SGTCid condition conc unit RNA15|YGL044C.score RNA15|YGL044C.strain.pval RNA15|YGL044C.strain.significant RNA15|YGL044C.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene SGTC_2801 7907800 81.82 µM 6.48752226424997 1.76659383734941e-11 yes 1 4.36297243012782e-11 2 6620925 SGTC_1229 0139-0193 12.2 µM 6.03901416330547 3.50637927497669e-10 yes 2 7.75293180119043e-10 8 3090752 SGTC_1244 0416-0015 52.5 µM 5.71076177600172 2.74497213497034e-09 yes 3 5.62357951736006e-09 1 96201 SGTC_1972 st070201 17.4 µM 5.12737953132229 8.13222379788762e-08 yes 4 1.46901428953352e-07 1 2829099 SGTC_1840 st055363 71 µM 4.98961639848592 1.72195526390014e-07 yes 5 3.02496554852048e-07 2 676033 SGTC_1197 1601-0112 267 µM 4.94812593119684 2.15043350290735e-07 yes 6 3.74657131684844e-07 3 7350313 SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM 4.88023422737071 3.08191040890617e-07 yes 7 5.29799597830315e-07 1 4213774 SGTC_1745 st081495 74 µM 4.87115157367652 3.23278647214053e-07 yes 8 5.54748406566548e-07 19 13842402 YBL026W LSM2 SGTC_2987 9018338 71.43 µM 4.81227796903064 4.3979763475526e-07 yes 9 7.46098053021388e-07 4 5055682 SGTC_2147 5545932 89.7195 µM 4.54440973196188 1.70781408568125e-06 yes 10 2.75447042671239e-06 8 797404 SGTC_1247 0448-0043 5.84 µM 4.43484605153412 2.91379972557462e-06 yes 11 4.6069053516536e-06 7 3089013 YGL099W LSG1 SGTC_2676 harmalol 100 µM 4.19072591239103 9.17799319219021e-06 yes 12 1.39031699006671e-05 4 5459187 A monoamine oxidase inhibitor SGTC_1233 0325-0408 14.2 µM 4.17626445589116 9.80524573216986e-06 yes 13 1.48167643585617e-05 4 12874 SGTC_1530 rhein 70.4 µM 4.1397919279597 1.15735873370761e-05 yes 14 1.7381048816327e-05 1 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death. SGTC_1721 st082152 9.2685 µM 4.12798181241584 1.22085027993461e-05 yes 15 1.82980526120633e-05 8 5296051 SGTC_430 0958-0115 16.4 µM 4.05667905777396 1.68043175511499e-05 yes 16 2.48877026736691e-05 8 6833180 SGTC_1889 st059080 5.18 µM 4.02072147652316 1.97045269023376e-05 yes 17 2.90100858129898e-05 4 176925 Isolated from Daphnopsis sellowiana. SGTC_2157 5649910 96.377 µM 3.80995157031723 4.88314244668431e-05 yes 18 6.94970081542147e-05 7 2858091 SGTC_259 usnic acid 108.925 µM 3.74546483968638 6.38973173256549e-05 yes 19 9.00300326478246e-05 8 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_2443 5493264 126.67 µM 3.73170529904282 6.76348188571279e-05 yes 20 9.50939603121839e-05 9 5340055 SGTC_69 0096-0274 206.684 µM 3.73066402744319 6.79258858320635e-05 yes 21 9.54878794960393e-05 40 6741392 SGTC_1968 st069590 43.6 µM 3.6996821330146 7.71460425204814e-05 yes 22 0.00010793483653148 16 6384066 SGTC_286 k060-0067 22.9 µM 3.6934499339428 7.9137744457994e-05 yes 23 0.000110616041404474 8 5985051 SGTC_3219 9131112 49.47 µM 3.68379636491185 8.23186369083477e-05 yes 24 0.000114892918185288 20 17612988 YMR079W SEC14 SGTC_1185 1319-0113 81.3 µM 3.68274364713625 8.26726944873998e-05 yes 25 0.000115368580801877 5 4672763 SGTC_1167 k781-0610 148 µM 3.67228404622813 8.62692346725917e-05 yes 26 0.000120196135631852 10 4525169 SGTC_3285 9112818 20.8695 µM 3.65089955211217 9.40851198278339e-05 yes 27 0.000130661717656014 18 17017947 YPR165W RHO1 SGTC_1144 3486-0183 12.5 µM 3.64853519610378 9.49890075354582e-05 yes 28 0.000131869887687368 7 6744069 SGTC_3282 9108498 15.4605 µM 3.61205322209879 0.000110012628594346 yes 29 0.000151891098595264 17 16459645 SGTC_354 2783-3500 4.88 µM 3.58281887637351 0.000123632718477347 yes 30 0.000169953149641237 37 6740761 SGTC_2163 5671233 125 µM 3.52846849621434 0.000153252047520518 yes 31 0.000208985847587474 16 701023 SGTC_1017 4239-0030 168 µM 3.51253872050736 0.00016311941539568 yes 32 0.00022192366270795 4 1149593 SGTC_1878 temozolomide 1 mM 3.48216887822807 0.000183599295586432 yes 33 0.000248684957082442 4 5394 DNA alkylating agent. SGTC_3136 9095672 49.47 µM 3.32973379547254 0.000327921856867636 yes 34 0.00043464525101538 12 17217380 SGTC_276 colchicine 750 µM 3.2456409369233 0.000447218020146044 yes 35 0.000585932711036761 9 2833 A microtubule depolymerizer. SGTC_1964 st076914 61 µM 3.24485903778981 0.000448495576258837 yes 36 0.000587543886020367 18 24208661 SGTC_519 k048-0011 62.8 µM 3.21208002062129 0.000505198508265832 yes 37 0.00065888832409235 19 6836379 SGTC_1238 0333-0287 48.8 µM 3.10460081318952 0.000740993492075091 yes 38 0.000952679916739442 8 7226 SGTC_1286 0929-0070 131 µM 3.07900028420874 0.000810439336470401 yes 39 0.00103848241802482 13 1420408 SGTC_2643 anethole 100 µM 3.07408041339536 0.000824452910488785 yes 40 0.00105576254820664 7 637563 An anti-fungal, anti-helmenthic and channel blocker. SGTC_877 0771-0151 33.1 µM 3.06957045448355 0.000837494436477348 yes 41 0.00107183418759464 9 6166523 SGTC_13 0199-0087 65 µM 3.05152596225231 0.000891595242540757 yes 42 0.0011384067878305 14 4589825 SGTC_1102 cgs 12066b 26.1 µM 3.04755060365292 0.000903937956328658 yes 43 0.00115357338263407 7 6438352 A 5-HT1B full agonist. SGTC_2581 avocatin a 64 µM 3.04521385797491 0.000911266181394644 yes 44 0.00116257456107915 17 6710728 A skin care supplement. SGTC_2873 9040596 71.43 µM 3.03002026530715 0.000960261557383594 yes 45 0.00122268665034938 22 6463863 SGTC_382 3229-0966 23.2 µM 3.0254733083159 0.000975387843477569 yes 46 0.0012412215735851 10 5722370 SGTC_2181 6316240 54.2555 µM 3.00986053175925 0.00102900711265438 no 47 0.00130683837911642 9 12779990 SGTC_3260 9137109 49.47 µM 2.99728436502279 0.00107414961076672 no 48 0.00136198245786533 10 17478346 SGTC_1514 1189-1591 158 µM 2.98344571294539 0.00112591701742436 no 49 0.0014251129658429 14 767698 YMR146C TIF34 SGTC_2741 miltefosine 3.04 µM 2.95259245508388 0.00124966030080502 no 50 0.0015755884469972 9 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis. SGTC_338 4055-0136 114 µM 2.91178274521592 0.00143244885241514 no 51 0.00179686246882802 8 2900563 SGTC_1901 st060216 58.6 µM 2.89819946091577 0.00149850430999681 no 52 0.00187655909235906 12 688792 SGTC_2823 7987624 58.44 µM 2.85100675640745 0.00175017770570032 no 53 0.0021790521711698 33 2239440 SGTC_964 1287-0107 19.4 µM 2.84532447593082 0.00178294398694526 no 54 0.00221831017214142 44 51516812 YPR165W RHO1 SGTC_1569 carminic acid 40.6 µM 2.83537275329068 0.00184167683630912 no 55 0.00228861225662522 12 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM 2.82537307634925 0.00190245932090827 no 56 0.00236127968993868 21 4174840 SGTC_1905 st060207 84.5 µM 2.82268904896892 0.0019190814524361 no 57 0.00238113678820365 13 1948547 SGTC_1174 0739-0097 51.1 µM 2.82248337912849 0.00192036058885343 no 58 0.0023826646010155 17 728447 SGTC_85 0868-0259 160.055 µM 2.78571424610007 0.00216188976849804 no 59 0.00267049658886155 16 83173 SGTC_3271 9137798 49.47 µM 2.78406072774139 0.00217337202676658 no 60 0.00268414910332283 13 6498326 SGTC_959 1222-0044 107 µM 2.77940884768365 0.00220597249088902 no 61 0.00272289675135548 15 6083612 SGTC_2099 5377090 177.372 µM 2.76829473297758 0.00228566211790565 no 62 0.00281752350249648 15 2243829 SGTC_1409 3909-8004 61.9 µM 2.75110832581857 0.00241403332040056 no 63 0.0029696999507255 19 2119279 SGTC_2836 9010338 19.48 µM 2.71713940726491 0.00268711910418788 no 64 0.00329244326822451 23 2994051 SGTC_1181 1222-0449 220 µM 2.71425245474364 0.00271156785435398 no 65 0.00332127620061489 20 658318 SGTC_3224 9130643 49.47 µM 2.70055217338598 0.00283035144841034 no 66 0.00346122392768943 25 17644395 SGTC_2341 7987486 176.74 µM 2.69124106926078 0.00291373820465624 no 67 0.0035593367211764 18 1258686 SGTC_2680 butyl paraben 22.24 µM 2.68375313947815 0.00298239701229533 no 68 0.00364004194478509 6 7184 An antifungal and steroid mimetic. SGTC_996 3970-0799 1.8 µM 2.66970251724438 0.00311517710734539 no 69 0.00379592377230098 41 6615648 YGL040C HEM2 SGTC_1196 1588-0294 184 µM 2.62590510635617 0.00356389929229849 no 70 0.00432094529744565 18 6144269 SGTC_626 0214-0009 33 µM 2.61672269474461 0.00366503104567593 no 71 0.00443892162175406 24 3437874 SGTC_651 3253-0966 34.4 µM 2.61576178458528 0.00367576159091233 no 72 0.00445143227925733 21 781462 SGTC_971 1315-0384 26.7 µM 2.61553416652479 0.00367830754171879 no 73 0.00445440038325512 18 6769120 SGTC_1103 duloxetine 36.1 µM 2.59958845207484 0.00386064921589611 no 74 0.00466678105817519 29 60835 A selective serotonin reuptake inhibitor. SGTC_560 2332-1943 155 µM 2.59431769244022 0.00392267863416476 no 75 0.00473894317860589 18 21177716 SGTC_1735 st034310 56.75 µM 2.58423973011749 0.00404377278728327 no 76 0.00487969663942156 31 871153 SGTC_1142 3253-1408 9.78 µM 2.57307918994483 0.00418177064561327 no 77 0.00503990706621641 14 256655 SGTC_2130 NSC 7 2.4545 µM 2.55712093783984 0.00438641029424514 no 78 0.00527712584941864 22 21448 SGTC_956 1185-0240 191 µM 2.53844436475536 0.00463723716284454 no 79 0.00556732525576785 19 1416193 SGTC_2330 7979373 200 µM 2.52058412892571 0.00488899221932325 no 80 0.00585801139109189 38 1863007 SGTC_2790 5423970 71.43 µM 2.50523018401267 0.00511508043466051 no 81 0.00611858625337567 41 1376240 YKL165C | YIL048W MCD4 | NEO1 SGTC_1077 5-fluorocytosine 377 nM 2.50190793415302 0.0051652086466429 no 82 0.00617630213460532 41 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_3179 9107801 49.47 µM 2.48802872701756 0.00537938730469878 no 83 0.0064226678369453 22 4818259 SGTC_1189 1431-2119 7.28 µM 2.48451311336062 0.00543487699954421 no 84 0.0064864365042888 39 3107275 SGTC_1841 st054148 70 µM 2.47332253473699 0.00561490893066074 no 85 0.00669316349398096 22 675442 SGTC_554 4483-2211 187 µM 2.44787199573481 0.00604420421565909 no 86 0.00718513491314314 18 747107 SGTC_1203 3992-3522 103 µM 2.43978025768803 0.00618666162136004 no 87 0.00734809915295338 41 5322312 SGTC_1933 st074711 15.9 µM 2.43478968239386 0.00627599764266629 no 88 0.00745022379544963 34 17250958 SGTC_1249 0481-0015 10.2 µM 2.42957148433908 0.00637062803204428 no 89 0.0075583418004737 32 4227577 SGTC_1601 4'-hydroxyflavanone 55.5 µM 2.41139861240916 0.00671011835356301 no 90 0.00794573476762046 36 165506 SGTC_1030 k029-0042 36.7 µM 2.38303367694789 0.00727199527478703 no 91 0.00858531172405915 29 6080581 SGTC_1021 4476-0760 85.3 µM 2.36234573147739 0.00770756839184859 no 92 0.00907984887321703 15 746768 SGTC_586 0957-0265 8.15 µM 2.36016194429775 0.00775486044886001 no 93 0.00913347939913716 74 6752309 YPR165W | YPR107C RHO1 | YTH1 SGTC_1362 1611-0397 101 µM 2.34408748113555 0.00811089539132802 no 94 0.00953684852342153 37 27816 SGTC_3263 9137018 49.47 µM 2.33546608690174 0.00830770766182386 no 95 0.00975954276566307 40 43844957 SGTC_2684 capsaicin 100 µM 2.33397035573215 0.00834227636250345 no 96 0.0097986371071743 30 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_167 3672-0051 66.205 µM 2.33024359951183 0.00842895748511753 no 97 0.0098966399068299 44 3237971 SGTC_1628 st004252 77.7 µM 2.32615745689022 0.0085249052919065 no 98 0.0100050761491702 30 692968 SGTC_291 SEC14.278 35.5 µM 2.32022380782616 0.00866594085959892 no 99 0.0101643866637488 31 1068044 SGTC_520 3584-0023 682 µM 2.3152403749117 0.0087859677161367 no 100 0.0102998904035304 48 1340790 SGTC_627 1391-0720 175 µM 2.30688230664739 0.00899054666251106 no 101 0.0105306910769196 40 997839 SGTC_979 1426-2828 121 µM 2.29987553897979 0.00916525322221133 no 102 0.010727636138353 33 747872 SGTC_1551 6-bromo-3'-methylflavone 63.5 µM 2.28199952304597 0.00962450039239326 no 103 0.0112446842073658 23 688751 SGTC_2135 5326629 150.42 µM 2.26195938791933 0.0101631410303004 no 104 0.0118499562914742 28 5020077 SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM 2.26058852674687 0.0102009299529404 no 105 0.0118923744377212 47 4330530 SGTC_83 0170-0301 39.027 µM 2.2585438187565 0.010257521743285 no 106 0.011955887958175 8 3089716 SGTC_1159 4092-0538 61.2 µM 2.25816793264262 0.0102679549583453 no 107 0.0119675958375873 42 717301 SGTC_2358 9037157 4 µM 2.25709299321991 0.0102978424103948 no 108 0.0120011323107759 58 2388925 SGTC_1512 0259-0544 12.2 µM 2.25542863553966 0.0103442676117517 no 109 0.0120532185117976 38 18476 SGTC_1868 st057644 42.7 µM 2.2473559241356 0.0105720439846418 no 110 0.012308644733252 44 688665 SGTC_3321 9137793 26.8275 µM 2.24031344922707 0.0107743077795976 no 111 0.0125352903620437 61 4904192 SGTC_863 0466-0191 129 µM 2.23615199128582 0.010895403919796 no 112 0.0126709083828607 49 765160 YPR165W RHO1 SGTC_2754 granisetron 64.02 µM 2.23133926768263 0.0110369269884875 no 113 0.0128293322253867 39 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients. SGTC_1412 3909-8563 178 µM 2.22413398519609 0.0112517941637373 no 114 0.0130697154731245 28 23767530 SGTC_2588 indole-3-carbinol 100 µM 2.20168359470632 0.0119447615446434 no 115 0.0138438331761374 40 3712 Induces cell cycle arrest. SGTC_2345 9052315 157.45 µM 2.19220292372054 0.0122483361719411 no 116 0.014182428726177 39 6469265 SGTC_2984 9022109 38.96 µM 2.18496535938367 0.0124845642734006 no 117 0.0144456932912712 37 6459207 SGTC_2947 9072639 7.68 µM 2.17509782135371 0.0128129821408061 no 118 0.0148113933496706 58 16488146 SGTC_1626 st003712 1.76 µM 2.17093479101678 0.0129537647554551 no 119 0.0149680509846778 51 24207035 SGTC_832 4083-0019 164 µM 2.16674017458745 0.0130969663070851 no 120 0.0151273357135342 83 1990758 SGTC_848 0368-0089 85.6 µM 2.16589649231541 0.0131259337809821 no 121 0.0151595487098748 44 762535 SGTC_632 0781-2353 4.65 µM 2.15860766646994 0.0133785063033932 no 122 0.0154403087412059 67 6811515 YHR007C ERG11 SGTC_2428 5615643 7.78 µM 2.15853494128288 0.0133810473784122 no 123 0.0154431324020288 60 2253075 SGTC_2318 6029776 164 µM 2.14659991595625 0.0138037534274071 no 124 0.0159125733084449 46 818325 SGTC_270 tamoxifen 5.46 µM 2.14503305742522 0.0138600935930762 no 125 0.0159751020050083 52 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  YIL048W NEO1 SGTC_1640 st009078 66.4 µM 2.1094169369674 0.0151953000169993 no 126 0.0174543044084292 36 690618 SGTC_1533 dihydroergotamine mesylate 29.4 µM 2.10912632621951 0.0152066339750716 no 127 0.01746683950965 68 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release. SGTC_2229 7354935 190 µM 2.10638233881453 0.0153140092811521 no 128 0.0175855770818801 57 318112 SGTC_2963 9082507 9 µM 2.10611173074577 0.0153246336659075 no 129 0.0175973240447128 52 16459611 SGTC_1527 coumarin 137 µM 2.10423943827703 0.0153983155736204 no 130 0.0176787829550416 43 323 A hepatotoxic, DNA x-linker. SGTC_398 bronopol 33.3 µM 2.10342746831488 0.0154303641514125 no 131 0.0177142097094297 58 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them. SGTC_1435 4092-0789 56.7 µM 2.0950381504505 0.0157648578745677 no 132 0.0180838006233647 52 2248285 SGTC_1885 st057546 99.9 µM 2.09097162417115 0.0159292215257785 no 133 0.0182653038601356 41 702008 SGTC_1887 st057648 70.8 µM 2.08554960919354 0.0161506559981267 no 134 0.0185097199781385 52 688672 SGTC_1973 st070275 50.2 µM 2.07763646353661 0.0164785587742576 no 135 0.0188714275385209 26 17118334 SGTC_808 0711-0032 135 µM 2.07545418524271 0.0165699838420387 no 136 0.0189722303836664 54 4252555 SGTC_2346 9031566 143.75 µM 2.07214674614335 0.0167093741882423 no 137 0.0191258789977219 51 4771086 SGTC_987 1497-1013 404 µM 2.06960659542667 0.0168171075232969 no 138 0.0192445999681692 44 1676435 SGTC_1983 st071813 46.9 µM 2.06016141049633 0.0172229253187935 no 139 0.0196915563388614 42 11838595 SGTC_2479 5617353 43.85 µM 2.05391339917287 0.0174959483705109 no 140 0.0199920371165838 58 2731746 SGTC_2367 9070478 135.38 µM 2.05382804342849 0.0174997036493861 no 141 0.0199961688488282 57 572802 SGTC_1120 ficusin 1.78878 µM 2.0533999831737 0.0175185468062533 no 142 0.0200169004715323 46 6199 A DNA cross-linker. SGTC_2802 7925815 54.55 µM 2.05208229953826 0.01757665983239 no 143 0.0200808324227216 56 1262923 SGTC_988 1497-1057 103 µM 2.05171248444024 0.0175929991113202 no 144 0.0200988063671437 43 3533044 SGTC_1363 1636-0063 10.4 µM 2.04856548666308 0.0177325659901502 no 145 0.0202523111997375 53 6072185 SGTC_2207 7258803 200 µM 2.04607177643772 0.0178438299424668 no 146 0.020374654671938 36 3666799 SGTC_835 0312-0010 67.2 µM 2.04249115963609 0.0180046303651337 no 147 0.0205514177263833 52 1626196 SGTC_3146 9095609 49.47 µM 2.03429997712325 0.01837713649426 no 148 0.0209606797485665 37 17173999 SGTC_1818 st052136 56.3 µM 2.03235688158614 0.0184664587792469 no 149 0.02105876993519 70 674169 SGTC_2753 fluvastatin 17.09 µM 2.03214589837643 0.0184761796954873 no 150 0.0210694440023737 65 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5 SGTC_901 1112-0062 60.1 µM 2.02961449008352 0.0185931529198065 no 151 0.0211978704288486 43 1908457 SGTC_301 4119-0100 24.5 µM 2.02793723795921 0.0186710034215928 no 152 0.0212833269884334 46 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1 SGTC_2323 6148992 148.28 µM 2.02183931821256 0.0189563836441963 no 153 0.0215964771946696 51 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42 SGTC_2764 methyldopa 94.69 µM 2.02077576378081 0.0190065356438469 no 154 0.0216514913949939 38 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent. SGTC_2094 5332512 191.667 µM 2.0184102406187 0.0191184868125555 no 155 0.0217742768696316 44 755774 SGTC_2332 7982454 138.89 µM 2.01364017164602 0.0193459417518707 no 156 0.0220236627954721 55 2981748 SGTC_2018 5133068 143 µM 2.01054922176542 0.0194945543805709 no 157 0.0221865460759274 63 785362 SGTC_1323 1348-1351 11.2 µM 1.99895039118712 0.020060901491657 no 158 0.0228068608543645 51 6989654 SGTC_3327 9140648 26.9345 µM 1.99571062866031 0.0202215639699008 no 159 0.022982714748462 86 8029710 SGTC_1236 0330-0013 258 µM 1.97985544605519 0.0210236558603193 no 160 0.0238598869986395 37 4617066 SGTC_298 1391-0729 10 µM 1.97440141876913 0.0213057197095753 no 161 0.0241680584287977 40 3237558 SGTC_2153 5569715 200 µM 1.97414328006204 0.0213191487087933 no 162 0.02418272664346 55 2054701 SGTC_548 1436-0017 110 µM 1.97281919577492 0.0213881433385978 no 163 0.024258082675499 54 9677137 SGTC_2373 9071805 200 µM 1.97262739503079 0.0213981532191027 no 164 0.024269014737213 48 10149009 SGTC_1546 5-methoxyflavanone 78.7 µM 1.96734896292326 0.0216751874452118 no 165 0.0245714969520501 35 147795 SGTC_2480 5767542 37.17 µM 1.96529413370787 0.0217838499349289 no 166 0.0246901020858154 45 2867358 SGTC_3216 9129716 49.47 µM 1.9636638448352 0.0218703891141511 no 167 0.0247845440428368 45 8056934 SGTC_1661 st013063 9.66 µM 1.95845746251273 0.0221487013407471 no 168 0.0250881788718049 57 721395 SGTC_2003 4023581 200 µM 1.95599609892599 0.0222813129380051 no 169 0.02523280682785 57 16641307 SGTC_1713 st033146 12.748 µM 1.94799848071636 0.0227168361457801 no 170 0.0257075724708928 56 674619 SGTC_2292 7671323 168.05 µM 1.93751683343178 0.0232984752197087 no 171 0.0263410988497404 95 937504 SGTC_180 1486-1293 102.781 µM 1.93214041347541 0.0236016505831516 no 172 0.0266710886897494 64 4140536 SGTC_219 mitoxanthrone 164.414 µM 1.92878498468944 0.023792539066753 no 173 0.0268787803289707 57 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA.  YMR168C CEP3 SGTC_1969 st069479 40.1 µM 1.92071732936514 0.0242568212495618 no 174 0.0273836768352944 46 3895485 SGTC_698 k064-0052 127 µM 1.91898296692626 0.0243576187889879 no 175 0.0274932447587209 48 5088751 SGTC_1447 4239-0816 81.9 µM 1.91535230652415 0.024569764184045 no 176 0.0277237945612912 70 1341554 SGTC_2250 alverine citrate 130 µM 1.9132410891083 0.0246938375098035 no 177 0.0278585977795385 97 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1 SGTC_753 1322-0200 289 µM 1.90821041211255 0.0249916033363733 no 178 0.0281820132104772 34 5403907 SGTC_2924 9010168 62.78 µM 1.90756394617335 0.025030085042449 no 179 0.0282237993745 48 2993929 SGTC_656 4090-1979 187 µM 1.90129935999576 0.0254055719682614 no 180 0.0286314064310775 49 22330961 SGTC_711 k292-0785 179 µM 1.89685182341251 0.0256750028879096 no 181 0.0289237486821488 66 4146315 SGTC_920 mycophenolic acid 780.421 nM 1.89591488900341 0.0257320661700023 no 182 0.0289856499043171 46 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_1672 st016598 6.51 µM 1.89449279362751 0.0258188806225666 no 183 0.0290798149986942 81 4665860 YNL267W PIK1 SGTC_75 0159-0059 199.013 µM 1.89379693390066 0.025861449900906 no 184 0.0291259843984035 75 5377270 SGTC_2389 9091542 195.52 µM 1.89368504745064 0.0258683000416859 no 185 0.0291334136008912 65 3626624 YOL127W RPL25 SGTC_1867 st057372 64 µM 1.89308954472819 0.0259047846749652 no 186 0.0291729811667616 48 688837 SGTC_244 nsc-207895 1.295 µM 1.89233504289748 0.0259510725195908 no 187 0.0292231773663825 18 42640 SGTC_506 n9-isopropylolomoucine 153 µM 1.89166278164228 0.025992373268823 no 188 0.0292679626059387 35 6610355 SGTC_2650 prasterone 100 µM 1.8875997859119 0.0262431576716514 no 189 0.0295398494284026 33 16759247 A steroid and weak partial agonist of the androgen receptor. SGTC_1133 3473-0247 50 µM 1.88099385712666 0.0266552189203061 no 190 0.029986377234547 115 711311 SGTC_1590 st077108 57.8 µM 1.88040811519587 0.0266920154487809 no 191 0.0300262392032823 55 5489485 SGTC_2291 7917025 104.35 µM 1.8771690893633 0.0268962590286182 no 192 0.0302474613004132 60 2964612 SGTC_2066 5222451 176 µM 1.87518883065013 0.027021769878044 no 193 0.0303833751073016 99 2281147 SGTC_2670 beta-carotene 100 µM 1.87345300768205 0.0271321898182778 no 194 0.0305029280419899 25 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.) SGTC_2085 5307070 144.047 µM 1.86627313631679 0.0275929259872129 no 195 0.0310015806221028 76 2840351 SGTC_1817 st052116 64.4 µM 1.86466852305552 0.0276967816359661 no 196 0.031113940742354 42 4361398 SGTC_173 1273-0061 2.693 µM 1.86018823845975 0.0279884856996977 no 197 0.0314294492489867 93 2847414 YPL266W DIM1 SGTC_3341 9147222 25.867 µM 1.85989911404656 0.0280073976809991 no 198 0.0314499003624179 53 1939759 SGTC_916 4466-0038 42 nM 1.85989511769106 0.0280076591620463 no 199 0.031450183120281 94 5722064 YGL116W CDC20 SGTC_2445 5742597 35.57 µM 1.85507407316125 0.0283245834610246 no 200 0.0317928247945156 70 1774255 SGTC_2285 7945142 200 µM 1.84958490896726 0.0286890562887508 no 201 0.0321866997663643 62 2970608 SGTC_133 0724-0033 378.92 µM 1.84210347486913 0.0291920855004827 no 202 0.0327300078146382 69 280309 SGTC_1882 5615643 20 µM 1.84046877112167 0.0293029679025805 no 203 0.0328497225026951 56 2253075 SGTC_231 b-estradiol 524 µM 1.83984443893174 0.0293454087274672 no 204 0.0328955395357348 48 450 A steroid. SGTC_1437 4092-1038 11.6 µM 1.83869306464034 0.0294238106628216 no 205 0.0329801720372618 60 3977136 SGTC_197 4544-0043 41.561 µM 1.83784388892545 0.0294817459890286 no 206 0.0330427061476261 86 896523 SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM 1.83744789041666 0.0295087954937901 no 207 0.0330719012427512 61 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_1825 st052143 62.6 µM 1.83304264883311 0.0298110964164791 no 208 0.033398114444823 58 674173 SGTC_2093 5331342 194.4 µM 1.83142311777661 0.0299228774319769 no 209 0.0335187066887787 64 33839 SGTC_1100 amiodarone 5.07 µM 1.83083724699596 0.0299634001173065 no 210 0.0335624195288661 50 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. SGTC_3058 9093861 49.47 µM 1.8287072973088 0.0301111051469344 no 211 0.0337217343519642 70 17217477 SGTC_3078 9116413 49.47 µM 1.82701883116492 0.0302286232255535 no 212 0.0338484690415194 69 17177322 SGTC_288 1315-0019 35.1 µM 1.82407577113823 0.0304343703685162 no 213 0.0340703089477727 93 6811474 SGTC_3103 9120822 49.47 µM 1.82398273422743 0.0304408933814989 no 214 0.034077341266011 84 17141819 SGTC_1549 4'-methoxyflavonol 74.6 µM 1.81855678262782 0.0308233266037233 no 215 0.034489538152779 49 97141 SGTC_1340 1486-1359 257 µM 1.81853489423204 0.030824877364394 no 216 0.0344912092218883 68 4309068 SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM 1.81390216151208 0.0311545561488473 no 217 0.034846394955223 43 1241132 A phosphatase inhibitor. SGTC_1324 1418-0026 34.4 µM 1.80707477084888 0.0316457254296316 no 218 0.0353753108799978 51 1372513 SGTC_2893 9048488 25.97 µM 1.80267945834557 0.0319653015549514 no 219 0.0357192850256298 80 6467338 SGTC_602 3130-1533 38.1 µM 1.80181560246349 0.0320284234723844 no 220 0.0357872110616781 82 720941 SGTC_701 4424-0219 185 µM 1.79802923207373 0.0323063088133044 no 221 0.03608618775124 56 2911779 SGTC_2612 dictamnine 15.46 µM 1.79788982076294 0.0323165782016235 no 222 0.0360972347730635 107 68085 A quinoline derivative and established mutagen. YOR116C RPO31 SGTC_991 3996-0057 64.7 µM 1.79065397917332 0.0328532983976278 no 223 0.0366744195412095 65 715343 SGTC_555 4296-0685 37 µM 1.78538988828545 0.0332483634337725 no 224 0.0370990488291172 74 2908540 YHR072W ERG7 SGTC_91 0417-1751 58.384 µM 1.78138332479082 0.0335516676899604 no 225 0.0374249252394317 75 6795624 SGTC_2260 7964312 200 µM 1.77709309602431 0.0338789672629426 no 226 0.0377764619547476 71 231951 SGTC_3297 9117502 71.43 µM 1.77149403432489 0.034310062984227 no 227 0.0382392919260452 33 7453720 SGTC_44 0929-0055 61.211 µM 1.7712681839062 0.0343275463368349 no 228 0.0382580577787052 76 1379590 SGTC_3043 9092303 49.47 µM 1.77122900601585 0.034330579889533 no 229 0.0382613138236126 59 25236084 SGTC_823 0417-1665 178 µM 1.76755622279926 0.0346159442532131 no 230 0.0385675610103675 70 3429856 SGTC_3277 9138724 49.47 µM 1.763855693918 0.0349054318807451 no 231 0.0388781389672501 63 15943418 SGTC_2024 5144227 134 µM 1.76299958622552 0.0349726863781828 no 232 0.0389502797255949 61 3475211 SGTC_2021 4019055 173 µM 1.75733336803855 0.0354205018050783 no 233 0.039430501701972 119 44827708 YER133W GLC7 SGTC_1373 2887-0003 58.5 µM 1.75231067868753 0.0358213788350304 no 234 0.0398602004091985 96 776948 SGTC_2154 5570129 200 µM 1.75005744129623 0.0360024210147827 no 235 0.0400542012318706 61 673366 SGTC_222 nsc-310342 10.666 µM 1.74643318747708 0.0362951927029498 no 236 0.0403678536598981 50 432556 SGTC_746 1095-0025 46.6 µM 1.74324160263011 0.0365546239850709 no 237 0.0406457106220278 66 6749286 SGTC_1833 st055984 71 µM 1.73602860281772 0.037146531277662 no 238 0.0412793886104092 54 676288 SGTC_450 aminopyrene 156 nM 1.73555769214277 0.0371854455658477 no 239 0.0413210360955584 67 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1 SGTC_2777 climbazole 1.536 µM 1.73393710854208 0.0373196191504623 no 240 0.0414646213585399 80 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2 SGTC_1117 retinoic acid 1.10837 µM 1.73221790218629 0.0374623901060714 no 241 0.0416173863804014 58 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR). SGTC_158 k038-0087 26.446 µM 1.73194675849955 0.0374849478191339 no 242 0.0416415212040722 93 X158 SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM 1.72854897775276 0.0377685666735419 no 243 0.0419449240233789 83 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair. SGTC_1761 st044296 37 µM 1.72791711535695 0.0378215020140454 no 244 0.0420015426719237 81 1826700 SGTC_1300 1094-0077 113 µM 1.72703307802914 0.037895665338925 no 245 0.0420808615147075 71 5532636 SGTC_80 0159-0065 512.242 µM 1.72601563548104 0.0379811670759415 no 246 0.0421722999426349 31 1548079 SGTC_2098 5376439 882.5 nM 1.72600564333987 0.0379820075546605 no 247 0.0421731987415049 60 2844116 SGTC_1061 3448-9325 110 µM 1.72199431263646 0.0383206442965683 no 248 0.0425352743808526 83 723482 SGTC_2661 dactinomycin 12.96 µM 1.71685095764518 0.0387584439134593 no 249 0.0430032037630056 59 45006140 An Actinomycin D Classic transcription inhibitor. SGTC_2042 p-Dimethylaminoacetophenone 200 µM 1.71581182776387 0.0388473869588305 no 250 0.043098244329759 62 75037 A free radical scavenger. SGTC_2589 lobaric acid 100 µM 1.70640249052405 0.0396603579379433 no 251 0.0439665836170673 65 73157 A novel microtubule depolymerizer. SGTC_200 k038-0079 37.545 µM 1.69943112120386 0.0402715661820545 no 252 0.044618991160898 86 3436683 SGTC_844 0330-0132 15.3 µM 1.69390781002093 0.0407612303180555 no 253 0.0451414013219448 69 2828079 SGTC_1206 3978-0017 132 µM 1.69020121900376 0.0410925355413282 no 254 0.0454947326288144 85 3873677 SGTC_9 0092-0002 10.449 µM 1.68827701963781 0.0412653848483077 no 255 0.0456790322110731 83 759368 SGTC_2366 9070441 60.58 µM 1.68793555312962 0.0412961200038489 no 256 0.0457118004480143 74 6837235 SGTC_1910 st062352 60.4 µM 1.68477499868702 0.0415814808284135 no 257 0.0460159951378842 62 2245730 SGTC_397 arbidol 50 µM 1.68258230920576 0.0417803918694867 no 258 0.0462279893710926 77 131410 A RNA synthesis inhibitor. SGTC_1816 st051957 91.6 µM 1.68041297581506 0.0419779417633273 no 259 0.0464384965739432 66 674121 SGTC_2772 vinpocetine 57.06 µM 1.67865543876223 0.042138545398367 no 260 0.0466096076358607 70 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor. SGTC_1026 k007-1105 30.6 µM 1.67437310601302 0.0425319471402558 no 261 0.047028647464804 95 7066794 SGTC_2649 anisomycin 9.56 µM 1.67294659311927 0.0426636530668279 no 262 0.0471689051280528 76 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_2142 5622915 118.518 µM 1.67220207506353 0.0427325231684001 no 263 0.0472422407276478 53 5322196 SGTC_3351 9150312 21.596 µM 1.66673754123236 0.0432407631951323 no 264 0.0477833022902079 102 4904905 SGTC_2286 7945697 125 µM 1.66595230427479 0.0433141952506352 no 265 0.047861457314147 74 1245733 SGTC_2035 5154463 94.595 µM 1.66051186924106 0.0438257314766121 no 266 0.0484057610690644 100 2769623 SGTC_1957 st077035 62.4 µM 1.65669411341824 0.0441875968640853 no 267 0.0487906668720425 70 705593 SGTC_1999 st074831 12.5 µM 1.65303503240445 0.0445366790781066 no 268 0.0491618670072273 92 17112523 SGTC_1130 3454-2858 15.9 µM 1.65084381651013 0.0447467859372409 no 269 0.0493852352568899 104 715628 YIL048W NEO1 SGTC_635 k038-0028 24.7 µM 1.64789004011425 0.04503127404204 no 270 0.0496876188009313 104 4035102 SGTC_609 0986-0026 86.3 µM 1.64496052593269 0.045314861408481 no 271 0.0499889758743696 77 2848610 SGTC_490 phenamil 164 µM 1.64101362856976 0.0456992047598252 no 272 0.0503972930947953 71 4755 Irreversibly blocks amiloride-sensitive Na+ channels. SGTC_1049 3226-0134 66 µM 1.63874586389552 0.0459212191314297 no 273 0.0506330989780586 80 5702385 SGTC_3127 9126946 49.47 µM 1.63856431704108 0.0459390299871517 no 274 0.050652014445829 82 27243249 SGTC_1191 1487-1166 10.6 µM 1.63496841859385 0.046292954685459 no 275 0.0510278341261324 59 3955771 SGTC_1831 st055328 12 µM 1.63292078311315 0.0464954685688859 no 276 0.0512428292313748 92 1103068 SGTC_2685 mycophenolic acid 18.85 µM 1.63049904827657 0.0467358985125501 no 277 0.0514980330936083 65 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_1172 0370-0043 85 µM 1.62901228387546 0.0468839980217634 no 278 0.0516552092746793 72 376585 SGTC_216 k038-0035 28.382 µM 1.62477213464929 0.0473084358572336 no 279 0.0521055602899391 100 4444231 YPR107C YTH1 SGTC_789 1309-1135 70.6 µM 1.61951365527006 0.0478390796701343 no 280 0.0526683954141507 64 3092424 SGTC_2717 st081029 62.2815 µM 1.61767056251093 0.0480261938263703 no 281 0.0528668066400691 76 5292846 SGTC_2296 7971656 126.45 µM 1.61273516139007 0.0485301300398255 no 282 0.0534010290159161 63 666570 SGTC_454 lyso-paf C-16 6.67 µM 1.61188205942429 0.0486176642978254 no 283 0.0534938034461815 70 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_763 3453-1109 128 µM 1.6115947483826 0.0486471728276879 no 284 0.0535250771161618 65 1560353 SGTC_831 k061-1017 217 µM 1.60593557753264 0.0492313265969482 no 285 0.0541440327392246 105 1240153 SGTC_1642 st009582 77.7 µM 1.60503152568286 0.0493251618559632 no 286 0.0542434334752164 103 6739311 SGTC_1849 st056239 19.2 µM 1.60391490353827 0.049441257707878 no 287 0.0543664056200824 69 5393181 SGTC_493 zm226600 134 µM 1.60368501076494 0.0494651868481498 no 288 0.0543917507682077 93 5240098 A potassium channel opener. YCR052W RSC6 SGTC_334 1502-1024 68.5 µM 1.60259758268656 0.0495785006609841 no 289 0.0545117638991689 63 3296216 SGTC_317 4495-0002 170 µM 1.59933358114475 0.0499198654972367 no 290 0.0548732508529676 76 15991618 SGTC_583 1488-1091 88.9 µM 1.59913152522655 0.0499410589291656 no 291 0.0548956905947086 104 4303273 SGTC_1958 st076513 41.9 µM 1.59671365771256 0.0501952235755657 no 292 0.0551647749123891 81 732122 YGL099W LSG1 SGTC_1364 1653-0028 37.6 µM 1.59610842626563 0.0502590061946687 no 293 0.0552322938641112 68 5718652 SGTC_601 0986-0029 62.9 µM 1.59534509352868 0.0503395424936025 no 294 0.0553175434778137 87 24747981 SGTC_2316 5844804 197.44 µM 1.59345686983037 0.0505392035965533 no 295 0.0555288682753313 109 776813 SGTC_2183 6420625 130.508 µM 1.59253729573999 0.0506366676885519 no 296 0.0556320149793487 101 2897619 SGTC_2896 9052656 71.43 µM 1.588712847625 0.0510436214548433 no 297 0.0560626185133858 122 6469436 SGTC_1712 st032288 53.4 µM 1.58530092646778 0.0514088719494307 no 298 0.0564489893305195 132 2883011 SGTC_2191 5911152 200 µM 1.58337115745683 0.0516163747232968 no 299 0.0566684464691992 79 2875902 SGTC_468 gf-109203x 121 µM 1.58167269275698 0.0517995564388205 no 300 0.0568621548487916 41 2396 A protein kinase C inhibitor. SGTC_2492 derrusnin 100 µM 1.580869267425 0.0518863867730632 no 301 0.0569539662791256 94 1715307 Part of coumarin class of compounds. SGTC_2879 9041815 71.43 µM 1.58073517270192 0.0519008903408835 no 302 0.0569693013140857 48 4942971 SGTC_1079 idarubicin 2.36 µM 1.58028839968741 0.0519492361677377 no 303 0.0570204176123218 90 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_3083 9117465 49.47 µM 1.57834635820052 0.0521598026953361 no 304 0.0572430306532008 92 16420915 SGTC_1556 plumbagin 1.48 µM 1.57764823987346 0.0522356618559201 no 305 0.0573232217399236 102 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_2375 9072683 200 µM 1.57320378758739 0.0527206628489033 no 306 0.0578358192950051 86 16798029 SGTC_2336 9001819 198.65 µM 1.56827992173207 0.0532621445385537 no 307 0.0584079098008589 139 2989602 SGTC_682 0kpi-0099 17 µM 1.56448167205944 0.053682845650418 no 308 0.0588522469269154 137 1714895 YML126C ERG13 SGTC_1313 1220-0047 237 µM 1.56204289633132 0.0539543535556165 no 309 0.0591389418835358 100 3528706 SGTC_3310 9130229 44.1445 µM 1.55976802181158 0.0542085933028943 no 310 0.0594073554700345 89 7761258 SGTC_2965 9082772 38.63 µM 1.55687182181536 0.054533642999287 no 311 0.0597504603892206 51 16459634 SGTC_1980 st071811 45.7 µM 1.55428128327193 0.0548256915644676 no 312 0.0600586680328026 98 4974850 SGTC_3051 9093778 49.47 µM 1.55250206454367 0.0550269897955281 no 313 0.0602710695509908 106 17217378 SGTC_786 4544-0069 423 µM 1.55028107753038 0.0552790880191797 no 314 0.0605370335158741 99 748821 YLR208W SEC13 SGTC_3061 glucosamine 200 µM 1.54871119209497 0.0554578310602786 no 315 0.0607255810978593 75 91431 and experimental redox chemotherapeutic SGTC_2437 5741531 144.16 µM 1.54677874785888 0.0556784803006732 no 316 0.0609583032733148 108 2262990 SGTC_2237 6667747 47.222 µM 1.54492399965448 0.0558909091508569 no 317 0.0611823237940465 76 729940 YDL015C TSC13 SGTC_2619 obliquin 87.91 µM 1.54310520315709 0.0560998407748009 no 318 0.0614026262515598 106 6708593 A bioactive alkalod. YER133W GLC7 SGTC_937 3122-0005 46.7 µM 1.54159923248623 0.0562733026986276 no 319 0.0615855060958279 90 759535 SGTC_1392 3455-1037 33.9 µM 1.54154475993245 0.0562795849149924 no 320 0.0615921290156381 88 981132 SGTC_989 1501-0895 10.3 µM 1.54108960263577 0.0563320989564695 no 321 0.0616474900069723 80 2830112 SGTC_3166 9102297 49.47 µM 1.53088050517801 0.0575201591444655 no 322 0.062899464071336 87 25237072 SGTC_713 1488-1073 324 µM 1.52545798017199 0.0581591593985548 no 323 0.0635724533102813 86 3312542 SGTC_643 k048-0106 28.4 µM 1.52048393398367 0.0587502023364483 no 324 0.0641946967940828 100 6763920 SGTC_606 k015-0008 38.6 µM 1.51857078739139 0.0589787840879721 no 325 0.0644352844658071 98 1970475 SGTC_1261 0712-0010 12.7 µM 1.51807790605134 0.0590377861801736 no 326 0.0644973800901258 94 2840123 SGTC_841 0251-0215 91.2 µM 1.51784346362647 0.0590658671795368 no 327 0.0645269326149968 94 3888614 SGTC_198 3454-2873 16.191 µM 1.51732060534691 0.0591285317360256 no 328 0.0645928791486324 106 710957 SGTC_1984 st072354 53.1 µM 1.51483854899011 0.0594267177229584 no 329 0.0649066477668648 89 5762938 SGTC_304 1310-0298 97 µM 1.51352947969007 0.0595844590730746 no 330 0.0650726094023609 111 1550234 SGTC_2049 5262831 67.185 µM 1.51340443429257 0.059599544053198 no 331 0.0650884796669078 94 763417 SGTC_2821 7996764 71.43 µM 1.5117598409508 0.0597982199058115 no 332 0.065297484562254 88 2987135 SGTC_370 0180-0345 38.7 µM 1.51165452753465 0.0598109599959078 no 333 0.0653108861472304 88 3989527 SGTC_2002 4023503 131 µM 1.50959923792486 0.060060020656398 no 334 0.0655728579694941 114 4736863 YCR052W RSC6 SGTC_874 0599-0792 117 µM 1.50647748513174 0.0604398682762573 no 335 0.0659723213309436 117 765305 SGTC_109 0132-0036 33.701 µM 1.50479702770763 0.0606451193327448 no 336 0.0661881340852477 88 67274 A color developer. SGTC_2359 9039622 200 µM 1.50168050707306 0.0610272138966231 no 337 0.0665898202335207 91 6463596 SGTC_2338 7999974 200 µM 1.50125126753236 0.0610799870383031 no 338 0.0666452921400585 107 315925 SGTC_218 alverine citrate 93.75 µM 1.49567517343243 0.0617687894776806 no 339 0.0673691614730861 103 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_1796 st049173 110.4 µM 1.49198995120937 0.0622273347049494 no 340 0.0678508898438793 95 94134 SGTC_918 glabranin 770.725 nM 1.49170837215627 0.0622624799535437 no 341 0.0678878066813302 93 124049 Also referred to as licorice root. SGTC_2363 9053361 176 µM 1.49142832132477 0.0622974498116245 no 342 0.0679245385425685 107 6469797 YMR079W SEC14 SGTC_3320 9137005 35.139 µM 1.49107293500545 0.0623418488393633 no 343 0.067971173605259 115 4908713 SGTC_2331 7980721 200 µM 1.49042843743786 0.0624224299859665 no 344 0.0680558099458327 113 2981221 SGTC_1202 1988-0068 29.6 µM 1.48054113035524 0.0636688393059482 no 345 0.0693644463495803 83 2850480 SGTC_2412 st077135 33.4 µM 1.47897967936456 0.0638674365312217 no 346 0.0695728729514667 98 13258915 SGTC_467 ro 31-8220 72.8 µM 1.47823783278929 0.0639619588937945 no 347 0.0696720654128346 102 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7 SGTC_1576 erythromycin ethylsuccinate 23.2 µM 1.47778114456551 0.0640202018862907 no 348 0.0697331834107189 100 3256 An antibiotic and ribosome inhibitor. SGTC_890 0929-0006 47.2 µM 1.47704879974644 0.0641136863703541 no 349 0.0698312783188749 93 1378169 SGTC_1657 st012939 43.4 µM 1.47669745592501 0.0641585733824232 no 350 0.0698783772189249 70 24207257 SGTC_2032 5185112 25.99 µM 1.47645064185729 0.0641901204793328 no 351 0.0699114781463135 80 5718189 SGTC_2663 amphotericin b 100 µM 1.47597992683999 0.0642503194056667 no 352 0.0699746405058571 122 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_465 cgp-37157 41 µM 1.47458577574791 0.0644288724178431 no 353 0.0701619706972747 72 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange. SGTC_169 k015-0017 16.025 µM 1.46343785409095 0.0658705170895755 no 354 0.0716738034961727 101 1840002 SGTC_1510 1123-0200 71.5 µM 1.45571611526391 0.0668836571296258 no 355 0.0727355565466603 125 5378812 YNL149C | YNL150W PGA2 | YNL150W SGTC_2845 9003024 42.97 µM 1.4552283164881 0.0669480619599147 no 356 0.0728030320601165 97 2990173 SGTC_310 1273-0058 1.06 µM 1.45295705103068 0.0672485725507782 no 357 0.0731178395677693 74 2734232 SGTC_2706 st078239 82.5 µM 1.45276013387973 0.0672746756610121 no 358 0.0731451821564207 101 15434492 SGTC_2268 7933382 153.85 µM 1.45178315287008 0.0674042989887016 no 359 0.0732809548697659 102 935025 YOR257W CDC31 SGTC_2960 9079389 5.97 µM 1.44408394029542 0.0684325753470614 no 360 0.0743576824876563 89 16457355 SGTC_1737 st035557 69.7 µM 1.44324523790184 0.0685453161955138 no 361 0.0744757000803015 115 5716916 SGTC_1708 st033234 31.827 µM 1.44197226012734 0.0687167073055449 no 362 0.0746550996727147 110 674664 SGTC_1246 0422-0085 105 µM 1.42741850597275 0.0706997536989548 no 363 0.0767296498825873 125 264295 SGTC_3157 9099274 49.47 µM 1.42490375814707 0.0710468169968462 no 364 0.0770925115794622 97 17217662 SGTC_3114 9122766 49.47 µM 1.42420755157326 0.0711431321714558 no 365 0.0771931997679151 92 17176985 SGTC_998 3996-0085 177 µM 1.41901136244266 0.0718651570066949 no 366 0.077947851731569 107 715391 SGTC_3118 9124250 49.47 µM 1.41568238664096 0.072330672344734 no 367 0.0784342587791746 104 1504786 SGTC_1798 st045719 60.953 µM 1.41485660739006 0.0724465040713703 no 368 0.0785552714318592 110 3980186 SGTC_1038 k292-0204 154 µM 1.41411418744652 0.072550764288791 no 369 0.0786641890788788 103 4454212 SGTC_2826 7992541 19.48 µM 1.41295726605503 0.0727134632039542 no 370 0.0788341447560069 112 2985066 SGTC_3237 9133362 49.47 µM 1.40990155014359 0.073144534816053 no 371 0.0792843774517728 108 43845137 SGTC_2423 st077119 87.2 µM 1.40978026196395 0.0731616852714122 no 372 0.0793022882743092 107 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae). SGTC_381 3461-2219 42.7 µM 1.40674318767863 0.0735921391159961 no 373 0.0797517772045199 105 2883159 SGTC_1645 Cervolide 78 µM 1.40496118463693 0.0738456077426255 no 374 0.0800164104071754 107 23173 A fragrance. SGTC_294 k038-0071 157 µM 1.40357215539871 0.0740436428361786 no 375 0.0802231457621723 123 24152826 SGTC_2208 7283366 200 µM 1.40334317287517 0.0740763279910794 no 376 0.0802572649679698 111 898663 SGTC_1675 st018485 24.5 µM 1.40277558246504 0.0741573938371013 no 377 0.0803418852282229 125 3323024 SGTC_449 xestospongin c 11.1929 µM 1.40243521986259 0.0742060384639331 no 378 0.0803926611389031 101 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1 SGTC_269 exalamide 29 µM 1.39722788494127 0.0749533128258211 no 379 0.0811725269250352 121 3316 A derivative of salicylamide. SGTC_1621 st003705 32.4 µM 1.39533329828316 0.075226613465847 no 380 0.0814576776314419 108 24207032 SGTC_1431 4049-0260 9.09 µM 1.38880568856109 0.0761740636421986 no 381 0.0824459224945956 122 3854841 SGTC_39 0986-0283 58.349 µM 1.38689152258197 0.0764536104133945 no 382 0.0827374216239186 99 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2 SGTC_693 4161-2696 114 µM 1.37809091661401 0.0777489112426487 no 383 0.0840876098379852 121 805759 SGTC_500 h-89 112 µM 1.37606997331544 0.0780486984643913 no 384 0.0843999853425055 122 449241 Protein kinase A inhibitor; also known to inhibit several other kinases. SGTC_1070 indatraline 8.81 µM 1.37171883948305 0.0786971222721022 no 385 0.0850754906322587 124 10314472 A monamine transport inhibitor. YGL099W LSG1 SGTC_1597 7-benzyloxygramine 47.5 µM 1.37170588021749 0.0786990595939373 no 386 0.0850775085680176 152 260807 SGTC_1444 4112-3581 28 µM 1.36979475375261 0.0789851558103476 no 387 0.0853754900978575 107 2877249 SGTC_2455 5377712 9.75 µM 1.36948437921366 0.0790316932367276 no 388 0.0854239571852759 107 2243908 SGTC_1369 1866-0067 208 µM 1.36157300225271 0.0802249444249263 no 389 0.0866663401290221 112 3531355 SGTC_749 1000-0129 128 µM 1.35869420955015 0.0806625073168508 no 390 0.0871217538724991 103 708470 SGTC_761 k216-0224 480 µM 1.35548645333759 0.0811521915354522 no 391 0.0876313108702204 133 1340404 SGTC_928 2764-0428 58.7 µM 1.3530679157062 0.0815228773174401 no 392 0.0880169672155209 141 662578 SGTC_1863 st057641 20.1 µM 1.35190183657815 0.0817020561631764 no 393 0.0882033599775362 124 3921635 SGTC_2421 5690543 90.72 µM 1.35136905915442 0.0817840210856545 no 394 0.0882886200302885 132 3397993 SGTC_1496 4469-0713 57.4 µM 1.34676575844554 0.0824947970072021 no 395 0.0890278430229339 115 746691 SGTC_34 0469-0683 81.75 µM 1.34294719935828 0.0830879249729607 no 396 0.0896445357643085 103 3690923 SGTC_1235 benzylparaben 21.5 µM 1.34112308151807 0.0833723904102709 no 397 0.089940247227589 112 7180 SGTC_518 1021-0119 62.6 µM 1.3377747159321 0.0838964617525958 no 398 0.0904849431958492 131 1097762 SGTC_1273 0849-0096 14.1 µM 1.33642789869772 0.0841079559039654 no 399 0.0907047262752203 135 5286025 SGTC_2498 4'-Methoxychalcone 54.63 µM 1.33623042061457 0.0841390000080656 no 400 0.0907369854103637 101 641818 YHR062C RPP1 SGTC_1489 4065-0444 182 µM 1.33523301088373 0.0842959270377102 no 401 0.0909000479066857 110 2877968 SGTC_1779 st039427 55 µM 1.33382164507862 0.0845183588384793 no 402 0.0911311577495379 114 1124498 SGTC_204 PMA1.184 62.41 µM 1.33304474715781 0.0846409859955632 no 403 0.0912585598726329 119 2252213 YGL008C PMA1 SGTC_1847 st056231 15 µM 1.33162701056324 0.0848651083143175 no 404 0.0914913923039845 121 5393180 SGTC_1343 1487-0095 224 µM 1.32737745793869 0.0855395625955111 no 405 0.0921919263313912 124 4560101 YGL055W OLE1 SGTC_790 1575-0012 79.1 µM 1.31941750256522 0.0868136898434419 no 406 0.093514786780043 125 378741 YLR208W SEC13 SGTC_2944 9067346 25.62 µM 1.31818341200465 0.0870124903076654 no 407 0.093721128531168 141 6473075 SGTC_3107 9121808 49.47 µM 1.31668069116203 0.0872550234869453 no 408 0.0939728392708447 99 662681 SGTC_470 aa-861 153 µM 1.31608117449959 0.0873519238213027 no 409 0.0940733994017042 131 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor. SGTC_1679 SEC14.276 6.7 µM 1.31543854482286 0.087455881725923 no 410 0.094181279251194 153 1005053 YMR079W SEC14 SGTC_2109 5483026 200 µM 1.31023482181583 0.0883010890777031 no 411 0.0950582045546055 181 759335 SGTC_2709 st078560 56 µM 1.30914303847279 0.0884791904993573 no 412 0.0952429514376102 142 17250903 SGTC_1813 st051246 8.6015 µM 1.30600982259607 0.0889917945843206 no 413 0.0957746086207341 118 5291959 SGTC_1783 st039459 87.517 µM 1.30419142794882 0.0892903017310556 no 414 0.0960841609242759 138 729761 SGTC_3188 9110789 49.47 µM 1.30413387031854 0.0892997625235334 no 415 0.0960939711773487 121 849217 SGTC_2192 5915882 198.485 µM 1.30074180186924 0.0898586373903606 no 416 0.0966734243300011 119 2876149 SGTC_1152 3909-8331 15.9 µM 1.30020707397661 0.0899469754808851 no 417 0.0967650033859577 110 16001939 SGTC_439 amiodarone 34.4 µM 1.29818840881295 0.0902810446220044 no 418 0.0971113000990541 121 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1 SGTC_3172 9105863 49.47 µM 1.29629852413507 0.0905946362595986 no 419 0.0974363284304183 113 2348785 SGTC_2985 9022375 71.43 µM 1.29604908445269 0.0906360865205492 no 420 0.0974792873944446 122 4939335 SGTC_2862 9027634 71.43 µM 1.29412476329703 0.0909563309578947 no 421 0.0978111646004967 125 5012562 SGTC_2999 9069765 71.4286 µM 1.2936898625736 0.0910288230404046 no 422 0.0978862841762967 108 2097066 SGTC_3161 9100388 49.47 µM 1.29017749457888 0.0916158587117979 no 423 0.0984945191195626 123 25236368 SGTC_123 0083-0120 66.675 µM 1.28799874204272 0.0919814090787277 no 424 0.0988732005392036 143 16001701 SGTC_570 0987-0065 62.6 µM 1.28455370794731 0.0925616181237839 no 425 0.0994741420484607 113 3104428 SGTC_697 0508-1955 564 µM 1.28433002760807 0.0925993835244167 no 426 0.0995132522752673 116 6243113 SGTC_2902 5787006 60.46 µM 1.28290228047923 0.0928407079203889 no 427 0.0997631569022291 129 591003 SGTC_811 0416-0114 265 µM 1.28286392783944 0.0928471968678128 no 428 0.0997698762446578 121 6612453 SGTC_3238 9133470 49.47 µM 1.27793216873562 0.0936844061106058 no 429 0.100636672156571 106 3534688 SGTC_2230 bromochlorosalicylanilide 954.5 nM 1.27723876813697 0.0938025624395069 no 430 0.100758981943261 100 77254 SGTC_1387 3342-1166 1.8 µM 1.27706984540272 0.093831363740902 no 431 0.100788794847337 104 3418228 SGTC_2967 9089538 49.85 µM 1.27476505542732 0.0942249824141617 no 432 0.101196206363139 149 728216 SGTC_101 0490-5701 117.494 µM 1.27289151412469 0.0945458475988016 no 433 0.101528270446349 107 4661669 SGTC_2758 dehydroepiandrosterone 69.35 µM 1.27256692425852 0.0946015190624431 no 434 0.101585880901945 157 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem] SGTC_2562 3',7'-dimethoxyflavone 64.92 µM 1.27075318011193 0.0949130450379675 no 435 0.101908234954689 116 688664 SGTC_1277 0873-0036 22 µM 1.26728932458651 0.0955100905131487 no 436 0.102525928136041 131 5965735 SGTC_2813 7971799 71.43 µM 1.26316982016157 0.0962237394331164 no 437 0.103264078173051 134 2234054 SGTC_834 0312-0008 75.7 µM 1.26098858037867 0.0966031934586483 no 438 0.103656480764719 128 6385573 YIL048W NEO1 SGTC_417 st075190 100 µM 1.25687675724202 0.0973214836560805 no 439 0.104399133045224 143 222757 SGTC_10 0279-0212 42.575 µM 1.25595025964817 0.0974838721243247 no 440 0.104567002308904 119 39851 YBR002C RER2 SGTC_3325 9138760 55.175 µM 1.25571153112675 0.0975257465732405 no 441 0.104610288464944 113 43844959 SGTC_1759 st043059 70 µM 1.25430843825499 0.0977721243170445 no 442 0.104864959016749 140 669426 SGTC_873 0591-4978 488 µM 1.25393150334361 0.0978383903346686 no 443 0.104933451605315 147 3305145 SGTC_3225 9130819 49.47 µM 1.2533032250151 0.09794891625599 no 444 0.105047687606559 139 4547121 SGTC_2763 lisinopril 49.32 µM 1.25213640820783 0.09815442389829 no 445 0.105260081528338 123 5362119 A lysine-analog of enalapril and an ACE inhibitor. SGTC_1986 st071812 45 µM 1.25163103957462 0.0982435307967232 no 446 0.105352169393143 122 11838594 SGTC_1670 st016595 4.04 µM 1.24626162286928 0.0991939309328503 no 447 0.106334181101088 144 597879 SGTC_2497 7-hydroxyflavone 100 µM 1.24561655033944 0.0993085612221624 no 448 0.106452601634612 141 5281894 SGTC_712 r015-0009 80.6 µM 1.24142652309915 0.100055493253252 no 449 0.107224113054954 126 6813872 YLR060W FRS1 SGTC_689 0833-0039 98 µM 1.240815432636 0.100164770682456 no 450 0.107336969412744 137 5374726 SGTC_917 harmaline 728.087 nM 1.24074455946959 0.10017745011728 no 451 0.107350063828467 135 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7 SGTC_2906 7926292 26.41 µM 1.24069808801681 0.100185764643939 no 452 0.107358650446688 119 2966319 SGTC_2287 7945887 168.79 µM 1.23605507633994 0.101019019161161 no 453 0.10821904594852 145 1245853 SGTC_1192 1488-0095 21.4 µM 1.23504533818447 0.101200897905265 no 454 0.108406815544147 124 915875 SGTC_688 0527-0193 473 µM 1.2336978181178 0.101443991053149 no 455 0.108657763633995 138 4007154 SGTC_1342 1486-1464 234 µM 1.23314374778034 0.101544068860484 no 456 0.108761069039313 141 3253938 SGTC_1193 1488-0126 41.5 µM 1.232295479024 0.101697424922113 no 457 0.108919364006732 127 1384710 SGTC_138 0850-0259 40.9225 µM 1.23200640627944 0.101749724053538 no 458 0.108973345532012 164 6813004 SGTC_910 3454-3003 490 µM 1.23097701606814 0.101936120656803 no 459 0.109165730316096 169 820824 SGTC_1438 4092-1045 4 µM 1.22728699728668 0.102606331878945 no 460 0.109857370488638 153 1351342 SGTC_1953 st076800 12.1 µM 1.22592095381638 0.102855254437711 no 461 0.110114211359164 150 297591 SGTC_2278 7948257 134.34 µM 1.2244688954608 0.103120331541989 no 462 0.110387696582807 120 1247028 SGTC_2834 9001755 58.44 µM 1.22423830178426 0.103162472639303 no 463 0.110431172092605 140 2989575 SGTC_35 0133-0054 64.071 µM 1.22419336733541 0.103170685885628 no 464 0.110439645341377 153 99677 SGTC_3056 9094900 49.47 µM 1.22153238453977 0.103657914919014 no 465 0.110942255889431 129 25236784 SGTC_927 2425-1185 123 µM 1.21945105106899 0.104040171490357 no 466 0.1113365218063 152 730375 SGTC_2732 terfenadine 20 µM 1.21865739720044 0.104186202385139 no 467 0.111487127076773 149 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.  SGTC_2026 5148700 152 µM 1.21840800282126 0.104232121171852 no 468 0.111534482719977 142 79838 SGTC_2442 5158906 48.48 µM 1.21655417613928 0.104573909777992 no 469 0.111886943267016 142 1893835 SGTC_396 dithiazanine 1.25 µM 1.21091832669621 0.105617971424588 no 470 0.112963354019617 114 10578 An antihelmenthic. SGTC_3067 9117431 49.47 µM 1.20955128204684 0.105872353423344 no 471 0.11322556091276 176 17150885 SGTC_25 0118-0223 35.662 µM 1.20457599096988 0.106801902123599 no 472 0.114183514934361 140 5333628 SGTC_501 nsc-95397 161 µM 1.20416077159471 0.106879744233527 no 473 0.114263722421515 154 262093 SGTC_1372 2752-0194 270 µM 1.20260739053982 0.107171323073189 no 474 0.114564143188493 120 823334 SGTC_27 0485-0001 32.618 µM 1.19472733429859 0.108659293315274 no 475 0.116096789589531 139 2054479 SGTC_2284 7945075 39.21 µM 1.19337284235207 0.108916547743478 no 476 0.116361693036467 146 1245402 SGTC_2690 usnic acid 100 µM 1.19233016585334 0.109114878078763 no 477 0.1165659053843 132 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_60 0986-0278 202 µM 1.19002325408603 0.109554604070783 no 478 0.11701862618175 137 3110598 SGTC_1790 st045711 43.5 µM 1.19000267095137 0.109558533190614 no 479 0.117022671127248 103 585119 SGTC_466 geldanamycin 89.2 µM 1.18830051260719 0.109883808894478 no 480 0.117357517923184 103 5288382 HSP90 inhibitor. SGTC_3250 9135583 49.47 µM 1.18649366718462 0.110229847577655 no 481 0.11771370045927 138 7699353 SGTC_1627 st003713 25.6 µM 1.18647381747539 0.110233653437552 no 482 0.117717617666624 140 16195070 YER133W GLC7 SGTC_1747 st037496 66.6 µM 1.18403991832416 0.110701028620096 no 483 0.118198630756978 175 723305 SGTC_2090 5301565 104.445 µM 1.18376987053321 0.110752972569422 no 484 0.118252086015533 153 2056344 SGTC_657 3534-0529 86.7 µM 1.18258595128334 0.110980906688391 no 485 0.11848664148834 149 1049549 SGTC_2400 5203494 178.7 µM 1.18097173168163 0.111292225496482 no 486 0.118806976639434 161 6777674 SGTC_2602 kawain 100 µM 1.18024134431931 0.111433293434939 no 487 0.118952119804919 151 5369129 SGTC_640 3381-0960 37.1 µM 1.18012126570976 0.111456497813127 no 488 0.118975993903231 147 1745025 SGTC_3352 9151559 45.5865 µM 1.17511956639131 0.112426116113352 no 489 0.119973441831524 129 17159339 SGTC_574 1315-0397 40 µM 1.17222776230844 0.112989456623516 no 490 0.120552812522898 180 6794277 SGTC_2233 sulbentine 40.3845 µM 1.17024605765673 0.113376665957692 no 491 0.12095098141468 178 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58 SGTC_997 3996-0078 137 µM 1.1671098956977 0.113991379499281 no 492 0.121582996040095 153 735687 SGTC_224 benfluorex 43.875 µM 1.16002753616977 0.115388307107332 no 493 0.123018797564562 140 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis. SGTC_155 k072-0202 43.6 µM 1.15855009816736 0.115681244839234 no 494 0.123319809827485 168 5857737 SGTC_2513 baicalein 25.65 µM 1.15490467290837 0.116406296999262 no 495 0.124064732813458 157 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2 SGTC_2202 7226349 200 µM 1.15340413808588 0.116705678589717 no 496 0.124372271895104 124 844334 SGTC_1385 3091-4834 14.1 µM 1.15184726909094 0.117016876404977 no 497 0.12469191993737 131 4072814 SGTC_677 0929-0063 136 µM 1.14709784864636 0.117969855282752 no 498 0.125670591461973 153 1539583 SGTC_1952 st077036 64.1 µM 1.14389581486494 0.118615439145747 no 499 0.126333423451077 151 2937007 SGTC_2953 9074162 66.49 µM 1.14338980185678 0.118717687862244 no 500 0.126438392381992 140 16451992 SGTC_3212 9128307 49.47 µM 1.14251926511386 0.118893740611295 no 501 0.126619121425229 130 27243542 SGTC_423 5-fluorouracil 457 µM 1.1422931056445 0.11893950806497 no 502 0.126666103018307 167 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_815 1582-0027 36.9 µM 1.14068084550022 0.119266138535651 no 503 0.127001380177881 166 3128206 SGTC_891 0929-0073 133 µM 1.1387032125582 0.119667654362483 no 504 0.12741348118396 166 5603632 SGTC_2050 5263056 171 µM 1.13826670429593 0.119756406259156 no 505 0.127504566332968 161 763468 YGL055W OLE1 SGTC_666 0272-0154 136 µM 1.12932627320025 0.121584414233767 no 506 0.129380110777489 170 6870312 SGTC_2594 a-mangostin 100 µM 1.12858923383684 0.121735983544874 no 507 0.129535577230095 162 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis. SGTC_702 1488-0190 94 µM 1.1270719040535 0.122048434462779 no 508 0.129856040588756 122 949357 SGTC_3314 9135860 59.4275 µM 1.12310823154741 0.12286729584404 no 509 0.130695765276545 146 25252478 SGTC_2432 5630864 12.22 µM 1.12281546458797 0.12292793145891 no 510 0.130757938023005 151 5714970 SGTC_2462 5162487 171.77 µM 1.12239467333303 0.123015119214197 no 511 0.130847334142711 154 2259986 SGTC_539 4859-0462 2.54 µM 1.117984400903 0.123931534358947 no 512 0.131786827845241 167 46499474 YNL221C | YBR257W POP1 | POP4 SGTC_3071 9117417 49.47 µM 1.11561744241115 0.124425332651521 no 513 0.132292961335067 152 45595590 YGL055W OLE1 SGTC_1374 2889-5571 141 µM 1.11464155284767 0.12462932415573 no 514 0.132502028174357 193 2853281 SGTC_2075 5212009 200 µM 1.11045708477226 0.125506658826746 no 515 0.133401055580425 162 780898 SGTC_2481 5478948 45.16 µM 1.10279933866612 0.127123358081439 no 516 0.135057157690254 156 77792 SGTC_3342 9147791 14.508 µM 1.10128447733541 0.127444884021154 no 517 0.135386432433022 159 1838168 SGTC_3253 9135987 49.47 µM 1.09666068825774 0.128429768688119 no 518 0.136394873659566 175 4182430 SGTC_1956 st077085 54 µM 1.09629076193113 0.128508792046089 no 519 0.136475775439755 185 24208685 SGTC_2222 6885208 172.143 µM 1.09514130564989 0.128754553282136 no 520 0.136727367501973 152 609514 SGTC_2055 5235184 200 µM 1.09329405972376 0.129150189196957 no 521 0.137132355100854 159 2836034 SGTC_814 3342-0569 96 µM 1.09224271950173 0.129375737100881 no 522 0.1373632150233 166 4346283 SGTC_2281 7943571 200 µM 1.09185418738339 0.129459159369935 no 523 0.137448598482406 174 1244024 SGTC_1455 4262-0120 131 µM 1.09183450316614 0.129463386787207 no 524 0.137452925232001 155 1529587 SGTC_3125 9127534 49.47 µM 1.08800473658138 0.13028769438297 no 525 0.138296508259392 144 1639235 SGTC_2033 5192550 145 µM 1.08499380129085 0.130938303535042 no 526 0.138962200352847 158 182073 SGTC_3101 9120531 49.47 µM 1.08468250005229 0.131005697984874 no 527 0.139031150629531 167 24824904 SGTC_2263 7948595 193.29 µM 1.08040604660433 0.131933945426921 no 528 0.139980702214504 152 2971371 SGTC_1653 st012112 65 µM 1.08007256386974 0.132006521427465 no 529 0.140054934122374 152 720429 SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM 1.07945493073506 0.132141009918337 no 530 0.14019248738992 161 5355888 SGTC_1971 st069429 63.5 µM 1.07751199235771 0.132564697113704 no 531 0.140625798053113 148 1246522 YGL099W LSG1 SGTC_425 3825-7017 13.1 µM 1.07655409187935 0.132773925937984 no 532 0.140839761517607 185 3397440 SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM 1.0758092532374 0.132936773953518 no 533 0.141006286539739 171 279621 SGTC_171 k064-0041 9.68 µM 1.06879279121282 0.134477569651054 no 534 0.142581524172585 163 53325 SGTC_1951 sophoraflavanone G 9.2 µM 1.06715198137949 0.134839648704707 no 535 0.142951606013695 161 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity. SGTC_1848 st056003 16.4 µM 1.06517441569652 0.135276928093202 no 536 0.143398504478336 170 146492 SGTC_2474 5321570 43.32 µM 1.06015178979981 0.136391897535746 no 537 0.144537774871614 166 2841384 SGTC_3156 9099931 49.47 µM 1.05986937967669 0.136454775714529 no 538 0.144602013877791 180 18111053 SGTC_714 4296-0578 26.1 µM 1.05944057778308 0.136550285699419 no 539 0.144699588960096 180 1589775 SGTC_2396 5342950 42.78 µM 1.0570435107102 0.137085042942282 no 540 0.145245865100442 219 1886677 SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM 1.05534359867909 0.137465139172167 no 541 0.145634103992181 159 803109 SGTC_166 k072-0058 166.424 µM 1.05308348359818 0.137971608793756 no 542 0.146151365935848 179 5846229 SGTC_528 3492-0019 172 µM 1.05253151253802 0.138095493229102 no 543 0.146277880226559 186 2869262 SGTC_1931 st074438 57.1 µM 1.04909909061551 0.138867568616439 no 544 0.147066257311658 211 2787313 SGTC_887 0885-0007 9.62 µM 1.04868168991287 0.138961657143386 no 545 0.147162322078648 180 5719458 SGTC_2756 carbadox 75.1 µM 1.04710534999994 0.139317379771421 no 546 0.147525496053975 194 2553 A substituted quinoxaline antibiotic. YLR208W SEC13 SGTC_1552 6-methylflavone 10.6 µM 1.04609670343854 0.139545319416285 no 547 0.147758193545233 162 689013 SGTC_3003 9075612 71.4286 µM 1.04452706767827 0.139900538777252 no 548 0.148120801370421 189 6501993 SGTC_1950 st077106 7.18 µM 1.04220796877168 0.140426490685164 no 549 0.148657634652426 158 13831864 SGTC_61 0978-8327 98.565 µM 1.04091887044116 0.1407194270357 no 550 0.148956601466802 166 6150059 YHR072W ERG7 SGTC_2193 5925765 200 µM 1.04076056739621 0.140755428589349 no 551 0.148993342676627 158 877370 SGTC_2629 bisabolol 100 µM 1.03680937695316 0.141656040205926 no 552 0.149912352305176 206 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer. SGTC_1574 spiramycin 23.7 µM 1.03668378739249 0.141684730234398 no 553 0.149941625108298 187 6419898 An antibiotic and protein synthesis inhibitor. SGTC_1913 st060213 96.1 µM 1.03537447327164 0.141984068006324 no 554 0.150247031096339 189 688959 SGTC_1457 k015-0032 57.3 µM 1.03530601846775 0.141999730036553 no 555 0.150263010018435 173 4302660 SGTC_1996 st072960 66.8 µM 1.03423850379037 0.142244122040374 no 556 0.15051233897824 175 1719405 SGTC_715 0868-0130 184 µM 1.02992001576091 0.143235680620881 no 557 0.151523776963466 156 2876258 SGTC_1669 st015249 58.4 µM 1.02950449423484 0.143331333215486 no 558 0.151621334490391 168 722793 SGTC_22 0964-0034 14.468 µM 1.02740727315591 0.143814769354453 no 559 0.152114364072567 208 138402 SGTC_1691 st019933 84.6 µM 1.02533275922368 0.144294052302723 no 560 0.1526031017639 194 6176082 SGTC_54 0159-0055 9 µM 1.02485347150621 0.14440493692293 no 561 0.152716165828288 173 3319099 SGTC_388 3',4'-dichloroisocoumarin 16.7 µM 1.02326234758516 0.144773459780699 no 562 0.153091910588991 186 1609 A potent and irreversible inhibitor of serine proteases. SGTC_2698 st077697 67.5 µM 1.02279571365859 0.144881657646025 no 563 0.15320222254719 175 3154499 SGTC_1388 3346-4487 254 µM 1.02199376944024 0.145067730675349 no 564 0.153391924660375 188 3345614 SGTC_3312 9133330 71.43 µM 1.02051654597509 0.145410907859441 no 565 0.153741773085591 187 17617324 SGTC_1332 1480-0653 17.5 µM 1.01613830666702 0.146431232188732 no 566 0.15478176483707 164 5749438 SGTC_1699 st031318 29.054 µM 1.01407311282166 0.146914178436708 no 567 0.155273933291068 188 5340658 SGTC_2108 5365811 200 µM 1.01265505559605 0.147246409521785 no 568 0.155612476302241 174 780283 SGTC_2930 9013230 14.89 µM 1.01225463814993 0.147340312866178 no 569 0.155708158922619 184 2995857 SGTC_2468 5987765 72.9 µM 1.0118554309677 0.147433972330305 no 570 0.155803590956431 161 26772094 SGTC_2449 5812982 45.77 µM 1.01034438131125 0.147788846453023 no 571 0.156165162447324 162 776185 SGTC_2391 6285546 200 µM 1.00862011254621 0.148194493830661 no 572 0.156578428921573 160 846083 SGTC_3135 9127742 49.47 µM 1.00806375960093 0.148325538918916 no 573 0.156711927072032 181 3643468 SGTC_1148 3909-7663 27.7 µM 1.00748991338857 0.148460785609891 no 574 0.156849701232826 167 4084526 SGTC_541 4513-1321 94 µM 1.00517524224128 0.149007154865859 no 575 0.157406237169282 193 747515 SGTC_1156 4092-0367 4.88 µM 1.00254593414442 0.149629420577523 no 576 0.15803999660169 211 1357585 SGTC_2102 5377816 72.7585 µM 1.00199415244344 0.149760227906483 no 577 0.158173208535308 193 1379702 SGTC_3289 9119912 71.43 µM 1.00138301848307 0.149905194499302 no 578 0.158320835360568 184 17014829 SGTC_1927 st060202 13.8 µM 1.00121884380443 0.149944154183754 no 579 0.15836050914644 184 688887 SGTC_1548 st061468 90.8 µM 1.00088963860968 0.150022296991108 no 580 0.158440083187195 174 390799 SGTC_2928 9011484 9.79 µM 0.999539770380641 0.150342996516374 no 581 0.158766641651965 194 2994751 SGTC_1065 prochlorperazine maleate 2.48 µM 0.997441382925315 0.150842434408646 no 582 0.159275156391176 202 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine. SGTC_53 0973-0023 39.979 µM 0.99689473132298 0.150972724272755 no 583 0.159407804665959 182 674768 SGTC_616 4092-0450 108 µM 0.994806327519804 0.151471167415438 no 584 0.15991523409717 196 787165 SGTC_363 0455-0021 3.06 µM 0.99457441870707 0.151526584935525 no 585 0.159971647188279 190 4597466 SGTC_1154 4088-0362 150 µM 0.992147266066579 0.152107392227508 no 586 0.160562846188401 192 6618304 SGTC_869 0564-0080 44.1 µM 0.992135249093544 0.152110271511082 no 587 0.160565776794905 155 6843321 SGTC_1876 myriocin 605 nM 0.988456561395952 0.152993391789882 no 588 0.161464549192525 203 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1 SGTC_2234 tolnaftate 200 µM 0.987954640712757 0.153114147844708 no 589 0.161587431668309 186 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7 SGTC_3316 9136639 10.545 µM 0.986323487363546 0.153507019771188 no 590 0.161987198844401 193 4903665 SGTC_2728 chlorpromazine 9.18 µM 0.985724403302992 0.153651479824591 no 591 0.162134185496275 220 2726 A thorazine and dopamine antagonist. SGTC_63 0099-0242 26.702 µM 0.985559971412643 0.153691145824175 no 592 0.162174544424916 210 3898502 YLR359W ADE13 SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM 0.978618235421843 0.155371889149826 no 593 0.163884322836062 193 4620898 SGTC_1173 0443-0020 122 µM 0.976966463966894 0.155773598214413 no 594 0.164292877663705 191 5331295 SGTC_442 cape 100 µM 0.976321283393235 0.155930691270974 no 595 0.164452638044839 176 5281787 SGTC_508 roscovitine 141 µM 0.975533009269828 0.156122767432837 no 596 0.164647968051458 209 160355 A CDKinase inhibitor. SGTC_3024 9090631 49.47 µM 0.971970347176709 0.156992813401882 no 597 0.165532650351309 174 25236383 SGTC_2407 paclitaxel 400 µM 0.96467552495106 0.15878423153387 no 598 0.167353678915523 195 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_1659 st012954 42.1 µM 0.95951014045506 0.160060786958253 no 599 0.16865090683375 185 24207262 SGTC_1439 4092-1168 46 µM 0.959404980497135 0.160086845338217 no 600 0.168677383522111 192 2886240 SGTC_1802 st050112 57.9 µM 0.958734662035189 0.160253013799888 no 601 0.16884621599187 179 4662563 SGTC_2152 5568786 200 µM 0.957608180429907 0.160532516563065 no 602 0.16913018629234 203 5399883 SGTC_2664 lyso-paf C-16 73.48 µM 0.953783432221984 0.161483888358831 no 603 0.17009663873622 209 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_675 1309-0189 238 µM 0.952459035189793 0.161814175383594 no 604 0.170432115931523 181 4246530 SGTC_3142 9086498 49.47 µM 0.947840178172818 0.162969498955259 no 605 0.171605411504619 217 25236367 SGTC_1522 st012842 45.6 µM 0.947548950250149 0.163042523640219 no 606 0.171679562624615 208 3491067 YOR116C RPO31 SGTC_1819 st053448 58.6 µM 0.944306686248319 0.163856949621976 no 607 0.172506475081188 220 2857616 SGTC_2745 rifampicin 24.3 µM 0.94278329391325 0.164240521427978 no 608 0.172895879253848 134 25141428 Inhibits bacterial DNA-dependent RNA polymerase. SGTC_1728 st035614 33.7865 µM 0.942126785354585 0.164406001748575 no 609 0.173063866228471 200 15945546 SGTC_189 3970-0742 2.116 µM 0.941434546606731 0.164580605289026 no 610 0.17324110839334 197 2891807 SGTC_1523 st012844 44.7 µM 0.938073449781179 0.165430083004915 no 611 0.1741033325325 162 4274103 SGTC_369 0957-0393 4.5 µM 0.937425079988238 0.165594276637314 no 612 0.174269972537089 195 6997992 SGTC_1245 0418-0076 17.2 µM 0.93399078343477 0.166465737258707 no 613 0.175154323618453 194 6790114 SGTC_1731 st035964 63 µM 0.930165864538598 0.16743979778045 no 614 0.176142606454613 204 6739575 SGTC_2220 6782180 200 µM 0.929091058957445 0.167714169289567 no 615 0.176420948849262 178 833803 SGTC_1843 st055809 45.5 µM 0.92819461833314 0.167943229912866 no 616 0.176653312768854 200 16413835 SGTC_41 0478-0632 82.643 µM 0.925574456502767 0.168613893686045 no 617 0.177333586535942 211 3750424 SGTC_1845 st056753 3.01 µM 0.924539409953384 0.168879300736179 no 618 0.177602771293641 200 5375839 SGTC_1513 0337-0559 19 µM 0.923562755883916 0.169129980736954 no 619 0.17785700622704 192 775073 SGTC_2537 larixol 68.93 µM 0.922668160700143 0.169359808057525 no 620 0.178090081554355 203 6708759 SGTC_2011 4012611 177 µM 0.922628674901016 0.169369956832993 no 621 0.178100373509198 176 2049887 SGTC_1914 st062367 72.6 µM 0.922181736874589 0.169484857589308 no 622 0.178216893834662 206 978205 SGTC_263 alizarin 107.927 µM 0.919322123281976 0.170221202822685 no 623 0.178963554742749 225 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. SGTC_2892 9047358 58.44 µM 0.918915644400101 0.170326036526995 no 624 0.179069848194403 181 6466771 SGTC_1128 3448-9350 235 µM 0.917670012866064 0.170647550980987 no 625 0.179395825750818 171 619386 SGTC_2696 st077691 74.316 µM 0.913501793382171 0.171726248210993 no 626 0.180489345409882 216 757133 SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM 0.912816321580841 0.171904058199184 no 627 0.180669576361616 202 5711223 A potent inhibitor of glutathione S-transferases. SGTC_1869 3',7'-dimethoxyflavone 40.3 µM 0.91221140712301 0.172061069386935 no 628 0.180828720089673 208 688664 SGTC_65 0798-0905 34.986 µM 0.91218393983875 0.172068200948648 no 629 0.18083594839636 195 3602145 SGTC_2633 5,7-dihydroxyisoflavone 100 µM 0.910512046005329 0.172502644023044 no 630 0.181276265941373 204 5377381 SGTC_1304 1165-0502 251 µM 0.90940413824967 0.172790919850702 no 631 0.181568419106868 212 767425 SGTC_327 1273-0057 3.96 µM 0.908391528925572 0.173054667586358 no 632 0.181835699853365 209 3108138 SGTC_191 3914-0123 66.505 µM 0.904873946621959 0.17397286073514 no 633 0.182766085432512 212 3144412 SGTC_2876 9059903 25.97 µM 0.904726739165384 0.174011353647813 no 634 0.182805085855716 193 6916095 SGTC_1704 st028805 70.8 µM 0.902484400731388 0.174598366483013 no 635 0.183399802140423 225 2876101 SGTC_2377 9073351 62.6 µM 0.901952230364233 0.174737865656766 no 636 0.183541122052061 214 7337946 YHR072W ERG7 SGTC_1014 4130-3005 69.3 µM 0.901728002930907 0.174796664145759 no 637 0.183600686836393 200 743608 SGTC_2659 sanguinarine 24.21 µM 0.899906089002984 0.175274884680136 no 638 0.184085114733867 207 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis. SGTC_1789 tunicamycin 25 nM 0.898657834865385 0.175603008021202 no 639 0.18441747136912 212 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_2931 9014674 55.67 µM 0.898375895473143 0.17567717410355 no 640 0.184492591405138 208 2996810 SGTC_2431 5490079 200 µM 0.89583322365998 0.176346937645632 no 641 0.185170921354756 225 5722345 SGTC_2782 7736369 71.43 µM 0.895787288509363 0.176359052232302 no 642 0.185183190088965 223 2950836 YOL077C BRX1 SGTC_1673 st016611 27.3 µM 0.894537444171761 0.176688878714326 no 643 0.185517202421292 233 5226799 SGTC_2386 9075165 157.42 µM 0.893916378551274 0.176852919191825 no 644 0.185683316923762 207 16452277 SGTC_2606 farnesol 9.78 µM 0.891627857507034 0.177458210918994 no 645 0.186296216715589 237 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_1258 0671-0043 57.1 µM 0.890090842869859 0.177865469658981 no 646 0.186708554765446 222 4298767 SGTC_2618 avocadyne 43.43 µM 0.889302137300772 0.178074679582299 no 647 0.186920361582861 206 3015189 SGTC_192 3455-0609 60.9 µM 0.888460859891913 0.178298005491868 no 648 0.187146450364868 195 3769639 SGTC_110 0850-0284 111.64 µM 0.888220482294499 0.178361848650592 no 649 0.187211081605943 182 3906265 SGTC_1799 st045822 46.1415 µM 0.885563140005636 0.17906858575165 no 650 0.187926490761412 222 3674992 SGTC_2172 5754775 163.918 µM 0.885103985227576 0.179190879159751 no 651 0.188050275127254 229 2263357 SGTC_944 3370-0224 231 µM 0.883768900268298 0.179546770220963 no 652 0.18841048892893 185 4580514 SGTC_164 4100-3994 89.624 µM 0.883575540822637 0.179598350486297 no 653 0.188462693707766 231 4615967 SGTC_1921 5740136 50 µM 0.877571587418143 0.181204587463511 no 654 0.190088126934877 182 1774243 SGTC_1614 st002383 48.6 µM 0.876729318993618 0.181430636925513 no 655 0.190316838977982 196 1947235 SGTC_921 1561-0023 372 µM 0.876424044420594 0.181512610614259 no 656 0.190399775849767 218 24050882 SGTC_2828 7998861 71.43 µM 0.873212628583753 0.182376358492276 no 657 0.191273596365114 168 2988188 SGTC_33 0986-0033 35.816 µM 0.868910147743876 0.183537578545187 no 658 0.192448139329656 190 2848082 SGTC_1053 3366-3204 134 µM 0.866052334444146 0.184311430504964 no 659 0.193230731387744 233 3632071 YPR165W RHO1 SGTC_2062 5245942 200 µM 0.864400973849619 0.184759517717658 no 660 0.193683829047432 213 1376160 SGTC_2666 tannic acid 100 µM 0.863510064731794 0.18500154176914 no 661 0.193928544057883 239 16134267 A thiamine antagonist. SGTC_2015 5119600 184 µM 0.862191788094478 0.185360025516439 no 662 0.194290993926938 228 2828786 SGTC_2863 9028737 58.44 µM 0.861362526730367 0.185585750382049 no 663 0.194519204075056 219 6460917 SGTC_2959 9079155 11 µM 0.860684089170145 0.185770547825051 no 664 0.194706029260469 216 16189457 SGTC_1906 st060206 94.7 µM 0.860378626775044 0.185853789004774 no 665 0.194790181794617 231 5133468 SGTC_922 1866-0035 480 µM 0.860126623541139 0.185922479505691 no 666 0.194859623393602 232 3156169 SGTC_1458 k015-0034 6.33 µM 0.858276062316236 0.18642738365664 no 667 0.195370022097415 217 3598957 SGTC_1477 0139-0234 16 µM 0.855748151413888 0.187118465842884 no 668 0.196068549934635 221 620880 SGTC_3048 9093155 49.47 µM 0.855608576132765 0.187156669140442 no 669 0.196107162310401 210 25236002 SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM 0.854594369465279 0.18743441357268 no 670 0.196387872888777 228 23847180 SGTC_779 1360-0071 233 µM 0.85418061452477 0.187547795097465 no 671 0.196502461261452 235 7566 SGTC_275 trichlorophene 5.69 µM 0.851427528423171 0.188303303760022 no 672 0.197265952591236 215 62616 SGTC_2254 7938975 95.19 µM 0.851272881398173 0.188345798000251 no 673 0.197308892778039 219 2969277 SGTC_2622 2-methoxyxanthone 59.94 µM 0.851062315204808 0.188403667339158 no 674 0.197367368893466 212 71034 A hepatoprotective. SGTC_951 1171-0579 82.7 µM 0.849191851224761 0.188918203182632 no 675 0.197887273421254 237 1616050 YPR165W | YDR526C RHO1 | YDR526C SGTC_2267 7931562 200 µM 0.848449177044949 0.189122741310174 no 676 0.198093932558604 199 934880 SGTC_1656 st012921 11 µM 0.847404938855313 0.189410563046422 no 677 0.198384726293089 217 6732821 SGTC_1579 chlormadinone acetate 49.4 µM 0.846822960664217 0.189571089711901 no 678 0.198546904117628 219 45114258 A steroidal progestin. SGTC_2746 daunorubicin 9.88 µM 0.845283129509743 0.189996223883904 no 679 0.198976389029209 191 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_221 trifluoperazine 10.304 µM 0.843562870645013 0.190471865053328 no 680 0.199456859797779 253 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1 SGTC_2817 7995342 71.43 µM 0.842039358888169 0.190893716765145 no 681 0.199882961431509 219 18879975 SGTC_3322 9139058 2.11 µM 0.841339632312539 0.191087658990615 no 682 0.200078846971662 209 4908926 YPR165W RHO1 SGTC_229 benomyl 22.8748 µM 0.8403070951288 0.191374066468014 no 683 0.20036811214632 223 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C SGTC_328 k915-0120 63.5 µM 0.835681405636005 0.19266037683579 no 684 0.201667079309542 201 6624543 SGTC_2933 9026794 32.47 µM 0.835389723229338 0.192741664495151 no 685 0.201749157077533 227 17586027 SGTC_464 bw-b 70c 158 µM 0.834788755249333 0.192909211615654 no 686 0.201918329102893 231 5353454 SGTC_1118 chelidonine 707.474 nM 0.83261697760013 0.193515434528068 no 687 0.202530390424676 224 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor. SGTC_1720 st037298 9.481 µM 0.832373221363053 0.193583548304092 no 688 0.202599156196477 224 597396 SGTC_2162 5663267 200 µM 0.831824724455325 0.193736870438484 no 689 0.202753943007063 222 6456493 SGTC_1960 st011366 51.8 µM 0.831372473947315 0.193863344349154 no 690 0.202881622044735 249 3972846 SGTC_3004 9076122 71.4286 µM 0.829607532871791 0.194357399365712 no 691 0.203380358189291 237 44782551 SGTC_1573 oleylamine 1.06 µM 0.829175899823949 0.194478341758669 no 692 0.203502440067902 241 5356789 An amine of the fatty acid oleic acid. SGTC_2912 7964298 10.93 µM 0.825507678578212 0.195508015085112 no 693 0.204541712560698 234 2975850 SGTC_1071 trifluoperazine 6.31 µM 0.824099552783365 0.19590415515869 no 694 0.204941497125419 245 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. SGTC_3181 9108277 49.47 µM 0.824075558929302 0.195910909431408 no 695 0.204948313304303 236 17097298 SGTC_3201 9113999 49.47 µM 0.823533436736019 0.196063554551183 no 696 0.205102355407499 204 16649224 SGTC_2077 5212015 200 µM 0.822911520096119 0.196238756180325 no 697 0.205279155540314 213 780900 SGTC_2760 etidronate 98.04 µM 0.821654466533135 0.196593173473562 no 698 0.205636790429855 233 3305 A chelator and antioxidant. SGTC_2276 7947513 42.08 µM 0.818892194964482 0.197373337397582 no 699 0.206423961698214 226 2105100 SGTC_444 curcumin 90.4 µM 0.818765133557582 0.19740926905499 no 700 0.206460213597149 226 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. SGTC_2851 9015922 71.43 µM 0.817483564674534 0.197771904657916 no 701 0.206826068939249 246 2996893 SGTC_17 0960-0276 49.807 µM 0.816988311960354 0.197912150238456 no 702 0.2069675537462 237 6821114 SGTC_1828 st055811 49 µM 0.81475244380908 0.198546050471427 no 703 0.20760701371832 232 5877589 SGTC_1578 josamycin 24.2 µM 0.814612500293217 0.198585767121223 no 704 0.207647076452677 236 5282165 A P450 substrate. SGTC_52 0329-0193 875 nM 0.814047887924408 0.198746055516421 no 705 0.20780875887458 236 3739292 SGTC_2078 5212016 200 µM 0.813784097912843 0.198820969866649 no 706 0.207884323270586 228 1899708 SGTC_751 0833-0568 350 µM 0.813190420797358 0.198989631891128 no 707 0.208054445350456 240 6954252 SGTC_2010 4012422 159 µM 0.812928504191685 0.199064069075088 no 708 0.208129525392761 234 952393 SGTC_2868 9035608 32.47 µM 0.811583893687197 0.199446473938974 no 709 0.20851521813085 225 6462614 SGTC_1788 fluconazole 20 µM 0.810984406259436 0.199617109546688 no 710 0.208687312929292 238 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11 SGTC_2762 leflunomide 42.06 µM 0.810871385550989 0.19964928913041 no 711 0.208719767150007 253 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1 SGTC_46 0329-0187a 2.197 µM 0.810870641994175 0.199649500848396 no 712 0.208719980674328 235 46494817 SGTC_1028 k015-0029 4.8 µM 0.810489709886714 0.199757983999322 no 713 0.208829388394358 241 4588309 SGTC_3236 9132701 49.47 µM 0.809364669543071 0.200078583795132 no 714 0.209152709057966 238 24282524 SGTC_3290 9121031 71.43 µM 0.809174896605246 0.200132693363071 no 715 0.209207276148786 230 17014854 SGTC_3356 9151811 4.48 µM 0.808136163797183 0.200429020911374 no 716 0.209506100624541 262 1859254 YPR165W RHO1 SGTC_1605 st000082 49.1 µM 0.808119137963532 0.20043388020025 no 717 0.209511000736893 239 1114022 SGTC_2693 st077581 40.7 µM 0.807064761766009 0.200734944211972 no 718 0.209814586351295 245 25238761 SGTC_2482 5981709 142.65 µM 0.806927539592528 0.200774146249608 no 719 0.209854115620477 244 877755 SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM 0.805816985911611 0.201091581563024 no 720 0.210174191252305 270 6708760 SGTC_2854 9024559 71.43 µM 0.805141250023073 0.20128487786772 no 721 0.210369087130434 228 3163529 SGTC_1814 st052110 31.539 µM 0.805045526888431 0.201312268765648 no 722 0.210396704193125 234 674163 SGTC_220 paclitaxel 373.376 µM 0.802947588644623 0.201913148682595 no 723 0.211002514263837 214 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_2768 sulfasalazine 50.2 µM 0.801797749004292 0.202242934423825 no 724 0.211334980485443 248 5384001 An antioxidant and salicylic acid derivative. SGTC_1259 0671-0132 43 µM 0.801042425743607 0.202459744085632 no 725 0.211553542588251 228 X1259 SGTC_1376 2910-0861 41.3 µM 0.800707880185083 0.202555817173866 no 726 0.211650389744691 245 1112859 SGTC_1309 pyrazolanthrone 13.4 µM 0.799437241745851 0.202920960885992 no 727 0.212018461590532 245 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14 SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM 0.797013105033811 0.203618675273043 no 728 0.212721710157185 255 442882 SGTC_2948 9070189 9.45 µM 0.795777603097909 0.20397482680221 no 729 0.213080655904674 215 6473636 YDL196W YDL196W SGTC_721 1187-1332 279 µM 0.795249452362669 0.20412718716817 no 730 0.213234205299015 243 25730 SGTC_1589 2',5'-dimethoxyflavone 47.2 µM 0.794823593258731 0.204250087903626 no 731 0.213358062398475 230 688667 SGTC_581 0958-0271 211 µM 0.790397733582066 0.20552997467584 no 732 0.21464776270168 236 4591145 SGTC_3139 9095020 49.47 µM 0.789927129454902 0.20566634526593 no 733 0.214785163250692 205 25236292 SGTC_183 3914-0051 30.55 µM 0.789910121350409 0.205671274840982 no 734 0.214790130000752 229 1596232 SGTC_1494 4358-1428 177 µM 0.789084406966927 0.2059106816163 no 735 0.215031337467744 221 1564571 SGTC_1366 1683-0113 21.9 µM 0.7864346003085 0.206680079493594 no 736 0.215806459745948 244 708623 SGTC_960 1222-0186 7.7 µM 0.785911763887513 0.206832091121352 no 737 0.215959591083859 236 3126296 SGTC_706 4262-0057 46.9 µM 0.7852570507952 0.207022538416239 no 738 0.216151435966407 240 883298 SGTC_772 k072-0172 35.3 µM 0.783731896145963 0.207466587715016 no 739 0.216598721305435 228 5861980 SGTC_935 2996-0153 430 µM 0.781684748315051 0.20806349964115 no 740 0.217199933560307 249 23738523 SGTC_1482 3346-2049 8.48 µM 0.780499004350298 0.208409704648656 no 741 0.217548606678514 226 3826804 SGTC_78 0336-0123 156.75 µM 0.7783282221383 0.209044393686668 no 742 0.218187770918167 221 6765896 SGTC_1349 flufenamic acid 69 µM 0.777352708559641 0.209329982735861 no 743 0.218475352802864 254 3371 A non-steroidal anti-inflammatory. SGTC_1329 1447-1697 50.6 µM 0.777187995907433 0.209378226270972 no 744 0.218523931704799 228 2840515 SGTC_2000 st075254 36.4 µM 0.77693811190149 0.209451428572533 no 745 0.218597642171359 232 17234175 SGTC_2926 9010726 65.15 µM 0.776747371340966 0.209507315222287 no 746 0.218653916211294 246 2994293 SGTC_1743 st037606 46.3785 µM 0.77507692424092 0.209997127993058 no 747 0.219147103098686 211 590142 YLR208W | YDL195W SEC13 | SEC31 SGTC_3034 9090421 49.47 µM 0.773357982112866 0.210501862402628 no 748 0.219655274819642 224 17173761 SGTC_250 brefeldin a 552.239 µM 0.771376734308551 0.211084500214995 no 749 0.220241830653636 236 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.  SGTC_1707 st032323 6.317 µM 0.770157064617166 0.211443645587961 no 750 0.220603364618043 245 3132057 YMR211W DML1 SGTC_2221 6807166 181.081 µM 0.770141193729659 0.211448321305483 no 751 0.220608071299485 229 674925 SGTC_1636 st007707 68.9 µM 0.768304447807331 0.211989853358363 no 752 0.221153166413114 260 403051 SGTC_2037 5169046 200 µM 0.76820659333918 0.212018726758175 no 753 0.221182228502374 233 5718022 SGTC_3269 9137823 49.47 µM 0.767976453722896 0.212086641900661 no 754 0.221250586961931 213 17682936 SGTC_1088 bifonazole 369 nM 0.766308885103051 0.212579128118126 no 755 0.221746266393161 242 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase. SGTC_813 k007-0158 173 µM 0.760772852462584 0.214218877039325 no 756 0.223396376008873 244 6523916 SGTC_881 0833-0569 170 µM 0.760460617996637 0.21431157823482 no 757 0.223489650527204 248 5418700 SGTC_1534 6-azauridine 81.6 µM 0.759890744309467 0.21448083165461 no 758 0.223659947304327 250 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1 SGTC_2067 5224629 34.075 µM 0.759232118879526 0.214676541270434 no 759 0.223856857872359 253 2835000 SGTC_2438 5259590 200 µM 0.756188291622766 0.215582357323789 no 760 0.224768155814578 251 1201127 SGTC_897 1000-0139 31.4 µM 0.75582242528582 0.215691384924825 no 761 0.224877834766618 259 6151020 SGTC_2776 terbinafine 19.92 µM 0.753164615683944 0.216484367079131 no 762 0.225675499765488 232 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_1151 3909-8316 15.3 µM 0.752400330801353 0.216712710483397 no 763 0.225905173862113 250 800431 SGTC_1978 st071761 42 µM 0.751871282827181 0.216870854317049 no 764 0.226064234649846 251 5147680 SGTC_2393 9031399 185.94 µM 0.75120451474277 0.21707026065354 no 765 0.22626479177868 254 1526623 YDL150W RPC53 SGTC_3194 9111903 49.47 µM 0.751157645245987 0.217084281617367 no 766 0.226278893431823 247 17087251 SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM 0.751017444471367 0.217126225664773 no 767 0.226321078685292 249 6710655 SGTC_744 1594-0068 283 µM 0.750742391488449 0.217208527224237 no 768 0.226403852758271 261 668392 SGTC_2805 7950783 58.44 µM 0.750359855055046 0.217323020015703 no 769 0.226519001174163 238 1178958 YDL195W SEC31 SGTC_1418 3966-3099 2.4 µM 0.748892042899287 0.217762658087268 no 770 0.226961138328324 255 740335 SGTC_2819 7996655 46.38 µM 0.74787157726399 0.218068609340047 no 771 0.227268811499855 229 6456960 SGTC_750 4073-0104 132 µM 0.74705101125801 0.218314807247916 no 772 0.227516384778753 240 22330957 SGTC_948 3448-0295 75.3 µM 0.745454916414163 0.218794148748196 no 773 0.227998377917487 250 678569 SGTC_856 0433-0016 11.3 µM 0.745250601584186 0.218855552566107 no 774 0.228060118915688 251 3911780 SGTC_2372 9071633 200 µM 0.744731184001759 0.219011700517639 no 775 0.228217121756055 243 21321366 SGTC_576 1073-0113 22.7 µM 0.743670323223315 0.219330816779046 no 776 0.22853797376251 282 5439563 SGTC_864 0469-0573 172 µM 0.741338372487953 0.220033226566076 no 777 0.229244150423059 259 689425 SGTC_775 4577-0580 57.3 µM 0.740197057533964 0.220377473295221 no 778 0.229590216379889 253 2006902 SGTC_1746 st038117 42 µM 0.739200570242279 0.220678288969273 no 779 0.229892607314902 248 2898218 SGTC_899 1083-0020 478 µM 0.73858759124883 0.220863449442081 no 780 0.230078730715037 271 767123 SGTC_1800 st050079 29.0735 µM 0.737399595075712 0.22122255652136 no 781 0.230439690822607 255 3645560 SGTC_2625 euphol 100 µM 0.73503568978407 0.221938109629191 no 782 0.231158879303601 257 6708538 A triterpene alcohol. SGTC_1055 3448-0672 86 µM 0.734884988979326 0.221983771467276 no 783 0.231204770557947 240 748378 SGTC_1443 4112-3303 14 µM 0.733642931517246 0.22236031493913 no 784 0.231583194150228 272 704433 SGTC_709 3807-1509 243 µM 0.733319974629336 0.222458282547663 no 785 0.231681647495523 286 1886677 YPL242C IQG1 SGTC_187 1488-2104 32.728 µM 0.732293662213769 0.222769773441548 no 786 0.231994673418429 257 2852859 SGTC_762 1165-0429 115 µM 0.72974866700431 0.223543263482174 no 787 0.232771913599721 256 5967793 SGTC_2312 7706453 155.7 µM 0.729156925728903 0.223723327632018 no 788 0.232952838182278 243 976098 SGTC_1641 st009299 47.1 µM 0.728452085222933 0.223937914924828 no 789 0.233168444684658 253 4046054 SGTC_1262 0737-0114 49.6 µM 0.72721377502654 0.224315199090181 no 790 0.233547504506552 263 765919 SGTC_2324 6149169 200 µM 0.726281578033398 0.224599455628602 no 791 0.23383308516779 249 2888231 SGTC_353 1988-1175 58.3 µM 0.726224404214128 0.224616896394498 no 792 0.23385060679313 274 2788357 SGTC_515 4092-1064 102 µM 0.725092031332124 0.224962482862616 no 793 0.234197786357466 289 717353 SGTC_1472 k841-0093 193 µM 0.723581282241001 0.22542401404335 no 794 0.234661418072305 269 X1472 SGTC_3011 9081274 71.4286 µM 0.721602174607235 0.226029438227534 no 795 0.235269550895855 268 6625322 SGTC_2832 7992762 51.95 µM 0.720444205636267 0.226384095594429 no 796 0.23562577038451 262 2985177 SGTC_1023 4482-3888 16 µM 0.720165165432931 0.226469605702602 no 797 0.235711654415952 264 3303168 SGTC_2029 5175081 200 µM 0.719622489428998 0.226635957549489 no 798 0.235878730677392 255 1380876 SGTC_2785 7756463 72.73 µM 0.716779971164126 0.22750842866513 no 799 0.236754936001242 298 2201551 SGTC_2184 6075246 200 µM 0.714021412936256 0.22835693500441 no 800 0.237606969358628 264 2267320 SGTC_2408 sulbentine 18.36 µM 0.713760314136144 0.22843733854459 no 801 0.237687701781344 249 67686 An antifungal agent of unknown mechanism. YDL205C HEM3 SGTC_1756 st041558 35.5 µM 0.712497027486491 0.228826583367286 no 802 0.238078525745672 284 3955792 SGTC_1753 st043925 64 µM 0.711689891240781 0.229075473580002 no 803 0.238328414388483 265 670181 SGTC_3228 9131799 49.47 µM 0.710921545209448 0.229312543382086 no 804 0.238566427017548 268 17015818 SGTC_553 k007-0256 45.7 µM 0.709705767678015 0.229687947070413 no 805 0.23894330737607 266 6287000 SGTC_1875 nocodazole 6 µM 0.709380401454242 0.229788470910302 no 806 0.239044223242138 265 4122 A microtubule depolymerizer. YJL014W CCT3 SGTC_2994 9053520 71.4286 µM 0.706383631152392 0.23071549849519 no 807 0.239974798756404 259 4647384 SGTC_2054 5233173 129 µM 0.703011351880337 0.231761180488697 no 808 0.241024337534374 210 6889 SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM 0.702803381821003 0.231825754518531 no 809 0.241089144701856 260 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_3081 9117243 49.47 µM 0.700552958739289 0.232525144219021 no 810 0.241791022102761 278 45595589 SGTC_2114 5491910 81.25 µM 0.69878088989304 0.233076694949497 no 811 0.242344486529385 274 2849228 SGTC_2730 imipramine 71.33 µM 0.698698908120695 0.233102229081338 no 812 0.242370108230124 257 3696 A tricyclic antidepressant. SGTC_1486 3970-0793 4.53 µM 0.696120104189479 0.233906218492418 no 813 0.243176808585689 282 2844330 SGTC_2568 diosmetin 100 µM 0.694807686374142 0.234315978008557 no 814 0.24358791528529 289 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.  SGTC_2381 9035592 200 µM 0.694526881939845 0.234403701572555 no 815 0.243675924243835 268 4749657 SGTC_563 tetrahydrosecaminediol 614 µM 0.690108902184046 0.235786272136991 no 816 0.245062852666687 284 334274 A psychoactive constituent of the cannabis plant. SGTC_2561 acetosyringone 100 µM 0.68932171747797 0.236033086220406 no 817 0.245310417070664 298 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent. SGTC_1985 st071382 65.5 µM 0.685761176594757 0.237151235288984 no 818 0.246431860951539 281 6123237 SGTC_1271 0832-2808 169 µM 0.685015968874556 0.237385627389642 no 819 0.246666922104413 288 3663794 SGTC_502 l-744,832 89.3 µM 0.684382474458027 0.237584982000896 no 820 0.246866839874387 290 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.  SGTC_532 1548-0774 215 µM 0.682838912370392 0.238071110597305 no 821 0.247354319108187 303 5932993 SGTC_2946 9065502 71.43 µM 0.681362653348982 0.2385365523584 no 822 0.247821024010811 235 16489101 SGTC_590 k048-0076 22.4 µM 0.681021768426674 0.238644098876778 no 823 0.24792885822557 291 6832814 SGTC_260 nsc-65238 3.989 µM 0.680923783373341 0.238675017301433 no 824 0.247959859070374 276 3246252 SGTC_1588 farnesol 29.9 µM 0.679130548097098 0.239241245756881 no 825 0.248527574112262 275 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_2699 st077704 54.6 µM 0.678967185991465 0.239292865106994 no 826 0.248579326834176 274 645852 SGTC_1042 0350-0096 82 µM 0.678307345173901 0.239501424291356 no 827 0.248788421230764 283 3122515 SGTC_1611 st001856 99.4 µM 0.678211572881758 0.239531703764247 no 828 0.248818777921226 296 647478 SGTC_1288 0973-0013 65.5 µM 0.675837449502605 0.24028297687815 no 829 0.249571927453432 268 4315430 SGTC_2655 perillic acid 100 µM 0.675496927293469 0.240390837698367 no 830 0.249680051455736 278 5702197 An apoptosis inducer. SGTC_1722 st034304 3.6505 µM 0.67439683686632 0.240739472826823 no 831 0.250029526604639 290 4036148 YLR033W RSC58 SGTC_1264 0783-0040 158 µM 0.673641300583128 0.24097907288072 no 832 0.25026969453951 279 2855798 SGTC_567 1080-0542 68.4 µM 0.672901417532407 0.241213834523068 no 833 0.250505005159138 249 5950415 SGTC_1390 3413-2614 145 µM 0.670997284633997 0.241818578712265 no 834 0.251111129671692 303 3421432 SGTC_842 0271-0008 11.1 µM 0.666389857498046 0.243285274866464 no 835 0.252580971842177 264 1221709 SGTC_1932 st074806 40.9 µM 0.665543052753887 0.243555362876683 no 836 0.252851608163587 284 17251235 SGTC_3131 9127911 49.47 µM 0.664639968898402 0.243843579441001 no 837 0.253140399238148 267 45595681 SGTC_76 0433-0009 400.328 µM 0.663473997454011 0.244215967882996 no 838 0.253513513786656 312 2841569 SGTC_2503 beta-caryophyllene alcohol 24.72 µM 0.660996161057699 0.245008357371802 no 839 0.254307387748651 296 61125 An anti-inflammatory. SGTC_1423 4048-0112 5.59 µM 0.659950828242951 0.245343059649086 no 840 0.254642692364353 270 X1423 SGTC_2553 4-methylesculetin 85.09 µM 0.657788264939009 0.246036264317621 no 841 0.25533709803439 274 5319502 SGTC_165 k038-0023 64.381 µM 0.656009454007066 0.246607244700973 no 842 0.255909020676038 285 46368543 SGTC_3331 9141060 1.957 µM 0.654536868207975 0.247080466365788 no 843 0.256382991202294 279 4906567 YPR165W RHO1 SGTC_3196 9111891 49.47 µM 0.653604268841373 0.247380412156992 no 844 0.256683396632693 310 18891510 SGTC_885 0865-0106 16.8 µM 0.650119798315221 0.248502819359728 no 845 0.257807420767801 295 2793380 SGTC_986 1493-0483 84 µM 0.647921320089716 0.249212380244383 no 846 0.258517920230584 291 40079 SGTC_2257 7960413 200 µM 0.647491674696074 0.24935117444207 no 847 0.258656890470858 280 2974689 YIL048W NEO1 SGTC_479 n-linoleoylglycine 10 µM 0.646817617808692 0.249569006986755 no 848 0.258874994336605 294 6433346 An anti-infammatory. SGTC_1702 st027038 51 µM 0.64657801461256 0.249646463040319 no 849 0.258952545402819 279 5521182 SGTC_942 3253-1115 227 µM 0.64464747892564 0.250271009127089 no 850 0.259577829603964 320 46497897 SGTC_3273 9137859 49.47 µM 0.644102516258262 0.250447459391841 no 851 0.259754479393589 322 2377234 SGTC_3163 9099914 49.47 µM 0.643966739445884 0.250491432026619 no 852 0.259798501134242 318 16268368 SGTC_1081 sertraline 6 µM 0.641748187018846 0.251210510884952 no 853 0.260518348134466 291 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1 SGTC_684 1140-0066 328 µM 0.641611412442333 0.251254878059472 no 854 0.260562760553014 291 6813534 SGTC_1333 1482-0047 286 µM 0.641287745220239 0.251359886296456 no 855 0.260667874879217 294 3811116 SGTC_2119 5528445 120.635 µM 0.640414738774635 0.251643233785956 no 856 0.260951501662342 288 791935 SGTC_2036 5160441 105 µM 0.638934919898218 0.252123916552476 no 857 0.26143263500325 286 134534 YIL048W NEO1 SGTC_2151 5563267 85.4165 µM 0.636061899957322 0.253058527573081 no 858 0.262368038656712 308 5310824 SGTC_1520 flindersine 88 µM 0.635749359245463 0.253160308797012 no 859 0.262469899562931 305 68230 Flindersine is a natural alkaloid of the quinoline subtype. SGTC_1420 4'-methoxyflavone 42 µM 0.6323407203805 0.254271753953438 no 860 0.26358213030128 288 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13 SGTC_3143 9086658 49.47 µM 0.63222238819355 0.254310384087477 no 861 0.263620784959754 301 25236626 SGTC_1860 st056228 74.6 µM 0.631462978282353 0.254558370459468 no 862 0.263868924329536 323 688679 SGTC_1475 4092-1048 11.7 µM 0.631226685218908 0.25463555812337 no 863 0.263946158049287 303 2881759 SGTC_1198 1612-1005 86.7 µM 0.630033142729202 0.255025628835969 no 864 0.264336450149199 303 6998509 SGTC_3017 9080681 49.47 µM 0.629893060154801 0.255071430778559 no 865 0.264382276844017 313 16451914 SGTC_1284 0929-0043 16 µM 0.629744565618449 0.255119987826718 no 866 0.26443085984827 285 1239883 SGTC_2227 7312221 64.1025 µM 0.62651316455741 0.25617783760617 no 867 0.265489202423362 311 887188 YOR168W | YOR169C GLN4 | YOR169C SGTC_406 estrone 100 µM 0.626127425346203 0.256304268017532 no 868 0.265615682453298 295 5870 A steroid. SGTC_543 3844-1095 191 µM 0.624075447124198 0.256977373497011 no 869 0.266289018849339 306 4230703 SGTC_2131 toluylene red 5.2905 µM 0.62309971354837 0.257297763343936 no 870 0.266609498980423 264 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain. SGTC_1311 1190-0148 100 µM 0.62306552965283 0.257308991659787 no 871 0.266620730231108 310 1961333 SGTC_984 1492-0255 2.91 µM 0.622921733864578 0.257356226763643 no 872 0.266667977511271 297 1585198 SGTC_2528 xanthyletin 44.79 µM 0.619969042256514 0.258327144049412 no 873 0.267639084359399 321 65188 An natural product with antifungal activity of unknown mechanism. SGTC_2962 9082311 13.18 µM 0.619659047503991 0.258429187903595 no 874 0.267741141423539 311 16459453 SGTC_1242 0402-0103 60.1 µM 0.619371304961719 0.258523925475042 no 875 0.267835890118253 301 432868 SGTC_3199 9111318 49.47 µM 0.61520469706703 0.259897770317375 no 876 0.269209773109873 285 8548020 SGTC_1379 2144-0755 36.5 µM 0.615083439600189 0.259937808549086 no 877 0.26924980900637 311 5392327 SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM 0.613668310506181 0.260405307794254 no 878 0.269717266581094 301 2724278 An inhibitor of dopamine biosynthesis. SGTC_49 0717-0965 32.132 µM 0.613152981657086 0.260575658316465 no 879 0.269887595330275 320 5889349 YGL099W LSG1 SGTC_2996 9066192 71.4286 µM 0.613082252672437 0.260599043435331 no 880 0.269910977185786 290 6472854 SGTC_919 tnp00227 403.569 nM 0.612525053969882 0.260783307772864 no 881 0.270095213493255 329 1269246 A methoxyflavone. YNL221C POP1 SGTC_623 k072-0108 16.9 µM 0.612059560788118 0.260937296680912 no 882 0.270249175825364 307 5382803 SGTC_125 0133-0007 11.75 µM 0.611582182424121 0.261095265856729 no 883 0.270407114759226 304 26541 SGTC_839 0122-0028 230 µM 0.611366446334051 0.261166671165801 no 884 0.270478505408802 318 759448 SGTC_2112 5488546 200 µM 0.611167911150791 0.261232392107174 no 885 0.270544212313475 321 600757 SGTC_1904 st060225 78 µM 0.610503730291837 0.26145231710995 no 886 0.270764086553282 280 66595 SGTC_1319 1306-0155 43.7 µM 0.607033923056589 0.262602790880406 no 887 0.271914199842063 304 3122360 SGTC_3304 9125678 46.087 µM 0.605797466577477 0.263013384292182 no 888 0.272324626118645 302 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2 SGTC_2167 5876490 200 µM 0.604249156032681 0.263527998223432 no 889 0.272839002081964 303 686534 SGTC_1430 4049-0248 69.1 µM 0.604041600146898 0.263597022873706 no 890 0.27290799240709 310 22774488 SGTC_3205 9113483 49.47 µM 0.60224531222243 0.264194780347368 no 891 0.27350542885642 315 17018033 SGTC_3221 9128209 49.47 µM 0.601926315140327 0.264301006347105 no 892 0.27361159335412 315 16460723 SGTC_755 1995-0008 37.3 µM 0.601469053834839 0.264453312239305 no 893 0.27376380872344 276 689533 SGTC_980 1473-0395 201 µM 0.600971075875308 0.264619230945266 no 894 0.273929625677751 318 768876 SGTC_2563 tomatine 8.54 µM 0.600388994718573 0.264813238660059 no 895 0.274123510268295 356 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties. SGTC_1907 st060210 83.7 µM 0.599988618613014 0.264946726022803 no 896 0.274256910321182 313 688793 SGTC_1146 3579-1023 7 µM 0.599730517693224 0.265032796261746 no 897 0.274342923143742 327 X1146 SGTC_1900 st060200 72.8 µM 0.597870416732364 0.265653513479966 no 898 0.274963200309581 296 688945 SGTC_2342 7990637 118.86 µM 0.594321201102435 0.266839931400442 no 899 0.276148650549212 325 2033102 YER133W GLC7 SGTC_3050 9093513 49.47 µM 0.594261248885329 0.266859994962696 no 900 0.27616869632204 311 25236664 SGTC_3110 9122132 49.47 µM 0.592886754896497 0.267320191001589 no 901 0.27662847135092 284 918317 SGTC_3054 9094397 49.47 µM 0.590875910598637 0.267994164882838 no 902 0.277301783852402 323 2598354 SGTC_1231 0242-0792 125 µM 0.589748077194529 0.268372554507051 no 903 0.277679778878458 318 3707635 SGTC_1739 st037196 92.5 µM 0.589051510113413 0.268606387845072 no 904 0.277913360014753 326 612214 SGTC_880 0833-0487 87.2 µM 0.588795613106686 0.268692316625673 no 905 0.277999194515335 315 76075 SGTC_79 0052-0007 94.094 µM 0.587527524286751 0.269118337442127 no 906 0.278424735211813 287 2801472 SGTC_3091 9116372 49.47 µM 0.587229222820593 0.269218602539854 no 907 0.278524884243562 297 17169793 SGTC_1751 st044839 27.194 µM 0.586330000425147 0.269520962534974 no 908 0.278826887159633 286 5291326 SGTC_336 4111-0029 111 µM 0.585657068432865 0.269747344548961 no 909 0.279052994878113 319 3131175 SGTC_703 3875-0075 71.8 µM 0.585168243437892 0.269911850554522 no 910 0.279217297833613 331 2850814 SGTC_2248 tofa 1.1 µM 0.584426810914989 0.270161463276196 no 911 0.279466596473418 309 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_337 1315-0038 354 µM 0.584225175383562 0.270229366415029 no 912 0.279534412924061 314 1626437 SGTC_2925 9010536 32.5 µM 0.583462498415557 0.2704862840294 no 913 0.279790997722613 277 2994177 SGTC_2419 paclitaxel 166.5 µM 0.58345022919042 0.270490418074068 no 914 0.279795126349622 323 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_1382 3002-2117 298 µM 0.582093874716845 0.27094762845762 no 915 0.280251725388635 340 1497314 SGTC_3243 9134147 49.47 µM 0.5813353038283 0.271203501384244 no 916 0.280507245666656 311 24282180 SGTC_28 pentachloropyridine N-oxide 1.606 µM 0.579389645065549 0.271860340222331 no 917 0.281163144759696 304 140250 A respiratory chain inhibitor. SGTC_547 1120-0019 610 nM 0.578718996389676 0.272086929140071 no 918 0.281389398003134 294 3676939 SGTC_1778 st046819 58.9 µM 0.57746884372185 0.272509562846794 no 919 0.28181138989081 324 671715 SGTC_1005 4092-0690 4.4 µM 0.573837002836336 0.273739209561553 no 920 0.283039053190254 328 1529343 SGTC_32 0928-0142 34.1 µM 0.573511533196549 0.273849538948434 no 921 0.283149196195119 318 2244242 SGTC_2446 5162541 200 µM 0.571120023778727 0.274660898904651 no 922 0.283959143048615 306 1549321 SGTC_2678 equilin 100 µM 0.570415359213488 0.274900194186242 no 923 0.284198007315499 281 3247 Equilin is an estrone commonly used hormone replacement therapy SGTC_2053 5265679 138 µM 0.568198836945012 0.275653566649877 no 924 0.284949980559322 323 764595 SGTC_792 4534-1957 155 µM 0.567224592975992 0.275985022688639 no 925 0.285280800717237 310 1717904 SGTC_1501 4491-0275 38.4 µM 0.566900733991713 0.276095248910464 no 926 0.285390812735748 327 5104718 SGTC_340 k038-0059 454 µM 0.564236479510787 0.277002854008716 no 927 0.28629660219503 326 23733424 SGTC_421 streptovitacin 30 mM 0.564090096726682 0.277052763072833 no 928 0.286346408737886 327 91467 include heat shock SGTC_1307 1187-1599 12.2 µM 0.564007292739675 0.277080996958381 no 929 0.286374584502965 321 1538471 SGTC_247 mechlorethamine 29.705 µM 0.5637559364686 0.277166711167737 no 930 0.286460121719877 310 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links. SGTC_855 0428-0020 25 µM 0.563523597334324 0.277245951939339 no 931 0.286539198134749 300 6812414 SGTC_1607 st000305 50.6 µM 0.562783344559798 0.27749849383008 no 932 0.286791211532141 332 5457690 SGTC_1353 1498-1206 8.11 µM 0.561869247926332 0.277810498699335 no 933 0.287102553630709 293 6756808 SGTC_1498 4478-3555 97.6 µM 0.561868736247597 0.277810673396501 no 934 0.287102727953734 303 3437919 SGTC_1224 0823-0416 294 µM 0.561745418136651 0.277852778184785 no 935 0.287144742468782 321 3598164 SGTC_2415 st077333 57.7 µM 0.561545929102785 0.277920896782958 no 936 0.287212714601013 339 2766255 SGTC_452 diindolylmethane 8 µM 0.561052357682978 0.278089469357102 no 937 0.287380922492722 331 3071 Inhibits expression of several cancer promoting factors. SGTC_3064 1327-0027 10 µM 0.558730322982595 0.278883197202479 no 938 0.288172890710861 307 16000455 YPR107C YTH1 SGTC_653 0203-0016 55.2 µM 0.556064310525782 0.279795862155675 no 939 0.289083445936479 333 295302 SGTC_1915 st067105 30.6 µM 0.553537878378692 0.280662079082909 no 940 0.289947575334128 320 69751 YOR207C | YOR116C RET1 | RPO31 SGTC_2986 9022445 71.43 µM 0.552742331461416 0.280935110005014 no 941 0.290219931130128 338 6459286 SGTC_1989 st071868 50.2 µM 0.552683776743486 0.280955210997809 no 942 0.290239982094941 330 16414057 SGTC_2793 7325131 81.82 µM 0.552594425683536 0.280985885271561 no 943 0.290270579939979 322 4176441 SGTC_2068 5226020 147 µM 0.547582574699487 0.282709042983246 no 944 0.291989278516076 323 1810509 SGTC_1824 st053723 68.6 µM 0.547577859970195 0.282710666373304 no 945 0.291990897552091 324 675225 SGTC_3214 9129694 49.47 µM 0.546177053597771 0.283193194583382 no 946 0.292472118859671 347 17158655 SGTC_908 3448-7491 47.7 µM 0.544541396273419 0.283757120159846 no 947 0.293034484971395 285 1203031 SGTC_3069 9117009 49.47 µM 0.544370702745275 0.283816001139172 no 948 0.29309320113136 299 41904981 SGTC_1563 conessine 56.1 µM 0.543780836104457 0.284019521510813 no 949 0.293296148913272 348 441082 An anti-amoebic, histamine inhibitor. SGTC_1033 k072-0102 21.3 µM 0.542834200156937 0.284346283064529 no 950 0.293621981757796 319 5965931 SGTC_3119 9125183 49.47 µM 0.542821089461814 0.284350809899693 no 951 0.293626495645765 299 22695334 SGTC_2204 7233102 200 µM 0.54197515894292 0.284642963911506 no 952 0.293917809379859 326 2172480 SGTC_533 1222-0222 6.71 µM 0.541945422918647 0.284653236272873 no 953 0.293928052028449 345 3982874 SGTC_333 3486-0131 40.1 µM 0.541351221532673 0.28485854127077 no 954 0.294132760791184 323 6744690 SGTC_961 1252-1571 372 µM 0.540915066162147 0.285009284075499 no 955 0.294283062919302 350 6813498 SGTC_655 k060-0012 42 µM 0.539794450040163 0.285396762620946 no 956 0.294669397475276 351 5994525 SGTC_1884 5633444 25 µM 0.539647303865858 0.285447660389441 no 957 0.294720143771243 324 5724239 SGTC_179 1273-0063 6.77 µM 0.536226019466783 0.286632297261655 no 958 0.295901176476977 355 3108139 SGTC_2807 7945238 51.95 µM 0.534920857767639 0.287084829624855 no 959 0.296352292327627 338 17148797 SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM 0.532749631936698 0.287838396829587 no 960 0.297103452177225 332 689007 SGTC_1880 MG-132 525 µM 0.532102965316461 0.288063015797923 no 961 0.297327341864754 332 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1 SGTC_3178 9107506 49.47 µM 0.529559996458157 0.288947114673846 no 962 0.298208518202294 327 8897194 SGTC_146 3448-8650 53.125 µM 0.529446605819133 0.288986566239668 no 963 0.298247837421319 364 2891488 YIL048W NEO1 SGTC_2614 arthonioic acid 13.39 µM 0.529352917388067 0.289019164804408 no 964 0.298280326504362 312 6710684 SGTC_1801 st050089 28.441 µM 0.528062378629731 0.289468379215846 no 965 0.298728020780692 307 5008493 YIL048W | YNL267W NEO1 | PIK1 SGTC_985 1493-0307 8.71 µM 0.527257935828838 0.289748557774996 no 966 0.299007240414905 347 3278274 SGTC_903 1134-0042 114 µM 0.526801728157764 0.289907506401885 no 967 0.299165641346951 324 701009 SGTC_405 ebelactone b 50 µM 0.524936951914503 0.290557643272336 no 968 0.299813510290737 321 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).  SGTC_1386 3228-0095 33.8 µM 0.524796473178117 0.290606647495653 no 969 0.299862341764938 343 870181 SGTC_2624 nerol 100 µM 0.523443433784718 0.291078835959653 no 970 0.300332852743227 350 637566 A natural product oil. SGTC_3220 9131269 49.47 µM 0.523201129945613 0.29116343382807 no 971 0.300417147598284 319 17722206 SGTC_2894 9048625 32.47 µM 0.522940918457238 0.291254296749069 no 972 0.300507684229513 359 4092861 SGTC_1608 st001473 40.5 µM 0.522763451384202 0.291316273843161 no 973 0.300569438266513 369 7292267 SGTC_246 cycloheximide 667 µM 0.521763799701681 0.29166549863861 no 974 0.300917398669945 324 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells. SGTC_2309 7664088 163.95 µM 0.521744064899456 0.291672394886107 no 975 0.300924269820526 347 704922 SGTC_1752 st044819 83.042 µM 0.52111027074508 0.291893912116606 no 976 0.301144978255787 317 441209 YML126C ERG13 SGTC_1874 staurosporine 7.6 µM 0.521089547462681 0.291901156428401 no 977 0.301152196030767 328 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1 SGTC_1391 3442-0225 151 µM 0.520679019474631 0.29204468341952 no 978 0.301295196133726 336 5227075 SGTC_1448 4255-0083 152 µM 0.517824229810859 0.293043669782151 no 979 0.302290455666765 359 5399660 SGTC_1462 k081-0014 26.5 µM 0.517612924583824 0.293117675513399 no 980 0.302364181176204 313 3270634 SGTC_852 0418-0143 439 µM 0.515696708092251 0.29378919010284 no 981 0.303033127082023 321 5369229 SGTC_496 calpeptin 138 µM 0.512014302698148 0.295081638135146 no 982 0.304320499800353 321 73364 A calpain inhibitor. SGTC_2256 7954252 200 µM 0.511812249235648 0.295152630439581 no 983 0.304391208328688 346 2972920 SGTC_3280 9140961 49.47 µM 0.510656480482846 0.295558865550808 no 984 0.304795809623991 346 4901226 SGTC_1506 4226-2149 212 µM 0.508411424594344 0.296348702275957 no 985 0.305582421203959 342 991114 SGTC_2640 pentamidine 10.38 µM 0.507957687034139 0.296508449899696 no 986 0.305741508750637 330 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_1730 st033808 45.1 µM 0.507928334747628 0.29651878533352 no 987 0.305751801388445 342 1045166 SGTC_142 0335-0849 62.6745 µM 0.507831637673517 0.296552835167509 no 988 0.305785710154646 317 3889043 YPR107C YTH1 SGTC_1205 4161-2785 76 µM 0.506891302782902 0.296884047625933 no 989 0.30611554421716 309 3498106 SGTC_1315 1237-0019 3.69 µM 0.506411672168923 0.29705305221628 no 990 0.306283841145212 318 825140 SGTC_1491 4138-0063 26.5 µM 0.504559516621848 0.297706097890548 no 991 0.306934124967781 348 23883227 SGTC_2580 diallyl disulphide 81.36 µM 0.504114478424506 0.297863110054397 no 992 0.307090466617102 317 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.  SGTC_201 4262-0159 12.803 µM 0.503007029680415 0.29825398845908 no 993 0.307479664897599 344 1341029 SGTC_2597 laccaic acid a 100 µM 0.502485023879148 0.29843831342531 no 994 0.307663192187629 352 5491415 A textile dye. SGTC_1004 4084-0029 199 µM 0.500957956854818 0.298977831983977 no 995 0.308200356142485 354 716894 YLR208W SEC13 SGTC_1265 0819-1001 68.8 µM 0.498988866900519 0.299674171985924 no 996 0.308893613572572 376 3106768 SGTC_2499 avocadenofuran 51.48 µM 0.498819339825552 0.299734157103217 no 997 0.308953330854743 341 6857792 A insecticide and lysyl oxidase inhibitor. SGTC_457 grayanotoxin iii 135 µM 0.496343535131081 0.300610809727675 no 998 0.309826027824941 333 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity. SGTC_777 1315-0167 517 µM 0.495966759678179 0.300744322798571 no 999 0.309958931669239 331 4221767 SGTC_1378 2093-0007 380 nM 0.494981671361271 0.301093522240211 no 1000 0.310306529233531 367 3618014 SGTC_3150 9097574 49.47 µM 0.494616252497608 0.301223104344551 no 1001 0.310435513795629 356 17217476 SGTC_1485 3909-9022 254 µM 0.492112134054182 0.302111771149084 no 1002 0.311320037389717 348 714516 SGTC_1938 st074717 56.4 µM 0.492087983778341 0.302120347377795 no 1003 0.311328573249052 328 17250979 SGTC_3089 9117425 49.47 µM 0.491469631254624 0.302339973500362 no 1004 0.311547163063134 361 9401657 SGTC_1471 k673-0312 37 µM 0.490075420137472 0.302835431253887 no 1005 0.312040265332863 325 24099884 SGTC_993 3909-8757 62.7 µM 0.489592691177742 0.303007062276597 no 1006 0.312211074695212 333 4288324 YLR208W SEC13 SGTC_538 2922-0838 53.3 µM 0.489200609485133 0.303146496300309 no 1007 0.31234983904079 319 777039 SGTC_3328 9140624 29.0385 µM 0.488446435987917 0.303414779846507 no 1008 0.312616828632296 339 4904392 SGTC_1281 0884-0031 11.8 µM 0.488342413233037 0.303451792378825 no 1009 0.312653662088995 347 1548255 SGTC_2306 7482397 179.52 µM 0.486169719219193 0.304225323260322 no 1010 0.313423419363574 375 891448 SGTC_1920 st075728 45.7 µM 0.483790476848647 0.305073396291025 no 1011 0.314267287143059 375 3400306 SGTC_2648 atorvastatin 78.68 µM 0.483128042683322 0.305309705432757 no 1012 0.314502411888434 362 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11 SGTC_1615 st002656 86.5 µM 0.481715244258712 0.305813961936966 no 1013 0.315004122657648 328 1584458 SGTC_1888 azatryptophan 97.5 µM 0.480993534865377 0.306071696924853 no 1014 0.315260546826143 319 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides SGTC_481 bay k-8644 50 µM 0.480718019566245 0.306170113569404 no 1015 0.315358461212124 360 2303 A calcium channel antagonist. SGTC_119 0121-0043 24.815 µM 0.478458278123929 0.306977841794277 no 1016 0.316162031442056 349 1092378 SGTC_1940 st075990 51.1 µM 0.478353511142815 0.307015312769147 no 1017 0.316199307976413 337 1084979 SGTC_2095 5432005 200 µM 0.478309739977552 0.307030968568014 no 1018 0.316214882495204 366 783734 SGTC_769 0302-0231 76 µM 0.478026306358525 0.307132353861152 no 1019 0.316315740847778 363 571869 YER009W NTF2 SGTC_1415 3966-0071 78.1 µM 0.476826564210919 0.307561669474274 no 1020 0.316742814017251 349 2893185 SGTC_1690 st023502 41.2 µM 0.476464340537684 0.307691339414239 no 1021 0.316871803119463 368 24207482 SGTC_2155 5570423 76 µM 0.476395011523478 0.307716160767037 no 1022 0.316896493959905 361 797402 SGTC_867 0518-0118 155 µM 0.476116652859679 0.307815828315037 no 1023 0.316995636845175 346 6848158 SGTC_1797 st048695 56.8 µM 0.475391706404742 0.308075465141498 no 1024 0.317253902371374 369 592262 YIL048W NEO1 SGTC_315 k915-0449 187 µM 0.474758425142907 0.308302351060597 no 1025 0.317479584601793 349 20970215 YNL149C PGA2 SGTC_2016 5121758 140 µM 0.473981709365327 0.30858072533044 no 1026 0.317756475194444 340 2795203 SGTC_2064 5220758 200 µM 0.473770190502572 0.30865655258299 no 1027 0.317831897000448 328 788518 SGTC_2646 retinol 96.75 µM 0.472525105112942 0.309103067688724 no 1028 0.318276013298616 361 445354 A vitamin A analog and teratogen. SGTC_2272 7805186 180 µM 0.470041416626089 0.309994615586312 no 1029 0.319162713858834 383 2956062 YPR165W RHO1 SGTC_1716 st033144 30.6155 µM 0.469383664459398 0.310230910643342 no 1030 0.319397711324899 382 674617 SGTC_316 k060-0003 58.6 µM 0.469330563216026 0.310249990490623 no 1031 0.319416686162415 359 6152314 SGTC_594 1487-1584 10.8 µM 0.469269930748586 0.310271777012185 no 1032 0.319438352734625 356 5013332 SGTC_1223 0764-0573 147 µM 0.468630605469104 0.31050154055336 no 1033 0.319666848492705 336 1609797 SGTC_1170 0310-0127 64.8 µM 0.466252150857377 0.311356968849482 no 1034 0.320517512129934 382 774975 SGTC_1842 st055362 61.2 µM 0.46573740243995 0.311542236183437 no 1035 0.320701738295534 341 676032 SGTC_3032 9089427 49.47 µM 0.465638461266061 0.311577852384273 no 1036 0.320737153963209 341 17173707 SGTC_357 1325-0123 420 µM 0.464869693267983 0.311854648539592 no 1037 0.321012387510542 371 1098503 SGTC_2878 9043973 25.97 µM 0.464255677291997 0.312075802349395 no 1038 0.321232287567709 356 6465167 SGTC_1031 k035-0009 16 µM 0.461683723102841 0.31300289398987 no 1039 0.32215407260899 371 5180959 SGTC_1507 4075-3230 155 µM 0.459106701654934 0.313932999575121 no 1040 0.323078772188993 375 659771 SGTC_402 epigallocatechin gallate 10 µM 0.456762788039914 0.314779999285167 no 1041 0.32392077762221 361 65064 An antioxidant. SGTC_20 0481-0013 4.944 µM 0.456288491311485 0.314951510566858 no 1042 0.324091269347703 352 182045 SGTC_3211 9128781 49.47 µM 0.454608424247773 0.315559363486343 no 1043 0.324695486535177 367 17194361 SGTC_154 3389-1638 511.116 µM 0.453451976655527 0.315978059723481 no 1044 0.325111658218707 381 5238686 SGTC_1459 k035-0031 35.7 µM 0.451751611940624 0.316594112039288 no 1045 0.325723966096384 339 3877128 YMR208W ERG12 SGTC_2141 5621638 7.665 µM 0.451155578589801 0.316810179091198 no 1046 0.325938711445607 353 2856238 SGTC_3149 9097855 49.47 µM 0.45000488557379 0.317227491653416 no 1047 0.326353458908778 340 25236625 YMR079W SEC14 SGTC_648 0375-0473 33.3 µM 0.449024336694417 0.317583282922123 no 1048 0.32670705038964 367 1713139 SGTC_1022 4477-0945 21.3 µM 0.447361397645939 0.318187064052804 no 1049 0.327307071464041 355 4648966 SGTC_2370 9071495 200 µM 0.447183593397928 0.318251649984812 no 1050 0.327371253177817 372 21791103 SGTC_487 nimodipine 119 µM 0.44586995171372 0.318728990645344 no 1051 0.327845594333683 367 4497 L-type voltage-gated calcium channels inhibitor SGTC_1097 itavastatin 7.23 µM 0.445395398176636 0.318901504165391 no 1052 0.32801701861468 361 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49 SGTC_2593 nobiletin 86.24 µM 0.444912502893575 0.319077090428565 no 1053 0.328191493405162 324 72344 An anti-infammatory. SGTC_385 1494-0393 12.4 µM 0.443598602031425 0.319555045287035 no 1054 0.328666408319338 362 3090647 SGTC_3068 9116768 49.47 µM 0.442962741513447 0.319786458621098 no 1055 0.328896342202758 378 41904888 SGTC_3258 9138477 49.47 µM 0.441877257693447 0.320181668721085 no 1056 0.329289014251891 369 4970355 SGTC_1652 st011932 78 µM 0.441553982993889 0.320299408165433 no 1057 0.329405994785726 363 1551076 SGTC_846 0335-0850 148 µM 0.440260131326536 0.32077082116716 no 1058 0.329874356425215 360 6819598 SGTC_924 2046-0044 21.3 µM 0.437828159492188 0.321657688757861 no 1059 0.330755428161679 342 3623589 SGTC_2495 cafestol 54.53 µM 0.437078327862401 0.321931335399847 no 1060 0.331027271915118 368 16667697 An anti-infammatory. SGTC_1282 0886-0010 32.4 µM 0.437008707610789 0.321956747803778 no 1061 0.331052516544741 388 2836211 YNL267W PIK1 SGTC_735 3076-0345 636 µM 0.436948365203298 0.32197877433332 no 1062 0.33107439760595 350 2888990 SGTC_608 k048-0125 159 µM 0.436859668374123 0.322011152090782 no 1063 0.33110656145262 361 6817652 YLR060W | YFL022C FRS1 | FRS2 SGTC_628 1636-0253 16 µM 0.436799299017386 0.322033190002959 no 1064 0.331128453711645 364 4456143 SGTC_1401 3807-4679 7.6 µM 0.436601108986842 0.322105543930807 no 1065 0.331200329125137 368 3291456 SGTC_681 1642-0006 26.6 µM 0.435952261252564 0.322342468203677 no 1066 0.331435683146133 383 4446530 SGTC_572 0960-0087 17.7 µM 0.435793348916662 0.322400505444679 no 1067 0.331493334954743 369 6796365 SGTC_2936 9038235 15.59 µM 0.434488909112038 0.322877070521917 no 1068 0.331966723484528 342 4749415 SGTC_1947 st076332 61.6 µM 0.43448651848504 0.322877944182856 no 1069 0.331967591303064 360 24208416 SGTC_489 paxilline 115 µM 0.433554062130515 0.323218787320135 no 1070 0.332306149829513 355 105008 A toxic potassium channel blocker. SGTC_1634 st006576 41 µM 0.432880630599713 0.323465040801171 no 1071 0.332550746141588 383 3915356 SGTC_710 3448-4187 58 µM 0.431984150987823 0.323792976199597 no 1072 0.332876466137536 350 3946412 SGTC_870 0573-2213 57.6 µM 0.43178762080907 0.323864885927608 no 1073 0.332947888766916 340 3916321 SGTC_3186 9110464 49.47 µM 0.431756595265313 0.323876238670134 no 1074 0.332959164565914 375 17018021 SGTC_2975 9084847 53.72 µM 0.430569765090468 0.324310641736491 no 1075 0.333390614677905 333 27211724 SGTC_1744 st037937 38.9 µM 0.430421814221341 0.324364811431704 no 1076 0.333444414943662 345 1016152 SGTC_2159 5658611 73.75 µM 0.428410681001941 0.325101521942037 no 1077 0.334176074856035 378 793844 SGTC_2143 5623677 140.463 µM 0.428144406429569 0.325199113967434 no 1078 0.334272994152841 360 5375313 SGTC_287 k060-0039 29.6 µM 0.42788919665825 0.325292661898189 no 1079 0.334365896425868 357 5861974 SGTC_1937 st074714 47.2 µM 0.427175567480648 0.325554303303583 no 1080 0.334625727823214 358 17250970 SGTC_420 mitomycin C 81.9 mM 0.42489868036043 0.326389663988027 no 1081 0.335455268350102 353 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_1649 st011737 51.3 µM 0.421072457055466 0.327795417657426 no 1082 0.336851086603245 354 1761035 SGTC_1064 honokiol 6.76 µM 0.420373673931229 0.328052414933358 no 1083 0.337106248422566 367 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis. SGTC_900 1112-0045 141 µM 0.419476840468056 0.328382370135047 no 1084 0.337433838483803 355 56211 YIL048W NEO1 SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM 0.418732069124702 0.328656481746019 no 1085 0.337705977881166 336 6857784 SGTC_1850 st056238 17 µM 0.418525885986318 0.328732383344961 no 1086 0.33778133219319 371 5393177 SGTC_3035 9091303 49.47 µM 0.418247709875529 0.328834798703605 no 1087 0.33788300827717 357 25237002 SGTC_2949 9072542 2.23 µM 0.415130692844264 0.329983260022163 no 1088 0.33902311588611 366 16457352 SGTC_3145 9085516 49.47 µM 0.415057971641885 0.330010073256292 no 1089 0.339049732691513 361 25236195 SGTC_3021 9087658 49.47 µM 0.414722665325867 0.330133716262917 no 1090 0.339172469091354 374 25237042 SGTC_1093 fluphenazine 7.97 µM 0.414003984213187 0.330398789845752 no 1091 0.339435594487717 388 6602611 An atypical antipsychotic. SGTC_649 1123-0311 367 µM 0.413291036149069 0.330661832997752 no 1092 0.339696698252442 374 693629 YIL048W NEO1 SGTC_2847 9005661 71.43 µM 0.412347806315654 0.331009967458177 no 1093 0.340042256589612 363 2991449 SGTC_1347 1493-0251 600 nM 0.411224212544034 0.331424862766117 no 1094 0.340454067840848 356 3986378 SGTC_542 3381-0244 89.3 µM 0.410933523632869 0.331532235514671 no 1095 0.340560639989459 401 1112843 SGTC_136 0097-0015 404.482 µM 0.408828316496643 0.332310255778362 no 1096 0.341332828938038 348 4861337 SGTC_603 3794-0023 45.9 µM 0.407498154760205 0.332802216006024 no 1097 0.341821074564463 369 3802260 SGTC_3018 9082602 49.47 µM 0.407059443403837 0.332964536571949 no 1098 0.341982164875247 365 17332089 SGTC_95 0471-0001 561.058 µM 0.407010005496583 0.332982830263747 no 1099 0.342000319771975 344 4015405 SGTC_629 3448-6466 76.7 µM 0.406807137935729 0.333057902260007 no 1100 0.342074821888077 389 573744 SGTC_1175 0741-0056 27.6 µM 0.40397498896888 0.334106648465035 no 1101 0.343115555651452 374 765927 SGTC_181 1447-1644 8.07 µM 0.402519657723117 0.334646063259817 no 1102 0.343650812115998 380 534600 SGTC_3206 9114350 49.47 µM 0.401578567895144 0.334995057661269 no 1103 0.343997102708901 371 17087243 SGTC_258 haloperidol 50.781 µM 0.399294767378442 0.335842575949765 no 1104 0.344838011120131 376 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_2126 5251174 33.877 µM 0.398355241283188 0.336191476862802 no 1105 0.345184172934727 360 790722 SGTC_1280 0880-0253 10.1 µM 0.398017839114968 0.336316808457504 no 1106 0.345308518038978 384 6836607 SGTC_3334 9142812 21.919 µM 0.397431457153637 0.336534669500267 no 1107 0.345524661075633 374 45283678 SGTC_759 3486-0358 89.3 µM 0.396387571112187 0.336922644812251 no 1108 0.345909566808312 395 875103 SGTC_2604 4'-hydroxychalcone 11.32 µM 0.394325971123344 0.337689377784131 no 1109 0.346670195626153 353 5282362 SGTC_427 1354-0053 47.3 µM 0.39430994581952 0.337695340425244 no 1110 0.346676110600158 386 6813657 SGTC_429 1112-0049 25.5 µM 0.394093756049508 0.337775783568722 no 1111 0.346755910360591 341 2836170 SGTC_2866 9034245 58.44 µM 0.394042252179885 0.337794948996939 no 1112 0.346774922422478 410 6462273 SGTC_667 1498-1044 59 µM 0.390389664999581 0.339155206114652 no 1113 0.348124214476342 399 6739982 SGTC_118 0083-0097 135.343 µM 0.390083148032708 0.339269451569877 no 1114 0.348237531832925 382 5207356 SGTC_1711 st032263 62.8 µM 0.389759056874172 0.339390263376338 no 1115 0.348357360992685 398 3958979 SGTC_3126 9127922 49.47 µM 0.389019030444123 0.339666185688993 no 1116 0.348631034395695 418 45595682 SGTC_3006 9075424 71.4286 µM 0.387427343172939 0.340259944800988 no 1117 0.349219932202173 393 7465181 SGTC_1782 st039423 80.636 µM 0.385833375467428 0.340854951778898 no 1118 0.349810037775359 375 2068169 SGTC_809 3998-0021 90 µM 0.384853603571097 0.341220884295197 no 1119 0.350172941078413 402 715485 SGTC_597 k018-0003 82.8 µM 0.384683623978454 0.341284384755489 no 1120 0.350235914729945 404 6786234 SGTC_2586 curcumin 80 µM 0.384440808751468 0.341375102726376 no 1121 0.350325879503332 362 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40 SGTC_3133 9127736 49.47 µM 0.383617817130401 0.341682648019833 no 1122 0.350630866214525 383 27243420 SGTC_1361 1608-0041 5.61 µM 0.382657440364492 0.342041665928941 no 1123 0.350986887273911 371 X1361 SGTC_413 propylparaben 100 µM 0.382057477449164 0.34226602275194 no 1124 0.351209365822544 364 7175 A pharmaceutical preservative. SGTC_355 1311-2252 105 µM 0.381580567253947 0.342444403598023 no 1125 0.351386250287479 377 5338538 SGTC_3152 9099253 49.47 µM 0.38138575590261 0.342517279870265 no 1126 0.351458514456979 365 25236131 SGTC_2473 5854593 8.94 µM 0.380934098388263 0.342686261342339 no 1127 0.351626074909295 385 2872951 SGTC_2702 st077768 96.8 µM 0.380469307399585 0.342860189394949 no 1128 0.351798537851161 339 6484119 SGTC_1446 4239-0190 62 µM 0.380381101879252 0.342893200281695 no 1129 0.351831270379969 388 1340085 SGTC_2740 felodipine 17.08 µM 0.380222043840286 0.342952730731434 no 1130 0.351890298620549 405 3333 L-type calcium channel blocker SGTC_151 3013-0144 2.285 µM 0.379732764240299 0.343135877222003 no 1131 0.352071898199872 410 906558 YHR107C CDC12 SGTC_97 0535-0701 19.132 µM 0.377864633723551 0.343835492025825 no 1132 0.352765578090361 377 2832013 YGL099W LSG1 SGTC_2350 9023895 38.85 µM 0.376167140913559 0.344471667136841 no 1133 0.353396321095642 386 2997209 SGTC_139 0099-0334 718.624 µM 0.375776313667617 0.344618201192859 no 1134 0.353541599179808 378 97690 SGTC_2203 7227154 166.4 µM 0.375748987604829 0.344628447509677 no 1135 0.353551757606831 371 896304 SGTC_72 0744-0168 198.391 µM 0.374434370297514 0.345121517501151 no 1136 0.35404058791066 423 677577 SGTC_3200 9114385 49.47 µM 0.373510246995804 0.345468283462435 no 1137 0.354384360134657 348 17018030 YLR208W SEC13 SGTC_1043 0916-0009 19.3 µM 0.373313493348451 0.345542129622019 no 1138 0.354457567473851 407 3101130 SGTC_2398 5228213 48.84 µM 0.37289000072789 0.34570109606309 no 1139 0.354615157216816 401 80771 YMR134W ERG29 SGTC_436 n,n-dimethylsphingosine 3.3 µM 0.371792883488144 0.346113047496704 no 1140 0.355023531321063 398 5282309 SGTC_2061 5245884 80.95 µM 0.369333629022651 0.34703712272244 no 1141 0.35593953117585 404 573863 SGTC_804 1595-0054 20.9 µM 0.36750370667585 0.347725314846355 no 1142 0.356621663730279 387 761523 Stimulates phospholipase C. SGTC_2124 5246320 200 µM 0.36742234338814 0.347755925399992 no 1143 0.356652003855147 400 579342 SGTC_58 0957-0393 9 µM 0.366652373149591 0.348045653258984 no 1144 0.356939168319197 364 6997992 SGTC_1295 1013-0063 9.78 µM 0.366627817379694 0.34805489467515 no 1145 0.356948327858107 393 6826038 SGTC_2385 9074692 200 µM 0.364879681225254 0.348713026784459 no 1146 0.357600611107172 369 17046906 SGTC_2742 clothiapine 36.27 µM 0.361933679765863 0.349823156863103 no 1147 0.358700795459335 401 16351 An atypical antipsychotic. YIL048W NEO1 SGTC_1113 artemisinin 1.17947 µM 0.361642444271314 0.349932971935644 no 1148 0.358809621251028 398 2240 An anti-malaria and mitochondrial poison. SGTC_1680 diphenhydramine 100 µM 0.361564943605933 0.349962196935151 no 1149 0.358838582809268 406 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1 SGTC_658 3253-0951 102 µM 0.358956102124765 0.350946491725337 no 1150 0.359813964549365 410 1184878 SGTC_1453 4237-0541 195 µM 0.358701299904372 0.35104268030726 no 1151 0.359909277918354 367 739892 SGTC_1466 k213-0079 57.5 µM 0.358372376072617 0.351166864127304 no 1152 0.360032330694821 399 3657981 SGTC_642 0335-0876 158 µM 0.358121119789504 0.351261735597124 no 1153 0.360126337254606 393 6812350 SGTC_1612 st002233 45.4 µM 0.357723739546955 0.351411800706748 no 1154 0.360275032791718 395 1035021 SGTC_409 arachidonic acid 100 µM 0.356583581225168 0.351842494113634 no 1155 0.360701785394819 375 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes. SGTC_579 4491-1009 110 µM 0.356008803526 0.352059687826693 no 1156 0.360916986146738 422 1271041 SGTC_2566 crystal violet carbinol 226 nM 0.355334291921465 0.352314629978797 no 1157 0.361169584124819 425 68050 Cationic dye that binds acidic phospholipids including cardiolipin. SGTC_1425 4048-4433 7.33 µM 0.354088869566249 0.352785531079767 no 1158 0.361636141615044 429 23734946 SGTC_1630 st005209 31.3 µM 0.353697795987433 0.352933444751818 no 1159 0.361782687258466 407 3367314 SGTC_134 0269-0018 6.916 µM 0.353031905916045 0.35318535193666 no 1160 0.362032260566204 398 4378915 SGTC_232 clozapine 119 µM 0.351610175607752 0.353723409822127 no 1161 0.362565316452447 402 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_740 k014-0057 261 µM 0.351408829945954 0.353799633318413 no 1162 0.362640829476209 427 4012779 SGTC_2555 cholic acid 100 µM 0.350364943184425 0.354194911791508 no 1163 0.36303241616569 385 6708657 Influences liver metabolism. SGTC_2903 5923464 63.88 µM 0.349765076071119 0.354422128780722 no 1164 0.363257505384358 395 2876576 SGTC_255 tunicamycin 200.472 nM 0.349726260527228 0.354436833074668 no 1165 0.363272071838632 379 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_3134 9127454 49.47 µM 0.349696228662978 0.354448210041061 no 1166 0.363283342144291 394 24262820 SGTC_1822 st052468 42 µM 0.34949178222202 0.354525663905019 no 1167 0.363360069593332 375 2873678 SGTC_453 enantio-paf c16 10 µM 0.34845629326002 0.354918047840846 no 1168 0.363748766161665 420 13871343 A lipid and platelet activating factor SGTC_2671 danthron 100 µM 0.348163066920086 0.355029189812396 no 1169 0.363858861472093 386 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin. SGTC_1367 1812-0510 76.9 µM 0.348054681716757 0.355070274324045 no 1170 0.36389955882907 372 1142582 YDR527W RBA50 SGTC_66 0109-0187 42.4 µM 0.347839583935577 0.355151814311615 no 1171 0.363980330038444 358 759417 SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM 0.346940761651654 0.35549261460726 no 1172 0.364317911484922 369 4000243 SGTC_1717 st033143 58.0435 µM 0.346857179582037 0.355524311726096 no 1173 0.364349308757779 427 674616 SGTC_2565 isoliquiritigenin 100 µM 0.346255025557272 0.355752698209226 no 1174 0.364575532417586 351 638278 Binds to benzodiazepine receptor 65X better than valium. SGTC_1948 st076329 66.6 µM 0.34610978164321 0.355807794439202 no 1175 0.364630106267726 422 24208413 SGTC_29 0299-0004 12.984 µM 0.345583616397058 0.356007413016016 no 1176 0.364827830205986 403 16871 A napthoquinone isolated from Swertia calycina. SGTC_669 0108-0021 26.2 µM 0.344234025973828 0.35651960615746 no 1177 0.365335147577805 417 17201 SGTC_2478 5763493 32.33 µM 0.343382226623483 0.356843012214245 no 1178 0.365655464350584 403 1365576 YLR208W SEC13 SGTC_3270 9137563 49.47 µM 0.342109676170921 0.357326358196012 no 1179 0.366134177904337 402 17015724 SGTC_2235 salicylic acid 500 µM 0.341108905907491 0.35770663627897 no 1180 0.366510798469428 377 338 A COX inhibitor and kinase inhibitor. SGTC_1924 st058459 75.1 µM 0.337872687800853 0.35893731736872 no 1181 0.367729565207617 404 688683 SGTC_2365 9042475 200 µM 0.337743115753277 0.358986622109114 no 1182 0.367778390157744 382 6464479 SGTC_940 3232-1287 54.8 µM 0.335904530025465 0.359686493353 no 1183 0.368471430441461 415 1585493 YIL048W NEO1 SGTC_2270 7924575 90.91 µM 0.335622222463621 0.359793997567118 no 1184 0.368577882003259 400 1262135 SGTC_1777 st045864 34.765 µM 0.334438203582902 0.360244998970697 no 1185 0.369024457537208 425 4691462 SGTC_1970 st070122 35.8 µM 0.33425099515829 0.360316325850153 no 1186 0.369095083009463 417 102928 SGTC_495 decylubiquinone 155 µM 0.334236857986373 0.36032171234559 no 1187 0.369100416519688 425 2971 A Co-enzyme Q analog. A free radical scavenger. SGTC_773 4358-1457 44.6 µM 0.333881982263467 0.360456934923741 no 1188 0.369234308219914 417 1186886 SGTC_806 3966-4455 5.86 µM 0.333368986843313 0.360652438606929 no 1189 0.369427885225045 390 714982 SGTC_3261 9137475 49.47 µM 0.33264392099764 0.360928824914164 no 1190 0.369701542710269 404 17027690 SGTC_3016 9080866 49.47 µM 0.332241620789422 0.36108220821644 no 1191 0.369853409075702 414 17066299 SGTC_957 1187-1561 14.1 µM 0.332085734515967 0.361141648324555 no 1192 0.369912260841398 413 1538454 SGTC_2300 7976697 71.57 µM 0.329460479561427 0.362143172027058 no 1193 0.370903830382459 384 2236109 SGTC_1732 st034308 51.822 µM 0.327406860894373 0.362927277745933 no 1194 0.371680088966545 373 830119 SGTC_1481 3346-2004 36 µM 0.324286007378416 0.364119971476463 no 1195 0.372860756142394 425 2770522 SGTC_82 0054-0107 293.755 µM 0.323048137254346 0.364593412694749 no 1196 0.373329393274133 384 3104697 SGTC_2305 7443522 69.23 µM 0.322830523831044 0.364676663449026 no 1197 0.373411797503302 410 5415886 SGTC_2880 9042983 58.44 µM 0.32250407607717 0.364801562113017 no 1198 0.373535425160872 407 6464714 SGTC_371 0195-0006 7.36 µM 0.322383667218675 0.36484763407446 no 1199 0.373581027980419 386 3928593 SGTC_2859 9028643 45.46 µM 0.3219192136345 0.365025365917856 no 1200 0.373756948501854 404 17151580 SGTC_2417 cerulenin 830 nM 0.321443084680661 0.365207595664771 no 1201 0.373937318593798 423 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1 SGTC_2874 9043904 71.43 µM 0.321200561646507 0.365300428674676 no 1202 0.374029203272614 400 4463428 SGTC_323 4013-0906 34.3 µM 0.321050802143213 0.36535775758604 no 1203 0.374085946216409 409 2910086 SGTC_2472 5377652 49.4 µM 0.31907585042051 0.366114062944649 no 1204 0.374834497927185 415 1610903 SGTC_1351 1496-0003 46.5 µM 0.318721779899078 0.366249708922961 no 1205 0.374968748680052 406 3891978 SGTC_104 0074-0074 590.992 µM 0.318336659078029 0.366397269385293 no 1206 0.375114789786833 394 3943124 SGTC_1016 4226-1401 38 µM 0.316339804795243 0.367162687780354 no 1207 0.375872300669134 422 2901613 SGTC_2460 5552655 174.22 µM 0.316174464203266 0.367226088549917 no 1208 0.375935044465999 381 5401989 SGTC_416 estradiol valerate 100 µM 0.315490454564394 0.367488414302047 no 1209 0.376194648724164 412 13791 A steroid. SGTC_3042 9091578 49.47 µM 0.31510254029091 0.367637211485493 no 1210 0.376341899912263 392 25236497 SGTC_716 1683-5115 658 µM 0.314866615085133 0.367727718019481 no 1211 0.376431465273575 436 723597 SGTC_596 1155-0152 116 µM 0.314769163842623 0.367765104783623 no 1212 0.376468463075032 399 280313 SGTC_2116 5511452 16.8835 µM 0.314459345702733 0.367883973547672 no 1213 0.376586094459943 426 870744 SGTC_124 0136-0217 7.121 µM 0.314384454044682 0.367912709332267 no 1214 0.376614530956519 393 3976905 SGTC_859 0439-0102 54.6 µM 0.3139459593008 0.368080973749641 no 1215 0.376781041627308 414 610143 SGTC_1179 1021-1431 9.29 µM 0.313539646719891 0.368236911439986 no 1216 0.37693535215017 425 2840958 SGTC_577 r071-0003 38.6 µM 0.313363416716195 0.368304553064488 no 1217 0.377002287385519 410 4568517 YMR134W ERG29 SGTC_830 4076-0286 57.8 µM 0.313064978544614 0.368419110647465 no 1218 0.377115647848285 398 6866659 SGTC_2214 7179297 48.276 µM 0.312276630119928 0.368721779951565 no 1219 0.37741514954507 413 769744 SGTC_26 0302-0163 425.158 µM 0.312266478923917 0.368725677814963 no 1220 0.377419006570363 429 3100915 SGTC_2215 7188065 200 µM 0.311719660483136 0.368935665492816 no 1221 0.377626792516972 422 940217 SGTC_43 0570-0105 72.5 µM 0.309362151182389 0.369841436851813 no 1222 0.378523029071721 420 1114046 YDL195W SEC31 SGTC_2616 abietic acid 100 µM 0.306770684320065 0.370837929955784 no 1223 0.379508961780049 427 6708678 Abietic acid is an inhibitor of 5α-reductase. SGTC_2216 7189485 200 µM 0.306292055103579 0.371022071616599 no 1224 0.379691143916644 415 731273 SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM 0.305931275054307 0.371160893027654 no 1225 0.379828486412654 420 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1 SGTC_2088 5278280 127.392 µM 0.303360011340964 0.372150751747391 no 1226 0.38080775847998 387 791502 SGTC_320 4092-0846 5.34 µM 0.300974181365324 0.373069980504594 no 1227 0.381717091253964 405 1359356 SGTC_1086 cerivastatin 2.18 µM 0.300828055508932 0.373126304416825 no 1228 0.381772806788518 407 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7 SGTC_3222 9128301 49.47 µM 0.300497292415319 0.373253806387924 no 1229 0.381898930697803 430 4911358 SGTC_3344 9148862 3.898 µM 0.300230505383203 0.373356657093625 no 1230 0.38200066890683 415 4905352 SGTC_1383 3049-0032 20.7 µM 0.299603575732632 0.373598384093856 no 1231 0.38223977818316 435 712864 SGTC_3158 9100007 49.47 µM 0.299392486852653 0.373679785415034 no 1232 0.382320297024154 387 19297233 SGTC_271 rotenone 740 µM 0.298876004351843 0.373878978156304 no 1233 0.382517328248596 426 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria. SGTC_2045 5106652 78.05 µM 0.298674534862476 0.373956688395436 no 1234 0.382594194436201 440 673349 SGTC_1449 4112-4002 201 µM 0.29767045657216 0.374344054954446 no 1235 0.382977347014089 401 2059539 SGTC_2376 9072922 81.32 µM 0.29458801360014 0.375534031552506 no 1236 0.384154309904721 419 17087968 SGTC_324 1315-0088 19.6 µM 0.294369655443699 0.375618373763447 no 1237 0.384237725827113 442 6787421 SGTC_2890 9046729 58.44 µM 0.292027104781691 0.376523571875318 no 1238 0.385132950084639 408 903329 SGTC_2574 2',4'-dihydroxychalcone 14.64 µM 0.289669730910937 0.377435183860747 no 1239 0.386034457587776 449 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_2251 lansoprazole 556 µM 0.289404322499828 0.377537861928951 no 1240 0.386135993792613 419 3883 Gastric proton pump inhibitor. YBR192W RIM2 SGTC_731 3966-0296 387 µM 0.289239778409589 0.377601523148207 no 1241 0.386198946665773 413 660956 SGTC_2025 5147754 141 µM 0.289005979924062 0.377691984237493 no 1242 0.386288400709586 435 315777 YLR208W SEC13 SGTC_3167 9103034 49.47 µM 0.288609302802368 0.377845481520024 no 1243 0.386440187856202 394 5127859 SGTC_1099 5-nonyloxytryptamine 2.85 µM 0.287355713334414 0.378330694364981 no 1244 0.38691998372199 408 23581825 A 5-HT1D beta serotonin receptor agonist. SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM 0.287182920286801 0.378397590503418 no 1245 0.386986131695631 415 17037758 SGTC_297 0986-0032 24 µM 0.285469235805261 0.379061233626933 no 1246 0.387642335253261 423 2847425 SGTC_2679 rapamycin 1 nM 0.285213953302468 0.379160125145457 no 1247 0.387740115476238 410 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2 SGTC_2783 7738165 71.43 µM 0.284536850696511 0.379422459928966 no 1248 0.387999498875485 418 17201110 SGTC_2156 5649887 115 µM 0.283232715259545 0.379927886965182 no 1249 0.388499225759111 428 54680440 YKL052C | YBR257W ASK1 | POP4 SGTC_2686 alizarin 95.37 µM 0.283127080991326 0.379968835276436 no 1250 0.388539711460809 372 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1 SGTC_2008 4012253 172 µM 0.282376787404641 0.380259719510881 no 1251 0.388827306016613 418 603940 SGTC_1620 st003704 16.5 µM 0.282309257943463 0.380285903594834 no 1252 0.388853193682636 430 2834414 SGTC_719 2810-4230 27.3 µM 0.280919990881796 0.380824703913566 no 1253 0.389385883654003 432 721079 SGTC_2850 9015429 58.44 µM 0.280651682313487 0.380928788863345 no 1254 0.389488785832486 430 6457570 SGTC_42 0133-0086 60.653 µM 0.279666343430725 0.381311105275416 no 1255 0.389866751180194 463 162923 Model of phenazepam hydroxylation. SGTC_3080 9117754 49.47 µM 0.279448715951468 0.381395561458417 no 1256 0.389950244785781 420 9550191 SGTC_1250 0485-0349 40.2 µM 0.279292498871085 0.381456189170831 no 1257 0.390010181190489 406 6842794 YDL195W SEC31 SGTC_2747 doxorubicin 7.63 µM 0.278530134862123 0.381752103687811 no 1258 0.390302717802118 432 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_1029 k015-0030 64.7 µM 0.277319006861156 0.382222349723949 no 1259 0.390767583161242 410 2208316 SGTC_1594 piperine 70.1 µM 0.277250991911633 0.382248763125022 no 1260 0.390793693869496 425 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_3108 9121785 49.47 µM 0.276167826549463 0.38266948090781 no 1261 0.391209583659549 438 17140271 SGTC_1959 st077091 55.8 µM 0.274054995665916 0.383490534488658 no 1262 0.392021179212715 414 821356 YKL052C ASK1 SGTC_569 4130-2812 160 µM 0.273513254311779 0.383701141568723 no 1263 0.392229352587075 424 743552 SGTC_2976 9009005 19.48 µM 0.272639371546957 0.384040944160157 no 1264 0.392565221966043 432 2993148 SGTC_2458 5808907 16.39 µM 0.272619041915136 0.384048850243343 no 1265 0.39257303643994 443 2731747 SGTC_1584 6-fluoro-dl-tryptophan 90 µM 0.272037935707994 0.384274859675029 no 1266 0.39279642520431 401 94937 An inhibitor of serotonin biosynthesis. SGTC_1554 st069299 38.7 µM 0.270630344670713 0.384822476525926 no 1267 0.393337677391634 400 24207999 SGTC_1052 3253-3998 198 µM 0.270511843527401 0.384868589358235 no 1268 0.393383253321188 405 5450317 SGTC_978 1416-0512 87.4 µM 0.27013211081533 0.385016367262198 no 1269 0.393529309610625 416 6814003 SGTC_345 1362-0200 395 µM 0.269105765079809 0.385415866524291 no 1270 0.393924147069386 401 1419823 SGTC_559 1550-0661 158 µM 0.26905168832015 0.385436918972848 no 1271 0.393944953545679 433 5830875 SGTC_2970 9090938 41.86 µM 0.268665026996799 0.385587458675684 no 1272 0.394093733474923 417 17217104 SGTC_766 1391-0721 126 µM 0.267499540314599 0.386041324362661 no 1273 0.394542284027798 448 1020919 YIL115C NUP159 SGTC_2352 9027995 87.8 µM 0.266139097509758 0.386571307486982 no 1274 0.395066042495328 425 2997347 SGTC_98 0074-0023 107.663 µM 0.265827803867491 0.38669260689306 no 1275 0.395185914496799 434 3563821 SGTC_1158 4092-0494 91.8 µM 0.263972720357595 0.387415692232931 no 1276 0.395900469697275 433 1148199 SGTC_1037 k284-1091 78.7 µM 0.263724135331228 0.387512616906833 no 1277 0.395996248214466 437 3334711 SGTC_1993 st073995 70.8 µM 0.26300012239415 0.38779495347528 no 1278 0.396275242389092 417 3098394 SGTC_290 2043-6722 48.1 µM 0.262566772990116 0.387963971093001 no 1279 0.396442256487365 433 773758 YLR208W SEC13 SGTC_2818 7996756 12.99 µM 0.262144038113202 0.388128869220447 no 1280 0.396605198028717 449 2241621 SGTC_1623 st003709 20.3 µM 0.261988512431193 0.388189540911942 no 1281 0.396665149353247 397 16192618 SGTC_2675 theaflavin digallate 100 µM 0.261979865309401 0.38819291429668 no 1282 0.396668482677679 422 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative. SGTC_112 phenothiazine 287.218 µM 0.260975633602635 0.388584738950598 no 1283 0.397055648924128 460 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.  SGTC_1240 0356-0016 42.1 µM 0.258643377411754 0.389495160478217 no 1284 0.397955205695874 431 4305613 SGTC_278 4092-0821 23.9 µM 0.258181920910356 0.389675367102009 no 1285 0.398133255036172 431 877900 SGTC_1303 1160-0052 261 µM 0.257921495780792 0.389777078024677 no 1286 0.39823374737876 451 3562476 SGTC_279 1273-0055 2.93 µM 0.257326278452868 0.390009572800282 no 1287 0.398463454018469 438 2847562 SGTC_2364 9055074 200 µM 0.25453075144234 0.391102044375666 no 1288 0.399542774979598 420 6470630 SGTC_2547 epiafzelechin trimethyl ether 100 µM 0.254306120488724 0.391189865948741 no 1289 0.39962953586959 433 6708630 An antioxidant. SGTC_1058 3448-5425 97.3 µM 0.253876652638142 0.391357785863163 no 1290 0.399795426236312 451 7279705 SGTC_1505 k297-0037 20.6 µM 0.25212384344073 0.392043335700211 no 1291 0.400472670370535 405 4089396 SGTC_933 2914-0560 114 µM 0.25180810150561 0.392166862781258 no 1292 0.400594697483345 407 463887 SGTC_2245 6637752 200 µM 0.250841568158222 0.392545065179572 no 1293 0.400968301009761 434 681890 SGTC_293 4049-0273 38.5 µM 0.248710044313996 0.393379484094511 no 1294 0.401792539349503 424 1380311 SGTC_2800 7887935 81.82 µM 0.247821197454014 0.393727582317563 no 1295 0.402136376617169 426 2961002 SGTC_3008 9078912 71.4286 µM 0.246383924094672 0.39429063988637 no 1296 0.402692524728122 448 16648731 SGTC_2409 alverine citrate 63.97 µM 0.246067998199158 0.39441443478041 no 1297 0.402814797640014 362 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_3174 9107204 49.47 µM 0.245077874506265 0.394802481691574 no 1298 0.403198067092272 414 3938802 SGTC_2519 cryptotanshinone 88.04 µM 0.244711479804066 0.394946104709175 no 1299 0.403339919329614 416 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE) SGTC_1541 2',3',6-trimethoxyflavone 64 µM 0.244239263128481 0.395131229924036 no 1300 0.403522760031659 417 688801 SGTC_1922 5578187 25 µM 0.24085154509832 0.396460023906262 no 1301 0.404835089039803 452 1350412 SGTC_2304 7443016 91.4 µM 0.239015361906117 0.397180749911928 no 1302 0.405546835425032 452 939854 SGTC_977 1348-1378 135 µM 0.238836883782442 0.39725082368776 no 1303 0.405616034303593 460 X977 SGTC_678 1218-2179 85.9 µM 0.23401675713854 0.399144540840345 no 1304 0.407485984756063 474 6820081 YOR116C RPO31 SGTC_2282 7944268 200 µM 0.233457189453754 0.399364536917662 no 1305 0.407703204494835 434 2970414 SGTC_1287 0971-0001 34.6 µM 0.233041786136165 0.399527874922336 no 1306 0.407864479126113 418 4665869 SGTC_2136 5328288 199.296 µM 0.232583775048863 0.399707986831897 no 1307 0.408042313735041 426 262395 SGTC_575 k072-0246 11.9 µM 0.232293542339684 0.399822131292282 no 1308 0.408155013872991 446 6796779 SGTC_588 3970-1144 52.9 µM 0.231671097855816 0.400066958847905 no 1309 0.408396740632405 432 1888707 SGTC_473 2-arachidonoylglycerol 10 µM 0.230761405326793 0.400424840989339 no 1310 0.408750083053745 454 5282280 An endocannabinoid. SGTC_3168 9103419 49.47 µM 0.229833022725723 0.400790162205763 no 1311 0.409110761547627 464 16649256 SGTC_2522 biochanin a 4.94 µM 0.229495409377146 0.400923035561842 no 1312 0.409241944107226 447 5280373 A possible chelator. SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM 0.228290868048538 0.401397196163206 no 1313 0.409710061689407 433 6708784 An antioxidant flavonoid SGTC_3049 9092223 49.47 µM 0.22796700832867 0.401524706437681 no 1314 0.409835944388668 446 8623917 SGTC_2937 9044753 11.33 µM 0.227812043204532 0.401585723124377 no 1315 0.409896181867702 437 6465530 YGL099W LSG1 SGTC_350 k064-0020 19.8 µM 0.227788209258892 0.401595107825613 no 1316 0.409905446701028 425 2790705 SGTC_2775 cyproheptadine 69.59 µM 0.227698458571159 0.401630447988735 no 1317 0.409940335423669 463 2913 A selective serotonin reuptake inhibitor. SGTC_3037 9091026 49.47 µM 0.227567943088154 0.401681841102461 no 1318 0.40999107188916 436 25236398 YIL048W NEO1 SGTC_1057 3448-5381 134 µM 0.225438862414503 0.402520449233026 no 1319 0.410818940905297 441 5497911 SGTC_1227 3909-8010 46.6 µM 0.225365214243971 0.402549466028673 no 1320 0.410847585298656 439 15982272 SGTC_2786 7743617 45.45 µM 0.224464635216035 0.402904330405677 no 1321 0.411197890925798 427 583674 SGTC_2413 inermin 26.06 µM 0.224224816821103 0.402998842003328 no 1322 0.411291187009869 467 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1 SGTC_1160 4092-0570 10.5 µM 0.223742883186292 0.403188787510611 no 1323 0.411478687881206 454 4994975 SGTC_1344 1488-0097 29.1 µM 0.223034901142633 0.40346786736695 no 1324 0.411754171696358 458 747966 SGTC_2724 maprotiline 69.64 µM 0.220814952389142 0.404343268414568 no 1325 0.41261826030997 455 4011 A tricyclic antidepressant. SGTC_377 3970-0964 33.1 µM 0.219959841339172 0.404680595758453 no 1326 0.412951215354337 433 16481235 SGTC_3195 9113082 49.47 µM 0.219740857212964 0.404766992825966 no 1327 0.413036491402602 474 17018038 SGTC_954 1189-0853 2.85 µM 0.219033582738931 0.405046069588322 no 1328 0.413311943815823 425 2828194 SGTC_2798 7813637 45.45 µM 0.218806948655343 0.405135505217308 no 1329 0.413400216894262 469 956368 SGTC_1480 1070-0044 41.2 µM 0.218274937702762 0.405345469858575 no 1330 0.413607450245774 434 3124987 SGTC_923 1900-2434 73.3 µM 0.217459815199929 0.40566722077021 no 1331 0.413925010239067 482 5910570 SGTC_383 2324-0395 7.37 µM 0.216514703550427 0.406040361706595 no 1332 0.414293282595745 449 3146421 SGTC_157 1348-1695 65.819 µM 0.216044158066919 0.406226170322433 no 1333 0.414476663546429 444 5380510 SGTC_2451 5856223 45.7 µM 0.215004407740259 0.406636820924198 no 1334 0.414881941022403 441 2179896 SGTC_1098 clofazimine 15.1 µM 0.214712534378282 0.406752115127141 no 1335 0.414995724736144 445 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2 SGTC_607 4491-0986 66.8 µM 0.214401073270187 0.406875155687776 no 1336 0.415117152388154 434 698981 YDR232W HEM1 SGTC_2891 9063876 19.48 µM 0.213886134548919 0.407078598831422 no 1337 0.415317926533333 457 6472478 SGTC_717 1532-0246 73.2 µM 0.213497622114657 0.407232109792605 no 1338 0.415469421821988 417 9561992 SGTC_116 0155-0182 31.788 µM 0.212137254333511 0.407769737218547 no 1339 0.415999978150075 430 771486 SGTC_931 2812-0076 566 µM 0.211302150201857 0.408099862685462 no 1340 0.416325752592833 467 3450959 SGTC_1122 capsaicin 818.572 nM 0.211115056142421 0.408173831893986 no 1341 0.416398745947892 463 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_2168 5727979 200 µM 0.210592174721517 0.408380574802068 no 1342 0.416602759524172 451 695210 SGTC_1039 k821-0043 94 µM 0.210527903111452 0.408405989016402 no 1343 0.416627838044408 451 15992768 SGTC_2773 thioridazine 9.09 µM 0.210089350797488 0.408579411201123 no 1344 0.416798968421758 468 5452 An antipsychotic. SGTC_1270 0831-1170 17.3 µM 0.209505239131598 0.408810421524728 no 1345 0.417026922950559 453 6764716 SGTC_1046 2001-0062 216 µM 0.207535037863175 0.409589849640837 no 1346 0.41779601600652 453 739778 SGTC_1018 4259-0013 28.1 µM 0.206456615629522 0.410016634088334 no 1347 0.418217125189256 435 6801262 SGTC_127 0180-0333 59.125 µM 0.206048957081595 0.410177992319472 no 1348 0.418376334743531 441 771601 SGTC_1693 xanthone 101.9 µM 0.20582610870305 0.410266205953407 no 1349 0.418463373017663 462 7020 An insecticide. SGTC_718 1130-0073 349 µM 0.205657470306454 0.410332963802514 no 1350 0.418529241059936 446 6740020 SGTC_1866 st057638 64 µM 0.205427292798997 0.410424086955778 no 1351 0.418619149193621 456 688802 SGTC_1126 isoteolin 1.0172 µM 0.204735301118502 0.410698063174427 no 1352 0.41888946913124 423 133323 SGTC_1434 4073-0095 163 µM 0.203125505605788 0.411335588485018 no 1353 0.419518468339378 463 24133745 SGTC_3346 9158254 43.5805 µM 0.202853144241046 0.411443474626995 no 1354 0.419624909128751 473 17639500 SGTC_3248 9135562 49.47 µM 0.202658590924471 0.411520544014652 no 1355 0.419700945571945 418 17650701 SGTC_1603 st002045 67.8 µM 0.202097227278193 0.411742938957709 no 1356 0.419920357727848 452 5887985 SGTC_2898 9056270 58.44 µM 0.201857681201915 0.411837848351957 no 1357 0.420013993248172 453 19154699 SGTC_1473 k844-0725 134 µM 0.201697868627098 0.411901169789265 no 1358 0.420076464473237 461 54682906 SGTC_902 1120-0002 2.07 µM 0.200536370614685 0.412361450983375 no 1359 0.420530558010457 444 3280475 SGTC_1320 1313-0481 95.3 µM 0.200375226963605 0.412425318910348 no 1360 0.420593566307198 462 6813365 YLR208W SEC13 SGTC_391 gliotoxin 8.33 µM 0.199895647296415 0.412615409981089 no 1361 0.420781097348985 445 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion SGTC_1851 st056236 18.9 µM 0.199726178200929 0.412682587377535 no 1362 0.420847369505565 450 5393171 SGTC_492 tmb-8 126 µM 0.199656115067685 0.412710361087664 no 1363 0.42087476887305 465 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1 SGTC_2310 7668677 200 µM 0.199483004692052 0.412778985604367 no 1364 0.420942468242194 473 2197143 SGTC_2656 pseudo-anisatin 100 µM 0.198231042254329 0.413275368519592 no 1365 0.421432150582393 475 6708809 A neurotoxin. SGTC_3086 9117350 49.47 µM 0.197857890467682 0.413423344043771 no 1366 0.421578125663162 457 2679265 SGTC_2918 7977171 22.06 µM 0.197800795427575 0.413445986501289 no 1367 0.421600461903615 452 2236483 SGTC_551 k048-0028 34.9 µM 0.195339920332644 0.414422180294808 no 1368 0.422563423533583 457 6836383 SGTC_1994 st072947 40.9 µM 0.195276978022552 0.414447155566618 no 1369 0.422588059498543 474 5286565 YDL195W SEC31 SGTC_2569 tetrandrine 100 µM 0.194569365814184 0.414727957208658 no 1370 0.422865043608728 416 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_199 4063-0024 41.6 µM 0.193990448957265 0.414957721111682 no 1371 0.423091680237748 470 306215 SGTC_1210 3013-0140 750 nM 0.19355775568815 0.415129469945689 no 1372 0.423261089312286 458 905973 SGTC_2848 9016370 25.97 µM 0.193430949864805 0.415179806025035 no 1373 0.423310739312771 470 7894410 SGTC_2394 5221648 200 µM 0.192444302414566 0.415571507180809 no 1374 0.423697096287196 454 788586 SGTC_2995 9067767 71.4286 µM 0.189236345400062 0.416845650995918 no 1375 0.424953791375787 439 11673567 SGTC_3234 9132280 49.47 µM 0.188638721337405 0.417083113684903 no 1376 0.425187991189369 432 17612295 SGTC_2641 levomentholum 100 µM 0.188078675525406 0.417305672319063 no 1377 0.425407488623332 485 16666 SGTC_2779 methotrexate 400 µM 0.186795280213223 0.417815785255101 no 1378 0.425910573815002 476 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2 SGTC_2829 7992743 58.44 µM 0.183832205471946 0.418994049657681 no 1379 0.427072545179723 476 16462845 SGTC_2466 5983409 37.09 µM 0.183265407702151 0.419219519508533 no 1380 0.427294887670597 466 2879657 SGTC_2123 5259487 200 µM 0.182395353063219 0.419565675304912 no 1381 0.427636236179411 465 2173474 SGTC_760 0568-0725 82.9 µM 0.182010294233227 0.419718892865759 no 1382 0.427787323606127 484 3916171 SGTC_3036 9090181 49.47 µM 0.180948972218734 0.420141263141557 no 1383 0.42820381449515 448 25236586 SGTC_2165 5727197 32.143 µM 0.17985510341885 0.420576682195877 no 1384 0.428633161310513 464 1361712 SGTC_1002 4049-0206 172 µM 0.17957320655577 0.420688908194937 no 1385 0.428743820392886 453 4662749 SGTC_797 k781-0471 270 µM 0.179379011333654 0.420766223032164 no 1386 0.428820055309504 455 23738129 SGTC_826 1683-5028 118 µM 0.177826144964632 0.421384574558683 no 1387 0.429429756936556 448 722377 SGTC_1024 4507-0395 26 µM 0.177786894743271 0.421400206519606 no 1388 0.429445169931351 427 4201836 SGTC_2140 5586273 200 µM 0.17683196498786 0.421780559039068 no 1389 0.429820190133256 473 854421 SGTC_1019 4262-0212 3.4 µM 0.175178521251861 0.422439304987773 no 1390 0.430469680457159 487 4677213 SGTC_2371 9071574 200 µM 0.173867641604945 0.422961724824105 no 1391 0.430984741756509 480 45596039 SGTC_15 0266-0086 27.098 µM 0.173112628930902 0.423262678685241 no 1392 0.431281449185633 481 1712902 YIL048W NEO1 SGTC_1296 1068-0102 11.9 µM 0.171918238255896 0.423738863383956 no 1393 0.431750904004064 478 767053 SGTC_2111 5486399 200 µM 0.171794234965772 0.42378830793148 no 1394 0.431799648987177 454 689674 SGTC_486 niguldipine 82 µM 0.170306626669088 0.424381563894776 no 1395 0.432384500032604 459 1236 A calcium channel blocker. SGTC_1184 1269-1718 139 µM 0.170001110572603 0.424503424511792 no 1396 0.432504631626738 454 5403821 SGTC_348 k064-0012 10.7 µM 0.168740029094256 0.425006505901775 no 1397 0.433000565776543 454 5066323 SGTC_1413 3910-0535 34.4 µM 0.168379946081785 0.425150175746869 no 1398 0.433142191782446 479 2876951 SGTC_2607 solasodine 47.35 µM 0.167012995227858 0.425695667041692 no 1399 0.433679911913495 456 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity. SGTC_2842 9000675 19.48 µM 0.166881556323895 0.425748126167801 no 1400 0.433731622778003 489 2989072 SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM 0.165448095089958 0.426320325956842 no 1401 0.434295650414345 490 756377 SGTC_1490 4089-0339 670 nM 0.164232671557649 0.426805612450763 no 1402 0.434773991053174 471 742542 SGTC_2681 menadione 3.18 µM 0.163923501056259 0.426929073768913 no 1403 0.434895683089737 480 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_3233 9132340 49.47 µM 0.163216894014104 0.427211270615392 no 1404 0.435173832535216 488 17682950 SGTC_2297 7971671 152.32 µM 0.162747071813797 0.427398923597714 no 1405 0.435358791542889 460 909016 SGTC_40 0327-0103 19.753 µM 0.161970121269236 0.427709283585325 no 1406 0.435664691461318 454 409036 SGTC_1687 st020778 55.3625 µM 0.16072606257362 0.428206327275301 no 1407 0.436154580667528 484 4259299 SGTC_2982 9019404 25.97 µM 0.160519830288471 0.428288735104926 no 1408 0.436235800928138 401 22333232 SGTC_1416 3966-0321 25.3 µM 0.158734461317665 0.429002276460981 no 1409 0.436939043091405 461 582530 YLR208W SEC13 SGTC_2457 5731572 11.68 µM 0.157405592951035 0.429533523374885 no 1410 0.437462602933431 479 2865357 SGTC_2435 5706476 10.6 µM 0.155640036076306 0.430239544252347 no 1411 0.438158382624029 476 5725375 SGTC_943 3253-1379 105 µM 0.154577050879518 0.430664724528058 no 1412 0.438577381628134 487 668464 SGTC_2642 cholecalciferol 100 µM 0.154522374207847 0.430686596664676 no 1413 0.43859893550714 465 9821465 A vitamin D precursor, similar to steriods. SGTC_1765 st044815 90.4 µM 0.154228940193966 0.430803981779132 no 1414 0.438714612102978 480 645695 SGTC_1633 st005664 67.9 µM 0.153551454709465 0.431075025880615 no 1415 0.438981708192398 458 2063822 SGTC_2852 9023854 51.95 µM 0.151839517263744 0.431760071352132 no 1416 0.439656756603956 504 19798528 SGTC_2144 5628481 200 µM 0.15134382768834 0.431958463916363 no 1417 0.439852248966808 480 2818399 SGTC_128 0906-2981 13.371 µM 0.150958153908534 0.432112836126815 no 1418 0.440004362935183 477 6740226 SGTC_1872 amphotericin b 148 nM 0.150114096978325 0.432450719791961 no 1419 0.440337299115338 488 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1 SGTC_1791 st048313 56.1 µM 0.14980668460169 0.432573792048449 no 1420 0.440458567663925 492 1204976 SGTC_3208 9114115 49.47 µM 0.149483574315336 0.432703155999572 no 1421 0.440586034769895 482 650895 SGTC_1338 1486-1223 76 µM 0.149304058479254 0.432775032031642 no 1422 0.440656856483048 492 3444526 SGTC_3105 9121040 49.47 µM 0.148033565862463 0.433283785792699 no 1423 0.441158139168635 488 41448907 SGTC_2091 4-phenylthiadiazole 200 µM 0.147968978438677 0.433309652024361 no 1424 0.441183625161248 471 270010 SGTC_1650 st011916 45.8 µM 0.146909992698717 0.433733799562014 no 1425 0.441601532236613 489 242528 SGTC_1084 voriconazole 435 nM 0.146673753098068 0.433828429248837 no 1426 0.441694768252587 504 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_2339 9000433 200 µM 0.146494174544781 0.433900364951837 no 1427 0.441765644174618 461 2988954 SGTC_1292 0kpi-0043 232 µM 0.146351750986944 0.433957418637466 no 1428 0.441821857118216 488 3333905 SGTC_2079 5212404 121 µM 0.146330626673519 0.433965880977878 no 1429 0.441830194742078 461 758462 SGTC_503 tyrphostin 8 294 µM 0.144009091509348 0.434896065004485 no 1430 0.442746645243444 502 92970 A tyrosine kinase inhibitor. YOR207C RET1 SGTC_2441 5730946 39.09 µM 0.143909169207707 0.434936109626284 no 1431 0.442786097539654 457 1774275 SGTC_366 0181-0206 4.31 µM 0.143296587994064 0.435181620775642 no 1432 0.443027975205532 463 274874 SGTC_2545 solidagenone 89.61 µM 0.142276540186275 0.435590492359368 no 1433 0.443430788110484 469 6708572 An anti ulcer agent SGTC_2515 chrysin 20.77 µM 0.142066110274531 0.4356748487642 no 1434 0.443513893350695 462 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor. SGTC_1503 4585-0012 61.3 µM 0.140785344874631 0.436188340486019 no 1435 0.444019760421309 475 2922052 SGTC_2317 5986382 200 µM 0.140768904441901 0.436194932578585 no 1436 0.444026254534336 495 877883 SGTC_2840 9008771 71.43 µM 0.140601459812845 0.436262073578097 no 1437 0.444092397465837 489 2992978 SGTC_3117 9124945 49.47 µM 0.140284781041547 0.436389058658987 no 1438 0.44421749419208 483 17592065 SGTC_394 menadione 8.33 µM 0.140085565400298 0.436468945537291 no 1439 0.444296192636255 495 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_840 0245-0196 390 µM 0.139710615696316 0.436619310041172 no 1440 0.444444319281274 460 3827528 SGTC_2073 5212005 126 µM 0.135498462885939 0.438309116313296 no 1441 0.44610888974482 501 691789 SGTC_36 0335-0881 14.2 µM 0.134422944843502 0.438740767794579 no 1442 0.446534069463961 480 23828853 SGTC_2978 9011784 42.97 µM 0.134210991487154 0.438825842371317 no 1443 0.446617867299162 460 2994934 SGTC_1411 3909-8223 150 µM 0.132747063071455 0.439413516026442 no 1444 0.447196710627389 496 X1411 SGTC_2916 7875993 68.79 µM 0.132553950773433 0.439491048264758 no 1445 0.447273076451027 492 1299250 SGTC_1076 itraconazole 331 nM 0.130940745897272 0.440138820798247 no 1446 0.447911090793849 466 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1 SGTC_1256 0570-0116 285 µM 0.130829757368269 0.440183393473989 no 1447 0.447954991168112 466 410638 SGTC_734 2023-0417 80 µM 0.130806116959651 0.440192887492409 no 1448 0.447964341971634 501 3935732 SGTC_150 3970-0969 77.2 µM 0.129084046918911 0.440884565168025 no 1449 0.448645572553156 461 6615640 SGTC_1121 fusaric acid 630.51 nM 0.127295587288009 0.441603099463848 no 1450 0.449353226365198 464 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler. SGTC_1074 carmofur 3.8 µM 0.126041789494131 0.442106941955616 no 1451 0.449849422550461 489 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_936 3005-4620 401 µM 0.125387708785976 0.442369823526851 no 1452 0.450108309143471 506 777207 SGTC_580 1123-0028 41 µM 0.125374250199665 0.442375232934015 no 1453 0.450113636305061 500 1677248 YPR107C YTH1 SGTC_3293 9120939 62.045 µM 0.125246658638405 0.442426516320787 no 1454 0.450164139891155 491 934087 SGTC_3098 9119039 49.47 µM 0.124543059862012 0.442709333899003 no 1455 0.450442654456525 503 17161528 SGTC_312 4092-0653 6.84 µM 0.121604918209444 0.443890659098569 no 1456 0.451605959116543 487 1148278 SGTC_2524 avocatin b 10.57 µM 0.121198073869463 0.444054276693478 no 1457 0.451767074850891 503 6710748 SGTC_2397 5161689 200 µM 0.121020918506732 0.444125524944107 no 1458 0.451837233199731 492 2259942 SGTC_2269 7935389 174.42 µM 0.119835343110328 0.44460238540287 no 1459 0.452306791959169 475 97605 SGTC_3330 9141424 71.43 µM 0.118960970389177 0.444954125781727 no 1460 0.452653138630818 464 27261020 SGTC_1408 3909-7976 48.8 µM 0.117526712758812 0.445531188941542 no 1461 0.453221338502065 496 24152374 SGTC_687 k029-0044 34.9 µM 0.116760575295836 0.445839486167273 no 1462 0.453524893174845 500 5829338 SGTC_992 3909-8734 162 µM 0.116625244890394 0.445893947151229 no 1463 0.453578515853318 479 4288319 SGTC_2841 9004761 38.96 µM 0.116495374919855 0.445946211653531 no 1464 0.453629975710754 474 2991039 SGTC_347 4534-1311 26.2 µM 0.116424718704315 0.44597464673491 no 1465 0.453657972954763 490 2862016 SGTC_946 3434-1334 87.4 µM 0.116302398012926 0.446023874466629 no 1466 0.453706442585974 481 4047976 SGTC_403 arphamenine a 50 µM 0.115653197653498 0.446285157836074 no 1467 0.453963700056429 504 5487158 An arginine aminopeptidase inhibitor. SGTC_754 3474-0146 171 µM 0.11546054416071 0.446362699491464 no 1468 0.454040046234409 498 24762078 SGTC_2226 7298446 200 µM 0.115045821052472 0.446529629538028 no 1469 0.454204401592314 491 3283010 SGTC_213 1246-0773 967 nM 0.115017494317417 0.446541031667839 no 1470 0.454215627804143 493 6251622 SGTC_262 fenpropimorph 62.5 µM 0.11469106948462 0.446672427982446 no 1471 0.454344996367435 501 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_1810 st050138 53 µM 0.114346173092681 0.446811266044523 no 1472 0.454481690833872 513 3444541 SGTC_3345 9148410 3.559 µM 0.114185090425422 0.446876112115863 no 1473 0.454545535359633 511 4903596 SGTC_411 enrofloxacin 100 µM 0.114151268956339 0.446889727599806 no 1474 0.454558940524372 502 71188 A bacterial gyrase inhibitor. SGTC_624 k048-0052 28 µM 0.113807062343639 0.447028298160589 no 1475 0.454695370015439 470 6835531 SGTC_3198 9112019 49.47 µM 0.112543723940547 0.447536947731799 no 1476 0.45519615162087 508 45595555 SGTC_3173 9105693 49.47 µM 0.111474751425415 0.447967408486848 no 1477 0.455619943119169 482 17096658 SGTC_784 4579-0127 173 µM 0.111010240049492 0.448154480057307 no 1478 0.455804113269455 506 1948547 SGTC_407 eburnamonine 100 µM 0.11042498081189 0.448390196540221 no 1479 0.456036171224882 492 3195 SGTC_2511 berberine 10.47 µM 0.110162508419673 0.448495914710766 no 1480 0.456140247600744 489 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_2044 5102272 200 µM 0.109099458945742 0.448924125244323 no 1481 0.456561802013835 481 592666 SGTC_3306 9127676 59.7925 µM 0.107128328015856 0.449718280207878 no 1482 0.457343586987436 496 41905287 SGTC_3040 9091894 49.47 µM 0.106637782280648 0.44991594910337 no 1483 0.457538171772269 492 25236966 SGTC_745 0469-0705 296 µM 0.10566806901443 0.450306738483492 no 1484 0.457922857855017 498 3486736 SGTC_3090 9117696 49.47 µM 0.105582391895041 0.450341268237294 no 1485 0.457956847942138 507 7923821 SGTC_2213 7173844 200 µM 0.10479484325417 0.450658685147098 no 1486 0.45826930100329 489 892728 SGTC_184 1494-0393 24.714 µM 0.104071020083892 0.450950445713756 no 1487 0.458556494286343 488 3090647 SGTC_3154 9100113 49.47 µM 0.103909219991993 0.451015668154639 no 1488 0.458620695111645 476 25237525 SGTC_1218 1348-1416 30.7 µM 0.103207289130426 0.451298635351295 no 1489 0.458899227459197 494 6787668 SGTC_1613 st002381 52.1 µM 0.103177409674055 0.451310681113446 no 1490 0.458911084339349 499 551167 SGTC_889 0919-1524 82.7 µM 0.103123480273202 0.45133242261096 no 1491 0.458932484902969 468 3905452 SGTC_857 0438-0306 1.35 µM 0.102626527708163 0.451532774606144 no 1492 0.459129693966526 491 4686136 SGTC_2885 9057732 51.95 µM 0.101763499964822 0.451880743220195 no 1493 0.459472199003396 483 6471414 SGTC_1334 1486-0610 236 µM 0.100690426974709 0.45231345259495 no 1494 0.459898105459222 502 3742339 SGTC_2523 spermine 47.74 µM 0.100528068475513 0.452378927500352 no 1495 0.459962550140655 495 1103 A DNA binding polyamine. SGTC_3279 9140807 49.47 µM 0.100399933032151 0.452430602063368 no 1496 0.460013411465785 504 45595718 SGTC_2945 9067681 61.76 µM 0.0998975685484892 0.452633203773913 no 1497 0.460212823356765 507 16456930 SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM 0.0993219609057129 0.452865359333642 no 1498 0.460441321173008 493 66535 A nucleotide analog. SGTC_2007 4011539 71.82 µM 0.0986668400945629 0.453129603950278 no 1499 0.460701399063913 494 45595301 SGTC_965 1291-5240 308 µM 0.0983934794023993 0.453239870812652 no 1500 0.460809926120069 496 2834598 SGTC_2543 pimpinellin 60.67 µM 0.098357639891568 0.453254327841954 no 1501 0.460824154997631 504 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo. SGTC_56 0957-0365 83.25 µM 0.0983235855010064 0.453268064842489 no 1502 0.460837675199444 513 6752360 SGTC_1054 3429-0080 167 µM 0.0982150783095455 0.453311835293836 no 1503 0.460880754795991 503 1162877 SGTC_1134 3477-0009 42.5 µM 0.0961072105643621 0.454162234813124 no 1504 0.461717712308561 512 3973534 SGTC_1045 1348-1485 165 µM 0.0959121373440138 0.454240945963489 no 1505 0.461795177408653 485 6810614 SGTC_2246 7293507 91.5585 µM 0.0957915998327545 0.454289583195321 no 1506 0.461843044520919 516 887656 SGTC_2080 5212524 12.4 µM 0.0951132626682676 0.454563306949967 no 1507 0.46211243187493 504 260183 SGTC_2328 6201408 200 µM 0.0951084154481602 0.454565262986187 no 1508 0.462114356909254 497 2890418 SGTC_2942 9052777 62.25 µM 0.0950868355682214 0.454573971295412 no 1509 0.462122927195079 511 6469503 SGTC_50 0929-0078 56.389 µM 0.0945994273542093 0.454770665011363 no 1510 0.462316502351232 507 1377751 SGTC_2534 helenine 20.12 µM 0.0945487165388875 0.454791130012306 no 1511 0.462336642767322 508 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58 SGTC_2743 auranofin 4.32 µM 0.0925955161908844 0.455579459908652 no 1512 0.463112453003373 517 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold. SGTC_257 daunorubicin 18.5 µM 0.092547397885685 0.455598883126436 no 1513 0.463131567354094 510 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_1622 st003707 19.4 µM 0.0924066518685688 0.455655696637145 no 1514 0.463187477308243 498 10140899 SGTC_1204 4049-0315 18.3 µM 0.0916090382562528 0.455977678294362 no 1515 0.463504335080055 469 588402 SGTC_1511 0906-3109 28.5 µM 0.0905192901682002 0.456417635856328 no 1516 0.463937282770473 497 2882180 SGTC_274 sirtinol 40.1 µM 0.0896426122158913 0.456771610681086 no 1517 0.464285610523619 498 6836442 NAD-dependent acetyltransferase inhibitor. SGTC_415 dibenzyl ketone 100 µM 0.087832661799038 0.457502519612033 no 1518 0.465004838856332 515 7593 SGTC_89 0302-0250 142.109 µM 0.0873992343478812 0.457677571246476 no 1519 0.465177088976585 513 4203518 YLR208W SEC13 SGTC_968 1309-0633 340 µM 0.0868822498680451 0.457886380426882 no 1520 0.465382554357218 516 3761976 SGTC_2837 9008476 45.46 µM 0.0868235762929926 0.457910079322822 no 1521 0.465405873607421 512 2992805 SGTC_3272 9137413 49.47 µM 0.0865963555573776 0.45800185766355 no 1522 0.465496181431689 489 17614870 SGTC_3001 9076041 71.4286 µM 0.0857027919828506 0.458362804944866 no 1523 0.465851341307876 489 16004211 SGTC_344 k064-0035 6.43 µM 0.085181477492249 0.458573401305299 no 1524 0.466058557937257 507 5088750 SGTC_2349 9023730 187.07 µM 0.0843138007743024 0.458923943997903 no 1525 0.466403470021062 496 4126287 SGTC_2752 diclazuril 33.15 µM 0.0827666950153051 0.459549056118737 no 1526 0.467018525881349 496 456389 An antifungal agent for coccidioides. YHR062C RPP1 SGTC_1297 1068-0111 14.1 µM 0.0822828229629949 0.459744586489575 no 1527 0.467210906693867 516 767057 SGTC_619 1652-1634 108 µM 0.0776633718136829 0.461611767948023 no 1528 0.469047915563189 499 5400454 SGTC_2615 purpurogallin-4-carboxylic acid 100 µM 0.0766530883940338 0.46202023858724 no 1529 0.469449762359497 504 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase. SGTC_2217 6934799 96.0675 µM 0.0762938572301242 0.462165490065173 no 1530 0.469592656411032 513 675606 SGTC_389 tpck 16.7 µM 0.0752240009457574 0.462598105419538 no 1531 0.470018244229871 481 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.  SGTC_2907 7721985 69.9 µM 0.0751595582682997 0.462624165376503 no 1532 0.470043880564633 496 3267881 SGTC_2343 7990716 14.84 µM 0.074115238249237 0.463046499953663 no 1533 0.470459345119774 516 6456862 SGTC_2505 galangin 7.89 µM 0.0732823844147002 0.463383345145463 no 1534 0.470790704603196 519 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_1648 st011736 69.8 µM 0.0716152062747345 0.464057708894077 no 1535 0.471454069145913 505 2855514 SGTC_741 4582-0002 126 µM 0.0708504801288003 0.464367070787685 no 1536 0.47175837770211 522 2912688 SGTC_2808 7946468 45.46 µM 0.0699409218732214 0.464735051017552 no 1537 0.472120340957909 508 2970879 SGTC_1395 3486-0190 4.35 µM 0.0697404043059837 0.464816178532788 no 1538 0.472200141034645 512 6748079 SGTC_24 0417-1663 219 µM 0.0692697530840945 0.465006605314685 no 1539 0.472387450715373 505 4329390 SGTC_679 0422-0091 41.4 µM 0.0690646118252625 0.465089608544014 no 1540 0.472469094706593 520 627384 YHR062C RPP1 SGTC_3159 9100096 49.47 µM 0.0688187521706293 0.465189089047695 no 1541 0.472566945700382 506 25236875 SGTC_196 k015-0023 18.111 µM 0.0667066484675314 0.466043784046807 no 1542 0.473407620696085 520 5211998 SGTC_534 k292-0788 63.4 µM 0.0664292564931175 0.466156046664377 no 1543 0.473518039163091 517 4146317 SGTC_1092 toremifene 6.32 µM 0.0654222825001192 0.466563599176421 no 1544 0.473918891606225 523 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_1145 3546-0597 10.2 µM 0.0651131952450864 0.466688703091594 no 1545 0.474041937221159 511 875334 SGTC_313 3474-0040 5.03 µM 0.0624061725456734 0.467784517237835 no 1546 0.475119689781316 520 1043375 YIL048W NEO1 SGTC_1949 st076024 69.1 µM 0.0615011377919413 0.468150933977121 no 1547 0.475480054148255 524 2921930 SGTC_952 1185-0122 232 µM 0.0607510303458097 0.468454646562759 no 1548 0.475778745180496 522 678600 SGTC_1308 1187-1617 41.4 µM 0.0605733124037494 0.468526605851946 no 1549 0.475849514050464 532 2882570 SGTC_2501 sodium tetradecyl sulfate 13.37 µM 0.0600593463988579 0.468734720209663 no 1550 0.476054184178375 524 23665772 A membrane-active detergent. SGTC_3326 9140064 16.379 µM 0.0594915871287092 0.468964626386629 no 1551 0.476280283054579 516 1868434 SGTC_1715 st032160 10.2275 µM 0.0594591642769366 0.468977755880166 no 1552 0.476293195043874 522 5289825 SGTC_1899 st063254 59.6 µM 0.0593687002855848 0.469014389060378 no 1553 0.476329221312077 521 3093813 SGTC_2072 5231554 129 µM 0.0590617661228198 0.469138683279708 no 1554 0.47645145583421 528 789545 SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM 0.0590484245800109 0.469144086059237 no 1555 0.476456769066679 522 2374 Ca(2+)-ATPase inhibitor. SGTC_1758 st042942 75.2445 µM 0.057768177602245 0.469662560044097 no 1556 0.476966643213128 528 669317 SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM 0.0575808781961701 0.469738416828294 no 1557 0.477041240693258 513 688761 SGTC_1886 st057356 49.9 µM 0.0571682304656772 0.46990554418681 no 1558 0.477205592585933 511 24207747 SGTC_1336 1486-0901 104 µM 0.0546130836529959 0.470940526702718 no 1559 0.47822335753412 519 5006114 SGTC_3315 9136395 68.55 µM 0.0543642115953872 0.471041344910672 no 1560 0.478322495839318 532 16876844 SGTC_471 1-acyl-paf 4 µM 0.0530006049162678 0.47159377550242 no 1561 0.478865712869569 517 16759367 SGTC_1827 berberine 7.24 µM 0.0524486031638133 0.471817420585576 no 1562 0.479085623828701 528 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_190 3970-0790 3.722 µM 0.0523597597855708 0.471853416565556 no 1563 0.479121018574727 521 2832352 SGTC_2520 obtusaquinone 4.71 µM 0.0520397012348575 0.471983094101037 no 1564 0.479248529622066 536 5967872 SGTC_3039 9090270 49.47 µM 0.0502964225782389 0.472689466903322 no 1565 0.479943087266298 525 17173750 SGTC_2262 9014885 67.46 µM 0.0496878747810149 0.472936069515795 no 1566 0.480185559523985 538 6457424 SGTC_2355 9061122 103.12 µM 0.0492309234940218 0.473121247302146 no 1567 0.480367633876551 520 5302957 SGTC_798 1287-0182 476 µM 0.0490707951003432 0.473186140106519 no 1568 0.480431438746324 518 1649755 SGTC_2238 6671620 73.2395 µM 0.0449259094083256 0.474866117690627 no 1569 0.48208318248446 517 729941 SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM 0.0438701369815977 0.475294108984046 no 1570 0.482503959805145 529 6728940 SGTC_2910 7948405 25.97 µM 0.0435476675989417 0.475424838021308 no 1571 0.482632483646457 532 2971328 SGTC_2718 lomofungin 53.02 µM 0.0433353012631609 0.47551093274634 no 1572 0.48271712565227 524 5351222 A RNA synthesis inhibitor. SGTC_31 0508-1974 57.237 µM 0.0432619818870642 0.475540657174807 no 1573 0.482746348445476 534 6810525 SGTC_3226 9131256 49.47 µM 0.0431808697942932 0.475573541009279 no 1574 0.482778677278007 512 17178073 SGTC_1665 st014639 11.4 µM 0.0424432091311322 0.475872605273436 no 1575 0.483072691729728 528 981133 YIL048W NEO1 SGTC_1044 1222-0021 1.78 µM 0.0416102240854865 0.476210332523465 no 1576 0.483404711330313 510 4306703 SGTC_446 go6976 132 µM 0.0409093687119524 0.476494502083785 no 1577 0.48368407427466 527 3501 A protein kinase C inhibitor. SGTC_3092 9117248 49.47 µM 0.0408192731774393 0.476531033184599 no 1578 0.483719987194757 540 17141857 SGTC_2239 6685329 187.64 µM 0.0385365557900309 0.477456673215876 no 1579 0.484629942906971 502 805680 SGTC_1276 0871-0068 94.2 µM 0.0381631132649374 0.477608115563585 no 1580 0.484778815404284 529 3414906 SGTC_1926 methyl fluorone black 53.6 µM 0.0381541236464678 0.477611761168334 no 1581 0.484782399133128 529 72721 Reacts with homocysteine. SGTC_2057 5236571 38.335 µM 0.0381223056922748 0.47762466447681 no 1582 0.484795083432171 525 54684039 YBR257W POP4 SGTC_1945 st075991 56.6 µM 0.0364795392963773 0.478290896051572 no 1583 0.485449996562631 518 1084980 SGTC_2121 5257820 149.641 µM 0.0358139059352219 0.478560864142694 no 1584 0.485715372423969 532 791256 SGTC_2824 7998404 51.95 µM 0.0358122447934406 0.478561537882213 no 1585 0.485716034698814 527 837851 SGTC_1190 1486-1332 13 µM 0.0357565957469448 0.478584108514682 no 1586 0.485738221246563 537 4150046 SGTC_3284 9108171 64.8615 µM 0.0349223987832371 0.478922457688421 no 1587 0.486070809929386 529 8687505 SGTC_256 clotrimazole 625 nM 0.0340953539924164 0.479257920946314 no 1588 0.48640055665486 525 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C SGTC_2623 humulene 100 µM 0.0339457203596236 0.479318616437586 no 1589 0.486460217301978 531 6187145 An anti-inflammatory. SGTC_822 1487-0950 154 µM 0.0332102362155619 0.479616955853866 no 1590 0.486753467653352 530 1958375 SGTC_3303 9125618 40.5795 µM 0.0322258409163696 0.48001628062932 no 1591 0.487145974403397 525 22695467 SGTC_1575 cyproterone acetate 48 µM 0.0315291837227664 0.480298895175853 no 1592 0.487423759232285 527 9880 An androgen receptor antagonist and liver toxin. SGTC_2380 9035439 200 µM 0.0311372204584033 0.480457908188906 no 1593 0.487580053208636 528 6462575 SGTC_3010 9080089 71.4286 µM 0.0304768653436757 0.480725810355986 no 1594 0.487843371795148 523 17027233 SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM 0.0303369190135321 0.480782586877028 no 1595 0.487899176499288 533 551469 SGTC_929 2805-0021 398 µM 0.030321243975684 0.480788946297214 no 1596 0.487905427059173 524 3098024 SGTC_3095 9117207 49.47 µM 0.0296772916732728 0.481050204308994 no 1597 0.488162211281471 535 17015229 SGTC_970 1315-0089 19.5 µM 0.0276371897233935 0.481877947666476 no 1598 0.488975759937678 533 6811083 YLR033W RSC58 SGTC_2137 5261020 140 µM 0.027132866222514 0.482082582185272 no 1599 0.489176880474764 530 763655 SGTC_114 0364-0001 490.298 µM 0.0268933953385712 0.482179751649536 no 1600 0.489272380685016 530 4003655 SGTC_1101 ebselen 5.29 µM 0.0260255137774434 0.482531918472717 no 1601 0.489618494144574 535 3194 A potent scavenger of hydrogen peroxide and hydroperoxides. SGTC_2647 atorvastatin 60.16 µM 0.0260196912900907 0.4825342811535 no 1602 0.489620816194605 536 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7 SGTC_1328 1441-0025 69.2 µM 0.0259716084613075 0.482553792490352 no 1603 0.489639991987622 521 4562601 SGTC_491 tetrandrine 80.3 µM 0.0257433440932187 0.482646419535386 no 1604 0.48973102585684 522 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM 0.0255050975099917 0.482743098247024 no 1605 0.489826041293105 535 2333 A French combination drug. SGTC_636 0kpi-0074 126 µM 0.0250551424822527 0.482925689452071 no 1606 0.490005490025824 537 616434 SGTC_1294 1000-1494 117 µM 0.024834670102863 0.483015158186109 no 1607 0.490093418418541 531 712797 YDL207W GLE1 SGTC_558 k064-0027 21.3 µM 0.0242401948514175 0.483256403303624 no 1608 0.490330508342546 528 5088526 SGTC_2525 harmine 47.85 µM 0.0236726569962648 0.483486722626764 no 1609 0.490556858224069 536 5280953 A monoamine oxidase inhibitor SGTC_599 1935-0052 86.5 µM 0.0236633439928323 0.483490502094207 no 1610 0.49056057253442 536 9557311 SGTC_2298 7976326 193.81 µM 0.0229969226821421 0.483760957628542 no 1611 0.490826363822603 536 2235818 SGTC_788 1182-0090 188 µM 0.0228201542550803 0.483832697288705 no 1612 0.490896865719741 536 5715185 SGTC_2041 5107442 45.335 µM 0.0221754280418752 0.484094357253753 no 1613 0.491154009176126 532 793005 SGTC_3109 9122853 49.47 µM 0.0218741307660696 0.484216640095076 no 1614 0.491274180247478 539 1234709 SGTC_3313 9133968 57.047 µM 0.0213875409735679 0.484414127859147 no 1615 0.491468256078326 542 1494643 SGTC_3030 9087619 49.47 µM 0.0211790782698593 0.484498735889348 no 1616 0.491551401830787 539 25236973 SGTC_862 0452-0056 10.2 µM 0.0200109792683626 0.484972840959587 no 1617 0.492017307065152 540 1575396 YLR359W | YHR072W ADE13 | ERG7 SGTC_1090 efavirenz 20.7 µM 0.0194536781598491 0.485199044451606 no 1618 0.492239594757663 527 64139 A non-nucleoside reverse transcriptase inhibitor. SGTC_907 3448-6986 75.5 µM 0.0194113652760584 0.485216219064849 no 1619 0.4922564719691 530 590582 SGTC_1214 0358-0031 63.7 µM 0.0193172350721543 0.485254426198513 no 1620 0.492294017447298 529 4301366 SGTC_2911 7942208 15.64 µM 0.0181220596126062 0.485739555556554 no 1621 0.492770739907142 540 1243384 SGTC_2439 5492030 7.2 µM 0.0180351308102683 0.485774841345083 no 1622 0.492805413814971 541 5722370 SGTC_2175 5807670 165.306 µM 0.0178695833704751 0.485842040001357 no 1623 0.492871447046354 535 241186 SGTC_1302 1159-0335 255 µM 0.0175487106511972 0.485972289099976 no 1624 0.492999436668917 542 649284 SGTC_1925 st057770 10.1 µM 0.0174056515985283 0.48603036031194 no 1625 0.493056500257817 524 5989122 SGTC_349 k015-0014 24 µM 0.0172987779831747 0.486073743152246 no 1626 0.493099130243207 536 2196908 SGTC_552 k242-0005 476 µM 0.0171254993738978 0.486144081894113 no 1627 0.493168248167533 543 4088318 SGTC_536 3852-0578 10.6 µM 0.0163971868282027 0.486439729468429 no 1628 0.49345876201721 535 2869208 SGTC_2059 5238311 157 µM 0.0162386858191277 0.486504071573255 no 1629 0.493521986353058 537 703021 SGTC_2736 butenafine 14.65 µM 0.0161831982723429 0.486526596342942 no 1630 0.49354411977304 544 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_1467 k284-1082 293 µM 0.0160399638999845 0.486584741502547 no 1631 0.493601254604034 533 3334705 SGTC_1682 st012968 530 nM 0.0149606415644169 0.487022895206063 no 1632 0.494031790173766 533 24207270 SGTC_1377 2944-0135 198 µM 0.0139805203596935 0.487420791538632 no 1633 0.494422761010258 539 1894137 SGTC_1678 st019265 80.2 µM 0.0138432869669563 0.487476504701264 no 1634 0.494477503915104 543 5367020 SGTC_955 1216-0110 33 µM 0.0134948901677814 0.487617945770834 no 1635 0.494616481143813 539 3619719 SGTC_1698 5-fluorocytosine 1.055 µM 0.012788718067083 0.487904640124727 no 1636 0.494898178719545 544 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_1268 0828-0275 2.46 µM 0.0126434522504449 0.487963616456722 no 1637 0.494956126710397 538 745337 SGTC_68 0986-0284 82.829 µM 0.0117091193650414 0.488342951619326 no 1638 0.495328843957884 543 423278 YIL048W NEO1 SGTC_645 0845-0943 5.41 µM 0.0116447566785941 0.488369082987411 no 1639 0.495354519204302 540 1885106 SGTC_3191 9110352 49.47 µM 0.0116107891529349 0.488382873884916 no 1640 0.495368069370391 542 17122424 SGTC_300 r073-0011 5.04 µM 0.0105392698559111 0.488817920353115 no 1641 0.495795517486391 545 2735780 SGTC_2704 st078022 71.1 µM 0.0101733409594343 0.48896649384873 no 1642 0.495941494165569 542 54697681 SGTC_477 mead ethanolamide 10 µM 0.00971502970587261 0.489152578345138 no 1643 0.496124324860601 543 16061185 SGTC_1718 roemerine 11.9335 µM 0.0084916473787894 0.489649310057003 no 1644 0.496612363543047 541 235224 An aporphine alkaloid with mutagenic activity. SGTC_55 0767-0285 6.563 µM 0.00831564541794413 0.489720773729132 no 1645 0.496682575687292 543 3116166 SGTC_1647 st011722 22.4 µM 0.00691270310411554 0.490290434727055 no 1646 0.497242252423298 544 2854783 SGTC_742 0kpi-0133 140 µM 0.00688825181439699 0.490300363287239 no 1647 0.497252006844338 544 2728852 SGTC_170 4197-0004 226 µM 0.00610100199896411 0.490620032922662 no 1648 0.497566067449207 544 218692 SGTC_2097 5376186 200 µM 0.00522461976106616 0.490975902631196 no 1649 0.497915687760752 544 742755 SGTC_2493 resveratrol 26.09 µM 0.00469488265714641 0.491191014769677 no 1650 0.498127019687225 546 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase. SGTC_3065 9113888 49.47 µM 0.00368824315039027 0.491599791289021 no 1651 0.498528607202836 544 16648368 SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM 0.00214850088576702 0.49222506728186 no 1652 0.499142872816612 546 91467 include heat shock SGTC_2158 5657123 3.6195 µM 0.00202199917096228 0.492276439402365 no 1653 0.499193339589436 546 2858827 SGTC_807 1315-0151 48 µM 0.00191488352372739 0.49231993897564 no 1654 0.4992360724672 547 4011080 SGTC_1725 st036284 20.55 µM 0.00179060017071763 0.492370410454061 no 1655 0.499285654266335 545 707914 SGTC_2660 2',4'-dihydroxychalcone 17.14 µM 0.00178913735592792 0.492371004503979 no 1656 0.499286237844068 545 5357218 A potent inhibitor of glutathione S-transferases. SGTC_625 k213-0058 121 µM 0.000206352421596834 0.493013784001667 no 1657 0.499917677294946 548 3655420 SGTC_113 0099-0221 2.5 µM 0.000160386893777162 0.493032451187613 no 1658 0.499936014887124 547 89219 SGTC_3286 9117135 37.221 µM -4.50579393043664e-05 0.493115885135372 no 1659 0.49998202448295 547 3438150 SGTC_147 4466-0538 29.23 µM -0.000363132452952247 0.49324506012477 no 1660 0.499855131114315 548 6742687 YHR072W ERG7 SGTC_426 0988-0037 14.6 µM -0.000412543944445745 0.493265126961135 no 1661 0.499835418782705 548 5383008 SGTC_494 Boc-Gly-Val-Val-CHO 140 µM -0.00224630615433699 0.494009860206171 no 1662 0.499103854253951 549 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA. SGTC_1741 st038134 10.228 µM -0.00589414326154503 0.495491390754415 no 1663 0.497648590661257 553 1272587 SGTC_1219 1469-0211 33.1 µM -0.00594225816604023 0.495510932575599 no 1664 0.49762939592769 556 6822282 SGTC_176 1486-1328 72.834 µM -0.00611166068450132 0.495579735327438 no 1665 0.497561815328168 549 22310231 SGTC_2083 5306046 65.942 µM -0.0079286173566286 0.496317699261636 no 1666 0.496836972450904 551 539837 SGTC_905 2-aminofluorene 215 µM -0.00796530866015888 0.496332601713849 no 1667 0.496822335200812 552 1539 An established DNA mutagen. YPR165W RHO1 SGTC_77 0828-0286 12.516 µM -0.0100649284643457 0.497185386155462 no 1668 0.495984742279269 562 745345 SGTC_161 4065-0411 162.148 µM -0.0102158334446751 0.497246678469826 no 1669 0.495924542997495 557 1906281 YLR208W SEC13 SGTC_958 1222-0007 33 µM -0.0113739639777237 0.497717072560527 no 1670 0.49546254270665 555 7312461 SGTC_2804 7954240 19.48 µM -0.0120843599712504 0.498005613390012 no 1671 0.495179155208901 558 828705 SGTC_514 4466-0038 2.65 nM -0.013237451427374 0.498473965546711 no 1672 0.494719175167906 559 5722064 SGTC_1837 st055472 66.5 µM -0.013665664821047 0.498647893922177 no 1673 0.494548358196328 560 676091 SGTC_2504 purpurogallin 52.29 µM -0.0142340421055193 0.498878753364678 no 1674 0.494321630530879 557 5281571 An antioxidant. SGTC_982 1491-0518 27.5 µM -0.0143327269840309 0.498918836527105 no 1675 0.494282264976208 552 3091256 SGTC_228 caffeine 993.056 µM -0.0148038823323126 0.499110207391543 no 1676 0.494094321134116 559 2519 Caffeine is a phosphodiesterase inhibitor. SGTC_251 melphalan 456.522 µM -0.0163249679787246 0.499728033400222 no 1677 0.493487569313806 563 460612 A DNA alkylator. SGTC_1072 oxiconazole 14.9 nM -0.0168985016767706 0.499960988339626 no 1678 0.49325879404297 557 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_3252 9135871 49.47 µM -0.0170905946190105 0.499960988339626 no 1679 0.493182171112374 560 17682838 SGTC_1360 1598-0022 39.8 µM -0.0182052191606001 0.499508256014641 no 1680 0.492737569519639 566 761525 SGTC_2311 7694451 200 µM -0.0191530686719876 0.499123263968298 no 1681 0.492359498250495 554 2163142 SGTC_2883 9059145 45.46 µM -0.019819265610178 0.498852672406626 no 1682 0.49209377458354 551 16476510 SGTC_2576 guaiol 23.12 µM -0.0202557047013183 0.49867540267901 no 1683 0.491919695528595 557 227829 SGTC_2344 7990960 76.95 µM -0.0223403651274761 0.497828674341893 no 1684 0.491088225096342 567 140813 SGTC_3209 9113616 49.47 µM -0.0227376593455307 0.497667305996988 no 1685 0.490929767889846 567 16649353 SGTC_1526 st051518 75 µM -0.0227749203719957 0.497652171765777 no 1686 0.490914906739391 571 673993 SGTC_2463 5473429 200 µM -0.0227933722440448 0.497644677209727 no 1687 0.490907547417901 578 5399405 SGTC_504 lovastatin 124 µM -0.0244295758896032 0.496980107606998 no 1688 0.490254978606582 573 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1 SGTC_1604 st002052 72.4 µM -0.0246319256135883 0.496897920658847 no 1689 0.490174277031447 562 6254834 YHR062C RPP1 SGTC_424 splitomicin 100 mM -0.0246651658635472 0.496884419715444 no 1690 0.490161020118063 573 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_358 0075-0058 9.45 µM -0.0257777154222712 0.49643254594757 no 1691 0.489717318229427 575 1069125 SGTC_448 monastrol 171 µM -0.0269813879642325 0.495943666789095 no 1692 0.489237289440106 554 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity SGTC_1201 1889-3372 45.9 µM -0.027427596719309 0.495762437810899 no 1693 0.489059343762891 560 5392199 SGTC_1558 st069300 45.6 µM -0.028084039014662 0.495495823471794 no 1694 0.488797562037165 563 24208000 SGTC_2329 6138490 200 µM -0.0287641279062992 0.495219607180144 no 1695 0.488526355409001 589 720019 SGTC_2598 perillyl alcohol 100 µM -0.0288459874503565 0.495186360296303 no 1696 0.488493711721387 564 10819 An apoptosis inducer. SGTC_3338 9144300 39.5675 µM -0.0289250230734618 0.495154260366916 no 1697 0.48846219422109 572 4901274 SGTC_3278 9139605 49.47 µM -0.0301011673907546 0.494676578961418 no 1698 0.487993184855497 588 7958859 SGTC_302 1094-0063 18.9 µM -0.0301208627291061 0.494668579923725 no 1699 0.487985331113498 557 5440289 SGTC_2013 4024628 200 µM -0.0309233874664848 0.494342645487499 no 1700 0.487665319169577 573 5230760 SGTC_326 k292-0812 17.5 µM -0.0333564485723708 0.493354515007881 no 1701 0.486695169662 571 3579357 SGTC_1266 0828-0227 32.9 µM -0.03371627190116 0.493208384550124 no 1702 0.486551701624484 565 3913820 SGTC_1654 st012436 41.8 µM -0.0350887526100296 0.492651005007641 no 1703 0.486004485003862 571 4323132 SGTC_143 4032-1194 15.74 µM -0.0354014976876329 0.492523997752833 no 1704 0.48587979523997 564 1806963 SGTC_314 1671-0008 2.74 µM -0.0360120956072776 0.492276033246576 no 1705 0.485636357155529 567 3913060 SGTC_875 0709-0210 25.7 µM -0.0361550500960076 0.492217979694565 no 1706 0.485579363681372 562 6251364 SGTC_1445 4239-0156 97.7 µM -0.0368627277127128 0.491930595582053 no 1707 0.48529722925607 592 4008346 SGTC_1792 st045773 43.6 µM -0.0369551554446272 0.49189306147826 no 1708 0.485260381033104 570 2919270 SGTC_914 3820-6779 408 µM -0.0381021185737203 0.491427295733133 no 1709 0.48480313108039 567 2893481 SGTC_1414 3917-0015 5.4 µM -0.0388593288791903 0.491119809544971 no 1710 0.484501271456093 564 6618702 SGTC_1979 st071809 45.3 µM -0.0403494277752308 0.490514729255843 no 1711 0.483907274086563 592 4976333 SGTC_435 c-PAF 6.7 µM -0.0411867994035545 0.490174709592235 no 1712 0.483573488646871 567 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase SGTC_3185 9108267 49.47 µM -0.0415115532070888 0.490042843312503 no 1713 0.483444041333358 577 4910486 SGTC_3324 9138759 60.749 µM -0.0425312498004258 0.489628802657996 no 1714 0.483037600271592 577 45595710 SGTC_1274 0865-0114 173 µM -0.0432709924334483 0.489328442315872 no 1715 0.482742757120587 561 870624 SGTC_2517 totarol 10 µM -0.0439944217609234 0.489034711575401 no 1716 0.482454425177 565 460178 An antibacterial membrane disruptor. YGL001C ERG26 SGTC_707 0865-0008 204 µM -0.0444366197685021 0.488855170835251 no 1717 0.482278186055952 567 723043 SGTC_1844 rapamycin 4 nM -0.0457503716935154 0.488321776211629 no 1718 0.481754607503853 580 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2 SGTC_2974 9094440 9.66 µM -0.0499609264462065 0.486612400101704 no 1719 0.480076762796543 576 25236134 SGTC_1243 0416-0003 5.65 µM -0.050792830087781 0.486274696885489 no 1720 0.479745302132593 576 2141977 SGTC_3063 1327-0034 4 µM -0.0509536035492203 0.486209433585234 no 1721 0.479681245746643 570 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_2488 5268135 45.7 µM -0.0510397285264669 0.486174472741626 no 1722 0.479646931500697 582 1270356 YLR208W SEC13 SGTC_2755 lomerizine 42.69 µM -0.0517005428579288 0.485906230925716 no 1723 0.479383652340924 575 3949 A calcium channel blocker. SGTC_2858 9025781 8.96 µM -0.0517346964131304 0.485892367276891 no 1724 0.479370045253424 588 4894980 YPL153C RAD53 SGTC_2308 7584454 197.62 µM -0.0525477280685697 0.485562345641741 no 1725 0.479046133169943 582 893577 SGTC_1755 st041960 45.185 µM -0.0533259098607432 0.485246479342867 no 1726 0.478736118241946 568 2257073 SGTC_879 0831-1030 162 µM -0.0536066429544787 0.485132531208729 no 1727 0.47862428190607 574 1549252 SGTC_1164 k060-0068 93.7 µM -0.0548910247209737 0.484611222809905 no 1728 0.4781126411675 568 5963676 SGTC_2434 5670830 169.91 µM -0.0565508050306925 0.483937585703998 no 1729 0.477451511842504 590 1549830 SGTC_639 0833-0042 114 µM -0.056579487552353 0.48392594503618 no 1730 0.477440087463345 571 5978911 YPR085C | YHR062C ASA1 | RPP1 SGTC_3210 9128157 49.47 µM -0.0569355589843953 0.483781436247877 no 1731 0.47729826413508 614 17590849 SGTC_2531 methyl deoxycholate 70.07 µM -0.0572478764253624 0.483654686425631 no 1732 0.477173870397232 580 16667744 Haematoxylin. SGTC_2056 5235370 200 µM -0.0573662718434759 0.483606637672664 no 1733 0.477126714954389 583 5511916 SGTC_1689 st020265 53.493 µM -0.0576905748998234 0.483475026052026 no 1734 0.476997550666916 568 5758320 YPR016C TIF6 SGTC_2180 6301957 200 µM -0.0580974146383289 0.483309921191075 no 1735 0.476835516868184 592 845462 SGTC_194 1486-1323 56.904 µM -0.0581966784981316 0.483269638082126 no 1736 0.476795983207349 566 5178754 SGTC_799 1310-0557 151 µM -0.0590844817493777 0.482909358756675 no 1737 0.476442409408486 614 5354492 SGTC_376 3970-0862 59.1 µM -0.0591840620501549 0.482868948952366 no 1738 0.476402752015097 587 3135186 SGTC_1131 3454-3128 32.3 µM -0.0593269169401122 0.482810978575798 no 1739 0.476345861125321 568 710982 SGTC_188 3229-0966 278.469 µM -0.0594093584620785 0.482777524050988 no 1740 0.476313029626122 568 5722370 SGTC_2201 6605497 169.863 µM -0.0598072951210779 0.482616044245917 no 1741 0.476154557656751 576 670741 SGTC_1553 gossypol 38.6 µM -0.0600067602599277 0.482535103813061 no 1742 0.476075125243077 580 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_1982 st072467 71.9 µM -0.0606780103748431 0.482262724304986 no 1743 0.475807822292007 595 3163533 SGTC_3302 9125395 16.351 µM -0.0613267747495959 0.481999476914627 no 1744 0.475549483881202 587 17599668 SGTC_631 k072-0230 41.5 µM -0.0621704499002946 0.481657152854813 no 1745 0.475213547258366 594 5773147 SGTC_3246 9135460 32.98 µM -0.0622374994332627 0.481629947855733 no 1746 0.47518685006497 568 41446951 SGTC_3045 9092950 49.47 µM -0.0623718248319875 0.48157544628171 no 1747 0.475133365894259 593 44120432 SGTC_2539 epi(13)torulosol 80 µM -0.0623833757256236 0.481570759604934 no 1748 0.475128766710752 589 6708597 SGTC_650 1328-0195 38 µM -0.0626673576350624 0.481455537164994 no 1749 0.47501569555814 577 2780821 SGTC_2941 9056145 11.23 µM -0.0628963240442977 0.481362637768073 no 1750 0.474924531019289 575 2119517 SGTC_2958 9077254 16.72 µM -0.0629853017537536 0.481326536782279 no 1751 0.474889104290835 577 16457351 SGTC_90 0870-0863 4.608 µM -0.0631732010037217 0.481250300796948 no 1752 0.474814292321942 581 1738164 SGTC_2199 6590217 200 µM -0.0632851042955632 0.48120489882469 no 1753 0.474769738518009 583 703109 SGTC_1519 esterone 74 µM -0.063403915456069 0.481156694423692 no 1754 0.47472243472187 583 698 A steroid. SGTC_6 0844-0013 19.835 µM -0.0644052180241111 0.480750454120778 no 1755 0.474323787636455 583 1584900 SGTC_2223 6903751 107.57 µM -0.0649009861285708 0.480549322505944 no 1756 0.474126417717161 574 5598863 SGTC_2266 7929956 200 µM -0.0655400549298721 0.480290061546182 no 1757 0.473872007826129 575 2967153 SGTC_1354 1498-1681 81 µM -0.0656077681333773 0.480262591766513 no 1758 0.473845052182455 587 5754243 SGTC_2701 st077767 14.721 µM -0.066006545820757 0.480100818203944 no 1759 0.47368630700543 595 5721188 SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM -0.0674911663039428 0.47949857595949 no 1760 0.473095347130152 576 16623 A steroid. SGTC_637 1181-0519 7.26 µM -0.0678091169869508 0.479369604029459 no 1761 0.472968793081671 581 6252091 YGR060W ERG25 SGTC_378 3970-0959 8.33 µM -0.0678592512220814 0.479349268025042 no 1762 0.472948838378986 593 6615653 SGTC_1461 k072-0203 53.8 µM -0.0680358973107706 0.479277615308371 no 1763 0.472878529277202 578 5418714 SGTC_1572 epiandrosterone 68.9 µM -0.0690505244314885 0.47886606650743 no 1764 0.472474701378676 569 441302 A steroid. SGTC_2572 astragaloside iv 100 µM -0.0695558039426795 0.478661125526359 no 1765 0.472273607520415 570 45006101 An anti-inflammatory agent. SGTC_456 gingerol 170 µM -0.0699210111587725 0.478513001269968 no 1766 0.472128264784924 599 442793 A herb. SGTC_3240 9133527 49.47 µM -0.0711340119843677 0.478021042137005 no 1767 0.471645549537276 618 17617455 SGTC_2806 7952793 58.44 µM -0.0715398090461989 0.477856469662249 no 1768 0.471484071333971 582 2972490 SGTC_2761 levamisole 97.89 µM -0.0719101311780659 0.477706287468908 no 1769 0.471336713705496 580 26879 An alkaline phosphatase inhibitor. SGTC_1230 0170-0365 3.77 µM -0.0723014597808353 0.477547589652541 no 1770 0.471181001500931 579 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1 SGTC_2688 kanamycin b 96.69 µM -0.074015705614312 0.476852443633632 no 1771 0.47049894413298 588 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis. SGTC_283 0987-0079 11.7 µM -0.0740750307798486 0.476828387858673 no 1772 0.470475341607905 577 411556 SGTC_193 1273-0060 1.558 µM -0.0751087888580393 0.476409222691192 no 1773 0.470064077540985 614 2847393 YHR072W ERG7 SGTC_2205 7238770 200 µM -0.0757935575169678 0.476131579064192 no 1774 0.469791670869731 601 279867 SGTC_3340 9146634 11.102 µM -0.0762039157353948 0.4759652023672 no 1775 0.469628433721995 577 4907387 SGTC_1686 st019653 115.5 µM -0.0762269069407127 0.475955880877169 no 1776 0.46961928815905 584 97252 SGTC_2518 prenyletin 46.28 µM -0.0787238829199687 0.474943593319763 no 1777 0.468626124304004 573 3873459 A coumarin with calcium channel inhibitory activity. SGTC_305 1682-2595 20.8 µM -0.0788483619638816 0.474893133020731 no 1778 0.468576618237417 595 226033 SGTC_1803 st050068 52.4 µM -0.0788841317556663 0.474878633028886 no 1779 0.468562392465312 591 3984059 YIL048W | YNL267W NEO1 | PIK1 SGTC_739 1486-1183 203 µM -0.0794240873472259 0.474659755414457 no 1780 0.4683476551125 588 4346692 SGTC_102 gallobenzophenone 83.616 µM -0.0800674736562326 0.474398960882819 no 1781 0.468091795964395 581 70837 SGTC_1436 4092-1007 8.32 µM -0.0801903403634885 0.474349158509821 no 1782 0.468042936347143 576 2881121 SGTC_1582 3',3',6'-trihydroxyflavone 74 µM -0.0807113844313669 0.47413796474409 no 1783 0.467835741445034 572 688803 SGTC_1508 1080-0625 72.9 µM -0.0810822093094522 0.4739876634501 no 1784 0.467688287006072 576 767111 SGTC_3175 9106517 49.47 µM -0.0816289517268028 0.473766066705009 no 1785 0.467470888983235 590 41468073 SGTC_2019 4016004 108 µM -0.0819347975123095 0.473642109801141 no 1786 0.467349281521403 591 45595336 SGTC_662 k832-1615 104 µM -0.0820393283570169 0.473599744852218 no 1787 0.467307719669723 580 5878478 SGTC_613 3914-0030 117 µM -0.0825731771662182 0.47338338775878 no 1788 0.467095464970409 580 1145395 SGTC_1562 morin hydrate 59.1 µM -0.0827551410700353 0.473309643611481 no 1789 0.467023119480026 600 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase. SGTC_1404 3909-7820 48.3 µM -0.0827572852304271 0.473308774657336 no 1790 0.46702226700791 589 23741373 SGTC_3015 9080845 49.47 µM -0.0843150281067323 0.472677509104049 no 1791 0.466402982123562 596 5296973 SGTC_3013 9080133 71.4286 µM -0.0849660638315263 0.472413701191141 no 1792 0.466144185127404 585 17050193 SGTC_2584 androsterone 48.74 µM -0.0850236877689552 0.47239035182385 no 1793 0.466121279389013 592 2754130 A steroid. SGTC_2738 aclarubicin 5.55 µM -0.0851279051248146 0.472348122924898 no 1794 0.466079852871345 581 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31 SGTC_461 N-acetylfarnesylcysteine 136 µM -0.0860382141350029 0.471979278750259 no 1795 0.465718019677199 587 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ). SGTC_1248 0469-0687 58.6 µM -0.0865488569297139 0.471772384102916 no 1796 0.465515059764984 601 4017482 SGTC_390 dec-rvkr-cmk 16.7 µM -0.0902968660993721 0.470254058258883 no 1797 0.464025655235023 596 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1 SGTC_2997 9067075 71.4286 µM -0.0923274354928623 0.469431649789904 no 1798 0.463218945544761 595 27209819 SGTC_1337 1486-1011 40.3 µM -0.0931340286349089 0.469105004489524 no 1799 0.462898541984938 584 X1337 SGTC_3044 9093193 49.47 µM -0.0931743273293641 0.469088685306998 no 1800 0.462882534735827 613 25236277 SGTC_2628 lathosterol 100 µM -0.0934967166420171 0.468958133817036 no 1801 0.462754479005363 609 6710616 SGTC_3249 9135183 49.47 µM -0.0935044978714545 0.468954982850871 no 1802 0.462751388283624 594 4902779 SGTC_523 1934-0222 13.7 µM -0.0940186813737299 0.468746771382123 no 1803 0.462547158439173 611 1361595 SGTC_1625 st003711 30.1 µM -0.0944422603584731 0.468575255373089 no 1804 0.462378923446159 604 24207034 YER133W GLC7 SGTC_2060 5238662 140 µM -0.0948628415820297 0.468404958990933 no 1805 0.462211885747567 606 790130 SGTC_2125 5246583 200 µM -0.0949138045674229 0.468384324101292 no 1806 0.462191645781611 596 835267 SGTC_3111 9122088 49.47 µM -0.0969514102159895 0.467559368675425 no 1807 0.461382490809629 593 16876704 SGTC_2514 salinomycin 42.74 µM -0.0970779874346533 0.467508126535799 no 1808 0.461332230882291 613 23682228 A polyether potassium ionophore. SGTC_2182 6325192 200 µM -0.0987357627707465 0.466837060882173 no 1809 0.46067403650176 577 736248 SGTC_3104 9120930 49.47 µM -0.0993274976111893 0.466597549990168 no 1810 0.460439123215749 579 17014836 SGTC_1736 st036774 51 µM -0.100599776554764 0.4660826227971 no 1811 0.459934087045597 590 1272247 SGTC_215 1287-0124 461.5 µM -0.100781729898861 0.466008985764132 no 1812 0.459861865208384 604 5560863 SGTC_3025 9087895 49.47 µM -0.101013117420632 0.465915344260846 no 1813 0.459770023621803 597 17173641 SGTC_665 3914-0008 307 µM -0.10377996417815 0.464795761308196 no 1814 0.458671983434941 616 1069549 SGTC_2595 hexamethylquercetagetin 100 µM -0.104590991424662 0.464467637875229 no 1815 0.458350181649596 623 386331 SGTC_2913 7966556 36.57 µM -0.104869305096499 0.464355043963461 no 1816 0.458239757809304 606 2976516 SGTC_2789 5281112 71.43 µM -0.106693721322804 0.463617033604709 no 1817 0.45751598191643 594 765948 SGTC_1368 1852-0141 284 µM -0.107571173812408 0.463262132148519 no 1818 0.457167932119071 599 2838987 SGTC_2634 4'-methoxyflavone 100 µM -0.108515693807907 0.462880136714824 no 1819 0.456793316083814 610 77793 From seeds of Psoralea corylifolia (Fabaceae) SGTC_1555 citronellol 128 µM -0.108835428179474 0.462750833192566 no 1820 0.456666511545049 595 8842 A terpine precursor. SGTC_507 nimesulide 162 µM -0.110093105914212 0.462242255060785 no 1821 0.456167767803159 596 4495 A COX2 inhibitor. SGTC_1600 coumarin 106 71.1 µM -0.110143766862571 0.462221770138246 no 1822 0.45614767917692 635 100336 A hepatotoxic, DNA x-linker. SGTC_1995 st072814 61.1 µM -0.111116249736475 0.461828562949191 no 1823 0.455762081555786 596 5769371 SGTC_368 fentichlor 4.58 µM -0.112175706013341 0.461400231991732 no 1824 0.45534204568361 604 7329 A pesticide. SGTC_1127 asiatic acid 681.4 nM -0.112499668583451 0.461269265046312 no 1825 0.455213616253783 608 470603 A kinase inhibitor which arrests cells at G2/M. SGTC_1085 doxorubicin 7.67 µM -0.11295045083123 0.461087036250574 no 1826 0.455034919118545 594 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_2012 4023501 200 µM -0.113510333104069 0.460860715132591 no 1827 0.454812985698402 607 3477460 SGTC_1943 st076331 65.2 µM -0.11379724497411 0.460744741703182 no 1828 0.454699261299591 600 24208415 SGTC_3247 9135149 49.47 µM -0.1158273283366 0.459924252128765 no 1829 0.453894695700575 595 8934436 YOR116C RPO31 SGTC_462 ag-879 158 µM -0.115930778110357 0.459882445843047 no 1830 0.453853701372968 610 6809654 Ag-879 is a 5-Lipoxygenase inhibitor. SGTC_414 piperonyl butoxide 100 µM -0.118215715384156 0.458959167299969 no 1831 0.452948369097665 613 5794 A potent inhibitor of cytochrome P450. SGTC_2399 5884133 200 µM -0.119567973169907 0.458412862099485 no 1832 0.452412695688169 615 722445 SGTC_726 3448-4391 34.2 µM -0.11984936293982 0.45829919191601 no 1833 0.452301238877154 612 1356692 SGTC_2689 tacrolimus 100 µM -0.120114558527756 0.458192066653967 no 1834 0.452196199925459 596 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). SGTC_837 0091-0265 12.5 µM -0.120729287298332 0.457943759807158 no 1835 0.451952730376622 608 759367 SGTC_1290 0986-0249 10.2 µM -0.121078536898809 0.457802695031074 no 1836 0.451814414581953 607 53329 SGTC_1068 loratadine 26.9 µM -0.121144655446408 0.457775989805653 no 1837 0.451788229842856 614 3957 A H1 histamine antagonist. SGTC_633 0437-0093 97.7 µM -0.121702615268497 0.457550637909391 no 1838 0.451567270976134 599 2831118 SGTC_1740 st038286 13.222 µM -0.122379246957405 0.457277374480123 no 1839 0.451299336744958 605 716786 SGTC_1341 1486-1360 280 µM -0.123864157542798 0.456677751762047 no 1840 0.450711416243533 603 3976547 SGTC_1629 st005085 44.9 µM -0.124185585130715 0.456547968815614 no 1841 0.450584167642118 611 24207091 SGTC_1685 st024049 53.0905 µM -0.125223891381644 0.45612876322233 no 1842 0.450173151764123 615 1941139 SGTC_362 0310-0100 9.03 µM -0.125789382888603 0.455900472284393 no 1843 0.449949323121122 612 790235 SGTC_2327 6189656 200 µM -0.12632517572974 0.455684184234196 no 1844 0.449737264270771 619 5349088 SGTC_2884 9058502 51.95 µM -0.126479623393376 0.455621839468771 no 1845 0.449676138841246 629 6471554 SGTC_2326 6164455 177.58 µM -0.126791882579094 0.455495795413368 no 1846 0.449552560323876 612 2888790 SGTC_1397 3532-0190 20.1 µM -0.12743307144629 0.455236992279576 no 1847 0.449298821187489 601 5322280 SGTC_1775 st081588 35.1725 µM -0.132521457474291 0.453183848928593 no 1848 0.447285926045252 607 1426443 YGL099W LSG1 SGTC_1 0258-0098 57.368 µM -0.133044060260533 0.452973050703923 no 1849 0.447079267578896 581 6790032 YDR047W HEM12 SGTC_3096 9117468 49.47 µM -0.133104818793558 0.45294854386539 no 1850 0.447055242106986 617 41316311 SGTC_2031 5180455 200 µM -0.134185679478914 0.452512610805107 no 1851 0.446627874808923 605 29949 SGTC_252 miconazole 1.30953 nM -0.134503516545605 0.452384431529243 no 1852 0.446502215278544 621 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_2654 protoveratrine a 100 µM -0.134513150116871 0.45238054652113 no 1853 0.446498406649757 612 5702278 A heart drug and vasodilator. SGTC_2998 9066762 71.4286 µM -0.134658132889392 0.452322078697987 no 1854 0.446441088361268 613 4945196 SGTC_892 0929-0076 29 µM -0.135844484958433 0.451843692378175 no 1855 0.445972111542348 592 5751038 SGTC_1826 st055655 41.6 µM -0.138624337088195 0.450723015845775 no 1856 0.444873505387182 603 676168 SGTC_3251 9135047 49.47 µM -0.139168125225439 0.450503837384724 no 1857 0.444658647871515 609 17682963 SGTC_818 4072-2707 53.5 µM -0.142265278842157 0.449255792890122 no 1858 0.44343523549844 611 882871 SGTC_803 4488-1585 147 µM -0.142631664383755 0.449108185298876 no 1859 0.443290544293695 641 747204 SGTC_593 1203-0218 61.7 µM -0.143182872012259 0.448886130776028 no 1860 0.443072878295362 615 3666956 SGTC_652 0437-0092 114 µM -0.143616105814409 0.448711613355684 no 1861 0.442901810953082 608 3091274 SGTC_3151 9099821 49.47 µM -0.144682653082184 0.448282023773321 no 1862 0.442480717934521 650 17174189 SGTC_2920 7982904 15.77 µM -0.14544996364254 0.447972999821525 no 1863 0.442177809383554 629 6456808 SGTC_1660 st012960 28.1 µM -0.145731301886799 0.447859702548571 no 1864 0.442066754912732 620 24207266 SGTC_1829 berberine 14.4 µM -0.14625167456302 0.44765015531954 no 1865 0.441861356835091 603 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_2639 lactacystin 53 µM -0.148577900302222 0.446713594275518 no 1866 0.440943356215823 615 3870 A proteasome inhibitor. SGTC_1166 k206-0078 225 µM -0.149106029878339 0.446501005385643 no 1867 0.440734983963857 611 5404595 SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM -0.149739539729943 0.446246017883556 no 1868 0.44048505582878 687 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W SGTC_1394 3474-0001 65.7 µM -0.15007205930808 0.4461121877537 no 1869 0.440353881875771 612 5017666 YIL048W NEO1 SGTC_1317 1273-0028 910 nM -0.150311181168399 0.44601595147085 no 1870 0.44025955595751 629 5917803 YLR359W | YHR072W ADE13 | ERG7 SGTC_1754 st042065 16.137 µM -0.150464621146779 0.445954200141669 no 1871 0.440199030583898 619 1126236 YIL048W NEO1 SGTC_2353 9059630 146.67 µM -0.150683144270315 0.445866258614259 no 1872 0.440112835162929 630 4779114 SGTC_838 0109-0203 71.4 µM -0.151133675343199 0.445684957192754 no 1873 0.43993513425698 610 759422 SGTC_587 k089-0003 57 µM -0.152171378026993 0.445267411123825 no 1874 0.43952588403059 605 9659696 SGTC_2929 9013348 24.6 µM -0.153850253290803 0.444592001722175 no 1875 0.438863904549839 626 2995952 SGTC_1896 st058441 89 µM -0.154059243609197 0.444507936398359 no 1876 0.438781511724652 610 688759 SGTC_2430 5571206 200 µM -0.154535792339372 0.444316256365495 no 1877 0.438593645980609 615 1731771 SGTC_2825 7998094 58.44 µM -0.154589791823322 0.444294537218769 no 1878 0.438572359096184 642 2987815 SGTC_549 1661-1316 519 µM -0.156733141878091 0.443432595586321 no 1879 0.437727583213974 643 2857282 SGTC_1257 0669-0121 16 µM -0.157135089832764 0.443270983124581 no 1880 0.437569191698167 610 4307855 SGTC_2280 7785178 200 µM -0.157436936764697 0.443149624794212 no 1881 0.437450252543256 608 2954328 SGTC_1036 k216-0215 33.5 µM -0.161495240657436 0.4415184957009 no 1882 0.43585167978159 614 622330 SGTC_3113 9123498 49.47 µM -0.162916920568106 0.440947321697469 no 1883 0.435291924066476 604 8897275 SGTC_512 prima-1 270 µM -0.163579536961316 0.440681150879309 no 1884 0.435031077416364 622 322968 A re-activator of the apoptotic function of mutant p53. SGTC_168 3970-0862 530.542 µM -0.163620625143744 0.440664646773188 no 1885 0.435014903505211 616 3135186 SGTC_1371 2421-0008 32.7 µM -0.164115376393634 0.440465925539785 no 1886 0.434820158661721 642 2827552 SGTC_2004 4023728 41.89 µM -0.164191006786366 0.440435549240796 no 1887 0.434790390287742 629 360084 YDR527W RBA50 SGTC_1138 3761-0006 1.03 µM -0.164191094660434 0.440435513947134 no 1888 0.434790355700432 618 12061087 SGTC_3124 9127567 49.47 µM -0.16606791269145 0.439681818811791 no 1889 0.434051752723654 648 17592030 SGTC_1212 0520-0165 585 µM -0.167876154708047 0.438955869216944 no 1890 0.433340354832558 707 5403258 SGTC_100 0086-0128 49.5915 µM -0.169319266188143 0.438376654673913 no 1891 0.432772761272062 670 93297 SGTC_432 NS 1619 61.3 µM -0.169914727870017 0.438137695544142 no 1892 0.432538599190884 616 4552 A K+/calcium channel activator. SGTC_2264 7948757 110.76 µM -0.170660174230342 0.43783857927426 no 1893 0.432245489849947 607 2971411 SGTC_1213 1315-0166 115 µM -0.171412784107925 0.437536624615448 no 1894 0.431949601641753 640 768401 SGTC_1322 1348-1070 12 µM -0.171562810336259 0.437476436925035 no 1895 0.431890623460399 623 6758089 SGTC_1688 st021091 57.6 µM -0.171853275457158 0.437359911915624 no 1896 0.431776440378618 650 3656366 SGTC_3180 9109287 49.47 µM -0.172412180257893 0.437135713069494 no 1897 0.431556748552926 614 18891271 SGTC_2252 omeprazole 400 µM -0.173176643985294 0.43682908910067 no 1898 0.431256290826444 646 4594 A proton pump inhibitor. SGTC_2319 6033012 152.6 µM -0.173989527156492 0.436503085879116 no 1899 0.430936846407952 616 847246 SGTC_2469 5655019 90.81 µM -0.175384657780666 0.435943675515648 no 1900 0.430388697529913 643 2788239 SGTC_973 1325-0077 65.9 µM -0.175945185884469 0.435718954636205 no 1901 0.430168502918298 644 2835149 SGTC_3115 9123671 49.47 µM -0.177682452570787 0.435022600576066 no 1902 0.429486183387192 609 3286988 SGTC_2334 9017922 200 µM -0.17821877136616 0.434807666830805 no 1903 0.429275584145963 619 3163164 SGTC_1499 4480-0877 67.3 µM -0.178327046131271 0.434764277248676 no 1904 0.429233069740565 603 2861909 SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM -0.179007378259366 0.434491661760207 no 1905 0.428965954129649 650 5024745 SGTC_1140 3229-1848 2.98 µM -0.181237513817185 0.433598244510242 no 1906 0.428090575187479 655 2849525 SGTC_2 0422-0095 29 µM -0.181806034921346 0.433370542668774 no 1907 0.427867474136657 614 6790840 SGTC_1768 st044301 37.178 µM -0.182126704871459 0.433242118948815 no 1908 0.427741645873785 637 3931349 SGTC_975 1335-0046 28.5 µM -0.183431272968751 0.432719730931849 no 1909 0.427229819924776 656 16486740 SGTC_673 1082-0474 110 µM -0.185020244952434 0.4320836179943 no 1910 0.42660657826842 645 3098046 SGTC_3311 9131146 2.8755 µM -0.187299285489358 0.431171557705817 no 1911 0.425712991585399 637 4900406 YPR165W RHO1 SGTC_3073 9114972 49.47 µM -0.189432160221975 0.430318324464751 no 1912 0.424877060271181 618 41905075 SGTC_1838 st055369 84.5 µM -0.189714678975839 0.430205330231292 no 1913 0.424766358774849 616 676036 SGTC_203 k066-0004 30.888 µM -0.190026528846106 0.430080611565312 no 1914 0.424644171131089 629 6795412 SGTC_2751 anetholtrithion 17.25 µM -0.190461019346694 0.429906856649811 no 1915 0.424473943049535 656 2194 A chloretic substance that stimulates the liver to produce bile. SGTC_2028 5153890 36.43 µM -0.190762442499817 0.429786324002506 no 1916 0.424355857406576 655 2830968 YPR165W RHO1 SGTC_387 norethindrone acetate 66.7 µM -0.19147551252017 0.429501208683199 no 1917 0.424076531887863 655 541197 SGTC_2551 apiole 73.87 µM -0.192728734645145 0.429000207069561 no 1918 0.423585709167372 623 10659 A possible DNA adduct former. SGTC_1683 st010134 710 nM -0.193370322566883 0.428743763162425 no 1919 0.423334477969762 674 3818134 SGTC_1207 2099-0101 141 µM -0.194578708221196 0.428260850889443 no 1920 0.422861386415894 631 5837381 SGTC_2668 2',4'-dihydroxychalcone 15.08 µM -0.195808929764194 0.427769322588841 no 1921 0.422379860216854 627 5357218 A potent inhibitor of glutathione S-transferases. SGTC_810 3825-7150 143 µM -0.19701935955222 0.427285811352333 no 1922 0.421906193984633 632 22330411 YGL099W LSG1 SGTC_2231 micatex 6.853 µM -0.197229686284993 0.427201806576449 no 1923 0.421823900279475 636 20737 An antifungal of unknown mechanism. SGTC_2277 7947813 106.88 µM -0.197848633100089 0.426954617561934 no 1924 0.421581747235362 674 1246798 SGTC_393 acivicin 6.25 µM -0.198374148141898 0.426744764938344 no 1925 0.421376171150531 653 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1 SGTC_2979 9012552 45.46 µM -0.198820986599171 0.426566346348377 no 1926 0.421201389392603 635 17100905 SGTC_1525 8-methoxypsoralen 92.5 µM -0.200568256905691 0.425868821563949 no 1927 0.420518090488496 696 4114 Related to psoralen; DNA damaging agent. SGTC_2954 9074818 52.69 µM -0.202327528005173 0.425166740243147 no 1928 0.419830340371026 668 16648742 SGTC_720 r052-1644 49.9 µM -0.202401110585967 0.425137380420027 no 1929 0.419801580123729 661 1422863 YOR257W CDC31 SGTC_1116 jasmonic acid  1.58368 µM -0.202537659734194 0.425082897717269 no 1930 0.419748210104525 666 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid. SGTC_1263 0774-1208 64.8 µM -0.203038491285173 0.42488307967864 no 1931 0.419552473524865 650 906585 SGTC_1119 parthenolide 318.541 nM -0.203527782399323 0.424687884593828 no 1932 0.419361266435506 686 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs. SGTC_2490 carminic acid 95.39 µM -0.203621653479013 0.424650438295434 no 1933 0.419324585304482 660 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_2835 9006588 71.43 µM -0.203702620694177 0.424618140049416 no 1934 0.419292947060065 632 2345538 SGTC_367 0335-0881 7.1 µM -0.203920337647158 0.424531294127854 no 1935 0.419207875928904 668 23828853 SGTC_1966 st070145 16.1 µM -0.204127935004096 0.424448488261495 no 1936 0.419126762465224 632 3748532 SGTC_1384 3089-0840 101 µM -0.204148501496654 0.424440284936632 no 1937 0.419118726810842 637 1069836 SGTC_2881 9058953 51.95 µM -0.204208672395649 0.424416284851812 no 1938 0.419095217281355 613 17122249 SGTC_3347 9188721 44.724 µM -0.204759564468794 0.4241965661487 no 1939 0.418879990236655 661 44118411 YKL104C | YBL026W GFA1 | LSM2 SGTC_1668 st014914 51.6 µM -0.204799958347249 0.424180456313783 no 1940 0.418864209778617 615 2839556 SGTC_1105 epirubicin 18.1 µM -0.205698924624321 0.423821964563458 no 1941 0.418513049311561 640 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_1738 st035555 74 µM -0.206382546599733 0.423549390465104 no 1942 0.418246051582466 679 5331140 SGTC_1442 4112-3290 3 µM -0.207080640840482 0.423271083727337 no 1943 0.417973440388947 641 704353 SGTC_1936 st074407 74.3 µM -0.207780855683668 0.42299197003062 no 1944 0.417700040669979 624 809813 SGTC_2886 9058944 51.95 µM -0.208198320411741 0.422825582165727 no 1945 0.417537059987311 622 4949929 SGTC_1419 3993-2473 62.6 µM -0.208413540709432 0.422739807730163 no 1946 0.417453042250542 631 704026 SGTC_2877 9040724 71.43 µM -0.209573138559773 0.422277721837812 no 1947 0.417000423188774 648 6463895 SGTC_174 3553-0389 74.3 µM -0.209618641271019 0.422259591727619 no 1948 0.41698266461977 631 738071 SGTC_1012 4112-3522 18 µM -0.209890998570564 0.422151077070769 no 1949 0.4168763739268 651 3112398 SGTC_1821 st053465 65.6 µM -0.210252323511544 0.422007124374399 no 1950 0.416735371926443 657 675086 SGTC_2228 7354201 200 µM -0.211023977652413 0.421699730481734 no 1951 0.416434280586574 642 753451 SGTC_898 1000-0849 28.3 µM -0.21262678756242 0.421061392461356 no 1952 0.415809037864368 643 6751807 SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM -0.213035081770303 0.420898817547919 no 1953 0.415649799700244 655 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_1729 st035615 45.989 µM -0.213144155075556 0.420855388934077 no 1954 0.415607262539896 623 17385451 SGTC_2020 4017018 200 µM -0.214783413572083 0.420202818269534 no 1955 0.414968092583308 667 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope. SGTC_2980 9014342 25.29 µM -0.215130470480026 0.420064686824523 no 1956 0.41483279901671 674 2996599 SGTC_694 1315-0438 43.2 µM -0.215283322551473 0.42000385359088 no 1957 0.414773215732878 675 6793154 SGTC_1208 2323-2347 50.3 µM -0.215550006393901 0.419897721297509 no 1958 0.414669264368418 669 5412760 SGTC_505 gw-5074 63.9 µM -0.216205243854709 0.419636980893974 no 1959 0.414413883104604 647 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases. SGTC_2261 9010538 184.68 µM -0.217573237039806 0.41909272552962 no 1960 0.413880819346781 712 6457250 SGTC_2166 5933061 31.504 µM -0.219391005813284 0.418369766837269 no 1961 0.413172737849417 627 2877375 SGTC_5 0352-0601 109.883 µM -0.220305930625579 0.418005989249938 no 1962 0.412816450827036 657 762456 SGTC_2325 6158266 200 µM -0.220531384281907 0.417916358777425 no 1963 0.412728666419413 628 3623240 SGTC_2200 6600604 21.907 µM -0.220751435559843 0.41782888016461 no 1964 0.412642989733145 683 2904777 SGTC_296 1222-0039 74.9 µM -0.220940716606753 0.417753637121931 no 1965 0.412569296726741 653 5984176 SGTC_1760 st045453 10.4495 µM -0.221839240207867 0.417396496941138 no 1966 0.412219515586026 646 3323419 YIL048W NEO1 SGTC_2440 5628896 157.78 µM -0.223660376919152 0.416672850905086 no 1967 0.41151078975855 639 5522048 SGTC_206 4546-0025 72.014 µM -0.224973506231657 0.416151241456031 no 1968 0.410999942463935 693 6620745 YIL048W NEO1 SGTC_1581 himbacine 57.9 µM -0.225818850405002 0.415815526611711 no 1969 0.410671157618992 684 5281825 An alkaloid muscarinic receptor antagonist. SGTC_3140 9094243 49.47 µM -0.226950037048421 0.415366390162 no 1970 0.410231296540808 666 19291112 SGTC_1911 st060208 74.3 µM -0.227355298576809 0.415205508374685 no 1971 0.410073738342849 651 688783 SGTC_1967 st070177 51.4 µM -0.2281267634135 0.41489928954696 no 1972 0.40977384720121 675 5729214 SGTC_339 3091-4833 71.4 µM -0.228145357672487 0.414891909533963 no 1973 0.409766619714818 633 3240077 SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM -0.229642727961357 0.414297705980053 no 1974 0.409184700958148 644 16725076 SGTC_2932 9016711 44.54 µM -0.229796740817326 0.414236599941718 no 1975 0.409124858706131 678 7117328 SGTC_3213 9129884 49.47 µM -0.231510668095525 0.41355672371697 no 1976 0.408459049298168 665 17190742 SGTC_2871 9038510 12.99 µM -0.231726883808995 0.413470974190181 no 1977 0.408375074694228 701 4945164 SGTC_833 3852-0053 558 µM -0.233490299276395 0.412771771302708 no 1978 0.407690350733659 671 3123681 SGTC_57 miconazole 162.5 nM -0.233653498340348 0.412707076026322 no 1979 0.40762699570664 658 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_1772 st048439 82.2 µM -0.234437069457854 0.412396486280904 no 1980 0.407322841548559 631 2927068 YDL195W SEC31 SGTC_912 3474-0017 2.18 µM -0.236266932205815 0.411671384297412 no 1981 0.406612772444637 685 3360550 SGTC_1854 st056233 32.9 µM -0.237720122481142 0.411095757356584 no 1982 0.406049087759549 682 5393174 SGTC_1381 2324-0066 62.1 µM -0.238639253216533 0.410731776832163 no 1983 0.405692662337808 692 10885928 SGTC_485 niflumic acid 177 µM -0.240023599084774 0.410183713855246 no 1984 0.405155980930749 662 4488 A COX2 inhibitor. SGTC_2086 5274770 176.623 µM -0.241397155169599 0.409640095886469 no 1985 0.404623658707855 655 689278 SGTC_2716 st080858 38.6235 µM -0.24271435839679 0.409118944028958 no 1986 0.40411334180822 646 5296050 SGTC_64 000l-0018 272.079 µM -0.24323932520336 0.408911285458702 no 1987 0.403910002181688 656 6811119 SGTC_1500 4488-1866 171 µM -0.243983319683366 0.408617030977597 no 1988 0.403621869284478 696 2900003 SGTC_1762 st045503 25.4615 µM -0.244005919206653 0.408608093529694 no 1989 0.403613117797798 675 4645554 SGTC_1176 0848-0131 83.3 µM -0.244181162120207 0.408538791716362 no 1990 0.403545258003629 672 6769040 SGTC_3022 9087993 49.47 µM -0.245364188300358 0.408071025417989 no 1991 0.403087227595709 632 17173644 SGTC_3183 9108214 49.47 µM -0.245617859167137 0.40797074147244 no 1992 0.402989031528127 661 4974831 SGTC_1684 st024538 14.6195 µM -0.246499308068737 0.407622324347306 no 1993 0.402647869999643 641 6732859 SGTC_2630 antimycin a 100 µM -0.248049124479263 0.407009893738091 no 1994 0.4020481991853 672 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain. SGTC_2723 salbutamol 83.58 µM -0.248399768272708 0.4068713636476 no 1995 0.401912556427504 677 9884233 β2-adrenoceptor agonist SGTC_1375 2910-0797 186 µM -0.248700037850704 0.406752744337609 no 1996 0.401796409779385 654 742508 SGTC_972 1319-0219 195 µM -0.251192777484823 0.405768336968354 no 1997 0.400832534160725 664 23903702 SGTC_419 nsc-638432 893 µM -0.251238047432136 0.405750464909265 no 1998 0.400815035046348 669 368090 SGTC_686 1319-0111 510 µM -0.251441667541754 0.405670080440959 no 1999 0.400736328081264 702 4562600 SGTC_2023 5144124 124 µM -0.252456213730489 0.405269620626351 no 2000 0.400344227269699 657 2830192 SGTC_1934 st074720 32.6 µM -0.255356084857172 0.404125536910662 no 2001 0.399224042920116 641 17250992 SGTC_209 4077-0173 175.592 µM -0.255677874783177 0.403998631741725 no 2002 0.399099790402385 636 15993494 SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM -0.256412797647752 0.403708836118598 no 2003 0.398816053506389 671 616764 SGTC_74 000s-0487 160.283 µM -0.257427843088897 0.403308669181001 no 2004 0.398424255639439 655 677548 SGTC_605 1315-0399 119 µM -0.258250840917842 0.402984288515755 no 2005 0.398106661448089 656 24020461 SGTC_2129 girgensonine 121.053 µM -0.259061385882278 0.402664881335534 no 2006 0.397793938776101 683 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_2271 7849410 118.62 µM -0.260281479091044 0.402184208181615 no 2007 0.39732332896791 694 972430 SGTC_1631 benzylvanillin 81.9 µM -0.260920572394513 0.401932487214691 no 2008 0.397076879872624 663 75506 SGTC_2839 9003951 25.97 µM -0.261079842649028 0.401869761446042 no 2009 0.397015467987517 683 2990634 SGTC_1714 st033236 13.627 µM -0.263383141828722 0.40096293122892 no 2010 0.396127641450024 687 2916566 SGTC_2744 captopril 92.04 µM -0.26353926168487 0.400901484642253 no 2011 0.396067483140214 657 44093 angiotensin-converting enzyme (ACE) inhibitor  SGTC_2796 7949634 45.45 µM -0.265344724397811 0.400191058315886 no 2012 0.395371956895832 653 2971588 SGTC_557 1315-0110 16.2 µM -0.266136127289608 0.399879755405215 no 2013 0.39506718621169 652 6833801 SGTC_2908 7930301 100 µM -0.266321133748684 0.399806991210655 no 2014 0.394995949139339 681 2223178 SGTC_3116 9124943 49.47 µM -0.266506020571062 0.399734277545695 no 2015 0.394924761639755 633 41905195 YPL160W CDC60 SGTC_3349 9149703 23.001 µM -0.267298834300719 0.399422513316356 no 2016 0.394619542109084 672 4910494 SGTC_272 doxorubicin 8.13 µM -0.267461195879378 0.399358674530931 no 2017 0.394557043691069 654 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM -0.268938271359358 0.39877802851338 no 2018 0.393988592633696 662 688788 SGTC_1237 0330-0133 46.1 µM -0.269265748035545 0.39864932602236 no 2019 0.393862594089658 701 X1237 YHR072W ERG7 SGTC_2955 9076254 12.21 µM -0.269424848048144 0.398586801674719 no 2020 0.393801383449356 659 16459619 SGTC_1694 st024011 44.9 µM -0.270071342813243 0.398332763978994 no 2021 0.393552684149886 700 2787533 SGTC_758 0868-0029 16 µM -0.272009450148045 0.397571450537385 no 2022 0.392807376527765 643 762687 SGTC_930 2810-3379 265 µM -0.27207125739191 0.3975471782599 no 2023 0.392783614732217 710 1015764 SGTC_1255 0566-0045 221 µM -0.272485631114465 0.397384460107328 no 2024 0.392624319073757 674 2788469 SGTC_2294 7971431 200 µM -0.274021890080553 0.396781350997925 no 2025 0.392033899713702 703 5741572 SGTC_2989 9073649 71.4286 µM -0.274190534665702 0.396715159014618 no 2026 0.391969100866583 703 21367202 SGTC_2179 6298986 200 µM -0.274700983559367 0.396514829043792 no 2027 0.391772987725786 672 738374 SGTC_617 3770-0098 35 µM -0.275525541520941 0.396191282042721 no 2028 0.391456252800705 681 5962639 SGTC_2115 tiliquinol 12.7705 µM -0.276328890583128 0.395876125919391 no 2029 0.391147733981187 695 71208 A bioactive hydroxyquinoline. SGTC_511 blebbistatin 171 µM -0.277252220395704 0.395513985076266 no 2030 0.390793222254264 676 3476986 A myosin inhibitor. SGTC_3257 9139206 32.98 µM -0.277299964316685 0.395495261797304 no 2031 0.390774893479792 683 4910041 SGTC_2708 st078559 56 µM -0.277951572604641 0.395239750906054 no 2032 0.390524766924023 661 17250902 SGTC_443 clozapine 122 µM -0.278163913594945 0.39515649674748 no 2033 0.390443267427862 684 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_2714 st079313 56.9 µM -0.278257596001132 0.395119767490172 no 2034 0.390407312316329 656 2939799 SGTC_441 propafenone 146 µM -0.279212152962992 0.394745575706145 no 2035 0.390041008830813 650 4932 Slows the influx of sodium ions into the cardiac muscle. SGTC_1188 1403-0014 4.57 µM -0.281304051124646 0.393925879603926 no 2036 0.389238601685926 677 9614867 SGTC_245 methotrexate 289.6 µM -0.281870580983631 0.39370396939907 no 2037 0.389021374111711 673 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2 SGTC_1009 4106-0057 9.87 µM -0.283379991264224 0.39311290083938 no 2038 0.388442782344204 691 2928005 SGTC_1352 1496-0991 99 µM -0.283490998317526 0.393069441398544 no 2039 0.388400240533695 697 3000039 SGTC_2487 5918373 44.05 µM -0.283533388627652 0.393052845875193 no 2040 0.388383995427825 672 2876279 SGTC_2103 5378138 10 µM -0.28416116535248 0.392807098248262 no 2041 0.38814343738977 678 244142 SGTC_824 1304-0008 100 µM -0.285406033845845 0.392319912138352 no 2042 0.387666542679345 662 768245 SGTC_21 0849-0113 22.993 µM -0.287192987409027 0.391620873158442 no 2043 0.386982277748333 668 1560156 SGTC_1856 st057054 55.7 µM -0.287456887242961 0.39151766768232 no 2044 0.386881254237673 703 1266018 SGTC_2814 7977482 42.97 µM -0.287512348888374 0.391495978811743 no 2045 0.386860023936283 675 6456762 SGTC_2909 7941780 10.49 µM -0.288866897477751 0.390966372949947 no 2046 0.386341618153167 687 1243215 SGTC_795 0685-0265 78 µM -0.290242312974916 0.390428815307718 no 2047 0.385815433815024 666 302754 SGTC_2601 securinine 100 µM -0.29137459565478 0.389986439062808 no 2048 0.385382420887129 663 442872 A GABA receptor antagonist. SGTC_87 0100-0052 35.5 µM -0.292041595687368 0.389725912670621 no 2049 0.385127410382721 681 200187 YGR083C | YDR527W GCD2 | RBA50 SGTC_2822 7994718 71.43 µM -0.292993911047741 0.389354029630815 no 2050 0.384763402925224 684 1018011 SGTC_1835 st008666 49.2 µM -0.29317097603311 0.389284896190062 no 2051 0.384695733827248 677 690455 SGTC_1834 st055981 52.8 µM -0.29371520938249 0.389072427091163 no 2052 0.384487765636868 701 471719 YDL150W RPC53 SGTC_86 0417-1630 471.922 µM -0.293801454385211 0.389038760021653 no 2053 0.384454811836145 666 3634867 SGTC_1676 st018489 23.4 µM -0.293958786577413 0.388977345115641 no 2054 0.384394698113409 673 3696235 SGTC_2454 5-benzylidenerhodanine 10.36 µM -0.294115939441893 0.388916002979818 no 2055 0.384334655683876 702 1273210 SGTC_641 4092-0595 30 µM -0.294225455118948 0.388873256904076 no 2056 0.38429281534265 671 786260 SGTC_1897 st060201 15 µM -0.294991189547553 0.388574413639097 no 2057 0.384000305059135 671 611878 SGTC_205 1486-1330 71.903 µM -0.295464043682254 0.388389905719674 no 2058 0.383819707930266 677 4118834 SGTC_2917 7979103 53.79 µM -0.295604796262757 0.38833498885432 no 2059 0.383765955183403 703 2980565 SGTC_1209 2323-2347 50.3 µM -0.297521290256901 0.387587460703723 no 2060 0.383034278110815 656 5412760 SGTC_612 0302-0167 22.4 µM -0.297641662584071 0.387540523371857 no 2061 0.38298833638495 672 235821 SGTC_727 3032-0951 202 µM -0.298386767577912 0.387250017775768 no 2062 0.382703993642735 689 3652836 SGTC_2416 tofa 880 nM -0.299014170405638 0.3870054514952 no 2063 0.382464616749358 676 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_308 4092-1169 104 µM -0.299374746803435 0.386864916428278 no 2064 0.382327064112706 678 2268590 YDL196W YDL196W SGTC_268 camptothecin 39.6153 µM -0.300492699057968 0.386429287606707 no 2065 0.381900682287986 691 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_2240 6690706 185.951 µM -0.303647470726059 0.385200751327821 no 2066 0.380698240823321 651 805876 SGTC_995 3931-2021 34.6 µM -0.304508469183154 0.38486565937928 no 2067 0.380370270723453 683 730143 SGTC_2009 4012297 12.05 µM -0.305098628701862 0.38463602487209 no 2068 0.380145517790535 702 45595307 SGTC_1393 3470-5649 58.2 µM -0.306119751300866 0.384238795751169 no 2069 0.379756734992747 695 4108395 SGTC_2950 9072895 21.46 µM -0.308199029797576 0.383430307265247 no 2070 0.378965445333886 693 17332245 SGTC_122 0236-0016 402.397 µM -0.308875691060398 0.383167309456635 no 2071 0.378708044484377 680 6808838 SGTC_1787 fluconazole 80 µM -0.309633530397175 0.382872824100371 no 2072 0.378419827491351 691 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C SGTC_2427 5545055 42.75 µM -0.309658662785522 0.382863059178149 no 2073 0.378410270447096 688 5372858 SGTC_2450 5739737 12.93 µM -0.309705044812687 0.382845038130235 no 2074 0.378392633039465 669 2262825 SGTC_787 4152-0075 138 µM -0.310863220594173 0.382395128455817 no 2075 0.377952302910415 655 9566539 SGTC_1355 1499-0035 1.68 µM -0.31095125419044 0.382360937049775 no 2076 0.377918839643449 689 1548538 SGTC_62 0180-0423 3.232 µM -0.311338012813315 0.382210734572351 no 2077 0.377771836090733 707 30102 YGL099W LSG1 SGTC_2972 9093619 59.92 µM -0.311621158541337 0.382100782675687 no 2078 0.37766422610983 669 25236256 SGTC_84 0443-0269 128.823 µM -0.311785228611574 0.382037074903096 no 2079 0.377601875364909 681 6150058 SGTC_2006 4011487 200 µM -0.311914530789776 0.38198686961863 no 2080 0.377552739538827 676 45595294 SGTC_2426 5582046 32.21 µM -0.312196328776637 0.381877460333035 no 2081 0.377445660994558 699 2251934 SGTC_1635 st007035 42.4 µM -0.312859956290752 0.381619841367517 no 2082 0.377193530812484 699 3716403 SGTC_2039 Aminomethylbenzodioxan 200 µM -0.313113828127392 0.381521302651696 no 2083 0.377097091818036 700 15053 SGTC_566 0958-0068 16.5 µM -0.315860915436975 0.380455530762496 no 2084 0.376054039620678 711 6815365 SGTC_1047 2043-3044 82 µM -0.315949677384667 0.380421109372818 no 2085 0.376020352303235 746 669592 SGTC_70 0141-0289 43.283 µM -0.315990149984299 0.380405414638029 no 2086 0.376004992281137 662 352408 SGTC_1545 lovastatin 49.4 µM -0.316841024371974 0.380075502503527 no 2087 0.375682116865126 666 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12 SGTC_672 1441-0018 53.7 µM -0.317443237712721 0.379842057187823 no 2088 0.37545365172097 680 251141 SGTC_1293 1000-1278 195 µM -0.317645798029315 0.379763545419944 no 2089 0.375376815058146 711 678847 SGTC_2351 9026858 72.31 µM -0.318591059528181 0.379397230491142 no 2090 0.375018316953344 698 1409300 SGTC_2436 5633522 8.09 µM -0.318800552037881 0.379316061000963 no 2091 0.374938879819281 713 5724242 SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM -0.319052378806682 0.379218495816296 no 2092 0.374843397046166 700 521171 SGTC_2532 xanthone 78.9 µM -0.320652829554095 0.378598613609307 no 2093 0.374236748809104 707 7020 An insecticide. SGTC_2418 pentamidine 31.67 µM -0.321845402320935 0.378136912495741 no 2094 0.373784908346938 708 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_591 4299-0174 154 µM -0.322535341368192 0.377869883974217 no 2095 0.373523584250042 698 5509088 SGTC_1149 3909-7961 23.3 µM -0.322659431537578 0.377821863288985 no 2096 0.373476589523078 671 735261 SGTC_2058 5236698 133 µM -0.324556495271129 0.377087968888779 no 2097 0.372758378922254 667 766665 SGTC_2249 haloperidol 116.36 µM -0.324743417137617 0.377015680632598 no 2098 0.372687635937815 701 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_3318 9139014 38.6185 µM -0.325456368244448 0.37674000078727 no 2099 0.372417849865028 701 16643984 SGTC_3354 9151612 71.43 µM -0.325574400989879 0.376694366621382 no 2100 0.372373191420211 708 27261949 SGTC_321 4534-3890 65.3 µM -0.326305783373211 0.376411635858047 no 2101 0.372096506497893 695 699746 SGTC_2865 9030313 51.95 µM -0.326763738790361 0.376234637601337 no 2102 0.371923293710988 675 42562754 SGTC_812 4251-0442 148 µM -0.328578731755747 0.375533405121199 no 2103 0.371237062923586 704 5723007 SGTC_1877 wortmannin 25 µM -0.328734055282795 0.375473414083762 no 2104 0.371178355618536 707 312145 A covalent inhibitor of PI 3-kinase. SGTC_3074 9116018 49.47 µM -0.329061861232312 0.375346814565616 no 2105 0.371054465337283 696 17027303 SGTC_1879 gemcitabine 100 µM -0.33112157482652 0.374551655443569 no 2106 0.370276327825975 682 60750 A nucleoside analog which inhibits DNA replication. SGTC_2046 4110841 106 µM -0.331479546880492 0.374413513460508 no 2107 0.370141143888208 725 44119630 YMR134W ERG29 SGTC_1961 st076550 68.7 µM -0.331920583566706 0.374243338870211 no 2108 0.369974613625047 691 1579337 SGTC_2860 9025725 38.96 µM -0.332380063434731 0.374066074011628 no 2109 0.369801145360685 718 40546248 SGTC_2465 5809242 33.21 µM -0.333542634983108 0.373617679160401 no 2110 0.369362356005472 715 2731748 SGTC_1774 st048371 48.465 µM -0.336467597487704 0.372490301416872 no 2111 0.368259141056417 683 4242727 SGTC_3353 9151644 39.2805 µM -0.337072576102508 0.372257258485724 no 2112 0.368031095021166 700 4909158 SGTC_4 0960-0234 25.671 µM -0.339967890360069 0.371142607642838 no 2113 0.366940354502655 668 6821112 SGTC_1975 st070967 30.8 µM -0.339995903548433 0.37113182826311 no 2114 0.366929806431293 722 261391 SGTC_546 peri-Naphthalide 147 µM -0.342025588084188 0.370351082085264 no 2115 0.366165817875612 682 223824 A penicillin ester. SGTC_3298 9116858 71.43 µM -0.342716259654574 0.370085527292987 no 2116 0.365905964654049 737 2506942 SGTC_2283 7944793 200 µM -0.342990314500213 0.3699801737011 no 2117 0.365802873299889 669 2970533 SGTC_1452 4194-0072 190 µM -0.343399926923154 0.369822726549713 no 2118 0.365648807248143 714 1343545 SGTC_2429 5902844 64.44 µM -0.345525220051498 0.369006155523799 no 2119 0.364849776775711 712 1927790 YGL093W | YPR107C SPC105 | YTH1 SGTC_1928 4'-methoxychalcone 40.3 µM -0.347264957331485 0.368338160712786 no 2120 0.364196137280195 732 641818 SGTC_2560 caryophyllene 100 µM -0.348459331489094 0.36787979533273 no 2121 0.363747625481355 683 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor. SGTC_230 MPP+ 141.667 µM -0.348529155774482 0.367853004655535 no 2122 0.363721410810112 708 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death. SGTC_1075 aripiprazole 15.2 µM -0.348742682885032 0.367771081048293 no 2123 0.3636412486352 699 60795 An atypical antipschotic. YIL048W NEO1 SGTC_2966 9084041 48.03 µM -0.348759156114866 0.36776476104027 no 2124 0.363635064516574 699 17741380 SGTC_2236 dapsone 200 µM -0.349185882241423 0.367601058659634 no 2125 0.363474882148244 694 2955 A bacterial DFR inhibitor. An anti-cancer agent. SGTC_2719 novobiocin 32.65 µM -0.350178900180505 0.36722020631136 no 2126 0.363102220360591 711 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication. SGTC_2475 5812728 15.03 µM -0.350342656171282 0.3671574134815 no 2127 0.363040778116187 701 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2 SGTC_2082 5219693 150 µM -0.350744454321307 0.367003357577809 no 2128 0.362890035942716 718 2834649 SGTC_2390 9097792 176.6 µM -0.351430939643336 0.366740197570572 no 2129 0.362632537156029 686 4497149 SGTC_2833 9001315 45.46 µM -0.351432503167527 0.366739598274436 no 2130 0.362631950753192 679 2989378 SGTC_668 1682-0499 62.6 µM -0.351964248552523 0.366535800032086 no 2131 0.362432537293178 684 682214 SGTC_2471 5466956 24.79 µM -0.35250917454916 0.366326989187049 no 2132 0.362228219599397 703 724419 SGTC_1339 1486-1321 22.7 µM -0.354234422337188 0.365666150650883 no 2133 0.361581604311403 701 3469382 SGTC_132 0417-1715 25.805 µM -0.356434372246132 0.364824060522577 no 2134 0.360757646034274 724 6769098 SGTC_1517 deoxycholic acid methyl ester 49.2 µM -0.35673092412641 0.364710597051334 no 2135 0.360646626291327 730 229346 A bile salt which induces apoptosis. SGTC_460 trequinsin 123 µM -0.357957036801024 0.364241600961703 no 2136 0.36018773283194 687 5537 A vasodilator. SGTC_2403 6032726 181.2 µM -0.358470528658111 0.364045247311159 no 2137 0.359995609586059 705 2881040 SGTC_499 genistein 192 µM -0.358691042969394 0.363960936009066 no 2138 0.359913114892431 709 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger. SGTC_1903 st060211 78.3 µM -0.358697117647939 0.363958613513501 no 2139 0.359910842439536 689 688960 SGTC_695 3505-6186 243 µM -0.359294473090138 0.363730254594586 no 2140 0.359687404258676 721 1819379 SGTC_1143 3454-2408 5.08 µM -0.362187403996268 0.362625021937025 no 2141 0.358605995828357 696 X1143 SGTC_883 0850-0245 24.6 µM -0.362305972118516 0.362579747797646 no 2142 0.358561697904896 722 6823229 YPR165W RHO1 SGTC_2915 7971052 15.16 µM -0.362557751233635 0.36248361464726 no 2143 0.358467637685112 714 5741558 SGTC_2127 5253358 187.912 µM -0.362653112423285 0.362447206537276 no 2144 0.358432014674468 706 20612 SGTC_1069 diphenylcyclopropenone 8.49 µM -0.364167373411757 0.361869241183598 no 2145 0.357866514454753 750 65057 A dermal irritant. YDR527W RBA50 SGTC_2100 5377183 190 µM -0.366841916755864 0.360849187517339 no 2146 0.356868469502087 694 2844202 SGTC_1251 0490-5699 265 µM -0.367485018718216 0.360604059784992 no 2147 0.356628632333132 728 3883818 SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM -0.368429748066361 0.360244066237266 no 2148 0.356276409649673 688 6708739 YPR165W RHO1 SGTC_1638 st008370 60.6 µM -0.369826259238938 0.359712146086389 no 2149 0.35575597410816 685 24207134 SGTC_509 pifithrin 175 µM -0.370883849431832 0.35930949896359 no 2150 0.355362022456786 722 4817 A p53 inhibitor. SGTC_1150 3909-7983 10.9 µM -0.372143757344636 0.358830029063835 no 2151 0.354892909273205 698 23965914 SGTC_2333 9017922 200 µM -0.372252642058486 0.358788602381884 no 2152 0.354852377533328 690 3163164 SGTC_2401 5128683 200 µM -0.373891901658643 0.358165124594004 no 2153 0.35424237087893 754 708373 SGTC_1182 1222-0449 220 µM -0.374407126470413 0.357969241427869 no 2154 0.354050720865679 697 658318 SGTC_2820 7989630 71.43 µM -0.3760151693106 0.357358120757034 no 2155 0.353452809357861 688 2984098 SGTC_3287 9117173 37.0625 µM -0.376359809852228 0.357227191078814 no 2156 0.353324710164181 689 2789709 SGTC_249 wiskostatin 11.211 µM -0.377046177513409 0.356966488621067 no 2157 0.353069644170448 704 2775510 A n-wasp and actin depolymerizer. SGTC_330 1488-0319 80.1 µM -0.377084810341599 0.356951816730079 no 2158 0.353055289509996 695 6846614 SGTC_2904 7225135 42.03 µM -0.377550255482529 0.356775067627751 no 2159 0.352882362181676 730 4446116 SGTC_2870 9038528 12.99 µM -0.377808937938727 0.35667684830531 no 2160 0.352786266748124 724 6463316 SGTC_3137 9097352 49.47 µM -0.37803876930387 0.356589591445367 no 2161 0.352700896804529 765 44120435 SGTC_3162 9099653 49.47 µM -0.379080764253506 0.356194086003277 no 2162 0.352313945036429 687 25237511 SGTC_1215 3852-0577 11.2 µM -0.37956696652835 0.356009593235824 no 2163 0.35213344284806 684 2884876 SGTC_1894 3',6'-dihydroxyflavone 78.7 µM -0.379952508855353 0.355863320533571 no 2164 0.351990334257452 697 688662 SGTC_585 0kpi-0023 191 µM -0.380227106271682 0.355759152674195 no 2165 0.351888419839884 719 64601 SGTC_3301 9125354 19.7965 µM -0.380532375374697 0.355643362226821 no 2166 0.351775134385039 679 41905162 SGTC_1557 sumaresinolic acid 42.3 µM -0.383688860319648 0.354446870734108 no 2167 0.350604535015369 713 9982268 A natural terpine and antifungal of unknown mechanisn. SGTC_1108 betulinic acid 729.144 nM -0.384050522792283 0.354309871018897 no 2168 0.350470500831229 691 64945 Apoptosis-inducing agent of unknown mechanism. SGTC_2977 9011197 71.43 µM -0.384060570914489 0.354306065004526 no 2169 0.350466777205295 750 2704722 SGTC_614 0462-0418 107 µM -0.38490084315225 0.353987839324964 no 2170 0.350155440597643 703 5188303 SGTC_1195 1502-0147 41.1 µM -0.385305903790501 0.353834472241028 no 2171 0.350005393993996 708 817940 SGTC_2295 7971645 200 µM -0.38642130027519 0.353412275128506 no 2172 0.34959233877949 715 2978226 YKL099C UTP11 SGTC_2897 9048598 12.99 µM -0.387035060964213 0.353180032824843 no 2173 0.349365125938092 700 6467404 SGTC_2043 5101342 149 µM -0.387972573935281 0.352825390716394 no 2174 0.349018164923083 709 678451 SGTC_410 α-linolenic acid 100 µM -0.388368331561358 0.352675722002781 no 2175 0.348871738176575 721 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_1050 3232-1156 69.3 µM -0.388999464927676 0.352437085423108 no 2176 0.348638271100904 730 700529 SGTC_1808 st050063 61.5 µM -0.391405484449678 0.351527883564513 no 2177 0.347748769517621 750 4011993 SGTC_2177 5811945 192 µM -0.391807072930032 0.351376211288139 no 2178 0.347600384316043 721 5343475 SGTC_1089 terbinafine 2.25 µM -0.39220047006271 0.351227655670856 no 2179 0.347455048418195 717 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_365 0121-0052 13.6 µM -0.393321865849525 0.350804316168166 no 2180 0.34704088518402 693 3101739 SGTC_1898 st060199 18.6 µM -0.393333060869639 0.350800090854985 no 2181 0.347036751465927 692 688866 SGTC_2550 chrysin dimethyl ether 71.87 µM -0.393901658951143 0.350585510342515 no 2182 0.346826822762088 723 88881 An O-methylated flavonoid and antioxidant. SGTC_351 caspofungin 25 nM -0.394455321350306 0.350376612137426 no 2183 0.346622453548576 695 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1 SGTC_2900 5328528 85.29 µM -0.394556918923799 0.350338284031157 no 2184 0.34658495644924 690 795359 SGTC_911 3456-4043 236 µM -0.394748447067719 0.35026603338877 no 2185 0.346514272334737 702 914281 SGTC_3265 9137266 49.47 µM -0.397184748303247 0.349347454987907 no 2186 0.345615614131008 689 17224265 SGTC_1104 tacrolimus 29.8 µM -0.397343569475944 0.349287603908896 no 2187 0.345557061212853 710 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41 SGTC_2564 betulinic acid 100 µM -0.397487895893391 0.349233218366499 no 2188 0.345503855309478 751 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14 SGTC_2722 naftopidil 47.16 µM -0.39758861631395 0.349195266409373 no 2189 0.345466726555875 750 4418 An a1-adrenergic receptor antagonist or alpha blocker.  SGTC_1658 st012944 20 µM -0.397938785551417 0.349063332630607 no 2190 0.345337654598902 736 24207260 SGTC_373 0844-0104 25.9 µM -0.398419137482518 0.348882379405039 no 2191 0.345160626717706 715 5375804 SGTC_825 1988-2224 89.6 µM -0.399107706364454 0.348623048781665 no 2192 0.344906922097839 718 1180859 SGTC_2662 daunorubicin 22.37 µM -0.399404551985764 0.34851127181216 no 2193 0.344797570217184 703 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_3153 9100258 49.47 µM -0.399991258769085 0.348290386559805 no 2194 0.344581477529639 745 25236848 SGTC_440 fluspirilene 35.1 µM -0.400152599226673 0.34822965360239 no 2195 0.344522062366388 728 3396 An atypical antipsychotic. SGTC_2620 irigenin 100 µM -0.40079611530684 0.347987455294064 no 2196 0.344285119601828 717 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro. SGTC_1908 st060353 56.5 µM -0.401584937902978 0.347690652975806 no 2197 0.343994758311929 764 4227716 SGTC_781 4335-2806 94.4 µM -0.401887501875976 0.34757683503625 no 2198 0.343883410559973 756 845254 SGTC_774 k060-0086 136 µM -0.402215766227311 0.347453364716396 no 2199 0.343762620024007 754 5911235 SGTC_2139 5578692 56.4705 µM -0.402276404581825 0.34743055853656 no 2200 0.343740308839152 740 650991 YMR113W FOL3 SGTC_785 1270-0111 65.3 µM -0.402710012224624 0.347267494124433 no 2201 0.34358078376012 695 6741994 SGTC_3241 9133421 49.47 µM -0.402773382770709 0.347243665082853 no 2202 0.343557471947537 724 17018221 SGTC_2692 st077426 47.7 µM -0.402794777460642 0.347235620236355 no 2203 0.343549601722027 754 25238571 SGTC_1664 st014217 9.02 µM -0.403458283559018 0.346986162386305 no 2204 0.343305558830062 724 3982782 SGTC_3000 9075062 71.4286 µM -0.403732111467794 0.346883230850298 no 2205 0.343204861754183 707 17057871 SGTC_23 0213-0011 39.996 µM -0.404085351920394 0.346750464937534 no 2206 0.343074978068484 748 627608 SGTC_447 ml7 120 µM -0.406491168503105 0.345846736685689 no 2207 0.342190872356967 725 4216 Selective myosin light chain kinase inhibitor. SGTC_1000 4048-0884 8.67 µM -0.406520183711321 0.345835842670266 no 2208 0.342180214917943 740 13040088 SGTC_318 1488-0629 67.2 µM -0.408346693914892 0.345150320561521 no 2209 0.341509581423368 733 3662576 SGTC_207 4185-0010 4.486 µM -0.408533274116218 0.34508032220802 no 2210 0.341441103525395 708 3761753 SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM -0.40931805480588 0.344785958052332 no 2211 0.341153133715347 689 6708514 SGTC_59 0330-0160 1.33 µM -0.40952178127756 0.344709557441937 no 2212 0.341078392820278 737 4293482 SGTC_2414 st077232 92.9 µM -0.410611117837665 0.344301146740327 no 2213 0.340678855048407 689 729801 SGTC_3002 9075603 71.4286 µM -0.41076406051244 0.344243820463983 no 2214 0.34062277430524 700 20105405 SGTC_1316 1272-0050 65.9 µM -0.410849093867443 0.344211949641265 no 2215 0.340591595952364 748 7340392 SGTC_3046 9092212 49.47 µM -0.411090063724963 0.344121639239181 no 2216 0.340503247796933 697 25236637 SGTC_2384 9036245 200 µM -0.413045718376438 0.343389030506035 no 2217 0.339786559052952 734 6462766 SGTC_1852 st056254 31.4 µM -0.415281096522824 0.342552354681039 no 2218 0.33896806894102 724 442583 SGTC_2799 7812892 81.82 µM -0.416829085406694 0.341973412675208 no 2219 0.338401713234228 748 20205235 SGTC_1359 1582-0056 520 nM -0.417156733562298 0.341850921074657 no 2220 0.338281884889736 749 3661189 SGTC_1356 1502-0781 85.8 µM -0.41864193403168 0.34129588626731 no 2221 0.337738918998431 723 567702 SGTC_2388 9080168 200 µM -0.418982769462099 0.341168560899803 no 2222 0.337614362511679 728 15943073 SGTC_1559 coumarin 343 70.1 µM -0.419086539923727 0.34112979911816 no 2223 0.337576443682315 749 108770 A hepatotoxic, DNA x-linker. SGTC_289 k017-0060 526 µM -0.419127900527978 0.341114349999031 no 2224 0.337561330537611 733 5512909 SGTC_1225 1216-0074 20.6 µM -0.420810450753096 0.34048610558247 no 2225 0.336946749849111 725 4241466 SGTC_2212 7123476 200 µM -0.421172803734451 0.340350865084739 no 2226 0.33681445100813 718 1085715 SGTC_2052 5265182 7.135 µM -0.421257696574945 0.340319183616049 no 2227 0.336783458667914 739 1239884 SGTC_236 1509-0011 5.31 µM -0.42177403685103 0.340126512987083 no 2228 0.33659497909347 766 3107280 SGTC_2107 5363541 170.161 µM -0.422381959920626 0.339899722050325 no 2229 0.336373121683191 707 244052 SGTC_2224 6650123 117.647 µM -0.422701991207937 0.339780354892648 no 2230 0.336256351312037 723 2908370 SGTC_690 glyoxal 20.3 µM -0.422899161856413 0.339706821017738 no 2231 0.336184417178279 732 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins. SGTC_1483 3453-0561 55.9 µM -0.423618761949765 0.339438501291477 no 2232 0.335921935047505 749 4546991 SGTC_1870 st057514 26.5 µM -0.424965323553418 0.338936622997051 no 2233 0.335430976746151 699 5393161 SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM -0.430255870350029 0.336967551994684 no 2234 0.33350476218967 726 5379071 SGTC_771 0250-0039 27.3 µM -0.430835123161104 0.336752231717083 no 2235 0.333294129510528 736 3005115 SGTC_284 0988-0104 32.6 µM -0.431237382328666 0.336602735117659 no 2236 0.333147887638011 735 4666532 SGTC_2557 derrustone 83.84 µM -0.432017601623458 0.336312846101734 no 2237 0.332864310173979 777 629853 An antioxidant. SGTC_1091 telmisartan 47.6 µM -0.434001091713422 0.335576322464644 no 2238 0.332143824140938 754 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension. SGTC_550 4123-0385 25.7 µM -0.436361808055805 0.334700547401279 no 2239 0.331287122068319 753 5731123 SGTC_2219 9098279 200 µM -0.436944173934321 0.334484640139903 no 2240 0.331075917444318 734 902349 SGTC_2952 9073731 13.78 µM -0.437064076941676 0.334440193898252 no 2241 0.331032439303259 748 16457353 SGTC_1325 1431-0015 227 µM -0.438608108807279 0.333868052037218 no 2242 0.330472760231613 728 1103340 SGTC_162 k030-0015 37.8 µM -0.438925839950844 0.333750364430884 no 2243 0.330357636347789 741 1809920 YMR134W ERG29 SGTC_3120 9124077 49.47 µM -0.439619640429606 0.333493437609909 no 2244 0.330106306652297 739 18774327 YGL155W CDC43 SGTC_1454 4239-0054 42.6 µM -0.441023845848435 0.332973674079407 no 2245 0.329597866931436 750 1340767 SGTC_2173 5763948 167 µM -0.44173863230028 0.332709220574477 no 2246 0.329339175341456 728 2867177 SGTC_2218 6965428 192.983 µM -0.442113017631221 0.332570740358039 no 2247 0.329203712440606 726 675684 SGTC_3176 9106582 49.47 µM -0.442306294605917 0.332499258683785 no 2248 0.32913378829378 725 17018027 SGTC_2106 5357045 167.29 µM -0.443059748919208 0.33222065885334 no 2249 0.328861259110638 732 668842 SGTC_699 0375-0592 111 µM -0.443787002652378 0.331951834951282 no 2250 0.328598293113696 718 762578 SGTC_1795 st049545 62.3 µM -0.44398013007076 0.331880461372596 no 2251 0.328528474871493 698 5291882 SGTC_3 0833-0587 95.581 µM -0.445988597069084 0.331138559692365 no 2252 0.327802741411264 728 5382644 SGTC_894 0960-0238 55.9 µM -0.44617398098622 0.331070114625878 no 2253 0.327735788061147 754 6741907 YDL195W SEC31 SGTC_767 0929-0023 86 µM -0.447159186937893 0.33070646430898 no 2254 0.327380063536863 726 1204563 SGTC_2290 7904846 200 µM -0.44748917922654 0.330584696231245 no 2255 0.327260949504762 717 2962154 SGTC_1357 1503-1303 39.5 µM -0.448701711735646 0.330137422408944 no 2256 0.326823424836944 726 292895 SGTC_2710 st078562 53.7235 µM -0.44870620790606 0.330135764331945 no 2257 0.326821802901978 764 17250908 SGTC_2757 clomiphene 4.22 µM -0.448792068405996 0.330104101732765 no 2258 0.326790830471867 764 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined. SGTC_37 0566-0070 1.56 µM -0.449347835286055 0.329899182166249 no 2259 0.326590377739221 742 1626686 SGTC_1770 st043884 66.3 µM -0.449983327773799 0.329664929119544 no 2260 0.326361231097537 766 670149 SGTC_1709 st033179 39.1045 µM -0.450188638842276 0.329589262336701 no 2261 0.326287213786007 725 573381 SGTC_1532 4',5'-dihydroxyflavone 78.7 µM -0.452503350059593 0.328736665691768 no 2262 0.32545320419669 746 165521 SGTC_1547 harmine 94.2 µM -0.452659219630433 0.328679284926856 no 2263 0.325397074438019 719 5280953 A monoamine oxidase inhibitor YHR072W ERG7 SGTC_1892 st058411 7.36 µM -0.453432334694304 0.328394735321518 no 2264 0.325118728672962 764 3934738 SGTC_1283 0922-0125 16.4 µM -0.453568632184819 0.32834458053182 no 2265 0.325069667396887 722 3360884 SGTC_2017 5132927 60.65 µM -0.454335804241938 0.328062334070276 no 2266 0.324793574818028 749 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis SGTC_2872 9044037 25.97 µM -0.454936161973189 0.327841527886668 no 2267 0.324577583068006 750 6465195 SGTC_1063 disulfiram 1.84 µM -0.455189224167637 0.327748471906725 no 2268 0.324486556108246 730 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_1327 1436-0082 2.18 µM -0.45524339404308 0.327728553960526 no 2269 0.32446707246174 739 15992205 SGTC_2081 5214970 32.255 µM -0.458472580326714 0.32654208827296 no 2270 0.323306478751109 734 2063512 SGTC_2448 5185112 27.17 µM -0.45904205785374 0.326333032623175 no 2271 0.323101982092007 714 5718189 SGTC_1171 0368-0077 21.4 µM -0.459559960413672 0.326142957542107 no 2272 0.322916052165075 733 3239779 SGTC_3244 9134489 49.47 µM -0.459736648117318 0.326078121831326 no 2273 0.322852630408134 773 16584271 SGTC_1941 st076221 61.8 µM -0.460011380305477 0.325977319052499 no 2274 0.322754025979894 703 2828568 SGTC_3084 9116877 49.47 µM -0.46019304349217 0.325910671473371 no 2275 0.322688831891696 761 27241325 SGTC_1539 benzyladenosine 56 µM -0.461460204665558 0.325445937244304 no 2276 0.322234233121454 718 92208 A nucleotide analog. SGTC_2148 5546263 113.568 µM -0.461660352203015 0.325372557470622 no 2277 0.322162453737587 728 792097 SGTC_2861 9024595 19.48 µM -0.462364639367906 0.325114399622312 no 2278 0.321909926312993 722 16482810 SGTC_233 rapamycin 362 pM -0.463794591183856 0.324590506259568 no 2279 0.321397459444351 757 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C SGTC_941 3237-0776 460 µM -0.463902102037911 0.324551131372163 no 2280 0.321358943371435 761 760008 SGTC_705 1124-0212 310 µM -0.463999202652805 0.324515570826998 no 2281 0.321324158447577 773 9554485 SGTC_332 4112-0506 40.9 µM -0.464326813835802 0.324395603658693 no 2282 0.321206807933652 749 2790355 SGTC_1217 1183-1422 255 µM -0.464575318764089 0.324304616377186 no 2283 0.321117805230144 725 2849664 SGTC_1488 4013-0813 75.9 µM -0.464711834539103 0.324254637127048 no 2284 0.321068916113151 725 2910057 SGTC_94 0334-0113 514.748 µM -0.466425901342267 0.323627376632815 no 2285 0.320455337583334 742 6795178 SGTC_1873 rapamycin 2 nM -0.466580572666747 0.323570799471204 no 2286 0.320399994526552 739 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1 SGTC_1440 4100-1550 40 µM -0.466602166351093 0.323562901050474 no 2287 0.320392268392659 753 742806 SGTC_1321 1326-2144 215 µM -0.466981140519381 0.323424294876739 no 2288 0.320256685625245 759 3513030 SGTC_778 3456-2434 196 µM -0.467713801150483 0.323156400746258 no 2289 0.319994635126491 742 5539063 SGTC_1997 st073024 93.8 µM -0.468950171938166 0.32270453518543 no 2290 0.319552626421989 745 686268 SGTC_1543 azetidyl-2-carboxylic acid 198 µM -0.470259517791851 0.32222628418017 no 2291 0.319084808109622 740 16486 A toxic proline analog. SGTC_2957 9076800 11.52 µM -0.471377520032496 0.321818156014014 no 2292 0.318685583158517 759 16459615 SGTC_1750 st081859 2.357 µM -0.471493401393758 0.321775865655124 no 2293 0.318644215363104 757 5291695 SGTC_1902 st060212 70.5 µM -0.47184173466545 0.321648756965179 no 2294 0.318519879557589 726 688944 SGTC_380 3970-0968 6 µM -0.471864268524389 0.32164053495721 no 2295 0.318511836913797 750 2891601 SGTC_865 0488-0499 301 µM -0.473991558502533 0.320864737092916 no 2296 0.317752963447354 759 9634651 SGTC_1125 tnp00248 1.32998 µM -0.474918250782174 0.320527027390127 no 2297 0.31742262118741 735 24207736 SGTC_3299 9121982 43.1275 µM -0.475295801375935 0.320389481136065 no 2298 0.317288075651056 759 17594604 YPL160W CDC60 SGTC_12 0849-0099 9.267 µM -0.476177180168919 0.320068480206371 no 2299 0.316974077741337 771 6071388 SGTC_909 3448-9333 149 µM -0.47738817208887 0.319627652760256 no 2300 0.316542867560077 735 3344074 SGTC_2935 9038016 29.96 µM -0.478380607443674 0.319266574535302 no 2301 0.31618966681901 759 6463195 SGTC_2486 5283202 22.39 µM -0.47908636441117 0.319009902877455 no 2302 0.315938594878139 745 1377751 SGTC_178 4092-0806 87.505 µM -0.480101173199432 0.318640986477724 no 2303 0.315577727026276 740 2169044 SGTC_1734 st037168 69.4 µM -0.480131476666173 0.318629972931324 no 2304 0.315566953759748 751 708907 SGTC_1041 0206-0046 107 µM -0.480287284619066 0.318573348338917 no 2305 0.315511564532599 763 50494 SGTC_3144 9087057 49.47 µM -0.480815142081865 0.3183815429432 no 2306 0.315323943712082 794 17249618 SGTC_3355 9151058 44.0485 µM -0.481984933867627 0.317956654023198 no 2307 0.314908324504039 738 17015728 SGTC_1806 st050005 60.3 µM -0.482575886641278 0.317742100625434 no 2308 0.31469845197044 734 5194765 SGTC_1428 4049-0204 61.7 µM -0.482607081300602 0.317730776681961 no 2309 0.314687375078832 764 X1428 SGTC_2001 4023502 57.655 µM -0.484854418836592 0.316915421960009 no 2310 0.313889808701064 744 108941 YCR052W RSC6 SGTC_1769 st044406 64.4 µM -0.485136860271483 0.316813012369127 no 2311 0.313789633336275 767 670903 SGTC_2635 hydroquinidine 100 µM -0.485311107415521 0.316749839620913 no 2312 0.313727838798932 757 442912 An experimental heart treatment. SGTC_2888 9058547 12.99 µM -0.485584932155101 0.316650576129005 no 2313 0.313630740890024 733 16476514 SGTC_1011 4112-3381 17.4 µM -0.488724585268378 0.315513373641411 no 2314 0.31251834784135 785 2877139 SGTC_2934 9036370 36.88 µM -0.489102743950822 0.315376519682196 no 2315 0.312384479461287 730 6462800 SGTC_1944 st076371 56.9 µM -0.489273661191393 0.315314673795347 no 2316 0.312323982787598 756 24208455 SGTC_1141 3253-0389 52.6 µM -0.48946238964409 0.315246388986937 no 2317 0.312257187658698 775 5402031 SGTC_1939 st074455 53.6 µM -0.489694307409645 0.315162486275193 no 2318 0.312175115336593 781 1644229 SGTC_2484 5809818 12.04 µM -0.490091511631012 0.315018808733631 no 2319 0.312034572196253 748 2870548 SGTC_2244 6635614 200 µM -0.493559830828902 0.313765432045344 no 2320 0.310808537745831 748 836499 SGTC_882 0843-0131 351 µM -0.496737544366257 0.312618957261107 no 2321 0.309687071516401 743 5425421 SGTC_182 3448-4371 550.524 µM -0.498149526842167 0.312110114011556 no 2322 0.309189327273878 715 3491403 SGTC_1677 st019204 53.9 µM -0.499230129906504 0.311720933570133 no 2323 0.308808635439208 741 3945625 SGTC_2374 9071832 200 µM -0.501778176828062 0.310804084229788 no 2324 0.307911782867171 774 17381698 SGTC_1301 naphtanilide LB 4.81 µM -0.501929217981445 0.310749772732228 no 2325 0.307858655869065 771 67238 An a1-adrenergic receptor antagonist or alpha blocker. SGTC_1111 tnp00062 510.699 nM -0.503676386520449 0.310121824455349 no 2326 0.30724440230011 743 676306 SGTC_214 4373-3496 70 µM -0.504082612889481 0.309975902215927 no 2327 0.30710166230633 776 3779166 SGTC_3307 9126885 69.2785 µM -0.50493247732254 0.309670715748128 no 2328 0.30680313113347 752 24824909 SGTC_696 1560-0013 611 µM -0.505157357204048 0.309589983280098 no 2329 0.306724159187058 756 1650269 SGTC_2759 disulfiram 3.38 µM -0.505377035356806 0.309511127116433 no 2330 0.306647022613858 741 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_1417 3966-0327 90.4 µM -0.505850556547032 0.309341180712627 no 2331 0.306480782124926 760 651118 SGTC_3053 9095903 49.47 µM -0.506604045701368 0.309070838088863 no 2332 0.306216334548405 790 17174018 SGTC_748 act1.228 77.9 µM -0.507210674333855 0.308853262311884 no 2333 0.306003503060645 741 4421505 YNR035C ARC35 SGTC_2161 5662504 8.5105 µM -0.507214863394528 0.30885176008021 no 2334 0.306002033585055 731 2859334 SGTC_3192 9110362 49.47 µM -0.509287188268754 0.308108999802962 no 2335 0.305275468428081 769 16649480 SGTC_2611 pyromycin 23.93 µM -0.512132308867565 0.307090534272901 no 2336 0.304279206971994 754 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release. SGTC_1073 triclabendazole 3.09 µM -0.513901569185735 0.306457942614307 no 2337 0.303660405176843 758 50248 An antihelmetic and likely tubulin inhibitor. SGTC_2361 9034121 116 µM -0.514699635229479 0.306172785916505 no 2338 0.30338146418849 778 6496917 SGTC_1820 st053765 18.6 µM -0.515715662225352 0.30580991953687 no 2339 0.30302650700473 766 3690829 SGTC_3256 9138902 49.47 µM -0.515824001935164 0.305771238063788 no 2340 0.302988668623713 789 17228773 SGTC_2225 6654152 15.4 µM -0.516377531817916 0.305573640279155 no 2341 0.302795377552066 777 97582 YGR029W | YLR033W ERV1 | RSC58 SGTC_1234 0326-0494 15.5 µM -0.516548126578625 0.305512753176096 no 2342 0.302735817477334 789 1547813 SGTC_329 k048-0121 21.3 µM -0.517111441041827 0.305311738401534 no 2343 0.302539183706793 762 6832902 SGTC_1981 st071826 47 µM -0.517144734815086 0.305299859591002 no 2344 0.302527563783764 737 11838600 SGTC_1216 1165-0504 9.65 µM -0.517874150146855 0.305039664605525 no 2345 0.302273039375815 768 6304004 SGTC_2827 7993847 71.43 µM -0.518037071174139 0.304981561331539 no 2346 0.302216202345988 760 2985692 SGTC_211 3455-0679 143.504 µM -0.518346050586304 0.304871382089283 no 2347 0.302108424204975 748 748649 SGTC_2921 7974240 10.71 µM -0.518777751564518 0.3047174710825 no 2348 0.301957867256618 772 2979074 YDR527W RBA50 SGTC_92 0063-0024 660.874 µM -0.522096250963219 0.303535507610295 no 2349 0.300801658327453 772 3594437 SGTC_845 0330-0138 4.51 µM -0.523182697836582 0.303148988761026 no 2350 0.300423560364836 780 9039800 SGTC_904 1141-0088 396 µM -0.523683315751873 0.302970960968212 no 2351 0.300249410961805 791 1378119 SGTC_3171 9103192 49.47 µM -0.524462284322107 0.302694040286922 no 2352 0.299978522813894 777 13018434 SGTC_2765 myclobutanil 7.74 µM -0.52548602836607 0.302330275299993 no 2353 0.299622681700678 806 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11 SGTC_1168 k815-0004 80.5 µM -0.525870776789234 0.30219361410744 no 2354 0.299488997240912 760 642433 SGTC_1194 1488-0194 225 µM -0.526510552214578 0.301966429689678 no 2355 0.299266761133494 760 1391452 SGTC_2354 9060492 162 µM -0.527412537260676 0.301646264969608 no 2356 0.298953569531934 780 6471895 SGTC_2769 toremifene 3.73 µM -0.527973914769873 0.301447077940845 no 2357 0.298758720514701 758 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_851 0394-0702 453 µM -0.528188366939165 0.301371002010394 no 2358 0.298684301361347 784 762646 SGTC_273 hydroxyurea 18.1 mM -0.530122535543768 0.300685255403043 no 2359 0.298013487656591 795 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12 SGTC_2803 7707263 71.43 µM -0.530994366435991 0.300376383997537 no 2360 0.297711341523953 761 2199229 SGTC_2544 sphondin 68.51 µM -0.531028233398685 0.300364388535895 no 2361 0.297699607238305 756 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31 SGTC_1460 k062-0059 9.15 µM -0.532060149616109 0.299998994239403 no 2362 0.297342168287963 736 1373085 SGTC_531 3788-1495 174 µM -0.532570258250051 0.299818442665415 no 2363 0.297165547422596 740 2896655 SGTC_620 0109-0052 432 µM -0.533046101804034 0.299650063491063 no 2364 0.297000833805196 788 493037 SGTC_1407 3909-7909 12.3 µM -0.533185866514488 0.29960061532146 no 2365 0.296952462077281 755 4411780 SGTC_1035 k081-0041 55.2 µM -0.533212234811803 0.299591286742837 no 2366 0.296943336571899 783 731709 SGTC_2707 st078556 66.6 µM -0.533329947002887 0.29954964411857 no 2367 0.296902600457744 778 17250899 SGTC_1811 st050069 61.5 µM -0.53397511311411 0.299321452598365 no 2368 0.29667937623189 787 3877702 SGTC_73 0327-0325 16.231 µM -0.534228993631843 0.299231678152321 no 2369 0.296591555928756 755 53298 SGTC_1129 3453-1384 223 µM -0.535544313534689 0.298766764885583 no 2370 0.296136761852707 816 1084452 SGTC_3070 9117005 49.47 µM -0.535558577281984 0.298761725018145 no 2371 0.296131831675384 772 8779016 SGTC_1742 st038235 28.8875 µM -0.535833535972109 0.298664580306604 no 2372 0.296036801241149 794 564103 YBR002C RER2 SGTC_1857 st056007 79.3 µM -0.537965398134046 0.297911867269532 no 2373 0.295300468622355 761 619834 SGTC_2164 5685496 200 µM -0.538628792448381 0.297677814082885 no 2374 0.295071508207354 774 759046 SGTC_2665 lovastatin 100 µM -0.539148704058462 0.297494441922248 no 2375 0.294892125826404 780 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1 SGTC_850 0388-0143 75.9 µM -0.539537151563467 0.297357470656466 no 2376 0.294758134629389 786 67273 SGTC_384 k007-0144 5.16 µM -0.540054190898479 0.297175201071132 no 2377 0.2945798304918 768 6824886 SGTC_2658 polymyxin b sulfate 77.05 µM -0.54084656350104 0.296895968624808 no 2378 0.294306672628439 768 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides.  YIL048W NEO1 SGTC_1157 4092-0394 27.6 µM -0.540877577331652 0.296885041779492 no 2379 0.294295983482472 779 3659885 SGTC_517 1365-0151 113 µM -0.541380505008002 0.296707875143373 no 2380 0.294122670775964 771 768657 SGTC_3184 9108758 49.47 µM -0.541576739945044 0.296638760475867 no 2381 0.294055059517389 776 902885 SGTC_1493 4348-0038 111 µM -0.541783832150763 0.296565829836389 no 2382 0.293983715261703 797 800424 SGTC_1655 st012546 55.1 µM -0.542191226083157 0.296422383906884 no 2383 0.293843389465999 776 720985 YLR208W SEC13 SGTC_680 0417-1641 114 µM -0.542954458157405 0.296153730799707 no 2384 0.293580579567762 760 2835990 SGTC_335 4077-0256 27.6 µM -0.544073518859616 0.295760030260382 no 2385 0.293195441204102 795 3121989 SGTC_2444 5485484 36.41 µM -0.544344505062063 0.295664729863622 no 2386 0.293102213246927 797 6790631 SGTC_1719 st032227 49.2 µM -0.545006431451085 0.295432003029835 no 2387 0.292874547136878 760 3125804 SGTC_3020 9089140 49.47 µM -0.545067294131699 0.295410608538382 no 2388 0.292853617858356 771 17217859 SGTC_2340 7987427 183.45 µM -0.546623921608255 0.29486366417357 no 2389 0.292318565521443 774 2239331 SGTC_2289 7946404 165.07 µM -0.548698720632304 0.294135379044011 no 2390 0.291606112160272 757 1246120 YPR165W RHO1 SGTC_847 0342-0274 5.54 µM -0.550318604927296 0.293567354200505 no 2391 0.291050432760919 766 18097 SGTC_175 3793-3120 23.7 µM -0.551265461521191 0.293235567071643 no 2392 0.290725855643283 819 5322297 SGTC_3295 9122362 53.5725 µM -0.551937338596173 0.293000240747564 no 2393 0.290495642681553 793 4730473 SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM -0.552219790653492 0.292901337501822 no 2394 0.290398888367432 804 7104 SGTC_1135 dihydrocapsaicin 536.708 nM -0.553326186500515 0.292514071886962 no 2395 0.290020036427224 787 107982 A Capsaicinoid. SGTC_476 mead acid 10 µM -0.553617820238577 0.292412032587383 no 2396 0.289920213835436 779 5312531 An omega 9 fatty acid. SGTC_1310 1188-0297 994 nM -0.553796762084872 0.292349431081349 no 2397 0.28985897225022 769 1588352 SGTC_2491 paeonol 100 µM -0.554672764875833 0.292043057835814 no 2398 0.289559254069641 798 11092 Increases levels of cortical cytochrome oxidase. SGTC_2076 5212012 200 µM -0.555449668621505 0.291771468615943 no 2399 0.289293563745539 774 604802 SGTC_1786 berberine 21.6 µM -0.556174222664451 0.291518285860426 no 2400 0.289045879595815 786 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_2575 plumbagin 510 nM -0.557961430003762 0.29089421593772 no 2401 0.288435361076143 794 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_195 4234-0266 16.654 µM -0.559250854644352 0.290444353480634 no 2402 0.287995265293595 776 2303354 SGTC_3141 9094609 49.47 µM -0.561307275316214 0.289727571328214 no 2403 0.287294041389201 787 25236309 YDL196W YDL196W SGTC_1710 st031758 61.5 µM -0.562231027364666 0.289405860455861 no 2404 0.286979312108625 786 5394341 SGTC_2715 st079500 56.4 µM -0.564614219725836 0.288576652936095 no 2405 0.28616809560688 792 28246688 SGTC_821 1114-0266 29.2 µM -0.565629716001427 0.288223661758066 no 2406 0.285822761376518 783 3123235 SGTC_925 2064-1272 59.6 µM -0.568890612096661 0.287091538514043 no 2407 0.284715188356686 783 6815817 SGTC_1161 k007-0610 110 µM -0.568996441432316 0.287054831816691 no 2408 0.28467927745729 796 5843850 SGTC_418 lividomycin a 100 µM -0.569127998755276 0.28700920451642 no 2409 0.284634639335892 769 72394 An antibiotic. SGTC_3274 9138298 49.47 µM -0.571512038922637 0.286182956782412 no 2410 0.283826300985115 791 17015756 SGTC_2382 9035899 200 µM -0.572813609977259 0.285732342615071 no 2411 0.283385451467275 809 6462679 SGTC_159 3970-0959 50 µM -0.575291409102379 0.284875443074806 no 2412 0.282547115321198 781 6615653 SGTC_630 4356-0227 183 µM -0.575338132779549 0.284859296366477 no 2413 0.282531318338301 812 779312 SGTC_3292 9120825 59.784 µM -0.575949317495378 0.284648124158827 no 2414 0.282324719726385 806 24824900 SGTC_1370 2001-0092 44.6 µM -0.577971011411897 0.283950135824336 no 2415 0.281641845394026 801 790957 SGTC_782 0083-0095 30.5 µM -0.578579307730976 0.283740282374874 no 2416 0.281436535091286 797 3591729 An indicator and reagent. SGTC_1226 3909-7979 35.4 µM -0.579213247410018 0.283521661399099 no 2417 0.281222646599668 794 6615510 SGTC_2573 2',4'-dihydroxychalcone 15.04 µM -0.579564797999736 0.283400460168907 no 2418 0.281104068801512 769 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_2347 9049783 174.81 µM -0.579742958851784 0.283339046589968 no 2419 0.28104398447833 820 6467988 YPL169C MEX67 SGTC_99 0109-0120 622.8 µM -0.579860243349034 0.283298621098014 no 2420 0.281004433948058 798 759414 SGTC_117 lucigenin 22.078 µM -0.579903008695571 0.283283881473446 no 2421 0.280990013340977 809 65100 An acridine derivative; a dye stuff and potential carcinogen. SGTC_266 formosanin C 406 nM -0.58203409713417 0.282549840764791 no 2422 0.280271857033408 786 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1 SGTC_2320 7373003 200 µM -0.582848609602888 0.282269528540338 no 2423 0.279997609194304 791 5415828 SGTC_1965 Pectolinarigenin 58.4 µM -0.583347179668233 0.282098013076359 no 2424 0.279829803955433 793 5320438 An anti-inflammatory. SGTC_2867 9039098 71.43 µM -0.583655950417106 0.281991816546999 no 2425 0.27972590451479 777 6463460 SGTC_2846 9008642 19.48 µM -0.585360858488624 0.281405788907908 no 2426 0.279152550804972 835 2992898 SGTC_3296 9122258 64.045 µM -0.585983482657382 0.281191921055512 no 2427 0.278943307317263 792 4730474 SGTC_2477 5967686 25.23 µM -0.586470967240099 0.28102452768586 no 2428 0.27877953306886 773 776118 SGTC_2700 st077718 96.8 µM -0.587378553621383 0.280713007301331 no 2429 0.278474747079927 781 904970 SGTC_584 0986-0246 15.4 µM -0.587437738709904 0.280692698385726 no 2430 0.278454877161948 816 53315 YDR232W HEM1 SGTC_1066 ketoconazole 628 nM -0.587606288410425 0.280634865724771 no 2431 0.278398294587113 809 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W SGTC_1692 fluoroquinolonic acid 71 µM -0.588351645946939 0.280379188279334 no 2432 0.278148143311637 797 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2 SGTC_126 0417-1624 672.48 µM -0.590050917901335 0.279796714872589 no 2433 0.277578256657232 815 41912 YDL195W SEC31 SGTC_1916 st067606 49.2 µM -0.590702119587767 0.279573652812127 no 2434 0.277360013761582 774 19590279 SGTC_1406 3909-7906 11.9 µM -0.591961899017187 0.279142374273407 no 2435 0.276938051205775 791 X1406 SGTC_2210 7115885 190.385 µM -0.594776092966515 0.278180120396756 no 2436 0.275996575043788 807 2927039 SGTC_488 nitrendipine 139 µM -0.59541398063545 0.277962233351606 no 2437 0.275783391265029 795 4507 Dihydropyridine L-type calcium channel blocker. SGTC_618 k072-0232 33.2 µM -0.598358601787402 0.276957502750755 no 2438 0.274800341191238 799 5872756 YGL099W LSG1 SGTC_3215 9129942 49.47 µM -0.599753329914894 0.276482230593127 no 2439 0.274335320373323 816 17682944 SGTC_3281 9140613 49.47 µM -0.600459857779885 0.27624162452472 no 2440 0.27409990296746 774 16013766 SGTC_1763 st044482 94.5 µM -0.602709527656451 0.275476190937072 no 2441 0.273350971093124 806 88505 SGTC_2638 epoxomicin 18 µM -0.602756479038806 0.275460227196349 no 2442 0.273335351429981 792 9915668 A protesome inhibitor. SGTC_1253 0550-0034 176 µM -0.604272887373132 0.27494488446103 no 2443 0.272831114478604 791 5969915 SGTC_2459 5811157 9.22 µM -0.604498662279417 0.274868196795454 no 2444 0.272756079161599 798 2870684 YBR192W RIM2 SGTC_3066 9117245 49.47 µM -0.605790870606652 0.274429482758729 no 2445 0.272326816393764 800 17176980 SGTC_3121 9125696 49.47 µM -0.605843104573694 0.274411756220336 no 2446 0.272309471687447 828 1235365 SGTC_2993 9054257 71.4286 µM -0.6059599266632 0.274372112583733 no 2447 0.272270681965312 804 6470217 YGL055W OLE1 SGTC_967 1306-0166 352 µM -0.607010087949271 0.274015866796207 no 2448 0.271922108698507 810 4437607 SGTC_1051 3253-3903 78 µM -0.608500164710018 0.273510781256201 no 2449 0.27142789837802 809 5509239 SGTC_1644 st010134 20.9 µM -0.608891979457687 0.273378045889999 no 2450 0.271298020429191 816 3818134 SGTC_3085 9117376 49.47 µM -0.609573690615434 0.273147178162837 no 2451 0.271072122066221 794 16480349 SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM -0.615025261888977 0.271304436567597 no 2452 0.269269018754246 820 279621 SGTC_1107 amlodipine 47 µM -0.615214604146005 0.271240546553712 no 2453 0.269206502195536 782 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.  SGTC_1504 k297-0033 30 µM -0.616115244158926 0.270936745100876 no 2454 0.26890923082342 766 4388117 SGTC_1697 st025554 27.742 µM -0.616628750980676 0.270763606399617 no 2455 0.268739813074086 801 1269519 SGTC_3041 9091929 49.47 µM -0.61864270462217 0.270085096777487 no 2456 0.268075881249078 808 25236887 SGTC_722 3534-0461 190 µM -0.619926457388297 0.269653039323928 no 2457 0.267653103069099 793 658262 SGTC_950 1165-0508 94.1 µM -0.62068226261151 0.269398828948282 no 2458 0.267404351072044 801 6148369 SGTC_2510 benzyl isothiocyanate 8.31 µM -0.621997239406952 0.268956831252677 no 2459 0.266971841621166 820 2346 DNA damaging agent; causes G2/M arrest. SGTC_3323 9138564 53.9225 µM -0.622617573520819 0.268748447373235 no 2460 0.266767930049198 793 43912313 YNL103W MET4 SGTC_3097 9117246 49.47 µM -0.623351585345783 0.268501981454052 no 2461 0.2665267529057 801 16423892 SGTC_51 1013-0126 23.419 µM -0.623472448863068 0.268461408894772 no 2462 0.266487050882543 806 1627850 SGTC_2667 digitoxin 100 µM -0.625221838726829 0.267874503286672 no 2463 0.265912735284355 789 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_796 1234-0020 70.7 µM -0.625261936191816 0.267861058504066 no 2464 0.265899578850929 793 46495034 SGTC_478 N-arachidonylglycine 10 µM -0.625796911733888 0.267681712362037 no 2465 0.265724078865565 770 5283389 SGTC_1162 k048-0130 20.1 µM -0.626059974714166 0.267593544867085 no 2466 0.265637801979548 809 6797406 SGTC_2797 7859098 81.82 µM -0.626409541638658 0.267476407594791 no 2467 0.26552317634032 798 972681 SGTC_2288 7946289 167.31 µM -0.626746154743139 0.267363635495126 no 2468 0.265412822075848 812 1246052 SGTC_1272 0839-0021 27 µM -0.627142923073509 0.267230741001277 no 2469 0.265282776588097 819 5027250 SGTC_2369 9071472 200 µM -0.627249297835774 0.267195117262426 no 2470 0.265247916507991 808 17296037 SGTC_3336 9143619 71.43 µM -0.630075426572618 0.266249556422754 no 2471 0.264322618182696 810 45595730 SGTC_160 3453-0671 289.699 µM -0.630179877537303 0.266214641899734 no 2472 0.26428845157577 832 5322268 SGTC_2348 9022543 33.42 µM -0.630197029334781 0.266208908839368 no 2473 0.26428284132342 812 3162678 YDL140C RPO21 SGTC_3060 1327-0027 12.5 µM -0.631191473842469 0.265876618485961 no 2474 0.26395766807251 796 16000455 YPR107C YTH1 SGTC_361 000s-0510 1.45 µM -0.631223762801961 0.265865832760779 no 2475 0.263947113329868 802 660 SGTC_295 k015-0027 31 µM -0.631685324274835 0.265711678136323 no 2476 0.263796259811556 807 3887424 SGTC_2695 st077686 51.995 µM -0.632274280969068 0.265515041240987 no 2477 0.263603833192878 795 2876092 SGTC_939 1165-0479 45.3 µM -0.632621367692788 0.26539919284461 no 2478 0.263490464983487 813 1377347 SGTC_2899 9053889 58.44 µM -0.63286870644946 0.265316653345184 no 2479 0.26340969243141 794 6470052 SGTC_1165 k072-0275 30.3 µM -0.634539941489165 0.264759286621704 no 2480 0.26286425451473 810 6153523 YGL055W OLE1 SGTC_2969 9091408 28.7 µM -0.634553604985613 0.26475473222001 no 2481 0.262859797565749 797 4286311 SGTC_3088 9117578 49.47 µM -0.636848977247417 0.263990190334143 no 2482 0.262111610088101 824 678341 SGTC_2767 sibutramine 71.45 µM -0.637140833380768 0.263893059672346 no 2483 0.262016556463974 816 64765 A serotonin-norepinephrine reuptake inhibitor.  SGTC_3335 9143315 29.6265 µM -0.638106836493111 0.263571700716844 no 2484 0.26170206830586 794 4899691 SGTC_1917 st066507 28.5 µM -0.639188431576415 0.263212125045123 no 2485 0.261350178457011 795 3156428 SGTC_2186 6124449 200 µM -0.639313794628772 0.263170464380295 no 2486 0.261309408134794 808 3834182 YLR033W RSC58 SGTC_3350 9150499 3.57 µM -0.639566529604867 0.263086485704987 no 2487 0.261227224103299 825 4910996 YPR165W RHO1 SGTC_976 1348-1067 47.6 µM -0.64028819292736 0.26284676710879 no 2488 0.260992627687558 821 5310671 YGL099W LSG1 SGTC_2691 st077356 60.2 µM -0.640951639445213 0.262626485272578 no 2489 0.260777051850035 825 2839272 SGTC_2360 9040895 200 µM -0.642184782528747 0.262217300187025 no 2490 0.260376606186267 800 4914414 SGTC_2780 5215298 71.43 µM -0.642877219316647 0.261987677100847 no 2491 0.260151886145462 824 2834131 SGTC_2120 5538279 151.968 µM -0.643125483347293 0.261905373901136 no 2492 0.260071340107918 799 2058197 SGTC_2176 5809774 33.9695 µM -0.644654524492743 0.261398766595771 no 2493 0.259575546187777 792 2870539 SGTC_2040 5100729 123 µM -0.645136967001808 0.261239026551565 no 2494 0.259419214811507 816 11840 YJR013W | YDR381W GPI14 | YRA1 SGTC_565 1418-0001 44.5 µM -0.647785807975741 0.260362871579167 no 2495 0.25856174790196 834 2862145 SGTC_3276 9139060 49.47 µM -0.650465782013056 0.259477961783618 no 2496 0.257695698865837 835 4870619 SGTC_2074 5212007 75.395 µM -0.651163041758341 0.259247986108985 no 2497 0.257470622497621 804 758611 SGTC_1001 4048-4355 44.4 µM -0.651399495654864 0.259170020957239 no 2498 0.25739431806218 813 21824233 SGTC_2558 carylophyllene oxide 100 µM -0.65154635746858 0.259121602805658 no 2499 0.257346931197153 835 6708694 An oxygenated terpenoid and antifungal agent. SGTC_2726 cimetidine 79.27 µM -0.652485050917678 0.258812240073214 no 2500 0.257044156738621 828 2756 A P450 inhibitor, histamine H2-receptor antagonist. SGTC_3106 9121286 49.47 µM -0.653027253106125 0.25863363504533 no 2501 0.256869354523394 796 15943471 SGTC_1561 5-methoxyflavone 52.9 µM -0.654762545318619 0.258062447419839 no 2502 0.256310324474885 807 94525 SGTC_16 erodoxin 22.806 µM -0.656710092007155 0.257422174251782 no 2503 0.255683672032901 827 3967339 Erodoxin inhibits Ero1. YML130C ERO1 SGTC_431 k089-0097 107 µM -0.657212912043222 0.257257001883261 no 2504 0.255522012159992 820 5499420 SGTC_3079 9117512 49.47 µM -0.657240020861046 0.257248098418369 no 2505 0.255513298018119 866 7185044 SGTC_1267 0828-0272 9.49 µM -0.658604173137848 0.256800270980774 no 2506 0.255074991204872 819 745334 SGTC_3023 9089636 49.47 µM -0.658839735254834 0.256722981145223 no 2507 0.25499934412764 822 17249241 SGTC_723 4182-0001 115 µM -0.660312744616815 0.256239949642965 no 2508 0.254526576601431 824 744821 YLR208W SEC13 SGTC_428 3448-4153 16.5 µM -0.663224963683779 0.255286366510915 no 2509 0.253593242812588 806 3834874 SGTC_2146 5545642 200 µM -0.665216784637478 0.254635230416644 no 2510 0.252955923222521 815 825326 SGTC_1805 st050013 60.3 µM -0.666212528714565 0.254310043181474 no 2511 0.252637632968304 821 4037144 SGTC_1298 1079-1278 263 µM -0.666352118847018 0.25426447364287 no 2512 0.252593029755061 824 2840950 SGTC_1497 4476-2978 41.3 µM -0.669224513758163 0.253327724588671 no 2513 0.2516761355607 816 1528379 SGTC_3190 9110366 49.47 µM -0.669296115381354 0.253304396974711 no 2514 0.251653302157274 804 17123768 SGTC_2733 amorolfine 100 µM -0.670099170658199 0.253042841132299 no 2515 0.251397286773656 846 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_854 0422-0053 192 µM -0.670342474659626 0.252963624850873 no 2516 0.251319748227225 834 3596728 SGTC_3231 9132313 49.47 µM -0.671042528974432 0.252735770054562 no 2517 0.251096718478665 820 4905967 SGTC_2809 7964133 12.99 µM -0.672092578649794 0.252394200942952 no 2518 0.250762380396256 837 1253665 SGTC_2425 5628681 7.85 µM -0.672330071243838 0.252316981079648 no 2519 0.250686794941079 840 5714958 SGTC_1991 st073000 8.92 µM -0.673142249318649 0.252052998456161 no 2520 0.250428398731976 838 4301969 YIL048W NEO1 SGTC_2645 abamectin 100 µM -0.674098226340207 0.251742463588807 no 2521 0.250124433535273 811 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels. SGTC_2464 5717415 7.67 µM -0.67409954540206 0.251742035250865 no 2522 0.250124014257829 810 5285744 SGTC_604 1000-0114 314 µM -0.67433160250246 0.25166668551665 no 2523 0.250050258312302 834 1572745 SGTC_208 k072-0098 12.366 µM -0.67473173293093 0.251536789780312 no 2524 0.249923109831602 834 5948901 SGTC_1410 3909-8106 77.9 µM -0.67511936445069 0.251410985397265 no 2525 0.249799965830373 838 1039210 SGTC_3007 9078383 71.4286 µM -0.675944203615757 0.251143397594659 no 2526 0.249538035573899 816 6496995 SGTC_93 0109-0045 59.227 µM -0.676214962358849 0.251055593035823 no 2527 0.249452087111572 834 88733 SGTC_2585 alliin 100 µM -0.680313362858066 0.249728505592428 no 2528 0.248153032566043 841 87310 A garlic compound which reacts with lipids. SGTC_1616 st002734 56.1 µM -0.681163897182663 0.249453564822901 no 2529 0.247883894722312 818 4026101 SGTC_1836 st055642 81 µM -0.681779958489401 0.249254519489724 no 2530 0.247689049415251 842 8571 SGTC_1109 tnp00067 928.257 nM -0.684736185653407 0.248300558171114 no 2531 0.246755205225713 829 676295 SGTC_2774 tamoxifen 10.92 µM -0.687033964107148 0.247560421964298 no 2532 0.246030662865835 838 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  SGTC_2105 5350118 200 µM -0.688265387863284 0.247164254324372 no 2533 0.245642836899234 834 2133313 SGTC_2470 5664817 21.68 µM -0.68867767711748 0.247031690442148 no 2534 0.245513063465332 834 2859561 SGTC_106 0092-0003 11.579 µM -0.688741932520105 0.247011033748449 no 2535 0.245492841555194 820 1072148 SGTC_2084 5306078 60.6385 µM -0.68875301174067 0.247007472116994 no 2536 0.245489354888216 858 679340 SGTC_2275 7947463 200 µM -0.689407684043411 0.246797063732247 no 2537 0.245283374614864 828 1225414 SGTC_3072 9116419 49.47 µM -0.695089657560969 0.244974943249676 no 2538 0.243499557922838 824 17170162 SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM -0.695516821039508 0.244838251701523 no 2539 0.243365736672163 850 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis. SGTC_1398 3558-0053 112 µM -0.696502235758161 0.244523077401105 no 2540 0.243057178805246 817 4532369 SGTC_1078 idebenone 36.1 µM -0.697710916732099 0.24413679242678 no 2541 0.242678999821323 848 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen. SGTC_237 nikkomycin 200 µM -0.698076767726996 0.244019934224315 no 2542 0.242564593116117 845 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine. SGTC_1632 st005650 90 µM -0.698609010112663 0.243849982050013 no 2543 0.242398205673045 833 2759605 SGTC_2070 5230947 200 µM -0.699782048149314 0.243475640825833 no 2544 0.24203171373701 859 2835538 SGTC_1929 genistein trimethyl ether 50.5 µM -0.699834882338773 0.243458787628847 no 2545 0.242015213841775 823 136420 SGTC_131 0141-0277 33.849 µM -0.700342432164516 0.243296920083121 no 2546 0.241856739249048 848 1547771 SGTC_819 1013-0258 27.7 µM -0.700399852111154 0.243278611404614 no 2547 0.241838814303589 831 5753198 SGTC_2405 ticlatone 3.52 µM -0.700897684267707 0.24311990599522 no 2548 0.24168343486777 831 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W SGTC_770 0389-1121 67.2 µM -0.701227146613453 0.243014906496713 no 2549 0.241580635492097 839 6753108 SGTC_1465 k213-0056 144 µM -0.701245327554714 0.243009112953282 no 2550 0.241574963336628 836 24048857 YMR208W ERG12 SGTC_1568 digitonin 820 nM -0.70141458055659 0.242955182333285 no 2551 0.241522162646463 857 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1 SGTC_1252 0493-0875 34.8 µM -0.701741749113128 0.242850952004376 no 2552 0.241420115900163 821 3960963 SGTC_1643 st009866 20.2 µM -0.702258759123107 0.242686290766041 no 2553 0.241258903698689 818 3156273 YOR207C RET1 SGTC_1305 1181-0477 144 µM -0.707592219881557 0.240991183233077 no 2554 0.239599262849343 848 6252086 SGTC_2674 ligustilide 100 µM -0.708561997225548 0.240683657000255 no 2555 0.239298163174889 831 5319022 A signalling regulator. SGTC_1703 st026983 48.3 µM -0.708906765876159 0.240574378852088 no 2556 0.239191168093328 827 1104023 SGTC_2255 7941087 197.44 µM -0.709462125289674 0.240398408503861 no 2557 0.239018873516555 826 935561 SGTC_1484 3473-2379 286 µM -0.712463854618095 0.239448499786773 no 2558 0.238088793204964 851 671917 SGTC_1479 0549-0158 134 µM -0.712691481629642 0.239376550053027 no 2559 0.238018344393026 840 5440202 SGTC_729 4092-0585 94.1 µM -0.715246202189868 0.238569848916447 no 2560 0.237228462282811 835 2169061 SGTC_1780 st038448 24.544 µM -0.715281794880289 0.238558620373901 no 2561 0.237217467724357 851 728868 YDL195W SEC31 SGTC_2694 st077685 81.9 µM -0.715471688534449 0.238498718890211 no 2562 0.237158814431055 823 2838096 SGTC_379 3970-0972 5.9 µM -0.715861693533322 0.238375718604263 no 2563 0.237038376850619 849 2898042 YBL034C STU1 SGTC_2750 bromebric acid 70.15 µM -0.716409913097962 0.23820287915391 no 2564 0.236869137821622 842 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2 SGTC_265 mycophenolic acid 32.932 µM -0.716480825683311 0.238180527265889 no 2565 0.23684725148794 850 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1 SGTC_2022 5136654 200 µM -0.718127385680839 0.237661849223946 no 2566 0.236339372928628 846 1713771 SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM -0.719117550071727 0.237350239075469 no 2567 0.236034247387518 842 1377 SGTC_1560 lithocholic acid 53.1 µM -0.719233177228195 0.23731386521166 no 2568 0.235998630292815 833 9903 A bile acid which acts as a detergent. SGTC_277 nystatin 15.5 µM -0.721442463116104 0.23661945884222 no 2569 0.235318664361426 857 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_600 1495-0418 41.6 µM -0.72218715336482 0.236385645479383 no 2570 0.235089710270898 856 5377768 SGTC_544 k015-0020 52.4 µM -0.723024067828621 0.236123027973852 no 2571 0.234832548874303 848 3008304 SGTC_768 0384-0033 77.3 µM -0.723479763813492 0.235980101589035 no 2572 0.234692591111458 837 3965305 YMR134W ERG29 SGTC_802 4112-3352 742 µM -0.724200344143353 0.235754193109436 no 2573 0.234471373663392 818 704594 SGTC_374 0880-0231 82.3 µM -0.724280000895224 0.235729227316167 no 2574 0.234446926202662 847 6833587 SGTC_2170 morpholine 200 µM -0.724831348103283 0.23555646561244 no 2575 0.234277750852756 837 121171 Reacts with secondary amines. SGTC_2787 5284540 71.43 µM -0.726165915099091 0.235138575493049 no 2576 0.233868532259983 845 736958 SGTC_2299 7976368 114.88 µM -0.727502852418152 0.234720354027944 no 2577 0.233458984299856 843 2979718 SGTC_1935 st074532 41.6 µM -0.728838392654865 0.23430298055686 no 2578 0.233050261831274 847 2829742 SGTC_562 3772-2733 112 µM -0.72889716579078 0.234284622638564 no 2579 0.233032284308816 831 2876874 YIL048W NEO1 SGTC_1289 0976-0073 69.1 µM -0.730092797861668 0.233911337223694 no 2580 0.232666731691439 850 3391136 SGTC_2171 5739187 198.077 µM -0.730338974057466 0.23383452007511 no 2581 0.232591505356509 835 2262761 SGTC_1020 4335-0961 93.3 µM -0.730342468367207 0.233833429806672 no 2582 0.232590437665331 875 669075 SGTC_860 0443-0016 25.1 µM -0.730756023135359 0.233704415433359 no 2583 0.232464094679421 851 5337942 SGTC_3128 9127691 49.47 µM -0.731166320425056 0.233576456281967 no 2584 0.232338784595113 845 41316314 SGTC_2951 9072950 58.06 µM -0.731332392746389 0.233524674461517 no 2585 0.232288074651408 855 16488155 SGTC_483 fpl-64176 144 µM -0.731406310562619 0.23350162872463 no 2586 0.232265505933435 859 3423 SGTC_2540 epiandrosterone 100 µM -0.732165668752906 0.233264952780735 no 2587 0.232033728011927 862 441302 A steroid. SGTC_2766 oltipraz 83.91 µM -0.732736802222535 0.233087030276577 no 2588 0.231859486561438 833 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40 SGTC_1726 st035556 14.5795 µM -0.732754302719496 0.233081579619747 no 2589 0.231854148659273 842 5919439 SGTC_2206 7254556 146.969 µM -0.733206751708189 0.232940685667233 no 2590 0.231716169002332 838 4398905 SGTC_459 nigericin 15.3 µM -0.733485197422418 0.232854000369226 no 2591 0.231631276445089 862 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification. SGTC_2196 6573537 42.6665 µM -0.735893566938774 0.232104978775124 no 2592 0.230897736275965 866 2903087 SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM -0.736189197562815 0.232013127867679 no 2593 0.230807782693199 846 676296 Flavone; oxidizing agent. SGTC_1785 bathophenanthroline 24 µM -0.737814682067764 0.231508459947254 no 2594 0.230313535049767 829 72812 An iron chelator. SGTC_2838 9002687 71.43 µM -0.738768954484996 0.231212470122885 no 2595 0.230023653257095 859 6457060 SGTC_736 0958-0254 92.6 µM -0.738863977918952 0.231183007953985 no 2596 0.22999479892573 852 6812352 SGTC_3148 9097893 49.47 µM -0.740620428461695 0.230638794994595 no 2597 0.229461809033746 816 17174100 SGTC_622 1348-1566 26.3 µM -0.742258966745709 0.230131761571168 no 2598 0.228965223949446 850 7340407 SGTC_1871 st057448 67.3 µM -0.743369099514723 0.229788593962571 no 2599 0.228629123524609 863 691747 SGTC_38 0929-0051 58.268 µM -0.743511243392488 0.229744674718672 no 2600 0.228586108494567 857 1379719 SGTC_1881 5652484 16 µM -0.744281599447242 0.229506733909067 no 2601 0.22835306541447 852 2255129 SGTC_2919 7978188 46.38 µM -0.744788628954988 0.229350202471111 no 2602 0.228199755049417 829 2980291 SGTC_2981 9013952 38.96 µM -0.744829616380473 0.229337551343974 no 2603 0.228187364221977 822 2996344 SGTC_3029 9088683 49.47 µM -0.746073374098429 0.228953840750756 no 2604 0.227811546228563 823 25236615 SGTC_3242 9133940 49.47 µM -0.746201134565946 0.228914445895233 no 2605 0.227772961435815 854 17248444 SGTC_3254 9136651 49.47 µM -0.746877596330186 0.228705922762366 no 2606 0.227568725296041 887 16454030 SGTC_2600 tangeritin 87.95 µM -0.747215317233315 0.228601858327406 no 2607 0.227466799803162 865 68077 A bioactive flavone. SGTC_1426 4048-4480 71.7 µM -0.747253541709405 0.228590081612967 no 2608 0.22745526512643 852 14224343 SGTC_3245 9134821 49.47 µM -0.747353533878695 0.228559276282427 no 2609 0.227425092893754 864 17014901 SGTC_2552 juarezic acid 87.02 µM -0.748654801509978 0.228158597784885 no 2610 0.227032646289595 849 1549512 SGTC_1764 st044502 93.5 µM -0.749450563936449 0.227913766142714 no 2611 0.226792842228797 855 8407 SGTC_1839 st053978 48 µM -0.750406746177512 0.227619773861326 no 2612 0.226504884561754 863 3788398 SGTC_2087 5276107 200 µM -0.751927916995155 0.227152507867673 no 2613 0.226047204293143 849 144405 SGTC_836 0330-0104 1.35 µM -0.752044761534091 0.227116638494713 no 2614 0.226012070477914 835 46494820 SGTC_1331 1472-0049 76.2 µM -0.753679078107006 0.226615264686929 no 2615 0.225520973862509 858 24051409 SGTC_1781 st038725 66.3 µM -0.75421348190627 0.22645145652876 no 2616 0.225360521723835 868 4270275 YIL048W NEO1 SGTC_1974 st069448 26.9 µM -0.755614596127818 0.226022297514261 no 2617 0.224940151041064 834 6323587 YNR016C ACC1 SGTC_2627 acetyl isogambogic acid 100 µM -0.755750724658517 0.225980626084434 no 2618 0.224899332645848 865 6857789 A caspase activator and apoptosis inducer. SGTC_516 3992-2719 87.3 µM -0.755939554955072 0.225922828873381 no 2619 0.224842718479747 866 5350887 YDR037W KRS1 SGTC_1470 k295-0292 231 µM -0.756878326094919 0.225635613734183 no 2620 0.224561380722561 863 5045612 SGTC_2101 5377231 179.231 µM -0.758591110177606 0.225112123614676 no 2621 0.224048596105468 863 2844213 SGTC_3333 9141820 12.094 µM -0.759021693612497 0.224980629723087 no 2622 0.223919789898906 849 1939433 SGTC_2447 5741742 33.78 µM -0.760188712484432 0.224624458173729 no 2623 0.223570895528073 862 1776504 SGTC_235 0330-0087 5 mM -0.760214696479156 0.224616531558465 no 2624 0.223563130819602 859 46494818 YHR062C RPP1 SGTC_3170 9103054 49.47 µM -0.761781766151494 0.224138778472288 no 2625 0.223095132374579 861 16432970 SGTC_2735 sertaconazole 140 nM -0.761814232645048 0.224128886506986 no 2626 0.223085442301566 890 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C SGTC_828 2074-0507 139 µM -0.763173844467264 0.22371485954367 no 2627 0.222679862615125 850 X828 SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM -0.768836422762335 0.221995183919977 no 2628 0.220995211818456 866 115019 SGTC_1651 st011928 86.1 µM -0.769933504619525 0.22166288466674 no 2629 0.220669669028626 873 720198 SGTC_3319 9138450 16.7555 µM -0.770250002471003 0.221567072294132 no 2630 0.220575804058281 853 2029690 SGTC_2591 skatole 100 µM -0.770377398494678 0.221528512789692 no 2631 0.22053802819356 871 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite. SGTC_3227 9130768 49.47 µM -0.77106292215221 0.221321088250712 no 2632 0.220334818242585 877 17720899 SGTC_535 2293-4129 48.2 µM -0.771515149026506 0.221184315067374 no 2633 0.220200823299198 898 396118 YIL048W NEO1 SGTC_3055 9094636 49.47 µM -0.772160107476172 0.22098933511106 no 2634 0.220009802810456 866 25236176 SGTC_2653 dihydrofissinolide 100 µM -0.772758589716614 0.220808493594325 no 2635 0.219832632479917 871 6857746 SGTC_1705 st027868 56.3335 µM -0.772882480687074 0.220771068434603 no 2636 0.219795966931276 854 292948 SGTC_3308 9128332 17.569 µM -0.77383707553736 0.220482824923555 no 2637 0.219513572217008 833 17332805 YDL196W YDL196W SGTC_2556 citropten 84.59 µM -0.773909277510925 0.220461032042208 no 2638 0.21949222142148 828 2775 A potential DNA crosslinker. SGTC_659 k018-0002 107 µM -0.773942429571613 0.220451026095975 no 2639 0.219482418448248 884 6797879 YHR007C ERG11 SGTC_2778 tioconazole 65.09 nM -0.774884414880156 0.220166825121855 no 2640 0.219203981104592 865 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_2483 5729050 27.16 µM -0.775914346049581 0.219856331113328 no 2641 0.218899780732579 863 2865180 SGTC_2387 9077560 195.08 µM -0.776712795202291 0.219615795172631 no 2642 0.218664118075473 871 5303272 SGTC_1056 3448-1962 115 µM -0.777359741261555 0.219421011017099 no 2643 0.218473278778019 874 715507 SGTC_2816 7982706 58.44 µM -0.777414423642721 0.21940455165824 no 2644 0.218457152700442 869 2981853 SGTC_1003 4049-0218 100 µM -0.778710452189763 0.219014655672986 no 2645 0.218075148820971 865 295161 SGTC_1163 k060-0048 49.9 µM -0.779223527145325 0.218860412866004 no 2646 0.217924026644752 855 6809982 SGTC_3009 9080819 71.4286 µM -0.779640491273769 0.21873510935638 no 2647 0.217801257646005 868 17027216 SGTC_953 1188-0045 9.7 µM -0.779862816343999 0.218668314465702 no 2648 0.217735813585715 864 6144426 SGTC_2113 5491891 107.031 µM -0.780259442506989 0.218549182070562 no 2649 0.21761909007714 859 789979 SGTC_2232 chlorophetanol 41.5365 µM -0.780667846056313 0.218426551227524 no 2650 0.217498938331476 859 15907 An antifungal of unknown mechanism. YFR051C RET2 SGTC_1610 st001799 48.1 µM -0.780939900059551 0.218344883896163 no 2651 0.217418921683766 871 621897 SGTC_915 methyl methanesulfonate (MMS) 110 mM -0.781832186653011 0.218077153705299 no 2652 0.21715660125853 861 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks. SGTC_2669 eugenol 100 µM -0.781973477672345 0.218034776759984 no 2653 0.217115080347639 841 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism. SGTC_1132 3456-3614 2.5 µM -0.781974112596589 0.218034586339983 no 2654 0.217114893774067 881 3125502 SGTC_2242 6630449 61.2675 µM -0.782152221108126 0.217981173638162 no 2655 0.217062559941939 874 691249 YDR170C SEC7 SGTC_2051 5263410 176 µM -0.784106619272504 0.21739556780499 no 2656 0.216488775871533 858 227584 SGTC_660 4031-1742 102 µM -0.784792515430325 0.217190264930878 no 2657 0.216287614558171 850 6738706 SGTC_1275 0867-0008 21.1 µM -0.786744556694843 0.216606592018235 no 2658 0.215715707657949 867 3422836 SGTC_3038 9091290 49.47 µM -0.78792300066772 0.216254669354738 no 2659 0.215370873229094 865 25236843 SGTC_2583 asiatic acid 100 µM -0.789755696380314 0.215708023558697 no 2660 0.214835228627743 891 5320556 A kinase inhibitor; arrests cells at G2/M. SGTC_2943 9068529 45.32 µM -0.789977080157601 0.215642044766627 no 2661 0.214770576904835 881 3270634 SGTC_3052 9092717 49.47 µM -0.793801084227864 0.214504228538814 no 2662 0.213655620684438 872 25237534 SGTC_1114 scopoletin 1.73284 µM -0.795420407501244 0.214023459696935 no 2663 0.213184496407763 876 5280460 A coumarin with genotoxic properties. SGTC_683 panaxydol 45 µM -0.796294830818737 0.213764108858946 no 2664 0.21293034469489 844 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis. SGTC_2683 piperine 63.03 µM -0.79650421152643 0.213702034460479 no 2665 0.212869514303024 878 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_2830 7992007 71.43 µM -0.802165934650869 0.212027506859761 no 2666 0.211228489396172 871 1952075 SGTC_3189 9110682 49.47 µM -0.802280082136596 0.211993825373115 no 2667 0.211195480670669 875 17122418 SGTC_615 k087-0205 167 µM -0.802567953896622 0.211908896981493 no 2668 0.211112248460322 872 9642773 SGTC_3122 9126309 49.47 µM -0.802664994746733 0.211880272319258 no 2669 0.211084195423541 895 17591206 SGTC_2546 rhodinyl acetate 100 µM -0.804546755707788 0.211325646526154 no 2670 0.210540639002353 870 6708682 SGTC_2357 9067248 200 µM -0.805391045885244 0.211077079067971 no 2671 0.210297028599792 898 9150235 SGTC_1883 5-benzylidenerhodanine 20 µM -0.806498726560013 0.210751226850462 no 2672 0.209977670994331 847 1273210 SGTC_3062 9077494 49.47 µM -0.807507157455625 0.210454828213958 no 2673 0.209687176271327 801 16459633 SGTC_3207 9114163 49.47 µM -0.808699969485969 0.210104552232407 no 2674 0.209343872869098 889 849233 SGTC_2737 bleomycin 30.5 nM -0.809227927704206 0.209949623730341 no 2675 0.209192026804289 868 16211318 Bleomycin acts by induction of DNA strand breaks. SGTC_800 3448-7362 155 µM -0.810057064120033 0.209706450520725 no 2676 0.208953689797357 882 15991913 SGTC_144 4161-2749 112.381 µM -0.810974544038219 0.209437560612731 no 2677 0.208690144775958 867 797501 YMR168C CEP3 SGTC_2596 sinensetin 100 µM -0.811679788212158 0.209231009540829 no 2678 0.208487697464304 890 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets. SGTC_248 streptozotocin 5.23457 mM -0.813096107093268 0.20881656216266 no 2679 0.20808147912481 880 5300 DNA alkylating agent. SGTC_141 0443-0274 32.331 µM -0.813592005829424 0.208671565234494 no 2680 0.207939359528432 824 1627241 SGTC_3005 9076496 71.4286 µM -0.813648306250702 0.208655107181882 no 2681 0.207923228016765 872 21368410 SGTC_913 3487-1245 167 µM -0.814767381141014 0.208328131762251 no 2682 0.207602737760248 868 4016153 SGTC_3255 9139072 49.47 µM -0.815787606042292 0.20803030225139 no 2683 0.20731081153126 870 17646060 SGTC_1291 0993-0025 5.79 µM -0.816475918959188 0.207829508328098 no 2684 0.207113995490559 881 4353356 SGTC_3075 9116269 49.47 µM -0.816487179804773 0.207826224277909 no 2685 0.207110776486147 874 17015205 YNL244C SUI1 SGTC_3182 9108849 49.47 µM -0.816923978136363 0.207698862501234 no 2686 0.206985936966757 863 17133045 SGTC_1586 deoxycorticosterone acetate 53.7 µM -0.81711954655653 0.207641853555144 no 2687 0.206930056802174 889 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE. SGTC_2549 cedrol 20.94 µM -0.818680100477543 0.207187277418472 no 2688 0.206484476497826 867 6708665 A sedative which affects the nervous system. SGTC_306 1672-3436 11.6 µM -0.819500188904668 0.206948628729163 no 2689 0.206250547112569 888 6797378 SGTC_610 4215-0184 155 µM -0.819517412167751 0.206943618442235 no 2690 0.206245635879205 857 5605015 SGTC_458 nppb 133 µM -0.820760967413802 0.206582055093103 no 2691 0.20589121788523 885 4549 A chloride channel blocker. SGTC_1596 piperlongumine 63 µM -0.822901160379929 0.205960671378454 no 2692 0.205282101394691 875 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_2301 7769476 200 µM -0.822903626698412 0.205959955947555 no 2693 0.205281400078307 870 977820 SGTC_884 0851-0618 334 µM -0.824479081499769 0.205503248506254 no 2694 0.204833698458871 882 9642473 SGTC_1521 st012942 49.4 µM -0.824854122397684 0.205394616851121 no 2695 0.204727207611224 856 24207259 SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM -0.825755242841437 0.20513374422695 no 2696 0.204471473961277 881 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding. SGTC_2605 digitonin 300 nM -0.825933411584179 0.205082188044925 no 2697 0.204420933049922 868 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_234 nsc-17383 10.7 µM -0.826994973495581 0.204775166568925 no 2698 0.204119955244759 849 408974 SGTC_3232 9132874 49.47 µM -0.828699694838502 0.204282704989582 no 2699 0.203637179250789 855 3784940 SGTC_2644 guaiazulene 100 µM -0.829478381879801 0.20405799193359 no 2700 0.203416882310886 860 3515 A coloring agent. SGTC_2160 5660466 132.927 µM -0.829984593817965 0.20391198859846 no 2701 0.203273747098565 889 2859134 SGTC_1537 2',6'-dihydroxyflavanone 78 µM -0.830557974424771 0.203746687467137 no 2702 0.203111692064921 893 5106787 A p450 inhibitor. SGTC_2089 5281248 129.67 µM -0.831576618172084 0.203453217567513 no 2703 0.202823982248609 873 2737878 SGTC_2578 7,8-dihydroxyflavone 64.44 µM -0.832827475840183 0.203093192305033 no 2704 0.202471018254258 869 1880 Intensifies effect of antibiotics on Staphylococcus aureus. SGTC_1260 0700-1617 7.75 µM -0.833316380503529 0.202952577886 no 2705 0.202333160201445 858 2853078 SGTC_990 3985-0011 41.3 µM -0.833507249471206 0.202897697632657 no 2706 0.202279355492018 886 5399565 YGL099W LSG1 SGTC_886 0866-0150 153 µM -0.835059864155408 0.202451606193271 no 2707 0.201842001642641 896 271463 SGTC_3082 9117008 49.47 µM -0.836463242519943 0.202048897794261 no 2708 0.20144717354226 885 41448529 SGTC_3076 9116187 49.47 µM -0.837173134214213 0.201845372546882 no 2709 0.201247628190936 876 27241210 SGTC_2273 7815444 169.05 µM -0.837461248442159 0.201762805513565 no 2710 0.201166675214147 899 2824616 SGTC_661 1304-0007 33.6 µM -0.837712623871447 0.201690783515085 no 2711 0.201096060885161 886 3117130 SGTC_8 0354-0001 70 µM -0.8383100339166 0.201519680350018 no 2712 0.200928301002169 876 4993152 SGTC_81 0411-0046 9.971 µM -0.843387015515553 0.200069104288591 no 2713 0.199506015703901 875 12925265 SGTC_1733 st037357 54.9 µM -0.843592167679538 0.200010621232729 no 2714 0.199448671252573 897 1272339 YGL099W LSG1 SGTC_1468 k284-1086 134 µM -0.843993636073059 0.199896203736587 no 2715 0.199336480895699 881 15996457 SGTC_480 am 92016 50 µM -0.844971555174428 0.199617663984164 no 2716 0.199063360426659 904 2129 K+ channel blocker. SGTC_3217 9129673 49.47 µM -0.846927326856108 0.199061304523219 no 2717 0.198517814873081 888 17248312 SGTC_152 4469-0003 551.229 µM -0.849304381896722 0.19838636162991 no 2718 0.197855971605441 871 697280 SGTC_422 cantharidin 155 µM -0.850593424437462 0.198020928046298 no 2719 0.197497621705265 895 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_1891 st059073 26.2 µM -0.851115726143657 0.197872975357405 no 2720 0.197352535205937 870 688754 SGTC_893 0958-0369 48.9 µM -0.851371832911503 0.197800452261284 no 2721 0.197281416677524 891 6819948 SGTC_747 3448-8087 38.7 µM -0.852069771713443 0.197602894808451 no 2722 0.19708768410396 913 5168703 SGTC_3239 9133757 49.47 µM -0.852469539964997 0.197489790783384 no 2723 0.196976769043208 906 17036923 SGTC_1432 4049-0298 68.4 µM -0.854276656107102 0.196979002872201 no 2724 0.196475859180794 892 741646 SGTC_3262 9137218 49.47 µM -0.854620995392921 0.196881764912556 no 2725 0.196380500293493 841 17650664 SGTC_1239 0337-0584 35.4 µM -0.855173785117466 0.196725723430789 no 2726 0.196227473293908 902 914301 YML130C ERO1 SGTC_2914 7968218 45.32 µM -0.855850229604094 0.196534878627051 no 2727 0.196040313746295 862 2977111 SGTC_2122 5258151 111.688 µM -0.859098079319207 0.195620128453273 no 2728 0.195143203448138 896 2173356 SGTC_1528 arabinosylhypoxanthine 74.6 µM -0.859539113061159 0.195496111860282 no 2729 0.195021575275609 868 804 An inhibitor of viral and cellular DNA polymerases. SGTC_115 0527-0192 112.043 µM -0.859651104462508 0.195464628013666 no 2730 0.194990697654492 903 4233931 SGTC_1773 st048542 73.5835 µM -0.860127700644433 0.195330678230762 no 2731 0.194859326556746 888 3237138 SGTC_1232 0279-0259 161 µM -0.861287911015914 0.195004828405219 no 2732 0.194539746084591 879 1560000 SGTC_225 nsc-122657 1.016 µM -0.86147422232524 0.194952532925712 no 2733 0.194488456291049 893 275685 SGTC_2118 5526350 200 µM -0.861479782293015 0.194950972436624 no 2734 0.194486925809435 899 743594 SGTC_1784 st039334 36.3 µM -0.861793721145204 0.194862873069373 no 2735 0.194400520359785 910 3496984 SGTC_2988 9073640 71.4286 µM -0.863442599212928 0.194400552879579 no 2736 0.193947083165285 890 9102229 SGTC_3329 9141233 27.5565 µM -0.866384748314135 0.19357727980598 no 2737 0.193139602489013 885 4909101 YNL103W MET4 SGTC_2133 5320837 200 µM -0.8671443956578 0.193365060934862 no 2738 0.192931449079562 911 2841355 SGTC_3026 9090633 49.47 µM -0.867233677972894 0.193340127908208 no 2739 0.192906993546708 889 25236842 SGTC_2657 nystatin 74.44 µM -0.870699235782974 0.192373850908292 no 2740 0.191959197938861 889 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_1855 st056195 39.6 µM -0.871582808564406 0.192127963794619 no 2741 0.191718006303354 863 4028379 SGTC_1220 1838-0075 193 µM -0.872165961030281 0.191965785233656 no 2742 0.191558923051201 878 5529645 SGTC_3019 9081971 49.47 µM -0.872430302725061 0.191892297665407 no 2743 0.191486837616018 905 16451803 SGTC_2150 5556613 200 µM -0.87460840420509 0.191287436452955 no 2744 0.190893506697236 916 743190 SGTC_2452 5863136 48.41 µM -0.87625256597589 0.190831625834656 no 2745 0.190446372778213 900 2184096 SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM -0.876333201958171 0.190809288294842 no 2746 0.190424460177691 913 368090 SGTC_2677 mitomycin C 100 µM -0.876839013791796 0.190669206404893 no 2747 0.190287042560219 917 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_121 0557-0495 61.343 µM -0.877622472080401 0.190452356451061 no 2748 0.190074314976849 911 3104427 SGTC_1518 st038567 90.8 µM -0.878927210194968 0.190091560037902 no 2749 0.18972037203341 911 77966 SGTC_2302 7771753 200 µM -0.880749927626307 0.189588231748962 no 2750 0.189226593431473 882 2203047 SGTC_325 2810-4341 181 µM -0.881759846783631 0.189309704295082 no 2751 0.18895334485059 877 774970 SGTC_1463 k081-0032 34.1 µM -0.882260872129075 0.189171619126903 no 2752 0.188817875283646 852 977755 SGTC_48 0382-0018 55 µM -0.884539642967612 0.188544361016122 no 2753 0.188202486102561 899 762596 SGTC_2433 5607874 27.82 µM -0.889098465046222 0.187293347196187 no 2754 0.186975081895415 888 2252428 SGTC_2621 lithochol-11-enic acid 100 µM -0.891134259410466 0.18673635407881 no 2755 0.18642857373783 915 6708711 SGTC_2843 9000894 45.46 µM -0.891362349499253 0.186674012594926 no 2756 0.186367404747117 852 2242070 SGTC_2697 mebhydrolin 72.4 µM -0.891950106446666 0.186513426511838 no 2757 0.186209837937383 908 22530 H1 Histamine receptor antagonist. YIL048W NEO1 SGTC_47 0149-0135 24.25 µM -0.893390652907413 0.18612020448777 no 2758 0.185824003232111 900 5239155 SGTC_1306 1185-0270 9.02 µM -0.893825651463839 0.186001565206989 no 2759 0.18570759114013 910 1548076 SGTC_3177 9107506 49.47 µM -0.895206099805319 0.185625379374937 no 2760 0.185338462302871 889 8897194 SGTC_906 1165-0455 526 µM -0.895505549960505 0.185543838597553 no 2761 0.185258450159409 903 3252859 SGTC_3204 9114183 49.47 µM -0.895656834785136 0.185502651940431 no 2762 0.185218035485021 898 17027248 SGTC_981 1488-1094 54.9 µM -0.896164002151613 0.185364619159853 no 2763 0.185082589248081 890 3449522 SGTC_743 1275-0778 158 µM -0.896221263905754 0.185349038569779 no 2764 0.1850673005513 902 2849257 YMR203W TOM40 SGTC_3165 9101544 49.47 µM -0.898294248324577 0.184785539188904 no 2765 0.184514349054972 907 5002184 SGTC_3014 9081533 49.47 µM -0.89975559728785 0.184388941341608 no 2766 0.184125164455669 907 21367265 SGTC_1478 0453-0656 35.7 µM -0.902917647755486 0.183532601672925 no 2767 0.183284801815296 920 5258496 SGTC_2687 chenodiol 100 µM -0.903491287541572 0.183377515828502 no 2768 0.183132605085642 884 5702181 A cholesterol synthesis inhibitor. SGTC_392 N-ethylmaleimide 8.33 µM -0.904646245877227 0.183065516096371 no 2769 0.182826413550354 883 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides. SGTC_938 3126-1755 342 µM -0.905325140643638 0.182882274525425 no 2770 0.182646580658126 887 1777771 SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM -0.905715034948786 0.182777089299288 no 2771 0.182543351243188 920 6708561 SGTC_737 1950-0117 57.9 µM -0.906884537483535 0.182461808879503 no 2772 0.182233929392394 903 5393513 SGTC_3160 9100216 49.47 µM -0.907098756360171 0.182404095503478 no 2773 0.18217728784193 885 17191039 SGTC_2673 kobusone 100 µM -0.9074598728467 0.182306831804512 no 2774 0.182081830050796 935 6710676 An epoxy ketone and protein crosslinker. SGTC_186 3455-3465 67.277 µM -0.907979003938294 0.18216706499111 no 2775 0.181944657365099 884 755278 SGTC_527 4476-4215 268 µM -0.908467371164617 0.182035641960075 no 2776 0.181815672583969 871 4418754 SGTC_1169 aniline yellow 25.8 µM -0.908494507661315 0.182028341078245 no 2777 0.181808507124245 891 6051 A DNA damaging agent. SGTC_2198 6589944 200 µM -0.909522641710527 0.181751863792155 no 2778 0.181537155903225 891 5290268 SGTC_1096 rimcazole 32.2 µM -0.909720260588514 0.181698751878394 no 2779 0.181485028218128 894 18528119 A dopamine reuptake inhibitor. SGTC_1930 st074634 34.3 µM -0.910230742740987 0.181561599993286 no 2780 0.181350417178185 919 684253 YOR116C RPO31 SGTC_691 1548-0686 185 µM -0.911965148521017 0.181096099217546 no 2781 0.18089353211515 893 46495133 SGTC_445 e6 berbamine 66 µM -0.912997447169987 0.180819393701596 no 2782 0.18062194208352 902 6610268 A calcium/calmodulin antagonist. SGTC_556 4058-0063 51.5 µM -0.913110851618425 0.180789012038614 no 2783 0.180592121820033 921 6615692 SGTC_3027 9089541 49.47 µM -0.917742631721348 0.179550868581979 no 2784 0.179376811407182 911 9943819 SGTC_1865 st057639 52.2 µM -0.918470860319716 0.179356688241961 no 2785 0.179186203881915 916 688818 SGTC_582 0987-0078 156 µM -0.918763511557461 0.179278690726898 no 2786 0.179109640854894 919 1625765 SGTC_1942 st076330 65.2 µM -0.920958210489077 0.178694438752575 no 2787 0.178536122701821 911 24208414 SGTC_105 0111-0055 734.78 µM -0.930370883054007 0.176202304485086 no 2788 0.176089544396465 919 5179370 SGTC_2368 9071271 200 µM -0.930638021619287 0.176131898401525 no 2789 0.176020419864196 920 27209959 SGTC_2456 5770359 74.46 µM -0.930665538586139 0.176124647140058 no 2790 0.176013300574991 915 3118787 SGTC_999 SEC7.066 22.7 µM -0.932245246381211 0.175708679949292 no 2791 0.175604898548613 916 740511 YDR170C SEC7 SGTC_2187 6125751 200 µM -0.932751996415361 0.175575374964043 no 2792 0.175474015720814 915 874498 SGTC_217 ketoconazole 989 nM -0.933369272613258 0.175413081723146 no 2793 0.175314669876562 870 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4 SGTC_1299 1079-1439 3.74 µM -0.934537483583636 0.175106198014126 no 2794 0.175013355013197 925 323161 SGTC_545 4218-0007 221 µM -0.935343549798463 0.174894646779581 no 2795 0.174805639281579 929 2840508 SGTC_2521 angolensin 13.4 µM -0.936677636796613 0.174544873577315 no 2796 0.174462201493785 910 821428 A flavenoid. SGTC_137 0438-0332 85.389 µM -0.938831318488456 0.173981155819769 no 2797 0.173908678228258 912 2063393 YER012W | YPR107C PRE1 | YTH1 SGTC_1060 3448-7350 82 µM -0.939158373283388 0.173895651858151 no 2798 0.173824718812914 930 570178 SGTC_280 3448-3607 3.04 µM -0.939918764704701 0.173696961325362 no 2799 0.173629615655435 896 626179 SGTC_1015 4130-4525 82 µM -0.943098920239171 0.172867551551258 no 2800 0.172815153996743 916 1363237 SGTC_2831 7999036 19.48 µM -0.945040987704432 0.172362288315174 no 2801 0.172318975467947 943 2988270 SGTC_817 1391-0715 46 µM -0.945351647128281 0.172281552255856 no 2802 0.172239689541619 912 1353946 SGTC_2211 7117706 200 µM -0.948107600620135 0.171566375080123 no 2803 0.171537339650416 909 822771 SGTC_1502 4534-4282 27.7 µM -0.949630883295651 0.171171894432161 no 2804 0.171149920191947 933 3278949 SGTC_783 0848-0141 92.7 µM -0.951756115026829 0.170622498505608 no 2805 0.170610341567742 906 6755076 YHR007C | YLR033W ERG11 | RSC58 SGTC_2567 aureobasidin a 60 nM -0.952927289968618 0.170320219830889 no 2806 0.170313455976485 912 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1 SGTC_67 0335-0847 266 µM -0.955895165232526 0.169555752425736 no 2807 0.169562600933232 943 4552207 YOR254C SEC63 SGTC_1570 verbenone 133 µM -0.956504174964971 0.169399155902656 no 2808 0.169408788051564 929 29025 A natural terpanoid with antifungal properties. SGTC_2651 TUB2.036 5 µM -0.958298675393926 0.168938270451742 no 2809 0.168956085785195 891 15992207 YFL037W TUB2 SGTC_2243 6634756 200 µM -0.961143759284187 0.168209213942424 no 2810 0.168239944935043 913 885676 SGTC_2682 pyrogallin 40.03 µM -0.961905443803522 0.168014375268088 no 2811 0.168048551890469 910 822798 An ATP competetive kinase inhibitor. SGTC_2875 9039966 71.43 µM -0.963162716783782 0.167693083095201 no 2812 0.167732936015959 934 6463691 SGTC_3218 9131285 49.47 µM -0.964351442886538 0.16738967201559 no 2813 0.167434878904015 930 17156417 SGTC_1199 1638-0010 4.46 µM -0.965128810984341 0.167191447601909 no 2814 0.167240148961341 915 3111136 SGTC_1912 st060209 90.8 µM -0.96766776516113 0.16654508355151 no 2815 0.166605160925668 925 688787 SGTC_1727 st034309 9.9045 µM -0.968076783790546 0.166441107110643 no 2816 0.166503011796091 948 870305 SGTC_2048 5246248 200 µM -0.970780589906365 0.165754828288122 no 2817 0.165828775126653 894 677046 SGTC_2467 5474540 200 µM -0.973263091781148 0.165126334114229 no 2818 0.165211280495356 890 5413519 SGTC_816 0325-0417 81.3 µM -0.973591551398668 0.16504329380733 no 2819 0.165129691451067 904 68101 SGTC_455 paf C-16 10 µM -0.976360311035181 0.164344377964747 no 2820 0.164442971113184 920 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis. SGTC_752 1896-0090 130 µM -0.978892937646985 0.163706751907409 no 2821 0.163816441039218 915 772567 SGTC_412 gemfibrozil 100 µM -0.981351184344081 0.163089390077799 no 2822 0.163209795005955 907 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels. SGTC_725 1497-0963 19 µM -0.981999577956964 0.162926805628947 no 2823 0.163050028065941 920 3549977 SGTC_1348 1493-0373 93.8 µM -0.982423430938487 0.162820581635828 no 2824 0.162945643857881 933 3010129 SGTC_2337 9009472 200 µM -0.983168868135588 0.162633873036676 no 2825 0.162762167059854 900 5742383 SGTC_1147 3809-1045 12.3 µM -0.983479945342031 0.162555999175632 no 2826 0.162685640401464 910 325925 SGTC_2422 chlorphenesin carbamate 384.24 µM -0.985598760067683 0.162026228845427 no 2827 0.162165023367348 916 2724 A muscle relaxant with antifungal properties. SGTC_1565 sinapyl alcohol 95.1 µM -0.989100978616397 0.161153032466572 no 2828 0.161306869436972 920 5280507 A phenol propionate derived from cinnamic acid. SGTC_2812 7970281 58.44 µM -0.989226470873111 0.161121800990226 no 2829 0.161276174949209 959 2233435 SGTC_451 chloral hydrate 100 µM -0.989335226163078 0.161094738066546 no 2830 0.16124957728287 940 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1 SGTC_2005 4024620 188 µM -0.990480955619955 0.160809812275177 no 2831 0.16096954658151 934 236743 SGTC_1403 3909-7815 62.9 µM -0.991014414695526 0.160677261308363 no 2832 0.160839270834195 906 6615483 SGTC_3033 9090887 49.47 µM -0.991795749444417 0.160483248388453 no 2833 0.160648585782749 933 19325384 SGTC_1405 3909-7894 12 µM -0.992192088150354 0.160384892215946 no 2834 0.160551915633254 898 7104060 SGTC_463 ikarugamyin 104 µM -0.995487311880756 0.159568668699921 no 2835 0.159749656125583 962 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis. SGTC_1681 tripelennamine 100 µM -0.999185626197048 0.158655843703425 no 2836 0.158852388788638 905 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist. SGTC_2420 aureobasidin a 50 nM -1.0000316279021 0.158447514093274 no 2837 0.158647601026096 933 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1 SGTC_253 dyclonine 31.25 µM -1.00109632198465 0.158185586174202 no 2838 0.158390121521452 931 3180 An oral anasthetic. SGTC_129 0088-0017 176.636 µM -1.00160774654496 0.158059870493799 no 2839 0.158266539063881 935 182446 SGTC_805 3852-0218 479 µM -1.00196258054832 0.157972685624506 no 2840 0.158180832895985 928 6615355 SGTC_7 0192-1582 4.227 µM -1.00216835661077 0.157922139663845 no 2841 0.158131143956282 958 252616 SGTC_3132 9126706 49.47 µM -1.00274686251811 0.157780094822618 no 2842 0.1579915064819 917 850858 SGTC_2496 diffractaic acid 79.83 µM -1.00277007470237 0.157774397114682 no 2843 0.157985905306222 929 94870 An apoptosis inducer which activates caspases. SGTC_521 r062-0005 13.8 µM -1.00428031848577 0.157403980171076 no 2844 0.157621758747628 930 2832033 SGTC_1318 1280-3875 124 µM -1.01176662392698 0.155576262891844 no 2845 0.155824825868512 941 373245 SGTC_1990 st072050 59.8 µM -1.01259370960226 0.155375199235728 no 2846 0.15562713285122 913 17233948 SGTC_524 r073-0010 27.8 µM -1.01268398637717 0.155353263431198 no 2847 0.155605564587183 941 2772106 SGTC_1895 st058434 18.3 µM -1.01278653694553 0.155328347771736 no 2848 0.155581066350607 965 5393175 SGTC_3138 9097216 49.47 µM -1.01605740191365 0.154535042754215 no 2849 0.154801026305012 927 25237486 SGTC_3164 9100705 49.47 µM -1.01624687776034 0.154489170099878 no 2850 0.154755919169945 905 17174235 SGTC_2792 7535235 81.82 µM -1.01645117582631 0.154439719029096 no 2851 0.154707293147449 937 1281891 SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM -1.01796778170313 0.154072946413602 no 2852 0.154346633737757 945 364106 SGTC_281 1672-3440 14.9 µM -1.02018567230652 0.153537615011154 no 2853 0.15382020570546 937 6833000 SGTC_1456 k015-0012 13 µM -1.02087404053582 0.153371714623808 no 2854 0.15365705982292 931 2989616 SGTC_309 k408-0051 1.48 µM -1.02174483418016 0.15316201893562 no 2855 0.153450842616082 910 3640463 SGTC_2529 gangaleoidin 93.61 µM -1.02196636515556 0.153108702426389 no 2856 0.15339840996775 938 4565183 SGTC_525 k781-2675 26.7 µM -1.02379673235595 0.152668653336354 no 2857 0.152965647058857 894 3651118 YDL195W SEC31 SGTC_2274 7947094 46.08 µM -1.02413865686792 0.152586542396054 no 2858 0.152884893944059 929 2971028 SGTC_1667 st014849 34.6 µM -1.02734987374059 0.151816819569707 no 2859 0.152127872884623 933 5348460 SGTC_2983 9022671 12.99 µM -1.0288492201026 0.151458314043623 no 2860 0.151775266750587 919 6405161 SGTC_3155 9099265 49.47 µM -1.03001372826223 0.151180259658526 no 2861 0.151501780599026 941 25236499 SGTC_1139 k015-0024 46.9 µM -1.03361725683871 0.150321982957272 no 2862 0.15065756433314 951 2766652 SGTC_3337 9144342 33.5465 µM -1.0343304279156 0.15015250783553 no 2863 0.150490858322446 922 17682949 SGTC_2973 9094665 17.96 µM -1.03481004703868 0.150038604721726 no 2864 0.150378814958476 929 25237061 YIL048W NEO1 SGTC_1619 st003326 88.7 µM -1.03630668950827 0.149683542640266 no 2865 0.150029543153072 870 2849032 SGTC_1674 st016616 23.6 µM -1.04080296032732 0.148620225782535 no 2866 0.148983502932021 932 625830 SGTC_1008 4106-0037 6 µM -1.04162373921421 0.148426667320177 no 2867 0.148793079039432 939 2905394 SGTC_1846 st056244 14.8 µM -1.04387010361778 0.14789778559169 no 2868 0.148272745888234 940 5393182 SGTC_2063 5246145 200 µM -1.04503247324672 0.147624614391651 no 2869 0.148003980668614 950 711240 SGTC_2145 5634607 200 µM -1.0465337449433 0.147272297448412 no 2870 0.147657336727933 957 308662 SGTC_2258 7960471 200 µM -1.04780900335799 0.146973464122586 no 2871 0.147363306774328 965 2974708 SGTC_1062 mesoridazine 14.2 µM -1.04960222793429 0.146553943367289 no 2872 0.146950516165703 920 4078 A neuroleptic. SGTC_2526 patulin 37.61 µM -1.04988883108156 0.146486967788258 no 2873 0.146884613616377 946 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.  SGTC_88 0180-0332 8.668 µM -1.05052995833585 0.146337218747509 no 2874 0.146737262314555 941 3101745 SGTC_858 0438-0351 2.77 µM -1.05207835250175 0.145975982055259 no 2875 0.146381801536365 946 2799119 SGTC_2138 5575593 77.673 µM -1.05376831008024 0.145582403336079 no 2876 0.145994502764672 945 762213 SGTC_1464 k208-0027 110 µM -1.05388823540684 0.145554500747388 no 2877 0.14596704487014 917 X1464 SGTC_303 1348-1668 34.2 µM -1.05746437689652 0.144724105335708 no 2878 0.14514985211448 943 5380509 SGTC_2293 7624732 200 µM -1.05898085417297 0.144372938072714 no 2879 0.144804249615042 922 894453 SGTC_1766 st045414 44.774 µM -1.06058485549386 0.14400212850048 no 2880 0.144439304036631 928 253960 SGTC_1278 0874-0585 172 µM -1.06084660730542 0.143941678296121 no 2881 0.14437980861832 946 766306 SGTC_2362 9071156 126 µM -1.06143033689321 0.143806930673024 no 2882 0.144247188089808 961 653133 SGTC_285 1486-1325 46 µM -1.06488460202411 0.14301129335952 no 2883 0.143464076935498 933 22310230 SGTC_1955 wogonin 32.4 µM -1.06637532832348 0.142668847810865 no 2884 0.143127004922001 927 5281703 A flavanone. SGTC_2185 6113692 200 µM -1.06834089667 0.14221817093842 no 2885 0.142683383504062 950 874150 SGTC_947 3447-0010 211 µM -1.06835712833691 0.142214453263097 no 2886 0.142679723952037 951 748350 SGTC_728 3030-5151 22.5 µM -1.06928032789786 0.142003113332373 no 2887 0.142471686076878 951 3125388 SGTC_3102 9121669 49.47 µM -1.07019913083962 0.141792991078787 no 2888 0.142264842756531 968 41905072 SGTC_578 3460-0051 92 µM -1.07040820032069 0.141745208127015 no 2889 0.142217804880941 974 2876744 SGTC_2587 piperic acid 92.2 µM -1.0704902277772 0.141726463683264 no 2890 0.142199352660107 939 5370536 SGTC_2279 7948423 32.93 µM -1.07280990112357 0.141197080265614 no 2891 0.14167820874849 931 1247112 SGTC_2132 5317594 122.667 µM -1.07559162128547 0.140564020898727 no 2892 0.141054968137723 951 794577 SGTC_592 k241-0073 46.5 µM -1.07569560071817 0.140540394841774 no 2893 0.141031707792357 953 4230158 SGTC_1241 0364-0022 50.8 µM -1.0779128934595 0.140037226387092 no 2894 0.140536315454184 970 4563895 SGTC_2096 5468907 200 µM -1.07856560525392 0.139889340510335 no 2895 0.140390710493482 944 759785 SGTC_148 3253-0744 288.01 µM -1.0788001538748 0.139836224416258 no 2896 0.140338413128099 929 6893655 SGTC_2810 7959871 45.46 µM -1.07989840022973 0.13958769693765 no 2897 0.140093712874204 933 2974535 SGTC_3099 9120367 49.47 µM -1.08001298383973 0.139561784573618 no 2898 0.140068199211694 956 24824940 SGTC_103 0844-0104 51.839 µM -1.08002005941698 0.139560184583491 no 2899 0.140066623837774 952 5375804 SGTC_1025 k007-0731 70 µM -1.08207052533531 0.139097041233724 no 2900 0.139610595770892 942 6256118 SGTC_3317 9138495 8.753 µM -1.08246091616487 0.139008981467516 no 2901 0.139523886545232 940 17020139 SGTC_2149 5554786 194.827 µM -1.08278340241982 0.138936267446024 no 2902 0.139452287151058 964 745063 YPR165W RHO1 SGTC_676 falcarinol 140 µM -1.08556609232315 0.138309903963794 no 2903 0.138835504057483 945 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer. SGTC_2030 5175110 200 µM -1.08900121326542 0.137539341436417 no 2904 0.138076675328514 974 2831986 SGTC_2512 diallyl trisulfide 49.23 µM -1.08900381489078 0.137538758955488 no 2905 0.13807610169547 984 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent SGTC_2014 4013930 200 µM -1.09144796592363 0.136992278953674 no 2906 0.137537908075699 965 64556 SGTC_1815 st051655 58.2 µM -1.09446163153854 0.13632050810018 no 2907 0.136876283113228 951 5984156 SGTC_433 pimozide 108 µM -1.09446496592444 0.136319766088537 no 2908 0.136875552283639 957 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic SGTC_1112 tnp00069 1.16933 µM -1.09641023378883 0.13588735036302 no 2909 0.136449643714503 951 145826 SGTC_733 4069-0007 56.1 µM -1.096412034599 0.135886950494584 no 2910 0.136449249854819 973 5717425 YNL287W SEC21 SGTC_3031 9088762 49.47 µM -1.09909238450639 0.135292673895295 no 2911 0.135863885665817 972 205253 SGTC_3309 9129340 25.759 µM -1.1024663937743 0.134547138067068 no 2912 0.135129480447082 945 17158987 SGTC_1380 2291-0730 164 µM -1.10642179370011 0.13367673256776 no 2913 0.134271998414029 961 2999191 SGTC_1706 st031321 9.9705 µM -1.1083816883826 0.133246885451592 no 2914 0.133848504894267 954 6103185 SGTC_1082 camptothecin 424.86 nM -1.10908127116537 0.133093682463716 no 2915 0.133697561807478 928 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_386 1509-0011 3.07 µM -1.11057149608316 0.132767739541273 no 2916 0.133376418801176 954 3107280 SGTC_1228 0124-0032 52.5 µM -1.11320909731103 0.132192190229889 no 2917 0.13280931822182 948 X1228 SGTC_611 3453-1652 23.7 µM -1.114428879471 0.131926604854773 no 2918 0.132547619826792 957 1560575 SGTC_2190 6049624 200 µM -1.11499099151854 0.131804339147995 no 2919 0.132427141057048 937 2265554 SGTC_934 2950-0684 338 µM -1.11726246253607 0.131311064950651 no 2920 0.131941060186592 961 1121253 SGTC_791 1348-1292 225 µM -1.12160219530592 0.130372193479115 no 2921 0.131015808913376 975 5437054 SGTC_2189 6047310 154.431 µM -1.122657020825 0.130144692432123 no 2922 0.130791594073758 952 711535 SGTC_2404 5161160 200 µM -1.12298410882441 0.13007420308164 no 2923 0.130722121802129 945 2831543 SGTC_1862 st057513 3.81 µM -1.12314947925293 0.130038574859054 no 2924 0.130687007450189 960 5393163 SGTC_1187 1391-0724 117 µM -1.12400059195056 0.129855313776217 no 2925 0.130506387410989 966 6997986 SGTC_472 calcifediol 10 µM -1.12418371008936 0.129815908273567 no 2926 0.130467549323675 976 5283731 A vitamin D metabolite. SGTC_573 3702-0553 84.7 µM -1.12468052681034 0.12970903915036 no 2927 0.1303622182089 952 1222756 SGTC_1137 ixabepilone 100 µM -1.12481998901844 0.129679050705368 no 2928 0.130332661121762 952 154225 A novel microtubule stabilizer. SGTC_404 fumagillin 50 µM -1.12490520334945 0.129660729500838 no 2929 0.130314603404171 950 12015870 A methionine aminopeptidase binder. SGTC_2731 amoxapine 43.43 µM -1.12567353271157 0.129495618531796 no 2930 0.130151865348037 1001 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine. SGTC_704 1310-0270 142 µM -1.12569817315895 0.129490325808064 no 2931 0.130146648640608 947 5718033 SGTC_3288 9119690 36.221 µM -1.12801317564846 0.128993735838572 no 2932 0.129657177397152 985 17595618 YKL019W RAM2 SGTC_2749 bexarotene 57.39 µM -1.12810580478341 0.128973893527303 no 2933 0.129637618973231 955 82146 An retinoic acid receptor inhibitor. SGTC_2734 clemastine 41.6 µM -1.1287453934455 0.128836943457953 no 2934 0.129502627102568 1008 26987 Clemastine is a selective histamine H1 antagonist. SGTC_1365 1672-3266 55.4 µM -1.12875095199034 0.128835753692952 no 2935 0.129501454340623 935 6415873 SGTC_2603 homopterocarpin 100 µM -1.13302792974284 0.127922556766905 no 2936 0.128601262297151 957 101795 A weak amylase inhibitor. SGTC_621 3584-0052 32.1 µM -1.135378816218 0.127422528253369 no 2937 0.12810831579828 952 2273927 SGTC_1441 4106-0040 13 µM -1.13658835778813 0.127165791634195 no 2938 0.127855204620855 958 2904180 SGTC_1059 3448-6867 171 µM -1.13897873285917 0.126659470991755 no 2939 0.127356012314483 951 3934407 SGTC_401 neomycin 50 µM -1.13997341443926 0.126449195332982 no 2940 0.127148688626125 940 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis. SGTC_1285 0929-0069 65.5 µM -1.14101937423424 0.126228341931565 no 2941 0.126930930338622 967 1206237 SGTC_2922 7999257 32.47 µM -1.14167960913673 0.126089072459096 no 2942 0.126793609808952 981 2988377 SGTC_341 1486-1430 230 µM -1.14530902251891 0.125325399718183 no 2943 0.126040584888652 960 2054753 YPL210C SRP72 SGTC_1424 4048-1941 275 µM -1.14588171476581 0.125205193876197 no 2944 0.125922049023033 954 X1424 SGTC_2453 5731132 22.18 µM -1.14613644481273 0.125151752921376 no 2945 0.12586934997418 982 1362040 SGTC_2197 6588183 93.1375 µM -1.14683584291472 0.125005104983837 no 2946 0.125724736231422 945 884136 SGTC_1812 st052057 4.327 µM -1.14936270912544 0.124476278782996 no 2947 0.125203225037169 972 3645418 SGTC_1040 k898-0338 155 µM -1.15165013065564 0.123998914546388 no 2948 0.124732436268584 969 20969351 SGTC_3169 9102970 49.47 µM -1.15194856906387 0.123936727745857 no 2949 0.12467110411886 995 17027839 SGTC_153 4077-0274 519.67 µM -1.15549918446687 0.123198546186579 no 2950 0.123943033192913 943 3121976 SGTC_1177 0983-0204 23.6 µM -1.16000927193115 0.122265338220035 no 2951 0.123022515561598 946 766818 SGTC_45 0kpi-0036 14.9 µM -1.16022082508422 0.122221686718758 no 2952 0.122979455139853 975 2795021 SGTC_1013 4112-3890 241 µM -1.16135515466656 0.121987817782046 no 2953 0.122748749136832 956 705171 SGTC_1427 4048-4900 550 nM -1.16663151018504 0.120904103705875 no 2954 0.121679606283097 960 24132586 SGTC_2991 9074669 71.4286 µM -1.17260753354173 0.119684887449552 no 2955 0.120476613476188 964 17333109 SGTC_1396 3511-0007 98.6 µM -1.17354186800728 0.119495053001342 no 2956 0.120289288710024 960 X1396 SGTC_2939 9044578 71.43 µM -1.17409445162144 0.119382881225222 no 2957 0.120178597803044 979 2653634 SGTC_829 1635-0120 117 µM -1.17609262660033 0.118977881643642 no 2958 0.119778932022294 950 285054 SGTC_2303 7774051 200 µM -1.17782689104113 0.118627159959146 no 2959 0.11943281289055 966 2953184 SGTC_3343 9148379 18.9835 µM -1.17858752097046 0.118473567842175 no 2960 0.119281231560888 935 1955036 SGTC_1312 1218-2183 165 µM -1.17933737127613 0.118322290059032 no 2961 0.119131931390557 969 6744073 SGTC_827 3253-0474 693 µM -1.17973015204291 0.118243103428995 no 2962 0.119053778805634 966 5402065 SGTC_1583 clindamycin 39.6 µM -1.17994774494619 0.118199251709147 no 2963 0.119010499378584 985 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis. SGTC_868 0527-0199 213 µM -1.1801396293571 0.118160590591201 no 2964 0.118972342613147 970 2849450 SGTC_3230 9131665 49.47 µM -1.18036620150672 0.118114952057652 no 2965 0.118927299214877 937 15943720 SGTC_945 3381-0768 11.3 µM -1.18182225006441 0.117821957000908 no 2966 0.118638118647142 970 1126236 YIL048W NEO1 SGTC_529 4076-0302 30.3 µM -1.18697413008353 0.116789394297246 no 2967 0.117618912460162 979 5816522 SGTC_2610 ononetin 44.17 µM -1.18748824649654 0.116686705922559 no 2968 0.117517544988405 994 259632 SGTC_438 sphingosine 6.67 µM -1.18831705146448 0.116521297233963 no 2969 0.117354261155532 985 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes. SGTC_801 0866-0028 10.1 µM -1.18893530266428 0.116398018140755 no 2970 0.117232563440305 967 6849771 SGTC_2117 5521686 200 µM -1.19299631815596 0.115590552656058 no 2971 0.11643540750224 981 803312 SGTC_589 1227-0070 34.1 µM -1.19573088573436 0.115049076212737 no 2972 0.115900797245899 968 2841384 SGTC_888 0916-0002 6.97 µM -1.19831767461604 0.11453852413648 no 2973 0.115396684172301 970 2802138 YIL048W NEO1 SGTC_1421 4029-0249 71.4 µM -1.1987846383643 0.114446532038147 no 2974 0.115305848628442 975 2894095 SGTC_375 3970-0961 9.27 µM -1.2010918536612 0.11399278137437 no 2975 0.114857786346757 953 2898222 SGTC_1027 k015-0025 8.67 µM -1.20230928451707 0.113753871438187 no 2976 0.114621860528357 968 3598955 SGTC_2314 7727897 200 µM -1.20309537431849 0.113599798075453 no 2977 0.114469707608201 933 900724 SGTC_2321 7390090 138.78 µM -1.20332698217776 0.113554431394001 no 2978 0.114424905796522 993 649046 SGTC_1624 st003710 6.25 µM -1.20348247035234 0.113523982065601 no 2979 0.114394835445194 979 24207033 SGTC_1771 st048882 4.1505 µM -1.20509675031371 0.11320820074569 no 2980 0.114082977096288 978 4580403 SGTC_2038 4100038 30.985 µM -1.21115063909169 0.112029537648882 no 2981 0.112918838307568 951 3596803 SGTC_3077 9117319 49.47 µM -1.21411878439772 0.111454870130109 no 2982 0.11235118393865 996 17154678 SGTC_2541 muurolladie-3-one 83.07 µM -1.21659145117265 0.110977746291908 no 2983 0.111879848478396 946 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils.  YMR203W TOM40 SGTC_3093 9117344 49.47 µM -1.2202212477223 0.110279996542603 no 2984 0.111190507115391 959 24824913 SGTC_2253 7938677 135.83 µM -1.22051793849348 0.110223103570706 no 2985 0.111134296764548 992 2301972 SGTC_1007 4101-0031 70 µM -1.22113273967544 0.11010527724449 no 2986 0.111017882723636 1002 1146276 SGTC_3087 9117406 49.47 µM -1.22226493165768 0.109888529709409 no 2987 0.110803728096552 960 42546093 SGTC_1830 st055982 50.3 µM -1.22396024846003 0.10956455001604 no 2988 0.110483611840939 987 455313 An antimicrobial agent. SGTC_638 3970-0837 4.09 µM -1.22490328071824 0.109384631117847 no 2989 0.110305832094893 962 4118451 YLR208W SEC13 SGTC_1136 pergolide 1.05886 µM -1.2267891747345 0.109025462623968 no 2990 0.109950920290277 983 47811 A dopamine receptor agonist. SGTC_2771 fluoxetine 41.05 µM -1.22720602378505 0.108946188244102 no 2991 0.109872582972977 969 3386 A selective serotonin reuptake inhibitor. SGTC_2849 9019321 12.99 µM -1.22724157307799 0.108939429565813 no 2992 0.10986590414441 968 16489627 SGTC_1335 1486-0900 202 µM -1.23104152345498 0.108218715154246 no 2993 0.10915366723912 974 X1335 SGTC_2476 5806916 10.51 µM -1.2343351277086 0.107596818253875 no 2994 0.108539025715439 947 2870194 SGTC_1450 4112-4260 37.6 µM -1.23796007457963 0.106915338840177 no 2995 0.107865432614421 970 1633175 SGTC_1345 1488-0192 31.4 µM -1.23844870914874 0.106823715663591 no 2996 0.107774864580732 983 658348 SGTC_1793 st048256 72.231 µM -1.23865584015682 0.106784893924136 no 2997 0.107736489547128 973 672022 SGTC_2265 7929201 200 µM -1.24302910428056 0.105967605858473 no 2998 0.106928554373391 973 1265108 SGTC_364 0083-0097 67.7 µM -1.24463258241216 0.105669078700849 no 2999 0.10663341894712 1009 5207356 SGTC_1034 k072-0165 12.7 µM -1.24657041133995 0.10530911590996 no 3000 0.106277528295756 1004 5835461 SGTC_872 0588-0139 234 µM -1.24916638899324 0.104828289650307 no 3001 0.105802111292338 974 2047100 SGTC_3339 9145883 14.936 µM -1.25006969217862 0.104661353456554 no 3002 0.105637045008619 942 2030670 SGTC_1864 st057645 30.4 µM -1.2524455813827 0.104223193411531 no 3003 0.105203772963192 986 688666 SGTC_2791 5663188 71.43 µM -1.2525041849221 0.104212402610565 no 3004 0.105193102175406 972 54690634 SGTC_2608 thymoquinone 42.66 µM -1.25331296983918 0.104063561937163 no 3005 0.105045915077891 987 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC). SGTC_1671 st016596 74.5 µM -1.25551075128869 0.103659882885147 no 3006 0.104646703828945 997 2829167 SGTC_185 k048-0037 25.491 µM -1.25617373581737 0.103538332097435 no 3007 0.104526493462508 984 6827589 SGTC_71 0417-1750 47.813 µM -1.25668450553828 0.103444758755364 no 3008 0.104433950476511 938 6811472 SGTC_647 0140-0236 81 µM -1.26001461797907 0.102836184424548 no 3009 0.103832044483693 1004 990837 SGTC_1618 st003135 44.5 µM -1.26306359937666 0.102281271605707 no 3010 0.103283162155353 1000 1270615 SGTC_3057 9095946 49.47 µM -1.26344202621075 0.102212550364024 no 3011 0.103215184409474 1008 24540043 SGTC_2322 7413319 38.22 µM -1.26552985298844 0.101834010691148 no 3012 0.102840726945921 953 1840400 SGTC_2379 9035213 200 µM -1.26557713025678 0.101825450775805 no 3013 0.102832259082351 969 646551 SGTC_793 0488-0545 106 µM -1.26707215356933 0.101555035325312 no 3014 0.102564745710577 990 292548 SGTC_14 0354-0009 295 µM -1.26783004593717 0.101418149898739 no 3015 0.102429324944537 993 1713507 SGTC_700 3453-2283 142 µM -1.2678511162039 0.101414346249862 no 3016 0.102425561952167 978 565664 SGTC_1748 st037455 53.6035 µM -1.26826976919391 0.101338791674654 no 3017 0.102350814493141 1003 580690 SGTC_926 2268-1401 59.4 µM -1.26834046546235 0.10132603712164 no 3018 0.10233819610252 985 2931578 SGTC_2784 7567673 72.73 µM -1.26934688760617 0.101144591914337 no 3019 0.1021586851463 961 3471247 SGTC_3202 9113761 49.47 µM -1.27208153685477 0.100652765246924 no 3020 0.101672075227075 985 4798415 SGTC_932 2857-0803 154 µM -1.27261684815794 0.100556694010811 no 3021 0.101577018514011 984 674898 SGTC_2034 5197015 53.07 µM -1.27330488622343 0.100433311482107 no 3022 0.101454936757151 997 780676 SGTC_19 0279-0214 38.434 µM -1.27457475771393 0.100205881742117 no 3023 0.101229898333502 993 3566274 YBR002C RER2 SGTC_2889 9059656 51.95 µM -1.27510470851958 0.100111080589122 no 3024 0.101136091520725 1002 3949838 SGTC_3028 9087778 49.47 µM -1.27679637125058 0.099808902764861 no 3025 0.100837073500375 970 17217395 SGTC_2940 9060638 45.86 µM -1.27837853870374 0.0995268873118258 no 3026 0.100557993725632 970 4027022 SGTC_994 3910-0338 138 µM -1.2805444345236 0.0991417693732283 no 3027 0.100176863898042 989 3479481 SGTC_724 3910-0327 137 µM -1.28146555596082 0.098978315487275 no 3028 0.100015095370399 995 2885483 SGTC_1540 guanosine 70.6 µM -1.28516490513097 0.0983238480657344 no 3029 0.0993673322799198 978 6802 Guanosine is a purine nucleoside SGTC_1794 st048918 76.9 µM -1.28560716791684 0.0982458180934953 no 3030 0.0992900969430144 919 672303 SGTC_2636 apigenin dimethyl ether 100 µM -1.28672207937237 0.0980493116802191 no 3031 0.0990955872398048 995 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_561 1550-0330 72.9 µM -1.28852935932284 0.0977313853370736 no 3032 0.0987808778112966 994 6812934 SGTC_537 1334-0398 209 µM -1.28934354931647 0.0975884048865878 no 3033 0.0986393386213347 983 5846986 SGTC_1180 1193-0155 285 µM -1.28967234168409 0.0975307089394751 no 3034 0.0985822232917848 1010 2921347 SGTC_18 0111-0177 500 nM -1.29185055939617 0.0971491105961971 no 3035 0.0982044511193447 1005 721752 SGTC_1433 4060-0023 7.6 µM -1.30346012620712 0.0951337207808294 no 3036 0.0962088604198822 990 3840627 SGTC_2895 9054447 58.44 µM -1.30553295991259 0.0947771456253653 no 3037 0.0958557157273016 1018 2697450 SGTC_654 1124-0271 80.9 µM -1.30899138366139 0.0941844111172376 no 3038 0.0952686347111909 994 5403748 SGTC_2134 5324836 1.464 µM -1.3100600760758 0.0940018036102004 no 3039 0.0950877565214655 1011 699272 SGTC_3094 9117742 49.47 µM -1.31067053705974 0.093897611432932 no 3040 0.0949845484313315 998 17149698 SGTC_1617 st002906 78 µM -1.31351278225684 0.0934136252086145 no 3041 0.0945051083004254 1003 5150859 SGTC_1919 st067113 52.3 µM -1.3136867922147 0.0933840542331698 no 3042 0.0944758137415796 996 1268243 SGTC_730 1436-0052 41.2 µM -1.31587660433913 0.0930125119356076 no 3043 0.0941077312089324 992 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2 SGTC_3348 9149464 3.537 µM -1.31641631375812 0.0929211082791613 no 3044 0.0940171749225296 981 1951442 SGTC_2195 6536160 144.242 µM -1.31679724820738 0.0928566342890098 no 3045 0.0939532977490831 994 3834386 SGTC_135 0933-0004 26.348 µM -1.31690912940747 0.092837704436274 no 3046 0.0939345429831804 969 21230617 YGL099W LSG1 SGTC_254 nsc-64875 3.808 µM -1.32036635775823 0.0922541607704899 no 3047 0.0933563651000088 1001 56993 SGTC_866 0495-0101 262 µM -1.32084460575578 0.0921736517834529 no 3048 0.0932765915914865 975 635694 SGTC_1399 3562-5772 25 µM -1.32145740564674 0.0920705681619496 no 3049 0.0931744479646559 986 23847490 SGTC_3147 9097027 49.47 µM -1.32224020612276 0.0919390116720803 no 3050 0.0930440883110587 1002 25236841 SGTC_853 0419-0306 21 µM -1.3231290106903 0.0917898090868351 no 3051 0.0928962392963551 999 762713 SGTC_1422 4031-0024 15.5 µM -1.32445349374308 0.0915678025673633 no 3052 0.0926762393295394 1011 782427 SGTC_2781 5567276 71.43 µM -1.32455018704329 0.0915516106779736 no 3053 0.0926601934350747 982 2853274 SGTC_11 0438-0307 1.3 µM -1.32828632746365 0.0909275947533454 no 3054 0.0920417674005072 1003 4011476 SGTC_1609 st001574 46.4 µM -1.32861848652367 0.0908722701438067 no 3055 0.0919869349313092 988 3960012 SGTC_522 1273-0010 11.6 µM -1.33017794709954 0.0906128593254662 no 3056 0.091729824164612 966 5705015 SGTC_2582 agaric acid 100 µM -1.33105295185289 0.0904675462921451 no 3057 0.091585794098111 977 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase. SGTC_3300 9124615 50.48 µM -1.33498378490933 0.08981688247309 no 3058 0.0909408267852192 992 24824903 SGTC_1474 0330-0125 5.35 µM -1.33792198449697 0.0893328039592722 no 3059 0.0904609348802116 1028 X1474 SGTC_2990 9074105 71.4286 µM -1.3380488733095 0.0893119423956164 no 3060 0.0904402527474815 1008 6502001 SGTC_2882 9058044 58.44 µM -1.34214919493603 0.0886397652207414 no 3061 0.0897738128169638 978 18076804 SGTC_1946 st076057 65.1 µM -1.34315114951206 0.0884760863567386 no 3062 0.0896115179730416 992 953009 SGTC_2178 5812956 200 µM -1.34347939510616 0.0884225132987833 no 3063 0.089558396799314 983 5403383 SGTC_2247 cerulenin 830 nM -1.34421009258596 0.0883033427490562 no 3064 0.0894402294698006 976 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12 SGTC_2971 9092186 9.93 µM -1.34588775352756 0.0880301834766341 no 3065 0.0891693594525793 994 25236400 SGTC_1269 0831-0796 3.05 µM -1.34721858053428 0.0878139447412667 no 3066 0.088954922740013 961 927758 SGTC_568 1193-0097 7.48 µM -1.35223848493423 0.0870018534918007 no 3067 0.0881495179930988 938 3646150 SGTC_895 0964-0006 13.7 µM -1.35675918840874 0.0862753325338666 no 3068 0.0874288694758995 1009 6738897 SGTC_1853 st056710 91.2 µM -1.36874342335258 0.0843713185100987 no 3069 0.0855397457843017 1006 269167 SGTC_1400 3771-8998 51.5 µM -1.36898213745229 0.0843337153309232 no 3070 0.0855024292908198 1015 670767 SGTC_1832 st054113 55 µM -1.36980005029309 0.0842049698658584 no 3071 0.0853746631859637 996 1251267 SGTC_2770 toltrazuril 17.5 µM -1.37031045902512 0.0841247025862868 no 3072 0.0852950047761025 976 68591 Kills coccidiodes. SGTC_776 4476-4378 112 µM -1.37038130094676 0.0841135664706812 no 3073 0.085283953029372 1023 2892008 SGTC_1809 st050081 57.6 µM -1.37827650122159 0.0828793897329707 no 3074 0.0840589677517195 1007 5036894 SGTC_1509 1326-1131 80 µM -1.37853685398526 0.0828389247031478 no 3075 0.0840187987145312 982 768313 SGTC_3100 9120536 49.47 µM -1.38133562330969 0.0824048675283985 no 3076 0.0835878949318663 992 16421196 SGTC_571 k831-0106 44.2 µM -1.38312438902321 0.0821283487474025 no 3077 0.0833133643103052 992 4783639 SGTC_1346 1488-2224 62.4 µM -1.38598655117134 0.0816873523623989 no 3078 0.0828755050790237 983 3722427 SGTC_963 1269-2853 151 µM -1.38917145405997 0.0811987297990109 no 3079 0.0823903099242545 1008 3668223 SGTC_2502 avocadyne acetate 18.59 µM -1.39182185782883 0.0807937930835595 no 3080 0.0819881746488872 990 3952079 SGTC_1859 st055998 20 µM -1.39379942667199 0.080492648773886 no 3081 0.0816890906730396 1011 676301 SGTC_2905 7799065 20.05 µM -1.39794304652595 0.0798644089729318 no 3082 0.0810650853265741 974 1296806 SGTC_2938 9059746 27.26 µM -1.40129116928577 0.0793594938180095 no 3083 0.0805635104066734 1015 6471769 SGTC_299 1273-0059 1.44 µM -1.40706585229181 0.0784943232463042 no 3084 0.0797039313374588 972 2848077 SGTC_764 1951-2361 146 µM -1.40749799393594 0.0784298679100602 no 3085 0.0796398858429005 997 5438930 SGTC_2194 5927483 104.545 µM -1.41310779064621 0.0775967861205899 no 3086 0.0788120164529139 1008 760979 SGTC_177 1327-0068 8.361 µM -1.41480335283415 0.0773463138983741 no 3087 0.0785630804004197 1002 15389900 YOR207C | YLR033W RET1 | RSC58 SGTC_227 fluconazole 33.516 µM -1.41803845961967 0.0768701211013565 no 3088 0.0780897682872337 1013 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C SGTC_1067 clotrimazole 1.36 µM -1.4190628922985 0.0767197949052197 no 3089 0.0779403405735773 992 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_2570 licareol 100 µM -1.42368733035969 0.0760439816384084 no 3090 0.0772685014484857 1006 443158 SGTC_671 0560-0003 407 µM -1.42594544285622 0.0757156334235929 no 3091 0.076942045381347 1019 3238678 SGTC_2356 9061756 188.97 µM -1.43043912033183 0.0750654301538676 no 3092 0.0762955135538953 1008 20104043 SGTC_1909 st060837 51.5 µM -1.43249953049599 0.0747687310074046 no 3093 0.0760004561908776 987 678937 SGTC_1106 tegaserod maleate 11.7 µM -1.43536946179214 0.0743569530735777 no 3094 0.0755909216987981 991 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation. SGTC_1587 estradiol valerate 56.1 µM -1.43550412757622 0.0743376738354655 no 3095 0.075571746492474 1027 13791 A steroid. SGTC_311 1315-0136 58 µM -1.43561267628189 0.0743221363907833 no 3096 0.075556292823069 1017 6759207 SGTC_1010 4112-3296 15.2 µM -1.4413421865277 0.0735055407329109 no 3097 0.0747440172948606 994 704384 SGTC_2956 9076196 2.52 µM -1.44505264000438 0.0729803818687123 no 3098 0.074221550160998 1032 16423868 SGTC_1861 st057647 17.4 µM -1.44542474551843 0.0729278747747571 no 3099 0.0741693084369157 1012 688668 SGTC_1124 fisetin 1.16336 µM -1.44899741602836 0.072425212792327 no 3100 0.0736691520967827 1017 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster. SGTC_156 3474-0145 5.642 µM -1.45020327059577 0.072256153856006 no 3101 0.0735009216519372 996 2265471 SGTC_738 1315-0003 72.4 µM -1.45125283291257 0.0721092531662191 no 3102 0.0733547350220149 1026 6251474 SGTC_2383 9036125 200 µM -1.45234706701625 0.0719563439209233 no 3103 0.0732025632558295 1022 79580 SGTC_111 0083-0039 52.457 µM -1.45439544803074 0.0716707698323269 no 3104 0.0729183506226934 1007 759313 SGTC_1048 3161-0300 24.5 µM -1.45439938717319 0.0716702214974546 no 3105 0.0729178048820409 1006 2165101 SGTC_331 k048-0133 24.5 µM -1.45474846124838 0.0716216426109669 no 3106 0.0728694555226948 1021 6813582 SGTC_140 0062-0056 502.533 µM -1.45690506627362 0.0713220786878168 no 3107 0.072571293685388 1018 3758964 SGTC_469 w7 172 µM -1.46033987881391 0.0708469519821573 no 3108 0.0720983435825353 1028 45115570 A P450 inhibitor. SGTC_356 1634-0012 32.5 µM -1.46164327657393 0.0706672948984584 no 3109 0.0719194943548646 1016 735457 SGTC_292 k038-0015 474 µM -1.46234629601196 0.0705705379182902 no 3110 0.0718231689923279 1020 46368540 SGTC_3203 9113543 49.47 µM -1.46377269815525 0.0703745342849978 no 3111 0.0716280322439307 1007 17018012 SGTC_2815 7968870 71.43 µM -1.46750758245116 0.0698633022404361 no 3112 0.0711190140591418 1024 2977326 YHR190W ERG9 SGTC_2411 st077133 39.94 µM -1.46752913564193 0.0698603603500094 no 3113 0.0711160847099813 1019 1403142 YNL221C POP1 SGTC_2853 9015042 58.44 µM -1.47174577992097 0.0692866436486161 no 3114 0.0705447700686257 1001 6457456 SGTC_497 capsazepine 133 µM -1.47215611293584 0.0692310080877964 no 3115 0.070489362802535 1016 2733484 A calcium channel blocker. SGTC_876 0720-0963 56.8 µM -1.47291640642218 0.0691280136356797 no 3116 0.0703867888012471 1026 765861 SGTC_510 ag-490 170 µM -1.47332012194201 0.0690733716395594 no 3117 0.0703323687194893 1032 5328779 SGTC_2592 piperlongumine 83.33 µM -1.47799233288752 0.0684434175521299 no 3118 0.0697049152214148 1024 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_1006 4099-6547 255 µM -1.47967746780461 0.0682173016520377 no 3119 0.0694796707875941 1028 3146833 SGTC_1330 1469-0054 61.8 µM -1.48278739015911 0.067801518366545 no 3120 0.0690654536877621 1014 7102664 SGTC_1749 st037932 54.2 µM -1.48646188260821 0.0673127801767286 no 3121 0.0685784959776578 1026 594497 SGTC_664 1222-0054 14.9 µM -1.48865325367403 0.0670226085771091 no 3122 0.0682893503004278 1021 6813991 SGTC_2739 tacrine 100.86 µM -1.49608732379507 0.0660454265435938 no 3123 0.0673154503904264 942 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders. SGTC_108 0509-0257 621.132 µM -1.49816898363592 0.0657737875208515 no 3124 0.0670446759390814 1024 536624 SGTC_974 1326-0144 138 µM -1.49843019862368 0.065739762413064 no 3125 0.0670107576484984 1027 5411856 SGTC_1155 4088-0394 48.2 µM -1.50101096156866 0.0654043326194199 no 3126 0.0666763632087312 1015 2326248 SGTC_2855 9016525 58.44 µM -1.50266400351111 0.0651901800649844 no 3127 0.0664628548103027 1014 43811474 SGTC_1776 st049249 45.9 µM -1.50528913399124 0.0648512114618716 no 3128 0.0661248787890329 1033 1822314 SGTC_1696 st025591 34.7925 µM -1.50669546508398 0.0646701834581011 no 3129 0.0659443672509927 1005 2787147 SGTC_1314 1222-0010 41.1 µM -1.51812584487778 0.063213348409673 no 3130 0.0644913384799382 1034 3526027 SGTC_2071 5230951 39.92 µM -1.51955957062013 0.0630324339943798 no 3131 0.0643108527452301 1041 1799272 SGTC_2788 5282734 71.43 µM -1.52152895839102 0.0627845849295899 no 3132 0.0640635749835792 1006 743706 SGTC_1602 st001878 87.6 µM -1.52603145753426 0.0622207948632545 no 3133 0.0635010152007216 1023 595405 YLR310C CDC25 SGTC_172 1112-0046 2.638 µM -1.52663707668475 0.0621452632241941 no 3134 0.0634256410291973 1042 2802135 YIL048W NEO1 SGTC_1724 st037281 8.293 µM -1.52842500940203 0.0619226930094667 no 3135 0.063203524661017 997 574124 YDL195W SEC31 SGTC_359 0081-0058 15.9 µM -1.53544868495441 0.0610543704054 no 3136 0.0623368263682903 1029 3494159 SGTC_526 4469-0568 170 µM -1.53780947752774 0.0607646572001646 no 3137 0.0620476027964442 1012 2901964 SGTC_107 0358-0022 2.6945 µM -1.53881714660536 0.0606413252989473 no 3138 0.0619244713198012 1047 521106 YGL093W | YPR107C SPC105 | YTH1 SGTC_2378 9074213 121.43 µM -1.54145736276324 0.0603191092133141 no 3139 0.0616027561608785 1016 657714 SGTC_2461 5755302 26.15 µM -1.54668024389565 0.0596856493617372 no 3140 0.0609701846499286 1046 2788904 SGTC_962 1254-0300 21.5 µM -1.54885014543484 0.0594240093452585 no 3141 0.0607088739126266 1012 7340576 SGTC_2927 9011802 47.9 µM -1.55021402609461 0.0592600175513436 no 3142 0.0605450772044335 1025 43912568 SGTC_1123 mangostin 811.285 nM -1.55058324726487 0.0592156838215158 no 3143 0.0605007947139453 990 5281650 An antioxidant. SGTC_3012 9080433 71.4286 µM -1.55749373735942 0.0583907061533536 no 3144 0.0596766531597218 1012 17688859 SGTC_3305 9127027 53.8275 µM -1.55936998269782 0.0581682843177199 no 3145 0.0594544183234997 1014 41905295 SGTC_1646 st011709 75.6 µM -1.559510598101 0.0581516417403318 no 3146 0.0594377890769595 1036 5757843 SGTC_3193 9111931 49.47 µM -1.56751768521944 0.057210117587829 no 3147 0.0584968678645929 1037 17087244 SGTC_2485 5633444 17.78 µM -1.56782014140957 0.0571747894214231 no 3148 0.0584615564948038 1027 5724239 SGTC_674 0498-0004 451 µM -1.56806496723447 0.0571462053029644 no 3149 0.0584329856557964 983 4231473 SGTC_2104 5389443 200 µM -1.56897336735998 0.0570402452637165 no 3150 0.0583270724149581 1045 2244536 SGTC_2516 gossypol 71.55 µM -1.57042742137051 0.0568709596189672 no 3151 0.058157853583959 1034 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_1988 st071872 53.4 µM -1.57159408961971 0.0567354186402248 no 3152 0.0580223590271478 1033 16414116 SGTC_794 k038-0031 316 µM -1.58261305574919 0.0554677765068384 no 3153 0.0567548429595173 1011 6624242 SGTC_3235 9132602 49.47 µM -1.5991602946548 0.0536062775294585 no 3154 0.0548924951030798 1030 4912240 SGTC_598 3937-0236 20.2 µM -1.60919914497065 0.0525012889456781 no 3155 0.0537864016630513 1036 1379313 SGTC_1186 1319-0216 26 µM -1.61107222107802 0.0522971327216709 no 3156 0.053581991091628 1029 4565136 SGTC_2968 9090663 33.37 µM -1.61215419206367 0.0521794906774862 no 3157 0.0534641952907386 999 25236811 SGTC_1606 st000094 49.2 µM -1.61896807420449 0.0514434440105763 no 3158 0.0527270662283208 1027 1242210 SGTC_2571 chrysanthemic acid 100 µM -1.62232607164243 0.0510837575469315 no 3159 0.0523667745798299 1046 2743 An insecticide. SGTC_780 0109-0199 192 µM -1.62544563554751 0.0507514065309335 no 3160 0.052033819363698 1021 610414 SGTC_1222 0366-0074 1.18 µM -1.62926110769012 0.0503472584998665 no 3161 0.0516288778426801 1048 286520 SGTC_484 loperamide 105 µM -1.63045014808241 0.0502218367279178 no 3162 0.0515031966167518 1042 3955 An opioid-receptor agonist. SGTC_3332 9141069 11.198 µM -1.63727986972861 0.0495062438474069 no 3163 0.05078600254559 1030 17332883 SGTC_2110 5483698 200 µM -1.64140639113417 0.0490778413998451 no 3164 0.0503565420451736 1035 2848765 YHR062C RPP1 SGTC_1080 nisoldipine 24.4 µM -1.64516942530611 0.048689761347384 no 3165 0.0499674383926726 1042 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class. SGTC_1094 duloxetine 25.4 µM -1.65686865639005 0.0474988734178268 no 3166 0.048773016265312 1038 60834 A selective serotonin reuptake inhibitor. SGTC_2128 5255449 168.493 µM -1.6593449482189 0.0472498237788787 no 3167 0.0485231513783265 1017 736008 SGTC_513 4245-1575 41.7 µM -1.66348052393505 0.0468362285238876 no 3168 0.0481081431243177 1011 719745 SGTC_212 3807-4682 38.772 µM -1.66361412228295 0.0468229160478328 no 3169 0.0480947839346184 1037 3125501 YBL034C STU1 SGTC_1516 st013856 110 µM -1.66447054483474 0.0467376494590883 no 3170 0.0480092163123953 1045 5281404 A mutagen and neurotoxin. SGTC_1662 st014054 52 µM -1.66670669324099 0.0465156026726909 no 3171 0.0477863706765361 1054 2838777 SGTC_2507 purpurin 79.67 µM -1.66687487402419 0.0464989368202068 no 3172 0.0477696439939832 1037 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1 SGTC_1469 k284-2957 126 µM -1.67685633060295 0.045518378128831 no 3173 0.0467852896567156 993 23884841 SGTC_1326 1431-2094 10.8 µM -1.67777280911916 0.0454291847929756 no 3174 0.0466957297210844 1034 616278 SGTC_2617 dihydrotanshinone i 20.83 µM -1.68305834571025 0.0449175263562606 no 3175 0.0461818985464657 1032 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12 SGTC_2923 7992654 58.14 µM -1.6880956309367 0.0444342267741 no 3176 0.0456964365090077 1025 2985126 SGTC_395 anisomycin 6.25 µM -1.69107375251492 0.0441504690846154 no 3177 0.0454113587519575 1050 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_2395 5646831 180.19 µM -1.69376818126481 0.0438950023172226 no 3178 0.0451546713113385 1057 6808628 SGTC_1987 st072290 61.9 µM -1.69650631304312 0.0436366147292679 no 3179 0.044895017813176 1045 54697379 SGTC_3123 9126162 49.47 µM -1.70030866333191 0.043279837858287 no 3180 0.0445364408723766 1028 25239884 SGTC_360 0957-0399 1.01 µM -1.70247144596082 0.0430779559293145 no 3181 0.0443335133865051 1042 6752301 YPR165W RHO1 SGTC_1571 st070080 73.4 µM -1.70499593979188 0.0428432735082392 no 3182 0.0440975908342882 1034 4315245 SGTC_849 0386-0493 241 µM -1.71462891691186 0.0419572488522988 no 3183 0.0432066417858308 1048 726119 SGTC_3264 9137442 49.47 µM -1.71479547151211 0.0419420609055522 no 3184 0.0431913660496408 1020 17015726 SGTC_530 4358-1714 28 µM -1.71587489737927 0.0418437370121943 no 3185 0.0430924710440384 1032 1564641 SGTC_3294 9122953 26.2835 µM -1.71734885923671 0.0417097767326488 no 3186 0.0429577248899687 1047 16459826 SGTC_2811 7967822 32.47 µM -1.72503696266279 0.0410166681030452 no 3187 0.042260405748184 1026 2232244 SGTC_3283 9109332 35.8195 µM -1.72547572404914 0.040977395736504 no 3188 0.042220887502404 1019 17027281 SGTC_482 fipronil 114 µM -1.72618493871225 0.040913980312458 no 3189 0.0421570733754501 1061 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels. SGTC_149 3970-0822 46.1 µM -1.73105732320661 0.0404804585082708 no 3190 0.0417207705082748 1030 3114250 YBL034C STU1 SGTC_2092 5303694 80.6725 µM -1.73671986458455 0.0399813257927069 no 3191 0.0412183148486764 1047 1963699 SGTC_1492 4158-0558 28.5 µM -1.73938575894147 0.0397480744681573 no 3192 0.0409834657555725 1026 3967268 SGTC_2489 cantharidin 73.42 µM -1.73950277411643 0.0397378616742362 no 3193 0.0409731823455774 1038 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_1550 gossypolone 36.6 µM -1.74232635386578 0.0394920728300511 no 3194 0.0407256772536066 1047 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_226 1,3-diallylurea 8.28947 mM -1.7437259624327 0.0393706979835449 no 3195 0.0406034429871164 1043 74537 YKL182W FAS1 SGTC_2703 st077852 53.4 µM -1.74584989832211 0.0391870889885928 no 3196 0.0404185188653992 1029 6281836 SGTC_1998 st075797 76.8 µM -1.74903684181878 0.0389128936408339 no 3197 0.0401423256283467 1042 24208315 SGTC_1663 st014140 55.4 µM -1.75543305640113 0.0383672965281992 no 3198 0.0395926309683767 1036 4207120 SGTC_261 5-fluorouridine 15.376 µM -1.76034834277188 0.0379522738203871 no 3199 0.0391743811060946 1049 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_2241 6772625 37.8075 µM -1.77242176720209 0.0369483864262963 no 3200 0.0381622855683428 1028 2285411 SGTC_1515 3460-0031 42.1 µM -1.77250239243267 0.0369417562465572 no 3201 0.0381555992580907 1044 2876596 SGTC_969 1313-0238 134 µM -1.77263342091577 0.036930983252749 no 3202 0.0381447350067663 1033 5212874 SGTC_732 3970-1727 52.7 µM -1.7746914744957 0.0367621094712887 no 3203 0.0379744218983321 1055 1275699 SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM -1.77884839990639 0.036422938501185 no 3204 0.0376323098497181 1052 5393153 SGTC_2047 4141938 200 µM -1.78950935457643 0.0355647855451608 no 3205 0.0367664111532431 1064 3807862 SGTC_765 1319-0117 244 µM -1.7910642449445 0.0354410210411596 no 3206 0.0366414930191466 1031 3487746 YGL099W LSG1 SGTC_2315 7733312 200 µM -1.79215229187652 0.0353546260475764 no 3207 0.0365542872015179 1043 726316 SGTC_1350 1495-0454 146 µM -1.79761129044416 0.0349237647238706 no 3208 0.0361193139481819 1056 1069057 SGTC_1700 st030840 7.9285 µM -1.79860483653451 0.0348458128170049 no 3209 0.0360406058769219 1063 5499307 SGTC_2748 diazoxide 86.69 µM -1.80336753657366 0.0344741207748625 no 3210 0.0356652562287437 1052 3019 A potassium channel activatior. SGTC_210 3551-0445 56.827 µM -1.80570486469651 0.0342929054027235 no 3211 0.0354822261948829 1053 2865180 YOR207C RET1 SGTC_1254 0550-0035 264 µM -1.80583512408223 0.0342828293383038 no 3212 0.0354720486219311 1054 15121435 SGTC_878 0828-0289 13.7 µM -1.8133012385393 0.0337093508332324 no 3213 0.0348926861932312 1033 745350 YLR208W SEC13 SGTC_2174 5790901 200 µM -1.81597263363807 0.0335060859783162 no 3214 0.0346872850902264 1053 786020 SGTC_1531 st059297 52.4 µM -1.82225453508144 0.0330320739127815 no 3215 0.0342081866259208 1052 7566702 SGTC_1200 1643-0193 18.4 µM -1.82387216530237 0.032910911476941 no 3216 0.0340857003168086 1054 5403974 SGTC_820 1582-0060 59.9 µM -1.82605264757239 0.0327481706440294 no 3217 0.0339211659620166 1050 3848840 SGTC_3197 9113331 49.47 µM -1.83210675769906 0.0322997962821426 no 3218 0.033467758384913 1027 16610459 YLR208W | YDL195W SEC13 | SEC31 SGTC_120 rhodamine 6G 52.259 µM -1.83621630620044 0.0319983345064862 no 3219 0.0331628359856657 1056 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase SGTC_896 0964-0007 44.5 µM -1.83624456834816 0.0319962693684518 no 3220 0.0331607469266545 1041 6756758 SGTC_475 α-linolenic acid 10 µM -1.83640074518041 0.0319848593852476 no 3221 0.0331492047261869 1039 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_1032 k061-1018 98.7 µM -1.860008443496 0.0302983667463432 no 3222 0.0314421656892135 1065 4005393 SGTC_2313 7726885 200 µM -1.86129568869938 0.0302085680698211 no 3223 0.0313512158357396 1048 726423 SGTC_264 promethazine 12.5 mM -1.86466516323351 0.0299745563717819 no 3224 0.0311141763607494 1046 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3 SGTC_2652 actinonin 100 µM -1.86667909440428 0.0298354070348999 no 3225 0.0309732074271229 1072 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase. SGTC_3059 1327-0034 3 µM -1.87364880083713 0.0293579763752542 no 3226 0.0304894235314175 1047 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_2705 st078069 42.8 µM -1.87788120153778 0.0290711617500414 no 3227 0.0301987092804527 1061 1530061 SGTC_2533 agelasine 13.65 µM -1.87977493169036 0.0289435864303764 no 3228 0.0300693791635143 1046 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase. SGTC_2424 5537928 59.2 µM -1.88284214034555 0.028737944466864 no 3229 0.0298608821427 1032 5382802 SGTC_130 0136-0219 337.655 µM -1.88351973440745 0.0286926791767085 no 3230 0.029814983999002 1052 234244 SGTC_663 1486-0733 13.9 µM -1.88442255286527 0.0286324603694144 no 3231 0.0297539207981007 1062 722445 YPR165W RHO1 SGTC_2506 ethyl hematommate 54.16 µM -1.88547796831515 0.0285621965044846 no 3232 0.0296826681059798 1056 3940691 An allergen. SGTC_2259 7964009 200 µM -1.88570409992477 0.0285471605544068 no 3233 0.0296674200522368 1056 313134 SGTC_1429 4049-0205 9.46 µM -1.88780695605288 0.0284076524349806 no 3234 0.0295259355073193 1053 22774478 SGTC_1476 4112-3294 3.34 µM -1.8976936290453 0.0277593306326838 no 3235 0.0288682261572535 1013 704369 SGTC_1954 st077032 68.9 µM -1.89773901151579 0.0277563833302969 no 3236 0.0288652354085192 1054 698907 SGTC_2065 5221596 34.26 µM -1.89890652447917 0.0276806503937648 no 3237 0.0287883836738453 1050 788581 SGTC_145 3737-0113 38.366 µM -1.9101466348575 0.0269603112255859 no 3238 0.0280571679719915 1050 6849351 SGTC_1923 st058458 19.1 µM -1.91560024895881 0.0266164860478883 no 3239 0.0277079989301896 1055 3534982 SGTC_2069 5228469 200 µM -1.91883261314861 0.0264144347650965 no 3240 0.027502760514718 1063 2835210 SGTC_400 oxethazaine 37.5 µM -1.93245081006907 0.02557720112093 no 3241 0.0266519439282675 1063 4621 A local anesthetic. SGTC_1757 st041620 31.8375 µM -1.93716202887405 0.0252927823627565 no 3242 0.0263627701007032 1068 5289815 SGTC_1451 4152-0210 104 µM -1.94068778335445 0.0250816684153111 no 3243 0.0261480795419854 1053 659563 SGTC_2711 st079103 59.1 µM -1.94241859068666 0.0249785734437697 no 3244 0.0260432232601505 1063 54693780 SGTC_949 1165-0505 146 µM -1.95131904371812 0.0244540159357733 no 3245 0.0255095525303279 1054 6244267 SGTC_3275 9138069 49.47 µM -1.95288860779639 0.0243624778998795 no 3246 0.0254163979483879 1067 17617007 SGTC_2727 riluzole 51.77 µM -1.95526881443882 0.0242242116877087 no 3247 0.025275675019341 1069 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.  SGTC_1767 st044992 70.3 µM -1.9574466740268 0.0240982777909317 no 3248 0.0251474877742925 1063 9600693 SGTC_2027 5150920 200 µM -1.96258355620233 0.0238034167459646 no 3249 0.0248472914847506 1048 786715 SGTC_3229 9132204 49.47 µM -1.96523757322012 0.02365226623766 no 3250 0.0246933735484534 1080 17682924 SGTC_871 0574-0004 149 µM -1.98342905836457 0.0226378120657487 no 3251 0.0236597619867095 1070 9551173 SGTC_2188 6126565 140.678 µM -1.98876151041045 0.0223474906651501 no 3252 0.0233637665097486 1060 874518 SGTC_3112 9123419 49.47 µM -1.99267567662969 0.0221363910515667 no 3253 0.023148486249809 1074 17015854 SGTC_2856 9022925 19.48 µM -1.99873272865995 0.0218130393094767 no 3254 0.0228186399158475 1059 4944862 SGTC_2964 9083345 53.42 µM -1.99992600423018 0.0217498097097782 no 3255 0.0227541273469413 1053 17741579 SGTC_1544 7-methoxy-4-methylcoumarin 105 µM -2.00988000057429 0.0212283727161192 no 3256 0.0222219454722527 1073 390807 SGTC_202 3594-0513 34.79 µM -2.01261030718378 0.0210872081617932 no 3257 0.0220778208912843 1079 708429 SGTC_346 4513-0042 7.16 µM -2.02849509447027 0.0202815801851137 no 3258 0.0212548717326972 1051 2827372 SGTC_757 1066-0008 322 µM -2.02886242995615 0.0202632630841728 no 3259 0.0212361521854522 1049 6842497 SGTC_2713 st079149 53.4 µM -2.03441602396191 0.0199880387845271 no 3260 0.0209548337985153 1065 3103253 SGTC_540 1187-0821 17.3 µM -2.03451637646821 0.0199830948437196 no 3261 0.0209497795753775 1065 847520 SGTC_670 4204-0025 119 µM -2.03783116455807 0.0198203714685714 no 3262 0.0207834102662226 1063 719039 SGTC_2626 ethyl orsellinate 100 µM -2.0467004616471 0.0193904971765357 no 3263 0.0203437519547609 1066 75653 A natural product. SGTC_1585 2',4'-dihydroxychalcone 10.4 µM -2.04743524597939 0.0193552419129561 no 3264 0.0203076843470135 1064 5357218 A potent inhibitor of glutathione S-transferases. SGTC_685 1278-0033 54.9 µM -2.05053696712016 0.0192070196447427 no 3265 0.0201560301120619 1074 3590572 SGTC_843 0310-0051 143 µM -2.05314894348685 0.0190829502740673 no 3266 0.0200290671933626 1072 2065037 SGTC_1487 3970-0795 2.82 µM -2.05440367204992 0.0190235931438841 no 3267 0.0199683189807071 1069 3765103 SGTC_2536 dehydroabietamide 32.04 µM -2.05507851261739 0.0189917336129737 no 3268 0.0199357109852965 1067 3983547 SGTC_2335 9018011 154.17 µM -2.05896228628979 0.018809259651533 no 3269 0.0197489257296046 1054 6458208 SGTC_2402 5553605 200 µM -2.06343904577683 0.0186007779095158 no 3270 0.0195354667200363 1072 6758546 SGTC_646 4092-0839 27.3 µM -2.07043026018129 0.018279134618169 no 3271 0.0192060352812974 1067 877796 SGTC_1087 pterostilbene 9.05 µM -2.0788050528343 0.0179000870018118 no 3272 0.0188176361458081 1080 5281727 Similar to reservatol, lowers cholesterol. SGTC_1637 st007924 17.4 µM -2.07915719765075 0.0178842967029992 no 3273 0.0188014521518627 1049 683336 SGTC_2961 9083290 32.55 µM -2.07937162178597 0.0178746876690617 no 3274 0.0187916033754615 1074 17741490 SGTC_307 1501-1223 22.3 µM -2.09242606141096 0.0172979132966908 no 3275 0.018200209750206 1074 2830329 SGTC_1221 2958-7315 257 µM -2.09329205759516 0.0172602204277849 no 3276 0.0181615456102919 1071 4562705 SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM -2.11136917684332 0.0164892773303782 no 3277 0.0173702961394169 1057 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_3268 9137683 49.47 µM -2.11713457071415 0.016249681468745 no 3278 0.0171242142089139 1085 1953228 SGTC_2869 9037858 32.47 µM -2.12311852405798 0.0160041628883561 no 3279 0.0168719605622893 1079 27187042 SGTC_1389 3405-0187 19 µM -2.12930765710153 0.0157535778638302 no 3280 0.0166144073544478 1058 799890 SGTC_1564 D-Arginine 115 µM -2.13838590570742 0.0153921107272597 no 3281 0.0162427177187272 1070 71070 D-isomer of arginine; arginine decarboxylase inhibitor. SGTC_644 1498-1197 63.3 µM -2.14106744774836 0.0152867120764006 no 3282 0.0161342996555255 1079 6741615 SGTC_322 k048-0136 19.3 µM -2.14840370195254 0.015001521091241 no 3283 0.0158408494810607 1081 6823282 SGTC_1695 st026914 34.495 µM -2.14923969566809 0.0149693146306479 no 3284 0.0158077020466179 1081 3289191 SGTC_1567 st069303 68.4 µM -2.15770129540127 0.0146466650955843 no 3285 0.0154755315905276 1078 5581319 SGTC_983 1491-0821 12.2 µM -2.16804685509655 0.0142603241117061 no 3286 0.0150775608731337 1072 46495113 SGTC_1153 4055-0057 267 µM -2.20927242311496 0.0128067397611383 no 3287 0.0135778490545215 1066 882706 SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM -2.21281848225052 0.0126879173715176 no 3288 0.0134550812662856 1077 688798 SGTC_1183 1254-0324 198 µM -2.21976022805376 0.0124580708328337 no 3289 0.0132175240163223 1069 5799357 SGTC_3266 9136860 49.47 µM -2.22799625935828 0.0121900539543923 no 3290 0.0129403822225461 1044 4871271 YPR165W RHO1 SGTC_1495 4469-0029 237 µM -2.22947672139701 0.0121424103678326 no 3291 0.0128911012446011 1078 793680 SGTC_3223 9129970 49.47 µM -2.23341458144702 0.0120164687322312 no 3292 0.0127608087462282 1079 17248386 SGTC_1807 st050092 58.9 µM -2.23382478546691 0.0120034148584538 no 3293 0.0127473020214244 1081 5008496 SGTC_2844 9010103 25.97 µM -2.23604527409331 0.0119329657572987 no 3294 0.0126744028300662 1063 2480525 SGTC_1893 st059353 36.1 µM -2.23841919671768 0.011858045611728 no 3295 0.0125968656664925 1076 3112488 SGTC_1804 st050076 49.1 µM -2.24532727212254 0.0116423462869054 no 3296 0.0123735652492838 1078 3895976 SGTC_352 k048-0007 5.11 µM -2.26215240238838 0.0111311927929912 no 3297 0.0118439944572347 1063 6811911 SGTC_2864 9034755 47.6 µM -2.26873603403301 0.0109365568196086 no 3298 0.0116421914579532 1072 4930451 SGTC_2725 haloperidol 53.21 µM -2.27063168802046 0.0108810663994243 no 3299 0.0115846417624601 1069 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_3129 9127257 49.47 µM -2.28448911154025 0.0104828172419896 no 3300 0.0111714008920499 1072 837894 SGTC_634 1611-4317 11.2 µM -2.30486678067781 0.00992026933116352 no 3301 0.0105870177933406 1081 2843522 SGTC_163 TUB2.036 7.546 µM -2.31002936533545 0.00978200523585525 no 3302 0.0104432642110158 1055 15992207 YJR013W GPI14 SGTC_861 0443-0273 110 µM -2.31169487767819 0.00973776013790921 no 3303 0.0103972519380479 1079 6149169 SGTC_1178 0988-0033 191 µM -2.32010075306336 0.0095171120976933 no 3304 0.0101677138083133 1073 5392207 SGTC_319 1348-1596 45.5 µM -2.35491837475429 0.00864906619573979 no 3305 0.00926338741667679 1078 5380505 SGTC_2795 7780010 54.55 µM -2.36070751994969 0.00851167658468639 no 3306 0.00912005495894642 1063 953673 SGTC_2307 7538926 6.34 µM -2.37181592506541 0.00825340313382747 no 3307 0.00885045339983017 1063 96582 SGTC_1115 galangin 695.678 nM -2.37198929165646 0.00824942747085481 no 3308 0.00884630173732874 1089 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_1358 1509-0022 2.48 µM -2.37774351587597 0.00811842186941136 no 3309 0.00870946860635951 1081 3258434 SGTC_1591 genipin 88.4 µM -2.37965586724961 0.00807529023714737 no 3310 0.00866440635421204 1077 442424 A DNA cross-linking agent. SGTC_223 busulfan 5 mM -2.40738171817831 0.00747220649932282 no 3311 0.00803368301263844 1078 2478 A DNA alkylator. SGTC_595 3909-8003 73.7 µM -2.40921270028657 0.00743381394988911 no 3312 0.00799348883355018 1089 699517 SGTC_2720 fluspirilene 36.88 µM -2.4218014561879 0.00717452333853421 no 3313 0.00772189288628682 1081 3396 An atypical antipsychotic. SGTC_1529 apigenin 74 µM -2.4280349838428 0.00704910965028354 no 3314 0.00759043942670778 1074 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_3187 9109394 49.47 µM -2.44575690783361 0.006703065208184 no 3315 0.00722742123050449 1079 17098090 SGTC_1402 3909-7673 35.9 µM -2.46036084980667 0.00642927675755188 no 3316 0.00693986917927212 1088 5328014 SGTC_2508 celastrol 40.54 µM -2.4660440497164 0.00632543474068164 no 3317 0.00683072662669727 1072 122724 Celastrol is a natural product and antioxidant. SGTC_474 dl-dihydrosphingosine 5 µM -2.4798974050495 0.00607850569644351 no 3318 0.00657100951466695 1071 3058739 A sphingolipid protein kinase C inhibitor. SGTC_1701 st028638 40.4 µM -2.48355743800629 0.0060147108501805 no 3319 0.00650386774964507 1086 3490878 SGTC_343 4130-2827 29.8 µM -2.5007388677641 0.00572310174617058 no 3320 0.0061967261848315 1084 1118244 SGTC_282 k297-0036 65.7 µM -2.52224333319373 0.00537584515657209 no 3321 0.00583045066230182 1078 5061378 SGTC_2857 9024691 58.44 µM -2.53003936440174 0.00525465868248745 no 3322 0.00570248651809357 1080 16478292 SGTC_3259 9138485 49.47 µM -2.53046257184026 0.00524815017132466 no 3323 0.00569561188012187 1082 17646153 SGTC_756 0508-1999 28.3 µM -2.55181657736995 0.00492891608014705 no 3324 0.00535814593701965 1085 6753853 SGTC_1963 st076565 50.3 µM -2.56405990633799 0.00475379228865356 no 3325 0.0051727843288427 1089 4914280 SGTC_96 0929-0093 37.281 µM -2.58168514004964 0.0045114301794523 no 3326 0.00491596198380723 1086 6991579 SGTC_1524 corynanthine 62.1 µM -2.60638149483445 0.00419039868448236 no 3327 0.00457522408562633 1075 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist. SGTC_1211 1056-0033 32.3 µM -2.63838017574125 0.00380489596654957 no 3328 0.00416515669925912 1075 6741922 SGTC_1666 st014829 29 µM -2.68829872459832 0.00326673057867453 no 3329 0.00359085585276163 1093 3858230 SGTC_3267 9137951 49.47 µM -2.69617158836963 0.00318840765532686 no 3330 0.00350707623996358 1094 16643986 SGTC_3291 9121177 71.43 µM -2.7165510497374 0.00299345272123637 no 3331 0.00329830105801811 1085 17015612 SGTC_342 k048-0088 23.3 µM -2.72239168845121 0.00293959545546903 no 3332 0.00324056373951891 1088 6820570 SGTC_408 cantharidin 100 µM -2.72334236192202 0.00293091230257359 no 3333 0.00323125242812529 1091 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_1592 4',5'-dihydroxyflavone 8.85 µM -2.75884123036679 0.0026227755256103 no 3334 0.00290033548653413 1056 688669 SGTC_1992 st073643 23.3 µM -2.83710677237115 0.00204433118656134 no 3335 0.00227621926013093 1093 3161292 SGTC_3130 9127414 49.47 µM -2.83954290418405 0.00202834653888537 no 3336 0.00225891096272105 1089 1494646 SGTC_3047 9092122 49.47 µM -2.84658250299828 0.00198279181155596 no 3337 0.00220956382401608 1088 17173831 SGTC_1279 0874-0590 65.2 µM -2.84819119501665 0.00197251291655613 no 3338 0.00219842504064267 1093 3523074 SGTC_2712 st079126 47.7 µM -2.85115615556117 0.00195369470931437 no 3339 0.00217802854606883 1087 3152970 SGTC_2721 ifenprodil 61.44 µM -2.87781706738653 0.00179166576955087 no 3340 0.00200218636947888 1082 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor. SGTC_2887 9044784 58.44 µM -3.01185493608083 0.00114742925247731 no 3341 0.00129828324695553 1085 6465546 SGTC_2992 9074591 71.4286 µM -3.04591488702652 0.00102176241015281 no 3342 0.00115986745609596 1090 17741321 SGTC_966 1300-0360 30.2 µM -3.0586981712079 0.000977951575673804 yes 3343 0.00111150498166979 1060 70588 SGTC_692 k241-0027 77.8 µM -3.06763926151164 0.000948340983580175 yes 3344 0.00107878451035267 1087 3600480 SGTC_1976 st070609 63.5 µM -3.1464110751816 0.000720897093745013 yes 3345 0.000826437574714708 1093 682556 SGTC_1977 st070720 65.3 µM -3.36367166166541 0.000327984534491296 yes 3346 0.000384564936575246 1092 682188 SGTC_1962 st076595 64.5 µM -3.45592513183689 0.000231517883931419 yes 3347 0.000274203810648452 1089 279619 SGTC_564 3555-0129 330 µM -3.46085077093264 0.000227198988326352 yes 3348 0.000269235607443814 1094 563260 SGTC_399 oxolinic acid 75 µM -3.48360563191575 0.000208205515777267 yes 3349 0.000247353928421681 1092 4628 A DNA gyrase inhibitor. SGTC_2729 fluphenazine 10.66 µM -3.60393674315674 0.000130117577741073 yes 3350 0.00015671668502582 1093 3372 An atypical antipsychotic. SGTC_708 3448-5400 146 µM -3.60630826690627 0.000128899269438313 yes 3351 0.000155292075014762 1093 3462195 SGTC_1723 st034307 2.5525 µM -3.96738908660517 2.88514828713497e-05 yes 3352 3.63321551333557e-05 1092 867466 SGTC_2406 ethylparaben 405.7 µM -4.31345374797503 6.08970808978554e-06 yes 3353 8.03618882160987e-06 1093 8434 A possible steroid mimic. SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM -4.42109301989551 3.66383092907208e-06 yes 3354 4.91014422008637e-06 1095 6312947 SGTC_2794 7785382 27.27 µM -4.96571547042119 2.34673189916923e-07 yes 3355 3.42241239247976e-07 1094 2205081 SGTC_372 0155-0182 15.9 µM -6.77591101285195 2.96229316859901e-12 yes 3356 6.18123782675288e-12 1056 771486