SGTCid condition conc unit RSC8|YFR037C.score RSC8|YFR037C.strain.pval RSC8|YFR037C.strain.significant RSC8|YFR037C.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene
SGTC_643 k048-0106 28.4 µM 19.3914532148276 1.79472098060624e-34 yes 1 4.55627796113567e-84 2 6763920
SGTC_227 fluconazole 33.516 µM 15.5383943517034 7.17958786243711e-23 yes 2 9.53508638715246e-55 7 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C
SGTC_2041 5107442 45.335 µM 14.2061207055109 1.92662820651881e-19 yes 3 4.19744059951393e-46 2 793005
SGTC_2186 6124449 200 µM 14.0212596740053 5.45673984293517e-19 yes 4 5.77726876244924e-45 3 3834182 YLR033W RSC58
SGTC_1652 st011932 78 µM 13.9607664845455 7.64961067276684e-19 yes 5 1.35254443596058e-44 7 1551076
SGTC_2912 7964298 10.93 µM 13.5766702285195 6.32081258270727e-18 yes 6 2.75368976076265e-42 7 2975850
SGTC_2348 9022543 33.42 µM 13.4742621352511 1.09928524417108e-17 yes 7 1.10845237699325e-41 4 3162678 YDL140C RPO21
SGTC_2378 9074213 121.43 µM 13.1808477801271 5.247484909703e-17 yes 8 5.65562655486416e-40 2 657714
SGTC_2534 helenine 20.12 µM 12.9002254415972 2.26810200591823e-16 yes 9 2.24391173152778e-38 2 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58
SGTC_2225 6654152 15.4 µM 12.3437059965096 3.77805529424897e-15 yes 10 2.6337161036905e-35 4 97582 YGR029W | YLR033W ERV1 | RSC58
SGTC_2233 sulbentine 40.3845 µM 12.0102080783442 1.92497612527172e-14 yes 11 1.57026928427931e-33 6 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58
SGTC_2361 9034121 116 µM 11.3564297402281 4.13651945842156e-13 yes 12 3.44516905354017e-30 1 6496917
SGTC_673 1082-0474 110 µM 11.1199945848506 1.2044966341604e-12 yes 13 5.01390395793061e-29 8 3098046
SGTC_1374 2889-5571 141 µM 10.7754398298334 5.5017748468968e-12 yes 14 2.24814010570178e-27 12 2853281
SGTC_2408 sulbentine 18.36 µM 10.6254406486229 1.05075189815096e-11 yes 15 1.13468931068863e-26 3 67686 An antifungal agent of unknown mechanism. YDL205C HEM3
SGTC_3304 9125678 46.087 µM 10.5585795294557 1.39811349134675e-11 yes 16 2.31812144748433e-26 11 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2
SGTC_248 streptozotocin 5.23457 mM 10.5390353132885 1.51935883175335e-11 yes 17 2.85407031616695e-26 1 5300 DNA alkylating agent.
SGTC_1707 st032323 6.317 µM 10.3724772606381 3.06814074834268e-11 yes 18 1.65417540396327e-25 7 3132057 YMR211W DML1
SGTC_2544 sphondin 68.51 µM 10.2594601821146 4.9129450239161e-11 yes 19 5.36524527731694e-25 6 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31
SGTC_237 nikkomycin 200 µM 10.2334827571957 5.47064242272239e-11 yes 20 7.01891150202602e-25 1 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine.
SGTC_2930 9013230 14.89 µM 10.06867281087 1.0756631609109e-10 yes 21 3.79983191587271e-24 6 2995857
SGTC_1693 xanthone 101.9 µM 9.97638999942754 1.56357152735224e-10 yes 22 9.66873021272918e-24 1 7020 An insecticide.
SGTC_2575 plumbagin 510 nM 9.95302664522618 1.71798052871613e-10 yes 23 1.22313900330301e-23 2 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_3288 9119690 36.221 µM 9.93655338745597 1.83570165023338e-10 yes 24 1.44320761720947e-23 4 17595618 YKL019W RAM2
SGTC_2109 5483026 200 µM 9.88139407231122 2.29009479492256e-10 yes 25 2.506529076031e-23 9 759335
SGTC_2229 7354935 190 µM 9.84083101759942 2.69255435248037e-10 yes 26 3.75440077680978e-23 3 318112
SGTC_709 3807-1509 243 µM 9.83656980858492 2.73863943384851e-10 yes 27 3.91681192986215e-23 4 1886677 YPL242C IQG1
SGTC_3321 9137793 26.8275 µM 9.47076999718937 1.14545425512343e-09 yes 28 1.38894170243923e-21 2 4904192
SGTC_2344 7990960 76.95 µM 9.26912863694859 2.46619819076209e-09 yes 29 9.38363972650952e-21 8 140813
SGTC_157 1348-1695 65.819 µM 9.25338760081277 2.61663541829029e-09 yes 30 1.087440301522e-20 7 5380510
SGTC_64 000l-0018 272.079 µM 9.11401684032549 4.40180795202884e-09 yes 31 3.96934884301201e-20 14 6811119
SGTC_2346 9031566 143.75 µM 8.97451094237617 7.35377797383323e-09 yes 32 1.42306674859642e-19 2 4771086
SGTC_871 0574-0004 149 µM 8.97100518821452 7.44851770460872e-09 yes 33 1.46910308312985e-19 9 9551173
SGTC_257 daunorubicin 18.5 µM 8.95098440118952 8.01270756869459e-09 yes 34 1.76163082084207e-19 4 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_69 0096-0274 206.684 µM 8.90862441703601 9.34654507870565e-09 yes 35 2.58348145667795e-19 8 6741392
SGTC_268 camptothecin 39.6153 µM 8.90668432182236 9.41253758663669e-09 yes 36 2.62907537736332e-19 9 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_177 1327-0068 8.361 µM 8.74286697642424 1.69615983002114e-08 yes 37 1.13634108328245e-18 5 15389900 YOR207C | YLR033W RET1 | RSC58
SGTC_1168 k815-0004 80.5 µM 8.57919959449229 3.02381265497372e-08 yes 38 4.77677885863948e-18 3 642433
SGTC_951 1171-0579 82.7 µM 8.4446595742511 4.82657010876101e-08 yes 39 1.52466381329785e-17 3 1616050 YPR165W | YDR526C RHO1 | YDR526C
SGTC_219 mitoxanthrone 164.414 µM 8.32929388345904 7.1679709920401e-08 yes 40 4.06629773057596e-17 3 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA. YMR168C CEP3
SGTC_1050 3232-1156 69.3 µM 8.30125511416046 7.88512296188574e-08 yes 41 5.15086064164884e-17 4 700529
SGTC_1133 3473-0247 50 µM 8.14994853368721 1.31232775461618e-07 yes 42 1.82039593517121e-16 13 711311
SGTC_158 k038-0087 26.446 µM 8.07322318855078 1.69349160581345e-07 yes 43 3.42331448723123e-16 7 X158
SGTC_2051 5263410 176 µM 8.03649302920677 1.91184850627097e-07 yes 44 4.62231030267799e-16 1 227584
SGTC_22 0964-0034 14.468 µM 7.97187986297792 2.36356670027132e-07 yes 45 7.81393452129664e-16 5 138402
SGTC_2336 9001819 198.65 µM 7.93450896247741 2.67012017009592e-07 yes 46 1.05664880573989e-15 15 2989602
SGTC_1651 st011928 86.1 µM 7.89677542883183 3.01838207319599e-07 yes 47 1.431056877425e-15 2 720198
SGTC_86 0417-1630 471.922 µM 7.72377082848451 5.25881908090724e-07 yes 48 5.64689080551487e-15 5 3634867
SGTC_2111 5486399 200 µM 7.61876432021113 7.32541957821283e-07 yes 49 1.28057796794179e-14 9 689674
SGTC_2375 9072683 200 µM 7.38816033824576 1.49481779465331e-06 yes 50 7.44370790734693e-14 1 16798029
SGTC_2387 9077560 195.08 µM 7.2143773796111 2.52495373925604e-06 yes 51 2.70906523452677e-13 1 5303272
SGTC_1991 st073000 8.92 µM 7.21007833462136 2.5575413274749e-06 yes 52 2.79598491965288e-13 5 4301969 YIL048W NEO1
SGTC_885 0865-0106 16.8 µM 7.202445717295 2.61639276351912e-06 yes 53 2.95709952122386e-13 3 2793380
SGTC_2029 5175081 200 µM 7.2009689129866 2.62792842559215e-06 yes 54 2.98930893211675e-13 1 1380876
SGTC_1803 st050068 52.4 µM 7.09278701287095 3.61910176265426e-06 yes 55 6.57188335995119e-13 5 3984059 YIL048W | YNL267W NEO1 | PIK1
SGTC_2962 9082311 13.18 µM 7.06959867797428 3.87384979458959e-06 yes 56 7.76912038839875e-13 2 16459453
SGTC_16 erodoxin 22.806 µM 6.98377344567818 4.97415072125624e-06 yes 57 1.43677661938902e-12 6 3967339 Erodoxin inhibits Ero1. YML130C ERO1
SGTC_138 0850-0259 40.9225 µM 6.98144705400346 5.00778013161541e-06 yes 58 1.46077505946045e-12 22 6813004
SGTC_1493 4348-0038 111 µM 6.90737526332886 6.19948849449495e-06 yes 59 2.4685136122007e-12 11 800424
SGTC_525 k781-2675 26.7 µM 6.86193319828243 7.05974278833084e-06 yes 60 3.39674164673515e-12 13 3651118 YDL195W SEC31
SGTC_916 4466-0038 42 nM 6.80289104645613 8.34848527262664e-06 yes 61 5.12701001191612e-12 11 5722064 YGL116W CDC20
SGTC_1875 nocodazole 6 µM 6.78874936395092 8.68889715263061e-06 yes 62 5.65548715969249e-12 14 4122 A microtubule depolymerizer. YJL014W CCT3
SGTC_2766 oltipraz 83.91 µM 6.77635816127552 8.99800700792974e-06 yes 63 6.16214680249999e-12 8 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40
SGTC_2510 benzyl isothiocyanate 8.31 µM 6.65568558445604 1.26091111797842e-05 yes 64 1.40991245569622e-11 5 2346 DNA damaging agent; causes G2/M arrest.
SGTC_2400 5203494 178.7 µM 6.5242292951524 1.80974371301557e-05 yes 65 3.41760384872783e-11 4 6777674
SGTC_928 2764-0428 58.7 µM 6.52322331054173 1.81470975261031e-05 yes 66 3.44061464661056e-11 6 662578
SGTC_2890 9046729 58.44 µM 6.44087893146709 2.2681074647598e-05 yes 67 5.9391799039166e-11 4 903329
SGTC_1026 k007-1105 30.6 µM 6.32952996876481 3.05409914729267e-05 yes 68 1.22954565360632e-10 14 7066794
SGTC_2180 6301957 200 µM 6.29331863138991 3.36102776043015e-05 yes 69 1.553747725226e-10 3 845462
SGTC_272 doxorubicin 8.13 µM 6.23805046582373 3.88631197131869e-05 yes 70 2.21528868240552e-10 3 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_590 k048-0076 22.4 µM 6.20659870003999 4.21896085958417e-05 yes 71 2.70718106555385e-10 4 6832814
SGTC_2043 5101342 149 µM 6.15533398819831 4.81946036409202e-05 yes 72 3.74597193487488e-10 1 678451
SGTC_3285 9112818 20.8695 µM 6.10757997778863 5.45067683102525e-05 yes 73 5.0576564067128e-10 4 17017947 YPR165W RHO1
SGTC_324 1315-0088 19.6 µM 6.00373134038992 7.10257353277861e-05 yes 74 9.6416840809709e-10 3 6787421
SGTC_1373 2887-0003 58.5 µM 5.96113549316533 7.90800173384083e-05 yes 75 1.25245576460434e-09 1 776948
SGTC_1229 0139-0193 12.2 µM 5.95197452700659 8.09210536152026e-05 yes 76 1.32463307434056e-09 9 3090752
SGTC_221 trifluoperazine 10.304 µM 5.77474369677062 0.000125532410929931 yes 77 3.85351549309865e-09 17 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1
SGTC_1044 1222-0021 1.78 µM 5.76836797365584 0.000127503317546949 yes 78 4.00214418041365e-09 14 4306703
SGTC_783 0848-0141 92.7 µM 5.7229374750992 0.000142410002238658 yes 79 5.23489023531791e-09 7 6755076 YHR007C | YLR033W ERG11 | RSC58
SGTC_1239 0337-0584 35.4 µM 5.70306850705649 0.000149429730753078 yes 80 5.88348309879103e-09 16 914301 YML130C ERO1
SGTC_322 k048-0136 19.3 µM 5.6801837834471 0.000157916118921623 yes 81 6.72750443153208e-09 3 6823282
SGTC_329 k048-0121 21.3 µM 5.66798601058023 0.000162621742689678 yes 82 7.22428795292467e-09 7 6832902
SGTC_534 k292-0788 63.4 µM 5.65665773126635 0.000167109175604263 yes 83 7.71745654935115e-09 2 4146317
SGTC_746 1095-0025 46.6 µM 5.59183150336989 0.000195098016143062 yes 84 1.12343406270591e-08 4 6749286
SGTC_145 3737-0113 38.366 µM 5.54377891973304 0.0002186088933364 yes 85 1.48006270840261e-08 23 6849351
SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM 5.49981329501245 0.000242412455771285 yes 86 1.90096804725135e-08 3 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair.
SGTC_2405 ticlatone 3.52 µM 5.46591553708037 0.000262392393273568 yes 87 2.30261798942065e-08 9 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W
SGTC_2092 5303694 80.6725 µM 5.40520508050755 0.000302060387131957 yes 88 3.23671412975098e-08 3 1963699
SGTC_1952 st077036 64.1 µM 5.32161975791875 0.000365853521466557 yes 89 5.1423685068966e-08 6 2937007
SGTC_1915 st067105 30.6 µM 5.28219912973875 0.000400096010289365 yes 90 6.38211747174583e-08 25 69751 YOR207C | YOR116C RET1 | RPO31
SGTC_2396 5342950 42.78 µM 5.23316373236921 0.000446839459408252 yes 91 8.33165052316439e-08 17 1886677
SGTC_120 rhodamine 6G 52.259 µM 5.22807573253895 0.000451969103375465 yes 92 8.56416768651383e-08 8 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase
SGTC_2830 7992007 71.43 µM 5.20842770587703 0.000472294562189162 yes 93 9.52237627799341e-08 3 1952075
SGTC_58 0957-0393 9 µM 5.19019745828194 0.000491907488150504 yes 94 1.05035594657884e-07 36 6997992
SGTC_2974 9094440 9.66 µM 5.17186118933869 0.000512392936523104 yes 95 1.15886869951317e-07 7 25236134
SGTC_566 0958-0068 16.5 µM 5.1505001990156 0.000537252124580585 yes 96 1.29896328234552e-07 9 6815365
SGTC_2619 obliquin 87.91 µM 5.14901345993898 0.000539023207693853 yes 97 1.30930046073889e-07 23 6708593 A bioactive alkalod. YER133W GLC7
SGTC_1936 st074407 74.3 µM 5.13047198045767 0.000561569164242344 yes 98 1.44508290222097e-07 6 809813
SGTC_576 1073-0113 22.7 µM 5.12293638886736 0.000570978956109069 yes 99 1.50406927106475e-07 23 5439563
SGTC_1171 0368-0077 21.4 µM 5.11141450817626 0.000585648602611868 yes 100 1.59877760832439e-07 6 3239779
SGTC_2928 9011484 9.79 µM 5.05004426814512 0.000669825242408271 yes 101 2.20853845781287e-07 21 2994751
SGTC_475 α-linolenic acid 10 µM 5.04735647837917 0.000673755279064561 yes 102 2.23982524792452e-07 3 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_483 fpl-64176 144 µM 5.02543439916189 0.000706612572556107 yes 103 2.51147124972081e-07 5 3423
SGTC_531 3788-1495 174 µM 5.01564049159365 0.000721764059427399 yes 104 2.64285418826438e-07 4 2896655
SGTC_804 1595-0054 20.9 µM 5.01279720542009 0.000726218473540638 yes 105 2.68222128685235e-07 1 761523 Stimulates phospholipase C.
SGTC_1844 rapamycin 4 nM 4.99752091461378 0.000750587768462034 yes 106 2.90360210308043e-07 32 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2
SGTC_2679 rapamycin 1 nM 4.9911049646017 0.00076104559873014 yes 107 3.00174302203114e-07 37 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2
SGTC_1511 0906-3109 28.5 µM 4.97344724605901 0.000790524106942898 yes 108 3.28863391921519e-07 5 2882180
SGTC_3120 9124077 49.47 µM 4.92247288470724 0.000881621007546863 yes 109 4.27287041560959e-07 12 18774327 YGL155W CDC43
SGTC_586 0957-0265 8.15 µM 4.92094529219862 0.000884494294839527 yes 110 4.30636025772526e-07 30 6752309 YPR165W | YPR107C RHO1 | YTH1
SGTC_1992 st073643 23.3 µM 4.92075052622528 0.000884861253198384 yes 111 4.31064829237227e-07 4 3161292
SGTC_203 k066-0004 30.888 µM 4.86707181291975 0.000991502477962173 yes 112 5.66319404404393e-07 8 6795412
SGTC_794 k038-0031 316 µM 4.84844300806221 0.00103118649032688 no 113 6.22171344146017e-07 12 6624242
SGTC_432 NS 1619 61.3 µM 4.79852423909385 0.00114481728947901 no 114 7.99194834423874e-07 4 4552 A K+/calcium channel activator.
SGTC_2380 9035439 200 µM 4.78361114223199 0.00118092503371121 no 115 8.60868095105978e-07 5 6462575
SGTC_825 1988-2224 89.6 µM 4.78065607009059 0.00118820250166541 no 116 8.73620273762898e-07 7 1180859
SGTC_964 1287-0107 19.4 µM 4.76227181381912 0.0012344073889339 no 117 9.5712799684905e-07 12 51516812 YPR165W RHO1
SGTC_666 0272-0154 136 µM 4.7512516552114 0.00126288644844134 no 118 1.01080671181418e-06 10 6870312
SGTC_3311 9131146 2.8755 µM 4.73164812482952 0.00131503697144904 no 119 1.11352108956733e-06 13 4900406 YPR165W RHO1
SGTC_895 0964-0006 13.7 µM 4.71238242339017 0.00136819969725484 no 120 1.22418675478415e-06 7 6738897
SGTC_829 1635-0120 117 µM 4.71066713224608 0.00137302688966502 no 121 1.23453611380109e-06 37 285054
SGTC_1754 st042065 16.137 µM 4.69435851690598 0.00141970606734764 no 122 1.33722317046159e-06 21 1126236 YIL048W NEO1
SGTC_915 methyl methanesulfonate (MMS) 110 mM 4.69366111995415 0.0014217341181313 no 123 1.34179223207567e-06 7 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks.
SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM 4.68284757188839 0.00145352057528011 no 124 1.41458449215688e-06 15 279621
SGTC_273 hydroxyurea 18.1 mM 4.67902120425506 0.00146492266331882 no 125 1.44123817578013e-06 15 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12
SGTC_1098 clofazimine 15.1 µM 4.62886393634649 0.0016221235565145 no 126 1.83838620050001e-06 19 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2
SGTC_2561 acetosyringone 100 µM 4.60805989808816 0.0016917224469645 no 127 2.03221794612235e-06 4 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent.
SGTC_1547 harmine 94.2 µM 4.59975941531192 0.00172024210985128 no 128 2.11489578672246e-06 11 5280953 A monoamine oxidase inhibitor YHR072W ERG7
SGTC_103 0844-0104 51.839 µM 4.59325024252245 0.00174291240840905 no 129 2.18197616775897e-06 43 5375804
SGTC_4 0960-0234 25.671 µM 4.58995190982019 0.00175450340738162 no 130 2.21674071137605e-06 8 6821112
SGTC_3293 9120939 62.045 µM 4.56727097023846 0.00183612711133634 no 131 2.4705754531483e-06 6 934087
SGTC_3350 9150499 3.57 µM 4.56537486786687 0.00184310476704408 no 132 2.49301271144239e-06 11 4910996 YPR165W RHO1
SGTC_93 0109-0045 59.227 µM 4.55568032123105 0.00187915888763055 no 133 2.61081493050213e-06 11 88733
SGTC_1082 camptothecin 424.86 nM 4.54701142756085 0.00191194021309278 no 134 2.72065224362623e-06 14 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_795 0685-0265 78 µM 4.52797767000577 0.00198574624064835 no 135 2.9775436429249e-06 9 302754
SGTC_529 4076-0302 30.3 µM 4.51945037449013 0.00201964353145255 no 136 3.10001889351406e-06 4 5816522
SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM 4.50691960484613 0.00207040881512472 no 137 3.28877704180434e-06 5 5379071
SGTC_1638 st008370 60.6 µM 4.5059335777707 0.00207445218364589 no 138 3.30408788113618e-06 13 24207134
SGTC_2973 9094665 17.96 µM 4.49667562575341 0.00211276685803383 no 139 3.45120840080758e-06 13 25237061 YIL048W NEO1
SGTC_1396 3511-0007 98.6 µM 4.48254868372466 0.00217247024016125 no 140 3.68784045482802e-06 3 X1396
SGTC_1457 k015-0032 57.3 µM 4.46773385841829 0.00223672006695992 no 141 3.95262850840498e-06 4 4302660
SGTC_1870 st057514 26.5 µM 4.44649795904982 0.00233182176660453 no 142 4.36407479797942e-06 6 5393161
SGTC_3059 1327-0034 3 µM 4.44062908333923 0.00235874263655593 no 143 4.48481409215574e-06 8 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_1679 SEC14.276 6.7 µM 4.43208258104596 0.00239844924215263 no 144 4.66636288616865e-06 22 1005053 YMR079W SEC14
SGTC_1009 4106-0057 9.87 µM 4.39276254991393 0.00258903330431192 no 145 5.59596724778661e-06 6 2928005
SGTC_2044 5102272 200 µM 4.38488085592891 0.00262884366861177 no 146 5.80246389499245e-06 4 592666
SGTC_1672 st016598 6.51 µM 4.36282495255216 0.00274320364636189 no 147 6.41968367108705e-06 16 4665860 YNL267W PIK1
SGTC_445 e6 berbamine 66 µM 4.31048370102445 0.00303276782919917 no 148 8.14489179104912e-06 25 6610268 A calcium/calmodulin antagonist.
SGTC_1723 st034307 2.5525 µM 4.29923303284565 0.00309849458172923 no 149 8.56950948786055e-06 12 867466
SGTC_1478 0453-0656 35.7 µM 4.29709545285441 0.00311112641563897 no 150 8.65253448777774e-06 9 5258496
SGTC_2037 5169046 200 µM 4.28266751596669 0.00319760649224152 no 151 9.23330040470489e-06 4 5718022
SGTC_2845 9003024 42.97 µM 4.23753845934114 0.00348224593695138 no 152 1.12991859323507e-05 10 2990173
SGTC_1371 2421-0008 32.7 µM 4.22805766077332 0.00354486068307589 no 153 1.17858695330463e-05 21 2827552
SGTC_462 ag-879 158 µM 4.20935384895819 0.00367135978631009 no 154 1.28051019339184e-05 11 6809654 Ag-879 is a 5-Lipoxygenase inhibitor.
SGTC_2370 9071495 200 µM 4.20499641354154 0.00370140586474228 no 155 1.30543148514394e-05 7 21791103
SGTC_2223 6903751 107.57 µM 4.1581664624532 0.00403851447584145 no 156 1.60406109123531e-05 5 5598863
SGTC_2365 9042475 200 µM 4.15410512062066 0.00406900737401425 no 157 1.63281515704737e-05 5 6464479
SGTC_2987 9018338 71.43 µM 4.15186841287154 0.00408588862029927 no 158 1.648859331256e-05 7 5055682
SGTC_2277 7947813 106.88 µM 4.15148773200692 0.00408876799095818 no 159 1.65160487115656e-05 16 1246798
SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM 4.14137126429473 0.00416595472076581 no 160 1.72617811286363e-05 4 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis.
SGTC_708 3448-5400 146 µM 4.12850736335171 0.00426598518279466 no 161 1.82562874580543e-05 16 3462195
SGTC_1665 st014639 11.4 µM 4.1195829226523 0.00433663837945941 no 162 1.89779406175758e-05 7 981133 YIL048W NEO1
SGTC_426 0988-0037 14.6 µM 4.11718986429078 0.00435576075754129 no 163 1.91760055240376e-05 11 5383008
SGTC_2194 5927483 104.545 µM 4.11566751785161 0.00436796465878871 no 164 1.93030241624296e-05 5 760979
SGTC_2799 7812892 81.82 µM 4.05861037362757 0.00484797158406857 no 165 2.46827998842343e-05 16 20205235
SGTC_1199 1638-0010 4.46 µM 4.05849508126141 0.00484898732349951 no 166 2.46949867994176e-05 3 3111136
SGTC_319 1348-1596 45.5 µM 4.0515423571892 0.0049105933997616 no 167 2.54405562270687e-05 7 5380505
SGTC_725 1497-0963 19 µM 4.05113576849141 0.00491421755600178 no 168 2.54848101868858e-05 3 3549977
SGTC_123 0083-0120 66.675 µM 4.0492976364414 0.00493063163266405 no 169 2.56857883760721e-05 11 16001701
SGTC_1085 doxorubicin 7.67 µM 4.0351890799167 0.00505825261374523 no 170 2.72791718744603e-05 5 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_288 1315-0019 35.1 µM 4.03108545923747 0.00509592060958459 no 171 2.77599251968072e-05 20 6811474
SGTC_745 0469-0705 296 µM 4.02030608767046 0.0051960589275185 no 172 2.90612871883796e-05 15 3486736
SGTC_459 nigericin 15.3 µM 3.99942316602234 0.00539505143622697 no 173 3.17485287794805e-05 10 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification.
SGTC_480 am 92016 50 µM 3.97710238264531 0.00561520895768992 no 174 3.48800672690869e-05 4 2129 K+ channel blocker.
SGTC_1931 st074438 57.1 µM 3.96393917047571 0.00574874985298109 no 175 3.68615228241409e-05 11 2787313
SGTC_2343 7990716 14.84 µM 3.95888777739396 0.00580073994590131 no 176 3.76498028213999e-05 3 6456862
SGTC_945 3381-0768 11.3 µM 3.95109471312751 0.00588176639746491 no 177 3.88972635439721e-05 8 1126236 YIL048W NEO1
SGTC_2833 9001315 45.46 µM 3.91630189629117 0.00625589001672668 no 178 4.49588188946448e-05 8 2989378
SGTC_3037 9091026 49.47 µM 3.89862901134719 0.00645387648845997 no 179 4.83694277483286e-05 21 25236398 YIL048W NEO1
SGTC_698 k064-0052 127 µM 3.88662035010887 0.00659155150582031 no 180 5.08247708021416e-05 3 5088751
SGTC_1831 st055328 12 µM 3.88168840075336 0.0066488426520227 no 181 5.18668706199917e-05 15 1103068
SGTC_2140 5586273 200 µM 3.87427855495528 0.00673574538133398 no 182 5.34705178669269e-05 13 854421
SGTC_331 k048-0133 24.5 µM 3.86754797869872 0.00681554996190204 no 183 5.49676017621357e-05 13 6813582
SGTC_3154 9100113 49.47 µM 3.86343120925279 0.0068647732259197 no 184 5.59026945008314e-05 13 25237525
SGTC_3322 9139058 2.11 µM 3.81543897897883 0.00746219188128979 no 185 6.79705238754472e-05 18 4908926 YPR165W RHO1
SGTC_3063 1327-0034 4 µM 3.80560200854275 0.00759015355801309 no 186 7.07298481484873e-05 11 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_2228 7354201 200 µM 3.79929389605823 0.00767322425787679 no 187 7.25544655940147e-05 1 753451
SGTC_262 fenpropimorph 62.5 µM 3.79649151544531 0.00771038447759856 no 188 7.33791915775818e-05 16 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_1 0258-0098 57.368 µM 3.7942018851461 0.00774086299055288 no 189 7.40595617547251e-05 19 6790032 YDR047W HEM12
SGTC_1800 st050079 29.0735 µM 3.78959318817742 0.00780253352548438 no 190 7.54470988273852e-05 29 3645560
SGTC_2257 7960413 200 µM 3.77616093767597 0.00798474781664612 no 191 7.96320537701594e-05 19 2974689 YIL048W NEO1
SGTC_743 1275-0778 158 µM 3.75889113830011 0.0082245109346625 no 192 8.53340353125215e-05 17 2849257 YMR203W TOM40
SGTC_632 0781-2353 4.65 µM 3.73517624140657 0.00856404895793458 no 193 9.37918850073844e-05 21 6811515 YHR007C ERG11
SGTC_509 pifithrin 175 µM 3.7315356652622 0.00861724735733832 no 194 9.51580294597943e-05 3 4817 A p53 inhibitor.
SGTC_3351 9150312 21.596 µM 3.68492911835045 0.00932433496527786 no 195 0.000114383148191578 9 4904905
SGTC_724 3910-0327 137 µM 3.6833373515909 0.00934935566962019 no 196 0.000115100093152365 7 2885483
SGTC_1896 st058441 89 µM 3.68028239810164 0.00939754053125278 no 197 0.000116487899063774 7 688759
SGTC_1818 st052136 56.3 µM 3.68027258749763 0.00939769562020216 no 198 0.000116492381018958 20 674169
SGTC_2971 9092186 9.93 µM 3.67798646814694 0.00943389637396123 no 199 0.000117541214113694 12 25236400
SGTC_63 0099-0242 26.702 µM 3.64416293055715 0.00998391776393551 no 200 0.000134131724202105 27 3898502 YLR359W ADE13
SGTC_733 4069-0007 56.1 µM 3.63656120721566 0.0101113177252358 no 201 0.000138151005988988 24 5717425 YNL287W SEC21
SGTC_430 0958-0115 16.4 µM 3.63534552039035 0.0101318228647288 no 202 0.00013880415385897 12 6833180
SGTC_235 0330-0087 5 mM 3.63225639088989 0.0101840908947463 no 203 0.000140476882553826 6 46494818 YHR062C RPP1
SGTC_2917 7979103 53.79 µM 3.61660835756954 0.0104524843712012 no 204 0.000149244199194867 8 2980565
SGTC_2563 tomatine 8.54 µM 3.60867796663973 0.010590844355314 no 205 0.000153880678690322 16 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties.
SGTC_707 0865-0008 204 µM 3.58745958250569 0.010968909850555 no 206 0.000166957736178017 5 723043
SGTC_36 0335-0881 14.2 µM 3.58250876917899 0.0110587936953461 no 207 0.000170155094520685 39 23828853
SGTC_2188 6126565 140.678 µM 3.55489004037936 0.0115720684023321 no 208 0.000189068597280431 9 874518
SGTC_1468 k284-1086 134 µM 3.50525668852051 0.0125465856518005 no 209 0.000228083621772807 15 15996457
SGTC_2696 st077691 74.316 µM 3.49960499256934 0.0126619351143829 no 210 0.000232974033575077 15 757133
SGTC_1899 st063254 59.6 µM 3.49143581935863 0.0128302871094089 no 211 0.000240215937840123 9 3093813
SGTC_1686 st019653 115.5 µM 3.46532079472427 0.0133815226250696 no 212 0.00026479967402801 6 97252
SGTC_2183 6420625 130.508 µM 3.45839449575063 0.0135311102396041 no 213 0.000271702529319911 24 2897619
SGTC_217 ketoconazole 989 nM 3.44581156403652 0.0138065594328017 no 214 0.000284673610694778 15 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4
SGTC_1684 st024538 14.6195 µM 3.43009748968697 0.0141573313967997 no 215 0.000301682211809881 4 6732859
SGTC_1534 6-azauridine 81.6 µM 3.42799720958598 0.0142047909923727 no 216 0.000304025854859159 10 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1
SGTC_1481 3346-2004 36 µM 3.41905198888954 0.0144084623934606 no 217 0.000314198594277823 5 2770522
SGTC_255 tunicamycin 200.472 nM 3.41069950530126 0.0146009028568747 no 218 0.000323982301586342 17 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_2308 7584454 197.62 µM 3.40580542088659 0.0147146865858899 no 219 0.000329845892079527 15 893577
SGTC_212 3807-4682 38.772 µM 3.39066335385427 0.0150715714893381 no 220 0.000348618444077007 32 3125501 YBL034C STU1
SGTC_1188 1403-0014 4.57 µM 3.38979272555018 0.0150923156458069 no 221 0.000349727438697098 17 9614867
SGTC_2582 agaric acid 100 µM 3.38581320844859 0.0151874468723004 no 222 0.00035483835992955 40 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase.
SGTC_2001 4023502 57.655 µM 3.36910856442048 0.0155924152614366 no 223 0.000377058597845023 10 108941 YCR052W RSC6
SGTC_2718 lomofungin 53.02 µM 3.36267991321441 0.015750715201357 no 224 0.000385949044311472 13 5351222 A RNA synthesis inhibitor.
SGTC_863 0466-0191 129 µM 3.29117976132053 0.0176062860858471 no 225 0.000498840687792872 22 765160 YPR165W RHO1
SGTC_351 caspofungin 25 nM 3.2895703119663 0.0176501154196642 no 226 0.00050170241674235 43 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1
SGTC_1437 4092-1038 11.6 µM 3.26067205606925 0.0184530750554552 no 227 0.000555742551637725 8 3977136
SGTC_1195 1502-0147 41.1 µM 3.25963539290685 0.0184824483066982 no 228 0.00055777760711581 12 817940
SGTC_1317 1273-0028 910 nM 3.25360883275658 0.0186539970867784 no 229 0.000569745337357353 23 5917803 YLR359W | YHR072W ADE13 | ERG7
SGTC_26 0302-0163 425.158 µM 3.22511006545398 0.019483699384752 no 230 0.000629621231618966 16 3100915
SGTC_1544 7-methoxy-4-methylcoumarin 105 µM 3.21960313345034 0.0196475888502695 no 231 0.000641840880726349 12 390807
SGTC_624 k048-0052 28 µM 3.21396536370987 0.0198165832065159 no 232 0.000654577321355381 13 6835531
SGTC_1727 st034309 9.9045 µM 3.20818720957114 0.0199910641764562 no 233 0.000667872593813135 28 870305
SGTC_642 0335-0876 158 µM 3.20772756536578 0.0200049996872941 no 234 0.000668940840797174 18 6812350
SGTC_2006 4011487 200 µM 3.20084154960272 0.0202147586551131 no 235 0.000685134308729921 31 45595294
SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM 3.19576254171209 0.0203706656917932 no 236 0.000697309186425993 6 66535 A nucleotide analog.
SGTC_2412 st077135 33.4 µM 3.19465583782754 0.0204047723642871 no 237 0.000699988397717169 11 13258915
SGTC_808 0711-0032 135 µM 3.18367248496304 0.020745891287007 no 238 0.000727097229410737 17 4252555
SGTC_1266 0828-0227 32.9 µM 3.18295269882313 0.020768413883618 no 239 0.000728907137881034 20 3913820
SGTC_2132 5317594 122.667 µM 3.17974640649477 0.0208689926303704 no 240 0.000737019940598597 11 794577
SGTC_1207 2099-0101 141 µM 3.17201758675827 0.0211131354833818 no 241 0.000756919195667609 9 5837381
SGTC_1346 1488-2224 62.4 µM 3.17022088934389 0.0211702355818888 no 242 0.000761615470298766 23 3722427
SGTC_216 k038-0035 28.382 µM 3.16799097664009 0.0212412851413261 no 243 0.000767481422667236 31 4444231 YPR107C YTH1
SGTC_2374 9071832 200 µM 3.16763795896903 0.0212525514731625 no 244 0.000768413868122539 12 17381698
SGTC_2549 cedrol 20.94 µM 3.1651018919209 0.0213336370803279 no 245 0.000775143257357683 24 6708665 A sedative which affects the nervous system.
SGTC_1584 6-fluoro-dl-tryptophan 90 µM 3.15099147000784 0.0217895810160049 no 246 0.000813586211565605 11 94937 An inhibitor of serotonin biosynthesis.
SGTC_1213 1315-0166 115 µM 3.14459025274945 0.0219991190612599 no 247 0.000831598000258106 29 768401
SGTC_2826 7992541 19.48 µM 3.13976878096716 0.0221580665431106 no 248 0.000845406143565802 8 2985066
SGTC_722 3534-0461 190 µM 3.13356164407778 0.0223641206980826 no 249 0.000863493196022544 7 658262
SGTC_898 1000-0849 28.3 µM 3.11166510669374 0.023103958022085 no 250 0.00093017705437772 11 6751807
SGTC_3156 9099931 49.47 µM 3.10392201116345 0.0233704659323239 no 251 0.000954868318949678 10 18111053
SGTC_2963 9082507 9 µM 3.10137285640703 0.0234587688265207 no 252 0.000963127871111859 18 16459611
SGTC_2519 cryptotanshinone 88.04 µM 3.09592813279556 0.0236483147896524 no 253 0.000980989538354525 33 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE)
SGTC_2187 6125751 200 µM 3.09425916838281 0.0237066733585926 no 254 0.000986525242143325 23 874498
SGTC_3331 9141060 1.957 µM 3.07756892367762 0.0242969691503038 no 255 0.0010434828526326 16 4906567 YPR165W RHO1
SGTC_2149 5554786 194.827 µM 3.07636931564122 0.0243398678536037 no 256 0.00104769066396488 15 745063 YPR165W RHO1
SGTC_558 k064-0027 21.3 µM 3.06872977727266 0.0246145569455502 no 257 0.00107485470537852 27 5088526
SGTC_1789 tunicamycin 25 nM 3.0672536597157 0.0246679313491782 no 258 0.00108017722224037 27 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_2334 9017922 200 µM 3.0655025131835 0.024731376322472 no 259 0.00108652275631115 12 3163164
SGTC_3247 9135149 49.47 µM 3.06424208356582 0.0247771270359433 no 260 0.00109111123637278 38 8934436 YOR116C RPO31
SGTC_1623 st003709 20.3 µM 3.06106496173885 0.02489276438894 no 261 0.00110275618709221 14 16192618
SGTC_1367 1812-0510 76.9 µM 3.04952753365562 0.0253165035006829 no 262 0.00114600811285919 12 1142582 YDR527W RBA50
SGTC_1425 4048-4433 7.33 µM 3.04506240672367 0.0254821097730856 no 263 0.00116316016720903 12 23734946
SGTC_1049 3226-0134 66 µM 3.04248406598899 0.0255781498933532 no 264 0.00117317119579379 16 5702385
SGTC_1279 0874-0590 65.2 µM 3.03770057500881 0.025757131992219 no 265 0.00119195348863488 8 3523074
SGTC_2647 atorvastatin 60.16 µM 3.03573619141715 0.0258309356140181 no 266 0.00119974603202246 9 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7
SGTC_970 1315-0089 19.5 µM 3.03524670122533 0.0258493537089122 no 267 0.00120169504253258 18 6811083 YLR033W RSC58
SGTC_2475 5812728 15.03 µM 3.02061378816316 0.0264050431246013 no 268 0.00126131450948894 26 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2
SGTC_842 0271-0008 11.1 µM 3.01079784117974 0.0267833739629303 no 269 0.00130281132826732 26 1221709
SGTC_2452 5863136 48.41 µM 3.00541096987762 0.0269929139230497 no 270 0.00132611113749974 10 2184096
SGTC_3050 9093513 49.47 µM 2.98064602394082 0.0279739095192548 no 271 0.00143820532623495 14 25236664
SGTC_2019 4016004 108 µM 2.98050642327481 0.0279795224774403 no 272 0.00143886101445456 24 45595336
SGTC_3327 9140648 26.9345 µM 2.97986155123838 0.0280054631811868 no 273 0.001441893447275 37 8029710
SGTC_1622 st003707 19.4 µM 2.97924217587311 0.0280303971067958 no 274 0.00144481147640739 13 10140899
SGTC_2449 5812982 45.77 µM 2.97555996188648 0.0281790123270448 no 275 0.00146227085264613 15 776185
SGTC_2124 5246320 200 µM 2.97250784664895 0.028302693243255 no 276 0.00147688829985534 47 579342
SGTC_163 TUB2.036 7.546 µM 2.94180590329488 0.0295721415742868 no 277 0.0016315219007776 70 15992207 YJR013W GPI14
SGTC_1722 st034304 3.6505 µM 2.92345966052958 0.0303530217883416 no 278 0.00173082538062832 26 4036148 YLR033W RSC58
SGTC_1661 st013063 9.66 µM 2.92090685921784 0.0304630200302951 no 279 0.00174507076001532 13 721395
SGTC_3318 9139014 38.6185 µM 2.90388095548231 0.0312051282423249 no 280 0.00184284135933844 23 16643984
SGTC_2837 9008476 45.46 µM 2.89994382712691 0.031378848059421 no 281 0.00186614769846824 17 2992805
SGTC_839 0122-0028 230 µM 2.89264697895754 0.0317029246926276 no 282 0.00191005199137374 59 759448
SGTC_1565 sinapyl alcohol 95.1 µM 2.87508503216463 0.0324942573799052 no 283 0.00201959351042241 15 5280507 A phenol propionate derived from cinnamic acid.
SGTC_156 3474-0145 5.642 µM 2.8692100660707 0.0327625903506067 no 284 0.00205749201627602 16 2265471
SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM 2.86912175985091 0.0327666375399162 no 285 0.00205806655688147 15 616764
SGTC_294 k038-0071 157 µM 2.85870900165182 0.0332467658033113 no 286 0.00212684397267863 33 24152826
SGTC_1309 pyrazolanthrone 13.4 µM 2.8465735904835 0.0338136214047242 no 287 0.00220962567759128 27 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14
SGTC_2961 9083290 32.55 µM 2.84200688017813 0.0340289851344445 no 288 0.00224152620475814 9 17741490
SGTC_1274 0865-0114 173 µM 2.83933338905688 0.0341555882314512 no 289 0.00226039483181365 29 870624
SGTC_3005 9076496 71.4286 µM 2.8369665765306 0.0342679914864744 no 290 0.00227721897340471 10 21368410
SGTC_1635 st007035 42.4 µM 2.83245511358345 0.0344830893105106 no 291 0.00230960255016654 37 3716403
SGTC_1752 st044819 83.042 µM 2.83072905732346 0.0345656771710561 no 292 0.00232210219131129 25 441209 YML126C ERG13
SGTC_2662 daunorubicin 22.37 µM 2.82325190397288 0.0349253204318502 no 293 0.0023769601675795 34 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_2430 5571206 200 µM 2.81393164229327 0.0353779099351717 no 294 0.00244698169956368 37 1731771
SGTC_1944 st076371 56.9 µM 2.80599001735721 0.0357673382792147 no 295 0.00250811231678896 14 24208455
SGTC_514 4466-0038 2.65 nM 2.80434363160041 0.0358485090456522 no 296 0.00252095686554393 61 5722064
SGTC_2105 5350118 200 µM 2.79529885711369 0.036297134312693 no 297 0.00259258785137892 20 2133313
SGTC_2326 6164455 177.58 µM 2.78712856169724 0.0367063259041145 no 298 0.00265886888020951 33 2888790
SGTC_2181 6316240 54.2555 µM 2.78059139507277 0.0370364361977352 no 299 0.0027129991967574 13 12779990
SGTC_2612 dictamnine 15.46 µM 2.77587266570531 0.037276224840913 no 300 0.00275268827065939 54 68085 A quinoline derivative and established mutagen. YOR116C RPO31
SGTC_1625 st003711 30.1 µM 2.77581828153643 0.0372789958220875 no 301 0.00275314873287344 13 24207034 YER133W GLC7
SGTC_2617 dihydrotanshinone i 20.83 µM 2.7748895836855 0.0373263407972973 no 302 0.00276102260873475 43 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12
SGTC_695 3505-6186 243 µM 2.76557717494482 0.0378038078810275 no 303 0.00284110789602752 31 1819379
SGTC_1815 st051655 58.2 µM 2.75761448902283 0.038216014475547 no 304 0.00291124099512624 37 5984156
SGTC_342 k048-0088 23.3 µM 2.7472946579902 0.0387556896973263 no 305 0.00300445614154163 30 6820570
SGTC_634 1611-4317 11.2 µM 2.7332132336896 0.0395020756154967 no 306 0.00313598564416331 23 2843522
SGTC_2556 citropten 84.59 µM 2.72963661070556 0.0396935051177645 no 307 0.00317020865301342 21 2775 A potential DNA crosslinker.
SGTC_1359 1582-0056 520 nM 2.72759805585196 0.0398029505537189 no 308 0.00318986465502984 19 3661189
SGTC_1627 st003713 25.6 µM 2.71497737714988 0.0404859986989222 no 309 0.00331401489856426 24 16195070 YER133W GLC7
SGTC_1647 st011722 22.4 µM 2.70355932890266 0.041112129451158 no 310 0.00343006000506186 24 2854783
SGTC_3221 9128209 49.47 µM 2.6960752855277 0.0415267750343177 no 311 0.00350809035718875 23 16460723
SGTC_1175 0741-0056 27.6 µM 2.68257005879306 0.0422835881992751 no 312 0.00365294237692797 26 765927
SGTC_1253 0550-0034 176 µM 2.67762956884976 0.042563218486757 no 313 0.00370725844157213 33 5969915
SGTC_580 1123-0028 41 µM 2.67081757523448 0.042951225648794 no 314 0.00378333784739375 46 1677248 YPR107C YTH1
SGTC_2289 7946404 165.07 µM 2.66181771332114 0.0434682295036038 no 315 0.00388599776020654 43 1246120 YPR165W RHO1
SGTC_2054 5233173 129 µM 2.66087696499367 0.0435225602784027 no 316 0.00389687151983021 4 6889
SGTC_541 4513-1321 94 µM 2.64633890829419 0.0443691616850336 no 317 0.00406841250531397 31 747515
SGTC_1516 st013856 110 µM 2.64223015370851 0.0446108191544531 no 318 0.00411810334392874 21 5281404 A mutagen and neurotoxin.
SGTC_1287 0971-0001 34.6 µM 2.64192292833701 0.0446289312118851 no 319 0.00412184062684106 28 4665869
SGTC_851 0394-0702 453 µM 2.63318446761722 0.0451465801253198 no 320 0.00422941957702006 48 762646
SGTC_606 k015-0008 38.6 µM 2.62453280748839 0.0456638359259647 no 321 0.00433839665184131 18 1970475
SGTC_1037 k284-1091 78.7 µM 2.61776573203547 0.0460717298900226 no 322 0.00442537726068378 25 3334711
SGTC_2512 diallyl trisulfide 49.23 µM 2.6146259083261 0.0462619781589601 no 323 0.00446626153575696 18 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent
SGTC_1568 digitonin 820 nM 2.60836180624821 0.0466434172673248 no 324 0.00454883690411998 49 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1
SGTC_3006 9075424 71.4286 µM 2.59803475719724 0.047277766624605 no 325 0.00468795015312138 25 7465181
SGTC_1533 dihydroergotamine mesylate 29.4 µM 2.59602546971607 0.0474019889839717 no 326 0.00471545370565207 40 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release.
SGTC_1453 4237-0541 195 µM 2.58798981577707 0.0479014025218734 no 327 0.0048268917414206 36 739892
SGTC_165 k038-0023 64.381 µM 2.58543131563886 0.0480612936844782 no 328 0.00486286240572797 43 46368543
SGTC_2516 gossypol 71.55 µM 2.58477237829407 0.0481025424726841 no 329 0.0048721651946919 29 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_805 3852-0218 479 µM 2.58392333614729 0.0481557333854634 no 330 0.0048841752415988 32 6615355
SGTC_236 1509-0011 5.31 µM 2.57792943822661 0.0485325800604471 no 331 0.00496971460414994 71 3107280
SGTC_2677 mitomycin C 100 µM 2.56839263014304 0.0491370324215007 no 332 0.00510856791256219 12 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_994 3910-0338 138 µM 2.56318702732947 0.0494694966926201 no 333 0.00518580809634107 45 3479481
SGTC_1114 scopoletin 1.73284 µM 2.56225664498713 0.0495291057704814 no 334 0.00519972195939727 16 5280460 A coumarin with genotoxic properties.
SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM 2.56058616981462 0.0496362760370081 no 335 0.00522478729148255 14 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding.
SGTC_2269 7935389 174.42 µM 2.55629185675745 0.0499126294716567 no 336 0.00528971714542628 26 97605
SGTC_1776 st049249 45.9 µM 2.55320141744682 0.050112267869563 no 337 0.00533688756573558 39 1822314
SGTC_352 k048-0007 5.11 µM 2.54136714523198 0.0508826393989014 no 338 0.00552099508222723 44 6811911
SGTC_2095 5432005 200 µM 2.53764043703318 0.0511271782099618 no 339 0.00558012904763034 25 783734
SGTC_1032 k061-1018 98.7 µM 2.5373161179124 0.0511485035136183 no 340 0.0055853017303646 24 4005393
SGTC_354 2783-3500 4.88 µM 2.53468033366638 0.0513220796879743 no 341 0.00562749900267124 65 6740761
SGTC_1052 3253-3998 198 µM 2.53440424765955 0.0513402880548081 no 342 0.00563193530672108 21 5450317
SGTC_1765 st044815 90.4 µM 2.53057056006996 0.0515936580786317 no 343 0.00569385888353124 36 645695
SGTC_454 lyso-paf C-16 6.67 µM 2.52414451958373 0.0520205866650053 no 344 0.00579901189163059 29 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_2759 disulfiram 3.38 µM 2.52236809530565 0.0521391013026557 no 345 0.00582838292021705 46 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_197 4544-0043 41.561 µM 2.51175270433746 0.0528517861888457 no 346 0.00600666200162323 53 896523
SGTC_1567 st069303 68.4 µM 2.51026429095873 0.0529523285225018 no 347 0.00603204161183203 41 5581319
SGTC_2028 5153890 36.43 µM 2.51023955922725 0.0529540004314874 no 348 0.00603246412536492 36 2830968 YPR165W RHO1
SGTC_1874 staurosporine 7.6 µM 2.50928395050519 0.0530186333471847 no 349 0.006048809716049 25 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1
SGTC_1028 k015-0029 4.8 µM 2.50759234841045 0.0531331987938062 no 350 0.00607784066502162 30 4588309
SGTC_2753 fluvastatin 17.09 µM 2.50401520212108 0.053376110960735 no 351 0.00613963790092487 35 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5
SGTC_181 1447-1644 8.07 µM 2.49979605945292 0.0536637492707846 no 352 0.00621324096838905 35 534600
SGTC_326 k292-0812 17.5 µM 2.49603854760641 0.0539209484672096 no 353 0.00627944765048972 26 3579357
SGTC_605 1315-0399 119 µM 2.49167016203307 0.054221187352118 no 354 0.00635720239960264 31 24020461
SGTC_2698 st077697 67.5 µM 2.4830191484909 0.0548196738049747 no 355 0.00651370422748213 29 3154499
SGTC_2417 cerulenin 830 nM 2.48084876433233 0.0549706396914868 no 356 0.00655349853440966 35 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1
SGTC_1057 3448-5381 134 µM 2.47442657715008 0.055419274014455 no 357 0.00667251241205986 50 5497911
SGTC_602 3130-1533 38.1 µM 2.47420836569421 0.0554345682315389 no 358 0.00667658957984047 41 720941
SGTC_3081 9117243 49.47 µM 2.47008961818302 0.0557238725638126 no 359 0.00675396035710761 72 45595589
SGTC_2227 7312221 64.1025 µM 2.4624542475307 0.0562633379616575 no 360 0.00689948885835214 11 887188 YOR168W | YOR169C GLN4 | YOR169C
SGTC_2467 5474540 200 µM 2.45684315298554 0.0566623994967513 no 361 0.00700819337151249 36 5413519
SGTC_2790 5423970 71.43 µM 2.44302054004879 0.0576549786547371 no 362 0.00728245415294972 43 1376240 YKL165C | YIL048W MCD4 | NEO1
SGTC_433 pimozide 108 µM 2.43941938798491 0.0579158038335132 no 363 0.00735544220675871 16 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic
SGTC_1953 st076800 12.1 µM 2.43749655154616 0.0580554508677031 no 364 0.00739467764127854 46 297591
SGTC_852 0418-0143 439 µM 2.43404951109412 0.0583064562590118 no 365 0.00746547630176795 39 5369229
SGTC_3196 9111891 49.47 µM 2.42742946341272 0.0587909024262062 no 366 0.00760312173494412 25 18891510
SGTC_1029 k015-0030 64.7 µM 2.42133868296394 0.0592394024378237 no 367 0.00773173133302012 28 2208316
SGTC_2485 5633444 17.78 µM 2.42076065696767 0.0592821049125345 no 368 0.00774403552020715 31 5724239
SGTC_3356 9151811 4.48 µM 2.42049922054052 0.059301426817788 no 369 0.00774960626063215 26 1859254 YPR165W RHO1
SGTC_1962 st076595 64.5 µM 2.41970316734177 0.0593602908974209 no 370 0.00776659044732788 48 279619
SGTC_1582 3',3',6'-trihydroxyflavone 74 µM 2.41931028645918 0.0593893593161346 no 371 0.00777498482003426 36 688803
SGTC_3277 9138724 49.47 µM 2.41834629516637 0.0594607302592673 no 372 0.00779561548927248 30 15943418
SGTC_1084 voriconazole 435 nM 2.40833161532202 0.0602061694126326 no 373 0.00801280850900708 41 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_1731 st035964 63 µM 2.40558131251473 0.0604121624216575 no 374 0.00807337910521904 44 6739575
SGTC_1311 1190-0148 100 µM 2.4010470374409 0.0607529756074721 no 375 0.00817411745353012 34 1961333
SGTC_391 gliotoxin 8.33 µM 2.40072322093595 0.0607773722853547 no 376 0.00818135378082841 35 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion
SGTC_1419 3993-2473 62.6 µM 2.40071807904329 0.0607777597427701 no 377 0.00818146873208231 23 704026
SGTC_972 1319-0219 195 µM 2.3888142741075 0.0616799381866992 no 378 0.00845142238069673 41 23903702
SGTC_1413 3910-0535 34.4 µM 2.3871641545244 0.0618058201605924 no 379 0.00848945403402607 21 2876951
SGTC_2654 protoveratrine a 100 µM 2.3791934734283 0.0624167021228164 no 380 0.00867528332282493 28 5702278 A heart drug and vasodilator.
SGTC_2906 7926292 26.41 µM 2.37903260231726 0.0624290797606347 no 381 0.00867907032809353 28 2966319
SGTC_1945 st075991 56.6 µM 2.37708432513266 0.0625791347958467 no 382 0.00872504919797558 47 1084980
SGTC_142 0335-0849 62.6745 µM 2.37184510058517 0.0629840511768252 no 383 0.00884975460530164 50 3889043 YPR107C YTH1
SGTC_2626 ethyl orsellinate 100 µM 2.37003380391247 0.0631245120232646 no 384 0.00889322949038461 47 75653 A natural product.
SGTC_1113 artemisinin 1.17947 µM 2.36091581906306 0.0638352934859458 no 385 0.00911493410763305 64 2240 An anti-malaria and mitochondrial poison.
SGTC_1655 st012546 55.1 µM 2.36083481345671 0.063841635962289 no 386 0.00911692526030883 22 720985 YLR208W SEC13
SGTC_2822 7994718 71.43 µM 2.36020040842565 0.0638913247709905 no 387 0.00913253238386736 31 1018011
SGTC_1386 3228-0095 33.8 µM 2.35060537518325 0.0646465139369312 no 388 0.00937144990541202 30 870181
SGTC_2359 9039622 200 µM 2.34238126951738 0.0652993044211946 no 389 0.00958056473932118 23 6463596
SGTC_3274 9138298 49.47 µM 2.34122085799181 0.0653918226173476 no 390 0.00961039655880881 34 17015756
SGTC_2440 5628896 157.78 µM 2.33700817486227 0.0657285494605195 no 391 0.00971937951004437 27 5522048
SGTC_546 peri-Naphthalide 147 µM 2.33655965679718 0.0657644792916155 no 392 0.00973104612020151 70 223824 A penicillin ester.
SGTC_393 acivicin 6.25 µM 2.33541372774763 0.0658563463759665 no 393 0.00976090898657889 39 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1
SGTC_2997 9067075 71.4286 µM 2.33213528195334 0.0661197228593493 no 394 0.00984678774229346 56 27209819
SGTC_2312 7706453 155.7 µM 2.32068918741055 0.0670456544904566 no 395 0.01015181235542 47 976098
SGTC_107 0358-0022 2.6945 µM 2.31605585267398 0.0674233070119891 no 396 0.0102776096631087 22 521106 YGL093W | YPR107C SPC105 | YTH1
SGTC_1250 0485-0349 40.2 µM 2.3124158185127 0.0677211493914324 no 397 0.0103773897332758 34 6842794 YDL195W SEC31
SGTC_674 0498-0004 451 µM 2.3063776092283 0.0682174602460314 no 398 0.0105447709975099 64 4231473
SGTC_3267 9137951 49.47 µM 2.30161400132133 0.0686109824272348 no 399 0.010678474920949 20 16643986
SGTC_1265 0819-1001 68.8 µM 2.30093513691086 0.0686672057429755 no 400 0.0106976488337264 38 3106768
SGTC_373 0844-0104 25.9 µM 2.29083074187369 0.0695082543580146 no 401 0.0109866024451053 57 5375804
SGTC_655 k060-0012 42 µM 2.29002913051146 0.0695753153588149 no 402 0.0110098140145852 49 5994525
SGTC_1802 st050112 57.9 µM 2.28568827692857 0.069939327011176 no 403 0.0111362507860623 28 4662563
SGTC_1532 4',5'-dihydroxyflavone 78.7 µM 2.28202067157742 0.0702480226268326 no 404 0.0112440599253768 43 165521
SGTC_769 0302-0231 76 µM 2.28027174985338 0.070395594643181 no 405 0.0112957881055737 69 571869 YER009W NTF2
SGTC_2795 7780010 54.55 µM 2.26335864845216 0.0718350256564931 no 406 0.0118067948269691 38 953673
SGTC_1341 1486-1360 280 µM 2.25969132014002 0.072150100129101 no 407 0.0119202076928736 35 3976547
SGTC_2651 TUB2.036 5 µM 2.25930479013923 0.0721833700387686 no 408 0.0119322160789869 80 15992207 YFL037W TUB2
SGTC_1381 2324-0066 62.1 µM 2.25754345458659 0.0723351228764145 no 409 0.0119870686947835 41 10885928
SGTC_744 1594-0068 283 µM 2.25673806525 0.0724045948647409 no 410 0.012012223405425 37 668392
SGTC_557 1315-0110 16.2 µM 2.25626121547759 0.0724457514826548 no 411 0.0120271384094949 32 6833801
SGTC_1842 st055362 61.2 µM 2.24775131339887 0.0731832534955446 no 412 0.0122960259856274 21 676032
SGTC_2756 carbadox 75.1 µM 2.24604907188703 0.0733314635898739 no 413 0.0123504324466531 67 2553 A substituted quinoxaline antibiotic. YLR208W SEC13
SGTC_814 3342-0569 96 µM 2.24504432245299 0.0734190524098394 no 414 0.0123826436757762 39 4346283
SGTC_960 1222-0186 7.7 µM 2.24271817579784 0.0736221407850789 no 415 0.0124574969031545 44 3126296
SGTC_3169 9102970 49.47 µM 2.23811677934915 0.0740251386296972 no 416 0.0126067203592836 20 17027839
SGTC_32 0928-0142 34.1 µM 2.23756137229762 0.0740738958621437 no 417 0.0126248364570936 40 2244242
SGTC_2671 danthron 100 µM 2.23378112397751 0.0744064025479594 no 418 0.0127487390681332 60 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin.
SGTC_1301 naphtanilide LB 4.81 µM 2.23185059005832 0.0745766492832918 no 419 0.0128124197115718 55 67238 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_3198 9112019 49.47 µM 2.22299140001832 0.0753617237484878 no 420 0.0131081899403063 42 45595555
SGTC_1784 st039334 36.3 µM 2.22200427876709 0.0754495880395837 no 421 0.0131415082199235 44 3496984
SGTC_1325 1431-0015 227 µM 2.22186594550845 0.0754619074054306 no 422 0.0131461832207534 27 1103340
SGTC_2471 5466956 24.79 µM 2.20867915528523 0.0766433182417882 no 423 0.0135984826470779 64 724419
SGTC_2157 5649910 96.377 µM 2.20575453196877 0.0769072323963054 no 424 0.0137005957161818 43 2858091
SGTC_2265 7929201 200 µM 2.1882899356927 0.0784976140019832 no 425 0.0143242447684095 45 1265108
SGTC_675 1309-0189 238 µM 2.18603313321318 0.0787049314879116 no 426 0.0144065906742834 48 4246530
SGTC_3148 9097893 49.47 µM 2.18143370406008 0.079128734704782 no 427 0.0145756765023663 45 17174100
SGTC_654 1124-0271 80.9 µM 2.18078591855797 0.0791885618933182 no 428 0.0145996272886679 48 5403748
SGTC_1300 1094-0077 113 µM 2.1777616000914 0.079468330587101 no 429 0.0147118950653963 35 5532636
SGTC_1838 st055369 84.5 µM 2.17760991655232 0.0794823819532208 no 430 0.0147175453177592 35 676036
SGTC_363 0455-0021 3.06 µM 2.17501106610231 0.079723421402609 no 431 0.0148146435658252 63 4597466
SGTC_2002 4023503 131 µM 2.17425497425761 0.0797936515117372 no 432 0.0148429959188516 59 4736863 YCR052W RSC6
SGTC_67 0335-0847 266 µM 2.15677171823161 0.0814306755270484 no 433 0.0155117278850255 70 4552207 YOR254C SEC63
SGTC_3317 9138495 8.753 µM 2.153597054925 0.081730629652 no 434 0.0156358927188443 56 17020139
SGTC_2196 6573537 42.6665 µM 2.14779822101102 0.0822806742779222 no 435 0.0158648942084837 39 2903087
SGTC_2747 doxorubicin 7.63 µM 2.14456065777369 0.0825889815336965 no 436 0.0159939953561128 26 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_1911 st060208 74.3 µM 2.13729683472415 0.0832838650318804 no 437 0.0162869280757762 43 688783
SGTC_1390 3413-2614 145 µM 2.1339529197736 0.0836052295834251 no 438 0.0164233174523624 52 3421432
SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM 2.12949103159355 0.0840354860469185 no 439 0.0166068280521201 30 279621
SGTC_3344 9148862 3.898 µM 2.12749359268155 0.0842286353812654 no 440 0.0166895465612274 30 4905352
SGTC_2597 laccaic acid a 100 µM 2.12641293695356 0.0843332719653689 no 441 0.0167344457548117 56 5491415 A textile dye.
SGTC_2648 atorvastatin 78.68 µM 2.11396420562639 0.0855456872790961 no 442 0.0172591623204204 36 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11
SGTC_1161 k007-0610 110 µM 2.11360003066996 0.0855813507380376 no 443 0.0172747216194179 83 5843850
SGTC_1761 st044296 37 µM 2.11253165376579 0.0856860405557763 no 444 0.0173204369575726 50 1826700
SGTC_2816 7982706 58.44 µM 2.10893211493341 0.0860394635982613 no 445 0.017475220834642 57 2981853
SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM 2.10283565867722 0.0866405342975145 no 446 0.0177400688814546 69 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W
SGTC_598 3937-0236 20.2 µM 2.10253601866285 0.0866701575574777 no 447 0.0177531739545384 41 1379313
SGTC_2490 carminic acid 95.39 µM 2.09926338815445 0.0869941920549891 no 448 0.0178968444692543 48 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_1063 disulfiram 1.84 µM 2.09853923240859 0.087066015344136 no 449 0.0179287689990656 50 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_682 0kpi-0099 17 µM 2.07846477943781 0.0890747129105183 no 450 0.018833285807934 98 1714895 YML126C ERG13
SGTC_306 1672-3436 11.6 µM 2.07834356527098 0.089086945775759 no 451 0.0188388632958002 39 6797378
SGTC_360 0957-0399 1.01 µM 2.07261997576698 0.0896659915376686 no 452 0.019103830249439 57 6752301 YPR165W RHO1
SGTC_1773 st048542 73.5835 µM 2.06771236749208 0.0901647102736226 no 453 0.0193335391284899 102 3237138
SGTC_2459 5811157 9.22 µM 2.06596296111533 0.0903429849322333 no 454 0.0194159885237869 41 2870684 YBR192W RIM2
SGTC_368 fentichlor 4.58 µM 2.06486054894988 0.0904554615007955 no 455 0.0194680984112278 49 7329 A pesticide.
SGTC_952 1185-0122 232 µM 2.05965510937439 0.0909879652955981 no 456 0.0197157618920319 45 678600
SGTC_1826 st055655 41.6 µM 2.05805536555952 0.0911520814125961 no 457 0.0197924094808236 41 676168
SGTC_2099 5377090 177.372 µM 2.04259037571697 0.0927499517290027 no 458 0.0205465023163202 56 2243829
SGTC_873 0591-4978 488 µM 2.04061242332981 0.0929558022265166 no 459 0.0206446831761874 52 3305145
SGTC_591 4299-0174 154 µM 2.0394830013452 0.093073495407959 no 460 0.0207009230252301 35 5509088
SGTC_653 0203-0016 55.2 µM 2.03712793989157 0.0933192624678297 no 461 0.0208186113366539 42 295302
SGTC_1985 st071382 65.5 µM 2.03454146239036 0.0935897314732916 no 462 0.0209485162918277 50 6123237
SGTC_244 nsc-207895 1.295 µM 2.02836284188336 0.0942381746062383 no 463 0.0212616147875257 15 42640
SGTC_1432 4049-0298 68.4 µM 2.02320078377398 0.094782466052575 no 464 0.0215262254569337 38 741646
SGTC_1105 epirubicin 18.1 µM 2.02092430731165 0.095023234238265 no 465 0.0216438006159168 65 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_3301 9125354 19.7965 µM 2.01632080631085 0.0955114928497711 no 466 0.0218832203086864 34 41905162
SGTC_385 1494-0393 12.4 µM 2.01592225037245 0.0955538513610503 no 467 0.0219040532685073 46 3090647
SGTC_1785 bathophenanthroline 24 µM 2.01106293250325 0.0960714117499945 no 468 0.0221594049184873 83 72812 An iron chelator.
SGTC_3299 9121982 43.1275 µM 2.00733129530969 0.0964702611683543 no 469 0.0223571995048943 50 17594604 YPL160W CDC60
SGTC_2399 5884133 200 µM 2.00051951055691 0.0972014617677587 no 470 0.0227220976390008 70 722445
SGTC_1243 0416-0003 5.65 µM 1.99915276897766 0.0973486611341441 no 471 0.0227959135410924 60 2141977
SGTC_388 3',4'-dichloroisocoumarin 16.7 µM 1.99682457430687 0.0975997863619605 no 472 0.0229221215239056 54 1609 A potent and irreversible inhibitor of serine proteases.
SGTC_2941 9056145 11.23 µM 1.99534507535073 0.0977596156908757 no 473 0.0230026284477587 51 2119517
SGTC_1783 st039459 87.517 µM 1.99344327406035 0.0979653478105378 no 474 0.0231064646435597 55 729761
SGTC_327 1273-0057 3.96 µM 1.99312788901782 0.0979994960266926 no 475 0.0231237224057431 52 3108138
SGTC_691 1548-0686 185 µM 1.99122240698326 0.0982059970580954 no 476 0.0232282207574182 78 46495133
SGTC_1167 k781-0610 148 µM 1.98246912265112 0.0991587045851116 no 477 0.0237133799607614 65 4525169
SGTC_2320 7373003 200 µM 1.98202495220553 0.0992072276617998 no 478 0.023738224008778 49 5415828
SGTC_139 0099-0334 718.624 µM 1.98163498981469 0.0992498431310257 no 479 0.0237600540436736 51 97690
SGTC_3266 9136860 49.47 µM 1.97824086357832 0.0996213219069915 no 480 0.0239507704251584 70 4871271 YPR165W RHO1
SGTC_1288 0973-0013 65.5 µM 1.97303522400345 0.10019303882948 no 481 0.0242457746728653 40 4315430
SGTC_2066 5222451 176 µM 1.97272557710524 0.100227121565865 no 482 0.0242634181394761 87 2281147
SGTC_1299 1079-1439 3.74 µM 1.96444357977509 0.101141861000349 no 483 0.0247393365841664 55 323161
SGTC_1581 himbacine 57.9 µM 1.95714229991985 0.101953314265392 no 484 0.0251653701956484 50 5281825 An alkaloid muscarinic receptor antagonist.
SGTC_311 1315-0136 58 µM 1.95443127441172 0.102255816566397 no 485 0.0253251175628038 48 6759207
SGTC_398 bronopol 33.3 µM 1.95318484896821 0.102395114374226 no 486 0.0253988478573347 68 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them.
SGTC_778 3456-2434 196 µM 1.95267267386287 0.102452393937382 no 487 0.0254291968307828 51 5539063
SGTC_572 0960-0087 17.7 µM 1.95214029436514 0.102511957767935 no 488 0.0254607752053456 81 6796365
SGTC_1091 telmisartan 47.6 µM 1.94868716776526 0.102898912767763 no 489 0.0256663975811248 50 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension.
SGTC_52 0329-0193 875 nM 1.94032133896507 0.103840779258888 no 490 0.0261703248093181 52 3739292
SGTC_3352 9151559 45.5865 µM 1.93844082687485 0.104053354744568 no 491 0.026284731754691 46 17159339
SGTC_771 0250-0039 27.3 µM 1.93838495268577 0.104059675657404 no 492 0.0262881374248661 59 3005115
SGTC_1621 st003705 32.4 µM 1.93266468040076 0.104708270369787 no 493 0.0266387594314296 58 24207032
SGTC_824 1304-0008 100 µM 1.92908467771719 0.105115676707887 no 494 0.0268601754213704 56 768245
SGTC_493 zm226600 134 µM 1.92526023589101 0.10555216640933 no 495 0.027098404824818 64 5240098 A potassium channel opener. YCR052W RSC6
SGTC_544 k015-0020 52.4 µM 1.91991123305434 0.10616485314949 no 496 0.0274345563966542 62 3008304
SGTC_2128 5255449 168.493 µM 1.90976072213159 0.107334570433234 no 497 0.0280820143304636 62 736008
SGTC_1411 3909-8223 150 µM 1.90897448062286 0.107425560948819 no 498 0.0281326918912505 64 X1411
SGTC_2088 5278280 127.392 µM 1.90581954983286 0.107791235355841 no 499 0.0283368108004381 52 791502
SGTC_332 4112-0506 40.9 µM 1.90327832524242 0.108086429030122 no 500 0.0285021187692842 88 2790355
SGTC_3082 9117008 49.47 µM 1.8962474476269 0.108906181263875 no 501 0.0289636658862882 44 41448529
SGTC_2652 actinonin 100 µM 1.89320269609522 0.109262561910629 no 502 0.0291654595071615 56 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase.
SGTC_2808 7946468 45.46 µM 1.89078529294347 0.109546109090629 no 503 0.029326505601214 67 2970879
SGTC_1067 clotrimazole 1.36 µM 1.87007018784504 0.111997551298332 no 504 0.030737035874763 76 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_1302 1159-0335 255 µM 1.86817443163019 0.112223840227801 no 505 0.0308688807220218 55 649284
SGTC_274 sirtinol 40.1 µM 1.86409272525777 0.112712166129651 no 506 0.031154341983205 74 6836442 NAD-dependent acetyltransferase inhibitor.
SGTC_2465 5809242 33.21 µM 1.8630803190229 0.112833522566901 no 507 0.0312254833797175 53 2731748
SGTC_2451 5856223 45.7 µM 1.85695845622408 0.113569333704333 no 508 0.0316585324096107 84 2179896
SGTC_625 k213-0058 121 µM 1.85392939434741 0.11393467126037 no 509 0.0318746309608985 99 3655420
SGTC_1683 st010134 710 nM 1.85225153714973 0.114137398968142 no 510 0.0319948556493629 54 3818134
SGTC_2940 9060638 45.86 µM 1.85171947902489 0.114201738707766 no 511 0.0320330576953848 55 4027022
SGTC_2349 9023730 187.07 µM 1.84960297542575 0.114457935070232 no 512 0.0321853968310045 45 4126287
SGTC_2016 5121758 140 µM 1.8488990251107 0.114543236729227 no 513 0.0322361972531354 86 2795203
SGTC_868 0527-0199 213 µM 1.84533431698498 0.114975887375894 no 514 0.0324944607069873 55 2849450
SGTC_757 1066-0008 322 µM 1.84164108213362 0.115425361930863 no 515 0.032763833801522 60 6842497
SGTC_1465 k213-0056 144 µM 1.84092924624085 0.115512137211575 no 516 0.0328159639468457 75 24048857 YMR208W ERG12
SGTC_399 oxolinic acid 75 µM 1.837859164306 0.115886921959342 no 517 0.0330415803916736 54 4628 A DNA gyrase inhibitor.
SGTC_1525 8-methoxypsoralen 92.5 µM 1.83523963997465 0.116207386220557 no 518 0.0332350950608595 84 4114 Related to psoralen; DNA damaging agent.
SGTC_304 1310-0298 97 µM 1.83415440831195 0.116340334072377 no 519 0.0333155384546943 66 1550234
SGTC_1676 st018489 23.4 µM 1.81497590182094 0.118707646478731 no 520 0.0347638064486835 56 3696235
SGTC_957 1187-1561 14.1 µM 1.81475547696028 0.118735051159748 no 521 0.0347807476669806 68 1538454
SGTC_692 k241-0027 77.8 µM 1.81285166262856 0.118971932003857 no 522 0.0349273516287536 56 3600480
SGTC_1276 0871-0068 94.2 µM 1.81246327680109 0.119020297610311 no 523 0.0349573216375887 72 3414906
SGTC_1356 1502-0781 85.8 µM 1.80924983851999 0.119420999080618 no 524 0.0352060990249008 65 567702
SGTC_2495 cafestol 54.53 µM 1.80827142524185 0.119543191679603 no 525 0.0352821334501273 87 16667697 An anti-infammatory.
SGTC_3078 9116413 49.47 µM 1.80429810970626 0.120040319491545 no 526 0.0355922929860829 72 17177322
SGTC_3079 9117512 49.47 µM 1.80318758911276 0.120179524235907 no 527 0.0356793794651059 51 7185044
SGTC_442 cape 100 µM 1.79162318870556 0.121635894133515 no 528 0.0365966730311124 45 5281787
SGTC_1230 0170-0365 3.77 µM 1.78836950757247 0.122047875014084 no 529 0.0368582062392825 88 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1
SGTC_1591 genipin 88.4 µM 1.78492500930445 0.122485083890522 no 530 0.0371367407225796 78 442424 A DNA cross-linking agent.
SGTC_1509 1326-1131 80 µM 1.78330733452778 0.122690793566742 no 531 0.0372681440622123 47 768313
SGTC_2322 7413319 38.22 µM 1.77858950420448 0.123292114370688 no 532 0.0376535430541439 92 1840400
SGTC_2464 5717415 7.67 µM 1.77577517160307 0.123651802727765 no 533 0.0378849907874442 51 5285744
SGTC_931 2812-0076 566 µM 1.77505635918064 0.123743788892572 no 534 0.037944290910436 65 3450959
SGTC_2706 st078239 82.5 µM 1.77250863457995 0.124070206068192 no 535 0.0381550816320329 75 15434492
SGTC_2887 9044784 58.44 µM 1.76857890279096 0.124574867951563 no 536 0.0384820870297324 95 6465546
SGTC_2224 6650123 117.647 µM 1.76605977526204 0.124899131785199 no 537 0.0386929104910588 58 2908370
SGTC_2996 9066192 71.4286 µM 1.76370069837986 0.1252033280516 no 538 0.038891191745928 69 6472854
SGTC_3099 9120367 49.47 µM 1.76119923847725 0.125526448904619 no 539 0.0391023434542245 63 24824940
SGTC_1170 0310-0127 64.8 µM 1.75561839598616 0.126249438787967 no 540 0.0395767944918637 80 774975
SGTC_2813 7971799 71.43 µM 1.75219568462762 0.126694279062196 no 541 0.0398700827196488 81 2234054
SGTC_1034 k072-0165 12.7 µM 1.75010541139732 0.126966482285991 no 542 0.0400500630898895 70 5835461
SGTC_2300 7976697 71.57 µM 1.74844335106577 0.127183212341101 no 543 0.0401936434025586 49 2236109
SGTC_2018 5133068 143 µM 1.74779239972531 0.127268165480137 no 544 0.0402499909290194 76 785362
SGTC_2285 7945142 200 µM 1.73876443646665 0.128450441193081 no 545 0.0410381032649552 75 2970608
SGTC_1608 st001473 40.5 µM 1.73736756411276 0.128634050390376 no 546 0.0411611563568798 92 7292267
SGTC_226 1,3-diallylurea 8.28947 mM 1.73644246844795 0.128755748008448 no 547 0.0412428143063095 78 74537 YKL182W FAS1
SGTC_1583 clindamycin 39.6 µM 1.73591272889392 0.128825471936992 no 548 0.0412896333783229 73 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis.
SGTC_2760 etidronate 98.04 µM 1.73009928014171 0.129592354806455 no 549 0.0418062694196892 67 3305 A chelator and antioxidant.
SGTC_1008 4106-0037 6 µM 1.7296956802936 0.129645712951909 no 550 0.0418423304484467 82 2905394
SGTC_1966 st070145 16.1 µM 1.72693469171253 0.1300111391158 no 551 0.042089696562665 78 3748532
SGTC_2533 agelasine 13.65 µM 1.72632947012896 0.130091337414198 no 552 0.0421440782229768 85 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase.
SGTC_2071 5230951 39.92 µM 1.7246090687395 0.130319495864833 no 553 0.0422989740053993 84 1799272
SGTC_1556 plumbagin 1.48 µM 1.72215929113446 0.13064486118797 no 554 0.0425203334816797 87 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_902 1120-0002 2.07 µM 1.71896620935785 0.131069790356983 no 555 0.0428102624668962 85 3280475
SGTC_3122 9126309 49.47 µM 1.71706608577188 0.131323107809431 no 556 0.0429835489552739 80 17591206
SGTC_2248 tofa 1.1 µM 1.71664076133839 0.131379856765815 no 557 0.0430224149964981 92 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_2266 7929956 200 µM 1.71237824000317 0.131949519296625 no 558 0.0434134932387695 71 2967153
SGTC_2072 5231554 129 µM 1.71170136158189 0.132040136887508 no 559 0.0434758587885571 69 789545
SGTC_2849 9019321 12.99 µM 1.70883016169469 0.132424997927483 no 560 0.043741206992562 73 16489627
SGTC_1018 4259-0013 28.1 µM 1.70679561783125 0.132698179544454 no 561 0.043930023614765 72 6801262
SGTC_2241 6772625 37.8075 µM 1.70245546592756 0.133282235541792 no 562 0.0443350100085211 71 2285411
SGTC_2725 haloperidol 53.21 µM 1.70074832473514 0.133512450174604 no 563 0.0444951282617642 96 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_1384 3089-0840 101 µM 1.70007683008597 0.133603078739145 no 564 0.0445582374317144 46 1069836
SGTC_1324 1418-0026 34.4 µM 1.69670062617457 0.134059390536063 no 565 0.0448766371216387 65 1372513
SGTC_1387 3342-1166 1.8 µM 1.69547233537734 0.134225665859674 no 566 0.0449929269733183 50 3418228
SGTC_2690 usnic acid 100 µM 1.68952676763498 0.135032527026895 no 567 0.0455592633183502 74 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_1993 st073995 70.8 µM 1.68834477929826 0.135193327866859 no 568 0.0456725320194321 82 3098394
SGTC_34 0469-0683 81.75 µM 1.68214859864013 0.136038420419518 no 569 0.0462700142640853 73 3690923
SGTC_1162 k048-0130 20.1 µM 1.67706754823949 0.136734114316541 no 570 0.0467646368784362 72 6797406
SGTC_2171 5739187 198.077 µM 1.67665000461843 0.136791392057621 no 571 0.0468054711950895 68 2262761
SGTC_513 4245-1575 41.7 µM 1.67249237366667 0.137362621757399 no 572 0.0472136352303401 117 719745
SGTC_2084 5306078 60.6385 µM 1.67041963107418 0.137648009849455 no 573 0.0474181841447602 82 679340
SGTC_1329 1447-1697 50.6 µM 1.66943521518025 0.137783691990768 no 574 0.0475155797612068 67 2840515
SGTC_924 2046-0044 21.3 µM 1.66707913020981 0.138108801904242 no 575 0.0477493356806722 89 3623589
SGTC_1640 st009078 66.4 µM 1.66672797655191 0.138157301421664 no 576 0.0477842536524484 83 690618
SGTC_251 melphalan 456.522 µM 1.66465735053471 0.138443521643208 no 577 0.0479905682184327 90 460612 A DNA alkylator.
SGTC_2773 thioridazine 9.09 µM 1.66392413099024 0.138544970540159 no 578 0.0480637959974358 68 5452 An antipsychotic.
SGTC_2734 clemastine 41.6 µM 1.66301199417945 0.138671245271093 no 579 0.048155017306434 81 26987 Clemastine is a selective histamine H1 antagonist.
SGTC_738 1315-0003 72.4 µM 1.65755702586161 0.139428058413966 no 580 0.0487034548512963 72 6251474
SGTC_3263 9137018 49.47 µM 1.6567282872728 0.139543281600564 no 581 0.0487872106491908 96 43844957
SGTC_3036 9090181 49.47 µM 1.65070398095863 0.140382813707211 no 582 0.0493995172759238 70 25236586
SGTC_3023 9089636 49.47 µM 1.64980953388536 0.140507753391833 no 583 0.0494909490973633 66 17249241
SGTC_597 k018-0003 82.8 µM 1.64210957887304 0.141586433478192 no 584 0.0502836484504639 63 6786234
SGTC_2991 9074669 71.4286 µM 1.64031948472947 0.141838007878903 no 585 0.0504693781920474 119 17333109
SGTC_229 benomyl 22.8748 µM 1.63927667537544 0.141984700590274 no 586 0.0505778257071083 84 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C
SGTC_485 niflumic acid 177 µM 1.6371529847426 0.142283759091515 no 587 0.0507992539522174 68 4488 A COX2 inhibitor.
SGTC_1942 st076330 65.2 µM 1.63588553089216 0.142462445115164 no 588 0.050931773380525 76 24208414
SGTC_1657 st012939 43.4 µM 1.63325168811261 0.142834250309581 no 589 0.0512080365356628 49 24207257
SGTC_1153 4055-0057 267 µM 1.63195914263084 0.14301695159319 no 590 0.0513440467728486 96 882706
SGTC_929 2805-0021 398 µM 1.63192620776462 0.143021608998095 no 591 0.0513475161492958 79 3098024
SGTC_488 nitrendipine 139 µM 1.62350537296544 0.144215784623759 no 592 0.0522407078607166 62 4507 Dihydropyridine L-type calcium channel blocker.
SGTC_1038 k292-0204 154 µM 1.6219746262144 0.144433582859119 no 593 0.0524043906005486 78 4454212
SGTC_1053 3366-3204 134 µM 1.61607702746381 0.145274778317519 no 594 0.0530388301805235 100 3632071 YPR165W RHO1
SGTC_2705 st078069 42.8 µM 1.61073958467352 0.146038912776588 no 595 0.053618247007891 80 1530061
SGTC_2421 5690543 90.72 µM 1.61022900800138 0.1461121506848 no 596 0.0536739354412833 90 3397993
SGTC_2880 9042983 58.44 µM 1.60627195038436 0.146680593648839 no 597 0.0541070852739444 100 6464714
SGTC_3252 9135871 49.47 µM 1.60574511018161 0.146756387580894 no 598 0.0541649626789868 79 17682838
SGTC_3022 9087993 49.47 µM 1.60389726855844 0.147022435224376 no 599 0.054368349505029 71 17173644
SGTC_759 3486-0358 89.3 µM 1.60121171376783 0.147409670986576 no 600 0.054665017633357 97 875103
SGTC_2981 9013952 38.96 µM 1.60028481196781 0.147543481400997 no 601 0.054767707315824 75 2996344
SGTC_1781 st038725 66.3 µM 1.59866488874725 0.147777533853068 no 602 0.0549475415977937 97 4270275 YIL048W NEO1
SGTC_2135 5326629 150.42 µM 1.58722269834109 0.149437821103577 no 603 0.0562311078338975 75 5020077
SGTC_492 tmb-8 126 µM 1.58644076484241 0.14955173413777 no 604 0.0563196796522877 61 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1
SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM 1.57940806716444 0.150578870136523 no 605 0.0571212440901365 88 688761
SGTC_2765 myclobutanil 7.74 µM 1.57832498230111 0.150737472833788 no 606 0.0572454847377868 102 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11
SGTC_340 k038-0059 454 µM 1.57744931827454 0.150865782926469 no 607 0.0573460875358394 88 23733424
SGTC_1933 st074711 15.9 µM 1.5731469689275 0.151497257366073 no 608 0.0578423956844142 114 17250958
SGTC_2586 curcumin 80 µM 1.57008599482971 0.151947598176642 no 609 0.0581975531778287 95 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40
SGTC_281 1672-3440 14.9 µM 1.56970048977847 0.152004377963044 no 610 0.0582424036167888 82 6833000
SGTC_2782 7736369 71.43 µM 1.5696556107543 0.152010988964396 no 611 0.0582476266974567 99 2950836 YOL077C BRX1
SGTC_2903 5923464 63.88 µM 1.56651941216011 0.152473446444171 no 612 0.0586135338243647 80 2876576
SGTC_1048 3161-0300 24.5 µM 1.56049515026508 0.153364388473421 no 613 0.0593214575712713 64 2165101
SGTC_536 3852-0578 10.6 µM 1.54727603085156 0.155331458575272 no 614 0.0608983494967181 93 2869208
SGTC_1927 st060202 13.8 µM 1.53915805220741 0.156547670082584 no 615 0.0618828577766839 89 688887
SGTC_1451 4152-0210 104 µM 1.53858585941681 0.156633630204273 no 616 0.0619527164339162 88 659563
SGTC_1360 1598-0022 39.8 µM 1.53857165281678 0.156635764847059 no 617 0.061954451691421 114 761525
SGTC_2584 androsterone 48.74 µM 1.53641976848339 0.156959321922572 no 618 0.0622177307084911 110 2754130 A steroid.
SGTC_2541 muurolladie-3-one 83.07 µM 1.52986408431042 0.157947742079711 no 619 0.0630251875179331 141 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils. YMR203W TOM40
SGTC_1121 fusaric acid 630.51 nM 1.52523180491217 0.158648623579635 no 620 0.0636006451660496 86 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler.
SGTC_678 1218-2179 85.9 µM 1.51971020730331 0.159486722343932 no 621 0.0642919125340792 82 6820081 YOR116C RPO31
SGTC_2543 pimpinellin 60.67 µM 1.51423523115957 0.160320601083326 no 622 0.0649830945329744 91 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo.
SGTC_3334 9142812 21.919 µM 1.51416562654428 0.160331220682945 no 623 0.0649919186705633 93 45283678
SGTC_1964 st076914 61 µM 1.51409897667157 0.160341389907338 no 624 0.065000369091798 115 24208661
SGTC_185 k048-0037 25.491 µM 1.51175329510664 0.160699554953889 no 625 0.0652983174868811 71 6827589
SGTC_627 1391-0720 175 µM 1.50630540065588 0.161533415042782 no 626 0.0659943961902652 107 997839
SGTC_1165 k072-0275 30.3 µM 1.50267566707794 0.162090548717032 no 627 0.0664613502161629 98 6153523 YGL055W OLE1
SGTC_777 1315-0167 517 µM 1.50203866397782 0.162188452281236 no 628 0.0665435619043453 83 4221767
SGTC_2178 5812956 200 µM 1.5013073520706 0.162300898011287 no 629 0.066638042137311 84 5403383
SGTC_3294 9122953 26.2835 µM 1.49959844307528 0.162563855821027 no 630 0.066859225621354 93 16459826
SGTC_1058 3448-5425 97.3 µM 1.49910042474242 0.162640540361653 no 631 0.0669237907206697 114 7279705
SGTC_1108 betulinic acid 729.144 nM 1.4985538654693 0.162724726285104 no 632 0.0669947043634654 87 64945 Apoptosis-inducing agent of unknown mechanism.
SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM 1.49784366424778 0.162834160133182 no 633 0.0670869366329672 93 803109
SGTC_983 1491-0821 12.2 µM 1.49707924266993 0.162952002181102 no 634 0.0671863200764454 89 46495113
SGTC_1483 3453-0561 55.9 µM 1.49646219185069 0.163047166212337 no 635 0.0672666266581898 113 4546991
SGTC_2293 7624732 200 µM 1.4929873417007 0.163583745796404 no 636 0.0677202502033051 103 894453
SGTC_246 cycloheximide 667 µM 1.49051275283094 0.163966565210326 no 637 0.0680447329045124 105 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells.
SGTC_2356 9061756 188.97 µM 1.48140185408475 0.1653810284711 no 638 0.0692497604819983 88 20104043
SGTC_2893 9048488 25.97 µM 1.48125655360361 0.165403650078921 no 639 0.0692691105753662 115 6467338
SGTC_1959 st077091 55.8 µM 1.48082116292756 0.165471447368029 no 640 0.0693271177764967 136 821356 YKL052C ASK1
SGTC_2796 7949634 45.45 µM 1.47279443236626 0.166724557455564 no 641 0.0704032370381116 120 2971588
SGTC_1473 k844-0725 134 µM 1.46510843743563 0.167930196493372 no 642 0.071445667521863 117 54682906
SGTC_694 1315-0438 43.2 µM 1.46054833837105 0.168648147688108 no 643 0.0720697163622452 85 6793154
SGTC_1588 farnesol 29.9 µM 1.46049878993907 0.168655959512522 no 644 0.072076519932701 99 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_1166 k206-0078 225 µM 1.45969934767688 0.168782032028062 no 645 0.0721863606359394 112 5404595
SGTC_2726 cimetidine 79.27 µM 1.45703836123739 0.169202107279629 no 646 0.072552895673199 90 2756 A P450 inhibitor, histamine H2-receptor antagonist.
SGTC_2700 st077718 96.8 µM 1.45700962201354 0.169206647843315 no 647 0.0725568620970077 101 904970
SGTC_1348 1493-0373 93.8 µM 1.4566803283831 0.169258679142714 no 648 0.0726023211814094 103 3010129
SGTC_613 3914-0030 117 µM 1.45110447178725 0.170141272810539 no 649 0.0733753857601741 57 1145395
SGTC_213 1246-0773 967 nM 1.45096689705463 0.170163086516439 no 650 0.0733945390878273 82 6251622
SGTC_2354 9060492 162 µM 1.45004715150523 0.170308966446891 no 651 0.0735226854733057 107 6471895
SGTC_2067 5224629 34.075 µM 1.44925654843324 0.170434427228502 no 652 0.0736329753661704 103 2835000
SGTC_1552 6-methylflavone 10.6 µM 1.44450755729595 0.171189289706926 no 653 0.0742981277341558 91 689013
SGTC_170 4197-0004 226 µM 1.44355712009734 0.171340620130265 no 654 0.0744317970419954 114 218692
SGTC_573 3702-0553 84.7 µM 1.44153809294633 0.171662377175317 no 655 0.0747163618198506 112 1222756
SGTC_1065 prochlorperazine maleate 2.48 µM 1.44110905711216 0.171730799057115 no 656 0.0747769375969945 117 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine.
SGTC_760 0568-0725 82.9 µM 1.43820656023691 0.172194141628267 no 657 0.0751877272035622 102 3916171
SGTC_81 0411-0046 9.971 µM 1.43752181542251 0.172303567648116 no 658 0.0752848893321015 156 12925265
SGTC_3110 9122132 49.47 µM 1.43600670611095 0.172545848168334 no 659 0.0755002165180049 87 918317
SGTC_1353 1498-1206 8.11 µM 1.43539201796137 0.172644204620387 no 660 0.0755877096430849 99 6756808
SGTC_977 1348-1378 135 µM 1.434639159311 0.172764718470146 no 661 0.075694974826369 109 X977
SGTC_2762 leflunomide 42.06 µM 1.43262669168065 0.173087127395283 no 662 0.075982274803737 126 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1
SGTC_1884 5633444 25 µM 1.42920170498729 0.173636710548846 no 663 0.076473133904521 105 5724239
SGTC_169 k015-0017 16.025 µM 1.42815199163406 0.173805372603467 no 664 0.0766240577168094 108 1840002
SGTC_2476 5806916 10.51 µM 1.42668791467991 0.174040786234677 no 665 0.076834935334777 95 2870194
SGTC_1459 k035-0031 35.7 µM 1.41940773455814 0.17521439790926 no 666 0.0778900893885931 89 3877128 YMR208W ERG12
SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM 1.41908593305227 0.175266389942561 no 667 0.0779369822566851 115 688788
SGTC_2567 aureobasidin a 60 nM 1.41661704042857 0.175665603306156 no 668 0.0782974618335125 165 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1
SGTC_3145 9085516 49.47 µM 1.41527992659175 0.175882051372402 no 669 0.0784932190508991 107 25236195
SGTC_2129 girgensonine 121.053 µM 1.41335678186618 0.176193660433518 no 670 0.0787754231092567 134 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_1198 1612-1005 86.7 µM 1.40458590372109 0.177619241494966 no 671 0.0800722253692913 129 6998509
SGTC_2155 5570423 76 µM 1.40374406981869 0.177756451376856 no 672 0.0801975371114267 108 797402
SGTC_1562 morin hydrate 59.1 µM 1.40223511640927 0.178002561869546 no 673 0.0804225242508899 112 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase.
SGTC_2484 5809818 12.04 µM 1.39904652652247 0.178523327588605 no 674 0.0808995157051616 101 2870548
SGTC_925 2064-1272 59.6 µM 1.39625726505869 0.17897966037789 no 675 0.0813185188797232 116 6815817
SGTC_2315 7733312 200 µM 1.39570709323739 0.179069756977456 no 676 0.0814013587100497 107 726316
SGTC_362 0310-0100 9.03 µM 1.39493361414379 0.179196470810743 no 677 0.0815179297284192 95 790235
SGTC_137 0438-0332 85.389 µM 1.39406491382237 0.179338851313248 no 678 0.0816490015735726 148 2063393 YER012W | YPR107C PRE1 | YTH1
SGTC_1836 st055642 81 µM 1.38432937292056 0.180939374986172 no 679 0.0831288119970046 126 8571
SGTC_1247 0448-0043 5.84 µM 1.38427003709428 0.180949157164673 no 680 0.0831378925210664 127 3089013 YGL099W LSG1
SGTC_768 0384-0033 77.3 µM 1.3809891158271 0.181490569678651 no 681 0.0836411536301316 117 3965305 YMR134W ERG29
SGTC_2197 6588183 93.1375 µM 1.37774330162385 0.182027185559506 no 682 0.0841412784974616 87 884136
SGTC_3181 9108277 49.47 µM 1.37718740998277 0.182119188026281 no 683 0.0842271566499651 120 17097298
SGTC_3276 9139060 49.47 µM 1.37710225165851 0.182133284663862 no 684 0.0842403183314067 147 4870619
SGTC_3031 9088762 49.47 µM 1.37505568967225 0.182472266346941 no 685 0.0845570900995867 110 205253
SGTC_3121 9125696 49.47 µM 1.37228294762196 0.182932156856411 no 686 0.0849876860032615 89 1235365
SGTC_1570 verbenone 133 µM 1.37007257864216 0.183299289119966 no 687 0.0853321233327758 111 29025 A natural terpanoid with antifungal properties.
SGTC_2532 xanthone 78.9 µM 1.36045532751923 0.184902013594538 no 688 0.0868429401501791 85 7020 An insecticide.
SGTC_2301 7769476 200 µM 1.35805021127095 0.185304185874083 no 689 0.0872238760591227 119 977820
SGTC_1467 k284-1082 293 µM 1.35691981794229 0.18549339243706 no 690 0.0874033445508249 113 3334705
SGTC_1155 4088-0394 48.2 µM 1.35523783486217 0.185775146595388 no 691 0.0876708969561969 123 2326248
SGTC_2907 7721985 69.9 µM 1.35204285756094 0.186311077649682 no 692 0.0881808027495239 110 3267881
SGTC_1728 st035614 33.7865 µM 1.35078524876848 0.186522293609605 no 693 0.0883821173705065 138 15945546
SGTC_1805 st050013 60.3 µM 1.34823295894932 0.186951407467682 no 694 0.0887917335126596 117 4037144
SGTC_3239 9133757 49.47 µM 1.34414024816083 0.187640784560702 no 695 0.0894515195930324 99 17036923
SGTC_2694 st077685 81.9 µM 1.34334405070143 0.187775078489777 no 696 0.0895802972368351 99 2838096
SGTC_2767 sibutramine 71.45 µM 1.34238116531327 0.187937566809547 no 697 0.0897362192388513 97 64765 A serotonin-norepinephrine reuptake inhibitor.
SGTC_2768 sulfasalazine 50.2 µM 1.34188973118075 0.188020530489431 no 698 0.0898158758958947 110 5384001 An antioxidant and salicylic acid derivative.
SGTC_1769 st044406 64.4 µM 1.3418072542039 0.188034456429216 no 699 0.0898292497546745 154 670903
SGTC_982 1491-0518 27.5 µM 1.34126892597369 0.1881253668467 no 700 0.0899165774556467 103 3091256
SGTC_1218 1348-1416 30.7 µM 1.33821282257351 0.188641981618416 no 701 0.0904135351775532 119 6787668
SGTC_1690 st023502 41.2 µM 1.33553978836204 0.189094557272108 no 702 0.0908498709590827 131 24207482
SGTC_2792 7535235 81.82 µM 1.33413754179102 0.189332241042835 no 703 0.0910793921414178 130 1281891
SGTC_669 0108-0021 26.2 µM 1.32878436343304 0.190241306092248 no 704 0.0919595612029954 117 17201
SGTC_2272 7805186 180 µM 1.3286638282834 0.190261805928782 no 705 0.0919794518379255 127 2956062 YPR165W RHO1
SGTC_2258 7960471 200 µM 1.32847378963722 0.190294129225517 no 706 0.09201081836728 101 2974708
SGTC_914 3820-6779 408 µM 1.32311296763374 0.191207330032982 no 707 0.0928989064531488 106 2893481
SGTC_1894 3',6'-dihydroxyflavone 78.7 µM 1.32272251414638 0.191273947477444 no 708 0.0929638367701491 130 688662
SGTC_1943 st076331 65.2 µM 1.31922701309449 0.191870967981474 no 709 0.0935466149829061 113 24208415
SGTC_1131 3454-3128 32.3 µM 1.31806501561419 0.192069685839986 no 710 0.0937409422383815 123 710982
SGTC_3237 9133362 49.47 µM 1.31794928535531 0.192089484230219 no 711 0.0937603127554561 121 43845137
SGTC_2598 perillyl alcohol 100 µM 1.31686975485712 0.192274223527194 no 712 0.0939411430662999 108 10819 An apoptosis inducer.
SGTC_2142 5622915 118.518 µM 1.31503822509942 0.192587900409173 no 713 0.0942485280396963 95 5322196
SGTC_2936 9038235 15.59 µM 1.31499186972592 0.192595843516838 no 714 0.0942563174596578 129 4749415
SGTC_614 0462-0418 107 µM 1.31431798716896 0.192711337568551 no 715 0.0943696083246467 111 5188303
SGTC_3064 1327-0027 10 µM 1.31129090348303 0.193230659231401 no 716 0.0948797502348469 87 16000455 YPR107C YTH1
SGTC_2431 5490079 200 µM 1.31109899968364 0.193263610708654 no 717 0.0949121593452647 149 5722345
SGTC_551 k048-0028 34.9 µM 1.3076981093646 0.193848140612403 no 718 0.0954878624350697 139 6836383
SGTC_2600 tangeritin 87.95 µM 1.30694938712051 0.193976972248071 no 719 0.0956149507033765 147 68077 A bioactive flavone.
SGTC_429 1112-0049 25.5 µM 1.30599685604291 0.194140948386701 no 720 0.0957768133667426 119 2836170
SGTC_662 k832-1615 104 µM 1.30469984967496 0.19436436090372 no 721 0.0959975363507059 111 5878478
SGTC_3019 9081971 49.47 µM 1.30271100544981 0.194707248072399 no 722 0.0963367216687081 111 16451803
SGTC_2418 pentamidine 31.67 µM 1.29852283829821 0.19543051248852 no 723 0.0970538668229555 137 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_140 0062-0056 502.533 µM 1.29599701065552 0.195867491378799 no 724 0.0974882573927375 110 3758964
SGTC_2728 chlorpromazine 9.18 µM 1.29598373207161 0.195869790195665 no 725 0.0974905447987977 114 2726 A thorazine and dopamine antagonist.
SGTC_815 1582-0027 36.9 µM 1.29104809040481 0.19672539269309 no 726 0.0983435011803655 135 3128206
SGTC_2290 7904846 200 µM 1.28829359628356 0.197203871886588 no 727 0.0988218907104226 125 2962154
SGTC_1916 st067606 49.2 µM 1.28604926518167 0.197594251480226 no 728 0.0992129343892157 147 19590279
SGTC_1607 st000305 50.6 µM 1.28584968292716 0.19762898947793 no 729 0.099247763546802 122 5457690
SGTC_1124 fisetin 1.16336 µM 1.28496876623328 0.197782360244602 no 730 0.0994015993950488 125 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster.
SGTC_2636 apigenin dimethyl ether 100 µM 1.28416830249995 0.197921786208593 no 731 0.0995415367070347 130 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_1696 st025591 34.7925 µM 1.28218163582688 0.198268083203784 no 732 0.0998894683551388 108 2787147
SGTC_853 0419-0306 21 µM 1.28023503026112 0.19860775160383 no 733 0.100231244703492 149 762713
SGTC_2403 6032726 181.2 µM 1.27871853155709 0.198872612563269 no 734 0.100498095739183 113 2881040
SGTC_1418 3966-3099 2.4 µM 1.27570379515636 0.199399777064598 no 735 0.101030123252099 146 740335
SGTC_921 1561-0023 372 µM 1.27256658458851 0.199949250023906 no 736 0.101585941201396 143 24050882
SGTC_1747 st037496 66.6 µM 1.26979962280237 0.200434629849811 no 737 0.102078007564043 157 723305
SGTC_447 ml7 120 µM 1.26872452120647 0.200623414690009 no 738 0.102269666772011 104 4216 Selective myosin light chain kinase inhibitor.
SGTC_2956 9076196 2.52 µM 1.2673159699149 0.200870913861519 no 739 0.102521166233381 134 16423868
SGTC_61 0978-8327 98.565 µM 1.26466002314434 0.201338093363671 no 740 0.102996613183604 122 6150059 YHR072W ERG7
SGTC_1579 chlormadinone acetate 49.4 µM 1.26309409158214 0.20161384477018 no 741 0.103277683561483 132 45114258 A steroidal progestin.
SGTC_2580 diallyl disulphide 81.36 µM 1.26295269892919 0.201638754322368 no 742 0.103303089633764 136 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.
SGTC_2786 7743617 45.45 µM 1.26247101440037 0.201723627914475 no 743 0.103389674950743 116 583674
SGTC_1816 st051957 91.6 µM 1.26156838641229 0.20188273002502 no 744 0.103552068892082 113 674121
SGTC_2553 4-methylesculetin 85.09 µM 1.26129241025025 0.201931390074332 no 745 0.103601757348274 121 5319502
SGTC_854 0422-0053 192 µM 1.25929867944409 0.202283132729534 no 746 0.103961235022715 145 3596728
SGTC_1232 0279-0259 161 µM 1.2547688783473 0.203083660946066 no 747 0.104781336685569 138 1560000
SGTC_2147 5545932 89.7195 µM 1.24779965433982 0.204318982865471 no 748 0.106052217658438 157 797404
SGTC_574 1315-0397 40 µM 1.24660330770264 0.204531488945954 no 749 0.106271494150805 157 6794277
SGTC_2721 ifenprodil 61.44 µM 1.24526742414298 0.20476893622214 no 750 0.106516732902855 132 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor.
SGTC_1136 pergolide 1.05886 µM 1.24404763068764 0.204985892140331 no 751 0.106741016687345 155 47811 A dopamine receptor agonist.
SGTC_1920 st075728 45.7 µM 1.24260587763798 0.205242502551421 no 752 0.107006551473395 124 3400306
SGTC_3124 9127567 49.47 µM 1.24211551721595 0.20532982282503 no 753 0.107096972071524 120 17592030
SGTC_2159 5658611 73.75 µM 1.24142304600266 0.205453171284081 no 754 0.107224754963987 127 793844
SGTC_400 oxethazaine 37.5 µM 1.24132080059247 0.205471387774135 no 755 0.107243631794041 134 4621 A local anesthetic.
SGTC_2656 pseudo-anisatin 100 µM 1.24130758711453 0.205473742015211 no 756 0.107246071477661 130 6708809 A neurotoxin.
SGTC_3092 9117248 49.47 µM 1.2400628304104 0.205695591731962 no 757 0.107476077841964 145 17141857
SGTC_2391 6285546 200 µM 1.23598038476372 0.206424192327238 no 758 0.108232927474214 121 846083
SGTC_1099 5-nonyloxytryptamine 2.85 µM 1.23515698516222 0.206571330863405 no 759 0.108386042297575 130 23581825 A 5-HT1D beta serotonin receptor agonist.
SGTC_1237 0330-0133 46.1 µM 1.23029964298882 0.207440583698549 no 760 0.109292458983777 153 X1237 YHR072W ERG7
SGTC_917 harmaline 728.087 nM 1.22779540862187 0.2078895760946 no 761 0.109761889839067 136 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7
SGTC_985 1493-0307 8.71 µM 1.22590150717679 0.20822952069146 no 762 0.110117870786163 136 3278274
SGTC_2146 5545642 200 µM 1.22393933050229 0.208582066011607 no 763 0.11048755760627 134 825326
SGTC_3103 9120822 49.47 µM 1.22324229576827 0.208707387266514 no 764 0.110619097408053 168 17141819
SGTC_3325 9138760 55.175 µM 1.22252725566723 0.208835991842864 no 765 0.110754151653587 123 43844959
SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM 1.2210155392096 0.209108037459725 no 766 0.11104006816528 133 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1
SGTC_2 0422-0095 29 µM 1.22095492018968 0.209118950693044 no 767 0.111051544277825 126 6790840
SGTC_1228 0124-0032 52.5 µM 1.21956257163419 0.209369707302334 no 768 0.111315371126417 114 X1228
SGTC_3228 9131799 49.47 µM 1.21650011040673 0.209921866969019 no 769 0.111897234505467 144 17015818
SGTC_2944 9067346 25.62 µM 1.21579915769752 0.210048368517824 no 770 0.112030719882066 153 6473075
SGTC_3192 9110362 49.47 µM 1.21243770271397 0.210655635340839 no 771 0.112672437974414 125 16649480
SGTC_2477 5967686 25.23 µM 1.21133037522672 0.210855905958813 no 772 0.112884405853797 135 776118
SGTC_1455 4262-0120 131 µM 1.20818685005464 0.211425050172117 no 773 0.113487699360646 133 1529587
SGTC_302 1094-0063 18.9 µM 1.20565528649682 0.211884050312414 no 774 0.113975216161967 171 5440289
SGTC_630 4356-0227 183 µM 1.20482751665643 0.212034260407861 no 775 0.114134947490459 178 779312
SGTC_1003 4049-0218 100 µM 1.20475907265779 0.21204668328911 no 776 0.114148161979712 161 295161
SGTC_3279 9140807 49.47 µM 1.2045754137357 0.212080020279731 no 777 0.114183626410236 136 45595718
SGTC_1614 st002383 48.6 µM 1.20129563651628 0.21267586742059 no 778 0.114818271231951 111 1947235
SGTC_687 k029-0044 34.9 µM 1.19927941452347 0.213042645283785 no 779 0.115209658375897 103 5829338
SGTC_740 k014-0057 261 µM 1.19696951948509 0.213463299453831 no 780 0.115659217693601 156 4012779
SGTC_620 0109-0052 432 µM 1.1961043337445 0.213620982655302 no 781 0.115827923327468 149 493037
SGTC_3107 9121808 49.47 µM 1.19453194095407 0.213907730549977 no 782 0.116134977010222 118 662681
SGTC_1821 st053465 65.6 µM 1.19446335133081 0.213920243929317 no 783 0.116148384190599 127 675086
SGTC_3028 9087778 49.47 µM 1.19340681644577 0.214113050272645 no 784 0.116355043347321 143 17217395
SGTC_3208 9114115 49.47 µM 1.18886363863094 0.21494328328739 no 785 0.117246665339541 166 650895
SGTC_2947 9072639 7.68 µM 1.18705384275735 0.215274530490412 no 786 0.117603191592864 149 16488146
SGTC_2287 7945887 168.79 µM 1.18622445102532 0.215426433116138 no 787 0.117766836327383 150 1245853
SGTC_2311 7694451 200 µM 1.18587936455563 0.21548965382082 no 788 0.11783497172911 179 2163142
SGTC_396 dithiazanine 1.25 µM 1.18487063764028 0.21567451680793 no 789 0.118034299163657 122 10578 An antihelmenthic.
SGTC_2897 9048598 12.99 µM 1.18448632647097 0.215744971260322 no 790 0.118110302898179 115 6467404
SGTC_3166 9102297 49.47 µM 1.1818175131655 0.216234603557063 no 791 0.118639058619353 142 25237072
SGTC_2073 5212005 126 µM 1.18101406171198 0.216382134221364 no 792 0.118798568618466 151 691789
SGTC_2423 st077119 87.2 µM 1.17330259908345 0.217801081711334 no 793 0.120337240192705 138 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae).
SGTC_1719 st032227 49.2 µM 1.17198657972161 0.218043770830665 no 794 0.120601222122157 136 3125804
SGTC_2952 9073731 13.78 µM 1.17123243739488 0.218182913590503 no 795 0.120752680093228 147 16457353
SGTC_2979 9012552 45.46 µM 1.16819260896267 0.218744294603158 no 796 0.121364540566192 156 17100905
SGTC_2491 paeonol 100 µM 1.16567739227214 0.219209420627041 no 797 0.121872452031953 131 11092 Increases levels of cortical cytochrome oxidase.
SGTC_2815 7968870 71.43 µM 1.16365599192109 0.219583639459475 no 798 0.122281725299581 143 2977326 YHR190W ERG9
SGTC_1732 st034308 51.822 µM 1.16096121337699 0.22008308993501 no 799 0.122828836589168 148 830119
SGTC_2614 arthonioic acid 13.39 µM 1.1595243307445 0.22034966802883 no 800 0.123121262418297 132 6710684
SGTC_1740 st038286 13.222 µM 1.15896781259417 0.220452965938912 no 801 0.123234652681955 145 716786
SGTC_1527 coumarin 137 µM 1.157093619763 0.22080104758824 no 802 0.123617056552399 164 323 A hepatotoxic, DNA x-linker.
SGTC_3161 9100388 49.47 µM 1.15465032988041 0.221255296152272 no 803 0.12411682368841 161 25236368
SGTC_969 1313-0238 134 µM 1.15362316628383 0.221446422570839 no 804 0.12432734821403 188 5212874
SGTC_984 1492-0255 2.91 µM 1.15358252296957 0.2214539870958 no 805 0.12433568348526 153 1585198
SGTC_2797 7859098 81.82 µM 1.14508026732086 0.223039669857689 no 806 0.126087954386096 158 972681
SGTC_1409 3909-8004 61.9 µM 1.14460219287308 0.223129023017609 no 807 0.126186991752519 144 2119279
SGTC_801 0866-0028 10.1 µM 1.14305678469799 0.223418002571344 no 808 0.126507507655114 142 6849771
SGTC_875 0709-0210 25.7 µM 1.14147045398197 0.22371485567559 no 809 0.126837100244213 161 6251364
SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM 1.13972871485339 0.224041048775554 no 810 0.127199670110778 149 23847180
SGTC_3240 9133527 49.47 µM 1.13886005983287 0.224203831508621 no 811 0.127380763287559 139 17617455
SGTC_312 4092-0653 6.84 µM 1.13863238448576 0.224246508131105 no 812 0.127428257634216 181 1148278
SGTC_672 1441-0018 53.7 µM 1.13634841203695 0.224674882653067 no 813 0.127905388514605 135 251141
SGTC_2163 5671233 125 µM 1.13260886364612 0.225377261397969 no 814 0.128689272378186 159 701023
SGTC_353 1988-1175 58.3 µM 1.12879451241549 0.226094968990363 no 815 0.129492264058963 160 2788357
SGTC_116 0155-0182 31.788 µM 1.12774278998424 0.226293087827703 no 816 0.129714280383829 147 771486
SGTC_3159 9100096 49.47 µM 1.12484988518234 0.226838546053571 no 817 0.130326325646559 125 25236875
SGTC_1868 st057644 42.7 µM 1.12328243195877 0.22713439945047 no 818 0.130658781327227 142 688665
SGTC_3204 9114183 49.47 µM 1.1228364851021 0.227218610680881 no 819 0.130753473371298 148 17027248
SGTC_1941 st076221 61.8 µM 1.11969695238066 0.227811968130752 no 820 0.131421462098643 156 2828568
SGTC_417 st075190 100 µM 1.11951714787559 0.227845976746161 no 821 0.131459789752616 177 222757
SGTC_3065 9113888 49.47 µM 1.11885775258679 0.227970720652098 no 822 0.131600414416519 150 16648368
SGTC_1853 st056710 91.2 µM 1.11782480834041 0.228166209476858 no 823 0.131820911917915 168 269167
SGTC_1749 st037932 54.2 µM 1.11560005202675 0.228587573441346 no 824 0.132296684922104 164 594497
SGTC_954 1189-0853 2.85 µM 1.11447652899128 0.228800532216034 no 825 0.132537404066912 153 2828194
SGTC_127 0180-0333 59.125 µM 1.1136974731591 0.228948264133134 no 826 0.13270449685323 123 771601
SGTC_1895 st058434 18.3 µM 1.1132286846087 0.229037186029482 no 827 0.132805113052347 179 5393175
SGTC_1480 1070-0044 41.2 µM 1.11257724785228 0.229160785612984 no 828 0.132945018284883 154 3124987
SGTC_1843 st055809 45.5 µM 1.10954019538105 0.229737510641597 no 829 0.133598607183015 149 16413835
SGTC_813 k007-0158 173 µM 1.10497415915152 0.230606111693709 no 830 0.134585393182264 162 6523916
SGTC_2733 amorolfine 100 µM 1.10270533291454 0.231038394006094 no 831 0.135077575061643 178 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_2735 sertaconazole 140 nM 1.10055636234683 0.231448256819166 no 832 0.135544893285159 174 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C
SGTC_1947 st076332 61.6 µM 1.09983634119618 0.231585673607763 no 833 0.135701717582367 173 24208416
SGTC_384 k007-0144 5.16 µM 1.09927065452991 0.231693667390161 no 834 0.135825014184739 182 6824886
SGTC_2323 6148992 148.28 µM 1.09826294365696 0.231886116375834 no 835 0.136044844028855 148 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42
SGTC_1330 1469-0054 61.8 µM 1.09773504660062 0.231986967775356 no 836 0.136160100735021 157 7102664
SGTC_1006 4099-6547 255 µM 1.09575672716851 0.232365130390254 no 837 0.136592625126513 166 3146833
SGTC_1898 st060199 18.6 µM 1.08990015116431 0.233486642871986 no 838 0.137878565011396 146 688866
SGTC_1342 1486-1464 234 µM 1.08869827613853 0.233717168194016 no 839 0.138143481126046 168 3253938
SGTC_1079 idarubicin 2.36 µM 1.08810273323407 0.233831442874731 no 840 0.138274878625287 189 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_3171 9103192 49.47 µM 1.08807027558315 0.233837671842427 no 841 0.138282042360605 160 13018434
SGTC_1126 isoteolin 1.0172 µM 1.08523223259557 0.234382677805535 no 842 0.138909405823434 158 133323
SGTC_3286 9117135 37.221 µM 1.08434831964689 0.234552564215801 no 843 0.139105194340946 171 3438150
SGTC_3127 9126946 49.47 µM 1.08249283159043 0.234909406996815 no 844 0.13951679946934 151 27243249
SGTC_679 0422-0091 41.4 µM 1.08219223426434 0.234967245341917 no 845 0.139583559220419 186 627384 YHR062C RPP1
SGTC_949 1165-0505 146 µM 1.07972857752959 0.23544157732327 no 846 0.140131532109144 163 6244267
SGTC_2325 6158266 200 µM 1.07915525496509 0.235552035828309 no 847 0.140259261327546 147 3623240
SGTC_1464 k208-0027 110 µM 1.07334767503459 0.236672556384793 no 848 0.141557576016378 179 X1464
SGTC_2251 lansoprazole 556 µM 1.07314144888001 0.23671239971135 no 849 0.141603828165323 153 3883 Gastric proton pump inhibitor. YBR192W RIM2
SGTC_389 tpck 16.7 µM 1.07277952024799 0.236782334002108 no 850 0.141685025823793 142 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.
SGTC_766 1391-0721 126 µM 1.07160596605543 0.23700917418901 no 851 0.141948526261908 191 1020919 YIL115C NUP159
SGTC_1139 k015-0024 46.9 µM 1.07130640672451 0.237067096135725 no 852 0.142015840029453 163 2766652
SGTC_3218 9131285 49.47 µM 1.07047312025715 0.237228258961714 no 853 0.142203200893159 176 17156417
SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM 1.06774835696902 0.23775566514598 no 854 0.142817019503683 153 4330530
SGTC_1127 asiatic acid 681.4 nM 1.06758851872974 0.237786623452742 no 855 0.14285308244637 165 470603 A kinase inhibitor which arrests cells at G2/M.
SGTC_1062 mesoridazine 14.2 µM 1.06660218579118 0.237977710487843 no 856 0.143075756529213 151 4078 A neuroleptic.
SGTC_2210 7115885 190.385 µM 1.06640594148626 0.23801573988139 no 857 0.143120088510636 160 2927039
SGTC_1897 st060201 15 µM 1.06504929400428 0.238278730226065 no 858 0.143426811691006 167 611878
SGTC_2069 5228469 200 µM 1.06337993886753 0.238602558243172 no 859 0.143804843291929 175 2835210
SGTC_3066 9117245 49.47 µM 1.06224483854771 0.238822886925214 no 860 0.144062274543552 151 17176980
SGTC_301 4119-0100 24.5 µM 1.06129518014637 0.239007305864667 no 861 0.144277887738366 174 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1
SGTC_356 1634-0012 32.5 µM 1.06087154091067 0.239089599603607 no 862 0.144374142144738 189 735457
SGTC_358 0075-0058 9.45 µM 1.05986764590982 0.239284672335543 no 863 0.144602408312072 167 1069125
SGTC_1956 st077085 54 µM 1.05859554012242 0.239531987529855 no 864 0.144892009452321 195 24208685
SGTC_3324 9138759 60.749 µM 1.05830393822546 0.239588698680619 no 865 0.144958449037921 155 45595710
SGTC_512 prima-1 270 µM 1.05540730356382 0.240152438120653 no 866 0.14561954201195 148 322968 A re-activator of the apoptotic function of mutant p53.
SGTC_2123 5259487 200 µM 1.05297268402177 0.240626819404106 no 867 0.146176755807625 166 2173474
SGTC_2714 st079313 56.9 µM 1.05204822449632 0.240807082228756 no 868 0.146388712423664 147 2939799
SGTC_1743 st037606 46.3785 µM 1.05175907063939 0.240863480190996 no 869 0.146455050878964 139 590142 YLR208W | YDL195W SEC13 | SEC31
SGTC_1957 st077035 62.4 µM 1.05115570005745 0.240981187636122 no 870 0.146593542762806 163 705593
SGTC_3151 9099821 49.47 µM 1.04960427185049 0.241283988749419 no 871 0.14695004611013 174 17174189
SGTC_2473 5854593 8.94 µM 1.04945161104502 0.2413137956011 no 872 0.146985157498032 187 2872951
SGTC_2313 7726885 200 µM 1.04773352151986 0.241649388588208 no 873 0.147380699311749 174 726423
SGTC_2489 cantharidin 73.42 µM 1.04548496613548 0.242088979538412 no 874 0.147899442670922 167 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_3101 9120531 49.47 µM 1.04243335059914 0.242686261072238 no 875 0.148605405476581 177 24824904
SGTC_2496 diffractaic acid 79.83 µM 1.04074543512709 0.24301697294097 no 876 0.148996855104687 174 94870 An apoptosis inducer which activates caspases.
SGTC_1016 4226-1401 38 µM 1.04021317354844 0.243121309037744 no 877 0.149120436243414 180 2901613
SGTC_752 1896-0090 130 µM 1.03702143367395 0.243747474796406 no 878 0.149862934119979 192 772567
SGTC_995 3931-2021 34.6 µM 1.03452886147024 0.244237080358544 no 879 0.150444495707191 165 730143
SGTC_1498 4478-3555 97.6 µM 1.03320356506907 0.244497618535379 no 880 0.150754322438749 148 3437919
SGTC_3291 9121177 71.43 µM 1.02683906143578 0.245750890817357 no 881 0.152248126401854 161 17015612
SGTC_1129 3453-1384 223 µM 1.02432869957169 0.246246167957998 no 882 0.152840023336665 180 1084452
SGTC_1960 st011366 51.8 µM 1.02279255689179 0.246549502086875 no 883 0.153202968984147 202 3972846
SGTC_427 1354-0053 47.3 µM 1.02097851365196 0.246907969410028 no 884 0.15363230931498 165 6813657
SGTC_468 gf-109203x 121 µM 1.01743846999757 0.247608308717911 no 885 0.15447244453067 142 2396 A protein kinase C inhibitor.
SGTC_465 cgp-37157 41 µM 1.01692330186914 0.247710314615135 no 886 0.154594958652084 159 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange.
SGTC_2256 7954252 200 µM 1.01586863266159 0.247919214434305 no 887 0.154845973862506 178 2972920
SGTC_2329 6138490 200 µM 1.01499511693911 0.248092304086173 no 888 0.155054077591072 177 720019
SGTC_200 k038-0079 37.545 µM 1.01455199700974 0.248180134213573 no 889 0.155159715705201 199 3436683
SGTC_1497 4476-2978 41.3 µM 1.01359991025826 0.24836890195924 no 890 0.155386850262239 166 1528379
SGTC_2802 7925815 54.55 µM 1.01218764114301 0.248649049755912 no 891 0.15572417212602 171 1262923
SGTC_3077 9117319 49.47 µM 1.0117794768248 0.24873004748697 no 892 0.155821752456307 190 17154678
SGTC_726 3448-4391 34.2 µM 1.01084976859505 0.248914594878704 no 893 0.156044169376622 184 1356692
SGTC_90 0870-0863 4.608 µM 1.00804407053114 0.249471968404897 no 894 0.156716652881054 205 1738164
SGTC_1103 duloxetine 36.1 µM 1.00644424355442 0.249790083018142 no 895 0.157100959928279 186 60835 A selective serotonin reuptake inhibitor.
SGTC_2168 5727979 200 µM 1.00497389833816 0.250082640895083 no 896 0.157454709271852 174 695210
SGTC_754 3474-0146 171 µM 1.0043089558536 0.250215005655735 no 897 0.157614859102082 175 24762078
SGTC_59 0330-0160 1.33 µM 1.00273708651637 0.250528052723485 no 898 0.157993865501982 166 4293482
SGTC_2653 dihydrofissinolide 100 µM 1.00192106403146 0.25069065021629 no 899 0.158190859170551 176 6857746
SGTC_3236 9132701 49.47 µM 1.00085590440055 0.250902973875471 no 900 0.158448238754057 181 24282524
SGTC_789 1309-1135 70.6 µM 1.00070743029889 0.250932577526132 no 901 0.158484137057531 171 3092424
SGTC_1463 k081-0032 34.1 µM 1.00003535729012 0.251066602564472 no 902 0.158646698653598 169 977755
SGTC_379 3970-0972 5.9 µM 0.998362357675516 0.251400397148947 no 903 0.159051839898372 182 2898042 YBL034C STU1
SGTC_1632 st005650 90 µM 0.996686039272877 0.251735089008582 no 904 0.159458464109057 179 2759605
SGTC_962 1254-0300 21.5 µM 0.993728977295744 0.252326065831575 no 905 0.160177415644635 170 7340576
SGTC_1860 st056228 74.6 µM 0.991785345973554 0.252714903792234 no 906 0.160651123783611 201 688679
SGTC_2697 mebhydrolin 72.4 µM 0.9911236310799 0.252847356762827 no 907 0.160812607652398 175 22530 H1 Histamine receptor antagonist. YIL048W NEO1
SGTC_1196 1588-0294 184 µM 0.989355585159273 0.253201439023417 no 908 0.161244598516275 186 6144269
SGTC_2074 5212007 75.395 µM 0.989329369836223 0.253206691063591 no 909 0.161251009458717 182 758611
SGTC_1539 benzyladenosine 56 µM 0.989252202061298 0.253222151371678 no 910 0.161269881759572 187 92208 A nucleotide analog.
SGTC_1644 st010134 20.9 µM 0.988220693334518 0.253428858383682 no 911 0.161522287879434 198 3818134
SGTC_650 1328-0195 38 µM 0.983500750578724 0.254375831405002 no 912 0.162680523036998 193 2780821
SGTC_1024 4507-0395 26 µM 0.982808809433952 0.254514812863993 no 913 0.162850772655889 176 4201836
SGTC_788 1182-0090 188 µM 0.981486477783573 0.254780523503989 no 914 0.163176449732022 183 5715185
SGTC_1022 4477-0945 21.3 µM 0.979952634557216 0.255088917320524 no 915 0.163554749839816 167 4648966
SGTC_1147 3809-1045 12.3 µM 0.979341148023355 0.255211916936868 no 916 0.163705722744835 174 325925
SGTC_70 0141-0289 43.283 µM 0.978707096494853 0.255339488209828 no 917 0.163862362337213 193 352408
SGTC_1394 3474-0001 65.7 µM 0.977829042862829 0.255516207770255 no 918 0.164079442116708 146 5017666 YIL048W NEO1
SGTC_1368 1852-0141 284 µM 0.976048751818835 0.255874710202868 no 919 0.164520152879677 185 2838987
SGTC_2529 gangaleoidin 93.61 µM 0.973861787746592 0.256315464614125 no 920 0.165062584569749 194 4565183
SGTC_19 0279-0214 38.434 µM 0.973610174712069 0.256366199348504 no 921 0.165125066219903 195 3566274 YBR002C RER2
SGTC_1192 1488-0095 21.4 µM 0.97276516722506 0.256536623213047 no 922 0.165335014209497 186 915875
SGTC_3130 9127414 49.47 µM 0.972607414457072 0.256568445841214 no 923 0.165374228106702 187 1494646
SGTC_1730 st033808 45.1 µM 0.971323432259268 0.256827533201921 no 924 0.165693621863972 182 1045166
SGTC_1255 0566-0045 221 µM 0.968994932881516 0.257297734808418 no 925 0.166273858683039 194 2788469
SGTC_3030 9087619 49.47 µM 0.96850074021449 0.257397586300045 no 926 0.166397174753278 205 25236973
SGTC_2640 pentamidine 10.38 µM 0.96737784883979 0.257624541019217 no 927 0.166677589696655 197 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_646 4092-0839 27.3 µM 0.965218723540759 0.258061227383578 no 928 0.167217635377148 212 877796
SGTC_806 3966-4455 5.86 µM 0.964121964479028 0.258283195498035 no 929 0.167492390937069 173 714982
SGTC_729 4092-0585 94.1 µM 0.962470832331524 0.258617547196107 no 930 0.167906573961704 185 2169061
SGTC_1148 3909-7663 27.7 µM 0.961648685066929 0.258784114277336 no 931 0.168113053538969 179 4084526
SGTC_594 1487-1584 10.8 µM 0.961587070128764 0.258796599703177 no 932 0.168128534506053 197 5013332
SGTC_2864 9034755 47.6 µM 0.960906410060248 0.258934546911478 no 933 0.168299613744859 183 4930451
SGTC_1430 4049-0248 69.1 µM 0.960023051889102 0.259113630995955 no 934 0.16852180665358 209 22774488
SGTC_2925 9010536 32.5 µM 0.959412230045819 0.259237500957361 no 935 0.168675558178504 170 2994177
SGTC_2806 7952793 58.44 µM 0.95920152796447 0.25928023681362 no 936 0.168728615444546 189 2972490
SGTC_796 1234-0020 70.7 µM 0.957631639856794 0.25959876548699 no 937 0.169124269372985 179 46495034
SGTC_999 SEC7.066 22.7 µM 0.95717761238444 0.259690924841267 no 938 0.169238807455379 212 740511 YDR170C SEC7
SGTC_1729 st035615 45.989 µM 0.95159173760415 0.260826136583434 no 939 0.170652036724503 197 17385451
SGTC_1526 st051518 75 µM 0.950438101176622 0.261060906619264 no 940 0.170944845899315 175 673993
SGTC_1923 st058458 19.1 µM 0.949776451935 0.261195604123431 no 941 0.171112926749638 224 3534982
SGTC_2007 4011539 71.82 µM 0.945951106802168 0.26197506134547 no 942 0.172086762354368 164 45595301
SGTC_2780 5215298 71.43 µM 0.944965399105378 0.262176103472486 no 943 0.172338270572519 218 2834131
SGTC_441 propafenone 146 µM 0.941785622570836 0.262825180009153 no 944 0.173151203774965 221 4932 Slows the influx of sodium ions into the cardiac muscle.
SGTC_3097 9117246 49.47 µM 0.940801315125984 0.263026269643836 no 945 0.173403343413989 188 16423892
SGTC_2409 alverine citrate 63.97 µM 0.937465540606171 0.263708337865213 no 946 0.17425957063465 155 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_2937 9044753 11.33 µM 0.935742059637812 0.264061092391721 no 947 0.174703004848127 183 6465530 YGL099W LSG1
SGTC_2525 harmine 47.85 µM 0.933178916048911 0.264586149677065 no 948 0.175363799401022 180 5280953 A monoamine oxidase inhibitor
SGTC_448 monastrol 171 µM 0.932464391398233 0.264732613913978 no 949 0.175548290430684 226 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity
SGTC_2371 9071574 200 µM 0.925607595193689 0.266140222295432 no 950 0.177324972408313 210 45596039
SGTC_844 0330-0132 15.3 µM 0.92202625454691 0.266876927212918 no 951 0.17825744058566 207 2828079
SGTC_1362 1611-0397 101 µM 0.918887217439851 0.26752349362742 no 952 0.179077283275939 208 27816
SGTC_2838 9002687 71.43 µM 0.917882534712139 0.267730600919039 no 953 0.179340183122143 211 6457060
SGTC_1315 1237-0019 3.69 µM 0.917141369553191 0.267883437945117 no 954 0.179534282611443 198 825140
SGTC_626 0214-0009 33 µM 0.916527083343147 0.268010144326497 no 955 0.179695254528986 216 3437874
SGTC_3227 9130768 49.47 µM 0.916483748803009 0.268019083909556 no 956 0.179706613642661 198 17720899
SGTC_2724 maprotiline 69.64 µM 0.910524620051059 0.269249834419905 no 957 0.181272951879874 207 4011 A tricyclic antidepressant.
SGTC_883 0850-0245 24.6 µM 0.908679231920914 0.269631540060969 no 958 0.18175973491631 224 6823229 YPR165W RHO1
SGTC_1479 0549-0158 134 µM 0.906860638309383 0.270007968477853 no 959 0.182240249248409 197 5440202
SGTC_730 1436-0052 41.2 µM 0.906526545558681 0.270077150500476 no 960 0.182328610494623 183 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2
SGTC_2199 6590217 200 µM 0.90620250692799 0.270144259044068 no 961 0.182414338184687 186 703109
SGTC_1156 4092-0367 4.88 µM 0.90579053982228 0.27022958965466 no 962 0.182523364591911 229 1357585
SGTC_1930 st074634 34.3 µM 0.904023594685856 0.270595729226363 no 963 0.182991445174394 204 684253 YOR116C RPO31
SGTC_1873 rapamycin 2 nM 0.901605905392666 0.271097114657559 no 964 0.1836331264409 191 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1
SGTC_2635 hydroquinidine 100 µM 0.897891944231293 0.271868225083011 no 965 0.184621579918614 184 442912 An experimental heart treatment.
SGTC_1389 3405-0187 19 µM 0.894386144897517 0.272597115782627 no 966 0.185557661470813 214 799890
SGTC_1244 0416-0015 52.5 µM 0.893033553666135 0.272878592109001 no 967 0.185919602127446 197 96201
SGTC_1296 1068-0102 11.9 µM 0.892454317536025 0.272999176110217 no 968 0.186074734041772 198 767053
SGTC_1262 0737-0114 49.6 µM 0.89183127745953 0.27312890859556 no 969 0.186241687139808 217 765919
SGTC_3051 9093778 49.47 µM 0.890859415600334 0.273331335455812 no 970 0.186502297617395 237 17217378
SGTC_17 0960-0276 49.807 µM 0.885610160611102 0.274425973413507 no 971 0.187913817231886 215 6821114
SGTC_3292 9120825 59.784 µM 0.883967015253833 0.274769065990489 no 972 0.188357009462231 218 24824900
SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM 0.882924104616668 0.274986937812632 no 973 0.188638639475788 244 16725076
SGTC_1090 efavirenz 20.7 µM 0.879437321137821 0.275715970300522 no 974 0.189582101939681 207 64139 A non-nucleoside reverse transcriptase inhibitor.
SGTC_562 3772-2733 112 µM 0.87913424032096 0.275779384661126 no 975 0.189664247205645 203 2876874 YIL048W NEO1
SGTC_3173 9105693 49.47 µM 0.877008795301223 0.276224298138387 no 976 0.190240930428741 209 17096658
SGTC_3140 9094243 49.47 µM 0.875463486715213 0.276547994268112 no 977 0.190660884544753 247 19291112
SGTC_446 go6976 132 µM 0.874521960594721 0.276745307075952 no 978 0.190917033060554 219 3501 A protein kinase C inhibitor.
SGTC_474 dl-dihydrosphingosine 5 µM 0.873290427304167 0.277003499882019 no 979 0.191252398460557 207 3058739 A sphingolipid protein kinase C inhibitor.
SGTC_1210 3013-0140 750 nM 0.873263458962966 0.277009155154392 no 980 0.191259746391631 205 905973
SGTC_2715 st079500 56.4 µM 0.868672231690348 0.277972760394809 no 981 0.192513216922611 232 28246688
SGTC_111 0083-0039 52.457 µM 0.868196454782791 0.278072709753131 no 982 0.192643397354138 183 759313
SGTC_2611 pyromycin 23.93 µM 0.865445003581867 0.278651067517674 no 983 0.193397294585657 204 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release.
SGTC_3278 9139605 49.47 µM 0.864383651622044 0.278874321193415 no 984 0.193688585323101 236 7958859
SGTC_224 benfluorex 43.875 µM 0.863788497667628 0.278999548943553 no 985 0.193852043835256 234 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis.
SGTC_2004 4023728 41.89 µM 0.861699252695469 0.279439368319084 no 986 0.19442651847065 251 360084 YDR527W RBA50
SGTC_1310 1188-0297 994 nM 0.861276158990449 0.279528477274437 no 987 0.19454298158532 204 1588352
SGTC_295 k015-0027 31 µM 0.85944463294089 0.27991437918495 no 988 0.195047627099263 199 3887424
SGTC_3033 9090887 49.47 µM 0.857709953743604 0.280280113555433 no 989 0.195526321176682 210 19325384
SGTC_1377 2944-0135 198 µM 0.856973558759679 0.280435442739122 no 990 0.195729748875832 202 1894137
SGTC_2848 9016370 25.97 µM 0.856505331106645 0.280534228549748 no 991 0.195859162652463 208 7894410
SGTC_900 1112-0045 141 µM 0.855475150940465 0.28075163333868 no 992 0.196144077624824 207 56211 YIL048W NEO1
SGTC_258 haloperidol 50.781 µM 0.852361626227001 0.281409193014258 no 993 0.197006705813163 248 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_1995 st072814 61.1 µM 0.851912821769402 0.28150403935403 no 994 0.197131239944629 202 5769371
SGTC_2000 st075254 36.4 µM 0.851833259993699 0.281520854840739 no 995 0.197153321692975 212 17234175
SGTC_151 3013-0144 2.285 µM 0.849630820065334 0.281986535695605 no 996 0.197765185666385 242 906558 YHR107C CDC12
SGTC_1641 st009299 47.1 µM 0.848659997504892 0.282191922828573 no 997 0.198035255672099 220 4046054
SGTC_1518 st038567 90.8 µM 0.847631125286085 0.282409669503242 no 998 0.19832171728933 249 77966
SGTC_2850 9015429 58.44 µM 0.846218348601216 0.282708795893233 no 999 0.198715473914249 242 6457570
SGTC_1252 0493-0875 34.8 µM 0.846016053418164 0.282751640192555 no 1000 0.198771894395784 195 3960963
SGTC_2020 4017018 200 µM 0.841276773925765 0.283756268501206 no 1001 0.20009644956232 224 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope.
SGTC_3335 9143315 29.6265 µM 0.839734592501652 0.28408354696358 no 1002 0.200528606903754 215 4899691
SGTC_2911 7942208 15.64 µM 0.838978267131013 0.284244118686491 no 1003 0.200740752649766 206 1243384
SGTC_2189 6047310 154.431 µM 0.833779943018682 0.285348921659369 no 1004 0.202202499820199 224 711535
SGTC_3027 9089541 49.47 µM 0.83267940535064 0.285583081676893 no 1005 0.202512781253469 227 9943819
SGTC_800 3448-7362 155 µM 0.830123302510629 0.286127293055937 no 1006 0.203234536672366 250 15991913
SGTC_2275 7947463 200 µM 0.82722562314131 0.286744823529168 no 1007 0.204054595560658 235 1225414
SGTC_659 k018-0002 107 µM 0.825500877287033 0.287112687411895 no 1008 0.204543642416495 229 6797879 YHR007C ERG11
SGTC_2585 alliin 100 µM 0.824199104979927 0.287390484909918 no 1009 0.204913217757112 225 87310 A garlic compound which reacts with lipids.
SGTC_95 0471-0001 561.058 µM 0.822316437248762 0.287792469931996 no 1010 0.205448412023794 230 4015405
SGTC_366 0181-0206 4.31 µM 0.8218927747746 0.287882966447659 no 1011 0.205568962741653 214 274874
SGTC_2009 4012297 12.05 µM 0.821624581442685 0.28794026088834 no 1012 0.205645297311336 208 45595307
SGTC_42 0133-0086 60.653 µM 0.818033076668154 0.288708036352682 no 1013 0.206669150256461 269 162923 Model of phenazepam hydroxylation.
SGTC_577 r071-0003 38.6 µM 0.816753629088458 0.288981783510259 no 1014 0.207034618424149 257 4568517 YMR134W ERG29
SGTC_1461 k072-0203 53.8 µM 0.816507913397973 0.2890343701523 no 1015 0.207104849697103 235 5418714
SGTC_91 0417-1751 58.384 µM 0.813222264340297 0.289737977775736 no 1016 0.208045318288726 245 6795624
SGTC_2022 5136654 200 µM 0.812685525197249 0.289852994485891 no 1017 0.208199191145271 246 1713771
SGTC_1486 3970-0793 4.53 µM 0.81080347738092 0.290256463695393 no 1018 0.208739268606387 247 2844330
SGTC_2282 7944268 200 µM 0.809085790457431 0.29062492703599 no 1019 0.20923290051852 235 2970414
SGTC_2785 7756463 72.73 µM 0.808744093839767 0.290698250924623 no 1020 0.209331179780063 285 2201551
SGTC_2236 dapsone 200 µM 0.808234682877589 0.290807580308954 no 1021 0.20947774770898 222 2955 A bacterial DFR inhibitor. An anti-cancer agent.
SGTC_247 mechlorethamine 29.705 µM 0.805047440900508 0.291492059711111 no 1022 0.210396151961025 215 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links.
SGTC_210 3551-0445 56.827 µM 0.804823157673127 0.291540254170072 no 1023 0.210460868106184 235 2865180 YOR207C RET1
SGTC_1839 st053978 48 µM 0.802956703720117 0.291941465837481 no 1024 0.210999879943841 227 3788398
SGTC_1378 2093-0007 380 nM 0.802710989173416 0.291994303615723 no 1025 0.211070899896172 256 3618014
SGTC_1879 gemcitabine 100 µM 0.801129938900702 0.292334394753823 no 1026 0.211528212800622 243 60750 A nucleoside analog which inhibits DNA replication.
SGTC_978 1416-0512 87.4 µM 0.801053502280162 0.292350841287248 no 1027 0.211550336499958 237 6814003
SGTC_1313 1220-0047 237 µM 0.800428345923134 0.292485369594485 no 1028 0.211731331650239 235 3528706
SGTC_506 n9-isopropylolomoucine 153 µM 0.800004632577588 0.292576565443118 no 1029 0.211854056567289 226 6610355
SGTC_1275 0867-0008 21.1 µM 0.799846769170255 0.29261054577158 no 1030 0.211899790981081 224 3422836
SGTC_1810 st050138 53 µM 0.7988860494179 0.292817381620439 no 1031 0.212178244422829 265 3444541
SGTC_1857 st056007 79.3 µM 0.795882941975306 0.293464365716604 no 1032 0.21305003842392 220 619834
SGTC_188 3229-0966 278.469 µM 0.79549732075529 0.293547491211876 no 1033 0.213162134425861 249 5722370
SGTC_2990 9074105 71.4286 µM 0.795263459654581 0.293597908218784 no 1034 0.213230132122782 247 6502001
SGTC_47 0149-0135 24.25 µM 0.790606915056602 0.294602624187316 no 1035 0.214586705162907 239 5239155
SGTC_1833 st055984 71 µM 0.790562233171632 0.294612272620664 no 1036 0.214599746415947 218 676288
SGTC_1307 1187-1599 12.2 µM 0.789928852335972 0.294749058104196 no 1037 0.214784660134289 257 1538471
SGTC_2446 5162541 200 µM 0.788508750636977 0.295055850903721 no 1038 0.215199591052336 239 1549321
SGTC_880 0833-0487 87.2 µM 0.788132941936094 0.295137063640641 no 1039 0.215309474125137 253 76075
SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM 0.787385114902761 0.295298700623831 no 1040 0.215528228828676 237 689007
SGTC_3087 9117406 49.47 µM 0.786724189156015 0.295441588475331 no 1041 0.21572167038765 229 42546093
SGTC_9 0092-0002 10.449 µM 0.785946848651505 0.295609685127523 no 1042 0.215949313286304 254 759368
SGTC_3308 9128332 17.569 µM 0.785587625286502 0.295687380537256 no 1043 0.216054558265839 223 17332805 YDL196W YDL196W
SGTC_1701 st028638 40.4 µM 0.784031778468258 0.296023998559045 no 1044 0.216510731915648 232 3490878
SGTC_547 1120-0019 610 nM 0.779476965917182 0.297010472986409 no 1045 0.217849400543774 230 3676939
SGTC_1910 st062352 60.4 µM 0.774361424540649 0.298120178388816 no 1046 0.219358544466384 241 2245730
SGTC_2366 9070441 60.58 µM 0.773650528831203 0.298274541114309 no 1047 0.219568741336839 227 6837235
SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM 0.773614031980013 0.298282466962618 no 1048 0.219579535807231 230 17037758
SGTC_1036 k216-0215 33.5 µM 0.769324964677646 0.299214570374037 no 1049 0.2208502103053 215 622330
SGTC_402 epigallocatechin gallate 10 µM 0.764079253870944 0.300356365511802 no 1050 0.222410007306757 262 65064 An antioxidant.
SGTC_2949 9072542 2.23 µM 0.762932347746754 0.300606266153852 no 1051 0.222751871703996 254 16457352
SGTC_1271 0832-2808 169 µM 0.762925001757003 0.300607867082177 no 1052 0.222754062326907 267 3663794
SGTC_1615 st002656 86.5 µM 0.762364643912928 0.300729998490626 no 1053 0.222921200939781 232 1584458
SGTC_313 3474-0040 5.03 µM 0.758065891852691 0.301667666155501 no 1054 0.22420576868547 259 1043375 YIL048W NEO1
SGTC_3084 9116877 49.47 µM 0.757982218904915 0.301685930401762 no 1055 0.22423081375425 247 27241325
SGTC_2587 piperic acid 92.2 µM 0.756009607740684 0.302116658642276 no 1056 0.224821717654784 240 5370536
SGTC_877 0771-0151 33.1 µM 0.754904720153752 0.302358036226478 no 1057 0.225153076714228 233 6166523
SGTC_538 2922-0838 53.3 µM 0.754105861752413 0.302532611474069 no 1058 0.225392828952245 235 777039
SGTC_2026 5148700 152 µM 0.753195029783462 0.302731711513837 no 1059 0.225666362804404 251 79838
SGTC_2075 5212009 200 µM 0.752091479563548 0.302973016707506 no 1060 0.225998023765202 260 780898
SGTC_418 lividomycin a 100 µM 0.751509739755479 0.30310025610272 no 1061 0.226172970694175 240 72394 An antibiotic.
SGTC_1189 1431-2119 7.28 µM 0.748102937010521 0.303845878763123 no 1062 0.227199035309387 269 3107275
SGTC_611 3453-1652 23.7 µM 0.747993285348511 0.303869891027597 no 1063 0.227232103840563 272 1560575
SGTC_3220 9131269 49.47 µM 0.745937372677592 0.304320265335417 no 1064 0.227852623903741 273 17722206
SGTC_3060 1327-0027 12.5 µM 0.744569396398257 0.3046201028454 no 1065 0.228266037231832 240 16000455 YPR107C YTH1
SGTC_1892 st058411 7.36 µM 0.74289687507441 0.304986869949088 no 1066 0.228772058888303 264 3934738
SGTC_1675 st018485 24.5 µM 0.74174550317288 0.30523946815447 no 1067 0.229120772342317 277 3323024
SGTC_2083 5306046 65.942 µM 0.739743537794817 0.305678898001182 no 1068 0.229727812432415 262 539837
SGTC_1089 terbinafine 2.25 µM 0.738519929718344 0.305947616936617 no 1069 0.230099280457764 251 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_2154 5570129 200 µM 0.73340868973877 0.307071234752715 no 1070 0.231654600388165 286 673366
SGTC_1305 1181-0477 144 µM 0.729393569424439 0.307955162691884 no 1071 0.232880475126642 281 6252086
SGTC_1064 honokiol 6.76 µM 0.72825214495669 0.308206650902282 no 1072 0.233229625380808 266 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis.
SGTC_1503 4585-0012 61.3 µM 0.727039237750599 0.3084739874894 no 1073 0.233600959674621 252 2922052
SGTC_1913 st060213 96.1 µM 0.724768208873894 0.308974817499795 no 1074 0.234297121064048 272 688959
SGTC_3258 9138477 49.47 µM 0.723279028685088 0.309303419379234 no 1075 0.234754237143226 268 4970355
SGTC_1777 st045864 34.765 µM 0.723028247789021 0.309358771604894 no 1076 0.234831264874788 294 4691462
SGTC_2892 9047358 58.44 µM 0.720511127709373 0.30991458847105 no 1077 0.235605175426539 253 6466771
SGTC_2185 6113692 200 µM 0.719638642232789 0.310107347533243 no 1078 0.235873756693857 279 874150
SGTC_1990 st072050 59.8 µM 0.719213036422071 0.310201395981685 no 1079 0.236004834132725 266 17233948
SGTC_499 genistein 192 µM 0.718483384290014 0.310362660097212 no 1080 0.236229644665397 289 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger.
SGTC_2957 9076800 11.52 µM 0.716520708037547 0.310796622017159 no 1081 0.236834942757916 274 16459615
SGTC_2727 riluzole 51.77 µM 0.715108292818556 0.311109080218881 no 1082 0.237271065039344 280 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.
SGTC_774 k060-0086 136 µM 0.715073607258672 0.311116755163641 no 1083 0.237281780711872 261 5911235
SGTC_3229 9132204 49.47 µM 0.713377986888315 0.311492048646826 no 1084 0.237805945500276 255 17682924
SGTC_2596 sinensetin 100 µM 0.711529092895183 0.311901489670755 no 1085 0.238378214563568 270 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets.
SGTC_10 0279-0212 42.575 µM 0.707897528308576 0.312706383086254 no 1086 0.239504447381085 262 39851 YBR002C RER2
SGTC_1718 roemerine 11.9335 µM 0.707471708820217 0.312800819576071 no 1087 0.239636693962841 250 235224 An aporphine alkaloid with mutagenic activity.
SGTC_741 4582-0002 126 µM 0.706444145058162 0.313028759023139 no 1088 0.239955988084521 275 2912688
SGTC_2761 levamisole 97.89 µM 0.704563147701941 0.313446196615195 no 1089 0.240541069564182 260 26879 An alkaline phosphatase inhibitor.
SGTC_3088 9117578 49.47 µM 0.70269275649038 0.313861517527846 no 1090 0.241123621381192 278 678341
SGTC_1422 4031-0024 15.5 µM 0.700453645126693 0.314359023148377 no 1091 0.241822022241372 288 782427
SGTC_2558 carylophyllene oxide 100 µM 0.700358353542469 0.314380203368531 no 1092 0.2418517689557 290 6708694 An oxygenated terpenoid and antifungal agent.
SGTC_3307 9126885 69.2785 µM 0.699128881350405 0.314653529835803 no 1093 0.242235745363893 257 24824909
SGTC_948 3448-0295 75.3 µM 0.697665235957309 0.314979048282883 no 1094 0.242693286887534 268 678569
SGTC_637 1181-0519 7.26 µM 0.69535835698767 0.315492395821304 no 1095 0.243415375458535 268 6252091 YGR060W ERG25
SGTC_110 0850-0284 111.64 µM 0.693148480818642 0.315984491611852 no 1096 0.244108187832151 249 3906265
SGTC_3163 9099914 49.47 µM 0.692002427515523 0.316239823581574 no 1097 0.244467902262264 303 16268368
SGTC_1357 1503-1303 39.5 µM 0.69175085182842 0.316295884469275 no 1098 0.244546903120028 255 292895
SGTC_2576 guaiol 23.12 µM 0.690898691181805 0.316485810509748 no 1099 0.244814604349321 259 227829
SGTC_1981 st071826 47 µM 0.684976943856597 0.317806959749319 no 1100 0.246679235088479 258 11838600
SGTC_2172 5754775 163.918 µM 0.684477134984459 0.317918574261865 no 1101 0.2468369614546 267 2263357
SGTC_3201 9113999 49.47 µM 0.683970119554858 0.318031815005502 no 1102 0.246997017159666 269 16649224
SGTC_2139 5578692 56.4705 µM 0.681432653257988 0.318598807827366 no 1103 0.24779888361006 271 650991 YMR113W FOL3
SGTC_1102 cgs 12066b 26.1 µM 0.681430877408821 0.318599204787025 no 1104 0.247799445283624 270 6438352 A 5-HT1B full agonist.
SGTC_3015 9080845 49.47 µM 0.680590868388797 0.318786997274279 no 1105 0.248065203298554 269 5296973
SGTC_343 4130-2827 29.8 µM 0.680177626943264 0.318879398649483 no 1106 0.248195998419509 259 1118244
SGTC_908 3448-7491 47.7 µM 0.67738047283239 0.31950514208037 no 1107 0.249082292293676 240 1203031
SGTC_92 0063-0024 660.874 µM 0.677029856276328 0.31958361382673 no 1108 0.249193505733922 285 3594437
SGTC_2858 9025781 8.96 µM 0.675890523071396 0.319838664583574 no 1109 0.249555077558114 266 4894980 YPL153C RAD53
SGTC_282 k297-0036 65.7 µM 0.674227968199507 0.32021099642608 no 1110 0.250083195529383 285 5061378
SGTC_2474 5321570 43.32 µM 0.674035586673679 0.320254092276269 no 1111 0.250144344629944 283 2841384
SGTC_2615 purpurogallin-4-carboxylic acid 100 µM 0.673753234357011 0.320317347091125 no 1112 0.250234105601689 265 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase.
SGTC_45 0kpi-0036 14.9 µM 0.670710689311276 0.32099929321107 no 1113 0.251202425959214 288 2795021
SGTC_3071 9117417 49.47 µM 0.664370183307965 0.322422373232095 no 1114 0.253226705788822 287 45595590 YGL055W OLE1
SGTC_520 3584-0023 682 µM 0.663381170208161 0.322644585437725 no 1115 0.253543231211871 262 1340790
SGTC_2508 celastrol 40.54 µM 0.660362879656653 0.323323128679045 no 1116 0.254510493668951 248 122724 Celastrol is a natural product and antioxidant.
SGTC_2503 beta-caryophyllene alcohol 24.72 µM 0.659272677703663 0.323568362163431 no 1117 0.25486034207124 297 61125 An anti-inflammatory.
SGTC_3011 9081274 71.4286 µM 0.658283730272059 0.323790885438266 no 1118 0.255177915244848 284 6625322
SGTC_2866 9034245 58.44 µM 0.656926041989719 0.324096481780356 no 1119 0.255614236183383 273 6462273
SGTC_3123 9126162 49.47 µM 0.656510706772858 0.324189991529451 no 1120 0.255747790451332 267 25239884
SGTC_830 4076-0286 57.8 µM 0.655707661795882 0.324370822804096 no 1121 0.256006119083949 283 6866659
SGTC_458 nppb 133 µM 0.655217053034126 0.324481319455127 no 1122 0.256164008201816 283 4549 A chloride channel blocker.
SGTC_1500 4488-1866 171 µM 0.654489753398376 0.324645152901136 no 1123 0.256398163253671 309 2900003
SGTC_2809 7964133 12.99 µM 0.654031079594734 0.324748492430571 no 1124 0.256545891203506 299 1253665
SGTC_60 0986-0278 202 µM 0.652721213614715 0.325043680403472 no 1125 0.256968011922453 313 3110598
SGTC_2569 tetrandrine 100 µM 0.652439219984183 0.325107244127936 no 1126 0.257058935148365 266 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_292 k038-0015 474 µM 0.65114627840563 0.325398749130448 no 1127 0.257476032531681 289 46368540
SGTC_1963 st076565 50.3 µM 0.650284657206584 0.325593068517189 no 1128 0.257754182902242 305 4914280
SGTC_1543 azetidyl-2-carboxylic acid 198 µM 0.649160508303852 0.325846666425518 no 1129 0.258117317375902 284 16486 A toxic proline analog.
SGTC_2407 paclitaxel 400 µM 0.641327874038263 0.327615870206314 no 1130 0.260654841439463 334 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_54 0159-0055 9 µM 0.638036715803903 0.328360423071951 no 1131 0.26172488999952 316 3319099
SGTC_1484 3473-2379 286 µM 0.635659125897735 0.328898725657204 no 1132 0.262499311499334 292 671917
SGTC_440 fluspirilene 35.1 µM 0.635596448984143 0.328912920946898 no 1133 0.2625197422939 295 3396 An atypical antipsychotic.
SGTC_882 0843-0131 351 µM 0.632727246315563 0.329563012084928 no 1134 0.263455887024797 287 5425421
SGTC_589 1227-0070 34.1 µM 0.632253526268917 0.329670395082625 no 1135 0.263610613045599 284 2841384
SGTC_523 1934-0222 13.7 µM 0.630040710778059 0.330172182630297 no 1136 0.264333974448443 321 1361595
SGTC_1312 1218-2183 165 µM 0.62868318477149 0.330480172382533 no 1137 0.264778244409957 293 6744073
SGTC_1612 st002233 45.4 µM 0.625337852619828 0.331239637060507 no 1138 0.265874670712578 280 1035021
SGTC_1332 1480-0653 17.5 µM 0.625205837883419 0.331269621604601 no 1139 0.265917985434782 291 5749438
SGTC_160 3453-0671 289.699 µM 0.625002561272438 0.331315793993559 no 1140 0.265984688539729 302 5322268
SGTC_1144 3486-0183 12.5 µM 0.624873558433039 0.331345097117171 no 1141 0.266027023875232 325 6744069
SGTC_410 α-linolenic acid 100 µM 0.624303270187924 0.331474651031247 no 1142 0.266214218348615 285 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_1793 st048256 72.231 µM 0.624127783110169 0.331514520960832 no 1143 0.26627183458233 300 672022
SGTC_2521 angolensin 13.4 µM 0.620244371918988 0.332397303626723 no 1144 0.267548456247289 308 821428 A flavenoid.
SGTC_2546 rhodinyl acetate 100 µM 0.618544448522224 0.33278402580535 no 1145 0.268108253765196 285 6708682
SGTC_1758 st042942 75.2445 µM 0.617574992779265 0.333004650776952 no 1146 0.268427766572267 295 669317
SGTC_2479 5617353 43.85 µM 0.617115706631721 0.333109193523316 no 1147 0.268579204716381 311 2731746
SGTC_1290 0986-0249 10.2 µM 0.617044752562176 0.333125345250644 no 1148 0.26860260387866 312 53329
SGTC_747 3448-8087 38.7 µM 0.616936080516133 0.333150083561566 no 1149 0.268638443623705 318 5168703
SGTC_208 k072-0098 12.366 µM 0.613732160243184 0.333879755883838 no 1150 0.269696166435498 302 5948901
SGTC_2108 5365811 200 µM 0.613034287406474 0.334038775414927 no 1151 0.269926834301947 278 780283
SGTC_1881 5652484 16 µM 0.612555642625278 0.334147858172689 no 1152 0.270085097801785 308 2255129
SGTC_1227 3909-8010 46.6 µM 0.611979314499208 0.334279221476605 no 1153 0.27027572179909 287 15982272
SGTC_2664 lyso-paf C-16 73.48 µM 0.611306162491221 0.33443267968822 no 1154 0.270498456015415 312 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_907 3448-6986 75.5 µM 0.611167716190491 0.334464244671076 no 1155 0.27054427684116 315 590582
SGTC_1541 2',3',6-trimethoxyflavone 64 µM 0.610772011715032 0.334554469531846 no 1156 0.270675262394064 316 688801
SGTC_1872 amphotericin b 148 nM 0.608529695333252 0.335065922054417 no 1157 0.271418108548356 303 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1
SGTC_3056 9094900 49.47 µM 0.599671065852582 0.337089481624434 no 1158 0.274362737515697 301 25236784
SGTC_1475 4092-1048 11.7 µM 0.598851419589077 0.337276951432335 no 1159 0.27463598482816 318 2881759
SGTC_818 4072-2707 53.5 µM 0.598823968425518 0.33728323077258 no 1160 0.274645138606527 308 882871
SGTC_293 4049-0273 38.5 µM 0.595843606625435 0.33796524548717 no 1161 0.275639854720082 294 1380311
SGTC_2868 9035608 32.47 µM 0.595306195087997 0.338088281412349 no 1162 0.275819407803348 306 6462614
SGTC_635 k038-0028 24.7 µM 0.592824154358164 0.338656748331824 no 1163 0.276649420469005 327 4035102
SGTC_397 arbidol 50 µM 0.591981014115883 0.338849938233078 no 1164 0.276931651033586 297 131410 A RNA synthesis inhibitor.
SGTC_840 0245-0196 390 µM 0.591899663630514 0.338868580426829 no 1165 0.276958889538234 298 3827528
SGTC_473 2-arachidonoylglycerol 10 µM 0.591316840898196 0.339002151025817 no 1166 0.277154073864392 296 5282280 An endocannabinoid.
SGTC_1174 0739-0097 51.1 µM 0.589455274188406 0.339428918110554 no 1167 0.277777953372354 310 728447
SGTC_234 nsc-17383 10.7 µM 0.58433253972604 0.340604375128188 no 1168 0.279498301881922 313 408974
SGTC_820 1582-0060 59.9 µM 0.582780809105732 0.340960739883978 no 1169 0.280020432780912 307 3848840
SGTC_3062 9077494 49.47 µM 0.58121391532945 0.34132073099379 no 1170 0.280548145153527 262 16459633
SGTC_2255 7941087 197.44 µM 0.58050496286243 0.341483659067931 no 1171 0.280787070487012 312 935561
SGTC_2179 6298986 200 µM 0.580297397758807 0.341531366282468 no 1172 0.280857040988325 302 738374
SGTC_3338 9144300 39.5675 µM 0.577935029354823 0.342074516399193 no 1173 0.281653992209317 300 4901274
SGTC_3206 9114350 49.47 µM 0.575651095546892 0.342599943903565 no 1174 0.282425518534193 291 17087243
SGTC_578 3460-0051 92 µM 0.57526374346841 0.342689085944087 no 1175 0.282556469099086 337 2876744
SGTC_1256 0570-0116 285 µM 0.572224058262513 0.343388918018433 no 1176 0.28358509530985 317 410638
SGTC_1258 0671-0043 57.1 µM 0.571879476828149 0.34346828555922 no 1177 0.283701814422036 329 4298767
SGTC_540 1187-0821 17.3 µM 0.571713348806909 0.343506552340363 no 1178 0.283758094724167 320 847520
SGTC_1871 st057448 67.3 µM 0.571201708864177 0.343624416186767 no 1179 0.283931459992552 341 691747
SGTC_2904 7225135 42.03 µM 0.570849971492336 0.343705452925014 no 1180 0.284050672896414 343 4446116
SGTC_3233 9132340 49.47 µM 0.569976182651652 0.343906796126458 no 1181 0.284346926143051 346 17682950
SGTC_2087 5276107 200 µM 0.569610869905429 0.343990986613989 no 1182 0.284470827155167 308 144405
SGTC_1678 st019265 80.2 µM 0.568552075678631 0.344235041500185 no 1183 0.284830077897617 325 5367020
SGTC_652 0437-0092 114 µM 0.564921512714715 0.345072388078095 no 1184 0.286063575261363 298 3091274
SGTC_2894 9048625 32.47 µM 0.562894416764645 0.345540244435682 no 1185 0.286753391150748 345 4092861
SGTC_2039 Aminomethylbenzodioxan 200 µM 0.562835884540191 0.34555375725824 no 1186 0.286773321234285 316 15053
SGTC_535 2293-4129 48.2 µM 0.560284467222199 0.346142971709277 no 1187 0.287642710229223 340 396118 YIL048W NEO1
SGTC_2934 9036370 36.88 µM 0.559616112247156 0.346297380675686 no 1188 0.287870656220992 323 6462800
SGTC_934 2950-0684 338 µM 0.55785008792792 0.346705505307773 no 1189 0.288473378298435 338 1121253
SGTC_105 0111-0055 734.78 µM 0.556886899657367 0.346928171191819 no 1190 0.288802352889872 309 5179370
SGTC_330 1488-0319 80.1 µM 0.556352787270601 0.3470516678793 no 1191 0.288984853754819 324 6846614
SGTC_1205 4161-2785 76 µM 0.555258846429618 0.347304657987261 no 1192 0.289358811677525 300 3498106
SGTC_2450 5739737 12.93 µM 0.551638709751112 0.34814235317553 no 1193 0.290597954780357 320 2262825
SGTC_254 nsc-64875 3.808 µM 0.549322767887534 0.348678648489437 no 1194 0.291391982621802 319 56993
SGTC_1891 st059073 26.2 µM 0.546943394145257 0.34922994761632 no 1195 0.292208810962163 331 688754
SGTC_451 chloral hydrate 100 µM 0.541495894330415 0.350493326243194 no 1196 0.294082913390272 340 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1
SGTC_2249 haloperidol 116.36 µM 0.540177562557081 0.350799321762846 no 1197 0.29453729238519 320 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_1778 st046819 58.9 µM 0.52932946940327 0.353320911894675 no 1198 0.298288458000816 341 671715
SGTC_1087 pterostilbene 9.05 µM 0.528413923030497 0.353534023300773 no 1199 0.298606038022027 341 5281727 Similar to reservatol, lowers cholesterol.
SGTC_2601 securinine 100 µM 0.519033888964457 0.355720045154245 no 1200 0.301868554542003 341 442872 A GABA receptor antagonist.
SGTC_3002 9075603 71.4286 µM 0.517920660012699 0.355979800680751 no 1201 0.302256813340598 332 20105405
SGTC_1767 st044992 70.3 µM 0.517502491788694 0.356077391339626 no 1202 0.302402714970216 329 9600693
SGTC_3016 9080866 49.47 µM 0.517220704484887 0.356143159207803 no 1203 0.302501050214148 338 17066299
SGTC_1969 st069479 40.1 µM 0.516523630308705 0.356305871519277 no 1204 0.302744369584183 334 3895485
SGTC_559 1550-0661 158 µM 0.515127498316854 0.35663183782203 no 1205 0.303231964138731 335 5830875
SGTC_2342 7990637 118.86 µM 0.514349297129447 0.356813576266276 no 1206 0.303503900677464 354 2033102 YER133W GLC7
SGTC_1109 tnp00067 928.257 nM 0.513440693928278 0.357025809480773 no 1207 0.303821542970435 328 676295
SGTC_656 4090-1979 187 µM 0.508982873720579 0.358067715403992 no 1208 0.305382114337443 345 22330961
SGTC_1385 3091-4834 14.1 µM 0.508251103506747 0.358238850005335 no 1209 0.305638628115516 333 4072814
SGTC_341 1486-1430 230 µM 0.507911684074586 0.358318237612918 no 1210 0.305757640161827 339 2054753 YPL210C SRP72
SGTC_2818 7996756 12.99 µM 0.505564736062574 0.358867338216931 no 1211 0.306581121208873 347 2241621
SGTC_1905 st060207 84.5 µM 0.501462188884604 0.359827885520042 no 1212 0.308022941034616 324 1948547
SGTC_386 1509-0011 3.07 µM 0.500784003903667 0.359986757432065 no 1213 0.308261572256963 336 3107280
SGTC_2758 dehydroepiandrosterone 69.35 µM 0.500191549862558 0.36012556577385 no 1214 0.308470103890781 374 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem]
SGTC_1569 carminic acid 40.6 µM 0.499999151475513 0.360170647502088 no 1215 0.308537837462101 322 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_1653 st012112 65 µM 0.498862041444837 0.360437128538768 no 1216 0.30893828838839 341 720429
SGTC_2674 ligustilide 100 µM 0.498398932636499 0.360545677241317 no 1217 0.309101444472274 337 5319022 A signalling regulator.
SGTC_2663 amphotericin b 100 µM 0.491094068359306 0.362259355902261 no 1218 0.311679958315887 341 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM 0.488821445317292 0.362793065432983 no 1219 0.312484056973398 321 6312947
SGTC_2731 amoxapine 43.43 µM 0.488632129679494 0.362837536924131 no 1220 0.312551080935087 361 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine.
SGTC_1211 1056-0033 32.3 µM 0.483522853917788 0.364038436376872 no 1221 0.314362268306741 320 6741922
SGTC_1214 0358-0031 63.7 µM 0.477823485781382 0.365379609558784 no 1222 0.316387921865154 372 4301366
SGTC_199 4063-0024 41.6 µM 0.477120427836598 0.365545167396466 no 1223 0.316638184530967 351 306215
SGTC_1594 piperine 70.1 µM 0.476880467040513 0.365601679698972 no 1224 0.31672362093715 345 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_1417 3966-0327 90.4 µM 0.475529187014887 0.365919969226162 no 1225 0.317204917424805 353 651118
SGTC_3235 9132602 49.47 µM 0.475044374427471 0.366034187733912 no 1226 0.31737767254401 342 4912240
SGTC_2708 st078559 56 µM 0.473631745081241 0.366367061147618 no 1227 0.317881266920894 335 17250902
SGTC_256 clotrimazole 625 nM 0.472586993615652 0.366613312153213 no 1228 0.318253931773762 336 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C
SGTC_2059 5238311 157 µM 0.471955619921211 0.366762155426085 no 1229 0.318479233221507 333 703021
SGTC_502 l-744,832 89.3 µM 0.471388464088004 0.366895876734603 no 1230 0.318681676208835 375 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.
SGTC_2153 5569715 200 µM 0.47112163072984 0.366958795024758 no 1231 0.31877693955691 371 2054701
SGTC_1002 4049-0206 172 µM 0.470162313750966 0.367185027826538 no 1232 0.319119528411949 352 4662749
SGTC_1695 st026914 34.495 µM 0.469709843201586 0.367291748589508 no 1233 0.319281167205762 332 3289191
SGTC_287 k060-0039 29.6 µM 0.469707843549416 0.367292220254911 no 1234 0.319281881629886 338 5861974
SGTC_2659 sanguinarine 24.21 µM 0.468042737347188 0.367685044498301 no 1235 0.319877013816456 358 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis.
SGTC_1111 tnp00062 510.699 nM 0.465241198530698 0.368346283009548 no 1236 0.320879369277603 332 676306
SGTC_3346 9158254 43.5805 µM 0.461657842073953 0.369192619959143 no 1237 0.322163353910037 348 17639500
SGTC_143 4032-1194 15.74 µM 0.460017428597158 0.369580273850001 no 1238 0.322751855321115 343 1806963
SGTC_2869 9037858 32.47 µM 0.458762033098827 0.369877031915609 no 1239 0.32320253096726 340 27187042
SGTC_2622 2-methoxyxanthone 59.94 µM 0.455850686489457 0.370565531847379 no 1240 0.324248676366133 342 71034 A hepatoprotective.
SGTC_136 0097-0015 404.482 µM 0.45157604647088 0.371577186023542 no 1241 0.325787214720786 338 4861337
SGTC_96 0929-0093 37.281 µM 0.451032730058448 0.371705833281522 no 1242 0.325982979825161 337 6991579
SGTC_1295 1013-0063 9.78 µM 0.450783644070762 0.371764817018576 no 1243 0.326072745309243 361 6826038
SGTC_2817 7995342 71.43 µM 0.449470905319664 0.372075724186574 no 1244 0.326545995887204 346 18879975
SGTC_1856 st057054 55.7 µM 0.444379204335835 0.373282422975917 no 1245 0.328384222953636 379 1266018
SGTC_361 000s-0510 1.45 µM 0.44435334305037 0.373288555110896 no 1246 0.328393570163186 340 660
SGTC_3289 9119912 71.43 µM 0.443413537231852 0.373511420248409 no 1247 0.328733323019774 366 17014829
SGTC_56 0957-0365 83.25 µM 0.43966286023694 0.374401274848247 no 1248 0.330090652782692 347 6752360
SGTC_2052 5265182 7.135 µM 0.438381925309345 0.374705332469827 no 1249 0.330554723330522 373 1239884
SGTC_2049 5262831 67.185 µM 0.434288885360228 0.375677425458612 no 1250 0.332039336975234 368 763417
SGTC_2070 5230947 200 µM 0.434170493783135 0.375705555123113 no 1251 0.332082318971441 395 2835538
SGTC_3231 9132313 49.47 µM 0.433249697684904 0.375924357461167 no 1252 0.332416688861201 365 4905967
SGTC_1994 st072947 40.9 µM 0.432586146878417 0.376082057138448 no 1253 0.332657727660257 382 5286565 YDL195W SEC31
SGTC_3083 9117465 49.47 µM 0.431592096696839 0.376318342108364 no 1254 0.333018951788158 378 16420915
SGTC_2427 5545055 42.75 µM 0.430915523823828 0.376479189484743 no 1255 0.333264897711827 363 5372858
SGTC_1073 triclabendazole 3.09 µM 0.430351406065847 0.376613318357984 no 1256 0.333470019088627 354 50248 An antihelmetic and likely tubulin inhibitor.
SGTC_1334 1486-0610 236 µM 0.43008017840588 0.376677812786825 no 1257 0.333568659121513 353 3742339
SGTC_2231 micatex 6.853 µM 0.428501438602079 0.37705328496444 no 1258 0.33414304319963 368 20737 An antifungal of unknown mechanism.
SGTC_3035 9091303 49.47 µM 0.426744209743415 0.377471343990644 no 1259 0.334782823001035 356 25237002
SGTC_3184 9108758 49.47 µM 0.425863222429573 0.377680992110998 no 1260 0.335103757560345 367 902885
SGTC_406 estrone 100 µM 0.424625095083446 0.377975689574719 no 1261 0.33555499804805 384 5870 A steroid.
SGTC_683 panaxydol 45 µM 0.422399432729135 0.378505617322024 no 1262 0.336366745941745 352 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis.
SGTC_2566 crystal violet carbinol 226 nM 0.422278745233715 0.378534359423082 no 1263 0.336410785172092 386 68050 Cationic dye that binds acidic phospholipids including cardiolipin.
SGTC_2442 5158906 48.48 µM 0.421249990691686 0.378779387766632 no 1264 0.336786271855361 357 1893835
SGTC_1610 st001799 48.1 µM 0.416787763285077 0.379842762228346 no 1265 0.338416826831563 365 621897
SGTC_419 nsc-638432 893 µM 0.415722668068757 0.380096715257327 no 1266 0.338806475976002 352 368090
SGTC_1637 st007924 17.4 µM 0.412465914762236 0.380873550542737 no 1267 0.339998979430258 362 683336
SGTC_2262 9014885 67.46 µM 0.412368248587588 0.380896854348377 no 1268 0.340034766005306 376 6457424
SGTC_1545 lovastatin 49.4 µM 0.412074666825244 0.380966907530881 no 1269 0.340142348115974 350 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12
SGTC_1197 1601-0112 267 µM 0.41171769420212 0.381052092016592 no 1270 0.340273177141689 358 7350313
SGTC_1086 cerivastatin 2.18 µM 0.408626752352773 0.381789925058553 no 1271 0.341406797489991 355 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7
SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM 0.407899887961042 0.381963496017484 no 1272 0.341673587510239 398 442882
SGTC_2055 5235184 200 µM 0.405891769703229 0.382443146131069 no 1273 0.342411062806636 405 2836034
SGTC_3212 9128307 49.47 µM 0.405679940253041 0.382493753294824 no 1274 0.342488891631012 353 27243542
SGTC_3172 9105863 49.47 µM 0.404236247928366 0.38283871234852 no 1275 0.343019500464886 370 2348785
SGTC_866 0495-0101 262 µM 0.401973669573817 0.383379524759561 no 1276 0.343851702124743 378 635694
SGTC_1414 3917-0015 5.4 µM 0.401513542266384 0.383489534460949 no 1277 0.344021034872949 388 6618702
SGTC_3170 9103054 49.47 µM 0.400247093567656 0.383792372283086 no 1278 0.344487265704588 383 16432970
SGTC_1609 st001574 46.4 µM 0.399108756397245 0.384064636195391 no 1279 0.344906535264308 416 3960012
SGTC_2874 9043904 71.43 µM 0.398596111547196 0.384187267678415 no 1280 0.345095413609365 373 4463428
SGTC_2862 9027634 71.43 µM 0.398405718188143 0.384232815261687 no 1281 0.345165571776158 341 5012562
SGTC_1046 2001-0062 216 µM 0.397518377159403 0.384445113909051 no 1282 0.345492618787537 369 739778
SGTC_3112 9123419 49.47 µM 0.396558369058511 0.384674837380176 no 1283 0.345846578614112 399 17015854
SGTC_3272 9137413 49.47 µM 0.396426605407887 0.384706370696606 no 1284 0.345895171061344 375 17614870
SGTC_690 glyoxal 20.3 µM 0.395288255680293 0.384978829178384 no 1285 0.34631508288847 371 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins.
SGTC_553 k007-0256 45.7 µM 0.394130110484986 0.385256083902004 no 1286 0.34674249077063 363 6287000
SGTC_944 3370-0224 231 µM 0.393908958818288 0.385309033285664 no 1287 0.346824127927246 345 4580514
SGTC_3109 9122853 49.47 µM 0.392032435102018 0.385758407162431 no 1288 0.34751712419633 418 1234709
SGTC_3102 9121669 49.47 µM 0.391097238146725 0.385982417444126 no 1289 0.347862681013837 386 41905072
SGTC_184 1494-0393 24.714 µM 0.390513451723815 0.38612227268132 no 1290 0.348078455161438 365 3090647
SGTC_2720 fluspirilene 36.88 µM 0.390478291629207 0.386130696308732 no 1291 0.348091452306431 378 3396 An atypical antipsychotic.
SGTC_491 tetrandrine 80.3 µM 0.389636427281306 0.386332405518785 no 1292 0.348402705890933 392 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_108 0509-0257 621.132 µM 0.389362741994143 0.386397986649879 no 1293 0.34850391465557 371 536624
SGTC_1412 3909-8563 178 µM 0.388903163482962 0.386508119264638 no 1294 0.34867389095654 401 23767530
SGTC_612 0302-0167 22.4 µM 0.388844030539666 0.386522290446882 no 1295 0.348695763635342 395 235821
SGTC_1469 k284-2957 126 µM 0.388253251203899 0.386663878744793 no 1296 0.34891431454961 369 23884841
SGTC_2466 5983409 37.09 µM 0.387780984718286 0.386777074679742 no 1297 0.34908905928103 386 2879657
SGTC_571 k831-0106 44.2 µM 0.385751357945768 0.387263658504803 no 1298 0.349840411456901 403 4783639
SGTC_2709 st078560 56 µM 0.383683673278014 0.387759548552311 no 1299 0.350606457498049 395 17250903
SGTC_1474 0330-0125 5.35 µM 0.382447383216778 0.388056133877086 no 1300 0.35106477496389 365 X1474
SGTC_1068 loratadine 26.9 µM 0.381416233940805 0.388303555995316 no 1301 0.351447208446644 385 3957 A H1 histamine antagonist.
SGTC_1787 fluconazole 80 µM 0.381031302553778 0.388395931105164 no 1302 0.351590010693444 360 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C
SGTC_3138 9097216 49.47 µM 0.379107368735825 0.388857727653934 no 1303 0.352304067283782 412 25237486
SGTC_2853 9015042 58.44 µM 0.375139241392322 0.389810681795828 no 1304 0.353778457058205 353 6457456
SGTC_2242 6630449 61.2675 µM 0.37489262180983 0.389869929941895 no 1305 0.353870163258105 387 691249 YDR170C SEC7
SGTC_1645 Cervolide 78 µM 0.374110900376586 0.39005774842034 no 1306 0.354160904629524 401 23173 A fragrance.
SGTC_1735 st034310 56.75 µM 0.371988049757684 0.390567919561491 no 1307 0.354950873425368 426 871153
SGTC_1600 coumarin 106 71.1 µM 0.3685008135526 0.391406393487211 no 1308 0.356249919315232 415 100336 A hepatotoxic, DNA x-linker.
SGTC_1537 2',6'-dihydroxyflavanone 78 µM 0.368053295475436 0.391514031731321 no 1309 0.356416747491468 381 5106787 A p450 inhibitor.
SGTC_1505 k297-0037 20.6 µM 0.367507041507373 0.391645429453486 no 1310 0.356620420201004 361 4089396
SGTC_927 2425-1185 123 µM 0.366135346478861 0.391975435945176 no 1311 0.35713204165602 406 730375
SGTC_367 0335-0881 7.1 µM 0.365688047267358 0.392083065344224 no 1312 0.357298933092867 405 23828853
SGTC_2661 dactinomycin 12.96 µM 0.364477081439017 0.392374490070675 no 1313 0.357750892468952 378 45006140 An Actinomycin D Classic transcription inhibitor.
SGTC_1658 st012944 20 µM 0.361471657344752 0.393098020275789 no 1314 0.358873444431286 395 24207260
SGTC_3312 9133330 71.43 µM 0.36019075782593 0.393406498331764 no 1315 0.359352242857304 407 17617324
SGTC_1382 3002-2117 298 µM 0.359988010382102 0.393455331984272 no 1316 0.35942804983697 412 1497314
SGTC_1650 st011916 45.8 µM 0.358505877364549 0.393812368699592 no 1317 0.35998238514954 408 242528
SGTC_896 0964-0007 44.5 µM 0.358463729274917 0.393822523221752 no 1318 0.359998153347904 386 6756758
SGTC_2379 9035213 200 µM 0.358427310138751 0.393831297554803 no 1319 0.360011778455355 414 646551
SGTC_2033 5192550 145 µM 0.357497452320065 0.394055343139254 no 1320 0.360359716556445 358 182073
SGTC_2655 perillic acid 100 µM 0.356948327849154 0.39418766899413 no 1321 0.360565244601727 387 5702197 An apoptosis inducer.
SGTC_1462 k081-0014 26.5 µM 0.356108880747694 0.394389979258163 no 1322 0.360879513373517 368 3270634
SGTC_2738 aclarubicin 5.55 µM 0.355285980331166 0.39458832935817 no 1323 0.361187678666296 385 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31
SGTC_1812 st052057 4.327 µM 0.352506880012412 0.395258399296624 no 1324 0.362229079843992 369 3645418
SGTC_776 4476-4378 112 µM 0.351069896305097 0.395604992631896 no 1325 0.362767955798526 387 2892008
SGTC_2922 7999257 32.47 µM 0.350409289123445 0.39576435552766 no 1326 0.36301577803586 391 2988377
SGTC_3256 9138902 49.47 µM 0.348890830246251 0.396130730019023 no 1327 0.363585634780055 406 17228773
SGTC_2905 7799065 20.05 µM 0.347994282789874 0.396347092528726 no 1328 0.363922238575183 410 1296806
SGTC_3268 9137683 49.47 µM 0.346786424837715 0.396638633623162 no 1329 0.364375888208214 440 1953228
SGTC_1429 4049-0205 9.46 µM 0.345094137243594 0.397047198845232 no 1330 0.365011800419557 376 22774478
SGTC_1513 0337-0559 19 µM 0.344062018768475 0.397296436421717 no 1331 0.365399822847792 384 775073
SGTC_3241 9133421 49.47 µM 0.343363403488513 0.397465162937151 no 1332 0.365662543797027 408 17018221
SGTC_565 1418-0001 44.5 µM 0.33803372399741 0.398752993221083 no 1333 0.367668887010411 395 2862145
SGTC_1444 4112-3581 28 µM 0.335262292569711 0.39942310137683 no 1334 0.368713617753308 385 2877249
SGTC_2274 7947094 46.08 µM 0.334520327174228 0.399602552577683 no 1335 0.3689934773276 381 2971028
SGTC_2448 5185112 27.17 µM 0.332872879575213 0.400001078815192 no 1336 0.369615121037066 371 5718189
SGTC_1548 st061468 90.8 µM 0.33268157735745 0.400047362586034 no 1337 0.369687328657972 421 390799
SGTC_1986 st071812 45 µM 0.331926979765593 0.400229944056776 no 1338 0.369972198674865 414 11838594
SGTC_2737 bleomycin 30.5 nM 0.330819044381198 0.400498058194868 no 1339 0.370390587386678 418 16211318 Bleomycin acts by induction of DNA strand breaks.
SGTC_148 3253-0744 288.01 µM 0.32977272836368 0.400751303847357 no 1340 0.370785847656507 384 6893655
SGTC_1466 k213-0079 57.5 µM 0.328030847917659 0.401172993294602 no 1341 0.371444169335482 417 3657981
SGTC_2923 7992654 58.14 µM 0.32554381377053 0.401775275446573 no 1342 0.37238476412574 392 2985126
SGTC_2607 solasodine 47.35 µM 0.32404626837773 0.402138046924651 no 1343 0.37295150269246 387 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity.
SGTC_496 calpeptin 138 µM 0.323737071402119 0.402212958567498 no 1344 0.373068551041798 390 73364 A calpain inhibitor.
SGTC_1289 0976-0073 69.1 µM 0.32271498934533 0.402460612169643 no 1345 0.373455549594178 403 3391136
SGTC_25 0118-0223 35.662 µM 0.32056292256163 0.402982192415162 no 1346 0.374270819669336 420 5333628
SGTC_1659 st012954 42.1 µM 0.320052798393121 0.40310585272637 no 1347 0.374464153243022 404 24207262
SGTC_721 1187-1332 279 µM 0.31739149372559 0.403751142280703 no 1348 0.375473280421528 413 25730
SGTC_2335 9018011 154.17 µM 0.316882448459556 0.403874600973288 no 1349 0.375666400173256 434 6458208
SGTC_2107 5363541 170.161 µM 0.316846782141358 0.403883251480676 no 1350 0.375679932300447 422 244052
SGTC_2666 tannic acid 100 µM 0.316754285491829 0.403905685833384 no 1351 0.375715027087412 392 16134267 A thiamine antagonist.
SGTC_750 4073-0104 132 µM 0.313321753409356 0.404738443074874 no 1352 0.377018112377929 420 22330957
SGTC_1662 st014054 52 µM 0.313082403702973 0.404796527196278 no 1353 0.377109028685176 421 2838777
SGTC_1806 st050005 60.3 µM 0.312322699061027 0.404980902192793 no 1354 0.377397645448897 409 5194765
SGTC_912 3474-0017 2.18 µM 0.309745602663953 0.405606502357185 no 1355 0.378377210562942 426 3360550
SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM 0.309688692068956 0.405620320353023 no 1356 0.378398851367633 385 5711223 A potent inhibitor of glutathione S-transferases.
SGTC_1012 4112-3522 18 µM 0.308697710756272 0.405860951255799 no 1357 0.378775742694788 393 3112398
SGTC_1101 ebselen 5.29 µM 0.301238958397275 0.407673227075909 no 1358 0.381616142100009 430 3194 A potent scavenger of hydrogen peroxide and hydroperoxides.
SGTC_449 xestospongin c 11.1929 µM 0.298338888481351 0.408378401997628 no 1359 0.382722263093171 430 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1
SGTC_899 1083-0020 478 µM 0.298313384729967 0.408384604756183 no 1360 0.382731994785201 441 767123
SGTC_1180 1193-0155 285 µM 0.297102124206572 0.408679221414834 no 1361 0.383194271336907 414 2921347
SGTC_2660 2',4'-dihydroxychalcone 17.14 µM 0.29522751144675 0.409135287899274 no 1362 0.383910043510153 401 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_408 cantharidin 100 µM 0.292900886492883 0.409701493530199 no 1363 0.384798955616817 398 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_1624 st003710 6.25 µM 0.291234807947318 0.410107064917248 no 1364 0.385435871448914 440 24207033
SGTC_773 4358-1457 44.6 µM 0.289395636293158 0.410554883810983 no 1365 0.386139316970832 440 1186886
SGTC_715 0868-0130 184 µM 0.288286955980866 0.410824892154589 no 1366 0.386563545566989 406 2876258
SGTC_785 1270-0111 65.3 µM 0.288135244852531 0.410861843219324 no 1367 0.38662160730471 392 6741994
SGTC_3353 9151644 39.2805 µM 0.286241743316727 0.41132309467247 no 1368 0.387346487050045 456 4909158
SGTC_2743 auranofin 4.32 µM 0.281861896690006 0.412390481305614 no 1369 0.389024703715259 427 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold.
SGTC_1427 4048-4900 550 nM 0.280666044601803 0.41268202837901 no 1370 0.389483277385816 432 24132586
SGTC_2938 9059746 27.26 µM 0.280635590283243 0.412689453729216 no 1371 0.389494957722876 424 6471769
SGTC_846 0335-0850 148 µM 0.278850095990944 0.413124846199755 no 1372 0.390179933780684 424 6819598
SGTC_215 1287-0124 461.5 µM 0.277832516950001 0.413373030516265 no 1373 0.390570464284645 437 5560863
SGTC_3290 9121031 71.43 µM 0.274887357538469 0.414091540352036 no 1374 0.391701390176696 415 17014854
SGTC_2341 7987486 176.74 µM 0.274458363201668 0.414196223141907 no 1375 0.391866198411963 455 1258686
SGTC_1347 1493-0251 600 nM 0.273969464093187 0.414315531269236 no 1376 0.392054044128357 421 3986378
SGTC_2079 5212404 121 µM 0.27381175496094 0.414354019386267 no 1377 0.392114644791388 408 758462
SGTC_827 3253-0474 693 µM 0.273054862380703 0.414538746635569 no 1378 0.392405521617326 396 5402065
SGTC_3134 9127454 49.47 µM 0.272122204503823 0.414766397167323 no 1379 0.392764028414936 439 24262820
SGTC_1692 fluoroquinolonic acid 71 µM 0.271368797209186 0.414950315702422 no 1380 0.393053699072419 431 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2
SGTC_193 1273-0060 1.558 µM 0.271312937500904 0.414963952675988 no 1381 0.393075178419482 427 2847393 YHR072W ERG7
SGTC_3 0833-0587 95.581 µM 0.270873377674147 0.415071265542027 no 1382 0.393244210672291 408 5382644
SGTC_3080 9117754 49.47 µM 0.270198228073258 0.415236106953753 no 1383 0.393503877904755 427 9550191
SGTC_1135 dihydrocapsaicin 536.708 nM 0.268825570496093 0.415571294674366 no 1384 0.394031957509644 432 107982 A Capsaicinoid.
SGTC_966 1300-0360 30.2 µM 0.267212228289749 0.415965333437427 no 1385 0.394652880777297 434 70588
SGTC_1589 2',5'-dimethoxyflavone 47.2 µM 0.264249387623748 0.416689190205715 no 1386 0.395793878629275 467 688667
SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM 0.262282858731516 0.417169792484071 no 1387 0.39655168815974 435 6708760
SGTC_897 1000-0139 31.4 µM 0.259494703337137 0.417851405035474 no 1388 0.397626784111565 454 6151020
SGTC_2719 novobiocin 32.65 µM 0.256266077402634 0.418641006499981 no 1389 0.398872694567953 433 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication.
SGTC_1331 1472-0049 76.2 µM 0.255908650574321 0.418728439986787 no 1390 0.399010687402186 430 24051409
SGTC_2969 9091408 28.7 µM 0.253447352353744 0.41933062973061 no 1391 0.399961269955055 406 4286311
SGTC_828 2074-0507 139 µM 0.252951594822399 0.41945194639823 no 1392 0.400152809335522 423 X828
SGTC_2104 5389443 200 µM 0.252878509130086 0.419469831822607 no 1393 0.400181048535274 427 2244536
SGTC_3143 9086658 49.47 µM 0.252773594165105 0.419495506751153 no 1394 0.400221586994129 417 25236626
SGTC_231 b-estradiol 524 µM 0.25218399279135 0.419639801148971 no 1395 0.400449425108826 419 450 A steroid.
SGTC_99 0109-0120 622.8 µM 0.251189492852043 0.419883211708531 no 1396 0.400833803844448 451 759414
SGTC_1506 4226-2149 212 µM 0.248943040205834 0.420433158809464 no 1397 0.401702420895331 436 991114
SGTC_3146 9095609 49.47 µM 0.248019235239458 0.420659357776722 no 1398 0.402059762060274 409 17173999
SGTC_164 4100-3994 89.624 µM 0.247908877880913 0.420686381164939 no 1399 0.40210245536858 471 4615967
SGTC_2878 9043973 25.97 µM 0.246616972873837 0.421002759838794 no 1400 0.40260233387517 420 6465167
SGTC_299 1273-0059 1.44 µM 0.237506566484523 0.423235273068042 no 1401 0.406131912804573 427 2848077
SGTC_703 3875-0075 71.8 µM 0.236073466638931 0.423586681858102 no 1402 0.406687831321581 459 2850814
SGTC_3104 9120930 49.47 µM 0.23566387485153 0.423687128577414 no 1403 0.406846752042692 449 17014836
SGTC_2520 obtusaquinone 4.71 µM 0.234428984815851 0.423989998261898 no 1404 0.407325979431211 462 5967872
SGTC_835 0312-0010 67.2 µM 0.232292103783981 0.424514196637246 no 1405 0.408155572496866 421 1626196
SGTC_279 1273-0055 2.93 µM 0.230409080674047 0.424976231836017 no 1406 0.40888695280382 449 2847562
SGTC_1248 0469-0687 58.6 µM 0.230019343074296 0.425071874195329 no 1407 0.40903836953742 435 4017482
SGTC_1226 3909-7979 35.4 µM 0.228391483683076 0.425471401651007 no 1408 0.409670954775462 460 6615510
SGTC_2040 5100729 123 µM 0.228094519555158 0.425544294175134 no 1409 0.409786380284616 452 11840 YJR013W | YDR381W GPI14 | YRA1
SGTC_2337 9009472 200 µM 0.227032252880242 0.425805057928852 no 1410 0.410199331371166 458 5742383
SGTC_472 calcifediol 10 µM 0.225936516108863 0.426074071875152 no 1411 0.410625398152504 436 5283731 A vitamin D metabolite.
SGTC_1700 st030840 7.9285 µM 0.225840307613593 0.426097693633582 no 1412 0.410662812952251 438 5499307
SGTC_2101 5377231 179.231 µM 0.224964093440288 0.426312839839382 no 1413 0.411003603790512 455 2844213
SGTC_2772 vinpocetine 57.06 µM 0.224145047145758 0.426513968839638 no 1414 0.411322220763803 468 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor.
SGTC_2669 eugenol 100 µM 0.217503887746641 0.428145505593427 no 1415 0.413907838767895 454 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism.
SGTC_2895 9054447 58.44 µM 0.216446747828904 0.428405327771374 no 1416 0.414319765141185 431 2697450
SGTC_2252 omeprazole 400 µM 0.21593678288574 0.428530677253402 no 1417 0.414518512407932 464 4594 A proton pump inhibitor.
SGTC_1176 0848-0131 83.3 µM 0.215408948806099 0.428660426566264 no 1418 0.414724246815729 471 6769040
SGTC_2235 salicylic acid 500 µM 0.214893705395023 0.428787088346424 no 1419 0.414925096309695 429 338 A COX inhibitor and kinase inhibitor.
SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM 0.21335975743416 0.42916422063502 no 1420 0.4155231833539 461 364106
SGTC_836 0330-0104 1.35 µM 0.209167744054792 0.430195186554774 no 1421 0.417158645985997 407 46494820
SGTC_335 4077-0256 27.6 µM 0.20755515876326 0.430591906092608 no 1422 0.417788159963376 467 3121989
SGTC_736 0958-0254 92.6 µM 0.206725678817202 0.430795997588768 no 1423 0.418112050884596 472 6812352
SGTC_2668 2',4'-dihydroxychalcone 15.08 µM 0.204811781329956 0.431266977786786 no 1424 0.4188595909826 477 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_2246 7293507 91.5585 µM 0.201151021158491 0.432168105271842 no 1425 0.420290244048931 479 887656
SGTC_2507 purpurin 79.67 µM 0.200914630611309 0.432226307014078 no 1426 0.420382663703167 473 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1
SGTC_1223 0764-0573 147 µM 0.199751131624592 0.43251279363724 no 1427 0.420837611141839 440 1609797
SGTC_222 nsc-310342 10.666 µM 0.197843101011923 0.432982681913359 no 1428 0.421583911445202 480 432556
SGTC_2966 9084041 48.03 µM 0.197804887188933 0.432992093753263 no 1429 0.421598861150826 421 17741380
SGTC_1530 rhein 70.4 µM 0.19576606255265 0.433494299253107 no 1430 0.422396637106598 461 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death.
SGTC_2358 9037157 4 µM 0.189522860567792 0.435032796131259 no 1431 0.42484151981093 468 2388925
SGTC_1878 temozolomide 1 mM 0.189424510271812 0.435057040286764 no 1432 0.424880057892417 479 5394 DNA alkylating agent.
SGTC_2965 9082772 38.63 µM 0.189041073418145 0.435151562950234 no 1433 0.425030312597118 431 16459634
SGTC_2214 7179297 48.276 µM 0.184332447168277 0.436312607148329 no 1434 0.426876330438183 470 769744
SGTC_893 0958-0369 48.9 µM 0.182759464683713 0.436700593030636 no 1435 0.427493377672726 473 6819948
SGTC_587 k089-0003 57 µM 0.182378823677035 0.436794489660629 no 1436 0.427642721678138 493 9659696
SGTC_1093 fluphenazine 7.97 µM 0.182284978845648 0.43681763987729 no 1437 0.427679543170038 480 6602611 An atypical antipsychotic.
SGTC_1441 4106-0040 13 µM 0.180506118269735 0.437256500913062 no 1438 0.428377625801678 436 2904180
SGTC_383 2324-0395 7.37 µM 0.177822482617319 0.437918724106502 no 1439 0.429431195082877 469 3146421
SGTC_3100 9120536 49.47 µM 0.176400786057632 0.438269617441491 no 1440 0.429989543581811 464 16421196
SGTC_1428 4049-0204 61.7 µM 0.176369633289044 0.438277306897302 no 1441 0.430001779903498 467 X1428
SGTC_2835 9006588 71.43 µM 0.175207443591929 0.438564187475049 no 1442 0.430458317831876 393 2345538
SGTC_1524 corynanthine 62.1 µM 0.173673208404392 0.438942954992161 no 1443 0.431061147055108 470 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist.
SGTC_1751 st044839 27.194 µM 0.171985317618049 0.439359721142813 no 1444 0.431724535924061 468 5291326
SGTC_858 0438-0351 2.77 µM 0.170529497478131 0.439719239501071 no 1445 0.432296869228707 477 2799119
SGTC_1259 0671-0132 43 µM 0.169307827496378 0.44002097228173 no 1446 0.43277725970703 434 X1259
SGTC_1702 st027038 51 µM 0.1682388532526 0.440285020263311 no 1447 0.433197688033825 450 5521182
SGTC_39 0986-0283 58.349 µM 0.167445069492687 0.440481110464674 no 1448 0.433509932698065 449 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2
SGTC_1154 4088-0362 150 µM 0.167420351920557 0.440487216737133 no 1449 0.433519656328239 475 6618304
SGTC_2992 9074591 71.4286 µM 0.162531478307434 0.441695249048223 no 1450 0.435443670857348 469 17741321
SGTC_2060 5238662 140 µM 0.162288374791729 0.441755333763829 no 1451 0.43553938444934 448 790130
SGTC_1340 1486-1359 257 µM 0.161080245497846 0.442053951129859 no 1452 0.436015099434215 470 4309068
SGTC_2395 5646831 180.19 µM 0.156599107456871 0.443161855335916 no 1453 0.437780403006056 472 6808628
SGTC_1720 st037298 9.481 µM 0.156391797444555 0.443213120915791 no 1454 0.437862101156945 475 597396
SGTC_2005 4024620 188 µM 0.150736499079853 0.44461198036657 no 1455 0.440091790039529 501 236743
SGTC_275 trichlorophene 5.69 µM 0.148527141164064 0.445158661847301 no 1456 0.440963383973695 487 62616
SGTC_1801 st050089 28.441 µM 0.148364154285847 0.445198995313906 no 1457 0.441027693842903 440 5008493 YIL048W | YNL267W NEO1 | PIK1
SGTC_628 1636-0253 16 µM 0.148201305755075 0.445239295110993 no 1458 0.441091950677388 476 4456143
SGTC_971 1315-0384 26.7 µM 0.14557918305489 0.445888264151677 no 1459 0.442126801201564 484 6769120
SGTC_2687 chenodiol 100 µM 0.144837590313361 0.446071832944187 no 1460 0.442419551181284 471 5702181 A cholesterol synthesis inhibitor.
SGTC_2017 5132927 60.65 µM 0.144097288156958 0.446255093803531 no 1461 0.442711823055818 460 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis
SGTC_325 2810-4341 181 µM 0.141889708209454 0.446801645429137 no 1462 0.443583561862798 465 774970
SGTC_1399 3562-5772 25 µM 0.141210933366978 0.446969716554024 no 1463 0.443851654524195 486 23847490
SGTC_1967 st070177 51.4 µM 0.139682570451346 0.447348188611846 no 1464 0.444455399074238 497 5729214
SGTC_608 k048-0125 159 µM 0.137926959994736 0.447782993659221 no 1465 0.445149071523083 497 6817652 YLR060W | YFL022C FRS1 | FRS2
SGTC_3167 9103034 49.47 µM 0.135599049005716 0.448359634783973 no 1466 0.446069128646405 452 5127859
SGTC_2776 terbinafine 19.92 µM 0.134254446565169 0.448692752756211 no 1467 0.446600686714106 480 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_3147 9097027 49.47 µM 0.132816713453696 0.449048983362659 no 1468 0.447169168020698 481 25236841
SGTC_1415 3966-0071 78.1 µM 0.131828813724936 0.449293781491438 no 1469 0.447559847693648 489 2893185
SGTC_2993 9054257 71.4286 µM 0.131716609870251 0.449321586440073 no 1470 0.447604223605238 488 6470217 YGL055W OLE1
SGTC_1122 capsaicin 818.572 nM 0.129570495418516 0.449853457285805 no 1471 0.448453123834316 498 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_1000 4048-0884 8.67 µM 0.125615178244128 0.45083393759489 no 1472 0.450018273814448 483 13040088
SGTC_179 1273-0063 6.77 µM 0.124881443970552 0.451015855554518 no 1473 0.450308704461981 494 3108139
SGTC_1954 st077032 68.9 µM 0.124825532204769 0.451029718426461 no 1474 0.45033083685111 499 698907
SGTC_303 1348-1668 34.2 µM 0.123668483110584 0.451316612812454 no 1475 0.450788883444404 476 5380509
SGTC_1859 st055998 20 µM 0.123524598584919 0.451352291266799 no 1476 0.450845848298694 474 676301
SGTC_2847 9005661 71.43 µM 0.123326183767201 0.451401492018066 no 1477 0.45092440372394 501 2991449
SGTC_1182 1222-0449 220 µM 0.122484810390511 0.451610134934998 no 1478 0.451257537482309 505 658318
SGTC_1369 1866-0067 208 µM 0.122326408005468 0.451649416894796 no 1479 0.451320259242225 483 3531355
SGTC_508 roscovitine 141 µM 0.121088695255352 0.451956371616419 no 1480 0.451810391583465 504 160355 A CDKinase inhibitor.
SGTC_3238 9133470 49.47 µM 0.117850223241306 0.45275965323427 no 1481 0.453093167196801 494 3534688
SGTC_269 exalamide 29 µM 0.117433451990507 0.452863044706953 no 1482 0.4532582883012 472 3316 A derivative of salicylamide.
SGTC_2234 tolnaftate 200 µM 0.117039028770313 0.452960895084784 no 1483 0.453414562756157 495 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7
SGTC_162 k030-0015 37.8 µM 0.115414948067484 0.453363834737457 no 1484 0.454058115646483 485 1809920 YMR134W ERG29
SGTC_2846 9008642 19.48 µM 0.114736387197986 0.453532202120669 no 1485 0.454327035778989 502 2992898
SGTC_2775 cyproheptadine 69.59 µM 0.114494922207029 0.453592117448537 no 1486 0.454422735710984 503 2913 A selective serotonin reuptake inhibitor.
SGTC_310 1273-0058 1.06 µM 0.112576478065007 0.454068183340539 no 1487 0.45518316713214 480 2734232
SGTC_2090 5301565 104.445 µM 0.112372933508776 0.454118697228822 no 1488 0.455263857653719 486 2056344
SGTC_3305 9127027 53.8275 µM 0.112215268220307 0.454157825716201 no 1489 0.455326361671664 482 41905295
SGTC_2230 bromochlorosalicylanilide 954.5 nM 0.112054008712649 0.454197846656989 no 1490 0.455390291707371 481 77254
SGTC_2958 9077254 16.72 µM 0.11173953590739 0.454275892989581 no 1491 0.455514965244955 485 16457351
SGTC_2291 7917025 104.35 µM 0.110591210117421 0.454560901178303 no 1492 0.455970259019181 497 2964612
SGTC_3141 9094609 49.47 µM 0.109349459633035 0.454869123189407 no 1493 0.456462659322405 491 25236309 YDL196W YDL196W
SGTC_1531 st059297 52.4 µM 0.107257310698949 0.455388488842143 no 1494 0.457292425120323 496 7566702
SGTC_688 0527-0193 473 µM 0.106598054035097 0.455552161898931 no 1495 0.45755393122228 508 4007154
SGTC_1202 1988-0068 29.6 µM 0.104493434536897 0.456074724232498 no 1496 0.458388889119469 501 2850480
SGTC_3175 9106517 49.47 µM 0.104272648808689 0.456129548207511 no 1497 0.458476491329883 495 41468073
SGTC_3076 9116187 49.47 µM 0.103806607671106 0.456245275039452 no 1498 0.458661411319695 500 27241210
SGTC_355 1311-2252 105 µM 0.103441996916166 0.456335817376749 no 1499 0.458806091090514 512 5338538
SGTC_260 nsc-65238 3.989 µM 0.100965657047206 0.456950816751094 no 1500 0.459788861264851 471 3246252
SGTC_1861 st057647 17.4 µM 0.0983882644921342 0.457591022073865 no 1501 0.460811996522431 518 688668
SGTC_2025 5147754 141 µM 0.0956328797040384 0.458275561038863 no 1502 0.461906075321424 508 315777 YLR208W SEC13
SGTC_401 neomycin 50 µM 0.0955025489654389 0.458307943071369 no 1503 0.46195783286726 469 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis.
SGTC_3223 9129970 49.47 µM 0.0945970192044515 0.458532939021574 no 1504 0.462317458774966 496 17248386
SGTC_78 0336-0123 156.75 µM 0.0926605711805651 0.45901413055428 no 1505 0.463086610917541 503 6765896
SGTC_521 r062-0005 13.8 µM 0.0926011544719741 0.459028896074768 no 1506 0.463110213277481 504 2832033
SGTC_3200 9114385 49.47 µM 0.0913014657999413 0.459351893061006 no 1507 0.463626526657632 486 17018030 YLR208W SEC13
SGTC_641 4092-0595 30 µM 0.0912770113637298 0.459357970704441 no 1508 0.463636241999227 489 786260
SGTC_1436 4092-1007 8.32 µM 0.0880475509506057 0.460160669086716 no 1509 0.464919441336824 496 2881121
SGTC_2091 4-phenylthiadiazole 200 µM 0.0874383298163834 0.460312112323281 no 1510 0.465161551623361 504 270010
SGTC_500 h-89 112 µM 0.0824784818287429 0.461545268448704 no 1511 0.467133114519372 499 449241 Protein kinase A inhibitor; also known to inhibit several other kinases.
SGTC_1573 oleylamine 1.06 µM 0.0821921417412302 0.461616471961151 no 1512 0.467246961142707 515 5356789 An amine of the fatty acid oleic acid.
SGTC_1337 1486-1011 40.3 µM 0.0811059223660799 0.461886590731427 no 1513 0.467678857920215 512 X1337
SGTC_1907 st060210 83.7 µM 0.0807119654192357 0.461984563474901 no 1514 0.467835510418134 508 688793
SGTC_2310 7668677 200 µM 0.0792916266149292 0.462337805162717 no 1515 0.468400333163163 522 2197143
SGTC_1845 st056753 3.01 µM 0.0784210914403854 0.462554324062257 no 1516 0.468746548325557 513 5375839
SGTC_1648 st011736 69.8 µM 0.0772657478141703 0.462841697444542 no 1517 0.469206069353361 500 2855514
SGTC_956 1185-0240 191 µM 0.0771766133189282 0.462863869042704 no 1518 0.469241523007369 500 1416193
SGTC_2657 nystatin 74.44 µM 0.0768142027209835 0.46295401739622 no 1519 0.46938567599251 511 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_1163 k060-0048 49.9 µM 0.076576001086074 0.463013270246325 no 1520 0.469480425620299 514 6809982
SGTC_2513 baicalein 25.65 µM 0.0749639427721241 0.463414292564353 no 1521 0.470121700318934 507 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2
SGTC_1023 4482-3888 16 µM 0.0737763317779301 0.463709751412749 no 1522 0.470594180097829 518 3303168
SGTC_2003 4023581 200 µM 0.0722580495849622 0.464087505160922 no 1523 0.471198274484314 506 16641307
SGTC_887 0885-0007 9.62 µM 0.0720598441218704 0.464136821747408 no 1524 0.471277141429423 514 5719458
SGTC_2812 7970281 58.44 µM 0.0711020135252803 0.464375152574299 no 1525 0.471658282833709 499 2233435
SGTC_2763 lisinopril 49.32 µM 0.0702233574718059 0.464593794152574 no 1526 0.472007941820253 533 5362119 A lysine-analog of enalapril and an ACE inhibitor.
SGTC_834 0312-0008 75.7 µM 0.0701655730929084 0.464608173382754 no 1527 0.472030937728851 519 6385573 YIL048W NEO1
SGTC_2330 7979373 200 µM 0.0692990151810991 0.464823815666464 no 1528 0.472375804813299 512 1863007
SGTC_2723 salbutamol 83.58 µM 0.0691817576941787 0.464852995898769 no 1529 0.472422471782196 514 9884233 β2-adrenoceptor agonist
SGTC_1363 1636-0063 10.4 µM 0.0677654508496486 0.465205467276907 no 1530 0.472986173371929 514 6072185
SGTC_2630 antimycin a 100 µM 0.0667080778779901 0.465468629840115 no 1531 0.473407051711182 506 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain.
SGTC_585 0kpi-0023 191 µM 0.066236220826618 0.465586072100057 no 1532 0.473594880014759 511 64601
SGTC_88 0180-0332 8.668 µM 0.0647334784666957 0.465960115169886 no 1533 0.474193103376112 522 3101745
SGTC_2560 caryophyllene 100 µM 0.0635514159609998 0.466254359931188 no 1534 0.474663708968578 532 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor.
SGTC_3219 9131112 49.47 µM 0.0614710787789076 0.466772252305473 no 1535 0.475492023313102 516 17612988 YMR079W SEC14
SGTC_2493 resveratrol 26.09 µM 0.0610170004500443 0.466885300964491 no 1536 0.475672834940322 520 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase.
SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM 0.0609114610921162 0.46691157673238 no 1537 0.475714860882222 520 4620898
SGTC_728 3030-5151 22.5 µM 0.0606959849987362 0.466965223515612 no 1538 0.475800664647192 512 3125388
SGTC_2951 9072950 58.06 µM 0.0601160274726289 0.467109617712719 no 1539 0.476031612486242 524 16488155
SGTC_2589 lobaric acid 100 µM 0.0581120959112242 0.467608577255883 no 1540 0.476829669766415 510 73157 A novel microtubule depolymerizer.
SGTC_3020 9089140 49.47 µM 0.0549740704741657 0.468390017145742 no 1541 0.478079560654652 522 17217859
SGTC_1914 st062367 72.6 µM 0.0524304063091752 0.46902353705257 no 1542 0.479092873348797 514 978205
SGTC_2505 galangin 7.89 µM 0.0523948911880173 0.469032382936534 no 1543 0.479107022384559 528 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_772 k072-0172 35.3 µM 0.0513597701809738 0.469290211092327 no 1544 0.479519420592805 519 5861980
SGTC_2945 9067681 61.76 µM 0.0504287742690989 0.469522114751094 no 1545 0.479890353500128 527 16456930
SGTC_2131 toluylene red 5.2905 µM 0.0502838878751468 0.469558205728358 no 1546 0.479948081569794 514 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain.
SGTC_1151 3909-8316 15.3 µM 0.0468122257287846 0.470423065535555 no 1547 0.481331442497164 520 800431
SGTC_3197 9113331 49.47 µM 0.0464264199856551 0.470519186077557 no 1548 0.481485189554408 514 16610459 YLR208W | YDL195W SEC13 | SEC31
SGTC_298 1391-0729 10 µM 0.0460746738473566 0.470606822427294 no 1549 0.48162536595343 522 3237558
SGTC_2053 5265679 138 µM 0.0452231937751812 0.470818971666605 no 1550 0.481964703600483 522 764595
SGTC_663 1486-0733 13.9 µM 0.0444926394043762 0.471000998447745 no 1551 0.482255859536503 521 722445 YPR165W RHO1
SGTC_2126 5251174 33.877 µM 0.0440812906323931 0.471103493820334 no 1552 0.482419803099478 514 790722
SGTC_2319 6033012 152.6 µM 0.0436700893458009 0.471205954357199 no 1553 0.482583690853153 531 847246
SGTC_3029 9088683 49.47 µM 0.0429859128204293 0.471376437358766 no 1554 0.482856381707492 530 25236615
SGTC_2150 5556613 200 µM 0.0424624707806031 0.471506872109183 no 1555 0.483065014364723 521 743190
SGTC_511 blebbistatin 171 µM 0.0418918008218274 0.471649078906786 no 1556 0.483292476329077 505 3476986 A myosin inhibitor.
SGTC_3245 9134821 49.47 µM 0.0409986827863535 0.471871644665137 no 1557 0.483648472982498 530 17014901
SGTC_202 3594-0513 34.79 µM 0.0391822801454519 0.472324320741752 no 1558 0.484372530591262 535 708429
SGTC_2984 9022109 38.96 µM 0.0379763411305119 0.472624879474364 no 1559 0.48485327273019 527 6459207
SGTC_2098 5376439 882.5 nM 0.0378177642172044 0.472664403097344 no 1560 0.484916490353083 525 2844116
SGTC_2702 st077768 96.8 µM 0.0341724663753121 0.473573028555413 no 1561 0.486369811181348 527 6484119
SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM 0.033886291353512 0.47364436630769 no 1562 0.486483912413085 532 6708739 YPR165W RHO1
SGTC_3180 9109287 49.47 µM 0.0334054985160918 0.473764220319866 no 1563 0.486675612464825 529 18891271
SGTC_781 4335-2806 94.4 µM 0.0328469164141 0.473903468940833 no 1564 0.486898332245673 527 845254
SGTC_1272 0839-0021 27 µM 0.0303298772239375 0.474530979548204 no 1565 0.48790198447476 525 5027250
SGTC_3162 9099653 49.47 µM 0.0302292128061689 0.474556077021445 no 1566 0.487942125361301 541 25237511
SGTC_2205 7238770 200 µM 0.0302195659761832 0.474558482157209 no 1567 0.487945972132214 533 279867
SGTC_3280 9140961 49.47 µM 0.028475467426893 0.474993333809737 no 1568 0.488641467125273 538 4901226
SGTC_428 3448-4153 16.5 µM 0.028145406784773 0.475075630357698 no 1569 0.488773089512932 534 3834874
SGTC_2665 lovastatin 100 µM 0.0280229499023202 0.475106163740793 no 1570 0.488821923478851 530 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1
SGTC_381 3461-2219 42.7 µM 0.0269162709094384 0.475382109545741 no 1571 0.489263257955042 529 2883159
SGTC_1134 3477-0009 42.5 µM 0.0268644419399855 0.475395033174248 no 1572 0.48928392724806 540 3973534
SGTC_2470 5664817 21.68 µM 0.025025367091297 0.475853625803131 no 1573 0.490017364964729 534 2859561
SGTC_1349 flufenamic acid 69 µM 0.0249464968680241 0.4758732936413 no 1574 0.490048819811337 530 3371 A non-steroidal anti-inflammatory.
SGTC_2202 7226349 200 µM 0.0226318753046145 0.476450515932669 no 1575 0.49097195875926 531 844334
SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM 0.0223198730123519 0.476528327135692 no 1576 0.491096398229524 542 688798
SGTC_196 k015-0023 18.111 µM 0.0195117142653418 0.477228702331092 no 1577 0.492216446095144 542 5211998
SGTC_2713 st079149 53.4 µM 0.0180615378025461 0.477590414556642 no 1578 0.49279488066494 538 3103253
SGTC_2294 7971431 200 µM 0.0179817762154858 0.477610309736727 no 1579 0.492826695767486 539 5741572
SGTC_2436 5633522 8.09 µM 0.0157830695915763 0.478158761747924 no 1580 0.493703727632275 538 5724242
SGTC_1763 st044482 94.5 µM 0.0143648183122175 0.47851255663597 no 1581 0.494269463706438 543 88505
SGTC_967 1306-0166 352 µM 0.0136321206629092 0.478695340970151 no 1582 0.494561739132828 541 4437607
SGTC_252 miconazole 1.30953 nM 0.0133445886940675 0.478767072110682 no 1583 0.494676437357445 537 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_1039 k821-0043 94 µM 0.0127041954122285 0.478926834694227 no 1584 0.494931895641066 535 15992768
SGTC_997 3996-0078 137 µM 0.0123145381705573 0.479024046378836 no 1585 0.495087334226329 536 735687
SGTC_3191 9110352 49.47 µM 0.0120505627680691 0.479089903668864 no 1586 0.495192637360513 541 17122424
SGTC_2628 lathosterol 100 µM 0.0110491187332787 0.479339751783112 no 1587 0.495592129064005 536 6710616
SGTC_699 0375-0592 111 µM 0.0105221899543279 0.479471217374462 no 1588 0.49580233100347 544 762578
SGTC_1286 0929-0070 131 µM 0.0100353415630328 0.479592685133105 no 1589 0.495996545149058 545 1420408
SGTC_1571 st070080 73.4 µM 0.00896742088684578 0.479859135957111 no 1590 0.496422564608508 542 4315245
SGTC_2821 7996764 71.43 µM 0.00832954112529982 0.480018294015423 no 1591 0.496677032294098 543 2987135
SGTC_1173 0443-0020 122 µM 0.00738732865384311 0.480253392272894 no 1592 0.497052909065867 543 5331295
SGTC_862 0452-0056 10.2 µM 0.00711225849585254 0.480322028319161 no 1593 0.497162643297793 545 1575396 YLR359W | YHR072W ADE13 | ERG7
SGTC_2712 st079126 47.7 µM 0.00565339134676236 0.480686057420063 no 1594 0.497744635178017 545 3152970
SGTC_3193 9111931 49.47 µM 0.0046353792374202 0.480940090132571 no 1595 0.498150757858865 543 17087244
SGTC_723 4182-0001 115 µM 0.00241695432965138 0.481493698133782 no 1596 0.499035775666883 548 744821 YLR208W SEC13
SGTC_555 4296-0685 37 µM 0.00179590713277178 0.481648686920322 no 1597 0.499283537098195 547 2908540 YHR072W ERG7
SGTC_710 3448-4187 58 µM 0.000577853269919425 0.481952672962058 no 1598 0.49976946991159 547 3946412
SGTC_94 0334-0113 514.748 µM 0.00040260077149592 0.481996411069007 no 1599 0.499839385534467 548 6795178
SGTC_2324 6149169 200 µM -0.000107121011390825 0.482123624555705 no 1600 0.499957264899519 549 2888231
SGTC_2707 st078556 66.6 µM -0.00041450413011251 0.482200340380814 no 1601 0.499834636781832 549 17250899
SGTC_919 tnp00227 403.569 nM -0.00205325151754905 0.482609345456889 no 1602 0.499180871732904 550 1269246 A methoxyflavone. YNL221C POP1
SGTC_2429 5902844 64.44 µM -0.00234949782873218 0.482683285752819 no 1603 0.499062686840757 550 1927790 YGL093W | YPR107C SPC105 | YTH1
SGTC_1285 0929-0069 65.5 µM -0.00410855512596298 0.483122342109212 no 1604 0.498360928260211 550 1206237
SGTC_2480 5767542 37.17 µM -0.00552221088852437 0.483475201954863 no 1605 0.497796967792123 551 2867358
SGTC_767 0929-0023 86 µM -0.00644465867466704 0.483705459335306 no 1606 0.497428970969291 553 1204563
SGTC_37 0566-0070 1.56 µM -0.00708012187090998 0.483864084043946 no 1607 0.497175463633438 550 1626686
SGTC_245 methotrexate 289.6 µM -0.00866252085196316 0.484259094481424 no 1608 0.496544197397496 554 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2
SGTC_1215 3852-0577 11.2 µM -0.0115523730223329 0.484980520895792 no 1609 0.495391372471832 555 2884876
SGTC_2469 5655019 90.81 µM -0.0120503796914828 0.485104848953611 no 1610 0.495192710392202 551 2788239
SGTC_2357 9067248 200 µM -0.0122415529388364 0.485152576006065 no 1611 0.495116448926491 561 9150235
SGTC_2948 9070189 9.45 µM -0.0129067399878625 0.485318643872088 no 1612 0.494851098671133 554 6473636 YDL196W YDL196W
SGTC_1354 1498-1681 81 µM -0.0144932077989011 0.485714725133384 no 1613 0.494218249043508 555 5754243
SGTC_2345 9052315 157.45 µM -0.0175231274930345 0.486471220798114 no 1614 0.493009641303248 558 6469265
SGTC_1277 0873-0036 22 µM -0.0175286649763531 0.486472603415512 no 1615 0.493007432506275 558 5965735
SGTC_2750 bromebric acid 70.15 µM -0.0195610314703946 0.486980062339294 no 1616 0.492196775131165 567 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2
SGTC_2889 9059656 51.95 µM -0.0211550230386708 0.487378078795868 no 1617 0.491560996329953 561 3949838
SGTC_869 0564-0080 44.1 µM -0.0214693727560295 0.487456572778392 no 1618 0.491435617414781 559 6843321
SGTC_186 3455-3465 67.277 µM -0.0216174120152675 0.487493538754021 no 1619 0.491376571998768 554 755278
SGTC_76 0433-0009 400.328 µM -0.0233183454229582 0.487918276035013 no 1620 0.490698169080452 562 2841569
SGTC_1682 st012968 530 nM -0.024133422509425 0.488121812478677 no 1621 0.49037309188658 565 24207270
SGTC_2458 5808907 16.39 µM -0.0244914731579942 0.488211223844265 no 1622 0.490230292555334 559 2731747
SGTC_3007 9078383 71.4286 µM -0.0250435595080974 0.488349090399905 no 1623 0.490010109514425 566 6496995
SGTC_2148 5546263 113.568 µM -0.0277517535711985 0.489025398279768 no 1624 0.488930073098899 571 792097
SGTC_850 0388-0143 75.9 µM -0.0281536809284189 0.489125772936406 no 1625 0.488769789914752 562 67273
SGTC_2296 7971656 126.45 µM -0.0292056472551828 0.489388487232465 no 1626 0.488350288649011 564 666570
SGTC_471 1-acyl-paf 4 µM -0.0306805578569034 0.489756833841249 no 1627 0.487762148222798 563 16759367
SGTC_1393 3470-5649 58.2 µM -0.0309515458774233 0.48982451179622 no 1628 0.4876540909636 559 4108395
SGTC_420 mitomycin C 81.9 mM -0.0311271220797287 0.489868361264941 no 1629 0.487584079927008 559 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_2316 5844804 197.44 µM -0.033221531259068 0.490391441046762 no 1630 0.486748964068015 573 776813
SGTC_2200 6600604 21.907 µM -0.0357166827188809 0.491014627917705 no 1631 0.485754134076554 575 2904777
SGTC_1364 1653-0028 37.6 µM -0.0358783634573807 0.491055009932177 no 1632 0.485689674108865 557 5718652
SGTC_2165 5727197 32.143 µM -0.0379046762791431 0.491561117398514 no 1633 0.484881842299319 573 1361712
SGTC_2218 6965428 192.983 µM -0.0395268863587188 0.491966302888743 no 1634 0.48423515902397 561 675684
SGTC_2034 5197015 53.07 µM -0.0408393716343158 0.492294133340129 no 1635 0.483711975750995 573 780676
SGTC_1797 st048695 56.8 µM -0.0421779340513085 0.492628482657326 no 1636 0.483178426489965 563 592262 YIL048W NEO1
SGTC_3046 9092212 49.47 µM -0.0422156291188697 0.4926378982974 no 1637 0.483163401716028 560 25236637
SGTC_947 3447-0010 211 µM -0.0429241305895676 0.492814871673969 no 1638 0.482881006523033 577 748350
SGTC_550 4123-0385 25.7 µM -0.0437040861213618 0.493009694871187 no 1639 0.482570141038485 579 5731123
SGTC_1741 st038134 10.228 µM -0.0437471468020074 0.493020450942977 no 1640 0.482552978726764 574 1272587
SGTC_1866 st057638 64 µM -0.044335000137304 0.493167290572391 no 1641 0.482318686508709 571 688802
SGTC_2539 epi(13)torulosol 80 µM -0.0460007712563867 0.493583387779941 no 1642 0.481654817594086 580 6708597
SGTC_2377 9073351 62.6 µM -0.0468537565268464 0.493796459873032 no 1643 0.481314892265887 607 7337946 YHR072W ERG7
SGTC_2695 st077686 51.995 µM -0.0476876376156678 0.494004761534107 no 1644 0.480982593323939 580 2876092
SGTC_456 gingerol 170 µM -0.0498066121264058 0.494534083927731 no 1645 0.480138248754976 587 442793 A herb.
SGTC_1021 4476-0760 85.3 µM -0.0523702885167117 0.495174506166437 no 1646 0.479116823973659 581 746768
SGTC_1559 coumarin 343 70.1 µM -0.0553042286354206 0.495907437740686 no 1647 0.477948046680204 580 108770 A hepatotoxic, DNA x-linker.
SGTC_1523 st012844 44.7 µM -0.0562399495225633 0.496141194472722 no 1648 0.477575328195506 588 4274103
SGTC_1240 0356-0016 42.1 µM -0.0564102809744042 0.496183745899834 no 1649 0.477507483482475 577 4305613
SGTC_2732 terfenadine 20 µM -0.0564823530665776 0.496201750634574 no 1650 0.477478776646793 572 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.
SGTC_2825 7998094 58.44 µM -0.056532499574891 0.496214278020449 no 1651 0.477458802998704 584 2987815
SGTC_1293 1000-1278 195 µM -0.056726078113684 0.496262637016613 no 1652 0.477381700064079 586 678847
SGTC_706 4262-0057 46.9 µM -0.0576891182858554 0.496503220562593 no 1653 0.476998130805625 588 883298
SGTC_911 3456-4043 236 µM -0.0582583140171233 0.49664541578207 no 1654 0.476771435841346 570 914281
SGTC_592 k241-0073 46.5 µM -0.0582662281901671 0.496647392886333 no 1655 0.476768283897272 569 4230158
SGTC_3003 9075612 71.4286 µM -0.0594475898616598 0.496942519399237 no 1656 0.476297804413916 594 6501993
SGTC_3336 9143619 71.43 µM -0.0608498934288897 0.497292843539851 no 1657 0.475739377349445 581 45595730
SGTC_1808 st050063 61.5 µM -0.0610725149313637 0.497348459147907 no 1658 0.475650729093252 571 4011993
SGTC_2985 9022375 71.43 µM -0.0617859791355392 0.49752669809252 no 1659 0.475366634591407 614 4939335
SGTC_973 1325-0077 65.9 µM -0.0618173503317583 0.497534535314266 no 1660 0.47535414317279 574 2835149
SGTC_1051 3253-3903 78 µM -0.0630573851574171 0.497844324292876 no 1661 0.474860404223913 566 5509239
SGTC_1835 st008666 49.2 µM -0.0634040043513941 0.497930917912709 no 1662 0.474722399328978 582 690455
SGTC_2511 berberine 10.47 µM -0.0637031046718034 0.498005640279786 no 1663 0.474603316299941 579 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_478 N-arachidonylglycine 10 µM -0.0641375994341797 0.498114187519565 no 1664 0.474430331722373 576 5283389
SGTC_2276 7947513 42.08 µM -0.0665487619195541 0.498716556204381 no 1665 0.473470468661632 615 2105100
SGTC_2253 7938677 135.83 µM -0.0673566693301175 0.498918392401452 no 1666 0.47314888183718 594 2301972
SGTC_2381 9035592 200 µM -0.0674476526684096 0.498941122414253 no 1667 0.473112667092958 603 4749657
SGTC_906 1165-0455 526 µM -0.0674885830678125 0.498951347897536 no 1668 0.473096375347891 605 3252859
SGTC_1626 st003712 1.76 µM -0.0681873909577244 0.499125928469044 no 1669 0.47281823208387 600 24207035
SGTC_395 anisomycin 6.25 µM -0.0684912934672684 0.499201851354909 no 1670 0.472697275304342 601 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_119 0121-0043 24.815 µM -0.0687104561405291 0.49925660400619 no 1671 0.472610047539957 579 1092378
SGTC_2870 9038528 12.99 µM -0.0689277525768294 0.499310890435784 no 1672 0.472523563843363 611 6463316
SGTC_532 1548-0774 215 µM -0.0691891137310435 0.499376185420791 no 1673 0.472419544163173 617 5932993
SGTC_1633 st005664 67.9 µM -0.0705816743545606 0.499724084433632 no 1674 0.471865347889378 595 2063822
SGTC_2113 5491891 107.031 µM -0.0706409653770911 0.499738896928654 no 1675 0.471841753088376 598 789979
SGTC_1510 1123-0200 71.5 µM -0.0706432091679316 0.499739457488072 no 1676 0.471840860176075 607 5378812 YNL149C | YNL150W PGA2 | YNL150W
SGTC_112 phenothiazine 287.218 µM -0.0714484551996521 0.499940629671388 no 1677 0.471520423222284 584 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.
SGTC_2096 5468907 200 µM -0.071494121878189 0.499952038440655 no 1678 0.471502251325077 570 759785
SGTC_2068 5226020 147 µM -0.0718780800505447 0.499952038440655 no 1679 0.471349467252743 594 1810509
SGTC_484 loperamide 105 µM -0.0736262584775787 0.499515296385181 no 1680 0.470653888298113 573 3955 An opioid-receptor agonist.
SGTC_2295 7971645 200 µM -0.073723018695227 0.499491123088883 no 1681 0.470615391178421 593 2978226 YKL099C UTP11
SGTC_347 4534-1311 26.2 µM -0.0750965095710645 0.499147988491402 no 1682 0.470068962471787 580 2862016
SGTC_930 2810-3379 265 µM -0.0756512153411261 0.499009408382355 no 1683 0.469848294612117 624 1015764
SGTC_798 1287-0182 476 µM -0.077137852244578 0.498638007970228 no 1684 0.469256940478449 617 1649755
SGTC_2368 9071271 200 µM -0.078755435521408 0.498233895113373 no 1685 0.468613575598164 604 27209959
SGTC_758 0868-0029 16 µM -0.0792667103991347 0.498106166188038 no 1686 0.468410242106351 576 762687
SGTC_2685 mycophenolic acid 18.85 µM -0.0813504229858871 0.497585606145988 no 1687 0.467581637546054 578 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_1840 st055363 71 µM -0.0823452360690079 0.49733708001234 no 1688 0.4671860916779 602 676033
SGTC_2112 5488546 200 µM -0.0824064413916769 0.497321789612698 no 1689 0.467161756992028 593 600757
SGTC_731 3966-0296 387 µM -0.0833193489456241 0.497093726245201 no 1690 0.466798807776331 596 660956
SGTC_2455 5377712 9.75 µM -0.0836899968116386 0.497001130936436 no 1691 0.466651455315506 582 2243908
SGTC_1388 3346-4487 254 µM -0.0845683675623834 0.496781696870145 no 1692 0.466302273989129 604 3345614
SGTC_1458 k015-0034 6.33 µM -0.0852417261573814 0.496613479476322 no 1693 0.46603460930115 621 3598957
SGTC_2259 7964009 200 µM -0.0855845183364796 0.496527843898277 no 1694 0.465898352938213 595 313134
SGTC_128 0906-2981 13.371 µM -0.0890365205130332 0.495665481992732 no 1695 0.464526443096089 599 6740226
SGTC_233 rapamycin 362 pM -0.0890824806451976 0.495654000590248 no 1696 0.464508180226801 583 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C
SGTC_2388 9080168 200 µM -0.0915212092230139 0.495044781799067 no 1697 0.463539227216994 594 15943073
SGTC_518 1021-0119 62.6 µM -0.092936435381757 0.494691249357318 no 1698 0.462977029873633 610 1097762
SGTC_2082 5219693 150 µM -0.0932580759422531 0.494610902083345 no 1699 0.462849268716198 598 2834649
SGTC_1771 st048882 4.1505 µM -0.094140842082076 0.494390384222303 no 1700 0.462498638568201 592 4580403
SGTC_841 0251-0215 91.2 µM -0.0952382861220405 0.494116241519367 no 1701 0.462062780126647 606 3888614
SGTC_1005 4092-0690 4.4 µM -0.0956220661011156 0.494020373516484 no 1702 0.461910369644912 613 1529343
SGTC_1694 st024011 44.9 µM -0.0963658388906103 0.493834580518968 no 1703 0.461615011218907 615 2787533
SGTC_1756 st041558 35.5 µM -0.0966548148571044 0.493762395242616 no 1704 0.461500262135005 623 3955792
SGTC_1982 st072467 71.9 µM -0.0969246466728507 0.493694992298522 no 1705 0.461393117869932 611 3163533
SGTC_2023 5144124 124 µM -0.0978502432321649 0.493463783237071 no 1706 0.461025605222499 581 2830192
SGTC_3179 9107801 49.47 µM -0.0998452816101205 0.492965440907751 no 1707 0.460233579056841 589 4818259
SGTC_837 0091-0265 12.5 µM -0.0999221799889431 0.492946232611208 no 1708 0.46020305369477 598 759367
SGTC_1564 D-Arginine 115 µM -0.100768857639555 0.492734743738181 no 1709 0.459866974486837 626 71070 D-isomer of arginine; arginine decarboxylase inhibitor.
SGTC_881 0833-0569 170 µM -0.101313139590184 0.492598790384043 no 1710 0.459650942989715 586 5418700
SGTC_2021 4019055 173 µM -0.102184073298078 0.492381246183545 no 1711 0.459305284622365 610 44827708 YER133W GLC7
SGTC_2369 9071472 200 µM -0.102844106183418 0.492216382872453 no 1712 0.459043349580925 594 17296037
SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM -0.103645716738991 0.492016158017859 no 1713 0.458725253148697 608 4213774
SGTC_3306 9127676 59.7925 µM -0.104645576385641 0.491766417684125 no 1714 0.458328524245667 596 41905287
SGTC_1014 4130-3005 69.3 µM -0.106702422726944 0.491252678343089 no 1715 0.457512530262088 607 743608
SGTC_1669 st015249 58.4 µM -0.109550028768584 0.49054145476259 no 1716 0.456383121644532 600 722793
SGTC_645 0845-0943 5.41 µM -0.112124461834279 0.489898485212598 no 1717 0.455362360991362 603 1885106
SGTC_1760 st045453 10.4495 µM -0.112993012175301 0.489681568953103 no 1718 0.45501804760542 598 3323419 YIL048W NEO1
SGTC_2804 7954240 19.48 µM -0.113358184484892 0.489590369837254 no 1719 0.45487329495501 605 828705
SGTC_2857 9024691 58.44 µM -0.113563960991061 0.48953897889798 no 1720 0.454791728717866 636 16478292
SGTC_2691 st077356 60.2 µM -0.113629905977434 0.489522509732961 no 1721 0.454765589672444 612 2839272
SGTC_545 4218-0007 221 µM -0.116200969011359 0.488880424153398 no 1722 0.453746634398292 616 2840508
SGTC_1075 aripiprazole 15.2 µM -0.118096149497353 0.488407148761713 no 1723 0.452995737179717 603 60795 An atypical antipschotic. YIL048W NEO1
SGTC_1799 st045822 46.1415 µM -0.118490452370131 0.488308683205574 no 1724 0.452839529854218 600 3674992
SGTC_1925 st057770 10.1 µM -0.118936050009785 0.48819740914669 no 1725 0.452663010340031 612 5989122
SGTC_799 1310-0557 151 µM -0.119931881445538 0.487948734758798 no 1726 0.452268554501146 642 5354492
SGTC_732 3970-1727 52.7 µM -0.120320622774617 0.487851661350866 no 1727 0.452114584088083 599 1275699
SGTC_1297 1068-0111 14.1 µM -0.120793116357947 0.487733674962441 no 1728 0.451927451265705 591 767057
SGTC_2389 9091542 195.52 µM -0.121570097433382 0.487539657331278 no 1729 0.45161974829242 603 3626624 YOL127W RPL25
SGTC_173 1273-0061 2.693 µM -0.123604567231783 0.48703165002218 no 1730 0.450814188046912 611 2847414 YPL266W DIM1
SGTC_1917 st066507 28.5 µM -0.124706266537592 0.486756564327031 no 1731 0.450378048077118 610 3156428
SGTC_206 4546-0025 72.014 µM -0.125560968783427 0.48654315619864 no 1732 0.450039730380956 648 6620745 YIL048W NEO1
SGTC_667 1498-1044 59 µM -0.126160596418801 0.486393439207493 no 1733 0.449802400793696 601 6739982
SGTC_2401 5128683 200 µM -0.126634137247765 0.486275205337222 no 1734 0.449614988410355 642 708373
SGTC_131 0141-0277 33.849 µM -0.128089998229258 0.485911712965698 no 1735 0.449038875551958 628 1547771
SGTC_230 MPP+ 141.667 µM -0.129014249349864 0.485680956443989 no 1736 0.448673186854608 621 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death.
SGTC_3158 9100007 49.47 µM -0.129131529922928 0.485651675503839 no 1737 0.448626786797721 611 19297233
SGTC_1235 benzylparaben 21.5 µM -0.130051769822625 0.485421925832929 no 1738 0.448262734027292 633 7180
SGTC_1408 3909-7976 48.8 µM -0.130345319432385 0.485348638429527 no 1739 0.44814661308129 609 24152374
SGTC_2298 7976326 193.81 µM -0.130507301845515 0.485308198218031 no 1740 0.448082538757237 602 2235818
SGTC_1208 2323-2347 50.3 µM -0.132802187511496 0.484735277995497 no 1741 0.447174912150675 624 5412760
SGTC_2824 7998404 51.95 µM -0.1329489789363 0.484698632447042 no 1742 0.447116865546629 591 837851
SGTC_1203 3992-3522 103 µM -0.133899923531895 0.484461238302391 no 1743 0.446740855377176 658 5322312
SGTC_533 1222-0222 6.71 µM -0.133971920459851 0.484443265187098 no 1744 0.446712389231738 629 3982874
SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM -0.135616786258812 0.484032654090227 no 1745 0.446062117271368 659 6710655
SGTC_2192 5915882 198.485 µM -0.137085155165212 0.483666116552581 no 1746 0.445481743075231 610 2876149
SGTC_192 3455-0609 60.9 µM -0.137937602510429 0.483453333048351 no 1747 0.44514486597047 619 3769639
SGTC_1231 0242-0792 125 µM -0.13930259411171 0.48311262073357 no 1748 0.444605520032463 631 3707635
SGTC_749 1000-0129 128 µM -0.141857376112717 0.48247496099374 no 1749 0.443596331341659 635 708470
SGTC_2649 anisomycin 9.56 µM -0.144877967941722 0.48172109560612 no 1750 0.442403610961574 637 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_2819 7996655 46.38 µM -0.145512181714336 0.481562819667467 no 1751 0.442153249248646 625 6456960
SGTC_2133 5320837 200 µM -0.146786701406324 0.481244756232796 no 1752 0.441650190859393 635 2841355
SGTC_1876 myriocin 605 nM -0.148465448696829 0.480825833817734 no 1753 0.440987725839203 612 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1
SGTC_345 1362-0200 395 µM -0.15166754851531 0.480026826021369 no 1754 0.439724576775316 628 1419823
SGTC_307 1501-1223 22.3 µM -0.152159500109771 0.479904078240929 no 1755 0.439530568090739 632 2830329
SGTC_1977 st070720 65.3 µM -0.153069928906772 0.479676920451049 no 1756 0.439171564819137 632 682188
SGTC_1834 st055981 52.8 µM -0.153148895927539 0.479657217985876 no 1757 0.43914042863789 641 471719 YDL150W RPC53
SGTC_2030 5175110 200 µM -0.156678821641411 0.478776544355268 no 1758 0.437748989399525 657 2831986
SGTC_423 5-fluorouracil 457 µM -0.157044308048153 0.478685365777786 no 1759 0.437604964273053 619 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_2983 9022671 12.99 µM -0.159086537862344 0.478175907551023 no 1760 0.436800347187234 667 6405161
SGTC_3008 9078912 71.4286 µM -0.159109726938678 0.478170122966599 no 1761 0.436791212429407 646 16648731
SGTC_2788 5282734 71.43 µM -0.160535777997669 0.477814399150651 no 1762 0.436229520161345 654 743706
SGTC_2432 5630864 12.22 µM -0.1607420744612 0.477762940622969 no 1763 0.43614827483397 642 5714970
SGTC_1893 st059353 36.1 µM -0.161267126656449 0.477631973436199 no 1764 0.435941506730525 682 3112488
SGTC_2170 morpholine 200 µM -0.161545871068646 0.477562445383785 no 1765 0.43583174293854 634 121171 Reacts with secondary amines.
SGTC_2081 5214970 32.255 µM -0.161986691095363 0.47745249172098 no 1766 0.435658167209369 628 2063512
SGTC_1145 3546-0597 10.2 µM -0.163047684551117 0.477187855360482 no 1767 0.435240445069824 619 875334
SGTC_1736 st036774 51 µM -0.163236233156583 0.477140828017271 no 1768 0.435166219429785 671 1272247
SGTC_1221 2958-7315 257 µM -0.166054288686795 0.476437993628995 no 1769 0.434057113488216 633 4562705
SGTC_175 3793-3120 23.7 µM -0.168345603142498 0.475866584508026 no 1770 0.433155699820239 666 5322297
SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM -0.169651866725283 0.475540849991405 no 1771 0.432641964996355 612 2333 A French combination drug.
SGTC_125 0133-0007 11.75 µM -0.170092848048457 0.475430889005538 no 1772 0.432468558995025 629 26541
SGTC_1447 4239-0816 81.9 µM -0.170291178019882 0.475381435005479 no 1773 0.432390574426282 630 1341554
SGTC_1355 1499-0035 1.68 µM -0.17034611509633 0.475367736395707 no 1774 0.432368973294477 626 1548538
SGTC_2573 2',4'-dihydroxychalcone 15.04 µM -0.170802469943612 0.475253945028228 no 1775 0.432189543440754 643 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_73 0327-0325 16.231 µM -0.171304392011222 0.475128793876773 no 1776 0.431992213593066 634 53298
SGTC_2219 9098279 200 µM -0.171933907473612 0.474971831574906 no 1777 0.431744744598261 615 902349
SGTC_3273 9137859 49.47 µM -0.172479921621887 0.474835692491861 no 1778 0.431530122514391 612 2377234
SGTC_357 1325-0123 420 µM -0.172872499106476 0.474737811973452 no 1779 0.431375824351308 665 1098503
SGTC_3189 9110682 49.47 µM -0.174051324693589 0.474443907056601 no 1780 0.43091256324025 647 17122418
SGTC_2633 5,7-dihydroxyisoflavone 100 µM -0.176337797725057 0.473873883156431 no 1781 0.430014284486028 635 5377381
SGTC_1172 0370-0043 85 µM -0.179460692298833 0.473095423750881 no 1782 0.428787989616166 635 376585
SGTC_991 3996-0057 64.7 µM -0.179730552720942 0.473028159086497 no 1783 0.428682053202798 620 715343
SGTC_2445 5742597 35.57 µM -0.183056690108293 0.472199159008588 no 1784 0.427376768885051 621 1774255
SGTC_1798 st045719 60.953 µM -0.184312263290801 0.471886253480855 no 1785 0.426884247009855 612 3980186
SGTC_469 w7 172 µM -0.184724006198477 0.471783645443551 no 1786 0.426722757993038 627 45115570 A P450 inhibitor.
SGTC_1400 3771-8998 51.5 µM -0.186876216995897 0.471247336236696 no 1787 0.42587884338818 618 670767
SGTC_1074 carmofur 3.8 µM -0.188168041194409 0.470925451663162 no 1788 0.425372462195402 635 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_1889 st059080 5.18 µM -0.18836077038358 0.470877430844125 no 1789 0.425296924956836 646 176925 Isolated from Daphnopsis sellowiana.
SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM -0.188584720169768 0.470821631565985 no 1790 0.425209154730544 609 4000243
SGTC_2989 9073649 71.4286 µM -0.191213001847929 0.470166812601139 no 1791 0.424179358777279 651 21367202
SGTC_526 4469-0568 170 µM -0.192180019384592 0.46992590679546 no 1792 0.423800598199871 634 2901964
SGTC_65 0798-0905 34.986 µM -0.193707662420644 0.469545359040382 no 1793 0.423202395872033 738 3602145
SGTC_390 dec-rvkr-cmk 16.7 µM -0.194646042298447 0.469311615087989 no 1794 0.422835027912424 642 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1
SGTC_2321 7390090 138.78 µM -0.195533161818096 0.469090649461163 no 1795 0.422487789650535 658 649046
SGTC_965 1291-5240 308 µM -0.195579926497646 0.469079001478348 no 1796 0.422469486586247 651 2834598
SGTC_436 n,n-dimethylsphingosine 3.3 µM -0.195703944418161 0.469048111656661 no 1797 0.422420948457046 675 5282309
SGTC_2884 9058502 51.95 µM -0.19753339113906 0.468592463101205 no 1798 0.421705076912154 656 6471554
SGTC_2908 7930301 100 µM -0.198491940992631 0.468353739626078 no 1799 0.421330094735749 647 2223178
SGTC_195 4234-0266 16.654 µM -0.199288637099931 0.468155333913474 no 1800 0.421018483591423 644 2303354
SGTC_1660 st012960 28.1 µM -0.19947283015852 0.468109464404042 no 1801 0.420946447334116 656 24207266
SGTC_2703 st077852 53.4 µM -0.199793178159182 0.468029689303267 no 1802 0.420821168402846 666 6281836
SGTC_2515 chrysin 20.77 µM -0.200775086898477 0.467785176143313 no 1803 0.420437222013451 641 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor.
SGTC_115 0527-0192 112.043 µM -0.203125810187491 0.46719985278038 no 1804 0.419518349309942 652 4233931
SGTC_1316 1272-0050 65.9 µM -0.204228675658355 0.466925266802446 no 1805 0.419087401818185 640 7340392
SGTC_2204 7233102 200 µM -0.204846705618674 0.466771399639853 no 1806 0.41884594743787 653 2172480
SGTC_2117 5521686 200 µM -0.204972063184395 0.466740190733704 no 1807 0.418796975975991 638 803312
SGTC_1366 1683-0113 21.9 µM -0.205158416339312 0.466693796798855 no 1808 0.418724178655726 645 708623
SGTC_1141 3253-0389 52.6 µM -0.207102046432328 0.466209943442535 no 1809 0.417965081962013 616 5402031
SGTC_832 4083-0019 164 µM -0.208476344164375 0.465867851562128 no 1810 0.417428525737148 632 1990758
SGTC_392 N-ethylmaleimide 8.33 µM -0.209661206486817 0.465572934411348 no 1811 0.416966052635032 623 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides.
SGTC_3126 9127922 49.47 µM -0.211010875885663 0.465237019138366 no 1812 0.41643939234969 676 45595682
SGTC_1951 sophoraflavanone G 9.2 µM -0.211247065277704 0.465178237190631 no 1813 0.416347243266468 648 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity.
SGTC_2213 7173844 200 µM -0.211354049088233 0.465151611703065 no 1814 0.416305505139655 622 892728
SGTC_1327 1436-0082 2.18 µM -0.213352641074288 0.464654242955104 no 1815 0.415525958483292 649 15992205
SGTC_1326 1431-2094 10.8 µM -0.216221863825274 0.463940306146865 no 1816 0.414407405878588 665 616278
SGTC_3275 9138069 49.47 µM -0.21665095253124 0.463833547705792 no 1817 0.414240187139299 630 17617007
SGTC_1932 st074806 40.9 µM -0.217339780841837 0.463662170791256 no 1818 0.413971778657221 633 17251235
SGTC_563 tetrahydrosecaminediol 614 µM -0.217781234916166 0.463552342848271 no 1819 0.413799783010885 654 334274 A psychoactive constituent of the cannabis plant.
SGTC_3214 9129694 49.47 µM -0.220522049525811 0.462870526856109 no 1820 0.412732300986831 661 17158655
SGTC_1477 0139-0234 16 µM -0.221247023806802 0.462690197515526 no 1821 0.412450048324242 634 620880
SGTC_1575 cyproterone acetate 48 µM -0.222450758406518 0.462390798789179 no 1822 0.411981500997771 681 9880 An androgen receptor antagonist and liver toxin.
SGTC_2305 7443522 69.23 µM -0.224048631996104 0.461993400838114 no 1823 0.411359731046965 650 5415886
SGTC_922 1866-0035 480 µM -0.22493277907372 0.461773525982148 no 1824 0.411015784305652 673 3156169
SGTC_979 1426-2828 121 µM -0.225462124954005 0.461641890745646 no 1825 0.410809893375008 655 747872
SGTC_2927 9011802 47.9 µM -0.226569417763553 0.46136654799799 no 1826 0.41037928748697 654 43912568
SGTC_2975 9084847 53.72 µM -0.228243130596443 0.460950392741654 no 1827 0.409728616420542 634 27211724
SGTC_1456 k015-0012 13 µM -0.230673245463496 0.460346240429478 no 1828 0.408784330021194 671 2989616
SGTC_1636 st007707 68.9 µM -0.230789694582317 0.46031729223138 no 1829 0.408739093833016 689 403051
SGTC_833 3852-0053 558 µM -0.233020499429554 0.459762775101841 no 1830 0.407872743818279 669 3123681
SGTC_1339 1486-1321 22.7 µM -0.236776631594144 0.458829280648284 no 1831 0.406415040697987 660 3469382
SGTC_141 0443-0274 32.331 µM -0.237227265105798 0.45871730189825 no 1832 0.406240242720369 656 1627241
SGTC_648 0375-0473 33.3 µM -0.237941764321037 0.458539761392367 no 1833 0.405963131166978 660 1713139
SGTC_1140 3229-1848 2.98 µM -0.238777415262236 0.458332127305701 no 1834 0.40563909187377 676 2849525
SGTC_2347 9049783 174.81 µM -0.239198619084768 0.458227475149604 no 1835 0.40547578670047 700 6467988 YPL169C MEX67
SGTC_2834 9001755 58.44 µM -0.241259166993525 0.457715553995109 no 1836 0.404677128123821 685 2989575
SGTC_3074 9116018 49.47 µM -0.241876178838491 0.457562277589788 no 1837 0.40443805434484 647 17027303
SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM -0.242096260826846 0.457507606946504 no 1838 0.404352787733564 692 5393153
SGTC_1592 4',5'-dihydroxyflavone 8.85 µM -0.242136486651322 0.457497614522336 no 1839 0.404337203488271 668 688669
SGTC_702 1488-0190 94 µM -0.242533642698377 0.457398959151495 no 1840 0.40418334587464 640 949357
SGTC_631 k072-0230 41.5 µM -0.24290792431386 0.457305988296176 no 1841 0.404038363342296 674 5773147
SGTC_487 nimodipine 119 µM -0.243628228593931 0.457127072635632 no 1842 0.403759381833784 662 4497 L-type voltage-gated calcium channels inhibitor
SGTC_3049 9092223 49.47 µM -0.24505834794969 0.456771872505638 no 1843 0.40320562661224 686 8623917
SGTC_2373 9071805 200 µM -0.245564142814502 0.456646255997505 no 1844 0.403009824633729 695 10149009
SGTC_2977 9011197 71.43 µM -0.247621434794763 0.456135362740389 no 1845 0.402213662282636 651 2704722
SGTC_3315 9136395 68.55 µM -0.247649323534138 0.456128437545476 no 1846 0.402202872249751 719 16876844
SGTC_647 0140-0236 81 µM -0.247956367085814 0.456052194878909 no 1847 0.402084083353376 666 990837
SGTC_901 1112-0062 60.1 µM -0.248309706711102 0.455964458334185 no 1848 0.401947394641339 646 1908457
SGTC_2481 5478948 45.16 µM -0.248906283525336 0.455816329276669 no 1849 0.401716637344899 651 77792
SGTC_27 0485-0001 32.618 µM -0.249524277337856 0.455662888889498 no 1850 0.40147763203492 647 2054479
SGTC_1774 st048371 48.465 µM -0.250242379443769 0.455484601132331 no 1851 0.40119995675435 647 4242727
SGTC_2211 7117706 200 µM -0.250387292731629 0.455448623678615 no 1852 0.401143927819213 637 822771
SGTC_1320 1313-0481 95.3 µM -0.250507158756947 0.455418864955768 no 1853 0.401097584635351 671 6813365 YLR208W SEC13
SGTC_1043 0916-0009 19.3 µM -0.252018220892723 0.45504374030176 no 1854 0.400513490014489 702 3101130
SGTC_1431 4049-0260 9.09 µM -0.252084373278824 0.455027318733013 no 1855 0.400487924163904 657 3854841
SGTC_265 mycophenolic acid 32.932 µM -0.254189556980774 0.454504771386172 no 1856 0.399674559016874 680 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1
SGTC_894 0960-0238 55.9 µM -0.254244931279519 0.454491027471982 no 1857 0.399653170293722 672 6741907 YDL195W SEC31
SGTC_2050 5263056 171 µM -0.257971994680362 0.453566095521342 no 1858 0.398214260433835 674 763468 YGL055W OLE1
SGTC_2411 st077133 39.94 µM -0.259096658026482 0.453287041082243 no 1859 0.397780331644561 716 1403142 YNL221C POP1
SGTC_1282 0886-0010 32.4 µM -0.260538149897604 0.452929408057788 no 1860 0.397224345862415 659 2836211 YNL267W PIK1
SGTC_3014 9081533 49.47 µM -0.260823467996731 0.452858625373873 no 1861 0.397114322919424 699 21367265
SGTC_2247 cerulenin 830 nM -0.26151136707779 0.452687975195104 no 1862 0.396849092387103 638 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12
SGTC_661 1304-0007 33.6 µM -0.262100926575419 0.452541727506055 no 1863 0.396621816221203 664 3117130
SGTC_1416 3966-0321 25.3 µM -0.263374500266099 0.452225823448235 no 1864 0.396130971411352 675 582530 YLR208W SEC13
SGTC_2121 5257820 149.641 µM -0.263659723629006 0.452155079251375 no 1865 0.39602106673271 661 791256
SGTC_2517 totarol 10 µM -0.263895073720352 0.452096706308851 no 1866 0.395930385867895 668 460178 An antibacterial membrane disruptor. YGL001C ERG26
SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM -0.264017115260447 0.452066437241057 no 1867 0.395883365233471 677 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_1391 3442-0225 151 µM -0.266743548368954 0.451390293003326 no 1868 0.394833310783567 644 5227075
SGTC_2873 9040596 71.43 µM -0.270504368799128 0.450457856735879 no 1869 0.393386128175263 729 6463863
SGTC_3115 9123671 49.47 µM -0.270902286281795 0.450359215258926 no 1870 0.393233093280043 656 3286988
SGTC_791 1348-1292 225 µM -0.271108839939902 0.450308012992456 no 1871 0.393153661409358 694 5437054
SGTC_677 0929-0063 136 µM -0.273373071936765 0.449746790438945 no 1872 0.392283225086763 668 1539583
SGTC_1938 st074717 56.4 µM -0.275981250416873 0.449100440414571 no 1873 0.391281233595724 650 17250979
SGTC_3332 9141069 11.198 µM -0.279362384891623 0.448262740289929 no 1874 0.389983367430354 666 17332883
SGTC_2064 5220758 200 µM -0.279578390807996 0.448209231085999 no 1875 0.389900493924943 666 788518
SGTC_1721 st082152 9.2685 µM -0.279988982524228 0.448107521489765 no 1876 0.389742978823751 665 5296051
SGTC_770 0389-1121 67.2 µM -0.280291954046358 0.448032473182543 no 1877 0.389626761614118 651 6753108
SGTC_3296 9122258 64.045 µM -0.281139050041739 0.447822651061352 no 1878 0.389301875446762 684 4730474
SGTC_2871 9038510 12.99 µM -0.281354707814522 0.447769235865653 no 1879 0.389219176709954 730 4945164
SGTC_3061 glucosamine 200 µM -0.28172668144476 0.447677105802908 no 1880 0.38907654699794 657 91431 and experimental redox chemotherapeutic
SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM -0.284834860035835 0.446907385994751 no 1881 0.387885331763308 657 5355888
SGTC_1128 3448-9350 235 µM -0.285477385685701 0.44674829362502 no 1882 0.38763921374214 655 619386
SGTC_528 3492-0019 172 µM -0.286835478003006 0.446412051817989 no 1883 0.387119148156088 638 2869262
SGTC_2888 9058547 12.99 µM -0.287526850214301 0.446240893965677 no 1884 0.386854472993438 664 16476514
SGTC_2730 imipramine 71.33 µM -0.287683422115302 0.446202134019909 no 1885 0.386794540522473 681 3696 A tricyclic antidepressant.
SGTC_665 3914-0008 307 µM -0.287888627208569 0.44615133552823 no 1886 0.386715996363511 694 1069549
SGTC_515 4092-1064 102 µM -0.287958074879052 0.446134143967395 no 1887 0.386689415672115 725 717353
SGTC_3320 9137005 35.139 µM -0.291069890647453 0.445363927781469 no 1888 0.385498933599404 689 4908713
SGTC_1097 itavastatin 7.23 µM -0.292315866575616 0.445055589651327 no 1889 0.385022564287015 659 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49
SGTC_1746 st038117 42 µM -0.292444925447671 0.445023653714759 no 1890 0.384973231594722 656 2898218
SGTC_1668 st014914 51.6 µM -0.293056894956003 0.444872225209659 no 1891 0.384739331901245 669 2839556
SGTC_727 3032-0951 202 µM -0.293412295640869 0.444784286946695 no 1892 0.384603514133957 687 3652836
SGTC_855 0428-0020 25 µM -0.293972108916619 0.444645775543107 no 1893 0.384389608021484 664 6812414
SGTC_2673 kobusone 100 µM -0.298461846592159 0.443535151270055 no 1894 0.382675345918252 668 6710676 An epoxy ketone and protein crosslinker.
SGTC_497 capsazepine 133 µM -0.301343326063657 0.442822594104853 no 1895 0.381576352991922 653 2733484 A calcium channel blocker.
SGTC_1788 fluconazole 20 µM -0.301725425312292 0.442728119132993 no 1896 0.38143069223148 713 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11
SGTC_2891 9063876 19.48 µM -0.302047523547032 0.442648482087624 no 1897 0.381307917611459 672 6472478
SGTC_460 trequinsin 123 µM -0.302726957093255 0.442480503423457 no 1898 0.381048976191456 663 5537 A vasodilator.
SGTC_98 0074-0023 107.663 µM -0.305130270586265 0.441886407242116 no 1899 0.38013346862085 708 3563821
SGTC_1220 1838-0075 193 µM -0.30584565766691 0.441709589605753 no 1900 0.379861081643217 676 5529645
SGTC_1446 4239-0190 62 µM -0.308359947767558 0.441088241026477 no 1901 0.378904227529035 700 1340085
SGTC_1528 arabinosylhypoxanthine 74.6 µM -0.30969510937758 0.440758345590905 no 1902 0.378396411104823 707 804 An inhibitor of viral and cellular DNA polymerases.
SGTC_1988 st071872 53.4 µM -0.309776576985425 0.440738217676703 no 1903 0.378365432437653 685 16414116
SGTC_359 0081-0058 15.9 µM -0.310707134082398 0.440508319095426 no 1904 0.378011636653579 724 3494159
SGTC_2383 9036125 200 µM -0.310779066908534 0.440490548580649 no 1905 0.377984292204691 689 79580
SGTC_1687 st020778 55.3625 µM -0.311184336127031 0.440390431821263 no 1906 0.377830245130146 675 4259299
SGTC_2680 butyl paraben 22.24 µM -0.311985872605796 0.440192433352622 no 1907 0.377525629946168 679 7184 An antifungal and steroid mimetic.
SGTC_2456 5770359 74.46 µM -0.312204222256138 0.440138498414252 no 1908 0.377442661739332 719 3118787
SGTC_2483 5729050 27.16 µM -0.314138832507672 0.439660675502163 no 1909 0.376707798591726 712 2865180
SGTC_1123 mangostin 811.285 nM -0.316189706566514 0.439154232960563 no 1910 0.37592926012454 670 5281650 An antioxidant.
SGTC_933 2914-0560 114 µM -0.316477907075623 0.43908307273003 no 1911 0.375819895839439 690 463887
SGTC_1030 k029-0042 36.7 µM -0.317699838997783 0.438781384689531 no 1912 0.37535631667748 692 6080581
SGTC_2638 epoxomicin 18 µM -0.318976105026253 0.438466319840077 no 1913 0.374872316244149 682 9915668 A protesome inhibitor.
SGTC_3135 9127742 49.47 µM -0.320915429925778 0.437987643961526 no 1914 0.374137240254883 666 3643468
SGTC_372 0155-0182 15.9 µM -0.321317368657518 0.437888446344449 no 1915 0.373984947717658 679 771486
SGTC_946 3434-1334 87.4 µM -0.321853396674833 0.437756161853744 no 1916 0.373781880040661 676 4047976
SGTC_1448 4255-0083 152 µM -0.322066226403744 0.437703640273416 no 1917 0.373701261806338 726 5399660
SGTC_1027 k015-0025 8.67 µM -0.322480346411705 0.437601447935223 no 1918 0.373544412230411 672 3598955
SGTC_2921 7974240 10.71 µM -0.323777346131994 0.437281414451823 no 1919 0.37305330413997 719 2979074 YDR527W RBA50
SGTC_681 1642-0006 26.6 µM -0.324990545938475 0.436982095656854 no 1920 0.372594113456586 701 4446530
SGTC_3330 9141424 71.43 µM -0.325112067598748 0.436952116003914 no 1921 0.372548128017215 669 27261020
SGTC_1744 st037937 38.9 µM -0.325195266466095 0.436931590874566 no 1922 0.372516645488529 709 1016152
SGTC_1092 toremifene 6.32 µM -0.326181310304053 0.436688347173681 no 1923 0.372143590506381 732 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_232 clozapine 119 µM -0.326380493031009 0.436639214387395 no 1924 0.372068247245672 683 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_2106 5357045 167.29 µM -0.327555582729898 0.436349372669751 no 1925 0.371623855212851 690 668842
SGTC_1490 4089-0339 670 nM -0.328098219585668 0.436215540115486 no 1926 0.371418700059276 699 742542
SGTC_2141 5621638 7.665 µM -0.328119636314039 0.436210258177475 no 1927 0.371410603768331 717 2856238
SGTC_1323 1348-1351 11.2 µM -0.328209695169239 0.436188047379649 no 1928 0.371376558915851 698 6989654
SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM -0.328999439546312 0.435993285012999 no 1929 0.371078055826446 682 6857784
SGTC_554 4483-2211 187 µM -0.335026939983806 0.434507331006056 no 1930 0.368802382117304 682 747107
SGTC_2914 7968218 45.32 µM -0.336612460152855 0.434116606977699 no 1931 0.368204531001203 715 2977111
SGTC_797 k781-0471 270 µM -0.336866986913579 0.434053889243967 no 1932 0.368108586431637 667 23738129
SGTC_1100 amiodarone 5.07 µM -0.339284807938205 0.433458198917696 no 1933 0.367197593074547 673 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death.
SGTC_38 0929-0051 58.268 µM -0.33978573871379 0.43333480102066 no 1934 0.367008944238651 710 1379719
SGTC_3153 9100258 49.47 µM -0.340547055317429 0.433147272849106 no 1935 0.366722296473103 724 25236848
SGTC_1281 0884-0031 11.8 µM -0.341489428209462 0.432915167586285 no 1936 0.366367581079012 681 1548255
SGTC_575 k072-0246 11.9 µM -0.342428776987312 0.432683830189168 no 1937 0.366014117565144 694 6796779
SGTC_923 1900-2434 73.3 µM -0.344433234883904 0.432190261103673 no 1938 0.36526024916389 736 5910570
SGTC_405 ebelactone b 50 µM -0.34534647918928 0.43196542279597 no 1939 0.364916954087097 690 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).
SGTC_2757 clomiphene 4.22 µM -0.345841087235437 0.431843660810678 no 1940 0.364731072554497 714 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined.
SGTC_3067 9117431 49.47 µM -0.346238394229256 0.431745856964612 no 1941 0.364581781322417 709 17150885
SGTC_1233 0325-0408 14.2 µM -0.346463745370218 0.431690384823363 no 1942 0.364497112982128 710 12874
SGTC_1904 st060225 78 µM -0.352189159227699 0.430281479238386 no 1943 0.362348203235727 668 66595
SGTC_3053 9095903 49.47 µM -0.353099387942601 0.430057572101584 no 1944 0.362006965861331 734 17174018
SGTC_1035 k081-0041 55.2 µM -0.353561695168713 0.42994385776757 no 1945 0.361833692601513 723 731709
SGTC_1445 4239-0156 97.7 µM -0.355363067343357 0.429500827335353 no 1946 0.361158806774481 736 4008346
SGTC_2280 7785178 200 µM -0.355895082117353 0.429370000294377 no 1947 0.360959569450552 676 2954328
SGTC_2352 9027995 87.8 µM -0.358180270147823 0.428808141160201 no 1948 0.36010420561691 689 2997347
SGTC_113 0099-0221 2.5 µM -0.358764941487077 0.428664411157803 no 1949 0.359885470819354 677 89219
SGTC_3106 9121286 49.47 µM -0.358900260002495 0.428631147097434 no 1950 0.359834852557297 683 15943471
SGTC_2851 9015922 71.43 µM -0.362925014826433 0.427642012794884 no 1951 0.358330449906632 725 2996893
SGTC_12 0849-0099 9.267 µM -0.36356660115282 0.427484376706537 no 1952 0.358090835393204 715 6071388
SGTC_1540 guanosine 70.6 µM -0.364347538910119 0.427292517957664 no 1953 0.357799252445267 693 6802 Guanosine is a purine nucleoside
SGTC_3052 9092717 49.47 µM -0.364361682702181 0.427289043306164 no 1954 0.357793972265575 721 25237534
SGTC_2932 9016711 44.54 µM -0.364535103761413 0.427246440074029 no 1955 0.35772923269238 731 7117328
SGTC_1515 3460-0031 42.1 µM -0.364535330501066 0.427246384372917 no 1956 0.357729148051196 708 2876596
SGTC_812 4251-0442 148 µM -0.364622219395015 0.427225039258815 no 1957 0.357696713221163 719 5723007
SGTC_2794 7785382 27.27 µM -0.370462715545126 0.425790755321838 no 1958 0.35551887606256 741 2205081
SGTC_878 0828-0289 13.7 µM -0.370838967058979 0.425698390534406 no 1959 0.35537873797472 698 745350 YLR208W SEC13
SGTC_190 3970-0790 3.722 µM -0.371499394227746 0.425536274230777 no 1960 0.355132803528445 704 2832352
SGTC_1308 1187-1617 41.4 µM -0.372845102427425 0.425205979683806 no 1961 0.354631866196886 712 2882570
SGTC_2801 7907800 81.82 µM -0.376026233140956 0.424425402785881 no 1962 0.353448696792768 744 6620925
SGTC_1549 4'-methoxyflavonol 74.6 µM -0.376360994871717 0.424343277074166 no 1963 0.353324269733798 725 97141
SGTC_1965 Pectolinarigenin 58.4 µM -0.376363548290784 0.424342650667039 no 1964 0.353323320717723 703 5320438 An anti-inflammatory.
SGTC_2390 9097792 176.6 µM -0.378577023682487 0.423799710891862 no 1965 0.352500993395446 699 4497149
SGTC_422 cantharidin 155 µM -0.378596926600657 0.423794829591972 no 1966 0.352493602390001 690 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_2960 9079389 5.97 µM -0.387163497698306 0.421694926350023 no 1967 0.349317585770767 721 16457355
SGTC_2842 9000675 19.48 µM -0.387945952951209 0.421503234937033 no 1968 0.349028015254012 681 2989072
SGTC_1725 st036284 20.55 µM -0.390006580042778 0.42099849707534 no 1969 0.348265840643162 705 707914
SGTC_1804 st050076 49.1 µM -0.390517915613946 0.420873268661956 no 1970 0.348076805069791 712 3895976
SGTC_3000 9075062 71.4286 µM -0.390879392559742 0.420784746138955 no 1971 0.347943193479788 699 17057871
SGTC_3070 9117005 49.47 µM -0.391724799417528 0.420577729084559 no 1972 0.347630782121208 720 8779016
SGTC_1261 0712-0010 12.7 µM -0.392976281123875 0.420271315727167 no 1973 0.347168499965298 731 2840123
SGTC_2270 7924575 90.91 µM -0.393085766388065 0.420244511600192 no 1974 0.347128068240659 730 1262135
SGTC_2080 5212524 12.4 µM -0.393411065687825 0.420164874172808 no 1975 0.347007948992311 715 260183
SGTC_1629 st005085 44.9 µM -0.394338363429939 0.419937877778992 no 1976 0.346665621624844 735 24207091
SGTC_1851 st056236 18.9 µM -0.397479252405663 0.419169207106098 no 1977 0.345507041643494 723 5393171
SGTC_154 3389-1638 511.116 µM -0.399372157808864 0.41870610456833 no 1978 0.344809502942104 766 5238686
SGTC_803 4488-1585 147 µM -0.401166189570959 0.418267295588373 no 1979 0.344148885843837 728 747204
SGTC_320 4092-0846 5.34 µM -0.402214851764634 0.418010846421855 no 1980 0.343762956494193 706 1359356
SGTC_1280 0880-0253 10.1 µM -0.403325454031105 0.417739287886884 no 1981 0.343354409374687 740 6836607
SGTC_1762 st045503 25.4615 µM -0.403685944768143 0.417651151042453 no 1982 0.343221838248983 734 4645554
SGTC_1811 st050069 61.5 µM -0.403756263601125 0.417633959182451 no 1983 0.34319598061802 721 3877702
SGTC_2746 daunorubicin 9.88 µM -0.40375859519522 0.417633389146687 no 1984 0.343195123257154 717 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_567 1080-0542 68.4 µM -0.403831835101641 0.417615483302513 no 1985 0.343168192295359 696 5950415
SGTC_403 arphamenine a 50 µM -0.404870250428681 0.417361627767297 no 1986 0.342786443551961 750 5487158 An arginine aminopeptidase inhibitor.
SGTC_102 gallobenzophenone 83.616 µM -0.405490697619268 0.417209966973914 no 1987 0.342558427429658 726 70837
SGTC_1689 st020265 53.493 µM -0.407399143226627 0.416743547889809 no 1988 0.341857428068984 741 5758320 YPR016C TIF6
SGTC_660 4031-1742 102 µM -0.407982646011501 0.416600964704834 no 1989 0.341643207807149 701 6738706
SGTC_346 4513-0042 7.16 µM -0.409247768740553 0.416291860394365 no 1990 0.341178920929086 713 2827372
SGTC_2841 9004761 38.96 µM -0.411527731447126 0.415734933563779 no 1991 0.340342805564889 702 2991039
SGTC_1118 chelidonine 707.474 nM -0.412398802019547 0.415522201636123 no 1992 0.340023570544632 744 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor.
SGTC_1712 st032288 53.4 µM -0.412903955183263 0.415398845006336 no 1993 0.339838491582636 734 2883011
SGTC_2428 5615643 7.78 µM -0.415305605896297 0.414812484586253 no 1994 0.338959098966656 754 2253075
SGTC_1435 4092-0789 56.7 µM -0.415792086273306 0.414693733996799 no 1995 0.338781075103731 728 2248285
SGTC_1971 st069429 63.5 µM -0.415849227194422 0.414679786323663 no 1996 0.338760167172444 739 1246522 YGL099W LSG1
SGTC_1846 st056244 14.8 µM -0.415897884708864 0.41466790947169 no 1997 0.338742363721436 730 5393182
SGTC_2764 methyldopa 94.69 µM -0.417230205418005 0.414342732581318 no 1998 0.338255016817164 756 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent.
SGTC_2605 digitonin 300 nM -0.417858818816811 0.414189328516628 no 1999 0.338025171584066 737 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_1060 3448-7350 82 µM -0.41822627318818 0.414099662619852 no 2000 0.337890844086699 747 570178
SGTC_1670 st016595 4.04 µM -0.419436096420864 0.413804474268268 no 2001 0.337448724158937 740 597879
SGTC_1410 3909-8106 77.9 µM -0.420383583978765 0.413573327969822 no 2002 0.337102629227962 744 1039210
SGTC_1314 1222-0010 41.1 µM -0.421241996185643 0.413363938087319 no 2003 0.336789190420003 736 3526027
SGTC_1677 st019204 53.9 µM -0.422508930041434 0.413054943792035 no 2004 0.336326791985291 722 3945625
SGTC_3203 9113543 49.47 µM -0.422998668693014 0.41293551515957 no 2005 0.336148116191484 708 17018012
SGTC_2749 bexarotene 57.39 µM -0.424166891970533 0.412650662484493 no 2006 0.335722052203461 722 82146 An retinoic acid receptor inhibitor.
SGTC_2413 inermin 26.06 µM -0.428539953517824 0.411584770458815 no 2007 0.334129025902707 752 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1
SGTC_2158 5657123 3.6195 µM -0.431911490292595 0.410763435329403 no 2008 0.332902871644928 781 2858827
SGTC_482 fipronil 114 µM -0.432379014224226 0.410649573307264 no 2009 0.332732984011624 710 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels.
SGTC_218 alverine citrate 93.75 µM -0.433594366386729 0.410353618458759 no 2010 0.332291513229475 739 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_623 k072-0108 16.9 µM -0.434800104027821 0.410060055317277 no 2011 0.331853764702123 736 5382803
SGTC_2216 7189485 200 µM -0.434888399272247 0.41003855989169 no 2012 0.331821717722029 728 731273
SGTC_2959 9079155 11 µM -0.435635777191747 0.40985662200904 no 2013 0.331550504345391 773 16189457
SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM -0.436906796163285 0.409547256194433 no 2014 0.331089471498408 698 6708514
SGTC_1489 4065-0444 182 µM -0.437744581385558 0.409343370185346 no 2015 0.330785724129149 739 2877968
SGTC_1929 genistein trimethyl ether 50.5 µM -0.439671460756679 0.408874531982568 no 2016 0.330087537778504 706 136420
SGTC_2385 9074692 200 µM -0.440239179815515 0.408736422383797 no 2017 0.329881942864554 723 17046906
SGTC_2036 5160441 105 µM -0.440619936230925 0.40864380172693 no 2018 0.329744083756821 737 134534 YIL048W NEO1
SGTC_1681 tripelennamine 100 µM -0.441949705632605 0.408320369584162 no 2019 0.329262800453526 698 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist.
SGTC_2461 5755302 26.15 µM -0.442076399620693 0.408289557790815 no 2020 0.329216960854132 767 2788904
SGTC_582 0987-0078 156 µM -0.443950096007572 0.407833943857588 no 2021 0.328539332209149 753 1625765
SGTC_2967 9089538 49.85 µM -0.444252514658157 0.407760418446579 no 2022 0.328430014238591 767 728216
SGTC_1996 st072960 66.8 µM -0.444344785335401 0.407737985822516 no 2023 0.328396663256408 697 1719405
SGTC_1322 1348-1070 12 µM -0.444457339562467 0.407710622320386 no 2024 0.328355982692298 744 6758089
SGTC_1973 st070275 50.2 µM -0.445058802643495 0.407564405892587 no 2025 0.328138629914174 741 17118334
SGTC_2031 5180455 200 µM -0.446112520124051 0.407308276905138 no 2026 0.327757984683952 743 29949
SGTC_2564 betulinic acid 100 µM -0.447498771378783 0.406971378713214 no 2027 0.327257487384038 770 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14
SGTC_266 formosanin C 406 nM -0.450894192752263 0.406146486675559 no 2028 0.32603290458618 731 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1
SGTC_552 k242-0005 476 µM -0.451982433521941 0.405882194728621 no 2029 0.325640818724455 773 4088318
SGTC_2779 methotrexate 400 µM -0.454497299217333 0.405271594578414 no 2030 0.324735467692736 733 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2
SGTC_1782 st039423 80.636 µM -0.456390339521082 0.404812123313554 no 2031 0.324054655658255 758 2068169
SGTC_2583 asiatic acid 100 µM -0.456451185499888 0.404797357190992 no 2032 0.324032782784144 765 5320556 A kinase inhibitor; arrests cells at G2/M.
SGTC_1855 st056195 39.6 µM -0.457570800642745 0.404525672831075 no 2033 0.323630412735439 711 4028379
SGTC_1742 st038235 28.8875 µM -0.458481437732367 0.404304732751268 no 2034 0.323303297690109 766 564103 YBR002C RER2
SGTC_2360 9040895 200 µM -0.462450820140528 0.403342032781996 no 2035 0.321879031197102 735 4914414
SGTC_1268 0828-0275 2.46 µM -0.46245656721744 0.4033406393583 no 2036 0.321876970959906 741 745337
SGTC_2177 5811945 192 µM -0.463249563074095 0.403148383092033 no 2037 0.3215927468737 750 5343475
SGTC_3072 9116419 49.47 µM -0.463883274853591 0.402994760955792 no 2038 0.321365688125677 743 17170162
SGTC_1817 st052116 64.4 µM -0.464140826948883 0.402932330378524 no 2039 0.32127342635369 739 4361398
SGTC_2859 9028643 45.46 µM -0.464951751046116 0.402735778705603 no 2040 0.320983004574846 738 17151580
SGTC_3253 9135987 49.47 µM -0.465727024132545 0.402547891101629 no 2041 0.320705453099917 749 4182430
SGTC_622 1348-1566 26.3 µM -0.46576257290768 0.402539276387477 no 2042 0.3206927288698 738 7340407
SGTC_1321 1326-2144 215 µM -0.465995815361563 0.40248275474019 no 2043 0.320609247938308 758 3513030
SGTC_1619 st003326 88.7 µM -0.467452530918977 0.402129795005333 no 2044 0.320088073274376 705 2849032
SGTC_993 3909-8757 62.7 µM -0.469931623461775 0.401529298631535 no 2045 0.319201935006132 735 4288324 YLR208W SEC13
SGTC_1863 st057641 20.1 µM -0.470216017151749 0.401460426415308 no 2046 0.319100345903033 753 3921635
SGTC_1779 st039427 55 µM -0.470270565714016 0.401447216625416 no 2047 0.319080862003768 779 1124498
SGTC_905 2-aminofluorene 215 µM -0.470841430182976 0.401308979600658 no 2048 0.31887698807496 725 1539 An established DNA mutagen. YPR165W RHO1
SGTC_764 1951-2361 146 µM -0.472063123889102 0.401013183299259 no 2049 0.318440866410072 746 5438930
SGTC_1912 st060209 90.8 µM -0.472749792643874 0.400846952055879 no 2050 0.318195848935039 784 688787
SGTC_149 3970-0822 46.1 µM -0.473715510358848 0.400613198019614 no 2051 0.317851395664691 737 3114250 YBL034C STU1
SGTC_2943 9068529 45.32 µM -0.47395669171866 0.400554825106669 no 2052 0.317765395404613 752 3270634
SGTC_1704 st028805 70.8 µM -0.474309903340917 0.400469341615809 no 2053 0.317639465222314 757 2876101
SGTC_3113 9123498 49.47 µM -0.476899074609741 0.399842861952614 no 2054 0.316716995489193 760 8897275
SGTC_3347 9188721 44.724 µM -0.480941073938899 0.398865369640457 no 2055 0.315279189725232 766 44118411 YKL104C | YBL026W GFA1 | LSM2
SGTC_548 1436-0017 110 µM -0.481711841968435 0.398679043615552 no 2056 0.31500533128623 766 9677137
SGTC_3295 9122362 53.5725 µM -0.482083379587059 0.398589236086473 no 2057 0.314873358078636 770 4730473
SGTC_1739 st037196 92.5 µM -0.483811754223765 0.398171526567245 no 2058 0.314259736188294 759 612214
SGTC_106 0092-0003 11.579 µM -0.483948708007237 0.39813843288123 no 2059 0.314211135633364 752 1072148
SGTC_980 1473-0395 201 µM -0.485769667426901 0.397698483665597 no 2060 0.313565241286931 762 768876
SGTC_1841 st054148 70 µM -0.491911786402318 0.396215491848739 no 2061 0.31139085287517 771 675442
SGTC_1246 0422-0085 105 µM -0.492271268568827 0.396128742490129 no 2062 0.311263794199037 779 264295
SGTC_3314 9135860 59.4275 µM -0.492787564226982 0.39600416028178 no 2063 0.311081349259253 771 25252478
SGTC_1604 st002052 72.4 µM -0.49379300048945 0.395761578876282 no 2064 0.310726188474442 737 6254834 YHR062C RPP1
SGTC_1423 4048-0112 5.59 µM -0.494615716402864 0.395563112400458 no 2065 0.310435703042032 753 X1423
SGTC_3026 9090633 49.47 µM -0.495278580921152 0.395403227100232 no 2066 0.310201744077245 756 25236842
SGTC_2606 farnesol 9.78 µM -0.498932775002702 0.394522139088657 no 2067 0.308913371837762 775 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_1832 st054113 55 µM -0.500714657333152 0.394092692448139 no 2068 0.308285977627554 762 1251267
SGTC_285 1486-1325 46 µM -0.500990636418558 0.394026190975351 no 2069 0.308188856410099 750 22310230
SGTC_2283 7944793 200 µM -0.501099668674509 0.39399991880102 no 2070 0.30815049000887 744 2970533
SGTC_1987 st072290 61.9 µM -0.5022591185462 0.393720570152624 no 2071 0.307742631125306 766 54697379
SGTC_1997 st073024 93.8 µM -0.503858890099169 0.393335223700411 no 2072 0.307180270500716 759 686268
SGTC_3055 9094636 49.47 µM -0.503911683682635 0.393322508775779 no 2073 0.307161719922976 747 25236176
SGTC_2152 5568786 200 µM -0.503951935469479 0.393312814521919 no 2074 0.307147576605789 766 5399883
SGTC_2425 5628681 7.85 µM -0.505956328101337 0.392830159702893 no 2075 0.30644365403068 776 5714958
SGTC_2416 tofa 880 nM -0.507290630786062 0.392508952848273 no 2076 0.305975455771227 763 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_2769 toremifene 3.73 µM -0.510700143586949 0.391688513410844 no 2077 0.304780520086913 744 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_114 0364-0001 490.298 µM -0.510812588410391 0.391661463718709 no 2078 0.304741146780805 759 4003655
SGTC_453 enantio-paf c16 10 µM -0.510820199987801 0.391659632698915 no 2079 0.304738481617845 784 13871343 A lipid and platelet activating factor
SGTC_161 4065-0411 162.148 µM -0.513509486475128 0.391012855964474 no 2080 0.303797488315242 773 1906281 YLR208W SEC13
SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM -0.513742679550483 0.390956786912263 no 2081 0.303715954132817 737 6708561
SGTC_2439 5492030 7.2 µM -0.514054679061599 0.39088177314888 no 2082 0.303606881157299 754 5722370
SGTC_2419 paclitaxel 166.5 µM -0.518654636462063 0.389776282100848 no 2083 0.302000800564469 777 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_811 0416-0114 265 µM -0.518763531983072 0.389750122398481 no 2084 0.301962825839384 770 6612453
SGTC_1179 1021-1431 9.29 µM -0.519450993663803 0.389584986708328 no 2085 0.301723139447562 788 2840958
SGTC_2620 irigenin 100 µM -0.5205628596051 0.389317946751921 no 2086 0.301335663902031 770 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro.
SGTC_3118 9124250 49.47 µM -0.520640672094531 0.389299260263734 no 2087 0.301308555321077 775 1504786
SGTC_2268 7933382 153.85 µM -0.520647532617234 0.389297612737458 no 2088 0.301306165281415 743 935025 YOR257W CDC31
SGTC_3093 9117344 49.47 µM -0.521925869399575 0.388990660185306 no 2089 0.300860972845894 737 24824913
SGTC_1178 0988-0033 191 µM -0.521948311609072 0.388985272009611 no 2090 0.30085315979254 751 5392207
SGTC_1031 k035-0009 16 µM -0.522504593503493 0.388851720481031 no 2091 0.300659524511762 786 5180959
SGTC_2327 6189656 200 µM -0.522581072743239 0.388833360458186 no 2092 0.300632907373909 786 5349088
SGTC_2836 9010338 19.48 µM -0.522644436820871 0.388818149120658 no 2093 0.300610855523372 737 2994051
SGTC_2803 7707263 71.43 µM -0.522771988840479 0.388787529183621 no 2094 0.300566467317229 756 2199229
SGTC_3281 9140613 49.47 µM -0.524711441761846 0.388322032391064 no 2095 0.299891901079271 741 16013766
SGTC_2531 methyl deoxycholate 70.07 µM -0.525872349031104 0.388043474513832 no 2096 0.299488451006156 788 16667744 Haematoxylin.
SGTC_1819 st053448 58.6 µM -0.528027247837106 0.387526562699006 no 2097 0.298740212095936 795 2857616
SGTC_2829 7992743 58.44 µM -0.530711844348129 0.386882867209816 no 2098 0.297809238502784 769 16462845
SGTC_438 sphingosine 6.67 µM -0.532542414072097 0.386444123063393 no 2099 0.297175186999669 757 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes.
SGTC_3242 9133940 49.47 µM -0.535195856442193 0.385808413646858 no 2100 0.29625721561951 789 17248444
SGTC_2138 5575593 77.673 µM -0.53533753507068 0.385774479010522 no 2101 0.296208237798584 789 762213
SGTC_1380 2291-0730 164 µM -0.536436300043635 0.385511334295044 no 2102 0.295828524643397 767 2999191
SGTC_1398 3558-0053 112 µM -0.536635220797296 0.385463700123349 no 2103 0.295759805165706 753 4532369
SGTC_44 0929-0055 61.211 µM -0.536907914335496 0.385398402902853 no 2104 0.295665611946065 735 1379590
SGTC_2603 homopterocarpin 100 µM -0.537924570167784 0.385154990502664 no 2105 0.295314562441714 774 101795 A weak amylase inhibitor.
SGTC_24 0417-1663 219 µM -0.539604432654957 0.384752889306173 no 2106 0.29473492952235 794 4329390
SGTC_3085 9117376 49.47 µM -0.543415579218436 0.383841092293321 no 2107 0.293421850766725 758 16480349
SGTC_2217 6934799 96.0675 µM -0.544271145929985 0.383636490558124 no 2108 0.2931274497873 765 675606
SGTC_2145 5634607 200 µM -0.549664574013846 0.38234744561569 no 2109 0.291274729678431 788 308662
SGTC_29 0299-0004 12.984 µM -0.550516100220489 0.382144047096231 no 2110 0.290982718514876 781 16871 A napthoquinone isolated from Swertia calycina.
SGTC_2304 7443016 91.4 µM -0.551242678646153 0.381970519749904 no 2111 0.290733663496898 791 939854
SGTC_2526 patulin 37.61 µM -0.551331737968337 0.381949251511544 no 2112 0.290703142790162 776 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.
SGTC_616 4092-0450 108 µM -0.551876333347769 0.38181920455395 no 2113 0.290516542088624 791 787165
SGTC_1460 k062-0059 9.15 µM -0.552446314723005 0.381683109816454 no 2114 0.290321303160926 746 1373085
SGTC_860 0443-0016 25.1 µM -0.55355115637218 0.381419347885365 no 2115 0.289943030624941 781 5337942
SGTC_3300 9124615 50.48 µM -0.554245443335153 0.381253626985591 no 2116 0.289705440944053 790 24824903
SGTC_309 k408-0051 1.48 µM -0.555985184284917 0.38083846004174 no 2117 0.289110491534832 790 3640463
SGTC_1968 st069590 43.6 µM -0.556740802377938 0.380658184135593 no 2118 0.288852267479191 781 6384066
SGTC_670 4204-0025 119 µM -0.558723123762682 0.380185363719496 no 2119 0.288175347723815 775 719039
SGTC_1130 3454-2858 15.9 µM -0.56244780568003 0.379297442616218 no 2120 0.28690547777129 818 715628 YIL048W NEO1
SGTC_1370 2001-0092 44.6 µM -0.570168239872482 0.377459011582878 no 2121 0.284281797550954 799 790957
SGTC_2173 5763948 167 µM -0.570229325981561 0.37744447643624 no 2122 0.284261084113673 772 2867177
SGTC_2729 fluphenazine 10.66 µM -0.571435056429446 0.37715761421226 no 2123 0.283852385673588 799 3372 An atypical antipsychotic.
SGTC_1521 st012942 49.4 µM -0.573811257492398 0.376592477177457 no 2124 0.283047764988206 772 24207259
SGTC_2621 lithochol-11-enic acid 100 µM -0.57471530359549 0.376377535301117 no 2125 0.282741927876857 813 6708711
SGTC_1685 st024049 53.0905 µM -0.574827578999754 0.376350843887693 no 2126 0.282703956403328 789 1941139
SGTC_2306 7482397 179.52 µM -0.577078310389464 0.375815898769069 no 2127 0.281943277800792 809 891448
SGTC_2443 5493264 126.67 µM -0.579054908911799 0.375346305213619 no 2128 0.281276061965863 800 5340055
SGTC_2627 acetyl isogambogic acid 100 µM -0.579186821611138 0.375314972408461 no 2129 0.281231560981334 795 6857789 A caspase activator and apoptosis inducer.
SGTC_2008 4012253 172 µM -0.58029159931196 0.375052590376133 no 2130 0.280858995774298 779 603940
SGTC_470 aa-861 153 µM -0.581142091561159 0.374850639899775 no 2131 0.280572346130104 766 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor.
SGTC_3341 9147222 25.867 µM -0.582575415468531 0.374510372963311 no 2132 0.280089579657869 802 1939759
SGTC_481 bay k-8644 50 µM -0.584219864725846 0.374120105840585 no 2133 0.279536199175368 816 2303 A calcium channel antagonist.
SGTC_1948 st076329 66.6 µM -0.585343315508144 0.3738535582414 no 2134 0.279158447528316 796 24208413
SGTC_1613 st002381 52.1 µM -0.586241926590312 0.373640399051793 no 2135 0.278856475232783 792 551167
SGTC_2097 5376186 200 µM -0.586531847248808 0.37357163532686 no 2136 0.27875908324288 769 742755
SGTC_976 1348-1067 47.6 µM -0.586990993937134 0.373462742607343 no 2137 0.278604877651645 790 5310671 YGL099W LSG1
SGTC_2120 5538279 151.968 µM -0.587101691845101 0.37343649064326 no 2138 0.278567705692024 777 2058197
SGTC_1922 5578187 25 µM -0.587259954270467 0.373398959793313 no 2139 0.278514565934259 771 1350412
SGTC_1375 2910-0797 186 µM -0.587272187149556 0.373396058899838 no 2140 0.278510458707353 811 742508
SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM -0.587508215671009 0.373340088722556 no 2141 0.27843121718035 789 2724278 An inhibitor of dopamine biosynthesis.
SGTC_394 menadione 8.33 µM -0.590539567423523 0.37262149278417 no 2142 0.277414483426336 801 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_1820 st053765 18.6 µM -0.591393489825423 0.372419146421983 no 2143 0.277128400690987 785 3690829
SGTC_2288 7946289 167.31 µM -0.596510186664357 0.371207427914159 no 2144 0.275417225381519 806 1246052
SGTC_742 0kpi-0133 140 µM -0.598220232916251 0.370802744452606 no 2145 0.274846496382958 794 2728852
SGTC_2047 4141938 200 µM -0.59963152003562 0.3704688701064 no 2146 0.274375917911419 797 3807862
SGTC_21 0849-0113 22.993 µM -0.600185877869277 0.370337749926085 no 2147 0.274191182125057 787 1560156
SGTC_936 3005-4620 401 µM -0.600200183117926 0.370334366558565 no 2148 0.274186415816403 805 777207
SGTC_228 caffeine 993.056 µM -0.601300533465121 0.370074150226941 no 2149 0.273819917164292 777 2519 Caffeine is a phosphodiesterase inhibitor.
SGTC_1791 st048313 56.1 µM -0.601447008458567 0.370039515572886 no 2150 0.27377114835373 784 1204976
SGTC_463 ikarugamyin 104 µM -0.602127280310312 0.369878676130235 no 2151 0.273544708339688 815 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis.
SGTC_2086 5274770 176.623 µM -0.602943008624822 0.369685840174034 no 2152 0.273273301621588 786 689278
SGTC_168 3970-0862 530.542 µM -0.604191202923548 0.36939083388289 no 2153 0.272858264475515 810 3135186
SGTC_583 1488-1091 88.9 µM -0.606339548167159 0.368883260248673 no 2154 0.272144651026235 816 4303273
SGTC_321 4534-3890 65.3 µM -0.608852085013218 0.368289931804872 no 2155 0.271311243141345 802 699746
SGTC_1160 4092-0570 10.5 µM -0.616679258527534 0.366443585294507 no 2156 0.268723152365736 812 4994975
SGTC_1496 4469-0713 57.4 µM -0.616772261061818 0.366421665466031 no 2157 0.268692475375241 815 746691
SGTC_1025 k007-0731 70 µM -0.617382787360398 0.366277780943954 no 2158 0.268491136287274 804 6256118
SGTC_2393 9031399 185.94 µM -0.617757241538156 0.36618954152937 no 2159 0.268367686493966 820 1526623 YDL150W RPC53
SGTC_2676 harmalol 100 µM -0.618471080196942 0.36602134641174 no 2160 0.268132427769324 795 5459187 A monoamine oxidase inhibitor
SGTC_888 0916-0002 6.97 µM -0.619877929990954 0.365689938960451 no 2161 0.267669078478602 787 2802138 YIL048W NEO1
SGTC_867 0518-0118 155 µM -0.620715682577687 0.365492639649488 no 2162 0.267393354524426 808 6848158
SGTC_421 streptovitacin 30 mM -0.621626655649651 0.365278136551412 no 2163 0.267093694681948 811 91467 include heat shock
SGTC_787 4152-0075 138 µM -0.625840723996954 0.364286416417762 no 2164 0.265709708751651 799 9566539
SGTC_289 k017-0060 526 µM -0.626473239470364 0.364137641239147 no 2165 0.265502292042384 811 5512909
SGTC_1443 4112-3303 14 µM -0.626637333731692 0.364099047656574 no 2166 0.265448495094788 823 704433
SGTC_2122 5258151 111.688 µM -0.62673998713382 0.364074905145239 no 2167 0.265414843837675 802 2173356
SGTC_2896 9052656 71.43 µM -0.628618680258383 0.363633160599793 no 2168 0.264799363886237 815 6469436
SGTC_1864 st057645 30.4 µM -0.629222557554834 0.363491207003124 no 2169 0.26460168144503 817 688666
SGTC_784 4579-0127 173 µM -0.629390687116183 0.363451688076973 no 2170 0.264546656703267 820 1948547
SGTC_3354 9151612 71.43 µM -0.630302248166915 0.363237450564512 no 2171 0.264248426187685 800 27261949
SGTC_2736 butenafine 14.65 µM -0.633875927399317 0.362397968084174 no 2172 0.263080898410588 814 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_387 norethindrone acetate 66.7 µM -0.63420005503509 0.36232186086102 no 2173 0.262975135832476 823 541197
SGTC_276 colchicine 750 µM -0.634727897662212 0.362197931714234 no 2174 0.262802947751091 824 2833 A microtubule depolymerizer.
SGTC_166 k072-0058 166.424 µM -0.635906324739041 0.361921307703884 no 2175 0.262418740025302 813 5846229
SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM -0.636056129895744 0.361886147600423 no 2176 0.26236991900813 850 6728940
SGTC_1069 diphenylcyclopropenone 8.49 µM -0.638769203276966 0.361249576186736 no 2177 0.261486542778272 842 65057 A dermal irritant. YDR527W RBA50
SGTC_3297 9117502 71.43 µM -0.641595399617284 0.360586870936479 no 2178 0.260567960372799 798 7453720
SGTC_1710 st031758 61.5 µM -0.64184219324851 0.360529020969891 no 2179 0.260487825394251 812 5394341
SGTC_2161 5662504 8.5105 µM -0.642659615602235 0.360337434873816 no 2180 0.260222495414908 805 2859334
SGTC_3326 9140064 16.379 µM -0.642687676870922 0.360330858542427 no 2181 0.260213389382954 828 1868434
SGTC_3057 9095946 49.47 µM -0.64481781842238 0.359831767487105 no 2182 0.259522626738792 828 24540043
SGTC_2704 st078022 71.1 µM -0.646246940700116 0.359497058734514 no 2183 0.259059722070143 826 54697681
SGTC_1344 1488-0097 29.1 µM -0.647061886467634 0.359306241924685 no 2184 0.258795945596569 836 747966
SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM -0.65193498919891 0.358165954955585 no 2185 0.257221556015259 812 4174840
SGTC_1919 st067113 52.3 µM -0.652663543116699 0.357995584555209 no 2186 0.256986605264079 833 1268243
SGTC_2376 9072922 81.32 µM -0.6561370649333 0.357183700019477 no 2187 0.255867969010784 821 17087968
SGTC_1792 st045773 43.6 µM -0.656423728081734 0.357116725548467 no 2188 0.25577576373841 770 2919270
SGTC_950 1165-0508 94.1 µM -0.65665883131153 0.357061800551561 no 2189 0.25570015567526 821 6148369
SGTC_2777 climbazole 1.536 µM -0.657072222951859 0.356965230863478 no 2190 0.255567239226278 819 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2
SGTC_323 4013-0906 34.3 µM -0.660538499588036 0.356155858005137 no 2191 0.25445416035464 794 2910086
SGTC_1502 4534-4282 27.7 µM -0.662634877076218 0.355666669572485 no 2192 0.253782213656397 835 3278949
SGTC_2191 5911152 200 µM -0.663593273076293 0.355443107536796 no 2193 0.253475331947321 814 2875902
SGTC_375 3970-0961 9.27 µM -0.664156552141079 0.355311736390031 no 2194 0.253295059069738 811 2898222
SGTC_1768 st044301 37.178 µM -0.665587591015101 0.354978058717801 no 2195 0.252837370063301 854 3931349
SGTC_755 1995-0008 37.3 µM -0.666917196886592 0.354668131990175 no 2196 0.252412512851736 792 689533
SGTC_2784 7567673 72.73 µM -0.667634464314772 0.354500979250164 no 2197 0.252183476280384 818 3471247
SGTC_2972 9093619 59.92 µM -0.667659487112231 0.354495148417269 no 2198 0.252175488023831 792 25236256
SGTC_3226 9131256 49.47 µM -0.667701860360613 0.354485274645758 no 2199 0.252161961128444 795 17178073
SGTC_2593 nobiletin 86.24 µM -0.674568501349237 0.35288651306192 no 2200 0.249974975393101 817 72344 An anti-infammatory.
SGTC_3048 9093155 49.47 µM -0.675798793591009 0.352600337060602 no 2201 0.249584200384554 801 25236002
SGTC_831 k061-1017 217 µM -0.677697310456989 0.352158890262505 no 2202 0.248981816041071 836 1240153
SGTC_270 tamoxifen 5.46 µM -0.679194183476826 0.351810974832912 no 2203 0.248507416130889 844 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen. YIL048W NEO1
SGTC_6 0844-0013 19.835 µM -0.680371399006979 0.351537443931045 no 2204 0.248134663011265 850 1584900
SGTC_1646 st011709 75.6 µM -0.681825863522771 0.351199599225547 no 2205 0.247674534037346 830 5757843
SGTC_1254 0550-0035 264 µM -0.682054525494367 0.351146496044512 no 2206 0.247602236862161 830 15121435
SGTC_1837 st055472 66.5 µM -0.682936414479097 0.350941718293268 no 2207 0.247323511314749 818 676091
SGTC_315 k915-0449 187 µM -0.684169191603266 0.350655535626173 no 2208 0.246934167053101 825 20970215 YNL149C PGA2
SGTC_975 1335-0046 28.5 µM -0.685962667377256 0.350239341075155 no 2209 0.24636832526036 842 16486740
SGTC_2552 juarezic acid 87.02 µM -0.686694074721769 0.350069662037888 no 2210 0.246137765824382 822 1549512
SGTC_720 r052-1644 49.9 µM -0.688198432340534 0.34972076054561 no 2211 0.245663915502127 827 1422863 YOR257W CDC31
SGTC_1487 3970-0795 2.82 µM -0.688724996556418 0.349598665930195 no 2212 0.245498171409824 828 3765103
SGTC_3185 9108267 49.47 µM -0.693528480374514 0.348485600191733 no 2213 0.243988979527357 834 4910486
SGTC_1107 amlodipine 47 µM -0.694381810035285 0.348288002263116 no 2214 0.243721399008986 801 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.
SGTC_220 paclitaxel 373.376 µM -0.694831149368114 0.348183969311278 no 2215 0.243580562355017 816 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_55 0767-0285 6.563 µM -0.695125167227673 0.348115903229012 no 2216 0.243488431983377 850 3116166
SGTC_1862 st057513 3.81 µM -0.695224427532634 0.348092925253034 no 2217 0.243457333059716 845 5393163
SGTC_504 lovastatin 124 µM -0.695261853051342 0.348084261686068 no 2218 0.243445607949143 847 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1
SGTC_328 k915-0120 63.5 µM -0.698227738099004 0.347397946664844 no 2219 0.242517391091416 816 6624543
SGTC_2042 p-Dimethylaminoacetophenone 200 µM -0.69863795612308 0.347303060250203 no 2220 0.242389158462653 839 75037 A free radical scavenger.
SGTC_2136 5328288 199.296 µM -0.699860504811634 0.347020332618389 no 2221 0.242007212270896 833 262395
SGTC_879 0831-1030 162 µM -0.699869356334629 0.347018285918041 no 2222 0.242004448086713 835 1549252
SGTC_1045 1348-1485 165 µM -0.700754513906638 0.346813637210879 no 2223 0.241728114516538 828 6810614
SGTC_305 1682-2595 20.8 µM -0.704001747078361 0.346063258924431 no 2224 0.240715842802391 838 226033
SGTC_955 1216-0110 33 µM -0.70604816930106 0.34559067693902 no 2225 0.240079091236291 845 3619719
SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM -0.706733246550356 0.345432525185399 no 2226 0.239866132345634 844 5024745
SGTC_689 0833-0039 98 µM -0.707733746438267 0.345201605825974 no 2227 0.239555308332247 877 5374726
SGTC_1224 0823-0416 294 µM -0.709373549075671 0.344823257490471 no 2228 0.239046348832219 835 3598164
SGTC_2486 5283202 22.39 µM -0.709769962942121 0.344731816992647 no 2229 0.238923399270017 833 1377751
SGTC_909 3448-9333 149 µM -0.710163849474568 0.344640968456448 no 2230 0.238801267830394 850 3344074
SGTC_1935 st074532 41.6 µM -0.711453457271483 0.344343587687658 no 2231 0.238401641323003 842 2829742
SGTC_3216 9129716 49.47 µM -0.711520818998413 0.344328056861447 no 2232 0.238380777191267 821 8056934
SGTC_2420 aureobasidin a 50 nM -0.711770143640339 0.344270575202295 no 2233 0.238303561889247 822 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1
SGTC_693 4161-2696 114 µM -0.711845892466422 0.344253112064505 no 2234 0.238280105355365 858 805759
SGTC_719 2810-4230 27.3 µM -0.712474807390016 0.34410813481697 no 2235 0.238085403144489 835 721079
SGTC_2011 4012611 177 µM -0.713511729130824 0.343869154015951 no 2236 0.237764578888862 834 2049887
SGTC_817 1391-0715 46 µM -0.71352368838205 0.343866398114243 no 2237 0.237760880072573 854 1353946
SGTC_15 0266-0086 27.098 µM -0.714377254855536 0.343669722843228 no 2238 0.237496966351251 860 1712902 YIL048W NEO1
SGTC_109 0132-0036 33.701 µM -0.716700743692914 0.343134568572187 no 2239 0.236779383458041 815 67274 A color developer.
SGTC_607 4491-0986 66.8 µM -0.719894277212475 0.342399535766696 no 2240 0.235795045911363 824 698981 YDR232W HEM1
SGTC_2435 5706476 10.6 µM -0.72091775517921 0.342164095241564 no 2241 0.235480059055917 815 5725375
SGTC_1499 4480-0877 67.3 µM -0.722312798409674 0.3418432787744 no 2242 0.235051092993405 829 2861909
SGTC_370 0180-0345 38.7 µM -0.723166292180266 0.341647058085622 no 2243 0.234788862602835 827 3989527
SGTC_516 3992-2719 87.3 µM -0.727061618238534 0.340752055247543 no 2244 0.233594104870011 847 5350887 YDR037W KRS1
SGTC_2307 7538926 6.34 µM -0.729920928918556 0.340095660398083 no 2245 0.232719259288178 856 96582
SGTC_501 nsc-95397 161 µM -0.732057317767826 0.339605538396706 no 2246 0.232066791965296 849 262093
SGTC_2487 5918373 44.05 µM -0.73315239347971 0.339354415440741 no 2247 0.231732743766768 843 2876279
SGTC_1439 4092-1168 46 µM -0.735453171232034 0.338827033145316 no 2248 0.231031774828807 858 2886240
SGTC_859 0439-0102 54.6 µM -0.736398847894977 0.338610357465707 no 2249 0.230744002794073 848 610143
SGTC_365 0121-0052 13.6 µM -0.737766114728899 0.338297180489572 no 2250 0.230328293936562 814 3101739
SGTC_1191 1487-1166 10.6 µM -0.74334835534082 0.337019712208921 no 2251 0.228635401426303 874 3955771
SGTC_3248 9135562 49.47 µM -0.745835456158282 0.33645115507981 no 2252 0.227883409355566 849 17650701
SGTC_2264 7948757 110.76 µM -0.747289866593758 0.336118846511679 no 2253 0.227444303978737 838 2971411
SGTC_748 act1.228 77.9 µM -0.747391057722596 0.336095730784559 no 2254 0.227413770807421 838 4421505 YNR035C ARC35
SGTC_3117 9124945 49.47 µM -0.748163518057891 0.335919293233674 no 2255 0.227180766560332 838 17592065
SGTC_1177 0983-0204 23.6 µM -0.748832995094798 0.335766407325353 no 2256 0.226978934997093 842 766818
SGTC_48 0382-0018 55 µM -0.750153367470854 0.335464958617347 no 2257 0.226581170346809 839 762596
SGTC_2497 7-hydroxyflavone 100 µM -0.751128991227981 0.335242286041013 no 2258 0.226287514827667 875 5281894
SGTC_3348 9149464 3.537 µM -0.752109297968609 0.335018602932966 no 2259 0.225992666434302 844 1951442
SGTC_876 0720-0963 56.8 µM -0.752509785369294 0.334927237887761 no 2260 0.225872273728536 867 765861
SGTC_172 1112-0046 2.638 µM -0.752970869456176 0.334822060737928 no 2261 0.225733709648536 864 2802135 YIL048W NEO1
SGTC_696 1560-0013 611 µM -0.753159784310101 0.334778971415427 no 2262 0.225676951219301 844 1650269
SGTC_2791 5663188 71.43 µM -0.753649814630937 0.334667211231896 no 2263 0.225529761945567 851 54690634
SGTC_941 3237-0776 460 µM -0.754519610608224 0.334468874768517 no 2264 0.225268637198415 857 760008
SGTC_810 3825-7150 143 µM -0.759111837385378 0.333422492562895 no 2265 0.223892829309135 814 22330411 YGL099W LSG1
SGTC_3174 9107204 49.47 µM -0.759145637363518 0.333414795709569 no 2266 0.223882720740918 869 3938802
SGTC_2206 7254556 146.969 µM -0.759371412517925 0.33336338450945 no 2267 0.223815204760008 848 4398905
SGTC_2457 5731572 11.68 µM -0.759860716625062 0.33325197594585 no 2268 0.223668922598166 854 2865357
SGTC_1047 2043-3044 82 µM -0.761071452572648 0.332976369422909 no 2269 0.223307195236692 885 669592
SGTC_3349 9149703 23.001 µM -0.761464931755746 0.332886818992801 no 2270 0.223189708552818 844 4910494
SGTC_2832 7992762 51.95 µM -0.763649866037325 0.332389731636547 no 2271 0.222537962158663 857 2985177
SGTC_3137 9097352 49.47 µM -0.765901642181842 0.331877745604648 no 2272 0.22186741436326 873 44120435
SGTC_300 r073-0011 5.04 µM -0.767735444582501 0.331461025975809 no 2273 0.221322186952782 855 2735780
SGTC_2384 9036245 200 µM -0.768275531321882 0.331338334522234 no 2274 0.221161754178631 830 6462766
SGTC_1056 3448-1962 115 µM -0.771326543701568 0.330645576593382 no 2275 0.220256701425826 872 715507
SGTC_1485 3909-9022 254 µM -0.772553840321105 0.330367071982305 no 2276 0.219893235784532 875 714516
SGTC_822 1487-0950 154 µM -0.772659728495477 0.330343047679956 no 2277 0.219861892989301 847 1958375
SGTC_756 0508-1999 28.3 µM -0.773073210849697 0.330249241964952 no 2278 0.219739527177794 881 6753853
SGTC_1358 1509-0022 2.48 µM -0.773565778147487 0.330137508369196 no 2279 0.219593808042371 874 3258434
SGTC_1674 st016616 23.6 µM -0.774664334567999 0.32988836723282 no 2280 0.21926901550293 856 625830
SGTC_2292 7671323 168.05 µM -0.776246189231083 0.3295297516455 no 2281 0.218801819316612 883 937504
SGTC_2755 lomerizine 42.69 µM -0.777074242879928 0.329342089568004 no 2282 0.218557484653561 859 3949 A calcium channel blocker.
SGTC_2915 7971052 15.16 µM -0.777604559807631 0.329221926239059 no 2283 0.218401086035155 831 5741558
SGTC_66 0109-0187 42.4 µM -0.778096063196177 0.329110573333383 no 2284 0.218256191701533 850 759417
SGTC_1586 deoxycorticosterone acetate 53.7 µM -0.779087218738077 0.32888606749347 no 2285 0.217964169317935 882 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE.
SGTC_1298 1079-1278 263 µM -0.781423361346687 0.328357154026356 no 2286 0.217276767774794 868 2840950
SGTC_1574 spiramycin 23.7 µM -0.781992892107953 0.328228261722688 no 2287 0.21710937542451 873 6419898 An antibiotic and protein synthesis inhibitor.
SGTC_527 4476-4215 268 µM -0.782235767833039 0.328173301969026 no 2288 0.21703801382188 844 4418754
SGTC_466 geldanamycin 89.2 µM -0.78257699752932 0.328096092219646 no 2289 0.21693777681629 833 5288382 HSP90 inhibitor.
SGTC_1216 1165-0504 9.65 µM -0.782713037131578 0.328065312703589 no 2290 0.216897822332885 879 6304004
SGTC_638 3970-0837 4.09 µM -0.783189663342496 0.327957483287342 no 2291 0.216757871997349 851 4118451 YLR208W SEC13
SGTC_284 0988-0104 32.6 µM -0.784008029113819 0.327772373954593 no 2292 0.216517699532217 872 4666532
SGTC_2545 solidagenone 89.61 µM -0.784239316177762 0.327720065902382 no 2293 0.216449849752545 806 6708572 An anti ulcer agent
SGTC_1949 st076024 69.1 µM -0.785035297966154 0.327540071918767 no 2294 0.216216436637045 878 2921930
SGTC_2279 7948423 32.93 µM -0.785223968835747 0.327497413975599 no 2295 0.216161132303935 845 1247112
SGTC_1204 4049-0315 18.3 µM -0.788101096854694 0.326847182870207 no 2296 0.215318786835647 883 588402
SGTC_2492 derrusnin 100 µM -0.789954169134793 0.326428666479794 no 2297 0.214777267191766 880 1715307 Part of coumarin class of compounds.
SGTC_1328 1441-0025 69.2 µM -0.79174307852384 0.326024848454045 no 2298 0.214255249188016 875 4562601
SGTC_1076 itraconazole 331 nM -0.791759126551214 0.326021226787793 no 2299 0.214250569588655 862 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1
SGTC_1263 0774-1208 64.8 µM -0.79262849194994 0.325825055786696 no 2300 0.213997151801832 873 906585
SGTC_316 k060-0003 58.6 µM -0.793051306932505 0.325729665641177 no 2301 0.213873965408551 880 6152314
SGTC_596 1155-0152 116 µM -0.794201307123599 0.3254702749362 no 2302 0.213539123844667 861 280313
SGTC_2933 9026794 32.47 µM -0.794654818573571 0.325368005437903 no 2303 0.21340716052438 869 17586027
SGTC_2244 6635614 200 µM -0.794719430594097 0.325353436117349 no 2304 0.213388363508575 883 836499
SGTC_1019 4262-0212 3.4 µM -0.794801541643771 0.32533492133775 no 2305 0.213364477044377 873 4677213
SGTC_2811 7967822 32.47 µM -0.795311811374286 0.325219873022054 no 2306 0.213216072289281 860 2232244
SGTC_2281 7943571 200 µM -0.795527726041841 0.325171196688086 no 2307 0.213153294682255 864 1244024
SGTC_935 2996-0153 430 µM -0.796048929478326 0.325053707596645 no 2308 0.213001798205342 857 23738523
SGTC_443 clozapine 122 µM -0.796688029487683 0.324909666133739 no 2309 0.212816118897491 882 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_1273 0849-0096 14.1 µM -0.797741241929968 0.324672348405737 no 2310 0.212510332716249 873 5286025
SGTC_2624 nerol 100 µM -0.799052238697593 0.324377044200237 no 2311 0.21213006109827 883 637566 A natural product oil.
SGTC_2688 kanamycin b 96.69 µM -0.800357271261764 0.324083193097275 no 2312 0.211751914908423 852 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis.
SGTC_1903 st060211 78.3 µM -0.804359028410514 0.323182810623709 no 2313 0.210594828092634 844 688960
SGTC_2528 xanthyletin 44.79 µM -0.805681495572266 0.32288548701232 no 2314 0.210213260899872 884 65188 An natural product with antifungal activity of unknown mechanism.
SGTC_1706 st031321 9.9705 µM -0.809991134227751 0.321917358790662 no 2315 0.208972635627942 870 6103185
SGTC_1292 0kpi-0043 232 µM -0.810136821703182 0.321884652248709 no 2316 0.208930771748452 864 3333905
SGTC_2144 5628481 200 µM -0.812614108240439 0.321328717848192 no 2317 0.208219670083118 858 2818399
SGTC_1059 3448-6867 171 µM -0.813943766098948 0.32103049072981 no 2318 0.207838583323052 875 3934407
SGTC_657 3534-0529 86.7 µM -0.814382543971346 0.320932103165423 no 2319 0.207712917781927 892 1049549
SGTC_1157 4092-0394 27.6 µM -0.815327977352629 0.320720150510436 no 2320 0.207442299213387 882 3659885
SGTC_3150 9097574 49.47 µM -0.816178126093709 0.320529609201735 no 2321 0.207199132746017 856 17217476
SGTC_1117 retinoic acid 1.10837 µM -0.817345338652469 0.320268082361677 no 2322 0.206865551870569 874 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR).
SGTC_1772 st048439 82.2 µM -0.821014142739204 0.319446628002537 no 2323 0.205819106242513 867 2927068 YDL195W SEC31
SGTC_1809 st050081 57.6 µM -0.821798727343104 0.31927107232655 no 2324 0.205595729091418 873 5036894
SGTC_843 0310-0051 143 µM -0.823047789029607 0.318991670620325 no 2325 0.20524040889824 870 2065037
SGTC_2174 5790901 200 µM -0.823897098905652 0.318801747820393 no 2326 0.204999014492706 890 786020
SGTC_3177 9107506 49.47 µM -0.825645243466419 0.318410977266117 no 2327 0.204502681063522 861 8897194
SGTC_121 0557-0495 61.343 µM -0.826578782493877 0.318202381806727 no 2328 0.204237923726784 896 3104427
SGTC_2645 abamectin 100 µM -0.827549554836177 0.317985527850745 no 2329 0.203962823396454 844 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels.
SGTC_2828 7998861 71.43 µM -0.828100669037058 0.317862446113947 no 2330 0.20380674533069 824 2988188
SGTC_1770 st043884 66.3 µM -0.829221723910573 0.31761214017723 no 2331 0.20348947723839 909 670149
SGTC_2787 5284540 71.43 µM -0.831710690678091 0.317056708853338 no 2332 0.20278613241341 883 736958
SGTC_1106 tegaserod maleate 11.7 µM -0.832445159330353 0.31689288540446 no 2333 0.20257886041371 883 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation.
SGTC_1201 1889-3372 45.9 µM -0.8329985967717 0.316769464731808 no 2334 0.202422760336555 861 5392199
SGTC_201 4262-0159 12.803 µM -0.833150904567602 0.316735502536148 no 2335 0.20237981370824 884 1341029
SGTC_874 0599-0792 117 µM -0.834225057525549 0.316496027527601 no 2336 0.202077086737949 872 765305
SGTC_2332 7982454 138.89 µM -0.834854891112306 0.316355646228247 no 2337 0.201899707750795 899 2981748
SGTC_1886 st057356 49.9 µM -0.837170934579125 0.315839659456672 no 2338 0.201248246309145 884 24207747
SGTC_2239 6685329 187.64 µM -0.840132915971398 0.315180288145894 no 2339 0.200416933170689 869 805680
SGTC_1724 st037281 8.293 µM -0.84087084490523 0.315016108101954 no 2340 0.20021014658406 868 574124 YDL195W SEC31
SGTC_2781 5567276 71.43 µM -0.843900167111276 0.31434250464114 no 2341 0.199362597406237 903 2853274
SGTC_3250 9135583 49.47 µM -0.844054663741168 0.314308167136278 no 2342 0.199319430039476 886 7699353
SGTC_1094 duloxetine 25.4 µM -0.844127972884731 0.314291874442808 no 2343 0.19929894895539 864 60834 A selective serotonin reuptake inhibitor.
SGTC_3355 9151058 44.0485 µM -0.844364543721368 0.314239299893051 no 2344 0.199232864518079 879 17015728
SGTC_864 0469-0573 172 µM -0.844804258428619 0.314141589480632 no 2345 0.199110068304251 914 689425
SGTC_2238 6671620 73.2395 µM -0.845349929573812 0.314020352261084 no 2346 0.198957745754254 868 729941
SGTC_308 4092-1169 104 µM -0.845684490859726 0.313946029355952 no 2347 0.198864388659537 902 2268590 YDL196W YDL196W
SGTC_2134 5324836 1.464 µM -0.846031262497579 0.313869001882153 no 2348 0.198767652221116 899 699272
SGTC_147 4466-0538 29.23 µM -0.846570161777146 0.31374931369673 no 2349 0.198617375604924 877 6742687 YHR072W ERG7
SGTC_1054 3429-0080 167 µM -0.847959183478858 0.313440905826746 no 2350 0.198230351221238 892 1162877
SGTC_1865 st057639 52.2 µM -0.848233492077223 0.313380015831711 no 2351 0.19815397422833 893 688818
SGTC_697 0508-1955 564 µM -0.84887999265648 0.313236528177331 no 2352 0.197974036419694 873 6243113
SGTC_1042 0350-0096 82 µM -0.849241601061067 0.313156283280627 no 2353 0.197873434512275 888 3122515
SGTC_838 0109-0203 71.4 µM -0.849531990230833 0.313091849123485 no 2354 0.197792668641122 868 759422
SGTC_1245 0418-0076 17.2 µM -0.850960177272299 0.312775033246341 no 2355 0.197395737285685 893 6790114
SGTC_2222 6885208 172.143 µM -0.852450902065388 0.312444492029236 no 2356 0.196981939258725 889 609514
SGTC_963 1269-2853 151 µM -0.852816879704223 0.312363366170217 no 2357 0.196880430871808 875 3668223
SGTC_2978 9011784 42.97 µM -0.853468004481314 0.31221905454544 no 2358 0.196699911744169 872 2994934
SGTC_1553 gossypol 38.6 µM -0.853535055007255 0.312204195480408 no 2359 0.19668132821816 862 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_1132 3456-3614 2.5 µM -0.854379653170876 0.312017050271991 no 2360 0.196447332961215 907 3125502
SGTC_2710 st078562 53.7235 µM -0.854856717747989 0.31191136422038 no 2361 0.19631523718904 887 17250908
SGTC_3025 9087895 49.47 µM -0.855384319786964 0.311794500431162 no 2362 0.196169210676446 899 17173641
SGTC_2076 5212012 200 µM -0.857194045177151 0.311393790492934 no 2363 0.195668826456611 881 604802
SGTC_2127 5253358 187.912 µM -0.859548535802511 0.310872792808055 no 2364 0.195018977177362 887 20612
SGTC_171 k064-0041 9.68 µM -0.860292265708535 0.310708300216136 no 2365 0.194813977613351 871 53325
SGTC_1343 1487-0095 224 µM -0.864084956175679 0.309870050354217 no 2366 0.193770611258294 904 4560101 YGL055W OLE1
SGTC_2406 ethylparaben 405.7 µM -0.867460039131043 0.309124929083585 no 2367 0.192844998905547 927 8434 A possible steroid mimic.
SGTC_3262 9137218 49.47 µM -0.868220574319076 0.308957132983937 no 2368 0.192636796555808 848 17650664
SGTC_2502 avocadyne acetate 18.59 µM -0.86999935715723 0.308564837624579 no 2369 0.192150377756952 873 3952079
SGTC_1190 1486-1332 13 µM -0.870093614507556 0.308544056060996 no 2370 0.192124623502529 883 4150046
SGTC_739 1486-1183 203 µM -0.870836176718125 0.308380359736456 no 2371 0.191921804585536 891 4346692
SGTC_3333 9141820 12.094 µM -0.872559169074434 0.30800067635841 no 2372 0.191451702055054 882 1939433
SGTC_2902 5787006 60.46 µM -0.872804665421137 0.307946594812602 no 2373 0.191384778120591 892 591003
SGTC_981 1488-1094 54.9 µM -0.873047806915491 0.307893036139407 no 2374 0.191318510267148 879 3449522
SGTC_1149 3909-7961 23.3 µM -0.87458133482371 0.307555328324662 no 2375 0.190900873668187 896 735261
SGTC_1495 4469-0029 237 µM -0.881261853852058 0.306086074242807 no 2376 0.189088053818508 875 793680
SGTC_2557 derrustone 83.84 µM -0.881622824538545 0.306006774025167 no 2377 0.188990403988051 900 629853 An antioxidant.
SGTC_3309 9129340 25.759 µM -0.88630764852022 0.304978409394186 no 2378 0.18772588431932 879 17158987
SGTC_1711 st032263 62.8 µM -0.887959866034199 0.304616098004163 no 2379 0.187281170086081 912 3958979
SGTC_450 aminopyrene 156 nM -0.88932837512241 0.304316145492457 no 2380 0.186913313028094 888 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1
SGTC_2955 9076254 12.21 µM -0.890142366737632 0.304137795613061 no 2381 0.18669472320688 886 16459619
SGTC_3323 9138564 53.9225 µM -0.890687116718532 0.304018464024218 no 2382 0.186548524135314 899 43912313 YNL103W MET4
SGTC_1961 st076550 68.7 µM -0.893699676998411 0.303358917225499 no 2383 0.185741299128327 907 1579337
SGTC_1241 0364-0022 50.8 µM -0.895187083888943 0.3030335117557 no 2384 0.18534354402055 921 4563895
SGTC_2193 5925765 200 µM -0.89638944284372 0.302770581477683 no 2385 0.185022401873671 907 877370
SGTC_968 1309-0633 340 µM -0.896569979976608 0.302731110678586 no 2386 0.184974211465096 901 3761976
SGTC_477 mead ethanolamide 10 µM -0.897631658709739 0.302499042705452 no 2387 0.184690977535524 876 16061185
SGTC_1013 4112-3890 241 µM -0.898350924591455 0.302341866678433 no 2388 0.18449924557345 898 705171
SGTC_2062 5245942 200 µM -0.899038141084918 0.302191728406592 no 2389 0.184316172587678 916 1376160
SGTC_3133 9127736 49.47 µM -0.90229614697402 0.301480397825907 no 2390 0.183449785902253 885 27243420
SGTC_371 0195-0006 7.36 µM -0.906026664921136 0.300666828894048 no 2391 0.182460869500706 886 3928593
SGTC_1001 4048-4355 44.4 µM -0.907247900823523 0.300400711477753 no 2392 0.18213785909643 900 21824233
SGTC_1072 oxiconazole 14.9 nM -0.907440986756589 0.300358646198565 no 2393 0.182086821638337 880 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_2982 9019404 25.97 µM -0.907720501437709 0.300297756457338 no 2394 0.182012954734257 891 22333232
SGTC_1033 k072-0102 21.3 µM -0.908641673616005 0.300097126945375 no 2395 0.181769650663123 894 5965931
SGTC_80 0159-0065 512.242 µM -0.909758528397693 0.299853959491 no 2396 0.181474935061474 891 1548079
SGTC_1185 1319-0113 81.3 µM -0.910390502734492 0.299716402268603 no 2397 0.181308302286489 909 4672763
SGTC_376 3970-0862 59.1 µM -0.911315248354362 0.299515171194915 no 2398 0.181064647192899 916 3135186
SGTC_2751 anetholtrithion 17.25 µM -0.912322462282566 0.299296064147407 no 2399 0.180799496595011 921 2194 A chloretic substance that stimulates the liver to produce bile.
SGTC_903 1134-0042 114 µM -0.913159367407065 0.299114061020938 no 2400 0.180579365295273 896 701009
SGTC_209 4077-0173 175.592 µM -0.913318490490071 0.299079461948799 no 2401 0.180537530149021 895 15993494
SGTC_152 4469-0003 551.229 µM -0.913334629657607 0.299075952815731 no 2402 0.180533287330271 887 697280
SGTC_926 2268-1401 59.4 µM -0.915098299883095 0.298692591358241 no 2403 0.180070013713088 911 2931578
SGTC_1628 st004252 77.7 µM -0.915369633882783 0.298633632480977 no 2404 0.179998807121514 886 692968
SGTC_604 1000-0114 314 µM -0.915825182576731 0.298534657012062 no 2405 0.179879296557221 920 1572745
SGTC_2339 9000433 200 µM -0.916373144688098 0.298415622977316 no 2406 0.179735607912289 911 2988954
SGTC_2686 alizarin 95.37 µM -0.916846727471917 0.298312763798505 no 2407 0.179611481399612 877 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1
SGTC_435 c-PAF 6.7 µM -0.918515087668733 0.297950535193532 no 2408 0.179174631861527 884 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase
SGTC_1578 josamycin 24.2 µM -0.919013465360147 0.297842368056242 no 2409 0.179044264571673 895 5282165 A P450 substrate.
SGTC_751 0833-0568 350 µM -0.919700339672477 0.297693319254259 no 2410 0.178864687545573 909 6954252
SGTC_1733 st037357 54.9 µM -0.925317248787551 0.296475753074931 no 2411 0.177400454530281 925 1272339 YGL099W LSG1
SGTC_314 1671-0008 2.74 µM -0.925412967512625 0.296455024108065 no 2412 0.177375568039466 911 3913060
SGTC_510 ag-490 170 µM -0.927742114282269 0.295950826038285 no 2413 0.176770678566891 904 5328779
SGTC_609 0986-0026 86.3 µM -0.928356972136837 0.295817791450247 no 2414 0.176611215139976 885 2848610
SGTC_807 1315-0151 48 µM -0.930497316736788 0.295354907160013 no 2415 0.176056826389976 932 4011080
SGTC_2783 7738165 71.43 µM -0.932510954718919 0.294919729735728 no 2416 0.175536263985889 912 17201110
SGTC_2035 5154463 94.595 µM -0.933276089610636 0.294754450092705 no 2417 0.17533871858238 914 2769623
SGTC_3111 9122088 49.47 µM -0.933629074041337 0.294678215008241 no 2418 0.17524763126709 885 16876704
SGTC_250 brefeldin a 552.239 µM -0.933911595374167 0.294617204599065 no 2419 0.175174748515336 908 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.
SGTC_3232 9132874 49.47 µM -0.934469790623603 0.294496679612141 no 2420 0.175030805981368 898 3784940
SGTC_588 3970-1144 52.9 µM -0.937487296243414 0.293845537020751 no 2421 0.174253977704333 892 1888707
SGTC_1236 0330-0013 258 µM -0.93901457518505 0.293516222044924 no 2422 0.173861630564979 928 4617066
SGTC_1587 estradiol valerate 56.1 µM -0.939815330019487 0.293343629994761 no 2423 0.173656146998364 927 13791 A steroid.
SGTC_1748 st037455 53.6035 µM -0.9401552421503 0.293270380679179 no 2424 0.173568968088472 911 580690
SGTC_595 3909-8003 73.7 µM -0.94086173233962 0.293118162807328 no 2425 0.173387860245236 929 699517
SGTC_549 1661-1316 519 µM -0.941734876374532 0.29293008893001 no 2426 0.173164197180322 917 2857282
SGTC_2462 5162487 171.77 µM -0.942522631138615 0.292760455839844 no 2427 0.172962565030281 923 2259986
SGTC_1438 4092-1045 4 µM -0.946656172786486 0.291871098130314 no 2428 0.171907005061422 904 1351342
SGTC_1440 4100-1550 40 µM -0.947560584017126 0.291676676240726 no 2429 0.171676600095707 912 742806
SGTC_2578 7,8-dihydroxyflavone 64.44 µM -0.948997079769188 0.291367995930108 no 2430 0.171311048655746 895 1880 Intensifies effect of antibiotics on Staphylococcus aureus.
SGTC_1576 erythromycin ethylsuccinate 23.2 µM -0.951531026730103 0.290823862554566 no 2431 0.170667437991227 901 3256 An antibiotic and ribosome inhibitor.
SGTC_7 0192-1582 4.227 µM -0.95153804895908 0.290822355279132 no 2432 0.170665656531385 947 252616
SGTC_761 k216-0224 480 µM -0.952539804734162 0.290607372396912 no 2433 0.170411644427682 935 1340404
SGTC_2414 st077232 92.9 µM -0.953492550170388 0.290402976440623 no 2434 0.170170284499881 895 729801
SGTC_1998 st075797 76.8 µM -0.954303769939324 0.29022899557102 no 2435 0.169964950151765 898 24208315
SGTC_2402 5553605 200 µM -0.955484707915932 0.289975809207547 no 2436 0.169666317492119 936 6758546
SGTC_194 1486-1323 56.904 µM -0.956811815825637 0.289691408486088 no 2437 0.169331123628864 918 5178754
SGTC_2595 hexamethylquercetagetin 100 µM -0.959385427263607 0.2891402540637 no 2438 0.168682306839448 945 386331
SGTC_1745 st081495 74 µM -0.960164836105167 0.288973436282334 no 2439 0.168486130675737 897 13842402 YBL026W LSM2
SGTC_1251 0490-5699 265 µM -0.960914767835271 0.288812970279331 no 2440 0.168297512396672 917 3883818
SGTC_2919 7978188 46.38 µM -0.963844168869978 0.288186556478545 no 2441 0.167562029286571 887 2980291
SGTC_205 1486-1330 71.903 µM -0.9642223266066 0.288105739164067 no 2442 0.167467236547313 929 4118834
SGTC_2240 6690706 185.951 µM -0.96868324505877 0.287153189997662 no 2443 0.166351627379816 917 805876
SGTC_2263 7948595 193.29 µM -0.970405577631411 0.286785816120329 no 2444 0.165922184785902 903 2971371
SGTC_1519 esterone 74 µM -0.971201586778935 0.286616102520537 no 2445 0.1657239519368 923 698 A steroid.
SGTC_2125 5246583 200 µM -0.971891185467035 0.286469114743514 no 2446 0.165552342686388 912 835267
SGTC_735 3076-0345 636 µM -0.973354090491771 0.286157415406927 no 2447 0.165188673893132 919 2888990
SGTC_2426 5582046 32.21 µM -0.974887101564607 0.285830951630512 no 2448 0.164808132447379 932 2251934
SGTC_1200 1643-0193 18.4 µM -0.976042100305952 0.28558510486204 no 2449 0.164521800897852 924 5403974
SGTC_3001 9076041 71.4286 µM -0.976891717147111 0.285404324295012 no 2450 0.164311381404364 920 16004211
SGTC_2998 9066762 71.4286 µM -0.977660060061211 0.285240884048736 no 2451 0.164121240857186 911 4945196
SGTC_28 pentachloropyridine N-oxide 1.606 µM -0.980606558058423 0.284614525136049 no 2452 0.163393399536781 921 140250 A respiratory chain inhibitor.
SGTC_988 1497-1057 103 µM -0.981395208556847 0.28444698733743 no 2453 0.163198944035008 918 3533044
SGTC_1649 st011737 51.3 µM -0.981666833876411 0.284389295236985 no 2454 0.16313200491773 872 1761035
SGTC_782 0083-0095 30.5 µM -0.98219680044334 0.284276748617991 no 2455 0.163001451778259 939 3591729 An indicator and reagent.
SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM -0.984543320772766 0.283778684635995 no 2456 0.162424221132051 932 16623 A steroid.
SGTC_870 0573-2213 57.6 µM -0.985262461943373 0.283626126002737 no 2457 0.162247583157784 907 3916321
SGTC_2314 7727897 200 µM -0.98686466603796 0.283286375718386 no 2458 0.161854494056459 886 900724
SGTC_2195 6536160 144.242 µM -0.987635251688356 0.28312304117492 no 2459 0.161665657655614 917 3834386
SGTC_134 0269-0018 6.916 µM -0.988770247916374 0.282882547923594 no 2460 0.161387781999142 930 4378915
SGTC_1716 st033144 30.6155 µM -0.990883833990699 0.282434963840032 no 2461 0.160871153511996 925 674617
SGTC_701 4424-0219 185 µM -0.991036443574217 0.282402659622038 no 2462 0.160833892654197 940 2911779
SGTC_3009 9080819 71.4286 µM -0.996898698440303 0.281163091676733 no 2463 0.159406841760791 945 17027216
SGTC_1750 st081859 2.357 µM -0.996955309962336 0.281151134048774 no 2464 0.159393101335008 921 5291695
SGTC_1807 st050092 58.9 µM -0.997648330761262 0.281004772364942 no 2465 0.159224958131548 932 5008496
SGTC_579 4491-1009 110 µM -0.998403774335565 0.28084526933223 no 2466 0.15904180207485 960 1271041
SGTC_816 0325-0417 81.3 µM -0.998903701017804 0.280739739761701 no 2467 0.158920671599293 913 68101
SGTC_2682 pyrogallin 40.03 µM -0.999668472426663 0.280578341210838 no 2468 0.158735487196141 920 822798 An ATP competetive kinase inhibitor.
SGTC_1319 1306-0155 43.7 µM -0.999744776798184 0.280562240280977 no 2469 0.158717018355366 929 3122360
SGTC_2201 6605497 169.863 µM -1.00119334941958 0.280256662870198 no 2470 0.158366670600933 931 670741
SGTC_2681 menadione 3.18 µM -1.00126631549024 0.280241274892293 no 2471 0.158349036661434 938 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_2156 5649887 115 µM -1.00204459913527 0.28007716638349 no 2472 0.158161026562461 946 54680440 YKL052C | YBR257W ASK1 | POP4
SGTC_494 Boc-Gly-Val-Val-CHO 140 µM -1.00338081316974 0.279795521625953 no 2473 0.157838578966991 940 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA.
SGTC_2433 5607874 27.82 µM -1.00449133042084 0.279561553419702 no 2474 0.157570923969923 916 2252428
SGTC_1867 st057372 64 µM -1.00563257710973 0.279321210020443 no 2475 0.15729617351955 910 688837
SGTC_1071 trifluoperazine 6.31 µM -1.00621277552753 0.27919906034252 no 2476 0.157156613968936 957 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels.
SGTC_1217 1183-1422 255 µM -1.00776161769518 0.278873108479905 no 2477 0.15678445808725 910 2849664
SGTC_619 1652-1634 108 µM -1.01015973284995 0.278368793776938 no 2478 0.156209383928286 948 5400454
SGTC_2453 5731132 22.18 µM -1.01070743854597 0.278253675686669 no 2479 0.156078237884128 953 1362040
SGTC_2350 9023895 38.85 µM -1.01077335493721 0.278239822787209 no 2480 0.15606245934819 907 2997209
SGTC_1260 0700-1617 7.75 µM -1.01108447330106 0.278174443112956 no 2481 0.155988000525045 913 2853078
SGTC_2184 6075246 200 µM -1.01280443597931 0.27781313843972 no 2482 0.155576790723213 913 2267320
SGTC_1664 st014217 9.02 µM -1.01417159151778 0.277526109885103 no 2483 0.15525044082831 916 3982782
SGTC_2692 st077426 47.7 µM -1.01438746977224 0.277480800405727 no 2484 0.155198950468822 943 25238571
SGTC_1209 2323-2347 50.3 µM -1.02178156173807 0.275931082297178 no 2485 0.153442149001323 898 5412760
SGTC_249 wiskostatin 11.211 µM -1.02691783443905 0.274857085746225 no 2486 0.15222957784231 903 2775510 A n-wasp and actin depolymerizer.
SGTC_2317 5986382 200 µM -1.02835329767243 0.274557298640907 no 2487 0.15189183427528 965 877883
SGTC_2078 5212016 200 µM -1.02840633002299 0.274546226272072 no 2488 0.151879366079539 928 1899708
SGTC_225 nsc-122657 1.016 µM -1.03070746260719 0.274065996170374 no 2489 0.151339012075783 937 275685
SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM -1.03206170786308 0.273783568899706 no 2490 0.151021605361543 914 1241132 A phosphatase inhibitor.
SGTC_1088 bifonazole 369 nM -1.03544678804547 0.273078242028213 no 2491 0.150230152398758 926 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase.
SGTC_2355 9061122 103.12 µM -1.03692436131345 0.272770652420309 no 2492 0.149885554737197 967 5302957
SGTC_2929 9013348 24.6 µM -1.04080968720071 0.271962656912154 no 2493 0.148981941609827 938 2995952
SGTC_2397 5161689 200 µM -1.04365787655413 0.271371102303959 no 2494 0.148321852642656 957 2259942
SGTC_3316 9136639 10.545 µM -1.04399066642287 0.271302025378406 no 2495 0.148244853970395 925 4903665
SGTC_3298 9116858 71.43 µM -1.04818298489635 0.270432580497547 no 2496 0.147277154178067 982 2506942
SGTC_633 0437-0093 97.7 µM -1.04840860609632 0.27038582843515 no 2497 0.147225195075695 936 2831118
SGTC_718 1130-0073 349 µM -1.05010091014893 0.270035286749251 no 2498 0.146835860163789 952 6740020
SGTC_1825 st052143 62.6 µM -1.05098416501664 0.269852420826948 no 2499 0.146632931307521 955 674173
SGTC_104 0074-0074 590.992 µM -1.05236574015203 0.269566508848684 no 2500 0.146315890371266 931 3943124
SGTC_3013 9080133 71.4286 µM -1.05313114875075 0.269408175674796 no 2501 0.146140444313413 953 17050193
SGTC_2110 5483698 200 µM -1.05733564218942 0.268539262347043 no 2502 0.145179216067357 929 2848765 YHR062C RPP1
SGTC_1946 st076057 65.1 µM -1.05866409913361 0.268265012577211 no 2503 0.144876391707274 920 953009
SGTC_3038 9091290 49.47 µM -1.059351097647 0.268123242287566 no 2504 0.144719956009176 940 25236843
SGTC_2840 9008771 71.43 µM -1.06065745162303 0.267853764720405 no 2505 0.144422801494223 907 2992978
SGTC_1395 3486-0190 4.35 µM -1.06576209558972 0.266802077328237 no 2506 0.143265599746817 957 6748079
SGTC_1120 ficusin 1.78878 µM -1.06580974783748 0.266792269584206 no 2507 0.143254826763528 958 6199 A DNA cross-linker.
SGTC_2273 7815444 169.05 µM -1.06626985594655 0.2666975799085 no 2508 0.143150835954555 962 2824616
SGTC_819 1013-0258 27.7 µM -1.06670322552575 0.266608408527592 no 2509 0.143052935069228 948 5753198
SGTC_3182 9108849 49.47 µM -1.06734086853187 0.266477232668666 no 2510 0.142908969809307 930 17133045
SGTC_3032 9089427 49.47 µM -1.06811897231382 0.266317205470194 no 2511 0.142733424393326 897 17173707
SGTC_1116 jasmonic acid 1.58368 µM -1.07091113377756 0.265743361691795 no 2512 0.142104694600504 945 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid.
SGTC_913 3487-1245 167 µM -1.07137943821865 0.265647177392075 no 2513 0.141999427181946 932 4016153
SGTC_1504 k297-0033 30 µM -1.07178032540855 0.265564853840639 no 2514 0.141909356041092 888 4388117
SGTC_2562 3',7'-dimethoxyflavone 64.92 µM -1.07400243651221 0.265108770528319 no 2515 0.141410794761005 935 688664
SGTC_2351 9026858 72.31 µM -1.07435643362185 0.265036150172285 no 2516 0.141331480378023 982 1409300
SGTC_2463 5473429 200 µM -1.07445814718975 0.2650152861211 no 2517 0.141308696648605 933 5399405
SGTC_543 3844-1095 191 µM -1.07459853259186 0.264986490859553 no 2518 0.141277254559808 957 4230703
SGTC_1703 st026983 48.3 µM -1.07582260677781 0.26473548130724 no 2519 0.14100329988765 931 1104023
SGTC_51 1013-0126 23.419 µM -1.07865233768171 0.264155677785105 no 2520 0.140371370200345 923 1627850
SGTC_1557 sumaresinolic acid 42.3 µM -1.08370552098806 0.263121906733892 no 2521 0.139247693462511 935 9982268 A natural terpine and antifungal of unknown mechanisn.
SGTC_3264 9137442 49.47 µM -1.08438335466371 0.262983394159227 no 2522 0.139097430440254 942 17015726
SGTC_1017 4239-0030 168 µM -1.0858416532389 0.262685523136614 no 2523 0.138774527241162 927 1149593
SGTC_1070 indatraline 8.81 µM -1.08695640986142 0.262457940210492 no 2524 0.138528037239229 945 10314472 A monamine transport inhibitor. YGL099W LSG1
SGTC_2789 5281112 71.43 µM -1.08792664248565 0.262259944747893 no 2525 0.13831374669038 937 765948
SGTC_1452 4194-0072 190 µM -1.09078236576803 0.26167762139117 no 2526 0.137684328842475 955 1343545
SGTC_910 3454-3003 490 µM -1.09152952186399 0.261525375015964 no 2527 0.137519974462265 960 820824
SGTC_72 0744-0168 198.391 µM -1.09369426242315 0.261084527415015 no 2528 0.137044545758918 971 677577
SGTC_2278 7948257 134.34 µM -1.09479132537409 0.260861257405309 no 2529 0.136804033833573 939 1247028
SGTC_856 0433-0016 11.3 µM -1.0955193552815 0.260713145805659 no 2530 0.136644585332877 953 3911780
SGTC_1433 4060-0023 7.6 µM -1.09830146298654 0.260147548182348 no 2531 0.136036436650046 951 3840627
SGTC_3302 9125395 16.351 µM -1.09922652955783 0.259959623982011 no 2532 0.135834634851918 932 17599668
SGTC_524 r073-0010 27.8 µM -1.09989297573581 0.259824281057329 no 2533 0.135689377787767 958 2772106
SGTC_2024 5144227 134 µM -1.10117738101679 0.259563544626882 no 2534 0.135409732011999 948 3475211
SGTC_2634 4'-methoxyflavone 100 µM -1.10134560304821 0.259529405280651 no 2535 0.135373135323705 959 77793 From seeds of Psoralea corylifolia (Fabaceae)
SGTC_1007 4101-0031 70 µM -1.1026349281421 0.259267823843635 no 2536 0.135092867856754 977 1146276
SGTC_82 0054-0107 293.755 µM -1.10285469831773 0.259223249926925 no 2537 0.135045134963335 946 3104697
SGTC_3210 9128157 49.47 µM -1.10303776156952 0.259186123954117 no 2538 0.135005383446275 954 17590849
SGTC_2237 6667747 47.222 µM -1.10497849066056 0.258792705282253 no 2539 0.134584454716482 973 729940 YDL015C TSC13
SGTC_1187 1391-0724 117 µM -1.10549226689354 0.258688605893868 no 2540 0.134473171697788 961 6997986
SGTC_1336 1486-0901 104 µM -1.10555544056292 0.258675807381688 no 2541 0.134459492755902 946 5006114
SGTC_3157 9099274 49.47 µM -1.10692765226876 0.25839788848044 no 2542 0.134162604624537 939 17217662
SGTC_849 0386-0493 241 µM -1.10707837743953 0.258367371009528 no 2543 0.134130021589771 963 726119
SGTC_2226 7298446 200 µM -1.10766339501356 0.258248939629719 no 2544 0.134003606833439 959 3283010
SGTC_2015 5119600 184 µM -1.10818052588943 0.258144274716811 no 2545 0.133891929705544 959 2828786
SGTC_1714 st033236 13.627 µM -1.11017102693234 0.257741611803162 no 2546 0.13346266759197 961 2916566
SGTC_3091 9116372 49.47 µM -1.11083639664583 0.257607085417436 no 2547 0.133319388406844 969 17169793
SGTC_1656 st012921 11 µM -1.11373940866553 0.257020572862487 no 2548 0.132695498784571 939 6732821
SGTC_3152 9099253 49.47 µM -1.11501362852983 0.256763354274688 no 2549 0.132422290795526 928 25236131
SGTC_1550 gossypolone 36.6 µM -1.11528210592064 0.256709175562842 no 2550 0.132364775507597 958 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_1278 0874-0585 172 µM -1.11632124746206 0.256499533013463 no 2551 0.13214232492032 966 766306
SGTC_2856 9022925 19.48 µM -1.1170830748402 0.256345894142725 no 2552 0.131979403238361 956 4944862
SGTC_349 k015-0014 24 µM -1.12709933176991 0.254330370105426 no 2553 0.129850242927981 955 2196908
SGTC_1529 apigenin 74 µM -1.12761523594121 0.254226782563516 no 2554 0.129741224680013 963 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_1514 1189-1591 158 µM -1.12843422412746 0.254062384732249 no 2555 0.129568290469214 967 767698 YMR146C TIF34
SGTC_2623 humulene 100 µM -1.12961497196577 0.253825468053631 no 2556 0.129319249731276 974 6187145 An anti-inflammatory.
SGTC_1421 4029-0249 71.4 µM -1.12993597375531 0.253761079203094 no 2557 0.129251602132686 959 2894095
SGTC_2046 4110841 106 µM -1.13275532655992 0.253195921761813 no 2558 0.128658508249719 945 44119630 YMR134W ERG29
SGTC_1291 0993-0025 5.79 µM -1.13316080164158 0.253114696146678 no 2559 0.12857336595588 961 4353356
SGTC_2243 6634756 200 µM -1.13546554406042 0.252653265828412 no 2560 0.128090155375192 959 885676
SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM -1.13686260345756 0.252373777708014 no 2561 0.127797863766107 957 1377
SGTC_2863 9028737 58.44 µM -1.13693216879587 0.252359865104727 no 2562 0.127783321489081 956 6460917
SGTC_2119 5528445 120.635 µM -1.13913776151091 0.251918970978672 no 2563 0.127322849838096 977 791935
SGTC_2536 dehydroabietamide 32.04 µM -1.14050484518487 0.251645897569418 no 2564 0.127038017638624 962 3983547
SGTC_439 amiodarone 34.4 µM -1.14112386782218 0.251522299946852 no 2565 0.12690919009789 954 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1
SGTC_2931 9014674 55.67 µM -1.14153608968212 0.251440011153175 no 2566 0.12682345124277 983 2996810
SGTC_821 1114-0266 29.2 µM -1.14277968136343 0.251191848399121 no 2567 0.12656503848118 949 3123235
SGTC_71 0417-1750 47.813 µM -1.1437321687868 0.251001864080939 no 2568 0.126367364062652 917 6811472
SGTC_2504 purpurogallin 52.29 µM -1.14406001557738 0.25093648894894 no 2569 0.126299374192163 954 5281571 An antioxidant.
SGTC_2514 salinomycin 42.74 µM -1.14433062568572 0.250882534034525 no 2570 0.126243273448291 974 23682228 A polyether potassium ionophore.
SGTC_416 estradiol valerate 100 µM -1.14603958664244 0.250541939052875 no 2571 0.125889386368654 966 13791 A steroid.
SGTC_1471 k673-0312 37 µM -1.14630939047327 0.250488189698028 no 2572 0.125833579406516 964 24099884
SGTC_1137 ixabepilone 100 µM -1.14871250478954 0.250009719566493 no 2573 0.125337273907543 959 154225 A novel microtubule stabilizer.
SGTC_2618 avocadyne 43.43 µM -1.14881341168033 0.249989639196283 no 2574 0.125316463951708 969 3015189
SGTC_382 3229-0966 23.2 µM -1.14915003926353 0.249922656834721 no 2575 0.125247058932311 979 5722370
SGTC_1158 4092-0494 91.8 µM -1.14942005129634 0.249868936561212 no 2576 0.125191407938594 964 1148199
SGTC_146 3448-8650 53.125 µM -1.15034746538345 0.249684469481959 no 2577 0.125000394208413 986 2891488 YIL048W NEO1
SGTC_1955 wogonin 32.4 µM -1.15130813422128 0.249493464164973 no 2578 0.124802745962534 952 5281703 A flavanone.
SGTC_2774 tamoxifen 10.92 µM -1.15194733032578 0.249366418807038 no 2579 0.124671358648653 958 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.
SGTC_2798 7813637 45.45 µM -1.1537952949639 0.248999314510031 no 2580 0.124292051802237 956 956368
SGTC_338 4055-0136 114 µM -1.15398628368876 0.248961390370049 no 2581 0.124252896185291 973 2900563
SGTC_1830 st055982 50.3 µM -1.15401455158595 0.248955777547548 no 2582 0.124247101566044 977 455313 An antimicrobial agent.
SGTC_1734 st037168 69.4 µM -1.15685711300031 0.248391707725918 no 2583 0.123665371562028 979 708907
SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM -1.15713141143005 0.248337312785265 no 2584 0.12360933747067 969 368090
SGTC_1242 0402-0103 60.1 µM -1.159946124193 0.247779506313477 no 2585 0.123035370966886 961 432868
SGTC_1397 3532-0190 20.1 µM -1.161842068853 0.247404154352895 no 2586 0.122649811106108 945 5322280
SGTC_1040 k898-0338 155 µM -1.16353767656975 0.24706872194449 no 2587 0.122305710481016 972 20969351
SGTC_2284 7945075 39.21 µM -1.16400458851861 0.246976398154201 no 2588 0.122211076129016 958 1245402
SGTC_792 4534-1957 155 µM -1.16546069298041 0.246688597186804 no 2589 0.121916281067555 964 1717904
SGTC_3337 9144342 33.5465 µM -1.16906421796987 0.245977128609178 no 2590 0.121188879525821 959 17682949
SGTC_1424 4048-1941 275 µM -1.16937603988783 0.24591561527515 no 2591 0.121126079476276 961 X1424
SGTC_2103 5378138 10 µM -1.17151759923064 0.245493371456443 no 2592 0.12069539395864 952 244142
SGTC_716 1683-5115 658 µM -1.17231795543305 0.245335668051309 no 2593 0.120534712687587 967 723597
SGTC_711 k292-0785 179 µM -1.17251578406342 0.245296695991502 no 2594 0.120495019405281 952 4146315
SGTC_369 0957-0393 4.5 µM -1.17264277801147 0.245271680053482 no 2595 0.120469543584082 976 6997992
SGTC_668 1682-0499 62.6 µM -1.17995688738467 0.243833225124762 no 2596 0.119008681182451 982 682214
SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM -1.18295272602755 0.243245355076007 no 2597 0.118413941756319 990 6708784 An antioxidant flavonoid
SGTC_83 0170-0301 39.027 µM -1.18529766122889 0.242785746156381 no 2598 0.117949888942029 992 3089716
SGTC_2137 5261020 140 µM -1.18582153602644 0.242683130603652 no 2599 0.117846392378423 952 763655
SGTC_2522 biochanin a 4.94 µM -1.18782807908162 0.242290310234589 no 2600 0.117450574730266 972 5280373 A possible chelator.
SGTC_2118 5526350 200 µM -1.18855656463699 0.24214778013267 no 2601 0.117307104325327 973 743594
SGTC_2899 9053889 58.44 µM -1.18966345927299 0.241931300342863 no 2602 0.117089346418605 954 6470052
SGTC_377 3970-0964 33.1 µM -1.19146364473292 0.241579455237035 no 2603 0.116735810280569 977 16481235
SGTC_3155 9099265 49.47 µM -1.19169975108158 0.241533329020024 no 2604 0.116689497853429 980 25236499
SGTC_3034 9090421 49.47 µM -1.19170219275279 0.241532852035151 no 2605 0.116689018985963 954 17173761
SGTC_117 lucigenin 22.078 µM -1.19207128846102 0.241460754406766 no 2606 0.116616646916051 1001 65100 An acridine derivative; a dye stuff and potential carcinogen.
SGTC_1318 1280-3875 124 µM -1.19412321036338 0.241060153684956 no 2607 0.116214887611621 981 373245
SGTC_18 0111-0177 500 nM -1.1961252876598 0.240669632806281 no 2608 0.115823835385474 982 721752
SGTC_1558 st069300 45.6 µM -1.19777691629484 0.240347729081293 no 2609 0.115501938044671 960 24208000
SGTC_3054 9094397 49.47 µM -1.19886821607274 0.24013516265255 no 2610 0.115289596142069 981 2598354
SGTC_1159 4092-0538 61.2 µM -1.19895877802892 0.240117527346876 no 2611 0.115271987339985 992 717301
SGTC_2077 5212015 200 µM -1.19967487238554 0.239978105766378 no 2612 0.115132817787224 955 780900
SGTC_938 3126-1755 342 µM -1.20026724090758 0.239862806632957 no 2613 0.115017784084855 951 1777771
SGTC_271 rotenone 740 µM -1.20091617812724 0.23973653160971 no 2614 0.114891858992365 988 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria.
SGTC_1590 st077108 57.8 µM -1.20368768409635 0.23919763990193 no 2615 0.11435515712141 960 5489485
SGTC_124 0136-0217 7.121 µM -1.20587309003539 0.23877317669956 no 2616 0.113933213991862 972 3976905
SGTC_560 2332-1943 155 µM -1.20646959328903 0.238657391734044 no 2617 0.113818238209632 959 21177716
SGTC_1737 st035557 69.7 µM -1.20879228138401 0.238206836507213 no 2618 0.113371328856343 959 5716916
SGTC_2190 6049624 200 µM -1.21058367501796 0.237859660384317 no 2619 0.113027502005938 950 2265554
SGTC_2885 9057732 51.95 µM -1.2111137611195 0.237756981730236 no 2620 0.112925904030077 971 6471414
SGTC_763 3453-1109 128 µM -1.21121948160206 0.237736506386476 no 2621 0.112905649108013 974 1560353
SGTC_2588 indole-3-carbinol 100 µM -1.21307580570595 0.237377141705325 no 2622 0.112550419592832 973 3712 Induces cell cycle arrest.
SGTC_2100 5377183 190 µM -1.21480579934459 0.237042501952474 no 2623 0.112220084226428 954 2844202
SGTC_2058 5236698 133 µM -1.21684954850652 0.23664750545931 no 2624 0.111830732035846 960 766665
SGTC_2877 9040724 71.43 µM -1.21838715093196 0.236350571064921 no 2625 0.111538442782037 980 6463895
SGTC_1596 piperlongumine 63 µM -1.21849529779135 0.236329693986806 no 2626 0.111517905290507 961 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_350 k064-0020 19.8 µM -1.21884245172836 0.236262684941097 no 2627 0.111451997749885 932 2790705
SGTC_2454 5-benzylidenerhodanine 10.36 µM -1.21925580041789 0.236182912366088 no 2628 0.111373559428142 982 1273210
SGTC_1852 st056254 31.4 µM -1.22418474249484 0.235232815018681 no 2629 0.110441271773159 972 442583
SGTC_1950 st077106 7.18 µM -1.22468581985155 0.235136346224128 no 2630 0.110346809447296 960 13831864
SGTC_1080 nisoldipine 24.4 µM -1.22655181318783 0.234777292303327 no 2631 0.109995544909611 986 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class.
SGTC_3209 9113616 49.47 µM -1.22873836268348 0.234356943006191 no 2632 0.109584958935552 984 16649353
SGTC_1666 st014829 29 µM -1.22894987678723 0.234316302961081 no 2633 0.109545299685515 992 3858230
SGTC_3186 9110464 49.47 µM -1.23157941044238 0.233811393584098 no 2634 0.109053118033333 983 17018021
SGTC_411 enrofloxacin 100 µM -1.23272222605414 0.233592144188191 no 2635 0.10883970828758 971 71188 A bacterial gyrase inhibitor.
SGTC_1269 0831-0796 3.05 µM -1.2329382946411 0.233550704206715 no 2636 0.108799393347094 946 927758
SGTC_1372 2752-0194 270 µM -1.23364467734249 0.233415254912479 no 2637 0.108667668574003 974 823334
SGTC_2063 5246145 200 µM -1.23470564366398 0.233211895911492 no 2638 0.108470037362891 983 711240
SGTC_3269 9137823 49.47 µM -1.23764488521319 0.232649035473918 no 2639 0.107923881791039 941 17682936
SGTC_1989 st071868 50.2 µM -1.237917226656 0.232596920740651 no 2640 0.107873377056724 964 16414057
SGTC_2701 st077767 14.721 µM -1.24167756470177 0.231878013531585 no 2641 0.107177775423644 980 5721188
SGTC_5 0352-0601 109.883 µM -1.24191003285382 0.231833610568608 no 2642 0.107134878985999 973 762456
SGTC_542 3381-0244 89.3 µM -1.24270271390886 0.231682238831312 no 2643 0.106988701745914 995 1112843
SGTC_3205 9113483 49.47 µM -1.2430223948739 0.231621207592693 no 2644 0.106929790540412 973 17018033
SGTC_2061 5245884 80.95 µM -1.2432342056735 0.231580775102167 no 2645 0.106890770674304 992 573863
SGTC_992 3909-8734 162 µM -1.24374401589181 0.23148347373719 no 2646 0.10679689536322 1003 4288319
SGTC_1928 4'-methoxychalcone 40.3 µM -1.24663794337813 0.230931576621151 no 2647 0.106265141232969 978 641818
SGTC_1225 1216-0074 20.6 µM -1.24667531845414 0.230924453677929 no 2648 0.10625828615865 985 4241466
SGTC_464 bw-b 70c 158 µM -1.24805919264003 0.230660801263032 no 2649 0.106004690475041 989 5353454
SGTC_1611 st001856 99.4 µM -1.24961950537808 0.230363736012004 no 2650 0.105719287189508 1006 647478
SGTC_621 3584-0052 32.1 µM -1.25024170877923 0.230245335465317 no 2651 0.10560563244849 974 2273927
SGTC_2394 5221648 200 µM -1.25158410631891 0.229990003451064 no 2652 0.105360724489834 984 788586
SGTC_1983 st071813 46.9 µM -1.25170173529233 0.229967637272981 no 2653 0.10533928377141 992 11838595
SGTC_283 0987-0079 11.7 µM -1.25211378354646 0.229889299301483 no 2654 0.105264202930193 987 411556
SGTC_1978 st071761 42 µM -1.25299105563359 0.229722563470838 no 2655 0.105104480915669 967 5147680
SGTC_680 0417-1641 114 µM -1.25348847110295 0.229628053932834 no 2656 0.105013996091151 984 2835990
SGTC_1119 parthenolide 318.541 nM -1.25428938072693 0.229475925918792 no 2657 0.104868421170225 1005 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs.
SGTC_1169 aniline yellow 25.8 µM -1.2550211954931 0.229336971455558 no 2658 0.104735532865155 978 6051 A DNA damaging agent.
SGTC_1183 1254-0324 198 µM -1.25666292855305 0.229025416511808 no 2659 0.104437858666308 977 5799357
SGTC_3343 9148379 18.9835 µM -1.25823255019109 0.228727768465203 no 2660 0.104153833175003 947 1955036
SGTC_1212 0520-0165 585 µM -1.26723290779935 0.227025226190263 no 2661 0.102536011156409 1007 5403258
SGTC_1125 tnp00248 1.32998 µM -1.2695144728842 0.22659477464616 no 2662 0.102128815981048 976 24207736
SGTC_861 0443-0273 110 µM -1.27135775802518 0.226247347913249 no 2663 0.101800701605557 983 6149169
SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM -1.27145314069455 0.226229378155869 no 2664 0.101783743897927 965 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_3222 9128301 49.47 µM -1.27386313105209 0.225775612169491 no 2665 0.101355963370871 959 4911358
SGTC_3183 9108214 49.47 µM -1.27400101367883 0.225749666463515 no 2666 0.101331528462102 976 4974831
SGTC_296 1222-0039 74.9 µM -1.27537346702674 0.225491500576693 no 2667 0.101088542683419 993 5984176
SGTC_2203 7227154 166.4 µM -1.27539858909935 0.225486776537147 no 2668 0.101084098911473 992 896304
SGTC_2547 epiafzelechin trimethyl ether 100 µM -1.27787029186203 0.225022263164939 no 2669 0.100647582291753 953 6708630 An antioxidant.
SGTC_2865 9030313 51.95 µM -1.27932260556399 0.224749579287152 no 2670 0.100391737672673 992 42562754
SGTC_2340 7987427 183.45 µM -1.2816789980499 0.224307546079976 no 2671 0.0999776376340097 982 2239331
SGTC_2916 7875993 68.79 µM -1.28453947869556 0.223771615321689 no 2672 0.099476629680624 969 1299250
SGTC_378 3970-0959 8.33 µM -1.28622630297433 0.223455918658751 no 2673 0.0991820469533339 1010 6615653
SGTC_892 0929-0076 29 µM -1.28815877828826 0.223094558926506 no 2674 0.0988453489968519 976 5751038
SGTC_1150 3909-7983 10.9 µM -1.28938273162886 0.222865860200816 no 2675 0.0986325308946577 996 23965914
SGTC_2570 licareol 100 µM -1.29003469504813 0.222744093758608 no 2676 0.0985193060462182 989 443158
SGTC_3098 9119039 49.47 µM -1.2909152192531 0.222579699485481 no 2677 0.0983665387080636 979 17161528
SGTC_1585 2',4'-dihydroxychalcone 10.4 µM -1.29221070755424 0.222337957025953 no 2678 0.0981420922827039 987 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_974 1326-0144 138 µM -1.29411209769663 0.221983422637652 no 2679 0.0978133517080058 1002 5411856
SGTC_1618 st003135 44.5 µM -1.29606904164113 0.221618866956718 no 2680 0.0974758498193081 1013 1270615
SGTC_13 0199-0087 65 µM -1.29633912476797 0.22156858052356 no 2681 0.0974293374285511 994 4589825
SGTC_1887 st057648 70.8 µM -1.29808938287694 0.221242860309308 no 2682 0.097128311112199 993 688672
SGTC_223 busulfan 5 mM -1.29866267134939 0.221136231826676 no 2683 0.0970298599751382 980 2478 A DNA alkylator.
SGTC_1713 st033146 12.748 µM -1.29877347120143 0.221115627058539 no 2684 0.0970108407067346 1007 674619
SGTC_1827 berberine 7.24 µM -1.30296453931623 0.220337046903808 no 2685 0.0962934340891528 954 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_2415 st077333 57.7 µM -1.30330353316024 0.220274140354008 no 2686 0.0962355776786567 969 2766255
SGTC_2800 7887935 81.82 µM -1.3045056887646 0.220051141272813 no 2687 0.0960306105838795 1019 2961002
SGTC_2639 lactacystin 53 µM -1.31211319640704 0.218642959972126 no 2688 0.0947409720258562 966 3870 A proteasome inhibitor.
SGTC_2353 9059630 146.67 µM -1.31355124481363 0.218377355396604 no 2689 0.0944986325563975 1007 4779114
SGTC_2964 9083345 53.42 µM -1.31368449715278 0.218352753376434 no 2690 0.0944762000714466 968 17741579
SGTC_2271 7849410 118.62 µM -1.31536513440373 0.218042598935491 no 2691 0.0941936086473545 1007 972430
SGTC_2331 7980721 200 µM -1.31713675803674 0.217715928478243 no 2692 0.0938963938806292 973 2981221
SGTC_1472 k841-0093 193 µM -1.31878904128805 0.217411517874502 no 2693 0.0936198244631611 1009 X1472
SGTC_1004 4084-0029 199 µM -1.32140399075138 0.216930251735306 no 2694 0.0931833480562505 1001 716894 YLR208W SEC13
SGTC_593 1203-0218 61.7 µM -1.32155096655043 0.216903219990717 no 2695 0.093158860182525 1008 3666956
SGTC_11 0438-0307 1.3 µM -1.32227318311282 0.216770418433838 no 2696 0.0930385996182073 1000 4011476
SGTC_1939 st074455 53.6 µM -1.32394451941272 0.216463272610638 no 2697 0.0927607356132959 1002 1644229
SGTC_2207 7258803 200 µM -1.32454238033111 0.216353463338792 no 2698 0.0926614888537413 996 3666799
SGTC_2675 theaflavin digallate 100 µM -1.325578604104 0.216163216239184 no 2699 0.0924896585741513 1014 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative.
SGTC_2260 7964312 200 µM -1.32923534512678 0.21549262587891 no 2700 0.0918851687405706 1011 231951
SGTC_2658 polymyxin b sulfate 77.05 µM -1.33231686962582 0.214928459452406 no 2701 0.0913780430067301 1006 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides. YIL048W NEO1
SGTC_3089 9117425 49.47 µM -1.33620345607314 0.214218126787858 no 2702 0.090741390877657 1011 9401657
SGTC_20 0481-0013 4.944 µM -1.33662611830538 0.214140961277784 no 2703 0.090672354568514 985 182045
SGTC_958 1222-0007 33 µM -1.33708741506279 0.214056760719162 no 2704 0.0905970523175407 992 7312461
SGTC_2592 piperlongumine 83.33 µM -1.33822148001096 0.213849841627621 no 2705 0.0904121245034634 1009 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_1972 st070201 17.4 µM -1.3389384530193 0.213719084364679 no 2706 0.0902953550491404 1011 2829099
SGTC_53 0973-0023 39.979 µM -1.34433345225584 0.212736671242904 no 2707 0.0894202913712391 990 674768
SGTC_2814 7977482 42.97 µM -1.34483169927959 0.212646075143189 no 2708 0.0893397954665842 996 6456762
SGTC_2608 thymoquinone 42.66 µM -1.34532080229067 0.212557163613799 no 2709 0.0892608292961386 1003 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC).
SGTC_3319 9138450 16.7555 µM -1.34811547532991 0.212049550982861 no 2710 0.0888106223951699 971 2029690
SGTC_2116 5511452 16.8835 µM -1.34841106561448 0.211995902695975 no 2711 0.0887631034314174 997 870744
SGTC_1717 st033143 58.0435 µM -1.35006828955836 0.211695271164982 no 2712 0.0884970394356633 1001 674616
SGTC_1115 galangin 695.678 nM -1.35264431823597 0.211228458003233 no 2713 0.08808464346363 1016 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_1383 3049-0032 20.7 µM -1.35346651710798 0.211079590900362 no 2714 0.0879533198892522 994 712864
SGTC_937 3122-0005 46.7 µM -1.35435162789441 0.210919401735712 no 2715 0.0878121111204311 987 759535
SGTC_43 0570-0105 72.5 µM -1.35727802210581 0.210390284594023 no 2716 0.0873464439531546 992 1114046 YDL195W SEC31
SGTC_2999 9069765 71.4286 µM -1.36113116899184 0.209694792454085 no 2717 0.0867361206077507 991 2097066
SGTC_2591 skatole 100 µM -1.36258898619645 0.209432009692114 no 2718 0.0865060409383496 1003 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite.
SGTC_3244 9134489 49.47 µM -1.36292881820721 0.209370780218839 no 2719 0.0864524726655378 1015 16584271
SGTC_2444 5485484 36.41 µM -1.36363067458283 0.209244356099146 no 2720 0.0863419164155722 1024 6790631
SGTC_2537 larixol 68.93 µM -1.36623341525809 0.208775921592106 no 2721 0.0859328562532067 995 6708759
SGTC_1630 st005209 31.3 µM -1.36771733190523 0.208509126957445 no 2722 0.0857002863206574 980 3367314
SGTC_600 1495-0418 41.6 µM -1.36800047871555 0.208458242600803 no 2723 0.0856559631311713 1006 5377768
SGTC_2942 9052777 62.25 µM -1.36900505718353 0.208277768740601 no 2724 0.0854988470522712 1014 6469503
SGTC_939 1165-0479 45.3 µM -1.36923310165246 0.208236813089411 no 2725 0.0854632109728697 984 1377347
SGTC_1078 idebenone 36.1 µM -1.37098574493994 0.207922205712357 no 2726 0.085189699918151 1010 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen.
SGTC_1142 3253-1408 9.78 µM -1.37204579203218 0.207732058759554 no 2727 0.0850245914948191 1016 256655
SGTC_2568 diosmetin 100 µM -1.37653371251945 0.206928172560887 no 2728 0.0843282287001103 1003 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.
SGTC_1546 5-methoxyflavanone 78.7 µM -1.37659574024849 0.206917074931714 no 2729 0.0843186343176046 1002 147795
SGTC_765 1319-0117 244 µM -1.37703344541881 0.206838773361814 no 2730 0.0842509538368224 973 3487746 YGL099W LSG1
SGTC_2540 epiandrosterone 100 µM -1.37900231055939 0.206486777816781 no 2731 0.0839470207521628 1005 441302 A steroid.
SGTC_2643 anethole 100 µM -1.38065182697572 0.206192149116771 no 2732 0.0836930198948271 1027 637563 An anti-fungal, anti-helmenthic and channel blocker.
SGTC_2220 6782180 200 µM -1.38161455461094 0.206020306565156 no 2733 0.0835450413051705 991 833803
SGTC_50 0929-0078 56.389 µM -1.38991525557821 0.204542195302283 no 2734 0.0822773062488979 966 1377751
SGTC_2924 9010168 62.78 µM -1.39742626035511 0.20321015992924 no 2735 0.0811427134265767 1021 2993929
SGTC_2364 9055074 200 µM -1.40001628541665 0.202752036493931 no 2736 0.0807542208874059 1005 6470630
SGTC_3105 9121040 49.47 µM -1.40273354193008 0.202272072306625 no 2737 0.080348155599433 963 41448907
SGTC_932 2857-0803 154 µM -1.40329491256727 0.202172999051036 no 2738 0.0802644573235666 1012 674898
SGTC_3270 9137563 49.47 µM -1.40382518210837 0.202079441329054 no 2739 0.0801854566388046 979 17015724
SGTC_2167 5876490 200 µM -1.40573481730819 0.201742730945912 no 2740 0.0799014420235927 1000 686534
SGTC_3282 9108498 15.4605 µM -1.40575923153492 0.201738428361046 no 2741 0.0798978158965679 1012 16459645
SGTC_3284 9108171 64.8615 µM -1.40797169185489 0.201348748707522 no 2742 0.079569726246271 983 8687505
SGTC_31 0508-1974 57.237 µM -1.40941892491657 0.201094092459209 no 2743 0.0793556656583953 975 6810525
SGTC_2267 7931562 200 µM -1.40985962397155 0.201016585096352 no 2744 0.079290568411349 1019 934880
SGTC_1984 st072354 53.1 µM -1.41024979342605 0.200947979518155 no 2745 0.0792329688198421 993 5762938
SGTC_3328 9140624 29.0385 µM -1.41052360045198 0.200899842956248 no 2746 0.0791925663981609 1025 4904392
SGTC_753 1322-0200 289 µM -1.41059837144629 0.200886699066834 no 2747 0.0791815360504973 1018 5403907
SGTC_3178 9107506 49.47 µM -1.4124236120365 0.200566002618963 no 2748 0.0789126340367102 1002 8897194
SGTC_1061 3448-9325 110 µM -1.41332021639122 0.200408581071217 no 2749 0.0787807961989147 1005 723482
SGTC_1420 4'-methoxyflavone 42 µM -1.41585620890963 0.199963725529873 no 2750 0.0784088042561662 1006 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13
SGTC_1926 methyl fluorone black 53.6 µM -1.41809251575923 0.199571932947002 no 2751 0.0780818780221538 953 72721 Reacts with homocysteine.
SGTC_2752 diclazuril 33.15 µM -1.4200894481423 0.199222468626603 no 2752 0.0777908209124152 990 456389 An antifungal agent for coccidioides. YHR062C RPP1
SGTC_918 glabranin 770.725 nM -1.42049230518821 0.199152013113576 no 2753 0.0777322035956584 1028 124049 Also referred to as licorice root.
SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM -1.42081758271858 0.199095136405694 no 2754 0.0776848988796886 1010 7104
SGTC_189 3970-0742 2.116 µM -1.42150396759713 0.198975150050896 no 2755 0.0775851504782217 1008 2891807
SGTC_49 0717-0965 32.132 µM -1.42169105269903 0.19894245342285 no 2756 0.077557979339555 1024 5889349 YGL099W LSG1
SGTC_1755 st041960 45.185 µM -1.42405861611424 0.198528957178653 no 2757 0.0772147523795479 1016 2257073
SGTC_2488 5268135 45.7 µM -1.42563941447872 0.198253158743438 no 2758 0.0769862264895088 1007 1270356 YLR208W SEC13
SGTC_986 1493-0483 84 µM -1.42720983420957 0.197979400163765 no 2759 0.076759710355152 1011 40079
SGTC_3313 9133968 57.047 µM -1.42940561015403 0.197597011304614 no 2760 0.0764438434402175 990 1494643
SGTC_174 3553-0389 74.3 µM -1.43286577318709 0.196995339473921 no 2761 0.0759481001205951 1017 738071
SGTC_2711 st079103 59.1 µM -1.43439628219568 0.196729560419292 no 2762 0.0757296040015815 1005 54693780
SGTC_603 3794-0023 45.9 µM -1.43517743271124 0.196593994233954 no 2763 0.0756182713385728 1023 3802260
SGTC_1620 st003704 16.5 µM -1.4362442385866 0.196408944922053 no 2764 0.0754664274392393 1021 2834414
SGTC_2198 6589944 200 µM -1.4371045672371 0.196259788300327 no 2765 0.0753441418386151 999 5290268
SGTC_671 0560-0003 407 µM -1.44032285531841 0.195702437519947 no 2766 0.0748880390478735 1023 3238678
SGTC_1877 wortmannin 25 µM -1.44169012887433 0.195465940934739 no 2767 0.07469490478178 1017 312145 A covalent inhibitor of PI 3-kinase.
SGTC_2309 7664088 163.95 µM -1.44415392149732 0.195040218469904 no 2768 0.0743478415756979 994 704922
SGTC_1350 1495-0454 146 µM -1.44887991479741 0.194225186115234 no 2769 0.073685560582931 1013 1069057
SGTC_132 0417-1715 25.805 µM -1.44897173207342 0.194209372118082 no 2770 0.0736727384999416 1030 6769098
SGTC_1491 4138-0063 26.5 µM -1.44952695754779 0.194113760483819 no 2771 0.0735952388096134 1029 23883227
SGTC_2604 4'-hydroxychalcone 11.32 µM -1.45147781148597 0.193778044521379 no 2772 0.073323428201294 1023 5282362
SGTC_2883 9059145 45.46 µM -1.45221093847722 0.193651974692974 no 2773 0.073221481067526 1032 16476510
SGTC_264 promethazine 12.5 mM -1.45258501161505 0.19358766768215 no 2774 0.0731695050262191 1010 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3
SGTC_2910 7948405 25.97 µM -1.45332970117934 0.193459686681406 no 2775 0.0730661172856357 977 2971328
SGTC_1902 st060212 70.5 µM -1.45537975326791 0.193107635155165 no 2776 0.0727820792076345 990 688944
SGTC_1193 1488-0126 41.5 µM -1.45632862649865 0.192944819468409 no 2777 0.0726508978197984 1010 1384710
SGTC_1066 ketoconazole 628 nM -1.45641361048667 0.192930241289475 no 2778 0.0726391576542881 1013 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W
SGTC_2115 tiliquinol 12.7705 µM -1.45651083359751 0.192913564432778 no 2779 0.0726257284895594 1012 71208 A bioactive hydroxyquinoline.
SGTC_1476 4112-3294 3.34 µM -1.45751097838568 0.19274205890216 no 2780 0.0724876915703096 967 704369
SGTC_989 1501-0895 10.3 µM -1.45778551927633 0.192694996738864 no 2781 0.0724498354572016 1000 2830112
SGTC_290 2043-6722 48.1 µM -1.45990224159075 0.192332381221928 no 2782 0.0721584715468756 1019 773758 YLR208W SEC13
SGTC_3094 9117742 49.47 µM -1.46075578379633 0.192186279122817 no 2783 0.0720412370612817 1018 17149698
SGTC_62 0180-0423 3.232 µM -1.46147398362338 0.192063396396171 no 2784 0.0719427050995169 1014 30102 YGL099W LSG1
SGTC_1563 conessine 56.1 µM -1.46217023984964 0.19194431408978 no 2785 0.0718472823246393 1031 441082 An anti-amoebic, histamine inhibitor.
SGTC_1081 sertraline 6 µM -1.46306308820036 0.191791674328774 no 2786 0.0717250584381442 1010 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1
SGTC_961 1252-1571 372 µM -1.4632988997105 0.191751372823667 no 2787 0.0716928043448531 1020 6813498
SGTC_507 nimesulide 162 µM -1.46634266281682 0.191231642254163 no 2788 0.0712774791392779 1019 4495 A COX2 inhibitor.
SGTC_1264 0783-0040 158 µM -1.46660018748404 0.191187708897177 no 2789 0.0712424245072319 1002 2855798
SGTC_1847 st056231 15 µM -1.4674701839503 0.191039334456355 no 2790 0.0711240972047054 999 5393180
SGTC_214 4373-3496 70 µM -1.47238791241667 0.19020196388732 no 2791 0.0704580777095713 1026 3779166
SGTC_1184 1269-1718 139 µM -1.4735751230965 0.190000148961496 no 2792 0.0702980117259521 1006 5403821
SGTC_1715 st032160 10.2275 µM -1.47381558307108 0.189959289006649 no 2793 0.0702656257294508 1009 5289825
SGTC_2102 5377816 72.7585 µM -1.47393780101211 0.189938523298493 no 2794 0.070249169385247 1008 1379702
SGTC_334 1502-1024 68.5 µM -1.47500968848869 0.189756461693747 no 2795 0.0701049693482721 1028 3296216
SGTC_615 k087-0205 167 µM -1.47561134261363 0.189654316932742 no 2796 0.0700241292051638 1021 9642773
SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM -1.47862643143732 0.189142945197079 no 2797 0.0696200922364121 1028 521171
SGTC_1501 4491-0275 38.4 µM -1.4787822367093 0.189116543061022 no 2798 0.06959926242534 1029 5104718
SGTC_1379 2144-0755 36.5 µM -1.47990145273379 0.188926951923727 no 2799 0.0694497739767179 1010 5392327
SGTC_1512 0259-0544 12.2 µM -1.48086530351549 0.188763772976205 no 2800 0.0693212352117604 1001 18476
SGTC_2807 7945238 51.95 µM -1.48113247293537 0.188718556848255 no 2801 0.0692856380607998 1032 17148797
SGTC_3217 9129673 49.47 µM -1.48450652854606 0.18814810161088 no 2802 0.0688372962353906 1028 17248312
SGTC_3044 9093193 49.47 µM -1.48471241366438 0.188113326874209 no 2803 0.0688100109608308 1018 25236277
SGTC_1606 st000094 49.2 µM -1.48720376104908 0.187692843826545 no 2804 0.0684805015145723 1009 1242210
SGTC_1654 st012436 41.8 µM -1.48749919349438 0.187643020053144 no 2805 0.0684415080342106 1043 4323132
SGTC_2771 fluoxetine 41.05 µM -1.49067060050183 0.187108686798648 no 2806 0.0680239992095159 1017 3386 A selective serotonin reuptake inhibitor.
SGTC_2831 7999036 19.48 µM -1.49246188594015 0.186807299108691 no 2807 0.0677890509154551 1025 2988270
SGTC_1494 4358-1428 177 µM -1.4931635919632 0.186689317487083 no 2808 0.0676971849055895 1009 1564571
SGTC_1934 st074720 32.6 µM -1.49467595827311 0.186435192070196 no 2809 0.0674995158426998 1005 17250992
SGTC_2572 astragaloside iv 100 µM -1.49676299880877 0.18608485524725 no 2810 0.0672274686260362 1014 45006101 An anti-inflammatory agent.
SGTC_101 0490-5701 117.494 µM -1.49824709408904 0.185835979047206 no 2811 0.0670345320476599 1002 4661669
SGTC_380 3970-0968 6 µM -1.499107772589 0.185691741699242 no 2812 0.0669228377658591 1026 2891601
SGTC_629 3448-6466 76.7 µM -1.50204359450506 0.185200262855236 no 2813 0.0665429252678151 1033 573744
SGTC_1361 1608-0041 5.61 µM -1.50382438303931 0.184902539367668 no 2814 0.0663132955962193 1016 X1361
SGTC_2245 6637752 200 µM -1.50508497919572 0.184691964832399 no 2815 0.0661511151412683 1033 681890
SGTC_3043 9092303 49.47 µM -1.50545700012121 0.184629849617266 no 2816 0.06610331200728 1016 25236084
SGTC_318 1488-0629 67.2 µM -1.50568077273968 0.184592493233516 no 2817 0.0660745710532957 1034 3662576
SGTC_187 1488-2104 32.728 µM -1.50572483090031 0.184585138760787 no 2818 0.0660689134429833 1025 2852859
SGTC_2065 5221596 34.26 µM -1.50699821024312 0.184372656801224 no 2819 0.0659055579797257 1003 788581
SGTC_3199 9111318 49.47 µM -1.50781420955531 0.184236575421774 no 2820 0.0658010421779306 1007 8548020
SGTC_664 1222-0054 14.9 µM -1.50849267490723 0.184123477708388 no 2821 0.0657142400183908 1027 6813991
SGTC_1234 0326-0494 15.5 µM -1.50869763633449 0.184089319883514 no 2822 0.0656880349301657 1017 1547813
SGTC_8 0354-0001 70 µM -1.51074614181004 0.18374814319432 no 2823 0.065426570730795 1033 4993152
SGTC_2854 9024559 71.43 µM -1.51085698847261 0.183729693026442 no 2824 0.0654124456978302 1012 3163529
SGTC_1112 tnp00069 1.16933 µM -1.51389938699183 0.183223743549053 no 2825 0.0650256798205069 1018 145826
SGTC_1238 0333-0287 48.8 µM -1.51484756395761 0.183066239926142 no 2826 0.0649055060045317 1015 7226
SGTC_425 3825-7017 13.1 µM -1.51554539704943 0.182950375415085 no 2827 0.0648171714593266 1021 3397440
SGTC_3246 9135460 32.98 µM -1.51605589382507 0.182865644223455 no 2828 0.0647526098465931 1021 41446951
SGTC_610 4215-0184 155 µM -1.51683543551239 0.182736304782905 no 2829 0.0646541189681368 976 5605015
SGTC_1376 2910-0861 41.3 µM -1.51711262888642 0.18269032737897 no 2830 0.0646191251392783 1032 1112859
SGTC_584 0986-0246 15.4 µM -1.51929832296431 0.182328044572673 no 2831 0.0643437108402601 1038 53315 YDR232W HEM1
SGTC_2014 4013930 200 µM -1.52201916464598 0.18187768777625 no 2832 0.0640021393779174 1026 64556
SGTC_2625 euphol 100 µM -1.52242174955723 0.181811110603197 no 2833 0.0639517192756574 1016 6708538 A triterpene alcohol.
SGTC_617 3770-0098 35 µM -1.52261043806881 0.18177991163197 no 2834 0.0639280983875614 1018 5962639
SGTC_704 1310-0270 142 µM -1.52291501510588 0.181729557973943 no 2835 0.0638899843611522 1021 5718033
SGTC_2404 5161160 200 µM -1.52330061959175 0.181665821115708 no 2836 0.0638417561106441 1006 2831543
SGTC_1222 0366-0074 1.18 µM -1.52427618301945 0.181504631964152 no 2837 0.0637198670670834 1033 286520
SGTC_1699 st031318 29.054 µM -1.52748610437198 0.180974899301829 no 2838 0.0633200899758836 1022 5340658
SGTC_1850 st056238 17 µM -1.5278591671289 0.180913395734947 no 2839 0.0632737541106592 1004 5393177
SGTC_3073 9114972 49.47 µM -1.52970728995833 0.18060890524259 no 2840 0.0630445991879279 1024 41905075
SGTC_178 4092-0806 87.505 µM -1.53110496973533 0.180378841794425 no 2841 0.0628717258883989 987 2169044
SGTC_2876 9059903 25.97 µM -1.53341340437733 0.179999267438759 no 2842 0.0625870140465477 1023 6916095
SGTC_1726 st035556 14.5795 µM -1.53368801668129 0.179954146526928 no 2843 0.0625532116102628 1004 5919439
SGTC_845 0330-0138 4.51 µM -1.53422335440388 0.179866206846874 no 2844 0.062487357011331 1023 9039800
SGTC_2946 9065502 71.43 µM -1.5374384900671 0.179338626005869 no 2845 0.0620929834544909 975 16489101
SGTC_2689 tacrolimus 100 µM -1.53763174413046 0.179306945423724 no 2846 0.0620693406205493 997 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12).
SGTC_2434 5670830 169.91 µM -1.53975178626662 0.178959633146616 no 2847 0.0618104341725586 1038 1549830
SGTC_476 mead acid 10 µM -1.54192908859991 0.178603381280988 no 2848 0.0615454131802466 1045 5312531 An omega 9 fatty acid.
SGTC_1011 4112-3381 17.4 µM -1.54388460459033 0.178283799233119 no 2849 0.0613081451836878 1014 2877139
SGTC_1605 st000082 49.1 µM -1.54393552051939 0.178275483065699 no 2850 0.0613019769769769 994 1114022
SGTC_77 0828-0286 12.516 µM -1.54496564768707 0.178107283512446 no 2851 0.0611772864027739 1013 745345
SGTC_522 1273-0010 11.6 µM -1.54549080880648 0.17802157352004 no 2852 0.0611137951938813 1005 5705015
SGTC_2881 9058953 51.95 µM -1.54622289159213 0.177902135858198 no 2853 0.0610253734067621 1002 17122249
SGTC_2970 9090938 41.86 µM -1.54681804297065 0.17780507549954 no 2854 0.0609535640704123 1011 17217104
SGTC_2472 5377652 49.4 µM -1.54805081735868 0.177604134569165 no 2855 0.0608050310333028 1045 1610903
SGTC_1671 st016596 74.5 µM -1.54865827144915 0.177505172916907 no 2856 0.0607319450068556 1050 2829167
SGTC_3254 9136651 49.47 µM -1.55065724168064 0.177179762158986 no 2857 0.0604919232526938 1047 16454030
SGTC_1146 3579-1023 7 µM -1.55129279065537 0.177076380645917 no 2858 0.060415766870046 1035 X1146
SGTC_2555 cholic acid 100 µM -1.55194802160031 0.176969837472809 no 2859 0.060337330610802 1022 6708657 Influences liver metabolism.
SGTC_133 0724-0033 378.92 µM -1.55230586589765 0.176911667664354 no 2860 0.0602945275156021 1032 280309
SGTC_3259 9138485 49.47 µM -1.5544203881342 0.176568185674955 no 2861 0.0600420865552675 1018 17646153
SGTC_1667 st014849 34.6 µM -1.55449783197357 0.176555613745841 no 2862 0.0600328567040858 1023 5348460
SGTC_2678 equilin 100 µM -1.55454570279536 0.176547842867536 no 2863 0.0600271519568612 1002 3247 Equilin is an estrone commonly used hormone replacement therapy
SGTC_2886 9058944 51.95 µM -1.5573771206622 0.176088603155256 no 2864 0.0596904874646844 1017 4949929
SGTC_714 4296-0578 26.1 µM -1.55872133692787 0.175870843975082 no 2865 0.0595311747077844 1035 1589775
SGTC_1980 st071811 45.7 µM -1.55947319304628 0.175749119848149 no 2866 0.0594422122610927 1031 4974850
SGTC_176 1486-1328 72.834 µM -1.56180910548667 0.175371280501772 no 2867 0.0591664830526326 1014 22310231
SGTC_100 0086-0128 49.5915 µM -1.56220257547742 0.175307686520137 no 2868 0.0591201370448741 1029 93297
SGTC_291 SEC14.278 35.5 µM -1.56391997357306 0.175030285921803 no 2869 0.0589181816088013 1030 1068044
SGTC_489 paxilline 115 µM -1.56781471344123 0.174402225456945 no 2870 0.0584621900555675 1031 105008 A toxic potassium channel blocker.
SGTC_1303 1160-0052 261 µM -1.57057934033841 0.173957275398117 no 2871 0.0581401959482773 1016 3562476
SGTC_135 0933-0004 26.348 µM -1.57085956638186 0.173912215027458 no 2872 0.0581076361532293 1010 21230617 YGL099W LSG1
SGTC_2920 7982904 15.77 µM -1.57207700417229 0.173716537110657 no 2873 0.0579663469284216 1039 6456808
SGTC_3165 9101544 49.47 µM -1.57293594751393 0.173578564056016 no 2874 0.057866825183215 1039 5002184
SGTC_1680 diphenhydramine 100 µM -1.5745453885761 0.173320225492248 no 2875 0.0576807084616125 1008 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1
SGTC_2629 bisabolol 100 µM -1.57516543597016 0.173220764273648 no 2876 0.0576091315453893 1039 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer.
SGTC_1365 1672-3266 55.4 µM -1.57871749927827 0.172651681862204 no 2877 0.0572004345743134 1006 6415873
SGTC_2162 5663267 200 µM -1.57978005452528 0.17248167986018 no 2878 0.0570786224267446 1029 6456493
SGTC_191 3914-0123 66.505 µM -1.58122558855627 0.172250575191195 no 2879 0.056913233287532 1049 3144412
SGTC_1753 st043925 64 µM -1.58218800621479 0.172096818340151 no 2880 0.0568033287837588 1048 670181
SGTC_2793 7325131 81.82 µM -1.58268367696004 0.17201766365148 no 2881 0.0567467902865843 1017 4176441
SGTC_159 3970-0959 50 µM -1.58421554414275 0.171773183536669 no 2882 0.0565723385833944 1009 6615653
SGTC_872 0588-0139 234 µM -1.58586590459404 0.171510040818644 no 2883 0.0563848658172117 1036 2047100
SGTC_519 k048-0011 62.8 µM -1.590804025421 0.170724218679069 no 2884 0.0558268433798433 1020 6836379
SGTC_1405 3909-7894 12 µM -1.59384509886109 0.170241429430042 no 2885 0.0554853667850289 989 7104060
SGTC_278 4092-0821 23.9 µM -1.59418462438007 0.170187581983937 no 2886 0.0554473446346281 1044 877900
SGTC_987 1497-1013 404 µM -1.59587819650247 0.169919150943369 no 2887 0.0552579951731456 1033 1676435
SGTC_684 1140-0066 328 µM -1.59613032336056 0.169879212082562 no 2888 0.0552298499108581 1043 6813534
SGTC_2232 chlorophetanol 41.5365 µM -1.59750788428686 0.169661101981411 no 2889 0.0550762708123796 1051 15907 An antifungal of unknown mechanism. YFR051C RET2
SGTC_1249 0481-0015 10.2 µM -1.59797392232004 0.169587354563676 no 2890 0.0550243904299497 1012 4227577
SGTC_3068 9116768 49.47 µM -1.59900619150709 0.16942407807018 no 2891 0.0549096134366489 1035 41904888
SGTC_1555 citronellol 128 µM -1.60376225188584 0.168673104314236 no 2892 0.0543832340703209 1043 8842 A terpine precursor.
SGTC_649 1123-0311 367 µM -1.60655180633647 0.168233635429521 no 2893 0.0540763608801708 1030 693629 YIL048W NEO1
SGTC_33 0986-0033 35.816 µM -1.60733368726375 0.168110589494842 no 2894 0.0539905941240685 1003 2848082
SGTC_779 1360-0071 233 µM -1.60786138656208 0.168027577295204 no 2895 0.0539327701667908 1018 7566
SGTC_1508 1080-0625 72.9 µM -1.60877909728324 0.167883275372222 no 2896 0.0538323265297634 996 767111
SGTC_2151 5563267 85.4165 µM -1.61147566294638 0.167459725950298 no 2897 0.053538043754732 1051 5310824
SGTC_2844 9010103 25.97 µM -1.6127342088427 0.16726228207135 no 2898 0.0534011325338346 1028 2480525
SGTC_3018 9082602 49.47 µM -1.61578307663282 0.166784590273544 no 2899 0.0530706108751391 1005 17332089
SGTC_2093 5331342 194.4 µM -1.61616573304024 0.16672469849979 no 2900 0.0530292426814966 1035 33839
SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM -1.61622751184853 0.166715030441446 no 2901 0.0530225663003009 1056 91467 include heat shock
SGTC_2460 5552655 174.22 µM -1.61817847197683 0.166409901558446 no 2902 0.0528120704649599 1034 5401989
SGTC_14 0354-0009 295 µM -1.61889459425871 0.166297991029271 no 2903 0.0527349720914867 1054 1713507
SGTC_41 0478-0632 82.643 µM -1.62168953143599 0.16586168314534 no 2904 0.0524349207135233 1016 3750424
SGTC_75 0159-0059 199.013 µM -1.62522789901133 0.165310383246091 no 2905 0.0520570039447701 1040 5377270
SGTC_2861 9024595 19.48 µM -1.62599273697414 0.165191372718996 no 2906 0.0519756002182815 1035 16482810
SGTC_2027 5150920 200 µM -1.62638323340733 0.165130631975189 no 2907 0.0519340776692043 999 786715
SGTC_2166 5933061 31.504 µM -1.62880975875096 0.164753516118794 no 2908 0.0516766490930025 1050 2877375
SGTC_3194 9111903 49.47 µM -1.6311739438523 0.164386625837922 no 2909 0.0514268108175035 1044 17087251
SGTC_495 decylubiquinone 155 µM -1.63359258559812 0.164011833144904 no 2910 0.0511722128480646 1035 2971 A Co-enzyme Q analog. A free radical scavenger.
SGTC_775 4577-0580 57.3 µM -1.63406271793754 0.163939045846982 no 2911 0.0511228410529201 1039 2006902
SGTC_2683 piperine 63.03 µM -1.63818344771931 0.163301959270618 no 2912 0.0506917157213655 1051 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_1848 st056003 16.4 µM -1.64271044434521 0.16260391841495 no 2913 0.0502214284039707 1014 146492
SGTC_2550 chrysin dimethyl ether 71.87 µM -1.6427740115809 0.162594130497308 no 2914 0.0502148495627151 1009 88881 An O-methylated flavonoid and antioxidant.
SGTC_676 falcarinol 140 µM -1.64738976910414 0.161884432668337 no 2915 0.0497389784501159 1023 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer.
SGTC_2089 5281248 129.67 µM -1.64850365078041 0.161713470042706 no 2916 0.0496246810784215 1030 2737878
SGTC_1958 st076513 41.9 µM -1.65130949230997 0.161283340971599 no 2917 0.0493376975081121 1041 732122 YGL099W LSG1
SGTC_3040 9091894 49.47 µM -1.65202874577591 0.161173201343721 no 2918 0.049264345499666 1029 25236966
SGTC_2303 7774051 200 µM -1.65472723113933 0.160760418516416 no 2919 0.0489899203556071 1044 2953184
SGTC_959 1222-0044 107 µM -1.65560928253863 0.160625642407478 no 2920 0.048900484571288 1022 6083612
SGTC_1267 0828-0272 9.49 µM -1.66206780656157 0.159641039011588 no 2921 0.0482495898282041 1044 745334
SGTC_2882 9058044 58.44 µM -1.6623128366385 0.159603762052625 no 2922 0.0482250326524094 1030 18076804
SGTC_2913 7966556 36.57 µM -1.66245007147688 0.159582886706878 no 2923 0.0482112831996243 996 2976516
SGTC_2805 7950783 58.44 µM -1.66260170086725 0.159559823825746 no 2924 0.0481960952150048 1029 1178958 YDL195W SEC31
SGTC_1392 3455-1037 33.9 µM -1.66482141600085 0.159222454143957 no 2925 0.0479741949768154 1020 981132
SGTC_2644 guaiazulene 100 µM -1.66685611554909 0.15891361528315 no 2926 0.0477715094151113 1025 3515 A coloring agent.
SGTC_2950 9072895 21.46 µM -1.66829417262226 0.158695575325467 no 2927 0.0476286720870954 1026 17332245
SGTC_1813 st051246 8.6015 µM -1.66878249232825 0.158621580330375 no 2928 0.0475802468198701 1041 5291959
SGTC_1766 st045414 44.774 µM -1.67271164355946 0.158027020267758 no 2929 0.0471920379782401 1021 253960
SGTC_1764 st044502 93.5 µM -1.68076007615266 0.156813703287209 no 2930 0.0464047631270093 1037 8407
SGTC_1338 1486-1223 76 µM -1.68332215010226 0.156428755353931 no 2931 0.0461563723648376 1030 3444526
SGTC_2468 5987765 72.9 µM -1.68723554232457 0.155841975988653 no 2932 0.0457790348321121 1044 26772094
SGTC_3215 9129942 49.47 µM -1.68752285144441 0.155798953722158 no 2933 0.0457514298600176 1048 17682944
SGTC_155 k072-0202 43.6 µM -1.68891006125052 0.155591340228765 no 2934 0.0456183334319751 1043 5857737
SGTC_2954 9074818 52.69 µM -1.69142579183721 0.155215295099886 no 2935 0.045377754874499 1046 16648742
SGTC_1759 st043059 70 µM -1.69178976877422 0.155160938455746 no 2936 0.0453430325255471 1028 669426
SGTC_1351 1496-0003 46.5 µM -1.69202577315236 0.155125700065734 no 2937 0.0453205298126602 1055 3891978
SGTC_1673 st016611 27.3 µM -1.69413552134335 0.154810923161578 no 2938 0.045119766904086 1054 5226799
SGTC_1869 3',7'-dimethoxyflavone 40.3 µM -1.70104403167991 0.153783120422465 no 2939 0.0444673596452231 1044 688664
SGTC_2693 st077581 40.7 µM -1.70162832402313 0.153696400888985 no 2940 0.0444125322191795 1007 25238761
SGTC_2012 4023501 200 µM -1.70300749755675 0.153491835058672 no 2941 0.0442833326582997 1045 3477460
SGTC_457 grayanotoxin iii 135 µM -1.70349125776234 0.153420124094409 no 2942 0.0442380863263481 1021 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity.
SGTC_333 3486-0131 40.1 µM -1.70458809755108 0.153257614516456 no 2943 0.0441356363795469 1031 6744690
SGTC_1790 st045711 43.5 µM -1.70521484215753 0.153164806236748 no 2944 0.0440771814443735 1021 585119
SGTC_561 1550-0330 72.9 µM -1.70649899103431 0.15297476595993 no 2945 0.0439576070035418 1051 6812934
SGTC_3303 9125618 40.5795 µM -1.71038214168005 0.152401052711354 no 2946 0.0435976155780296 1028 22695467
SGTC_2722 naftopidil 47.16 µM -1.71138202768738 0.152253556784748 no 2947 0.0435053063538879 1038 4418 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_2094 5332512 191.667 µM -1.71213464792439 0.152142598244252 no 2948 0.0434359287589353 1048 755774
SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM -1.71439985771005 0.151808963242012 no 2949 0.0432276573260022 1045 115019
SGTC_2875 9039966 71.43 µM -1.71576814988711 0.151607667859306 no 2950 0.0431022428947533 1050 6463691
SGTC_1974 st069448 26.9 µM -1.71732818471084 0.151378380941252 no 2951 0.0429596125499856 1041 6323587 YNR016C ACC1
SGTC_2398 5228213 48.84 µM -1.71865353070899 0.151183768802881 no 2952 0.042838739097505 1045 80771 YMR134W ERG29
SGTC_1041 0206-0046 107 µM -1.71955582526901 0.151051372277029 no 2953 0.0427566059142158 1039 50494
SGTC_2338 7999974 200 µM -1.72023961289487 0.150951089367129 no 2954 0.0426944475864386 1026 315925
SGTC_1015 4130-4525 82 µM -1.72071897216295 0.150880813933034 no 2955 0.0426509159764077 1045 1363237
SGTC_3257 9139206 32.98 µM -1.72084819398387 0.150861873373273 no 2956 0.0426391872173144 1045 4910041
SGTC_2909 7941780 10.49 µM -1.72437141833227 0.15034607013821 no 2957 0.0423204069431939 1033 1243215
SGTC_599 1935-0052 86.5 µM -1.72582177742214 0.150134078095416 no 2958 0.0421897403541698 1053 9557311
SGTC_1402 3909-7673 35.9 µM -1.73108769231177 0.149366060312136 no 2959 0.0417180625870432 1051 5328014
SGTC_1940 st075990 51.1 µM -1.73138823157272 0.14932230682742 no 2960 0.0416912720847844 1052 1084979
SGTC_1492 4158-0558 28.5 µM -1.73302725786494 0.149083842634476 no 2961 0.0415454120529907 1024 3967268
SGTC_1482 3346-2049 8.48 µM -1.73721593797401 0.148475582038571 no 2962 0.041174531366769 1054 3826804
SGTC_404 fumagillin 50 µM -1.74316086841856 0.147615139923649 no 2963 0.0406527593601707 1035 12015870 A methionine aminopeptidase binder.
SGTC_3339 9145883 14.936 µM -1.74386501505303 0.147513446630897 no 2964 0.0405913151604085 1010 2030670
SGTC_2524 avocatin b 10.57 µM -1.74562684806612 0.147259207293694 no 2965 0.0404379069241155 1049 6710748
SGTC_2926 9010726 65.15 µM -1.74730486107571 0.147017336739491 no 2966 0.0402922351662617 1043 2994293
SGTC_1507 4075-3230 155 µM -1.74853926769818 0.146839578239123 no 2967 0.0401853461043907 1036 659771
SGTC_685 1278-0033 54.9 µM -1.75013744884235 0.146609649296926 no 2968 0.0400472995723677 1045 3590572
SGTC_3255 9139072 49.47 µM -1.75269748273208 0.146241843186458 no 2969 0.0398269740197457 1047 17646060
SGTC_2754 granisetron 64.02 µM -1.75279427548748 0.146227948911307 no 2970 0.039818663064448 1051 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients.
SGTC_3195 9113082 49.47 µM -1.75399718314599 0.146055349526739 no 2971 0.0397154949069815 1057 17018038
SGTC_996 3970-0799 1.8 µM -1.75519726420839 0.14588329215365 no 2972 0.0396127858534316 1034 6615648 YGL040C HEM2
SGTC_1999 st074831 12.5 µM -1.75973286462115 0.145234247120517 no 2973 0.039226555377225 1044 17112523
SGTC_2447 5741742 33.78 µM -1.76386010158399 0.144645329878974 no 2974 0.0388777678326879 1049 1776504
SGTC_2610 ononetin 44.17 µM -1.76436731566241 0.144573066428929 no 2975 0.0388350786284187 1046 259632
SGTC_2318 6029776 164 µM -1.76704161327462 0.144192458000256 no 2976 0.0386106297383918 1037 818325
SGTC_3045 9092950 49.47 µM -1.76787682090427 0.144073729061424 no 2977 0.0385407492944129 1046 44120432
SGTC_1520 flindersine 88 µM -1.7706171177198 0.143684645256277 no 2978 0.0383121967278557 1023 68230 Flindersine is a natural alkaloid of the quinoline subtype.
SGTC_3042 9091578 49.47 µM -1.77320615378787 0.143317690388561 no 2979 0.0380972763652844 1031 25236497
SGTC_144 4161-2749 112.381 µM -1.7732208738238 0.143315605867485 no 2980 0.0380960572469286 1039 797501 YMR168C CEP3
SGTC_809 3998-0021 90 µM -1.77460295980218 0.143119978301148 no 2981 0.0379817340944965 1042 715485
SGTC_1138 3761-0006 1.03 µM -1.77614858110835 0.142901416871764 no 2982 0.0378542153504079 1053 12061087
SGTC_556 4058-0063 51.5 µM -1.77694571157078 0.142788785381412 no 2983 0.0377885861976141 1058 6615692
SGTC_2286 7945697 125 µM -1.77785984280151 0.142659696014475 no 2984 0.0377134385084991 1037 1245733
SGTC_1186 1319-0216 26 µM -1.77931451144603 0.14245443720159 no 2985 0.0375941065827616 1049 4565136
SGTC_130 0136-0219 337.655 µM -1.77935729067099 0.142448403929104 no 2986 0.0375906019142886 1045 234244
SGTC_2879 9041815 71.43 µM -1.77987599649028 0.142375263164997 no 2987 0.0375481283998358 1063 4942971
SGTC_2523 spermine 47.74 µM -1.78974211080803 0.140988916128298 no 2988 0.036747689645123 1047 1103 A DNA binding polyamine.
SGTC_68 0986-0284 82.829 µM -1.7916653127392 0.140719745421718 no 2989 0.0365932970521184 1023 423278 YIL048W NEO1
SGTC_3271 9137798 49.47 µM -1.79354837031928 0.14045653139777 no 2990 0.0364426417806034 1018 6498326
SGTC_3041 9091929 49.47 µM -1.79406802837186 0.140383952419331 no 2991 0.0364011556749428 1041 25236887
SGTC_857 0438-0306 1.35 µM -1.79577273493236 0.140146040324626 no 2992 0.0362653343252222 1045 4686136
SGTC_2299 7976368 114.88 µM -1.7967652681911 0.140007646727193 no 2993 0.0361864461838363 1043 2979718
SGTC_204 PMA1.184 62.41 µM -1.79775424719009 0.139869841111588 no 2994 0.0361079803465564 1064 2252213 YGL008C PMA1
SGTC_640 3381-0960 37.1 µM -1.80032426587525 0.139512162560771 no 2995 0.0359047257410697 1061 1745025
SGTC_97 0535-0701 19.132 µM -1.80147752734867 0.13935186148834 no 2996 0.0358138231193505 1011 2832013 YGL099W LSG1
SGTC_2810 7959871 45.46 µM -1.80206434921902 0.139270342526854 no 2997 0.0357676409601917 1041 2974535
SGTC_1888 azatryptophan 97.5 µM -1.80236812128678 0.1392281564675 no 2998 0.0357437536481946 1058 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides
SGTC_57 miconazole 162.5 nM -1.80266183003436 0.139187376211437 no 2999 0.0357206701043037 1025 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_3342 9147791 14.508 µM -1.80609325755596 0.13871153881578 no 3000 0.0354518869185044 1049 1838168
SGTC_2518 prenyletin 46.28 µM -1.80975892077847 0.138204445286661 no 3001 0.0351665904374192 1049 3873459 A coumarin with calcium channel inhibitory activity.
SGTC_1181 1222-0449 220 µM -1.81149356137231 0.137964922993897 no 3002 0.0350322424196921 1054 658318
SGTC_2988 9073640 71.4286 µM -1.81219649529704 0.137867941280754 no 3003 0.0349779202075109 1054 9102229
SGTC_2048 5246248 200 µM -1.81483914078502 0.137503759460167 no 3004 0.0347743167089953 1045 677046
SGTC_182 3448-4371 550.524 µM -1.81485879493285 0.137501053393296 no 3005 0.0347728061021111 1048 3491403
SGTC_2581 avocatin a 64 µM -1.8188250264806 0.136955709581417 no 3006 0.0344690644834871 1059 6710728 A skin care supplement.
SGTC_1096 rimcazole 32.2 µM -1.82698587909947 0.135838273731154 no 3007 0.0338509462854087 1050 18528119 A dopamine reuptake inhibitor.
SGTC_1921 5740136 50 µM -1.8291532978444 0.135542549223861 no 3008 0.0336883232371847 1046 1774243
SGTC_889 0919-1524 82.7 µM -1.83034221941568 0.13538051921333 no 3009 0.0335993909637346 1053 3905452
SGTC_1976 st070609 63.5 µM -1.83044108331455 0.135367051707973 no 3010 0.0335920045759738 1054 682556
SGTC_2013 4024628 200 µM -1.8342904416702 0.13484339561872 no 3011 0.0333054461254622 1059 5230760
SGTC_424 splitomicin 100 mM -1.83453215337987 0.134810560261535 no 3012 0.0332875197198097 1062 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_261 5-fluorouridine 15.376 µM -1.83654083798593 0.134537902473707 no 3013 0.0331388540268719 1059 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_337 1315-0038 354 µM -1.84420565689885 0.133500963556391 no 3014 0.0325765871367002 1054 1626437
SGTC_826 1683-5028 118 µM -1.8486908801053 0.132896733712864 no 3015 0.0322512306631852 1056 722377
SGTC_3261 9137475 49.47 µM -1.84880436922659 0.132881469414247 no 3016 0.0322430331194666 1050 17027690
SGTC_414 piperonyl butoxide 100 µM -1.85093029575569 0.132595755172198 no 3017 0.0320897908163777 1058 5794 A potent inhibitor of cytochrome P450.
SGTC_3039 9090270 49.47 µM -1.85442180892833 0.132127431554004 no 3018 0.0318394185389584 1041 17173750
SGTC_3168 9103419 49.47 µM -1.85929883901106 0.131475176944385 no 3019 0.0314923957384015 1068 16649256
SGTC_823 0417-1665 178 µM -1.86143094075556 0.131190728830962 no 3020 0.0313416722918404 1058 3429856
SGTC_539 4859-0462 2.54 µM -1.86144021453111 0.131189492526486 no 3021 0.0313410180113623 1039 46499474 YNL221C | YBR257W POP1 | POP4
SGTC_2935 9038016 29.96 µM -1.86251427220351 0.13104636230864 no 3022 0.0312653178016851 1045 6463195
SGTC_1551 6-bromo-3'-methylflavone 63.5 µM -1.86284057321406 0.131002900417823 no 3023 0.0312423498879299 1062 688751
SGTC_2740 felodipine 17.08 µM -1.86650214587579 0.130515877566896 no 3024 0.0309855720585061 1066 3333 L-type calcium channel blocker
SGTC_409 arachidonic acid 100 µM -1.86773286467133 0.130352462154045 no 3025 0.030899657663058 1045 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes.
SGTC_886 0866-0150 153 µM -1.86962961416873 0.130100888131426 no 3026 0.0307676349518617 1058 271463
SGTC_150 3970-0969 77.2 µM -1.87356717375261 0.129579706064948 no 3027 0.0304950530230813 1049 6615640
SGTC_407 eburnamonine 100 µM -1.87749865054405 0.129060773868924 no 3028 0.0302248910595446 1047 3195
SGTC_3136 9095672 49.47 µM -1.87964271849248 0.128778377317939 no 3029 0.0300783935751564 1053 17217380
SGTC_2699 st077704 54.6 µM -1.88009283326519 0.128719146899455 no 3030 0.0300477135234603 1059 645852
SGTC_3069 9117009 49.47 µM -1.88285199723637 0.128356482699762 no 3031 0.0298602140472916 1055 41904981
SGTC_2995 9067767 71.4286 µM -1.88796777554473 0.127685943801223 no 3032 0.0295151383306123 1049 11673567
SGTC_2482 5981709 142.65 µM -1.89195101799929 0.127165538288644 no 3033 0.0292487536691166 1047 877755
SGTC_2160 5660466 132.927 µM -1.89250034351887 0.127093885574406 no 3034 0.0292121739602754 1055 2859134
SGTC_1697 st025554 27.742 µM -1.89769120314222 0.126418189157193 no 3035 0.0288683860338671 1057 1269519
SGTC_2382 9035899 200 µM -1.89871571056969 0.126285124878722 no 3036 0.0288009323891966 1063 6462679
SGTC_1284 0929-0043 16 µM -1.89977665071153 0.126147431583034 no 3037 0.028731218171439 1058 1239883
SGTC_2778 tioconazole 65.09 nM -1.90002079475422 0.126115760355235 no 3038 0.0287151953782154 1026 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_2872 9044037 25.97 µM -1.91461249612732 0.124232931608368 no 3039 0.0277709701543099 1072 6465195
SGTC_2852 9023854 51.95 µM -1.91694779712254 0.123933432695762 no 3040 0.0276222819750943 1056 19798528
SGTC_1470 k295-0292 231 µM -1.9234735926944 0.123099189318124 no 3041 0.0272102999046478 1077 5045612
SGTC_3125 9127534 49.47 µM -1.92387603093613 0.123047871659473 no 3042 0.0271850621583549 1050 1639235
SGTC_1450 4112-4260 37.6 µM -1.92678525061409 0.122677343156123 no 3043 0.0270031991766939 1048 1633175
SGTC_1688 st021091 57.6 µM -1.92749364461405 0.122587238206515 no 3044 0.0269590696660489 1072 3656366
SGTC_1901 st060216 58.6 µM -1.92772109481206 0.12255831727959 no 3045 0.0269449133952579 1045 688792
SGTC_3149 9097855 49.47 µM -1.93067555530434 0.122183084296103 no 3046 0.0267615938632692 1058 25236625 YMR079W SEC14
SGTC_953 1188-0045 9.7 µM -1.94156411272033 0.120807143600694 no 3047 0.0260949454587585 1036 6144426
SGTC_3188 9110789 49.47 µM -1.94237097830088 0.120705619185081 no 3048 0.0260461030163869 1048 849217
SGTC_1757 st041620 31.8375 µM -1.94406895050965 0.120492166891274 no 3049 0.0259435684592092 1069 5289815
SGTC_1522 st012842 45.6 µM -1.94459840675843 0.120425663280504 no 3050 0.0259116656105159 1002 3491067 YOR116C RPO31
SGTC_2739 tacrine 100.86 µM -1.94570426229537 0.12028684306555 no 3051 0.0258451371850139 980 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders.
SGTC_1403 3909-7815 62.9 µM -1.94929697351797 0.119836621185087 no 3052 0.0256299849059643 1060 6615483
SGTC_3202 9113761 49.47 µM -1.95098840179674 0.119625071109211 no 3053 0.0255292127450405 1052 4798415
SGTC_2994 9053520 71.4286 µM -1.95543387960163 0.1190703232643 no 3054 0.0252659402655546 1053 4647384
SGTC_3090 9117696 49.47 µM -1.95594112803283 0.119007139750143 no 3055 0.0252360448370243 1056 7923821
SGTC_802 4112-3352 742 µM -1.95740313988753 0.1188251621445 no 3056 0.0251500448154062 1051 704594
SGTC_1449 4112-4002 201 µM -1.96982147096327 0.117287366631114 no 3057 0.0244294174696413 1063 2059539
SGTC_2085 5307070 144.047 µM -1.97236806502167 0.116973764563539 no 3058 0.0242838023409508 1064 2840351
SGTC_517 1365-0151 113 µM -1.97367232855646 0.116813380445345 no 3059 0.0242095067846309 1059 768657
SGTC_1975 st070967 30.8 µM -1.9739570297067 0.116778391737521 no 3060 0.0241933145899348 1053 261391
SGTC_1603 st002045 67.8 µM -1.97410123153121 0.11676067270681 no 3061 0.024185116675027 1068 5887985
SGTC_2478 5763493 32.33 µM -1.97699906617383 0.116405000574417 no 3062 0.0240208678753778 1045 1365576 YLR208W SEC13
SGTC_2250 alverine citrate 130 µM -1.98047443273119 0.115979458260698 no 3063 0.0238251217367299 1034 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1
SGTC_2574 2',4'-dihydroxychalcone 14.64 µM -1.98102133349677 0.11591259353239 no 3064 0.0237944406074179 1042 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_1345 1488-0192 31.4 µM -1.98454058300378 0.115482980671583 no 3065 0.0235978043028091 1064 658348
SGTC_865 0488-0499 301 µM -1.98747236780628 0.115125947503198 no 3066 0.0234350375315109 1059 9634651
SGTC_2717 st081029 62.2815 µM -1.98966454747624 0.1148594968637 no 3067 0.0233139502749949 1073 5292846
SGTC_2208 7283366 200 µM -1.98976740667247 0.114847005524727 no 3068 0.023308281700584 1064 898663
SGTC_3265 9137266 49.47 µM -1.98992361744769 0.114828036956997 no 3069 0.0232996751371056 1065 17224265
SGTC_568 1193-0097 7.48 µM -1.99290484214232 0.114466455953504 no 3070 0.0231359340056204 998 3646150
SGTC_183 3914-0051 30.55 µM -1.99771164053884 0.113885166548789 no 3071 0.0228739657393348 1062 1596232
SGTC_3190 9110366 49.47 µM -1.99988484264533 0.113623051384414 no 3072 0.0227563501210861 1063 17123768
SGTC_461 N-acetylfarnesylcysteine 136 µM -1.9999085564637 0.113620193577532 no 3073 0.0227550695245743 1086 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ).
SGTC_479 n-linoleoylglycine 10 µM -2.00241443920495 0.11331849263729 no 3074 0.0226200884033473 1075 6433346 An anti-infammatory.
SGTC_1104 tacrolimus 29.8 µM -2.00776021188659 0.11267678811919 no 3075 0.0223343893927161 1051 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41
SGTC_1055 3448-0672 86 µM -2.01065029753073 0.112330946017594 no 3076 0.0221812036696857 1057 748378
SGTC_1352 1496-0991 99 µM -2.01366331258358 0.111971201854949 no 3077 0.0220224471586958 1067 3000039
SGTC_2297 7971671 152.32 µM -2.01467745539742 0.111850302009856 no 3078 0.0219692279473754 1052 909016
SGTC_2328 6201408 200 µM -2.01519298749798 0.111788879259606 no 3079 0.0219422160044275 1053 2890418
SGTC_1880 MG-132 525 µM -2.01616438224826 0.111673208603552 no 3080 0.0218913947717924 1043 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1
SGTC_3340 9146634 11.102 µM -2.01744318287328 0.111521063605182 no 3081 0.0218246423329835 1056 4907387
SGTC_89 0302-0250 142.109 µM -2.02239500746302 0.110933320802579 no 3082 0.0215677802163447 1083 4203518 YLR208W SEC13
SGTC_1442 4112-3290 3 µM -2.02316471297296 0.110842162408656 no 3083 0.0215280842194494 1081 704353
SGTC_1786 berberine 21.6 µM -2.0266386793736 0.110431398508099 no 3084 0.0213496889218133 1017 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_277 nystatin 15.5 µM -2.03136947672298 0.109873782889656 no 3085 0.0211087641730265 1074 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_686 1319-0111 510 µM -2.03207164149079 0.109791191767733 no 3086 0.0210732018973367 1061 4562600
SGTC_3260 9137109 49.47 µM -2.03632311922506 0.109292069460721 no 3087 0.0208589598918974 1057 17478346
SGTC_1333 1482-0047 286 µM -2.03873544603174 0.109009588892635 no 3088 0.0207382190455725 1062 3811116
SGTC_2968 9090663 33.37 µM -2.03895764629564 0.108983595928336 no 3089 0.0207271273917372 1035 25236811
SGTC_2333 9017922 200 µM -2.04097175104765 0.108748189353428 no 3090 0.0206268175213177 1051 3163164
SGTC_35 0133-0054 64.071 µM -2.04128819906577 0.108711236484573 no 3091 0.0206110946774094 1052 99677
SGTC_1924 st058459 75.1 µM -2.04446960215436 0.108340233302608 no 3092 0.0204535887164233 1057 688683
SGTC_2684 capsaicin 100 µM -2.04524363419859 0.108250106584548 no 3093 0.0204154223172665 1063 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_259 usnic acid 108.925 µM -2.04571632739065 0.108195093696326 no 3094 0.0203921441974436 1078 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_998 3996-0085 177 µM -2.04645927998263 0.108108668207272 no 3095 0.0203556024224557 1075 715391
SGTC_570 0987-0065 62.6 µM -2.04989213340402 0.107709979815195 no 3096 0.02018747901659 1046 3104428
SGTC_2302 7771753 200 µM -2.05044914556354 0.107645388951116 no 3097 0.0201603107736351 1045 2203047
SGTC_1434 4073-0095 163 µM -2.05588125027835 0.107016947446075 no 3098 0.019896981905114 1067 24133745
SGTC_3329 9141233 27.5565 µM -2.05978718594018 0.106566707257464 no 3099 0.0197094450609936 1043 4909101 YNL103W MET4
SGTC_3160 9100216 49.47 µM -2.06107008569663 0.106419125161674 no 3100 0.0196481771128685 1066 17191039
SGTC_2594 a-mangostin 100 µM -2.06179622444314 0.106335657117737 no 3101 0.0196135703431604 1069 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis.
SGTC_3144 9087057 49.47 µM -2.06242375178934 0.106263562328103 no 3102 0.0195837049626153 1061 17249618
SGTC_1814 st052110 31.539 µM -2.06811183044694 0.105611685376251 no 3103 0.0193147542483912 1064 674163
SGTC_2143 5623677 140.463 µM -2.06965224660959 0.105435646038416 no 3104 0.0192424608193191 1051 5375313
SGTC_2642 cholecalciferol 100 µM -2.07080405793776 0.105304155357825 no 3105 0.0191885554333893 1064 9821465 A vitamin D precursor, similar to steriods.
SGTC_601 0986-0029 62.9 µM -2.07455118322698 0.10487720473866 no 3106 0.0190140752154291 1051 24747981
SGTC_1401 3807-4679 7.6 µM -2.07552457302833 0.104766501240912 no 3107 0.0189689719287388 1068 3291456
SGTC_167 3672-0051 66.205 µM -2.0777936440393 0.104508768685635 no 3108 0.0188641847492442 1063 3237971
SGTC_3187 9109394 49.47 µM -2.07872742287532 0.104402838887281 no 3109 0.0188212054845557 1062 17098090
SGTC_3132 9126706 49.47 µM -2.08150806948633 0.104087857446823 no 3110 0.0186937131306868 1066 850858
SGTC_1010 4112-3296 15.2 µM -2.08280592960518 0.103941076687026 no 3111 0.018634458440255 1058 704384
SGTC_505 gw-5074 63.9 µM -2.08514347667167 0.10367709186905 no 3112 0.0185281394047661 1061 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases.
SGTC_1194 1488-0194 225 µM -2.08719767984817 0.103445507625328 no 3113 0.018435134566288 1078 1391452
SGTC_3283 9109332 35.8195 µM -2.08903747111353 0.103238414422619 no 3114 0.0183521751243002 1044 17027281
SGTC_23 0213-0011 39.996 µM -2.09173624794012 0.102935175794357 no 3115 0.0182310580298558 1066 627608
SGTC_2506 ethyl hematommate 54.16 µM -2.09303384249507 0.102789606689557 no 3116 0.0181730668108772 1073 3940691 An allergen.
SGTC_780 0109-0199 192 µM -2.09804970420251 0.102228314985434 no 3117 0.0179503774340166 1067 610414
SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM -2.0987457402671 0.10215060271301 no 3118 0.017919660118741 1071 676296 Flavone; oxidizing agent.
SGTC_3024 9090631 49.47 µM -2.10228966614265 0.101755590604615 no 3119 0.0177639546288389 1065 25236383
SGTC_2980 9014342 25.29 µM -2.10304264103767 0.101671806145467 no 3120 0.017731021109692 1033 2996599
SGTC_3075 9116269 49.47 µM -2.1059760032065 0.101345886261102 no 3121 0.0176032184318952 1062 17015205 YNL244C SUI1
SGTC_1554 st069299 38.7 µM -2.10604588651535 0.101338130962564 no 3122 0.0176001833231565 1060 24207999
SGTC_3128 9127691 49.47 µM -2.10698837474756 0.101233580585859 no 3123 0.0175592936387301 1064 41316314
SGTC_2716 st080858 38.6235 µM -2.10945510586642 0.1009603177858 no 3124 0.0174526586154454 1057 5296050
SGTC_3224 9130643 49.47 µM -2.10981652909363 0.100920324775116 no 3125 0.0174370810854568 1054 17644395
SGTC_890 0929-0006 47.2 µM -2.11026386061216 0.100870841644075 no 3126 0.0174178173053268 1076 1378169
SGTC_1794 st048918 76.9 µM -2.11442546645043 0.100411338766811 no 3127 0.0172394722344859 1039 672303
SGTC_2650 prasterone 100 µM -2.1165827801524 0.100173741398469 no 3128 0.017147636419493 1073 16759247 A steroid and weak partial agonist of the androgen receptor.
SGTC_1795 st049545 62.3 µM -2.11855439798749 0.0999569549719182 no 3129 0.017064071535226 1063 5291882
SGTC_3249 9135183 49.47 µM -2.11996413528705 0.0998021595210521 no 3130 0.0170045349804477 1033 4902779
SGTC_1152 3909-8331 15.9 µM -2.1301578456854 0.098688053047712 no 3131 0.0165792919830782 1061 16001939
SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM -2.13336542552757 0.0983393752247157 no 3132 0.0164473804967894 1074 2374 Ca(2+)-ATPase inhibitor.
SGTC_537 1334-0398 209 µM -2.13346709886206 0.0983283376640472 no 3133 0.0164432139229981 1067 5846986
SGTC_211 3455-0679 143.504 µM -2.13883152625266 0.0977472666148445 no 3134 0.0162246576081487 1061 748649
SGTC_618 k072-0232 33.2 µM -2.14271960041288 0.097327689371221 no 3135 0.0160678102710922 1043 5872756 YGL099W LSG1
SGTC_1738 st035555 74 µM -2.15135570584073 0.0964004634100286 no 3136 0.015724067251556 1065 5331140
SGTC_3139 9095020 49.47 µM -2.15323551632306 0.0961994983489518 no 3137 0.0156500868624243 1063 25236292
SGTC_639 0833-0042 114 µM -2.15397395279873 0.0961206385648971 no 3138 0.0156211073256249 1079 5978911 YPR085C | YHR062C ASA1 | RPP1
SGTC_129 0088-0017 176.636 µM -2.15893926280305 0.095591612537404 no 3139 0.0154274396499095 1077 182446
SGTC_564 3555-0129 330 µM -2.15939615112365 0.0955430415002079 no 3140 0.015409723123645 1061 563260
SGTC_2422 chlorphenesin carbamate 384.24 µM -2.16780529511162 0.0946523203527756 no 3141 0.0150867518990978 1064 2724 A muscle relaxant with antifungal properties.
SGTC_3058 9093861 49.47 µM -2.17023674888783 0.0943959179813019 no 3142 0.0149944577359483 1060 17217477
SGTC_3310 9130229 44.1445 µM -2.17065303556619 0.0943520709973552 no 3143 0.0149787049043663 1070 7761258
SGTC_40 0327-0103 19.753 µM -2.17848807482244 0.0935296151859255 no 3144 0.0146848595511007 1046 409036
SGTC_336 4111-0029 111 µM -2.18231645477488 0.0931296753199396 no 3145 0.0145430927098601 1073 3131175
SGTC_1829 berberine 14.4 µM -2.18461132386088 0.0928905436005414 no 3146 0.0144586784710825 1023 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_569 4130-2812 160 µM -2.18898609950886 0.0924359379967857 no 3147 0.014298925179585 1076 743552
SGTC_1900 st060200 72.8 µM -2.19542999232683 0.0917693210521126 no 3148 0.0140663838189565 1060 688945
SGTC_3086 9117350 49.47 µM -2.19621142660908 0.0916887248717377 no 3149 0.0140384069426023 1077 2679265
SGTC_207 4185-0010 4.486 µM -2.19724739011275 0.0915819577208352 no 3150 0.0140013913670416 1068 3761753
SGTC_280 3448-3607 3.04 µM -2.20224332654671 0.0910683660984983 no 3151 0.0138240625404925 1045 626179
SGTC_1642 st009582 77.7 µM -2.21321482035786 0.0899479783688438 no 3152 0.0134414194091907 1076 6739311
SGTC_3010 9080089 71.4286 µM -2.21929101862118 0.0893319127656279 no 3153 0.0132334661213898 1076 17027233
SGTC_1796 st049173 110.4 µM -2.22058095123474 0.0892015314146938 no 3154 0.0131896785898428 1068 94134
SGTC_2386 9075165 157.42 µM -2.2271853861301 0.0885361987067775 no 3155 0.0129674432032799 1076 16452277
SGTC_2499 avocadenofuran 51.48 µM -2.23325094137746 0.0879284160952677 no 3156 0.0127662003515706 1073 6857792 A insecticide and lysyl oxidase inhibitor.
SGTC_3096 9117468 49.47 µM -2.23964710678703 0.0872908818548278 no 3157 0.0125569209718206 1077 41316311
SGTC_2261 9010538 184.68 µM -2.24822400916769 0.086441408884372 no 3158 0.0122809547315114 1070 6457250
SGTC_1306 1185-0270 9.02 µM -2.25147972364344 0.0861205801475625 no 3159 0.0121775848558339 1071 1548076
SGTC_2501 sodium tetradecyl sulfate 13.37 µM -2.25508969514578 0.0857658841654408 no 3160 0.0120638496663338 1076 23665772 A membrane-active detergent.
SGTC_2438 5259590 200 µM -2.25703685705987 0.0855750212866943 no 3161 0.0120028859103905 1073 1201127
SGTC_1335 1486-0900 202 µM -2.2573117561771 0.0855481010241495 no 3162 0.0119943006421564 1067 X1335
SGTC_1077 5-fluorocytosine 377 nM -2.2578326052732 0.0854971128154715 no 3163 0.0119780488076598 1077 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_3230 9131665 49.47 µM -2.27078281781932 0.0842366663143704 no 3164 0.0115800642998967 1071 15943720
SGTC_87 0100-0052 35.5 µM -2.27455505483708 0.0838721497539155 no 3165 0.0114663174496774 1085 200187 YGR083C | YDR527W GCD2 | RBA50
SGTC_153 4077-0274 519.67 µM -2.27586960429515 0.0837454017304979 no 3166 0.0114269076123431 1069 3121976
SGTC_2565 isoliquiritigenin 100 µM -2.27862466919596 0.0834802269905656 no 3167 0.011344693102233 1060 638278 Binds to benzodiazepine receptor 65X better than valium.
SGTC_3012 9080433 71.4286 µM -2.27917291265882 0.0834275339709359 no 3168 0.011328394307974 1072 17688859
SGTC_3225 9130819 49.47 µM -2.27930230135562 0.0834151017537972 no 3169 0.0113245506655592 1079 4547121
SGTC_3345 9148410 3.559 µM -2.28054177564909 0.0832960783362731 no 3170 0.0112877880261319 1059 4903596
SGTC_2602 kawain 100 µM -2.28084710795641 0.0832667776966761 no 3171 0.0112787478502483 1061 5369129
SGTC_455 paf C-16 10 µM -2.2907319825518 0.0823223753434584 no 3172 0.0109894598323086 1072 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis.
SGTC_3116 9124943 49.47 µM -2.29727223706568 0.0817019670411572 no 3173 0.010801622265324 1066 41905195 YPL160W CDC60
SGTC_486 niguldipine 82 µM -2.30646068856038 0.0808363142035078 no 3174 0.0105424521442421 1087 1236 A calcium channel blocker.
SGTC_1488 4013-0813 75.9 µM -2.31286895917817 0.0802366960149747 no 3175 0.010364922464754 1085 2910057
SGTC_1849 st056239 19.2 µM -2.31338749888555 0.0801883239545836 no 3176 0.0103506718931344 1072 5393181
SGTC_1257 0669-0121 16 µM -2.31556939193696 0.0799850271894458 no 3177 0.0102908958332123 1071 4307855
SGTC_374 0880-0231 82.3 µM -2.31844084178313 0.0797180755416179 no 3178 0.01021268728405 1052 6833587
SGTC_1708 st033234 31.827 µM -2.31987315426595 0.0795851691628079 no 3179 0.0101738701096333 1079 674664
SGTC_790 1575-0012 79.1 µM -2.32466940515319 0.0791413385943195 no 3180 0.0100448222222254 1060 378741 YLR208W SEC13
SGTC_1883 5-benzylidenerhodanine 20 µM -2.32507477813706 0.0791039126735624 no 3181 0.0100339810192349 1065 1273210
SGTC_2646 retinol 96.75 µM -2.32751951959212 0.0788784868620492 no 3182 0.00996881566147725 1077 445354 A vitamin A analog and teratogen.
SGTC_1294 1000-1494 117 µM -2.32772557995237 0.0788595086177063 no 3183 0.00996333997723149 1083 712797 YDL207W GLE1
SGTC_847 0342-0274 5.54 µM -2.33570274187701 0.078127464977782 no 3184 0.00975336975001264 1081 18097
SGTC_1601 4'-hydroxyflavanone 55.5 µM -2.33981035253458 0.0777525363230331 no 3185 0.00964676707996566 1084 165506
SGTC_2130 NSC 7 2.4545 µM -2.34476789740283 0.0773018493207348 no 3186 0.00951946373270752 1082 21448
SGTC_2918 7977171 22.06 µM -2.34648058442258 0.0771466122056833 no 3187 0.00947582678351399 1081 2236483
SGTC_1143 3454-2408 5.08 µM -2.35154419646603 0.0766890343295504 no 3188 0.00934783423616869 1053 X1143
SGTC_344 k064-0035 6.43 µM -2.3550926919271 0.0763696033345661 no 3189 0.00925904290913337 1050 5088750
SGTC_2254 7938975 95.19 µM -2.35982712237999 0.0759449937092178 no 3190 0.00914172659453828 1082 2969277
SGTC_1854 st056233 32.9 µM -2.36274019857204 0.0756846278537236 no 3191 0.00907019081522252 1077 5393174
SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM -2.36806568203159 0.0752104037286778 no 3192 0.00894068055094472 1074 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_198 3454-2873 16.191 µM -2.3720119674414 0.0748604584142585 no 3193 0.00884575883965022 1082 710957
SGTC_412 gemfibrozil 100 µM -2.37807026305919 0.0743256452200811 no 3194 0.0087017546775433 1076 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels.
SGTC_2551 apiole 73.87 µM -2.38375577774657 0.0738263987545246 no 3195 0.00856848545844694 1084 10659 A possible DNA adduct former.
SGTC_1698 5-fluorocytosine 1.055 µM -2.38506525029042 0.073711777590973 no 3196 0.00853804615199284 1077 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_3213 9129884 49.47 µM -2.39957506423834 0.0724507891401668 no 3197 0.00820705701529468 1070 17190742
SGTC_705 1124-0212 310 µM -2.40198232298796 0.07224319204764 no 3198 0.00815324819606297 1073 9554485
SGTC_2641 levomentholum 100 µM -2.41601021454001 0.0710425127485858 no 3199 0.00784581057199506 1083 16666
SGTC_2770 toltrazuril 17.5 µM -2.42074691084455 0.0706405679166616 no 3200 0.00774432833758591 1063 68591 Kills coccidiodes.
SGTC_1643 st009866 20.2 µM -2.43554583632182 0.0693960225468616 no 3201 0.00743467029783986 1068 3156273 YOR207C RET1
SGTC_636 0kpi-0074 126 µM -2.4360576696627 0.0693532829953419 no 3202 0.00742415852873438 1080 616434
SGTC_3234 9132280 49.47 µM -2.43762861615347 0.0692222310696693 no 3203 0.00739197697895625 1082 17612295
SGTC_2860 9025725 38.96 µM -2.44288485661099 0.0687851304490414 no 3204 0.00728519256179069 1086 40546248
SGTC_1406 3909-7906 11.9 µM -2.44504292005555 0.0686062867685696 no 3205 0.00724174523903439 1047 X1406
SGTC_848 0368-0089 85.6 µM -2.44531966466503 0.0685833782749019 no 3206 0.00723619022583139 1073 762535
SGTC_1517 deoxycholic acid methyl ester 49.2 µM -2.44596244566575 0.0685301926179144 no 3207 0.00722330236891718 1080 229346 A bile salt which induces apoptosis.
SGTC_737 1950-0117 57.9 µM -2.44797482777705 0.0683638877082962 no 3208 0.00718308459709003 1079 5393513
SGTC_348 k064-0012 10.7 µM -2.46718951004476 0.0667916150391128 no 3209 0.00680891322704218 1072 5066323
SGTC_3207 9114163 49.47 µM -2.47474299026745 0.0661812562092489 no 3210 0.00666660430635973 1076 849233
SGTC_2221 6807166 181.081 µM -2.48938692275248 0.0650102704811331 no 3211 0.00639818087085672 1086 674925
SGTC_286 k060-0067 22.9 µM -2.49384607564596 0.0646569118761146 no 3212 0.00631836650711783 1084 5985051
SGTC_1617 st002906 78 µM -2.49439629502513 0.0646134141862351 no 3213 0.00630857947399307 1086 5150859
SGTC_2667 digitoxin 100 µM -2.49797192814346 0.0643312954576175 no 3214 0.00624530422576618 1089 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_2437 5741531 144.16 µM -2.49892548829807 0.0642562211352641 no 3215 0.00622852500598742 1064 2262990
SGTC_1164 k060-0068 93.7 µM -2.50112255741142 0.0640835038574059 no 3216 0.00619001639049557 1091 5963676
SGTC_3164 9100705 49.47 µM -2.50441114840885 0.0638256539470144 no 3217 0.00613277041387863 1084 17174235
SGTC_712 r015-0009 80.6 µM -2.50694571843997 0.0636274760830287 no 3218 0.00608897058272354 1089 6813872 YLR060W FRS1
SGTC_3251 9135047 49.47 µM -2.51620813129531 0.0629073183380493 no 3219 0.00593125536652685 1090 17682963
SGTC_1304 1165-0502 251 µM -2.52156330111064 0.0624938573269637 no 3220 0.00584173260411269 1085 767425
SGTC_46 0329-0187a 2.197 µM -2.52278146860291 0.0624001017078406 no 3221 0.00582153653510658 1068 46494817
SGTC_503 tyrphostin 8 294 µM -2.53023933862998 0.0618284999160735 no 3222 0.00569923719269158 1087 92970 A tyrosine kinase inhibitor. YOR207C RET1
SGTC_1937 st074714 47.2 µM -2.53029894065784 0.0618239482897595 no 3223 0.00569826905396934 1080 17250970
SGTC_581 0958-0271 211 µM -2.53244247330732 0.0616604269807675 no 3224 0.00566354772409811 1077 4591145
SGTC_3243 9134147 49.47 µM -2.53478161445001 0.0614823690431479 no 3225 0.00562587234466148 1071 24282180
SGTC_2498 4'-Methoxychalcone 54.63 µM -2.53531210330602 0.0614420435820635 no 3226 0.0056173590485195 1082 641818 YHR062C RPP1
SGTC_2748 diazoxide 86.69 µM -2.53532281634838 0.0614412294359341 no 3227 0.00561718724330764 1088 3019 A potassium channel activatior.
SGTC_1828 st055811 49 µM -2.53563421727441 0.0614175679583183 no 3228 0.00561219534096913 1089 5877589
SGTC_1560 lithocholic acid 53.1 µM -2.5372508786492 0.0612948419943775 no 3229 0.00558634276928496 1074 9903 A bile acid which acts as a detergent.
SGTC_3114 9122766 49.47 µM -2.5435452647027 0.0608188393482375 no 3230 0.00548669190689353 1078 17176985
SGTC_413 propylparaben 100 µM -2.54820970935368 0.0604679668016329 no 3231 0.00541386799168743 1080 7175 A pharmaceutical preservative.
SGTC_2164 5685496 200 µM -2.55383742832133 0.0600467446278799 no 3232 0.00532714946112898 1079 759046
SGTC_940 3232-1287 54.8 µM -2.561691448386 0.0594627338315654 no 3233 0.00520819068189113 1079 1585493 YIL048W NEO1
SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM -2.56224530054493 0.0594217190292721 no 3234 0.00519989182026424 1078 756377
SGTC_904 1141-0088 396 µM -2.58142006469574 0.0580153845623541 no 3235 0.00491973875213359 1090 1378119
SGTC_1283 0922-0125 16.4 µM -2.58228038088901 0.0579529048721336 no 3236 0.0049074904620366 1075 3360884
SGTC_2898 9056270 58.44 µM -2.58407119363575 0.0578230183366562 no 3237 0.00488208184181846 1079 19154699
SGTC_2670 beta-carotene 100 µM -2.59068439520057 0.0573453490752187 no 3238 0.00478926453804625 1092 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.)
SGTC_317 4495-0002 170 µM -2.59404762761427 0.0571036178499448 no 3239 0.00474266730267051 1083 15991618
SGTC_3129 9127257 49.47 µM -2.59984308306162 0.0566889541810133 no 3240 0.00466331985650358 1082 837894
SGTC_1597 7-benzyloxygramine 47.5 µM -2.60002673216728 0.0566758530023817 no 3241 0.00466082493413121 1068 260807
SGTC_339 3091-4833 71.4 µM -2.61108128686796 0.0558916257897823 no 3242 0.00451282188048884 1067 3240077
SGTC_3287 9117173 37.0625 µM -2.61644714074715 0.0555140625752319 no 3243 0.00444250600627245 1063 2789709
SGTC_1780 st038448 24.544 µM -2.6172013834974 0.0554611527846005 no 3244 0.00443270101801415 1080 728868 YDL195W SEC31
SGTC_1206 3978-0017 132 µM -2.61957495492893 0.0552949075701518 no 3245 0.00440197113491263 1073 3873677
SGTC_1906 st060206 94.7 µM -2.62592235585801 0.0548522679753035 no 3246 0.00432072633755877 1076 5133468
SGTC_2823 7987624 58.44 µM -2.63318710935917 0.0543490984334417 no 3247 0.00422938667870062 1079 2239440
SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM -2.63487894315548 0.0542324448723452 no 3248 0.00420836476318597 1082 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_943 3253-1379 105 µM -2.64346616567302 0.0536433995661511 no 3249 0.00410309833658729 1073 668464
SGTC_1454 4239-0054 42.6 µM -2.66142941070047 0.0524275950539182 no 3250 0.00389048270639744 1085 1340767
SGTC_1705 st027868 56.3335 µM -2.66154882556338 0.0524195865252861 no 3251 0.00388910295549054 1083 292948
SGTC_253 dyclonine 31.25 µM -2.66753148957238 0.0520196023075667 no 3252 0.00382053641469918 1090 3180 An oral anasthetic.
SGTC_2010 4012422 159 µM -2.66804548969971 0.0519853511131398 no 3253 0.00381469637651859 1081 952393
SGTC_2939 9044578 71.43 µM -2.6805331599455 0.0511587084117973 no 3254 0.00367524907014263 1085 2653634
SGTC_3131 9127911 49.47 µM -2.68195732298482 0.0510651017043055 no 3255 0.00365963982233624 1077 45595681
SGTC_644 1498-1197 63.3 µM -2.68733521841043 0.050712854621861 no 3256 0.0036012314910038 1090 6741615
SGTC_920 mycophenolic acid 780.421 nM -2.69570582699603 0.0501684404698358 no 3257 0.00351198338441646 1086 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_415 dibenzyl ketone 100 µM -2.69669119241034 0.0501046611714863 no 3258 0.00350160908985284 1082 7593
SGTC_1824 st053723 68.6 µM -2.70177286130025 0.0497767680005898 no 3259 0.0034485430872423 1087 675225
SGTC_1572 epiandrosterone 68.9 µM -2.70711699873197 0.0494337881777188 no 3260 0.0033935166788512 1078 441302 A steroid.
SGTC_1270 0831-1170 17.3 µM -2.71494125981845 0.0489350429835428 no 3261 0.00331437633548777 1083 6764716
SGTC_2372 9071633 200 µM -2.73181154019502 0.047873354049078 no 3262 0.00314935795812533 1087 21321366
SGTC_762 1165-0429 115 µM -2.74784525546291 0.0468814814248681 no 3263 0.00299941569227352 1081 5967793
SGTC_2986 9022445 71.43 µM -2.75521098769616 0.0464313835970405 no 3264 0.00293271491784347 1083 6459286
SGTC_2424 5537928 59.2 µM -2.7640900810857 0.0458934270493405 no 3265 0.00285408892066628 1074 5382802
SGTC_1775 st081588 35.1725 µM -2.76793345238915 0.045662127636855 no 3266 0.00282064867223393 1068 1426443 YGL099W LSG1
SGTC_3047 9092122 49.47 µM -2.77160213583764 0.0454422162752824 no 3267 0.00278905848521803 1086 17173831
SGTC_2212 7123476 200 µM -2.77187239257408 0.045426050056533 no 3268 0.00278674403970613 1093 1085715
SGTC_734 2023-0417 80 µM -2.77747509754061 0.0450919480991818 no 3269 0.00273915189014611 1087 3935732
SGTC_2571 chrysanthemic acid 100 µM -2.78105402640102 0.0448795655077526 no 3270 0.00270913596327643 1087 2743 An insecticide.
SGTC_2441 5730946 39.09 µM -2.78265198679977 0.0447849989580295 no 3271 0.00269583026410126 1080 1774275
SGTC_1885 st057546 99.9 µM -2.78630203928142 0.0445695923450294 no 3272 0.00266565851812937 1088 702008
SGTC_364 0083-0097 67.7 µM -2.79637734735782 0.043979330442161 no 3273 0.00258395112283622 1088 5207356
SGTC_884 0851-0618 334 µM -2.80124834336759 0.0436962323631373 no 3274 0.00254526638058468 1079 9642473
SGTC_1663 st014140 55.4 µM -2.80804499230989 0.0433036761803786 no 3275 0.00249216312782304 1087 4207120
SGTC_1602 st001878 87.6 µM -2.82040025070771 0.0425973662279174 no 3276 0.00239818913886212 1081 595405 YLR310C CDC25
SGTC_1616 st002734 56.1 µM -2.82274495619854 0.0424643844618557 no 3277 0.00238072163616496 1082 4026101
SGTC_786 4544-0069 423 µM -2.82619894086075 0.0422691008914493 no 3278 0.00235519996707991 1085 748821 YLR208W SEC13
SGTC_2616 abietic acid 100 µM -2.82847023397474 0.0421410815457879 no 3279 0.00233855251564851 1089 6708678 Abietic acid is an inhibitor of 5α-reductase.
SGTC_942 3253-1115 227 µM -2.8363927493594 0.0416969904709773 no 3280 0.0022813149864143 1092 46497897
SGTC_891 0929-0073 133 µM -2.84284561002319 0.041338087543153 no 3281 0.00223563619971935 1093 5603632
SGTC_490 phenamil 164 µM -2.84504836906204 0.0412161466374916 no 3282 0.00222023398022087 1021 4755 Irreversibly blocks amiloride-sensitive Na+ channels.
SGTC_431 k089-0097 107 µM -2.85789149947117 0.0405109684500486 no 3283 0.00213233093656019 1049 5499420
SGTC_3176 9106582 49.47 µM -2.86431984984252 0.0401617026944145 no 3284 0.00208952896220744 1092 17018027
SGTC_118 0083-0097 135.343 µM -2.87210651845235 0.0397419170458633 no 3285 0.00203872752291982 1088 5207356
SGTC_3119 9125183 49.47 µM -2.88847932740724 0.0388708804068123 no 3286 0.00193554736724939 1092 22695334
SGTC_1426 4048-4480 71.7 µM -2.89315945568315 0.0386247741253994 no 3287 0.00190693810267184 1093 14224343
SGTC_1979 st071809 45.3 µM -2.89658546530942 0.038445422229793 no 3288 0.00188623935325904 1087 4976333
SGTC_1561 5-methoxyflavone 52.9 µM -2.90353127251047 0.0380838917706709 no 3289 0.00184490059289918 1083 94525
SGTC_2215 7188065 200 µM -2.91047566846728 0.0377252118506764 no 3290 0.00180439532143654 1091 940217
SGTC_1908 st060353 56.5 µM -2.9135121669643 0.0375692447042939 no 3291 0.00178693954935425 1088 4227716
SGTC_2742 clothiapine 36.27 µM -2.92851056137776 0.0368065702796258 no 3292 0.00170295130795842 1095 16351 An atypical antipsychotic. YIL048W NEO1
SGTC_122 0236-0016 402.397 µM -2.942863071534 0.0360886402676409 no 3293 0.00162596108485993 1079 6808838
SGTC_2114 5491910 81.25 µM -2.94802703489905 0.035833154514483 no 3294 0.00159904547603333 1090 2849228
SGTC_793 0488-0545 106 µM -2.95343305093168 0.0355672829566894 no 3295 0.00157130383277845 1092 292548
SGTC_990 3985-0011 41.3 µM -2.95537537589943 0.0354721538714881 no 3296 0.00156144417435829 1073 5399565 YGL099W LSG1
SGTC_1709 st033179 39.1045 µM -2.95576158545627 0.0354532634058568 no 3297 0.00155949042727792 1092 573381
SGTC_2820 7989630 71.43 µM -2.96445276906377 0.0350303330874226 no 3298 0.00151610892831329 1085 2984098
SGTC_2744 captopril 92.04 µM -2.98226076419514 0.0341766905196685 no 3299 0.00143064087698009 1095 44093 angiotensin-converting enzyme (ACE) inhibitor
SGTC_297 0986-0032 24 µM -2.9890389355913 0.0338562988510015 no 3300 0.00139928233370517 1089 2847425
SGTC_3021 9087658 49.47 µM -3.00764874074174 0.0329893329168415 no 3301 0.00131638625547632 1091 25237042
SGTC_3017 9080681 49.47 µM -3.03841261202033 0.0315963212339989 no 3302 0.00118914035903423 1092 16451914
SGTC_3095 9117207 49.47 µM -3.05502571976026 0.0308645108902735 no 3303 0.00112520611242803 1092 17015229
SGTC_1822 st052468 42 µM -3.07140865747713 0.030156635249292 no 3304 0.00106525669678864 1092 2873678
SGTC_2745 rifampicin 24.3 µM -3.08110767182587 0.0297439385794452 no 3305 0.00103116028892201 1095 25141428 Inhibits bacterial DNA-dependent RNA polymerase.
SGTC_84 0443-0269 128.823 µM -3.08676951065547 0.0295051989243173 no 3306 0.00101172212750889 1090 6150058
SGTC_2839 9003951 25.97 µM -3.10703516851366 0.0286636686280339 no 3307 0.000944869579432255 1088 2990634
SGTC_79 0052-0007 94.094 µM -3.11624680368187 0.0282878073780206 no 3308 0.000915844507479254 1086 2801472
SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM -3.12178814869648 0.0280636870300123 no 3309 0.000898781204065841 1092 551469
SGTC_1404 3909-7820 48.3 µM -3.13644873813974 0.027477859217402 no 3310 0.000855036644076989 1069 23741373
SGTC_1882 5615643 20 µM -3.14759104239952 0.0270394701332977 no 3311 0.000823109160139885 1091 2253075
SGTC_2032 5185112 25.99 µM -3.15668194285298 0.0266861307608318 no 3312 0.000797876498664281 1094 5718189
SGTC_1219 1469-0211 33.1 µM -3.17444223380186 0.0260069570132182 no 3313 0.000750623847967012 1087 6822282
SGTC_2182 6325192 200 µM -3.18008544507001 0.0257942048299808 no 3314 0.000736158162308008 1085 736248
SGTC_717 1532-0246 73.2 µM -3.23211759685873 0.0239003346887939 no 3315 0.000614382384821974 1091 9561992
SGTC_2867 9039098 71.43 µM -3.27914342974567 0.0222905861174625 no 3316 0.000520613503532782 1086 6463460
SGTC_2176 5809774 33.9695 µM -3.29233004633635 0.0218559664365823 no 3317 0.000496804657726189 1092 2870539
SGTC_2827 7993847 71.43 µM -3.31386429814668 0.0211616081062524 no 3318 0.000460080766433208 1091 2985692
SGTC_1407 3909-7909 12.3 µM -3.34466514236702 0.0202009516859713 no 3319 0.000411909841897389 1085 4411780
SGTC_2741 miltefosine 3.04 µM -3.36414172710782 0.0196127789937321 no 3320 0.000383910513111077 1092 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis.
SGTC_3142 9086498 49.47 µM -3.38120995746899 0.0191093544287642 no 3321 0.000360836883954493 1074 25236367
SGTC_126 0417-1624 672.48 µM -3.38562800208954 0.0189808493985643 no 3322 0.000355077903520864 1092 41912 YDL195W SEC31
SGTC_2843 9000894 45.46 µM -3.38776768594883 0.0189188783257167 no 3323 0.000352319600374953 1093 2242070
SGTC_2953 9074162 66.49 µM -3.3943627351505 0.0187289494509683 no 3324 0.000343942570773296 1088 16451992
SGTC_530 4358-1714 28 µM -3.41893071695528 0.0180356410174225 no 3325 0.000314338658525767 1091 1564641
SGTC_2362 9071156 126 µM -3.43519425296522 0.0175888208806163 no 3326 0.000296064607660848 1093 653133
SGTC_180 1486-1293 102.781 µM -3.46183954730406 0.0168771980467691 no 3327 0.000268248449325006 1093 4140536
SGTC_2900 5328528 85.29 µM -3.47094208811011 0.0166398039798396 no 3328 0.000259317919631227 1086 795359
SGTC_2363 9053361 176 µM -3.48139855219017 0.0163706315736663 no 3329 0.000249401345105722 1094 6469797 YMR079W SEC14
SGTC_2855 9016525 58.44 µM -3.49697336929293 0.0159766182743728 no 3330 0.000235284402600561 1088 43811474
SGTC_444 curcumin 90.4 µM -3.52554898909474 0.0152748263052708 no 3331 0.000211303002913052 1089 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties.
SGTC_74 000s-0487 160.283 µM -3.62182653478865 0.0131017952110027 no 3332 0.000146265129227748 1090 677548
SGTC_263 alizarin 107.927 µM -3.62532390036693 0.0130281633943026 no 3333 0.000144299751917283 1088 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium.
SGTC_3108 9121785 49.47 µM -3.66290486397374 0.012259260336101 no 3334 0.00012468558661878 1073 17140271
SGTC_700 3453-2283 142 µM -3.68646274043017 0.0117975846097764 no 3335 0.000113696358358205 1094 565664
SGTC_452 diindolylmethane 8 µM -3.69862420694236 0.0115652099936902 no 3336 0.000108385633016418 1093 3071 Inhibits expression of several cancer promoting factors.
SGTC_1970 st070122 35.8 µM -3.73075916130086 0.0109702237430454 no 3337 9.54518262400456e-05 1094 102928
SGTC_1909 st060837 51.5 µM -3.79969057090486 0.00978311155956599 no 3338 7.24384339280045e-05 1089 678937
SGTC_2045 5106652 78.05 µM -3.87347939311482 0.00863820017176133 no 3339 5.36462413155879e-05 1095 673349
SGTC_3004 9076122 71.4286 µM -3.88089669878867 0.00852988782523082 no 3340 5.20360206712755e-05 1094 44782551
SGTC_1691 st019933 84.6 µM -3.88407005415281 0.00848391357958522 no 3341 5.13611447536444e-05 1094 6176082
SGTC_713 1488-1073 324 µM -3.9207531983768 0.00796804408132063 no 3342 4.41363164431401e-05 1095 3312542
SGTC_1020 4335-0961 93.3 µM -3.97391115398407 0.00726946504799447 no 3343 3.53509726938931e-05 1093 669075
SGTC_85 0868-0259 160.055 µM -4.17711537383717 0.00507149652404296 no 3344 1.47614648720661e-05 1094 83173
SGTC_651 3253-0966 34.4 µM -4.20944946812086 0.00478258992406421 no 3345 1.27996843018238e-05 1094 781462
SGTC_658 3253-0951 102 µM -4.29022058642248 0.00412400501492131 no 3346 8.92478672548056e-06 1095 1184878
SGTC_3211 9128781 49.47 µM -4.30597281799811 0.00400545622087402 no 3347 8.31267361571542e-06 1087 17194361
SGTC_2976 9009005 19.48 µM -4.41722282727248 0.00325151324620471 no 3348 4.99885749075252e-06 1095 2993148
SGTC_467 ro 31-8220 72.8 µM -4.50850590014509 0.00273102582820028 no 3349 3.26428769453298e-06 1092 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7
SGTC_2367 9070478 135.38 µM -4.70187495440126 0.00186859664822634 no 3350 1.28891679802212e-06 1094 572802
SGTC_1634 st006576 41 µM -4.77656418676585 0.00160797626236265 no 3351 8.91578265047796e-07 1095 3915356
SGTC_2175 5807670 165.306 µM -4.83033364316721 0.00144135217552802 no 3352 6.81522279121719e-07 1095 241186
SGTC_2057 5236571 38.335 µM -4.9047650815562 0.00123665704039017 no 3353 4.67696101762307e-07 1094 54684039 YBR257W POP4
SGTC_1631 benzylvanillin 81.9 µM -5.13123796551357 0.000766376243843449 yes 3354 1.43921364116377e-07 1093 75506
SGTC_2038 4100038 30.985 µM -5.66509570227023 0.000230263084289224 yes 3355 7.34712500186155e-09 1092 3596803
SGTC_2056 5235370 200 µM -12.3362082167062 7.93389923501819e-15 yes 3356 2.8907557372916e-35 1095 5511916