SGTCid condition conc unit YGL042C|YGL042C.score YGL042C|YGL042C.strain.pval YGL042C|YGL042C.strain.significant YGL042C|YGL042C.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene SGTC_72 0744-0168 198.391 µM 32.3014835692717 4.3340078989433e-230 yes 1 3.33361760358611e-229 1 677577 SGTC_108 0509-0257 621.132 µM 7.38709212290837 6.85936486703485e-14 yes 2 7.50373127826427e-14 7 536624 SGTC_3037 9091026 49.47 µM 7.23245398029066 2.1770766070647e-13 yes 3 2.37171703210241e-13 23 25236398 YIL048W NEO1 SGTC_59 0330-0160 1.33 µM 6.46523490300423 4.73189011863256e-11 yes 4 5.05707844480207e-11 30 4293482 SGTC_1754 st042065 16.137 µM 6.23163040628746 2.17121758085014e-10 yes 5 2.30802750640307e-10 93 1126236 YIL048W NEO1 SGTC_1800 st050079 29.0735 µM 6.1358711199096 3.99218011323799e-10 yes 6 4.23468998344664e-10 34 3645560 SGTC_1941 st076221 61.8 µM 6.07120799232605 5.99256869314311e-10 yes 7 6.34758172121103e-10 31 2828568 SGTC_1339 1486-1321 22.7 µM 5.59513659079634 1.05097025542355e-08 yes 8 1.10224072169423e-08 4 3469382 SGTC_2679 rapamycin 1 nM 4.74873715474113 9.90961051654951e-07 yes 9 1.02345381820624e-06 104 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2 SGTC_1818 st052136 56.3 µM 4.72865786434215 1.09452793045929e-06 yes 10 1.13004431205979e-06 26 674169 SGTC_1801 st050089 28.441 µM 4.4816807639327 3.60057467513364e-06 yes 11 3.7028733445811e-06 93 5008493 YIL048W | YNL267W NEO1 | PIK1 SGTC_149 3970-0822 46.1 µM 4.15017409722993 1.62311101536685e-05 yes 12 1.66111243229869e-05 88 3114250 YBL034C STU1 SGTC_15 0266-0086 27.098 µM 4.07461963475789 2.2541238200573e-05 yes 13 2.30448076554704e-05 58 1712902 YIL048W NEO1 SGTC_1974 st069448 26.9 µM 3.98995599235923 3.23578622953792e-05 yes 14 3.30427777707907e-05 21 6323587 YNR016C ACC1 SGTC_2026 5148700 152 µM 3.92126913911682 4.31682785852024e-05 yes 15 4.40419066766438e-05 16 79838 SGTC_43 0570-0105 72.5 µM 3.86915893783561 5.3558845237306e-05 yes 16 5.4605717647769e-05 99 1114046 YDL195W SEC31 SGTC_528 3492-0019 172 µM 3.74471285769951 8.87085550375946e-05 yes 17 9.0300103456889e-05 237 2869262 SGTC_1803 st050068 52.4 µM 3.61058205575317 0.000150307612230962 yes 18 0.000152755313166795 205 3984059 YIL048W | YNL267W NEO1 | PIK1 SGTC_1342 1486-1464 234 µM 3.49906506339051 0.000230004406462788 yes 19 0.000233446318304485 26 3253938 SGTC_2018 5133068 143 µM 3.49657604059686 0.000232167500686664 yes 20 0.00023563507906301 35 785362 SGTC_2031 5180455 200 µM 3.46392627033781 0.000262356466396354 yes 21 0.000266176200038935 19 29949 SGTC_1477 0139-0234 16 µM 3.4458793294155 0.000280575085073169 yes 22 0.00028460223604534 19 620880 SGTC_104 0074-0074 590.992 µM 3.3697593925577 0.00037115908180495 yes 23 0.000376169222043529 16 3943124 SGTC_2013 4024628 200 µM 3.2350221820059 0.000600928484781906 yes 24 0.000608166403995634 75 5230760 SGTC_347 4534-1311 26.2 µM 3.21703430982834 0.000640027330404558 yes 25 0.000647615542463952 31 2862016 SGTC_1131 3454-3128 32.3 µM 3.20766067985556 0.000661320363687307 yes 26 0.000669096418967812 80 710982 SGTC_919 tnp00227 403.569 nM 3.19441716944432 0.00069251968679322 yes 27 0.000700567431082472 78 1269246 A methoxyflavone. YNL221C POP1 SGTC_1629 st005085 44.9 µM 3.18927913844164 0.000704985246552687 yes 28 0.000713140403526569 65 24207091 SGTC_2701 st077767 14.721 µM 3.16915576791903 0.000755825377503799 yes 29 0.000764412180867575 84 5721188 SGTC_3029 9088683 49.47 µM 3.14388335449215 0.000824455325869095 yes 30 0.000833609410041703 46 25236615 SGTC_1844 rapamycin 4 nM 3.13027870741939 0.000863731310436602 yes 31 0.000873202620917948 223 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2 SGTC_2857 9024691 58.44 µM 3.08537221836365 0.00100590897290316 no 32 0.00101648779226472 66 16478292 SGTC_1512 0259-0544 12.2 µM 3.07889008846417 0.00102812011961296 no 33 0.00103886660267631 65 18476 SGTC_3346 9158254 43.5805 µM 3.06313406901032 0.00108399716374918 no 34 0.00109515952643593 62 17639500 SGTC_879 0831-1030 162 µM 2.97638494095215 0.00144467416747689 no 35 0.0014583425254523 116 1549252 SGTC_1870 st057514 26.5 µM 2.95364676792251 0.00155582935703656 no 36 0.00157021618740667 69 5393161 SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM 2.93165477627871 0.00167070025312737 no 37 0.00168580656022298 79 688761 SGTC_1572 epiandrosterone 68.9 µM 2.92652304771918 0.0016985928614659 no 38 0.00171387053420328 65 441302 A steroid. SGTC_1719 st032227 49.2 µM 2.89984667254986 0.0018505365382919 no 39 0.00186672618994119 81 3125804 SGTC_109 0132-0036 33.701 µM 2.87725110351379 0.00198879141448221 no 40 0.00200578117755925 54 67274 A color developer. SGTC_1617 st002906 78 µM 2.80419438555936 0.00250237760305764 no 41 0.00252212416784765 90 5150859 SGTC_1906 st060206 94.7 µM 2.8007736347247 0.00252913145494044 no 42 0.00254901329052039 83 5133468 SGTC_949 1165-0505 146 µM 2.76651006036343 0.00281172585398848 no 43 0.00283299183091828 94 6244267 SGTC_428 3448-4153 16.5 µM 2.7609633368188 0.00286006235096706 no 44 0.00288155728161074 102 3834874 SGTC_1232 0279-0259 161 µM 2.75545176428545 0.00290883355304794 no 45 0.00293055729846324 87 1560000 SGTC_1316 1272-0050 65.9 µM 2.75313275839013 0.00292957730130814 no 46 0.00295139770848791 52 7340392 SGTC_1206 3978-0017 132 µM 2.74913234862118 0.00296567500762067 no 47 0.00298766269657978 94 3873677 SGTC_37 0566-0070 1.56 µM 2.73746563885149 0.003073250022095 no 48 0.00309572938667883 102 1626686 SGTC_2979 9012552 45.46 µM 2.73481373867594 0.00309818725530223 no 49 0.00312077916251088 36 17100905 SGTC_1603 st002045 67.8 µM 2.72211376983538 0.0032201555469422 no 50 0.00324329035161694 69 5887985 SGTC_90 0870-0863 4.608 µM 2.6924964728649 0.00352153915610984 no 51 0.00354596428571179 126 1738164 SGTC_3022 9087993 49.47 µM 2.67041744665661 0.0037624422286417 no 52 0.00378784988343912 48 17173644 SGTC_942 3253-1115 227 µM 2.66779038302705 0.0037920682266338 no 53 0.00381759388205695 104 46497897 SGTC_115 0527-0192 112.043 µM 2.66248118235496 0.00385258051348753 no 54 0.00387834532504568 181 4233931 SGTC_143 4032-1194 15.74 µM 2.64633717740554 0.00404193590745301 no 55 0.00406843332500394 177 1806963 SGTC_1085 doxorubicin 7.67 µM 2.62675797214349 0.00428273511516231 no 56 0.00431013115069094 105 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_3036 9090181 49.47 µM 2.61699369732826 0.00440755099872263 no 57 0.00443539896159854 49 25236586 SGTC_1928 4'-methoxychalcone 40.3 µM 2.60935147077181 0.00450749756042679 no 58 0.0045357008424919 65 641818 SGTC_1051 3253-3903 78 µM 2.59828509399059 0.00465581341381114 no 59 0.00468453353514165 116 5509239 SGTC_2606 farnesol 9.78 µM 2.56903278396782 0.00506904283762942 no 60 0.00509914044437774 109 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_2086 5274770 176.623 µM 2.55056891283592 0.00534638935413313 no 61 0.00537736299503084 121 689278 SGTC_3184 9108758 49.47 µM 2.54612065447469 0.00541519132978594 no 62 0.00544637657851228 48 902885 SGTC_1287 0971-0001 34.6 µM 2.54466654769305 0.0054378523253419 no 63 0.00546910678569107 152 4665869 SGTC_2904 7225135 42.03 µM 2.53368752570874 0.0056116889467371 no 64 0.00564346649368941 60 4446116 SGTC_2709 st078560 56 µM 2.5142413945707 0.00593173217454004 no 65 0.00596443762947066 78 17250903 SGTC_349 k015-0014 24 µM 2.51016306113277 0.00600087103331279 no 66 0.00603377117445208 123 2196908 SGTC_227 fluconazole 33.516 µM 2.50965859854058 0.00600947250509446 no 67 0.00604239672700421 184 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C SGTC_445 e6 berbamine 66 µM 2.50841553001296 0.00603071443433292 no 68 0.00606369799355841 255 6610268 A calcium/calmodulin antagonist. SGTC_1486 3970-0793 4.53 µM 2.50087672048799 0.00616097138067067 no 69 0.00619431473644686 69 2844330 SGTC_1146 3579-1023 7 µM 2.49586815702304 0.00624888236109377 no 70 0.00628246465138104 117 X1146 SGTC_214 4373-3496 70 µM 2.48810915020493 0.00638726340508408 no 71 0.00642121557764588 207 3779166 SGTC_221 trifluoperazine 10.304 µM 2.47859467175878 0.00656064997612695 no 72 0.00659505509569909 351 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1 SGTC_2818 7996756 12.99 µM 2.47586773218519 0.00661110562026503 no 73 0.00664564039813325 86 2241621 SGTC_3016 9080866 49.47 µM 2.47532972404942 0.00662110062613186 no 74 0.00665566097514116 140 17066299 SGTC_1325 1431-0015 227 µM 2.44623665111169 0.00718187379160708 no 75 0.00721781067029726 108 1103340 SGTC_429 1112-0049 25.5 µM 2.43918364374207 0.00732397445479761 no 76 0.00736024267294915 152 2836170 SGTC_3165 9101544 49.47 µM 2.41515647912578 0.00782683811280194 no 77 0.00786422549718176 108 5002184 SGTC_2753 fluvastatin 17.09 µM 2.4107363633566 0.00792258451425566 no 78 0.00796017589258701 136 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5 SGTC_315 k915-0449 187 µM 2.38431954613857 0.00851657334789339 no 79 0.00855536874494678 190 20970215 YNL149C PGA2 SGTC_1951 sophoraflavanone G 9.2 µM 2.36961933054118 0.00886375170247486 no 80 0.00890320398453774 151 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity. SGTC_3172 9105863 49.47 µM 2.35133371115726 0.00931287063804323 no 81 0.00935312437641448 49 2348785 SGTC_2735 sertaconazole 140 nM 2.34219128079757 0.00954479625713169 no 82 0.00958544341437259 72 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C SGTC_714 4296-0578 26.1 µM 2.33761016165976 0.00966289785370037 no 83 0.00970374016317213 45 1589775 SGTC_2636 apigenin dimethyl ether 100 µM 2.33598361668925 0.00970513644252168 no 84 0.00974604771084248 197 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_2731 amoxapine 43.43 µM 2.32365224781009 0.0100306416899954 no 85 0.0100720698640804 45 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine. SGTC_1563 conessine 56.1 µM 2.31257914823787 0.0103310116014792 no 86 0.0103728945331996 161 441082 An anti-amoebic, histamine inhibitor. SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM 2.31048984777607 0.0103885572968417 no 87 0.0104305249772531 231 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_597 k018-0003 82.8 µM 2.3101534824047 0.0103978478893521 no 88 0.0104398291815516 119 6786234 SGTC_1966 st070145 16.1 µM 2.30706940883753 0.0104833698368252 no 89 0.0105254755109599 144 3748532 SGTC_3236 9132701 49.47 µM 2.30426175253515 0.0105617590581978 no 90 0.0106039772955119 143 24282524 SGTC_1322 1348-1070 12 µM 2.30297373423983 0.0105978908222508 no 91 0.0106401604810009 93 6758089 SGTC_113 0099-0221 2.5 µM 2.29756910122388 0.0107506790665235 no 92 0.0107931629751073 156 89219 SGTC_2348 9022543 33.42 µM 2.29283762199859 0.0108860081626846 no 93 0.0109286775742849 152 3162678 YDL140C RPO21 SGTC_930 2810-3379 265 µM 2.28232079505003 0.0111921293008802 no 94 0.0112352038489976 156 1015764 SGTC_2287 7945887 168.79 µM 2.26330114296969 0.0117647856342607 no 95 0.0118085659443739 128 1245853 SGTC_70 0141-0289 43.283 µM 2.25993736264458 0.0118686680230493 no 96 0.0119125693142993 427 352408 SGTC_1690 st023502 41.2 µM 2.25595617545217 0.0119926450189035 no 97 0.0120366879330015 129 24207482 SGTC_1130 3454-2858 15.9 µM 2.25479637561546 0.0120289725968204 no 98 0.0120730564447489 232 715628 YIL048W NEO1 SGTC_573 3702-0553 84.7 µM 2.23807752143201 0.0125633430690951 no 99 0.0126080001226289 134 1222756 SGTC_1466 k213-0079 57.5 µM 2.23021132725367 0.0128217929720097 no 100 0.0128667083112 162 3657981 SGTC_1328 1441-0025 69.2 µM 2.21761827105241 0.0132451228531294 no 101 0.0132904355180314 132 4562601 SGTC_2978 9011784 42.97 µM 2.21398203412297 0.0133695838777848 no 102 0.0134150074203634 223 2994934 SGTC_2480 5767542 37.17 µM 2.20698589120335 0.0136118906841637 no 103 0.0136575225218284 133 2867358 SGTC_1620 st003704 16.5 µM 2.20077040890478 0.0138303295364787 no 104 0.0138761407216509 137 2834414 SGTC_2592 piperlongumine 83.33 µM 2.19571105582685 0.0140103625702525 no 105 0.014056315667316 183 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_1756 st041558 35.5 µM 2.19513219643005 0.014031089036474 no 106 0.0140770581328092 156 3955792 SGTC_610 4215-0184 155 µM 2.177720545561 0.0146669974135058 no 107 0.0147134241734132 180 5605015 SGTC_2110 5483698 200 µM 2.17098752780358 0.0149194665436539 no 108 0.0149660575910178 161 2848765 YHR062C RPP1 SGTC_1046 2001-0062 216 µM 2.16679634009092 0.0150785037316741 no 109 0.015125193323856 173 739778 SGTC_412 gemfibrozil 100 µM 2.15271418439596 0.0156235749809932 no 110 0.015670574017127 127 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels. SGTC_531 3788-1495 174 µM 2.15045951809107 0.0157123970155615 no 111 0.015759442406769 194 2896655 SGTC_1233 0325-0408 14.2 µM 2.14982873799905 0.0157373238589577 no 112 0.0157843820575021 185 12874 SGTC_897 1000-0139 31.4 µM 2.14570924434041 0.015900951503529 no 113 0.0159480915939215 153 6151020 SGTC_1186 1319-0216 26 µM 2.13447708214464 0.016354526232665 no 114 0.0164018738535524 193 4565136 SGTC_2774 tamoxifen 10.92 µM 2.12923278005505 0.0165700666460574 no 115 0.016617503051265 173 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  SGTC_156 3474-0145 5.642 µM 2.12662098142086 0.016678315231594 no 116 0.0167257938792425 225 2265471 SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM 2.11220553834078 0.0172867243537555 no 117 0.0173344118500135 210 5024745 SGTC_2284 7945075 39.21 µM 2.1014220277357 0.0177541521219985 no 118 0.0178019679866521 219 1245402 SGTC_3115 9123671 49.47 µM 2.098747568786 0.0178717355993392 no 119 0.0179195794820089 130 3286988 SGTC_96 0929-0093 37.281 µM 2.08801191761752 0.0183504392093592 no 120 0.0183983798304018 174 6991579 SGTC_1763 st044482 94.5 µM 2.08784573300741 0.018357934421427 no 121 0.0184058763387637 199 88505 SGTC_1569 carminic acid 40.6 µM 2.08330561610928 0.0185637126630557 no 122 0.0186116875782795 198 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_2560 caryophyllene 100 µM 2.07786874436216 0.0188127167809282 no 123 0.0188607250035428 210 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor. SGTC_1455 4262-0120 131 µM 2.06609409775289 0.0193617411556402 no 124 0.019409797723649 220 1529587 SGTC_2856 9022925 19.48 µM 2.05902835972684 0.0196976913929864 no 125 0.0197457609057392 219 4944862 SGTC_87 0100-0052 35.5 µM 2.04030458401386 0.0206119562418156 no 126 0.020659999267141 436 200187 YGR083C | YDR527W GCD2 | RBA50 SGTC_1712 st032288 53.4 µM 2.04009694018798 0.0206222934911739 no 127 0.0206703357135309 430 2883011 SGTC_399 oxolinic acid 75 µM 2.03583744855979 0.0208353170993303 no 128 0.0208833403225286 166 4628 A DNA gyrase inhibitor. SGTC_309 k408-0051 1.48 µM 2.03577439857866 0.0208384842636081 no 129 0.0208865071691981 302 3640463 SGTC_400 oxethazaine 37.5 µM 2.0229273066621 0.0214923857353945 no 130 0.0215403213762212 211 4621 A local anesthetic. SGTC_2343 7990716 14.84 µM 2.02267092804909 0.0215056096298192 no 131 0.0215535430660465 201 6456862 SGTC_1366 1683-0113 21.9 µM 2.02236059330742 0.0215216257571339 no 132 0.0215695565002047 180 708623 SGTC_2386 9075165 157.42 µM 2.02119200219575 0.0215820262938467 no 133 0.0216299466535478 159 16452277 SGTC_1936 st074407 74.3 µM 2.01908856872274 0.0216911066857065 no 134 0.0217390073880187 266 809813 SGTC_2644 guaiazulene 100 µM 2.01757302457667 0.0217699885526039 no 135 0.0218178743166418 152 3515 A coloring agent. SGTC_1376 2910-0861 41.3 µM 2.01750141192163 0.0217737218746522 no 136 0.0218216069167045 234 1112859 SGTC_210 3551-0445 56.827 µM 2.00881912580041 0.0222303729731958 no 137 0.0222781595871905 237 2865180 YOR207C RET1 SGTC_338 4055-0136 114 µM 2.00280793159908 0.0225512484877652 no 138 0.0225989541005552 229 2900563 SGTC_2668 2',4'-dihydroxychalcone 15.08 µM 1.9960645279009 0.0229158477933936 no 139 0.0229634497458953 167 5357218 A potent inhibitor of glutathione S-transferases. SGTC_2922 7999257 32.47 µM 1.99558942885818 0.0229417214262806 no 140 0.0229893155586092 172 2988377 SGTC_16 erodoxin 22.806 µM 1.99208484587272 0.0231333403678853 no 141 0.0231808746897262 303 3967339 Erodoxin inhibits Ero1. YML130C ERO1 SGTC_3327 9140648 26.9345 µM 1.99032189301799 0.0232302411018191 no 142 0.0232777439136653 195 8029710 SGTC_2917 7979103 53.79 µM 1.98792987023775 0.0233622647995282 no 143 0.0234097233234221 270 2980565 SGTC_2250 alverine citrate 130 µM 1.9739162452785 0.0241484706870256 no 144 0.0241956336196906 438 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1 SGTC_409 arachidonic acid 100 µM 1.96652096792287 0.0245722498611831 no 145 0.0246192313412551 214 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes. SGTC_1027 k015-0025 8.67 µM 1.96179759072969 0.024846171005548 no 146 0.0248930271530019 230 3598955 SGTC_806 3966-4455 5.86 µM 1.95874478199005 0.0250245703934344 no 147 0.0250713415651853 197 714982 SGTC_510 ag-490 170 µM 1.9475090133904 0.0256904390228912 no 148 0.0257368701082064 165 5328779 SGTC_3008 9078912 71.4286 µM 1.94622781522134 0.0257673005198513 no 149 0.0258136900553592 212 16648731 SGTC_81 0411-0046 9.971 µM 1.94298970728218 0.0259624190132683 no 150 0.026008700970806 208 12925265 SGTC_2688 kanamycin b 96.69 µM 1.93170158311896 0.0266522968529287 no 151 0.0266981746365057 820 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis. SGTC_146 3448-8650 53.125 µM 1.92077348942472 0.0273346926985102 no 152 0.0273801350326329 427 2891488 YIL048W NEO1 SGTC_3005 9076496 71.4286 µM 1.91933956309118 0.0274253051780046 no 153 0.0274706870817257 188 21368410 SGTC_79 0052-0007 94.094 µM 1.91902035862019 0.0274455103518782 no 154 0.0274908786981439 239 2801472 SGTC_752 1896-0090 130 µM 1.91055960581306 0.0279856048764637 no 155 0.028030599792808 237 772567 SGTC_3319 9138450 16.7555 µM 1.90710721701123 0.0282085177813468 no 156 0.0282533524421741 223 2029690 SGTC_1305 1181-0477 144 µM 1.90702662394218 0.028213739096484 no 157 0.0282585699611754 230 6252086 SGTC_944 3370-0224 231 µM 1.90069309318433 0.02862658726652 no 158 0.0286711118768788 256 4580514 SGTC_1760 st045453 10.4495 µM 1.89925429375822 0.0287210717729271 no 159 0.0287655246135985 346 3323419 YIL048W NEO1 SGTC_3041 9091929 49.47 µM 1.89832858158309 0.0287819993408003 no 160 0.028826405572145 266 25236887 SGTC_1300 1094-0077 113 µM 1.89400596899229 0.0290679247204925 no 161 0.0291121087934627 227 5532636 SGTC_1028 k015-0029 4.8 µM 1.89188366661253 0.0292091689715294 no 162 0.0292532412301079 301 4588309 SGTC_3025 9087895 49.47 µM 1.88882708831387 0.0294135928811972 no 163 0.0294575009065843 256 17173641 SGTC_1949 st076024 69.1 µM 1.88232588540302 0.0298523449536959 no 164 0.0298958909942316 280 2921930 SGTC_849 0386-0493 241 µM 1.87104703745444 0.0306264043458919 no 165 0.0306692807896709 230 726119 SGTC_2427 5545055 42.75 µM 1.86862894197421 0.0307945022359886 no 166 0.0308372281398937 282 5372858 SGTC_3013 9080133 71.4286 µM 1.86633260166855 0.0309548424981602 no 167 0.0309974231297725 289 17050193 SGTC_1640 st009078 66.4 µM 1.86415871224294 0.0311072687425782 no 168 0.0311497097612919 201 690618 SGTC_172 1112-0046 2.638 µM 1.85623304701856 0.0316682591541048 no 169 0.0317101738028269 230 2802135 YIL048W NEO1 SGTC_1728 st035614 33.7865 µM 1.85257029677805 0.0319303244863953 no 170 0.0319719865717156 351 15945546 SGTC_1915 st067105 30.6 µM 1.85039997552994 0.0320864516463292 no 171 0.0321279612717457 295 69751 YOR207C | YOR116C RET1 | RPO31 SGTC_888 0916-0002 6.97 µM 1.84829383634366 0.0322385637914024 no 172 0.0322799234565488 250 2802138 YIL048W NEO1 SGTC_377 3970-0964 33.1 µM 1.84727425334327 0.0323124148832828 no 173 0.0323537012387961 367 16481235 SGTC_2121 5257820 149.641 µM 1.84579702823666 0.0324196618240952 no 174 0.0324608411357275 270 791256 SGTC_2100 5377183 190 µM 1.84090019703775 0.0327772753520174 no 175 0.0328180927693496 276 2844202 SGTC_1981 st071826 47 µM 1.83692056150868 0.0330702964418791 no 176 0.0331108116993602 221 11838600 SGTC_873 0591-4978 488 µM 1.83666033524074 0.0330895318794808 no 177 0.0331300271257017 277 3305145 SGTC_1643 st009866 20.2 µM 1.834263719095 0.0332671189982573 no 178 0.0333074284773944 224 3156273 YOR207C RET1 SGTC_1897 st060201 15 µM 1.83304178371098 0.0333579650260053 no 179 0.0333981787673728 242 611878 SGTC_2907 7721985 69.9 µM 1.83138602708933 0.033481389791892 no 180 0.0335214726992929 281 3267881 SGTC_1963 st076565 50.3 µM 1.82214378954576 0.0341772564496675 no 181 0.0342165854497243 244 4914280 SGTC_2776 terbinafine 19.92 µM 1.8136076576012 0.0348304787370548 no 182 0.0348690753372253 294 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_2106 5357045 167.29 µM 1.81141678907382 0.0349997765659855 no 183 0.0350381795174427 282 668842 SGTC_929 2805-0021 398 µM 1.80730972349369 0.0353189667797351 no 184 0.0353570004005153 271 3098024 SGTC_3342 9147791 14.508 µM 1.80186638340011 0.0357456838374758 no 185 0.0357832151689882 267 1838168 SGTC_1226 3909-7979 35.4 µM 1.79940961633241 0.035939654956322 no 186 0.0359769547694802 333 6615510 SGTC_523 1934-0222 13.7 µM 1.79908339241535 0.0359654763037999 no 187 0.036002745147894 306 1361595 SGTC_1621 st003705 32.4 µM 1.79727593520661 0.0361088160296723 no 188 0.0361459123222105 323 24207032 SGTC_2799 7812892 81.82 µM 1.79482343699158 0.0363040581870422 no 189 0.0363409177222649 299 20205235 SGTC_3000 9075062 71.4286 µM 1.7934951048165 0.0364101663015317 no 190 0.0364468963359266 279 17057871 SGTC_2889 9059656 51.95 µM 1.78328325834613 0.0372343981966334 no 191 0.0372701026299268 284 3949838 SGTC_1993 st073995 70.8 µM 1.77742334638172 0.0377142145868038 no 192 0.037749306196614 274 3098394 SGTC_168 3970-0862 530.542 µM 1.77502260061428 0.0379122424039942 no 193 0.0379470777636878 528 3135186 SGTC_2051 5263410 176 µM 1.7724910217224 0.0381219803243891 no 194 0.0381565421816635 297 227584 SGTC_2655 perillic acid 100 µM 1.77181781198765 0.0381779138620231 no 195 0.0382124024179926 198 5702197 An apoptosis inducer. SGTC_1889 st059080 5.18 µM 1.76770475153904 0.0385211021347847 no 196 0.0385551376180512 317 176925 Isolated from Daphnopsis sellowiana. SGTC_499 genistein 192 µM 1.76742768270781 0.0385443104861474 no 197 0.0385783151247875 189 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger. SGTC_1247 0448-0043 5.84 µM 1.76412021347889 0.0388222377250391 no 198 0.0388558709838394 362 3089013 YGL099W LSG1 SGTC_2733 amorolfine 100 µM 1.76390818772528 0.0388401098169151 no 199 0.0388737190679087 153 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_53 0973-0023 39.979 µM 1.75988797317971 0.0391802520041484 no 200 0.0392134014499884 270 674768 SGTC_1807 st050092 58.9 µM 1.75907076153802 0.0392496902778363 no 201 0.0392827451855346 284 5008496 SGTC_2787 5284540 71.43 µM 1.75098720816561 0.0399419566246361 no 202 0.0399740567352587 303 736958 SGTC_1772 st048439 82.2 µM 1.74506522998674 0.0404553798055062 no 203 0.0404867575475456 343 2927068 YDL195W SEC31 SGTC_837 0091-0265 12.5 µM 1.74479495712424 0.0404789391649255 no 204 0.0405102834726227 310 759367 SGTC_218 alverine citrate 93.75 µM 1.74277505843138 0.0406553641983445 no 205 0.0406864573371664 263 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_1819 st053448 58.6 µM 1.73695228184635 0.0411674407475185 no 206 0.0411977969831196 295 2857616 SGTC_2826 7992541 19.48 µM 1.72552234498406 0.0421878367154445 no 207 0.0422166902182111 312 2985066 SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM 1.7242836155025 0.0422996417085602 no 208 0.0423283278247283 216 4620898 SGTC_3167 9103034 49.47 µM 1.71726038151838 0.0429380835638484 no 209 0.0429658037004009 221 5127859 SGTC_460 trequinsin 123 µM 1.71716626169136 0.0429466920389475 no 210 0.0429743990335382 263 5537 A vasodilator. SGTC_3293 9120939 62.045 µM 1.71673524080992 0.0429861322894135 no 211 0.0430137790337469 296 934087 SGTC_2306 7482397 179.52 µM 1.71412379021438 0.0432257173603485 no 212 0.0432529967148811 305 891448 SGTC_1857 st056007 79.3 µM 1.70836250342679 0.043758095641001 no 213 0.0437845501394525 267 619834 SGTC_2132 5317594 122.667 µM 1.70151136613417 0.0443980549831175 no 214 0.044423502670839 277 794577 SGTC_441 propafenone 146 µM 1.70117554386288 0.0444296167592232 no 215 0.0444550143664223 260 4932 Slows the influx of sodium ions into the cardiac muscle. SGTC_2142 5622915 118.518 µM 1.69564725341262 0.0449517883025097 no 216 0.0449763516100021 279 5322196 SGTC_2033 5192550 145 µM 1.69335361915993 0.0451698771445392 no 217 0.0451940888165757 297 182073 SGTC_2750 bromebric acid 70.15 µM 1.68090574124798 0.0463683658806735 no 218 0.0463906123157677 389 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2 SGTC_1222 0366-0074 1.18 µM 1.67714041397542 0.0467358809408501 no 219 0.0467575137921455 324 286520 SGTC_2880 9042983 58.44 µM 1.67626687841917 0.0468214755444045 no 220 0.0468429647654678 341 6464714 SGTC_178 4092-0806 87.505 µM 1.67623389210973 0.0468247102162901 no 221 0.0468461940041248 465 2169044 SGTC_1241 0364-0022 50.8 µM 1.67198828379054 0.0472425375057378 no 222 0.0472633162123997 364 4563895 SGTC_3051 9093778 49.47 µM 1.67176796767696 0.0472643009933256 no 223 0.0472850427975254 238 17217378 SGTC_2090 5301565 104.445 µM 1.66322432650401 0.0481144832396624 no 224 0.0481337699373807 382 2056344 SGTC_998 3996-0085 177 µM 1.65932133089592 0.0485069233551308 no 225 0.0485255295897451 385 715391 SGTC_1439 4092-1168 46 µM 1.65731820029624 0.0487093266276628 no 226 0.0487275797677407 320 2886240 SGTC_2274 7947094 46.08 µM 1.64227920509039 0.0502505597443914 no 227 0.0502660773145096 376 2971028 SGTC_177 1327-0068 8.361 µM 1.64130276219795 0.0503519567647191 no 228 0.0503672915064805 392 15389900 YOR207C | YLR033W RET1 | RSC58 SGTC_2868 9035608 32.47 µM 1.63498785141951 0.0510116603852722 no 229 0.0510257971867136 375 6462614 SGTC_2467 5474540 200 µM 1.63188418114442 0.0513384054145982 no 230 0.0513519435267711 374 5413519 SGTC_868 0527-0199 213 µM 1.63029141095521 0.0515067326824228 no 231 0.0515199609997312 361 2849450 SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM 1.61934347562363 0.0526756389958405 no 232 0.0526866906676073 348 6708514 SGTC_999 SEC7.066 22.7 µM 1.61384246421291 0.053270874049189 no 233 0.0532808005758983 410 740511 YDR170C SEC7 SGTC_896 0964-0007 44.5 µM 1.61342787873975 0.053315949308298 no 234 0.0533257901783361 332 6756758 SGTC_1699 st031318 29.054 µM 1.60831721573373 0.0538740860233967 no 235 0.0538828610345907 360 5340658 SGTC_2623 humulene 100 µM 1.60753022629871 0.0539604429015156 no 236 0.0539690521398722 306 6187145 An anti-inflammatory. SGTC_3169 9102970 49.47 µM 1.60617091051563 0.0541098596032091 no 237 0.0541181814772413 301 17027839 SGTC_1871 st057448 67.3 µM 1.60401794264698 0.0543471847899433 no 238 0.0543550488285632 387 691747 SGTC_2987 9018338 71.43 µM 1.60374194504081 0.0543776679170833 no 239 0.0543854730249942 368 5055682 SGTC_3221 9128209 49.47 µM 1.60076855590323 0.054706928458968 no 240 0.0547140952389931 327 16460723 SGTC_508 roscovitine 141 µM 1.59998853421488 0.0547935652293736 no 241 0.0548005635056792 315 160355 A CDKinase inhibitor. SGTC_1905 st060207 84.5 µM 1.59989670926068 0.0548037713301896 no 242 0.0548107497413392 342 1948547 SGTC_2394 5221648 200 µM 1.59795801821473 0.0550196026877626 no 243 0.0550261602734367 432 788586 SGTC_300 r073-0011 5.04 µM 1.59616280826661 0.0552200589083034 no 244 0.0552262244004184 418 2735780 SGTC_129 0088-0017 176.636 µM 1.59442953512771 0.0554141460817036 no 245 0.0554199308003339 395 182446 SGTC_1448 4255-0083 152 µM 1.59007251933981 0.0559044118225 no 246 0.0559092297560141 366 5399660 SGTC_525 k781-2675 26.7 µM 1.58061346738033 0.0569805509832649 no 247 0.056983222314773 415 3651118 YDL195W SEC31 SGTC_1437 4092-1038 11.6 µM 1.57793216366198 0.0572885466085176 no 248 0.0572905974740547 389 3977136 SGTC_1238 0333-0287 48.8 µM 1.5755551544357 0.0575626827019265 no 249 0.0575641790604568 376 7226 SGTC_2478 5763493 32.33 µM 1.57484526504911 0.0576447527078134 no 250 0.0576460826494764 374 1365576 YLR208W SEC13 SGTC_1457 k015-0032 57.3 µM 1.57225948831004 0.0579444715072944 no 251 0.0579451920989252 389 4302660 SGTC_2908 7930301 100 µM 1.57137149189228 0.0580476817410429 no 252 0.0580481919205662 421 2223178 SGTC_317 4495-0002 170 µM 1.56793881308272 0.0584480150576318 no 253 0.0584477063031438 332 15991618 SGTC_1854 st056233 32.9 µM 1.55917603110912 0.0594798006823907 no 254 0.0594773611174738 362 5393174 SGTC_3032 9089427 49.47 µM 1.55798843752195 0.0596207273596031 no 255 0.0596179945313631 358 17173707 SGTC_2372 9071633 200 µM 1.54807182494721 0.0608077261142888 no 256 0.0608025023511701 418 21321366 SGTC_2264 7948757 110.76 µM 1.54749391773355 0.0608774662568025 no 257 0.0608720949973624 369 2971411 SGTC_1114 scopoletin 1.73284 µM 1.5471081203686 0.0609240579474609 no 258 0.0609185880792077 349 5280460 A coumarin with genotoxic properties. SGTC_2122 5258151 111.688 µM 1.5428482050871 0.0614403715077105 no 259 0.0614338051486593 413 2173356 SGTC_1549 4'-methoxyflavonol 74.6 µM 1.54162705985878 0.0615890062619889 no 260 0.0615821229835399 378 97141 SGTC_2065 5221596 34.26 µM 1.53880655542179 0.0619333842282404 no 261 0.0619257645103083 398 788581 SGTC_2777 climbazole 1.536 µM 1.53738281106469 0.0621077903872122 no 262 0.0620997965652729 435 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2 SGTC_1722 st034304 3.6505 µM 1.53713636738158 0.0621380181665874 no 263 0.0621299594277759 421 4036148 YLR033W RSC58 SGTC_2786 7743617 45.45 µM 1.53647865342878 0.0622187468737246 no 264 0.0622105146503493 334 583674 SGTC_3267 9137951 49.47 µM 1.53403125359676 0.0625198628361781 no 265 0.0625109820816002 320 16643986 SGTC_1917 st066507 28.5 µM 1.53259252040717 0.062697406974409 no 266 0.0626881427740821 469 3156428 SGTC_1804 st050076 49.1 µM 1.53108982282364 0.0628832638024812 no 267 0.0628735973664314 402 3895976 SGTC_3243 9134147 49.47 µM 1.52907861212901 0.0631326859768965 no 268 0.0631224783966274 378 24282180 SGTC_2338 7999974 200 µM 1.52453354702242 0.0636991839464555 no 269 0.0636877416408535 435 315925 SGTC_2482 5981709 142.65 µM 1.52414229238926 0.0637481342937811 no 270 0.0637365849309734 442 877755 SGTC_2821 7996764 71.43 µM 1.51866299262422 0.0644367346378395 no 271 0.0644236731546569 445 2987135 SGTC_1527 coumarin 137 µM 1.51834759922481 0.0644765463097391 no 272 0.06446339705586 399 323 A hepatotoxic, DNA x-linker. SGTC_1657 st012939 43.4 µM 1.51819967345803 0.0644952253564923 no 273 0.0644820349089066 357 24207257 SGTC_2449 5812982 45.77 µM 1.51596496276526 0.0647779209773797 no 274 0.0647641060781712 367 776185 SGTC_1868 st057644 42.7 µM 1.51393737254655 0.0650352470914143 no 275 0.0650208621380944 432 688665 SGTC_3241 9133421 49.47 µM 1.51222362636716 0.0652533606154704 no 276 0.065238491257572 304 17018221 SGTC_488 nitrendipine 139 µM 1.50151913140438 0.0666286201291695 no 277 0.0666106710989011 435 4507 Dihydropyridine L-type calcium channel blocker. SGTC_669 0108-0021 26.2 µM 1.49835657887852 0.0670391925019337 no 278 0.0670203156949466 557 17201 SGTC_1546 5-methoxyflavanone 78.7 µM 1.49326227657829 0.0677046616217535 no 279 0.0676842730220425 432 147795 SGTC_311 1315-0136 58 µM 1.49321936197804 0.0677102891556882 no 280 0.0676898877295458 405 6759207 SGTC_2802 7925815 54.55 µM 1.49304821614092 0.06773273567127 no 281 0.0677122830774397 452 1262923 SGTC_447 ml7 120 µM 1.49019664877414 0.0681075773497824 no 282 0.0680862686485158 428 4216 Selective myosin light chain kinase inhibitor. SGTC_2947 9072639 7.68 µM 1.48893045367549 0.0682745326226452 no 283 0.0682528416163771 481 16488146 SGTC_2359 9039622 200 µM 1.48520416397557 0.06876769849596 no 284 0.0687448746600648 431 6463596 SGTC_1488 4013-0813 75.9 µM 1.48461952264918 0.0688453230916415 no 285 0.06882232046764 367 2910057 SGTC_52 0329-0193 875 nM 1.48459490290801 0.0688485934107213 no 286 0.0688255832515345 438 3739292 SGTC_1100 amiodarone 5.07 µM 1.48084239444445 0.0693484528227662 no 287 0.0693242882289773 464 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. SGTC_3122 9126309 49.47 µM 1.48058302086113 0.0693831061505441 no 288 0.0693588613260337 385 17591206 SGTC_3225 9130819 49.47 µM 1.46945962665426 0.0708818213100146 no 289 0.0708540823705841 437 4547121 SGTC_422 cantharidin 155 µM 1.46082472498267 0.0720622981422657 no 290 0.072031774329128 475 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_1425 4048-4433 7.33 µM 1.45917528551748 0.0722894976594698 no 291 0.0722584346195276 504 23734946 SGTC_592 k241-0073 46.5 µM 1.45797281448754 0.0724554758578059 no 292 0.0724240182380701 460 4230158 SGTC_814 3342-0569 96 µM 1.45665719275054 0.0726374066370852 no 293 0.0726055158823835 489 4346283 SGTC_3333 9141820 12.094 µM 1.45565347180932 0.0727764413250865 no 294 0.072744219117637 406 1939433 SGTC_2872 9044037 25.97 µM 1.45535358399681 0.0728180210744759 no 295 0.0727856996682524 354 6465195 SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM 1.45523738801131 0.0728341366536927 no 296 0.0728017767905678 524 91467 include heat shock SGTC_550 4123-0385 25.7 µM 1.44860545061677 0.0737584732489952 no 297 0.0737238990806171 433 5731123 SGTC_1036 k216-0215 33.5 µM 1.44687726199927 0.0740008087216966 no 298 0.0739656512681056 518 622330 SGTC_1539 benzyladenosine 56 µM 1.44563334001947 0.0741756140184918 no 299 0.0741400351162715 412 92208 A nucleotide analog. SGTC_2660 2',4'-dihydroxychalcone 17.14 µM 1.44542440316361 0.0742050063125209 no 300 0.0741693564888818 431 5357218 A potent inhibitor of glutathione S-transferases. SGTC_494 Boc-Gly-Val-Val-CHO 140 µM 1.44456293291643 0.0743262880152148 no 301 0.0742903453723732 422 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA. SGTC_448 monastrol 171 µM 1.44252134207752 0.0746143168307801 no 302 0.0745776776505033 433 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity SGTC_1358 1509-0022 2.48 µM 1.44124258863957 0.0747951575149104 no 303 0.0747580802009181 453 3258434 SGTC_1029 k015-0030 64.7 µM 1.43910439941467 0.0750982859878678 no 304 0.0750604728750305 448 2208316 SGTC_2537 larixol 68.93 µM 1.43887053929901 0.0751314968045676 no 305 0.0750936029719264 486 6708759 SGTC_3070 9117005 49.47 µM 1.4331044536874 0.0759538937192326 no 306 0.0759139944337363 366 8779016 SGTC_1937 st074714 47.2 µM 1.42831826541341 0.0766417226338875 no 307 0.0766001364143127 477 17250970 SGTC_2875 9039966 71.43 µM 1.41910376375877 0.0779792746682349 no 308 0.0779343834082741 402 6463691 SGTC_909 3448-9333 149 µM 1.41537694157541 0.0785252528499793 no 309 0.0784790033135311 427 3344074 SGTC_2078 5212016 200 µM 1.41407978982726 0.0787159634178965 no 310 0.0786692381973848 405 1899708 SGTC_2778 tioconazole 65.09 nM 1.41287130130315 0.0788939541167301 no 311 0.0788467843647068 512 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_3296 9122258 64.045 µM 1.41286013948515 0.0788955994907656 no 312 0.0788484256268431 482 4730474 SGTC_1056 3448-1962 115 µM 1.40636026532209 0.079858173932864 no 313 0.0798085864927367 445 715507 SGTC_2652 actinonin 100 µM 1.40406808245635 0.0801997361643795 no 314 0.0801492884610519 424 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase. SGTC_2464 5717415 7.67 µM 1.40279996658244 0.080389174171079 no 315 0.0803382484918066 506 5285744 SGTC_2333 9017922 200 µM 1.39837977906258 0.0810521292088076 no 316 0.080999526046696 468 3163164 SGTC_3294 9122953 26.2835 µM 1.39723706869275 0.0812241862553071 no 317 0.0811711465324395 481 16459826 SGTC_1384 3089-0840 101 µM 1.39720735909633 0.0812286632796419 no 318 0.0811756121906301 431 1069836 SGTC_114 0364-0001 490.298 µM 1.39497939478073 0.0815649323766511 no 319 0.0815110266264626 490 4003655 SGTC_1442 4112-3290 3 µM 1.39129250579798 0.0821237027641493 no 320 0.0820683727195396 499 704353 SGTC_877 0771-0151 33.1 µM 1.38935681489949 0.0824182204660636 no 321 0.082362137645835 527 6166523 SGTC_811 0416-0114 265 µM 1.3878287438217 0.0826512794607507 no 322 0.082594599952306 470 6612453 SGTC_410 α-linolenic acid 100 µM 1.38485264737955 0.0831066121988047 no 323 0.0830487643976906 522 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_2685 mycophenolic acid 18.85 µM 1.38264861074712 0.0834450363573885 no 324 0.0833863180749007 432 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_2752 diclazuril 33.15 µM 1.38131173039721 0.0836508149583535 no 325 0.0835915664887187 673 456389 An antifungal agent for coccidioides. YHR062C RPP1 SGTC_3312 9133330 71.43 µM 1.3812826097668 0.0836553015750271 no 326 0.0835960415381727 507 17617324 SGTC_2098 5376439 882.5 nM 1.38042902792309 0.0837868932948129 no 327 0.0837272938516229 524 2844116 SGTC_2178 5812956 200 µM 1.37436955901131 0.0847255190759314 no 328 0.0846634908002342 454 5403383 SGTC_3053 9095903 49.47 µM 1.37361429607011 0.0848430615548865 no 329 0.0847807281528307 469 17174018 SGTC_707 0865-0008 204 µM 1.37343225491603 0.0848714111159049 no 330 0.08480900408973 494 723043 SGTC_1670 st016595 4.04 µM 1.37126081809519 0.0852101202466416 no 331 0.0851468326298599 508 597879 SGTC_197 4544-0043 41.561 µM 1.37110677278953 0.0852341872499929 no 332 0.0851708369955833 536 896523 SGTC_2850 9015429 58.44 µM 1.36620814282951 0.08600217490654 no 333 0.0859368212136573 473 6457570 SGTC_1798 st045719 60.953 µM 1.36421529103887 0.0863160836654876 no 334 0.0862499085076486 445 3980186 SGTC_570 0987-0065 62.6 µM 1.35846926885157 0.0872259783358174 no 335 0.0871574137473571 384 3104428 SGTC_1134 3477-0009 42.5 µM 1.35746816560899 0.0873852350341485 no 336 0.0873162509662094 553 3973534 SGTC_2468 5987765 72.9 µM 1.35705397594698 0.0874511882590037 no 337 0.0873820303619999 505 26772094 SGTC_3121 9125696 49.47 µM 1.34655697196938 0.0891350974808922 no 338 0.0890614799719736 453 1235365 SGTC_2003 4023581 200 µM 1.33719839489209 0.0906566246621302 no 339 0.0905789428592395 520 16641307 SGTC_2141 5621638 7.665 µM 1.33711712269959 0.0906699218882872 no 340 0.0905922044235964 493 2856238 SGTC_1502 4534-4282 27.7 µM 1.33081603604748 0.09170527667283 no 341 0.09162477504485 490 3278949 SGTC_1777 st045864 34.765 µM 1.32790890395583 0.0921859004644052 no 342 0.0921041014459767 529 4691462 SGTC_3276 9139060 49.47 µM 1.32602657317929 0.0924980911984134 no 343 0.0924154477941423 459 4870619 SGTC_1190 1486-1332 13 µM 1.32512438558213 0.0926479989719795 no 344 0.0925649496481667 511 4150046 SGTC_847 0342-0274 5.54 µM 1.3244160364881 0.092765824354834 no 345 0.0926824557742845 529 18097 SGTC_2508 celastrol 40.54 µM 1.32159833887541 0.093235611748558 no 346 0.0931509684169585 466 122724 Celastrol is a natural product and antioxidant. SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM 1.3188111394288 0.0937020414621027 no 347 0.0936161296200125 549 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1 SGTC_1913 st060213 96.1 µM 1.31567108556264 0.0942295814882327 no 348 0.094142231524197 579 688959 SGTC_2897 9048598 12.99 µM 1.314737868566 0.0943867867089917 no 349 0.0942990074933642 508 6467404 SGTC_2810 7959871 45.46 µM 1.3082809660824 0.0954797867192866 no 350 0.0953890143131114 603 2974535 SGTC_1520 flindersine 88 µM 1.30799590288947 0.0955282549620509 no 351 0.0954373494743896 556 68230 Flindersine is a natural alkaloid of the quinoline subtype. SGTC_898 1000-0849 28.3 µM 1.30557532657655 0.0959405464844851 no 352 0.09584850775641 545 6751807 SGTC_163 TUB2.036 7.546 µM 1.30278928469202 0.0964167051461699 no 353 0.0963233549898358 728 15992207 YJR013W GPI14 SGTC_2665 lovastatin 100 µM 1.29764711924543 0.0973001019675134 no 354 0.0972043113621765 532 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1 SGTC_2073 5212005 126 µM 1.29536030484909 0.0976948666837236 no 355 0.0975979824319265 444 691789 SGTC_3255 9139072 49.47 µM 1.2950248477411 0.0977528740864942 no 356 0.097655828973451 557 17646060 SGTC_1860 st056228 74.6 µM 1.29363716447098 0.0979931012134183 no 357 0.0978953894909891 529 688679 SGTC_2618 avocadyne 43.43 µM 1.29214471613866 0.0982519471484862 no 358 0.0981535163753341 518 3015189 SGTC_1361 1608-0041 5.61 µM 1.29163333295017 0.0983407550741016 no 359 0.098242077415799 561 X1361 SGTC_1413 3910-0535 34.4 µM 1.28902827290281 0.0987940681333104 no 360 0.0986941288062516 561 2876951 SGTC_1706 st031321 9.9705 µM 1.28885372416896 0.0988244963687168 no 361 0.0987244722659557 545 6103185 SGTC_3113 9123498 49.47 µM 1.28868681276779 0.0988535996385385 no 362 0.0987534944413002 538 8897275 SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM 1.28723083966649 0.0991077343062303 no 363 0.0990069205535623 537 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_2677 mitomycin C 100 µM 1.28702290585116 0.0991440673356068 no 364 0.0990431522203013 490 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_2371 9071574 200 µM 1.28520262348855 0.0994625478375163 no 365 0.0993607435557611 484 45596039 SGTC_904 1141-0088 396 µM 1.28188246244101 0.100045375001061 no 366 0.0999419404589737 547 1378119 SGTC_2314 7727897 200 µM 1.28155298456098 0.100103347882053 no 367 0.0999997509652185 537 900724 SGTC_7 0192-1582 4.227 µM 1.28141360466531 0.100127879683628 no 368 0.100024214044618 670 252616 SGTC_1302 1159-0335 255 µM 1.28087782559947 0.100222221276058 no 369 0.100118291288501 535 649284 SGTC_252 miconazole 1.30953 nM 1.27950515570332 0.100464221161342 no 370 0.100359612613022 546 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_1989 st071868 50.2 µM 1.2789194987155 0.100567601371993 no 371 0.100462702743629 573 16414057 SGTC_818 4072-2707 53.5 µM 1.27538323717903 0.101193471846965 no 372 0.10108681445206 529 882871 SGTC_509 pifithrin 175 µM 1.27092057508269 0.101987347591298 no 373 0.101878452948347 553 4817 A p53 inhibitor. SGTC_3340 9146634 11.102 µM 1.27043174049883 0.102074582426672 no 374 0.101965441514096 566 4907387 SGTC_381 3461-2219 42.7 µM 1.26795348343721 0.102517674453474 no 375 0.102407281358892 614 2883159 SGTC_981 1488-1094 54.9 µM 1.26344824847946 0.103326752091579 no 376 0.103214066959541 503 3449522 SGTC_2279 7948423 32.93 µM 1.25986288057776 0.103973939324593 no 377 0.10385941564755 533 1247112 SGTC_1625 st003711 30.1 µM 1.25955120504675 0.104030337787435 no 378 0.103915653678441 557 24207034 YER133W GLC7 SGTC_1389 3405-0187 19 µM 1.25715534303207 0.104464615749801 no 379 0.10434869514663 523 799890 SGTC_1647 st011722 22.4 µM 1.25587688428355 0.104696888081412 no 380 0.10458030531809 537 2854783 SGTC_1204 4049-0315 18.3 µM 1.255830552865 0.104705312661611 no 381 0.104588705870804 582 588402 SGTC_1208 2323-2347 50.3 µM 1.25546289459746 0.104772182468776 no 382 0.104655384934002 587 5412760 SGTC_1677 st019204 53.9 µM 1.25472708684205 0.104906104296324 no 383 0.104788924611663 551 3945625 SGTC_881 0833-0569 170 µM 1.24833016196423 0.10607561134363 no 384 0.105955086443478 599 5418700 SGTC_461 N-acetylfarnesylcysteine 136 µM 1.24823920680418 0.10609230771525 no 385 0.105971734954407 510 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ). SGTC_2961 9083290 32.55 µM 1.24661004575561 0.106391689663949 no 386 0.10627025822742 544 17741490 SGTC_2221 6807166 181.081 µM 1.24635570119548 0.106438484162429 no 387 0.106316918428454 491 674925 SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM 1.24608525920879 0.106488256576588 no 388 0.106366547974074 512 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding. SGTC_303 1348-1668 34.2 µM 1.24564838181868 0.106568695422743 no 389 0.106446755871995 552 5380509 SGTC_1646 st011709 75.6 µM 1.24208525958732 0.107226383583934 no 390 0.107102553267681 548 5757843 SGTC_1125 tnp00248 1.32998 µM 1.24014300299833 0.107586119194952 no 391 0.107461252833661 716 24207736 SGTC_1075 aripiprazole 15.2 µM 1.23951288910463 0.107703012543844 no 392 0.107577809247466 635 60795 An atypical antipschotic. YIL048W NEO1 SGTC_2900 5328528 85.29 µM 1.23877978352379 0.107839127151732 no 393 0.10771353134413 632 795359 SGTC_2316 5844804 197.44 µM 1.23402358320978 0.108725213784604 no 394 0.108597058279922 723 776813 SGTC_2798 7813637 45.45 µM 1.23085712673993 0.109318024843217 no 395 0.109188152528687 591 956368 SGTC_126 0417-1624 672.48 µM 1.22620031951834 0.110194066166059 no 396 0.110061650547888 743 41912 YDL195W SEC31 SGTC_18 0111-0177 500 nM 1.22390290491777 0.110628107268547 no 397 0.110494428824487 716 721752 SGTC_1292 0kpi-0043 232 µM 1.22281079294767 0.110834864631342 no 398 0.110700584005137 578 3333905 SGTC_1357 1503-1303 39.5 µM 1.2227083581533 0.110854271658989 no 399 0.11071993448892 654 292895 SGTC_1301 naphtanilide LB 4.81 µM 1.22094127851942 0.111189441245668 no 400 0.111054126972844 632 67238 An a1-adrenergic receptor antagonist or alpha blocker. SGTC_3196 9111891 49.47 µM 1.22019723642315 0.111330783769215 no 401 0.111195057131106 569 18891510 SGTC_2572 astragaloside iv 100 µM 1.21938609386128 0.111485019568047 no 402 0.11134884273516 584 45006101 An anti-inflammatory agent. SGTC_3286 9117135 37.221 µM 1.21914000850041 0.11153184201994 no 403 0.111395528474246 580 3438150 SGTC_212 3807-4682 38.772 µM 1.21261628689912 0.112778239759255 no 404 0.112638279499368 764 3125501 YBL034C STU1 SGTC_1548 st061468 90.8 µM 1.21183756936789 0.112927680407147 no 405 0.11278728195578 621 390799 SGTC_772 k072-0172 35.3 µM 1.21157075055577 0.112978917064415 no 406 0.11283836832959 565 5861980 SGTC_3134 9127454 49.47 µM 1.20899787358648 0.113473832765563 no 407 0.113331831157205 610 24262820 SGTC_2299 7976368 114.88 µM 1.20857476635043 0.113555368996342 no 408 0.113413127818287 593 2979718 SGTC_1726 st035556 14.5795 µM 1.20806994951233 0.113652705979246 no 409 0.113510178727492 668 5919439 SGTC_1104 tacrolimus 29.8 µM 1.20743502704937 0.113775213894645 no 410 0.113632326470936 651 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41 SGTC_2768 sulfasalazine 50.2 µM 1.20434847306799 0.114372103548243 no 411 0.114227459358972 612 5384001 An antioxidant and salicylic acid derivative. SGTC_544 k015-0020 52.4 µM 1.20370559244176 0.114496706305472 no 412 0.11435169498625 594 3008304 SGTC_2848 9016370 25.97 µM 1.20338451785045 0.114558972967775 no 413 0.114413778134456 682 7894410 SGTC_2661 dactinomycin 12.96 µM 1.20094201006793 0.115033442706127 no 414 0.114886848381386 661 45006140 An Actinomycin D Classic transcription inhibitor. SGTC_628 1636-0253 16 µM 1.20041873296953 0.115135273487105 no 415 0.114988378546054 661 4456143 SGTC_667 1498-1044 59 µM 1.20019757575383 0.115178330390848 no 416 0.115031308313571 651 6739982 SGTC_3092 9117248 49.47 µM 1.19935843201272 0.11534180666802 no 417 0.115194301739212 662 17141857 SGTC_265 mycophenolic acid 32.932 µM 1.19898223760641 0.115415147816639 no 418 0.11526742618827 675 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1 SGTC_2958 9077254 16.72 µM 1.1989251507161 0.115426280112333 no 419 0.115278525587517 577 16457351 SGTC_1667 st014849 34.6 µM 1.19552443964604 0.116090816906757 no 420 0.115941096703848 650 5348460 SGTC_2484 5809818 12.04 µM 1.19355150969329 0.116477591830599 no 421 0.116326725813626 605 2870548 SGTC_3223 9129970 49.47 µM 1.19049642857459 0.117078314616517 no 422 0.116925666446622 665 17248386 SGTC_1622 st003707 19.4 µM 1.19046001726518 0.117085487411237 no 423 0.116932817943524 658 10140899 SGTC_850 0388-0143 75.9 µM 1.18992779705364 0.117190366922333 no 424 0.117037385991737 606 67273 SGTC_1678 st019265 80.2 µM 1.18848723111756 0.117474579181472 no 425 0.117320753755717 656 5367020 SGTC_438 sphingosine 6.67 µM 1.18827069695333 0.117517341815024 no 426 0.117363389267841 520 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes. SGTC_312 4092-0653 6.84 µM 1.18784096755495 0.117602240323755 no 427 0.11744803535165 730 1148278 SGTC_2222 6885208 172.143 µM 1.18737871777151 0.117693612107958 no 428 0.117539135397089 589 609514 SGTC_2984 9022109 38.96 µM 1.18602027347504 0.11796242323389 no 429 0.117807146678932 592 6459207 SGTC_2605 digitonin 300 nM 1.18450407212668 0.118262964165545 no 430 0.118106792646405 726 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_1065 prochlorperazine maleate 2.48 µM 1.18399599822509 0.118363795408525 no 431 0.11820732346275 651 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine. SGTC_689 0833-0039 98 µM 1.18378391979058 0.118405902007215 no 432 0.118249304580104 661 5374726 SGTC_1552 6-methylflavone 10.6 µM 1.18363281170392 0.118435909854979 no 433 0.118279222992977 578 689013 SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM 1.18024246672441 0.119110596293725 no 434 0.118951896663651 723 368090 SGTC_1262 0737-0114 49.6 µM 1.17524587852822 0.120109867594861 no 435 0.119948180107341 722 765919 SGTC_2422 chlorphenesin carbamate 384.24 µM 1.17464162452674 0.120231112040082 no 436 0.120069061483781 667 2724 A muscle relaxant with antifungal properties. SGTC_3310 9130229 44.1445 µM 1.17229704999208 0.120702370648173 no 437 0.12053890779307 631 7761258 SGTC_1721 st082152 9.2685 µM 1.17095486129169 0.120972734599664 no 438 0.120808460710122 610 5296051 SGTC_2281 7943571 200 µM 1.17085622689644 0.120992619825684 no 439 0.120828286262055 689 1244024 SGTC_1423 4048-0112 5.59 µM 1.16973988010867 0.121217841684109 no 440 0.121052832030638 647 X1423 SGTC_769 0302-0231 76 µM 1.16850620820393 0.121467076549475 no 441 0.121301318261132 747 571869 YER009W NTF2 SGTC_2815 7968870 71.43 µM 1.1665853384925 0.12185586059102 no 442 0.121688933538045 677 2977326 YHR190W ERG9 SGTC_3056 9094900 49.47 µM 1.1662316366092 0.121927545053662 no 443 0.121760402375114 622 25236784 SGTC_2497 7-hydroxyflavone 100 µM 1.1651255842162 0.122151898878804 no 444 0.121984081092811 582 5281894 SGTC_2858 9025781 8.96 µM 1.16005909661122 0.123183299413025 no 445 0.123012373084506 773 4894980 YPL153C RAD53 SGTC_1970 st070122 35.8 µM 1.15824497054965 0.123554086377353 no 446 0.12338204057136 648 102928 SGTC_2893 9048488 25.97 µM 1.1569571801942 0.123817770169161 no 447 0.123644927626381 627 6467338 SGTC_1892 st058411 7.36 µM 1.15693062274807 0.123823212128537 no 448 0.123650353137097 723 3934738 SGTC_1446 4239-0190 62 µM 1.15575894083007 0.124063471353311 no 449 0.123889885944694 701 1340085 SGTC_2404 5161160 200 µM 1.15202524568968 0.124831259335583 no 450 0.124655349690944 697 2831543 SGTC_639 0833-0042 114 µM 1.15163684884409 0.124911318553853 no 451 0.124735166306916 705 5978911 YPR085C | YHR062C ASA1 | RPP1 SGTC_1057 3448-5381 134 µM 1.15007931339984 0.125232729558986 no 452 0.125055602876415 664 5497911 SGTC_2079 5212404 121 µM 1.14889570037643 0.125477364251354 no 453 0.1252994953985 656 758462 SGTC_1407 3909-7909 12.3 µM 1.14836912817386 0.125586305790061 no 454 0.125408106292763 682 4411780 SGTC_2138 5575593 77.673 µM 1.14716679777351 0.125835301024227 no 455 0.125656345490994 623 762213 SGTC_1013 4112-3890 241 µM 1.14550543265387 0.126179925812669 no 456 0.125999923148414 676 705171 SGTC_2344 7990960 76.95 µM 1.14315290344084 0.126669046500136 no 457 0.126487556212413 632 140813 SGTC_854 0422-0053 192 µM 1.14264479452656 0.12677486195301 no 458 0.126593049613644 654 3596728 SGTC_1018 4259-0013 28.1 µM 1.14178479528431 0.126954100006758 no 459 0.126771741973187 644 6801262 SGTC_1516 st013856 110 µM 1.141444599288 0.127025051139266 no 460 0.126842477031265 632 5281404 A mutagen and neurotoxin. SGTC_2495 cafestol 54.53 µM 1.1400456897034 0.127317097163742 no 461 0.127133633289521 623 16667697 An anti-infammatory. SGTC_3054 9094397 49.47 µM 1.13921905120135 0.127489891299872 no 462 0.127305900700624 693 2598354 SGTC_681 1642-0006 26.6 µM 1.1391012777192 0.127514523025859 no 463 0.127330457325339 651 4446530 SGTC_482 fipronil 114 µM 1.13731279842232 0.127888981106905 no 464 0.12770377318064 616 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels. SGTC_993 3909-8757 62.7 µM 1.13688204484951 0.127979283049787 no 465 0.127793799527078 617 4288324 YLR208W SEC13 SGTC_3079 9117512 49.47 µM 1.13634329000837 0.128092288407349 no 466 0.127906459919837 721 7185044 SGTC_587 k089-0003 57 µM 1.13566120167971 0.128235457768659 no 467 0.128049192110919 516 9659696 SGTC_598 3937-0236 20.2 µM 1.13114956875769 0.129185241371519 no 468 0.128996072006077 738 1379313 SGTC_2328 6201408 200 µM 1.13081303760561 0.129256282444471 no 469 0.129066895645532 657 2890418 SGTC_795 0685-0265 78 µM 1.12909882746163 0.12961856911694 no 470 0.129428072952221 693 302754 SGTC_1632 st005650 90 µM 1.12884727718737 0.129671791682251 no 471 0.129481132469886 655 2759605 SGTC_1391 3442-0225 151 µM 1.12755493516965 0.129945461759321 no 472 0.129753963860259 631 5227075 SGTC_1374 2889-5571 141 µM 1.12718864133312 0.13002310187119 no 473 0.129831365946728 724 2853281 SGTC_394 menadione 8.33 µM 1.126524089862 0.130164043011155 no 474 0.129971874894364 711 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_2465 5809242 33.21 µM 1.12629019471555 0.13021367371542 no 475 0.130021353376222 676 2731748 SGTC_516 3992-2719 87.3 µM 1.12622718257645 0.130227046632717 no 476 0.130034685274654 620 5350887 YDR037W KRS1 SGTC_2177 5811945 192 µM 1.12521347165015 0.130442314723917 no 477 0.130249292910593 673 5343475 SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM 1.12346698730617 0.13081376901754 no 478 0.130619606847694 708 4213774 SGTC_1122 capsaicin 818.572 nM 1.12311461267933 0.130888803022219 no 479 0.130694410390527 694 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_1770 st043884 66.3 µM 1.1230247664865 0.130907939462933 no 480 0.130713488049113 685 670149 SGTC_379 3970-0972 5.9 µM 1.12248330489677 0.13102330690593 no 481 0.130828501063262 678 2898042 YBL034C STU1 SGTC_2758 dehydroepiandrosterone 69.35 µM 1.12079544625878 0.131383384095374 no 482 0.131187471479614 705 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem] SGTC_1932 st074806 40.9 µM 1.11966457601405 0.131625018768651 no 483 0.131428362970026 741 17251235 SGTC_985 1493-0307 8.71 µM 1.11963361972697 0.131631637552966 no 484 0.131434961392034 627 3278274 SGTC_2992 9074591 71.4286 µM 1.11833844893187 0.131908764739727 no 485 0.131711235761846 664 17741321 SGTC_2516 gossypol 71.55 µM 1.11716337022304 0.132160543842277 no 486 0.131962239628443 730 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_3309 9129340 25.759 µM 1.11708764658266 0.132176780180055 no 487 0.131978425960212 735 17158987 SGTC_1929 genistein trimethyl ether 50.5 µM 1.11683971040162 0.132229951213913 no 488 0.132031433221862 693 136420 SGTC_2956 9076196 2.52 µM 1.11559756104127 0.132496557728407 no 489 0.132297218291804 684 16423868 SGTC_2395 5646831 180.19 µM 1.11443820665528 0.1327457276555 no 490 0.13254562009397 705 6808628 SGTC_1311 1190-0148 100 µM 1.11241007096965 0.13318239285543 no 491 0.132980938233942 816 1961333 SGTC_2408 sulbentine 18.36 µM 1.11046466791803 0.133602173276036 no 492 0.133399422565571 683 67686 An antifungal agent of unknown mechanism. YDL205C HEM3 SGTC_3156 9099931 49.47 µM 1.1035468905719 0.135102261243338 no 493 0.134894870141603 732 18111053 SGTC_2867 9039098 71.43 µM 1.103399354867 0.135134378968506 no 494 0.134926888364759 690 6463460 SGTC_3055 9094636 49.47 µM 1.09874626282522 0.136150018930764 no 495 0.135939378672163 668 25236176 SGTC_3350 9150499 3.57 µM 1.09856300626474 0.136190125361949 no 496 0.135979360602279 770 4910996 YPR165W RHO1 SGTC_962 1254-0300 21.5 µM 1.09376492985677 0.137243081219914 no 497 0.137029044455821 705 7340576 SGTC_1985 st071382 65.5 µM 1.09191590875461 0.137650336231017 no 498 0.137435032230492 715 6123237 SGTC_3273 9137859 49.47 µM 1.09149603819469 0.137742929357369 no 499 0.137527337107159 709 2377234 SGTC_1938 st074717 56.4 µM 1.08964761446707 0.138151063504922 no 500 0.137934200121754 650 17250979 SGTC_3256 9138902 49.47 µM 1.08892282042169 0.138311323719408 no 501 0.138093960949067 744 17228773 SGTC_1367 1812-0510 76.9 µM 1.08841552932735 0.138423566915077 no 502 0.138205854297559 699 1142582 YDR527W RBA50 SGTC_3302 9125395 16.351 µM 1.08786369082109 0.138545737145073 no 503 0.13832764365888 698 17599668 SGTC_2534 helenine 20.12 µM 1.08559660291366 0.139048413165539 no 504 0.13882875169873 657 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58 SGTC_2833 9001315 45.46 µM 1.0848458540921 0.139215148220486 no 505 0.138994966352953 720 2989378 SGTC_703 3875-0075 71.8 µM 1.08433690962444 0.139328257895663 no 506 0.1391077229115 774 2850814 SGTC_63 0099-0242 26.702 µM 1.08150698987641 0.139958329837636 no 507 0.13973582655009 776 3898502 YLR359W ADE13 SGTC_1430 4049-0248 69.1 µM 1.0750326454372 0.141407093679079 no 508 0.141180056407179 807 22774488 SGTC_1845 st056753 3.01 µM 1.07496949165359 0.141421275471991 no 509 0.141194193762105 730 5375839 SGTC_2791 5663188 71.43 µM 1.07448141339485 0.141530910676164 no 510 0.141303485393682 693 54690634 SGTC_2146 5545642 200 µM 1.07379071552123 0.141686157959935 no 511 0.141458246058383 731 825326 SGTC_2734 clemastine 41.6 µM 1.07244010316819 0.14199006659349 no 512 0.141761201731317 609 26987 Clemastine is a selective histamine H1 antagonist. SGTC_1152 3909-8331 15.9 µM 1.07189964526041 0.142111801505694 no 513 0.141882554786277 698 16001939 SGTC_392 N-ethylmaleimide 8.33 µM 1.06939419477956 0.142677061862138 no 514 0.142446041030242 704 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides. SGTC_615 k087-0205 167 µM 1.06753862289681 0.143096680179446 no 515 0.142864341279285 694 9642773 SGTC_2690 usnic acid 100 µM 1.06712050729479 0.143191347664715 no 516 0.142958711278876 808 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_1641 st009299 47.1 µM 1.06700242389635 0.143218091131405 no 517 0.1429853706979 665 4046054 SGTC_1875 nocodazole 6 µM 1.06683083583806 0.143256958318156 no 518 0.143024115728837 738 4122 A microtubule depolymerizer. YJL014W CCT3 SGTC_2145 5634607 200 µM 1.06483595063242 0.14370935163304 no 519 0.143475086651735 668 308662 SGTC_1753 st043925 64 µM 1.06443879058736 0.143799533187906 no 520 0.143564984538782 761 670181 SGTC_541 4513-1321 94 µM 1.06415545110946 0.143863893289494 no 521 0.143629142169413 708 747515 SGTC_2116 5511452 16.8835 µM 1.06074165475558 0.144640859057495 no 522 0.144403662040971 761 870744 SGTC_1042 0350-0096 82 µM 1.06068562208393 0.144653635392636 no 523 0.144416398131004 713 3122515 SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM 1.0578019666753 0.145312180757182 no 524 0.145072868008056 682 521171 SGTC_3057 9095946 49.47 µM 1.05421078808661 0.146135120300455 no 525 0.145893210986681 772 24540043 SGTC_579 4491-1009 110 µM 1.05402386577529 0.146178040183502 no 526 0.145935995358032 954 1271041 SGTC_1288 0973-0013 65.5 µM 1.05271215723613 0.146479464307705 no 527 0.146236467542528 772 4315430 SGTC_1725 st036284 20.55 µM 1.05247300342093 0.146534465607089 no 528 0.146291295093365 823 707914 SGTC_3280 9140961 49.47 µM 1.05001906763596 0.147099629802476 no 529 0.146854673110803 715 4901226 SGTC_3130 9127414 49.47 µM 1.04676442008134 0.147851457159306 no 530 0.147604122026128 753 1494646 SGTC_463 ikarugamyin 104 µM 1.04594549153437 0.148041035000631 no 531 0.147793099714752 718 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis. SGTC_2673 kobusone 100 µM 1.04566666325513 0.148105619455071 no 532 0.147857479674269 779 6710676 An epoxy ketone and protein crosslinker. SGTC_2624 nerol 100 µM 1.04524130432324 0.148204180837621 no 533 0.14795572894317 735 637566 A natural product oil. SGTC_1904 st060225 78 µM 1.04414842218611 0.148457617507235 no 534 0.148208362852158 751 66595 SGTC_1743 st037606 46.3785 µM 1.0430143677795 0.148720908163382 no 535 0.14847081922469 743 590142 YLR208W | YDL195W SEC13 | SEC31 SGTC_420 mitomycin C 81.9 mM 1.04248701227509 0.148843449260327 no 536 0.148592971920799 755 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_3145 9085516 49.47 µM 1.04149022907897 0.149075255073984 no 537 0.148824042827213 725 25236195 SGTC_2844 9010103 25.97 µM 1.03888737906303 0.149681694399033 no 538 0.149428558380879 735 2480525 SGTC_2039 Aminomethylbenzodioxan 200 µM 1.03742225515788 0.150023777351594 no 539 0.149769555441161 712 15053 SGTC_2172 5754775 163.918 µM 1.03720230184347 0.150075177891571 no 540 0.149820792772906 686 2263357 SGTC_1473 k844-0725 134 µM 1.0359945533904 0.15035762391277 no 541 0.15010234175712 839 54682906 SGTC_662 k832-1615 104 µM 1.03132458280043 0.151453081623624 no 542 0.151194317050162 753 5878478 SGTC_2419 paclitaxel 166.5 µM 1.02717779872629 0.152430250386514 no 543 0.15216837509232 796 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_735 3076-0345 636 µM 1.02510570414756 0.152920093347534 no 544 0.152656657175272 820 2888990 SGTC_3324 9138759 60.749 µM 1.02485734917581 0.152978874406777 no 545 0.152715250862391 768 45595710 SGTC_71 0417-1750 47.813 µM 1.02403105704092 0.153174550388661 no 546 0.152910302999138 817 6811472 SGTC_28 pentachloropyridine N-oxide 1.606 µM 1.0221541910489 0.153619631003975 no 547 0.153353964042145 749 140250 A respiratory chain inhibitor. SGTC_2957 9076800 11.52 µM 1.01732555663876 0.154768626770444 no 548 0.154499291398903 700 16459615 SGTC_2400 5203494 178.7 µM 1.01380166021151 0.155610728780079 no 549 0.155338701477382 716 6777674 SGTC_2990 9074105 71.4286 µM 1.01360052987868 0.155658883693976 no 550 0.155386702371193 760 6502001 SGTC_2580 diallyl disulphide 81.36 µM 1.01314157521384 0.155768804077994 no 551 0.15549627114876 741 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.  SGTC_479 n-linoleoylglycine 10 µM 1.01160709966308 0.15613668500053 no 552 0.155862974975482 738 6433346 An anti-infammatory. SGTC_346 4513-0042 7.16 µM 1.01097536713305 0.156288305150962 no 553 0.156014109839952 810 2827372 SGTC_260 nsc-65238 3.989 µM 1.00981647987681 0.156566698127398 no 554 0.156291611542562 769 3246252 SGTC_256 clotrimazole 625 nM 1.00799405072478 0.157005150041028 no 555 0.156728659154586 780 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C SGTC_2732 terfenadine 20 µM 1.00728661479874 0.157175567006151 no 556 0.156898530100749 754 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.  SGTC_647 0140-0236 81 µM 1.00557074872189 0.157589413707979 no 557 0.157311050375652 889 990837 SGTC_3154 9100113 49.47 µM 1.00447238565493 0.157854701450755 no 558 0.157575487503604 775 25237525 SGTC_375 3970-0961 9.27 µM 1.00443734213631 0.157863170340388 no 559 0.157583929234401 808 2898222 SGTC_1746 st038117 42 µM 1.00428381861281 0.157900275547546 no 560 0.157620915445935 768 2898218 SGTC_1268 0828-0275 2.46 µM 1.00264365315983 0.158297045668106 no 561 0.158016412814854 838 745337 SGTC_2224 6650123 117.647 µM 1.00115601614422 0.158657483108004 no 562 0.158375693549059 771 2908370 SGTC_2793 7325131 81.82 µM 1.00069847242486 0.158768448839615 no 563 0.158486303077122 765 4176441 SGTC_363 0455-0021 3.06 µM 0.999896939322326 0.158962963150863 no 564 0.15868019288335 802 4597466 SGTC_642 0335-0876 158 µM 0.999793157976214 0.158988159996194 no 565 0.158705308822006 800 6812350 SGTC_476 mead acid 10 µM 0.999286627876605 0.159111176882828 no 566 0.158827930670426 742 5312531 An omega 9 fatty acid. SGTC_2168 5727979 200 µM 0.998005173904565 0.159422671631601 no 567 0.159138424887561 724 695210 SGTC_2317 5986382 200 µM 0.997545091145738 0.159534605496784 no 568 0.159249999132478 847 877883 SGTC_1324 1418-0026 34.4 µM 0.996868961627674 0.159699194857935 no 569 0.159414059621023 826 1372513 SGTC_982 1491-0518 27.5 µM 0.992435536709846 0.160781169755374 no 570 0.160492555444353 762 3091256 SGTC_1662 st014054 52 µM 0.991745880798865 0.160949909090417 no 571 0.160660751832333 783 2838777 SGTC_2251 lansoprazole 556 µM 0.991498874844139 0.161010372579312 no 572 0.160721020745898 658 3883 Gastric proton pump inhibitor. YBR192W RIM2 SGTC_3085 9117376 49.47 µM 0.990839955711135 0.161171738972307 no 573 0.160881867790016 804 16480349 SGTC_2332 7982454 138.89 µM 0.98721853340072 0.162060492184782 no 574 0.161767759006576 824 2981748 SGTC_2305 7443522 69.23 µM 0.985728017842602 0.162427213284075 no 575 0.16213329840032 862 5415886 SGTC_1124 fisetin 1.16336 µM 0.98187504668453 0.1633776849258 no 576 0.163080705210262 762 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster. SGTC_819 1013-0258 27.7 µM 0.980361994100552 0.163751918853065 no 577 0.16345373159573 811 5753198 SGTC_996 3970-0799 1.8 µM 0.977044250045473 0.164574465936097 no 578 0.164273622982521 1011 6615648 YGL040C HEM2 SGTC_2245 6637752 200 µM 0.975182894739874 0.165037110305401 no 579 0.16473477270467 739 681890 SGTC_2627 acetyl isogambogic acid 100 µM 0.974244593023588 0.16527064638077 no 580 0.164967554049824 769 6857789 A caspase activator and apoptosis inducer. SGTC_2323 6148992 148.28 µM 0.973625353789309 0.165424887343171 no 581 0.165121296451102 744 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42 SGTC_34 0469-0683 81.75 µM 0.972419175680097 0.165725591118299 no 582 0.165421028034465 834 3690923 SGTC_589 1227-0070 34.1 µM 0.971543653401616 0.165944082641856 no 583 0.165638812988797 829 2841384 SGTC_1843 st055809 45.5 µM 0.971182675536735 0.166034220880173 no 584 0.165728659690908 777 16413835 SGTC_1209 2323-2347 50.3 µM 0.970653077505558 0.166166521783152 no 585 0.165860532645209 838 5412760 SGTC_2365 9042475 200 µM 0.968514542396586 0.166701449877614 no 586 0.166393729888528 813 6464479 SGTC_2414 st077232 92.9 µM 0.967982789163842 0.166834633684862 no 587 0.166526482623213 764 729801 SGTC_61 0978-8327 98.565 µM 0.96782421621152 0.166874363416223 no 588 0.166566083752132 869 6150059 YHR072W ERG7 SGTC_3220 9131269 49.47 µM 0.966843859665168 0.16712012277242 no 589 0.166811047497634 825 17722206 SGTC_1534 6-azauridine 81.6 µM 0.966761677194275 0.167140735169705 no 590 0.166831593157093 895 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1 SGTC_1006 4099-6547 255 µM 0.96663401539902 0.167172757604006 no 591 0.166863511908204 830 3146833 SGTC_1685 st024049 53.0905 µM 0.964270472189511 0.167766338537855 no 592 0.167455170381701 816 1941139 SGTC_1025 k007-0731 70 µM 0.961649135276341 0.168426247064282 no 593 0.168112940425667 821 6256118 SGTC_1773 st048542 73.5835 µM 0.960368749233535 0.168749183828178 no 594 0.168434830233542 817 3237138 SGTC_3348 9149464 3.537 µM 0.960174794880933 0.168798137341786 no 595 0.168483625014721 854 1951442 SGTC_688 0527-0193 473 µM 0.959858414773012 0.168878010340289 no 596 0.168563239009371 827 4007154 SGTC_2029 5175081 200 µM 0.959805281950662 0.168891426579253 no 597 0.168576611741779 873 1380876 SGTC_209 4077-0173 175.592 µM 0.958045717209839 0.169336110124594 no 598 0.169019852968036 751 15993494 SGTC_307 1501-1223 22.3 µM 0.9576003393913 0.169448786690899 no 599 0.169132163982956 830 2830329 SGTC_235 0330-0087 5 mM 0.956392246726138 0.169754665417767 no 600 0.169437050183599 885 46494818 YHR062C RPP1 SGTC_1515 3460-0031 42.1 µM 0.954468910284825 0.17024236790104 no 601 0.169923169618706 793 2876596 SGTC_1052 3253-3998 198 µM 0.95375274332875 0.170424196263076 no 602 0.170104407612176 887 5450317 SGTC_195 4234-0266 16.654 µM 0.953467688841762 0.170496603631128 no 603 0.170176579859708 892 2303354 SGTC_678 1218-2179 85.9 µM 0.953420779026662 0.170508521192199 no 604 0.170188458720827 835 6820081 YOR116C RPO31 SGTC_2356 9061756 188.97 µM 0.949835179817416 0.171421030446204 no 605 0.171098003646841 862 20104043 SGTC_2499 avocadenofuran 51.48 µM 0.947307264481151 0.172066239206822 no 606 0.17174111508739 816 6857792 A insecticide and lysyl oxidase inhibitor. SGTC_2762 leflunomide 42.06 µM 0.947230744180515 0.172085793894338 no 607 0.171760606193349 877 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1 SGTC_1447 4239-0816 81.9 µM 0.947155618221127 0.172104993639202 no 608 0.171779743509781 797 1341554 SGTC_736 0958-0254 92.6 µM 0.946813876074968 0.17219234904007 no 609 0.171866814860411 892 6812352 SGTC_2446 5162541 200 µM 0.946293736636588 0.172325360273096 no 610 0.171999393548009 815 1549321 SGTC_2007 4011539 71.82 µM 0.946065987334421 0.172383621468276 no 611 0.172057465266539 845 45595301 SGTC_2854 9024559 71.43 µM 0.945310155059491 0.172577063097703 no 612 0.172250277723963 836 3163529 SGTC_88 0180-0332 8.668 µM 0.944257952196201 0.172846585800869 no 613 0.172518923640838 893 3101745 SGTC_2510 benzyl isothiocyanate 8.31 µM 0.944004719378811 0.17291149164098 no 614 0.172583618307695 817 2346 DNA damaging agent; causes G2/M arrest. SGTC_2558 carylophyllene oxide 100 µM 0.939748093457798 0.17400482690758 no 615 0.173673394784689 919 6708694 An oxygenated terpenoid and antifungal agent. SGTC_2604 4'-hydroxychalcone 11.32 µM 0.939239872071942 0.17413565915653 no 616 0.173803800978287 813 5282362 SGTC_578 3460-0051 92 µM 0.936973423299306 0.174719875611528 no 617 0.174386114423294 979 2876744 SGTC_753 1322-0200 289 µM 0.936113765207859 0.174941792495883 no 618 0.174607308226132 889 5403907 SGTC_3227 9130768 49.47 µM 0.932682359529438 0.175829375279747 no 619 0.17549199779165 902 17720899 SGTC_1195 1502-0147 41.1 µM 0.932511779310262 0.175873572618615 no 620 0.175536051013897 908 817940 SGTC_2135 5326629 150.42 µM 0.930687911981503 0.176346576420041 no 621 0.17600751218359 821 5020077 SGTC_1155 4088-0394 48.2 µM 0.930101810845363 0.176498747274179 no 622 0.17615918664574 853 2326248 SGTC_3124 9127567 49.47 µM 0.928720875564765 0.176857611102153 no 623 0.176516879626098 847 17592030 SGTC_910 3454-3003 490 µM 0.928589554190843 0.176891761601202 no 624 0.176550918688782 890 820824 SGTC_2092 5303694 80.6725 µM 0.927812514600282 0.177093918249558 no 625 0.176752415626806 876 1963699 SGTC_2075 5212009 200 µM 0.927750186831343 0.177110139925183 no 626 0.176768584361256 803 780898 SGTC_721 1187-1332 279 µM 0.927369248371573 0.177209304898852 no 627 0.176867425686625 785 25730 SGTC_2719 novobiocin 32.65 µM 0.924252019288478 0.178022091509072 no 628 0.177677558754819 840 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication. SGTC_1236 0330-0013 258 µM 0.922755896846242 0.178413024075775 no 629 0.178067214511589 865 4617066 SGTC_291 SEC14.278 35.5 µM 0.921193991407898 0.178821722122678 no 630 0.178474577374167 910 1068044 SGTC_870 0573-2213 57.6 µM 0.920509177067479 0.179001100659942 no 631 0.178653369783665 861 3916321 SGTC_2561 acetosyringone 100 µM 0.919174119836013 0.179351127564783 no 632 0.179002252764036 992 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent. SGTC_1711 st032263 62.8 µM 0.916713899332951 0.179997277504035 no 633 0.179646290348287 862 3958979 SGTC_2453 5731132 22.18 µM 0.914695781576011 0.180528403895872 no 634 0.18017567977346 934 1362040 SGTC_380 3970-0968 6 µM 0.913102637839757 0.180948379559749 no 635 0.180594281570245 859 2891601 SGTC_3088 9117578 49.47 µM 0.909969754638666 0.181776036866173 no 636 0.181419230341664 914 678341 SGTC_3171 9103192 49.47 µM 0.908311784796431 0.18221500255473 no 637 0.181856758962903 922 13018434 SGTC_2567 aureobasidin a 60 nM 0.905086420954785 0.183070849155681 no 638 0.182709802682488 862 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1 SGTC_2696 st077691 74.316 µM 0.904718215754689 0.183168711221907 no 639 0.18280734416553 818 757133 SGTC_3279 9140807 49.47 µM 0.904408223153429 0.183251126760859 no 640 0.182889489708428 912 45595718 SGTC_762 1165-0429 115 µM 0.902735400878593 0.183696267185584 no 641 0.183333171624117 913 5967793 SGTC_287 k060-0039 29.6 µM 0.901387562039765 0.184055418700059 no 642 0.183691146112759 937 5861974 SGTC_2225 6654152 15.4 µM 0.90050069490322 0.184291975804634 no 643 0.183926927837225 869 97582 YGR029W | YLR033W ERV1 | RSC58 SGTC_521 r062-0005 13.8 µM 0.899645533509379 0.184520255003935 no 644 0.184154458695827 882 2832033 SGTC_259 usnic acid 108.925 µM 0.8963889402853 0.185391188248589 no 645 0.185022536031451 927 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_82 0054-0107 293.755 µM 0.895919734384562 0.185516881225233 no 646 0.18514781673646 933 3104697 SGTC_530 4358-1714 28 µM 0.893981354205635 0.186036703547679 no 647 0.185665933765346 951 1564641 SGTC_1084 voriconazole 435 nM 0.890226428914916 0.187046240987912 no 648 0.186672158115871 958 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_2282 7944268 200 µM 0.890221760508688 0.187047498226522 no 649 0.186673411227463 923 2970414 SGTC_1574 spiramycin 23.7 µM 0.889986932620878 0.18711074597327 no 650 0.186736451353568 947 6419898 An antibiotic and protein synthesis inhibitor. SGTC_3206 9114350 49.47 µM 0.887423769639694 0.187801959492263 no 651 0.187425395444882 845 17087243 SGTC_3239 9133757 49.47 µM 0.887317575141503 0.187830631165189 no 652 0.187453972965401 943 17036923 SGTC_1659 st012954 42.1 µM 0.886128931539331 0.188151739957469 no 653 0.187774027210097 902 24207262 SGTC_1785 bathophenanthroline 24 µM 0.884128040908709 0.188693039620926 no 654 0.188313548846175 890 72812 An iron chelator. SGTC_2301 7769476 200 µM 0.883981653883227 0.188732679257288 no 655 0.188353058259433 895 977820 SGTC_245 methotrexate 289.6 µM 0.880621882253873 0.189643870430475 no 656 0.18926125537332 955 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2 SGTC_17 0960-0276 49.807 µM 0.880597094221376 0.189650603141308 no 657 0.189267965956824 989 6821114 SGTC_2824 7998404 51.95 µM 0.879578448509377 0.189927406030527 no 658 0.189543859066003 875 837851 SGTC_1294 1000-1494 117 µM 0.879567973614242 0.189930253727992 no 659 0.189546697403251 904 712797 YDL207W GLE1 SGTC_1613 st002381 52.1 µM 0.876300601655834 0.1908197997983 no 660 0.190433319031356 996 551167 SGTC_1157 4092-0394 27.6 µM 0.876095957937305 0.190875599242015 no 661 0.190488934994245 1008 3659885 SGTC_282 k297-0036 65.7 µM 0.875594730808417 0.191012309263232 no 662 0.190625195464998 933 5061378 SGTC_1730 st033808 45.1 µM 0.873315542501621 0.191634716410485 no 663 0.191245555602054 1002 1045166 SGTC_706 4262-0057 46.9 µM 0.872412744078938 0.191881598217479 no 664 0.191491625307235 944 883298 SGTC_1378 2093-0007 380 nM 0.868043040729033 0.193079299225141 no 665 0.192685385444622 917 3618014 SGTC_371 0195-0006 7.36 µM 0.865553148478267 0.193763795778616 no 666 0.193367628956665 851 3928593 SGTC_2297 7971671 152.32 µM 0.864868674071588 0.193952223641136 no 667 0.193555436504282 946 909016 SGTC_2934 9036370 36.88 µM 0.864154225675111 0.194149022054703 no 668 0.193751587001872 976 6462800 SGTC_1008 4106-0037 6 µM 0.862635810049297 0.194567681059055 no 669 0.194168867512367 963 2905394 SGTC_2339 9000433 200 µM 0.859085755955326 0.195548646938599 no 670 0.195146602644258 880 2988954 SGTC_2458 5808907 16.39 µM 0.858729066410536 0.195647374657379 no 671 0.195245005150721 1034 2731747 SGTC_2952 9073731 13.78 µM 0.85704159977577 0.196114856841586 no 672 0.195710947290876 1008 16457353 SGTC_331 k048-0133 24.5 µM 0.853143919742292 0.197197225221529 no 673 0.196789749106907 924 6813582 SGTC_2438 5259590 200 µM 0.853063001675565 0.197219734035903 no 674 0.19681218373877 1006 1201127 SGTC_845 0330-0138 4.51 µM 0.851727981779728 0.197591318140709 no 675 0.197182543137945 989 9039800 SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM 0.851372859639068 0.197690232634047 no 676 0.197281131595788 978 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair. SGTC_308 4092-1169 104 µM 0.850445456534151 0.197948689374425 no 677 0.197538736383316 993 2268590 YDL196W YDL196W SGTC_264 promethazine 12.5 mM 0.850185372618128 0.19802120844415 no 678 0.197611016396401 1090 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3 SGTC_2444 5485484 36.41 µM 0.847113686071744 0.19887889845921 no 679 0.198465878692138 1007 6790631 SGTC_2204 7233102 200 µM 0.845031910810734 0.199461452018902 no 680 0.199046511249215 919 2172480 SGTC_401 neomycin 50 µM 0.843705944486114 0.199833038713322 no 681 0.199416872460816 952 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis. SGTC_921 1561-0023 372 µM 0.843192717013682 0.199976976458945 no 682 0.199560335471943 1041 24050882 SGTC_2962 9082311 13.18 µM 0.840612302044018 0.200701613561346 no 683 0.200282582319199 948 16459453 SGTC_21 0849-0113 22.993 µM 0.838960357514701 0.20116634224454 no 684 0.200745777846006 979 1560156 SGTC_1684 st024538 14.6195 µM 0.83762750266161 0.201541773857889 no 685 0.201119970774137 978 6732859 SGTC_2173 5763948 167 µM 0.837449095812067 0.20159205840724 no 686 0.201170089408322 1023 2867177 SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM 0.837265007696741 0.201643952117895 no 687 0.20122181189234 970 5355888 SGTC_1474 0330-0125 5.35 µM 0.836993139804392 0.201720605233347 no 688 0.201298212082198 1023 X1474 SGTC_3268 9137683 49.47 µM 0.835409880343698 0.202167351665054 no 689 0.201743484336953 965 1953228 SGTC_496 calpeptin 138 µM 0.834862748895447 0.202321872616558 no 690 0.20189749536525 927 73364 A calpain inhibitor. SGTC_1147 3809-1045 12.3 µM 0.831944239137454 0.203147311235486 no 691 0.202720209730074 978 325925 SGTC_120 rhodamine 6G 52.259 µM 0.830880781702404 0.203448586665581 no 692 0.203020490723606 1109 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase SGTC_696 1560-0013 611 µM 0.830583547909535 0.203532840059656 no 693 0.203104466007093 1000 1650269 SGTC_1808 st050063 61.5 µM 0.830282022616085 0.203618331175582 no 694 0.203189674922125 987 4011993 SGTC_484 loperamide 105 µM 0.830184728334884 0.203645921478998 no 695 0.203217174150642 935 3955 An opioid-receptor agonist. SGTC_2615 purpurogallin-4-carboxylic acid 100 µM 0.829591724393421 0.203814131239012 no 696 0.203384828643859 1068 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase. SGTC_1842 st055362 61.2 µM 0.829536213911697 0.203829881417496 no 697 0.20340052682948 1033 676032 SGTC_3120 9124077 49.47 µM 0.829301138985805 0.203896588069376 no 698 0.203467013274498 1065 18774327 YGL155W CDC43 SGTC_698 k064-0052 127 µM 0.828377136394639 0.204158916130223 no 699 0.203728475330986 1019 5088751 SGTC_517 1365-0151 113 µM 0.827965706545964 0.204275787373881 no 700 0.203844960742417 964 768657 SGTC_2600 tangeritin 87.95 µM 0.826101748077755 0.204805764445448 no 701 0.204373188073313 954 68077 A bioactive flavone. SGTC_1281 0884-0031 11.8 µM 0.825153426340743 0.205075713179554 no 702 0.204642245497114 1008 1548255 SGTC_1850 st056238 17 µM 0.824108510576967 0.205373403064193 no 703 0.204938952428164 1088 5393177 SGTC_2635 hydroquinidine 100 µM 0.824022613754531 0.205397885936176 no 704 0.204963354457008 988 442912 An experimental heart treatment. SGTC_1410 3909-8106 77.9 µM 0.823897181972917 0.205433640433369 no 705 0.204998990891238 1020 1039210 SGTC_555 4296-0685 37 µM 0.820059468685313 0.206529371287584 no 706 0.206091103261606 1030 2908540 YHR072W ERG7 SGTC_2646 retinol 96.75 µM 0.819595218304863 0.206662156804919 no 707 0.206223450233252 1009 445354 A vitamin A analog and teratogen. SGTC_3209 9113616 49.47 µM 0.818528961802375 0.206967320253311 no 708 0.206527605797426 1047 16649353 SGTC_2556 citropten 84.59 µM 0.818273634157811 0.207040434778493 no 709 0.206600478835658 1060 2775 A potential DNA crosslinker. SGTC_2873 9040596 71.43 µM 0.81735499331949 0.207303619187451 no 710 0.206862793963049 1033 6463863 SGTC_361 000s-0510 1.45 µM 0.813519464544339 0.208404607604448 no 711 0.207960145552661 997 660 SGTC_3344 9148862 3.898 µM 0.812898595438107 0.208583151815575 no 712 0.208138099942185 1044 4905352 SGTC_2304 7443016 91.4 µM 0.812632149296593 0.208659801757026 no 713 0.208214496666369 945 939854 SGTC_1352 1496-0991 99 µM 0.808530215278431 0.209841920212605 no 714 0.209392709654855 1053 3000039 SGTC_342 k048-0088 23.3 µM 0.808086823036096 0.209969934825053 no 715 0.209520301305384 1035 6820570 SGTC_750 4073-0104 132 µM 0.806937066777323 0.210302102034001 no 716 0.209851371005325 872 22330957 SGTC_2247 cerulenin 830 nM 0.806259369449466 0.210498034791108 no 717 0.210046656367879 1045 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12 SGTC_1433 4060-0023 7.6 µM 0.806255614592856 0.210499120676475 no 718 0.210047738665267 1027 3840627 SGTC_656 4090-1979 187 µM 0.805063605704108 0.210844009724163 no 719 0.210391488114555 1079 22330961 SGTC_1724 st037281 8.293 µM 0.803724779738431 0.211231772835359 no 720 0.210777969921522 1023 574124 YDL195W SEC31 SGTC_5 0352-0601 109.883 µM 0.802759299196443 0.211511663325751 no 721 0.21105693553203 981 762456 SGTC_1575 cyproterone acetate 48 µM 0.799607076962404 0.212426995534764 no 722 0.211969242957238 1009 9880 An androgen receptor antagonist and liver toxin. SGTC_387 norethindrone acetate 66.7 µM 0.799446328125345 0.212473735204882 no 723 0.212015828167807 984 541197 SGTC_2887 9044784 58.44 µM 0.798606314708885 0.212718076981085 no 724 0.212259362466264 1104 6465546 SGTC_2593 nobiletin 86.24 µM 0.798440163041284 0.212766426342908 no 725 0.212307552046323 987 72344 An anti-infammatory. SGTC_1394 3474-0001 65.7 µM 0.797542699782081 0.213027694867754 no 726 0.212567957141014 948 5017666 YIL048W NEO1 SGTC_504 lovastatin 124 µM 0.797125251208694 0.213149285795152 no 727 0.212689146235379 1031 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1 SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM 0.796708166480693 0.213270811161442 no 728 0.212810269982872 968 5711223 A potent inhibitor of glutathione S-transferases. SGTC_1431 4049-0260 9.09 µM 0.796327995040055 0.213381616344824 no 729 0.212920708973631 1051 3854841 SGTC_188 3229-0966 278.469 µM 0.796015878038078 0.213472611387998 no 730 0.213011403291978 1156 5722370 SGTC_2112 5488546 200 µM 0.795298162827927 0.213681940895761 no 731 0.213220040992823 1044 600757 SGTC_709 3807-1509 243 µM 0.794937657670438 0.21378713127543 no 732 0.213324883729588 1053 1886677 YPL242C IQG1 SGTC_543 3844-1095 191 µM 0.793904384804659 0.214088792931866 no 733 0.213625548418657 1062 4230703 SGTC_2832 7992762 51.95 µM 0.793646408011096 0.214164147294738 no 734 0.213700653739716 933 2985177 SGTC_3042 9091578 49.47 µM 0.789483022946416 0.215382394108165 no 735 0.21491487424146 1014 25236497 SGTC_3175 9106517 49.47 µM 0.788924172104891 0.215546224785447 no 736 0.215078163449219 1022 41468073 SGTC_77 0828-0286 12.516 µM 0.78846860915535 0.21567982941436 no 737 0.215211326506401 1073 745345 SGTC_661 1304-0007 33.6 µM 0.788163875680695 0.215769226519353 no 738 0.215300428147888 1020 3117130 SGTC_3146 9095609 49.47 µM 0.788039661794613 0.215805672266644 no 739 0.215336753439419 1035 17173999 SGTC_2032 5185112 25.99 µM 0.78698814725088 0.21611434134236 no 740 0.215644402340392 1017 5718189 SGTC_941 3237-0776 460 µM 0.786800575225133 0.216169429433545 no 741 0.215699308360991 1047 760008 SGTC_1185 1319-0113 81.3 µM 0.785702981605216 0.216491945037577 no 742 0.216020758024018 1039 4672763 SGTC_741 4582-0002 126 µM 0.785485070840158 0.216556008787641 no 743 0.216084610037939 1036 2912688 SGTC_3141 9094609 49.47 µM 0.785319893181108 0.216604576799021 no 744 0.216133017527906 985 25236309 YDL196W YDL196W SGTC_980 1473-0395 201 µM 0.784980231290255 0.216704469078266 no 745 0.21623257965468 1005 768876 SGTC_3198 9112019 49.47 µM 0.783907864014608 0.217020019872213 no 746 0.216547087527062 1065 45595555 SGTC_903 1134-0042 114 µM 0.783720371437104 0.217075217997601 no 747 0.216602103218238 1066 701009 SGTC_1251 0490-5699 265 µM 0.783676886886991 0.217088021079998 no 748 0.216614863985435 1128 3883818 SGTC_562 3772-2733 112 µM 0.783285415692241 0.217203300923539 no 749 0.216729762820166 1110 2876874 YIL048W NEO1 SGTC_704 1310-0270 142 µM 0.781519238001468 0.217723841712216 no 750 0.217248583187185 1101 5718033 SGTC_1624 st003710 6.25 µM 0.781204644520528 0.217816636457809 no 751 0.21734107124137 1109 24207033 SGTC_2378 9074213 121.43 µM 0.780206716140838 0.218111143464335 no 752 0.2176346048906 1093 657714 SGTC_2838 9002687 71.43 µM 0.778745528943724 0.218542780456116 no 753 0.218064815316722 1005 6457060 SGTC_3077 9117319 49.47 µM 0.778664547324197 0.218566716929399 no 754 0.218088672680131 1088 17154678 SGTC_1461 k072-0203 53.8 µM 0.778623481925788 0.218578855579193 no 755 0.218100771211793 1038 5418714 SGTC_2949 9072542 2.23 µM 0.77841709408073 0.218639868285928 no 756 0.21816158227228 1117 16457352 SGTC_3301 9125354 19.7965 µM 0.77604584694228 0.219341563210754 no 757 0.218860958132566 1012 41905162 SGTC_2813 7971799 71.43 µM 0.775143130620261 0.219609033037277 no 758 0.219127544001402 1040 2234054 SGTC_1626 st003712 1.76 µM 0.77371368683819 0.220032952184802 no 759 0.219550062164983 1005 24207035 SGTC_1267 0828-0272 9.49 µM 0.773523882408857 0.220089276309731 no 760 0.219606200149932 1092 745334 SGTC_966 1300-0360 30.2 µM 0.77288631200628 0.220278534725014 no 761 0.219794833107825 1047 70588 SGTC_1090 efavirenz 20.7 µM 0.772634402984462 0.220353337905839 no 762 0.219869389082297 1071 64139 A non-nucleoside reverse transcriptase inhibitor. SGTC_231 b-estradiol 524 µM 0.772429355637494 0.220414236485084 no 763 0.219930086407249 1036 450 A steroid. SGTC_157 1348-1695 65.819 µM 0.772320184908912 0.220446663869294 no 764 0.219962406627483 1068 5380510 SGTC_302 1094-0063 18.9 µM 0.772190210744351 0.220485274139979 no 765 0.220000889301628 1029 5440289 SGTC_2911 7942208 15.64 µM 0.772161552869073 0.220493787801863 no 766 0.22000937482819 1050 1243384 SGTC_3275 9138069 49.47 µM 0.77118758826625 0.220783244514504 no 767 0.220297874973692 1068 17617007 SGTC_2945 9067681 61.76 µM 0.770172408848421 0.221085181510859 no 768 0.220598814176842 1135 16456930 SGTC_2927 9011802 47.9 µM 0.769555674815524 0.221268727281382 no 769 0.220781753403855 1052 43912568 SGTC_2727 riluzole 51.77 µM 0.769001905959029 0.221433608269604 no 770 0.220946089534277 1085 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.  SGTC_1973 st070275 50.2 µM 0.76875488052694 0.221507181097141 no 771 0.221019419238545 1056 17118334 SGTC_2846 9008642 19.48 µM 0.768345359915186 0.221629181461467 no 772 0.221141016452324 1040 2992898 SGTC_433 pimozide 108 µM 0.767436684369245 0.221900022253538 no 773 0.221410962262833 1051 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic SGTC_1272 0839-0021 27 µM 0.765559004225703 0.222460284003145 no 774 0.221969372710459 1088 5027250 SGTC_853 0419-0306 21 µM 0.765422222627334 0.222501128363393 no 775 0.222010082109813 1046 762713 SGTC_470 aa-861 153 µM 0.764371834923403 0.222814927166583 no 776 0.222322844051741 1110 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor. SGTC_2628 lathosterol 100 µM 0.763354128463656 0.223119202968053 no 777 0.222626114485163 1145 6710616 SGTC_2681 menadione 3.18 µM 0.762751597001817 0.223299460405921 no 778 0.22280577634139 1113 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_1277 0873-0036 22 µM 0.761180761254467 0.223769791876989 no 779 0.223274553856503 1129 5965735 SGTC_2924 9010168 62.78 µM 0.760525823785044 0.223966056070435 no 780 0.223470169622469 1123 2993929 SGTC_566 0958-0068 16.5 µM 0.758727694048606 0.224505401676655 no 781 0.224007733380082 1065 6815365 SGTC_3087 9117406 49.47 µM 0.756402264012407 0.225204001619015 no 782 0.224704025499986 1097 42546093 SGTC_325 2810-4341 181 µM 0.755729489112005 0.225406344410264 no 783 0.224905699887868 1116 774970 SGTC_1380 2291-0730 164 µM 0.755430149449863 0.225496406443117 no 784 0.224995464422136 1090 2999191 SGTC_1494 4358-1428 177 µM 0.752029570641896 0.226520964194692 no 785 0.226016638030707 1154 1564571 SGTC_1282 0886-0010 32.4 µM 0.749607654879723 0.227252260930442 no 786 0.226745519560892 1182 2836211 YNL267W PIK1 SGTC_2939 9044578 71.43 µM 0.749520669363736 0.227278550908166 no 787 0.226771722717166 1107 2653634 SGTC_423 5-fluorouracil 457 µM 0.746110138160802 0.228310679253396 no 788 0.227800442779188 1095 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_931 2812-0076 566 µM 0.746104493931408 0.228312389545995 no 789 0.227802147424533 1159 3450959 SGTC_2726 cimetidine 79.27 µM 0.743258720996263 0.229175621222599 no 790 0.228662528979867 1135 2756 A P450 inhibitor, histamine H2-receptor antagonist. SGTC_2511 berberine 10.47 µM 0.742085283544153 0.229532101925846 no 791 0.229017832817178 1111 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_787 4152-0075 138 µM 0.74033444458211 0.230064569649231 no 792 0.229548542819394 1086 9566539 SGTC_1299 1079-1439 3.74 µM 0.739790551016232 0.230230119956935 no 793 0.229713546666208 1114 323161 SGTC_2942 9052777 62.25 µM 0.739633649862096 0.230277889905739 no 794 0.229761158935494 1186 6469503 SGTC_1817 st052116 64.4 µM 0.739420301144306 0.230342854708461 no 795 0.229825909304009 1116 4361398 SGTC_1853 st056710 91.2 µM 0.739258208988221 0.230392218709604 no 796 0.229875110367428 1176 269167 SGTC_526 4469-0568 170 µM 0.739108396391295 0.23043784831823 no 797 0.229920589365932 1152 2901964 SGTC_2563 tomatine 8.54 µM 0.738920928319169 0.230494954068515 no 798 0.229977506628501 1127 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties. SGTC_894 0960-0238 55.9 µM 0.738174668719729 0.230722354984009 no 799 0.230204156986995 1126 6741907 YDL195W SEC31 SGTC_3353 9151644 39.2805 µM 0.737334447580481 0.230978537865867 no 800 0.230459494353729 1123 4909158 SGTC_1584 6-fluoro-dl-tryptophan 90 µM 0.736318640037371 0.2312884688572 no 801 0.230768402494435 1159 94937 An inhibitor of serotonin biosynthesis. SGTC_882 0843-0131 351 µM 0.735614348583224 0.231503489905503 no 802 0.230982713956003 1173 5425421 SGTC_3099 9120367 49.47 µM 0.734365133725319 0.231885150735065 no 803 0.231363115350438 1165 24824940 SGTC_1839 st053978 48 µM 0.733319419479872 0.232204907219053 no 804 0.231681816752809 1185 3788398 SGTC_2540 epiandrosterone 100 µM 0.732093761397875 0.232579998722762 no 805 0.232055670680143 1240 441302 A steroid. SGTC_343 4130-2827 29.8 µM 0.7318159344026 0.232665069689113 no 806 0.232140460977342 1148 1118244 SGTC_3298 9116858 71.43 µM 0.731743824485267 0.232687152660957 no 807 0.232162471093109 1145 2506942 SGTC_2405 ticlatone 3.52 µM 0.730975003409361 0.232922669164299 no 808 0.232397210602924 1088 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W SGTC_2076 5212012 200 µM 0.730342701278638 0.233116464380812 no 809 0.232590366499018 1059 604802 SGTC_2352 9027995 87.8 µM 0.729318720697597 0.233430495494378 no 810 0.232903361698911 1092 2997347 SGTC_2136 5328288 199.296 µM 0.727836436507804 0.233885493143858 no 811 0.233356858551057 1080 262395 SGTC_2189 6047310 154.431 µM 0.727433187621712 0.234009358224213 no 812 0.233480315093171 1110 711535 SGTC_2244 6635614 200 µM 0.727327225169529 0.234041912506932 no 813 0.233512762005628 1010 836499 SGTC_677 0929-0063 136 µM 0.727156659199608 0.234094319854218 no 814 0.233564996505163 1101 1539583 SGTC_1968 st069590 43.6 µM 0.726604916055809 0.234263890522665 no 815 0.233734007917266 1115 6384066 SGTC_1072 oxiconazole 14.9 nM 0.726193676710082 0.234390323493905 no 816 0.233860023918055 1136 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_2582 agaric acid 100 µM 0.725733955587387 0.234531706573511 no 817 0.234000940737329 1125 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase. SGTC_1930 st074634 34.3 µM 0.724823867033891 0.234811735173216 no 818 0.234280045891408 1142 684253 YOR116C RPO31 SGTC_1470 k295-0292 231 µM 0.724249750683888 0.234988482236755 no 819 0.234456210131583 1161 5045612 SGTC_1600 coumarin 106 71.1 µM 0.723811126083546 0.235123566420725 no 820 0.23459084889263 1167 100336 A hepatotoxic, DNA x-linker. SGTC_668 1682-0499 62.6 µM 0.72226372198753 0.23560046624578 no 821 0.235066176321287 1185 682214 SGTC_1108 betulinic acid 729.144 nM 0.721670229970665 0.235783518079628 no 822 0.235248624661492 1179 64945 Apoptosis-inducing agent of unknown mechanism. SGTC_560 2332-1943 155 µM 0.721495433111894 0.235837445941345 no 823 0.235302374736765 1156 21177716 SGTC_12 0849-0099 9.267 µM 0.71946932278687 0.23646303205626 no 824 0.235925898635279 1110 6071388 SGTC_2417 cerulenin 830 nM 0.718382976126678 0.236798830522593 no 825 0.236260590297495 1161 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1 SGTC_963 1269-2853 151 µM 0.717467003263902 0.237082168725743 no 826 0.236542994685253 1155 3668223 SGTC_1964 st076914 61 µM 0.7173728419517 0.237111306233124 no 827 0.236572036166409 1184 24208661 SGTC_2823 7987624 58.44 µM 0.715926858935873 0.237559001783231 no 828 0.237018256377663 1169 2239440 SGTC_3285 9112818 20.8695 µM 0.715360818200445 0.237734381777785 no 829 0.2371930584738 1216 17017947 YPR165W RHO1 SGTC_912 3474-0017 2.18 µM 0.714528957526499 0.237992251288649 no 830 0.237450078325005 1187 3360550 SGTC_2061 5245884 80.95 µM 0.712724908328006 0.238552017181808 no 831 0.238008000048849 1174 573863 SGTC_548 1436-0017 110 µM 0.710673500509432 0.239189408944269 no 832 0.238643292266732 1223 9677137 SGTC_2097 5376186 200 µM 0.710492849403018 0.239245583498574 no 833 0.238699281803176 1129 742755 SGTC_1401 3807-4679 7.6 µM 0.710072913382264 0.239376192993028 no 834 0.238829461131103 1149 3291456 SGTC_636 0kpi-0074 126 µM 0.707956636005823 0.240034994865358 no 835 0.239486093478131 1144 616434 SGTC_2614 arthonioic acid 13.39 µM 0.707017495074873 0.240327667915819 no 836 0.239777802856953 1140 6710684 SGTC_1183 1254-0324 198 µM 0.706160504425689 0.240594909284125 no 837 0.240044164368385 1201 5799357 SGTC_313 3474-0040 5.03 µM 0.705252869968548 0.240878119579537 no 838 0.240326442312423 1167 1043375 YIL048W NEO1 SGTC_2437 5741531 144.16 µM 0.705195805451219 0.240895931548559 no 839 0.240344195645799 1238 2262990 SGTC_1601 4'-hydroxyflavanone 55.5 µM 0.703233575501451 0.241508852561611 no 840 0.240955099174431 1202 165506 SGTC_1348 1493-0373 93.8 µM 0.702493480648604 0.241740247932161 no 841 0.241185732991027 1172 3010129 SGTC_1741 st038134 10.228 µM 0.702069771778231 0.241872777355254 no 842 0.241317826267721 1224 1272587 SGTC_1672 st016598 6.51 µM 0.701789706775801 0.24196039888668 no 843 0.241405159452446 1148 4665860 YNL267W PIK1 SGTC_132 0417-1715 25.805 µM 0.700897400682768 0.242239681810561 no 844 0.24168352336263 1220 6769098 SGTC_35 0133-0054 64.071 µM 0.700141619787236 0.24247637031163 no 845 0.241919433079457 1146 99677 SGTC_2119 5528445 120.635 µM 0.698836783498314 0.242885301590363 no 846 0.242327018985053 1182 791935 SGTC_1650 st011916 45.8 µM 0.697665034815873 0.243252841437828 no 847 0.242693349797304 1182 242528 SGTC_618 k072-0232 33.2 µM 0.697156392588176 0.243412479659709 no 848 0.242852462931708 1176 5872756 YGL099W LSG1 SGTC_1320 1313-0481 95.3 µM 0.696060102917565 0.243756744418898 no 849 0.243195595423556 1221 6813365 YLR208W SEC13 SGTC_1224 0823-0416 294 µM 0.695861439612545 0.243819158215653 no 850 0.243257803959589 1216 3598164 SGTC_451 chloral hydrate 100 µM 0.695488203394339 0.243936440682189 no 851 0.243374700730699 1260 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1 SGTC_2521 angolensin 13.4 µM 0.694554387495561 0.244230008076512 no 852 0.243667302769294 1217 821428 A flavenoid. SGTC_248 streptozotocin 5.23457 mM 0.694360341381435 0.244291035013288 no 853 0.243728129040203 1230 5300 DNA alkylating agent. SGTC_580 1123-0028 41 µM 0.694339928238479 0.244297455364988 no 854 0.243734528281065 1259 1677248 YPR107C YTH1 SGTC_329 k048-0121 21.3 µM 0.694281799677591 0.244315738486617 no 855 0.243752751286002 1202 6832902 SGTC_1582 3',3',6'-trihydroxyflavone 74 µM 0.694165615738037 0.244352283922028 no 856 0.243789176557635 1170 688803 SGTC_2071 5230951 39.92 µM 0.693995760300459 0.244405716925776 no 857 0.243842433873033 1250 1799272 SGTC_1596 piperlongumine 63 µM 0.692085248429803 0.24500715786042 no 858 0.244441897498388 1214 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_3003 9075612 71.4286 µM 0.691795576260801 0.24509841791255 no 859 0.244532857560262 1195 6501993 SGTC_3322 9139058 2.11 µM 0.691458830192935 0.245204531383829 no 860 0.24463862222783 1231 4908926 YPR165W RHO1 SGTC_1914 st062367 72.6 µM 0.690298429303893 0.245570379338334 no 861 0.245003267715649 1192 978205 SGTC_2265 7929201 200 µM 0.689962814203088 0.245676245769097 no 862 0.245108786216052 1213 1265108 SGTC_1177 0983-0204 23.6 µM 0.689535482322659 0.24581107880392 no 863 0.245243176141782 1234 766818 SGTC_1883 5-benzylidenerhodanine 20 µM 0.688885499239307 0.246016239549759 no 864 0.245447662700175 1203 1273210 SGTC_1297 1068-0111 14.1 µM 0.687570659997521 0.246431536303934 no 865 0.245861594891624 1186 767057 SGTC_1144 3486-0183 12.5 µM 0.687344120011479 0.246503127704086 no 866 0.245932951082102 1221 6744069 SGTC_2027 5150920 200 µM 0.686382602995941 0.246807111283389 no 867 0.246235936012465 1198 786715 SGTC_1508 1080-0625 72.9 µM 0.686231221290431 0.246854988883911 no 868 0.246283656335935 1158 767111 SGTC_3232 9132874 49.47 µM 0.685437687062324 0.247106041834331 no 869 0.246533884630212 1188 3784940 SGTC_1364 1653-0028 37.6 µM 0.683946807619335 0.24757808520208 no 870 0.247004377655951 1183 5718652 SGTC_2303 7774051 200 µM 0.681748173988809 0.248275096302482 no 871 0.247699100083391 1208 2953184 SGTC_1545 lovastatin 49.4 µM 0.680617133217761 0.248634066118898 no 872 0.248056891456044 1266 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12 SGTC_2242 6630449 61.2675 µM 0.680539820723269 0.248658613655431 no 873 0.248081358413058 1192 691249 YDR170C SEC7 SGTC_2016 5121758 140 µM 0.680163737038007 0.24877804262176 no 874 0.248200395354584 1219 2795203 SGTC_1264 0783-0040 158 µM 0.679809859136126 0.24889044781278 no 875 0.248312431593969 1165 2855798 SGTC_134 0269-0018 6.916 µM 0.679727308040631 0.248916673094178 no 876 0.248338570797647 1150 4378915 SGTC_1000 4048-0884 8.67 µM 0.67632228602185 0.249999679274407 no 877 0.249418023115356 1223 13040088 SGTC_1606 st000094 49.2 µM 0.673884101102571 0.250776705340833 no 878 0.250192500397342 1266 1242210 SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM 0.673696008125042 0.250836701846532 no 879 0.25025230013949 1261 364106 SGTC_2975 9084847 53.72 µM 0.672569032397681 0.251196335322298 no 880 0.250610754275689 1239 27211724 SGTC_2877 9040724 71.43 µM 0.672554566920884 0.251200953227056 no 881 0.250615357038248 1232 6463895 SGTC_2486 5283202 22.39 µM 0.671477889399785 0.251544793730535 no 882 0.250958070169045 1207 1377751 SGTC_2470 5664817 21.68 µM 0.670843222711035 0.251747593052131 no 883 0.251160204639864 1265 2859561 SGTC_215 1287-0124 461.5 µM 0.669647723725317 0.252129833248564 no 884 0.251541191876641 1238 5560863 SGTC_2249 haloperidol 116.36 µM 0.66857955045341 0.252471622027608 no 885 0.251881860476511 1252 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_2830 7992007 71.43 µM 0.665455397674062 0.253472672572961 no 886 0.252879631186598 1187 1952075 SGTC_602 3130-1533 38.1 µM 0.664477755425 0.253786359594939 no 887 0.253192290760467 1257 720941 SGTC_285 1486-1325 46 µM 0.663360708416789 0.254145025452048 no 888 0.25354978203216 1257 22310230 SGTC_2601 securinine 100 µM 0.662966688544413 0.254271602302 no 889 0.253675944406583 1225 442872 A GABA receptor antagonist. SGTC_196 k015-0023 18.111 µM 0.662005605635638 0.254580483801039 no 890 0.253983814579111 1240 5211998 SGTC_719 2810-4230 27.3 µM 0.659308245609329 0.25544843449778 no 891 0.254848924274961 1229 721079 SGTC_2430 5571206 200 µM 0.659264315556008 0.255462583000889 no 892 0.254863026476724 1289 1731771 SGTC_693 4161-2696 114 µM 0.658166858727104 0.255816172534331 no 893 0.255215458983697 1278 805759 SGTC_350 k064-0020 19.8 µM 0.657213659184526 0.256123490992416 no 894 0.255521771988998 1256 2790705 SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM 0.6570700154896 0.256169819451252 no 895 0.255567948888473 1282 279621 SGTC_1187 1391-0724 117 µM 0.65665508041787 0.256303670276923 no 896 0.255701361852929 1284 6997986 SGTC_1021 4476-0760 85.3 µM 0.655503842386791 0.256675230406271 no 897 0.256071706665142 1229 746768 SGTC_1136 pergolide 1.05886 µM 0.655465934542157 0.256687469866953 no 898 0.256083906096252 1247 47811 A dopamine receptor agonist. SGTC_213 1246-0773 967 nM 0.653070239137919 0.257461593837962 no 899 0.256855498772752 1247 6251622 SGTC_802 4112-3352 742 µM 0.652376563327996 0.257685968366786 no 900 0.257079139810123 1334 704594 SGTC_1266 0828-0227 32.9 µM 0.651596399415319 0.257938439346479 no 901 0.25733078555101 1236 3913820 SGTC_3226 9131256 49.47 µM 0.651159426349288 0.258079905444249 no 902 0.257471789292994 1173 17178073 SGTC_2974 9094440 9.66 µM 0.650188367791006 0.258394420905615 no 903 0.257785276940575 1346 25236134 SGTC_1656 st012921 11 µM 0.649602210707964 0.258584366972916 no 904 0.257974602359643 1221 6732821 SGTC_2364 9055074 200 µM 0.648132968210962 0.259060797232084 no 905 0.25844947615711 1244 6470630 SGTC_680 0417-1641 114 µM 0.647787714966395 0.259172818093245 no 906 0.258561131111518 1252 2835990 SGTC_3207 9114163 49.47 µM 0.646744301829707 0.259511516023119 no 907 0.258898722845713 1334 849233 SGTC_754 3474-0146 171 µM 0.646728995820483 0.259516486142699 no 908 0.25890367673425 1216 24762078 SGTC_3217 9129673 49.47 µM 0.646436119238489 0.259611597581316 no 909 0.258998477573425 1258 17248312 SGTC_1034 k072-0165 12.7 µM 0.646028149057241 0.259744115562673 no 910 0.259130562825572 1277 5835461 SGTC_2714 st079313 56.9 µM 0.643793525314278 0.260470590887216 no 911 0.259854666440375 1276 2939799 SGTC_1375 2910-0797 186 µM 0.643421067940269 0.260591778292662 no 912 0.259975458298833 1273 742508 SGTC_2766 oltipraz 83.91 µM 0.641585158842192 0.261189556586011 no 913 0.260571285871782 1301 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40 SGTC_1087 pterostilbene 9.05 µM 0.640996874851085 0.261381252836383 no 914 0.260762356699209 1331 5281727 Similar to reservatol, lowers cholesterol. SGTC_1465 k213-0056 144 µM 0.640942005531249 0.261399136052504 no 915 0.260780181573434 1220 24048857 YMR208W ERG12 SGTC_549 1661-1316 519 µM 0.640128345261471 0.261664401011782 no 916 0.26104458120512 1302 2857282 SGTC_2728 chlorpromazine 9.18 µM 0.63708135719131 0.262658988755483 no 917 0.262035925626641 1295 2726 A thorazine and dopamine antagonist. SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM 0.63410753960174 0.263631554184368 no 918 0.263005321324876 1266 6857784 SGTC_1674 st016616 23.6 µM 0.634041396997891 0.263653206509711 no 919 0.263026903102423 1261 625830 SGTC_2773 thioridazine 9.09 µM 0.633755184268834 0.26374691105568 no 920 0.263120302349651 1303 5452 An antipsychotic. SGTC_1428 4049-0204 61.7 µM 0.632202380137466 0.264255586853432 no 921 0.263627321122218 1340 X1428 SGTC_32 0928-0142 34.1 µM 0.632125354842006 0.264280832206521 no 922 0.263652484250745 1254 2244242 SGTC_923 1900-2434 73.3 µM 0.63074683906496 0.264732853910465 no 923 0.264103033919013 1268 5910570 SGTC_695 3505-6186 243 µM 0.630274671756399 0.264887770096006 no 924 0.264257445701314 1312 1819379 SGTC_640 3381-0960 37.1 µM 0.629893869521625 0.265012743326244 no 925 0.264382012055668 1337 1745025 SGTC_591 4299-0174 154 µM 0.62807311503747 0.265610699714982 no 926 0.264978022095592 1286 5509088 SGTC_1623 st003709 20.3 µM 0.628067386540406 0.265612582097503 no 927 0.264979898352059 1291 16192618 SGTC_2113 5491891 107.031 µM 0.627460285311273 0.265812113735803 no 928 0.265178780670936 1282 789979 SGTC_2694 st077685 81.9 µM 0.62711127691802 0.265926854220548 no 929 0.265293147800591 1264 2838096 SGTC_1611 st001856 99.4 µM 0.626296527481565 0.26619481001512 no 930 0.265560231792541 1254 647478 SGTC_3031 9088762 49.47 µM 0.626036660974362 0.266280303973706 no 931 0.265645447623721 1257 205253 SGTC_995 3931-2021 34.6 µM 0.625500746514468 0.266456659326119 no 932 0.265821229305886 1306 730143 SGTC_93 0109-0045 59.227 µM 0.624878308736875 0.266661561362985 no 933 0.266025464890055 1351 88733 SGTC_1159 4092-0538 61.2 µM 0.62478148533638 0.266693442087482 no 934 0.266057241928648 1338 717301 SGTC_2529 gangaleoidin 93.61 µM 0.624219205936443 0.266878620061955 no 935 0.266241817687665 1353 4565183 SGTC_950 1165-0508 94.1 µM 0.620455915220413 0.268119671306882 no 936 0.267478834705513 1276 6148369 SGTC_1884 5633444 25 µM 0.620227659266826 0.268195038472267 no 937 0.267553956979191 1319 5724239 SGTC_906 1165-0455 526 µM 0.619068398206916 0.268577975972418 no 938 0.267935650374536 1280 3252859 SGTC_1173 0443-0020 122 µM 0.618766766008886 0.268677658857894 no 939 0.2680350094552 1310 5331295 SGTC_2931 9014674 55.67 µM 0.615353220393455 0.269807055478918 no 940 0.269160738842202 1297 2996810 SGTC_2865 9030313 51.95 µM 0.615235971383793 0.269845890360002 no 941 0.269199447670967 1259 42562754 SGTC_2980 9014342 25.29 µM 0.61514959935305 0.269874500046559 no 942 0.269227964496714 1313 2996599 SGTC_1107 amlodipine 47 µM 0.614132211761276 0.270211611577984 no 943 0.269563981967456 1215 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.  SGTC_27 0485-0001 32.618 µM 0.613524333590599 0.270413132553159 no 944 0.269764849041825 1263 2054479 SGTC_914 3820-6779 408 µM 0.613371385094626 0.270463849159607 no 945 0.269815401095196 1295 2893481 SGTC_1540 guanosine 70.6 µM 0.612684052805234 0.270691822195292 no 946 0.270042634526191 1271 6802 Guanosine is a purine nucleoside SGTC_676 falcarinol 140 µM 0.612062540236615 0.270898046851189 no 947 0.270248190230289 1404 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer. SGTC_2710 st078562 53.7235 µM 0.611013471667532 0.271246317018962 no 948 0.270595330885459 1291 17250908 SGTC_2270 7924575 90.91 µM 0.610576070665995 0.271391591464384 no 949 0.270740134252619 1341 1262135 SGTC_1283 0922-0125 16.4 µM 0.610484132343913 0.271422131964068 no 950 0.270770575725075 1332 3360884 SGTC_2044 5102272 200 µM 0.609612736761513 0.271711681200131 no 951 0.271059186201003 1307 592666 SGTC_1881 5652484 16 µM 0.60944502010212 0.271767428098798 no 952 0.271114752381046 1312 2255129 SGTC_644 1498-1197 63.3 µM 0.607853508683383 0.272296709509027 no 953 0.271642318318977 1378 6741615 SGTC_2704 st078022 71.1 µM 0.60555353766061 0.273062503755339 no 954 0.272405631607565 1387 54697681 SGTC_483 fpl-64176 144 µM 0.604910054964495 0.273276947560353 no 955 0.272619380906642 1352 3423 SGTC_616 4092-0450 108 µM 0.603184413029709 0.273852437799904 no 956 0.273193007846171 1371 787165 SGTC_3323 9138564 53.9225 µM 0.602320828858553 0.274140662245759 no 957 0.273480299367948 1341 43912313 YNL103W MET4 SGTC_645 0845-0943 5.41 µM 0.597113007347417 0.275881962192013 no 958 0.275215967074272 1315 1885106 SGTC_2641 levomentholum 100 µM 0.596798706458198 0.275987226217171 no 959 0.275320890844598 1303 16666 SGTC_2871 9038510 12.99 µM 0.596453998697086 0.276102696629246 no 960 0.275435988040153 1411 4945164 SGTC_643 k048-0106 28.4 µM 0.596137003452235 0.276208904815888 no 961 0.275541852974261 1377 6763920 SGTC_712 r015-0009 80.6 µM 0.595955787195568 0.276269629716834 no 962 0.275602381631091 1346 6813872 YLR060W FRS1 SGTC_2514 salinomycin 42.74 µM 0.591952280261953 0.277612858603693 no 963 0.27694127181239 1413 23682228 A polyether potassium ionophore. SGTC_1940 st075990 51.1 µM 0.591920920093372 0.277623392931737 no 964 0.276951772130665 1434 1084979 SGTC_582 0987-0078 156 µM 0.591567259389586 0.277742206125519 no 965 0.277070201757663 1361 1625765 SGTC_1665 st014639 11.4 µM 0.591034951898325 0.277921082954265 no 966 0.277248501178 1410 981133 YIL048W NEO1 SGTC_2425 5628681 7.85 µM 0.589084960976279 0.278576838566968 no 967 0.277902140682821 1363 5714958 SGTC_3192 9110362 49.47 µM 0.588353215226364 0.278823109086073 no 968 0.278147616757577 1426 16649480 SGTC_1182 1222-0449 220 µM 0.588049713021643 0.278925284446285 no 969 0.278249462552807 1374 658318 SGTC_2809 7964133 12.99 µM 0.588033558534048 0.27893072343656 no 970 0.278254884000408 1389 1253665 SGTC_1879 gemcitabine 100 µM 0.587740909073421 0.279029263354032 no 971 0.278353106103978 1355 60750 A nucleoside analog which inhibits DNA replication. SGTC_2217 6934799 96.0675 µM 0.586831641311698 0.2793355368351 no 972 0.278658391931708 1327 675606 SGTC_2940 9060638 45.86 µM 0.586724201014288 0.279371737307281 no 973 0.278694475681599 1390 4027022 SGTC_2736 butenafine 14.65 µM 0.586512440793036 0.279443093558306 no 974 0.278765601865744 1365 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_2492 derrusnin 100 µM 0.586485674753937 0.27945211346593 no 975 0.278774592692252 1293 1715307 Part of coumarin class of compounds. SGTC_1995 st072814 61.1 µM 0.586283673830258 0.279520190468923 no 976 0.278842450214271 1297 5769371 SGTC_1123 mangostin 811.285 nM 0.586120039149433 0.279575343439858 no 977 0.278897425379665 1357 5281650 An antioxidant. SGTC_2370 9071495 200 µM 0.586066448052519 0.279593407435281 no 978 0.278915431140869 1320 21791103 SGTC_2442 5158906 48.48 µM 0.585077338219559 0.279926909198371 no 979 0.279247857912123 1437 1893835 SGTC_1802 st050112 57.9 µM 0.58450458892055 0.280120113315286 no 980 0.279440439388809 1329 4662563 SGTC_775 4577-0580 57.3 µM 0.583928268488406 0.280314587278451 no 981 0.279634286711294 1422 2006902 SGTC_3147 9097027 49.47 µM 0.58381844032247 0.280351655186729 no 982 0.279671235188564 1443 25236841 SGTC_2004 4023728 41.89 µM 0.582720456596502 0.28072236413984 no 983 0.280040749920434 1350 360084 YDR527W RBA50 SGTC_257 daunorubicin 18.5 µM 0.580714778548932 0.281400146668408 no 984 0.280716349878939 1462 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_3180 9109287 49.47 µM 0.580321829858886 0.281533029012884 no 985 0.280848804453804 1348 18891271 SGTC_720 r052-1644 49.9 µM 0.580043354162605 0.281627218672426 no 986 0.280942690928245 1348 1422863 YOR257W CDC31 SGTC_2512 diallyl trisulfide 49.23 µM 0.579904631565912 0.281674144896907 no 987 0.280989466111123 1341 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent SGTC_1528 arabinosylhypoxanthine 74.6 µM 0.579610891707145 0.281773521846068 no 988 0.28108852321343 1416 804 An inhibitor of viral and cellular DNA polymerases. SGTC_1049 3226-0134 66 µM 0.579556673618894 0.28179186655031 no 989 0.281106808877533 1380 5702385 SGTC_2695 st077686 51.995 µM 0.577434399037202 0.282510390580179 no 990 0.281823021088837 1328 2876092 SGTC_1492 4158-0558 28.5 µM 0.57651996748607 0.282820254760321 no 991 0.282131888694725 1441 3967268 SGTC_1696 st025591 34.7925 µM 0.575985524956378 0.283001431456093 no 992 0.282312482808555 1385 2787147 SGTC_3152 9099253 49.47 µM 0.574060078772271 0.283654621698104 no 993 0.282963573377856 1372 25236131 SGTC_2058 5236698 133 µM 0.572255876251738 0.284267335745477 no 994 0.283574318851145 1377 766665 SGTC_1308 1187-1617 41.4 µM 0.570922974399375 0.284720400266477 no 995 0.284025928351753 1375 2882570 SGTC_456 gingerol 170 µM 0.567846823938662 0.285767323189448 no 996 0.285069491105512 1426 442793 A herb. SGTC_48 0382-0018 55 µM 0.567297128513897 0.285954596658765 no 997 0.285256163809223 1487 762596 SGTC_3321 9137793 26.8275 µM 0.566363160779655 0.286272919973138 no 998 0.285573466166438 1369 4904192 SGTC_2143 5623677 140.463 µM 0.566089939307088 0.286366073582209 no 999 0.285666321054657 1365 5375313 SGTC_2367 9070478 135.38 µM 0.56535657343461 0.286616182432926 no 1000 0.285915627980527 1406 572802 SGTC_3084 9116877 49.47 µM 0.565039489062273 0.286724353716968 no 1001 0.286023452485762 1328 27241325 SGTC_1587 estradiol valerate 56.1 µM 0.564005977959009 0.28707706363916 no 1002 0.286375031894828 1398 13791 A steroid. SGTC_2892 9047358 58.44 µM 0.563298301283414 0.287318693360915 no 1003 0.286615887330568 1368 6466771 SGTC_764 1951-2361 146 µM 0.562380559473024 0.287632191136622 no 1004 0.286928380755703 1344 5438930 SGTC_1768 st044301 37.178 µM 0.560984210710912 0.288109489462772 no 1005 0.287404150469222 1361 3931349 SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM 0.559233970925394 0.288708281697508 no 1006 0.288001025856584 1483 1377 SGTC_1024 4507-0395 26 µM 0.558386630721016 0.288998384212842 no 1007 0.288290200047172 1428 4201836 SGTC_1265 0819-1001 68.8 µM 0.558169930455495 0.289072597551775 no 1008 0.288364175940921 1363 3106768 SGTC_2198 6589944 200 µM 0.556355677804661 0.289694276021298 no 1009 0.288983865942213 1391 5290268 SGTC_201 4262-0159 12.803 µM 0.555581343648859 0.289959803125211 no 1010 0.289248544066749 1396 1341029 SGTC_2706 st078239 82.5 µM 0.555401413273739 0.2900215194272 no 1011 0.28931006306866 1387 15434492 SGTC_1487 3970-0795 2.82 µM 0.552824117546332 0.290906209566501 no 1012 0.290191926105698 1430 3765103 SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM 0.552548552853195 0.291000875304319 no 1013 0.29028628945925 1427 66535 A nucleotide analog. SGTC_1723 st034307 2.5525 µM 0.552512339785695 0.291013316780555 no 1014 0.290298691196382 1421 867466 SGTC_2436 5633522 8.09 µM 0.551687874719811 0.291296639822211 no 1015 0.290581109397172 1436 5724242 SGTC_3104 9120930 49.47 µM 0.549176828785343 0.292160339598104 no 1016 0.291442052180976 1401 17014836 SGTC_857 0438-0306 1.35 µM 0.5477147150705 0.292663796792927 no 1017 0.291943903269739 1436 4686136 SGTC_2272 7805186 180 µM 0.545949416164905 0.293272187755602 no 1018 0.292550354327188 1401 2956062 YPR165W RHO1 SGTC_293 4049-0273 38.5 µM 0.545307817826675 0.293493452765629 no 1019 0.292770914075904 1361 1380311 SGTC_1355 1499-0035 1.68 µM 0.544684268183674 0.293708567463893 no 1020 0.29298534325014 1402 1548538 SGTC_2930 9013230 14.89 µM 0.54465017962215 0.293720329578158 no 1021 0.292997067884899 1483 2995857 SGTC_2062 5245942 200 µM 0.544069401424457 0.293920758130117 no 1022 0.293196857840071 1457 1376160 SGTC_1335 1486-0900 202 µM 0.542486711736624 0.294467270560212 no 1023 0.293741629580817 1392 X1335 SGTC_1200 1643-0193 18.4 µM 0.54145019472675 0.294825440204132 no 1024 0.294098658889531 1411 5403974 SGTC_3290 9121031 71.43 µM 0.540002890430792 0.295325893573455 no 1025 0.294597519543907 1389 17014854 SGTC_953 1188-0045 9.7 µM 0.538250666627583 0.295932305526435 no 1026 0.295202002539094 1483 6144426 SGTC_3331 9141060 1.957 µM 0.535148446445336 0.297007325837118 no 1027 0.296273605923855 1382 4906567 YPR165W RHO1 SGTC_1362 1611-0397 101 µM 0.532979071711821 0.297760144495616 no 1028 0.297024033796733 1421 27816 SGTC_3160 9100216 49.47 µM 0.532043472024683 0.298085085694493 no 1029 0.297347943574602 1411 17191039 SGTC_2216 7189485 200 µM 0.53181825528097 0.298163329378438 no 1030 0.29742593894627 1459 731273 SGTC_1852 st056254 31.4 µM 0.530370691980697 0.2986664577872 no 1031 0.297927471076398 1466 442583 SGTC_1863 st057641 20.1 µM 0.529575856722158 0.298942882102654 no 1032 0.298203018701991 1430 3921635 SGTC_2925 9010536 32.5 µM 0.527264535702723 0.299747362665761 no 1033 0.299004949136764 1525 2994177 SGTC_3067 9117431 49.47 µM 0.527029426931819 0.299829249756216 no 1034 0.299086576762646 1449 17150885 SGTC_626 0214-0009 33 µM 0.526526653873092 0.300004396823245 no 1035 0.299261168933173 1537 3437874 SGTC_759 3486-0358 89.3 µM 0.526018683476778 0.300181401443559 no 1036 0.299437612866734 1558 875103 SGTC_1393 3470-5649 58.2 µM 0.524480965787803 0.300717513852812 no 1037 0.299972027648483 1411 4108395 SGTC_404 fumagillin 50 µM 0.522166641685488 0.301525197028161 no 1038 0.300777154916963 1452 12015870 A methionine aminopeptidase binder. SGTC_1118 chelidonine 707.474 nM 0.521035247247077 0.301920400785202 no 1039 0.30117110878749 1541 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor. SGTC_274 sirtinol 40.1 µM 0.52011790253905 0.302241006255979 no 1040 0.301490700654485 1405 6836442 NAD-dependent acetyltransferase inhibitor. SGTC_1495 4469-0029 237 µM 0.518998324214082 0.302632497808548 no 1041 0.301880954927947 1433 793680 SGTC_2240 6690706 185.951 µM 0.518528725917026 0.30279677346755 no 1042 0.302044711548531 1372 805876 SGTC_3229 9132204 49.47 µM 0.516936300854883 0.303354135317178 no 1043 0.302600313010022 1494 17682924 SGTC_2531 methyl deoxycholate 70.07 µM 0.516107322010726 0.303644466065477 no 1044 0.30288972715504 1431 16667744 Haematoxylin. SGTC_78 0336-0123 156.75 µM 0.515246342089646 0.303946135699077 no 1045 0.303190444668397 1418 6765896 SGTC_2409 alverine citrate 63.97 µM 0.515139214573255 0.303983680321515 no 1046 0.303227870813754 1583 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_3264 9137442 49.47 µM 0.514990535574288 0.30403579077896 no 1047 0.303279816837051 1527 17015726 SGTC_792 4534-1957 155 µM 0.514329299651693 0.304267595376137 no 1048 0.303510890080591 1475 1717904 SGTC_2995 9067767 71.4286 µM 0.514254361650877 0.304293870802954 no 1049 0.303537082618013 1473 11673567 SGTC_1788 fluconazole 20 µM 0.512907330252218 0.304766351117401 no 1050 0.304008072802785 1440 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11 SGTC_771 0250-0039 27.3 µM 0.510730931523865 0.305530425844916 no 1051 0.304769739260316 1471 3005115 SGTC_1372 2752-0194 270 µM 0.509782156176312 0.305863780751932 no 1052 0.305102044058286 1408 823334 SGTC_3250 9135583 49.47 µM 0.509670727490963 0.305902942099644 no 1053 0.305141082066325 1531 7699353 SGTC_1898 st060199 18.6 µM 0.506724093473634 0.306939333798859 no 1054 0.306174211418556 1453 688866 SGTC_2498 4'-Methoxychalcone 54.63 µM 0.506646121386754 0.306966779196852 no 1055 0.306201570471285 1378 641818 YHR062C RPP1 SGTC_1184 1269-1718 139 µM 0.505692940356028 0.307302376832311 no 1056 0.306536112489292 1589 5403821 SGTC_774 k060-0086 136 µM 0.505114911893091 0.307505968745996 no 1057 0.306739064185995 1513 5911235 SGTC_155 k072-0202 43.6 µM 0.504622877046825 0.307679318914932 no 1058 0.306911869342828 1428 5857737 SGTC_2162 5663267 200 µM 0.503966306961506 0.307910703839832 no 1059 0.307142526947412 1538 6456493 SGTC_3020 9089140 49.47 µM 0.50234119067599 0.308483747067612 no 1060 0.307713769662564 1484 17217859 SGTC_1727 st034309 9.9045 µM 0.499083308859715 0.309633935879099 no 1061 0.308860347820036 1605 870305 SGTC_3001 9076041 71.4286 µM 0.498050787330283 0.309998855701542 no 1062 0.309224123007167 1465 16004211 SGTC_1181 1222-0449 220 µM 0.493872411730107 0.31147751092499 no 1063 0.310698144717901 1547 658318 SGTC_3052 9092717 49.47 µM 0.491919285814374 0.312169734817934 no 1064 0.311388201984609 1484 25237534 SGTC_988 1497-1057 103 µM 0.49167759087286 0.312255442161433 no 1065 0.311473641181175 1548 3533044 SGTC_3345 9148410 3.559 µM 0.489906573927579 0.31288377150532 no 1066 0.312100005474119 1577 4903596 SGTC_1334 1486-0610 236 µM 0.489705577775711 0.312955116226811 no 1067 0.312171127155507 1517 3742339 SGTC_3103 9120822 49.47 µM 0.488981954835377 0.313212028277702 no 1068 0.312427236183771 1565 17141819 SGTC_3181 9108277 49.47 µM 0.488877092619747 0.313249265644678 no 1069 0.312464357177682 1440 17097298 SGTC_768 0384-0033 77.3 µM 0.488425927230765 0.313409499608897 no 1070 0.312624090437787 1463 3965305 YMR134W ERG29 SGTC_1303 1160-0052 261 µM 0.488199882573366 0.313489793906796 no 1071 0.312704133862593 1499 3562476 SGTC_1880 MG-132 525 µM 0.48779741240871 0.313632778948029 no 1072 0.312846672213221 1563 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1 SGTC_219 mitoxanthrone 164.414 µM 0.487677161018426 0.313675505934165 no 1073 0.312889265732259 1553 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA.  YMR168C CEP3 SGTC_824 1304-0008 100 µM 0.487187994770436 0.313849339242608 no 1074 0.313062556098885 1513 768245 SGTC_3138 9097216 49.47 µM 0.484858897144615 0.314677588869997 no 1075 0.313888220242993 1478 25237486 SGTC_1092 toremifene 6.32 µM 0.484115972967427 0.314941976418954 no 1076 0.31415178297237 1499 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_1396 3511-0007 98.6 µM 0.482597421357257 0.315482684763605 no 1077 0.314690805204106 1486 X1396 SGTC_2191 5911152 200 µM 0.482554755435945 0.31549788246779 no 1078 0.314705955531351 1514 2875902 SGTC_3074 9116018 49.47 µM 0.482378214986884 0.315560769919126 no 1079 0.314768646947478 1545 17027303 SGTC_2036 5160441 105 µM 0.482330045464106 0.315577929852212 no 1080 0.314785753391344 1543 134534 YIL048W NEO1 SGTC_1197 1601-0112 267 µM 0.481393527865909 0.315911634300391 no 1081 0.315118417853612 1466 7350313 SGTC_414 piperonyl butoxide 100 µM 0.48114681639311 0.315999568703685 no 1082 0.31520607827509 1464 5794 A potent inhibitor of cytochrome P450. SGTC_2452 5863136 48.41 µM 0.480924483605177 0.3160788228273 no 1083 0.315285085485641 1470 2184096 SGTC_1412 3909-8563 178 µM 0.478335977718313 0.317002158961893 no 1084 0.316205546625399 1618 23767530 SGTC_1634 st006576 41 µM 0.47799649835265 0.317123338093059 no 1085 0.316326348663136 1640 3915356 SGTC_1491 4138-0063 26.5 µM 0.477333536223557 0.317360042816804 no 1086 0.316562316942453 1500 23883227 SGTC_1337 1486-1011 40.3 µM 0.47727195193352 0.317382034733143 no 1087 0.316584240446777 1493 X1337 SGTC_14 0354-0009 295 µM 0.476409474031503 0.317690095630226 no 1088 0.316891343213867 1553 1713507 SGTC_1825 st052143 62.6 µM 0.475967738226391 0.317847924265871 no 1089 0.317048681101542 1571 674173 SGTC_1318 1280-3875 124 µM 0.473693172998751 0.318661131526502 no 1090 0.317859361200268 1522 373245 SGTC_237 nikkomycin 200 µM 0.473651335756063 0.318676097462552 no 1091 0.31787428064952 1596 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine. SGTC_1568 digitonin 820 nM 0.470468158930591 0.319815643046031 no 1092 0.319010288960183 1683 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1 SGTC_922 1866-0035 480 µM 0.469878380429629 0.320026965154802 no 1093 0.319220955614753 1575 3156169 SGTC_1168 k815-0004 80.5 µM 0.469611952340744 0.320122447515375 no 1094 0.319316141872091 1496 642433 SGTC_469 w7 172 µM 0.469321548485177 0.320226535869401 no 1095 0.319419907472043 1553 45115570 A P450 inhibitor. SGTC_2089 5281248 129.67 µM 0.468905536409999 0.320375670151031 no 1096 0.319568579390702 1506 2737878 SGTC_657 3534-0529 86.7 µM 0.467892015604502 0.320739124034223 no 1097 0.319930906789895 1620 1049549 SGTC_1060 3448-7350 82 µM 0.467769630844846 0.320783023490565 no 1098 0.319974670217239 1640 570178 SGTC_860 0443-0016 25.1 µM 0.467394701239092 0.320917526469453 no 1099 0.32010875646214 1542 5337942 SGTC_2557 derrustone 83.84 µM 0.467055042498825 0.321039396603108 no 1100 0.320230249059161 1475 629853 An antioxidant. SGTC_3224 9130643 49.47 µM 0.466378391032417 0.321282237753761 no 1101 0.320472338082778 1584 17644395 SGTC_1011 4112-3381 17.4 µM 0.466356573922957 0.321290068894587 no 1102 0.320480144972582 1562 2877139 SGTC_569 4130-2812 160 µM 0.464022579814839 0.322128302565746 no 1103 0.321315784143512 1539 743552 SGTC_1077 5-fluorocytosine 377 nM 0.463512760679805 0.322311520324569 no 1104 0.321498435148948 1539 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_2243 6634756 200 µM 0.460358600043018 0.323446014589648 no 1105 0.32262942279348 1634 885676 SGTC_2041 5107442 45.335 µM 0.46016110779878 0.323517103736619 no 1106 0.322700292368262 1620 793005 SGTC_2107 5363541 170.161 µM 0.459718377124602 0.323676492113102 no 1107 0.322859188511752 1532 244052 SGTC_2099 5377090 177.372 µM 0.457443884796673 0.324495846209778 no 1108 0.323676013715982 1510 2243829 SGTC_486 niguldipine 82 µM 0.456798782912425 0.324728390108085 no 1109 0.32390784033502 1558 1236 A calcium channel blocker. SGTC_1679 SEC14.276 6.7 µM 0.455365484754446 0.32524530449627 no 1110 0.324423161029386 1673 1005053 YMR079W SEC14 SGTC_1225 1216-0074 20.6 µM 0.455297915111775 0.325269681583296 no 1111 0.324447462984329 1510 4241466 SGTC_407 eburnamonine 100 µM 0.44963906888607 0.327313867231524 no 1112 0.326485356251248 1513 3195 SGTC_369 0957-0393 4.5 µM 0.448569990811372 0.327700642665008 no 1113 0.326870942898267 1503 6997992 SGTC_1594 piperine 70.1 µM 0.448406259062784 0.327759894546851 no 1114 0.326930012714842 1514 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_1924 st058459 75.1 µM 0.448379189259462 0.327769691090355 no 1115 0.326939779157463 1547 688683 SGTC_947 3447-0010 211 µM 0.44740537223008 0.32812219360568 no 1116 0.327291198816394 1529 748350 SGTC_364 0083-0097 67.7 µM 0.444369951689754 0.329221937230803 no 1117 0.328387567184254 1582 5207356 SGTC_2651 TUB2.036 5 µM 0.444086584285158 0.329324677888366 no 1118 0.328489992754633 1628 15992207 YFL037W TUB2 SGTC_2170 morpholine 200 µM 0.443784241084838 0.329434312821649 no 1119 0.328599291502092 1631 121171 Reacts with secondary amines. SGTC_800 3448-7362 155 µM 0.443224915431174 0.329637172740735 no 1120 0.328801529491456 1613 15991913 SGTC_2909 7941780 10.49 µM 0.441546599094683 0.330246176308711 no 1121 0.329408666926619 1659 1243215 SGTC_1035 k081-0041 55.2 µM 0.441353064965502 0.330316432187453 no 1122 0.329478707616946 1613 731709 SGTC_3066 9117245 49.47 µM 0.43879592484336 0.331245274435507 no 1123 0.330404706695711 1663 17176980 SGTC_2997 9067075 71.4286 µM 0.438516830073425 0.33134671436739 no 1124 0.330505836325459 1614 27209819 SGTC_596 1155-0152 116 µM 0.436476860703832 0.33208853810244 no 1125 0.331245392064707 1555 280313 SGTC_1996 st072960 66.8 µM 0.436052191487338 0.332243049658295 no 1126 0.331399431500174 1620 1719405 SGTC_1946 st076057 65.1 µM 0.435509834257251 0.332440422264146 no 1127 0.331596201157349 1515 953009 SGTC_2227 7312221 64.1025 µM 0.43413737489648 0.332940090003803 no 1128 0.332094343160321 1606 887188 YOR168W | YOR169C GLN4 | YOR169C SGTC_3191 9110352 49.47 µM 0.432598851678762 0.3335005690096 no 1129 0.332653111915495 1607 17122424 SGTC_2653 dihydrofissinolide 100 µM 0.432133990931887 0.333669989479768 no 1130 0.332822015659404 1602 6857746 SGTC_664 1222-0054 14.9 µM 0.431810539902839 0.333787892593907 no 1131 0.332939559240547 1582 6813991 SGTC_2280 7785178 200 µM 0.430525156590282 0.334256597647863 no 1132 0.333406835574701 1591 2954328 SGTC_1975 st070967 30.8 µM 0.429453748413239 0.334647475942587 no 1133 0.333796523052423 1682 261391 SGTC_2403 6032726 181.2 µM 0.428525693504186 0.334986200056365 no 1134 0.334134215731184 1561 2881040 SGTC_122 0236-0016 402.397 µM 0.428492265084055 0.334998403362813 no 1135 0.334146381886404 1614 6808838 SGTC_360 0957-0399 1.01 µM 0.428471012052348 0.335006162038992 no 1136 0.334154116942709 1690 6752301 YPR165W RHO1 SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM 0.427778187290135 0.335259124638577 no 1137 0.334406309575889 1544 2374 Ca(2+)-ATPase inhibitor. SGTC_1543 azetidyl-2-carboxylic acid 198 µM 0.427246257434247 0.335453392371798 no 1138 0.334599986172033 1564 16486 A toxic proline analog. SGTC_1459 k035-0031 35.7 µM 0.426595816622177 0.335691001650903 no 1139 0.334836872636129 1480 3877128 YMR208W ERG12 SGTC_301 4119-0100 24.5 µM 0.426327409078978 0.33578907142553 no 1140 0.334934644145536 1610 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1 SGTC_3047 9092122 49.47 µM 0.423797219220917 0.336714091840822 no 1141 0.335856853150527 1554 17173831 SGTC_2520 obtusaquinone 4.71 µM 0.423563458854794 0.336799603038996 no 1142 0.33594210462947 1678 5967872 SGTC_2133 5320837 200 µM 0.423048470691947 0.336988019121635 no 1143 0.336129948549134 1646 2841355 SGTC_2219 9098279 200 µM 0.42221442252905 0.337293254813508 no 1144 0.33643425763756 1671 902349 SGTC_820 1582-0060 59.9 µM 0.422156948575661 0.337314292440621 no 1145 0.33645523141472 1566 3848840 SGTC_1715 st032160 10.2275 µM 0.422054554012102 0.337351773959682 no 1146 0.336492599180482 1663 5289825 SGTC_2376 9072922 81.32 µM 0.421791825267126 0.337447953172052 no 1147 0.336588486523051 1617 17087968 SGTC_2883 9059145 45.46 µM 0.419313450131136 0.338355753672299 no 1148 0.337493534027043 1565 16476510 SGTC_3304 9125678 46.087 µM 0.418062969508742 0.338814147714015 no 1149 0.33795053922223 1579 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2 SGTC_3046 9092212 49.47 µM 0.417838958444599 0.338896289652042 no 1150 0.338032432376839 1620 25236637 SGTC_1554 st069299 38.7 µM 0.417113637298314 0.339162308008794 no 1151 0.338297645233492 1633 24207999 SGTC_856 0433-0016 11.3 µM 0.416089500961825 0.339538056191412 no 1152 0.338672256151296 1600 3911780 SGTC_2293 7624732 200 µM 0.415826882217411 0.339634434819559 no 1153 0.338768343167072 1521 894453 SGTC_1896 st058441 89 µM 0.415537921058343 0.339740492985536 no 1154 0.338874080477609 1555 688759 SGTC_3282 9108498 15.4605 µM 0.414144407030446 0.340252136080561 no 1155 0.339384176362507 1578 16459645 SGTC_2757 clomiphene 4.22 µM 0.412503488563383 0.340854993493681 no 1156 0.339985212123833 1755 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined. SGTC_2266 7929956 200 µM 0.410559660844374 0.341569662924689 no 1157 0.340697723997442 1586 2967153 SGTC_2118 5526350 200 µM 0.410123740321832 0.34173001196471 no 1158 0.340857589242755 1658 743594 SGTC_2639 lactacystin 53 µM 0.410111507529706 0.34173451208807 no 1159 0.340862075790184 1705 3870 A proteasome inhibitor. SGTC_2001 4023502 57.655 µM 0.409282562273886 0.342039511677706 no 1160 0.341166155457105 1665 108941 YCR052W RSC6 SGTC_2457 5731572 11.68 µM 0.405702299549145 0.343358004724016 no 1161 0.342480676226492 1741 2865357 SGTC_2903 5923464 63.88 µM 0.405557355054557 0.343411423321533 no 1162 0.342533934041836 1644 2876576 SGTC_107 0358-0022 2.6945 µM 0.405006695955899 0.343614394596806 no 1163 0.342736294513067 1696 521106 YGL093W | YPR107C SPC105 | YTH1 SGTC_1954 st077032 68.9 µM 0.402366585532673 0.344588156816859 no 1164 0.343707128802459 1540 698907 SGTC_94 0334-0113 514.748 µM 0.402088486049139 0.344690789449119 no 1165 0.343809453070895 1565 6795178 SGTC_701 4424-0219 185 µM 0.401346077339815 0.344964831408723 no 1166 0.344082671880091 1725 2911779 SGTC_1749 st037932 54.2 µM 0.400886376744711 0.345134559391478 no 1167 0.344251890204732 1601 594497 SGTC_1435 4092-0789 56.7 µM 0.400126361524563 0.345415236120941 no 1168 0.344531724389451 1717 2248285 SGTC_1050 3232-1156 69.3 µM 0.399241363243479 0.345742176750498 no 1169 0.344857684022005 1592 700529 SGTC_2291 7917025 104.35 µM 0.398837909829431 0.345891260793924 no 1170 0.345006320885237 1563 2964612 SGTC_786 4544-0069 423 µM 0.398578649272384 0.345987075327908 no 1171 0.345101848072096 1695 748821 YLR208W SEC13 SGTC_866 0495-0101 262 µM 0.3985057205731 0.346014029255069 no 1172 0.345128721171705 1567 635694 SGTC_67 0335-0847 266 µM 0.396697028146312 0.346682758398714 no 1173 0.345795445975419 1849 4552207 YOR254C SEC63 SGTC_885 0865-0106 16.8 µM 0.396305743452785 0.346827491328823 no 1174 0.345939745359641 1561 2793380 SGTC_2200 6600604 21.907 µM 0.394894489607639 0.347349687880948 no 1175 0.346460378428285 1615 2904777 SGTC_2159 5658611 73.75 µM 0.394668160137681 0.347433462016783 no 1176 0.346543901849582 1720 793844 SGTC_2199 6590217 200 µM 0.393520110946936 0.347858518422369 no 1177 0.346967686637885 1683 703109 SGTC_739 1486-1183 203 µM 0.393321134400045 0.347932207425715 no 1178 0.34704115526956 1762 4346692 SGTC_1934 st074720 32.6 µM 0.393014611553949 0.348045736379531 no 1179 0.347154344753858 1565 17250992 SGTC_2878 9043973 25.97 µM 0.391966402857906 0.348434071452354 no 1180 0.34754151906633 1725 6465167 SGTC_191 3914-0123 66.505 µM 0.390563719714722 0.348953978998615 no 1181 0.34805987359971 1594 3144412 SGTC_1133 3473-0247 50 µM 0.389773962493187 0.349246829122113 no 1182 0.348351849470974 1568 711311 SGTC_481 bay k-8644 50 µM 0.387944300169141 0.349925631475892 no 1183 0.349028626821922 1596 2303 A calcium channel antagonist. SGTC_2383 9036125 200 µM 0.387783903452046 0.349985161360559 no 1184 0.34908797921332 1681 79580 SGTC_1642 st009582 77.7 µM 0.38748420949682 0.350096400116766 no 1185 0.349198886343653 1758 6739311 SGTC_170 4197-0004 226 µM 0.387008861023286 0.350272863732175 no 1186 0.349374823995747 1709 218692 SGTC_1887 st057648 70.8 µM 0.386945023777072 0.35029656449638 no 1187 0.349398454128429 1765 688672 SGTC_2513 baicalein 25.65 µM 0.38663404032548 0.350412031218979 no 1188 0.349513576779694 1551 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2 SGTC_2391 6285546 200 µM 0.384411705793157 0.351237575632595 no 1189 0.350336662920669 1613 846083 SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM 0.382338621692212 0.352008310476651 no 1190 0.351105105419247 1670 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_3252 9135871 49.47 µM 0.382178706920612 0.352067789186981 no 1191 0.351164407335407 1698 17682838 SGTC_757 1066-0008 322 µM 0.381971150562941 0.352144993109215 no 1192 0.351241381800579 1715 6842497 SGTC_1418 3966-3099 2.4 µM 0.381229759009688 0.352420815354958 no 1193 0.351516384493859 1716 740335 SGTC_2195 6536160 144.242 µM 0.377268576740062 0.353895818748952 no 1194 0.352987010956422 1605 3834386 SGTC_1408 3909-7976 48.8 µM 0.376546946443288 0.354164765275492 no 1195 0.353255160459218 1688 24152374 SGTC_1414 3917-0015 5.4 µM 0.376442037490235 0.354203870163976 no 1196 0.353294149487302 1706 6618702 SGTC_480 am 92016 50 µM 0.376333477489242 0.354244337601897 no 1197 0.353334497035078 1610 2129 K+ channel blocker. SGTC_2147 5545932 89.7195 µM 0.375623343778738 0.354509091626201 no 1198 0.353598466872144 1672 797404 SGTC_271 rotenone 740 µM 0.37463519126872 0.354877614362273 no 1199 0.353965898588796 1723 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria. SGTC_192 3455-0609 60.9 µM 0.37343464639768 0.355325529689455 no 1200 0.354412488677693 1694 3769639 SGTC_2253 7938677 135.83 µM 0.3733153404097 0.355370052893584 no 1201 0.354456880201409 1791 2301972 SGTC_1828 st055811 49 µM 0.373313160659643 0.355370866361956 no 1202 0.354457691263976 1790 5877589 SGTC_2469 5655019 90.81 µM 0.37276634184168 0.355574956353163 no 1203 0.3546611777606 1778 2788239 SGTC_518 1021-0119 62.6 µM 0.371946328941658 0.355881088578879 no 1204 0.354966405106179 1598 1097762 SGTC_3140 9094243 49.47 µM 0.370380082094425 0.356466067612536 no 1205 0.35554965621346 1705 19291112 SGTC_1608 st001473 40.5 µM 0.369993502852694 0.356610503501843 no 1206 0.355693665703672 1612 7292267 SGTC_92 0063-0024 660.874 µM 0.368120851764226 0.357310464590594 no 1207 0.356391561735934 1684 3594437 SGTC_6 0844-0013 19.835 µM 0.367572660274704 0.357515459066238 no 1208 0.35659595185119 1743 1584900 SGTC_1762 st045503 25.4615 µM 0.366069213604114 0.358077879058898 no 1209 0.357156714716974 1670 4645554 SGTC_472 calcifediol 10 µM 0.365820714852834 0.358170868940887 no 1210 0.357249430751202 1696 5283731 A vitamin D metabolite. SGTC_954 1189-0853 2.85 µM 0.364155131256048 0.358794358324493 no 1211 0.357871085034881 1677 2828194 SGTC_2812 7970281 58.44 µM 0.363855586165664 0.358906529088328 no 1212 0.357982925839339 1788 2233435 SGTC_1709 st033179 39.1045 µM 0.363690590765209 0.358968320176341 no 1213 0.358044535188637 1657 573381 SGTC_278 4092-0821 23.9 µM 0.363580440279066 0.359009573795022 no 1214 0.358085667482798 1738 877900 SGTC_2971 9092186 9.93 µM 0.363150688171947 0.359170540501036 no 1215 0.358246160870061 1556 25236400 SGTC_3289 9119912 71.43 µM 0.361950763690834 0.359620113029935 no 1216 0.358694412075477 1701 17014829 SGTC_1170 0310-0127 64.8 µM 0.361797525924654 0.359677540225324 no 1217 0.358751670555839 1739 774975 SGTC_1188 1403-0014 4.57 µM 0.36081242572093 0.360046790764651 no 1218 0.359119836640927 1680 9614867 SGTC_619 1652-1634 108 µM 0.359782221311117 0.360433087699769 no 1219 0.359504999734906 1673 5400454 SGTC_1737 st035557 69.7 µM 0.359324432001192 0.360604791240392 no 1220 0.35967619952166 1632 5716916 SGTC_1998 st075797 76.8 µM 0.359218017496692 0.360644708273396 no 1221 0.359715999463382 1799 24208315 SGTC_1902 st060212 70.5 µM 0.358188352341244 0.361031023258219 no 1222 0.360101181628078 1665 688944 SGTC_169 k015-0017 16.025 µM 0.357992389199686 0.361104561774836 no 1223 0.360174504581019 1761 1840002 SGTC_666 0272-0154 136 µM 0.357363081100901 0.361340755092987 no 1224 0.360410005715614 1711 6870312 SGTC_2002 4023503 131 µM 0.357017693493758 0.361470409212826 no 1225 0.360539279984324 1873 4736863 YCR052W RSC6 SGTC_2504 purpurogallin 52.29 µM 0.356297912195109 0.361740657078045 no 1226 0.360808736349725 1666 5281571 An antioxidant. SGTC_2197 6588183 93.1375 µM 0.356085858474157 0.361820287567079 no 1227 0.360888133682772 1715 884136 SGTC_2864 9034755 47.6 µM 0.355410006333971 0.362074123713173 no 1228 0.361141226801456 1735 4930451 SGTC_1211 1056-0033 32.3 µM 0.354924945705103 0.362256339903699 no 1229 0.361322909796206 1807 6741922 SGTC_2943 9068529 45.32 µM 0.354003640479531 0.36260252014694 no 1230 0.361668077486024 1692 3270634 SGTC_1456 k015-0012 13 µM 0.353460202409876 0.362806769587116 no 1231 0.361871729774779 1870 2989616 SGTC_2730 imipramine 71.33 µM 0.352844061462194 0.363038391389405 no 1232 0.362102674636305 1773 3696 A tricyclic antidepressant. SGTC_1290 0986-0249 10.2 µM 0.352250250721436 0.363261666161 no 1233 0.362325297101517 1748 53329 SGTC_1947 st076332 61.6 µM 0.352005555280997 0.363353685967596 no 1234 0.362417048136889 1797 24208416 SGTC_76 0433-0009 400.328 µM 0.350732869272457 0.363832417458887 no 1235 0.362894381995542 1688 2841569 SGTC_2951 9072950 58.06 µM 0.349152128503936 0.364427322339701 no 1236 0.363487551592382 1759 16488155 SGTC_3161 9100388 49.47 µM 0.347755346562138 0.364953267081774 no 1237 0.364011963599507 1767 25236368 SGTC_1278 0874-0585 172 µM 0.347428129246686 0.365076514385455 no 1238 0.364134851919841 1749 766306 SGTC_62 0180-0423 3.232 µM 0.346567798363742 0.365400626859714 no 1239 0.364458020694554 1771 30102 YGL099W LSG1 SGTC_713 1488-1073 324 µM 0.346467624504817 0.365438371613526 no 1240 0.364495655581703 1787 3312542 SGTC_1392 3455-1037 33.9 µM 0.34477324537789 0.366076998051674 no 1241 0.365132424150235 1790 981132 SGTC_2471 5466956 24.79 µM 0.344624912083072 0.366132923874036 no 1242 0.365188187368011 1755 724419 SGTC_2698 st077697 67.5 µM 0.344157306903147 0.366309242781534 no 1243 0.365363993725508 1640 3154499 SGTC_617 3770-0098 35 µM 0.343897610172446 0.366407178278835 no 1244 0.365461644593691 1725 5962639 SGTC_1529 apigenin 74 µM 0.343728135366728 0.366471094439248 no 1245 0.365525375019894 1821 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_2472 5377652 49.4 µM 0.343598735687968 0.366519899057772 no 1246 0.365574037830085 1689 1610903 SGTC_1070 indatraline 8.81 µM 0.343524908670863 0.366547744757121 no 1247 0.365601802625156 1680 10314472 A monamine transport inhibitor. YGL099W LSG1 SGTC_529 4076-0302 30.3 µM 0.343432821397061 0.366582478751931 no 1248 0.365636435707306 1687 5816522 SGTC_744 1594-0068 283 µM 0.343296162701475 0.366634026459725 no 1249 0.365687833664238 1703 668392 SGTC_2161 5662504 8.5105 µM 0.342723012385372 0.366850245151228 no 1250 0.365903424359399 1685 2859334 SGTC_84 0443-0269 128.823 µM 0.342204277328628 0.367045972327389 no 1251 0.366098583249485 1757 6150058 SGTC_2202 7226349 200 µM 0.340051170124061 0.367858743632244 no 1252 0.366908996678301 1696 844334 SGTC_382 3229-0966 23.2 µM 0.339010200197219 0.368251909427466 no 1253 0.36730102303078 1806 5722370 SGTC_3272 9137413 49.47 µM 0.337596853942712 0.368785939544796 no 1254 0.367833506661528 1621 17614870 SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM 0.335857004402024 0.369443686269347 no 1255 0.368489350533225 1697 115019 SGTC_646 4092-0839 27.3 µM 0.334631113216331 0.369907361754551 no 1256 0.368951685876367 1811 877796 SGTC_1356 1502-0781 85.8 µM 0.333035115261906 0.370511308138371 no 1257 0.369553888272334 1736 567702 SGTC_396 dithiazanine 1.25 µM 0.331430313094895 0.371118908100423 no 1258 0.370159735497551 1705 10578 An antihelmenthic. SGTC_880 0833-0487 87.2 µM 0.331316071667493 0.371162173733232 no 1259 0.370202876391521 1687 76075 SGTC_674 0498-0004 451 µM 0.330717954854159 0.371388719727485 no 1260 0.370428769382724 1700 4231473 SGTC_867 0518-0118 155 µM 0.330545582296679 0.371454016775069 no 1261 0.370493878262936 1773 6848158 SGTC_24 0417-1663 219 µM 0.329831568655235 0.371724534145765 no 1262 0.370763616303528 1733 4329390 SGTC_127 0180-0333 59.125 µM 0.329134809219132 0.371988575516363 no 1263 0.371026897348101 1776 771601 SGTC_760 0568-0725 82.9 µM 0.327964438250538 0.372432230416619 no 1264 0.371469275486453 1865 3916171 SGTC_2769 toremifene 3.73 µM 0.326120407483474 0.37313159431038 no 1265 0.372166628707672 1765 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_2127 5253358 187.912 µM 0.324065435090905 0.373911452241333 no 1266 0.372944247405384 1695 20612 SGTC_1111 tnp00062 510.699 nM 0.323964214557477 0.373949878602945 no 1267 0.37298256351019 1857 676306 SGTC_3313 9133968 57.047 µM 0.323139600305002 0.374262973639338 no 1268 0.373294760456632 1766 1494643 SGTC_2218 6965428 192.983 µM 0.321345875063543 0.37494431339795 no 1269 0.373974147532308 1817 675684 SGTC_620 0109-0052 432 µM 0.320393771274664 0.375306125205462 no 1270 0.374334923350064 1842 493037 SGTC_2562 3',7'-dimethoxyflavone 64.92 µM 0.319560244328584 0.375622966363526 no 1271 0.374650857823187 1917 688664 SGTC_2334 9017922 200 µM 0.318953947466359 0.375853485298913 no 1272 0.374880717413172 1870 3163164 SGTC_2179 6298986 200 µM 0.318921559115347 0.375865800857584 no 1273 0.374892997753581 1887 738374 SGTC_1865 st057639 52.2 µM 0.317486429908091 0.3764116305498 no 1274 0.375437267326541 1775 688818 SGTC_3159 9100096 49.47 µM 0.317075031616412 0.37656814531108 no 1275 0.375593335005734 1706 25236875 SGTC_1178 0988-0033 191 µM 0.31485541466123 0.377412938818192 no 1276 0.376435717507029 1784 5392207 SGTC_150 3970-0969 77.2 µM 0.314183879894047 0.377668642986704 no 1277 0.376690692617814 1777 6615640 SGTC_3149 9097855 49.47 µM 0.313781244062555 0.377821982676527 no 1278 0.376843595267996 1890 25236625 YMR079W SEC14 SGTC_105 0111-0055 734.78 µM 0.312001269877757 0.378500097827353 no 1279 0.377519779126177 1780 5179370 SGTC_268 camptothecin 39.6153 µM 0.311203135391676 0.37880428407736 no 1280 0.377823099804046 1760 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_159 3970-0959 50 µM 0.311077428863638 0.378852200393081 no 1281 0.377870879815248 1837 6615653 SGTC_2598 perillyl alcohol 100 µM 0.310181346629123 0.379193819369326 no 1282 0.378211527348759 1821 10819 An apoptosis inducer. SGTC_1368 1852-0141 284 µM 0.309404650070563 0.379490000560784 no 1283 0.378506866788405 1766 2838987 SGTC_332 4112-0506 40.9 µM 0.308392160042969 0.379876204117335 no 1284 0.378891973421677 1771 2790355 SGTC_970 1315-0089 19.5 µM 0.307706517664459 0.380137803191341 no 1285 0.37915282991684 1700 6811083 YLR033W RSC58 SGTC_2783 7738165 71.43 µM 0.306941285135519 0.380429833743951 no 1286 0.379444031921827 1661 17201110 SGTC_2236 dapsone 200 µM 0.306761895309741 0.380498302946867 no 1287 0.379512306927597 1863 2955 A bacterial DFR inhibitor. An anti-cancer agent. SGTC_2014 4013930 200 µM 0.306286978483027 0.380679586461821 no 1288 0.379693076389832 1893 64556 SGTC_2896 9052656 71.43 µM 0.302968220447713 0.381947139888653 no 1289 0.380957040233312 1797 6469436 SGTC_1014 4130-3005 69.3 µM 0.302489846919321 0.382129952757416 no 1290 0.381139336078744 1738 743608 SGTC_911 3456-4043 236 µM 0.301257106815596 0.38260117167241 no 1291 0.381609223110805 1842 914281 SGTC_2503 beta-caryophyllene alcohol 24.72 µM 0.299892548985875 0.383122981072053 no 1292 0.382129558979031 1769 61125 An anti-inflammatory. SGTC_2283 7944793 200 µM 0.299289940864468 0.383353487102089 no 1293 0.382359414536328 1713 2970533 SGTC_3274 9138298 49.47 µM 0.299099814101359 0.383426221820944 no 1294 0.38243194406 1800 17015756 SGTC_1469 k284-2957 126 µM 0.294952738719779 0.385013741194878 no 1295 0.384014991687742 1833 23884841 SGTC_2683 piperine 63.03 µM 0.294780739556116 0.385079625110183 no 1296 0.384080690305273 1804 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_1559 coumarin 343 70.1 µM 0.293659387629897 0.385509237832372 no 1297 0.38450909530507 1851 108770 A hepatotoxic, DNA x-linker. SGTC_3014 9081533 49.47 µM 0.292336774821411 0.386016138266139 no 1298 0.385014571993676 1909 21367265 SGTC_2972 9093619 59.92 µM 0.292297719538479 0.386031109434403 no 1299 0.385029501132571 1712 25236256 SGTC_1113 artemisinin 1.17947 µM 0.292023810499106 0.386136112502621 no 1300 0.385134209453194 1935 2240 An anti-malaria and mitochondrial poison. SGTC_98 0074-0023 107.663 µM 0.291153652928355 0.386469742831504 no 1301 0.385466903654859 1739 3563821 SGTC_1648 st011736 69.8 µM 0.290914098298828 0.386561606103267 no 1302 0.385558509272275 1876 2855514 SGTC_306 1672-3436 11.6 µM 0.290543690637163 0.386703660787591 no 1303 0.38570016561517 1846 6797378 SGTC_1420 4'-methoxyflavone 42 µM 0.28969029233374 0.387031004498903 no 1304 0.38602659181448 1922 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13 SGTC_2712 st079126 47.7 µM 0.288823657935442 0.387363507513611 no 1305 0.386358163436683 1788 3152970 SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM 0.288149681384114 0.387622150325482 no 1306 0.386616082155039 1760 4174840 SGTC_140 0062-0056 502.533 µM 0.287958086073652 0.387695685361008 no 1307 0.38668941138749 1736 3758964 SGTC_2390 9097792 176.6 µM 0.287804279752524 0.387754719748486 no 1308 0.386748280575737 1727 4497149 SGTC_1751 st044839 27.194 µM 0.28773258335376 0.387782239354585 no 1309 0.386775723178504 1888 5291326 SGTC_991 3996-0057 64.7 µM 0.287550191805685 0.387852250203146 no 1310 0.386845538146003 1799 715343 SGTC_1220 1838-0075 193 µM 0.287094012036358 0.388027370397355 no 1311 0.387020168491172 1838 5529645 SGTC_1822 st052468 42 µM 0.286583317317906 0.388223445033854 no 1312 0.38721569485797 1799 2873678 SGTC_2059 5238311 157 µM 0.285141812397 0.388777045784683 no 1313 0.387767748718592 1773 703021 SGTC_614 0462-0418 107 µM 0.28426359655444 0.389114429796862 no 1314 0.388104190802164 1831 5188303 SGTC_1244 0416-0015 52.5 µM 0.282834788877163 0.389663513167037 no 1315 0.388651742509344 1811 96201 SGTC_36 0335-0881 14.2 µM 0.282333340258411 0.389856269549671 no 1316 0.388843961582462 1820 23828853 SGTC_91 0417-1751 58.384 µM 0.282188126007471 0.389912094833389 no 1317 0.388899631290062 1867 6795624 SGTC_564 3555-0129 330 µM 0.281954281943944 0.390001997195786 no 1318 0.388989283144099 1923 563260 SGTC_3163 9099914 49.47 µM 0.281416683321989 0.39020870161925 no 1319 0.389195411760624 1887 16268368 SGTC_3197 9113331 49.47 µM 0.280913835194726 0.390402072723069 no 1320 0.389388244407136 1925 16610459 YLR208W | YDL195W SEC13 | SEC31 SGTC_2459 5811157 9.22 µM 0.280709074281614 0.39048082165233 no 1321 0.389466774111255 1896 2870684 YBR192W RIM2 SGTC_2139 5578692 56.4705 µM 0.280159220795266 0.390692311839911 no 1322 0.389677675707021 1940 650991 YMR113W FOL3 SGTC_715 0868-0130 184 µM 0.279980531849906 0.390761047947866 no 1323 0.38974622056943 1964 2876258 SGTC_1440 4100-1550 40 µM 0.279727628395384 0.390858337914885 no 1324 0.389843239888513 1895 742806 SGTC_1228 0124-0032 52.5 µM 0.279205042189496 0.391059394349472 no 1325 0.390043737171927 1888 X1228 SGTC_2737 bleomycin 30.5 nM 0.279160670903588 0.391076466812744 no 1326 0.390060762165584 1826 16211318 Bleomycin acts by induction of DNA strand breaks. SGTC_2621 lithochol-11-enic acid 100 µM 0.278917762809729 0.391169932765829 no 1327 0.39015396826645 1954 6708711 SGTC_1478 0453-0656 35.7 µM 0.27822041311086 0.391438293247859 no 1328 0.390421582919677 1872 5258496 SGTC_2622 2-methoxyxanthone 59.94 µM 0.278106674316377 0.391482068155161 no 1329 0.390465236204395 1950 71034 A hepatoprotective. SGTC_2996 9066192 71.4286 µM 0.277004382591233 0.391906380787816 no 1330 0.39088837047887 1718 6472854 SGTC_2416 tofa 880 nM 0.276371862920922 0.392149918976851 no 1331 0.39113123277793 1687 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_1246 0422-0085 105 µM 0.274674614864336 0.392803616650161 no 1332 0.391783117836885 1949 264295 SGTC_174 3553-0389 74.3 µM 0.274592091795945 0.392835408261125 no 1333 0.391814821353161 1870 738071 SGTC_1740 st038286 13.222 µM 0.268890098221348 0.395033793753593 no 1334 0.394007128463596 1864 716786 SGTC_507 nimesulide 162 µM 0.268033054783791 0.39536451506413 no 1335 0.394336937639469 1960 4495 A COX2 inhibitor. SGTC_322 k048-0136 19.3 µM 0.267913200888681 0.395410771051715 no 1336 0.39438306610015 1875 6823282 SGTC_2120 5538279 151.968 µM 0.267490063669276 0.395574086910888 no 1337 0.394545931794497 1846 2058197 SGTC_2429 5902844 64.44 µM 0.266765914685072 0.395853625097309 no 1338 0.394824699800358 1965 1927790 YGL093W | YPR107C SPC105 | YTH1 SGTC_831 k061-1017 217 µM 0.266381746658539 0.396001944562352 no 1339 0.39497261079177 1931 1240153 SGTC_778 3456-2434 196 µM 0.264021808398934 0.396913398336935 no 1340 0.395881557073252 1978 5539063 SGTC_844 0330-0132 15.3 µM 0.263637202405144 0.397061994130299 no 1341 0.396029744500757 1914 2828079 SGTC_794 k038-0031 316 µM 0.262801245330775 0.397385024765917 no 1342 0.39635188781606 1801 6624242 SGTC_1479 0549-0158 134 µM 0.262685192855865 0.397429875347022 no 1343 0.396396615244515 1828 5440202 SGTC_1145 3546-0597 10.2 µM 0.26235617123189 0.3975570390842 no 1344 0.396523429870638 1849 875334 SGTC_1289 0976-0073 69.1 µM 0.260271314487347 0.398363068979224 no 1345 0.397327249004643 1903 3391136 SGTC_128 0906-2981 13.371 µM 0.25909579997828 0.39881772806758 no 1346 0.397780662657119 1961 6740226 SGTC_1452 4194-0072 190 µM 0.258831511271261 0.398919967142984 no 1347 0.397882621830218 1979 1343545 SGTC_2326 6164455 177.58 µM 0.256889515588075 0.399671433028849 no 1348 0.398632032200135 1830 2888790 SGTC_2188 6126565 140.678 µM 0.255626900642874 0.400160208432259 no 1349 0.399119472330227 1941 874518 SGTC_454 lyso-paf C-16 6.67 µM 0.254711885299019 0.400514521113669 no 1350 0.399472817910505 1763 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_1330 1469-0054 61.8 µM 0.254405740685457 0.400633084872739 no 1351 0.39959105820551 1988 7102664 SGTC_1189 1431-2119 7.28 µM 0.253322486081372 0.401052681415503 no 1352 0.400009510644831 1864 3107275 SGTC_352 k048-0007 5.11 µM 0.253059043102356 0.401154742811864 no 1353 0.4001112939026 1922 6811911 SGTC_3049 9092223 49.47 µM 0.25280441815231 0.40125339439446 no 1354 0.40020967669477 1883 8623917 SGTC_3318 9139014 38.6185 µM 0.250173819476422 0.402272957761426 no 1355 0.401226465328093 1857 16643984 SGTC_2630 antimycin a 100 µM 0.249430844751669 0.402561039532765 no 1356 0.401513764151024 1837 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain. SGTC_54 0159-0055 9 µM 0.249084220983213 0.402695457896611 no 1357 0.401647817353456 1995 3319099 SGTC_2420 aureobasidin a 50 nM 0.248335787775101 0.402985734470439 no 1358 0.401937305710088 1985 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1 SGTC_2193 5925765 200 µM 0.247455930748172 0.403327051578588 no 1359 0.402277696616824 1952 877370 SGTC_1809 st050081 57.6 µM 0.247334947365077 0.403373989627041 no 1360 0.402324507345458 1942 5036894 SGTC_1256 0570-0116 285 µM 0.244879862341399 0.404326791342693 no 1361 0.403274727287743 1796 410638 SGTC_1537 2',6'-dihydroxyflavanone 78 µM 0.244279421723421 0.404559904865337 no 1362 0.40350720993831 1875 5106787 A p450 inhibitor. SGTC_2203 7227154 166.4 µM 0.243974226087227 0.404678406228103 no 1363 0.403625390721287 1920 896304 SGTC_924 2046-0044 21.3 µM 0.240835777709946 0.40589750836244 no 1364 0.404841199501975 1855 3623589 SGTC_180 1486-1293 102.781 µM 0.240784920722347 0.405917270853266 no 1365 0.404860908675401 2038 4140536 SGTC_901 1112-0062 60.1 µM 0.239573048795054 0.406388262363515 no 1366 0.405330630157262 1879 1908457 SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM 0.239485768414511 0.406422188940391 no 1367 0.405364465300369 1846 6708784 An antioxidant flavonoid SGTC_2718 lomofungin 53.02 µM 0.236951428114304 0.407407612494434 no 1368 0.406347235982889 1985 5351222 A RNA synthesis inhibitor. SGTC_743 1275-0778 158 µM 0.236144337948376 0.407721555471246 no 1369 0.406660334966618 1976 2849257 YMR203W TOM40 SGTC_1082 camptothecin 424.86 nM 0.235538913302845 0.407957093248367 no 1370 0.406895239906565 1648 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_385 1494-0393 12.4 µM 0.234992934353487 0.408169532471763 no 1371 0.40710710862884 1921 3090647 SGTC_2654 protoveratrine a 100 µM 0.234557242142614 0.408339078734516 no 1372 0.407276199766216 1927 5702278 A heart drug and vasodilator. SGTC_1790 st045711 43.5 µM 0.233568020141723 0.408724090509051 no 1373 0.407660178644691 2012 585119 SGTC_148 3253-0744 288.01 µM 0.231004502806404 0.40972223759671 no 1374 0.408655651949898 1971 6893655 SGTC_1193 1488-0126 41.5 µM 0.230703581302316 0.409839444783962 no 1375 0.408772545549489 1866 1384710 SGTC_2576 guaiol 23.12 µM 0.230447892265146 0.409939040518399 no 1376 0.408871874878653 2042 227829 SGTC_2239 6685329 187.64 µM 0.230298067667976 0.409997402743887 no 1377 0.408930081019886 1853 805680 SGTC_1652 st011932 78 µM 0.22961950077238 0.410261754609157 no 1378 0.409193726150106 1982 1551076 SGTC_545 4218-0007 221 µM 0.229579912329145 0.410277178488522 no 1379 0.409209108806895 1904 2840508 SGTC_926 2268-1401 59.4 µM 0.22443608133457 0.412282416026529 no 1380 0.411208998923529 2026 2931578 SGTC_187 1488-2104 32.728 µM 0.224343050067463 0.412318703987997 no 1381 0.41124519033252 1995 2852859 SGTC_273 hydroxyurea 18.1 mM 0.218577038797725 0.414569256911299 no 1382 0.413489770346555 1913 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12 SGTC_305 1682-2595 20.8 µM 0.21808266839384 0.414762348142167 no 1383 0.413682350516885 1946 226033 SGTC_1154 4088-0362 150 µM 0.217689654813829 0.414915866114388 no 1384 0.413835462326602 1916 6618304 SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM 0.21755607721462 0.414968046818783 no 1385 0.413887505008448 1903 688788 SGTC_1395 3486-0190 4.35 µM 0.217184774109337 0.415113100405588 no 1386 0.414032175000943 2040 6748079 SGTC_983 1491-0821 12.2 µM 0.216774575538419 0.41527336238122 no 1387 0.414192013309419 2019 46495113 SGTC_2093 5331342 194.4 µM 0.21674141210147 0.415286319741646 no 1388 0.414204936422568 2032 33839 SGTC_2963 9082507 9 µM 0.216121348948622 0.415528602949841 no 1389 0.414446579442435 1955 16459611 SGTC_1984 st072354 53.1 µM 0.215326432635029 0.415839255176208 no 1390 0.41475641134058 1944 5762938 SGTC_902 1120-0002 2.07 µM 0.215029960166483 0.415955129695375 no 1391 0.414871980021647 1888 3280475 SGTC_1956 st077085 54 µM 0.214193847222865 0.416281958846672 no 1392 0.415197946975731 1889 24208685 SGTC_1997 st073024 93.8 µM 0.213418092057896 0.416585246458813 no 1393 0.415500435066664 2041 686268 SGTC_160 3453-0671 289.699 µM 0.212699471272197 0.41686624124956 no 1394 0.415780689595992 1932 5322268 SGTC_2005 4024620 188 µM 0.212586367767707 0.416910470805795 no 1395 0.415824802675637 1953 236743 SGTC_1476 4112-3294 3.34 µM 0.211842258302616 0.41720148384165 no 1396 0.41611504963423 2005 704369 SGTC_686 1319-0111 510 µM 0.21015999495085 0.417859565534591 no 1397 0.416771400836695 2021 4562600 SGTC_3177 9107506 49.47 µM 0.210045504810006 0.417904361117471 no 1398 0.416816078719915 2040 8897194 SGTC_2881 9058953 51.95 µM 0.208904461283748 0.418350865620088 no 1399 0.417261410700255 1985 17122249 SGTC_807 1315-0151 48 µM 0.208645559075941 0.418452191937776 no 1400 0.41736247110209 2073 4011080 SGTC_1078 idebenone 36.1 µM 0.203485357558618 0.420472855420461 no 1401 0.419377844626915 1979 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen. SGTC_1349 flufenamic acid 69 µM 0.203419745334717 0.420498561876132 no 1402 0.419403483944459 1934 3371 A non-steroidal anti-inflammatory. SGTC_314 1671-0008 2.74 µM 0.202826242220624 0.420731108046964 no 1403 0.419635422951973 1972 3913060 SGTC_1482 3346-2049 8.48 µM 0.202624230617195 0.420810266473424 no 1404 0.419714374775912 2025 3826804 SGTC_1702 st027038 51 µM 0.202612107332207 0.420815017095305 no 1405 0.419719112999941 1976 5521182 SGTC_3028 9087778 49.47 µM 0.20143595762608 0.421275957010467 no 1406 0.420178850639572 1921 17217395 SGTC_1240 0356-0016 42.1 µM 0.200929374602243 0.421474523132776 no 1407 0.420376899238751 1958 4305613 SGTC_1990 st072050 59.8 µM 0.199075251463669 0.422201456556392 no 1408 0.42110194011071 1886 17233948 SGTC_1847 st056231 15 µM 0.196296140666084 0.423291539345603 no 1409 0.422189190966816 2010 5393180 SGTC_2220 6782180 200 µM 0.195762243107489 0.423501023688448 no 1410 0.422398131925152 2047 833803 SGTC_200 k038-0079 37.545 µM 0.194123928868431 0.42414398059198 no 1411 0.423039422741044 2003 3436683 SGTC_2553 4-methylesculetin 85.09 µM 0.193744495389879 0.424292918235895 no 1412 0.42318797480801 1893 5319502 SGTC_520 3584-0023 682 µM 0.193482290736897 0.424395846793669 no 1413 0.423290636979397 1901 1340790 SGTC_2055 5235184 200 µM 0.193053545922352 0.424564161874673 no 1414 0.423458516590063 1960 2836034 SGTC_471 1-acyl-paf 4 µM 0.192074382996958 0.424948609632664 no 1415 0.423841970348971 1905 16759367 SGTC_1614 st002383 48.6 µM 0.190578727152637 0.425535985180329 no 1416 0.424427828989753 2107 1947235 SGTC_2822 7994718 71.43 µM 0.190549198723452 0.425547583284494 no 1417 0.424439397163157 2043 1018011 SGTC_952 1185-0122 232 µM 0.189578888792358 0.425928735026645 no 1418 0.424819565746863 2014 678600 SGTC_1793 st048256 72.231 µM 0.189490233819985 0.425963563435182 no 1419 0.424854304362557 2058 672022 SGTC_2841 9004761 38.96 µM 0.186725322578843 0.427050056792066 no 1420 0.425938000367055 1834 2991039 SGTC_1769 st044406 64.4 µM 0.186264055458601 0.427231369399844 no 1421 0.426118846872533 1938 670903 SGTC_3247 9135149 49.47 µM 0.18526607450303 0.427623703398992 no 1422 0.426510172997127 2050 8934436 YOR116C RPO31 SGTC_2649 anisomycin 9.56 µM 0.184392134157603 0.427967332394626 no 1423 0.426852920028026 1993 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_1651 st011928 86.1 µM 0.183360151254898 0.428373173270302 no 1424 0.427257720216977 2023 720198 SGTC_583 1488-1091 88.9 µM 0.183163034688936 0.428450700588425 no 1425 0.427335048851343 2125 4303273 SGTC_3317 9138495 8.753 µM 0.182905253189494 0.428552092013766 no 1426 0.427436180491886 2111 17020139 SGTC_2610 ononetin 44.17 µM 0.18189376027703 0.428949981064407 no 1427 0.427833050695894 1945 259632 SGTC_3091 9116372 49.47 µM 0.181151112532233 0.429242160997429 no 1428 0.428124483097624 2007 17169793 SGTC_2722 naftopidil 47.16 µM 0.180017996784101 0.429688037428668 no 1429 0.428569219806187 2067 4418 An a1-adrenergic receptor antagonist or alpha blocker.  SGTC_261 5-fluorouridine 15.376 µM 0.179700854020773 0.429812847904963 no 1430 0.428693711473728 2073 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_2152 5568786 200 µM 0.179349883166676 0.429950979490045 no 1431 0.428831490337866 2040 5399883 SGTC_222 nsc-310342 10.666 µM 0.178085903782712 0.430448514732458 no 1432 0.42932775611492 2109 432556 SGTC_1655 st012546 55.1 µM 0.177326132185687 0.430747633835821 no 1433 0.429626112766111 2023 720985 YLR208W SEC13 SGTC_1519 esterone 74 µM 0.176687037266114 0.430999273779701 no 1434 0.429877111720181 1877 698 A steroid. SGTC_822 1487-0950 154 µM 0.176273114559114 0.431162268415853 no 1435 0.430039691382225 2109 1958375 SGTC_1755 st041960 45.185 µM 0.175034438856392 0.431650104522326 no 1436 0.430526286494877 1986 2257073 SGTC_3238 9133470 49.47 µM 0.174728834293663 0.431770478916636 no 1437 0.430646354904098 2116 3534688 SGTC_679 0422-0091 41.4 µM 0.174466141937186 0.431873955712339 no 1438 0.430749568741027 1951 627384 YHR062C RPP1 SGTC_2803 7707263 71.43 µM 0.170792988737397 0.433321329068511 no 1439 0.432193271124572 1967 2199229 SGTC_557 1315-0110 16.2 µM 0.170334996246029 0.433501860072038 no 1440 0.432373345184467 2041 6833801 SGTC_551 k048-0028 34.9 µM 0.170334476524614 0.433502064943173 no 1441 0.432373549537169 2070 6836383 SGTC_2591 skatole 100 µM 0.170049847245793 0.433614266819216 no 1442 0.432485467523146 2001 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite. SGTC_1553 gossypol 38.6 µM 0.169922291398972 0.433664551525202 no 1443 0.432535625026289 2085 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_746 1095-0025 46.6 µM 0.168629854271324 0.434174112860088 no 1444 0.433043898260695 2070 6749286 SGTC_47 0149-0135 24.25 µM 0.166792640119325 0.434898648209115 no 1445 0.433766604950075 1992 5239155 SGTC_812 4251-0442 148 µM 0.165799776455474 0.435290291351396 no 1446 0.434157261025261 2119 5723007 SGTC_2849 9019321 12.99 µM 0.165588623862239 0.435373590407405 no 1447 0.434240350267991 2024 16489627 SGTC_3228 9131799 49.47 µM 0.164869918712616 0.435657138874573 no 1448 0.434523184869396 2033 17015818 SGTC_2779 methotrexate 400 µM 0.164859818262239 0.435661124009339 no 1449 0.434527159974818 2120 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2 SGTC_3266 9136860 49.47 µM 0.163042842236664 0.436378118185347 no 1450 0.435242351366386 2053 4871271 YPR165W RHO1 SGTC_2686 alizarin 95.37 µM 0.162718150032725 0.436506266576606 no 1451 0.435370177895478 1978 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1 SGTC_335 4077-0256 27.6 µM 0.162612290038455 0.436548048472669 no 1452 0.43541185487355 2100 3121989 SGTC_828 2074-0507 139 µM 0.162391891804355 0.436635039753494 no 1453 0.435498627747875 2118 X828 SGTC_567 1080-0542 68.4 µM 0.162281467957142 0.436678625247572 no 1454 0.435542103831508 2122 5950415 SGTC_2388 9080168 200 µM 0.161557324201225 0.436964471694417 no 1455 0.435827233037154 1940 15943073 SGTC_204 PMA1.184 62.41 µM 0.161249131511584 0.437086136793401 no 1456 0.435948593016522 2125 2252213 YGL008C PMA1 SGTC_1581 himbacine 57.9 µM 0.160732825226097 0.437289972137721 no 1457 0.436151917384238 1969 5281825 An alkaloid muscarinic receptor antagonist. SGTC_3110 9122132 49.47 µM 0.160160119164907 0.437516093324938 no 1458 0.436377472043536 2094 918317 SGTC_2350 9023895 38.85 µM 0.158519244052325 0.4381640718086 no 1459 0.437023828908711 2062 2997209 SGTC_1003 4049-0218 100 µM 0.156277475282888 0.439049609765495 no 1460 0.437907155151494 2073 295161 SGTC_2296 7971656 126.45 µM 0.155860505583893 0.43921435389444 no 1461 0.438071488380368 2022 666570 SGTC_1404 3909-7820 48.3 µM 0.154799098304321 0.439633761834933 no 1462 0.438489851045433 2135 23741373 SGTC_2223 6903751 107.57 µM 0.14851745247082 0.442117283564938 no 1463 0.440967206806008 2103 5598863 SGTC_804 1595-0054 20.9 µM 0.148383369517424 0.442170319984813 no 1464 0.441020111991972 2004 761523 Stimulates phospholipase C. SGTC_2144 5628481 200 µM 0.148012138639603 0.44231716550804 no 1465 0.441166594255823 2028 2818399 SGTC_2294 7971431 200 µM 0.147538998256431 0.442504334235776 no 1466 0.441353300180924 2100 5741572 SGTC_2539 epi(13)torulosol 80 µM 0.147410684277826 0.442555095938846 no 1467 0.441403936407982 2022 6708597 SGTC_1988 st071872 53.4 µM 0.147043957970576 0.442700180043664 no 1468 0.441548661978538 2163 16414116 SGTC_2720 fluspirilene 36.88 µM 0.146657376387354 0.442853127603593 no 1469 0.441701231722553 2117 3396 An atypical antipsychotic. SGTC_961 1252-1571 372 µM 0.146630005856106 0.442863956833579 no 1470 0.441712034207695 2142 6813498 SGTC_3257 9139206 32.98 µM 0.146261163187166 0.443009894664219 no 1471 0.441857611692768 2120 4910041 SGTC_2171 5739187 198.077 µM 0.146111162102878 0.443069246932307 no 1472 0.441916817450223 2062 2262761 SGTC_3131 9127911 49.47 µM 0.14589435654248 0.443155034581013 no 1473 0.442002393373961 2080 45595681 SGTC_652 0437-0092 114 µM 0.144182340733595 0.443832554264005 no 1474 0.442678242643261 2096 3091274 SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM 0.144025902834113 0.443894471813897 no 1475 0.442740007688266 2116 16725076 SGTC_2174 5790901 200 µM 0.143161132079037 0.444236769594053 no 1476 0.443081462837548 2047 786020 SGTC_253 dyclonine 31.25 µM 0.141886961219289 0.444741193850035 no 1477 0.443584646777257 2085 3180 An oral anasthetic. SGTC_2322 7413319 38.22 µM 0.141015449001075 0.445086263460876 no 1478 0.443928868880736 2057 1840400 SGTC_3102 9121669 49.47 µM 0.139356777303477 0.445743118517006 no 1479 0.444584112864203 2056 41905072 SGTC_2319 6033012 152.6 µM 0.139133341440083 0.445831613379921 no 1480 0.444672390895429 2056 847246 SGTC_711 k292-0785 179 µM 0.138605535695314 0.446040668851447 no 1481 0.444880934343446 2125 4146315 SGTC_1840 st055363 71 µM 0.138403691922513 0.446120619932105 no 1482 0.444960689683337 1991 676033 SGTC_1164 k060-0068 93.7 µM 0.138235872950186 0.446187095328805 no 1483 0.445027002363768 2173 5963676 SGTC_1663 st014140 55.4 µM 0.136892231599176 0.446719384475213 no 1484 0.445557989657652 2181 4207120 SGTC_194 1486-1323 56.904 µM 0.136830002473643 0.44674403913738 no 1485 0.445582584066396 2023 5178754 SGTC_871 0574-0004 149 µM 0.136667425385615 0.44680845179914 no 1486 0.445646839329568 2027 9551173 SGTC_497 capsazepine 133 µM 0.136206846072871 0.446990939858377 no 1487 0.445828881612661 2004 2733484 A calcium channel blocker. SGTC_2755 lomerizine 42.69 µM 0.135355748020056 0.447328186490208 no 1488 0.446165305017291 2061 3949 A calcium channel blocker. SGTC_1671 st016596 74.5 µM 0.135093695544723 0.447432032164454 no 1489 0.446268897355599 2137 2829167 SGTC_2137 5261020 140 µM 0.134399535876104 0.44770712988222 no 1490 0.446543324311265 2091 763655 SGTC_1675 st018485 24.5 µM 0.133422401599075 0.448094413948885 no 1491 0.446929664938635 2029 3323024 SGTC_1962 st076595 64.5 µM 0.132855203550951 0.448319243814129 no 1492 0.447153947573034 2118 279619 SGTC_2368 9071271 200 µM 0.132176562236504 0.448588270136043 no 1493 0.447422319538942 2046 27209959 SGTC_1866 st057638 64 µM 0.131839511135189 0.44872189239672 no 1494 0.447555616970128 2073 688802 SGTC_184 1494-0393 24.714 µM 0.131285050409039 0.448941718288177 no 1495 0.447774908737476 2063 3090647 SGTC_2267 7931562 200 µM 0.130527340420035 0.449242151326003 no 1496 0.448074612323449 1927 934880 SGTC_964 1287-0107 19.4 µM 0.129777245100782 0.449539593802862 no 1497 0.448371333211148 2157 51516812 YPR165W RHO1 SGTC_1066 ketoconazole 628 nM 0.128026626997798 0.450233893182965 no 1498 0.449063950568585 2136 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W SGTC_246 cycloheximide 667 µM 0.124984668313266 0.451440702494888 no 1499 0.450267844035116 2077 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells. SGTC_2905 7799065 20.05 µM 0.124606489825494 0.451590765496957 no 1500 0.450417545154168 2175 1296806 SGTC_2259 7964009 200 µM 0.124229076019676 0.451740531966327 no 1501 0.450566950608796 2145 313134 SGTC_2966 9084041 48.03 µM 0.123659490536493 0.451966569570729 no 1502 0.450792443635463 1966 17741380 SGTC_3258 9138477 49.47 µM 0.122905743584778 0.452265714805122 no 1503 0.45109086869531 2205 4970355 SGTC_2023 5144124 124 µM 0.122198019943836 0.452546619093305 no 1504 0.451371097280058 2098 2830192 SGTC_2268 7933382 153.85 µM 0.121397993747009 0.452864188004769 no 1505 0.451687902943387 2196 935025 YOR257W CDC31 SGTC_2337 9009472 200 µM 0.121211285796885 0.452938305725281 no 1506 0.45176184262811 2183 5742383 SGTC_3112 9123419 49.47 µM 0.120802719680244 0.453100500513847 no 1507 0.451923647945173 2218 17015854 SGTC_289 k017-0060 526 µM 0.118076394158948 0.454183010991048 no 1508 0.453003563661133 2154 5512909 SGTC_2091 4-phenylthiadiazole 200 µM 0.115642954323774 0.455149516530631 no 1509 0.453967759317535 2121 270010 SGTC_1158 4092-0494 91.8 µM 0.115453888503503 0.455224620254802 no 1510 0.454042683818769 2150 1148199 SGTC_2125 5246583 200 µM 0.114979980435034 0.45541288056233 no 1511 0.454230495044718 2197 835267 SGTC_2840 9008771 71.43 µM 0.114910659734059 0.45544041909911 no 1512 0.454257967910816 2198 2992978 SGTC_673 1082-0474 110 µM 0.114661577785126 0.455539371861108 no 1513 0.45435668474512 2153 3098046 SGTC_3303 9125618 40.5795 µM 0.114236331430603 0.455708315810607 no 1514 0.454525226047282 2149 22695467 SGTC_2450 5739737 12.93 µM 0.113562882600441 0.455975883225858 no 1515 0.454792156168234 2106 2262825 SGTC_790 1575-0012 79.1 µM 0.111862208289502 0.456651665379529 no 1516 0.455466330947528 2220 378741 YLR208W SEC13 SGTC_3213 9129884 49.47 µM 0.111730034250947 0.456704191503613 no 1517 0.455518732268886 2092 17190742 SGTC_2258 7960471 200 µM 0.111655501522541 0.456733811234387 no 1518 0.45554828163126 2050 2974708 SGTC_1759 st043059 70 µM 0.111381309394225 0.45684277881544 no 1519 0.455656990387517 2095 669426 SGTC_362 0310-0100 9.03 µM 0.110468627696474 0.457205513936087 no 1520 0.456018864517686 2114 790235 SGTC_2496 diffractaic acid 79.83 µM 0.109835409394804 0.457457200428103 no 1521 0.456269954142846 2212 94870 An apoptosis inducer which activates caspases. SGTC_1919 st067113 52.3 µM 0.109529074961075 0.45757896589286 no 1522 0.456391431002806 2119 1268243 SGTC_1907 st060210 83.7 µM 0.109211488313715 0.457705208225724 no 1523 0.45651737422899 2180 688793 SGTC_2045 5106652 78.05 µM 0.10869036091245 0.457912368299978 no 1524 0.45672404371839 2198 673349 SGTC_2196 6573537 42.6665 µM 0.108686350607078 0.457913962532593 no 1525 0.456725634176793 2223 2903087 SGTC_1285 0929-0069 65.5 µM 0.108351804459481 0.458046958372573 no 1526 0.456858315222713 2122 1206237 SGTC_162 k030-0015 37.8 µM 0.107683805891118 0.458312529290004 no 1527 0.457123257917276 2186 1809920 YMR134W ERG29 SGTC_899 1083-0020 478 µM 0.10631704001563 0.458855961474669 no 1528 0.457665406118363 2193 767123 SGTC_823 0417-1665 178 µM 0.106236720776293 0.458887899163281 no 1529 0.457697268411088 2123 3429856 SGTC_1116 jasmonic acid  1.58368 µM 0.105895032336649 0.459023769187464 no 1530 0.457832817764193 2190 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid. SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM 0.104447875892198 0.459599273731343 no 1531 0.458406965475692 2238 1241132 A phosphatase inhibitor. SGTC_1017 4239-0030 168 µM 0.103940062365286 0.459801240922234 no 1532 0.458608457051226 2033 1149593 SGTC_2721 ifenprodil 61.44 µM 0.102608726438838 0.460330787900531 no 1533 0.45913675835209 2206 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor. SGTC_2355 9061122 103.12 µM 0.102430759622209 0.460401580638747 no 1534 0.459207384710691 2210 5302957 SGTC_133 0724-0033 378.92 µM 0.101431515702646 0.460799089294745 no 1535 0.459603959782665 2235 280309 SGTC_1109 tnp00067 928.257 nM 0.100327430368238 0.461238350395152 no 1536 0.460042190534354 2099 676295 SGTC_755 1995-0008 37.3 µM 0.100235545044502 0.461274909172768 no 1537 0.460078663619542 2228 689533 SGTC_2190 6049624 200 µM 0.0995056706506274 0.461565318787169 no 1538 0.460368392859581 2204 2265554 SGTC_1766 st045414 44.774 µM 0.0967360323699691 0.462667514894678 no 1539 0.461468012156922 2238 253960 SGTC_841 0251-0215 91.2 µM 0.0953327746300631 0.463226060671637 no 1540 0.462025255402769 2168 3888614 SGTC_3009 9080819 71.4286 µM 0.0949373716654209 0.463383458054423 no 1541 0.462182286134202 2145 17027216 SGTC_2817 7995342 71.43 µM 0.0929416046506482 0.46417799659975 no 1542 0.462974976520973 2159 18879975 SGTC_1235 benzylparaben 21.5 µM 0.0925833336941781 0.46432064373976 no 1543 0.463117292328582 2189 7180 SGTC_1633 st005664 67.9 µM 0.0910750458821298 0.46492122517581 no 1544 0.463716480361304 2210 2063822 SGTC_2273 7815444 169.05 µM 0.0909783054981143 0.464959748734763 no 1545 0.463754914629997 2261 2824616 SGTC_872 0588-0139 234 µM 0.0902846768157806 0.465235972301693 no 1546 0.464030498274073 2259 2047100 SGTC_725 1497-0963 19 µM 0.0881209600152814 0.466097735702182 no 1547 0.464890268749633 2249 3549977 SGTC_581 0958-0271 211 µM 0.0868682588214538 0.466596733460794 no 1548 0.465388114953835 2219 4591145 SGTC_1331 1472-0049 76.2 µM 0.0856204608665695 0.467093830279472 no 1549 0.465884066383714 2241 24051409 SGTC_852 0418-0143 439 µM 0.0855471145490663 0.467123051535507 no 1550 0.465913220364718 2256 5369229 SGTC_2423 st077119 87.2 µM 0.0844994465375661 0.467540462924612 no 1551 0.466329671434026 2246 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae). SGTC_2602 kawain 100 µM 0.0836995824487987 0.467859168446563 no 1552 0.466647644569748 2288 5369129 SGTC_1747 st037496 66.6 µM 0.082416455091433 0.468370472971467 no 1553 0.46715777564674 2210 723305 SGTC_110 0850-0284 111.64 µM 0.0824117740803598 0.468372338371154 no 1554 0.467159636768777 2279 3906265 SGTC_3278 9139605 49.47 µM 0.0822757470304069 0.468426545941112 no 1555 0.467213720043394 2214 7958859 SGTC_83 0170-0301 39.027 µM 0.0817036691746894 0.468654528687569 no 1556 0.467441180269009 2262 3089716 SGTC_765 1319-0117 244 µM 0.0813619067443866 0.468790731732987 no 1557 0.467577071325791 2276 3487746 YGL099W LSG1 SGTC_2573 2',4'-dihydroxychalcone 15.04 µM 0.0811437394893902 0.46887768013652 no 1558 0.467663820634287 2188 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_2134 5324836 1.464 µM 0.0809011498721558 0.468974363573939 no 1559 0.467760282749597 2220 699272 SGTC_515 4092-1064 102 µM 0.08002878790785 0.469322056160279 no 1560 0.468107179977936 2264 717353 SGTC_189 3970-0742 2.116 µM 0.0799459365842988 0.469355078984522 no 1561 0.468140127306969 2279 2891807 SGTC_3288 9119690 36.221 µM 0.0792359319742302 0.469638080760003 no 1562 0.468422482421634 2180 17595618 YKL019W RAM2 SGTC_403 arphamenine a 50 µM 0.0781969129263036 0.47005225248923 no 1563 0.468835708814032 2246 5487158 An arginine aminopeptidase inhibitor. SGTC_1165 k072-0275 30.3 µM 0.0754733691701547 0.471138058784265 no 1564 0.469919042706674 2268 6153523 YGL055W OLE1 SGTC_2717 st081029 62.2815 µM 0.0753598497858225 0.471183320734498 no 1565 0.469964201781079 2266 5292846 SGTC_3193 9111931 49.47 µM 0.0748504383045588 0.47138643561709 no 1566 0.470166855188207 2223 17087244 SGTC_3090 9117696 49.47 µM 0.0748234531187315 0.471397195482215 no 1567 0.470177590615399 2253 7923821 SGTC_1149 3909-7961 23.3 µM 0.0746574947943279 0.471463368884812 no 1568 0.470243613742777 2117 735261 SGTC_2569 tetrandrine 100 µM 0.0738053026277328 0.471803180150439 no 1569 0.470582653824468 2141 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_638 3970-0837 4.09 µM 0.0732376636705221 0.472029537349803 no 1570 0.47080849778645 2201 4118451 YLR208W SEC13 SGTC_1955 wogonin 32.4 µM 0.0730434018228184 0.4721070051613 no 1571 0.470885790035218 2246 5281703 A flavanone. SGTC_1893 st059353 36.1 µM 0.0718319342364711 0.472590138347992 no 1572 0.471367829304857 2132 3112488 SGTC_2845 9003024 42.97 µM 0.071320028570601 0.472794298452962 no 1573 0.471571527661791 2250 2990173 SGTC_2192 5915882 198.485 µM 0.0709793031528968 0.472930191785428 no 1574 0.471707113814381 2262 2876149 SGTC_832 4083-0019 164 µM 0.0693404071140169 0.47358388516389 no 1575 0.472359331447868 2243 1990758 SGTC_1590 st077108 57.8 µM 0.0687604309285728 0.473815232767334 no 1576 0.47259015752539 2272 5489485 SGTC_975 1335-0046 28.5 µM 0.0684860295973617 0.47392469222384 no 1577 0.472699370365192 2219 16486740 SGTC_1153 4055-0057 267 µM 0.0669700181674998 0.474529468670932 no 1578 0.473302785817136 2189 882706 SGTC_2481 5478948 45.16 µM 0.0661061648828776 0.474874108589803 no 1579 0.473646651361632 2199 77792 SGTC_99 0109-0120 622.8 µM 0.0642378128766081 0.475619563812129 no 1580 0.474390434617121 2278 759414 SGTC_2017 5132927 60.65 µM 0.0641410764035751 0.475658163119185 no 1581 0.474428947462526 2264 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis SGTC_3035 9091303 49.47 µM 0.0638902891169971 0.475758232079704 no 1582 0.474528792322031 2290 25237002 SGTC_220 paclitaxel 373.376 µM 0.0597970828746601 0.477391711846688 no 1583 0.476158624475034 2280 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_777 1315-0167 517 µM 0.0596283039176178 0.477459074972036 no 1584 0.476225837602326 2119 4221767 SGTC_1068 loratadine 26.9 µM 0.0573969986537982 0.478349694232864 no 1585 0.47711447689504 2198 3957 A H1 histamine antagonist. SGTC_3208 9114115 49.47 µM 0.0567727510053993 0.478598880484917 no 1586 0.477363110232581 2167 650895 SGTC_1514 1189-1591 158 µM 0.0567594085149405 0.478604206612167 no 1587 0.477368424546858 2285 767698 YMR146C TIF34 SGTC_186 3455-3465 67.277 µM 0.0560159245620938 0.478901000554532 no 1588 0.477664560556782 2315 755278 SGTC_1693 xanthone 101.9 µM 0.0557990287028695 0.478987586177938 no 1589 0.477750954361519 2232 7020 An insecticide. SGTC_171 k064-0041 9.68 µM 0.055432654584445 0.479133846321404 no 1590 0.477896890613066 2222 53325 SGTC_224 benfluorex 43.875 µM 0.054413880980326 0.479540565450132 no 1591 0.478302709908337 2310 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis. SGTC_1691 st019933 84.6 µM 0.0537310353589543 0.479813185932364 no 1592 0.47857472793426 2317 6176082 SGTC_1422 4031-0024 15.5 µM 0.0533734665647181 0.479955946099452 no 1593 0.478717172842305 2314 782427 SGTC_203 k066-0004 30.888 µM 0.0526255331290202 0.480254568543537 no 1594 0.479015136329964 2320 6795412 SGTC_3023 9089636 49.47 µM 0.0522244849378576 0.480414696981526 no 1595 0.479174911696064 2333 17249241 SGTC_2153 5569715 200 µM 0.0520927761695942 0.480467285664846 no 1596 0.479227384467134 2316 2054701 SGTC_524 r073-0010 27.8 µM 0.0499912950946007 0.48130641049819 no 1597 0.480064662578961 2296 2772106 SGTC_1067 clotrimazole 1.36 µM 0.0499731088642682 0.481313672656609 no 1598 0.480071908778205 2254 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_1386 3228-0095 33.8 µM 0.0498659340987712 0.48135647000386 no 1599 0.480114612082938 2295 870181 SGTC_1506 4226-2149 212 µM 0.0487148596333674 0.481816133940912 no 1600 0.480573266830472 2230 991114 SGTC_1507 4075-3230 155 µM 0.0475026937773173 0.482300219910302 no 1601 0.481056291718681 2324 659771 SGTC_3068 9116768 49.47 µM 0.0456990532469563 0.483020563057149 no 1602 0.481775059211072 2262 41904888 SGTC_659 k018-0002 107 µM 0.0455012468888373 0.483099566945094 no 1603 0.481853890528026 2322 6797879 YHR007C ERG11 SGTC_1120 ficusin 1.78878 µM 0.0448393907088789 0.483363917205954 no 1604 0.482117663703822 2261 6199 A DNA cross-linker. SGTC_1578 josamycin 24.2 µM 0.0418766589181781 0.484547342219849 no 1605 0.483298511778365 2229 5282165 A P450 substrate. SGTC_2680 butyl paraben 22.24 µM 0.0403082050456112 0.485173896666357 no 1606 0.483923706208175 2332 7184 An antifungal and steroid mimetic. SGTC_1045 1348-1485 165 µM 0.0393195755860184 0.48556884601648 no 1607 0.484317799811486 2335 6810614 SGTC_2176 5809774 33.9695 µM 0.0390795136162088 0.485664750952814 no 1608 0.484413497128224 2333 2870539 SGTC_2885 9057732 51.95 µM 0.0389267780870962 0.485725769342777 no 1609 0.484474383459305 2292 6471414 SGTC_1172 0370-0043 85 µM 0.0388124424768965 0.485771447046658 no 1610 0.484519962323999 2292 376585 SGTC_3200 9114385 49.47 µM 0.037721082276968 0.486207460747101 no 1611 0.484955033365604 2279 17018030 YLR208W SEC13 SGTC_1550 gossypolone 36.6 µM 0.0373266425879619 0.486365049016667 no 1612 0.485112281288917 2330 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_2515 chrysin 20.77 µM 0.0371569582387878 0.486432842706385 no 1613 0.485179928621982 2330 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor. SGTC_408 cantharidin 100 µM 0.0366486053867373 0.486635946366753 no 1614 0.485382594022432 2260 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_2775 cyproheptadine 69.59 µM 0.0356804618381142 0.487022761054867 no 1615 0.485768574912777 2337 2913 A selective serotonin reuptake inhibitor. SGTC_173 1273-0061 2.693 µM 0.0352356212557993 0.487200497978233 no 1616 0.485945929101298 2297 2847414 YPL266W DIM1 SGTC_2855 9016525 58.44 µM 0.032700458174186 0.488213474814032 no 1617 0.48695672925887 2348 43811474 SGTC_1834 st055981 52.8 µM 0.0323131577087014 0.488368235582573 no 1618 0.487111158175305 2344 471719 YDL150W RPC53 SGTC_359 0081-0058 15.9 µM 0.0322923938006179 0.488376532648799 no 1619 0.487119437455431 2320 3494159 SGTC_2811 7967822 32.47 µM 0.0315435017765266 0.488675786331403 no 1620 0.487418049995008 2333 2232244 SGTC_3212 9128307 49.47 µM 0.0311919753763565 0.48881625681399 no 1621 0.487558219762055 2253 27243542 SGTC_55 0767-0285 6.563 µM 0.0310595635004383 0.488869169161044 no 1622 0.487611018875304 2353 3116166 SGTC_1525 8-methoxypsoralen 92.5 µM 0.0310183474509822 0.48888563930919 no 1623 0.487627453781323 2354 4114 Related to psoralen; DNA damaging agent. SGTC_2543 pimpinellin 60.67 µM 0.0310137737491214 0.488887466985457 no 1624 0.487629277546935 2353 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo. SGTC_491 tetrandrine 80.3 µM 0.0302561886722953 0.489190205315136 no 1625 0.487931368468118 2333 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_3210 9128157 49.47 µM 0.029566278636543 0.489465905466256 no 1626 0.488206479649572 2209 17590849 SGTC_2049 5262831 67.185 µM 0.0295154261428824 0.489486227215447 no 1627 0.488226758009347 2321 763417 SGTC_354 2783-3500 4.88 µM 0.0287395963882015 0.489796268810098 no 1628 0.488536138024441 2336 6740761 SGTC_3132 9126706 49.47 µM 0.0282682831426277 0.489984620770409 no 1629 0.488724088435699 2312 850858 SGTC_965 1291-5240 308 µM 0.0262424465780908 0.490794235247259 no 1630 0.489531980027523 2358 2834598 SGTC_1229 0139-0193 12.2 µM 0.0261610226585073 0.490826776685506 no 1631 0.489564452323141 2364 3090752 SGTC_1101 ebselen 5.29 µM 0.0256362195202356 0.49103651809219 no 1632 0.489773748278278 2376 3194 A potent scavenger of hydrogen peroxide and hydroperoxides. SGTC_2060 5238662 140 µM 0.0255647866850546 0.491065066939345 no 1633 0.489802236519511 2319 790130 SGTC_395 anisomycin 6.25 µM 0.0247704743038111 0.491382524879398 no 1634 0.490119020960864 2279 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_3173 9105693 49.47 µM 0.0237134103903555 0.491805003538205 no 1635 0.490540604534822 2346 17096658 SGTC_2320 7373003 200 µM 0.0233196706734634 0.491962372582972 no 1636 0.490697640525721 2345 5415828 SGTC_2895 9054447 58.44 µM 0.0216388845592873 0.492634159337301 no 1637 0.491368007696417 2350 2697450 SGTC_723 4182-0001 115 µM 0.0206379716989751 0.493034220286732 no 1638 0.49176722493702 2334 744821 YLR208W SEC13 SGTC_430 0958-0115 16.4 µM 0.019702273390646 0.49340822157966 no 1639 0.492140438614601 2313 6833180 SGTC_393 acivicin 6.25 µM 0.0190814662073882 0.493656363206221 no 1640 0.492388058281606 2363 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1 SGTC_198 3454-2873 16.191 µM 0.0189150435507934 0.493722884102406 no 1641 0.492454439335001 2351 710957 SGTC_1792 st045773 43.6 µM 0.0186657663395858 0.493822523166435 no 1642 0.492553868999007 2359 2919270 SGTC_2929 9013348 24.6 µM 0.0182459903782415 0.493990313475076 no 1643 0.49272130685833 2373 2995952 SGTC_1135 dihydrocapsaicin 536.708 nM 0.0181878367288081 0.494013558384662 no 1644 0.492744502958644 2371 107982 A Capsaicinoid. SGTC_776 4476-4378 112 µM 0.017897832402259 0.494129477883624 no 1645 0.492860179115234 2259 2892008 SGTC_1813 st051246 8.6015 µM 0.0177817162719341 0.494175891550177 no 1646 0.492906495378195 2373 5291959 SGTC_684 1140-0066 328 µM 0.0167221246544827 0.49459943258354 no 1647 0.493329148353065 2355 6813534 SGTC_3109 9122853 49.47 µM 0.0165348905144609 0.49467427464997 no 1648 0.493403833641519 2316 1234709 SGTC_3072 9116419 49.47 µM 0.0162457067494386 0.494789868843113 no 1649 0.493519185776542 2370 17170162 SGTC_1729 st035615 45.989 µM 0.0156802046342411 0.495015915847251 no 1650 0.493744759735193 2241 17385451 SGTC_416 estradiol valerate 100 µM 0.0146435046645014 0.495430317909978 no 1651 0.494158295631769 2358 13791 A steroid. SGTC_2853 9015042 58.44 µM 0.0146307356207273 0.495435422135941 no 1652 0.494163389197545 2370 6457456 SGTC_2402 5553605 200 µM 0.0124209667046095 0.496318753305274 no 1653 0.49504487863143 2378 6758546 SGTC_2261 9010538 184.68 µM 0.0123572350845164 0.496344229618109 no 1654 0.495070301918096 2307 6457250 SGTC_1738 st035555 74 µM 0.0121080660448479 0.496443833510996 no 1655 0.495169698545708 2376 5331140 SGTC_1327 1436-0082 2.18 µM 0.0116386236100532 0.49663149102609 no 1656 0.495356965778855 2346 15992205 SGTC_1832 st054113 55 µM 0.0113897428846562 0.496730980288646 no 1657 0.495456248241262 2386 1251267 SGTC_2308 7584454 197.62 µM 0.0109322824916026 0.496913849122466 no 1658 0.495638737165557 2378 893577 SGTC_675 1309-0189 238 µM 0.0106580902459957 0.497023457211547 no 1659 0.495748117671373 2372 4246530 SGTC_286 k060-0067 22.9 µM 0.0105755160190004 0.497056466224558 no 1660 0.495781058165263 2382 5985051 SGTC_1942 st076330 65.2 µM 0.0103277089247974 0.497155527127821 no 1661 0.495879913492833 2373 24208414 SGTC_2276 7947513 42.08 µM 0.0102971192825781 0.497167755351726 no 1662 0.495892116345577 2359 2105100 SGTC_1047 2043-3044 82 µM 0.00970612583514876 0.497404005769646 no 1663 0.496127876823622 2383 669592 SGTC_3011 9081274 71.4286 µM 0.00962846823732235 0.49743504956729 no 1664 0.49615885627513 2373 6625322 SGTC_1091 telmisartan 47.6 µM 0.00921763161413248 0.497599282676142 no 1665 0.496322749096805 2360 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension. SGTC_1971 st069429 63.5 µM 0.00842191420406179 0.497917374106878 no 1666 0.496640182060019 2382 1246522 YGL099W LSG1 SGTC_700 3453-2283 142 µM 0.00821128693491464 0.498001573486582 no 1667 0.496724207277044 2380 565664 SGTC_1273 0849-0096 14.1 µM 0.00776838532046989 0.498178626066608 no 1668 0.496900893815958 2384 5286025 SGTC_1203 3992-3522 103 µM 0.00577543308121179 0.498975324627745 no 1669 0.497695948365131 2396 5322312 SGTC_989 1501-0895 10.3 µM 0.00568037421811843 0.499013325294133 no 1670 0.497733870742631 2399 2830112 SGTC_295 k015-0027 31 µM 0.00561318982571663 0.499040182886516 no 1671 0.497760673010024 2381 3887424 SGTC_1255 0566-0045 221 µM 0.00469480511291396 0.499407316192718 no 1672 0.498127050622557 2392 2788469 SGTC_1377 2944-0135 198 µM 0.00418161118795335 0.499612470741595 no 1673 0.498331783358631 2394 1894137 SGTC_2256 7954252 200 µM 0.00398858369468011 0.499689635496451 no 1674 0.498408789544315 2370 2972920 SGTC_2916 7875993 68.79 µM 0.00394168921865352 0.499708382054493 no 1675 0.49842749758645 2399 1299250 SGTC_388 3',4'-dichloroisocoumarin 16.7 µM 0.00345742532779836 0.499901971647975 no 1676 0.498620689603409 2397 1609 A potent and irreversible inhibitor of serine proteases. SGTC_984 1492-0255 2.91 µM 0.00321220767604692 0.5 no 1677 0.498718516748379 2400 1585198 SGTC_1524 corynanthine 62.1 µM 0.00285432978558868 0.49985693452662 no 1678 0.498861288712538 2369 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist. SGTC_2165 5727197 32.143 µM 0.00268462337259585 0.499789092597684 no 1679 0.498928991516214 2393 1361712 SGTC_1102 cgs 12066b 26.1 µM 0.00257378838139726 0.499744785143852 no 1680 0.498973208127499 2387 6438352 A 5-HT1B full agonist. SGTC_2759 disulfiram 3.38 µM 0.00184368428866472 0.49945291845543 no 1681 0.499264476802235 2400 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_1979 st071809 45.3 µM 0.00132012161257205 0.499243619013104 no 1682 0.499473347826441 2400 4976333 SGTC_3062 9077494 49.47 µM 0.00119469392996905 0.499193478064998 no 1683 0.499523386192574 2384 16459633 SGTC_3337 9144342 33.5465 µM 0.000887378762825305 0.499070625863865 no 1684 0.499645987139239 2402 17682949 SGTC_318 1488-0629 67.2 µM 0 0.498715888183308 no 1685 0.5 2406 3662576 SGTC_1015 4130-4525 82 µM 0 0.498715888183308 no 1686 0.5 2406 1363237 SGTC_658 3253-0951 102 µM -0.000366164887689363 0.498569510739971 no 1687 0.499853921347967 2407 1184878 SGTC_2160 5660466 132.927 µM -0.00106154539769212 0.498291527174234 no 1688 0.499576504737833 2407 2859134 SGTC_1935 st074532 41.6 µM -0.00139263216729674 0.498159173042196 no 1689 0.499444420327002 2413 2829742 SGTC_505 gw-5074 63.9 µM -0.00150656344576734 0.498113628304115 no 1690 0.49939896837074 2412 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases. SGTC_561 1550-0330 72.9 µM -0.00204553166714442 0.497898172744434 no 1691 0.499183951501161 2410 6812934 SGTC_842 0271-0008 11.1 µM -0.00308423901337509 0.497482945459742 no 1692 0.498769568605454 2415 1221709 SGTC_2674 ligustilide 100 µM -0.00322867504960446 0.497425206800567 no 1693 0.498711947250886 2418 5319022 A signalling regulator. SGTC_3043 9092303 49.47 µM -0.00420596746004671 0.497034533244484 no 1694 0.498322066697348 2413 25236084 SGTC_1317 1273-0028 910 nM -0.00440588086847751 0.496954618010425 no 1695 0.498242313525793 2416 5917803 YLR359W | YHR072W ADE13 | ERG7 SGTC_1480 1070-0044 41.2 µM -0.00443594673953783 0.496942599211665 no 1696 0.498230319095844 2437 3124987 SGTC_1424 4048-1941 275 µM -0.00449995456255608 0.496917012164343 no 1697 0.498204783923845 2414 X1424 SGTC_1589 2',5'-dimethoxyflavone 47.2 µM -0.00648573318449467 0.496123206463404 no 1698 0.497412584953137 2417 688667 SGTC_2950 9072895 21.46 µM -0.00685601081165227 0.495975191320327 no 1699 0.49726486883978 2426 17332245 SGTC_1925 st057770 10.1 µM -0.00797599517277904 0.495527491125835 no 1700 0.496818072034523 2424 5989122 SGTC_851 0394-0702 453 µM -0.00815988804660777 0.495453982698325 no 1701 0.496744711779801 2422 762646 SGTC_3249 9135183 49.47 µM -0.0082561617626637 0.495415498780817 no 1702 0.496706305417762 2444 4902779 SGTC_1191 1487-1166 10.6 µM -0.00842164095638564 0.495349351152113 no 1703 0.496640291066204 2444 3955771 SGTC_2412 st077135 33.4 µM -0.00898774826582105 0.495123059898087 no 1704 0.496414455484378 2466 13258915 SGTC_2570 licareol 100 µM -0.00949952941118615 0.494918485903405 no 1705 0.496210293071908 2439 443158 SGTC_2954 9074818 52.69 µM -0.011286411273448 0.494204227431729 no 1706 0.49549746894027 2438 16648742 SGTC_2587 piperic acid 92.2 µM -0.0153005042439447 0.492599771810198 no 1707 0.493896220101228 2439 5370536 SGTC_1216 1165-0504 9.65 µM -0.0155691711864372 0.492492388102843 no 1708 0.493789050265365 2434 6304004 SGTC_2043 5101342 149 µM -0.0165725773890559 0.49209134074006 no 1709 0.493388800813663 2444 678451 SGTC_1098 clofazimine 15.1 µM -0.0169531324422899 0.491939240300516 no 1710 0.493237002642456 2490 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2 SGTC_631 k072-0230 41.5 µM -0.0170424286363019 0.491903550520686 no 1711 0.493201383761154 2457 5773147 SGTC_119 0121-0043 24.815 µM -0.0171964933891946 0.491841974284998 no 1712 0.493139929823362 2429 1092378 SGTC_608 k048-0125 159 µM -0.0172954058685155 0.491802441281818 no 1713 0.493100475321087 2431 6817652 YLR060W | YFL022C FRS1 | FRS2 SGTC_976 1348-1067 47.6 µM -0.0173220868414592 0.491791777535109 no 1714 0.493089832747236 2434 5310671 YGL099W LSG1 SGTC_2034 5197015 53.07 µM -0.0175140229290564 0.491715065445129 no 1715 0.493013272941445 2458 780676 SGTC_2642 cholecalciferol 100 µM -0.0175983482096179 0.491681362820325 no 1716 0.492979637205729 2430 9821465 A vitamin D precursor, similar to steriods. SGTC_440 fluspirilene 35.1 µM -0.0176251721777655 0.491670641989285 no 1717 0.492968937650198 2564 3396 An atypical antipsychotic. SGTC_943 3253-1379 105 µM -0.0195178224133849 0.49091421536076 no 1718 0.492214009760589 2455 668464 SGTC_2487 5918373 44.05 µM -0.0200572348620261 0.490698636785934 no 1719 0.491998857456026 2438 2876279 SGTC_1701 st028638 40.4 µM -0.0202270429396745 0.490630772794722 no 1720 0.491931127574975 2447 3490878 SGTC_320 4092-0846 5.34 µM -0.0216354446347633 0.490067914094292 no 1721 0.491369379706548 2480 1359356 SGTC_3093 9117344 49.47 µM -0.0218300379878325 0.489990147639148 no 1722 0.491291766521632 2547 24824913 SGTC_464 bw-b 70c 158 µM -0.0226549378169124 0.489660492461269 no 1723 0.490962760506396 2513 5353454 SGTC_2588 indole-3-carbinol 100 µM -0.0226630999523233 0.489657230657469 no 1724 0.490959505121298 2465 3712 Induces cell cycle arrest. SGTC_1419 3993-2473 62.6 µM -0.0243709873561592 0.488974729518011 no 1725 0.490278345092785 2457 704026 SGTC_1257 0669-0121 16 µM -0.0243968755448698 0.488964384396512 no 1726 0.490268020269648 2484 4307855 SGTC_1417 3966-0327 90.4 µM -0.0244191971682663 0.488955464508205 no 1727 0.490259117882512 2450 651118 SGTC_1513 0337-0559 19 µM -0.0251769566652354 0.488652661429616 no 1728 0.48995690852332 2474 775073 SGTC_2201 6605497 169.863 µM -0.0256926154219514 0.488446606297659 no 1729 0.489751256976951 2496 670741 SGTC_2862 9027634 71.43 µM -0.0262119482927835 0.488239086121732 no 1730 0.48954414289908 2447 5012562 SGTC_1128 3448-9350 235 µM -0.0267111223322215 0.488039624211877 no 1731 0.489345070980095 2500 619386 SGTC_2234 tolnaftate 200 µM -0.0268954890282814 0.487965955002143 no 1732 0.489271545725691 2446 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7 SGTC_2938 9059746 27.26 µM -0.0269808298692575 0.487931854663825 no 1733 0.489237512006761 2482 6471769 SGTC_2676 harmalol 100 µM -0.0272361914803295 0.487829818262795 no 1734 0.489135674889055 2445 5459187 A monoamine oxidase inhibitor SGTC_1829 berberine 14.4 µM -0.0276799738430677 0.487652495328495 no 1735 0.488958698070799 2491 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_1245 0418-0076 17.2 µM -0.0282411681478923 0.487428261388228 no 1736 0.488734901436501 2505 6790114 SGTC_230 MPP+ 141.667 µM -0.0291330870563336 0.487071889478847 no 1737 0.488379223667872 2476 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death. SGTC_1628 st004252 77.7 µM -0.0311349464780086 0.486272071748181 no 1738 0.487580959955928 2485 692968 SGTC_2747 doxorubicin 7.63 µM -0.0312837951952869 0.486212603282936 no 1739 0.48752160682203 2457 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_66 0109-0187 42.4 µM -0.0315660757886667 0.486099826576078 no 1740 0.487409048749534 2453 759417 SGTC_2353 9059630 146.67 µM -0.0328282578965731 0.485595573466587 no 1741 0.486905771905003 2489 4779114 SGTC_821 1114-0266 29.2 µM -0.0330183485563823 0.48551963251332 no 1742 0.486829977793226 2496 3123235 SGTC_2037 5169046 200 µM -0.0340990106473128 0.485087919577085 no 1743 0.48639909870838 2523 5718022 SGTC_3354 9151612 71.43 µM -0.034721344951948 0.484839311583302 no 1744 0.486150970188781 2479 27261949 SGTC_2302 7771753 200 µM -0.0347292465811164 0.484836155105007 no 1745 0.48614781979484 2498 2203047 SGTC_3325 9138760 55.175 µM -0.0351689274605977 0.484660516480912 no 1746 0.485972519595462 2490 43844959 SGTC_742 0kpi-0133 140 µM -0.0352428340052044 0.484630993441918 no 1747 0.485943053416674 2493 2728852 SGTC_391 gliotoxin 8.33 µM -0.0381744069126058 0.4834600038428 no 1748 0.484774313171472 2529 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion SGTC_682 0kpi-0099 17 µM -0.0387444985401558 0.483232302284255 no 1749 0.484547047660344 2521 1714895 YML126C ERG13 SGTC_1199 1638-0010 4.46 µM -0.040718538953552 0.482443889158248 no 1750 0.483760140952008 2478 3111136 SGTC_2912 7964298 10.93 µM -0.0407814262923515 0.482418773660155 no 1751 0.483735073355444 2513 2975850 SGTC_298 1391-0729 10 µM -0.0415338185745147 0.482118294020885 no 1752 0.483435166390995 2476 3237558 SGTC_1485 3909-9022 254 µM -0.0424874104748189 0.481737476780479 no 1753 0.483055073837241 2468 714516 SGTC_1687 st020778 55.3625 µM -0.0453947912359836 0.480576517625843 no 1754 0.481896316350539 2496 4259299 SGTC_1944 st076371 56.9 µM -0.0460192375119027 0.480327188357442 no 1755 0.48164745841752 2489 24208455 SGTC_1304 1165-0502 251 µM -0.0480623027399978 0.47951148639666 no 1756 0.480833294760908 2514 767425 SGTC_153 4077-0274 519.67 µM -0.0491274415477631 0.479086259277978 no 1757 0.48040886730657 2505 3121976 SGTC_1212 0520-0165 585 µM -0.0498047984591166 0.478815855674128 no 1758 0.480138971406676 2574 5403258 SGTC_2104 5389443 200 µM -0.0500612771725554 0.478713470878176 no 1759 0.480036778682568 2566 2244536 SGTC_3349 9149703 23.001 µM -0.0506685597872745 0.478471052838071 no 1760 0.479794815055307 2482 4910494 SGTC_2921 7974240 10.71 µM -0.0507029291834599 0.478457333331935 no 1761 0.479781121251317 2525 2979074 YDR527W RBA50 SGTC_86 0417-1630 471.922 µM -0.0519724943079528 0.477950568913504 no 1762 0.479275305073345 2484 3634867 SGTC_3078 9116413 49.47 µM -0.0523195777112713 0.477812031959763 no 1763 0.47913702696104 2498 17177322 SGTC_2611 pyromycin 23.93 µM -0.0524211607247417 0.477771486012226 no 1764 0.479096556738026 2525 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release. SGTC_1142 3253-1408 9.78 µM -0.0525260879260692 0.477729605503711 no 1765 0.479054754431639 2479 256655 SGTC_1573 oleylamine 1.06 µM -0.0525983483222127 0.477700763724886 no 1766 0.479025966499364 2499 5356789 An amine of the fatty acid oleic acid. SGTC_534 k292-0788 63.4 µM -0.0526051673993185 0.47769804198672 no 1767 0.479023249842215 2495 4146317 SGTC_1526 st051518 75 µM -0.0535428293829821 0.477323797430335 no 1768 0.478649703328659 2578 673993 SGTC_641 4092-0595 30 µM -0.0545800184546582 0.476909852409469 no 1769 0.478236528994475 2535 786260 SGTC_855 0428-0020 25 µM -0.0549887963231506 0.476746714853732 no 1770 0.478073694763752 2537 6812414 SGTC_3081 9117243 49.47 µM -0.0557567893045972 0.476440230108312 no 1771 0.477767779250432 2592 45595589 SGTC_1784 st039334 36.3 µM -0.0567652682264514 0.476037795274047 no 1772 0.477366090623124 2632 3496984 SGTC_2485 5633444 17.78 µM -0.0571088921934475 0.475900677242255 no 1773 0.477229226519849 2546 5724239 SGTC_1019 4262-0212 3.4 µM -0.0579990940311527 0.475545468755732 no 1774 0.476874675086036 2509 4677213 SGTC_1069 diphenylcyclopropenone 8.49 µM -0.058073136637594 0.475515925134075 no 1775 0.476845186063948 2528 65057 A dermal irritant. YDR527W RBA50 SGTC_2589 lobaric acid 100 µM -0.0593166420445508 0.475019776277388 no 1776 0.476349953009429 2536 73157 A novel microtubule depolymerizer. SGTC_779 1360-0071 233 µM -0.0604497776717014 0.474567697803719 no 1777 0.475898707131797 2609 7566 SGTC_3129 9127257 49.47 µM -0.0610269011817595 0.474337459790409 no 1778 0.475668892466923 2537 837894 SGTC_2959 9079155 11 µM -0.0615377056924558 0.474133686267619 no 1779 0.475465493246602 2609 16189457 SGTC_1567 st069303 68.4 µM -0.0628182970333628 0.473622854144409 no 1780 0.474955597859108 2567 5581319 SGTC_353 1988-1175 58.3 µM -0.0630073011988741 0.473547463410175 no 1781 0.474880345179701 2470 2788357 SGTC_1765 st044815 90.4 µM -0.0632029522681552 0.473469422330534 no 1782 0.474802446955977 2577 645695 SGTC_773 4358-1457 44.6 µM -0.0638151092911357 0.47322525241269 no 1783 0.474558723653435 2510 1186886 SGTC_2662 daunorubicin 22.37 µM -0.0639213109747774 0.473182892968748 no 1784 0.474516441636911 2481 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_1799 st045822 46.1415 µM -0.063965203250062 0.473165386250324 no 1785 0.474498966913861 2514 3674992 SGTC_1239 0337-0584 35.4 µM -0.0645491781442345 0.472932469025042 no 1786 0.474266475114733 2589 914301 YML130C ERO1 SGTC_2347 9049783 174.81 µM -0.0659262630334943 0.472383258239918 no 1787 0.473718265592988 2580 6467988 YPL169C MEX67 SGTC_1585 2',4'-dihydroxychalcone 10.4 µM -0.06674653121476 0.472056142701935 no 1788 0.473391745163737 2540 5357218 A potent inhibitor of glutathione S-transferases. SGTC_1873 rapamycin 2 nM -0.0670480644662711 0.471935898692305 no 1789 0.473271719673866 2560 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1 SGTC_2456 5770359 74.46 µM -0.068465207699788 0.471370811429977 no 1790 0.472707657648535 2532 3118787 SGTC_1969 st069479 40.1 µM -0.0687146098645067 0.471271368002431 no 1791 0.472608394351144 2571 3895485 SGTC_1714 st033236 13.627 µM -0.0689838024029222 0.471164035624756 no 1792 0.472501256296092 2595 2916566 SGTC_2105 5350118 200 µM -0.0692002230442887 0.47107774596239 no 1793 0.472415122785654 2555 2133313 SGTC_3334 9142812 21.919 µM -0.0692539909993375 0.471056308205258 no 1794 0.472393723812677 2622 45283678 SGTC_1071 trifluoperazine 6.31 µM -0.0696263699898474 0.470907839728 no 1795 0.472245523826578 2642 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. SGTC_938 3126-1755 342 µM -0.0706669890806702 0.470492963678734 no 1796 0.471831397013694 2536 1777771 SGTC_1957 st077035 62.4 µM -0.0709300784180947 0.470388079762575 no 1797 0.471726702270509 2544 705593 SGTC_1778 st046819 58.9 µM -0.0709714139088983 0.470371601029093 no 1798 0.47171025324995 2534 671715 SGTC_683 panaxydol 45 µM -0.0712084450528972 0.470277107593981 no 1799 0.471615930150451 2608 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis. SGTC_2354 9060492 162 µM -0.0735349127756085 0.469349741377963 no 1800 0.470690231444704 2588 6471895 SGTC_1960 st011366 51.8 µM -0.0740426766753449 0.469147360718749 no 1801 0.470488213679873 2537 3972846 SGTC_56 0957-0365 83.25 µM -0.0750794480376306 0.468734157113936 no 1802 0.470075749877455 2528 6752360 SGTC_1043 0916-0009 19.3 µM -0.0766269664919395 0.468117458837628 no 1803 0.469460152930317 2520 3101130 SGTC_3352 9151559 45.5865 µM -0.0767809242424675 0.468056109622985 no 1804 0.469398913091687 2589 17159339 SGTC_2194 5927483 104.545 µM -0.0775971874652229 0.467730857072202 no 1805 0.469074239857302 2522 760979 SGTC_1462 k081-0014 26.5 µM -0.0802917645050228 0.466657315792652 no 1806 0.468002604020469 2520 3270634 SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM -0.0811314736027308 0.466322818098293 no 1807 0.467668697934239 2526 756377 SGTC_2671 danthron 100 µM -0.0817965665434024 0.466057895531777 no 1808 0.467404243214031 2582 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin. SGTC_987 1497-1013 404 µM -0.0819390520180846 0.466001142081262 no 1809 0.46734758990717 2532 1676435 SGTC_2544 sphondin 68.51 µM -0.0823362804021133 0.465842925527508 no 1810 0.467189652380806 2722 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31 SGTC_1908 st060353 56.5 µM -0.082601203437135 0.465737409356242 no 1811 0.467084322171382 2617 4227716 SGTC_717 1532-0246 73.2 µM -0.0832709736525073 0.465470657397723 no 1812 0.466818039893204 2598 9561992 SGTC_2432 5630864 12.22 µM -0.0846508065360031 0.464921155087735 no 1813 0.466269503106994 2651 5714970 SGTC_2780 5215298 71.43 µM -0.0860442248617364 0.464366310417928 no 1814 0.46571563060382 2587 2834131 SGTC_915 methyl methanesulfonate (MMS) 110 mM -0.0875382917193232 0.463771465552942 no 1815 0.465121824923314 2620 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks. SGTC_734 2023-0417 80 µM -0.0877803236107767 0.463675111034589 no 1816 0.465025638435585 2647 3935732 SGTC_233 rapamycin 362 pM -0.0898979998036694 0.462832141446305 no 1817 0.46418413532161 2591 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C SGTC_2501 sodium tetradecyl sulfate 13.37 µM -0.0901139233762254 0.462746199466166 no 1818 0.464098342491091 2570 23665772 A membrane-active detergent. SGTC_2973 9094665 17.96 µM -0.0903869960627032 0.46263751346531 no 1819 0.463989845016011 2790 25237061 YIL048W NEO1 SGTC_878 0828-0289 13.7 µM -0.090618025541813 0.462545563311783 no 1820 0.463898054275198 2584 745350 YLR208W SEC13 SGTC_1387 3342-1166 1.8 µM -0.0912952943843597 0.462276020630402 no 1821 0.463628978456559 2644 3418228 SGTC_390 dec-rvkr-cmk 16.7 µM -0.0918091615406884 0.462071520882116 no 1822 0.46342483247537 2623 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1 SGTC_3024 9090631 49.47 µM -0.0939803621508928 0.461207576238274 no 1823 0.462562378208307 2563 25236383 SGTC_2286 7945697 125 µM -0.0942748072494722 0.461090427294423 no 1824 0.462445430835873 2634 1245733 SGTC_3314 9135860 59.4275 µM -0.0943373898838997 0.461065528386096 no 1825 0.462420574753631 2585 25252478 SGTC_2751 anetholtrithion 17.25 µM -0.0944415275434265 0.461024096878982 no 1826 0.46237921449619 2666 2194 A chloretic substance that stimulates the liver to produce bile. SGTC_3186 9110464 49.47 µM -0.0948673820713345 0.460854673674852 no 1827 0.462210082486815 2668 17018021 SGTC_1156 4092-0367 4.88 µM -0.0957165945479537 0.460516841755084 no 1828 0.46187283043554 2595 1357585 SGTC_75 0159-0059 199.013 µM -0.0969856475210274 0.460012042959951 no 1829 0.461368896166071 2677 5377270 SGTC_2435 5706476 10.6 µM -0.0971689946445148 0.459939117186625 no 1830 0.46129609509497 2610 5725375 SGTC_2771 fluoxetine 41.05 µM -0.0972259745422642 0.459916453876058 no 1831 0.461273470528548 2673 3386 A selective serotonin reuptake inhibitor. SGTC_2547 epiafzelechin trimethyl ether 100 µM -0.0974287513145271 0.45983580205105 no 1832 0.461192956544254 2551 6708630 An antioxidant. SGTC_1619 st003326 88.7 µM -0.0975028122089659 0.459806345704959 no 1833 0.461163550526765 2653 2849032 SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM -0.0983852407122982 0.459455393166095 no 1834 0.460813197011631 2604 688798 SGTC_1421 4029-0249 71.4 µM -0.0985156017076183 0.459403549685832 no 1835 0.460761441925374 2662 2894095 SGTC_2479 5617353 43.85 µM -0.101408570896526 0.458253219214818 no 1836 0.45961306647944 2677 2731746 SGTC_1591 genipin 88.4 µM -0.101634275382214 0.458163486983409 no 1837 0.459523486242731 2743 442424 A DNA cross-linking agent. SGTC_1399 3562-5772 25 µM -0.101696439571145 0.458138773044345 no 1838 0.459498814152923 2575 23847490 SGTC_327 1273-0057 3.96 µM -0.103235992391459 0.457526761683603 no 1839 0.458887837355811 2646 3108138 SGTC_3101 9120531 49.47 µM -0.104189886702758 0.45714761489445 no 1840 0.458509329766806 2656 24824904 SGTC_3137 9097352 49.47 µM -0.104350896299309 0.457083621839868 no 1841 0.458445444467471 2782 44120435 SGTC_2349 9023730 187.07 µM -0.104756600634323 0.45692238011841 no 1842 0.458284474087572 2665 4126287 SGTC_605 1315-0399 119 µM -0.104941322833881 0.456848967117159 no 1843 0.45821118454845 2690 24020461 SGTC_2874 9043904 71.43 µM -0.105400208779257 0.45666660129278 no 1844 0.458029125203098 2671 4463428 SGTC_1688 st021091 57.6 µM -0.105879498350456 0.456476136609851 no 1845 0.457838980283618 2570 3656366 SGTC_3335 9143315 29.6265 µM -0.10613296375269 0.456375416138805 no 1846 0.457738428773266 2658 4899691 SGTC_2835 9006588 71.43 µM -0.106617558168614 0.456182858896417 no 1847 0.457546194289922 2809 2345538 SGTC_3299 9121982 43.1275 µM -0.107197008970897 0.455952623266835 no 1848 0.457316344126863 2624 17594604 YPL160W CDC60 SGTC_2103 5378138 10 µM -0.107386815394138 0.455877209892673 no 1849 0.457241056905616 2594 244142 SGTC_2094 5332512 191.667 µM -0.108574868924475 0.45540521190204 no 1850 0.456769847291478 2696 755774 SGTC_3281 9140613 49.47 µM -0.108998001695948 0.455237122000992 no 1851 0.456602037654198 2627 16013766 SGTC_2678 equilin 100 µM -0.109252041499612 0.455136208292172 no 1852 0.456501292078012 2646 3247 Equilin is an estrone commonly used hormone replacement therapy SGTC_2241 6772625 37.8075 µM -0.1095562800586 0.455015357649887 no 1853 0.456380642661607 2566 2285411 SGTC_3004 9076122 71.4286 µM -0.111479253224184 0.454251604687678 no 1854 0.455618158285998 2681 44782551 SGTC_436 n,n-dimethylsphingosine 3.3 µM -0.111762288339996 0.454139205000895 no 1855 0.455505944838442 2913 5282309 SGTC_1483 3453-0561 55.9 µM -0.114320664260527 0.453123383410328 no 1856 0.454491801087835 2685 4546991 SGTC_960 1222-0186 7.7 µM -0.115748408393887 0.452556620215342 no 1857 0.453925969854604 2726 3126296 SGTC_459 nigericin 15.3 µM -0.117069066247033 0.452032452453408 no 1858 0.453402661351069 2717 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification. SGTC_3002 9075603 71.4286 µM -0.117245704688518 0.451962351153896 no 1859 0.453332674773198 2608 20105405 SGTC_2050 5263056 171 µM -0.11759490360349 0.451823771359458 no 1860 0.453194321631453 2673 763468 YGL055W OLE1 SGTC_1953 st076800 12.1 µM -0.118580445870747 0.45143269004838 no 1861 0.452803878982722 2652 297591 SGTC_1864 st057645 30.4 µM -0.118611856502518 0.451420226504592 no 1862 0.452791435769267 2627 688666 SGTC_1453 4237-0541 195 µM -0.118730911175014 0.451372986784107 no 1863 0.452744273092285 2624 739892 SGTC_2413 inermin 26.06 µM -0.118764145042497 0.451359800036004 no 1864 0.452731107846795 2882 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1 SGTC_758 0868-0029 16 µM -0.118955479403438 0.451283882199787 no 1865 0.452655313772337 2726 762687 SGTC_281 1672-3440 14.9 µM -0.119750162872509 0.450968586010138 no 1866 0.452340531004138 2705 6833000 SGTC_3038 9091290 49.47 µM -0.119877976477987 0.450917877956481 no 1867 0.452289905435593 2672 25236843 SGTC_2790 5423970 71.43 µM -0.120466355172149 0.450684458234252 no 1868 0.452056865099201 2733 1376240 YKL165C | YIL048W MCD4 | NEO1 SGTC_586 0957-0265 8.15 µM -0.121163795588016 0.450407793989432 no 1869 0.451780649866517 2608 6752309 YPR165W | YPR107C RHO1 | YTH1 SGTC_1903 st060211 78.3 µM -0.121398225709192 0.450314804449852 no 1870 0.451687811083259 2733 688960 SGTC_1484 3473-2379 286 µM -0.121901270147174 0.450115275009068 no 1871 0.451488604849645 2613 671917 SGTC_3182 9108849 49.47 µM -0.122052528773679 0.450055281681103 no 1872 0.451428708628691 2693 17133045 SGTC_2088 5278280 127.392 µM -0.122962820723598 0.449694259029641 no 1873 0.45106826962625 2680 791502 SGTC_3144 9087057 49.47 µM -0.123618462300745 0.449434256733081 no 1874 0.450808686905557 2588 17249618 SGTC_3188 9110789 49.47 µM -0.124061563148637 0.449258552222312 no 1875 0.450633265576292 2741 849217 SGTC_848 0368-0089 85.6 µM -0.124063414844514 0.449257817982962 no 1876 0.4506325325197 2634 762535 SGTC_607 4491-0986 66.8 µM -0.124130232535746 0.449231323371455 no 1877 0.450606080583971 2711 698981 YDR232W HEM1 SGTC_951 1171-0579 82.7 µM -0.125302312635244 0.448766606023721 no 1878 0.45014211069846 2600 1616050 YPR165W | YDR526C RHO1 | YDR526C SGTC_2596 sinensetin 100 µM -0.126189518746692 0.448414884896594 no 1879 0.44979095393569 2680 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets. SGTC_672 1441-0018 53.7 µM -0.128777867019913 0.447389001138065 no 1880 0.448766709621603 2630 251141 SGTC_1093 fluphenazine 7.97 µM -0.128967093083052 0.447314015698339 no 1881 0.448691843624601 2651 6602611 An atypical antipsychotic. SGTC_2842 9000675 19.48 µM -0.129400439479579 0.447142298725211 no 1882 0.4485203999754 2712 2989072 SGTC_1007 4101-0031 70 µM -0.13012410207213 0.446855563743753 no 1883 0.448234120771148 2688 1146276 SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM -0.130280822098227 0.446793470622308 no 1884 0.448172126246725 2612 2333 A French combination drug. SGTC_2124 5246320 200 µM -0.131312729608706 0.44638465724512 no 1885 0.44776396110759 2734 579342 SGTC_2233 sulbentine 40.3845 µM -0.131484479692637 0.446316620104625 no 1886 0.447696031696845 2635 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58 SGTC_2761 levamisole 97.89 µM -0.131762024431482 0.446206676772576 no 1887 0.447586262355797 2703 26879 An alkaline phosphatase inhibitor. SGTC_2549 cedrol 20.94 µM -0.133255165381704 0.445615272529916 no 1888 0.446995792071078 2683 6708665 A sedative which affects the nervous system. SGTC_749 1000-0129 128 µM -0.13482713735931 0.444992775607322 no 1889 0.446374274615084 2785 708470 SGTC_2976 9009005 19.48 µM -0.136387311816876 0.444375084564155 no 1890 0.445757551826781 2779 2993148 SGTC_3341 9147222 25.867 µM -0.136636020743991 0.44427663027817 no 1891 0.445659251535334 2769 1939759 SGTC_613 3914-0030 117 µM -0.136783523283571 0.444218241327283 no 1892 0.445600953868174 2602 1145395 SGTC_2102 5377816 72.7585 µM -0.136923714596715 0.44416274765099 no 1893 0.445545546919029 2786 1379702 SGTC_1682 st012968 530 nM -0.136936488191813 0.444157691373898 no 1894 0.445540498542573 2666 24207270 SGTC_1175 0741-0056 27.6 µM -0.137624788505967 0.443885249266785 no 1895 0.445268481775943 2799 765927 SGTC_2307 7538926 6.34 µM -0.138619003112189 0.443491767422672 no 1896 0.444875612988343 2718 96582 SGTC_1001 4048-4355 44.4 µM -0.139627322890557 0.443092760054914 no 1897 0.44447722577237 2665 21824233 SGTC_1745 st081495 74 µM -0.141559597949002 0.442328291199076 no 1898 0.443713940817342 2677 13842402 YBL026W LSM2 SGTC_2524 avocatin b 10.57 µM -0.142568937534125 0.441929049866278 no 1899 0.443315315541638 2764 6710748 SGTC_2800 7887935 81.82 µM -0.142634583839825 0.441903085699786 no 1900 0.443289391386574 2790 2961002 SGTC_3076 9116187 49.47 µM -0.144521193922982 0.44115700826234 no 1901 0.442544460900099 2769 27241210 SGTC_1039 k821-0043 94 µM -0.145559242632502 0.440746591150904 no 1902 0.442134672438461 2705 15992768 SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM -0.146091616616995 0.440536129163433 no 1903 0.441924532192019 2766 551469 SGTC_2214 7179297 48.276 µM -0.146582701316311 0.440342004850777 no 1904 0.441730704264963 2659 769744 SGTC_89 0302-0250 142.109 µM -0.147755449229295 0.439878479200244 no 1905 0.441267884843307 2627 4203518 YLR208W SEC13 SGTC_2697 mebhydrolin 72.4 µM -0.149277961892088 0.439276832929445 no 1906 0.440667152139573 2771 22530 H1 Histamine receptor antagonist. YIL048W NEO1 SGTC_2028 5153890 36.43 µM -0.15034408643002 0.43885561943984 no 1907 0.440246576150529 2671 2830968 YPR165W RHO1 SGTC_277 nystatin 15.5 µM -0.150691380867656 0.438718422346648 no 1908 0.440109586331226 2634 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_1891 st059073 26.2 µM -0.151215247420946 0.438511485174889 no 1909 0.439902961448889 2842 688754 SGTC_2064 5220758 200 µM -0.151930582212497 0.438228941594991 no 1910 0.43962084358385 2818 788518 SGTC_1023 4482-3888 16 µM -0.152705101228098 0.437923056879828 no 1911 0.439315418876358 2872 3303168 SGTC_2069 5228469 200 µM -0.152768311809918 0.437898094439329 no 1912 0.439290493935654 2793 2835210 SGTC_455 paf C-16 10 µM -0.152831403477145 0.43787317920573 no 1913 0.43926561612488 2662 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis. SGTC_843 0310-0051 143 µM -0.153470500173734 0.437620810435219 no 1914 0.439013626072778 2693 2065037 SGTC_1139 k015-0024 46.9 µM -0.154137891097684 0.437357295824865 no 1915 0.438750506244173 2657 2766652 SGTC_553 k007-0256 45.7 µM -0.154958373792445 0.437033372094266 no 1916 0.438427066868191 2728 6287000 SGTC_2977 9011197 71.43 µM -0.154992111534664 0.4370200534523 no 1917 0.438413768119311 2901 2704722 SGTC_503 tyrphostin 8 294 µM -0.156549525068325 0.436405311557149 no 1918 0.437799942532468 2753 92970 A tyrosine kinase inhibitor. YOR207C RET1 SGTC_691 1548-0686 185 µM -0.157613027352386 0.435985614339543 no 1919 0.437380868773779 2708 46495133 SGTC_990 3985-0011 41.3 µM -0.157818338952588 0.435904599096877 no 1920 0.437299973680317 2763 5399565 YGL099W LSG1 SGTC_1094 duloxetine 25.4 µM -0.16128090315937 0.43453869112566 no 1921 0.435936081712256 2675 60834 A selective serotonin reuptake inhibitor. SGTC_708 3448-5400 146 µM -0.1614395014845 0.434476146040479 no 1922 0.43587362850096 2707 3462195 SGTC_1698 5-fluorocytosine 1.055 µM -0.162228230779202 0.434165125901868 no 1923 0.435563064654726 2718 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_2568 diosmetin 100 µM -0.162692138485765 0.433982211892252 no 1924 0.435380418550024 2705 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.  SGTC_2300 7976697 71.57 µM -0.163103046735557 0.433820206823992 no 1925 0.435218650486913 2727 2236109 SGTC_3244 9134489 49.47 µM -0.166073080171219 0.432649570890087 no 1926 0.43404971943022 2788 16584271 SGTC_907 3448-6986 75.5 µM -0.166123733874917 0.432629610875301 no 1927 0.434029788367057 2819 590582 SGTC_1612 st002233 45.4 µM -0.167499187954047 0.432087681169002 no 1928 0.433488643211072 2691 1035021 SGTC_1260 0700-1617 7.75 µM -0.167824476956583 0.431959535755366 no 1929 0.433360682887568 2797 2853078 SGTC_2993 9054257 71.4286 µM -0.168191553505644 0.431814937016765 no 1930 0.433216292808209 2696 6470217 YGL055W OLE1 SGTC_1841 st054148 70 µM -0.169008155290148 0.43149329415817 no 1931 0.432895113343011 2780 675442 SGTC_2882 9058044 58.44 µM -0.169019255267916 0.431488922414753 no 1932 0.432890747890919 2790 18076804 SGTC_3123 9126162 49.47 µM -0.171054138403946 0.43068762286879 no 1933 0.432090598275599 2705 25239884 SGTC_1716 st033144 30.6155 µM -0.171403832545722 0.430549948382596 no 1934 0.43195312072012 2798 674617 SGTC_1454 4239-0054 42.6 µM -0.172057746300702 0.430292525382297 no 1935 0.4316960654329 2897 1340767 SGTC_537 1334-0398 209 µM -0.172389623105695 0.430161888404214 no 1936 0.431565614808991 2761 5846986 SGTC_933 2914-0560 114 µM -0.173211597941497 0.429838366620898 no 1937 0.431242553797583 2914 463887 SGTC_1076 itraconazole 331 nM -0.173379941600965 0.429772113899629 no 1938 0.431176395306998 2697 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1 SGTC_1319 1306-0155 43.7 µM -0.173707855660839 0.429643066908742 no 1939 0.431047531732651 2713 3122360 SGTC_2439 5492030 7.2 µM -0.17413088611545 0.429476599007261 no 1940 0.430881300188799 2819 5722370 SGTC_443 clozapine 122 µM -0.174277675180831 0.42941883855916 no 1941 0.430823621686489 2676 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_3080 9117754 49.47 µM -0.174735782476026 0.429238586334515 no 1942 0.43064362497436 2911 9550191 SGTC_3060 1327-0027 12.5 µM -0.174763909077161 0.429227519795245 no 1943 0.430632574111624 2809 16000455 YPR107C YTH1 SGTC_2397 5161689 200 µM -0.175048388506504 0.42911559319652 no 1944 0.430520805995933 2894 2259942 SGTC_328 k915-0120 63.5 µM -0.176025761772598 0.428731095461721 no 1945 0.430136851736956 2856 6624543 SGTC_1694 st024011 44.9 µM -0.176526335326408 0.428534196456226 no 1946 0.429940230468613 2739 2787533 SGTC_3135 9127742 49.47 µM -0.177094716644507 0.428310647051103 no 1947 0.429716995921196 2800 3643468 SGTC_2693 st077581 40.7 µM -0.177379123404249 0.428198795984687 no 1948 0.429605302202958 2768 25238761 SGTC_1112 tnp00069 1.16933 µM -0.177471227356907 0.428162574715582 no 1949 0.429569131861749 2840 145826 SGTC_2659 sanguinarine 24.21 µM -0.178352588232276 0.427815996903141 no 1950 0.429223040679027 2709 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis. SGTC_2645 abamectin 100 µM -0.178904486769974 0.427599002003719 no 1951 0.429006349847491 2788 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels. SGTC_554 4483-2211 187 µM -0.180259687564114 0.427066258587578 no 1952 0.428474350937944 2829 747107 SGTC_2869 9037858 32.47 µM -0.18129316524298 0.426660077176944 no 1953 0.428068735243121 2695 27187042 SGTC_495 decylubiquinone 155 µM -0.181296896903233 0.426658610685985 no 1954 0.428067270791627 2787 2971 A Co-enzyme Q analog. A free radical scavenger. SGTC_3308 9128332 17.569 µM -0.181915547578738 0.426415503543594 no 1955 0.427824501441063 2876 17332805 YDL196W YDL196W SGTC_1079 idarubicin 2.36 µM -0.182361803286075 0.42624015868398 no 1956 0.427649399848784 2737 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_2163 5671233 125 µM -0.182939405031936 0.426013226383852 no 1957 0.427422781925522 2855 701023 SGTC_2740 felodipine 17.08 µM -0.183172958087379 0.425921473342712 no 1958 0.42733115584516 2834 3333 L-type calcium channel blocker SGTC_986 1493-0483 84 µM -0.183616828296551 0.425747106713456 no 1959 0.427157030256381 2736 40079 SGTC_1780 st038448 24.544 µM -0.184141704753295 0.425540936937618 no 1960 0.42695114508811 2925 728868 YDL195W SEC31 SGTC_425 3825-7017 13.1 µM -0.184908831959298 0.425239648483263 no 1961 0.426650271774192 2989 3397440 SGTC_2180 6301957 200 µM -0.186438641643547 0.424638947740703 no 1962 0.426050395981477 2781 845462 SGTC_2583 asiatic acid 100 µM -0.186623424837238 0.424566401903426 no 1963 0.425977949524534 2888 5320556 A kinase inhibitor; arrests cells at G2/M. SGTC_604 1000-0114 314 µM -0.18901764298137 0.423626664340026 no 1964 0.425039494471012 2885 1572745 SGTC_1309 pyrazolanthrone 13.4 µM -0.189485711590099 0.423442996629074 no 1965 0.424856076371379 2828 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14 SGTC_710 3448-4187 58 µM -0.190210337717571 0.42315868989091 no 1966 0.424572155338836 2760 3946412 SGTC_1876 myriocin 605 nM -0.191834300402242 0.422521674377697 no 1967 0.423936001040878 2861 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1 SGTC_2772 vinpocetine 57.06 µM -0.192010729977843 0.422452480292267 no 1968 0.423866900253098 2935 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor. SGTC_176 1486-1328 72.834 µM -0.192620241702091 0.422213453728102 no 1969 0.423628195603158 2825 22310231 SGTC_2123 5259487 200 µM -0.192931568393809 0.422091374672081 no 1970 0.423506280734333 2869 2173474 SGTC_2648 atorvastatin 78.68 µM -0.193055387092504 0.422042824314029 no 1971 0.423457795630498 2844 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11 SGTC_2310 7668677 200 µM -0.193266420203438 0.421960079178595 no 1972 0.423375161653258 2933 2197143 SGTC_123 0083-0120 66.675 µM -0.193929598983602 0.421700072195631 no 1973 0.423115503502357 2748 16001701 SGTC_1074 carmofur 3.8 µM -0.194137050214293 0.421618745521745 no 1974 0.423034285796261 2747 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_763 3453-1109 128 µM -0.195247243448703 0.42118357568218 no 1975 0.422599697878949 2824 1560353 SGTC_1986 st071812 45 µM -0.195347442865128 0.421144304577702 no 1976 0.422560479193423 2762 11838594 SGTC_2981 9013952 38.96 µM -0.195395942781124 0.421125296312931 no 1977 0.422541496295141 2812 2996344 SGTC_26 0302-0163 425.158 µM -0.195587254938671 0.421050318344541 no 1978 0.422466618348529 2745 3100915 SGTC_2074 5212007 75.395 µM -0.197035847362749 0.420482687381992 no 1979 0.421899742741277 2778 758611 SGTC_2375 9072683 200 µM -0.198217083865492 0.420019942148751 no 1980 0.42143761083883 2794 16798029 SGTC_1820 st053765 18.6 µM -0.19996369553288 0.419335915938679 no 1981 0.42075448720906 2818 3690829 SGTC_166 k072-0058 166.424 µM -0.202007714285759 0.418535725689216 no 1982 0.419955346690103 2785 5846229 SGTC_229 benomyl 22.8748 µM -0.202502671502588 0.41834201092865 no 1983 0.419761885059053 2842 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C SGTC_2460 5552655 174.22 µM -0.2027689697473 0.418237796170683 no 1984 0.419657806319115 2876 5401989 SGTC_2982 9019404 25.97 µM -0.203264030435629 0.418044071400153 no 1985 0.419464334093539 2781 22333232 SGTC_1061 3448-9325 110 µM -0.203651036508589 0.417892643886969 no 1986 0.419313103714648 2724 723482 SGTC_1561 5-methoxyflavone 52.9 µM -0.203879367065547 0.417803308546097 no 1987 0.419223884562546 2762 94525 SGTC_3215 9129942 49.47 µM -0.203961597264317 0.417771136655506 no 1988 0.41919175449417 2860 17682944 SGTC_1363 1636-0063 10.4 µM -0.204473064902499 0.417571041503608 no 1989 0.418991919217184 2758 6072185 SGTC_895 0964-0006 13.7 µM -0.205947320378326 0.416994406372612 no 1990 0.418416030669912 2785 6738897 SGTC_1471 k673-0312 37 µM -0.20633994471081 0.41684086671578 no 1991 0.418262689222127 2791 24099884 SGTC_1602 st001878 87.6 µM -0.207667941015738 0.416321634668582 no 1992 0.417744125650021 2950 595405 YLR310C CDC25 SGTC_3356 9151811 4.48 µM -0.208265973245886 0.416087858220824 no 1993 0.41751064925641 2765 1859254 YPR165W RHO1 SGTC_190 3970-0790 3.722 µM -0.208292880366148 0.416077340670611 no 1994 0.417500145192174 2768 2832352 SGTC_3166 9102297 49.47 µM -0.208509551669674 0.415992649617328 no 1995 0.41741556269074 2823 25237072 SGTC_1704 st028805 70.8 µM -0.208838334226622 0.41586414470722 no 1996 0.41728722234755 2823 2876101 SGTC_1458 k015-0034 6.33 µM -0.210077589407179 0.415379861850773 no 1997 0.416803558128326 2832 3598957 SGTC_1219 1469-0211 33.1 µM -0.210109803463608 0.415367274777877 no 1998 0.41679098710187 2876 6822282 SGTC_1779 st039427 55 µM -0.211940754781201 0.414652006065847 no 1999 0.416076627517194 2877 1124498 SGTC_1032 k061-1018 98.7 µM -0.213943847859992 0.413869813557095 no 2000 0.415295423063855 2985 4005393 SGTC_2564 betulinic acid 100 µM -0.213978408433871 0.413856320906452 no 2001 0.415281947400642 3062 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14 SGTC_376 3970-0862 59.1 µM -0.214739731256127 0.413559121835344 no 2002 0.414985122022291 2900 3135186 SGTC_2689 tacrolimus 100 µM -0.214755473629484 0.413552976976359 no 2003 0.414978984879949 2876 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). SGTC_1673 st016611 27.3 µM -0.214802817544315 0.413534496937465 no 2004 0.414960528045685 2989 5226799 SGTC_339 3091-4833 71.4 µM -0.217058124785863 0.412654391700134 no 2005 0.414081523760946 2805 3240077 SGTC_2015 5119600 184 µM -0.217962440821484 0.412301616797537 no 2006 0.413729187865509 2972 2828786 SGTC_489 paxilline 115 µM -0.218890406964147 0.411939689603882 no 2007 0.413367709703924 2854 105008 A toxic potassium channel blocker. SGTC_1909 st060837 51.5 µM -0.219768445793502 0.411597304112285 no 2008 0.41302574772607 2851 678937 SGTC_629 3448-6466 76.7 µM -0.220414600551803 0.411345383270058 no 2009 0.412774137705862 2831 573744 SGTC_1931 st074438 57.1 µM -0.220665677013648 0.411247504201074 no 2010 0.412676379219755 2736 2787313 SGTC_1547 harmine 94.2 µM -0.221970958567196 0.410738745393987 no 2011 0.412168245547808 2817 5280953 A monoamine oxidase inhibitor YHR072W ERG7 SGTC_2760 etidronate 98.04 µM -0.222112251951666 0.410683682546841 no 2012 0.412113250194391 2831 3305 A chelator and antioxidant. SGTC_751 0833-0568 350 µM -0.222202419226472 0.410648544759602 no 2013 0.412078155460774 2874 6954252 SGTC_2985 9022375 71.43 µM -0.223515175697589 0.410137050743711 no 2014 0.411567286684823 2998 4939335 SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM -0.224852773208948 0.409616035037562 no 2015 0.411046905000522 2981 6728940 SGTC_2070 5230947 200 µM -0.224901371841779 0.409597108088558 no 2016 0.411028001029305 2895 2835538 SGTC_2040 5100729 123 µM -0.225216815986052 0.409474262117881 no 2017 0.410905304104029 2803 11840 YJR013W | YDR381W GPI14 | YRA1 SGTC_1627 st003713 25.6 µM -0.227323969422504 0.408653884817649 no 2018 0.410085918022048 2882 16195070 YER133W GLC7 SGTC_1943 st076331 65.2 µM -0.227463737727407 0.408599482983026 no 2019 0.410031581664534 2902 24208415 SGTC_106 0092-0003 11.579 µM -0.227730286473941 0.408495739445603 no 2020 0.409927962903475 2892 1072148 SGTC_731 3966-0296 387 µM -0.227999365610874 0.408391017557819 no 2021 0.409823366852206 2820 660956 SGTC_283 0987-0079 11.7 µM -0.228232662567198 0.408300226895505 no 2022 0.409732685191494 2899 411556 SGTC_413 propylparaben 100 µM -0.228761001398506 0.408094634905013 no 2023 0.409527339705426 2805 7175 A pharmaceutical preservative. SGTC_60 0986-0278 202 µM -0.229922357541871 0.40764280648808 no 2024 0.409076051441734 2810 3110598 SGTC_1717 st033143 58.0435 µM -0.231612795801976 0.406985357044899 no 2025 0.40841938406351 2977 674616 SGTC_2087 5276107 200 µM -0.232064672741881 0.40680965624899 no 2026 0.408243891486582 2795 144405 SGTC_2708 st078559 56 µM -0.234092293196289 0.406021499250227 no 2027 0.407456664434787 2875 17250902 SGTC_1105 epirubicin 18.1 µM -0.234192197807483 0.405982675112498 no 2028 0.407417885933073 2809 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_2483 5729050 27.16 µM -0.237573587119103 0.404669174019462 no 2029 0.40610591923006 2971 2865180 SGTC_23 0213-0011 39.996 µM -0.238439009467487 0.404333172552135 no 2030 0.40577030727727 2985 627608 SGTC_958 1222-0007 33 µM -0.240732332069435 0.40344312857871 no 2031 0.404881289194143 2997 7312461 SGTC_1630 st005209 31.3 µM -0.241188452240868 0.403266166703424 no 2032 0.40470453026677 2829 3367314 SGTC_2053 5265679 138 µM -0.24199225404264 0.402954362304994 no 2033 0.404393082632547 2824 764595 SGTC_2617 dihydrotanshinone i 20.83 µM -0.243533897247375 0.402356513158186 no 2034 0.403795914584817 2837 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12 SGTC_118 0083-0097 135.343 µM -0.243752816795614 0.40227163465114 no 2035 0.403711132460292 2867 5207356 SGTC_1002 4049-0206 172 µM -0.244263178836579 0.402073777264391 no 2036 0.403513499442942 2828 4662749 SGTC_1269 0831-0796 3.05 µM -0.244433990412194 0.402007562557204 no 2037 0.403447359727696 2952 927758 SGTC_2246 7293507 91.5585 µM -0.24587297171642 0.401449856647792 no 2038 0.40289028355511 3010 887656 SGTC_1333 1482-0047 286 µM -0.246926874407876 0.401041522887672 no 2039 0.402482408714543 2966 3811116 SGTC_1359 1582-0056 520 nM -0.247078583239617 0.400982752309669 no 2040 0.402423704037836 2956 3661189 SGTC_1742 st038235 28.8875 µM -0.247623513420667 0.400771669958669 no 2041 0.402212858068676 2967 564103 YBR002C RER2 SGTC_635 k038-0028 24.7 µM -0.248307465406071 0.400506777586245 no 2042 0.401948261647834 2887 4035102 SGTC_808 0711-0032 135 µM -0.248742685479731 0.400338242083919 no 2043 0.401779914042286 2836 4252555 SGTC_244 nsc-207895 1.295 µM -0.249427971919397 0.400072907998715 no 2044 0.401514875141957 2795 42640 SGTC_1733 st037357 54.9 µM -0.249631723627881 0.399994026850779 no 2045 0.401436081600682 2799 1272339 YGL099W LSG1 SGTC_2082 5219693 150 µM -0.250214077831244 0.399768594718731 no 2046 0.401210899460905 2835 2834649 SGTC_3338 9144300 39.5675 µM -0.251059144604775 0.399441524705304 no 2047 0.400884191159017 2921 4901274 SGTC_889 0919-1524 82.7 µM -0.251115733081416 0.399419625529634 no 2048 0.400862316160001 2917 3905452 SGTC_95 0471-0001 561.058 µM -0.251490923406933 0.399274438626285 no 2049 0.400717289409468 2863 4015405 SGTC_1824 st053723 68.6 µM -0.251568871926392 0.399244276738058 no 2050 0.400687160763162 2898 675225 SGTC_2443 5493264 126.67 µM -0.25191378046277 0.39911082289029 no 2051 0.400553853877073 3024 5340055 SGTC_1921 5740136 50 µM -0.252175295631483 0.399009643906995 no 2052 0.400452786183279 3056 1774243 SGTC_697 0508-1955 564 µM -0.252294862684864 0.398963386238784 no 2053 0.400406579357615 2994 6243113 SGTC_31 0508-1974 57.237 µM -0.254326715590024 0.398177527795382 no 2054 0.39962158106344 2963 6810525 SGTC_2393 9031399 185.94 µM -0.254329435129885 0.398176476236648 no 2055 0.399620530651114 3022 1526623 YDL150W RPC53 SGTC_1795 st049545 62.3 µM -0.254820304594556 0.397986684898099 no 2056 0.399430946022921 2920 5291882 SGTC_22 0964-0034 14.468 µM -0.254953853527753 0.397935053286572 no 2057 0.399379370576945 2880 138402 SGTC_1849 st056239 19.2 µM -0.255149401524616 0.397859455322028 no 2058 0.399303854795777 2854 5393181 SGTC_3253 9135987 49.47 µM -0.255158814385167 0.397855816449751 no 2059 0.399300219877766 2983 4182430 SGTC_3315 9136395 68.55 µM -0.255740329027969 0.397631028757637 no 2060 0.399075676172942 2985 16876844 SGTC_1794 st048918 76.9 µM -0.256561234314781 0.397313761160749 no 2061 0.398758751991921 2900 672303 SGTC_2926 9010726 65.15 µM -0.256912279204569 0.397178108292475 no 2062 0.398623245616907 2973 2994293 SGTC_1605 st000082 49.1 µM -0.257189684659709 0.397070920412282 no 2063 0.39851617334626 2975 1114022 SGTC_2749 bexarotene 57.39 µM -0.257328787960798 0.397017174619035 no 2064 0.3984624854737 2964 82146 An retinoic acid receptor inhibitor. SGTC_1680 diphenhydramine 100 µM -0.258377574620908 0.396612014549969 no 2065 0.398057761007327 2907 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1 SGTC_3355 9151058 44.0485 µM -0.25861398860462 0.396520700119704 no 2066 0.397966544501412 2847 17015728 SGTC_1385 3091-4834 14.1 µM -0.258682451300924 0.396494257599153 no 2067 0.397940130320196 2971 4072814 SGTC_145 3737-0113 38.366 µM -0.258764039863015 0.396462746063944 no 2068 0.397908652546831 3001 6849351 SGTC_932 2857-0803 154 µM -0.259058702825732 0.396348945520392 no 2069 0.397794973838859 3088 674898 SGTC_2629 bisabolol 100 µM -0.259525477041258 0.396168692690951 no 2070 0.397614913695186 3011 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer. SGTC_2466 5983409 37.09 µM -0.259900576468595 0.396023857728518 no 2071 0.397470233296374 2896 2879657 SGTC_1449 4112-4002 201 µM -0.260258856664492 0.395885530479291 no 2072 0.397332053448422 2896 2059539 SGTC_2964 9083345 53.42 µM -0.260509022111864 0.395788952677959 no 2073 0.397235578434195 2925 17741579 SGTC_1531 st059297 52.4 µM -0.26054077177186 0.395776695997561 no 2074 0.397223334791088 2977 7566702 SGTC_2565 isoliquiritigenin 100 µM -0.261295089218565 0.395485528637065 no 2075 0.396932476650847 3009 638278 Binds to benzodiazepine receptor 65X better than valium. SGTC_1468 k284-1086 134 µM -0.26159330812292 0.395370431892902 no 2076 0.396817501879576 2905 15996457 SGTC_2489 cantharidin 73.42 µM -0.26167228233437 0.39533995354697 no 2077 0.39678705580815 2837 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_2898 9056270 58.44 µM -0.26191017025036 0.395248149849418 no 2078 0.396695349262024 2848 19154699 SGTC_3336 9143619 71.43 µM -0.262359475886284 0.395074773472534 no 2079 0.396522156105041 2937 45595730 SGTC_1945 st075991 56.6 µM -0.264088276620544 0.394407864327089 no 2080 0.395855948609893 2932 1084980 SGTC_2723 salbutamol 83.58 µM -0.264831125683073 0.394121394796937 no 2081 0.395569778948459 2970 9884233 β2-adrenoceptor agonist SGTC_3170 9103054 49.47 µM -0.266035500449459 0.393657065981102 no 2082 0.39510593423174 2932 16432970 SGTC_1192 1488-0095 21.4 µM -0.26638076891483 0.393523980700684 no 2083 0.394972987258456 2953 915875 SGTC_2085 5307070 144.047 µM -0.266422444855184 0.393507917363323 no 2084 0.394956940601299 2850 2840351 SGTC_1703 st026983 48.3 µM -0.267556339893272 0.393070944947154 no 2085 0.394520420829609 3030 1104023 SGTC_9 0092-0002 10.449 µM -0.268907109099945 0.392550570944582 no 2086 0.394000583071573 2917 759368 SGTC_1054 3429-0080 167 µM -0.269144388513132 0.392459180581518 no 2087 0.393909286572353 3061 1162877 SGTC_3015 9080845 49.47 µM -0.270675937971696 0.391869433004743 no 2088 0.39332014244741 3016 5296973 SGTC_2991 9074669 71.4286 µM -0.272342782706008 0.39122787008833 no 2089 0.392679231556949 3081 17333109 SGTC_1460 k062-0059 9.15 µM -0.272743294092211 0.39107375862327 no 2090 0.392525276025669 2795 1373085 SGTC_2899 9053889 58.44 µM -0.272823507326791 0.391042895690159 no 2091 0.392494444288233 2977 6470052 SGTC_144 4161-2749 112.381 µM -0.273252032385464 0.390878027542209 no 2092 0.392329742603845 2900 797501 YMR168C CEP3 SGTC_130 0136-0219 337.655 µM -0.275593893744735 0.38997738109453 no 2093 0.391430000096904 2844 234244 SGTC_3234 9132280 49.47 µM -0.276509953799771 0.389625237830192 no 2094 0.391078207767935 2975 17612295 SGTC_1530 rhein 70.4 µM -0.277357542386937 0.389299496411817 no 2095 0.390752789722254 2877 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death. SGTC_2048 5246248 200 µM -0.277664124270407 0.389181691388731 no 2096 0.390635101351168 3012 677046 SGTC_1426 4048-4480 71.7 µM -0.278169964777388 0.388987342903995 no 2097 0.390440944968389 3008 14224343 SGTC_1312 1218-2183 165 µM -0.278969014450443 0.38868039742024 no 2098 0.390134302008141 2895 6744073 SGTC_1463 k081-0032 34.1 µM -0.279483670538431 0.388482735148222 no 2099 0.389936833983886 2976 977755 SGTC_798 1287-0182 476 µM -0.279825942815191 0.388351295743722 no 2100 0.389805523502217 3087 1649755 SGTC_3205 9113483 49.47 µM -0.279948426123764 0.388304262807312 no 2101 0.389758536650477 3085 17018033 SGTC_299 1273-0059 1.44 µM -0.280021453738416 0.388276221372621 no 2102 0.389730522679875 2995 2848077 SGTC_272 doxorubicin 8.13 µM -0.280249376984052 0.388188706241791 no 2103 0.389643093204762 2887 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_2607 solasodine 47.35 µM -0.280679717054671 0.388023485100186 no 2104 0.389478033536123 2913 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity. SGTC_3271 9137798 49.47 µM -0.281094445150408 0.387864277065585 no 2105 0.389318980803567 3021 6498326 SGTC_2647 atorvastatin 60.16 µM -0.28267356264298 0.387258249743567 no 2106 0.388713541996361 2972 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7 SGTC_1279 0874-0590 65.2 µM -0.28370011834824 0.386864429568696 no 2107 0.388320102013361 2964 3523074 SGTC_1286 0929-0070 131 µM -0.286204929853806 0.385903991861777 no 2108 0.387360584066641 3015 1420408 SGTC_2366 9070441 60.58 µM -0.28665318052501 0.385732189479058 no 2109 0.387188945095271 2920 6837235 SGTC_969 1313-0238 134 µM -0.287226058117253 0.385512653592147 no 2110 0.386969617528835 2917 5212874 SGTC_223 busulfan 5 mM -0.288420362425842 0.385055095017199 no 2111 0.386512491357712 2999 2478 A DNA alkylator. SGTC_397 arbidol 50 µM -0.288461434487159 0.385039362444528 no 2112 0.3864967736099 3064 131410 A RNA synthesis inhibitor. SGTC_729 4092-0585 94.1 µM -0.288465027530295 0.385037986145391 no 2113 0.386495398607519 2899 2169061 SGTC_1354 1498-1681 81 µM -0.289649476298674 0.384584367360004 no 2114 0.386042206036491 3005 5754243 SGTC_1040 k898-0338 155 µM -0.290394466035081 0.384299132963662 no 2115 0.385757238429141 3121 20969351 SGTC_1899 st063254 59.6 µM -0.291300180259455 0.383952446327151 no 2116 0.385410874796885 2876 3093813 SGTC_2288 7946289 167.31 µM -0.291889780377131 0.383726810797731 no 2117 0.38518544874452 3131 1246052 SGTC_1666 st014829 29 µM -0.292724258581751 0.383407529656203 no 2118 0.384866463014499 2874 3858230 SGTC_25 0118-0223 35.662 µM -0.29405520209154 0.382898458969092 no 2119 0.384357860901271 3065 5333628 SGTC_2754 granisetron 64.02 µM -0.294462179356767 0.382742835143823 no 2120 0.384202379721101 3066 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients. SGTC_2415 st077333 57.7 µM -0.294701310280933 0.382651402821311 no 2121 0.384111031074769 3165 2766255 SGTC_1789 tunicamycin 25 nM -0.29573026212975 0.382258055117331 no 2122 0.383718042245624 3049 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_724 3910-0327 137 µM -0.296735485120269 0.381873895779514 no 2123 0.383334231666376 2996 2885483 SGTC_538 2922-0838 53.3 µM -0.29706356005214 0.381748542732595 no 2124 0.383208992050097 3129 777039 SGTC_139 0099-0334 718.624 µM -0.298534518269911 0.381186661854792 no 2125 0.382647617366937 2910 97690 SGTC_1221 2958-7315 257 µM -0.29892505984485 0.381037523667988 no 2126 0.382498612920539 3004 4562705 SGTC_2011 4012611 177 µM -0.298980943756499 0.38101618442622 no 2127 0.382477292793651 2916 2049887 SGTC_948 3448-0295 75.3 µM -0.29933399298029 0.380881381135399 no 2128 0.382342610131848 2911 678569 SGTC_3204 9114183 49.47 µM -0.299998013054989 0.380627880339502 no 2129 0.38208933560789 2881 17027248 SGTC_1121 fusaric acid 630.51 nM -0.300198311552879 0.380551423085281 no 2130 0.382012946451418 2947 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler. SGTC_1669 st015249 58.4 µM -0.301867114583008 0.379914594955422 no 2131 0.381376682869729 3028 722793 SGTC_726 3448-4391 34.2 µM -0.302044749779819 0.379846827129603 no 2132 0.381308974841092 3122 1356692 SGTC_2788 5282734 71.43 µM -0.302590592557963 0.379638611211828 no 2133 0.381100942313417 3101 743706 SGTC_1812 st052057 4.327 µM -0.303013085283409 0.379477472073374 no 2134 0.380939944753033 2902 3645418 SGTC_1409 3909-8004 61.9 µM -0.303169226135389 0.379417925095839 no 2135 0.380880450016992 2970 2119279 SGTC_249 wiskostatin 11.211 µM -0.30526371657836 0.378619432483835 no 2136 0.380082653919668 2983 2775510 A n-wasp and actin depolymerizer. SGTC_3019 9081971 49.47 µM -0.305934086628367 0.378363973348518 no 2137 0.37982741603819 3106 16451803 SGTC_513 4245-1575 41.7 µM -0.307533647030528 0.377754640876601 no 2138 0.379218608213252 3039 719745 SGTC_1830 st055982 50.3 µM -0.307893423815578 0.377617630256195 no 2139 0.379081714959888 3069 455313 An antimicrobial agent. SGTC_2804 7954240 19.48 µM -0.30800875297757 0.377573713726676 no 2140 0.379037836003672 3099 828705 SGTC_1497 4476-2978 41.3 µM -0.309611485653012 0.376963568522892 no 2141 0.378428210464407 3033 1528379 SGTC_536 3852-0578 10.6 µM -0.311761370555148 0.376145610121822 no 2142 0.377610941827061 3114 2869208 SGTC_1660 st012960 28.1 µM -0.311856811911938 0.376109310781054 no 2143 0.377574672913247 3042 24207266 SGTC_3254 9136651 49.47 µM -0.312231803591198 0.375966700302355 no 2144 0.37743218182294 2988 16454030 SGTC_1664 st014217 9.02 µM -0.312819962776788 0.375743055694688 no 2145 0.377208723957444 3000 3982782 SGTC_2042 p-Dimethylaminoacetophenone 200 µM -0.313259825283654 0.375575827437039 no 2146 0.377041634947253 3022 75037 A free radical scavenger. SGTC_389 tpck 16.7 µM -0.313476163023184 0.375493588074024 no 2147 0.376959463941595 3027 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.  SGTC_2441 5730946 39.09 µM -0.31736573382846 0.374015961989288 no 2148 0.375483052369042 3089 1774275 SGTC_3201 9113999 49.47 µM -0.318810938486522 0.373467406896972 no 2149 0.374934941536222 3152 16649224 SGTC_2474 5321570 43.32 µM -0.320234873124072 0.372927175893296 no 2150 0.374395144539117 3087 2841384 SGTC_2238 6671620 73.2395 µM -0.320752835725793 0.372730726348058 no 2151 0.374198851950809 2894 729941 SGTC_232 clozapine 119 µM -0.321017405817177 0.37263039466219 no 2152 0.374098600248589 2947 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_927 2425-1185 123 µM -0.321254245193472 0.372540586496707 no 2153 0.374008863575265 2938 730375 SGTC_1560 lithocholic acid 53.1 µM -0.321720734954155 0.37236371646138 no 2154 0.373832134055592 3038 9903 A bile acid which acts as a detergent. SGTC_2533 agelasine 13.65 µM -0.322357432666976 0.372122355367848 no 2155 0.373590964108245 3173 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase. SGTC_398 bronopol 33.3 µM -0.323202120609026 0.371802226315525 no 2156 0.373271087504586 2943 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them. SGTC_2664 lyso-paf C-16 73.48 µM -0.323368864822545 0.371739042240833 no 2157 0.373207953110514 2975 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_3096 9117468 49.47 µM -0.324454407239349 0.371327784199728 no 2158 0.372797017263121 3095 41316311 SGTC_1444 4112-3581 28 µM -0.324725556450095 0.37122508215271 no 2159 0.372694395359205 2988 2877249 SGTC_3143 9086658 49.47 µM -0.324761939544741 0.37121130217843 no 2160 0.372680626128416 3030 25236626 SGTC_1179 1021-1431 9.29 µM -0.325676490978849 0.370864973189978 no 2161 0.372334566403417 3062 2840958 SGTC_1695 st026914 34.495 µM -0.326003893636954 0.370741015378302 no 2162 0.372210704615414 2952 3289191 SGTC_633 0437-0093 97.7 µM -0.327610044436672 0.37013310571223 no 2163 0.371603263184173 2987 2831118 SGTC_154 3389-1638 511.116 µM -0.327685036852787 0.370104729854754 no 2164 0.37157490907395 3055 5238686 SGTC_2318 6029776 164 µM -0.328607892930276 0.369755594707097 no 2165 0.371226040707619 3179 818325 SGTC_2643 anethole 100 µM -0.331051851593705 0.368831514855187 no 2166 0.370302659850182 3044 637563 An anti-fungal, anti-helmenthic and channel blocker. SGTC_2801 7907800 81.82 µM -0.331645273536115 0.36860725152292 no 2167 0.370078564595992 3093 6620925 SGTC_2325 6158266 200 µM -0.333439513599108 0.367929452888692 no 2168 0.369401270239534 3060 3623240 SGTC_994 3910-0338 138 µM -0.333754230542398 0.367810606584629 no 2169 0.369282511781168 3174 3479481 SGTC_449 xestospongin c 11.1929 µM -0.334008596751559 0.367714559726144 no 2170 0.369186535790572 3098 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1 SGTC_1298 1079-1278 263 µM -0.33403140610862 0.36770594748037 no 2171 0.369177929893836 3015 2840950 SGTC_254 nsc-64875 3.808 µM -0.334071913196281 0.367690653175771 no 2172 0.369162646862135 3139 56993 SGTC_789 1309-1135 70.6 µM -0.334599008097457 0.36749165652411 no 2173 0.36896379662447 2972 3092424 SGTC_3190 9110366 49.47 µM -0.334784950257937 0.367421465379529 no 2174 0.368893657008798 3102 17123768 SGTC_810 3825-7150 143 µM -0.335680415704451 0.367083498973263 no 2175 0.368555937871154 3170 22330411 YGL099W LSG1 SGTC_1198 1612-1005 86.7 µM -0.33616655442031 0.366900063695544 no 2176 0.368372636218503 3178 6998509 SGTC_1783 st039459 87.517 µM -0.336328875904686 0.366838821509027 no 2177 0.36831143855302 3194 729761 SGTC_1415 3966-0071 78.1 µM -0.336945371894311 0.366606254956667 no 2178 0.368079040651886 3047 2893185 SGTC_1403 3909-7815 62.9 µM -0.337495711803692 0.366398686445143 no 2179 0.367871622105912 2968 6615483 SGTC_3242 9133940 49.47 µM -0.338189867437678 0.36613693152565 no 2180 0.367610055550379 3144 17248444 SGTC_1037 k284-1091 78.7 µM -0.338212410059224 0.366128432109311 no 2181 0.367601562236344 2966 3334711 SGTC_1588 farnesol 29.9 µM -0.339861417092832 0.365506872817578 no 2182 0.36698044680772 2992 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_1214 0358-0031 63.7 µM -0.339880130005219 0.365499821392758 no 2183 0.366973400391267 3241 4301366 SGTC_2398 5228213 48.84 µM -0.345217333102055 0.363490513204023 no 2184 0.364965494460431 3221 80771 YMR134W ERG29 SGTC_3108 9121785 49.47 µM -0.345860527366317 0.363248620578347 no 2185 0.364723767294707 2946 17140271 SGTC_2475 5812728 15.03 µM -0.347695691423552 0.36255875175142 no 2186 0.364034366383552 2985 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2 SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM -0.349042114872374 0.362052892177375 no 2187 0.363528846176143 3104 17037758 SGTC_207 4185-0010 4.486 µM -0.349050871008853 0.362049603230395 no 2188 0.363525559425251 3107 3761753 SGTC_136 0097-0015 404.482 µM -0.349531050424547 0.361869255650366 no 2189 0.363345332061187 3091 4861337 SGTC_826 1683-5028 118 µM -0.35031561317741 0.361574652649826 no 2190 0.363050924569129 3099 722377 SGTC_1252 0493-0875 34.8 µM -0.350321263878016 0.361572531111369 no 2191 0.363048804434691 2994 3960963 SGTC_1518 st038567 90.8 µM -0.350632443737343 0.361455706145759 no 2192 0.3629320566967 3078 77966 SGTC_1877 wortmannin 25 µM -0.35117102472879 0.361253539442595 no 2193 0.362730023236167 3163 312145 A covalent inhibitor of PI 3-kinase. SGTC_3116 9124943 49.47 µM -0.351705627323837 0.361052904419589 no 2194 0.362529519944133 3047 41905195 YPL160W CDC60 SGTC_1033 k072-0102 21.3 µM -0.351986495210829 0.360947510712831 no 2195 0.362424195235213 3187 5965931 SGTC_1503 4585-0012 61.3 µM -0.352141602343334 0.360889312372478 no 2196 0.362366034936206 3191 2922052 SGTC_2418 pentamidine 31.67 µM -0.352621941298353 0.36070910299336 no 2197 0.362185943083634 3120 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_2260 7964312 200 µM -0.352812996933913 0.360637433001181 no 2198 0.362114319719874 3180 231951 SGTC_864 0469-0573 172 µM -0.352978738597793 0.360575262910289 no 2199 0.362052190024966 3024 689425 SGTC_2360 9040895 200 µM -0.353491685018156 0.360382878850405 no 2200 0.361859930664593 3074 4914414 SGTC_2770 toltrazuril 17.5 µM -0.355009065774314 0.359813981906102 no 2201 0.361291399767949 3094 68591 Kills coccidiodes. SGTC_1636 st007707 68.9 µM -0.356975256945391 0.359077278678941 no 2202 0.360555164554451 3238 403051 SGTC_1604 st002052 72.4 µM -0.358209862874984 0.358614957297068 no 2203 0.360093133408288 3155 6254834 YHR062C RPP1 SGTC_722 3534-0461 190 µM -0.359394954786922 0.358171372164616 no 2204 0.359649824230488 3064 658262 SGTC_660 4031-1742 102 µM -0.36150483212989 0.357382109729084 no 2205 0.358861046685126 3049 6738706 SGTC_1031 k035-0009 16 µM -0.36191418249078 0.357229050554084 no 2206 0.3587080806362 3209 5180959 SGTC_512 prima-1 270 µM -0.362858715703184 0.35687597017186 no 2207 0.358355213953713 3183 322968 A re-activator of the apoptotic function of mutant p53. SGTC_1434 4073-0095 163 µM -0.362912184960454 0.356855986241382 no 2208 0.358335242071401 3115 24133745 SGTC_3044 9093193 49.47 µM -0.364035484267595 0.356436248307335 no 2209 0.357915756030084 3144 25236277 SGTC_527 4476-4215 268 µM -0.364136739196887 0.356398421391176 no 2210 0.357877951705343 3056 4418754 SGTC_1776 st049249 45.9 µM -0.364426909033427 0.356290027284549 no 2211 0.357769622234978 3091 1822314 SGTC_1992 st073643 23.3 µM -0.365990563826514 0.355706117815662 no 2212 0.357186058401016 3027 3161292 SGTC_1353 1498-1206 8.11 µM -0.36649173241799 0.355519039945145 no 2213 0.356999090355463 3086 6756808 SGTC_2181 6316240 54.2555 µM -0.366533788815913 0.355503342575927 no 2214 0.356983402181306 3128 12779990 SGTC_1097 itavastatin 7.23 µM -0.36798196583216 0.354962966438572 no 2215 0.3564433406763 3085 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49 SGTC_2814 7977482 42.97 µM -0.368126068299441 0.354909211644351 no 2216 0.356389616978114 3201 6456762 SGTC_1978 st071761 42 µM -0.370913314217764 0.353870049801565 no 2217 0.355351049053731 3053 5147680 SGTC_444 curcumin 90.4 µM -0.371455947875738 0.353667867319218 no 2218 0.355148980529192 3179 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. SGTC_182 3448-4371 550.524 µM -0.374312512626868 0.352604207804236 no 2219 0.354085911945357 3113 3491403 SGTC_216 k038-0035 28.382 µM -0.375545088578009 0.352145605625128 no 2220 0.353627560087714 3147 4444231 YPR107C YTH1 SGTC_2608 thymoquinone 42.66 µM -0.376066083241886 0.351951824724473 no 2221 0.353433884150133 3150 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC). SGTC_2271 7849410 118.62 µM -0.377051220725483 0.351585513744554 no 2222 0.353067770270484 3213 972430 SGTC_2381 9035592 200 µM -0.377248159502265 0.351512301050962 no 2223 0.352994596763888 3115 4749657 SGTC_2519 cryptotanshinone 88.04 µM -0.377790707459808 0.351310635405827 no 2224 0.352793038704166 3213 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE) SGTC_840 0245-0196 390 µM -0.37802873298658 0.351222174273576 no 2225 0.352704624599699 3210 3827528 SGTC_3277 9138724 49.47 µM -0.378207127147287 0.351155880158132 no 2226 0.352638365661678 3100 15943418 SGTC_2019 4016004 108 µM -0.381042339720864 0.350102879150452 no 2227 0.351585915821929 3141 45595336 SGTC_1310 1188-0297 994 nM -0.382327066558079 0.349626108815403 no 2228 0.351109390340253 3097 1588352 SGTC_716 1683-5115 658 µM -0.384445952739893 0.348840294850004 no 2229 0.350323973531843 3111 723597 SGTC_1565 sinapyl alcohol 95.1 µM -0.384504451041281 0.348818609240106 no 2230 0.350302298768721 3174 5280507 A phenol propionate derived from cinnamic acid. SGTC_2906 7926292 26.41 µM -0.384606027340505 0.348780955576487 no 2231 0.350264663924359 3196 2966319 SGTC_2421 5690543 90.72 µM -0.385002967670805 0.348633826701327 no 2232 0.350117608407906 3179 3397993 SGTC_2703 st077852 53.4 µM -0.38518039417879 0.348568069611603 no 2233 0.350051884014061 3183 6281836 SGTC_2827 7993847 71.43 µM -0.385528674833569 0.348439004486852 no 2234 0.349922882900336 3160 2985692 SGTC_2424 5537928 59.2 µM -0.386628731145837 0.34803146318116 no 2235 0.349515542299776 3091 5382802 SGTC_2077 5212015 200 µM -0.387314467284551 0.34777750511508 no 2236 0.349261708211678 3053 780900 SGTC_2154 5570129 200 µM -0.389086348325367 0.347121616515782 no 2237 0.348606135925466 3149 673366 SGTC_533 1222-0222 6.71 µM -0.391594853014495 0.346193838474958 no 2238 0.34767879574682 3255 3982874 SGTC_1249 0481-0015 10.2 µM -0.394069544421163 0.345279469958278 no 2239 0.346764847757033 3048 4227577 SGTC_2918 7977171 22.06 µM -0.394821149359738 0.345001939434118 no 2240 0.346487442705127 3107 2236483 SGTC_1137 ixabepilone 100 µM -0.396818636808042 0.344264771618316 no 2241 0.345750603254554 3079 154225 A novel microtubule stabilizer. SGTC_493 zm226600 134 µM -0.397967030187462 0.343841227375827 no 2242 0.345327244443888 3260 5240098 A potassium channel opener. YCR052W RSC6 SGTC_3026 9090633 49.47 µM -0.401058987435446 0.342701843436899 no 2243 0.344188347599086 3107 25236842 SGTC_2792 7535235 81.82 µM -0.401762196086468 0.342442910726242 no 2244 0.343929523192072 3150 1281891 SGTC_2448 5185112 27.17 µM -0.401763545368108 0.342442413970214 no 2245 0.343929026642969 3226 5718189 SGTC_590 k048-0076 22.4 µM -0.401809985907404 0.342425316432549 no 2246 0.343911936225343 3226 6832814 SGTC_1922 5578187 25 µM -0.401867235898411 0.342404239734172 no 2247 0.343890868298748 3296 1350412 SGTC_1910 st062352 60.4 µM -0.4037736318255 0.34170267690482 no 2248 0.343189594090148 3032 2245730 SGTC_748 act1.228 77.9 µM -0.404081204954968 0.341589539648471 no 2249 0.34307650276695 3105 4421505 YNR035C ARC35 SGTC_2837 9008476 45.46 µM -0.405175889520155 0.341186987971439 no 2250 0.342674113145491 3272 2992805 SGTC_1432 4049-0298 68.4 µM -0.4079301670676 0.340174949146411 no 2251 0.341662472215614 3219 741646 SGTC_1227 3909-8010 46.6 µM -0.409113246379148 0.339740588172737 no 2252 0.341228277828572 3124 15982272 SGTC_3148 9097893 49.47 µM -0.409885693326766 0.33945710332711 no 2253 0.34094490034632 3091 17174100 SGTC_2491 paeonol 100 µM -0.410227287523186 0.339331768617291 no 2254 0.340819612761613 3072 11092 Increases levels of cortical cytochrome oxidase. SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM -0.411014390462868 0.339043039469966 no 2255 0.34053099137491 3105 6312947 SGTC_19 0279-0214 38.434 µM -0.411610815431285 0.33882431872742 no 2256 0.340312351521088 3152 3566274 YBR002C RER2 SGTC_1810 st050138 53 µM -0.412281369537057 0.3385784782562 no 2257 0.340066601202894 3245 3444541 SGTC_141 0443-0274 32.331 µM -0.413314957868565 0.338199675854622 no 2258 0.339687936126221 3295 1627241 SGTC_3306 9127676 59.7925 µM -0.414400872602213 0.337801872581275 no 2259 0.339290274991488 3208 41905287 SGTC_1556 plumbagin 1.48 µM -0.414492382591147 0.337768357984434 no 2260 0.339256772272547 3201 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_3316 9136639 10.545 µM -0.415554517561605 0.337379456090916 no 2261 0.338868007104436 3234 4903665 SGTC_875 0709-0210 25.7 µM -0.416225608576559 0.337133824871398 no 2262 0.338622461191569 3265 6251364 SGTC_1371 2421-0008 32.7 µM -0.416263429172019 0.337119983927733 no 2263 0.338608625030605 3130 2827552 SGTC_1398 3558-0053 112 µM -0.417064796595768 0.336826764849322 no 2264 0.338315506666236 3057 4532369 SGTC_1326 1431-2094 10.8 µM -0.419912311490995 0.335785666747256 no 2265 0.33727475677718 3073 616278 SGTC_809 3998-0021 90 µM -0.420593631256948 0.335536751438349 no 2266 0.337025922550022 3273 715485 SGTC_2072 5231554 129 µM -0.421104169088294 0.335350277377991 no 2267 0.336839508681619 3284 789545 SGTC_1631 benzylvanillin 81.9 µM -0.421555488876008 0.33518546649406 no 2268 0.336674750604398 3267 75506 SGTC_1885 st057546 99.9 µM -0.421677214585474 0.335141020689944 no 2269 0.336630318977972 3306 702008 SGTC_1649 st011737 51.3 µM -0.421941979484403 0.335044354844788 no 2270 0.336533683875515 3193 1761035 SGTC_1848 st056003 16.4 µM -0.423121009089657 0.334614023061868 no 2271 0.336103487411207 3253 146492 SGTC_202 3594-0513 34.79 µM -0.423202764513516 0.334584191349439 no 2272 0.336073664986132 3176 708429 SGTC_2782 7736369 71.43 µM -0.423276236792817 0.334557382962072 no 2273 0.336046864934559 3159 2950836 YOL077C BRX1 SGTC_653 0203-0016 55.2 µM -0.424606856415666 0.334072015777586 no 2274 0.335561646978765 3193 295302 SGTC_1977 st070720 65.3 µM -0.425802489228662 0.333636123993 no 2275 0.335125886476396 3246 682188 SGTC_251 melphalan 456.522 µM -0.426182894557315 0.333497486685995 no 2276 0.334987290381128 3217 460612 A DNA alkylator. SGTC_2341 7987486 176.74 µM -0.428478965800474 0.332661175431661 no 2277 0.334151222162062 3297 1258686 SGTC_3098 9119039 49.47 µM -0.429420683615854 0.332318408502505 no 2278 0.333808552077658 3233 17161528 SGTC_8 0354-0001 70 µM -0.430350794203841 0.331980003989807 no 2279 0.333470241597551 3181 4993152 SGTC_2936 9038235 15.59 µM -0.430689095552966 0.33185695290926 no 2280 0.333347224319782 3148 4749415 SGTC_2321 7390090 138.78 µM -0.431237503976974 0.331657517661483 no 2281 0.333147843416437 3180 649046 SGTC_1280 0880-0253 10.1 µM -0.432966274733657 0.331029142064263 no 2282 0.332519635471738 3171 6836607 SGTC_1381 2324-0066 62.1 µM -0.434418519154445 0.330501646084475 no 2283 0.331992276033019 3255 10885928 SGTC_1761 st044296 37 µM -0.435670585144932 0.330047130637897 no 2284 0.331537875158942 3133 1826700 SGTC_345 1362-0200 395 µM -0.436132678974689 0.329879448169972 no 2285 0.331370234239386 3182 1419823 SGTC_2263 7948595 193.29 µM -0.437567056150378 0.329359165865654 no 2286 0.330850078375918 3145 2971371 SGTC_40 0327-0103 19.753 µM -0.437792549205809 0.329277404248275 no 2287 0.330768336287903 3155 409036 SGTC_372 0155-0182 15.9 µM -0.438935132200426 0.328863240175348 no 2288 0.330354269718087 3148 771486 SGTC_1062 mesoridazine 14.2 µM -0.439668644291138 0.32859746700861 no 2289 0.330088557866948 3213 4078 A neuroleptic. SGTC_805 3852-0218 479 µM -0.439676987980401 0.328594444341116 no 2290 0.330085535891165 3168 6615355 SGTC_402 epigallocatechin gallate 10 µM -0.441691625727243 0.327864930414938 no 2291 0.329356185194771 3177 65064 An antioxidant. SGTC_2115 tiliquinol 12.7705 µM -0.442042699924072 0.327737871157239 no 2292 0.329229153609816 3228 71208 A bioactive hydroxyquinoline. SGTC_2476 5806916 10.51 µM -0.443598890033265 0.327174901831832 no 2293 0.328666304189515 3152 2870194 SGTC_2 0422-0095 29 µM -0.44503555613304 0.32665552044772 no 2294 0.328147029505085 3212 6790840 SGTC_2816 7982706 58.44 µM -0.445039187670495 0.326654208004761 no 2295 0.328145717326976 3263 2981853 SGTC_247 mechlorethamine 29.705 µM -0.44618889400299 0.326238810370467 no 2296 0.327730402309031 3187 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links. SGTC_1797 st048695 56.8 µM -0.446972898927703 0.325955666961537 no 2297 0.327447313828849 3280 592262 YIL048W NEO1 SGTC_386 1509-0011 3.07 µM -0.448067767294395 0.325560423123929 no 2298 0.327052144788133 3205 3107280 SGTC_2578 7,8-dihydroxyflavone 64.44 µM -0.449151603293029 0.325169355020304 no 2299 0.32666114853365 3118 1880 Intensifies effect of antibiotics on Staphylococcus aureus. SGTC_594 1487-1584 10.8 µM -0.449840045309098 0.324921052324409 no 2300 0.326412890342026 3184 5013332 SGTC_2401 5128683 200 µM -0.450013695989882 0.324858433425341 no 2301 0.326350282529506 3182 708373 SGTC_2384 9036245 200 µM -0.450240363644815 0.324776703909205 no 2302 0.326268567400433 3214 6462766 SGTC_563 tetrahydrosecaminediol 614 µM -0.450414381723986 0.324713963964393 no 2303 0.326205838436129 3329 334274 A psychoactive constituent of the cannabis plant. SGTC_101 0490-5701 117.494 µM -0.45077303236445 0.324584672849519 no 2304 0.326076569774565 3259 4661669 SGTC_167 3672-0051 66.205 µM -0.451518497846576 0.324316005255309 no 2305 0.325807948085564 3162 3237971 SGTC_473 2-arachidonoylglycerol 10 µM -0.451799695167006 0.324214684792282 no 2306 0.325706644670275 3154 5282280 An endocannabinoid. SGTC_859 0439-0102 54.6 µM -0.452980462829328 0.323789375074508 no 2307 0.325281404933665 3320 610143 SGTC_1009 4106-0057 9.87 µM -0.454362831823599 0.323291741292983 no 2308 0.324783849790668 3343 2928005 SGTC_1764 st044502 93.5 µM -0.456313075705238 0.322590217876786 no 2309 0.324082431281428 3316 8407 SGTC_1837 st055472 66.5 µM -0.4576352089207 0.322114991287828 no 2310 0.323607271794677 3374 676091 SGTC_2620 irigenin 100 µM -0.457747307282849 0.322074712092429 no 2311 0.323566998139324 3371 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro. SGTC_2351 9026858 72.31 µM -0.458029035416875 0.321973490736362 no 2312 0.323465790603612 3148 1409300 SGTC_1654 st012436 41.8 µM -0.458985791453937 0.321629839007083 no 2313 0.323122184708509 3291 4323132 SGTC_1217 1183-1422 255 µM -0.461428858959685 0.320753020278414 no 2314 0.322245475306478 3333 2849664 SGTC_2490 carminic acid 95.39 µM -0.461569164416269 0.320702694836219 no 2315 0.322195155806481 3309 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_1223 0764-0573 147 µM -0.461929666124079 0.320573403446067 no 2316 0.322065879516692 3247 1609797 SGTC_648 0375-0473 33.3 µM -0.462003312611412 0.320546993330983 no 2317 0.322039472456769 3218 1713139 SGTC_421 streptovitacin 30 mM -0.46362257473232 0.319966545072262 no 2318 0.321459088827845 3354 91467 include heat shock SGTC_2715 st079500 56.4 µM -0.46536713219684 0.319341675741583 no 2319 0.320834283682689 3189 28246688 SGTC_2955 9076254 12.21 µM -0.465637051256403 0.319245041315853 no 2320 0.32073765868332 3299 16459619 SGTC_1276 0871-0068 94.2 µM -0.46848847189462 0.318224947846886 no 2321 0.319717656538627 3267 3414906 SGTC_3311 9131146 2.8755 µM -0.469899949279853 0.317720501955985 no 2322 0.319213250273884 3246 4900406 YPR165W RHO1 SGTC_1710 st031758 61.5 µM -0.471230019072775 0.317245459636593 no 2323 0.318738241914321 3382 5394341 SGTC_2111 5486399 200 µM -0.472310362413646 0.316859830037207 no 2324 0.318352637484668 3266 689674 SGTC_2128 5255449 168.493 µM -0.472836747475356 0.316672008414094 no 2325 0.318164827341309 3216 736008 SGTC_884 0851-0618 334 µM -0.476070652302149 0.315519143923443 no 2326 0.317012022109273 3327 9642473 SGTC_1658 st012944 20 µM -0.477094604762873 0.315154485280992 no 2327 0.316647378190804 3305 24207260 SGTC_887 0885-0007 9.62 µM -0.477650000988444 0.314956768153039 no 2328 0.316449668236775 3335 5719458 SGTC_1321 1326-2144 215 µM -0.480040279620474 0.314106451500873 no 2329 0.315599375939351 3321 3513030 SGTC_2851 9015922 71.43 µM -0.480611348698271 0.313903445377708 no 2330 0.315396374069176 3369 2996893 SGTC_2603 homopterocarpin 100 µM -0.482821695955421 0.313118232756353 no 2331 0.314611172219068 3321 101795 A weak amylase inhibitor. SGTC_913 3487-1245 167 µM -0.482848573603685 0.313108689836538 no 2332 0.314601629374586 3190 4016153 SGTC_3174 9107204 49.47 µM -0.484436294008629 0.312545191359027 no 2333 0.314038132975425 3362 3938802 SGTC_3347 9188721 44.724 µM -0.484950046273598 0.312362949061221 no 2334 0.313855890351407 3311 44118411 YKL104C | YBL026W GFA1 | LSM2 SGTC_767 0929-0023 86 µM -0.485476771976373 0.312176152362531 no 2335 0.313669092811376 3367 1204563 SGTC_3007 9078383 71.4286 µM -0.48602882850787 0.311980424213909 no 2336 0.313473363230184 3254 6496995 SGTC_1558 st069300 45.6 µM -0.488938367021768 0.31094974378873 no 2337 0.312442665942876 3339 24208000 SGTC_2528 xanthyletin 44.79 µM -0.492771918925203 0.3095940011562 no 2338 0.311086877204579 3238 65188 An natural product with antifungal activity of unknown mechanism. SGTC_593 1203-0218 61.7 µM -0.493048697846903 0.309496217694319 no 2339 0.310989089363082 3394 3666956 SGTC_131 0141-0277 33.849 µM -0.49361166696513 0.309297367469074 no 2340 0.310790229793161 3372 1547771 SGTC_1016 4226-1401 38 µM -0.494651991321913 0.308930054257343 no 2341 0.310422897773257 3346 2901613 SGTC_2725 haloperidol 53.21 µM -0.49490991911679 0.30883901576284 no 2342 0.310331854306531 3267 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_3291 9121177 71.43 µM -0.495119367085214 0.308765097404326 no 2343 0.310257931820011 3279 17015612 SGTC_2330 7979373 200 µM -0.497548882820411 0.307908239632011 no 2344 0.309401020247912 3252 1863007 SGTC_2656 pseudo-anisatin 100 µM -0.49855353168792 0.307554218899865 no 2345 0.30904697408564 3306 6708809 A neurotoxin. SGTC_193 1273-0060 1.558 µM -0.499054258826196 0.307377838272313 no 2346 0.308870580088262 3324 2847393 YHR072W ERG7 SGTC_3230 9131665 49.47 µM -0.499412501617064 0.307251674939631 no 2347 0.308744406906442 3310 15943720 SGTC_623 k072-0108 16.9 µM -0.499727585382689 0.3071407298894 no 2348 0.308633452998024 3329 5382803 SGTC_2794 7785382 27.27 µM -0.501689306769367 0.306450379935646 no 2349 0.307943043775473 3383 2205081 SGTC_3150 9097574 49.47 µM -0.502977625453319 0.305997380525597 no 2350 0.307490001583123 3382 17217476 SGTC_1436 4092-1007 8.32 µM -0.504112192337289 0.305598688960212 no 2351 0.307091269808738 3284 2881121 SGTC_370 0180-0345 38.7 µM -0.505662924239699 0.305054127938961 no 2352 0.306546649994626 3243 3989527 SGTC_51 1013-0126 23.419 µM -0.506024814637622 0.304927107142691 no 2353 0.306419614840738 3519 1627850 SGTC_2009 4012297 12.05 µM -0.506188927923266 0.304869512363941 no 2354 0.306362013471503 3347 45595307 SGTC_181 1447-1644 8.07 µM -0.506690042988957 0.304693678333153 no 2355 0.306186159010021 3348 534600 SGTC_1080 nisoldipine 24.4 µM -0.507213081021597 0.304510199961791 no 2356 0.306002658821145 3241 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class. SGTC_572 0960-0087 17.7 µM -0.507626331997166 0.304365268958303 no 2357 0.305857710223633 3313 6796365 SGTC_1141 3253-0389 52.6 µM -0.509011022161791 0.303879869104691 no 2358 0.30537224912673 3364 5402031 SGTC_383 2324-0395 7.37 µM -0.509967219984301 0.303544877895192 no 2359 0.305037213566779 3399 3146421 SGTC_1775 st081588 35.1725 µM -0.511308283989162 0.303075331988804 no 2360 0.304567602626214 3420 1426443 YGL099W LSG1 SGTC_358 0075-0058 9.45 µM -0.511554500133987 0.302989159799311 no 2361 0.304481418137326 3490 1069125 SGTC_1511 0906-3109 28.5 µM -0.512964268443106 0.302495971973816 no 2362 0.303988157743199 3379 2882180 SGTC_211 3455-0679 143.504 µM -0.513299871581961 0.30237861894327 no 2363 0.303870786899059 3391 748649 SGTC_2523 spermine 47.74 µM -0.513375850299872 0.302352053693036 no 2364 0.303844217587194 3365 1103 A DNA binding polyamine. SGTC_2175 5807670 165.306 µM -0.514813774442843 0.301849494449106 no 2365 0.303341579475913 3375 241186 SGTC_439 amiodarone 34.4 µM -0.515678203595874 0.301547554391047 no 2366 0.303039590177898 3257 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1 SGTC_3297 9117502 71.43 µM -0.515916696734497 0.301464274052471 no 2367 0.302956296012682 3374 7453720 SGTC_1586 deoxycorticosterone acetate 53.7 µM -0.516731091058549 0.301179970613171 no 2368 0.302671944571775 3383 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE. SGTC_1059 3448-6867 171 µM -0.517100855098202 0.301050926606704 no 2369 0.302542878368997 3388 3934407 SGTC_2866 9034245 58.44 µM -0.5172041027128 0.301014898657799 no 2370 0.302506844177496 3314 6462273 SGTC_1438 4092-1045 4 µM -0.519133337707851 0.300342055619262 no 2371 0.301833880895302 3326 1351342 SGTC_3185 9108267 49.47 µM -0.521138102911441 0.29964359153669 no 2372 0.301135284628655 3384 4910486 SGTC_2067 5224629 34.075 µM -0.521426661378418 0.29954311782231 no 2373 0.301034791281563 3427 2835000 SGTC_1129 3453-1384 223 µM -0.522050753778091 0.299325866159542 no 2374 0.300817496635327 3454 1084452 SGTC_908 3448-7491 47.7 µM -0.523401355169738 0.298855955654559 no 2375 0.300347490666114 3342 1203031 SGTC_1237 0330-0133 46.1 µM -0.524002680909004 0.298646846171167 no 2376 0.300138337604285 3334 X1237 YHR072W ERG7 SGTC_336 4111-0029 111 µM -0.525474711115628 0.298135232435387 no 2377 0.299626614395148 3345 3131175 SGTC_151 3013-0144 2.285 µM -0.52617730549561 0.297891182003734 no 2378 0.29938251031378 3422 906558 YHR107C CDC12 SGTC_733 4069-0007 56.1 µM -0.527113223658084 0.297566226700832 no 2379 0.299057482141513 3437 5717425 YNL287W SEC21 SGTC_876 0720-0963 56.8 µM -0.528366771961834 0.297131242374608 no 2380 0.298622397705135 3456 765861 SGTC_2461 5755302 26.15 µM -0.529183722533408 0.296847915092373 no 2381 0.298339003633355 3439 2788904 SGTC_3133 9127736 49.47 µM -0.529755656393197 0.296649635863905 no 2382 0.298140676920469 3449 27243420 SGTC_3128 9127691 49.47 µM -0.531859774414929 0.295920698430603 no 2383 0.297411559649063 3396 41316314 SGTC_226 1,3-diallylurea 8.28947 mM -0.531876924722591 0.295914760366384 no 2384 0.297405620085781 3367 74537 YKL182W FAS1 SGTC_208 k072-0098 12.366 µM -0.532106517146466 0.295835272335829 no 2385 0.297326111935435 3400 5948901 SGTC_1959 st077091 55.8 µM -0.532133507193834 0.295825928657353 no 2386 0.297316765885425 3337 821356 YKL052C ASK1 SGTC_1336 1486-0901 104 µM -0.532239247449698 0.295789323767703 no 2387 0.297280151691884 3393 5006114 SGTC_2313 7726885 200 µM -0.532738417657532 0.295616550414016 no 2388 0.297107334141417 3399 726423 SGTC_3151 9099821 49.47 µM -0.533819407190493 0.295242556204308 no 2389 0.296733242660985 3396 17174189 SGTC_2329 6138490 200 µM -0.534983983005286 0.294839887199046 no 2390 0.296330466477064 3420 720019 SGTC_997 3996-0078 137 µM -0.536652716471265 0.294263340045743 no 2391 0.295753761433471 3355 735687 SGTC_1500 4488-1866 171 µM -0.536979510563146 0.294150493742504 no 2392 0.295640883615381 3493 2900003 SGTC_446 go6976 132 µM -0.537427123072828 0.293995959709978 no 2393 0.295486306100733 3412 3501 A protein kinase C inhibitor. SGTC_1869 3',7'-dimethoxyflavone 40.3 µM -0.538488063541605 0.29362982993692 no 2394 0.295120071806852 3364 688664 SGTC_2781 5567276 71.43 µM -0.538825989891779 0.293513256142171 no 2395 0.295003464289859 3446 2853274 SGTC_2080 5212524 12.4 µM -0.539575354617246 0.293254825747939 no 2396 0.294744958373073 3432 260183 SGTC_3307 9126885 69.2785 µM -0.539936470256656 0.293130326924649 no 2397 0.294620422790577 3314 24824909 SGTC_1296 1068-0102 11.9 µM -0.540453191167536 0.29295222401398 no 2398 0.29444226686809 3394 767053 SGTC_3343 9148379 18.9835 µM -0.540587982491491 0.292905772517976 no 2399 0.294395801463521 3469 1955036 SGTC_2806 7952793 58.44 µM -0.540764629677067 0.292844901921051 no 2400 0.294334912589017 3415 2972490 SGTC_3153 9100258 49.47 µM -0.5419232164027 0.292445811844871 no 2401 0.293935701226561 3331 25236848 SGTC_1451 4152-0210 104 µM -0.542176812473628 0.292358491159904 no 2402 0.293848353668089 3458 659563 SGTC_341 1486-1430 230 µM -0.542759228731803 0.292157993794947 no 2403 0.293647794141692 3323 2054753 YPL210C SRP72 SGTC_556 4058-0063 51.5 µM -0.543639000375265 0.291855252930473 no 2404 0.293344958208947 3415 6615692 SGTC_2047 4141938 200 µM -0.544539158898168 0.29154564801117 no 2405 0.293035254561548 3354 3807862 SGTC_2825 7998094 58.44 µM -0.544805323592093 0.291454131373443 no 2406 0.292943708449074 3369 2987815 SGTC_2716 st080858 38.6235 µM -0.545776198809904 0.291120424499066 no 2407 0.292609892969764 3448 5296050 SGTC_2407 paclitaxel 400 µM -0.546619211683432 0.290830810976499 no 2408 0.292320183756112 3475 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_957 1187-1561 14.1 µM -0.547008788700498 0.290697018951786 no 2409 0.292186347074071 3426 1538454 SGTC_367 0335-0881 7.1 µM -0.547246982859294 0.29061523036612 no 2410 0.292104531048357 3459 23828853 SGTC_13 0199-0087 65 µM -0.548410311589056 0.290215933644318 no 2411 0.291705098830542 3453 4589825 SGTC_3033 9090887 49.47 µM -0.549163489260772 0.289957552824244 no 2412 0.291446628975811 3367 19325384 SGTC_1148 3909-7663 27.7 µM -0.551455336044173 0.289171989207961 no 2413 0.290660788105732 3498 4084526 SGTC_601 0986-0029 62.9 µM -0.552047374638135 0.288969222171823 no 2414 0.290457947900476 3436 24747981 SGTC_2658 polymyxin b sulfate 77.05 µM -0.553673611514522 0.28841259753737 no 2415 0.289901119013615 3409 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides.  YIL048W NEO1 SGTC_1697 st025554 27.742 µM -0.555550513725163 0.287770804732156 no 2416 0.289259084519346 3426 1269519 SGTC_2277 7947813 106.88 µM -0.55606580150913 0.287594724007115 no 2417 0.289082936325097 3529 1246798 SGTC_2336 9001819 198.65 µM -0.556162580695829 0.287561658946873 no 2418 0.289049858539486 3550 2989602 SGTC_452 diindolylmethane 8 µM -0.556585258710975 0.287417270101896 no 2419 0.288905413918536 3445 3071 Inhibits expression of several cancer promoting factors. SGTC_2114 5491910 81.25 µM -0.558502546261715 0.286762746381291 no 2420 0.288250633139039 3472 2849228 SGTC_827 3253-0474 693 µM -0.558669371922854 0.286705828859336 no 2421 0.288193692935811 3480 5402065 SGTC_2989 9073649 71.4286 µM -0.559003776449478 0.28659175296972 no 2422 0.288079571429806 3466 21367202 SGTC_637 1181-0519 7.26 µM -0.561535169234197 0.285728914440799 no 2423 0.287216381040097 3469 6252091 YGR060W ERG25 SGTC_2923 7992654 58.14 µM -0.56162347604984 0.285698836918155 no 2424 0.287186291034076 3411 2985126 SGTC_2081 5214970 32.255 µM -0.561761982014252 0.28565166447394 no 2425 0.287139098981803 3441 2063512 SGTC_117 lucigenin 22.078 µM -0.56257514659099 0.285374791172216 no 2426 0.286862109863564 3454 65100 An acridine derivative; a dye stuff and potential carcinogen. SGTC_918 glabranin 770.725 nM -0.562766789812724 0.285309557447538 no 2427 0.286796848670038 3426 124049 Also referred to as licorice root. SGTC_2692 st077426 47.7 µM -0.563190406372604 0.285165387179392 no 2428 0.286652617448505 3481 25238571 SGTC_250 brefeldin a 552.239 µM -0.563557538758195 0.2850404683745 no 2429 0.286527645555861 3389 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.  SGTC_2860 9025725 38.96 µM -0.564990178338081 0.284553254632101 no 2430 0.286040222328064 3340 40546248 SGTC_1210 3013-0140 750 nM -0.566246823443664 0.284126220996636 no 2431 0.285613001896996 3485 905973 SGTC_280 3448-3607 3.04 µM -0.567684052678476 0.283638197236286 no 2432 0.285124761011953 3475 626179 SGTC_1202 1988-0068 29.6 µM -0.567696133518423 0.283634096783779 no 2433 0.285120658718616 3365 2850480 SGTC_3233 9132340 49.47 µM -0.568428465243608 0.283385583388117 no 2434 0.284872033242676 3394 17682950 SGTC_42 0133-0086 60.653 µM -0.568708237138107 0.283290671651296 no 2435 0.284777078433242 3409 162923 Model of phenazepam hydroxylation. SGTC_1044 1222-0021 1.78 µM -0.568780212071947 0.28326625684668 no 2436 0.284752652524872 3433 4306703 SGTC_1838 st055369 84.5 µM -0.569782132068936 0.282926497804064 no 2437 0.284412737946072 3450 676036 SGTC_2784 7567673 72.73 µM -0.570493757419277 0.28268529889374 no 2438 0.28417142746824 3509 3471247 SGTC_1692 fluoroquinolonic acid 71 µM -0.572468430138323 0.282016519626392 no 2439 0.283502333849382 3484 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2 SGTC_2426 5582046 32.21 µM -0.573717402090225 0.281593913409142 no 2440 0.283079525191478 3511 2251934 SGTC_80 0159-0065 512.242 µM -0.574052186060768 0.281480686742233 no 2441 0.282966243785094 3463 1548079 SGTC_955 1216-0110 33 µM -0.574114478903649 0.281459621219168 no 2442 0.282945168054534 3456 3619719 SGTC_3097 9117246 49.47 µM -0.57613826897676 0.280775651792463 no 2443 0.282260863217996 3523 16423892 SGTC_3248 9135562 49.47 µM -0.578269552272064 0.28005622351084 no 2444 0.28154107377662 3492 17650701 SGTC_1489 4065-0444 182 µM -0.579434155547882 0.279663482120166 no 2445 0.281148131600277 3472 2877968 SGTC_1443 4112-3303 14 µM -0.580262909102213 0.279384162862295 no 2446 0.280868667981749 3477 704433 SGTC_2682 pyrogallin 40.03 µM -0.580410754913053 0.279334347843346 no 2447 0.280818827080411 3486 822798 An ATP competetive kinase inhibitor. SGTC_3168 9103419 49.47 µM -0.580484195392005 0.279309604486487 no 2448 0.280794070852283 3452 16649256 SGTC_1521 st012942 49.4 µM -0.581899981481234 0.278832810142893 no 2449 0.280317026491757 3496 24207259 SGTC_2006 4011487 200 µM -0.582844179180942 0.278515052953498 no 2450 0.279999100573511 3536 45595294 SGTC_3270 9137563 49.47 µM -0.583355628433116 0.278343005190567 no 2451 0.279826960749403 3448 17015724 SGTC_1275 0867-0008 21.1 µM -0.585437207068812 0.277643312399651 no 2452 0.279126888456229 3409 3422836 SGTC_2852 9023854 51.95 µM -0.586081947975635 0.277426766410508 no 2453 0.278910223353649 3550 19798528 SGTC_1735 st034310 56.75 µM -0.586441464153923 0.277306053328084 no 2454 0.278789443530142 3522 871153 SGTC_568 1193-0097 7.48 µM -0.588915303723407 0.276476120853426 no 2455 0.277959045564437 3430 3646150 SGTC_3107 9121808 49.47 µM -0.589306550470988 0.276344975635142 no 2456 0.277827825729062 3474 662681 SGTC_612 0302-0167 22.4 µM -0.59243648493592 0.275296927048951 no 2457 0.27677917041253 3505 235821 SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM -0.594029521025728 0.27476425626916 no 2458 0.276246184141853 3558 23847180 SGTC_477 mead ethanolamide 10 µM -0.596537300493419 0.273926749478608 no 2459 0.27540817157686 3412 16061185 SGTC_474 dl-dihydrosphingosine 5 µM -0.598343385670034 0.273324365649905 no 2460 0.274805416588145 3559 3058739 A sphingolipid protein kinase C inhibitor. SGTC_3269 9137823 49.47 µM -0.599975293245753 0.272780640103259 no 2461 0.274261350709468 3420 17682936 SGTC_2269 7935389 174.42 µM -0.599977091707972 0.272780041180506 no 2462 0.274260751409049 3487 97605 SGTC_2066 5222451 176 µM -0.600059527360714 0.272752589211753 no 2463 0.274233282123181 3513 2281147 SGTC_891 0929-0073 133 µM -0.600070451858256 0.272748951338144 no 2464 0.27422964195378 3516 5603632 SGTC_373 0844-0104 25.9 µM -0.601037080221477 0.272427158020713 no 2465 0.273907644663182 3530 5375804 SGTC_1505 k297-0037 20.6 µM -0.601300611736955 0.272339460355759 no 2466 0.273819891102558 3438 4089396 SGTC_603 3794-0023 45.9 µM -0.602016922633573 0.272101158267303 no 2467 0.273581436462702 3515 3802260 SGTC_3320 9137005 35.139 µM -0.602194148837579 0.27204221470983 no 2468 0.27352245502181 3479 4908713 SGTC_1231 0242-0792 125 µM -0.602281386004448 0.272013202884576 no 2469 0.273493424528587 3500 3707635 SGTC_1215 3852-0577 11.2 µM -0.602818043642209 0.271834764440024 no 2470 0.273314870948478 3563 2884876 SGTC_465 cgp-37157 41 µM -0.603360047679731 0.271654607455873 no 2471 0.273134597165615 3447 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange. SGTC_3021 9087658 49.47 µM -0.604751555706679 0.271192355806306 no 2472 0.272672043280149 3527 25237042 SGTC_2552 juarezic acid 87.02 µM -0.60608558005903 0.27074956843522 no 2473 0.272228962952513 3583 1549512 SGTC_2309 7664088 163.95 µM -0.606124866816745 0.270736533906644 no 2474 0.272215919748875 3548 704922 SGTC_1397 3532-0190 20.1 µM -0.606468262334719 0.2706226157597 no 2475 0.272101925659662 3453 5322280 SGTC_839 0122-0028 230 µM -0.607766542889038 0.2701921401957 no 2476 0.271671161102556 3489 759448 SGTC_69 0096-0274 206.684 µM -0.608239579592791 0.270035378873606 no 2477 0.271514293746408 3668 6741392 SGTC_1323 1348-1351 11.2 µM -0.608491900560791 0.269951779942308 no 2478 0.271430638094786 3452 6989654 SGTC_2795 7780010 54.55 µM -0.60861029838515 0.269912556864992 no 2479 0.271391388363695 3511 953673 SGTC_738 1315-0003 72.4 µM -0.608950972324796 0.269799713609369 no 2480 0.27127846827782 3540 6251474 SGTC_745 0469-0705 296 µM -0.610479127050481 0.269293825543204 no 2481 0.270772233064558 3626 3486736 SGTC_1637 st007924 17.4 µM -0.611900144975784 0.268823831819691 no 2482 0.270301912849623 3544 683336 SGTC_3259 9138485 49.47 µM -0.61255327621332 0.268607950591395 no 2483 0.270085880369245 3676 17646153 SGTC_2131 toluylene red 5.2905 µM -0.612891960136748 0.268496038795353 no 2484 0.269973889846028 3492 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain. SGTC_419 nsc-638432 893 µM -0.614013412641879 0.268125643086351 no 2485 0.269603232018767 3492 368090 SGTC_622 1348-1566 26.3 µM -0.614367143610304 0.268008865447526 no 2486 0.269486371244502 3529 7340407 SGTC_1771 st048882 4.1505 µM -0.614428019154733 0.26798877111228 no 2487 0.269466262579889 3427 4580403 SGTC_3030 9087619 49.47 µM -0.617572344378226 0.266951897188723 no 2488 0.268428639693316 3505 25236973 SGTC_3214 9129694 49.47 µM -0.619572191528513 0.266293482679442 no 2489 0.267769739830089 3526 17158655 SGTC_2151 5563267 85.4165 µM -0.619576234536769 0.266292152423005 no 2490 0.267768408585353 3518 5310824 SGTC_3063 1327-0034 4 µM -0.621023759437719 0.265816094787389 no 2491 0.267291995272408 3502 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_2440 5628896 157.78 µM -0.622133793601103 0.265451322538976 no 2492 0.266926947795356 3549 5522048 SGTC_630 4356-0227 183 µM -0.623983045480949 0.264844197880193 no 2493 0.266319359850731 3562 779312 SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM -0.624395698706303 0.264708816811495 no 2494 0.266183874588503 3490 279621 SGTC_3006 9075424 71.4286 µM -0.624597005074903 0.264642786065905 no 2495 0.266117792906132 3500 7465181 SGTC_1517 deoxycholic acid methyl ester 49.2 µM -0.626253149313034 0.264099870358048 no 2496 0.265574455465203 3567 229346 A bile salt which induces apoptosis. SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM -0.626358150869334 0.264065467981089 no 2497 0.265540026189002 3530 5379071 SGTC_2369 9071472 200 µM -0.626494323797801 0.264020856115532 no 2498 0.265495379410184 3561 17296037 SGTC_3218 9131285 49.47 µM -0.627381968722484 0.263730147260551 no 2499 0.26520444218273 3607 17156417 SGTC_2428 5615643 7.78 µM -0.627709308907994 0.263622982671773 no 2500 0.265097193030572 3550 2253075 SGTC_3158 9100007 49.47 µM -0.628179275157348 0.263469164034857 no 2501 0.264943252659513 3530 19297233 SGTC_1571 st070080 73.4 µM -0.629119542528027 0.263161554731358 no 2502 0.264635398649664 3604 4315245 SGTC_935 2996-0153 430 µM -0.629281410925152 0.263108617860217 no 2503 0.264582419497125 3569 23738523 SGTC_546 peri-Naphthalide 147 µM -0.629283505685389 0.263107932832864 no 2504 0.264581733922304 3486 223824 A penicillin ester. SGTC_846 0335-0850 148 µM -0.630304518661674 0.262774150235217 no 2505 0.26424768357596 3551 6819598 SGTC_411 enrofloxacin 100 µM -0.630364895612538 0.262754418998846 no 2506 0.264227936449815 3625 71188 A bacterial gyrase inhibitor. SGTC_1731 st035964 63 µM -0.631260423131602 0.262461848889841 no 2507 0.263935129917259 3482 6739575 SGTC_1787 fluconazole 80 µM -0.631596355735805 0.262352142263674 no 2508 0.263825334244774 3515 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C SGTC_971 1315-0384 26.7 µM -0.631753778986448 0.262300740112158 no 2509 0.263773890297483 3545 6769120 SGTC_974 1326-0144 138 µM -0.632088526794049 0.262191454744576 no 2510 0.263664515911866 3563 5411856 SGTC_1967 st070177 51.4 µM -0.632139301840693 0.26217488021498 no 2511 0.26364792786293 3608 5729214 SGTC_1831 st055328 12 µM -0.633286748652876 0.261800461656388 no 2512 0.263273202595397 3577 1103068 SGTC_427 1354-0053 47.3 µM -0.633797398450297 0.261633921900812 no 2513 0.263106525612016 3631 6813657 SGTC_270 tamoxifen 5.46 µM -0.636468672214124 0.260763618335926 no 2514 0.26223549684327 3667 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  YIL048W NEO1 SGTC_2829 7992743 58.44 µM -0.636494069134779 0.260755351148716 no 2515 0.262227222702084 3527 16462845 SGTC_2206 7254556 146.969 µM -0.636533451291276 0.260742531764378 no 2516 0.262214392532244 3553 4398905 SGTC_2894 9048625 32.47 µM -0.637316463482842 0.260487718845029 no 2517 0.261959364615362 3643 4092861 SGTC_2797 7859098 81.82 µM -0.638119146008465 0.260226637845062 no 2518 0.261698062118759 3570 972681 SGTC_2232 chlorophetanol 41.5365 µM -0.638261043376157 0.260180498252719 no 2519 0.261651883254892 3618 15907 An antifungal of unknown mechanism. YFR051C RET2 SGTC_1846 st056244 14.8 µM -0.638908427034083 0.259970047382193 no 2520 0.261441252773962 3540 5393182 SGTC_324 1315-0088 19.6 µM -0.639830952491152 0.259670305433264 no 2521 0.261141253631255 3540 6787421 SGTC_1720 st037298 9.481 µM -0.64113981507447 0.259245343230556 no 2522 0.260715924011885 3560 597396 SGTC_1927 st060202 13.8 µM -0.64236206460379 0.258848827392441 no 2523 0.260319062409162 3584 688887 SGTC_266 formosanin C 406 nM -0.643817427651629 0.258377095691862 no 2524 0.259846915648836 3546 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1 SGTC_2473 5854593 8.94 µM -0.643857772888732 0.258364024803153 no 2525 0.259833833202109 3533 2872951 SGTC_1901 st060216 58.6 µM -0.64644491368006 0.257526569242605 no 2526 0.258995630650663 3596 688792 SGTC_1307 1187-1599 12.2 µM -0.647590452896627 0.257156209919118 no 2527 0.258624936907937 3547 1538471 SGTC_1555 citronellol 128 µM -0.647912258967225 0.257052218042662 no 2528 0.258520850681746 3560 8842 A terpine precursor. SGTC_288 1315-0019 35.1 µM -0.651784950574785 0.255802472388733 no 2529 0.257269955710218 3618 6811474 SGTC_2433 5607874 27.82 µM -0.653198054840445 0.25534724447793 no 2530 0.256814302047798 3603 2252428 SGTC_539 4859-0462 2.54 µM -0.653911751530778 0.255117489960505 no 2531 0.256584331207971 3608 46499474 YNL221C | YBR257W POP1 | POP4 SGTC_2884 9058502 51.95 µM -0.654089388124964 0.255060321679148 no 2532 0.256527108949829 3597 6471554 SGTC_3222 9128301 49.47 µM -0.654815857076633 0.254826593998168 no 2533 0.256293159964109 3602 4911358 SGTC_269 exalamide 29 µM -0.654958200316481 0.254780810885261 no 2534 0.256247333383791 3569 3316 A derivative of salicylamide. SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM -0.65513423121693 0.254724198468834 no 2535 0.256190667165036 3596 6708561 SGTC_1668 st014914 51.6 µM -0.655412977302141 0.254634565810962 no 2536 0.256100949202943 3608 2839556 SGTC_334 1502-1024 68.5 µM -0.655930779068788 0.254468107062713 no 2537 0.255934331641725 3616 3296216 SGTC_2406 ethylparaben 405.7 µM -0.656063473598248 0.25442545867251 no 2538 0.255891642479877 3437 8434 A possible steroid mimic. SGTC_355 1311-2252 105 µM -0.656084761861894 0.254418616914161 no 2539 0.255884794177721 3560 5338538 SGTC_2257 7960413 200 µM -0.656495276407979 0.254286701982284 no 2540 0.255752752906894 3588 2974689 YIL048W NEO1 SGTC_1618 st003135 44.5 µM -0.656711894027431 0.254217108433051 no 2541 0.25568309257646 3553 1270615 SGTC_2729 fluphenazine 10.66 µM -0.657266483611028 0.254038978899714 no 2542 0.255504791704802 3549 3372 An atypical antipsychotic. SGTC_3089 9117425 49.47 µM -0.659599449762989 0.253290367406757 no 2543 0.254755453730295 3552 9401657 SGTC_206 4546-0025 72.014 µM -0.661409238499691 0.252710435013246 no 2544 0.254174951413046 3628 6620745 YIL048W NEO1 SGTC_978 1416-0512 87.4 µM -0.661788241468511 0.252589075139464 no 2545 0.254053471484084 3632 6814003 SGTC_685 1278-0033 54.9 µM -0.662360925813791 0.252405755154503 no 2546 0.253869969630989 3667 3590572 SGTC_599 1935-0052 86.5 µM -0.662909370903399 0.252230260070137 no 2547 0.253694299855948 3598 9557311 SGTC_2292 7671323 168.05 µM -0.663960709414626 0.251894025803342 no 2548 0.253357729294735 3610 937504 SGTC_2724 maprotiline 69.64 µM -0.664687652499208 0.251661676615255 no 2549 0.253125146485073 3605 4011 A tricyclic antidepressant. SGTC_740 k014-0057 261 µM -0.666067904863937 0.251220825144766 no 2550 0.252683848979944 3615 4012779 SGTC_2640 pentamidine 10.38 µM -0.667901915517906 0.250635676101303 no 2551 0.252098102296253 3639 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_351 caspofungin 25 nM -0.668401926444572 0.250476270783347 no 2552 0.251938533058937 3667 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1 SGTC_1373 2887-0003 58.5 µM -0.668709762395435 0.250378158279474 no 2553 0.251840319427369 3610 776948 SGTC_1274 0865-0114 173 µM -0.670752904989133 0.249727490942944 no 2554 0.251188976854227 3637 870624 SGTC_836 0330-0104 1.35 µM -0.675757192333316 0.248137606352241 no 2555 0.249597408796809 3650 46494820 SGTC_3010 9080089 71.4286 µM -0.675857063913525 0.248105931743101 no 2556 0.249565700163367 3641 17027233 SGTC_1383 3049-0032 20.7 µM -0.67837383421535 0.247308442033322 no 2557 0.248767347534658 3664 712864 SGTC_175 3793-3120 23.7 µM -0.679214386121362 0.247042401710154 no 2558 0.248501016657206 3645 5322297 SGTC_39 0986-0283 58.349 µM -0.681017971155138 0.246472072056282 no 2559 0.247930059580739 3676 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2 SGTC_2022 5136654 200 µM -0.68226494214714 0.246078167793329 no 2560 0.247535718359766 3641 1713771 SGTC_1681 tripelennamine 100 µM -0.683091089792153 0.24581738303485 no 2561 0.247274642681743 3648 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist. SGTC_1592 4',5'-dihydroxyflavone 8.85 µM -0.683838891521423 0.245581457209957 no 2562 0.24703845254787 3653 688669 SGTC_1700 st030840 7.9285 µM -0.685043604227717 0.245201635349629 no 2563 0.246658202931123 3669 5499307 SGTC_1150 3909-7983 10.9 µM -0.68562683413514 0.245017868143607 no 2564 0.246474227772884 3649 23965914 SGTC_2507 purpurin 79.67 µM -0.686014671935889 0.244895707158654 no 2565 0.246351928191021 3645 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1 SGTC_1911 st060208 74.3 µM -0.686872059979937 0.244625763801015 no 2566 0.246081677554207 3671 688783 SGTC_2311 7694451 200 µM -0.691752678049156 0.243092188168211 no 2567 0.244546329592948 3627 2163142 SGTC_3300 9124615 50.48 µM -0.693210540288862 0.242635112835465 no 2568 0.244088717231437 3684 24824903 SGTC_1005 4092-0690 4.4 µM -0.694243123300329 0.242311654630178 no 2569 0.243764876538862 3655 1529343 SGTC_781 4335-2806 94.4 µM -0.694682767389697 0.24217400640807 no 2570 0.243627064932222 3764 845254 SGTC_2164 5685496 200 µM -0.695232712937268 0.242001883582575 no 2571 0.243454737283548 3645 759046 SGTC_1055 3448-0672 86 µM -0.696115122673589 0.241725844289486 no 2572 0.243178368304946 3644 748378 SGTC_1767 st044992 70.3 µM -0.697308607000973 0.241352765326664 no 2573 0.242804841399118 3663 9600693 SGTC_2463 5473429 200 µM -0.698517769311134 0.240975104745194 no 2574 0.242426724607802 3663 5399405 SGTC_453 enantio-paf c16 10 µM -0.699247100612083 0.24074746642636 no 2575 0.242198809958263 3661 13871343 A lipid and platelet activating factor SGTC_2445 5742597 35.57 µM -0.699288369856143 0.24073458900114 no 2576 0.242185916870819 3643 1774255 SGTC_2575 plumbagin 510 nM -0.699464828040461 0.240679532199696 no 2577 0.242130793069717 3642 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_2158 5657123 3.6195 µM -0.70169564563832 0.239984085105315 no 2578 0.241434494561044 3663 2858827 SGTC_2140 5586273 200 µM -0.702193657277957 0.23982898202764 no 2579 0.241279200301749 3664 854421 SGTC_2010 4012422 159 µM -0.702452549811696 0.239748372933034 no 2580 0.241198491660966 3674 952393 SGTC_284 0988-0104 32.6 µM -0.704803126337835 0.239017171446004 no 2581 0.240466381357341 3696 4666532 SGTC_2342 7990637 118.86 µM -0.705082404687118 0.238930376526929 no 2582 0.24037947786096 3743 2033102 YER133W GLC7 SGTC_2585 alliin 100 µM -0.705154864324699 0.238907860131094 no 2583 0.240356933273659 3752 87310 A garlic compound which reacts with lipids. SGTC_1347 1493-0251 600 nM -0.705365400327597 0.238842443921051 no 2584 0.240291435103065 3714 3986378 SGTC_3305 9127027 53.8275 µM -0.706001225534936 0.238644944437757 no 2585 0.240093687658581 3628 41905295 SGTC_1976 st070609 63.5 µM -0.707456992857384 0.238193091985051 no 2586 0.239641265005695 3623 682556 SGTC_1821 st053465 65.6 µM -0.710907699991911 0.237123909384025 no 2587 0.23857071708105 3659 675086 SGTC_1888 azatryptophan 97.5 µM -0.711150181404847 0.237048877140062 no 2588 0.2384955881703 3661 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides SGTC_1350 1495-0454 146 µM -0.711584067266634 0.236914650221146 no 2589 0.238361188042582 3701 1069057 SGTC_3086 9117350 49.47 µM -0.712034265260576 0.236775421161603 no 2590 0.238221778940545 3618 2679265 SGTC_1961 st076550 68.7 µM -0.714288931176939 0.236078816467109 no 2591 0.237524267637467 3677 1579337 SGTC_3094 9117742 49.47 µM -0.714400682767757 0.236044318935402 no 2592 0.237489724956675 3649 17149698 SGTC_651 3253-0966 34.4 µM -0.715641674559771 0.23566141356261 no 2593 0.237106316854187 3727 781462 SGTC_1127 asiatic acid 681.4 nM -0.715995847312679 0.235552197185872 no 2594 0.236996956545875 3681 470603 A kinase inhibitor which arrests cells at G2/M. SGTC_348 k064-0012 10.7 µM -0.715996086083788 0.235552123565362 no 2595 0.236996882828262 3642 5066323 SGTC_1564 D-Arginine 115 µM -0.716994308615957 0.235244451703399 no 2596 0.236688804213771 3678 71070 D-isomer of arginine; arginine decarboxylase inhibitor. SGTC_3265 9137266 49.47 µM -0.717791244293084 0.23499897979192 no 2597 0.236443006419015 3643 17224265 SGTC_378 3970-0959 8.33 µM -0.72015573410384 0.2342715037908 no 2598 0.235714557527065 3715 6615653 SGTC_1234 0326-0494 15.5 µM -0.721332958475466 0.233909775791328 no 2599 0.235352341804913 3739 1547813 SGTC_161 4065-0411 162.148 µM -0.722322865845822 0.233605844717895 no 2600 0.235047998896683 3735 1906281 YLR208W SEC13 SGTC_1815 st051655 58.2 µM -0.725160454833425 0.232735835007564 no 2601 0.23417679997477 3676 5984156 SGTC_1638 st008370 60.6 µM -0.725336010666944 0.232682068496948 no 2602 0.234122959467954 3720 24207134 SGTC_865 0488-0499 301 µM -0.725908265910087 0.232506854999936 no 2603 0.233947504426214 3704 9634651 SGTC_165 k038-0023 64.381 µM -0.726063641170163 0.232459294765296 no 2604 0.233899878518749 3728 46368543 SGTC_3261 9137475 49.47 µM -0.726814508006213 0.232229531334763 no 2605 0.233669797175733 3594 17027690 SGTC_2831 7999036 19.48 µM -0.72697053333281 0.232181803826192 no 2606 0.233622003494353 3742 2988270 SGTC_1570 verbenone 133 µM -0.727052175474768 0.232156832004987 no 2607 0.233596997031985 3721 29025 A natural terpanoid with antifungal properties. SGTC_1213 1315-0166 115 µM -0.727277848939722 0.232087813207544 no 2608 0.233527882425004 3750 768401 SGTC_2914 7968218 45.32 µM -0.727577518599134 0.23199618145591 no 2609 0.233436123323576 3685 2977111 SGTC_1676 st018489 23.4 µM -0.729171991370632 0.231508969032894 no 2610 0.232948230901491 3765 3696235 SGTC_2669 eugenol 100 µM -0.72942881284051 0.23143054718001 no 2611 0.232869699143685 3688 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism. SGTC_692 k241-0027 77.8 µM -0.731316583616128 0.230854560786485 no 2612 0.232292901681309 3756 3600480 SGTC_3095 9117207 49.47 µM -0.731980329901618 0.230652232489905 no 2613 0.232090286868559 3701 17015229 SGTC_68 0986-0284 82.829 µM -0.73428108122977 0.22995166708487 no 2614 0.231388722915146 3772 423278 YIL048W NEO1 SGTC_665 3914-0008 307 µM -0.734795539616233 0.229795180583528 no 2615 0.231232011989938 3709 1069549 SGTC_501 nsc-95397 161 µM -0.735222679606045 0.229665299665116 no 2616 0.231101944421559 3740 262093 SGTC_2748 diazoxide 86.69 µM -0.735233439235682 0.229662028503913 no 2617 0.231098668554939 3698 3019 A potassium channel activatior. SGTC_2819 7996655 46.38 µM -0.735345099516033 0.229628082893189 no 2618 0.231064674102003 3657 6456960 SGTC_2477 5967686 25.23 µM -0.735670610419738 0.229529141038276 no 2619 0.230965589750591 3752 776118 SGTC_228 caffeine 993.056 µM -0.737877027415431 0.228859111581841 no 2620 0.230294590007661 3732 2519 Caffeine is a phosphodiesterase inhibitor. SGTC_2228 7354201 200 µM -0.73787931501539 0.22885841746946 no 2621 0.230293894885318 3754 753451 SGTC_2941 9056145 11.23 µM -0.737925015822667 0.22884455100229 no 2622 0.230280008239771 3619 2119517 SGTC_2765 myclobutanil 7.74 µM -0.738200281119509 0.228761040413249 no 2623 0.230196376042795 3757 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11 SGTC_2953 9074162 66.49 µM -0.738334562184734 0.228720308138944 no 2624 0.230155584401979 3665 16451992 SGTC_276 colchicine 750 µM -0.740219022141789 0.228149113435121 no 2625 0.229583553579211 3764 2833 A microtubule depolymerizer. SGTC_940 3232-1287 54.8 µM -0.743171637222406 0.227255767442145 no 2626 0.228688886342128 3693 1585493 YIL048W NEO1 SGTC_29 0299-0004 12.984 µM -0.743252157487955 0.227231432798614 no 2627 0.228664515476111 3640 16871 A napthoquinone isolated from Swertia calycina. SGTC_1859 st055998 20 µM -0.743275817114617 0.227224282721563 no 2628 0.22865735475372 3724 676301 SGTC_50 0929-0078 56.389 µM -0.743387341712717 0.227190581045676 no 2629 0.22862360288702 3651 1377751 SGTC_690 glyoxal 20.3 µM -0.747481036498555 0.225955456688538 no 2630 0.227386622764381 3649 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins. SGTC_1895 st058434 18.3 µM -0.749335498200318 0.225397191778731 no 2631 0.226827508600179 3743 5393175 SGTC_532 1548-0774 215 µM -0.751815320244173 0.224651890923105 no 2632 0.226081063767815 3843 5932993 SGTC_2960 9079389 5.97 µM -0.753075674012458 0.224273632921307 no 2633 0.225702220698567 3727 16457355 SGTC_3240 9133527 49.47 µM -0.753704987986004 0.224084898331094 no 2634 0.22551319305636 3727 17617455 SGTC_1315 1237-0019 3.69 µM -0.754857550479411 0.223739472766786 no 2635 0.225167229194541 3744 825140 SGTC_1752 st044819 83.042 µM -0.756655416785245 0.223201253059972 no 2636 0.224628165717104 3771 441209 YML126C ERG13 SGTC_547 1120-0019 610 nM -0.757646472399609 0.222904880291206 no 2637 0.224331325701675 3699 3676939 SGTC_337 1315-0038 354 µM -0.758698456734831 0.222590532362836 no 2638 0.224016480149859 3745 1626437 SGTC_663 1486-0733 13.9 µM -0.75933179883312 0.222401402654356 no 2639 0.223827050030469 3789 722445 YPR165W RHO1 SGTC_2298 7976326 193.81 µM -0.759935475289299 0.222221217102091 no 2640 0.223646577565961 3657 2235818 SGTC_522 1273-0010 11.6 µM -0.760486634064307 0.22205677981735 no 2641 0.223481877841669 3841 5705015 SGTC_3292 9120825 59.784 µM -0.761362293192235 0.221795671303468 no 2642 0.22322035141785 3770 24824900 SGTC_368 fentichlor 4.58 µM -0.76154345370468 0.221741673839845 no 2643 0.223166267348576 3790 7329 A pesticide. SGTC_1073 triclabendazole 3.09 µM -0.761552268181607 0.221739046751428 no 2644 0.223163636045027 3849 50248 An antihelmetic and likely tubulin inhibitor. SGTC_3237 9133362 49.47 µM -0.761855394600216 0.221648713028027 no 2645 0.22307315729259 3711 43845137 SGTC_2502 avocadyne acetate 18.59 µM -0.765448828635156 0.220579448886622 no 2646 0.222002163206362 3750 3952079 SGTC_1991 st073000 8.92 µM -0.765698673160663 0.220505215062499 no 2647 0.221927808370836 3826 4301969 YIL048W NEO1 SGTC_1106 tegaserod maleate 11.7 µM -0.765716463083277 0.220499929865387 no 2648 0.22192251455361 3810 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation. SGTC_2836 9010338 19.48 µM -0.765949118857761 0.220430816988056 no 2649 0.221853288898503 3754 2994051 SGTC_1382 3002-2117 298 µM -0.766788386213969 0.220181606876373 no 2650 0.221603671275616 3818 1497314 SGTC_2187 6125751 200 µM -0.768106266975891 0.219790604660079 no 2651 0.221212026995346 3797 874498 SGTC_606 k015-0008 38.6 µM -0.769252143780332 0.219450958501767 no 2652 0.220871820431101 3823 1970475 SGTC_1833 st055984 71 µM -0.769924403727663 0.219251836227046 no 2653 0.22067236845308 3830 676288 SGTC_1271 0832-2808 169 µM -0.770482008277763 0.219086753512203 no 2654 0.220507011747606 3832 3663794 SGTC_462 ag-879 158 µM -0.770658860793538 0.219034410024928 no 2655 0.220454581261923 3789 6809654 Ag-879 is a 5-Lipoxygenase inhibitor. SGTC_164 4100-3994 89.624 µM -0.771541662908846 0.21877323242287 no 2656 0.220192968679275 3779 4615967 SGTC_654 1124-0271 80.9 µM -0.774785434257114 0.217815100942015 no 2657 0.219233228806127 3793 5403748 SGTC_142 0335-0849 62.6745 µM -0.775609757937603 0.217572001941576 no 2658 0.218989718548381 3803 3889043 YPR107C YTH1 SGTC_559 1550-0661 158 µM -0.776884580862208 0.217196355966468 no 2659 0.218613434550737 3852 5830875 SGTC_1243 0416-0003 5.65 µM -0.777792886999614 0.216928938455868 no 2660 0.218345560964237 3812 2141977 SGTC_1345 1488-0192 31.4 µM -0.779857670709476 0.216321746987808 no 2661 0.217737328136915 3803 658348 SGTC_1982 st072467 71.9 µM -0.781120154026581 0.215950973381833 no 2662 0.217365914666867 3792 3163533 SGTC_111 0083-0039 52.457 µM -0.782006846034603 0.215690784661419 no 2663 0.217105275122966 3698 759313 SGTC_1509 1326-1131 80 µM -0.782560819072701 0.215528320461973 no 2664 0.21694252867067 3728 768313 SGTC_3048 9093155 49.47 µM -0.784058601606426 0.21508941987248 no 2665 0.216502862664413 3726 25236002 SGTC_502 l-744,832 89.3 µM -0.784071480804502 0.215085648086439 no 2666 0.216499084282208 3770 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.  SGTC_1739 st037196 92.5 µM -0.784129447289382 0.215068672568644 no 2667 0.216482079073452 3825 612214 SGTC_2928 9011484 9.79 µM -0.7843083936485 0.215016272934036 no 2668 0.216429587749396 3834 2994751 SGTC_1811 st050069 61.5 µM -0.784814115904428 0.214868225842353 no 2669 0.216281281276024 3757 3877702 SGTC_1748 st037455 53.6035 µM -0.785824944825341 0.214572489395102 no 2670 0.215985025243527 3814 580690 SGTC_2657 nystatin 74.44 µM -0.786850159901774 0.214272785841902 no 2671 0.215684793163048 3839 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_33 0986-0033 35.816 µM -0.787102803681909 0.214198967302233 no 2672 0.215610844139321 3722 2848082 SGTC_2506 ethyl hematommate 54.16 µM -0.789926974703136 0.213374796639244 no 2673 0.214785208441396 3904 3940691 An allergen. SGTC_649 1123-0311 367 µM -0.790778482105133 0.213126666581705 no 2674 0.214536634356176 3785 693629 YIL048W NEO1 SGTC_1207 2099-0101 141 µM -0.791228932541253 0.212995472997769 no 2675 0.214405205448102 3851 5837381 SGTC_2358 9037157 4 µM -0.791577385273226 0.212894018553091 no 2676 0.214303568760018 3837 2388925 SGTC_1167 k781-0610 148 µM -0.792696200291638 0.212568458468806 no 2677 0.213977422319991 3832 4525169 SGTC_2451 5856223 45.7 µM -0.795368724466553 0.21179196786997 no 2678 0.213199523651269 3806 2179896 SGTC_2536 dehydroabietamide 32.04 µM -0.795851047754335 0.211652007885605 no 2679 0.213059308431179 3864 3983547 SGTC_1169 aniline yellow 25.8 µM -0.796075805604382 0.211586806422439 no 2680 0.212993987914478 3770 6051 A DNA damaging agent. SGTC_1718 roemerine 11.9335 µM -0.800015016994704 0.210445965379503 no 2681 0.211851048313015 3693 235224 An aporphine alkaloid with mutagenic activity. SGTC_1713 st033146 12.748 µM -0.800502262132859 0.210305104930278 no 2682 0.211709926720313 3796 674619 SGTC_2594 a-mangostin 100 µM -0.800636507819977 0.210266304816465 no 2683 0.211671054595671 3867 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis. SGTC_1174 0739-0097 51.1 µM -0.802466020358066 0.209737952450733 no 2684 0.21114171825199 3842 728447 SGTC_1576 erythromycin ethylsuccinate 23.2 µM -0.802900614200871 0.209612559161803 no 2685 0.21101609050938 3840 3256 An antibiotic and ribosome inhibitor. SGTC_3111 9122088 49.47 µM -0.804777393383335 0.209071558939946 no 2686 0.210474074667997 3717 16876704 SGTC_2126 5251174 33.877 µM -0.807539390370211 0.208276883138032 no 2687 0.209677894961607 3842 790722 SGTC_3082 9117008 49.47 µM -0.807896766821591 0.208174189923759 no 2688 0.209575006353373 3918 41448529 SGTC_1402 3909-7673 35.9 µM -0.80800873230273 0.208142022449045 no 2689 0.209542777624251 3845 5328014 SGTC_1994 st072947 40.9 µM -0.80815141309097 0.208101034774819 no 2690 0.209501711865676 3908 5286565 YDL195W SEC31 SGTC_405 ebelactone b 50 µM -0.808522370807073 0.207994492660637 no 2691 0.209394966602005 3821 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).  SGTC_783 0848-0141 92.7 µM -0.808541651258874 0.207988956036417 no 2692 0.209389419413726 3817 6755076 YHR007C | YLR033W ERG11 | RSC58 SGTC_972 1319-0219 195 µM -0.808612907649851 0.207968494622583 no 2693 0.209368918952774 3833 23903702 SGTC_2546 rhodinyl acetate 100 µM -0.809043242756378 0.207844948307514 no 2694 0.209245136667418 3770 6708682 SGTC_57 miconazole 162.5 nM -0.809139926533978 0.207817197009321 no 2695 0.209217332316986 3780 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_458 nppb 133 µM -0.809178657328549 0.2078060806618 no 2696 0.209206194713373 3841 4549 A chloride channel blocker. SGTC_1774 st048371 48.465 µM -0.810587095853492 0.207402075286962 no 2697 0.20880141490264 3822 4242727 SGTC_1429 4049-0205 9.46 µM -0.81083612144508 0.207330691555905 no 2698 0.208729893948021 3857 22774478 SGTC_861 0443-0273 110 µM -0.811556888527289 0.207124163980329 no 2699 0.208522968699171 3878 6149169 SGTC_20 0481-0013 4.944 µM -0.812437681845763 0.206871948011876 no 2700 0.208270265756349 3872 182045 SGTC_747 3448-8087 38.7 µM -0.815748652091873 0.20592547605227 no 2701 0.207321953320511 3882 5168703 SGTC_492 tmb-8 126 µM -0.816088137849459 0.205828576260418 no 2702 0.207224863935753 3781 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1 SGTC_2571 chrysanthemic acid 100 µM -0.816662998907932 0.205664554743562 no 2703 0.207060521002334 3886 2743 An insecticide. SGTC_2625 euphol 100 µM -0.817365391551758 0.205464250776596 no 2704 0.206859823676461 3867 6708538 A triterpene alcohol. SGTC_625 k213-0058 121 µM -0.817742348762431 0.205356800247753 no 2705 0.20675216175279 3911 3655420 SGTC_1441 4106-0040 13 µM -0.817767411785667 0.205349657291246 no 2706 0.206745004733982 3835 2904180 SGTC_2182 6325192 200 µM -0.817906978650544 0.205309883462345 no 2707 0.206705152580952 3777 736248 SGTC_1411 3909-8223 150 µM -0.818200220679012 0.205226330125118 no 2708 0.206621434588045 3851 X1411 SGTC_158 k038-0087 26.446 µM -0.818688451879479 0.205087263426622 no 2709 0.206482093477051 3796 X158 SGTC_3295 9122362 53.5725 µM -0.819372464943001 0.204892524880449 no 2710 0.206286969910864 3912 4730473 SGTC_2742 clothiapine 36.27 µM -0.820614608714393 0.204539167748224 no 2711 0.205932911904579 3796 16351 An atypical antipsychotic. YIL048W NEO1 SGTC_2586 curcumin 80 µM -0.821461802555916 0.204298371600124 no 2712 0.205691636481685 3872 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40 SGTC_292 k038-0015 474 µM -0.821680322068572 0.204236289645515 no 2713 0.205629430741945 3845 46368540 SGTC_2910 7948405 25.97 µM -0.82224990329691 0.204074522969001 no 2714 0.205467341097515 3747 2971328 SGTC_1533 dihydroergotamine mesylate 29.4 µM -0.822396706587223 0.204032841763988 no 2715 0.205425576577022 3932 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release. SGTC_1099 5-nonyloxytryptamine 2.85 µM -0.824750245155519 0.203365304729501 no 2716 0.204756699698035 3835 23581825 A 5-HT1D beta serotonin receptor agonist. SGTC_1295 1013-0063 9.78 µM -0.826277023493803 0.20293296044494 no 2717 0.204323482077866 3838 6826038 SGTC_3203 9113543 49.47 µM -0.827246921590338 0.202658595657815 no 2718 0.204048560802405 3966 17018012 SGTC_1501 4491-0275 38.4 µM -0.828193309563482 0.20239109522226 no 2719 0.2037805161005 3814 5104718 SGTC_1734 st037168 69.4 µM -0.828611177480316 0.202273050373083 no 2720 0.203662230538234 3943 708907 SGTC_3100 9120536 49.47 µM -0.829472578601449 0.202029840393516 no 2721 0.203418523579801 3703 16421196 SGTC_2255 7941087 197.44 µM -0.82983449129984 0.201927709362864 no 2722 0.203316183437982 3895 935561 SGTC_2186 6124449 200 µM -0.830606488916253 0.201709956504255 no 2723 0.2030979839143 3863 3834182 YLR033W RSC58 SGTC_1041 0206-0046 107 µM -0.830863970598687 0.201637361437129 no 2724 0.203025239688217 3895 50494 SGTC_2566 crystal violet carbinol 226 nM -0.831724116737532 0.201394963051199 no 2725 0.202782342352464 3924 68050 Cationic dye that binds acidic phospholipids including cardiolipin. SGTC_511 blebbistatin 171 µM -0.832760469399158 0.201103139880691 no 2726 0.202489916655268 3953 3476986 A myosin inhibitor. SGTC_2807 7945238 51.95 µM -0.833099111293518 0.201007837813672 no 2727 0.202394417381997 3941 17148797 SGTC_2054 5233173 129 µM -0.833146180383808 0.200994593571509 no 2728 0.202381145716834 3914 6889 SGTC_1089 terbinafine 2.25 µM -0.833375436628425 0.200930093218882 no 2729 0.202316511752989 3891 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_699 0375-0592 111 µM -0.8338247192842 0.200803725313224 no 2730 0.202189881793088 3912 762578 SGTC_4 0960-0234 25.671 µM -0.835450486575077 0.200346851086173 no 2731 0.201732056968632 3883 6821112 SGTC_3211 9128781 49.47 µM -0.835707905125047 0.200274568462116 no 2732 0.201659623495476 3941 17194361 SGTC_694 1315-0438 43.2 µM -0.836544654317099 0.200039719204204 no 2733 0.20142428326539 3849 6793154 SGTC_1856 st057054 55.7 µM -0.837105267307067 0.199882465380775 no 2734 0.201266699956247 3874 1266018 SGTC_2879 9041815 71.43 µM -0.839477088858622 0.199217984538679 no 2735 0.200600820356151 3893 4942971 SGTC_1708 st033234 31.827 µM -0.840094370048295 0.199045267734119 no 2736 0.20042773825009 3982 674664 SGTC_3050 9093513 49.47 µM -0.841743391728634 0.198584310044694 no 2737 0.199965802126203 3883 25236664 SGTC_2616 abietic acid 100 µM -0.842081954146384 0.198489750053677 no 2738 0.199871040791768 3893 6708678 Abietic acid is an inhibitor of 5α-reductase. SGTC_2650 prasterone 100 µM -0.843540917127045 0.198082574654796 no 2739 0.199462995956718 3854 16759247 A steroid and weak partial agonist of the androgen receptor. SGTC_2185 6113692 200 µM -0.844648793555416 0.197773719587588 no 2740 0.199153478738164 3899 874150 SGTC_3127 9126946 49.47 µM -0.845136162483023 0.197637942528715 no 2741 0.199017409861704 3890 27243249 SGTC_2713 st079149 53.4 µM -0.846025740149448 0.197390258672856 no 2742 0.198769192529291 3930 3103253 SGTC_1261 0712-0010 12.7 µM -0.846241853830492 0.197330114799143 no 2743 0.198708918890807 3885 2840123 SGTC_1923 st058458 19.1 µM -0.847254023766642 0.197048578099168 no 2744 0.198426773593865 3916 3534982 SGTC_1180 1193-0155 285 µM -0.847935517788993 0.196859156454937 no 2745 0.198236941399683 3945 2921347 SGTC_1103 duloxetine 36.1 µM -0.848265774837806 0.19676740099766 no 2746 0.198144986760837 3996 60835 A selective serotonin reuptake inhibitor. SGTC_1806 st050005 60.3 µM -0.848288227614985 0.196761163873368 no 2747 0.198138736089681 3917 5194765 SGTC_886 0866-0150 153 µM -0.853504343953982 0.195315433211495 no 2748 0.196689839871105 3969 271463 SGTC_2994 9053520 71.4286 µM -0.854511949944523 0.195036904581968 no 2749 0.19641069553336 3971 4647384 SGTC_2434 5670830 169.91 µM -0.856441144049682 0.194504299096625 no 2750 0.195876907405148 3952 1549830 SGTC_730 1436-0052 41.2 µM -0.856552078516017 0.194473699617811 no 2751 0.195846239769728 3918 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2 SGTC_2789 5281112 71.43 µM -0.857095576749611 0.194323826766499 no 2752 0.195696032763502 3950 765948 SGTC_2046 4110841 106 µM -0.857224187294388 0.194288371940968 no 2753 0.195660498807724 3931 44119630 YMR134W ERG29 SGTC_968 1309-0633 340 µM -0.857333038178965 0.194258367455207 no 2754 0.195630427332035 3946 3761976 SGTC_558 k064-0027 21.3 µM -0.859754603663903 0.193591598595017 no 2755 0.194962164096593 3945 5088526 SGTC_2149 5554786 194.827 µM -0.860669763751804 0.193339976589189 no 2756 0.19470997530837 3949 745063 YPR165W RHO1 SGTC_2254 7938975 95.19 µM -0.860915675174453 0.193272397614626 no 2757 0.19464224384535 3976 2969277 SGTC_869 0564-0080 44.1 µM -0.864137618851855 0.192388306878982 no 2758 0.193756147815477 3941 6843321 SGTC_1194 1488-0194 225 µM -0.865569108529049 0.191996305523567 no 2759 0.193363251130871 3881 1391452 SGTC_1119 parthenolide 318.541 nM -0.867557318413715 0.19145266267771 no 2760 0.192818360290485 4055 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs. SGTC_1562 morin hydrate 59.1 µM -0.86815558044042 0.191289262687476 no 2761 0.192654583759211 4014 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase. SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM -0.868314989391148 0.191245738631563 no 2762 0.192610959293683 3990 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W SGTC_2574 2',4'-dihydroxychalcone 14.64 µM -0.868442796318675 0.19121084738605 no 2763 0.192575987520266 3936 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_1063 disulfiram 1.84 µM -0.869270392361206 0.190985008426032 no 2764 0.192349626596543 3916 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_2357 9067248 200 µM -0.870144576206971 0.190746634091476 no 2765 0.192110699944811 3942 9150235 SGTC_1782 st039423 80.636 µM -0.872049508332623 0.190227825882466 no 2766 0.19159068473585 3962 2068169 SGTC_1523 st012844 44.7 µM -0.872224154646622 0.190180304386964 no 2767 0.191543052345183 4071 4274103 SGTC_3064 1327-0027 10 µM -0.873659459192527 0.189790032462067 no 2768 0.191151867546191 3825 16000455 YPR107C YTH1 SGTC_2052 5265182 7.135 µM -0.874528414322003 0.189553995442911 no 2769 0.190915276562382 3951 1239884 SGTC_2522 biochanin a 4.94 µM -0.874535195758066 0.189552154090622 no 2770 0.190913430883041 3946 5280373 A possible chelator. SGTC_2638 epoxomicin 18 µM -0.874740588187787 0.189496389433262 no 2771 0.190857535142139 3941 9915668 A protesome inhibitor. SGTC_2944 9067346 25.62 µM -0.877822258895148 0.188660919074498 no 2772 0.1900200914948 3883 6473075 SGTC_2012 4023501 200 µM -0.87857682443874 0.188456695737455 no 2773 0.189815383123242 3968 3477460 SGTC_1886 st057356 49.9 µM -0.880483250091764 0.187941328888677 no 2774 0.189298787570851 3904 24207747 SGTC_1314 1222-0010 41.1 µM -0.883620569380263 0.187095109183774 no 2775 0.188450535729427 3953 3526027 SGTC_1467 k284-1082 293 µM -0.885939325364005 0.186471195207749 no 2776 0.187825111774631 3899 3334705 SGTC_147 4466-0538 29.23 µM -0.887123657210099 0.186153021592198 no 2777 0.187506164290286 4014 6742687 YHR072W ERG7 SGTC_3114 9122766 49.47 µM -0.887651120696456 0.186011425615054 no 2778 0.187364223085923 3950 17176985 SGTC_782 0083-0095 30.5 µM -0.88854090784964 0.185772716323333 no 2779 0.187124930628534 3926 3591729 An indicator and reagent. SGTC_1855 st056195 39.6 µM -0.891644270515589 0.184941644047363 no 2780 0.186291816611239 3901 4028379 SGTC_2377 9073351 62.6 µM -0.893082820402488 0.184557189111013 no 2781 0.185906411135894 3931 7337946 YHR072W ERG7 SGTC_1972 st070201 17.4 µM -0.893867690076728 0.184347641057462 no 2782 0.185696343379184 3938 2829099 SGTC_2327 6189656 200 µM -0.894543993258725 0.184167197359467 no 2783 0.185515451248793 4055 5349088 SGTC_356 1634-0012 32.5 µM -0.894741325319166 0.184114568137168 no 2784 0.185462691075189 3960 735457 SGTC_262 fenpropimorph 62.5 µM -0.894803058659329 0.184098105539766 no 2785 0.18544618750103 3923 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_205 1486-1330 71.903 µM -0.896826691152175 0.183558965396822 no 2786 0.184905701505094 3963 4118834 SGTC_585 0kpi-0023 191 µM -0.898169948435647 0.183201636094191 no 2787 0.1845474760371 3885 64601 SGTC_97 0535-0701 19.132 µM -0.898237583584361 0.183183655473092 no 2788 0.184529450233523 3885 2832013 YGL099W LSG1 SGTC_1504 k297-0033 30 µM -0.898411936902352 0.183137309191928 no 2789 0.18448298745256 3888 4388117 SGTC_1030 k029-0042 36.7 µM -0.898597279242418 0.183088049850084 no 2790 0.184433604226996 3964 6080581 SGTC_275 trichlorophene 5.69 µM -0.900904130608388 0.182475638499559 no 2791 0.183819647414481 4005 62616 SGTC_577 r071-0003 38.6 µM -0.901289669093463 0.182373412610581 no 2792 0.183717162596149 4003 4568517 YMR134W ERG29 SGTC_2155 5570423 76 µM -0.901483222164771 0.182322105326463 no 2793 0.183665725251949 3908 797402 SGTC_1445 4239-0156 97.7 µM -0.901536610561471 0.18230795465237 no 2794 0.183651538694834 4076 4008346 SGTC_506 n9-isopropylolomoucine 153 µM -0.906550865031986 0.180981979230153 no 2795 0.182322177548259 3988 6610355 SGTC_2447 5741742 33.78 µM -0.907236018066449 0.180801266995669 no 2796 0.18214100029942 4037 1776504 SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM -0.907771683749251 0.180660061546482 no 2797 0.181999430895297 4042 6710655 SGTC_1878 temozolomide 1 mM -0.908665256023259 0.180424663205212 no 2798 0.181763424645603 3871 5394 DNA alkylating agent. SGTC_2237 6667747 47.222 µM -0.909099409496741 0.180310361412066 no 2799 0.181648827142611 3972 729940 YDL015C TSC13 SGTC_2289 7946404 165.07 µM -0.909947302091197 0.18008726347664 no 2800 0.181425151033379 4019 1246120 YPR165W RHO1 SGTC_1732 st034308 51.822 µM -0.911214869771334 0.179754063764123 no 2801 0.181091085350514 3851 830119 SGTC_1912 st060209 90.8 µM -0.911642965589627 0.179641619722943 no 2802 0.18097834840664 4020 688787 SGTC_2948 9070189 9.45 µM -0.912140774652523 0.1795109203328 no 2803 0.18084730813811 3924 6473636 YDL196W YDL196W SGTC_1088 bifonazole 369 nM -0.91221913502563 0.179490352322654 no 2804 0.180826686442918 3930 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase. SGTC_1814 st052110 31.539 µM -0.912685097428615 0.179368077230119 no 2805 0.180704091964678 3919 674163 SGTC_3157 9099274 49.47 µM -0.91385407065789 0.179061552778139 no 2806 0.180396765110919 3977 17217662 SGTC_1360 1598-0022 39.8 µM -0.914691927487417 0.178842055502999 no 2807 0.180176691707712 4044 761525 SGTC_1851 st056236 18.9 µM -0.915266587375766 0.178691607119722 no 2808 0.180025847689482 3950 5393171 SGTC_199 4063-0024 41.6 µM -0.916648619391439 0.178330111699883 no 2809 0.179663399166505 4006 306215 SGTC_294 k038-0071 157 µM -0.917321776352463 0.178154202351522 no 2810 0.179487024756407 3988 24152826 SGTC_2998 9066762 71.4286 µM -0.918076957304224 0.177956988727393 no 2811 0.179289288759736 4021 4945196 SGTC_2541 muurolladie-3-one 83.07 µM -0.92206546694224 0.176917684344913 no 2812 0.178247214211487 4029 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils.  YMR203W TOM40 SGTC_2532 xanthone 78.9 µM -0.922080684442455 0.17691372641044 no 2813 0.178243245671824 4007 7020 An insecticide. SGTC_2756 carbadox 75.1 µM -0.926228310927177 0.175837052750624 no 2814 0.177163671332028 3990 2553 A substituted quinoxaline antibiotic. YLR208W SEC13 SGTC_718 1130-0073 349 µM -0.926734630820818 0.175705903061772 no 2815 0.17703216616054 4043 6740020 SGTC_928 2764-0428 58.7 µM -0.927189520095078 0.175588128072454 no 2816 0.176914071541788 4036 662578 SGTC_340 k038-0059 454 µM -0.929062695073419 0.175103673279647 no 2817 0.176428298010517 3987 23733424 SGTC_2454 5-benzylidenerhodanine 10.36 µM -0.930358324912663 0.174769084152095 no 2818 0.176092794352558 4078 1273210 SGTC_2663 amphotericin b 100 µM -0.930369350926433 0.174766238488665 no 2819 0.176089940897959 3978 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_1686 st019653 115.5 µM -0.932024630187961 0.174339367212618 no 2820 0.175661898374007 3977 97252 SGTC_650 1328-0195 38 µM -0.932059108631036 0.174330482796567 no 2821 0.175652989527844 3979 2780821 SGTC_2431 5490079 200 µM -0.933034194346066 0.174079341515115 no 2822 0.175401156768697 4063 5722345 SGTC_727 3032-0951 202 µM -0.93493582832387 0.173590222168663 no 2823 0.17491068573101 4025 3652836 SGTC_2345 9052315 157.45 µM -0.936091881817446 0.173293301442842 no 2824 0.174612941242914 4063 6469265 SGTC_279 1273-0055 2.93 µM -0.938588713217726 0.172653119537259 no 2825 0.173970974958595 4030 2847562 SGTC_1644 st010134 20.9 µM -0.940412906188997 0.172186355056013 no 2826 0.173502902305511 3977 3818134 SGTC_1796 st049173 110.4 µM -0.940752413807299 0.172099572676698 no 2827 0.173415876039382 3953 94134 SGTC_892 0929-0076 29 µM -0.940947644780273 0.172049681851002 no 2828 0.173365844909356 4003 5751038 SGTC_2157 5649910 96.377 µM -0.945784791860894 0.170816508967823 no 2829 0.172129182000426 4013 2858091 SGTC_1920 st075728 45.7 µM -0.946973770779726 0.170514261166471 no 2830 0.171826072309893 3968 3400306 SGTC_600 1495-0418 41.6 µM -0.94765240498685 0.170341900617447 no 2831 0.171653219109601 4012 5377768 SGTC_3061 glucosamine 200 µM -0.947771917044992 0.170311558324541 no 2832 0.171622790004109 3907 91431 and experimental redox chemotherapeutic SGTC_1196 1588-0294 184 µM -0.948399693866227 0.170152232206523 no 2833 0.171463007611875 4036 6144269 SGTC_2252 omeprazole 400 µM -0.9484523702073 0.170138867601295 no 2834 0.171449604700953 3977 4594 A proton pump inhibitor. SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM -0.948959982186713 0.170010114967336 no 2835 0.17132048277802 4036 7104 SGTC_920 mycophenolic acid 780.421 nM -0.949303894112392 0.169922919337708 no 2836 0.171233036788261 4042 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_1012 4112-3522 18 µM -0.949481590968991 0.169877877209581 no 2837 0.171187865249164 4056 3112398 SGTC_1254 0550-0035 264 µM -0.950607611989889 0.169592634356928 no 2838 0.170901801533966 4105 15121435 SGTC_2876 9059903 25.97 µM -0.95141466252816 0.169388382027422 no 2839 0.170696960002332 3976 6916095 SGTC_310 1273-0058 1.06 µM -0.952601073860613 0.169088405965074 no 2840 0.170396116466979 3913 2734232 SGTC_1022 4477-0945 21.3 µM -0.954426781820362 0.168627454950107 no 2841 0.169933827501098 3984 4648966 SGTC_1490 4089-0339 670 nM -0.954798251662846 0.168533765987404 no 2842 0.169839865860439 3968 742542 SGTC_973 1325-0077 65.9 µM -0.956409860048372 0.168127687467618 no 2843 0.169432602579528 4051 2835149 SGTC_2205 7238770 200 µM -0.956801903725688 0.168028999124984 no 2844 0.169333625597837 4099 279867 SGTC_2919 7978188 46.38 µM -0.958059315071208 0.167712725168464 no 2845 0.169016424746298 4043 2980291 SGTC_125 0133-0007 11.75 µM -0.958606806341873 0.167575135751735 no 2846 0.168878431208608 4114 26541 SGTC_344 k064-0035 6.43 µM -0.95949559926725 0.167351929074048 no 2847 0.168654567787678 4001 5088750 SGTC_3065 9113888 49.47 µM -0.95967855797595 0.167306005597952 no 2848 0.168608509013621 4124 16648368 SGTC_3162 9099653 49.47 µM -0.959774353941583 0.1672819636106 no 2849 0.168584396170616 4024 25237511 SGTC_2834 9001755 58.44 µM -0.962653316274815 0.16656046738984 no 2850 0.167860765868619 3970 2989575 SGTC_3216 9129716 49.47 µM -0.963238195513031 0.16641413675614 no 2851 0.167714000585546 4007 8056934 SGTC_1242 0402-0103 60.1 µM -0.963977146472885 0.166229377718369 no 2852 0.167528691872779 3974 432868 SGTC_2839 9003951 25.97 µM -0.964548867868032 0.166086521835316 no 2853 0.167385410305876 4105 2990634 SGTC_3329 9141233 27.5565 µM -0.965201442349706 0.165923560179555 no 2854 0.167221962335787 4026 4909101 YNL103W MET4 SGTC_1250 0485-0349 40.2 µM -0.965205081721568 0.16592265164126 no 2855 0.16722105108406 4057 6842794 YDL195W SEC31 SGTC_934 2950-0684 338 µM -0.965253966533151 0.165910448274627 no 2856 0.167208811268647 4093 1121253 SGTC_1872 amphotericin b 148 nM -0.966106995043023 0.165697595768142 no 2857 0.166995322326254 4062 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1 SGTC_3075 9116269 49.47 µM -0.966767458678321 0.165532914473134 no 2858 0.166830147729764 4077 17015205 YNL244C SUI1 SGTC_2967 9089538 49.85 µM -0.9667863559886 0.165528204139162 no 2859 0.166825423274477 4071 728216 SGTC_135 0933-0004 26.348 µM -0.96865052322515 0.165063968881245 no 2860 0.166359793110813 4040 21230617 YGL099W LSG1 SGTC_687 k029-0044 34.9 µM -0.968861328565329 0.165011524936119 no 2861 0.166307191192234 4137 5829338 SGTC_2340 7987427 183.45 µM -0.969266497318282 0.164910757750662 no 2862 0.166206120248146 4081 2239331 SGTC_595 3909-8003 73.7 µM -0.970310207263935 0.164651366253029 no 2863 0.165945945467094 4124 699517 SGTC_830 4076-0286 57.8 µM -0.971590538617671 0.164333528888693 no 2864 0.165627145659608 4126 6866659 SGTC_1757 st041620 31.8375 µM -0.971593465693901 0.164332802709262 no 2865 0.165626417277861 4124 5289815 SGTC_1400 3771-8998 51.5 µM -0.975881376405987 0.163271247395128 no 2866 0.164561626054738 3967 670767 SGTC_1916 st067606 49.2 µM -0.977528843820709 0.162864572365164 no 2867 0.164153702613371 4024 19590279 SGTC_2666 tannic acid 100 µM -0.981706274884573 0.161836334578421 no 2868 0.163122286592399 4072 16134267 A thiamine antagonist. SGTC_2518 prenyletin 46.28 µM -0.98221533185925 0.161711324456039 no 2869 0.162996887937513 4019 3873459 A coumarin with calcium channel inhibitory activity. SGTC_2362 9071156 126 µM -0.983569597423887 0.161379061303917 no 2870 0.162663589854644 4106 653133 SGTC_3083 9117465 49.47 µM -0.985455029826547 0.160917220634491 no 2871 0.162200305195695 4070 16420915 SGTC_1952 st077036 64.1 µM -0.985610998732128 0.160879054395521 no 2872 0.162162019342111 4095 2937007 SGTC_1882 5615643 20 µM -0.98869680659826 0.160125159559821 no 2873 0.161405752852133 4020 2253075 SGTC_1163 k060-0048 49.9 µM -0.992695442797939 0.159151692544177 no 2874 0.160429198234688 4074 6809982 SGTC_1758 st042942 75.2445 µM -0.994431601452757 0.15873023466751 no 2875 0.160006394743611 4011 669317 SGTC_1933 st074711 15.9 µM -0.997496325085755 0.157988050949957 no 2876 0.159261828346827 4054 17250958 SGTC_263 alizarin 107.927 µM -0.997657032573369 0.157949195409076 no 2877 0.159222847605302 4102 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM -1.0010471917668 0.157130991753064 no 2878 0.158401996854741 4130 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis. SGTC_179 1273-0063 6.77 µM -1.00430638913996 0.156347027898354 no 2879 0.157615477496292 4067 3108139 SGTC_1861 st057647 17.4 µM -1.00727139175579 0.155636071057564 no 2880 0.15690218681952 4178 688668 SGTC_1117 retinoic acid 1.10837 µM -1.00803857366798 0.155452461762835 no 2881 0.156717972265644 4145 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR). SGTC_770 0389-1121 67.2 µM -1.01027236134426 0.154918664588513 no 2882 0.156182409536128 4198 6753108 SGTC_3018 9082602 49.47 µM -1.01348993978445 0.154151906093219 no 2883 0.155413099493914 4063 17332089 SGTC_1615 st002656 86.5 µM -1.01548767441393 0.153677105273514 no 2884 0.154936709499823 4101 1584458 SGTC_3284 9108171 64.8615 µM -1.01604401004744 0.153545053743616 no 2885 0.154804214737687 4095 8687505 SGTC_2374 9071832 200 µM -1.01897367408529 0.152850910316797 no 2886 0.154107732430683 4012 17381698 SGTC_1329 1447-1697 50.6 µM -1.01957009639746 0.152709851629567 no 2887 0.153966196604592 4113 2840515 SGTC_102 gallobenzophenone 83.616 µM -1.02064644488761 0.152455505121226 no 2888 0.153710988172834 4122 70837 SGTC_3119 9125183 49.47 µM -1.02209328145906 0.152114053622479 no 2889 0.153368376365537 3928 22695334 SGTC_519 k048-0011 62.8 µM -1.02217824062249 0.152094019171685 no 2890 0.153348273720091 4148 6836379 SGTC_1081 sertraline 6 µM -1.02344344956309 0.151795874180777 no 2891 0.153049112383416 4107 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1 SGTC_2946 9065502 71.43 µM -1.02513143808423 0.151398706764798 no 2892 0.152650586693094 3922 16489101 SGTC_2843 9000894 45.46 µM -1.02514330049263 0.151395918101971 no 2893 0.152647788475627 4032 2242070 SGTC_655 k060-0012 42 µM -1.02528783961019 0.151361942006767 no 2894 0.152613695950186 4102 5994525 SGTC_2411 st077133 39.94 µM -1.02544277143661 0.151325528580166 no 2895 0.152577157700351 4188 1403142 YNL221C POP1 SGTC_1140 3229-1848 2.98 µM -1.02545453333796 0.151322764433677 no 2896 0.152574384076799 4144 2849525 SGTC_2796 7949634 45.45 µM -1.02582116048222 0.151236620784983 no 2897 0.152487944957199 4079 2971588 SGTC_3069 9117009 49.47 µM -1.02710181725464 0.150935970432833 no 2898 0.152186261532441 4087 41904981 SGTC_490 phenamil 164 µM -1.02780672513426 0.15077065426164 no 2899 0.152020376088181 4091 4755 Irreversibly blocks amiloride-sensitive Na+ channels. SGTC_2847 9005661 71.43 µM -1.02980263954231 0.150303223220611 no 2900 0.151551330712551 4113 2991449 SGTC_3059 1327-0034 3 µM -1.03010845189281 0.150231689234011 no 2901 0.151479549058117 4014 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_297 0986-0032 24 µM -1.03019937563195 0.150210425216866 no 2902 0.151458211388283 4060 2847425 SGTC_152 4469-0003 551.229 µM -1.03138414004866 0.149933531876088 no 2903 0.151180357643936 4020 697280 SGTC_624 k048-0052 28 µM -1.03422235295059 0.149271593418951 no 2904 0.150516113286882 4108 6835531 SGTC_2285 7945142 200 µM -1.03430908073296 0.149251397217809 no 2905 0.15049584650966 4180 2970608 SGTC_1791 st048313 56.1 µM -1.03858673899663 0.148257527972729 no 2906 0.14949848790137 4136 1204976 SGTC_374 0880-0231 82.3 µM -1.04147432590265 0.147589136112453 no 2907 0.148827731392819 4039 6833587 SGTC_702 1488-0190 94 µM -1.0423434273812 0.147388360356156 no 2908 0.148626242489283 4172 949357 SGTC_670 4204-0025 119 µM -1.04253975033907 0.147343032098961 no 2909 0.148580753046093 4136 719039 SGTC_417 st075190 100 µM -1.04585322247016 0.146579406649215 no 2910 0.147814402070264 4146 222757 SGTC_2545 solidagenone 89.61 µM -1.04728219689404 0.146250905249326 no 2911 0.14748472230689 3967 6708572 An anti ulcer agent SGTC_1781 st038725 66.3 µM -1.047725594616 0.146149074847164 no 2912 0.147382525910039 4118 4270275 YIL048W NEO1 SGTC_2361 9034121 116 µM -1.04877594002563 0.145908043342877 no 2913 0.14714062674006 4137 6496917 SGTC_384 k007-0144 5.16 µM -1.04991111560285 0.145647845677179 no 2914 0.146879490264877 4083 6824886 SGTC_418 lividomycin a 100 µM -1.04991691682771 0.145646516759342 no 2915 0.146878156546487 4165 72394 An antibiotic. SGTC_2068 5226020 147 µM -1.05038924660118 0.145538344985337 no 2916 0.146769593819541 4170 1810509 SGTC_2988 9073640 71.4286 µM -1.05132873829663 0.145323345604885 no 2917 0.146553816242954 4213 9102229 SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM -1.05232187932064 0.145096301198361 no 2918 0.146325948382135 4131 676296 Flavone; oxidizing agent. SGTC_2493 resveratrol 26.09 µM -1.05308475172196 0.144922061276439 no 2919 0.146151075360727 4068 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase. SGTC_977 1348-1378 135 µM -1.05413641135082 0.144682093444698 no 2920 0.145910233957893 4129 X977 SGTC_2150 5556613 200 µM -1.05680792225207 0.144073711791124 no 2921 0.145299628984586 4146 743190 SGTC_2057 5236571 38.335 µM -1.05708283280782 0.144011204604947 no 2922 0.145236892667829 4140 54684039 YBR257W POP4 SGTC_2595 hexamethylquercetagetin 100 µM -1.05850349117791 0.14368847701464 no 2923 0.144912979987577 4135 386331 SGTC_1661 st013063 9.66 µM -1.05970286259064 0.143416398881252 no 2924 0.144639900045552 4199 721395 SGTC_2275 7947463 200 µM -1.0598460214544 0.143383946458691 no 2925 0.144607327965479 4130 1225414 SGTC_450 aminopyrene 156 nM -1.06058258860451 0.143217053778857 no 2926 0.144439819366075 4075 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1 SGTC_3118 9124250 49.47 µM -1.06210494316293 0.142872531978562 no 2927 0.144094023142896 4082 1504786 SGTC_3155 9099265 49.47 µM -1.06248523250331 0.142786556774803 no 2928 0.144007729284848 4169 25236499 SGTC_316 k060-0003 58.6 µM -1.06404324185605 0.142434689713877 no 2929 0.143654555483654 4194 6152314 SGTC_2969 9091408 28.7 µM -1.0657908646867 0.142040698081067 no 2930 0.143259095706939 4107 4286311 SGTC_1379 2144-0755 36.5 µM -1.06605630276629 0.141980921171624 no 2931 0.143199095589736 4213 5392327 SGTC_2785 7756463 72.73 µM -1.06641191385665 0.141900863909785 no 2932 0.143118739203315 4119 2201551 SGTC_73 0327-0325 16.231 µM -1.06887871583418 0.141346364392591 no 2933 0.142562161890544 4028 53298 SGTC_816 0325-0417 81.3 µM -1.07084191470988 0.140906118056281 no 2934 0.142120258429548 4178 68101 SGTC_3262 9137218 49.47 µM -1.07235667525564 0.140567070177911 no 2935 0.141779929834703 4058 17650664 SGTC_1258 0671-0043 57.1 µM -1.07389883131513 0.140222459705499 no 2936 0.141434013600081 4184 4298767 SGTC_100 0086-0128 49.5915 µM -1.07495099794012 0.139987671946038 no 2937 0.141198333872963 4197 93297 SGTC_1481 3346-2004 36 µM -1.07836510727632 0.139227664454164 no 2938 0.140435426068022 4244 2770522 SGTC_705 1124-0212 310 µM -1.07891579879284 0.139105339682202 no 2939 0.140312632621568 4156 9554485 SGTC_2248 tofa 1.1 µM -1.08006985593551 0.138849227014166 no 2940 0.140055537007036 4134 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_815 1582-0027 36.9 µM -1.08065243482505 0.138720060972117 no 2941 0.139925874370224 4206 3128206 SGTC_3073 9114972 49.47 µM -1.08124571231414 0.138588607036183 no 2942 0.139793914448904 4176 41905075 SGTC_1284 0929-0043 16 µM -1.08175699974774 0.138475387943937 no 2943 0.139680259078675 4178 1239883 SGTC_611 3453-1652 23.7 µM -1.08183383706114 0.138458378598382 no 2944 0.139663184150878 4207 1560575 SGTC_1965 Pectolinarigenin 58.4 µM -1.08212582705513 0.138393754255538 no 2945 0.139598310546845 4140 5320438 An anti-inflammatory. SGTC_1115 galangin 695.678 nM -1.08257648389762 0.138294053513701 no 2946 0.13949822496636 4239 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_2212 7123476 200 µM -1.0836350045586 0.138060065062093 no 2947 0.139263331974235 4149 1085715 SGTC_1926 methyl fluorone black 53.6 µM -1.08744460049496 0.137220180316986 no 2948 0.138420184694089 3873 72721 Reacts with homocysteine. SGTC_1493 4348-0038 111 µM -1.08768111587567 0.137168152127108 no 2949 0.138367953587843 4152 800424 SGTC_1143 3454-2408 5.08 µM -1.08903374801879 0.13687086168213 no 2950 0.138069501849302 4176 X1143 SGTC_3126 9127922 49.47 µM -1.08952380505779 0.136763262462978 no 2951 0.137961481553603 4230 45595682 SGTC_1259 0671-0132 43 µM -1.09053820151339 0.136540720598986 no 2952 0.137738067504928 4117 X1259 SGTC_1026 k007-1105 30.6 µM -1.09090235316167 0.136460892172759 no 2953 0.137657925790077 4169 7066794 SGTC_979 1426-2828 121 µM -1.09254113822352 0.136102036897848 no 2954 0.137297659398794 4284 747872 SGTC_1958 st076513 41.9 µM -1.09578938898524 0.135392656975187 no 2955 0.136585476581217 4146 732122 YGL099W LSG1 SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM -1.09870690443541 0.134757669528199 no 2956 0.135947964995058 4166 16623 A steroid. SGTC_900 1112-0045 141 µM -1.09885175095511 0.13472619750213 no 2957 0.135916367490161 4068 56211 YIL048W NEO1 SGTC_3034 9090421 49.47 µM -1.10144569179762 0.13416344393662 no 2958 0.135351364241883 4093 17173761 SGTC_1230 0170-0365 3.77 µM -1.10262242946032 0.133908684715994 no 2959 0.135095582850492 4252 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1 SGTC_838 0109-0203 71.4 µM -1.10300402298942 0.133826142602515 no 2960 0.135012709052519 4207 759422 SGTC_1171 0368-0077 21.4 µM -1.1033897919922 0.133742732851473 no 2961 0.13492896388132 4151 3239779 SGTC_540 1187-0821 17.3 µM -1.10404000476828 0.133602226803872 no 2962 0.134787892242325 4141 847520 SGTC_1983 st071813 46.9 µM -1.10483422692802 0.133430739178371 no 2963 0.134615713347687 4261 11838595 SGTC_835 0312-0010 67.2 µM -1.10572258617857 0.133239105030152 no 2964 0.134423305462882 4186 1626196 SGTC_925 2064-1272 59.6 µM -1.10802568251085 0.132743170344973 no 2965 0.133925362235191 4179 6815817 SGTC_1999 st074831 12.5 µM -1.10853956988211 0.132632686687716 no 2966 0.133814429902622 4172 17112523 SGTC_992 3909-8734 162 µM -1.10918395168515 0.132494236806809 no 2967 0.133675417149111 4224 4288319 SGTC_1948 st076329 66.6 µM -1.11055989029211 0.132198940319218 no 2968 0.133378917793521 4081 24208413 SGTC_634 1611-4317 11.2 µM -1.11120215761631 0.132061255831275 no 2969 0.133240671371996 4243 2843522 SGTC_1750 st081859 2.357 µM -1.11229593750372 0.131827007101004 no 2970 0.133005465009024 4153 5291695 SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM -1.1147655115936 0.131299166936606 no 2971 0.132475459621295 4180 689007 SGTC_466 geldanamycin 89.2 µM -1.1181586366198 0.130576312485863 no 2972 0.131749623387595 4153 5288382 HSP90 inhibitor. SGTC_905 2-aminofluorene 215 µM -1.12077663797201 0.130020470484184 no 2973 0.131191475417503 4225 1539 An established DNA mutagen. YPR165W RHO1 SGTC_2278 7948257 134.34 µM -1.12230712816056 0.12969628349312 no 2974 0.130865938217132 4219 1247028 SGTC_2739 tacrine 100.86 µM -1.12312342264428 0.129523605870422 no 2975 0.130692539813853 4265 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders. SGTC_2379 9035213 200 µM -1.12369205742559 0.129403411945095 no 2976 0.130571843527196 4219 646551 SGTC_2315 7733312 200 µM -1.1243399079715 0.12926656817798 no 2977 0.130434427153958 4113 726316 SGTC_1416 3966-0321 25.3 µM -1.12434890993325 0.129264667424087 no 2978 0.130432518441675 4262 582530 YLR208W SEC13 SGTC_2346 9031566 143.75 µM -1.1272898815269 0.128644721412849 no 2979 0.129809969536954 4205 4771086 SGTC_3260 9137109 49.47 µM -1.12986981214882 0.128102582849857 no 2980 0.129265542956844 4166 17478346 SGTC_671 0560-0003 407 µM -1.13269811113768 0.127510078708709 no 2981 0.128670525582893 4139 3238678 SGTC_862 0452-0056 10.2 µM -1.13311899963474 0.127422069365875 no 2982 0.128582141798576 4179 1575396 YLR359W | YHR072W ADE13 | ERG7 SGTC_2213 7173844 200 µM -1.13679344490368 0.126655523452479 no 2983 0.127812322147004 4201 892728 SGTC_2207 7258803 200 µM -1.13967510663292 0.12605661558047 no 2984 0.127210840915654 4220 3666799 SGTC_1004 4084-0029 199 µM -1.14134809766667 0.125709818116018 no 2985 0.126862547077456 4252 716894 YLR208W SEC13 SGTC_2129 girgensonine 121.053 µM -1.14592028284617 0.124765438309236 no 2986 0.12591406899505 4246 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_1218 1348-1416 30.7 µM -1.14597667404294 0.124753821803969 no 2987 0.125902401864075 4195 6787668 SGTC_737 1950-0117 57.9 µM -1.1487929950926 0.124174625010486 no 2988 0.125320674255317 4229 5393513 SGTC_1291 0993-0025 5.79 µM -1.15009807269089 0.123906865192681 no 2989 0.125051740052044 4226 4353356 SGTC_2166 5933061 31.504 µM -1.15287068600483 0.123339356287299 no 2990 0.124481732834954 4384 2877375 SGTC_1496 4469-0713 57.4 µM -1.15319633079722 0.123272821787055 no 2991 0.124414904609642 4219 746691 SGTC_3071 9117417 49.47 µM -1.15323787772576 0.123264334886659 no 2992 0.124406380230277 4195 45595590 YGL055W OLE1 SGTC_2231 micatex 6.853 µM -1.1532857521109 0.123254555967773 no 2993 0.12439655812325 4254 20737 An antifungal of unknown mechanism. SGTC_2633 5,7-dihydroxyisoflavone 100 µM -1.15979156636647 0.121930718501532 no 2994 0.123066839305155 4262 5377381 SGTC_1166 k206-0078 225 µM -1.16216015451585 0.1214512346817 no 2995 0.122585208231846 4273 5404595 SGTC_2597 laccaic acid a 100 µM -1.1624094569521 0.121400844491696 no 2996 0.122534591851523 4246 5491415 A textile dye. SGTC_627 1391-0720 175 µM -1.16355555622386 0.121169378597872 no 2997 0.122302085661396 4222 997839 SGTC_3189 9110682 49.47 µM -1.16677179367822 0.120521486530653 no 2998 0.121651270358467 4311 17122418 SGTC_326 k292-0812 17.5 µM -1.16737967286949 0.120399307473148 no 2999 0.121528538157674 4245 3579357 SGTC_2687 chenodiol 100 µM -1.16812123928836 0.120250376470014 no 3000 0.121378932087234 4328 5702181 A cholesterol synthesis inhibitor. SGTC_1939 st074455 53.6 µM -1.16920623965601 0.120032706550457 no 3001 0.121160273921877 4259 1644229 SGTC_2229 7354935 190 µM -1.16973187200401 0.119927355486026 no 3002 0.121054443867712 4198 318112 SGTC_366 0181-0206 4.31 µM -1.17050294303743 0.119772929782624 no 3003 0.120899315244012 4277 274874 SGTC_893 0958-0369 48.9 µM -1.17130805284811 0.11961183667976 no 3004 0.120737487847574 4168 6819948 SGTC_1689 st020265 53.493 µM -1.1723177785333 0.119410018422894 no 3005 0.120534748185716 4272 5758320 YPR016C TIF6 SGTC_1370 2001-0092 44.6 µM -1.17237523577913 0.119398541423239 no 3006 0.120523218738146 4296 790957 SGTC_796 1234-0020 70.7 µM -1.17307919015478 0.11925799076448 no 3007 0.120382025354875 4200 46495034 SGTC_2550 chrysin dimethyl ether 71.87 µM -1.17565349643451 0.118745002418867 no 3008 0.119866684369946 4103 88881 An O-methylated flavonoid and antioxidant. SGTC_1160 4092-0570 10.5 µM -1.17592071806127 0.118691841948603 no 3009 0.119813279486931 4253 4994975 SGTC_2551 apiole 73.87 µM -1.17658381930307 0.118559998713424 no 3010 0.119680829587673 4168 10659 A possible DNA adduct former. SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM -1.17891017388813 0.118098272348271 no 3011 0.119216973046607 4241 442882 SGTC_2526 patulin 37.61 µM -1.18629339766377 0.116641304879321 no 3012 0.117753226539943 4304 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.  SGTC_588 3970-1144 52.9 µM -1.1892349093507 0.116064407253848 no 3013 0.117173620471682 4149 1888707 SGTC_2667 digitoxin 100 µM -1.19018526858263 0.115878453715089 no 3014 0.116986790962288 4205 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_2335 9018011 154.17 µM -1.19071050609074 0.115775773102644 no 3015 0.11688362603514 4270 6458208 SGTC_3251 9135047 49.47 µM -1.19233445117709 0.115458710902681 no 3016 0.116565065566736 4304 17682963 SGTC_1541 2',3',6-trimethoxyflavone 64 µM -1.19249600052336 0.115427203469728 no 3017 0.116533409016759 4376 688801 SGTC_1390 3413-2614 145 µM -1.19577046483326 0.114789891943818 no 3018 0.115893072315588 4297 3421432 SGTC_442 cape 100 µM -1.19627570227948 0.114691780555421 no 3019 0.115794493698538 4287 5281787 SGTC_2684 capsaicin 100 µM -1.19747492441353 0.11445914414126 no 3020 0.115560747795986 4308 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_137 0438-0332 85.389 µM -1.19964879428628 0.114038293118509 no 3021 0.11513788384554 4241 2063393 YER012W | YPR107C PRE1 | YTH1 SGTC_1683 st010134 710 nM -1.19982352085553 0.114004514798753 no 3022 0.11510394363938 4264 3818134 SGTC_1510 1123-0200 71.5 µM -1.19997619119933 0.113975006246832 no 3023 0.11507429362483 4308 5378812 YNL149C | YNL150W PGA2 | YNL150W SGTC_1406 3909-7906 11.9 µM -1.20103975128011 0.113769589369468 no 3024 0.11486789096515 4300 X1406 SGTC_1522 st012842 45.6 µM -1.20232050700584 0.113522573519351 no 3025 0.114619687328645 4130 3491067 YOR116C RPO31 SGTC_225 nsc-122657 1.016 µM -1.20286335769729 0.113417990871783 no 3026 0.114514601008733 4290 275685 SGTC_2808 7946468 45.46 µM -1.20338708156163 0.113317158235356 no 3027 0.114413282318924 4269 2970879 SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM -1.20403236614533 0.113193009444917 no 3028 0.114288534486459 4318 5393153 SGTC_825 1988-2224 89.6 µM -1.20413886285492 0.113172529465175 no 3029 0.114267955623639 4273 1180859 SGTC_2488 5268135 45.7 µM -1.20474574902773 0.113055871939282 no 3030 0.114150734500929 4339 1270356 YLR208W SEC13 SGTC_2130 NSC 7 2.4545 µM -1.2056329775869 0.112885480610508 no 3031 0.113979518930786 4360 21448 SGTC_1064 honokiol 6.76 µM -1.20681998686751 0.112657803513828 no 3032 0.113750738541786 4317 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis. SGTC_3027 9089541 49.47 µM -1.20688413495552 0.11264550878617 no 3033 0.113738384172314 4289 9943819 SGTC_2902 5787006 60.46 µM -1.20718594131031 0.112587676945357 no 3034 0.113680271701817 4235 591003 SGTC_1253 0550-0034 176 µM -1.21471098904651 0.111152585118538 no 3035 0.112238169907456 4330 5969915 SGTC_1583 clindamycin 39.6 µM -1.22022331626164 0.110109680729858 no 3036 0.111190115144232 4263 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis. SGTC_3058 9093861 49.47 µM -1.22870584287245 0.108518572773355 no 3037 0.109591057369069 4323 17217477 SGTC_2517 totarol 10 µM -1.23042957616086 0.108197276166825 no 3038 0.109268141801552 4309 460178 An antibacterial membrane disruptor. YGL001C ERG26 SGTC_2886 9058944 51.95 µM -1.2342304670867 0.107491227010739 no 3039 0.108558518753867 4206 4949929 SGTC_475 α-linolenic acid 10 µM -1.23864790941582 0.106674827375982 no 3040 0.107737958689349 4328 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_3330 9141424 71.43 µM -1.23998641939298 0.10642833939028 no 3041 0.10749020865627 4362 27261020 SGTC_2108 5365811 200 µM -1.24075902858863 0.106286249945585 no 3042 0.107347390443046 4335 780283 SGTC_2183 6420625 130.508 µM -1.24125541736228 0.106195032120109 no 3043 0.10725570428257 4332 2897619 SGTC_85 0868-0259 160.055 µM -1.24154867723048 0.106141168425264 no 3044 0.107201563860213 4229 83173 SGTC_1980 st071811 45.7 µM -1.24276771995334 0.105917475668609 no 3045 0.106976720455335 4394 4974850 SGTC_1038 k292-0204 154 µM -1.24308462095884 0.105859380582368 no 3046 0.106918326161539 4264 4454212 SGTC_2626 ethyl orsellinate 100 µM -1.24527846905164 0.105457830376065 no 3047 0.10651470362767 4281 75653 A natural product. SGTC_3246 9135460 32.98 µM -1.2478427212876 0.104989881166659 no 3048 0.106044330085789 4299 41446951 SGTC_3235 9132602 49.47 µM -1.25058229513368 0.104491600341116 no 3049 0.105543456696375 4318 4912240 SGTC_217 ketoconazole 989 nM -1.25060030880914 0.104488329646695 no 3050 0.105540168946567 4139 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4 SGTC_1151 3909-8316 15.3 µM -1.25084994964457 0.104443010670591 no 3051 0.105494613598833 4358 800431 SGTC_3045 9092950 49.47 µM -1.25126172011605 0.104368290336634 no 3052 0.105419503335935 4307 44120432 SGTC_514 4466-0038 2.65 nM -1.25357165550904 0.103949844974691 no 3053 0.104998869524775 4131 5722064 SGTC_890 0929-0006 47.2 µM -1.25482615431056 0.103723102654115 no 3054 0.104770937951135 4326 1378169 SGTC_2295 7971645 200 µM -1.25493683984008 0.103703114219684 no 3055 0.104750844563362 4379 2978226 YKL099C UTP11 SGTC_2702 st077768 96.8 µM -1.25614161817803 0.103485726926591 no 3056 0.104532314629778 4301 6484119 SGTC_183 3914-0051 30.55 µM -1.25649636959719 0.103421779514214 no 3057 0.104468030673979 4350 1596232 SGTC_1607 st000305 50.6 µM -1.25663782002105 0.103396289692242 no 3058 0.104442406650472 4329 5457690 SGTC_1343 1487-0095 224 µM -1.2570839920476 0.103315917935428 no 3059 0.104361611544789 4330 4560101 YGL055W OLE1 SGTC_1816 st051957 91.6 µM -1.25942628419395 0.10289473021349 no 3060 0.10393820031449 4321 674121 SGTC_1248 0469-0687 58.6 µM -1.26264088824368 0.102318717486091 no 3061 0.103359133226223 4303 4017482 SGTC_1579 chlormadinone acetate 49.4 µM -1.26400119751781 0.102075676275359 no 3062 0.103114798565872 4387 45114258 A steroidal progestin. SGTC_1653 st012112 65 µM -1.26404612275324 0.102067656828128 no 3063 0.103106736391984 4328 720429 SGTC_863 0466-0191 129 µM -1.2666804955292 0.10159820538331 no 3064 0.102634778445343 4392 765160 YPR165W RHO1 SGTC_432 NS 1619 61.3 µM -1.26919299988337 0.101151937942264 no 3065 0.102186118556916 4338 4552 A K+/calcium channel activator. SGTC_1827 berberine 7.24 µM -1.27288335961668 0.100499054155511 no 3066 0.101529717473424 4255 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_1388 3346-4487 254 µM -1.27547883506023 0.100041718101101 no 3067 0.10106990538552 4413 3345614 SGTC_1369 1866-0067 208 µM -1.27660817303135 0.0998431981376546 no 3068 0.100870307481717 4365 3531355 SGTC_2324 6149169 200 µM -1.27702797566795 0.0997694768051809 no 3069 0.100796185364783 4260 2888231 SGTC_2805 7950783 58.44 µM -1.27765765144789 0.0996589743213668 no 3070 0.100685081642782 4351 1178958 YDL195W SEC31 SGTC_3187 9109394 49.47 µM -1.27826549139587 0.0995523886859639 no 3071 0.100577915518766 4355 17098090 SGTC_255 tunicamycin 200.472 nM -1.27860268844024 0.0994932966225861 no 3072 0.1005185013892 4275 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_2373 9071805 200 µM -1.27866486576189 0.0994824031638818 no 3073 0.100507548539944 4359 10149009 SGTC_3 0833-0587 95.581 µM -1.28098233102759 0.0990770050930947 no 3074 0.100099936150266 4232 5382644 SGTC_2167 5876490 200 µM -1.28367836677691 0.0986069051399793 no 3075 0.0996272584165727 4405 686534 SGTC_1 0258-0098 57.368 µM -1.28452989764923 0.0984587660004683 no 3076 0.0994783047148374 4282 6790032 YDR047W HEM12 SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM -1.28548943528301 0.0982920324815604 no 3077 0.0993106530996271 4367 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_2455 5377712 9.75 µM -1.28571347844081 0.0982531315452599 no 3078 0.099271537763544 4351 2243908 SGTC_609 0986-0026 86.3 µM -1.29381212643377 0.0968545134220362 no 3079 0.0978651615004746 4328 2848610 SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM -1.29443164512117 0.0967481289417222 no 3080 0.0977581829217193 4362 616764 SGTC_2215 7188065 200 µM -1.29758247734855 0.0962083922125312 no 3081 0.0972154233237086 4410 940217 SGTC_2210 7115885 190.385 µM -1.29860432482187 0.0960338262088667 no 3082 0.0970398765061707 4458 2927039 SGTC_1020 4335-0961 93.3 µM -1.29962009161021 0.0958605299314655 no 3083 0.0968656050294584 4326 669075 SGTC_2505 galangin 7.89 µM -1.30110681153022 0.0956073009202942 no 3084 0.0966109482810544 4260 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_3136 9095672 49.47 µM -1.30130479221726 0.0955736165758078 no 3085 0.0965770737754549 4204 17217380 SGTC_1176 0848-0131 83.3 µM -1.30312726457361 0.095263952092242 no 3086 0.0962656584208264 4421 6769040 SGTC_319 1348-1596 45.5 µM -1.30336813169768 0.0952230806085089 no 3087 0.0962245554822901 4442 5380505 SGTC_1707 st032323 6.317 µM -1.3035645200625 0.0951897660498774 no 3088 0.0961910522008161 4214 3132057 YMR211W DML1 SGTC_632 0781-2353 4.65 µM -1.30989690248371 0.0941201607266397 no 3089 0.0951153575838088 4422 6811515 YHR007C ERG11 SGTC_2675 theaflavin digallate 100 µM -1.31019763907543 0.0940695846393097 no 3090 0.0950644921132814 4307 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative. SGTC_2363 9053361 176 µM -1.3108947006885 0.0939524340813043 no 3091 0.0949466707444513 4423 6469797 YMR079W SEC14 SGTC_2933 9026794 32.47 µM -1.31298394241505 0.0936019539714406 no 3092 0.0945941795382115 4313 17586027 SGTC_2699 st077704 54.6 µM -1.31581945500331 0.093127829033769 no 3093 0.0941173238976537 4376 645852 SGTC_2063 5246145 200 µM -1.31972628315606 0.0924774805463404 no 3094 0.0934632107287664 4426 711240 SGTC_2226 7298446 200 µM -1.32056136539887 0.0923389058755366 no 3095 0.0933238310314503 4386 3283010 SGTC_1475 4092-1048 11.7 µM -1.32108106521595 0.0922527438001016 no 3096 0.0932371679040501 4386 2881759 SGTC_1472 k841-0093 193 µM -1.32753667916068 0.0911874108594594 no 3097 0.0921656074948345 4499 X1472 SGTC_2399 5884133 200 µM -1.33159935646252 0.0905216638555382 no 3098 0.0914959382627574 4348 722445 SGTC_333 3486-0131 40.1 µM -1.3329578609038 0.0902998540402134 no 3099 0.0912728164029106 4414 6744690 SGTC_2965 9082772 38.63 µM -1.33479763921559 0.0900001080705016 no 3100 0.090971293187995 4394 16459634 SGTC_552 k242-0005 476 µM -1.334887776524 0.0899854414671152 no 3101 0.0909565394998337 4445 4088318 SGTC_2396 5342950 42.78 µM -1.33856244063067 0.0893890331924463 no 3102 0.0903565801459071 4387 1886677 SGTC_1867 st057372 64 µM -1.34208519328238 0.088820045936805 no 3103 0.0897841871119107 4344 688837 SGTC_365 0121-0052 13.6 µM -1.34212413606571 0.0888137710899945 no 3104 0.0897778746076071 4402 3101739 SGTC_330 1488-0319 80.1 µM -1.34245071035563 0.0887611631971219 no 3105 0.0897249509123455 4437 6846614 SGTC_10 0279-0212 42.575 µM -1.34621038626401 0.0881571869818571 no 3106 0.0891173382145696 4395 39851 YBR002C RER2 SGTC_3125 9127534 49.47 µM -1.35157588160215 0.0873005559430156 no 3107 0.0882555150665196 4300 1639235 SGTC_2745 rifampicin 24.3 µM -1.35190011852467 0.0872489895382089 no 3108 0.0882036348179365 4489 25141428 Inhibits bacterial DNA-dependent RNA polymerase. SGTC_500 h-89 112 µM -1.35218952944807 0.087202981046954 no 3109 0.0881573461848568 4380 449241 Protein kinase A inhibitor; also known to inhibit several other kinases. SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM -1.35427218803498 0.0868724289100008 no 3110 0.0878247778817703 4390 2724278 An inhibitor of dopamine biosynthesis. SGTC_1086 cerivastatin 2.18 µM -1.35431981860325 0.0868648801209752 no 3111 0.0878171829786498 4409 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7 SGTC_185 k048-0037 25.491 µM -1.35749518884584 0.0863627323830307 no 3112 0.0873119605646394 4438 6827589 SGTC_11 0438-0307 1.3 µM -1.35780942436442 0.0863131579814758 no 3113 0.0872620818505012 4392 4011476 SGTC_2262 9014885 67.46 µM -1.3610111138176 0.0858092657670727 no 3114 0.0867550886497662 4431 6457424 SGTC_2700 st077718 96.8 µM -1.3624334254203 0.0855861254282401 no 3115 0.0865305705143538 4384 904970 SGTC_1405 3909-7894 12 µM -1.36347740024868 0.0854226174202364 no 3116 0.0863660511245423 4385 7104060 SGTC_1270 0831-1170 17.3 µM -1.36441025318888 0.0852767114323602 no 3117 0.0862192413519391 4409 6764716 SGTC_3328 9140624 29.0385 µM -1.36464976886577 0.0852392793220596 no 3118 0.0861815771811799 4414 4904392 SGTC_917 harmaline 728.087 nM -1.36644565887635 0.0849590052481219 no 3119 0.0858995630136256 4348 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7 SGTC_2820 7989630 71.43 µM -1.370493877059 0.0843297580058473 no 3120 0.0852663927162302 4442 2984098 SGTC_1365 1672-3266 55.4 µM -1.37375076348733 0.0838260577028287 no 3121 0.0847595356918224 4436 6415873 SGTC_817 1391-0715 46 µM -1.37790152254673 0.0831873930753597 no 3122 0.084116847408219 4396 1353946 SGTC_38 0929-0051 58.268 µM -1.37801525479692 0.0831699450843002 no 3123 0.0840992891602333 4387 1379719 SGTC_487 nimodipine 119 µM -1.37851956889222 0.0830926099642475 no 3124 0.0840214651322893 4434 4497 L-type voltage-gated calcium channels inhibitor SGTC_1736 st036774 51 µM -1.38780011235045 0.0816791030452438 no 3125 0.0825989603075391 4471 1272247 SGTC_967 1306-0166 352 µM -1.39236635841104 0.0809903133480573 no 3126 0.0819057431619395 4434 4437607 SGTC_468 gf-109203x 121 µM -1.39285390274263 0.0809170301538197 no 3127 0.0818319872457808 4482 2396 A protein kinase C inhibitor. SGTC_1862 st057513 3.81 µM -1.39496315276165 0.0806005636646563 no 3128 0.0815134756531953 4416 5393163 SGTC_1532 4',5'-dihydroxyflavone 78.7 µM -1.39923331804876 0.0799627423366418 no 3129 0.0808715141970625 4477 165521 SGTC_2828 7998861 71.43 µM -1.39928954466077 0.0799543694737001 no 3130 0.0808630868218703 4421 2988188 SGTC_478 N-arachidonylglycine 10 µM -1.40051472096283 0.079772089588481 no 3131 0.0806796191331412 4446 5283389 SGTC_1744 st037937 38.9 µM -1.40133939666964 0.0796495726889854 no 3132 0.0805563027333672 4470 1016152 SGTC_1826 st055655 41.6 µM -1.40213404618951 0.0795316513206581 no 3133 0.080437610990517 4452 676168 SGTC_3351 9150312 21.596 µM -1.40235225832096 0.0794992930401011 no 3134 0.0804050411667159 4346 4904905 SGTC_883 0850-0245 24.6 µM -1.40362129584185 0.0793113071919567 no 3135 0.0802158250913384 4491 6823229 YPR165W RHO1 SGTC_793 0488-0545 106 µM -1.40633652811613 0.0789102232105364 no 3136 0.0798121090853238 4451 292548 SGTC_1544 7-methoxy-4-methylcoumarin 105 µM -1.40669933681763 0.0788567470406328 no 3137 0.0797582812441519 4454 390807 SGTC_1344 1488-0097 29.1 µM -1.40984968020586 0.0783935560102735 no 3138 0.0792920367949242 4473 747966 SGTC_3326 9140064 16.379 µM -1.4102119224291 0.0783404285034243 no 3139 0.0792385582173317 4390 1868434 SGTC_2035 5154463 94.595 µM -1.41032080302963 0.0783244650927721 no 3140 0.079222489285076 4456 2769623 SGTC_833 3852-0053 558 µM -1.41034247566106 0.078321287877899 no 3141 0.0792192910662416 4506 3123681 SGTC_467 ro 31-8220 72.8 µM -1.41391047710404 0.0777995490846475 no 3142 0.078694094660093 4393 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7 SGTC_290 2043-6722 48.1 µM -1.41427656805377 0.0777461662085376 no 3143 0.0786403570556098 4465 773758 YLR208W SEC13 SGTC_1557 sumaresinolic acid 42.3 µM -1.41482091449104 0.0776668417770899 no 3144 0.0785605051862069 4409 9982268 A natural terpine and antifungal of unknown mechanisn. SGTC_3245 9134821 49.47 µM -1.41576211674595 0.0775298308486218 no 3145 0.0784225823295177 4464 17014901 SGTC_3117 9124945 49.47 µM -1.41604811524414 0.0774882343911191 no 3146 0.0783807087787425 4350 17592065 SGTC_535 2293-4129 48.2 µM -1.41764200584941 0.0772567246460024 no 3147 0.0781476548597983 4451 396118 YIL048W NEO1 SGTC_956 1185-0240 191 µM -1.42024704131235 0.0768794797086866 no 3148 0.0777678864798811 4426 1416193 SGTC_1138 3761-0006 1.03 µM -1.42291561360637 0.076494487469839 no 3149 0.0773803097191199 4484 12061087 SGTC_766 1391-0721 126 µM -1.42315962287012 0.0764593578138772 no 3150 0.0773449437643166 4464 1020919 YIL115C NUP159 SGTC_916 4466-0038 42 nM -1.4240917904272 0.0763252680146177 no 3151 0.0772099512930559 4506 5722064 YGL116W CDC20 SGTC_1610 st001799 48.1 µM -1.42747021274094 0.0758407902712612 no 3152 0.0767222025833128 4413 621897 SGTC_3199 9111318 49.47 µM -1.42888207478607 0.0756390195306986 no 3153 0.0765190651592419 4367 8548020 SGTC_1464 k208-0027 110 µM -1.43018355636132 0.0754533858774229 no 3154 0.0763321718205436 4453 X1464 SGTC_3195 9113082 49.47 µM -1.43315042731646 0.0750315115668298 no 3155 0.0759074264802695 4451 17018038 SGTC_780 0109-0199 192 µM -1.43382248377224 0.0749361988555502 no 3156 0.0758114635353902 4492 610414 SGTC_1635 st007035 42.4 µM -1.43629508569139 0.0745863231750494 no 3157 0.0754591959182911 4413 3716403 SGTC_3202 9113761 49.47 µM -1.4382384806956 0.074312206992499 no 3158 0.0751832001712772 4386 4798415 SGTC_3164 9100705 49.47 µM -1.44075840421199 0.0739579176597482 no 3159 0.074826474272276 4471 17174235 SGTC_756 0508-1999 28.3 µM -1.44269445006971 0.0736865965892928 no 3160 0.0745532816713648 4469 6753853 SGTC_323 4013-0906 34.3 µM -1.44777489702616 0.0729782317482135 no 3161 0.0738400077507028 4476 2910086 SGTC_3176 9106582 49.47 µM -1.45039123528769 0.0726154757712432 no 3162 0.0734747249232495 4477 17018027 SGTC_2025 5147754 141 µM -1.45257941681966 0.0723131456984756 no 3163 0.0731702821937752 4434 315777 YLR208W SEC13 SGTC_1835 st008666 49.2 µM -1.45365879753874 0.0721643687686021 no 3164 0.0730204633736316 4420 690455 SGTC_761 k216-0224 480 µM -1.45544483482833 0.0719187049623042 no 3165 0.0727730759159501 4473 1340404 SGTC_2932 9016711 44.54 µM -1.45596723570858 0.0718469717188126 no 3166 0.0727008386030233 4453 7117328 SGTC_2235 salicylic acid 500 µM -1.45622910989485 0.0718110332356899 no 3167 0.0726646474495812 4526 338 A COX inhibitor and kinase inhibitor. SGTC_1609 st001574 46.4 µM -1.45998179568757 0.0712975440651862 no 3168 0.0721475385727522 4464 3960012 SGTC_3263 9137018 49.47 µM -1.46110745268504 0.0711440685006653 no 3169 0.0719929776456261 4428 43844957 SGTC_2024 5144227 134 µM -1.46151317987609 0.0710888126363035 no 3170 0.0719373306246496 4444 3475211 SGTC_2970 9090938 41.86 µM -1.46267760477065 0.0709304129747137 no 3171 0.0717778084953448 4509 17217104 SGTC_945 3381-0768 11.3 µM -1.466680711167 0.0703879279432925 no 3172 0.0712314662232 4479 1126236 YIL048W NEO1 SGTC_2462 5162487 171.77 µM -1.46751835494228 0.070274818446054 no 3173 0.0711175499308012 4434 2259986 SGTC_406 estrone 100 µM -1.46823965459063 0.0701775312881456 no 3174 0.0710195681297857 4467 5870 A steroid. SGTC_3231 9132313 49.47 µM -1.46951675746328 0.0700055328569614 no 3175 0.0708463400053446 4432 4905967 SGTC_2581 avocatin a 64 µM -1.47657372889586 0.0690609518604212 no 3176 0.0698949690901865 4420 6710728 A skin care supplement. SGTC_296 1222-0039 74.9 µM -1.4791721482871 0.0687156362667984 no 3177 0.069547155665062 4491 5984176 SGTC_1313 1220-0047 237 µM -1.47919592228324 0.0687124829920622 no 3178 0.0695439795424579 4476 3528706 SGTC_2525 harmine 47.85 µM -1.47980090849378 0.0686322779154886 no 3179 0.0694631930830716 4470 5280953 A monoamine oxidase inhibitor SGTC_1900 st060200 72.8 µM -1.48244610307686 0.0682824432595707 no 3180 0.0691108172536999 4469 688945 SGTC_2619 obliquin 87.91 µM -1.48433122776305 0.0680339710136161 no 3181 0.0688605348431714 4460 6708593 A bioactive alkalod. YER133W GLC7 SGTC_1987 st072290 61.9 µM -1.48494084323345 0.0679537690987352 no 3182 0.068779747703652 4520 54697379 SGTC_1201 1889-3372 45.9 µM -1.48822762362487 0.0675226127107335 no 3183 0.0683454373278774 4393 5392199 SGTC_1450 4112-4260 37.6 µM -1.50111811715984 0.0658520297963599 no 3184 0.066662506825727 4491 1633175 SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM -1.50560804207759 0.0652777263929146 no 3185 0.066083911387034 4478 6708760 SGTC_858 0438-0351 2.77 µM -1.50740225829603 0.0650493189494903 no 3186 0.0658537901444343 4476 2799119 SGTC_2767 sibutramine 71.45 µM -1.50911894023721 0.0648313629000468 no 3187 0.0656341950856478 4490 64765 A serotonin-norepinephrine reuptake inhibitor.  SGTC_2056 5235370 200 µM -1.5095710838204 0.0647740515839512 no 3188 0.0655764522036513 4416 5511916 SGTC_2008 4012253 172 µM -1.51474801120374 0.0641206524726108 no 3189 0.0649181154098835 4488 603940 SGTC_2184 6075246 200 µM -1.51499179017195 0.0640900110158663 no 3190 0.0648872416073845 4486 2267320 SGTC_2290 7904846 200 µM -1.51850097344745 0.0636501894540261 no 3191 0.0644440771463308 4541 2962154 SGTC_1427 4048-4900 550 nM -1.52064821559952 0.0633822263718979 no 3192 0.0641740701632589 4482 24132586 SGTC_799 1310-0557 151 µM -1.52142580624287 0.0632854045433371 no 3193 0.0640765084703252 4525 5354492 SGTC_1126 isoteolin 1.0172 µM -1.52143576360958 0.0632841654472963 no 3194 0.0640752599010693 4448 133323 SGTC_3194 9111903 49.47 µM -1.52284394862039 0.0631091208592465 no 3195 0.0638988758664782 4498 17087251 SGTC_1786 berberine 21.6 µM -1.52365886250377 0.0630079952818933 no 3196 0.0637969753993756 4416 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_1346 1488-2224 62.4 µM -1.5238857253701 0.0629798655297745 no 3197 0.0637686299588397 4518 3722427 SGTC_1058 3448-5425 97.3 µM -1.52496033064543 0.0628467532628953 no 3198 0.0636344962092082 4453 7279705 SGTC_1645 Cervolide 78 µM -1.52700247235263 0.0625943956607451 no 3199 0.063380198294722 4528 23173 A fragrance. SGTC_2156 5649887 115 µM -1.52922938640457 0.0623201059008054 no 3200 0.063103793989251 4537 54680440 YKL052C | YBR257W ASK1 | POP4 SGTC_435 c-PAF 6.7 µM -1.53270469112284 0.0618939254504229 no 3201 0.0626743164052903 4436 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase SGTC_138 0850-0259 40.9225 µM -1.54018922502748 0.0609838157003823 no 3202 0.0617571177915782 4468 6813004 SGTC_2890 9046729 58.44 µM -1.5492696038242 0.0598937371822066 no 3203 0.0606584617453877 4502 903329 SGTC_1132 3456-3614 2.5 µM -1.55107154018232 0.0596792447972777 no 3204 0.060442270291509 4508 3125502 SGTC_791 1348-1292 225 µM -1.55205185265458 0.0595628069587456 no 3205 0.0603249085415996 4485 5437054 SGTC_1836 st055642 81 µM -1.55685863596021 0.0589944501456271 no 3206 0.0597520260241885 4513 8571 SGTC_2968 9090663 33.37 µM -1.55849227422328 0.0588022594960474 no 3207 0.0595582989986404 4462 25236811 SGTC_1161 k007-0610 110 µM -1.56130875235726 0.0584720669431724 no 3208 0.05922545975233 4462 5843850 SGTC_1306 1185-0270 9.02 µM -1.56190531687625 0.0584023153320339 no 3209 0.0591551478831186 4535 1548076 SGTC_1805 st050013 60.3 µM -1.56377777931483 0.0581838073640257 no 3210 0.0589348821971997 4478 4037144 SGTC_1010 4112-3296 15.2 µM -1.56726997613766 0.0577780001902803 no 3211 0.058525800052986 4557 704384 SGTC_485 niflumic acid 177 µM -1.57145150941836 0.0572950206491725 no 3212 0.0580389046927638 4567 4488 A COX2 inhibitor. SGTC_74 000s-0487 160.283 µM -1.57392105243044 0.0570112767588878 no 3213 0.0577528511032371 4405 677548 SGTC_2937 9044753 11.33 µM -1.57908252801159 0.0564218102752358 no 3214 0.0571585643507099 4475 6465530 YGL099W LSG1 SGTC_946 3434-1334 87.4 µM -1.5808779132512 0.0562178979879803 no 3215 0.0569529776564119 4506 4047976 SGTC_3039 9090270 49.47 µM -1.58752548126102 0.0554679497287618 no 3216 0.0561968402670124 4546 17173750 SGTC_2387 9077560 195.08 µM -1.59010740345558 0.055178807526544 no 3217 0.0559052987317683 4542 5303272 SGTC_2208 7283366 200 µM -1.59157748491043 0.0550147099518017 no 3218 0.0557398361870614 4535 898663 SGTC_1096 rimcazole 32.2 µM -1.59176955802711 0.054993298336688 no 3219 0.0557182462941319 4491 18528119 A dopamine reuptake inhibitor. SGTC_959 1222-0044 107 µM -1.59360460519701 0.0547890657576774 no 3220 0.0555123111925568 4527 6083612 SGTC_1351 1496-0003 46.5 µM -1.59467436758278 0.0546702828892796 no 3221 0.0553925364273264 4564 3891978 SGTC_2230 bromochlorosalicylanilide 954.5 nM -1.59519181500273 0.0546129003520082 no 3222 0.0553346742680878 4567 77254 SGTC_2999 9069765 71.4286 µM -1.59703489721421 0.0544088978615866 no 3223 0.0551289642851212 4503 2097066 SGTC_2920 7982904 15.77 µM -1.61045055582005 0.0529420866392399 no 3224 0.0536497656679832 4524 6456808 SGTC_2555 cholic acid 100 µM -1.61244070007723 0.0527271893749293 no 3225 0.05343303712195 4524 6708657 Influences liver metabolism. SGTC_3040 9091894 49.47 µM -1.61341045659953 0.0526227254319212 no 3226 0.0533276814370347 4454 25236966 SGTC_3178 9107506 49.47 µM -1.62239218807456 0.0516629844663932 no 3227 0.0523597003809483 4530 8897194 SGTC_1263 0774-1208 64.8 µM -1.62381369388412 0.0515123732993212 no 3228 0.0522077882840155 4547 906585 SGTC_1053 3366-3204 134 µM -1.64206137722608 0.0496098471378746 no 3229 0.0502886424260244 4560 3632071 YPR165W RHO1 SGTC_2707 st078556 66.6 µM -1.65271813661219 0.0485249604224463 no 3230 0.0491941207457919 4489 17250899 SGTC_2746 daunorubicin 9.88 µM -1.66886852691251 0.0469170562479506 no 3231 0.0475717191041282 4606 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_2738 aclarubicin 5.55 µM -1.68097007080245 0.0457404787816848 no 3232 0.0463843640465207 4626 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31 SGTC_2741 miltefosine 3.04 µM -1.68122563765156 0.0457158892851271 no 3233 0.0463595477516219 4618 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis. SGTC_2095 5432005 200 µM -1.68479552788495 0.0453735200520598 no 3234 0.0460140140246277 4595 783734 SGTC_424 splitomicin 100 mM -1.68546036856691 0.0453099870889831 no 3235 0.0459498924531595 4566 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_124 0136-0217 7.121 µM -1.68682772735243 0.0451795456047792 no 3236 0.0458182411217155 4632 3976905 SGTC_112 phenothiazine 287.218 µM -1.68841782976109 0.0450282352951505 no 3237 0.0456655251134854 4545 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.  SGTC_829 1635-0120 117 µM -1.6972988046243 0.0441906281783379 no 3238 0.0448200915665433 4570 285054 SGTC_3339 9145883 14.936 µM -1.7020252800465 0.0437499993231984 no 3239 0.0443753146942966 4514 2030670 SGTC_49 0717-0965 32.132 µM -1.70385884072201 0.0435800215573302 no 3240 0.0442037310306842 4634 5889349 YGL099W LSG1 SGTC_2331 7980721 200 µM -1.70511790284487 0.0434636108506806 no 3241 0.0440862186537418 4551 2981221 SGTC_2312 7706453 155.7 µM -1.73178280591616 0.0410566369001263 no 3242 0.0416561203191746 4583 976098 SGTC_3179 9107801 49.47 µM -1.7342095534145 0.0408430553061519 no 3243 0.0414404542488507 4580 4818259 SGTC_2211 7117706 200 µM -1.73512495749946 0.0407627237693362 no 3244 0.0413593373034302 4580 822771 SGTC_3017 9080681 49.47 µM -1.73998424832129 0.0403384394612618 no 3245 0.0409308919332558 4623 16451914 SGTC_3139 9095020 49.47 µM -1.74541739193698 0.0398683038244226 no 3246 0.0404561202231751 4507 25236292 SGTC_1597 7-benzyloxygramine 47.5 µM -1.75420736502837 0.0391171378387751 no 3247 0.0396974908460627 4512 260807 SGTC_2389 9091542 195.52 µM -1.75943010530366 0.0386763007101171 no 3248 0.0392522411212768 4582 3626624 YOL127W RPL25 SGTC_2000 st075254 36.4 µM -1.76167324012579 0.0384882105164533 no 3249 0.0390622608081855 4511 17234175 SGTC_2084 5306078 60.6385 µM -1.76420392974217 0.038276904138906 no 3250 0.038848825683169 4565 679340 SGTC_2763 lisinopril 49.32 µM -1.77393145320675 0.0374734691123474 no 3251 0.0380372446551649 4532 5362119 A lysine-analog of enalapril and an ACE inhibitor. SGTC_3105 9121040 49.47 µM -1.78253080680611 0.0367747329437012 no 3252 0.0373313560306993 4610 41448907 SGTC_1332 1480-0653 17.5 µM -1.79069611205872 0.0361211623976419 no 3253 0.0366710369857765 4635 5749438 SGTC_2670 beta-carotene 100 µM -1.79126777974702 0.0360757632979354 no 3254 0.0366251669912347 4623 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.) SGTC_3106 9121286 49.47 µM -1.80460208920419 0.035030006284182 no 3255 0.0355684854623758 4580 15943471 SGTC_1498 4478-3555 97.6 µM -1.80769203401919 0.0347912585596643 no 3256 0.0353272225472078 4642 3437919 SGTC_565 1418-0001 44.5 µM -1.81145812771833 0.0345020757380896 no 3257 0.0350349825381304 4657 2862145 SGTC_41 0478-0632 82.643 µM -1.8134192779558 0.0343522707498122 no 3258 0.0348835892143996 4594 3750424 SGTC_574 1315-0397 40 µM -1.82392425219712 0.0335589088786494 no 3259 0.0340817623186763 4618 6794277 SGTC_415 dibenzyl ketone 100 µM -1.83133402319829 0.0330084247235622 no 3260 0.0335253511673294 4622 7593 SGTC_571 k831-0106 44.2 µM -1.84012918171073 0.0323646980912631 no 3261 0.0328746369684784 4546 4783639 SGTC_258 haloperidol 50.781 µM -1.84617266793428 0.0319284014626466 no 3262 0.0324335690989269 4634 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_803 4488-1585 147 µM -1.8585654626481 0.031048916869412 no 3263 0.0315443781891932 4653 747204 SGTC_65 0798-0905 34.986 µM -1.86303686683321 0.0307365547338511 no 3264 0.0312285397531267 4607 3602145 SGTC_874 0599-0792 117 µM -1.86892644119866 0.0303290973410234 no 3265 0.0308165245302539 4630 765305 SGTC_542 3381-0244 89.3 µM -1.87496920754486 0.0299157041485575 no 3266 0.0303984799247202 4651 1112843 SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM -1.88497834469691 0.0292412535447998 no 3267 0.0297163807831493 4618 4000243 SGTC_621 3584-0052 32.1 µM -1.89795524891272 0.0283856730753596 no 3268 0.0288509886918491 4684 2273927 SGTC_1162 k048-0130 20.1 µM -1.90018562012416 0.0282407410904056 no 3269 0.0287043823478766 4660 6797406 SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM -1.90530049327309 0.0279106958785724 no 3270 0.028370510699901 4562 4330530 SGTC_2083 5306046 65.942 µM -1.91532771589097 0.027272993965235 no 3271 0.0277253615619646 4661 539837 SGTC_785 1270-0111 65.3 µM -1.94942682653931 0.0251946525240798 no 3272 0.0256222367198525 4597 6741994 SGTC_457 grayanotoxin iii 135 µM -1.97056440701409 0.023974213742772 no 3273 0.0243868605954843 4481 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity. SGTC_2148 5546263 113.568 µM -1.97510462849959 0.0237186565630949 no 3274 0.02412813784969 4707 792097 SGTC_2764 methyldopa 94.69 µM -1.97694381519599 0.0236157874179955 no 3275 0.0240239907048321 4642 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent. SGTC_2705 st078069 42.8 µM -1.97755107061593 0.0235819049947758 no 3276 0.0239896868655786 4669 1530061 SGTC_2021 4019055 173 µM -1.98878505330683 0.0229624315557796 no 3277 0.0233624666244631 4466 44827708 YER133W GLC7 SGTC_321 4534-3890 65.3 µM -2.00468714501619 0.0221090224722123 no 3278 0.0224982518262012 4696 699746 SGTC_2380 9035439 200 µM -2.00504458281129 0.0220901519039563 no 3279 0.0224791405361228 4712 6462575 SGTC_2711 st079103 59.1 µM -2.00826500480868 0.0219207451839406 no 3280 0.0223075692695208 4648 54693780 SGTC_64 000l-0018 272.079 µM -2.01504275035319 0.0215677911400575 no 3281 0.0219500849688457 4601 6811119 SGTC_732 3970-1727 52.7 µM -2.04273675955223 0.0201751118174985 no 3282 0.0205392519178781 4729 1275699 SGTC_2891 9063876 19.48 µM -2.04378749604585 0.02012380983543 no 3283 0.0204872724822765 4718 6472478 SGTC_304 1310-0298 97 µM -2.04682430265507 0.019976159947954 no 3284 0.0203376692960192 4451 1550234 SGTC_121 0557-0495 61.343 µM -2.05572429690278 0.0195487246218836 no 3285 0.0199045492914254 4690 3104427 SGTC_103 0844-0104 51.839 µM -2.06905697140169 0.0189229504111154 no 3286 0.0192703704300244 4528 5375804 SGTC_2030 5175110 200 µM -2.08275255559882 0.0182979664623406 no 3287 0.0186368921108134 4696 2831986 SGTC_801 0866-0028 10.1 µM -2.1125829498781 0.0169973281092171 no 3288 0.0173182396621376 4727 6849771 SGTC_937 3122-0005 46.7 µM -2.11411642772604 0.01693265866193 no 3289 0.0172526622118745 4684 759535 SGTC_813 k007-0158 173 µM -2.11437836457926 0.0169216333888236 no 3290 0.0172414820169002 4698 6523916 SGTC_1499 4480-0877 67.3 µM -2.12742780469675 0.0163800813731635 no 3291 0.016692276977764 4726 2861909 SGTC_3332 9141069 11.198 µM -2.12838043567704 0.0163411350440978 no 3292 0.0166527769554229 4671 17332883 SGTC_2983 9022671 12.99 µM -2.14866269219434 0.0155305599175419 no 3293 0.015830574063357 4698 6405161 SGTC_236 1509-0011 5.31 µM -2.15413459661908 0.0153178794162635 no 3294 0.0156148090481472 4715 3107280 SGTC_1205 4161-2785 76 µM -2.15522376057811 0.0152758458870191 no 3295 0.0155721642143519 4701 3498106 SGTC_2913 7966556 36.57 µM -2.15820560271616 0.0151612757511682 no 3296 0.0154559249993276 4625 2976516 SGTC_357 1325-0123 420 µM -2.17366438232274 0.0145790727393989 no 3297 0.0148651747103184 4713 1098503 SGTC_2038 4100038 30.985 µM -2.17373827254456 0.014576336774135 no 3298 0.0148623983155505 4688 3596803 SGTC_788 1182-0090 188 µM -2.19642923104317 0.0137567811286877 no 3299 0.0140306176694541 4699 5715185 SGTC_2385 9074692 200 µM -2.19965120500658 0.0136436942556277 no 3300 0.0139158256221831 4718 17046906 SGTC_3142 9086498 49.47 µM -2.2096176889094 0.0132989484105658 no 3301 0.0135658533059973 4618 25236367 SGTC_1950 st077106 7.18 µM -2.21050094266356 0.0132687623703903 no 3302 0.0135352075851232 4665 13831864 SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM -2.22238625438751 0.0128682918323503 no 3303 0.013128606735517 4678 6708739 YPR165W RHO1 SGTC_3219 9131112 49.47 µM -2.23072718808762 0.0125935287666696 no 3304 0.0128496027781111 4599 17612988 YMR079W SEC14 SGTC_2863 9028737 58.44 µM -2.23912325883852 0.0123220927456696 no 3305 0.012573948647165 4730 6460917 SGTC_2915 7971052 15.16 µM -2.24032825481455 0.0122835554197623 no 3306 0.0125348101140479 4704 5741558 SGTC_2584 androsterone 48.74 µM -2.24633222444064 0.01209309327931 no 3307 0.0123413679884223 4641 2754130 A steroid. SGTC_58 0957-0393 9 µM -2.30438403101775 0.0103797641061714 no 3308 0.0106005478089401 4274 6997992 SGTC_2861 9024595 19.48 µM -2.31970143073784 0.0099645937054265 no 3309 0.0101785171973216 4731 16482810 SGTC_116 0155-0182 31.788 µM -2.33778038137099 0.00949328814794842 no 3310 0.00969932192107005 4646 771486 SGTC_834 0312-0008 75.7 µM -2.34277922239985 0.00936646131695218 no 3311 0.00957035283628189 4766 6385573 YIL048W NEO1 SGTC_1048 3161-0300 24.5 µM -2.38324646468482 0.00839318472504715 no 3312 0.00858035037195283 4745 2165101 SGTC_2117 5521686 200 µM -2.39611502186276 0.00810287155133429 no 3313 0.00828494483059965 4754 803312 SGTC_936 3005-4620 401 µM -2.43029582514601 0.00737418676705579 no 3314 0.00754325176233454 4754 777207 SGTC_939 1165-0479 45.3 µM -2.44374709474066 0.00710365758296305 no 3315 0.0072678060168594 4734 1377347 SGTC_1874 staurosporine 7.6 µM -2.45598263917513 0.00686522344128539 no 3316 0.00702499724003167 4756 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1 SGTC_2612 dictamnine 15.46 µM -2.46647232839062 0.00666646703869552 no 3317 0.00682256355223958 4697 68085 A quinoline derivative and established mutagen. YOR116C RPO31 SGTC_426 0988-0037 14.6 µM -2.46696341851704 0.00665728788777138 no 3318 0.0068132138859464 4737 5383008 SGTC_1894 3',6'-dihydroxyflavone 78.7 µM -2.4702484685703 0.00659617259452629 no 3319 0.00675096172350391 4764 688662 SGTC_1293 1000-1278 195 µM -2.47752470076505 0.0064625683348853 no 3320 0.00661486255553455 4751 678847 SGTC_2870 9038528 12.99 µM -2.50409166255656 0.00599485832091352 no 3321 0.00613831120299466 4751 6463316 SGTC_2743 auranofin 4.32 µM -2.50686687090844 0.00594777567827712 no 3322 0.00609032895603605 4784 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold. SGTC_3183 9108214 49.47 µM -2.50951759797315 0.00590311136768886 no 3323 0.00604480957833846 4782 4974831 SGTC_2744 captopril 92.04 µM -2.5098238360925 0.00589797052237671 no 3324 0.00603957021023203 4784 44093 angiotensin-converting enzyme (ACE) inhibitor  SGTC_2935 9038016 29.96 µM -2.51785012468853 0.00576464076292755 no 3325 0.00590367758263933 4736 6463195 SGTC_2634 4'-methoxyflavone 100 µM -2.56589584866846 0.00502102761449673 no 3326 0.00514548615918111 4732 77793 From seeds of Psoralea corylifolia (Fabaceae) SGTC_797 k781-0471 270 µM -2.5809430769349 0.00480638679684791 no 3327 0.00492654134063467 4755 23738129 SGTC_2020 4017018 200 µM -2.58124376397862 0.00480218232135422 no 3328 0.00492225209931994 4767 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope. SGTC_2096 5468907 200 µM -2.59537782953186 0.00460820989111588 no 3329 0.00472434936381626 4774 759785 SGTC_1551 6-bromo-3'-methylflavone 63.5 µM -2.60122788429114 0.0045299927863687 no 3330 0.00464453630779478 4770 688751 SGTC_2888 9058547 12.99 µM -2.65594758864451 0.00385383391755038 no 3331 0.00395429523937969 4750 16476514 SGTC_728 3030-5151 22.5 µM -2.67161009836023 0.00367771254293146 no 3332 0.00377441520948554 4791 3125388 SGTC_784 4579-0127 173 µM -2.71931258545058 0.00318492560540621 no 3333 0.00327088773777361 4777 1948547 SGTC_2382 9035899 200 µM -2.74570582334709 0.0029385861555246 no 3334 0.00301904395472484 4783 6462679 SGTC_1341 1486-1360 280 µM -2.83834985126865 0.0022039616566396 no 3335 0.00226737244521278 4791 3976547 SGTC_234 nsc-17383 10.7 µM -2.87465505270374 0.00196472609203447 no 3336 0.00202234559894037 4798 408974 SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM -2.90567366422983 0.00177928303113557 no 3337 0.00183231713294963 4782 803109 SGTC_2986 9022445 71.43 µM -2.90672822472043 0.00177326796533543 no 3338 0.0018261518180772 4777 6459286 SGTC_3283 9109332 35.8195 µM -2.96331976143123 0.00147636367803549 no 3339 0.00152170117984245 4741 17027281 SGTC_2691 st077356 60.2 µM -3.00632736956278 0.0012818801202186 no 3340 0.00132212074489899 4776 2839272 SGTC_2101 5377231 179.231 µM -3.15687587836979 0.000771240957130332 yes 3341 0.000797346053847855 4798 2844213 SGTC_1705 st027868 56.3335 µM -3.16190397815077 0.000757986230841241 yes 3342 0.00078370619937265 4792 292948 SGTC_576 1073-0113 22.7 µM -3.23253686399096 0.000592666320583019 yes 3343 0.000613481519818619 4801 5439563 SGTC_3287 9117173 37.0625 µM -3.32814206081817 0.000421634077981116 yes 3344 0.000437136360891398 4801 2789709 SGTC_1616 st002734 56.1 µM -3.41993105015438 0.000301607383419307 yes 3345 0.000313185048069555 4790 4026101 SGTC_575 k072-0246 11.9 µM -3.66197544255631 0.000119997926453303 yes 3346 0.000125138928032912 4808 6796779 SGTC_3012 9080433 71.4286 µM -3.74545135977328 8.62037962604928e-05 yes 3347 9.0034867203448e-05 4804 17688859 SGTC_584 0986-0246 15.4 µM -3.84829900063957 5.68302241817977e-05 yes 3348 5.94704143405426e-05 4810 53315 YDR232W HEM1 SGTC_431 k089-0097 107 µM -3.85262955775208 5.58295554358014e-05 yes 3349 5.84280556009028e-05 4694 5499420 SGTC_2109 5483026 200 µM -4.14812750325578 1.59224901674974e-05 yes 3350 1.67602852258816e-05 4808 759335 SGTC_2859 9028643 45.46 µM -4.31690223578907 7.49021798230346e-06 yes 3351 7.91170994630422e-06 4797 17151580 SGTC_1338 1486-1223 76 µM -5.54268617120377 1.37010132662582e-08 yes 3352 1.48933217903144e-08 4810 3444526 SGTC_1340 1486-1359 257 µM -5.74310416107478 4.25321753851326e-09 yes 3353 4.64782530163255e-09 4810 4309068