SGTCid condition conc unit YFH7|YFR007W.score YFH7|YFR007W.strain.pval YFH7|YFR007W.strain.significant YFH7|YFR007W.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene SGTC_1294 1000-1494 117 µM 27.7545026028295 1.13011525767954e-190 yes 1 7.68774758954428e-170 1 712797 YDL207W GLE1 SGTC_64 000l-0018 272.079 µM 17.3465634104595 7.26193223423005e-76 yes 2 1.04701268795324e-67 15 6811119 SGTC_103 0844-0104 51.839 µM 16.6472834573181 4.81529493960293e-70 yes 3 1.58326715061157e-62 7 5375804 SGTC_58 0957-0393 9 µM 14.1987007828751 1.5559894071727e-51 yes 4 4.6663311048722e-46 32 6997992 SGTC_158 k038-0087 26.446 µM 14.1222170538933 5.28688602144505e-51 yes 5 1.38566669987036e-45 14 X158 SGTC_3059 1327-0034 3 µM 14.0147245584658 2.91707687547806e-50 yes 6 6.33444247642295e-45 7 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_86 0417-1630 471.922 µM 14.0127957190909 3.00750570414231e-50 yes 7 6.50888630451722e-45 20 3634867 SGTC_142 0335-0849 62.6745 µM 13.0283587006873 1.02126906124089e-43 yes 8 4.22018674585563e-39 21 3889043 YPR107C YTH1 SGTC_137 0438-0332 85.389 µM 12.9709841631722 2.37274933269602e-43 yes 9 8.93603794091696e-39 19 2063393 YER012W | YPR107C PRE1 | YTH1 SGTC_2582 agaric acid 100 µM 10.6566332907616 6.47228529497079e-30 yes 10 8.11845760156934e-27 54 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase. SGTC_794 k038-0031 316 µM 10.2261481939016 1.05607693946996e-27 yes 11 7.57113709715816e-25 15 6624242 SGTC_3063 1327-0034 4 µM 8.80246390752237 5.03958228029324e-21 yes 12 6.69223056798846e-19 13 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_67 0335-0847 266 µM 8.23307619976775 1.25675066357641e-18 yes 13 9.1233022701859e-17 36 4552207 YOR254C SEC63 SGTC_852 0418-0143 439 µM 7.60878621725341 3.52795935365109e-16 yes 14 1.38340982079065e-14 13 5369229 SGTC_3060 1327-0027 12.5 µM 7.58589038323733 4.3027414726336e-16 yes 15 1.6510575501481e-14 15 16000455 YPR107C YTH1 SGTC_340 k038-0059 454 µM 7.32019494078454 4.12913618414469e-15 yes 16 1.23805494383586e-13 9 23733424 SGTC_36 0335-0881 14.2 µM 6.90323640193212 1.22653150038189e-13 yes 17 2.54154667889231e-12 48 23828853 SGTC_107 0358-0022 2.6945 µM 6.89192852350837 1.34109151988438e-13 yes 18 2.75205148716995e-12 10 521106 YGL093W | YPR107C SPC105 | YTH1 SGTC_3064 1327-0027 10 µM 6.42186982769404 4.84429803532163e-12 yes 19 6.73052560258818e-11 6 16000455 YPR107C YTH1 SGTC_1759 st043059 70 µM 5.89313954335212 2.04650004416163e-10 yes 20 1.8946307433719e-09 3 669426 SGTC_294 k038-0071 157 µM 5.66785808953591 9.18663100964745e-10 yes 21 7.22968210326197e-09 19 24152826 SGTC_384 k007-0144 5.16 µM 5.62927227706401 1.18148217250787e-09 yes 22 9.04857640562393e-09 29 6824886 SGTC_791 1348-1292 225 µM 5.46538490520819 3.37781959018329e-09 yes 23 2.30951708004019e-08 11 5437054 SGTC_1161 k007-0610 110 µM 5.39353519705312 5.30410465523605e-09 yes 24 3.45423927831553e-08 70 5843850 SGTC_1644 st010134 20.9 µM 5.35985481655893 6.54082815983822e-09 yes 25 4.16444295427162e-08 2 3818134 SGTC_1652 st011932 78 µM 4.99956981220714 5.69627645767527e-08 yes 26 2.8729182877601e-07 4 1551076 SGTC_893 0958-0369 48.9 µM 4.95867382070968 7.21763880175148e-08 yes 27 3.54880089928019e-07 12 6819948 SGTC_846 0335-0850 148 µM 4.9280109306347 8.60906007378713e-08 yes 28 4.15354854549752e-07 19 6819598 SGTC_1106 tegaserod maleate 11.7 µM 4.88532317558286 1.09849842166712e-07 yes 29 5.16296705363869e-07 4 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation. SGTC_2420 aureobasidin a 50 nM 4.84293037104508 1.39655620965206e-07 yes 30 6.39690656568628e-07 21 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1 SGTC_90 0870-0863 4.608 µM 4.76463801110776 2.16457630242808e-07 yes 31 9.45964939445797e-07 29 1738164 SGTC_1426 4048-4480 71.7 µM 4.72398855669802 2.71045212772275e-07 yes 32 1.15631717734651e-06 7 14224343 SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM 4.5442502372744 7.17052043214313e-07 yes 33 2.75655665935572e-06 26 6728940 SGTC_2651 TUB2.036 5 µM 4.47540076212456 1.03123907014871e-06 yes 34 3.81340588114237e-06 137 15992207 YFL037W TUB2 SGTC_544 k015-0020 52.4 µM 4.32174619714797 2.27772985944016e-06 yes 35 7.73995971257858e-06 7 3008304 SGTC_778 3456-2434 196 µM 4.28819549078191 2.6987951699461e-06 yes 36 9.00652636987542e-06 65 5539063 SGTC_1634 st006576 41 µM 4.23252129775142 3.56654854785088e-06 yes 37 1.15543011059675e-05 16 3915356 SGTC_2295 7971645 200 µM 4.14122249859409 5.59311631320045e-06 yes 38 1.72729823118848e-05 18 2978226 YKL099C UTP11 SGTC_911 3456-4043 236 µM 3.97853960258801 1.21945506533247e-05 yes 39 3.46699314607364e-05 27 914281 SGTC_2307 7538926 6.34 µM 3.97607889163342 1.23364737361177e-05 yes 40 3.5030445771913e-05 43 96582 SGTC_842 0271-0008 11.1 µM 3.8992620009184 1.7645887005672e-05 yes 41 4.82431627449417e-05 21 1221709 SGTC_1635 st007035 42.4 µM 3.82463026358419 2.48334383967069e-05 yes 42 6.54842428080674e-05 221 3716403 SGTC_216 k038-0035 28.382 µM 3.77778171020852 3.06804421424758e-05 yes 43 7.91157371442974e-05 53 4444231 YPR107C YTH1 SGTC_865 0488-0499 301 µM 3.69728167642423 4.38792047932972e-05 yes 44 0.000108960248605582 22 9634651 SGTC_2429 5902844 64.44 µM 3.68928858603493 4.54489800101787e-05 yes 45 0.000112441007460277 33 1927790 YGL093W | YPR107C SPC105 | YTH1 SGTC_2370 9071495 200 µM 3.54401535866345 8.50750233342884e-05 yes 46 0.00019704114393874 34 21791103 SGTC_200 k038-0079 37.545 µM 3.52166804724161 9.35013915809554e-05 yes 47 0.000214420384096806 65 3436683 SGTC_352 k048-0007 5.11 µM 3.4056288804369 0.000151384121293371 yes 48 0.000330059237411818 105 6811911 SGTC_2430 5571206 200 µM 3.37953365966663 0.000168377069170517 yes 49 0.00036304457867265 81 1731771 SGTC_3278 9139605 49.47 µM 3.34335888038178 0.000194900153409431 yes 50 0.000413853902569725 33 7958859 SGTC_1763 st044482 94.5 µM 3.33031132483994 0.000205389344899464 yes 51 0.000433744660159765 34 88505 SGTC_114 0364-0001 490.298 µM 3.26308285864803 0.00026831010677158 yes 52 0.00055103646585222 88 4003655 SGTC_2533 agelasine 13.65 µM 3.25322196414552 0.000278923653591073 yes 53 0.000570521642802165 83 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase. SGTC_618 k072-0232 33.2 µM 3.24512012392502 0.000287935143805139 yes 54 0.000587005439351233 28 5872756 YGL099W LSG1 SGTC_871 0574-0004 149 µM 3.22920084614849 0.000306436629050327 yes 55 0.000620683400344791 77 9551173 SGTC_1445 4239-0156 97.7 µM 3.16100306497204 0.00039892151800264 yes 56 0.000786134220266273 66 4008346 SGTC_2915 7971052 15.16 µM 3.15464453384664 0.000408750810338044 yes 57 0.00080346880600339 18 5741558 SGTC_977 1348-1378 135 µM 3.10672017933214 0.00049038520738148 yes 58 0.00094587686117217 55 X977 SGTC_2433 5607874 27.82 µM 3.07783978500768 0.000546618251636634 yes 59 0.00104253491215019 61 2252428 SGTC_936 3005-4620 401 µM 3.07320622879484 0.00055617670655601 yes 60 0.00105886040857635 67 777207 SGTC_1912 st060209 90.8 µM 3.0699948957544 0.000562891709394049 yes 61 0.001070312146376 76 688787 SGTC_764 1951-2361 146 µM 3.03645653695895 0.000637641289030995 yes 62 0.00119688308336106 79 5438930 SGTC_2384 9036245 200 µM 2.9796073158982 0.000785583368636192 yes 63 0.00144309056074201 77 6462766 SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM 2.9577285171941 0.000850498156683958 yes 64 0.00154957469931449 46 689007 SGTC_628 1636-0253 16 µM 2.92381419777414 0.000960929012216098 yes 65 0.00172885535123669 93 4456143 SGTC_1338 1486-1223 76 µM 2.9087956241408 0.00101391687841618 no 66 0.00181411981686869 66 3444526 SGTC_2375 9072683 200 µM 2.89354769667237 0.00107044504959496 no 67 0.00190458216147222 72 16798029 SGTC_3232 9132874 49.47 µM 2.88461633336425 0.00110488364909358 no 68 0.00195945468652326 57 3784940 SGTC_2845 9003024 42.97 µM 2.88008586647019 0.00112273824777628 no 69 0.00198783438551511 106 2990173 SGTC_3198 9112019 49.47 µM 2.87502752129247 0.00114298532383396 no 70 0.00201996141237173 63 45595555 SGTC_2451 5856223 45.7 µM 2.86971643673196 0.00116460354298548 no 71 0.00205420026145852 68 2179896 SGTC_938 3126-1755 342 µM 2.85070526442648 0.00124509154631434 no 72 0.00218111920555608 52 1777771 SGTC_2997 9067075 71.4286 µM 2.8369559061332 0.00130643943635009 no 73 0.00227729507852242 120 27209819 SGTC_1766 st045414 44.774 µM 2.82353900298092 0.00136895597865143 no 74 0.00237483232694391 103 253960 SGTC_1672 st016598 6.51 µM 2.8045549409934 0.0014620877366014 no 75 0.00251930498071454 138 4665860 YNL267W PIK1 SGTC_931 2812-0076 566 µM 2.80319842895819 0.00146895892667348 no 76 0.00252992639060374 95 3450959 SGTC_941 3237-0776 460 µM 2.79973345392615 0.00148664417102332 no 77 0.00255724095045566 73 760008 SGTC_518 1021-0119 62.6 µM 2.76227010158659 0.0016906501580071 no 78 0.00287004852482681 116 1097762 SGTC_163 TUB2.036 7.546 µM 2.75979909166561 0.00170496294250764 no 79 0.00289184589549369 225 15992207 YJR013W GPI14 SGTC_2369 9071472 200 µM 2.751375127631 0.0017545898648411 no 80 0.0029672820442474 72 17296037 SGTC_2421 5690543 90.72 µM 2.75112395945711 0.00175608951399742 no 81 0.00296955822103719 83 3397993 SGTC_2298 7976326 193.81 µM 2.74545010210667 0.00179027867273881 no 82 0.00302139779994882 46 2235818 SGTC_1051 3253-3903 78 µM 2.72286992174956 0.00193242304030047 no 83 0.00323587670087999 102 5509239 SGTC_184 1494-0393 24.714 µM 2.7075359951061 0.00203471691035611 no 84 0.00338923598376853 155 3090647 SGTC_2252 omeprazole 400 µM 2.67827799458689 0.00224364024692673 no 85 0.00370008854787265 46 4594 A proton pump inhibitor. SGTC_1237 0330-0133 46.1 µM 2.63495077457756 0.00258884150227763 no 86 0.0042074742921255 89 X1237 YHR072W ERG7 SGTC_451 chloral hydrate 100 µM 2.6319424657649 0.00261450467762104 no 87 0.00424491192771847 173 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1 SGTC_165 k038-0023 64.381 µM 2.631497321436 0.0026183215584288 no 88 0.00425047686258599 182 46368543 SGTC_1416 3966-0321 25.3 µM 2.62142629557405 0.00270603166718535 no 89 0.0043781346861487 107 582530 YLR208W SEC13 SGTC_2035 5154463 94.595 µM 2.61049917382291 0.00280419068383225 no 90 0.0045205095170715 106 2769623 SGTC_3207 9114163 49.47 µM 2.60854522752613 0.00282207791110594 no 91 0.00454639974717769 129 849233 SGTC_2111 5486399 200 µM 2.60607609985361 0.00284482850576682 no 92 0.00457930553912722 153 689674 SGTC_116 0155-0182 31.788 µM 2.58948737888358 0.00300201493831126 no 93 0.00480594731210398 221 771486 SGTC_1234 0326-0494 15.5 µM 2.55869112324448 0.00331471115516726 no 94 0.00525335239995635 86 1547813 SGTC_3342 9147791 14.508 µM 2.54474368462743 0.00346573109424286 no 95 0.00546789888774399 86 1838168 SGTC_1698 5-fluorocytosine 1.055 µM 2.53365013300728 0.00359023212299888 no 96 0.00564406867188952 77 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_2640 pentamidine 10.38 µM 2.51120435839053 0.00385448585962935 no 97 0.00601600106255284 140 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_1897 st060201 15 µM 2.49890733850012 0.00400653287822017 no 98 0.00622884400389835 107 611878 SGTC_188 3229-0966 278.469 µM 2.49566378485794 0.00404752286003272 no 99 0.00628608503595295 133 5722370 SGTC_1433 4060-0023 7.6 µM 2.4598369698063 0.00452589007914322 no 100 0.00695000707903476 104 3840627 SGTC_1575 cyproterone acetate 48 µM 2.45394099828569 0.00460927893202197 no 101 0.00706500817116952 128 9880 An androgen receptor antagonist and liver toxin. SGTC_2496 diffractaic acid 79.83 µM 2.45183130167369 0.00463944859181384 no 102 0.00710656395008797 139 94870 An apoptosis inducer which activates caspases. SGTC_1514 1189-1591 158 µM 2.43991171416411 0.00481323780530283 no 103 0.00734542585454405 165 767698 YMR146C TIF34 SGTC_138 0850-0259 40.9225 µM 2.43712479902558 0.0048546992320825 no 104 0.00740228448397448 349 6813004 SGTC_16 erodoxin 22.806 µM 2.43258018508956 0.00492299337353167 no 105 0.00749583582986477 195 3967339 Erodoxin inhibits Ero1. YML130C ERO1 SGTC_373 0844-0104 25.9 µM 2.40409327377838 0.0053709170027997 no 106 0.00810631802571543 176 5375804 SGTC_283 0987-0079 11.7 µM 2.39775470372648 0.00547538032813065 no 107 0.00824795395981688 154 411556 SGTC_1329 1447-1697 50.6 µM 2.39314350786654 0.00555250609517278 no 108 0.00835235294588242 128 2840515 SGTC_2467 5474540 200 µM 2.38699991970216 0.0056567610835651 no 109 0.00849324749350028 138 5413519 SGTC_29 0299-0004 12.984 µM 2.38655484767488 0.00566438091762546 no 110 0.00850353514707352 91 16871 A napthoquinone isolated from Swertia calycina. SGTC_2717 st081029 62.2815 µM 2.38526583095943 0.00568650090722187 no 111 0.00853339194913589 99 5292846 SGTC_2350 9023895 38.85 µM 2.37787771090568 0.00581476924640656 no 112 0.0087062997713955 142 2997209 SGTC_386 1509-0011 3.07 µM 2.37003696429175 0.00595369743238921 no 113 0.00889315347202163 284 3107280 SGTC_2445 5742597 35.57 µM 2.35738392596876 0.00618410611032239 no 114 0.00920210400632443 141 1774255 SGTC_2936 9038235 15.59 µM 2.34606097026093 0.00639695478285676 no 115 0.0094865017758998 150 4749415 SGTC_285 1486-1325 46 µM 2.32694636567408 0.00677100743253332 no 116 0.00998406001602798 128 22310230 SGTC_2269 7935389 174.42 µM 2.30052196535796 0.00731988419056226 no 117 0.0107093331616873 142 97605 SGTC_2313 7726885 200 µM 2.29425747068161 0.00745562224805582 no 118 0.0108878569588256 170 726423 SGTC_1317 1273-0028 910 nM 2.29337980977643 0.00747481530791922 no 119 0.010913073998226 160 5917803 YLR359W | YHR072W ADE13 | ERG7 SGTC_318 1488-0629 67.2 µM 2.26765533874178 0.00805704519419839 no 120 0.0116751109759406 123 3662576 SGTC_994 3910-0338 138 µM 2.25218446291125 0.0084260824568927 no 121 0.01215530872889 183 3479481 SGTC_1219 1469-0211 33.1 µM 2.25158454072823 0.00844068689471654 no 122 0.0121742694508642 116 6822282 SGTC_2933 9026794 32.47 µM 2.25075750920068 0.00846085648083928 no 123 0.0122004500568731 177 17586027 SGTC_504 lovastatin 124 µM 2.24757314294689 0.00853891210017873 no 124 0.0123017108621874 112 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1 SGTC_2791 5663188 71.43 µM 2.24503393883441 0.00860160547557738 no 125 0.0123829769433942 160 54690634 SGTC_2443 5493264 126.67 µM 2.23539579575997 0.00884326268594964 no 126 0.0126956879420089 147 5340055 SGTC_3031 9088762 49.47 µM 2.22746507762696 0.0090465514019412 no 127 0.012958103636814 166 205253 SGTC_2329 6138490 200 µM 2.22539465522386 0.00910029177431834 no 128 0.0130273780156044 161 720019 SGTC_2331 7980721 200 µM 2.22505108006821 0.00910923668213375 no 129 0.0130389046335222 173 2981221 SGTC_2926 9010726 65.15 µM 2.22186573716473 0.00919253362738283 no 130 0.0131461902628559 178 2994293 SGTC_450 aminopyrene 156 nM 2.21629441651028 0.00933982771624995 no 131 0.0133356725890325 192 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1 SGTC_2608 thymoquinone 42.66 µM 2.20631412243682 0.00960885340375315 no 132 0.0136810066218453 150 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC). SGTC_7 0192-1582 4.227 µM 2.20441842326443 0.00966071176413916 no 133 0.0137474655976753 251 252616 SGTC_3183 9108214 49.47 µM 2.17462594597903 0.0105084237721062 no 134 0.014829079189485 57 4974831 SGTC_3217 9129673 49.47 µM 2.17415710261203 0.0105222665380156 no 135 0.0148466693729868 207 17248312 SGTC_2424 5537928 59.2 µM 2.16424306912325 0.0108187248103921 no 136 0.0152228497264598 217 5382802 SGTC_127 0180-0333 59.125 µM 2.15814442474174 0.011004681676727 no 137 0.0154583023554615 250 771601 SGTC_1436 4092-1007 8.32 µM 2.15356656512879 0.0111460886076491 no 138 0.0156370893332469 161 2881121 SGTC_1662 st014054 52 µM 2.14758492822024 0.0113332364705333 no 139 0.0158733718963064 121 2838777 SGTC_2639 lactacystin 53 µM 2.12734632314085 0.0119868370998316 no 140 0.0166956592586306 200 3870 A proteasome inhibitor. SGTC_305 1682-2595 20.8 µM 2.11973939740814 0.0122408211477354 no 141 0.0170140142803067 187 226033 SGTC_2041 5107442 45.335 µM 2.11814347813854 0.0122946944212849 no 142 0.0170814591569936 223 793005 SGTC_2396 5342950 42.78 µM 2.11494274828946 0.0124033605194397 no 143 0.0172174135817841 246 1886677 SGTC_1646 st011709 75.6 µM 2.08937675783566 0.0133015868946252 no 144 0.0183369108690452 147 5757843 SGTC_2701 st077767 14.721 µM 2.0795137528035 0.0136628372014935 no 145 0.0187850775345802 246 5721188 SGTC_3235 9132602 49.47 µM 2.0633951057172 0.0142714367576597 no 146 0.0195375522914495 214 4912240 SGTC_2466 5983409 37.09 µM 2.06072475924328 0.0143744846815061 no 147 0.0196646530770269 184 2879657 SGTC_2885 9057732 51.95 µM 2.05147267661213 0.0147364904751042 no 148 0.020110468922383 205 6471414 SGTC_3331 9141060 1.957 µM 2.04966712691706 0.0148080433265138 no 149 0.0201984624978463 193 4906567 YPR165W RHO1 SGTC_2862 9027634 71.43 µM 2.04619973529935 0.0149462921094123 no 150 0.0203683616932247 205 5012562 SGTC_1033 k072-0102 21.3 µM 2.04389649674527 0.0150387368919534 no 151 0.020481886656135 236 5965931 SGTC_839 0122-0028 230 µM 2.04191642255438 0.0151186032830135 no 152 0.0205799112276423 276 759448 SGTC_639 0833-0042 114 µM 2.03976060296638 0.0152059725179894 no 153 0.0206870877708793 242 5978911 YPR085C | YHR062C ASA1 | RPP1 SGTC_1315 1237-0019 3.69 µM 2.0270215123672 0.0157311550762043 no 154 0.0213301063453868 187 825140 SGTC_861 0443-0273 110 µM 2.02431090437674 0.0158448886309465 no 155 0.0214690861820202 190 6149169 SGTC_1671 st016596 74.5 µM 2.02392265676241 0.0158612365843179 no 156 0.0214890551692765 215 2829167 SGTC_1082 camptothecin 424.86 nM 2.00998405704558 0.016457806250068 no 157 0.0222164381317853 233 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_1966 st070145 16.1 µM 2.00494033010347 0.0166783599766825 no 158 0.0224847132486687 207 3748532 SGTC_1898 st060199 18.6 µM 1.9950709108681 0.0171172554666494 no 159 0.0230175732301661 187 688866 SGTC_1654 st012436 41.8 µM 1.99252360860108 0.0172321242740693 no 160 0.0231568187435425 180 4323132 SGTC_117 lucigenin 22.078 µM 1.98973703533121 0.0173585364799962 no 161 0.0233099553457108 315 65100 An acridine derivative; a dye stuff and potential carcinogen. SGTC_715 0868-0130 184 µM 1.97641449710486 0.0179739103828012 no 162 0.0240539254788476 186 2876258 SGTC_1374 2889-5571 141 µM 1.97613933215784 0.0179868139709739 no 163 0.0240694993873096 268 2853281 SGTC_2852 9023854 51.95 µM 1.97275324196647 0.0181462490594566 no 164 0.0242618413762763 218 19798528 SGTC_828 2074-0507 139 µM 1.96974880589858 0.0182887208362232 no 165 0.0244335832159691 248 X828 SGTC_3271 9137798 49.47 µM 1.95667487037357 0.0189198409283439 no 166 0.0251928531101697 160 6498326 SGTC_1233 0325-0408 14.2 µM 1.95456758347174 0.0190232804716186 no 167 0.0253170653070681 234 12874 SGTC_3240 9133527 49.47 µM 1.95347018083151 0.0190773384099185 no 168 0.025381953659804 202 17617455 SGTC_1718 roemerine 11.9335 µM 1.94245477085256 0.0196272295093224 no 169 0.0260410351408609 301 235224 An aporphine alkaloid with mutagenic activity. SGTC_1283 0922-0125 16.4 µM 1.94139748401751 0.0196807103767698 no 170 0.0261050416235237 241 3360884 SGTC_2524 avocatin b 10.57 µM 1.93725180759793 0.0198916068524379 no 171 0.0263572850619164 194 6710748 SGTC_1977 st070720 65.3 µM 1.93167249774435 0.0201784589530103 no 172 0.0266999706859737 199 682188 SGTC_732 3970-1727 52.7 µM 1.93127472068676 0.0201990433628162 no 173 0.0267245439254526 193 1275699 SGTC_2570 licareol 100 µM 1.92239545805102 0.0206631885764544 no 174 0.0272780083316463 259 443158 SGTC_81 0411-0046 9.971 µM 1.92204561055713 0.0206816595939945 no 175 0.027300009441876 213 12925265 SGTC_942 3253-1115 227 µM 1.90911996819256 0.0213739680919867 no 176 0.0281233086855109 255 46497897 SGTC_1910 st062352 60.4 µM 1.89857495272133 0.021953188356937 no 177 0.028810192124356 292 2245730 SGTC_1678 st019265 80.2 µM 1.89400691559689 0.0222081867535621 no 178 0.0291120459709974 285 5367020 SGTC_3050 9093513 49.47 µM 1.89235677011475 0.02230091412187 no 179 0.0292217308753024 229 25236664 SGTC_1028 k015-0029 4.8 µM 1.89057412704441 0.0224014537957326 no 180 0.0293406083632137 303 4588309 SGTC_2828 7998861 71.43 µM 1.8889638121742 0.0224926026810523 no 181 0.0294483389319073 204 2988188 SGTC_562 3772-2733 112 µM 1.88699002179586 0.0226047518258223 no 182 0.0295808338759567 328 2876874 YIL048W NEO1 SGTC_859 0439-0102 54.6 µM 1.87536631441141 0.0232748052906851 no 183 0.0303711730129878 263 610143 SGTC_3248 9135562 49.47 µM 1.87020800806162 0.0235774705673025 no 184 0.030727469049583 250 17650701 SGTC_1422 4031-0024 15.5 µM 1.8666404264632 0.0237887305322589 no 185 0.0309759090779323 248 782427 SGTC_1871 st057448 67.3 µM 1.86303624928837 0.0240037712640825 no 186 0.0312285831922519 281 691747 SGTC_533 1222-0222 6.71 µM 1.8620385423928 0.0240635866125923 no 187 0.0312988288387765 279 3982874 SGTC_551 k048-0028 34.9 µM 1.85253419956575 0.0246397028777819 no 188 0.031974575650658 279 6836383 SGTC_1614 st002383 48.6 µM 1.84674571942763 0.0249962161307063 no 189 0.032392001071441 257 1947235 SGTC_251 melphalan 456.522 µM 1.84251457211125 0.0252595404610272 no 190 0.0326999584955935 318 460612 A DNA alkylator. SGTC_388 3',4'-dichloroisocoumarin 16.7 µM 1.84146137091277 0.0253254462423835 no 191 0.0327769882138948 239 1609 A potent and irreversible inhibitor of serine proteases. SGTC_1097 itavastatin 7.23 µM 1.84145711835449 0.025325712644881 no 192 0.0327772995432654 290 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49 SGTC_2691 st077356 60.2 µM 1.83272953422032 0.0258774228236196 no 193 0.0334214014401136 289 2839272 SGTC_2450 5739737 12.93 µM 1.82804174886261 0.0261778872632555 no 194 0.0337716430972473 258 2262825 SGTC_885 0865-0106 16.8 µM 1.82518573519523 0.0263623699583114 no 195 0.0339865028470045 296 2793380 SGTC_2774 tamoxifen 10.92 µM 1.82249533568472 0.026537147622747 no 196 0.0341899304124068 264 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  SGTC_1750 st081859 2.357 µM 1.80353519370362 0.0277965105848082 no 197 0.0356521017267493 510 5291695 SGTC_2902 5787006 60.46 µM 1.79885377334316 0.0281150099694731 no 198 0.0360209072880943 293 591003 SGTC_3270 9137563 49.47 µM 1.79743529263518 0.0282121137155634 no 199 0.0361332710437784 241 17015724 SGTC_1414 3917-0015 5.4 µM 1.79103187403748 0.0286539484604697 no 200 0.0366440901179551 231 6618702 SGTC_2748 diazoxide 86.69 µM 1.78808931520544 0.0288589060089901 no 201 0.0368807995901253 211 3019 A potassium channel activatior. SGTC_3347 9188721 44.724 µM 1.76483870215298 0.030521605495706 no 202 0.0387954390557612 253 44118411 YKL104C | YBL026W GFA1 | LSM2 SGTC_884 0851-0618 334 µM 1.76271544022685 0.0306773207517943 no 203 0.038974247647614 317 9642473 SGTC_1679 SEC14.276 6.7 µM 1.76071527466886 0.0308246095705745 no 204 0.0391433030612028 353 1005053 YMR079W SEC14 SGTC_3009 9080819 71.4286 µM 1.75418501135021 0.0313095680782815 no 205 0.0396994053340399 279 17027216 SGTC_490 phenamil 164 µM 1.75168940731954 0.0314965584321032 no 206 0.0399136146502465 186 4755 Irreversibly blocks amiloride-sensitive Na+ channels. SGTC_2681 menadione 3.18 µM 1.74877383347372 0.0317161845258217 no 207 0.0401650607808393 308 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_3233 9132340 49.47 µM 1.74508425143666 0.0319959278986682 no 208 0.0404851022416432 291 17682950 SGTC_2469 5655019 90.81 µM 1.74488014748771 0.0320114623068189 no 209 0.0405028668724973 316 2788239 SGTC_1232 0279-0259 161 µM 1.7409128207155 0.032314655778658 no 210 0.0408494305293969 318 1560000 SGTC_2220 6782180 200 µM 1.73057494868217 0.0331158502886677 no 211 0.0417638014775392 196 833803 SGTC_408 cantharidin 100 µM 1.72983102665664 0.0331741306537333 no 212 0.0418302346520895 356 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_663 1486-0733 13.9 µM 1.71032834265158 0.0347324021104016 no 213 0.0436025867685291 392 722445 YPR165W RHO1 SGTC_1510 1123-0200 71.5 µM 1.71020330049006 0.0347425836704342 no 214 0.0436141428039814 390 5378812 YNL149C | YNL150W PGA2 | YNL150W SGTC_2178 5812956 200 µM 1.70586278252455 0.0350975323047613 no 215 0.0440168152745417 291 5403383 SGTC_3353 9151644 39.2805 µM 1.70546037219756 0.0351305898507036 no 216 0.0440542984828172 308 4909158 SGTC_1632 st005650 90 µM 1.70434380062075 0.0352224487297356 no 217 0.0441584382780172 319 2759605 SGTC_2848 9016370 25.97 µM 1.70147263380662 0.0354595609056978 no 218 0.0444271361787282 362 7894410 SGTC_1802 st050112 57.9 µM 1.69857602824262 0.0357000985873827 no 219 0.0446995481715345 307 4662563 SGTC_572 0960-0087 17.7 µM 1.6941916549121 0.0360667248060848 no 220 0.0451144350430357 391 6796365 SGTC_3091 9116372 49.47 µM 1.6850762733489 0.0368388349173322 no 221 0.0459869283381309 312 17169793 SGTC_1845 st056753 3.01 µM 1.67434600068179 0.0377649975513843 no 222 0.0470313093961862 363 5375839 SGTC_87 0100-0052 35.5 µM 1.67170704761841 0.0379956619523973 no 223 0.0472910518724197 581 200187 YGR083C | YDR527W GCD2 | RBA50 SGTC_54 0159-0055 9 µM 1.66098216247851 0.0389449531004622 no 224 0.0483585146167758 337 3319099 SGTC_1418 3966-3099 2.4 µM 1.66010955960385 0.0390230319188833 no 225 0.0484462070661224 363 740335 SGTC_717 1532-0246 73.2 µM 1.65930246421377 0.0390953626652392 no 226 0.0485274294892591 359 9561992 SGTC_3246 9135460 32.98 µM 1.65640360427182 0.0393560548517124 no 227 0.0488200558431905 255 41446951 SGTC_1694 st024011 44.9 µM 1.65401046570762 0.039572332156489 no 228 0.0490626931364167 374 2787533 SGTC_14 0354-0009 295 µM 1.65225172875636 0.0397318915404981 no 229 0.049241622599445 353 1713507 SGTC_2620 irigenin 100 µM 1.64114334051949 0.040751811160741 no 230 0.0503838319362671 383 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro. SGTC_377 3970-0964 33.1 µM 1.63034520770058 0.0417635071920092 no 231 0.0515142789868952 459 16481235 SGTC_875 0709-0210 25.7 µM 1.62827673225571 0.0419596086077054 no 232 0.0517331104280077 400 6251364 SGTC_234 nsc-17383 10.7 µM 1.62023477553888 0.0427291185674968 no 233 0.0525909269300536 412 408974 SGTC_2362 9071156 126 µM 1.61645903040893 0.0430943228429336 no 234 0.0529975522237065 363 653133 SGTC_3027 9089541 49.47 µM 1.61529476971066 0.0432074417770763 no 235 0.0531234378857051 387 9943819 SGTC_1133 3473-0247 50 µM 1.60974089056155 0.0437503582560859 no 236 0.0537272170780814 411 711311 SGTC_2160 5660466 132.927 µM 1.60553908598346 0.0441647497491721 no 237 0.0541876093264176 356 2859134 SGTC_2084 5306078 60.6385 µM 1.60460439879075 0.0442573596001453 no 238 0.0542904463865446 369 679340 SGTC_1179 1021-1431 9.29 µM 1.59936930156151 0.0447789560661954 no 239 0.0548692846017386 460 2840958 SGTC_1076 itraconazole 331 nM 1.59660832047487 0.0450560323486522 no 240 0.0551765215295905 369 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1 SGTC_2085 5307070 144.047 µM 1.58726460728568 0.0460039639638846 no 241 0.0562263637917836 326 2840351 SGTC_89 0302-0250 142.109 µM 1.58516612169071 0.0462190460598177 no 242 0.0564642978031378 401 4203518 YLR208W SEC13 SGTC_788 1182-0090 188 µM 1.58350579837349 0.046389790755775 no 243 0.0566531130590228 503 5715185 SGTC_3076 9116187 49.47 µM 1.58268334124167 0.046474558134627 no 244 0.0567468285651669 343 27241210 SGTC_3029 9088683 49.47 µM 1.58183969629591 0.0465616383847036 no 245 0.0568430851591942 352 25236615 SGTC_864 0469-0573 172 µM 1.57946453638781 0.0468075036160704 no 246 0.0571147723325587 361 689425 SGTC_1145 3546-0597 10.2 µM 1.57382991141917 0.0473949397613756 no 247 0.057763388466348 415 875334 SGTC_1567 st069303 68.4 µM 1.57181696418933 0.0476062256019512 no 248 0.0579965030581491 416 5581319 SGTC_1521 st012942 49.4 µM 1.56868938210566 0.0479360033765499 no 249 0.0583601669394648 421 24207259 SGTC_1192 1488-0095 21.4 µM 1.55610940053505 0.0492809689808177 no 250 0.0598410400102346 375 915875 SGTC_699 0375-0592 111 µM 1.55275145503649 0.0496450266675981 no 251 0.0602412621578361 362 762578 SGTC_1500 4488-1866 171 µM 1.55149017681091 0.04978232357381 no 252 0.0603921298130637 433 2900003 SGTC_1565 sinapyl alcohol 95.1 µM 1.54915105575812 0.0500377511166547 no 253 0.060672706000051 382 5280507 A phenol propionate derived from cinnamic acid. SGTC_268 camptothecin 39.6153 µM 1.54886802145654 0.0500687286668567 no 254 0.0607067248334042 516 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_3086 9117350 49.47 µM 1.54485968065436 0.0505090774112387 no 255 0.0611901039092641 276 2679265 SGTC_2172 5754775 163.918 µM 1.54383519736029 0.0506221188587472 no 256 0.0613141310827123 391 2263357 SGTC_753 1322-0200 289 µM 1.54222219133089 0.0508005061822649 no 257 0.0615098046224232 392 5403907 SGTC_1247 0448-0043 5.84 µM 1.53580964027653 0.0515146454871505 no 258 0.0622925373301296 462 3089013 YGL099W LSG1 SGTC_401 neomycin 50 µM 1.52764653991739 0.0524352600179191 no 259 0.0633001600122481 359 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis. SGTC_1176 0848-0131 83.3 µM 1.52629617868776 0.0525888018012391 no 260 0.0634680599536451 444 6769040 SGTC_2382 9035899 200 µM 1.52348307995324 0.0529098088784323 no 261 0.0638189453346242 415 6462679 SGTC_1279 0874-0590 65.2 µM 1.5208759518379 0.0532086981551457 no 262 0.064145484911214 411 3523074 SGTC_1884 5633444 25 µM 1.51669090865785 0.0536912816190133 no 263 0.0646723703636338 460 5724239 SGTC_1620 st003704 16.5 µM 1.51374563666817 0.0540329788045163 no 264 0.0650451827011751 390 2834414 SGTC_593 1203-0218 61.7 µM 1.51272206332735 0.0541521314258686 no 265 0.0651751364020792 394 3666956 SGTC_2600 tangeritin 87.95 µM 1.50989184838387 0.0544826750175393 no 266 0.0655355115179391 392 68077 A bioactive flavone. SGTC_2935 9038016 29.96 µM 1.50833725059388 0.0546649158661085 no 267 0.065734117002807 435 6463195 SGTC_937 3122-0005 46.7 µM 1.50503335457747 0.0550538221575597 no 268 0.0661577508041892 441 759535 SGTC_73 0327-0325 16.231 µM 1.49785658502026 0.0559061404530278 no 269 0.0670852577641299 476 53298 SGTC_1497 4476-2978 41.3 µM 1.49707610558294 0.0559994549243638 no 270 0.0671867281676229 464 1528379 SGTC_2130 NSC 7 2.4545 µM 1.49539257542657 0.0562011568257576 no 271 0.0674060085429383 449 21448 SGTC_190 3970-0790 3.722 µM 1.49379273634008 0.0563933621865517 no 272 0.0676149003246661 383 2832352 SGTC_335 4077-0256 27.6 µM 1.49349701175743 0.056428947336176 no 273 0.0676535679433609 484 3121989 SGTC_2094 5332512 191.667 µM 1.49303454663172 0.0564846321953568 no 274 0.0677140720526178 438 755774 SGTC_2676 harmalol 100 µM 1.48473704782875 0.0574911003108204 no 275 0.0688067468350286 433 5459187 A monoamine oxidase inhibitor SGTC_1533 dihydroergotamine mesylate 29.4 µM 1.48336066863598 0.0576594078880077 no 276 0.0689893056895503 446 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release. SGTC_1735 st034310 56.75 µM 1.4801796673718 0.0580498723584813 no 277 0.0694126525502441 443 871153 SGTC_3185 9108267 49.47 µM 1.47191090750565 0.0590745769131755 no 278 0.0705224688673245 452 4910486 SGTC_654 1124-0271 80.9 µM 1.47122699390943 0.0591599621128823 no 279 0.0706148696537311 476 5403748 SGTC_2201 6605497 169.863 µM 1.47003594144854 0.059308893581691 no 280 0.0707760099989671 399 670741 SGTC_2223 6903751 107.57 µM 1.46444439621781 0.0600120040547891 no 281 0.0715362826099877 366 5598863 SGTC_1251 0490-5699 265 µM 1.46399183878541 0.060069195347826 no 282 0.0715980891266351 499 3883818 SGTC_342 k048-0088 23.3 µM 1.45850909375443 0.0607654645566866 no 283 0.0723501352066734 443 6820570 SGTC_803 4488-1585 147 µM 1.45748398718084 0.0608963433141368 no 284 0.0724914141730192 399 747204 SGTC_1103 duloxetine 36.1 µM 1.45666353061451 0.0610012524326565 no 285 0.0726046407030322 501 60835 A selective serotonin reuptake inhibitor. SGTC_925 2064-1272 59.6 µM 1.45469319057171 0.0612537704607749 no 286 0.0728771092873217 428 6815817 SGTC_683 panaxydol 45 µM 1.44814665737248 0.0620986399797335 no 287 0.0737880196071863 465 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis. SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM 1.437797728388 0.063452743979226 no 288 0.0752457270483715 520 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_1060 3448-7350 82 µM 1.4368487164504 0.0635780588121532 no 289 0.0753804922290599 491 570178 SGTC_492 tmb-8 126 µM 1.4357487690682 0.0637235451888802 no 290 0.0755369212089619 288 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1 SGTC_449 xestospongin c 11.1929 µM 1.43554724145367 0.0637502286258992 no 291 0.0755656082442297 487 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1 SGTC_853 0419-0306 21 µM 1.43027772706357 0.06445103270313 no 292 0.0763186623529939 435 762713 SGTC_710 3448-4187 58 µM 1.42933267664113 0.0645773476091734 no 293 0.0764543191752862 566 3946412 SGTC_617 3770-0098 35 µM 1.42513225330748 0.0651411018580718 no 294 0.0770594874549245 448 5962639 SGTC_862 0452-0056 10.2 µM 1.42281560785611 0.065453657261452 no 295 0.0773948077941061 438 1575396 YLR359W | YHR072W ADE13 | ERG7 SGTC_2072 5231554 129 µM 1.42244069520078 0.0655043486064642 no 296 0.0774491781525463 459 789545 SGTC_2123 5259487 200 µM 1.42113402772093 0.0656812590301083 no 297 0.07763889964267 476 2173474 SGTC_2695 st077686 51.995 µM 1.41815577451906 0.0660858705027815 no 298 0.0780726452713295 441 2876092 SGTC_2066 5222451 176 µM 1.41805478879401 0.0660996237198173 no 299 0.0780873847474247 544 2281147 SGTC_987 1497-1013 404 µM 1.41705559170633 0.0662358236188565 no 300 0.0782333373886962 413 1676435 SGTC_1927 st060202 13.8 µM 1.40243410633113 0.068253819296044 no 301 0.0803928272973306 463 688887 SGTC_2004 4023728 41.89 µM 1.4019633834088 0.0683195662347605 no 302 0.0804630906568526 501 360084 YDR527W RBA50 SGTC_621 3584-0052 32.1 µM 1.39891277080803 0.0687468374864006 no 303 0.0809195712275854 497 2273927 SGTC_1126 isoteolin 1.0172 µM 1.39746607079291 0.0689501823619834 no 304 0.0811367313802275 480 133323 SGTC_2743 auranofin 4.32 µM 1.38766650325432 0.0703398147119279 no 305 0.0826193102471488 458 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold. SGTC_2592 piperlongumine 83.33 µM 1.38562937574765 0.0706313758972863 no 306 0.0829300517487163 454 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_2127 5253358 187.912 µM 1.38437731776255 0.0708110353673519 no 307 0.0831214752496881 434 20612 SGTC_2960 9079389 5.97 µM 1.38110324918645 0.0712824952708513 no 308 0.083623608353573 504 16457355 SGTC_2360 9040895 200 µM 1.37956654733832 0.0715046067790398 no 309 0.0838600716691153 456 4914414 SGTC_3338 9144300 39.5675 µM 1.37844925532771 0.0716664308751995 no 310 0.0840323124362013 511 4901274 SGTC_1619 st003326 88.7 µM 1.37714359195569 0.0718558937547462 no 311 0.0842339287712117 451 2849032 SGTC_984 1492-0255 2.91 µM 1.36585995067562 0.073509284220078 no 312 0.0859914625928543 465 1585198 SGTC_1773 st048542 73.5835 µM 1.36559024313727 0.0735491574659001 no 313 0.0860338053392914 517 3237138 SGTC_2977 9011197 71.43 µM 1.36041537142733 0.074317410984396 no 314 0.0868492584518272 430 2704722 SGTC_2219 9098279 200 µM 1.35657263547841 0.0748918511864705 no 315 0.0874585207553795 479 902349 SGTC_327 1273-0057 3.96 µM 1.3531318427472 0.0754090746860796 no 316 0.0880067572498069 482 3108138 SGTC_120 rhodamine 6G 52.259 µM 1.34866949601127 0.0760839086061223 no 317 0.0887215737899631 606 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase SGTC_2001 4023502 57.655 µM 1.34841841049629 0.0761220160654456 no 318 0.0887619229125835 538 108941 YCR052W RSC6 SGTC_2346 9031566 143.75 µM 1.34812519098503 0.0761665366253411 no 319 0.0888090602097285 488 4771086 SGTC_610 4215-0184 155 µM 1.34415405497898 0.0767714416989492 no 320 0.0894492876819107 547 5605015 SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM 1.34061564214054 0.0773135032724479 no 321 0.0900226379965318 559 66535 A nucleotide analog. SGTC_2764 methyldopa 94.69 µM 1.34021013872877 0.0773758089513499 no 322 0.0900885181609537 533 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent. SGTC_542 3381-0244 89.3 µM 1.34001217417665 0.0774062400944576 no 323 0.0901206935066364 591 1112843 SGTC_897 1000-0139 31.4 µM 1.33836895089648 0.0776591876181858 no 324 0.0903880975756022 509 6151020 SGTC_1483 3453-0561 55.9 µM 1.33422538850933 0.078299807524467 no 325 0.0910650006834427 574 4546991 SGTC_1891 st059073 26.2 µM 1.32926279050564 0.0790723198432397 no 326 0.0918806428800436 570 688754 SGTC_796 1234-0020 70.7 µM 1.32922500386856 0.0790782240347545 no 327 0.0918868741011723 536 46495034 SGTC_2980 9014342 25.29 µM 1.32734146925771 0.0793729510657428 no 328 0.0921978759336238 506 2996599 SGTC_399 oxolinic acid 75 µM 1.32616587422569 0.0795573238540752 no 329 0.0923923800966311 499 4628 A DNA gyrase inhibitor. SGTC_2819 7996655 46.38 µM 1.32471639094456 0.0797850974072223 no 330 0.0926326173159786 459 6456960 SGTC_2595 hexamethylquercetagetin 100 µM 1.3228127218046 0.0800849911316509 no 331 0.0929488327420103 515 386331 SGTC_1312 1218-2183 165 µM 1.32018539036264 0.0805002853153722 no 332 0.093386564261422 535 6744073 SGTC_3345 9148410 3.559 µM 1.31795761903816 0.0808536951090917 no 333 0.0937589177946855 477 4903596 SGTC_1172 0370-0043 85 µM 1.31619185996888 0.0811346432536656 no 334 0.0940548275632775 509 376585 SGTC_1360 1598-0022 39.8 µM 1.31464787388943 0.0813809084695138 no 335 0.0943141363402862 623 761525 SGTC_2368 9071271 200 µM 1.31032116350555 0.0820740207133257 no 336 0.0950436054555478 539 27209959 SGTC_160 3453-0671 289.699 µM 1.30938889851246 0.0822239444692836 no 337 0.0952013250114404 555 5322268 SGTC_2916 7875993 68.79 µM 1.30888478785699 0.082305099745739 no 338 0.0952866901356473 533 1299250 SGTC_52 0329-0193 875 nM 1.30348446127985 0.0831782700545125 no 339 0.0962047089598456 541 3739292 SGTC_1341 1486-1360 280 µM 1.30342985321979 0.0831871349815933 no 340 0.0962140250467315 554 3976547 SGTC_2663 amphotericin b 100 µM 1.3008243519905 0.0836109311631198 no 341 0.096659292230084 511 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_1804 st050076 49.1 µM 1.29320706568895 0.0848592190685134 no 342 0.0979697262818887 556 3895976 SGTC_1725 st036284 20.55 µM 1.29308586994365 0.0848791924153236 no 343 0.097990680805387 610 707914 SGTC_910 3454-3003 490 µM 1.28957578189613 0.0854591935773241 no 344 0.0985989944181245 590 820824 SGTC_1054 3429-0080 167 µM 1.28862016161812 0.0856176115920583 no 345 0.0987650853360867 580 1162877 SGTC_3329 9141233 27.5565 µM 1.28571257219537 0.0861009696708904 no 346 0.0992716959607905 526 4909101 YNL103W MET4 SGTC_545 4218-0007 221 µM 1.283693335575 0.0864378470853912 no 347 0.0996246385989856 540 2840508 SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM 1.28286348977086 0.0865765789888435 no 348 0.0997699529957249 593 6708561 SGTC_2659 sanguinarine 24.21 µM 1.2819026871106 0.0867374118236914 no 349 0.0999383926142247 556 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis. SGTC_43 0570-0105 72.5 µM 1.28051080799978 0.0869708002388671 no 350 0.100182773042903 658 1114046 YDL195W SEC31 SGTC_2996 9066192 71.4286 µM 1.28043435396494 0.0869836335265993 no 351 0.100196209156954 554 6472854 SGTC_3084 9116877 49.47 µM 1.27850306420731 0.0873082819354181 no 352 0.100536052516401 468 27241325 SGTC_2063 5246145 200 µM 1.27828576794004 0.0873448658207147 no 353 0.100574342067275 581 711240 SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM 1.27764074008098 0.0874535297731362 no 354 0.100688064416743 507 364106 SGTC_2989 9073649 71.4286 µM 1.27557643374718 0.08780196917127 no 355 0.101052644549283 656 21367202 SGTC_34 0469-0683 81.75 µM 1.27358692364923 0.0881387624588105 no 356 0.1014049244554 545 3690923 SGTC_3136 9095672 49.47 µM 1.27286891193499 0.088260546945323 no 357 0.101532281268476 493 17217380 SGTC_360 0957-0399 1.01 µM 1.27259046494728 0.0883078090506333 no 358 0.101581701937146 591 6752301 YPR165W RHO1 SGTC_2670 beta-carotene 100 µM 1.26761863900615 0.0891548780714431 no 359 0.102467086208823 469 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.) SGTC_1067 clotrimazole 1.36 µM 1.26675338278667 0.0893029107485215 no 360 0.102621742776023 607 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_1024 4507-0395 26 µM 1.26630294759851 0.0893800459563855 no 361 0.102702321035173 550 4201836 SGTC_632 0781-2353 4.65 µM 1.26098690294945 0.0902941442393438 no 362 0.103656782948113 606 6811515 YHR007C ERG11 SGTC_1270 0831-1170 17.3 µM 1.26056483921126 0.0903670148696532 no 363 0.103732836666662 627 6764716 SGTC_640 3381-0960 37.1 µM 1.2569456067786 0.0909936804189838 no 364 0.104386666207942 608 1745025 SGTC_996 3970-0799 1.8 µM 1.24981690340991 0.0922374243223455 no 365 0.105683219918674 758 6615648 YGL040C HEM2 SGTC_2199 6590217 200 µM 1.2485388983213 0.0924617215707565 no 366 0.105916886307089 508 703109 SGTC_3186 9110464 49.47 µM 1.24585979448778 0.0929332289944747 no 367 0.1064079364051 583 17018021 SGTC_2064 5220758 200 µM 1.2452161986664 0.0930467626369775 no 368 0.106526144897295 644 788518 SGTC_231 b-estradiol 524 µM 1.24079952901982 0.0938286530737064 no 369 0.10733990763987 512 450 A steroid. SGTC_2742 clothiapine 36.27 µM 1.24056524559596 0.0938702637068479 no 370 0.107383198722522 538 16351 An atypical antipsychotic. YIL048W NEO1 SGTC_452 diindolylmethane 8 µM 1.23407965192084 0.0950275709461257 no 371 0.108586612503868 531 3071 Inhibits expression of several cancer promoting factors. SGTC_189 3970-0742 2.116 µM 1.23196434228365 0.0954072963252356 no 372 0.108981202176878 574 2891807 SGTC_2736 butenafine 14.65 µM 1.23111367105205 0.0955603172915965 no 373 0.109140176554465 640 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_2806 7952793 58.44 µM 1.22754466239126 0.0962042885882519 no 374 0.109808973027524 599 2972490 SGTC_2101 5377231 179.231 µM 1.2273889854025 0.0962324504763876 no 375 0.109838212141751 594 2844213 SGTC_1829 berberine 14.4 µM 1.21931104136824 0.0977020732075303 no 376 0.111363079729016 582 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM 1.2188206520183 0.0977918167885861 no 377 0.111456135627326 637 2333 A French combination drug. SGTC_1799 st045822 46.1415 µM 1.21751369352582 0.0980312915113546 no 378 0.111704414804165 588 3674992 SGTC_3242 9133940 49.47 µM 1.2171269476736 0.0981022374902954 no 379 0.111777959612157 605 17248444 SGTC_2588 indole-3-carbinol 100 µM 1.21706871058252 0.0981129239589806 no 380 0.111789037160183 645 3712 Induces cell cycle arrest. SGTC_2818 7996756 12.99 µM 1.2157758696122 0.09835037911168 no 381 0.112035156683406 516 2241621 SGTC_2246 7293507 91.5585 µM 1.21015002778038 0.0993885745662978 no 382 0.113110664703435 632 887656 SGTC_576 1073-0113 22.7 µM 1.20905751901275 0.0995911122100362 no 383 0.113320374110756 787 5439563 SGTC_2181 6316240 54.2555 µM 1.20789237656936 0.0998074474198565 no 384 0.113544331155885 558 12779990 SGTC_1862 st057513 3.81 µM 1.2045399357359 0.10043181876995 no 385 0.114190478095537 591 5393163 SGTC_2589 lobaric acid 100 µM 1.20328678113449 0.100665941358712 no 386 0.114432681319257 608 73157 A novel microtubule depolymerizer. SGTC_1151 3909-8316 15.3 µM 1.20298852288081 0.100721722529516 no 387 0.114490380968693 626 800431 SGTC_2689 tacrolimus 100 µM 1.20280191511489 0.100756633946892 no 388 0.114526491766148 587 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). SGTC_3010 9080089 71.4286 µM 1.20127568865269 0.101042498523285 no 389 0.114822138854133 628 17027233 SGTC_1989 st071868 50.2 µM 1.20092615165168 0.10110805046277 no 390 0.114889924413484 624 16414057 SGTC_2504 purpurogallin 52.29 µM 1.2007514678334 0.101140822164395 no 391 0.11492381143622 577 5281571 An antioxidant. SGTC_3292 9120825 59.784 µM 1.20065482536735 0.101158956179593 no 392 0.114942562222671 631 24824900 SGTC_1146 3579-1023 7 µM 1.20035975616632 0.101214337695251 no 393 0.114999825669812 682 X1146 SGTC_1610 st001799 48.1 µM 1.19992530420998 0.101295920157645 no 394 0.115084175752573 552 621897 SGTC_588 3970-1144 52.9 µM 1.19807125023804 0.101644617516685 no 395 0.115444640063088 642 1888707 SGTC_413 propylparaben 100 µM 1.19805823783433 0.101647067882282 no 396 0.115447172760575 597 7175 A pharmaceutical preservative. SGTC_786 4544-0069 423 µM 1.19739773781852 0.101771503140644 no 397 0.115575782488809 662 748821 YLR208W SEC13 SGTC_2525 harmine 47.85 µM 1.19667066719304 0.101908608186548 no 398 0.115717472217055 561 5280953 A monoamine oxidase inhibitor SGTC_1820 st053765 18.6 µM 1.19655967846222 0.101929549356898 no 399 0.115739112276547 594 3690829 SGTC_702 1488-0190 94 µM 1.18778287240296 0.103595472515014 no 400 0.117459481978705 636 949357 SGTC_3265 9137266 49.47 µM 1.18356152639055 0.104403725097205 no 401 0.118293338876584 559 17224265 SGTC_2020 4017018 200 µM 1.18204947391096 0.104694343364502 no 402 0.118593035391018 631 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope. SGTC_529 4076-0302 30.3 µM 1.17888922060888 0.105303638773747 no 403 0.119221145292108 629 5816522 SGTC_1874 staurosporine 7.6 µM 1.17769273372472 0.105534989124466 no 404 0.119459562382849 663 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1 SGTC_2259 7964009 200 µM 1.17489421957325 0.106077539115104 no 405 0.120018519253391 592 313134 SGTC_2476 5806916 10.51 µM 1.16997489624475 0.107036131254206 no 406 0.121005535710729 625 2870194 SGTC_96 0929-0093 37.281 µM 1.16823257958775 0.107377137465567 no 407 0.121356481111119 611 6991579 SGTC_681 1642-0006 26.6 µM 1.16685700151933 0.1076469182981 no 408 0.121634061453007 613 4446530 SGTC_176 1486-1328 72.834 µM 1.16498517491021 0.108014808206743 no 409 0.122012496918137 666 22310231 SGTC_661 1304-0007 33.6 µM 1.16396460830094 0.108215771908365 no 410 0.122219177361169 632 3117130 SGTC_718 1130-0073 349 µM 1.16137330915378 0.108727243428085 no 411 0.122745059250005 676 6740020 SGTC_2616 abietic acid 100 µM 1.16025605357126 0.108948303245342 no 412 0.122972285611335 704 6708678 Abietic acid is an inhibitor of 5α-reductase. SGTC_1783 st039459 87.517 µM 1.1590901289396 0.109179337013905 no 413 0.12320972452232 714 729761 SGTC_2974 9094440 9.66 µM 1.15746862444724 0.109501231139641 no 414 0.123540475461727 676 25236134 SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM 1.14931967325615 0.111129246534537 no 415 0.125212094398738 646 6710655 SGTC_2856 9022925 19.48 µM 1.14751213407254 0.111492697396852 no 416 0.125585010549859 674 4944862 SGTC_367 0335-0881 7.1 µM 1.14658858803399 0.111678727378424 no 417 0.125775847588545 679 23828853 SGTC_2644 guaiazulene 100 µM 1.14461217894758 0.112077581508179 no 418 0.126184922494218 655 3515 A coloring agent. SGTC_722 3534-0461 190 µM 1.14401443581473 0.112198410864232 no 419 0.126308825136783 659 658262 SGTC_59 0330-0160 1.33 µM 1.14384114094199 0.112233458544241 no 420 0.126344762254638 802 4293482 SGTC_2464 5717415 7.67 µM 1.14359254804928 0.112283748385285 no 421 0.126396326780193 664 5285744 SGTC_3346 9158254 43.5805 µM 1.14117684266947 0.112773279412164 no 422 0.126898169493779 666 17639500 SGTC_1038 k292-0204 154 µM 1.13918460289577 0.113178142255308 no 423 0.127313083081144 632 4454212 SGTC_2202 7226349 200 µM 1.13805667762799 0.113407818400631 no 424 0.127548408232166 639 844334 SGTC_731 3966-0296 387 µM 1.13578148113863 0.113872121158202 no 425 0.128024014683798 669 660956 SGTC_1397 3532-0190 20.1 µM 1.13447654828662 0.11413903122694 no 426 0.128297352762155 585 5322280 SGTC_3262 9137218 49.47 µM 1.13313452051641 0.114413993145617 no 427 0.128578883322382 527 17650664 SGTC_1618 st003135 44.5 µM 1.13090301744092 0.114872238940624 no 428 0.129047956572944 654 1270615 SGTC_1150 3909-7983 10.9 µM 1.13081732097629 0.114889862958565 no 429 0.129065994032424 698 23965914 SGTC_2129 girgensonine 121.053 µM 1.12713794944354 0.115648363710242 no 430 0.129842080241914 728 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_3157 9099274 49.47 µM 1.12712836309559 0.115650344566509 no 431 0.129844106492106 664 17217662 SGTC_150 3970-0969 77.2 µM 1.12582843189758 0.115919176565551 no 432 0.130119073553339 761 6615640 SGTC_2106 5357045 167.29 µM 1.12541431426935 0.116004911189208 no 433 0.13020675407656 699 668842 SGTC_1390 3413-2614 145 µM 1.12513496869708 0.116062769420777 no 434 0.130265922593023 701 3421432 SGTC_2879 9041815 71.43 µM 1.12415480877425 0.116265942783728 no 435 0.130473678560871 578 4942971 SGTC_580 1123-0028 41 µM 1.12415384759446 0.116266142146563 no 436 0.130473882406192 769 1677248 YPR107C YTH1 SGTC_2578 7,8-dihydroxyflavone 64.44 µM 1.12395136171889 0.116308146105167 no 437 0.130516830165275 650 1880 Intensifies effect of antibiotics on Staphylococcus aureus. SGTC_2789 5281112 71.43 µM 1.12183257217028 0.116748316700752 no 438 0.130966817108752 675 765948 SGTC_3032 9089427 49.47 µM 1.11881395203044 0.117377461589648 no 439 0.131609759133493 650 17173707 SGTC_1793 st048256 72.231 µM 1.11849479786225 0.117444120211286 no 440 0.131677863541157 686 672022 SGTC_391 gliotoxin 8.33 µM 1.11606038005701 0.117953455430104 no 441 0.132198144949604 728 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion SGTC_2248 tofa 1.1 µM 1.11384337646085 0.118418660480987 no 442 0.13267319230891 658 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_841 0251-0215 91.2 µM 1.11334328891625 0.118523775394131 no 443 0.132780510651982 745 3888614 SGTC_1455 4262-0120 131 µM 1.11309877110076 0.118575195329334 no 444 0.132833005713969 726 1529587 SGTC_2460 5552655 174.22 µM 1.11123525609533 0.11896759396816 no 445 0.133233549680337 672 5401989 SGTC_1077 5-fluorocytosine 377 nM 1.11002283777788 0.119223383635197 no 446 0.133494592719475 669 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_2890 9046729 58.44 µM 1.10699861524509 0.119863109315586 no 447 0.134147263515997 631 903329 SGTC_3062 9077494 49.47 µM 1.10660341374702 0.119946886295701 no 448 0.134232715359376 679 16459633 SGTC_1527 coumarin 137 µM 1.10479556681634 0.120330649859426 no 449 0.134624090950818 640 323 A hepatotoxic, DNA x-linker. SGTC_674 0498-0004 451 µM 1.10380425337748 0.120541449271298 no 450 0.134839029699957 672 4231473 SGTC_1978 st071761 42 µM 1.10231598187329 0.12085841314426 no 451 0.135162161838264 659 5147680 SGTC_8 0354-0001 70 µM 1.10126135232936 0.121083377141211 no 452 0.135391463212789 804 4993152 SGTC_825 1988-2224 89.6 µM 1.09800408765308 0.121780046597326 no 453 0.13610135217435 725 1180859 SGTC_3219 9131112 49.47 µM 1.09361060332339 0.122724186837923 no 454 0.137062898406567 683 17612988 YMR079W SEC14 SGTC_706 4262-0057 46.9 µM 1.09332219438866 0.122786343718001 no 455 0.137126180757245 678 883298 SGTC_2955 9076254 12.21 µM 1.09267344672135 0.122926240214082 no 456 0.137268601149269 669 16459619 SGTC_2914 7968218 45.32 µM 1.09144009409271 0.123192509525003 no 457 0.137539639123885 676 2977111 SGTC_2188 6126565 140.678 µM 1.08663235872014 0.124234312391152 no 458 0.138599659204003 674 874518 SGTC_1540 guanosine 70.6 µM 1.08609118431708 0.124351965869985 no 459 0.138719326112207 684 6802 Guanosine is a purine nucleoside SGTC_2139 5578692 56.4705 µM 1.08532049938986 0.124519650318015 no 460 0.138889864858013 661 650991 YMR113W FOL3 SGTC_1913 st060213 96.1 µM 1.08516999148076 0.12455241604103 no 461 0.138923186212939 753 688959 SGTC_2184 6075246 200 µM 1.07928585402712 0.125838125123701 no 462 0.140230158509806 735 2267320 SGTC_1774 st048371 48.465 µM 1.07783783635052 0.126155937399723 no 463 0.140553065535158 738 4242727 SGTC_833 3852-0053 558 µM 1.07358556626334 0.127092462014057 no 464 0.141504234778731 793 3123681 SGTC_3131 9127911 49.47 µM 1.07100931037942 0.127662207228149 no 465 0.142082621681229 694 45595681 SGTC_1225 1216-0074 20.6 µM 1.07072349811231 0.127725524544499 no 466 0.142146886942561 733 4241466 SGTC_2886 9058944 51.95 µM 1.06771971472358 0.128392286910604 no 467 0.142823481357354 571 4949929 SGTC_2309 7664088 163.95 µM 1.06715189984431 0.128518598226983 no 468 0.142951624419928 801 704922 SGTC_709 3807-1509 243 µM 1.0588441538268 0.130376535617045 no 469 0.144835380639639 742 1886677 YPL242C IQG1 SGTC_1393 3470-5649 58.2 µM 1.0583805495888 0.130480760225344 no 470 0.144940991653652 625 4108395 SGTC_2863 9028737 58.44 µM 1.05735131825383 0.130712351505368 no 471 0.145175640196158 728 6460917 SGTC_119 0121-0043 24.815 µM 1.05702384248565 0.130786097634279 no 472 0.145250353094016 895 1092378 SGTC_2247 cerulenin 830 nM 1.05700378301674 0.130790615874624 no 473 0.145254930459788 746 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12 SGTC_837 0091-0265 12.5 µM 1.05542217907511 0.131147199587251 no 474 0.145616141834397 773 759367 SGTC_1717 st033143 58.0435 µM 1.05281855451532 0.131735666546209 no 475 0.146212079717715 774 674616 SGTC_1996 st072960 66.8 µM 1.05132069998358 0.132075033532114 no 476 0.146555661537438 795 1719405 SGTC_2827 7993847 71.43 µM 1.04919015852221 0.13255878540968 no 477 0.14704530362299 680 2985692 SGTC_329 k048-0121 21.3 µM 1.04824540547496 0.132773687296142 no 478 0.14726277789307 722 6832902 SGTC_2373 9071805 200 µM 1.04535051128667 0.133433679002159 no 479 0.147930500185322 776 10149009 SGTC_608 k048-0125 159 µM 1.04413222025995 0.133712104309765 no 480 0.148212110307731 782 6817652 YLR060W | YFL022C FRS1 | FRS2 SGTC_2145 5634607 200 µM 1.04338602527152 0.133882835024449 no 481 0.148384771605711 687 308662 SGTC_2194 5927483 104.545 µM 1.04320359769819 0.133924597553243 no 482 0.148427003793364 792 760979 SGTC_2176 5809774 33.9695 µM 1.0419479974552 0.134212280735151 no 483 0.148717894711217 794 2870539 SGTC_279 1273-0055 2.93 µM 1.04188085847069 0.134227675568244 no 484 0.148733459846505 824 2847562 SGTC_2751 anetholtrithion 17.25 µM 1.03983295397375 0.134697838705993 no 485 0.149208757993241 744 2194 A chloretic substance that stimulates the liver to produce bile. SGTC_1018 4259-0013 28.1 µM 1.03854765358934 0.134993497816246 no 486 0.149507580854557 733 6801262 SGTC_1378 2093-0007 380 nM 1.03734653056687 0.135270195567361 no 487 0.149787193892135 742 3618014 SGTC_1335 1486-0900 202 µM 1.03472637233063 0.13587513898136 no 488 0.150398358123317 779 X1335 SGTC_944 3370-0224 231 µM 1.033332451028 0.136197722008148 no 489 0.150724172947391 766 4580514 SGTC_1101 ebselen 5.29 µM 1.03303900881457 0.136265697499961 no 490 0.150792821896411 826 3194 A potent scavenger of hydrogen peroxide and hydroperoxides. SGTC_236 1509-0011 5.31 µM 1.03038011844284 0.136882683999115 no 491 0.151415801223373 989 3107280 SGTC_1139 k015-0024 46.9 µM 1.02974347379796 0.13703069811092 no 492 0.151565220973236 774 2766652 SGTC_2982 9019404 25.97 µM 1.02903064071305 0.137196555075737 no 493 0.151732638340829 634 22333232 SGTC_1193 1488-0126 41.5 µM 1.02708730994713 0.137649411821971 no 494 0.152189676788033 789 1384710 SGTC_2266 7929956 200 µM 1.02681382842116 0.137713223349656 no 495 0.152254068298802 778 2967153 SGTC_46 0329-0187a 2.197 µM 1.02496035441071 0.138146227006494 no 496 0.152690947317966 867 46494817 SGTC_2399 5884133 200 µM 1.02371810829991 0.13843695630143 no 497 0.152984219884917 746 722445 SGTC_3016 9080866 49.47 µM 1.02357734946238 0.138469925102553 no 498 0.153017474121809 790 17066299 SGTC_1892 st058411 7.36 µM 1.02298113038189 0.138609631990164 no 499 0.15315838384867 835 3934738 SGTC_2780 5215298 71.43 µM 1.0226520835571 0.138686775811346 no 500 0.153236187209336 827 2834131 SGTC_2857 9024691 58.44 µM 1.02207022046102 0.138823263053873 no 501 0.153373833253778 732 16478292 SGTC_2005 4024620 188 µM 1.0207695586056 0.139128689135532 no 502 0.1536818150592 785 236743 SGTC_2839 9003951 25.97 µM 1.01740608455716 0.13992063152837 no 503 0.154480144346217 760 2990634 SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM 1.01668506073647 0.140090797233529 no 504 0.154651637405352 759 279621 SGTC_2444 5485484 36.41 µM 1.01548426219744 0.14037450443957 no 505 0.154937522371246 821 6790631 SGTC_739 1486-1183 203 µM 1.01436607287608 0.140639044521464 no 506 0.15520405346178 820 4346692 SGTC_3330 9141424 71.43 µM 1.01281390566474 0.141006815139953 no 507 0.155574528685731 833 27261020 SGTC_254 nsc-64875 3.808 µM 1.01229775768843 0.14112925566738 no 508 0.15569785333598 811 56993 SGTC_1282 0886-0010 32.4 µM 1.01204384941563 0.141189514188466 no 509 0.155758543987206 880 2836211 YNL267W PIK1 SGTC_913 3487-1245 167 µM 1.01109314219264 0.14141529473217 no 510 0.155985926166199 751 4016153 SGTC_2664 lyso-paf C-16 73.48 µM 1.00858208502871 0.142012814144077 no 511 0.156587551326074 829 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_1556 plumbagin 1.48 µM 1.00790138049962 0.142175085433879 no 512 0.156750904424401 734 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_3137 9097352 49.47 µM 1.00376801036053 0.143163122036071 no 513 0.157745223468788 818 44120435 SGTC_1676 st018489 23.4 µM 1.00365212649484 0.143190889476121 no 514 0.157773159940021 794 3696235 SGTC_1044 1222-0021 1.78 µM 1.0035432819333 0.143216973510557 no 515 0.157799402384401 788 4306703 SGTC_2927 9011802 47.9 µM 1.00177631947726 0.143640865838245 no 516 0.158225818366797 753 43912568 SGTC_2887 9044784 58.44 µM 1.0005825783123 0.143927721800192 no 517 0.158514328097266 898 6465546 SGTC_2660 2',4'-dihydroxychalcone 17.14 µM 0.999906307648835 0.144090400961929 no 518 0.158677925799591 799 5357218 A potent inhibitor of glutathione S-transferases. SGTC_1255 0566-0045 221 µM 0.999900068906724 0.144091902289093 no 519 0.158679435538686 804 2788469 SGTC_2658 polymyxin b sulfate 77.05 µM 0.997685486629395 0.144625498736564 no 520 0.159215946523288 812 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides.  YIL048W NEO1 SGTC_2505 galangin 7.89 µM 0.996036770979202 0.145023614756376 no 521 0.159616139663455 725 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_2770 toltrazuril 17.5 µM 0.995661047392403 0.145114443991697 no 522 0.159707431162518 846 68591 Kills coccidiodes. SGTC_2931 9014674 55.67 µM 0.995187256094351 0.145229035157464 no 523 0.159822599374329 771 2996810 SGTC_41 0478-0632 82.643 µM 0.995152498106896 0.145237444121021 no 524 0.15983105041276 885 3750424 SGTC_315 k915-0449 187 µM 0.985824429983548 0.147506019443717 no 525 0.162109637681908 898 20970215 YNL149C PGA2 SGTC_1023 4482-3888 16 µM 0.984994052327955 0.147709110830455 no 526 0.162313496234505 814 3303168 SGTC_566 0958-0068 16.5 µM 0.984628327335551 0.147798618174345 no 527 0.162403335001952 743 6815365 SGTC_3224 9130643 49.47 µM 0.981990663269182 0.148445234062189 no 528 0.163052223993395 778 17644395 SGTC_2759 disulfiram 3.38 µM 0.980875505047182 0.148719180109118 no 529 0.163327069073131 767 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_2150 5556613 200 µM 0.98013780417544 0.148900586834812 no 530 0.163509050245944 856 743190 SGTC_1118 chelidonine 707.474 nM 0.978794492263568 0.149231297908627 no 531 0.163840765826153 883 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor. SGTC_1181 1222-0449 220 µM 0.977510403270617 0.14954788702482 no 532 0.164158264978733 836 658318 SGTC_797 k781-0471 270 µM 0.977457543104114 0.149560929172587 no 533 0.164171343536362 838 23738129 SGTC_2167 5876490 200 µM 0.97145196325576 0.151047623711447 no 534 0.165661631506443 842 686534 SGTC_1235 benzylparaben 21.5 µM 0.970860146143493 0.151194659812959 no 535 0.165808963290786 792 7180 SGTC_2405 ticlatone 3.52 µM 0.96840430497072 0.151805827066214 no 536 0.166421245157772 830 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W SGTC_2475 5812728 15.03 µM 0.96776465410962 0.15196528139246 no 537 0.166580960031119 895 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2 SGTC_1534 6-azauridine 81.6 µM 0.966566097492014 0.152264361075281 no 538 0.166880494747112 897 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1 SGTC_132 0417-1715 25.805 µM 0.966125527813646 0.152374395995992 no 539 0.166990686049124 869 6769098 SGTC_2937 9044753 11.33 µM 0.965497160237273 0.1525314258671 no 540 0.167147928831816 876 6465530 YGL099W LSG1 SGTC_2865 9030313 51.95 µM 0.964262856579607 0.152840192466914 no 541 0.167457078955846 774 42562754 SGTC_3144 9087057 49.47 µM 0.96319707471814 0.15310713581772 no 542 0.167724316433122 825 17249618 SGTC_84 0443-0269 128.823 µM 0.961985920821501 0.15341086498677 no 543 0.168028338134289 857 6150058 SGTC_20 0481-0013 4.944 µM 0.960650179393329 0.153746300315228 no 544 0.168364044564354 855 182045 SGTC_1070 indatraline 8.81 µM 0.960184850727582 0.153863268968374 no 545 0.168481094954659 832 10314472 A monamine transport inhibitor. YGL099W LSG1 SGTC_2969 9091408 28.7 µM 0.959941553813334 0.153924449424632 no 546 0.168542315531581 791 4286311 SGTC_422 cantharidin 155 µM 0.958935923435801 0.154177500199234 no 547 0.168795513073471 827 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_1720 st037298 9.481 µM 0.955974760776206 0.154924226533366 no 548 0.169542493013632 804 597396 SGTC_1568 digitonin 820 nM 0.955079269476588 0.155150515207672 no 549 0.169768805795126 896 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1 SGTC_1666 st014829 29 µM 0.953173183469844 0.155632905125451 no 550 0.170251165558468 882 3858230 SGTC_248 streptozotocin 5.23457 mM 0.951642271533158 0.156021062020532 no 551 0.170639217845872 891 5300 DNA alkylating agent. SGTC_1134 3477-0009 42.5 µM 0.950081835426204 0.15641736070546 no 552 0.171035336085502 887 3973534 SGTC_1817 st052116 64.4 µM 0.947316393758549 0.157121317621761 no 553 0.171738789789485 844 4361398 SGTC_934 2950-0684 338 µM 0.947089493712362 0.157179168501605 no 554 0.171796588955896 901 1121253 SGTC_2110 5483698 200 µM 0.944645936639167 0.157803070139101 no 555 0.172419833299595 846 2848765 YHR062C RPP1 SGTC_298 1391-0729 10 µM 0.944064232229333 0.15795183327944 no 556 0.172568412868807 849 3237558 SGTC_1311 1190-0148 100 µM 0.944018367067227 0.157963566597634 no 557 0.172580131269468 978 1961333 SGTC_2282 7944268 200 µM 0.94263645911864 0.158317357441337 no 558 0.172933442219903 866 2970414 SGTC_3245 9134821 49.47 µM 0.940971251386111 0.15874436778508 no 559 0.173359795953287 877 17014901 SGTC_959 1222-0044 107 µM 0.933648973213874 0.160630975581059 no 560 0.175242497197159 883 6083612 SGTC_1974 st069448 26.9 µM 0.93104577714693 0.161305211407166 no 561 0.175914942545314 864 6323587 YNR016C ACC1 SGTC_2891 9063876 19.48 µM 0.930458613792412 0.161457543299991 no 562 0.176066841375504 830 6472478 SGTC_1349 flufenamic acid 69 µM 0.930083344567339 0.161554951136959 no 563 0.176163966794295 835 3371 A non-steroidal anti-inflammatory. SGTC_174 3553-0389 74.3 µM 0.929653574177594 0.161666552778511 no 564 0.176275239598162 809 738071 SGTC_2543 pimpinellin 60.67 µM 0.929480768237833 0.161711440730451 no 565 0.176319993701407 839 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo. SGTC_2767 sibutramine 71.45 µM 0.928485788386945 0.161970054027011 no 566 0.176577818165606 905 64765 A serotonin-norepinephrine reuptake inhibitor.  SGTC_662 k832-1615 104 µM 0.927441057763474 0.162241888242804 no 567 0.17684879077889 851 5878478 SGTC_512 prima-1 270 µM 0.927278692043017 0.162284161726619 no 568 0.176890927290432 923 322968 A re-activator of the apoptotic function of mutant p53. SGTC_1119 parthenolide 318.541 nM 0.925589400800028 0.162724410379407 no 569 0.177329701857208 932 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs. SGTC_1969 st069479 40.1 µM 0.925216301733554 0.162821748905242 no 570 0.177426702754175 848 3895485 SGTC_1805 st050013 60.3 µM 0.923705596096552 0.163216266744519 no 571 0.177819808858057 856 4037144 SGTC_1888 azatryptophan 97.5 µM 0.922075877094825 0.163642560584823 no 572 0.178244499363817 800 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides SGTC_2735 sertaconazole 140 nM 0.921257400116539 0.163856926186164 no 573 0.178458028231667 865 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C SGTC_1859 st055998 20 µM 0.920469597702314 0.164063429918442 no 574 0.178663706673265 923 676301 SGTC_2948 9070189 9.45 µM 0.918792727795131 0.16450354348935 no 575 0.179101998471711 809 6473636 YDL196W YDL196W SGTC_1189 1431-2119 7.28 µM 0.917868264138848 0.164746506401545 no 576 0.1793439191144 919 3107275 SGTC_3129 9127257 49.47 µM 0.917799884050363 0.164764486942932 no 577 0.179361821490574 748 837894 SGTC_2515 chrysin 20.77 µM 0.915507999823594 0.165367873091912 no 578 0.179962502346582 910 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor. SGTC_3218 9131285 49.47 µM 0.909486621106934 0.166959929147301 no 579 0.181546658387112 959 17156417 SGTC_1841 st054148 70 µM 0.908716090511235 0.167164368983518 no 580 0.181750004229754 835 675442 SGTC_491 tetrandrine 80.3 µM 0.90870293520756 0.167167860794698 no 581 0.1817534771992 874 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_914 3820-6779 408 µM 0.90820527206415 0.167299990017697 no 582 0.181884889598561 895 2893481 SGTC_421 streptovitacin 30 mM 0.907836816312938 0.167397858119502 no 583 0.181982221906995 924 91467 include heat shock SGTC_2088 5278280 127.392 µM 0.907464218092545 0.167496864040031 no 584 0.182080681615823 918 791502 SGTC_2629 bisabolol 100 µM 0.906898426486393 0.16764727697307 no 585 0.182230256671584 918 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer. SGTC_3117 9124945 49.47 µM 0.906845926260131 0.167661238310907 no 586 0.182244139745218 810 17592065 SGTC_2807 7945238 51.95 µM 0.906167149218796 0.167841812300644 no 587 0.182423693947021 889 17148797 SGTC_25 0118-0223 35.662 µM 0.902174581471569 0.168906481839081 no 588 0.183482067597946 909 5333628 SGTC_427 1354-0053 47.3 µM 0.901668921087918 0.169041631556751 no 589 0.183616383607991 881 6813657 SGTC_3039 9090270 49.47 µM 0.900455686220959 0.169366180458449 no 590 0.183938898829239 897 17173750 SGTC_895 0964-0006 13.7 µM 0.90027155464563 0.169415471887899 no 591 0.183987877490922 908 6738897 SGTC_95 0471-0001 561.058 µM 0.899685581452064 0.169572396284438 no 592 0.184143799321615 894 4015405 SGTC_2187 6125751 200 µM 0.897517515931652 0.170153817603514 no 593 0.184721415525574 922 874498 SGTC_1260 0700-1617 7.75 µM 0.895588159987957 0.170672295866603 no 594 0.185236380794296 911 2853078 SGTC_951 1171-0579 82.7 µM 0.888568952205172 0.172567097959005 no 595 0.187117391670974 959 1616050 YPR165W | YDR526C RHO1 | YDR526C SGTC_1295 1013-0063 9.78 µM 0.885150714280876 0.173494673196437 no 596 0.188037675057478 964 6826038 SGTC_263 alizarin 107.927 µM 0.884229106824827 0.173745303298514 no 597 0.188286274446259 986 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. SGTC_210 3551-0445 56.827 µM 0.883975433654465 0.173814329830952 no 598 0.188354737193518 923 2865180 YOR207C RET1 SGTC_2523 spermine 47.74 µM 0.883074640484052 0.17405958388972 no 599 0.188597972396684 927 1103 A DNA binding polyamine. SGTC_2082 5219693 150 µM 0.881710525493755 0.174431402656703 no 600 0.188966683807285 943 2834649 SGTC_250 brefeldin a 552.239 µM 0.881223394218945 0.174564302888052 no 601 0.189098459754234 838 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.  SGTC_366 0181-0206 4.31 µM 0.88114444598836 0.174585847772542 no 602 0.189119821703012 970 274874 SGTC_1581 himbacine 57.9 µM 0.880773545149347 0.17468708879964 no 603 0.189220200583976 905 5281825 An alkaloid muscarinic receptor antagonist. SGTC_1956 st077085 54 µM 0.880359754418255 0.174800081022824 no 604 0.189332225691267 952 24208685 SGTC_1993 st073995 70.8 µM 0.876982062700182 0.175724148371569 no 605 0.190248190464896 954 3098394 SGTC_1946 st076057 65.1 µM 0.875274594278091 0.176192452284667 no 606 0.190712257081504 830 953009 SGTC_2263 7948595 193.29 µM 0.873125275537131 0.176783063425128 no 607 0.191297399263915 876 2971371 SGTC_245 methotrexate 289.6 µM 0.872468332027912 0.176963834318542 no 608 0.191476468471206 962 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2 SGTC_879 0831-1030 162 µM 0.872421017604431 0.176976858318048 no 609 0.191489369367597 942 1549252 SGTC_2567 aureobasidin a 60 nM 0.871867104735892 0.177129376131067 no 610 0.191640440564656 905 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1 SGTC_1361 1608-0041 5.61 µM 0.8712553011732 0.177297930395329 no 611 0.191807385370321 937 X1361 SGTC_798 1287-0182 476 µM 0.871121669738268 0.177334759849096 no 612 0.191843861654572 1011 1649755 SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM 0.87073791891973 0.17744055023693 no 613 0.191948634595771 967 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_1209 2323-2347 50.3 µM 0.870134994553308 0.177606841675194 no 614 0.192113317759907 958 5412760 SGTC_2682 pyrogallin 40.03 µM 0.868714035416632 0.177999142615912 no 615 0.192501781302357 1021 822798 An ATP competetive kinase inhibitor. SGTC_1887 st057648 70.8 µM 0.868060565326345 0.178179737078436 no 616 0.192680588832048 953 688672 SGTC_1721 st082152 9.2685 µM 0.867261972178745 0.178400594825805 no 617 0.192899243808097 918 5296051 SGTC_800 3448-7362 155 µM 0.867220271545258 0.178412132227974 no 618 0.192910665612611 1112 15991913 SGTC_725 1497-0963 19 µM 0.866982565401267 0.17847790786449 no 619 0.192975781219195 985 3549977 SGTC_1090 efavirenz 20.7 µM 0.866261143572553 0.17867762591941 no 620 0.193173484785481 952 64139 A non-nucleoside reverse transcriptase inhibitor. SGTC_2463 5473429 200 µM 0.865125146110546 0.178992400013203 no 621 0.193485052129625 925 5399405 SGTC_1178 0988-0033 191 µM 0.86424596709779 0.179236251530076 no 622 0.193726392782954 946 5392207 SGTC_2283 7944793 200 µM 0.863666172381404 0.179397179264269 no 623 0.193885650781836 986 2970533 SGTC_3208 9114115 49.47 µM 0.863241236182799 0.179515182160461 no 624 0.194002422902842 860 650895 SGTC_9 0092-0002 10.449 µM 0.862323236701173 0.179770273041967 no 625 0.194254834654692 950 759368 SGTC_122 0236-0016 402.397 µM 0.86226004190237 0.179787841792583 no 626 0.19427221795567 1030 6808838 SGTC_3284 9108171 64.8615 µM 0.862115757291632 0.179827958318838 no 627 0.194311910576292 897 8687505 SGTC_3230 9131665 49.47 µM 0.857509967480525 0.18111149380528 no 628 0.195581554293938 904 15943720 SGTC_600 1495-0418 41.6 µM 0.85591069027046 0.181558517381379 no 629 0.196023590683092 936 5377768 SGTC_3179 9107801 49.47 µM 0.854970940939824 0.181821514181572 no 630 0.196283617594894 983 4818259 SGTC_3007 9078383 71.4286 µM 0.854524917739763 0.181946420895962 no 631 0.196407104537421 967 6496995 SGTC_2032 5185112 25.99 µM 0.851934117284568 0.182673023144945 no 632 0.197125329794919 932 5718189 SGTC_23 0213-0011 39.996 µM 0.85007372294953 0.183195895540435 no 633 0.197642049899086 971 627608 SGTC_1411 3909-8223 150 µM 0.84920826820174 0.183439453390996 no 634 0.197882706647118 1038 X1411 SGTC_1385 3091-4834 14.1 µM 0.848812819342241 0.183550808486185 no 635 0.19799272789241 926 4072814 SGTC_2558 carylophyllene oxide 100 µM 0.846293518587581 0.184261211271621 no 636 0.198694511334155 1060 6708694 An oxygenated terpenoid and antifungal agent. SGTC_1396 3511-0007 98.6 µM 0.843864940989465 0.184947648898117 no 637 0.199372440602567 893 X1396 SGTC_134 0269-0018 6.916 µM 0.841461004090429 0.185628684546886 no 638 0.200044861178184 902 4378915 SGTC_2070 5230947 200 µM 0.839994841324935 0.18604481156983 no 639 0.20045563946621 1068 2835538 SGTC_3205 9113483 49.47 µM 0.838776175352511 0.186391133673663 no 640 0.200797461251957 980 17018033 SGTC_194 1486-1323 56.904 µM 0.838611307821588 0.186438016595343 no 641 0.200843731546976 993 5178754 SGTC_620 0109-0052 432 µM 0.837762148278253 0.186679605414276 no 642 0.201082150647135 1012 493037 SGTC_2229 7354935 190 µM 0.831400928423188 0.188495552511332 no 643 0.202873587382065 969 318112 SGTC_2833 9001315 45.46 µM 0.830382921841871 0.188787172270091 no 644 0.203161159139404 966 2989378 SGTC_2402 5553605 200 µM 0.830150814718394 0.188853700944068 no 645 0.203226760007828 1014 6758546 SGTC_3001 9076041 71.4286 µM 0.828139488172056 0.1894308106394 no 646 0.203795754258441 980 16004211 SGTC_22 0964-0034 14.468 µM 0.823802575226523 0.190678888702046 no 647 0.205025872058615 1049 138402 SGTC_2601 securinine 100 µM 0.823466626356948 0.190775778330129 no 648 0.205121344101691 966 442872 A GABA receptor antagonist. SGTC_2628 lathosterol 100 µM 0.823297066050174 0.190824691988907 no 649 0.205169540837155 1031 6710616 SGTC_1954 st077032 68.9 µM 0.822279377151353 0.19111842994896 no 650 0.205458955585323 951 698907 SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM 0.821450543851932 0.191357862800366 no 651 0.205694841788646 976 17037758 SGTC_1726 st035556 14.5795 µM 0.819880711299538 0.191811858607367 no 652 0.206142056865539 1034 5919439 SGTC_552 k242-0005 476 µM 0.817086582048583 0.192621550971728 no 653 0.206939475192766 992 4088318 SGTC_1306 1185-0270 9.02 µM 0.816931584822985 0.192666527669015 no 654 0.206983763325747 1042 1548076 SGTC_1465 k213-0056 144 µM 0.81494134960406 0.19324461914326 no 655 0.20755294141046 955 24048857 YMR208W ERG12 SGTC_1848 st056003 16.4 µM 0.813694265057009 0.193607391096751 no 656 0.207910060190286 1109 146492 SGTC_2388 9080168 200 µM 0.811818157939353 0.194153924977197 no 657 0.208447990660479 949 15943073 SGTC_1027 k015-0025 8.67 µM 0.810789671176927 0.194453934652309 no 658 0.208743233519654 1046 3598955 SGTC_2923 7992654 58.14 µM 0.805858910932393 0.195896153185141 no 659 0.210162102724705 1003 2985126 SGTC_371 0195-0006 7.36 µM 0.805356958330008 0.196043334499525 no 660 0.21030686097166 932 3928593 SGTC_3253 9135987 49.47 µM 0.803196175818729 0.196677679354998 no 661 0.210930677754952 977 4182430 SGTC_536 3852-0578 10.6 µM 0.801634756917442 0.197136840831885 no 662 0.211382133061548 1064 2869208 SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM 0.801553006796258 0.19716089868521 no 663 0.211405785172835 1026 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair. SGTC_2177 5811945 192 µM 0.800614694037789 0.197437157463883 no 664 0.211677370700988 1058 5343475 SGTC_1554 st069299 38.7 µM 0.799516390318558 0.197760818080082 no 665 0.211995523322007 1068 24207999 SGTC_2114 5491910 81.25 µM 0.798385916163665 0.198094293661947 no 666 0.21232328685248 1043 2849228 SGTC_2148 5546263 113.568 µM 0.798315555262918 0.198115060456098 no 667 0.21234369669457 1035 792097 SGTC_1403 3909-7815 62.9 µM 0.796059021370156 0.198781766057982 no 668 0.212998865448702 1012 6615483 SGTC_199 4063-0024 41.6 µM 0.794311475858336 0.199299016405015 no 669 0.213507062438666 1073 306215 SGTC_2434 5670830 169.91 µM 0.794219814589004 0.199326169280202 no 670 0.21353373758909 1001 1549830 SGTC_2502 avocadyne acetate 18.59 µM 0.794072439034552 0.199369831102698 no 671 0.213576630713895 1098 3952079 SGTC_1298 1079-1278 263 µM 0.791887313941627 0.200017876735572 no 672 0.214213192323299 1074 2840950 SGTC_185 k048-0037 25.491 µM 0.790493760722412 0.200431825360664 no 673 0.214619732288926 1089 6827589 SGTC_2837 9008476 45.46 µM 0.790255284525146 0.200502715155563 no 674 0.21468934763457 1047 2992805 SGTC_3287 9117173 37.0625 µM 0.790072836196076 0.200556960187018 no 675 0.214742616331003 1034 2789709 SGTC_985 1493-0307 8.71 µM 0.789059056766493 0.200858534770629 no 676 0.215038745249264 1036 3278274 SGTC_2233 sulbentine 40.3845 µM 0.787085987384608 0.201446254273653 no 677 0.21561576582538 1080 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58 SGTC_1776 st049249 45.9 µM 0.787029710547595 0.201463032595405 no 678 0.215632237042945 1096 1822314 SGTC_2843 9000894 45.46 µM 0.784688589574264 0.20216175393548 no 679 0.21631808723138 957 2242070 SGTC_423 5-fluorouracil 457 µM 0.782694305890806 0.202758101714917 no 680 0.216903323397872 1009 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_1806 st050005 60.3 µM 0.781886407544016 0.202999985235557 no 681 0.217140666930722 1043 5194765 SGTC_2262 9014885 67.46 µM 0.780259605795613 0.203487569707385 no 682 0.217619042030206 1018 6457424 SGTC_2021 4019055 173 µM 0.779782975806427 0.203630557300993 no 683 0.217759314303323 1104 44827708 YER133W GLC7 SGTC_2069 5228469 200 µM 0.777594540715981 0.204287850090935 no 684 0.218404040221826 1031 2835210 SGTC_921 1561-0023 372 µM 0.777181986333179 0.204411901474634 no 685 0.218525704233404 1134 24050882 SGTC_1708 st033234 31.827 µM 0.77691567384351 0.204492003048723 no 686 0.218604261621475 1124 674664 SGTC_855 0428-0020 25 µM 0.776481131540351 0.204622744953297 no 687 0.218732478675175 1001 6812414 SGTC_2025 5147754 141 µM 0.774879958176592 0.205104923329115 no 688 0.219205297963975 1064 315777 YLR208W SEC13 SGTC_1449 4112-4002 201 µM 0.77336522706906 0.205561691404532 no 689 0.219653131570624 1047 2059539 SGTC_1552 6-methylflavone 10.6 µM 0.772304230404146 0.205881994936219 no 690 0.219967130219891 1051 689013 SGTC_3313 9133968 57.047 µM 0.771792675107222 0.206036533736287 no 691 0.220118615391444 1092 1494643 SGTC_1079 idarubicin 2.36 µM 0.770936844095618 0.206295230607989 no 692 0.220372183535198 1045 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_2913 7966556 36.57 µM 0.770916328223253 0.206301434418388 no 693 0.220378264092871 1035 2976516 SGTC_372 0155-0182 15.9 µM 0.769530016786471 0.206720898319109 no 694 0.220789366119171 1108 771486 SGTC_2407 paclitaxel 400 µM 0.7667067485335 0.20757670998101 no 695 0.221627945170214 1079 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_2671 danthron 100 µM 0.766444870392771 0.20765619854651 no 696 0.221705821458007 1070 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin. SGTC_1277 0873-0036 22 µM 0.7656447912276 0.207899160071005 no 697 0.221943842669496 1123 5965735 SGTC_2647 atorvastatin 60.16 µM 0.7648676819306 0.20813530691458 no 698 0.222175170042967 1051 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7 SGTC_1066 ketoconazole 628 nM 0.762943053825962 0.208720841194608 no 699 0.222748679102088 1133 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W SGTC_1346 1488-2224 62.4 µM 0.761094971350325 0.209284000443105 no 700 0.223300171911421 1101 3722427 SGTC_2423 st077119 87.2 µM 0.760333201824327 0.20951639167128 no 701 0.223527720216634 1091 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae). SGTC_1513 0337-0559 19 µM 0.760004735291207 0.209616643001285 no 702 0.223625877192271 1039 775073 SGTC_2553 4-methylesculetin 85.09 µM 0.753608409639011 0.211574484219225 no 703 0.225542196565332 1146 5319502 SGTC_1259 0671-0132 43 µM 0.753152547155588 0.211714425933751 no 704 0.22567912543384 1046 X1259 SGTC_259 usnic acid 108.925 µM 0.750773538643797 0.21244561795675 no 705 0.22639447851711 1159 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_3178 9107506 49.47 µM 0.750176507121646 0.212629347860016 no 706 0.226574202993819 1095 8897194 SGTC_493 zm226600 134 µM 0.747491338441479 0.213456825433658 no 707 0.227383514619095 1147 5240098 A potassium channel opener. YCR052W RSC6 SGTC_232 clozapine 119 µM 0.746948252995257 0.2136244137825 no 708 0.227547398710281 1077 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_752 1896-0090 130 µM 0.746257544366053 0.213837667226449 no 709 0.227755926347126 1111 772567 SGTC_2083 5306046 65.942 µM 0.746033980759597 0.213906718115516 no 710 0.22782344410768 1132 539837 SGTC_1248 0469-0687 58.6 µM 0.744951359327285 0.214241285174663 no 711 0.22815056258322 1115 4017482 SGTC_584 0986-0246 15.4 µM 0.744853847416984 0.21427143462824 no 712 0.228180039163223 1217 53315 YDR232W HEM1 SGTC_1136 pergolide 1.05886 µM 0.744807007178734 0.214285917916996 no 713 0.228194199118208 1071 47811 A dopamine receptor agonist. SGTC_2994 9053520 71.4286 µM 0.744254834605381 0.214456695980852 no 714 0.228361159900014 1106 4647384 SGTC_497 capsazepine 133 µM 0.744214763830235 0.214469092303925 no 715 0.228373278797595 1119 2733484 A calcium channel blocker. SGTC_1353 1498-1206 8.11 µM 0.743928349350811 0.214557709818918 no 716 0.228459911746458 1163 6756808 SGTC_2196 6573537 42.6665 µM 0.743903939433279 0.214565263306202 no 717 0.228467295966952 1138 2903087 SGTC_168 3970-0862 530.542 µM 0.743130304142257 0.21480473969721 no 718 0.228701397087886 1164 3135186 SGTC_3118 9124250 49.47 µM 0.74272755233762 0.214929471699368 no 719 0.228823322596168 1012 1504786 SGTC_1275 0867-0008 21.1 µM 0.742171749802396 0.215101672489349 no 720 0.228991641227391 1115 3422836 SGTC_2798 7813637 45.45 µM 0.741834072585585 0.215206331992207 no 721 0.229093936940184 1097 956368 SGTC_3288 9119690 36.221 µM 0.740938027477688 0.215484194983573 no 722 0.22936550847088 1099 17595618 YKL019W RAM2 SGTC_2212 7123476 200 µM 0.739084861751323 0.21605952020069 no 723 0.229927734295333 1080 1085715 SGTC_495 decylubiquinone 155 µM 0.739083446184257 0.21605996001087 no 724 0.229928164054191 1106 2971 A Co-enzyme Q analog. A free radical scavenger. SGTC_1380 2291-0730 164 µM 0.738892948689194 0.216119151437325 no 725 0.229986002212334 1131 2999191 SGTC_2741 miltefosine 3.04 µM 0.735309022196147 0.217234499089079 no 726 0.23107565736901 1029 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis. SGTC_672 1441-0018 53.7 µM 0.734885119881348 0.217366640528137 no 727 0.231204730693592 1116 251141 SGTC_1052 3253-3998 198 µM 0.734284857398689 0.217553837415796 no 728 0.231387572427711 1136 5450317 SGTC_1880 MG-132 525 µM 0.734272069691518 0.217557826381443 no 729 0.23139146847829 1081 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1 SGTC_2377 9073351 62.6 µM 0.731900514423145 0.218298332981943 no 730 0.23211464609111 1115 7337946 YHR072W ERG7 SGTC_2985 9022375 71.43 µM 0.731733895500668 0.218350413467361 no 731 0.232165501808832 1182 4939335 SGTC_246 cycloheximide 667 µM 0.730750244956433 0.218658021349992 no 732 0.232465859678138 1049 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells. SGTC_2274 7947094 46.08 µM 0.730650039971839 0.218689371516284 no 733 0.232496469411783 1164 2971028 SGTC_866 0495-0101 262 µM 0.728783434350974 0.219273831178056 no 734 0.233067073169944 1111 635694 SGTC_3181 9108277 49.47 µM 0.728157968745938 0.219469873617038 no 735 0.233258445904863 1118 17097298 SGTC_1771 st048882 4.1505 µM 0.727902879257885 0.219549856336765 no 736 0.23333652026702 1134 4580403 SGTC_765 1319-0117 244 µM 0.727404849429688 0.2197060606815 no 737 0.233488992326082 1138 3487746 YGL099W LSG1 SGTC_324 1315-0088 19.6 µM 0.727397787330153 0.219708276129306 no 738 0.233491154788368 1094 6787421 SGTC_1586 deoxycorticosterone acetate 53.7 µM 0.726871097222334 0.219873539972775 no 739 0.233652462139384 1142 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE. SGTC_1048 3161-0300 24.5 µM 0.726673695403785 0.219935498724784 no 740 0.233712935548366 1188 2165101 SGTC_507 nimesulide 162 µM 0.725358206338527 0.220348648663389 no 741 0.234116152855571 1146 4495 A COX2 inhibitor. SGTC_2142 5622915 118.518 µM 0.725207105938303 0.220396132579905 no 742 0.234162492067784 1130 5322196 SGTC_3026 9090633 49.47 µM 0.724645470145455 0.220572680324684 no 743 0.23433477808446 1160 25236842 SGTC_301 4119-0100 24.5 µM 0.724165122271954 0.220723739833175 no 744 0.23448218406073 1166 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1 SGTC_1853 st056710 91.2 µM 0.723928507544042 0.220798172066 no 745 0.234554813676426 1205 269167 SGTC_1050 3232-1156 69.3 µM 0.722573265448382 0.221224769329088 no 746 0.234971049046467 1106 700529 SGTC_1423 4048-0112 5.59 µM 0.722413453161101 0.221275105409872 no 747 0.235020159065183 1162 X1423 SGTC_341 1486-1430 230 µM 0.722210500332238 0.221339038909264 no 748 0.235082534264655 1142 2054753 YPL210C SRP72 SGTC_943 3253-1379 105 µM 0.722013234918305 0.221401190901573 no 749 0.235143170265629 1120 668464 SGTC_646 4092-0839 27.3 µM 0.721735622577718 0.221488674529415 no 750 0.235228518162015 1186 877796 SGTC_2038 4100038 30.985 µM 0.721210773660888 0.221654123493326 no 751 0.235389922093987 1136 3596803 SGTC_1930 st074634 34.3 µM 0.720295288552257 0.221942882289389 no 752 0.235671602490422 1145 684253 YOR116C RPO31 SGTC_3103 9120822 49.47 µM 0.719270734175427 0.222266297867647 no 753 0.235987062113656 1215 17141819 SGTC_2011 4012611 177 µM 0.718411028348321 0.222537883948976 no 754 0.236251944423847 1191 2049887 SGTC_1670 st016595 4.04 µM 0.717758635866465 0.222744104751068 no 755 0.236453061034434 1172 597879 SGTC_332 4112-0506 40.9 µM 0.717757837083461 0.222744357312547 no 756 0.2364533073374 1154 2790355 SGTC_2792 7535235 81.82 µM 0.717649121020865 0.222778732988665 no 757 0.236486831011467 1134 1281891 SGTC_3282 9108498 15.4605 µM 0.717453756386184 0.222840514266954 no 758 0.236547080203757 1132 16459645 SGTC_1843 st055809 45.5 µM 0.717336543284621 0.222877585922881 no 759 0.236583232021294 1135 16413835 SGTC_1775 st081588 35.1725 µM 0.716708772031327 0.22307619450782 no 760 0.236776906066531 1206 1426443 YGL099W LSG1 SGTC_2790 5423970 71.43 µM 0.715931537624382 0.223322228461834 no 761 0.237016811821681 1176 1376240 YKL165C | YIL048W MCD4 | NEO1 SGTC_2102 5377816 72.7585 µM 0.715677212402343 0.223402768762633 no 762 0.237095342343607 1185 1379702 SGTC_824 1304-0008 100 µM 0.715486993455264 0.223463018541237 no 763 0.237154087479413 1161 768245 SGTC_2481 5478948 45.16 µM 0.715305811368252 0.22352041458743 no 764 0.237210049205314 1159 77792 SGTC_2447 5741742 33.78 µM 0.714855920658253 0.223662970164242 no 765 0.237349038348959 1173 1776504 SGTC_1923 st058458 19.1 µM 0.712223953463143 0.224497989209791 no 766 0.238163053136808 1209 3534982 SGTC_950 1165-0508 94.1 µM 0.708693054611643 0.225620977100076 no 767 0.239257487905735 1154 6148369 SGTC_627 1391-0720 175 µM 0.707160289410244 0.226109454457324 no 768 0.239733436586935 1125 997839 SGTC_141 0443-0274 32.331 µM 0.706744765059798 0.226241980931106 no 769 0.239862552653811 1281 1627241 SGTC_3013 9080133 71.4286 µM 0.706044350195051 0.226465469094603 no 770 0.240080278708879 1242 17050193 SGTC_2323 6148992 148.28 µM 0.705879068423411 0.226518225325598 no 771 0.240131672749425 1146 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42 SGTC_3202 9113761 49.47 µM 0.70575061083545 0.22655923244979 no 772 0.240171620524088 1204 4798415 SGTC_3116 9124943 49.47 µM 0.705253873051315 0.226717843968084 no 773 0.240326130249884 1105 41905195 YPL160W CDC60 SGTC_1746 st038117 42 µM 0.705078853698779 0.226773743679832 no 774 0.240380582720363 1172 2898218 SGTC_65 0798-0905 34.986 µM 0.704736971883098 0.226882960289965 no 775 0.240486969252447 1263 3602145 SGTC_3180 9109287 49.47 µM 0.703193738312155 0.22737632644251 no 776 0.240967510477851 1173 18891271 SGTC_2132 5317594 122.667 µM 0.702583361517012 0.227571628357293 no 777 0.241157717252032 1158 794577 SGTC_2324 6149169 200 µM 0.700237879833078 0.228322989037784 no 778 0.241889379494192 1125 2888231 SGTC_2615 purpurogallin-4-carboxylic acid 100 µM 0.700175447579651 0.228343007859029 no 779 0.241908871390485 1232 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase. SGTC_333 3486-0131 40.1 µM 0.699661186410109 0.228507942559248 no 780 0.24206946064394 1243 6744690 SGTC_759 3486-0358 89.3 µM 0.698995266512682 0.22872161690557 no 781 0.24227749450549 1221 875103 SGTC_265 mycophenolic acid 32.932 µM 0.697526300462434 0.229193361874286 no 782 0.242736742990365 1281 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1 SGTC_2 0422-0095 29 µM 0.697446390670594 0.229219039809684 no 783 0.242761739001611 1092 6790840 SGTC_2049 5262831 67.185 µM 0.696826865372986 0.229418170646658 no 784 0.242955575547173 1220 763417 SGTC_1075 aripiprazole 15.2 µM 0.696702167030733 0.229458263513466 no 785 0.242994601177949 1229 60795 An atypical antipschotic. YIL048W NEO1 SGTC_2657 nystatin 74.44 µM 0.696378932684117 0.229562207725408 no 786 0.243095776481117 1213 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM 0.695377157271134 0.229884521566929 no 787 0.243409485992982 1183 803109 SGTC_531 3788-1495 174 µM 0.694577076884042 0.230142123380432 no 788 0.243660191021497 1162 2896655 SGTC_1942 st076330 65.2 µM 0.693969271335743 0.230337926370701 no 789 0.243850739920177 1236 24208414 SGTC_1099 5-nonyloxytryptamine 2.85 µM 0.693804866571172 0.230390904942851 no 790 0.243902295131491 1171 23581825 A 5-HT1D beta serotonin receptor agonist. SGTC_1301 naphtanilide LB 4.81 µM 0.692092242128024 0.230943194123923 no 791 0.244439701630107 1244 67238 An a1-adrenergic receptor antagonist or alpha blocker. SGTC_1866 st057638 64 µM 0.691963461592993 0.230984753283908 no 792 0.244480137605521 1187 688802 SGTC_2018 5133068 143 µM 0.690866406813673 0.231338956404563 no 793 0.24482474939294 1202 785362 SGTC_1811 st050069 61.5 µM 0.690458663388646 0.231470680604857 no 794 0.244952898208587 1192 3877702 SGTC_1836 st055642 81 µM 0.689682650662416 0.231721492120316 no 795 0.245196889276482 1185 8571 SGTC_1981 st071826 47 µM 0.689593958192009 0.231750167646399 no 796 0.245224783955894 1170 11838600 SGTC_1191 1487-1166 10.6 µM 0.68895353958635 0.231957282678814 no 797 0.24542625271773 1267 3955771 SGTC_2439 5492030 7.2 µM 0.688620613541491 0.232064993567996 no 798 0.245531022775603 1176 5722370 SGTC_1899 st063254 59.6 µM 0.687880101935431 0.232304669601309 no 799 0.245764143974244 1155 3093813 SGTC_1821 st053465 65.6 µM 0.685626759132649 0.233034839229346 no 800 0.246474251427085 1180 675086 SGTC_1409 3909-8004 61.9 µM 0.684532401331896 0.233389912453696 no 801 0.246819518213296 1225 2119279 SGTC_991 3996-0057 64.7 µM 0.684170264911035 0.233507476603464 no 802 0.246933828216534 1192 715343 SGTC_770 0389-1121 67.2 µM 0.684153610706818 0.233512884022577 no 803 0.246939085872945 1270 6753108 SGTC_233 rapamycin 362 pM 0.683449604328864 0.233741529906398 no 804 0.247161392260009 1231 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C SGTC_565 1418-0001 44.5 µM 0.683183498834057 0.233827987462606 no 805 0.247245449125301 1244 2862145 SGTC_735 3076-0345 636 µM 0.681915919856499 0.234240066481012 no 806 0.247646059139695 1245 2888990 SGTC_76 0433-0009 400.328 µM 0.681004863015674 0.234536491359094 no 807 0.247934206669406 1198 2841569 SGTC_440 fluspirilene 35.1 µM 0.679490280568212 0.235029740489917 no 808 0.24841363197362 1279 3396 An atypical antipsychotic. SGTC_152 4469-0003 551.229 µM 0.679434688866197 0.235047855755184 no 809 0.248431238343797 1205 697280 SGTC_364 0083-0097 67.7 µM 0.679377695813183 0.235066428469265 no 810 0.248449289224267 1249 5207356 SGTC_2737 bleomycin 30.5 nM 0.678942332268135 0.235208330096375 no 811 0.248587200937053 1243 16211318 Bleomycin acts by induction of DNA strand breaks. SGTC_993 3909-8757 62.7 µM 0.677401592597764 0.235710895781055 no 812 0.249075594075744 1193 4288324 YLR208W SEC13 SGTC_712 r015-0009 80.6 µM 0.677337455615584 0.235731829113245 no 813 0.249095935672143 1185 6813872 YLR060W FRS1 SGTC_2318 6029776 164 µM 0.675703596718179 0.236265441283154 no 814 0.249614425968629 1240 818325 SGTC_1907 st060210 83.7 µM 0.675699446110415 0.236266797702533 no 815 0.249615743855984 1248 688793 SGTC_1689 st020265 53.493 µM 0.675135227647425 0.236451224306637 no 816 0.249794927046341 1228 5758320 YPR016C TIF6 SGTC_192 3455-0609 60.9 µM 0.675045035591218 0.236480712810176 no 817 0.249823576359755 1272 3769639 SGTC_3260 9137109 49.47 µM 0.674974118998178 0.236503900577313 no 818 0.249846104088577 1113 17478346 SGTC_477 mead ethanolamide 10 µM 0.674664236899885 0.236605238142281 no 819 0.249944555476251 1113 16061185 SGTC_2401 5128683 200 µM 0.674490759476595 0.236661979113892 no 820 0.249999679274407 1183 708373 SGTC_988 1497-1057 103 µM 0.674390079163749 0.236694913049139 no 821 0.250031674183668 1236 3533044 SGTC_1511 0906-3109 28.5 µM 0.672190971496649 0.237414900397701 no 822 0.250731063984715 1278 2882180 SGTC_3114 9122766 49.47 µM 0.67164983634469 0.237592252084524 no 823 0.250903321753715 1180 17176985 SGTC_1218 1348-1416 30.7 µM 0.671285302559403 0.237711765394248 no 824 0.251019397893344 1233 6787668 SGTC_2797 7859098 81.82 µM 0.670065689497294 0.238111858221873 no 825 0.251407957873677 1259 972681 SGTC_2479 5617353 43.85 µM 0.669234234502242 0.238384827595194 no 826 0.251673035599311 1275 2731746 SGTC_1186 1319-0216 26 µM 0.667846405465441 0.23884083786039 no 827 0.252115820589975 1292 4565136 SGTC_415 dibenzyl ketone 100 µM 0.666291967729237 0.239352158057896 no 828 0.252612249323691 1246 7593 SGTC_2784 7567673 72.73 µM 0.665363223558942 0.239657946338851 no 829 0.252909100692644 1265 3471247 SGTC_1245 0418-0076 17.2 µM 0.664777395059652 0.239850939515113 no 830 0.253096441467538 1244 6790114 SGTC_2795 7780010 54.55 µM 0.66416366055441 0.240053216840719 no 831 0.253292784510705 1233 953673 SGTC_1785 bathophenanthroline 24 µM 0.664003921414332 0.240105879620782 no 832 0.253343900632154 1209 72812 An iron chelator. SGTC_2320 7373003 200 µM 0.663420430716342 0.240298298269446 no 833 0.253530662251795 1244 5415828 SGTC_598 3937-0236 20.2 µM 0.661907212847501 0.240797705758385 no 834 0.254015344464318 1271 1379313 SGTC_2107 5363541 170.161 µM 0.661807539919596 0.240830620640602 no 835 0.254047286662983 1230 244052 SGTC_3097 9117246 49.47 µM 0.660794517364816 0.241165288800133 no 836 0.2543720496634 1266 16423892 SGTC_2874 9043904 71.43 µM 0.660791394747391 0.241166320797295 no 837 0.254373051073763 1210 4463428 SGTC_2013 4024628 200 µM 0.659491603832087 0.24159609847748 no 838 0.254790067963385 1280 5230760 SGTC_3146 9095609 49.47 µM 0.656933615099166 0.242443114144249 no 839 0.25561180132935 1295 17173999 SGTC_3164 9100705 49.47 µM 0.656897103830442 0.242455215595215 no 840 0.255623540292786 1264 17174235 SGTC_528 3492-0019 172 µM 0.656036920031008 0.242740413231759 no 841 0.255900184731545 1296 2869262 SGTC_3162 9099653 49.47 µM 0.655901668178983 0.242785273079979 no 842 0.255943697404151 1237 25237511 SGTC_656 4090-1979 187 µM 0.655367122501641 0.242962613171211 no 843 0.25611570702574 1275 22330961 SGTC_3315 9136395 68.55 µM 0.655291661675926 0.242987653587487 no 844 0.256139994161498 1305 16876844 SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM 0.654020255594159 0.243409758317527 no 845 0.256549377892676 1102 4000243 SGTC_2860 9025725 38.96 µM 0.653463661999631 0.243594671087196 no 846 0.256728704277762 1222 40546248 SGTC_159 3970-0959 50 µM 0.652772750516082 0.243824312738426 no 847 0.256951396684257 1337 6615653 SGTC_2349 9023730 187.07 µM 0.652591497580089 0.243884576009881 no 848 0.257009834194402 1274 4126287 SGTC_1555 citronellol 128 µM 0.651347813329651 0.244298294873139 no 849 0.257410995111781 1249 8842 A terpine precursor. SGTC_1576 erythromycin ethylsuccinate 23.2 µM 0.6499847774475 0.244752150895791 no 850 0.257851027293889 1281 3256 An antibiotic and ribosome inhibitor. SGTC_296 1222-0039 74.9 µM 0.64951391783617 0.244909040504615 no 851 0.258003126706675 1228 5984176 SGTC_443 clozapine 122 µM 0.64928793578653 0.244984356548041 no 852 0.258076141075386 1191 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_1578 josamycin 24.2 µM 0.649133146385954 0.245035952460557 no 853 0.258126159417977 1189 5282165 A P450 substrate. SGTC_2699 st077704 54.6 µM 0.647891469523635 0.245450051739276 no 854 0.258527574245887 1275 645852 SGTC_3043 9092303 49.47 µM 0.646511010576364 0.245910875908849 no 855 0.258974234385534 1222 25236084 SGTC_1498 4478-3555 97.6 µM 0.64585201813746 0.246131024078007 no 856 0.259187598090025 1239 3437919 SGTC_2725 haloperidol 53.21 µM 0.645155702515117 0.246363755525547 no 857 0.259413144709558 1229 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_2556 citropten 84.59 µM 0.644351954379103 0.24663254101562 no 858 0.259673616263642 1266 2775 A potential DNA crosslinker. SGTC_2700 st077718 96.8 µM 0.643865144836695 0.24679541380427 no 859 0.259831442792684 1265 904970 SGTC_1509 1326-1131 80 µM 0.643756235891411 0.246831859556521 no 860 0.259866758489452 1239 768313 SGTC_3254 9136651 49.47 µM 0.642312359604137 0.24731531663061 no 861 0.260335195434663 1256 16454030 SGTC_480 am 92016 50 µM 0.639961591480001 0.248103512539701 no 862 0.261098785006782 1215 2129 K+ channel blocker. SGTC_3023 9089636 49.47 µM 0.638249984732483 0.248678244070311 no 863 0.261655482012839 1343 17249241 SGTC_2075 5212009 200 µM 0.636850434210634 0.249148718276611 no 864 0.262111135530856 1248 780898 SGTC_1999 st074831 12.5 µM 0.636127936963566 0.249391778780273 no 865 0.262346518965644 1277 17112523 SGTC_1850 st056238 17 µM 0.635850946666157 0.24948499649305 no 866 0.262436788738046 1279 5393177 SGTC_2408 sulbentine 18.36 µM 0.634408904560402 0.2499705971704 no 867 0.262906999921775 1328 67686 An antifungal agent of unknown mechanism. YDL205C HEM3 SGTC_2518 prenyletin 46.28 µM 0.630779233412653 0.251195088024938 no 868 0.264092441755711 1236 3873459 A coumarin with calcium channel inhibitory activity. SGTC_2454 5-benzylidenerhodanine 10.36 µM 0.628554839474558 0.251947065121568 no 869 0.264820266893575 1325 1273210 SGTC_1968 st069590 43.6 µM 0.628440567801565 0.251985727782942 no 870 0.264857684280764 1246 6384066 SGTC_2820 7989630 71.43 µM 0.628096611369413 0.252102120844243 no 871 0.264970326405141 1209 2984098 SGTC_2718 lomofungin 53.02 µM 0.626721890380578 0.252567602298752 no 872 0.265420776055685 1344 5351222 A RNA synthesis inhibitor. SGTC_1065 prochlorperazine maleate 2.48 µM 0.625747325304465 0.252897864755857 no 873 0.265740343340711 1341 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine. SGTC_435 c-PAF 6.7 µM 0.624139356455729 0.253443272785351 no 874 0.266268034606265 1269 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase SGTC_3089 9117425 49.47 µM 0.623862388907119 0.253537279960551 no 875 0.266358981274065 1232 9401657 SGTC_3204 9114183 49.47 µM 0.623575186058385 0.253634780502899 no 876 0.266453305462122 1323 17027248 SGTC_2273 7815444 169.05 µM 0.622821376104525 0.253890779966264 no 877 0.266700954776173 1302 2824616 SGTC_2046 4110841 106 µM 0.620922054416056 0.254536404561118 no 878 0.267325454729505 1325 44119630 YMR134W ERG29 SGTC_1227 3909-8010 46.6 µM 0.620755609495226 0.254593024108469 no 879 0.267380217220425 1316 15982272 SGTC_3011 9081274 71.4286 µM 0.619897571718549 0.254885007338632 no 880 0.267662612286962 1304 6625322 SGTC_212 3807-4682 38.772 µM 0.619690885946047 0.254955366998404 no 881 0.267730658607342 1389 3125501 YBL034C STU1 SGTC_2607 solasodine 47.35 µM 0.618864012153123 0.255236951757975 no 882 0.26800297408672 1321 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity. SGTC_606 k015-0008 38.6 µM 0.616018019121733 0.256207371746401 no 883 0.268941313643338 1390 1970475 SGTC_468 gf-109203x 121 µM 0.615199033174721 0.25648698365906 no 884 0.269211643105593 1256 2396 A protein kinase C inhibitor. SGTC_306 1672-3436 11.6 µM 0.614819819301928 0.256616505783041 no 885 0.269336859515544 1343 6797378 SGTC_908 3448-7491 47.7 µM 0.611117605764101 0.257882799981429 no 886 0.270560862574504 1326 1203031 SGTC_3193 9111931 49.47 µM 0.611080704943057 0.257895437728733 no 887 0.270573076468786 1367 17087244 SGTC_1117 retinoic acid 1.10837 µM 0.610486822548568 0.258098874025912 no 888 0.270769684953738 1363 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR). SGTC_634 1611-4317 11.2 µM 0.60860952272348 0.258742495885738 no 889 0.271391645491919 1344 2843522 SGTC_1321 1326-2144 215 µM 0.608485862948425 0.258784921099088 no 890 0.271432639682529 1309 3513030 SGTC_2760 etidronate 98.04 µM 0.6084611174616 0.258793411216512 no 891 0.271440843376972 1303 3305 A chelator and antioxidant. SGTC_724 3910-0327 137 µM 0.608017484094779 0.258945645218296 no 892 0.271587938931886 1307 2885483 SGTC_402 epigallocatechin gallate 10 µM 0.606763619969499 0.259376162462218 no 893 0.272003897286597 1319 65064 An antioxidant. SGTC_272 doxorubicin 8.13 µM 0.606127413906827 0.259594746662803 no 894 0.272215074125684 1327 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_3119 9125183 49.47 µM 0.604358936657194 0.260202849639523 no 895 0.272802515162404 1218 22695334 SGTC_74 000s-0487 160.283 µM 0.60410623540176 0.260289802599761 no 896 0.272886507110526 1263 677548 SGTC_2551 apiole 73.87 µM 0.602359138775166 0.260891377196506 no 897 0.273467551506591 1261 10659 A possible DNA adduct former. SGTC_1562 morin hydrate 59.1 µM 0.601917489779052 0.261043562545506 no 898 0.273614530786966 1356 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase. SGTC_1491 4138-0063 26.5 µM 0.599720769933375 0.261801195381779 no 899 0.274346171871766 1317 23883227 SGTC_2461 5755302 26.15 µM 0.598833233123377 0.262107620036012 no 900 0.274642049212794 1410 2788904 SGTC_597 k018-0003 82.8 µM 0.597541147338128 0.262554044738519 no 901 0.275073071821118 1439 6786234 SGTC_2490 carminic acid 95.39 µM 0.596842330730945 0.26279565283049 no 902 0.275306326479321 1301 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_2947 9072639 7.68 µM 0.596602391706729 0.262878635303597 no 903 0.275386437025042 1317 16488146 SGTC_785 1270-0111 65.3 µM 0.594523448784643 0.263598194452415 no 904 0.276081031778934 1324 6741994 SGTC_1972 st070201 17.4 µM 0.59451189980161 0.263602194566037 no 905 0.276084892805965 1356 2829099 SGTC_2957 9076800 11.52 µM 0.593991281126252 0.263782548566049 no 906 0.276258972263552 1305 16459615 SGTC_2290 7904846 200 µM 0.593770768234095 0.263858958150081 no 907 0.276332721474103 1354 2962154 SGTC_2400 5203494 178.7 µM 0.593289948446275 0.264025605395911 no 908 0.276493562241922 1310 6777674 SGTC_2747 doxorubicin 7.63 µM 0.592999222132415 0.264126394190267 no 909 0.276590836416891 1267 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_1496 4469-0713 57.4 µM 0.591613725511498 0.264606986310524 no 910 0.277054640329521 1369 746691 SGTC_3080 9117754 49.47 µM 0.591523778574219 0.26463820189295 no 911 0.277084763798947 1466 9550191 SGTC_511 blebbistatin 171 µM 0.591446710432109 0.264664949451316 no 912 0.277110575400472 1411 3476986 A myosin inhibitor. SGTC_611 3453-1652 23.7 µM 0.590862803095485 0.264867647183773 no 913 0.277306175405715 1380 1560575 SGTC_1366 1683-0113 21.9 µM 0.590076935129974 0.265140578086697 no 914 0.277569535667729 1348 708623 SGTC_149 3970-0822 46.1 µM 0.588274562515084 0.265767078699543 no 915 0.278174008388578 1419 3114250 YBL034C STU1 SGTC_2805 7950783 58.44 µM 0.58693532295548 0.26623308078488 no 916 0.278623572680044 1389 1178958 YDL195W SEC31 SGTC_758 0868-0029 16 µM 0.586326043973152 0.266445222437788 no 917 0.278828216282007 1362 762687 SGTC_1430 4049-0248 69.1 µM 0.585043676908094 0.266892002324863 no 918 0.279259174422086 1435 22774488 SGTC_1816 st051957 91.6 µM 0.584381946849336 0.267122698679887 no 919 0.279481684996326 1375 674121 SGTC_704 1310-0270 142 µM 0.583811879471813 0.267321519720689 no 920 0.279673442470056 1320 5718033 SGTC_2128 5255449 168.493 µM 0.583161249521434 0.267548529577787 no 921 0.27989237732459 1330 736008 SGTC_1663 st014140 55.4 µM 0.58188813755761 0.267993009244065 no 922 0.280321015633398 1437 4207120 SGTC_744 1594-0068 283 µM 0.580489312843044 0.268481807119908 no 923 0.280792345837703 1382 668392 SGTC_2834 9001755 58.44 µM 0.578324123793723 0.269239282066164 no 924 0.281522655195186 1398 2989575 SGTC_261 5-fluorouridine 15.376 µM 0.577544855551657 0.269512165228604 no 925 0.281785723218079 1410 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_2286 7945697 125 µM 0.576884201575942 0.26974362071683 no 926 0.282008841795042 1330 1245733 SGTC_1602 st001878 87.6 µM 0.57672247209101 0.269800296671644 no 927 0.282063474654034 1401 595405 YLR310C CDC25 SGTC_557 1315-0110 16.2 µM 0.576343028540398 0.269933291036922 no 928 0.282191672186367 1350 6833801 SGTC_446 go6976 132 µM 0.576112578497484 0.270014079425771 no 929 0.2822695449555 1358 3501 A protein kinase C inhibitor. SGTC_2055 5235184 200 µM 0.576057516939807 0.270033384031333 no 930 0.282288152670235 1386 2836034 SGTC_3339 9145883 14.936 µM 0.575454216763278 0.270244946556193 no 931 0.282492072907911 1347 2030670 SGTC_2866 9034245 58.44 µM 0.573772459079631 0.270835134793158 no 932 0.283060893971561 1374 6462273 SGTC_1702 st027038 51 µM 0.573535839971866 0.270918224400221 no 933 0.283140969767204 1393 5521182 SGTC_2531 methyl deoxycholate 70.07 µM 0.57260241711338 0.271246123032183 no 934 0.283456961373877 1347 16667744 Haematoxylin. SGTC_1882 5615643 20 µM 0.57176676371465 0.271539844334112 no 935 0.283739998415092 1321 2253075 SGTC_478 N-arachidonylglycine 10 µM 0.57173187848395 0.271552109482546 no 936 0.283751817036514 1350 5283389 SGTC_1174 0739-0097 51.1 µM 0.571701880413538 0.27156265659591 no 937 0.283761980145843 1395 728447 SGTC_776 4476-4378 112 µM 0.57071893247871 0.271908367086573 no 938 0.284095091532533 1382 2892008 SGTC_1296 1068-0102 11.9 µM 0.569906283012847 0.27219434749985 no 939 0.284370631604065 1391 767053 SGTC_2693 st077581 40.7 µM 0.565460013590092 0.273761680895098 no 940 0.285880457347869 1388 25238761 SGTC_2880 9042983 58.44 µM 0.564654767909391 0.274046010895934 no 941 0.286154302811315 1390 6464714 SGTC_2878 9043973 25.97 µM 0.561665623948373 0.27510274377585 no 942 0.28717192992215 1458 6465167 SGTC_1645 Cervolide 78 µM 0.561416391090035 0.275190944024889 no 943 0.287256856317727 1342 23173 A fragrance. SGTC_2917 7979103 53.79 µM 0.561075852135074 0.275311478810702 no 944 0.287372914586639 1466 2980565 SGTC_2899 9053889 58.44 µM 0.560882322017936 0.275379990954292 no 945 0.287438881007791 1384 6470052 SGTC_2802 7925815 54.55 µM 0.5608438314822 0.275393618097722 no 946 0.287452001694954 1369 1262923 SGTC_2624 nerol 100 µM 0.56003982812624 0.275678342315308 no 947 0.287726135785785 1415 637566 A natural product oil. SGTC_425 3825-7017 13.1 µM 0.559370752573853 0.27591539439671 no 948 0.287954358834601 1472 3397440 SGTC_834 0312-0008 75.7 µM 0.557288695505321 0.276653702871272 no 949 0.288665099034003 1407 6385573 YIL048W NEO1 SGTC_567 1080-0542 68.4 µM 0.556855199111577 0.276807544677169 no 950 0.288813183134861 1378 5950415 SGTC_2642 cholecalciferol 100 µM 0.556059426678423 0.277090062200759 no 951 0.289085115216433 1425 9821465 A vitamin D precursor, similar to steriods. SGTC_253 dyclonine 31.25 µM 0.55601159955386 0.277107046424735 no 952 0.289101462580396 1449 3180 An oral anasthetic. SGTC_2412 st077135 33.4 µM 0.555869100091441 0.277157653423244 no 953 0.289150171631014 1483 13258915 SGTC_343 4130-2827 29.8 µM 0.555071663816799 0.277440936911925 no 954 0.289422821843559 1390 1118244 SGTC_317 4495-0002 170 µM 0.555014824642424 0.277461134021447 no 955 0.289442260248453 1365 15991618 SGTC_2037 5169046 200 µM 0.552417072607515 0.278384979854242 no 956 0.290331318131793 1430 5718022 SGTC_1530 rhein 70.4 µM 0.550758408326136 0.278975638406887 no 957 0.29089964957596 1435 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death. SGTC_464 bw-b 70c 158 µM 0.550052723640601 0.279227120928221 no 958 0.291141605801954 1450 5353454 SGTC_537 1334-0398 209 µM 0.549004119619791 0.279601011859437 no 959 0.291501311339798 1464 5846986 SGTC_1606 st000094 49.2 µM 0.548430781320362 0.279805544451831 no 960 0.291698072769848 1454 1242210 SGTC_1528 arabinosylhypoxanthine 74.6 µM 0.546636199320259 0.28044621201816 no 961 0.29231434716813 1447 804 An inhibitor of viral and cellular DNA polymerases. SGTC_2685 mycophenolic acid 18.85 µM 0.546291049135016 0.280569512354383 no 962 0.292432944010127 1436 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_1733 st037357 54.9 µM 0.54540654327003 0.280885610066314 no 963 0.292736970590851 1346 1272339 YGL099W LSG1 SGTC_3105 9121040 49.47 µM 0.543798459692904 0.281460734874055 no 964 0.293290084449447 1312 41448907 SGTC_577 r071-0003 38.6 µM 0.54264324700546 0.281874242563708 no 965 0.293687728289664 1422 4568517 YMR134W ERG29 SGTC_1920 st075728 45.7 µM 0.537991067431163 0.283542443969821 no 966 0.295291607736083 1528 3400306 SGTC_1935 st074532 41.6 µM 0.536345256307013 0.284133737821666 no 967 0.295859979202821 1531 2829742 SGTC_919 tnp00227 403.569 nM 0.533832574511842 0.285037609805274 no 968 0.296728687255816 1459 1269246 A methoxyflavone. YNL221C POP1 SGTC_28 pentachloropyridine N-oxide 1.606 µM 0.531685857815063 0.285810919713562 no 969 0.297471794203108 1422 140250 A respiratory chain inhibitor. SGTC_3309 9129340 25.759 µM 0.531495500682375 0.285879540030159 no 970 0.297537729182397 1504 17158987 SGTC_1765 st044815 90.4 µM 0.530904547942955 0.286092617735481 no 971 0.297742463017566 1368 645695 SGTC_968 1309-0633 340 µM 0.530891727788754 0.286097241088506 no 972 0.297746905234361 1438 3761976 SGTC_3078 9116413 49.47 µM 0.530333426714199 0.286298616536524 no 973 0.297940387330331 1364 17177322 SGTC_2260 7964312 200 µM 0.529630651939852 0.28655219830871 no 974 0.298184018975478 1518 231951 SGTC_965 1291-5240 308 µM 0.52939503864042 0.286637238346953 no 975 0.298265719583001 1522 2834598 SGTC_2036 5160441 105 µM 0.528962405543254 0.286793420007213 no 976 0.298415764758592 1481 134534 YIL048W NEO1 SGTC_1685 st024049 53.0905 µM 0.528918636888795 0.28680922285052 no 977 0.298430946452271 1424 1941139 SGTC_827 3253-0474 693 µM 0.528918268311307 0.286809355928612 no 978 0.298431074299378 1509 5402065 SGTC_2303 7774051 200 µM 0.52742071421897 0.287350302265613 no 979 0.298950730970028 1509 2953184 SGTC_793 0488-0545 106 µM 0.525432748154122 0.288069139937301 no 980 0.299641196542786 1402 292548 SGTC_3072 9116419 49.47 µM 0.525101307393236 0.288189069598344 no 981 0.299756383650721 1394 17170162 SGTC_3150 9097574 49.47 µM 0.52490828455909 0.288258924493549 no 982 0.299823474988492 1517 17217476 SGTC_1160 4092-0570 10.5 µM 0.524569249894079 0.288381640346906 no 983 0.29994133392255 1417 4994975 SGTC_2245 6637752 200 µM 0.523994091009724 0.288589879245925 no 984 0.300141324878456 1533 681890 SGTC_3167 9103034 49.47 µM 0.523965178394939 0.288600349059795 no 985 0.300151379799147 1455 5127859 SGTC_1938 st074717 56.4 µM 0.52388216765751 0.28863040983863 no 986 0.300180249234206 1366 17250979 SGTC_1616 st002734 56.1 µM 0.523149419992249 0.288895824586028 no 987 0.300435138309247 1460 4026101 SGTC_1413 3910-0535 34.4 µM 0.52304854450058 0.288932372546337 no 988 0.300470235889678 1512 2876951 SGTC_2861 9024595 19.48 µM 0.522399255307676 0.289167667028679 no 989 0.300696187199188 1427 16482810 SGTC_1444 4112-3581 28 µM 0.521651900906034 0.289438610622805 no 990 0.300956359889396 1465 2877249 SGTC_3125 9127534 49.47 µM 0.519476412242083 0.290227983705097 no 991 0.301714278793955 1397 1639235 SGTC_2988 9073640 71.4286 µM 0.518990720680639 0.290404353838649 no 992 0.301883606086875 1500 9102229 SGTC_1673 st016611 27.3 µM 0.518623472938054 0.290537746541225 no 993 0.302011668497624 1536 5226799 SGTC_3299 9121982 43.1275 µM 0.518328209119711 0.29064501384011 no 994 0.302114647192548 1456 17594604 YPL160W CDC60 SGTC_2610 ononetin 44.17 µM 0.517739308734764 0.290859012573013 no 995 0.302320084109255 1427 259632 SGTC_2756 carbadox 75.1 µM 0.516185006170304 0.291424179325112 no 996 0.302862600701276 1436 2553 A substituted quinoxaline antibiotic. YLR208W SEC13 SGTC_635 k038-0028 24.7 µM 0.516115068033655 0.291449621877336 no 997 0.302887022280244 1509 4035102 SGTC_579 4491-1009 110 µM 0.515977236116424 0.291499766305564 no 998 0.302935154153456 1559 1271041 SGTC_1351 1496-0003 46.5 µM 0.515934094630633 0.291515462373211 no 999 0.302950220166632 1494 3891978 SGTC_3343 9148379 18.9835 µM 0.513736182584993 0.292315644720202 no 1000 0.303718225615053 1587 1955036 SGTC_2576 guaiol 23.12 µM 0.511784447863491 0.29302705770491 no 1001 0.304400937980102 1540 227829 SGTC_2296 7971656 126.45 µM 0.510853445464647 0.293366693505609 no 1002 0.304726840970435 1456 666570 SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM 0.510041186335751 0.293663159889093 no 1003 0.305011303810122 1482 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding. SGTC_2204 7233102 200 µM 0.508241421198085 0.294320549570118 no 1004 0.305642022779242 1473 2172480 SGTC_3324 9138759 60.749 µM 0.506521649564049 0.294949354720766 no 1005 0.306245247714509 1486 45595710 SGTC_1010 4112-3296 15.2 µM 0.506068357154779 0.29511519637957 no 1006 0.306404331586117 1577 704384 SGTC_1668 st014914 51.6 µM 0.504386449283229 0.295730914487951 no 1007 0.30699491924926 1475 2839556 SGTC_2133 5320837 200 µM 0.504048312592815 0.295854771857852 no 1008 0.30711371362967 1529 2841355 SGTC_829 1635-0120 117 µM 0.501532810245271 0.296776931724589 no 1009 0.307998096339505 1584 285054 SGTC_1832 st054113 55 µM 0.500904666905577 0.297007408402303 no 1010 0.308219108943353 1489 1251267 SGTC_694 1315-0438 43.2 µM 0.500453326461837 0.297173063563642 no 1011 0.308377956288954 1513 6793154 SGTC_2304 7443016 91.4 µM 0.498837262202898 0.297766552542933 no 1012 0.308947017313736 1455 939854 SGTC_1305 1181-0477 144 µM 0.49857402964922 0.297863274151685 no 1013 0.309039752287459 1569 6252086 SGTC_1137 ixabepilone 100 µM 0.496784701299454 0.298521120477958 no 1014 0.309670442374308 1455 154225 A novel microtubule stabilizer. SGTC_2900 5328528 85.29 µM 0.49625198931075 0.298717099569466 no 1015 0.309858317429809 1436 795359 SGTC_383 2324-0395 7.37 µM 0.495691409396851 0.29892339410889 no 1016 0.310056074488707 1547 3146421 SGTC_880 0833-0487 87.2 µM 0.49507878385873 0.299148915520471 no 1017 0.3102722546499 1464 76075 SGTC_2052 5265182 7.135 µM 0.495014792827974 0.299172476529938 no 1018 0.310294839260659 1582 1239884 SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM 0.493929790849278 0.299572094112082 no 1019 0.310677882199861 1491 442882 SGTC_1254 0550-0035 264 µM 0.493614938031834 0.299688102966255 no 1020 0.310789074504123 1583 15121435 SGTC_2716 st080858 38.6235 µM 0.492448137860404 0.300118192764872 no 1021 0.311201288144712 1493 5296050 SGTC_1909 st060837 51.5 µM 0.491797279542204 0.30035822441365 no 1022 0.311431329950007 1449 678937 SGTC_2140 5586273 200 µM 0.491554752222121 0.300447688843574 no 1023 0.311517068553797 1480 854421 SGTC_2506 ethyl hematommate 54.16 µM 0.491364348267298 0.300517934235665 no 1024 0.311584387594146 1431 3940691 An allergen. SGTC_1939 st074455 53.6 µM 0.491284742500658 0.30054730524801 no 1025 0.311612534800201 1603 1644229 SGTC_3133 9127736 49.47 µM 0.490468355326592 0.300848590842126 no 1026 0.311901258528381 1548 27243420 SGTC_1508 1080-0625 72.9 µM 0.487631392924846 0.30189662216849 no 1027 0.312905477628707 1484 767111 SGTC_3111 9122088 49.47 µM 0.487546337189305 0.301928068793075 no 1028 0.312935606888019 1499 16876704 SGTC_1291 0993-0025 5.79 µM 0.485968977222904 0.302511513435854 no 1029 0.313494580742672 1594 4353356 SGTC_398 bronopol 33.3 µM 0.485281041868632 0.302766129836159 no 1030 0.313738500790433 1532 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them. SGTC_2973 9094665 17.96 µM 0.485048809898172 0.302852104443671 no 1031 0.313820861270186 1615 25237061 YIL048W NEO1 SGTC_51 1013-0126 23.419 µM 0.484722428163525 0.302972952711759 no 1032 0.313936627406879 1612 1627850 SGTC_691 1548-0686 185 µM 0.484170455425837 0.303177378896813 no 1033 0.314132451336337 1465 46495133 SGTC_2218 6965428 192.983 µM 0.482403603127887 0.303832156827475 no 1034 0.314759631016262 1560 675684 SGTC_2488 5268135 45.7 µM 0.47924759814303 0.30500330777053 no 1035 0.315881248136255 1588 1270356 YLR208W SEC13 SGTC_1195 1502-0147 41.1 µM 0.47699084416362 0.305841986143261 no 1036 0.316684320700097 1479 817940 SGTC_1587 estradiol valerate 56.1 µM 0.476456714046195 0.30604063445508 no 1037 0.316874519178804 1557 13791 A steroid. SGTC_196 k015-0023 18.111 µM 0.474432034042871 0.306794150794027 no 1038 0.317595926994299 1510 5211998 SGTC_966 1300-0360 30.2 µM 0.473830785034547 0.30701807252131 no 1039 0.317810289885134 1524 70588 SGTC_2200 6600604 21.907 µM 0.473596103811011 0.307105493828152 no 1040 0.31789397719479 1474 2904777 SGTC_2093 5331342 194.4 µM 0.472424190403644 0.307542208336763 no 1041 0.318312020574207 1576 33839 SGTC_973 1325-0077 65.9 µM 0.471628676597711 0.307838812777547 no 1042 0.318595927134793 1640 2835149 SGTC_465 cgp-37157 41 µM 0.470939858295869 0.308095737664629 no 1043 0.31884184178969 1556 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange. SGTC_1216 1165-0504 9.65 µM 0.467839141987342 0.309253448727613 no 1044 0.319949813499239 1598 6304004 SGTC_1665 st014639 11.4 µM 0.46778296268297 0.3092744418573 no 1045 0.319969902778764 1596 981133 YIL048W NEO1 SGTC_3058 9093861 49.47 µM 0.467439920749669 0.30940264356209 no 1046 0.320092583341587 1550 17217477 SGTC_847 0342-0274 5.54 µM 0.46720572794194 0.309490179476499 no 1047 0.320176347975998 1626 18097 SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM 0.467061578252948 0.309544064707802 no 1048 0.320227911102159 1558 4213774 SGTC_748 act1.228 77.9 µM 0.464922289705609 0.310344242381974 no 1049 0.320993553850118 1457 4421505 YNR035C ARC35 SGTC_2954 9074818 52.69 µM 0.464665041233809 0.310440523976874 no 1050 0.321085673412376 1572 16648742 SGTC_626 0214-0009 33 µM 0.463653714118847 0.310819163996303 no 1051 0.321447931965472 1625 3437874 SGTC_1751 st044839 27.194 µM 0.463467788529072 0.31088879620182 no 1052 0.321514549226548 1557 5291326 SGTC_517 1365-0151 113 µM 0.46201557523151 0.311432906948409 no 1053 0.32203507559645 1555 768657 SGTC_2520 obtusaquinone 4.71 µM 0.461383471351378 0.311669870467954 no 1054 0.322261753929322 1631 5967872 SGTC_378 3970-0959 8.33 µM 0.460771566674392 0.311899336010285 no 1055 0.322481251623827 1550 6615653 SGTC_520 3584-0023 682 µM 0.46068047226105 0.311933502854361 no 1056 0.322513933599129 1507 1340790 SGTC_1641 st009299 47.1 µM 0.45905960669358 0.312541712366991 no 1057 0.323095681236145 1531 4046054 SGTC_3175 9106517 49.47 µM 0.458788007603086 0.312643676548976 no 1058 0.323193203722527 1512 41468073 SGTC_411 enrofloxacin 100 µM 0.457776401653918 0.31302358146928 no 1059 0.323556545722461 1707 71188 A bacterial gyrase inhibitor. SGTC_3017 9080681 49.47 µM 0.455918247292854 0.313721921799346 no 1060 0.324224383709062 1517 16451914 SGTC_1368 1852-0141 284 µM 0.455810043200583 0.313762608175611 no 1061 0.324263290725052 1532 2838987 SGTC_2121 5257820 149.641 µM 0.455383897033756 0.313922867605752 no 1062 0.324416539037538 1627 791256 SGTC_2832 7992762 51.95 µM 0.454624720479178 0.314208455675971 no 1063 0.324689623559721 1391 2985177 SGTC_2765 myclobutanil 7.74 µM 0.454372445353983 0.314303381515607 no 1064 0.324780390692145 1546 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11 SGTC_904 1141-0088 396 µM 0.452982470546347 0.314826620016672 no 1065 0.32528068207125 1454 1378119 SGTC_1502 4534-4282 27.7 µM 0.452397236580223 0.315047035302535 no 1066 0.325491418692459 1559 3278949 SGTC_3197 9113331 49.47 µM 0.451802700495293 0.315271021481281 no 1067 0.325705562048018 1648 16610459 YLR208W | YDL195W SEC13 | SEC31 SGTC_3190 9110366 49.47 µM 0.451047357815651 0.315555688067283 no 1068 0.325977708594758 1650 17123768 SGTC_1004 4084-0029 199 µM 0.450538266471686 0.315747611495696 no 1069 0.326161184221907 1659 716894 YLR208W SEC13 SGTC_3024 9090631 49.47 µM 0.450346049266989 0.315820088794614 no 1070 0.326230469912772 1606 25236383 SGTC_2648 atorvastatin 78.68 µM 0.449853206921029 0.316005951973805 no 1071 0.3264081448986 1626 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11 SGTC_2986 9022445 71.43 µM 0.449843977660383 0.316009433002752 no 1072 0.326411472522583 1659 6459286 SGTC_418 lividomycin a 100 µM 0.449377770341202 0.316185295086995 no 1073 0.326579582251868 1612 72394 An antibiotic. SGTC_1707 st032323 6.317 µM 0.448410244199098 0.316550396658277 no 1074 0.32692857493808 1559 3132057 YMR211W DML1 SGTC_2930 9013230 14.89 µM 0.447235993063951 0.316993747310069 no 1075 0.3273523380241 1659 2995857 SGTC_2118 5526350 200 µM 0.446408501592986 0.317306333206955 no 1076 0.327651096413287 1598 743594 SGTC_1073 triclabendazole 3.09 µM 0.446275272485174 0.317356672851872 no 1077 0.32769920791106 1586 50248 An antihelmetic and likely tubulin inhibitor. SGTC_2191 5911152 200 µM 0.444302680430149 0.318102397269582 no 1078 0.328411881788856 1572 2875902 SGTC_1479 0549-0158 134 µM 0.444229492860411 0.318130079527398 no 1079 0.3284383356171 1564 5440202 SGTC_3073 9114972 49.47 µM 0.444177771595884 0.318149643043794 no 1080 0.328457030914875 1664 41905075 SGTC_532 1548-0774 215 µM 0.442580650784524 0.318754001882419 no 1081 0.329034541408635 1668 5932993 SGTC_2574 2',4'-dihydroxychalcone 14.64 µM 0.442140562169543 0.318920618546266 no 1082 0.329193746954962 1692 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_177 1327-0068 8.361 µM 0.442111729865465 0.318931535676384 no 1083 0.329204178351227 1526 15389900 YOR207C | YLR033W RET1 | RSC58 SGTC_3209 9113616 49.47 µM 0.441925462174339 0.319002068289923 no 1084 0.329271572357393 1761 16649353 SGTC_2571 chrysanthemic acid 100 µM 0.441418763428944 0.319193969328048 no 1085 0.329454930438265 1494 2743 An insecticide. SGTC_1955 wogonin 32.4 µM 0.440988437069958 0.319356984054213 no 1086 0.329610684003372 1658 5281703 A flavanone. SGTC_1998 st075797 76.8 µM 0.440957672373247 0.319368639566999 no 1087 0.329621820199006 1639 24208315 SGTC_1177 0983-0204 23.6 µM 0.4401689888187 0.319667501127084 no 1088 0.329907359189984 1681 766818 SGTC_2573 2',4'-dihydroxychalcone 15.04 µM 0.437921375797758 0.320519847433341 no 1089 0.330721639781243 1639 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_957 1187-1561 14.1 µM 0.435029750213333 0.321617811284865 no 1090 0.331770416605855 1558 1538454 SGTC_1373 2887-0003 58.5 µM 0.435015988453011 0.321623040427131 no 1091 0.33177541108321 1562 776948 SGTC_958 1222-0007 33 µM 0.43477256035725 0.321715543166004 no 1092 0.331863761998112 1658 7312461 SGTC_1037 k284-1091 78.7 µM 0.433673530079256 0.322133312481895 no 1093 0.332262765464275 1555 3334711 SGTC_801 0866-0028 10.1 µM 0.433363781917333 0.322251096258642 no 1094 0.332375254059128 1590 6849771 SGTC_1924 st058459 75.1 µM 0.432357827965091 0.322633739938665 no 1095 0.332740681876939 1564 688683 SGTC_1894 3',6'-dihydroxyflavone 78.7 µM 0.432184271277221 0.322699776262768 no 1096 0.332803745027416 1637 688662 SGTC_676 falcarinol 140 µM 0.43111355113037 0.323107296569973 no 1097 0.333192903938571 1694 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer. SGTC_1420 4'-methoxyflavone 42 µM 0.430551852660434 0.323321166196771 no 1098 0.333397128100412 1667 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13 SGTC_780 0109-0199 192 µM 0.429334974310224 0.323784699214659 no 1099 0.333839734052861 1718 610414 SGTC_304 1310-0298 97 µM 0.426817530714766 0.324744510680878 no 1100 0.33475611836507 1544 1550234 SGTC_2173 5763948 167 µM 0.426736095358416 0.324775578560801 no 1101 0.334785778437372 1594 2867177 SGTC_1384 3089-0840 101 µM 0.42485663645503 0.325492937186695 no 1102 0.335470593808503 1694 1069836 SGTC_3307 9126885 69.2785 µM 0.423574969460188 0.325982499637604 no 1103 0.33593790655968 1529 24824909 SGTC_1266 0828-0227 32.9 µM 0.423570532800875 0.325984194844326 no 1104 0.335939524665496 1641 3913820 SGTC_1194 1488-0194 225 µM 0.423178044488275 0.326134175248927 no 1105 0.336082682151836 1592 1391452 SGTC_754 3474-0146 171 µM 0.421741397468346 0.326683396703229 no 1106 0.336606892225193 1499 24762078 SGTC_1336 1486-0901 104 µM 0.421506061787653 0.326773399961724 no 1107 0.336692792850084 1622 5006114 SGTC_641 4092-0595 30 µM 0.41966084742547 0.327479444390377 no 1108 0.337366615445063 1645 786260 SGTC_2189 6047310 154.431 µM 0.419473255154511 0.327551258464253 no 1109 0.337435148353598 1575 711535 SGTC_2335 9018011 154.17 µM 0.41882978756807 0.327797639195498 no 1110 0.33767026672812 1711 6458208 SGTC_287 k060-0039 29.6 µM 0.418458686515591 0.327939766152271 no 1111 0.33780589317163 1685 5861974 SGTC_2198 6589944 200 µM 0.417276636672381 0.328392642160123 no 1112 0.338238037701879 1642 5290268 SGTC_3008 9078912 71.4286 µM 0.417026760575256 0.328488408930298 no 1113 0.338329416992973 1578 16648731 SGTC_1557 sumaresinolic acid 42.3 µM 0.416924370648157 0.328527653844429 no 1114 0.338366863577123 1542 9982268 A natural terpine and antifungal of unknown mechanisn. SGTC_1183 1254-0324 198 µM 0.416487762088396 0.32869502225029 no 1115 0.338526560300362 1670 5799357 SGTC_1630 st005209 31.3 µM 0.41614658494276 0.328825832144989 no 1116 0.338651371638137 1661 3367314 SGTC_1000 4048-0884 8.67 µM 0.415781250100886 0.328965927534797 no 1117 0.338785040128199 1632 13040088 SGTC_3255 9139072 49.47 µM 0.415501685611388 0.329073148695816 no 1118 0.338887340729099 1604 17646060 SGTC_2715 st079500 56.4 µM 0.414597926624945 0.329419862891407 no 1119 0.33921813312794 1561 28246688 SGTC_3341 9147222 25.867 µM 0.414435823339375 0.329482067021951 no 1120 0.339277479028322 1617 1939759 SGTC_1200 1643-0193 18.4 µM 0.413145348097738 0.329977431159174 no 1121 0.339750063222007 1626 5403974 SGTC_2195 6536160 144.242 µM 0.412756847934631 0.33012661998282 no 1122 0.339892385029936 1543 3834386 SGTC_2711 st079103 59.1 µM 0.412100104653544 0.330378878875923 no 1123 0.340133025988902 1714 54693780 SGTC_3132 9126706 49.47 µM 0.41143550300982 0.330634234703755 no 1124 0.340376612684494 1632 850858 SGTC_2905 7799065 20.05 µM 0.41052387289409 0.330984633021291 no 1125 0.340710847444054 1695 1296806 SGTC_3159 9100096 49.47 µM 0.409918815027722 0.331217277616468 no 1126 0.340932751426971 1539 25236875 SGTC_506 n9-isopropylolomoucine 153 µM 0.408772979851319 0.331658029443341 no 1127 0.341353135373119 1767 6610355 SGTC_1786 berberine 21.6 µM 0.408142700955328 0.331900569141737 no 1128 0.341584456050771 1549 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_2773 thioridazine 9.09 µM 0.406207686651269 0.332645628238243 no 1129 0.342295003348627 1632 5452 An antipsychotic. SGTC_1758 st042942 75.2445 µM 0.405077373821656 0.33308115086099 no 1130 0.342710318737552 1629 669317 SGTC_1158 4092-0494 91.8 µM 0.40470963910393 0.333222891891819 no 1131 0.342845478011329 1700 1148199 SGTC_583 1488-1091 88.9 µM 0.402919537209236 0.333913215322947 no 1132 0.343503709098427 1716 4303273 SGTC_868 0527-0199 213 µM 0.398745410429312 0.33552508040188 no 1133 0.345040402096112 1638 2849450 SGTC_614 0462-0418 107 µM 0.398196082851647 0.33573743304369 no 1134 0.345242826586989 1558 5188303 SGTC_2745 rifampicin 24.3 µM 0.397484569067532 0.336012559713321 no 1135 0.345505081708767 1745 25141428 Inhibits bacterial DNA-dependent RNA polymerase. SGTC_1007 4101-0031 70 µM 0.397039354291444 0.336184759148187 no 1136 0.345669220069536 1733 1146276 SGTC_1405 3909-7894 12 µM 0.396300255028251 0.336470702635902 no 1137 0.345941769559877 1718 7104060 SGTC_2221 6807166 181.081 µM 0.394636304568857 0.337114799535822 no 1138 0.346555658257969 1684 674925 SGTC_2302 7771753 200 µM 0.394462911792301 0.337181945490567 no 1139 0.346619652056126 1576 2203047 SGTC_1712 st032288 53.4 µM 0.393930278295668 0.337388239021262 no 1140 0.346816257626943 1606 2883011 SGTC_1682 st012968 530 nM 0.390255137630707 0.338812982192074 no 1141 0.348173946712717 1578 24207270 SGTC_790 1575-0012 79.1 µM 0.388299654650581 0.33957200763578 no 1142 0.348897146399951 1730 378741 YLR208W SEC13 SGTC_1921 5740136 50 µM 0.386784037901124 0.340160746059409 no 1143 0.349458047599207 1784 1774243 SGTC_1001 4048-4355 44.4 µM 0.386563450238024 0.340246465452073 no 1144 0.349539710381244 1605 21824233 SGTC_2847 9005661 71.43 µM 0.386361546996352 0.340324931398067 no 1145 0.349614462190416 1648 2991449 SGTC_489 paxilline 115 µM 0.386189731223302 0.340391709853387 no 1146 0.349678079134224 1604 105008 A toxic potassium channel blocker. SGTC_2010 4012422 159 µM 0.385821598500061 0.340534806315957 no 1147 0.349814399099651 1689 952393 SGTC_2378 9074213 121.43 µM 0.38533704791066 0.340723190432426 no 1148 0.349993858247384 1625 657714 SGTC_382 3229-0966 23.2 µM 0.383863192413121 0.341296441674457 no 1149 0.350539924219866 1734 5722370 SGTC_2975 9084847 53.72 µM 0.38136829168869 0.342267659667111 no 1150 0.351464992970687 1634 27211724 SGTC_2099 5377090 177.372 µM 0.381317207740737 0.342287556618973 no 1151 0.35148394328728 1639 2243829 SGTC_2627 acetyl isogambogic acid 100 µM 0.38076734910832 0.342501751617764 no 1152 0.351687944524835 1580 6857789 A caspase activator and apoptosis inducer. SGTC_1326 1431-2094 10.8 µM 0.380726262520307 0.342517758751441 no 1153 0.351703189640145 1608 616278 SGTC_346 4513-0042 7.16 µM 0.379804662664685 0.34287688382534 no 1154 0.352045210476008 1622 2827372 SGTC_3045 9092950 49.47 µM 0.379689703533374 0.342921690574554 no 1155 0.352087882101463 1777 44120432 SGTC_1987 st072290 61.9 µM 0.379416257475388 0.343028278448275 no 1156 0.35218938989767 1677 54697379 SGTC_2241 6772625 37.8075 µM 0.379384262695427 0.343040750666231 no 1157 0.352201267588868 1603 2285411 SGTC_1503 4585-0012 61.3 µM 0.378865174860242 0.343243125580352 no 1158 0.35239399306813 1727 2922052 SGTC_123 0083-0120 66.675 µM 0.376661624103395 0.344102715962311 no 1159 0.353212542688912 1601 16001701 SGTC_3163 9099914 49.47 µM 0.37630234689365 0.344242944148901 no 1160 0.353346067375898 1710 16268368 SGTC_1611 st001856 99.4 µM 0.376071238242548 0.344333158650425 no 1161 0.353431968006017 1617 647478 SGTC_63 0099-0242 26.702 µM 0.372868044524656 0.345584452680278 no 1162 0.354623328220825 1722 3898502 YLR359W ADE13 SGTC_3297 9117502 71.43 µM 0.372859836927521 0.345587661067236 no 1163 0.354626382696388 1680 7453720 SGTC_749 1000-0129 128 µM 0.372235749840449 0.345831652013303 no 1164 0.354858665461555 1803 708470 SGTC_1727 st034309 9.9045 µM 0.372219389132846 0.345838049201238 no 1165 0.354864755579006 1791 870305 SGTC_1863 st057641 20.1 µM 0.371948423773256 0.34594400556125 no 1166 0.354965625243784 1750 3921635 SGTC_2363 9053361 176 µM 0.371833677737033 0.345988878668877 no 1167 0.355008343710184 1782 6469797 YMR079W SEC14 SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM 0.370817423815986 0.346386393900536 no 1168 0.35538676141192 1600 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1 SGTC_1982 st072467 71.9 µM 0.369825800302988 0.346774437935288 no 1169 0.35575614509498 1636 3163533 SGTC_1074 carmofur 3.8 µM 0.369365021971262 0.346954805347233 no 1170 0.355927832972084 1684 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_886 0866-0150 153 µM 0.368582862273644 0.347261053907052 no 1171 0.356219335738607 1805 271463 SGTC_1830 st055982 50.3 µM 0.368535005764328 0.347279794992376 no 1172 0.356237174090983 1812 455313 An antimicrobial agent. SGTC_193 1273-0060 1.558 µM 0.367062402350903 0.347856663484335 no 1173 0.356786235662968 1719 2847393 YHR072W ERG7 SGTC_1062 mesoridazine 14.2 µM 0.366590633875162 0.348041545717365 no 1174 0.35696219782075 1687 4078 A neuroleptic. SGTC_1812 st052057 4.327 µM 0.366200362535872 0.34819451719192 no 1175 0.357107785843307 1637 3645418 SGTC_60 0986-0278 202 µM 0.366087410735214 0.348238794598327 no 1176 0.357149925614486 1502 3110598 SGTC_2978 9011784 42.97 µM 0.365556561332474 0.348446916673988 no 1177 0.357347996894158 1860 2994934 SGTC_582 0987-0078 156 µM 0.365210738054464 0.348582522913941 no 1178 0.357477051645603 1693 1625765 SGTC_1223 0764-0573 147 µM 0.362635780064141 0.349592837883229 no 1179 0.358438489237984 1669 1609797 SGTC_2474 5321570 43.32 µM 0.361994367546325 0.349844669769953 no 1180 0.358678119736877 1776 2841384 SGTC_1104 tacrolimus 29.8 µM 0.360046759890654 0.350609745518848 no 1181 0.359406082910152 1706 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41 SGTC_2137 5261020 140 µM 0.357739373429071 0.351516937204566 no 1182 0.360269182356685 1673 763655 SGTC_814 3342-0569 96 µM 0.356518963990703 0.35199710632947 no 1183 0.360725976335819 1707 4346283 SGTC_292 k038-0015 474 µM 0.355313035759833 0.3524718097783 no 1184 0.361177545333448 1732 46368540 SGTC_2361 9034121 116 µM 0.354607468527979 0.352749656995744 no 1185 0.361441840126857 1684 6496917 SGTC_1740 st038286 13.222 µM 0.354570784441487 0.352764105070498 no 1186 0.361455583239403 1728 716786 SGTC_549 1661-1316 519 µM 0.354198059199948 0.352910915424034 no 1187 0.361595228985795 1810 2857282 SGTC_1388 3346-4487 254 µM 0.354121602914175 0.352941033007658 no 1188 0.361623876481326 1744 3345614 SGTC_1256 0570-0116 285 µM 0.353739752258559 0.353091465025585 no 1189 0.361766964159649 1643 410638 SGTC_1009 4106-0057 9.87 µM 0.352036776442556 0.353762640324222 no 1190 0.362405341005972 1811 2928005 SGTC_1768 st044301 37.178 µM 0.351167372331276 0.354105464587285 no 1191 0.362731393201409 1647 3931349 SGTC_645 0845-0943 5.41 µM 0.349835771820382 0.354630771839185 no 1192 0.363230975634331 1703 1885106 SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM 0.349405628932268 0.354800519403828 no 1193 0.363392404017169 1930 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W SGTC_128 0906-2981 13.371 µM 0.349114288701144 0.354915507566303 no 1194 0.363501754916083 1794 6740226 SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM 0.348881757625199 0.355007294012846 no 1195 0.363589040518703 1739 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_3281 9140613 49.47 µM 0.348571068959799 0.355129944553848 no 1196 0.363705675325331 1603 16013766 SGTC_2243 6634756 200 µM 0.348527710080971 0.355147062529086 no 1197 0.363721953571536 1801 885676 SGTC_1036 k216-0215 33.5 µM 0.348095375216741 0.355317763220019 no 1198 0.363884278722959 1663 622330 SGTC_2091 4-phenylthiadiazole 200 µM 0.347504788349926 0.355550994164317 no 1199 0.364106060904862 1716 270010 SGTC_2641 levomentholum 100 µM 0.346496067880061 0.35594947693647 no 1200 0.364484969395383 1747 16666 SGTC_3277 9138724 49.47 µM 0.344617005416829 0.356692197218649 no 1201 0.365191159816131 1732 15943418 SGTC_2557 derrustone 83.84 µM 0.343519066435114 0.35712642161815 no 1202 0.365603999797743 1652 629853 An antioxidant. SGTC_1123 mangostin 811.285 nM 0.337929707450729 0.359339819142207 no 1203 0.36770807991149 1692 5281650 An antioxidant. SGTC_666 0272-0154 136 µM 0.33560955941553 0.36025999567026 no 1204 0.368582657178184 1746 6870312 SGTC_2992 9074591 71.4286 µM 0.33530864111288 0.360379400083607 no 1205 0.368696138001788 1746 17741321 SGTC_83 0170-0301 39.027 µM 0.334127631369937 0.360848156380163 no 1206 0.369141625135407 1763 3089716 SGTC_361 000s-0510 1.45 µM 0.334071046721247 0.360870620730497 no 1207 0.369162973774744 1730 660 SGTC_923 1900-2434 73.3 µM 0.333421898807664 0.361128369582658 no 1208 0.369407917550593 1681 5910570 SGTC_822 1487-0950 154 µM 0.332202713927373 0.361612626083655 no 1209 0.369868097303161 1847 1958375 SGTC_1505 k297-0037 20.6 µM 0.332071869657261 0.361664610215869 no 1210 0.369917495390922 1689 4089396 SGTC_2347 9049783 174.81 µM 0.330417242663446 0.362322209772662 no 1211 0.370542357355252 1792 6467988 YPL169C MEX67 SGTC_1945 st075991 56.6 µM 0.329899330263636 0.362528127678877 no 1212 0.370738014785543 1687 1084980 SGTC_519 k048-0011 62.8 µM 0.327948504789007 0.36330411720263 no 1213 0.371475299207244 1777 6836379 SGTC_302 1094-0063 18.9 µM 0.326199661818264 0.364000240463122 no 1214 0.372136648620769 1745 5440289 SGTC_115 0527-0192 112.043 µM 0.325782670789081 0.364166289246913 no 1215 0.372294395394414 1741 4233931 SGTC_461 N-acetylfarnesylcysteine 136 µM 0.325734697406062 0.36418539422442 no 1216 0.372312544992987 1769 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ). SGTC_3042 9091578 49.47 µM 0.325226996368424 0.364387602371136 no 1217 0.37250463908837 1773 25236497 SGTC_467 ro 31-8220 72.8 µM 0.324828323093517 0.364546413192569 no 1218 0.372655503604916 1856 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7 SGTC_3275 9138069 49.47 µM 0.322890625304928 0.365318622498945 no 1219 0.373389038146327 1785 17617007 SGTC_3155 9099265 49.47 µM 0.322329042274471 0.365542526238265 no 1220 0.373601716838304 1787 25236499 SGTC_1441 4106-0040 13 µM 0.32193175447406 0.365700952979084 no 1221 0.373752198077548 1748 2904180 SGTC_2889 9059656 51.95 µM 0.320449473501026 0.366292245219681 no 1222 0.374313813356112 1803 3949838 SGTC_1807 st050092 58.9 µM 0.318640442280668 0.367014310653083 no 1223 0.374999591107662 1742 5008496 SGTC_1579 chlormadinone acetate 49.4 µM 0.317563734851256 0.367444296459823 no 1224 0.375407943268316 1876 45114258 A steroidal progestin. SGTC_3057 9095946 49.47 µM 0.317303011346537 0.36754844206731 no 1225 0.375506846307495 1766 24540043 SGTC_2511 berberine 10.47 µM 0.316124536915978 0.368019303315991 no 1226 0.37595399162323 1726 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_1831 st055328 12 µM 0.316121624588104 0.368020467187016 no 1227 0.375955096846406 1856 1103068 SGTC_728 3030-5151 22.5 µM 0.31567437577614 0.368199218281116 no 1228 0.376124839035653 1777 3125388 SGTC_3138 9097216 49.47 µM 0.313879967647902 0.368916672581682 no 1229 0.376806102782742 1882 25237486 SGTC_260 nsc-65238 3.989 µM 0.312695474771876 0.369390516366747 no 1230 0.377256016950022 1818 3246252 SGTC_673 1082-0474 110 µM 0.311978841313769 0.369677294380304 no 1231 0.377528301781023 1724 3098046 SGTC_2953 9074162 66.49 µM 0.311787515595674 0.369753870210544 no 1232 0.377601006276082 1929 16451992 SGTC_42 0133-0086 60.653 µM 0.310043133516615 0.370452276162791 no 1233 0.378264077787844 1676 162923 Model of phenazepam hydroxylation. SGTC_328 k915-0120 63.5 µM 0.308267882727328 0.371163479808736 no 1234 0.378939251335591 1878 6624543 SGTC_882 0843-0131 351 µM 0.308087561897139 0.371235744880279 no 1235 0.379007852696 1880 5425421 SGTC_1791 st048313 56.1 µM 0.306449150629139 0.371892559556565 no 1236 0.3796313452086 1889 1204976 SGTC_2337 9009472 200 µM 0.306231473175946 0.371979851317762 no 1237 0.379714205310489 1864 5742383 SGTC_2731 amoxapine 43.43 µM 0.304282740848441 0.372761613424742 no 1238 0.380456246478644 1877 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine. SGTC_2829 7992743 58.44 µM 0.304105160861539 0.37283287831685 no 1239 0.380523887567626 1965 16462845 SGTC_1638 st008370 60.6 µM 0.30405715908248 0.372852142730504 no 1240 0.380542172308221 1746 24207134 SGTC_964 1287-0107 19.4 µM 0.303042830590902 0.373259294501704 no 1241 0.380928610607666 1878 51516812 YPR165W RHO1 SGTC_1501 4491-0275 38.4 µM 0.301662401236533 0.373813626620167 no 1242 0.381454716599905 1880 5104718 SGTC_3327 9140648 26.9345 µM 0.301403468905032 0.373917633899598 no 1243 0.381553424715508 1887 8029710 SGTC_2141 5621638 7.665 µM 0.300342732069285 0.374343803733827 no 1244 0.381957870698157 1900 2856238 SGTC_1080 nisoldipine 24.4 µM 0.300166550371306 0.374414602741643 no 1245 0.382025059115937 1768 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class. SGTC_1109 tnp00067 928.257 nM 0.298694530881488 0.375006302342162 no 1246 0.38258656519458 1764 676295 SGTC_338 4055-0136 114 µM 0.298554145417821 0.375062747710783 no 1247 0.382640128550147 1738 2900563 SGTC_2109 5483026 200 µM 0.297906115172192 0.375323338600604 no 1248 0.38288741026092 1796 759335 SGTC_1967 st070177 51.4 µM 0.297839626323183 0.375350078827029 no 1249 0.382912784427497 1843 5729214 SGTC_1058 3448-5425 97.3 µM 0.297437233675826 0.375511924312246 no 1250 0.383066360416943 1860 7279705 SGTC_854 0422-0053 192 µM 0.296047240703555 0.376071158813081 no 1251 0.38359700230639 1747 3596728 SGTC_742 0kpi-0133 140 µM 0.295372465805527 0.376342734273944 no 1252 0.383854682290068 1916 2728852 SGTC_2166 5933061 31.504 µM 0.294681623314537 0.376620839865876 no 1253 0.384118551304968 1884 2877375 SGTC_1185 1319-0113 81.3 µM 0.294436755178579 0.376719429377601 no 1254 0.384212092202891 1838 4672763 SGTC_2418 pentamidine 31.67 µM 0.292624901734491 0.377449172473232 no 1255 0.384904438853763 1806 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_2983 9022671 12.99 µM 0.292588472889091 0.377463849072892 no 1256 0.38491836284091 1952 6405161 SGTC_772 k072-0172 35.3 µM 0.292330783379377 0.377567673110373 no 1257 0.385016862250751 1686 5861980 SGTC_3301 9125354 19.7965 µM 0.291362346724076 0.377957938797111 no 1258 0.385387104418152 1747 41905162 SGTC_1762 st045503 25.4615 µM 0.290715296005096 0.378218760145576 no 1259 0.385634536056582 1765 4645554 SGTC_2044 5102272 200 µM 0.289999007937854 0.378507555285248 no 1260 0.385908498279403 1786 592666 SGTC_3120 9124077 49.47 µM 0.288924058379153 0.378941083933753 no 1261 0.386319746284161 1869 18774327 YGL155W CDC43 SGTC_3274 9138298 49.47 µM 0.287399193875359 0.379556325119301 no 1262 0.386903339184736 1865 17015756 SGTC_2162 5663267 200 µM 0.286251890873923 0.38001943177019 no 1263 0.387342601261819 1889 6456493 SGTC_91 0417-1751 58.384 µM 0.284689598667502 0.380650324629152 no 1264 0.387940980054026 1854 6795624 SGTC_3212 9128307 49.47 µM 0.284543745479407 0.380709240043223 no 1265 0.387996857380868 1626 27243542 SGTC_680 0417-1641 114 µM 0.284247178192964 0.380829042899885 no 1266 0.388110481432102 1778 2835990 SGTC_1629 st005085 44.9 µM 0.284016846432058 0.380922096794841 no 1267 0.38819873522491 1727 24207091 SGTC_2526 patulin 37.61 µM 0.283626535365144 0.381079797956552 no 1268 0.388348299781087 1827 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.  SGTC_2761 levamisole 97.89 µM 0.283313885210217 0.381206135277541 no 1269 0.388468117146978 1916 26879 An alkaline phosphatase inhibitor. SGTC_3259 9138485 49.47 µM 0.282812019483927 0.381408958293024 no 1270 0.388660470054727 1907 17646153 SGTC_2519 cryptotanshinone 88.04 µM 0.282407978426871 0.381572270312266 no 1271 0.388815348990771 1884 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE) SGTC_3295 9122362 53.5725 µM 0.281293666271068 0.382022780672158 no 1272 0.389242583929214 1762 4730473 SGTC_2859 9028643 45.46 µM 0.281254939071181 0.382038440745774 no 1273 0.389257434614965 1899 17151580 SGTC_314 1671-0008 2.74 µM 0.280987721793378 0.382146500350289 no 1274 0.38935990860031 1839 3913060 SGTC_1770 st043884 66.3 µM 0.279987611497712 0.382551014908276 no 1275 0.389743504759873 1804 670149 SGTC_2536 dehydroabietamide 32.04 µM 0.278497094857945 0.383154121851704 no 1276 0.390315397417615 1916 3983547 SGTC_2965 9082772 38.63 µM 0.277343465518859 0.38362110886272 no 1277 0.390758193685962 1962 16459634 SGTC_2354 9060492 162 µM 0.277130403325521 0.383707374560933 no 1278 0.39083998862868 1911 6471895 SGTC_2552 juarezic acid 87.02 µM 0.27675529227569 0.383859265424228 no 1279 0.390984006141059 1906 1549512 SGTC_1383 3049-0032 20.7 µM 0.276753553799788 0.383859969413606 no 1280 0.390984673634157 1932 712864 SGTC_1286 0929-0070 131 µM 0.274199543314228 0.384894619240457 no 1281 0.391965639529099 1890 1420408 SGTC_1091 telmisartan 47.6 µM 0.273910132966626 0.385011913530848 no 1282 0.392076842156065 1893 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension. SGTC_2186 6124449 200 µM 0.273351733730206 0.385238255286837 no 1283 0.392291425603477 1890 3834182 YLR033W RSC58 SGTC_1127 asiatic acid 681.4 nM 0.273303733318064 0.385257713617988 no 1284 0.39230987288541 1745 470603 A kinase inhibitor which arrests cells at G2/M. SGTC_1425 4048-4433 7.33 µM 0.272752327118697 0.385481262499617 no 1285 0.3925218039477 1917 23734946 SGTC_2778 tioconazole 65.09 nM 0.271337667871577 0.386054961831978 no 1286 0.393065668981026 1795 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_453 enantio-paf c16 10 µM 0.271286627719622 0.3860756652645 no 1287 0.393085295250382 1858 13871343 A lipid and platelet activating factor SGTC_1238 0333-0287 48.8 µM 0.271234458679136 0.386096826943702 no 1288 0.393105355887654 1811 7226 SGTC_385 1494-0393 12.4 µM 0.26983025599943 0.386666550261683 no 1289 0.393645422476913 1865 3090647 SGTC_311 1315-0136 58 µM 0.269605932688435 0.386757587012894 no 1290 0.393731717843196 1914 6759207 SGTC_1547 harmine 94.2 µM 0.269482143455332 0.38680782685724 no 1291 0.393779340796552 1818 5280953 A monoamine oxidase inhibitor YHR072W ERG7 SGTC_3106 9121286 49.47 µM 0.268654446400974 0.387143796304524 no 1292 0.394097804904482 1926 15943471 SGTC_409 arachidonic acid 100 µM 0.267726023287229 0.387520751953714 no 1293 0.394455108562471 1842 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes. SGTC_1855 st056195 39.6 µM 0.266838886456277 0.387881043765667 no 1294 0.394796606183944 1963 4028379 SGTC_890 0929-0006 47.2 µM 0.266209308085522 0.388136792259345 no 1295 0.395039007394156 1779 1378169 SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM 0.265844819326405 0.388284877742611 no 1296 0.395179361979651 1998 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis. SGTC_3006 9075424 71.4286 µM 0.265760364439653 0.38831919262195 no 1297 0.395211885172625 1787 7465181 SGTC_1350 1495-0454 146 µM 0.264398938135122 0.388872474095008 no 1298 0.395736264834084 1925 1069057 SGTC_1883 5-benzylidenerhodanine 20 µM 0.264289776086653 0.38891684715557 no 1299 0.395778318895122 1962 1273210 SGTC_1404 3909-7820 48.3 µM 0.263639114350992 0.389181363371608 no 1300 0.396029007797114 1949 23741373 SGTC_1615 st002656 86.5 µM 0.262287771141819 0.389730894528193 no 1301 0.396549794655152 1826 1584458 SGTC_2537 larixol 68.93 µM 0.262256545133527 0.389743595367199 no 1302 0.396561830863523 1872 6708759 SGTC_2314 7727897 200 µM 0.260807829482737 0.39033297392155 no 1303 0.397120353153224 1777 900724 SGTC_1437 4092-1038 11.6 µM 0.260638273049071 0.390401970787662 no 1304 0.397185735939978 1843 3977136 SGTC_1046 2001-0062 216 µM 0.259097200272238 0.391029230873374 no 1305 0.397780122460365 1807 739778 SGTC_2908 7930301 100 µM 0.258017038731667 0.391469056233344 no 1306 0.398196878666366 1829 2223178 SGTC_524 r073-0010 27.8 µM 0.257983112755753 0.391482872625953 no 1307 0.398209970130426 1793 2772106 SGTC_623 k072-0108 16.9 µM 0.257931848720068 0.391503750223016 no 1308 0.398229752277802 1862 5382803 SGTC_714 4296-0578 26.1 µM 0.257579355625822 0.391647313685558 no 1309 0.398365782015041 1978 1589775 SGTC_2840 9008771 71.43 µM 0.257442185422041 0.391703184385284 no 1310 0.398418720368045 2002 2992978 SGTC_658 3253-0951 102 µM 0.256146647362838 0.392230979110484 no 1311 0.398918801871927 1872 1184878 SGTC_2898 9056270 58.44 µM 0.255284752983438 0.392582219826416 no 1312 0.399251587629297 1879 19154699 SGTC_1696 st025591 34.7925 µM 0.254437218395131 0.392927693952436 no 1313 0.399578900344125 1851 2787147 SGTC_1878 temozolomide 1 mM 0.254087428240923 0.393070300880327 no 1314 0.399714007770479 2010 5394 DNA alkylating agent. SGTC_1970 st070122 35.8 µM 0.253610127731456 0.393264916010761 no 1315 0.39989838579816 1939 102928 SGTC_503 tyrphostin 8 294 µM 0.252043392637867 0.39390392585863 no 1316 0.400503761863521 1970 92970 A tyrosine kinase inhibitor. YOR207C RET1 SGTC_575 k072-0246 11.9 µM 0.248612031250329 0.395304439795444 no 1317 0.401830450530552 1869 6796779 SGTC_1288 0973-0013 65.5 µM 0.247886729745422 0.395600646282595 no 1318 0.402111023829461 1881 4315430 SGTC_1268 0828-0275 2.46 µM 0.247687413254078 0.395682055882673 no 1319 0.402188135621914 1921 745337 SGTC_2667 digitoxin 100 µM 0.247438152722333 0.395783871224858 no 1320 0.402284575178964 2001 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_1020 4335-0961 93.3 µM 0.24653736499317 0.396151874841604 no 1321 0.402633141875516 1779 669075 SGTC_651 3253-0966 34.4 µM 0.244854192556451 0.396839758089796 no 1322 0.403284665589468 1869 781462 SGTC_1457 k015-0032 57.3 µM 0.244053142732957 0.397167246110413 no 1323 0.403594831016457 1849 4302660 SGTC_3286 9117135 37.221 µM 0.24386093966907 0.397245834042296 no 1324 0.403669260815314 1798 3438150 SGTC_2708 st078559 56 µM 0.243144855673653 0.397538662956064 no 1325 0.40394659191226 1957 17250902 SGTC_2126 5251174 33.877 µM 0.242545263566257 0.397783899160232 no 1326 0.404178844192163 2019 790722 SGTC_93 0109-0045 59.227 µM 0.242003715251301 0.39800542988296 no 1327 0.404388642216271 1996 88733 SGTC_1212 0520-0165 585 µM 0.240472723081372 0.398631889268161 no 1328 0.40498190338229 2036 5403258 SGTC_1492 4158-0558 28.5 µM 0.237537873072138 0.399833515775068 no 1329 0.406119770669918 1970 3967268 SGTC_1994 st072947 40.9 µM 0.236691089479098 0.400180394463512 no 1330 0.406448224067577 1909 5286565 YDL195W SEC31 SGTC_836 0330-0104 1.35 µM 0.235925627000737 0.400494028344654 no 1331 0.406745191008236 1916 46494820 SGTC_2112 5488546 200 µM 0.234319545728857 0.401152298340592 no 1332 0.407368456481187 1897 600757 SGTC_675 1309-0189 238 µM 0.232291545379973 0.401983897287334 no 1333 0.408155789337884 1869 4246530 SGTC_1729 st035615 45.989 µM 0.231497330756037 0.402309692990557 no 1334 0.408464229437727 1855 17385451 SGTC_1695 st026914 34.495 µM 0.231451540251973 0.402328478837975 no 1335 0.408482014305922 1872 3289191 SGTC_2617 dihydrotanshinone i 20.83 µM 0.229923699375938 0.402955414412902 no 1336 0.409075530091614 1857 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12 SGTC_244 nsc-207895 1.295 µM 0.229778806030361 0.403014883058045 no 1337 0.409131827223521 1877 42640 SGTC_249 wiskostatin 11.211 µM 0.229642083151723 0.403071000351816 no 1338 0.409184951505712 1988 2775510 A n-wasp and actin depolymerizer. SGTC_1243 0416-0003 5.65 µM 0.229591934327066 0.403091584213007 no 1339 0.409204437472585 1870 2141977 SGTC_2057 5236571 38.335 µM 0.229545563094589 0.40311061777965 no 1340 0.409222455807372 1998 54684039 YBR257W POP4 SGTC_2665 lovastatin 100 µM 0.229375979529301 0.403180227116202 no 1341 0.409288352032547 1904 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1 SGTC_1499 4480-0877 67.3 µM 0.229109988077148 0.403289415388213 no 1342 0.40939171528065 1990 2861909 SGTC_1446 4239-0190 62 µM 0.227920237618577 0.403777894671875 no 1343 0.409854124704723 1869 1340085 SGTC_2547 epiafzelechin trimethyl ether 100 µM 0.227728031566195 0.403856823370526 no 1344 0.40992883945503 2042 6708630 An antioxidant. SGTC_1406 3909-7906 11.9 µM 0.227501660109411 0.403949786985454 no 1345 0.410016839248703 1959 X1406 SGTC_2541 muurolladie-3-one 83.07 µM 0.227218008981073 0.404066281211867 no 1346 0.410127112377587 1928 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils.  YMR203W TOM40 SGTC_3344 9148862 3.898 µM 0.226192561387863 0.40448749877534 no 1347 0.410525827927287 1984 4905352 SGTC_3328 9140624 29.0385 µM 0.225586892511037 0.404736338150954 no 1348 0.410761368173747 2006 4904392 SGTC_1476 4112-3294 3.34 µM 0.224740219217781 0.405084258877954 no 1349 0.411090687218905 1986 704369 SGTC_789 1309-1135 70.6 µM 0.224394574369537 0.405226315184823 no 1350 0.4112251460417 1877 3092424 SGTC_1447 4239-0816 81.9 µM 0.223397922378505 0.405635998261438 no 1351 0.411612910587755 1837 1341554 SGTC_2740 felodipine 17.08 µM 0.223302906847597 0.405675060684754 no 1352 0.411649882523226 2034 3333 L-type calcium channel blocker SGTC_2485 5633444 17.78 µM 0.223266594198695 0.405689989650829 no 1353 0.411664012514258 1837 5724239 SGTC_924 2046-0044 21.3 µM 0.22263579941405 0.405949345781233 no 1354 0.41190948587231 2005 3623589 SGTC_1480 1070-0044 41.2 µM 0.222587521353359 0.4059691973796 no 1355 0.411928274668005 1996 3124987 SGTC_2174 5790901 200 µM 0.22187327960794 0.406262916774051 no 1356 0.41220626595048 1906 786020 SGTC_688 0527-0193 473 µM 0.220097485283244 0.406993409368396 no 1357 0.412897616623188 1941 4007154 SGTC_816 0325-0417 81.3 µM 0.219597153360623 0.407199284980671 no 1358 0.413092454294755 1892 68101 SGTC_795 0685-0265 78 µM 0.218953943928169 0.407463989216712 no 1359 0.413342962318245 1950 302754 SGTC_2812 7970281 58.44 µM 0.215715711231789 0.408797280121588 no 1360 0.414604676873077 2001 2233435 SGTC_1860 st056228 74.6 µM 0.215703460203217 0.408802326303101 no 1361 0.414609451930753 1888 688679 SGTC_3176 9106582 49.47 µM 0.21299223890224 0.409919444971792 no 1362 0.415666508128007 2044 17018027 SGTC_2190 6049624 200 µM 0.212733519587776 0.410026084819615 no 1363 0.415767410144029 1995 2265554 SGTC_37 0566-0070 1.56 µM 0.210255040195422 0.411048009410497 no 1364 0.416734311819137 2009 1626686 SGTC_1875 nocodazole 6 µM 0.210069827205438 0.411124400617203 no 1365 0.416806587217613 2057 4122 A microtubule depolymerizer. YJL014W CCT3 SGTC_157 1348-1695 65.819 µM 0.20961379666349 0.411312505041987 no 1366 0.416984555340744 1922 5380510 SGTC_757 1066-0008 322 µM 0.209434073039473 0.411386643419354 no 1367 0.417054698029258 2014 6842497 SGTC_1651 st011928 86.1 µM 0.206119225240869 0.412754626842406 no 1368 0.418348890816388 1984 720198 SGTC_1359 1582-0056 520 nM 0.205548902098908 0.412990097233889 no 1369 0.418571647648791 1991 3661189 SGTC_766 1391-0721 126 µM 0.205228242149681 0.413122502467355 no 1370 0.418696902496482 2023 1020919 YIL115C NUP159 SGTC_1592 4',5'-dihydroxyflavone 8.85 µM 0.204836169769102 0.413284408376986 no 1371 0.41885006336925 1884 688669 SGTC_1168 k815-0004 80.5 µM 0.20420818985666 0.413543762790285 no 1372 0.419095405814278 1938 642433 SGTC_1008 4106-0037 6 µM 0.203886963005953 0.413676443410553 no 1373 0.41922091655389 1940 2905394 SGTC_3128 9127691 49.47 µM 0.202353766938746 0.414309855414473 no 1374 0.419820084657987 1967 41316314 SGTC_1709 st033179 39.1045 µM 0.200537176154846 0.415060635215694 no 1375 0.420530243043722 1978 573381 SGTC_472 calcifediol 10 µM 0.200488751264044 0.415080653023533 no 1376 0.420549177298367 1964 5283731 A vitamin D metabolite. SGTC_1594 piperine 70.1 µM 0.199457125553793 0.415507157188593 no 1377 0.420952589161345 1901 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_2729 fluphenazine 10.66 µM 0.197012108019616 0.416518395519467 no 1378 0.42190903132382 1996 3372 An atypical antipsychotic. SGTC_121 0557-0495 61.343 µM 0.195278575651713 0.41723570497157 no 1379 0.422587434173992 1937 3104427 SGTC_687 k029-0044 34.9 µM 0.194562300671188 0.417532169303479 no 1380 0.422867809344748 2095 5829338 SGTC_2462 5162487 171.77 µM 0.194352040395234 0.417619204387634 no 1381 0.422950120022577 2080 2259986 SGTC_1239 0337-0584 35.4 µM 0.194140967324719 0.417706579978992 no 1382 0.42303275226861 2073 914301 YML130C ERO1 SGTC_92 0063-0024 660.874 µM 0.193599899521362 0.417930578397087 no 1383 0.423244588436566 2098 3594437 SGTC_3252 9135871 49.47 µM 0.192293585286874 0.418471493281991 no 1384 0.423756121418882 2032 17682838 SGTC_3033 9090887 49.47 µM 0.191252703333418 0.418902609166153 no 1385 0.424163807153292 1931 19325384 SGTC_1456 k015-0012 13 µM 0.190282031846527 0.419304732834676 no 1386 0.42454406646576 2125 2989616 SGTC_1355 1499-0035 1.68 µM 0.190074105427601 0.419390882258814 no 1387 0.424625530520606 1938 1548538 SGTC_88 0180-0332 8.668 µM 0.189527912751767 0.419617202752563 no 1388 0.424839540156794 1997 3101745 SGTC_3325 9138760 55.175 µM 0.189175603413621 0.419763199824982 no 1389 0.424977594031983 1923 43844959 SGTC_53 0973-0023 39.979 µM 0.189115304172271 0.419788188952197 no 1390 0.425001223462424 2124 674768 SGTC_3134 9127454 49.47 µM 0.187378451968479 0.420508111249939 no 1391 0.425681958108975 2109 24262820 SGTC_873 0591-4978 488 µM 0.187258515799783 0.420557834433881 no 1392 0.425728973594784 2107 3305145 SGTC_671 0560-0003 407 µM 0.185010263719447 0.421490149414215 no 1393 0.426610492632063 2024 3238678 SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM 0.18462018424761 0.421651954242118 no 1394 0.426763476674701 1972 115019 SGTC_3149 9097855 49.47 µM 0.182943875228515 0.422347436879683 no 1395 0.427421028169072 2067 25236625 YMR079W SEC14 SGTC_3247 9135149 49.47 µM 0.182402234199627 0.422572209807839 no 1396 0.42763353629052 2059 8934436 YOR116C RPO31 SGTC_3291 9121177 71.43 µM 0.181475437209517 0.422956875145922 no 1397 0.427997205651965 1945 17015612 SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM 0.180116595464257 0.423520992563402 no 1398 0.428530517188954 1984 6312947 SGTC_2925 9010536 32.5 µM 0.179927418864043 0.42359954089086 no 1399 0.428604774666127 2010 2994177 SGTC_78 0336-0123 156.75 µM 0.179923214106554 0.423601286789637 no 1400 0.428606425188003 1886 6765896 SGTC_1493 4348-0038 111 µM 0.179838446189288 0.423636484431467 no 1401 0.428639699977798 2040 800424 SGTC_1026 k007-1105 30.6 µM 0.178331932471343 0.424262125901167 no 1402 0.4292311511241 1935 7066794 SGTC_106 0092-0003 11.579 µM 0.177881482023517 0.424449231027858 no 1403 0.429408027055862 2096 1072148 SGTC_80 0159-0065 512.242 µM 0.177720484668645 0.424516109176403 no 1404 0.429471248453015 2105 1548079 SGTC_2687 chenodiol 100 µM 0.176764331205918 0.424913339133295 no 1405 0.429846753690954 2000 5702181 A cholesterol synthesis inhibitor. SGTC_513 4245-1575 41.7 µM 0.176374562061923 0.425075288995136 no 1406 0.429999843953896 2061 719745 SGTC_898 1000-0849 28.3 µM 0.176352235847481 0.425084565965223 no 1407 0.430008613376496 2103 6751807 SGTC_1983 st071813 46.9 µM 0.174663816257551 0.425786256507685 no 1408 0.430671900547096 1987 11838595 SGTC_295 k015-0027 31 µM 0.174522552969686 0.425844974825326 no 1409 0.43072740401563 2032 3887424 SGTC_455 paf C-16 10 µM 0.174419229946223 0.425887923713865 no 1410 0.430768001319257 2009 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis. SGTC_2327 6189656 200 µM 0.174363571900168 0.425911059785444 no 1411 0.430789870577922 2079 5349088 SGTC_1086 cerivastatin 2.18 µM 0.173781715116742 0.426152942679589 no 1412 0.431018507476942 2111 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7 SGTC_21 0849-0113 22.993 µM 0.172665001470003 0.426617247951999 no 1413 0.431457377659415 1999 1560156 SGTC_1486 3970-0793 4.53 µM 0.172371041909666 0.426739486887641 no 1414 0.431572918311877 2121 2844330 SGTC_1273 0849-0096 14.1 µM 0.169989406039858 0.42773011500983 no 1415 0.432509234075281 1978 5286025 SGTC_1371 2421-0008 32.7 µM 0.169138181886551 0.428084287816994 no 1416 0.432843976378319 1970 2827552 SGTC_258 haloperidol 50.781 µM 0.169106906622488 0.428097301767413 no 1417 0.432856276236703 1936 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_1451 4152-0210 104 µM 0.167952356857614 0.428577776097934 no 1418 0.433310380137138 2101 659563 SGTC_2585 alliin 100 µM 0.167858551447041 0.428616818566015 no 1419 0.433347279263762 2039 87310 A garlic compound which reacts with lipids. SGTC_26 0302-0163 425.158 µM 0.167643263132977 0.428706425709214 no 1420 0.433431966881972 2019 3100915 SGTC_3055 9094636 49.47 µM 0.166047972960699 0.429370530421066 no 1421 0.434059598600161 2062 25236176 SGTC_1155 4088-0394 48.2 µM 0.165182917130405 0.429730728982507 no 1422 0.434400005357336 1949 2326248 SGTC_1116 jasmonic acid  1.58368 µM 0.16515804987733 0.429741084265936 no 1423 0.434409791551394 2083 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid. SGTC_1839 st053978 48 µM 0.164979837577513 0.429815297289511 no 1424 0.434479925931855 2123 3788398 SGTC_700 3453-2283 142 µM 0.164954673961371 0.429825776384718 no 1425 0.434489829088074 2081 565664 SGTC_3199 9111318 49.47 µM 0.163962816145322 0.430238863338324 no 1426 0.434880208006801 2066 8548020 SGTC_1108 betulinic acid 729.144 nM 0.163213077154477 0.43055116383192 no 1427 0.435175335094583 1995 64945 Apoptosis-inducing agent of unknown mechanism. SGTC_1318 1280-3875 124 µM 0.162287488495089 0.430936773635082 no 1428 0.435539733404867 2057 373245 SGTC_734 2023-0417 80 µM 0.161587241578504 0.431228547512438 no 1429 0.435815452507292 2063 3935732 SGTC_2680 butyl paraben 22.24 µM 0.161368524300738 0.431319688763478 no 1430 0.43590157786117 2120 7184 An antifungal and steroid mimetic. SGTC_2630 antimycin a 100 µM 0.160214144824341 0.431800788461964 no 1431 0.436356193683055 2056 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain. SGTC_835 0312-0010 67.2 µM 0.160199907096665 0.43180672281666 no 1432 0.436361801287657 1997 1626196 SGTC_357 1325-0123 420 µM 0.159938361184937 0.431915739171413 no 1433 0.436464814807365 2128 1098503 SGTC_771 0250-0039 27.3 µM 0.159759102951876 0.431990459752427 no 1434 0.436535420661863 2004 3005115 SGTC_659 k018-0002 107 µM 0.157484577261279 0.43293876541437 no 1435 0.437431480894443 2146 6797879 YHR007C ERG11 SGTC_1959 st077091 55.8 µM 0.155082008858171 0.433940874706525 no 1436 0.438378332716826 2068 821356 YKL052C ASK1 SGTC_1847 st056231 15 µM 0.154734072051249 0.434086034220194 no 1437 0.438515483933074 2127 5393180 SGTC_1936 st074407 74.3 µM 0.154685514742537 0.434106293075418 no 1438 0.438534625047894 1953 809813 SGTC_502 l-744,832 89.3 µM 0.153573404584462 0.434570329789492 no 1439 0.438973054101014 2137 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.  SGTC_920 mycophenolic acid 780.421 nM 0.153243143500191 0.434708151216202 no 1440 0.439103267927611 2003 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_1292 0kpi-0043 232 µM 0.152638812687103 0.434960365357094 no 1441 0.43934155776391 2020 3333905 SGTC_3090 9117696 49.47 µM 0.152082154110318 0.435192707172241 no 1442 0.439561069715381 2129 7923821 SGTC_2816 7982706 58.44 µM 0.152000790118393 0.43522666928621 no 1443 0.43959315623452 2009 2981853 SGTC_2499 avocadenofuran 51.48 µM 0.149271904628949 0.436366007589806 no 1444 0.440669541863947 2013 6857792 A insecticide and lysyl oxidase inhibitor. SGTC_55 0767-0285 6.563 µM 0.148700658541343 0.436604575989346 no 1445 0.440894920787599 2145 3116166 SGTC_1244 0416-0015 52.5 µM 0.148299087067693 0.436772297316481 no 1446 0.441053367904165 2035 96201 SGTC_932 2857-0803 154 µM 0.147624138192703 0.437054223711949 no 1447 0.441319702148086 2145 674898 SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM 0.146572447845165 0.437493578824303 no 1448 0.441734751100678 2046 6708514 SGTC_547 1120-0019 610 nM 0.145383582409646 0.437990333121342 no 1449 0.442204013141331 2041 3676939 SGTC_1490 4089-0339 670 nM 0.141247051274448 0.439719493665945 no 1450 0.443837388547551 2160 742542 SGTC_2428 5615643 7.78 µM 0.140783643140585 0.439913280685713 no 1451 0.444020432620268 2115 2253075 SGTC_297 0986-0032 24 µM 0.140334644712188 0.440101055618128 no 1452 0.44419779631725 2056 2847425 SGTC_2614 arthonioic acid 13.39 µM 0.140284366416239 0.440122083265466 no 1453 0.444217657983997 2148 6710684 SGTC_2452 5863136 48.41 µM 0.140205309407925 0.440155147235336 no 1454 0.444248888521296 2126 2184096 SGTC_2089 5281248 129.67 µM 0.140123248258432 0.44018946806697 no 1455 0.444281306175228 2060 2737878 SGTC_1722 st034304 3.6505 µM 0.13973767820438 0.440350732908571 no 1456 0.444433627777868 2043 4036148 YLR033W RSC58 SGTC_284 0988-0104 32.6 µM 0.138799563012903 0.44074314126506 no 1457 0.44480426965415 2143 4666532 SGTC_1188 1403-0014 4.57 µM 0.138319517862361 0.440943964009206 no 1458 0.444993950375999 2033 9614867 SGTC_818 4072-2707 53.5 µM 0.137728602241351 0.441191189306418 no 1459 0.445227456748021 2131 882871 SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM 0.137600100047258 0.44124495466087 no 1460 0.445278238227361 2171 551469 SGTC_3316 9136639 10.545 µM 0.137574211369254 0.441255786622172 no 1461 0.445288469020262 2105 4903665 SGTC_1744 st037937 38.9 µM 0.136910261583272 0.441533601754959 no 1462 0.445550863824548 2106 1016152 SGTC_2851 9015922 71.43 µM 0.13684396107915 0.441561345319462 no 1463 0.445577067280159 2121 2996893 SGTC_935 2996-0153 430 µM 0.136057671886445 0.441890391264768 no 1464 0.445887844612717 2186 23738523 SGTC_1617 st002906 78 µM 0.135845275804161 0.441979281569977 no 1465 0.445971798938269 2046 5150859 SGTC_949 1165-0505 146 µM 0.134167531308273 0.442681540081076 no 1466 0.446635050001136 2040 6244267 SGTC_3222 9128301 49.47 µM 0.13410298047217 0.442708562929392 no 1467 0.446660571428885 2098 4911358 SGTC_2113 5491891 107.031 µM 0.134031492995552 0.442738489967224 no 1468 0.4466888356501 2053 789979 SGTC_1152 3909-8331 15.9 µM 0.133151371451047 0.443106964869265 no 1469 0.447036834131651 2030 16001939 SGTC_948 3448-0295 75.3 µM 0.133106950856652 0.443125563464751 no 1470 0.447054399038449 2133 678569 SGTC_525 k781-2675 26.7 µM 0.131819836841043 0.44366452345204 no 1471 0.44756339797004 2195 3651118 YDL195W SEC31 SGTC_2803 7707263 71.43 µM 0.131375303117887 0.443850689648239 no 1472 0.447739212286532 2064 2199229 SGTC_1659 st012954 42.1 µM 0.130565121406748 0.444190017341918 no 1473 0.448059667779401 2126 24207262 SGTC_252 miconazole 1.30953 nM 0.129210192006017 0.444757592537975 no 1474 0.4485956658809 2164 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_940 3232-1287 54.8 µM 0.128888340304 0.444892431786328 no 1475 0.448723001400919 2215 1585493 YIL048W NEO1 SGTC_353 1988-1175 58.3 µM 0.128398531786114 0.445097648501657 no 1476 0.448916796502801 2025 2788357 SGTC_1711 st032263 62.8 µM 0.12769725235649 0.445391491494699 no 1477 0.449194282296679 2100 3958979 SGTC_432 NS 1619 61.3 µM 0.127576564516492 0.445442063919699 no 1478 0.449242039182078 2054 4552 A K+/calcium channel activator. SGTC_1045 1348-1485 165 µM 0.127183901146976 0.445606609740645 no 1479 0.449397423462511 2178 6810614 SGTC_2359 9039622 200 µM 0.126262405981539 0.44599279959078 no 1480 0.449762106863945 2117 6463596 SGTC_3226 9131256 49.47 µM 0.126011044542629 0.446098151687 no 1481 0.4498615909932 2179 17178073 SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM 0.125707590444579 0.446225342236718 no 1482 0.449981696614863 2175 279621 SGTC_927 2425-1185 123 µM 0.125224279346769 0.446427929942034 no 1483 0.45017299819721 2114 730375 SGTC_79 0052-0007 94.094 µM 0.124397896721245 0.446774354024027 no 1484 0.450500119293774 2166 2801472 SGTC_2491 paeonol 100 µM 0.124132501089178 0.44688561794363 no 1485 0.45060518250786 2064 11092 Increases levels of cortical cytochrome oxidase. SGTC_2271 7849410 118.62 µM 0.123281924857845 0.447242239905324 no 1486 0.45094192675742 2224 972430 SGTC_2230 bromochlorosalicylanilide 954.5 nM 0.123277041620811 0.447244287428517 no 1487 0.450943860139569 2180 77254 SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM 0.123112155176286 0.447313424528631 no 1488 0.451009143033003 2188 1377 SGTC_3241 9133421 49.47 µM 0.120647768977202 0.448346934489596 no 1489 0.451985015495242 2194 17018221 SGTC_901 1112-0062 60.1 µM 0.120451519647927 0.448429252356279 no 1490 0.452062740832557 2181 1908457 SGTC_2339 9000433 200 µM 0.120260509274791 0.448509374846218 no 1491 0.452138393024634 2039 2988954 SGTC_1705 st027868 56.3335 µM 0.119230099551323 0.448941633550799 no 1492 0.452546530369008 2195 292948 SGTC_2210 7115885 190.385 µM 0.118691122534705 0.449167759540521 no 1493 0.452760035010105 2160 2927039 SGTC_2575 plumbagin 510 nM 0.117792006176083 0.44954501748659 no 1494 0.453116231799412 2068 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_817 1391-0715 46 µM 0.117555257791484 0.449644361739031 no 1495 0.45321002907695 2073 1353946 SGTC_2850 9015429 58.44 µM 0.117510229303813 0.449663256930534 no 1496 0.453227869196754 2125 6457570 SGTC_956 1185-0240 191 µM 0.117149190134966 0.449814763015328 no 1497 0.453370914986134 2114 1416193 SGTC_3323 9138564 53.9225 µM 0.116535180922325 0.450072441962703 no 1498 0.453614202842284 2193 43912313 YNL103W MET4 SGTC_1730 st033808 45.1 µM 0.116279920767635 0.450179572237089 no 1499 0.453715349279957 2017 1045166 SGTC_1637 st007924 17.4 µM 0.113734507129158 0.451248055624125 no 1500 0.454724128631801 2181 683336 SGTC_3225 9130819 49.47 µM 0.113511936198218 0.45134150070549 no 1501 0.454812350263302 2189 4547121 SGTC_2605 digitonin 300 nM 0.111879759997801 0.452026842233672 no 1502 0.455459372508355 2219 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_3083 9117465 49.47 µM 0.111552423143414 0.452164306400392 no 1503 0.455589148652265 2042 16420915 SGTC_978 1416-0512 87.4 µM 0.111454995912722 0.452205221792747 no 1504 0.455627775619874 2118 6814003 SGTC_860 0443-0016 25.1 µM 0.111172504128946 0.452323859482788 no 1505 0.455739777488378 2222 5337942 SGTC_2164 5685496 200 µM 0.111130330817844 0.452341571316318 no 1506 0.455756498593989 2195 759046 SGTC_3109 9122853 49.47 µM 0.111059191463348 0.452371448445588 no 1507 0.455784704492874 2152 1234709 SGTC_1589 2',5'-dimethoxyflavone 47.2 µM 0.109387996977672 0.45307339447442 no 1508 0.456447376821088 2083 688667 SGTC_2993 9054257 71.4286 µM 0.10892269941377 0.45326885799261 no 1509 0.456631901116296 2206 6470217 YGL055W OLE1 SGTC_1965 Pectolinarigenin 58.4 µM 0.108332089885009 0.453516979216522 no 1510 0.456866134175737 2143 5320438 An anti-inflammatory. SGTC_2619 obliquin 87.91 µM 0.107342028423375 0.453932955021331 no 1511 0.457258821638141 2173 6708593 A bioactive alkalod. YER133W GLC7 SGTC_2593 nobiletin 86.24 µM 0.107119222396933 0.454026574289513 no 1512 0.457347198820445 2106 72344 An anti-infammatory. SGTC_2727 riluzole 51.77 µM 0.106451888419471 0.454306991835524 no 1513 0.457611912955334 2241 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.  SGTC_799 1310-0557 151 µM 0.10531329337696 0.454785488478089 no 1514 0.458063607522175 2126 5354492 SGTC_3069 9117009 49.47 µM 0.105028449776824 0.45490520480821 no 1515 0.458176616952058 2224 41904981 SGTC_1931 st074438 57.1 µM 0.103818260766975 0.455413878191925 no 1516 0.4586567873904 2219 2787313 SGTC_3056 9094900 49.47 µM 0.100701892562617 0.45672410194591 no 1517 0.459893554482829 2135 25236784 SGTC_1382 3002-2117 298 µM 0.100503838793768 0.456807386323351 no 1518 0.459972167677034 2229 1497314 SGTC_3166 9102297 49.47 µM 0.10013670973965 0.456961774236362 no 1519 0.460117895814663 2123 25237072 SGTC_13 0199-0087 65 µM 0.100060711435843 0.45699373443569 no 1520 0.460148063237023 2237 4589825 SGTC_589 1227-0070 34.1 µM 0.099060473086053 0.457414398840632 no 1521 0.460545127790278 2152 2841384 SGTC_1316 1272-0050 65.9 µM 0.0989469320012197 0.457462153176452 no 1522 0.46059020268133 2218 7340392 SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM 0.0981330717977366 0.457804473229432 no 1523 0.4609133133799 2237 756377 SGTC_2690 usnic acid 100 µM 0.0975730949008571 0.458040024897859 no 1524 0.461135644848076 2224 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_2959 9079155 11 µM 0.097100508780265 0.458238827514559 no 1525 0.461323288412097 2147 16189457 SGTC_2550 chrysin dimethyl ether 71.87 µM 0.0943532271520962 0.459394730719243 no 1526 0.462414284654332 2245 88881 An O-methylated flavonoid and antioxidant. SGTC_2907 7721985 69.9 µM 0.0942117416904272 0.459454269306777 no 1527 0.462470478870697 2150 3267881 SGTC_270 tamoxifen 5.46 µM 0.093502700112166 0.459752655217002 no 1528 0.462752102357435 2269 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  YIL048W NEO1 SGTC_1596 piperlongumine 63 µM 0.0933382440271438 0.45982186650304 no 1529 0.462817425171448 2245 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_2065 5221596 34.26 µM 0.0926828737181305 0.460097690942092 no 1530 0.463077751616193 2197 788581 SGTC_902 1120-0002 2.07 µM 0.0914984709327692 0.460596216882403 no 1531 0.463548260580142 2234 3280475 SGTC_2814 7977482 42.97 µM 0.090586925906437 0.460979936723135 no 1532 0.463910410415838 2206 6456762 SGTC_1976 st070609 63.5 µM 0.0905681383855943 0.460987845815674 no 1533 0.463917874869089 2239 682556 SGTC_2413 inermin 26.06 µM 0.090530648904764 0.461003628027813 no 1534 0.463932769819439 2223 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1 SGTC_1272 0839-0021 27 µM 0.0893302768289585 0.461508989491198 no 1535 0.46440971640948 2180 5027250 SGTC_906 1165-0455 526 µM 0.0875047687248333 0.46227765460695 no 1536 0.465135147539599 2258 3252859 SGTC_2678 equilin 100 µM 0.086746286975318 0.462597069458569 no 1537 0.465436591687452 2268 3247 Equilin is an estrone commonly used hormone replacement therapy SGTC_345 1362-0200 395 µM 0.0853758153395546 0.46317426895002 no 1538 0.465981309756389 2125 1419823 SGTC_1769 st044406 64.4 µM 0.0848538977143435 0.463394104669305 no 1539 0.466188771915114 2105 670903 SGTC_1201 1889-3372 45.9 µM 0.0835736292616945 0.463933410798296 no 1540 0.466697717183765 2135 5392199 SGTC_1719 st032227 49.2 µM 0.0832037097789941 0.464089249755962 no 1541 0.466844781496641 2198 3125804 SGTC_3276 9139060 49.47 µM 0.0823645625371023 0.46444278445618 no 1542 0.467178407634736 2288 4870619 SGTC_1482 3346-2049 8.48 µM 0.0821755044889133 0.464522438940067 no 1543 0.467253576069118 2240 3826804 SGTC_187 1488-2104 32.728 µM 0.0821370187287772 0.464538654046168 no 1544 0.467268877937653 2231 2852859 SGTC_3256 9138902 49.47 µM 0.0818163791165524 0.464673750594124 no 1545 0.467396365544928 2268 17228773 SGTC_648 0375-0473 33.3 µM 0.0810950252874629 0.464977696751147 no 1546 0.467683190952354 2195 1713139 SGTC_2636 apigenin dimethyl ether 100 µM 0.0810084167730294 0.465014191073028 no 1547 0.46771762944481 2200 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_1893 st059353 36.1 µM 0.0797462935847515 0.46554604649838 no 1548 0.468219519856829 2116 3112488 SGTC_2256 7954252 200 µM 0.0793792925568828 0.465700711368629 no 1549 0.468365469403462 2146 2972920 SGTC_2391 6285546 200 µM 0.0778307140763477 0.466353384002135 no 1550 0.468981357123342 2262 846083 SGTC_2277 7947813 106.88 µM 0.0769254159900434 0.466734978075641 no 1551 0.469341439207488 2244 1246798 SGTC_2050 5263056 171 µM 0.0745005067312881 0.467757256295386 no 1552 0.470306068987947 2265 763468 YGL055W OLE1 SGTC_2653 dihydrofissinolide 100 µM 0.0735109970214788 0.468174469149621 no 1553 0.470699746697463 2225 6857746 SGTC_2092 5303694 80.6725 µM 0.0730563345169514 0.468366182950294 no 1554 0.470880644384386 2210 1963699 SGTC_2662 daunorubicin 22.37 µM 0.0728833945568473 0.468439107049973 no 1555 0.470949454010378 2246 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_2156 5649887 115 µM 0.0714111740853997 0.469059945202449 no 1556 0.471535258340696 2247 54680440 YKL052C | YBR257W ASK1 | POP4 SGTC_2906 7926292 26.41 µM 0.0707379868870974 0.469343854673968 no 1557 0.471803143692167 2194 2966319 SGTC_743 1275-0778 158 µM 0.0706581533449119 0.469377524649768 no 1558 0.471834913172858 2271 2849257 YMR203W TOM40 SGTC_3349 9149703 23.001 µM 0.0698435092287192 0.469721115112742 no 1559 0.472159108177284 2283 4910494 SGTC_108 0509-0257 621.132 µM 0.068106530250007 0.470453791472615 no 1560 0.472850416020928 2261 536624 SGTC_607 4491-0986 66.8 µM 0.0672330510137939 0.470822272337342 no 1561 0.473198086869019 2289 698981 YDR232W HEM1 SGTC_2122 5258151 111.688 µM 0.0656760126083493 0.471479177248831 no 1562 0.473817885168484 2234 2173356 SGTC_1002 4049-0206 172 µM 0.0631950081006591 0.472526057381953 no 1563 0.474805609897393 2265 4662749 SGTC_2340 7987427 183.45 µM 0.0628002688169998 0.472692638539366 no 1564 0.474962775904166 2274 2239331 SGTC_2929 9013348 24.6 µM 0.0627872817550252 0.472698119199646 no 1565 0.474967946787683 2244 2995952 SGTC_1332 1480-0653 17.5 µM 0.0625028975115979 0.472818133274864 no 1566 0.475081177286465 2308 5749438 SGTC_1788 fluconazole 20 µM 0.0621291847618644 0.472975848962766 no 1567 0.475229977903626 2153 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11 SGTC_2944 9067346 25.62 µM 0.0612431681880287 0.473349785959513 no 1568 0.475582775495663 2250 6473075 SGTC_62 0180-0423 3.232 µM 0.0609983965392427 0.473453094248157 no 1569 0.47568024302786 2247 30102 YGL099W LSG1 SGTC_1524 corynanthine 62.1 µM 0.0608402063886189 0.473519860911782 no 1570 0.475743234772446 2201 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist. SGTC_1881 5652484 16 µM 0.0602520943927652 0.473768089422 no 1571 0.475977427859435 2294 2255129 SGTC_2786 7743617 45.45 µM 0.0598943852341146 0.473919075196052 no 1572 0.476119875901286 2219 583674 SGTC_3244 9134489 49.47 µM 0.0597618609510313 0.47397501343977 no 1573 0.476172650904841 2190 16584271 SGTC_173 1273-0061 2.693 µM 0.0596767526418307 0.47401093776322 no 1574 0.476206543716279 2217 2847414 YPL266W DIM1 SGTC_214 4373-3496 70 µM 0.0596589491694398 0.474018452657857 no 1575 0.476213633641951 2244 3779166 SGTC_3093 9117344 49.47 µM 0.0596372647621249 0.474027605718281 no 1576 0.476222269093161 2235 24824913 SGTC_1467 k284-1082 293 µM 0.0595593616672546 0.474060488986713 no 1577 0.476253292785076 2313 3334705 SGTC_2754 granisetron 64.02 µM 0.0589355780189311 0.474323797398411 no 1578 0.476501710064395 2293 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients. SGTC_1902 st060212 70.5 µM 0.055165130104241 0.475915594575257 no 1579 0.478003454380051 2329 688944 SGTC_2330 7979373 200 µM 0.0550487723690387 0.475964724404811 no 1580 0.478049803970129 2266 1863007 SGTC_1211 1056-0033 32.3 µM 0.0541339488352931 0.476351003825997 no 1581 0.478414222316563 2309 6741922 SGTC_1375 2910-0797 186 µM 0.0540781329738866 0.476374572502678 no 1582 0.478436457054069 2267 742508 SGTC_3228 9131799 49.47 µM 0.0537762228149885 0.476502057819369 no 1583 0.478556726773053 2233 17015818 SGTC_466 geldanamycin 89.2 µM 0.0534608808485201 0.476635217451574 no 1584 0.478682349306696 2315 5288382 HSP90 inhibitor. SGTC_1096 rimcazole 32.2 µM 0.053392849897235 0.476663945262875 no 1585 0.478709451021945 2280 18528119 A dopamine reuptake inhibitor. SGTC_1207 2099-0101 141 µM 0.0533571137579391 0.476679035811413 no 1586 0.47872368738549 2320 5837381 SGTC_3124 9127567 49.47 µM 0.053115995144065 0.476780855521558 no 1587 0.478819743580527 2312 17592030 SGTC_1667 st014849 34.6 µM 0.052843858663596 0.476895775295303 no 1588 0.478928158068643 2294 5348460 SGTC_747 3448-8087 38.7 µM 0.0524659359748955 0.477055370424064 no 1589 0.479078718544921 2268 5168703 SGTC_3151 9099821 49.47 µM 0.0522031793306063 0.477166333597124 no 1590 0.479183399825189 2257 17174189 SGTC_164 4100-3994 89.624 µM 0.0515895054128489 0.477425497407577 no 1591 0.479427890836449 2314 4615967 SGTC_206 4546-0025 72.014 µM 0.0508329951695815 0.477744996294244 no 1592 0.47972929925594 2249 6620745 YIL048W NEO1 SGTC_2470 5664817 21.68 µM 0.0506688713922187 0.477814313000073 no 1593 0.479794690902393 2338 2859561 SGTC_3267 9137951 49.47 µM 0.049842906320451 0.47816316460415 no 1594 0.480123787427754 2228 16643986 SGTC_2322 7413319 38.22 µM 0.0497778111375883 0.47819065868363 no 1595 0.480149724452667 2266 1840400 SGTC_3127 9126946 49.47 µM 0.0494975451633121 0.478309035062554 no 1596 0.480261396739798 2190 27243249 SGTC_3071 9117417 49.47 µM 0.0491072535198173 0.478473886341518 no 1597 0.48041691145531 2310 45595590 YGL055W OLE1 SGTC_2143 5623677 140.463 µM 0.0490539108177773 0.478496417504299 no 1598 0.480438166498405 2315 5375313 SGTC_2215 7188065 200 µM 0.0484244403672816 0.478762301617209 no 1599 0.480688990776794 2316 940217 SGTC_1756 st041558 35.5 µM 0.0479860404338372 0.47894748441092 no 1600 0.480863683955396 2333 3955792 SGTC_917 harmaline 728.087 nM 0.0475194690781824 0.479144571975598 no 1601 0.481049606891 2275 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7 SGTC_2364 9055074 200 µM 0.0454875681284023 0.480002939843823 no 1602 0.481859341919502 2277 6470630 SGTC_487 nimodipine 119 µM 0.0453002164565055 0.480082090486884 no 1603 0.481934007454868 2324 4497 L-type voltage-gated calcium channels inhibitor SGTC_1128 3448-9350 235 µM 0.0441734468744942 0.480558134383083 no 1604 0.482383073855573 2201 619386 SGTC_1995 st072814 61.1 µM 0.0436667533504887 0.480772214167262 no 1605 0.482585020454397 2232 5769371 SGTC_997 3996-0078 137 µM 0.0436500921774006 0.480779253665612 no 1606 0.482591660969164 2289 735687 SGTC_3182 9108849 49.47 µM 0.0434057494636937 0.480882491389235 no 1607 0.482689047306646 2278 17133045 SGTC_1603 st002045 67.8 µM 0.0429664001569189 0.481068124955392 no 1608 0.482864158948564 2335 5887985 SGTC_2772 vinpocetine 57.06 µM 0.0428973382430255 0.481097305322039 no 1609 0.482891685286762 2302 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor. SGTC_3216 9129716 49.47 µM 0.0420766813148288 0.481444060879733 no 1610 0.483218784659617 2308 8056934 SGTC_337 1315-0038 354 µM 0.0406883237838783 0.482030721144654 no 1611 0.483772185079396 2305 1626437 SGTC_2380 9035439 200 µM 0.0401119158014109 0.48227429790658 no 1612 0.484001951006163 2300 6462575 SGTC_2285 7945142 200 µM 0.0395712125476452 0.482502792687267 no 1613 0.484217489257367 2309 2970608 SGTC_1877 wortmannin 25 µM 0.0388167244091935 0.482821640012815 no 1614 0.484518255366476 2345 312145 A covalent inhibitor of PI 3-kinase. SGTC_1157 4092-0394 27.6 µM 0.0387271768364182 0.482859483626182 no 1615 0.4845539528379 2339 3659885 SGTC_1755 st041960 45.185 µM 0.0382821640865489 0.483047552319168 no 1616 0.48473135567934 2303 2257073 SGTC_2022 5136654 200 µM 0.0382121700827897 0.483077133121194 no 1617 0.484759258830339 2306 1713771 SGTC_146 3448-8650 53.125 µM 0.0380402609582975 0.483149785593604 no 1618 0.484827790820961 2238 2891488 YIL048W NEO1 SGTC_2569 tetrandrine 100 µM 0.0378369719574433 0.483235700594683 no 1619 0.484908833053803 2274 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_2779 methotrexate 400 µM 0.0374877333200117 0.483383299366773 no 1620 0.485048060332831 2339 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2 SGTC_2692 st077426 47.7 µM 0.0374610880400159 0.483394560558777 no 1621 0.485058682800242 2330 25238571 SGTC_271 rotenone 740 µM 0.0373591333525478 0.483437650162959 no 1622 0.485099328383707 2279 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria. SGTC_3022 9087993 49.47 µM 0.0370384277504466 0.483573192786336 no 1623 0.485227182917482 2339 17173644 SGTC_1334 1486-0610 236 µM 0.0366307166055691 0.483745510064605 no 1624 0.485389725824881 2283 3742339 SGTC_1742 st038235 28.8875 µM 0.0354658554222893 0.484237850013481 no 1625 0.485854136331568 2287 564103 YBR002C RER2 SGTC_1241 0364-0022 50.8 µM 0.0315394647471564 0.485897550017283 no 1626 0.487419659735775 2317 4563895 SGTC_32 0928-0142 34.1 µM 0.0309906639792113 0.486129550269164 no 1627 0.48763849258172 2355 2244242 SGTC_2345 9052315 157.45 µM 0.0305129449272232 0.486331505233286 no 1628 0.487828984814877 2308 6469265 SGTC_430 0958-0115 16.4 µM 0.0285991107050868 0.487140610218766 no 1629 0.488592160675049 2232 6833180 SGTC_1953 st076800 12.1 µM 0.0285666254174909 0.487154344376224 no 1630 0.488605115136911 2235 297591 SGTC_2486 5283202 22.39 µM 0.0284483299723006 0.487204357553563 no 1631 0.488652289019106 2317 1377751 SGTC_3261 9137475 49.47 µM 0.026347283642448 0.488092674784587 no 1632 0.48949017054647 2356 17027690 SGTC_2480 5767542 37.17 µM 0.0262569314646742 0.488130876819961 no 1633 0.489526203384368 2343 2867358 SGTC_154 3389-1638 511.116 µM 0.025616548218136 0.48840164199914 no 1634 0.489781593415976 2238 5238686 SGTC_2438 5259590 200 µM 0.024919498098198 0.488696372990537 no 1635 0.490059587414755 2339 1201127 SGTC_2278 7948257 134.34 µM 0.0241659731543563 0.489014989950586 no 1636 0.49036010984423 2377 1247028 SGTC_3320 9137005 35.139 µM 0.023419681745034 0.489330555227247 no 1637 0.49065775277445 2270 4908713 SGTC_1030 k029-0042 36.7 µM 0.0232021927714449 0.489422520526315 no 1638 0.490744494750377 2256 6080581 SGTC_2508 celastrol 40.54 µM 0.0222212072564389 0.489837337559619 no 1639 0.491135750411071 2371 122724 Celastrol is a natural product and antioxidant. SGTC_2510 benzyl isothiocyanate 8.31 µM 0.0217337574249894 0.490043463468469 no 1640 0.491330167798072 2363 2346 DNA damaging agent; causes G2/M arrest. SGTC_1386 3228-0095 33.8 µM 0.0209512755741862 0.490374353893157 no 1641 0.491642261796071 2350 870181 SGTC_616 4092-0450 108 µM 0.0197880472651445 0.49086626387935 no 1642 0.49210622645934 2344 787165 SGTC_1826 st055655 41.6 µM 0.0188685666457981 0.491255106872038 no 1643 0.492472977629008 2301 676168 SGTC_325 2810-4341 181 µM 0.0186649228817485 0.491341227769559 no 1644 0.492554205431389 2373 774970 SGTC_394 menadione 8.33 µM 0.01814385911138 0.491561587337557 no 1645 0.492762044595035 2384 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_2217 6934799 96.0675 µM 0.0179329028305836 0.491650802172947 no 1646 0.492846190283695 2371 675606 SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM 0.0179284157117796 0.491652699810336 no 1647 0.49284798009736 2347 91467 include heat shock SGTC_448 monastrol 171 µM 0.0174488578759523 0.491855509623588 no 1648 0.493039266064266 2333 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity SGTC_2881 9058953 51.95 µM 0.0172422824139347 0.491942873107947 no 1649 0.493121665353391 2361 17122249 SGTC_1153 4055-0057 267 µM 0.0168451126673811 0.492110842508429 no 1650 0.493280090144855 2365 882706 SGTC_3334 9142812 21.919 µM 0.0162013697941158 0.492383094562615 no 1651 0.493536871335002 2343 45283678 SGTC_2040 5100729 123 µM 0.0139687413164457 0.493327345586516 no 1652 0.494427459709804 2374 11840 YJR013W | YDR381W GPI14 | YRA1 SGTC_2581 avocatin a 64 µM 0.0131194828769872 0.493686534639024 no 1653 0.494766233723831 2372 6710728 A skin care supplement. SGTC_2810 7959871 45.46 µM 0.0119442742314591 0.494183590868607 no 1654 0.495235037300077 2378 2974535 SGTC_275 trichlorophene 5.69 µM 0.0110388580765596 0.494566544165533 no 1655 0.495596222224166 2346 62616 SGTC_1204 4049-0315 18.3 µM 0.010859666359092 0.494642335398292 no 1656 0.495667705091428 2377 588402 SGTC_3068 9116768 49.47 µM 0.0107767101983834 0.494677422742388 no 1657 0.495700797874811 2369 41904888 SGTC_983 1491-0821 12.2 µM 0.00969596683756542 0.495134540305945 no 1658 0.496131929486581 2383 46495113 SGTC_2949 9072542 2.23 µM 0.00924855453232315 0.495323782348242 no 1659 0.496310413163136 2376 16457352 SGTC_400 oxethazaine 37.5 µM 0.00880369016455688 0.495511947732524 no 1660 0.496487881137635 2339 4621 A local anesthetic. SGTC_2873 9040596 71.43 µM 0.00517682508699867 0.497046045374852 no 1661 0.497934754819153 2361 6463863 SGTC_857 0438-0306 1.35 µM 0.00507984566755858 0.497087066597533 no 1662 0.497973443501126 2367 4686136 SGTC_1102 cgs 12066b 26.1 µM 0.00415501210227525 0.497478262460446 no 1663 0.498342394766342 2374 6438352 A 5-HT1B full agonist. SGTC_1324 1418-0026 34.4 µM 0.00415274538053283 0.497479221265466 no 1664 0.498343299049681 2361 1372513 SGTC_1973 st070275 50.2 µM 0.00274578283381647 0.49807435766684 no 1665 0.498904592511229 2403 17118334 SGTC_2239 6685329 187.64 µM 0.00188946614534002 0.498436576479428 no 1666 0.499246212515751 2366 805680 SGTC_2027 5150920 200 µM 0.00105027654763267 0.498791551847935 no 1667 0.499581000356067 2400 786715 SGTC_2395 5646831 180.19 µM 0.000657191318868498 0.49895782638806 no 1668 0.499737818615463 2403 6808628 SGTC_1801 st050089 28.441 µM 0.000305653494015201 0.49910652658462 no 1669 0.499878061899984 2394 5008493 YIL048W | YNL267W NEO1 | PIK1 SGTC_2397 5161689 200 µM -0.000284215235869749 0.499356040816753 no 1670 0.499886614527204 2406 2259942 SGTC_442 cape 100 µM -0.000298654879589643 0.499362148783713 no 1671 0.499880853943055 2407 5281787 SGTC_1011 4112-3381 17.4 µM -0.000368791467822152 0.499391816551303 no 1672 0.499852873494169 2409 2877139 SGTC_2583 asiatic acid 100 µM -0.000644784535333231 0.499508561613629 no 1673 0.49974276820493 2410 5320556 A kinase inhibitor; arrests cells at G2/M. SGTC_1029 k015-0030 64.7 µM -0.000845934411362924 0.49959364803446 no 1674 0.499662521037111 2412 2208316 SGTC_445 e6 berbamine 66 µM -0.00114728005557847 0.499721117310211 no 1675 0.499542301578776 2407 6610268 A calcium/calmodulin antagonist. SGTC_2560 caryophyllene 100 µM -0.00171025150864264 0.499959254428547 no 1676 0.499317708695695 2407 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor. SGTC_721 1187-1332 279 µM -0.00190290179000985 0.499959254428547 no 1677 0.499240852478664 2409 25730 SGTC_2732 terfenadine 20 µM -0.00285535287403072 0.499556367345369 no 1678 0.498860880560965 2411 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.  SGTC_619 1652-1634 108 µM -0.00315412314072846 0.499429987510262 no 1679 0.498741689007954 2409 5400454 SGTC_695 3505-6186 243 µM -0.00348558793376262 0.499289777956645 no 1680 0.498609454416864 2414 1819379 SGTC_543 3844-1095 191 µM -0.00441148367897825 0.498898124726434 no 1681 0.498240078349518 2418 4230703 SGTC_1932 st074806 40.9 µM -0.00455006266138614 0.49883950599932 no 1682 0.498184793889289 2460 17251235 SGTC_3314 9135860 59.4275 µM -0.00479265998230881 0.498736887713043 no 1683 0.498088012617066 2411 25252478 SGTC_2045 5106652 78.05 µM -0.0050850467502186 0.498613208680459 no 1684 0.497971368596148 2411 673349 SGTC_2555 cholic acid 100 µM -0.00531160948369732 0.498517373177103 no 1685 0.49788098436401 2450 6708657 Influences liver metabolism. SGTC_299 1273-0059 1.44 µM -0.00535830567594619 0.49849762080807 no 1686 0.497862355543697 2411 2848077 SGTC_2446 5162541 200 µM -0.00537406223332366 0.498490955825717 no 1687 0.49785606967727 2418 1549321 SGTC_1043 0916-0009 19.3 µM -0.0053781697708362 0.498489218348215 no 1688 0.497854431030568 2411 3101130 SGTC_972 1319-0219 195 µM -0.00568926567768596 0.498357625688251 no 1689 0.497730323620792 2416 23903702 SGTC_69 0096-0274 206.684 µM -0.00595618285591573 0.498244720643353 no 1690 0.497623840878463 2473 6741392 SGTC_356 1634-0012 32.5 µM -0.006330324571783 0.4980864602279 no 1691 0.497474582746508 2416 735457 SGTC_3028 9087778 49.47 µM -0.00671739981143814 0.497922729302024 no 1692 0.497320165354774 2419 17217395 SGTC_998 3996-0085 177 µM -0.00671744058431457 0.497922712055316 no 1693 0.497320149089117 2420 715391 SGTC_2580 diallyl disulphide 81.36 µM -0.00683412767883517 0.497873354054645 no 1694 0.497273598742166 2427 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.  SGTC_49 0717-0965 32.132 µM -0.00684781992311131 0.497867562312571 no 1695 0.497268136454827 2475 5889349 YGL099W LSG1 SGTC_1516 st013856 110 µM -0.00710980652286416 0.497756743547056 no 1696 0.497163621468757 2463 5281404 A mutagen and neurotoxin. SGTC_2325 6158266 200 µM -0.00810424585661713 0.49733610330177 no 1697 0.496766909067989 2438 3623240 SGTC_1526 st051518 75 µM -0.00815864890714483 0.497313091307975 no 1698 0.496745206108469 2442 673993 SGTC_1779 st039427 55 µM -0.00942093251807326 0.49677915953173 no 1699 0.496241647292601 2424 1124498 SGTC_2884 9058502 51.95 µM -0.0100003452816348 0.496534076320976 no 1700 0.496010505944813 2432 6471554 SGTC_474 dl-dihydrosphingosine 5 µM -0.0104158508800847 0.496358324268175 no 1701 0.495844751831491 2470 3058739 A sphingolipid protein kinase C inhibitor. SGTC_1202 1988-0068 29.6 µM -0.0105502504928119 0.496301475586127 no 1702 0.495791137089604 2427 2850480 SGTC_677 0929-0063 136 µM -0.0107310566590435 0.496224997863494 no 1703 0.495719009948795 2432 1539583 SGTC_2808 7946468 45.46 µM -0.0112124915891992 0.496021360320998 no 1704 0.495526956761761 2429 2970879 SGTC_2387 9077560 195.08 µM -0.0119038751085326 0.495728920465815 no 1705 0.495251153072563 2422 5303272 SGTC_1434 4073-0095 163 µM -0.0135831166344484 0.495018648508484 no 1706 0.494581287101784 2433 24133745 SGTC_2824 7998404 51.95 µM -0.0148649486474624 0.494476480110922 no 1707 0.494069961879493 2436 837851 SGTC_218 alverine citrate 93.75 µM -0.0160170966215026 0.49398917203066 no 1708 0.493610376156456 2431 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_2753 fluvastatin 17.09 µM -0.0162655681461042 0.493884080620175 no 1709 0.493511263272478 2456 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5 SGTC_266 formosanin C 406 nM -0.0163248591012365 0.493859003482681 no 1710 0.493487612743852 2440 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1 SGTC_3308 9128332 17.569 µM -0.0170380180825584 0.493557374484523 no 1711 0.49320314306208 2442 17332805 YDL196W YDL196W SGTC_1870 st057514 26.5 µM -0.0187519572773477 0.492832483124329 no 1712 0.492519489807012 2437 5393161 SGTC_1571 st070080 73.4 µM -0.0191344980654434 0.492670694934587 no 1713 0.492366905493174 2448 4315245 SGTC_1122 capsaicin 818.572 nM -0.0196337948747216 0.492459528873306 no 1714 0.492167752306487 2484 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_3014 9081533 49.47 µM -0.020091079811173 0.492266132616415 no 1715 0.491985357995059 2454 21367265 SGTC_2381 9035592 200 µM -0.0203805008428362 0.49214373078013 no 1716 0.491869919346839 2472 4749657 SGTC_2367 9070478 135.38 µM -0.0206586489790391 0.492026097169593 no 1717 0.491758977654073 2450 572802 SGTC_2738 aclarubicin 5.55 µM -0.0208729655405271 0.491935459497703 no 1718 0.491673496149069 2453 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31 SGTC_359 0081-0058 15.9 µM -0.0218545727011741 0.491520328574249 no 1719 0.491281980921709 2458 3494159 SGTC_1129 3453-1384 223 µM -0.0218893185223373 0.491505634404528 no 1720 0.491268122659748 2527 1084452 SGTC_1358 1509-0022 2.48 µM -0.0226135650569223 0.491199349823685 no 1721 0.490979261622233 2469 3258434 SGTC_2844 9010103 25.97 µM -0.0234742983082943 0.490835351637005 no 1722 0.490635969906671 2500 2480525 SGTC_1398 3558-0053 112 µM -0.0238003508252048 0.490697468241308 no 1723 0.490505930105816 2457 4532369 SGTC_1443 4112-3303 14 µM -0.0255598833255144 0.489953404288398 no 1724 0.489804192037943 2455 704433 SGTC_2477 5967686 25.23 µM -0.0258099006710412 0.489847680746139 no 1725 0.489704482443555 2455 776118 SGTC_336 4111-0029 111 µM -0.0260459329154887 0.489747871665708 no 1726 0.489610350847549 2486 3131175 SGTC_696 1560-0013 611 µM -0.0260811720690269 0.489732970419678 no 1727 0.48959629723346 2479 1650269 SGTC_2964 9083345 53.42 µM -0.0263458888157014 0.489621032623839 no 1728 0.489490726808737 2473 17741579 SGTC_1906 st060206 94.7 µM -0.026664903123842 0.489486135715369 no 1729 0.489363503211135 2444 5133468 SGTC_2940 9060638 45.86 µM -0.027227651415856 0.489248177528202 no 1730 0.48913908061881 2482 4027022 SGTC_1868 st057644 42.7 µM -0.0276266101008211 0.489079480110673 no 1731 0.488979978985457 2459 688665 SGTC_156 3474-0145 5.642 µM -0.0284606866698242 0.488726801910485 no 1732 0.488647361405265 2438 2265471 SGTC_1039 k821-0043 94 µM -0.0311788551449226 0.487577523080209 no 1733 0.487563451432505 2436 15992768 SGTC_2673 kobusone 100 µM -0.0312424751324966 0.487550624877045 no 1734 0.487538083088321 2475 6710676 An epoxy ketone and protein crosslinker. SGTC_2831 7999036 19.48 µM -0.0325275869431184 0.487007298513808 no 1735 0.487025658233178 2501 2988270 SGTC_1271 0832-2808 169 µM -0.0334450699064439 0.486619414912794 no 1736 0.4866598345805 2477 3663794 SGTC_629 3448-6466 76.7 µM -0.034058266096175 0.486360181442897 no 1737 0.486415343996523 2469 573744 SGTC_1814 st052110 31.539 µM -0.0340594192351915 0.486359693949783 no 1738 0.486414884227359 2477 674163 SGTC_1573 oleylamine 1.06 µM -0.0348240690228986 0.486036440391699 no 1739 0.486110013982086 2463 5356789 An amine of the fatty acid oleic acid. SGTC_2008 4012253 172 µM -0.0371364171627067 0.485058958382452 no 1740 0.485188117673826 2491 603940 SGTC_1262 0737-0114 49.6 µM -0.0372846267558258 0.484996309824598 no 1741 0.485129031521008 2470 765919 SGTC_1257 0669-0121 16 µM -0.0375343902618524 0.484890735017864 no 1742 0.485029459996741 2518 4307855 SGTC_2357 9067248 200 µM -0.0385508111585606 0.484461105833117 no 1743 0.484624260060572 2499 9150235 SGTC_899 1083-0020 478 µM -0.0387031656994717 0.484396708899074 no 1744 0.484563524719463 2537 767123 SGTC_3220 9131269 49.47 µM -0.0390533519526297 0.48424869437028 no 1745 0.484423926160591 2471 17722206 SGTC_595 3909-8003 73.7 µM -0.0392005402022365 0.484186482410918 no 1746 0.484365251474955 2504 699517 SGTC_1869 3',7'-dimethoxyflavone 40.3 µM -0.0404195054025966 0.483671278138511 no 1747 0.483879339946359 2476 688664 SGTC_2939 9044578 71.43 µM -0.0407577868479337 0.483528305886422 no 1748 0.483744496294831 2488 2653634 SGTC_2540 epiandrosterone 100 µM -0.041064757731612 0.483398568653462 no 1749 0.483622135073777 2489 441302 A steroid. SGTC_2208 7283366 200 µM -0.0413014393437 0.483298539462077 no 1750 0.483527792810359 2485 898663 SGTC_1120 ficusin 1.78878 µM -0.0431056628507619 0.482536052120476 no 1751 0.482808652597417 2586 6199 A DNA cross-linker. SGTC_2061 5245884 80.95 µM -0.0431852746009517 0.482502408653488 no 1752 0.482776921652083 2494 573863 SGTC_2311 7694451 200 µM -0.0434014558933467 0.482411052313974 no 1753 0.482690758580721 2523 2163142 SGTC_3214 9129694 49.47 µM -0.043872859152808 0.482211844593558 no 1754 0.482502874860558 2486 17158655 SGTC_424 splitomicin 100 mM -0.0443431915275048 0.482013093838396 no 1755 0.48231542182751 2564 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_1343 1487-0095 224 µM -0.0447461440041721 0.481842819704728 no 1756 0.482154826456592 2480 4560101 YGL055W OLE1 SGTC_35 0133-0054 64.071 µM -0.0450751946697366 0.481703776440617 no 1757 0.482023686553513 2523 99677 SGTC_819 1013-0258 27.7 µM -0.0467783663909721 0.480984122140063 no 1758 0.481344935636876 2487 5753198 SGTC_2869 9037858 32.47 µM -0.0471670760423184 0.480819886249961 no 1759 0.481190033907845 2481 27187042 SGTC_1636 st007707 68.9 µM -0.0472482112436197 0.480785605771768 no 1760 0.481157701692872 2513 403051 SGTC_136 0097-0015 404.482 µM -0.0485001568810671 0.480256663703481 no 1761 0.480658819708739 2476 4861337 SGTC_2348 9022543 33.42 µM -0.0491263295000409 0.4799921212375 no 1762 0.480409310414392 2533 3162678 YDL140C RPO21 SGTC_436 n,n-dimethylsphingosine 3.3 µM -0.049482110984556 0.479841816266039 no 1763 0.480267546550463 2595 5282309 SGTC_590 k048-0076 22.4 µM -0.0525756234576883 0.478535040836342 no 1764 0.479035019881909 2528 6832814 SGTC_2788 5282734 71.43 µM -0.0534448867810615 0.478167883638693 no 1765 0.478688720907432 2546 743706 SGTC_1833 st055984 71 µM -0.0536859195463632 0.478066080109501 no 1766 0.478592700598734 2532 676288 SGTC_665 3914-0008 307 µM -0.0540968463505585 0.477892522781659 no 1767 0.478429002409004 2509 1069549 SGTC_1287 0971-0001 34.6 µM -0.055784612566297 0.477179729225456 no 1768 0.477756696623911 2496 4665869 SGTC_3251 9135047 49.47 µM -0.058502079074109 0.476032217169175 no 1769 0.476674353235683 2594 17682963 SGTC_61 0978-8327 98.565 µM -0.0595497799912329 0.475589854185284 no 1770 0.476257108547982 2518 6150059 YHR072W ERG7 SGTC_1319 1306-0155 43.7 µM -0.0599012304752018 0.475441470567233 no 1771 0.476117149939616 2516 3122360 SGTC_19 0279-0214 38.434 µM -0.0602272738967182 0.47530381694452 no 1772 0.475987311854831 2527 3566274 YBR002C RER2 SGTC_226 1,3-diallylurea 8.28947 mM -0.0610286302469933 0.474965501547254 no 1773 0.475668203953037 2596 74537 YKL182W FAS1 SGTC_2919 7978188 46.38 µM -0.0612486869426369 0.474872601496944 no 1774 0.475580577956537 2510 2980291 SGTC_2750 bromebric acid 70.15 µM -0.0616519460834742 0.474702363489331 no 1775 0.475420004297193 2575 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2 SGTC_3075 9116269 49.47 µM -0.0616806568874219 0.474690243245327 no 1776 0.475408572101066 2581 17015205 YNL244C SUI1 SGTC_1714 st033236 13.627 µM -0.0627533822729997 0.47423740992601 no 1777 0.474981444107643 2574 2916566 SGTC_1293 1000-1278 195 µM -0.0628654226426895 0.474190115842456 no 1778 0.474936834546754 2565 678847 SGTC_3279 9140807 49.47 µM -0.0630144871302706 0.474127193833557 no 1779 0.474877484093275 2508 45595718 SGTC_1217 1183-1422 255 µM -0.0649372296681613 0.473315638257308 no 1780 0.474111989073576 2582 2849664 SGTC_2355 9061122 103.12 µM -0.0664263972351255 0.472687162924096 no 1781 0.473519177328057 2569 5302957 SGTC_1169 aniline yellow 25.8 µM -0.0670733812288642 0.472414136518373 no 1782 0.473261642431747 2559 6051 A DNA damaging agent. SGTC_1407 3909-7909 12.3 µM -0.0671223963066993 0.472393452745688 no 1783 0.473242132213031 2537 4411780 SGTC_70 0141-0289 43.283 µM -0.0673458741120869 0.472299148746908 no 1784 0.473153178749205 2640 352408 SGTC_3051 9093778 49.47 µM -0.0690902487305227 0.471563104807849 no 1785 0.472458891433645 2530 17217378 SGTC_1824 st053723 68.6 µM -0.0715254712081585 0.470535718583813 no 1786 0.47148977668817 2563 675225 SGTC_11 0438-0307 1.3 µM -0.0718235959436909 0.47040995727227 no 1787 0.471371147232373 2584 4011476 SGTC_2372 9071633 200 µM -0.0739513397648037 0.46951247359511 no 1788 0.47052455221207 2530 21321366 SGTC_2312 7706453 155.7 µM -0.0743700403855399 0.469335883504324 no 1789 0.470357973538607 2561 976098 SGTC_2842 9000675 19.48 µM -0.0748899746606945 0.469116605768746 no 1790 0.470151126609618 2610 2989072 SGTC_2308 7584454 197.62 µM -0.0749080434447671 0.46910898558505 no 1791 0.470143938398434 2561 893577 SGTC_3140 9094243 49.47 µM -0.0758552513656535 0.468709533645063 no 1792 0.469767129235656 2539 19291112 SGTC_379 3970-0972 5.9 µM -0.075957233961634 0.468666527909325 no 1793 0.469726561106645 2583 2898042 YBL034C STU1 SGTC_3200 9114385 49.47 µM -0.0769639076052713 0.468242036537951 no 1794 0.469326128664772 2598 17018030 YLR208W SEC13 SGTC_1222 0366-0074 1.18 µM -0.0771334077485735 0.46817056572239 no 1795 0.469258708308778 2589 286520 SGTC_1125 tnp00248 1.32998 µM -0.0773802056701173 0.468066503641028 no 1796 0.469160543574686 2611 24207736 SGTC_777 1315-0167 517 µM -0.0777849633461413 0.467895842724148 no 1797 0.468999553858467 2619 4221767 SGTC_2255 7941087 197.44 µM -0.0779027046952186 0.467846199690939 no 1798 0.468952723958054 2532 935561 SGTC_1813 st051246 8.6015 µM -0.0784262646965133 0.467625458273474 no 1799 0.468744490831773 2561 5291959 SGTC_2746 daunorubicin 9.88 µM -0.0786164489576497 0.46754527595507 no 1800 0.468668851828895 2519 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_501 nsc-95397 161 µM -0.0790516269385551 0.46736180842695 no 1801 0.468495779575827 2682 262093 SGTC_1031 k035-0009 16 µM -0.0806159482682221 0.466702360701451 no 1802 0.467873691301746 2645 5180959 SGTC_840 0245-0196 390 µM -0.080741771061089 0.466649323401267 no 1803 0.467823658369268 2668 3827528 SGTC_404 fumagillin 50 µM -0.0816020551911066 0.466286709092186 no 1804 0.467481583470666 2580 12015870 A methionine aminopeptidase binder. SGTC_1330 1469-0054 61.8 µM -0.082058907157717 0.4660941549302 no 1805 0.467299935105542 2612 7102664 SGTC_953 1188-0045 9.7 µM -0.0827458869459679 0.465804621350296 no 1806 0.467026798722717 2641 6144426 SGTC_2710 st078562 53.7235 µM -0.0848930269286625 0.464899807994063 no 1807 0.466173217740419 2532 17250908 SGTC_1633 st005664 67.9 µM -0.0852804964497236 0.464736545983456 no 1808 0.466019198309008 2555 2063822 SGTC_1551 6-bromo-3'-methylflavone 63.5 µM -0.0858214831627964 0.464508608755904 no 1809 0.465804164194565 2660 688751 SGTC_2449 5812982 45.77 µM -0.0861136354918633 0.464385519273737 no 1810 0.465688042167718 2539 776185 SGTC_3096 9117468 49.47 µM -0.0871941289335848 0.463930315988474 no 1811 0.465258603008226 2555 41316311 SGTC_1520 flindersine 88 µM -0.0878970901465755 0.463634189338738 no 1812 0.464979234690557 2798 68230 Flindersine is a natural alkaloid of the quinoline subtype. SGTC_262 fenpropimorph 62.5 µM -0.0881890305028226 0.463511213614925 no 1813 0.464863217868884 2554 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_2817 7995342 71.43 µM -0.088298654842306 0.463465036820503 no 1814 0.464819654030827 2563 18879975 SGTC_1736 st036774 51 µM -0.0895620444911489 0.462932897947083 no 1815 0.464317623627324 2713 1272247 SGTC_1210 3013-0140 750 nM -0.089754705551321 0.462851755042382 no 1816 0.464241071291658 2657 905973 SGTC_2168 5727979 200 µM -0.0903689461540101 0.462593066154872 no 1817 0.463997016538719 2548 695210 SGTC_2048 5246248 200 µM -0.0909100359924222 0.462365197988121 no 1818 0.463782037824198 2592 677046 SGTC_313 3474-0040 5.03 µM -0.0920740406770856 0.461875044799623 no 1819 0.463319606680591 2550 1043375 YIL048W NEO1 SGTC_2284 7945075 39.21 µM -0.092154019785647 0.461841368345343 no 1820 0.463287834711471 2646 1245402 SGTC_2893 9048488 25.97 µM -0.092636238493579 0.461638328423853 no 1821 0.463096276681885 2604 6467338 SGTC_3100 9120536 49.47 µM -0.0929906672999596 0.461489101271768 no 1822 0.462955487755805 2543 16421196 SGTC_1748 st037455 53.6035 µM -0.0931374962745991 0.461427282630573 no 1823 0.462897164583801 2666 580690 SGTC_44 0929-0055 61.211 µM -0.0933819992480536 0.461324342881441 no 1824 0.462800045271704 2573 1379590 SGTC_1314 1222-0010 41.1 µM -0.0934352431754931 0.461301926660857 no 1825 0.462778896482818 2623 3526027 SGTC_462 ag-879 158 µM -0.0943948123367492 0.46089795968736 no 1826 0.462397768281123 2573 6809654 Ag-879 is a 5-Lipoxygenase inhibitor. SGTC_1563 conessine 56.1 µM -0.0953421443102793 0.46049918399874 no 1827 0.462021534390233 2631 441082 An anti-amoebic, histamine inhibitor. SGTC_2231 micatex 6.853 µM -0.0956358225327175 0.460375569347203 no 1828 0.46190490665913 2596 20737 An antifungal of unknown mechanism. SGTC_876 0720-0963 56.8 µM -0.0959263553042001 0.460253282442839 no 1829 0.46178953129656 2651 765861 SGTC_2768 sulfasalazine 50.2 µM -0.0961606951671513 0.460154650193357 no 1830 0.461696473408425 2588 5384001 An antioxidant and salicylic acid derivative. SGTC_2002 4023503 131 µM -0.0962107696908609 0.460133574442958 no 1831 0.461676588760179 2569 4736863 YCR052W RSC6 SGTC_1683 st010134 710 nM -0.0963794230304084 0.460062591153446 no 1832 0.461609617039171 2570 3818134 SGTC_604 1000-0114 314 µM -0.0984649305636535 0.459184942794622 no 1833 0.46078155897904 2617 1572745 SGTC_3280 9140961 49.47 µM -0.0993869172701298 0.458797004405705 no 1834 0.46041553491945 2570 4901226 SGTC_563 tetrahydrosecaminediol 614 µM -0.0995737147944013 0.458718411586565 no 1835 0.460341381322904 2658 334274 A psychoactive constituent of the cannabis plant. SGTC_2280 7785178 200 µM -0.100081130873807 0.45850493050747 no 1836 0.460139957746611 2603 2954328 SGTC_2071 5230951 39.92 µM -0.100825675945328 0.458191705739115 no 1837 0.459844422120885 2583 1799272 SGTC_745 0469-0705 296 µM -0.100871568608331 0.458172399872556 no 1838 0.459826206463844 2643 3486736 SGTC_1621 st003705 32.4 µM -0.101140071346736 0.458059449634363 no 1839 0.459719634391831 2611 24207032 SGTC_3141 9094609 49.47 µM -0.101704341443697 0.457822090880725 no 1840 0.459495678022328 2583 25236309 YDL196W YDL196W SGTC_2757 clomiphene 4.22 µM -0.102322313693495 0.457562159715826 no 1841 0.459250422247527 2662 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined. SGTC_719 2810-4230 27.3 µM -0.102445948916176 0.457510158508507 no 1842 0.459201356769686 2591 721079 SGTC_2594 a-mangostin 100 µM -0.103325656954367 0.457140172705941 no 1843 0.458852256646035 2713 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis. SGTC_3231 9132313 49.47 µM -0.104030859869206 0.45684360671903 no 1844 0.45857242939854 2633 4905967 SGTC_485 niflumic acid 177 µM -0.104782172882587 0.456527676041306 no 1845 0.458274328074111 2716 4488 A COX2 inhibitor. SGTC_1261 0712-0010 12.7 µM -0.105806458618586 0.456097003347881 no 1846 0.457867956160837 2636 2840123 SGTC_2709 st078560 56 µM -0.106891089743065 0.455641013975981 no 1847 0.457437691023048 2639 17250903 SGTC_720 r052-1644 49.9 µM -0.107940686968985 0.455199808812456 no 1848 0.457021371058535 2683 1422863 YOR257W CDC31 SGTC_463 ikarugamyin 104 µM -0.108716079704954 0.454873902783084 no 1849 0.456713843845869 2598 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis. SGTC_2516 gossypol 71.55 µM -0.108963088363273 0.454770088716522 no 1850 0.456615883591701 2692 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_613 3914-0030 117 µM -0.109014719633299 0.454748389251495 no 1851 0.456595407669414 2556 1145395 SGTC_2730 imipramine 71.33 µM -0.109056633665574 0.454730773822901 no 1852 0.45657878549275 2616 3696 A tricyclic antidepressant. SGTC_762 1165-0429 115 µM -0.110796706190316 0.453999543457243 no 1853 0.455888778675231 2620 5967793 SGTC_281 1672-3440 14.9 µM -0.111709751401756 0.453615916836078 no 1854 0.455526773614717 2686 6833000 SGTC_1704 st028805 70.8 µM -0.11307583662896 0.453042021077609 no 1855 0.454985215842524 2632 2876101 SGTC_1903 st060211 78.3 µM -0.113078843109065 0.453040758155646 no 1856 0.454984024074166 2678 688960 SGTC_726 3448-4391 34.2 µM -0.113512154270426 0.452858743570601 no 1857 0.454812263823762 2733 1356692 SGTC_1544 7-methoxy-4-methylcoumarin 105 µM -0.113861620968063 0.452711955497739 no 1858 0.454673744840574 2653 390807 SGTC_2468 5987765 72.9 µM -0.113948256626676 0.452675566530208 no 1859 0.454639405701241 2681 26772094 SGTC_723 4182-0001 115 µM -0.11400779028204 0.452650561257238 no 1860 0.454615808980263 2636 744821 YLR208W SEC13 SGTC_3300 9124615 50.48 µM -0.116895505809011 0.451437892876298 no 1861 0.453471429791334 2775 24824903 SGTC_1971 st069429 63.5 µM -0.1170990694133 0.451352425258935 no 1862 0.453390773582198 2662 1246522 YGL099W LSG1 SGTC_2081 5214970 32.255 µM -0.117167525621122 0.451323683942957 no 1863 0.453363650215372 2634 2063512 SGTC_286 k060-0067 22.9 µM -0.118424746703099 0.45079588562189 no 1864 0.452865559355075 2640 5985051 SGTC_2207 7258803 200 µM -0.11855868892572 0.450739659986563 no 1865 0.452812497948634 2643 3666799 SGTC_1739 st037196 92.5 µM -0.118641218688916 0.450705016523401 no 1866 0.452779804082305 2672 612214 SGTC_872 0588-0139 234 µM -0.118729948797055 0.450667770764548 no 1867 0.45274465432892 2637 2047100 SGTC_863 0466-0191 129 µM -0.119835782698613 0.45020361738176 no 1868 0.452306617843515 2614 765160 YPR165W RHO1 SGTC_3095 9117207 49.47 µM -0.120373943136095 0.4499777590619 no 1869 0.452093465829391 2681 17015229 SGTC_1130 3454-2858 15.9 µM -0.120379046223528 0.44997561744575 no 1870 0.452091444688899 2740 715628 YIL048W NEO1 SGTC_1132 3456-3614 2.5 µM -0.121186216694586 0.449636890049329 no 1871 0.451771770568085 2859 3125502 SGTC_2722 naftopidil 47.16 µM -0.121825336884727 0.449368710618287 no 1872 0.451518673736053 2606 4418 An a1-adrenergic receptor antagonist or alpha blocker.  SGTC_2294 7971431 200 µM -0.122195666752735 0.449213328115175 no 1873 0.451372029084562 2726 5741572 SGTC_553 k007-0256 45.7 µM -0.122864393788871 0.448932764278705 no 1874 0.451107240793931 2679 6287000 SGTC_1173 0443-0020 122 µM -0.124956570364553 0.448055158988776 no 1875 0.450278966302985 2655 5331295 SGTC_483 fpl-64176 144 µM -0.125851099080725 0.447680008358241 no 1876 0.449924896039247 2635 3423 SGTC_1448 4255-0083 152 µM -0.126888866035453 0.447244844624901 no 1877 0.449514179512264 2793 5399660 SGTC_1656 st012921 11 µM -0.127307122759259 0.447069476200602 no 1878 0.449348661516388 2730 6732821 SGTC_1197 1601-0112 267 µM -0.128096111028374 0.446738694107745 no 1879 0.449036456822609 2629 7350313 SGTC_3041 9091929 49.47 µM -0.128246768578156 0.446675535372701 no 1880 0.448976844823215 2751 25236887 SGTC_102 gallobenzophenone 83.616 µM -0.128250203121449 0.446674095557469 no 1881 0.448975485860649 2751 70837 SGTC_310 1273-0058 1.06 µM -0.128295946180844 0.446654919405698 no 1882 0.448957386537384 2669 2734232 SGTC_381 3461-2219 42.7 µM -0.129208796332674 0.446272265566998 no 1883 0.448596218045495 2701 2883159 SGTC_2704 st078022 71.1 µM -0.130028437201425 0.445928726354422 no 1884 0.448271964023941 2752 54697681 SGTC_169 k015-0017 16.025 µM -0.130308185851303 0.445811483510438 no 1885 0.44816130195984 2708 1840002 SGTC_535 2293-4129 48.2 µM -0.130749418481139 0.445626572258057 no 1886 0.447986768788645 2724 396118 YIL048W NEO1 SGTC_881 0833-0569 170 µM -0.133289505245234 0.444562306925117 no 1887 0.446982213572015 2651 5418700 SGTC_2431 5490079 200 µM -0.13418298768664 0.444188043289578 no 1888 0.446628939054313 2686 5722345 SGTC_1417 3966-0327 90.4 µM -0.134433514983965 0.444083110854326 no 1889 0.446529890517881 2676 651118 SGTC_1677 st019204 53.9 µM -0.137399152741057 0.442841264228544 no 1890 0.445357650355744 2770 3945625 SGTC_410 α-linolenic acid 100 µM -0.137567458569957 0.442770803685333 no 1891 0.445291137624903 2767 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_540 1187-0821 17.3 µM -0.13817492782927 0.442516504249603 no 1892 0.445051084850927 2661 847520 SGTC_126 0417-1624 672.48 µM -0.140143721991296 0.441692488802527 no 1893 0.444273218142641 2652 41912 YDL195W SEC31 SGTC_183 3914-0051 30.55 µM -0.140911198655007 0.441371338691576 no 1894 0.443970047588351 2732 1596232 SGTC_1469 k284-2957 126 µM -0.141413061417835 0.441161355374413 no 1895 0.443771818220341 2686 23884841 SGTC_624 k048-0052 28 µM -0.142107379068324 0.440870874704004 no 1896 0.443497594839574 2725 6835531 SGTC_2970 9090938 41.86 µM -0.142160484508877 0.44084865836534 no 1897 0.443476621757259 2772 17217104 SGTC_1559 coumarin 343 70.1 µM -0.142323278435268 0.440780555674868 no 1898 0.443412330076901 2785 108770 A hepatotoxic, DNA x-linker. SGTC_1148 3909-7663 27.7 µM -0.142943195510807 0.440521237598281 no 1899 0.443167521875892 2813 4084526 SGTC_181 1447-1644 8.07 µM -0.144864641404201 0.439717638351155 no 1900 0.442408871981809 2696 534600 SGTC_969 1313-0238 134 µM -0.145018935401716 0.439653119266741 no 1901 0.44234796076986 2678 5212874 SGTC_1560 lithocholic acid 53.1 µM -0.145097912331027 0.439620095146685 no 1902 0.442316783282694 2657 9903 A bile acid which acts as a detergent. SGTC_3336 9143619 71.43 µM -0.147973409426668 0.438417997009728 no 1903 0.441181876699655 2656 45595730 SGTC_1474 0330-0125 5.35 µM -0.148468236358997 0.438211192166697 no 1904 0.440986625912464 2699 X1474 SGTC_1381 2324-0066 62.1 µM -0.150110237460557 0.437525065791125 no 1905 0.440338821589699 2789 10885928 SGTC_2938 9059746 27.26 µM -0.150166092387611 0.437501729549848 no 1906 0.440316788432296 2782 6471769 SGTC_1401 3807-4679 7.6 µM -0.150778886383411 0.437245717933718 no 1907 0.440075071029472 2664 3291456 SGTC_186 3455-3465 67.277 µM -0.151602383053243 0.436901720852739 no 1908 0.439750276865239 2667 755278 SGTC_569 4130-2812 160 µM -0.151614129817679 0.436896814252446 no 1909 0.439745644133185 2652 743552 SGTC_2305 7443522 69.23 µM -0.151777248975782 0.436828680706076 no 1910 0.439681313454227 2693 5415886 SGTC_970 1315-0089 19.5 µM -0.151784679543385 0.436825577062999 no 1911 0.43967838303649 2661 6811083 YLR033W RSC58 SGTC_2871 9038510 12.99 µM -0.151845127831003 0.43680032881203 no 1912 0.439654543966437 2684 4945164 SGTC_481 bay k-8644 50 µM -0.152805182854673 0.436399364272141 no 1913 0.439275955205703 2674 2303 A calcium channel antagonist. SGTC_1228 0124-0032 52.5 µM -0.153080017612773 0.436284592246761 no 1914 0.439167586887188 2740 X1228 SGTC_2739 tacrine 100.86 µM -0.15336334683878 0.436166278515508 no 1915 0.439055873942667 2765 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders. SGTC_3015 9080845 49.47 µM -0.153589962693632 0.43607165148714 no 1916 0.438966525819362 2796 5296973 SGTC_269 exalamide 29 µM -0.153682521570322 0.4360330031189 no 1917 0.438930033406733 2715 3316 A derivative of salicylamide. SGTC_2015 5119600 184 µM -0.153836851545899 0.435968563313615 no 1918 0.438869188175091 2821 2828786 SGTC_33 0986-0033 35.816 µM -0.155082553845561 0.435448488151755 no 1919 0.43837811789717 2674 2848082 SGTC_2332 7982454 138.89 µM -0.155638649064074 0.435216356860635 no 1920 0.438158929300356 2713 2981748 SGTC_167 3672-0051 66.205 µM -0.155758601089268 0.435166288110993 no 1921 0.438111651903759 2665 3237971 SGTC_701 4424-0219 185 µM -0.155816142208036 0.435142270445444 no 1922 0.438088973197923 2767 2911779 SGTC_2234 tolnaftate 200 µM -0.156625804915688 0.434804342607244 no 1923 0.437769882081157 2709 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7 SGTC_2124 5246320 200 µM -0.157748556869049 0.434335819982845 no 1924 0.437327468316901 2790 579342 SGTC_929 2805-0021 398 µM -0.157868763680378 0.43428566332306 no 1925 0.437280106167839 2785 3098024 SGTC_202 3594-0513 34.79 µM -0.159436433447507 0.433631645462189 no 1926 0.436662518139418 2665 708429 SGTC_1221 2958-7315 257 µM -0.15968214997811 0.433529151138971 no 1927 0.436565731357218 2778 4562705 SGTC_276 colchicine 750 µM -0.159954104974506 0.433415717327093 no 1928 0.436458613773427 2802 2833 A microtubule depolymerizer. SGTC_1340 1486-1359 257 µM -0.16003042984475 0.433383882820861 no 1929 0.436428551784651 2731 4309068 SGTC_2441 5730946 39.09 µM -0.161390718809154 0.432816589621183 no 1930 0.43589283808425 2814 1774275 SGTC_2726 cimetidine 79.27 µM -0.161844198559224 0.432627501706622 no 1931 0.435714273210604 2690 2756 A P450 inhibitor, histamine H2-receptor antagonist. SGTC_124 0136-0217 7.121 µM -0.162346625928831 0.432418022069781 no 1932 0.435516449736795 2744 3976905 SGTC_459 nigericin 15.3 µM -0.162968878425916 0.432158609460845 no 1933 0.435271469232482 2809 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification. SGTC_637 1181-0519 7.26 µM -0.163098077311574 0.432104751033739 no 1934 0.435220606805636 2698 6252091 YGR060W ERG25 SGTC_2966 9084041 48.03 µM -0.163489594541399 0.431941549114102 no 1935 0.435066482640236 2656 17741380 SGTC_1849 st056239 19.2 µM -0.164013503864516 0.43172317841335 no 1936 0.434860256611822 2699 5393181 SGTC_946 3434-1334 87.4 µM -0.165382387542649 0.431152712493976 no 1937 0.43432150774538 2831 4047976 SGTC_3122 9126309 49.47 µM -0.165941626297478 0.430919697671173 no 1938 0.43410144427721 2689 17591206 SGTC_460 trequinsin 123 µM -0.166453927897798 0.430706260985271 no 1939 0.433899868753161 2723 5537 A vasodilator. SGTC_1421 4029-0249 71.4 µM -0.166830114751571 0.430549545732297 no 1940 0.433751861297157 2841 2894095 SGTC_1922 5578187 25 µM -0.167045974168038 0.430459626040799 no 1941 0.433666937474072 2942 1350412 SGTC_1246 0422-0085 105 µM -0.167068979202009 0.430450043138586 no 1942 0.433657886970253 2793 264295 SGTC_2946 9065502 71.43 µM -0.168317184178294 0.429930156477731 no 1943 0.433166877852128 2684 16489101 SGTC_2379 9035213 200 µM -0.16859004063866 0.429816525879041 no 1944 0.433059557422937 2776 646551 SGTC_2417 cerulenin 830 nM -0.168874466515934 0.42969808340533 no 1945 0.432947691743635 2678 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1 SGTC_3169 9102970 49.47 µM -0.169530916265675 0.429424744502146 no 1946 0.4326895283167 2690 17027839 SGTC_1876 myriocin 605 nM -0.171282950826557 0.428695381384281 no 1947 0.432000642813524 2824 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1 SGTC_1453 4237-0541 195 µM -0.17347873125043 0.427781633128267 no 1948 0.431137572206784 2728 739892 SGTC_3289 9119912 71.43 µM -0.173621083872594 0.427722408066769 no 1949 0.431081630571797 2823 17014829 SGTC_844 0330-0132 15.3 µM -0.175744912217752 0.426838994538821 no 1950 0.430247174775012 2831 2828079 SGTC_1716 st033144 30.6155 µM -0.177175005623022 0.426244348780504 no 1951 0.429685463841058 2822 674617 SGTC_1019 4262-0212 3.4 µM -0.177282359246273 0.426199716922081 no 1952 0.429643303299945 2770 4677213 SGTC_2498 4'-Methoxychalcone 54.63 µM -0.178045716113586 0.425882381512535 no 1953 0.429343536503829 2736 641818 YHR062C RPP1 SGTC_321 4534-3890 65.3 µM -0.178233138394166 0.425804475446716 no 1954 0.429269942842887 2840 699746 SGTC_1100 amiodarone 5.07 µM -0.179618701003754 0.425228626854853 no 1955 0.428725961092374 2828 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. SGTC_1531 st059297 52.4 µM -0.179675759811949 0.42520491626367 no 1956 0.42870356229292 2842 7566702 SGTC_2855 9016525 58.44 µM -0.180209974997622 0.424982938118548 no 1957 0.428493863860037 2707 43811474 SGTC_2471 5466956 24.79 µM -0.183267449191 0.423712950084391 no 1958 0.427294086797244 2769 724419 SGTC_1690 st023502 41.2 µM -0.183374750849086 0.423668394328398 no 1959 0.427251992921713 2822 24207482 SGTC_2016 5121758 140 µM -0.1835705618824 0.423587088607416 no 1960 0.427175179419415 2690 2795203 SGTC_1142 3253-1408 9.78 µM -0.184511877960516 0.423196275702376 no 1961 0.426805954932393 2714 256655 SGTC_3319 9138450 16.7555 µM -0.185356536833796 0.422845656964765 no 1962 0.426474698116576 2759 2029690 SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM -0.185394739872481 0.422829800287826 no 1963 0.426459716940837 2861 521171 SGTC_2149 5554786 194.827 µM -0.185755606843566 0.422680023846365 no 1964 0.426318209573977 2744 745063 YPR165W RHO1 SGTC_1439 4092-1168 46 µM -0.185755911776813 0.422679897289723 no 1965 0.426318090004003 2742 2886240 SGTC_3019 9081971 49.47 µM -0.186058021277162 0.422554516511913 no 1966 0.426199630602489 2873 16451803 SGTC_986 1493-0483 84 µM -0.187400125990507 0.421997614376908 no 1967 0.425673461913299 2742 40079 SGTC_1691 st019933 84.6 µM -0.18744179342708 0.421980327095055 no 1968 0.4256571284154 2719 6176082 SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM -0.187849390167392 0.421811228398987 no 1969 0.425497358567331 2795 4330530 SGTC_217 ketoconazole 989 nM -0.188017334946065 0.42174155773748 no 1970 0.425431531097999 2815 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4 SGTC_1297 1068-0111 14.1 µM -0.189068189928249 0.421305673942776 no 1971 0.425019686282763 2724 767057 SGTC_603 3794-0023 45.9 µM -0.189895431859382 0.420962610334763 no 1972 0.424695536094021 2817 3802260 SGTC_133 0724-0033 378.92 µM -0.190308361292996 0.420791387750617 no 1973 0.424533751010448 2702 280309 SGTC_2043 5101342 149 µM -0.190516627720585 0.420705035055198 no 1974 0.424452157382672 2762 678451 SGTC_1442 4112-3290 3 µM -0.191881983264977 0.420139017701381 no 1975 0.423917325237389 2741 704353 SGTC_2766 oltipraz 83.91 µM -0.191889528052341 0.420135890416559 no 1976 0.423914370208862 2883 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40 SGTC_348 k064-0012 10.7 µM -0.192384446395134 0.419930759723959 no 1977 0.423720537409024 2713 5066323 SGTC_2193 5925765 200 µM -0.192655966186305 0.419818231117049 no 1978 0.423614205599737 2872 877370 SGTC_3215 9129942 49.47 µM -0.197472675048244 0.41782309321988 no 1979 0.421728831281669 2850 17682944 SGTC_447 ml7 120 µM -0.197701005700859 0.417728568017732 no 1980 0.421639501405266 2821 4216 Selective myosin light chain kinase inhibitor. SGTC_784 4579-0127 173 µM -0.200041774921188 0.416759802447168 no 1981 0.420723954851422 2966 1948547 SGTC_2513 baicalein 25.65 µM -0.20036998299728 0.416624008432103 no 1982 0.420595616768967 2800 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2 SGTC_3211 9128781 49.47 µM -0.20062316716717 0.41651926188031 no 1983 0.420496620793836 2891 17194361 SGTC_223 busulfan 5 mM -0.200645983834878 0.416509822531966 no 1984 0.420487699636727 2867 2478 A DNA alkylator. SGTC_27 0485-0001 32.618 µM -0.20167017264385 0.416086161115667 no 1985 0.420087291122706 2728 2054479 SGTC_1310 1188-0297 994 nM -0.20377151966274 0.415217232912403 no 1986 0.419266024939418 2816 1588352 SGTC_1928 4'-methoxychalcone 40.3 µM -0.205020706031667 0.414700877916478 no 1987 0.41877797378132 2994 641818 SGTC_1760 st045453 10.4495 µM -0.205102905330453 0.414666905742903 no 1988 0.418745863281756 2856 3323419 YIL048W NEO1 SGTC_3003 9075612 71.4286 µM -0.205190104887247 0.414630867708807 no 1989 0.418711800063096 2836 6501993 SGTC_774 k060-0086 136 µM -0.205722773686092 0.414410740729812 no 1990 0.418503734107897 2750 5911235 SGTC_1914 st062367 72.6 µM -0.205840310093494 0.414362172074422 no 1991 0.418457826237048 2791 978205 SGTC_2299 7976368 114.88 µM -0.207423295015032 0.413708175395705 no 1992 0.417839645697169 2921 2979718 SGTC_740 k014-0057 261 µM -0.209496286102442 0.412852098969325 no 1993 0.417030417163345 2882 4012779 SGTC_289 k017-0060 526 µM -0.210005359277864 0.412641931873139 no 1994 0.416831745104079 2780 5512909 SGTC_1624 st003710 6.25 µM -0.21106528617485 0.412204429305151 no 1995 0.416418163815983 2967 24207033 SGTC_3174 9107204 49.47 µM -0.211867774408833 0.411873261383305 no 1996 0.416105096076362 2900 3938802 SGTC_813 k007-0158 173 µM -0.213189519972969 0.411327945147684 no 1997 0.415589571115272 2859 6523916 SGTC_2763 lisinopril 49.32 µM -0.213748584691754 0.411097341745783 no 1998 0.415371560843768 2793 5362119 A lysine-analog of enalapril and an ACE inhibitor. SGTC_870 0573-2213 57.6 µM -0.215395946922581 0.410418015531899 no 1999 0.414729314868082 2753 3916321 SGTC_2095 5432005 200 µM -0.215772913824534 0.410262602604348 no 2000 0.414582381305674 2801 783734 SGTC_2858 9025781 8.96 µM -0.2160845331968 0.410134141277113 no 2001 0.414460927822069 2894 4894980 YPL153C RAD53 SGTC_605 1315-0399 119 µM -0.216680351257561 0.409888549325476 no 2002 0.414228730827632 2906 24020461 SGTC_1014 4130-3005 69.3 µM -0.218436861785496 0.409164734274316 no 2003 0.413544373673797 2781 743608 SGTC_2175 5807670 165.306 µM -0.218786201335521 0.409020816816638 no 2004 0.413408298111983 2897 241186 SGTC_915 methyl methanesulfonate (MMS) 110 mM -0.219726050007278 0.408633688174868 no 2005 0.413042257722077 2872 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks. SGTC_3298 9116858 71.43 µM -0.221219287683572 0.408018799119792 no 2006 0.412460845936943 2939 2506942 SGTC_2854 9024559 71.43 µM -0.222740178245276 0.407392755878611 no 2007 0.411868864538779 2884 3163529 SGTC_693 4161-2696 114 µM -0.222846642536605 0.407348940885671 no 2008 0.411827432575173 2905 805759 SGTC_2029 5175081 200 µM -0.224101102916054 0.406832759707795 no 2009 0.411339317151811 2795 1380876 SGTC_175 3793-3120 23.7 µM -0.224765534562484 0.406559427077397 no 2010 0.411080839742096 2821 5322297 SGTC_2054 5233173 129 µM -0.225676260351775 0.406184848411307 no 2011 0.410726611640671 2969 6889 SGTC_12 0849-0099 9.267 µM -0.225920367359031 0.406084462538946 no 2012 0.410631678229703 2820 6071388 SGTC_3126 9127922 49.47 µM -0.226130751226231 0.405997949828238 no 2013 0.410549863975152 3064 45595682 SGTC_1379 2144-0755 36.5 µM -0.226703440987775 0.405762475265896 no 2014 0.410327175628609 2949 5392327 SGTC_2646 retinol 96.75 µM -0.228273864193768 0.405116934834757 no 2015 0.409716670773741 2883 445354 A vitamin A analog and teratogen. SGTC_3268 9137683 49.47 µM -0.228482861393391 0.405031043564289 no 2016 0.409635439202522 2789 1953228 SGTC_2426 5582046 32.21 µM -0.229037016009388 0.404803325615792 no 2017 0.409420073044971 2970 2251934 SGTC_808 0711-0032 135 µM -0.229063170292401 0.404792578870412 no 2018 0.409409909142624 2780 4252555 SGTC_1040 k898-0338 155 µM -0.231399847903521 0.403832733197222 no 2019 0.408502091655888 3042 20969351 SGTC_1034 k072-0165 12.7 µM -0.231829520287661 0.403656297919613 no 2020 0.40833521385731 2990 5835461 SGTC_3048 9093155 49.47 µM -0.233660462579508 0.402904682914827 no 2021 0.407624292193641 2868 25236002 SGTC_3206 9114350 49.47 µM -0.233759766878214 0.402863928013455 no 2022 0.407585742809752 2935 17087243 SGTC_1094 duloxetine 25.4 µM -0.23404309412838 0.40274765512221 no 2023 0.407475761645768 2801 60834 A selective serotonin reuptake inhibitor. SGTC_1854 st056233 32.9 µM -0.234181657215966 0.402690794217814 no 2024 0.407421977276454 2814 5393174 SGTC_2501 sodium tetradecyl sulfate 13.37 µM -0.235185321468767 0.402278990948088 no 2025 0.407032449143215 2805 23665772 A membrane-active detergent. SGTC_330 1488-0319 80.1 µM -0.235224702793813 0.402262835005063 no 2026 0.407017166886124 2880 6846614 SGTC_2870 9038528 12.99 µM -0.236195760907455 0.401864517350707 no 2027 0.406640384389563 2951 6463316 SGTC_1138 3761-0006 1.03 µM -0.236410988593522 0.401776247038489 no 2028 0.406556885085666 2797 12061087 SGTC_2643 anethole 100 µM -0.236707795856729 0.401654527100816 no 2029 0.4064417433017 2874 637563 An anti-fungal, anti-helmenthic and channel blocker. SGTC_1692 fluoroquinolonic acid 71 µM -0.23730480265003 0.401409724970977 no 2030 0.406210168265322 2944 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2 SGTC_24 0417-1663 219 µM -0.23732975453552 0.401399494313167 no 2031 0.406200490305552 2909 4329390 SGTC_2634 4'-methoxyflavone 100 µM -0.23738884443901 0.401375266811149 no 2032 0.406177571636515 2893 77793 From seeds of Psoralea corylifolia (Fabaceae) SGTC_1864 st057645 30.4 µM -0.238136474678959 0.401068763072367 no 2033 0.405887622815597 2847 688666 SGTC_2012 4023501 200 µM -0.238975771699919 0.400724751517479 no 2034 0.405562184938777 2919 3477460 SGTC_1825 st052143 62.6 µM -0.241684232015548 0.399615132525809 no 2035 0.404512424223364 3008 674173 SGTC_1450 4112-4260 37.6 µM -0.24173552914452 0.399594124587293 no 2036 0.404492548790917 2979 1633175 SGTC_2151 5563267 85.4165 µM -0.242550332332841 0.399260473676019 no 2037 0.404176880661404 2858 5310824 SGTC_3348 9149464 3.537 µM -0.24255960300127 0.399256677885255 no 2038 0.404173289410818 2791 1951442 SGTC_845 0330-0138 4.51 µM -0.24350422260049 0.398869961981561 no 2039 0.403807407189317 2923 9039800 SGTC_2432 5630864 12.22 µM -0.244579455684431 0.398429895291232 no 2040 0.403391036496826 2983 5714970 SGTC_916 4466-0038 42 nM -0.24463397927592 0.398407583549812 no 2041 0.403369925824228 3014 5722064 YGL116W CDC20 SGTC_779 1360-0071 233 µM -0.245075543222131 0.398226902254663 no 2042 0.403198969624767 3033 7566 SGTC_922 1866-0035 480 µM -0.24611521428011 0.39780157079725 no 2043 0.402796522978932 2838 3156169 SGTC_1963 st076565 50.3 µM -0.246638786651653 0.397587422266024 no 2044 0.402593892117081 2865 4914280 SGTC_1840 st055363 71 µM -0.248534832636206 0.396812171224507 no 2045 0.401860311390652 2862 676033 SGTC_3168 9103419 49.47 µM -0.250807156058676 0.3958836059494 no 2046 0.400981604324996 2882 16649256 SGTC_2171 5739187 198.077 µM -0.251743351215328 0.395501209379695 no 2047 0.400619723204498 2792 2262761 SGTC_2696 st077691 74.316 µM -0.252145030928353 0.395337170830023 no 2048 0.40046448223369 2987 757133 SGTC_2962 9082311 13.18 µM -0.252450526889965 0.3952124243548 no 2049 0.400346424834723 2829 16459453 SGTC_1992 st073643 23.3 µM -0.254193644696994 0.394500843981035 no 2050 0.399672980096644 2825 3161292 SGTC_548 1436-0017 110 µM -0.2552926417958 0.394052389055304 no 2051 0.399248541350113 2994 9677137 SGTC_1265 0819-1001 68.8 µM -0.255482881005151 0.393974774603025 no 2052 0.399175081993066 2824 3106768 SGTC_3158 9100007 49.47 µM -0.256213801680323 0.393676610246774 no 2053 0.3988928760222 2882 19297233 SGTC_858 0438-0351 2.77 µM -0.259319292086129 0.392410484990873 no 2054 0.397694447733485 2895 2799119 SGTC_3054 9094397 49.47 µM -0.260412049173098 0.391965231984383 no 2055 0.397272974801877 2904 2598354 SGTC_1997 st073024 93.8 µM -0.261807773585269 0.391396738175813 no 2056 0.396734822801092 2993 686268 SGTC_3154 9100113 49.47 µM -0.262123760525621 0.391268065391739 no 2057 0.396613014401374 2891 25237525 SGTC_1558 st069300 45.6 µM -0.262541210777178 0.391098094060843 no 2058 0.396452108831118 2957 24208000 SGTC_2222 6885208 172.143 µM -0.263304842122735 0.390787223580907 no 2059 0.396157813931076 2910 609514 SGTC_1284 0929-0043 16 µM -0.263362692105179 0.390763675985127 no 2060 0.396135521609831 2932 1239883 SGTC_2240 6690706 185.951 µM -0.264235154344926 0.390408592464936 no 2061 0.395799362067293 2794 805876 SGTC_832 4083-0019 164 µM -0.264246680847989 0.390403901903008 no 2062 0.395794921425857 3001 1990758 SGTC_3065 9113888 49.47 µM -0.268127806494939 0.38882543889636 no 2063 0.39430047136628 3080 16648368 SGTC_1115 galangin 695.678 nM -0.269962653931944 0.388079838779568 no 2064 0.393594492512312 3006 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_2534 helenine 20.12 µM -0.27103903309456 0.387642638043197 no 2065 0.3931805056958 2833 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58 SGTC_2492 derrusnin 100 µM -0.272221822990854 0.387162379939536 no 2066 0.3927257314586 2819 1715307 Part of coumarin class of compounds. SGTC_905 2-aminofluorene 215 µM -0.272269983512389 0.387142828572611 no 2067 0.392707217181289 2894 1539 An established DNA mutagen. YPR165W RHO1 SGTC_1761 st044296 37 µM -0.273430664265102 0.386671722389887 no 2068 0.392261091935401 2879 1826700 SGTC_1477 0139-0234 16 µM -0.273568551139173 0.386615766868838 no 2069 0.392208102421439 2887 620880 SGTC_433 pimozide 108 µM -0.273675424820885 0.386572398353903 no 2070 0.392167032559657 2837 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic SGTC_1012 4112-3522 18 µM -0.275152725704668 0.385973066414862 no 2071 0.391599452499298 3055 3112398 SGTC_1512 0259-0544 12.2 µM -0.27534215544746 0.38589623557468 no 2072 0.391526690117073 2906 18476 SGTC_3351 9150312 21.596 µM -0.275509126735297 0.385828517373885 no 2073 0.391462557460805 2937 4904905 SGTC_3061 glucosamine 200 µM -0.275580154946018 0.38579971166366 no 2074 0.391435276851328 2977 91431 and experimental redox chemotherapeutic SGTC_3177 9107506 49.47 µM -0.278091723259687 0.384781543303188 no 2075 0.390470974566738 3004 8897194 SGTC_2316 5844804 197.44 µM -0.27822915632027 0.384725851965522 no 2076 0.390418227307292 3019 776813 SGTC_1948 st076329 66.6 µM -0.278372228587503 0.384667878006207 no 2077 0.39036331784459 2832 24208413 SGTC_2712 st079126 47.7 µM -0.28024616590567 0.383908783057717 no 2078 0.389644324909143 2881 3152970 SGTC_1154 4088-0362 150 µM -0.280756365295406 0.383702188358474 no 2079 0.389448636707153 2877 6618304 SGTC_1549 4'-methoxyflavonol 74.6 µM -0.281018754941965 0.38359595196064 no 2080 0.389348007438824 2910 97141 SGTC_2920 7982904 15.77 µM -0.281201322608665 0.383522039071196 no 2081 0.389277995140335 3010 6456808 SGTC_1794 st048918 76.9 µM -0.281709137782038 0.38331647136913 no 2082 0.389083273611039 2980 672303 SGTC_738 1315-0003 72.4 µM -0.281764691025395 0.383293984957756 no 2083 0.38906197343105 3061 6251474 SGTC_2039 Aminomethylbenzodioxan 200 µM -0.284717060362715 0.382099515229903 no 2084 0.387930459555378 2890 15053 SGTC_2655 perillic acid 100 µM -0.28564300863756 0.381725125477025 no 2085 0.387575779552607 2923 5702197 An apoptosis inducer. SGTC_1475 4092-1048 11.7 µM -0.286375317546569 0.381429108468353 no 2086 0.387295338582552 2983 2881759 SGTC_2941 9056145 11.23 µM -0.286798016459917 0.381258274878004 no 2087 0.387133490903859 2899 2119517 SGTC_730 1436-0052 41.2 µM -0.286948342991914 0.381197526047695 no 2088 0.387075936931146 2911 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2 SGTC_1787 fluconazole 80 µM -0.287275638751233 0.381065271868155 no 2089 0.386950637159441 2983 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C SGTC_692 k241-0027 77.8 µM -0.287366402106076 0.381028598530211 no 2090 0.38691589199515 3082 3600480 SGTC_838 0109-0203 71.4 µM -0.288044954877082 0.380754460137875 no 2091 0.386656163607338 2895 759422 SGTC_229 benomyl 22.8748 µM -0.288086312111161 0.380737753561924 no 2092 0.386640335015482 2991 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C SGTC_612 0302-0167 22.4 µM -0.289043726680926 0.380351060731361 no 2093 0.386273957948228 2988 235821 SGTC_2473 5854593 8.94 µM -0.289155164181103 0.380306059689293 no 2094 0.386231320364184 2882 2872951 SGTC_2888 9058547 12.99 µM -0.289771518194122 0.380057190946451 no 2095 0.385995519315777 2918 16476514 SGTC_2435 5706476 10.6 µM -0.291083532772329 0.379527596873803 no 2096 0.385493716920032 3070 5725375 SGTC_2436 5633522 8.09 µM -0.293647557272552 0.378493282611514 no 2097 0.384513615766929 3099 5724242 SGTC_1022 4477-0945 21.3 µM -0.293947528384061 0.378372332508919 no 2098 0.384398999568674 2924 4648966 SGTC_197 4544-0043 41.561 µM -0.294484002852717 0.378156052590802 no 2099 0.384194042821045 2914 896523 SGTC_416 estradiol valerate 100 µM -0.294594291111291 0.378111594559431 no 2100 0.384151911885476 2985 13791 A steroid. SGTC_2650 prasterone 100 µM -0.295560962609656 0.377721991094138 no 2101 0.383782694809106 2936 16759247 A steroid and weak partial agonist of the androgen receptor. SGTC_75 0159-0059 199.013 µM -0.296104691387351 0.377502903416761 no 2102 0.383575065675465 3230 5377270 SGTC_2365 9042475 200 µM -0.296352098917581 0.377403227159015 no 2103 0.383480601305085 3053 6464479 SGTC_475 α-linolenic acid 10 µM -0.297284330861459 0.377027720275105 no 2104 0.383124721674275 3153 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_1025 k007-0731 70 µM -0.297681106436563 0.376867932686702 no 2105 0.382973282463457 2931 6256118 SGTC_2744 captopril 92.04 µM -0.298398765052382 0.376578974175845 no 2106 0.382699415751275 3025 44093 angiotensin-converting enzyme (ACE) inhibitor  SGTC_892 0929-0076 29 µM -0.300053270699401 0.375913066676962 no 2107 0.382068261177727 2953 5751038 SGTC_2566 crystal violet carbinol 226 nM -0.300690046938708 0.37565687450345 no 2108 0.381825429576048 3091 68050 Cationic dye that binds acidic phospholipids including cardiolipin. SGTC_2341 7987486 176.74 µM -0.301219556338401 0.375443880393525 no 2109 0.381623539074929 3097 1258686 SGTC_1737 st035557 69.7 µM -0.301895982635879 0.37517184448053 no 2110 0.381365679178545 2875 5716916 SGTC_1342 1486-1464 234 µM -0.302002458246678 0.375129029221257 no 2111 0.381325094494594 2935 3253938 SGTC_1064 honokiol 6.76 µM -0.302952162243315 0.3747472087317 no 2112 0.38096315917359 3015 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis. SGTC_2894 9048625 32.47 µM -0.303979111842458 0.374334470439357 no 2113 0.380571902474736 3117 4092861 SGTC_1339 1486-1321 22.7 µM -0.304061948472792 0.374301184081854 no 2114 0.380540347931364 2964 3469382 SGTC_1798 st045719 60.953 µM -0.304407139825522 0.374162485454059 no 2115 0.380408864474258 2953 3980186 SGTC_2182 6325192 200 µM -0.304795858385958 0.374006316998365 no 2116 0.380260818033833 2951 736248 SGTC_1789 tunicamycin 25 nM -0.305359577737297 0.373779878368432 no 2117 0.380046152368805 3061 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_2584 androsterone 48.74 µM -0.305994818484182 0.373524762738812 no 2118 0.379804295467867 3077 2754130 A steroid. SGTC_2775 cyproheptadine 69.59 µM -0.306255507303569 0.373420084931155 no 2119 0.379705056318265 3040 2913 A selective serotonin reuptake inhibitor. SGTC_1 0258-0098 57.368 µM -0.306942648615531 0.373144212822723 no 2120 0.379443513001518 2999 6790032 YDR047W HEM12 SGTC_2183 6420625 130.508 µM -0.308234371857116 0.372625790487635 no 2121 0.378951999941921 2941 2897619 SGTC_3130 9127414 49.47 µM -0.308293620342454 0.372602017128463 no 2122 0.378929460013414 2974 1494646 SGTC_66 0109-0187 42.4 µM -0.308701827249978 0.372438237960606 no 2123 0.378774176865701 2861 759417 SGTC_2009 4012297 12.05 µM -0.308930886159128 0.372346345948078 no 2124 0.378687050729555 3054 45595307 SGTC_2154 5570129 200 µM -0.309915718905701 0.371951341515793 no 2125 0.37831252448984 2959 673366 SGTC_1700 st030840 7.9285 µM -0.309995477462078 0.3719193572215 no 2126 0.378282197767295 3056 5499307 SGTC_2976 9009005 19.48 µM -0.310583428169292 0.371683608068127 no 2127 0.378058663484107 3156 2993148 SGTC_1364 1653-0028 37.6 µM -0.311422099744148 0.371347411264419 no 2128 0.377739877729264 3007 5718652 SGTC_1622 st003707 19.4 µM -0.311546716708096 0.371297464648703 no 2129 0.377692516926425 3085 10140899 SGTC_1951 sophoraflavanone G 9.2 µM -0.311683331423464 0.371242711811512 no 2130 0.377640598478842 2964 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity. SGTC_1203 3992-3522 103 µM -0.312061791627662 0.371091045057774 no 2131 0.377496781697074 3290 5322312 SGTC_2442 5158906 48.48 µM -0.312258087146441 0.371012388120404 no 2132 0.377422195100233 3082 1893835 SGTC_1590 st077108 57.8 µM -0.313798913259502 0.370395156116178 no 2133 0.376836884910699 3062 5489485 SGTC_2598 perillyl alcohol 100 µM -0.317148193483393 0.369054636623276 no 2134 0.375565578897805 3125 10819 An apoptosis inducer. SGTC_3321 9137793 26.8275 µM -0.31788444912186 0.368760169639048 no 2135 0.375286294521498 3005 4904192 SGTC_303 1348-1668 34.2 µM -0.317951283999051 0.368733442701263 no 2136 0.375260945233581 2996 5380509 SGTC_2707 st078556 66.6 µM -0.3184013907868 0.368553463757944 no 2137 0.375090241717246 3037 17250899 SGTC_2825 7998094 58.44 µM -0.318586770353024 0.368479346576746 no 2138 0.3750199434143 3025 2987815 SGTC_1470 k295-0292 231 µM -0.319006967035187 0.368311364553377 no 2139 0.374860614831078 3067 5045612 SGTC_3184 9108758 49.47 µM -0.322629762173841 0.366864126863574 no 2140 0.373487825565539 2921 902885 SGTC_1658 st012944 20 µM -0.323951763971035 0.3663364819591 no 2141 0.372987276652312 3050 24207260 SGTC_1171 0368-0077 21.4 µM -0.324769240503569 0.366010332378401 no 2142 0.37267786309039 2958 3239779 SGTC_1653 st012112 65 µM -0.325041697400451 0.365901651422723 no 2143 0.372574756830366 3146 720429 SGTC_227 fluconazole 33.516 µM -0.325073360389839 0.365889021998087 no 2144 0.372562775151286 3015 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C SGTC_1979 st071809 45.3 µM -0.325184440955272 0.365844716414018 no 2145 0.372520741823679 3103 4976333 SGTC_1851 st056236 18.9 µM -0.325827757469641 0.365588158452205 no 2146 0.372277338170234 3152 5393171 SGTC_205 1486-1330 71.903 µM -0.326199246251928 0.365440034173351 no 2147 0.372136805817908 2997 4118834 SGTC_2910 7948405 25.97 µM -0.327030755360041 0.365108558056208 no 2148 0.371822311812865 3150 2971328 SGTC_362 0310-0100 9.03 µM -0.328084115116449 0.364688787212395 no 2149 0.371424032085245 3105 790235 SGTC_2769 toremifene 3.73 µM -0.328341828116809 0.364586111546849 no 2150 0.371326610660699 3191 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_1655 st012546 55.1 µM -0.328790814078679 0.364407253857422 no 2151 0.371156903364238 3090 720985 YLR208W SEC13 SGTC_2794 7785382 27.27 µM -0.328932815907301 0.364350692264876 no 2152 0.371103234857944 3061 2205081 SGTC_1827 berberine 7.24 µM -0.330902441739541 0.363566464013208 no 2153 0.370359088768258 2982 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_2821 7996764 71.43 µM -0.332609630425064 0.362887190074602 no 2154 0.369714486442135 3220 2987135 SGTC_1661 st013063 9.66 µM -0.333664751314545 0.362467583085034 no 2155 0.369316275504829 2998 721395 SGTC_609 0986-0026 86.3 µM -0.334019010045064 0.36232673629595 no 2156 0.369182606880438 2995 2848610 SGTC_1250 0485-0349 40.2 µM -0.337345529824568 0.361005084294616 no 2157 0.367928220628446 3016 6842794 YDL195W SEC31 SGTC_161 4065-0411 162.148 µM -0.337453157532522 0.360962350578001 no 2158 0.367887659084217 3113 1906281 YLR208W SEC13 SGTC_100 0086-0128 49.5915 µM -0.338519161142334 0.360539186305823 no 2159 0.367485995013642 3045 93297 SGTC_1208 2323-2347 50.3 µM -0.339337150228565 0.36021459042936 no 2160 0.367177879644104 3155 5412760 SGTC_653 0203-0016 55.2 µM -0.339454263911616 0.360168125409498 no 2161 0.367133772937135 3051 295302 SGTC_387 norethindrone acetate 66.7 µM -0.339996190947906 0.359953141993126 no 2162 0.366929698214566 3033 541197 SGTC_316 k060-0003 58.6 µM -0.341162056525606 0.359490791270685 no 2163 0.366490793024303 3127 6152314 SGTC_2841 9004761 38.96 µM -0.341299847935303 0.359436160502547 no 2164 0.366438931187268 3025 2991039 SGTC_775 4577-0580 57.3 µM -0.341460565942844 0.359372443554934 no 2165 0.36637844333437 3205 2006902 SGTC_148 3253-0744 288.01 µM -0.34173761061165 0.359262617870734 no 2166 0.366274182555702 2999 6893655 SGTC_358 0075-0058 9.45 µM -0.342839174980192 0.358826052277808 no 2167 0.365859726333972 3163 1069125 SGTC_140 0062-0056 502.533 µM -0.343251281069195 0.358662776140507 no 2168 0.365704714376318 2959 3758964 SGTC_3070 9117005 49.47 µM -0.343783352172172 0.358452008153679 no 2169 0.36550461051955 3077 8779016 SGTC_2733 amorolfine 100 µM -0.344651750669704 0.35810810426899 no 2170 0.365178097675808 3061 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_3249 9135183 49.47 µM -0.345163369358055 0.357905546477792 no 2171 0.364985777715883 3170 4902779 SGTC_1017 4239-0030 168 µM -0.345452185799368 0.357791217219892 no 2172 0.36487722520054 3028 1149593 SGTC_811 0416-0114 265 µM -0.345587182497747 0.35773778255757 no 2173 0.364826490005006 3108 6612453 SGTC_1680 diphenhydramine 100 µM -0.345607947026977 0.357729563747574 no 2174 0.364818686376381 3048 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1 SGTC_2267 7931562 200 µM -0.346277551563939 0.357464562901814 no 2175 0.364567068756868 2963 934880 SGTC_2253 7938677 135.83 µM -0.34663029638356 0.357324989209281 no 2176 0.364434541119651 3194 2301972 SGTC_1427 4048-4900 550 nM -0.34702140889143 0.357170256543383 no 2177 0.364287617532303 3134 24132586 SGTC_3020 9089140 49.47 µM -0.347039231340438 0.357163206151901 no 2178 0.364280922905144 3102 17217859 SGTC_615 k087-0205 167 µM -0.347395068678477 0.357022450492371 no 2179 0.364147268781209 3027 9642773 SGTC_280 3448-3607 3.04 µM -0.349039560253661 0.356372205469141 no 2180 0.363529805093576 3118 626179 SGTC_581 0958-0271 211 µM -0.349627481888258 0.356139837762322 no 2181 0.363309141759628 3023 4591145 SGTC_1919 st067113 52.3 µM -0.350759519840869 0.35569256629121 no 2182 0.362884384241225 3152 1268243 SGTC_1495 4469-0029 237 µM -0.356139011933409 0.353569837051033 no 2183 0.360868231356543 3035 793680 SGTC_622 1348-1566 26.3 µM -0.356543556862576 0.353410387970384 no 2184 0.360716769365536 3100 7340407 SGTC_2813 7971799 71.43 µM -0.357599567753795 0.352994288565167 no 2185 0.360321500915733 3128 2234054 SGTC_1412 3909-8563 178 µM -0.357759355795193 0.352931342664228 no 2186 0.360261704700837 3147 23767530 SGTC_647 0140-0236 81 µM -0.358054338744888 0.352815149502023 no 2187 0.360151324545534 3074 990837 SGTC_1143 3454-2408 5.08 µM -0.359513680753485 0.352240519882569 no 2188 0.359605422617444 3060 X1143 SGTC_2489 cantharidin 73.42 µM -0.359642564121981 0.352189787030884 no 2189 0.359557224443838 3010 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_211 3455-0679 143.504 µM -0.360000574390268 0.352048875888147 no 2190 0.359423352011418 3122 748649 SGTC_1400 3771-8998 51.5 µM -0.360316603837333 0.35192450507721 no 2191 0.359305191997658 3027 670767 SGTC_2621 lithochol-11-enic acid 100 µM -0.360874171233943 0.351705117612147 no 2192 0.359096756354939 3160 6708711 SGTC_698 k064-0052 127 µM -0.36190944301765 0.3512978975818 no 2193 0.358709851552971 3124 5088751 SGTC_3002 9075603 71.4286 µM -0.363320736465964 0.350743045872588 no 2194 0.358182652363815 3079 20105405 SGTC_1553 gossypol 38.6 µM -0.365196744389666 0.350005983858454 no 2195 0.357482274161682 3027 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_365 0121-0052 13.6 µM -0.36522957655316 0.349993089498217 no 2196 0.357470021051837 3166 3101739 SGTC_3273 9137859 49.47 µM -0.365535160569703 0.34987308406742 no 2197 0.357355982783431 3122 2377234 SGTC_2749 bexarotene 57.39 µM -0.36720028857637 0.349219437944069 no 2198 0.356734812040618 3122 82146 An retinoic acid receptor inhibitor. SGTC_2146 5545642 200 µM -0.367209088857017 0.349215984579052 no 2199 0.356731530131052 3122 825326 SGTC_1376 2910-0861 41.3 µM -0.367846303788886 0.348965964868675 no 2200 0.356493920253288 3052 1112859 SGTC_1399 3562-5772 25 µM -0.367957534346394 0.348922328804953 no 2201 0.356452449406343 2993 23847490 SGTC_3038 9091290 49.47 µM -0.368559993145388 0.34868601723647 no 2202 0.35622786008975 3216 25236843 SGTC_389 tpck 16.7 µM -0.368584260060132 0.348676499884946 no 2203 0.356218814723139 3121 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.  SGTC_2153 5569715 200 µM -0.369014434762448 0.348507803526624 no 2204 0.356058482767062 3102 2054701 SGTC_2638 epoxomicin 18 µM -0.36913915822914 0.348458897848694 no 2205 0.356012001394348 3171 9915668 A protesome inhibitor. SGTC_1166 k206-0078 225 µM -0.369773387347047 0.348210247428847 no 2206 0.355775672901173 3041 5404595 SGTC_369 0957-0393 4.5 µM -0.369782561764481 0.348206651063945 no 2207 0.35577225470667 3092 6997992 SGTC_1631 benzylvanillin 81.9 µM -0.37024163350827 0.348026712712949 no 2208 0.355601229066904 3178 75506 SGTC_2602 kawain 100 µM -0.372145612403523 0.34728079230003 no 2209 0.354892218723915 3126 5369129 SGTC_2152 5568786 200 µM -0.372710798726007 0.347059483324574 no 2210 0.354681849220992 3103 5399883 SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM -0.372766556496355 0.347037653181467 no 2211 0.354661097873481 3177 6708760 SGTC_602 3130-1533 38.1 µM -0.374091381935124 0.346519110298261 no 2212 0.354168165105366 3168 720941 SGTC_1507 4075-3230 155 µM -0.374468356452741 0.346371613201471 no 2213 0.354027947387243 3124 659771 SGTC_1053 3366-3204 134 µM -0.375250987454502 0.346065471147758 no 2214 0.353736906756833 3097 3632071 YPR165W RHO1 SGTC_2403 6032726 181.2 µM -0.375995973230592 0.345774148224042 no 2215 0.353459944823171 3131 2881040 SGTC_558 k064-0027 21.3 µM -0.376087601173247 0.345738323881187 no 2216 0.353425885832886 3149 5088526 SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM -0.376347212770828 0.345636829432485 no 2217 0.353329392071792 3136 1241132 A phosphatase inhibitor. SGTC_2618 avocadyne 43.43 µM -0.378491157084817 0.344799084950409 no 2218 0.352532880839844 3027 3015189 SGTC_368 fentichlor 4.58 µM -0.37871114452151 0.344713167985796 no 2219 0.352451188316173 3117 7329 A pesticide. SGTC_3139 9095020 49.47 µM -0.379166567262634 0.344535326286162 no 2220 0.352282088322224 2975 25236292 SGTC_208 k072-0098 12.366 µM -0.382291694944339 0.343315898594829 no 2221 0.351122507101044 3089 5948901 SGTC_2104 5389443 200 µM -0.383059909125747 0.343016389727796 no 2222 0.350837672222914 3253 2244536 SGTC_2781 5567276 71.43 µM -0.38528385424416 0.342149881686838 no 2223 0.350013561204529 3240 2853274 SGTC_2512 diallyl trisulfide 49.23 µM -0.385296854093934 0.342144819037646 no 2224 0.350008746017248 3145 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent SGTC_195 4234-0266 16.654 µM -0.385829266713339 0.341937501158217 no 2225 0.349811559354044 3114 2303354 SGTC_1664 st014217 9.02 µM -0.386071572521079 0.341843164686654 no 2226 0.349721831324766 3179 3982782 SGTC_322 k048-0136 19.3 µM -0.389021252674903 0.340695564477703 no 2227 0.348630212461811 3184 6823282 SGTC_2999 9069765 71.4286 µM -0.389128820635943 0.340653741947222 no 2228 0.348590427276373 3138 2097066 SGTC_869 0564-0080 44.1 µM -0.391211657995642 0.339844319440704 no 2229 0.347820395898805 3121 6843321 SGTC_1081 sertraline 6 µM -0.391249925795151 0.339829454879153 no 2230 0.347806254034483 3196 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1 SGTC_1574 spiramycin 23.7 µM -0.392613260707376 0.339300050206879 no 2231 0.347302571925549 3045 6419898 An antibiotic and protein synthesis inhibitor. SGTC_2785 7756463 72.73 µM -0.393059972023962 0.339126653994183 no 2232 0.347137593663845 3067 2201551 SGTC_1035 k081-0041 55.2 µM -0.39321770856374 0.339065434851721 no 2233 0.347079345733367 3239 731709 SGTC_494 Boc-Gly-Val-Val-CHO 140 µM -0.393931514512036 0.338788452704395 no 2234 0.346815801267218 3095 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA. SGTC_2134 5324836 1.464 µM -0.393998663044185 0.338762401163347 no 2235 0.346791013152712 3077 699272 SGTC_170 4197-0004 226 µM -0.396489057655869 0.337796751241685 no 2236 0.345872139297658 3210 218692 SGTC_1944 st076371 56.9 µM -0.397867991111994 0.337262528508206 no 2237 0.345363747893563 3072 24208455 SGTC_3143 9086658 49.47 µM -0.398401444421253 0.33705594735922 no 2238 0.345167146680246 3143 25236626 SGTC_1269 0831-0796 3.05 µM -0.398413565635869 0.337051253958716 no 2239 0.345162679960114 3229 927758 SGTC_546 peri-Naphthalide 147 µM -0.39867053595689 0.336951759617053 no 2240 0.345067990359783 3129 223824 A penicillin ester. SGTC_1084 voriconazole 435 nM -0.399894575725741 0.336477989848745 no 2241 0.344617083820499 3215 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_2694 st077685 81.9 µM -0.400633547966034 0.336192093083679 no 2242 0.34434497116792 3048 2838096 SGTC_3322 9139058 2.11 µM -0.401233334569507 0.335960114685436 no 2243 0.344124170227592 3277 4908926 YPR165W RHO1 SGTC_928 2764-0428 58.7 µM -0.402344760070071 0.335530415815711 no 2244 0.343715158876276 3209 662578 SGTC_1886 st057356 49.9 µM -0.402753788073597 0.335372331673707 no 2245 0.343564680089304 3103 24207747 SGTC_256 clotrimazole 625 nM -0.405108226775677 0.334462938393311 no 2246 0.342698979785545 3179 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C SGTC_1915 st067105 30.6 µM -0.406833971068142 0.333796991992406 no 2247 0.342064967198974 3173 69751 YOR207C | YOR116C RET1 | RPO31 SGTC_1934 st074720 32.6 µM -0.408285607032719 0.333237226085039 no 2248 0.341532002413421 3074 17250992 SGTC_2459 5811157 9.22 µM -0.408747591505526 0.333059157889532 no 2249 0.341362452079958 3168 2870684 YBR192W RIM2 SGTC_1063 disulfiram 1.84 µM -0.408822880898788 0.333030141764349 no 2250 0.341334823574476 3139 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_2206 7254556 146.969 µM -0.410925322995353 0.332220276200318 no 2251 0.340563646685661 3172 4398905 SGTC_1419 3993-2473 62.6 µM -0.413198391585346 0.331345565660079 no 2252 0.339730633225809 3179 704026 SGTC_429 1112-0049 25.5 µM -0.41441718542208 0.330876933963124 no 2253 0.339284302612498 3073 2836170 SGTC_2279 7948423 32.93 µM -0.414486963460614 0.330850112004682 no 2254 0.339258756234847 3316 1247112 SGTC_2864 9034755 47.6 µM -0.415199812442238 0.330576149974598 no 2255 0.338997818054593 3235 4930451 SGTC_113 0099-0221 2.5 µM -0.415690472128781 0.330387632427029 no 2256 0.338818257067696 3301 89219 SGTC_636 0kpi-0074 126 µM -0.416466517190067 0.330089554149715 no 2257 0.338534331710639 3189 616434 SGTC_2225 6654152 15.4 µM -0.416827226896931 0.329951042538547 no 2258 0.338402392979994 3185 97582 YGR029W | YLR033W ERV1 | RSC58 SGTC_1308 1187-1617 41.4 µM -0.417409381189371 0.329727545943796 no 2259 0.33818949711802 3111 2882570 SGTC_151 3013-0144 2.285 µM -0.419032449228203 0.329104750232769 no 2260 0.337596208791505 3296 906558 YHR107C CDC12 SGTC_2000 st075254 36.4 µM -0.4207193166299 0.328457976044358 no 2261 0.336980027040716 3197 17234175 SGTC_1078 idebenone 36.1 µM -0.421187153097698 0.328278690343929 no 2262 0.336809212321898 3206 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen. SGTC_630 4356-0227 183 µM -0.421846225916633 0.328026185572373 no 2263 0.336568631204372 3207 779312 SGTC_669 0108-0021 26.2 µM -0.424623021590533 0.326963200353639 no 2264 0.335555753940069 3452 17201 SGTC_896 0964-0007 44.5 µM -0.425817707990802 0.326506293400294 no 2265 0.335120341272646 3254 6756758 SGTC_2956 9076196 2.52 µM -0.42590383964083 0.326473362459093 no 2266 0.33508895848096 3287 16423868 SGTC_1523 st012844 44.7 µM -0.42620577667745 0.326357932755591 no 2267 0.334978954272748 3293 4274103 SGTC_2165 5727197 32.143 µM -0.426221959787093 0.326351746466434 no 2268 0.334973058707474 3458 1361712 SGTC_48 0382-0018 55 µM -0.426274336109194 0.326331724988433 no 2269 0.334953978103014 3392 762596 SGTC_2185 6113692 200 µM -0.426963567092297 0.326068304808033 no 2270 0.334702932139363 3264 874150 SGTC_1964 st076914 61 µM -0.427072199214764 0.32602679413839 no 2271 0.334663370637078 3198 24208661 SGTC_2272 7805186 180 µM -0.42954513741292 0.325082415291877 no 2272 0.333763276479281 3281 2956062 YPR165W RHO1 SGTC_2103 5378138 10 µM -0.429636115795277 0.32504769335532 no 2273 0.333730180581683 3260 244142 SGTC_2398 5228213 48.84 µM -0.431225601759725 0.324441310776002 no 2274 0.333152170119553 3348 80771 YMR134W ERG29 SGTC_2343 7990716 14.84 µM -0.431864069711936 0.324197868655398 no 2275 0.332920105129436 3115 6456862 SGTC_247 mechlorethamine 29.705 µM -0.432067249881135 0.324120413629748 no 2276 0.332846268317188 3150 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links. SGTC_500 h-89 112 µM -0.432200284433185 0.324069703184649 no 2277 0.332797926326559 3301 449241 Protein kinase A inhibitor; also known to inhibit several other kinases. SGTC_1796 st049173 110.4 µM -0.432493248748042 0.323958041820557 no 2278 0.3326914789858 3261 94134 SGTC_2895 9054447 58.44 µM -0.433970139558512 0.323395376244527 no 2279 0.332155062494256 3177 2697450 SGTC_2336 9001819 198.65 µM -0.434273623326277 0.323279805010268 no 2280 0.332044877724101 3373 2989602 SGTC_1506 4226-2149 212 µM -0.435931650884389 0.322648704205633 no 2281 0.331443160156517 3245 991114 SGTC_2192 5915882 198.485 µM -0.436352969196285 0.322488417630125 no 2282 0.331290328040691 3200 2876149 SGTC_979 1426-2828 121 µM -0.437304533811795 0.322126525281151 no 2283 0.330945253880596 3302 747872 SGTC_1703 st026983 48.3 µM -0.441263219167067 0.320622798540205 no 2284 0.329511225164832 3314 1104023 SGTC_1543 azetidyl-2-carboxylic acid 198 µM -0.44185371826261 0.320398745777234 no 2285 0.329297531691967 3180 16486 A toxic proline analog. SGTC_2100 5377183 190 µM -0.44293134238783 0.319990032159383 no 2286 0.32890769813727 3238 2844202 SGTC_2261 9010538 184.68 µM -0.443149042543535 0.319907490891827 no 2287 0.328828967069258 3272 6457250 SGTC_3101 9120531 49.47 µM -0.443337891667365 0.319835895747929 no 2288 0.328760676103172 3371 24824904 SGTC_1107 amlodipine 47 µM -0.44353802299495 0.319760030699405 no 2289 0.328688311545585 3239 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.  SGTC_2783 7738165 71.43 µM -0.443689823561784 0.319702491726356 no 2290 0.32863342696702 3221 17201110 SGTC_1780 st038448 24.544 µM -0.444364009626718 0.319446998525192 no 2291 0.328389714861366 3338 728868 YDL195W SEC31 SGTC_664 1222-0054 14.9 µM -0.444939190142347 0.319229092735417 no 2292 0.328181850062096 3205 6813991 SGTC_2703 st077852 53.4 µM -0.447484952132167 0.318265387310896 no 2293 0.327262475205763 3294 6281836 SGTC_3025 9087895 49.47 µM -0.448176907813 0.318003657629973 no 2294 0.327012763496764 3311 17173641 SGTC_2116 5511452 16.8835 µM -0.44844365494453 0.31790278577322 no 2295 0.326916520948749 3303 870744 SGTC_496 calpeptin 138 µM -0.451182455720148 0.316867876173631 no 2296 0.325929026618183 3242 73364 A calpain inhibitor. SGTC_3081 9117243 49.47 µM -0.451394753282691 0.316787715048532 no 2297 0.325852532056402 3338 45595589 SGTC_1584 6-fluoro-dl-tryptophan 90 µM -0.452320127572832 0.316438404825381 no 2298 0.32551918900009 3372 94937 An inhibitor of serotonin biosynthesis. SGTC_802 4112-3352 742 µM -0.452719829619316 0.3162875759277 no 2299 0.325375249412383 3326 704594 SGTC_1170 0310-0127 64.8 µM -0.453529047594603 0.315982308413331 no 2300 0.325083915846451 3240 774975 SGTC_697 0508-1955 564 µM -0.454805270810137 0.315501123882046 no 2301 0.324624668984498 3345 6243113 SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM -0.455596159916222 0.315203085575399 no 2302 0.324340202522144 3285 616764 SGTC_2934 9036370 36.88 µM -0.455839944600243 0.315111242095436 no 2303 0.324252538867396 3268 6462800 SGTC_1231 0242-0792 125 µM -0.456153576384498 0.314993101217368 no 2304 0.324139772901026 3176 3707635 SGTC_484 loperamide 105 µM -0.456885878327099 0.314717326616302 no 2305 0.323876537356697 3212 3955 An opioid-receptor agonist. SGTC_2961 9083290 32.55 µM -0.457441667571021 0.314508093159248 no 2306 0.323676810390736 3287 17741490 SGTC_2876 9059903 25.97 µM -0.458553688177066 0.31408963866007 no 2307 0.323277350047269 3295 6916095 SGTC_2197 6588183 93.1375 µM -0.458682352384321 0.314041237596262 no 2308 0.323231144392509 3205 884136 SGTC_1753 st043925 64 µM -0.458941897666167 0.313943611259413 no 2309 0.323137945264507 3296 670181 SGTC_2612 dictamnine 15.46 µM -0.459699799964968 0.313658605592877 no 2310 0.322865856565952 3252 68085 A quinoline derivative and established mutagen. YOR116C RPO31 SGTC_918 glabranin 770.725 nM -0.459746486357914 0.313641053023626 no 2311 0.322849099139452 3249 124049 Also referred to as licorice root. SGTC_2288 7946289 167.31 µM -0.460596190495458 0.313321665579051 no 2312 0.322544172619881 3378 1246052 SGTC_2918 7977171 22.06 µM -0.461599637653707 0.312944669325946 no 2313 0.322184227239067 3244 2236483 SGTC_2635 hydroquinidine 100 µM -0.462913322915174 0.312451411816459 no 2314 0.321713248700745 3208 442912 An experimental heart treatment. SGTC_456 gingerol 170 µM -0.463470649841333 0.312242250245487 no 2315 0.321513523972985 3388 442793 A herb. SGTC_1105 epirubicin 18.1 µM -0.463679142248693 0.312164019796567 no 2316 0.32143882149618 3191 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_403 arphamenine a 50 µM -0.463753044463548 0.312136292265903 no 2317 0.321412344191007 3254 5487158 An arginine aminopeptidase inhibitor. SGTC_1149 3909-7961 23.3 µM -0.463793143797636 0.312121247756008 no 2318 0.321397977987733 3250 735261 SGTC_638 3970-0837 4.09 µM -0.464197729270638 0.311969472489796 no 2319 0.321253043968603 3229 4118451 YLR208W SEC13 SGTC_2028 5153890 36.43 µM -0.464458280240227 0.311871746891656 no 2320 0.321159721610182 3250 2830968 YPR165W RHO1 SGTC_2158 5657123 3.6195 µM -0.466286710571715 0.311186325161747 no 2321 0.320505144945427 3290 2858827 SGTC_426 0988-0037 14.6 µM -0.467727763179886 0.310646580133319 no 2322 0.319989642203234 3372 5383008 SGTC_527 4476-4215 268 µM -0.467752989398523 0.310637135298895 no 2323 0.319980621206662 3205 4418754 SGTC_1402 3909-7673 35.9 µM -0.468895733270302 0.310209416697646 no 2324 0.319572083128271 3262 5328014 SGTC_2080 5212524 12.4 µM -0.469815663043875 0.309865281778527 no 2325 0.319243361463929 3326 260183 SGTC_2258 7960471 200 µM -0.470157698682864 0.309737372720862 no 2326 0.319121176907155 3262 2974708 SGTC_3350 9150499 3.57 µM -0.471151525970937 0.30936584771392 no 2327 0.318766265929872 3214 4910996 YPR165W RHO1 SGTC_3087 9117406 49.47 µM -0.471230212586313 0.30933644041167 no 2328 0.318738172826392 3316 42546093 SGTC_1941 st076221 61.8 µM -0.473345370194574 0.308546407286918 no 2329 0.317983399064673 3314 2828568 SGTC_652 0437-0092 114 µM -0.473358841148792 0.308541378581089 no 2330 0.317978594501214 3279 3091274 SGTC_1113 artemisinin 1.17947 µM -0.474816678339022 0.307997380511208 no 2331 0.317458822094692 3321 2240 An anti-malaria and mitochondrial poison. SGTC_191 3914-0123 66.505 µM -0.475987909017823 0.307560636216404 no 2332 0.317041495928437 3201 3144412 SGTC_807 1315-0151 48 µM -0.476421785091204 0.307398915824779 no 2333 0.316886958722779 3411 4011080 SGTC_1991 st073000 8.92 µM -0.47684549805453 0.307241019700669 no 2334 0.316736072222625 3429 4301969 YIL048W NEO1 SGTC_1367 1812-0510 76.9 µM -0.477451884607376 0.307015112639787 no 2335 0.316520187693612 3282 1142582 YDR527W RBA50 SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM -0.478031513661996 0.306799242449084 no 2336 0.316313887733159 3243 6708784 An antioxidant flavonoid SGTC_2352 9027995 87.8 µM -0.478425287235076 0.306652628280693 no 2337 0.316173769538107 3280 2997347 SGTC_2440 5628896 157.78 µM -0.479026821075096 0.30642871821681 no 2338 0.315959774050056 3231 5522048 SGTC_3188 9110789 49.47 µM -0.479499477995639 0.306252830935652 no 2339 0.315791669740803 3389 849217 SGTC_2596 sinensetin 100 µM -0.479666395160588 0.306190727611988 no 2340 0.315732313382926 3243 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets. SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM -0.481152038249951 0.305638223671385 no 2341 0.315204222760367 3399 23847180 SGTC_363 0455-0021 3.06 µM -0.483358553490138 0.304818446989001 no 2342 0.314420585714424 3270 4597466 SGTC_3044 9093193 49.47 µM -0.485313224253926 0.304093054359336 no 2343 0.31372708812119 3319 25236277 SGTC_1572 epiandrosterone 68.9 µM -0.48787600605395 0.303143154731775 no 2344 0.31281883538261 3288 441302 A steroid. SGTC_1901 st060216 58.6 µM -0.488121765177774 0.303052133446864 no 2345 0.312731797636014 3236 688792 SGTC_355 1311-2252 105 µM -0.488219837430304 0.303015814048517 no 2346 0.312697067402911 3259 5338538 SGTC_2205 7238770 200 µM -0.488369208535455 0.302960500731179 no 2347 0.312644173951278 3366 279867 SGTC_3352 9151559 45.5865 µM -0.488806072727642 0.302798752361261 no 2348 0.312489499144343 3273 17159339 SGTC_2097 5376186 200 µM -0.489035063772357 0.302713984190932 no 2349 0.312408436462863 3333 742755 SGTC_2572 astragaloside iv 100 µM -0.489149755982439 0.302671531291615 no 2350 0.312367838906369 3366 45006101 An anti-inflammatory agent. SGTC_3213 9129884 49.47 µM -0.489254854263996 0.302632631891844 no 2351 0.312330639308696 3314 17190742 SGTC_3030 9087619 49.47 µM -0.48963551211617 0.302491760027223 no 2352 0.312195921253512 3285 25236973 SGTC_2326 6164455 177.58 µM -0.491467745826842 0.301814108287424 no 2353 0.311547829670186 3297 2888790 SGTC_3201 9113999 49.47 µM -0.491834167449787 0.301678669143255 no 2354 0.311418290180202 3376 16649224 SGTC_1916 st067606 49.2 µM -0.493196022956791 0.30117553098494 no 2355 0.310937043859149 3298 19590279 SGTC_2135 5326629 150.42 µM -0.493444330814015 0.30108383429366 no 2356 0.310849332764126 3259 5020077 SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM -0.494335233838524 0.300754939612346 no 2357 0.31053472286186 3313 676296 Flavone; oxidizing agent. SGTC_1459 k035-0031 35.7 µM -0.498000130887381 0.299403677961703 no 2358 0.309241974965536 3223 3877128 YMR208W ERG12 SGTC_1961 st076550 68.7 µM -0.498098576846874 0.299367418553143 no 2359 0.309207281802042 3360 1579337 SGTC_224 benfluorex 43.875 µM -0.500417760695173 0.29851379836973 no 2360 0.308390475034502 3380 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis. SGTC_2390 9097792 176.6 µM -0.500484159362121 0.298489375376951 no 2361 0.308367103638883 3301 4497149 SGTC_406 estrone 100 µM -0.50080019544016 0.298373142330898 no 2362 0.308255874037391 3403 5870 A steroid. SGTC_1532 4',5'-dihydroxyflavone 78.7 µM -0.500981388789548 0.298306511590004 no 2363 0.308192110573327 3368 165521 SGTC_1435 4092-0789 56.7 µM -0.501844331334549 0.297989272294945 no 2364 0.307888513280547 3370 2248285 SGTC_3196 9111891 49.47 µM -0.503501491900588 0.297380490161791 no 2365 0.307305865841514 3361 18891510 SGTC_1454 4239-0054 42.6 µM -0.504557679672273 0.29699278084018 no 2366 0.306934770214925 3453 1340767 SGTC_1005 4092-0690 4.4 µM -0.504631462558525 0.29696570498736 no 2367 0.306908853699229 3285 1529343 SGTC_2669 eugenol 100 µM -0.504853265981174 0.296884317346375 no 2368 0.30683095022549 3338 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism. SGTC_642 0335-0876 158 µM -0.504894999444621 0.296869004980955 no 2369 0.306816293258139 3320 6812350 SGTC_2077 5212015 200 µM -0.504943450485522 0.296851228332175 no 2370 0.306799277436822 3294 780900 SGTC_530 4358-1714 28 µM -0.508487795898076 0.29555213435256 no 2371 0.305555647827353 3363 1564641 SGTC_347 4534-1311 26.2 µM -0.509403301942661 0.295217003066269 no 2372 0.305234781175631 3351 2862016 SGTC_2684 capsaicin 100 µM -0.50993022532751 0.295024196185063 no 2373 0.305050172833486 3405 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_2991 9074669 71.4286 µM -0.510000220411632 0.294998588603107 no 2374 0.305025653689119 3430 17333109 SGTC_587 k089-0003 57 µM -0.51208450602035 0.294236525972019 no 2375 0.304295933888004 3375 9659696 SGTC_670 4204-0025 119 µM -0.512242050973384 0.294178960908757 no 2376 0.304240808151861 3370 719039 SGTC_1857 st056007 79.3 µM -0.513129070190143 0.293854951741333 no 2377 0.303930518926492 3397 619834 SGTC_203 k066-0004 30.888 µM -0.513291593070099 0.293795603504024 no 2378 0.30387368190869 3412 6795412 SGTC_3332 9141069 11.198 µM -0.514048444462084 0.293519298285077 no 2379 0.303609060561 3262 17332883 SGTC_713 1488-1073 324 µM -0.514832455008016 0.293233204984855 no 2380 0.303335051977784 3377 3312542 SGTC_1356 1502-0781 85.8 µM -0.517280069702694 0.292340878691545 no 2381 0.302480332357233 3289 567702 SGTC_2301 7769476 200 µM -0.517450783246141 0.292278688832671 no 2382 0.302420758613183 3336 977820 SGTC_3203 9113543 49.47 µM -0.517494609867266 0.292262724065878 no 2383 0.302405465327438 3393 17018012 SGTC_1304 1165-0502 251 µM -0.517730442514723 0.292176824038029 no 2384 0.302323177554143 3301 767425 SGTC_1352 1496-0991 99 µM -0.52049780777217 0.2911697137444 no 2385 0.301358327724614 3331 3000039 SGTC_458 nppb 133 µM -0.522036282855374 0.290610527882719 no 2386 0.300822534277025 3480 4549 A chloride channel blocker. SGTC_1333 1482-0047 286 µM -0.522412541200429 0.290473846662108 no 2387 0.300691562967282 3425 3811116 SGTC_1252 0493-0875 34.8 µM -0.522871934520949 0.290307006281291 no 2388 0.300531688207625 3314 3960963 SGTC_1068 loratadine 26.9 µM -0.52742713831542 0.28865510200404 no 2389 0.298948500907871 3354 3957 A H1 histamine antagonist. SGTC_555 4296-0685 37 µM -0.528503350879773 0.288265470573652 no 2390 0.298575010973788 3372 2908540 YHR072W ERG7 SGTC_99 0109-0120 622.8 µM -0.528589121347205 0.288234428953564 no 2391 0.298545254234128 3483 759414 SGTC_1747 st037496 66.6 µM -0.528848459760986 0.288140580079517 no 2392 0.298455288981779 3324 723305 SGTC_668 1682-0499 62.6 µM -0.528894129408777 0.288124054730537 no 2393 0.298439447325266 3371 682214 SGTC_129 0088-0017 176.636 µM -0.529240661420761 0.287998678311484 no 2394 0.298319256521694 3413 182446 SGTC_1819 st053448 58.6 µM -0.529360478203924 0.287955334198738 no 2395 0.298277704520286 3309 2857616 SGTC_1072 oxiconazole 14.9 nM -0.529435155007786 0.287928321179011 no 2396 0.298251808223882 3412 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_1640 st009078 66.4 µM -0.533237456524914 0.2865544895965 no 2397 0.296934607994915 3411 690618 SGTC_1392 3455-1037 33.9 µM -0.53334790208275 0.286514630389642 no 2398 0.296896387050983 3467 981132 SGTC_6 0844-0013 19.835 µM -0.53500014077369 0.285918660591325 no 2399 0.296324879970414 3480 1584900 SGTC_2338 7999974 200 µM -0.535262602626736 0.285824043711297 no 2400 0.296234141227357 3427 315925 SGTC_3236 9132701 49.47 µM -0.537081877531944 0.285168609038211 no 2401 0.295605529154594 3392 24282524 SGTC_2714 st079313 56.9 µM -0.538695921032539 0.284587713926105 no 2402 0.295048344357995 3389 2939799 SGTC_1290 0986-0249 10.2 µM -0.539979593035312 0.284126123463765 no 2403 0.294605552943248 3370 53329 SGTC_1958 st076513 41.9 µM -0.541315792880454 0.283646025395189 no 2404 0.294144968423566 3326 732122 YGL099W LSG1 SGTC_2909 7941780 10.49 µM -0.541351770349436 0.283633104025421 no 2405 0.294132571687517 3478 1243215 SGTC_235 0330-0087 5 mM -0.541768240922437 0.283483548432292 no 2406 0.293989086235859 3406 46494818 YHR062C RPP1 SGTC_667 1498-1044 59 µM -0.542316421974928 0.283286752920079 no 2407 0.29380027228683 3373 6739982 SGTC_541 4513-1321 94 µM -0.542598694641557 0.283185443359482 no 2408 0.293703068966574 3343 747515 SGTC_1757 st041620 31.8375 µM -0.54347918894031 0.282869539747748 no 2409 0.293399957913313 3404 5289815 SGTC_2264 7948757 110.76 µM -0.543863981446194 0.282731537113168 no 2410 0.293267538228482 3305 2971411 SGTC_963 1269-2853 151 µM -0.54413100791679 0.282635789305708 no 2411 0.29317566197306 3352 3668223 SGTC_690 glyoxal 20.3 µM -0.545097131613904 0.282289496133777 no 2412 0.29284335768688 3386 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins. SGTC_417 st075190 100 µM -0.545320407329959 0.282209495210656 no 2413 0.29276658548908 3477 222757 SGTC_975 1335-0046 28.5 µM -0.545356298129188 0.282196636357031 no 2414 0.292754245495712 3369 16486740 SGTC_454 lyso-paf C-16 6.67 µM -0.54547661237375 0.282153532568528 no 2415 0.292712880751201 3380 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_3112 9123419 49.47 µM -0.54572361273118 0.282065052139218 no 2416 0.292627969083951 3462 17015854 SGTC_2686 alizarin 95.37 µM -0.546478223934821 0.281794818225164 no 2417 0.292368626216655 3357 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1 SGTC_2458 5808907 16.39 µM -0.54744780685656 0.281447784031902 no 2418 0.292035559383276 3505 2731747 SGTC_1623 st003709 20.3 µM -0.547501180573897 0.281428686441777 no 2419 0.292017229810647 3403 16192618 SGTC_390 dec-rvkr-cmk 16.7 µM -0.547673472763924 0.281367043033436 no 2420 0.29195806497692 3404 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1 SGTC_2254 7938975 95.19 µM -0.548946851148587 0.280911650657369 no 2421 0.291520962269621 3515 2969277 SGTC_101 0490-5701 117.494 µM -0.549467444198377 0.280725576044239 no 2422 0.291342350269615 3412 4661669 SGTC_293 4049-0273 38.5 µM -0.549838288924664 0.280593062066025 no 2423 0.291215147073992 3374 1380311 SGTC_2928 9011484 9.79 µM -0.551305059239064 0.280069237703252 no 2424 0.290712285456547 3435 2994751 SGTC_2374 9071832 200 µM -0.551979443872192 0.279828555408655 no 2425 0.290481218508435 3444 17381698 SGTC_1681 tripelennamine 100 µM -0.553289978868758 0.279361123443735 no 2426 0.29003243097237 3454 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist. SGTC_631 k072-0230 41.5 µM -0.555598520466401 0.278538653610756 no 2427 0.289242671557351 3449 5773147 SGTC_3337 9144342 33.5465 µM -0.556512311224894 0.278213421270571 no 2428 0.288930340331557 3435 17682949 SGTC_2244 6635614 200 µM -0.557429549336615 0.277887148299056 no 2429 0.288616990500853 3228 836499 SGTC_3004 9076122 71.4286 µM -0.557886674659938 0.277724612918638 no 2430 0.288460885672277 3461 44782551 SGTC_3234 9132280 49.47 µM -0.558300917310666 0.277577365003407 no 2431 0.288319459329711 3459 17612295 SGTC_68 0986-0284 82.829 µM -0.558616690706117 0.27746514488868 no 2432 0.288211673284497 3435 423278 YIL048W NEO1 SGTC_1917 st066507 28.5 µM -0.559462463935899 0.2771646817714 no 2433 0.287923070846039 3331 3156428 SGTC_1278 0874-0585 172 µM -0.56049472740738 0.276798183362567 no 2434 0.287571017527308 3426 766306 SGTC_2448 5185112 27.17 µM -0.560974265634638 0.276628007236211 no 2435 0.287407540334555 3451 5718189 SGTC_1764 st044502 93.5 µM -0.562031994920937 0.276252826946491 no 2436 0.287047110155882 3476 8407 SGTC_711 k292-0785 179 µM -0.56242627652695 0.276113037788906 no 2437 0.286912810162815 3469 4146315 SGTC_2457 5731572 11.68 µM -0.562764488679118 0.275993155250261 no 2438 0.286797632244454 3472 2865357 SGTC_473 2-arachidonoylglycerol 10 µM -0.563877644184702 0.275598767224327 no 2439 0.286418702741923 3346 5282280 An endocannabinoid. SGTC_1144 3486-0183 12.5 µM -0.564168565222729 0.27549574037151 no 2440 0.286319709427534 3418 6744069 SGTC_1182 1222-0449 220 µM -0.564444555184837 0.275398018727964 no 2441 0.286225811809995 3440 658318 SGTC_3165 9101544 49.47 µM -0.564975983892699 0.275209900201273 no 2442 0.286045049733969 3461 5002184 SGTC_971 1315-0384 26.7 µM -0.565094378358448 0.275167998791156 no 2443 0.286004786003804 3417 6769120 SGTC_1803 st050068 52.4 µM -0.565435587666984 0.275047257755216 no 2444 0.285888762207573 3526 3984059 YIL048W | YNL267W NEO1 | PIK1 SGTC_856 0433-0016 11.3 µM -0.566151298705946 0.274794079568921 no 2445 0.28564546668402 3444 3911780 SGTC_2058 5236698 133 µM -0.566347357082036 0.274724745228441 no 2446 0.285578836694645 3387 766665 SGTC_2822 7994718 71.43 µM -0.566550475386602 0.274652923304296 no 2447 0.285509815207178 3429 1018011 SGTC_1089 terbinafine 2.25 µM -0.56800870304914 0.274137571141793 no 2448 0.285014529199966 3472 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_2683 piperine 63.03 µM -0.568099158787577 0.274105618925793 no 2449 0.28498381947172 3396 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_3335 9143315 29.6265 µM -0.568700626914143 0.273893205582244 no 2450 0.284779661149615 3390 4899691 SGTC_2213 7173844 200 µM -0.569119525225722 0.273745316338451 no 2451 0.284637514350262 3412 892728 SGTC_1415 3966-0071 78.1 µM -0.569240186951579 0.273702724852124 no 2452 0.284596575905615 3466 2893185 SGTC_38 0929-0051 58.268 µM -0.569989803104501 0.273438196879796 no 2453 0.284342307071556 3436 1379719 SGTC_707 0865-0008 204 µM -0.570992723258714 0.273084479906322 no 2454 0.284002287739267 3448 723043 SGTC_2800 7887935 81.82 µM -0.572679737922883 0.272490003686212 no 2455 0.283430779543094 3479 2961002 SGTC_1674 st016616 23.6 µM -0.573849195189903 0.27207828365041 no 2456 0.283034927544665 3412 625830 SGTC_471 1-acyl-paf 4 µM -0.575965416039776 0.271334032429338 no 2457 0.282319278922187 3408 16759367 SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM -0.576439514249964 0.271167436602615 no 2458 0.282159071187511 3442 2724278 An inhibitor of dopamine biosynthesis. SGTC_3145 9085516 49.47 µM -0.57700278006663 0.270969574023323 no 2459 0.281968788750844 3450 25236195 SGTC_1822 st052468 42 µM -0.577067644106541 0.270946793374707 no 2460 0.28194688035283 3400 2873678 SGTC_171 k064-0041 9.68 µM -0.578019743715457 0.2706125201491 no 2461 0.281625394755936 3395 53325 SGTC_1585 2',4'-dihydroxychalcone 10.4 µM -0.578914829941446 0.27029845174685 no 2462 0.281323321577978 3515 5357218 A potent inhibitor of glutathione S-transferases. SGTC_550 4123-0385 25.7 µM -0.579533350040282 0.27008153155986 no 2463 0.281114675195238 3450 5731123 SGTC_3123 9126162 49.47 µM -0.579729348004167 0.270012811605863 no 2464 0.281048574485365 3478 25239884 SGTC_2654 protoveratrine a 100 µM -0.580790961698921 0.269640745335973 no 2465 0.280690673670332 3441 5702278 A heart drug and vasodilator. SGTC_2603 homopterocarpin 100 µM -0.581264831387978 0.269474750051595 no 2466 0.28053098962941 3474 101795 A weak amylase inhibitor. SGTC_2478 5763493 32.33 µM -0.581812161854739 0.269283085420202 no 2467 0.280346605597782 3446 1365576 YLR208W SEC13 SGTC_2224 6650123 117.647 µM -0.582215159430678 0.269142007113951 no 2468 0.280210881781457 3459 2908370 SGTC_312 4092-0653 6.84 µM -0.5826715472431 0.268982283154001 no 2469 0.280057215346717 3479 1148278 SGTC_1253 0550-0034 176 µM -0.583678323648439 0.268630105726736 no 2470 0.279718376788688 3482 5969915 SGTC_883 0850-0245 24.6 µM -0.584061423446425 0.268496155626884 no 2471 0.279589493794297 3545 6823229 YPR165W RHO1 SGTC_3107 9121808 49.47 µM -0.584941430378542 0.268188590123988 no 2472 0.279293549787156 3468 662681 SGTC_1842 st055362 61.2 µM -0.585635704716332 0.267946063986164 no 2473 0.279060174628488 3468 676032 SGTC_2159 5658611 73.75 µM -0.585807346424536 0.267886122586244 no 2474 0.279002493167286 3522 793844 SGTC_2623 humulene 100 µM -0.58630862493847 0.267711102783984 no 2475 0.278834068033483 3454 6187145 An anti-inflammatory. SGTC_1226 3909-7979 35.4 µM -0.586446723068188 0.26766289638639 no 2476 0.278787676981503 3509 6615510 SGTC_2811 7967822 32.47 µM -0.586911176011291 0.267500800278791 no 2477 0.278631681723005 3496 2232244 SGTC_3088 9117578 49.47 µM -0.587203420633373 0.267398831006933 no 2478 0.278533547660643 3528 678341 SGTC_1438 4092-1045 4 µM -0.587326123276665 0.267356023748633 no 2479 0.278492349838086 3482 1351342 SGTC_3250 9135583 49.47 µM -0.587398846989173 0.267330654266488 no 2480 0.278467934009785 3514 7699353 SGTC_650 1328-0195 38 µM -0.588158493315829 0.267065726202147 no 2481 0.278212957216621 3499 2780821 SGTC_3153 9100258 49.47 µM -0.58968574573977 0.26653349557562 no 2482 0.277700676694106 3421 25236848 SGTC_1159 4092-0538 61.2 µM -0.590893455694566 0.266113002125688 no 2483 0.277295905576006 3530 717301 SGTC_689 0833-0039 98 µM -0.591594238111329 0.265869161877021 no 2484 0.277061166575847 3483 5374726 SGTC_999 SEC7.066 22.7 µM -0.592520054235143 0.265547193879372 no 2485 0.276751197897134 3497 740511 YDR170C SEC7 SGTC_2823 7987624 58.44 µM -0.592565402844788 0.265531428226681 no 2486 0.276736019281942 3582 2239440 SGTC_1889 st059080 5.18 µM -0.592670579321297 0.265494864968702 no 2487 0.276700817275127 3533 176925 Isolated from Daphnopsis sellowiana. SGTC_2972 9093619 59.92 µM -0.59304602625335 0.265364366477165 no 2488 0.276575175083965 3396 25236256 SGTC_2626 ethyl orsellinate 100 µM -0.593309190957373 0.265272914646793 no 2489 0.276487124478222 3469 75653 A natural product. SGTC_370 0180-0345 38.7 µM -0.593487869156517 0.265210831670663 no 2490 0.276427349510344 3436 3989527 SGTC_1745 st081495 74 µM -0.593784547080094 0.265107765171448 no 2491 0.276328112939048 3494 13842402 YBL026W LSM2 SGTC_334 1502-1024 68.5 µM -0.595317685377331 0.264575474298412 no 2492 0.275815568213361 3529 3296216 SGTC_2625 euphol 100 µM -0.596313624307333 0.264229985435211 no 2493 0.275482865535022 3534 6708538 A triterpene alcohol. SGTC_644 1498-1197 63.3 µM -0.596493814197995 0.264167502540957 no 2494 0.275422692519138 3545 6741615 SGTC_147 4466-0538 29.23 µM -0.596718443244983 0.264089620404167 no 2495 0.275347688448246 3597 6742687 YHR072W ERG7 SGTC_380 3970-0968 6 µM -0.597375087077866 0.263862019598574 no 2496 0.275128491464316 3469 2891601 SGTC_1431 4049-0260 9.09 µM -0.598986328773566 0.263303967531756 no 2497 0.274591000624338 3496 3854841 SGTC_1167 k781-0610 148 µM -0.59941321800873 0.263156215903796 no 2498 0.274448682358994 3509 4525169 SGTC_773 4358-1457 44.6 µM -0.600540986295112 0.262766085266231 no 2499 0.274072877069411 3542 1186886 SGTC_1487 3970-0795 2.82 µM -0.600639677527445 0.262731958937033 no 2500 0.274040002374699 3531 3765103 SGTC_2497 7-hydroxyflavone 100 µM -0.603093030978107 0.261884345957377 no 2501 0.273223401152414 3531 5281894 SGTC_3304 9125678 46.087 µM -0.603486291568061 0.261748608259918 no 2502 0.273092616156031 3504 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2 SGTC_3318 9139014 38.6185 µM -0.606640413166874 0.260661239862309 no 2503 0.272044787144679 3526 16643984 SGTC_830 4076-0286 57.8 µM -0.606891282975098 0.260574853611428 no 2504 0.271961531728981 3569 6866659 SGTC_571 k831-0106 44.2 µM -0.608536699481064 0.260008625052127 no 2505 0.271415786597639 3517 4783639 SGTC_1627 st003713 25.6 µM -0.609196116499581 0.259781881551101 no 2506 0.271197227063822 3525 16195070 YER133W GLC7 SGTC_1124 fisetin 1.16336 µM -0.60949860339147 0.259677904223787 no 2507 0.271096999092381 3486 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster. SGTC_2096 5468907 200 µM -0.60981300287529 0.259569854814554 no 2508 0.270992843508113 3517 759785 SGTC_1609 st001574 46.4 µM -0.609978883732597 0.25951285603452 no 2509 0.270937897845805 3450 3960012 SGTC_594 1487-1584 10.8 µM -0.610039636110515 0.259491982359207 no 2510 0.270917775880045 3459 5013332 SGTC_2161 5662504 8.5105 µM -0.610094641049878 0.259473084172108 no 2511 0.2708995581828 3496 2859334 SGTC_2793 7325131 81.82 µM -0.613812562003283 0.258197358422447 no 2512 0.269669597590765 3483 4176441 SGTC_2987 9018338 71.43 µM -0.613937677257943 0.258154484396871 no 2513 0.26962825573329 3589 5055682 SGTC_561 1550-0330 72.9 µM -0.614460839598784 0.257975249084571 no 2514 0.269455421505507 3466 6812934 SGTC_2846 9008642 19.48 µM -0.615239422638342 0.257708626262296 no 2515 0.269198308226816 3536 2992898 SGTC_3243 9134147 49.47 µM -0.616139369062835 0.257400621341963 no 2516 0.268901270260611 3579 24282180 SGTC_166 k072-0058 166.424 µM -0.616167662712029 0.257390940997556 no 2517 0.268891934275888 3566 5846229 SGTC_4 0960-0234 25.671 µM -0.616618179828611 0.257236827274386 no 2518 0.268743300200449 3542 6821112 SGTC_1198 1612-1005 86.7 µM -0.617336930839747 0.256991054956904 no 2519 0.2685062561951 3617 6998509 SGTC_1734 st037168 69.4 µM -0.619640784332897 0.256204091064649 no 2520 0.267747154671215 3490 708907 SGTC_2409 alverine citrate 63.97 µM -0.619750569007037 0.256166621555706 no 2521 0.267711008499601 3621 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_469 w7 172 µM -0.62091222080455 0.25577032495131 no 2522 0.267328689955174 3557 45115570 A P450 inhibitor. SGTC_2389 9091542 195.52 µM -0.622085204660918 0.255370487419551 no 2523 0.266942921553968 3505 3626624 YOL127W RPL25 SGTC_3257 9139206 32.98 µM -0.623405006640803 0.254920994559641 no 2524 0.266509204367266 3519 4910041 SGTC_1713 st033146 12.748 µM -0.623741300499312 0.254806527173578 no 2525 0.26639874750239 3579 674619 SGTC_3121 9125696 49.47 µM -0.625156444783022 0.254325136700515 no 2526 0.265934192487223 3589 1235365 SGTC_2875 9039966 71.43 µM -0.625569073330943 0.25418486242638 no 2527 0.265798814609729 3542 6463691 SGTC_2125 5246583 200 µM -0.626462155185918 0.253881395651745 no 2528 0.265505926132866 3614 835267 SGTC_1808 st050063 61.5 µM -0.629438666907216 0.252871359771481 no 2529 0.264530955145142 3570 4011993 SGTC_2836 9010338 19.48 µM -0.630287101810339 0.252583843614522 no 2530 0.264253380140425 3469 2994051 SGTC_3005 9076496 71.4286 µM -0.630456888489731 0.2525263272843 no 2531 0.264197850337741 3580 21368410 SGTC_1925 st057770 10.1 µM -0.63121033603188 0.252271175361127 no 2532 0.263951502299389 3452 5989122 SGTC_1281 0884-0031 11.8 µM -0.631595251553768 0.252140877776226 no 2533 0.263825695095705 3573 1548255 SGTC_751 0833-0568 350 µM -0.633551176443406 0.25147932735777 no 2534 0.26318688617213 3570 6954252 SGTC_947 3447-0010 211 µM -0.634256086521148 0.251241131411736 no 2535 0.262956855008732 3591 748350 SGTC_564 3555-0129 330 µM -0.63448983106065 0.251162173214145 no 2536 0.262880600560786 3496 563260 SGTC_2979 9012552 45.46 µM -0.636220304154716 0.25057803313194 no 2537 0.262316420489253 3640 17100905 SGTC_2144 5628481 200 µM -0.636559980146223 0.250463456356281 no 2538 0.262205749974168 3559 2818399 SGTC_1960 st011366 51.8 µM -0.636908749070721 0.250345841320605 no 2539 0.262092141768837 3585 3972846 SGTC_57 miconazole 162.5 nM -0.63740888573758 0.250177231785991 no 2540 0.261929270980624 3528 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_2300 7976697 71.57 µM -0.637485026221433 0.250151568062665 no 2541 0.261904480189427 3497 2236109 SGTC_412 gemfibrozil 100 µM -0.637826284550066 0.250036561530241 no 2542 0.26179338372765 3568 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels. SGTC_2622 2-methoxyxanthone 59.94 µM -0.637849427590267 0.250028763173697 no 2543 0.261785850398988 3569 71034 A hepatoprotective. SGTC_2453 5731132 22.18 µM -0.638289903466155 0.24988036354885 no 2544 0.261642491582803 3620 1362040 SGTC_2427 5545055 42.75 µM -0.638459141888518 0.24982335829076 no 2545 0.261587421370721 3579 5372858 SGTC_2333 9017922 200 µM -0.641374735888945 0.248842372022268 no 2546 0.260639621602433 3587 3163164 SGTC_3082 9117008 49.47 µM -0.641495541744853 0.248801769745446 no 2547 0.260600388269784 3533 41448529 SGTC_1121 fusaric acid 630.51 nM -0.642175066454885 0.248573450437691 no 2548 0.260379760104465 3565 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler. SGTC_1236 0330-0013 258 µM -0.642931506920012 0.248319418895936 no 2549 0.260134272139858 3547 4617066 SGTC_376 3970-0862 59.1 µM -0.643253408431365 0.248211358348621 no 2550 0.260029841497339 3574 3135186 SGTC_162 k030-0015 37.8 µM -0.643476160127923 0.248136596525778 no 2551 0.259957589496094 3605 1809920 YMR134W ERG29 SGTC_71 0417-1750 47.813 µM -0.644158941045666 0.247907510627825 no 2552 0.259736186405464 3578 6811472 SGTC_2484 5809818 12.04 µM -0.645585378078506 0.24742927853702 no 2553 0.259273954652618 3574 2870548 SGTC_843 0310-0051 143 µM -0.647160168883348 0.246901882011903 no 2554 0.258764143562481 3570 2065037 SGTC_2656 pseudo-anisatin 100 µM -0.647755441683145 0.246702682304859 no 2555 0.258571569572978 3600 6708809 A neurotoxin. SGTC_1428 4049-0204 61.7 µM -0.649056759754472 0.24626751431548 no 2556 0.258150844696083 3625 X1428 SGTC_2115 tiliquinol 12.7705 µM -0.649142649689624 0.246238806728975 no 2557 0.25812308839429 3558 71208 A bioactive hydroxyquinoline. SGTC_559 1550-0661 158 µM -0.649701737268079 0.246051982885856 no 2558 0.257942450761215 3598 5830875 SGTC_3000 9075062 71.4286 µM -0.649895457801489 0.245987267273712 no 2559 0.257879876193548 3570 17057871 SGTC_1815 st051655 58.2 µM -0.650868898961403 0.245662211126179 no 2560 0.257565559726178 3570 5984156 SGTC_2897 9048598 12.99 µM -0.651116309858832 0.245579631270756 no 2561 0.257485704423006 3569 6467404 SGTC_18 0111-0177 500 nM -0.651157546190312 0.245565869016875 no 2562 0.257472396074879 3660 721752 SGTC_1647 st011722 22.4 µM -0.652550192047021 0.245101329364216 no 2563 0.257023152421781 3611 2854783 SGTC_2414 st077232 92.9 µM -0.65411052136877 0.244581418117363 no 2564 0.25652030171884 3563 729801 SGTC_1504 k297-0033 30 µM -0.654720346992285 0.24437838205952 no 2565 0.256323911276418 3498 4388117 SGTC_2406 ethylparaben 405.7 µM -0.65534411308692 0.244170798650181 no 2566 0.256123112499631 3433 8434 A possible steroid mimic. SGTC_1828 st055811 49 µM -0.655791621882435 0.244021930583877 no 2567 0.255979103896767 3579 5877589 SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM -0.656368251213983 0.243830181550617 no 2568 0.255793606532883 3650 5024745 SGTC_1715 st032160 10.2275 µM -0.659332062726347 0.242845896972961 no 2569 0.254841278796222 3549 5289825 SGTC_2697 mebhydrolin 72.4 µM -0.660560607658889 0.242438527285927 no 2570 0.254447069248453 3626 22530 H1 Histamine receptor antagonist. YIL048W NEO1 SGTC_716 1683-5115 658 µM -0.660874884028551 0.242334376781623 no 2571 0.254346277121033 3647 723597 SGTC_2235 salicylic acid 500 µM -0.662024063413115 0.241953747737837 no 2572 0.253977900028788 3620 338 A COX inhibitor and kinase inhibitor. SGTC_1214 0358-0031 63.7 µM -0.662082304997896 0.241934465707268 no 2573 0.253959237758164 3659 4301366 SGTC_3296 9122258 64.045 µM -0.662228574703031 0.241886043899147 no 2574 0.253912371931559 3618 4730474 SGTC_3194 9111903 49.47 µM -0.66249418204356 0.241798129445648 no 2575 0.25382728110599 3638 17087251 SGTC_2495 cafestol 54.53 µM -0.662583252457942 0.241768651549934 no 2576 0.253798749572313 3627 16667697 An anti-infammatory. SGTC_215 1287-0124 461.5 µM -0.66392373676697 0.24132525326794 no 2577 0.253369561560843 3613 5560863 SGTC_2179 6298986 200 µM -0.664309837308606 0.241197622990437 no 2578 0.253246013070172 3582 738374 SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM -0.66725345090808 0.240225782553994 no 2579 0.252305127160964 3630 688761 SGTC_708 3448-5400 146 µM -0.668450593948863 0.239831154419 no 2580 0.251923004572398 3611 3462195 SGTC_1600 coumarin 106 71.1 µM -0.669093324306482 0.2396194297542 no 2581 0.25171797406669 3667 100336 A hepatotoxic, DNA x-linker. SGTC_3 0833-0587 95.581 µM -0.670307117870653 0.239219867032152 no 2582 0.251331015296241 3570 5382644 SGTC_2090 5301565 104.445 µM -0.670347883983939 0.239206453757987 no 2583 0.251318024473475 3647 2056344 SGTC_974 1326-0144 138 µM -0.670384151875333 0.239194520879217 no 2584 0.251306467384844 3653 5411856 SGTC_1472 k841-0093 193 µM -0.671313831325957 0.238888748373411 no 2585 0.251010312637673 3687 X1472 SGTC_2661 dactinomycin 12.96 µM -0.672789979189215 0.238403681351189 no 2586 0.25054045689654 3641 45006140 An Actinomycin D Classic transcription inhibitor. SGTC_1988 st071872 53.4 µM -0.673294285803489 0.238238088234613 no 2587 0.250380043686373 3645 16414116 SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM -0.673298181909575 0.238236809162299 no 2588 0.250378804598934 3611 5355888 SGTC_1835 st008666 49.2 µM -0.674407303248312 0.237872843139932 no 2589 0.250026200436952 3573 690455 SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM -0.674763992806414 0.237755857765448 no 2590 0.249912860183838 3645 6708739 YPR165W RHO1 SGTC_3263 9137018 49.47 µM -0.675306793402917 0.237577893132319 no 2591 0.249740434367107 3593 43844957 SGTC_488 nitrendipine 139 µM -0.675587332278366 0.2374859432704 no 2592 0.249651343270252 3665 4507 Dihydropyridine L-type calcium channel blocker. SGTC_1885 st057546 99.9 µM -0.675925528615975 0.237375121482403 no 2593 0.249543964263523 3683 702008 SGTC_1394 3474-0001 65.7 µM -0.677121652363042 0.236983397854664 no 2594 0.249164386021536 3583 5017666 YIL048W NEO1 SGTC_939 1165-0479 45.3 µM -0.678086785409346 0.23666758153633 no 2595 0.248858334435142 3591 1377347 SGTC_945 3381-0768 11.3 µM -0.679626857220071 0.236164110322147 no 2596 0.248370379797319 3646 1126236 YIL048W NEO1 SGTC_2981 9013952 38.96 µM -0.680209284373258 0.23597386052057 no 2597 0.248185977220258 3559 2996344 SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM -0.680488437566236 0.235882705094574 no 2598 0.248097620267734 3781 16725076 SGTC_1481 3346-2004 36 µM -0.680496735556237 0.23587999574395 no 2599 0.248094994063088 3651 2770522 SGTC_3115 9123671 49.47 µM -0.681138409714078 0.235670536692208 no 2600 0.247891957554825 3724 3286988 SGTC_2776 terbinafine 19.92 µM -0.68234729008359 0.235276205680589 no 2601 0.247509688507418 3657 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_230 MPP+ 141.667 µM -0.682843236399991 0.235114535797026 no 2602 0.247352952798774 3621 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death. SGTC_3354 9151612 71.43 µM -0.683762973884855 0.234814879829854 no 2603 0.247062425318571 3647 27261949 SGTC_1781 st038725 66.3 µM -0.684347817048991 0.234624444286818 no 2604 0.246877779539312 3667 4270275 YIL048W NEO1 SGTC_395 anisomycin 6.25 µM -0.684356705593243 0.23462155067465 no 2605 0.246874973831791 3610 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_2003 4023581 200 µM -0.688054898685715 0.23341933996343 no 2606 0.245709105322501 3681 16641307 SGTC_2242 6630449 61.2675 µM -0.688184344465757 0.233377321649521 no 2607 0.24566835070011 3663 691249 YDR170C SEC7 SGTC_3302 9125395 16.351 µM -0.688723462512579 0.23320236818453 no 2608 0.24549865418617 3625 17599668 SGTC_592 k241-0073 46.5 µM -0.689635043363492 0.232906709555394 no 2609 0.245211862041606 3667 4230158 SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM -0.689914942033258 0.232815970097014 no 2610 0.245123839376548 3673 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_1911 st060208 74.3 µM -0.690025676078299 0.232780077002974 no 2611 0.24508902037398 3678 688783 SGTC_2086 5274770 176.623 µM -0.69002591813456 0.232779998546749 no 2612 0.245088944265184 3666 689278 SGTC_1389 3405-0187 19 µM -0.69069168548393 0.232564263029276 no 2613 0.244879657769977 3613 799890 SGTC_1872 amphotericin b 148 nM -0.69121173723679 0.232395822611761 no 2614 0.244716244456237 3672 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1 SGTC_397 arbidol 50 µM -0.692681344837698 0.23192019601001 no 2615 0.24425477442318 3695 131410 A RNA synthesis inhibitor. SGTC_1539 benzyladenosine 56 µM -0.693124743897202 0.231776800021137 no 2616 0.244115635299248 3652 92208 A nucleotide analog. SGTC_1164 k060-0068 93.7 µM -0.696647597533104 0.230639260238917 no 2617 0.243011680330934 3698 5963676 SGTC_2007 4011539 71.82 µM -0.698003145399978 0.230202382339065 no 2618 0.242587613496154 3679 45595301 SGTC_349 k015-0014 24 µM -0.700386624445911 0.22943533741569 no 2619 0.241842943556968 3657 2196908 SGTC_439 amiodarone 34.4 µM -0.702082240911195 0.228890531736426 no 2620 0.24131393839428 3608 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1 SGTC_2815 7968870 71.43 µM -0.703736477371698 0.228359721949477 no 2621 0.240798449657702 3681 2977326 YHR190W ERG9 SGTC_2633 5,7-dihydroxyisoflavone 100 µM -0.70500036610363 0.227954633178324 no 2622 0.240405004165116 3691 5377381 SGTC_82 0054-0107 293.755 µM -0.705525874180661 0.227786321725809 no 2623 0.240241517899072 3681 3104697 SGTC_3303 9125618 40.5795 µM -0.707408995261797 0.227183764229441 no 2624 0.239656174253283 3709 22695467 SGTC_2042 p-Dimethylaminoacetophenone 200 µM -0.707937382417587 0.227014853463469 no 2625 0.239492071946611 3669 75037 A free radical scavenger. SGTC_110 0850-0284 111.64 µM -0.708676724099971 0.226778625278112 no 2626 0.239262556074542 3547 3906265 SGTC_1548 st061468 90.8 µM -0.708938308775519 0.226695079188394 no 2627 0.239181380413948 3692 390799 SGTC_1949 st076024 69.1 µM -0.70901684885593 0.226669998095298 no 2628 0.239157010582871 3669 2921930 SGTC_2872 9044037 25.97 µM -0.709347713548385 0.226564356523852 no 2629 0.239054363038768 3685 6465195 SGTC_649 1123-0311 367 µM -0.709505707853084 0.226513920432182 no 2630 0.239005355343919 3665 693629 YIL048W NEO1 SGTC_1643 st009866 20.2 µM -0.710835183908611 0.226089766591763 no 2631 0.238593187522655 3682 3156273 YOR207C RET1 SGTC_912 3474-0017 2.18 µM -0.710865083486902 0.226080232643919 no 2632 0.238583922448284 3722 3360550 SGTC_2652 actinonin 100 µM -0.711811046266513 0.225778714970711 no 2633 0.238290895742652 3677 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase. SGTC_2076 5212012 200 µM -0.712711249834073 0.225491993997769 no 2634 0.238012226824863 3609 604802 SGTC_1488 4013-0813 75.9 µM -0.713423837570513 0.225265176165506 no 2635 0.23779176339308 3668 2910057 SGTC_220 paclitaxel 373.376 µM -0.714603232082611 0.224890057039322 no 2636 0.237427123513646 3648 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_3189 9110682 49.47 µM -0.716868121722131 0.224170678396344 no 2637 0.236727736752616 3758 17122418 SGTC_72 0744-0168 198.391 µM -0.717905306594545 0.223841682468541 no 2638 0.236407837834582 3631 677577 SGTC_2203 7227154 166.4 µM -0.71864978204548 0.223605703500092 no 2639 0.236178366063993 3712 896304 SGTC_1264 0783-0040 158 µM -0.718692803096092 0.223592071293631 no 2640 0.236165109314766 3639 2855798 SGTC_1642 st009582 77.7 µM -0.721031623280266 0.222851674129671 no 2641 0.23544502922587 3705 6739311 SGTC_2921 7974240 10.71 µM -0.721190526954352 0.222801420935058 no 2642 0.235396149677746 3728 2979074 YDR527W RBA50 SGTC_643 k048-0106 28.4 µM -0.721543940536516 0.222689677249366 no 2643 0.23528745801263 3732 6763920 SGTC_2419 paclitaxel 166.5 µM -0.721824927489786 0.222600856497434 no 2644 0.235201060793207 3661 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_2120 5538279 151.968 µM -0.72663302901474 0.221084135214965 no 2645 0.23372539464291 3726 2058197 SGTC_1015 4130-4525 82 µM -0.73011143387026 0.219990564800481 no 2646 0.232661036440996 3741 1363237 SGTC_198 3454-2873 16.191 µM -0.732171931090208 0.219344234686915 no 2647 0.232031817102293 3724 710957 SGTC_1391 3442-0225 151 µM -0.73227410618414 0.219312213156221 no 2648 0.232000640305024 3685 5227075 SGTC_1591 genipin 88.4 µM -0.73233526225841 0.219293048213917 no 2649 0.231981980801613 3735 442424 A DNA cross-linking agent. SGTC_686 1319-0111 510 µM -0.734376576477668 0.218653898599185 no 2650 0.231359629305851 3759 4562600 SGTC_1546 5-methoxyflavanone 78.7 µM -0.735571229125975 0.218280342536 no 2651 0.230995838544178 3756 147795 SGTC_1348 1493-0373 93.8 µM -0.737048156958939 0.217819030487327 no 2652 0.230546532232431 3734 3010129 SGTC_1752 st044819 83.042 µM -0.737763797310905 0.217595705709975 no 2653 0.230328998178397 3731 441209 YML126C ERG13 SGTC_1471 k673-0312 37 µM -0.739200884722336 0.217147643421264 no 2654 0.229892511848606 3727 24099884 SGTC_2728 chlorpromazine 9.18 µM -0.740291482281042 0.216807967500625 no 2655 0.229561574102202 3745 2726 A thorazine and dopamine antagonist. SGTC_539 4859-0462 2.54 µM -0.740979152798931 0.21659394467108 no 2656 0.229353040342345 3785 46499474 YNL221C | YBR257W POP1 | POP4 SGTC_2958 9077254 16.72 µM -0.74148024818068 0.216438066394205 no 2657 0.229201151767266 3742 16457351 SGTC_2522 biochanin a 4.94 µM -0.742552267440587 0.21610480603486 no 2658 0.228876398183923 3698 5280373 A possible chelator. SGTC_982 1491-0518 27.5 µM -0.744446499343944 0.215516670195999 no 2659 0.228303198330241 3713 3091256 SGTC_428 3448-4153 16.5 µM -0.745499417377559 0.21519015385678 no 2660 0.227984931614441 3723 3834874 SGTC_2911 7942208 15.64 µM -0.745690113762603 0.215131048464541 no 2661 0.227927316309391 3744 1243384 SGTC_2564 betulinic acid 100 µM -0.746250832180772 0.214957311196676 no 2662 0.227757953309659 3750 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14 SGTC_1895 st058434 18.3 µM -0.746780531696613 0.214793259935744 no 2663 0.227598024540324 3739 5393175 SGTC_2017 5132927 60.65 µM -0.748332958200004 0.214312882912514 no 2664 0.22712967478796 3760 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis SGTC_3148 9097893 49.47 µM -0.748711157229964 0.214195949158271 no 2665 0.227015658716057 3726 17174100 SGTC_2019 4016004 108 µM -0.748799978999879 0.214168492115609 no 2666 0.226988886201289 3763 45595336 SGTC_2963 9082507 9 µM -0.749452191064111 0.213966939703979 no 2667 0.226792352038169 3780 16459611 SGTC_182 3448-4371 550.524 µM -0.749479861880102 0.213958391063082 no 2668 0.226784015983128 3737 3491403 SGTC_761 k216-0224 480 µM -0.749998209156877 0.213798289250998 no 2669 0.22662789166713 3773 1340404 SGTC_804 1595-0054 20.9 µM -0.750832573465334 0.21354072591761 no 2670 0.226376711632355 3717 761523 Stimulates phospholipase C. SGTC_2030 5175110 200 µM -0.7519106374343 0.21320820182522 no 2671 0.226052400321294 3794 2831986 SGTC_848 0368-0089 85.6 µM -0.752703000291422 0.212963993639195 no 2672 0.225814203307471 3741 762535 SGTC_2903 5923464 63.88 µM -0.75293018200533 0.212894005793984 no 2673 0.225745935026247 3777 2876576 SGTC_1861 st057647 17.4 µM -0.75346307310429 0.212729890775093 no 2674 0.22558584665742 3788 688668 SGTC_213 1246-0773 967 nM -0.754678929699863 0.212355718814365 no 2675 0.225220825971056 3733 6251622 SGTC_1522 st012842 45.6 µM -0.754829180184051 0.212309506919254 no 2676 0.225175741474939 3668 3491067 YOR116C RPO31 SGTC_1657 st012939 43.4 µM -0.758206500238089 0.211272310866699 no 2677 0.224163685223413 3771 24207257 SGTC_2674 ligustilide 100 µM -0.759218422690087 0.210962122096428 no 2678 0.223860953695105 3779 5319022 A signalling regulator. SGTC_1016 4226-1401 38 µM -0.760631851739244 0.210529305080147 no 2679 0.223438494735409 3764 2901613 SGTC_2385 9074692 200 µM -0.761302931044623 0.210323991294191 no 2680 0.223238075150537 3781 17046906 SGTC_3066 9117245 49.47 µM -0.761307046984947 0.210322732403057 no 2681 0.223236846230036 3848 17176980 SGTC_201 4262-0159 12.803 µM -0.7619685917707 0.210120451490991 no 2682 0.223039374969046 3769 1341029 SGTC_1797 st048695 56.8 µM -0.763129278915172 0.209765823834377 no 2683 0.222693150098595 3731 592262 YIL048W NEO1 SGTC_1940 st075990 51.1 µM -0.764027071843072 0.209491760424399 no 2684 0.222425554979908 3849 1084979 SGTC_1879 gemcitabine 100 µM -0.764285571411954 0.20941288901724 no 2685 0.222348540916267 3773 60750 A nucleoside analog which inhibits DNA replication. SGTC_457 grayanotoxin iii 135 µM -0.764360976375168 0.209389885324975 no 2686 0.222326078589698 3709 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity. SGTC_2353 9059630 146.67 µM -0.768226123578339 0.208212742753774 no 2687 0.221176427984103 3824 4779114 SGTC_1867 st057372 64 µM -0.768545362899704 0.208115692315362 no 2688 0.221081625635327 3764 688837 SGTC_1006 4099-6547 255 µM -0.771351741593138 0.207263687966998 no 2689 0.22024923557236 3817 3146833 SGTC_3310 9130229 44.1445 µM -0.771495747616466 0.207220024074543 no 2690 0.220206570982584 3870 7761258 SGTC_933 2914-0560 114 µM -0.772182133316494 0.207011980668549 no 2691 0.220003280989195 3806 463887 SGTC_1303 1160-0052 261 µM -0.773138325790703 0.206722364968837 no 2692 0.219720260650875 3779 3562476 SGTC_2563 tomatine 8.54 µM -0.773487647238753 0.206616620842597 no 2693 0.219616918273282 3733 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties. SGTC_118 0083-0097 135.343 µM -0.775607716852613 0.205975535832006 no 2694 0.218990321305189 3848 5207356 SGTC_3227 9130768 49.47 µM -0.775690676989334 0.205950473637323 no 2695 0.218965822953427 3817 17720899 SGTC_1473 k844-0725 134 µM -0.775899689851526 0.205887339029245 no 2696 0.218904107881762 3856 54682906 SGTC_2078 5212016 200 µM -0.777124203095325 0.205517692220579 no 2697 0.218542747866892 3706 1899708 SGTC_1114 scopoletin 1.73284 µM -0.777952074575667 0.205268004040308 no 2698 0.218298633556161 3792 5280460 A coumarin with genotoxic properties. SGTC_1669 st015249 58.4 µM -0.780575960088747 0.20447782502237 no 2699 0.217525967713953 3873 722793 SGTC_2809 7964133 12.99 µM -0.782935064763386 0.20376893224184 no 2700 0.216832622522523 3834 1253665 SGTC_1537 2',6'-dihydroxyflavanone 78 µM -0.785579799867833 0.202975954090487 no 2701 0.21605685128147 3818 5106787 A p450 inhibitor. SGTC_2023 5144124 124 µM -0.786268156953998 0.202769864757222 no 2702 0.215855201803363 3812 2830192 SGTC_1706 st031321 9.9705 µM -0.786645754321758 0.202656867847054 no 2703 0.215744633588865 3843 6103185 SGTC_2945 9067681 61.76 µM -0.788214433228506 0.202187840026722 no 2704 0.215285644042502 3895 16456930 SGTC_3113 9123498 49.47 µM -0.789692469747907 0.201746508643264 no 2705 0.214853695067441 3856 8897275 SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM -0.79025610520027 0.201578363096103 no 2706 0.214689108042742 3777 4620898 SGTC_2147 5545932 89.7195 µM -0.790469563940655 0.201514705321411 no 2707 0.214626795151808 3852 797404 SGTC_1649 st011737 51.3 µM -0.79056744210091 0.201485520074787 no 2708 0.214598226067717 3819 1761035 SGTC_1612 st002233 45.4 µM -0.791127831435621 0.201318472314866 no 2709 0.214434699862783 3821 1035021 SGTC_980 1473-0395 201 µM -0.792799092330771 0.200820775509329 no 2710 0.213947442714724 3737 768876 SGTC_2276 7947513 42.08 µM -0.793426179637352 0.20063422134166 no 2711 0.213764781452784 3704 2105100 SGTC_1784 st039334 36.3 µM -0.793773249244081 0.200531015260815 no 2712 0.213663724265519 3862 3496984 SGTC_1937 st074714 47.2 µM -0.794303777502121 0.200373316769703 no 2713 0.213509302730166 3787 17250970 SGTC_1693 xanthone 101.9 µM -0.796834739155743 0.199622019404469 no 2714 0.212773508312291 3873 7020 An insecticide. SGTC_3108 9121785 49.47 µM -0.798783311525649 0.199044756576267 no 2715 0.212208034461139 3718 17140271 SGTC_3135 9127742 49.47 µM -0.798952494975982 0.198994683630154 no 2716 0.212158979067891 3906 3643468 SGTC_2394 5221648 200 µM -0.799845037725165 0.19873064490655 no 2717 0.211900292627929 3921 788586 SGTC_586 0957-0265 8.15 µM -0.80036504123617 0.198576910982209 no 2718 0.211749664662865 3691 6752309 YPR165W | YPR107C RHO1 | YTH1 SGTC_1071 trifluoperazine 6.31 µM -0.803638277080241 0.197610858883451 no 2719 0.210802955145546 3931 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. SGTC_1564 D-Arginine 115 µM -0.80451028447829 0.197353977484491 no 2720 0.210551166094238 3837 71070 D-isomer of arginine; arginine decarboxylase inhibitor. SGTC_1975 st070967 30.8 µM -0.804876780568251 0.197246073078954 no 2721 0.21044539434357 3796 261391 SGTC_2472 5377652 49.4 µM -0.805066506509083 0.197190227666273 no 2722 0.210390651184794 3905 1610903 SGTC_1741 st038134 10.228 µM -0.805685349310311 0.197008139152377 no 2723 0.210212149586898 3887 1272587 SGTC_763 3453-1109 128 µM -0.807850626625156 0.196371828683937 no 2724 0.209588288436875 3837 1560353 SGTC_225 nsc-122657 1.016 µM -0.808922266308241 0.196057367087987 no 2725 0.209279930174845 3856 275685 SGTC_2034 5197015 53.07 µM -0.809534345806458 0.195877895810761 no 2726 0.209103927637992 3835 780676 SGTC_769 0302-0231 76 µM -0.810852667615519 0.19549168198689 no 2727 0.208725142345983 3821 571869 YER009W NTF2 SGTC_2415 st077333 57.7 µM -0.812712932686514 0.194947488558755 no 2728 0.208191332315154 3837 2766255 SGTC_326 k292-0812 17.5 µM -0.814344945997147 0.194470826192043 no 2729 0.207723684045302 3804 3579357 SGTC_1541 2',3',6-trimethoxyflavone 64 µM -0.816995510499683 0.193698188742661 no 2730 0.206965496842673 3937 688801 SGTC_3356 9151811 4.48 µM -0.81740113513839 0.193580114831938 no 2731 0.206849613605061 3842 1859254 YPR165W RHO1 SGTC_2456 5770359 74.46 µM -0.817719281532369 0.193487535824419 no 2732 0.206758748980786 3858 3118787 SGTC_1980 st071811 45.7 µM -0.819094150419771 0.193087766509365 no 2733 0.20636634953499 3981 4974850 SGTC_3104 9120930 49.47 µM -0.819522026608393 0.192963456323381 no 2734 0.2062443200779 3885 17014836 SGTC_810 3825-7150 143 µM -0.820864123589435 0.192573856225911 no 2735 0.205861834218771 3875 22330411 YGL099W LSG1 SGTC_2586 curcumin 80 µM -0.821367591211008 0.192427827674338 no 2736 0.205718458979958 3871 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40 SGTC_3018 9082602 49.47 µM -0.821637440503461 0.19234958696046 no 2737 0.205641636915149 3857 17332089 SGTC_1220 1838-0075 193 µM -0.8225129209641 0.192095882149267 no 2738 0.205392517966309 3786 5529645 SGTC_2376 9072922 81.32 µM -0.823398475381855 0.191839466419494 no 2739 0.205140714893407 3912 17087968 SGTC_1583 clindamycin 39.6 µM -0.824543511639427 0.191508227520471 no 2740 0.204815401523891 3830 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis. SGTC_1180 1193-0155 285 µM -0.826356866844674 0.190984373058754 no 2741 0.204300841852203 3903 2921347 SGTC_1834 st055981 52.8 µM -0.826652909040081 0.190898933896791 no 2742 0.204216909738915 3931 471719 YDL150W RPC53 SGTC_1962 st076595 64.5 µM -0.828265626243289 0.190433908089378 no 2743 0.203760042541551 3888 279619 SGTC_344 k064-0035 6.43 µM -0.830576946413289 0.189768654772303 no 2744 0.203106331314783 3839 5088750 SGTC_2950 9072895 21.46 µM -0.831552749441904 0.189488224869197 no 2745 0.202830721041393 3826 17332245 SGTC_1327 1436-0082 2.18 µM -0.837104720557574 0.187897536473151 no 2746 0.201266853606635 3892 15992205 SGTC_3294 9122953 26.2835 µM -0.837149855374253 0.187884638832805 no 2747 0.201254169822273 3884 16459826 SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM -0.838103296214335 0.187612313130958 no 2748 0.200986345917351 3827 5711223 A potent inhibitor of glutathione S-transferases. SGTC_3293 9120939 62.045 µM -0.838678186192962 0.187448228604159 no 2749 0.200824961270543 3867 934087 SGTC_1484 3473-2379 286 µM -0.838957886672214 0.187368428855689 no 2750 0.200746471136935 3991 671917 SGTC_2026 5148700 152 µM -0.839210799669143 0.187296289773949 no 2751 0.200675514017536 3870 79838 SGTC_1731 st035964 63 µM -0.840124635437527 0.187035776988464 no 2752 0.200419254315995 3884 6739575 SGTC_2804 7954240 19.48 µM -0.84057699395819 0.186906903345199 no 2753 0.200292475777724 3932 828705 SGTC_1926 methyl fluorone black 53.6 µM -0.840858023079092 0.186826867876798 no 2754 0.200213738493198 3678 72721 Reacts with homocysteine. SGTC_2942 9052777 62.25 µM -0.842705613877677 0.186301212969382 no 2755 0.199696553356363 3964 6469503 SGTC_2713 st079149 53.4 µM -0.843091880584009 0.186191432813776 no 2756 0.199588529683544 3927 3103253 SGTC_2033 5192550 145 µM -0.844700887648478 0.185734571307365 no 2757 0.199138931877055 3884 182073 SGTC_1478 0453-0656 35.7 µM -0.845660373329972 0.185462466198193 no 2758 0.198871117612052 3911 5258496 SGTC_1561 5-methoxyflavone 52.9 µM -0.846747101442894 0.185154574805416 no 2759 0.198568049431061 3830 94525 SGTC_2984 9022109 38.96 µM -0.847215820579343 0.185021875531322 no 2760 0.198437418451341 3916 6459207 SGTC_1837 st055472 66.5 µM -0.84740947446583 0.184967067350642 no 2761 0.198383462684385 3998 676091 SGTC_2386 9075165 157.42 µM -0.848590487269404 0.184633033939979 no 2762 0.198054601041447 3862 16452277 SGTC_1049 3226-0134 66 µM -0.848730640638243 0.184593418378323 no 2763 0.198015596175553 3931 5702385 SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM -0.854181914154002 0.183056671793458 no 2764 0.196502101269042 3871 16623 A steroid. SGTC_2344 7990960 76.95 µM -0.855711283945354 0.182626971173116 no 2765 0.196078748574273 3890 140813 SGTC_131 0141-0277 33.849 µM -0.858731330097779 0.181780293245047 no 2766 0.19524438055601 3883 1547771 SGTC_1345 1488-0192 31.4 µM -0.859959691517863 0.181436622504854 no 2767 0.194905631197561 3916 658348 SGTC_1047 2043-3044 82 µM -0.860186309803306 0.181373263752272 no 2768 0.194843174984315 3910 669592 SGTC_1056 3448-1962 115 µM -0.861093700300417 0.181119711069516 no 2769 0.19459321927404 3909 715507 SGTC_3311 9131146 2.8755 µM -0.863648472256898 0.180407023013357 no 2770 0.193890513906447 3902 4900406 YPR165W RHO1 SGTC_2688 kanamycin b 96.69 µM -0.865241667803113 0.179963471614058 no 2771 0.193453079898114 4001 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis. SGTC_2180 6301957 200 µM -0.866854219080559 0.179515229489816 no 2772 0.193010945118136 3906 845462 SGTC_2315 7733312 200 µM -0.868622999899204 0.17902436790459 no 2773 0.192526685060006 3866 726316 SGTC_1688 st021091 57.6 µM -0.870518129262328 0.178499380934105 no 2774 0.192008658079098 3937 3656366 SGTC_2163 5671233 125 µM -0.875270361609838 0.177187192003443 no 2775 0.190713408325506 3924 701023 SGTC_1285 0929-0069 65.5 µM -0.879713615020275 0.175965844741499 no 2776 0.189507235924266 3964 1206237 SGTC_1908 st060353 56.5 µM -0.879790848204616 0.175944662376496 no 2777 0.189486311676098 3997 4227716 SGTC_392 N-ethylmaleimide 8.33 µM -0.879956638961238 0.175899197215997 no 2778 0.189441399943972 3883 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides. SGTC_109 0132-0036 33.701 µM -0.879991066031381 0.175889757138527 no 2779 0.189432074676448 3761 67274 A color developer. SGTC_237 nikkomycin 200 µM -0.881003903230338 0.175612175617759 no 2780 0.189157853683062 3935 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine. SGTC_2268 7933382 153.85 µM -0.881751695974662 0.175407411294747 no 2781 0.188955549199153 3959 935025 YOR257W CDC31 SGTC_3223 9129970 49.47 µM -0.883397228218496 0.17495735672811 no 2782 0.188510843921815 3968 17248386 SGTC_2487 5918373 44.05 µM -0.883833140580505 0.174838257169178 no 2783 0.188393146773379 3981 2876279 SGTC_599 1935-0052 86.5 µM -0.883915141876162 0.174815858605312 no 2784 0.188371011337323 3953 9557311 SGTC_3333 9141820 12.094 µM -0.884567541462495 0.174637721267081 no 2785 0.188194959703775 3943 1939433 SGTC_534 k292-0788 63.4 µM -0.887055566302667 0.173959425903989 no 2786 0.187524492495896 3941 4146317 SGTC_153 4077-0274 519.67 µM -0.888347317958678 0.173607924882769 no 2787 0.187176977097473 3955 3121976 SGTC_2952 9073731 13.78 µM -0.891403212567873 0.172778180164925 no 2788 0.186356447440299 4036 16457353 SGTC_1141 3253-0389 52.6 µM -0.893003206184006 0.172344755458952 no 2789 0.185927727845549 3921 5402031 SGTC_323 4013-0906 34.3 µM -0.894215700323741 0.172016763473755 no 2790 0.185603246737249 3968 2910086 SGTC_705 1124-0212 310 µM -0.895301945691739 0.171723261697996 no 2791 0.185312850247954 3903 9554485 SGTC_1525 8-methoxypsoralen 92.5 µM -0.895383560372794 0.17170122246803 no 2792 0.185291042805583 4031 4114 Related to psoralen; DNA damaging agent. SGTC_2068 5226020 147 µM -0.895698263243084 0.171616257016107 no 2793 0.185206969119603 4008 1810509 SGTC_1424 4048-1941 275 µM -0.899706432432196 0.170536456932969 no 2794 0.184138249665469 4038 X1424 SGTC_2257 7960413 200 µM -0.900020697648219 0.170451978247455 no 2795 0.184054618059156 3962 2974689 YIL048W NEO1 SGTC_1372 2752-0194 270 µM -0.900706145064958 0.170267813823626 no 2796 0.183872290270086 3934 823334 SGTC_39 0986-0283 58.349 µM -0.901134182959608 0.170152874276284 no 2797 0.183758490030734 4068 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2 SGTC_523 1934-0222 13.7 µM -0.901299504934758 0.170108494246838 no 2798 0.183714548473617 3948 1361595 SGTC_510 ag-490 170 µM -0.902437419300842 0.169803226920308 no 2799 0.183412275511381 4089 5328779 SGTC_812 4251-0442 148 µM -0.903877043027625 0.169417523960969 no 2800 0.183030301712721 3979 5723007 SGTC_2562 3',7'-dimethoxyflavone 64.92 µM -0.90487814166677 0.169149642031472 no 2801 0.182764974093994 4040 688664 SGTC_1055 3448-0672 86 µM -0.907099243728542 0.168556273600548 no 2802 0.182177158989549 4020 748378 SGTC_2719 novobiocin 32.65 µM -0.907573141311862 0.168429845067556 no 2803 0.182051895026972 3972 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication. SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM -0.907863853223271 0.168352317819552 no 2804 0.181975078653577 4007 368090 SGTC_219 mitoxanthrone 164.414 µM -0.908474087567087 0.168189654778859 no 2805 0.181813899084673 3946 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA.  YMR168C CEP3 SGTC_1613 st002381 52.1 µM -0.909258262081533 0.167980775043897 no 2806 0.181606908317135 3972 551167 SGTC_3317 9138495 8.753 µM -0.910852122885456 0.167556734834678 no 2807 0.181186647398832 3910 17020139 SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM -0.911854550001944 0.167290396685791 no 2808 0.180922644927935 4040 5393153 SGTC_2892 9047358 58.44 µM -0.912213245670714 0.16719515998079 no 2809 0.180828236262844 3980 6466771 SGTC_111 0083-0039 52.457 µM -0.913207092868409 0.166931467841611 no 2810 0.180566817127043 3879 759313 SGTC_1570 verbenone 133 µM -0.914294684387622 0.166643210583422 no 2811 0.180281011478164 4020 29025 A natural terpanoid with antifungal properties. SGTC_405 ebelactone b 50 µM -0.914380878763272 0.166620379213823 no 2812 0.180258372805919 3956 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).  SGTC_3305 9127027 53.8275 µM -0.914464324016256 0.166598277961691 no 2813 0.180236457881529 3914 41905295 SGTC_952 1185-0122 232 µM -0.915298898442935 0.166377337257216 no 2814 0.180017368625829 3928 678600 SGTC_10 0279-0212 42.575 µM -0.915634517031462 0.166288540778857 no 2815 0.179929310494335 3953 39851 YBR002C RER2 SGTC_1686 st019653 115.5 µM -0.91751107526932 0.165792613433546 no 2816 0.179437446004462 3939 97252 SGTC_1550 gossypolone 36.6 µM -0.920992022157091 0.164875220877569 no 2817 0.178527296102304 4002 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_1258 0671-0043 57.1 µM -0.921172928627391 0.164827633589744 no 2818 0.178480074797563 4024 4298767 SGTC_1429 4049-0205 9.46 µM -0.921916090498479 0.164632238862166 no 2819 0.178286172734067 4017 22774478 SGTC_307 1501-1223 22.3 µM -0.921970218031547 0.164618013327464 no 2820 0.178272055238304 4024 2830329 SGTC_209 4077-0173 175.592 µM -0.928115952018861 0.163008001486945 no 2821 0.17667371288077 3978 15993494 SGTC_2237 6667747 47.222 µM -0.932586389757031 0.161843323794318 no 2822 0.175516781618555 4011 729940 YDL015C TSC13 SGTC_2702 st077768 96.8 µM -0.932940118317322 0.161751399380323 no 2823 0.175425443549965 4010 6484119 SGTC_1059 3448-6867 171 µM -0.937419002052414 0.160590403220452 no 2824 0.174271535129995 3926 3934407 SGTC_2849 9019321 12.99 µM -0.937875445419737 0.160472392395669 no 2825 0.174154211645839 4036 16489627 SGTC_2565 isoliquiritigenin 100 µM -0.93818265824506 0.160392996183431 no 2826 0.174075274417015 4115 638278 Binds to benzodiazepine receptor 65X better than valium. SGTC_2465 5809242 33.21 µM -0.940329360633109 0.159838917997138 no 2827 0.173524321867049 4044 2731748 SGTC_277 nystatin 15.5 µM -0.940463203722962 0.15980441372004 no 2828 0.173490007743815 4000 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_1782 st039423 80.636 µM -0.941002574562536 0.159665415206018 no 2829 0.173351769910796 4049 2068169 SGTC_2532 xanthone 78.9 µM -0.943979635698007 0.15889963583099 no 2830 0.172590027404255 4041 7020 An insecticide. SGTC_3142 9086498 49.47 µM -0.944758290754957 0.158699742790624 no 2831 0.172391145094772 3952 25236367 SGTC_2232 chlorophetanol 41.5365 µM -0.945483372159133 0.15851375125625 no 2832 0.172206077950433 4092 15907 An antifungal of unknown mechanism. YFR051C RET2 SGTC_2238 6671620 73.2395 µM -0.951984055515369 0.156852641867586 no 2833 0.170552534114471 3958 729941 SGTC_1738 st035555 74 µM -0.952881116892756 0.156624319797835 no 2834 0.170325154294955 4104 5331140 SGTC_1701 st028638 40.4 µM -0.953139295303297 0.156558648216405 no 2835 0.170259749334748 4034 3490878 SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM -0.953860587306245 0.156375272778719 no 2836 0.170077107974801 4053 2374 Ca(2+)-ATPase inhibitor. SGTC_2270 7924575 90.91 µM -0.955834545404971 0.155874153240472 no 2837 0.169577916116134 4049 1262135 SGTC_1464 k208-0027 110 µM -0.958380386520867 0.155229417319346 no 2838 0.168935490867661 4030 X1464 SGTC_625 k213-0058 121 µM -0.960795903522798 0.154619315800289 no 2839 0.168327399366387 4106 3655420 SGTC_3047 9092122 49.47 µM -0.960843887073444 0.154607212383227 no 2840 0.168315334081777 4013 17173831 SGTC_601 0986-0029 62.9 µM -0.961115400406627 0.154538737394198 no 2841 0.168247073547112 3999 24747981 SGTC_135 0933-0004 26.348 µM -0.961514449446257 0.154438134602199 no 2842 0.168146781882242 4031 21230617 YGL099W LSG1 SGTC_3285 9112818 20.8695 µM -0.962729906275624 0.154131977062628 no 2843 0.167841542235224 4026 17017947 YPR165W RHO1 SGTC_2606 farnesol 9.78 µM -0.963119093165544 0.154034030934197 no 2844 0.167743880547969 4102 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_1929 genistein trimethyl ether 50.5 µM -0.963591675447264 0.153915152175855 no 2845 0.16762534101211 4033 136420 SGTC_821 1114-0266 29.2 µM -0.963922976015221 0.153831849248556 no 2846 0.167542271861679 4073 3123235 SGTC_727 3032-0951 202 µM -0.964081412153003 0.153792022274971 no 2847 0.167502555511448 4064 3652836 SGTC_2157 5649910 96.377 µM -0.964181450830735 0.153766878511504 no 2848 0.167477481205693 4041 2858091 SGTC_1838 st055369 84.5 µM -0.96441006039026 0.153709429903388 no 2849 0.167420190186251 4047 676036 SGTC_139 0099-0334 718.624 µM -0.966697125637467 0.153135482374756 no 2850 0.16684773222376 4092 97690 SGTC_2334 9017922 200 µM -0.969117120827559 0.152529724140977 no 2851 0.166243378184839 4135 3163164 SGTC_1608 st001473 40.5 µM -0.970993959784237 0.152061021619021 no 2852 0.165775643221826 4030 7292267 SGTC_2787 5284540 71.43 µM -0.971110869346967 0.152031857504354 no 2853 0.165746535871273 4114 736958 SGTC_3264 9137442 49.47 µM -0.973786664753969 0.151365372487755 no 2854 0.165081237837159 4067 17015726 SGTC_1485 3909-9022 254 µM -0.97382129406762 0.151356759801014 no 2855 0.165072639103784 4082 714516 SGTC_2546 rhodinyl acetate 100 µM -0.978314034843665 0.150242130123327 no 2856 0.163959515280898 4010 6708682 SGTC_1795 st049545 62.3 µM -0.978914932620553 0.150093465806452 no 2857 0.163811006640066 3985 5291882 SGTC_2437 5741531 144.16 µM -0.97904102134403 0.150062283445346 no 2858 0.163779855577972 4094 2262990 SGTC_98 0074-0023 107.663 µM -0.979179788050381 0.150027970749358 no 2859 0.163745576780073 4087 3563821 SGTC_1810 st050138 53 µM -0.980233201148791 0.14976766500416 no 2860 0.163485509647851 4072 3444541 SGTC_767 0929-0023 86 µM -0.98034485225735 0.149740092903428 no 2861 0.16345796089996 4080 1204563 SGTC_2883 9059145 45.46 µM -0.98082256560203 0.149622160435862 no 2862 0.163340124158846 4046 16476510 SGTC_1545 lovastatin 49.4 µM -0.981681985876925 0.149410152559125 no 2863 0.163128271396889 4131 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12 SGTC_2493 resveratrol 26.09 µM -0.983311243312015 0.149008786473601 no 2864 0.162727139098999 3942 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase. SGTC_1354 1498-1681 81 µM -0.983394657439673 0.148988256879889 no 2865 0.162706619352925 4074 5754243 SGTC_3269 9137823 49.47 µM -0.984742556682462 0.148656778600656 no 2866 0.162375271580537 3966 17682936 SGTC_1206 3978-0017 132 µM -0.98552393998534 0.148464845049144 no 2867 0.162183389019862 4176 3873677 SGTC_2549 cedrol 20.94 µM -0.986051720964114 0.148335298416589 no 2868 0.162053866595424 4031 6708665 A sedative which affects the nervous system. SGTC_1846 st056244 14.8 µM -0.989433514882408 0.147507014025008 no 2869 0.161225541828313 4105 5393182 SGTC_282 k297-0036 65.7 µM -0.992635960730647 0.146725518126875 no 2870 0.160443696713671 4089 5061378 SGTC_1163 k060-0048 49.9 µM -0.994232597206423 0.146336929067893 no 2871 0.160054820869915 4075 6809982 SGTC_1687 st020778 55.3625 µM -0.99533203230038 0.14606975088135 no 2872 0.159787401709844 4105 4259299 SGTC_2507 purpurin 79.67 µM -0.998165815559924 0.145382613390944 no 2873 0.159099479891991 4094 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1 SGTC_3191 9110352 49.47 µM -1.00154883856529 0.144565147572973 no 2874 0.158280770573429 4031 17122424 SGTC_2287 7945887 168.79 µM -1.01131839043172 0.142221866793323 no 2875 0.155932033414356 4121 1245853 SGTC_222 nsc-310342 10.666 µM -1.0118982919268 0.142083586960055 no 2876 0.155793343029416 4103 432556 SGTC_2371 9071574 200 µM -1.01257511355062 0.141922311257979 no 2877 0.155631575928211 4112 45596039 SGTC_2932 9016711 44.54 µM -1.01329042429434 0.141751998985496 no 2878 0.155460730003534 4126 7117328 SGTC_1088 bifonazole 369 nM -1.01644160203518 0.141003366279074 no 2879 0.154709571628716 4057 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase. SGTC_1274 0865-0114 173 µM -1.0193119463874 0.140323789598211 no 2880 0.154027447123366 4105 870624 SGTC_2236 dapsone 200 µM -1.01969133080034 0.140234134047291 no 2881 0.153937437225129 4108 2955 A bacterial DFR inhibitor. An anti-cancer agent. SGTC_2752 diclazuril 33.15 µM -1.02012111281094 0.140132615625319 no 2882 0.153835512429404 4077 456389 An antifungal agent for coccidioides. YHR062C RPP1 SGTC_560 2332-1943 155 µM -1.02061782258608 0.140015350464256 no 2883 0.153717771058858 4065 21177716 SGTC_130 0136-0219 337.655 µM -1.02126099952113 0.139863605866798 no 2884 0.15356539939633 3958 234244 SGTC_2014 4013930 200 µM -1.02253295964727 0.139563841800253 no 2885 0.15326436060016 4053 64556 SGTC_350 k064-0020 19.8 µM -1.02443673047187 0.139115995205864 no 2886 0.152814520267805 4141 2790705 SGTC_2455 5377712 9.75 µM -1.02639695120601 0.138655892355324 no 2887 0.152352257268516 4117 2243908 SGTC_633 0437-0093 97.7 µM -1.0270938002322 0.138492578052083 no 2888 0.152188148863323 4053 2831118 SGTC_2677 mitomycin C 100 µM -1.03101364698922 0.137576361354741 no 2889 0.15126721008507 4149 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_1684 st024538 14.6195 µM -1.03317363707774 0.137073261859 no 2890 0.150761323882175 4089 6732859 SGTC_1370 2001-0092 44.6 µM -1.034199076408 0.136834859658875 no 2891 0.15052155292025 4188 790957 SGTC_682 0kpi-0099 17 µM -1.03459946297246 0.136741851622136 no 2892 0.150428002454226 4159 1714895 YML126C ERG13 SGTC_3192 9110362 49.47 µM -1.03540275549552 0.136555380668529 no 2893 0.150240429706878 4142 16649480 SGTC_573 3702-0553 84.7 µM -1.03727975745945 0.136120344149377 no 2894 0.14980274843285 4079 1222756 SGTC_3012 9080433 71.4286 µM -1.03810812675467 0.135928653353692 no 2895 0.149609859185951 4133 17688859 SGTC_3283 9109332 35.8195 µM -1.04129442770682 0.13519304296196 no 2896 0.148869461041218 3970 17027281 SGTC_1900 st060200 72.8 µM -1.044309937157 0.134499380803555 no 2897 0.148171008403403 4122 688945 SGTC_2777 climbazole 1.536 µM -1.04447766311897 0.134460870408833 no 2898 0.14813222417301 3995 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2 SGTC_877 0771-0151 33.1 µM -1.04714944411453 0.133848441963711 no 2899 0.147515329026419 4156 6166523 SGTC_104 0074-0074 590.992 µM -1.05013765403582 0.133165755814099 no 2900 0.146827414458332 3923 3943124 SGTC_1432 4049-0298 68.4 µM -1.05018248248813 0.133155532587113 no 2901 0.146817110929761 4163 741646 SGTC_2422 chlorphenesin carbamate 384.24 µM -1.0537692466151 0.132339313220006 no 2902 0.145994288323833 4132 2724 A muscle relaxant with antifungal properties. SGTC_3034 9090421 49.47 µM -1.05466341678516 0.132136370174519 no 2903 0.145789644394799 4039 17173761 SGTC_1196 1588-0294 184 µM -1.05499531964375 0.13206109532622 no 2904 0.14571373265851 4161 6144269 SGTC_1299 1079-1439 3.74 µM -1.05694900982394 0.131618601995416 no 2905 0.145267429636853 4112 323161 SGTC_760 0568-0725 82.9 µM -1.05792973314292 0.131396863127598 no 2906 0.145043739262264 4182 3916171 SGTC_2545 solidagenone 89.61 µM -1.05804489644926 0.131370841949716 no 2907 0.145017487212718 3986 6708572 An anti ulcer agent SGTC_1229 0139-0193 12.2 µM -1.05880040388591 0.13120022309158 no 2908 0.144845344847112 4237 3090752 SGTC_3173 9105693 49.47 µM -1.06006404619768 0.130915192570362 no 2909 0.144557731593383 4163 17096658 SGTC_125 0133-0007 11.75 µM -1.06014877362764 0.130896096545158 no 2910 0.144538460849897 4232 26541 SGTC_2995 9067767 71.4286 µM -1.06363463289505 0.130112115454677 no 2911 0.143747123477075 4168 11673567 SGTC_3306 9127676 59.7925 µM -1.06373911025313 0.130088668421067 no 2912 0.143723450907751 4153 41905287 SGTC_2668 2',4'-dihydroxychalcone 15.08 µM -1.06437834623882 0.129945273386703 no 2913 0.143578669558037 4197 5357218 A potent inhibitor of glutathione S-transferases. SGTC_851 0394-0702 453 µM -1.06526501463243 0.129746554895795 no 2914 0.14337800996078 4162 762646 SGTC_1061 3448-9325 110 µM -1.06771954062547 0.129197549060211 no 2915 0.142823520635484 4097 723482 SGTC_45 0kpi-0036 14.9 µM -1.06887508429287 0.128939645972411 no 2916 0.142562980187252 4197 2795021 SGTC_2867 9039098 71.43 µM -1.06957993084268 0.128782508351825 no 2917 0.142404216340505 4113 6463460 SGTC_228 caffeine 993.056 µM -1.07066313529006 0.128541279140888 no 2918 0.1421604621177 4174 2519 Caffeine is a phosphodiesterase inhibitor. SGTC_961 1252-1571 372 µM -1.07136099473967 0.128386032318963 no 2919 0.142003571984951 4188 6813498 SGTC_3237 9133362 49.47 µM -1.07230826552854 0.128175509429459 no 2920 0.141790797737743 4140 43845137 SGTC_574 1315-0397 40 µM -1.07271107125118 0.128086061967332 no 2921 0.141700385707059 4138 6794277 SGTC_750 4073-0104 132 µM -1.07362985203931 0.127882198809221 no 2922 0.141494306290225 3913 22330957 SGTC_2425 5628681 7.85 µM -1.07532507336194 0.127506647608652 no 2923 0.141114607165718 4238 5714958 SGTC_3355 9151058 44.0485 µM -1.07655059687248 0.127235629058511 no 2924 0.140840542591386 4165 17015728 SGTC_1778 st046819 58.9 µM -1.07765796419355 0.126991085065676 no 2925 0.140593212127284 4214 671715 SGTC_2882 9058044 58.44 µM -1.08443704413367 0.125501167389888 no 2926 0.13908553321003 4218 18076804 SGTC_3110 9122132 49.47 µM -1.08453217903568 0.12548034564805 no 2927 0.13906445364823 4278 918317 SGTC_967 1306-0166 352 µM -1.08510004255209 0.125356110097986 no 2928 0.138938674248857 4199 4437607 SGTC_2568 diosmetin 100 µM -1.09100718524917 0.124068853536429 no 2929 0.137634860469491 4241 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.  SGTC_3312 9133330 71.43 µM -1.09693809694311 0.122785751103844 no 2930 0.136334226740777 4233 17617324 SGTC_684 1140-0066 328 µM -1.09737186745268 0.122692275090704 no 2931 0.136239433078316 4233 6813534 SGTC_685 1278-0033 54.9 µM -1.09827508926212 0.122497794192245 no 2932 0.136042193043405 4264 3590572 SGTC_1156 4092-0367 4.88 µM -1.10381854268916 0.121308920539937 no 2933 0.134835929788688 4217 1357585 SGTC_3195 9113082 49.47 µM -1.10444877244257 0.121174274085814 no 2934 0.134699256907187 4189 17018038 SGTC_2216 7189485 200 µM -1.10488392883654 0.121081365764536 no 2935 0.134604943525198 4204 731273 SGTC_2611 pyromycin 23.93 µM -1.10612471541385 0.120816726097106 no 2936 0.134336271238471 4166 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release. SGTC_257 daunorubicin 18.5 µM -1.10739404404565 0.120546420389206 no 2937 0.13406179993267 4216 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_476 mead acid 10 µM -1.11119679605598 0.119739167725897 no 2938 0.133241825026078 4240 5312531 An omega 9 fatty acid. SGTC_2835 9006588 71.43 µM -1.1123586741323 0.119493284921763 no 2939 0.132991982800703 4262 2345538 SGTC_155 k072-0202 43.6 µM -1.11274487614569 0.119411633737333 no 2940 0.132909008052298 4184 5857737 SGTC_2544 sphondin 68.51 µM -1.11399182281688 0.119148271905247 no 2941 0.13264134735579 4202 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31 SGTC_526 4469-0568 170 µM -1.11534445647408 0.118863052344778 no 2942 0.132351420757186 4164 2901964 SGTC_2904 7225135 42.03 µM -1.11810831181109 0.118281759373302 no 2943 0.131760368472204 4308 4446116 SGTC_3290 9121031 71.43 µM -1.11857824779067 0.118183122889259 no 2944 0.131660053787191 4223 17014854 SGTC_1162 k048-0130 20.1 µM -1.11920742006124 0.118051154840226 no 2945 0.131525830332512 4163 6797406 SGTC_1165 k072-0275 30.3 µM -1.12163834995777 0.117542249968484 no 2946 0.131008119449446 4194 6153523 YGL055W OLE1 SGTC_273 hydroxyurea 18.1 mM -1.12186789500389 0.117494276062071 no 2947 0.130959306495707 4289 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12 SGTC_1276 0871-0068 94.2 µM -1.12322892947743 0.117210110616779 no 2948 0.130670139503234 4213 3414906 SGTC_3160 9100216 49.47 µM -1.12438522155596 0.116969075371707 no 2949 0.13042481937822 4183 17191039 SGTC_1494 4358-1428 177 µM -1.12767634458534 0.116284946689286 no 2950 0.129728315711749 4240 1564571 SGTC_178 4092-0806 87.505 µM -1.12806362328311 0.116204629810394 no 2951 0.129646525244355 4107 2169044 SGTC_40 0327-0103 19.753 µM -1.1288322504979 0.116045342517078 no 2952 0.129484302527551 4082 409036 SGTC_1322 1348-1070 12 µM -1.13376594893863 0.115026592066778 no 2953 0.128446368919047 4216 6758089 SGTC_2698 st077697 67.5 µM -1.13406696081894 0.114964643174344 no 2954 0.128383230595085 4194 3154499 SGTC_3272 9137413 49.47 µM -1.13413743451038 0.114950142965734 no 2955 0.12836845159827 4126 17614870 SGTC_94 0334-0113 514.748 µM -1.13537915391423 0.114694868200948 no 2956 0.12810824508273 4245 6795178 SGTC_2830 7992007 71.43 µM -1.13720133290153 0.114320992302943 no 2957 0.127727064947925 4114 1952075 SGTC_805 3852-0218 479 µM -1.13754568895702 0.114250434702196 no 2958 0.127655118045281 4193 6615355 SGTC_482 fipronil 114 µM -1.1387511184086 0.114003689845609 no 2959 0.12740348753964 4323 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels. SGTC_221 trifluoperazine 10.304 µM -1.13883044309423 0.113987465837669 no 2960 0.12738694080764 4200 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1 SGTC_2214 7179297 48.276 µM -1.1428028583357 0.113177104075664 no 2961 0.126560225894384 4285 769744 SGTC_2521 angolensin 13.4 µM -1.14867414219353 0.111986919059032 no 2962 0.125345186031125 4279 821428 A flavenoid. SGTC_274 sirtinol 40.1 µM -1.1515485110714 0.11140752153603 no 2963 0.124753324945627 4296 6836442 NAD-dependent acetyltransferase inhibitor. SGTC_1904 st060225 78 µM -1.15883503518731 0.109948370434833 no 2964 0.123261716813864 4195 66595 SGTC_396 dithiazanine 1.25 µM -1.16136492568087 0.109444972763633 no 2965 0.12274676317534 4236 10578 An antihelmenthic. SGTC_1947 st076332 61.6 µM -1.16273560311971 0.109172927729844 no 2966 0.122468395875739 4132 24208416 SGTC_1517 deoxycholic acid methyl ester 49.2 µM -1.16273856963602 0.109172339478316 no 2967 0.122467793894496 4245 229346 A bile salt which induces apoptosis. SGTC_2853 9015042 58.44 µM -1.16355277025442 0.109010971959994 no 2968 0.122302650468073 4182 6457456 SGTC_2755 lomerizine 42.69 µM -1.16468302607752 0.108787249317595 no 2969 0.12207366111176 4216 3949 A calcium channel blocker. SGTC_657 3534-0529 86.7 µM -1.16828684733276 0.10807611459366 no 2970 0.12134553946642 4299 1049549 SGTC_3102 9121669 49.47 µM -1.17359320694962 0.107035123007518 no 2971 0.120279001713147 4301 41905072 SGTC_2666 tannic acid 100 µM -1.17656855825322 0.106454598370869 no 2972 0.119683876715721 4259 16134267 A thiamine antagonist. SGTC_995 3931-2021 34.6 µM -1.17677650983735 0.106414109829215 no 2973 0.119642360353278 4263 730143 SGTC_2289 7946404 165.07 µM -1.17691925323577 0.106386323873411 no 2974 0.119613868317532 4259 1246120 YPR165W RHO1 SGTC_1466 k213-0079 57.5 µM -1.17711074725961 0.106349056511777 no 2975 0.119575653019289 4202 3657981 SGTC_1597 7-benzyloxygramine 47.5 µM -1.17802253289562 0.106171739839374 no 2976 0.119393811633855 4183 260807 SGTC_444 curcumin 90.4 µM -1.17945498119554 0.105893600393756 no 2977 0.119108526449007 4197 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. SGTC_1650 st011916 45.8 µM -1.18171889139982 0.105455089904764 no 2978 0.118658629942881 4199 242528 SGTC_954 1189-0853 2.85 µM -1.18458529026029 0.104901765937538 no 2979 0.11809072790399 4199 2828194 SGTC_2782 7736369 71.43 µM -1.18632470678944 0.104567018864178 no 2980 0.117747046612732 4283 2950836 YOL077C BRX1 SGTC_2771 fluoxetine 41.05 µM -1.18748069239792 0.10434498028722 no 2981 0.117519033969509 4300 3386 A selective serotonin reuptake inhibitor. SGTC_2117 5521686 200 µM -1.18824887305396 0.104197619323883 no 2982 0.117367686995705 4239 803312 SGTC_1749 st037932 54.2 µM -1.18831622342518 0.104184706622656 no 2983 0.117354424208299 4306 594497 SGTC_2138 5575593 77.673 µM -1.19290293255671 0.103308050668434 no 2984 0.116453695303 4288 762213 SGTC_3238 9133470 49.47 µM -1.19461005683998 0.102983140050819 no 2985 0.11611970907378 4279 3534688 SGTC_3053 9095903 49.47 µM -1.19695461238723 0.102538120251342 no 2986 0.115662123002851 4403 17174018 SGTC_351 caspofungin 25 nM -1.19723933622407 0.102484172200314 no 2987 0.115606640894194 4274 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1 SGTC_1205 4161-2785 76 µM -1.20093152868772 0.101786462128071 no 2988 0.114888881431683 4326 3498106 SGTC_1856 st057054 55.7 µM -1.20250773426362 0.101489663561871 no 2989 0.114583435683269 4294 1266018 SGTC_308 4092-1169 104 µM -1.20309768876631 0.101378737751461 no 2990 0.114469259843779 4231 2268590 YDL196W YDL196W SGTC_2053 5265679 138 µM -1.20342788732014 0.101316690947253 no 2991 0.114405390790038 4194 764595 SGTC_2912 7964298 10.93 µM -1.20435668524092 0.101142311167597 no 2992 0.114225872992034 4291 2975850 SGTC_826 1683-5028 118 µM -1.20549760606711 0.100928405269726 no 2993 0.114005630817173 4325 722377 SGTC_1625 st003711 30.1 µM -1.20624372389884 0.100788697617578 no 2994 0.113861764720017 4356 24207034 YER133W GLC7 SGTC_1529 apigenin 74 µM -1.20946562827449 0.100187027823123 no 2995 0.113242004233865 4307 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_1289 0976-0073 69.1 µM -1.20947990863991 0.100184366906393 no 2996 0.113239262652692 4358 3391136 SGTC_1320 1313-0481 95.3 µM -1.20973302421408 0.100137211445609 no 2997 0.113190676733249 4262 6813365 YLR208W SEC13 SGTC_1697 st025554 27.742 µM -1.21097006957191 0.0999069828582369 no 2998 0.112953437963273 4289 1269519 SGTC_479 n-linoleoylglycine 10 µM -1.21751609560837 0.0986951243945909 no 2999 0.111703958124782 4344 6433346 An anti-infammatory. SGTC_414 piperonyl butoxide 100 µM -1.21777257651834 0.0986478623655914 no 3000 0.111655204144529 4298 5794 A potent inhibitor of cytochrome P450. SGTC_1215 3852-0577 11.2 µM -1.22093448150019 0.0980665749622141 no 3001 0.111055413827488 4341 2884876 SGTC_1790 st045711 43.5 µM -1.221669134769 0.0979318756866623 no 3002 0.11091638642285 4304 585119 SGTC_1809 st050081 57.6 µM -1.22213264457506 0.0978469605775321 no 3003 0.110828734975817 4375 5036894 SGTC_1518 st038567 90.8 µM -1.22262257636801 0.0977572636384067 no 3004 0.110736140994422 4239 77966 SGTC_787 4152-0075 138 µM -1.22303368738537 0.0976820437685331 no 3005 0.110658486421178 4316 9566539 SGTC_1743 st037606 46.3785 µM -1.22356951736222 0.097584068119905 no 3006 0.110557332333896 4272 590142 YLR208W | YDL195W SEC13 | SEC31 SGTC_1873 rapamycin 2 nM -1.22363749116035 0.0975716443729256 no 3007 0.110544504965959 4255 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1 SGTC_375 3970-0961 9.27 µM -1.22442994642732 0.0974268908517067 no 3008 0.110395039067007 4243 2898222 SGTC_3052 9092717 49.47 µM -1.22531404417207 0.0972655834682574 no 3009 0.110228459444535 4309 25237534 SGTC_2968 9090663 33.37 µM -1.2269005851512 0.0969766038464296 no 3010 0.109929979307912 4256 25236811 SGTC_2796 7949634 45.45 µM -1.22823245489248 0.0967344982224299 no 3011 0.109679859314037 4283 2971588 SGTC_1302 1159-0335 255 µM -1.2301238825204 0.0963914401027739 no 3012 0.10932535899734 4330 649284 SGTC_741 4582-0002 126 µM -1.23043430607552 0.0963352224709089 no 3013 0.109267256664471 4336 2912688 SGTC_2306 7482397 179.52 µM -1.23090637469107 0.0962497771471561 no 3014 0.109178941566745 4328 891448 SGTC_2366 9070441 60.58 µM -1.23231924121554 0.0959943784738216 no 3015 0.108914927503621 4288 6837235 SGTC_1184 1269-1718 139 µM -1.23587717989685 0.0953534313141909 no 3016 0.108252110340527 4365 5403821 SGTC_2319 6033012 152.6 µM -1.2370513760818 0.0951425979639879 no 3017 0.108034004895995 4260 847246 SGTC_3210 9128157 49.47 µM -1.23863397530707 0.0948589770763759 no 3018 0.107740539969546 4301 17590849 SGTC_729 4092-0585 94.1 µM -1.23874213988286 0.094839615446395 no 3019 0.107720503755625 4335 2169061 SGTC_2705 st078069 42.8 µM -1.23996673970553 0.0946206132179392 no 3020 0.107493848269855 4353 1530061 SGTC_1985 st071382 65.5 µM -1.24507771753281 0.0937106116131144 no 3021 0.106551591954107 4320 6123237 SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM -1.24702698011461 0.0933652559014213 no 3022 0.106193802483267 4320 5379071 SGTC_3172 9105863 49.47 µM -1.25136056611895 0.0926008340433222 no 3023 0.105401478784606 4406 2348785 SGTC_989 1501-0895 10.3 µM -1.25460714211849 0.0920311955836479 no 3024 0.104810704732873 4288 2830112 SGTC_1249 0481-0015 10.2 µM -1.25602093666734 0.0917839462765408 no 3025 0.104554189670892 4250 4227577 SGTC_2250 alverine citrate 130 µM -1.25643937577153 0.091710862644925 no 3026 0.104478356505286 4211 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1 SGTC_3221 9128209 49.47 µM -1.25752950151558 0.0915206662204419 no 3027 0.104280981621041 4362 16460723 SGTC_1569 carminic acid 40.6 µM -1.25941843489839 0.0911917926003359 no 3028 0.103939617131647 4409 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_1242 0402-0103 60.1 µM -1.26049536842464 0.0910046852571886 no 3029 0.103745358824766 4259 432868 SGTC_1057 3448-5381 134 µM -1.26158582337948 0.0908155190009554 no 3030 0.103548930013569 4318 5497911 SGTC_591 4299-0174 154 µM -1.27140914625343 0.0891245579698834 no 3031 0.101791565240141 4369 5509088 SGTC_2597 laccaic acid a 100 µM -1.27183383788527 0.0890519846674304 no 3032 0.10171608173214 4338 5491415 A textile dye. SGTC_930 2810-3379 265 µM -1.27284079447335 0.0888800869881302 no 3033 0.101537270952183 4358 1015764 SGTC_1363 1636-0063 10.4 µM -1.27488370317047 0.088532101022435 no 3034 0.101175204065781 4354 6072185 SGTC_3239 9133757 49.47 µM -1.27717420060524 0.0881431492590012 no 3035 0.100770376604629 4389 17036923 SGTC_5 0352-0601 109.883 µM -1.27837376850397 0.0879399583367578 no 3036 0.100558834297231 4249 762456 SGTC_907 3448-6986 75.5 µM -1.27911202873255 0.0878150805867399 no 3037 0.100428804171949 4377 590582 SGTC_2758 dehydroepiandrosterone 69.35 µM -1.27952216627517 0.0877457624252925 no 3038 0.100356619485346 4352 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem] SGTC_2265 7929201 200 µM -1.27964085277931 0.087725710600472 no 3039 0.100335737587635 4330 1265108 SGTC_1003 4049-0218 100 µM -1.28162485050634 0.0873910245425473 no 3040 0.0999871392154117 4361 295161 SGTC_1395 3486-0190 4.35 µM -1.2829963125054 0.0871602265927887 no 3041 0.0997466839883904 4326 6748079 SGTC_1300 1094-0077 113 µM -1.28606307020176 0.0866457813589154 no 3042 0.099210525601655 4312 5532636 SGTC_1313 1220-0047 237 µM -1.2870414720981 0.0864821339645915 no 3043 0.0990399167289869 4342 3528706 SGTC_320 4092-0846 5.34 µM -1.29356885762528 0.0853962729370862 no 3044 0.0979071926485218 4314 1359356 SGTC_374 0880-0231 82.3 µM -1.29509310225036 0.0851441848691761 no 3045 0.0976440570645206 4235 6833587 SGTC_278 4092-0821 23.9 µM -1.30062731847691 0.0842335925446768 no 3046 0.0966930257315625 4362 877900 SGTC_1852 st056254 31.4 µM -1.30174684116281 0.0840502799629304 no 3047 0.0965014706700458 4323 442583 SGTC_3040 9091894 49.47 µM -1.30389979128883 0.0836985942869968 no 3048 0.0961338757257747 4227 25236966 SGTC_2416 tofa 880 nM -1.30554908259936 0.0834299302587641 no 3049 0.0958529726780038 4328 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_1952 st077036 64.1 µM -1.31180178135388 0.0824172715933789 no 3050 0.0947935118712654 4390 2937007 SGTC_1013 4112-3890 241 µM -1.31392491925797 0.0820755309672286 no 3051 0.0944357359288881 4317 705171 SGTC_2799 7812892 81.82 µM -1.31406646166143 0.0820527862924416 no 3052 0.0944119196704905 4401 20205235 SGTC_1588 farnesol 29.9 µM -1.31434739431489 0.0820076568424038 no 3053 0.0943646623998716 4390 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_1042 0350-0096 82 µM -1.31698708536704 0.0815845258991613 no 3054 0.0939214767751926 4374 3122515 SGTC_781 4335-2806 94.4 µM -1.31719260869252 0.0815516506102135 no 3055 0.0938870354151495 4432 845254 SGTC_2211 7117706 200 µM -1.31792141471122 0.0814351521038314 no 3056 0.0937649780857062 4304 822771 SGTC_1410 3909-8106 77.9 µM -1.32186239123376 0.0808073666724435 no 3057 0.0931069889308415 4419 1039210 SGTC_2503 beta-caryophyllene alcohol 24.72 µM -1.32267420265502 0.0806785026977124 no 3058 0.0929718730433372 4394 61125 An anti-inflammatory. SGTC_2358 9037157 4 µM -1.32424496318378 0.0804296066572922 no 3059 0.092710851197455 4386 2388925 SGTC_3326 9140064 16.379 µM -1.33126271378249 0.0793246855404442 no 3060 0.091551291173239 4337 1868434 SGTC_737 1950-0117 57.9 µM -1.33175540392045 0.0792475469548649 no 3061 0.0914702883717192 4373 5393513 SGTC_1865 st057639 52.2 µM -1.33956303702914 0.0780327049201243 no 3062 0.0901937238013802 4383 688818 SGTC_2762 leflunomide 42.06 µM -1.34016710124984 0.0779393066399296 no 3063 0.0900955123525837 4371 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1 SGTC_3147 9097027 49.47 µM -1.34131959338519 0.0777613477128632 no 3064 0.0899083554904615 4396 25236841 SGTC_1489 4065-0444 182 µM -1.34373923729924 0.0773887287475985 no 3065 0.0895163622043527 4412 2877968 SGTC_3266 9136860 49.47 µM -1.34509640879683 0.0771803223255043 no 3066 0.0892970514005623 4172 4871271 YPR165W RHO1 SGTC_2517 totarol 10 µM -1.3457719418321 0.077076746972133 no 3067 0.0891880384177758 4389 460178 An antibacterial membrane disruptor. YGL001C ERG26 SGTC_823 0417-1665 178 µM -1.34674682469773 0.076927460398324 no 3068 0.0890308929910606 4404 3429856 SGTC_585 0kpi-0023 191 µM -1.35036962796362 0.0763746159000067 no 3069 0.0884487240644401 4333 64601 SGTC_2155 5570423 76 µM -1.35105939873706 0.0762696994114529 no 3070 0.0883382030183865 4363 797402 SGTC_2539 epi(13)torulosol 80 µM -1.35254284855599 0.0760444332728727 no 3071 0.0881008605727044 4382 6708597 SGTC_2649 anisomycin 9.56 µM -1.35498054971249 0.0756753618948534 no 3072 0.0877118770326832 4440 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_1362 1611-0397 101 µM -1.3619229773945 0.0746317454370651 no 3073 0.0866110969538901 4389 27816 SGTC_1519 esterone 74 µM -1.36696225691757 0.0738811248178254 no 3074 0.0858185680713931 4384 698 A steroid. SGTC_438 sphingosine 6.67 µM -1.36731501560618 0.0738287968664598 no 3075 0.0857632935721445 4339 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes. SGTC_255 tunicamycin 200.472 nM -1.36766805108101 0.0737764562203895 no 3076 0.0857080023883038 4331 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_2528 xanthyletin 44.79 µM -1.36772911782491 0.0737674054109704 no 3077 0.0856984410358586 4437 65188 An natural product with antifungal activity of unknown mechanism. SGTC_2721 ifenprodil 61.44 µM -1.3756056191007 0.0726071148243791 no 3078 0.0844718830449196 4410 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor. SGTC_1440 4100-1550 40 µM -1.37596143513903 0.0725550313009587 no 3079 0.0844167866015295 4431 742806 SGTC_2249 haloperidol 116.36 µM -1.37646541702946 0.0724813085847358 no 3080 0.0843387935207407 4373 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_678 1218-2179 85.9 µM -1.376814720726 0.072430245949021 no 3081 0.0842847692034065 4460 6820081 YOR116C RPO31 SGTC_3035 9091303 49.47 µM -1.38452417169858 0.0713102508681083 no 3082 0.0830990059932205 4500 25237002 SGTC_300 r073-0011 5.04 µM -1.38529010393849 0.0711997096347058 no 3083 0.082981889242668 4432 2735780 SGTC_1263 0774-1208 64.8 µM -1.38566278865954 0.0711459704593204 no 3084 0.0829249478926625 4431 906585 SGTC_2896 9052656 71.43 µM -1.39104497451797 0.0703733560272008 no 3085 0.0821058945607351 4148 6469436 SGTC_3092 9117248 49.47 µM -1.39749372515563 0.0694561502432895 no 3086 0.0811325761412871 4556 17141857 SGTC_809 3998-0021 90 µM -1.39874807703362 0.0692788181139388 no 3087 0.0809442708023475 4377 715485 SGTC_1957 st077035 62.4 µM -1.40023085547318 0.069069642603287 no 3088 0.0807220994142781 4448 705593 SGTC_981 1488-1094 54.9 µM -1.40068024778418 0.0690063430483503 no 3089 0.0806548559486099 4407 3449522 SGTC_1515 3460-0031 42.1 µM -1.4048903740968 0.0684154916508659 no 3090 0.0800269396993685 4418 2876596 SGTC_1224 0823-0416 294 µM -1.40664934103886 0.0681697964031835 no 3091 0.0797656971986774 4460 3598164 SGTC_1369 1866-0067 208 µM -1.40711046338897 0.068105498922856 no 3092 0.0796973179528381 4455 3531355 SGTC_1408 3909-7976 48.8 µM -1.40789674114974 0.0679959707581599 no 3093 0.0795808241109746 4485 24152374 SGTC_3074 9116018 49.47 µM -1.40887645616197 0.0678596872306247 no 3094 0.0794358512113194 4495 17027303 SGTC_831 k061-1017 217 µM -1.41526420701347 0.0669762831708893 no 3095 0.0784955226458271 4476 1240153 SGTC_1724 st037281 8.293 µM -1.41656862497815 0.0667969852251512 no 3096 0.0783045435252578 4398 574124 YDL195W SEC31 SGTC_1325 1431-0015 227 µM -1.41734651133265 0.0666902382578889 no 3097 0.07819082144757 4461 1103340 SGTC_1723 st034307 2.5525 µM -1.4175969467571 0.0666558998770324 no 3098 0.078154236037873 4446 867466 SGTC_309 k408-0051 1.48 µM -1.41885305387879 0.0664838755107156 no 3099 0.077970930734187 4372 3640463 SGTC_1950 st077106 7.18 µM -1.41924275492759 0.0664305757125531 no 3100 0.0779141275207138 4364 13831864 SGTC_1131 3454-3128 32.3 µM -1.42169204869294 0.0660963404473565 no 3101 0.0775578347066017 4448 710982 SGTC_2675 theaflavin digallate 100 µM -1.42670373978482 0.0654164971818482 no 3102 0.0768326536169949 4384 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative. SGTC_2079 5212404 121 µM -1.42676889499249 0.0654076946316581 no 3103 0.0768232598588535 4404 758462 SGTC_2868 9035608 32.47 µM -1.43185411468192 0.0647235049379003 no 3104 0.0760927882153026 4438 6462614 SGTC_2098 5376439 882.5 nM -1.4372804445938 0.0639995639465536 no 3105 0.0753191615456195 4496 2844116 SGTC_486 niguldipine 82 µM -1.43758713009311 0.0639588369709372 no 3106 0.0752756173543029 4531 1236 A calcium channel blocker. SGTC_2383 9036125 200 µM -1.43977500062222 0.0636688783651468 no 3107 0.0749655330949592 4408 79580 SGTC_1140 3229-1848 2.98 µM -1.44490543478871 0.0629929530583528 no 3108 0.0742422247817345 4448 2849525 SGTC_2136 5328288 199.296 µM -1.44921988178693 0.0624288706343594 no 3109 0.0736380934662233 4434 262395 SGTC_2006 4011487 200 µM -1.44996369811758 0.0623320213545632 no 3110 0.0735343213348943 4432 45595294 SGTC_2226 7298446 200 µM -1.45100125878871 0.0621971205957138 no 3111 0.0733897548456704 4473 3283010 SGTC_2073 5212005 126 µM -1.45174933581637 0.0620999990712331 no 3112 0.0732856579331278 4363 691789 SGTC_887 0885-0007 9.62 µM -1.4531299418462 0.0619210681477707 no 3113 0.073093839562786 4492 5719458 SGTC_3049 9092223 49.47 µM -1.4543716578405 0.0617604817273301 no 3114 0.0729216466537298 4457 8623917 SGTC_31 0508-1974 57.237 µM -1.4552135794659 0.0616517842773983 no 3115 0.0728050713268688 4418 6810525 SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM -1.45568233208923 0.0615913300924683 no 3116 0.0727402281121587 4469 688798 SGTC_2801 7907800 81.82 µM -1.45667904022386 0.0614629402991081 no 3117 0.0726024990550025 4451 6620925 SGTC_441 propafenone 146 µM -1.46303382484461 0.0606492652717815 no 3118 0.0717290618307378 4457 4932 Slows the influx of sodium ions into the cardiac muscle. SGTC_2281 7943571 200 µM -1.46423823713709 0.0604960048373808 no 3119 0.0715644330174802 4560 1244024 SGTC_47 0149-0135 24.25 µM -1.46511783564117 0.0603842682648118 no 3120 0.0714443856748887 4488 5239155 SGTC_2087 5276107 200 µM -1.46702686480808 0.0601423174200753 no 3121 0.0711843737030424 4444 144405 SGTC_782 0083-0095 30.5 µM -1.46924436872303 0.0598622240210653 no 3122 0.0708832599565815 4442 3591729 An indicator and reagent. SGTC_2482 5981709 142.65 µM -1.47073537113705 0.0596744703778585 no 3123 0.0706813482714869 4413 877755 SGTC_1280 0880-0253 10.1 µM -1.48218711796158 0.0582477582578579 no 3124 0.0691452566377029 4463 6836607 SGTC_976 1348-1067 47.6 µM -1.48547837890447 0.0578427138820836 no 3125 0.06870857333168 4502 5310671 YGL099W LSG1 SGTC_2251 lansoprazole 556 µM -1.48897521944763 0.0574147989918016 no 3126 0.0682469471440108 4456 3883 Gastric proton pump inhibitor. YBR192W RIM2 SGTC_1344 1488-0097 29.1 µM -1.49178424472882 0.0570728605256475 no 3127 0.067877857769326 4518 747966 SGTC_1307 1187-1599 12.2 µM -1.49958519188245 0.0561316674293545 no 3128 0.0668609429349902 4502 1538471 SGTC_1032 k061-1018 98.7 µM -1.50505462702218 0.0554791042945911 no 3129 0.066155016449893 4541 4005393 SGTC_419 nsc-638432 893 µM -1.50508413053884 0.0554756005154843 no 3130 0.066151224220735 4465 368090 SGTC_431 k089-0097 107 µM -1.50530944451541 0.0554488484358011 no 3131 0.0661222690827606 4227 5499420 SGTC_960 1222-0186 7.7 µM -1.5058353490695 0.055386446133893 no 3132 0.0660547232007429 4481 3126296 SGTC_50 0929-0078 56.389 µM -1.50975425631667 0.0549231846441459 no 3133 0.065553070610594 4349 1377751 SGTC_291 SEC14.278 35.5 µM -1.51119177605564 0.0547540223528165 no 3134 0.0653697985507142 4512 1068044 SGTC_1323 1348-1351 11.2 µM -1.51762895357184 0.0540015641100546 no 3135 0.0645539817893497 4498 6989654 SGTC_2724 maprotiline 69.64 µM -1.52207194091201 0.0534870036710789 no 3136 0.0639955278702472 4445 4011 A tricyclic antidepressant. SGTC_505 gw-5074 63.9 µM -1.53497841689811 0.05201426447469 no 3137 0.0623945648581935 4525 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases. SGTC_204 PMA1.184 62.41 µM -1.53620364752565 0.0518761461474136 no 3138 0.0622442208561618 4482 2252213 YGL008C PMA1 SGTC_179 1273-0063 6.77 µM -1.53623107656319 0.0518730574536936 no 3139 0.0622408583660915 4485 3108139 SGTC_894 0960-0238 55.9 µM -1.54539850840212 0.0508489032864494 no 3140 0.0611249504456008 4516 6741907 YDL195W SEC31 SGTC_1458 k015-0034 6.33 µM -1.54625097313836 0.0507544927392462 no 3141 0.0610219836784168 4549 3598957 SGTC_1021 4476-0760 85.3 µM -1.54748514600592 0.0506180553757495 no 3142 0.0608731517845185 4529 746768 SGTC_2998 9066762 71.4286 µM -1.55000366440109 0.0503405404948003 no 3143 0.0605703182421951 4525 4945196 SGTC_736 0958-0254 92.6 µM -1.55032729757812 0.0503049675235417 no 3144 0.0605314893090461 4578 6812352 SGTC_2297 7971671 152.32 µM -1.5509854090116 0.0502326913091204 no 3145 0.0604525903371014 4515 909016 SGTC_538 2922-0838 53.3 µM -1.55412677967266 0.0498888342486463 no 3146 0.0600770892622674 4550 777039 SGTC_2723 salbutamol 83.58 µM -1.55827599654689 0.0494375378740026 no 3147 0.0595839182489411 4526 9884233 β2-adrenoceptor agonist SGTC_1069 diphenylcyclopropenone 8.49 µM -1.55998376478772 0.049252738922993 no 3148 0.0593818589278529 4556 65057 A dermal irritant. YDR527W RBA50 SGTC_820 1582-0060 59.9 µM -1.56310166491009 0.0489167716743971 no 3149 0.0590143420510792 4553 3848840 SGTC_1990 st072050 59.8 µM -1.56896118554032 0.0482903389636708 no 3150 0.0583284917336447 4519 17233948 SGTC_1896 st058441 89 µM -1.56983503828655 0.048197468981297 no 3151 0.0582267468870429 4546 688759 SGTC_1777 st045864 34.765 µM -1.57097088293089 0.0480769690717147 no 3152 0.0580947061288051 4548 4691462 SGTC_1199 1638-0010 4.46 µM -1.57259165976949 0.0479054410884504 no 3153 0.0579067000514701 4529 3111136 SGTC_570 0987-0065 62.6 µM -1.57336881035563 0.0478233686279538 no 3154 0.0578167223183372 4397 3104428 SGTC_3340 9146634 11.102 µM -1.58453139531446 0.0466568996077689 no 3155 0.0565364215031808 4523 4907387 SGTC_1365 1672-3266 55.4 µM -1.58484027413966 0.0466249498767037 no 3156 0.0565013146652639 4560 6415873 SGTC_2056 5235370 200 µM -1.58777050429164 0.0463227259737951 no 3157 0.05616912175192 4463 5511916 SGTC_992 3909-8734 162 µM -1.58944980103117 0.0461502335758816 no 3158 0.0559794393860577 4554 4288319 SGTC_2062 5245942 200 µM -1.59388729355538 0.0456969093094185 no 3159 0.0554806404445181 4585 1376160 SGTC_2275 7947463 200 µM -1.59967755924077 0.0451107788504985 no 3160 0.0548350663244512 4499 1225414 SGTC_2645 abamectin 100 µM -1.60921854119208 0.0441581864202774 no 3161 0.0537842817751886 4502 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels. SGTC_733 4069-0007 56.1 µM -1.60985109393924 0.0440956085719433 no 3162 0.0537151839027515 4550 5717425 YNL287W SEC21 SGTC_1111 tnp00062 510.699 nM -1.61002636727212 0.0440782816025794 no 3163 0.0536960500957935 4550 676306 SGTC_499 genistein 192 µM -1.61234676396767 0.0438494115033561 no 3164 0.053443251226453 4645 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger. SGTC_97 0535-0701 19.132 µM -1.62161832708898 0.0429444703292342 no 3165 0.0524425480187686 4456 2832013 YGL099W LSG1 SGTC_2587 piperic acid 92.2 µM -1.62187744285885 0.0429193980226048 no 3166 0.0524147961461431 4493 5370536 SGTC_3021 9087658 49.47 µM -1.62351221492138 0.0427614884133286 no 3167 0.0522399771629005 4578 25237042 SGTC_1387 3342-1166 1.8 µM -1.62484869896809 0.0426327409077638 no 3168 0.0520974007468119 4550 3418228 SGTC_2228 7354201 200 µM -1.62486384218461 0.0426312839141064 no 3169 0.0520957870379125 4655 753451 SGTC_1175 0741-0056 27.6 µM -1.62682490786297 0.0424429413190273 no 3170 0.0518871449925185 4618 765927 SGTC_2328 6201408 200 µM -1.64133743725713 0.0410699744817951 no 3171 0.0503636944484237 4520 2890418 SGTC_3094 9117742 49.47 µM -1.64488653126564 0.0407397500031324 no 3172 0.0499966064843219 4525 17149698 SGTC_2024 5144227 134 µM -1.64821109953691 0.040432374052243 no 3173 0.0496546799659199 4540 3475211 SGTC_1267 0828-0272 9.49 µM -1.65164219845461 0.0401171259067056 no 3174 0.0493037561290039 4613 745334 SGTC_1147 3809-1045 12.3 µM -1.65581725437504 0.0397362197707665 no 3175 0.0488794162421336 4588 325925 SGTC_508 roscovitine 141 µM -1.66295891306937 0.0390914798103568 no 3176 0.0481603301238436 4631 160355 A CDKinase inhibitor. SGTC_955 1216-0110 33 µM -1.66820765156822 0.0386230805745625 no 3177 0.047637256247556 4548 3619719 SGTC_1984 st072354 53.1 µM -1.67013406184517 0.0384523184642531 no 3178 0.04744642115632 4477 5762938 SGTC_990 3985-0011 41.3 µM -1.67513932605692 0.0380115137776378 no 3179 0.0469534493086487 4545 5399565 YGL099W LSG1 SGTC_1710 st031758 61.5 µM -1.67880509164691 0.0376912985874893 no 3180 0.046595017986533 4610 5394341 SGTC_2051 5263410 176 µM -1.68273697424904 0.0373502884651937 no 3181 0.0462130103369257 4544 227584 SGTC_874 0599-0792 117 µM -1.68800419839055 0.0368974186435912 no 3182 0.0457052115084879 4574 765305 SGTC_3171 9103192 49.47 µM -1.68913081708011 0.0368011384466922 no 3183 0.0455971816597348 4645 13018434 SGTC_755 1995-0008 37.3 µM -1.6929425580397 0.0364769116031939 no 3184 0.0452332007713686 4568 689533 SGTC_1240 0356-0016 42.1 µM -1.6982465620992 0.0360296457163268 no 3185 0.0447306179194162 4554 4305613 SGTC_2227 7312221 64.1025 µM -1.70497820584139 0.0354684707642078 no 3186 0.0440992445950052 4689 887188 YOR168W | YOR169C GLN4 | YOR169C SGTC_746 1095-0025 46.6 µM -1.70823513202246 0.0351995449722324 no 3187 0.0437963610804481 4605 6749286 SGTC_2604 4'-hydroxychalcone 11.32 µM -1.71155580882477 0.0349270797891609 no 3188 0.0434892790266685 4568 5282362 SGTC_3187 9109394 49.47 µM -1.7117134399113 0.0349141891454609 no 3189 0.0434747452940854 4591 17098090 SGTC_1347 1493-0251 600 nM -1.7122950200929 0.0348666628725507 no 3190 0.0434211569757818 4630 3986378 SGTC_1230 0170-0365 3.77 µM -1.71253671291796 0.0348469275539643 no 3191 0.043398902458242 4603 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1 SGTC_1905 st060207 84.5 µM -1.71537717671141 0.0346156772516509 no 3192 0.0431380485429183 4580 1948547 SGTC_703 3875-0075 71.8 µM -1.71650725519056 0.034524025501755 no 3193 0.0430346206083424 4635 2850814 SGTC_2838 9002687 71.43 µM -1.72891295637197 0.0335309431788115 no 3194 0.0419123374212253 4585 6457060 SGTC_1190 1486-1332 13 µM -1.73464390002075 0.0330801838360023 no 3195 0.0414019493184802 4602 4150046 SGTC_3099 9120367 49.47 µM -1.73498597350992 0.0330534371883109 no 3196 0.0413716448359825 4625 24824940 SGTC_3161 9100388 49.47 µM -1.74329759852705 0.032409010506364 no 3197 0.0406408223179159 4660 25236368 SGTC_1187 1391-0724 117 µM -1.74647643877098 0.0321653013228081 no 3198 0.0403640988546863 4646 6997986 SGTC_521 r062-0005 13.8 µM -1.74970063627813 0.0319196621412965 no 3199 0.0400849919294385 4549 2832033 SGTC_2105 5350118 200 µM -1.75931597580554 0.0311962913182258 no 3200 0.0392619272852443 4584 2133313 SGTC_2404 5161160 200 µM -1.76026922415804 0.0311253222774783 no 3201 0.0391810848497718 4569 2831543 SGTC_1933 st074711 15.9 µM -1.76162102473688 0.0310249101982463 no 3202 0.0390666746188636 4608 17250958 SGTC_1085 doxorubicin 7.67 µM -1.76279885175055 0.0309376395757619 no 3203 0.0389672105799162 4628 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_515 4092-1064 102 µM -1.76349229540386 0.0308863542308824 no 3204 0.0389087477983656 4577 717353 SGTC_393 acivicin 6.25 µM -1.76426429410693 0.0308293419491963 no 3205 0.0388437462513455 4486 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1 SGTC_3067 9117431 49.47 µM -1.76462772972103 0.030802532320247 no 3206 0.0388131759569031 4614 17150885 SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM -1.7656354038044 0.0307282999478528 no 3207 0.038728518186515 4617 7104 SGTC_2990 9074105 71.4286 µM -1.76953016245245 0.0304427759071186 no 3208 0.0384027209044781 4543 6502001 SGTC_3258 9138477 49.47 µM -1.77114999789878 0.030324674971387 no 3209 0.038267880815924 4647 4970355 SGTC_319 1348-1596 45.5 µM -1.77423514127812 0.0301007897445667 no 3210 0.0380121318772745 4668 5380505 SGTC_3170 9103054 49.47 µM -1.77868771883928 0.0297800890270802 no 3211 0.0376454868777807 4588 16432970 SGTC_1452 4194-0072 190 µM -1.78242125877566 0.0295133673656869 no 3212 0.0373402806542844 4653 1343545 SGTC_1087 pterostilbene 9.05 µM -1.78406760314904 0.0293963851998446 no 3213 0.0372063403861473 4617 5281727 Similar to reservatol, lowers cholesterol. SGTC_1601 4'-hydroxyflavanone 55.5 µM -1.78631760859143 0.0292371323440668 no 3214 0.0370239237059134 4650 165506 SGTC_207 4185-0010 4.486 µM -1.78913723087354 0.0290385749785934 no 3215 0.0367963587443305 4651 3761753 SGTC_1093 fluphenazine 7.97 µM -1.78967796801529 0.0290006246894414 no 3216 0.0367528481262926 4647 6602611 An atypical antipsychotic. SGTC_3046 9092212 49.47 µM -1.78972593750997 0.0289972600612241 no 3217 0.0367489902756168 4678 25236637 SGTC_806 3966-4455 5.86 µM -1.79074522617827 0.028925842783684 no 3218 0.0366670942778812 4612 714982 SGTC_1660 st012960 28.1 µM -1.79261250572187 0.0287953895740488 no 3219 0.0365174526826878 4638 24207266 SGTC_2131 toluylene red 5.2905 µM -1.7940338665474 0.0286964176433765 no 3220 0.0364038817444824 4581 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain. SGTC_15 0266-0086 27.098 µM -1.794478427022 0.0286655202270868 no 3221 0.0363684194494078 4683 1712902 YIL048W NEO1 SGTC_3079 9117512 49.47 µM -1.79759350125049 0.0284497945670851 no 3222 0.0361207244780912 4697 7185044 SGTC_900 1112-0045 141 µM -1.79940322985407 0.0283250884163345 no 3223 0.0359774595218758 4559 56211 YIL048W NEO1 SGTC_578 3460-0051 92 µM -1.80641037156757 0.0278465180693212 no 3224 0.0354271313603725 4660 2876744 SGTC_926 2268-1401 59.4 µM -1.81136879805963 0.0275119553908982 no 3225 0.0350418912669461 4595 2931578 SGTC_815 1582-0027 36.9 µM -1.81310985025953 0.0273952781987413 no 3226 0.034907440109246 4637 3128206 SGTC_1675 st018485 24.5 µM -1.81378793129618 0.0273499481609625 no 3227 0.0348551906325824 4616 3323024 SGTC_56 0957-0365 83.25 µM -1.81537467375158 0.0272441180969583 no 3228 0.034733175206626 4577 6752360 SGTC_2706 st078239 82.5 µM -1.81541979496889 0.0272411136748614 no 3229 0.034729710664457 4611 15434492 SGTC_2356 9061756 188.97 µM -1.82221919339224 0.0267915202666671 no 3230 0.0342108667179588 4651 20104043 SGTC_2924 9010168 62.78 µM -1.8233289200312 0.0267187337707008 no 3231 0.0341267943502889 4613 2993929 SGTC_2951 9072950 58.06 µM -1.82425128312991 0.0266583621148399 no 3232 0.0340570458900969 4576 16488155 SGTC_891 0929-0073 133 µM -1.83335537965523 0.0260685594117077 no 3233 0.0333748693300926 4654 5603632 SGTC_17 0960-0276 49.807 µM -1.8406709882592 0.0256025670455089 no 3234 0.0328348939465915 4636 6821114 SGTC_3152 9099253 49.47 µM -1.84451210431242 0.0253606995495509 no 3235 0.0325542717192315 4493 25236131 SGTC_3036 9090181 49.47 µM -1.84754705314773 0.0251709510930346 no 3236 0.0323339476216224 4691 25236586 SGTC_1986 st071812 45 µM -1.84871840663788 0.0250980356458692 no 3237 0.0322492422092931 4602 11838594 SGTC_3156 9099931 49.47 µM -1.85080121696282 0.0249688203163073 no 3238 0.0320990779732087 4670 18111053 SGTC_1767 st044992 70.3 µM -1.85154442444139 0.0249228477479997 no 3239 0.0320456349357272 4642 9600693 SGTC_3229 9132204 49.47 µM -1.85460912996448 0.0247340234504124 no 3240 0.0318260317064808 4719 17682924 SGTC_264 promethazine 12.5 mM -1.85863453984594 0.0244878324202296 no 3241 0.0315394789046965 4514 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3 SGTC_679 0422-0091 41.4 µM -1.86045948770479 0.0243768994513572 no 3242 0.0314102725267847 4658 627384 YHR062C RPP1 SGTC_2943 9068529 45.32 µM -1.86109907300501 0.0243381210071519 no 3243 0.0313650935554968 4593 3270634 SGTC_878 0828-0289 13.7 µM -1.86356249308041 0.0241892459618113 no 3244 0.0311915844540168 4620 745350 YLR208W SEC13 SGTC_850 0388-0143 75.9 µM -1.88007731044754 0.0232108128563861 no 3245 0.0300487711344448 4661 67273 SGTC_2483 5729050 27.16 µM -1.88800698844606 0.0227529825036636 no 3246 0.0295125061329824 4626 2865180 SGTC_2826 7992541 19.48 µM -1.88903558588564 0.0226941564855713 no 3247 0.0294435302654162 4636 2985066 SGTC_2411 st077133 39.94 µM -1.8954288078213 0.0223313923012471 no 3248 0.0290178075831217 4613 1403142 YNL221C POP1 SGTC_509 pifithrin 175 µM -1.89963761624946 0.0220952560692962 no 3249 0.0287403461083718 4719 4817 A p53 inhibitor. SGTC_1309 pyrazolanthrone 13.4 µM -1.90123375826268 0.0220062569956291 no 3250 0.0286357005926117 4661 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14 SGTC_470 aa-861 153 µM -1.90594193796146 0.0217454953625482 no 3251 0.0283288695707147 4618 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor. SGTC_1728 st035614 33.7865 µM -1.90756351715181 0.021656290936006 no 3252 0.0282238271226421 4605 15945546 SGTC_1357 1503-1303 39.5 µM -1.91121535381875 0.0214565320213486 no 3253 0.0279884557807561 4637 292895 SGTC_2321 7390090 138.78 µM -1.91387403557234 0.0213120813392384 no 3254 0.0278181263580563 4655 649046 SGTC_2561 acetosyringone 100 µM -1.91764464313476 0.0211086286261987 no 3255 0.0275780426730702 4622 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent. SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM -1.92211252144563 0.0208696823288657 no 3256 0.0272958004245296 4630 6857784 SGTC_2293 7624732 200 µM -1.92468457197289 0.0207331680363349 no 3257 0.0271344158858132 4564 894453 SGTC_2877 9040724 71.43 µM -1.93107688173342 0.0203971609368765 no 3258 0.0267367727375703 4627 6463895 SGTC_2108 5365811 200 µM -1.93221197784209 0.0203379805458629 no 3259 0.0266666736964347 4672 780283 SGTC_655 k060-0012 42 µM -1.93290554090098 0.02030189200154 no 3260 0.0266239175908243 4684 5994525 SGTC_2967 9089538 49.85 µM -1.93472322809113 0.0202075687676415 no 3261 0.0265121341981852 4650 728216 SGTC_1648 st011736 69.8 µM -1.94473470116009 0.0196946884299571 no 3262 0.0259034583866135 4660 2855514 SGTC_1699 st031318 29.054 µM -1.94540972662008 0.0196605086755795 no 3263 0.0258628425128468 4713 5340658 SGTC_2591 skatole 100 µM -1.94953975506686 0.0194524805847924 no 3264 0.0256154999939433 4646 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite. SGTC_2119 5528445 120.635 µM -1.96260777841014 0.0188065256799143 no 3265 0.0248458831042254 4681 791935 SGTC_2734 clemastine 41.6 µM -1.96788266933506 0.0185510059236813 no 3266 0.0245407696554971 4740 26987 Clemastine is a selective histamine H1 antagonist. SGTC_1337 1486-1011 40.3 µM -1.96894588870732 0.0184998622895762 no 3267 0.0244796526015109 4694 X1337 SGTC_143 4032-1194 15.74 µM -1.97135781666858 0.0183842872119424 no 3268 0.0243414812359084 4687 1806963 SGTC_568 1193-0097 7.48 µM -1.98565555127376 0.0177117220995674 no 3269 0.0235357918214452 4490 3646150 SGTC_889 0919-1524 82.7 µM -1.98801250752347 0.0176028915077357 no 3270 0.0234051533484727 4699 3905452 SGTC_290 2043-6722 48.1 µM -2.00578368574028 0.0168005507838971 no 3271 0.0224396660002214 4691 773758 YLR208W SEC13 SGTC_3077 9117319 49.47 µM -2.01142482504142 0.0165524930097221 no 3272 0.0221403016809487 4649 17154678 SGTC_554 4483-2211 187 µM -2.02295376434761 0.0160552680893145 no 3273 0.0215389573184054 4715 747107 SGTC_1626 st003712 1.76 µM -2.02633960386493 0.0159116962334154 no 3274 0.0213649977311552 4681 24207035 SGTC_888 0916-0002 6.97 µM -2.02963543660834 0.0157729996589878 no 3275 0.0211968050340066 4688 2802138 YIL048W NEO1 SGTC_1772 st048439 82.2 µM -2.04504437040921 0.0151382295727657 no 3276 0.0204252419527189 4713 2927068 YDL195W SEC31 SGTC_2060 5238662 140 µM -2.04985828979317 0.0149444747683689 no 3277 0.0201891307371496 4665 790130 SGTC_2971 9092186 9.93 µM -2.06427919427586 0.0143767577832625 no 3278 0.0194956262596007 4652 25236400 SGTC_792 4534-1957 155 µM -2.06462791190622 0.014363262762858 no 3279 0.019479110091937 4666 1717904 SGTC_2310 7668677 200 µM -2.06652449905132 0.0142900575874759 no 3280 0.0193894907885266 4648 2197143 SGTC_1112 tnp00069 1.16933 µM -2.07008712945968 0.0141534143428335 no 3281 0.0192220929644849 4689 145826 SGTC_2317 5986382 200 µM -2.07205718688548 0.0140783380953429 no 3282 0.019130054182825 4695 877883 SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM -2.07217729062219 0.014073772223142 no 3283 0.0191244552143208 4716 4174840 SGTC_756 0508-1999 28.3 µM -2.08143744864883 0.0137255584062117 no 3284 0.0186969419686013 4708 6753853 SGTC_2514 salinomycin 42.74 µM -2.08431949424317 0.013618711338924 no 3285 0.0185655576371781 4681 23682228 A polyether potassium ionophore. SGTC_1041 0206-0046 107 µM -2.0879336233049 0.0134857385230699 no 3286 0.0184019113253775 4694 50494 SGTC_2922 7999257 32.47 µM -2.09389627565412 0.0132688074041812 no 3287 0.018134610560397 4687 2988377 SGTC_1098 clofazimine 15.1 µM -2.09507714517298 0.0132262048928445 no 3288 0.0180820676225006 4730 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2 SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM -2.10935976450979 0.0127202137711129 no 3289 0.0174567698579008 4724 688788 SGTC_420 mitomycin C 81.9 mM -2.11670138298522 0.0124667020319495 no 3290 0.0171425996999299 4696 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_172 1112-0046 2.638 µM -2.12226499731051 0.0122775113166125 no 3291 0.0169077455439283 4703 2802135 YIL048W NEO1 SGTC_3098 9119039 49.47 µM -2.14447842500122 0.0115467260979856 no 3292 0.0159972861648474 4707 17161528 SGTC_1582 3',3',6'-trihydroxyflavone 74 µM -2.15154722022744 0.0113222383757457 no 3293 0.0157165164576889 4703 688803 SGTC_1377 2944-0135 198 µM -2.15771283217668 0.0111295402128367 no 3294 0.0154750828222567 4706 1894137 SGTC_596 1155-0152 116 µM -2.15801929297069 0.0111200370312536 no 3295 0.015463165912956 4734 280313 SGTC_1943 st076331 65.2 µM -2.1645937717141 0.0109178587658418 no 3296 0.015209404199521 4698 24208415 SGTC_2170 morpholine 200 µM -2.17549642568474 0.0105896277985958 no 3297 0.0147964678374695 4732 121171 Reacts with secondary amines. SGTC_556 4058-0063 51.5 µM -2.2152065172559 0.00946571574957803 no 3298 0.0133729463798229 4733 6615692 SGTC_2679 rapamycin 1 nM -2.22605927389297 0.00917730707085004 no 3299 0.0130051056939653 4592 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2 SGTC_2529 gangaleoidin 93.61 µM -2.22620740396904 0.00917342436627182 no 3300 0.0130001461319712 4716 4565183 SGTC_145 3737-0113 38.366 µM -2.23297020577809 0.00899768609692648 no 3301 0.0127754546057944 4705 6849351 SGTC_2720 fluspirilene 36.88 µM -2.23932196118779 0.00883532201015695 no 3302 0.0125674874766381 4733 3396 An atypical antipsychotic. SGTC_3085 9117376 49.47 µM -2.24882641529212 0.00859716474290406 no 3303 0.0122617710392592 4754 16480349 SGTC_1844 rapamycin 4 nM -2.26635887163395 0.00817258835861057 no 3304 0.0117147097984771 4581 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2 SGTC_2059 5238311 157 µM -2.29712170548809 0.00747199719292053 no 3305 0.0108059139415638 4712 703021 SGTC_2031 5180455 200 µM -2.30358522797601 0.00733171129557115 no 3306 0.0106229689296687 4744 29949 SGTC_1135 dihydrocapsaicin 536.708 nM -2.30920205321434 0.00721169312166843 no 3307 0.0104661858469614 4686 107982 A Capsaicinoid. SGTC_903 1134-0042 114 µM -2.32398824238226 0.00690399337898488 no 3308 0.0100630621058887 4742 701009 SGTC_522 1273-0010 11.6 µM -2.3395632673075 0.0065924711693821 no 3309 0.00965315065071856 4738 5705015 SGTC_288 1315-0019 35.1 µM -2.34045651387688 0.00657498789876728 no 3310 0.00963009061352261 4751 6811474 SGTC_1213 1315-0166 115 µM -2.34284754576157 0.00652839048411736 no 3311 0.00956860054200423 4728 768401 SGTC_105 0111-0055 734.78 µM -2.35306681145489 0.00633250889563119 no 3312 0.00930964415464933 4745 5179370 SGTC_783 0848-0141 92.7 µM -2.36341694677591 0.00613943959030947 no 3313 0.00905364239473572 4721 6755076 YHR007C | YLR033W ERG11 | RSC58 SGTC_339 3091-4833 71.4 µM -2.37718772055334 0.00589065523407832 no 3314 0.00872260373537675 4588 3240077 SGTC_1468 k284-1086 134 µM -2.38971397535827 0.00567216342965747 no 3315 0.00843074929055556 4737 15996457 SGTC_2074 5212007 75.395 µM -2.41564400837771 0.00524260215328017 no 3316 0.00785370492454998 4738 758611 SGTC_849 0386-0493 241 µM -2.42881831105702 0.0050356445478547 no 3317 0.00757406068743827 4756 726119 SGTC_2047 4141938 200 µM -2.48622475313161 0.0042162888911589 no 3318 0.00645531995366552 4771 3807862 SGTC_2292 7671323 168.05 µM -2.49455060996243 0.00410792335089 no 3319 0.00630583700630575 4760 937504 SGTC_962 1254-0300 21.5 µM -2.50210046672733 0.00401181985592343 no 3320 0.00617294423949621 4757 7340576 SGTC_1605 st000082 49.1 µM -2.5246462666858 0.00373669835061729 no 3321 0.005790739929955 4758 1114022 SGTC_2393 9031399 185.94 µM -2.54565257338141 0.00349571777321978 no 3322 0.00545368431623266 4742 1526623 YDL150W RPC53 SGTC_407 eburnamonine 100 µM -2.5866473406737 0.00306524680198736 no 3323 0.00484573628606106 4702 3195 SGTC_85 0868-0259 160.055 µM -2.59815461139546 0.00295331563133178 no 3324 0.00468631409548905 4758 83173 SGTC_2351 9026858 72.31 µM -2.6218224974394 0.00273460251325552 no 3325 0.00437304850079929 4729 1409300 SGTC_354 2783-3500 4.88 µM -2.65551930569452 0.00244840931380154 no 3326 0.00395932003870108 4767 6740761 SGTC_144 4161-2749 112.381 µM -2.66574246915068 0.00236710326506764 no 3327 0.00384092569710403 4779 797501 YMR168C CEP3 SGTC_2067 5224629 34.075 µM -2.67062785108735 0.0023291189805875 no 3328 0.00378547666409052 4762 2835000 SGTC_516 3992-2719 87.3 µM -2.68553868964685 0.00221657402589162 no 3329 0.00362064952392199 4730 5350887 YDR037W KRS1 SGTC_1328 1441-0025 69.2 µM -2.76301569128933 0.00170727013764904 no 3330 0.0028635006588836 4791 4562601 SGTC_768 0384-0033 77.3 µM -2.77951600598352 0.00161363370630902 no 3331 0.00272199852847227 4773 3965305 YMR134W ERG29 SGTC_1628 st004252 77.7 µM -2.78809528770339 0.00156681944520864 no 3332 0.00265094733158441 4777 692968 SGTC_1331 1472-0049 76.2 µM -2.8154090656949 0.0014259034549434 no 3333 0.00243575906816335 4779 24051409 SGTC_180 1486-1293 102.781 µM -2.82057890039381 0.00140057127500514 no 3334 0.00239685417051634 4753 4140536 SGTC_112 phenothiazine 287.218 µM -2.84392819729867 0.00129120146404649 no 3335 0.00222805443222276 4777 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.  SGTC_1732 st034308 51.822 µM -2.86030173612134 0.00121922716419002 no 3336 0.00211619051655406 4746 830119 SGTC_2291 7917025 104.35 µM -2.91252784529054 0.001013486447333 no 3337 0.00179258117206501 4747 2964612 SGTC_514 4466-0038 2.65 nM -2.93499892284867 0.000935190680025402 yes 3338 0.00166774422919431 4697 5722064 SGTC_1800 st050079 29.0735 µM -2.94410602915512 0.000905072087203253 yes 3339 0.00161944508735391 4725 3645560 SGTC_1818 st052136 56.3 µM -2.95282413180662 0.000877077647123431 yes 3340 0.00157440650208253 4650 674169 SGTC_909 3448-9333 149 µM -3.03165074316529 0.000657792724773925 yes 3341 0.00121610221316619 4770 3344074 SGTC_867 0518-0118 155 µM -3.04981948215569 0.000615017223405541 yes 3342 0.00114489475042004 4786 6848158 SGTC_1092 toremifene 6.32 µM -3.07973089166129 0.000550152741373934 yes 3343 0.00103593853475919 4801 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_331 k048-0133 24.5 µM -3.18740156653936 0.000365472006048098 yes 3344 0.00071778656036332 4799 6813582 SGTC_1607 st000305 50.6 µM -3.23783626038046 0.000300483550579289 yes 3345 0.00060219956306482 4797 5457690 SGTC_660 4031-1742 102 µM -3.25765313503141 0.000278028542192248 yes 3346 0.000561688139941155 4762 6738706 SGTC_1792 st045773 43.6 µM -3.3105215237129 0.000225535795882775 yes 3347 0.000465611450889453 4799 2919270 SGTC_77 0828-0286 12.516 µM -3.3331666180931 0.000206014521297892 yes 3348 0.000429317526065686 4766 745345 SGTC_1754 st042065 16.137 µM -3.4515711981625 0.000127193856821863 yes 3349 0.00027866634530614 4735 1126236 YIL048W NEO1 SGTC_3037 9091026 49.47 µM -3.70863466970625 4.24080908602017e-05 yes 3350 0.000104189912181665 4773 25236398 YIL048W NEO1 SGTC_1604 st002052 72.4 µM -3.86071554154148 2.14185643530034e-05 yes 3351 5.65277302080633e-05 4806 6254834 YHR062C RPP1 SGTC_2342 7990637 118.86 µM -3.95592483763516 1.37905804531642e-05 yes 3352 3.8119565197228e-05 4801 2033102 YER133W GLC7