SGTCid condition conc unit IOC3|YFR013W.score IOC3|YFR013W.strain.pval IOC3|YFR013W.strain.significant IOC3|YFR013W.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene SGTC_2123 5259487 200 µM 5.94763650113259 1.26015438534975e-08 yes 1 1.36020941490789e-09 1 2173474 SGTC_540 1187-0821 17.3 µM 5.94727258089616 1.26266917958858e-08 yes 2 1.36323589170163e-09 2 847520 SGTC_2749 bexarotene 57.39 µM 5.8949724970619 1.67953957728667e-08 yes 3 1.87371896503557e-09 5 82146 An retinoic acid receptor inhibitor. SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM 5.511503246189 1.2634213868481e-07 yes 4 1.77890933102833e-08 2 4213774 SGTC_322 k048-0136 19.3 µM 5.29371723468701 3.75115824499066e-07 yes 5 5.99273560666911e-08 5 6823282 SGTC_2116 5511452 16.8835 µM 5.06718024888612 1.11310203254015e-06 yes 6 2.01875962637289e-07 4 870744 SGTC_1532 4',5'-dihydroxyflavone 78.7 µM 5.01225595505405 1.43917212796469e-06 yes 7 2.68977903083039e-07 13 165521 SGTC_2293 7624732 200 µM 4.96291444490012 1.80871047793226e-06 yes 8 3.47215883507718e-07 7 894453 SGTC_1051 3253-3903 78 µM 4.61077007155208 8.68696625114001e-06 yes 9 2.00590035415559e-06 9 5509239 SGTC_169 k015-0017 16.025 µM 4.57057941784082 1.03194493879343e-05 yes 10 2.43188776351947e-06 14 1840002 SGTC_664 1222-0054 14.9 µM 4.45441305264814 1.68417001977499e-05 yes 11 4.20615054130036e-06 29 6813991 SGTC_2977 9011197 71.43 µM 4.45251861013516 1.69751191430299e-05 yes 12 4.24344409513338e-06 11 2704722 SGTC_2785 7756463 72.73 µM 4.42623293554471 1.89330945890355e-05 yes 13 4.79464866290501e-06 17 2201551 SGTC_2964 9083345 53.42 µM 4.41541566421363 1.97995712304315e-05 yes 14 5.04080398868178e-06 13 17741579 SGTC_1061 3448-9325 110 µM 4.38708518932461 2.2250743954968e-05 yes 15 5.74399018052285e-06 15 723482 SGTC_2274 7947094 46.08 µM 4.36428092224075 2.44301250004817e-05 yes 16 6.37707965041544e-06 20 2971028 SGTC_2730 imipramine 71.33 µM 4.32631353931326 2.85137862877012e-05 yes 17 7.58127779042743e-06 12 3696 A tricyclic antidepressant. SGTC_2003 4023581 200 µM 4.2547428636155 3.80293744445227e-05 yes 18 1.04644693918216e-05 28 16641307 SGTC_85 0868-0259 160.055 µM 4.20706602362357 4.59578746431009e-05 yes 19 1.29353788053209e-05 7 83173 SGTC_1956 st077085 54 µM 4.20577279325409 4.61932788507476e-05 yes 20 1.30095765918667e-05 14 24208685 SGTC_3201 9113999 49.47 µM 4.19451462849932 4.82912387717999e-05 yes 21 1.36728252247792e-05 28 16649224 SGTC_3255 9139072 49.47 µM 4.14212396206084 5.9293422035141e-05 yes 22 1.72052130833035e-05 15 17646060 SGTC_502 l-744,832 89.3 µM 4.06087230617245 8.11351147013411e-05 yes 23 2.44448535866252e-05 35 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.  SGTC_2914 7968218 45.32 µM 4.05266363878245 8.37203836874834e-05 yes 24 2.53188906888218e-05 12 2977111 SGTC_1829 berberine 14.4 µM 4.03171867751687 9.06723801250821e-05 yes 25 2.76852214030051e-05 20 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_2976 9009005 19.48 µM 4.01381706836755 9.70408497088059e-05 yes 26 2.98723278019124e-05 29 2993148 SGTC_2831 7999036 19.48 µM 3.9692324145518 0.000114776374156088 yes 27 3.60522637501765e-05 46 2988270 SGTC_3140 9094243 49.47 µM 3.94047324163455 0.000127785031348123 yes 28 4.0660510897208e-05 24 19291112 SGTC_2044 5102272 200 µM 3.92705647761421 0.000134315699211079 yes 29 4.29958971423142e-05 10 592666 SGTC_1260 0700-1617 7.75 µM 3.92489101138395 0.000135398625842736 yes 30 4.33845068845708e-05 30 2853078 SGTC_2480 5767542 37.17 µM 3.84666271565327 0.0001804782269658 yes 31 5.98688107477994e-05 12 2867358 SGTC_3087 9117406 49.47 µM 3.80433493119693 0.000210379806357832 yes 32 7.10928447035013e-05 21 42546093 SGTC_1231 0242-0792 125 µM 3.80181134890518 0.000212301166156115 yes 33 7.18210422594471e-05 22 3707635 SGTC_573 3702-0553 84.7 µM 3.76812883864189 0.000239565158479786 yes 34 8.22379057329379e-05 19 1222756 SGTC_2059 5238311 157 µM 3.76676065567093 0.000240738802586857 yes 35 8.26897043998191e-05 33 703021 SGTC_465 cgp-37157 41 µM 3.75772337047455 0.000248626811731558 yes 36 8.57331425500383e-05 12 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange. SGTC_2413 inermin 26.06 µM 3.69701585260337 0.000308188200141292 yes 37 0.000109074362389064 65 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1 SGTC_334 1502-1024 68.5 µM 3.66567327382527 0.000343899989343643 yes 38 0.000123344357269131 18 3296216 SGTC_530 4358-1714 28 µM 3.53469711504702 0.000538844346570678 yes 39 0.000204121408830107 58 1564641 SGTC_1195 1502-0147 41.1 µM 3.52329310176084 0.000559942405098959 yes 40 0.000213109863228388 42 817940 SGTC_3334 9142812 21.919 µM 3.48824490848393 0.000629658245961904 yes 41 0.000243101255560516 39 45283678 SGTC_1660 st012960 28.1 µM 3.47560955723163 0.000656697999105683 yes 42 0.000254846878489874 51 24207266 SGTC_1390 3413-2614 145 µM 3.47387473502964 0.000660493079032382 yes 43 0.000256500233518771 37 3421432 SGTC_2757 clomiphene 4.22 µM 3.44835077054462 0.00071871934472037 yes 44 0.000282010520925214 63 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined. SGTC_529 4076-0302 30.3 µM 3.38850684806687 0.000874262215655959 yes 45 0.000351371370282767 30 5816522 SGTC_2168 5727979 200 µM 3.38189219041483 0.000893233189472651 yes 46 0.00035994195505104 34 695210 SGTC_316 k060-0003 58.6 µM 3.37822338431311 0.000903917827539934 yes 47 0.000364778949594197 27 6152314 SGTC_1543 azetidyl-2-carboxylic acid 198 µM 3.37632055311915 0.000909505570694057 yes 48 0.000367311376817152 31 16486 A toxic proline analog. SGTC_1777 st045864 34.765 µM 3.32503841541187 0.00107258801290555 no 49 0.0004420317650487 24 4691462 SGTC_95 0471-0001 561.058 µM 3.32475799040272 0.00107354920321488 no 50 0.000442476575878857 48 4015405 SGTC_1907 st060210 83.7 µM 3.32179483123369 0.00108375415785567 no 51 0.000447202170293485 47 688793 SGTC_1555 citronellol 128 µM 3.30277493650859 0.00115140325707064 no 52 0.000478665948399206 12 8842 A terpine precursor. SGTC_480 am 92016 50 µM 3.300513058623 0.00115970048061054 no 53 0.000482541111312636 33 2129 K+ channel blocker. SGTC_857 0438-0306 1.35 µM 3.29653296978075 0.00117443367241938 no 54 0.00048943062410884 24 4686136 SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM 3.2866695247399 0.00121168707324983 no 55 0.000506898660678581 75 676296 Flavone; oxidizing agent. SGTC_2771 fluoxetine 41.05 µM 3.25853404115852 0.00132397379339586 no 56 0.0005599471986639 38 3386 A selective serotonin reuptake inhibitor. SGTC_1102 cgs 12066b 26.1 µM 3.25317310718051 0.00134641844171607 no 57 0.000570619750574458 21 6438352 A 5-HT1B full agonist. SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM 3.23776464607723 0.0014128787715854 no 58 0.000602350737698059 63 551469 SGTC_2157 5649910 96.377 µM 3.23363992253374 0.00143117096333056 no 59 0.000611117239287461 47 2858091 SGTC_1199 1638-0010 4.46 µM 3.20335265170547 0.0015722510981937 no 60 0.00067918765895763 56 3111136 SGTC_1701 st028638 40.4 µM 3.20313612265102 0.00157330382392436 no 61 0.000679698548905613 39 3490878 SGTC_2217 6934799 96.0675 µM 3.20167722885146 0.00158041347122968 no 62 0.000683149989767978 16 675606 SGTC_2115 tiliquinol 12.7705 µM 3.1825433888817 0.00167640851093872 no 63 0.000729938202260975 27 71208 A bioactive hydroxyquinoline. SGTC_2265 7929201 200 µM 3.17857506960283 0.00169697063844068 no 64 0.000740004438443131 54 1265108 SGTC_265 mycophenolic acid 32.932 µM 3.17304151567976 0.00172602655401155 no 65 0.000754254759737553 53 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1 SGTC_1619 st003326 88.7 µM 3.17145987371868 0.00173441434868021 no 66 0.000758374103949175 40 2849032 SGTC_414 piperonyl butoxide 100 µM 3.17059110802098 0.00173903737275706 no 67 0.000760645589137863 28 5794 A potent inhibitor of cytochrome P450. SGTC_2694 st077685 81.9 µM 3.1393289809371 0.00191304453442981 no 68 0.00084667611968525 61 2838096 SGTC_2643 anethole 100 µM 3.10928238400182 0.00209504648858788 no 69 0.00093771190614783 45 637563 An anti-fungal, anti-helmenthic and channel blocker. SGTC_1612 st002233 45.4 µM 3.0973116957318 0.00217183140120552 no 70 0.000976422102369083 57 1035021 SGTC_1099 5-nonyloxytryptamine 2.85 µM 3.0916938327994 0.00220873887279059 no 71 0.000995090006165272 55 23581825 A 5-HT1D beta serotonin receptor agonist. SGTC_1052 3253-3998 198 µM 3.06352899932383 0.00240248250168622 no 72 0.00109371501550958 65 5450317 SGTC_2502 avocadyne acetate 18.59 µM 3.06335516377391 0.00240372462256547 no 73 0.00109435062718253 77 3952079 SGTC_2022 5136654 200 µM 3.03921062771414 0.00258199914967885 no 74 0.00118599476762962 59 1713771 SGTC_1445 4239-0156 97.7 µM 3.03755720592279 0.00259463388276511 no 75 0.00119252065033075 74 4008346 SGTC_1320 1313-0481 95.3 µM 3.00556878230366 0.00285032835355316 no 76 0.00132542317164478 56 6813365 YLR208W SEC13 SGTC_939 1165-0479 45.3 µM 2.99989647889019 0.00289797142958541 no 77 0.00135035689274443 92 1377347 SGTC_2085 5307070 144.047 µM 2.99909562186931 0.00290475555903648 no 78 0.00135391153999745 65 2840351 SGTC_1712 st032288 53.4 µM 2.97330093055811 0.00313106809976368 no 79 0.0014730772281058 270 2883011 SGTC_1955 wogonin 32.4 µM 2.96138797356331 0.00324084883910797 no 80 0.00153127941800522 56 5281703 A flavanone. SGTC_1526 st051518 75 µM 2.94902848042867 0.00335839254193291 no 81 0.00159387298920439 59 673993 SGTC_3123 9126162 49.47 µM 2.93640999259425 0.00348233920098119 no 82 0.00166017580298224 52 25239884 SGTC_928 2764-0428 58.7 µM 2.93406505413191 0.00350582023829151 no 83 0.00167277040096912 115 662578 SGTC_15 0266-0086 27.098 µM 2.91550799625702 0.00369671344711247 no 84 0.00177555003508396 131 1712902 YIL048W NEO1 SGTC_419 nsc-638432 893 µM 2.89457926956439 0.00392314840678484 no 85 0.00189833516947334 49 368090 SGTC_565 1418-0001 44.5 µM 2.8891053567439 0.00398438655569913 no 86 0.00193169804065439 80 2862145 SGTC_2072 5231554 129 µM 2.85572420787114 0.00437670650893695 no 87 0.00214693968954213 44 789545 SGTC_2036 5160441 105 µM 2.85276534889142 0.00441309374936596 no 88 0.00216703057875932 141 134534 YIL048W NEO1 SGTC_1030 k029-0042 36.7 µM 2.83551620894324 0.00463064955432177 no 89 0.00228758466820638 101 6080581 SGTC_162 k030-0015 37.8 µM 2.83392203644696 0.00465123143720026 no 90 0.00229902741462846 54 1809920 YMR134W ERG29 SGTC_2370 9071495 200 µM 2.82152513825001 0.00481408945749225 no 91 0.00238979457011454 94 21791103 SGTC_2586 curcumin 80 µM 2.80385743133497 0.00505497493017008 no 92 0.00252476139472575 135 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40 SGTC_792 4534-1957 155 µM 2.80344338801072 0.0050607465666869 no 93 0.00252800538559717 92 1717904 SGTC_2782 7736369 71.43 µM 2.77893705079278 0.00541298423094974 no 94 0.00272685463308474 117 2950836 YOL077C BRX1 SGTC_2557 derrustone 83.84 µM 2.77721687326496 0.00543850850314712 no 95 0.00274132914451008 112 629853 An antioxidant. SGTC_1461 k072-0203 53.8 µM 2.76509061721599 0.0056214949822974 no 96 0.00284534924473505 78 5418714 SGTC_353 1988-1175 58.3 µM 2.76172252938326 0.00567328057147559 no 97 0.002874865971527 91 2788357 SGTC_2995 9067767 71.4286 µM 2.75882549133846 0.00571816196314241 no 98 0.00290047517008286 82 11673567 SGTC_5 0352-0601 109.883 µM 2.75668710334666 0.00575149210804943 no 99 0.00291950980817348 53 762456 SGTC_2769 toremifene 3.73 µM 2.75268504952018 0.00581433400219061 no 100 0.00295543652207513 77 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM 2.74616717128424 0.00591798503289184 no 101 0.00301480154939211 109 91467 include heat shock SGTC_2922 7999257 32.47 µM 2.72512038450271 0.00626395948150311 no 102 0.00321390227830904 60 2988377 SGTC_1474 0330-0125 5.35 µM 2.72191496887875 0.00631819372921071 no 103 0.00324524201977022 85 X1474 SGTC_2427 5545055 42.75 µM 2.71011381232509 0.00652146355825511 no 104 0.0033630062059648 84 5372858 SGTC_2789 5281112 71.43 µM 2.70888913987357 0.0065428857469117 no 105 0.00337544464300182 123 765948 SGTC_2031 5180455 200 µM 2.70580009215663 0.00659719661385193 no 106 0.00340700256619182 66 29949 SGTC_3099 9120367 49.47 µM 2.70318124812157 0.00664355229218233 no 107 0.00343396424811988 76 24824940 SGTC_1254 0550-0035 264 µM 2.69809163655339 0.00673446682015312 no 108 0.00348691204462725 91 15121435 SGTC_750 4073-0104 132 µM 2.69607886700222 0.00677072270742338 no 109 0.00350805263775155 60 22330957 SGTC_3028 9087778 49.47 µM 2.68303372556024 0.00700991267921844 no 110 0.0036478816271691 75 17217395 SGTC_1367 1812-0510 76.9 µM 2.66705261343443 0.00731307801857363 no 111 0.00382598458626864 99 1142582 YDR527W RBA50 SGTC_1640 st009078 66.4 µM 2.66273349657845 0.00739697171773358 no 112 0.00387543868500119 67 690618 SGTC_765 1319-0117 244 µM 2.66119156379109 0.00742712671833259 no 113 0.00389323215932158 75 3487746 YGL099W LSG1 SGTC_1300 1094-0077 113 µM 2.66037186779013 0.00744320126166701 no 114 0.00390272099113482 64 5532636 SGTC_3101 9120531 49.47 µM 2.63372342073286 0.00798276045627173 no 115 0.00422271258690204 123 24824904 SGTC_1208 2323-2347 50.3 µM 2.61467483343556 0.00838923665351218 no 116 0.00446562189339159 75 5412760 SGTC_3122 9126309 49.47 µM 2.59299179553503 0.00887394301082498 no 117 0.00475725201561198 68 17591206 SGTC_2604 4'-hydroxychalcone 11.32 µM 2.57649080330852 0.00925908471347499 no 118 0.00499044302858485 131 5282362 SGTC_3234 9132280 49.47 µM 2.57485552258409 0.00929803816634427 no 119 0.00501409829422754 110 17612295 SGTC_472 calcifediol 10 µM 2.56977386020436 0.00942000327694528 no 120 0.00508824604996895 54 5283731 A vitamin D metabolite. SGTC_2824 7998404 51.95 µM 2.56355304383927 0.00957121236787289 no 121 0.00518034340866928 118 837851 SGTC_3345 9148410 3.559 µM 2.56089772002527 0.00963639860703669 no 122 0.00522010436912622 61 4903596 SGTC_378 3970-0959 8.33 µM 2.55436929564896 0.00979831874551245 no 123 0.00531901805703337 103 6615653 SGTC_1591 genipin 88.4 µM 2.53667515835141 0.0102491794359316 no 124 0.00559553715281622 83 442424 A DNA cross-linking agent. SGTC_526 4469-0568 170 µM 2.53158975083811 0.010382062232672 no 125 0.00567733771415695 125 2901964 SGTC_1020 4335-0961 93.3 µM 2.52149435552054 0.0106503131267755 no 126 0.00584287751327094 93 669075 SGTC_1690 st023502 41.2 µM 2.50399269411534 0.0111296800811656 no 127 0.00614002849541679 85 24207482 SGTC_3338 9144300 39.5675 µM 2.50395239073636 0.0111308052886961 no 128 0.00614072795835576 111 4901274 SGTC_2543 pimpinellin 60.67 µM 2.49540549380778 0.0113716673178567 no 129 0.00629066321789651 115 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo. SGTC_2496 diffractaic acid 79.83 µM 2.48693560676408 0.0116148140930405 no 130 0.0064424359356807 134 94870 An apoptosis inducer which activates caspases. SGTC_1952 st077036 64.1 µM 2.48629392253075 0.0116334176439688 no 131 0.0064540652777856 134 2937007 SGTC_233 rapamycin 362 pM 2.481804892406 0.0117642874843926 no 132 0.00653594136954514 88 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C SGTC_1261 0712-0010 12.7 µM 2.47550564778322 0.0119500843601139 no 133 0.00665238286957596 139 2840123 SGTC_1146 3579-1023 7 µM 2.47486374595884 0.0119691594412258 no 134 0.00666435076021572 120 X1146 SGTC_2083 5306046 65.942 µM 2.47214353302589 0.0120502880277145 no 135 0.00671527903967795 160 539837 SGTC_572 0960-0087 17.7 µM 2.46268514574204 0.0123361005368914 no 136 0.00689504770683945 168 6796365 SGTC_2908 7930301 100 µM 2.45919425055688 0.0124430619769226 no 137 0.00696246256341186 150 2223178 SGTC_1104 tacrolimus 29.8 µM 2.45871969247889 0.0124576643253579 no 138 0.0069716718356558 123 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41 SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM 2.45512143345666 0.012568867862973 no 139 0.00704185021380506 134 6708760 SGTC_2726 cimetidine 79.27 µM 2.44975180523165 0.0127364129255625 no 140 0.00714773576004469 63 2756 A P450 inhibitor, histamine H2-receptor antagonist. SGTC_1324 1418-0026 34.4 µM 2.44082655570573 0.0130191781750188 no 141 0.00732684537107552 115 1372513 SGTC_1089 terbinafine 2.25 µM 2.44063213350257 0.0130253976808896 no 142 0.00733079062653365 114 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_2875 9039966 71.43 µM 2.43221192966953 0.0132972331411445 no 143 0.00750346182617938 75 6463691 SGTC_630 4356-0227 183 µM 2.42816295056406 0.013429684751985 no 144 0.00758776161639575 88 779312 SGTC_2533 agelasine 13.65 µM 2.42398896138672 0.0135674166569191 no 145 0.00767553604710338 167 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase. SGTC_1007 4101-0031 70 µM 2.4137992632428 0.0139087839536467 no 146 0.00789357867688607 119 1146276 SGTC_2825 7998094 58.44 µM 2.39979638845257 0.0143899625657338 no 147 0.00820209682382329 133 2987815 SGTC_157 1348-1695 65.819 µM 2.3926096649419 0.0146424373342769 no 148 0.00836451394443648 203 5380510 SGTC_1250 0485-0349 40.2 µM 2.38556070100411 0.0148937656986276 no 149 0.00852655393066934 161 6842794 YDL195W SEC31 SGTC_2067 5224629 34.075 µM 2.37683510473851 0.0152100035429427 no 150 0.0087309461190192 138 2835000 SGTC_2271 7849410 118.62 µM 2.36825659824818 0.0155265164078374 no 151 0.00893606790082027 116 972430 SGTC_19 0279-0214 38.434 µM 2.34949073158561 0.0162386620791589 no 152 0.00939955606525338 222 3566274 YBR002C RER2 SGTC_841 0251-0215 91.2 µM 2.34921621279147 0.0162492840614802 no 153 0.00940648946542238 194 3888614 SGTC_1709 st033179 39.1045 µM 2.34617685982042 0.0163672843090473 no 154 0.00948355249271747 137 573381 SGTC_3222 9128301 49.47 µM 2.34597935615879 0.0163749775437301 no 155 0.00948857926132535 130 4911358 SGTC_1812 st052057 4.327 µM 2.33811274112591 0.0166839287573523 no 156 0.0096907002199827 142 3645418 SGTC_2575 plumbagin 510 nM 2.3371017916278 0.0167239918633999 no 157 0.00971694594334824 173 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_569 4130-2812 160 µM 2.33441222967817 0.0168309779738558 no 158 0.00978707351381799 92 743552 SGTC_1001 4048-4355 44.4 µM 2.3342847842197 0.0168360620257119 no 159 0.00979040746616171 150 21824233 SGTC_948 3448-0295 75.3 µM 2.332476016315 0.0169083590789523 no 160 0.00983783159770025 170 678569 SGTC_1824 st053723 68.6 µM 2.32814869131365 0.0170824017191791 no 161 0.00995210478230002 163 675225 SGTC_2698 st077697 67.5 µM 2.3259902117035 0.0171697854306373 no 162 0.0100095364341029 131 3154499 SGTC_1283 0922-0125 16.4 µM 2.32072229507907 0.0173846564022537 no 163 0.0101509183211478 137 3360884 SGTC_1360 1598-0022 39.8 µM 2.31833760676307 0.0174826770710987 no 164 0.0102154900459062 211 761525 SGTC_568 1193-0097 7.48 µM 2.31376045926514 0.0176721394447677 no 165 0.010340432714481 304 3646150 SGTC_1301 naphtanilide LB 4.81 µM 2.30776989787798 0.0179227524467538 no 166 0.0105059690147866 127 67238 An a1-adrenergic receptor antagonist or alpha blocker. SGTC_1387 3342-1166 1.8 µM 2.30333978749569 0.0181100283771018 no 167 0.0106298663411284 90 3418228 SGTC_497 capsazepine 133 µM 2.29732568891255 0.0183669322192268 no 168 0.0108000987027446 122 2733484 A calcium channel blocker. SGTC_2658 polymyxin b sulfate 77.05 µM 2.29603615579727 0.0184224194774112 no 169 0.0108369070865169 175 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides.  YIL048W NEO1 SGTC_2629 bisabolol 100 µM 2.29588352989043 0.0184289962495417 no 170 0.010841270852949 167 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer. SGTC_2414 st077232 92.9 µM 2.28950729738808 0.0187055456119251 no 171 0.0110249472013 155 729801 SGTC_1333 1482-0047 286 µM 2.2762515795504 0.0192917897898123 no 172 0.0114154781845713 168 3811116 SGTC_3165 9101544 49.47 µM 2.26781796937972 0.0196728422262084 no 173 0.0116701518559197 135 5002184 SGTC_1647 st011722 22.4 µM 2.26585764858993 0.0197623242506454 no 174 0.0117300501910408 118 2854783 SGTC_2929 9013348 24.6 µM 2.26411584750519 0.0198421212219621 no 175 0.0117834952647831 165 2995952 SGTC_120 rhodamine 6G 52.259 µM 2.26289226656936 0.0198983403955631 no 176 0.011821165619861 207 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase SGTC_2894 9048625 32.47 µM 2.25857315958749 0.0200978697748699 no 177 0.0119549744853598 142 4092861 SGTC_3273 9137859 49.47 µM 2.2546058636989 0.0202826392528646 no 178 0.0120790395377002 90 2377234 SGTC_832 4083-0019 164 µM 2.24693089986439 0.0206441759552313 no 179 0.0123222217852742 345 1990758 SGTC_896 0964-0007 44.5 µM 2.24348651911453 0.0208081928521095 no 180 0.012432729109764 112 6756758 SGTC_1420 4'-methoxyflavone 42 µM 2.24130961029625 0.0209124223498542 no 181 0.0125030134415939 132 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13 SGTC_1857 st056007 79.3 µM 2.23424572555408 0.02125368681137 no 182 0.0127334546524669 109 619834 SGTC_2174 5790901 200 µM 2.22889167180093 0.0215154747228231 no 183 0.0129105566910797 188 786020 SGTC_2614 arthonioic acid 13.39 µM 2.22613734179469 0.0216512067377637 no 184 0.0130024916887442 151 6710684 SGTC_2968 9090663 33.37 µM 2.22606149342413 0.0216549547206485 no 185 0.0130050313694897 177 25236811 SGTC_1552 6-methylflavone 10.6 µM 2.22224483567546 0.0218442607136196 no 186 0.0131333819713321 115 689013 SGTC_652 0437-0092 114 µM 2.21874388266741 0.0220191349242588 no 187 0.0132520768758149 135 3091274 SGTC_2471 5466956 24.79 µM 2.21232913219533 0.0223426217564245 no 188 0.0134719658022631 112 724419 SGTC_9 0092-0002 10.449 µM 2.21183561451114 0.0223676743821506 no 189 0.0134890126616317 164 759368 SGTC_2606 farnesol 9.78 µM 2.21165199286046 0.0223770016839712 no 190 0.0134953599871122 163 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_531 3788-1495 174 µM 2.21055417262826 0.0224328353648526 no 191 0.0135333626079419 180 2896655 SGTC_1471 k673-0312 37 µM 2.20904229687552 0.0225099196420576 no 192 0.0135858495332445 135 24099884 SGTC_1763 st044482 94.5 µM 2.20836828742386 0.0225443565031346 no 193 0.0136093052943407 172 88505 SGTC_2844 9010103 25.97 µM 2.20382633980685 0.0227775762708691 no 194 0.0137682797131961 200 2480525 SGTC_1629 st005085 44.9 µM 2.20278401192614 0.0228313835663904 no 195 0.0138049877834892 204 24207091 SGTC_3095 9117207 49.47 µM 2.19707587528587 0.0231279530752893 no 196 0.0140075138735223 105 17015229 SGTC_47 0149-0135 24.25 µM 2.19615978745487 0.0231758496929667 no 197 0.0140402542443217 164 5239155 SGTC_1090 efavirenz 20.7 µM 2.18989557970073 0.0235056095461652 no 198 0.0142659053188444 156 64139 A non-nucleoside reverse transcriptase inhibitor. SGTC_2950 9072895 21.46 µM 2.18341256949436 0.0238510350484605 no 199 0.0145027205655777 236 17332245 SGTC_2642 cholecalciferol 100 µM 2.18340257808678 0.023851570682624 no 200 0.0145030881334216 135 9821465 A vitamin D precursor, similar to steriods. SGTC_2194 5927483 104.545 µM 2.17468356911684 0.0243228623790189 no 201 0.0148269185073066 171 760979 SGTC_2285 7945142 200 µM 2.17289759423637 0.0244203590588511 no 202 0.0148940127951989 179 2970608 SGTC_1298 1079-1278 263 µM 2.17237835036843 0.0244487661536964 no 203 0.0149135683089989 169 2840950 SGTC_1901 st060216 58.6 µM 2.17213315695833 0.0244621899759686 no 204 0.0149228103363745 177 688792 SGTC_1807 st050092 58.9 µM 2.16995764746574 0.0245815657237795 no 205 0.0150050272707726 168 5008496 SGTC_2356 9061756 188.97 µM 2.16969692616591 0.0245959049152975 no 206 0.0150149065372917 112 20104043 SGTC_786 4544-0069 423 µM 2.16724399129016 0.0247311558010748 no 207 0.0151081273328271 197 748821 YLR208W SEC13 SGTC_312 4092-0653 6.84 µM 2.16113746762464 0.0250705718335106 no 208 0.0153423610400218 262 1148278 SGTC_2846 9008642 19.48 µM 2.15781512833154 0.0252568702503549 no 209 0.0154711040994838 158 2992898 SGTC_2346 9031566 143.75 µM 2.15611437064877 0.0253526873513583 no 210 0.0155373678215028 156 4771086 SGTC_2391 6285546 200 µM 2.15333675302352 0.0255098271460375 no 211 0.0156461111568977 208 846083 SGTC_3249 9135183 49.47 µM 2.15321819599655 0.0255165524516506 no 212 0.0156507671424755 177 4902779 SGTC_2587 piperic acid 92.2 µM 2.14293277480094 0.0261056845950957 no 213 0.0160592483893775 185 5370536 SGTC_2195 6536160 144.242 µM 2.14082053007829 0.0262280679442157 no 214 0.0161442568550078 146 3834386 SGTC_906 1165-0455 526 µM 2.13749779994862 0.0264215573347368 no 215 0.0162787622348944 136 3252859 SGTC_1567 st069303 68.4 µM 2.13638840118473 0.0264864249479757 no 216 0.016323884338816 197 5581319 SGTC_1560 lithocholic acid 53.1 µM 2.13499659553531 0.0265679933090187 no 217 0.0163806441055125 98 9903 A bile acid which acts as a detergent. SGTC_1416 3966-0321 25.3 µM 2.1285287906075 0.026949804949591 no 218 0.0166466327493766 192 582530 YLR208W SEC13 SGTC_678 1218-2179 85.9 µM 2.12673786681408 0.0270563340314317 no 219 0.0167209346847015 99 6820081 YOR116C RPO31 SGTC_1382 3002-2117 298 µM 2.12605599071584 0.0270969861659124 no 220 0.0167492988780721 168 1497314 SGTC_1373 2887-0003 58.5 µM 2.11806705464467 0.0275770793233899 no 221 0.017084694602614 198 776948 SGTC_860 0443-0016 25.1 µM 2.11796229440437 0.0275834216612805 no 222 0.0170891305566199 187 5337942 SGTC_1772 st048439 82.2 µM 2.11087228925269 0.0280154953516445 no 223 0.0173916452472759 227 2927068 YDL195W SEC31 SGTC_2337 9009472 200 µM 2.10996958397509 0.0280709096739013 no 224 0.0174304879193478 237 5742383 SGTC_1225 1216-0074 20.6 µM 2.10983767808892 0.0280790146113394 no 225 0.0174361699205096 190 4241466 SGTC_2635 hydroquinidine 100 µM 2.10625816702987 0.0282997021447124 no 226 0.0175909664865722 176 442912 An experimental heart treatment. SGTC_677 0929-0063 136 µM 2.10253466720185 0.0285307969535524 no 227 0.0177532330808213 126 1539583 SGTC_2959 9079155 11 µM 2.09589617010494 0.0289467017183053 no 228 0.0180457012716197 181 16189457 SGTC_3104 9120930 49.47 µM 2.09172455805845 0.0292106240682597 no 229 0.0182315811820162 154 17014836 SGTC_1331 1472-0049 76.2 µM 2.09149741003931 0.0292250520719993 no 230 0.0182417491775173 206 24051409 SGTC_646 4092-0839 27.3 µM 2.08181716953341 0.0298454457715126 no 231 0.0186795864274798 182 877796 SGTC_412 gemfibrozil 100 µM 2.0815813500197 0.0298606943963059 no 232 0.0186903631912167 145 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels. SGTC_2088 5278280 127.392 µM 2.06950436911326 0.0306503028517617 no 233 0.0192493908794291 245 791502 SGTC_2244 6635614 200 µM 2.06650050192262 0.0308493622646361 no 234 0.01939062253127 96 836499 SGTC_2433 5607874 27.82 µM 2.06297688067061 0.031084227263497 no 235 0.0195574123964553 217 2252428 SGTC_413 propylparaben 100 µM 2.06160976141078 0.0311757492871739 no 236 0.019622451971018 180 7175 A pharmaceutical preservative. SGTC_40 0327-0103 19.753 µM 2.06045423893365 0.031253279650112 no 237 0.0196775681375407 236 409036 SGTC_2219 9098279 200 µM 2.05900849045234 0.0313505073765254 no 238 0.0197467125705201 163 902349 SGTC_2141 5621638 7.665 µM 2.05460379111286 0.0316482697622226 no 239 0.0199586446004112 178 2856238 SGTC_141 0443-0274 32.331 µM 2.04739261619163 0.0321407956391978 no 240 0.0203097753896625 329 1627241 SGTC_3355 9151058 44.0485 µM 2.04611179632432 0.032228934440804 no 241 0.0203726863287583 190 17015728 SGTC_2016 5121758 140 µM 2.02942779876686 0.033395365519796 no 242 0.02120736803681 275 2795203 SGTC_2418 pentamidine 31.67 µM 2.02712617656906 0.0335589744000651 no 243 0.0213247552331684 236 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_360 0957-0399 1.01 µM 2.02353683030152 0.0338154363491955 no 244 0.0215089151787123 246 6752301 YPR165W RHO1 SGTC_1484 3473-2379 286 µM 2.01975395893289 0.0340874687716635 no 245 0.0217044575088148 221 671917 SGTC_1765 st044815 90.4 µM 2.01917742629683 0.0341290857551059 no 246 0.0217343908400459 221 645695 SGTC_1967 st070177 51.4 µM 2.0105169937504 0.034759280971629 no 247 0.0221882497308271 179 5729214 SGTC_3306 9127676 59.7925 µM 2.01044167284862 0.0347648034908747 no 248 0.0221922318158971 212 41905287 SGTC_2171 5739187 198.077 µM 2.00173186895373 0.0354082804404499 no 249 0.0226567884681943 167 2262761 SGTC_2132 5317594 122.667 µM 1.99682881071359 0.0357747924213222 no 250 0.0229218913411084 177 794577 SGTC_1385 3091-4834 14.1 µM 1.98954529105989 0.0363249818108601 no 251 0.0233205239532721 196 4072814 SGTC_3173 9105693 49.47 µM 1.98918501334295 0.0363523755918655 no 252 0.0233403927361092 241 17096658 SGTC_1025 k007-0731 70 µM 1.98098016178622 0.036980823795346 no 253 0.0237967491833836 212 6256118 SGTC_2807 7945238 51.95 µM 1.97729483999261 0.0372659762474334 no 254 0.0240041563023208 260 17148797 SGTC_2074 5212007 75.395 µM 1.97557454068942 0.0373996983810252 no 255 0.0241014922478364 180 758611 SGTC_919 tnp00227 403.569 nM 1.97333573545031 0.0375743116181635 no 256 0.0242286620417092 262 1269246 A methoxyflavone. YNL221C POP1 SGTC_1971 st069429 63.5 µM 1.96820171320806 0.03797724837052 no 257 0.0245224166183684 184 1246522 YGL099W LSG1 SGTC_868 0527-0199 213 µM 1.96717635870844 0.0380581427641657 no 258 0.0245814412715136 247 2849450 SGTC_78 0336-0123 156.75 µM 1.96586519123118 0.0381617908394838 no 259 0.0246570924422876 197 6765896 SGTC_3029 9088683 49.47 µM 1.96306659948074 0.0383837902687745 no 260 0.0248192179697727 224 25236615 SGTC_286 k060-0067 22.9 µM 1.95763493073569 0.0388176639478302 no 261 0.0251364327503651 234 5985051 SGTC_489 paxilline 115 µM 1.95187196151903 0.039282360353456 no 262 0.025476703955886 210 105008 A toxic potassium channel blocker. SGTC_1444 4112-3581 28 µM 1.9499538961032 0.0394380237478482 no 263 0.0255908071933257 223 2877249 SGTC_44 0929-0055 61.211 µM 1.94267456369514 0.0400333605364421 no 264 0.0260277457211628 216 1379590 SGTC_208 k072-0098 12.366 µM 1.94212152419322 0.04007888749878 no 265 0.026061195188175 312 5948901 SGTC_1378 2093-0007 380 nM 1.93645197938568 0.0405480424109291 no 266 0.0264061842543356 254 3618014 SGTC_492 tmb-8 126 µM 1.92660410658796 0.0413735442248154 no 267 0.0270144932456591 101 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1 SGTC_3054 9094397 49.47 µM 1.92622283285806 0.0414057765265564 no 268 0.0270382779957636 282 2598354 SGTC_802 4112-3352 742 µM 1.92247776370396 0.0417234618275379 no 269 0.0272728344666104 266 704594 SGTC_1744 st037937 38.9 µM 1.91905656478317 0.0420153967170062 no 270 0.0274885878170274 240 1016152 SGTC_959 1222-0044 107 µM 1.91802336837294 0.0421038849262425 no 271 0.0275540240660392 248 6083612 SGTC_734 2023-0417 80 µM 1.91012320663473 0.0427854914841365 no 272 0.0280586758376141 243 3935732 SGTC_2933 9026794 32.47 µM 1.90183311402808 0.0435103020412811 no 273 0.0285964878345109 285 17586027 SGTC_1837 st055472 66.5 µM 1.90108939686821 0.0435758074927813 no 274 0.0286451520942883 258 676091 SGTC_2695 st077686 51.995 µM 1.88829477849957 0.0447152505970877 no 275 0.0294931939559806 247 2876092 SGTC_1189 1431-2119 7.28 µM 1.88756063353164 0.0447813520596771 no 276 0.0295424795844076 309 3107275 SGTC_902 1120-0002 2.07 µM 1.8837817110351 0.0451228472094719 no 277 0.0297972542007023 306 3280475 SGTC_963 1269-2853 151 µM 1.88208849321137 0.0452765389220008 no 278 0.0299120007189841 253 3668223 SGTC_1286 0929-0070 131 µM 1.88055345966763 0.045416236092819 no 279 0.030016343862034 278 1420408 SGTC_879 0831-1030 162 µM 1.88018531405643 0.0454497910165835 no 280 0.0300414132000928 329 1549252 SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM 1.87580109762557 0.045850928334983 no 281 0.0303412986132947 229 688798 SGTC_3046 9092212 49.47 µM 1.87470879398044 0.0459513109613273 no 282 0.0304163982121273 226 25236637 SGTC_3186 9110464 49.47 µM 1.87245716115715 0.0461587929830322 no 283 0.0305716916292951 222 17018021 SGTC_2498 4'-Methoxychalcone 54.63 µM 1.86510822373244 0.0468412181466975 no 284 0.0310831180439466 249 641818 YHR062C RPP1 SGTC_3153 9100258 49.47 µM 1.86329460317262 0.0470108706790419 no 285 0.0312104145153801 279 25236848 SGTC_2058 5236698 133 µM 1.86272298613298 0.0470644437762312 no 286 0.0312506250843992 264 766665 SGTC_1864 st057645 30.4 µM 1.85631534024436 0.0476683369355874 no 287 0.0317043119055433 203 688666 SGTC_1940 st075990 51.1 µM 1.85410692614344 0.0478779027752024 no 288 0.0318619320081902 303 1084979 SGTC_2600 tangeritin 87.95 µM 1.85206449504208 0.048072373672167 no 289 0.0320082810781342 248 68077 A bioactive flavone. SGTC_921 1561-0023 372 µM 1.84615076287905 0.0486390187673496 no 290 0.0324351589214188 268 24050882 SGTC_897 1000-0139 31.4 µM 1.83510667170279 0.0497115354749269 no 291 0.0332449427985722 246 6151020 SGTC_2007 4011539 71.82 µM 1.83379792734196 0.0498398715279372 no 292 0.03334199776375 295 45595301 SGTC_148 3253-0744 288.01 µM 1.83263526697546 0.0499541040668202 no 293 0.0334284149120086 253 6893655 SGTC_1649 st011737 51.3 µM 1.83131533311082 0.0500840418547971 no 294 0.0335267451706992 261 1761035 SGTC_549 1661-1316 519 µM 1.82983424943902 0.0502301643401429 no 295 0.0336373638491726 282 2857282 SGTC_1145 3546-0597 10.2 µM 1.82012971130273 0.0511960315975635 no 296 0.034369626968413 301 875334 SGTC_1037 k284-1091 78.7 µM 1.81404855728146 0.0518087660446453 no 297 0.0348351252083226 237 3334711 SGTC_816 0325-0417 81.3 µM 1.8127983294788 0.0519354578833864 no 298 0.0349314658613133 235 68101 SGTC_3031 9088762 49.47 µM 1.80465304195834 0.0527668973502604 no 299 0.0355644961457041 283 205253 SGTC_629 3448-6466 76.7 µM 1.80056975342465 0.0531876594446837 no 300 0.0358853600502531 303 573744 SGTC_2869 9037858 32.47 µM 1.78601494269544 0.0547091327043625 no 301 0.0370484193678164 231 27187042 SGTC_345 1362-0200 395 µM 1.78526938379413 0.0547879859708622 no 302 0.0371088162020447 268 1419823 SGTC_2081 5214970 32.255 µM 1.78432137433919 0.0548883809251949 no 303 0.0371857294973059 268 2063512 SGTC_2091 4-phenylthiadiazole 200 µM 1.78403470345694 0.0549187682132529 no 304 0.0372090131297389 305 270010 SGTC_2108 5365811 200 µM 1.78352921692308 0.0549723824823609 no 305 0.0372500981608299 304 780283 SGTC_3089 9117425 49.47 µM 1.78263020770848 0.0550678377944625 no 306 0.0373232595780026 298 9401657 SGTC_517 1365-0151 113 µM 1.78237127559217 0.055095355055562 no 307 0.0373443532471283 295 768657 SGTC_657 3534-0529 86.7 µM 1.76940972990339 0.0564867411080916 no 308 0.0384127615294474 295 1049549 SGTC_7 0192-1582 4.227 µM 1.7644351736041 0.0570280424044738 no 309 0.0388293703240677 392 252616 SGTC_814 3342-0569 96 µM 1.76161648199185 0.0573365631805604 no 310 0.0390670586401139 332 4346283 SGTC_3138 9097216 49.47 µM 1.75859171511879 0.0576690992664325 no 311 0.0393234405961869 279 25237486 SGTC_3322 9139058 2.11 µM 1.75257932126597 0.0583345902642447 no 312 0.0398371216766287 299 4908926 YPR165W RHO1 SGTC_1186 1319-0216 26 µM 1.74665837491947 0.0589958395797458 no 313 0.0403483074085549 312 4565136 SGTC_1065 prochlorperazine maleate 2.48 µM 1.7428875921005 0.0594200149336969 no 314 0.0406766259168497 326 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine. SGTC_1879 gemcitabine 100 µM 1.73992285016502 0.0597551945858786 no 315 0.0409362828858174 292 60750 A nucleoside analog which inhibits DNA replication. SGTC_2145 5634607 200 µM 1.73765855692491 0.0600121810806628 no 316 0.0411354976176955 250 308662 SGTC_3004 9076122 71.4286 µM 1.73720165145253 0.0600641424642954 no 317 0.0411757917688821 325 44782551 SGTC_3323 9138564 53.9225 µM 1.73585028381008 0.0602180323802336 no 318 0.0412951551936903 345 43912313 YNL103W MET4 SGTC_1943 st076331 65.2 µM 1.73272637390871 0.0605749557408663 no 319 0.0415721572553919 291 24208415 SGTC_1631 benzylvanillin 81.9 µM 1.72714477122633 0.0612168014911125 no 320 0.0420708333340768 338 75506 SGTC_1419 3993-2473 62.6 µM 1.72169349522505 0.0618487782032673 no 321 0.0425625281474015 297 704026 SGTC_3280 9140961 49.47 µM 1.71875494487861 0.0621915560614539 no 322 0.0428295013123013 265 4901226 SGTC_1990 st072050 59.8 µM 1.71713094009552 0.0623816287807864 no 323 0.04297762507672 291 17233948 SGTC_2070 5230947 200 µM 1.714213827912 0.0627241834326702 no 324 0.0432447311129339 308 2835538 SGTC_1066 ketoconazole 628 nM 1.70485721957487 0.063832821782163 no 325 0.0441105283750883 355 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W SGTC_2842 9000675 19.48 µM 1.70277172553217 0.0640819909825784 no 326 0.0443053980478506 314 2989072 SGTC_2856 9022925 19.48 µM 1.702218755989 0.064148184958287 no 327 0.0443571840245719 335 4944862 SGTC_2146 5545642 200 µM 1.70047642218765 0.0643571010299551 no 328 0.0445206738331675 296 825326 SGTC_1844 rapamycin 4 nM 1.69816212691832 0.0646354157292746 no 329 0.0447385832354407 492 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2 SGTC_2206 7254556 146.969 µM 1.6972989357142 0.0647394612223576 no 330 0.0448200791809609 229 4398905 SGTC_3352 9151559 45.5865 µM 1.69676264323406 0.0648041691720787 no 331 0.0448707720080603 308 17159339 SGTC_3083 9117465 49.47 µM 1.69555543314179 0.0649500124105315 no 332 0.0449850519542899 342 16420915 SGTC_909 3448-9333 149 µM 1.69351278423453 0.0651973652645229 no 333 0.0451789517672991 304 3344074 SGTC_126 0417-1624 672.48 µM 1.69093451370596 0.0655106215779758 no 334 0.0454246553004312 413 41912 YDL195W SEC31 SGTC_119 0121-0043 24.815 µM 1.68880813232532 0.0657698512030098 no 335 0.0456281024377897 530 1092378 SGTC_2661 dactinomycin 12.96 µM 1.68385472926932 0.0663768094553022 no 336 0.0461048735894547 357 45006140 An Actinomycin D Classic transcription inhibitor. SGTC_1149 3909-7961 23.3 µM 1.68299628199669 0.0664824376414444 no 337 0.0461879055887377 323 735261 SGTC_1506 4226-2149 212 µM 1.68188246637299 0.0666196816847103 no 338 0.0462958166451368 389 991114 SGTC_2109 5483026 200 µM 1.68012517868164 0.0668366599477711 no 339 0.0464664814779226 377 759335 SGTC_2621 lithochol-11-enic acid 100 µM 1.67763243635158 0.0671453846569258 no 340 0.0467094382739225 380 6708711 SGTC_1364 1653-0028 37.6 µM 1.67642051626022 0.0672958780907333 no 341 0.046827926536991 343 5718652 SGTC_1908 st060353 56.5 µM 1.67482664390678 0.0674941982854004 no 342 0.0469841248198026 394 4227716 SGTC_2475 5812728 15.03 µM 1.67413461832435 0.0675804452021256 no 343 0.047052072753744 354 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2 SGTC_1034 k072-0165 12.7 µM 1.67340727739794 0.0676711852180298 no 344 0.0471235730955958 370 5835461 SGTC_479 n-linoleoylglycine 10 µM 1.66706869955496 0.0684659486885483 no 345 0.04775037258825 276 6433346 An anti-infammatory. SGTC_2683 piperine 63.03 µM 1.65510292167239 0.069985883282115 no 346 0.0489518111726309 292 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_3354 9151612 71.43 µM 1.65232038922864 0.0703430232180389 no 347 0.0492346274951128 352 27261949 SGTC_1727 st034309 9.9045 µM 1.65198716559985 0.0703858864896474 no 348 0.0492685836199456 436 870305 SGTC_1094 duloxetine 25.4 µM 1.65093809940248 0.0705209612662545 no 349 0.0493756075916887 352 60834 A selective serotonin reuptake inhibitor. SGTC_1460 k062-0059 9.15 µM 1.64435769594048 0.0713727845296491 no 350 0.0500511690276224 320 1373085 SGTC_1682 st012968 530 nM 1.63943370685717 0.0720153366393975 no 351 0.0505614832728609 311 24207270 SGTC_1587 estradiol valerate 56.1 µM 1.63886057909725 0.0720904137407247 no 352 0.0506211496383974 357 13791 A steroid. SGTC_2923 7992654 58.14 µM 1.63760767210515 0.0722547477321692 no 353 0.0507517807979076 356 2985126 SGTC_1366 1683-0113 21.9 µM 1.63535513898767 0.0725509166804412 no 354 0.0509873104503258 329 708623 SGTC_1617 st002906 78 µM 1.63432966495381 0.0726860563278573 no 355 0.0510948240079625 370 5150859 SGTC_317 4495-0002 170 µM 1.63313640650592 0.0728435496046963 no 356 0.0512201555779525 302 15991618 SGTC_533 1222-0222 6.71 µM 1.62798001563629 0.073527125534727 no 357 0.0517645616554825 386 3982874 SGTC_454 lyso-paf C-16 6.67 µM 1.62391988785016 0.0740688145528085 no 358 0.0521964537170424 340 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_1441 4106-0040 13 µM 1.62386706084046 0.0740758825977327 no 359 0.0522020919407262 339 2904180 SGTC_711 k292-0785 179 µM 1.61982610697118 0.0746180748293443 no 360 0.0526348182528621 351 4146315 SGTC_1130 3454-2858 15.9 µM 1.61722060590803 0.0749692688821143 no 361 0.0529153349584466 405 715628 YIL048W NEO1 SGTC_769 0302-0231 76 µM 1.61625166772405 0.0751001926465837 no 362 0.0530199559774683 452 571869 YER009W NTF2 SGTC_1092 toremifene 6.32 µM 1.61550938027504 0.0752006090608617 no 363 0.0531002153169919 425 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_3241 9133421 49.47 µM 1.61542741336816 0.0752117037916715 no 364 0.0531090838375245 247 17018221 SGTC_358 0075-0058 9.45 µM 1.61527829378105 0.0752318912559256 no 365 0.053125221045009 486 1069125 SGTC_1637 st007924 17.4 µM 1.60889256077678 0.0761002586422559 no 366 0.0538199182217714 348 683336 SGTC_1121 fusaric acid 630.51 nM 1.60807273463519 0.0762122935851234 no 367 0.0539096249336927 380 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler. SGTC_3187 9109394 49.47 µM 1.60690040747772 0.0763727182849672 no 368 0.0540381085112707 385 17098090 SGTC_2185 6113692 200 µM 1.60603637434579 0.0764911195001247 no 369 0.0541329590414171 332 874150 SGTC_2200 6600604 21.907 µM 1.60594545424359 0.076503586687114 no 370 0.0541429475888701 404 2904777 SGTC_688 0527-0193 473 µM 1.60578993638652 0.0765249152595923 no 371 0.054160036273081 347 4007154 SGTC_2173 5763948 167 µM 1.60525595355227 0.0765981830252441 no 372 0.0542187441093586 373 2867177 SGTC_1902 st060212 70.5 µM 1.60435647164782 0.0767217215203753 no 373 0.0543177499619769 377 688944 SGTC_2153 5569715 200 µM 1.60366138543818 0.0768172912145024 no 374 0.0543943559355404 337 2054701 SGTC_115 0527-0192 112.043 µM 1.60232102044685 0.0770018379290967 no 375 0.0545423198500835 481 4233931 SGTC_251 melphalan 456.522 µM 1.602214820982 0.0770164742831672 no 376 0.0545540568858489 421 460612 A DNA alkylator. SGTC_2100 5377183 190 µM 1.58914018489765 0.0788346154808714 no 377 0.0560143735561781 397 2844202 SGTC_586 0957-0265 8.15 µM 1.58621378966619 0.0792459743766683 no 378 0.0563454103568904 296 6752309 YPR165W | YPR107C RHO1 | YTH1 SGTC_1771 st048882 4.1505 µM 1.58603466142802 0.0792712068401641 no 379 0.0563657235057428 359 4580403 SGTC_3008 9078912 71.4286 µM 1.58277798918876 0.0797310112012994 no 380 0.0567360376188774 348 16648731 SGTC_460 trequinsin 123 µM 1.58261633871458 0.0797538868199055 no 381 0.0567544685952863 343 5537 A vasodilator. SGTC_2017 5132927 60.65 µM 1.58177746658721 0.0798726777376863 no 382 0.0568501904151846 399 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis SGTC_736 0958-0254 92.6 µM 1.57850056617241 0.0803379952097708 no 383 0.0572253290836037 408 6812352 SGTC_82 0054-0107 293.755 µM 1.57804441668684 0.0804029301920066 no 384 0.0572777030700471 333 3104697 SGTC_1015 4130-4525 82 µM 1.57638885731019 0.0806389398758538 no 385 0.0574681073687471 385 1363237 SGTC_1345 1488-0192 31.4 µM 1.56788130027286 0.0818600009921328 no 386 0.0584544183113868 386 658348 SGTC_1342 1486-1464 234 µM 1.56626754203207 0.0820931824564737 no 387 0.0586429981667004 398 3253938 SGTC_838 0109-0203 71.4 µM 1.56522461460396 0.0822441471792027 no 388 0.0587651259638789 383 759422 SGTC_2675 theaflavin digallate 100 µM 1.56303133755431 0.082562308154661 no 389 0.0590226120458421 394 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative. SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM 1.56082430457594 0.0828833989046551 no 390 0.0592826056025033 471 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_2741 miltefosine 3.04 µM 1.56008381236924 0.0829913398094436 no 391 0.0593700381993329 312 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis. SGTC_3204 9114183 49.47 µM 1.55915543242661 0.0831268182867217 no 392 0.059479798170895 389 17027248 SGTC_1177 0983-0204 23.6 µM 1.55640514387475 0.0835291439901239 no 393 0.0598058913990667 405 766818 SGTC_77 0828-0286 12.516 µM 1.55544749517679 0.0836695764617436 no 394 0.0599197650117074 426 745345 SGTC_785 1270-0111 65.3 µM 1.55356947270551 0.0839454901951707 no 395 0.0601435728875895 406 6741994 SGTC_2407 paclitaxel 400 µM 1.54542906832291 0.0851493584367174 no 396 0.0611212568553589 440 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_3205 9113483 49.47 µM 1.54023568769554 0.0859241287516453 no 397 0.0617514568886113 437 17018033 SGTC_1235 benzylparaben 21.5 µM 1.53849904574471 0.086184381804985 no 398 0.0619633208354081 379 7180 SGTC_2848 9016370 25.97 µM 1.53677821609237 0.0864428463938369 no 399 0.0621738148387456 459 7894410 SGTC_1623 st003709 20.3 µM 1.53568928139176 0.086606700976683 no 400 0.0623073025772261 483 16192618 SGTC_1962 st076595 64.5 µM 1.53177021549793 0.0871983335554117 no 401 0.0627895741930287 420 279619 SGTC_782 0083-0095 30.5 µM 1.52891964360332 0.0876305556079588 no 402 0.0631421829261179 448 3591729 An indicator and reagent. SGTC_981 1488-1094 54.9 µM 1.52760381050238 0.0878306091032721 no 403 0.0633054675588144 353 3449522 SGTC_1876 myriocin 605 nM 1.51719672378694 0.0894248728122013 no 404 0.0646085116237328 398 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1 SGTC_2234 tolnaftate 200 µM 1.51501209451822 0.0897622531791617 no 405 0.0648846706432207 303 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7 SGTC_587 k089-0003 57 µM 1.51410153312655 0.0899031535852811 no 406 0.0650000449475978 255 9659696 SGTC_1613 st002381 52.1 µM 1.51206450234378 0.0902189591049435 no 407 0.0652587271028775 417 551167 SGTC_1348 1493-0373 93.8 µM 1.51085106135218 0.0904074728349189 no 408 0.0654132009225183 390 3010129 SGTC_884 0851-0618 334 µM 1.51031966473386 0.0904901198133298 no 409 0.0654809381611229 446 9642473 SGTC_2162 5663267 200 µM 1.50874783990472 0.0907349106971046 no 410 0.0656816174505264 404 6456493 SGTC_1486 3970-0793 4.53 µM 1.50517140025367 0.0912937243915046 no 411 0.066140008009476 399 2844330 SGTC_2607 solasodine 47.35 µM 1.50496314588028 0.0913263422875018 no 412 0.0661667760324462 445 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity. SGTC_1784 st039334 36.3 µM 1.50453929019069 0.0913927554815258 no 413 0.0662212823386268 421 3496984 SGTC_45 0kpi-0036 14.9 µM 1.50388746267976 0.0914949590268467 no 414 0.0663051728507363 384 2795021 SGTC_2106 5357045 167.29 µM 1.50261606601577 0.0916945518594369 no 415 0.0664690389995391 435 668842 SGTC_2881 9058953 51.95 µM 1.50117606074343 0.0919210034468362 no 416 0.0666550150187826 440 17122249 SGTC_1898 st060199 18.6 µM 1.49834998779636 0.0923666281080901 no 417 0.0670211714661137 395 688866 SGTC_3289 9119912 71.43 µM 1.49686157687232 0.0926019674908339 no 418 0.0672146399021236 419 17014829 SGTC_555 4296-0685 37 µM 1.49162049025462 0.0934341902155006 no 419 0.067899331743302 436 2908540 YHR072W ERG7 SGTC_2499 avocadenofuran 51.48 µM 1.488298327397 0.0939645635778028 no 420 0.0683361179390471 463 6857792 A insecticide and lysyl oxidase inhibitor. SGTC_2517 totarol 10 µM 1.48808028224667 0.0939994513714601 no 421 0.0683648613891462 384 460178 An antibacterial membrane disruptor. YGL001C ERG26 SGTC_908 3448-7491 47.7 µM 1.48660517358293 0.0942357237097621 no 422 0.0685595602999147 555 1203031 SGTC_1732 st034308 51.822 µM 1.48619514417952 0.0943014770220374 no 423 0.0686137557865126 424 830119 SGTC_2056 5235370 200 µM 1.48576000234829 0.0943712944274623 no 424 0.0686713066321461 443 5511916 SGTC_287 k060-0039 29.6 µM 1.48426475221795 0.0946114940632344 no 425 0.0688693487019385 400 5861974 SGTC_922 1866-0035 480 µM 1.48287130048685 0.0948357460294457 no 426 0.069054303919264 504 3156169 SGTC_1816 st051957 91.6 µM 1.4801617485599 0.0952729223486892 no 427 0.0694150429483169 403 674121 SGTC_117 lucigenin 22.078 µM 1.47950536517246 0.0953790503311648 no 428 0.0695026492436977 507 65100 An acridine derivative; a dye stuff and potential carcinogen. SGTC_2497 7-hydroxyflavone 100 µM 1.4784740236903 0.0955459795338859 no 429 0.06964047247135 391 5281894 SGTC_1839 st053978 48 µM 1.4736724370754 0.0963259781671335 no 430 0.0702849037539933 426 3788398 SGTC_2453 5731132 22.18 µM 1.47192915313001 0.0966103225669716 no 431 0.0705200050486114 458 1362040 SGTC_3130 9127414 49.47 µM 1.471768562666 0.0966365472163378 no 432 0.0705416928371123 393 1494646 SGTC_363 0455-0021 3.06 µM 1.46945509234868 0.0970149206019603 no 433 0.0708546968873588 468 4597466 SGTC_1239 0337-0584 35.4 µM 1.468471046647 0.0971761927847698 no 434 0.0709881576610329 512 914301 YML130C ERO1 SGTC_171 k064-0041 9.68 µM 1.46337327003326 0.0980148017611362 no 435 0.0716826343450263 353 53325 SGTC_1305 1181-0477 144 µM 1.46271394818123 0.0981236495213976 no 436 0.0717728339453653 420 6252086 SGTC_895 0964-0006 13.7 µM 1.45974771446701 0.0986144419979396 no 437 0.0721797115559532 429 6738897 SGTC_825 1988-2224 89.6 µM 1.45949488065491 0.0986563587968004 no 438 0.0722144743162495 479 1180859 SGTC_3348 9149464 3.537 µM 1.45747209076394 0.0989921826005343 no 439 0.0724930549626425 436 1951442 SGTC_2201 6605497 169.863 µM 1.45563980433975 0.099297100122789 no 440 0.0727461092113749 406 670741 SGTC_638 3970-0837 4.09 µM 1.44885209303598 0.100432651699886 no 441 0.0736894461681895 448 4118451 YLR208W SEC13 SGTC_1173 0443-0020 122 µM 1.44643801800925 0.100838790604563 no 442 0.0740271924980932 464 5331295 SGTC_87 0100-0052 35.5 µM 1.44576267102573 0.100952623642018 no 443 0.0741218897511322 682 200187 YGR083C | YDR527W GCD2 | RBA50 SGTC_142 0335-0849 62.6745 µM 1.443307066475 0.101367317364338 no 444 0.0744669950239408 587 3889043 YPR107C YTH1 SGTC_2484 5809818 12.04 µM 1.43741493689618 0.102367417431214 no 445 0.0753000635337014 446 2870548 SGTC_60 0986-0278 202 µM 1.43250331346075 0.103206559606823 no 446 0.0759999152583163 336 3110598 SGTC_1849 st056239 19.2 µM 1.42740800319541 0.104082351363576 no 447 0.0767311626593801 482 5393181 SGTC_2805 7950783 58.44 µM 1.4271084892849 0.10413399956123 no 448 0.0767743129555915 527 1178958 YDL195W SEC31 SGTC_2411 st077133 39.94 µM 1.42165276261867 0.105078039075301 no 449 0.0775635397772339 542 1403142 YNL221C POP1 SGTC_1873 rapamycin 2 nM 1.41930994365471 0.105485327617506 no 450 0.0779043371994509 526 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1 SGTC_1257 0669-0121 16 µM 1.41711063809779 0.105868704866585 no 451 0.0782252913852622 534 4307855 SGTC_667 1498-1044 59 µM 1.40772310308817 0.107516438988256 no 452 0.0796065389985304 468 6739982 SGTC_2001 4023502 57.655 µM 1.40441602305512 0.108101289175712 no 453 0.080097501138944 503 108941 YCR052W RSC6 SGTC_2317 5986382 200 µM 1.40281670185311 0.108384945982688 no 454 0.0803357526043392 471 877883 SGTC_2724 maprotiline 69.64 µM 1.40272752048881 0.108400779006666 no 455 0.0803490537313134 451 4011 A tricyclic antidepressant. SGTC_1289 0976-0073 69.1 µM 1.39896044759897 0.109071095746065 no 456 0.0809124220711774 490 3391136 SGTC_2997 9067075 71.4286 µM 1.39714510459485 0.109395181270485 no 457 0.0811849702842928 526 27209819 SGTC_1326 1431-2094 10.8 µM 1.39605357889145 0.109590379415289 no 458 0.0813491806588895 505 616278 SGTC_3002 9075603 71.4286 µM 1.39505647539061 0.109768910448289 no 459 0.0814994049071339 503 20105405 SGTC_942 3253-1115 227 µM 1.39501480639449 0.109776375809305 no 460 0.0815056873355824 484 46497897 SGTC_1470 k295-0292 231 µM 1.38578704757425 0.111438595894033 no 461 0.0829059692912389 510 5045612 SGTC_3164 9100705 49.47 µM 1.37981952240642 0.112523087884718 no 462 0.0838211100914368 413 17174235 SGTC_2401 5128683 200 µM 1.37460670276446 0.113476576876074 no 463 0.0846267047328963 456 708373 SGTC_2562 3',7'-dimethoxyflavone 64.92 µM 1.37453222936716 0.113490240596616 no 464 0.0846382558579195 579 688664 SGTC_98 0074-0023 107.663 µM 1.37357476014411 0.113666013094365 no 465 0.0847868685552503 534 3563821 SGTC_3150 9097574 49.47 µM 1.37125351663368 0.114092953030804 no 466 0.0851479702777683 456 17217476 SGTC_2147 5545932 89.7195 µM 1.37025665028132 0.114276654105554 no 467 0.0853033999662041 474 797404 SGTC_491 tetrandrine 80.3 µM 1.37020716947459 0.114285777839843 no 468 0.0853111204619277 436 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_212 3807-4682 38.772 µM 1.36839275472837 0.114620694919083 no 469 0.0855945854550636 662 3125501 YBL034C STU1 SGTC_1080 nisoldipine 24.4 µM 1.36241684717 0.115728705698737 no 470 0.0865331849596583 544 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class. SGTC_1297 1068-0111 14.1 µM 1.35933282265557 0.116303490639419 no 471 0.0870205738415345 480 767057 SGTC_2821 7996764 71.43 µM 1.3541221490888 0.117279226403695 no 472 0.0878487054525579 528 2987135 SGTC_969 1313-0238 134 µM 1.34960623068089 0.11812954251858 no 473 0.0885711622583299 562 5212874 SGTC_599 1935-0052 86.5 µM 1.34918458138898 0.118209158139727 no 474 0.0886388429813825 531 9557311 SGTC_319 1348-1596 45.5 µM 1.34553600571058 0.118899665386047 no 475 0.0892261009448579 543 5380505 SGTC_1477 0139-0234 16 µM 1.34418654103458 0.119155777098165 no 476 0.0894440363827225 502 620880 SGTC_105 0111-0055 734.78 µM 1.34397123604666 0.119196675319277 no 477 0.0894788442353105 417 5179370 SGTC_636 0kpi-0074 126 µM 1.34274958830331 0.1194289208168 no 478 0.089676535936816 478 616434 SGTC_209 4077-0173 175.592 µM 1.34118810093823 0.119726237291362 no 479 0.0899296943529138 401 15993494 SGTC_276 colchicine 750 µM 1.3390104877122 0.120141738731621 no 480 0.0902836293493094 549 2833 A microtubule depolymerizer. SGTC_521 r062-0005 13.8 µM 1.33818734428444 0.120299063682915 no 481 0.0904176867967061 495 2832033 SGTC_824 1304-0008 100 µM 1.33734665181154 0.120459892479897 no 482 0.0905547547954987 565 768245 SGTC_2423 st077119 87.2 µM 1.33258841971262 0.121373020740699 no 483 0.0913334537456018 524 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae). SGTC_781 4335-2806 94.4 µM 1.32782629555455 0.122291757774932 no 484 0.0921177489503025 595 845254 SGTC_1572 epiandrosterone 68.9 µM 1.32707327998909 0.122437479781458 no 485 0.0922422215879874 564 441302 A steroid. SGTC_3075 9116269 49.47 µM 1.32502922926394 0.122833654415888 no 486 0.0925807284627045 536 17015205 YNL244C SUI1 SGTC_347 4534-1311 26.2 µM 1.32390462555626 0.123052006255662 no 487 0.0927673609133942 517 2862016 SGTC_1881 5652484 16 µM 1.32271360927959 0.123283549195169 no 488 0.0929653179928398 529 2255129 SGTC_2660 2',4'-dihydroxychalcone 17.14 µM 1.32110344230768 0.123597063420489 no 489 0.0932334377227436 515 5357218 A potent inhibitor of glutathione S-transferases. SGTC_3148 9097893 49.47 µM 1.32091806739731 0.123633193417665 no 490 0.0932643423857106 500 17174100 SGTC_505 gw-5074 63.9 µM 1.31628414008111 0.124538760476762 no 491 0.0940393460150144 551 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases. SGTC_348 k064-0012 10.7 µM 1.31610041517093 0.12457475951862 no 492 0.0940701708284766 495 5066323 SGTC_1151 3909-8316 15.3 µM 1.31584932533168 0.124623969801628 no 493 0.0941123099827846 535 800431 SGTC_594 1487-1584 10.8 µM 1.31491555520041 0.124807095601285 no 494 0.094269142161311 545 5013332 SGTC_2395 5646831 180.19 µM 1.31350144255305 0.125084781356507 no 495 0.0945070175708205 538 6808628 SGTC_1597 7-benzyloxygramine 47.5 µM 1.31285726330568 0.12521142016804 no 496 0.0946155249839737 684 260807 SGTC_596 1155-0152 116 µM 1.31017878282045 0.125738940927084 no 497 0.095067680801389 604 280313 SGTC_2351 9026858 72.31 µM 1.30874641698801 0.126021677534257 no 498 0.0953101314459535 489 1409300 SGTC_1103 duloxetine 36.1 µM 1.30809618624742 0.126150173627427 no 499 0.0954203434271939 607 60835 A selective serotonin reuptake inhibitor. SGTC_1234 0326-0494 15.5 µM 1.30723844354767 0.126319817093553 no 500 0.0955658714633065 523 1547813 SGTC_3030 9087619 49.47 µM 1.30481218088698 0.126800541431028 no 501 0.095978405177781 520 25236973 SGTC_264 promethazine 12.5 mM 1.29830466886579 0.128096183259331 no 502 0.0970913313411752 679 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3 SGTC_1522 st012842 45.6 µM 1.29647411557942 0.128462296773397 no 503 0.0974060960762752 511 3491067 YOR116C RPO31 SGTC_3074 9116018 49.47 µM 1.29453885508506 0.128850141065463 no 504 0.0977396785941607 493 17027303 SGTC_2432 5630864 12.22 µM 1.29165537351267 0.12942952313188 no 505 0.0982382592375724 544 5714970 SGTC_696 1560-0013 611 µM 1.29122063288468 0.129517032543678 no 506 0.0983135912374535 562 1650269 SGTC_2714 st079313 56.9 µM 1.29079065394257 0.129603623782249 no 507 0.0983881397375755 525 2939799 SGTC_133 0724-0033 378.92 µM 1.29064840869781 0.129632278643119 no 508 0.0984128109150114 518 280309 SGTC_1984 st072354 53.1 µM 1.28998322403334 0.129766336260175 no 509 0.0985282414267688 540 5762938 SGTC_999 SEC7.066 22.7 µM 1.28789614622624 0.130187577340296 no 510 0.0988910585879098 586 740511 YDR170C SEC7 SGTC_984 1492-0255 2.91 µM 1.28642257779506 0.130485561279886 no 511 0.0991478114912946 510 1585198 SGTC_2776 terbinafine 19.92 µM 1.28602064776651 0.130566921090481 no 512 0.0992179278737336 535 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_2581 avocatin a 64 µM 1.2836789709134 0.13104162740945 no 513 0.0996271526804952 599 6710728 A skin care supplement. SGTC_681 1642-0006 26.6 µM 1.28027953099868 0.131732883918832 no 514 0.100223421940015 502 4446530 SGTC_190 3970-0790 3.722 µM 1.28017740827405 0.131753688841276 no 515 0.100241374707357 515 2832352 SGTC_1170 0310-0127 64.8 µM 1.27983710762782 0.131823032855491 no 516 0.100301215145776 574 774975 SGTC_2987 9018338 71.43 µM 1.2790689188647 0.131979661387064 no 517 0.100436393758904 567 5055682 SGTC_614 0462-0418 107 µM 1.27697754977196 0.132406727706737 no 518 0.100805086673309 503 5188303 SGTC_1180 1193-0155 285 µM 1.27680504057448 0.132441997276121 no 519 0.100835542774194 530 2921347 SGTC_2065 5221596 34.26 µM 1.2751319979198 0.132784387330834 no 520 0.101131262728324 563 788581 SGTC_2166 5933061 31.504 µM 1.27431987718586 0.132950808325328 no 521 0.101275037414127 556 2877375 SGTC_1108 betulinic acid 729.144 nM 1.27429630563388 0.132955640786462 no 522 0.10127921265258 574 64945 Apoptosis-inducing agent of unknown mechanism. SGTC_2794 7785382 27.27 µM 1.27385094544228 0.133046967888273 no 523 0.101358123053592 676 2205081 SGTC_2440 5628896 157.78 µM 1.27301620875996 0.133218258173137 no 524 0.101506145106943 552 5522048 SGTC_637 1181-0519 7.26 µM 1.27220156514358 0.133385571559753 no 525 0.101650755839803 670 6252091 YGR060W ERG25 SGTC_1440 4100-1550 40 µM 1.26930080107382 0.133982510651311 no 526 0.102166900384308 516 742806 SGTC_3310 9130229 44.1445 µM 1.26628515181708 0.134605035103614 no 527 0.102705505462874 560 7761258 SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM 1.26430683635697 0.135014498104198 no 528 0.103059958397739 627 4174840 SGTC_3143 9086658 49.47 µM 1.26379674215846 0.135120213534942 no 529 0.103151495412367 649 25236626 SGTC_375 3970-0961 9.27 µM 1.25888697835868 0.136140649214153 no 530 0.104035578925322 577 2898222 SGTC_1109 tnp00067 928.257 nM 1.25724294435961 0.136483517744045 no 531 0.104332838594858 591 676295 SGTC_2286 7945697 125 µM 1.25695779296659 0.136543047028096 no 532 0.104384459722707 572 1245733 SGTC_260 nsc-65238 3.989 µM 1.25673291229283 0.136590006490995 no 533 0.10442518305774 551 3246252 SGTC_2567 aureobasidin a 60 nM 1.25657898126032 0.136622156653986 no 534 0.1044530648549 590 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1 SGTC_2788 5282734 71.43 µM 1.2563008036829 0.136680270177813 no 535 0.104503465327118 641 743706 SGTC_2041 5107442 45.335 µM 1.25155589276383 0.137674123204128 no 536 0.105365867560331 585 793005 SGTC_2305 7443522 69.23 µM 1.24742884399674 0.138542562014254 no 537 0.106120147914989 607 5415886 SGTC_3026 9090633 49.47 µM 1.24662286700985 0.138712595312186 no 538 0.10626790652511 586 25236842 SGTC_2858 9025781 8.96 µM 1.24598053942186 0.138848205982126 no 539 0.106385769879972 715 4894980 YPL153C RAD53 SGTC_1721 st082152 9.2685 µM 1.24586740101084 0.138872101546917 no 540 0.106406539890458 548 5296051 SGTC_2522 biochanin a 4.94 µM 1.24186424384252 0.139719396989507 no 541 0.107143327273592 543 5280373 A possible chelator. SGTC_1191 1487-1166 10.6 µM 1.24106849015622 0.139888241550713 no 542 0.107290224295421 682 3955771 SGTC_726 3448-4391 34.2 µM 1.24067192014965 0.139972438299958 no 543 0.107363485750876 632 1356692 SGTC_2367 9070478 135.38 µM 1.23946635030596 0.140228607226597 no 544 0.107586421453928 613 572802 SGTC_416 estradiol valerate 100 µM 1.23715252869698 0.140721157784769 no 545 0.108015230739595 577 13791 A steroid. SGTC_2864 9034755 47.6 µM 1.23688306359393 0.140778595908744 no 546 0.108065249285193 579 4930451 SGTC_1850 st056238 17 µM 1.23622657538025 0.140918596939808 no 547 0.108187177480184 656 5393177 SGTC_207 4185-0010 4.486 µM 1.23413369909035 0.141365548812878 no 548 0.108576544031456 675 3761753 SGTC_487 nimodipine 119 µM 1.232428062376 0.141730512181775 no 549 0.108894611785801 475 4497 L-type voltage-gated calcium channels inhibitor SGTC_936 3005-4620 401 µM 1.23127584230404 0.141977419172492 no 550 0.109109856962871 655 777207 SGTC_1157 4092-0394 27.6 µM 1.22971654054783 0.14231202235026 no 551 0.109401635327318 659 3659885 SGTC_250 brefeldin a 552.239 µM 1.22859506316702 0.14255300446457 no 552 0.109611833693559 503 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.  SGTC_12 0849-0099 9.267 µM 1.22738099114062 0.142814194148824 no 553 0.109839713767766 575 6071388 SGTC_3109 9122853 49.47 µM 1.2229643121953 0.143767105095133 no 554 0.110671587931326 635 1234709 SGTC_1922 5578187 25 µM 1.22295993549279 0.143768051503788 no 555 0.110672414509217 577 1350412 SGTC_178 4092-0806 87.505 µM 1.22209075070967 0.143956085450127 no 556 0.110836655222654 688 2169044 SGTC_1789 tunicamycin 25 nM 1.21763853093078 0.144921850754506 no 557 0.111680682722185 595 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_1926 methyl fluorone black 53.6 µM 1.21447645513388 0.145610404258551 no 558 0.112282917726505 541 72721 Reacts with homocysteine. SGTC_3324 9138759 60.749 µM 1.21367791031458 0.145784637619824 no 559 0.112435371415625 598 45595710 SGTC_1394 3474-0001 65.7 µM 1.2116626208029 0.146224973647054 no 560 0.112820776559315 544 5017666 YIL048W NEO1 SGTC_3283 9109332 35.8195 µM 1.21027627742863 0.146528404478088 no 561 0.113086448673408 510 17027281 SGTC_800 3448-7362 155 µM 1.20729978807184 0.147181299553533 no 562 0.113658356136118 862 15991913 SGTC_932 2857-0803 154 µM 1.20622340858596 0.147417883580152 no 563 0.113865680195169 659 674898 SGTC_2665 lovastatin 100 µM 1.20371475717584 0.147970263964591 no 564 0.114349923240713 599 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1 SGTC_136 0097-0015 404.482 µM 1.20303840746767 0.148119426334379 no 565 0.114480729087463 666 4861337 SGTC_1105 epirubicin 18.1 µM 1.20154900684615 0.148448253848247 no 566 0.114769154200698 603 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_1292 0kpi-0043 232 µM 1.20113651855103 0.148539408621093 no 567 0.114849124642033 595 3333905 SGTC_423 5-fluorouracil 457 µM 1.20086887467366 0.148598574599026 no 568 0.11490103482687 603 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_1042 0350-0096 82 µM 1.19955791594106 0.148888605757422 no 569 0.115155539553152 600 3122515 SGTC_1650 st011916 45.8 µM 1.19824303189418 0.14917988504142 no 570 0.115411208668061 597 242528 SGTC_459 nigericin 15.3 µM 1.19532777566942 0.149827042662071 no 571 0.11597949588933 656 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification. SGTC_1534 6-azauridine 81.6 µM 1.19498318807335 0.149903661214587 no 572 0.116046799338386 684 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1 SGTC_1780 st038448 24.544 µM 1.19066493265336 0.150866034351682 no 573 0.116892574821112 615 728868 YDL195W SEC31 SGTC_833 3852-0053 558 µM 1.18779643845349 0.151507579899594 no 574 0.11745680895656 706 3123681 SGTC_2792 7535235 81.82 µM 1.1870165001403 0.151682328127921 no 575 0.117610556087573 584 1281891 SGTC_835 0312-0010 67.2 µM 1.18686297172566 0.151716742543127 no 576 0.117640837502644 599 1626196 SGTC_1135 dihydrocapsaicin 536.708 nM 1.17786456136544 0.153742861695992 no 577 0.119425302602503 624 107982 A Capsaicinoid. SGTC_1847 st056231 15 µM 1.17749678376941 0.153826051269864 no 578 0.119498640242454 689 5393180 SGTC_2236 dapsone 200 µM 1.17553134628215 0.154271129016194 no 579 0.119891101959148 661 2955 A bacterial DFR inhibitor. An anti-cancer agent. SGTC_923 1900-2434 73.3 µM 1.17524080239071 0.154336995514148 no 580 0.119949195234264 629 5910570 SGTC_2578 7,8-dihydroxyflavone 64.44 µM 1.17473862103047 0.154450884209509 no 581 0.120049651492296 613 1880 Intensifies effect of antibiotics on Staphylococcus aureus. SGTC_735 3076-0345 636 µM 1.17451145469726 0.154502421048718 no 582 0.120095113272272 701 2888990 SGTC_2029 5175081 200 µM 1.17365430106076 0.154696984389398 no 583 0.120266760840249 685 1380876 SGTC_3100 9120536 49.47 µM 1.17231198452296 0.155001998889772 no 584 0.120535910862665 505 16421196 SGTC_2803 7707263 71.43 µM 1.17136768837431 0.155216809045677 no 585 0.120725507150984 607 2199229 SGTC_2996 9066192 71.4286 µM 1.17041599710643 0.155433500185282 no 586 0.1209168005387 625 6472854 SGTC_191 3914-0123 66.505 µM 1.16878874493883 0.155804472390093 no 587 0.12124437806178 497 3144412 SGTC_516 3992-2719 87.3 µM 1.16702547922296 0.156207110710927 no 588 0.121600040079613 591 5350887 YDR037W KRS1 SGTC_1674 st016616 23.6 µM 1.16686956852759 0.156242745574999 no 589 0.121631523516145 643 625830 SGTC_1800 st050079 29.0735 µM 1.16577949367431 0.156492042098068 no 590 0.12185180510435 788 3645560 SGTC_1947 st076332 61.6 µM 1.1654973395963 0.156556612452498 no 591 0.121908868240493 596 24208416 SGTC_124 0136-0217 7.121 µM 1.16531192359613 0.156599054055161 no 592 0.121946377185569 745 3976905 SGTC_1485 3909-9022 254 µM 1.16253087343222 0.157236543382699 no 593 0.122509945727576 671 714516 SGTC_277 nystatin 15.5 µM 1.15505020364944 0.158959764331892 no 594 0.124034934184964 677 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_1668 st014914 51.6 µM 1.15480800039644 0.159015763478084 no 595 0.124084530082252 638 2839556 SGTC_1933 st074711 15.9 µM 1.15316177830876 0.159396724403015 no 596 0.124421994217807 698 17250958 SGTC_2398 5228213 48.84 µM 1.15145795216148 0.159791644554381 no 597 0.124771942076993 755 80771 YMR134W ERG29 SGTC_181 1447-1644 8.07 µM 1.14870088472799 0.160432044302993 no 598 0.125339670459404 660 534600 SGTC_2915 7971052 15.16 µM 1.14628028853285 0.160995670508587 no 599 0.125839598101106 498 5741558 SGTC_1515 3460-0031 42.1 µM 1.1461845496461 0.161017989464244 no 600 0.125859399679348 574 2876596 SGTC_1734 st037168 69.4 µM 1.1447902574302 0.161343260162536 no 601 0.126148026042226 654 708907 SGTC_1851 st056236 18.9 µM 1.14411522751713 0.161500889941092 no 602 0.126287926679706 689 5393171 SGTC_166 k072-0058 166.424 µM 1.14266232658549 0.161840504989909 no 603 0.12658940859303 670 5846229 SGTC_3013 9080133 71.4286 µM 1.13989486921738 0.162488683491535 no 604 0.127165051436125 728 17050193 SGTC_1206 3978-0017 132 µM 1.13865285228574 0.162780130245345 no 605 0.127423987433302 621 3873677 SGTC_273 hydroxyurea 18.1 mM 1.13840748959745 0.162837746268946 no 606 0.127475184050971 736 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12 SGTC_2299 7976368 114.88 µM 1.13804275622374 0.162923417401507 no 607 0.12755131461826 657 2979718 SGTC_2307 7538926 6.34 µM 1.13685515665455 0.163202572134902 no 608 0.127799420550214 688 96582 SGTC_3251 9135047 49.47 µM 1.13528101054419 0.163573066442937 no 609 0.12812879801537 626 17682963 SGTC_282 k297-0036 65.7 µM 1.13474517520881 0.163699306260194 no 610 0.128241051662082 626 5061378 SGTC_3098 9119039 49.47 µM 1.1331602297687 0.16407308068268 no 611 0.128573486011103 671 17161528 SGTC_2258 7960471 200 µM 1.13101247697598 0.164580463492749 no 612 0.129024919985924 572 2974708 SGTC_560 2332-1943 155 µM 1.13004649274929 0.164808997715169 no 613 0.129228317146789 678 21177716 SGTC_2907 7721985 69.9 µM 1.12906266607787 0.165041964314039 no 614 0.129435699548153 649 3267881 SGTC_2280 7785178 200 µM 1.12821276668327 0.165243388980925 no 615 0.129615036762176 648 2954328 SGTC_974 1326-0144 138 µM 1.12669277729848 0.165604020321034 no 616 0.129936198626571 711 5411856 SGTC_354 2783-3500 4.88 µM 1.12600099234244 0.165768321025833 no 617 0.130082549644688 666 6740761 SGTC_1516 st013856 110 µM 1.12099069248394 0.166961424321117 no 618 0.131145912139596 658 5281404 A mutagen and neurotoxin. SGTC_2154 5570129 200 µM 1.12030850210972 0.167124301726771 no 619 0.131291160117155 709 673366 SGTC_2383 9036125 200 µM 1.11855839391876 0.167542619831799 no 620 0.13166429081896 643 79580 SGTC_894 0960-0238 55.9 µM 1.11487970535791 0.168424112160848 no 621 0.132450987282885 698 6741907 YDL195W SEC31 SGTC_1481 3346-2004 36 µM 1.11252104073297 0.16899086479681 no 622 0.132957094310035 721 2770522 SGTC_2725 haloperidol 53.21 µM 1.11242493331207 0.169013983949643 no 623 0.132977744611685 690 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_1761 st044296 37 µM 1.10824261770382 0.170022029690201 no 624 0.133878524954633 681 1826700 SGTC_2043 5101342 149 µM 1.10550782461464 0.170683264715056 no 625 0.134469802908762 691 678451 SGTC_409 arachidonic acid 100 µM 1.10528077791874 0.170738235363493 no 626 0.13451897218156 699 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes. SGTC_2974 9094440 9.66 µM 1.10450236368679 0.170926784519256 no 627 0.134687639390397 718 25236134 SGTC_3307 9126885 69.2785 µM 1.10378161939077 0.171101483471543 no 628 0.134843939998078 716 24824909 SGTC_2573 2',4'-dihydroxychalcone 15.04 µM 1.10334523555172 0.171207312666352 no 629 0.134938634654302 778 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_2733 amorolfine 100 µM 1.10236013983003 0.171446366030468 no 630 0.135152566666814 604 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_687 k029-0044 34.9 µM 1.10133156159388 0.171696198850882 no 631 0.135376189781539 742 5829338 SGTC_635 k038-0028 24.7 µM 1.09999225577539 0.172021853097149 no 632 0.135667748049758 723 4035102 SGTC_1825 st052143 62.6 µM 1.09916029109569 0.172224344984424 no 633 0.135849077849254 674 674173 SGTC_1280 0880-0253 10.1 µM 1.09815215183248 0.172469919736511 no 634 0.13606902786648 720 6836607 SGTC_2281 7943571 200 µM 1.09814734173953 0.172471091972183 no 635 0.136070077888822 760 1244024 SGTC_3254 9136651 49.47 µM 1.0960419501757 0.172984670745866 no 636 0.136530208284507 748 16454030 SGTC_3266 9136860 49.47 µM 1.09330337269542 0.173654162100869 no 637 0.137130311284841 707 4871271 YPR165W RHO1 SGTC_1605 st000082 49.1 µM 1.09215937677792 0.173934318666159 no 638 0.13738152729117 730 1114022 SGTC_175 3793-3120 23.7 µM 1.09049942879702 0.174341339016998 no 639 0.137746602396368 662 5322297 SGTC_2732 terfenadine 20 µM 1.08747109766632 0.175085445429837 no 640 0.138414332496971 667 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.  SGTC_2090 5301565 104.445 µM 1.08670065541164 0.17527507566927 no 641 0.138584562133136 783 2056344 SGTC_2069 5228469 200 µM 1.08524951354489 0.175632601161292 no 642 0.138905579928958 678 2835210 SGTC_62 0180-0423 3.232 µM 1.08210855369815 0.176408037328703 no 643 0.139602147727589 701 30102 YGL099W LSG1 SGTC_1576 erythromycin ethylsuccinate 23.2 µM 1.08136282283043 0.176592460098252 no 644 0.139767876108571 740 3256 An antibiotic and ribosome inhibitor. SGTC_1638 st008370 60.6 µM 1.08045866540071 0.176816225973633 no 645 0.139968991925815 708 24207134 SGTC_1425 4048-4433 7.33 µM 1.07768487831349 0.177503815812058 no 646 0.140587204531248 775 23734946 SGTC_1511 0906-3109 28.5 µM 1.07714900186522 0.177636847673224 no 647 0.140706852216104 815 2882180 SGTC_966 1300-0360 30.2 µM 1.0707593863938 0.179227920753739 no 648 0.142138816335772 721 70588 SGTC_1018 4259-0013 28.1 µM 1.07054553874454 0.179281325332259 no 649 0.142186911275165 699 6801262 SGTC_1929 genistein trimethyl ether 50.5 µM 1.06977010231177 0.179475060463227 no 650 0.142361401478708 734 136420 SGTC_839 0122-0028 230 µM 1.06687534430109 0.180199449176384 no 651 0.143014064920522 776 759448 SGTC_1365 1672-3266 55.4 µM 1.0660019864071 0.180418359453296 no 652 0.143211371979104 786 6415873 SGTC_2230 bromochlorosalicylanilide 954.5 nM 1.06361492365543 0.181017535986587 no 653 0.143751589508431 671 77254 SGTC_2149 5554786 194.827 µM 1.0634702514178 0.181053890188106 no 654 0.143784374498894 768 745063 YPR165W RHO1 SGTC_1060 3448-7350 82 µM 1.06205168152428 0.181410600153711 no 655 0.144106111861164 748 570178 SGTC_1670 st016595 4.04 µM 1.05781994268464 0.18247731398763 no 656 0.145068769522563 760 597879 SGTC_1570 verbenone 133 µM 1.05622565632515 0.182880207115177 no 657 0.145432565922918 781 29025 A natural terpanoid with antifungal properties. SGTC_1848 st056003 16.4 µM 1.05589726822607 0.182963263186153 no 658 0.145507576167532 776 146492 SGTC_68 0986-0284 82.829 µM 1.05586110296572 0.182972411559279 no 659 0.145515838608319 624 423278 YIL048W NEO1 SGTC_1600 coumarin 106 71.1 µM 1.05088327859194 0.184234325742056 no 660 0.146656100558232 770 100336 A hepatotoxic, DNA x-linker. SGTC_953 1188-0045 9.7 µM 1.05075443926424 0.184267059179597 no 661 0.146685692954222 760 6144426 SGTC_2264 7948757 110.76 µM 1.04794262445547 0.18498234130602 no 662 0.147332521152103 714 2971411 SGTC_55 0767-0285 6.563 µM 1.04685126789758 0.185260429628078 no 663 0.147584090336839 782 3116166 SGTC_2172 5754775 163.918 µM 1.04371638081614 0.186060672319749 no 664 0.148308314383862 681 2263357 SGTC_2449 5812982 45.77 µM 1.04011383517216 0.186982935978074 no 665 0.149143508326758 717 776185 SGTC_3020 9089140 49.47 µM 1.04004400504553 0.187000840619879 no 666 0.149159728324622 736 17217859 SGTC_151 3013-0144 2.285 µM 1.03336300369756 0.1887187709028 no 667 0.150717026539988 772 906558 YHR107C CDC12 SGTC_2347 9049783 174.81 µM 1.03271704878842 0.188885383755638 no 668 0.150868166352836 804 6467988 YPL169C MEX67 SGTC_975 1335-0046 28.5 µM 1.03154102842402 0.189188950410445 no 669 0.151143589254142 757 16486740 SGTC_145 3737-0113 38.366 µM 1.03146655068596 0.189208185491429 no 670 0.151161043129292 862 6849351 SGTC_811 0416-0114 265 µM 1.03087659832228 0.189360592778409 no 671 0.151299345980393 742 6612453 SGTC_3163 9099914 49.47 µM 1.02894652824266 0.189859731562803 no 672 0.151752401262709 728 16268368 SGTC_2656 pseudo-anisatin 100 µM 1.02767682139696 0.190188533376403 no 673 0.152050937207314 772 6708809 A neurotoxin. SGTC_1937 st074714 47.2 µM 1.02710611372368 0.190336437075437 no 674 0.15218525008368 748 17250970 SGTC_3112 9123419 49.47 µM 1.02709423993322 0.190339515018244 no 675 0.15218804535051 809 17015854 SGTC_1806 st050005 60.3 µM 1.02502814060191 0.190875557965407 no 676 0.152674954921832 745 5194765 SGTC_1865 st057639 52.2 µM 1.0246797202739 0.190966045695109 no 677 0.152757167496571 776 688818 SGTC_368 fentichlor 4.58 µM 1.02446222558697 0.19102254425628 no 678 0.15280850199704 682 7329 A pesticide. SGTC_1074 carmofur 3.8 µM 1.02330202372658 0.191324102883325 no 679 0.153082533603958 845 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_438 sphingosine 6.67 µM 1.02247268307626 0.191539843087135 no 680 0.153278617613426 676 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes. SGTC_595 3909-8003 73.7 µM 1.02190574718323 0.191687408458124 no 681 0.153412756040625 769 699517 SGTC_125 0133-0007 11.75 µM 1.02092102887001 0.191943882099457 no 682 0.153645927588066 852 26541 SGTC_3268 9137683 49.47 µM 1.01781143980395 0.192755164337473 no 683 0.154383787205362 760 1953228 SGTC_598 3937-0236 20.2 µM 1.01491900460957 0.193511669488605 no 684 0.155072219103538 847 1379313 SGTC_426 0988-0037 14.6 µM 1.01372543842399 0.193824369208433 no 685 0.155356891087295 846 5383008 SGTC_982 1491-0518 27.5 µM 1.01353299821362 0.193874815004427 no 686 0.155402821380438 736 3091256 SGTC_2378 9074213 121.43 µM 1.01274110050916 0.194082485294018 no 687 0.155591920316539 790 657714 SGTC_1048 3161-0300 24.5 µM 1.0116747802611 0.194362335205564 no 688 0.15584678888401 808 2165101 SGTC_2870 9038528 12.99 µM 1.01163306077509 0.194373289247995 no 689 0.155856766138482 696 6463316 SGTC_160 3453-0671 289.699 µM 1.0112524059379 0.194473252930293 no 690 0.155947819551528 858 5322268 SGTC_1393 3470-5649 58.2 µM 1.0110588743785 0.194524088207186 no 691 0.155994126137628 669 4108395 SGTC_3132 9126706 49.47 µM 1.01022429858651 0.194743400328332 no 692 0.156193920134778 760 850858 SGTC_1870 st057514 26.5 µM 1.01007806080033 0.194781844577171 no 693 0.156228946207994 769 5393161 SGTC_1478 0453-0656 35.7 µM 1.00957593176445 0.194913883717915 no 694 0.15634925278775 810 5258496 SGTC_1776 st049249 45.9 µM 1.0087289540339 0.195136727081507 no 695 0.156552320918664 803 1822314 SGTC_43 0570-0105 72.5 µM 1.00624248660113 0.195791821035362 no 696 0.1571494695301 879 1114046 YDL195W SEC31 SGTC_2277 7947813 106.88 µM 1.00613044806014 0.195821370518067 no 697 0.157176411863753 754 1246798 SGTC_883 0850-0245 24.6 µM 1.00420676647627 0.196329151890772 no 698 0.157639480656946 831 6823229 YPR165W RHO1 SGTC_2924 9010168 62.78 µM 1.00231210795229 0.19683005166018 no 699 0.158096438263273 779 2993929 SGTC_534 k292-0788 63.4 µM 1.00200156107571 0.19691222614591 no 700 0.158171419444687 894 4146317 SGTC_2700 st077718 96.8 µM 1.00176792526217 0.196974062716353 no 701 0.158227845921653 741 904970 SGTC_2355 9061122 103.12 µM 0.996591221165486 0.198347198675787 no 702 0.159481484435508 799 5302957 SGTC_885 0865-0106 16.8 µM 0.995662586808047 0.198594131330243 no 703 0.159707057053065 791 2793380 SGTC_1981 st071826 47 µM 0.993701594044068 0.199116186658852 no 704 0.160184083231507 759 11838600 SGTC_2215 7188065 200 µM 0.992844496273702 0.199344622560095 no 705 0.160392870899264 770 940217 SGTC_2753 fluvastatin 17.09 µM 0.991997941320318 0.199570403393468 no 706 0.160599264833834 815 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5 SGTC_2249 haloperidol 116.36 µM 0.986308613451723 0.201091766962432 no 707 0.161990847141773 929 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_510 ag-490 170 µM 0.985731893453946 0.201246373003852 no 708 0.16213234723452 893 5328779 SGTC_1166 k206-0078 225 µM 0.984193679809289 0.201659082885767 no 709 0.162510146371013 843 5404595 SGTC_1317 1273-0028 910 nM 0.983952517231629 0.201723833869556 no 710 0.162569429978683 834 5917803 YLR359W | YHR072W ADE13 | ERG7 SGTC_3005 9076496 71.4286 µM 0.98367910868179 0.201797257799192 no 711 0.16263665744479 801 21368410 SGTC_1238 0333-0287 48.8 µM 0.981681782750797 0.202334125447175 no 712 0.16312832144771 812 7226 SGTC_1019 4262-0212 3.4 µM 0.98149323431727 0.20238485007415 no 713 0.163174784590213 891 4677213 SGTC_912 3474-0017 2.18 µM 0.981082432875358 0.202495393100457 no 714 0.163276046319938 845 3360550 SGTC_1713 st033146 12.748 µM 0.980699746090377 0.202598403191516 no 715 0.16337041456813 833 674619 SGTC_1853 st056710 91.2 µM 0.978049717764246 0.203312586182485 no 716 0.16402486747512 872 269167 SGTC_1965 Pectolinarigenin 58.4 µM 0.97556542591177 0.20398346561799 no 717 0.164639932422608 827 5320438 An anti-inflammatory. SGTC_1995 st072814 61.1 µM 0.975326024145432 0.204048185324978 no 718 0.16469928273928 791 5769371 SGTC_451 chloral hydrate 100 µM 0.974692812672512 0.2042194262329 no 719 0.164856329598907 888 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1 SGTC_2993 9054257 71.4286 µM 0.974481215243189 0.204276668108458 no 720 0.164908830854951 827 6470217 YGL055W OLE1 SGTC_429 1112-0049 25.5 µM 0.973464386109126 0.204551876551134 no 721 0.165161276088541 777 2836170 SGTC_1916 st067606 49.2 µM 0.973129843976226 0.204642469789209 no 722 0.165244386556235 869 19590279 SGTC_1547 harmine 94.2 µM 0.972049074279093 0.204935302808396 no 723 0.165513067632186 897 5280953 A monoamine oxidase inhibitor YHR072W ERG7 SGTC_3286 9117135 37.221 µM 0.97176894308537 0.205011244594262 no 724 0.165582754782831 775 3438150 SGTC_3303 9125618 40.5795 µM 0.971691315123397 0.205032292000999 no 725 0.165602069347201 892 22695467 SGTC_1845 st056753 3.01 µM 0.969053348139346 0.205748291814832 no 726 0.166259286204849 837 5375839 SGTC_2706 st078239 82.5 µM 0.966116258122049 0.206547223081429 no 727 0.166993005004434 837 15434492 SGTC_2718 lomofungin 53.02 µM 0.965754696048624 0.206645700103191 no 728 0.167083471496711 802 5351222 A RNA synthesis inhibitor. SGTC_2458 5808907 16.39 µM 0.963696026819512 0.207206940152092 no 729 0.167599173451089 906 2731747 SGTC_2049 5262831 67.185 µM 0.962481615609082 0.207538438606653 no 730 0.167903866862152 832 763417 SGTC_2120 5538279 151.968 µM 0.961370616876385 0.207841982854328 no 731 0.16818292640809 844 2058197 SGTC_3259 9138485 49.47 µM 0.959680747671814 0.208304186972821 no 732 0.168607957819592 919 17646153 SGTC_796 1234-0020 70.7 µM 0.956063032181052 0.209295721662905 no 733 0.169520195133429 805 46495034 SGTC_1735 st034310 56.75 µM 0.955773054422736 0.209375318138418 no 734 0.169593452296928 821 871153 SGTC_3041 9091929 49.47 µM 0.95530847105237 0.209502879522821 no 735 0.16971086245367 875 25236887 SGTC_1466 k213-0079 57.5 µM 0.952860036855449 0.210175904944484 no 736 0.170330495262325 867 3657981 SGTC_2468 5987765 72.9 µM 0.952306895410424 0.210328128096176 no 737 0.170470680907629 897 26772094 SGTC_3281 9140613 49.47 µM 0.952030661236734 0.210404171284067 no 738 0.170540716091091 773 16013766 SGTC_2359 9039622 200 µM 0.951646674305266 0.210509904021561 no 739 0.170638101029367 890 6463596 SGTC_2598 perillyl alcohol 100 µM 0.949925335762212 0.210984266341889 no 740 0.171075096107034 863 10819 An apoptosis inducer. SGTC_1008 4106-0037 6 µM 0.948247962520216 0.211447115108046 no 741 0.171501617712704 852 2905394 SGTC_3011 9081274 71.4286 µM 0.946337659074575 0.211974961386208 no 742 0.171988195605328 880 6625322 SGTC_1836 st055642 81 µM 0.945985232238062 0.212072426491036 no 743 0.172078059277686 859 8571 SGTC_2247 cerulenin 830 nM 0.94511738401532 0.212312545207409 no 744 0.172299475583472 845 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12 SGTC_89 0302-0250 142.109 µM 0.944538245528703 0.212472871248351 no 745 0.172447333722927 923 4203518 YLR208W SEC13 SGTC_333 3486-0131 40.1 µM 0.942775369165428 0.212961332960964 no 746 0.172897906413307 915 6744690 SGTC_2319 6033012 152.6 µM 0.939585358903428 0.213846891862541 no 747 0.173715144601398 785 847246 SGTC_1064 honokiol 6.76 µM 0.93795256792202 0.214300989217452 no 748 0.1741343931582 868 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis. SGTC_1243 0416-0003 5.65 µM 0.937832184082002 0.21433449149048 no 749 0.174165329317913 835 2141977 SGTC_3178 9107506 49.47 µM 0.936284196198303 0.214765560807554 no 750 0.174563441430613 855 8897194 SGTC_387 norethindrone acetate 66.7 µM 0.933425537997438 0.215562936121362 no 751 0.175300149896897 818 541197 SGTC_1723 st034307 2.5525 µM 0.932493469232295 0.215823291932303 no 752 0.175540780102557 877 867466 SGTC_1371 2421-0008 32.7 µM 0.929462325885606 0.216671243598872 no 753 0.17632477041396 839 2827552 SGTC_4 0960-0234 25.671 µM 0.928640914830763 0.216901361851419 no 754 0.176537605296612 840 6821112 SGTC_1454 4239-0054 42.6 µM 0.92848486589724 0.216945094913644 no 755 0.176578057316613 940 1340767 SGTC_2568 diosmetin 100 µM 0.924998722317175 0.21792342238339 no 756 0.177483286028152 901 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.  SGTC_1622 st003707 19.4 µM 0.924880525789423 0.21795663677676 no 757 0.177514028758079 915 10140899 SGTC_754 3474-0146 171 µM 0.924546986400637 0.218050380382776 no 758 0.177600799949148 806 24762078 SGTC_2941 9056145 11.23 µM 0.922912230622577 0.21851017606249 no 759 0.178026473166547 813 2119517 SGTC_1751 st044839 27.194 µM 0.921448331485401 0.218922389566042 no 760 0.178408202579605 882 5291326 SGTC_3048 9093155 49.47 µM 0.920608218589827 0.219159155478002 no 761 0.178627504892684 837 25236002 SGTC_2666 tannic acid 100 µM 0.920018016817648 0.219325577865525 no 762 0.178781672105743 917 16134267 A thiamine antagonist. SGTC_980 1473-0395 201 µM 0.919971457651654 0.219338709495416 no 763 0.178793837436916 820 768876 SGTC_386 1509-0011 3.07 µM 0.919115339678686 0.219580251053034 no 764 0.17901762329784 950 3107280 SGTC_1792 st045773 43.6 µM 0.91879852492386 0.219669674560092 no 765 0.179100482083222 862 2919270 SGTC_752 1896-0090 130 µM 0.918364499607701 0.219792215629132 no 766 0.179214034929302 906 772567 SGTC_456 gingerol 170 µM 0.918361463634999 0.219793072932381 no 767 0.179214829381908 924 442793 A herb. SGTC_1093 fluphenazine 7.97 µM 0.917975834379173 0.219901983197736 no 768 0.179315758761729 910 6602611 An atypical antipsychotic. SGTC_613 3914-0030 117 µM 0.916019033031553 0.220455104425679 no 769 0.179828456131342 674 1145395 SGTC_2883 9059145 45.46 µM 0.914862658387945 0.220782346704316 no 770 0.180131867813302 852 16476510 SGTC_2424 5537928 59.2 µM 0.914703341898163 0.220827453444585 no 771 0.18017369473632 914 5382802 SGTC_1405 3909-7894 12 µM 0.914236473651221 0.220959666660359 no 772 0.18029630134796 905 7104060 SGTC_496 calpeptin 138 µM 0.914102558425858 0.220997598702296 no 773 0.180331479157318 808 73364 A calpain inhibitor. SGTC_2243 6634756 200 µM 0.911354046527867 0.221776948891398 no 774 0.181054429005428 860 885676 SGTC_1377 2944-0135 198 µM 0.910019581385442 0.22215590664522 no 775 0.181406091560611 922 1894137 SGTC_1774 st048371 48.465 µM 0.908184800323647 0.222677545626102 no 776 0.18189029661677 921 4242727 SGTC_1488 4013-0813 75.9 µM 0.903549284030794 0.223998555464884 no 777 0.183117221985839 873 2910057 SGTC_3233 9132340 49.47 µM 0.902721855819354 0.224234819875245 no 778 0.18333676691114 874 17682950 SGTC_2235 salicylic acid 500 µM 0.901642086806853 0.224543350549012 no 779 0.18362351317395 907 338 A COX inhibitor and kinase inhibitor. SGTC_100 0086-0128 49.5915 µM 0.901236551430115 0.224659289467692 no 780 0.183731280353419 944 93297 SGTC_2373 9071805 200 µM 0.900587065131507 0.224845042479561 no 781 0.183903957243522 935 10149009 SGTC_90 0870-0863 4.608 µM 0.89949439273714 0.225157743051225 no 782 0.184194690590317 937 1738164 SGTC_1661 st013063 9.66 µM 0.89923948710304 0.225230727273557 no 783 0.184262555861543 975 721395 SGTC_2228 7354201 200 µM 0.899177653221447 0.225248433482739 no 784 0.184279020663712 923 753451 SGTC_1805 st050013 60.3 µM 0.898342736706712 0.225487590045327 no 785 0.184501427489786 888 4037144 SGTC_1047 2043-3044 82 µM 0.898192962235338 0.225530507196068 no 786 0.184541342383904 949 669592 SGTC_255 tunicamycin 200.472 nM 0.897718074572983 0.225666614523856 no 787 0.184667935443187 907 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_1821 st053465 65.6 µM 0.896483240520789 0.226020747175461 no 788 0.184997363677635 868 675086 SGTC_259 usnic acid 108.925 µM 0.896290174786934 0.226076144036136 no 789 0.185048902616812 928 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_2860 9025725 38.96 µM 0.895114823465179 0.226413556213777 no 790 0.185362855321035 856 40546248 SGTC_721 1187-1332 279 µM 0.894986802418583 0.226450324826352 no 791 0.18539707148506 820 25730 SGTC_2400 5203494 178.7 µM 0.891215246299481 0.227535055990945 no 792 0.186406853324513 846 6777674 SGTC_445 e6 berbamine 66 µM 0.891214866252302 0.227535165442939 no 793 0.186406955248237 995 6610268 A calcium/calmodulin antagonist. SGTC_952 1185-0122 232 µM 0.890883762030596 0.227630533335059 no 794 0.186495766221998 910 678600 SGTC_3327 9140648 26.9345 µM 0.890254080894522 0.22781196236492 no 795 0.186664735771712 923 8029710 SGTC_1287 0971-0001 34.6 µM 0.890174860015557 0.227834793913147 no 796 0.18668600072756 960 4665869 SGTC_607 4491-0986 66.8 µM 0.885820241103979 0.229091779030175 no 797 0.187857200389219 963 698981 YDR232W HEM1 SGTC_2013 4024628 200 µM 0.885370625521056 0.229221784273968 no 798 0.187978384963028 873 5230760 SGTC_407 eburnamonine 100 µM 0.883723355313882 0.229698441681325 no 799 0.188422784728491 863 3195 SGTC_2273 7815444 169.05 µM 0.883722979005757 0.229698550633984 no 800 0.18842288632269 922 2824616 SGTC_3128 9127691 49.47 µM 0.883574302958057 0.229741599140859 no 801 0.188463027945396 819 41316314 SGTC_1518 st038567 90.8 µM 0.88324745446622 0.229836252590909 no 802 0.188551293577224 924 77966 SGTC_1137 ixabepilone 100 µM 0.882631388807112 0.230014721022067 no 803 0.188717731765596 923 154225 A novel microtubule stabilizer. SGTC_640 3381-0960 37.1 µM 0.882375221150382 0.230088953206609 no 804 0.188786965453512 989 1745025 SGTC_720 r052-1644 49.9 µM 0.881556910576469 0.230326172770279 no 805 0.189008232721707 835 1422863 YOR257W CDC31 SGTC_1439 4092-1168 46 µM 0.881464085738779 0.230353090340851 no 806 0.189033342198568 940 2886240 SGTC_1707 st032323 6.317 µM 0.879904928283731 0.23080548139282 no 807 0.189455407356603 921 3132057 YMR211W DML1 SGTC_583 1488-1091 88.9 µM 0.878272797943748 0.231279576706368 no 808 0.18989784707452 1090 4303273 SGTC_817 1391-0715 46 µM 0.877765335362049 0.231427093231751 no 809 0.190035539954989 876 1353946 SGTC_2333 9017922 200 µM 0.876501652998015 0.231794666503176 no 810 0.190378689079147 951 3163164 SGTC_3193 9111931 49.47 µM 0.876232117875864 0.231873109522158 no 811 0.190451929737767 931 17087244 SGTC_2948 9070189 9.45 µM 0.874270268615191 0.232444513310451 no 812 0.190985543300338 851 6473636 YDL196W YDL196W SGTC_1497 4476-2978 41.3 µM 0.872804939071449 0.232871812289784 no 813 0.191384703529698 986 1528379 SGTC_121 0557-0495 61.343 µM 0.87145863952825 0.233264785742905 no 814 0.191751889903049 1152 3104427 SGTC_1097 itavastatin 7.23 µM 0.871238904144631 0.233328959561667 no 815 0.191811860905079 974 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49 SGTC_302 1094-0063 18.9 µM 0.869806871177916 0.23374742531653 no 816 0.19220297791207 874 5440289 SGTC_11 0438-0307 1.3 µM 0.867239679624846 0.23449864505334 no 817 0.19290534968776 950 4011476 SGTC_1028 k015-0029 4.8 µM 0.866634255439799 0.23467600063083 no 818 0.193071219124766 966 4588309 SGTC_1056 3448-1962 115 µM 0.865429072798966 0.235029272726007 no 819 0.193401664852642 906 715507 SGTC_3066 9117245 49.47 µM 0.863343209714817 0.235641390095544 no 820 0.193974396752218 1000 17176980 SGTC_3331 9141060 1.957 µM 0.861831265713647 0.236085634296419 no 821 0.194390188525883 907 4906567 YPR165W RHO1 SGTC_2019 4016004 108 µM 0.860842133955974 0.236376513628804 no 822 0.194662497824333 903 45595336 SGTC_2385 9074692 200 µM 0.860357594690724 0.236519076679832 no 823 0.194795976785597 939 17046906 SGTC_703 3875-0075 71.8 µM 0.859432760526558 0.236791316328838 no 824 0.195050900932741 1013 2850814 SGTC_1582 3',3',6'-trihydroxyflavone 74 µM 0.858873585375137 0.236956001984992 no 825 0.195205132033229 912 688803 SGTC_2715 st079500 56.4 µM 0.858650471912391 0.23702172988872 no 826 0.195266691632473 907 28246688 SGTC_1814 st052110 31.539 µM 0.858018315100604 0.237208013941471 no 827 0.195441175097378 967 674163 SGTC_1738 st035555 74 µM 0.85691102900145 0.237534502876976 no 828 0.195747028516946 964 5331140 SGTC_1415 3966-0071 78.1 µM 0.856476614111434 0.237662659645583 no 829 0.195867101452927 956 2893185 SGTC_1407 3909-7909 12.3 µM 0.855916783510706 0.23782787124337 no 830 0.196021905376831 989 4411780 SGTC_3072 9116419 49.47 µM 0.855898612054651 0.237833234876596 no 831 0.196026931377075 933 17170162 SGTC_2055 5235184 200 µM 0.855184620842599 0.238044034772537 no 832 0.196224474397701 938 2836034 SGTC_245 methotrexate 289.6 µM 0.854318489968236 0.238299890029425 no 833 0.19646427250984 978 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2 SGTC_2390 9097792 176.6 µM 0.854300905434605 0.238305086064285 no 834 0.196469142825157 917 4497149 SGTC_197 4544-0043 41.561 µM 0.852864875801888 0.238729626306915 no 835 0.196867120914907 1013 896523 SGTC_954 1189-0853 2.85 µM 0.851855632294023 0.239028241170931 no 836 0.197147112284812 1026 2828194 SGTC_1160 4092-0570 10.5 µM 0.847999396947845 0.240171102134896 no 837 0.198219153290369 964 4994975 SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM 0.847422390631339 0.240342363564718 no 838 0.198379864302556 936 5379071 SGTC_1657 st012939 43.4 µM 0.847349655145153 0.240363956928611 no 839 0.19840012857413 952 24207257 SGTC_3121 9125696 49.47 µM 0.847159244395548 0.24042049016723 no 840 0.198453183355676 999 1235365 SGTC_3045 9092950 49.47 µM 0.846924657054298 0.240490149458826 no 841 0.19851855897586 995 44120432 SGTC_2951 9072950 58.06 µM 0.845554435097746 0.240897248083134 no 842 0.198900676714594 1064 16488155 SGTC_2037 5169046 200 µM 0.844357182146208 0.241253263550053 no 843 0.199234920724536 987 5718022 SGTC_2634 4'-methoxyflavone 100 µM 0.843703492242723 0.241447765573355 no 844 0.19941755779131 918 77793 From seeds of Psoralea corylifolia (Fabaceae) SGTC_3051 9093778 49.47 µM 0.841847592753351 0.242000442686692 no 845 0.199936634085755 951 17217378 SGTC_321 4534-3890 65.3 µM 0.839506201984008 0.242698674278403 no 846 0.200592655186761 1015 699746 SGTC_924 2046-0044 21.3 µM 0.835941280198454 0.243763868905459 no 847 0.201593968938753 1043 3623589 SGTC_411 enrofloxacin 100 µM 0.83507736615722 0.244022384815202 no 848 0.201837074757681 1039 71188 A bacterial gyrase inhibitor. SGTC_2818 7996756 12.99 µM 0.834654805202763 0.24414888494785 no 849 0.201956047508399 958 2241621 SGTC_1648 st011736 69.8 µM 0.833048593037312 0.244630051811348 no 850 0.202408662157743 983 2855514 SGTC_1406 3909-7906 11.9 µM 0.832437915234221 0.244813124135482 no 851 0.202580904127873 1006 X1406 SGTC_237 nikkomycin 200 µM 0.832282398440079 0.2448597575872 no 852 0.202624781707626 996 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine. SGTC_452 diindolylmethane 8 µM 0.832175686147531 0.244891759228291 no 853 0.202654892848607 912 3071 Inhibits expression of several cancer promoting factors. SGTC_926 2268-1401 59.4 µM 0.831886537840638 0.244978482389319 no 854 0.202736495626907 1039 2931578 SGTC_2360 9040895 200 µM 0.830347168163762 0.245440457743619 no 855 0.203171263444304 935 4914414 SGTC_1978 st071761 42 µM 0.829674408996574 0.245642504267932 no 856 0.203361447044482 945 5147680 SGTC_2779 methotrexate 400 µM 0.828290315885642 0.246058463063251 no 857 0.203753052943257 1092 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2 SGTC_1811 st050069 61.5 µM 0.82783011688748 0.246196849422751 no 858 0.203883358040634 1020 3877702 SGTC_1293 1000-1278 195 µM 0.826561094786231 0.246578672959302 no 859 0.204242938170294 1015 678847 SGTC_3294 9122953 26.2835 µM 0.825366305096155 0.246938451153404 no 860 0.204581829294544 1065 16459826 SGTC_675 1309-0189 238 µM 0.823187560272581 0.247595243035577 no 861 0.205200670925576 983 4246530 SGTC_2728 chlorpromazine 9.18 µM 0.821586650962759 0.248078438043322 no 862 0.205656094638093 958 2726 A thorazine and dopamine antagonist. SGTC_819 1013-0258 27.7 µM 0.821090652881289 0.248228244844052 no 863 0.205797316893891 1005 5753198 SGTC_1337 1486-1011 40.3 µM 0.818784814107117 0.248925312598116 no 864 0.206454598291323 1064 X1337 SGTC_1524 corynanthine 62.1 µM 0.818248966484311 0.249087451338502 no 865 0.206607520040587 977 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist. SGTC_2512 diallyl trisulfide 49.23 µM 0.818034215465645 0.249152447256367 no 866 0.206668825134591 1026 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent SGTC_2539 epi(13)torulosol 80 µM 0.816504820100248 0.249615590363891 no 867 0.20710573392353 1005 6708597 SGTC_256 clotrimazole 625 nM 0.815396537283437 0.249951494533222 no 868 0.207422682892334 992 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C SGTC_870 0573-2213 57.6 µM 0.815380250441245 0.249956432622714 no 869 0.207427342773304 1033 3916321 SGTC_3337 9144342 33.5465 µM 0.815094992197955 0.25004292989618 no 870 0.207508968963017 1023 17682949 SGTC_1559 coumarin 343 70.1 µM 0.813610478685126 0.250493326942228 no 871 0.207934066501022 985 108770 A hepatotoxic, DNA x-linker. SGTC_440 fluspirilene 35.1 µM 0.812346443463163 0.250877170126539 no 872 0.208296434002724 1014 3396 An atypical antipsychotic. SGTC_96 0929-0093 37.281 µM 0.810065713521328 0.251570534766533 no 873 0.208951204352044 976 6991579 SGTC_1884 5633444 25 µM 0.810002771188188 0.251589684208144 no 874 0.208969291519202 1018 5724239 SGTC_189 3970-0742 2.116 µM 0.808947106239904 0.251910972196476 no 875 0.209272785792874 1042 2891807 SGTC_2354 9060492 162 µM 0.8087030271724 0.251985287630119 no 876 0.209342993261189 1060 6471895 SGTC_1176 0848-0131 83.3 µM 0.807672103183941 0.252299303509608 no 877 0.209639683502634 1100 6769040 SGTC_1161 k007-0610 110 µM 0.807433231748645 0.252372092350957 no 878 0.209708463728588 1098 5843850 SGTC_1077 5-fluorocytosine 377 nM 0.806695438663912 0.252596982342179 no 879 0.209920986353018 999 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_3167 9103034 49.47 µM 0.806369763738879 0.252696286338316 no 880 0.210014837855119 1018 5127859 SGTC_1505 k297-0037 20.6 µM 0.805767273570578 0.252880050341407 no 881 0.210188525680379 1002 4089396 SGTC_61 0978-8327 98.565 µM 0.804866141576328 0.253155033557919 no 882 0.21044846434543 1093 6150059 YHR072W ERG7 SGTC_2251 lansoprazole 556 µM 0.804713466936368 0.253201638271657 no 883 0.210492523240924 859 3883 Gastric proton pump inhibitor. YBR192W RIM2 SGTC_553 k007-0256 45.7 µM 0.803937777439943 0.253438491130187 no 884 0.210716455571669 1055 6287000 SGTC_2256 7954252 200 µM 0.802006632748757 0.254028661772322 no 885 0.211274560752562 914 2972920 SGTC_17 0960-0276 49.807 µM 0.801726096363821 0.254114455494369 no 886 0.21135570838054 1092 6821114 SGTC_1321 1326-2144 215 µM 0.801169856884847 0.254284609751398 no 887 0.211516659538405 1041 3513030 SGTC_1693 xanthone 101.9 µM 0.80085584792615 0.254380691801969 no 888 0.211607551556433 1053 7020 An insecticide. SGTC_2969 9091408 28.7 µM 0.800187132582971 0.254585372099635 no 889 0.211801191912815 970 4286311 SGTC_3203 9113543 49.47 µM 0.800096492471554 0.254613121849576 no 890 0.211827446608402 1011 17018012 SGTC_709 3807-1509 243 µM 0.797927920867031 0.255277508826854 no 891 0.212456159767472 1043 1886677 YPL242C IQG1 SGTC_75 0159-0059 199.013 µM 0.794625704411828 0.256290949600747 no 892 0.213415630770853 1016 5377270 SGTC_252 miconazole 1.30953 nM 0.793545311940343 0.256622973692187 no 893 0.213730090243588 1019 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_2690 usnic acid 100 µM 0.793283905369613 0.256703342288457 no 894 0.213806215875935 1099 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_2909 7941780 10.49 µM 0.792105433477063 0.257065822261601 no 895 0.21414960109263 1061 1243215 SGTC_3318 9139014 38.6185 µM 0.791365539964355 0.257293538178549 no 896 0.214365356456662 1015 16643984 SGTC_1683 st010134 710 nM 0.788620598741365 0.258139259710085 no 897 0.215166893962323 1078 3818134 SGTC_320 4092-0846 5.34 µM 0.787442360283487 0.258502718803873 no 898 0.215511478829269 1065 1359356 SGTC_2294 7971431 200 µM 0.787312438792787 0.258542812773441 no 899 0.215549494947441 975 5741572 SGTC_2239 6685329 187.64 µM 0.787224225767541 0.258570037282683 no 900 0.215575309035296 1020 805680 SGTC_1242 0402-0103 60.1 µM 0.7865745931098 0.258770574138052 no 901 0.215765468532887 1016 432868 SGTC_2250 alverine citrate 130 µM 0.786026175447974 0.258939929299575 no 902 0.215926076188327 1046 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1 SGTC_2595 hexamethylquercetagetin 100 µM 0.784184736367675 0.259508997573502 no 903 0.216465860036315 992 386331 SGTC_1192 1488-0095 21.4 µM 0.783997793243072 0.259566805546356 no 904 0.21652070258533 1010 915875 SGTC_2485 5633444 17.78 µM 0.783908389484354 0.259594454005749 no 905 0.216546933350553 1031 5724239 SGTC_2516 gossypol 71.55 µM 0.783793304081454 0.259630046851567 no 906 0.216580701731113 1081 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_6 0844-0013 19.835 µM 0.783745175335106 0.259644932536289 no 907 0.21659482458025 1212 1584900 SGTC_215 1287-0124 461.5 µM 0.780277600924758 0.260718572821467 no 908 0.217613747082841 1063 5560863 SGTC_2572 astragaloside iv 100 µM 0.779139206137828 0.261071543329631 no 909 0.217948858584034 1040 45006101 An anti-inflammatory agent. SGTC_2770 toltrazuril 17.5 µM 0.779060358395328 0.261095999941535 no 910 0.217972080161602 1083 68591 Kills coccidiodes. SGTC_2580 diallyl disulphide 81.36 µM 0.778693575055055 0.261209782505146 no 911 0.218080120873725 1014 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.  SGTC_3146 9095609 49.47 µM 0.776315134936473 0.261948233766633 no 912 0.218781469437937 1052 17173999 SGTC_482 fipronil 114 µM 0.773501742903696 0.262823107492337 no 913 0.21961274883324 1082 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels. SGTC_791 1348-1292 225 µM 0.771551390466251 0.263430479703119 no 914 0.220190086973873 1120 5437054 SGTC_944 3370-0224 231 µM 0.766580467834378 0.264981741496229 no 915 0.221665496074327 1110 4580514 SGTC_2315 7733312 200 µM 0.765904970967944 0.265192899562528 no 916 0.221866423951761 1059 726316 SGTC_1887 st057648 70.8 µM 0.765011444414296 0.26547234418605 no 917 0.22213236492313 1086 688672 SGTC_1016 4226-1401 38 µM 0.763864568359668 0.265831241036792 no 918 0.222473976981859 1114 2901613 SGTC_1338 1486-1223 76 µM 0.76360780425028 0.265911625009399 no 919 0.222550498561328 1100 3444526 SGTC_231 b-estradiol 524 µM 0.763597172949538 0.265914953567914 no 920 0.222553667255711 1052 450 A steroid. SGTC_2224 6650123 117.647 µM 0.761785668717208 0.266482426305186 no 921 0.223093967587317 1061 2908370 SGTC_2671 danthron 100 µM 0.761383260363485 0.266608568050109 no 922 0.223214091449339 1076 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin. SGTC_793 0488-0545 106 µM 0.761014868386315 0.266724073248102 no 923 0.223324093277276 1068 292548 SGTC_1005 4092-0690 4.4 µM 0.760206885679196 0.266977495762324 no 924 0.223565464878176 1057 1529343 SGTC_1504 k297-0033 30 µM 0.758826020327743 0.267410883359169 no 925 0.223978319059963 1009 4388117 SGTC_3070 9117005 49.47 µM 0.758170945328924 0.267616604103552 no 926 0.224174326225234 1095 8779016 SGTC_1198 1612-1005 86.7 µM 0.757808578879472 0.267730436472883 no 927 0.224282792925497 1139 6998509 SGTC_877 0771-0151 33.1 µM 0.757658065014744 0.267777725476491 no 928 0.224327854810945 1101 6166523 SGTC_2332 7982454 138.89 µM 0.756494468152602 0.26814345061571 no 929 0.224676393916839 1083 2981748 SGTC_1917 st066507 28.5 µM 0.753738065556583 0.269010805580028 no 930 0.225503259994018 1077 3156428 SGTC_1219 1469-0211 33.1 µM 0.750808233521657 0.269934274813859 no 931 0.22638403678945 1092 6822282 SGTC_2564 betulinic acid 100 µM 0.750427756976559 0.270054315527917 no 932 0.226498559403928 1143 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14 SGTC_2111 5486399 200 µM 0.749273495177914 0.27041864957374 no 933 0.226846189768685 1141 689674 SGTC_2961 9083290 32.55 µM 0.748923834066374 0.270529065929475 no 934 0.226951556979257 1064 17741490 SGTC_3192 9110362 49.47 µM 0.748849025277771 0.270552692052539 no 935 0.226974103514293 1145 16649480 SGTC_2138 5575593 77.673 µM 0.748511088256828 0.270659432217771 no 936 0.22707596970544 1127 762213 SGTC_794 k038-0031 316 µM 0.746837807611008 0.271188261231611 no 937 0.22758073538073 1147 6624242 SGTC_2893 9048488 25.97 µM 0.746787074501788 0.271204303129984 no 938 0.227596049508637 1091 6467338 SGTC_3218 9131285 49.47 µM 0.743021691904269 0.272396242669131 no 939 0.228734273800602 1130 17156417 SGTC_2089 5281248 129.67 µM 0.742139568125106 0.272675856473941 no 940 0.229001389218445 1120 2737878 SGTC_342 k048-0088 23.3 µM 0.741684365606116 0.272820201340464 no 941 0.229139297273617 1118 6820570 SGTC_2101 5377231 179.231 µM 0.740028951069513 0.273345453175829 no 942 0.229641213814635 1121 2844213 SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM 0.739604499831213 0.273480209302801 no 943 0.229770005235128 1188 368090 SGTC_1951 sophoraflavanone G 9.2 µM 0.738631007973311 0.273789400741783 no 944 0.230065544996148 1169 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity. SGTC_3103 9120822 49.47 µM 0.737731134286978 0.274075363935582 no 945 0.23033892429651 1175 17141819 SGTC_3105 9121040 49.47 µM 0.732841037631447 0.275631921205742 no 946 0.231827694279486 970 41448907 SGTC_2731 amoxapine 43.43 µM 0.732009739304456 0.275896961776012 no 947 0.232081311647639 1157 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine. SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM 0.728279377458355 0.277087841978734 no 948 0.233221291850846 1201 6708561 SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM 0.727684642365808 0.277277937373439 no 949 0.233403326789683 1108 5711223 A potent inhibitor of glutathione S-transferases. SGTC_144 4161-2749 112.381 µM 0.727535125287955 0.277325737602986 no 950 0.233449102976356 1043 797501 YMR168C CEP3 SGTC_3080 9117754 49.47 µM 0.726946325358739 0.277514014613321 no 951 0.233629418526224 1177 9550191 SGTC_2188 6126565 140.678 µM 0.726070927178642 0.277794050848522 no 952 0.23389764533004 1101 874518 SGTC_2508 celastrol 40.54 µM 0.725479153349412 0.27798343496514 no 953 0.234079064692683 1113 122724 Celastrol is a natural product and antioxidant. SGTC_1411 3909-8223 150 µM 0.724899881097652 0.278168879228669 no 954 0.234256726914909 1177 X1411 SGTC_2917 7979103 53.79 µM 0.723812314266136 0.278517208331823 no 955 0.234590484114266 1156 2980565 SGTC_26 0302-0163 425.158 µM 0.723664062350518 0.278564707342753 no 956 0.234636000661854 1183 3100915 SGTC_806 3966-4455 5.86 µM 0.720881759606592 0.279456871307046 no 957 0.235491133157425 1075 714982 SGTC_1063 disulfiram 1.84 µM 0.720679666539733 0.279521727818675 no 958 0.235553312781953 1163 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_1924 st058459 75.1 µM 0.719952019177847 0.279755307820059 no 959 0.235777268990967 1145 688683 SGTC_733 4069-0007 56.1 µM 0.719842930211415 0.279790334319162 no 960 0.235810854645744 1177 5717425 YNL287W SEC21 SGTC_1785 bathophenanthroline 24 µM 0.717299818587335 0.280607483930214 no 961 0.23659455957637 1089 72812 An iron chelator. SGTC_532 1548-0774 215 µM 0.716990312040174 0.280707012970267 no 962 0.236690037226343 1213 5932993 SGTC_154 3389-1638 511.116 µM 0.716807379101815 0.280765847345396 no 963 0.236746478975467 1109 5238686 SGTC_201 4262-0159 12.803 µM 0.71396258499298 0.281681548603181 no 964 0.237625157797169 1121 1341029 SGTC_484 loperamide 105 µM 0.711491606567086 0.282478090306782 no 965 0.238389825114645 1123 3955 An opioid-receptor agonist. SGTC_1565 sinapyl alcohol 95.1 µM 0.710755053859731 0.282715733955766 no 966 0.2386180186386 1163 5280507 A phenol propionate derived from cinnamic acid. SGTC_2437 5741531 144.16 µM 0.709522940226505 0.283113481541633 no 967 0.239000010427168 1231 2262990 SGTC_756 0508-1999 28.3 µM 0.709510558758348 0.283117479856034 no 968 0.239003850745681 1161 6753853 SGTC_461 N-acetylfarnesylcysteine 136 µM 0.708808655216439 0.283344187986292 no 969 0.239221612974138 1207 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ). SGTC_1111 tnp00062 510.699 nM 0.707619719511142 0.283728401330753 no 970 0.239590721825423 1223 676306 SGTC_648 0375-0473 33.3 µM 0.707335447711045 0.283820302805283 no 971 0.239679020934916 1171 1713139 SGTC_2034 5197015 53.07 µM 0.704578143812016 0.284712442928389 no 972 0.240536401976376 1173 780676 SGTC_2134 5324836 1.464 µM 0.703958310006724 0.284913177521477 no 973 0.240729368356433 1133 699272 SGTC_649 1123-0311 367 µM 0.703688171991221 0.285000683451743 no 974 0.240813493953465 1165 693629 YIL048W NEO1 SGTC_229 benomyl 22.8748 µM 0.702249452641239 0.285466944225696 no 975 0.241261805095223 1192 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C SGTC_1588 farnesol 29.9 µM 0.702020572332944 0.285541153323679 no 976 0.241333166978099 1204 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_1787 fluconazole 80 µM 0.700127879360658 0.286155166501515 no 977 0.241923723176982 1117 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C SGTC_2470 5664817 21.68 µM 0.699489758075444 0.28636232227708 no 978 0.242123005720469 1226 2859561 SGTC_469 w7 172 µM 0.698673816496653 0.286627308199588 no 979 0.24237795038958 1234 45115570 A P450 inhibitor. SGTC_3090 9117696 49.47 µM 0.697876269294106 0.286886432681466 no 980 0.242627288152907 1160 7923821 SGTC_1790 st045711 43.5 µM 0.695492940412651 0.287661441171224 no 981 0.243373216916716 1213 585119 SGTC_2662 daunorubicin 22.37 µM 0.694723840318313 0.287911747365025 no 982 0.243614192289247 1167 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_263 alizarin 107.927 µM 0.693746990843153 0.288229814475924 no 983 0.24392044561207 1205 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. SGTC_63 0099-0242 26.702 µM 0.692961625341815 0.288485653570499 no 984 0.244166817115029 1212 3898502 YLR359W ADE13 SGTC_760 0568-0725 82.9 µM 0.691466541686824 0.288972984595801 no 985 0.24463619993856 1206 3916171 SGTC_911 3456-4043 236 µM 0.689470682870974 0.289624149120822 no 986 0.245263558125467 1248 914281 SGTC_1603 st002045 67.8 µM 0.689059716263441 0.289758315656277 no 987 0.245392844534679 1208 5887985 SGTC_1465 k213-0056 144 µM 0.688907594067461 0.289807985742376 no 988 0.2454407100994 1126 24048857 YMR208W ERG12 SGTC_2314 7727897 200 µM 0.688678981263032 0.28988263862408 no 989 0.245512653026913 1205 900724 SGTC_3024 9090631 49.47 µM 0.687646380130996 0.290219944001635 no 990 0.245837746832935 1169 25236383 SGTC_1869 3',7'-dimethoxyflavone 40.3 µM 0.68702915256591 0.290421652863174 no 991 0.246032178861977 1216 688664 SGTC_1140 3229-1848 2.98 µM 0.686783560771149 0.290501930069578 no 992 0.246109565341395 1216 2849525 SGTC_2365 9042475 200 µM 0.686431552499305 0.290617010003664 no 993 0.246220506634509 1236 6464479 SGTC_1068 loratadine 26.9 µM 0.68570626838282 0.290854189968963 no 994 0.246449176572068 1204 3957 A H1 histamine antagonist. SGTC_837 0091-0265 12.5 µM 0.685634078899557 0.290877802080618 no 995 0.246471942932966 1176 759367 SGTC_2942 9052777 62.25 µM 0.682402721127049 0.291935647830947 no 996 0.247492167800556 1298 6469503 SGTC_1888 azatryptophan 97.5 µM 0.678447859813064 0.293232778803168 no 997 0.24874388624589 1184 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides SGTC_799 1310-0557 151 µM 0.678039509163951 0.293366863294459 no 998 0.248873321456875 1242 5354492 SGTC_698 k064-0052 127 µM 0.677389954570938 0.293580207127416 no 999 0.249079285110576 1271 5088751 SGTC_1438 4092-1045 4 µM 0.677315196990575 0.293604765590476 no 1000 0.249102995393374 1216 1351342 SGTC_158 k038-0087 26.446 µM 0.676484433629626 0.293877741989312 no 1001 0.249366562961684 1186 X158 SGTC_3231 9132313 49.47 µM 0.675563040878857 0.294180635071575 no 1002 0.249659056854083 1226 4905967 SGTC_2904 7225135 42.03 µM 0.675438898564261 0.294221455889305 no 1003 0.249698479455515 1306 4446116 SGTC_455 paf C-16 10 µM 0.674234720302037 0.294617552826269 no 1004 0.25008104949545 1205 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis. SGTC_325 2810-4341 181 µM 0.673998579491429 0.294695256754829 no 1005 0.250156108393968 1228 774970 SGTC_292 k038-0015 474 µM 0.671824949032962 0.295410949873145 no 1006 0.250847571854452 1230 46368540 SGTC_633 0437-0093 97.7 µM 0.670445317530157 0.295865624004294 no 1007 0.25128697703731 1237 2831118 SGTC_714 4296-0578 26.1 µM 0.66944426151038 0.296195735116297 no 1008 0.251606062563759 1232 1589775 SGTC_3126 9127922 49.47 µM 0.668992209245907 0.296344860527774 no 1009 0.251750223853631 1272 45595682 SGTC_2729 fluphenazine 10.66 µM 0.668787499722218 0.296412402519047 no 1010 0.251815520890875 1188 3372 An atypical antipsychotic. SGTC_134 0269-0018 6.916 µM 0.666847525916501 0.297052828710158 no 1011 0.252434765903513 1172 4378915 SGTC_1352 1496-0991 99 µM 0.666825909384485 0.29705996834605 no 1012 0.252441670478655 1239 3000039 SGTC_712 r015-0009 80.6 µM 0.661752813333098 0.298737706099636 no 1013 0.25406482579674 1217 6813872 YLR060W FRS1 SGTC_2287 7945887 168.79 µM 0.661552639023614 0.298803994548569 no 1014 0.254128984377001 1269 1245853 SGTC_396 dithiazanine 1.25 µM 0.661545069536566 0.298806501342831 no 1015 0.254131410666967 1226 10578 An antihelmenthic. SGTC_1143 3454-2408 5.08 µM 0.660413111338678 0.29918148054594 no 1016 0.254494380268401 1210 X1143 SGTC_1615 st002656 86.5 µM 0.658039976840604 0.299968311513332 no 1017 0.255256221707778 1259 1584458 SGTC_1459 k035-0031 35.7 µM 0.657875764099109 0.300022792132781 no 1018 0.255308982586243 1148 3877128 YMR208W ERG12 SGTC_1658 st012944 20 µM 0.657261893721348 0.300226494640242 no 1019 0.255506267090357 1206 24207260 SGTC_1276 0871-0068 94.2 µM 0.654944762778336 0.300995958183699 no 1020 0.256251659338637 1226 3414906 SGTC_559 1550-0661 158 µM 0.654623136127563 0.301102832900994 no 1021 0.256355212162428 1292 5830875 SGTC_1054 3429-0080 167 µM 0.651926590466917 0.301999551658002 no 1022 0.257224265166338 1276 1162877 SGTC_628 1636-0253 16 µM 0.65161923014266 0.302101838446986 no 1023 0.257323419568721 1250 4456143 SGTC_2009 4012297 12.05 µM 0.651330021647309 0.302198098669656 no 1024 0.257416736329523 1252 45595307 SGTC_2777 climbazole 1.536 µM 0.650372705133393 0.302516830274631 no 1025 0.257725751931818 1247 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2 SGTC_2889 9059656 51.95 µM 0.649274357030853 0.30288270284492 no 1026 0.258080528686669 1322 3949838 SGTC_1872 amphotericin b 148 nM 0.647625344782827 0.30343237969589 no 1027 0.25861365028982 1264 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1 SGTC_580 1123-0028 41 µM 0.647560657866737 0.303453951322292 no 1028 0.25863457502741 1317 1677248 YPR107C YTH1 SGTC_1033 k072-0102 21.3 µM 0.646128491019011 0.303931722014066 no 1029 0.259098072679719 1248 5965931 SGTC_1896 st058441 89 µM 0.641126831700057 0.305602899722924 no 1030 0.260720141354195 1231 688759 SGTC_1985 st071382 65.5 µM 0.636587345340831 0.307123168951873 no 1031 0.262196835106666 1307 6123237 SGTC_2474 5321570 43.32 µM 0.636493118393938 0.30715476073225 no 1032 0.262227532444468 1317 2841384 SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM 0.634619560090798 0.307783211769344 no 1033 0.26283828395727 1333 364106 SGTC_1452 4194-0072 190 µM 0.63449144267585 0.307826207059477 no 1034 0.262880074843039 1369 1343545 SGTC_2877 9040724 71.43 µM 0.63400480338847 0.307989543774864 no 1035 0.263038843679524 1307 6463895 SGTC_379 3970-0972 5.9 µM 0.633712773321692 0.308087579677146 no 1036 0.263134143673578 1301 2898042 YBL034C STU1 SGTC_654 1124-0271 80.9 µM 0.631597018066688 0.308798257605921 no 1037 0.263825117792618 1284 5403748 SGTC_1740 st038286 13.222 µM 0.63155419886035 0.308812647897386 no 1038 0.263839111452203 1319 716786 SGTC_13 0199-0087 65 µM 0.63064250625011 0.309119110930075 no 1039 0.264137149681272 1310 4589825 SGTC_1264 0783-0040 158 µM 0.630102352193357 0.30930074497427 no 1040 0.264313810417512 1266 2855798 SGTC_616 4092-0450 108 µM 0.628676422132031 0.309780456921792 no 1041 0.264780458531179 1326 787165 SGTC_889 0919-1524 82.7 µM 0.627027075004899 0.310335735209652 no 1042 0.265320743811584 1284 3905452 SGTC_2975 9084847 53.72 µM 0.625873557586672 0.31072434191119 no 1043 0.265698939823607 1340 27211724 SGTC_2727 riluzole 51.77 µM 0.624343034084956 0.311240283683525 no 1044 0.266201163871374 1307 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.  SGTC_1983 st071813 46.9 µM 0.623583646856504 0.311496412055912 no 1045 0.266450526494966 1299 11838595 SGTC_3250 9135583 49.47 µM 0.622869728960806 0.311737287623058 no 1046 0.266685065912422 1338 7699353 SGTC_1681 tripelennamine 100 µM 0.621394296849048 0.312235352958477 no 1047 0.267170111787111 1301 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist. SGTC_436 n,n-dimethylsphingosine 3.3 µM 0.620739481341727 0.312456510738885 no 1048 0.267385523888295 1402 5282309 SGTC_1669 st015249 58.4 µM 0.620680453748058 0.312476450074603 no 1049 0.267404946269252 1369 722793 SGTC_1968 st069590 43.6 µM 0.619244436535507 0.312961701206976 no 1050 0.267877671084477 1255 6384066 SGTC_332 4112-0506 40.9 µM 0.618839726873294 0.313098517092964 no 1051 0.268010974098763 1323 2790355 SGTC_1986 st071812 45 µM 0.618068027648979 0.313359468547121 no 1052 0.268265248428015 1311 11838594 SGTC_1165 k072-0275 30.3 µM 0.61530658808168 0.314294019127102 no 1053 0.269176133794884 1323 6153523 YGL055W OLE1 SGTC_182 3448-4371 550.524 µM 0.61522716656942 0.314320915308492 no 1054 0.269202354623186 1360 3491403 SGTC_977 1348-1378 135 µM 0.61426918200443 0.314645415448374 no 1055 0.269518731911024 1296 X977 SGTC_972 1319-0219 195 µM 0.61404304787582 0.314722035242464 no 1056 0.269593440563221 1283 23903702 SGTC_284 0988-0104 32.6 µM 0.613228024781329 0.314998251246474 no 1057 0.269862788398822 1322 4666532 SGTC_2701 st077767 14.721 µM 0.613097732666149 0.315042417590985 no 1058 0.269905859664187 1319 5721188 SGTC_550 4123-0385 25.7 µM 0.61240314494567 0.3152779131431 no 1059 0.270135530782611 1302 5731123 SGTC_1750 st081859 2.357 µM 0.6117928781988 0.315484882168098 no 1060 0.270337401124755 1317 5291695 SGTC_1266 0828-0227 32.9 µM 0.610073076233001 0.316068456049416 no 1061 0.270906700401339 1329 3913820 SGTC_1957 st077035 62.4 µM 0.609421168171894 0.316289785481723 no 1062 0.271122655221647 1400 705593 SGTC_940 3232-1287 54.8 µM 0.60853934021023 0.316589279808593 no 1063 0.271414911169942 1310 1585493 YIL048W NEO1 SGTC_3196 9111891 49.47 µM 0.607581554059533 0.316914708018539 no 1064 0.271732518947412 1316 18891510 SGTC_3092 9117248 49.47 µM 0.604090652503342 0.318102013932836 no 1065 0.272891686918886 1380 17141857 SGTC_3245 9134821 49.47 µM 0.603423598703277 0.318329101910569 no 1066 0.27311346357548 1283 17014901 SGTC_2495 cafestol 54.53 µM 0.60223796898167 0.318732899419259 no 1067 0.273507872509872 1348 16667697 An anti-infammatory. SGTC_2241 6772625 37.8075 µM 0.599262398270944 0.319747256075149 no 1068 0.274498959166945 1270 2285411 SGTC_2325 6158266 200 µM 0.598982971886963 0.319842580518913 no 1069 0.274592119902634 1348 3623240 SGTC_512 prima-1 270 µM 0.598429072717736 0.320031574686197 no 1070 0.274776835932704 1386 322968 A re-activator of the apoptotic function of mutant p53. SGTC_2990 9074105 71.4286 µM 0.598080325631531 0.320150593534814 no 1071 0.274893168622203 1328 6502001 SGTC_48 0382-0018 55 µM 0.597226074354331 0.320442206770598 no 1072 0.275178226477191 1439 762596 SGTC_1269 0831-0796 3.05 µM 0.59625978102924 0.320772201134469 no 1073 0.27550084733475 1350 927758 SGTC_1156 4092-0367 4.88 µM 0.595983538061386 0.320866565643491 no 1074 0.275593112046302 1345 1357585 SGTC_1769 st044406 64.4 µM 0.595439554861076 0.321052423961654 no 1075 0.275774845977356 1350 670903 SGTC_2956 9076196 2.52 µM 0.592179778598833 0.322167103332098 no 1076 0.276865104431271 1380 16423868 SGTC_1729 st035615 45.989 µM 0.590508460922784 0.322739231524773 no 1077 0.277424907511246 1340 17385451 SGTC_1392 3455-1037 33.9 µM 0.590395704104359 0.322777845756217 no 1078 0.277462695000887 1378 981132 SGTC_3170 9103054 49.47 µM 0.590283667389168 0.322816215276786 no 1079 0.277500243658414 1293 16432970 SGTC_1339 1486-1321 22.7 µM 0.589513513082273 0.323080023162217 no 1080 0.277758424989221 1352 3469382 SGTC_1155 4088-0394 48.2 µM 0.589240398794213 0.323173596844824 no 1081 0.277850010145742 1310 2326248 SGTC_2006 4011487 200 µM 0.588801562793281 0.323323973087647 no 1082 0.277997198689088 1429 45595294 SGTC_1975 st070967 30.8 µM 0.587320439017731 0.323831723845943 no 1083 0.278494258281442 1361 261391 SGTC_1205 4161-2785 76 µM 0.585974883633299 0.324293284201884 no 1084 0.278946196646518 1323 3498106 SGTC_971 1315-0384 26.7 µM 0.585217278161411 0.324553281418477 no 1085 0.279200814251312 1350 6769120 SGTC_2513 baicalein 25.65 µM 0.584748989002418 0.324714033015879 no 1086 0.279358254308055 1303 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2 SGTC_1688 st021091 57.6 µM 0.58336353556534 0.325189814588653 no 1087 0.279824299828063 1382 3656366 SGTC_2677 mitomycin C 100 µM 0.58278070576578 0.325390050687659 no 1088 0.280020467568783 1365 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_1159 4092-0538 61.2 µM 0.582742200588633 0.32540328124237 no 1089 0.280033429915064 1404 717301 SGTC_1171 0368-0077 21.4 µM 0.582669957413325 0.325428104921006 no 1090 0.280057750573791 1335 3239779 SGTC_2822 7994718 71.43 µM 0.582625430075292 0.325443405469403 no 1091 0.280072741208263 1371 1018011 SGTC_2170 morpholine 200 µM 0.581584911783248 0.32580103358671 no 1092 0.280423154204359 1435 121171 Reacts with secondary amines. SGTC_1911 st060208 74.3 µM 0.58067055015332 0.326115433809002 no 1093 0.280731256813314 1433 688783 SGTC_1579 chlormadinone acetate 49.4 µM 0.580414347450864 0.326203550445733 no 1094 0.280817616038629 1412 45114258 A steroidal progestin. SGTC_2618 avocadyne 43.43 µM 0.579557553844998 0.326498300745539 no 1095 0.281106512006725 1347 3015189 SGTC_1429 4049-0205 9.46 µM 0.579494839024893 0.326519879875276 no 1096 0.281127663995765 1386 22774478 SGTC_1128 3448-9350 235 µM 0.578908972015488 0.326721495033348 no 1097 0.281325297998875 1368 619386 SGTC_3191 9110352 49.47 µM 0.578449772987373 0.326879555161426 no 1098 0.281480249207051 1403 17122424 SGTC_1376 2910-0861 41.3 µM 0.577772595359395 0.327112702021428 no 1099 0.28170882978733 1410 1112859 SGTC_867 0518-0118 155 µM 0.577676900908 0.327145654302368 no 1100 0.281741138561577 1395 6848158 SGTC_3184 9108758 49.47 µM 0.5768868703398 0.327417751936607 no 1101 0.282007940318812 1375 902885 SGTC_1601 4'-hydroxyflavanone 55.5 µM 0.576446288361146 0.327569534407829 no 1102 0.282156782390345 1452 165506 SGTC_2686 alizarin 95.37 µM 0.575942288369278 0.32774319962017 no 1103 0.282327095366851 1340 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1 SGTC_592 k241-0073 46.5 µM 0.574646240461868 0.328189954878331 no 1104 0.282765286203877 1432 4230158 SGTC_2627 acetyl isogambogic acid 100 µM 0.574096136831227 0.328379653165071 no 1105 0.282951373706444 1315 6857789 A caspase activator and apoptosis inducer. SGTC_2061 5245884 80.95 µM 0.568872471139479 0.330183186718479 no 1106 0.284721344315788 1369 573863 SGTC_625 k213-0058 121 µM 0.567697974094556 0.330589241786899 no 1107 0.285120033716264 1445 3655420 SGTC_2651 TUB2.036 5 µM 0.565072390961967 0.331497697033314 no 1108 0.286012263299981 1465 15992207 YFL037W TUB2 SGTC_1569 carminic acid 40.6 µM 0.565018696953546 0.331516285601937 no 1109 0.286030523515056 1394 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_1011 4112-3381 17.4 µM 0.564211754449504 0.331795694592151 no 1110 0.286305014574739 1432 2877139 SGTC_1530 rhein 70.4 µM 0.563798274241244 0.331938901026498 no 1111 0.286445713212642 1409 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death. SGTC_3159 9100096 49.47 µM 0.562357564480521 0.332438074089941 no 1112 0.286936212681735 1331 25236875 SGTC_1818 st052136 56.3 µM 0.562117810774052 0.332521172159709 no 1113 0.287017877070583 1310 674169 SGTC_2624 nerol 100 µM 0.561582542025475 0.332706724744243 no 1114 0.287200238866378 1412 637566 A natural product oil. SGTC_16 erodoxin 22.806 µM 0.561204774970633 0.332837703548763 no 1115 0.287328974093407 1417 3967339 Erodoxin inhibits Ero1. YML130C ERO1 SGTC_301 4119-0100 24.5 µM 0.561118210223675 0.332867720016635 no 1116 0.287358477419618 1400 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1 SGTC_2711 st079103 59.1 µM 0.560957231714055 0.3329235424266 no 1117 0.287413346537769 1423 54693780 SGTC_2086 5274770 176.623 µM 0.560397944768876 0.333117514761891 no 1118 0.287604016586199 1394 689278 SGTC_2387 9077560 195.08 µM 0.560374338135836 0.333125703015303 no 1119 0.28761206578764 1353 5303272 SGTC_2075 5212009 200 µM 0.55958084349764 0.333400982726631 no 1120 0.287882687183401 1406 780898 SGTC_2478 5763493 32.33 µM 0.559418211718279 0.333457414143547 no 1121 0.287938167606878 1404 1365576 YLR208W SEC13 SGTC_2663 amphotericin b 100 µM 0.556442972382684 0.334490453151604 no 1122 0.28895403459634 1375 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_448 monastrol 171 µM 0.54936477906224 0.336953117724083 no 1123 0.291377569949748 1419 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity SGTC_1126 isoteolin 1.0172 µM 0.549134583223989 0.337033326276276 no 1124 0.291456546760644 1368 133323 SGTC_1476 4112-3294 3.34 µM 0.547999792344034 0.337428836686685 no 1125 0.291846022709927 1476 704369 SGTC_1755 st041960 45.185 µM 0.54704361469848 0.337762234263358 no 1126 0.29217438421455 1422 2257073 SGTC_2750 bromebric acid 70.15 µM 0.546440165077546 0.337972709096512 no 1127 0.2923817036288 1472 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2 SGTC_235 0330-0087 5 mM 0.545761543672568 0.33820946332542 no 1128 0.292614930523437 1397 46494818 YHR062C RPP1 SGTC_1284 0929-0043 16 µM 0.545145000933118 0.338424615324823 no 1129 0.292826897282539 1400 1239883 SGTC_420 mitomycin C 81.9 mM 0.544207476870468 0.338751879745445 no 1130 0.29314935362755 1386 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_1998 st075797 76.8 µM 0.544022990197795 0.338816293424409 no 1131 0.29321282620733 1414 24208315 SGTC_1932 st074806 40.9 µM 0.543885629555577 0.338864256071241 no 1132 0.293260089229273 1505 17251235 SGTC_2913 7966556 36.57 µM 0.542382629514184 0.339389233856029 no 1133 0.293777471744887 1458 2976516 SGTC_917 harmaline 728.087 nM 0.540500378231469 0.340047118788912 no 1134 0.294426000109501 1466 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7 SGTC_2874 9043904 71.43 µM 0.538838191862365 0.340628491885475 no 1135 0.29499925417926 1409 4463428 SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM 0.537952030748236 0.340938594132829 no 1136 0.295305083011623 1378 2333 A French combination drug. SGTC_2668 2',4'-dihydroxychalcone 15.08 µM 0.534124613580343 0.342279188806302 no 1137 0.296627660793631 1453 5357218 A potent inhibitor of glutathione S-transferases. SGTC_3175 9106517 49.47 µM 0.534111280193239 0.342283862458642 no 1138 0.296632272932325 1390 41468073 SGTC_601 0986-0029 62.9 µM 0.531421321154506 0.343227246817675 no 1139 0.297563424933532 1433 24747981 SGTC_3136 9095672 49.47 µM 0.531299757606987 0.343269903000388 no 1140 0.297605536675392 1356 17217380 SGTC_2122 5258151 111.688 µM 0.530252494307664 0.343637466327015 no 1141 0.297968439626085 1397 2173356 SGTC_2815 7968870 71.43 µM 0.528602835328914 0.344216755370586 no 1142 0.298540496504965 1422 2977326 YHR190W ERG9 SGTC_3 0833-0587 95.581 µM 0.528326383595546 0.344313869104935 no 1143 0.298636411303836 1381 5382644 SGTC_3115 9123671 49.47 µM 0.528112098975499 0.344389151440872 no 1144 0.298710766890753 1504 3286988 SGTC_2814 7977482 42.97 µM 0.527822092794703 0.344491046045042 no 1145 0.298811410843969 1545 6456762 SGTC_2439 5492030 7.2 µM 0.525769944357734 0.345212397112031 no 1146 0.299524029803395 1449 5722370 SGTC_258 haloperidol 50.781 µM 0.524447634936809 0.34567750063745 no 1147 0.29998361615153 1388 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_840 0245-0196 390 µM 0.523868477711612 0.345881284377353 no 1148 0.300185010437729 1521 3827528 SGTC_2767 sibutramine 71.45 µM 0.522984859173552 0.346192282670335 no 1149 0.300492394860607 1536 64765 A serotonin-norepinephrine reuptake inhibitor.  SGTC_2664 lyso-paf C-16 73.48 µM 0.522067215926182 0.346515366120912 no 1150 0.300811765851211 1459 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_1190 1486-1332 13 µM 0.521633165987598 0.34666822516468 no 1151 0.300962883285265 1415 4150046 SGTC_905 2-aminofluorene 215 µM 0.520784838879722 0.34696705195459 no 1152 0.30125833290617 1464 1539 An established DNA mutagen. YPR165W RHO1 SGTC_679 0422-0091 41.4 µM 0.519270416349402 0.34750075023487 no 1153 0.301786090200137 1429 627384 YHR062C RPP1 SGTC_2983 9022671 12.99 µM 0.518345470604282 0.347826859595352 no 1154 0.302108626498029 1582 6405161 SGTC_310 1273-0058 1.06 µM 0.518234408437721 0.347866024509242 no 1155 0.302147365207287 1435 2734232 SGTC_1313 1220-0047 237 µM 0.516943938229309 0.348321214271608 no 1156 0.302597647216405 1508 3528706 SGTC_1677 st019204 53.9 µM 0.512895575579661 0.349750615817638 no 1157 0.304012184263385 1416 3945625 SGTC_1768 st044301 37.178 µM 0.511281061483554 0.350321266664297 no 1158 0.304577132146593 1431 3931349 SGTC_1702 st027038 51 µM 0.51080617488008 0.350489179979409 no 1159 0.304743392460477 1487 5521182 SGTC_2645 abamectin 100 µM 0.509450566696966 0.350968664887844 no 1160 0.305218219879219 1485 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels. SGTC_898 1000-0849 28.3 µM 0.509115010823548 0.351087389243508 no 1161 0.305335805348132 1472 6751807 SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM 0.499505684008051 0.354493431485826 no 1162 0.308711591748542 1567 1377 SGTC_2628 lathosterol 100 µM 0.499401972400735 0.354530256373086 no 1163 0.308748114976619 1518 6710616 SGTC_2937 9044753 11.33 µM 0.499038393172106 0.354659363210848 no 1164 0.308876168496538 1433 6465530 YGL099W LSG1 SGTC_2696 st077691 74.316 µM 0.497235658757151 0.355299759868122 no 1165 0.309511439082196 1493 757133 SGTC_1828 st055811 49 µM 0.495406710077963 0.355949886616342 no 1166 0.310156529565536 1510 5877589 SGTC_2128 5255449 168.493 µM 0.495058752116306 0.356073620908637 no 1167 0.31027932445605 1440 736008 SGTC_1427 4048-4900 550 nM 0.494264766976499 0.356356019773723 no 1168 0.310559602202815 1561 24132586 SGTC_2903 5923464 63.88 µM 0.492425087582533 0.357010646117557 no 1169 0.311209433862648 1505 2876576 SGTC_962 1254-0300 21.5 µM 0.491340623628101 0.357396736187968 no 1170 0.311592776096248 1507 7340576 SGTC_298 1391-0729 10 µM 0.490935459493785 0.357541019917745 no 1171 0.311736048168905 1483 3237558 SGTC_2202 7226349 200 µM 0.490664736163613 0.357637439041022 no 1172 0.311831795856179 1462 844334 SGTC_3166 9102297 49.47 µM 0.489949697391658 0.357892146442851 no 1173 0.312084747321826 1438 25237072 SGTC_2544 sphondin 68.51 µM 0.489132859951714 0.35818319347061 no 1174 0.312373819444684 1548 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31 SGTC_3009 9080819 71.4286 µM 0.487731181627539 0.358682816927308 no 1175 0.312870131109359 1493 17027216 SGTC_2591 skatole 100 µM 0.487068136057621 0.35891924160169 no 1176 0.313105023138908 1504 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite. SGTC_3275 9138069 49.47 µM 0.486493570628456 0.359124160297768 no 1177 0.313308631354685 1536 17617007 SGTC_293 4049-0273 38.5 µM 0.485467962674468 0.359490043990954 no 1178 0.313672216541858 1462 1380311 SGTC_202 3594-0513 34.79 µM 0.485449223558642 0.359496730334689 no 1179 0.313678861374714 1506 708429 SGTC_523 1934-0222 13.7 µM 0.48388598536743 0.360054663971669 no 1180 0.314233393509538 1477 1361595 SGTC_1752 st044819 83.042 µM 0.483668439368976 0.36013233174464 no 1181 0.314310597533922 1431 441209 YML126C ERG13 SGTC_493 zm226600 134 µM 0.483494805084315 0.36019432640175 no 1182 0.314372223736596 1532 5240098 A potassium channel opener. YCR052W RSC6 SGTC_3168 9103419 49.47 µM 0.48091266619116 0.361116690395837 no 1183 0.315289285106866 1498 16649256 SGTC_3050 9093513 49.47 µM 0.480868065944058 0.361132629132914 no 1184 0.315305135163826 1476 25236664 SGTC_2352 9027995 87.8 µM 0.479303572828034 0.361691882550801 no 1185 0.315861340399092 1541 2997347 SGTC_2603 homopterocarpin 100 µM 0.479216094875696 0.361723161698185 no 1186 0.315892452699756 1517 101795 A weak amylase inhibitor. SGTC_2622 2-methoxyxanthone 59.94 µM 0.47894654695838 0.361819548695563 no 1187 0.315988327980104 1653 71034 A hepatoprotective. SGTC_2429 5902844 64.44 µM 0.477946056986369 0.36217738813393 no 1188 0.316344299644644 1611 1927790 YGL093W | YPR107C SPC105 | YTH1 SGTC_64 000l-0018 272.079 µM 0.476014495187949 0.362868579237063 no 1189 0.317032025595581 1527 6811119 SGTC_246 cycloheximide 667 µM 0.475583976200191 0.363022697378139 no 1190 0.317185396689266 1466 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells. SGTC_1802 st050112 57.9 µM 0.475425227936686 0.363079532033036 no 1191 0.317241958206807 1503 4662563 SGTC_97 0535-0701 19.132 µM 0.475057495004794 0.36321119843517 no 1192 0.317372996714616 1444 2832013 YGL099W LSG1 SGTC_1708 st033234 31.827 µM 0.47383827545543 0.363647854328888 no 1193 0.317807618954739 1583 674664 SGTC_732 3970-1727 52.7 µM 0.473321005233181 0.363833165003996 no 1194 0.317992089173003 1641 1275699 SGTC_957 1187-1561 14.1 µM 0.472410362609789 0.364159477668105 no 1195 0.318316954589113 1493 1538454 SGTC_1197 1601-0112 267 µM 0.472028085473153 0.364296489281537 no 1196 0.318453370965328 1476 7350313 SGTC_366 0181-0206 4.31 µM 0.47202640715236 0.364297090845272 no 1197 0.318453969931817 1681 274874 SGTC_2633 5,7-dihydroxyisoflavone 100 µM 0.471489518266064 0.364489546107169 no 1198 0.318645601541082 1587 5377381 SGTC_2932 9016711 44.54 µM 0.46898572344546 0.365387516522452 no 1199 0.319539920368236 1642 7117328 SGTC_514 4466-0038 2.65 nM 0.467787061916498 0.365817670698955 no 1200 0.319968436907083 1565 5722064 SGTC_2304 7443016 91.4 µM 0.467210377895722 0.366024680888334 no 1201 0.320174684720101 1502 939854 SGTC_355 1311-2252 105 µM 0.466831452241063 0.36616072370773 no 1202 0.32031023562051 1499 5338538 SGTC_232 clozapine 119 µM 0.466194719278026 0.366389363023798 no 1203 0.320538064445947 1550 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_680 0417-1641 114 µM 0.464004879083983 0.367176056754085 no 1204 0.321322124994764 1503 2835990 SGTC_1422 4031-0024 15.5 µM 0.4628716665386 0.367583379363961 no 1205 0.321728178828849 1514 782427 SGTC_271 rotenone 740 µM 0.462868434604502 0.367584541265628 no 1206 0.321729337203517 1568 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria. SGTC_2357 9067248 200 µM 0.461582099625363 0.368047083330812 no 1207 0.322190516854776 1547 9150235 SGTC_1473 k844-0725 134 µM 0.460907149460493 0.368289859416051 no 1208 0.322432611079403 1577 54682906 SGTC_372 0155-0182 15.9 µM 0.459856731576223 0.368667793900787 no 1209 0.322809529590815 1583 771486 SGTC_745 0469-0705 296 µM 0.459396455107079 0.368833438860593 no 1210 0.322974746710538 1660 3486736 SGTC_3342 9147791 14.508 µM 0.458066437707771 0.369312224289697 no 1211 0.323452355250043 1508 1838168 SGTC_2531 methyl deoxycholate 70.07 µM 0.45777123956957 0.36941851851957 no 1212 0.323558400237955 1505 16667744 Haematoxylin. SGTC_3065 9113888 49.47 µM 0.457667395384206 0.369455912855935 no 1213 0.323595707930419 1605 16648368 SGTC_2857 9024691 58.44 µM 0.456501952019987 0.369875674150271 no 1214 0.324014533732355 1544 16478292 SGTC_2510 benzyl isothiocyanate 8.31 µM 0.455835958306857 0.370115616806185 no 1215 0.324253972238623 1532 2346 DNA damaging agent; causes G2/M arrest. SGTC_1531 st059297 52.4 µM 0.454847061314529 0.370471987548073 no 1216 0.324609635241737 1546 7566702 SGTC_3197 9113331 49.47 µM 0.454790640089282 0.370492323530939 no 1217 0.324629932316901 1637 16610459 YLR208W | YDL195W SEC13 | SEC31 SGTC_2030 5175110 200 µM 0.454422893231694 0.370624879920841 no 1218 0.324762239004773 1604 2831986 SGTC_3256 9138902 49.47 µM 0.452953233163428 0.371154780231573 no 1219 0.325291208821463 1598 17228773 SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM 0.452090104300434 0.371466103755712 no 1220 0.325602036139816 1561 616764 SGTC_2943 9068529 45.32 µM 0.451616524890583 0.371636955722462 no 1221 0.325772631656873 1531 3270634 SGTC_2450 5739737 12.93 µM 0.450889264901977 0.371899376573089 no 1222 0.326034680495592 1548 2262825 SGTC_3015 9080845 49.47 µM 0.45065902955178 0.371982465953716 no 1223 0.326117657610569 1663 5296973 SGTC_1125 tnp00248 1.32998 µM 0.449524165811973 0.372392112727258 no 1224 0.326526789703919 1737 24207736 SGTC_18 0111-0177 500 nM 0.449109680378553 0.372541763741943 no 1225 0.326676268783005 1584 721752 SGTC_3341 9147222 25.867 µM 0.449061130740427 0.372559293971176 no 1226 0.326693779434578 1561 1939759 SGTC_1383 3049-0032 20.7 µM 0.447901070981962 0.372978245021244 no 1227 0.32711229771583 1659 712864 SGTC_2735 sertaconazole 140 nM 0.447358433145234 0.373174268170363 no 1228 0.327308141513255 1622 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C SGTC_2589 lobaric acid 100 µM 0.445526112780292 0.373836420138853 no 1229 0.327969796601139 1515 73157 A novel microtubule depolymerizer. SGTC_374 0880-0231 82.3 µM 0.444789216317538 0.374102820114411 no 1230 0.328236044060079 1558 6833587 SGTC_970 1315-0089 19.5 µM 0.444172054743923 0.37432598027241 no 1231 0.328459097368859 1483 6811083 YLR033W RSC58 SGTC_2446 5162541 200 µM 0.44266519613992 0.374871023792059 no 1232 0.329003960005577 1517 1549321 SGTC_79 0052-0007 94.094 µM 0.442233113127488 0.375027358049762 no 1233 0.329160263338567 1652 2801472 SGTC_693 4161-2696 114 µM 0.441925555417897 0.375138649655886 no 1234 0.329271538619307 1651 805759 SGTC_3308 9128332 17.569 µM 0.440710226126996 0.375578525485301 no 1235 0.329711396210108 1687 17332805 YDL196W YDL196W SGTC_1496 4469-0713 57.4 µM 0.439169814620513 0.376136293880133 no 1236 0.330269247626476 1658 746691 SGTC_2040 5100729 123 µM 0.437869061383645 0.376607485899751 no 1237 0.330740602166489 1600 11840 YJR013W | YDR381W GPI14 | YRA1 SGTC_1163 k060-0048 49.9 µM 0.435402154885247 0.377501616304498 no 1238 0.331635273252712 1568 6809982 SGTC_576 1073-0113 22.7 µM 0.435022766545497 0.377639184034135 no 1239 0.331772951144941 1656 5439563 SGTC_2569 tetrandrine 100 µM 0.43397648005187 0.378018652090374 no 1240 0.332152760325462 1506 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_2099 5377090 177.372 µM 0.431975392980293 0.378744735610209 no 1241 0.332879648827161 1554 2243829 SGTC_3276 9139060 49.47 µM 0.43183127251532 0.37879704549396 no 1242 0.332932024421913 1609 4870619 SGTC_3006 9075424 71.4286 µM 0.430765419680217 0.379183975716387 no 1243 0.333319472883819 1528 7465181 SGTC_767 0929-0023 86 µM 0.430535894589203 0.37926731470292 no 1244 0.33340293090986 1573 1204563 SGTC_1893 st059353 36.1 µM 0.429913513959657 0.379493325067116 no 1245 0.333629277329452 1543 3112488 SGTC_1944 st076371 56.9 µM 0.429736786841374 0.37955750899742 no 1246 0.333693560217824 1547 24208455 SGTC_1314 1222-0010 41.1 µM 0.428081542329134 0.380158823243367 no 1247 0.334295877200688 1603 3526027 SGTC_1786 berberine 21.6 µM 0.427984172716583 0.380194204539383 no 1248 0.334331321753355 1523 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_2916 7875993 68.79 µM 0.426682265279279 0.380667376189705 no 1249 0.334805384787641 1730 1299250 SGTC_2227 7312221 64.1025 µM 0.426580638305918 0.38070431951959 no 1250 0.334842401268954 1621 887188 YOR168W | YOR169C GLN4 | YOR169C SGTC_1575 cyproterone acetate 48 µM 0.425711036750226 0.381020480601927 no 1251 0.335159209432497 1518 9880 An androgen receptor antagonist and liver toxin. SGTC_1609 st001574 46.4 µM 0.425119627938549 0.38123554453549 no 1252 0.335374735067707 1566 3960012 SGTC_706 4262-0057 46.9 µM 0.425037085933015 0.38126556359202 no 1253 0.335404819955637 1543 883298 SGTC_710 3448-4187 58 µM 0.424373381925881 0.381506966865469 no 1254 0.335646764963861 1592 3946412 SGTC_1158 4092-0494 91.8 µM 0.42331227031974 0.381893011479061 no 1255 0.336033721501291 1669 1148199 SGTC_2063 5246145 200 µM 0.422194592100326 0.38229976271346 no 1256 0.336441494231939 1640 711240 SGTC_673 1082-0474 110 µM 0.421548571017074 0.382534925321543 no 1257 0.336677275790412 1579 3098046 SGTC_471 1-acyl-paf 4 µM 0.419772083953084 0.38318181980501 no 1258 0.337325980056591 1532 16759367 SGTC_2223 6903751 107.57 µM 0.41959319310724 0.383246979659301 no 1259 0.337391330911843 1646 5598863 SGTC_875 0709-0210 25.7 µM 0.418164889211804 0.383767348606144 no 1260 0.33791328232397 1648 6251364 SGTC_3212 9128307 49.47 µM 0.416380158791298 0.384417867778353 no 1261 0.338565922428297 1490 27243542 SGTC_3258 9138477 49.47 µM 0.414838649302145 0.38497999716044 no 1262 0.339130012082163 1642 4970355 SGTC_581 0958-0271 211 µM 0.413697297806543 0.385396360156373 no 1263 0.339547903154699 1543 4591145 SGTC_2882 9058044 58.44 µM 0.41347840406122 0.385476227319506 no 1264 0.339628070834674 1523 18076804 SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM 0.412926770359178 0.385677521936855 no 1265 0.339830133426513 1550 6708514 SGTC_462 ag-879 158 µM 0.408522273145774 0.387285850984644 no 1266 0.341445140911532 1687 6809654 Ag-879 is a 5-Lipoxygenase inhibitor. SGTC_294 k038-0071 157 µM 0.407534379276579 0.387646853349139 no 1267 0.341807774580223 1625 24152826 SGTC_2053 5265679 138 µM 0.407391933992727 0.387698914618143 no 1268 0.341860075099879 1559 764595 SGTC_2260 7964312 200 µM 0.40732248603112 0.387724297370118 no 1269 0.341885574864883 1719 231951 SGTC_1667 st014849 34.6 µM 0.40665524185189 0.387968194961388 no 1270 0.342130609005025 1626 5348460 SGTC_973 1325-0077 65.9 µM 0.405984575212673 0.388213388105622 no 1271 0.342376966994223 1732 2835149 SGTC_1388 3346-4487 254 µM 0.405042849247863 0.388557754696161 no 1272 0.342723007236317 1671 3345614 SGTC_2608 thymoquinone 42.66 µM 0.402789881475554 0.389381965987916 no 1273 0.343551402747367 1577 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC). SGTC_661 1304-0007 33.6 µM 0.401726995696937 0.389770978389486 no 1274 0.34394247738165 1597 3117130 SGTC_3353 9151644 39.2805 µM 0.401496601905081 0.389855316273795 no 1275 0.344027269740417 1617 4909158 SGTC_2303 7774051 200 µM 0.400342325868493 0.39027792822425 no 1276 0.344452198627419 1699 2953184 SGTC_1448 4255-0083 152 µM 0.399233387721762 0.390684062898729 no 1277 0.344860622063765 1770 5399660 SGTC_328 k915-0120 63.5 µM 0.398090523234618 0.391102747485053 no 1278 0.345281729856848 1719 6624543 SGTC_2467 5474540 200 µM 0.398090053226679 0.391102919696892 no 1279 0.345281903078693 1592 5413519 SGTC_1840 st055363 71 µM 0.395271553283179 0.392136006464839 no 1280 0.346321245438231 1566 676033 SGTC_2884 9058502 51.95 µM 0.390995272142632 0.393704875848574 no 1281 0.347900365267938 1598 6471554 SGTC_2140 5586273 200 µM 0.389665412157749 0.394193124197618 no 1282 0.348391987921285 1638 854421 SGTC_2270 7924575 90.91 µM 0.389497559889039 0.394254761764703 no 1283 0.348454057676598 1796 1262135 SGTC_2958 9077254 16.72 µM 0.388603794984453 0.394583008583922 no 1284 0.348784629513548 1627 16457351 SGTC_2962 9082311 13.18 µM 0.388350165750669 0.394676170874425 no 1285 0.3488784588698 1573 16459453 SGTC_2709 st078560 56 µM 0.387705649049651 0.394912939807603 no 1286 0.349116937417328 1759 17250903 SGTC_1036 k216-0215 33.5 µM 0.387321878877868 0.395053939629889 no 1287 0.349258965082727 1613 622330 SGTC_1766 st045414 44.774 µM 0.386761721742915 0.395259769911887 no 1288 0.349466308848613 1640 253960 SGTC_641 4092-0595 30 µM 0.385326428971815 0.395787302887674 no 1289 0.349997791474676 1696 786260 SGTC_2404 5161160 200 µM 0.384949074452076 0.395926028947071 no 1290 0.350137573050849 1700 2831543 SGTC_314 1671-0008 2.74 µM 0.384157462063909 0.396217090583257 no 1291 0.350430872089892 1647 3913060 SGTC_3023 9089636 49.47 µM 0.383846078301463 0.39633159665668 no 1292 0.350546266844371 1719 17249241 SGTC_1966 st070145 16.1 µM 0.383277950925458 0.39654053885735 no 1293 0.350756842962255 1600 3748532 SGTC_1172 0370-0043 85 µM 0.382928220398761 0.396669175261047 no 1294 0.350886493208274 1697 376585 SGTC_113 0099-0221 2.5 µM 0.382399641674018 0.396863616192881 no 1295 0.351082478059749 1754 89219 SGTC_1842 st055362 61.2 µM 0.381588804799766 0.397161937345523 no 1296 0.351383194734779 1715 676032 SGTC_717 1532-0246 73.2 µM 0.381291917608802 0.397271182426777 no 1297 0.351493325157806 1638 9561992 SGTC_177 1327-0068 8.361 µM 0.380992024846412 0.397381541645615 no 1298 0.351604583156243 1625 15389900 YOR207C | YLR033W RET1 | RSC58 SGTC_1346 1488-2224 62.4 µM 0.380759744264859 0.397467025525269 no 1299 0.351690766272322 1765 3722427 SGTC_2931 9014674 55.67 µM 0.378742378941604 0.39820966283332 no 1300 0.352439589939091 1587 2996810 SGTC_3321 9137793 26.8275 µM 0.378160836475361 0.398423810236566 no 1301 0.352655558456239 1649 4904192 SGTC_1150 3909-7983 10.9 µM 0.377605844811307 0.398628209093884 no 1302 0.352861711049825 1619 23965914 SGTC_1038 k292-0204 154 µM 0.376399130137192 0.399072728063926 no 1303 0.353310096291567 1607 4454212 SGTC_2441 5730946 39.09 µM 0.375326670994333 0.399467901059332 no 1304 0.353708766496268 1758 1774275 SGTC_2691 st077356 60.2 µM 0.375047453082585 0.399570802436806 no 1305 0.353812587813804 1754 2839272 SGTC_3097 9117246 49.47 µM 0.374506447525405 0.39977020138904 no 1306 0.354013780306708 1641 16423892 SGTC_3129 9127257 49.47 µM 0.373416618635677 0.400171960019195 no 1307 0.354419196343473 1546 837894 SGTC_1578 josamycin 24.2 µM 0.372113371208274 0.400652532772124 no 1308 0.354904220639605 1608 5282165 A P450 substrate. SGTC_770 0389-1121 67.2 µM 0.371455994197249 0.400894997795125 no 1309 0.355148963281503 1791 6753108 SGTC_2124 5246320 200 µM 0.370683019877437 0.401180148230905 no 1310 0.35543681946207 1703 579342 SGTC_582 0987-0078 156 µM 0.370573926207636 0.401220397158058 no 1311 0.35547745266762 1678 1625765 SGTC_2222 6885208 172.143 µM 0.368113939539263 0.402128260123958 no 1312 0.356394138663533 1702 609514 SGTC_1462 k081-0014 26.5 µM 0.366940494861568 0.402561508616283 no 1313 0.356831702304666 1584 3270634 SGTC_433 pimozide 108 µM 0.366738400264443 0.402636136229212 no 1314 0.356907080026544 1561 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic SGTC_2126 5251174 33.877 µM 0.366291329704392 0.402801238888942 no 1315 0.357073849310009 1859 790722 SGTC_2320 7373003 200 µM 0.36543683868639 0.403116849674383 no 1316 0.357392673291229 1599 5415828 SGTC_1268 0828-0275 2.46 µM 0.365405737296373 0.403128338329452 no 1317 0.357404279586204 1728 745337 SGTC_853 0419-0306 21 µM 0.365202202293734 0.403203524924841 no 1318 0.35748023723736 1627 762713 SGTC_2710 st078562 53.7235 µM 0.363710904640525 0.403754524882359 no 1319 0.358036949779774 1608 17250908 SGTC_916 4466-0038 42 nM 0.362180521060247 0.404320164818837 no 1320 0.358608567402359 1794 5722064 YGL116W CDC20 SGTC_3214 9129694 49.47 µM 0.361715013520413 0.404492259235329 no 1321 0.358782503270903 1799 17158655 SGTC_2861 9024595 19.48 µM 0.360183373173374 0.405058624688517 no 1322 0.35935500387122 1703 16482810 SGTC_776 4476-4378 112 µM 0.360076368231507 0.4050982001078 no 1323 0.359395012282883 1670 2892008 SGTC_2087 5276107 200 µM 0.36006976817599 0.405100641148004 no 1324 0.359397480048715 1655 144405 SGTC_2836 9010338 19.48 µM 0.359807793322323 0.405197535912324 no 1325 0.359495437383266 1551 2994051 SGTC_3120 9124077 49.47 µM 0.359450290094917 0.405329772447794 no 1326 0.359629129474348 1697 18774327 YGL155W CDC43 SGTC_2428 5615643 7.78 µM 0.359268951095823 0.405396851893404 no 1327 0.359696949668527 1735 2253075 SGTC_2892 9047358 58.44 µM 0.358835939938726 0.405557039090307 no 1328 0.359858912297831 1672 6466771 SGTC_2560 caryophyllene 100 µM 0.358203521906443 0.405791022844742 no 1329 0.36009550589102 1676 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor. SGTC_439 amiodarone 34.4 µM 0.357945285639001 0.405886575489317 no 1330 0.360192129948862 1756 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1 SGTC_2802 7925815 54.55 µM 0.357779392124119 0.405947962405237 no 1331 0.360254206905094 1647 1262923 SGTC_852 0418-0143 439 µM 0.357613120743994 0.406009491466176 no 1332 0.360316428954774 1790 5369229 SGTC_415 dibenzyl ketone 100 µM 0.355010137078977 0.406973032582561 no 1333 0.361290998480478 1798 7593 SGTC_1211 1056-0033 32.3 µM 0.354929623969417 0.407002844966399 no 1334 0.361321157368748 1806 6741922 SGTC_2602 kawain 100 µM 0.353821613019258 0.407413173779552 no 1335 0.361736287538311 1708 5369129 SGTC_554 4483-2211 187 µM 0.353801587969751 0.407420590576359 no 1336 0.361743791672603 1707 747107 SGTC_352 k048-0007 5.11 µM 0.352963882563084 0.407730886218301 no 1337 0.362057758789679 1698 6811911 SGTC_3220 9131269 49.47 µM 0.35226628466161 0.407989328628033 no 1338 0.362319285289162 1695 17722206 SGTC_129 0088-0017 176.636 µM 0.351256627744885 0.408363451906128 no 1339 0.362697915198033 1805 182446 SGTC_947 3447-0010 211 µM 0.350643501903828 0.408590683385469 no 1340 0.36292790815375 1678 748350 SGTC_1223 0764-0573 147 µM 0.350072369251914 0.408802379357055 no 1341 0.363142193305126 1696 1609797 SGTC_2754 granisetron 64.02 µM 0.350013175647774 0.408824321575284 no 1342 0.363164404801139 1827 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients. SGTC_668 1682-0499 62.6 µM 0.349869767645615 0.408877482045055 no 1343 0.363218218371843 1687 682214 SGTC_639 0833-0042 114 µM 0.349525971505017 0.409004931997427 no 1344 0.363347238191027 1663 5978911 YPR085C | YHR062C ASA1 | RPP1 SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM 0.349354923208347 0.409068345535841 no 1345 0.363411434974379 1673 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_1910 st062352 60.4 µM 0.348184782674784 0.409502220979117 no 1346 0.363850707648694 1614 2245730 SGTC_2849 9019321 12.99 µM 0.348170829043983 0.40950739550431 no 1347 0.363855946945654 1725 16489627 SGTC_2178 5812956 200 µM 0.346700907982361 0.41005258502763 no 1348 0.364408014005996 1714 5403383 SGTC_2460 5552655 174.22 µM 0.345694648427203 0.410425904169368 no 1349 0.364786103265252 1658 5401989 SGTC_3224 9130643 49.47 µM 0.345207712960154 0.410606584868651 no 1350 0.3649691103382 1773 17644395 SGTC_42 0133-0086 60.653 µM 0.34121482102113 0.412088886737699 no 1351 0.366470933271281 1620 162923 Model of phenazepam hydroxylation. SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM 0.339980417178993 0.412547395820379 no 1352 0.366935637648362 1715 521171 SGTC_2865 9030313 51.95 µM 0.337801138871962 0.413357161714527 no 1353 0.367756525796063 1655 42562754 SGTC_854 0422-0053 192 µM 0.33607756551518 0.41399786021609 no 1354 0.368406187804918 1682 3596728 SGTC_2636 apigenin dimethyl ether 100 µM 0.335859425291962 0.414078965153799 no 1355 0.368488437701465 1753 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_2261 9010538 184.68 µM 0.334069691388926 0.41474452959128 no 1356 0.369163485128647 1662 6457250 SGTC_2198 6589944 200 µM 0.333494698247957 0.414958409512392 no 1357 0.369380445407439 1774 5290268 SGTC_1517 deoxycholic acid methyl ester 49.2 µM 0.330949938293532 0.415905284467933 no 1358 0.370341150029408 1688 229346 A bile salt which induces apoptosis. SGTC_1463 k081-0032 34.1 µM 0.329775172318232 0.416342566044801 no 1359 0.370784924259968 1651 977755 SGTC_2190 6049624 200 µM 0.327665706624808 0.417128029258589 no 1360 0.37158221763187 1796 2265554 SGTC_3156 9099931 49.47 µM 0.326366083365955 0.417612111158853 no 1361 0.372073697710371 1749 18111053 SGTC_920 mycophenolic acid 780.421 nM 0.325967494441595 0.417760602075541 no 1362 0.372224474374256 1699 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_612 0302-0167 22.4 µM 0.325491220871662 0.417938049122412 no 1363 0.372404662971893 1835 235821 SGTC_3279 9140807 49.47 µM 0.325163705159547 0.418060082588228 no 1364 0.372528588215981 1729 45595718 SGTC_305 1682-2595 20.8 µM 0.325150392406919 0.418065043131973 no 1365 0.372533625768404 1777 226033 SGTC_2288 7946289 167.31 µM 0.324166078368913 0.418431850283955 no 1366 0.37290615106142 1858 1246052 SGTC_1361 1608-0041 5.61 µM 0.324029373899313 0.418482799173168 no 1367 0.372957897894703 1716 X1361 SGTC_1827 berberine 7.24 µM 0.323481947678424 0.41868683515055 no 1368 0.373165138463778 1610 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_165 k038-0023 64.381 µM 0.323410397910477 0.418713504703172 no 1369 0.373192227958823 1696 46368543 SGTC_66 0109-0187 42.4 µM 0.321444048067962 0.419446590285952 no 1370 0.373936953609623 1643 759417 SGTC_1770 st043884 66.3 µM 0.320548064632154 0.419780719655543 no 1371 0.37427645027632 1737 670149 SGTC_447 ml7 120 µM 0.31938157034391 0.420215814332499 no 1372 0.374718592175156 1818 4216 Selective myosin light chain kinase inhibitor. SGTC_3243 9134147 49.47 µM 0.317739166932353 0.420828585169368 no 1373 0.375341399346424 1814 24282180 SGTC_3068 9116768 49.47 µM 0.317440870075062 0.42093989856491 no 1374 0.375454549859846 1744 41904888 SGTC_3260 9137109 49.47 µM 0.316870984268343 0.421152576514479 no 1375 0.375670749775532 1866 17478346 SGTC_1245 0418-0076 17.2 µM 0.316716598684871 0.421210196247681 no 1376 0.375729326391655 1763 6790114 SGTC_494 Boc-Gly-Val-Val-CHO 140 µM 0.315296148627482 0.421740415152465 no 1377 0.376268404470553 1751 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA. SGTC_2979 9012552 45.46 µM 0.314832593095087 0.421913479736246 no 1378 0.376444381745778 1805 17100905 SGTC_536 3852-0578 10.6 µM 0.311841039682321 0.423030712490934 no 1379 0.377580666484068 1875 2869208 SGTC_270 tamoxifen 5.46 µM 0.310914439776515 0.423376888762967 no 1380 0.377932833400431 1895 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  YIL048W NEO1 SGTC_2759 disulfiram 3.38 µM 0.310748065411119 0.423439052237234 no 1381 0.377996076997753 1721 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_3107 9121808 49.47 µM 0.309255025802892 0.423996990888367 no 1382 0.378563769685823 1884 662681 SGTC_2840 9008771 71.43 µM 0.309167035454953 0.424029877042811 no 1383 0.378597234108395 1921 2992978 SGTC_1272 0839-0021 27 µM 0.309051066243887 0.424073221029701 no 1384 0.378641340821597 1790 5027250 SGTC_2813 7971799 71.43 µM 0.308298404713817 0.424354553785553 no 1385 0.378927639910781 1786 2234054 SGTC_1021 4476-0760 85.3 µM 0.307495884135713 0.424654565509052 no 1386 0.379232977683052 1691 746768 SGTC_704 1310-0270 142 µM 0.306867132270021 0.424889646600717 no 1387 0.379472253731801 1713 5718033 SGTC_2417 cerulenin 830 nM 0.305376203760485 0.425447189510817 no 1388 0.380039821700411 1755 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1 SGTC_2214 7179297 48.276 µM 0.305044888538393 0.425571107392718 no 1389 0.3801659822096 1835 769744 SGTC_3247 9135149 49.47 µM 0.304790232384914 0.425666358395058 no 1390 0.380262960614372 1788 8934436 YOR116C RPO31 SGTC_1310 1188-0297 994 nM 0.304524864502474 0.425765620603328 no 1391 0.380364026279172 1819 1588352 SGTC_2615 purpurogallin-4-carboxylic acid 100 µM 0.302997936621378 0.426336866980336 no 1392 0.380945717035113 1749 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase. SGTC_2060 5238662 140 µM 0.300346981609858 0.427328995071129 no 1393 0.381956250142924 1755 790130 SGTC_557 1315-0110 16.2 µM 0.299531575486922 0.427634256082835 no 1394 0.382267241759557 1733 6833801 SGTC_2784 7567673 72.73 µM 0.299484359554788 0.427651933490772 no 1395 0.382285251996877 1758 3471247 SGTC_2376 9072922 81.32 µM 0.298991259687005 0.42783655627758 no 1396 0.382473357228576 1813 17087968 SGTC_545 4218-0007 221 µM 0.298451703496328 0.428038590997861 no 1397 0.382679216158188 1790 2840508 SGTC_656 4090-1979 187 µM 0.298204677153695 0.42813109535183 no 1398 0.382773476127052 1908 22330961 SGTC_849 0386-0493 241 µM 0.296646516820161 0.428714672996891 no 1399 0.383368196606481 1787 726119 SGTC_2358 9037157 4 µM 0.293542808038397 0.429877568063926 no 1400 0.384553641863208 1818 2388925 SGTC_174 3553-0389 74.3 µM 0.292543261967868 0.430252207217638 no 1401 0.38493564375656 1833 738071 SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM 0.292189097707074 0.430384966357564 no 1402 0.385071023438476 1885 279621 SGTC_384 k007-0144 5.16 µM 0.291745765114484 0.430551161503498 no 1403 0.385240507557694 1812 6824886 SGTC_1049 3226-0134 66 µM 0.290470989642703 0.431029113817994 no 1404 0.385727970710042 1811 5702385 SGTC_2655 perillic acid 100 µM 0.2899973509449 0.431206721230783 no 1405 0.385909132103686 1775 5702197 An apoptosis inducer. SGTC_2062 5245942 200 µM 0.289491773703232 0.43139632046819 no 1406 0.38610253708334 1835 1376160 SGTC_2697 mebhydrolin 72.4 µM 0.288843533427958 0.431639443658857 no 1407 0.386350558204279 1911 22530 H1 Histamine receptor antagonist. YIL048W NEO1 SGTC_2465 5809242 33.21 µM 0.288052151721947 0.431936287290626 no 1408 0.386653409156199 1849 2731748 SGTC_1696 st025591 34.7925 µM 0.285752218175556 0.432799199332007 no 1409 0.387533953546281 1811 2787147 SGTC_701 4424-0219 185 µM 0.285238560737535 0.432991962397024 no 1410 0.387730689841345 1929 2911779 SGTC_2992 9074591 71.4286 µM 0.285164545399099 0.433019739857468 no 1411 0.38775904088525 1855 17741321 SGTC_2765 myclobutanil 7.74 µM 0.284206867233864 0.433379179849397 no 1412 0.388125926540373 1800 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11 SGTC_244 nsc-207895 1.295 µM 0.284106730931167 0.433416766635751 no 1413 0.388164294441737 1776 42640 SGTC_279 1273-0055 2.93 µM 0.283610163854435 0.433603165079291 no 1414 0.388354573595036 1931 2847562 SGTC_1699 st031318 29.054 µM 0.282385354800463 0.434062989788515 no 1415 0.388824021709362 1880 5340658 SGTC_843 0310-0051 143 µM 0.278552833229674 0.43550239030244 no 1416 0.390294007018142 1831 2065037 SGTC_500 h-89 112 µM 0.278065290323166 0.435685561079231 no 1417 0.390481119845664 1939 449241 Protein kinase A inhibitor; also known to inhibit several other kinases. SGTC_330 1488-0319 80.1 µM 0.276986408598492 0.436090947945452 no 1418 0.390895271187508 1841 6846614 SGTC_1659 st012954 42.1 µM 0.275925371110416 0.436489695383727 no 1419 0.391302693375495 1876 24207262 SGTC_2783 7738165 71.43 µM 0.273961712152635 0.437227826068918 no 1420 0.392057022796 1721 17201110 SGTC_1527 coumarin 137 µM 0.272259548282799 0.437867838841107 no 1421 0.392711228760402 1891 323 A hepatotoxic, DNA x-linker. SGTC_689 0833-0039 98 µM 0.272088413803118 0.437932194342467 no 1422 0.392777019020596 1926 5374726 SGTC_193 1273-0060 1.558 µM 0.271690210115597 0.438081946075348 no 1423 0.392930114720245 1919 2847393 YHR072W ERG7 SGTC_1082 camptothecin 424.86 nM 0.270862378882953 0.43839329540863 no 1424 0.393248440503709 1580 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_2482 5981709 142.65 µM 0.269737540499075 0.438816410926093 no 1425 0.393681088748155 1862 877755 SGTC_1359 1582-0056 520 nM 0.269526550673172 0.438895783970146 no 1426 0.393762256713909 1877 3661189 SGTC_2024 5144227 134 µM 0.269187112832566 0.43902348350382 no 1427 0.393892848425426 1898 3475211 SGTC_1362 1611-0397 101 µM 0.268792497348377 0.439171949334983 no 1428 0.394044683597192 1805 27816 SGTC_2646 retinol 96.75 µM 0.268755881541455 0.439185725701487 no 1429 0.394058772982722 1863 445354 A vitamin A analog and teratogen. SGTC_1375 2910-0797 186 µM 0.267606340162379 0.439618267630937 no 1430 0.394501175085184 1854 742508 SGTC_3014 9081533 49.47 µM 0.265430353543755 0.440437230656795 no 1431 0.395338977865705 1952 21367265 SGTC_213 1246-0773 967 nM 0.264711465181366 0.440707850535369 no 1432 0.395615872272626 1883 6251622 SGTC_2165 5727197 32.143 µM 0.264624713262085 0.440740509489201 no 1433 0.395649290096636 1871 1361712 SGTC_3226 9131256 49.47 µM 0.26451643960292 0.440781271163622 no 1434 0.395690999415375 1861 17178073 SGTC_1002 4049-0206 172 µM 0.263751224960671 0.441069368604782 no 1435 0.395985810416243 1802 4662749 SGTC_3292 9120825 59.784 µM 0.263577830853427 0.441134654495473 no 1436 0.396052621504201 1990 24824900 SGTC_1294 1000-1494 117 µM 0.263056565820852 0.441330929453072 no 1437 0.396253490331588 1797 712797 YDL207W GLE1 SGTC_1086 cerivastatin 2.18 µM 0.262560234881655 0.441517829224329 no 1438 0.396444776438644 1925 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7 SGTC_2734 clemastine 41.6 µM 0.262284484194426 0.441621672307139 no 1439 0.396551061619485 1883 26987 Clemastine is a selective histamine H1 antagonist. SGTC_127 0180-0333 59.125 µM 0.261593551024914 0.441881883756096 no 1440 0.39681740823524 1944 771601 SGTC_2682 pyrogallin 40.03 µM 0.260667882634002 0.44223053782641 no 1441 0.397174317956878 1896 822798 An ATP competetive kinase inhibitor. SGTC_2369 9071472 200 µM 0.26044240635562 0.442315470516046 no 1442 0.397261267842984 1870 17296037 SGTC_481 bay k-8644 50 µM 0.259827428016544 0.44254713480154 no 1443 0.397498446435128 1809 2303 A calcium channel antagonist. SGTC_2880 9042983 58.44 µM 0.259380600680217 0.442715468400185 no 1444 0.397670798036566 1837 6464714 SGTC_2461 5755302 26.15 µM 0.258717247816449 0.442965392887966 no 1445 0.3979267053568 1954 2788904 SGTC_1620 st003704 16.5 µM 0.257948422543409 0.443255083495244 no 1446 0.398223356618965 1964 2834414 SGTC_579 4491-1009 110 µM 0.257730995177752 0.443337014856116 no 1447 0.398307261656262 2032 1271041 SGTC_2723 salbutamol 83.58 µM 0.256414031226277 0.443833327170509 no 1448 0.398815577294861 1938 9884233 β2-adrenoceptor agonist SGTC_1860 st056228 74.6 µM 0.255823543333798 0.444055887666632 no 1449 0.39904354686784 1819 688679 SGTC_1006 4099-6547 255 µM 0.255404618153133 0.444213795250056 no 1450 0.399205302138548 1912 3146833 SGTC_3211 9128781 49.47 µM 0.254830618926498 0.444430170051595 no 1451 0.399426962654343 1749 17194361 SGTC_3267 9137951 49.47 µM 0.254676143234432 0.4444884040538 no 1452 0.399486621866553 1859 16643986 SGTC_402 epigallocatechin gallate 10 µM 0.254186566361005 0.444672971880669 no 1453 0.399675714173946 1827 65064 An antioxidant. SGTC_3332 9141069 11.198 µM 0.253738040267801 0.444842074316892 no 1454 0.39984897184108 1782 17332883 SGTC_1072 oxiconazole 14.9 nM 0.253056578942104 0.445099016744658 no 1455 0.400112245982252 1875 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_168 3970-0862 530.542 µM 0.252095264497074 0.445461515933832 no 1456 0.400483715085877 1872 3135186 SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM 0.251566906002622 0.445660772497733 no 1457 0.400687920624367 1828 6708784 An antioxidant flavonoid SGTC_820 1582-0060 59.9 µM 0.251374657620571 0.44573327734684 no 1458 0.400762229535631 1839 3848840 SGTC_2129 girgensonine 121.053 µM 0.251158567752205 0.445814775976914 no 1459 0.40084575807715 1898 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_515 4092-1064 102 µM 0.250799590405683 0.445950169901001 no 1460 0.400984529133361 2001 717353 SGTC_1290 0986-0249 10.2 µM 0.250218963638716 0.446169175707794 no 1461 0.401209010377234 1960 53329 SGTC_3042 9091578 49.47 µM 0.249964641933296 0.446265108136045 no 1462 0.401307346214566 1955 25236497 SGTC_225 nsc-122657 1.016 µM 0.249846474263588 0.446309683111458 no 1463 0.401353038963465 1914 275685 SGTC_1220 1838-0075 193 µM 0.249827358598312 0.446316893948799 no 1464 0.401360430683021 1895 5529645 SGTC_3313 9133968 57.047 µM 0.249067551432962 0.446603523796393 no 1465 0.401654264423591 1883 1494643 SGTC_1418 3966-3099 2.4 µM 0.248864681162676 0.446680059353749 no 1466 0.401732728124872 1938 740335 SGTC_1741 st038134 10.228 µM 0.24794120794271 0.447028477190219 no 1467 0.402089947904951 1954 1272587 SGTC_211 3455-0679 143.504 µM 0.247722990149999 0.44711081471153 no 1468 0.402174371312474 1856 748649 SGTC_3161 9100388 49.47 µM 0.247717722592418 0.447112802284502 no 1469 0.402176409264873 1909 25236368 SGTC_719 2810-4230 27.3 µM 0.24708946306253 0.447349868847398 no 1470 0.402419494107188 1887 721079 SGTC_2300 7976697 71.57 µM 0.246624432919312 0.447525354784218 no 1471 0.402599446891942 1802 2236109 SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM 0.246481592060473 0.447579259938648 no 1472 0.402654726185902 1895 6708739 YPR165W RHO1 SGTC_2196 6573537 42.6665 µM 0.244466213047826 0.448339924597363 no 1473 0.403434883154817 1987 2903087 SGTC_1328 1441-0025 69.2 µM 0.244410827114032 0.448360831609596 no 1474 0.403456328594713 1784 4562601 SGTC_1733 st037357 54.9 µM 0.243890487198163 0.448557255858244 no 1475 0.403657818436444 1748 1272339 YGL099W LSG1 SGTC_2984 9022109 38.96 µM 0.243238106440772 0.448803542303946 no 1476 0.403910474224782 2040 6459207 SGTC_2850 9015429 58.44 µM 0.243119438525707 0.4488483438774 no 1477 0.403956436569625 1830 6457570 SGTC_729 4092-0585 94.1 µM 0.242700334561449 0.449006576504814 no 1478 0.404118774129015 1808 2169061 SGTC_3302 9125395 16.351 µM 0.242393435819732 0.449122451216021 no 1479 0.404237660102649 1875 17599668 SGTC_2349 9023730 187.07 µM 0.241135413241398 0.449597483756508 no 1480 0.404725083318031 1967 4126287 SGTC_728 3030-5151 22.5 µM 0.240171017963331 0.449961690830978 no 1481 0.405098840258838 1880 3125388 SGTC_994 3910-0338 138 µM 0.238596441787917 0.450556425198676 no 1482 0.405709262248558 1955 3479481 SGTC_3297 9117502 71.43 µM 0.23806634916368 0.450756671937825 no 1483 0.405914816969964 1984 7453720 SGTC_620 0109-0052 432 µM 0.2380466474221 0.450764114670586 no 1484 0.405922457240825 1991 493037 SGTC_1457 k015-0032 57.3 µM 0.23727763035503 0.451054639976724 no 1485 0.406220707509114 1864 4302660 SGTC_2399 5884133 200 µM 0.237246623872674 0.451066354400094 no 1486 0.406232733991686 1836 722445 SGTC_2804 7954240 19.48 µM 0.236231823384093 0.451449775195148 no 1487 0.406626393366902 1969 828705 SGTC_371 0195-0006 7.36 µM 0.235309647069421 0.451798239209371 no 1488 0.406984204021773 1834 3928593 SGTC_591 4299-0174 154 µM 0.234345155821194 0.452162732556816 no 1489 0.407358516231427 1920 5509088 SGTC_2795 7780010 54.55 µM 0.234129744927996 0.452244144556226 no 1490 0.407442127241326 1905 953673 SGTC_309 k408-0051 1.48 µM 0.233928645071202 0.45232014968107 no 1491 0.407520187276926 1911 3640463 SGTC_2313 7726885 200 µM 0.233404259510959 0.452518347939102 no 1492 0.407723752949107 1891 726423 SGTC_1731 st035964 63 µM 0.23260984621382 0.452818629172228 no 1493 0.408032190424476 1836 6739575 SGTC_1012 4112-3522 18 µM 0.231605210857938 0.453198411111915 no 1494 0.408422329936889 2004 3112398 SGTC_1573 oleylamine 1.06 µM 0.231598392657878 0.453200988740264 no 1495 0.408424978023342 1857 5356789 An amine of the fatty acid oleic acid. SGTC_2830 7992007 71.43 µM 0.231401331100127 0.453275488939714 no 1496 0.40850151557778 1819 1952075 SGTC_588 3970-1144 52.9 µM 0.231354649941088 0.453293137248162 no 1497 0.408519646777867 1985 1888707 SGTC_775 4577-0580 57.3 µM 0.230187776943616 0.453734315872889 no 1498 0.408972929723595 1955 2006902 SGTC_2838 9002687 71.43 µM 0.22992418588459 0.453833983950849 no 1499 0.40907534106579 1816 6457060 SGTC_778 3456-2434 196 µM 0.229821179516963 0.453872933128683 no 1500 0.40911536315569 2029 5539063 SGTC_2545 solidagenone 89.61 µM 0.228890382295596 0.454224909951596 no 1501 0.409477057984406 1930 6708572 An anti ulcer agent SGTC_2670 beta-carotene 100 µM 0.228877918615239 0.454229623281334 no 1502 0.409481901720451 1968 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.) SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM 0.227600497026797 0.454712733691937 no 1503 0.409978416760732 1865 442882 SGTC_3079 9117512 49.47 µM 0.227513707614139 0.454745559177437 no 1504 0.410012155779324 1939 7185044 SGTC_2039 Aminomethylbenzodioxan 200 µM 0.227400312028045 0.454788448113596 no 1505 0.410056238839595 1891 15053 SGTC_1936 st074407 74.3 µM 0.226945901031022 0.454960322557527 no 1506 0.410232904622737 1828 809813 SGTC_476 mead acid 10 µM 0.226841831315634 0.454999686622963 no 1507 0.410273367383668 1902 5312531 An omega 9 fatty acid. SGTC_1071 trifluoperazine 6.31 µM 0.22625990534417 0.455219806552163 no 1508 0.410499640341448 1962 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. SGTC_1539 benzyladenosine 56 µM 0.225722899302824 0.455422947221028 no 1509 0.410708473310866 1902 92208 A nucleotide analog. SGTC_441 propafenone 146 µM 0.225125008333799 0.45564913338032 no 1510 0.41094101322511 1910 4932 Slows the influx of sodium ions into the cardiac muscle. SGTC_1107 amlodipine 47 µM 0.223640568845944 0.456210768782972 no 1511 0.411518496853234 1926 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.  SGTC_2507 purpurin 79.67 µM 0.220895651323692 0.457249533787448 no 1512 0.412586841765495 1804 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1 SGTC_827 3253-0474 693 µM 0.219952820991344 0.457606398850368 no 1513 0.412953949130431 2034 5402065 SGTC_268 camptothecin 39.6153 µM 0.218926644736071 0.45799484951918 no 1514 0.413353595198902 1940 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_109 0132-0036 33.701 µM 0.218821685462679 0.458034583265957 no 1515 0.413394476833025 2043 67274 A color developer. SGTC_1329 1447-1697 50.6 µM 0.218623871716782 0.458109469463782 no 1516 0.413471527833697 1936 2840515 SGTC_1207 2099-0101 141 µM 0.218602750025302 0.458117465574211 no 1517 0.413479755201398 2036 5837381 SGTC_1556 plumbagin 1.48 µM 0.217064172765516 0.458699975369905 no 1518 0.414079167141933 2007 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_3305 9127027 53.8275 µM 0.216408181498431 0.458948362601957 no 1519 0.414334794727378 1923 41905295 SGTC_324 1315-0088 19.6 µM 0.216015358501246 0.459097110396407 no 1520 0.414487887916849 1976 6787421 SGTC_1546 5-methoxyflavanone 78.7 µM 0.215644095992553 0.459237699281551 no 1521 0.414632590373167 2056 147795 SGTC_425 3825-7017 13.1 µM 0.215472068853761 0.459302843876402 no 1522 0.414699643220203 1966 3397440 SGTC_299 1273-0059 1.44 µM 0.214235086089511 0.459771306348304 no 1523 0.41518186822251 2023 2848077 SGTC_1178 0988-0033 191 µM 0.213534342326473 0.460036712522971 no 1524 0.415455102722659 1976 5392207 SGTC_2068 5226020 147 µM 0.213276965921598 0.460134198120934 no 1525 0.415555469384763 1891 1810509 SGTC_674 0498-0004 451 µM 0.211452516683135 0.460825307007218 no 1526 0.416267090320498 1880 4231473 SGTC_1215 3852-0577 11.2 µM 0.211374540452386 0.460854847376472 no 1527 0.416297510849383 2015 2884876 SGTC_2416 tofa 880 nM 0.210681631209386 0.461117357286548 no 1528 0.416567854532319 1782 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_1308 1187-1617 41.4 µM 0.21032744702226 0.461251547152583 no 1529 0.416706057372415 1907 2882570 SGTC_1921 5740136 50 µM 0.210258969343611 0.461277491820046 no 1530 0.416732778583774 2070 1774243 SGTC_1247 0448-0043 5.84 µM 0.210154382388296 0.461317117806338 no 1531 0.416773591021319 1907 3089013 YGL099W LSG1 SGTC_2761 levamisole 97.89 µM 0.210089696051087 0.461341626407919 no 1532 0.416798833691879 2040 26879 An alkaline phosphatase inhibitor. SGTC_1354 1498-1681 81 µM 0.209628044266274 0.461516543021732 no 1533 0.41697899488725 1935 5754243 SGTC_383 2324-0395 7.37 µM 0.208490095062833 0.461947735691559 no 1534 0.417423157857362 1984 3146421 SGTC_1596 piperlongumine 63 µM 0.207845283884139 0.462192087971964 no 1535 0.417674886598697 2059 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_965 1291-5240 308 µM 0.207252811420786 0.462416618990088 no 1536 0.417906212500323 2015 2834598 SGTC_2853 9015042 58.44 µM 0.206997094618739 0.462513532436947 no 1537 0.418006063760576 1926 6457456 SGTC_2137 5261020 140 µM 0.206943409609014 0.462533878662218 no 1538 0.418027027137056 1932 763655 SGTC_135 0933-0004 26.348 µM 0.206691545437657 0.462629334645344 no 1539 0.418125380296558 1877 21230617 YGL099W LSG1 SGTC_866 0495-0101 262 µM 0.206639437177492 0.462649083833548 no 1540 0.418145729253094 1847 635694 SGTC_3291 9121177 71.43 µM 0.2047922260265 0.463349241571285 no 1541 0.418867230512444 1909 17015612 SGTC_1303 1160-0052 261 µM 0.204576964457281 0.46343084067537 no 1542 0.418951327223852 2047 3562476 SGTC_2799 7812892 81.82 µM 0.202877787566969 0.464075000607198 no 1543 0.419615278096817 2031 20205235 SGTC_2388 9080168 200 µM 0.202448882277099 0.464237614054285 no 1544 0.419782908465799 1856 15943073 SGTC_2105 5350118 200 µM 0.200020446787985 0.465158433311585 no 1545 0.420732295010189 1914 2133313 SGTC_880 0833-0487 87.2 µM 0.199422577081591 0.465385163615027 no 1546 0.420966100600465 1900 76075 SGTC_804 1595-0054 20.9 µM 0.19935122010337 0.465412225094807 no 1547 0.420994007641972 1933 761523 Stimulates phospholipase C. SGTC_2752 diclazuril 33.15 µM 0.198963945145004 0.46555909835876 no 1548 0.421145474147809 2074 456389 An antifungal agent for coccidioides. YHR062C RPP1 SGTC_388 3',4'-dichloroisocoumarin 16.7 µM 0.198659275333933 0.465674647081784 no 1549 0.421264641286969 1979 1609 A potent and irreversible inhibitor of serine proteases. SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM 0.198628320008418 0.46568638732514 no 1550 0.421276749413487 1917 4330530 SGTC_1645 Cervolide 78 µM 0.198258320308083 0.465826717233618 no 1551 0.421421479969793 1945 23173 A fragrance. SGTC_1592 4',5'-dihydroxyflavone 8.85 µM 0.198116973971318 0.465880326828063 no 1552 0.421476772369522 1897 688669 SGTC_74 000s-0487 160.283 µM 0.197967695952769 0.465936945409296 no 1553 0.421535169195946 2099 677548 SGTC_3171 9103192 49.47 µM 0.19555914820364 0.466850560592798 no 1554 0.422477618909366 2093 13018434 SGTC_3181 9108277 49.47 µM 0.195487885090789 0.466877594944716 no 1555 0.422505510509863 1939 17097298 SGTC_2322 7413319 38.22 µM 0.194696606857773 0.467177784244456 no 1556 0.422815234208041 1962 1840400 SGTC_1635 st007035 42.4 µM 0.194156420310217 0.467382726965841 no 1557 0.42302670251933 2024 3716403 SGTC_2318 6029776 164 µM 0.194078018423647 0.467412472772942 no 1558 0.423057396565796 2002 818325 SGTC_499 genistein 192 µM 0.194031982305107 0.467429939038244 no 1559 0.42307541975232 2086 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger. SGTC_3085 9117376 49.47 µM 0.193943940793221 0.467463342472145 no 1560 0.42310988854074 1974 16480349 SGTC_578 3460-0051 92 µM 0.193640591656615 0.467578436556504 no 1561 0.42322865608226 2081 2876744 SGTC_1154 4088-0362 150 µM 0.193389404039466 0.467673742023831 no 1562 0.423327006577043 2033 6618304 SGTC_1826 st055655 41.6 µM 0.192851916456878 0.467877681484175 no 1563 0.423537471566427 1946 676168 SGTC_2362 9071156 126 µM 0.192705114575757 0.467933384139403 no 1564 0.423594958841382 2042 653133 SGTC_741 4582-0002 126 µM 0.192131285389085 0.468151124483837 no 1565 0.423819684607048 1929 2912688 SGTC_1391 3442-0225 151 µM 0.191523979886109 0.468381577843683 no 1566 0.42405754751624 1962 5227075 SGTC_691 1548-0686 185 µM 0.189645324489818 0.46909453529371 no 1567 0.424793533927394 1924 46495133 SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM 0.189293587075914 0.469228032173489 no 1568 0.424931360619068 2015 4620898 SGTC_130 0136-0219 337.655 µM 0.189196718438236 0.469264797880789 no 1569 0.424969319762651 2103 234244 SGTC_1479 0549-0158 134 µM 0.188628039477389 0.469480640652208 no 1570 0.425192177488862 1963 5440202 SGTC_2290 7904846 200 µM 0.188149862033447 0.469662140410134 no 1571 0.425379587379094 1928 2962154 SGTC_1315 1237-0019 3.69 µM 0.18769126888363 0.469836212564077 no 1572 0.425559337527465 2076 825140 SGTC_541 4513-1321 94 µM 0.187010707610958 0.470094549687235 no 1573 0.425826118797812 1908 747515 SGTC_815 1582-0027 36.9 µM 0.183810990772852 0.471309310621195 no 1574 0.427080866829883 2016 3128206 SGTC_3304 9125678 46.087 µM 0.183673983257038 0.471361331070563 no 1575 0.427134610000441 1955 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2 SGTC_2451 5856223 45.7 µM 0.183367337999046 0.47147776312495 no 1576 0.427254900917127 1942 2179896 SGTC_1129 3453-1384 223 µM 0.182771765678333 0.471703906657888 no 1577 0.427488551566615 1999 1084452 SGTC_2163 5671233 125 µM 0.182480073244414 0.471814667920977 no 1578 0.427602995528666 2066 701023 SGTC_961 1252-1571 372 µM 0.182042373369541 0.471980875122515 no 1579 0.42777473615301 2080 6813498 SGTC_194 1486-1323 56.904 µM 0.18154850769443 0.472168415947412 no 1580 0.427968531023947 1939 5178754 SGTC_1248 0469-0687 58.6 µM 0.18066304704963 0.472504676685305 no 1581 0.428316032807005 2015 4017482 SGTC_2051 5263410 176 µM 0.180306080223416 0.472640243239131 no 1582 0.428456141286555 2114 227584 SGTC_798 1287-0182 476 µM 0.180213356474267 0.472675457784398 no 1583 0.428492536574594 2101 1649755 SGTC_2136 5328288 199.296 µM 0.178737090608438 0.473236141342643 no 1584 0.429072072013865 1970 262395 SGTC_1716 st033144 30.6155 µM 0.177846853795109 0.473574277648796 no 1585 0.429421624921405 2101 674617 SGTC_3198 9112019 49.47 µM 0.176909174407217 0.473930454528541 no 1586 0.429789866077122 2012 45595555 SGTC_1412 3909-8563 178 µM 0.176337294291513 0.47414769305204 no 1587 0.430014482228535 2104 23767530 SGTC_1891 st059073 26.2 µM 0.175726308132363 0.474379795172877 no 1588 0.430254483005415 2131 688754 SGTC_1513 0337-0559 19 µM 0.174888060900789 0.474698243623743 no 1589 0.430583795857349 1930 775073 SGTC_610 4215-0184 155 µM 0.173704391426483 0.475147944778639 no 1590 0.431048893068148 2024 5605015 SGTC_91 0417-1751 58.384 µM 0.173661470757589 0.475164251849996 no 1591 0.431065759613394 2117 6795624 SGTC_2267 7931562 200 µM 0.173194914249201 0.47534151575165 no 1592 0.431249110537503 1851 934880 SGTC_3044 9093193 49.47 µM 0.171862580005914 0.47584775078066 no 1593 0.431772782814855 1941 25236277 SGTC_1889 st059080 5.18 µM 0.171850403459236 0.475852377574341 no 1594 0.431777569345406 2153 176925 Isolated from Daphnopsis sellowiana. SGTC_2505 galangin 7.89 µM 0.171819143268201 0.475864255706926 no 1595 0.431789857592788 1916 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_1548 st061468 90.8 µM 0.17100974188951 0.476171816507239 no 1596 0.432108052757656 2099 390799 SGTC_2434 5670830 169.91 µM 0.169527237293765 0.476735183463953 no 1597 0.432690975074067 1992 1549830 SGTC_1561 5-methoxyflavone 52.9 µM 0.167927885450182 0.477343005686244 no 1598 0.433320006109667 2123 94525 SGTC_1988 st071872 53.4 µM 0.167330687033965 0.47756998026206 no 1599 0.433554929879351 2137 16414116 SGTC_615 k087-0205 167 µM 0.166589520713659 0.477851682196379 no 1600 0.433846519866047 1988 9642773 SGTC_1182 1222-0449 220 µM 0.165368442665921 0.478315812685791 no 1601 0.434326995390008 2055 658318 SGTC_3158 9100007 49.47 µM 0.163507298111062 0.479023288147895 no 1602 0.435059513708891 1971 19297233 SGTC_547 1120-0019 610 nM 0.163491691468621 0.479029220971562 no 1603 0.435065657193122 1993 3676939 SGTC_1428 4049-0204 61.7 µM 0.162562348948724 0.479382516391961 no 1604 0.435431516881709 2109 X1428 SGTC_254 nsc-64875 3.808 µM 0.16160817706934 0.479745267701264 no 1605 0.43580720879798 2121 56993 SGTC_2653 dihydrofissinolide 100 µM 0.16127553205035 0.479871734637015 no 1606 0.435938196787829 2049 6857746 SGTC_753 1322-0200 289 µM 0.160442123066585 0.480188593825612 no 1607 0.436266404985492 2041 5403907 SGTC_1718 roemerine 11.9335 µM 0.160078810116551 0.480326728071905 no 1608 0.436409496492824 2125 235224 An aporphine alkaloid with mutagenic activity. SGTC_369 0957-0393 4.5 µM 0.159663872815608 0.480484493163696 no 1609 0.43657293052952 1962 6997992 SGTC_2528 xanthyletin 44.79 µM 0.159297978362931 0.480623614000804 no 1610 0.436717056727363 2011 65188 An natural product with antifungal activity of unknown mechanism. SGTC_757 1066-0008 322 µM 0.158610691751045 0.480884941325176 no 1611 0.436987802319606 2095 6842497 SGTC_2142 5622915 118.518 µM 0.157520223316783 0.481299587483056 no 1612 0.437417435473103 2005 5322196 SGTC_3340 9146634 11.102 µM 0.157188359066887 0.481425781541676 no 1613 0.437548201186581 2019 4907387 SGTC_58 0957-0393 9 µM 0.156738866283542 0.481596707764557 no 1614 0.437725327386014 2004 6997992 SGTC_2073 5212005 126 µM 0.155662282413075 0.482006108265754 no 1615 0.438149614479791 2181 691789 SGTC_552 k242-0005 476 µM 0.155416085212236 0.48209973417554 no 1616 0.438246652036847 2023 4088318 SGTC_3134 9127454 49.47 µM 0.154524937147304 0.482438635555796 no 1617 0.438597925176633 2168 24262820 SGTC_288 1315-0019 35.1 µM 0.154026323631108 0.482628262581121 no 1618 0.438794489996819 2052 6811474 SGTC_1905 st060207 84.5 µM 0.153485124714284 0.482834089648316 no 1619 0.439007860037459 1996 1948547 SGTC_1749 st037932 54.2 µM 0.152326269528642 0.483274837118575 no 1620 0.439464803296664 2030 594497 SGTC_1152 3909-8331 15.9 µM 0.152128186580968 0.48335017607959 no 1621 0.439542916630604 1991 16001939 SGTC_167 3672-0051 66.205 µM 0.152042273970635 0.483382852306999 no 1622 0.439576796707131 2081 3237971 SGTC_2537 larixol 68.93 µM 0.150064365673587 0.484135165551236 no 1623 0.440356916824497 2053 6708759 SGTC_247 mechlorethamine 29.705 µM 0.146504434431619 0.485489354393902 no 1624 0.441761594760317 2047 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links. SGTC_2565 isoliquiritigenin 100 µM 0.145296828677697 0.485948763366093 no 1625 0.442238259252518 1866 638278 Binds to benzodiazepine receptor 65X better than valium. SGTC_2245 6637752 200 µM 0.144944749537531 0.486082708230433 no 1626 0.442377247227765 2143 681890 SGTC_1217 1183-1422 255 µM 0.144257488555489 0.486344174066985 no 1627 0.442648573163291 2113 2849664 SGTC_2275 7947463 200 µM 0.14417010239784 0.486377420222572 no 1628 0.442683074551042 2159 1225414 SGTC_590 k048-0076 22.4 µM 0.143826125330645 0.486508287577226 no 1629 0.442818886163588 2159 6832814 SGTC_1628 st004252 77.7 µM 0.143606607814144 0.486591804593252 no 1630 0.44290556123357 2123 692968 SGTC_904 1141-0088 396 µM 0.143461414058586 0.486647044923876 no 1631 0.442962891549375 1968 1378119 SGTC_2381 9035592 200 µM 0.143187337294019 0.486751320705548 no 1632 0.443071115073399 1974 4749657 SGTC_1067 clotrimazole 1.36 µM 0.142914933178997 0.486854961005264 no 1633 0.443178682333882 2032 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_2610 ononetin 44.17 µM 0.142888881613363 0.486864872767319 no 1634 0.443188969826585 2033 259632 SGTC_2377 9073351 62.6 µM 0.141536416991149 0.487379451980463 no 1635 0.44372309649968 1961 7337946 YHR072W ERG7 SGTC_2834 9001755 58.44 µM 0.140420084790974 0.487804204536164 no 1636 0.444164044850975 2010 2989575 SGTC_1153 4055-0057 267 µM 0.140268982301955 0.487861698503392 no 1637 0.444223735269489 2002 882706 SGTC_2464 5717415 7.67 µM 0.13789473439203 0.488765123861565 no 1638 0.445161805999802 2004 5285744 SGTC_990 3985-0011 41.3 µM 0.137787753519925 0.488805832558137 no 1639 0.445204081655931 2090 5399565 YGL099W LSG1 SGTC_3206 9114350 49.47 µM 0.136776494314951 0.489190645781021 no 1640 0.445603731912124 2181 17087243 SGTC_2774 tamoxifen 10.92 µM 0.135878813082232 0.48953224775958 no 1641 0.44595854241415 2140 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  SGTC_1237 0330-0133 46.1 µM 0.135154002340468 0.489808071531573 no 1642 0.446245057064905 2073 X1237 YHR072W ERG7 SGTC_2988 9073640 71.4286 µM 0.134750360854544 0.489961677774413 no 1643 0.446404627031387 2117 9102229 SGTC_2046 4110841 106 µM 0.134189710460118 0.490175036407556 no 1644 0.446626281093365 2200 44119630 YMR134W ERG29 SGTC_2419 paclitaxel 166.5 µM 0.131815174414052 0.491078709776178 no 1645 0.447565241919405 2019 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_2298 7976326 193.81 µM 0.130555997611698 0.491557931543782 no 1646 0.448063276756133 2122 2235818 SGTC_1374 2889-5571 141 µM 0.13032237207035 0.491646846903555 no 1647 0.448155690328692 2058 2853281 SGTC_2436 5633522 8.09 µM 0.130301796784071 0.491654677655418 no 1648 0.448163829281364 2190 5724242 SGTC_2649 anisomycin 9.56 µM 0.129699488986883 0.491883911499568 no 1649 0.448402093441335 2097 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_1803 st050068 52.4 µM 0.129474948412645 0.491969370653183 no 1650 0.448490923177755 2181 3984059 YIL048W | YNL267W NEO1 | PIK1 SGTC_3093 9117344 49.47 µM 0.129346787467483 0.492018148309945 no 1651 0.448541625653359 2104 24824913 SGTC_1607 st000305 50.6 µM 0.129290804997692 0.492039455101171 no 1652 0.448563773458335 2167 5457690 SGTC_1401 3807-4679 7.6 µM 0.128154140232866 0.492472071761279 no 1653 0.449013495759976 2150 3291456 SGTC_2291 7917025 104.35 µM 0.128129938977963 0.492481282900632 no 1654 0.449023071719706 2072 2964612 SGTC_2978 9011784 42.97 µM 0.127482574551603 0.492727675064951 no 1655 0.449279232071221 2193 2994934 SGTC_561 1550-0330 72.9 µM 0.127069396990332 0.492884935260786 no 1656 0.449442736373321 2053 6812934 SGTC_2343 7990716 14.84 µM 0.126731868586373 0.493013403327355 no 1657 0.449576310855803 2125 6456862 SGTC_2981 9013952 38.96 µM 0.12621500839921 0.493210128997401 no 1658 0.449780865694094 1940 2996344 SGTC_558 k064-0027 21.3 µM 0.122077538345512 0.494784975100184 no 1659 0.45141880530769 2133 5088526 SGTC_1737 st035557 69.7 µM 0.121199037720666 0.495119370269673 no 1660 0.451766693143681 2209 5716916 SGTC_707 0865-0008 204 µM 0.120428338131019 0.495412734554765 no 1661 0.452071922087091 2115 723043 SGTC_3223 9129970 49.47 µM 0.120222705322081 0.495491008438605 no 1662 0.452153365987676 2147 17248386 SGTC_1187 1391-0724 117 µM 0.119653316744213 0.495707746419247 no 1663 0.452378891210358 2088 6997986 SGTC_1594 piperine 70.1 µM 0.118169881307614 0.496272422476991 no 1664 0.452966526976129 2099 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_2334 9017922 200 µM 0.117820403560895 0.496405453808287 no 1665 0.453104981222902 2164 3163164 SGTC_2960 9079389 5.97 µM 0.117556421771104 0.496505940726711 no 1666 0.453209567913793 2196 16457355 SGTC_789 1309-1135 70.6 µM 0.114453917985155 0.497686950139196 no 1667 0.454438987196228 2211 3092424 SGTC_1987 st072290 61.9 µM 0.113485182254075 0.498055716944517 no 1668 0.454822955017527 2088 54697379 SGTC_2488 5268135 45.7 µM 0.113105525518223 0.498200240629297 no 1669 0.454973447188095 2149 1270356 YLR208W SEC13 SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM 0.1130857317324 0.498207775523623 no 1670 0.454981293426221 2131 2724278 An inhibitor of dopamine biosynthesis. SGTC_2338 7999974 200 µM 0.112470114381513 0.498442122695841 no 1671 0.455225332318733 2203 315925 SGTC_230 MPP+ 141.667 µM 0.112363352923658 0.498482763656954 no 1672 0.455267655700137 2073 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death. SGTC_1838 st055369 84.5 µM 0.110908368008272 0.499036635206003 no 1673 0.455844504916638 2213 676036 SGTC_1467 k284-1082 293 µM 0.110559527686517 0.499169429152784 no 1674 0.455982821445338 2233 3334705 SGTC_1236 0330-0013 258 µM 0.110143933495587 0.499327634586355 no 1675 0.456147613101983 2104 4617066 SGTC_783 0848-0141 92.7 µM 0.109136533916115 0.499711124665674 no 1676 0.456547099033942 2219 6755076 YHR007C | YLR033W ERG11 | RSC58 SGTC_3329 9141233 27.5565 µM 0.108952234014997 0.49978128274868 no 1677 0.456620188222371 2187 4909101 YNL103W MET4 SGTC_336 4111-0029 111 µM 0.108484466568239 0.499959349431487 no 1678 0.456805700836739 2108 3131175 SGTC_1549 4'-methoxyflavonol 74.6 µM 0.108270894762294 0.499959349431487 no 1679 0.456890404742021 2209 97141 SGTC_683 panaxydol 45 µM 0.108057949970111 0.499878286983692 no 1680 0.456974861919818 2183 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis. SGTC_3052 9092717 49.47 µM 0.107748405664353 0.499760451666998 no 1681 0.457097635414312 2120 25237534 SGTC_92 0063-0024 660.874 µM 0.107549736968888 0.499684823768169 no 1682 0.457176434854633 2237 3594437 SGTC_2110 5483698 200 µM 0.107514575295085 0.499671438653398 no 1683 0.457190381465936 2106 2848765 YHR062C RPP1 SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM 0.106411915287286 0.499251685557434 no 1684 0.457627769861488 2114 689007 SGTC_2240 6690706 185.951 µM 0.106270064339493 0.499197686755836 no 1685 0.457684041131649 2069 805876 SGTC_1323 1348-1351 11.2 µM 0.105566103499504 0.498929708228162 no 1686 0.457963309958697 2085 6989654 SGTC_3155 9099265 49.47 µM 0.102509776863954 0.497766255911095 no 1687 0.459176026458282 2157 25236499 SGTC_272 doxorubicin 8.13 µM 0.102451879626123 0.497744216313043 no 1688 0.459199003142776 2221 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_318 1488-0629 67.2 µM 0.101638084539729 0.497434431713609 no 1689 0.459521974437355 2110 3662576 SGTC_3016 9080866 49.47 µM 0.101486135269753 0.497376589869136 no 1690 0.459582281592133 2208 17066299 SGTC_1106 tegaserod maleate 11.7 µM 0.101012063701441 0.497196127539627 no 1691 0.459770441855754 2127 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation. SGTC_3179 9107801 49.47 µM 0.100572754811258 0.497028898647274 no 1692 0.459944812764844 2194 4818259 SGTC_2330 7979373 200 µM 0.0993353184408032 0.496557854597631 no 1693 0.460436018510634 2103 1863007 SGTC_400 oxethazaine 37.5 µM 0.0990280530057949 0.496440891277755 no 1694 0.460557998247866 2123 4621 A local anesthetic. SGTC_2520 obtusaquinone 4.71 µM 0.0975523892713937 0.495879171196913 no 1695 0.461143865979484 2216 5967872 SGTC_70 0141-0289 43.283 µM 0.09680374992534 0.495594200280024 no 1696 0.461441122956943 2120 352408 SGTC_1442 4112-3290 3 µM 0.0960998590418464 0.495326264994104 no 1697 0.461720631629281 2239 704353 SGTC_1363 1636-0063 10.4 µM 0.0956473900382079 0.495154034274167 no 1698 0.461900312950286 2188 6072185 SGTC_1562 morin hydrate 59.1 µM 0.0953847858311884 0.495054075327223 no 1699 0.462004600061979 2150 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase. SGTC_2420 aureobasidin a 50 nM 0.0952117479819816 0.494988209525164 no 1700 0.462073319420148 2217 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1 SGTC_1472 k841-0093 193 µM 0.0950554910343167 0.494928731388286 no 1701 0.462135375470569 2217 X1472 SGTC_1512 0259-0544 12.2 µM 0.0937896612482673 0.494446906221387 no 1702 0.462638122305264 2133 18476 SGTC_605 1315-0399 119 µM 0.0930080652005008 0.494149403676987 no 1703 0.462948576947783 2186 24020461 SGTC_2945 9067681 61.76 µM 0.0925906927633241 0.493990538584315 no 1704 0.463114369041374 2240 16456930 SGTC_2092 5303694 80.6725 µM 0.0921654310496683 0.493828671565032 no 1705 0.463283301567651 2141 1963699 SGTC_2192 5915882 198.485 µM 0.0915823417283251 0.493606732409253 no 1706 0.463514940870266 2228 2876149 SGTC_1381 2324-0066 62.1 µM 0.0906633705914109 0.493256951830511 no 1707 0.463880038376856 2164 10885928 SGTC_519 k048-0011 62.8 µM 0.0906563280061489 0.493254271287707 no 1708 0.463882836439291 2138 6836379 SGTC_2266 7929956 200 µM 0.0903641313805377 0.493143055926862 no 1709 0.463998929528616 2260 2967153 SGTC_3113 9123498 49.47 µM 0.0892068892734294 0.492702593810129 no 1710 0.464458745180329 2267 8897275 SGTC_34 0469-0683 81.75 µM 0.088341554985224 0.492373241571713 no 1711 0.464802605971009 2183 3690923 SGTC_1720 st037298 9.481 µM 0.0880896700968754 0.492277373401287 no 1712 0.464902703265501 2171 597396 SGTC_768 0384-0033 77.3 µM 0.087698027598616 0.492128313938694 no 1713 0.465058343666654 2068 3965305 YMR134W ERG29 SGTC_2895 9054447 58.44 µM 0.0874341634252837 0.492027887631988 no 1714 0.465163207431408 2175 2697450 SGTC_1819 st053448 58.6 µM 0.0871556735159175 0.491921895340422 no 1715 0.465273886317299 2169 2857616 SGTC_431 k089-0097 107 µM 0.0864726610256426 0.491661945590702 no 1716 0.465545343995129 2260 5499420 SGTC_2921 7974240 10.71 µM 0.0862000265545503 0.49155818381131 no 1717 0.465653704800101 2202 2979074 YDR527W RBA50 SGTC_1000 4048-0884 8.67 µM 0.0858110596294604 0.491410148128071 no 1718 0.465808307298796 2179 13040088 SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM 0.0852530770401617 0.491197789382582 no 1719 0.466030097378251 2196 5393153 SGTC_2408 sulbentine 18.36 µM 0.0834941198075013 0.490528376591236 no 1720 0.466729326391042 2125 67686 An antifungal agent of unknown mechanism. YDL205C HEM3 SGTC_662 k832-1615 104 µM 0.0830547290574262 0.490361160136188 no 1721 0.466904011198961 2190 5878478 SGTC_3034 9090421 49.47 µM 0.0828091205272681 0.49026769102188 no 1722 0.467001658453324 2254 17173761 SGTC_708 3448-5400 146 µM 0.0811093440140249 0.489620836699502 no 1723 0.467677497362728 2267 3462195 SGTC_1265 0819-1001 68.8 µM 0.0798779403717515 0.489152239831325 no 1724 0.468167167395181 2273 3106768 SGTC_2204 7233102 200 µM 0.0795040710921928 0.489009970996635 no 1725 0.468315846801028 2216 2172480 SGTC_901 1112-0062 60.1 µM 0.0788840285032528 0.488774028688303 no 1726 0.468562433529102 2268 1908457 SGTC_1728 st035614 33.7865 µM 0.0784665835573981 0.488615182252625 no 1727 0.468728455349363 2133 15945546 SGTC_1852 st056254 31.4 µM 0.0779697406216181 0.488426125595496 no 1728 0.46892606159014 2185 442583 SGTC_1226 3909-7979 35.4 µM 0.0777773857757989 0.488352932206374 no 1729 0.469002567740995 2259 6615510 SGTC_432 NS 1619 61.3 µM 0.0769557789714269 0.488040305139373 no 1730 0.469329361931279 2137 4552 A K+/calcium channel activator. SGTC_195 4234-0266 16.654 µM 0.0768810637108286 0.488011875828008 no 1731 0.469359080962067 2147 2303354 SGTC_1399 3562-5772 25 µM 0.0761824355996856 0.487746049352334 no 1732 0.469636978218178 2258 23847490 SGTC_99 0109-0120 622.8 µM 0.0737503370526536 0.486820684374208 no 1733 0.470604522318339 2261 759414 SGTC_340 k038-0059 454 µM 0.0736548062052667 0.486784338208285 no 1734 0.470642530241282 2274 23733424 SGTC_35 0133-0054 64.071 µM 0.0735789082480113 0.48675546175268 no 1735 0.470672727209105 2213 99677 SGTC_950 1165-0508 94.1 µM 0.0735012761648599 0.486725925596095 no 1736 0.470703614295434 2198 6148369 SGTC_1032 k061-1018 98.7 µM 0.0733319402237121 0.486661499742237 no 1737 0.470770987745589 2283 4005393 SGTC_503 tyrphostin 8 294 µM 0.0725922053684869 0.486380063005441 no 1738 0.471065314785669 2279 92970 A tyrosine kinase inhibitor. YOR207C RET1 SGTC_1204 4049-0315 18.3 µM 0.0724770046859212 0.48633623479456 no 1739 0.471111152467721 2232 588402 SGTC_3301 9125354 19.7965 µM 0.0721828080330212 0.486224308144156 no 1740 0.471228213341321 2252 41905162 SGTC_2237 6667747 47.222 µM 0.0704946296922685 0.485582064618288 no 1741 0.47189998740144 2124 729940 YDL015C TSC13 SGTC_2328 6201408 200 µM 0.0704635180708423 0.485570228988648 no 1742 0.471912368354468 2205 2890418 SGTC_1175 0741-0056 27.6 µM 0.0704485509669076 0.485564535136963 no 1743 0.471918324563213 2266 765927 SGTC_1131 3454-3128 32.3 µM 0.0695016431701988 0.485204314328982 no 1744 0.472295162378761 2195 710982 SGTC_2151 5563267 85.4165 µM 0.0678543659340136 0.484577689295415 no 1745 0.472950782845099 2176 5310824 SGTC_93 0109-0045 59.227 µM 0.0671250375859687 0.484300264521672 no 1746 0.473241080866196 2288 88733 SGTC_344 k064-0035 6.43 µM 0.0668857744181573 0.484209254309722 no 1747 0.473336319023061 2188 5088750 SGTC_392 N-ethylmaleimide 8.33 µM 0.0656781706160812 0.483749922219745 no 1748 0.473817026102739 2239 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides. SGTC_2481 5478948 45.16 µM 0.0654408132500909 0.483659641934424 no 1749 0.473911514714784 2201 77792 SGTC_2925 9010536 32.5 µM 0.064632590295058 0.483352235839058 no 1750 0.474233267823494 2216 2994177 SGTC_3282 9108498 15.4605 µM 0.0636733016412021 0.482987385044429 no 1751 0.474615181899965 2218 16459645 SGTC_1062 mesoridazine 14.2 µM 0.0631777081391834 0.482798899183648 no 1752 0.474812497819672 2295 4078 A neuroleptic. SGTC_1275 0867-0008 21.1 µM 0.0630078455996284 0.482734297348699 no 1753 0.474880128425902 2236 3422836 SGTC_2972 9093619 59.92 µM 0.0609951420749936 0.481968864308106 no 1754 0.475681538958182 2252 25236256 SGTC_3154 9100113 49.47 µM 0.0607559323857845 0.481877897002516 no 1755 0.475776793155264 2234 25237525 SGTC_1672 st016598 6.51 µM 0.0602414261174186 0.481682242374826 no 1756 0.475981676168545 2164 4665860 YNL267W PIK1 SGTC_1912 st060209 90.8 µM 0.0586409901691717 0.481073662660246 no 1757 0.476619030703545 2233 688787 SGTC_1227 3909-8010 46.6 µM 0.0584326416047374 0.480994439517676 no 1758 0.476702007470572 2237 15982272 SGTC_2546 rhodinyl acetate 100 µM 0.0583104605659741 0.480947981347087 no 1759 0.476750667683651 2306 6708682 SGTC_1760 st045453 10.4495 µM 0.0577514669497175 0.480735432684365 no 1760 0.476973298687703 2300 3323419 YIL048W NEO1 SGTC_2252 omeprazole 400 µM 0.0567155186423972 0.480341543914355 no 1761 0.477385905912559 2252 4594 A proton pump inhibitor. SGTC_1353 1498-1206 8.11 µM 0.0544095899026554 0.479464852040069 no 1762 0.478304419268377 2290 6756808 SGTC_1817 st052116 64.4 µM 0.0537425003201971 0.479211249350205 no 1763 0.47857016067554 2290 4361398 SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM 0.0533147640483559 0.479048644323312 no 1764 0.478740558461367 2320 16725076 SGTC_1919 st067113 52.3 µM 0.052191343231375 0.478621589730683 no 1765 0.479188115317423 2260 1268243 SGTC_690 glyoxal 20.3 µM 0.0519853009376323 0.478543267938409 no 1766 0.479270202864543 2275 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins. SGTC_2926 9010726 65.15 µM 0.0518246683578443 0.478482208080661 no 1767 0.479334199726221 2250 2994293 SGTC_1867 st057372 64 µM 0.0517473682966884 0.478452824864348 no 1768 0.479364996665699 2308 688837 SGTC_2521 angolensin 13.4 µM 0.0516947254930283 0.478432814405328 no 1769 0.479385970034487 2255 821428 A flavenoid. SGTC_1267 0828-0272 9.49 µM 0.0504720271587911 0.477968060583809 no 1770 0.479873120039315 2295 745334 SGTC_1550 gossypolone 36.6 µM 0.0495974985263758 0.477635666167804 no 1771 0.48022157003366 2310 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_221 trifluoperazine 10.304 µM 0.049407324828034 0.477563386222876 no 1772 0.480297345462115 2298 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1 SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM 0.049232357100916 0.477496886313429 no 1773 0.480367062642832 2307 803109 SGTC_285 1486-1325 46 µM 0.0491353983502272 0.477460035512096 no 1774 0.480405696830561 2309 22310230 SGTC_2760 etidronate 98.04 µM 0.0474747409503599 0.476828904963058 no 1775 0.481067430715915 2306 3305 A chelator and antioxidant. SGTC_1456 k015-0012 13 µM 0.0472722526917945 0.476751953523905 no 1776 0.481148121247793 2337 2989616 SGTC_1311 1190-0148 100 µM 0.0438291116243442 0.475443594617895 no 1777 0.482520310827374 2311 1961333 SGTC_3022 9087993 49.47 µM 0.0435161152499907 0.475324672065157 no 1778 0.482645059291268 2330 17173644 SGTC_2406 ethylparaben 405.7 µM 0.0434247219490461 0.475289947717189 no 1779 0.482681485509984 2218 8434 A possible steroid mimic. SGTC_1775 st081588 35.1725 µM 0.0433857808227832 0.475275152321961 no 1780 0.482697006144247 2320 1426443 YGL099W LSG1 SGTC_653 0203-0016 55.2 µM 0.0428250161814503 0.475062097701195 no 1781 0.482920511125067 2293 295302 SGTC_566 0958-0068 16.5 µM 0.0403170732298461 0.474109328251314 no 1782 0.483920171188096 2318 6815365 SGTC_1341 1486-1360 280 µM 0.0402114195789677 0.474069193560476 no 1783 0.483962286743581 2337 3976547 SGTC_338 4055-0136 114 µM 0.0399605217961045 0.473973885983644 no 1784 0.484062300089697 2329 2900563 SGTC_1500 4488-1866 171 µM 0.0382099329117417 0.473308938267167 no 1785 0.484760150681132 2331 2900003 SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM 0.0376875717064223 0.473110537705001 no 1786 0.484968392649771 2301 688761 SGTC_1717 st033143 58.0435 µM 0.0372210328209132 0.472933344928666 no 1787 0.485154384232405 2346 674616 SGTC_869 0564-0080 44.1 µM 0.0368235112448525 0.472782369344519 no 1788 0.485312863748334 2204 6843321 SGTC_1282 0886-0010 32.4 µM 0.0362756015192972 0.472574283931082 no 1789 0.485531302149572 2338 2836211 YNL267W PIK1 SGTC_106 0092-0003 11.579 µM 0.0362519659822299 0.472565307783686 no 1790 0.485540725166664 2342 1072148 SGTC_2930 9013230 14.89 µM 0.0357911005354726 0.472390286153157 no 1791 0.485724464632998 2328 2995857 SGTC_3151 9099821 49.47 µM 0.0351939552075403 0.472163517812351 no 1792 0.485962541146267 2308 17174189 SGTC_1469 k284-2957 126 µM 0.0330463871803861 0.471348045315086 no 1793 0.486818798101581 2306 23884841 SGTC_818 4072-2707 53.5 µM 0.0328857890026483 0.471287067911826 no 1794 0.486882832700096 2343 882871 SGTC_2442 5158906 48.48 µM 0.0322120583750525 0.47103126698002 no 1795 0.487151469988743 2329 1893835 SGTC_1417 3966-0327 90.4 µM 0.0315577276258803 0.47078284320129 no 1796 0.487412377526234 2330 651118 SGTC_725 1497-0963 19 µM 0.0298751855104291 0.470144100242187 no 1797 0.488083298053879 2345 3549977 SGTC_2231 micatex 6.853 µM 0.0295161417990359 0.470007806474657 no 1798 0.488226472628186 2301 20737 An antifungal of unknown mechanism. SGTC_751 0833-0568 350 µM 0.028634793071339 0.469673259527472 no 1799 0.488577931298112 2331 6954252 SGTC_2296 7971656 126.45 µM 0.0283197959316217 0.469553696450779 no 1800 0.488703546030474 2322 666570 SGTC_1134 3477-0009 42.5 µM 0.024792408022936 0.468215000154752 no 1801 0.490110273359389 2361 3973534 SGTC_1022 4477-0945 21.3 µM 0.0247266967314271 0.468190065102559 no 1802 0.490136480337733 2359 4648966 SGTC_873 0591-4978 488 µM 0.0241879621733426 0.467985639588821 no 1803 0.490351340058309 2353 3305145 SGTC_3055 9094636 49.47 µM 0.0235135193316145 0.467729730796354 no 1804 0.49062032729986 2338 25236176 SGTC_511 blebbistatin 171 µM 0.0234364068532925 0.467700472290894 no 1805 0.490651082252509 2365 3476986 A myosin inhibitor. SGTC_2973 9094665 17.96 µM 0.0231901311225059 0.467607029960912 no 1806 0.490749305357734 2356 25237061 YIL048W NEO1 SGTC_1742 st038235 28.8875 µM 0.0227025273530796 0.467422027832641 no 1807 0.490943779910041 2318 564103 YBR002C RER2 SGTC_315 k915-0449 187 µM 0.0214206106049245 0.466935688465797 no 1808 0.49145506622589 2330 20970215 YNL149C PGA2 SGTC_2339 9000433 200 µM 0.0206895348878542 0.466658351712871 no 1809 0.491746658592154 2350 2988954 SGTC_2457 5731572 11.68 µM 0.0199962173312141 0.46639535363534 no 1810 0.492023195047883 2376 2865357 SGTC_2820 7989630 71.43 µM 0.0191907351135564 0.466089826258361 no 1811 0.492344474275775 2378 2984098 SGTC_1431 4049-0260 9.09 µM 0.0189513189128237 0.46599901716853 no 1812 0.492439970152934 2367 3854841 SGTC_2071 5230951 39.92 µM 0.0185885299635919 0.465861416930445 no 1813 0.492584676509853 2366 1799272 SGTC_955 1216-0110 33 µM 0.0178703051241066 0.465589017408912 no 1814 0.492871159154285 2367 3619719 SGTC_1820 st053765 18.6 µM 0.0170714847804127 0.465286069554498 no 1815 0.493189793722887 2349 3690829 SGTC_746 1095-0025 46.6 µM 0.017023366134301 0.465267821485427 no 1816 0.493208987496096 2374 6749286 SGTC_976 1348-1067 47.6 µM 0.0166900851371529 0.465141433098013 no 1817 0.493341928487618 2386 5310671 YGL099W LSG1 SGTC_930 2810-3379 265 µM 0.0156188847267602 0.464735231317696 no 1818 0.493769219843489 2377 1015764 SGTC_3257 9139206 32.98 µM 0.0155536900438854 0.464710510518711 no 1819 0.493795225599929 2375 4910041 SGTC_2549 cedrol 20.94 µM 0.0152753876136288 0.464604984144619 no 1820 0.493906239016117 2374 6708665 A sedative which affects the nervous system. SGTC_1698 5-fluorocytosine 1.055 µM 0.0148935252951345 0.46446019411212 no 1821 0.494058562708415 2378 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_2254 7938975 95.19 µM 0.0144182622410774 0.464279996070287 no 1822 0.494248144871443 2382 2969277 SGTC_104 0074-0074 590.992 µM 0.0140816658056388 0.464152378506224 no 1823 0.494382413787224 2386 3943124 SGTC_1627 st003713 25.6 µM 0.0140241023997838 0.464130554218494 no 1824 0.494405375996179 2362 16195070 YER133W GLC7 SGTC_2316 5844804 197.44 µM 0.0139444183266879 0.464100343395148 no 1825 0.4944371622338 2369 776813 SGTC_149 3970-0822 46.1 µM 0.0134628244983273 0.463917759925974 no 1826 0.494629272333105 2378 3114250 YBL034C STU1 SGTC_3344 9148862 3.898 µM 0.0121673822184304 0.463426665317853 no 1827 0.495146036559216 2366 4905352 SGTC_2368 9071271 200 µM 0.0116543351295511 0.46323218752457 no 1828 0.495350698214521 2370 27209959 SGTC_670 4204-0025 119 µM 0.0112842397760019 0.463091903071808 no 1829 0.49549833518725 2372 719039 SGTC_1228 0124-0032 52.5 µM 0.00956227722646525 0.462439254691289 no 1830 0.496185261452333 2377 X1228 SGTC_3185 9108267 49.47 µM 0.00940919837194237 0.462381240488751 no 1831 0.496246328332141 2376 4910486 SGTC_2038 4100038 30.985 µM 0.0092694532017171 0.462328280217538 no 1832 0.496302076157681 2381 3596803 SGTC_2189 6047310 154.431 µM 0.009054412236223 0.462246785841133 no 1833 0.49638786149014 2374 711535 SGTC_513 4245-1575 41.7 µM 0.00890343847418947 0.462189572049421 no 1834 0.496448088879141 2378 719745 SGTC_2938 9059746 27.26 µM 0.00838531563253856 0.461993227514953 no 1835 0.496654782262053 2384 6471769 SGTC_2817 7995342 71.43 µM 0.00827849555485198 0.461952748808179 no 1836 0.496697395828262 2388 18879975 SGTC_1026 k007-1105 30.6 µM 0.00822379898521755 0.461932022085654 no 1837 0.496719215859697 2393 7066794 SGTC_2232 chlorophetanol 41.5365 µM 0.00741639040604248 0.461626074669843 no 1838 0.49704131542177 2392 15907 An antifungal of unknown mechanism. YFR051C RET2 SGTC_2801 7907800 81.82 µM 0.00728776410831173 0.46157733702307 no 1839 0.497092628503438 2387 6620925 SGTC_3142 9086498 49.47 µM 0.00723614007519066 0.461557776380578 no 1840 0.497113222969891 2392 25236367 SGTC_2456 5770359 74.46 µM 0.00625190894381539 0.461184863396522 no 1841 0.497505865436879 2397 3118787 SGTC_2592 piperlongumine 83.33 µM 0.00507834416103237 0.460740258871058 no 1842 0.497974042507837 2387 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_1941 st076221 61.8 µM 0.00420968632432177 0.460411199787758 no 1843 0.498320583098288 2400 2828568 SGTC_887 0885-0007 9.62 µM 0.00382011836301044 0.46026363508077 no 1844 0.498475996975565 2392 5719458 SGTC_2242 6630449 61.2675 µM 0.00300247119831207 0.459953935789093 no 1845 0.498802189092984 2379 691249 YDR170C SEC7 SGTC_831 k061-1017 217 µM 0.00200793382950901 0.459577268760259 no 1846 0.499198950837439 2400 1240153 SGTC_2018 5133068 143 µM 0.000124928087173188 0.458864206486889 no 1847 0.499950160904147 2404 785362 SGTC_3272 9137413 49.47 µM 0 0.458816902999336 no 1848 0.5 2405 17614870 SGTC_1706 st031321 9.9705 µM -0.000185942335395592 0.458746497806939 no 1849 0.499925819741122 2407 6103185 SGTC_3333 9141820 12.094 µM -0.00044102042549363 0.458649917163037 no 1850 0.499824058311453 2407 1939433 SGTC_1665 st014639 11.4 µM -0.000657405995113344 0.458567988646237 no 1851 0.499737732972051 2408 981133 YIL048W NEO1 SGTC_1757 st041620 31.8375 µM -0.000665063366908489 0.458565089422679 no 1852 0.499734678123353 2407 5289815 SGTC_1863 st057641 20.1 µM -0.00224153408078083 0.457968255414251 no 1853 0.499105758031065 2409 3921635 SGTC_1045 1348-1485 165 µM -0.00367721418114163 0.457424805550413 no 1854 0.498533007095141 2410 6810614 SGTC_1240 0356-0016 42.1 µM -0.00412502856385609 0.457255310025977 no 1855 0.498354356365023 2413 4305613 SGTC_261 5-fluorouridine 15.376 µM -0.00434218367927027 0.45717312068839 no 1856 0.498267724784619 2412 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_1113 artemisinin 1.17947 µM -0.00659938486933703 0.456318919423247 no 1857 0.497367245461229 2420 2240 An anti-malaria and mitochondrial poison. SGTC_1127 asiatic acid 681.4 nM -0.0071281914308463 0.456118830172477 no 1858 0.497156287137497 2428 470603 A kinase inhibitor which arrests cells at G2/M. SGTC_749 1000-0129 128 µM -0.00737082947998122 0.456027024772928 no 1859 0.497059491104711 2419 708470 SGTC_1745 st081495 74 µM -0.00844199903531947 0.455621761355842 no 1860 0.496632169656473 2424 13842402 YBL026W LSM2 SGTC_2791 5663188 71.43 µM -0.0107385180461088 0.454753058655391 no 1861 0.495716033457528 2431 54690634 SGTC_941 3237-0776 460 µM -0.0113885466478359 0.454507211879376 no 1862 0.495456725439757 2431 760008 SGTC_3063 1327-0034 4 µM -0.0134855744461311 0.45371421600408 no 1863 0.494620197240897 2414 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_2773 thioridazine 9.09 µM -0.0140426812230945 0.453503575686157 no 1864 0.494397964847837 2428 5452 An antipsychotic. SGTC_826 1683-5028 118 µM -0.0167632745005294 0.452475116929201 no 1865 0.493312734240393 2453 722377 SGTC_3027 9089541 49.47 µM -0.0168141154019231 0.452455900689116 no 1866 0.493292454513482 2458 9943819 SGTC_65 0798-0905 34.986 µM -0.0188937166851973 0.451669973644019 no 1867 0.492462946003222 2455 3602145 SGTC_2957 9076800 11.52 µM -0.0190333098151496 0.451617225079877 no 1868 0.492407266414179 2460 16459615 SGTC_3219 9131112 49.47 µM -0.0200721722794335 0.451224693234625 no 1869 0.491992899488099 2448 17612988 YMR079W SEC14 SGTC_3190 9110366 49.47 µM -0.0202971112246564 0.451139706828009 no 1870 0.491903180111115 2438 17123768 SGTC_934 2950-0684 338 µM -0.0210329485429488 0.450861708523807 no 1871 0.491609686173995 2438 1121253 SGTC_2341 7987486 176.74 µM -0.0231006680780387 0.450080656449807 no 1872 0.490784986390079 2457 1258686 SGTC_1167 k781-0610 148 µM -0.0246689572415966 0.449488385950691 no 1873 0.490159508037152 2466 4525169 SGTC_1379 2144-0755 36.5 µM -0.0253958716512988 0.449213901979649 no 1874 0.489869601996219 2450 5392327 SGTC_1014 4130-3005 69.3 µM -0.0254984495483773 0.44917517036553 no 1875 0.48982869258381 2465 743608 SGTC_206 4546-0025 72.014 µM -0.0256681113680932 0.449111110102371 no 1876 0.489761029457162 2461 6620745 YIL048W NEO1 SGTC_2152 5568786 200 µM -0.0260766222174817 0.448956871578368 no 1877 0.489598111744474 2448 5399883 SGTC_528 3492-0019 172 µM -0.0262746320448906 0.448882113196002 no 1878 0.489519144309949 2450 2869262 SGTC_1347 1493-0251 600 nM -0.0268593551925595 0.448661362247335 no 1879 0.489285955834671 2460 3986378 SGTC_3172 9105863 49.47 µM -0.0277630124118255 0.448320235175558 no 1880 0.488925583201349 2446 2348785 SGTC_341 1486-1430 230 µM -0.027802213083895 0.44830543793783 no 1881 0.488909950430267 2465 2054753 YPL210C SRP72 SGTC_2148 5546263 113.568 µM -0.0280205296639864 0.448223030403274 no 1882 0.488822888635248 2465 792097 SGTC_1759 st043059 70 µM -0.0283564619301079 0.448096231069974 no 1883 0.488688924285597 2473 669426 SGTC_2540 epiandrosterone 100 µM -0.0283758114566063 0.448088927654709 no 1884 0.488681208046385 2463 441302 A steroid. SGTC_1349 flufenamic acid 69 µM -0.0298026108878957 0.447550435543046 no 1885 0.488112238252822 2460 3371 A non-steroidal anti-inflammatory. SGTC_2425 5628681 7.85 µM -0.0306384214352664 0.447235034926429 no 1886 0.487778950324053 2482 5714958 SGTC_2845 9003024 42.97 µM -0.0307078187204326 0.447208848735071 no 1887 0.48775127783362 2495 2990173 SGTC_3351 9150312 21.596 µM -0.0310201209847234 0.447091008259497 no 1888 0.48762674658404 2457 4904905 SGTC_3229 9132204 49.47 µM -0.0321533853315004 0.446663434878298 no 1889 0.487174865027951 2459 17682924 SGTC_1678 st019265 80.2 µM -0.0327870720609773 0.446424375927179 no 1890 0.486922193835982 2465 5367020 SGTC_2862 9027634 71.43 µM -0.0330704827983431 0.446317465239786 no 1891 0.486809190592072 2460 5012562 SGTC_217 ketoconazole 989 nM -0.0334409490105935 0.44617772060707 no 1892 0.486661477660992 2452 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4 SGTC_2688 kanamycin b 96.69 µM -0.0334417063822978 0.446177434923537 no 1893 0.486661175682299 2476 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis. SGTC_1262 0737-0114 49.6 µM -0.0338421733521252 0.446026381152287 no 1894 0.486501502860031 2461 765919 SGTC_3053 9095903 49.47 µM -0.0340384111913957 0.445952364258851 no 1895 0.4864232603675 2470 17174018 SGTC_1057 3448-5381 134 µM -0.0348210498003575 0.445657187766233 no 1896 0.486111217747541 2499 5497911 SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM -0.0348354546825115 0.445651755166813 no 1897 0.486105474515353 2472 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair. SGTC_2386 9075165 157.42 µM -0.0355170146014075 0.445394726076688 no 1898 0.485833739622311 2481 16452277 SGTC_1437 4092-1038 11.6 µM -0.0355759122835959 0.445372515726572 no 1899 0.485810257686672 2469 3977136 SGTC_2180 6301957 200 µM -0.0358478088205526 0.445269985608628 no 1900 0.485701855809025 2471 845462 SGTC_1274 0865-0114 173 µM -0.0371611854316707 0.444774772940882 no 1901 0.485178243379903 2499 870624 SGTC_3330 9141424 71.43 µM -0.037335688583857 0.444708982462996 no 1902 0.485108674972471 2485 27261020 SGTC_1053 3366-3204 134 µM -0.0374540090105753 0.444664374637121 no 1903 0.485061504943866 2494 3632071 YPR165W RHO1 SGTC_339 3091-4833 71.4 µM -0.0386711428810779 0.444205545408075 no 1904 0.484576290418897 2497 3240077 SGTC_509 pifithrin 175 µM -0.0399702176720673 0.443715908987864 no 1905 0.484058435082717 2477 4817 A p53 inhibitor. SGTC_3091 9116372 49.47 µM -0.0403302517949357 0.443580223105837 no 1906 0.483914917973881 2602 17169793 SGTC_2226 7298446 200 µM -0.0408303725361875 0.443391753827943 no 1907 0.483715562879732 2486 3283010 SGTC_1487 3970-0795 2.82 µM -0.041302974424272 0.443213666729303 no 1908 0.483527180923938 2509 3765103 SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM -0.0415787122170016 0.443109767777976 no 1909 0.483417271876786 2468 66535 A nucleotide analog. SGTC_946 3434-1334 87.4 µM -0.0421487353407451 0.442894993508167 no 1910 0.483190064740611 2524 4047976 SGTC_1253 0550-0034 176 µM -0.0431113431504432 0.442532338645014 no 1911 0.482806388590337 2528 5969915 SGTC_1181 1222-0449 220 µM -0.0445320650727955 0.441997180979607 no 1912 0.482240146544616 2513 658318 SGTC_830 4076-0286 57.8 µM -0.0459135037179284 0.441476922029213 no 1913 0.481689595558926 2505 6866659 SGTC_1525 8-methoxypsoralen 92.5 µM -0.0461083550845911 0.441403547816834 no 1914 0.481611943349093 2501 4114 Related to psoralen; DNA damaging agent. SGTC_1004 4084-0029 199 µM -0.0483751376291621 0.440550105185638 no 1915 0.480708636699411 2513 716894 YLR208W SEC13 SGTC_2742 clothiapine 36.27 µM -0.048527343127457 0.440492809729723 no 1916 0.480647986721285 2492 16351 An atypical antipsychotic. YIL048W NEO1 SGTC_2393 9031399 185.94 µM -0.0487931567917277 0.440392751187901 no 1917 0.480542067884836 2526 1526623 YDL150W RPC53 SGTC_2133 5320837 200 µM -0.0502082674119195 0.439860134344792 no 1918 0.479978211711508 2541 2841355 SGTC_2756 carbadox 75.1 µM -0.0503593279767996 0.439803284846938 no 1919 0.479918023405324 2524 2553 A substituted quinoxaline antibiotic. YLR208W SEC13 SGTC_408 cantharidin 100 µM -0.050886987107292 0.439604717575592 no 1920 0.479707787429926 2545 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_2684 capsaicin 100 µM -0.0515655551075925 0.439349383021629 no 1921 0.479437432925268 2549 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_3077 9117319 49.47 µM -0.0517855979665299 0.439266589738512 no 1922 0.479349765655505 2497 17154678 SGTC_2179 6298986 200 µM -0.0527397789325162 0.43890760057888 no 1923 0.478969622054039 2544 738374 SGTC_291 SEC14.278 35.5 µM -0.0534565036167089 0.438637982042935 no 1924 0.478684093076056 2493 1068044 SGTC_918 glabranin 770.725 nM -0.0538176743050409 0.438502127108667 no 1925 0.478540213933384 2534 124049 Also referred to as licorice root. SGTC_475 α-linolenic acid 10 µM -0.0544491712921825 0.438264605923398 no 1926 0.478288651951676 2612 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_2526 patulin 37.61 µM -0.0553017312655355 0.437943972929753 no 1927 0.477949041464244 2557 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.  SGTC_1502 4534-4282 27.7 µM -0.0578995821123231 0.436967218414806 no 1928 0.476914307995798 2526 3278949 SGTC_846 0335-0850 148 µM -0.0580880389569569 0.436896376226448 no 1929 0.476839250917802 2509 6819598 SGTC_622 1348-1566 26.3 µM -0.0582650431837291 0.436829840996503 no 1930 0.476768755844659 2570 7340407 SGTC_1880 MG-132 525 µM -0.0584331732419395 0.436766643188227 no 1931 0.47670179573979 2541 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1 SGTC_94 0334-0113 514.748 µM -0.0584665600860098 0.436754093718419 no 1932 0.476688499048813 2510 6795178 SGTC_1602 st001878 87.6 µM -0.0585076051052141 0.436738665775723 no 1933 0.47667215243792 2674 595405 YLR310C CDC25 SGTC_779 1360-0071 233 µM -0.0587837584984077 0.436634868138718 no 1934 0.4765621724645 2596 7566 SGTC_1651 st011928 86.1 µM -0.0594430895544767 0.4363870633619 no 1935 0.476299596607347 2582 720198 SGTC_2935 9038016 29.96 µM -0.059986138625499 0.436182981066772 no 1936 0.476083337291695 2518 6463195 SGTC_2762 leflunomide 42.06 µM -0.0600342314189527 0.436164908218627 no 1937 0.476064185558895 2522 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1 SGTC_2335 9018011 154.17 µM -0.0609139758084183 0.435834331582229 no 1938 0.475713859515007 2599 6458208 SGTC_1894 3',6'-dihydroxyflavone 78.7 µM -0.0612092863954884 0.435723374409593 no 1939 0.475596267063939 2512 688662 SGTC_2211 7117706 200 µM -0.0613930680792301 0.435654324592839 no 1940 0.475523086409678 2509 822771 SGTC_2301 7769476 200 µM -0.0617663949091908 0.435514065572893 no 1941 0.475374432673221 2552 977820 SGTC_1614 st002383 48.6 µM -0.0617820606495826 0.435508180125989 no 1942 0.475368194860306 2513 1947235 SGTC_1831 st055328 12 µM -0.062329269079663 0.435302608891615 no 1943 0.475150310214811 2529 1103068 SGTC_1046 2001-0062 216 µM -0.0645783437105318 0.434457877290323 no 1944 0.474254863962865 2531 739778 SGTC_2829 7992743 58.44 µM -0.0679050850027668 0.433208933653868 no 1945 0.47293059542612 2547 16462845 SGTC_2409 alverine citrate 63.97 µM -0.0684861096597806 0.432990870205425 no 1946 0.472699338499726 2816 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM -0.0692367798514972 0.432709167575653 no 1947 0.472400573625379 2564 6857784 SGTC_520 3584-0023 682 µM -0.0696335975226192 0.432560268341313 no 1948 0.472242647439474 2618 1340790 SGTC_2859 9028643 45.46 µM -0.0704668337161888 0.432247641502341 no 1949 0.471911048883234 2621 17151580 SGTC_834 0312-0008 75.7 µM -0.0727148748502605 0.43140439772154 no 1950 0.471016505733242 2528 6385573 YIL048W NEO1 SGTC_2002 4023503 131 µM -0.0727864959321549 0.431377537657378 no 1951 0.470988008568318 2523 4736863 YCR052W RSC6 SGTC_1687 st020778 55.3625 µM -0.0747329589773552 0.43064767726127 no 1952 0.470213591758431 2549 4259299 SGTC_998 3996-0085 177 µM -0.0750725064123326 0.430520382196044 no 1953 0.470078511391801 2581 715391 SGTC_585 0kpi-0023 191 µM -0.0751481312678395 0.430492031702728 no 1954 0.47004842642238 2566 64601 SGTC_2104 5389443 200 µM -0.0756970407908621 0.430286265450865 no 1955 0.469830065173609 2638 2244536 SGTC_2187 6125751 200 µM -0.0764265357238439 0.430012833589289 no 1956 0.469539879442815 2574 874498 SGTC_1233 0325-0408 14.2 µM -0.0789086959755461 0.429082713683436 no 1957 0.468552623211844 2620 12874 SGTC_1304 1165-0502 251 µM -0.0790274716873878 0.429038215646193 no 1958 0.468505386072801 2578 767425 SGTC_2906 7926292 26.41 µM -0.0794545143050766 0.42887823619715 no 1959 0.468335554753128 2614 2966319 SGTC_1906 st060206 94.7 µM -0.0802811965038083 0.428568576295551 no 1960 0.468006806476776 2528 5133468 SGTC_2348 9022543 33.42 µM -0.0808921680455203 0.428339745873197 no 1961 0.467763854274346 2627 3162678 YDL140C RPO21 SGTC_3349 9149703 23.001 µM -0.0823992750468603 0.427775384239438 no 1962 0.467164606259938 2531 4910494 SGTC_672 1441-0018 53.7 µM -0.0824642178631973 0.427751068618499 no 1963 0.467138785699152 2558 251141 SGTC_772 k072-0172 35.3 µM -0.0841804566599078 0.427108581298537 no 1964 0.466456478177133 2578 5861980 SGTC_807 1315-0151 48 µM -0.0842309526839698 0.427089680638976 no 1965 0.466436404471763 2555 4011080 SGTC_3025 9087895 49.47 µM -0.0843201777544542 0.427056284108252 no 1966 0.466400935001271 2579 17173641 SGTC_1871 st057448 67.3 µM -0.0871401191265149 0.426001063711067 no 1967 0.465280068101678 2650 691747 SGTC_1295 1013-0063 9.78 µM -0.0880954127183757 0.425643713136942 no 1968 0.464900421163081 2569 6826038 SGTC_2353 9059630 146.67 µM -0.0895588856269246 0.425096384378394 no 1969 0.464318878787844 2643 4779114 SGTC_1833 st055984 71 µM -0.0913925400646842 0.424410814130794 no 1970 0.463590344554833 2609 676288 SGTC_3242 9133940 49.47 µM -0.0916101824068765 0.42432945673208 no 1971 0.463503880541321 2716 17248444 SGTC_2492 derrusnin 100 µM -0.0923936418023529 0.424036616639713 no 1972 0.463192645464261 2543 1715307 Part of coumarin class of compounds. SGTC_647 0140-0236 81 µM -0.0945598844082869 0.423227141008348 no 1973 0.462332207304085 2613 990837 SGTC_1384 3089-0840 101 µM -0.097426364456962 0.422156501051956 no 1974 0.461193904254072 2569 1069836 SGTC_1934 st074720 32.6 µM -0.0975439914985696 0.422112579183305 no 1975 0.461147200304193 2582 17250992 SGTC_1700 st030840 7.9285 µM -0.0986680388823945 0.421692909479124 no 1976 0.460700923139037 2680 5499307 SGTC_331 k048-0133 24.5 µM -0.10048250543138 0.42101565553614 no 1977 0.459980635590926 2573 6813582 SGTC_862 0452-0056 10.2 µM -0.10151768351654 0.420629377410918 no 1978 0.459569760330049 2591 1575396 YLR359W | YHR072W ADE13 | ERG7 SGTC_2868 9035608 32.47 µM -0.103346142603636 0.419947272297644 no 1979 0.458844127572847 2550 6462614 SGTC_538 2922-0838 53.3 µM -0.105860271714419 0.419009771479156 no 1980 0.457846607735749 2589 777039 SGTC_1859 st055998 20 µM -0.107001043297794 0.418584537181045 no 1981 0.457394076038107 2598 676301 SGTC_763 3453-1109 128 µM -0.107026781938027 0.418574943934589 no 1982 0.457383866434047 2586 1560353 SGTC_2253 7938677 135.83 µM -0.110028232406243 0.417456583815112 no 1983 0.456193492310585 2801 2301972 SGTC_1999 st074831 12.5 µM -0.110350774442872 0.417336442091439 no 1984 0.45606559546143 2630 17112523 SGTC_2066 5222451 176 µM -0.111425646383148 0.416936125344052 no 1985 0.455639411908119 2595 2281147 SGTC_1273 0849-0096 14.1 µM -0.112199165937682 0.416648095135469 no 1986 0.455332745240227 2633 5286025 SGTC_108 0509-0257 621.132 µM -0.113459415576412 0.41617892045868 no 1987 0.454833168468549 2693 536624 SGTC_925 2064-1272 59.6 µM -0.113575607549822 0.416135669688957 no 1988 0.454787112280983 2642 6815817 SGTC_597 k018-0003 82.8 µM -0.113582109114553 0.416133249606182 no 1989 0.45478453520797 2713 6786234 SGTC_139 0099-0334 718.624 µM -0.113737677560009 0.41607534318462 no 1990 0.454722871967273 2606 97690 SGTC_1928 4'-methoxychalcone 40.3 µM -0.114141840782377 0.415924912158736 no 1991 0.454562677397446 2805 641818 SGTC_1316 1272-0050 65.9 µM -0.115866511692804 0.415283122046431 no 1992 0.45387916834596 2617 7340392 SGTC_1436 4092-1007 8.32 µM -0.116997881781001 0.414862235581466 no 1993 0.453430866023986 2629 2881121 SGTC_2534 helenine 20.12 µM -0.117188005650913 0.414791516256258 no 1994 0.4533555357655 2621 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58 SGTC_1421 4029-0249 71.4 µM -0.11772491004656 0.414591821812315 no 1995 0.453142814331176 2713 2894095 SGTC_913 3487-1245 167 µM -0.11812114715579 0.414444460845476 no 1996 0.452985833872157 2605 4016153 SGTC_3335 9143315 29.6265 µM -0.119469152586712 0.413943226596389 no 1997 0.452451838822468 2695 4899691 SGTC_179 1273-0063 6.77 µM -0.119749529579782 0.413838990478829 no 1998 0.452340781846377 2631 3108139 SGTC_2541 muurolladie-3-one 83.07 µM -0.120245270067223 0.413654703255874 no 1999 0.452144428789833 2794 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils.  YMR203W TOM40 SGTC_2911 7942208 15.64 µM -0.121597857932415 0.413151987297987 no 2000 0.45160875501165 2702 1243384 SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM -0.123263010359635 0.412533296149775 no 2001 0.450949415434411 2612 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1 SGTC_220 paclitaxel 373.376 µM -0.123777215223879 0.412342286002407 no 2002 0.450745836339646 2744 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_421 streptovitacin 30 mM -0.123832344202562 0.412321808636526 no 2003 0.450724010967308 2820 91467 include heat shock SGTC_1779 st039427 55 µM -0.12384358363841 0.412317633837156 no 2004 0.450719561331741 2615 1124498 SGTC_297 0986-0032 24 µM -0.123984960526618 0.412265121359915 no 2005 0.450663591468865 2619 2847425 SGTC_367 0335-0881 7.1 µM -0.124102976392744 0.412221287211927 no 2006 0.450616870779797 2731 23828853 SGTC_1372 2752-0194 270 µM -0.12491248536007 0.411920644167837 no 2007 0.450296416951965 2623 823334 SGTC_2107 5363541 170.161 µM -0.125043590616417 0.411871957925565 no 2008 0.450244520408127 2629 244052 SGTC_2940 9060638 45.86 µM -0.125882732444565 0.411560372813028 no 2009 0.449912375723211 2717 4027022 SGTC_467 ro 31-8220 72.8 µM -0.126066874827842 0.411492005621857 no 2010 0.449839494144074 2719 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7 SGTC_303 1348-1668 34.2 µM -0.126193390159904 0.411445035386248 no 2011 0.449789421713741 2666 5380509 SGTC_1202 1988-0068 29.6 µM -0.127123448998471 0.411099779615736 no 2012 0.449421346204554 2639 2850480 SGTC_14 0354-0009 295 µM -0.128123367198451 0.410728667509113 no 2013 0.449025672048502 2603 1713507 SGTC_1783 st039459 87.517 µM -0.12821368064633 0.410695152282732 no 2014 0.448989936917915 2863 729761 SGTC_1931 st074438 57.1 µM -0.128821341668231 0.41046966687532 no 2015 0.448749509012975 2586 2787313 SGTC_3061 glucosamine 200 µM -0.128845529047015 0.410460692251389 no 2016 0.448739939393915 2613 91431 and experimental redox chemotherapeutic SGTC_1960 st011366 51.8 µM -0.129013021602724 0.41039854613837 no 2017 0.448673672595522 2618 3972846 SGTC_1443 4112-3303 14 µM -0.129679710159141 0.41015120162468 no 2018 0.448409917972584 2649 704433 SGTC_3309 9129340 25.759 µM -0.131442747872331 0.409497279021652 no 2019 0.447712537038093 2704 17158987 SGTC_1069 diphenylcyclopropenone 8.49 µM -0.132403158936117 0.409141161856081 no 2020 0.447332708103032 2653 65057 A dermal irritant. YDR527W RBA50 SGTC_1630 st005209 31.3 µM -0.133274607434977 0.408818096578879 no 2021 0.446988104382861 2617 3367314 SGTC_1676 st018489 23.4 µM -0.134657500473772 0.408305554691589 no 2022 0.446441338381516 2713 3696235 SGTC_2738 aclarubicin 5.55 µM -0.13824955711978 0.406974964919376 no 2023 0.445021595086961 2730 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31 SGTC_361 000s-0510 1.45 µM -0.138739395495576 0.406793599037198 no 2024 0.444828043013766 2730 660 SGTC_650 1328-0195 38 µM -0.138829097990866 0.406760388262234 no 2025 0.444792599880944 2642 2780821 SGTC_1493 4348-0038 111 µM -0.1396079596057 0.406472056626894 no 2026 0.444484875680691 2662 800424 SGTC_1662 st014054 52 µM -0.139864540260566 0.406377082530427 no 2027 0.444383509307235 2626 2838777 SGTC_1091 telmisartan 47.6 µM -0.140016989167284 0.406320655719929 no 2028 0.444323283601965 2749 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension. SGTC_2702 st077768 96.8 µM -0.140473627098819 0.406151649282346 no 2029 0.44414289419439 2736 6484119 SGTC_1642 st009582 77.7 µM -0.142612987271379 0.40536008323325 no 2030 0.443297919985781 2732 6739311 SGTC_3315 9136395 68.55 µM -0.143253276699355 0.405123250397561 no 2031 0.443045077473123 2670 16876844 SGTC_715 0868-0130 184 µM -0.144293147092878 0.404738693005637 no 2032 0.44263449475384 2759 2876258 SGTC_2084 5306078 60.6385 µM -0.145154938511767 0.404420061191148 no 2033 0.442294271449277 2742 679340 SGTC_2890 9046729 58.44 µM -0.146550446090836 0.403904231970301 no 2034 0.441743434764425 2709 903329 SGTC_1256 0570-0116 285 µM -0.147691544867006 0.403482565401795 no 2035 0.441293102337743 2698 410638 SGTC_1403 3909-7815 62.9 µM -0.147723175683091 0.403470878563425 no 2036 0.441280620375612 2645 6615483 SGTC_1946 st076057 65.1 µM -0.148119869069761 0.403324317062881 no 2037 0.441124084577068 2662 953009 SGTC_2295 7971645 200 µM -0.1483743658898 0.403230298353649 no 2038 0.441023664596087 2753 2978226 YKL099C UTP11 SGTC_2021 4019055 173 µM -0.149036351547949 0.402985767335196 no 2039 0.440762474442892 2777 44827708 YER133W GLC7 SGTC_1711 st032263 62.8 µM -0.149214763821331 0.402919870075071 no 2040 0.440692085283578 2713 3958979 SGTC_403 arphamenine a 50 µM -0.149731545025459 0.402729010514819 no 2041 0.440488209699452 2672 5487158 An arginine aminopeptidase inhibitor. SGTC_107 0358-0022 2.6945 µM -0.15232869181287 0.40177017441905 no 2042 0.439463848091732 2749 521106 YGL093W | YPR107C SPC105 | YTH1 SGTC_2654 protoveratrine a 100 µM -0.152931667855073 0.401547647068261 no 2043 0.43922608115629 2678 5702278 A heart drug and vasodilator. SGTC_2879 9041815 71.43 µM -0.153398493642978 0.40137538767307 no 2044 0.439042016363593 2673 4942971 SGTC_847 0342-0274 5.54 µM -0.153521349936819 0.401330056706218 no 2045 0.438993577530824 2789 18097 SGTC_172 1112-0046 2.638 µM -0.154237148594463 0.401065970940799 no 2046 0.438711376143 2740 2802135 YIL048W NEO1 SGTC_306 1672-3436 11.6 µM -0.15499127911476 0.400787791964903 no 2047 0.438414096241891 2775 6797378 SGTC_1174 0739-0097 51.1 µM -0.155124100273101 0.400738802928133 no 2048 0.438361741444611 2737 728447 SGTC_3124 9127567 49.47 µM -0.155494268598544 0.400602280287879 no 2049 0.438215835992207 2849 17592030 SGTC_1117 retinoic acid 1.10837 µM -0.155774530797365 0.400498924210307 no 2050 0.43810537350072 2829 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR). SGTC_1100 amiodarone 5.07 µM -0.156544085643384 0.400215160921052 no 2051 0.437802086121113 2776 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. SGTC_2444 5485484 36.41 µM -0.156721245301896 0.400149843065924 no 2052 0.437732271328138 2797 6790631 SGTC_739 1486-1183 203 µM -0.157897591805003 0.399716201088561 no 2053 0.437268747860754 2716 4346692 SGTC_882 0843-0131 351 µM -0.158303430434297 0.399566623607542 no 2054 0.437108852566501 2671 5425421 SGTC_1945 st075991 56.6 µM -0.158591598943275 0.399460424036011 no 2055 0.436995324048462 2740 1084980 SGTC_1725 st036284 20.55 µM -0.159009383034308 0.399306470072354 no 2056 0.436830740648533 2931 707914 SGTC_2681 menadione 3.18 µM -0.159152562452799 0.399253711877879 no 2057 0.436774338536421 2736 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_394 menadione 8.33 µM -0.160923299881788 0.398601389827163 no 2058 0.436076905408508 2680 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_2927 9011802 47.9 µM -0.161580430542515 0.398359381378835 no 2059 0.435818134475779 2797 43912568 SGTC_373 0844-0104 25.9 µM -0.163366721120201 0.397701723075771 no 2060 0.435114851770914 2798 5375804 SGTC_2050 5263056 171 µM -0.163458986494817 0.397667761625737 no 2061 0.435078531409025 2805 763468 YGL055W OLE1 SGTC_3137 9097352 49.47 µM -0.164095638904757 0.39743344092334 no 2062 0.434827927463753 2994 44120435 SGTC_774 k060-0086 136 µM -0.164202586544167 0.397394082341422 no 2063 0.434785832489208 2681 5911235 SGTC_2213 7173844 200 µM -0.165462994848655 0.39693030908431 no 2064 0.434289787078396 2717 892728 SGTC_2809 7964133 12.99 µM -0.166601394978562 0.396511554548327 no 2065 0.4338418480032 2758 1253665 SGTC_187 1488-2104 32.728 µM -0.16682380810554 0.396429754963291 no 2066 0.43375434251586 2770 2852859 SGTC_871 0574-0004 149 µM -0.167335655854241 0.396241523804452 no 2067 0.433552975165696 2707 9551173 SGTC_1571 st070080 73.4 µM -0.167617997767848 0.396137703382216 no 2068 0.433441905678535 2839 4315245 SGTC_1813 st051246 8.6015 µM -0.168453576547985 0.395830494480274 no 2069 0.433113231125645 2736 5291959 SGTC_3012 9080433 71.4286 µM -0.168917871084986 0.395659819896762 no 2070 0.432930621049124 2736 17688859 SGTC_1229 0139-0193 12.2 µM -0.169459745993326 0.395460652085554 no 2071 0.432717516218578 2810 3090752 SGTC_2827 7993847 71.43 µM -0.169625484536954 0.395399739817066 no 2072 0.432652339611019 2816 2985692 SGTC_1882 5615643 20 µM -0.170150294140338 0.395206878531806 no 2073 0.432445970566393 2672 2253075 SGTC_327 1273-0057 3.96 µM -0.171265432255985 0.394797163809014 no 2074 0.432007529950988 2765 3108138 SGTC_1868 st057644 42.7 µM -0.171954856072569 0.394543919631857 no 2075 0.431736509948764 2696 688665 SGTC_3021 9087658 49.47 µM -0.171954988114587 0.394543871133486 no 2076 0.431736458044684 2731 25237042 SGTC_2871 9038510 12.99 µM -0.172441955523644 0.394365021571559 no 2077 0.431545045216563 2727 4945164 SGTC_1184 1269-1718 139 µM -0.174287242177267 0.393687501558986 no 2078 0.430819862533801 2858 5403821 SGTC_1501 4491-0275 38.4 µM -0.174332807880797 0.393670775604395 no 2079 0.43080195852233 2710 5104718 SGTC_3127 9126946 49.47 µM -0.174569706817634 0.393583819484479 no 2080 0.4307088767418 2812 27243249 SGTC_604 1000-0114 314 µM -0.176954468570004 0.392708765168642 no 2081 0.429772076954189 2850 1572745 SGTC_203 k066-0004 30.888 µM -0.177297905300783 0.392582790505626 no 2082 0.429637198029238 2686 6795412 SGTC_3239 9133757 49.47 µM -0.177586327960223 0.392477004028587 no 2083 0.429523931287554 2712 17036923 SGTC_485 niflumic acid 177 µM -0.178821467514177 0.39202407456553 no 2084 0.429038944168227 2835 4488 A COX2 inhibitor. SGTC_2268 7933382 153.85 µM -0.179137679298827 0.391908142227374 no 2085 0.428914798351931 2687 935025 YOR257W CDC31 SGTC_755 1995-0008 37.3 µM -0.179401482798351 0.391811431616517 no 2086 0.428811233585599 2708 689533 SGTC_3346 9158254 43.5805 µM -0.180981731803209 0.391232250999565 no 2087 0.428190957567119 2821 17639500 SGTC_608 k048-0125 159 µM -0.18147474629763 0.391051604431957 no 2088 0.427997476784338 2817 6817652 YLR060W | YFL022C FRS1 | FRS2 SGTC_2828 7998861 71.43 µM -0.181529120705945 0.391031682419083 no 2089 0.427976138910706 2797 2988188 SGTC_1846 st056244 14.8 µM -0.182126579273889 0.390812800906834 no 2090 0.427741695155806 2795 5393182 SGTC_2955 9076254 12.21 µM -0.182838985741174 0.390551852952943 no 2091 0.427462179000143 2801 16459619 SGTC_2737 bleomycin 30.5 nM -0.182962032151051 0.39050678717032 no 2092 0.427413904823705 2742 16211318 Bleomycin acts by induction of DNA strand breaks. SGTC_1664 st014217 9.02 µM -0.184475280738067 0.389952679902487 no 2093 0.426820308734675 2741 3982782 SGTC_2095 5432005 200 µM -0.184534363910882 0.389931049904141 no 2094 0.42679713576239 2760 783734 SGTC_2052 5265182 7.135 µM -0.186367625282391 0.389260073487266 no 2095 0.426078239457695 2866 1239884 SGTC_3285 9112818 20.8695 µM -0.186636133591753 0.389161826706397 no 2096 0.425972966997408 2719 17017947 YPR165W RHO1 SGTC_351 caspofungin 25 nM -0.187145129237173 0.388975605428214 no 2097 0.425773422578309 2767 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1 SGTC_893 0958-0369 48.9 µM -0.187830217657283 0.388724999073066 no 2098 0.425504873537538 2890 6819948 SGTC_3047 9092122 49.47 µM -0.1882794089303 0.388560709367268 no 2099 0.425328812991559 2796 17173831 SGTC_37 0566-0070 1.56 µM -0.189792803395084 0.388007338953684 no 2100 0.424735747729597 2850 1626686 SGTC_2775 cyproheptadine 69.59 µM -0.19090058930264 0.387602422734389 no 2101 0.424301739233782 2768 2913 A selective serotonin reuptake inhibitor. SGTC_1653 st012112 65 µM -0.193927052889832 0.386496818617415 no 2102 0.423116500325114 2907 720429 SGTC_723 4182-0001 115 µM -0.194062115941457 0.386447499831479 no 2103 0.4230636223853 2769 744821 YLR208W SEC13 SGTC_1027 k015-0025 8.67 µM -0.195204230430638 0.386030525802386 no 2104 0.422616533681753 2731 3598955 SGTC_2402 5553605 200 µM -0.19527896717876 0.386003244782171 no 2105 0.422587280927272 2928 6758546 SGTC_2473 5854593 8.94 µM -0.195559381431438 0.385900890700327 no 2106 0.422477527627202 2702 2872951 SGTC_1608 st001473 40.5 µM -0.196251462297093 0.385648308082921 no 2107 0.422206675020255 2746 7292267 SGTC_1355 1499-0035 1.68 µM -0.196858940219585 0.385426642201986 no 2108 0.421968962912209 2761 1548538 SGTC_8 0354-0001 70 µM -0.197287193969025 0.385270396876953 no 2109 0.42180140007055 2755 4993152 SGTC_740 k014-0057 261 µM -0.197447150176289 0.385212042771238 no 2110 0.421738817636116 2867 4012779 SGTC_1112 tnp00069 1.16933 µM -0.198228138862352 0.384927165284477 no 2111 0.421433286332912 2873 145826 SGTC_417 st075190 100 µM -0.199064048918111 0.384622323206413 no 2112 0.421106321597596 2903 222757 SGTC_1883 5-benzylidenerhodanine 20 µM -0.199754033131985 0.384370751509016 no 2113 0.42083647647246 2876 1273210 SGTC_248 streptozotocin 5.23457 mM -0.200447789772863 0.384117853460687 no 2114 0.420565193488418 2848 5300 DNA alkylating agent. SGTC_1059 3448-6867 171 µM -0.200989787030747 0.383920311221886 no 2115 0.420353279944199 2716 3934407 SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM -0.201561500025421 0.383711971144233 no 2116 0.420129772969721 2799 2374 Ca(2+)-ATPase inhibitor. SGTC_269 exalamide 29 µM -0.202028016911107 0.383541990875857 no 2117 0.419947410716348 2792 3316 A derivative of salicylamide. SGTC_3325 9138760 55.175 µM -0.202381942568392 0.38341304933849 no 2118 0.419809072031248 2798 43844959 SGTC_382 3229-0966 23.2 µM -0.202750919148451 0.383278638224423 no 2119 0.419664860951879 2938 5722370 SGTC_1214 0358-0031 63.7 µM -0.203401955630456 0.383041512352472 no 2120 0.419410435693978 3053 4301366 SGTC_2676 harmalol 100 µM -0.204713465393433 0.3825639565995 no 2121 0.418897999672587 2811 5459187 A monoamine oxidase inhibitor SGTC_645 0845-0943 5.41 µM -0.205042722897652 0.382444093150243 no 2122 0.418769373015397 2810 1885106 SGTC_1291 0993-0025 5.79 µM -0.205498367580931 0.382278238080586 no 2123 0.418591386683085 2893 4353356 SGTC_3248 9135562 49.47 µM -0.209226281629742 0.380922087764148 no 2124 0.417135798327794 2814 17650701 SGTC_1423 4048-0112 5.59 µM -0.211032210735089 0.380265646575089 no 2125 0.416431068388218 2859 X1423 SGTC_2487 5918373 44.05 µM -0.211886978420292 0.379955065237837 no 2126 0.416097604834078 2775 2876279 SGTC_878 0828-0289 13.7 µM -0.21231874150116 0.379798212777658 no 2127 0.415929187562112 2810 745350 YLR208W SEC13 SGTC_51 1013-0126 23.419 µM -0.214243879227422 0.3790990827325 no 2128 0.415178439856302 3033 1627850 SGTC_2611 pyromycin 23.93 µM -0.216290240093115 0.378356362897946 no 2129 0.41438075814963 2825 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release. SGTC_2713 st079149 53.4 µM -0.216805013795887 0.378169598108828 no 2130 0.414180152224746 2869 3103253 SGTC_2736 butenafine 14.65 µM -0.216865947060863 0.378147492824722 no 2131 0.414156408176418 2818 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_3270 9137563 49.47 µM -0.217071189098767 0.378073038341987 no 2132 0.414076433204016 2909 17015724 SGTC_2396 5342950 42.78 µM -0.217800834280767 0.377808385803677 no 2133 0.413792147253393 2883 1886677 SGTC_380 3970-0968 6 µM -0.219095420624903 0.377338962387962 no 2134 0.413287858964743 2803 2891601 SGTC_346 4513-0042 7.16 µM -0.22180480640741 0.376357112785758 no 2135 0.41223291884139 2798 2827372 SGTC_2342 7990637 118.86 µM -0.223529599924977 0.375732483933656 no 2136 0.41156167422223 2917 2033102 YER133W GLC7 SGTC_1830 st055982 50.3 µM -0.225189089349016 0.375131811992061 no 2137 0.410916088463192 2801 455313 An antimicrobial agent. SGTC_3073 9114972 49.47 µM -0.227154489048199 0.374420803798878 no 2138 0.410151807566182 2924 41905075 SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM -0.227273625233714 0.374377718474155 no 2139 0.410105490263135 2932 5024745 SGTC_1581 himbacine 57.9 µM -0.227440766892629 0.374317274725811 no 2140 0.410040511692811 2803 5281825 An alkaloid muscarinic receptor antagonist. SGTC_50 0929-0078 56.389 µM -0.227449930404141 0.374313960997441 no 2141 0.41003694932574 2842 1377751 SGTC_584 0986-0246 15.4 µM -0.229027783029456 0.37374351323865 no 2142 0.409423661118352 2793 53315 YDR232W HEM1 SGTC_3236 9132701 49.47 µM -0.230053311828785 0.37337289761557 no 2143 0.409025171815575 2859 24282524 SGTC_76 0433-0009 400.328 µM -0.230396336418641 0.373248958154967 no 2144 0.408891903852341 2939 2841569 SGTC_2585 alliin 100 µM -0.230809485196456 0.37309969927859 no 2145 0.408731406030121 3021 87310 A garlic compound which reacts with lipids. SGTC_1704 st028805 70.8 µM -0.230942984705944 0.373051473781172 no 2146 0.408679548126693 2864 2876101 SGTC_3209 9113616 49.47 µM -0.231123859223019 0.372986137661432 no 2147 0.408609289945515 3001 16649353 SGTC_2008 4012253 172 µM -0.231866730592678 0.372717833421658 no 2148 0.408320762758851 2801 603940 SGTC_2967 9089538 49.85 µM -0.235581317338525 0.371377157807111 no 2149 0.406878786036339 3057 728216 SGTC_2371 9071574 200 µM -0.235684578107443 0.37133991093494 no 2150 0.406838718856184 2920 45596039 SGTC_131 0141-0277 33.849 µM -0.235759651937014 0.371312832042773 no 2151 0.406809589367077 2994 1547771 SGTC_803 4488-1585 147 µM -0.238280401088329 0.37040397636924 no 2152 0.405831810644872 2957 747204 SGTC_1322 1348-1070 12 µM -0.238559212142035 0.370303495402985 no 2153 0.405723697989671 2825 6758089 SGTC_2946 9065502 71.43 µM -0.239329990669004 0.370025759904083 no 2154 0.405424855913586 2836 16489101 SGTC_1611 st001856 99.4 µM -0.241400798874945 0.369279919209552 no 2155 0.404622246822631 2858 647478 SGTC_3036 9090181 49.47 µM -0.241480203983167 0.36925132973236 no 2156 0.404591478754286 2812 25236586 SGTC_1213 1315-0166 115 µM -0.242362219275271 0.368933812475763 no 2157 0.404249753216491 2947 768401 SGTC_1446 4239-0190 62 µM -0.24463528919885 0.368115941231574 no 2158 0.403369418646243 2856 1340085 SGTC_2375 9072683 200 µM -0.245554624196362 0.367785325589907 no 2159 0.403013509231793 2999 16798029 SGTC_2015 5119600 184 µM -0.246964865227677 0.367278358394593 no 2160 0.402467707723907 3030 2828786 SGTC_1915 st067105 30.6 µM -0.24708964994799 0.367233510691808 no 2161 0.402419421792247 2803 69751 YOR207C | YOR116C RET1 | RPO31 SGTC_1979 st071809 45.3 µM -0.247882977217722 0.366948430783831 no 2162 0.402112475576496 2977 4976333 SGTC_609 0986-0026 86.3 µM -0.248215361240743 0.366829011322652 no 2163 0.401983890820891 2863 2848610 SGTC_463 ikarugamyin 104 µM -0.248478152027867 0.366734604551672 no 2164 0.401882236134957 2848 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis. SGTC_2032 5185112 25.99 µM -0.252400290318775 0.365326549419745 no 2165 0.400365837883251 2923 5718189 SGTC_3043 9092303 49.47 µM -0.252724262129159 0.365210323744669 no 2166 0.400240648943009 2880 25236084 SGTC_1498 4478-3555 97.6 µM -0.254643967870537 0.364521878980255 no 2167 0.399499048433271 2863 3437919 SGTC_3347 9188721 44.724 µM -0.255956947983786 0.36405126948451 no 2168 0.398992040340323 2933 44118411 YKL104C | YBL026W GFA1 | LSM2 SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM -0.256171714425817 0.363974310555189 no 2169 0.398909124334641 2790 4000243 SGTC_163 TUB2.036 7.546 µM -0.259184807963153 0.362895184999903 no 2170 0.397746326096241 2962 15992207 YJR013W GPI14 SGTC_3183 9108214 49.47 µM -0.259573393350117 0.362756093948633 no 2171 0.397596431008562 2948 4974831 SGTC_2566 crystal violet carbinol 226 nM -0.26103209536232 0.36223412485146 no 2172 0.397033878256387 3026 68050 Cationic dye that binds acidic phospholipids including cardiolipin. SGTC_949 1165-0505 146 µM -0.262294278411745 0.361782682957086 no 2173 0.396547286410471 2888 6244267 SGTC_3264 9137442 49.47 µM -0.263319356324633 0.361416187328088 no 2174 0.396152220893986 3109 17015726 SGTC_2279 7948423 32.93 µM -0.263451717380274 0.361368873601998 no 2175 0.396101216644416 3090 1247112 SGTC_1866 st057638 64 µM -0.265600071955517 0.36060122064507 no 2176 0.395273615086975 2892 688802 SGTC_1877 wortmannin 25 µM -0.265775089044154 0.360538707993381 no 2177 0.395206214741819 3010 312145 A covalent inhibitor of PI 3-kinase. SGTC_2623 humulene 100 µM -0.266093242417658 0.360425079431095 no 2178 0.395083699610204 2963 6187145 An anti-inflammatory. SGTC_2823 7987624 58.44 µM -0.267436805716628 0.359945361478541 no 2179 0.394566432109687 3105 2239440 SGTC_262 fenpropimorph 62.5 µM -0.267742810767891 0.359836133480398 no 2180 0.394448647110747 2858 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_3119 9125183 49.47 µM -0.268089393249453 0.359712435259149 no 2181 0.394315255028851 2924 22695334 SGTC_3244 9134489 49.47 µM -0.26838896353408 0.359605527928361 no 2182 0.394199966907497 2942 16584271 SGTC_1855 st056195 39.6 µM -0.268713590856436 0.359489690922092 no 2183 0.394075046175465 3061 4028379 SGTC_3001 9076041 71.4286 µM -0.268903277410544 0.359422010904732 no 2184 0.39400205741428 2874 16004211 SGTC_1409 3909-8004 61.9 µM -0.269375884147926 0.359253404368033 no 2185 0.39382022107972 2916 2119279 SGTC_2397 5161689 200 µM -0.269562481857903 0.359186841567431 no 2186 0.393748433630335 3093 2259942 SGTC_787 4152-0075 138 µM -0.270330405855303 0.358912954103435 no 2187 0.393453037677531 2895 9566539 SGTC_198 3454-2873 16.191 µM -0.27318047873203 0.357897083254153 no 2188 0.39235724258918 2891 710957 SGTC_2225 6654152 15.4 µM -0.27339324438218 0.357821285994774 no 2189 0.392275472629371 2943 97582 YGR029W | YLR033W ERV1 | RSC58 SGTC_1694 st024011 44.9 µM -0.275114635695992 0.35720825078957 no 2190 0.391614083815895 2931 2787533 SGTC_1634 st006576 41 µM -0.275142677282593 0.357198267447915 no 2191 0.391603312332431 3082 3915356 SGTC_486 niguldipine 82 µM -0.27598749589234 0.356897541715635 no 2192 0.391278835116077 2880 1236 A calcium channel blocker. SGTC_83 0170-0301 39.027 µM -0.277678956778562 0.356295708437873 no 2193 0.390629407812337 2873 3089716 SGTC_2139 5578692 56.4705 µM -0.277723143438079 0.356279991312758 no 2194 0.39061244666203 2988 650991 YMR113W FOL3 SGTC_1656 st012921 11 µM -0.280975287938874 0.355123880492235 no 2195 0.3893646769922 3013 6732821 SGTC_188 3229-0966 278.469 µM -0.281538974988082 0.354923629537409 no 2196 0.389148519367007 2991 5722370 SGTC_1856 st057054 55.7 µM -0.28399186987751 0.354052700924075 no 2197 0.388208305575086 3144 1266018 SGTC_2780 5215298 71.43 µM -0.28511455559146 0.353654332657827 no 2198 0.387778189460675 3054 2834131 SGTC_1430 4049-0248 69.1 µM -0.285923640992982 0.35336734008843 no 2199 0.387468303196689 3034 22774488 SGTC_2570 licareol 100 µM -0.288547124504669 0.352437332205188 no 2200 0.386463981745636 2991 443158 SGTC_2722 naftopidil 47.16 µM -0.290607555182375 0.351707540568848 no 2201 0.385675740577756 3010 4418 An a1-adrenergic receptor antagonist or alpha blocker.  SGTC_23 0213-0011 39.996 µM -0.290695387643489 0.351676442979145 no 2202 0.385642149735549 3083 627608 SGTC_1810 st050138 53 µM -0.291741389923264 0.351306176175881 no 2203 0.385242180283534 3031 3444541 SGTC_801 0866-0028 10.1 µM -0.292581324775987 0.351008955801378 no 2204 0.38492109504031 2885 6849771 SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM -0.293858814034467 0.350557076641317 no 2205 0.384432895452379 2971 17037758 SGTC_1330 1469-0054 61.8 µM -0.294997438985624 0.350154495316887 no 2206 0.383997918047564 3068 7102664 SGTC_1249 0481-0015 10.2 µM -0.295278471261837 0.35005515718611 no 2207 0.383890580579097 2887 4227577 SGTC_1122 capsaicin 818.572 nM -0.296938264781272 0.349468669656207 no 2208 0.383256820938361 3064 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_851 0394-0702 453 µM -0.297226083664898 0.349367005444892 no 2209 0.383146954661591 3062 762646 SGTC_88 0180-0332 8.668 µM -0.298680295785998 0.348853509826041 no 2210 0.38259199642014 2895 3101745 SGTC_2186 6124449 200 µM -0.299028994503544 0.348730422210684 no 2211 0.382458961361993 3085 3834182 YLR033W RSC58 SGTC_1904 st060225 78 µM -0.300876602361092 0.348078498635834 no 2212 0.381754296351052 2941 66595 SGTC_2563 tomatine 8.54 µM -0.302502583603185 0.34750514654869 no 2213 0.381134482114166 3121 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties. SGTC_1935 st074532 41.6 µM -0.302959178892465 0.347344204967082 no 2214 0.380960485492595 3053 2829742 SGTC_989 1501-0895 10.3 µM -0.303202450850367 0.347258467237288 no 2215 0.380867790684793 3036 2830112 SGTC_929 2805-0021 398 µM -0.304543914601733 0.346785827968009 no 2216 0.380356770754651 3018 3098024 SGTC_2435 5706476 10.6 µM -0.305662164143842 0.346392016089761 no 2217 0.379930941983392 3087 5725375 SGTC_2182 6325192 200 µM -0.305976589435404 0.346281315395118 no 2218 0.379811235207449 2955 736248 SGTC_1118 chelidonine 707.474 nM -0.307033129883552 0.34590943214118 no 2219 0.379409077655737 3075 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor. SGTC_1432 4049-0298 68.4 µM -0.307242333150355 0.345835813963157 no 2220 0.379329462774957 3054 741646 SGTC_123 0083-0120 66.675 µM -0.307348304635703 0.345798525049825 no 2221 0.379289135972888 2964 16001701 SGTC_2511 berberine 10.47 µM -0.310113216226458 0.344826146211739 no 2222 0.378237431140404 2963 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_3102 9121669 49.47 µM -0.310550057168461 0.344672609181112 no 2223 0.378071349787013 2969 41905072 SGTC_758 0868-0029 16 µM -0.311367497309344 0.344385371215412 no 2224 0.377760630018841 3070 762687 SGTC_1874 staurosporine 7.6 µM -0.312000408131305 0.344163036102082 no 2225 0.377520106581063 3075 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1 SGTC_2004 4023728 41.89 µM -0.313653049806036 0.343582734027053 no 2226 0.376892281631689 3119 360084 YDR527W RBA50 SGTC_138 0850-0259 40.9225 µM -0.314669934932433 0.343225852001079 no 2227 0.376506136942151 3040 6813004 SGTC_1991 st073000 8.92 µM -0.317450114212794 0.342250845385421 no 2228 0.375451043195564 3156 4301969 YIL048W NEO1 SGTC_1402 3909-7673 35.9 µM -0.320187676497915 0.341291810883171 no 2229 0.374413032291366 2911 5328014 SGTC_3049 9092223 49.47 µM -0.322989977414708 0.340311157444608 no 2230 0.373351416241652 3069 8623917 SGTC_488 nitrendipine 139 µM -0.324629712669175 0.339737838892869 no 2231 0.372730668344852 2974 4507 Dihydropyridine L-type calcium channel blocker. SGTC_535 2293-4129 48.2 µM -0.326779444924954 0.338986766000142 no 2232 0.371917353628592 3145 396118 YIL048W NEO1 SGTC_1386 3228-0095 33.8 µM -0.326935071283206 0.338932418094397 no 2233 0.37185849716689 3114 870181 SGTC_453 enantio-paf c16 10 µM -0.327901002347983 0.338595170232675 no 2234 0.37149325791743 3092 13871343 A lipid and platelet activating factor SGTC_3296 9122258 64.045 µM -0.328514037781064 0.338381200431116 no 2235 0.371261516052345 3067 4730474 SGTC_2310 7668677 200 µM -0.328984626560174 0.338216984653788 no 2236 0.371083654041607 3204 2197143 SGTC_2233 sulbentine 40.3845 µM -0.329172369476459 0.338151478823403 no 2237 0.371012703098436 3037 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58 SGTC_1246 0422-0085 105 µM -0.329184903053667 0.338147105877411 no 2238 0.371007966622437 3133 264295 SGTC_404 fumagillin 50 µM -0.329523385257864 0.338029018211408 no 2239 0.370880060585893 3049 12015870 A methionine aminopeptidase binder. SGTC_836 0330-0104 1.35 µM -0.330542188126189 0.337673680512165 no 2240 0.370495160352521 2998 46494820 SGTC_1900 st060200 72.8 µM -0.331340778302388 0.33739524963188 no 2241 0.3701935463074 2963 688945 SGTC_1325 1431-0015 227 µM -0.331543232076031 0.337324677648829 no 2242 0.370117095603011 2987 1103340 SGTC_2503 beta-caryophyllene alcohol 24.72 µM -0.332601422869416 0.336955903298894 no 2243 0.369717584586682 3117 61125 An anti-inflammatory. SGTC_222 nsc-310342 10.666 µM -0.33263052282664 0.336945764316951 no 2244 0.369706600127433 3078 432556 SGTC_1625 st003711 30.1 µM -0.332632792947221 0.336944973368482 no 2245 0.369705743221812 3198 24207034 YER133W GLC7 SGTC_716 1683-5115 658 µM -0.334377557992299 0.336337281126046 no 2246 0.369047335956603 2986 723597 SGTC_1494 4358-1428 177 µM -0.334711978888699 0.336220852889072 no 2247 0.368921182165105 3136 1564571 SGTC_1209 2323-2347 50.3 µM -0.339251438362775 0.334642003186886 no 2248 0.367210161083416 3103 5412760 SGTC_2455 5377712 9.75 µM -0.339429454759907 0.334580147385562 no 2249 0.367143116276148 3063 2243908 SGTC_1861 st057647 17.4 µM -0.339828071466273 0.33444165532893 no 2250 0.366993003337955 3186 688668 SGTC_2026 5148700 152 µM -0.340334987992046 0.334265569029659 no 2251 0.36680213572144 2978 79838 SGTC_1574 spiramycin 23.7 µM -0.340394220634136 0.334244995916723 no 2252 0.366779835196651 2950 6419898 An antibiotic and protein synthesis inhibitor. SGTC_856 0433-0016 11.3 µM -0.341352124815701 0.33391235883077 no 2253 0.366419255888721 3096 3911780 SGTC_2183 6420625 130.508 µM -0.342449820392654 0.333531338882234 no 2254 0.3660062005334 3026 2897619 SGTC_1503 4585-0012 61.3 µM -0.342723255125809 0.33343645393186 no 2255 0.365903333043528 3178 2922052 SGTC_623 k072-0108 16.9 µM -0.342971833417655 0.33335020369493 no 2256 0.365809825033735 3070 5382803 SGTC_577 r071-0003 38.6 µM -0.3431614758079 0.333284408615833 no 2257 0.365738492376893 3008 4568517 YMR134W ERG29 SGTC_46 0329-0187a 2.197 µM -0.343850811212195 0.333045291822476 no 2258 0.365479242812909 3097 46494817 SGTC_457 grayanotoxin iii 135 µM -0.345692075807243 0.3324069265605 no 2259 0.364787070063285 3094 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity. SGTC_2704 st078022 71.1 µM -0.345709336054043 0.332400944739595 no 2260 0.364780583629005 3173 54697681 SGTC_2692 st077426 47.7 µM -0.346020963152964 0.332292952614355 no 2261 0.36466348021912 3187 25238571 SGTC_1795 st049545 62.3 µM -0.347327989173809 0.33184016391228 no 2262 0.364172462885324 3140 5291882 SGTC_1136 pergolide 1.05886 µM -0.348144936820577 0.33155727607862 no 2263 0.363865669002251 2996 47811 A dopamine receptor agonist. SGTC_390 dec-rvkr-cmk 16.7 µM -0.349408547847638 0.331119909494758 no 2264 0.363391308495227 3084 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1 SGTC_3227 9130768 49.47 µM -0.350618176277125 0.330701443348725 no 2265 0.362937409250794 3031 17720899 SGTC_59 0330-0160 1.33 µM -0.350940862744173 0.330589846964561 no 2266 0.362816357337524 3060 4293482 SGTC_518 1021-0119 62.6 µM -0.351311960488886 0.330461526867765 no 2267 0.362677161468064 3054 1097762 SGTC_103 0844-0104 51.839 µM -0.353734620617698 0.329624297260155 no 2268 0.36176888722785 3139 5375804 SGTC_1959 st077091 55.8 µM -0.354238968284774 0.329450110547007 no 2269 0.361579901031334 2978 821356 YKL052C ASK1 SGTC_349 k015-0014 24 µM -0.354296412295965 0.329430273437222 no 2270 0.361558378089603 2964 2196908 SGTC_2218 6965428 192.983 µM -0.355251461256849 0.329100537260724 no 2271 0.361200607572361 3101 675684 SGTC_3033 9090887 49.47 µM -0.355534723834497 0.329002764764176 no 2272 0.361094518012425 3034 19325384 SGTC_1923 st058458 19.1 µM -0.35653192584986 0.328658658051441 no 2273 0.360721123722422 3238 3534982 SGTC_2878 9043973 25.97 µM -0.35792161509891 0.328179357162771 no 2274 0.360200987182896 3161 6465167 SGTC_257 daunorubicin 18.5 µM -0.35872688537231 0.32790175047695 no 2275 0.359899706818767 3129 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_3035 9091303 49.47 µM -0.359655844444525 0.327581621741809 no 2276 0.359552258163568 3074 25237002 SGTC_1724 st037281 8.293 µM -0.360471413573029 0.327300672777758 no 2277 0.359247315210217 3005 574124 YDL195W SEC31 SGTC_2203 7227154 166.4 µM -0.363420864461198 0.326285457110367 no 2278 0.358145259061084 3088 896304 SGTC_1993 st073995 70.8 µM -0.363850614638305 0.326137642105442 no 2279 0.357984782155631 3047 3098394 SGTC_890 0929-0006 47.2 µM -0.364178830710745 0.326024768723376 no 2280 0.357862236917501 3045 1378169 SGTC_444 curcumin 90.4 µM -0.366156882214668 0.325344855365881 no 2281 0.357124007164901 3170 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. SGTC_1564 D-Arginine 115 µM -0.36636098330625 0.32527473295935 no 2282 0.357047864855578 3093 71070 D-isomer of arginine; arginine decarboxylase inhibitor. SGTC_1756 st041558 35.5 µM -0.366532471357675 0.325215820100622 no 2283 0.356983893625201 3235 3955792 SGTC_1058 3448-5425 97.3 µM -0.366921801597043 0.325082086141538 no 2284 0.35683867432822 3062 7279705 SGTC_3141 9094609 49.47 µM -0.367982870030671 0.324717726220601 no 2285 0.35644300356779 3003 25236309 YDL196W YDL196W SGTC_2597 laccaic acid a 100 µM -0.370789043768991 0.323754923945186 no 2286 0.355397331205547 3169 5491415 A textile dye. SGTC_2897 9048598 12.99 µM -0.371305544545664 0.323577839986791 no 2287 0.355204984365247 3064 6467404 SGTC_3174 9107204 49.47 µM -0.371997428603287 0.323340687900853 no 2288 0.354947381934411 3188 3938802 SGTC_38 0929-0051 58.268 µM -0.372157527536376 0.323285822169557 no 2289 0.35488778330383 3175 1379719 SGTC_2720 fluspirilene 36.88 µM -0.37264127334601 0.323120066357121 no 2290 0.354707725058498 3139 3396 An atypical antipsychotic. SGTC_1584 6-fluoro-dl-tryptophan 90 µM -0.373464885907418 0.322837935785705 no 2291 0.354401237436604 3253 94937 An inhibitor of serotonin biosynthesis. SGTC_2764 methyldopa 94.69 µM -0.373987332946241 0.322659023053332 no 2292 0.354206870174666 3238 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent. SGTC_2912 7964298 10.93 µM -0.37433719076785 0.322539236689741 no 2293 0.354076732931364 3145 2975850 SGTC_1616 st002734 56.1 µM -0.375194327870583 0.322245842942269 no 2294 0.353757974152075 3056 4026101 SGTC_3108 9121785 49.47 µM -0.3756151382206 0.322101842169233 no 2295 0.353601517441679 3078 17140271 SGTC_2800 7887935 81.82 µM -0.376323061915728 0.321859651823151 no 2296 0.353338368187023 3203 2961002 SGTC_449 xestospongin c 11.1929 µM -0.376589314737467 0.321768582676542 no 2297 0.353239414874478 3163 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1 SGTC_2588 indole-3-carbinol 100 µM -0.377085436795067 0.321598917594059 no 2298 0.353055056742666 3189 3712 Induces cell cycle arrest. SGTC_474 dl-dihydrosphingosine 5 µM -0.380025115362622 0.32059436314971 no 2299 0.351963385956051 3222 3058739 A sphingolipid protein kinase C inhibitor. SGTC_742 0kpi-0133 140 µM -0.380686361416292 0.320368581045405 no 2300 0.351717995111695 3220 2728852 SGTC_2798 7813637 45.45 µM -0.382554747384726 0.319730981165563 no 2301 0.351024964315319 3203 956368 SGTC_2344 7990960 76.95 µM -0.383152605036235 0.319527070364246 no 2302 0.350803308528215 3086 140813 SGTC_304 1310-0298 97 µM -0.383855806750605 0.31928729977471 no 2303 0.350542661399425 3133 1550234 SGTC_1318 1280-3875 124 µM -0.384400033145371 0.319101786837533 no 2304 0.350340987979917 3135 373245 SGTC_1528 arabinosylhypoxanthine 74.6 µM -0.384489470367546 0.31907130429539 no 2305 0.350307849354473 3296 804 An inhibitor of viral and cellular DNA polymerases. SGTC_3311 9131146 2.8755 µM -0.385444939243972 0.318745731921481 no 2306 0.349953896491056 3114 4900406 YPR165W RHO1 SGTC_1689 st020265 53.493 µM -0.385669477187987 0.318669241758651 no 2307 0.34987073544904 3224 5758320 YPR016C TIF6 SGTC_3094 9117742 49.47 µM -0.385779356215671 0.318631813640842 no 2308 0.349830042704251 3033 17149698 SGTC_1557 sumaresinolic acid 42.3 µM -0.385903554150259 0.318589510298329 no 2309 0.349784049153223 3076 9982268 A natural terpine and antifungal of unknown mechanisn. SGTC_1822 st052468 42 µM -0.386352654712348 0.31843656086565 no 2310 0.349617754566431 3143 2873678 SGTC_1482 3346-2049 8.48 µM -0.38638906091162 0.318424163422198 no 2311 0.349604275210608 3170 3826804 SGTC_2048 5246248 200 µM -0.387202496733081 0.318147216264246 no 2312 0.34930315095534 3216 677046 SGTC_2452 5863136 48.41 µM -0.390263161064551 0.317106076145601 no 2313 0.348170980527005 3048 2184096 SGTC_3261 9137475 49.47 µM -0.390312710352348 0.317089232936273 no 2314 0.348152662841438 3120 17027690 SGTC_2167 5876490 200 µM -0.391185405077289 0.316792641367348 no 2315 0.34783009778655 3262 686534 SGTC_1141 3253-0389 52.6 µM -0.392821197649305 0.316237022739933 no 2316 0.347225773593319 3182 5402031 SGTC_907 3448-6986 75.5 µM -0.392972513633195 0.316185647194721 no 2317 0.347169891289847 3278 590582 SGTC_2583 asiatic acid 100 µM -0.39313046585812 0.316132022265828 no 2318 0.347111561709718 3266 5320556 A kinase inhibitor; arrests cells at G2/M. SGTC_10 0279-0212 42.575 µM -0.397295969706543 0.314719228563315 no 2319 0.345574609526974 3126 39851 YBR002C RER2 SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM -0.39991317915915 0.313832945985129 no 2320 0.344610232468077 3076 279621 SGTC_2872 9044037 25.97 µM -0.403730515835716 0.312542181320136 no 2321 0.343205448497359 3100 6465195 SGTC_1164 k060-0068 93.7 µM -0.403809916018681 0.312515357881043 no 2322 0.343176252052643 3113 5963676 SGTC_2176 5809774 33.9695 µM -0.404456133334472 0.312297085874903 no 2323 0.34293866465383 3216 2870539 SGTC_556 4058-0063 51.5 µM -0.404802437592628 0.312180142220122 no 2324 0.34281136843774 3163 6615692 SGTC_2571 chrysanthemic acid 100 µM -0.405545252682794 0.311929364461706 no 2325 0.342538381029705 3143 2743 An insecticide. SGTC_684 1140-0066 328 µM -0.405997316534397 0.31177678829878 no 2326 0.342372286060828 3189 6813534 SGTC_2558 carylophyllene oxide 100 µM -0.407714001124449 0.311197684137319 no 2327 0.341741828560703 3168 6708694 An oxygenated terpenoid and antifungal agent. SGTC_748 act1.228 77.9 µM -0.407718669956632 0.311196109795694 no 2328 0.341740114519028 3111 4421505 YNR035C ARC35 SGTC_2466 5983409 37.09 µM -0.408062221382813 0.311080272894663 no 2329 0.341613997402987 3151 2879657 SGTC_2489 cantharidin 73.42 µM -0.408902849516102 0.310796913155199 no 2330 0.341305478893002 3147 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_2630 antimycin a 100 µM -0.40901247177024 0.310759969844775 no 2331 0.341265254295571 3075 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain. SGTC_1886 st057356 49.9 µM -0.409543558084275 0.310581017813471 no 2332 0.341070403957218 3114 24207747 SGTC_3117 9124945 49.47 µM -0.410196781598664 0.31036097253758 no 2333 0.340830800802406 3067 17592065 SGTC_2160 5660466 132.927 µM -0.412016606836733 0.309748303147167 no 2334 0.34016362555741 3221 2859134 SGTC_1389 3405-0187 19 µM -0.412096196527566 0.309721520216861 no 2335 0.340134458182128 3163 799890 SGTC_956 1185-0240 191 µM -0.412693808814486 0.309520448455629 no 2336 0.339915480716164 3123 1416193 SGTC_1523 st012844 44.7 µM -0.41290047231734 0.309450928015929 no 2337 0.33983976750947 3262 4274103 SGTC_985 1493-0307 8.71 µM -0.413565135698854 0.309227385235069 no 2338 0.339596305357839 3282 3278274 SGTC_118 0083-0097 135.343 µM -0.413995872504258 0.309082555460642 no 2339 0.339438564814757 3174 5207356 SGTC_20 0481-0013 4.944 µM -0.414387148884513 0.308951019467796 no 2340 0.339295299490871 3184 182045 SGTC_658 3253-0951 102 µM -0.414754374614955 0.308827590902183 no 2341 0.339160861409405 3169 1184878 SGTC_859 0439-0102 54.6 µM -0.415049780592223 0.30872831740451 no 2342 0.339052730761249 3262 610143 SGTC_2047 4141938 200 µM -0.415327546505442 0.308634984737232 no 2343 0.338951069189661 3161 3807862 SGTC_2010 4012422 159 µM -0.416268197436701 0.308319006619299 no 2344 0.338606880639962 3175 952393 SGTC_2284 7945075 39.21 µM -0.416573196250668 0.308216583616081 no 2345 0.338495309071658 3258 1245402 SGTC_41 0478-0632 82.643 µM -0.416768306314354 0.308151070671055 no 2346 0.338423943323506 3249 3750424 SGTC_364 0083-0097 67.7 µM -0.417551425387847 0.307888180923386 no 2347 0.338137558905642 3259 5207356 SGTC_1773 st048542 73.5835 µM -0.418515011839584 0.307564844310938 no 2348 0.337785306577702 3132 3237138 SGTC_2191 5911152 200 µM -0.41856386813157 0.307548454298325 no 2349 0.337767450266622 3192 2875902 SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM -0.419562287750072 0.307213594724367 no 2350 0.337402621486388 3136 6312947 SGTC_2763 lisinopril 49.32 µM -0.419651696513005 0.307183615788576 no 2351 0.337369958414185 3217 5362119 A lysine-analog of enalapril and an ACE inhibitor. SGTC_1710 st031758 61.5 µM -0.419707146327927 0.307165024002909 no 2352 0.337349701940424 3297 5394341 SGTC_1726 st035556 14.5795 µM -0.420414889351337 0.306927768177701 no 2353 0.337091196462021 3313 5919439 SGTC_337 1315-0038 354 µM -0.420985098450662 0.306736676474482 no 2354 0.336882981639421 3173 1626437 SGTC_1963 st076565 50.3 µM -0.421741686514178 0.306483205466787 no 2355 0.336606786724896 3133 4914280 SGTC_143 4032-1194 15.74 µM -0.421895725194109 0.306431610993518 no 2356 0.336550565199657 3081 1806963 SGTC_2150 5556613 200 µM -0.423974824669756 0.305735602932153 no 2357 0.335792086792882 3158 743190 SGTC_1168 k815-0004 80.5 µM -0.424019779159826 0.305720561514247 no 2358 0.335775694270853 3090 642433 SGTC_1540 guanosine 70.6 µM -0.424026940902782 0.305718165281793 no 2359 0.335773082791291 3196 6802 Guanosine is a purine nucleoside SGTC_2673 kobusone 100 µM -0.424270054589128 0.305636827321748 no 2360 0.335684437787715 3184 6710676 An epoxy ketone and protein crosslinker. SGTC_2155 5570423 76 µM -0.424641751168173 0.305512488233204 no 2361 0.335548926095087 3135 797402 SGTC_3343 9148379 18.9835 µM -0.425343557047358 0.305277782897046 no 2362 0.335293122763726 3294 1955036 SGTC_1925 st057770 10.1 µM -0.425516476720227 0.305219965559312 no 2363 0.335230106472482 3139 5989122 SGTC_546 peri-Naphthalide 147 µM -0.427848171957684 0.304440816136759 no 2364 0.334380831314569 3164 223824 A penicillin ester. SGTC_1976 st070609 63.5 µM -0.428351355464891 0.304272790662 no 2365 0.334197667359081 3132 682556 SGTC_2114 5491910 81.25 µM -0.42847968683063 0.30422994424126 no 2366 0.334150959742354 3259 2849228 SGTC_2778 tioconazole 65.09 nM -0.430431549577472 0.30357860090856 no 2367 0.333440874712152 3202 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_1357 1503-1303 39.5 µM -0.431282412375193 0.303294860071276 no 2368 0.333131518481153 3167 292895 SGTC_2207 7258803 200 µM -0.431514607607409 0.303217449532777 no 2369 0.333047116771013 3240 3666799 SGTC_1252 0493-0875 34.8 µM -0.432331752229762 0.302945095589049 no 2370 0.332750156392855 3139 3960963 SGTC_2998 9066762 71.4286 µM -0.432444358328379 0.30290757261116 no 2371 0.33270924217501 3342 4945196 SGTC_527 4476-4215 268 µM -0.433950999012782 0.302405725078339 no 2372 0.332162012270591 3154 4418754 SGTC_1350 1495-0454 146 µM -0.436174807592613 0.301665678019796 no 2373 0.331354952269521 3308 1069057 SGTC_2289 7946404 165.07 µM -0.441632270768188 0.299852985214671 no 2374 0.32937766395396 3151 1246120 YPR165W RHO1 SGTC_147 4466-0538 29.23 µM -0.443200690702822 0.299332949228518 no 2375 0.328810289672892 3371 6742687 YHR072W ERG7 SGTC_2652 actinonin 100 µM -0.444240679037264 0.298988349337564 no 2376 0.328434292290102 3157 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase. SGTC_821 1114-0266 29.2 µM -0.444519620922983 0.298895952660125 no 2377 0.328333473165024 3259 3123235 SGTC_931 2812-0076 566 µM -0.445300783354987 0.29863726956321 no 2378 0.328051200920837 3166 3450959 SGTC_401 neomycin 50 µM -0.447414930569653 0.297937677714793 no 2379 0.327287748770367 3214 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis. SGTC_2112 5488546 200 µM -0.448247775215308 0.297662286612719 no 2380 0.326987193366776 3175 600757 SGTC_1899 st063254 59.6 µM -0.448258950797246 0.297658592048597 no 2381 0.326983161106254 3139 3093813 SGTC_2745 rifampicin 24.3 µM -0.448356921217768 0.297626204653383 no 2382 0.326947813274094 3212 25141428 Inhibits bacterial DNA-dependent RNA polymerase. SGTC_468 gf-109203x 121 µM -0.448476629885254 0.2975866331378 no 2383 0.326904624366914 3217 2396 A protein kinase C inhibitor. SGTC_899 1083-0020 478 µM -0.448577451718692 0.297553306814861 no 2384 0.326868251315778 3341 767123 SGTC_2985 9022375 71.43 µM -0.449190999944277 0.297350537224236 no 2385 0.326646939685829 3353 4939335 SGTC_1961 st076550 68.7 µM -0.450277670848341 0.296991561832669 no 2386 0.32625511871576 3287 1579337 SGTC_2118 5526350 200 µM -0.450563521070854 0.296897165822195 no 2387 0.326152081516222 3286 743594 SGTC_3326 9140064 16.379 µM -0.450833322691567 0.296808082120655 no 2388 0.326054841347799 3155 1868434 SGTC_54 0159-0055 9 µM -0.451751346830689 0.29650505854212 no 2389 0.325724061600214 3404 3319099 SGTC_2920 7982904 15.77 µM -0.4525490738314 0.296241858100396 no 2390 0.325436738325699 3258 6456808 SGTC_3110 9122132 49.47 µM -0.455224014836508 0.295360076565819 no 2391 0.324474042657212 3376 918317 SGTC_308 4092-1169 104 µM -0.456059035649386 0.295085063477345 no 2392 0.324173763221303 3200 2268590 YDL196W YDL196W SGTC_1632 st005650 90 µM -0.457462085284214 0.294623236543939 no 2393 0.323669474101397 3275 2759605 SGTC_326 k292-0812 17.5 µM -0.459354213209589 0.29400095349489 no 2394 0.322989911271317 3286 3579357 SGTC_2680 butyl paraben 22.24 µM -0.459640324455498 0.293906910140267 no 2395 0.322887204987525 3277 7184 An antifungal and steroid mimetic. SGTC_3078 9116413 49.47 µM -0.459976739372526 0.293796350017201 no 2396 0.322766458308372 3164 17177322 SGTC_634 1611-4317 11.2 µM -0.460789267314109 0.293529398477071 no 2397 0.322474901318138 3342 2843522 SGTC_617 3770-0098 35 µM -0.46115374498511 0.293409687869812 no 2398 0.322344152326862 3230 5962639 SGTC_398 bronopol 33.3 µM -0.462893479819581 0.292838593807603 no 2399 0.321720360660254 3165 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them. SGTC_2504 purpurogallin 52.29 µM -0.463215897898032 0.292732811939781 no 2400 0.321604810962082 3190 5281571 An antioxidant. SGTC_397 arbidol 50 µM -0.464605505090407 0.292277100105032 no 2401 0.321106994616545 3346 131410 A RNA synthesis inhibitor. SGTC_1302 1159-0335 255 µM -0.465088150046581 0.292118897355542 no 2402 0.320934165822343 3222 649284 SGTC_1043 0916-0009 19.3 µM -0.465537346660744 0.291971694214799 no 2403 0.320773349289335 3383 3101130 SGTC_2947 9072639 7.68 µM -0.466681900935983 0.291596776396555 no 2404 0.320363740351529 3308 16488146 SGTC_3060 1327-0027 12.5 µM -0.467345497510806 0.291379507131673 no 2405 0.320126354958435 3249 16000455 YPR107C YTH1 SGTC_2283 7944793 200 µM -0.467972259102708 0.291174367459685 no 2406 0.319902213968569 3284 2970533 SGTC_32 0928-0142 34.1 µM -0.469356681813919 0.290721483724575 no 2407 0.319407353061004 3300 2244242 SGTC_428 3448-4153 16.5 µM -0.470595532025701 0.290316500360815 no 2408 0.318964799443633 3145 3834874 SGTC_2712 st079126 47.7 µM -0.472253455502637 0.289774934608061 no 2409 0.31837294423092 3209 3152970 SGTC_2593 nobiletin 86.24 µM -0.472564386512999 0.289673420854265 no 2410 0.318261997806126 3268 72344 An anti-infammatory. SGTC_2156 5649887 115 µM -0.472598216307072 0.289662377001455 no 2411 0.318249927639751 3329 54680440 YKL052C | YBR257W ASK1 | POP4 SGTC_1610 st001799 48.1 µM -0.47549619015715 0.28871705789037 no 2412 0.31721667405843 3164 621897 SGTC_2490 carminic acid 95.39 µM -0.476773048454757 0.28830100825553 no 2413 0.316761869760848 3331 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_2023 5144124 124 µM -0.47697283571307 0.28823593545644 no 2414 0.316690732543113 3210 2830192 SGTC_3040 9091894 49.47 µM -0.477884008628537 0.287939244792313 no 2415 0.316366381894755 3223 25236966 SGTC_1544 7-methoxy-4-methylcoumarin 105 µM -0.478664229202919 0.287685308697343 no 2416 0.316088758625469 3240 390807 SGTC_927 2425-1185 123 µM -0.481133506312152 0.286882338593237 no 2417 0.315210807849654 3187 730375 SGTC_1222 0366-0074 1.18 µM -0.481370255660288 0.286805407252208 no 2418 0.315126686385418 3370 286520 SGTC_903 1134-0042 114 µM -0.483370899354344 0.286155691888414 no 2419 0.314416203466303 3265 701009 SGTC_313 3474-0040 5.03 µM -0.484422133340879 0.285814580755432 no 2420 0.3140431568119 3216 1043375 YIL048W NEO1 SGTC_1010 4112-3296 15.2 µM -0.484853767664781 0.285674577308269 no 2421 0.313890039672315 3394 704384 SGTC_2025 5147754 141 µM -0.485326468536357 0.28552129109812 no 2422 0.313722391423067 3285 315777 YLR208W SEC13 SGTC_1434 4073-0095 163 µM -0.486508466616237 0.28513816728349 no 2423 0.313303351958425 3357 24133745 SGTC_2477 5967686 25.23 µM -0.487666834069207 0.284762940821749 no 2424 0.312892923695078 3215 776118 SGTC_1533 dihydroergotamine mesylate 29.4 µM -0.488505811445238 0.284491320650265 no 2425 0.312595805193057 3370 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release. SGTC_3312 9133330 71.43 µM -0.488733590325419 0.284417598266157 no 2426 0.312515159758594 3367 17617324 SGTC_1977 st070720 65.3 µM -0.489163520299983 0.284278473006724 no 2427 0.312362966909358 3356 682188 SGTC_2843 9000894 45.46 µM -0.491386922672643 0.283559500031091 no 2428 0.311576405879815 3275 2242070 SGTC_606 k015-0008 38.6 µM -0.491673386579278 0.283466930709626 no 2429 0.311475127489421 3380 1970475 SGTC_3088 9117578 49.47 µM -0.494526209215644 0.282545847188367 no 2430 0.310467300610616 3384 678341 SGTC_170 4197-0004 226 µM -0.49637125550988 0.281950909072054 no 2431 0.3098162507146 3383 218692 SGTC_2035 5154463 94.595 µM -0.496786106089058 0.281817222985127 no 2432 0.309669947003583 3392 2769623 SGTC_2033 5192550 145 µM -0.497270866151013 0.28166104719896 no 2433 0.309499026791378 3279 182073 SGTC_2699 st077704 54.6 µM -0.497964683695072 0.281437591723325 no 2434 0.309254467263308 3335 645852 SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM -0.498020088488621 0.281419751377251 no 2435 0.309234941605718 3570 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W SGTC_2093 5331342 194.4 µM -0.499784974220685 0.280851743843122 no 2436 0.308613245916337 3389 33839 SGTC_1794 st048918 76.9 µM -0.499904222406279 0.280813385228156 no 2437 0.308571259503183 3332 672303 SGTC_3096 9117468 49.47 µM -0.502406863896545 0.280008944453425 no 2438 0.307690675892764 3336 41316311 SGTC_508 roscovitine 141 µM -0.503911674344224 0.279525781608807 no 2439 0.307161723204257 3348 160355 A CDKinase inhibitor. SGTC_1358 1509-0022 2.48 µM -0.505001045157643 0.279176260440225 no 2440 0.306779050948536 3353 3258434 SGTC_3299 9121982 43.1275 µM -0.505400163321845 0.279048257841066 no 2441 0.306638902086142 3297 17594604 YPL160W CDC60 SGTC_3274 9138298 49.47 µM -0.505656247982965 0.278966143056891 no 2442 0.306548993793632 3341 17015756 SGTC_335 4077-0256 27.6 µM -0.506256870146473 0.278773596783036 no 2443 0.306338168142716 3337 3121989 SGTC_1081 sertraline 6 µM -0.506696632583278 0.278632659636285 no 2444 0.306183846845323 3404 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1 SGTC_3288 9119690 36.221 µM -0.508553090464553 0.278038075925314 no 2445 0.305532758430809 3303 17595618 YKL019W RAM2 SGTC_2970 9090938 41.86 µM -0.5094488015558 0.277751420399475 no 2446 0.305218838367302 3433 17217104 SGTC_3269 9137823 49.47 µM -0.509565420102328 0.277714109443362 no 2447 0.30517797757251 3256 17682936 SGTC_296 1222-0039 74.9 µM -0.509602992734495 0.277702088970926 no 2448 0.305164813394513 3324 5984176 SGTC_2422 chlorphenesin carbamate 384.24 µM -0.509983242412151 0.277580451407835 no 2449 0.305031600969531 3268 2724 A muscle relaxant with antifungal properties. SGTC_52 0329-0193 875 nM -0.510046049830204 0.277560362531871 no 2450 0.305009600205413 3467 3739292 SGTC_2 0422-0095 29 µM -0.51067470791042 0.277359326164247 no 2451 0.304789426872571 3300 6790840 SGTC_300 r073-0011 5.04 µM -0.511229041304007 0.277182116917153 no 2452 0.304595342718772 3409 2735780 SGTC_1939 st074455 53.6 µM -0.511295159204157 0.277160984051094 no 2453 0.304572197076747 3467 1644229 SGTC_2177 5811945 192 µM -0.511303639014013 0.277158273757597 no 2454 0.304569228638547 3406 5343475 SGTC_1684 st024538 14.6195 µM -0.511318868351915 0.277153406231074 no 2455 0.304563897496087 3309 6732859 SGTC_2781 5567276 71.43 µM -0.512755137095724 0.276694541110638 no 2456 0.30406130769284 3411 2853274 SGTC_2832 7992762 51.95 µM -0.514182097873153 0.2762390186982 no 2457 0.303562341409598 3173 2985177 SGTC_1230 0170-0365 3.77 µM -0.516067665314733 0.275637662272173 no 2458 0.302903575256264 3465 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1 SGTC_1017 4239-0030 168 µM -0.516331105114575 0.275553695750741 no 2459 0.302811587504029 3307 1149593 SGTC_3032 9089427 49.47 µM -0.516362316812306 0.2755437484379 no 2460 0.302800689850913 3373 17173707 SGTC_1953 st076800 12.1 µM -0.518545850044017 0.274848284944433 no 2461 0.302038739384109 3316 297591 SGTC_1468 k284-1086 134 µM -0.521704612857804 0.273843740752374 no 2462 0.300938006218864 3364 15996457 SGTC_2257 7960413 200 µM -0.521887526185153 0.273785626630237 no 2463 0.300874321902821 3328 2974689 YIL048W NEO1 SGTC_2324 6149169 200 µM -0.52221627024723 0.273681195378071 no 2464 0.300759879473883 3308 2888231 SGTC_1841 st054148 70 µM -0.522483568257634 0.273596298057587 no 2465 0.300666842133192 3357 675442 SGTC_1013 4112-3890 241 µM -0.522945402522927 0.273449644212124 no 2466 0.30050612396269 3242 705171 SGTC_2787 5284540 71.43 µM -0.5237590356762 0.273191372580191 no 2467 0.300223074328834 3326 736958 SGTC_2555 cholic acid 100 µM -0.524687837993219 0.272896690604008 no 2468 0.299900106647676 3455 6708657 Influences liver metabolism. SGTC_1120 ficusin 1.78878 µM -0.524793881179396 0.272863056212543 no 2469 0.29986324279718 3406 6199 A DNA cross-linker. SGTC_84 0443-0269 128.823 µM -0.526430224886982 0.272344307475321 no 2470 0.299294659993093 3393 6150058 SGTC_1808 st050063 61.5 µM -0.52716943918045 0.272110124755058 no 2471 0.299037964565522 3422 4011993 SGTC_2430 5571206 200 µM -0.527320354342881 0.27206232721495 no 2472 0.298985570898994 3456 1731771 SGTC_1767 st044992 70.3 µM -0.527978216684409 0.271854019181031 no 2473 0.298757227582258 3363 9600693 SGTC_724 3910-0327 137 µM -0.528223220008941 0.271776460681715 no 2474 0.298672207451525 3408 2885483 SGTC_1139 k015-0024 46.9 µM -0.528827971399189 0.271585067121038 no 2475 0.298462396005456 3408 2766652 SGTC_2888 9058547 12.99 µM -0.529733809886075 0.271298510216925 no 2476 0.298148251423762 3328 16476514 SGTC_983 1491-0821 12.2 µM -0.529953347082276 0.271229083554927 no 2477 0.298072138655501 3409 46495113 SGTC_1244 0416-0015 52.5 µM -0.530098986614599 0.271183031251132 no 2478 0.298021650830935 3326 96201 SGTC_993 3909-8757 62.7 µM -0.53042057435827 0.271081356624132 no 2479 0.297910182093215 3306 4288324 YLR208W SEC13 SGTC_663 1486-0733 13.9 µM -0.531560242186999 0.270721187267451 no 2480 0.297515303585684 3337 722445 YPR165W RHO1 SGTC_937 3122-0005 46.7 µM -0.531562983433173 0.270720321239232 no 2481 0.297514354071473 3423 759535 SGTC_2248 tofa 1.1 µM -0.531805150980175 0.270643819914248 no 2482 0.297430477416966 3281 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_3056 9094900 49.47 µM -0.535470722559768 0.269487176996524 no 2483 0.296162198723069 3339 25236784 SGTC_1754 st042065 16.137 µM -0.535626185316805 0.269438176740088 no 2484 0.296108463882507 3402 1126236 YIL048W NEO1 SGTC_761 k216-0224 480 µM -0.537758363151618 0.26876658730043 no 2485 0.295371940320444 3505 1340404 SGTC_1914 st062367 72.6 µM -0.539113924545434 0.268340052739953 no 2486 0.294904124050982 3335 978205 SGTC_2619 obliquin 87.91 µM -0.54309212417373 0.267090260131008 no 2487 0.293533187498521 3420 6708593 A bioactive alkalod. YER133W GLC7 SGTC_805 3852-0218 479 µM -0.544397422569567 0.266680828414165 no 2488 0.29308400952941 3329 6615355 SGTC_71 0417-1750 47.813 µM -0.544876505213191 0.26653063464887 no 2489 0.292919228109963 3453 6811472 SGTC_2135 5326629 150.42 µM -0.545838471864775 0.266229184627044 no 2490 0.292588487693005 3350 5020077 SGTC_2394 5221648 200 µM -0.549019356889681 0.265233625961098 no 2491 0.291496082973198 3445 788586 SGTC_2596 sinensetin 100 µM -0.549570569022674 0.265061299031632 no 2492 0.291306974891734 3343 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets. SGTC_2098 5376439 882.5 nM -0.551448150772164 0.264474732752296 no 2493 0.290663250281287 3427 2844116 SGTC_192 3455-0609 60.9 µM -0.551610562663123 0.264424025493246 no 2494 0.290607599017022 3480 3769639 SGTC_1 0258-0098 57.368 µM -0.552205098493955 0.264238445329781 no 2495 0.290403920813499 3367 6790032 YDR047W HEM12 SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM -0.552306071377421 0.264206933947085 no 2496 0.290369335803499 3367 115019 SGTC_3000 9075062 71.4286 µM -0.553587297940962 0.263807258024272 no 2497 0.289930660482334 3358 17057871 SGTC_1996 st072960 66.8 µM -0.553773780477916 0.263749110902568 no 2498 0.289866837203544 3483 1719405 SGTC_3125 9127534 49.47 µM -0.554201350564792 0.263615814948255 no 2499 0.289720527070022 3381 1639235 SGTC_1788 fluconazole 20 µM -0.554570473128067 0.263500767793681 no 2500 0.28959424496514 3433 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11 SGTC_1809 st050081 57.6 µM -0.554752378434641 0.263444081451026 no 2501 0.289532022066624 3526 5036894 SGTC_3037 9091026 49.47 µM -0.555863404544885 0.263097992490822 no 2502 0.289152118558312 3476 25236398 YIL048W NEO1 SGTC_1499 4480-0877 67.3 µM -0.557673769252803 0.262534554966921 no 2503 0.288533586302012 3420 2861909 SGTC_3057 9095946 49.47 µM -0.557793046584082 0.262497454131604 no 2504 0.288492855708808 3448 24540043 SGTC_3320 9137005 35.139 µM -0.558075984370748 0.262409457966564 no 2505 0.28839624949724 3403 4908713 SGTC_2885 9057732 51.95 µM -0.559503054994065 0.261965856656743 no 2506 0.287909223428059 3492 6471414 SGTC_1398 3558-0053 112 µM -0.560837257955775 0.261551471068316 no 2507 0.287454242512653 3349 4532369 SGTC_2851 9015922 71.43 µM -0.561118433919967 0.26146418452412 no 2508 0.28735840117675 3478 2996893 SGTC_2197 6588183 93.1375 µM -0.562610548459186 0.26100123204713 no 2509 0.286850053764197 3425 884136 SGTC_2833 9001315 45.46 µM -0.563461654514815 0.260737351632791 no 2510 0.286560282065835 3324 2989378 SGTC_1475 4092-1048 11.7 µM -0.563881633142766 0.260607190338642 no 2511 0.286417345287222 3466 2881759 SGTC_216 k038-0035 28.382 µM -0.564448573132503 0.260431535315563 no 2512 0.286224444927294 3430 4444231 YPR107C YTH1 SGTC_236 1509-0011 5.31 µM -0.566633797287667 0.259755058219636 no 2513 0.285481503948047 3539 3107280 SGTC_3067 9117431 49.47 µM -0.566708301109872 0.25973201016065 no 2514 0.285456190042871 3400 17150885 SGTC_1519 esterone 74 µM -0.569707545949093 0.258805058844791 no 2515 0.284438035590978 3382 698 A steroid. SGTC_1319 1306-0155 43.7 µM -0.569810827454283 0.258773169019074 no 2516 0.284403005514466 3457 3122360 SGTC_1079 idarubicin 2.36 µM -0.570219125562855 0.258647120325339 no 2517 0.284264542881485 3466 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_2447 5741742 33.78 µM -0.57088865822883 0.258440492823887 no 2518 0.284037559787707 3469 1776504 SGTC_2312 7706453 155.7 µM -0.57114126485636 0.258362556974568 no 2519 0.28395194432819 3420 976098 SGTC_1296 1068-0102 11.9 µM -0.57136360220007 0.258293970080538 no 2520 0.283876598196282 3443 767053 SGTC_784 4579-0127 173 µM -0.571393458082599 0.25828476082029 no 2521 0.283866481302841 3522 1948547 SGTC_2679 rapamycin 1 nM -0.57153621505805 0.258240728763699 no 2522 0.283818109398873 3474 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2 SGTC_1624 st003710 6.25 µM -0.571606979918156 0.258218903445604 no 2523 0.283794132832015 3483 24207033 SGTC_1451 4152-0210 104 µM -0.571967765461336 0.258107644733056 no 2524 0.283671906466328 3506 659563 SGTC_399 oxolinic acid 75 µM -0.572474880129169 0.257951303215605 no 2525 0.2835001495868 3390 4628 A DNA gyrase inhibitor. SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM -0.572659702145252 0.25789433551082 no 2526 0.283437563806462 3447 688788 SGTC_2486 5283202 22.39 µM -0.574897246023822 0.257205175432295 no 2527 0.28268039629013 3407 1377751 SGTC_3131 9127911 49.47 µM -0.578927769608218 0.255966200326509 no 2528 0.281318955853857 3558 45595681 SGTC_1652 st011932 78 µM -0.579551104595755 0.255774866773754 no 2529 0.281108687126178 3466 1551076 SGTC_3038 9091290 49.47 µM -0.581099141303694 0.25530001787901 no 2530 0.280586818676811 3521 25236843 SGTC_2786 7743617 45.45 µM -0.582997945683549 0.254718203490134 no 2531 0.279947341579281 3385 583674 SGTC_1218 1348-1416 30.7 µM -0.584826146886122 0.254158679419638 no 2532 0.279332310655492 3482 6787668 SGTC_155 k072-0202 43.6 µM -0.585962474930786 0.25381122941564 no 2533 0.278950366078713 3469 5857737 SGTC_1169 aniline yellow 25.8 µM -0.587279099416638 0.253408963021477 no 2534 0.278508137905396 3455 6051 A DNA damaging agent. SGTC_1719 st032227 49.2 µM -0.587303528837547 0.253401502303079 no 2535 0.278499935773532 3477 3125804 SGTC_731 3966-0296 387 µM -0.587849227300602 0.253234876686403 no 2536 0.278316749226491 3498 660956 SGTC_618 k072-0232 33.2 µM -0.588343279388693 0.253084070674493 no 2537 0.278150950624353 3460 5872756 YGL099W LSG1 SGTC_2648 atorvastatin 78.68 µM -0.588773431407956 0.252952808203887 no 2538 0.278006635442256 3518 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11 SGTC_3277 9138724 49.47 µM -0.592129707580818 0.251929859778221 no 2539 0.276881867533998 3412 15943418 SGTC_3208 9114115 49.47 µM -0.593253258931108 0.251587904666019 no 2540 0.276505837269162 3448 650895 SGTC_128 0906-2981 13.371 µM -0.593778681988067 0.251428075288224 no 2541 0.276330074599604 3503 6740226 SGTC_2743 auranofin 4.32 µM -0.594757439822692 0.251130488344715 no 2542 0.276002810192407 3445 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold. SGTC_1433 4060-0023 7.6 µM -0.595224172034367 0.250988646135444 no 2543 0.275846817353458 3514 3840627 SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM -0.59671931810608 0.250534549487266 no 2544 0.275347396350094 3518 16623 A steroid. SGTC_3317 9138495 8.753 µM -0.597141159814275 0.250406509074513 no 2545 0.275206569833858 3530 17020139 SGTC_2584 androsterone 48.74 µM -0.598067729952588 0.250125391681844 no 2546 0.27489737065753 3565 2754130 A steroid. SGTC_2669 eugenol 100 µM -0.598142695851918 0.250102654672911 no 2547 0.274872361804626 3484 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism. SGTC_1782 st039423 80.636 µM -0.600121986140733 0.249502736684906 no 2548 0.27421247045441 3430 2068169 SGTC_1958 st076513 41.9 µM -0.60022845857628 0.249470486839938 no 2549 0.274176994949769 3438 732122 YGL099W LSG1 SGTC_986 1493-0483 84 µM -0.600815481692064 0.249292720935733 no 2550 0.273981445685683 3487 40079 SGTC_2302 7771753 200 µM -0.600842732382656 0.249284470352241 no 2551 0.273972369604402 3484 2203047 SGTC_3176 9106582 49.47 µM -0.601720286947665 0.249018854273699 no 2552 0.273680171838025 3446 17018027 SGTC_621 3584-0052 32.1 µM -0.601931748928886 0.248954871999095 no 2553 0.273609784779944 3551 2273927 SGTC_1142 3253-1408 9.78 µM -0.602899871961562 0.248662057741394 no 2554 0.273287650583893 3523 256655 SGTC_1138 3761-0006 1.03 µM -0.603326289162475 0.248533143673871 no 2555 0.27314582372928 3517 12061087 SGTC_3240 9133527 49.47 µM -0.605761013603422 0.247797762558697 no 2556 0.272336730896887 3512 17617455 SGTC_2693 st077581 40.7 µM -0.606913692169547 0.247450014578291 no 2557 0.271954095473004 3532 25238761 SGTC_3216 9129716 49.47 µM -0.608308489922814 0.247029571382711 no 2558 0.271491445624757 3479 8056934 SGTC_2886 9058944 51.95 µM -0.609149526159835 0.246776237048872 no 2559 0.271212666251346 3379 4949929 SGTC_2612 dictamnine 15.46 µM -0.60990424849478 0.246549020389016 no 2560 0.270962619013346 3471 68085 A quinoline derivative and established mutagen. YOR116C RPO31 SGTC_699 0375-0592 111 µM -0.610075252883164 0.24649755339677 no 2561 0.270905979495468 3572 762578 SGTC_2576 guaiol 23.12 µM -0.611115800351762 0.246184505154802 no 2562 0.270561460146004 3510 227829 SGTC_2011 4012611 177 µM -0.612736438961345 0.245697361671064 no 2563 0.270025312187816 3520 2049887 SGTC_744 1594-0068 283 µM -0.614344548435686 0.245214496378228 no 2564 0.26949383516853 3547 668392 SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM -0.614720425528965 0.245101705784239 no 2565 0.269369684166291 3616 6710655 SGTC_2421 5690543 90.72 µM -0.615727609938306 0.244799614472289 no 2566 0.269037155806877 3553 3397993 SGTC_1078 idebenone 36.1 µM -0.617567170220033 0.244248381015411 no 2567 0.268430345506473 3538 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen. SGTC_632 0781-2353 4.65 µM -0.617688142174975 0.244212154626607 no 2568 0.268390464975991 3559 6811515 YHR007C ERG11 SGTC_2705 st078069 42.8 µM -0.61836357371558 0.244009942438187 no 2569 0.26816785187745 3500 1530061 SGTC_2262 9014885 67.46 µM -0.618906161859649 0.243847566644382 no 2570 0.267989089493651 3492 6457424 SGTC_3207 9114163 49.47 µM -0.619110287278481 0.243786494844825 no 2571 0.267921853382077 3617 849233 SGTC_2020 4017018 200 µM -0.619387176006115 0.243703666360335 no 2572 0.267830663614862 3539 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope. SGTC_1950 st077106 7.18 µM -0.619679947924614 0.243616103106976 no 2573 0.267734259930721 3500 13831864 SGTC_788 1182-0090 188 µM -0.621061097980005 0.243203253122503 no 2574 0.267279711971182 3614 5715185 SGTC_659 k018-0002 107 µM -0.621864366677881 0.242963316089 no 2575 0.267015528781727 3559 6797879 YHR007C ERG11 SGTC_196 k015-0023 18.111 µM -0.621916204828581 0.242947836389754 no 2576 0.266998484511654 3540 5211998 SGTC_2852 9023854 51.95 µM -0.623763897473405 0.242396434464879 no 2577 0.266391326279734 3603 19798528 SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM -0.624746978760003 0.242103332757011 no 2578 0.266068567308586 3591 23847180 SGTC_3114 9122766 49.47 µM -0.626635762772206 0.241540739151884 no 2579 0.26544901009465 3507 17176985 SGTC_900 1112-0045 141 µM -0.628803128598619 0.240896042823137 no 2580 0.264738975778679 3503 56211 YIL048W NEO1 SGTC_1781 st038725 66.3 µM -0.628825454926953 0.240889406593542 no 2581 0.264731666647706 3549 4270275 YIL048W NEO1 SGTC_1196 1588-0294 184 µM -0.631688022750995 0.240039367465291 no 2582 0.263795377989798 3547 6144269 SGTC_183 3914-0051 30.55 µM -0.631822396309548 0.239999505481921 no 2583 0.263751468616338 3558 1596232 SGTC_2102 5377816 72.7585 µM -0.633785317130522 0.239417615728895 no 2584 0.263110468353004 3596 1379702 SGTC_1589 2',5'-dimethoxyflavone 47.2 µM -0.636219999272428 0.238696948475088 no 2585 0.262316519834308 3552 688667 SGTC_1663 st014140 55.4 µM -0.636734148022408 0.238544912099558 no 2586 0.262149013268719 3635 4207120 SGTC_1279 0874-0590 65.2 µM -0.63753181747608 0.2383091421739 no 2587 0.26188924589206 3560 3523074 SGTC_676 falcarinol 140 µM -0.637565054104296 0.238299321079149 no 2588 0.261878424986207 3634 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer. SGTC_422 cantharidin 155 µM -0.638272728585755 0.238090262894012 no 2589 0.261648080624395 3564 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_888 0916-0002 6.97 µM -0.638745059985563 0.237950784712309 no 2590 0.261494397090292 3621 2802138 YIL048W NEO1 SGTC_2272 7805186 180 µM -0.63897700557922 0.237882308211159 no 2591 0.261418945399837 3564 2956062 YPR165W RHO1 SGTC_3017 9080681 49.47 µM -0.63917878452343 0.237822746496363 no 2592 0.261353315987754 3561 16451914 SGTC_1778 st046819 58.9 µM -0.640100376244332 0.237550812297956 no 2593 0.261053672211692 3588 671715 SGTC_2719 novobiocin 32.65 µM -0.644776862066815 0.23617355448602 no 2594 0.259535899138421 3594 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication. SGTC_2181 6316240 54.2555 µM -0.645654973593713 0.235915435840269 no 2595 0.259251413359215 3566 12779990 SGTC_274 sirtinol 40.1 µM -0.646071241967568 0.235793129159629 no 2596 0.259116609332837 3582 6836442 NAD-dependent acetyltransferase inhibitor. SGTC_1307 1187-1599 12.2 µM -0.646771026708869 0.235587599389441 no 2597 0.258890073283884 3542 1538471 SGTC_478 N-arachidonylglycine 10 µM -0.648226884935728 0.23516032445812 no 2598 0.258419107795169 3540 5283389 SGTC_702 1488-0190 94 µM -0.6484221090935 0.235103061336868 no 2599 0.258355987171034 3583 949357 SGTC_1585 2',4'-dihydroxychalcone 10.4 µM -0.649248481481616 0.234860755231577 no 2600 0.258088889784596 3623 5357218 A potent inhibitor of glutathione S-transferases. SGTC_1764 st044502 93.5 µM -0.653505708224381 0.233614655364026 no 2601 0.256715155315585 3607 8407 SGTC_1815 st051655 58.2 µM -0.653928621034799 0.23349106832147 no 2602 0.256578896731677 3576 5984156 SGTC_470 aa-861 153 µM -0.654696632823321 0.233266726383869 no 2603 0.256331546808144 3569 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor. SGTC_2616 abietic acid 100 µM -0.657166896690425 0.232545955808782 no 2604 0.2555368041716 3624 6708678 Abietic acid is an inhibitor of 5α-reductase. SGTC_3284 9108171 64.8615 µM -0.660286249503899 0.231637566630249 no 2605 0.254535076243487 3568 8687505 SGTC_1413 3910-0535 34.4 µM -0.663101056162774 0.230819564800709 no 2606 0.253632917142093 3624 2876951 SGTC_2078 5212016 200 µM -0.663689955661035 0.230648630923232 no 2607 0.253444384681268 3559 1899708 SGTC_643 k048-0106 28.4 µM -0.664421970270461 0.230436255106865 no 2608 0.253210137528743 3623 6763920 SGTC_3076 9116187 49.47 µM -0.664456559193461 0.23042622269738 no 2609 0.25319907177396 3565 27241210 SGTC_2625 euphol 100 µM -0.664644338751192 0.230371762082252 no 2610 0.253139001414916 3620 6708538 A triterpene alcohol. SGTC_2854 9024559 71.43 µM -0.664775512127996 0.23033372289912 no 2611 0.253097043723676 3594 3163529 SGTC_2079 5212404 121 µM -0.665802551186147 0.230036011587945 no 2612 0.252768657004755 3630 758462 SGTC_1492 4158-0558 28.5 µM -0.668267879395969 0.229322258058845 no 2613 0.25198130646443 3615 3967268 SGTC_2999 9069765 71.4286 µM -0.669125731224503 0.229074187160441 no 2614 0.25170763861801 3634 2097066 SGTC_2839 9003951 25.97 µM -0.669589990065289 0.228939997050045 no 2615 0.251559598436702 3611 2990634 SGTC_1075 aripiprazole 15.2 µM -0.669684154546835 0.228912784980984 no 2616 0.251529577422221 3657 60795 An atypical antipschotic. YIL048W NEO1 SGTC_1673 st016611 27.3 µM -0.670356924669366 0.228718417710869 no 2617 0.251315143551748 3639 5226799 SGTC_671 0560-0003 407 µM -0.670436648031675 0.228695391302043 no 2618 0.251289739511862 3567 3238678 SGTC_393 acivicin 6.25 µM -0.672812954355846 0.22800964334791 no 2619 0.25053314761868 3551 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1 SGTC_1041 0206-0046 107 µM -0.672853321914268 0.227998004187946 no 2620 0.250520305430485 3623 50494 SGTC_1666 st014829 29 µM -0.673943563240399 0.22768378182348 no 2621 0.250173597384649 3650 3858230 SGTC_3116 9124943 49.47 µM -0.674223112585656 0.227603251189157 no 2622 0.250084738804654 3554 41905195 YPL160W CDC60 SGTC_1003 4049-0218 100 µM -0.675733822607429 0.227168333956914 no 2623 0.249604828854933 3662 295161 SGTC_1396 3511-0007 98.6 µM -0.677594523009184 0.226633302621598 no 2624 0.249014409861559 3597 X1396 SGTC_1722 st034304 3.6505 µM -0.680021764167687 0.225936436715022 no 2625 0.248245340123426 3665 4036148 YLR033W RSC58 SGTC_25 0118-0223 35.662 µM -0.680134586784769 0.225904074603423 no 2626 0.248209623181887 3672 5333628 SGTC_1974 st069448 26.9 µM -0.682222201634113 0.225305734980377 no 2627 0.247549229040989 3614 6323587 YNR016C ACC1 SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM -0.682889982057642 0.225114529390219 no 2628 0.247338182335961 3661 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis. SGTC_886 0866-0150 153 µM -0.68313408770178 0.225044657565577 no 2629 0.247261058696225 3676 271463 SGTC_2605 digitonin 300 nM -0.68338689349059 0.224972308402106 no 2630 0.247181199856142 3692 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_1070 indatraline 8.81 µM -0.684172099022216 0.224747678625717 no 2631 0.24693324919965 3636 10314472 A monamine transport inhibitor. YGL099W LSG1 SGTC_2259 7964009 200 µM -0.68592602809793 0.224246378303975 no 2632 0.246379877998916 3662 313134 SGTC_861 0443-0273 110 µM -0.687598573141256 0.223768930740963 no 2633 0.245852803501533 3669 6149169 SGTC_2529 gangaleoidin 93.61 µM -0.690432057058863 0.222961399797479 no 2634 0.244961261509693 3705 4565183 SGTC_1529 apigenin 74 µM -0.691630443822221 0.222620364747663 no 2635 0.244584719015058 3709 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_1185 1319-0113 81.3 µM -0.692488742651912 0.222376294265667 no 2636 0.244315226521778 3686 4672763 SGTC_2703 st077852 53.4 µM -0.694448507843406 0.22181957739544 no 2637 0.243700491103281 3653 6281836 SGTC_845 0330-0138 4.51 µM -0.695146904390106 0.221621374186184 no 2638 0.243481621400125 3635 9039800 SGTC_1563 conessine 56.1 µM -0.697031842005544 0.221086939057796 no 2639 0.242891433366714 3741 441082 An anti-amoebic, histamine inhibitor. SGTC_219 mitoxanthrone 164.414 µM -0.698043098007872 0.220800522529909 no 2640 0.242575120886066 3666 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA.  YMR168C CEP3 SGTC_1686 st019653 115.5 µM -0.698049710077232 0.220798650502811 no 2641 0.242573053419977 3672 97252 SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM -0.698437798565803 0.220688789755062 no 2642 0.242451722380874 3658 7104 SGTC_988 1497-1057 103 µM -0.700299652021658 0.220162168735912 no 2643 0.241870094514577 3673 3533044 SGTC_1791 st048313 56.1 µM -0.700544431377748 0.220092987096614 no 2644 0.241793683782031 3615 1204976 SGTC_602 3130-1533 38.1 µM -0.708138084721455 0.217953005913096 no 2645 0.239429755493564 3701 720941 SGTC_1483 3453-0561 55.9 µM -0.709109008040198 0.217680255980292 no 2646 0.239128416674703 3686 4546991 SGTC_1278 0874-0585 172 µM -0.7094255494028 0.217591376369719 no 2647 0.239030218723762 3733 766306 SGTC_2144 5628481 200 µM -0.710085930684112 0.2174060196006 no 2648 0.238825425210388 3682 2818399 SGTC_3019 9081971 49.47 µM -0.710896428593969 0.217178652532406 no 2649 0.238574209654895 3711 16451803 SGTC_3106 9121286 49.47 µM -0.712078350510721 0.216847337096846 no 2650 0.238208129826197 3711 15943471 SGTC_603 3794-0023 45.9 µM -0.712099725891549 0.216841347858068 no 2651 0.238201512006937 3690 3802260 SGTC_2127 5253358 187.912 µM -0.712271734744408 0.216793155609091 no 2652 0.23814826172205 3651 20612 SGTC_1514 1189-1591 158 µM -0.712731623120821 0.216664337687149 no 2653 0.238005922095065 3714 767698 YMR146C TIF34 SGTC_1646 st011709 75.6 µM -0.713752362304099 0.21637857980227 no 2654 0.237690160744451 3660 5757843 SGTC_542 3381-0244 89.3 µM -0.714351789300002 0.216210870783305 no 2655 0.237504837703786 3704 1112843 SGTC_2971 9092186 9.93 µM -0.715541263828718 0.215878299906957 no 2656 0.237137326396565 3694 25236400 SGTC_2216 7189485 200 µM -0.716814664974219 0.215522592353269 no 2657 0.236744230865987 3692 731273 SGTC_2819 7996655 46.38 µM -0.717267805611586 0.215396095637114 no 2658 0.236604434067182 3614 6456960 SGTC_2276 7947513 42.08 µM -0.717682995552595 0.215280230890356 no 2659 0.236476385183754 3591 2105100 SGTC_424 splitomicin 100 mM -0.719776013106402 0.214696695126585 no 2660 0.235831457986674 3749 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_2855 9016525 58.44 µM -0.720386968198329 0.214526533599217 no 2661 0.235643385728704 3718 43811474 SGTC_280 3448-3607 3.04 µM -0.72044260331418 0.214511042156096 no 2662 0.235626263503881 3691 626179 SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM -0.721240147320419 0.214289039745726 no 2663 0.235380887357816 3763 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_2657 nystatin 74.44 µM -0.722388518596347 0.213969616783419 no 2664 0.235027821921934 3727 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_2674 ligustilide 100 µM -0.722510233529514 0.21393577765789 no 2665 0.234990417960735 3698 5319022 A signalling regulator. SGTC_2119 5528445 120.635 µM -0.723155216513961 0.213756511814217 no 2666 0.234792264492992 3719 791935 SGTC_1116 jasmonic acid  1.58368 µM -0.726451009433462 0.21284184959757 no 2667 0.233781165088716 3736 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid. SGTC_2476 5806916 10.51 µM -0.727122281894542 0.212655835681883 no 2668 0.23357552507156 3637 2870194 SGTC_1930 st074634 34.3 µM -0.728053432931972 0.212397964977228 no 2669 0.233290439068411 3666 684253 YOR116C RPO31 SGTC_1920 st075728 45.7 µM -0.728930743844334 0.212155171878511 no 2670 0.233022013801963 3712 3400306 SGTC_3169 9102970 49.47 µM -0.729659789881257 0.21195353412814 no 2671 0.232799082749004 3782 17027839 SGTC_627 1391-0720 175 µM -0.731157010546945 0.211539788200293 no 2672 0.232341627535247 3721 997839 SGTC_771 0250-0039 27.3 µM -0.731967210405523 0.211316092742955 no 2673 0.232094290765179 3716 3005115 SGTC_881 0833-0569 170 µM -0.732900608460506 0.211058554229348 no 2674 0.231809525991535 3746 5418700 SGTC_2372 9071633 200 µM -0.733021026356865 0.211025342530446 no 2675 0.231772802602728 3773 21321366 SGTC_359 0081-0058 15.9 µM -0.733546815894988 0.21088036373713 no 2676 0.2316124925416 3772 3494159 SGTC_1621 st003705 32.4 µM -0.734248802190774 0.210686892332252 no 2677 0.23139855751767 3744 24207032 SGTC_2501 sodium tetradecyl sulfate 13.37 µM -0.735526731619471 0.210334955187715 no 2678 0.231009383015851 3768 23665772 A membrane-active detergent. SGTC_2826 7992541 19.48 µM -0.737807830961813 0.209707607352123 no 2679 0.230315616966204 3783 2985066 SGTC_2278 7948257 134.34 µM -0.739618018946508 0.20921055343331 no 2680 0.229765902500676 3701 1247028 SGTC_2952 9073731 13.78 µM -0.740569954362826 0.20894944293221 no 2681 0.229477115588608 3786 16457353 SGTC_430 0958-0115 16.4 µM -0.742230898047708 0.208494315420982 no 2682 0.228973725535173 3727 6833180 SGTC_1753 st043925 64 µM -0.742431105725088 0.208439494534658 no 2683 0.228913089520228 3774 670181 SGTC_3199 9111318 49.47 µM -0.744891163851289 0.207766575427952 no 2684 0.228168758638426 3713 8548020 SGTC_69 0096-0274 206.684 µM -0.745837066286765 0.207508177207067 no 2685 0.227882922973305 3848 6741392 SGTC_1489 4065-0444 182 µM -0.745925838388462 0.207483936516995 no 2686 0.227856107895694 3710 2877968 SGTC_218 alverine citrate 93.75 µM -0.746375207554258 0.207361254519398 no 2687 0.227720395771684 3786 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_2919 7978188 46.38 µM -0.746386016836846 0.207358304012172 no 2688 0.22771713186541 3719 2980291 SGTC_1949 st076024 69.1 µM -0.74664169753775 0.207288520516697 no 2689 0.227639935729716 3726 2921930 SGTC_1299 1079-1439 3.74 µM -0.749059827374883 0.206629222056107 no 2690 0.226910573347253 3733 323161 SGTC_1641 st009299 47.1 µM -0.750168580062599 0.206327338484919 no 2691 0.226576589819096 3690 4046054 SGTC_2469 5655019 90.81 µM -0.751257610777941 0.206031079277616 no 2692 0.226248817343069 3808 2788239 SGTC_2459 5811157 9.22 µM -0.751830367674586 0.205875368146372 no 2693 0.226076538621496 3739 2870684 YBR192W RIM2 SGTC_1055 3448-0672 86 µM -0.753819440959097 0.205335156164833 no 2694 0.225478824339678 3761 748378 SGTC_3135 9127742 49.47 µM -0.755731386820485 0.204816685688222 no 2695 0.224905130876966 3825 3643468 SGTC_356 1634-0012 32.5 µM -0.757198588613885 0.204419346816817 no 2696 0.224465447832681 3741 735457 SGTC_1583 clindamycin 39.6 µM -0.757359279415771 0.204375857383799 no 2697 0.224417322543204 3741 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis. SGTC_281 1672-3440 14.9 µM -0.759397175454729 0.203824798260275 no 2698 0.22380750132669 3808 6833000 SGTC_1073 triclabendazole 3.09 µM -0.760494340124777 0.203528485565202 no 2699 0.223479575571492 3846 50248 An antihelmetic and likely tubulin inhibitor. SGTC_543 3844-1095 191 µM -0.761724258187785 0.20319662561791 no 2700 0.223112297008137 3788 4230703 SGTC_2626 ethyl orsellinate 100 µM -0.761954791330382 0.203134458481118 no 2701 0.223043493387239 3785 75653 A natural product. SGTC_1039 k821-0043 94 µM -0.766080480677796 0.202023818034562 no 2702 0.221814208241816 3740 15992768 SGTC_1023 4482-3888 16 µM -0.766960992167646 0.201787254753677 no 2703 0.221552354159504 3766 3303168 SGTC_1692 fluoroquinolonic acid 71 µM -0.768529300965366 0.201366314960781 no 2704 0.221086394884075 3814 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2 SGTC_2082 5219693 150 µM -0.770093216618091 0.200947078859238 no 2705 0.220622299774889 3779 2834649 SGTC_1797 st048695 56.8 µM -0.770475896869992 0.200844574242662 no 2706 0.220508823690533 3748 592262 YIL048W NEO1 SGTC_370 0180-0345 38.7 µM -0.771596915056372 0.200544479293585 no 2707 0.220176600992186 3712 3989527 SGTC_3339 9145883 14.936 µM -0.771970370967561 0.200444565508605 no 2708 0.220065988124807 3701 2030670 SGTC_1332 1480-0653 17.5 µM -0.772628686095557 0.200268513775512 no 2709 0.219871081243406 3745 5749438 SGTC_307 1501-1223 22.3 µM -0.773189253661316 0.200118675720485 no 2710 0.219705192539612 3785 2830329 SGTC_1356 1502-0781 85.8 µM -0.773236622546523 0.200106017245746 no 2711 0.219691177963683 3756 567702 SGTC_112 phenothiazine 287.218 µM -0.774498493790675 0.199768982278445 no 2712 0.219318029280724 3748 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.  SGTC_3319 9138450 16.7555 µM -0.776724617890531 0.199175236889766 no 2713 0.218660629700828 3749 2029690 SGTC_391 gliotoxin 8.33 µM -0.777196765041941 0.199049443935531 no 2714 0.218521345256601 3891 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion SGTC_1114 scopoletin 1.73284 µM -0.779572156302265 0.198417301093698 no 2715 0.21782137514675 3795 5280460 A coumarin with genotoxic properties. SGTC_651 3253-0966 34.4 µM -0.780132026821268 0.198268484061034 no 2716 0.217656583428933 3829 781462 SGTC_1801 st050089 28.441 µM -0.781115616657914 0.198007203021018 no 2717 0.217367248872585 3828 5008493 YIL048W | YNL267W NEO1 | PIK1 SGTC_1495 4469-0029 237 µM -0.781804254827867 0.197824396832794 no 2718 0.217164810071475 3798 793680 SGTC_2594 a-mangostin 100 µM -0.783127292507865 0.197473468941762 no 2719 0.216776182789817 3844 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis. SGTC_548 1436-0017 110 µM -0.784657192175705 0.197068141766487 no 2720 0.216327293924522 3859 9677137 SGTC_1862 st057513 3.81 µM -0.786783625026922 0.196505607811437 no 2721 0.215704270416589 3798 5393163 SGTC_2811 7967822 32.47 µM -0.788392700909652 0.196080584683585 no 2722 0.215233519471146 3886 2232244 SGTC_945 3381-0768 11.3 µM -0.788588158243382 0.196028994367062 no 2723 0.215176377150961 3837 1126236 YIL048W NEO1 SGTC_1980 st071811 45.7 µM -0.78914160202254 0.195882959383798 no 2724 0.215014624594855 3936 4974850 SGTC_2547 epiafzelechin trimethyl ether 100 µM -0.789704257817788 0.195734561353826 no 2725 0.2148502520863 3650 6708630 An antioxidant. SGTC_1424 4048-1941 275 µM -0.79051802646422 0.195520054155888 no 2726 0.214612649432784 3886 X1424 SGTC_2308 7584454 197.62 µM -0.79064877774916 0.195485601789897 no 2727 0.214574487162484 3835 893577 SGTC_2229 7354935 190 µM -0.790912274544292 0.195416182791515 no 2728 0.214497592554972 3745 318112 SGTC_122 0236-0016 402.397 µM -0.792314692377886 0.195046963720901 no 2729 0.214088603443812 3841 6808838 SGTC_1400 3771-8998 51.5 µM -0.795325286849048 0.194255788445472 no 2730 0.213212153953498 3742 670767 SGTC_935 2996-0153 430 µM -0.798128091303934 0.19352097922183 no 2731 0.212398080642465 3795 23738523 SGTC_1306 1185-0270 9.02 µM -0.798339632947143 0.19346558839707 no 2732 0.212336712264201 3850 1548076 SGTC_2708 st078559 56 µM -0.799139671858716 0.193256190802236 no 2733 0.212104714135211 3798 17250902 SGTC_2269 7935389 174.42 µM -0.801320412106827 0.192686119134987 no 2734 0.211473088419344 3784 97605 SGTC_3300 9124615 50.48 µM -0.803868066466124 0.192021434746154 no 2735 0.210736587142315 3877 24824903 SGTC_1309 pyrazolanthrone 13.4 µM -0.806060470587218 0.191450560129455 no 2736 0.210103991354464 3841 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14 SGTC_33 0986-0033 35.816 µM -0.809259685317037 0.190619392864718 no 2737 0.209182895065098 3757 2848082 SGTC_2282 7944268 200 µM -0.80973366857912 0.190496439010178 no 2738 0.209046631493372 3838 2970414 SGTC_2949 9072542 2.23 µM -0.810271341841457 0.19035702258614 no 2739 0.208892121235207 3926 16457352 SGTC_3157 9099274 49.47 µM -0.811769008462847 0.189969014420452 no 2740 0.208462094164117 3803 17217662 SGTC_1450 4112-4260 37.6 µM -0.812250437279479 0.189844391520392 no 2741 0.208323971805065 3810 1633175 SGTC_544 k015-0020 52.4 µM -0.814270958682189 0.189321906779039 no 2742 0.207744871439789 3862 3008304 SGTC_150 3970-0969 77.2 µM -0.814786679258352 0.189188689010785 no 2743 0.207597213561542 3952 6615640 SGTC_1626 st003712 1.76 µM -0.815054839581817 0.189119442300022 no 2744 0.207520460093839 3824 24207035 SGTC_1271 0832-2808 169 µM -0.81790352037198 0.188384794932653 no 2745 0.206706140008562 3908 3663794 SGTC_2918 7977171 22.06 µM -0.819149977918532 0.188063899898071 no 2746 0.206350425214262 3779 2236483 SGTC_2641 levomentholum 100 µM -0.819680518653548 0.187927416938608 no 2747 0.206199129313109 3815 16666 SGTC_3316 9136639 10.545 µM -0.821346132303571 0.187499331100254 no 2748 0.205724568741494 3899 4903665 SGTC_2650 prasterone 100 µM -0.822613656198849 0.187173964000074 no 2749 0.205363865144765 3825 16759247 A steroid and weak partial agonist of the androgen receptor. SGTC_910 3454-3003 490 µM -0.823646553310029 0.186909082802019 no 2750 0.205070208053613 3780 820824 SGTC_483 fpl-64176 144 µM -0.823669337113804 0.186903242627548 no 2751 0.205063733334773 3891 3423 SGTC_406 estrone 100 µM -0.824172799021598 0.186774219009139 no 2752 0.204920690153064 3833 5870 A steroid. SGTC_1834 st055981 52.8 µM -0.825155036700102 0.186522656904182 no 2753 0.20464178842812 3930 471719 YDL150W RPC53 SGTC_1031 k035-0009 16 µM -0.825438086261273 0.186450203695294 no 2754 0.204561459784201 3948 5180959 SGTC_1200 1643-0193 18.4 µM -0.825634236805317 0.186400004566082 no 2755 0.204505803837246 3846 5403974 SGTC_464 bw-b 70c 158 µM -0.825773906037254 0.186364265319139 no 2756 0.204466179446446 3944 5353454 SGTC_1798 st045719 60.953 µM -0.827199945832602 0.185999606256363 no 2757 0.204061871177826 3779 3980186 SGTC_1671 st016596 74.5 µM -0.828134627856231 0.185760834674441 no 2758 0.203797130366673 3921 2829167 SGTC_2896 9052656 71.43 µM -0.828648641446464 0.185629607089516 no 2759 0.203651627641171 3808 6469436 SGTC_1232 0279-0259 161 µM -0.829338695943258 0.185453526759653 no 2760 0.203456390137584 3880 1560000 SGTC_537 1334-0398 209 µM -0.829770305627846 0.185343446184034 no 2761 0.203334331349108 3839 5846986 SGTC_185 k048-0037 25.491 µM -0.830081198430564 0.18526417917708 no 2762 0.203246438253305 3904 6827589 SGTC_2506 ethyl hematommate 54.16 µM -0.83333032744639 0.184437022756808 no 2763 0.20232922835993 3963 3940691 An allergen. SGTC_2536 dehydroabietamide 32.04 µM -0.836066160374916 0.183742324699372 no 2764 0.201558842115085 3942 3983547 SGTC_1336 1486-0901 104 µM -0.836775050968431 0.183562585477565 no 2765 0.201359511874569 3898 5006114 SGTC_2667 digitoxin 100 µM -0.837411216134872 0.183401379113689 no 2766 0.201180731654624 3846 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_2812 7970281 58.44 µM -0.837937016143938 0.183268206289689 no 2767 0.201033039003855 3928 2233435 SGTC_2366 9070441 60.58 µM -0.838204596880176 0.183200457516843 no 2768 0.200957902879032 3889 6837235 SGTC_2045 5106652 78.05 µM -0.839051266831499 0.182986192057745 no 2769 0.200720270701714 3862 673349 SGTC_1685 st024049 53.0905 µM -0.842613615156456 0.182086388154289 no 2770 0.199722286982094 3920 1941139 SGTC_3295 9122362 53.5725 µM -0.842743690016241 0.182053585328903 no 2771 0.199685903388774 3951 4730473 SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM -0.842931392790531 0.182006256166573 no 2772 0.199633407564453 3893 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_773 4358-1457 44.6 µM -0.843481068251034 0.181867700028687 no 2773 0.199479724705463 3865 1186886 SGTC_57 miconazole 162.5 nM -0.844211253944243 0.181683744916299 no 2774 0.199275683458448 3846 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_329 k048-0121 21.3 µM -0.844278857745788 0.18166671943367 no 2775 0.199256798781931 3911 6832902 SGTC_2415 st077333 57.7 µM -0.844825260975605 0.181529148746947 no 2776 0.199104204203222 3875 2766255 SGTC_1084 voriconazole 435 nM -0.847149458914203 0.180944702610859 no 2777 0.198455910148178 3890 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_2306 7482397 179.52 µM -0.851512286235643 0.179850808290301 no 2778 0.19724242064553 3895 891448 SGTC_73 0327-0325 16.231 µM -0.851648901861318 0.179816621778881 no 2779 0.1972044946019 3838 53298 SGTC_631 k072-0230 41.5 µM -0.852439548867418 0.179618851510114 no 2780 0.196985088713968 3923 5773147 SGTC_2900 5328528 85.29 µM -0.854587697962309 0.179082209943008 no 2781 0.196389720223143 3926 795359 SGTC_2380 9035439 200 µM -0.856426072261026 0.178623756870516 no 2782 0.195881074199083 4030 6462575 SGTC_1875 nocodazole 6 µM -0.860444493709357 0.177624220620801 no 2783 0.194772034091542 3887 4122 A microtubule depolymerizer. YJL014W CCT3 SGTC_146 3448-8650 53.125 µM -0.863136821637597 0.176956513456514 no 2784 0.19403112249191 3893 2891488 YIL048W NEO1 SGTC_2717 st081029 62.2815 µM -0.864976815227201 0.176501101940692 no 2785 0.19352575710555 3910 5292846 SGTC_1076 itraconazole 331 nM -0.86566283513195 0.176331497022085 no 2786 0.193337543238883 3916 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1 SGTC_3200 9114385 49.47 µM -0.866051943046108 0.176235343597669 no 2787 0.193230838702199 3979 17018030 YLR208W SEC13 SGTC_385 1494-0393 12.4 µM -0.866736167314419 0.176066343731092 no 2788 0.193043292003517 3918 3090647 SGTC_2323 6148992 148.28 µM -0.868925510366741 0.175526276939304 no 2789 0.192443937626978 3911 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42 SGTC_1124 fisetin 1.16336 µM -0.870375114906493 0.175169267095396 no 2790 0.192047720770263 3954 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster. SGTC_389 tpck 16.7 µM -0.870869848037919 0.17504752928532 no 2791 0.191912610913616 3941 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.  SGTC_563 tetrahydrosecaminediol 614 µM -0.872255937210446 0.174706743536543 no 2792 0.191534384866406 3994 334274 A psychoactive constituent of the cannabis plant. SGTC_813 k007-0158 173 µM -0.872839087015265 0.174563495505239 no 2793 0.191375395711556 3941 6523916 SGTC_1747 st037496 66.6 µM -0.874102944806894 0.174253290821287 no 2794 0.191031096973548 3941 723305 SGTC_3228 9131799 49.47 µM -0.874171999520825 0.174236351943539 no 2795 0.191012296116574 3948 17015818 SGTC_283 0987-0079 11.7 µM -0.878183532277679 0.173254133453874 no 2796 0.189922063618792 3955 411556 SGTC_49 0717-0965 32.132 µM -0.878663857294432 0.173136763316975 no 2797 0.189791780442083 3974 5889349 YGL099W LSG1 SGTC_722 3534-0461 190 µM -0.879748988126444 0.172871791943984 no 2798 0.18949765235877 3991 658262 SGTC_1832 st054113 55 µM -0.880022237503088 0.172805109623277 no 2799 0.189423631497238 3950 1251267 SGTC_2094 5332512 191.667 µM -0.880864874069474 0.17259958033094 no 2800 0.189195480705328 3992 755774 SGTC_2928 9011484 9.79 µM -0.881079292521107 0.172547305953703 no 2801 0.189137452160145 3979 2994751 SGTC_2934 9036370 36.88 µM -0.885091870946679 0.171570917814532 no 2802 0.188053541719424 3966 6462800 SGTC_2454 5-benzylidenerhodanine 10.36 µM -0.885189278638175 0.171547259394589 no 2803 0.188027276917215 4011 1273210 SGTC_443 clozapine 122 µM -0.885785703205283 0.171402445013272 no 2804 0.187866507653941 3827 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_660 4031-1742 102 µM -0.887312315100158 0.171032133338562 no 2805 0.187455388541305 3885 6738706 SGTC_275 trichlorophene 5.69 µM -0.889247482078722 0.170563454182461 no 2806 0.186935044744752 3987 62616 SGTC_1123 mangostin 811.285 nM -0.889662841248771 0.170462965408109 no 2807 0.186823476123491 3981 5281650 An antioxidant. SGTC_2525 harmine 47.85 µM -0.892609376226366 0.169751192392163 no 2808 0.186033198121135 3953 5280953 A monoamine oxidase inhibitor SGTC_1224 0823-0416 294 µM -0.892906194580268 0.169679597965446 no 2809 0.18595370475423 4040 3598164 SGTC_1044 1222-0021 1.78 µM -0.894186799266602 0.169370930261846 no 2810 0.185610976991109 3940 4306703 SGTC_1679 SEC14.276 6.7 µM -0.895590849061386 0.169032922681502 no 2811 0.185235662432634 3978 1005053 YMR079W SEC14 SGTC_31 0508-1974 57.237 µM -0.901517037764871 0.167611043563102 no 2812 0.183656739569586 3923 6810525 SGTC_539 4859-0462 2.54 µM -0.902126919396939 0.167465152244507 no 2813 0.183494725218879 4029 46499474 YNL221C | YBR257W POP1 | POP4 SGTC_1541 2',3',6-trimethoxyflavone 64 µM -0.902440308694216 0.167390217434919 no 2814 0.183411508374407 4062 688801 SGTC_2810 7959871 45.46 µM -0.902466995854276 0.167383837241464 no 2815 0.183404422999959 3949 2974535 SGTC_1408 3909-7976 48.8 µM -0.902751035960538 0.167315940481912 no 2816 0.183329021633639 4022 24152374 SGTC_1982 st072467 71.9 µM -0.903029941835613 0.167249288279824 no 2817 0.183255002012521 3956 3163533 SGTC_600 1495-0418 41.6 µM -0.90343000807473 0.16715371137441 no 2818 0.183148859844533 3953 5377768 SGTC_249 wiskostatin 11.211 µM -0.903517889226059 0.167132721047944 no 2819 0.183125549103862 3931 2775510 A n-wasp and actin depolymerizer. SGTC_377 3970-0964 33.1 µM -0.903521977468141 0.167131744616718 no 2820 0.183124464730362 3933 16481235 SGTC_350 k064-0020 19.8 µM -0.905074687912098 0.166761162939218 no 2821 0.182712910389268 3970 2790705 SGTC_524 r073-0010 27.8 µM -0.90770934479092 0.166133569693259 no 2822 0.182015902724666 3901 2772106 SGTC_892 0929-0076 29 µM -0.908744336750492 0.165887445529549 no 2823 0.181742547428833 3963 5751038 SGTC_2238 6671620 73.2395 µM -0.909636674922194 0.165675434147992 no 2824 0.181507075207569 3922 729941 SGTC_2617 dihydrotanshinone i 20.83 µM -0.912735840441077 0.164940462414876 no 2825 0.180690744650364 3987 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12 SGTC_2340 7987427 183.45 µM -0.915057140276194 0.164391347824429 no 2826 0.180080816835562 4021 2239331 SGTC_1992 st073643 23.3 µM -0.91585226171933 0.164203530847997 no 2827 0.179872194070465 3936 3161292 SGTC_2326 6164455 177.58 µM -0.916499806414216 0.164050676079596 no 2828 0.179702404471168 3990 2888790 SGTC_1344 1488-0097 29.1 µM -0.917004252992316 0.163931664012587 no 2829 0.179570205748332 4019 747966 SGTC_967 1306-0166 352 µM -0.917030053470367 0.163925578515138 no 2830 0.179563445941882 3953 4437607 SGTC_418 lividomycin a 100 µM -0.917719958651949 0.163762906587296 no 2831 0.179382747932221 3979 72394 An antibiotic. SGTC_1835 st008666 49.2 µM -0.917781386317387 0.163748427712448 no 2832 0.179366664517022 3941 690455 SGTC_1537 2',6'-dihydroxyflavanone 78 µM -0.921715917369471 0.162822766047498 no 2833 0.178338387834383 3994 5106787 A p450 inhibitor. SGTC_2532 xanthone 78.9 µM -0.921815417205107 0.162799401313119 no 2834 0.178312432127955 4005 7020 An insecticide. SGTC_1655 st012546 55.1 µM -0.922660643455988 0.162601011668143 no 2835 0.178092040891587 3990 720985 YLR208W SEC13 SGTC_1096 rimcazole 32.2 µM -0.924016377166113 0.162283125455067 no 2836 0.177738894554586 3931 18528119 A dopamine reuptake inhibitor. SGTC_747 3448-8087 38.7 µM -0.924230805878446 0.162232884275906 no 2837 0.177683079892291 4034 5168703 SGTC_933 2914-0560 114 µM -0.924598611521215 0.162146730086787 no 2838 0.177587367781198 4059 463887 SGTC_1263 0774-1208 64.8 µM -0.925069052181502 0.162036578271446 no 2839 0.177464994936585 4033 906585 SGTC_1913 st060213 96.1 µM -0.925775563793144 0.161871242961481 no 2840 0.177281314428883 4051 688959 SGTC_3069 9117009 49.47 µM -0.925941082980396 0.161832524652916 no 2841 0.177238299735139 3963 41904981 SGTC_2689 tacrolimus 100 µM -0.928091420827144 0.161330065331275 no 2842 0.176680074727359 4021 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). SGTC_24 0417-1663 219 µM -0.930458721490061 0.160778087289998 no 2843 0.176066813506571 4007 4329390 SGTC_205 1486-1330 71.903 µM -0.931359161781647 0.160568457805219 no 2844 0.175833904094155 4014 4118834 SGTC_173 1273-0061 2.693 µM -0.931442731341079 0.160549011221612 no 2845 0.175812297750976 4002 2847414 YPL266W DIM1 SGTC_289 k017-0060 526 µM -0.931547669053333 0.160524594461331 no 2846 0.175785169198497 3978 5512909 SGTC_3147 9097027 49.47 µM -0.935792082035426 0.159539043868472 no 2847 0.174690124505539 4029 25236841 SGTC_874 0599-0792 117 µM -0.935960008243592 0.159500133105677 no 2848 0.174646889342365 4032 765305 SGTC_2744 captopril 92.04 µM -0.93600101484866 0.1594906322671 no 2849 0.174636332598752 4032 44093 angiotensin-converting enzyme (ACE) inhibitor  SGTC_1085 doxorubicin 7.67 µM -0.939287880319139 0.158730301879267 no 2850 0.173791479721498 4032 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_978 1416-0512 87.4 µM -0.943571839304856 0.15774289275149 no 2851 0.172694244184809 4105 6814003 SGTC_2550 chrysin dimethyl ether 71.87 µM -0.943736610694791 0.157704995364302 no 2852 0.172652130244225 3815 88881 An O-methylated flavonoid and antioxidant. SGTC_626 0214-0009 33 µM -0.944475695211214 0.157535079658788 no 2853 0.172463308101043 4092 3437874 SGTC_1510 1123-0200 71.5 µM -0.9481168621324 0.156699731408018 no 2854 0.171534982459991 4102 5378812 YNL149C | YNL150W PGA2 | YNL150W SGTC_1147 3809-1045 12.3 µM -0.948129606877487 0.156696812667156 no 2855 0.17153173876967 4001 325925 SGTC_2210 7115885 190.385 µM -0.953089404653269 0.155563659946529 no 2856 0.17027238699918 4088 2927039 SGTC_1843 st055809 45.5 µM -0.955004324243302 0.155127612986178 no 2857 0.169787755089106 4105 16413835 SGTC_2161 5662504 8.5105 µM -0.955726904473233 0.154963283905738 no 2858 0.169605113044836 4012 2859334 SGTC_2523 spermine 47.74 µM -0.957108564281197 0.154649387244225 no 2859 0.169256230668964 4050 1103 A DNA binding polyamine. SGTC_979 1426-2828 121 µM -0.95713735292885 0.154642851277969 no 2860 0.169248966162085 4141 747872 SGTC_3111 9122088 49.47 µM -0.958329506827167 0.154372353577797 no 2861 0.16894831467336 3895 16876704 SGTC_2405 ticlatone 3.52 µM -0.959182641518025 0.15417897091764 no 2862 0.168733371797958 3903 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W SGTC_2012 4023501 200 µM -0.960651698126542 0.153846351010159 no 2863 0.168363662622566 4064 3477460 SGTC_562 3772-2733 112 µM -0.962468026579378 0.153435759818091 no 2864 0.167907278339386 4062 2876874 YIL048W NEO1 SGTC_2193 5925765 200 µM -0.962702250007861 0.153382865187687 no 2865 0.16784848362998 4037 877370 SGTC_2220 6782180 200 µM -0.962770625105433 0.153367426331072 no 2866 0.167831322628898 3962 833803 SGTC_80 0159-0065 512.242 µM -0.963781092098778 0.153139386464714 no 2867 0.167577844093498 3921 1548079 SGTC_3064 1327-0027 10 µM -0.964912217084124 0.152884383487892 no 2868 0.167294390843471 3941 16000455 YPR107C YTH1 SGTC_2989 9073649 71.4286 µM -0.965295184369791 0.152798110450626 no 2869 0.167198491564883 3948 21367202 SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM -0.966921419052491 0.152432119798649 no 2870 0.166791659108695 3963 5355888 SGTC_2944 9067346 25.62 µM -0.968340272208586 0.152113276817409 no 2871 0.166437229088417 4015 6473075 SGTC_1426 4048-4480 71.7 µM -0.970417842747093 0.151647207248963 no 2872 0.165919129200691 4044 14224343 SGTC_2027 5150920 200 µM -0.970726016717589 0.151578154294887 no 2873 0.165842366335738 3996 786715 SGTC_737 1950-0117 57.9 µM -0.970877036178736 0.151544322794616 no 2874 0.165804757373659 4021 5393513 SGTC_1009 4106-0057 9.87 µM -0.97148978349353 0.151407106159785 no 2875 0.165652219106263 4044 2928005 SGTC_624 k048-0052 28 µM -0.972219382673941 0.151243829886811 no 2876 0.165470709947189 4041 6835531 SGTC_295 k015-0027 31 µM -0.972834374574553 0.151106292467113 no 2877 0.165317812670899 4086 3887424 SGTC_1251 0490-5699 265 µM -0.973612032581695 0.150932495415722 no 2878 0.165124604809486 4117 3883818 SGTC_153 4077-0274 519.67 µM -0.974403493762852 0.150755750186879 no 2879 0.164928117717883 4052 3121976 SGTC_2472 5377652 49.4 µM -0.974411174960022 0.150754035535072 no 2880 0.164926211536325 4134 1610903 SGTC_2364 9055074 200 µM -0.974838228302859 0.150658726060398 no 2881 0.164820255554506 4091 6470630 SGTC_28 pentachloropyridine N-oxide 1.606 µM -0.975444148699991 0.150523566029108 no 2882 0.164669996637889 4049 140250 A respiratory chain inhibitor. SGTC_1590 st077108 57.8 µM -0.976765543507499 0.150229088445743 no 2883 0.164342619033516 4090 5489485 SGTC_1395 3486-0190 4.35 µM -0.976809145856183 0.150219378053942 no 2884 0.164331823680921 4042 6748079 SGTC_1878 temozolomide 1 mM -0.977475081426657 0.150071123915699 no 2885 0.164167004164448 3959 5394 DNA alkylating agent. SGTC_3336 9143619 71.43 µM -0.97756776172078 0.150050498668173 no 2886 0.164144074229153 4095 45595730 SGTC_176 1486-1328 72.834 µM -0.978987011110542 0.149734892296466 no 2887 0.163793198696454 4134 22310231 SGTC_1449 4112-4002 201 µM -0.979410124313352 0.149640888016847 no 2888 0.163688688325385 4123 2059539 SGTC_200 k038-0079 37.545 µM -0.979774066151755 0.149560061518969 no 2889 0.163598828119006 4032 3436683 SGTC_2551 apiole 73.87 µM -0.983830108069364 0.148661242000821 no 2890 0.162599526501125 3937 10659 A possible DNA adduct former. SGTC_1705 st027868 56.3335 µM -0.984738339166649 0.148460473689987 no 2891 0.162376307667288 4022 292948 SGTC_1553 gossypol 38.6 µM -0.986453314741029 0.148081865771261 no 2892 0.161955356845758 3938 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_1414 3917-0015 5.4 µM -0.98852483354356 0.147625407661211 no 2893 0.161447839207845 4040 6618702 SGTC_2707 st078556 66.6 µM -0.98861543411995 0.147605465404328 no 2894 0.161425665958297 4033 17250899 SGTC_3003 9075612 71.4286 µM -0.990485950484396 0.147194145865496 no 2895 0.160968326469087 4098 6501993 SGTC_943 3253-1379 105 µM -0.991153897642937 0.147047453142695 no 2896 0.160805219135572 4108 668464 SGTC_2739 tacrine 100.86 µM -0.991770124303939 0.146912206099638 no 2897 0.160654837265585 4122 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders. SGTC_1035 k081-0041 55.2 µM -0.994246269216379 0.146369592794826 no 2898 0.160051493586714 4111 731709 SGTC_234 nsc-17383 10.7 µM -0.997728065006329 0.145608883838399 no 2899 0.159205620176166 4092 408974 SGTC_1040 k898-0338 155 µM -0.998357163436123 0.14547172134645 no 2900 0.159053098813781 4106 20969351 SGTC_427 1354-0053 47.3 µM -1.00049328881962 0.145006630033838 no 2901 0.15853592191821 4172 6813657 SGTC_593 1203-0218 61.7 µM -1.00189857795373 0.144701207639941 no 2902 0.158196289751799 4116 3666956 SGTC_3018 9082602 49.47 µM -1.00339038933365 0.144377455143378 no 2903 0.157836269660591 4056 17332089 SGTC_619 1652-1634 108 µM -1.0049507949034 0.144039339102687 no 2904 0.157460271885648 4069 5400454 SGTC_214 4373-3496 70 µM -1.00649448703485 0.143705370456037 no 2905 0.157088881126816 4161 3779166 SGTC_611 3453-1652 23.7 µM -1.00779189468576 0.143425088435826 no 2906 0.156777188914403 4120 1560575 SGTC_2524 avocatin b 10.57 µM -1.01139381696114 0.142648892457421 no 2907 0.155913989653883 4071 6710748 SGTC_864 0469-0573 172 µM -1.01363235002613 0.142167933641555 no 2908 0.155379107660981 4081 689425 SGTC_1804 st050076 49.1 µM -1.01428754637651 0.142027369636944 no 2909 0.155222782368989 4136 3895976 SGTC_101 0490-5701 117.494 µM -1.01616818512653 0.141624425340553 no 2910 0.154774651897785 3893 4661669 SGTC_855 0428-0020 25 µM -1.01935374922702 0.140943657151405 no 2911 0.154017527588714 4140 6812414 SGTC_410 α-linolenic acid 100 µM -1.0196699877597 0.140876196991249 no 2912 0.153942499990572 4175 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_362 0310-0100 9.03 µM -1.02050852885357 0.140697425051947 no 2913 0.153743673207395 4188 790235 SGTC_180 1486-1293 102.781 µM -1.02572646035389 0.139588453655036 no 2914 0.152510269147715 4003 4140536 SGTC_102 gallobenzophenone 83.616 µM -1.02577065087405 0.139579087260792 no 2915 0.152499851599556 4128 70837 SGTC_764 1951-2361 146 µM -1.02690672849907 0.139338436850951 no 2916 0.152232192850288 4101 5438930 SGTC_2866 9034245 58.44 µM -1.02699637649316 0.139319459127851 no 2917 0.152211085157816 4076 6462273 SGTC_1458 k015-0034 6.33 µM -1.02793785805794 0.139120261647696 no 2918 0.151989529929201 4153 3598957 SGTC_1948 st076329 66.6 µM -1.02991399569026 0.138702783664701 no 2919 0.151525190077697 3980 24208413 SGTC_2748 diazoxide 86.69 µM -1.03273583397502 0.138108123972645 no 2920 0.150863769591861 4165 3019 A potassium channel activatior. SGTC_442 cape 100 µM -1.03276469492774 0.138102050959067 no 2921 0.150857014716788 4113 5281787 SGTC_2721 ifenprodil 61.44 µM -1.03376378352582 0.137891931817355 no 2922 0.150623303219514 4129 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor. SGTC_1545 lovastatin 49.4 µM -1.03438461641948 0.137761473865853 no 2923 0.150478196612107 4184 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12 SGTC_395 anisomycin 6.25 µM -1.03516439744233 0.137597734904691 no 2924 0.150296071210648 4138 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_3010 9080089 71.4286 µM -1.03574624035751 0.137475645697099 no 2925 0.150160271903213 4149 17027233 SGTC_3071 9117417 49.47 µM -1.03879331573279 0.136837480068788 no 2926 0.149450435364642 4089 45595590 YGL055W OLE1 SGTC_1285 0929-0069 65.5 µM -1.04365117623763 0.135824264972524 no 2927 0.14832340319132 4161 1206237 SGTC_3217 9129673 49.47 µM -1.04398254660049 0.135755337970504 no 2928 0.148246732361713 4179 17248312 SGTC_3253 9135987 49.47 µM -1.04544416338051 0.135451598913098 no 2929 0.147908867173843 4152 4182430 SGTC_1997 st073024 93.8 µM -1.04626612897728 0.135280990721504 no 2930 0.147719089449177 4140 686268 SGTC_2311 7694451 200 µM -1.04788473735252 0.134945461172196 no 2931 0.14734585751742 4125 2163142 SGTC_2552 juarezic acid 87.02 µM -1.04877021736182 0.13476214728162 no 2932 0.147141943973132 4107 1549512 SGTC_3144 9087057 49.47 µM -1.04903285245948 0.13470780889521 no 2933 0.147081499214982 4017 17249618 SGTC_823 0417-1665 178 µM -1.05062785697933 0.134378130352425 no 2934 0.146714770844257 4136 3429856 SGTC_2574 2',4'-dihydroxychalcone 14.64 µM -1.05436282880617 0.133608301481584 no 2935 0.145858416828426 4143 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_1762 st045503 25.4615 µM -1.05864193556725 0.132730052968586 no 2936 0.144881440444445 4237 4645554 SGTC_1885 st057546 99.9 µM -1.05894273985404 0.132668465494003 no 2937 0.144812929006862 4195 702008 SGTC_1618 st003135 44.5 µM -1.05977886573611 0.132497378256241 no 2938 0.144622606889064 4112 1270615 SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM -1.06033243084164 0.132384191997337 no 2939 0.144496695065368 4078 1241132 A phosphatase inhibitor. SGTC_2644 guaiazulene 100 µM -1.06183632499586 0.132077030510116 no 2940 0.144154997998216 4161 3515 A coloring agent. SGTC_253 dyclonine 31.25 µM -1.06255759137718 0.131929890620239 no 2941 0.143991313822956 4248 3180 An oral anasthetic. SGTC_1972 st070201 17.4 µM -1.06479269476048 0.131474642966128 no 2942 0.143484875851248 4162 2829099 SGTC_2042 p-Dimethylaminoacetophenone 200 µM -1.06525185765167 0.131381254733802 no 2943 0.143380986097846 4165 75037 A free radical scavenger. SGTC_915 methyl methanesulfonate (MMS) 110 mM -1.06614819691214 0.131199082061348 no 2944 0.14317832762195 4208 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks. SGTC_2321 7390090 138.78 µM -1.06671920901305 0.131083120142453 no 2945 0.143049325165148 4201 649046 SGTC_574 1315-0397 40 µM -1.06741406996324 0.130942102362112 no 2946 0.142892448861977 4130 6794277 SGTC_2379 9035213 200 µM -1.06829035721352 0.130764414729475 no 2947 0.142694778413044 4169 646551 SGTC_2939 9044578 71.43 µM -1.06961912386137 0.130495294473276 no 2948 0.142395391782399 4098 2653634 SGTC_1087 pterostilbene 9.05 µM -1.07178172898932 0.130058113151158 no 2949 0.141909040753214 4207 5281727 Similar to reservatol, lowers cholesterol. SGTC_2403 6032726 181.2 µM -1.07289884018778 0.129832681102716 no 2950 0.141658253250777 4225 2881040 SGTC_1259 0671-0132 43 µM -1.07296400413226 0.129819539433081 no 2951 0.141643633449441 4090 X1259 SGTC_2553 4-methylesculetin 85.09 µM -1.07301519077338 0.129809217224359 no 2952 0.141632150230913 4193 5319502 SGTC_343 4130-2827 29.8 µM -1.07338338539934 0.129734984485343 no 2953 0.141549567979383 4183 1118244 SGTC_2113 5491891 107.031 µM -1.07379954455198 0.129651116883826 no 2954 0.141456267064221 4170 789979 SGTC_1897 st060201 15 µM -1.07489134620891 0.129431267114719 no 2955 0.141211688419276 4206 611878 SGTC_137 0438-0332 85.389 µM -1.07664861238816 0.129077959342866 no 2956 0.140818638927973 4122 2063393 YER012W | YPR107C PRE1 | YTH1 SGTC_1799 st045822 46.1415 µM -1.07671925356396 0.129063770550812 no 2957 0.140802854079506 4145 3674992 SGTC_2014 4013930 200 µM -1.07691237108191 0.12902498701748 no 2958 0.140759707884842 4137 64556 SGTC_450 aminopyrene 156 nM -1.07784690615399 0.128837419770674 no 2959 0.140551041405167 4102 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1 SGTC_790 1575-0012 79.1 µM -1.07902857272051 0.128600522530293 no 2960 0.140287495237262 4225 378741 YLR208W SEC13 SGTC_1568 digitonin 820 nM -1.07910454224698 0.12858530271848 no 2961 0.140270563302977 4179 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1 SGTC_1258 0671-0043 57.1 µM -1.07946230205944 0.128513645560468 no 2962 0.140190845179087 4195 4298767 SGTC_2263 7948595 193.29 µM -1.08001825668358 0.128402346172827 no 2963 0.140067025214368 4164 2971371 SGTC_3356 9151811 4.48 µM -1.08197762430382 0.128010623970282 no 2964 0.139631235300843 4184 1859254 YPR165W RHO1 SGTC_3202 9113761 49.47 µM -1.08264146317201 0.127878095948496 no 2965 0.139483797861264 4164 4798415 SGTC_642 0335-0876 158 µM -1.08451551202494 0.127504477612686 no 2966 0.139068146492043 4207 6812350 SGTC_1404 3909-7820 48.3 µM -1.088724498995 0.126668124799232 no 2967 0.138137697408565 4156 23741373 SGTC_2965 9082772 38.63 µM -1.08941059578481 0.126532155924854 no 2968 0.137986430464148 4187 16459634 SGTC_1194 1488-0194 225 µM -1.0899686384992 0.126421639474735 no 2969 0.137863479544692 4130 1391452 SGTC_1675 st018485 24.5 µM -1.09686581629405 0.125061252573011 no 2970 0.136350026914912 4224 3323024 SGTC_685 1278-0033 54.9 µM -1.09982771807621 0.124480201878045 no 2971 0.135703596494929 4266 3590572 SGTC_2028 5153890 36.43 µM -1.10121141121656 0.124209403920075 no 2972 0.13540232819797 4172 2830968 YPR165W RHO1 SGTC_992 3909-8734 162 µM -1.10372664225444 0.123718212418393 no 2973 0.134855867445757 4215 4288319 SGTC_551 k048-0028 34.9 µM -1.10561976317121 0.123349408973868 no 2974 0.134445566016781 4189 6836383 SGTC_743 1275-0778 158 µM -1.1064939985816 0.123179357306112 no 2975 0.134256380094045 4184 2849257 YMR203W TOM40 SGTC_39 0986-0283 58.349 µM -1.10696813391365 0.123087199745809 no 2976 0.134153852965325 4279 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2 SGTC_570 0987-0065 62.6 µM -1.10836346064271 0.122816270884977 no 2977 0.133852439305267 3982 3104428 SGTC_3189 9110682 49.47 µM -1.10997189313062 0.122504482768967 no 2978 0.133505569191625 4266 17122418 SGTC_2994 9053520 71.4286 µM -1.11093283041651 0.122318474216201 no 2979 0.133298631363795 4249 4647384 SGTC_1604 st002052 72.4 µM -1.11129248151239 0.122248907592002 no 2980 0.13322123729212 4285 6254834 YHR062C RPP1 SGTC_2491 paeonol 100 µM -1.11269601465166 0.121977690568323 no 2981 0.132919503878938 4137 11092 Increases levels of cortical cytochrome oxidase. SGTC_1964 st076914 61 µM -1.11298651512903 0.121921607440652 no 2982 0.132857110519729 4245 24208661 SGTC_2382 9035899 200 µM -1.11412004334519 0.121702945206639 no 2983 0.132613845518448 4203 6462679 SGTC_666 0272-0154 136 µM -1.11541258129912 0.121453945784944 no 2984 0.132336830287833 4213 6870312 SGTC_3180 9109287 49.47 µM -1.11661011087945 0.121223568957556 no 2985 0.132080533307925 4258 18891271 SGTC_2790 5423970 71.43 µM -1.12023840557242 0.120527446280473 no 2986 0.131306090952451 4271 1376240 YKL165C | YIL048W MCD4 | NEO1 SGTC_1736 st036774 51 µM -1.12054115312236 0.120469488797084 no 2987 0.131241612949337 4260 1272247 SGTC_357 1325-0123 420 µM -1.12148273500201 0.120289359398835 no 2988 0.131041218254003 4225 1098503 SGTC_110 0850-0284 111.64 µM -1.12160602366555 0.120265787707108 no 2989 0.131014994673284 4016 3906265 SGTC_3195 9113082 49.47 µM -1.12358086384391 0.11988865937658 no 2990 0.130595438995689 4208 17018038 SGTC_1029 k015-0030 64.7 µM -1.12698677126961 0.119240205504655 no 2991 0.129874037067328 4266 2208316 SGTC_2309 7664088 163.95 µM -1.12853138720802 0.11894694201934 no 2992 0.12954778450963 4233 704922 SGTC_2199 6590217 200 µM -1.1295367986398 0.118756326729063 no 2993 0.129335727615238 4110 703109 SGTC_2514 salinomycin 42.74 µM -1.13007723658559 0.118653954672472 no 2994 0.129221840317479 4273 23682228 A polyether potassium ionophore. SGTC_2445 5742597 35.57 µM -1.13104392077084 0.118470996782029 no 2995 0.12901830292875 4203 1774255 SGTC_1491 4138-0063 26.5 µM -1.13136156196847 0.118410922489614 no 2996 0.128951471458353 4190 23883227 SGTC_669 0108-0021 26.2 µM -1.13323467888861 0.11805710475895 no 2997 0.128557857307948 4165 17201 SGTC_2601 securinine 100 µM -1.13325045141237 0.118054128625839 no 2998 0.128554546436159 4200 442872 A GABA receptor antagonist. SGTC_1796 st049173 110.4 µM -1.13625627443714 0.117487925301144 no 2999 0.127924662438119 4186 94134 SGTC_81 0411-0046 9.971 µM -1.13766840580288 0.117222588660531 no 3000 0.127629485413847 4174 12925265 SGTC_1793 st048256 72.231 µM -1.13862827959044 0.117042472810218 no 3001 0.127429114051272 4149 672022 SGTC_3118 9124250 49.47 µM -1.13968447017411 0.116844510269304 no 3002 0.127208889705041 4165 1504786 SGTC_2768 sulfasalazine 50.2 µM -1.13972257604023 0.116837372498742 no 3003 0.127200949273346 4209 5384001 An antioxidant and salicylic acid derivative. SGTC_3350 9150499 3.57 µM -1.14172168056408 0.116463345149003 no 3004 0.126784862989786 4236 4910996 YPR165W RHO1 SGTC_695 3505-6186 243 µM -1.14507249985623 0.115838321782428 no 3005 0.126089563052175 4229 1819379 SGTC_2463 5473429 200 µM -1.14968071802066 0.114982653564171 no 3006 0.125137699448179 4228 5399405 SGTC_730 1436-0052 41.2 µM -1.15003255926304 0.114917507788838 no 3007 0.125065230629539 4272 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2 SGTC_2057 5236571 38.335 µM -1.15194271834419 0.114564287126784 no 3008 0.124672306299081 4221 54684039 YBR257W POP4 SGTC_812 4251-0442 148 µM -1.15292658518666 0.114382655340293 no 3009 0.12447025952369 4268 5723007 SGTC_2640 pentamidine 10.38 µM -1.15503024018495 0.113994987353342 no 3010 0.124039021573791 4230 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_2292 7671323 168.05 µM -1.15513820855938 0.113975115895995 no 3011 0.124016916878575 4303 937504 SGTC_762 1165-0429 115 µM -1.15748518560689 0.113543767205937 no 3012 0.123537094212457 4260 5967793 SGTC_1201 1889-3372 45.9 µM -1.15967772435147 0.113141855368859 no 3013 0.123090021416003 4119 5392199 SGTC_1521 st012942 49.4 µM -1.16011738328429 0.113061384315288 no 3014 0.123000508800065 4212 24207259 SGTC_713 1488-1073 324 µM -1.1741864159672 0.110507853919668 no 3015 0.120160182913649 4264 3312542 SGTC_2556 citropten 84.59 µM -1.17423582028872 0.110498960480002 no 3016 0.120150291040831 4293 2775 A potential DNA crosslinker. SGTC_446 go6976 132 µM -1.17432255397685 0.110483348495411 no 3017 0.120132926364788 4287 3501 A protein kinase C inhibitor. SGTC_458 nppb 133 µM -1.17659638056228 0.110074625786774 no 3018 0.119678321559774 4313 4549 A chloride channel blocker. SGTC_1144 3486-0183 12.5 µM -1.1788310867028 0.10967399305691 no 3019 0.119232721534299 4261 6744069 SGTC_844 0330-0132 15.3 µM -1.18047172359239 0.109380530772068 no 3020 0.118906325137235 4306 2828079 SGTC_156 3474-0145 5.642 µM -1.18193062824872 0.109120049253185 no 3021 0.118616613929738 4137 2265471 SGTC_2054 5233173 129 µM -1.18334410348162 0.108868104434432 no 3022 0.118336400213145 4295 6889 SGTC_564 3555-0129 330 µM -1.18375254594207 0.108795379576351 no 3023 0.118255515956716 4149 563260 SGTC_1703 st026983 48.3 µM -1.18504300550727 0.108565837495587 no 3024 0.118000221876817 4298 1104023 SGTC_1368 1852-0141 284 µM -1.19230287099637 0.107280971460802 no 3025 0.116571254602513 4283 2838987 SGTC_1162 k048-0130 20.1 µM -1.19882643778388 0.106135800811029 no 3026 0.115297720127168 4240 6797406 SGTC_1334 1486-0610 236 µM -1.20286865349487 0.105430661581332 no 3027 0.114513576173604 4349 3742339 SGTC_1606 st000094 49.2 µM -1.20784354850384 0.104567481790578 no 3028 0.113553723493598 4317 1242210 SGTC_2766 oltipraz 83.91 µM -1.21019634343443 0.104161042901237 no 3029 0.11310178043695 4267 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40 SGTC_1277 0873-0036 22 µM -1.21681724432631 0.103023448911454 no 3030 0.111836878741974 4370 5965735 SGTC_2659 sanguinarine 24.21 µM -1.21982185860961 0.102510187843978 no 3031 0.111266206598812 4239 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis. SGTC_1132 3456-3614 2.5 µM -1.22011952020742 0.102459441406028 no 3032 0.111209784861898 4335 3125502 SGTC_3160 9100216 49.47 µM -1.22041396117362 0.10240926200594 no 3033 0.11115399375188 4263 17191039 SGTC_1697 st025554 27.742 µM -1.22636463737738 0.101398959495289 no 3034 0.110030743636582 4304 1269519 SGTC_227 fluconazole 33.516 µM -1.23098654682067 0.100619278386981 no 3035 0.109163947976159 4307 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C SGTC_1954 st077032 68.9 µM -1.23148726230276 0.100535074742308 no 3036 0.109070338899245 4264 698907 SGTC_2479 5617353 43.85 µM -1.23185361056446 0.10047349975732 no 3037 0.109001886414352 4333 2731746 SGTC_1714 st033236 13.627 µM -1.23282964577712 0.100309584294686 no 3038 0.108819664144034 4346 2916566 SGTC_116 0155-0182 31.788 µM -1.23961963925099 0.0991746710271158 no 3039 0.107558056546723 4198 771486 SGTC_29 0299-0004 12.984 µM -1.24174288308244 0.0988217160976214 no 3040 0.107165721227779 4205 16871 A napthoquinone isolated from Swertia calycina. SGTC_1241 0364-0022 50.8 µM -1.24372534176164 0.0984929950025698 no 3041 0.106800332925717 4313 4563895 SGTC_2384 9036245 200 µM -1.24923882455435 0.097582988403156 no 3042 0.105788867813808 4253 6462766 SGTC_2891 9063876 19.48 µM -1.2498987682983 0.0974744784674509 no 3043 0.105668264714451 4348 6472478 SGTC_1397 3532-0190 20.1 µM -1.25091135623379 0.0973081578245842 no 3044 0.105483410085623 4264 5322280 SGTC_3152 9099253 49.47 µM -1.25462187727503 0.0967004728820258 no 3045 0.104808028877961 4213 25236131 SGTC_2117 5521686 200 µM -1.25480323035544 0.0966708436610121 no 3046 0.104775099818875 4303 803312 SGTC_2887 9044784 58.44 µM -1.25568142351542 0.0965274599724111 no 3047 0.104615748486038 4291 6465546 SGTC_2716 st080858 38.6235 µM -1.25869543960043 0.0960365461733929 no 3048 0.104070179628152 4303 5296050 SGTC_2205 7238770 200 µM -1.25940666393376 0.095920972289528 no 3049 0.103941741845968 4394 279867 SGTC_1193 1488-0126 41.5 µM -1.26082031370708 0.0956915581191227 no 3050 0.10368679663985 4301 1384710 SGTC_3058 9093861 49.47 µM -1.26168541398759 0.0955513645703166 no 3051 0.103531003745735 4359 17217477 SGTC_3188 9110789 49.47 µM -1.26682927651331 0.094720897833201 no 3052 0.102608170687647 4321 849217 SGTC_2797 7859098 81.82 µM -1.27221352905892 0.0938573316286882 no 3053 0.101648630991293 4324 972681 SGTC_692 k241-0027 77.8 µM -1.27358703260446 0.0936379721556851 no 3054 0.101404905138379 4383 3600480 SGTC_2255 7941087 197.44 µM -1.2747044493429 0.0934597912349501 no 3055 0.101206935707092 4451 935561 SGTC_991 3996-0057 64.7 µM -1.27471636383898 0.0934578927247767 no 3056 0.101204826369475 4385 715343 SGTC_2221 6807166 181.081 µM -1.27594733908862 0.0932618969829096 no 3057 0.100987067605945 4310 674925 SGTC_1435 4092-0789 56.7 µM -1.27704378905529 0.0930875762171197 no 3058 0.100793394063141 4335 2248285 SGTC_2902 5787006 60.46 µM -1.27867991892747 0.0928279015871823 no 3059 0.100504896979722 4300 591003 SGTC_3293 9120939 62.045 µM -1.28076247893089 0.0924981481066044 no 3060 0.100138553414704 4338 934087 SGTC_589 1227-0070 34.1 µM -1.28441615706665 0.0919217184194291 no 3061 0.0994981913171024 4404 2841384 SGTC_1312 1218-2183 165 µM -1.28756495081455 0.0914270807845164 no 3062 0.0989487232795272 4411 6744073 SGTC_226 1,3-diallylurea 8.28947 mM -1.28846461101945 0.0912861180164609 no 3063 0.098792140064667 4286 74537 YKL182W FAS1 SGTC_2982 9019404 25.97 µM -1.28939619276715 0.0911403235196666 no 3064 0.0986301921699976 4292 22333232 SGTC_3213 9129884 49.47 µM -1.29361908664474 0.0904815969006455 no 3065 0.0978985131676367 4338 17190742 SGTC_1335 1486-0900 202 µM -1.30147708748177 0.0892652519509361 no 3066 0.0965476011483553 4361 X1335 SGTC_700 3453-2283 142 µM -1.30178352037507 0.0892180666780214 no 3067 0.0964951994222518 4399 565664 SGTC_2793 7325131 81.82 µM -1.30458132501805 0.0887881119737045 no 3068 0.0960177253718761 4304 4176441 SGTC_958 1222-0007 33 µM -1.30496836657041 0.0887287547664523 no 3069 0.0959518097920482 4428 7312461 SGTC_1743 st037606 46.3785 µM -1.30737253818714 0.0883607095697454 no 3070 0.0955431096686037 4326 590142 YLR208W | YDL195W SEC13 | SEC31 SGTC_876 0720-0963 56.8 µM -1.31104458905891 0.087800767269547 no 3071 0.0949213498079723 4404 765861 SGTC_36 0335-0881 14.2 µM -1.31166867638789 0.0877058654042836 no 3072 0.0948159749911216 4281 23828853 SGTC_3278 9139605 49.47 µM -1.3118245070224 0.0876821809565657 no 3073 0.0947896770237929 4362 7958859 SGTC_3007 9078383 71.4286 µM -1.31846887448834 0.0866767481861137 no 3074 0.0936733689273321 4374 6496995 SGTC_114 0364-0001 490.298 µM -1.31937117787108 0.0865408778861874 no 3075 0.0935225262710508 4411 4003655 SGTC_1715 st032160 10.2275 µM -1.32269137924182 0.0860422873238956 no 3076 0.0929690157813814 4306 5289825 SGTC_27 0485-0001 32.618 µM -1.3236131730956 0.0859042445906841 no 3077 0.0928157739711138 4376 2054479 SGTC_435 c-PAF 6.7 µM -1.32834756331096 0.0851978593389759 no 3078 0.0920316568319196 4336 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase SGTC_490 phenamil 164 µM -1.33534736303317 0.0841614554609908 no 3079 0.0908813419082783 4398 4755 Irreversibly blocks amiloride-sensitive Na+ channels. SGTC_1942 st076330 65.2 µM -1.33794936362288 0.0837786205980908 no 3080 0.0904564719460761 4443 24208414 SGTC_22 0964-0034 14.468 µM -1.34117216172902 0.0833062624591436 no 3081 0.0899322812560389 4401 138402 SGTC_2121 5257820 149.641 µM -1.34558318956175 0.0826629974107868 no 3082 0.0892184880168997 4430 791256 SGTC_2064 5220758 200 µM -1.34600124105553 0.0826022269705217 no 3083 0.0891510581704804 4432 788518 SGTC_381 3461-2219 42.7 µM -1.34782030494363 0.0823381885291865 no 3084 0.0888580927555155 4388 2883159 SGTC_3298 9116858 71.43 µM -1.34999353306279 0.0820235767009751 no 3085 0.0885090286308366 4464 2506942 SGTC_2966 9084041 48.03 µM -1.3504192543419 0.0819620525176088 no 3086 0.0884407690585201 4314 17741380 SGTC_829 1635-0120 117 µM -1.35172524520839 0.0817735309177711 no 3087 0.0882316129864263 4409 285054 SGTC_2796 7949634 45.45 µM -1.35220691506939 0.0817040837673935 no 3088 0.088154566090262 4367 2971588 SGTC_199 4063-0024 41.6 µM -1.35689344069497 0.081030699833565 no 3089 0.0874075356601783 4439 306215 SGTC_1343 1487-0095 224 µM -1.36349364744708 0.0800894633764061 no 3090 0.0863634925876523 4412 4560101 YGL055W OLE1 SGTC_1453 4237-0541 195 µM -1.36417428814956 0.079992871243489 no 3091 0.0862563592182143 4408 739892 SGTC_2164 5685496 200 µM -1.36422127512832 0.0799862064065208 no 3092 0.0862489671010183 4330 759046 SGTC_2687 chenodiol 100 µM -1.36705431778092 0.0795851307338408 no 3093 0.0858041402908163 4449 5702181 A cholesterol synthesis inhibitor. SGTC_3263 9137018 49.47 µM -1.36899865481921 0.0793107514834769 no 3094 0.0854998476982531 4364 43844957 SGTC_1758 st042942 75.2445 µM -1.3711046371342 0.0790143698287026 no 3095 0.0851711698232588 4384 669317 SGTC_2876 9059903 25.97 µM -1.37188378080825 0.0789049312789316 no 3096 0.0850498101346396 4404 6916095 SGTC_567 1080-0542 68.4 µM -1.37203698270977 0.0788834260492168 no 3097 0.0850259626083525 4304 5950415 SGTC_2519 cryptotanshinone 88.04 µM -1.37422308307464 0.0785770427023556 no 3098 0.084686218341 4407 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE) SGTC_694 1315-0438 43.2 µM -1.37613211715224 0.0783102288573667 no 3099 0.0843903668642178 4432 6793154 SGTC_1088 bifonazole 369 nM -1.37679544612522 0.0782176804948776 no 3100 0.0842877495915907 4406 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase. SGTC_204 PMA1.184 62.41 µM -1.3781985550056 0.0780221906038945 no 3101 0.0840709966407436 4385 2252213 YGL008C PMA1 SGTC_2910 7948405 25.97 µM -1.37914382332226 0.0778906990563542 no 3102 0.083925207228792 4375 2971328 SGTC_266 formosanin C 406 nM -1.38309972294792 0.0773422376688273 no 3103 0.0833171453189694 4272 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1 SGTC_210 3551-0445 56.827 µM -1.38496390888702 0.0770847987813898 no 3104 0.0830317517108329 4426 2865180 YOR207C RET1 SGTC_2685 mycophenolic acid 18.85 µM -1.38543461292363 0.0770198989512556 no 3105 0.0829598066701845 4426 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_56 0957-0365 83.25 µM -1.39213673395438 0.0761003222193643 no 3106 0.0819404981972407 4379 6752360 SGTC_111 0083-0039 52.457 µM -1.3929941457129 0.0759832850389107 no 3107 0.0818107805023124 4382 759313 SGTC_705 1124-0212 310 µM -1.39433500707491 0.075800531534168 no 3108 0.081608232166073 4416 9554485 SGTC_1586 deoxycorticosterone acetate 53.7 µM -1.39475538819938 0.0757433044238462 no 3109 0.0815448079935636 4440 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE. SGTC_2898 9056270 58.44 µM -1.39720038997122 0.0754111148225362 no 3110 0.0811766597487212 4441 19154699 SGTC_1370 2001-0092 44.6 µM -1.39868938644529 0.075209357367698 no 3111 0.0809530741652848 4435 790957 SGTC_1115 galangin 695.678 nM -1.39946976485912 0.0751037814134861 no 3112 0.0808360794682177 4512 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_2991 9074669 71.4286 µM -1.40231667508854 0.0747195862258012 no 3113 0.0804103515553201 4395 17333109 SGTC_1410 3909-8106 77.9 µM -1.41006197764349 0.0736819356109449 no 3114 0.0792606915666319 4504 1039210 SGTC_2431 5490079 200 µM -1.41231239811886 0.0733825180534839 no 3115 0.078928998715977 4478 5722345 SGTC_1380 2291-0730 164 µM -1.41401782667695 0.0731562319870169 no 3116 0.0786783341933185 4434 2999191 SGTC_1903 st060211 78.3 µM -1.41524356615198 0.072993923878748 no 3117 0.078498547498429 4458 688960 SGTC_2582 agaric acid 100 µM -1.42033508097397 0.0723226723735235 no 3118 0.0777550763592721 4039 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase. SGTC_1327 1436-0082 2.18 µM -1.42361308703273 0.0718930184309187 no 3119 0.0772792526703477 4465 15992205 SGTC_2329 6138490 200 µM -1.42385809171263 0.0718609840270217 no 3120 0.0772437777042587 4489 720019 SGTC_1730 st033808 45.1 µM -1.42480030207065 0.0717378918496948 no 3121 0.0771074674956574 4374 1045166 SGTC_3290 9121031 71.43 µM -1.4267630097342 0.0714819993641325 no 3122 0.0768241083306416 4464 17014854 SGTC_1490 4089-0339 670 nM -1.43066574809515 0.0709752529040028 no 3123 0.0762630171251715 4433 742542 SGTC_2125 5246583 200 µM -1.43266500664048 0.0707167325987804 no 3124 0.0759767972159547 4452 835267 SGTC_159 3970-0959 50 µM -1.43419656485533 0.0705191796741002 no 3125 0.075758088539814 4486 6615653 SGTC_3194 9111903 49.47 µM -1.44025203084686 0.0697422485397604 no 3126 0.0748980537286305 4460 17087251 SGTC_3237 9133362 49.47 µM -1.44078330638003 0.069674400221185 no 3127 0.0748229555215907 4424 43845137 SGTC_140 0062-0056 502.533 µM -1.44412538874413 0.0692487530830577 no 3128 0.074351853794707 4364 3758964 SGTC_2867 9039098 71.43 µM -1.44547386969838 0.0690775790504952 no 3129 0.0741624137507541 4436 6463460 SGTC_2639 lactacystin 53 µM -1.45376225105729 0.068032617804579 no 3130 0.0730061162893044 4487 3870 A proteasome inhibitor. SGTC_507 nimesulide 162 µM -1.45706543998867 0.0676195841634058 no 3131 0.0725491585703156 4505 4495 A COX2 inhibitor. SGTC_1508 1080-0625 72.9 µM -1.46191304809867 0.0670169463405127 no 3132 0.0718825194598816 4400 767111 SGTC_2131 toluylene red 5.2905 µM -1.46575220439406 0.066542630146402 no 3133 0.0713579031817836 4428 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain. SGTC_2980 9014342 25.29 µM -1.4710511101138 0.0658922400146963 no 3134 0.0706386476336273 4510 2996599 SGTC_1644 st010134 20.9 µM -1.47195017264826 0.065782379165968 no 3135 0.0705171667359909 4458 3818134 SGTC_278 4092-0821 23.9 µM -1.47493634150546 0.0654185033238557 no 3136 0.0701148293874788 4477 877900 SGTC_2426 5582046 32.21 µM -1.47658435933853 0.0652183557932652 no 3137 0.0698935434222017 4470 2251934 SGTC_1281 0884-0031 11.8 µM -1.48477087279827 0.0642311591869342 no 3138 0.0688022650851025 4492 1548255 SGTC_2518 prenyletin 46.28 µM -1.48635934647745 0.0640409605116442 no 3139 0.0685920484425492 4505 3873459 A coumarin with calcium channel inhibitory activity. SGTC_3039 9090270 49.47 µM -1.48714171407868 0.0639474434524741 no 3140 0.0684886931353595 4497 17173750 SGTC_1969 st069479 40.1 µM -1.49696623408127 0.0627821302659974 no 3141 0.0672010221236477 4485 3895485 SGTC_1210 3013-0140 750 nM -1.50324913465441 0.062045616979886 no 3142 0.066387405710118 4512 905973 SGTC_3210 9128157 49.47 µM -1.50842848619187 0.061443551435462 no 3143 0.0657224484529257 4439 17590849 SGTC_2345 9052315 157.45 µM -1.50910630665748 0.0613650980975613 no 3144 0.0656358090755902 4494 6469265 SGTC_86 0417-1630 471.922 µM -1.50976402146308 0.06128904668899 no 3145 0.065551824291234 4480 3634867 SGTC_2515 chrysin 20.77 µM -1.51245856765763 0.060978245548133 no 3146 0.0652086226107767 4511 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor. SGTC_2076 5212012 200 µM -1.51321792704341 0.0608908805116445 no 3147 0.0651121560063037 4484 604802 SGTC_1695 st026914 34.495 µM -1.51409051814304 0.0607906089345556 no 3148 0.0650014415948755 4489 3289191 SGTC_223 busulfan 5 mM -1.51577649024704 0.0605972355740985 no 3149 0.0647879393276657 4498 2478 A DNA alkylator. SGTC_311 1315-0136 58 µM -1.51934069834426 0.0601900211825761 no 3150 0.0643383802439438 4533 6759207 SGTC_2000 st075254 36.4 µM -1.52194591974485 0.0598937295502566 no 3151 0.0640113159587236 4389 17234175 SGTC_2438 5259590 200 µM -1.52260136536598 0.0598193659272653 no 3152 0.0639292339945701 4515 1201127 SGTC_780 0109-0199 192 µM -1.52512321604981 0.0595339235106342 no 3153 0.0636141837962295 4538 610414 SGTC_2361 9034121 116 µM -1.52920657804322 0.0590740022475366 no 3154 0.0631066201943095 4530 6496917 SGTC_1340 1486-1359 257 µM -1.53352364224755 0.0585907941322242 no 3155 0.0625734429931323 4461 4309068 SGTC_2389 9091542 195.52 µM -1.54037701859386 0.0578300767526048 no 3156 0.0617342399521958 4477 3626624 YOL127W RPL25 SGTC_525 k781-2675 26.7 µM -1.54321206779537 0.057517668802548 no 3157 0.061389665118026 4460 3651118 YDL195W SEC31 SGTC_2837 9008476 45.46 µM -1.54762981732922 0.0570335032085039 no 3158 0.0608557241206347 4481 2992805 SGTC_1551 6-bromo-3'-methylflavone 63.5 µM -1.54846604948045 0.056942218103747 no 3159 0.0607550648180577 4516 688751 SGTC_3086 9117350 49.47 µM -1.54853697244455 0.0569344812785672 no 3160 0.0607465336415519 4498 2679265 SGTC_2561 acetosyringone 100 µM -1.55061014089419 0.056708689568238 no 3161 0.060497570220575 4468 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent. SGTC_2647 atorvastatin 60.16 µM -1.55432118257172 0.056306276808923 no 3162 0.0600539116185305 4499 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7 SGTC_2184 6075246 200 µM -1.55673939272501 0.0560452679710453 no 3163 0.0597661859419773 4510 2267320 SGTC_1455 4262-0120 131 µM -1.55866107706541 0.0558385327357156 no 3164 0.059538309396191 4564 1529587 SGTC_2953 9074162 66.49 µM -1.55964917666562 0.0557324672266649 no 3165 0.059421404275355 4506 16451992 SGTC_1509 1326-1131 80 µM -1.56155197297516 0.0555286634188584 no 3166 0.0591967855453933 4518 768313 SGTC_828 2074-0507 139 µM -1.56322419785613 0.0553500416731523 no 3167 0.0589999352234701 4568 X828 SGTC_3162 9099653 49.47 µM -1.56343163531465 0.0553279155325516 no 3168 0.0589755520258847 4504 25237511 SGTC_2847 9005661 71.43 µM -1.56403882552584 0.0552631902477502 no 3169 0.0589042254024251 4567 2991449 SGTC_3235 9132602 49.47 µM -1.56636674283902 0.0550155928304013 no 3170 0.0586313920423401 4508 4912240 SGTC_2080 5212524 12.4 µM -1.5667767595786 0.0549720743539187 no 3171 0.0585834407411072 4483 260183 SGTC_863 0466-0191 129 µM -1.57184612675867 0.0544362648035935 no 3172 0.0579931205405693 4576 765160 YPR165W RHO1 SGTC_1188 1403-0014 4.57 µM -1.57199709948973 0.0544203712285949 no 3173 0.0579756119452624 4553 9614867 SGTC_53 0973-0023 39.979 µM -1.57348070970536 0.0542643801424644 no 3174 0.0578037757788161 4444 674768 SGTC_2462 5162487 171.77 µM -1.57570743281574 0.054030920225282 no 3175 0.0575466218489962 4499 2259986 SGTC_473 2-arachidonoylglycerol 10 µM -1.57958615460834 0.0536261565003233 no 3176 0.0571008360163851 4388 5282280 An endocannabinoid. SGTC_1854 st056233 32.9 µM -1.57965450157752 0.0536190457523487 no 3177 0.0570930052647785 4469 5393174 SGTC_2841 9004761 38.96 µM -1.5804683274527 0.0535344335343275 no 3178 0.0569998273337745 4479 2991039 SGTC_2374 9071832 200 µM -1.58201104335253 0.0533743301071364 no 3179 0.0568235247301066 4475 17381698 SGTC_2873 9040596 71.43 µM -1.58308319122112 0.0532632860142097 no 3180 0.0567012521129244 4502 6463863 SGTC_2806 7952793 58.44 µM -1.59411278862486 0.0521315359004176 no 3181 0.0554553875268965 4557 2972490 SGTC_1119 parthenolide 318.541 nM -1.59499347815482 0.0520419979048224 no 3182 0.055356847106193 4578 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs. SGTC_2740 felodipine 17.08 µM -1.59638114684442 0.0519011642804262 no 3183 0.0552018613824891 4602 3333 L-type calcium channel blocker SGTC_3182 9108849 49.47 µM -1.6003727861624 0.0514977433581615 no 3184 0.0547579542774659 4551 17133045 SGTC_2158 5657123 3.6195 µM -1.60040877117506 0.0514941178538606 no 3185 0.0547539652850106 4548 2858827 SGTC_1024 4507-0395 26 µM -1.60205325476112 0.0513286519570844 no 3186 0.0545719168188819 4574 4201836 SGTC_1927 st060202 13.8 µM -1.60417831863816 0.051115457393319 no 3187 0.0543373761994414 4479 688887 SGTC_938 3126-1755 342 µM -1.6057829138219 0.0509549456507481 no 3188 0.0541608080304457 4536 1777771 SGTC_2808 7946468 45.46 µM -1.6132127724604 0.0502169414663359 no 3189 0.0533491447431901 4526 2970879 SGTC_323 4013-0906 34.3 µM -1.6135010370843 0.0501884808902256 no 3190 0.053317849061823 4581 2910086 SGTC_2986 9022445 71.43 µM -1.61654834231946 0.0498884040112521 no 3191 0.0529879051537393 4519 6459286 SGTC_914 3820-6779 408 µM -1.61659771609258 0.0498835538409428 no 3192 0.0529825726191264 4478 2893481 SGTC_697 0508-1955 564 µM -1.61690427239446 0.0498534480856769 no 3193 0.0529494730251466 4565 6243113 SGTC_1221 2958-7315 257 µM -1.62858522131078 0.0487170632232187 no 3194 0.0517004274590557 4585 4562705 SGTC_1636 st007707 68.9 µM -1.63032201270935 0.0485498811131074 no 3195 0.0515167287810118 4567 403051 SGTC_2130 NSC 7 2.4545 µM -1.63087289122238 0.0484969499293829 no 3196 0.0514585714603987 4599 21448 SGTC_365 0121-0052 13.6 µM -1.63546464291935 0.0480575446021031 no 3197 0.0509758404017484 4542 3101739 SGTC_1892 st058411 7.36 µM -1.63672597566562 0.0479374014718031 no 3198 0.0508438694516332 4558 3934738 SGTC_506 n9-isopropylolomoucine 153 µM -1.63912395738878 0.0477096545726873 no 3199 0.0505937232669105 4576 6610355 SGTC_1369 1866-0067 208 µM -1.6475963843612 0.0469119220053309 no 3200 0.0497177614415018 4575 3531355 SGTC_2746 daunorubicin 9.88 µM -1.65867193895428 0.0458852604310782 no 3201 0.048590958422616 4601 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_2448 5185112 27.17 µM -1.66049476518133 0.0457180347129106 no 3202 0.0484074800672649 4573 5718189 SGTC_682 0kpi-0099 17 µM -1.66097492923655 0.0456740661698511 no 3203 0.0483592410010809 4570 1714895 YML126C ERG13 SGTC_2412 st077135 33.4 µM -1.66188107452656 0.0455911832034384 no 3204 0.0482683110281781 4578 13258915 SGTC_1554 st069299 38.7 µM -1.66220029180699 0.0455620139730512 no 3205 0.0482363107735842 4528 24207999 SGTC_184 1494-0393 24.714 µM -1.6646193322937 0.0453414558664162 no 3206 0.0479943629631262 4560 3090647 SGTC_1520 flindersine 88 µM -1.66522228470119 0.0452866150803823 no 3207 0.0479342082911346 4579 68230 Flindersine is a natural alkaloid of the quinoline subtype. SGTC_2816 7982706 58.44 µM -1.67442263767471 0.0444564090728036 no 3208 0.0470237834244281 4555 2981853 SGTC_797 k781-0471 270 µM -1.67545087874472 0.0443643911483331 no 3209 0.0469229005790582 4545 23738129 SGTC_891 0929-0073 133 µM -1.67658246131892 0.044263302593878 no 3210 0.0468120793821058 4591 5603632 SGTC_842 0271-0008 11.1 µM -1.67881281023052 0.0440646006998558 no 3211 0.0465942656017478 4590 1221709 SGTC_1909 st060837 51.5 µM -1.67939989386551 0.0440124171397719 no 3212 0.0465370669852753 4522 678937 SGTC_1183 1254-0324 198 µM -1.68025316280318 0.0439366622733355 no 3213 0.0464540348486006 4616 5799357 SGTC_152 4469-0003 551.229 µM -1.683569435139 0.0436432352600085 no 3214 0.0461324549160035 4556 697280 SGTC_777 1315-0167 517 µM -1.68563714022574 0.0434610844501581 no 3215 0.0459328555288972 4602 4221767 SGTC_2350 9023895 38.85 µM -1.68794411585863 0.0432585803668621 no 3216 0.0457109785097797 4548 2997209 SGTC_738 1315-0003 72.4 µM -1.68837922921215 0.0432204720822734 no 3217 0.0456692275205546 4589 6251474 SGTC_3215 9129942 49.47 µM -1.69657078559723 0.0425080823183148 no 3218 0.0448889184793402 4551 17682944 SGTC_1643 st009866 20.2 µM -1.69660950520126 0.0425047377027206 no 3219 0.0448852557871717 4575 3156273 YOR207C RET1 SGTC_2331 7980721 200 µM -1.70613693837985 0.0416882008502993 no 3220 0.0439912932835973 4552 2981221 SGTC_3314 9135860 59.4275 µM -1.70703898790418 0.0416115547395193 no 3221 0.0439074030067281 4578 25252478 SGTC_644 1498-1197 63.3 µM -1.71558038507852 0.0408914462967444 no 3222 0.0431194355545219 4636 6741615 SGTC_766 1391-0721 126 µM -1.71649691361023 0.0408147798400055 no 3223 0.043035566189516 4611 1020919 YIL115C NUP159 SGTC_522 1273-0010 11.6 µM -1.72469195083478 0.0401344464406337 no 3224 0.0422915011973701 4605 5705015 SGTC_224 benfluorex 43.875 µM -1.72820384378702 0.0398457309347717 no 3225 0.0419758424277139 4610 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis. SGTC_1270 0831-1170 17.3 µM -1.72957022967839 0.0397338564699439 no 3226 0.0418535443987437 4610 6764716 SGTC_1464 k208-0027 110 µM -1.74283437243965 0.0386610593042155 no 3227 0.0406812751726241 4589 X1464 SGTC_228 caffeine 993.056 µM -1.74305708233454 0.038643250112783 no 3228 0.0406618221673394 4597 2519 Caffeine is a phosphodiesterase inhibitor. SGTC_951 1171-0579 82.7 µM -1.74526360916748 0.0384671642071735 no 3229 0.040469496673954 4536 1616050 YPR165W | YDR526C RHO1 | YDR526C SGTC_477 mead ethanolamide 10 µM -1.74548549245782 0.0384494936576874 no 3230 0.0404501977983738 4615 16061185 SGTC_2772 vinpocetine 57.06 µM -1.74600536182163 0.0384081177247303 no 3231 0.0404050100725116 4599 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor. SGTC_1133 3473-0247 50 µM -1.74657038402009 0.0383631892866739 no 3232 0.0403559440962791 4574 711311 SGTC_2936 9038235 15.59 µM -1.76611116176081 0.0368355578413774 no 3233 0.0386886006199692 4540 4749415 SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM -1.7777117226518 0.0359524417145726 no 3234 0.037725606685374 4598 756377 SGTC_2208 7283366 200 µM -1.79761616783706 0.034477627148592 no 3235 0.036118927220794 4628 898663 SGTC_1691 st019933 84.6 µM -1.8069077603425 0.0338063854296345 no 3236 0.0353883311773592 4626 6176082 SGTC_2678 equilin 100 µM -1.80926551126495 0.0336377781853537 no 3237 0.0352048821597371 4645 3247 Equilin is an estrone commonly used hormone replacement therapy SGTC_2755 lomerizine 42.69 µM -1.81132222533015 0.0334912643930427 no 3238 0.0350454936311425 4571 3949 A calcium channel blocker. SGTC_186 3455-3465 67.277 µM -1.81604912240303 0.0331565257854225 no 3239 0.0346814185938885 4664 755278 SGTC_2899 9053889 58.44 µM -1.82197016758085 0.0327411162153877 no 3240 0.0342297561669498 4638 6470052 SGTC_161 4065-0411 162.148 µM -1.83876203423929 0.0315863177654828 no 3241 0.0329750973353873 4624 1906281 YLR208W SEC13 SGTC_72 0744-0168 198.391 µM -1.84711433726106 0.031024577495298 no 3242 0.0323652854987769 4538 677577 SGTC_2077 5212015 200 µM -1.8477448799063 0.0309825076076571 no 3243 0.032319629079448 4584 780900 SGTC_1895 st058434 18.3 µM -1.84884631406542 0.0309091330371943 no 3244 0.0322400037960828 4641 5393175 SGTC_872 0588-0139 234 µM -1.85124136541792 0.03075007750515 no 3245 0.0320674186193925 4620 2047100 SGTC_21 0849-0113 22.993 µM -1.85761100102421 0.0303303645131927 no 3246 0.0316121375798847 4652 1560156 SGTC_1216 1165-0504 9.65 µM -1.85872503966877 0.0302574474018522 no 3247 0.0315330611772151 4675 6304004 SGTC_718 1130-0073 349 µM -1.86134486838499 0.0300865443347162 no 3248 0.0313477453813912 4649 6740020 SGTC_2747 doxorubicin 7.63 µM -1.87083989294283 0.029473835161217 no 3249 0.0306836381599645 4719 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_2005 4024620 188 µM -1.881416154413 0.0288035863384294 no 3250 0.0299576655293895 4603 236743 SGTC_1989 st071868 50.2 µM -1.88344466370484 0.028676493010968 no 3251 0.0298200661736044 4653 16414057 SGTC_3221 9128209 49.47 µM -1.88479629924033 0.0285920673985708 no 3252 0.0297286724037635 4671 16460723 SGTC_2175 5807670 165.306 µM -1.88943653377796 0.0283038015782888 no 3253 0.0294166797098115 4636 241186 SGTC_3081 9117243 49.47 µM -1.8984465770113 0.0277509762541133 no 3254 0.0288186394601887 4622 45595589 SGTC_3328 9140624 29.0385 µM -1.91046034523799 0.0270278764904713 no 3255 0.0280369837346378 4658 4904392 SGTC_2096 5468907 200 µM -1.91494892817541 0.0267617783233962 no 3256 0.0277495085587914 4678 759785 SGTC_3232 9132874 49.47 µM -1.92233033516606 0.026328942550486 no 3257 0.0272821026405496 4639 3784940 SGTC_2212 7123476 200 µM -1.92339572744052 0.0262669553012221 no 3258 0.0272151852542051 4709 1085715 SGTC_2493 resveratrol 26.09 µM -1.9257884081819 0.0261281875955321 no 3259 0.0270653997253168 4646 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase. SGTC_3177 9107506 49.47 µM -1.92600771189529 0.0261154994205205 no 3260 0.0270517054567624 4662 8897194 SGTC_3246 9135460 32.98 µM -1.93220222738606 0.0257592283502267 no 3261 0.0266672751916962 4671 41446951 SGTC_132 0417-1715 25.805 µM -1.93561740093962 0.0255645538653738 no 3262 0.0264572887835773 4643 6769098 SGTC_996 3970-0799 1.8 µM -1.94539796682114 0.0250138384627586 no 3263 0.0258635496364847 4625 6615648 YGL040C HEM2 SGTC_2097 5376186 200 µM -1.95139917185701 0.024680877348189 no 3264 0.025504789960639 4675 742755 SGTC_987 1497-1013 404 µM -1.95571760164697 0.0244435879664652 no 3265 0.0252492150368068 4676 1676435 SGTC_2758 dehydroepiandrosterone 69.35 µM -1.96041328290728 0.0241877456560756 no 3266 0.0249737522851259 4635 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem] SGTC_2863 9028737 58.44 µM -1.9625197549329 0.0240737082850389 no 3267 0.0248510014779889 4682 6460917 SGTC_1480 1070-0044 41.2 µM -1.96407627093312 0.0239897341976796 no 3268 0.0247606237847626 4715 3124987 SGTC_1447 4239-0816 81.9 µM -1.96641528655567 0.0238640071818927 no 3269 0.0246253295288881 4706 1341554 SGTC_995 3931-2021 34.6 µM -1.97809531326698 0.0232444400953572 no 3270 0.0239589776002724 4662 730143 SGTC_809 3998-0021 90 µM -1.97815685053493 0.0232412120536815 no 3271 0.0239555073974466 4653 715485 SGTC_3230 9131665 49.47 µM -1.99867011087714 0.0221859806064693 no 3272 0.0228220294994842 4706 15943720 SGTC_795 0685-0265 78 µM -2.00026449345324 0.0221056842900823 no 3273 0.0227358554675377 4680 302754 SGTC_1179 1021-1431 9.29 µM -2.00060670922312 0.0220884816258732 no 3274 0.0227173949986657 4688 2840958 SGTC_3287 9117173 37.0625 µM -2.00221838508107 0.0220076169841711 no 3275 0.0226306246010401 4709 2789709 SGTC_2620 irigenin 100 µM -2.00281436722934 0.0219777773861968 no 3276 0.0225986085840982 4651 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro. SGTC_504 lovastatin 124 µM -2.00421784258338 0.0219076431766914 no 3277 0.0225233650361691 4677 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1 SGTC_495 decylubiquinone 155 µM -2.00543336762332 0.0218470539945478 no 3278 0.0224583687460413 4689 2971 A Co-enzyme Q analog. A free radical scavenger. SGTC_405 ebelactone b 50 µM -2.01087806439099 0.0215773909743293 no 3279 0.0221691689263955 4673 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).  SGTC_858 0438-0351 2.77 µM -2.01425624681123 0.0214114957395344 no 3280 0.0219913185281289 4693 2799119 SGTC_3271 9137798 49.47 µM -2.01852544623789 0.0212033881855056 no 3281 0.0217682833802577 4688 6498326 SGTC_3062 9077494 49.47 µM -2.0227214842985 0.0210005166959484 no 3282 0.0215509352892347 4637 16459633 SGTC_2443 5493264 126.67 µM -2.03084238606206 0.0206125483996415 no 3283 0.0211354928869806 4699 5340055 SGTC_1973 st070275 50.2 µM -2.03815863255798 0.0202682372605591 no 3284 0.0207670355210778 4700 17118334 SGTC_1148 3909-7663 27.7 µM -2.03961944471339 0.020200076887207 no 3285 0.0206941219105855 4703 4084526 SGTC_1255 0566-0045 221 µM -2.04530324546566 0.0199367214534931 no 3286 0.0204124854767585 4687 2788469 SGTC_655 k060-0012 42 µM -2.05208106523653 0.0196264890368671 no 3287 0.020080892390209 4714 5994525 SGTC_2143 5623677 140.463 µM -2.05275934429714 0.0195956698992531 no 3288 0.0200479616696729 4680 5375313 SGTC_67 0335-0847 266 µM -2.05831635912562 0.0193447185781597 no 3289 0.0197798874105407 4660 4552207 YOR254C SEC63 SGTC_2327 6189656 200 µM -2.06135197547432 0.0192087890707047 no 3290 0.0196347364835738 4712 5349088 SGTC_1633 st005664 67.9 µM -2.10249031275828 0.0174452962145494 no 3291 0.0177551736765038 4686 2063822 SGTC_1050 3232-1156 69.3 µM -2.10390291604874 0.0173872816540721 no 3292 0.0176934582861455 4689 700529 SGTC_822 1487-0950 154 µM -2.10434073035075 0.0173693344273453 no 3293 0.0176743677633501 4695 1958375 SGTC_2246 7293507 91.5585 µM -2.12250451885133 0.01663856804912 no 3294 0.0168976968135286 4713 887656 SGTC_727 3032-0951 202 µM -2.122722968179 0.01662994199597 no 3295 0.0168885365861686 4739 3652836 SGTC_1654 st012436 41.8 µM -2.12838119399031 0.0164078414385865 no 3296 0.0166527455445028 4731 4323132 SGTC_501 nsc-95397 161 µM -2.13681198808807 0.0160816237541224 no 3297 0.0163066433435554 4703 262093 SGTC_571 k831-0106 44.2 µM -2.13970804271121 0.0159708550425987 no 3298 0.0161891843380591 4646 4783639 SGTC_3082 9117008 49.47 µM -2.14540493975894 0.0157548670666658 no 3299 0.0159602422476799 4714 41448529 SGTC_3133 9127736 49.47 µM -2.15126619411288 0.0155352675317554 no 3300 0.0157275974769514 4699 27243420 SGTC_1680 diphenhydramine 100 µM -2.15520327071868 0.0153892392536312 no 3301 0.0155729655454349 4667 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1 SGTC_1507 4075-3230 155 µM -2.17150977662823 0.0147969047734147 no 3302 0.0149463294655946 4687 659771 SGTC_968 1309-0633 340 µM -2.17307899073121 0.0147409512458696 no 3303 0.0148871863257147 4735 3761976 SGTC_810 3825-7150 143 µM -2.1763703996243 0.014624180329204 no 3304 0.0147637876490594 4712 22330411 YGL099W LSG1 SGTC_2363 9053361 176 µM -2.17674409645284 0.0146109729545499 no 3305 0.0147498330991794 4701 6469797 YMR079W SEC14 SGTC_665 3914-0008 307 µM -2.17745425165791 0.0145859025883771 no 3306 0.0147233458174414 4710 1069549 SGTC_290 2043-6722 48.1 µM -2.19270787644413 0.0140562772447023 no 3307 0.0141642164483083 4733 773758 YLR208W SEC13 SGTC_2159 5658611 73.75 µM -2.22015939557249 0.013144810406788 no 3308 0.0132039747569757 4718 793844 SGTC_1938 st074717 56.4 µM -2.23366850626631 0.0127153377528251 no 3309 0.0127524463434489 4656 17250979 SGTC_2638 epoxomicin 18 µM -2.23722185348657 0.0126044093379755 no 3310 0.0126359218714786 4706 9915668 A protesome inhibitor. SGTC_1098 clofazimine 15.1 µM -2.24865290092922 0.0122532178032246 no 3311 0.0122672939599229 4751 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2 SGTC_1739 st037196 92.5 µM -2.25763671157949 0.0119831927432353 no 3312 0.0119841589539305 4723 612214 SGTC_686 1319-0111 510 µM -2.28718848216834 0.0111310439269598 no 3313 0.0110924120050988 4737 4562600 SGTC_3145 9085516 49.47 µM -2.32500370076525 0.0101178210110961 no 3314 0.0100358811577054 4713 25236195 SGTC_964 1287-0107 19.4 µM -2.38464864820707 0.0086830556788373 no 3315 0.00854771995679062 4737 51516812 YPR165W RHO1 SGTC_850 0388-0143 75.9 µM -2.38504195457058 0.0086742196821654 no 3316 0.0085385868419642 4764 67273 SGTC_1351 1496-0003 46.5 µM -2.38832937117333 0.00860067266547142 no 3317 0.00846258278932934 4763 3891978 SGTC_164 4100-3994 89.624 µM -2.40863716035879 0.00815835232285597 no 3318 0.00800610413500271 4714 4615967 SGTC_3059 1327-0034 3 µM -2.40950552301682 0.00813989259117872 no 3319 0.00798707714135436 4658 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_3139 9095020 49.47 µM -2.41095396527911 0.00810918313591594 no 3320 0.00795542828121208 4692 25236292 SGTC_2905 7799065 20.05 µM -2.42307742541507 0.00785611263044012 no 3321 0.00769482314025044 4713 1296806 SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM -2.47588980737125 0.00683297186014682 no 3322 0.00664522952557892 4727 6728940 SGTC_3149 9097855 49.47 µM -2.47605387668605 0.00682998600398671 no 3323 0.00664217650278127 4736 25236625 YMR079W SEC14 SGTC_1558 st069300 45.6 µM -2.49476752828433 0.00649689249685705 no 3324 0.0063019837428991 4764 24208000 SGTC_1746 st038117 42 µM -2.51372123691926 0.00617425413412651 no 3325 0.00597324106846789 4754 2898218 SGTC_1101 ebselen 5.29 µM -2.51447941135564 0.0061616486753295 no 3326 0.00596041313801079 4777 3194 A potent scavenger of hydrogen peroxide and hydroperoxides. SGTC_865 0488-0499 301 µM -2.53035554294846 0.00590287651035287 no 3327 0.00569734977629432 4735 9634651 SGTC_376 3970-0862 59.1 µM -2.54980806283843 0.00559898225101399 no 3328 0.00538911198367275 4769 3135186 SGTC_2297 7971671 152.32 µM -2.57311318544925 0.00525325502496909 no 3329 0.00503941202895089 4750 909016 SGTC_960 1222-0186 7.7 µM -2.57580803699307 0.00521452831270148 no 3330 0.00500030751735497 4749 3126296 SGTC_466 geldanamycin 89.2 µM -2.57600421192246 0.00521171909946623 no 3331 0.00499747143952218 4787 5288382 HSP90 inhibitor. SGTC_575 k072-0246 11.9 µM -2.63967655025523 0.00436804319020137 no 3332 0.00414925933467435 4795 6796779 SGTC_3262 9137218 49.47 µM -2.6618470363214 0.00410428782227059 no 3333 0.00388565926391038 4781 17650664 SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM -2.669335680575 0.00401847274812242 no 3334 0.00380007254310207 4777 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding. SGTC_2954 9074818 52.69 µM -2.68649152785172 0.00382790473287375 no 3335 0.00361033896782318 4766 16648742 SGTC_808 0711-0032 135 µM -2.70284208903229 0.00365386264256825 no 3336 0.00343746996399638 4770 4252555 SGTC_3252 9135871 49.47 µM -2.72710654775257 0.00340865427100166 no 3337 0.00319462021598608 4786 17682838 SGTC_2103 5378138 10 µM -2.79937869657386 0.00276346735476843 no 3338 0.00256005250748962 4800 244142 SGTC_1212 0520-0165 585 µM -2.87522877201797 0.0022068178552987 no 3339 0.00201867426031418 4774 5403258 SGTC_1288 0973-0013 65.5 µM -2.88459829756673 0.00214562388045094 no 3340 0.00195956693282699 4791 4315430 SGTC_3238 9133470 49.47 µM -2.91689008749919 0.00194632870902917 no 3341 0.00176770165884297 4788 3534688 SGTC_1994 st072947 40.9 µM -2.94876619193824 0.0017662387251426 no 3342 0.00159522623871583 4794 5286565 YDL195W SEC31 SGTC_3265 9137266 49.47 µM -3.10018707375612 0.00110065775738923 no 3343 0.000966992254283944 4790 17224265 SGTC_1748 st037455 53.6035 µM -3.10027629984689 0.00110034476455948 no 3344 0.000966700978075458 4777 580690 SGTC_848 0368-0089 85.6 µM -3.16191742912646 0.000902602741583832 yes 3345 0.000783670000472247 4797 762535 SGTC_759 3486-0358 89.3 µM -3.18868932618077 0.000827360446996325 yes 3346 0.00071459693173875 4794 875103 SGTC_2336 9001819 198.65 µM -3.23916484164872 0.000700976242930226 yes 3347 0.000599401335535724 4783 2989602 SGTC_3084 9116877 49.47 µM -3.24571280037498 0.000685954269285585 yes 3348 0.000585784834843165 4793 27241325 SGTC_2751 anetholtrithion 17.25 µM -3.2846419937174 0.00060260677615666 yes 3349 0.000510560151333639 4775 2194 A chloretic substance that stimulates the liver to produce bile. SGTC_3225 9130819 49.47 µM -3.35630485324125 0.000473148893889737 yes 3350 0.000394957224967786 4800 4547121 SGTC_2483 5729050 27.16 µM -3.42893785949149 0.000368634081409702 yes 3351 0.000302974123130726 4793 2865180 SGTC_1203 3992-3522 103 µM -3.86439020372805 7.50683471636917e-05 yes 3352 5.56835350349331e-05 4791 5322312 SGTC_2963 9082507 9 µM -3.89181233197932 6.75394502619005e-05 yes 3353 4.974909811021e-05 4803 16459611 SGTC_997 3996-0078 137 µM -4.26745514914878 1.48698352399678e-05 yes 3354 9.88577526138029e-06 4808 735687 SGTC_2835 9006588 71.43 µM -4.45865418410208 6.56599357532969e-06 yes 3355 4.12379297762632e-06 4795 2345538 SGTC_1970 st070122 35.8 µM -5.56969726710768 3.01247153083709e-08 yes 3356 1.2759116297645e-08 4810 102928