SGTCid condition conc unit YFR054C|YFR054C.score YFR054C|YFR054C.strain.pval YFR054C|YFR054C.strain.significant YFR054C|YFR054C.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene SGTC_2967 9089538 49.85 µM 8.98660331065228 7.09805056191923e-22 yes 1 1.2749449568907e-19 2 728216 SGTC_39 0986-0283 58.349 µM 5.72708065405857 5.34093015611269e-10 yes 2 5.10868000714837e-09 6 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2 SGTC_2616 abietic acid 100 µM 5.68517329416196 7.03734258032756e-10 yes 3 6.53400396418507e-09 12 6708678 Abietic acid is an inhibitor of 5α-reductase. SGTC_1742 st038235 28.8875 µM 5.63578263448982 9.71685005730042e-10 yes 4 8.71325377200416e-09 57 564103 YBR002C RER2 SGTC_1839 st053978 48 µM 5.35012895944476 5.96069608294617e-09 yes 5 4.3945789105998e-08 3 3788398 SGTC_1735 st034310 56.75 µM 4.9867752835428 5.26945026769396e-08 yes 6 3.06977023919944e-07 8 871153 SGTC_3013 9080133 71.4286 µM 4.47342766474575 8.97959280161781e-07 yes 7 3.84878028185905e-06 11 17050193 SGTC_41 0478-0632 82.643 µM 4.36781547378726 1.55353217218258e-06 yes 8 6.27477251467097e-06 21 3750424 SGTC_1302 1159-0335 255 µM 4.16795065354226 4.24236559082319e-06 yes 9 1.53675224171153e-05 12 649284 SGTC_2773 thioridazine 9.09 µM 4.12452981012488 5.24727194420731e-06 yes 10 1.85746438963936e-05 7 5452 An antipsychotic. SGTC_1509 1326-1131 80 µM 4.08668587429294 6.30501605578722e-06 yes 11 2.18789468842312e-05 10 768313 SGTC_3149 9097855 49.47 µM 4.05215545386253 7.44518445850713e-06 yes 12 2.53739632022635e-05 27 25236625 YMR079W SEC14 SGTC_3075 9116269 49.47 µM 3.72632153424171 3.35625010651176e-05 yes 13 9.71472632949459e-05 26 17015205 YNL244C SUI1 SGTC_1519 esterone 74 µM 3.63940841538276 4.92047293478067e-05 yes 14 0.000136632551462863 26 698 A steroid. SGTC_2607 solasodine 47.35 µM 3.55413000409902 7.10643756227046e-05 yes 15 0.000189615850952344 74 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity. SGTC_3043 9092303 49.47 µM 3.52082174124229 8.18649592307437e-05 yes 16 0.000215105861324791 31 25236084 SGTC_2276 7947513 42.08 µM 3.51471992213557 8.40038610242507e-05 yes 17 0.000220109000350266 33 2105100 SGTC_371 0195-0006 7.36 µM 3.48410956564761 9.55505134616005e-05 yes 18 0.00024688865289791 34 3928593 SGTC_976 1348-1067 47.6 µM 3.47057054695812 0.000101119615585263 yes 19 0.000259676948116683 50 5310671 YGL099W LSG1 SGTC_1091 telmisartan 47.6 µM 3.39264514219503 0.000139573357882705 yes 20 0.000346106244148052 36 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension. SGTC_1153 4055-0057 267 µM 3.27713812862103 0.000222411054620666 yes 21 0.000524325274569209 58 882706 SGTC_1414 3917-0015 5.4 µM 3.23122610456074 0.000266621315053478 yes 22 0.000616301966146401 29 6618702 SGTC_1734 st037168 69.4 µM 3.2160783799659 0.000282918902253425 yes 23 0.000649776667654071 58 708907 SGTC_718 1130-0073 349 µM 3.04169635145312 0.000550516294216823 yes 24 0.00117624538447001 62 6740020 SGTC_2980 9014342 25.29 µM 3.00824435565932 0.000623233397081091 yes 25 0.00131380884626141 80 2996599 SGTC_1222 0366-0074 1.18 µM 2.99441760536157 0.000655802439649768 yes 26 0.00137484655506021 53 286520 SGTC_2019 4016004 108 µM 2.94821060375217 0.000776380032853366 yes 27 0.00159809619557183 77 45595336 SGTC_2029 5175081 200 µM 2.92641939436296 0.000840055451656457 yes 28 0.00171444174143073 70 1380876 SGTC_3084 9116877 49.47 µM 2.91631836193902 0.000871171504494579 yes 29 0.00177094443743867 29 27241325 SGTC_1767 st044992 70.3 µM 2.90880180734763 0.000895010043908669 yes 30 0.00181408393978325 68 9600693 SGTC_550 4123-0385 25.7 µM 2.89961022591847 0.000924975332216954 yes 31 0.00186813475495691 81 5731123 SGTC_895 0964-0006 13.7 µM 2.89307836995191 0.000946826973837197 yes 32 0.00190743048486547 55 6738897 SGTC_2835 9006588 71.43 µM 2.89191448490421 0.00095077004158477 yes 33 0.00191451076134964 106 2345538 SGTC_2968 9090663 33.37 µM 2.86632324060441 0.00104137209490887 no 34 0.00207634995370596 89 25236811 SGTC_1233 0325-0408 14.2 µM 2.86572001740505 0.00104360021710891 no 35 0.00208031021047425 71 12874 SGTC_997 3996-0078 137 µM 2.84905238231037 0.00110692187960634 no 36 0.00219248301168478 96 735687 SGTC_2756 carbadox 75.1 µM 2.83234911528462 0.00117389376118385 no 37 0.00231036840215559 134 2553 A substituted quinoxaline antibiotic. YLR208W SEC13 SGTC_199 4063-0024 41.6 µM 2.82338428781556 0.00121134935561447 no 38 0.0023759787875078 34 306215 SGTC_3166 9102297 49.47 µM 2.82163951330296 0.0012187650748461 no 39 0.00238894252768496 88 25237072 SGTC_2360 9040895 200 µM 2.78579424184101 0.00138061068041783 no 40 0.00266983768555991 78 4914414 SGTC_1737 st035557 69.7 µM 2.76366050452662 0.00149011496475857 no 41 0.00285784869214244 63 5716916 SGTC_2919 7978188 46.38 µM 2.73215144572465 0.0016596990603106 no 42 0.00314611051555891 95 2980291 SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM 2.72876096188626 0.00167895726852452 no 43 0.00317863837493415 64 756377 SGTC_1132 3456-3614 2.5 µM 2.70657356982802 0.00181008818225152 no 44 0.00339907588175091 156 3125502 SGTC_3259 9138485 49.47 µM 2.64563331167178 0.00221956923747234 no 45 0.00407690755889124 83 17646153 SGTC_1228 0124-0032 52.5 µM 2.6383167242707 0.00227400069470514 no 46 0.00416593619782236 102 X1228 SGTC_380 3970-0968 6 µM 2.63416748389548 0.00230540335902019 no 47 0.00421719360170013 88 2891601 SGTC_779 1360-0071 233 µM 2.60928964914922 0.0025020623700985 no 48 0.00453652042333098 125 7566 SGTC_273 hydroxyurea 18.1 mM 2.56721662176324 0.00286940933370509 no 49 0.00512592728822924 123 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12 SGTC_416 estradiol valerate 100 µM 2.55886648047814 0.00294785594452971 no 50 0.00525070332044896 91 13791 A steroid. SGTC_1969 st069479 40.1 µM 2.55555629743593 0.00297948526295847 no 51 0.00530091048408844 77 3895485 SGTC_2063 5246145 200 µM 2.54600697614121 0.0030724513572901 no 52 0.00544815053759362 116 711240 SGTC_1219 1469-0211 33.1 µM 2.54432333976116 0.00308911043805656 no 53 0.00547448400139614 82 6822282 SGTC_3030 9087619 49.47 µM 2.52755130145704 0.00325955963509495 no 54 0.00574305208874136 106 25236973 SGTC_1174 0739-0097 51.1 µM 2.51702046989444 0.0033708584178422 no 55 0.00591759764431189 135 728447 SGTC_1263 0774-1208 64.8 µM 2.51482006641087 0.0033945411464666 no 56 0.00595465738294676 172 906585 SGTC_1069 diphenylcyclopropenone 8.49 µM 2.51314401471415 0.00341268053941943 no 57 0.0059830237834877 140 65057 A dermal irritant. YDR527W RBA50 SGTC_2384 9036245 200 µM 2.50783872960502 0.00347067361478582 no 58 0.00607360465083885 118 6462766 SGTC_565 1418-0001 44.5 µM 2.50568939149018 0.00349441931402661 no 59 0.00611064636459406 123 2862145 SGTC_22 0964-0034 14.468 µM 2.49944146962151 0.00356427657794775 no 60 0.00621946225183513 156 138402 SGTC_387 norethindrone acetate 66.7 µM 2.47176770721383 0.00388900394163824 no 61 0.00672234228747191 100 541197 SGTC_992 3909-8734 162 µM 2.44176746466514 0.0042707524567684 no 62 0.00730777868762632 123 4288319 SGTC_2505 galangin 7.89 µM 2.43242698792596 0.00439626718623792 no 63 0.00749900747481544 76 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_817 1391-0715 46 µM 2.42365862761534 0.00451708251082831 no 64 0.00768252062225094 114 1353946 SGTC_2390 9097792 176.6 µM 2.42300616477219 0.00452618991243959 no 65 0.00769633273295018 108 4497149 SGTC_2342 7990637 118.86 µM 2.40719026709395 0.00475203055947873 no 66 0.00803789603752804 145 2033102 YER133W GLC7 SGTC_3176 9106582 49.47 µM 2.40545967326568 0.00477734237177276 no 67 0.00807606726466379 33 17018027 SGTC_1831 st055328 12 µM 2.39864299832726 0.00487821699012653 no 68 0.00822797487026741 142 1103068 SGTC_2970 9090938 41.86 µM 2.39215917132642 0.00497592311648122 no 69 0.00837478832846028 203 17217104 SGTC_564 3555-0129 330 µM 2.38714096415088 0.00505273627409507 no 70 0.00848998958995836 74 563260 SGTC_1617 st002906 78 µM 2.38605521171714 0.005069494055675 no 71 0.0085150970494713 151 5150859 SGTC_1266 0828-0227 32.9 µM 2.37892753703798 0.00518073843668991 no 72 0.00868154441214518 135 3913820 SGTC_1152 3909-8331 15.9 µM 2.37316999623605 0.00527217924053736 no 73 0.00881807241341238 111 16001939 SGTC_3248 9135562 49.47 µM 2.3491571446903 0.00566921620572217 no 74 0.00940798190708273 106 17650701 SGTC_3136 9095672 49.47 µM 2.33311155446968 0.00594910367282678 no 75 0.00982114559432733 141 17217380 SGTC_1827 berberine 7.24 µM 2.32529179828325 0.00608989454167967 no 76 0.0100281812797371 135 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_984 1492-0255 2.91 µM 2.32189102365597 0.00615203956786767 no 77 0.0101194021380307 133 1585198 SGTC_2475 5812728 15.03 µM 2.31146507438052 0.0063460766456808 no 78 0.010403590070753 154 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2 SGTC_2407 paclitaxel 400 µM 2.29457686392083 0.00667189012689073 no 79 0.0108786927139605 181 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_1226 3909-7979 35.4 µM 2.28743558628914 0.00681405244191935 no 80 0.0110852055793283 179 6615510 SGTC_588 3970-1144 52.9 µM 2.28614819950735 0.00683996337568985 no 81 0.0111227950084448 169 1888707 SGTC_968 1309-0633 340 µM 2.27486367589593 0.00707083450829918 no 82 0.0114570544835598 129 3761976 SGTC_2798 7813637 45.45 µM 2.25485059092736 0.00749723611535346 no 83 0.012071354263744 173 956368 SGTC_3224 9130643 49.47 µM 2.24494065548473 0.00771664433446193 no 84 0.0123859712692547 183 17644395 SGTC_1296 1068-0102 11.9 µM 2.23778852167417 0.00787848632611833 no 85 0.0126174246466134 144 767053 SGTC_1295 1013-0063 9.78 µM 2.22473042838608 0.00818168570136466 no 86 0.013049670143261 145 6826038 SGTC_568 1193-0097 7.48 µM 2.19577239645739 0.00889088435037871 no 87 0.014054119172023 324 3646150 SGTC_1525 8-methoxypsoralen 92.5 µM 2.19225762427315 0.00898052705369167 no 88 0.0141804548514212 188 4114 Related to psoralen; DNA damaging agent. SGTC_3204 9114183 49.47 µM 2.18820815580109 0.0090847876495748 no 89 0.0143272216488323 179 17027248 SGTC_2985 9022375 71.43 µM 2.17058294718191 0.00955102255902257 no 90 0.014981356143991 193 4939335 SGTC_2093 5331342 194.4 µM 2.16724424665646 0.00964165914154129 no 91 0.0151081176021168 158 33839 SGTC_1087 pterostilbene 9.05 µM 2.16040183086425 0.00982976360100732 no 92 0.0153707879228472 190 5281727 Similar to reservatol, lowers cholesterol. SGTC_836 0330-0104 1.35 µM 2.15615324756128 0.00994816729513183 no 93 0.0155358504105966 163 46494820 SGTC_1305 1181-0477 144 µM 2.15503814623556 0.00997944957268439 no 94 0.0155794246356188 163 6252086 SGTC_2778 tioconazole 65.09 nM 2.14137736533941 0.0103697049041648 no 95 0.0161218093696674 251 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_2469 5655019 90.81 µM 2.11632875192235 0.011119935279167 no 96 0.0171584285193757 187 2788239 SGTC_989 1501-0895 10.3 µM 2.11436856916386 0.0111805878978006 no 97 0.0172419000010981 136 2830112 SGTC_1647 st011722 22.4 µM 2.11434040745263 0.0111814613784745 no 98 0.0172431017492778 150 2854783 SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM 2.10871833366974 0.0113570315563905 no 99 0.0174844506857763 272 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_1571 st070080 73.4 µM 2.10500267443982 0.0114743773050538 no 100 0.0176455376300079 192 4315245 SGTC_2296 7971656 126.45 µM 2.10124576063475 0.011594095293575 no 101 0.0178096991540075 221 666570 SGTC_608 k048-0125 159 µM 2.08550998784721 0.0121073920881781 no 102 0.0185115162480053 186 6817652 YLR060W | YFL022C FRS1 | FRS2 SGTC_945 3381-0768 11.3 µM 2.07875404226021 0.0123337441982677 no 103 0.0188199814900984 216 1126236 YIL048W NEO1 SGTC_728 3030-5151 22.5 µM 2.07459704812158 0.0124748349598974 no 104 0.0190119479600653 158 3125388 SGTC_1637 st007924 17.4 µM 2.06759197370732 0.0127157539487701 no 105 0.0193392037304521 203 683336 SGTC_1041 0206-0046 107 µM 2.05719299218709 0.0130808172637867 no 106 0.0198338326870153 192 50494 SGTC_911 3456-4043 236 µM 2.04695187970598 0.0134491569887244 no 107 0.0203314047473669 246 914281 SGTC_1378 2093-0007 380 nM 2.02556137115268 0.0142474800275162 no 108 0.0214048767144907 222 3618014 SGTC_1654 st012436 41.8 µM 2.02253792949163 0.0143635481504593 no 109 0.0215604046301105 166 4323132 SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM 2.020431535622 0.0144448917696881 no 110 0.0216693225394567 187 803109 SGTC_3348 9149464 3.537 µM 2.01493347908027 0.0146590837801441 no 111 0.0219558097621798 209 1951442 SGTC_3199 9111318 49.47 µM 2.0076118943788 0.0149485547020502 no 112 0.0223422748098748 221 8548020 SGTC_3293 9120939 62.045 µM 2.00355243734738 0.0151111596366777 no 113 0.0225590125685964 198 934087 SGTC_2767 sibutramine 71.45 µM 2.00353200871757 0.015111981750764 no 114 0.0225601077369359 199 64765 A serotonin-norepinephrine reuptake inhibitor.  SGTC_2628 lathosterol 100 µM 2.00218606021679 0.0151662318168455 no 115 0.0226323621775338 225 6710616 SGTC_866 0495-0101 262 µM 1.99636682699087 0.0154027127168423 no 116 0.022947004443724 202 635694 SGTC_1891 st059073 26.2 µM 1.98988619567221 0.0156697907494573 no 117 0.0233017366774954 223 688754 SGTC_2363 9053361 176 µM 1.98505348196467 0.0158715325461064 no 118 0.0235692607600524 246 6469797 YMR079W SEC14 SGTC_1626 st003712 1.76 µM 1.97888602030959 0.0161322248493057 no 119 0.0239144202816495 217 24207035 SGTC_2199 6590217 200 µM 1.9765336903478 0.0162326175736318 no 120 0.0240471819550079 128 703109 SGTC_249 wiskostatin 11.211 µM 1.97552332488759 0.0162759019713943 no 121 0.0241043951552408 187 2775510 A n-wasp and actin depolymerizer. SGTC_2524 avocatin b 10.57 µM 1.97540602663038 0.0162809334673128 no 122 0.0241110447174803 182 6710748 SGTC_3349 9149703 23.001 µM 1.96515841277636 0.0167256765612121 no 123 0.0246979528048144 198 4910494 SGTC_3153 9100258 49.47 µM 1.96447319536168 0.016755781978319 no 124 0.0247376208966485 255 25236848 SGTC_3054 9094397 49.47 µM 1.96136951878329 0.0168927249287469 no 125 0.024917966524713 269 2598354 SGTC_198 3454-2873 16.191 µM 1.95854085710748 0.017018365941563 no 126 0.0250832908607463 226 710957 SGTC_2395 5646831 180.19 µM 1.95667734002283 0.0171015737695416 no 127 0.0251927078389909 243 6808628 SGTC_1022 4477-0945 21.3 µM 1.95581056775824 0.0171403943025015 no 128 0.0252437367637142 245 4648966 SGTC_1381 2324-0066 62.1 µM 1.94924511145539 0.0174368972407565 no 129 0.0256330800059774 278 10885928 SGTC_908 3448-7491 47.7 µM 1.94536110879186 0.01761435636178 no 130 0.0258657660363111 395 1203031 SGTC_1118 chelidonine 707.474 nM 1.94152689682765 0.017791050195377 no 131 0.0260972001158286 244 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor. SGTC_787 4152-0075 138 µM 1.92907678183708 0.0183752574494464 no 132 0.0268606654587305 239 9566539 SGTC_1404 3909-7820 48.3 µM 1.92388962670407 0.0186234380383798 no 133 0.0271842098803763 211 23741373 SGTC_664 1222-0054 14.9 µM 1.92247408697078 0.018691658401137 no 134 0.0272730655744725 259 6813991 SGTC_1103 duloxetine 36.1 µM 1.91161540027494 0.0192220885043615 no 135 0.0279627712782804 284 60835 A selective serotonin reuptake inhibitor. SGTC_2887 9044784 58.44 µM 1.89722489268338 0.0199447114105829 no 136 0.0288991314096388 281 6465546 SGTC_2678 equilin 100 µM 1.88582296207385 0.0205335087985575 no 137 0.0296594077845227 259 3247 Equilin is an estrone commonly used hormone replacement therapy SGTC_1375 2910-0797 186 µM 1.87214694133533 0.0212591029950141 no 138 0.030593138637116 266 742508 SGTC_2201 6605497 169.863 µM 1.86201460689557 0.0218105658302008 no 139 0.0313005156713965 206 670741 SGTC_12 0849-0099 9.267 µM 1.85681252631323 0.0220983573010923 no 140 0.03166891547394 237 6071388 SGTC_1191 1487-1166 10.6 µM 1.84651567193015 0.0226774609512549 no 141 0.0324086829799165 323 3955771 SGTC_3123 9126162 49.47 µM 1.84329125117257 0.0228614144650257 no 142 0.0326432489146406 248 25239884 SGTC_856 0433-0016 11.3 µM 1.84174777429441 0.0229499139412981 no 143 0.0327560262612327 271 3911780 SGTC_2001 4023502 57.655 µM 1.83294140345665 0.0234603894734868 no 144 0.0334056428153746 291 108941 YCR052W RSC6 SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM 1.82988429754225 0.0236398188165397 no 145 0.0336336209758137 255 689007 SGTC_3048 9093155 49.47 µM 1.82478997765101 0.0239413810202089 no 146 0.0340163644330162 209 25236002 SGTC_741 4582-0002 126 µM 1.81955437473039 0.0242546686823745 no 147 0.0344134475751703 275 2912688 SGTC_1859 st055998 20 µM 1.81573127862652 0.0244856035943662 no 148 0.0347058017570448 282 676301 SGTC_2096 5468907 200 µM 1.81245298590032 0.0246850967063142 no 149 0.0349581160276415 256 759785 SGTC_3288 9119690 36.221 µM 1.81111249461833 0.0247670611680448 no 150 0.0350617199037032 258 17595618 YKL019W RAM2 SGTC_864 0469-0573 172 µM 1.80889793160338 0.0249029708883787 no 151 0.0352334309111987 266 689425 SGTC_1160 4092-0570 10.5 µM 1.80579881115801 0.0250942162403919 no 152 0.0354748856235414 315 4994975 SGTC_887 0885-0007 9.62 µM 1.80423700088318 0.0251910604401946 no 153 0.0355970805754512 307 5719458 SGTC_780 0109-0199 192 µM 1.80181112450242 0.0253421042959362 no 154 0.0357875634447555 322 610414 SGTC_2863 9028737 58.44 µM 1.80169076099142 0.0253496182777181 no 155 0.0357970362459525 215 6460917 SGTC_2060 5238662 140 µM 1.79099906805959 0.0260245587136422 no 156 0.03664672227587 277 790130 SGTC_2525 harmine 47.85 µM 1.78947239255073 0.0261221494880918 no 157 0.0367693848733399 210 5280953 A monoamine oxidase inhibitor SGTC_2829 7992743 58.44 µM 1.78637811984073 0.0263208858073555 no 158 0.0370190279366935 323 16462845 SGTC_1451 4152-0210 104 µM 1.78464695755643 0.0264326237136094 no 159 0.0371592998153292 309 659563 SGTC_1025 k007-0731 70 µM 1.77918726222078 0.0267876194007684 no 160 0.0376045329944898 281 6256118 SGTC_1162 k048-0130 20.1 µM 1.77917871929954 0.0267881779756263 no 161 0.0376052330598507 284 6797406 SGTC_2751 anetholtrithion 17.25 µM 1.77454875176161 0.0270923405152679 no 162 0.0379862127862324 304 2194 A chloretic substance that stimulates the liver to produce bile. SGTC_346 4513-0042 7.16 µM 1.76793403699601 0.0275318850073412 no 163 0.0385359658931863 322 2827372 SGTC_1341 1486-1360 280 µM 1.76242062752107 0.0279027763598031 no 164 0.0389991280066 312 3976547 SGTC_1677 st019204 53.9 µM 1.76202864493167 0.0279293030520649 no 165 0.0390322289263831 299 3945625 SGTC_3272 9137413 49.47 µM 1.76145830767756 0.0279679370783133 no 166 0.0390804318327307 276 17614870 SGTC_1044 1222-0021 1.78 µM 1.75797768448625 0.0282046765412851 no 167 0.0393756531924704 328 4306703 SGTC_1832 st054113 55 µM 1.75406214237467 0.0284729890782144 no 168 0.0397099298275379 251 1251267 SGTC_3028 9087778 49.47 µM 1.75311437421508 0.0285382531443273 no 169 0.0397911883387903 269 17217395 SGTC_1552 6-methylflavone 10.6 µM 1.75118539328985 0.0286714687085688 no 170 0.0399569903386646 240 689013 SGTC_738 1315-0003 72.4 µM 1.74991258396575 0.0287596518882603 no 171 0.0400666994617762 318 6251474 SGTC_3271 9137798 49.47 µM 1.74677317064798 0.0289781221571681 no 172 0.0403383461069372 220 6498326 SGTC_1968 st069590 43.6 µM 1.74353103830033 0.0292051864624606 no 173 0.0406204487403867 273 6384066 SGTC_644 1498-1197 63.3 µM 1.74135100435155 0.0293586956556079 no 174 0.0408110354466654 334 6741615 SGTC_657 3534-0529 86.7 µM 1.72894463600968 0.0302451095047699 no 175 0.0419095021482885 307 1049549 SGTC_2189 6047310 154.431 µM 1.72575046574285 0.0304768841953039 no 176 0.0421961573669943 301 711535 SGTC_3096 9117468 49.47 µM 1.72543885336758 0.0304995739076409 no 177 0.042224207210104 207 41316311 SGTC_2002 4023503 131 µM 1.71770446499316 0.0310672439685201 no 178 0.0429252672695583 421 4736863 YCR052W RSC6 SGTC_1158 4092-0494 91.8 µM 1.71370232672038 0.0313643984186011 no 179 0.0432917046901888 321 1148199 SGTC_1562 morin hydrate 59.1 µM 1.71337368930562 0.0313889034574139 no 180 0.0433219067546986 318 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase. SGTC_47 0149-0135 24.25 µM 1.7126463479286 0.0314431943788278 no 181 0.0433888105558753 299 5239155 SGTC_409 arachidonic acid 100 µM 1.71232014372434 0.0314675684338142 no 182 0.0434188432208092 306 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes. SGTC_1869 3',7'-dimethoxyflavone 40.3 µM 1.71189110826488 0.0314996498439778 no 183 0.0434583688070814 333 688664 SGTC_1323 1348-1351 11.2 µM 1.70549706688988 0.0319809808791067 no 184 0.0440508794259039 276 6989654 SGTC_536 3852-0578 10.6 µM 1.70352078595844 0.0321309744875171 no 185 0.0442353257466574 301 2869208 SGTC_1193 1488-0126 41.5 µM 1.70224217677055 0.0322283260339013 no 186 0.0443549896635116 361 1384710 SGTC_1610 st001799 48.1 µM 1.70079330298734 0.0323389354022663 no 187 0.0444909036394026 254 621897 SGTC_2827 7993847 71.43 µM 1.68728372385995 0.0333854310084891 no 188 0.0457744045638961 272 2985692 SGTC_356 1634-0012 32.5 µM 1.67988408516402 0.0339703510277151 no 189 0.046489935420031 362 735457 SGTC_537 1334-0398 209 µM 1.67982815274458 0.033974804213031 no 190 0.0464953779680827 341 5846986 SGTC_1689 st020265 53.493 µM 1.6765151600993 0.0342394332376535 no 191 0.0468186646292663 307 5758320 YPR016C TIF6 SGTC_1052 3253-3998 198 µM 1.67558730313198 0.0343138498146918 no 192 0.046909528754106 382 5450317 SGTC_662 k832-1615 104 µM 1.67399616574791 0.0344417726266828 no 193 0.0470656764543408 324 5878478 SGTC_2423 st077119 87.2 µM 1.66841946722479 0.0348932197631984 no 194 0.047616243216835 326 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae). SGTC_1385 3091-4834 14.1 µM 1.66077962863639 0.0355195573784064 no 195 0.0483788569844641 316 4072814 SGTC_3202 9113761 49.47 µM 1.65743052117391 0.0357970187883547 no 196 0.0487162325073879 432 4798415 SGTC_2382 9035899 200 µM 1.65333363345137 0.0361388435056772 no 197 0.0491314907696195 351 6462679 SGTC_2243 6634756 200 µM 1.64936990057652 0.0364720977473842 no 198 0.0495359386074549 293 885676 SGTC_1032 k061-1018 98.7 µM 1.64825289187797 0.03656646407573 no 199 0.0496503935959854 409 4005393 SGTC_19 0279-0214 38.434 µM 1.64550672741312 0.0367993130130094 no 200 0.0499326782372791 433 3566274 YBR002C RER2 SGTC_611 3453-1652 23.7 µM 1.64372758681274 0.0369508136375766 no 201 0.0501162424634838 387 1560575 SGTC_3346 9158254 43.5805 µM 1.64143053250673 0.0371471703523364 no 202 0.0503540381157785 360 17639500 SGTC_2739 tacrine 100.86 µM 1.63870947381685 0.0373808742419454 no 203 0.0506368900296832 310 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders. SGTC_1243 0416-0003 5.65 µM 1.63780752078403 0.0374586048973516 no 204 0.0507309261080035 369 2141977 SGTC_2752 diclazuril 33.15 µM 1.63692299713609 0.0375349616362308 no 205 0.050823280039288 522 456389 An antifungal agent for coccidioides. YHR062C RPP1 SGTC_2101 5377231 179.231 µM 1.63607543608054 0.0376082467644697 no 206 0.0509119002153654 301 2844213 SGTC_210 3551-0445 56.827 µM 1.63456108717264 0.0377394771147975 no 207 0.0510705453071516 375 2865180 YOR207C RET1 SGTC_1096 rimcazole 32.2 µM 1.6335996845398 0.0378229840816024 no 208 0.0511714670578896 307 18528119 A dopamine reuptake inhibitor. SGTC_1672 st016598 6.51 µM 1.63178259472833 0.0379812274559938 no 209 0.0513626466029215 393 4665860 YNL267W PIK1 SGTC_2586 curcumin 80 µM 1.62868580892925 0.038252159040722 no 210 0.0516897742217295 438 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40 SGTC_2588 indole-3-carbinol 100 µM 1.62706052885068 0.0383949808902966 no 211 0.0518621215097199 420 3712 Induces cell cycle arrest. SGTC_650 1328-0195 38 µM 1.61603988232321 0.0393749277036533 no 212 0.0530428453194943 382 2780821 SGTC_282 k297-0036 65.7 µM 1.61508607335236 0.039460687890425 no 213 0.0531460282122417 301 5061378 SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM 1.61320575793776 0.0396301984319469 no 214 0.0533499064619008 357 688798 SGTC_724 3910-0327 137 µM 1.61077320557499 0.0398503712240716 no 215 0.053614581593758 373 2885483 SGTC_314 1671-0008 2.74 µM 1.60823126612822 0.0400815060787453 no 216 0.0538922689329958 427 3913060 SGTC_1591 genipin 88.4 µM 1.59443551642866 0.041354999060176 no 217 0.0554192614234203 318 442424 A DNA cross-linking agent. SGTC_833 3852-0053 558 µM 1.59322916999634 0.0414678994949061 no 218 0.0555543948160849 403 3123681 SGTC_1656 st012921 11 µM 1.56969202318099 0.0437211159142852 no 219 0.058243388942532 341 6732821 SGTC_1411 3909-8223 150 µM 1.56530344064018 0.0441519674114367 no 220 0.0587558883918818 392 X1411 SGTC_1192 1488-0095 21.4 µM 1.56242582513559 0.0444363323040262 no 221 0.0590938535984331 373 915875 SGTC_160 3453-0671 289.699 µM 1.56088159984539 0.0445895394365718 no 222 0.0592758447529178 415 5322268 SGTC_1480 1070-0044 41.2 µM 1.55564942540758 0.045111804462197 no 223 0.0598957394530273 388 3124987 SGTC_23 0213-0011 39.996 µM 1.55258543254365 0.0454199242879718 no 224 0.060261104042658 379 627608 SGTC_2670 beta-carotene 100 µM 1.54988871389901 0.0456925087736079 no 225 0.0605841144877231 286 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.) SGTC_882 0843-0131 351 µM 1.54605755845215 0.046082021663593 no 226 0.0610453337833793 411 5425421 SGTC_341 1486-1430 230 µM 1.54343639115182 0.0463500486313703 no 227 0.0613624648943249 395 2054753 YPL210C SRP72 SGTC_3002 9075603 71.4286 µM 1.53843499283346 0.0468649372756286 no 228 0.0619711458888214 405 20105405 SGTC_2897 9048598 12.99 µM 1.53622637979317 0.0470937671702765 no 229 0.0622414341269717 371 6467404 SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM 1.53321099509265 0.047407630459119 no 230 0.0626119380199485 392 4213774 SGTC_1161 k007-0610 110 µM 1.53203223291987 0.0475307793945003 no 231 0.0627572404361919 523 5843850 SGTC_2219 9098279 200 µM 1.53195014387053 0.0475393650274335 no 232 0.0627673690816364 384 902349 SGTC_2566 crystal violet carbinol 226 nM 1.52918397709553 0.0478294033370186 no 233 0.0631094207957856 367 68050 Cationic dye that binds acidic phospholipids including cardiolipin. SGTC_1273 0849-0096 14.1 µM 1.52718340934706 0.0480400485133614 no 234 0.0633577052999512 426 5286025 SGTC_3033 9090887 49.47 µM 1.52666306238868 0.0480949587453565 no 235 0.0634224084582243 444 19325384 SGTC_1331 1472-0049 76.2 µM 1.52081170579135 0.0487158941654586 no 236 0.0641535480159135 405 24051409 SGTC_977 1348-1378 135 µM 1.51429125650826 0.0494153637164526 no 237 0.0649759925848879 408 X977 SGTC_3187 9109394 49.47 µM 1.51366517580626 0.0494829451335823 no 238 0.0650553907888706 436 17098090 SGTC_2452 5863136 48.41 µM 1.51141685323585 0.0497262455549024 no 239 0.065341139065216 413 2184096 SGTC_1994 st072947 40.9 µM 1.50123334824445 0.050840219693147 no 240 0.0666476086805448 422 5286565 YDL195W SEC31 SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM 1.49799977670298 0.0511980672326526 no 241 0.0670666542364755 443 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_104 0074-0074 590.992 µM 1.49566726415566 0.0514574399058009 no 242 0.0673701925271207 276 3943124 SGTC_2335 9018011 154.17 µM 1.49487267857544 0.0515460351462219 no 243 0.0674738369522266 478 6458208 SGTC_1708 st033234 31.827 µM 1.49349569947507 0.0516998536727839 no 244 0.0676537395695762 451 674664 SGTC_2746 daunorubicin 9.88 µM 1.49002811853593 0.052088824172464 no 245 0.0681084213443951 270 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_2703 st077852 53.4 µM 1.48622120889534 0.0525185315991581 no 246 0.0686103097090726 422 6281836 SGTC_2009 4012297 12.05 µM 1.48453621532602 0.0527096224753729 no 247 0.0688333614299292 428 45595307 SGTC_2878 9043973 25.97 µM 1.48082767572868 0.0531321418725353 no 248 0.0693262497988957 385 6465167 SGTC_815 1582-0027 36.9 µM 1.47912690974955 0.0533268086882281 no 249 0.0695531996836899 433 3128206 SGTC_2718 lomofungin 53.02 µM 1.47639715576626 0.0536404330267393 no 250 0.0699186529065295 411 5351222 A RNA synthesis inhibitor. SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM 1.4732175316858 0.0540075835434218 no 251 0.0703461946231395 479 5379071 SGTC_1237 0330-0133 46.1 µM 1.47318657787201 0.0540111675264047 no 252 0.0703503666231332 409 X1237 YHR072W ERG7 SGTC_1094 duloxetine 25.4 µM 1.472223426116 0.0541227800157236 no 253 0.0704802766989512 446 60834 A selective serotonin reuptake inhibitor. SGTC_107 0358-0022 2.6945 µM 1.47012866401817 0.0543661566084594 no 254 0.0707634552073953 298 521106 YGL093W | YPR107C SPC105 | YTH1 SGTC_361 000s-0510 1.45 µM 1.46458289194297 0.0550146644376509 no 255 0.0715173762037176 460 660 SGTC_3133 9127736 49.47 µM 1.46432740760031 0.0550446867445088 no 256 0.0715522560137826 439 27243420 SGTC_3333 9141820 12.094 µM 1.46158305003912 0.0553679968287317 no 257 0.0719277509969709 403 1939433 SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM 1.46043728030361 0.0555034217725763 no 258 0.0720849665991695 488 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis. SGTC_1878 temozolomide 1 mM 1.4596296121666 0.0555990416312306 no 259 0.0721959481432705 403 5394 DNA alkylating agent. SGTC_3106 9121286 49.47 µM 1.45399049697346 0.0562702844644958 no 260 0.0729744704449128 385 15943471 SGTC_48 0382-0018 55 µM 1.4479609099688 0.0569950570995305 no 261 0.073813991613926 408 762596 SGTC_605 1315-0399 119 µM 1.44670913531086 0.0571464411525212 no 262 0.0739892024023176 494 24020461 SGTC_24 0417-1663 219 µM 1.4456612439422 0.0572734116828764 no 263 0.0741361198603423 454 4329390 SGTC_33 0986-0033 35.816 µM 1.44360058914002 0.0575237438162397 no 264 0.0744256795602371 405 2848082 SGTC_457 grayanotoxin iii 135 µM 1.43661098058808 0.0583792694350289 no 265 0.0754142808935349 541 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity. SGTC_1641 st009299 47.1 µM 1.42807416337846 0.059437692638764 no 266 0.0766352565829284 382 4046054 SGTC_670 4204-0025 119 µM 1.42323646469751 0.0600441302724984 no 267 0.0773338090877867 498 719039 SGTC_1901 st060216 58.6 µM 1.41824485864402 0.0606749289837571 no 268 0.0780596446578687 475 688792 SGTC_2433 5607874 27.82 µM 1.41695663642094 0.0608385626293115 no 269 0.0782478030316876 478 2252428 SGTC_1231 0242-0792 125 µM 1.41449044555541 0.0611527876377658 no 270 0.0786089753673803 473 3707635 SGTC_1548 st061468 90.8 µM 1.41350673193843 0.0612784789242863 no 271 0.0787533916986705 461 390799 SGTC_1106 tegaserod maleate 11.7 µM 1.41157094622922 0.0615264079227455 no 272 0.0790381660766549 494 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation. SGTC_1779 st039427 55 µM 1.40676016848232 0.0621459490779228 no 273 0.0797492586885268 564 1124498 SGTC_2052 5265182 7.135 µM 1.40463720083616 0.0624208919234796 no 274 0.0800645942908722 477 1239884 SGTC_3049 9092223 49.47 µM 1.40443449502753 0.0624471936222827 no 275 0.0800947524861705 451 8623917 SGTC_1038 k292-0204 154 µM 1.40264089580121 0.0626802952552179 no 276 0.080361975130961 444 4454212 SGTC_2997 9067075 71.4286 µM 1.40224375759089 0.0627320001372667 no 277 0.0804212344819535 520 27209819 SGTC_1335 1486-0900 202 µM 1.40003092406028 0.0630207058692586 no 278 0.080752029152827 514 X1335 SGTC_2269 7935389 174.42 µM 1.39849873759325 0.0632212140406342 no 279 0.0809816757480604 475 97605 SGTC_2960 9079389 5.97 µM 1.39141149103954 0.064155149292407 no 280 0.0820503410299907 497 16457355 SGTC_94 0334-0113 514.748 µM 1.38891616796861 0.0644865160540379 no 281 0.0824291217488593 474 6795178 SGTC_3032 9089427 49.47 µM 1.38340982568328 0.0652224348385107 no 282 0.0832696197323307 446 17173707 SGTC_1276 0871-0068 94.2 µM 1.3831117665728 0.0652624553724561 no 283 0.0833152991619705 456 3414906 SGTC_1743 st037606 46.3785 µM 1.38297962143175 0.0652802046559867 no 284 0.0833355572605524 472 590142 YLR208W | YDL195W SEC13 | SEC31 SGTC_1035 k081-0041 55.2 µM 1.37259006425793 0.0666874516925627 no 285 0.0849399112136686 530 731709 SGTC_2061 5245884 80.95 µM 1.36633087418957 0.0675465114804592 no 286 0.0859175673223787 522 573863 SGTC_788 1182-0090 188 µM 1.36215336805248 0.0681246062253631 no 287 0.0865747444218873 628 5715185 SGTC_307 1501-1223 22.3 µM 1.36036630630067 0.0683730680056695 no 288 0.0868570176451915 500 2830329 SGTC_885 0865-0106 16.8 µM 1.35617446954035 0.0689586177308997 no 289 0.0875218315416312 508 2793380 SGTC_1873 rapamycin 2 nM 1.35567993629536 0.0690279522805533 no 290 0.0876005129240763 558 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1 SGTC_3195 9113082 49.47 µM 1.35522840606656 0.0690913046331992 no 291 0.0876723985114873 475 17018038 SGTC_932 2857-0803 154 µM 1.34996993626247 0.0698324021520465 no 292 0.0885128132575072 554 674898 SGTC_2339 9000433 200 µM 1.34701758191642 0.0702511628198463 no 293 0.0889872850973742 476 2988954 SGTC_1621 st003705 32.4 µM 1.34525684092676 0.0705018233110703 no 294 0.0892711529698059 559 24207032 SGTC_140 0062-0056 502.533 µM 1.34191450427643 0.0709795315442685 no 295 0.0898118591623045 550 3758964 SGTC_3114 9122766 49.47 µM 1.34148204970222 0.0710415219493754 no 296 0.0898819969448771 490 17176985 SGTC_2168 5727979 200 µM 1.34077555687183 0.0711428839352197 no 297 0.0899966672735065 466 695210 SGTC_1972 st070201 17.4 µM 1.33989679347476 0.0712691168604113 no 298 0.0901394503669706 529 2829099 SGTC_2028 5153890 36.43 µM 1.33763695899991 0.0715945280190725 no 299 0.0905074051687222 515 2830968 YPR165W RHO1 SGTC_235 0330-0087 5 mM 1.33754488489219 0.0716078106165937 no 300 0.0905224206311896 545 46494818 YHR062C RPP1 SGTC_2573 2',4'-dihydroxychalcone 15.04 µM 1.33634833106914 0.0717805972804961 no 301 0.0907177230626254 595 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_872 0588-0139 234 µM 1.33523052436918 0.0719423013173396 no 302 0.090900454688419 543 2047100 SGTC_2665 lovastatin 100 µM 1.33490444730847 0.0719895248299512 no 303 0.0909538110178443 514 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1 SGTC_130 0136-0219 337.655 µM 1.33124506043922 0.0725211200586035 no 304 0.0915541945318162 530 234244 SGTC_2077 5212015 200 µM 1.33094162409321 0.0725653345837008 no 305 0.0916041098823947 515 780900 SGTC_2330 7979373 200 µM 1.32926299710616 0.0728103049724489 no 306 0.0918806088113582 539 1863007 SGTC_98 0074-0023 107.663 µM 1.32650709803877 0.0732138593976307 no 307 0.0923358927963796 560 3563821 SGTC_1409 3909-8004 61.9 µM 1.32371490633263 0.0736244712406878 no 308 0.0927988729796591 548 2119279 SGTC_1131 3454-3128 32.3 µM 1.32182429329872 0.073903497575301 no 309 0.0931133334203247 582 710982 SGTC_1620 st003704 16.5 µM 1.31912374273283 0.0743034591857419 no 310 0.0935638734013138 531 2834414 SGTC_562 3772-2733 112 µM 1.3189526449338 0.0743288549791539 no 311 0.0935924722341317 620 2876874 YIL048W NEO1 SGTC_2406 ethylparaben 405.7 µM 1.31817141684092 0.074444895738627 no 312 0.0937231357882706 461 8434 A possible steroid mimic. SGTC_1422 4031-0024 15.5 µM 1.31652454260335 0.0746899694292115 no 313 0.0939990232592774 527 782427 SGTC_1533 dihydroergotamine mesylate 29.4 µM 1.31647835729429 0.074696851195017 no 314 0.0940067689387073 564 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release. SGTC_1894 3',6'-dihydroxyflavone 78.7 µM 1.31449708750289 0.0749925228508946 no 315 0.0943394887869451 522 688662 SGTC_1410 3909-8106 77.9 µM 1.30169237721409 0.0769249809604261 no 316 0.0965107832250279 522 1039210 SGTC_38 0929-0051 58.268 µM 1.30042913553478 0.077117659382527 no 317 0.0967269647448659 589 1379719 SGTC_2176 5809774 33.9695 µM 1.29584157069977 0.0778204717182693 no 318 0.0975150363816421 563 2870539 SGTC_1537 2',6'-dihydroxyflavanone 78 µM 1.29146974886825 0.0784947458953448 no 319 0.0982704191633699 589 5106787 A p450 inhibitor. SGTC_1755 st041960 45.185 µM 1.28720502081644 0.0791567612221329 no 320 0.0990114188615078 541 2257073 SGTC_1729 st035615 45.989 µM 1.28506137012653 0.0794911134307568 no 321 0.0993854196397334 549 17385451 SGTC_272 doxorubicin 8.13 µM 1.28308046793374 0.0798010303404177 no 322 0.0997319429823315 623 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_2359 9039622 200 µM 1.28292210573273 0.0798258458834449 no 323 0.0997596836681426 581 6463596 SGTC_2603 homopterocarpin 100 µM 1.28156324040138 0.0800390216360344 no 324 0.0999979510974381 593 101795 A weak amylase inhibitor. SGTC_29 0299-0004 12.984 µM 1.28130409206806 0.0800797250700073 no 325 0.100043438069715 453 16871 A napthoquinone isolated from Swertia calycina. SGTC_2709 st078560 56 µM 1.27022074157502 0.0818352273856853 no 326 0.102003005663477 560 17250903 SGTC_428 3448-4153 16.5 µM 1.2694643878285 0.0819560759417881 no 327 0.10213774210662 493 3834874 SGTC_1561 5-methoxyflavone 52.9 µM 1.26913086538709 0.0820094081353326 no 328 0.102197196730089 483 94525 SGTC_2810 7959871 45.46 µM 1.26905525783584 0.0820215018610267 no 329 0.102210678238915 624 2974535 SGTC_2032 5185112 25.99 µM 1.26826251621143 0.0821483849223054 no 330 0.10235210912286 523 5718189 SGTC_519 k048-0011 62.8 µM 1.26528961949678 0.0826255320033738 no 331 0.102883763157897 564 6836379 SGTC_2785 7756463 72.73 µM 1.26440470037551 0.0827679627630727 no 332 0.103042403330116 552 2201551 SGTC_479 n-linoleoylglycine 10 µM 1.26104291239457 0.0833107383882606 no 333 0.103646693375181 532 6433346 An anti-infammatory. SGTC_3011 9081274 71.4286 µM 1.26038770258408 0.0834168358038337 no 334 0.10376476783487 617 6625322 SGTC_1952 st077036 64.1 µM 1.25660161852105 0.0840319020224479 no 335 0.104448964190008 586 2937007 SGTC_1861 st057647 17.4 µM 1.25601599671714 0.0841273421877548 no 336 0.104555085169621 596 688668 SGTC_2473 5854593 8.94 µM 1.24996693162682 0.0851179384675281 no 337 0.105655813699803 546 2872951 SGTC_164 4100-3994 89.624 µM 1.24969258866304 0.0851630712645716 no 338 0.105705932854795 656 4615967 SGTC_182 3448-4371 550.524 µM 1.24501467471601 0.085935407931483 no 339 0.106563178048026 624 3491403 SGTC_109 0132-0036 33.701 µM 1.24214825885788 0.0864112441786053 no 340 0.107090932920915 443 67274 A color developer. SGTC_542 3381-0244 89.3 µM 1.24040690366905 0.0867012763206181 no 341 0.107412464399812 664 1112843 SGTC_425 3825-7017 13.1 µM 1.23694432847005 0.0872801475333255 no 342 0.108053875735962 641 3397440 SGTC_106 0092-0003 11.579 µM 1.23579339926841 0.0874731967344777 no 343 0.108267684589634 499 1072148 SGTC_1352 1496-0991 99 µM 1.22756587412962 0.0888625178546705 no 344 0.109804989490106 599 3000039 SGTC_1318 1280-3875 124 µM 1.2263148588201 0.0890751985730077 no 345 0.110040105938508 630 373245 SGTC_3093 9117344 49.47 µM 1.22624605134027 0.0890869072731155 no 346 0.110053048122421 566 24824913 SGTC_813 k007-0158 173 µM 1.22547760790169 0.0892177481307714 no 347 0.110197660922588 672 6523916 SGTC_2008 4012253 172 µM 1.22544013770098 0.0892241317381348 no 348 0.110204715895259 615 603940 SGTC_3247 9135149 49.47 µM 1.22438804443385 0.0894035102801969 no 349 0.110402938620007 542 8934436 YOR116C RPO31 SGTC_1808 st050063 61.5 µM 1.22394300366213 0.0894794689935888 no 350 0.110486864728891 576 4011993 SGTC_2928 9011484 9.79 µM 1.22272785784367 0.0896871122042347 no 351 0.110716250705719 558 2994751 SGTC_1017 4239-0030 168 µM 1.2213713478164 0.089919334569348 no 352 0.1109727252489 627 1149593 SGTC_1063 disulfiram 1.84 µM 1.22033867681252 0.090096417949822 no 353 0.111168256836612 600 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_2290 7904846 200 µM 1.21992871402207 0.090166790550032 no 354 0.111245949804777 611 2962154 SGTC_2543 pimpinellin 60.67 µM 1.21992719083733 0.0901670520900474 no 355 0.111246238539399 575 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo. SGTC_3119 9125183 49.47 µM 1.21882502179132 0.0903564489429016 no 356 0.11145530617697 468 22695334 SGTC_629 3448-6466 76.7 µM 1.2158447218484 0.0908700633018019 no 357 0.112022039450782 629 573744 SGTC_2879 9041815 71.43 µM 1.21521483988254 0.0909788916791476 no 358 0.112142080960425 486 4942971 SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM 1.21053486641481 0.0917905073894794 no 359 0.1130368600957 666 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_645 0845-0943 5.41 µM 1.2062941394084 0.0925305684349157 no 360 0.113852048293037 596 1885106 SGTC_1942 st076330 65.2 µM 1.2020986592516 0.093267068057681 no 361 0.114662652889382 600 24208414 SGTC_531 3788-1495 174 µM 1.19738001296941 0.0941005723782617 no 362 0.11557923519721 615 2896655 SGTC_1 0258-0098 57.368 µM 1.19726109018764 0.0941216497336946 no 363 0.115602402631664 538 6790032 YDR047W HEM12 SGTC_3254 9136651 49.47 µM 1.19606173320252 0.0943344132613826 no 364 0.115836234669826 648 16454030 SGTC_1765 st044815 90.4 µM 1.19520376211597 0.0944868330964849 no 365 0.116003714520007 616 645695 SGTC_1324 1418-0026 34.4 µM 1.19078251423881 0.0952751537785655 no 366 0.116869487527385 649 1372513 SGTC_1792 st045773 43.6 µM 1.18378379027008 0.0965329288803811 no 367 0.118249330222025 623 2919270 SGTC_1460 k062-0059 9.15 µM 1.1755541171976 0.0980274789308132 no 368 0.11988654982943 623 1373085 SGTC_2110 5483698 200 µM 1.17530559192445 0.0980728746479917 no 369 0.119936239065893 641 2848765 YHR062C RPP1 SGTC_2777 climbazole 1.536 µM 1.17165097970881 0.0987422069873918 no 370 0.120668605734971 674 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2 SGTC_1173 0443-0020 122 µM 1.17062531259971 0.0989306545458759 no 371 0.120874709080932 635 5331295 SGTC_619 1652-1634 108 µM 1.1685304422904 0.0993163658779632 no 372 0.121296433579541 606 5400454 SGTC_1056 3448-1962 115 µM 1.1684331053794 0.0993343144190745 no 373 0.121316053882763 624 715507 SGTC_1784 st039334 36.3 µM 1.16838635158687 0.0993429364763991 no 374 0.121325478887126 642 3496984 SGTC_871 0574-0004 149 µM 1.16812300894454 0.0993915107856189 no 375 0.121378575225869 688 9551173 SGTC_2931 9014674 55.67 µM 1.16804696906179 0.0994055397910005 no 376 0.121393909771564 618 2996810 SGTC_1778 st046819 58.9 µM 1.16778951178976 0.0994530502098829 no 377 0.12144583987928 692 671715 SGTC_3255 9139072 49.47 µM 1.16735748107771 0.0995328131964915 no 378 0.121533017199971 644 17646060 SGTC_937 3122-0005 46.7 µM 1.16542473265712 0.0998902162571171 no 379 0.121923555380065 702 759535 SGTC_2191 5911152 200 µM 1.16242270058074 0.100447208031382 no 380 0.122531903380938 637 2875902 SGTC_1997 st073024 93.8 µM 1.16235963856688 0.100458932700353 no 381 0.122544705406948 643 686268 SGTC_2818 7996756 12.99 µM 1.16221041715879 0.100486680345918 no 382 0.122575002124878 564 2241621 SGTC_2196 6573537 42.6665 µM 1.16132117403014 0.100652150615157 no 383 0.122755655886498 637 2903087 SGTC_725 1497-0963 19 µM 1.16070823182695 0.100766322489793 no 384 0.122880286534639 673 3549977 SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM 1.15782983327768 0.101303740949429 no 385 0.123466743095189 758 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W SGTC_1780 st038448 24.544 µM 1.15569052899 0.101704515658569 no 386 0.123903881748346 652 728868 YDL195W SEC31 SGTC_763 3453-1109 128 µM 1.15408959198804 0.102005187567608 no 387 0.124231719996072 690 1560353 SGTC_2266 7929956 200 µM 1.15224600058779 0.102352233087012 no 388 0.124609999869099 677 2967153 SGTC_3316 9136639 10.545 µM 1.15160143335178 0.102473771535252 no 389 0.124742446064072 640 4903665 SGTC_1768 st044301 37.178 µM 1.15042799483419 0.102695302348144 no 390 0.124983817668005 683 3931349 SGTC_710 3448-4187 58 µM 1.14843299394206 0.103072732635526 no 391 0.125394929825214 749 3946412 SGTC_2125 5246583 200 µM 1.14827105612096 0.103103413484757 no 392 0.125428341912242 752 835267 SGTC_2504 purpurogallin 52.29 µM 1.14734555358314 0.103278887105179 no 393 0.125619416984616 627 5281571 An antioxidant. SGTC_213 1246-0773 967 nM 1.14613373370131 0.103508973668671 no 394 0.125869910773202 698 6251622 SGTC_1829 berberine 14.4 µM 1.14490353727912 0.103742929653194 no 395 0.126124559268093 653 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_2070 5230947 200 µM 1.1427602837864 0.104151444722564 no 396 0.12656906639272 685 2835538 SGTC_2873 9040596 71.43 µM 1.14227598657959 0.104243915555051 no 397 0.126669659768368 671 6463863 SGTC_1367 1812-0510 76.9 µM 1.14015176002681 0.104650214488153 no 398 0.127111540501568 651 1142582 YDR527W RBA50 SGTC_1917 st066507 28.5 µM 1.1396848542581 0.104739672698293 no 399 0.127208809668589 700 3156428 SGTC_874 0599-0792 117 µM 1.13928728133844 0.104815890518113 no 400 0.127291675729666 747 765305 SGTC_1280 0880-0253 10.1 µM 1.13791901536315 0.10507850467293 no 401 0.127577150150518 688 6836607 SGTC_1040 k898-0338 155 µM 1.13571346937929 0.10550282167171 no 402 0.128038250782842 727 20969351 SGTC_497 capsazepine 133 µM 1.13544960588842 0.105553668288994 no 403 0.128093492623145 656 2733484 A calcium channel blocker. SGTC_289 k017-0060 526 µM 1.13404104876001 0.105825397712522 no 404 0.12838866489488 640 5512909 SGTC_1996 st072960 66.8 µM 1.13358192044301 0.105914078849634 no 405 0.128484980172925 716 1719405 SGTC_1048 3161-0300 24.5 µM 1.13084841752492 0.106443169806875 no 406 0.129059448604268 690 2165101 SGTC_1429 4049-0205 9.46 µM 1.13069551896667 0.106472820780517 no 407 0.129091634023417 738 22774478 SGTC_2514 salinomycin 42.74 µM 1.12841409696258 0.106915955859118 no 408 0.129572538524561 762 23682228 A polyether potassium ionophore. SGTC_2659 sanguinarine 24.21 µM 1.12746717347764 0.107100273019546 no 409 0.129772506000153 675 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis. SGTC_1573 oleylamine 1.06 µM 1.1269349888825 0.107203962443003 no 410 0.129884984348476 672 5356789 An amine of the fatty acid oleic acid. SGTC_438 sphingosine 6.67 µM 1.12677001523177 0.107236120160656 no 411 0.129919865581715 579 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes. SGTC_1821 st053465 65.6 µM 1.12331675045489 0.107910849781301 no 412 0.130651496126918 651 675086 SGTC_1291 0993-0025 5.79 µM 1.12285499792589 0.108001302331699 no 413 0.130749541427703 706 4353356 SGTC_705 1124-0212 310 µM 1.12225091869659 0.108119717622566 no 414 0.130877884157523 701 9554485 SGTC_3217 9129673 49.47 µM 1.12137962761709 0.108290677992925 no 415 0.131063152047662 662 17248312 SGTC_344 k064-0035 6.43 µM 1.11768437320973 0.109017904488314 no 416 0.131850909581053 663 5088750 SGTC_303 1348-1668 34.2 µM 1.11657925580886 0.109236072038296 no 417 0.132087132655045 673 5380509 SGTC_318 1488-0629 67.2 µM 1.11599207812777 0.109352117676625 no 418 0.132212762782397 651 3662576 SGTC_892 0929-0076 29 µM 1.11410073722333 0.10972651085424 no 419 0.132617986209631 727 5751038 SGTC_1259 0671-0132 43 µM 1.11338131124169 0.109869163383049 no 420 0.132772348995407 676 X1259 SGTC_1354 1498-1681 81 µM 1.11310264731137 0.109924454452112 no 421 0.132832173426263 738 5754243 SGTC_116 0155-0182 31.788 µM 1.11297070769815 0.109950640198037 no 422 0.132860505102675 813 771486 SGTC_2652 actinonin 100 µM 1.11224908326596 0.110093938499946 no 423 0.133015534678228 664 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase. SGTC_2529 gangaleoidin 93.61 µM 1.11218718726881 0.110106235881925 no 424 0.133028837848695 695 4565183 SGTC_2015 5119600 184 µM 1.11079308255998 0.110383475106411 no 425 0.133328712341047 710 2828786 SGTC_1386 3228-0095 33.8 µM 1.10957204373444 0.110626708392772 no 426 0.133591741814229 679 870181 SGTC_2640 pentamidine 10.38 µM 1.10457673468272 0.111625783592133 no 427 0.134671518375642 760 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_607 4491-0986 66.8 µM 1.10033026487586 0.112480151691673 no 428 0.135594125093116 725 698981 YDR232W HEM1 SGTC_2278 7948257 134.34 µM 1.09786102293004 0.112979093312922 no 429 0.13613259002919 709 1247028 SGTC_1093 fluphenazine 7.97 µM 1.09692764209676 0.11316810554185 no 430 0.136336512038347 734 6602611 An atypical antipsychotic. SGTC_1625 st003711 30.1 µM 1.09347968073707 0.113868283205808 no 431 0.137091622813654 708 24207034 YER133W GLC7 SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM 1.0919289059073 0.114184203545979 no 432 0.137432175595076 624 1241132 A phosphatase inhibitor. SGTC_823 0417-1665 178 µM 1.09186549224084 0.114197135306731 no 433 0.137446113625667 718 3429856 SGTC_2675 theaflavin digallate 100 µM 1.09104724327955 0.114364091956662 no 434 0.137626047535292 728 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative. SGTC_2491 paeonol 100 µM 1.08831227657337 0.114923399362174 no 435 0.138228636357435 694 11092 Increases levels of cortical cytochrome oxidase. SGTC_1776 st049249 45.9 µM 1.08634132962854 0.115327667271157 no 436 0.138664004116399 722 1822314 SGTC_1874 staurosporine 7.6 µM 1.08548025054193 0.115504603144913 no 437 0.138854503070619 749 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1 SGTC_11 0438-0307 1.3 µM 1.08345154315055 0.115922227405452 no 438 0.139304024026155 713 4011476 SGTC_417 st075190 100 µM 1.08002886498635 0.116629238823172 no 439 0.140064663298743 751 222757 SGTC_1406 3909-7906 11.9 µM 1.07923234255453 0.116794211534079 no 440 0.140242082560629 750 X1406 SGTC_2314 7727897 200 µM 1.07809580663955 0.117029892867455 no 441 0.140495501403894 701 900724 SGTC_1764 st044502 93.5 µM 1.07344573216011 0.117997679713414 no 442 0.14153558747552 730 8407 SGTC_654 1124-0271 80.9 µM 1.0733077066433 0.118026492239377 no 443 0.141566539278393 743 5403748 SGTC_1694 st024011 44.9 µM 1.07232459362965 0.118231858901518 no 444 0.141787132043207 766 2787533 SGTC_2569 tetrandrine 100 µM 1.06986178592209 0.118747434224327 no 445 0.142340763107537 648 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_2192 5915882 198.485 µM 1.06930965596883 0.118863237229163 no 446 0.142465080523685 689 2876149 SGTC_2991 9074669 71.4286 µM 1.06848820039904 0.119035675807226 no 447 0.142650175089905 778 17333109 SGTC_136 0097-0015 404.482 µM 1.06579230723784 0.119602833977016 no 448 0.143258769584118 795 4861337 SGTC_593 1203-0218 61.7 µM 1.06399923471742 0.119981111905761 no 449 0.143664523112547 778 3666956 SGTC_1122 capsaicin 818.572 nM 1.06053000332701 0.120715395423468 no 450 0.144451773866636 758 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_377 3970-0964 33.1 µM 1.05907982926925 0.121023269046332 no 451 0.144781712644402 832 16481235 SGTC_794 k038-0031 316 µM 1.0590637421506 0.12102668745545 no 452 0.144785375576006 820 6624242 SGTC_429 1112-0049 25.5 µM 1.05889752078583 0.121062012402322 no 453 0.144823226746378 701 2836170 SGTC_598 3937-0236 20.2 µM 1.05842055227928 0.121163416818396 no 454 0.144931876827662 800 1379313 SGTC_73 0327-0325 16.231 µM 1.05647679758652 0.12157728056099 no 455 0.145375217916293 835 53298 SGTC_2848 9016370 25.97 µM 1.05434665330199 0.122031970269917 no 456 0.145862118289095 809 7894410 SGTC_2246 7293507 91.5585 µM 1.04523939530959 0.12398942170524 no 457 0.147956169985009 781 887656 SGTC_364 0083-0097 67.7 µM 1.04169459860496 0.124757224797022 no 458 0.148776647016377 750 5207356 SGTC_2462 5162487 171.77 µM 1.03920666966411 0.125298090781123 no 459 0.149354314618114 789 2259986 SGTC_2112 5488546 200 µM 1.03814514980242 0.125529358556987 no 460 0.149601242085624 753 600757 SGTC_843 0310-0051 143 µM 1.03788490674388 0.125586101788147 no 461 0.149661820577008 763 2065037 SGTC_2454 5-benzylidenerhodanine 10.36 µM 1.03612138695739 0.125971090105586 no 462 0.150072757891303 835 1273210 SGTC_167 3672-0051 66.205 µM 1.03548510954797 0.126110195588869 no 463 0.15022120844485 696 3237971 SGTC_658 3253-0951 102 µM 1.0348945035951 0.126239411995604 no 464 0.150359090900101 859 1184878 SGTC_3053 9095903 49.47 µM 1.03157831739281 0.126966661198926 no 465 0.151134851079408 786 17174018 SGTC_2177 5811945 192 µM 1.0299256204591 0.127330189133873 no 466 0.15152246135908 761 5343475 SGTC_1824 st053723 68.6 µM 1.02884479824974 0.127568318447633 no 467 0.15177630585291 768 675225 SGTC_3291 9121177 71.43 µM 1.02701855422149 0.127971384112442 no 468 0.152205863693636 682 17015612 SGTC_557 1315-0110 16.2 µM 1.02663416025935 0.12805633531885 no 469 0.152296381198228 787 6833801 SGTC_2317 5986382 200 µM 1.02623004853183 0.128145686389747 no 470 0.152391580387689 818 877883 SGTC_3150 9097574 49.47 µM 1.02489668757395 0.128440806086969 no 471 0.152705968871038 760 17217476 SGTC_3327 9140648 26.9345 µM 1.02146251489227 0.129203080659194 no 472 0.153517680035193 758 8029710 SGTC_1728 st035614 33.7865 µM 1.01950175288631 0.129639709712129 no 473 0.153982410706296 842 15945546 SGTC_339 3091-4833 71.4 µM 1.01661037154599 0.13028543518756 no 474 0.15466940916309 779 3240077 SGTC_1221 2958-7315 257 µM 1.01442928847608 0.130774001409107 no 475 0.15518897735368 759 4562705 SGTC_366 0181-0206 4.31 µM 1.01378608196132 0.130918322221107 no 476 0.155342418965425 813 274874 SGTC_151 3013-0144 2.285 µM 1.01296430513044 0.131102870207391 no 477 0.15553860545593 794 906558 YHR107C CDC12 SGTC_401 neomycin 50 µM 1.01270283743628 0.131161626172555 no 478 0.155601061079438 764 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis. SGTC_251 melphalan 456.522 µM 1.01242272365943 0.13122459238781 no 479 0.155667988960735 881 460612 A DNA alkylator. SGTC_110 0850-0284 111.64 µM 1.00994414554445 0.131782656669065 no 480 0.156261025394797 661 3906265 SGTC_3205 9113483 49.47 µM 1.00742653125768 0.132351184260134 no 481 0.156864923471153 801 17018033 SGTC_1597 7-benzyloxygramine 47.5 µM 1.00347298861214 0.133247380595009 no 482 0.157816351640881 898 260807 SGTC_2091 4-phenylthiadiazole 200 µM 0.999199697763612 0.134220744090338 no 483 0.158848981132571 817 270010 SGTC_3180 9109287 49.47 µM 0.995136857393708 0.135150690011881 no 484 0.159834853382744 758 18891271 SGTC_1201 1889-3372 45.9 µM 0.994850485103248 0.135216404201299 no 485 0.159904493997541 790 5392199 SGTC_196 k015-0023 18.111 µM 0.988471160020005 0.136685956226009 no 486 0.161460976003983 832 5211998 SGTC_102 gallobenzophenone 83.616 µM 0.986425677564894 0.137159460499691 no 487 0.161962134912058 813 70837 SGTC_1661 st013063 9.66 µM 0.985782275722242 0.137308631577858 no 488 0.162119982576475 868 721395 SGTC_3107 9121808 49.47 µM 0.983892069508855 0.137747511781491 no 489 0.162584291699465 783 662681 SGTC_2993 9054257 71.4286 µM 0.981912118649435 0.138208254924539 no 490 0.163071572477342 819 6470217 YGL055W OLE1 SGTC_446 go6976 132 µM 0.979000517149045 0.138887703933807 no 491 0.163789861990918 803 3501 A protein kinase C inhibitor. SGTC_1991 st073000 8.92 µM 0.978389095933937 0.139030673175846 no 492 0.16394095956469 861 4301969 YIL048W NEO1 SGTC_212 3807-4682 38.772 µM 0.978184441131832 0.139078550187107 no 493 0.163991555114985 964 3125501 YBL034C STU1 SGTC_2050 5263056 171 µM 0.974311777260743 0.139986638089594 no 494 0.164950879374353 888 763468 YGL055W OLE1 SGTC_1112 tnp00069 1.16933 µM 0.974209463906092 0.140010683707336 no 495 0.164976273294899 878 145826 SGTC_1136 pergolide 1.05886 µM 0.973726838930205 0.140124147756904 no 496 0.165096093747133 870 47811 A dopamine receptor agonist. SGTC_408 cantharidin 100 µM 0.973238677318462 0.140238976987335 no 497 0.165217346065323 842 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_1474 0330-0125 5.35 µM 0.973163675822199 0.140256625094414 no 498 0.165235980464025 839 X1474 SGTC_2021 4019055 173 µM 0.9730927359361 0.140273318878849 no 499 0.165253606992342 923 44827708 YER133W GLC7 SGTC_834 0312-0008 75.7 µM 0.972830793920584 0.140334971541577 no 500 0.165318702616719 850 6385573 YIL048W NEO1 SGTC_2017 5132927 60.65 µM 0.97054682702027 0.14087332305518 no 501 0.165886997793493 820 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis SGTC_1116 jasmonic acid  1.58368 µM 0.970320096405287 0.14092684184082 no 502 0.165943481573053 842 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid. SGTC_1696 st025591 34.7925 µM 0.969792196698905 0.141051503728282 no 503 0.166075041612085 837 2787147 SGTC_994 3910-0338 138 µM 0.969711753518192 0.141070506701629 no 504 0.166095095100527 858 3479481 SGTC_2411 st077133 39.94 µM 0.967436726767872 0.141608651819259 no 505 0.166662878787742 885 1403142 YNL221C POP1 SGTC_92 0063-0024 660.874 µM 0.967200065015314 0.141664712617398 no 506 0.166722014850924 934 3594437 SGTC_3240 9133527 49.47 µM 0.966042724240507 0.141939081781281 no 507 0.167011401366817 808 17617455 SGTC_1374 2889-5571 141 µM 0.965678088310414 0.142025599995983 no 508 0.167102643584961 849 2853281 SGTC_797 k781-0471 270 µM 0.964077017378813 0.142405913155762 no 509 0.167503657099973 850 23738129 SGTC_3059 1327-0034 3 µM 0.962790541622126 0.142711997122543 no 510 0.16782632413017 818 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_2022 5136654 200 µM 0.959845525605408 0.143414361768864 no 511 0.168566482956384 810 1713771 SGTC_1864 st057645 30.4 µM 0.959471266710449 0.143503786619631 no 512 0.168660693974334 829 688666 SGTC_2881 9058953 51.95 µM 0.958431825985259 0.143752346417099 no 513 0.168922526612049 908 17122249 SGTC_934 2950-0684 338 µM 0.95796597914163 0.143863837841615 no 514 0.169039957011852 891 1121253 SGTC_3310 9130229 44.1445 µM 0.957319537789781 0.144018647679979 no 515 0.169202998405387 830 7761258 SGTC_617 3770-0098 35 µM 0.95623695558948 0.144278156105512 no 516 0.169476266555677 807 5962639 SGTC_3094 9117742 49.47 µM 0.95491457661614 0.144595574221612 no 517 0.169810448832827 919 17149698 SGTC_590 k048-0076 22.4 µM 0.951522074513709 0.145412045949561 no 518 0.170669709084247 848 6832814 SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM 0.951451381432222 0.145429092534774 no 519 0.170687643933052 884 5393153 SGTC_2488 5268135 45.7 µM 0.951040624176022 0.145528167131854 no 520 0.170791876998913 905 1270356 YLR208W SEC13 SGTC_204 PMA1.184 62.41 µM 0.950729782674196 0.145603172226039 no 521 0.170870782683496 898 2252213 YGL008C PMA1 SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM 0.950041229579181 0.145769410506095 no 522 0.171045651765635 848 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1 SGTC_1008 4106-0037 6 µM 0.948045208280837 0.146252033279289 no 523 0.171553219953359 853 2905394 SGTC_3257 9139206 32.98 µM 0.947217311794896 0.14645252684878 no 524 0.171764027810929 829 4910041 SGTC_2248 tofa 1.1 µM 0.946498756043015 0.146626690623259 no 525 0.171947128221443 834 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_1307 1187-1599 12.2 µM 0.945435488314124 0.146884660707875 no 526 0.17221829573794 847 1538471 SGTC_1075 aripiprazole 15.2 µM 0.945067842766972 0.146973929681343 no 527 0.172312120649039 909 60795 An atypical antipschotic. YIL048W NEO1 SGTC_3230 9131665 49.47 µM 0.942885312500749 0.147504624567804 no 528 0.172869784136236 783 15943720 SGTC_1449 4112-4002 201 µM 0.941846617566271 0.147757639587728 no 529 0.173135587018292 804 2059539 SGTC_1804 st050076 49.1 µM 0.941178314114792 0.147920584748702 no 530 0.173306743963205 855 3895976 SGTC_3029 9088683 49.47 µM 0.939306750749655 0.148377547621045 no 531 0.173786636801146 859 25236615 SGTC_653 0203-0016 55.2 µM 0.937155827541754 0.148903884220867 no 532 0.174339203913164 880 295302 SGTC_486 niguldipine 82 µM 0.93644058827463 0.149079181216475 no 533 0.174523194233447 835 1236 A calcium channel blocker. SGTC_1854 st056233 32.9 µM 0.935858195486682 0.149222020831333 no 534 0.174673101778322 840 5393174 SGTC_2838 9002687 71.43 µM 0.934786540877347 0.149485097182073 no 535 0.174949158564486 811 6457060 SGTC_2043 5101342 149 µM 0.933654815264545 0.149763256005912 no 536 0.175240989941709 844 678451 SGTC_1320 1313-0481 95.3 µM 0.930856566308538 0.15045249922302 no 537 0.175963882217753 921 6813365 YLR208W SEC13 SGTC_1100 amiodarone 5.07 µM 0.930538052432918 0.150531086863609 no 538 0.176046285788063 927 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. SGTC_971 1315-0384 26.7 µM 0.930079524578272 0.150644268472377 no 539 0.176164955640258 842 6769120 SGTC_31 0508-1974 57.237 µM 0.929913775237278 0.150685195473163 no 540 0.176207865053956 857 6810525 SGTC_1520 flindersine 88 µM 0.929637624267409 0.150753399402537 no 541 0.176279370080524 904 68230 Flindersine is a natural alkaloid of the quinoline subtype. SGTC_2531 methyl deoxycholate 70.07 µM 0.929455174547132 0.150798472216331 no 542 0.176326622688233 829 16667744 Haematoxylin. SGTC_567 1080-0542 68.4 µM 0.92513486768528 0.151868392626908 no 543 0.177447878998538 830 5950415 SGTC_807 1315-0151 48 µM 0.923440868708468 0.152289283202404 no 544 0.177888751044851 961 4011080 SGTC_2307 7538926 6.34 µM 0.922373882033889 0.152554783551522 no 545 0.178166794165122 885 96582 SGTC_460 trequinsin 123 µM 0.921624482115939 0.152741441671598 no 546 0.178362241898316 945 5537 A vasodilator. SGTC_1450 4112-4260 37.6 µM 0.920164877815538 0.153105429883555 no 547 0.178743302567196 922 1633175 SGTC_1117 retinoic acid 1.10837 µM 0.919912827244256 0.153168343052709 no 548 0.178809157574633 949 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR). SGTC_2437 5741531 144.16 µM 0.91857702060128 0.153502053498184 no 549 0.179158427991465 926 2262990 SGTC_2660 2',4'-dihydroxychalcone 17.14 µM 0.918254065517678 0.15358280617903 no 550 0.1792429347205 870 5357218 A potent inhibitor of glutathione S-transferases. SGTC_2936 9038235 15.59 µM 0.915313795564127 0.154319294035526 no 551 0.180013459410784 875 4749415 SGTC_2365 9042475 200 µM 0.914587448043073 0.154501590917812 no 552 0.180204125318554 872 6464479 SGTC_2402 5553605 200 µM 0.913985542216389 0.154652763546827 no 553 0.180362221337885 929 6758546 SGTC_2748 diazoxide 86.69 µM 0.91249372147958 0.15502786540902 no 554 0.18075443657476 835 3019 A potassium channel activatior. SGTC_3324 9138759 60.749 µM 0.91078200511907 0.155458997119451 no 555 0.181205122867054 892 45595710 SGTC_2882 9058044 58.44 µM 0.907573004116209 0.156269381085036 no 556 0.182051931283703 892 18076804 SGTC_2140 5586273 200 µM 0.907506588011012 0.156286182794244 no 557 0.182069483615399 892 854421 SGTC_2146 5545642 200 µM 0.906774095399226 0.156471565091252 no 558 0.182263135650989 929 825326 SGTC_1368 1852-0141 284 µM 0.904779812396075 0.156977020066492 no 559 0.18279102429488 859 2838987 SGTC_3186 9110464 49.47 µM 0.904293818692169 0.157100358722409 no 560 0.182919811788349 886 17018021 SGTC_522 1273-0010 11.6 µM 0.902162377281495 0.157642042367075 no 561 0.183485308613832 888 5705015 SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM 0.900929683198074 0.157955878113923 no 562 0.183812853858593 895 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_1812 st052057 4.327 µM 0.900009033561917 0.158190536829449 no 563 0.184057721658951 944 3645418 SGTC_686 1319-0111 510 µM 0.899761975638524 0.158253546816931 no 564 0.184123466902199 953 4562600 SGTC_2094 5332512 191.667 µM 0.898657330277516 0.158535478480316 no 565 0.184417605794699 950 755774 SGTC_2738 aclarubicin 5.55 µM 0.896229396770907 0.159156301575187 no 566 0.185065129167144 833 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31 SGTC_699 0375-0592 111 µM 0.896225124523033 0.159157395391502 no 567 0.185066269807634 963 762578 SGTC_2907 7721985 69.9 µM 0.894221914607954 0.159670816250819 no 568 0.185601584609802 909 3267881 SGTC_2593 nobiletin 86.24 µM 0.892924396054895 0.160003946763321 no 569 0.185948830752946 851 72344 An anti-infammatory. SGTC_2625 euphol 100 µM 0.891066794746735 0.160481665908731 no 570 0.186446668732322 927 6708538 A triterpene alcohol. SGTC_2986 9022445 71.43 µM 0.888333053301708 0.161186394924262 no 571 0.187180812491833 935 6459286 SGTC_1608 st001473 40.5 µM 0.887855960234525 0.16130959098093 no 572 0.18730911837426 878 7292267 SGTC_1545 lovastatin 49.4 µM 0.887129918308801 0.161497188995371 no 573 0.187504479029739 979 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12 SGTC_3005 9076496 71.4286 µM 0.883082380031311 0.16254561618883 no 574 0.188595881713633 918 21368410 SGTC_729 4092-0585 94.1 µM 0.881682116068903 0.162909353033861 no 575 0.188974367407512 887 2169061 SGTC_184 1494-0393 24.714 µM 0.881096947241786 0.163061514949242 no 576 0.189132674712027 908 3090647 SGTC_1239 0337-0584 35.4 µM 0.879788322808611 0.163402131786439 no 577 0.189486995841547 987 914301 YML130C ERO1 SGTC_43 0570-0105 72.5 µM 0.879604300662857 0.163450067243956 no 578 0.189536854131162 978 1114046 YDL195W SEC31 SGTC_484 loperamide 105 µM 0.877004627681938 0.164128225162023 no 579 0.19024206225902 874 3955 An opioid-receptor agonist. SGTC_2948 9070189 9.45 µM 0.875928003736 0.164409609920925 no 580 0.190534587308538 848 6473636 YDL196W YDL196W SGTC_388 3',4'-dichloroisocoumarin 16.7 µM 0.875919291341614 0.164411888253598 no 581 0.190536955643125 917 1609 A potent and irreversible inhibitor of serine proteases. SGTC_1126 isoteolin 1.0172 µM 0.872851911821446 0.165215294625841 no 582 0.191371900083321 920 133323 SGTC_1420 4'-methoxyflavone 42 µM 0.870567203318447 0.165815352517569 no 583 0.191995255197796 965 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13 SGTC_3277 9138724 49.47 µM 0.86929438970734 0.166150255714154 no 584 0.192343065362014 843 15943418 SGTC_1555 citronellol 128 µM 0.869108448267904 0.166199217250687 no 585 0.192393908120115 914 8842 A terpine precursor. SGTC_1240 0356-0016 42.1 µM 0.868751851942973 0.166293141186882 no 586 0.192491436758523 918 4305613 SGTC_2283 7944793 200 µM 0.867424114760432 0.166643155360822 no 587 0.192854836876646 981 2970533 SGTC_1271 0832-2808 169 µM 0.866958820933579 0.166765927172771 no 588 0.192982286354678 987 3663794 SGTC_3179 9107801 49.47 µM 0.865435499616184 0.167168276883861 no 589 0.193399901786584 958 4818259 SGTC_841 0251-0215 91.2 µM 0.863556505864824 0.167665430456842 no 590 0.193915782949301 987 3888614 SGTC_516 3992-2719 87.3 µM 0.861669911473105 0.168165552039287 no 591 0.194434593728021 985 5350887 YDR037W KRS1 SGTC_27 0485-0001 32.618 µM 0.861509305073351 0.168208171840688 no 592 0.194478799253394 908 2054479 SGTC_2142 5622915 118.518 µM 0.859895003411612 0.168636941762126 no 593 0.194923461533995 926 5322196 SGTC_2285 7945142 200 µM 0.859496045794694 0.168743015892877 no 594 0.195033450324439 908 2970608 SGTC_2841 9004761 38.96 µM 0.859304695785735 0.168793906898822 no 595 0.195086217072799 919 2991039 SGTC_504 lovastatin 124 µM 0.858272757084378 0.169068528916847 no 596 0.195370934431176 918 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1 SGTC_675 1309-0189 238 µM 0.856996384433072 0.169408596996707 no 597 0.195723441398709 915 4246530 SGTC_2375 9072683 200 µM 0.856820204087619 0.169455571749408 no 598 0.195772128966429 1060 16798029 SGTC_2831 7999036 19.48 µM 0.856630473067894 0.169506168848742 no 599 0.19582456949283 986 2988270 SGTC_1065 prochlorperazine maleate 2.48 µM 0.856385201041286 0.16957159187982 no 600 0.19589237385529 983 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine. SGTC_2594 a-mangostin 100 µM 0.852533012413534 0.170601236354304 no 601 0.196959162190508 968 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis. SGTC_3304 9125678 46.087 µM 0.850345566047951 0.17118769290775 no 602 0.197566495092953 935 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2 SGTC_3099 9120367 49.47 µM 0.846049812890585 0.172343135347964 no 603 0.198762478148356 983 24824940 SGTC_2642 cholecalciferol 100 µM 0.843217566818539 0.173107648600986 no 604 0.199553387749424 982 9821465 A vitamin D precursor, similar to steriods. SGTC_3151 9099821 49.47 µM 0.842529865887247 0.173293606382323 no 605 0.199745714828742 969 17174189 SGTC_1264 0783-0040 158 µM 0.842289520312977 0.173358627013804 no 606 0.19981295778014 925 2855798 SGTC_323 4013-0906 34.3 µM 0.842234399544358 0.173373541011445 no 607 0.199828381173918 1014 2910086 SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM 0.84181063259111 0.173488226691925 no 608 0.199946979713348 1017 23847180 SGTC_951 1171-0579 82.7 µM 0.841163227483417 0.173663529632851 no 609 0.200128248976218 1016 1616050 YPR165W | YDR526C RHO1 | YDR526C SGTC_2129 girgensonine 121.053 µM 0.840387588757844 0.17387370373121 no 610 0.200345552839995 1021 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_3108 9121785 49.47 µM 0.840067658710948 0.173960441977899 no 611 0.200435226098589 988 17140271 SGTC_3060 1327-0027 12.5 µM 0.839953047244537 0.173991521705571 no 612 0.200467356434419 945 16000455 YPR107C YTH1 SGTC_2323 6148992 148.28 µM 0.837826378619057 0.174568860809197 no 613 0.201064110718656 878 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42 SGTC_711 k292-0785 179 µM 0.83759477312899 0.174631809476562 no 614 0.201129164700298 1025 4146315 SGTC_782 0083-0095 30.5 µM 0.834380741756223 0.175506846942884 no 615 0.20203323297208 1044 3591729 An indicator and reagent. SGTC_2286 7945697 125 µM 0.832970247296109 0.175891737586722 no 616 0.202430754714002 1003 1245733 SGTC_1927 st060202 13.8 µM 0.83261246787568 0.175989452075948 no 617 0.202531662530787 996 688887 SGTC_350 k064-0020 19.8 µM 0.829633561128071 0.17680436658775 no 618 0.203372997827641 1033 2790705 SGTC_757 1066-0008 322 µM 0.82708872761626 0.177502421383694 no 619 0.204093386434712 1018 6842497 SGTC_1966 st070145 16.1 µM 0.826403491454537 0.17769068041023 no 620 0.204287621759101 1001 3748532 SGTC_10 0279-0212 42.575 µM 0.826293666130499 0.177720865087535 no 621 0.204318762800868 1084 39851 YBR002C RER2 SGTC_293 4049-0273 38.5 µM 0.825954128198001 0.177814205034347 no 622 0.204415056875805 953 1380311 SGTC_1169 aniline yellow 25.8 µM 0.825931410934832 0.17782045117833 no 623 0.204421500530414 975 6051 A DNA damaging agent. SGTC_768 0384-0033 77.3 µM 0.825356912596481 0.177978456321791 no 624 0.204584494715595 981 3965305 YMR134W ERG29 SGTC_2745 rifampicin 24.3 µM 0.824754171938707 0.178144324128342 no 625 0.204755584787763 889 25141428 Inhibits bacterial DNA-dependent RNA polymerase. SGTC_1923 st058458 19.1 µM 0.824573971107902 0.178193932391581 no 626 0.204806751952192 1064 3534982 SGTC_2302 7771753 200 µM 0.822311445095238 0.178817533736865 no 627 0.205449832267872 1018 2203047 SGTC_1649 st011737 51.3 µM 0.820583901115442 0.179294606129942 no 628 0.205941660385227 984 1761035 SGTC_1700 st030840 7.9285 µM 0.820036929896504 0.179445822428332 no 629 0.206097527381977 1023 5499307 SGTC_2216 7189485 200 µM 0.81936303253735 0.179632239079872 no 630 0.206289659883129 1031 731273 SGTC_826 1683-5028 118 µM 0.819292742335845 0.179651690091624 no 631 0.206309706186799 984 722377 SGTC_2376 9072922 81.32 µM 0.81803781977199 0.17999918046515 no 632 0.206667796122362 1026 17087968 SGTC_453 enantio-paf c16 10 µM 0.81779653795771 0.180066040186751 no 633 0.206736687623135 1062 13871343 A lipid and platelet activating factor SGTC_2994 9053520 71.4286 µM 0.815407258730129 0.180728956149068 no 634 0.207419615378406 1018 4647384 SGTC_2651 TUB2.036 5 µM 0.815286701262414 0.180762445846432 no 635 0.207454109629232 1156 15992207 YFL037W TUB2 SGTC_325 2810-4341 181 µM 0.814472334022403 0.18098877107155 no 636 0.207687207535165 1041 774970 SGTC_1517 deoxycholic acid methyl ester 49.2 µM 0.813934772737737 0.181138264896144 no 637 0.207841159482134 1020 229346 A bile salt which induces apoptosis. SGTC_3307 9126885 69.2785 µM 0.81393202718643 0.181139028622392 no 638 0.207841945952349 1003 24824909 SGTC_3007 9078383 71.4286 µM 0.812387849536148 0.181568889971388 no 639 0.208284558011274 1020 6496995 SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM 0.809172203461991 0.18246609430313 no 640 0.209208050592387 974 279621 SGTC_2141 5621638 7.665 µM 0.808492565788454 0.182656075399107 no 641 0.209403541988745 1032 2856238 SGTC_2959 9079155 11 µM 0.807128602971197 0.183037720401326 no 642 0.209796197257311 996 16189457 SGTC_2442 5158906 48.48 µM 0.806877384701318 0.183108067002099 no 643 0.209868564714515 1033 1893835 SGTC_1904 st060225 78 µM 0.804017726313839 0.183910022084936 no 644 0.210693368825175 1005 66595 SGTC_1862 st057513 3.81 µM 0.803978137936036 0.183921139473407 no 645 0.21070480053108 1051 5393163 SGTC_414 piperonyl butoxide 100 µM 0.803888883076241 0.183946205964861 no 646 0.210730575473416 1016 5794 A potent inhibitor of cytochrome P450. SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM 0.801711907688442 0.184558250144377 no 647 0.211359813065217 1103 66535 A nucleotide analog. SGTC_1932 st074806 40.9 µM 0.80161442181923 0.184585687332829 no 648 0.211388016308691 1162 17251235 SGTC_3317 9138495 8.753 µM 0.800673042257547 0.184850767084882 no 649 0.211660476422502 1073 17020139 SGTC_1955 wogonin 32.4 µM 0.80057008009809 0.184879774183297 no 650 0.211690288856696 1012 5281703 A flavanone. SGTC_1179 1021-1431 9.29 µM 0.799494640575393 0.185182922323026 no 651 0.212001826531085 1055 2840958 SGTC_2786 7743617 45.45 µM 0.797862749339954 0.185643514009743 no 652 0.212475071181491 954 583674 SGTC_155 k072-0202 43.6 µM 0.797583811741704 0.185722313575782 no 653 0.212556024149492 1017 5857737 SGTC_1496 4469-0713 57.4 µM 0.796591586184378 0.186002784354083 no 654 0.212844132754477 1034 746691 SGTC_2803 7707263 71.43 µM 0.794771487950518 0.186517950770966 no 655 0.213373219614595 1001 2199229 SGTC_3164 9100705 49.47 µM 0.792083939318786 0.187280257020643 no 656 0.214155867076766 1026 17174235 SGTC_2000 st075254 36.4 µM 0.792036410909035 0.187293755466197 no 657 0.214169722953264 1012 17234175 SGTC_69 0096-0274 206.684 µM 0.7907795459222 0.187650933349957 no 658 0.214536323908781 1202 6741392 SGTC_1521 st012942 49.4 µM 0.789925577946873 0.187893855249599 no 659 0.214785616323258 1079 24207259 SGTC_713 1488-1073 324 µM 0.789780051487112 0.187935271432352 no 660 0.214828115540423 1058 3312542 SGTC_2244 6635614 200 µM 0.788724541333299 0.188235833596219 no 661 0.21513651051387 899 836499 SGTC_2619 obliquin 87.91 µM 0.787347679735556 0.188628347802781 no 662 0.215539182767562 1077 6708593 A bioactive alkalod. YER133W GLC7 SGTC_1405 3909-7894 12 µM 0.787247570207136 0.188656906582558 no 663 0.215568477495392 1077 7104060 SGTC_383 2324-0395 7.37 µM 0.784204263921305 0.18952635857992 no 664 0.216460131801434 1080 3146421 SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM 0.784068725080846 0.189565138370497 no 665 0.216499892728187 1055 6708514 SGTC_2661 dactinomycin 12.96 µM 0.783981292188475 0.189590156884104 no 666 0.216525543801476 1082 45006140 An Actinomycin D Classic transcription inhibitor. SGTC_1497 4476-2978 41.3 µM 0.779844377818067 0.190776236553519 no 667 0.217741240756297 1102 1528379 SGTC_2320 7373003 200 µM 0.778212235798737 0.191245431901292 no 668 0.218221952317388 1093 5415828 SGTC_459 nigericin 15.3 µM 0.777729781011118 0.1913842595471 no 669 0.218364165786159 1142 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification. SGTC_2663 amphotericin b 100 µM 0.777672189035481 0.191400835916134 no 670 0.218381145771233 1069 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_2783 7738165 71.43 µM 0.776977746621134 0.191600782563542 no 671 0.218585949817081 994 17201110 SGTC_476 mead acid 10 µM 0.775781455122277 0.191945523517899 no 672 0.218939017732626 1080 5312531 An omega 9 fatty acid. SGTC_1557 sumaresinolic acid 42.3 µM 0.775523854487535 0.19201980715401 no 673 0.21901508768961 1037 9982268 A natural terpine and antifungal of unknown mechanisn. SGTC_579 4491-1009 110 µM 0.774385159167822 0.192348380527476 no 674 0.219351528632955 1246 1271041 SGTC_510 ag-490 170 µM 0.774085537318725 0.19243489426348 no 675 0.219440104767064 1181 5328779 SGTC_1238 0333-0287 48.8 µM 0.773804760024094 0.192515988354956 no 676 0.21952312860148 1090 7226 SGTC_2496 diffractaic acid 79.83 µM 0.771076878878817 0.193304941904721 no 677 0.22033068216185 1075 94870 An apoptosis inducer which activates caspases. SGTC_1360 1598-0022 39.8 µM 0.770164330930653 0.193569307411521 no 678 0.220601209734258 1113 761525 SGTC_1389 3405-0187 19 µM 0.769712350033749 0.19370032807466 no 679 0.220735271261717 1041 799890 SGTC_299 1273-0059 1.44 µM 0.766997955717989 0.19448831625197 no 680 0.221541365486545 1056 2848077 SGTC_2443 5493264 126.67 µM 0.766366555292929 0.194671891013366 no 681 0.221729113529857 1087 5340055 SGTC_3081 9117243 49.47 µM 0.766217756618951 0.194715168415039 no 682 0.221773372313104 1094 45595589 SGTC_1390 3413-2614 145 µM 0.764285230951023 0.195277766003027 no 683 0.222348642338848 1148 3421432 SGTC_2298 7976326 193.81 µM 0.76344704931952 0.1955220845291 no 684 0.222598414846854 1014 2235818 SGTC_1055 3448-0672 86 µM 0.762568688608374 0.195778313801365 no 685 0.222860332012291 1051 748378 SGTC_1345 1488-0192 31.4 µM 0.761160874545029 0.19618941636737 no 686 0.223280492154744 1128 658348 SGTC_2282 7944268 200 µM 0.75925344378577 0.196747248749697 no 687 0.223850480779281 1099 2970414 SGTC_2695 st077686 51.995 µM 0.757526427388986 0.197253146241037 no 688 0.224367269609703 1106 2876092 SGTC_2071 5230951 39.92 µM 0.757409561118332 0.197287408455746 no 689 0.224402264878692 1169 1799272 SGTC_2257 7960413 200 µM 0.755118777878611 0.197959734416729 no 690 0.22508885856838 1114 2974689 YIL048W NEO1 SGTC_1912 st060209 90.8 µM 0.754279690814557 0.19820634541353 no 691 0.225340647322664 1073 688787 SGTC_1396 3511-0007 98.6 µM 0.752862042524114 0.198623418954469 no 692 0.225766409767399 1050 X1396 SGTC_1722 st034304 3.6505 µM 0.751703807440131 0.198964565429521 no 693 0.22611460010907 1139 4036148 YLR033W RSC58 SGTC_1702 st027038 51 µM 0.751077287352706 0.199149247681386 no 694 0.226303071913875 1124 5521182 SGTC_1105 epirubicin 18.1 µM 0.749105496066042 0.199731155363648 no 695 0.226896811335595 1095 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_1156 4092-0367 4.88 µM 0.746596695918763 0.200473020012016 no 696 0.22765352172931 1122 1357585 SGTC_2387 9077560 195.08 µM 0.746042754569113 0.200637045989572 no 697 0.227820794143995 1107 5303272 SGTC_309 k408-0051 1.48 µM 0.745994272886082 0.200651405594641 no 698 0.227835437338849 1116 3640463 SGTC_863 0466-0191 129 µM 0.7458274523743 0.200700820240613 no 699 0.2278858271207 1144 765160 YPR165W RHO1 SGTC_2859 9028643 45.46 µM 0.744239977902132 0.201171418536373 no 700 0.228365653079272 1092 17151580 SGTC_3252 9135871 49.47 µM 0.744161838649234 0.201194599572607 no 701 0.228389285901053 1170 17682838 SGTC_3167 9103034 49.47 µM 0.743749633995334 0.201316912008574 no 702 0.228513977858279 1137 5127859 SGTC_2708 st078559 56 µM 0.741918225373083 0.201860879955924 no 703 0.229068441352585 1049 17250902 SGTC_1023 4482-3888 16 µM 0.741424496255429 0.202007678638983 no 704 0.22921804811689 1115 3303168 SGTC_1589 2',5'-dimethoxyflavone 47.2 µM 0.741373474708957 0.202022852331618 no 705 0.229233511475462 1106 688667 SGTC_1357 1503-1303 39.5 µM 0.741281032684361 0.2020503461184 no 706 0.229261529838135 1166 292895 SGTC_2329 6138490 200 µM 0.740978999416904 0.202140191415716 no 707 0.229353086843083 1014 720019 SGTC_1303 1160-0052 261 µM 0.740596965169541 0.202253868695886 no 708 0.22946892433812 1157 3562476 SGTC_756 0508-1999 28.3 µM 0.737638376984153 0.20313551385532 no 709 0.230367114048361 1134 6753853 SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM 0.736254225952453 0.203548770817892 no 710 0.230787998679939 1218 6710655 SGTC_1500 4488-1866 171 µM 0.735229914471883 0.203854915417661 no 711 0.231099741698323 1185 2900003 SGTC_1483 3453-0561 55.9 µM 0.733806885409564 0.204280683259927 no 712 0.231533221763396 1130 4546991 SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM 0.733434586427046 0.204392161796498 no 713 0.231646705441344 1187 91467 include heat shock SGTC_2113 5491891 107.031 µM 0.732543450816256 0.204659144089558 no 714 0.231918466064619 1176 789979 SGTC_173 1273-0061 2.693 µM 0.730143200600526 0.205379285063868 no 715 0.232651328559886 1124 2847414 YPL266W DIM1 SGTC_1526 st051518 75 µM 0.729150138922644 0.205677670440803 no 716 0.232954913697664 1052 673993 SGTC_1495 4469-0029 237 µM 0.728326403042639 0.205925373592915 no 717 0.233206901747296 1183 793680 SGTC_1444 4112-3581 28 µM 0.727120456200048 0.206288329253404 no 718 0.2335760842253 1163 2877249 SGTC_1383 3049-0032 20.7 µM 0.726872744311731 0.206362930391489 no 719 0.233651957595369 1177 712864 SGTC_348 k064-0012 10.7 µM 0.726066284636525 0.206605915246359 no 720 0.233899068285108 1109 5066323 SGTC_1544 7-methoxy-4-methylcoumarin 105 µM 0.724978248252954 0.206934007040431 no 721 0.234232687421298 1131 390807 SGTC_2685 mycophenolic acid 18.85 µM 0.723935346209878 0.207248778038575 no 722 0.234552714352383 1126 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_3170 9103054 49.47 µM 0.72305931180658 0.207513403366538 no 723 0.234821722756814 1123 16432970 SGTC_3321 9137793 26.8275 µM 0.722957184000798 0.207544266293143 no 724 0.234853094764806 1161 4904192 SGTC_2713 st079149 53.4 µM 0.721979286107647 0.207839923431159 no 725 0.23515360641821 1146 3103253 SGTC_345 1362-0200 395 µM 0.720832369565213 0.208186998323031 no 726 0.235506328558563 1131 1419823 SGTC_28 pentachloropyridine N-oxide 1.606 µM 0.719770384046793 0.208508676510771 no 727 0.235833191182728 1112 140250 A respiratory chain inhibitor. SGTC_1314 1222-0010 41.1 µM 0.71905641945227 0.208725102905723 no 728 0.236053078893143 1162 3526027 SGTC_1194 1488-0194 225 µM 0.71877017221628 0.208811911123193 no 729 0.236141269389008 1147 1391452 SGTC_232 clozapine 119 µM 0.71816094770165 0.208996737227893 no 730 0.236329027021041 1120 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_276 colchicine 750 µM 0.717562182033621 0.20917848418891 no 731 0.236513641390977 1210 2833 A microtubule depolymerizer. SGTC_423 5-fluorouracil 457 µM 0.71551291220477 0.20980121523073 no 732 0.237146082546214 1144 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_974 1326-0144 138 µM 0.714202056123452 0.210200128402926 no 733 0.237551122826801 1191 5411856 SGTC_2476 5806916 10.51 µM 0.710773879811261 0.211245477478561 no 734 0.238612184627806 1095 2870194 SGTC_1939 st074455 53.6 µM 0.709127213654436 0.211748674072463 no 735 0.239122768303391 1181 1644229 SGTC_3343 9148379 18.9835 µM 0.709091109226798 0.211759714899195 no 736 0.239133969930803 1210 1955036 SGTC_278 4092-0821 23.9 µM 0.707575961540015 0.212223354587838 no 737 0.239604312554955 1182 877900 SGTC_3308 9128332 17.569 µM 0.706601007570814 0.212522006896609 no 738 0.2399072313127 1192 17332805 YDL196W YDL196W SGTC_3301 9125354 19.7965 µM 0.706498095141307 0.212553545815672 no 739 0.239939218446716 1152 41905162 SGTC_1837 st055472 66.5 µM 0.705453957054026 0.212873690731233 no 740 0.240263887834597 1235 676091 SGTC_1852 st056254 31.4 µM 0.703939480759746 0.213338546620133 no 741 0.240735231587302 1145 442583 SGTC_687 k029-0044 34.9 µM 0.702552995693401 0.213764635111659 no 742 0.241167182038238 1203 5829338 SGTC_750 4073-0104 132 µM 0.699064538061802 0.214838882305366 no 743 0.242255849508543 1047 22330957 SGTC_918 glabranin 770.725 nM 0.697592252491541 0.215293202242208 no 744 0.242716114056628 1206 124049 Also referred to as licorice root. SGTC_786 4544-0069 423 µM 0.697356006479155 0.215366155239499 no 745 0.242790013113998 1186 748821 YLR208W SEC13 SGTC_2638 epoxomicin 18 µM 0.697221017286985 0.215407846470927 no 746 0.242832243945105 1182 9915668 A protesome inhibitor. SGTC_3188 9110789 49.47 µM 0.694175043810079 0.216349835390785 no 747 0.243786220617148 1222 849217 SGTC_2741 miltefosine 3.04 µM 0.69383184784259 0.216456120438566 no 748 0.243893833749768 1107 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis. SGTC_3239 9133757 49.47 µM 0.692862265116615 0.216756555671319 no 749 0.244197996273359 1190 17036923 SGTC_2398 5228213 48.84 µM 0.692395295260403 0.216901337100862 no 750 0.244344559784309 1224 80771 YMR134W ERG29 SGTC_991 3996-0057 64.7 µM 0.689564973241296 0.217780058242182 no 751 0.245233900386088 1180 715343 SGTC_869 0564-0080 44.1 µM 0.689468323245681 0.217810101075694 no 752 0.245264300337885 1187 6843321 SGTC_499 genistein 192 µM 0.689418934385674 0.217825454107866 no 753 0.245279835719399 1219 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger. SGTC_3134 9127454 49.47 µM 0.688434718886928 0.218131537694324 no 754 0.245589533287721 1297 24262820 SGTC_1518 st038567 90.8 µM 0.686671290906001 0.218680569988674 no 755 0.246144946154522 1208 77966 SGTC_2812 7970281 58.44 µM 0.686246474643247 0.218812952670808 no 756 0.24627884776987 1234 2233435 SGTC_958 1222-0007 33 µM 0.685929096390417 0.218911885243887 no 757 0.246378910523853 1263 7312461 SGTC_904 1141-0088 396 µM 0.685399082564727 0.219077157545554 no 758 0.246546061412816 1175 1378119 SGTC_1900 st060200 72.8 µM 0.685264541730956 0.219119122344569 no 759 0.246588501330316 1228 688945 SGTC_2078 5212016 200 µM 0.683724601653125 0.219599776068137 no 760 0.247074542722363 1152 1899708 SGTC_1540 guanosine 70.6 µM 0.682826952430766 0.219880233916349 no 761 0.247358098237945 1166 6802 Guanosine is a purine nucleoside SGTC_924 2046-0044 21.3 µM 0.68272753342958 0.219911308621521 no 762 0.24738951408155 1235 3623589 SGTC_1899 st063254 59.6 µM 0.681781144695658 0.220207240914269 no 763 0.247688674325782 1164 3093813 SGTC_304 1310-0298 97 µM 0.681406211715834 0.220324544213338 no 764 0.247807246730244 1167 1550234 SGTC_2506 ethyl hematommate 54.16 µM 0.681146473739539 0.220405828060851 no 765 0.247889406525786 1194 3940691 An allergen. SGTC_925 2064-1272 59.6 µM 0.680113417290841 0.220729288575606 no 766 0.248216324728365 1195 6815817 SGTC_1124 fisetin 1.16336 µM 0.679406693800747 0.220950727437273 no 767 0.248440104873585 1207 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster. SGTC_1432 4049-0298 68.4 µM 0.676665451679879 0.221810847681937 no 768 0.249309120637255 1233 741646 SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM 0.676604162985159 0.221830100084871 no 769 0.249328568545829 1216 6312947 SGTC_1885 st057546 99.9 µM 0.675646604331577 0.222131018554067 no 770 0.249632522327243 1271 702008 SGTC_1334 1486-0610 236 µM 0.674900750335989 0.222365568910664 no 771 0.249869411889197 1225 3742339 SGTC_2085 5307070 144.047 µM 0.671365149797408 0.223479337270925 no 772 0.250993970222832 1199 2840351 SGTC_2109 5483026 200 µM 0.669202620032723 0.224162128469068 no 773 0.251683117579867 1258 759335 SGTC_310 1273-0058 1.06 µM 0.668927645375274 0.22424903302901 no 774 0.251770817091245 1254 2734232 SGTC_2277 7947813 106.88 µM 0.667543407935784 0.224686805754955 no 775 0.252212546167657 1306 1246798 SGTC_3144 9087057 49.47 µM 0.665871200572543 0.225216296423787 no 776 0.252746714967899 1186 17249618 SGTC_2612 dictamnine 15.46 µM 0.664035781775564 0.225798279401278 no 777 0.253333704964119 1215 68085 A quinoline derivative and established mutagen. YOR116C RPO31 SGTC_2683 piperine 63.03 µM 0.662883391256285 0.226164118917619 no 778 0.253702619829607 1212 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_1584 6-fluoro-dl-tryptophan 90 µM 0.662686195620569 0.226226754466124 no 779 0.253765776339859 1306 94937 An inhibitor of serotonin biosynthesis. SGTC_956 1185-0240 191 µM 0.662266311188712 0.226360155640836 no 780 0.253900281636793 1258 1416193 SGTC_761 k216-0224 480 µM 0.66113716659359 0.226719115644252 no 781 0.254262176041975 1293 1340404 SGTC_399 oxolinic acid 75 µM 0.660106266375599 0.227047123654636 no 782 0.254592818833596 1231 4628 A DNA gyrase inhibitor. SGTC_2562 3',7'-dimethoxyflavone 64.92 µM 0.658631687938159 0.22751676430054 no 783 0.25506615465309 1319 688664 SGTC_3132 9126706 49.47 µM 0.657376387019756 0.227916997660874 no 784 0.255469465409027 1268 850858 SGTC_2747 doxorubicin 7.63 µM 0.657237050987362 0.227961447219131 no 785 0.255514252677799 1154 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_546 peri-Naphthalide 147 µM 0.656914838838463 0.228064254723627 no 786 0.255617838165692 1214 223824 A penicillin ester. SGTC_2035 5154463 94.595 µM 0.655906985622514 0.228385996460461 no 787 0.255941986625065 1251 2769623 SGTC_2698 st077697 67.5 µM 0.655234187654186 0.228600918817869 no 788 0.256158493033667 1206 3154499 SGTC_467 ro 31-8220 72.8 µM 0.653604645963917 0.229121939207732 no 789 0.256683275118355 1223 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7 SGTC_1660 st012960 28.1 µM 0.652835956769025 0.229367946531446 no 790 0.256931020068848 1239 24207266 SGTC_1275 0867-0008 21.1 µM 0.652432664152784 0.229497073413362 no 791 0.257061049144546 1251 3422836 SGTC_3158 9100007 49.47 µM 0.652080004598856 0.229610021896251 no 792 0.257174781218756 1266 19297233 SGTC_2953 9074162 66.49 µM 0.651005512939642 0.229954347975221 no 793 0.257521464077202 1230 16451992 SGTC_3190 9110366 49.47 µM 0.64976224462691 0.230353119771315 no 794 0.257922905152796 1194 17123768 SGTC_2647 atorvastatin 60.16 µM 0.645681747589082 0.231664631125862 no 795 0.259242741798869 1271 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7 SGTC_694 1315-0438 43.2 µM 0.644945863524909 0.231901593506783 no 796 0.259481134444207 1242 6793154 SGTC_673 1082-0474 110 µM 0.644262817916752 0.23212166209695 no 797 0.259702511129951 1287 3098046 SGTC_2553 4-methylesculetin 85.09 µM 0.643360906391787 0.232412424495578 no 798 0.259994972040226 1273 5319502 SGTC_1980 st071811 45.7 µM 0.640932048287377 0.233196457428622 no 799 0.260783416355779 1323 4974850 SGTC_575 k072-0246 11.9 µM 0.639891452988364 0.233532809240549 no 800 0.261121585455793 1298 6796779 SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM 0.639296047283757 0.233725383289258 no 801 0.261315179692462 1296 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding. SGTC_2327 6189656 200 µM 0.639276493828308 0.233731709020963 no 802 0.261321538685383 1330 5349088 SGTC_197 4544-0043 41.561 µM 0.639105428673292 0.233787054297632 no 803 0.261377174293555 1276 896523 SGTC_1596 piperlongumine 63 µM 0.638911313586518 0.233849865791499 no 804 0.261440313810379 1310 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_1438 4092-1045 4 µM 0.638534746306898 0.23397174157844 no 805 0.261562821602561 1271 1351342 SGTC_2634 4'-methoxyflavone 100 µM 0.638264816258538 0.234059125932811 no 806 0.261650655470853 1282 77793 From seeds of Psoralea corylifolia (Fabaceae) SGTC_2448 5185112 27.17 µM 0.637807273448978 0.234207287374646 no 807 0.261799572145283 1274 5718189 SGTC_2252 omeprazole 400 µM 0.637449814673545 0.23432307573982 no 808 0.261915944665353 1241 4594 A proton pump inhibitor. SGTC_3270 9137563 49.47 µM 0.636669183412456 0.234576048622972 no 809 0.262170175321624 1283 17015724 SGTC_1020 4335-0961 93.3 µM 0.635671951859502 0.234899433042116 no 810 0.262495130720689 1239 669075 SGTC_857 0438-0306 1.35 µM 0.634972795955038 0.235126303678243 no 811 0.262723078816232 1306 4686136 SGTC_609 0986-0026 86.3 µM 0.634856212229528 0.23516414595668 no 812 0.262761098839212 1311 2848610 SGTC_1964 st076914 61 µM 0.634433109270181 0.235301510527915 no 813 0.262899103863417 1294 24208661 SGTC_723 4182-0001 115 µM 0.633925563171032 0.235466348824778 no 814 0.263064700890217 1260 744821 YLR208W SEC13 SGTC_491 tetrandrine 80.3 µM 0.633352837179463 0.235652432420657 no 815 0.263251628147605 1325 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_1913 st060213 96.1 µM 0.632673136509839 0.23587337821928 no 816 0.263473557976097 1304 688959 SGTC_340 k038-0059 454 µM 0.632439444495132 0.235949369307765 no 817 0.263549883072911 1285 23733424 SGTC_690 glyoxal 20.3 µM 0.632233618818473 0.236016310099234 no 818 0.26361711621433 1193 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins. SGTC_1472 k841-0093 193 µM 0.629217493706156 0.236998445354708 no 819 0.264603338810622 1345 X1472 SGTC_2238 6671620 73.2395 µM 0.628674035920483 0.237175649040967 no 820 0.264781239790753 1264 729941 SGTC_101 0490-5701 117.494 µM 0.627636505151573 0.237514155692507 no 821 0.265121044417806 1212 4661669 SGTC_3061 glucosamine 200 µM 0.626734356953834 0.237808707584735 no 822 0.265416689435291 1242 91431 and experimental redox chemotherapeutic SGTC_54 0159-0055 9 µM 0.625888851142603 0.238084947475296 no 823 0.265693923840756 1380 3319099 SGTC_2413 inermin 26.06 µM 0.625861126617387 0.23809400848545 no 824 0.265703016970219 1427 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1 SGTC_2336 9001819 198.65 µM 0.625480202427768 0.238218522374094 no 825 0.265827969006116 1389 2989602 SGTC_1464 k208-0027 110 µM 0.625349978630666 0.238261097217522 no 826 0.265870692284596 1377 X1464 SGTC_2133 5320837 200 µM 0.624899275268481 0.238408480530776 no 827 0.26601858401454 1318 2841355 SGTC_553 k007-0256 45.7 µM 0.624865079259994 0.238419664914172 no 828 0.266029806636122 1352 6287000 SGTC_1309 pyrazolanthrone 13.4 µM 0.624481825339555 0.238545034247877 no 829 0.266155601277778 1340 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14 SGTC_2431 5490079 200 µM 0.624031270480504 0.238692465079123 no 830 0.266303524472749 1320 5722345 SGTC_77 0828-0286 12.516 µM 0.623408137946716 0.238896449014773 no 831 0.266508175772329 1270 745345 SGTC_2984 9022109 38.96 µM 0.621138384383971 0.239640263722038 no 832 0.267254287883059 1341 6459207 SGTC_441 propafenone 146 µM 0.620087786552923 0.23998497972172 no 833 0.267599996330235 1262 4932 Slows the influx of sodium ions into the cardiac muscle. SGTC_1944 st076371 56.9 µM 0.619606499592046 0.240142987038936 no 834 0.267758443291004 1287 24208455 SGTC_3241 9133421 49.47 µM 0.619603288509688 0.240144041433057 no 835 0.2677595005867 1318 17018221 SGTC_271 rotenone 740 µM 0.618482698533852 0.240512153498532 no 836 0.268128599590246 1341 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria. SGTC_1801 st050089 28.441 µM 0.616499915355373 0.241164246838763 no 837 0.268782313880376 1324 5008493 YIL048W | YNL267W NEO1 | PIK1 SGTC_2225 6654152 15.4 µM 0.613779472906506 0.242060501596276 no 838 0.269680531758235 1293 97582 YGR029W | YLR033W ERV1 | RSC58 SGTC_290 2043-6722 48.1 µM 0.61367487505747 0.242094997571744 no 839 0.269715097184175 1319 773758 YLR208W SEC13 SGTC_448 monastrol 171 µM 0.612361669209692 0.242528314629962 no 840 0.27014924816672 1300 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity SGTC_2346 9031566 143.75 µM 0.611721046552972 0.242739852510209 no 841 0.27036116729865 1324 4771086 SGTC_1446 4239-0190 62 µM 0.610354222701545 0.243191520543227 no 842 0.270813592701152 1317 1340085 SGTC_2105 5350118 200 µM 0.609433500013966 0.243496030023184 no 843 0.271118569308122 1319 2133313 SGTC_3218 9131285 49.47 µM 0.609333966578277 0.243528960925762 no 844 0.271151548632269 1385 17156417 SGTC_2143 5623677 140.463 µM 0.609321987423352 0.243532924423286 no 845 0.271155517930158 1293 5375313 SGTC_2802 7925815 54.55 µM 0.607717023490599 0.244064267670754 no 846 0.271687585221301 1314 1262923 SGTC_1738 st035555 74 µM 0.607501638426135 0.244135621127913 no 847 0.271759027821992 1334 5331140 SGTC_2896 9052656 71.43 µM 0.607220396586053 0.244228808761448 no 848 0.271852328997031 1302 6469436 SGTC_993 3909-8757 62.7 µM 0.60631110710579 0.244530227031403 no 849 0.272154092198841 1334 4288324 YLR208W SEC13 SGTC_953 1188-0045 9.7 µM 0.604665670360901 0.245076178074748 no 850 0.272700581334339 1368 6144426 SGTC_488 nitrendipine 139 µM 0.604379318880143 0.245171255581301 no 851 0.272795741150292 1366 4507 Dihydropyridine L-type calcium channel blocker. SGTC_49 0717-0965 32.132 µM 0.604356561785507 0.245178812487972 no 852 0.272803304454143 1404 5889349 YGL099W LSG1 SGTC_2716 st080858 38.6235 µM 0.604133421601875 0.245252916874134 no 853 0.272877470442014 1302 5296050 SGTC_179 1273-0063 6.77 µM 0.603588916078407 0.245433796545816 no 854 0.27305849186617 1295 3108139 SGTC_1332 1480-0653 17.5 µM 0.602504010352262 0.245794405741472 no 855 0.273419347254251 1288 5749438 SGTC_2992 9074591 71.4286 µM 0.60185390893805 0.246010627587922 no 856 0.273635693492339 1351 17741321 SGTC_1884 5633444 25 µM 0.600998692583786 0.246295225420757 no 857 0.273920428551967 1352 5724239 SGTC_2906 7926292 26.41 µM 0.60035251574973 0.246510376347545 no 858 0.274135663253595 1318 2966319 SGTC_1506 4226-2149 212 µM 0.599886420389074 0.24666562986841 no 859 0.274290966560381 1384 991114 SGTC_2222 6885208 172.143 µM 0.59931684871283 0.246855421790273 no 860 0.274480807209464 1309 609514 SGTC_2184 6075246 200 µM 0.59891855473749 0.246988187210427 no 861 0.274613598787474 1364 2267320 SGTC_2847 9005661 71.43 µM 0.59860476151084 0.247092812454597 no 862 0.274718240050484 1260 2991449 SGTC_648 0375-0473 33.3 µM 0.598378314707852 0.247168329293568 no 863 0.27479376593636 1356 1713139 SGTC_2468 5987765 72.9 µM 0.597534052158937 0.247449987797705 no 864 0.275075439597884 1402 26772094 SGTC_1051 3253-3903 78 µM 0.597111953840109 0.247590870342037 no 865 0.275216318736093 1305 5509239 SGTC_469 w7 172 µM 0.596629285342338 0.247752021717192 no 866 0.275377457240387 1370 45115570 A P450 inhibitor. SGTC_464 bw-b 70c 158 µM 0.595768424189576 0.248039581468616 no 867 0.275664970258137 1377 5353454 SGTC_2427 5545055 42.75 µM 0.595093579918517 0.248265129090417 no 868 0.275890459933002 1394 5372858 SGTC_638 3970-0837 4.09 µM 0.594919971863682 0.248323170355175 no 869 0.275948483260868 1328 4118451 YLR208W SEC13 SGTC_2313 7726885 200 µM 0.594501516966479 0.248463099416975 no 870 0.276088363991985 1338 726423 SGTC_2042 p-Dimethylaminoacetophenone 200 µM 0.593591613036336 0.248767511348651 no 871 0.276392645962604 1320 75037 A free radical scavenger. SGTC_2860 9025725 38.96 µM 0.591467825937755 0.249478804642027 no 872 0.277103503294909 1300 40546248 SGTC_2220 6782180 200 µM 0.590288582469811 0.249874219971313 no 873 0.277498596336687 1312 833803 SGTC_2104 5389443 200 µM 0.590161089971232 0.249916989745922 no 874 0.277541327835094 1432 2244536 SGTC_2914 7968218 45.32 µM 0.589008674462248 0.250303765593935 no 875 0.277927727302942 1375 2977111 SGTC_1713 st033146 12.748 µM 0.588953539116634 0.250322278173355 no 876 0.277946220502746 1417 674619 SGTC_973 1325-0077 65.9 µM 0.588775711430683 0.250381991625957 no 877 0.278005870596331 1427 2835149 SGTC_1930 st074634 34.3 µM 0.588063699056347 0.250621156658647 no 878 0.278244768879802 1325 684253 YOR116C RPO31 SGTC_123 0083-0120 66.675 µM 0.586873289791863 0.251021285389796 no 879 0.278644404930182 1304 16001701 SGTC_943 3253-1379 105 µM 0.585544825114351 0.25146821705002 no 880 0.279090717736486 1408 668464 SGTC_2119 5528445 120.635 µM 0.585389205396345 0.251520599258571 no 881 0.27914302268473 1428 791935 SGTC_884 0851-0618 334 µM 0.585305698807163 0.251548710281368 no 882 0.279171091836958 1351 9642473 SGTC_2666 tannic acid 100 µM 0.584489321550248 0.251823616723595 no 883 0.279445573778649 1394 16134267 A thiamine antagonist. SGTC_961 1252-1571 372 µM 0.58281078024925 0.252389345754732 no 884 0.280010343525533 1436 6813498 SGTC_2850 9015429 58.44 µM 0.582539387358325 0.252480877829485 no 885 0.280101709568758 1360 6457570 SGTC_2518 prenyletin 46.28 µM 0.58235598266288 0.252542744225304 no 886 0.280163462038756 1307 3873459 A coumarin with calcium channel inhibitory activity. SGTC_2582 agaric acid 100 µM 0.58021142457334 0.253266742644092 no 887 0.280886025144053 1264 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase. SGTC_2294 7971431 200 µM 0.579595149337439 0.253474997581535 no 888 0.281093832446645 1367 5741572 SGTC_2549 cedrol 20.94 µM 0.579345873518588 0.253559259717066 no 889 0.281177909057561 1407 6708665 A sedative which affects the nervous system. SGTC_3055 9094636 49.47 µM 0.578858547248105 0.253724031998041 no 890 0.28134231121964 1410 25236176 SGTC_809 3998-0021 90 µM 0.57880465414458 0.25374225751237 no 891 0.281360495199446 1325 715485 SGTC_2587 piperic acid 92.2 µM 0.578529500919834 0.253835319259944 no 892 0.281453343018145 1341 5370536 SGTC_2924 9010168 62.78 µM 0.575693990836918 0.254795382226982 no 893 0.282411018890756 1386 2993929 SGTC_875 0709-0210 25.7 µM 0.575209725831736 0.254959537240519 no 894 0.28257473294394 1397 6251364 SGTC_2940 9060638 45.86 µM 0.57445340055834 0.255216025267814 no 895 0.282830512848603 1412 4027022 SGTC_3076 9116187 49.47 µM 0.572189745029377 0.255984490526711 no 896 0.283596717104485 1406 27241210 SGTC_223 busulfan 5 mM 0.571544644014541 0.256203710099855 no 897 0.283815253446938 1396 2478 A DNA alkylator. SGTC_1005 4092-0690 4.4 µM 0.569981385222196 0.256735345685527 no 898 0.284345161803552 1356 1529343 SGTC_960 1222-0186 7.7 µM 0.569836744441272 0.256784564368061 no 899 0.284394215551352 1434 3126296 SGTC_1198 1612-1005 86.7 µM 0.569298111363617 0.256967894806004 no 900 0.284576924149492 1451 6998509 SGTC_1588 farnesol 29.9 µM 0.568379923372028 0.257280568362838 no 901 0.284888509931109 1380 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_1911 st060208 74.3 µM 0.564266660439855 0.258683694616661 no 902 0.286286333686508 1459 688783 SGTC_702 1488-0190 94 µM 0.563492625372539 0.2589481775048 no 903 0.286549740196201 1421 949357 SGTC_253 dyclonine 31.25 µM 0.562633577032199 0.259241872569665 no 904 0.286842211517014 1438 3180 An oral anasthetic. SGTC_1600 coumarin 106 71.1 µM 0.562597102187831 0.259254346552053 no 905 0.286854632861026 1435 100336 A hepatotoxic, DNA x-linker. SGTC_237 nikkomycin 200 µM 0.560992982113542 0.259803244033917 no 906 0.287401160676406 1459 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine. SGTC_1077 5-fluorocytosine 377 nM 0.56034310185259 0.260025790483669 no 907 0.287622716650014 1398 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_3236 9132701 49.47 µM 0.558825559948572 0.260545843428544 no 908 0.288140388333471 1353 24282524 SGTC_3262 9137218 49.47 µM 0.558681214551376 0.260595337647945 no 909 0.288189651063478 1302 17650664 SGTC_1494 4358-1428 177 µM 0.558590936255187 0.260626295399119 no 910 0.288220463593108 1492 1564571 SGTC_3341 9147222 25.867 µM 0.55798168868918 0.260835264804108 no 911 0.288428444098293 1395 1939759 SGTC_2563 tomatine 8.54 µM 0.557364134520489 0.261047171267601 no 912 0.288639332418431 1459 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties. SGTC_3233 9132340 49.47 µM 0.556282047452982 0.261418690032932 no 913 0.289009028911872 1357 17682950 SGTC_3109 9122853 49.47 µM 0.556005305365562 0.261513748962977 no 914 0.289103613973274 1481 1234709 SGTC_1403 3909-7815 62.9 µM 0.555103436153618 0.261823657697226 no 915 0.289411956302916 1424 6615483 SGTC_1398 3558-0053 112 µM 0.554124800389685 0.262160158653937 no 916 0.289746719214039 1372 4532369 SGTC_1950 st077106 7.18 µM 0.553099727457253 0.26251286436843 no 917 0.290097561645578 1378 13831864 SGTC_1715 st032160 10.2275 µM 0.551432544148101 0.263087024887964 no 918 0.290668598233276 1403 5289825 SGTC_2754 granisetron 64.02 µM 0.5513235901881 0.263124569820572 no 919 0.29070593497922 1476 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients. SGTC_1855 st056195 39.6 µM 0.550887522186717 0.263274863844665 no 920 0.290855390823305 1457 4028379 SGTC_2389 9091542 195.52 µM 0.550575612329914 0.263382392746047 no 921 0.290962315332075 1391 3626624 YOL127W RPL25 SGTC_3326 9140064 16.379 µM 0.550089243598871 0.263550109944029 no 922 0.291129081995663 1377 1868434 SGTC_1070 indatraline 8.81 µM 0.550041934320759 0.263566426769912 no 923 0.291145305836573 1381 10314472 A monamine transport inhibitor. YGL099W LSG1 SGTC_2900 5328528 85.29 µM 0.549290149052811 0.263825784380245 no 924 0.291403173315889 1370 795359 SGTC_612 0302-0167 22.4 µM 0.54898952139643 0.263929534010604 no 925 0.291506320471294 1493 235821 SGTC_722 3534-0461 190 µM 0.54830949823182 0.264164293550877 no 926 0.291739703306372 1380 658262 SGTC_183 3914-0051 30.55 µM 0.547513217642654 0.264439322939548 no 927 0.292013096121138 1498 1596232 SGTC_458 nppb 133 µM 0.545764088277855 0.26504397042702 no 928 0.292614055838487 1523 4549 A chloride channel blocker. SGTC_701 4424-0219 185 µM 0.544902217072218 0.265342164323621 no 929 0.292910385681207 1475 2911779 SGTC_2941 9056145 11.23 µM 0.54385779856875 0.265703744780125 no 930 0.293269665739801 1340 2119517 SGTC_1470 k295-0292 231 µM 0.543818503884575 0.265717353578759 no 931 0.293283187101006 1474 5045612 SGTC_2782 7736369 71.43 µM 0.541969877781411 0.266357981288819 no 932 0.293919628477211 1444 2950836 YOL077C BRX1 SGTC_2690 usnic acid 100 µM 0.541389196812932 0.266559373168448 no 933 0.294119675928476 1558 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_1579 chlormadinone acetate 49.4 µM 0.540842318954778 0.266749111832571 no 934 0.294308135556631 1504 45114258 A steroidal progestin. SGTC_532 1548-0774 215 µM 0.540453300031431 0.266884123050923 no 935 0.294442229339049 1529 5932993 SGTC_2418 pentamidine 31.67 µM 0.537817660977492 0.26779974483848 no 936 0.29535146897478 1378 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_1960 st011366 51.8 µM 0.537758218927161 0.267820413258543 no 937 0.295371990111745 1422 3972846 SGTC_2204 7233102 200 µM 0.536195877530845 0.268363938346015 no 938 0.295911591172072 1426 2172480 SGTC_2412 st077135 33.4 µM 0.535611457961213 0.268567395347518 no 939 0.296113554119525 1508 13258915 SGTC_1565 sinapyl alcohol 95.1 µM 0.535138651888093 0.268732052479907 no 940 0.296276992092218 1370 5280507 A phenol propionate derived from cinnamic acid. SGTC_2378 9074213 121.43 µM 0.533625528699412 0.269259345994161 no 941 0.296800321139664 1398 657714 SGTC_2461 5755302 26.15 µM 0.533192203039533 0.269410446946035 no 942 0.296950269129382 1530 2788904 SGTC_1979 st071809 45.3 µM 0.531621445410902 0.269958527279585 no 943 0.297494104312011 1484 4976333 SGTC_3010 9080089 71.4286 µM 0.528425966430742 0.271075236966098 no 944 0.298601859471343 1503 17027233 SGTC_1876 myriocin 605 nM 0.52713442029666 0.271527240675671 no 945 0.299050122771623 1530 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1 SGTC_2144 5628481 200 µM 0.526562041222548 0.271727676732889 no 946 0.299248878866014 1446 2818399 SGTC_514 4466-0038 2.65 nM 0.526184503644774 0.271859923370578 no 947 0.29938000991001 1472 5722064 SGTC_1929 genistein trimethyl ether 50.5 µM 0.525217525975621 0.27219878939552 no 948 0.299715991397735 1574 136420 SGTC_668 1682-0499 62.6 µM 0.525216835838554 0.272199031320938 no 949 0.299716231250474 1459 682214 SGTC_18 0111-0177 500 nM 0.524015045364457 0.272620477314516 no 950 0.300134037691745 1489 721752 SGTC_455 paf C-16 10 µM 0.523711483163425 0.272726982254898 no 951 0.300239613751576 1438 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis. SGTC_764 1951-2361 146 µM 0.523657368114188 0.27274597071331 no 952 0.300258436216505 1391 5438930 SGTC_2135 5326629 150.42 µM 0.523012565125503 0.272972276437489 no 953 0.300482754631233 1417 5020077 SGTC_3287 9117173 37.0625 µM 0.521777451174196 0.273406022681727 no 954 0.300912645619711 1432 2789709 SGTC_2205 7238770 200 µM 0.52057087489603 0.27383007634753 no 955 0.301332871456856 1484 279867 SGTC_1214 0358-0031 63.7 µM 0.520461719168105 0.273868455384004 no 956 0.301370901194295 1642 4301366 SGTC_1796 st049173 110.4 µM 0.520449449850167 0.273872769429248 no 957 0.301375175946464 1422 94134 SGTC_1567 st069303 68.4 µM 0.520225088794543 0.273951663499381 no 958 0.301453350378499 1462 5581319 SGTC_2203 7227154 166.4 µM 0.519573915896441 0.274180704803483 no 959 0.301680291113264 1448 896304 SGTC_3339 9145883 14.936 µM 0.519501596557637 0.274206147992092 no 960 0.301705499917298 1462 2030670 SGTC_1365 1672-3266 55.4 µM 0.517165147296816 0.275028777914784 no 961 0.302520439683685 1490 6415873 SGTC_1133 3473-0247 50 µM 0.516315831180362 0.275328110803609 no 962 0.302816920505643 1401 711311 SGTC_1977 st070720 65.3 µM 0.514795104881674 0.275864475658299 no 963 0.303348103191663 1450 682188 SGTC_2942 9052777 62.25 µM 0.51361588038853 0.276280744846111 no 964 0.303760287282531 1517 6469503 SGTC_2393 9031399 185.94 µM 0.513543141585169 0.276306431913258 no 965 0.303785720459411 1524 1526623 YDL150W RPC53 SGTC_2310 7668677 200 µM 0.509621985608428 0.277692884982923 no 966 0.305158159030547 1516 2197143 SGTC_1372 2752-0194 270 µM 0.509185864999694 0.277847299434809 no 967 0.305310974958526 1409 823334 SGTC_2345 9052315 157.45 µM 0.508159194593212 0.278210971504984 no 968 0.305670852493492 1482 6469265 SGTC_161 4065-0411 162.148 µM 0.508060235752371 0.27824603743669 no 969 0.305705550343991 1523 1906281 YLR208W SEC13 SGTC_3035 9091303 49.47 µM 0.505136225774987 0.279283127815697 no 970 0.30673157961172 1481 25237002 SGTC_2295 7971645 200 µM 0.504681561623952 0.27944455707531 no 971 0.306891256764515 1537 2978226 YKL099C UTP11 SGTC_671 0560-0003 407 µM 0.504598279074963 0.279474131592262 no 972 0.306920509402972 1511 3238678 SGTC_330 1488-0319 80.1 µM 0.502952458828954 0.280058891442572 no 973 0.30749884871422 1487 6846614 SGTC_1989 st071868 50.2 µM 0.501249005422029 0.280664752234329 no 974 0.308097944616407 1576 16414057 SGTC_3297 9117502 71.43 µM 0.500382102561248 0.280973323526493 no 975 0.308403026515951 1470 7453720 SGTC_2421 5690543 90.72 µM 0.496778948878248 0.282257608422665 no 976 0.309672470853248 1522 3397993 SGTC_76 0433-0009 400.328 µM 0.494463914260406 0.283084252305969 no 977 0.310489292621172 1493 2841569 SGTC_2434 5670830 169.91 µM 0.494202478371408 0.283177677816904 no 978 0.310581594813853 1488 1549830 SGTC_2127 5253358 187.912 µM 0.493147363643103 0.283554878945807 no 979 0.310954233304279 1433 20612 SGTC_1251 0490-5699 265 µM 0.491601060410845 0.284108113422903 no 980 0.311500696827259 1588 3883818 SGTC_139 0099-0334 718.624 µM 0.491019583131332 0.284316287139448 no 981 0.311706298452611 1508 97690 SGTC_3009 9080819 71.4286 µM 0.490964305322355 0.28433608085028 no 982 0.311725846911727 1489 17027216 SGTC_1653 st012112 65 µM 0.490897514195502 0.284359998093776 no 983 0.311749467651446 1528 720429 SGTC_2103 5378138 10 µM 0.490874893600568 0.284368098523561 no 984 0.311757467619959 1550 244142 SGTC_3340 9146634 11.102 µM 0.490048880807679 0.284663969017324 no 985 0.312049654990076 1498 4907387 SGTC_2797 7859098 81.82 µM 0.488437453215584 0.285241590796603 no 986 0.312620009271734 1486 972681 SGTC_1012 4112-3522 18 µM 0.487256543616738 0.285665246195272 no 987 0.313038269729248 1578 3112398 SGTC_189 3970-0742 2.116 µM 0.486570621539265 0.285911460484501 no 988 0.313281323589274 1528 2891807 SGTC_2955 9076254 12.21 µM 0.484925434350729 0.286502417390208 no 989 0.313864619869401 1541 16459619 SGTC_1178 0988-0033 191 µM 0.484610164897484 0.286615729398744 no 990 0.313976450917601 1527 5392207 SGTC_1076 itraconazole 331 nM 0.484360777739955 0.286705377493029 no 991 0.314064924580849 1498 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1 SGTC_740 k014-0057 261 µM 0.482173704642606 0.287492141465244 no 992 0.314841277449542 1616 4012779 SGTC_2340 7987427 183.45 µM 0.480583200858094 0.288064939757333 no 993 0.315406378671531 1541 2239331 SGTC_2221 6807166 181.081 µM 0.479027552583044 0.288625705803086 no 994 0.315959513853838 1556 674925 SGTC_2987 9018338 71.43 µM 0.478102534760813 0.288959391474452 no 995 0.316288614030713 1526 5055682 SGTC_2808 7946468 45.46 µM 0.477781737297633 0.289075156502905 no 996 0.316402780437071 1555 2970879 SGTC_1568 digitonin 820 nM 0.476494862972997 0.289539765336815 no 997 0.316860933115578 1674 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1 SGTC_3148 9097893 49.47 µM 0.473611371147177 0.290582082756127 no 998 0.317888532580742 1392 17174100 SGTC_359 0081-0058 15.9 µM 0.473551142531759 0.290603872751345 no 999 0.31791001144603 1671 3494159 SGTC_2711 st079103 59.1 µM 0.47291831102568 0.290832869848454 no 1000 0.318135730274775 1621 54693780 SGTC_1739 st037196 92.5 µM 0.472885695589552 0.290844674391171 no 1001 0.318147365405027 1632 612214 SGTC_3237 9133362 49.47 µM 0.472607549273783 0.290945353309072 no 1002 0.3182465977551 1573 43845137 SGTC_2692 st077426 47.7 µM 0.471214065335616 0.29144998916066 no 1003 0.318743937716632 1592 25238571 SGTC_3273 9137859 49.47 µM 0.470989138208885 0.29153148245829 no 1004 0.318824245743271 1570 2377234 SGTC_2520 obtusaquinone 4.71 µM 0.470409583845729 0.291741509621622 no 1005 0.319031209146263 1613 5967872 SGTC_632 0781-2353 4.65 µM 0.46988928943425 0.291930121363288 no 1006 0.319217058429284 1550 6811515 YHR007C ERG11 SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM 0.469468177042182 0.292082820234778 no 1007 0.31936751314812 1652 6728940 SGTC_481 bay k-8644 50 µM 0.468464752927175 0.29244681995123 no 1008 0.319726135613433 1482 2303 A calcium channel antagonist. SGTC_2595 hexamethylquercetagetin 100 µM 0.46809233993849 0.292581969225299 no 1009 0.319859278446775 1545 386331 SGTC_1771 st048882 4.1505 µM 0.467192296017659 0.292908716376127 no 1010 0.32018115250152 1459 4580403 SGTC_1236 0330-0013 258 µM 0.465839863255892 0.293400014537307 no 1011 0.320665064503618 1528 4617066 SGTC_3193 9111931 49.47 µM 0.465746903661048 0.293433797981939 no 1012 0.320698337450578 1567 17087244 SGTC_342 k048-0088 23.3 µM 0.465677529332521 0.293459011225844 no 1013 0.320723169482399 1491 6820570 SGTC_2844 9010103 25.97 µM 0.465028087163705 0.293695091625283 no 1014 0.320955671435996 1520 2480525 SGTC_2513 baicalein 25.65 µM 0.464560451711815 0.293865137411002 no 1015 0.32112312961569 1451 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2 SGTC_3246 9135460 32.98 µM 0.464553748666197 0.293867575163435 no 1016 0.321125530211139 1554 41446951 SGTC_3300 9124615 50.48 µM 0.463580649219095 0.294221569545324 no 1017 0.321474110482272 1607 24824903 SGTC_2921 7974240 10.71 µM 0.463390270832682 0.294290848480139 no 1018 0.321542325563921 1587 2979074 YDR527W RBA50 SGTC_1881 5652484 16 µM 0.462255015492966 0.29470412565961 no 1019 0.321949227372028 1621 2255129 SGTC_125 0133-0007 11.75 µM 0.460412841746616 0.295375317619166 no 1020 0.322609959427862 1700 26541 SGTC_2581 avocatin a 64 µM 0.459784865216082 0.295604280120917 no 1021 0.322835323855507 1531 6710728 A skin care supplement. SGTC_3302 9125395 16.351 µM 0.459368345856915 0.295756189568158 no 1022 0.322984837711989 1572 17599668 SGTC_2003 4023581 200 µM 0.45804208788011 0.296240130018734 no 1023 0.323461101975396 1537 16641307 SGTC_115 0527-0192 112.043 µM 0.457804023898481 0.296327036010029 no 1024 0.32354662230923 1546 4233931 SGTC_2576 guaiol 23.12 µM 0.456814812852581 0.296688275699116 no 1025 0.323902078917885 1693 227829 SGTC_2074 5212007 75.395 µM 0.456804083771476 0.29669219484586 no 1026 0.32390593511674 1621 758611 SGTC_2730 imipramine 71.33 µM 0.456025695795518 0.296976589663317 no 1027 0.324185750280184 1570 3696 A tricyclic antidepressant. SGTC_128 0906-2981 13.371 µM 0.453184288462036 0.298015794045355 no 1028 0.325208022503745 1617 6740226 SGTC_1508 1080-0625 72.9 µM 0.452290587419573 0.298342994788692 no 1029 0.325529827950825 1535 767111 SGTC_2805 7950783 58.44 µM 0.451523445017557 0.298623990399114 no 1030 0.325806165719436 1594 1178958 YDL195W SEC31 SGTC_886 0866-0150 153 µM 0.451005676386509 0.29881371120904 no 1031 0.325992728925895 1682 271463 SGTC_3072 9116419 49.47 µM 0.450081247991134 0.299152576435558 no 1032 0.326325928731979 1494 17170162 SGTC_2344 7990960 76.95 µM 0.450046540788836 0.299165302357664 no 1033 0.326338441254402 1562 140813 SGTC_1614 st002383 48.6 µM 0.448973214873344 0.299558974806053 no 1034 0.326725489481145 1550 1947235 SGTC_2161 5662504 8.5105 µM 0.447580446975214 0.300070161254282 no 1035 0.327228008598344 1539 2859334 SGTC_1658 st012944 20 µM 0.447431328591596 0.300124915429115 no 1036 0.327281830001577 1594 24207260 SGTC_1315 1237-0019 3.69 µM 0.445342391737328 0.300892418201558 no 1037 0.328036168527113 1630 825140 SGTC_2049 5262831 67.185 µM 0.445004681297147 0.301016580515295 no 1038 0.328158185549974 1569 763417 SGTC_954 1189-0853 2.85 µM 0.443098612101033 0.301717796801214 no 1039 0.328847204518198 1549 2828194 SGTC_2700 st077718 96.8 µM 0.442044758605341 0.302105809831156 no 1040 0.329228408761173 1552 904970 SGTC_2223 6903751 107.57 µM 0.441735623003281 0.302219671400207 no 1041 0.329340264278595 1600 5598863 SGTC_3111 9122088 49.47 µM 0.439387808563771 0.303085051864454 no 1042 0.330190279381667 1631 16876704 SGTC_1064 honokiol 6.76 µM 0.437283201527603 0.303861729380139 no 1043 0.330952988220321 1568 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis. SGTC_1010 4112-3296 15.2 µM 0.436514455802403 0.304145646061246 no 1044 0.331231756643306 1721 704384 SGTC_1246 0422-0085 105 µM 0.436045390334493 0.304318941505135 no 1045 0.331401898701216 1661 264295 SGTC_1613 st002381 52.1 µM 0.436032121846131 0.304323844165105 no 1046 0.331406712028059 1558 551167 SGTC_270 tamoxifen 5.46 µM 0.435743156769992 0.304430624470366 no 1047 0.331511544994104 1699 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  YIL048W NEO1 SGTC_3197 9113331 49.47 µM 0.434126057046856 0.305028493482093 no 1048 0.332098452274124 1683 16610459 YLR208W | YDL195W SEC13 | SEC31 SGTC_2796 7949634 45.45 µM 0.43284856133022 0.305501173504546 no 1049 0.332562395764629 1551 2971588 SGTC_3281 9140613 49.47 µM 0.432150235518862 0.305759694849932 no 1050 0.332816112735483 1477 16013766 SGTC_2055 5235184 200 µM 0.429529375605608 0.306730804299703 no 1051 0.333769010403174 1592 2836034 SGTC_3004 9076122 71.4286 µM 0.429078753909464 0.306897910559482 no 1052 0.333932956655793 1652 44782551 SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM 0.42904267549431 0.306911291431144 no 1053 0.333946084161308 1666 1377 SGTC_1714 st033236 13.627 µM 0.428206633256207 0.307221437319629 no 1054 0.334250343684434 1686 2916566 SGTC_1461 k072-0203 53.8 µM 0.427882871049737 0.307341580179223 no 1055 0.334368199222878 1527 5418714 SGTC_2915 7971052 15.16 µM 0.426778136143266 0.307751684823881 no 1056 0.334770466375679 1518 5741558 SGTC_2771 fluoxetine 41.05 µM 0.425085240758454 0.308380595216925 no 1057 0.335387268369563 1639 3386 A selective serotonin reuptake inhibitor. SGTC_942 3253-1115 227 µM 0.42492259063376 0.308441049375757 no 1058 0.335446552918901 1676 46497897 SGTC_1751 st044839 27.194 µM 0.42054837910206 0.310068809951337 no 1059 0.337042447506836 1619 5291326 SGTC_1698 5-fluorocytosine 1.055 µM 0.420089040171941 0.31023995910406 no 1060 0.337210204405241 1698 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_3092 9117248 49.47 µM 0.419291236142599 0.310537317649565 no 1061 0.337501650343753 1690 17141857 SGTC_540 1187-0821 17.3 µM 0.419157387515366 0.310587218019272 no 1062 0.337550556166709 1561 847520 SGTC_1578 josamycin 24.2 µM 0.418436601290954 0.310855995649966 no 1063 0.337813965331335 1536 5282165 A P450 substrate. SGTC_1004 4084-0029 199 µM 0.418421184465442 0.310861745611393 no 1064 0.337819600232322 1717 716894 YLR208W SEC13 SGTC_1815 st051655 58.2 µM 0.417859018780276 0.311071446188792 no 1065 0.338025098479334 1682 5984156 SGTC_2820 7989630 71.43 µM 0.417478122296728 0.31121356410556 no 1066 0.338164361667919 1682 2984098 SGTC_2578 7,8-dihydroxyflavone 64.44 µM 0.416452672129925 0.311596314056393 no 1067 0.338539396287895 1490 1880 Intensifies effect of antibiotics on Staphylococcus aureus. SGTC_3019 9081971 49.47 µM 0.415413455529518 0.311984410134712 no 1068 0.338919629093795 1709 16451803 SGTC_2495 cafestol 54.53 µM 0.414875907874555 0.312185239606394 no 1069 0.339116373669989 1635 16667697 An anti-infammatory. SGTC_105 0111-0055 734.78 µM 0.413774224008332 0.312597006510481 no 1070 0.339519731414057 1607 5179370 SGTC_791 1348-1292 225 µM 0.413246968246116 0.3127941572031 no 1071 0.339712839815888 1698 5437054 SGTC_812 4251-0442 148 µM 0.412613224483825 0.313031196610896 no 1072 0.339945005328327 1627 5723007 SGTC_730 1436-0052 41.2 µM 0.41180575042304 0.313333328411552 no 1073 0.340240903104877 1620 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2 SGTC_2047 4141938 200 µM 0.410223335892291 0.313925782263502 no 1074 0.340821062013441 1624 3807862 SGTC_2898 9056270 58.44 µM 0.40989601637192 0.314048390209363 no 1075 0.34094111387324 1609 19154699 SGTC_2400 5203494 178.7 µM 0.40894020049895 0.314406538929658 no 1076 0.341291773186409 1566 6777674 SGTC_103 0844-0104 51.839 µM 0.408036825344252 0.314745198522958 no 1077 0.34162331963848 1700 5375804 SGTC_1356 1502-0781 85.8 µM 0.40778334600285 0.314840251524902 no 1078 0.34171637070751 1616 567702 SGTC_765 1319-0117 244 µM 0.407699351158043 0.314871751717832 no 1079 0.341747206940319 1548 3487746 YGL099W LSG1 SGTC_580 1123-0028 41 µM 0.406573716487082 0.315294023106123 no 1080 0.342160552376959 1642 1677248 YPR107C YTH1 SGTC_2224 6650123 117.647 µM 0.404631158986241 0.316023323082112 no 1081 0.342874325637722 1624 2908370 SGTC_1819 st053448 58.6 µM 0.404189753259915 0.316189141320256 no 1082 0.343036594080551 1649 2857616 SGTC_461 N-acetylfarnesylcysteine 136 µM 0.40269114592546 0.316752383052798 no 1083 0.343587724128169 1631 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ). SGTC_578 3460-0051 92 µM 0.402626978889281 0.316776509311029 no 1084 0.343611329727178 1719 2876744 SGTC_135 0933-0004 26.348 µM 0.402511500964059 0.316819929989005 no 1085 0.343653812976215 1569 21230617 YGL099W LSG1 SGTC_1346 1488-2224 62.4 µM 0.402509120164155 0.316820825216485 no 1086 0.343654688871018 1709 3722427 SGTC_2922 7999257 32.47 µM 0.402452699585991 0.316842040774859 no 1087 0.343675446212248 1583 2988377 SGTC_1810 st050138 53 µM 0.402197967037185 0.316937834126627 no 1088 0.343769169134532 1725 3444541 SGTC_1603 st002045 67.8 µM 0.401787318942429 0.317092286076498 no 1089 0.343920277774633 1709 5887985 SGTC_227 fluconazole 33.516 µM 0.399755223511192 0.317857061455379 no 1090 0.344668406673816 1587 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C SGTC_2843 9000894 45.46 µM 0.398896585864487 0.318180442050272 no 1091 0.344984702474339 1579 2242070 SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM 0.398853750349687 0.318196578418695 no 1092 0.345000484604704 1786 551469 SGTC_2717 st081029 62.2815 µM 0.398798434164114 0.318217416833291 no 1093 0.345020865457937 1702 5292846 SGTC_263 alizarin 107.927 µM 0.398771605472979 0.318227523800074 no 1094 0.345030750459358 1661 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. SGTC_338 4055-0136 114 µM 0.398363533959419 0.318381270127822 no 1095 0.345181116989007 1590 2900563 SGTC_1712 st032288 53.4 µM 0.39791002279168 0.318552173150873 no 1096 0.345348255839552 1601 2883011 SGTC_2195 6536160 144.242 µM 0.397848788481293 0.318575251900934 no 1097 0.345370825693407 1573 3834386 SGTC_2657 nystatin 74.44 µM 0.397027299561536 0.318884932914543 no 1098 0.345673664718274 1662 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_2175 5807670 165.306 µM 0.393695605054036 0.320142194356248 no 1099 0.346902893263088 1682 241186 SGTC_1428 4049-0204 61.7 µM 0.392465536593881 0.320606901356567 no 1100 0.347357135379247 1725 X1428 SGTC_2749 bexarotene 57.39 µM 0.391882365680641 0.320827315580868 no 1101 0.347572566569516 1572 82146 An retinoic acid receptor inhibitor. SGTC_1631 benzylvanillin 81.9 µM 0.391644395144496 0.320917276647507 no 1102 0.347660490240243 1669 75506 SGTC_1454 4239-0054 42.6 µM 0.38993749991726 0.321562849817185 no 1103 0.348291381756482 1733 1340767 SGTC_591 4299-0174 154 µM 0.388484237637379 0.322112920369069 no 1104 0.348828858235152 1666 5509088 SGTC_133 0724-0033 378.92 µM 0.384875123502207 0.323480681333611 no 1105 0.350164968717198 1615 280309 SGTC_2891 9063876 19.48 µM 0.384452162812367 0.323641129215519 no 1106 0.350321672555581 1747 6472478 SGTC_2694 st077685 81.9 µM 0.384010949767531 0.323808535973101 no 1107 0.350485165914147 1594 2838096 SGTC_424 splitomicin 100 mM 0.383745294323191 0.32390934918509 no 1108 0.350583619025217 1580 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_2726 cimetidine 79.27 µM 0.379596630768325 0.325485391886075 no 1109 0.352122431101469 1680 2756 A P450 inhibitor, histamine H2-receptor antagonist. SGTC_3138 9097216 49.47 µM 0.379345916707708 0.325580736491953 no 1110 0.352215503282271 1664 25237486 SGTC_1725 st036284 20.55 µM 0.378290666098655 0.325982165137803 no 1111 0.35260733926465 1808 707914 SGTC_148 3253-0744 288.01 µM 0.377890709113916 0.326134365820516 no 1112 0.35275589232159 1613 6893655 SGTC_67 0335-0847 266 µM 0.377287150260752 0.32636410052557 no 1113 0.352980110213186 1875 4552207 YOR254C SEC63 SGTC_1583 clindamycin 39.6 µM 0.375996290858216 0.326855665895324 no 1114 0.353459826755892 1581 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis. SGTC_1752 st044819 83.042 µM 0.37504307426824 0.327218848313757 no 1115 0.353814216070584 1606 441209 YML126C ERG13 SGTC_1681 tripelennamine 100 µM 0.37491890826195 0.3272661685144 no 1116 0.353860388161601 1609 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist. SGTC_3173 9105693 49.47 µM 0.374694289624964 0.327351778699334 no 1117 0.353943919802175 1727 17096658 SGTC_2236 dapsone 200 µM 0.37445403895852 0.327443356860454 no 1118 0.354033272495461 1707 2955 A bacterial DFR inhibitor. An anti-cancer agent. SGTC_880 0833-0487 87.2 µM 0.373960514667162 0.327631509813998 no 1119 0.354216846521046 1633 76075 SGTC_2908 7930301 100 µM 0.371087192259031 0.328727813591733 no 1120 0.355286295083633 1585 2223178 SGTC_3234 9132280 49.47 µM 0.370011436838848 0.329138643594254 no 1121 0.355686984433377 1672 17612295 SGTC_1473 k844-0725 134 µM 0.369592991100518 0.32929850343068 no 1122 0.355842887094568 1725 54682906 SGTC_1757 st041620 31.8375 µM 0.369472551666337 0.329344520984511 no 1123 0.355887764355902 1645 5289815 SGTC_420 mitomycin C 81.9 mM 0.36904877391593 0.329506458726898 no 1124 0.356045685194513 1654 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_2267 7931562 200 µM 0.367439112794407 0.330121848026571 no 1125 0.356645750519859 1563 934880 SGTC_570 0987-0065 62.6 µM 0.365190906838061 0.330982128813232 no 1126 0.35748445277736 1753 3104428 SGTC_622 1348-1566 26.3 µM 0.364786223227809 0.331137076843814 no 1127 0.357635494889629 1768 7340407 SGTC_176 1486-1328 72.834 µM 0.362400393125233 0.332051166924583 no 1128 0.358526422882622 1635 22310231 SGTC_1973 st070275 50.2 µM 0.361355774257862 0.332451710038995 no 1129 0.358916752256543 1721 17118334 SGTC_941 3237-0776 460 µM 0.36023981857063 0.332879817625477 no 1130 0.359333899946679 1788 760008 SGTC_2673 kobusone 100 µM 0.359735154965099 0.333073490390708 no 1131 0.359522599869222 1748 6710676 An epoxy ketone and protein crosslinker. SGTC_1019 4262-0212 3.4 µM 0.358910601157156 0.333390021958072 no 1132 0.359830984368273 1816 4677213 SGTC_3064 1327-0027 10 µM 0.358435248872061 0.333572555205533 no 1133 0.360008808405599 1667 16000455 YPR107C YTH1 SGTC_2776 terbinafine 19.92 µM 0.357971007853057 0.333750859810301 no 1134 0.360182505087963 1685 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_518 1021-0119 62.6 µM 0.355488587987719 0.334704938216466 no 1135 0.361111796417032 1627 1097762 SGTC_1665 st014639 11.4 µM 0.355197849312005 0.334816748973098 no 1136 0.361220687909483 1754 981133 YIL048W NEO1 SGTC_2197 6588183 93.1375 µM 0.35476467762032 0.334983363036019 no 1137 0.361382946252865 1718 884136 SGTC_1009 4106-0057 9.87 µM 0.353781004716928 0.335361841080756 no 1138 0.361751505041946 1808 2928005 SGTC_386 1509-0011 3.07 µM 0.352367701124555 0.335905916406495 no 1139 0.362281260691047 1680 3107280 SGTC_899 1083-0020 478 µM 0.352099415350646 0.336009236481192 no 1140 0.362381853417898 1810 767123 SGTC_1982 st072467 71.9 µM 0.348841051277797 0.337265058850246 no 1141 0.363604321261013 1668 3163533 SGTC_1875 nocodazole 6 µM 0.345948165062916 0.338381542623814 no 1142 0.36469083519721 1820 4122 A microtubule depolymerizer. YJL014W CCT3 SGTC_2262 9014885 67.46 µM 0.345834907813023 0.338425282249998 no 1143 0.364733394683209 1823 6457424 SGTC_2054 5233173 129 µM 0.344445931733124 0.338961877996602 no 1144 0.365255475586392 1740 6889 SGTC_3079 9117512 49.47 µM 0.343845882402364 0.33919379304861 no 1145 0.365481096252534 1765 7185044 SGTC_2592 piperlongumine 83.33 µM 0.343124002752273 0.339472875451336 no 1146 0.365752587236373 1646 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_1471 k673-0312 37 µM 0.342617075945886 0.33966890861513 no 1147 0.365943277028177 1758 24099884 SGTC_1990 st072050 59.8 µM 0.342576559323165 0.33968457863097 no 1148 0.365958519527044 1674 17233948 SGTC_3325 9138760 55.175 µM 0.339989547713935 0.340685691559629 no 1149 0.366932199645095 1658 43844959 SGTC_773 4358-1457 44.6 µM 0.339383671206551 0.340920314182371 no 1150 0.367160358961032 1869 1186886 SGTC_3283 9109332 35.8195 µM 0.339320099310154 0.340944935647542 no 1151 0.367184301412796 1685 17027281 SGTC_1061 3448-9325 110 µM 0.338295492866318 0.341341860230644 no 1152 0.367570259942363 1788 723482 SGTC_397 arbidol 50 µM 0.337279599615825 0.341735582749036 no 1153 0.367953068406214 1820 131410 A RNA synthesis inhibitor. SGTC_298 1391-0729 10 µM 0.337034095844696 0.341830756754524 no 1154 0.368045598728817 1721 3237558 SGTC_2876 9059903 25.97 µM 0.33637034480492 0.342088122246166 no 1155 0.368295804683391 1723 6916095 SGTC_1140 3229-1848 2.98 µM 0.336127127905453 0.342182446519592 no 1156 0.36838750111767 1828 2849525 SGTC_1256 0570-0116 285 µM 0.33487188963699 0.342669408935841 no 1157 0.3688608639289 1678 410638 SGTC_1636 st007707 68.9 µM 0.333609633971387 0.343159357497685 no 1158 0.369337073758042 1852 403051 SGTC_1934 st074720 32.6 µM 0.333309545676578 0.343275876565764 no 1159 0.369450317280039 1641 17250992 SGTC_1817 st052116 64.4 µM 0.332824927578502 0.343464076804746 no 1160 0.369633220236595 1792 4361398 SGTC_412 gemfibrozil 100 µM 0.331703965406532 0.3438995483578 no 1161 0.370056403049133 1755 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels. SGTC_1220 1838-0075 193 µM 0.328924992120081 0.344980016673492 no 1162 0.37110619173331 1772 5529645 SGTC_2249 haloperidol 116.36 µM 0.327686901846544 0.345461795684795 no 1163 0.371574203941679 1785 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_1833 st055984 71 µM 0.325507870100897 0.346310331924844 no 1164 0.372398363596951 1748 676288 SGTC_1111 tnp00062 510.699 nM 0.324440679796364 0.346726188161409 no 1165 0.372802212931785 1854 676306 SGTC_252 miconazole 1.30953 nM 0.324209722051165 0.346816210706887 no 1166 0.372889631072379 1801 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_1522 st012842 45.6 µM 0.323790705853015 0.346979556618284 no 1167 0.373048246562007 1637 3491067 YOR116C RPO31 SGTC_1711 st032263 62.8 µM 0.323582669378612 0.347060666454742 no 1168 0.373127005230783 1788 3958979 SGTC_660 4031-1742 102 µM 0.319650637560099 0.34859501202635 no 1169 0.374616591705633 1738 6738706 SGTC_1310 1188-0297 994 nM 0.319579942806548 0.348622621089304 no 1170 0.374643390472196 1790 1588352 SGTC_2016 5121758 140 µM 0.31909602811048 0.348811630204233 no 1171 0.374826847732584 1724 2795203 SGTC_3105 9121040 49.47 µM 0.318679566984474 0.348974323111924 no 1172 0.374984755303701 1844 41448907 SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM 0.318616266474114 0.348999054248061 no 1173 0.375008758490646 1769 4000243 SGTC_2081 5214970 32.255 µM 0.318436584822403 0.34906925830398 no 1174 0.375076895369557 1849 2063512 SGTC_3323 9138564 53.9225 µM 0.317706764904966 0.349354461917051 no 1175 0.375353689624134 1886 43912313 YNL103W MET4 SGTC_1241 0364-0022 50.8 µM 0.317130300068566 0.349579796619346 no 1176 0.375572367231966 1792 4563895 SGTC_2541 muurolladie-3-one 83.07 µM 0.316637529509671 0.349772458041832 no 1177 0.375759327741932 1789 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils.  YMR203W TOM40 SGTC_56 0957-0365 83.25 µM 0.315246735924091 0.350316433409584 no 1178 0.376287161544724 1825 6752360 SGTC_2187 6125751 200 µM 0.315231975860005 0.350322208101952 no 1179 0.376292764525301 1777 874498 SGTC_152 4469-0003 551.229 µM 0.314965841501288 0.350426335810731 no 1180 0.376393794685917 1881 697280 SGTC_418 lividomycin a 100 µM 0.314810989692445 0.35048692829163 no 1181 0.376452583564447 1863 72394 An antibiotic. SGTC_1642 st009582 77.7 µM 0.313151248487005 0.351136612613991 no 1182 0.377082877490967 1887 6739311 SGTC_3344 9148862 3.898 µM 0.313146677440929 0.351138402493081 no 1183 0.377084613818744 1847 4905352 SGTC_245 methotrexate 289.6 µM 0.311701292162341 0.351704535715638 no 1184 0.377633772924088 1821 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2 SGTC_2539 epi(13)torulosol 80 µM 0.311437774240797 0.351807786772731 no 1185 0.377733920519934 1707 6708597 SGTC_1030 k029-0042 36.7 µM 0.310397274864025 0.352215579848208 no 1186 0.378129433109756 1777 6080581 SGTC_205 1486-1330 71.903 µM 0.309821542244465 0.352441294367309 no 1187 0.378348334396435 1787 4118834 SGTC_2031 5180455 200 µM 0.309056206499188 0.352741422769418 no 1188 0.378639385788467 1757 29949 SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM 0.308843492831898 0.352824855275365 no 1189 0.378720291420318 1708 5355888 SGTC_3086 9117350 49.47 µM 0.308170491101655 0.353088872795675 no 1190 0.378976302588248 1745 2679265 SGTC_896 0964-0007 44.5 µM 0.307585744176169 0.353318325532826 no 1191 0.379198784573655 1872 6756758 SGTC_1505 k297-0037 20.6 µM 0.307159122773347 0.353485763995292 no 1192 0.379361128896445 1725 4089396 SGTC_3056 9094900 49.47 µM 0.305985794010338 0.353946412982164 no 1193 0.37980773105087 1677 25236784 SGTC_559 1550-0661 158 µM 0.305772559690619 0.354030151782215 no 1194 0.379888911308364 1811 5830875 SGTC_3319 9138450 16.7555 µM 0.304631472841478 0.354478385489278 no 1195 0.380323423388144 1777 2029690 SGTC_1402 3909-7673 35.9 µM 0.302435235769256 0.355341662896894 no 1196 0.381160148661578 1751 5328014 SGTC_799 1310-0557 151 µM 0.302255967143095 0.3554121610698 no 1197 0.381228471248937 1807 5354492 SGTC_3125 9127534 49.47 µM 0.301775014453901 0.355601322259802 no 1198 0.38141178949385 1835 1639235 SGTC_641 4092-0595 30 µM 0.300944212069713 0.355928164919405 no 1199 0.3817285178843 1853 786260 SGTC_2048 5246248 200 µM 0.300225652331563 0.356210936077959 no 1200 0.382002519674905 1893 677046 SGTC_737 1950-0117 57.9 µM 0.297650798074866 0.357224853896754 no 1201 0.382984849768586 1901 5393513 SGTC_1774 st048371 48.465 µM 0.296830030601505 0.35754826548364 no 1202 0.383298138539159 1732 4242727 SGTC_266 formosanin C 406 nM 0.296524993600474 0.357668487007831 no 1203 0.383414591308134 1832 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1 SGTC_1706 st031321 9.9705 µM 0.296499382267941 0.357678581617683 no 1204 0.383424369324702 1886 6103185 SGTC_528 3492-0019 172 µM 0.295655264318639 0.358011343188079 no 1205 0.383746682215474 1799 2869262 SGTC_74 000s-0487 160.283 µM 0.295250924067822 0.358170777276557 no 1206 0.383901101560853 1913 677548 SGTC_1798 st045719 60.953 µM 0.294602880913245 0.358426356643991 no 1207 0.384148630574654 1878 3980186 SGTC_739 1486-1183 203 µM 0.294451822661407 0.358485941075276 no 1208 0.38420633615152 1919 4346692 SGTC_2120 5538279 151.968 µM 0.29334091348903 0.358924241302116 no 1209 0.384630791967505 1804 2058197 SGTC_1278 0874-0585 172 µM 0.292272398707736 0.359345990484581 no 1210 0.385039180277807 1838 766306 SGTC_2886 9058944 51.95 µM 0.292007904722128 0.359450414332975 no 1211 0.38514029007652 1780 4949929 SGTC_529 4076-0302 30.3 µM 0.291640515621811 0.359595479219792 no 1212 0.385280747201525 1768 5816522 SGTC_793 0488-0545 106 µM 0.291623519283689 0.359602190773916 no 1213 0.385287245463588 1750 292548 SGTC_302 1094-0063 18.9 µM 0.29153029972103 0.359639002304941 no 1214 0.385322886957514 1796 5440289 SGTC_931 2812-0076 566 µM 0.290412859588009 0.360080370220727 no 1215 0.385750203451292 1759 3450959 SGTC_4 0960-0234 25.671 µM 0.290025557284874 0.36023339094785 no 1216 0.385898342803501 1783 6821112 SGTC_1484 3473-2379 286 µM 0.289431085998307 0.360468306408554 no 1217 0.386125754637322 1856 671917 SGTC_407 eburnamonine 100 µM 0.287488592791734 0.361236282579476 no 1218 0.386869117550243 1761 3195 SGTC_1560 lithocholic acid 53.1 µM 0.287470348554255 0.361243498203841 no 1219 0.386876101317685 1910 9903 A bile acid which acts as a detergent. SGTC_3284 9108171 64.8615 µM 0.286532323866193 0.361614554894914 no 1220 0.387235219961558 1814 8687505 SGTC_3097 9117246 49.47 µM 0.285711734081861 0.361939264341046 no 1221 0.387549458339783 1771 16423892 SGTC_2484 5809818 12.04 µM 0.285260413785563 0.362117895306889 no 1222 0.38772231930266 1794 2870548 SGTC_483 fpl-64176 144 µM 0.284344969633743 0.362480317053689 no 1223 0.388073013463655 1833 3423 SGTC_1059 3448-6867 171 µM 0.283196583718996 0.362935134072579 no 1224 0.388513073503802 1972 3934407 SGTC_2946 9065502 71.43 µM 0.282983817161113 0.36301942129564 no 1225 0.388594621114219 1824 16489101 SGTC_2341 7987486 176.74 µM 0.28056422938035 0.36397840404672 no 1226 0.389522327611472 1952 1258686 SGTC_982 1491-0518 27.5 µM 0.279548847846922 0.364381096056627 no 1227 0.389911828174429 1818 3091256 SGTC_1971 st069429 63.5 µM 0.278617546305259 0.364750574298775 no 1228 0.390269172863988 1931 1246522 YGL099W LSG1 SGTC_594 1487-1584 10.8 µM 0.278392053766114 0.364840053583638 no 1229 0.390355709345412 1741 5013332 SGTC_392 N-ethylmaleimide 8.33 µM 0.278176745266791 0.36492549853891 no 1230 0.390438342603663 1774 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides. SGTC_2574 2',4'-dihydroxychalcone 14.64 µM 0.277909445327942 0.365031585576566 no 1231 0.390540936544723 1947 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_3263 9137018 49.47 µM 0.276232240864042 0.365697476499937 no 1232 0.391184847796848 1712 43844957 SGTC_862 0452-0056 10.2 µM 0.274263168821468 0.366479762572474 no 1233 0.391941193336167 1911 1575396 YLR359W | YHR072W ADE13 | ERG7 SGTC_3069 9117009 49.47 µM 0.27398561563027 0.366590075464616 no 1234 0.392047837952879 1931 41904981 SGTC_1988 st071872 53.4 µM 0.273277501649981 0.366871563684677 no 1235 0.39231995421313 1960 16414116 SGTC_2186 6124449 200 µM 0.273101423155302 0.366941569218236 no 1236 0.392387626389587 1893 3834182 YLR033W RSC58 SGTC_2312 7706453 155.7 µM 0.272841490814583 0.367044921568017 no 1237 0.392487532028054 1798 976098 SGTC_1433 4060-0023 7.6 µM 0.271334635275552 0.367644255812678 no 1238 0.393066835085681 1887 3840627 SGTC_819 1013-0258 27.7 µM 0.271262713412117 0.367672869970807 no 1239 0.393094491018706 1822 5753198 SGTC_1355 1499-0035 1.68 µM 0.270835921768141 0.367842684399517 no 1240 0.3932586152312 1804 1548538 SGTC_1609 st001574 46.4 µM 0.270586582114202 0.36794190511986 no 1241 0.393354508444651 1778 3960012 SGTC_3206 9114350 49.47 µM 0.269617196868287 0.368327740116549 no 1242 0.393727384479676 1908 17087243 SGTC_2770 toltrazuril 17.5 µM 0.26946197504204 0.368389533899993 no 1243 0.393787099936941 1946 68591 Kills coccidiodes. SGTC_2976 9009005 19.48 µM 0.268859826396723 0.368629281381866 no 1244 0.394018776434501 1980 2993148 SGTC_1283 0922-0125 16.4 µM 0.268532007463582 0.368759825085271 no 1245 0.39414492043779 1888 3360884 SGTC_347 4534-1311 26.2 µM 0.267684808612198 0.369097265813276 no 1246 0.394470972092328 1805 2862016 SGTC_914 3820-6779 408 µM 0.266462736246904 0.369584196998161 no 1247 0.394941427211937 1804 2893481 SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM 0.265530799413099 0.369955665192118 no 1248 0.395300293309069 1849 364106 SGTC_2158 5657123 3.6195 µM 0.264958740406333 0.370183746926534 no 1249 0.395520623261126 1926 2858827 SGTC_1312 1218-2183 165 µM 0.263829571688075 0.370634083998175 no 1250 0.395955623367633 1922 6744073 SGTC_2075 5212009 200 µM 0.263732305699885 0.370672884095164 no 1251 0.395993100114106 1926 780898 SGTC_1818 st052136 56.3 µM 0.263361830500284 0.370820681339841 no 1252 0.396135853624262 1813 674169 SGTC_3127 9126946 49.47 µM 0.26286217355708 0.3710200444911 no 1253 0.396328406201251 1766 27243249 SGTC_2086 5274770 176.623 µM 0.259965332455408 0.372176564986916 no 1254 0.397445257553896 1837 689278 SGTC_511 blebbistatin 171 µM 0.257215201658088 0.373275581695262 no 1255 0.398506324741941 1936 3476986 A myosin inhibitor. SGTC_1498 4478-3555 97.6 µM 0.256810013367297 0.373437591848924 no 1256 0.398662719857127 1976 3437919 SGTC_1754 st042065 16.137 µM 0.256484934171872 0.373567587424718 no 1257 0.398788206124676 1883 1126236 YIL048W NEO1 SGTC_2583 asiatic acid 100 µM 0.256358211522473 0.373618266309248 no 1258 0.398837126123658 1871 5320556 A kinase inhibitor; arrests cells at G2/M. SGTC_859 0439-0102 54.6 µM 0.25377480378199 0.374651897257564 no 1259 0.399834770005862 1992 610143 SGTC_264 promethazine 12.5 mM 0.253010078939487 0.37495803970163 no 1260 0.400130212338341 1985 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3 SGTC_759 3486-0358 89.3 µM 0.251906139046774 0.375400119120165 no 1261 0.40055680715312 2001 875103 SGTC_2332 7982454 138.89 µM 0.251584752480692 0.37552885110506 no 1262 0.400681022686896 1913 2981748 SGTC_1412 3909-8563 178 µM 0.249618778031486 0.376316627027828 no 1263 0.401441087718697 1985 23767530 SGTC_796 1234-0020 70.7 µM 0.24836652890094 0.376818678582818 no 1264 0.401925414212221 1821 46495034 SGTC_2374 9071832 200 µM 0.24830933878666 0.37684161221771 no 1265 0.401947536965923 1962 17381698 SGTC_2636 apigenin dimethyl ether 100 µM 0.247868501704328 0.377018405543566 no 1266 0.402118075756642 1892 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_2173 5763948 167 µM 0.247154851617747 0.377304662456683 no 1267 0.40239419234531 1960 2867177 SGTC_2839 9003951 25.97 µM 0.246407077317012 0.377604679501953 no 1268 0.402683564102395 2036 2990634 SGTC_2927 9011802 47.9 µM 0.245266160347368 0.378062572910766 no 1269 0.403125175882981 1787 43912568 SGTC_374 0880-0231 82.3 µM 0.245180263222429 0.37809705364017 no 1270 0.4031584288705 1935 6833587 SGTC_2515 chrysin 20.77 µM 0.245103935481941 0.378127693852578 no 1271 0.403187977890691 1952 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor. SGTC_1344 1488-0097 29.1 µM 0.244853168019468 0.378228364723555 no 1272 0.403285062250016 1893 747966 SGTC_2026 5148700 152 µM 0.244436267450542 0.378395748205565 no 1273 0.403446478057456 1853 79838 SGTC_3305 9127027 53.8275 µM 0.244418853046092 0.378402740498129 no 1274 0.403453220934914 1867 41905295 SGTC_138 0850-0259 40.9225 µM 0.24417229956681 0.378501741784692 no 1275 0.403548689804799 1960 6813004 SGTC_97 0535-0701 19.132 µM 0.242897475865305 0.379013762632422 no 1276 0.404042410497072 1820 2832013 YGL099W LSG1 SGTC_3058 9093861 49.47 µM 0.242741629862969 0.379076371286274 no 1277 0.404102777892801 1919 17217477 SGTC_1086 cerivastatin 2.18 µM 0.242732180225387 0.379080167629971 no 1278 0.404106438310454 1978 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7 SGTC_1691 st019933 84.6 µM 0.241494166600452 0.379577634017806 no 1279 0.4045860685492 2023 6176082 SGTC_80 0159-0065 512.242 µM 0.241325727249344 0.379645332801516 no 1280 0.404651336285853 1987 1548079 SGTC_1782 st039423 80.636 µM 0.240303722990876 0.380056173603526 no 1281 0.405047404517058 1824 2068169 SGTC_2436 5633522 8.09 µM 0.240295787161589 0.380059364299081 no 1282 0.405050480354918 2005 5724242 SGTC_1718 roemerine 11.9335 µM 0.239478957477766 0.380387824118128 no 1283 0.405367105660262 1944 235224 An aporphine alkaloid with mutagenic activity. SGTC_1946 st076057 65.1 µM 0.239267552348354 0.380472847443692 no 1284 0.405449062111572 1874 953009 SGTC_2855 9016525 58.44 µM 0.239251035519431 0.380479490457278 no 1285 0.405455465445351 1898 43811474 SGTC_447 ml7 120 µM 0.237543571408159 0.381166416654911 no 1286 0.406117560602822 2006 4216 Selective myosin light chain kinase inhibitor. SGTC_2438 5259590 200 µM 0.236936792004406 0.381410619094932 no 1287 0.406352913318085 1978 1201127 SGTC_2552 juarezic acid 87.02 µM 0.235475728460476 0.381998827486118 no 1288 0.406919757575876 2024 1549512 SGTC_2817 7995342 71.43 µM 0.234091989455265 0.382556157136858 no 1289 0.40745678233485 1826 18879975 SGTC_2493 resveratrol 26.09 µM 0.233244242454849 0.382897725147562 no 1290 0.407785876289681 1871 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase. SGTC_1838 st055369 84.5 µM 0.232348645841969 0.383258671315091 no 1291 0.408133616071176 1979 676036 SGTC_2137 5261020 140 µM 0.2321936798301 0.383321136500871 no 1292 0.408193793198415 1892 763655 SGTC_2823 7987624 58.44 µM 0.229947519450453 0.384226880221723 no 1293 0.409066275174718 1906 2239440 SGTC_1062 mesoridazine 14.2 µM 0.229733350177586 0.38431327514102 no 1294 0.409149489112008 1912 4078 A neuroleptic. SGTC_2066 5222451 176 µM 0.229675968450972 0.38433642364732 no 1295 0.409171785066573 1934 2281147 SGTC_2403 6032726 181.2 µM 0.227108929428599 0.385372420156003 no 1296 0.410169520389335 1883 2881040 SGTC_571 k831-0106 44.2 µM 0.226905510796955 0.385454550222441 no 1297 0.410248608409109 2030 4783639 SGTC_2482 5981709 142.65 µM 0.225011409002796 0.386219538046316 no 1298 0.410985199368158 1936 877755 SGTC_2464 5717415 7.67 µM 0.224778644641705 0.386313577261858 no 1299 0.411075740042877 1829 5285744 SGTC_2667 digitoxin 100 µM 0.224219425627394 0.386539534829266 no 1300 0.411293284393158 2035 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_2861 9024595 19.48 µM 0.222884427621194 0.387079108436252 no 1301 0.411812728254403 2041 16482810 SGTC_1167 k781-0610 148 µM 0.222590795488247 0.387197816697993 no 1302 0.411927000437874 1898 4525169 SGTC_1490 4089-0339 670 nM 0.221129917311718 0.387788570483201 no 1303 0.412495638079765 2016 742542 SGTC_2925 9010536 32.5 µM 0.220445909727307 0.388065260675754 no 1304 0.412761946950348 1952 2994177 SGTC_2007 4011539 71.82 µM 0.218567478024357 0.388825403308085 no 1305 0.413493494513437 1893 45595301 SGTC_2167 5876490 200 µM 0.21760041702767 0.389216908918652 no 1306 0.413870229767664 2038 686534 SGTC_256 clotrimazole 625 nM 0.217544172052 0.389239682637014 no 1307 0.413892143408906 1976 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C SGTC_2723 salbutamol 83.58 µM 0.214476093078133 0.390482529205918 no 1308 0.415087904080962 2010 9884233 β2-adrenoceptor agonist SGTC_2650 prasterone 100 µM 0.214470171257139 0.390484929160317 no 1309 0.415090212830625 1968 16759247 A steroid and weak partial agonist of the androgen receptor. SGTC_910 3454-3003 490 µM 0.212822477076027 0.3911528569815 no 1310 0.415732715586756 2062 820824 SGTC_600 1495-0418 41.6 µM 0.212382642497085 0.391331207654265 no 1311 0.41590426309327 1934 5377768 SGTC_2635 hydroquinidine 100 µM 0.212274276649592 0.39137515296115 no 1312 0.415946531197237 1918 442912 An experimental heart treatment. SGTC_547 1120-0019 610 nM 0.211422507776231 0.391720616709872 no 1313 0.416278797505902 1909 3676939 SGTC_1635 st007035 42.4 µM 0.210023285072234 0.392288304184675 no 1314 0.416824749729467 1971 3716403 SGTC_2913 7966556 36.57 µM 0.20910412667563 0.392661346611283 no 1315 0.417183476647419 2022 2976516 SGTC_1250 0485-0349 40.2 µM 0.20693153194145 0.39354349040166 no 1316 0.418031665260573 1919 6842794 YDL195W SEC31 SGTC_1783 st039459 87.517 µM 0.206639237373362 0.393662213280792 no 1317 0.418145807279639 2047 729761 SGTC_72 0744-0168 198.391 µM 0.206500612078207 0.393718522929854 no 1318 0.418199943337837 1940 677577 SGTC_35 0133-0054 64.071 µM 0.206134095720662 0.393867412720797 no 1319 0.418343083053843 1871 99677 SGTC_939 1165-0479 45.3 µM 0.206084735583415 0.393887465455217 no 1320 0.418362361044818 2073 1377347 SGTC_1574 spiramycin 23.7 µM 0.205783867330982 0.394009700354111 no 1321 0.418479871753165 1965 6419898 An antibiotic and protein synthesis inhibitor. SGTC_2198 6589944 200 µM 0.20570463382921 0.394041892590271 no 1322 0.418510819349392 1984 5290268 SGTC_1697 st025554 27.742 µM 0.2039862102423 0.394740258578901 no 1323 0.419182137491396 1926 1269519 SGTC_1840 st055363 71 µM 0.203810927271902 0.394811512494871 no 1324 0.419250626672598 1866 676033 SGTC_3016 9080866 49.47 µM 0.203525865791892 0.39492739975782 no 1325 0.419362015377714 1957 17066299 SGTC_419 nsc-638432 893 µM 0.203177721226874 0.395068945066113 no 1326 0.419498062769796 1942 368090 SGTC_1644 st010134 20.9 µM 0.196160016522758 0.397925065535902 no 1327 0.422242461110839 2077 3818134 SGTC_2241 6772625 37.8075 µM 0.195355255937778 0.398252946366272 no 1328 0.422557421139614 2110 2285411 SGTC_585 0kpi-0023 191 µM 0.194853179007093 0.398457542252028 no 1329 0.422753944633354 2053 64601 SGTC_1704 st028805 70.8 µM 0.194735710492943 0.398505414594641 no 1330 0.422799927063095 1955 2876101 SGTC_2371 9071574 200 µM 0.194638964365144 0.398544843019745 no 1331 0.422837798614024 2065 45596039 SGTC_1400 3771-8998 51.5 µM 0.194494825458545 0.398603588067615 no 1332 0.422894223527623 2009 670767 SGTC_3122 9126309 49.47 µM 0.194103472425269 0.398763098937304 no 1333 0.423047431367792 2104 17591206 SGTC_1750 st081859 2.357 µM 0.193800098295716 0.398886762283321 no 1334 0.423166205021289 1961 5291695 SGTC_624 k048-0052 28 µM 0.193110520391814 0.399167890276732 no 1335 0.423436206826865 1960 6835531 SGTC_322 k048-0136 19.3 µM 0.192958150723313 0.399230015596703 no 1336 0.423495871489911 1999 6823282 SGTC_2601 securinine 100 µM 0.192764156388576 0.399309116135261 no 1337 0.42357183800933 1932 442872 A GABA receptor antagonist. SGTC_1604 st002052 72.4 µM 0.192360172663222 0.399473852407521 no 1338 0.423730043689553 1989 6254834 YHR062C RPP1 SGTC_3115 9123671 49.47 µM 0.191363235640647 0.399880459396456 no 1339 0.424120510733489 2117 3286988 SGTC_1786 berberine 21.6 µM 0.190375740222173 0.40028332261769 no 1340 0.42450735326085 1979 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_3215 9129942 49.47 µM 0.190152120046813 0.400374566496314 no 1341 0.424594964584074 2096 17682944 SGTC_1272 0839-0021 27 µM 0.189321469685983 0.400713544852458 no 1342 0.424920434611135 1988 5027250 SGTC_3261 9137475 49.47 µM 0.188863527951892 0.400900457324648 no 1343 0.425099889781541 2089 17027690 SGTC_234 nsc-17383 10.7 µM 0.187885129151094 0.401299874355104 no 1344 0.42548335017662 2061 408974 SGTC_2766 oltipraz 83.91 µM 0.18754069705059 0.401440508305423 no 1345 0.425618359031556 2056 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40 SGTC_844 0330-0132 15.3 µM 0.186963439455638 0.401676235098095 no 1346 0.425844649264093 2062 2828079 SGTC_2172 5754775 163.918 µM 0.185793688882596 0.402154019779703 no 1347 0.426303276953536 1930 2263357 SGTC_1513 0337-0559 19 µM 0.184746704207002 0.402581784771079 no 1348 0.426713856000953 1905 775073 SGTC_3235 9132602 49.47 µM 0.184321174273241 0.402755676283697 no 1349 0.426880751918066 2000 4912240 SGTC_2467 5474540 200 µM 0.183997862944164 0.402887809338186 no 1350 0.427007565712443 2056 5413519 SGTC_295 k015-0027 31 µM 0.183345309275451 0.403154533143348 no 1351 0.427263542613611 2017 3887424 SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM 0.183027361124589 0.403284507127808 no 1352 0.427388275079144 1929 2374 Ca(2+)-ATPase inhibitor. SGTC_147 4466-0538 29.23 µM 0.182974500548535 0.403306117032261 no 1353 0.427409013220931 1989 6742687 YHR072W ERG7 SGTC_1138 3761-0006 1.03 µM 0.18248406404959 0.403506626190887 no 1354 0.427601429716535 2077 12061087 SGTC_157 1348-1695 65.819 µM 0.181839441339004 0.403770211131803 no 1355 0.427854365389364 2028 5380510 SGTC_1424 4048-1941 275 µM 0.180656523510925 0.404254017486135 no 1356 0.428318593196677 2084 X1424 SGTC_1766 st045414 44.774 µM 0.180106523584931 0.404479014111449 no 1357 0.42853447063927 2029 253960 SGTC_2353 9059630 146.67 µM 0.178584074969479 0.405101989289264 no 1358 0.42913214989837 2060 4779114 SGTC_3220 9131269 49.47 µM 0.178230924435492 0.40524653041186 no 1359 0.429270812166615 2084 17722206 SGTC_1200 1643-0193 18.4 µM 0.176458733590347 0.405972065897046 no 1360 0.429966782873506 2102 5403974 SGTC_3185 9108267 49.47 µM 0.176383162032079 0.40600301211608 no 1361 0.429996466015949 1949 4910486 SGTC_1343 1487-0095 224 µM 0.176355975200512 0.406014145147084 no 1362 0.430007144608881 2102 4560101 YGL055W OLE1 SGTC_2819 7996655 46.38 µM 0.175906703302002 0.406198133376711 no 1363 0.430183619499485 2067 6456960 SGTC_1254 0550-0035 264 µM 0.175558969319943 0.406340553480439 no 1364 0.430320219672692 2037 15121435 SGTC_847 0342-0274 5.54 µM 0.175232326242087 0.406474346749653 no 1365 0.430448542312451 2086 18097 SGTC_201 4262-0159 12.803 µM 0.174432742447023 0.406801902970194 no 1366 0.430762691995382 2094 1341029 SGTC_2517 totarol 10 µM 0.173720408920152 0.407093771318119 no 1367 0.431042598702152 1925 460178 An antibacterial membrane disruptor. YGL001C ERG26 SGTC_2740 felodipine 17.08 µM 0.173474861674027 0.40719439271379 no 1368 0.431139092889535 2114 3333 L-type calcium channel blocker SGTC_1213 1315-0166 115 µM 0.171380644638107 0.408052818117166 no 1369 0.431962236479688 1866 768401 SGTC_2512 diallyl trisulfide 49.23 µM 0.171149954699936 0.408147405637487 no 1370 0.432052928567 2123 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent SGTC_933 2914-0560 114 µM 0.170400580671454 0.408454700987964 no 1371 0.43234755775546 2154 463887 SGTC_651 3253-0966 34.4 µM 0.168288651238664 0.409321040928215 no 1372 0.433178100767765 2013 781462 SGTC_1802 st050112 57.9 µM 0.166970578582944 0.409861955684979 no 1373 0.43369659940108 2103 4662563 SGTC_2362 9071156 126 µM 0.165617765879733 0.410417305601512 no 1374 0.434228882614978 2085 653133 SGTC_165 k038-0023 64.381 µM 0.165603327654198 0.41042323368079 no 1375 0.434234564183147 2019 46368543 SGTC_2349 9023730 187.07 µM 0.164366377966454 0.410931179127468 no 1376 0.434721365030959 2075 4126287 SGTC_2087 5276107 200 µM 0.163968422936549 0.411094628607954 no 1377 0.434878001087224 2075 144405 SGTC_1322 1348-1070 12 µM 0.163849814302583 0.411143346947651 no 1378 0.434924687708886 2097 6758089 SGTC_262 fenpropimorph 62.5 µM 0.163787637090248 0.411168886703028 no 1379 0.434949162208676 2099 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_1244 0416-0015 52.5 µM 0.16240585245081 0.411736562052656 no 1380 0.435493131216831 2001 96201 SGTC_1758 st042942 75.2445 µM 0.159855237420144 0.412784909795155 no 1381 0.436497555168836 2136 669317 SGTC_1328 1441-0025 69.2 µM 0.159588613508724 0.412894532980863 no 1382 0.43660257456003 2103 4562601 SGTC_1716 st033144 30.6155 µM 0.158512733187133 0.413336953186982 no 1383 0.437026393938666 2128 674617 SGTC_1384 3089-0840 101 µM 0.157656173906774 0.413689263592457 no 1384 0.4373638683258 2120 1069836 SGTC_2620 irigenin 100 µM 0.15714193954517 0.413900806132765 no 1385 0.437566492588739 2077 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro. SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM 0.157014042260336 0.413953423606514 no 1386 0.437616890624336 1966 6708561 SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM 0.156564342751306 0.414138444109241 no 1387 0.437794103134559 2025 115019 SGTC_3100 9120536 49.47 µM 0.156363092282245 0.414221251048541 no 1388 0.437873413692954 2140 16421196 SGTC_2957 9076800 11.52 µM 0.156020788821862 0.414362104703898 no 1389 0.438008317388235 1993 16459615 SGTC_2194 5927483 104.545 µM 0.155273038668576 0.414669832962144 no 1390 0.438303034916318 2115 760979 SGTC_1434 4073-0095 163 µM 0.153845097718511 0.415257631534221 no 1391 0.438865937128049 2116 24133745 SGTC_839 0122-0028 230 µM 0.153061424486884 0.415580304026768 no 1392 0.439174918078883 2055 759448 SGTC_1107 amlodipine 47 µM 0.151923508314046 0.416048935106887 no 1393 0.4396236332789 2083 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.  SGTC_949 1165-0505 146 µM 0.151373703227095 0.416275405635661 no 1394 0.439840466096917 1985 6244267 SGTC_2935 9038016 29.96 µM 0.150918602285859 0.416462887558094 no 1395 0.440019963029989 2155 6463195 SGTC_1666 st014829 29 µM 0.1499154892505 0.416876193839955 no 1396 0.440415645584941 2058 3858230 SGTC_2338 7999974 200 µM 0.148394819654255 0.417502920759542 no 1397 0.441015594063956 2156 315925 SGTC_921 1561-0023 372 µM 0.147449760987249 0.417892521815832 no 1398 0.441388515561619 2163 24050882 SGTC_2288 7946289 167.31 µM 0.146636679696525 0.418227779626563 no 1399 0.441709400200678 2142 1246052 SGTC_1811 st050069 61.5 µM 0.145553185264814 0.418674629200098 no 1400 0.442137063514504 2177 3877702 SGTC_2139 5578692 56.4705 µM 0.143648357471109 0.419460463255821 no 1401 0.44288907644131 2177 650991 YMR113W FOL3 SGTC_2550 chrysin dimethyl ether 71.87 µM 0.14322806840588 0.419633896306296 no 1402 0.44305503148395 2137 88881 An O-methylated flavonoid and antioxidant. SGTC_3146 9095609 49.47 µM 0.143097079432292 0.419687952338132 no 1403 0.443106755740655 2073 17173999 SGTC_1104 tacrolimus 29.8 µM 0.140580729437091 0.420726683113328 no 1404 0.444100586357751 2131 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41 SGTC_2521 angolensin 13.4 µM 0.140295892584895 0.42084429659531 no 1405 0.444213104736145 2073 821428 A flavenoid. SGTC_2962 9082311 13.18 µM 0.139505152531294 0.421170842229709 no 1406 0.444525492311884 2057 16459453 SGTC_93 0109-0045 59.227 µM 0.138218772954839 0.421702183959849 no 1407 0.445033759412806 2187 88733 SGTC_696 1560-0013 611 µM 0.136881527074304 0.422254687265816 no 1408 0.445562220321824 2131 1650269 SGTC_1935 st074532 41.6 µM 0.13572700596605 0.422731818207132 no 1409 0.446018548800353 2167 2829742 SGTC_287 k060-0039 29.6 µM 0.134459377190947 0.42325582391467 no 1410 0.446519665818956 2180 5861974 SGTC_3089 9117425 49.47 µM 0.13383145241019 0.423515442500067 no 1411 0.446767927743934 2007 9401657 SGTC_410 α-linolenic acid 100 µM 0.132667289356763 0.42399685920789 no 1412 0.447228256726176 2133 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_248 streptozotocin 5.23457 mM 0.131243872005366 0.424585639509394 no 1413 0.447791195623141 2184 5300 DNA alkylating agent. SGTC_947 3447-0010 211 µM 0.130468544305567 0.424906415833582 no 1414 0.44809786970069 2162 748350 SGTC_1699 st031318 29.054 µM 0.130134085180665 0.42504480697094 no 1415 0.448230171665264 2142 5340658 SGTC_858 0438-0351 2.77 µM 0.129865912369725 0.425155777100408 no 1416 0.448336256919242 2062 2799119 SGTC_1487 3970-0795 2.82 µM 0.129548630514695 0.425287076250742 no 1417 0.448461773765909 2107 3765103 SGTC_744 1594-0068 283 µM 0.128840786066852 0.425580029795561 no 1418 0.448741815928653 2091 668392 SGTC_1652 st011932 78 µM 0.12689378087578 0.426386042698084 no 1419 0.449512234496603 2167 1551076 SGTC_716 1683-5115 658 µM 0.125732247594473 0.426867035981579 no 1420 0.449971937266494 2202 723597 SGTC_2207 7258803 200 µM 0.12543551816439 0.426989929709608 no 1421 0.450089385364996 2165 3666799 SGTC_795 0685-0265 78 µM 0.124762609446974 0.42726864842994 no 1422 0.450355744690627 2219 302754 SGTC_2856 9022925 19.48 µM 0.124379218689377 0.427427465087219 no 1423 0.45050751332643 2116 4944862 SGTC_1340 1486-1359 257 µM 0.123550666575328 0.427770726535811 no 1424 0.450835527730316 2082 4309068 SGTC_2174 5790901 200 µM 0.121821740089892 0.428487180515789 no 1425 0.451520098041237 2098 786020 SGTC_3210 9128157 49.47 µM 0.121547072007363 0.428601022641746 no 1426 0.451628866491419 1931 17590849 SGTC_2039 Aminomethylbenzodioxan 200 µM 0.120648287508094 0.428973584791159 no 1427 0.45198481013143 2113 15053 SGTC_2965 9082772 38.63 µM 0.120462166236612 0.429050743287148 no 1428 0.452058524161065 2213 16459634 SGTC_3071 9117417 49.47 µM 0.120179185451383 0.42916806108903 no 1429 0.452170602931283 2189 45595590 YGL055W OLE1 SGTC_1907 st060210 83.7 µM 0.119104112809582 0.429613820246509 no 1430 0.452596436194721 2167 688793 SGTC_778 3456-2434 196 µM 0.117561432219683 0.430253621128187 no 1431 0.453207582798759 2198 5539063 SGTC_2988 9073640 71.4286 µM 0.116718877507967 0.430603133997311 no 1432 0.45354141521842 2141 9102229 SGTC_2367 9070478 135.38 µM 0.11665630660559 0.430629092152199 no 1433 0.453566208031633 2127 572802 SGTC_545 4218-0007 221 µM 0.116283331826431 0.43078383062618 no 1434 0.453713997633431 2124 2840508 SGTC_912 3474-0017 2.18 µM 0.114462039490635 0.431539594246774 no 1435 0.454435768338051 2162 3360550 SGTC_1920 st075728 45.7 µM 0.113585814274105 0.431903282220105 no 1436 0.454783066567488 2213 3400306 SGTC_2789 5281112 71.43 µM 0.112770614211167 0.432241692797325 no 1437 0.455106208079347 2077 765948 SGTC_150 3970-0969 77.2 µM 0.112269812116405 0.432449613336445 no 1438 0.455304738444184 2091 6615640 SGTC_390 dec-rvkr-cmk 16.7 µM 0.111902216235214 0.432602241886659 no 1439 0.45545046967054 2137 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1 SGTC_1846 st056244 14.8 µM 0.109745540869735 0.433497911434053 no 1440 0.456305591065798 2131 5393182 SGTC_1456 k015-0012 13 µM 0.108709884665932 0.433928142250407 no 1441 0.456716300747422 2232 2989616 SGTC_2971 9092186 9.93 µM 0.108294364662342 0.434100779009016 no 1442 0.456881096337966 1952 25236400 SGTC_368 fentichlor 4.58 µM 0.108218850340394 0.434132154415495 no 1443 0.456911046180082 2092 7329 A pesticide. SGTC_685 1278-0033 54.9 µM 0.106936888279096 0.434664859326784 no 1444 0.457419524176905 2193 3590572 SGTC_1097 itavastatin 7.23 µM 0.10646667354099 0.434860281559857 no 1445 0.457606047875758 2218 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49 SGTC_2038 4100038 30.985 µM 0.104632869454268 0.435622566016452 no 1446 0.458333565900688 2146 3596803 SGTC_1922 5578187 25 µM 0.104073514708597 0.435855129023903 no 1447 0.458555504450092 2217 1350412 SGTC_789 1309-1135 70.6 µM 0.101142740330214 0.43707401830825 no 1448 0.459718575053651 2234 3092424 SGTC_2264 7948757 110.76 µM 0.100645944491776 0.437280691892446 no 1449 0.459915761710393 2213 2971411 SGTC_879 0831-1030 162 µM 0.100492452017376 0.437344550238453 no 1450 0.459976687461213 2215 1549252 SGTC_2160 5660466 132.927 µM 0.100385179934518 0.437389180221497 no 1451 0.460019267515135 2233 2859134 SGTC_2318 6029776 164 µM 0.100121030814168 0.437499081461774 no 1452 0.460124119523817 2171 818325 SGTC_3112 9123419 49.47 µM 0.0991233655085754 0.437914211093174 no 1453 0.460520160226085 2253 17015854 SGTC_2502 avocadyne acetate 18.59 µM 0.0990185474049513 0.437957829996428 no 1454 0.46056177188709 2234 3952079 SGTC_2293 7624732 200 µM 0.0979314849185848 0.438410243470938 no 1455 0.460993349397377 2224 894453 SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM 0.0977992340860886 0.438465289103216 no 1456 0.461045857790056 2161 676296 Flavone; oxidizing agent. SGTC_1202 1988-0068 29.6 µM 0.0965435259631263 0.438988000912608 no 1457 0.461544453315602 2092 2850480 SGTC_592 k241-0073 46.5 µM 0.0958147826347616 0.43929140270658 no 1458 0.461833838266769 2234 4230158 SGTC_2865 9030313 51.95 µM 0.0954602206494445 0.43943903239424 no 1459 0.461974642622555 2188 42562754 SGTC_1337 1486-1011 40.3 µM 0.094197907013856 0.439964692698767 no 1460 0.462475973672001 2256 X1337 SGTC_2507 purpurin 79.67 µM 0.0934871771746901 0.440260705766319 no 1461 0.462758268106192 2221 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1 SGTC_471 1-acyl-paf 4 µM 0.0933833417566794 0.440303955153947 no 1462 0.462799512018398 2196 16759367 SGTC_581 0958-0271 211 µM 0.093270633828901 0.440350900913427 no 1463 0.462844280585484 2202 4591145 SGTC_1143 3454-2408 5.08 µM 0.0929450532158697 0.440486518345144 no 1464 0.462973606671991 2248 X1143 SGTC_308 4092-1169 104 µM 0.0915723766347865 0.441058369978957 no 1465 0.463518899732229 2195 2268590 YDL196W YDL196W SGTC_2793 7325131 81.82 µM 0.0894000109612742 0.441963619655758 no 1466 0.464382007380854 2174 4176441 SGTC_1530 rhein 70.4 µM 0.0888973276873432 0.442173136905987 no 1467 0.464581753670884 2241 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death. SGTC_3021 9087658 49.47 µM 0.0883981822566807 0.442381195598229 no 1468 0.464780102995465 2253 25237042 SGTC_431 k089-0097 107 µM 0.0883124135293977 0.442416948161789 no 1469 0.4648141864681 2253 5499420 SGTC_2813 7971799 71.43 µM 0.0866543468495229 0.443108202560757 no 1470 0.465473132893351 2188 2234054 SGTC_2611 pyromycin 23.93 µM 0.0859198911724725 0.443414455442042 no 1471 0.465765049556233 2167 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release. SGTC_2734 clemastine 41.6 µM 0.0849707677854418 0.443810270375292 no 1472 0.466142315283293 2267 26987 Clemastine is a selective histamine H1 antagonist. SGTC_3117 9124945 49.47 µM 0.0847418908162564 0.443905727825995 no 1473 0.466233295835624 2136 17592065 SGTC_747 3448-8087 38.7 µM 0.0844904021284429 0.444010619672365 no 1474 0.46633326677402 2181 5168703 SGTC_2836 9010338 19.48 µM 0.0825552214276332 0.444817882773568 no 1475 0.467102603899697 2162 2994051 SGTC_2617 dihydrotanshinone i 20.83 µM 0.0816749778322361 0.445185153461873 no 1476 0.467452588331192 2224 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12 SGTC_2254 7938975 95.19 µM 0.0808829467518994 0.445515658802578 no 1477 0.467767521023213 2250 2969277 SGTC_3183 9108214 49.47 µM 0.0806781415740011 0.445601127788226 no 1478 0.467848960317917 2246 4974831 SGTC_938 3126-1755 342 µM 0.0806106659352497 0.445629287173146 no 1479 0.46787579181152 2263 1777771 SGTC_801 0866-0028 10.1 µM 0.0803647359126212 0.445731922655876 no 1480 0.467973586411824 2258 6849771 SGTC_689 0833-0039 98 µM 0.0796411295683603 0.446033930791247 no 1481 0.468261341212688 2247 5374726 SGTC_2171 5739187 198.077 µM 0.0786835979124552 0.446433619323709 no 1482 0.468642145998424 2244 2262761 SGTC_1683 st010134 710 nM 0.07825603184945 0.446612109617662 no 1483 0.468812195828651 2255 3818134 SGTC_1624 st003710 6.25 µM 0.0780791800959969 0.44668594072157 no 1484 0.468882534251763 2254 24207033 SGTC_3131 9127911 49.47 µM 0.0780738266863798 0.446688175662602 no 1485 0.46888466345356 2213 45595681 SGTC_1643 st009866 20.2 µM 0.0774207871464543 0.446960819239801 no 1486 0.469144402330243 2260 3156273 YOR207C RET1 SGTC_3279 9140807 49.47 µM 0.0772773893647609 0.447020691080416 no 1487 0.469201438891279 2244 45595718 SGTC_472 calcifediol 10 µM 0.07671823062739 0.447254164112974 no 1488 0.469423850669809 2172 5283731 A vitamin D metabolite. SGTC_893 0958-0369 48.9 µM 0.0755230584746823 0.4477532615313 no 1489 0.469899275957609 2285 6819948 SGTC_1049 3226-0134 66 µM 0.0746604868867656 0.448113518200892 no 1490 0.470242423392709 2262 5702385 SGTC_391 gliotoxin 8.33 µM 0.073992693237096 0.448392454449949 no 1491 0.470508099638248 2225 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM 0.0733240321398467 0.448671778596098 no 1492 0.470774134144136 2214 4330530 SGTC_1794 st048918 76.9 µM 0.0721484767504563 0.449162912596836 no 1493 0.471241873923787 2282 672303 SGTC_637 1181-0519 7.26 µM 0.0719832946446472 0.449231930107614 no 1494 0.47130760115098 2256 6252091 YGR060W ERG25 SGTC_2787 5284540 71.43 µM 0.0681393454960715 0.450838464544041 no 1495 0.472837354973448 2205 736958 SGTC_2230 bromochlorosalicylanilide 954.5 nM 0.0680610751987845 0.450871185175824 no 1496 0.47286850798231 2283 77254 SGTC_312 4092-0653 6.84 µM 0.0680569108562258 0.450872926074434 no 1497 0.472870165471411 2249 1148278 SGTC_1092 toremifene 6.32 µM 0.0669207667106674 0.451347925015225 no 1498 0.473322390325756 2284 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_978 1416-0512 87.4 µM 0.0665805998661471 0.451490155492041 no 1499 0.473457795266739 2210 6814003 SGTC_224 benfluorex 43.875 µM 0.0658780165217799 0.451783939159934 no 1500 0.473737471414749 2287 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis. SGTC_202 3594-0513 34.79 µM 0.0638353814305451 0.45263821190768 no 1501 0.47455065269584 2301 708429 SGTC_704 1310-0270 142 µM 0.0629483663791739 0.453009248686005 no 1502 0.47490381019134 2232 5718033 SGTC_3067 9117431 49.47 µM 0.0624423890858571 0.453220916463563 no 1503 0.4751052695958 2229 17150885 SGTC_1413 3910-0535 34.4 µM 0.0607576680745366 0.453925788921315 no 1504 0.475776101992488 2271 2876951 SGTC_708 3448-5400 146 µM 0.060402821591578 0.454074272149817 no 1505 0.475917405728852 2304 3462195 SGTC_2885 9057732 51.95 µM 0.0594372959180827 0.454478322592759 no 1506 0.47630190385435 2233 6471414 SGTC_2555 cholic acid 100 µM 0.0592533353571491 0.454555311241651 no 1507 0.476375164379383 2222 6708657 Influences liver metabolism. SGTC_2575 plumbagin 510 nM 0.0589370849475238 0.454687668010862 no 1508 0.476501109930052 2281 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_1791 st048313 56.1 µM 0.0583932635382448 0.454915279297202 no 1509 0.476717690267954 2318 1204976 SGTC_300 r073-0011 5.04 µM 0.0577007017524638 0.455205165875048 no 1510 0.476993517355836 2312 2735780 SGTC_678 1218-2179 85.9 µM 0.057670200999487 0.455217933168402 no 1511 0.477005665167361 2318 6820081 YOR116C RPO31 SGTC_1684 st024538 14.6195 µM 0.05693140190254 0.455527200772905 no 1512 0.477299919885128 2284 6732859 SGTC_3198 9112019 49.47 µM 0.0561512743661768 0.455853798066817 no 1513 0.477610648650486 2283 45595555 SGTC_1304 1165-0502 251 µM 0.0553286004051256 0.45619823956602 no 1514 0.477938338615071 2276 767425 SGTC_883 0850-0245 24.6 µM 0.0550455071762957 0.45631677416716 no 1515 0.478051104621466 2251 6823229 YPR165W RHO1 SGTC_784 4579-0127 173 µM 0.055034042468526 0.456321574662658 no 1516 0.478055671455556 2307 1948547 SGTC_2368 9071271 200 µM 0.0539904339873179 0.456758580390278 no 1517 0.478471392849416 2260 27209959 SGTC_334 1502-1024 68.5 µM 0.053813704218663 0.456832590272219 no 1518 0.478541795476862 2229 3296216 SGTC_316 k060-0003 58.6 µM 0.0529391470802739 0.457198854299132 no 1519 0.478890196626343 2289 6152314 SGTC_2895 9054447 58.44 µM 0.0527122222466425 0.457293896242558 no 1520 0.478980600310584 2275 2697450 SGTC_1371 2421-0008 32.7 µM 0.0511632971492857 0.457942690775911 no 1521 0.479597699076444 2257 2827552 SGTC_3165 9101544 49.47 µM 0.0497093761164635 0.458551793198874 no 1522 0.480176992319024 2300 5002184 SGTC_1916 st067606 49.2 µM 0.0488265427910095 0.458921693002236 no 1523 0.480528764654409 2284 19590279 SGTC_1183 1254-0324 198 µM 0.0485471098003766 0.459038780521857 no 1524 0.480640110243131 2301 5799357 SGTC_3303 9125618 40.5795 µM 0.0483918367813737 0.459103844285347 no 1525 0.480701982494726 2265 22695467 SGTC_709 3807-1509 243 µM 0.0476173857613664 0.459428377375037 no 1526 0.481010587956269 2316 1886677 YPL242C IQG1 SGTC_2701 st077767 14.721 µM 0.0462615724898817 0.459996594827978 no 1527 0.481550883604599 2297 5721188 SGTC_2966 9084041 48.03 µM 0.0450557715642707 0.460502011224065 no 1528 0.482031427387087 2314 17741380 SGTC_247 mechlorethamine 29.705 µM 0.0442633065520312 0.460834210984028 no 1529 0.48234726006076 2306 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links. SGTC_3266 9136860 49.47 µM 0.0442030633005 0.460859465956372 no 1530 0.482371270140651 2325 4871271 YPR165W RHO1 SGTC_1903 st060211 78.3 µM 0.0437012329188031 0.461069847718505 no 1531 0.482571278215142 2322 688960 SGTC_2118 5526350 200 µM 0.0435984930550685 0.461112920576679 no 1532 0.4826122264625 2289 743594 SGTC_3232 9132874 49.47 µM 0.0435002683317689 0.461154100925263 no 1533 0.482651375316131 2319 3784940 SGTC_2348 9022543 33.42 µM 0.0427100135841372 0.461485427397544 no 1534 0.482966348584552 2284 3162678 YDL140C RPO21 SGTC_2862 9027634 71.43 µM 0.0410936508549976 0.462163195375233 no 1535 0.483610618106794 2307 5012562 SGTC_2092 5303694 80.6725 µM 0.0401107040099585 0.462575415313846 no 1536 0.484002434052262 2305 1963699 SGTC_1849 st056239 19.2 µM 0.0399953498304862 0.46262379421845 no 1537 0.484048416813046 2286 5393181 SGTC_2874 9043904 71.43 µM 0.0380879005166486 0.463423847531027 no 1538 0.484808799150173 2212 4463428 SGTC_1975 st070967 30.8 µM 0.037740380169005 0.463569626177193 no 1539 0.484947340098596 2343 261391 SGTC_890 0929-0006 47.2 µM 0.037684621393025 0.463593016454532 no 1540 0.484969568819006 2309 1378169 SGTC_2511 berberine 10.47 µM 0.0375241547882558 0.463660331374271 no 1541 0.485033540485332 2326 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_1119 parthenolide 318.541 nM 0.037218311900394 0.463788633780599 no 1542 0.485155468971035 2298 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs. SGTC_2668 2',4'-dihydroxychalcone 15.08 µM 0.0369719922200285 0.463891968684138 no 1543 0.485253668718635 2348 5357218 A potent inhibitor of glutathione S-transferases. SGTC_2858 9025781 8.96 µM 0.0359039139579932 0.464340072074652 no 1544 0.485679487497062 2335 4894980 YPL153C RAD53 SGTC_1749 st037932 54.2 µM 0.0353718701541227 0.464563303561125 no 1545 0.485891607517665 2284 594497 SGTC_1886 st057356 49.9 µM 0.0351169219097531 0.464670277048527 no 1546 0.485993254000797 2331 24207747 SGTC_672 1441-0018 53.7 µM 0.0326506519028097 0.465705227582898 no 1547 0.486976588481754 2343 251141 SGTC_634 1611-4317 11.2 µM 0.0309343002071269 0.466425618206279 no 1548 0.487660967697733 2355 2843522 SGTC_207 4185-0010 4.486 µM 0.0303514183928539 0.4666702916887 no 1549 0.487893394746278 2353 3761753 SGTC_1820 st053765 18.6 µM 0.0297016135308991 0.466943071979619 no 1550 0.488152512539613 2320 3690829 SGTC_2929 9013348 24.6 µM 0.0295191240931482 0.467019681655896 no 1551 0.488225283383174 2344 2995952 SGTC_1703 st026983 48.3 µM 0.0294089045284585 0.467065952789756 no 1552 0.488269235545438 2356 1104023 SGTC_1898 st060199 18.6 µM 0.0288066022512588 0.467318812379901 no 1553 0.488509417615724 2356 688866 SGTC_2995 9067767 71.4286 µM 0.0285203029204879 0.467439011694002 no 1554 0.48862358761293 2308 11673567 SGTC_254 nsc-64875 3.808 µM 0.0269606649848746 0.468093858691823 no 1555 0.489245553706337 2347 56993 SGTC_2107 5363541 170.161 µM 0.0268447992488628 0.468142510840814 no 1556 0.489291760722904 2363 244052 SGTC_3034 9090421 49.47 µM 0.0256041291573982 0.468663499245497 no 1557 0.489786546279856 2351 17173761 SGTC_3141 9094609 49.47 µM 0.0255231535571613 0.468697504800856 no 1558 0.489818840316665 2328 25236309 YDL196W YDL196W SGTC_2480 5767542 37.17 µM 0.0254947015837845 0.468709453209319 no 1559 0.489830187319427 2344 2867358 SGTC_2822 7994718 71.43 µM 0.0254686645944535 0.468720387469739 no 1560 0.489840571203566 2363 1018011 SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM 0.0250068536134849 0.46891432937854 no 1561 0.490024748463106 2377 16623 A steroid. SGTC_60 0986-0278 202 µM 0.0218209580364028 0.470252475017746 no 1562 0.4912953880355 2323 3110598 SGTC_743 1275-0778 158 µM 0.0215700608156444 0.470357871792984 no 1563 0.491395457990641 2361 2849257 YMR203W TOM40 SGTC_255 tunicamycin 200.472 nM 0.019804687221466 0.471099527315138 no 1564 0.49209958937787 2358 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_2551 apiole 73.87 µM 0.0197985065872817 0.471102124054439 no 1565 0.492102054610806 2363 10659 A possible DNA adduct former. SGTC_1330 1469-0054 61.8 µM 0.0183561230627119 0.471708162222354 no 1566 0.492677377631258 2380 7102664 SGTC_2949 9072542 2.23 µM 0.0176402764932678 0.472008959860033 no 1567 0.492962912836797 2350 16457352 SGTC_543 3844-1095 191 µM 0.0170424303489237 0.472260186141311 no 1568 0.493201383078016 2359 4230703 SGTC_193 1273-0060 1.558 µM 0.0162409142415557 0.472597015700429 no 1569 0.493521097458355 2377 2847393 YHR072W ERG7 SGTC_1366 1683-0113 21.9 µM 0.0145841540576122 0.473293315337942 no 1570 0.494181970570029 2375 708623 SGTC_2309 7664088 163.95 µM 0.0143539334568421 0.473390078467437 no 1571 0.4942738056878 2385 704922 SGTC_946 3434-1334 87.4 µM 0.0133236709260305 0.473823123278341 no 1572 0.494684781597695 2367 4047976 SGTC_2447 5741742 33.78 µM 0.0126536618161965 0.474104761302772 no 1573 0.494952054008755 2373 1776504 SGTC_2903 5923464 63.88 µM 0.0122428446831714 0.474277454507486 no 1574 0.495115933633676 2372 2876576 SGTC_2696 st077691 74.316 µM 0.0118520573292632 0.474441732377389 no 1575 0.495271823917352 2372 757133 SGTC_2584 androsterone 48.74 µM 0.0112283436409604 0.474703936025945 no 1576 0.495520633106162 2379 2754130 A steroid. SGTC_1800 st050079 29.0735 µM 0.0091733877381623 0.475567897990403 no 1577 0.496340399103341 2372 3645560 SGTC_3073 9114972 49.47 µM 0.00863406193913339 0.475794665108599 no 1578 0.496555550436506 2389 41905075 SGTC_3214 9129694 49.47 µM 0.0084270805064114 0.475881695449174 no 1579 0.496638121076716 2386 17158655 SGTC_766 1391-0721 126 µM 0.007571708850832 0.476241369270203 no 1580 0.496979354067203 2393 1020919 YIL115C NUP159 SGTC_1206 3978-0017 132 µM 0.00753155996208333 0.476258251888343 no 1581 0.496995370699737 2359 3873677 SGTC_2072 5231554 129 µM 0.0070947481867009 0.476441934101061 no 1582 0.497169628724213 2388 789545 SGTC_2328 6201408 200 µM 0.00697619967195905 0.47649178539328 no 1583 0.497216921568532 2391 2890418 SGTC_13 0199-0087 65 µM 0.00692784018588207 0.476512121332603 no 1584 0.497236213745978 2394 4589825 SGTC_1775 st081588 35.1725 µM 0.00686892655147574 0.476536895543182 no 1585 0.497259716326408 2389 1426443 YGL099W LSG1 SGTC_698 k064-0052 127 µM 0.00671043514478965 0.476603544393309 no 1586 0.497322943792147 2395 5088751 SGTC_478 N-arachidonylglycine 10 µM 0.00491958940959016 0.4773566763728 no 1587 0.498037375698993 2398 5283389 SGTC_753 1322-0200 289 µM 0.0049132023219619 0.477359362579617 no 1588 0.498039923747502 2395 5403907 SGTC_2466 5983409 37.09 µM 0.00409565271437389 0.477703206508134 no 1589 0.498366075534406 2381 2879657 SGTC_1789 tunicamycin 25 nM 0.00294254608775063 0.47818820671866 no 1590 0.498826095647624 2399 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_21 0849-0113 22.993 µM 0.000956475289208812 0.479023629563421 no 1591 0.499618421625156 2400 1560156 SGTC_2627 acetyl isogambogic acid 100 µM 0.000673297580886335 0.479142753316021 no 1592 0.499731393147987 2401 6857789 A caspase activator and apoptosis inducer. SGTC_3082 9117008 49.47 µM 0 0.4794259954111 no 1593 0.5 2406 41448529 SGTC_1262 0737-0114 49.6 µM -9.8352120616956e-05 0.479467370947468 no 1594 0.499960763180782 2406 765919 SGTC_3196 9111891 49.47 µM -0.00062389283039562 0.47968846324659 no 1595 0.499751102787663 2406 18891510 SGTC_806 3966-4455 5.86 µM -0.00183213500549245 0.480196788161986 no 1596 0.499269084291819 2413 714982 SGTC_1011 4112-3381 17.4 µM -0.00195885580749773 0.480250103311999 no 1597 0.499218530096944 2425 2877139 SGTC_3212 9128307 49.47 µM -0.00239443100626823 0.480433365234153 no 1598 0.499044761146874 2413 27243542 SGTC_1036 k216-0215 33.5 µM -0.00363906897904672 0.480957051197986 no 1599 0.498548224727229 2415 622330 SGTC_2259 7964009 200 µM -0.00439464309360235 0.481274977850195 no 1600 0.498246796705926 2429 313134 SGTC_153 4077-0274 519.67 µM -0.00447945542039496 0.481310665499057 no 1601 0.498212961815942 2416 3121976 SGTC_703 3875-0075 71.8 µM -0.00544279603558881 0.481716034018293 no 1602 0.4978286492585 2416 2850814 SGTC_1058 3448-5425 97.3 µM -0.00549729831281983 0.481738968850678 no 1603 0.49780690632103 2415 7279705 SGTC_2528 xanthyletin 44.79 µM -0.00574652219409273 0.481843844282317 no 1604 0.497707481948971 2415 65188 An natural product with antifungal activity of unknown mechanism. SGTC_535 2293-4129 48.2 µM -0.00649760989702308 0.482159915652499 no 1605 0.497407846930192 2419 396118 YIL048W NEO1 SGTC_1039 k821-0043 94 µM -0.0067812923796451 0.482279297330498 no 1606 0.497294676488479 2397 15992768 SGTC_3207 9114163 49.47 µM -0.00765224799276439 0.482645830169998 no 1607 0.496947224529109 2432 849233 SGTC_244 nsc-207895 1.295 µM -0.00801093697759189 0.48279678507462 no 1608 0.496804132716567 2400 42640 SGTC_2870 9038528 12.99 µM -0.00823438572420884 0.482890825129753 no 1609 0.496714992504903 2467 6463316 SGTC_2658 polymyxin b sulfate 77.05 µM -0.00845811649793983 0.482984984831738 no 1610 0.496625739948737 2421 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides.  YIL048W NEO1 SGTC_1452 4194-0072 190 µM -0.0101937986406015 0.483715498715575 no 1611 0.495933333154772 2423 1343545 SGTC_1618 st003135 44.5 µM -0.0103853235265368 0.483796111101224 no 1612 0.495856929824851 2418 1270615 SGTC_870 0573-2213 57.6 µM -0.010389075301446 0.483797690221312 no 1613 0.495855433163956 2425 3916321 SGTC_1015 4130-4525 82 µM -0.0110284200715068 0.484066793790392 no 1614 0.495600386132238 2430 1363237 SGTC_1938 st074717 56.4 µM -0.0112097225661361 0.484143106288059 no 1615 0.495528061372716 2419 17250979 SGTC_2033 5192550 145 µM -0.0113765977408364 0.484213346658925 no 1616 0.495461492055165 2431 182073 SGTC_2100 5377183 190 µM -0.0117577673543147 0.484373788744495 no 1617 0.49530943755403 2443 2844202 SGTC_990 3985-0011 41.3 µM -0.0117588751783795 0.484374255054 no 1618 0.495308995626722 2443 5399565 YGL099W LSG1 SGTC_2162 5663267 200 µM -0.0123984810147664 0.484643483914666 no 1619 0.495053848433105 2432 6456493 SGTC_2445 5742597 35.57 µM -0.012955495522686 0.484877953369772 no 1620 0.494831649653031 2439 1774255 SGTC_2975 9084847 53.72 µM -0.0140709106765915 0.485347491397468 no 1621 0.494386704037871 2472 27211724 SGTC_512 prima-1 270 µM -0.0145449047773497 0.485547027110697 no 1622 0.494197627106736 2446 322968 A re-activator of the apoptotic function of mutant p53. SGTC_683 panaxydol 45 µM -0.0159787528244972 0.486150651159317 no 1623 0.493625671160894 2454 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis. SGTC_731 3966-0296 387 µM -0.0165430990111276 0.486388239458222 no 1624 0.49340055937299 2437 660956 SGTC_14 0354-0009 295 µM -0.0167259402401673 0.486465216187612 no 1625 0.493327626367471 2441 1713507 SGTC_2671 danthron 100 µM -0.01673063905476 0.486467194409913 no 1626 0.493325752073927 2446 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin. SGTC_2188 6126565 140.678 µM -0.0172550456505988 0.486687974051533 no 1627 0.493116574316041 2437 874518 SGTC_1605 st000082 49.1 µM -0.0175694642861974 0.486820348934921 no 1628 0.49299115844272 2512 1114022 SGTC_1401 3807-4679 7.6 µM -0.0180630016481908 0.487028138367326 no 1629 0.492794296770275 2443 3291456 SGTC_51 1013-0126 23.419 µM -0.0194634219132211 0.487617763235598 no 1630 0.492235708298318 2430 1627850 SGTC_40 0327-0103 19.753 µM -0.0203895631681006 0.488007715354557 no 1631 0.491866304753231 2454 409036 SGTC_2699 st077704 54.6 µM -0.0217156649832605 0.488566090883615 no 1632 0.491337383934957 2468 645852 SGTC_2649 anisomycin 9.56 µM -0.0218747566588106 0.488633080403384 no 1633 0.491273930612132 2446 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_3231 9132313 49.47 µM -0.0228491536755638 0.489043381507633 no 1634 0.490885299640597 2463 4905967 SGTC_935 2996-0153 430 µM -0.0228652126041636 0.489050143732708 no 1635 0.490878894728345 2452 23738523 SGTC_154 3389-1638 511.116 µM -0.0233223080078805 0.489242622518415 no 1636 0.490696588667589 2483 5238686 SGTC_360 0957-0399 1.01 µM -0.023547563822399 0.489337476651271 no 1637 0.490606749272577 2462 6752301 YPR165W RHO1 SGTC_1744 st037937 38.9 µM -0.0236787543058547 0.489392720606895 no 1638 0.49055442643113 2481 1016152 SGTC_3309 9129340 25.759 µM -0.024561552461061 0.489764469747417 no 1639 0.490202343366045 2477 17158987 SGTC_1176 0848-0131 83.3 µM -0.0251710113855758 0.490021120067124 no 1640 0.489959279595317 2468 6769040 SGTC_3260 9137109 49.47 µM -0.0261970506760827 0.490453206555984 no 1641 0.489550084148053 2442 17478346 SGTC_1255 0566-0045 221 µM -0.0262390175064404 0.490470879903183 no 1642 0.489533347558281 2484 2788469 SGTC_3040 9091894 49.47 µM -0.0266406521257947 0.490640019852916 no 1643 0.48937317452388 2473 25236966 SGTC_3182 9108849 49.47 µM -0.0277953779989965 0.49112631757194 no 1644 0.488912676181226 2494 17133045 SGTC_2757 clomiphene 4.22 µM -0.0277975321360293 0.491127224771165 no 1645 0.488911817136818 2465 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined. SGTC_2325 6158266 200 µM -0.0281733839749151 0.491285512752198 no 1646 0.488761932653199 2493 3623240 SGTC_2200 6600604 21.907 µM -0.0291131130118843 0.491681280533812 no 1647 0.488387188780172 2457 2904777 SGTC_2996 9066192 71.4286 µM -0.0293463168625298 0.491779495841712 no 1648 0.488294193639314 2476 6472854 SGTC_652 0437-0092 114 µM -0.0298490359392417 0.491991220915187 no 1649 0.488093725573055 2458 3091274 SGTC_2237 6667747 47.222 µM -0.0309805195914089 0.492467764524547 no 1650 0.487642537664601 2502 729940 YDL015C TSC13 SGTC_1426 4048-4480 71.7 µM -0.0310190192933379 0.492483979522636 no 1651 0.487627185883913 2467 14224343 SGTC_211 3455-0679 143.504 µM -0.0311087535237346 0.49252177311988 no 1652 0.487591404373539 2486 748649 SGTC_2416 tofa 880 nM -0.0312563809646978 0.492583949895833 no 1653 0.487532538171952 2498 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_1057 3448-5381 134 µM -0.0316140806598349 0.492734604296714 no 1654 0.487389907130172 2492 5497911 SGTC_554 4483-2211 187 µM -0.0316647683339135 0.492755952795017 no 1655 0.487369695792733 2509 747107 SGTC_451 chloral hydrate 100 µM -0.0316912660930399 0.492767113058234 no 1656 0.487359130018973 2503 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1 SGTC_1135 dihydrocapsaicin 536.708 nM -0.0320022070511282 0.492898074852693 no 1657 0.487235145414026 2452 107982 A Capsaicinoid. SGTC_206 4546-0025 72.014 µM -0.0334709321875132 0.493516681112948 no 1658 0.48664952279643 2474 6620745 YIL048W NEO1 SGTC_1053 3366-3204 134 µM -0.0347687427075899 0.49406331357717 no 1659 0.486132072630242 2488 3632071 YPR165W RHO1 SGTC_2526 patulin 37.61 µM -0.0356017250341739 0.494414168252438 no 1660 0.485799966408439 2513 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.  SGTC_1889 st059080 5.18 µM -0.0371568161295636 0.49506918867867 no 1661 0.485179985276237 2474 176925 Isolated from Daphnopsis sellowiana. SGTC_2358 9037157 4 µM -0.0386523903824174 0.495699152558251 no 1662 0.484583765994396 2516 2388925 SGTC_1027 k015-0025 8.67 µM -0.0391925431219448 0.495926677724907 no 1663 0.484368439398549 2481 3598955 SGTC_1442 4112-3290 3 µM -0.0398771708761216 0.496215061094654 no 1664 0.484095525812398 2463 704353 SGTC_3162 9099653 49.47 µM -0.0404103536669036 0.496439653206466 no 1665 0.483882987980161 2482 25237511 SGTC_435 c-PAF 6.7 µM -0.0409686517804457 0.496674825831551 no 1666 0.483660443562996 2480 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase SGTC_111 0083-0039 52.457 µM -0.0410423742269536 0.496705880119679 no 1667 0.483631057278279 2462 759313 SGTC_2765 myclobutanil 7.74 µM -0.0426332163538323 0.497375999024105 no 1668 0.482996958365875 2532 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11 SGTC_1491 4138-0063 26.5 µM -0.0434457303123112 0.497718261582996 no 1669 0.482673112287901 2485 23883227 SGTC_517 1365-0151 113 µM -0.0441973334524378 0.498034867631263 no 1670 0.482373553787481 2607 768657 SGTC_2165 5727197 32.143 µM -0.0444443378246485 0.498138916276662 no 1671 0.482275110036036 2739 1361712 SGTC_16 erodoxin 22.806 µM -0.0445707634614703 0.498192172129366 no 1672 0.482224723434902 2502 3967339 Erodoxin inhibits Ero1. YML130C ERO1 SGTC_572 0960-0087 17.7 µM -0.0455474759698081 0.49860360597301 no 1673 0.48183546689413 2477 6796365 SGTC_1260 0700-1617 7.75 µM -0.0462990589392516 0.498920206484703 no 1674 0.481535944682171 2517 2853078 SGTC_1269 0831-0796 3.05 µM -0.0468749747645854 0.49916280857415 no 1675 0.481306436704181 2516 927758 SGTC_625 k213-0058 121 µM -0.0471919349767153 0.499296326851863 no 1676 0.481180127659194 2533 3655420 SGTC_1376 2910-0861 41.3 µM -0.0486668810570488 0.49991764304712 no 1677 0.480592384837186 2500 1112859 SGTC_3041 9091929 49.47 µM -0.0487175294401046 0.499938978524406 no 1678 0.480572202994817 2535 25236887 SGTC_1523 st012844 44.7 µM -0.0490072477333363 0.499938978524406 no 1679 0.4804567600129 2594 4274103 SGTC_1936 st074407 74.3 µM -0.0494669299190334 0.499745338815978 no 1680 0.480273595511723 2485 809813 SGTC_503 tyrphostin 8 294 µM -0.0503705623684397 0.499364686640629 no 1681 0.479913547212324 2486 92970 A tyrosine kinase inhibitor. YOR207C RET1 SGTC_1516 st013856 110 µM -0.0505775216485758 0.499277505798451 no 1682 0.479831087510591 2629 5281404 A mutagen and neurotoxin. SGTC_17 0960-0276 49.807 µM -0.0505990756909353 0.499268426238606 no 1683 0.479822499687689 2500 6821114 SGTC_1351 1496-0003 46.5 µM -0.0513163879095991 0.49896626139049 no 1684 0.479536704822917 2518 3891978 SGTC_902 1120-0002 2.07 µM -0.0521407226830667 0.498619014470422 no 1685 0.479208282535247 2518 3280475 SGTC_1292 0kpi-0043 232 µM -0.0523707572439256 0.498522113732133 no 1686 0.479116637234813 2524 3333905 SGTC_903 1134-0042 114 µM -0.0538896089708874 0.497882308617289 no 1687 0.478511557738461 2505 701009 SGTC_2451 5856223 45.7 µM -0.054039368316726 0.497819223862954 no 1688 0.478451899334439 2525 2179896 SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM -0.0541120785127181 0.497788595377662 no 1689 0.47842293454321 2491 17037758 SGTC_805 3852-0218 479 µM -0.0546250704566653 0.497572502733282 no 1690 0.478218582619011 2515 6615355 SGTC_3331 9141060 1.957 µM -0.0559590940159304 0.497010562355341 no 1691 0.477687197158286 2519 4906567 YPR165W RHO1 SGTC_2743 auranofin 4.32 µM -0.0565079011746703 0.496779386010984 no 1692 0.477468600678571 2527 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold. SGTC_1559 coumarin 343 70.1 µM -0.0569498092492536 0.496593239999157 no 1693 0.477292588311227 2560 108770 A hepatotoxic, DNA x-linker. SGTC_770 0389-1121 67.2 µM -0.0577080090550736 0.496273863403568 no 1694 0.476990607013324 2664 6753108 SGTC_840 0245-0196 390 µM -0.0582930415327283 0.496027431724145 no 1695 0.476757605072053 2613 3827528 SGTC_2432 5630864 12.22 µM -0.0587754677733307 0.495824221734187 no 1696 0.476565474276387 2596 5714970 SGTC_421 streptovitacin 30 mM -0.0592512173802078 0.495623825170116 no 1697 0.476376007847995 2698 91467 include heat shock SGTC_261 5-fluorouridine 15.376 µM -0.0606741978613957 0.495024440191111 no 1698 0.475809340467593 2543 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_2279 7948423 32.93 µM -0.0631381438819684 0.493986609142655 no 1699 0.474828250225743 2502 1247112 SGTC_2255 7941087 197.44 µM -0.0633814780354524 0.49388411721361 no 1700 0.474731367989804 2513 935561 SGTC_2877 9040724 71.43 µM -0.0634696543808733 0.493846977587108 no 1701 0.474696261401993 2526 6463895 SGTC_2185 6113692 200 µM -0.0647200665409959 0.493320313426257 no 1702 0.474198442763783 2582 874150 SGTC_141 0443-0274 32.331 µM -0.0656209444167037 0.492940877630025 no 1703 0.473839806909189 2526 1627241 SGTC_369 0957-0393 4.5 µM -0.0659283250128436 0.492811415131951 no 1704 0.473717444768004 2545 6997992 SGTC_3074 9116018 49.47 µM -0.0667316080909773 0.492473092135157 no 1705 0.473397685384848 2516 17027303 SGTC_327 1273-0057 3.96 µM -0.0682525359421 0.491832529910543 no 1706 0.472792303401076 2531 3108138 SGTC_2728 chlorpromazine 9.18 µM -0.0686281630720307 0.491674331930136 no 1707 0.472642800410592 2516 2726 A thorazine and dopamine antagonist. SGTC_832 4083-0019 164 µM -0.0695415152453102 0.491289672817698 no 1708 0.472279294116206 2617 1990758 SGTC_1139 k015-0024 46.9 µM -0.0700021021687942 0.491095699258844 no 1709 0.472095993227691 2510 2766652 SGTC_2145 5634607 200 µM -0.0702924357120722 0.490973428020261 no 1710 0.471980451521779 2518 308662 SGTC_1129 3453-1384 223 µM -0.070848140757031 0.490739400447094 no 1711 0.471759308637011 2733 1084452 SGTC_818 4072-2707 53.5 µM -0.0710736233558431 0.490644442441658 no 1712 0.471669580290826 2549 882871 SGTC_3328 9140624 29.0385 µM -0.0715992862007249 0.49042307090701 no 1713 0.471460404074223 2557 4904392 SGTC_1033 k072-0102 21.3 µM -0.0719260617509014 0.49028545793625 no 1714 0.471330374740893 2520 5965931 SGTC_3172 9105863 49.47 µM -0.072210373328282 0.490165728496424 no 1715 0.471217245002251 2526 2348785 SGTC_1632 st005650 90 µM -0.072286083643304 0.490133845478014 no 1716 0.471187119683391 2611 2759605 SGTC_2880 9042983 58.44 µM -0.0727516574595138 0.489937785099069 no 1717 0.471001870357975 2625 6464714 SGTC_1747 st037496 66.6 µM -0.0731815256545282 0.489756763070488 no 1718 0.470830833678069 2560 723305 SGTC_835 0312-0010 67.2 µM -0.0733206916304802 0.489698159261232 no 1719 0.47077546323704 2528 1626196 SGTC_894 0960-0238 55.9 µM -0.0734202960569552 0.489656215245987 no 1720 0.470735833631332 2504 6741907 YDL195W SEC31 SGTC_2674 ligustilide 100 µM -0.0746654956757337 0.489131864098883 no 1721 0.470240430736855 2597 5319022 A signalling regulator. SGTC_922 1866-0035 480 µM -0.0751987395290667 0.488907321836818 no 1722 0.470028293613391 2546 3156169 SGTC_2626 ethyl orsellinate 100 µM -0.0756330505995766 0.488724441516651 no 1723 0.469855520593369 2555 75653 A natural product. SGTC_1475 4092-1048 11.7 µM -0.0762013601482323 0.488485140514348 no 1724 0.469629450297929 2577 2881759 SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM -0.0770985117783349 0.488107380769464 no 1725 0.469272588453583 2520 6708784 An antioxidant flavonoid SGTC_2662 daunorubicin 22.37 µM -0.0771790013140551 0.488073489906356 no 1726 0.469240573168181 2518 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_2682 pyrogallin 40.03 µM -0.0782157187769626 0.487636978219571 no 1727 0.468828229273383 2558 822798 An ATP competetive kinase inhibitor. SGTC_1956 st077085 54 µM -0.0785836330382566 0.487482070814949 no 1728 0.468681903109095 2583 24208685 SGTC_1622 st003707 19.4 µM -0.0787155445136543 0.487426530984974 no 1729 0.468629440555835 2649 10140899 SGTC_62 0180-0423 3.232 µM -0.079139121541761 0.487248190337498 no 1730 0.468460983293855 2578 30102 YGL099W LSG1 SGTC_2156 5649887 115 µM -0.079296338900045 0.487181997013589 no 1731 0.468398459134175 2642 54680440 YKL052C | YBR257W ASK1 | POP4 SGTC_3142 9086498 49.47 µM -0.079315262757062 0.487174029513861 no 1732 0.468390933311247 2557 25236367 SGTC_2420 aureobasidin a 50 nM -0.0803438059198658 0.486740990412574 no 1733 0.467981909357607 2798 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1 SGTC_236 1509-0011 5.31 µM -0.0805239834213003 0.486665133350013 no 1734 0.467910261077936 2596 3107280 SGTC_496 calpeptin 138 µM -0.0810572725021523 0.486440614575348 no 1735 0.467698202714724 2624 73364 A calpain inhibitor. SGTC_1294 1000-1494 117 µM -0.0838463421807368 0.485266466596323 no 1736 0.466589300992241 2557 712797 YDL207W GLE1 SGTC_1145 3546-0597 10.2 µM -0.084664462936786 0.484922076302589 no 1737 0.466264074479477 2602 875334 SGTC_2292 7671323 168.05 µM -0.0862376951684929 0.484259851483281 no 1738 0.465638732948967 2643 937504 SGTC_3249 9135183 49.47 µM -0.087037951613738 0.483923013956913 no 1739 0.465320672766807 2713 4902779 SGTC_1887 st057648 70.8 µM -0.0872138147456834 0.483848992586835 no 1740 0.465250779309867 2684 688672 SGTC_1868 st057644 42.7 µM -0.0873092062285867 0.483808842230934 no 1741 0.465212868227596 2550 688665 SGTC_1171 0368-0077 21.4 µM -0.0888414871516855 0.483163926672429 no 1742 0.464603943025055 2571 3239779 SGTC_305 1682-2595 20.8 µM -0.08898231290823 0.48310465727033 no 1743 0.464547983304284 2613 226033 SGTC_769 0302-0231 76 µM -0.0890248808649077 0.483086741747896 no 1744 0.464531068276815 2610 571869 YER009W NTF2 SGTC_1079 idarubicin 2.36 µM -0.089370082629927 0.482941458379362 no 1745 0.464393899455617 2563 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_1382 3002-2117 298 µM -0.0896102332111982 0.482840388720538 no 1746 0.464298476099761 2584 1497314 SGTC_2888 9058547 12.99 µM -0.0896926021517848 0.482805723221224 no 1747 0.464265747437707 2587 16476514 SGTC_1218 1348-1416 30.7 µM -0.0905679645690655 0.482437329391219 no 1748 0.463917943928039 2554 6787668 SGTC_2608 thymoquinone 42.66 µM -0.0910814627254781 0.482221232083219 no 1749 0.463713931006908 2537 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC). SGTC_1445 4239-0156 97.7 µM -0.0911964701494932 0.482172833801856 no 1750 0.463668239840061 2749 4008346 SGTC_2409 alverine citrate 63.97 µM -0.0913696720412216 0.482099946186839 no 1751 0.463599429564745 2867 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_909 3448-9333 149 µM -0.0921080336924435 0.481789232189471 no 1752 0.46330610281263 2567 3344074 SGTC_1230 0170-0365 3.77 µM -0.0940833531352914 0.480958042129125 no 1753 0.46252147199666 2654 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1 SGTC_1638 st008370 60.6 µM -0.0944202020772525 0.48081630841059 no 1754 0.462387684278662 2554 24207134 SGTC_373 0844-0104 25.9 µM -0.0953141559835097 0.480440177098129 no 1755 0.462032649498198 2621 5375804 SGTC_821 1114-0266 29.2 µM -0.0966974015192014 0.479858210659264 no 1756 0.461483351724479 2645 3123235 SGTC_2854 9024559 71.43 µM -0.097868621630003 0.479365482203761 no 1757 0.46101830832559 2643 3163529 SGTC_1184 1269-1718 139 µM -0.0987269448670815 0.479004408413995 no 1758 0.460677537232357 2686 5403821 SGTC_2429 5902844 64.44 µM -0.0989140757681658 0.478925689691361 no 1759 0.460603246434231 2698 1927790 YGL093W | YPR107C SPC105 | YTH1 SGTC_1134 3477-0009 42.5 µM -0.0989757898439944 0.478899729149908 no 1760 0.460578746303463 2755 3973534 SGTC_1279 0874-0590 65.2 µM -0.0991057122226463 0.478845076508904 no 1761 0.460527168360674 2641 3523074 SGTC_2604 4'-hydroxychalcone 11.32 µM -0.0993378479197372 0.478747428203002 no 1762 0.460435014361133 2694 5282362 SGTC_2684 capsaicin 100 µM -0.0999182268660647 0.478503296331357 no 1763 0.460204622909484 2676 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_1961 st076550 68.7 µM -0.100181536453883 0.478392539863556 no 1764 0.460100102019622 2686 1579337 SGTC_1763 st044482 94.5 µM -0.101584114639017 0.477802598765358 no 1765 0.459543394447868 2705 88505 SGTC_2263 7948595 193.29 µM -0.101930580512013 0.477656878531691 no 1766 0.459405888316745 2587 2971371 SGTC_2253 7938677 135.83 µM -0.102043412725345 0.477609423025417 no 1767 0.45936110826933 2789 2301972 SGTC_83 0170-0301 39.027 µM -0.102542599268451 0.477399476605287 no 1768 0.459163000853704 2576 3089716 SGTC_1084 voriconazole 435 nM -0.102644096078714 0.477356790138329 no 1769 0.459122722018865 2605 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_436 n,n-dimethylsphingosine 3.3 µM -0.103567015590891 0.476968650284342 no 1770 0.458756482302354 2889 5282309 SGTC_2833 9001315 45.46 µM -0.10499515337997 0.476368080764426 no 1771 0.458189827253217 2655 2989378 SGTC_1941 st076221 61.8 µM -0.105379887231818 0.476206299177134 no 1772 0.458037187429194 2756 2828568 SGTC_996 3970-0799 1.8 µM -0.10589311127703 0.475990493238968 no 1773 0.457833579871133 2630 6615648 YGL040C HEM2 SGTC_595 3909-8003 73.7 µM -0.106166144236636 0.475875688284435 no 1774 0.457725266041662 2672 699517 SGTC_2973 9094665 17.96 µM -0.107160521132756 0.475457589483568 no 1775 0.457330817300276 2840 25237061 YIL048W NEO1 SGTC_2150 5556613 200 µM -0.107884399531971 0.475153242291337 no 1776 0.457043696128814 2625 743190 SGTC_1528 arabinosylhypoxanthine 74.6 µM -0.107892355435241 0.475149897394245 no 1777 0.457040540601183 2796 804 An inhibitor of viral and cellular DNA polymerases. SGTC_907 3448-6986 75.5 µM -0.108282275713254 0.474985965525475 no 1778 0.456885890936714 2664 590582 SGTC_2056 5235370 200 µM -0.108284472048003 0.474985042145457 no 1779 0.456885019847804 2640 5511916 SGTC_389 tpck 16.7 µM -0.108313752773074 0.474972731996348 no 1780 0.456873406831433 2646 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.  SGTC_1443 4112-3303 14 µM -0.108440384413275 0.474919494028043 no 1781 0.456823183932701 2599 704433 SGTC_1181 1222-0449 220 µM -0.109852754121931 0.474325741765793 no 1782 0.45626307621684 2716 658318 SGTC_3289 9119912 71.43 µM -0.110048287736197 0.474243545000737 no 1783 0.456185539684423 2677 17014829 SGTC_905 2-aminofluorene 215 µM -0.110473113099591 0.474064964295287 no 1784 0.456017085986348 2606 1539 An established DNA mutagen. YPR165W RHO1 SGTC_829 1635-0120 117 µM -0.111421938600898 0.473666132386258 no 1785 0.455640881945395 2732 285054 SGTC_1050 3232-1156 69.3 µM -0.112185761763995 0.473345084024184 no 1786 0.455338059182691 2647 700529 SGTC_1511 0906-3109 28.5 µM -0.112697523766581 0.473129991091353 no 1787 0.455135182245846 2590 2882180 SGTC_649 1123-0311 367 µM -0.113186914677004 0.47292430802794 no 1788 0.454941184786575 2674 693629 YIL048W NEO1 SGTC_82 0054-0107 293.755 µM -0.113211537546852 0.472913959625326 no 1789 0.454931424418482 2697 3104697 SGTC_1721 st082152 9.2685 µM -0.113665126535724 0.472723330311796 no 1790 0.454751629149704 2603 5296051 SGTC_3200 9114385 49.47 µM -0.114148425709941 0.472520221608977 no 1791 0.454560067449581 2714 17018030 YLR208W SEC13 SGTC_2943 9068529 45.32 µM -0.114180751584462 0.472506636765751 no 1792 0.454547255059621 2602 3270634 SGTC_727 3032-0951 202 µM -0.116252022208931 0.471636259413566 no 1793 0.453726404222389 2687 3652836 SGTC_712 r015-0009 80.6 µM -0.11675980229225 0.471422903519503 no 1794 0.453525199463717 2705 6813872 YLR060W FRS1 SGTC_1270 0831-1170 17.3 µM -0.11707343181896 0.471291128698409 no 1795 0.453400931634029 2618 6764716 SGTC_1298 1079-1278 263 µM -0.117205635016257 0.471235583043071 no 1796 0.453348550800956 2642 2840950 SGTC_2446 5162541 200 µM -0.117870960977709 0.470956052430534 no 1797 0.453084951299584 2610 1549321 SGTC_84 0443-0269 128.823 µM -0.118109698704179 0.470855752441364 no 1798 0.452990369394833 2609 6150058 SGTC_1601 4'-hydroxyflavanone 55.5 µM -0.119779031390535 0.470154473947993 no 1799 0.452329096432718 2806 165506 SGTC_1554 st069299 38.7 µM -0.120025628164443 0.470050887643879 no 1800 0.452231423186226 2689 24207999 SGTC_65 0798-0905 34.986 µM -0.120609056816586 0.469805818644415 no 1801 0.452000347456769 2922 3602145 SGTC_959 1222-0044 107 µM -0.121918476538884 0.469255839131703 no 1802 0.451481791312539 2644 6083612 SGTC_355 1311-2252 105 µM -0.125509090988235 0.467748021426352 no 1803 0.450060264191146 2666 5338538 SGTC_2772 vinpocetine 57.06 µM -0.125773687316834 0.46763692671846 no 1804 0.449955535411128 2744 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor. SGTC_827 3253-0474 693 µM -0.127615293224826 0.466863771359707 no 1805 0.449226713925124 2658 5402065 SGTC_1736 st036774 51 µM -0.127706100745834 0.46682565114671 no 1806 0.449190780966123 2913 1272247 SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM -0.128094364013475 0.466662665016758 no 1807 0.449037148086128 2738 7104 SGTC_1208 2323-2347 50.3 µM -0.129255690811133 0.466175193810311 no 1808 0.448577665427354 2695 5412760 SGTC_2057 5236571 38.335 µM -0.130244398828279 0.465760219933124 no 1809 0.448186534268909 2708 54684039 YBR257W POP4 SGTC_3103 9120822 49.47 µM -0.130399843493975 0.465694981118808 no 1810 0.448125045203618 2838 17141819 SGTC_281 1672-3440 14.9 µM -0.130900793969035 0.465484742713889 no 1811 0.447926893295819 2730 6833000 SGTC_2845 9003024 42.97 µM -0.131160793956421 0.465375629967371 no 1812 0.447824054927913 2855 2990173 SGTC_108 0509-0257 621.132 µM -0.131827634551025 0.465095792608542 no 1813 0.447560314046025 2730 536624 SGTC_2721 ifenprodil 61.44 µM -0.132471489758963 0.464825617365283 no 1814 0.44730568606936 2752 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor. SGTC_9 0092-0002 10.449 µM -0.133303106784288 0.464476677313842 no 1815 0.44697683533587 2664 759368 SGTC_3137 9097352 49.47 µM -0.134460106201905 0.463991254836395 no 1816 0.446519377602864 2904 44120435 SGTC_432 NS 1619 61.3 µM -0.134735384900061 0.463875768722586 no 1817 0.446410547582431 2808 4552 A K+/calcium channel activator. SGTC_2106 5357045 167.29 µM -0.136655070577211 0.46307049901709 no 1818 0.445651722372856 2763 668842 SGTC_1114 scopoletin 1.73284 µM -0.137045619545116 0.462906689959861 no 1819 0.445497368041654 2638 5280460 A coumarin with genotoxic properties. SGTC_2648 atorvastatin 78.68 µM -0.137068419634947 0.462897127047807 no 1820 0.445488357153604 2692 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11 SGTC_2720 fluspirilene 36.88 µM -0.137295543707536 0.462801866860884 no 1821 0.445398596344117 2733 3396 An atypical antipsychotic. SGTC_715 0868-0130 184 µM -0.137728215656359 0.462620401864342 no 1822 0.445227609517277 2746 2876258 SGTC_2693 st077581 40.7 µM -0.137836307765335 0.462575068651953 no 1823 0.44518489438621 2660 25238761 SGTC_1575 cyproterone acetate 48 µM -0.138579953440496 0.462263201115196 no 1824 0.444891042639036 2700 9880 An androgen receptor antagonist and liver toxin. SGTC_798 1287-0182 476 µM -0.139102223838885 0.46204418702795 no 1825 0.444684685471583 2653 1649755 SGTC_1678 st019265 80.2 µM -0.140546670051939 0.46143851865076 no 1826 0.444114040513192 2755 5367020 SGTC_405 ebelactone b 50 µM -0.140874969854402 0.461300872219868 no 1827 0.443984358044015 2666 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).  SGTC_3345 9148410 3.559 µM -0.140897677490303 0.461291351748643 no 1828 0.443975388469508 2726 4903596 SGTC_2842 9000675 19.48 µM -0.142281320809254 0.460711283382352 no 1829 0.443428900124417 2731 2989072 SGTC_1803 st050068 52.4 µM -0.142327089225232 0.460692097192479 no 1830 0.443410825111745 2655 3984059 YIL048W | YNL267W NEO1 | PIK1 SGTC_721 1187-1332 279 µM -0.142706831035031 0.460532912379381 no 1831 0.443260860777693 2630 25730 SGTC_1556 plumbagin 1.48 µM -0.142828255201584 0.460482013646481 no 1832 0.44321291071519 2651 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_1871 st057448 67.3 µM -0.142870598727398 0.460464264186981 no 1833 0.44319618957124 2811 691747 SGTC_2564 betulinic acid 100 µM -0.14446188631351 0.459797289419012 no 1834 0.442567875510028 2849 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14 SGTC_2733 amorolfine 100 µM -0.145006238859163 0.459569154514088 no 1835 0.442352972979471 2678 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_324 1315-0088 19.6 µM -0.145525839579324 0.459351405368086 no 1836 0.442147857934749 2737 6787421 SGTC_563 tetrahydrosecaminediol 614 µM -0.145648123453316 0.459300161618117 no 1837 0.442099588001855 2783 334274 A psychoactive constituent of the cannabis plant. SGTC_1795 st049545 62.3 µM -0.145653409104872 0.459297946651137 no 1838 0.442097501580581 2648 5291882 SGTC_2958 9077254 16.72 µM -0.146081658158145 0.459118491898746 no 1839 0.441928462874773 2829 16457351 SGTC_2834 9001755 58.44 µM -0.14617125290135 0.459080948904503 no 1840 0.441893099324208 2790 2989575 SGTC_620 0109-0052 432 µM -0.147209424209571 0.458645949417651 no 1841 0.441483361098431 2709 493037 SGTC_816 0325-0417 81.3 µM -0.147317233036625 0.458600779755434 no 1842 0.441440815442307 2729 68101 SGTC_53 0973-0023 39.979 µM -0.148589716419916 0.458067676160938 no 1843 0.440938694016015 2659 674768 SGTC_1373 2887-0003 58.5 µM -0.148888572660614 0.457942482020201 no 1844 0.440820779201364 2765 776948 SGTC_2027 5150920 200 µM -0.15013536629178 0.457420231717069 no 1845 0.440328908967842 2753 786715 SGTC_2944 9067346 25.62 µM -0.150728390735431 0.457171854528579 no 1846 0.440094988261555 2816 6473075 SGTC_1297 1068-0111 14.1 µM -0.151145315026509 0.456997243601798 no 1847 0.439930543430228 2663 767057 SGTC_1207 2099-0101 141 µM -0.152010665582386 0.456634855028116 no 1848 0.439589261747796 2770 5837381 SGTC_2126 5251174 33.877 µM -0.152183649237436 0.456562417834644 no 1849 0.439521044884036 2769 790722 SGTC_2792 7535235 81.82 µM -0.153222784269445 0.456127308773923 no 1850 0.439111295287592 2757 1281891 SGTC_1137 ixabepilone 100 µM -0.155950649571502 0.45498534225209 no 1851 0.438035960546349 2672 154225 A novel microtubule stabilizer. SGTC_2440 5628896 157.78 µM -0.156564972998728 0.454728218945845 no 1852 0.437793854765025 2704 5522048 SGTC_2386 9075165 157.42 µM -0.156566092285445 0.454727750488882 no 1853 0.43779341367368 2670 16452277 SGTC_1844 rapamycin 4 nM -0.15695527783963 0.45456486782225 no 1854 0.437640047134478 2670 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2 SGTC_822 1487-0950 154 µM -0.158145095143719 0.454066950752068 no 1855 0.437171233450605 2707 1958375 SGTC_979 1426-2828 121 µM -0.159128302136741 0.453655550801209 no 1856 0.436783895218075 2806 747872 SGTC_2479 5617353 43.85 µM -0.159152904059585 0.453645257338348 no 1857 0.436774203970123 2823 2731746 SGTC_1234 0326-0494 15.5 µM -0.159497593280367 0.453501042389046 no 1858 0.436638427165342 2824 1547813 SGTC_2630 antimycin a 100 µM -0.159779724556638 0.453383005698012 no 1859 0.436527298164734 2639 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain. SGTC_1822 st052468 42 µM -0.160585682852486 0.45304583556488 no 1860 0.436209865984426 2727 2873678 SGTC_541 4513-1321 94 µM -0.161064290294511 0.452845627640859 no 1861 0.436021382602347 2714 747515 SGTC_2321 7390090 138.78 µM -0.16130439040621 0.452745195049761 no 1862 0.435926832749655 2782 649046 SGTC_2937 9044753 11.33 µM -0.161494360274781 0.452665733812784 no 1863 0.435852026453153 2685 6465530 YGL099W LSG1 SGTC_2930 9013230 14.89 µM -0.161818415673615 0.452530191204705 no 1864 0.435724425281401 2800 2995857 SGTC_3268 9137683 49.47 µM -0.162111946588347 0.452407420842606 no 1865 0.435608849310743 2669 1953228 SGTC_3023 9089636 49.47 µM -0.162807042930054 0.452116712461278 no 1866 0.435335181401678 2675 17249241 SGTC_987 1497-1013 404 µM -0.163201790673335 0.451951629531811 no 1867 0.435179778178823 2688 1676435 SGTC_156 3474-0145 5.642 µM -0.164498745673436 0.451409303481719 no 1868 0.434669267052795 2642 2265471 SGTC_1908 st060353 56.5 µM -0.165314746417356 0.451068136463907 no 1869 0.434348126274393 2862 4227716 SGTC_2893 9048488 25.97 µM -0.165680838844084 0.450915086248812 no 1870 0.434204063010563 2704 6467338 SGTC_1492 4158-0558 28.5 µM -0.166755011978811 0.450466054892352 no 1871 0.433781409090508 2809 3967268 SGTC_1740 st038286 13.222 µM -0.167470640030139 0.450166939539588 no 1872 0.433499873562751 2895 716786 SGTC_1877 wortmannin 25 µM -0.167745767482621 0.450051950390441 no 1873 0.433391644529207 2802 312145 A covalent inhibitor of PI 3-kinase. SGTC_853 0419-0306 21 µM -0.169021883734563 0.449518654300248 no 1874 0.432889714156244 2697 762713 SGTC_521 r062-0005 13.8 µM -0.170520451796101 0.448892510819497 no 1875 0.432300425844965 2675 2832033 SGTC_2753 fluvastatin 17.09 µM -0.170797011562796 0.44877697030951 no 1876 0.432191689487405 2786 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5 SGTC_985 1493-0307 8.71 µM -0.171558205092251 0.448458983070633 no 1877 0.43189243384737 2793 3278274 SGTC_772 k072-0172 35.3 µM -0.171627592392089 0.448429998293549 no 1878 0.431865156863731 2734 5861980 SGTC_2744 captopril 92.04 µM -0.172743768975119 0.447963781893498 no 1879 0.431426419128257 2774 44093 angiotensin-converting enzyme (ACE) inhibitor  SGTC_2623 humulene 100 µM -0.172858131934949 0.447916017615378 no 1880 0.431381471021964 2779 6187145 An anti-inflammatory. SGTC_1788 fluconazole 20 µM -0.175102153955483 0.44697894392836 no 1881 0.430499682904137 2799 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11 SGTC_1348 1493-0373 93.8 µM -0.175542213542599 0.446795215453616 no 1882 0.43032680204739 2789 3010129 SGTC_2138 5575593 77.673 µM -0.176049494022106 0.446583435878195 no 1883 0.430127529508495 2709 762213 SGTC_2483 5729050 27.16 µM -0.177938752492513 0.44579484229635 no 1884 0.429385538184576 2810 2865180 SGTC_1663 st014140 55.4 µM -0.179174554522327 0.445279123133236 no 1885 0.428900321472059 2727 4207120 SGTC_2024 5144227 134 µM -0.179400762713695 0.445184732981277 no 1886 0.428811516271918 2880 3475211 SGTC_3318 9139014 38.6185 µM -0.180232458693785 0.444837717001204 no 1887 0.42848503865307 2720 16643984 SGTC_96 0929-0093 37.281 µM -0.180704105905052 0.444640946166887 no 1888 0.428299917900318 2709 6991579 SGTC_406 estrone 100 µM -0.180829649681723 0.444588571701892 no 1889 0.428250644832012 2900 5870 A steroid. SGTC_26 0302-0163 425.158 µM -0.181223658312242 0.444424205116004 no 1890 0.428096012700693 2716 3100915 SGTC_2315 7733312 200 µM -0.181596934812927 0.444268496063226 no 1891 0.427949527259345 2756 726316 SGTC_1073 triclabendazole 3.09 µM -0.182547141751009 0.443872164356919 no 1892 0.427576681020151 2795 50248 An antihelmetic and likely tubulin inhibitor. SGTC_159 3970-0959 50 µM -0.182670195267122 0.443820842781241 no 1893 0.42752840148083 2829 6615653 SGTC_1926 methyl fluorone black 53.6 µM -0.182845649126323 0.443747668374935 no 1894 0.427459564760086 2725 72721 Reacts with homocysteine. SGTC_513 4245-1575 41.7 µM -0.183295037168097 0.443560256324853 no 1895 0.427283264100005 2846 719745 SGTC_3066 9117245 49.47 µM -0.183502379030947 0.443473791068392 no 1896 0.427201926136416 2784 17176980 SGTC_1983 st071813 46.9 µM -0.184828732928268 0.442920741670896 no 1897 0.426681685250737 2798 11838595 SGTC_659 k018-0002 107 µM -0.184949565322969 0.442870363732704 no 1898 0.426634297020763 2823 6797879 YHR007C ERG11 SGTC_2350 9023895 38.85 µM -0.185716690720809 0.442550552240363 no 1899 0.426333469362077 2868 2997209 SGTC_3242 9133940 49.47 µM -0.185937699987464 0.442458421302749 no 1900 0.426246808685567 2885 17248444 SGTC_2291 7917025 104.35 µM -0.185979131537606 0.442441150302748 no 1901 0.426230563219285 2740 2964612 SGTC_2458 5808907 16.39 µM -0.187961343673754 0.441614981220428 no 1902 0.425453477150828 2773 2731747 SGTC_2273 7815444 169.05 µM -0.188304761808332 0.441471873185457 no 1903 0.4253188763731 2943 2824616 SGTC_3152 9099253 49.47 µM -0.189282878087549 0.44106431783559 no 1904 0.424935557031059 2835 25236131 SGTC_646 4092-0839 27.3 µM -0.189566939589654 0.440945968547243 no 1905 0.42482424789533 2868 877796 SGTC_1248 0469-0687 58.6 µM -0.190589689675419 0.440519901249893 no 1906 0.424423534285338 2849 4017482 SGTC_1502 4534-4282 27.7 µM -0.190820526152899 0.440423746624488 no 1907 0.424333103313666 2767 3278949 SGTC_3038 9091290 49.47 µM -0.194037136538109 0.439084239924825 no 1908 0.423073401856932 2884 25236843 SGTC_2089 5281248 129.67 µM -0.194740759780633 0.43879131953063 no 1909 0.422797950524445 2760 2737878 SGTC_376 3970-0862 59.1 µM -0.195679890608451 0.438400408901168 no 1910 0.422430362544148 2863 3135186 SGTC_1640 st009078 66.4 µM -0.197026013196402 0.437840193957538 no 1911 0.421903590587454 2881 690618 SGTC_2884 9058502 51.95 µM -0.197144730966452 0.437790793223032 no 1912 0.421857139998697 2858 6471554 SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM -0.197306271475331 0.437723574685372 no 1913 0.421793935943932 2758 2724278 An inhibitor of dopamine biosynthesis. SGTC_185 k048-0037 25.491 µM -0.197389718446668 0.437688852313087 no 1914 0.421761287417996 2841 6827589 SGTC_2083 5306046 65.942 µM -0.197504454171269 0.437641111441221 no 1915 0.421716398083513 2790 539837 SGTC_3347 9188721 44.724 µM -0.197541742779546 0.437625596062255 no 1916 0.421701809465283 2830 44118411 YKL104C | YBL026W GFA1 | LSM2 SGTC_1888 azatryptophan 97.5 µM -0.199141933554498 0.436959864990726 no 1917 0.421075859927437 2865 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides SGTC_1211 1056-0033 32.3 µM -0.199735332571621 0.436713037087767 no 1918 0.420843789563147 2792 6741922 SGTC_2814 7977482 42.97 µM -0.199747797629273 0.436707852435665 no 1919 0.420838914941637 2913 6456762 SGTC_1759 st043059 70 µM -0.199757824902666 0.436703681750926 no 1920 0.420834993655901 2770 669426 SGTC_975 1335-0046 28.5 µM -0.199764227983273 0.436701018495163 no 1921 0.420832489658407 2803 16486740 SGTC_2977 9011197 71.43 µM -0.199796750656164 0.436687491270112 no 1922 0.420819771346743 2988 2704722 SGTC_1165 k072-0275 30.3 µM -0.200749546177083 0.436291225907342 no 1923 0.420447208000436 2787 6153523 YGL055W OLE1 SGTC_332 4112-0506 40.9 µM -0.200883705249372 0.436235434598095 no 1924 0.420394754660566 2768 2790355 SGTC_2463 5473429 200 µM -0.200981400178455 0.436194808043223 no 1925 0.42035655891351 2823 5399405 SGTC_1037 k284-1091 78.7 µM -0.201595061162078 0.435939631789272 no 1926 0.420116653290737 2741 3334711 SGTC_1018 4259-0013 28.1 µM -0.201677296793204 0.435905438091201 no 1927 0.420084506212449 2910 6801262 SGTC_3278 9139605 49.47 µM -0.201960665092702 0.435787616800947 no 1928 0.419973737597429 2975 7958859 SGTC_5 0352-0601 109.883 µM -0.202026785670427 0.435760125442414 no 1929 0.419947891987845 2810 762456 SGTC_527 4476-4215 268 µM -0.202539492444817 0.435546964744677 no 1930 0.419747493802504 2783 4418754 SGTC_1392 3455-1037 33.9 µM -0.202863999665568 0.435412058732348 no 1931 0.419620666637832 2903 981132 SGTC_1370 2001-0092 44.6 µM -0.203197767740697 0.435273310585849 no 1932 0.41949022876301 2934 790957 SGTC_1108 betulinic acid 729.144 nM -0.203269588533727 0.435243455560403 no 1933 0.419462162071064 2798 64945 Apoptosis-inducing agent of unknown mechanism. SGTC_2258 7960471 200 µM -0.203465355078502 0.435162079676425 no 1934 0.419385660968587 2832 2974708 SGTC_610 4215-0184 155 µM -0.204199627449917 0.434856883155309 no 1935 0.419098751237338 2834 5605015 SGTC_163 TUB2.036 7.546 µM -0.20443143881262 0.434760540010628 no 1936 0.419008182146398 2830 15992207 YJR013W GPI14 SGTC_998 3996-0085 177 µM -0.204632132844507 0.434677132671457 no 1937 0.418929774115396 2843 715391 SGTC_1317 1273-0028 910 nM -0.205247391485528 0.434421452686797 no 1938 0.41868942223148 2802 5917803 YLR359W | YHR072W ADE13 | ERG7 SGTC_1261 0712-0010 12.7 µM -0.206095820258133 0.434068920355861 no 1939 0.418358031820591 2901 2840123 SGTC_3057 9095946 49.47 µM -0.20614043879735 0.434050382266404 no 1940 0.418340605729428 2738 24540043 SGTC_2245 6637752 200 µM -0.207004577581657 0.433691378950438 no 1941 0.418003141768448 2943 681890 SGTC_1856 st057054 55.7 µM -0.208506687498155 0.433067463188637 no 1942 0.417416680759397 3025 1266018 SGTC_539 4859-0462 2.54 µM -0.208956939691377 0.43288047904282 no 1943 0.417240926840447 2952 46499474 YNL221C | YBR257W POP1 | POP4 SGTC_1099 5-nonyloxytryptamine 2.85 µM -0.20953491531672 0.432640474972794 no 1944 0.417015340894468 2789 23581825 A 5-HT1D beta serotonin receptor agonist. SGTC_1166 k206-0078 225 µM -0.210157038962207 0.432382166231489 no 1945 0.416772554348839 2765 5404595 SGTC_1293 1000-1278 195 µM -0.210210545277347 0.432359951499137 no 1946 0.416751674750204 2921 678847 SGTC_2644 guaiazulene 100 µM -0.210580472367416 0.432206371158435 no 1947 0.416607325709764 2882 3515 A coloring agent. SGTC_1148 3909-7663 27.7 µM -0.21152022577393 0.431816265669299 no 1948 0.416240675673271 2929 4084526 SGTC_1730 st033808 45.1 µM -0.212397516385843 0.431452149397561 no 1949 0.415898461608166 2767 1045166 SGTC_331 k048-0133 24.5 µM -0.21307308291489 0.431171797646887 no 1950 0.415634979639395 2769 6813582 SGTC_454 lyso-paf C-16 6.67 µM -0.213765568762072 0.430884460576824 no 1951 0.415364938222275 2853 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_2337 9009472 200 µM -0.213841556734129 0.430852932682316 no 1952 0.415335308424096 2962 5742383 SGTC_2489 cantharidin 73.42 µM -0.214840949000214 0.43043831953863 no 1953 0.414945662787847 2764 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_1350 1495-0454 146 µM -0.214894724447467 0.430416012142932 no 1954 0.41492469904603 2955 1069057 SGTC_972 1319-0219 195 µM -0.216327670461979 0.42982167244125 no 1955 0.414366170882099 2857 23903702 SGTC_1284 0929-0043 16 µM -0.216739123739185 0.429651044241223 no 1956 0.414205828153977 2851 1239883 SGTC_349 k015-0014 24 µM -0.216762805653868 0.429641223835662 no 1957 0.414196599782086 2765 2196908 SGTC_1290 0986-0249 10.2 µM -0.217304733051102 0.429416509539219 no 1958 0.413985434392014 2855 53329 SGTC_2490 carminic acid 95.39 µM -0.217647270245876 0.429274485690538 no 1959 0.413851975459863 2750 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_3298 9116858 71.43 µM -0.218671437074287 0.428849897097354 no 1960 0.413453000210188 2935 2506942 SGTC_745 0469-0705 296 µM -0.220414773120494 0.428127352280342 no 1961 0.412774070513101 2974 3486736 SGTC_1799 st045822 46.1415 µM -0.22113487391772 0.427828968743797 no 1962 0.412493708440779 2930 3674992 SGTC_2439 5492030 7.2 µM -0.221415158851746 0.427712840026226 no 1963 0.41238459513395 2921 5722370 SGTC_752 1896-0090 130 µM -0.221905764771408 0.427509585398604 no 1964 0.412193621385675 2789 772567 SGTC_2570 licareol 100 µM -0.221965950839481 0.427484652052038 no 1965 0.41217019472773 2900 443158 SGTC_20 0481-0013 4.944 µM -0.222376459196143 0.427314598047186 no 1966 0.412010417946489 2802 182045 SGTC_1587 estradiol valerate 56.1 µM -0.222553106000187 0.427241425867629 no 1967 0.411941668515675 2957 13791 A steroid. SGTC_2379 9035213 200 µM -0.223383355774557 0.426897546136277 no 1968 0.411618578615891 2935 646551 SGTC_2414 st077232 92.9 µM -0.223852959756545 0.42670306624706 no 1969 0.41143585975983 2773 729801 SGTC_1551 6-bromo-3'-methylflavone 63.5 µM -0.226783887906909 0.425489668004562 no 1970 0.410295896448651 2977 688751 SGTC_169 k015-0017 16.025 µM -0.227485297294608 0.425199390123199 no 1971 0.410023200316118 2994 1840002 SGTC_1553 gossypol 38.6 µM -0.227658665698062 0.42512764795024 no 1972 0.409955804307807 2778 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_1630 st005209 31.3 µM -0.228916163620349 0.424607352785616 no 1973 0.409467038681774 2796 3367314 SGTC_3219 9131112 49.47 µM -0.229553492773698 0.424343705203648 no 1974 0.409219374581453 2871 17612988 YMR079W SEC14 SGTC_616 4092-0450 108 µM -0.23287092488248 0.422971913422249 no 1975 0.407930818193746 2878 787165 SGTC_962 1254-0300 21.5 µM -0.23484274292602 0.422156987892739 no 1976 0.407165395620103 2806 7340576 SGTC_1072 oxiconazole 14.9 nM -0.234917578952703 0.422126065722744 no 1977 0.407136352647974 2821 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_2545 solidagenone 89.61 µM -0.235039245630409 0.42207579420015 no 1978 0.407089136346899 2758 6708572 An anti ulcer agent SGTC_663 1486-0733 13.9 µM -0.235498112186177 0.421886206301736 no 1979 0.406911071957605 2822 722445 YPR165W RHO1 SGTC_3299 9121982 43.1275 µM -0.235629473170325 0.421831935786353 no 1980 0.406860100518741 2853 17594604 YPL160W CDC60 SGTC_2899 9053889 58.44 µM -0.236610761788474 0.421426572952908 no 1981 0.406479385277119 2893 6470052 SGTC_621 3584-0052 32.1 µM -0.236708564656029 0.421386175891023 no 1982 0.40644144506841 2882 2273927 SGTC_1909 st060837 51.5 µM -0.237754846456432 0.420954065466311 no 1983 0.40603562089366 2885 678937 SGTC_1477 0139-0234 16 µM -0.238476154062214 0.420656223565738 no 1984 0.405755904101532 2817 620880 SGTC_283 0987-0079 11.7 µM -0.239067344878234 0.420412143268974 no 1985 0.405526681334174 2919 411556 SGTC_2381 9035592 200 µM -0.240071443506511 0.419997659143492 no 1986 0.405137435849476 2885 4749657 SGTC_2373 9071805 200 µM -0.240206567462412 0.419941887785378 no 1987 0.405085061306923 2964 10149009 SGTC_363 0455-0021 3.06 µM -0.240288161620231 0.419908211212049 no 1988 0.405053435934206 2824 4597466 SGTC_2076 5212012 200 µM -0.24061161579131 0.419774716886252 no 1989 0.404928073273017 2784 604802 SGTC_2956 9076196 2.52 µM -0.240777795080883 0.419706135821435 no 1990 0.404863670173682 2943 16423868 SGTC_1113 artemisinin 1.17947 µM -0.241478564507095 0.419416959883661 no 1991 0.404592114016164 2932 2240 An anti-malaria and mitochondrial poison. SGTC_2316 5844804 197.44 µM -0.242039047243569 0.41918570524951 no 1992 0.404374953619383 2960 776813 SGTC_2455 5377712 9.75 µM -0.243642443910132 0.418524299757588 no 1993 0.403753876582766 2919 2243908 SGTC_1301 naphtanilide LB 4.81 µM -0.245178891920482 0.417890726790415 no 1994 0.403158959742453 2970 67238 An a1-adrenergic receptor antagonist or alpha blocker. SGTC_3294 9122953 26.2835 µM -0.245438151085028 0.417783839093277 no 1995 0.40305859594837 2816 16459826 SGTC_1954 st077032 68.9 µM -0.246281471567612 0.417436195903581 no 1996 0.402732175923982 2917 698907 SGTC_1453 4237-0541 195 µM -0.246548268371572 0.417326227304777 no 1997 0.402628922266502 2970 739892 SGTC_785 1270-0111 65.3 µM -0.248015163774487 0.416721716491739 no 1998 0.402061337143448 2815 6741994 SGTC_1866 st057638 64 µM -0.249455506997041 0.416128339436054 no 1999 0.401504226720953 2863 688802 SGTC_1441 4106-0040 13 µM -0.250168483308275 0.415834685784652 no 2000 0.401228528565867 2846 2904180 SGTC_923 1900-2434 73.3 µM -0.251711065326247 0.415199503335755 no 2001 0.400632201720394 2815 5910570 SGTC_1489 4065-0444 182 µM -0.252394713572084 0.414918071159785 no 2002 0.400367992935122 2965 2877968 SGTC_42 0133-0086 60.653 µM -0.252993188050214 0.414671737641653 no 2003 0.400136738578082 2795 162923 Model of phenazepam hydroxylation. SGTC_587 k089-0003 57 µM -0.253385827749494 0.414510144428332 no 2004 0.39998503910803 2840 9659696 SGTC_1339 1486-1321 22.7 µM -0.257701686584863 0.412734886266648 no 2005 0.398318572177283 2871 3469382 SGTC_2082 5219693 150 µM -0.259425258490845 0.412026419342872 no 2006 0.397653571590777 2850 2834649 SGTC_1947 st076332 61.6 µM -0.259722039374622 0.411904457681701 no 2007 0.397539095461283 2949 24208416 SGTC_32 0928-0142 34.1 µM -0.259839334586077 0.411856257735129 no 2008 0.397493854070398 2915 2244242 SGTC_2697 mebhydrolin 72.4 µM -0.260162513536937 0.411723461172144 no 2009 0.397369209354231 3018 22530 H1 Histamine receptor antagonist. YIL048W NEO1 SGTC_1976 st070609 63.5 µM -0.260215393665772 0.411701733307727 no 2010 0.397348815370284 2791 682556 SGTC_2080 5212524 12.4 µM -0.26084166928531 0.411444424140161 no 2011 0.397107304506979 2915 260183 SGTC_3020 9089140 49.47 µM -0.261177558021435 0.411306437882236 no 2012 0.396977791875619 2944 17217859 SGTC_584 0986-0246 15.4 µM -0.261747910727383 0.411072156756211 no 2013 0.39675790020358 2863 53315 YDR232W HEM1 SGTC_3095 9117207 49.47 µM -0.261917339019679 0.411002567591377 no 2014 0.396692585767375 2989 17015229 SGTC_2014 4013930 200 µM -0.262750446940129 0.410660426537903 no 2015 0.39637146570018 2904 64556 SGTC_1021 4476-0760 85.3 µM -0.264944497026992 0.409759699133033 no 2016 0.395526109560589 2886 746768 SGTC_1419 3993-2473 62.6 µM -0.265172593215655 0.409666085622427 no 2017 0.395438253406123 2899 704026 SGTC_1123 mangostin 811.285 nM -0.265436870138343 0.409557629528918 no 2018 0.395336468108788 2949 5281650 An antioxidant. SGTC_916 4466-0038 42 nM -0.26548450040636 0.409538083371485 no 2019 0.395318124243152 3059 5722064 YGL116W CDC20 SGTC_606 k015-0008 38.6 µM -0.265698863717779 0.409450117323617 no 2020 0.395235569280402 3012 1970475 SGTC_615 k087-0205 167 µM -0.265734987197517 0.409435294154771 no 2021 0.395221657975851 2887 9642773 SGTC_2159 5658611 73.75 µM -0.266397497003044 0.409163458093047 no 2022 0.394966546353075 2964 793844 SGTC_2369 9071472 200 µM -0.266445049987627 0.40914394818704 no 2023 0.39494823692956 3016 17296037 SGTC_226 1,3-diallylurea 8.28947 mM -0.266632162472246 0.409067182383803 no 2024 0.394876194877192 2968 74537 YKL182W FAS1 SGTC_1529 apigenin 74 µM -0.267687179337153 0.408634410677804 no 2025 0.394470059595465 3105 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_2871 9038510 12.99 µM -0.272254979508976 0.406761974213642 no 2026 0.392712985121863 3081 4945164 SGTC_112 phenothiazine 287.218 µM -0.272502809281585 0.406660444146168 no 2027 0.392617715743272 3013 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.  SGTC_1285 0929-0069 65.5 µM -0.272565116923001 0.406634919147949 no 2028 0.392593764789188 2916 1206237 SGTC_3155 9099265 49.47 µM -0.276596324781861 0.404984339054432 no 2029 0.391045043520504 2995 25236499 SGTC_442 cape 100 µM -0.277623040563517 0.404564218447849 no 2030 0.390650871677661 3026 5281787 SGTC_1860 st056228 74.6 µM -0.279388263312379 0.403842166460669 no 2031 0.389973438570761 3006 688679 SGTC_315 k915-0449 187 µM -0.280518744648131 0.403379922889644 no 2032 0.389539773193152 2941 20970215 YNL149C PGA2 SGTC_482 fipronil 114 µM -0.280594948683246 0.403348768598445 no 2033 0.389510545407799 2914 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels. SGTC_771 0250-0039 27.3 µM -0.280607913346529 0.403343468350993 no 2034 0.389505572919728 2912 3005115 SGTC_2598 perillyl alcohol 100 µM -0.281022406855025 0.40317402339696 no 2035 0.389346606942991 3068 10819 An apoptosis inducer. SGTC_1671 st016596 74.5 µM -0.28201925071127 0.402766588099791 no 2036 0.388964374625679 2942 2829167 SGTC_556 4058-0063 51.5 µM -0.282026343484401 0.402763689481754 no 2037 0.388961655339438 2954 6615692 SGTC_3265 9137266 49.47 µM -0.283052694685019 0.402344304867257 no 2038 0.388568221702896 2983 17224265 SGTC_2229 7354935 190 µM -0.283493065443585 0.402164396285925 no 2039 0.388399448350917 2994 318112 SGTC_214 4373-3496 70 µM -0.283540342335089 0.402145083068344 no 2040 0.38838133059893 2942 3779166 SGTC_3258 9138477 49.47 µM -0.284197947521664 0.401876467694137 no 2041 0.388129344144111 2932 4970355 SGTC_1423 4048-0112 5.59 µM -0.286542527243454 0.400919143170408 no 2042 0.387231313123413 2994 X1423 SGTC_1225 1216-0074 20.6 µM -0.286703396606492 0.400853479707419 no 2043 0.387169718306217 2921 4241466 SGTC_473 2-arachidonoylglycerol 10 µM -0.286896581691522 0.400774629353725 no 2044 0.387095753967514 2858 5282280 An endocannabinoid. SGTC_2964 9083345 53.42 µM -0.287639444322826 0.400471460501498 no 2045 0.386811374035235 2979 17741579 SGTC_1066 ketoconazole 628 nM -0.287961879580372 0.400339890450468 no 2046 0.386687959460202 3070 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W SGTC_1675 st018485 24.5 µM -0.288123316684514 0.400274020115367 no 2047 0.386626172470764 2979 3323024 SGTC_402 epigallocatechin gallate 10 µM -0.288186000243293 0.400248444436017 no 2048 0.386602182302137 2935 65064 An antioxidant. SGTC_1949 st076024 69.1 µM -0.288257515910955 0.400219265667742 no 2049 0.386574812449758 2849 2921930 SGTC_480 am 92016 50 µM -0.288361181935574 0.400176970373733 no 2050 0.386535139295009 2981 2129 K+ channel blocker. SGTC_1924 st058459 75.1 µM -0.28932111178216 0.399785378785125 no 2051 0.386167828981067 2865 688683 SGTC_1155 4088-0394 48.2 µM -0.290411140689676 0.39934083707919 no 2052 0.38575086087634 2887 2326248 SGTC_520 3584-0023 682 µM -0.290551862664616 0.399283456551831 no 2053 0.385697040192596 2966 1340790 SGTC_99 0109-0120 622.8 µM -0.29081357130946 0.399176748514895 no 2054 0.38559695266435 3127 759414 SGTC_679 0422-0091 41.4 µM -0.292224276447962 0.398601683177771 no 2055 0.385057575698763 2918 627384 YHR062C RPP1 SGTC_2920 7982904 15.77 µM -0.294209003280204 0.39779299429809 no 2056 0.384299100663095 3039 6456808 SGTC_2688 kanamycin b 96.69 µM -0.295564887292119 0.397240783361559 no 2057 0.383781196004004 3072 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis. SGTC_3256 9138902 49.47 µM -0.295777121300443 0.397154365419228 no 2058 0.383700148109309 2927 17228773 SGTC_2399 5884133 200 µM -0.296423596682698 0.396891163183857 no 2059 0.383453303541454 2934 722445 SGTC_865 0488-0499 301 µM -0.297193216466352 0.39657788589232 no 2060 0.383159500259433 3089 9634651 SGTC_3080 9117754 49.47 µM -0.298415161155028 0.396080624855989 no 2061 0.382693159496221 3151 9550191 SGTC_3051 9093778 49.47 µM -0.298647552640154 0.395986074027341 no 2062 0.382604489252266 2971 17217378 SGTC_2892 9047358 58.44 µM -0.299848515701834 0.39549754768581 no 2063 0.382146353389184 2980 6466771 SGTC_2954 9074818 52.69 µM -0.300138375522502 0.395379663412052 no 2064 0.38203580416837 3111 16648742 SGTC_2522 biochanin a 4.94 µM -0.300241897215324 0.395337564071563 no 2065 0.381996324508842 3060 5280373 A possible chelator. SGTC_733 4069-0007 56.1 µM -0.301276592149705 0.394916850140133 no 2066 0.381601794471586 2962 5717425 YNL287W SEC21 SGTC_113 0099-0221 2.5 µM -0.30158538215475 0.394791317755078 no 2067 0.381484076393896 3131 89219 SGTC_2591 skatole 100 µM -0.302338101694178 0.394485360505221 no 2068 0.381197167793543 3066 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite. SGTC_1338 1486-1223 76 µM -0.303239595201627 0.3941190168905 no 2069 0.380853638037708 3009 3444526 SGTC_1999 st074831 12.5 µM -0.304091436111186 0.393772936859287 no 2070 0.380529115544526 2966 17112523 SGTC_1186 1319-0216 26 µM -0.304488636407176 0.393611593730424 no 2071 0.380377824424922 3087 4565136 SGTC_301 4119-0100 24.5 µM -0.304813023864986 0.393479840791537 no 2072 0.380254280833913 2961 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1 SGTC_601 0986-0029 62.9 µM -0.305691309378593 0.393123178334283 no 2073 0.37991984543883 2966 24747981 SGTC_2596 sinensetin 100 µM -0.306935463655345 0.392618094022305 no 2074 0.379446247493448 2984 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets. SGTC_1845 st056753 3.01 µM -0.307395322091415 0.392431452856929 no 2075 0.379271244187659 2894 5375839 SGTC_2012 4023501 200 µM -0.307914940189374 0.392220587014317 no 2076 0.37907352856848 3028 3477460 SGTC_774 k060-0086 136 µM -0.308835591643737 0.391847055857294 no 2077 0.378723296739213 3127 5911235 SGTC_2265 7929201 200 µM -0.308891737456329 0.391824279327974 no 2078 0.378701941113849 2899 1265108 SGTC_117 lucigenin 22.078 µM -0.309862203195839 0.391430651604209 no 2079 0.37833287327343 3022 65100 An acridine derivative; a dye stuff and potential carcinogen. SGTC_403 arphamenine a 50 µM -0.310960336585584 0.390985375046002 no 2080 0.377915387302097 2954 5487158 An arginine aminopeptidase inhibitor. SGTC_589 1227-0070 34.1 µM -0.311627740123504 0.390714822723501 no 2081 0.37766172488202 3067 2841384 SGTC_804 1595-0054 20.9 µM -0.31216737215385 0.390496105136789 no 2082 0.377456663595093 2970 761523 Stimulates phospholipase C. SGTC_3091 9116372 49.47 µM -0.313796538354521 0.389836000271892 no 2083 0.376837786843185 3123 17169793 SGTC_393 acivicin 6.25 µM -0.313816530240193 0.389827901937034 no 2084 0.376830194420983 2938 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1 SGTC_2983 9022671 12.99 µM -0.313916652019088 0.389787345217221 no 2085 0.37679217136995 3148 6405161 SGTC_1418 3966-3099 2.4 µM -0.31473647096864 0.38945530313296 no 2086 0.376480875325574 3051 740335 SGTC_1154 4088-0362 150 µM -0.314872492574836 0.389400219623526 no 2087 0.376429233894534 2934 6618304 SGTC_336 4111-0029 111 µM -0.315331936248179 0.389214179074025 no 2088 0.376254819663538 2989 3131175 SGTC_1437 4092-1038 11.6 µM -0.315542995908901 0.389128724103266 no 2089 0.376174705559947 2971 3977136 SGTC_2791 5663188 71.43 µM -0.315569016864564 0.389118188970011 no 2090 0.376164828885402 3137 54690634 SGTC_3042 9091578 49.47 µM -0.316751149450507 0.388639663722434 no 2091 0.375716216972341 3027 25236497 SGTC_2547 epiafzelechin trimethyl ether 100 µM -0.317438395500242 0.388361545305156 no 2092 0.37545548856495 2898 6708630 An antioxidant. SGTC_2275 7947463 200 µM -0.31798112662504 0.388141950399274 no 2093 0.375249626626829 3113 1225414 SGTC_3012 9080433 71.4286 µM -0.318242392081815 0.388036252304516 no 2094 0.37515053936597 3072 17688859 SGTC_85 0868-0259 160.055 µM -0.31847159744624 0.38794353133652 no 2095 0.375063617965595 3015 83173 SGTC_2910 7948405 25.97 µM -0.318988568699057 0.387734423239409 no 2096 0.374867590595467 3133 2971328 SGTC_1142 3253-1408 9.78 µM -0.319904471178386 0.387364032656602 no 2097 0.37452037416958 3075 256655 SGTC_1499 4480-0877 67.3 µM -0.32001385594583 0.387319804347705 no 2098 0.374478913461885 2965 2861909 SGTC_2830 7992007 71.43 µM -0.322098911431104 0.386477019536545 no 2099 0.373688881463369 2817 1952075 SGTC_2840 9008771 71.43 µM -0.323951024915705 0.385728839189392 no 2100 0.372987556420681 3086 2992978 SGTC_2653 dihydrofissinolide 100 µM -0.324137387184035 0.385653579712693 no 2101 0.372917011364503 3044 6857746 SGTC_2605 digitonin 300 nM -0.324399042169291 0.385547921719237 no 2102 0.372817972404064 3115 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_2193 5925765 200 µM -0.324458570868466 0.385523884826987 no 2103 0.372795441385183 3085 877370 SGTC_995 3931-2021 34.6 µM -0.32461840384508 0.385459348584852 no 2104 0.372734948350767 3075 730143 SGTC_15 0266-0086 27.098 µM -0.324832141947731 0.385373051863982 no 2105 0.372654058395031 3072 1712902 YIL048W NEO1 SGTC_2485 5633444 17.78 µM -0.32742834736429 0.384325288708691 no 2106 0.371671964470071 3066 5724239 SGTC_2864 9034755 47.6 µM -0.327775096187899 0.38418541338367 no 2107 0.371540859187412 3001 4930451 SGTC_3336 9143619 71.43 µM -0.327935084318105 0.384120880709191 no 2108 0.371480372904415 3103 45595730 SGTC_1676 st018489 23.4 µM -0.328988537860115 0.383696040888577 no 2109 0.371082175856338 2995 3696235 SGTC_1306 1185-0270 9.02 µM -0.329500040320699 0.383489811057009 no 2110 0.370888881739176 3101 1548076 SGTC_2040 5100729 123 µM -0.329705136012397 0.383407128932759 no 2111 0.370811386291795 2984 11840 YJR013W | YDR381W GPI14 | YRA1 SGTC_2 0422-0095 29 µM -0.330009882787101 0.383284283352505 no 2112 0.370696247341782 3026 6790840 SGTC_2471 5466956 24.79 µM -0.330198143359527 0.383208400047195 no 2113 0.370625124811908 2995 724419 SGTC_127 0180-0333 59.125 µM -0.330290171828754 0.383171307216819 no 2114 0.370590359196269 3006 771601 SGTC_1543 azetidyl-2-carboxylic acid 198 µM -0.330909084817168 0.382921877093105 no 2115 0.370356579760125 2960 16486 A toxic proline analog. SGTC_669 0108-0021 26.2 µM -0.33095368142097 0.382903905945383 no 2116 0.370339736318083 3260 17201 SGTC_755 1995-0008 37.3 µM -0.332646455118946 0.382221953568049 no 2117 0.369700586156226 3107 689533 SGTC_3168 9103419 49.47 µM -0.333860873107719 0.381732936852196 no 2118 0.369242273031356 3071 16649256 SGTC_68 0986-0284 82.829 µM -0.334774676516307 0.381365094704596 no 2119 0.368897532273571 3164 423278 YIL048W NEO1 SGTC_1841 st054148 70 µM -0.33525681142213 0.381171059421154 no 2120 0.368715684914941 3073 675442 SGTC_1650 st011916 45.8 µM -0.336738352216062 0.380575000165268 no 2121 0.368157074610434 3126 242528 SGTC_1646 st011709 75.6 µM -0.337545568594136 0.380250356906169 no 2122 0.367852833397368 3107 5757843 SGTC_1151 3909-8316 15.3 µM -0.337581663774881 0.38023584224989 no 2123 0.367839230997632 3112 800431 SGTC_3228 9131799 49.47 µM -0.338637290631184 0.379811426428357 no 2124 0.367441493409142 3066 17015818 SGTC_1897 st060201 15 µM -0.340097102212493 0.379224746291292 no 2125 0.366891701976075 3015 611878 SGTC_2939 9044578 71.43 µM -0.34037716859683 0.379112222839141 no 2126 0.36678625507997 2965 2653634 SGTC_2130 NSC 7 2.4545 µM -0.343100078471254 0.378018763071597 no 2127 0.365761586047 3111 21448 SGTC_1531 st059297 52.4 µM -0.344938833463404 0.377280911911426 no 2128 0.365070177674826 3113 7566702 SGTC_2004 4023728 41.89 µM -0.345171437896694 0.377187604816136 no 2129 0.364982744984746 3174 360084 YDR527W RBA50 SGTC_1826 st055655 41.6 µM -0.34746200325307 0.376269149668472 no 2130 0.364122129695952 3089 676168 SGTC_372 0155-0182 15.9 µM -0.347468193925785 0.376266668321582 no 2131 0.364119804651338 2975 771486 SGTC_2274 7947094 46.08 µM -0.348471277704052 0.375864679662645 no 2132 0.363743140376292 3020 2971028 SGTC_2005 4024620 188 µM -0.348932430470786 0.375679916553152 no 2133 0.363570018759147 3001 236743 SGTC_1242 0402-0103 60.1 µM -0.349188844830541 0.375577195215085 no 2134 0.363473770149409 2988 432868 SGTC_2124 5246320 200 µM -0.349585930187006 0.375418137524436 no 2135 0.363324735779628 3099 579342 SGTC_1872 amphotericin b 148 nM -0.350221963524345 0.375163410253621 no 2136 0.363086062390375 3126 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1 SGTC_1425 4048-4433 7.33 µM -0.350516472565674 0.37504547970297 no 2137 0.362975565003512 3116 23734946 SGTC_2821 7996764 71.43 µM -0.352330122169188 0.374319496013822 no 2138 0.362295350204374 3246 2987135 SGTC_2235 salicylic acid 500 µM -0.352436796495652 0.374276809316386 no 2139 0.362255355185016 3072 338 A COX inhibitor and kinase inhibitor. SGTC_1427 4048-4900 550 nM -0.353225717872078 0.373961163165298 no 2140 0.361959614453841 3143 24132586 SGTC_142 0335-0849 62.6745 µM -0.353745618706693 0.373753197867965 no 2141 0.361764765728733 3150 3889043 YPR107C YTH1 SGTC_2727 riluzole 51.77 µM -0.354091679557478 0.373614790592644 no 2142 0.361635088710195 3063 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.  SGTC_3201 9113999 49.47 µM -0.355529758343656 0.373039804778515 no 2143 0.361096377632176 3200 16649224 SGTC_1336 1486-0901 104 µM -0.356782590307721 0.37253911638487 no 2144 0.360627285291056 3089 5006114 SGTC_1267 0828-0272 9.49 µM -0.357652716888741 0.372191501045242 no 2145 0.360301610956032 3174 745334 SGTC_2799 7812892 81.82 µM -0.3582022798776 0.371972004407039 no 2146 0.360095970598574 3193 20205235 SGTC_1463 k081-0032 34.1 µM -0.359236626705691 0.371558996944943 no 2147 0.359709039349073 3091 977755 SGTC_506 n9-isopropylolomoucine 153 µM -0.360552858314157 0.371033648629727 no 2148 0.359216867775837 3165 6610355 SGTC_1814 st052110 31.539 µM -0.36129385677079 0.37073799910817 no 2149 0.358939892802161 3172 674163 SGTC_3177 9107506 49.47 µM -0.3615498146993 0.370635892678614 no 2150 0.358844236490384 3133 8897194 SGTC_1462 k081-0014 26.5 µM -0.361714813604396 0.370570076342734 no 2151 0.358782577975378 3051 3270634 SGTC_2641 levomentholum 100 µM -0.362950993323345 0.370077097814354 no 2152 0.358320746581506 3100 16666 SGTC_3026 9090633 49.47 µM -0.363729287044761 0.369766829945685 no 2153 0.358030085650276 3034 25236842 SGTC_1895 st058434 18.3 µM -0.365356063220087 0.369118587332668 no 2154 0.357422817037102 3201 5393175 SGTC_642 0335-0876 158 µM -0.366232085306582 0.368769661439811 no 2155 0.35709595110599 3058 6812350 SGTC_824 1304-0008 100 µM -0.366763738506378 0.368557952864072 no 2156 0.356897629002626 3053 768245 SGTC_357 1325-0123 420 µM -0.367511248643304 0.368260355807893 no 2157 0.356618851399278 3169 1098503 SGTC_2759 disulfiram 3.38 µM -0.368073378683674 0.368036613907203 no 2158 0.356409260176796 3017 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_640 3381-0960 37.1 µM -0.36898936372895 0.367672124730226 no 2159 0.356067826383739 3125 1745025 SGTC_726 3448-4391 34.2 µM -0.369180218780755 0.367596194591922 no 2160 0.355996699603434 3229 1356692 SGTC_2872 9044037 25.97 µM -0.369218856206587 0.367580823634459 no 2161 0.35598230103618 3030 6465195 SGTC_2532 xanthone 78.9 µM -0.369439080156578 0.367493216958327 no 2162 0.355900236619776 3163 7020 An insecticide. SGTC_1146 3579-1023 7 µM -0.369702755204266 0.367388334192984 no 2163 0.355801989336649 3176 X1146 SGTC_501 nsc-95397 161 µM -0.370047956668676 0.367251037389698 no 2164 0.355673379181651 3220 262093 SGTC_3194 9111903 49.47 µM -0.370361574175403 0.367126317170638 no 2165 0.355556550361125 3255 17087251 SGTC_1524 corynanthine 62.1 µM -0.371472468780602 0.366684646606733 no 2166 0.355142829033967 3214 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist. SGTC_3046 9092212 49.47 µM -0.371522406024281 0.366664796648659 no 2167 0.355124235323355 3119 25236637 SGTC_2116 5511452 16.8835 µM -0.372683154896195 0.36620350178977 no 2168 0.354692137574194 3186 870744 SGTC_868 0527-0199 213 µM -0.373891797936336 0.365723378656007 no 2169 0.354242409464606 3086 2849450 SGTC_1440 4100-1550 40 µM -0.374697145253692 0.365403577984249 no 2170 0.353942857800961 3104 742806 SGTC_1836 st055642 81 µM -0.374782975862456 0.365369500455251 no 2171 0.353910938141679 3079 8571 SGTC_697 0508-1955 564 µM -0.374906528991254 0.365320447731401 no 2172 0.353864991607121 3227 6243113 SGTC_2645 abamectin 100 µM -0.376028412273054 0.364875141627966 no 2173 0.353447886783937 3167 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels. SGTC_3213 9129884 49.47 µM -0.37606865431082 0.364859171846137 no 2174 0.353432928468199 3125 17190742 SGTC_1664 st014217 9.02 µM -0.376149765377549 0.364826984177781 no 2175 0.353402779466625 3151 3982782 SGTC_2614 arthonioic acid 13.39 µM -0.376287340197406 0.364772391923455 no 2176 0.353351644978706 3061 6710684 SGTC_1986 st071812 45 µM -0.377323680349944 0.364361241009994 no 2177 0.352966538088132 3153 11838594 SGTC_370 0180-0345 38.7 µM -0.377815683664619 0.364166101374238 no 2178 0.352783760969539 2971 3989527 SGTC_898 1000-0849 28.3 µM -0.378522108436764 0.363885978924133 no 2179 0.352521386617422 3151 6751807 SGTC_558 k064-0027 21.3 µM -0.379428768095055 0.363526562831921 no 2180 0.352184745514347 3151 5088526 SGTC_618 k072-0232 33.2 µM -0.381007129300604 0.362901158895383 no 2181 0.351598979211278 3133 5872756 YGL099W LSG1 SGTC_964 1287-0107 19.4 µM -0.382066648055764 0.36248154405012 no 2182 0.351205964789604 3231 51516812 YPR165W RHO1 SGTC_1327 1436-0082 2.18 µM -0.38269900768626 0.362231181190525 no 2183 0.350971475149805 3103 15992205 SGTC_1507 4075-3230 155 µM -0.383605049085244 0.361872565377856 no 2184 0.3506355985942 3142 659771 SGTC_988 1497-1057 103 µM -0.383837759411519 0.361780477000669 no 2185 0.350549349905521 3190 3533044 SGTC_1594 piperine 70.1 µM -0.385467735778072 0.361135685647352 no 2186 0.349945453119654 3070 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_2503 beta-caryophyllene alcohol 24.72 µM -0.386089038165034 0.360890012533747 no 2187 0.349715363963303 3199 61125 An anti-inflammatory. SGTC_1299 1079-1439 3.74 µM -0.387158665722769 0.360467198809101 no 2188 0.349319374257771 3098 323161 SGTC_1687 st020778 55.3625 µM -0.389650134253105 0.359483006798384 no 2189 0.348397637339225 3099 4259299 SGTC_306 1672-3436 11.6 µM -0.390272160703129 0.359237435927404 no 2190 0.348167653458918 3184 6797378 SGTC_2190 6049624 200 µM -0.391170762150941 0.358882778231965 no 2191 0.347835509191185 3170 2265554 SGTC_3063 1327-0034 4 µM -0.391203615282209 0.358869814145736 no 2192 0.347823368110271 3174 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_166 k072-0058 166.424 µM -0.391483488164759 0.358759380849032 no 2193 0.347719945657273 3231 5846229 SGTC_1514 1189-1591 158 µM -0.392532498435715 0.358345563547209 no 2194 0.347332401927241 3263 767698 YMR146C TIF34 SGTC_2430 5571206 200 µM -0.3951185279518 0.357326128659323 no 2195 0.346377707863541 3253 1731771 SGTC_1000 4048-0884 8.67 µM -0.395191033762612 0.357297560880046 no 2196 0.346350954651994 3220 13040088 SGTC_877 0771-0151 33.1 µM -0.395316381799397 0.357248174793403 no 2197 0.346304705511397 3171 6166523 SGTC_2715 st079500 56.4 µM -0.396135936881898 0.356925335850319 no 2198 0.346002374204948 3062 28246688 SGTC_2633 5,7-dihydroxyisoflavone 100 µM -0.396374932107629 0.356831210188676 no 2199 0.345914228088136 3237 5377381 SGTC_2212 7123476 200 µM -0.397088380451672 0.35655027820773 no 2200 0.345651144059492 3122 1085715 SGTC_1731 st035964 63 µM -0.398150031113167 0.356132379932512 no 2201 0.345259798436987 3098 6739575 SGTC_1541 2',3',6-trimethoxyflavone 64 µM -0.399513207824978 0.355596045117135 no 2202 0.344757546859868 3205 688801 SGTC_2397 5161689 200 µM -0.399696025255437 0.355524138256763 no 2203 0.344690210015736 3314 2259942 SGTC_181 1447-1644 8.07 µM -0.39976602651918 0.35549660629646 no 2204 0.34466442786771 3205 534600 SGTC_790 1575-0012 79.1 µM -0.405234710160193 0.353348077496674 no 2205 0.34265249660871 3253 378741 YLR208W SEC13 SGTC_3129 9127257 49.47 µM -0.406928068415888 0.352683735983378 no 2206 0.342030410022371 3108 837894 SGTC_1953 st076800 12.1 µM -0.407609907356438 0.352416362322103 no 2207 0.341780044758062 3125 297591 SGTC_2621 lithochol-11-enic acid 100 µM -0.40779409837203 0.352344146879198 no 2208 0.341712423368179 3245 6708711 SGTC_1175 0741-0056 27.6 µM -0.408104497872891 0.352222461145186 no 2209 0.341598479000235 3302 765927 SGTC_470 aa-861 153 µM -0.408340030929323 0.352130135353507 no 2210 0.341512026941423 3135 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor. SGTC_352 k048-0007 5.11 µM -0.409370809319561 0.351726186676932 no 2211 0.341133779129796 3221 6811911 SGTC_2989 9073649 71.4286 µM -0.412013627364964 0.350691266033613 no 2212 0.340164717468293 3251 21367202 SGTC_89 0302-0250 142.109 µM -0.412787551598293 0.350388408540503 no 2213 0.339881136324977 3192 4203518 YLR208W SEC13 SGTC_2289 7946404 165.07 µM -0.412878592665709 0.350352787955039 no 2214 0.339847783029286 3099 1246120 YPR165W RHO1 SGTC_900 1112-0045 141 µM -0.412911627581633 0.350339863090986 no 2215 0.339835680852439 3166 56211 YIL048W NEO1 SGTC_3238 9133470 49.47 µM -0.414187995226215 0.349840618890537 no 2216 0.339368216435474 3252 3534688 SGTC_515 4092-1064 102 µM -0.415383971063499 0.349373054972414 no 2217 0.33893041938719 3332 717353 SGTC_1670 st016595 4.04 µM -0.416334407088842 0.349001647149567 no 2218 0.338582659293378 3202 597879 SGTC_720 r052-1644 49.9 µM -0.416347338357254 0.348996594913377 no 2219 0.338577928750866 3209 1422863 YOR257W CDC31 SGTC_1313 1220-0047 237 µM -0.416867010391909 0.348793581628416 no 2220 0.338387842371206 3187 3528706 SGTC_849 0386-0493 241 µM -0.416916396899781 0.348774290716863 no 2221 0.338369779845531 3122 726119 SGTC_2712 st079126 47.7 µM -0.417856626966503 0.348407101165239 no 2222 0.338025972903999 3109 3152970 SGTC_897 1000-0139 31.4 µM -0.418882865009566 0.348006484879494 no 2223 0.337650870217925 3279 6151020 SGTC_63 0099-0242 26.702 µM -0.418933140678161 0.347986862937509 no 2224 0.337632497979507 3248 3898502 YLR359W ADE13 SGTC_693 4161-2696 114 µM -0.419031423522606 0.347948505592515 no 2225 0.337596583595657 3234 805759 SGTC_233 rapamycin 362 pM -0.41983757548465 0.347633943321752 no 2226 0.337302056484225 3222 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C SGTC_613 3914-0030 117 µM -0.42030472303317 0.347451709299425 no 2227 0.337131430022707 3050 1145395 SGTC_682 0kpi-0099 17 µM -0.422269620387985 0.346685590249558 no 2228 0.336414114947036 3245 1714895 YML126C ERG13 SGTC_2999 9069765 71.4286 µM -0.423233867283281 0.346309856625066 no 2229 0.336062319709852 3186 2097066 SGTC_775 4577-0580 57.3 µM -0.424467604547196 0.345829332465014 no 2230 0.335612413130746 3348 2006902 SGTC_2208 7283366 200 µM -0.426194598274603 0.345157108558076 no 2231 0.334983026629011 3244 898663 SGTC_854 0422-0053 192 µM -0.42715218914099 0.344784581263161 no 2232 0.334634241185096 3231 3596728 SGTC_1515 3460-0031 42.1 µM -0.427795018916152 0.344534588434757 no 2233 0.334400181870252 3208 2876596 SGTC_1379 2144-0755 36.5 µM -0.428118981594139 0.344408626920184 no 2234 0.334282248927172 3334 5392327 SGTC_1882 5615643 20 µM -0.429093596492694 0.344029786213723 no 2235 0.333927556086954 3236 2253075 SGTC_1686 st019653 115.5 µM -0.429235625984485 0.34397459125635 no 2236 0.333875879487408 3276 97252 SGTC_2178 5812956 200 µM -0.430006221061323 0.343675183525213 no 2237 0.333595557913872 3145 5403383 SGTC_602 3130-1533 38.1 µM -0.431464770508134 0.343108745867747 no 2238 0.333065231574258 3264 720941 SGTC_3221 9128209 49.47 µM -0.432014032508314 0.342895527471978 no 2239 0.332865607182324 3179 16460723 SGTC_1455 4262-0120 131 µM -0.43215975783011 0.342838966652586 no 2240 0.332812652557273 3330 1529587 SGTC_1851 st056236 18.9 µM -0.432188184696824 0.34282793365551 no 2241 0.332802323004326 3323 5393171 SGTC_1215 3852-0577 11.2 µM -0.433111934329913 0.342469482194288 no 2242 0.332466726527648 3312 2884876 SGTC_1931 st074438 57.1 µM -0.434875494001117 0.341785545253862 no 2243 0.331826401645727 3221 2787313 SGTC_1705 st027868 56.3335 µM -0.436660636097606 0.34109376678858 no 2244 0.3311787404245 3229 292948 SGTC_1486 3970-0793 4.53 µM -0.437406424736857 0.340804916644881 no 2245 0.330908312792216 3256 2844330 SGTC_2981 9013952 38.96 µM -0.437993770344043 0.34057749847576 no 2246 0.330695399674875 3192 2996344 SGTC_684 1140-0066 328 µM -0.438398594586459 0.340420785670135 no 2247 0.330548682534541 3246 6813534 SGTC_2030 5175110 200 µM -0.439190689839165 0.340114234860337 no 2248 0.330261685256993 3293 2831986 SGTC_2268 7933382 153.85 µM -0.439707557177751 0.339914257663705 no 2249 0.330074464219998 3263 935025 YOR257W CDC31 SGTC_400 oxethazaine 37.5 µM -0.439923922599714 0.339830558739438 no 2250 0.329996104402089 3241 4621 A local anesthetic. SGTC_2610 ononetin 44.17 µM -0.441656152011141 0.339160747069842 no 2251 0.329369021988859 3245 259632 SGTC_2618 avocadyne 43.43 µM -0.442399650638306 0.338873409625836 no 2252 0.329100015894505 3181 3015189 SGTC_3338 9144300 39.5675 µM -0.442680322358876 0.33876496371876 no 2253 0.328998488731699 3216 4901274 SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM -0.443058751904275 0.338618767312531 no 2254 0.32886161967716 3177 2333 A French combination drug. SGTC_1047 2043-3044 82 µM -0.444429604511794 0.338089377789828 no 2255 0.328366006804866 3198 669592 SGTC_343 4130-2827 29.8 µM -0.445677639432787 0.337607695663214 no 2256 0.327915059459589 3221 1118244 SGTC_7 0192-1582 4.227 µM -0.445708652709898 0.337595729396088 no 2257 0.327903856749927 3223 252616 SGTC_760 0568-0725 82.9 µM -0.445800897093784 0.337560138483395 no 2258 0.327870536870167 3302 3916171 SGTC_1987 st072290 61.9 µM -0.445827086193391 0.337550034133489 no 2259 0.327861077274055 3216 54697379 SGTC_1448 4255-0083 152 µM -0.446614313904959 0.33724635849065 no 2260 0.32757677940098 3325 5399660 SGTC_3024 9090631 49.47 µM -0.446944319809447 0.337119089163599 no 2261 0.327457631435172 3284 25236383 SGTC_2211 7117706 200 µM -0.451394386309518 0.335404712194832 no 2262 0.325852664276995 3270 822771 SGTC_118 0083-0097 135.343 µM -0.45149929193409 0.335364338712197 no 2263 0.325814867626988 3295 5207356 SGTC_55 0767-0285 6.563 µM -0.451796900338268 0.33524981289819 no 2264 0.3257076514647 3295 3116166 SGTC_2051 5263410 176 µM -0.452725565927931 0.334892541817964 no 2265 0.325373183858424 3331 227584 SGTC_1287 0971-0001 34.6 µM -0.453102132876457 0.334747713615411 no 2266 0.325237599796093 3259 4665869 SGTC_3280 9140961 49.47 µM -0.455455712629014 0.333843080987776 no 2267 0.32439071102852 3165 4901226 SGTC_1726 st035556 14.5795 µM -0.456263625800533 0.333532769982418 no 2268 0.324100208576194 3370 5919439 SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM -0.456735395138705 0.333351620952372 no 2269 0.32393062332899 3293 279621 SGTC_194 1486-1323 56.904 µM -0.45708926810001 0.333215767037399 no 2270 0.32380344185372 3236 5178754 SGTC_3355 9151058 44.0485 µM -0.457418220278972 0.333089499979909 no 2271 0.323685235322698 3312 17015728 SGTC_1847 st056231 15 µM -0.459499297782446 0.332291125151951 no 2272 0.322937828103203 3193 5393180 SGTC_1189 1431-2119 7.28 µM -0.460155829376826 0.332039414065851 no 2273 0.322702186604543 3306 3107275 SGTC_1090 efavirenz 20.7 µM -0.46055315663961 0.331887117482925 no 2274 0.322559612968186 3251 64139 A non-nucleoside reverse transcriptase inhibitor. SGTC_3050 9093513 49.47 µM -0.461241990522484 0.331623151471886 no 2275 0.322312499329216 3255 25236664 SGTC_1825 st052143 62.6 µM -0.461279610212685 0.331608737746942 no 2276 0.322299005826455 3346 674173 SGTC_124 0136-0217 7.121 µM -0.462437589493394 0.331165188014484 no 2277 0.321883774198002 3391 3976905 SGTC_1457 k015-0032 57.3 µM -0.462617898821586 0.331096144033156 no 2278 0.321819138337389 3277 4302660 SGTC_3296 9122258 64.045 µM -0.464472550156657 0.330386295323284 no 2279 0.321154610835566 3299 4730474 SGTC_569 4130-2812 160 µM -0.46536901539647 0.330043400953232 no 2280 0.320833609497196 3263 743552 SGTC_508 roscovitine 141 µM -0.465905754807337 0.329838168563829 no 2281 0.320641480870484 3282 160355 A CDKinase inhibitor. SGTC_2351 9026858 72.31 µM -0.466062073403425 0.329778406841554 no 2282 0.320585534857654 3164 1409300 SGTC_2300 7976697 71.57 µM -0.468600010410904 0.328808744194698 no 2283 0.319677784927017 3157 2236109 SGTC_2602 kawain 100 µM -0.468835976736193 0.328718647582954 no 2284 0.319593441043635 3312 5369129 SGTC_3147 9097027 49.47 µM -0.468885452376079 0.328699758066965 no 2285 0.319575757637262 3213 25236841 SGTC_321 4534-3890 65.3 µM -0.469061300847643 0.328632623669943 no 2286 0.319512909825412 3300 699746 SGTC_430 0958-0115 16.4 µM -0.469498504604048 0.328465734559664 no 2287 0.319356676745334 3206 6833180 SGTC_850 0388-0143 75.9 µM -0.471954513817443 0.327528865241575 no 2288 0.318479627986122 3227 67273 SGTC_2428 5615643 7.78 µM -0.472474193236675 0.327330767203784 no 2289 0.318294178899227 3299 2253075 SGTC_2370 9071495 200 µM -0.47249551056938 0.327322642228368 no 2290 0.318286572719925 3298 21791103 SGTC_2073 5212005 126 µM -0.473024344355092 0.327121106551646 no 2291 0.318097905511504 3235 691789 SGTC_2510 benzyl isothiocyanate 8.31 µM -0.474916454197874 0.326400446873196 no 2292 0.317423261483527 3296 2346 DNA damaging agent; causes G2/M arrest. SGTC_1253 0550-0034 176 µM -0.475930753258287 0.326014390879847 no 2293 0.317061855944664 3328 5969915 SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM -0.476103085071645 0.325948817568252 no 2294 0.317000469614292 3236 4174840 SGTC_3110 9122132 49.47 µM -0.47655255936694 0.325777815175338 no 2295 0.316840386038053 3412 918317 SGTC_2760 etidronate 98.04 µM -0.476779188551888 0.325691608049167 no 2296 0.316759683387218 3226 3305 A chelator and antioxidant. SGTC_667 1498-1044 59 µM -0.478285870684036 0.325118720709691 no 2297 0.31622337572978 3265 6739982 SGTC_268 camptothecin 39.6153 µM -0.478926402617373 0.324875295654678 no 2298 0.315995493601606 3326 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_1688 st021091 57.6 µM -0.47936002539466 0.324710545909431 no 2299 0.315841263241378 3356 3656366 SGTC_2217 6934799 96.0675 µM -0.479452270107635 0.324675503064791 no 2300 0.315808457901326 3314 675606 SGTC_955 1216-0110 33 µM -0.479819047583097 0.324536183321971 no 2301 0.315678033780228 3281 3619719 SGTC_50 0929-0078 56.389 µM -0.480676069259418 0.324210740962915 no 2302 0.315373370917814 3206 1377751 SGTC_2453 5731132 22.18 µM -0.481246741355813 0.323994110422376 no 2303 0.315170572128395 3367 1362040 SGTC_1235 benzylparaben 21.5 µM -0.482766725015439 0.32341740643251 no 2304 0.314630689904963 3316 7180 SGTC_762 1165-0429 115 µM -0.482844791846146 0.323387798172611 no 2305 0.314602972071034 3343 5967793 SGTC_963 1269-2853 151 µM -0.483376963457818 0.323185992253473 no 2306 0.314414050981279 3241 3668223 SGTC_1602 st001878 87.6 µM -0.483525514531411 0.32312966917295 no 2307 0.314361323976715 3375 595405 YLR310C CDC25 SGTC_2324 6149169 200 µM -0.483979362241143 0.322957618115658 no 2308 0.314200257858947 3256 2888231 SGTC_1274 0865-0114 173 µM -0.484603242771604 0.322721170421509 no 2309 0.313978906496576 3289 870624 SGTC_1321 1326-2144 215 µM -0.484716574952488 0.322678225763138 no 2310 0.31393870368178 3325 3513030 SGTC_3175 9106517 49.47 µM -0.484958070958005 0.322586724221412 no 2311 0.313853044126309 3336 41468073 SGTC_2394 5221648 200 µM -0.485897192112274 0.322230998418244 no 2312 0.31352002965659 3353 788586 SGTC_2537 larixol 68.93 µM -0.486627275822479 0.321954565465345 no 2313 0.313261245286033 3358 6708759 SGTC_2868 9035608 32.47 µM -0.48809543765371 0.321398970915937 no 2314 0.312741121260046 3276 6462614 SGTC_1657 st012939 43.4 µM -0.488329301545593 0.321310506954245 no 2315 0.312658304944167 3377 24207257 SGTC_1481 3346-2004 36 µM -0.48871886972269 0.321163167062815 no 2316 0.312520371337493 3352 2770522 SGTC_209 4077-0173 175.592 µM -0.489246067352632 0.32096381869542 no 2317 0.312333749367796 3294 15993494 SGTC_3225 9130819 49.47 µM -0.489495266546736 0.320869607371987 no 2318 0.312245552434461 3363 4547121 SGTC_79 0052-0007 94.094 µM -0.490539281537946 0.320475036368052 no 2319 0.311876170154957 3404 2801472 SGTC_2686 alizarin 95.37 µM -0.491530282969408 0.320100688717904 no 2320 0.311525719526636 3273 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1 SGTC_3098 9119039 49.47 µM -0.492517585436558 0.319727920367861 no 2321 0.311176746684273 3357 17161528 SGTC_552 k242-0005 476 µM -0.496150294402416 0.318357915097292 no 2322 0.309894188492459 3379 4088318 SGTC_940 3232-1287 54.8 µM -0.498630749060923 0.317423883737396 no 2323 0.309019769409485 3383 1585493 YIL048W NEO1 SGTC_1361 1608-0041 5.61 µM -0.498864087563938 0.317336078276657 no 2324 0.308937567611644 3302 X1361 SGTC_2465 5809242 33.21 µM -0.499288903843026 0.31717624597454 no 2325 0.308787935517163 3326 2731748 SGTC_1863 st057641 20.1 µM -0.499865193934969 0.316959477873388 no 2326 0.308585000866706 3367 3921635 SGTC_3157 9099274 49.47 µM -0.499968327489759 0.316920691422205 no 2327 0.308548689606946 3399 17217662 SGTC_2784 7567673 72.73 µM -0.500321724297865 0.316787801266158 no 2328 0.308424279867661 3398 3471247 SGTC_2025 5147754 141 µM -0.50036367164667 0.316772029094186 no 2329 0.308409514191765 3309 315777 YLR208W SEC13 SGTC_1842 st055362 61.2 µM -0.502380374936215 0.316014143505275 no 2330 0.30769999055597 3274 676032 SGTC_2705 st078069 42.8 µM -0.502513159355393 0.315964269636865 no 2331 0.307653299062564 3326 1530061 SGTC_2816 7982706 58.44 µM -0.502660082538943 0.315909089147741 no 2332 0.307601639532048 3347 2981853 SGTC_1773 st048542 73.5835 µM -0.502878061685627 0.315827229462419 no 2333 0.307525003106261 3254 3237138 SGTC_1967 st070177 51.4 µM -0.503191422962125 0.31570956588693 no 2334 0.307414847248612 3420 5729214 SGTC_1369 1866-0067 208 µM -0.505073022440354 0.315003439894345 no 2335 0.306753774304336 3414 3531355 SGTC_2737 bleomycin 30.5 nM -0.505212055546772 0.314951290373117 no 2336 0.306704951912619 3380 16211318 Bleomycin acts by induction of DNA strand breaks. SGTC_1397 3532-0190 20.1 µM -0.507019911710063 0.314273523054919 no 2337 0.306070423761776 3238 5322280 SGTC_2408 sulbentine 18.36 µM -0.507089131755694 0.314247584805196 no 2338 0.306046140195902 3241 67686 An antifungal agent of unknown mechanism. YDL205C HEM3 SGTC_502 l-744,832 89.3 µM -0.507158999776199 0.314221404675454 no 2339 0.306021630173816 3379 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.  SGTC_3047 9092122 49.47 µM -0.508196050947077 0.313832922908897 no 2340 0.305657930028779 3335 17173831 SGTC_2023 5144124 124 µM -0.509958998735324 0.313172992155246 no 2341 0.305040093457708 3262 2830192 SGTC_3275 9138069 49.47 µM -0.510098295426156 0.313120874172912 no 2342 0.304991299671127 3375 17617007 SGTC_44 0929-0055 61.211 µM -0.510704178759822 0.312894225822912 no 2343 0.304779107105058 3258 1379590 SGTC_2364 9055074 200 µM -0.515085734287396 0.311257285770043 no 2344 0.303246555497429 3362 6470630 SGTC_3335 9143315 29.6265 µM -0.515598673449185 0.31106589575424 no 2345 0.303067368505122 3300 4899691 SGTC_3070 9117005 49.47 µM -0.51758754566181 0.310324282785939 no 2346 0.302373036558583 3410 8779016 SGTC_1439 4092-1168 46 µM -0.517672027995587 0.310292797956188 no 2347 0.302343558871319 3361 2886240 SGTC_3156 9099931 49.47 µM -0.518919080633952 0.309828208891963 no 2348 0.301908585664625 3268 18111053 SGTC_1793 st048256 72.231 µM -0.519107768007041 0.309757939894476 no 2349 0.301842795817115 3358 672022 SGTC_2361 9034121 116 µM -0.51925572747621 0.309702843223649 no 2350 0.301791211123051 3310 6496917 SGTC_466 geldanamycin 89.2 µM -0.519823164034732 0.309491582671745 no 2351 0.301593416390015 3298 5288382 HSP90 inhibitor. SGTC_1558 st069300 45.6 µM -0.520047662466738 0.309408017726883 no 2352 0.301515177740008 3375 24208000 SGTC_221 trifluoperazine 10.304 µM -0.520398235940434 0.309277543641054 no 2353 0.301393019675789 3400 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1 SGTC_1896 st058441 89 µM -0.520573277425486 0.309212406873666 no 2354 0.301332034442498 3316 688759 SGTC_3356 9151811 4.48 µM -0.520585208426697 0.309207967305268 no 2355 0.30132787783079 3287 1859254 YPR165W RHO1 SGTC_1928 4'-methoxychalcone 40.3 µM -0.520590486865779 0.309206003188018 no 2356 0.301326038896821 3467 641818 SGTC_422 cantharidin 155 µM -0.520875473911504 0.309099967060587 no 2357 0.301226760919071 3330 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_288 1315-0019 35.1 µM -0.521654517829614 0.308810186635187 no 2358 0.30095544869603 3425 6811474 SGTC_1465 k213-0056 144 µM -0.522331748370026 0.30855837432592 no 2359 0.300719683875567 3267 24048857 YMR208W ERG12 SGTC_3160 9100216 49.47 µM -0.523797448190922 0.308013696515366 no 2360 0.300209714224813 3365 17191039 SGTC_1943 st076331 65.2 µM -0.524139286510198 0.307886724589666 no 2361 0.300090832639903 3432 24208415 SGTC_2233 sulbentine 40.3845 µM -0.524830091688862 0.307630203134439 no 2362 0.299850655387916 3376 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58 SGTC_122 0236-0016 402.397 µM -0.525412418731304 0.307414036644958 no 2363 0.2996482611418 3419 6808838 SGTC_2961 9083290 32.55 µM -0.525640820420295 0.307329269568471 no 2364 0.299568894494253 3396 17741490 SGTC_2731 amoxapine 43.43 µM -0.526275630258367 0.307093725661526 no 2365 0.299348356296199 3403 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine. SGTC_2202 7226349 200 µM -0.527846895856377 0.306511055629563 no 2366 0.298802802569053 3304 844334 SGTC_57 miconazole 162.5 nM -0.528098532110907 0.306417787110693 no 2367 0.298715474801575 3372 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_463 ikarugamyin 104 µM -0.529074000735777 0.306056350010533 no 2368 0.298377058190334 3395 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis. SGTC_919 tnp00227 403.569 nM -0.529378569779431 0.305943537717241 no 2369 0.298271430660202 3338 1269246 A methoxyflavone. YNL221C POP1 SGTC_2011 4012611 177 µM -0.529802320323418 0.305786611249157 no 2370 0.298124498147498 3318 2049887 SGTC_367 0335-0881 7.1 µM -0.532411042580546 0.304821315982107 no 2371 0.29722066937322 3434 23828853 SGTC_2806 7952793 58.44 µM -0.534024526282166 0.304224963629276 no 2372 0.296662282693647 3409 2972490 SGTC_1662 st014054 52 µM -0.534075596767587 0.304206096187625 no 2373 0.296644616312236 3388 2838777 SGTC_3052 9092717 49.47 µM -0.534330985312277 0.304111753458007 no 2374 0.296556279141653 3441 25237534 SGTC_52 0329-0193 875 nM -0.534581970397229 0.304019050109515 no 2375 0.296469476841877 3501 3739292 SGTC_1569 carminic acid 40.6 µM -0.535547440945109 0.303662563335818 no 2376 0.296135680879131 3437 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_3353 9151644 39.2805 µM -0.537021206121022 0.303118755860578 no 2377 0.295626482993791 3434 4909158 SGTC_1570 verbenone 133 µM -0.537299219027803 0.303016220193231 no 2378 0.295530472407677 3461 29025 A natural terpanoid with antifungal properties. SGTC_450 aminopyrene 156 nM -0.539020679810675 0.30238166343502 no 2379 0.294936292697952 3408 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1 SGTC_820 1582-0060 59.9 µM -0.539134736282584 0.302339641536101 no 2380 0.294896944397944 3330 3848840 SGTC_2099 5377090 177.372 µM -0.540746944139023 0.301745935213632 no 2381 0.294341008390801 3397 2243829 SGTC_1216 1165-0504 9.65 µM -0.543021429732393 0.300909233274013 no 2382 0.293557523896326 3457 6304004 SGTC_1421 4029-0249 71.4 µM -0.543119774139817 0.300873079490132 no 2383 0.293523669315873 3489 2894095 SGTC_1101 ebselen 5.29 µM -0.543824820949197 0.300613944613389 no 2384 0.293281013369871 3484 3194 A potent scavenger of hydrogen peroxide and hydroperoxides. SGTC_1720 st037298 9.481 µM -0.545025243755331 0.300172969842311 no 2385 0.292868077943225 3410 597396 SGTC_2059 5238311 157 µM -0.545292268299278 0.300074918280853 no 2386 0.292776260434239 3338 703021 SGTC_296 1222-0039 74.9 µM -0.545631516533525 0.299950367040385 no 2387 0.292659627788047 3382 5984176 SGTC_3226 9131256 49.47 µM -0.546096674785735 0.299779627370778 no 2388 0.292499742704393 3381 17178073 SGTC_2481 5478948 45.16 µM -0.546815933559841 0.299515704961172 no 2389 0.292252597655485 3462 77792 SGTC_1014 4130-3005 69.3 µM -0.549364389026478 0.298581432065631 no 2390 0.291377703756844 3356 743608 SGTC_1349 flufenamic acid 69 µM -0.549592526119327 0.298497860866534 no 2391 0.291299443107791 3392 3371 A non-steroidal anti-inflammatory. SGTC_3018 9082602 49.47 µM -0.549612632005736 0.298490496186818 no 2392 0.291292546410816 3460 17332089 SGTC_145 3737-0113 38.366 µM -0.549927094810872 0.298375320886037 no 2393 0.291184689676213 3484 6849351 SGTC_2732 terfenadine 20 µM -0.552176494916922 0.297552045020458 no 2394 0.290413718398334 3419 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.  SGTC_2815 7968870 71.43 µM -0.552734411515594 0.297348009291827 no 2395 0.290222643129066 3414 2977326 YHR190W ERG9 SGTC_2934 9036370 36.88 µM -0.55392555087117 0.296912611659786 no 2396 0.289814898951717 3407 6462800 SGTC_3244 9134489 49.47 µM -0.554556990883972 0.29668191951872 no 2397 0.289598856978817 3425 16584271 SGTC_188 3229-0966 278.469 µM -0.55480829266826 0.29659013102936 no 2398 0.289512897191876 3483 5722370 SGTC_2098 5376439 882.5 nM -0.555855817846301 0.296207660527557 no 2399 0.289154711953864 3440 2844116 SGTC_187 1488-2104 32.728 µM -0.557268914962616 0.295692071834514 no 2400 0.288671855367739 3435 2852859 SGTC_1024 4507-0395 26 µM -0.558045415804882 0.295408930095658 no 2401 0.288406686086355 3508 4201836 SGTC_1962 st076595 64.5 µM -0.558104710724106 0.295387314039694 no 2402 0.288386442030717 3412 279619 SGTC_217 ketoconazole 989 nM -0.558776760065426 0.29514236827634 no 2403 0.288157042493167 3410 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4 SGTC_1733 st037357 54.9 µM -0.559067945730623 0.295036267178906 no 2404 0.288057674957782 3378 1272339 YGL099W LSG1 SGTC_1910 st062352 60.4 µM -0.5609631689825 0.294346122850532 no 2405 0.287411322746813 3385 2245730 SGTC_34 0469-0683 81.75 µM -0.563638473304854 0.293373183423245 no 2406 0.286500098907476 3438 3690923 SGTC_2979 9012552 45.46 µM -0.566846546137768 0.292208458559906 no 2407 0.285409221840969 3526 17100905 SGTC_1399 3562-5772 25 µM -0.567006545083727 0.29215042561183 no 2408 0.285354867426162 3425 23847490 SGTC_901 1112-0062 60.1 µM -0.567116295265829 0.292110621409684 no 2409 0.285317586238376 3438 1908457 SGTC_1257 0669-0121 16 µM -0.567295713308086 0.292045555500479 no 2410 0.285256644478328 3446 4307855 SGTC_2306 7482397 179.52 µM -0.568274519418231 0.291690710561228 no 2411 0.284924289023053 3496 891448 SGTC_1806 st050005 60.3 µM -0.568690523320196 0.291539958241155 no 2412 0.284783090069589 3400 5194765 SGTC_86 0417-1630 471.922 µM -0.569689304909258 0.291178166198572 no 2413 0.284444222634248 3486 3634867 SGTC_3008 9078912 71.4286 µM -0.569714058236946 0.291169202379455 no 2414 0.284435826751843 3452 16648731 SGTC_3014 9081533 49.47 µM -0.569931117485096 0.29109060514032 no 2415 0.284362209240457 3489 21367265 SGTC_1082 camptothecin 424.86 nM -0.570906156115592 0.290737665561387 no 2416 0.28403162886584 3328 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_2472 5377652 49.4 µM -0.571488993294931 0.290526788698006 no 2417 0.283834109627442 3444 1610903 SGTC_1393 3470-5649 58.2 µM -0.572592710400492 0.290127648019933 no 2418 0.283460248274885 3405 4108395 SGTC_2736 butenafine 14.65 µM -0.572634804006527 0.290112430665619 no 2419 0.28344599460994 3421 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_1196 1588-0294 184 µM -0.574155889106739 0.289562790913275 no 2420 0.282931158029266 3446 6144269 SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM -0.575905653580932 0.288931123919988 no 2421 0.282339477016962 3437 4620898 SGTC_3124 9127567 49.47 µM -0.577633265699646 0.288308090819504 no 2422 0.281755871462114 3484 17592030 SGTC_1870 st057514 26.5 µM -0.578096944062248 0.288140981224159 no 2423 0.281599335065537 3423 5393161 SGTC_700 3453-2283 142 µM -0.578726235609633 0.287914257796655 no 2424 0.281386955276243 3539 565664 SGTC_1232 0279-0259 161 µM -0.579945847321354 0.287475091684701 no 2425 0.28097556838245 3454 1560000 SGTC_2020 4017018 200 µM -0.580161904056684 0.28739732554269 no 2426 0.280902720661142 3477 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope. SGTC_538 2922-0838 53.3 µM -0.581145166191612 0.287043541923036 no 2427 0.28057131011448 3533 777039 SGTC_1590 st077108 57.8 µM -0.581305811162732 0.286985760504969 no 2428 0.280517182379629 3489 5489485 SGTC_1121 fusaric acid 630.51 nM -0.582052899870838 0.286717117102397 no 2429 0.280265524650726 3404 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler. SGTC_2013 4024628 200 µM -0.582991732417407 0.286379694255178 no 2430 0.279949432922781 3519 5230760 SGTC_2707 st078556 66.6 µM -0.583008803572838 0.286373560510182 no 2431 0.279943686905127 3442 17250899 SGTC_489 paxilline 115 µM -0.583505282062418 0.286195200780194 no 2432 0.279776601142467 3472 105008 A toxic potassium channel blocker. SGTC_2561 acetosyringone 100 µM -0.586232988616478 0.285216215547271 no 2433 0.278859477996824 3399 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent. SGTC_2889 9059656 51.95 µM -0.587566857597235 0.284738066085868 no 2434 0.278411531112032 3496 3949838 SGTC_577 r071-0003 38.6 µM -0.587689027041387 0.284694291371204 no 2435 0.278370521063012 3493 4568517 YMR134W ERG29 SGTC_2680 butyl paraben 22.24 µM -0.588906029135562 0.284258401032941 no 2436 0.277962156525652 3517 7184 An antifungal and steroid mimetic. SGTC_46 0329-0187a 2.197 µM -0.590672492696043 0.283626279775707 no 2437 0.277369941057962 3471 46494817 SGTC_845 0330-0138 4.51 µM -0.590675194175175 0.283625313579143 no 2438 0.277369035846658 3466 9039800 SGTC_126 0417-1624 672.48 µM -0.590858907461599 0.283559611368581 no 2439 0.277307480610042 3593 41912 YDL195W SEC31 SGTC_846 0335-0850 148 µM -0.591500119181184 0.28333034909697 no 2440 0.277092687659087 3493 6819598 SGTC_2769 toremifene 3.73 µM -0.591786681538205 0.283227918803481 no 2441 0.276996721399075 3551 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_719 2810-4230 27.3 µM -0.592362568830742 0.283022124481529 no 2442 0.276803912941983 3474 721079 SGTC_2990 9074105 71.4286 µM -0.592427156082965 0.282999048592162 no 2443 0.2767822930744 3485 6502001 SGTC_881 0833-0569 170 µM -0.595578481313633 0.281874234071038 no 2444 0.27572842782275 3419 5418700 SGTC_1326 1431-2094 10.8 µM -0.596023800280126 0.281715458554341 no 2445 0.275579663583511 3465 616278 SGTC_1054 3429-0080 167 µM -0.596499541614898 0.281545883793809 no 2446 0.275420779998743 3539 1162877 SGTC_1680 diphenhydramine 100 µM -0.598099227965353 0.280976047879014 no 2447 0.274886862687708 3433 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1 SGTC_1188 1403-0014 4.57 µM -0.598275875776128 0.280913157064633 no 2448 0.274827935341018 3502 9614867 SGTC_1476 4112-3294 3.34 µM -0.598908192631277 0.280688093038152 no 2449 0.274617053946109 3545 704369 SGTC_2536 dehydroabietamide 32.04 µM -0.599918989069839 0.280328495947556 no 2450 0.274280113241151 3540 3983547 SGTC_873 0591-4978 488 µM -0.602315472618307 0.279476824695293 no 2451 0.273482081713409 3605 3305145 SGTC_171 k064-0041 9.68 µM -0.602480893433456 0.279418083222328 no 2452 0.273427038845255 3439 53325 SGTC_2131 toluylene red 5.2905 µM -0.604283219240717 0.278778460339382 no 2453 0.272827680503395 3472 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain. SGTC_2415 st077333 57.7 µM -0.604509120439854 0.278698341117118 no 2454 0.272752603685188 3601 2766255 SGTC_2676 harmalol 100 µM -0.605718507337002 0.278269604813018 no 2455 0.272350846102778 3549 5459187 A monoamine oxidase inhibitor SGTC_2183 6420625 130.508 µM -0.606487326189542 0.27799722031339 no 2456 0.272095597889342 3569 2897619 SGTC_333 3486-0131 40.1 µM -0.606787105224028 0.277891046994575 no 2457 0.271996103350143 3602 6744690 SGTC_776 4476-4378 112 µM -0.607085347708829 0.277785437523829 no 2458 0.271897136738614 3522 2892008 SGTC_1629 st005085 44.9 µM -0.608475193082779 0.277293543481494 no 2459 0.271436176971704 3496 24207091 SGTC_335 4077-0256 27.6 µM -0.608556798743405 0.277264674853648 no 2460 0.271409123529841 3537 3121989 SGTC_983 1491-0821 12.2 µM -0.609122830347372 0.27706447730493 no 2461 0.27122151295341 3522 46495113 SGTC_523 1934-0222 13.7 µM -0.609292967136771 0.277004316107247 no 2462 0.271165133934107 3522 1361595 SGTC_2492 derrusnin 100 µM -0.61018280252723 0.27668977020108 no 2463 0.2708703602784 3490 1715307 Part of coumarin class of compounds. SGTC_695 3505-6186 243 µM -0.610306775031163 0.276645961334568 no 2464 0.270829304897299 3535 1819379 SGTC_2334 9017922 200 µM -0.610531296116404 0.276566629699909 no 2465 0.270754959230533 3514 3163164 SGTC_3037 9091026 49.47 µM -0.610771934374975 0.276481615652734 no 2466 0.270675287998158 3552 25236398 YIL048W NEO1 SGTC_3 0833-0587 95.581 µM -0.611852938853448 0.276099870415244 no 2467 0.270317530295427 3494 5382644 SGTC_1834 st055981 52.8 µM -0.614161987229415 0.275285322226944 no 2468 0.269554144896748 3589 471719 YDL150W RPC53 SGTC_969 1313-0238 134 µM -0.616200063157373 0.274567347370139 no 2469 0.268881243381813 3506 5212874 SGTC_2424 5537928 59.2 µM -0.617409674265275 0.274141661975974 no 2470 0.268482271279873 3537 5382802 SGTC_1958 st076513 41.9 µM -0.618538396333635 0.273744737259769 no 2471 0.268110247848959 3473 732122 YGL099W LSG1 SGTC_555 4296-0685 37 µM -0.618693728393527 0.273690135678541 no 2472 0.268059071182386 3517 2908540 YHR072W ERG7 SGTC_1948 st076329 66.6 µM -0.621377606545341 0.27274756334482 no 2473 0.267175601243052 3474 24208413 SGTC_1435 4092-0789 56.7 µM -0.62280463530797 0.272247050547681 no 2474 0.266706455953312 3566 2248285 SGTC_2768 sulfasalazine 50.2 µM -0.623733873254386 0.271921377314771 no 2475 0.266401186756169 3604 5384001 An antioxidant and salicylic acid derivative. SGTC_2343 7990716 14.84 µM -0.62454577248839 0.271636986907471 no 2476 0.266134609944177 3528 6456862 SGTC_2069 5228469 200 µM -0.625382280460163 0.271344131570861 no 2477 0.265860094511029 3524 2835210 SGTC_3015 9080845 49.47 µM -0.625613612204356 0.271263171796447 no 2478 0.265784204093335 3571 5296973 SGTC_2585 alliin 100 µM -0.626369051123622 0.270998872756128 no 2479 0.265536452201554 3645 87310 A garlic compound which reacts with lipids. SGTC_636 0kpi-0074 126 µM -0.626898336800647 0.270813772608337 no 2480 0.265362938792021 3529 616434 SGTC_2251 lansoprazole 556 µM -0.628012333841215 0.270424395317944 no 2481 0.264997930124316 3445 3883 Gastric proton pump inhibitor. YBR192W RIM2 SGTC_633 0437-0093 97.7 µM -0.628185986381568 0.270363723464605 no 2482 0.264941054685266 3562 2831118 SGTC_1701 st028638 40.4 µM -0.628586092038011 0.270223957853474 no 2483 0.264810033948191 3552 3490878 SGTC_2449 5812982 45.77 µM -0.628814154450356 0.270144306861001 no 2484 0.264735366153327 3551 776185 SGTC_219 mitoxanthrone 164.414 µM -0.629104633814064 0.270042873701979 no 2485 0.264640278508677 3521 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA.  YMR168C CEP3 SGTC_269 exalamide 29 µM -0.631349449913443 0.269259644425885 no 2486 0.263906030278823 3524 3316 A derivative of salicylamide. SGTC_1576 erythromycin ethylsuccinate 23.2 µM -0.631434363825616 0.269230039852058 no 2487 0.263878276512846 3575 3256 An antibiotic and ribosome inhibitor. SGTC_2474 5321570 43.32 µM -0.632958893447143 0.268698802433831 no 2488 0.263380243524449 3551 2841384 SGTC_2681 menadione 3.18 µM -0.633047647904897 0.268667891295861 no 2489 0.263351264028272 3585 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_2755 lomerizine 42.69 µM -0.633505445889837 0.268508479160728 no 2490 0.263201812834714 3563 3949 A calcium channel blocker. SGTC_2950 9072895 21.46 µM -0.633881352079385 0.268377618540036 no 2491 0.263079128163161 3539 17332245 SGTC_1078 idebenone 36.1 µM -0.634140023573766 0.268287588343795 no 2492 0.262994722408356 3572 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen. SGTC_680 0417-1641 114 µM -0.635087312983708 0.267958015543779 no 2493 0.262685735519813 3532 2835990 SGTC_2299 7976368 114.88 µM -0.635846735871314 0.267693950963304 no 2494 0.262438161138031 3562 2979718 SGTC_1149 3909-7961 23.3 µM -0.637467266394244 0.267130903101211 no 2495 0.261910262553194 3539 735261 SGTC_1316 1272-0050 65.9 µM -0.639077929013615 0.266571876830342 no 2496 0.26138611858954 3594 7340392 SGTC_2281 7943571 200 µM -0.639307358455102 0.266492294980414 no 2497 0.26131150121481 3636 1244024 SGTC_2261 9010538 184.68 µM -0.639419177489232 0.266453512834128 no 2498 0.261275138258592 3535 6457250 SGTC_851 0394-0702 453 µM -0.640066958131589 0.266228899552147 no 2499 0.26106453459738 3594 762646 SGTC_1088 bifonazole 369 nM -0.64275594039019 0.265297540153339 no 2500 0.260191238191086 3545 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase. SGTC_2444 5485484 36.41 µM -0.64535206692469 0.264399914340984 no 2501 0.259349529197334 3627 6790631 SGTC_2725 haloperidol 53.21 µM -0.645685329598903 0.264284798898382 no 2502 0.259241581669068 3552 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_191 3914-0123 66.505 µM -0.647328112247908 0.263717722851877 no 2503 0.258709805454555 3484 3144412 SGTC_3077 9117319 49.47 µM -0.648034585438744 0.263474044666963 no 2504 0.258481290616534 3597 17154678 SGTC_3022 9087993 49.47 µM -0.64837835660414 0.263355511991646 no 2505 0.258370132699244 3609 17173644 SGTC_1177 0983-0204 23.6 µM -0.649688265618116 0.262904103600345 no 2506 0.257946802594251 3624 766818 SGTC_3036 9090181 49.47 µM -0.650443692795575 0.262643955443736 no 2507 0.257702830963381 3609 25236586 SGTC_2947 9072639 7.68 µM -0.651651121394501 0.262228424225451 no 2508 0.257313130531295 3608 16488146 SGTC_326 k292-0812 17.5 µM -0.652381916377617 0.261977088074453 no 2509 0.257077413599609 3564 3579357 SGTC_1431 4049-0260 9.09 µM -0.654598238697846 0.261215603021138 no 2510 0.256363229195919 3592 3854841 SGTC_2097 5376186 200 µM -0.655246614178857 0.260993049097538 no 2511 0.256154493312103 3580 742755 SGTC_1408 3909-7976 48.8 µM -0.657554603684527 0.260201627090211 no 2512 0.255412186581394 3632 24152374 SGTC_2811 7967822 32.47 µM -0.657555199137369 0.260201423065939 no 2513 0.255411995214128 3602 2232244 SGTC_792 4534-1957 155 µM -0.657810316655157 0.260114017908977 no 2514 0.25533001216948 3580 1717904 SGTC_742 0kpi-0133 140 µM -0.657850082291636 0.260100395270097 no 2515 0.255317234560823 3617 2728852 SGTC_2704 st078022 71.1 µM -0.659853960000328 0.259414397167478 no 2516 0.254673775879322 3638 54697681 SGTC_2232 chlorophetanol 41.5365 µM -0.660742611998825 0.259110479619408 no 2517 0.254388695765726 3665 15907 An antifungal of unknown mechanism. YFR051C RET2 SGTC_1130 3454-2858 15.9 µM -0.661792830652452 0.258751544019549 no 2518 0.254052000722534 3576 715628 YIL048W NEO1 SGTC_2388 9080168 200 µM -0.663223659194102 0.258262940986512 no 2519 0.253593660484161 3575 15943073 SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM -0.665220023183684 0.257582017386757 no 2520 0.252954887677134 3589 5711223 A potent inhibitor of glutathione S-transferases. SGTC_2565 isoliquiritigenin 100 µM -0.665333670731616 0.25754328233418 no 2521 0.252918549576342 3568 638278 Binds to benzodiazepine receptor 65X better than valium. SGTC_61 0978-8327 98.565 µM -0.665380661343652 0.257527267176949 no 2522 0.25290352542155 3639 6150059 YHR072W ERG7 SGTC_3090 9117696 49.47 µM -0.665764209562566 0.257396567112621 no 2523 0.252780912369697 3587 7923821 SGTC_220 paclitaxel 373.376 µM -0.666016316700307 0.257310676432921 no 2524 0.252700335575813 3595 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_800 3448-7362 155 µM -0.666207169775565 0.257245664380626 no 2525 0.252639345391932 3698 15991913 SGTC_1762 st045503 25.4615 µM -0.669137221067175 0.25624864670278 no 2526 0.2517039742481 3635 4645554 SGTC_1693 xanthone 101.9 µM -0.673864615118971 0.254644298955574 no 2527 0.250198695156013 3665 7020 An insecticide. SGTC_2284 7945075 39.21 µM -0.674490759476595 0.254432197977174 no 2528 0.249999679274407 3695 1245402 SGTC_286 k060-0067 22.9 µM -0.676303909326642 0.253818531763808 no 2529 0.249423855611483 3612 5985051 SGTC_3003 9075612 71.4286 µM -0.676706020664415 0.253682541272893 no 2530 0.249296247876352 3633 6501993 SGTC_2654 protoveratrine a 100 µM -0.677454214653449 0.25342961056673 no 2531 0.249058905197471 3612 5702278 A heart drug and vasodilator. SGTC_3306 9127676 59.7925 µM -0.677921810775755 0.253271604689911 no 2532 0.248910635057896 3641 41905287 SGTC_275 trichlorophene 5.69 µM -0.678438106994714 0.253097202700853 no 2533 0.248746977186134 3674 62616 SGTC_1667 st014849 34.6 µM -0.679066098967 0.252885155690256 no 2534 0.248547990755887 3683 5348460 SGTC_828 2074-0507 139 µM -0.679555143867135 0.252720090166746 no 2535 0.248393090049634 3682 X828 SGTC_162 k030-0015 37.8 µM -0.679708740660315 0.25266825891768 no 2536 0.24834445022557 3698 1809920 YMR134W ERG29 SGTC_445 e6 berbamine 66 µM -0.68040143220123 0.252434579682764 no 2537 0.248125157213775 3689 6610268 A calcium/calmodulin antagonist. SGTC_228 caffeine 993.056 µM -0.681119508748257 0.252192457114887 no 2538 0.247897936870703 3645 2519 Caffeine is a phosphodiesterase inhibitor. SGTC_2215 7188065 200 µM -0.681987202786798 0.251900049697438 no 2539 0.247623521441271 3652 940217 SGTC_767 0929-0023 86 µM -0.682358032971189 0.251775136867773 no 2540 0.247506292831591 3712 1204563 SGTC_215 1287-0124 461.5 µM -0.682601467702039 0.251693154529292 no 2541 0.247429353206739 3650 5560863 SGTC_1723 st034307 2.5525 µM -0.682986515384276 0.251563509508933 no 2542 0.247307681702786 3675 867466 SGTC_3290 9121031 71.43 µM -0.68559914820164 0.25068477232465 no 2543 0.24648295941409 3628 17014854 SGTC_2163 5671233 125 µM -0.685783421475957 0.250622854983493 no 2544 0.246424846085847 3694 701023 SGTC_1089 terbinafine 2.25 µM -0.68581447522142 0.250612421466373 no 2545 0.246415053546586 3639 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_1651 st011928 86.1 µM -0.685840818468775 0.250603570774883 no 2546 0.246406746587056 3651 720198 SGTC_351 caspofungin 25 nM -0.68584285977078 0.250602884953886 no 2547 0.246406102898453 3698 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1 SGTC_2912 7964298 10.93 µM -0.68658423553938 0.250353868975172 no 2548 0.24617238272845 3686 2975850 SGTC_656 4090-1979 187 µM -0.686614310544313 0.250343770042775 no 2549 0.246162904033799 3670 22330961 SGTC_604 1000-0114 314 µM -0.687066248725657 0.250192039031651 no 2550 0.246020490920718 3681 1572745 SGTC_180 1486-1293 102.781 µM -0.687332319819338 0.250102732735022 no 2551 0.245936668243704 3679 4140536 SGTC_2405 ticlatone 3.52 µM -0.6873929540784 0.250082383318381 no 2552 0.245917568253279 3574 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W SGTC_530 4358-1714 28 µM -0.690349034990383 0.249091361493521 no 2553 0.244987359240581 3699 1564641 SGTC_134 0269-0018 6.916 µM -0.691197002757344 0.248807467621675 no 2554 0.244720873591183 3590 4378915 SGTC_1746 st038117 42 µM -0.691626144611501 0.248663859508208 no 2555 0.244586069303284 3676 2898218 SGTC_2417 cerulenin 830 nM -0.692776731793513 0.248279044749538 no 2556 0.244224838280253 3719 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1 SGTC_3334 9142812 21.919 µM -0.692891835873541 0.248240565580611 no 2557 0.244188716769383 3685 45283678 SGTC_1247 0448-0043 5.84 µM -0.69308637320535 0.248175539191552 no 2558 0.244127674375869 3708 3089013 YGL099W LSG1 SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM -0.697704251993112 0.246634629822214 no 2559 0.242681084248998 3676 688761 SGTC_2134 5324836 1.464 µM -0.697906201020581 0.246567359933859 no 2560 0.242617928067804 3644 699272 SGTC_2242 6630449 61.2675 µM -0.697991121992096 0.246539075413471 no 2561 0.242591373112341 3686 691249 YDR170C SEC7 SGTC_1727 st034309 9.9045 µM -0.69970867256851 0.245967386308347 no 2562 0.242054629634327 3707 870305 SGTC_2849 9019321 12.99 µM -0.70024464387083 0.245789133241827 no 2563 0.241887267753528 3649 16489627 SGTC_2114 5491910 81.25 µM -0.700753852580396 0.24561984512694 no 2564 0.241728320909211 3722 2849228 SGTC_2148 5546263 113.568 µM -0.701783471040287 0.245277736489207 no 2565 0.241407104148698 3682 792097 SGTC_2832 7992762 51.95 µM -0.702278205103327 0.245113443653591 no 2566 0.241252841264914 3614 2985177 SGTC_2781 5567276 71.43 µM -0.702749978377598 0.244956830854987 no 2567 0.241105787692789 3688 2853274 SGTC_957 1187-1561 14.1 µM -0.703444687189348 0.244726309035995 no 2568 0.240889332988213 3664 1538454 SGTC_1347 1493-0251 600 nM -0.703669597138181 0.244651703305443 no 2569 0.240819279068001 3710 3986378 SGTC_216 k038-0035 28.382 µM -0.70370881109997 0.244638696747713 no 2570 0.240807066017781 3608 4444231 YPR107C YTH1 SGTC_2679 rapamycin 1 nM -0.707241622488574 0.243468456858646 no 2571 0.239708168362076 3679 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2 SGTC_2179 6298986 200 µM -0.707289051548819 0.243452766633809 no 2572 0.239693433968435 3638 738374 SGTC_2068 5226020 147 µM -0.708108539185264 0.243181754453263 no 2573 0.239438928589337 3734 1810509 SGTC_1883 5-benzylidenerhodanine 20 µM -0.709900902718254 0.242589572114473 no 2574 0.238882795302297 3683 1273210 SGTC_260 nsc-65238 3.989 µM -0.710126712008809 0.2425150219872 no 2575 0.238812781495795 3629 3246252 SGTC_981 1488-1094 54.9 µM -0.711787284455724 0.241967171294644 no 2576 0.238298253919154 3669 3449522 SGTC_1245 0418-0076 17.2 µM -0.713577637857404 0.241377256549382 no 2577 0.237744194704713 3704 6790114 SGTC_1359 1582-0056 520 nM -0.713595057895942 0.241371520552652 no 2578 0.237738807213026 3751 3661189 SGTC_2702 st077768 96.8 µM -0.714127315001776 0.241196296884129 no 2579 0.237574228456536 3631 6484119 SGTC_37 0566-0070 1.56 µM -0.714263406986201 0.241151505321066 no 2580 0.237532157611966 3714 1626686 SGTC_1880 MG-132 525 µM -0.715371816063815 0.24078686627438 no 2581 0.237189661489736 3647 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1 SGTC_1586 deoxycorticosterone acetate 53.7 µM -0.716689618857876 0.240353732572991 no 2582 0.23678281639268 3666 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE. SGTC_1902 st060212 70.5 µM -0.717240768678093 0.240172707329206 no 2583 0.236612773860624 3719 688944 SGTC_1532 4',5'-dihydroxyflavone 78.7 µM -0.717889074992062 0.239959866168361 no 2584 0.23641284231398 3721 165521 SGTC_1482 3346-2049 8.48 µM -0.718521158424944 0.239752450106637 no 2585 0.236218003316536 3719 3826804 SGTC_707 0865-0008 204 µM -0.719966804101709 0.239278434262568 no 2586 0.235772717300509 3697 723043 SGTC_3031 9088762 49.47 µM -0.720886706756281 0.238977072183075 no 2587 0.23548961114105 3688 205253 SGTC_1816 st051957 91.6 µM -0.721179991256395 0.238881035199905 no 2588 0.235399390336648 3702 674121 SGTC_781 4335-2806 94.4 µM -0.721711448572481 0.238707061528711 no 2589 0.235235950919571 3827 845254 SGTC_3044 9093193 49.47 µM -0.723333069227252 0.238176649334316 no 2590 0.234737640338471 3700 25236277 SGTC_966 1300-0360 30.2 µM -0.723568687229959 0.23809963534718 no 2591 0.23466528547009 3710 70588 SGTC_3337 9144342 33.5465 µM -0.725262102947652 0.237546528014452 no 2592 0.234145625091246 3731 17682949 SGTC_2974 9094440 9.66 µM -0.725657435700494 0.23741750512573 no 2593 0.234024400694364 3796 25236134 SGTC_415 dibenzyl ketone 100 µM -0.726535423402632 0.237131098070676 no 2594 0.233755299895611 3734 7593 SGTC_831 k061-1017 217 µM -0.727007597434222 0.23697714941697 no 2595 0.233610650814795 3773 1240153 SGTC_2280 7785178 200 µM -0.72716765760761 0.236924975518191 no 2596 0.233561628132968 3724 2954328 SGTC_1029 k015-0030 64.7 µM -0.727972079306469 0.236662858419757 no 2597 0.233315339013035 3790 2208316 SGTC_2571 chrysanthemic acid 100 µM -0.728647234661101 0.236442985351689 no 2598 0.233108738549762 3718 2743 An insecticide. SGTC_1761 st044296 37 µM -0.731853456251785 0.235400374204172 no 2599 0.232129008639765 3733 1826700 SGTC_526 4469-0568 170 µM -0.733250419217012 0.23494689942436 no 2600 0.231702854501787 3724 2901964 SGTC_2271 7849410 118.62 µM -0.73334306643438 0.234916841849266 no 2601 0.231674607189053 3693 972430 SGTC_1581 himbacine 57.9 µM -0.733467951791193 0.234876328604266 no 2602 0.231636533791281 3737 5281825 An alkaloid muscarinic receptor antagonist. SGTC_505 gw-5074 63.9 µM -0.734785122743763 0.234449268976104 no 2603 0.231235184521584 3771 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases. SGTC_143 4032-1194 15.74 µM -0.734836806609055 0.234432520543929 no 2604 0.231219444076194 3750 1806963 SGTC_2401 5128683 200 µM -0.73509479878963 0.234348926702906 no 2605 0.231140880877753 3700 708373 SGTC_328 k915-0120 63.5 µM -0.735884054920368 0.234093296790612 no 2606 0.230900630888869 3735 6624543 SGTC_509 pifithrin 175 µM -0.737589058315311 0.23354159560458 no 2607 0.230382103206607 3766 4817 A p53 inhibitor. SGTC_3085 9117376 49.47 µM -0.737591759114788 0.233540722258326 no 2608 0.230381282353009 3822 16480349 SGTC_2404 5161160 200 µM -0.738010156149204 0.233405448832222 no 2609 0.230254138752324 3696 2831543 SGTC_842 0271-0008 11.1 µM -0.740460776047859 0.232614003811958 no 2610 0.229510226485062 3795 1221709 SGTC_1787 fluconazole 80 µM -0.740515329704478 0.232596402314695 no 2611 0.229493681468689 3633 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C SGTC_3181 9108277 49.47 µM -0.74064398699958 0.232554894536932 no 2612 0.229454664970255 3696 17097298 SGTC_1781 st038725 66.3 µM -0.743364092069266 0.231678291230794 no 2613 0.228630638941255 3761 4270275 YIL048W NEO1 SGTC_2151 5563267 85.4165 µM -0.74388796484117 0.231509675420428 no 2614 0.228472128497917 3777 5310824 SGTC_2724 maprotiline 69.64 µM -0.745014806852134 0.231147217444485 no 2615 0.228131384372934 3702 4011 A tricyclic antidepressant. SGTC_144 4161-2749 112.381 µM -0.74599141607862 0.230833339389418 no 2616 0.227836300212966 3671 797501 YMR168C CEP3 SGTC_1679 SEC14.276 6.7 µM -0.746171243222876 0.230775569669973 no 2617 0.227781988556555 3792 1005053 YMR079W SEC14 SGTC_706 4262-0057 46.9 µM -0.746884976629825 0.230546361471145 no 2618 0.227566497617839 3737 883298 SGTC_1879 gemcitabine 100 µM -0.747379469321189 0.230387634827343 no 2619 0.227417267347113 3749 60750 A nucleoside analog which inhibits DNA replication. SGTC_2010 4012422 159 µM -0.74788389648735 0.230225782298289 no 2620 0.227265095819386 3748 952393 SGTC_2615 purpurogallin-4-carboxylic acid 100 µM -0.748921022409605 0.229893205793541 no 2621 0.226952404358422 3760 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase. SGTC_1353 1498-1206 8.11 µM -0.750650892156103 0.229339085099689 no 2622 0.226431392232945 3799 6756808 SGTC_1695 st026914 34.495 µM -0.750784630664804 0.229296276501448 no 2623 0.226391140246567 3714 3289191 SGTC_1717 st033143 58.0435 µM -0.751695782871363 0.229004743424361 no 2624 0.226117013524915 3742 674616 SGTC_3139 9095020 49.47 µM -0.752475369854986 0.228755471249894 no 2625 0.225882618139673 3536 25236292 SGTC_1031 k035-0009 16 µM -0.753637589694357 0.228384135579434 no 2626 0.225533433260534 3810 5180959 SGTC_643 k048-0106 28.4 µM -0.754380218216444 0.228147039136181 no 2627 0.225310473191528 3781 6763920 SGTC_1329 1447-1697 50.6 µM -0.754919412371104 0.227974979239368 no 2628 0.225148668660438 3789 2840515 SGTC_3120 9124077 49.47 µM -0.75585450269538 0.22767675977286 no 2629 0.224868217427712 3809 18774327 YGL155W CDC43 SGTC_292 k038-0015 474 µM -0.755912294271251 0.227658336063504 no 2630 0.224850891144151 3747 46368540 SGTC_2890 9046729 58.44 µM -0.757310897915348 0.227212723170229 no 2631 0.224431811702956 3705 903329 SGTC_1835 st008666 49.2 µM -0.757537302690652 0.227140633990257 no 2632 0.224364013189419 3707 690455 SGTC_888 0916-0002 6.97 µM -0.758153716046441 0.226944428157855 no 2633 0.224179482770397 3853 2802138 YIL048W NEO1 SGTC_2677 mitomycin C 100 µM -0.758425785209222 0.226857858312796 no 2634 0.224098063164603 3771 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_190 3970-0790 3.722 µM -0.758506856342534 0.226832065844656 no 2635 0.224073805009709 3711 2832352 SGTC_980 1473-0395 201 µM -0.758725360734511 0.22676255775439 no 2636 0.224008431417975 3690 768876 SGTC_2018 5133068 143 µM -0.759122691559847 0.226636194268445 no 2637 0.223889583120093 3763 785362 SGTC_81 0411-0046 9.971 µM -0.75924168891041 0.226598357167517 no 2638 0.223853995995765 3686 12925265 SGTC_2380 9035439 200 µM -0.759970919403957 0.226366564623888 no 2639 0.223635983921345 3877 6462575 SGTC_3269 9137823 49.47 µM -0.760439223142679 0.226217780663663 no 2640 0.223496042671929 3713 17682936 SGTC_3104 9120930 49.47 µM -0.761319542686009 0.225938245494088 no 2641 0.223233115338695 3796 17014836 SGTC_3342 9147791 14.508 µM -0.761325817096251 0.225936253829746 no 2642 0.223231241976371 3718 1838168 SGTC_2809 7964133 12.99 µM -0.765468575396012 0.224623401231822 no 2643 0.221996285965414 3818 1253665 SGTC_2231 micatex 6.853 µM -0.766329818215478 0.224351015126094 no 2644 0.221740040163092 3804 20737 An antifungal of unknown mechanism. SGTC_88 0180-0332 8.668 µM -0.768157549433495 0.223773578401642 no 2645 0.221196795019547 3850 3101745 SGTC_1170 0310-0127 64.8 µM -0.768224614167428 0.223752406662437 no 2646 0.221176876278919 3801 774975 SGTC_2377 9073351 62.6 µM -0.770071483355608 0.223169814155776 no 2647 0.220628745337805 3770 7337946 YHR072W ERG7 SGTC_313 3474-0040 5.03 µM -0.771847627951661 0.222610347147893 no 2648 0.220102339519908 3764 1043375 YIL048W NEO1 SGTC_948 3448-0295 75.3 µM -0.771925890490103 0.222585713671031 no 2649 0.220079161001144 3790 678569 SGTC_3039 9090270 49.47 µM -0.772129524421183 0.222521626282018 no 2650 0.220018858595233 3766 17173750 SGTC_3169 9102970 49.47 µM -0.772406865065499 0.222434358944067 no 2651 0.219936744564765 3855 17027839 SGTC_754 3474-0146 171 µM -0.772714215250512 0.222337671682 no 2652 0.219845765962728 3753 24762078 SGTC_1204 4049-0315 18.3 µM -0.772731283018317 0.222332303148572 no 2653 0.219840714372934 3881 588402 SGTC_2982 9019404 25.97 µM -0.773025284274228 0.222239838952216 no 2654 0.21975370854677 3728 22333232 SGTC_2722 naftopidil 47.16 µM -0.773422574192189 0.222114925056716 no 2655 0.219636167203667 3730 4418 An a1-adrenergic receptor antagonist or alpha blocker.  SGTC_2710 st078562 53.7235 µM -0.773595485331525 0.222060571725791 no 2656 0.219585021362944 3765 17250908 SGTC_3045 9092950 49.47 µM -0.776019164811933 0.221299505640435 no 2657 0.218868835094653 3763 44120432 SGTC_3062 9077494 49.47 µM -0.776664359887759 0.2210971579144 no 2658 0.218678409620138 3784 16459633 SGTC_544 k015-0020 52.4 µM -0.77891857477827 0.220391016986705 no 2659 0.218013840675263 3809 3008304 SGTC_1510 1123-0200 71.5 µM -0.7793363143333 0.220260300690519 no 2660 0.217890814167705 3831 5378812 YNL149C | YNL150W PGA2 | YNL150W SGTC_358 0075-0058 9.45 µM -0.77951885611005 0.220203194885855 no 2661 0.217837067221722 3736 1069125 SGTC_258 haloperidol 50.781 µM -0.779758756007704 0.220128158257011 no 2662 0.217766443585784 3825 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_1205 4161-2785 76 µM -0.780176002336942 0.219997685607178 no 2663 0.217643642768309 3895 3498106 SGTC_3251 9135047 49.47 µM -0.780566748660173 0.219875539733686 no 2664 0.217528677475379 3803 17682963 SGTC_3209 9113616 49.47 µM -0.780963635430932 0.219751514232073 no 2665 0.217411941431664 3778 16649353 SGTC_1945 st075991 56.6 µM -0.78237942829781 0.21930941203792 no 2666 0.216995809969339 3806 1084980 SGTC_1468 k284-1086 134 µM -0.78303557387912 0.219104694376468 no 2667 0.21680311111487 3799 15996457 SGTC_2558 carylophyllene oxide 100 µM -0.783048946161261 0.219100523362366 no 2668 0.21679918493094 3897 6708694 An oxygenated terpenoid and antifungal agent. SGTC_2154 5570129 200 µM -0.7858838057784 0.218217319712552 no 2669 0.215967781388464 3831 673366 SGTC_867 0518-0118 155 µM -0.789886272005411 0.216973846630892 no 2670 0.214797094659702 3827 6848158 SGTC_3211 9128781 49.47 µM -0.789893992203999 0.216971452108936 no 2671 0.214794840136875 3867 17194361 SGTC_465 cgp-37157 41 µM -0.790345180593913 0.216831536579158 no 2672 0.214663103869244 3764 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange. SGTC_2441 5730946 39.09 µM -0.790381029789034 0.216820421821536 no 2673 0.214652638771842 3901 1774275 SGTC_1760 st045453 10.4495 µM -0.791178916689849 0.216573128606555 no 2674 0.214419796371129 3875 3323419 YIL048W NEO1 SGTC_2311 7694451 200 µM -0.791487693192272 0.216477471716696 no 2675 0.214329727466209 3788 2163142 SGTC_1805 st050013 60.3 µM -0.793438786991795 0.215873601521586 no 2676 0.213761110048441 3777 4037144 SGTC_525 k781-2675 26.7 µM -0.793789878236855 0.215765041308093 no 2677 0.213658883055924 3820 3651118 YDL195W SEC31 SGTC_1325 1431-0015 227 µM -0.793945250079572 0.215717009197519 no 2678 0.213613652637208 3790 1103340 SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM -0.795098975214205 0.215360537158025 no 2679 0.213277965365898 3882 5024745 SGTC_3330 9141424 71.43 µM -0.797575028118362 0.214596654025829 no 2680 0.212558573615695 3903 27261020 SGTC_837 0091-0265 12.5 µM -0.798595609629506 0.214282254984471 no 2681 0.212262467107161 3800 759367 SGTC_174 3553-0389 74.3 µM -0.799362254197072 0.214046259767792 no 2682 0.212040195280108 3826 738071 SGTC_811 0416-0114 265 µM -0.799414303431748 0.214030243004108 no 2683 0.212025109678576 3882 6612453 SGTC_1850 st056238 17 µM -0.799643451877176 0.21395973697854 no 2684 0.21195870229294 3835 5393177 SGTC_2706 st078239 82.5 µM -0.799689504854065 0.213945568702568 no 2685 0.211945357575172 3809 15434492 SGTC_3178 9107506 49.47 µM -0.799948800317166 0.213865806212022 no 2686 0.211870231002775 3864 8897194 SGTC_2905 7799065 20.05 µM -0.800420838547773 0.21372064587657 no 2687 0.211733505734664 3730 1296806 SGTC_2804 7954240 19.48 µM -0.80211199120627 0.213201057037795 no 2688 0.211244089603186 3878 828705 SGTC_59 0330-0160 1.33 µM -0.803673140115385 0.21272206505261 no 2689 0.210792885179643 3804 4293482 SGTC_381 3461-2219 42.7 µM -0.803718227579374 0.212708240650469 no 2690 0.210779862370908 3803 2883159 SGTC_2357 9067248 200 µM -0.805671734953988 0.2121097738116 no 2691 0.210216075611484 3855 9150235 SGTC_246 cycloheximide 667 µM -0.80636389221091 0.21189796438887 no 2692 0.210016530111268 3719 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells. SGTC_90 0870-0863 4.608 µM -0.808458399823884 0.211257771105189 no 2693 0.209413372344499 3832 1738164 SGTC_2396 5342950 42.78 µM -0.809310911368778 0.210997522913971 no 2694 0.209168165770428 3855 1886677 SGTC_1479 0549-0158 134 µM -0.810648001229918 0.210589725143623 no 2695 0.208783921347849 3882 5440202 SGTC_688 0527-0193 473 µM -0.812388621931985 0.210059548394295 no 2696 0.208284336478331 3867 4007154 SGTC_2933 9026794 32.47 µM -0.815602733904856 0.209082623593203 no 2697 0.207363692663049 3865 17586027 SGTC_494 Boc-Gly-Val-Val-CHO 140 µM -0.818441382644995 0.208222049341584 no 2698 0.206552600040424 3888 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA. SGTC_2540 epiandrosterone 100 µM -0.81952881545059 0.20789293403827 no 2699 0.206242384258072 3906 441302 A steroid. SGTC_1572 epiandrosterone 68.9 µM -0.821044993683259 0.207434570528334 no 2700 0.205810320027283 3780 441302 A steroid. SGTC_599 1935-0052 86.5 µM -0.821562448374236 0.207278273020041 no 2701 0.205662984345982 3854 9557311 SGTC_2088 5278280 127.392 µM -0.821927031415523 0.207168192318082 no 2702 0.205559213651491 3923 791502 SGTC_91 0417-1751 58.384 µM -0.823800864571614 0.206602960674884 no 2703 0.205026358136269 3960 6795624 SGTC_3128 9127691 49.47 µM -0.825807440285437 0.205998701811444 no 2704 0.204456666405397 3911 41316314 SGTC_1606 st000094 49.2 µM -0.826826651419707 0.205692179088133 no 2705 0.204167660901601 3866 1242210 SGTC_1668 st014914 51.6 µM -0.828659661670713 0.205141591982844 no 2706 0.203648508805443 3885 2839556 SGTC_1416 3966-0321 25.3 µM -0.829344038957679 0.204936248154322 no 2707 0.203454878871287 3890 582530 YLR208W SEC13 SGTC_2691 st077356 60.2 µM -0.831017535787648 0.204434639223145 no 2708 0.202981861559846 3945 2839272 SGTC_2828 7998861 71.43 µM -0.832305252319146 0.204049160898469 no 2709 0.202618333347683 3792 2988188 SGTC_2102 5377816 72.7585 µM -0.833226159793051 0.203773752729405 no 2710 0.202358595806563 3920 1379702 SGTC_1430 4049-0248 69.1 µM -0.834465970763303 0.203403322919776 no 2711 0.202009227732256 3890 22774488 SGTC_808 0711-0032 135 µM -0.835069125688401 0.203223258097042 no 2712 0.201839394474324 3825 4252555 SGTC_1959 st077091 55.8 µM -0.836510357324769 0.202793380779464 no 2713 0.201433926243523 3882 821356 YKL052C ASK1 SGTC_2064 5220758 200 µM -0.837370653322616 0.202537038734287 no 2714 0.201192128098552 3955 788518 SGTC_1892 st058411 7.36 µM -0.838643351904114 0.202158168708456 no 2715 0.200834737831066 3919 3934738 SGTC_1611 st001856 99.4 µM -0.839770010917039 0.201823127349901 no 2716 0.200518675504339 3874 647478 SGTC_2883 9059145 45.46 µM -0.840910882290558 0.20148419859991 no 2717 0.200198930751569 3869 16476510 SGTC_2624 nerol 100 µM -0.841036002573603 0.201447048775682 no 2718 0.200163882741418 3807 637566 A natural product oil. SGTC_3329 9141233 27.5565 µM -0.841611101730351 0.201276347227818 no 2719 0.200002836542195 3879 4909101 YNL103W MET4 SGTC_2260 7964312 200 µM -0.843434033512935 0.20073583603508 no 2720 0.199492872283788 3950 231951 SGTC_2866 9034245 58.44 µM -0.846113092699994 0.199943060439962 no 2721 0.198744828764638 3870 6462273 SGTC_1288 0973-0013 65.5 µM -0.846509155875463 0.199826019086573 no 2722 0.198634384175664 3934 4315430 SGTC_1342 1486-1464 234 µM -0.849150433486462 0.199046544593412 no 2723 0.197898795037017 3923 3253938 SGTC_1212 0520-0165 585 µM -0.851744427792835 0.198282809879497 no 2724 0.197177978143628 4008 5403258 SGTC_2735 sertaconazole 140 nM -0.852903282913099 0.197942187231222 no 2725 0.196856470504038 4003 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C SGTC_2419 paclitaxel 166.5 µM -0.853111032359992 0.197881160752638 no 2726 0.196798866986617 3840 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_674 0498-0004 451 µM -0.853881301298663 0.197654993173805 no 2727 0.196585380543675 3919 4231473 SGTC_732 3970-1727 52.7 µM -0.85478973921752 0.197388457084953 no 2728 0.196333779815563 3966 1275699 SGTC_3222 9128301 49.47 µM -0.856087949956624 0.197007938963211 no 2729 0.195974566688724 3939 4911358 SGTC_1673 st016611 27.3 µM -0.856430987461646 0.19690746556344 no 2730 0.195879715321403 3959 5226799 SGTC_2764 methyldopa 94.69 µM -0.857429026576217 0.196615323029169 no 2731 0.195603911614503 3883 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent. SGTC_2319 6033012 152.6 µM -0.858153704116352 0.196403362583506 no 2732 0.195403798009266 3874 847246 SGTC_3191 9110352 49.47 µM -0.860323348838327 0.195769593176706 no 2733 0.194805412803535 3872 17122424 SGTC_2788 5282734 71.43 µM -0.861487158931168 0.19543014764604 no 2734 0.194484895267781 3992 743706 SGTC_2846 9008642 19.48 µM -0.863775744895754 0.1947636851459 no 2735 0.193855547292764 3995 2992898 SGTC_3320 9137005 35.139 µM -0.865600684579884 0.194233233813131 no 2736 0.193354590030237 3943 4908713 SGTC_3083 9117465 49.47 µM -0.865712726335242 0.19420069556724 no 2737 0.193323859632521 3893 16420915 SGTC_385 1494-0393 12.4 µM -0.866883546547482 0.19386087422668 no 2738 0.193002909731224 3919 3090647 SGTC_1227 3909-8010 46.6 µM -0.86812745302013 0.19350023752703 no 2739 0.192662281843712 3925 15982272 SGTC_1865 st057639 52.2 µM -0.869401235169521 0.19313136359736 no 2740 0.19231385387073 3909 688818 SGTC_2714 st079313 56.9 µM -0.870438648493762 0.192831257013632 no 2741 0.192030366717004 3902 2939799 SGTC_1415 3966-0071 78.1 µM -0.870933159544081 0.192688303431525 no 2742 0.191895324967007 3861 2893185 SGTC_1252 0493-0875 34.8 µM -0.871141825882386 0.192628001461997 no 2743 0.19183835952415 3913 3960963 SGTC_838 0109-0203 71.4 µM -0.872940079523512 0.192108806697874 no 2744 0.191347869472625 3948 759422 SGTC_2095 5432005 200 µM -0.873708482050073 0.191887213601417 no 2745 0.191138515277679 3943 783734 SGTC_1655 st012546 55.1 µM -0.873770801864368 0.191869248580191 no 2746 0.191121542166314 3909 720985 YLR208W SEC13 SGTC_2132 5317594 122.667 µM -0.874400564192015 0.191687763880985 no 2747 0.190950075126105 3911 794577 SGTC_3292 9120825 59.784 µM -0.874825968503632 0.191565230520297 no 2748 0.190834302595794 3903 24824900 SGTC_507 nimesulide 162 µM -0.875369590976146 0.191408715481337 no 2749 0.190686420039019 3985 4495 A COX2 inhibitor. SGTC_2508 celastrol 40.54 µM -0.875959363233588 0.191239002050748 no 2750 0.190526062846023 3876 122724 Celastrol is a natural product and antioxidant. SGTC_1710 st031758 61.5 µM -0.876446739468011 0.191098823833252 no 2751 0.190393609304888 3975 5394341 SGTC_1797 st048695 56.8 µM -0.876924468760419 0.190961481416773 no 2752 0.190263832397591 3915 592262 YIL048W NEO1 SGTC_2938 9059746 27.26 µM -0.877570642291974 0.190775809318469 no 2753 0.190088383482514 3965 6471769 SGTC_3116 9124943 49.47 µM -0.881492983634372 0.189651138877058 no 2754 0.189025524986024 3928 41905195 YPL160W CDC60 SGTC_1377 2944-0135 198 µM -0.883883289251804 0.188967760208551 no 2755 0.188379609446631 4010 1894137 SGTC_1951 sophoraflavanone G 9.2 µM -0.885951450215106 0.188377707141121 no 2756 0.187821844784839 3923 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity. SGTC_1164 k060-0068 93.7 µM -0.886050309304591 0.188349530810181 no 2757 0.187795208931318 3942 5963676 SGTC_3102 9121669 49.47 µM -0.887455472303809 0.187949319311717 no 2758 0.18741686460648 3961 41905072 SGTC_1407 3909-7909 12.3 µM -0.887547575078656 0.187923105407392 no 2759 0.18739208212378 3925 4411780 SGTC_2589 lobaric acid 100 µM -0.888356558897565 0.187692952841383 no 2760 0.187174492475871 3972 73157 A novel microtubule depolymerizer. SGTC_1995 st072814 61.1 µM -0.891164790325737 0.186895374737315 no 2761 0.186420385264167 3947 5769371 SGTC_1905 st060207 84.5 µM -0.892463755375791 0.186527160459231 no 2762 0.186072205742084 3907 1948547 SGTC_1998 st075797 76.8 µM -0.892784609310617 0.186436278057401 no 2763 0.185986264959167 3894 24208315 SGTC_1265 0819-1001 68.8 µM -0.894485395623716 0.185954985731099 no 2764 0.185531120143763 3924 3106768 SGTC_1281 0884-0031 11.8 µM -0.895246492496272 0.185739858569485 no 2765 0.185327668250698 3980 1548255 SGTC_337 1315-0038 354 µM -0.897222276716998 0.185182116019406 no 2766 0.184800160229644 3938 1626437 SGTC_2460 5552655 174.22 µM -0.897646669524782 0.185062450359846 no 2767 0.184686974894592 3995 5401989 SGTC_2742 clothiapine 36.27 µM -0.898370959625292 0.184858333912852 no 2768 0.184493906683757 3915 16351 An atypical antipsychotic. YIL048W NEO1 SGTC_175 3793-3120 23.7 µM -0.899597925793751 0.184512874797656 no 2769 0.184167130719202 3982 5322297 SGTC_1074 carmofur 3.8 µM -0.900723841992203 0.184196220395672 no 2770 0.18386758440915 4000 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_297 0986-0032 24 µM -0.901655114154069 0.183934563713042 no 2771 0.183620051933116 3928 2847425 SGTC_439 amiodarone 34.4 µM -0.901919228830292 0.183860398373791 no 2772 0.183549887972099 3843 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1 SGTC_186 3455-3465 67.277 µM -0.903105243274395 0.183527586472383 no 2773 0.183235020745806 3922 755278 SGTC_1753 st043925 64 µM -0.904161629635721 0.183231466360544 no 2774 0.18295485145392 4022 670181 SGTC_362 0310-0100 9.03 µM -0.904881425535195 0.183029868126024 no 2775 0.182764104144497 4061 790235 SGTC_3174 9107204 49.47 µM -0.904895736908888 0.183025861243876 no 2776 0.182760312861897 4027 3938802 SGTC_492 tmb-8 126 µM -0.905429380825696 0.182876491296821 no 2777 0.182618978191095 3903 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1 SGTC_427 1354-0053 47.3 µM -0.908445941294225 0.182033570267475 no 2778 0.181821331319598 4091 6813657 SGTC_2304 7443016 91.4 µM -0.910355468363509 0.181501246511419 no 2779 0.181317537295488 3909 939854 SGTC_2501 sodium tetradecyl sulfate 13.37 µM -0.91040228481147 0.181488207619657 no 2780 0.181305196614397 4001 23665772 A membrane-active detergent. SGTC_2969 9091408 28.7 µM -0.912946324765887 0.18078054652449 no 2781 0.180635385983526 3939 4286311 SGTC_1981 st071826 47 µM -0.913017670268204 0.180760725720581 no 2782 0.180616624093092 4006 11838600 SGTC_2894 9048625 32.47 µM -0.914089143585095 0.18046321895008 no 2783 0.180335003300959 3964 4092861 SGTC_548 1436-0017 110 µM -0.914371984430411 0.180384736240284 no 2784 0.180260708790943 4068 9677137 SGTC_1978 st071761 42 µM -0.914767086149661 0.180275139227381 no 2785 0.180156958600249 4011 5147680 SGTC_2568 diosmetin 100 µM -0.915840295266574 0.179977653407994 no 2786 0.179875332684759 4045 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.  SGTC_2646 retinol 96.75 µM -0.920260114549428 0.178755762984852 no 2787 0.178718423378088 4000 445354 A vitamin A analog and teratogen. SGTC_1974 st069448 26.9 µM -0.921982651961391 0.178280972940049 no 2788 0.178268812331118 3974 6323587 YNR016C ACC1 SGTC_736 0958-0254 92.6 µM -0.926526204174166 0.177032432073258 no 2789 0.177086292810274 4096 6812352 SGTC_3189 9110682 49.47 µM -0.926856292150339 0.176941941642952 no 2790 0.177000576566936 4103 17122418 SGTC_2355 9061122 103.12 µM -0.928182445839332 0.176578684103751 no 2791 0.176656469298755 4029 5302957 SGTC_1387 3342-1166 1.8 µM -0.928945733095468 0.176369819885754 no 2792 0.176458605230247 3985 3418228 SGTC_681 1642-0006 26.6 µM -0.929176780274344 0.176306627482957 no 2793 0.176398739394692 4028 4446530 SGTC_384 k007-0144 5.16 µM -0.930065672633748 0.176063645186493 no 2794 0.176168541397114 3979 6824886 SGTC_265 mycophenolic acid 32.932 µM -0.932760819816919 0.175328212551278 no 2795 0.175471737370423 4092 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1 SGTC_404 fumagillin 50 µM -0.934472690953046 0.174862102293929 no 2796 0.175030058265667 3992 12015870 A methionine aminopeptidase binder. SGTC_2664 lyso-paf C-16 73.48 µM -0.934604135099927 0.174826345069808 no 2797 0.174996173603558 3984 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_2065 5221596 34.26 µM -0.935090772848028 0.174694003652847 no 2798 0.174870760691858 4010 788581 SGTC_1098 clofazimine 15.1 µM -0.93647665789277 0.174317460013444 no 2799 0.174513912623674 4082 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2 SGTC_2852 9023854 51.95 µM -0.942034460704968 0.172812596067297 no 2800 0.17308749853466 4101 19798528 SGTC_666 0272-0154 136 µM -0.942109765969325 0.172792262983066 no 2801 0.173068222519648 4030 6870312 SGTC_855 0428-0020 25 µM -0.942500684721244 0.172686735983465 no 2802 0.172968180365363 4045 6812414 SGTC_3352 9151559 45.5865 µM -0.942777766373472 0.172611963753321 no 2803 0.172897293203179 4023 17159339 SGTC_1168 k815-0004 80.5 µM -0.944162218479174 0.172238669940748 no 2804 0.172543379398627 4013 642433 SGTC_2519 cryptotanshinone 88.04 µM -0.945216140970158 0.171954843376619 no 2805 0.172274270311135 4010 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE) SGTC_2287 7945887 168.79 µM -0.945285726337993 0.171936114205946 no 2806 0.172256511778434 4045 1245853 SGTC_2851 9015922 71.43 µM -0.949724161597255 0.170744183797766 no 2807 0.171126214734744 4055 2996893 SGTC_329 k048-0121 21.3 µM -0.950952994812856 0.1704151208156 no 2808 0.170814118948763 4056 6832902 SGTC_100 0086-0128 49.5915 µM -0.952998554445295 0.169868252289455 no 2809 0.17029540156098 4095 93297 SGTC_1645 Cervolide 78 µM -0.954690248186667 0.169416838799907 no 2810 0.169867181422778 4014 23173 A fragrance. SGTC_294 k038-0071 157 µM -0.956532019550876 0.168926254598149 no 2811 0.16940175770096 4032 24152826 SGTC_3118 9124250 49.47 µM -0.958042595272024 0.168524571348304 no 2812 0.169020640060985 3980 1504786 SGTC_413 propylparaben 100 µM -0.958966135175939 0.168279291888875 no 2813 0.168787902804439 3990 7175 A pharmaceutical preservative. SGTC_2499 avocadenofuran 51.48 µM -0.959189649208989 0.168219964174778 no 2814 0.168731606974448 4009 6857792 A insecticide and lysyl oxidase inhibitor. SGTC_1669 st015249 58.4 µM -0.960625854950857 0.167839070678514 no 2815 0.168370161923398 4112 722793 SGTC_2669 eugenol 100 µM -0.961644045873863 0.167569374750945 no 2816 0.168114219120398 4035 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism. SGTC_2045 5106652 78.05 µM -0.962884689753068 0.167241133551069 no 2817 0.167802696832308 4007 673349 SGTC_382 3229-0966 23.2 µM -0.963774883724889 0.167005867580978 no 2818 0.167579400728544 4068 5722370 SGTC_692 k241-0027 77.8 µM -0.963804823222601 0.166997958696947 no 2819 0.167571894038504 4107 3600480 SGTC_952 1185-0122 232 µM -0.964858662900654 0.166719727962259 no 2820 0.167307804233007 3975 678600 SGTC_1006 4099-6547 255 µM -0.967588539326924 0.166000388243442 no 2821 0.166624951618761 4095 3146833 SGTC_3253 9135987 49.47 µM -0.969440558500716 0.16551351307212 no 2822 0.166162712185623 4063 4182430 SGTC_2687 chenodiol 100 µM -0.970327405704523 0.165280698221877 no 2823 0.165941660465646 4146 5702181 A cholesterol synthesis inhibitor. SGTC_132 0417-1715 25.805 µM -0.971895556154756 0.164869546789053 no 2824 0.165551255390829 4005 6769098 SGTC_114 0364-0001 490.298 µM -0.972193976641046 0.164791379377222 no 2825 0.165477028278967 4118 4003655 SGTC_944 3370-0224 231 µM -0.972365255110118 0.164746526028174 no 2826 0.165434435345984 4100 4580514 SGTC_2153 5569715 200 µM -0.972707602126698 0.164656898007494 no 2827 0.165349322940099 4079 2054701 SGTC_986 1493-0483 84 µM -0.972794758150545 0.164634085206751 no 2828 0.165327659221062 3989 40079 SGTC_2478 5763493 32.33 µM -0.979384381306737 0.162915205122302 no 2829 0.16369504569672 3996 1365576 YLR208W SEC13 SGTC_1388 3346-4487 254 µM -0.979644330650284 0.162847638334496 no 2830 0.163630857197202 4125 3345614 SGTC_137 0438-0332 85.389 µM -0.983519802227517 0.161842475837477 no 2831 0.162675837085998 4045 2063393 YER012W | YPR107C PRE1 | YTH1 SGTC_2978 9011784 42.97 µM -0.984330093041049 0.161632826649235 no 2832 0.162476618921762 4058 2994934 SGTC_2240 6690706 185.951 µM -0.984438136871782 0.161604885498032 no 2833 0.162450067258057 3917 805876 SGTC_3140 9094243 49.47 µM -0.984684715958694 0.161541129619697 no 2834 0.162389481269952 4059 19291112 SGTC_3351 9150312 21.596 µM -0.986881831881113 0.160973764010395 no 2835 0.161850285904409 3993 4904905 SGTC_2655 perillic acid 100 µM -0.987792886086031 0.160738882610079 no 2836 0.161627046148694 4099 5702197 An apoptosis inducer. SGTC_280 3448-3607 3.04 µM -0.989901244287257 0.160196179625681 no 2837 0.161111195633936 4054 626179 SGTC_58 0957-0393 9 µM -0.991474104407741 0.15979209778578 no 2838 0.160727065492706 3877 6997992 SGTC_1045 1348-1485 165 µM -0.993527574293152 0.159265547456781 no 2839 0.160226459788136 4070 6810614 SGTC_691 1548-0686 185 µM -0.994111296332476 0.15911607721961 no 2840 0.160084343189037 4077 46495133 SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM -0.994896265617322 0.158915219719923 no 2841 0.159893359663469 4060 442882 SGTC_2567 aureobasidin a 60 nM -0.994987082084039 0.158891992382152 no 2842 0.159871273581824 4241 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1 SGTC_631 k072-0230 41.5 µM -0.996341573146143 0.158545830056652 no 2843 0.15954210540289 4109 5773147 SGTC_1616 st002734 56.1 µM -0.996669714082936 0.158462042757229 no 2844 0.159462427450158 4029 4026101 SGTC_524 r073-0010 27.8 µM -0.997866724028751 0.158156645255497 no 2845 0.159171994851618 4007 2772106 SGTC_172 1112-0046 2.638 µM -0.998412027038206 0.158017648274005 no 2846 0.159039801983133 4070 2802135 YIL048W NEO1 SGTC_1585 2',4'-dihydroxychalcone 10.4 µM -1.00070452882038 0.157434170300091 no 2847 0.158484838634738 4113 5357218 A potent inhibitor of glutathione S-transferases. SGTC_967 1306-0166 352 µM -1.00094948453728 0.15737190903714 no 2848 0.158425615540866 4090 4437607 SGTC_2322 7413319 38.22 µM -1.0011018895945 0.157333179872265 no 2849 0.158388775803576 4129 1840400 SGTC_626 0214-0009 33 µM -1.00186146341417 0.157140250453136 no 2850 0.158205253500074 4160 3437874 SGTC_2470 5664817 21.68 µM -1.00665764303779 0.155925629714786 no 2851 0.157049661763153 4118 2859561 SGTC_714 4296-0578 26.1 µM -1.007876927347 0.155617838222492 no 2852 0.156756774692718 4125 1589775 SGTC_2122 5258151 111.688 µM -1.0092380656152 0.155274711363301 no 2853 0.156430237470206 4089 2173356 SGTC_2180 6301957 200 µM -1.0098856674581 0.155111634040673 no 2854 0.156275035088528 4123 845462 SGTC_1807 st050092 58.9 µM -1.01606965467756 0.153560096428647 no 2855 0.154798109116083 4132 5008496 SGTC_1085 doxorubicin 7.67 µM -1.01610213563537 0.15355197431351 no 2856 0.15479037609047 4135 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_1813 st051246 8.6015 µM -1.0198293522908 0.152621844222145 no 2857 0.153904699918904 4031 5291959 SGTC_2918 7977171 22.06 µM -1.01997725060867 0.152585013336443 no 2858 0.153869625042898 4083 2236483 SGTC_1282 0886-0010 32.4 µM -1.02160553608609 0.152179913828329 no 2859 0.153483818205508 4161 2836211 YNL267W PIK1 SGTC_2945 9067681 61.76 µM -1.02323883387979 0.151774285374943 no 2860 0.153097467953795 4180 16456930 SGTC_929 2805-0021 398 µM -1.02377059208237 0.151642378743063 no 2861 0.152971821832021 4183 3098024 SGTC_2084 5306078 60.6385 µM -1.02584787138408 0.151127824373046 no 2862 0.152481648639117 4030 679340 SGTC_2250 alverine citrate 130 µM -1.02613309003063 0.151057264835 no 2863 0.152414427396984 4002 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1 SGTC_3208 9114115 49.47 µM -1.02827144689609 0.150528960340643 no 2864 0.151911079175232 4133 650895 SGTC_411 enrofloxacin 100 µM -1.02882442277524 0.150392542118291 no 2865 0.15178109399798 4205 71188 A bacterial gyrase inhibitor. SGTC_1001 4048-4355 44.4 µM -1.03433295920339 0.14903809353602 no 2866 0.150490266844793 4103 21824233 SGTC_2067 5224629 34.075 µM -1.0348192256754 0.14891892211948 no 2867 0.150376671288099 4143 2835000 SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM -1.03819164114619 0.148094182042987 no 2868 0.149590421712064 4171 6708760 SGTC_1992 st073643 23.3 µM -1.04093997288659 0.14742432929957 no 2869 0.148951704170059 4105 3161292 SGTC_2516 gossypol 71.55 µM -1.04186725033424 0.147198782102039 no 2870 0.148736614815209 4169 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_1391 3442-0225 151 µM -1.04393064205612 0.146697721535182 no 2871 0.148258740025896 4110 5227075 SGTC_2303 7774051 200 µM -1.04426108842454 0.146617584538865 no 2872 0.148182305251771 4188 2953184 SGTC_490 phenamil 164 µM -1.04462046311722 0.146530465450106 no 2873 0.148099209069729 4110 4755 Irreversibly blocks amiloride-sensitive Na+ channels. SGTC_3161 9100388 49.47 µM -1.04463279546922 0.146527476476074 no 2874 0.148096358083094 4199 25236368 SGTC_735 3076-0345 636 µM -1.04712909719434 0.145923293959798 no 2875 0.147520020471709 4205 2888990 SGTC_751 0833-0568 350 µM -1.04748238277756 0.145837923299916 no 2876 0.147438576643493 4164 6954252 SGTC_1172 0370-0043 85 µM -1.04999075561163 0.145232746067752 no 2877 0.146861181505997 4168 376585 SGTC_3121 9125696 49.47 µM -1.05284417350703 0.144546379418419 no 2878 0.146206207875229 4240 1235365 SGTC_814 3342-0569 96 µM -1.05398550763851 0.144272453588973 no 2879 0.145944776137698 4215 4346283 SGTC_2533 agelasine 13.65 µM -1.0556807877132 0.143866224270826 no 2880 0.145557038764385 4216 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase. SGTC_320 4092-0846 5.34 µM -1.05977038127717 0.142889439127834 no 2881 0.144624537306892 4112 1359356 SGTC_3025 9087895 49.47 µM -1.06145379844487 0.142488666069906 no 2882 0.144241859456358 4152 17173641 SGTC_168 3970-0862 530.542 µM -1.06256083547635 0.142225527256339 no 2883 0.14399057789045 4121 3135186 SGTC_2111 5486399 200 µM -1.06618306024475 0.141366836470915 no 2884 0.143170449082574 4133 689674 SGTC_2046 4110841 106 µM -1.06640015974564 0.141315482343391 no 2885 0.143121394758127 4152 44119630 YMR134W ERG29 SGTC_3350 9150499 3.57 µM -1.06778658066862 0.140987827573996 no 2886 0.142808396327232 4138 4910996 YPR165W RHO1 SGTC_485 niflumic acid 177 µM -1.06872612986171 0.140766075759222 no 2887 0.14259654688799 4216 4488 A COX2 inhibitor. SGTC_2152 5568786 200 µM -1.07055953179964 0.140334039182817 no 2888 0.142183763860911 4161 5399883 SGTC_2853 9015042 58.44 µM -1.07521772176794 0.139240402127282 no 2889 0.141138631483314 4090 6457456 SGTC_655 k060-0012 42 µM -1.07754773224659 0.138695550388518 no 2890 0.140617819208903 4156 5994525 SGTC_549 1661-1316 519 µM -1.07948445930364 0.138243771073422 no 2891 0.140185908985171 4198 2857282 SGTC_891 0929-0073 133 µM -1.08076212603378 0.137946280252214 no 2892 0.13990146989372 4208 5603632 SGTC_1478 0453-0656 35.7 µM -1.08082680060082 0.137931233102249 no 2893 0.139887082229838 4163 5258496 SGTC_3068 9116768 49.47 µM -1.085580031251 0.136828413202132 no 2894 0.138832419178217 4165 41904888 SGTC_3087 9117406 49.47 µM -1.08893494201189 0.136053662097034 no 2895 0.138091288042214 4207 42546093 SGTC_860 0443-0016 25.1 µM -1.08943380462702 0.135938716485015 no 2896 0.137981315479296 4201 5337942 SGTC_1358 1509-0022 2.48 µM -1.08979158651934 0.13585631899411 no 2897 0.137902480474935 4222 3258434 SGTC_1217 1183-1422 255 µM -1.08991016835638 0.135829017038301 no 2898 0.137876358489083 4217 2849664 SGTC_2807 7945238 51.95 µM -1.09018226100674 0.135766385377892 no 2899 0.137816432893031 4215 17148797 SGTC_2006 4011487 200 µM -1.09068993797997 0.135649578616988 no 2900 0.137704669799895 4207 45595294 SGTC_2326 6164455 177.58 µM -1.09146378972196 0.135471662612997 no 2901 0.13753442840198 4146 2888790 SGTC_635 k038-0028 24.7 µM -1.09150180959452 0.135462925599475 no 2902 0.137526068028498 4189 4035102 SGTC_1659 st012954 42.1 µM -1.09289477117965 0.135143087527844 no 2903 0.137220002162868 4149 24207262 SGTC_440 fluspirilene 35.1 µM -1.09680460250588 0.134248118683369 no 2904 0.136363408910485 4269 3396 An atypical antipsychotic. SGTC_2916 7875993 68.79 µM -1.0983585883465 0.133893540977568 no 2905 0.136023968901488 4022 1299250 SGTC_1915 st067105 30.6 µM -1.10240044776454 0.132974313614563 no 2906 0.135143808482212 4135 69751 YOR207C | YOR116C RET1 | RPO31 SGTC_195 4234-0266 16.654 µM -1.10328698215493 0.132773274244861 no 2907 0.13495127900656 4194 2303354 SGTC_1550 gossypolone 36.6 µM -1.1050689734795 0.132369805639015 no 2908 0.134564851714254 4217 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_398 bronopol 33.3 µM -1.10878289288892 0.131531638441136 no 2909 0.133761926057299 4127 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them. SGTC_284 0988-0104 32.6 µM -1.1123946099301 0.13072005704482 no 2910 0.132984260560359 4190 4666532 SGTC_534 k292-0788 63.4 µM -1.11401231849515 0.130357669962357 no 2911 0.132636951003341 4264 4146317 SGTC_2629 bisabolol 100 µM -1.11407449427646 0.130343755686475 no 2912 0.132623614823014 4246 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer. SGTC_1395 3486-0190 4.35 µM -1.11652955864139 0.129795159576059 no 2913 0.132097762467335 4204 6748079 SGTC_583 1488-1091 88.9 µM -1.11781532245407 0.12950848821072 no 2914 0.131822938003531 4323 4303273 SGTC_1809 st050081 57.6 µM -1.12117732535536 0.128760976806608 no 2915 0.131106194706095 4292 5036894 SGTC_2128 5255449 168.493 µM -1.1218283409769 0.128616575904765 no 2916 0.13096771679765 4167 736008 SGTC_852 0418-0143 439 µM -1.12340970300133 0.128266284261883 no 2917 0.130631765381369 4218 5369229 SGTC_2305 7443522 69.23 µM -1.12880698840106 0.127075708967646 no 2918 0.129489631986507 4126 5415886 SGTC_647 0140-0236 81 µM -1.12897777052892 0.127038162451006 no 2919 0.129453605618933 4233 990837 SGTC_2149 5554786 194.827 µM -1.12922781589973 0.126983203808081 no 2920 0.129400871255884 4250 745063 YPR165W RHO1 SGTC_586 0957-0265 8.15 µM -1.12953895827131 0.126914839479837 no 2921 0.129335272374467 4080 6752309 YPR165W | YPR107C RHO1 | YTH1 SGTC_2041 5107442 45.335 µM -1.12956896183259 0.126908248439835 no 2922 0.129328947871328 4260 793005 SGTC_1853 st056710 91.2 µM -1.13140599286441 0.126505152014905 no 2923 0.128942125145455 4279 269167 SGTC_3171 9103192 49.47 µM -1.13283792780252 0.126191564298161 no 2924 0.128641160338791 4291 13018434 SGTC_2333 9017922 200 µM -1.13382236388321 0.125976291482858 no 2925 0.12843453404062 4260 3163164 SGTC_1828 st055811 49 µM -1.13437274819453 0.125856047157982 no 2926 0.128319112659048 4224 5877589 SGTC_285 1486-1325 46 µM -1.13613835817864 0.125470848735552 no 2927 0.127949331847635 4272 22310230 SGTC_1893 st059353 36.1 µM -1.13653654454634 0.125384091305365 no 2928 0.12786604003778 4240 3112488 SGTC_2456 5770359 74.46 µM -1.13695833931246 0.125292235724324 no 2929 0.127777850974598 4243 3118787 SGTC_1615 st002656 86.5 µM -1.13769739171798 0.12513140324073 no 2930 0.127623431467769 4226 1584458 SGTC_468 gf-109203x 121 µM -1.14050459713135 0.124521813731552 no 2931 0.127038069280377 4227 2396 A protein kinase C inhibitor. SGTC_2761 levamisole 97.89 µM -1.14077732958007 0.124462700253292 no 2932 0.126981298495798 4256 26879 An alkaline phosphatase inhibitor. SGTC_1333 1482-0047 286 µM -1.14237180283075 0.12411749834182 no 2933 0.126649753357509 4247 3811116 SGTC_279 1273-0055 2.93 µM -1.14310936639773 0.123958043350224 no 2934 0.126496592958945 4245 2847562 SGTC_75 0159-0059 199.013 µM -1.14447606476492 0.123662953823624 no 2935 0.126213129347017 4316 5377270 SGTC_1914 st062367 72.6 µM -1.14622856741728 0.123285283941374 no 2936 0.12585029525787 4232 978205 SGTC_2656 pseudo-anisatin 100 µM -1.14863131715075 0.122768798488735 no 2937 0.125354018927386 4265 6708809 A neurotoxin. SGTC_1071 trifluoperazine 6.31 µM -1.15296520132026 0.121841045306749 no 2938 0.124462333991202 4317 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. SGTC_2308 7584454 197.62 µM -1.15356917650914 0.121712144602877 no 2939 0.124338420708689 4300 893577 SGTC_119 0121-0043 24.815 µM -1.15571759391102 0.121254405011217 no 2940 0.123898344631225 4260 1092378 SGTC_596 1155-0152 116 µM -1.15662848214692 0.121060698024399 no 2941 0.123712090201942 4238 280313 SGTC_2523 spermine 47.74 µM -1.15663728791415 0.121058826477228 no 2942 0.123710290594549 4283 1103 A DNA binding polyamine. SGTC_2422 chlorphenesin carbamate 384.24 µM -1.15682006441722 0.121019984390287 no 2943 0.12367294126489 4222 2724 A muscle relaxant with antifungal properties. SGTC_1067 clotrimazole 1.36 µM -1.15782952264863 0.120805620967477 no 2944 0.123466806489627 4281 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_2301 7769476 200 µM -1.15851035613123 0.120661193618477 no 2945 0.123327913965484 4255 977820 SGTC_2034 5197015 53.07 µM -1.15967138156422 0.120415182124625 no 2946 0.123091313113489 4262 780676 SGTC_1921 5740136 50 µM -1.16058373592862 0.120222109970563 no 2947 0.122905611348176 4203 1774243 SGTC_433 pimozide 108 µM -1.16139272860706 0.120051093720943 no 2948 0.12274111234583 4160 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic SGTC_717 1532-0246 73.2 µM -1.16155498343739 0.120016814665401 no 2949 0.12270813836357 4229 9561992 SGTC_1034 k072-0165 12.7 µM -1.16210998203505 0.119899614058011 no 2950 0.122595396625482 4276 5835461 SGTC_87 0100-0052 35.5 µM -1.16258411135214 0.11979955476841 no 2951 0.122499140150162 4293 200187 YGR083C | YDR527W GCD2 | RBA50 SGTC_1289 0976-0073 69.1 µM -1.16353855451058 0.119598309611462 no 2952 0.122305532490512 4317 3391136 SGTC_1180 1193-0155 285 µM -1.16519153608969 0.119250341362608 no 2953 0.121970735455768 4328 2921347 SGTC_639 0833-0042 114 µM -1.17040397885885 0.118157754202608 no 2954 0.120919217612956 4263 5978911 YPR085C | YHR062C ASA1 | RPP1 SGTC_95 0471-0001 561.058 µM -1.17059485459037 0.118117879289307 no 2955 0.120880833270762 4257 4015405 SGTC_3163 9099914 49.47 µM -1.1710585621396 0.118021048065024 no 2956 0.120787619268311 4306 16268368 SGTC_1501 4491-0275 38.4 µM -1.1720008260909 0.117824457891148 no 2957 0.120598362244248 4241 5104718 SGTC_1503 4585-0012 61.3 µM -1.17344288174082 0.117524042039668 no 2958 0.120309124748489 4296 2922052 SGTC_1115 galangin 695.678 nM -1.17350132477955 0.117511878354183 no 2959 0.120297412962771 4335 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_3250 9135583 49.47 µM -1.17382102445439 0.117445355385687 no 2960 0.120233360451793 4299 7699353 SGTC_927 2425-1185 123 µM -1.17425138287268 0.117355848707792 no 2961 0.12014717517516 4200 730375 SGTC_3078 9116413 49.47 µM -1.1746160110687 0.117280050527197 no 2962 0.120074187367562 4187 17177322 SGTC_2572 astragaloside iv 100 µM -1.1758965321146 0.117014133109919 no 2963 0.119818112415766 4301 45006101 An anti-inflammatory agent. SGTC_2867 9039098 71.43 µM -1.17622837227788 0.116945291798078 no 2964 0.11975181483284 4229 6463460 SGTC_1210 3013-0140 750 nM -1.17757244698995 0.116666752753799 no 2965 0.119483549827576 4284 905973 SGTC_1042 0350-0096 82 µM -1.17821834648943 0.116533067380434 no 2966 0.119354785140318 4246 3122515 SGTC_231 b-estradiol 524 µM -1.17838028859971 0.116499566372349 no 2967 0.119322516181084 4239 450 A steroid. SGTC_1120 ficusin 1.78878 µM -1.17924099805598 0.116321625809571 no 2968 0.119151112546584 4296 6199 A DNA cross-linker. SGTC_906 1165-0455 526 µM -1.1802920570653 0.116104594562136 no 2969 0.118942038083702 4250 3252859 SGTC_1125 tnp00248 1.32998 µM -1.1823765227295 0.115675027632744 no 2970 0.118528167216009 4329 24207736 SGTC_2435 5706476 10.6 µM -1.1829532737868 0.115556370355621 no 2971 0.118413833206586 4261 5725375 SGTC_1709 st033179 39.1045 µM -1.18345565844441 0.115453083263454 no 2972 0.118314304994436 4263 573381 SGTC_3229 9132204 49.47 µM -1.18370678028562 0.115401478808361 no 2973 0.118264577028939 4333 17682924 SGTC_2347 9049783 174.81 µM -1.18932456137746 0.114251331699396 no 2974 0.117155986907713 4303 6467988 YPL169C MEX67 SGTC_2297 7971671 152.32 µM -1.18948295851915 0.114219021274974 no 2975 0.117124836533778 4288 909016 SGTC_317 4495-0002 170 µM -1.18959575589978 0.114196016422812 no 2976 0.117102657384112 4296 15991618 SGTC_378 3970-0959 8.33 µM -1.19008227318137 0.114096829783993 no 2977 0.117007028447939 4304 6615653 SGTC_2352 9027995 87.8 µM -1.19014259071014 0.114084537081674 no 2978 0.116995176403006 4234 2997347 SGTC_1150 3909-7983 10.9 µM -1.19352950551266 0.113395797573463 no 2979 0.116331031878475 4264 23965914 SGTC_395 anisomycin 6.25 µM -1.19399636004199 0.11330109432535 no 2980 0.11623969595198 4290 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_1685 st024049 53.0905 µM -1.19618948340857 0.112856965808878 no 2981 0.115811311943935 4293 1941139 SGTC_2058 5236698 133 µM -1.19997848436895 0.112092587886742 no 2982 0.115073848311158 4247 766665 SGTC_2210 7115885 190.385 µM -1.2019634391349 0.111693631518957 no 2983 0.114688846777098 4381 2927039 SGTC_475 α-linolenic acid 10 µM -1.20948480529313 0.110191129936436 no 2984 0.113238322591553 4299 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_2331 7980721 200 µM -1.21197037212411 0.109697803597076 no 2985 0.112761861076852 4242 2981221 SGTC_1185 1319-0113 81.3 µM -1.21409211016024 0.109277944755431 no 2986 0.112356276259347 4363 4672763 SGTC_2354 9060492 162 µM -1.21439061831584 0.109218967414632 no 2987 0.112299298119796 4327 6471895 SGTC_131 0141-0277 33.849 µM -1.22148768954554 0.107823503107281 no 2988 0.110950711917695 4263 1547771 SGTC_3282 9108498 15.4605 µM -1.22293245623453 0.10754100557125 no 2989 0.110677604304454 4277 16459645 SGTC_628 1636-0253 16 µM -1.22311259004874 0.107505821149956 no 2990 0.110643586998002 4300 4456143 SGTC_2123 5259487 200 µM -1.22560536054697 0.107019775271486 no 2991 0.110173609805647 4327 2173474 SGTC_1319 1306-0155 43.7 µM -1.22775382697547 0.106602135988645 no 2992 0.109769696716664 4350 3122360 SGTC_3312 9133330 71.43 µM -1.22985051098862 0.10619569816078 no 2993 0.109376544636552 4339 17617324 SGTC_2090 5301565 104.445 µM -1.23255445527214 0.105673198383059 no 2994 0.108871019037386 4304 2056344 SGTC_1682 st012968 530 nM -1.23298090981617 0.105590961932339 no 2995 0.108791443305277 4317 24207270 SGTC_2228 7354201 200 µM -1.23344886965876 0.10550077496525 no 2996 0.108704170886639 4389 753451 SGTC_3267 9137951 49.47 µM -1.24194683394169 0.103872697082719 no 2997 0.107128089360696 4355 16643986 SGTC_170 4197-0004 226 µM -1.24424081670764 0.103436345655248 no 2998 0.106705472821122 4317 218692 SGTC_1563 conessine 56.1 µM -1.24589914104209 0.103121736026613 no 2999 0.106400712742941 4407 441082 An anti-amoebic, histamine inhibitor. SGTC_1362 1611-0397 101 µM -1.24783871321714 0.10275465180135 no 3000 0.106045064133084 4294 27816 SGTC_2951 9072950 58.06 µM -1.24836388528536 0.102655421091693 no 3001 0.105948914178038 4264 16488155 SGTC_257 daunorubicin 18.5 µM -1.24946471113348 0.102447647260385 no 3002 0.105747576400872 4349 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_1547 harmine 94.2 µM -1.24958818726799 0.10242436101663 no 3003 0.105725010246535 4266 5280953 A monoamine oxidase inhibitor YHR072W ERG7 SGTC_45 0kpi-0036 14.9 µM -1.25155121140236 0.102054673051045 no 3004 0.105366720946854 4347 2795021 SGTC_830 4076-0286 57.8 µM -1.25231528967958 0.10191104025725 no 3005 0.105227499850637 4396 6866659 SGTC_495 decylubiquinone 155 µM -1.25910577931754 0.100641011573731 no 3006 0.103996063623693 4342 2971 A Co-enzyme Q analog. A free radical scavenger. SGTC_1741 st038134 10.228 µM -1.26181674180743 0.100137216635727 no 3007 0.103507368236382 4390 1272587 SGTC_3159 9100096 49.47 µM -1.26224009203043 0.100058709345442 no 3008 0.10343120313311 4278 25236875 SGTC_1582 3',3',6'-trihydroxyflavone 74 µM -1.26374527810862 0.0997799472328354 no 3009 0.103160733975667 4324 688803 SGTC_551 k048-0028 34.9 µM -1.27083841979088 0.0984739240862412 no 3010 0.101893068781115 4311 6836383 SGTC_3354 9151612 71.43 µM -1.27308289462934 0.0980632790317631 no 3011 0.10149431406248 4346 27261949 SGTC_1965 Pectolinarigenin 58.4 µM -1.2748731463344 0.0977366384239025 no 3012 0.101177072643543 4333 5320438 An anti-inflammatory. SGTC_2972 9093619 59.92 µM -1.27501074986087 0.0977115650050872 no 3013 0.10115271856005 4296 25236256 SGTC_8 0354-0001 70 µM -1.2762551021748 0.0974850395390967 no 3014 0.100932677917084 4328 4993152 SGTC_1592 4',5'-dihydroxyflavone 8.85 µM -1.27627720524658 0.0974810193170712 no 3015 0.10092877255535 4342 688669 SGTC_120 rhodamine 6G 52.259 µM -1.27965437879072 0.0968681891992074 no 3016 0.10033335800036 4361 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase SGTC_1060 3448-7350 82 µM -1.28124204108706 0.0965810676231565 no 3017 0.10005433180035 4281 570178 SGTC_2622 2-methoxyxanthone 59.94 µM -1.28241896067661 0.0963686308579619 no 3018 0.0998478581972506 4325 71034 A hepatoprotective. SGTC_3322 9139058 2.11 µM -1.28621517680535 0.0956857452300701 no 3019 0.0991839879070722 4401 4908926 YPR165W RHO1 SGTC_2062 5245942 200 µM -1.28741502791291 0.0954706512187474 no 3020 0.0989748345595021 4400 1376160 SGTC_2121 5257820 149.641 µM -1.28880191389422 0.0952224716459497 no 3021 0.098733480250692 4388 791256 SGTC_2170 morpholine 200 µM -1.28969439821437 0.0950630153549322 no 3022 0.0985783926644474 4394 121171 Reacts with secondary amines. SGTC_1933 st074711 15.9 µM -1.29066132490319 0.0948904808306413 no 3023 0.0984105705266453 4334 17250958 SGTC_614 0462-0418 107 µM -1.29152440026297 0.0947366720948698 no 3024 0.0982609498740836 4123 5188303 SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM -1.29370147931738 0.0943495110550603 no 3025 0.0978842770887102 4384 688788 SGTC_970 1315-0089 19.5 µM -1.29386934806511 0.094319706627562 no 3026 0.0978552768654145 4322 6811083 YLR033W RSC58 SGTC_1493 4348-0038 111 µM -1.29466949049529 0.0941777399484957 no 3027 0.0977171345300215 4331 800424 SGTC_208 k072-0098 12.366 µM -1.29570121056582 0.0939949179475877 no 3028 0.0975392220737707 4340 5948901 SGTC_177 1327-0068 8.361 µM -1.29857275366824 0.0934874561921214 no 3029 0.0970452967413945 4343 15389900 YOR207C | YLR033W RET1 | RSC58 SGTC_149 3970-0822 46.1 µM -1.30386188732318 0.0925580565538361 no 3030 0.0961403385382221 4354 3114250 YBL034C STU1 SGTC_1940 st075990 51.1 µM -1.30403986493531 0.0925269018626349 no 3031 0.0961099952516774 4430 1084979 SGTC_2719 novobiocin 32.65 µM -1.3054913530405 0.0922731108209489 no 3032 0.0958627948204961 4420 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication. SGTC_3286 9117135 37.221 µM -1.3063191212425 0.0921286073854866 no 3033 0.0957220286133781 4328 3438150 SGTC_2366 9070441 60.58 µM -1.30665429520788 0.0920701437671007 no 3034 0.0956650738454664 4337 6837235 SGTC_493 zm226600 134 µM -1.3071182237848 0.0919892671102984 no 3035 0.0955862814697875 4392 5240098 A potassium channel opener. YCR052W RSC6 SGTC_192 3455-0609 60.9 µM -1.30745585233887 0.0919304414164385 no 3036 0.0955289695796491 4437 3769639 SGTC_1268 0828-0275 2.46 µM -1.30770194469568 0.0918875818129154 no 3037 0.0954872117454028 4429 745337 SGTC_2218 6965428 192.983 µM -1.30809701928494 0.0918188063209625 no 3038 0.0954202021700723 4270 675684 SGTC_1719 st032227 49.2 µM -1.30885338097215 0.0916872435313887 no 3039 0.0952920103811966 4366 3125804 SGTC_353 1988-1175 58.3 µM -1.30901404205666 0.0916593158725963 no 3040 0.0952647971085821 4204 2788357 SGTC_2459 5811157 9.22 µM -1.30951795066353 0.0915717625066855 no 3041 0.0951794806260658 4321 2870684 YBR192W RIM2 SGTC_3314 9135860 59.4275 µM -1.31149583133784 0.0912287076935465 no 3042 0.0948451505983735 4363 25252478 SGTC_1364 1653-0028 37.6 µM -1.31165648628975 0.0912008846915979 no 3043 0.0948180324179674 4363 5718652 SGTC_1906 st060206 94.7 µM -1.31658550811493 0.0903503080513046 no 3044 0.0939887995320276 4405 5133468 SGTC_3154 9100113 49.47 µM -1.31731908426558 0.0902242237596148 no 3045 0.0938658454193104 4375 25237525 SGTC_734 2023-0417 80 µM -1.31802060864494 0.0901037707025345 no 3046 0.0937483745688173 4392 3935732 SGTC_1447 4239-0816 81.9 µM -1.31813289449894 0.090084502106808 no 3047 0.0937295822879507 4380 1341554 SGTC_2952 9073731 13.78 µM -1.32389670979065 0.0890995210482022 no 3048 0.0927686755514635 4392 16457353 SGTC_1607 st000305 50.6 µM -1.32437283215198 0.0890185160854092 no 3049 0.0926896263935606 4390 5457690 SGTC_1785 bathophenanthroline 24 µM -1.32735645072856 0.0885121465551052 no 3050 0.0921953991816925 4303 72812 An iron chelator. SGTC_225 nsc-122657 1.016 µM -1.33001647379394 0.0880625087126623 no 3051 0.091756421791887 4393 275685 SGTC_661 1304-0007 33.6 µM -1.33946284855139 0.0864794977241074 no 3052 0.0902100205757146 4404 3117130 SGTC_748 act1.228 77.9 µM -1.34042992253569 0.0863186449792914 no 3053 0.0900528065117606 4368 4421505 YNR035C ARC35 SGTC_2036 5160441 105 µM -1.34251882191616 0.0859719635702858 no 3054 0.0897139158713999 4361 134534 YIL048W NEO1 SGTC_861 0443-0273 110 µM -1.3449810166736 0.0855646677599049 no 3055 0.0893156825148332 4392 6149169 SGTC_1163 k060-0048 49.9 µM -1.34814303792931 0.0850437282696347 no 3056 0.0888061906432185 4402 6809982 SGTC_603 3794-0023 45.9 µM -1.35124479938993 0.0845350296713441 no 3057 0.0883085140766289 4428 3802260 SGTC_803 4488-1585 147 µM -1.35254279538666 0.084322833021877 no 3058 0.0881008690709278 4402 747204 SGTC_1109 tnp00067 928.257 nM -1.35435120060321 0.0840278613033548 no 3059 0.087812179248775 4406 676295 SGTC_2875 9039966 71.43 µM -1.35556765454853 0.0838298799390719 no 3060 0.0876183845594331 4391 6463691 SGTC_1286 0929-0070 131 µM -1.35841111620362 0.0833684653387946 no 3061 0.087166634466227 4469 1420408 SGTC_1249 0481-0015 10.2 µM -1.36041959850892 0.0830436968957253 no 3062 0.0868485900024276 4342 4227577 SGTC_3001 9076041 71.4286 µM -1.36385312363894 0.0824907063860885 no 3063 0.0863068983671081 4411 16004211 SGTC_848 0368-0089 85.6 µM -1.36483102642778 0.0823337174213112 no 3064 0.0861530823614823 4395 762535 SGTC_810 3825-7150 143 µM -1.36901571950756 0.0816644625649213 no 3065 0.0854971806230368 4453 22330411 YGL099W LSG1 SGTC_2136 5328288 199.296 µM -1.37635903245337 0.0804999775769113 no 3066 0.0843552524273483 4395 262395 SGTC_1068 loratadine 26.9 µM -1.37838936515831 0.0801802364747449 no 3067 0.0840415525476239 4471 3957 A H1 histamine antagonist. SGTC_3192 9110362 49.47 µM -1.37879087333915 0.0801171199558888 no 3068 0.0839796207325329 4412 16649480 SGTC_676 falcarinol 140 µM -1.38099277521709 0.0797716516981717 no 3069 0.0836405910434556 4448 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer. SGTC_3311 9131146 2.8755 µM -1.38444651998982 0.0792320465415908 no 3070 0.0831108864550284 4368 4900406 YPR165W RHO1 SGTC_1224 0823-0416 294 µM -1.38547002906546 0.0790726678523156 no 3071 0.0829543953661776 4449 3598164 SGTC_1026 k007-1105 30.6 µM -1.38732557420947 0.078784345500262 no 3072 0.08267125409149 4388 7066794 SGTC_1182 1222-0449 220 µM -1.38812890204948 0.0786597684318949 no 3073 0.0825488985663191 4430 658318 SGTC_2963 9082507 9 µM -1.38850370817532 0.0786016960039355 no 3074 0.0824918581950392 4438 16459611 SGTC_3101 9120531 49.47 µM -1.38863934737104 0.0785806880886148 no 3075 0.0824712230764246 4421 24824904 SGTC_146 3448-8650 53.125 µM -1.39159611441224 0.0781237983261758 no 3076 0.0820223680798063 4408 2891488 YIL048W NEO1 SGTC_2534 helenine 20.12 µM -1.39252933914938 0.0779800124271179 no 3077 0.0818810817935563 4440 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58 SGTC_250 brefeldin a 552.239 µM -1.3951131928006 0.0775829547581222 no 3078 0.0814908542183625 4344 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.  SGTC_2794 7785382 27.27 µM -1.39678875307365 0.0773262951149474 no 3079 0.0812385526938588 4428 2205081 SGTC_630 4356-0227 183 µM -1.39928110413264 0.0769457146928346 no 3080 0.0808643518655341 4388 779312 SGTC_2450 5739737 12.93 µM -1.39975090113984 0.0768741367438229 no 3081 0.0807939626786031 4461 2262825 SGTC_2115 tiliquinol 12.7705 µM -1.40817950486021 0.0755985454690939 no 3082 0.0795389617383372 4425 71208 A bioactive hydroxyquinoline. SGTC_1458 k015-0034 6.33 µM -1.41027266548434 0.0752842787653364 no 3083 0.0792295932670447 4471 3598957 SGTC_1549 4'-methoxyflavonol 74.6 µM -1.4141780134235 0.0747005945179413 no 3084 0.0786548209148052 4391 97141 SGTC_2779 methotrexate 400 µM -1.41448819447489 0.0746543840210502 no 3085 0.0786093056131248 4446 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2 SGTC_1209 2323-2347 50.3 µM -1.41655599225504 0.0743468826534246 no 3086 0.0783063913841253 4459 5412760 SGTC_1380 2291-0730 164 µM -1.41696774784604 0.0742857662766081 no 3087 0.0782461786221195 4435 2999191 SGTC_1128 3448-9350 235 µM -1.42336264696214 0.073341497405942 no 3088 0.0773155274334626 4456 619386 SGTC_597 k018-0003 82.8 µM -1.42676462971093 0.0728429171914402 no 3089 0.0768238747795102 4502 6786234 SGTC_2932 9016711 44.54 µM -1.42903069283544 0.0725122551655109 no 3090 0.0764977059523677 4437 7117328 SGTC_2372 9071633 200 µM -1.43235451811468 0.0720293271183079 no 3091 0.0760211939677116 4493 21321366 SGTC_25 0118-0223 35.662 µM -1.43325688481271 0.0718986462202296 no 3092 0.0758922192511211 4443 5333628 SGTC_474 dl-dihydrosphingosine 5 µM -1.43370054013026 0.0718344626875833 no 3093 0.075828869003533 4448 3058739 A sphingolipid protein kinase C inhibitor. SGTC_930 2810-3379 265 µM -1.43966728439442 0.0709755188816809 no 3094 0.0749807767481463 4464 1015764 SGTC_2164 5685496 200 µM -1.44013221174425 0.0709089228965513 no 3095 0.0749149986458776 4375 759046 SGTC_3332 9141069 11.198 µM -1.44028427122732 0.0708871523843892 no 3096 0.0748934947664218 4393 17332883 SGTC_889 0919-1524 82.7 µM -1.4403758820454 0.0708740388484042 no 3097 0.0748805416621908 4472 3905452 SGTC_3276 9139060 49.47 µM -1.44777990469277 0.0698203472404208 no 3098 0.0738393072768044 4560 4870619 SGTC_1984 st072354 53.1 µM -1.44893477182861 0.0696570867914258 no 3099 0.0736778997126562 4338 5762938 SGTC_2426 5582046 32.21 µM -1.44966438049021 0.0695540955725427 no 3100 0.0735760666154807 4456 2251934 SGTC_1277 0873-0036 22 µM -1.4521806178285 0.0691998040197628 no 3101 0.0732256952437525 4543 5965735 SGTC_1534 6-azauridine 81.6 µM -1.45354048161753 0.0690089119664255 no 3102 0.0730368742425897 4490 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1 SGTC_1003 4049-0218 100 µM -1.45819796271614 0.0683581885595605 no 3103 0.0723929925984237 4472 295161 SGTC_1867 st057372 64 µM -1.4583563924681 0.0683361369844867 no 3104 0.0723711669329116 4436 688837 SGTC_928 2764-0428 58.7 µM -1.46112951011741 0.0679510396560709 no 3105 0.0719899515371207 4492 662578 SGTC_477 mead ethanolamide 10 µM -1.46164013395511 0.0678803133809659 no 3106 0.0719199251682355 4472 16061185 SGTC_2234 tolnaftate 200 µM -1.46173742603602 0.0678668439493987 no 3107 0.0719065885697756 4582 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7 SGTC_1770 st043884 66.3 µM -1.46463936566647 0.0674660382301418 no 3108 0.0715096679316486 4483 670149 SGTC_3027 9089541 49.47 µM -1.46513661779001 0.0673975434723172 no 3109 0.0714418239790904 4465 9943819 SGTC_1190 1486-1332 13 µM -1.46569557844039 0.0673206127595467 no 3110 0.071365619641165 4467 4150046 SGTC_1258 0671-0043 57.1 µM -1.46602814450385 0.0672748733408161 no 3111 0.0713203097887673 4473 4298767 SGTC_1157 4092-0394 27.6 µM -1.46977919923611 0.0667606349416295 no 3112 0.0708107822559017 4536 3659885 SGTC_999 SEC7.066 22.7 µM -1.47183149228916 0.0664805728082341 no 3113 0.070533193562536 4426 740511 YDR170C SEC7 SGTC_1203 3992-3522 103 µM -1.47285204469649 0.0663416441595287 no 3114 0.0703954676304122 4534 5322312 SGTC_3243 9134147 49.47 µM -1.47454730440245 0.0661113640766698 no 3115 0.0701671455036166 4570 24282180 SGTC_2544 sphondin 68.51 µM -1.47486781737874 0.0660678960354545 no 3116 0.0701240420536331 4439 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31 SGTC_1485 3909-9022 254 µM -1.47517307350811 0.0660265177203882 no 3117 0.0700830093250356 4538 714516 SGTC_1985 st071382 65.5 µM -1.4766831682938 0.0658221154744305 no 3118 0.0698802930443109 4470 6123237 SGTC_2487 5918373 44.05 µM -1.47879434167079 0.0655371754482085 no 3119 0.069597644298072 4535 2876279 SGTC_2457 5731572 11.68 µM -1.48172369534933 0.0651433931289182 no 3120 0.0692069147600979 4526 2865357 SGTC_950 1165-0508 94.1 µM -1.48201168041693 0.0651047796837372 no 3121 0.0691685935251848 4463 6148369 SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM -1.48267795358172 0.0650155129206079 no 3122 0.0690799973971969 4493 616764 SGTC_259 usnic acid 108.925 µM -1.4851230714266 0.0646887317747857 no 3123 0.0687556127482431 4528 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_2182 6325192 200 µM -1.48538679032875 0.0646535630422385 no 3124 0.068720696435398 4519 736248 SGTC_121 0557-0495 61.343 µM -1.49155759698541 0.0638348754297213 no 3125 0.0679075806583271 4522 3104427 SGTC_1459 k035-0031 35.7 µM -1.49164672418949 0.063823110174648 no 3126 0.0678958911984201 4221 3877128 YMR208W ERG12 SGTC_2639 lactacystin 53 µM -1.49221921415952 0.0637475787237509 no 3127 0.0678208434387136 4509 3870 A proteasome inhibitor. SGTC_2385 9074692 200 µM -1.49227374540583 0.0637403877737551 no 3128 0.0678136982762233 4495 17046906 SGTC_2239 6685329 187.64 µM -1.4924764083724 0.0637136684562774 no 3129 0.0677871486911374 4514 805680 SGTC_1857 st056007 79.3 µM -1.49253123265362 0.0637064418579159 no 3130 0.0677799678909508 4472 619834 SGTC_2213 7173844 200 µM -1.49290902466541 0.0636566609826084 no 3131 0.0677305012464647 4501 892728 SGTC_677 0929-0063 136 µM -1.50141545957299 0.0625437796204835 no 3132 0.0666240688905406 4523 1539583 SGTC_2546 rhodinyl acetate 100 µM -1.50317745835715 0.0623151681191047 no 3133 0.0663966443665791 4451 6708682 SGTC_2556 citropten 84.59 µM -1.50430574937351 0.0621691199923502 no 3134 0.0662513296978712 4497 2775 A potential DNA crosslinker. SGTC_758 0868-0029 16 µM -1.50566715128169 0.0619932531786529 no 3135 0.0660763202921792 4451 762687 SGTC_1159 4092-0538 61.2 µM -1.51166283543212 0.0612233425699284 no 3136 0.0653098288540418 4526 717301 SGTC_3088 9117578 49.47 µM -1.51261557424561 0.0611016915516833 no 3137 0.0651886679041081 4564 678341 SGTC_2166 5933061 31.504 µM -1.5126632331896 0.0610956111564682 no 3138 0.0651826116419861 4529 2877375 SGTC_2911 7942208 15.64 µM -1.51357345023823 0.0609795751257904 no 3139 0.0650670295489923 4514 1243384 SGTC_1848 st056003 16.4 µM -1.51528015838799 0.0607624654959807 no 3140 0.0648507354423108 4510 146492 SGTC_1925 st057770 10.1 µM -1.51701180188079 0.0605428021532647 no 3141 0.0646318521786867 4498 5989122 SGTC_2356 9061756 188.97 µM -1.51912526623011 0.0602755462908214 no 3142 0.064365484015404 4543 20104043 SGTC_1223 0764-0573 147 µM -1.52034457340939 0.0601217806850678 no 3143 0.0642121984648778 4497 1609797 SGTC_178 4092-0806 87.505 µM -1.52461606080754 0.0595855291637174 no 3144 0.0636774445370407 4394 2169044 SGTC_1777 st045864 34.765 µM -1.52592431205139 0.0594220405531792 no 3145 0.0635143575719637 4521 4691462 SGTC_1724 st037281 8.293 µM -1.53807449597732 0.0579204144530151 no 3146 0.0620152005375893 4464 574124 YDL195W SEC31 SGTC_2181 6316240 54.2555 µM -1.53890231897568 0.0578192001650636 no 3147 0.0619140724833738 4524 12779990 SGTC_3274 9138298 49.47 µM -1.54020722825958 0.0576599370359411 no 3148 0.0617549242717504 4486 17015756 SGTC_2837 9008476 45.46 µM -1.54299332808578 0.0573210505193527 no 3149 0.0614161973682751 4476 2992805 SGTC_3245 9134821 49.47 µM -1.54645617780965 0.0569020344868133 no 3150 0.0609972178539616 4519 17014901 SGTC_2597 laccaic acid a 100 µM -1.54763674663642 0.0567597344455211 no 3151 0.0608548894875608 4497 5491415 A textile dye. SGTC_1002 4049-0206 172 µM -1.54798067255781 0.0567183320492009 no 3152 0.060813474954378 4480 4662749 SGTC_70 0141-0289 43.283 µM -1.55407866529442 0.0559881884467359 no 3153 0.0600828267697943 4476 352408 SGTC_2486 5283202 22.39 µM -1.55611116476145 0.0557464810903319 no 3154 0.0598408302868531 4526 1377751 SGTC_1187 1391-0724 117 µM -1.55636667434695 0.0557161539252419 no 3155 0.0598104625241342 4574 6997986 SGTC_2147 5545932 89.7195 µM -1.56255413851943 0.0549857137516245 no 3156 0.0590787512602397 4568 797404 SGTC_825 1988-2224 89.6 µM -1.58106708802137 0.052845353805865 no 3157 0.0569313495056361 4523 1180859 SGTC_2801 7907800 81.82 µM -1.58768939054912 0.0520959693825414 no 3158 0.0561782966443768 4520 6620925 SGTC_2227 7312221 64.1025 µM -1.59113612399063 0.0517092883230444 no 3159 0.0557894721779166 4643 887188 YOR168W | YOR169C GLN4 | YOR169C SGTC_2270 7924575 90.91 µM -1.59373325363245 0.0514194323724096 no 3160 0.0554978964061017 4513 1262135 SGTC_3006 9075424 71.4286 µM -1.6013678579606 0.050574840629354 no 3161 0.0546477337084712 4510 7465181 SGTC_2477 5967686 25.23 µM -1.60362663148311 0.0503270894341228 no 3162 0.0543981884373136 4538 776118 SGTC_1081 sertraline 6 µM -1.60665178454078 0.0499967949328214 no 3163 0.0540653879756551 4545 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1 SGTC_3285 9112818 20.8695 µM -1.61088932024315 0.0495370383069668 no 3164 0.0536019240800185 4539 17017947 YPR165W RHO1 SGTC_1633 st005664 67.9 µM -1.61625548134737 0.0489596790213131 no 3165 0.0530195438805019 4531 2063822 SGTC_2780 5215298 71.43 µM -1.62007716993724 0.0485517810619827 no 3166 0.0526078504522592 4568 2834131 SGTC_1308 1187-1617 41.4 µM -1.62135563667488 0.048415935364762 no 3167 0.052470694649606 4580 2882570 SGTC_2044 5102272 200 µM -1.62669223650482 0.0478521653296904 no 3168 0.0519012392130344 4564 592666 SGTC_1628 st004252 77.7 µM -1.62819107231078 0.0476947739653377 no 3169 0.0517421886102264 4549 692968 SGTC_2247 cerulenin 830 nM -1.62850012661952 0.0476623720696843 no 3170 0.0517094412028251 4576 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12 SGTC_665 3914-0008 307 µM -1.62873051100256 0.047638229563578 no 3171 0.0516850403840844 4537 1069549 SGTC_1993 st073995 70.8 µM -1.63257153487587 0.047237160967709 no 3172 0.0512795710073032 4565 3098394 SGTC_375 3970-0961 9.27 µM -1.6327483271192 0.0472187661843947 no 3173 0.0512609694087556 4535 2898222 SGTC_277 nystatin 15.5 µM -1.63433519813118 0.047053913234102 no 3174 0.0510942434104788 4584 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_2790 5423970 71.43 µM -1.63607051776453 0.046874167195269 no 3175 0.0509124148285659 4564 1376240 YKL165C | YIL048W MCD4 | NEO1 SGTC_3017 9080681 49.47 µM -1.63651250991132 0.0468284733419453 no 3176 0.0508661848425365 4576 16451914 SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM -1.63732827993815 0.0467442315681482 no 3177 0.0507809474847781 4638 16725076 SGTC_1199 1638-0010 4.46 µM -1.6395771095119 0.0465126320685134 no 3178 0.0505465628801249 4549 3111136 SGTC_1634 st006576 41 µM -1.63989520052402 0.046479947405804 no 3179 0.0505134794787237 4541 3915356 SGTC_1564 D-Arginine 115 µM -1.64382238973972 0.0460779356158544 no 3180 0.0501064475458186 4556 71070 D-isomer of arginine; arginine decarboxylase inhibitor. SGTC_533 1222-0222 6.71 µM -1.64459312840011 0.0459993667748986 no 3181 0.050026872441375 4584 3982874 SGTC_1692 fluoroquinolonic acid 71 µM -1.650524764544 0.0453982933581863 no 3182 0.0494178262561306 4586 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2 SGTC_3000 9075062 71.4286 µM -1.65128781335174 0.0453214316353871 no 3183 0.0493399097578296 4550 17057871 SGTC_2053 5265679 138 µM -1.65553704025216 0.0448953206170631 no 3184 0.0489078046844011 4490 764595 SGTC_129 0088-0017 176.636 µM -1.65837224444466 0.0446128055208126 no 3185 0.0486211776189783 4422 182446 SGTC_2272 7805186 180 µM -1.65983915265057 0.0444671979465725 no 3186 0.0484734074775523 4572 2956062 YPR165W RHO1 SGTC_230 MPP+ 141.667 µM -1.66728092521533 0.0437344044545713 no 3187 0.0477292788614785 4550 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death. SGTC_1229 0139-0193 12.2 µM -1.67484979038871 0.0429991217705041 no 3188 0.0469818534962137 4626 3090752 SGTC_319 1348-1596 45.5 µM -1.67557129304091 0.0429295554379189 no 3189 0.046911097847019 4630 5380505 SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM -1.68334113251852 0.0421861465312165 no 3190 0.0461545360296307 4555 521171 SGTC_2795 7780010 54.55 µM -1.68858806438981 0.0416900446741864 no 3191 0.0456491997813151 4545 953673 SGTC_3113 9123498 49.47 µM -1.68984914218704 0.0415715157818502 no 3192 0.0455284097362505 4670 8897275 SGTC_3065 9113888 49.47 µM -1.70232910325524 0.0404131831177238 no 3193 0.0443468460335236 4604 16648368 SGTC_311 1315-0136 58 µM -1.71238568385375 0.0394989649940842 no 3194 0.0434128077863959 4606 6759207 SGTC_878 0828-0289 13.7 µM -1.72009382966348 0.0388096853186853 no 3195 0.042707693584794 4571 745350 YLR208W SEC13 SGTC_1147 3809-1045 12.3 µM -1.72127162484103 0.0387052323054126 no 3196 0.0426007729816598 4614 325925 SGTC_1195 1502-0147 41.1 µM -1.72811807682536 0.0381025798442878 no 3197 0.0419835286175071 4616 817940 SGTC_1080 nisoldipine 24.4 µM -1.73201064185213 0.0377633674188309 no 3198 0.0416358338497933 4621 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class. SGTC_222 nsc-310342 10.666 µM -1.73514398030477 0.0374921108862018 no 3199 0.041357652996448 4621 432556 SGTC_1127 asiatic acid 681.4 nM -1.73730803580866 0.0373056968278829 no 3200 0.0411664069552752 4550 470603 A kinase inhibitor which arrests cells at G2/M. SGTC_291 SEC14.278 35.5 µM -1.74386551034116 0.0367454479119692 no 3201 0.0405912719678546 4618 1068044 SGTC_2600 tangeritin 87.95 µM -1.749942645235 0.0362323993091154 no 3202 0.0400641055275068 4534 68077 A bioactive flavone. SGTC_365 0121-0052 13.6 µM -1.7525188180988 0.0360166887994948 no 3203 0.0398423184766722 4586 3101739 SGTC_1756 st041558 35.5 µM -1.75840382301187 0.0355278645421079 no 3204 0.0393394115576806 4672 3955792 SGTC_462 ag-879 158 µM -1.76420627210738 0.0350512361153594 no 3205 0.0388486285719528 4610 6809654 Ag-879 is a 5-Lipoxygenase inhibitor. SGTC_1013 4112-3890 241 µM -1.7735815833199 0.034292221276957 no 3206 0.0380661931067915 4601 705171 SGTC_1674 st016616 23.6 µM -1.78625359931129 0.0332878294769302 no 3207 0.0370291030654798 4586 625830 SGTC_3130 9127414 49.47 µM -1.78716640282619 0.0332164254632925 no 3208 0.0369552988479436 4651 1494646 SGTC_274 sirtinol 40.1 µM -1.79135922667143 0.0328900609028224 no 3209 0.0366178337458097 4654 6836442 NAD-dependent acetyltransferase inhibitor. SGTC_6 0844-0013 19.835 µM -1.79351435506084 0.0327233393791486 no 3210 0.036445358685411 4703 1584900 SGTC_2750 bromebric acid 70.15 µM -1.79438487263033 0.0326561936954426 no 3211 0.0363758798714817 4611 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2 SGTC_1612 st002233 45.4 µM -1.79976144956875 0.0322439955405214 no 3212 0.0359491567511216 4643 1035021 SGTC_965 1291-5240 308 µM -1.80770094377394 0.0316431706909515 no 3213 0.0353265288190613 4618 2834598 SGTC_1627 st003713 25.6 µM -1.81046433016921 0.031436232941941 no 3214 0.0351119055278002 4632 16195070 YER133W GLC7 SGTC_573 3702-0553 84.7 µM -1.8121834415065 0.0313080617591307 no 3215 0.0349789283643783 4596 1222756 SGTC_2729 fluphenazine 10.66 µM -1.81610188852394 0.0310175300826465 no 3216 0.0346773720397801 4603 3372 An atypical antipsychotic. SGTC_1690 st023502 41.2 µM -1.81735405117733 0.0309251606875175 no 3217 0.0345814593000527 4637 24207482 SGTC_218 alverine citrate 93.75 µM -1.81825753614132 0.030858653999877 no 3218 0.0345123898817387 4673 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_2425 5628681 7.85 µM -1.82035986725116 0.0307043568770733 no 3219 0.0343521099473346 4655 5714958 SGTC_64 000l-0018 272.079 µM -1.82235127051258 0.0305587908064692 no 3220 0.0342008517003022 4549 6811119 SGTC_487 nimodipine 119 µM -1.82672473423924 0.0302411082162954 no 3221 0.0338705836987588 4653 4497 L-type voltage-gated calcium channels inhibitor SGTC_566 0958-0068 16.5 µM -1.83493958864286 0.0296517913288486 no 3222 0.0332573205123425 4548 6815365 SGTC_158 k038-0087 26.446 µM -1.83732867384019 0.0294822030433297 no 3223 0.0330806946778171 4550 X158 SGTC_2206 7254556 146.969 µM -1.84353094058665 0.0290456929247148 no 3224 0.0326257642670462 4657 4398905 SGTC_354 2783-3500 4.88 µM -1.85077877383333 0.0285424150033905 no 3225 0.0321006929719777 4628 6740761 SGTC_561 1550-0330 72.9 µM -1.85479422767102 0.0282667250546475 no 3226 0.0318128083309013 4622 6812934 SGTC_1707 st032323 6.317 µM -1.85700984403452 0.028115558213162 no 3227 0.0316548767834548 4453 3132057 YMR211W DML1 SGTC_3313 9133968 57.047 µM -1.85854943837866 0.0280109117875624 no 3228 0.0315455147967311 4632 1494643 SGTC_2758 dehydroepiandrosterone 69.35 µM -1.87400736262742 0.0269781016572683 no 3229 0.0304647051626177 4606 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem] SGTC_777 1315-0167 517 µM -1.87630995464311 0.026827010245965 no 3230 0.0303063654577463 4668 4221767 SGTC_3315 9136395 68.55 µM -1.8799146287737 0.0265918980530783 no 3231 0.0300598569278685 4655 16876844 SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM -1.88004224170431 0.026583606243283 no 3232 0.0300511605751252 4685 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair. SGTC_1043 0916-0009 19.3 µM -1.88157398021534 0.0264842480676809 no 3233 0.0299469409147491 4657 3101130 SGTC_3223 9129970 49.47 µM -1.88546460573218 0.0262332719640962 no 3234 0.0296835693483693 4650 17248386 SGTC_3216 9129716 49.47 µM -1.88915256202265 0.0259972084504232 no 3235 0.0294356945419056 4567 8056934 SGTC_1141 3253-0389 52.6 µM -1.89104040279684 0.0258770583249197 no 3236 0.0293094755410997 4649 5402031 SGTC_1300 1094-0077 113 µM -1.89291392392529 0.0257582792665348 no 3237 0.0291846586307406 4647 5532636 SGTC_1830 st055982 50.3 µM -1.89527543148146 0.0256092128363128 no 3238 0.0290279606547109 4646 455313 An antimicrobial agent. SGTC_1488 4013-0813 75.9 µM -1.89733950020605 0.0254795139323088 no 3239 0.0288915724388139 4689 2910057 SGTC_2763 lisinopril 49.32 µM -1.90110287752236 0.0252444522038522 no 3240 0.0286442693910006 4583 5362119 A lysine-analog of enalapril and an ACE inhibitor. SGTC_1016 4226-1401 38 µM -1.90405518461092 0.0250613244674426 no 3241 0.0284514987408449 4657 2901613 SGTC_200 k038-0079 37.545 µM -1.90620049305261 0.0249289535032834 no 3242 0.0283120991523178 4672 3436683 SGTC_1504 k297-0033 30 µM -1.90762658828288 0.0248412846036775 no 3243 0.0282197480683163 4594 4388117 SGTC_2383 9036125 200 µM -1.91189133335162 0.0245806518061224 no 3244 0.0279450667690132 4625 79580 SGTC_1790 st045711 43.5 µM -1.91439318018999 0.0244288263291919 no 3245 0.0277849681511974 4653 585119 SGTC_746 1095-0025 46.6 µM -1.93332104006326 0.0233054999099601 no 3246 0.0265983307397993 4669 6749286 SGTC_2157 5649910 96.377 µM -1.93586098355343 0.0231581212516772 no 3247 0.0264423647258296 4650 2858091 SGTC_1417 3966-0327 90.4 µM -1.93970837621455 0.0229363736345888 no 3248 0.0262075705224478 4720 651118 SGTC_783 0848-0141 92.7 µM -1.9434644531661 0.0227216172113483 no 3249 0.025980033145344 4626 6755076 YHR007C | YLR033W ERG11 | RSC58 SGTC_449 xestospongin c 11.1929 µM -1.94750736890203 0.0224923568342127 no 3250 0.0257369685880587 4680 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1 SGTC_1937 st074714 47.2 µM -1.96073682221084 0.0217557484020315 no 3251 0.0249548656447784 4635 17250970 SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM -1.96217864564046 0.0216767140889564 no 3252 0.0248708445954639 4635 6857784 SGTC_876 0720-0963 56.8 µM -1.96435759341727 0.0215577343013011 no 3253 0.0247443185038186 4679 765861 SGTC_2689 tacrolimus 100 µM -1.96474483967462 0.0215366468786243 no 3254 0.0247218886785594 4650 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). SGTC_443 clozapine 122 µM -1.97164687727245 0.0211637123708612 no 3255 0.0243249659380733 4672 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_2226 7298446 200 µM -1.98477249630497 0.0204695641919881 no 3256 0.0235848944050772 4694 3283010 SGTC_2909 7941780 10.49 µM -1.98676969750275 0.0203656521997689 no 3257 0.0234739620491288 4650 1243215 SGTC_1363 1636-0063 10.4 µM -1.99868723686155 0.0197548473077334 no 3258 0.0228211024050866 4696 6072185 SGTC_1436 4092-1007 8.32 µM -2.00274431355018 0.0195504912495865 no 3259 0.0226023698693364 4695 2881121 SGTC_2155 5570423 76 µM -2.00546629142803 0.0194143931616931 no 3260 0.0224566104540102 4688 797402 SGTC_749 1000-0129 128 µM -2.01174785315744 0.0191033861349301 no 3261 0.0221232617231271 4701 708470 SGTC_2391 6285546 200 µM -2.01395365320313 0.018995184187478 no 3262 0.0220071998355143 4693 846083 SGTC_3295 9122362 53.5725 µM -2.02025376770431 0.01868900842569 no 3263 0.021678535839732 4680 4730473 SGTC_2498 4'-Methoxychalcone 54.63 µM -2.02895228398991 0.0182731848013537 no 3264 0.0212315753150654 4681 641818 YHR062C RPP1 SGTC_1394 3474-0001 65.7 µM -2.03043612668583 0.0182030441235783 no 3265 0.0211561137928013 4691 5017666 YIL048W NEO1 SGTC_3264 9137442 49.47 µM -2.03419218319523 0.0180265214702578 no 3266 0.0209661111882915 4645 17015726 SGTC_2869 9037858 32.47 µM -2.04446986761192 0.0175509466075407 no 3267 0.0204535756167385 4664 27187042 SGTC_2557 derrustone 83.84 µM -2.05717095115874 0.0169780677343633 no 3268 0.0198348923683932 4670 629853 An antioxidant. SGTC_452 diindolylmethane 8 µM -2.05909663786603 0.016892621237383 no 3269 0.0197424909320937 4681 3071 Inhibits expression of several cancer promoting factors. SGTC_1648 st011736 69.8 µM -2.06636271486224 0.0165735147861953 no 3270 0.0193971218744724 4689 2855514 SGTC_1619 st003326 88.7 µM -2.07109339826639 0.0163685405247281 no 3271 0.0191750343423699 4680 2849032 SGTC_203 k066-0004 30.888 µM -2.08714869178354 0.0156889930560931 no 3272 0.018437347883083 4735 6795412 SGTC_623 k072-0108 16.9 µM -2.08799293942347 0.0156539397758122 no 3273 0.0183992357961091 4693 5382803 SGTC_444 curcumin 90.4 µM -2.0930039241666 0.0154472630608063 no 3274 0.018174402127893 4619 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. SGTC_936 3005-4620 401 µM -2.10182915217675 0.0150889624226931 no 3275 0.0177841222377897 4706 777207 SGTC_1466 k213-0079 57.5 µM -2.10780168046147 0.0148505525368997 no 3276 0.0175240737222678 4724 3657981 SGTC_2857 9024691 58.44 µM -2.11037721841753 0.0147487467396788 no 3277 0.0174129385783798 4695 16478292 SGTC_560 2332-1943 155 µM -2.1124589568067 0.0146668990942164 no 3278 0.0173235513771879 4711 21177716 SGTC_1732 st034308 51.822 µM -2.11540829942532 0.0145516090656725 no 3279 0.0171975815243263 4633 830119 SGTC_1623 st003709 20.3 µM -2.12285878111947 0.0142638372132499 no 3280 0.016882843688232 4700 16192618 SGTC_2580 diallyl disulphide 81.36 µM -2.15532827640033 0.0130662362097633 no 3281 0.0155680772904728 4684 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.  SGTC_394 menadione 8.33 µM -2.160289114937 0.0128911368577642 no 3282 0.0153751475473174 4702 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_2117 5521686 200 µM -2.16072448505239 0.0128758672074157 no 3283 0.0153583141779431 4715 803312 SGTC_2256 7954252 200 µM -2.17167710978501 0.012496841689802 no 3284 0.0149400131301471 4725 2972920 SGTC_1970 st070122 35.8 µM -2.18016640259716 0.0122097446546676 no 3285 0.0146225645299883 4714 102928 SGTC_396 dithiazanine 1.25 µM -2.1826508144458 0.0121268136505243 no 3286 0.0145307673200223 4698 10578 An antihelmenthic. SGTC_627 1391-0720 175 µM -2.18646627193559 0.0120004024403322 no 3287 0.0143907548352102 4726 997839 SGTC_3145 9085516 49.47 µM -2.1950267600689 0.011720933264594 no 3288 0.0140808391084021 4688 25236195 SGTC_1467 k284-1082 293 µM -2.23636246049443 0.0104495531168262 no 3289 0.0126640190266044 4717 3334705 SGTC_1311 1190-0148 100 µM -2.25979227835599 0.00978368001019763 no 3290 0.0119170729357553 4740 1961333 SGTC_2826 7992541 19.48 µM -2.2673748252924 0.00957627292419904 no 3291 0.0116836690128298 4712 2985066 SGTC_1769 st044406 64.4 µM -2.26801182543145 0.00955902521376708 no 3292 0.0116642429637447 4733 670903 SGTC_379 3970-0972 5.9 µM -2.27090057638919 0.00948114843491845 no 3293 0.0115764986833866 4739 2898042 YBL034C STU1 SGTC_2774 tamoxifen 10.92 µM -2.27455089724079 0.00938353463099302 no 3294 0.0114664422803525 4721 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  SGTC_456 gingerol 170 µM -2.27975796287349 0.00924581341977357 no 3295 0.0113110237297868 4729 442793 A herb. SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM -2.28083837583816 0.00921746030358449 no 3296 0.011279006300421 4746 368090 SGTC_2497 7-hydroxyflavone 100 µM -2.29663084816614 0.00881162353669216 no 3297 0.0108199186654492 4722 5281894 SGTC_3135 9127742 49.47 µM -2.30498684477011 0.00860329334637895 no 3298 0.0105836550962211 4753 3643468 SGTC_1919 st067113 52.3 µM -2.31420567620193 0.00837847558549525 no 3299 0.0103282213828159 4695 1268243 SGTC_1469 k284-2957 126 µM -2.31595721246958 0.00833634918915201 no 3300 0.0102803025054551 4763 23884841 SGTC_2998 9066762 71.4286 µM -2.32246910666707 0.00818135755169115 no 3301 0.010103845010797 4721 4945196 SGTC_3227 9130768 49.47 µM -2.33657136952037 0.00785435716867407 no 3302 0.00973074129964932 4772 17720899 SGTC_1046 2001-0062 216 µM -2.34864492038126 0.00758359080040074 no 3303 0.00942093268838499 4735 739778 SGTC_1772 st048439 82.2 µM -2.39446313608382 0.0066293809413719 no 3304 0.00832235826805396 4754 2927068 YDL195W SEC31 SGTC_2108 5365811 200 µM -2.39705616379401 0.00657870103927043 no 3305 0.00826369509722051 4752 780283 SGTC_2923 7992654 58.14 µM -2.40616462880027 0.0064033837779769 no 3306 0.00806049906668777 4722 2985126 SGTC_2902 5787006 60.46 µM -2.41173386569225 0.00629823697645548 no 3307 0.00793843295996337 4742 591003 SGTC_2037 5169046 200 µM -2.45969653020513 0.0054541494420695 no 3308 0.00695272702700134 4766 5718022 SGTC_3203 9113543 49.47 µM -2.47707674407999 0.00517405386512559 no 3309 0.00662317080238286 4736 17018012 SGTC_2560 caryophyllene 100 µM -2.4827945037504 0.0050847471094255 no 3310 0.00651781318169748 4774 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor. SGTC_802 4112-3352 742 µM -2.49692858259715 0.0048698469550517 no 3311 0.00626370919169881 4763 704594 SGTC_1144 3486-0183 12.5 µM -2.50597307459744 0.0047366146940277 no 3312 0.0061057459285198 4781 6744069 SGTC_2214 7179297 48.276 µM -2.53186756354057 0.00437296656836223 no 3313 0.00567284173425735 4777 769744 SGTC_920 mycophenolic acid 780.421 nM -2.53842702365475 0.00428490287333723 no 3314 0.00556760116399516 4745 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_1546 5-methoxyflavanone 78.7 µM -2.55588107388921 0.00405824711193833 no 3315 0.00529596561940405 4778 147795 SGTC_2825 7998094 58.44 µM -2.59211437620997 0.0036216748534975 no 3316 0.00476940264430405 4742 2987815 SGTC_426 0988-0037 14.6 µM -2.5980552488044 0.00355426085127464 no 3317 0.00468767039840046 4750 5383008 SGTC_1007 4101-0031 70 µM -2.60661017466673 0.00345916268048138 no 3318 0.0045721700186901 4766 1146276 SGTC_582 0987-0078 156 µM -2.65541872600144 0.00295902488823072 no 3319 0.00396050091170825 4788 1625765 SGTC_66 0109-0187 42.4 µM -2.65673948958804 0.00294644667082789 no 3320 0.00394501935978666 4670 759417 SGTC_1028 k015-0029 4.8 µM -2.68183985588954 0.00271638806725359 no 3321 0.00366092504206972 4764 4588309 SGTC_71 0417-1750 47.813 µM -2.68729273938833 0.00266860611843228 no 3322 0.00360168955041389 4745 6811472 SGTC_1539 benzyladenosine 56 µM -2.79551523118389 0.00186452216239361 no 3323 0.0025908530031643 4794 92208 A nucleotide analog. SGTC_1197 1601-0112 267 µM -2.81016487951198 0.00177453927730498 no 3324 0.00247580629620018 4778 7350313 SGTC_229 benomyl 22.8748 µM -2.82145780741963 0.00170789110827817 no 3325 0.00239029628295091 4799 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C SGTC_2904 7225135 42.03 µM -2.84202033812302 0.00159235901944617 no 3326 0.00224143158505827 4786 4446116 SGTC_926 2268-1401 59.4 µM -2.84423502693993 0.0015803502984143 no 3327 0.00222590983005522 4775 2931578 SGTC_913 3487-1245 167 µM -2.855986402035 0.00151800071646024 no 3328 0.00214516754212968 4761 4016153 SGTC_3126 9127922 49.47 µM -2.95008469777994 0.00109408298728181 no 3329 0.00158843413150708 4750 45595682 SGTC_1527 coumarin 137 µM -2.97120459245541 0.00101526881679766 no 3330 0.00148317047931262 4784 323 A hepatotoxic, DNA x-linker. SGTC_2824 7998404 51.95 µM -2.98735728105608 0.00095854485571295 yes 3331 0.00140700324085801 4778 837851 SGTC_500 h-89 112 µM -2.98791905946196 0.000956625452235001 yes 3332 0.00140441965544445 4790 449241 Protein kinase A inhibitor; also known to inhibit several other kinases. SGTC_1512 0259-0544 12.2 µM -3.00242224085135 0.000908278527998652 yes 3333 0.00133920194764292 4779 18476 SGTC_2762 leflunomide 42.06 µM -3.04939315998583 0.000766694773588739 yes 3334 0.00114652088780574 4791 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1 SGTC_917 harmaline 728.087 nM -3.08447725556314 0.000674527461332336 yes 3335 0.00101955100288555 4751 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7 SGTC_2800 7887935 81.82 µM -3.08532382129089 0.000672435433086456 yes 3336 0.00101665322585988 4782 2961002 SGTC_2079 5212404 121 µM -3.10788929276531 0.000618830453364694 yes 3337 0.000942143191450782 4780 758462 SGTC_574 1315-0397 40 µM -3.11200115629803 0.000609498366935578 yes 3338 0.000929118856263547 4791 6794277 SGTC_3184 9108758 49.47 µM -3.12511993566399 0.000580586542648372 yes 3339 0.000888662890504531 4808 902885 SGTC_2917 7979103 53.79 µM -3.15235465152118 0.000524568606705461 yes 3340 0.000809797154426275 4788 2980565 SGTC_1957 st077035 62.4 µM -3.17159219510767 0.000488060691765032 yes 3341 0.000758028683700669 4792 705593 SGTC_2775 cyproheptadine 69.59 µM -3.24308643032502 0.000372024115503146 yes 3342 0.000591211678766158 4795 2913 A selective serotonin reuptake inhibitor. SGTC_1748 st037455 53.6035 µM -3.24373544023923 0.000371099310953684 yes 3343 0.000589866331219021 4782 580690 SGTC_1745 st081495 74 µM -3.2444731813441 0.000370050662375983 yes 3344 0.00058834048637952 4737 13842402 YBL026W LSM2 SGTC_36 0335-0881 14.2 µM -3.3253408206031 0.000270424026485195 yes 3345 0.000441552553763225 4778 23828853 SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM -3.49940516861597 0.000134498169991452 yes 3346 0.000233148718794086 4784 6708739 YPR165W RHO1 SGTC_2643 anethole 100 µM -3.54126749222594 0.000113161152931947 yes 3347 0.000199104824388314 4802 637563 An anti-fungal, anti-helmenthic and channel blocker. SGTC_576 1073-0113 22.7 µM -3.57600925834592 9.79102979575154e-05 yes 3348 0.000174439650432308 4805 5439563 SGTC_1102 cgs 12066b 26.1 µM -3.58814576745755 9.30540933524659e-05 yes 3349 0.000166519043041983 4810 6438352 A 5-HT1B full agonist. SGTC_1963 st076565 50.3 µM -3.68825881366574 6.08010892093917e-05 yes 3350 0.000112896958144245 4810 4914280 SGTC_2606 farnesol 9.78 µM -3.75374602539426 4.57632814569925e-05 yes 3351 8.71056898479137e-05 4801 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_3143 9086658 49.47 µM -3.7807304932059 4.06534024845669e-05 yes 3352 7.8184437536869e-05 4790 25236626 SGTC_915 methyl methanesulfonate (MMS) 110 mM -4.13286639767231 8.07683084103735e-06 yes 3353 1.79133499507836e-05 4789 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks. SGTC_78 0336-0123 156.75 µM -4.39975339225872 2.17261112396467e-06 yes 3354 5.41869825250443e-06 4802 6765896 SGTC_1843 st055809 45.5 µM -5.31386621805316 1.35376764940176e-08 yes 3355 5.36617119159839e-08 4809 16413835 SGTC_2926 9010726 65.15 µM -7.00910431262751 9.95597456572413e-14 yes 3356 1.19924294971324e-12 4810 2994293