SGTCid condition conc unit SRM1|YGL097W.score SRM1|YGL097W.strain.pval SRM1|YGL097W.strain.significant SRM1|YGL097W.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene SGTC_1557 sumaresinolic acid 42.3 µM 10.3040803852354 8.21800829719092e-27 yes 1 3.3767244377136e-25 1 9982268 A natural terpine and antifungal of unknown mechanisn. SGTC_2830 7992007 71.43 µM 4.80787127008695 3.25301277534559e-07 yes 2 7.62729692660178e-07 5 1952075 SGTC_503 tyrphostin 8 294 µM 4.36782183356664 3.08035919488819e-06 yes 3 6.27458985114278e-06 7 92970 A tyrosine kinase inhibitor. YOR207C RET1 SGTC_2789 5281112 71.43 µM 4.31597297281422 3.96222226930892e-06 yes 4 7.9450711065372e-06 5 765948 SGTC_3275 9138069 49.47 µM 3.63018179613648 8.5468014764827e-05 yes 5 0.000141610834369209 3 17617007 SGTC_2874 9043904 71.43 µM 3.4979889814489 0.000146231135262001 yes 6 0.000234390249725719 4 4463428 SGTC_2942 9052777 62.25 µM 3.48290297549665 0.000155299212585316 yes 7 0.000248004046977434 11 6469503 SGTC_2826 7992541 19.48 µM 3.45836166054566 0.00017118365873097 yes 8 0.000271735649028892 5 2985066 SGTC_3273 9137859 49.47 µM 3.44806499384677 0.000178290562131527 yes 9 0.000282309077281265 6 2377234 SGTC_1119 parthenolide 318.541 nM 3.39546313779728 0.00021910539397483 yes 10 0.000342562994354633 13 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs. SGTC_2301 7769476 200 µM 3.3834880651799 0.000229543268377643 yes 11 0.00035785659061067 20 977820 SGTC_448 monastrol 171 µM 3.36272091269696 0.000248752002831444 yes 12 0.000385891732934276 3 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity SGTC_2979 9012552 45.46 µM 3.30103548860055 0.00031501111082007 yes 13 0.000481643486285881 4 17100905 SGTC_3207 9114163 49.47 µM 3.2807340188118 0.000340185703200982 yes 14 0.000517686663990421 20 849233 SGTC_816 0325-0417 81.3 µM 3.25196621180134 0.000379073205592471 yes 15 0.000573048226555214 12 68101 SGTC_1929 genistein trimethyl ether 50.5 µM 3.22654872020174 0.000416826635463234 yes 16 0.000626464496210116 10 136420 SGTC_2722 naftopidil 47.16 µM 3.19705586884553 0.000464992770629954 yes 17 0.000694190164224963 6 4418 An a1-adrenergic receptor antagonist or alpha blocker.  SGTC_2947 9072639 7.68 µM 3.1968528406204 0.000465341530376314 yes 18 0.000694678939682971 17 16488146 SGTC_2800 7887935 81.82 µM 3.15000793721654 0.000552613398909902 yes 19 0.000816330134471722 18 2961002 SGTC_1447 4239-0816 81.9 µM 3.06169378896487 0.000759558678612715 yes 20 0.00110044237527153 17 1341554 SGTC_2945 9067681 61.76 µM 3.04688502764243 0.000800559819286353 yes 21 0.00115613066791491 15 16456930 SGTC_2056 5235370 200 µM 3.03204730556671 0.000843675829323267 yes 22 0.00121450567015055 16 5511916 SGTC_392 N-ethylmaleimide 8.33 µM 3.00675420154739 0.000922127230424404 yes 23 0.0013202658867245 23 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides. SGTC_2521 angolensin 13.4 µM 2.99955968192607 0.000945636474709236 yes 24 0.00135185074396155 7 821428 A flavenoid. SGTC_2810 7959871 45.46 µM 2.99243150996056 0.000969470667224156 yes 25 0.00138382380294923 27 2974535 SGTC_2877 9040724 71.43 µM 2.97595154405165 0.00102670049014023 no 26 0.00146040504179295 11 6463895 SGTC_2591 skatole 100 µM 2.96247881748181 0.00107577208211091 no 27 0.00152586403263419 19 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite. SGTC_2788 5282734 71.43 µM 2.95324504261394 0.00111063622705949 no 28 0.00157226120972714 23 743706 SGTC_523 1934-0222 13.7 µM 2.92240278785478 0.00123472817203954 no 29 0.0017367101518597 17 1361595 SGTC_3288 9119690 36.221 µM 2.82321534564851 0.00172474026315545 no 30 0.00237723124422598 28 17595618 YKL019W RAM2 SGTC_2003 4023581 200 µM 2.80893707674728 0.00180829833226002 no 31 0.0024852680242092 25 16641307 SGTC_2568 diosmetin 100 µM 2.80718233237462 0.00181881742758969 no 32 0.00249884725077568 26 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.  SGTC_741 4582-0002 126 µM 2.73339862354725 0.00231479734545133 no 33 0.0031342208363924 10 2912688 SGTC_639 0833-0042 114 µM 2.73243722839789 0.00232199942506984 no 34 0.00314338249314876 20 5978911 YPR085C | YHR062C ASA1 | RPP1 SGTC_1879 gemcitabine 100 µM 2.70434168001337 0.00254163941958443 no 35 0.00342199373568129 12 60750 A nucleoside analog which inhibits DNA replication. SGTC_499 genistein 192 µM 2.69501556334309 0.00261859657492828 no 36 0.00351926716896694 7 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger. SGTC_3072 9116419 49.47 µM 2.67212543255559 0.00281648168907117 no 37 0.00376862343644156 19 17170162 SGTC_1732 st034308 51.822 µM 2.65803196956336 0.00294493188363492 no 38 0.00392992183899861 33 830119 SGTC_2247 cerulenin 830 nM 2.65577082352446 0.00296602491249324 no 39 0.00395636843098746 21 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12 SGTC_2294 7971431 200 µM 2.63695582231285 0.00314688881929627 no 40 0.00418268626610128 20 5741572 SGTC_1975 st070967 30.8 µM 2.60680309762795 0.00345751018387927 no 41 0.00456959490759519 42 261391 SGTC_2039 Aminomethylbenzodioxan 200 µM 2.60567519771421 0.0034696461752032 no 42 0.00458466833208315 19 15053 SGTC_1254 0550-0035 264 µM 2.55510377321395 0.0040546878449963 no 43 0.00530780721149503 31 15121435 SGTC_2987 9018338 71.43 µM 2.5528796965875 0.00408233449711865 no 44 0.00534181953187977 34 5055682 SGTC_789 1309-1135 70.6 µM 2.54630006867656 0.00416511387964673 no 45 0.00544357785064414 19 3092424 SGTC_2013 4024628 200 µM 2.53500935724819 0.00431066896112997 no 46 0.00562221612099204 31 5230760 SGTC_3063 1327-0034 4 µM 2.52122145052587 0.00449457260074205 no 47 0.00584741132204679 27 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_1262 0737-0114 49.6 µM 2.47257213022979 0.00520070393634686 no 48 0.00670723201481123 26 765919 SGTC_521 r062-0005 13.8 µM 2.47042070611325 0.00523409427278633 no 49 0.00674771170862636 17 2832033 SGTC_1753 st043925 64 µM 2.4685330410797 0.00526354798147266 no 50 0.0067834063337761 27 670181 SGTC_443 clozapine 122 µM 2.45985810585662 0.00540080927565506 no 51 0.00694959781033014 19 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_2850 9015429 58.44 µM 2.45573139810513 0.00546721500529309 no 52 0.00702991010637676 32 6457570 SGTC_1841 st054148 70 µM 2.41153203590616 0.0062252748239669 no 53 0.00794282810015811 24 675442 SGTC_1466 k213-0079 57.5 µM 2.40875589141843 0.0062758555927267 no 54 0.00800350022822232 50 3657981 SGTC_2359 9039622 200 µM 2.39882519112381 0.00645978244027288 no 55 0.00822388233645252 22 6463596 SGTC_1091 telmisartan 47.6 µM 2.39879320880765 0.00646038240930546 no 56 0.00822460061474437 12 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension. SGTC_2952 9073731 13.78 µM 2.38665066239525 0.0066917627851096 no 57 0.00850131950675662 41 16457353 SGTC_1880 MG-132 525 µM 2.38511189340892 0.00672160134827175 no 58 0.00853696366288101 40 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1 SGTC_373 0844-0104 25.9 µM 2.37478466737011 0.00692491863210975 no 59 0.00877959527077743 52 5375804 SGTC_1552 6-methylflavone 10.6 µM 2.37162817226756 0.00698813635022585 no 60 0.00885495149912258 33 689013 SGTC_3120 9124077 49.47 µM 2.36843869330896 0.00705253157162684 no 61 0.00893167031791522 25 18774327 YGL155W CDC43 SGTC_424 splitomicin 100 mM 2.36191940001902 0.00718578656061145 no 62 0.00909029721711741 36 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_493 zm226600 134 µM 2.35280298573813 0.00737584947389333 no 63 0.00931625161180183 36 5240098 A potassium channel opener. YCR052W RSC6 SGTC_3324 9138759 60.749 µM 2.30957497643064 0.00833866792022889 no 64 0.010455848157583 28 45595710 SGTC_1954 st077032 68.9 µM 2.27752306403207 0.00912216571896108 no 65 0.0113775044703015 31 698907 SGTC_3137 9097352 49.47 µM 2.27143829682094 0.00927797689558443 no 66 0.0115602291377641 48 44120435 SGTC_904 1141-0088 396 µM 2.26979948846431 0.00932033751965677 no 67 0.0116098758167087 34 1378119 SGTC_2355 9061122 103.12 µM 2.26591147483139 0.009421514146117 no 68 0.0117284019541731 30 5302957 SGTC_1568 digitonin 820 nM 2.25527918017974 0.00970311572935267 no 69 0.0120579053050079 64 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1 SGTC_1626 st003712 1.76 µM 2.24649066439665 0.00994140818277921 no 70 0.0123362984236139 43 24207035 SGTC_2846 9008642 19.48 µM 2.24186261559026 0.0100689350894755 no 71 0.0124851264281799 48 2992898 SGTC_1684 st024538 14.6195 µM 2.23286879864716 0.0103208494246771 no 72 0.0127787988480256 32 6732859 SGTC_2821 7996764 71.43 µM 2.22125605268294 0.0106542357356696 no 73 0.013166811814046 38 2987135 SGTC_922 1866-0035 480 µM 2.20129079070689 0.0112493633094225 no 74 0.0138577222061385 53 3156169 SGTC_810 3825-7150 143 µM 2.1985475748952 0.0113333506135253 no 75 0.0139550540908493 23 22330411 YGL099W LSG1 SGTC_3285 9112818 20.8695 µM 2.19315658235336 0.0114999920148514 no 76 0.0141480497526925 55 17017947 YPR165W RHO1 SGTC_997 3996-0078 137 µM 2.19258553186464 0.0115177678372796 no 77 0.0141686272354785 47 735687 SGTC_2116 5511452 16.8835 µM 2.18636559710179 0.0117129344645584 no 78 0.014394434236349 44 870744 SGTC_230 MPP+ 141.667 µM 2.18445381942434 0.0117734953347741 no 79 0.0144644585874703 44 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death. SGTC_445 e6 berbamine 66 µM 2.1783557102533 0.0119684891777348 no 80 0.0146897822675481 76 6610268 A calcium/calmodulin antagonist. SGTC_2992 9074591 71.4286 µM 2.1728698690475 0.012146292071759 no 81 0.0148950564105219 30 17741321 SGTC_361 000s-0510 1.45 µM 2.16171445310537 0.0125149256387996 no 82 0.0153200964499012 42 660 SGTC_79 0052-0007 94.094 µM 2.15880765265585 0.0126125579571815 no 83 0.0154325462727248 37 2801472 SGTC_1758 st042942 75.2445 µM 2.14778241728372 0.0129888847731398 no 84 0.0158655222215267 44 669317 SGTC_1844 rapamycin 4 nM 2.14258337148796 0.0131696877568468 no 85 0.0160732837834128 107 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2 SGTC_377 3970-0964 33.1 µM 2.13602842376304 0.0134007399885521 no 86 0.0163385485455315 45 16481235 SGTC_909 3448-9333 149 µM 2.11484827493722 0.0141713929358823 no 87 0.017221440445197 37 3344074 SGTC_1909 st060837 51.5 µM 2.1008836465484 0.0147001380983916 no 88 0.017825590653751 48 678937 SGTC_1748 st037455 53.6035 µM 2.09611165753343 0.0148846701605422 no 89 0.0180361435646522 51 580690 SGTC_2696 st077691 74.316 µM 2.0865593540621 0.0152600465195128 no 90 0.0184639923380248 59 757133 SGTC_3296 9122258 64.045 µM 2.08649208873679 0.0152627184100305 no 91 0.0184670355439872 36 4730474 SGTC_2352 9027995 87.8 µM 2.08247835224456 0.0154228796954006 no 92 0.0186493991036242 34 2997347 SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM 2.07631512884677 0.0156716208593394 no 93 0.0189324074879519 46 6857784 SGTC_1928 4'-methoxychalcone 40.3 µM 2.07166719445083 0.015861475905159 no 94 0.0191482443714047 44 641818 SGTC_713 1488-1073 324 µM 2.06598311124622 0.016096332475657 no 95 0.0194150371517075 40 3312542 SGTC_1261 0712-0010 12.7 µM 2.05930235408441 0.0163761736608026 no 96 0.0197326415587939 55 2840123 SGTC_1957 st077035 62.4 µM 2.0434372492213 0.0170574657887093 no 97 0.0205045866279639 37 705593 SGTC_2348 9022543 33.42 µM 2.03855238836576 0.0172720540229803 no 98 0.0207473605793294 99 3162678 YDL140C RPO21 SGTC_2875 9039966 71.43 µM 2.03685900424897 0.0173469794424829 no 99 0.0208320866905254 30 6463691 SGTC_1274 0865-0114 173 µM 2.03522270723392 0.0174196425322823 no 100 0.0209142346236842 54 870624 SGTC_3272 9137413 49.47 µM 2.01249173700268 0.018456246210922 no 101 0.0220840634221722 60 17614870 SGTC_1130 3454-2858 15.9 µM 2.01044614353241 0.0185520565455831 no 102 0.0221919954417871 68 715628 YIL048W NEO1 SGTC_2512 diallyl trisulfide 49.23 µM 2.00892820160569 0.0186234264635605 no 103 0.0222723743007618 53 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent SGTC_3078 9116413 49.47 µM 2.00420587204535 0.0188469552542165 no 104 0.0225240059100142 56 17177322 SGTC_2014 4013930 200 µM 1.99989114950656 0.0190531817600955 no 105 0.0227560095312683 54 64556 SGTC_958 1222-0007 33 µM 1.99682360916066 0.0192009622819527 no 106 0.0229221739648594 59 7312461 SGTC_1608 st001473 40.5 µM 1.99465294312099 0.0193061230589742 no 107 0.023040372504412 69 7292267 SGTC_2408 sulbentine 18.36 µM 1.99204533344557 0.0194330989152318 no 108 0.0231830420610028 81 67686 An antifungal agent of unknown mechanism. YDL205C HEM3 SGTC_3109 9122853 49.47 µM 1.991977886551 0.0194363925881436 no 109 0.0231867421130313 38 1234709 SGTC_2878 9043973 25.97 µM 1.98951562217654 0.0195569588480048 no 110 0.0233221596102516 33 6465167 SGTC_1027 k015-0025 8.67 µM 1.98565660183227 0.0197471956937214 no 111 0.0235357334560217 39 3598955 SGTC_181 1447-1644 8.07 µM 1.9823553202041 0.0199111823663507 no 112 0.0237197432561425 66 534600 SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM 1.97795948321743 0.0201313321012711 no 113 0.023966638808808 54 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM 1.97562229239266 0.020249220126483 no 114 0.0240987859498302 51 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_3032 9089427 49.47 µM 1.97337335405334 0.0203632087277416 no 115 0.0242265205640688 41 17173707 SGTC_551 k048-0028 34.9 µM 1.96974474398968 0.0205482732605321 no 116 0.0244338160948755 67 6836383 SGTC_2615 purpurogallin-4-carboxylic acid 100 µM 1.96534252460941 0.0207747041218905 no 117 0.0246873034412644 67 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase. SGTC_1331 1472-0049 76.2 µM 1.94649367398651 0.0217682391915238 no 118 0.025797733549918 59 24051409 SGTC_3085 9117376 49.47 µM 1.94242713757785 0.0219877734064323 no 119 0.026042706343798 53 16480349 SGTC_2799 7812892 81.82 µM 1.93700031893997 0.0222836523882732 no 120 0.0263726521897618 81 20205235 SGTC_665 3914-0008 307 µM 1.93676920560386 0.0222963272784457 no 121 0.0263867808927972 42 1069549 SGTC_1503 4585-0012 61.3 µM 1.92186241702456 0.0231268015442061 no 122 0.0273115359680622 55 2922052 SGTC_2480 5767542 37.17 µM 1.91320256170544 0.0236211042745934 no 123 0.0278610628548048 49 2867358 SGTC_1993 st073995 70.8 µM 1.90636943886662 0.0240173821610098 no 124 0.0283011454411249 56 3098394 SGTC_685 1278-0033 54.9 µM 1.9049157864489 0.024102401515146 no 125 0.028395509417295 65 3590572 SGTC_522 1273-0010 11.6 µM 1.88964244799695 0.0250110714652675 no 126 0.0294028980129573 70 5705015 SGTC_1434 4073-0095 163 µM 1.88348115607409 0.0253856743119406 no 127 0.0298175956048784 52 24133745 SGTC_2333 9017922 200 µM 1.88065158338354 0.0255592789989448 no 128 0.0300096649330996 54 3163164 SGTC_1760 st045453 10.4495 µM 1.87788254566755 0.0257301309635417 no 129 0.0301986173214018 56 3323419 YIL048W NEO1 SGTC_2872 9044037 25.97 µM 1.87429123989885 0.0259531404346072 no 130 0.0304451471378665 39 6465195 SGTC_1117 retinoic acid 1.10837 µM 1.86736873134135 0.026387571283399 no 131 0.0309250566320085 48 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR). SGTC_2051 5263410 176 µM 1.86671768275534 0.0264287395321054 no 132 0.0309705115315046 60 227584 SGTC_3067 9117431 49.47 µM 1.86099540855407 0.0267928947235111 no 133 0.0313724125452118 87 17150885 SGTC_182 3448-4371 550.524 µM 1.8573633525249 0.0270261987481011 no 134 0.0316297383483944 52 3491403 SGTC_1628 st004252 77.7 µM 1.85493637952707 0.0271830377218179 no 135 0.0318026560873909 56 692968 SGTC_2791 5663188 71.43 µM 1.84602853255919 0.0277652146704325 no 136 0.0324440313194007 81 54690634 SGTC_2343 7990716 14.84 µM 1.84439440330925 0.0278731338695867 no 137 0.0325628411825106 65 6456862 SGTC_1076 itraconazole 331 nM 1.83792482843314 0.0283038257094905 no 138 0.0330367414756269 71 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1 SGTC_544 k015-0020 52.4 µM 1.83596635158298 0.0284352921951276 no 139 0.0331813166526937 71 3008304 SGTC_533 1222-0222 6.71 µM 1.83447142766201 0.0285359833871464 no 140 0.0332920226590752 66 3982874 SGTC_1007 4101-0031 70 µM 1.83381633325283 0.0285802009025479 no 141 0.0333406311868124 71 1146276 SGTC_798 1287-0182 476 µM 1.83137561334966 0.0287454464472116 no 142 0.0335222493299924 61 1649755 SGTC_2686 alizarin 95.37 µM 1.81908933786636 0.0295893807109753 no 143 0.034448900727034 60 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1 SGTC_3247 9135149 49.47 µM 1.81819040901863 0.0296519264638951 no 144 0.0345175177008037 101 8934436 YOR116C RPO31 SGTC_2442 5158906 48.48 µM 1.8170686996974 0.0297301266879316 no 145 0.0346032973654544 47 1893835 SGTC_3256 9138902 49.47 µM 1.81429428153141 0.0299242811692406 no 146 0.0348162157455014 45 17228773 SGTC_1860 st056228 74.6 µM 1.81174403392009 0.0301036745968016 no 147 0.0350128781526311 80 688679 SGTC_1321 1326-2144 215 µM 1.81113061881621 0.0301469571508093 no 148 0.035060317442402 62 3513030 SGTC_2734 clemastine 41.6 µM 1.80862690590142 0.0303241544111315 no 149 0.0352544927831131 65 26987 Clemastine is a selective histamine H1 antagonist. SGTC_2766 oltipraz 83.91 µM 1.8083524022169 0.030343634472953 no 150 0.0352758354613904 86 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40 SGTC_3035 9091303 49.47 µM 1.8074154199222 0.0304102052283731 no 151 0.0353487657342334 51 25237002 SGTC_678 1218-2179 85.9 µM 1.8070334905711 0.0304373752529049 no 152 0.0353785287640006 44 6820081 YOR116C RPO31 SGTC_1699 st031318 29.054 µM 1.8045574283978 0.0306140077609256 no 153 0.0355719824562855 62 5340658 SGTC_3299 9121982 43.1275 µM 1.79454734464656 0.0313367621109852 no 154 0.0363629244682272 60 17594604 YPL160W CDC60 SGTC_2818 7996756 12.99 µM 1.7923669567743 0.0314960490126037 no 155 0.0365371021073872 65 2241621 SGTC_1607 st000305 50.6 µM 1.78086884966293 0.032347144516237 no 156 0.0374669392704038 60 5457690 SGTC_2259 7964009 200 µM 1.77638386876656 0.0326842297350859 no 157 0.0378348340352861 50 313134 SGTC_1873 rapamycin 2 nM 1.77397420255759 0.0328665299740391 no 158 0.038033708778871 62 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1 SGTC_1054 3429-0080 167 µM 1.77273139161289 0.0329608803861143 no 159 0.0381366133965588 56 1162877 SGTC_979 1426-2828 121 µM 1.76585108300952 0.033487259058072 no 160 0.0387104178774719 66 747872 SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM 1.76570019968864 0.0334988794972563 no 161 0.0387230796382588 104 16725076 SGTC_1695 st026914 34.495 µM 1.76076753349124 0.0338806059728402 no 162 0.0391388785268278 60 3289191 SGTC_2136 5328288 199.296 µM 1.76056161462438 0.0338966189948725 no 163 0.0391563151685889 52 262395 SGTC_1746 st038117 42 µM 1.75824364300629 0.0340773029652454 no 164 0.039353031138341 78 2898218 SGTC_987 1497-1013 404 µM 1.7549631377951 0.0343343684102477 no 165 0.0396328066069769 73 1676435 SGTC_1005 4092-0690 4.4 µM 1.74807227244257 0.0348795381896781 no 166 0.0402257567821482 88 1529343 SGTC_849 0386-0493 241 µM 1.7471529073631 0.0349528079972032 no 167 0.0403054090061164 72 726119 SGTC_2895 9054447 58.44 µM 1.73861839469621 0.0356390227320367 no 168 0.0410509543754696 61 2697450 SGTC_2653 dihydrofissinolide 100 µM 1.73648107781192 0.0358125911649003 no 169 0.0412394036437922 56 6857746 SGTC_284 0988-0104 32.6 µM 1.7348618578999 0.0359445463106971 no 170 0.0413826382288244 63 4666532 SGTC_3156 9099931 49.47 µM 1.73158462563979 0.0362128367692888 no 171 0.0416737727646477 63 18111053 SGTC_3185 9108267 49.47 µM 1.72858193692251 0.0364600888596504 no 172 0.0419419723811249 57 4910486 SGTC_479 n-linoleoylglycine 10 µM 1.6995305572888 0.0389243263237844 no 173 0.0446096310327498 76 6433346 An anti-infammatory. SGTC_2677 mitomycin C 100 µM 1.69752482255285 0.039099348104912 no 174 0.0447987411262027 76 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_3325 9138760 55.175 µM 1.69450152886436 0.0393643728858281 no 175 0.0450850107126352 60 43844959 SGTC_1209 2323-2347 50.3 µM 1.69250144276778 0.039540504293319 no 176 0.0452752026281107 66 5412760 SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM 1.69017669197671 0.0397460312395347 no 177 0.0454970780565038 64 521171 SGTC_2673 kobusone 100 µM 1.67951275132417 0.0406999678574356 no 178 0.046526077924614 56 6710676 An epoxy ketone and protein crosslinker. SGTC_3070 9117005 49.47 µM 1.67893622341674 0.0407520657126745 no 179 0.0465822369721316 44 8779016 SGTC_1640 st009078 66.4 µM 1.67307445322238 0.0412848415546473 no 180 0.0471563199964652 82 690618 SGTC_2923 7992654 58.14 µM 1.66581879362707 0.0419521126562845 no 181 0.0478747558689769 82 2985126 SGTC_3019 9081971 49.47 µM 1.66155378137708 0.0423484043665704 no 182 0.0483011384868678 75 16451803 SGTC_1139 k015-0024 46.9 µM 1.65622927498353 0.0428473852851876 no 183 0.0488376984244031 65 2766652 SGTC_405 ebelactone b 50 µM 1.65303230600809 0.0431492620728352 no 184 0.0491621444285338 49 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).  SGTC_1987 st072290 61.9 µM 1.64672786152459 0.0437495985548832 no 185 0.0498069973812713 78 54697379 SGTC_279 1273-0055 2.93 µM 1.64443478036059 0.043969619885355 no 186 0.0500432128939718 82 2847562 SGTC_2222 6885208 172.143 µM 1.64234785095782 0.044170635747922 no 187 0.0502589678598692 57 609514 SGTC_1790 st045711 43.5 µM 1.64068421113857 0.0443314099137396 no 188 0.0504314920337852 37 585119 SGTC_2925 9010536 32.5 µM 1.63931267902296 0.044464309168828 no 189 0.0505740783972893 63 2994177 SGTC_2690 usnic acid 100 µM 1.63155253065375 0.0452223126211043 no 190 0.0513868925581347 79 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_317 4495-0002 170 µM 1.62870635324776 0.0455029166741404 no 191 0.0516875985870349 74 15991618 SGTC_2822 7994718 71.43 µM 1.62309267217366 0.0460604717535161 no 192 0.0522847979257934 93 1018011 SGTC_2749 bexarotene 57.39 µM 1.62263581681675 0.0461060874116405 no 193 0.0523336396102577 74 82146 An retinoic acid receptor inhibitor. SGTC_1756 st041558 35.5 µM 1.62191230897277 0.0461784017601437 no 194 0.0524110627982775 87 3955792 SGTC_2354 9060492 162 µM 1.62066778017808 0.0463030050421252 no 195 0.0525444535930868 85 6471895 SGTC_1797 st048695 56.8 µM 1.61744278440794 0.0466271507802147 no 196 0.0528913683468924 90 592262 YIL048W NEO1 SGTC_507 nimesulide 162 µM 1.61619069536245 0.0467534884678787 no 197 0.0530265449451444 76 4495 A COX2 inhibitor. SGTC_2100 5377183 190 µM 1.61575548971024 0.0467974656414607 no 198 0.0530735942289856 85 2844202 SGTC_1989 st071868 50.2 µM 1.60997078855918 0.0473851624093299 no 199 0.0537021167910846 84 16414057 SGTC_2754 granisetron 64.02 µM 1.608840062606 0.0475007265954986 no 200 0.053825659112567 93 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients. SGTC_3134 9127454 49.47 µM 1.60525181002595 0.0478689544819344 no 201 0.0542191998591362 56 24262820 SGTC_1208 2323-2347 50.3 µM 1.60471576353686 0.0479241594574804 no 202 0.0542781856096744 70 5412760 SGTC_481 bay k-8644 50 µM 1.60469109290507 0.0479267013992009 no 203 0.0542809015506039 82 2303 A calcium channel antagonist. SGTC_1706 st031321 9.9705 µM 1.60284484649382 0.0481172360939708 no 204 0.0544844564470265 80 6103185 SGTC_270 tamoxifen 5.46 µM 1.59363114869498 0.0490771776691994 no 205 0.0555093368074877 91 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  YIL048W NEO1 SGTC_2394 5221648 200 µM 1.59290700357335 0.0491532675314229 no 206 0.0555905274615242 104 788586 SGTC_781 4335-2806 94.4 µM 1.58755326809358 0.0497187408495526 no 207 0.0561936963071955 95 845254 SGTC_3321 9137793 26.8275 µM 1.58729664018535 0.0497459762716544 no 208 0.0562227379188558 103 4904192 SGTC_1009 4106-0057 9.87 µM 1.58629596370442 0.0498522898369092 no 209 0.0563360937488726 97 2928005 SGTC_2885 9057732 51.95 µM 1.58235950250626 0.050272265925175 no 210 0.0567837621062155 101 6471414 SGTC_2514 salinomycin 42.74 µM 1.57566171497939 0.0509933205782117 no 211 0.0575518925271846 92 23682228 A polyether potassium ionophore. SGTC_1833 st055984 71 µM 1.57381259448698 0.0511938321995808 no 212 0.0577653907524141 68 676288 SGTC_2449 5812982 45.77 µM 1.57223506297116 0.051365389189584 no 213 0.0579480233021567 65 776185 SGTC_3312 9133330 71.43 µM 1.56101961472187 0.0525982903573494 no 214 0.0592595614609625 90 17617324 SGTC_2762 leflunomide 42.06 µM 1.5573771799128 0.0530037132988206 no 215 0.0596904804351145 109 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1 SGTC_1077 5-fluorocytosine 377 nM 1.55638971697611 0.0531140492569485 no 216 0.0598077244607815 111 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_1707 st032323 6.317 µM 1.55527583688157 0.0532387291563286 no 217 0.0599401947655006 113 3132057 YMR211W DML1 SGTC_3008 9078912 71.4286 µM 1.55473608383255 0.0532992287067939 no 218 0.0600044685237719 80 16648731 SGTC_229 benomyl 22.8748 µM 1.55399214067316 0.0533827047088111 no 219 0.0600931456728633 88 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C SGTC_911 3456-4043 236 µM 1.55099040162737 0.0537205752479284 no 220 0.0604519920953256 88 914281 SGTC_553 k007-0256 45.7 µM 1.55007204669641 0.0538242813488802 no 221 0.0605621122327823 104 6287000 SGTC_2112 5488546 200 µM 1.54905076072111 0.0539397971483359 no 222 0.0606847590877504 94 600757 SGTC_2883 9059145 45.46 µM 1.54805329137341 0.0540528084680314 no 223 0.0608047332320305 106 16476510 SGTC_3022 9087993 49.47 µM 1.54727154036271 0.0541415102573024 no 224 0.0608988906757933 77 17173644 SGTC_3209 9113616 49.47 µM 1.54689909425925 0.0541838105463314 no 225 0.0609437897566658 108 16649353 SGTC_53 0973-0023 39.979 µM 1.54634545511521 0.0542467380281642 no 226 0.0610105798231564 87 674768 SGTC_1232 0279-0259 161 µM 1.54463086261079 0.0544419881740507 no 227 0.0612177883240261 85 1560000 SGTC_1922 5578187 25 µM 1.54246078077318 0.054689903923268 no 228 0.0614808306738728 94 1350412 SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM 1.53954814725939 0.0550240526541279 no 229 0.0618352665740703 53 4000243 SGTC_1418 3966-3099 2.4 µM 1.53936187835054 0.0550454769142991 no 230 0.0618579876279126 115 740335 SGTC_268 camptothecin 39.6153 µM 1.53789022092755 0.0552149756967937 no 231 0.0620377293733584 151 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_2450 5739737 12.93 µM 1.53661434731478 0.0553622583928897 no 232 0.0621938885228385 83 2262825 SGTC_1390 3413-2614 145 µM 1.5334361923578 0.0557304832186859 no 233 0.0625842084985481 112 3421432 SGTC_2261 9010538 184.68 µM 1.53189259064795 0.0559100227042044 no 234 0.0627744711073779 89 6457250 SGTC_659 k018-0002 107 µM 1.53148105524402 0.0559579661919602 no 235 0.0628252725253583 97 6797879 YHR007C ERG11 SGTC_227 fluconazole 33.516 µM 1.53063890890278 0.0560561765269116 no 236 0.0629293299569173 148 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C SGTC_1211 1056-0033 32.3 µM 1.5278801562554 0.0563788520477457 no 237 0.0632711479630124 85 6741922 SGTC_3089 9117425 49.47 µM 1.527800412675 0.0563882009237204 no 238 0.0632810498935471 75 9401657 SGTC_1108 betulinic acid 729.144 nM 1.52596391247836 0.056603844480519 no 239 0.0635094260450928 84 64945 Apoptosis-inducing agent of unknown mechanism. SGTC_170 4197-0004 226 µM 1.52394168217962 0.0568420477228159 no 240 0.0637616399269855 99 218692 SGTC_379 3970-0972 5.9 µM 1.51929166270767 0.0573927790864727 no 241 0.064344548696159 88 2898042 YBL034C STU1 SGTC_2109 5483026 200 µM 1.51577721934729 0.057811795701219 no 242 0.0647878471163385 146 759335 SGTC_2841 9004761 38.96 µM 1.51128318560633 0.0583511056711852 no 243 0.0653581580312148 74 2991039 SGTC_543 3844-1095 191 µM 1.51057652222091 0.0584362677300609 no 244 0.0654481896940267 108 4230703 SGTC_2756 carbadox 75.1 µM 1.50920886226894 0.0586013656338362 no 245 0.0656227080782223 117 2553 A substituted quinoxaline antibiotic. YLR208W SEC13 SGTC_2049 5262831 67.185 µM 1.5070297178349 0.0588651786832965 no 246 0.0659015200002043 96 763417 SGTC_2566 crystal violet carbinol 226 nM 1.50566572513089 0.0590307809307475 no 247 0.0660765034375294 139 68050 Cationic dye that binds acidic phospholipids including cardiolipin. SGTC_534 k292-0788 63.4 µM 1.50448840436114 0.0591740130228282 no 248 0.0662278284094519 113 4146317 SGTC_1720 st037298 9.481 µM 1.50367387206967 0.0592732679175958 no 249 0.066332679959376 97 597396 SGTC_1876 myriocin 605 nM 1.5027161313302 0.0593901404262863 no 250 0.06645613055281 105 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1 SGTC_1588 farnesol 29.9 µM 1.4993818057029 0.0597984358968223 no 251 0.0668873054369868 93 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_2720 fluspirilene 36.88 µM 1.49904298498283 0.0598400480135285 no 252 0.066931240543256 85 3396 An atypical antipsychotic. SGTC_2652 actinonin 100 µM 1.49827295193374 0.0599347036351296 no 253 0.0670311742545568 91 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase. SGTC_2961 9083290 32.55 µM 1.49589534284307 0.0602277092527965 no 254 0.0673404650639284 87 17741490 SGTC_1548 st061468 90.8 µM 1.4947716855771 0.0603665732264446 no 255 0.0674870191330556 68 390799 SGTC_603 3794-0023 45.9 µM 1.49316360365748 0.0605657391693646 no 256 0.0676971833753984 100 3802260 SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM 1.49059919777172 0.0608844119011545 no 257 0.0680333775363497 95 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis. SGTC_1743 st037606 46.3785 µM 1.48723046047435 0.061305027509135 no 258 0.0684769768117068 90 590142 YLR208W | YDL195W SEC13 | SEC31 SGTC_297 0986-0032 24 µM 1.48720717419457 0.0613079428807087 no 259 0.0684800509231499 104 2847425 SGTC_2593 nobiletin 86.24 µM 1.48719851538666 0.061309026964814 no 260 0.0684811940328719 99 72344 An anti-infammatory. SGTC_1212 0520-0165 585 µM 1.47737318660658 0.0625488393201189 no 261 0.0697878147917662 104 5403258 SGTC_1986 st071812 45 µM 1.47085211516766 0.0633824352133919 no 262 0.0706655574616395 89 11838594 SGTC_357 1325-0123 420 µM 1.46918505661639 0.06359691902532 no 263 0.0708913011618044 94 1098503 SGTC_3198 9112019 49.47 µM 1.46663350031331 0.0639262955484857 no 264 0.0712378908834585 109 45595555 SGTC_2674 ligustilide 100 µM 1.46452242301043 0.0641998128773896 no 265 0.0715256305009805 107 5319022 A signalling regulator. SGTC_2218 6965428 192.983 µM 1.46372293781561 0.0643036336688329 no 266 0.0716348327763331 83 675684 SGTC_1819 st053448 58.6 µM 1.46139269221453 0.0646069827779602 no 267 0.0719538525197883 115 2857616 SGTC_3029 9088683 49.47 µM 1.46080902714594 0.0646831375282695 no 268 0.0720339288996477 83 25236615 SGTC_2612 dictamnine 15.46 µM 1.4602296259152 0.0647588048814801 no 269 0.0721134878563506 136 68085 A quinoline derivative and established mutagen. YOR116C RPO31 SGTC_3245 9134821 49.47 µM 1.4580733756962 0.0650410060557037 no 270 0.072410159549385 118 17014901 SGTC_2379 9035213 200 µM 1.45570198026355 0.0653524656071127 no 271 0.0727375111183155 109 646551 SGTC_604 1000-0114 314 µM 1.44713271351171 0.0664876060849148 no 272 0.0739298786633949 96 1572745 SGTC_1501 4491-0275 38.4 µM 1.44669509562883 0.0665459828809561 no 273 0.0739911693357812 93 5104718 SGTC_3276 9139060 49.47 µM 1.44615290356534 0.0666183645519158 no 274 0.0740671600070443 134 4870619 SGTC_1964 st076914 61 µM 1.44399532164311 0.066907001716359 no 275 0.0743701456664087 129 24208661 SGTC_3015 9080845 49.47 µM 1.43927719102016 0.0675415542122979 no 276 0.0750360012894694 106 5296973 SGTC_2015 5119600 184 µM 1.43777783787309 0.0677441764923896 no 277 0.075248549730642 122 2828786 SGTC_2882 9058044 58.44 µM 1.43487457726585 0.0681378570107541 no 278 0.0756614206848367 105 18076804 SGTC_3012 9080433 71.4286 µM 1.43394309809374 0.0682645385541907 no 279 0.0757942507995158 122 17688859 SGTC_441 propafenone 146 µM 1.43303225808186 0.0683885888567422 no 280 0.075924309423866 113 4932 Slows the influx of sodium ions into the cardiac muscle. SGTC_2567 aureobasidin a 60 nM 1.4311312325895 0.0686480560401162 no 281 0.0761963037795016 163 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1 SGTC_2467 5474540 200 µM 1.42664238625241 0.0692637421896953 no 282 0.0768415000665661 113 5413519 SGTC_2287 7945887 168.79 µM 1.42649046028345 0.0692846544034523 no 283 0.0768634093170403 118 1245853 SGTC_1940 st075990 51.1 µM 1.42320057055614 0.0697386931733043 no 284 0.0773390101354631 97 1084979 SGTC_2372 9071633 200 µM 1.42251212266764 0.0698339952368857 no 285 0.077438817405062 97 21321366 SGTC_2492 derrusnin 100 µM 1.42011987548236 0.0701659341822397 no 286 0.0777863924413627 113 1715307 Part of coumarin class of compounds. SGTC_1214 0358-0031 63.7 µM 1.41759265344951 0.0705179185557523 no 287 0.078154863125742 110 4301366 SGTC_929 2805-0021 398 µM 1.41449549160944 0.0709511316542239 no 288 0.0786082350876522 117 3098024 SGTC_1489 4065-0444 182 µM 1.41448035790289 0.0709532534770985 no 289 0.078610455289025 95 2877968 SGTC_936 3005-4620 401 µM 1.41321981468347 0.0711301592295726 no 290 0.0787955510898312 116 777207 SGTC_1282 0886-0010 32.4 µM 1.41128986102882 0.0714016666147572 no 291 0.0790795814192209 129 2836211 YNL267W PIK1 SGTC_1269 0831-0796 3.05 µM 1.409004477087 0.0717242040337331 no 292 0.0794169221462422 109 927758 SGTC_431 k089-0097 107 µM 1.40835901242832 0.071815500892948 no 293 0.0795123947957012 120 5499420 SGTC_752 1896-0090 130 µM 1.40750580918731 0.0719363177894451 no 294 0.079638727943162 114 772567 SGTC_2495 cafestol 54.53 µM 1.39849778904626 0.073221414577426 no 295 0.080981818070345 139 16667697 An anti-infammatory. SGTC_2411 st077133 39.94 µM 1.39616611744568 0.0735568987665369 no 296 0.0813322386549186 123 1403142 YNL221C POP1 SGTC_1307 1187-1599 12.2 µM 1.39477369470763 0.0737578022757744 no 297 0.0815420468800586 132 1538471 SGTC_1299 1079-1439 3.74 µM 1.39464361283006 0.0737765923342013 no 298 0.0815616682530849 120 323161 SGTC_2633 5,7-dihydroxyisoflavone 100 µM 1.39121992091968 0.0742724539888473 no 299 0.0820793741043158 111 5377381 SGTC_1116 jasmonic acid  1.58368 µM 1.39099258754827 0.0743054691274617 no 300 0.0821138372564853 107 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid. SGTC_3163 9099914 49.47 µM 1.3879381350624 0.0747501482459769 no 301 0.0825779420941466 116 16268368 SGTC_3329 9141233 27.5565 µM 1.38753607873665 0.0748088320911586 no 302 0.0826391787845765 114 4909101 YNL103W MET4 SGTC_247 mechlorethamine 29.705 µM 1.38491764931081 0.0751918763349549 no 303 0.0830388248152577 88 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links. SGTC_2969 9091408 28.7 µM 1.38323536169269 0.0754387623340519 no 304 0.0832963551484145 115 4286311 SGTC_1798 st045719 60.953 µM 1.382181631303 0.0755937180949556 no 305 0.0834579693486483 113 3980186 SGTC_3189 9110682 49.47 µM 1.37528793703948 0.0766134555428337 no 306 0.0845210974135421 112 17122418 SGTC_1370 2001-0092 44.6 µM 1.37166444486382 0.0771536321310222 no 307 0.0850839608627767 120 790957 SGTC_3112 9123419 49.47 µM 1.36821608902428 0.0776703829261503 no 308 0.0856222234717673 122 17015854 SGTC_3145 9085516 49.47 µM 1.36507525772789 0.0781433324696318 no 309 0.0861146988239929 113 25236195 SGTC_3110 9122132 49.47 µM 1.3649255057202 0.0781659367184853 no 310 0.086138232421715 92 918317 SGTC_2336 9001819 198.65 µM 1.36327924645069 0.0784147576242472 no 311 0.0863972600687977 165 2989602 SGTC_701 4424-0219 185 µM 1.36082060335154 0.0787874823428138 no 312 0.086785194593365 118 2911779 SGTC_1917 st066507 28.5 µM 1.356762912321 0.0794055526996148 no 313 0.0874282776625666 132 3156428 SGTC_1459 k035-0031 35.7 µM 1.35345452428193 0.0799121989088109 no 314 0.0879552343623086 98 3877128 YMR208W ERG12 SGTC_571 k831-0106 44.2 µM 1.35237692395875 0.0800777492057041 no 315 0.0881273838052159 124 4783639 SGTC_760 0568-0725 82.9 µM 1.35216498047339 0.080110340290584 no 316 0.0881612718660605 117 3916171 SGTC_646 4092-0839 27.3 µM 1.35128292314608 0.0802460841812031 no 317 0.0883024100902386 132 877796 SGTC_965 1291-5240 308 µM 1.35106086339432 0.0802802853608011 no 318 0.0883379684478664 117 2834598 SGTC_2353 9059630 146.67 µM 1.35018266312885 0.0804156518687305 no 319 0.0884786989290221 103 4779114 SGTC_3059 1327-0034 3 µM 1.34965221233811 0.0804974994890639 no 320 0.0885637838753213 122 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_2356 9061756 188.97 µM 1.3495209498251 0.0805177627729036 no 321 0.088584847945032 107 20104043 SGTC_1271 0832-2808 169 µM 1.34921594566629 0.0805648618165943 no 322 0.088633807241964 137 3663794 SGTC_1653 st012112 65 µM 1.34527403322046 0.0811754496734251 no 323 0.0892683779631063 93 720429 SGTC_3241 9133421 49.47 µM 1.33667941359085 0.0825188215613394 no 324 0.0906636522539411 106 17018221 SGTC_3228 9131799 49.47 µM 1.33621716607442 0.0825915440568034 no 325 0.09073915091755 120 17015818 SGTC_1651 st011928 86.1 µM 1.33428847230026 0.0828954939283061 no 326 0.0910546670439238 117 720198 SGTC_2520 obtusaquinone 4.71 µM 1.33385764989087 0.0829635036362112 no 327 0.0911252565834857 131 5967872 SGTC_3268 9137683 49.47 µM 1.33296973533722 0.08310380237374 no 328 0.0912708679165222 141 1953228 SGTC_2099 5377090 177.372 µM 1.33079517829349 0.0834481560392182 no 329 0.0916282074645269 135 2243829 SGTC_2042 p-Dimethylaminoacetophenone 200 µM 1.32771130825391 0.0839383419925303 no 330 0.0921367481748414 112 75037 A free radical scavenger. SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM 1.32166201198796 0.0849061628545919 no 331 0.0931403618780907 138 5024745 SGTC_2723 salbutamol 83.58 µM 1.31965458922469 0.0852291701263753 no 332 0.0934751839925749 107 9884233 β2-adrenoceptor agonist SGTC_3147 9097027 49.47 µM 1.31955823668537 0.0852446969960502 no 333 0.0934912771580024 136 25236841 SGTC_626 0214-0009 33 µM 1.31856755604139 0.0854044646025748 no 334 0.0936568630857277 127 3437874 SGTC_1458 k015-0034 6.33 µM 1.31573509418324 0.0858624945459172 no 335 0.0941314854346244 102 3598957 SGTC_2381 9035592 200 µM 1.31544094053563 0.0859101665349834 no 336 0.0941808769075018 112 4749657 SGTC_2223 6903751 107.57 µM 1.31389311645077 0.0861613409120046 no 337 0.0944410877536284 112 5598863 SGTC_2404 5161160 200 µM 1.3133323267776 0.086252478938747 no 338 0.0945354950352698 157 2831543 SGTC_1180 1193-0155 285 µM 1.31226601072704 0.0864259726110614 no 339 0.0947151980761824 127 2921347 SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM 1.31079467575334 0.0866657926365239 no 340 0.0949635709211153 138 688798 SGTC_1025 k007-0731 70 µM 1.30980617271034 0.0868271926403154 no 341 0.0951307072159211 113 6256118 SGTC_2589 lobaric acid 100 µM 1.30962660445326 0.0868565361305026 no 342 0.0951610918905243 98 73157 A novel microtubule depolymerizer. SGTC_2413 inermin 26.06 µM 1.3085751742369 0.0870285004732018 no 343 0.0953391474364845 161 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1 SGTC_438 sphingosine 6.67 µM 1.30427889797232 0.087733811454782 no 344 0.0960692537449184 98 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes. SGTC_895 0964-0006 13.7 µM 1.29907355740009 0.0885940641744318 no 345 0.0969593433704537 159 6738897 SGTC_6 0844-0013 19.835 µM 1.29128351869805 0.0898931877222415 no 346 0.0983026917463442 161 1584900 SGTC_3221 9128209 49.47 µM 1.29062339322601 0.0900039223783611 no 347 0.0984171500953041 118 16460723 SGTC_743 1275-0778 158 µM 1.28761457888157 0.0905099287223341 no 348 0.0989400809315144 154 2849257 YMR203W TOM40 SGTC_725 1497-0963 19 µM 1.28504153743819 0.090944321868375 no 349 0.0993888846456843 111 3549977 SGTC_1318 1280-3875 124 µM 1.28475619330538 0.0909925901355139 no 350 0.0994387474269132 152 373245 SGTC_3079 9117512 49.47 µM 1.28352718865933 0.0912007034102779 no 351 0.0996537202156889 158 7185044 SGTC_2721 ifenprodil 61.44 µM 1.283020801143 0.0912865550455371 no 352 0.0997423942951397 119 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor. SGTC_2753 fluvastatin 17.09 µM 1.28134893643547 0.0915704241506943 no 353 0.100035565688053 137 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5 SGTC_2165 5727197 32.143 µM 1.27733331410384 0.0922549159290778 no 354 0.10074229848359 133 1361712 SGTC_338 4055-0136 114 µM 1.27001104139099 0.0935127863683734 no 355 0.102040348574483 109 2900563 SGTC_395 anisomycin 6.25 µM 1.26128411050176 0.095028448906301 no 356 0.103603251954294 129 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_2058 5236698 133 µM 1.25878038991508 0.0954666086162737 no 357 0.10405483266752 128 766665 SGTC_896 0964-0007 44.5 µM 1.25852669228676 0.0955110894090486 no 358 0.104100670061401 132 6756758 SGTC_808 0711-0032 135 µM 1.25601043633152 0.0959530905833251 no 359 0.104556093145591 146 4252555 SGTC_1010 4112-3296 15.2 µM 1.25356851222433 0.0963834712418036 no 360 0.104999441082855 112 704384 SGTC_2141 5621638 7.665 µM 1.25344206859936 0.0964057950589039 no 361 0.105022434782895 124 2856238 SGTC_1113 artemisinin 1.17947 µM 1.25008706481039 0.0969995147727499 no 362 0.105633872224189 170 2240 An anti-malaria and mitochondrial poison. SGTC_3046 9092212 49.47 µM 1.24945172194454 0.0971122501321035 no 363 0.105749950471249 128 25236637 SGTC_1089 terbinafine 2.25 µM 1.24817120933396 0.0973397566943401 no 364 0.105984182504802 124 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_1655 st012546 55.1 µM 1.24511616833885 0.0978841195864665 no 365 0.106544525859575 114 720985 YLR208W SEC13 SGTC_323 4013-0906 34.3 µM 1.2442483432991 0.0980391592791492 no 366 0.106704088193198 122 2910086 SGTC_2278 7948257 134.34 µM 1.24305397391528 0.0982528312838679 no 367 0.106923972385675 116 1247028 SGTC_2227 7312221 64.1025 µM 1.24298070910422 0.0982659494119614 no 368 0.106937471118788 142 887188 YOR168W | YOR169C GLN4 | YOR169C SGTC_2713 st079149 53.4 µM 1.24085713373201 0.0986467350831419 no 369 0.10732926532135 134 3103253 SGTC_2511 berberine 10.47 µM 1.2377014395044 0.099214586903412 no 370 0.107913392601894 142 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_477 mead ethanolamide 10 µM 1.23432865989726 0.0998241407715963 no 371 0.108540230272154 76 16061185 SGTC_2438 5259590 200 µM 1.23308986058344 0.100048711322645 no 372 0.108771119976232 141 1201127 SGTC_1216 1165-0504 9.65 µM 1.23134430038634 0.100365773684613 no 373 0.109097059833963 146 6304004 SGTC_2427 5545055 42.75 µM 1.2311290717128 0.100404918397326 no 374 0.10913729698162 149 5372858 SGTC_2281 7943571 200 µM 1.23072795700711 0.100477900856766 no 375 0.109212314105212 145 1244024 SGTC_1505 k297-0037 20.6 µM 1.2306345326736 0.10049490488617 no 376 0.10922979179407 120 4089396 SGTC_2596 sinensetin 100 µM 1.23055219017611 0.100509893667089 no 377 0.109245197975242 133 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets. SGTC_3191 9110352 49.47 µM 1.2299566113791 0.10061835526786 no 378 0.109356676529048 127 17122424 SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM 1.22966094984975 0.100672230260025 no 379 0.109412047860022 166 5393153 SGTC_994 3910-0338 138 µM 1.22911884570838 0.100771066298497 no 380 0.109513625134975 150 3479481 SGTC_2937 9044753 11.33 µM 1.22870390997872 0.100846764879012 no 381 0.109591419851906 121 6465530 YGL099W LSG1 SGTC_2750 bromebric acid 70.15 µM 1.22788868011947 0.100995611647876 no 382 0.109744379736687 131 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2 SGTC_2035 5154463 94.595 µM 1.22636399803678 0.101274421757311 no 383 0.110030863879507 166 2769623 SGTC_1773 st048542 73.5835 µM 1.22555056230006 0.10142339942378 no 384 0.110183925835684 181 3237138 SGTC_1169 aniline yellow 25.8 µM 1.22531283506981 0.101466968392068 no 385 0.110228687137569 139 6051 A DNA damaging agent. SGTC_1140 3229-1848 2.98 µM 1.22267496307761 0.101951334076728 no 386 0.110726243522281 131 2849525 SGTC_1546 5-methoxyflavanone 78.7 µM 1.22262253281089 0.101960978340321 no 387 0.110736149223975 122 147795 SGTC_1831 st055328 12 µM 1.22042981371345 0.102364911838581 no 388 0.111150990557834 143 1103068 SGTC_3115 9123671 49.47 µM 1.21875383735373 0.102674436918246 no 389 0.111468818631952 139 3286988 SGTC_75 0159-0059 199.013 µM 1.21581209898826 0.103219371148565 no 390 0.112028254386481 154 5377270 SGTC_2701 st077767 14.721 µM 1.21579019084375 0.103223437325696 no 391 0.112032428214973 138 5721188 SGTC_1632 st005650 90 µM 1.21261570447815 0.103813855770061 no 392 0.112638390889216 132 2759605 SGTC_2158 5657123 3.6195 µM 1.20903177912948 0.104483364744554 no 393 0.113325318278519 148 2858827 SGTC_2680 butyl paraben 22.24 µM 1.20807142171804 0.104663298292065 no 394 0.113509895610244 153 7184 An antifungal and steroid mimetic. SGTC_3206 9114350 49.47 µM 1.20617651777873 0.105018987525187 no 395 0.113874718068897 127 17087243 SGTC_773 4358-1457 44.6 µM 1.20327775528936 0.105564801072391 no 396 0.114434427113316 165 1186886 SGTC_689 0833-0039 98 µM 1.20273841684531 0.105666580079643 no 397 0.114538781276548 151 5374726 SGTC_3257 9139206 32.98 µM 1.19932802153826 0.106311801637012 no 398 0.115200211683961 135 4910041 SGTC_2795 7780010 54.55 µM 1.19786246763984 0.106589945943377 no 399 0.115485281683734 143 953673 SGTC_2964 9083345 53.42 µM 1.19622096980497 0.1069021055051 no 400 0.115805169863075 150 17741579 SGTC_256 clotrimazole 625 nM 1.19618810156377 0.106908362704984 no 401 0.115811581506994 134 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C SGTC_1691 st019933 84.6 µM 1.19221516709419 0.107666646379626 no 402 0.116588443902143 155 6176082 SGTC_2614 arthonioic acid 13.39 µM 1.19038439978848 0.108017372202908 no 403 0.116947670862047 127 6710684 SGTC_1260 0700-1617 7.75 µM 1.18705577924273 0.108657152520952 no 404 0.117602809699334 146 2853078 SGTC_2622 2-methoxyxanthone 59.94 µM 1.18503423444573 0.109047032993775 no 405 0.118001955755726 144 71034 A hepatoprotective. SGTC_3172 9105863 49.47 µM 1.18223554261872 0.109588454169287 no 406 0.118556126701394 141 2348785 SGTC_1500 4488-1866 171 µM 1.17189756372672 0.111605116614773 no 407 0.120619092660042 150 2900003 SGTC_650 1328-0195 38 µM 1.17125623795381 0.111731091056148 no 408 0.120747898069255 142 2780821 SGTC_686 1319-0111 510 µM 1.17109734298205 0.111762318219144 no 409 0.120779825877404 151 4562600 SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM 1.16975878663358 0.112025628596842 no 410 0.121049026666025 159 688788 SGTC_143 4032-1194 15.74 µM 1.16958765138294 0.112059324940722 no 411 0.121083474562346 165 1806963 SGTC_2726 cimetidine 79.27 µM 1.16688641996948 0.112592154515996 no 412 0.12162812038625 153 2756 A P450 inhibitor, histamine H2-receptor antagonist. SGTC_2126 5251174 33.877 µM 1.16557013472847 0.112852452181551 no 413 0.121894144280362 147 790722 SGTC_648 0375-0473 33.3 µM 1.16503661916601 0.112958078057921 no 414 0.12200208516704 162 1713139 SGTC_2719 novobiocin 32.65 µM 1.16299386860051 0.113363155880074 no 415 0.122415995051442 146 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication. SGTC_971 1315-0384 26.7 µM 1.16297464518958 0.113366972800738 no 416 0.122419894847002 149 6769120 SGTC_3038 9091290 49.47 µM 1.16264172373891 0.113433090842302 no 417 0.122487447450792 134 25236843 SGTC_2018 5133068 143 µM 1.1612656057481 0.113706678977771 no 418 0.12276695103017 145 785362 SGTC_2735 sertaconazole 140 nM 1.1604096304449 0.113877093846379 no 419 0.122941033824223 157 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C SGTC_1323 1348-1351 11.2 µM 1.16039674654155 0.113879660273396 no 420 0.12294365539171 145 6989654 SGTC_3087 9117406 49.47 µM 1.15943646570444 0.11407106077949 no 421 0.123139160008378 129 42546093 SGTC_2180 6301957 200 µM 1.15897750964198 0.114162619516036 no 422 0.12323267628762 155 845462 SGTC_60 0986-0278 202 µM 1.15456902852633 0.115044749476294 no 423 0.124133477887513 144 3110598 SGTC_2446 5162541 200 µM 1.15228113152114 0.115504459741599 no 424 0.124602783962505 141 1549321 SGTC_3239 9133757 49.47 µM 1.15131658681519 0.115698657635911 no 425 0.124801007893482 144 17036923 SGTC_2858 9025781 8.96 µM 1.14928861533266 0.116107718109347 no 426 0.125218495470373 160 4894980 YPL153C RAD53 SGTC_3220 9131269 49.47 µM 1.14620190020791 0.116732305422135 no 427 0.125855810918772 147 17722206 SGTC_3267 9137951 49.47 µM 1.14552878455103 0.116868824089666 no 428 0.125995089338428 157 16643986 SGTC_3141 9094609 49.47 µM 1.14387002797725 0.117205729521433 no 429 0.126338771295304 187 25236309 YDL196W YDL196W SGTC_2385 9074692 200 µM 1.14314122391487 0.117353972228354 no 430 0.126489980423761 131 17046906 SGTC_2177 5811945 192 µM 1.13949899328698 0.118096811683538 no 431 0.127247543968807 160 5343475 SGTC_621 3584-0052 32.1 µM 1.1385301632611 0.11829496504636 no 432 0.127449585556984 152 2273927 SGTC_1747 st037496 66.6 µM 1.13821978573771 0.11835849578669 no 433 0.127514359412044 181 723305 SGTC_1406 3909-7906 11.9 µM 1.13815318415582 0.118372131513736 no 434 0.127528261729627 149 X1406 SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM 1.12656212873221 0.120762171498604 no 435 0.129963829334936 151 364106 SGTC_2079 5212404 121 µM 1.12077321006423 0.12196846375712 no 436 0.131192205165037 141 758462 SGTC_3291 9121177 71.43 µM 1.12012660480863 0.122103726678032 no 437 0.131329907376694 145 17015612 SGTC_3300 9124615 50.48 µM 1.11829508127539 0.122487433473742 no 438 0.13172049349477 154 24824903 SGTC_2242 6630449 61.2675 µM 1.11480097970201 0.123221797740657 no 439 0.132467858281182 145 691249 YDR170C SEC7 SGTC_1040 k898-0338 155 µM 1.11278207661254 0.123647519450885 no 440 0.132901017487059 166 20969351 SGTC_1784 st039334 36.3 µM 1.11222951282966 0.12376421668267 no 441 0.133019740810032 178 3496984 SGTC_2733 amorolfine 100 µM 1.11072905043976 0.124081491722106 no 442 0.133342496930051 175 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_96 0929-0093 37.281 µM 1.11064635636694 0.124098994039881 no 443 0.133360300443244 178 6991579 SGTC_214 4373-3496 70 µM 1.10902792623234 0.124441884827275 no 444 0.133709067471212 184 3779166 SGTC_2047 4141938 200 µM 1.10583887324374 0.125119475104672 no 445 0.13439813307211 176 3807862 SGTC_37 0566-0070 1.56 µM 1.10528479212703 0.125237465070631 no 446 0.134518102756739 149 1626686 SGTC_1956 st077085 54 µM 1.10384463118453 0.125544506480997 no 447 0.134830270298545 181 24208685 SGTC_1810 st050138 53 µM 1.10328429745925 0.125664111116165 no 448 0.1349518617602 189 3444541 SGTC_1813 st051246 8.6015 µM 1.10078610067324 0.12619832469357 no 449 0.135494881242115 151 5291959 SGTC_29 0299-0004 12.984 µM 1.10026151385564 0.12631070296352 no 450 0.13560909777781 132 16871 A napthoquinone isolated from Swertia calycina. SGTC_906 1165-0455 526 µM 1.09919213180302 0.126540004530025 no 451 0.135842134995659 169 3252859 SGTC_1011 4112-3381 17.4 µM 1.09813088637065 0.12676784791073 no 452 0.136073670066123 166 2877139 SGTC_1286 0929-0070 131 µM 1.09614444147028 0.127195093768866 no 453 0.13650778434348 170 1420408 SGTC_2160 5660466 132.927 µM 1.09506191302045 0.127428345966472 no 454 0.136744756596096 170 2859134 SGTC_1657 st012939 43.4 µM 1.09087385170672 0.128333547582201 no 455 0.137664197181063 134 24207257 SGTC_3304 9125678 46.087 µM 1.08912653935596 0.12871252594301 no 456 0.138049043993138 169 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2 SGTC_2931 9014674 55.67 µM 1.08825913969743 0.128900946262536 no 457 0.138240361667103 161 2996810 SGTC_2534 helenine 20.12 µM 1.08378418241974 0.129876054887692 no 458 0.139230250034092 168 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58 SGTC_1229 0139-0193 12.2 µM 1.08333228066089 0.129974808999243 no 459 0.139330480987405 172 3090752 SGTC_210 3551-0445 56.827 µM 1.08157039141709 0.130360331067315 no 460 0.139721733431159 154 2865180 YOR207C RET1 SGTC_592 k241-0073 46.5 µM 1.08108749921702 0.130466131522305 no 461 0.139829096769216 173 4230158 SGTC_2342 7990637 118.86 µM 1.08047124912358 0.130601236584515 no 462 0.139966191522781 179 2033102 YER133W GLC7 SGTC_1643 st009866 20.2 µM 1.08036145588068 0.130625317517826 no 463 0.13999062638047 153 3156273 YOR207C RET1 SGTC_724 3910-0327 137 µM 1.08024421204653 0.130651035977373 no 464 0.140016722592715 178 2885483 SGTC_1924 st058459 75.1 µM 1.07656253480441 0.131460425477837 no 465 0.140837874681544 148 688683 SGTC_1250 0485-0349 40.2 µM 1.07563246035557 0.131665441985495 no 466 0.141045832070057 160 6842794 YDL195W SEC31 SGTC_2578 7,8-dihydroxyflavone 64.44 µM 1.07525303706347 0.131749141673934 no 467 0.141130727932905 146 1880 Intensifies effect of antibiotics on Staphylococcus aureus. SGTC_246 cycloheximide 667 µM 1.0742619703018 0.131967941315643 no 468 0.14135264228972 172 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells. SGTC_378 3970-0959 8.33 µM 1.07333595513413 0.132172605759806 no 469 0.14156020426692 176 6615653 SGTC_2403 6032726 181.2 µM 1.07217044687188 0.132430512985607 no 470 0.141821740885804 152 2881040 SGTC_1168 k815-0004 80.5 µM 1.07199580852567 0.132469187346788 no 471 0.141860957386452 182 642433 SGTC_2031 5180455 200 µM 1.07118374285499 0.132649124770227 no 472 0.142043409976605 168 29949 SGTC_216 k038-0035 28.382 µM 1.06992417574871 0.132928552479745 no 473 0.142326720049289 195 4444231 YPR107C YTH1 SGTC_1433 4060-0023 7.6 µM 1.06920060798257 0.133089254964025 no 474 0.142489642417855 179 3840627 SGTC_1066 ketoconazole 628 nM 1.0680089435295 0.133354211844639 no 475 0.142758238769383 176 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W SGTC_809 3998-0021 90 µM 1.06781649524504 0.133397035162736 no 476 0.14280164791487 183 715485 SGTC_1633 st005664 67.9 µM 1.0670797829923 0.13356105473743 no 477 0.14296790513211 153 2063822 SGTC_1348 1493-0373 93.8 µM 1.06614372041894 0.133769657097529 no 478 0.143179339256953 179 3010129 SGTC_1450 4112-4260 37.6 µM 1.06601012365799 0.133799447505649 no 479 0.143209532781471 174 1633175 SGTC_427 1354-0053 47.3 µM 1.06448922880692 0.134138909527237 no 480 0.14355356565034 152 6813657 SGTC_3088 9117578 49.47 µM 1.06326463186699 0.13441266781055 no 481 0.143830979783097 173 678341 SGTC_2951 9072950 58.06 µM 1.06057870398519 0.135014448856976 no 482 0.14444070245516 189 16488155 SGTC_254 nsc-64875 3.808 µM 1.06011360459919 0.135118841583266 no 483 0.144546459623414 143 56993 SGTC_276 colchicine 750 µM 1.0576232696672 0.135678745002353 no 484 0.14511361472029 174 2833 A microtubule depolymerizer. SGTC_3193 9111931 49.47 µM 1.05327744309004 0.136659621797563 no 485 0.14610692698949 177 17087244 SGTC_1976 st070609 63.5 µM 1.05290023965176 0.136744986782442 no 486 0.146193358133983 169 682556 SGTC_940 3232-1287 54.8 µM 1.05060677781945 0.137264805184731 no 487 0.146719613425834 159 1585493 YIL048W NEO1 SGTC_2387 9077560 195.08 µM 1.05044717188615 0.137301030398522 no 488 0.146756283678224 165 5303272 SGTC_1584 6-fluoro-dl-tryptophan 90 µM 1.05037640181697 0.137317094928659 no 489 0.146772545419135 169 94937 An inhibitor of serotonin biosynthesis. SGTC_1159 4092-0538 61.2 µM 1.04953450505565 0.137508300679972 no 490 0.146966091501947 175 717301 SGTC_3259 9138485 49.47 µM 1.04774313399767 0.13791574903612 no 491 0.147378484326616 139 17646153 SGTC_1793 st048256 72.231 µM 1.04626149597428 0.138253370132902 no 492 0.147720158672737 159 672022 SGTC_704 1310-0270 142 µM 1.04415446078836 0.138734470266425 no 493 0.148206966158292 178 5718033 SGTC_466 geldanamycin 89.2 µM 1.04331247836775 0.138927038932765 no 494 0.148401796829308 138 5288382 HSP90 inhibitor. SGTC_1472 k841-0093 193 µM 1.04308592600294 0.13897888447709 no 495 0.148454249187192 175 X1472 SGTC_1795 st049545 62.3 µM 1.04241314502131 0.139132925174753 no 496 0.14861008734399 148 5291882 SGTC_2645 abamectin 100 µM 1.04084204625715 0.139493098128995 no 497 0.148974431154015 174 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels. SGTC_406 estrone 100 µM 1.03877055320593 0.139968954546885 no 498 0.149455729730124 169 5870 A steroid. SGTC_2797 7859098 81.82 µM 1.03772600021721 0.140209323639017 no 499 0.149698818343066 176 972681 SGTC_2280 7785178 200 µM 1.03723908664849 0.140321466342604 no 500 0.149812223071113 165 2954328 SGTC_999 SEC7.066 22.7 µM 1.0366421077103 0.140459041673203 no 501 0.149951340779851 194 740511 YDR170C SEC7 SGTC_353 1988-1175 58.3 µM 1.0366127777743 0.140465803191653 no 502 0.149958177936429 182 2788357 SGTC_2240 6690706 185.951 µM 1.0359232041458 0.140624836351231 no 503 0.150118985641161 149 805876 SGTC_1731 st035964 63 µM 1.03260469694427 0.141391877015008 no 504 0.150894464609238 185 6739575 SGTC_1481 3346-2004 36 µM 1.02867437459116 0.142303994429831 no 505 0.151816357739158 198 2770522 SGTC_2712 st079126 47.7 µM 1.02856641587336 0.142329104667195 no 506 0.151841733144707 177 3152970 SGTC_158 k038-0087 26.446 µM 1.02839696072383 0.142368524472601 no 507 0.151881568803573 184 X158 SGTC_1347 1493-0251 600 nM 1.02797145455481 0.142467541157406 no 508 0.151981627755444 175 3986378 SGTC_231 b-estradiol 524 µM 1.02584635234084 0.142962756557816 no 509 0.152482006704744 171 450 A steroid. SGTC_1696 st025591 34.7925 µM 1.02562792563505 0.143013722668518 no 510 0.152533499589775 153 2787147 SGTC_1138 3761-0006 1.03 µM 1.02513532022232 0.143128708718939 no 511 0.152649670933776 156 12061087 SGTC_2905 7799065 20.05 µM 1.02026291092233 0.144269410932524 no 512 0.153801894151933 173 1296806 SGTC_1128 3448-9350 235 µM 1.01772670058147 0.144865593477587 no 513 0.154403927310276 140 619386 SGTC_1806 st050005 60.3 µM 1.01486484409 0.145540314469378 no 514 0.155085129215528 180 5194765 SGTC_1754 st042065 16.137 µM 1.01389543314389 0.145769344477473 no 515 0.155316325380715 184 1126236 YIL048W NEO1 SGTC_2924 9010168 62.78 µM 1.01268482112659 0.146055699903404 no 516 0.155605365164184 170 2993929 SGTC_1591 genipin 88.4 µM 1.01246191088188 0.146108467759045 no 517 0.155658624774109 178 442424 A DNA cross-linking agent. SGTC_2111 5486399 200 µM 1.01160903388995 0.146310481100206 no 518 0.155862512381842 181 689674 SGTC_2459 5811157 9.22 µM 1.00807386075751 0.147149825072866 no 519 0.156709502609086 180 2870684 YBR192W RIM2 SGTC_1701 st028638 40.4 µM 1.00708411721541 0.147385393735673 no 520 0.156947176521686 160 3490878 SGTC_1974 st069448 26.9 µM 1.00412984761996 0.148090041080831 no 521 0.157658015187789 173 6323587 YNR016C ACC1 SGTC_2813 7971799 71.43 µM 1.00397443107371 0.148127173088876 no 522 0.15769546905714 179 2234054 SGTC_442 cape 100 µM 1.00388781861496 0.148147869177737 no 523 0.157716344349705 168 5281787 SGTC_3113 9123498 49.47 µM 1.00285362169099 0.148395140517189 no 524 0.157965746224817 219 8897275 SGTC_3045 9092950 49.47 µM 1.00274021458537 0.148422272376525 no 525 0.157993110673741 175 44120432 SGTC_1030 k029-0042 36.7 µM 1.00220929979119 0.148549334158595 no 526 0.158121258590049 175 6080581 SGTC_2648 atorvastatin 78.68 µM 1.00076549100313 0.148895243066117 no 527 0.158470098413386 173 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11 SGTC_107 0358-0022 2.6945 µM 0.999116959647481 0.149290857164687 no 528 0.158869018184901 167 521106 YGL093W | YPR107C SPC105 | YTH1 SGTC_1997 st073024 93.8 µM 0.99880829768063 0.149365007712101 no 529 0.158943782822942 177 686268 SGTC_1603 st002045 67.8 µM 0.996098504549373 0.150017042634221 no 530 0.159601143206544 177 5887985 SGTC_1203 3992-3522 103 µM 0.992825826967091 0.150807046227788 no 531 0.160397420690981 198 5322312 SGTC_1820 st053765 18.6 µM 0.987455984451374 0.152109282410034 no 532 0.161709575289805 188 3690829 SGTC_779 1360-0071 233 µM 0.98615878902384 0.152424980767225 no 533 0.162027599306858 197 7566 SGTC_502 l-744,832 89.3 µM 0.983400884785395 0.153097615806553 no 534 0.162705087503051 179 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.  SGTC_100 0086-0128 49.5915 µM 0.982088181559577 0.153418465692909 no 535 0.163028203659736 195 93297 SGTC_1943 st076331 65.2 µM 0.980437844075581 0.153822471417088 no 536 0.163435018439041 187 24208415 SGTC_2655 perillic acid 100 µM 0.978724591444851 0.154242623179409 no 537 0.163858038983676 183 5702197 An apoptosis inducer. SGTC_2545 solidagenone 89.61 µM 0.978015074877989 0.154416844440575 no 538 0.164033434154475 146 6708572 An anti ulcer agent SGTC_3222 9128301 49.47 µM 0.977462175736444 0.15455269856887 no 539 0.164170197312636 194 4911358 SGTC_1984 st072354 53.1 µM 0.977335637151736 0.154583801763022 no 540 0.16420150784176 199 5762938 SGTC_845 0330-0138 4.51 µM 0.97437228494041 0.155313376767481 no 541 0.164935862709665 201 9039800 SGTC_2395 5646831 180.19 µM 0.974358965625857 0.155316661093998 no 542 0.164939168192268 192 6808628 SGTC_3129 9127257 49.47 µM 0.969751475391165 0.156455543802991 no 543 0.166085192734143 178 837894 SGTC_1826 st055655 41.6 µM 0.967476795039018 0.157019823444422 no 544 0.166652868033367 176 676168 SGTC_640 3381-0960 37.1 µM 0.965039528886743 0.157625919530027 no 545 0.16726250661554 204 1745025 SGTC_1067 clotrimazole 1.36 µM 0.964422014153778 0.157779725998694 no 546 0.167417194844034 198 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_2597 laccaic acid a 100 µM 0.962979718025818 0.158139347398099 no 547 0.167778850827086 188 5491415 A textile dye. SGTC_1152 3909-8331 15.9 µM 0.959193489197745 0.159085961684006 no 548 0.168730639913084 182 16001939 SGTC_1015 4130-4525 82 µM 0.959046407741742 0.159122809015077 no 549 0.168767683397784 199 1363237 SGTC_3290 9121031 71.43 µM 0.95868255925911 0.1592139855561 no 550 0.168859343614366 191 17014854 SGTC_496 calpeptin 138 µM 0.958609632367871 0.159232264371264 no 551 0.168877719105033 172 73364 A calpain inhibitor. SGTC_2318 6029776 164 µM 0.956197230250413 0.159837697384684 no 552 0.16948629951043 192 818325 SGTC_552 k242-0005 476 µM 0.953093252935361 0.160618905217522 no 553 0.170271412179954 210 4088318 SGTC_2842 9000675 19.48 µM 0.951648122812109 0.160983464399193 no 554 0.170637733599073 208 2989072 SGTC_2681 menadione 3.18 µM 0.950294328233239 0.161325472154332 no 555 0.17098136000959 218 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_128 0906-2981 13.371 µM 0.94726836301738 0.162091630867793 no 556 0.171751023817964 224 6740226 SGTC_476 mead acid 10 µM 0.947204487652281 0.162107829276243 no 557 0.171767294532024 188 5312531 An omega 9 fatty acid. SGTC_1058 3448-5425 97.3 µM 0.942849967206685 0.163214594847662 no 558 0.172878824749699 213 7279705 SGTC_698 k064-0052 127 µM 0.941938459623734 0.163446887955382 no 559 0.173112074075547 218 5088751 SGTC_625 k213-0058 121 µM 0.941647292385121 0.163521135686165 no 560 0.173186624248486 212 3655420 SGTC_832 4083-0019 164 µM 0.941615360016557 0.163529279782033 no 561 0.173194801424606 219 1990758 SGTC_852 0418-0143 439 µM 0.938359076475238 0.164361151796707 no 562 0.174029954670619 202 5369229 SGTC_1315 1237-0019 3.69 µM 0.937097763536021 0.164684111120819 no 563 0.174354135876424 194 825140 SGTC_2458 5808907 16.39 µM 0.936522011036656 0.164831669197219 no 564 0.174502242576786 221 2731747 SGTC_617 3770-0098 35 µM 0.93574828188723 0.165030101007533 no 565 0.174701402638908 199 5962639 SGTC_330 1488-0319 80.1 µM 0.935575376677737 0.165074465687564 no 566 0.174745928646538 210 6846614 SGTC_2889 9059656 51.95 µM 0.935514528833423 0.165090080096733 no 567 0.174761599706237 203 3949838 SGTC_747 3448-8087 38.7 µM 0.933651040162268 0.165568740397062 no 568 0.175241963921277 190 5168703 SGTC_980 1473-0395 201 µM 0.933471362765089 0.165614940174571 no 569 0.175288324811153 235 768876 SGTC_1934 st074720 32.6 µM 0.929937680481494 0.16652523666322 no 570 0.1762016760238 188 17250992 SGTC_1952 st077036 64.1 µM 0.929927557506066 0.166527849029586 no 571 0.176204296829433 187 2937007 SGTC_1900 st060200 72.8 µM 0.926152822611867 0.16750381271844 no 572 0.177183283003336 195 688945 SGTC_3053 9095903 49.47 µM 0.926055774181618 0.167528953235368 no 573 0.177208497951905 248 17174018 SGTC_812 4251-0442 148 µM 0.925784438550608 0.167599255967291 no 574 0.177279007912866 206 5723007 SGTC_2483 5729050 27.16 µM 0.92513784812633 0.167766863345321 no 575 0.177447103931599 194 2865180 SGTC_1460 k062-0059 9.15 µM 0.924627546959628 0.167899218374892 no 576 0.177579839446361 193 1373085 SGTC_2373 9071805 200 µM 0.922316892640027 0.168499365687988 no 577 0.178181652576653 214 10149009 SGTC_2349 9023730 187.07 µM 0.921942425620429 0.168596755896119 no 578 0.178279303942629 188 4126287 SGTC_1414 3917-0015 5.4 µM 0.920793488405308 0.168895793662071 no 579 0.178579127642758 196 6618702 SGTC_1881 5652484 16 µM 0.918685447716247 0.169445346086227 no 580 0.179130061800123 194 2255129 SGTC_2073 5212005 126 µM 0.917904479458036 0.169649230378866 no 581 0.179334438150556 212 691789 SGTC_769 0302-0231 76 µM 0.917566721078757 0.169737456348149 no 582 0.179422873603062 231 571869 YER009W NTF2 SGTC_403 arphamenine a 50 µM 0.917404774336503 0.169779768941218 no 583 0.179465285925675 215 5487158 An arginine aminopeptidase inhibitor. SGTC_2815 7968870 71.43 µM 0.915345123861798 0.17031849356144 no 584 0.180005238596833 188 2977326 YHR190W ERG9 SGTC_2095 5432005 200 µM 0.911661220432648 0.171284787306111 no 585 0.180973542060711 217 783734 SGTC_2893 9048488 25.97 µM 0.908445553030125 0.172131121221753 no 586 0.181821433844981 201 6467338 SGTC_1518 st038567 90.8 µM 0.907655787956355 0.172339387633413 no 587 0.182030054796949 218 77966 SGTC_2276 7947513 42.08 µM 0.906308357488262 0.172695085127672 no 588 0.182386331581705 190 2105100 SGTC_2225 6654152 15.4 µM 0.905584494391776 0.1728863651164 no 589 0.182577909436949 210 97582 YGR029W | YLR033W ERV1 | RSC58 SGTC_1715 st032160 10.2275 µM 0.905526513798329 0.172901692259323 no 590 0.182593260035089 186 5289825 SGTC_830 4076-0286 57.8 µM 0.905289915190966 0.172964245966591 no 591 0.182655908834294 207 6866659 SGTC_2244 6635614 200 µM 0.904811847605382 0.173090685042704 no 592 0.182782537008629 187 836499 SGTC_1493 4348-0038 111 µM 0.904777925759555 0.173099658911955 no 593 0.182791524140839 239 800424 SGTC_2973 9094665 17.96 µM 0.904422829462949 0.173193615801443 no 594 0.182885618636941 225 25237061 YIL048W NEO1 SGTC_2972 9093619 59.92 µM 0.90104279558642 0.174089583006514 no 595 0.183782783038288 177 25236256 SGTC_408 cantharidin 100 µM 0.900792043263007 0.174156168721801 no 596 0.18384944943714 194 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM 0.900309887348421 0.174284247696535 no 597 0.18397768039296 234 91467 include heat shock SGTC_1349 flufenamic acid 69 µM 0.899186588053074 0.174582870850633 no 598 0.184276641486953 217 3371 A non-steroidal anti-inflammatory. SGTC_2832 7992762 51.95 µM 0.894929095505996 0.175717649942002 no 599 0.18541249608402 216 2985177 SGTC_1322 1348-1070 12 µM 0.894386651537597 0.175862566188207 no 600 0.185557525980682 212 6758089 SGTC_147 4466-0538 29.23 µM 0.892025236022858 0.17649431018873 no 601 0.186189703034535 228 6742687 YHR072W ERG7 SGTC_2399 5884133 200 µM 0.888270353170857 0.17750179709405 no 602 0.187197671498653 209 722445 SGTC_2170 morpholine 200 µM 0.888208845162221 0.177518330703272 no 603 0.187214210876305 194 121171 Reacts with secondary amines. SGTC_2216 7189485 200 µM 0.888117577610628 0.177542865592956 no 604 0.18723875419931 199 731273 SGTC_974 1326-0144 138 µM 0.886541859414826 0.177966793541008 no 605 0.187662803988121 218 5411856 SGTC_2665 lovastatin 100 µM 0.885399826268041 0.17827444238356 no 606 0.187970513040972 219 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1 SGTC_1452 4194-0072 190 µM 0.885111666713157 0.178352121731851 no 607 0.188048203847824 207 1343545 SGTC_65 0798-0905 34.986 µM 0.884936940014806 0.17839923329994 no 608 0.188095321630779 204 3602145 SGTC_880 0833-0487 87.2 µM 0.884867308218368 0.178418010309206 no 609 0.188114100962537 226 76075 SGTC_2714 st079313 56.9 µM 0.883928556235403 0.178671277036657 no 610 0.188367390416851 187 2939799 SGTC_828 2074-0507 139 µM 0.88335458330019 0.178826241164623 no 611 0.188522360563467 213 X828 SGTC_1857 st056007 79.3 µM 0.882667894359314 0.179011748049239 no 612 0.188707866790292 199 619834 SGTC_3097 9117246 49.47 µM 0.881617677569169 0.179295694962698 no 613 0.18899179612843 207 16423892 SGTC_432 NS 1619 61.3 µM 0.880932153378608 0.179481192697206 no 614 0.189177271575302 197 4552 A K+/calcium channel activator. SGTC_204 PMA1.184 62.41 µM 0.87978563977397 0.179791700219207 no 615 0.189487722715194 225 2252213 YGL008C PMA1 SGTC_2306 7482397 179.52 µM 0.878639789101646 0.180102365148081 no 616 0.189798307381391 224 891448 SGTC_201 4262-0159 12.803 µM 0.878252759636971 0.180207373307216 no 617 0.189903283025579 203 1341029 SGTC_153 4077-0274 519.67 µM 0.877730926566427 0.180349016966671 no 618 0.190044878521803 227 3121976 SGTC_58 0957-0393 9 µM 0.876878826033093 0.180580456830035 no 619 0.190276229062752 236 6997992 SGTC_203 k066-0004 30.888 µM 0.876032295034205 0.180810568303578 no 620 0.190506238676292 235 6795412 SGTC_319 1348-1596 45.5 µM 0.875855995998407 0.180858514568612 no 621 0.190554162081605 212 5380505 SGTC_1870 st057514 26.5 µM 0.875566889404372 0.180937157211157 no 622 0.190632766008458 218 5393161 SGTC_490 phenamil 164 µM 0.875538927620572 0.180944764499114 no 623 0.190640369470935 208 4755 Irreversibly blocks amiloride-sensitive Na+ channels. SGTC_83 0170-0301 39.027 µM 0.874518554968132 0.18122250436767 no 624 0.190917959967194 204 3089716 SGTC_1149 3909-7961 23.3 µM 0.873938046222381 0.181380634778131 no 625 0.191075996901892 203 735261 SGTC_998 3996-0085 177 µM 0.872402050704314 0.181799456040514 no 626 0.191494541090511 207 715391 SGTC_1087 pterostilbene 9.05 µM 0.868003952112435 0.183002032035787 no 627 0.192696084552484 221 5281727 Similar to reservatol, lowers cholesterol. SGTC_736 0958-0254 92.6 µM 0.867263859932507 0.183204882904144 no 628 0.192898726762069 236 6812352 SGTC_2155 5570423 76 µM 0.867038991980991 0.183266544425515 no 629 0.192960322890368 218 797402 SGTC_3278 9139605 49.47 µM 0.866701604156638 0.183359084534624 no 630 0.193052763140524 233 7958859 SGTC_2260 7964312 200 µM 0.863129082049563 0.184340757269146 no 631 0.194033249913406 228 231951 SGTC_2465 5809242 33.21 µM 0.863119993927954 0.18434325870422 no 632 0.1940357480316 249 2731748 SGTC_3138 9097216 49.47 µM 0.862924948531934 0.184396948528877 no 633 0.194089366303574 240 25237486 SGTC_2912 7964298 10.93 µM 0.861932744980133 0.184670221354634 no 634 0.194362264270558 225 2975850 SGTC_1604 st002052 72.4 µM 0.861004353904302 0.184926146843695 no 635 0.194617822551385 213 6254834 YHR062C RPP1 SGTC_588 3970-1144 52.9 µM 0.860978305255374 0.184933330737577 no 636 0.194624995912606 186 1888707 SGTC_1426 4048-4480 71.7 µM 0.859609413845681 0.185311097976969 no 637 0.195002192002797 207 14224343 SGTC_2197 6588183 93.1375 µM 0.857673502925051 0.185846160490389 no 638 0.195536387623855 198 884136 SGTC_3092 9117248 49.47 µM 0.854034101409427 0.186854637930282 no 639 0.196543047405391 239 17141857 SGTC_1693 xanthone 101.9 µM 0.85329157940414 0.187060805831531 no 640 0.196748814278704 258 7020 An insecticide. SGTC_184 1494-0393 24.714 µM 0.852406088194424 0.187306854299002 no 641 0.196994371112211 239 3090647 SGTC_759 3486-0358 89.3 µM 0.852303932396555 0.187335252855101 no 642 0.197022712012832 245 875103 SGTC_1351 1496-0003 46.5 µM 0.851011074871527 0.187694887660661 no 643 0.197381600377843 228 3891978 SGTC_707 0865-0008 204 µM 0.845721265894134 0.189170794064905 no 644 0.198854128442537 235 723043 SGTC_171 k064-0041 9.68 µM 0.845563926708068 0.189214802337733 no 645 0.198898028238046 209 53325 SGTC_3243 9134147 49.47 µM 0.845412176044454 0.189257253454284 no 646 0.198940374292307 241 24282180 SGTC_995 3931-2021 34.6 µM 0.84368244100421 0.189741548177089 no 647 0.199423441056728 213 730143 SGTC_2231 micatex 6.853 µM 0.843435861030447 0.189810648154532 no 648 0.199492361429711 233 20737 An antifungal of unknown mechanism. SGTC_966 1300-0360 30.2 µM 0.840655097709297 0.190590982151309 no 649 0.20027059120638 237 70588 SGTC_281 1672-3440 14.9 µM 0.840289093717635 0.190693836152698 no 650 0.200373157466799 223 6833000 SGTC_931 2812-0076 566 µM 0.83990881181558 0.190800738593598 no 651 0.200479758282641 226 3450959 SGTC_1910 st062352 60.4 µM 0.83958285457372 0.190892398891984 no 652 0.200571157886668 223 2245730 SGTC_1809 st050081 57.6 µM 0.839539032335426 0.190904723915913 no 653 0.200583447710509 246 5036894 SGTC_352 k048-0007 5.11 µM 0.83553062850875 0.192034152983447 no 654 0.201709504636876 255 6811911 SGTC_811 0416-0114 265 µM 0.833968641567557 0.192475371572763 no 655 0.202149327441672 227 6612453 SGTC_851 0394-0702 453 µM 0.83334956252559 0.192650415830597 no 656 0.202323805792556 242 762646 SGTC_1416 3966-0321 25.3 µM 0.832355210954852 0.192931771730354 no 657 0.202604237644154 230 582530 YLR208W SEC13 SGTC_1901 st060216 58.6 µM 0.829898660421214 0.193627937983414 no 658 0.203298041172614 218 688792 SGTC_2334 9017922 200 µM 0.829563022327196 0.193723173870304 no 659 0.203392945405579 221 3163164 SGTC_433 pimozide 108 µM 0.829470828342944 0.193749338521564 no 660 0.203419018585159 216 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic SGTC_2732 terfenadine 20 µM 0.828337194152783 0.194071239975992 no 661 0.203739782174093 251 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.  SGTC_1432 4049-0298 68.4 µM 0.826644251489086 0.194552566228836 no 662 0.2042193639845 229 741646 SGTC_1053 3366-3204 134 µM 0.823850425828308 0.195348475271995 no 663 0.205012275725811 250 3632071 YPR165W RHO1 SGTC_33 0986-0033 35.816 µM 0.82379710218899 0.195363685398606 no 664 0.205027427208841 199 2848082 SGTC_101 0490-5701 117.494 µM 0.823669936826998 0.195399961168766 no 665 0.205063562909459 207 4661669 SGTC_2017 5132927 60.65 µM 0.822758149404719 0.195660181625582 no 666 0.205322770085266 208 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis SGTC_972 1319-0219 195 µM 0.820586747364617 0.196280737565949 no 667 0.205940849490161 244 23903702 SGTC_1207 2099-0101 141 µM 0.81840105242959 0.196906581725698 no 668 0.206564110495646 233 5837381 SGTC_2660 2',4'-dihydroxychalcone 17.14 µM 0.818053753847743 0.197006137090137 no 669 0.20666324705627 212 5357218 A potent inhibitor of glutathione S-transferases. SGTC_2838 9002687 71.43 µM 0.815508289728023 0.197736740254877 no 670 0.207390710708934 239 6457060 SGTC_301 4119-0100 24.5 µM 0.815025041077415 0.197875627750279 no 671 0.207528988262282 242 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1 SGTC_2115 tiliquinol 12.7705 µM 0.814573313141192 0.198005509350034 no 672 0.207658295686416 238 71208 A bioactive hydroxyquinoline. SGTC_3158 9100007 49.47 µM 0.813548507969091 0.198300353943024 no 673 0.207951823284705 234 19297233 SGTC_1289 0976-0073 69.1 µM 0.81342691829191 0.198335353835499 no 674 0.207986665593253 228 3391136 SGTC_3051 9093778 49.47 µM 0.812579574100779 0.198579367479496 no 675 0.208229573234657 264 17217378 SGTC_2319 6033012 152.6 µM 0.81239924551835 0.198631320898152 no 676 0.208281289512845 240 847246 SGTC_2998 9066762 71.4286 µM 0.810326560230963 0.199229058598202 no 677 0.208876257030218 219 4945196 SGTC_1714 st033236 13.627 µM 0.80829832301126 0.199815025520815 no 678 0.209459433844392 257 2916566 SGTC_600 1495-0418 41.6 µM 0.807668591899792 0.199997168372086 no 679 0.209640694439607 249 5377768 SGTC_945 3381-0768 11.3 µM 0.807506004370745 0.20004421124956 no 680 0.20968750830094 245 1126236 YIL048W NEO1 SGTC_3302 9125395 16.351 µM 0.804634851119554 0.200876042742611 no 681 0.210515212329434 220 17599668 SGTC_436 n,n-dimethylsphingosine 3.3 µM 0.804614392714132 0.200881977396376 no 682 0.210521117007308 264 5282309 SGTC_2314 7727897 200 µM 0.803858392405864 0.201101354672591 no 683 0.210739380967035 218 900724 SGTC_1749 st037932 54.2 µM 0.803274736525823 0.201270819034567 no 684 0.210907978331346 244 594497 SGTC_2007 4011539 71.82 µM 0.803215234386449 0.201288100275863 no 685 0.210925170818262 218 45595301 SGTC_2332 7982454 138.89 µM 0.802973597486821 0.201358288162988 no 686 0.210994997579151 261 2981748 SGTC_2990 9074105 71.4286 µM 0.802895327405743 0.201381026294441 no 687 0.21101761849628 242 6502001 SGTC_1179 1021-1431 9.29 µM 0.797818119795551 0.202859284370458 no 688 0.212488022309089 265 2840958 SGTC_1713 st033146 12.748 µM 0.797368725297495 0.202990439684589 no 689 0.212618458604094 232 674619 SGTC_1556 plumbagin 1.48 µM 0.795237512250543 0.203613121177203 no 690 0.213237677396477 244 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_280 3448-3607 3.04 µM 0.792605248206023 0.204383766102132 no 691 0.214003925022718 208 626179 SGTC_878 0828-0289 13.7 µM 0.792235013488922 0.204492298408475 no 692 0.214111828144911 235 745350 YLR208W SEC13 SGTC_1592 4',5'-dihydroxyflavone 8.85 µM 0.79146154229215 0.204719147958914 no 693 0.214337354729038 241 688669 SGTC_480 am 92016 50 µM 0.790453354024913 0.205015061739333 no 694 0.214631526782724 276 2129 K+ channel blocker. SGTC_1834 st055981 52.8 µM 0.790091714741141 0.205121268571522 no 695 0.214737104082805 230 471719 YDL150W RPC53 SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM 0.789340840290568 0.205341891038751 no 696 0.214956411399762 248 23847180 SGTC_1682 st012968 530 nM 0.789306166701553 0.205352082260904 no 697 0.214966541628962 211 24207270 SGTC_2113 5491891 107.031 µM 0.788908264199937 0.205469054819188 no 698 0.215082812593698 248 789979 SGTC_451 chloral hydrate 100 µM 0.786969067720673 0.206039692091491 no 699 0.215649986923841 253 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1 SGTC_918 glabranin 770.725 nM 0.786040097311634 0.206313388010875 no 700 0.215921998223893 215 124049 Also referred to as licorice root. SGTC_1206 3978-0017 132 µM 0.785765551245775 0.206394316789453 no 701 0.216002425944884 232 3873677 SGTC_2206 7254556 146.969 µM 0.784320167642859 0.206820687003146 no 702 0.216426134276874 209 4398905 SGTC_1394 3474-0001 65.7 µM 0.783776305399447 0.206981254520051 no 703 0.216585689745782 208 5017666 YIL048W NEO1 SGTC_850 0388-0143 75.9 µM 0.783491491159966 0.207065371255998 no 704 0.216669274204198 237 67273 SGTC_717 1532-0246 73.2 µM 0.783037400147689 0.207199523834298 no 705 0.21680257490881 231 9561992 SGTC_94 0334-0113 514.748 µM 0.782121500651923 0.207470265326232 no 706 0.217071586049253 255 6795178 SGTC_3066 9117245 49.47 µM 0.777691615980349 0.208782695413764 no 707 0.218375417991874 237 17176980 SGTC_912 3474-0017 2.18 µM 0.775846656029188 0.209330736652174 no 708 0.218919766191407 240 3360550 SGTC_2118 5526350 200 µM 0.77532264881588 0.209486546068798 no 709 0.219074514678612 246 743594 SGTC_1111 tnp00062 510.699 nM 0.775242630853745 0.209510344782796 no 710 0.219098150916003 237 676306 SGTC_2529 gangaleoidin 93.61 µM 0.771387752764911 0.210658734441601 no 711 0.220238566116779 262 4565183 SGTC_844 0330-0132 15.3 µM 0.771292115065905 0.21068727231387 no 712 0.220266902480111 243 2828079 SGTC_866 0495-0101 262 µM 0.770833803087289 0.210824062082911 no 713 0.220402724119246 236 635694 SGTC_1385 3091-4834 14.1 µM 0.769389349291759 0.211255520610546 no 714 0.22083110471568 223 4072814 SGTC_2421 5690543 90.72 µM 0.768719538325447 0.211455768666807 no 715 0.221029911739191 255 3397993 SGTC_1764 st044502 93.5 µM 0.767784568882272 0.211735474833043 no 716 0.221307591827782 233 8407 SGTC_2190 6049624 200 µM 0.767583184397143 0.21179574949674 no 717 0.221367427866949 252 2265554 SGTC_1908 st060353 56.5 µM 0.767353032286344 0.211864646643996 no 718 0.221435822766841 273 4227716 SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM 0.766915074705667 0.21199578757251 no 719 0.221566005121201 236 1241132 A phosphatase inhibitor. SGTC_2564 betulinic acid 100 µM 0.764582151592597 0.212695151828383 no 720 0.222260200342017 261 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14 SGTC_2656 pseudo-anisatin 100 µM 0.762425873495823 0.213342757786651 no 721 0.222902934442088 286 6708809 A neurotoxin. SGTC_3355 9151058 44.0485 µM 0.762382520661638 0.213355789941183 no 722 0.22291586771734 249 17015728 SGTC_3106 9121286 49.47 µM 0.761149979302494 0.213726494309771 no 723 0.22328374558175 228 15943471 SGTC_2098 5376439 882.5 nM 0.76074900515154 0.213847173826651 no 724 0.223403499189464 236 2844116 SGTC_2440 5628896 157.78 µM 0.760689139918568 0.213865194619595 no 725 0.223421381475784 267 5522048 SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM 0.759705012796499 0.21416156592952 no 726 0.223715465854946 249 2374 Ca(2+)-ATPase inhibitor. SGTC_1522 st012842 45.6 µM 0.758898373957565 0.214404664501005 no 727 0.223956675863115 250 3491067 YOR116C RPO31 SGTC_732 3970-1727 52.7 µM 0.75824868161953 0.214600580372198 no 728 0.224151061399031 263 1275699 SGTC_399 oxolinic acid 75 µM 0.756017176454315 0.215274286684901 no 729 0.22481944872907 245 4628 A DNA gyrase inhibitor. SGTC_28 pentachloropyridine N-oxide 1.606 µM 0.754214732363482 0.215819351560505 no 730 0.225360146355962 246 140250 A respiratory chain inhibitor. SGTC_1852 st056254 31.4 µM 0.753508934349217 0.216033004876667 no 731 0.225572072264111 253 442583 SGTC_1342 1486-1464 234 µM 0.753203084519276 0.216125627235387 no 732 0.225663943047033 264 3253938 SGTC_208 k072-0098 12.366 µM 0.751667643447627 0.216590961573064 no 733 0.226125476665573 257 5948901 SGTC_1977 st070720 65.3 µM 0.751618361727841 0.216605906599172 no 734 0.226140298940056 228 682188 SGTC_869 0564-0080 44.1 µM 0.751240767866823 0.216720434371365 no 735 0.226253884620399 226 6843321 SGTC_59 0330-0160 1.33 µM 0.750759081671946 0.216866585147869 no 736 0.226398829549813 255 4293482 SGTC_709 3807-1509 243 µM 0.747666701072567 0.217806215660228 no 737 0.227330610548836 280 1886677 YPL242C IQG1 SGTC_2683 piperine 63.03 µM 0.747650575617089 0.217811121582111 no 738 0.22733547504845 265 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_1688 st021091 57.6 µM 0.747298660412713 0.217918202244527 no 739 0.227441650461041 260 3656366 SGTC_777 1315-0167 517 µM 0.745712111239006 0.218401333764485 no 740 0.22792067071505 252 4221767 SGTC_3023 9089636 49.47 µM 0.745073273346123 0.218596044980926 no 741 0.228113712575673 265 17249241 SGTC_930 2810-3379 265 µM 0.744153203972865 0.21887664819687 no 742 0.228391897499565 270 1015764 SGTC_1663 st014140 55.4 µM 0.741830883707258 0.219585831504752 no 743 0.229094903099039 244 4207120 SGTC_962 1254-0300 21.5 µM 0.741587332470627 0.219660282844172 no 744 0.229168700432791 228 7340576 SGTC_2026 5148700 152 µM 0.740728134377629 0.219923047416322 no 745 0.229429148521115 258 79838 SGTC_5 0352-0601 109.883 µM 0.740527999631779 0.219984279589598 no 746 0.229489839032632 245 762456 SGTC_1244 0416-0015 52.5 µM 0.740488561513495 0.21999634702228 no 747 0.229501799633986 244 96201 SGTC_923 1900-2434 73.3 µM 0.740377703915746 0.220030269706266 no 748 0.229535421859741 277 5910570 SGTC_2778 tioconazole 65.09 nM 0.738398804939861 0.220636322120574 no 749 0.230136070292952 258 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_336 4111-0029 111 µM 0.738201680410845 0.220696745291045 no 750 0.230195950947944 257 3131175 SGTC_1332 1480-0653 17.5 µM 0.738176882749048 0.220704347011844 no 751 0.23020348436797 246 5749438 SGTC_803 4488-1585 147 µM 0.736160422126863 0.221322994551901 no 752 0.230816537535003 241 747204 SGTC_3159 9100096 49.47 µM 0.735086118662347 0.221652993991468 no 753 0.231143523888411 249 25236875 SGTC_300 r073-0011 5.04 µM 0.73479518383762 0.221742410328384 no 754 0.231232120344411 253 2735780 SGTC_868 0527-0199 213 µM 0.734179461176323 0.221931715378188 no 755 0.231419684750027 252 2849450 SGTC_3065 9113888 49.47 µM 0.733272286745565 0.222210795885732 no 756 0.23169618711376 254 16648368 SGTC_3031 9088762 49.47 µM 0.732846277506433 0.222341921204483 no 757 0.23182609615748 259 205253 SGTC_1963 st076565 50.3 µM 0.731783380270033 0.222669272545688 no 758 0.232150397333987 280 4914280 SGTC_422 cantharidin 155 µM 0.731577624116897 0.22273267309653 no 759 0.232213204867854 272 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_2317 5986382 200 µM 0.731559964954712 0.222738114971394 no 760 0.232218595807866 287 877883 SGTC_2503 beta-caryophyllene alcohol 24.72 µM 0.731370206696015 0.222796595952943 no 761 0.23227652907721 265 61125 An anti-inflammatory. SGTC_2635 hydroquinidine 100 µM 0.731071547553657 0.222888656463873 no 762 0.232367726114481 251 442912 An experimental heart treatment. SGTC_1717 st033143 58.0435 µM 0.72832306236279 0.223736882996777 no 763 0.233207923998586 257 674616 SGTC_2205 7238770 200 µM 0.727154540231147 0.224098062853857 no 764 0.233565645463493 249 279867 SGTC_2028 5153890 36.43 µM 0.725581890344712 0.224584677402511 no 765 0.23404756315133 264 2830968 YPR165W RHO1 SGTC_1644 st010134 20.9 µM 0.725066064200654 0.224744416499501 no 766 0.234205751088849 270 3818134 SGTC_1196 1588-0294 184 µM 0.724996585861059 0.224765937212512 no 767 0.23422706247091 259 6144269 SGTC_2233 sulbentine 40.3845 µM 0.723390085201407 0.225263871884325 no 768 0.234720130429319 260 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58 SGTC_2913 7966556 36.57 µM 0.722738844169943 0.225465901782266 no 769 0.234920172994543 249 2976516 SGTC_3080 9117754 49.47 µM 0.722706631402822 0.225475897582561 no 770 0.234930070277368 259 9550191 SGTC_1666 st014829 29 µM 0.722666469969116 0.225488360249508 no 771 0.234942410088538 261 3858230 SGTC_22 0964-0034 14.468 µM 0.721674554679281 0.225796289454793 no 772 0.235247294898517 279 138402 SGTC_3021 9087658 49.47 µM 0.720042491392244 0.226303462816583 no 773 0.235749416950691 251 25237042 SGTC_1914 st062367 72.6 µM 0.72001174018007 0.226313025111129 no 774 0.235758883565294 267 978205 SGTC_706 4262-0057 46.9 µM 0.719860908870351 0.226359930418017 no 775 0.235805319302854 264 883298 SGTC_902 1120-0002 2.07 µM 0.719287844486155 0.226538191220247 no 776 0.235981791950259 258 3280475 SGTC_2668 2',4'-dihydroxychalcone 15.08 µM 0.718930428577028 0.226649411247644 no 777 0.236091893443293 288 5357218 A potent inhibitor of glutathione S-transferases. SGTC_564 3555-0129 330 µM 0.718846097264054 0.226675657803906 no 778 0.23611787571745 259 563260 SGTC_2814 7977482 42.97 µM 0.718325779994253 0.226837634834679 no 779 0.236278219050132 266 6456762 SGTC_3132 9126706 49.47 µM 0.718182032305643 0.226882395624462 no 780 0.236322527558888 273 850858 SGTC_2037 5169046 200 µM 0.717829834924659 0.226992085454002 no 781 0.23643110753015 249 5718022 SGTC_2606 farnesol 9.78 µM 0.717513876708815 0.22709051424848 no 782 0.236528538584692 282 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_924 2046-0044 21.3 µM 0.715740855401909 0.227643300368833 no 783 0.237075689322119 260 3623589 SGTC_1477 0139-0234 16 µM 0.714197567802102 0.228125077005455 no 784 0.237552510321227 264 620880 SGTC_2478 5763493 32.33 µM 0.713514051937646 0.228338636997465 no 785 0.237763860477225 265 1365576 YLR208W SEC13 SGTC_3123 9126162 49.47 µM 0.713096454346879 0.22846916786433 no 786 0.23789303669978 251 25239884 SGTC_1283 0922-0125 16.4 µM 0.710682310990993 0.229224591613628 no 787 0.238640561801462 248 3360884 SGTC_346 4513-0042 7.16 µM 0.710503158852968 0.22928070693068 no 788 0.23869608638263 251 2827372 SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM 0.710095881558319 0.229408305897819 no 789 0.238822340038643 277 279621 SGTC_364 0083-0097 67.7 µM 0.709338667544272 0.229645644926128 no 790 0.239057169153059 259 5207356 SGTC_2728 chlorpromazine 9.18 µM 0.709150345607858 0.229704693373587 no 791 0.239115591619023 311 2726 A thorazine and dopamine antagonist. SGTC_1241 0364-0022 50.8 µM 0.7069068237254 0.230408804623897 no 792 0.239812191580714 266 4563895 SGTC_643 k048-0106 28.4 µM 0.705821962990285 0.23074971174168 no 793 0.240149430964938 273 6763920 SGTC_566 0958-0068 16.5 µM 0.705816457828905 0.230751442404215 no 794 0.240151142956199 269 6815365 SGTC_677 0929-0063 136 µM 0.704760446206179 0.231083555785287 no 795 0.240479663710111 296 1539583 SGTC_1554 st069299 38.7 µM 0.702940427096199 0.231656573473284 no 796 0.241046437893386 243 24207999 SGTC_2345 9052315 157.45 µM 0.702479984715507 0.231801665282642 no 797 0.241189939806955 269 6469265 SGTC_2304 7443016 91.4 µM 0.702150314195431 0.231905580147809 no 798 0.241292713756479 279 939854 SGTC_842 0271-0008 11.1 µM 0.699627096914972 0.232701777634075 no 799 0.242080107874112 253 1221709 SGTC_1816 st051957 91.6 µM 0.699092376949001 0.232870702617659 no 800 0.242247151100849 275 674121 SGTC_1883 5-benzylidenerhodanine 20 µM 0.69908322977837 0.232873592920227 no 801 0.242250009164068 253 1273210 SGTC_327 1273-0057 3.96 µM 0.698963550581639 0.232911410721902 no 802 0.24228740500222 266 3108138 SGTC_417 st075190 100 µM 0.694953106418722 0.234180654190739 no 803 0.243542344880071 283 222757 SGTC_2464 5717415 7.67 µM 0.693895057594427 0.234516147574827 no 804 0.243874011662953 258 5285744 SGTC_76 0433-0009 400.328 µM 0.692397412492068 0.234991485363701 no 805 0.244343895161412 284 2841569 SGTC_3332 9141069 11.198 µM 0.692309446775575 0.235019421356415 no 806 0.244371509412525 274 17332883 SGTC_1228 0124-0032 52.5 µM 0.692069189790527 0.235095731082304 no 807 0.24444693960012 272 X1228 SGTC_3184 9108758 49.47 µM 0.692007830953678 0.235115221891596 no 808 0.244466205602686 279 902885 SGTC_1044 1222-0021 1.78 µM 0.691410213775664 0.235305103361965 no 809 0.244653893629317 269 4306703 SGTC_2724 maprotiline 69.64 µM 0.689247588608451 0.23599294327971 no 810 0.245333737035621 276 4011 A tricyclic antidepressant. SGTC_2153 5569715 200 µM 0.689014519227913 0.236067138910606 no 811 0.245407065351877 270 2054701 SGTC_1439 4092-1168 46 µM 0.686876821421734 0.236748255788584 no 812 0.246080177181214 288 2886240 SGTC_324 1315-0088 19.6 µM 0.685275061225894 0.237259318826573 no 813 0.246585182891909 282 6787421 SGTC_3298 9116858 71.43 µM 0.680103447690478 0.238913520362994 no 814 0.248219480800396 301 2506942 SGTC_3281 9140613 49.47 µM 0.679940835349034 0.238965635912308 no 815 0.248270961939242 256 16013766 SGTC_1574 spiramycin 23.7 µM 0.679045383163625 0.239252730270202 no 816 0.248554553441911 286 6419898 An antibiotic and protein synthesis inhibitor. SGTC_567 1080-0542 68.4 µM 0.677883740709584 0.239625449545444 no 817 0.248922704945084 246 5950415 SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM 0.677462653656502 0.239760635830563 no 818 0.249056228856153 280 688761 SGTC_3174 9107204 49.47 µM 0.676115305095543 0.240193469660718 no 819 0.249483720044359 288 3938802 SGTC_629 3448-6466 76.7 µM 0.675616309025258 0.240353879443898 no 820 0.249642142048873 287 573744 SGTC_329 k048-0121 21.3 µM 0.67530128873804 0.240455177490885 no 821 0.249742182659586 265 6832902 SGTC_3167 9103034 49.47 µM 0.674598595319551 0.240681219615393 no 822 0.249965412839401 276 5127859 SGTC_328 k915-0120 63.5 µM 0.67446554453793 0.240724032354143 no 823 0.250007692053878 260 6624543 SGTC_1192 1488-0095 21.4 µM 0.673788229399624 0.240942041318504 no 824 0.25022297960539 290 915875 SGTC_1411 3909-8223 150 µM 0.673333830154164 0.241088360005256 no 825 0.250367467457932 284 X1411 SGTC_3292 9120825 59.784 µM 0.673115906865468 0.241158549462278 no 826 0.250436777424811 283 24824900 SGTC_1606 st000094 49.2 µM 0.672986933780933 0.241200094773827 no 827 0.250477801787198 255 1242210 SGTC_1451 4152-0210 104 µM 0.672197833924202 0.241454367381015 no 828 0.250728879892982 290 659563 SGTC_1368 1852-0141 284 µM 0.671953044477804 0.241533275760836 no 829 0.250806794793027 288 2838987 SGTC_212 3807-4682 38.772 µM 0.671897585233995 0.241551155107334 no 830 0.250824448893142 277 3125501 YBL034C STU1 SGTC_2669 eugenol 100 µM 0.670142346617169 0.24211739260131 no 831 0.251383526105541 255 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism. SGTC_2245 6637752 200 µM 0.669183107372663 0.242427145689644 no 832 0.251689340351521 287 681890 SGTC_2097 5376186 200 µM 0.668995874575644 0.242487631068209 no 833 0.251749054789836 268 742755 SGTC_697 0508-1955 564 µM 0.66814654665202 0.242762108266199 no 834 0.252020026134756 275 6243113 SGTC_1478 0453-0656 35.7 µM 0.666819189084408 0.243191406798494 no 835 0.252443817041999 296 5258496 SGTC_2338 7999974 200 µM 0.666159844201174 0.243404806856565 no 836 0.252654468320924 296 315925 SGTC_897 1000-0139 31.4 µM 0.666042284267855 0.243442866304898 no 837 0.252692036764331 283 6151020 SGTC_2671 danthron 100 µM 0.665757591301811 0.243535047567248 no 838 0.252783027836055 283 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin. SGTC_1310 1188-0297 994 nM 0.665024444098252 0.243772521423565 no 839 0.253017429312434 268 1588352 SGTC_1386 3228-0095 33.8 µM 0.663657785691597 0.244215529487438 no 840 0.253454681792106 277 870181 SGTC_2684 capsaicin 100 µM 0.662548071067036 0.24457556721266 no 841 0.253810018871183 296 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_2326 6164455 177.58 µM 0.66242692672699 0.244614888792267 no 842 0.253848825821053 283 2888790 SGTC_3229 9132204 49.47 µM 0.661080190805054 0.24505224766525 no 843 0.25428044412681 284 17682924 SGTC_25 0118-0223 35.662 µM 0.660634206105111 0.245197175969299 no 844 0.254423463484581 290 5333628 SGTC_1955 wogonin 32.4 µM 0.66043295440344 0.245262590313863 no 845 0.25448801512514 259 5281703 A flavanone. SGTC_556 4058-0063 51.5 µM 0.660194286408995 0.24534017851464 no 846 0.254564579192211 280 6615692 SGTC_2621 lithochol-11-enic acid 100 µM 0.658155097638286 0.246003632729837 no 847 0.255219237268138 297 6708711 SGTC_130 0136-0219 337.655 µM 0.657770447988922 0.246128887098495 no 848 0.255342823219498 323 234244 SGTC_1034 k072-0165 12.7 µM 0.656914266692103 0.246407810180862 no 849 0.255618022120098 298 5835461 SGTC_398 bronopol 33.3 µM 0.656253845423144 0.246623075072851 no 850 0.255830404443516 272 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them. SGTC_2563 tomatine 8.54 µM 0.655712757995986 0.246799518035889 no 851 0.256004479276687 320 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties. SGTC_1316 1272-0050 65.9 µM 0.655002699329172 0.247031163248168 no 852 0.256233008061309 297 7340392 SGTC_1293 1000-1278 195 µM 0.654341092252861 0.247247106552091 no 853 0.256446038625701 305 678847 SGTC_1374 2889-5571 141 µM 0.651892480492309 0.248047191274284 no 854 0.25723526805999 277 2853281 SGTC_102 gallobenzophenone 83.616 µM 0.651833085958833 0.24806661560252 no 855 0.257254427606732 277 70837 SGTC_1896 st058441 89 µM 0.650959657579618 0.248352354423068 no 856 0.257536264628041 278 688759 SGTC_836 0330-0104 1.35 µM 0.650124552875402 0.248625719781027 no 857 0.257805885298234 279 46494820 SGTC_2955 9076254 12.21 µM 0.648837885481773 0.249047214357438 no 858 0.258221583382863 270 16459619 SGTC_2145 5634607 200 µM 0.648358375174923 0.249204392537988 no 859 0.258376592987903 293 308662 SGTC_2962 9082311 13.18 µM 0.644366333490864 0.250514984890662 no 860 0.259668955223196 297 16459453 SGTC_133 0724-0033 378.92 µM 0.643488664139728 0.250803613808963 no 861 0.259953533987123 279 280309 SGTC_2926 9010726 65.15 µM 0.642726841246326 0.251054288313344 no 862 0.260200680607961 290 2994293 SGTC_1779 st039427 55 µM 0.641732028458597 0.251381826585878 no 863 0.260523594818369 314 1124498 SGTC_692 k241-0027 77.8 µM 0.640777475753347 0.251696321603184 no 864 0.260833634556005 280 3600480 SGTC_3102 9121669 49.47 µM 0.6400879745929 0.251923619682181 no 865 0.261057703277599 303 41905072 SGTC_2133 5320837 200 µM 0.637803166453971 0.25267759361898 no 866 0.261800909047738 293 2841355 SGTC_2761 levamisole 97.89 µM 0.636471437667334 0.253117604280516 no 867 0.262234595871242 296 26879 An alkaline phosphatase inhibitor. SGTC_209 4077-0173 175.592 µM 0.63639388798341 0.253143239543743 no 868 0.262259861805423 271 15993494 SGTC_99 0109-0120 622.8 µM 0.6360481384597 0.253257549080779 no 869 0.262372523273901 302 759414 SGTC_2943 9068529 45.32 µM 0.635568000260629 0.253416334360925 no 870 0.262529015993339 312 3270634 SGTC_3037 9091026 49.47 µM 0.635315134308314 0.253499980044353 no 871 0.262611452467624 294 25236398 YIL048W NEO1 SGTC_1364 1653-0028 37.6 µM 0.634836285951501 0.253658418323766 no 872 0.262767597433898 276 5718652 SGTC_1642 st009582 77.7 µM 0.634016547581467 0.253929768783145 no 873 0.263035011492733 310 6739311 SGTC_382 3229-0966 23.2 µM 0.633893779347914 0.253970420734976 no 874 0.263075072769039 309 5722370 SGTC_224 benfluorex 43.875 µM 0.633236179706239 0.254188228255826 no 875 0.263289711321747 308 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis. SGTC_2755 lomerizine 42.69 µM 0.63309947323051 0.254233519922953 no 876 0.263334343131704 290 3949 A calcium channel blocker. SGTC_1234 0326-0494 15.5 µM 0.631410228917441 0.25479352560095 no 877 0.263886164757818 302 1547813 SGTC_590 k048-0076 22.4 µM 0.630315272543302 0.255156862021473 no 878 0.264244166313574 305 6832814 SGTC_1575 cyproterone acetate 48 µM 0.628386349085264 0.255797589985807 no 879 0.264875438725591 314 9880 An androgen receptor antagonist and liver toxin. SGTC_2357 9067248 200 µM 0.625858512482839 0.25663852790478 no 880 0.265703874365949 308 9150235 SGTC_1405 3909-7894 12 µM 0.62555851795215 0.256738422861742 no 881 0.265802277252152 293 7104060 SGTC_1072 oxiconazole 14.9 nM 0.623816227544211 0.257318986776946 no 882 0.26637414061451 275 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_1619 st003326 88.7 µM 0.623565713114664 0.257402518964246 no 883 0.266456416888053 265 2849032 SGTC_2401 5128683 200 µM 0.623333197285561 0.257480062256823 no 884 0.266532793395803 309 708373 SGTC_1838 st055369 84.5 µM 0.622412860323892 0.257787110754049 no 885 0.26683521313154 282 676036 SGTC_2248 tofa 1.1 µM 0.622337616986562 0.257812222301748 no 886 0.266859945512548 297 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_2069 5228469 200 µM 0.621548993918193 0.25807549200986 no 887 0.267119234490999 315 2835210 SGTC_1247 0448-0043 5.84 µM 0.619941692571162 0.258612496214022 no 888 0.267648087686279 310 3089013 YGL099W LSG1 SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM 0.617543509527262 0.259414810657748 no 889 0.268438146017955 292 5379071 SGTC_2277 7947813 106.88 µM 0.617011143630758 0.2595930884144 no 890 0.268613687756106 307 1246798 SGTC_1991 st073000 8.92 µM 0.614872312781047 0.260309973377456 no 891 0.269319524428873 318 4301969 YIL048W NEO1 SGTC_2456 5770359 74.46 µM 0.614200472315372 0.260535368571483 no 892 0.269541430652443 309 3118787 SGTC_2285 7945142 200 µM 0.613912092819497 0.260632147580173 no 893 0.269636709345902 307 2970608 SGTC_3169 9102970 49.47 µM 0.612464408943851 0.261118263973012 no 894 0.270115269409598 307 17027839 SGTC_1641 st009299 47.1 µM 0.612391855645181 0.261142638833574 no 895 0.270139264489467 286 4046054 SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM 0.610093115547961 0.261915523969731 no 896 0.270900063422494 314 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_1115 galangin 695.678 nM 0.609947212483424 0.261964619229746 no 897 0.270948388064917 314 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_2939 9044578 71.43 µM 0.60975988655203 0.262027659883269 no 898 0.271010438705687 313 2653634 SGTC_3002 9075603 71.4286 µM 0.609189988127392 0.262219495173449 no 899 0.27119925786939 303 20105405 SGTC_1314 1222-0010 41.1 µM 0.608815734761681 0.262345512898654 no 900 0.271323291437182 305 3526027 SGTC_549 1661-1316 519 µM 0.607668501592694 0.2627319997551 no 901 0.271703678978082 313 2857282 SGTC_2471 5466956 24.79 µM 0.606701259949386 0.263058076126417 no 902 0.272024592940184 288 724419 SGTC_550 4123-0385 25.7 µM 0.606331138318734 0.263182906169603 no 903 0.272147442706453 296 5731123 SGTC_1106 tegaserod maleate 11.7 µM 0.60629325468391 0.263195684800127 no 904 0.272160018495319 301 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation. SGTC_1759 st043059 70 µM 0.604313826348009 0.263863811729984 no 905 0.272817507826799 322 669426 SGTC_2552 juarezic acid 87.02 µM 0.604270390350529 0.263878482601758 no 906 0.272831944410548 293 1549512 SGTC_32 0928-0142 34.1 µM 0.603374296157652 0.264181238671274 no 907 0.273129858831681 307 2244242 SGTC_673 1082-0474 110 µM 0.603232638641412 0.264229115536203 no 908 0.273176968875192 315 3098046 SGTC_2057 5236571 38.335 µM 0.602984403111602 0.264313023884751 no 909 0.273259532527058 315 54684039 YBR257W POP4 SGTC_1792 st045773 43.6 µM 0.602634837012843 0.264431206899415 no 910 0.273375819892049 267 2919270 SGTC_2544 sphondin 68.51 µM 0.602572777525961 0.264452191084839 no 911 0.273396467287503 278 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31 SGTC_668 1682-0499 62.6 µM 0.602427840883819 0.264501201838216 no 912 0.273444691192438 307 682214 SGTC_3192 9110362 49.47 µM 0.602344079916227 0.264529527963893 no 913 0.273472562399818 325 16649480 SGTC_494 Boc-Gly-Val-Val-CHO 140 µM 0.601670632173168 0.264757329327414 no 914 0.273696701183298 306 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA. SGTC_1172 0370-0043 85 µM 0.600796071851816 0.265053308111156 no 915 0.273987910393669 297 376585 SGTC_1295 1013-0063 9.78 µM 0.600515384535821 0.265148337166533 no 916 0.27408140550111 306 6826038 SGTC_2004 4023728 41.89 µM 0.598876388971062 0.265703578212962 no 917 0.274627658747533 324 360084 YDR527W RBA50 SGTC_2157 5649910 96.377 µM 0.598322058867952 0.265891501439669 no 918 0.27481253030619 303 2858091 SGTC_3074 9116018 49.47 µM 0.597670035134147 0.266112629912558 no 919 0.275030061613561 342 17027303 SGTC_131 0141-0277 33.849 µM 0.596984135178342 0.266345347693314 no 920 0.275258986378211 326 1547771 SGTC_647 0140-0236 81 µM 0.59674850448411 0.26642531817377 no 921 0.275337651705313 291 990837 SGTC_162 k030-0015 37.8 µM 0.596101728290281 0.266644889355438 no 922 0.275553634838337 329 1809920 YMR134W ERG29 SGTC_872 0588-0139 234 µM 0.595848587364777 0.266730851949501 no 923 0.275638190887836 289 2047100 SGTC_1549 4'-methoxyflavonol 74.6 µM 0.594328663143192 0.267247288182269 no 924 0.276146155572635 306 97141 SGTC_149 3970-0822 46.1 µM 0.594241577518456 0.26727689320545 no 925 0.276175273844943 320 3114250 YBL034C STU1 SGTC_1341 1486-1360 280 µM 0.593703563781545 0.267459829298577 no 926 0.276355199519192 313 3976547 SGTC_1953 st076800 12.1 µM 0.593666764610653 0.267472344104827 no 927 0.276367508211992 300 297591 SGTC_2848 9016370 25.97 µM 0.592230646880438 0.267960975180407 no 928 0.276848074924399 293 7894410 SGTC_2783 7738165 71.43 µM 0.591218938572345 0.268305472974298 no 929 0.27718686744931 307 17201110 SGTC_2135 5326629 150.42 µM 0.587692155203206 0.269508120801906 no 930 0.278369471034934 307 5020077 SGTC_2537 larixol 68.93 µM 0.587343963555361 0.269627001973174 no 931 0.278486360152091 311 6708759 SGTC_3339 9145883 14.936 µM 0.586221369290562 0.270010462000481 no 932 0.278863381600137 299 2030670 SGTC_2867 9039098 71.43 µM 0.585578600808708 0.270230144100027 no 933 0.279079366103048 312 6463460 SGTC_1197 1601-0112 267 µM 0.584777357970829 0.270504113838789 no 934 0.279348715358514 310 7350313 SGTC_1634 st006576 41 µM 0.584247474601229 0.2706853735776 no 935 0.279526912594053 306 3915356 SGTC_3181 9108277 49.47 µM 0.583374694343889 0.270984061857244 no 936 0.279820544678155 332 17097298 SGTC_837 0091-0265 12.5 µM 0.582666293196121 0.27122661613012 no 937 0.280058984159477 321 759367 SGTC_1649 st011737 51.3 µM 0.580931747482457 0.271820975574491 no 938 0.280643227254855 292 1761035 SGTC_771 0250-0039 27.3 µM 0.580019624573364 0.272133783419462 no 939 0.280950691923678 333 3005115 SGTC_1525 8-methoxypsoralen 92.5 µM 0.579071876138253 0.272458998310941 no 940 0.28127033785123 343 4114 Related to psoralen; DNA damaging agent. SGTC_894 0960-0238 55.9 µM 0.578783052683831 0.272558144917846 no 941 0.281367783870586 318 6741907 YDL195W SEC31 SGTC_2592 piperlongumine 83.33 µM 0.578736785276117 0.272574029144376 no 942 0.281383395525122 319 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_2928 9011484 9.79 µM 0.578184691155138 0.272763605970988 no 943 0.281569716635723 306 2994751 SGTC_104 0074-0074 590.992 µM 0.578158560135119 0.272772580402464 no 944 0.281578536825333 307 3943124 SGTC_1210 3013-0140 750 nM 0.575918036619072 0.273542609596679 no 945 0.282335291827877 304 905973 SGTC_3301 9125354 19.7965 µM 0.574614918808004 0.273990962952196 no 946 0.282775880025763 299 41905162 SGTC_1853 st056710 91.2 µM 0.57379146557218 0.274274469086878 no 947 0.283054462333681 329 269167 SGTC_1134 3477-0009 42.5 µM 0.573591861264209 0.274343212518675 no 948 0.283122010258955 342 3973534 SGTC_1555 citronellol 128 µM 0.573018135306508 0.274540850247855 no 949 0.28331620743296 320 8842 A terpine precursor. SGTC_1512 0259-0544 12.2 µM 0.569338028885361 0.27581024509487 no 950 0.284563381887639 305 18476 SGTC_2131 toluylene red 5.2905 µM 0.568042591188954 0.27625777126308 no 951 0.285003023989761 278 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain. SGTC_2533 agelasine 13.65 µM 0.567510462800374 0.276441705273003 no 952 0.285183710069358 323 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase. SGTC_631 k072-0230 41.5 µM 0.567437476936655 0.27646693804517 no 953 0.285208496934664 311 5773147 SGTC_1221 2958-7315 257 µM 0.567310747477484 0.276510753809146 no 954 0.285251538201367 307 4562705 SGTC_1061 3448-9325 110 µM 0.567269155626963 0.276525134622829 no 955 0.285265664762157 322 723482 SGTC_2272 7805186 180 µM 0.565944748971966 0.276983253601887 no 956 0.285715670137793 338 2956062 YPR165W RHO1 SGTC_2221 6807166 181.081 µM 0.565773009060441 0.277042686511061 no 957 0.285774048453854 297 674925 SGTC_1275 0867-0008 21.1 µM 0.563214276393218 0.277928908930335 no 958 0.286644491306019 314 3422836 SGTC_645 0845-0943 5.41 µM 0.563068505920516 0.277979438466644 no 959 0.286694118087282 311 1885106 SGTC_2375 9072683 200 µM 0.562894684722043 0.278039697300361 no 960 0.2867532999134 316 16798029 SGTC_2310 7668677 200 µM 0.562830979986089 0.278061783504471 no 961 0.286774991253133 341 2197143 SGTC_1021 4476-0760 85.3 µM 0.559226338059504 0.279312892412959 no 962 0.288003630135077 310 746768 SGTC_627 1391-0720 175 µM 0.554739951766412 0.280873850012269 no 963 0.289536272558194 360 997839 SGTC_2892 9047358 58.44 µM 0.55441447086653 0.280987259117683 no 964 0.289647612415672 333 6466771 SGTC_2904 7225135 42.03 µM 0.553392723297334 0.281343415954815 no 965 0.289997260292759 351 4446116 SGTC_3098 9119039 49.47 µM 0.55183646064253 0.281886310341598 no 966 0.290530202209949 323 17161528 SGTC_2482 5981709 142.65 µM 0.549872927253333 0.282571998408026 no 967 0.291203267128736 331 877755 SGTC_344 k064-0035 6.43 µM 0.549037768058846 0.282863888298265 no 968 0.29148976560444 334 5088750 SGTC_376 3970-0862 59.1 µM 0.548768050648906 0.282958186023781 no 969 0.291582319306954 330 3135186 SGTC_3140 9094243 49.47 µM 0.5481957654143 0.28315831650144 no 970 0.291778744720519 344 19291112 SGTC_738 1315-0003 72.4 µM 0.547710834138738 0.283327952081918 no 971 0.291945235883296 342 6251474 SGTC_2772 vinpocetine 57.06 µM 0.54229188627208 0.285226881338582 no 972 0.29380872209623 365 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor. SGTC_2557 derrustone 83.84 µM 0.542259091347538 0.285238391904439 no 973 0.293820016460653 340 629853 An antioxidant. SGTC_1563 conessine 56.1 µM 0.541635538526413 0.285457292439418 no 974 0.294034802311231 351 441082 An anti-amoebic, histamine inhibitor. SGTC_2787 5284540 71.43 µM 0.540718242830894 0.285779457805897 no 975 0.294350901201478 338 736958 SGTC_2706 st078239 82.5 µM 0.54069163613911 0.28578880497869 no 976 0.29436007217373 327 15434492 SGTC_772 k072-0172 35.3 µM 0.540542004581125 0.285841374613836 no 977 0.294411650635887 290 5861980 SGTC_2519 cryptotanshinone 88.04 µM 0.540113242261693 0.285992035935878 no 978 0.294559469439309 312 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE) SGTC_2954 9074818 52.69 µM 0.539681659752446 0.286143726339222 no 979 0.294708295097213 340 16648742 SGTC_2214 7179297 48.276 µM 0.538705677368291 0.2864869004841 no 980 0.295044977839624 321 769744 SGTC_1136 pergolide 1.05886 µM 0.53721318158947 0.287012067989497 no 981 0.295560183542493 331 47811 A dopamine receptor agonist. SGTC_3056 9094900 49.47 µM 0.534934512298199 0.28781474632757 no 982 0.296347571146399 314 25236784 SGTC_1233 0325-0408 14.2 µM 0.533142625249975 0.288446695792354 no 983 0.296967427234493 345 12874 SGTC_1464 k208-0027 110 µM 0.532950255258929 0.288514578273094 no 984 0.297034007802702 336 X1464 SGTC_3316 9136639 10.545 µM 0.531879209536803 0.28889266065351 no 985 0.297404828803857 313 4903665 SGTC_935 2996-0153 430 µM 0.529093154786979 0.289877236984531 no 986 0.298370414875939 335 23738523 SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM 0.528935021439356 0.289933167602338 no 987 0.298425263229147 333 4620898 SGTC_2938 9059746 27.26 µM 0.527338955052574 0.29049796780211 no 988 0.29897911352379 335 6471769 SGTC_3146 9095609 49.47 µM 0.526704467109309 0.29072263707838 no 989 0.299199416507537 329 17173999 SGTC_699 0375-0592 111 µM 0.522562831741876 0.292191163713157 no 990 0.300639255709244 305 762578 SGTC_1674 st016616 23.6 µM 0.521686599200815 0.292502296983936 no 991 0.300944278301798 321 625830 SGTC_1783 st039459 87.517 µM 0.521005084702433 0.292744396038385 no 992 0.301181614628311 389 729761 SGTC_2228 7354201 200 µM 0.520217404783395 0.293024324829089 no 993 0.301456027890726 362 753451 SGTC_259 usnic acid 108.925 µM 0.518432983928468 0.293658938209768 no 994 0.302078103243726 357 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_2629 bisabolol 100 µM 0.517791334172553 0.293887290641485 no 995 0.302301932598583 372 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer. SGTC_1448 4255-0083 152 µM 0.516559304002939 0.294325979687284 no 996 0.302731915265012 360 5399660 SGTC_1133 3473-0247 50 µM 0.515186849608487 0.294815025353847 no 997 0.303211228748913 324 711311 SGTC_893 0958-0369 48.9 µM 0.514645628328597 0.295007981270185 no 998 0.303400337132078 357 6819948 SGTC_3353 9151644 39.2805 µM 0.513864942421514 0.295286413424661 no 999 0.303673209754065 352 4909158 SGTC_222 nsc-310342 10.666 µM 0.509584132682881 0.296815312391975 no 1000 0.305171421286439 354 432556 SGTC_2697 mebhydrolin 72.4 µM 0.508602982059056 0.297166241873177 no 1001 0.305515269149459 333 22530 H1 Histamine receptor antagonist. YIL048W NEO1 SGTC_2985 9022375 71.43 µM 0.508398808086208 0.297239292891732 no 1002 0.30558684425488 329 4939335 SGTC_766 1391-0721 126 µM 0.508398765272995 0.29723930821065 no 1003 0.305586859264233 359 1020919 YIL115C NUP159 SGTC_197 4544-0043 41.561 µM 0.50718480711823 0.297673817370917 no 1004 0.306012577059487 319 896523 SGTC_420 mitomycin C 81.9 mM 0.504596778936786 0.29860111036075 no 1005 0.30692103633135 324 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_474 dl-dihydrosphingosine 5 µM 0.504536084463625 0.298622873006618 no 1006 0.306942355795534 303 3058739 A sphingolipid protein kinase C inhibitor. SGTC_2441 5730946 39.09 µM 0.504331416619309 0.298696264145182 no 1007 0.307014251977018 318 1774275 SGTC_2869 9037858 32.47 µM 0.50426800155308 0.298719005599606 no 1008 0.30703653007047 323 27187042 SGTC_2029 5175081 200 µM 0.503146753603378 0.299121229384111 no 1009 0.307430548802496 318 1380876 SGTC_2167 5876490 200 µM 0.501661280592224 0.299654489396655 no 1010 0.307952902545213 352 686534 SGTC_1102 cgs 12066b 26.1 µM 0.501038220641243 0.29987828565441 no 1011 0.308172112158889 332 6438352 A 5-HT1B full agonist. SGTC_1711 st032263 62.8 µM 0.500850359959584 0.299945777980265 no 1012 0.30823822014167 356 3958979 SGTC_3005 9076496 71.4286 µM 0.500752077436772 0.299981090481591 no 1013 0.308272808140011 332 21368410 SGTC_1141 3253-0389 52.6 µM 0.499931350916413 0.300276047520024 no 1014 0.308561708102812 354 5402031 SGTC_1898 st060199 18.6 µM 0.49909393951019 0.300577135902943 no 1015 0.308856603432273 320 688866 SGTC_1356 1502-0781 85.8 µM 0.497472456827103 0.301160521559674 no 1016 0.309427960617725 327 567702 SGTC_2824 7998404 51.95 µM 0.495378115673855 0.30191478876401 no 1017 0.310166619775906 358 837851 SGTC_1156 4092-0367 4.88 µM 0.494481161695059 0.302238081939965 no 1018 0.310483203685268 338 1357585 SGTC_2620 irigenin 100 µM 0.493659245091727 0.302534465380846 no 1019 0.310773426134916 363 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro. SGTC_1791 st048313 56.1 µM 0.492562668026817 0.302930094214797 no 1020 0.31116081579852 336 1204976 SGTC_2727 riluzole 51.77 µM 0.492312177329784 0.303020500045393 no 1021 0.311249336455717 356 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.  SGTC_1393 3470-5649 58.2 µM 0.491194478197803 0.303424041367944 no 1022 0.311644452009928 332 4108395 SGTC_1631 benzylvanillin 81.9 µM 0.49058505166351 0.303644173764148 no 1023 0.311859980581114 319 75506 SGTC_2166 5933061 31.504 µM 0.48766912108839 0.304698429043806 no 1024 0.312892113596435 340 2877375 SGTC_1488 4013-0813 75.9 µM 0.487477594059206 0.304767732609563 no 1025 0.312959958652594 322 2910057 SGTC_3100 9120536 49.47 µM 0.486994211118549 0.304942674641376 no 1026 0.313131216658233 345 16421196 SGTC_2297 7971671 152.32 µM 0.484579373142587 0.305817300446221 no 1027 0.313987374154849 352 909016 SGTC_1251 0490-5699 265 µM 0.484090521830161 0.305994491718643 no 1028 0.314160813799109 340 3883818 SGTC_350 k064-0020 19.8 µM 0.482043699590735 0.306736884962254 no 1029 0.314887451611477 331 2790705 SGTC_3346 9158254 43.5805 µM 0.481290544311164 0.307010258236607 no 1030 0.315155008245947 343 17639500 SGTC_947 3447-0010 211 µM 0.480999777236125 0.307115826880108 no 1031 0.315258328522868 356 748350 SGTC_2419 paclitaxel 166.5 µM 0.480393355883512 0.307336051393436 no 1032 0.315473858909803 360 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_2159 5658611 73.75 µM 0.479888054649807 0.307519606779167 no 1033 0.315653497798875 361 793844 SGTC_1652 st011932 78 µM 0.479107081548571 0.307803397363706 no 1034 0.315931226070677 344 1551076 SGTC_546 peri-Naphthalide 147 µM 0.47896496455531 0.307855052316119 no 1035 0.315981776645918 323 223824 A penicillin ester. SGTC_573 3702-0553 84.7 µM 0.4773570712219 0.308439734852343 no 1036 0.316553938845442 330 1222756 SGTC_313 3474-0040 5.03 µM 0.477321906327019 0.308452527394506 no 1037 0.316566457041287 335 1043375 YIL048W NEO1 SGTC_1392 3455-1037 33.9 µM 0.474932349300094 0.309322362060728 no 1038 0.317417596545819 354 981132 SGTC_2894 9048625 32.47 µM 0.474775275415569 0.309379576833252 no 1039 0.317473578796656 376 4092861 SGTC_941 3237-0776 460 µM 0.474238472841741 0.309575144135396 no 1040 0.317664930564591 359 760008 SGTC_2 0422-0095 29 µM 0.47420500031907 0.309587340593552 no 1041 0.317676863988831 314 6790840 SGTC_1856 st057054 55.7 µM 0.473303445758251 0.309915920899325 no 1042 0.317998352070404 368 1266018 SGTC_2903 5923464 63.88 µM 0.470994874935877 0.310757993929027 no 1043 0.318822197395364 344 2876576 SGTC_2268 7933382 153.85 µM 0.468103903143918 0.311813902334107 no 1044 0.319855144090447 329 935025 YOR257W CDC31 SGTC_3121 9125696 49.47 µM 0.467947205357816 0.311871179492872 no 1045 0.319911172368432 385 1235365 SGTC_983 1491-0821 12.2 µM 0.467451492139126 0.312052405661709 no 1046 0.320088444796293 329 46495113 SGTC_307 1501-1223 22.3 µM 0.467030499637019 0.312206350660358 no 1047 0.320239028546728 355 2830329 SGTC_3335 9143315 29.6265 µM 0.466951767981441 0.312235144231006 no 1048 0.320267193162003 327 4899691 SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM 0.466552935218954 0.312381022102409 no 1049 0.320409883208405 332 4174840 SGTC_907 3448-6986 75.5 µM 0.464332122758985 0.313193848241708 no 1050 0.321204906421264 363 590582 SGTC_2067 5224629 34.075 µM 0.463021803295315 0.313673856777111 no 1051 0.32167436942651 335 2835000 SGTC_1504 k297-0033 30 µM 0.46243451875924 0.313889098847099 no 1052 0.321884875017153 324 4388117 SGTC_2059 5238311 157 µM 0.461929797543377 0.314074131756326 no 1053 0.322065832393518 336 703021 SGTC_967 1306-0166 352 µM 0.461636347875971 0.314181733126575 no 1054 0.322171062116101 361 4437607 SGTC_970 1315-0089 19.5 µM 0.460067580657156 0.314757232409113 no 1055 0.322733856585641 341 6811083 YLR033W RSC58 SGTC_1602 st001878 87.6 µM 0.459218610979402 0.315068863170573 no 1056 0.323038593560114 375 595405 YLR310C CDC25 SGTC_460 trequinsin 123 µM 0.45836173745528 0.315383528719355 no 1057 0.323346288106566 358 5537 A vasodilator. SGTC_1369 1866-0067 208 µM 0.458096573245166 0.31548093084845 no 1058 0.323441530369337 363 3531355 SGTC_429 1112-0049 25.5 µM 0.458041556660359 0.315501141564107 no 1059 0.323461292796448 318 2836170 SGTC_217 ketoconazole 989 nM 0.457678951754593 0.315634360740443 no 1060 0.323591556030948 335 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4 SGTC_1253 0550-0034 176 µM 0.45766903675925 0.315638003795326 no 1061 0.323595118226264 334 5969915 SGTC_1263 0774-1208 64.8 µM 0.456199582842542 0.316178121409253 no 1062 0.324123232685672 382 906585 SGTC_580 1123-0028 41 µM 0.456010228065029 0.316247749883593 no 1063 0.324191311632082 355 1677248 YPR107C YTH1 SGTC_1708 st033234 31.827 µM 0.456009748751285 0.316247926142417 no 1064 0.324191483967777 328 674664 SGTC_3341 9147222 25.867 µM 0.453327404453078 0.317234961910947 no 1065 0.325156501144589 359 1939759 SGTC_2907 7721985 69.9 µM 0.452925544097196 0.317382948755114 no 1066 0.32530117823776 335 3267881 SGTC_380 3970-0968 6 µM 0.451769164416425 0.317808953482306 no 1067 0.325717642976405 354 2891601 SGTC_2152 5568786 200 µM 0.450977252973364 0.318100829089472 no 1068 0.32600297175671 382 5399883 SGTC_134 0269-0018 6.916 µM 0.448349501441319 0.31907015096089 no 1069 0.326950490283008 361 4378915 SGTC_530 4358-1714 28 µM 0.446794147740177 0.319644471947956 no 1070 0.327511848579536 363 1564641 SGTC_366 0181-0206 4.31 µM 0.445969599998158 0.319949115342578 no 1071 0.327809602715833 354 274874 SGTC_3187 9109394 49.47 µM 0.445674358496516 0.320058226954293 no 1072 0.32791624461836 350 17098090 SGTC_2731 amoxapine 43.43 µM 0.441885197608337 0.32145995607291 no 1073 0.329286141315863 376 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine. SGTC_2078 5212016 200 µM 0.437841913203032 0.322958502060817 no 1074 0.330750442728109 383 1899708 SGTC_2487 5918373 44.05 µM 0.437546576452657 0.323068074614997 no 1075 0.330857502743622 383 2876279 SGTC_211 3455-0679 143.504 µM 0.436428661825762 0.323482969860875 no 1076 0.331262873713749 346 748649 SGTC_1173 0443-0020 122 µM 0.435240569402236 0.323924151095445 no 1077 0.331693908935405 371 5331295 SGTC_1324 1418-0026 34.4 µM 0.433859930450034 0.324437142610289 no 1078 0.332195079315025 348 1372513 SGTC_1622 st003707 19.4 µM 0.432721141287607 0.324860523118798 no 1079 0.332608684524007 359 10140899 SGTC_135 0933-0004 26.348 µM 0.432035372991416 0.325115588164552 no 1080 0.332857852128953 367 21230617 YGL099W LSG1 SGTC_1175 0741-0056 27.6 µM 0.429282672072052 0.326140253233967 no 1081 0.333858762738268 368 765927 SGTC_1412 3909-8563 178 µM 0.428689157673667 0.326361355427299 no 1082 0.334074726035089 380 23767530 SGTC_1334 1486-0610 236 µM 0.427445763342837 0.326824755477052 no 1083 0.334527340558362 356 3742339 SGTC_2997 9067075 71.4286 µM 0.427297512043523 0.326880025028384 no 1084 0.334581322361448 399 27209819 SGTC_2009 4012297 12.05 µM 0.427026154393273 0.326981199683621 no 1085 0.334680138955022 348 45595307 SGTC_2769 toremifene 3.73 µM 0.426764058135316 0.327078933339811 no 1086 0.334775593826101 346 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_3258 9138477 49.47 µM 0.424889462117251 0.327778301038294 no 1087 0.335458628476043 377 4970355 SGTC_1431 4049-0260 9.09 µM 0.424887757030352 0.327778937441661 no 1088 0.335459249995773 358 3854841 SGTC_1921 5740136 50 µM 0.421896356639014 0.328896210797524 no 1089 0.336550334740415 386 1774243 SGTC_2386 9075165 157.42 µM 0.421615326279446 0.329001253062695 no 1090 0.33665290881063 368 16452277 SGTC_1441 4106-0040 13 µM 0.421219875682235 0.329149085681414 no 1091 0.336797266031961 361 2904180 SGTC_2016 5121758 140 µM 0.420698837906903 0.329343907770193 no 1092 0.336987504924591 359 2795203 SGTC_1008 4106-0037 6 µM 0.419399603190477 0.329829908513238 no 1093 0.337462057031071 384 2905394 SGTC_296 1222-0039 74.9 µM 0.419169337995724 0.329916073115415 no 1094 0.337546189569744 344 5984176 SGTC_1904 st060225 78 µM 0.418930066621745 0.330005617366603 no 1095 0.337633621320888 361 66595 SGTC_2080 5212524 12.4 µM 0.418285713930616 0.330246806542473 no 1096 0.337869116726186 372 260183 SGTC_2908 7930301 100 µM 0.417922407509071 0.330382827736608 no 1097 0.338001924473577 342 2223178 SGTC_1843 st055809 45.5 µM 0.417580289707843 0.330510936445397 no 1098 0.338127005094143 353 16413835 SGTC_1859 st055998 20 µM 0.41706655251248 0.330703346693641 no 1099 0.338314864507246 364 676301 SGTC_2005 4024620 188 µM 0.416597965864545 0.330878885705206 no 1100 0.338486248725301 376 236743 SGTC_506 n9-isopropylolomoucine 153 µM 0.415021330646947 0.33146978787548 no 1101 0.339063144025973 377 6610355 SGTC_3266 9136860 49.47 µM 0.414928058938396 0.331504758050741 no 1102 0.339097284250661 385 4871271 YPR165W RHO1 SGTC_1570 verbenone 133 µM 0.414828249764998 0.331542180931545 no 1103 0.339133818845733 393 29025 A natural terpanoid with antifungal properties. SGTC_2422 chlorphenesin carbamate 384.24 µM 0.41413446555331 0.33180235782301 no 1104 0.339387816499605 343 2724 A muscle relaxant with antifungal properties. SGTC_2211 7117706 200 µM 0.414115768074115 0.331809370711655 no 1105 0.339394662744921 378 822771 SGTC_3154 9100113 49.47 µM 0.413886970865507 0.331895190760509 no 1106 0.339478443133812 370 25237525 SGTC_690 glyoxal 20.3 µM 0.413116691914186 0.332184181204711 no 1107 0.339760560249252 365 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins. SGTC_1148 3909-7663 27.7 µM 0.412695203837797 0.332342355830422 no 1108 0.339914969614003 374 4084526 SGTC_1075 aripiprazole 15.2 µM 0.412446769681178 0.332435601355687 no 1109 0.340005994405389 349 60795 An atypical antipschotic. YIL048W NEO1 SGTC_27 0485-0001 32.618 µM 0.411090442373586 0.332944858430603 no 1110 0.340503108977711 368 2054479 SGTC_1905 st060207 84.5 µM 0.409547699056293 0.333524483435818 no 1111 0.341068884841801 367 1948547 SGTC_1770 st043884 66.3 µM 0.409386507756424 0.333585067681887 no 1112 0.341128019765125 359 670149 SGTC_1088 bifonazole 369 nM 0.408746630680207 0.33382561024751 no 1113 0.341362804673865 355 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase. SGTC_1927 st060202 13.8 µM 0.408215919182234 0.334025167117933 no 1114 0.341557580937976 359 688887 SGTC_785 1270-0111 65.3 µM 0.40705780198185 0.334460802493427 no 1115 0.341982767642606 351 6741994 SGTC_218 alverine citrate 93.75 µM 0.406386119322948 0.334713563700825 no 1116 0.342229458526257 392 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_3196 9111891 49.47 µM 0.404569739591163 0.335397461325435 no 1117 0.342896902743426 384 18891510 SGTC_1304 1165-0502 251 µM 0.402343559160996 0.336236400140053 no 1118 0.34371560071952 351 767425 SGTC_483 fpl-64176 144 µM 0.402335459202382 0.336239454112101 no 1119 0.343718580894088 396 3423 SGTC_1787 fluconazole 80 µM 0.4007657344657 0.336831499854227 no 1120 0.344296304460686 352 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C SGTC_2179 6298986 200 µM 0.40040521201741 0.336967533600622 no 1121 0.344429043000356 365 738374 SGTC_2703 st077852 53.4 µM 0.400248515274515 0.33702666568118 no 1122 0.344486742184315 372 6281836 SGTC_78 0336-0123 156.75 µM 0.399888294109518 0.337162616302811 no 1123 0.344619397252635 357 6765896 SGTC_50 0929-0078 56.389 µM 0.39958710970197 0.33727630226167 no 1124 0.344730326110452 379 1377751 SGTC_2558 carylophyllene oxide 100 µM 0.395932302299165 0.338657038212395 no 1125 0.346077485209491 385 6708694 An oxygenated terpenoid and antifungal agent. SGTC_109 0132-0036 33.701 µM 0.394314479793605 0.339268923730277 no 1126 0.34667443709681 390 67274 A color developer. SGTC_2496 diffractaic acid 79.83 µM 0.393433908025824 0.33960214795342 no 1127 0.346999514862185 372 94870 An apoptosis inducer which activates caspases. SGTC_2770 toltrazuril 17.5 µM 0.389148713049086 0.34122552907302 no 1128 0.348583070032514 368 68591 Kills coccidiodes. SGTC_753 1322-0200 289 µM 0.388848918862004 0.341339212042345 no 1129 0.348693955475185 362 5403907 SGTC_2168 5727979 200 µM 0.388735032930046 0.341382401747326 no 1130 0.34873608206872 363 695210 SGTC_2270 7924575 90.91 µM 0.388587700384471 0.341438278712001 no 1131 0.348790583386656 382 1262135 SGTC_1497 4476-2978 41.3 µM 0.387936024999236 0.341685473126753 no 1132 0.349031688833674 397 1528379 SGTC_164 4100-3994 89.624 µM 0.387000481432477 0.342040463515496 no 1133 0.349377925769862 409 4615967 SGTC_2836 9010338 19.48 µM 0.38670737528252 0.342151710886575 no 1134 0.349486427738046 354 2994051 SGTC_2457 5731572 11.68 µM 0.385894174041594 0.342460430170968 no 1135 0.349787522761309 402 2865357 SGTC_10 0279-0212 42.575 µM 0.385067143136266 0.342774507662775 no 1136 0.350093835266063 370 39851 YBR002C RER2 SGTC_1941 st076221 61.8 µM 0.385030095824717 0.342788579484864 no 1137 0.350107558990329 350 2828568 SGTC_1377 2944-0135 198 µM 0.383057269349227 0.343538240354674 no 1138 0.350838650843551 356 1894137 SGTC_428 3448-4153 16.5 µM 0.38300724799483 0.343557256152379 no 1139 0.350857194997962 359 3834874 SGTC_1675 st018485 24.5 µM 0.382605454627969 0.343710013704437 no 1140 0.351006162630854 356 3323024 SGTC_2484 5809818 12.04 µM 0.380993588342869 0.344323084424609 no 1141 0.351604003077639 361 2870548 SGTC_2370 9071495 200 µM 0.380894741351545 0.344360694052327 no 1142 0.351640677345116 398 21791103 SGTC_819 1013-0258 27.7 µM 0.380221601922457 0.344616853261956 no 1143 0.351890462626237 376 5753198 SGTC_1960 st011366 51.8 µM 0.379507047747518 0.344888850586061 no 1144 0.352155685846654 377 3972846 SGTC_529 4076-0302 30.3 µM 0.379148811955744 0.345025244366435 no 1145 0.352288680380553 384 5816522 SGTC_2062 5245942 200 µM 0.378329245145474 0.345337359851676 no 1146 0.352593011323519 385 1376160 SGTC_1716 st033144 30.6155 µM 0.377089930755038 0.345809527514492 no 1147 0.353053386952161 416 674617 SGTC_2710 st078562 53.7235 µM 0.37641708486606 0.346065976294932 no 1148 0.353303423265355 401 17250908 SGTC_2699 st077704 54.6 µM 0.374534205442156 0.346783992767575 no 1149 0.354003456528308 366 645852 SGTC_1850 st056238 17 µM 0.374337732008547 0.346858947636731 no 1150 0.354076531618287 400 5393177 SGTC_3168 9103419 49.47 µM 0.37316518446733 0.347306400573537 no 1151 0.35451275322549 402 16649256 SGTC_3048 9093155 49.47 µM 0.370108994312927 0.348473664986574 no 1152 0.355650640370194 385 25236002 SGTC_1227 3909-8010 46.6 µM 0.369878337999601 0.348561819014247 no 1153 0.355736571193284 385 15982272 SGTC_2618 avocadyne 43.43 µM 0.368785438422552 0.348979623007108 no 1154 0.356143829647961 402 3015189 SGTC_293 4049-0273 38.5 µM 0.36762512592884 0.349423398699852 no 1155 0.356576388543754 370 1380311 SGTC_356 1634-0012 32.5 µM 0.367344099339053 0.349530911750134 no 1156 0.35668118168086 420 735457 SGTC_1532 4',5'-dihydroxyflavone 78.7 µM 0.367291059958996 0.349551204513739 no 1157 0.356700960962779 377 165521 SGTC_2224 6650123 117.647 µM 0.365993366120068 0.350047833469765 no 1158 0.357185012870303 411 2908370 SGTC_3286 9117135 37.221 µM 0.365436847192871 0.350260892582112 no 1159 0.357392670116831 395 3438150 SGTC_3064 1327-0027 10 µM 0.363346367741048 0.35106163758658 no 1160 0.358173080105841 409 16000455 YPR107C YTH1 SGTC_2198 6589944 200 µM 0.363203324021953 0.351116453814259 no 1161 0.358226502363579 369 5290268 SGTC_3175 9106517 49.47 µM 0.362798879903012 0.351271458860239 no 1162 0.358377564331973 404 41468073 SGTC_34 0469-0683 81.75 µM 0.362556578408496 0.351364333862516 no 1163 0.35846807581192 381 3690923 SGTC_465 cgp-37157 41 µM 0.358275616863166 0.353006700418225 no 1164 0.360068531774318 390 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange. SGTC_2412 st077135 33.4 µM 0.358235568352557 0.353022077795603 no 1165 0.360083515721144 407 13258915 SGTC_1967 st070177 51.4 µM 0.357872389648101 0.353161538032221 no 1166 0.360219407000287 419 5729214 SGTC_290 2043-6722 48.1 µM 0.357179832042566 0.353427534070641 no 1167 0.360478591563938 395 773758 YLR208W SEC13 SGTC_3311 9131146 2.8755 µM 0.357161113653583 0.353434724383672 no 1168 0.360485597673074 387 4900406 YPR165W RHO1 SGTC_608 k048-0125 159 µM 0.356094251373333 0.353844625611126 no 1169 0.360884991092412 398 6817652 YLR060W | YFL022C FRS1 | FRS2 SGTC_84 0443-0269 128.823 µM 0.355944642903256 0.353902120532122 no 1170 0.360941011061874 414 6150058 SGTC_1629 st005085 44.9 µM 0.35488324086086 0.354310115675297 no 1171 0.361338532110568 414 24207091 SGTC_113 0099-0221 2.5 µM 0.353754614931104 0.354744134682274 no 1172 0.361761394433968 418 89219 SGTC_976 1348-1067 47.6 µM 0.352903328479225 0.355071626165866 no 1173 0.36208045770898 384 5310671 YGL099W LSG1 SGTC_1164 k060-0068 93.7 µM 0.352768648656754 0.355123447562106 no 1174 0.362130944670987 377 5963676 SGTC_2271 7849410 118.62 µM 0.351994640332384 0.355421318355757 no 1175 0.362421140991659 419 972430 SGTC_3166 9102297 49.47 µM 0.351525764891337 0.355601804224493 no 1176 0.362596973342274 394 25237072 SGTC_2490 carminic acid 95.39 µM 0.351387826465692 0.355654907512844 no 1177 0.362648706965419 390 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_515 4092-1064 102 µM 0.350380442542274 0.356042813259143 no 1178 0.36302660094028 417 717353 SGTC_358 0075-0058 9.45 µM 0.349662570966848 0.356319329647211 no 1179 0.363295973286476 425 1069125 SGTC_1527 coumarin 137 µM 0.349587661141542 0.356348188460292 no 1180 0.363324086161761 437 323 A hepatotoxic, DNA x-linker. SGTC_818 4072-2707 53.5 µM 0.347273221940345 0.357240224705799 no 1181 0.364193033111459 389 882871 SGTC_2984 9022109 38.96 µM 0.346081737874896 0.357699753877577 no 1182 0.364640643730315 411 6459207 SGTC_120 rhodamine 6G 52.259 µM 0.344629150805163 0.358260263809571 no 1183 0.365186593857579 411 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase SGTC_1122 capsaicin 818.572 nM 0.344305068553143 0.35838535920033 no 1184 0.365308436453695 417 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_2525 harmine 47.85 µM 0.34402115487465 0.358494962057382 no 1185 0.365415188367845 430 5280953 A monoamine oxidase inhibitor SGTC_152 4469-0003 551.229 µM 0.342370002053417 0.359132608641281 no 1186 0.366036230401388 390 697280 SGTC_367 0335-0881 7.1 µM 0.34183174025117 0.359340560959802 no 1187 0.366238760804923 414 23828853 SGTC_1476 4112-3294 3.34 µM 0.341737415028289 0.359377006903718 no 1188 0.366274256156502 413 704369 SGTC_2853 9015042 58.44 µM 0.341221276909734 0.359576458084474 no 1189 0.36646850339762 366 6457456 SGTC_2801 7907800 81.82 µM 0.338728292234578 0.360540359594706 no 1190 0.367407212604161 419 6620925 SGTC_1994 st072947 40.9 µM 0.338365185088033 0.360680827505575 no 1191 0.367544003366352 416 5286565 YDL195W SEC31 SGTC_2316 5844804 197.44 µM 0.336961640218608 0.361223965118328 no 1192 0.368072908703421 399 776813 SGTC_885 0865-0106 16.8 µM 0.336070790518333 0.36156884747928 no 1193 0.368408742230664 385 2793380 SGTC_108 0509-0257 621.132 µM 0.335929448304841 0.361623576862047 no 1194 0.368462034827311 386 536624 SGTC_2308 7584454 197.62 µM 0.335845417710365 0.361656115847567 no 1195 0.368493719474102 410 893577 SGTC_3345 9148410 3.559 µM 0.333948605228967 0.362390880196633 no 1196 0.369209170711235 410 4903596 SGTC_3319 9138450 16.7555 µM 0.333470779808246 0.362576054532522 no 1197 0.369389471375796 407 2029690 SGTC_2786 7743617 45.45 µM 0.332828398710821 0.362825050701493 no 1198 0.369631910068389 383 583674 SGTC_289 k017-0060 526 µM 0.332792105905057 0.36283912004819 no 1199 0.369645608750995 428 5512909 SGTC_215 1287-0124 461.5 µM 0.332702096754673 0.362874013986911 no 1200 0.369679583327188 411 5560863 SGTC_1818 st052136 56.3 µM 0.330051342720861 0.363902143879719 no 1201 0.370680583909003 406 674169 SGTC_3014 9081533 49.47 µM 0.329380455437524 0.364162512140472 no 1202 0.37093406932804 425 21367265 SGTC_3294 9122953 26.2835 µM 0.328333887618727 0.364568805461587 no 1203 0.371329612228032 413 16459826 SGTC_4 0960-0234 25.671 µM 0.328145630819749 0.364641905736333 no 1204 0.371400776989912 370 6821112 SGTC_1484 3473-2379 286 µM 0.328105912657359 0.364657328961324 no 1205 0.371415791795893 421 671917 SGTC_311 1315-0136 58 µM 0.327967278908819 0.36471116447503 no 1206 0.371468201565408 404 6759207 SGTC_1143 3454-2408 5.08 µM 0.327059438709041 0.3650637711039 no 1207 0.371811464699458 398 X1143 SGTC_1959 st077091 55.8 µM 0.326233265360493 0.365384757395238 no 1208 0.372123937409755 392 821356 YKL052C ASK1 SGTC_2313 7726885 200 µM 0.325979189231438 0.365483490462684 no 1209 0.372220050235682 373 726423 SGTC_1396 3511-0007 98.6 µM 0.324592111269417 0.366022660970927 no 1210 0.372744899258588 416 X1396 SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM 0.323910026664896 0.366287890945871 no 1211 0.373003076356456 433 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair. SGTC_829 1635-0120 117 µM 0.322542878474072 0.36681970153293 no 1212 0.373520729786281 391 285054 SGTC_393 acivicin 6.25 µM 0.320687277229963 0.367541925708533 no 1213 0.374223694890609 400 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1 SGTC_2991 9074669 71.4286 µM 0.315196418380508 0.369681776418087 no 1214 0.37630626239671 432 17333109 SGTC_2202 7226349 200 µM 0.314851337968456 0.369816393900934 no 1215 0.37643726522444 383 844334 SGTC_288 1315-0019 35.1 µM 0.313842870590238 0.370209893134514 no 1216 0.376820191082235 409 6811474 SGTC_1014 4130-3005 69.3 µM 0.312353810774367 0.370791165624295 no 1217 0.377385824559467 400 743608 SGTC_2428 5615643 7.78 µM 0.312032883244957 0.370916482251075 no 1218 0.377507766429072 433 2253075 SGTC_1359 1582-0056 520 nM 0.311875784947009 0.370977831400717 no 1219 0.377567463050338 417 3661189 SGTC_898 1000-0849 28.3 µM 0.310797942004624 0.371398832968424 no 1220 0.377977117151999 431 6751807 SGTC_1736 st036774 51 µM 0.310750607277413 0.371417325273671 no 1221 0.377995110737952 418 1272247 SGTC_2217 6934799 96.0675 µM 0.310188515324507 0.3716369409768 no 1222 0.378208801778149 403 675606 SGTC_3077 9117319 49.47 µM 0.309820285931324 0.3717808350362 no 1223 0.378348812106313 407 17154678 SGTC_635 k038-0028 24.7 µM 0.309471922141374 0.37191698264779 no 1224 0.378481283723759 424 4035102 SGTC_1998 st075797 76.8 µM 0.308877200423812 0.372149448923935 no 1225 0.378707470385065 432 24208315 SGTC_1325 1431-0015 227 µM 0.308532290697425 0.372284289436595 no 1226 0.378838666710989 384 1103340 SGTC_3211 9128781 49.47 µM 0.308412858141825 0.37233098457172 no 1227 0.3788840995707 416 17194361 SGTC_916 4466-0038 42 nM 0.308077007429871 0.372462303839289 no 1228 0.379011868161688 427 5722064 YGL116W CDC20 SGTC_129 0088-0017 176.636 µM 0.307878359036068 0.372539983311238 no 1229 0.379087446728506 426 182446 SGTC_1109 tnp00067 928.257 nM 0.307350671260662 0.372746355522222 no 1230 0.379288235383194 393 676295 SGTC_2725 haloperidol 53.21 µM 0.307311485856801 0.372761681910459 no 1231 0.379303146985643 418 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_1579 chlormadinone acetate 49.4 µM 0.306689466975631 0.373004995961788 no 1232 0.379539873908786 440 45114258 A steroidal progestin. SGTC_996 3970-0799 1.8 µM 0.306495145698961 0.373081018670644 no 1233 0.379613837643292 412 6615648 YGL040C HEM2 SGTC_411 enrofloxacin 100 µM 0.304448794008383 0.373881895470041 no 1234 0.380392999321309 434 71188 A bacterial gyrase inhibitor. SGTC_1811 st050069 61.5 µM 0.303884754783592 0.374102738359002 no 1235 0.380607846405343 438 3877702 SGTC_1871 st057448 67.3 µM 0.303692897575605 0.374177867202862 no 1236 0.380680934758526 437 691747 SGTC_1752 st044819 83.042 µM 0.301749119515531 0.374939294999094 no 1237 0.381421660273222 390 441209 YML126C ERG13 SGTC_67 0335-0847 266 µM 0.301455759592524 0.375054254047005 no 1238 0.381533490256228 430 4552207 YOR254C SEC63 SGTC_1272 0839-0021 27 µM 0.301203504580828 0.375153114176935 no 1239 0.38162965879052 430 5027250 SGTC_2374 9071832 200 µM 0.300914545776905 0.375266368803731 no 1240 0.381739829087862 409 17381698 SGTC_1851 st056236 18.9 µM 0.299735623986379 0.375728547207009 no 1241 0.38218941159882 412 5393171 SGTC_1915 st067105 30.6 µM 0.299215289137329 0.375932593365544 no 1242 0.382387892171915 429 69751 YOR207C | YOR116C RET1 | RPO31 SGTC_175 3793-3120 23.7 µM 0.299125001883297 0.375968002499067 no 1243 0.382422335192368 429 5322297 SGTC_2068 5226020 147 µM 0.298154743277263 0.376348587365197 no 1244 0.382792530670146 406 1810509 SGTC_3122 9126309 49.47 µM 0.29755097520063 0.376585476693203 no 1245 0.383022948297887 462 17591206 SGTC_282 k297-0036 65.7 µM 0.296258210017916 0.377092851303215 no 1246 0.383516448856324 413 5061378 SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM 0.296094857428433 0.377156977804879 no 1247 0.383578820589983 437 368090 SGTC_1059 3448-6867 171 µM 0.295148310611625 0.377528625553361 no 1248 0.383940293031418 419 3934407 SGTC_1545 lovastatin 49.4 µM 0.294889572392778 0.377630235081657 no 1249 0.384039118978133 398 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12 SGTC_719 2810-4230 27.3 µM 0.293763763619094 0.37807245188232 no 1250 0.384469213193889 420 721079 SGTC_2151 5563267 85.4165 µM 0.293540541703863 0.378160152276117 no 1251 0.384554507873828 438 5310824 SGTC_746 1095-0025 46.6 µM 0.293492118905766 0.378179177663787 no 1252 0.384573011306903 448 6749286 SGTC_2833 9001315 45.46 µM 0.293431936182726 0.37820282395475 no 1253 0.384596008836569 387 2989378 SGTC_3108 9121785 49.47 µM 0.292907645947492 0.378408841225779 no 1254 0.384796372214598 434 17140271 SGTC_1571 st070080 73.4 µM 0.291522335660202 0.378953358290354 no 1255 0.385325931975153 393 4315245 SGTC_3270 9137563 49.47 µM 0.291337665344326 0.379025963914557 no 1256 0.385396541701491 440 17015724 SGTC_3214 9129694 49.47 µM 0.28975220609711 0.379649483973916 no 1257 0.386002906984239 448 17158655 SGTC_1039 k821-0043 94 µM 0.28969230648658 0.379673047086959 no 1258 0.386025821302732 421 15992768 SGTC_644 1498-1197 63.3 µM 0.288998076773201 0.379946173481691 no 1259 0.386291424653477 415 6741615 SGTC_2328 6201408 200 µM 0.288659080778187 0.380079564298414 no 1260 0.386421139529664 410 2890418 SGTC_1437 4092-1038 11.6 µM 0.288638923168213 0.38008749652323 no 1261 0.386428853123665 434 3977136 SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM 0.288397354728249 0.380182560087894 no 1262 0.386521296188023 393 16623 A steroid. SGTC_2764 methyldopa 94.69 µM 0.287678246397703 0.380465591044127 no 1263 0.38679652163651 432 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent. SGTC_2811 7967822 32.47 µM 0.286704678506419 0.380848875670601 no 1264 0.387169227494573 394 2232244 SGTC_508 roscovitine 141 µM 0.286212175832879 0.381042813965088 no 1265 0.387357809344804 440 160355 A CDKinase inhibitor. SGTC_1996 st072960 66.8 µM 0.283732158195195 0.382019851499891 no 1266 0.388307824193286 423 1719405 SGTC_2641 levomentholum 100 µM 0.283652655852694 0.382051185026901 no 1267 0.388338290070038 437 16666 SGTC_1740 st038286 13.222 µM 0.283629863563196 0.382060168084824 no 1268 0.388347024368121 382 716786 SGTC_2251 lansoprazole 556 µM 0.283057468978132 0.382285785083949 no 1269 0.38856639182855 422 3883 Gastric proton pump inhibitor. YBR192W RIM2 SGTC_681 1642-0006 26.6 µM 0.281748690299668 0.382801807816563 no 1270 0.389068108382286 448 4446530 SGTC_1236 0330-0013 258 µM 0.281198518198611 0.383018790792618 no 1271 0.389279070567523 411 4617066 SGTC_2704 st078022 71.1 µM 0.280260344947926 0.383388882610881 no 1272 0.389638886125177 431 54697681 SGTC_3218 9131285 49.47 µM 0.280243279102272 0.383395615754777 no 1273 0.389645432229178 434 17156417 SGTC_1213 1315-0166 115 µM 0.277540339261221 0.38446247453304 no 1274 0.390682617813701 391 768401 SGTC_3130 9127414 49.47 µM 0.277226737363026 0.384586311028389 no 1275 0.390803005227484 406 1494646 SGTC_509 pifithrin 175 µM 0.277077683843432 0.384645174067184 no 1276 0.39086022847411 431 4817 A p53 inhibitor. SGTC_469 w7 172 µM 0.276419058867327 0.384905304862428 no 1277 0.391113109951926 430 45115570 A P450 inhibitor. SGTC_3036 9090181 49.47 µM 0.275507269588839 0.385265511032109 no 1278 0.391463270763245 420 25236586 SGTC_255 tunicamycin 200.472 nM 0.273889999203625 0.38590466384479 no 1279 0.392084578653063 425 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_2002 4023503 131 µM 0.273676110232008 0.385989217002013 no 1280 0.392166769170903 446 4736863 YCR052W RSC6 SGTC_425 3825-7017 13.1 µM 0.27320304451289 0.386176245408532 no 1281 0.392348569897211 463 3397440 SGTC_3326 9140064 16.379 µM 0.272878838077931 0.386304436986869 no 1282 0.392473177078915 417 1868434 SGTC_2497 7-hydroxyflavone 100 µM 0.271060156457776 0.387023775405435 no 1283 0.393172382633491 438 5281894 SGTC_348 k064-0012 10.7 µM 0.270292956158535 0.387327340714193 no 1284 0.393467441964627 409 5066323 SGTC_2108 5365811 200 µM 0.267561138560564 0.388408822850073 no 1285 0.394518573749895 394 780283 SGTC_2435 5706476 10.6 µM 0.266359588533381 0.388884771583069 no 1286 0.394981142495317 422 5725375 SGTC_1302 1159-0335 255 µM 0.266014055845595 0.389021672241943 no 1287 0.395114191963307 419 649284 SGTC_749 1000-0129 128 µM 0.265968459730754 0.389039738532383 no 1288 0.395131749939035 435 708470 SGTC_1137 ixabepilone 100 µM 0.265367023051938 0.389278064822184 no 1289 0.395363368766663 412 154225 A novel microtubule stabilizer. SGTC_1700 st030840 7.9285 µM 0.265197869998294 0.389345101199419 no 1290 0.395428517836448 427 5499307 SGTC_1290 0986-0249 10.2 µM 0.265126459182399 0.389373402725983 no 1291 0.395456022493036 437 53329 SGTC_1992 st073643 23.3 µM 0.264911049653776 0.389458777360431 no 1292 0.395538992982465 415 3161292 SGTC_2498 4'-Methoxychalcone 54.63 µM 0.263498985919053 0.390018561546479 no 1293 0.396083002530775 397 641818 YHR062C RPP1 SGTC_1099 5-nonyloxytryptamine 2.85 µM 0.263058406197271 0.39019326724546 no 1294 0.396252781096356 417 23581825 A 5-HT1D beta serotonin receptor agonist. SGTC_1353 1498-1206 8.11 µM 0.261624993826581 0.390761820076903 no 1295 0.396805286358245 434 6756808 SGTC_610 4215-0184 155 µM 0.260635565467971 0.391154406160354 no 1296 0.397186780035852 440 5605015 SGTC_1587 estradiol valerate 56.1 µM 0.260281679302223 0.391294848317159 no 1297 0.397323251755443 441 13791 A steroid. SGTC_2291 7917025 104.35 µM 0.259905921703224 0.391443985817057 no 1298 0.397468171676423 421 2964612 SGTC_675 1309-0189 238 µM 0.259315307265321 0.391678431849347 no 1299 0.397695984885065 387 4246530 SGTC_1043 0916-0009 19.3 µM 0.257172210360943 0.392529469912439 no 1300 0.398522917807468 454 3101130 SGTC_1249 0481-0015 10.2 µM 0.257139278118621 0.392542551546778 no 1301 0.398535628570483 446 4227577 SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM 0.256156768441474 0.392932888445014 no 1302 0.398914894461495 428 17037758 SGTC_735 3076-0345 636 µM 0.255911764158139 0.393030241896708 no 1303 0.399009485277136 437 2888990 SGTC_1704 st028805 70.8 µM 0.255398640376532 0.39323415539855 no 1304 0.399207610401248 409 2876101 SGTC_587 k089-0003 57 µM 0.255274583185652 0.393283459668955 no 1305 0.399255514724187 459 9659696 SGTC_1280 0880-0253 10.1 µM 0.255097667630377 0.393353774493968 no 1306 0.399323832774819 444 6836607 SGTC_2142 5622915 118.518 µM 0.255079274698451 0.393361084937145 no 1307 0.399330935601714 423 5322196 SGTC_2250 alverine citrate 130 µM 0.254158707454541 0.393727020996356 no 1308 0.399686474999956 418 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1 SGTC_362 0310-0100 9.03 µM 0.252684536057563 0.394313216469533 no 1309 0.400255999310239 398 790235 SGTC_309 k408-0051 1.48 µM 0.251107004934175 0.394940777531303 no 1310 0.400865690116616 450 3640463 SGTC_3274 9138298 49.47 µM 0.250536854617035 0.395167657425361 no 1311 0.401086103692999 419 17015756 SGTC_260 nsc-65238 3.989 µM 0.250191080340752 0.395305268689639 no 1312 0.40121979140672 419 3246252 SGTC_1419 3993-2473 62.6 µM 0.249609721452362 0.395536667353138 no 1313 0.401444589946561 421 704026 SGTC_2611 pyromycin 23.93 µM 0.248779138036359 0.395867328902845 no 1314 0.40176581464476 402 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release. SGTC_1775 st081588 35.1725 µM 0.248131070550533 0.396125381547606 no 1315 0.402016498177197 424 1426443 YGL099W LSG1 SGTC_2607 solasodine 47.35 µM 0.247263009668116 0.39647110421459 no 1316 0.402352342046985 416 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity. SGTC_478 N-arachidonylglycine 10 µM 0.246621294626446 0.396726732464562 no 1317 0.402600661387761 436 5283389 SGTC_2236 dapsone 200 µM 0.245841720128034 0.397037336966425 no 1318 0.402902379965574 442 2955 A bacterial DFR inhibitor. An anti-cancer agent. SGTC_1710 st031758 61.5 µM 0.244648482695195 0.397512882916109 no 1319 0.403364310376996 446 5394341 SGTC_1056 3448-1962 115 µM 0.243590131423336 0.397934799641072 no 1320 0.403774136048232 433 715507 SGTC_960 1222-0186 7.7 µM 0.241218778888026 0.39888058326626 no 1321 0.404692778558146 437 3126296 SGTC_2123 5259487 200 µM 0.240269401697794 0.399259397049205 no 1322 0.405060707105046 447 2173474 SGTC_1728 st035614 33.7865 µM 0.23787866446308 0.400213751690829 no 1323 0.405987601937124 424 15945546 SGTC_2547 epiafzelechin trimethyl ether 100 µM 0.23770525077526 0.400282999687126 no 1324 0.406054855430089 444 6708630 An antioxidant. SGTC_1617 st002906 78 µM 0.237374287088141 0.400415169650584 no 1325 0.406183217835334 457 5150859 SGTC_1174 0739-0097 51.1 µM 0.236441676345458 0.400787667965601 no 1326 0.406544979872604 446 728447 SGTC_244 nsc-207895 1.295 µM 0.235555491800784 0.401141706592928 no 1327 0.406888806998023 432 42640 SGTC_586 0957-0265 8.15 µM 0.235400228392315 0.401203744075937 no 1328 0.406949054411318 470 6752309 YPR165W | YPR107C RHO1 | YTH1 SGTC_513 4245-1575 41.7 µM 0.234052942481771 0.40174217383942 no 1329 0.407471938871138 431 719745 SGTC_2546 rhodinyl acetate 100 µM 0.233931793991054 0.401790598817764 no 1330 0.407518964946426 439 6708682 SGTC_3248 9135562 49.47 µM 0.233886825466387 0.401808573835975 no 1331 0.407536420667974 404 17650701 SGTC_1499 4480-0877 67.3 µM 0.233384874395751 0.402009230036802 no 1332 0.407731278699075 450 2861909 SGTC_2433 5607874 27.82 µM 0.232518183238556 0.402355752778993 no 1333 0.408067782997541 454 2252428 SGTC_245 methotrexate 289.6 µM 0.231364276490565 0.402817229884085 no 1334 0.408515907760959 452 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2 SGTC_1345 1488-0192 31.4 µM 0.230236457310667 0.403268404771753 no 1335 0.408954016932599 450 658348 SGTC_1092 toremifene 6.32 µM 0.229570335179871 0.403534942048902 no 1336 0.409212830166457 464 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_560 2332-1943 155 µM 0.229132642728317 0.403710101534547 no 1337 0.409382911525442 457 21177716 SGTC_70 0141-0289 43.283 µM 0.228219742320762 0.404075495890069 no 1338 0.409737707117061 422 352408 SGTC_2540 epiandrosterone 100 µM 0.227644239218836 0.404305887808608 no 1339 0.409961412420407 442 441302 A steroid. SGTC_1063 disulfiram 1.84 µM 0.227308011357613 0.404440505718812 no 1340 0.410092121992759 423 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_761 k216-0224 480 µM 0.226769768297513 0.404656029419467 no 1341 0.410301386360345 471 1340404 SGTC_2623 humulene 100 µM 0.226680571067371 0.40469174863923 no 1342 0.41033606796087 411 6187145 An anti-inflammatory. SGTC_775 4577-0580 57.3 µM 0.225026803891197 0.405354146780209 no 1343 0.410979211232029 446 2006902 SGTC_861 0443-0273 110 µM 0.222861702949744 0.406221763662311 no 1344 0.411821571698879 447 6149169 SGTC_2367 9070478 135.38 µM 0.222236778743384 0.406472274245197 no 1345 0.412064782300562 442 572802 SGTC_48 0382-0018 55 µM 0.222049172456319 0.406547486618309 no 1346 0.412137802292349 390 762596 SGTC_163 TUB2.036 7.546 µM 0.221659333007517 0.406703786380312 no 1347 0.412289545063263 456 15992207 YJR013W GPI14 SGTC_2040 5100729 123 µM 0.221489235012134 0.406771989053256 no 1348 0.412355758843262 456 11840 YJR013W | YDR381W GPI14 | YRA1 SGTC_1829 berberine 14.4 µM 0.221302967571547 0.406846678287769 no 1349 0.412428269739406 450 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_964 1287-0107 19.4 µM 0.2208918168027 0.407011552886608 no 1350 0.412588334648225 468 51516812 YPR165W RHO1 SGTC_3135 9127742 49.47 µM 0.220727761672742 0.407077344848305 no 1351 0.412652206931379 448 3643468 SGTC_2256 7954252 200 µM 0.220485417075008 0.40717453847757 no 1352 0.4127465642183 444 2972920 SGTC_794 k038-0031 316 µM 0.217889151286881 0.408216142569963 no 1353 0.413757740050468 435 6624242 SGTC_1815 st051655 58.2 µM 0.216410561400335 0.408809633212929 no 1354 0.41433386725825 445 5984156 SGTC_93 0109-0045 59.227 µM 0.215254785680904 0.409273695316632 no 1355 0.414784339544916 462 88733 SGTC_1391 3442-0225 151 µM 0.214399255393785 0.409617286110292 no 1356 0.415117861137575 435 5227075 SGTC_720 r052-1644 49.9 µM 0.211754312642637 0.410679963510261 no 1357 0.416149356700036 451 1422863 YOR257W CDC31 SGTC_322 k048-0136 19.3 µM 0.211144161061111 0.410925201840685 no 1358 0.416387390691011 438 6823282 SGTC_2207 7258803 200 µM 0.209807451792273 0.411462587203619 no 1359 0.416908978410375 455 3666799 SGTC_1114 scopoletin 1.73284 µM 0.209062372299351 0.41176219707798 no 1360 0.417199774084008 472 5280460 A coumarin with genotoxic properties. SGTC_1601 4'-hydroxyflavanone 55.5 µM 0.208546355098829 0.411969727048847 no 1361 0.417401196026529 452 165506 SGTC_514 4466-0038 2.65 nM 0.208057093450857 0.412166519308426 no 1362 0.417592194238557 441 5722064 SGTC_728 3030-5151 22.5 µM 0.207937106225745 0.412214784297671 no 1363 0.41763903788334 436 3125388 SGTC_1724 st037281 8.293 µM 0.206770403466176 0.412684160842746 no 1364 0.418094585622741 435 574124 YDL195W SEC31 SGTC_942 3253-1115 227 µM 0.204776274654447 0.413486708208793 no 1365 0.418873462142968 454 46497897 SGTC_585 0kpi-0023 191 µM 0.204529809747075 0.413585924448013 no 1366 0.418969749752986 464 64601 SGTC_277 nystatin 15.5 µM 0.203966060391624 0.413812886581119 no 1367 0.419190010617589 463 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM 0.203809845767639 0.413875782756382 no 1368 0.4192510492617 451 6708760 SGTC_1238 0333-0287 48.8 µM 0.202171135866372 0.414535703933697 no 1369 0.419891468713757 431 7226 SGTC_3352 9151559 45.5865 µM 0.202130059154292 0.414552248951861 no 1370 0.419907524517362 431 17159339 SGTC_1551 6-bromo-3'-methylflavone 63.5 µM 0.201842478272109 0.414668086004655 no 1371 0.420019936033294 458 688751 SGTC_1995 st072814 61.1 µM 0.201596185831141 0.414767298048528 no 1372 0.420116213638002 432 5769371 SGTC_1572 epiandrosterone 68.9 µM 0.199393200371663 0.415654950411105 no 1373 0.420977589506703 443 441302 A steroid. SGTC_2583 asiatic acid 100 µM 0.198665157003092 0.415948396940002 no 1374 0.421262340689816 496 5320556 A kinase inhibitor; arrests cells at G2/M. SGTC_168 3970-0862 530.542 µM 0.19806533233463 0.416190198620264 no 1375 0.421496974128402 449 3135186 SGTC_2258 7960471 200 µM 0.198054732998436 0.416194471716553 no 1376 0.421501120522044 478 2974708 SGTC_2864 9034755 47.6 µM 0.196595082686263 0.416783020545524 no 1377 0.422072209482778 442 4930451 SGTC_2851 9015922 71.43 µM 0.196511769246747 0.416816619182533 no 1378 0.422104810865973 482 2996893 SGTC_2164 5685496 200 µM 0.196174462322092 0.416952654498724 no 1379 0.42223680789622 417 759046 SGTC_1366 1683-0113 21.9 µM 0.195634636161634 0.417170386167949 no 1380 0.422448074174785 424 708623 SGTC_3340 9146634 11.102 µM 0.194926656990642 0.417455978604403 no 1381 0.422725182599621 474 4907387 SGTC_396 dithiazanine 1.25 µM 0.194493944299464 0.417630552468608 no 1382 0.42289456847284 455 10578 An antihelmenthic. SGTC_1578 josamycin 24.2 µM 0.194335761206179 0.417694374003412 no 1383 0.422956492983839 429 5282165 A P450 substrate. SGTC_762 1165-0429 115 µM 0.194335714676633 0.417694392776831 no 1384 0.42295651119921 468 5967793 SGTC_308 4092-1169 104 µM 0.19362663735852 0.417980508142638 no 1385 0.423234119650207 458 2268590 YDL196W YDL196W SGTC_2377 9073351 62.6 µM 0.193003967889767 0.418231793423426 no 1386 0.423477930295072 458 7337946 YHR072W ERG7 SGTC_1903 st060211 78.3 µM 0.192395898436142 0.418477218919319 no 1387 0.423716052481008 442 688960 SGTC_2560 caryophyllene 100 µM 0.192182936737505 0.418563180804821 no 1388 0.423799455639966 433 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor. SGTC_708 3448-5400 146 µM 0.192105483188002 0.418594445856873 no 1389 0.423829789972661 475 3462195 SGTC_1945 st075991 56.6 µM 0.192010726172858 0.418632696359276 no 1390 0.423866901743342 402 1084980 SGTC_3227 9130768 49.47 µM 0.190591358860698 0.419205743309835 no 1391 0.424422880362067 478 17720899 SGTC_174 3553-0389 74.3 µM 0.189864094457663 0.419499431231403 no 1392 0.424707814555545 440 738071 SGTC_2586 curcumin 80 µM 0.188380557414062 0.420098660227457 no 1393 0.425289169890038 432 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40 SGTC_80 0159-0065 512.242 µM 0.187190070643191 0.420579654668531 no 1394 0.42575580485918 461 1548079 SGTC_20 0481-0013 4.944 µM 0.186557917588373 0.420835112824384 no 1395 0.426003632137728 467 182045 SGTC_848 0368-0089 85.6 µM 0.186486604206552 0.420863933232613 no 1396 0.426031591446159 491 762535 SGTC_2515 chrysin 20.77 µM 0.186130580917176 0.421007821917843 no 1397 0.426171180414544 439 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor. SGTC_2625 euphol 100 µM 0.184934232426616 0.421491409651222 no 1398 0.426640310240424 491 6708538 A triterpene alcohol. SGTC_2776 terbinafine 19.92 µM 0.184832062582355 0.421532714223546 no 1399 0.426680379407815 443 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_905 2-aminofluorene 215 µM 0.183673609651868 0.422001106466528 no 1400 0.427134756554297 464 1539 An established DNA mutagen. YPR165W RHO1 SGTC_2930 9013230 14.89 µM 0.183293506780458 0.422154815886295 no 1401 0.427283864465971 450 2995857 SGTC_1073 triclabendazole 3.09 µM 0.182856588813828 0.422331515353083 no 1402 0.427455272808979 440 50248 An antihelmetic and likely tubulin inhibitor. SGTC_2431 5490079 200 µM 0.181816475280036 0.422752223533926 no 1403 0.427863377309788 469 5722345 SGTC_1933 st074711 15.9 µM 0.17983087247167 0.423555610303516 no 1404 0.428642672988847 480 17250958 SGTC_69 0096-0274 206.684 µM 0.179756802056973 0.423585585807246 no 1405 0.42867174903693 478 6741392 SGTC_843 0310-0051 143 µM 0.179685143080638 0.423614585848555 no 1406 0.428699878852872 481 2065037 SGTC_541 4513-1321 94 µM 0.179056557603448 0.423868989068214 no 1407 0.428946646333816 440 747515 SGTC_455 paf C-16 10 µM 0.177614848290271 0.424452602177621 no 1408 0.429512731356187 458 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis. SGTC_914 3820-6779 408 µM 0.176159873934285 0.425041753032563 no 1409 0.430084171856735 446 2893481 SGTC_426 0988-0037 14.6 µM 0.175787507451799 0.425192559308213 no 1410 0.430230442207736 485 5383008 SGTC_2580 diallyl disulphide 81.36 µM 0.17502995026759 0.425499399361001 no 1411 0.430528049961751 473 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.  SGTC_605 1315-0399 119 µM 0.1746733604064 0.425643847721802 no 1412 0.430668150624533 454 24020461 SGTC_887 0885-0007 9.62 µM 0.173985910303827 0.425922349969856 no 1413 0.430938267648083 480 5719458 SGTC_2075 5212009 200 µM 0.173860417830476 0.425973193922959 no 1414 0.43098758039551 494 780898 SGTC_714 4296-0578 26.1 µM 0.173691531253604 0.426041621173792 no 1415 0.431053946720085 466 1589775 SGTC_2023 5144124 124 µM 0.172738048445083 0.426427982565393 no 1416 0.431428667493111 478 2830192 SGTC_3060 1327-0027 12.5 µM 0.172329301162603 0.42659363296519 no 1417 0.431589324965732 482 16000455 YPR107C YTH1 SGTC_2562 3',7'-dimethoxyflavone 64.92 µM 0.17143181896693 0.426957395231422 no 1418 0.431942118590378 442 688664 SGTC_1729 st035615 45.989 µM 0.171103781779256 0.427090368877087 no 1419 0.432071081148063 457 17385451 SGTC_607 4491-0986 66.8 µM 0.170375935692604 0.427385439220701 no 1420 0.432357247989414 464 698981 YDR232W HEM1 SGTC_2274 7947094 46.08 µM 0.170161719094453 0.427472290828163 no 1421 0.432441478176393 437 2971028 SGTC_138 0850-0259 40.9225 µM 0.169239285435936 0.427846320841527 no 1422 0.432804215070039 472 6813004 SGTC_2094 5332512 191.667 µM 0.168782516638337 0.4280315562791 no 1423 0.432983855360575 480 755774 SGTC_3050 9093513 49.47 µM 0.168290371294629 0.428231155871272 no 1424 0.433177424213341 472 25236664 SGTC_948 3448-0295 75.3 µM 0.168112819639744 0.428303170079987 no 1425 0.433247262135328 440 678569 SGTC_188 3229-0966 278.469 µM 0.167598326167314 0.428511859956303 no 1426 0.433449644049666 480 5722370 SGTC_447 ml7 120 µM 0.167510205371469 0.428547605697499 no 1427 0.433484309128403 465 4216 Selective myosin light chain kinase inhibitor. SGTC_35 0133-0054 64.071 µM 0.167001265741351 0.428754065864101 no 1428 0.433684526497212 453 99677 SGTC_3 0833-0587 95.581 µM 0.166789136483951 0.428840125527796 no 1429 0.433767983390832 452 5382644 SGTC_2076 5212012 200 µM 0.165762028481908 0.429256865326908 no 1430 0.434172114764093 462 604802 SGTC_112 phenothiazine 287.218 µM 0.165571810206445 0.429334053343488 no 1431 0.434246966621997 493 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.  SGTC_1785 bathophenanthroline 24 µM 0.164803334981178 0.429645917727207 no 1432 0.434549389501287 438 72812 An iron chelator. SGTC_2299 7976368 114.88 µM 0.164443904578669 0.429791797683002 no 1433 0.43469085156167 447 2979718 SGTC_1100 amiodarone 5.07 µM 0.164017684758615 0.429964797498615 no 1434 0.434858610960852 473 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. SGTC_3309 9129340 25.759 µM 0.163971151624815 0.429983685805696 no 1435 0.434876927034134 453 17158987 SGTC_1920 st075728 45.7 µM 0.162791437424718 0.430462598092745 no 1436 0.435341325140151 488 3400306 SGTC_2090 5301565 104.445 µM 0.157681291357704 0.432538266029979 no 1437 0.437353971692656 462 2056344 SGTC_2358 9037157 4 µM 0.156940346940425 0.432839383017682 no 1438 0.437645930788473 482 2388925 SGTC_2819 7996655 46.38 µM 0.156429820944283 0.43304688154286 no 1439 0.437847116397035 495 6456960 SGTC_1205 4161-2785 76 µM 0.155280779097489 0.433513966321663 no 1440 0.43829998393553 440 3498106 SGTC_1189 1431-2119 7.28 µM 0.154486518937175 0.433836886897255 no 1441 0.438613069973412 494 3107275 SGTC_840 0245-0196 390 µM 0.153759921654079 0.434132336615403 no 1442 0.438899517922875 453 3827528 SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM 0.153631464344309 0.434184573888526 no 1443 0.438950163247177 475 616764 SGTC_1537 2',6'-dihydroxyflavanone 78 µM 0.152343401093886 0.43470842928318 no 1444 0.439458047633109 498 5106787 A p450 inhibitor. SGTC_1681 tripelennamine 100 µM 0.151087746557056 0.435219214419424 no 1445 0.439953249184312 445 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist. SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM 0.149572460152337 0.435835758555394 no 1446 0.440550968665803 479 5711223 A potent inhibitor of glutathione S-transferases. SGTC_555 4296-0685 37 µM 0.147913990919135 0.436510740065764 no 1447 0.441205323254048 492 2908540 YHR072W ERG7 SGTC_1170 0310-0127 64.8 µM 0.147744463276081 0.436579746685072 no 1448 0.441272220026715 478 774975 SGTC_1926 methyl fluorone black 53.6 µM 0.147608455434629 0.436635110387067 no 1449 0.441325890866837 478 72721 Reacts with homocysteine. SGTC_835 0312-0010 67.2 µM 0.147557579938302 0.436655820216588 no 1450 0.441345967417346 475 1626196 SGTC_814 3342-0569 96 µM 0.147366071129611 0.436733779042513 no 1451 0.441421542208426 492 4346283 SGTC_1467 k284-1082 293 µM 0.147359727237972 0.436736361536774 no 1452 0.441424045723961 475 3334705 SGTC_2290 7904846 200 µM 0.14643929766963 0.437111081840284 no 1453 0.441787303308557 462 2962154 SGTC_806 3966-4455 5.86 µM 0.145959247301003 0.437306539757928 no 1454 0.441976779878762 467 714982 SGTC_1378 2093-0007 380 nM 0.144458694257288 0.437917605298337 no 1455 0.442569135737668 500 3618014 SGTC_1944 st076371 56.9 µM 0.144219060265138 0.438015204451658 no 1456 0.442663745184824 498 24208455 SGTC_618 k072-0232 33.2 µM 0.142531386844119 0.438702673729785 no 1457 0.443330144663579 489 5872756 YGL099W LSG1 SGTC_1387 3342-1166 1.8 µM 0.141461642406296 0.439138527196843 no 1458 0.443752630097706 467 3418228 SGTC_2804 7954240 19.48 µM 0.141001489542054 0.439326033231613 no 1459 0.443934382807977 472 828705 SGTC_570 0987-0065 62.6 µM 0.140581454091337 0.439497203852477 no 1460 0.444100300105166 496 3104428 SGTC_1078 idebenone 36.1 µM 0.13875749996964 0.440240622777731 no 1461 0.444820889562073 504 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen. SGTC_712 r015-0009 80.6 µM 0.138210562216025 0.440463588363242 no 1462 0.445037003885141 468 6813872 YLR060W FRS1 SGTC_473 2-arachidonoylglycerol 10 µM 0.137258279859483 0.440851842435781 no 1463 0.445413323050807 493 5282280 An endocannabinoid. SGTC_1906 st060206 94.7 µM 0.136859429215537 0.441014474343524 no 1464 0.445570953902281 482 5133468 SGTC_3223 9129970 49.47 µM 0.136381256889625 0.441209462888025 no 1465 0.445759945031831 470 17248386 SGTC_312 4092-0653 6.84 µM 0.135233978774012 0.441677356628257 no 1466 0.446213441335284 474 1148278 SGTC_115 0527-0192 112.043 µM 0.133744356079033 0.442284989912057 no 1467 0.446802364573741 496 4233931 SGTC_105 0111-0055 734.78 µM 0.133496576814853 0.442386074978765 no 1468 0.446900335673601 464 5179370 SGTC_3176 9106582 49.47 µM 0.133246745176459 0.442488001138624 no 1469 0.446999121556493 488 17018027 SGTC_821 1114-0266 29.2 µM 0.132484793790513 0.442798885084585 no 1470 0.447300424899804 483 3123235 SGTC_3086 9117350 49.47 µM 0.131321180251197 0.443273719194498 no 1471 0.4477606187318 494 2679265 SGTC_825 1988-2224 89.6 µM 0.129250782306061 0.444118784533195 no 1472 0.448579607348368 475 1180859 SGTC_2101 5377231 179.231 µM 0.128691758180131 0.444347002715311 no 1473 0.448800778598966 485 2844213 SGTC_776 4476-4378 112 µM 0.127971618125693 0.444641022677061 no 1474 0.449085716893835 490 2892008 SGTC_1093 fluphenazine 7.97 µM 0.127430887729696 0.444861813002696 no 1475 0.449299685319525 505 6602611 An atypical antipsychotic. SGTC_3117 9124945 49.47 µM 0.126906255802727 0.445076046374477 no 1476 0.449507297631945 492 17592065 SGTC_489 paxilline 115 µM 0.126379690890571 0.445291085211577 no 1477 0.449715688783077 481 105008 A toxic potassium channel blocker. SGTC_39 0986-0283 58.349 µM 0.12605579874759 0.445423364444291 no 1478 0.449843877889974 468 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2 SGTC_799 1310-0557 151 µM 0.125452645859265 0.445669711397487 no 1479 0.450082605954879 502 5354492 SGTC_881 0833-0569 170 µM 0.124700517615549 0.445976934034781 no 1480 0.450380323801395 448 5418700 SGTC_3242 9133940 49.47 µM 0.124567129092225 0.446031422780922 no 1481 0.450433126419184 479 17248444 SGTC_2897 9048598 12.99 µM 0.124052756094299 0.446241551889225 no 1482 0.450636752149646 480 6467404 SGTC_1278 0874-0585 172 µM 0.123398488342242 0.446508851917301 no 1483 0.450895777027072 472 766306 SGTC_3337 9144342 33.5465 µM 0.123084925173022 0.446636966264725 no 1484 0.451019924237223 491 17682949 SGTC_2432 5630864 12.22 µM 0.122850736946156 0.446732653559449 no 1485 0.451112648122468 477 5714970 SGTC_375 3970-0961 9.27 µM 0.117762293978114 0.44881250396706 no 1486 0.453128003323543 476 2898222 SGTC_2106 5357045 167.29 µM 0.115981768701419 0.44954061130091 no 1487 0.453833495371458 480 668842 SGTC_2854 9024559 71.43 µM 0.115141214644605 0.449884396911808 no 1488 0.454166596280562 481 3163529 SGTC_1485 3909-9022 254 µM 0.114256784580568 0.450246168364811 no 1489 0.454517119498457 505 714516 SGTC_715 0868-0130 184 µM 0.113986460936491 0.450356751089652 no 1490 0.454624263047406 475 2876258 SGTC_2267 7931562 200 µM 0.113644735758735 0.450496547932674 no 1491 0.454759711522039 457 934880 SGTC_3232 9132874 49.47 µM 0.113576713412563 0.450524376025346 no 1492 0.454786673941904 505 3784940 SGTC_657 3534-0529 86.7 µM 0.113285910150185 0.450643347025855 no 1493 0.45490194369911 488 1049549 SGTC_3007 9078383 71.4286 µM 0.113059333231613 0.450736045355645 no 1494 0.454991757794491 472 6496995 SGTC_2862 9027634 71.43 µM 0.111589273338048 0.451337548976129 no 1495 0.455574538767475 496 5012562 SGTC_2036 5160441 105 µM 0.111147136012139 0.451518479991631 no 1496 0.455749835569023 482 134534 YIL048W NEO1 SGTC_1003 4049-0218 100 µM 0.109582424755433 0.452158870281397 no 1497 0.456370274858829 503 295161 SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM 0.107962360796297 0.452822045958346 no 1498 0.457012774687694 504 6708514 SGTC_318 1488-0629 67.2 µM 0.107926954374933 0.452836541107873 no 1499 0.457026817752142 488 3662576 SGTC_3246 9135460 32.98 µM 0.107707609343727 0.452926340880645 no 1500 0.457113816624458 507 41446951 SGTC_3349 9149703 23.001 µM 0.106984565285741 0.453222371867905 no 1501 0.457400612294771 492 4910494 SGTC_963 1269-2853 151 µM 0.10664561205479 0.453361156132919 no 1502 0.457535065855569 466 3668223 SGTC_1621 st003705 32.4 µM 0.106635544461127 0.453365278392316 no 1503 0.457539059471535 476 24207032 SGTC_2664 lyso-paf C-16 73.48 µM 0.106239395609029 0.453527488797086 no 1504 0.457696207312204 484 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_3009 9080819 71.4286 µM 0.104681546696676 0.454165453516478 no 1505 0.458314252551583 485 17027216 SGTC_1494 4358-1428 177 µM 0.104615549791944 0.454192482955948 no 1506 0.458340437732849 507 1564571 SGTC_1449 4112-4002 201 µM 0.103855208756564 0.45450390058705 no 1507 0.458642126525823 476 2059539 SGTC_12 0849-0099 9.267 µM 0.102979020269441 0.454862801255694 no 1508 0.458989810908216 511 6071388 SGTC_2636 apigenin dimethyl ether 100 µM 0.10286679387276 0.454908773631867 no 1509 0.459034346252782 493 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_266 formosanin C 406 nM 0.102763209865788 0.454951206278954 no 1510 0.459075452452264 497 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1 SGTC_658 3253-0951 102 µM 0.0999572516245951 0.456100846372576 no 1511 0.460189131835753 498 1184878 SGTC_2619 obliquin 87.91 µM 0.0997735003616237 0.456176144748736 no 1512 0.460262073348891 502 6708593 A bioactive alkalod. YER133W GLC7 SGTC_1935 st074532 41.6 µM 0.0996522603325503 0.45622582786688 no 1513 0.460310201267102 512 2829742 SGTC_49 0717-0965 32.132 µM 0.0990503769889438 0.456472484587058 no 1514 0.46054913583853 507 5889349 YGL099W LSG1 SGTC_156 3474-0145 5.642 µM 0.097716408341966 0.457019215503458 no 1515 0.461078742970147 500 2265471 SGTC_1842 st055362 61.2 µM 0.09714725473892 0.457252509580687 no 1516 0.461304727223825 477 676032 SGTC_351 caspofungin 25 nM 0.0938079231547404 0.458621584128569 no 1517 0.462630868837717 495 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1 SGTC_548 1436-0017 110 µM 0.0934305356092919 0.458776338393865 no 1518 0.462780766350478 499 9677137 SGTC_3330 9141424 71.43 µM 0.0918286447598114 0.459433290601455 no 1519 0.463417092491152 482 27261020 SGTC_2454 5-benzylidenerhodanine 10.36 µM 0.0914352030200618 0.459594662193461 no 1520 0.463573395463785 517 1273210 SGTC_303 1348-1668 34.2 µM 0.0910010497447042 0.459772739497813 no 1521 0.463745878471651 495 5380509 SGTC_2486 5283202 22.39 µM 0.088675539077186 0.46072673422961 no 1522 0.464669886462359 497 1377751 SGTC_1794 st048918 76.9 µM 0.0881457750211833 0.460944091265674 no 1523 0.464880407368152 508 672303 SGTC_846 0335-0850 148 µM 0.0874860237834201 0.461214797084472 no 1524 0.465142597119706 496 6819598 SGTC_1594 piperine 70.1 µM 0.0871469701485021 0.461353922870783 no 1525 0.46527734529748 508 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_1167 k781-0610 148 µM 0.0857602269825025 0.461923002050999 no 1526 0.465828512108561 498 4525169 SGTC_2917 7979103 53.79 µM 0.0854403735409213 0.462054271734959 no 1527 0.465955648524684 515 2980565 SGTC_2966 9084041 48.03 µM 0.0852639318119452 0.46212668620075 no 1528 0.466025782661241 468 17741380 SGTC_3016 9080866 49.47 µM 0.0844375194258035 0.462465875537457 no 1529 0.466354288798849 517 17066299 SGTC_730 1436-0052 41.2 µM 0.0840681590810327 0.462617483135022 no 1530 0.466501120186009 485 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2 SGTC_946 3434-1334 87.4 µM 0.0835808517486963 0.462817511542547 no 1531 0.466694845874134 496 4047976 SGTC_1055 3448-0672 86 µM 0.083506811231472 0.462847904289274 no 1532 0.466724280865646 494 748378 SGTC_2493 resveratrol 26.09 µM 0.083357934959126 0.462909016874675 no 1533 0.466783467548185 509 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase. SGTC_2767 sibutramine 71.45 µM 0.0832105168280502 0.462969531766721 no 1534 0.466842075261408 509 64765 A serotonin-norepinephrine reuptake inhibitor.  SGTC_2793 7325131 81.82 µM 0.0815769733901721 0.4636401556181 no 1535 0.467491556412042 493 4176441 SGTC_1874 staurosporine 7.6 µM 0.0803190129204699 0.464156660709064 no 1536 0.467991768470852 521 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1 SGTC_1162 k048-0130 20.1 µM 0.0796699330740654 0.464423189622268 no 1537 0.468249886673689 496 6797406 SGTC_3343 9148379 18.9835 µM 0.0794312697407371 0.4645211949585 no 1538 0.468344798776244 509 1955036 SGTC_2156 5649887 115 µM 0.0785350690791126 0.464889232314438 no 1539 0.468701217633163 507 54680440 YKL052C | YBR257W ASK1 | POP4 SGTC_310 1273-0058 1.06 µM 0.0777127127370238 0.465226970902107 no 1540 0.469028290694444 502 2734232 SGTC_106 0092-0003 11.579 µM 0.07720090139275 0.465437182515737 no 1541 0.469231862290502 512 1072148 SGTC_2323 6148992 148.28 µM 0.076956101080671 0.465537730532567 no 1542 0.469329233808231 492 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42 SGTC_160 3453-0671 289.699 µM 0.0766486929846037 0.465663996862811 no 1543 0.469451510730453 501 5322268 SGTC_1911 st060208 74.3 µM 0.0740397047382548 0.466735763562816 no 1544 0.470489396065809 492 688783 SGTC_943 3253-1379 105 µM 0.07386736371918 0.466806569458169 no 1545 0.47055796242927 517 668464 SGTC_283 0987-0079 11.7 µM 0.0725235924316349 0.467358690530902 no 1546 0.471092615428342 517 411556 SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM 0.0722378264004017 0.467476112580134 no 1547 0.471206321338907 509 442882 SGTC_602 3130-1533 38.1 µM 0.0720474945695143 0.467554322024526 no 1548 0.471282055415383 524 720941 SGTC_2986 9022445 71.43 µM 0.0716687542498431 0.467709954313869 no 1549 0.471432761346761 526 6459286 SGTC_633 0437-0093 97.7 µM 0.0711356449238595 0.467929028402628 no 1550 0.471644899734807 509 2831118 SGTC_169 k015-0017 16.025 µM 0.0696016069150494 0.468559474595067 no 1551 0.472255378955646 516 1840002 SGTC_2232 chlorophetanol 41.5365 µM 0.0693934348547911 0.468645033529713 no 1552 0.472338227275378 522 15907 An antifungal of unknown mechanism. YFR051C RET2 SGTC_750 4073-0104 132 µM 0.0659797782500743 0.470048253665533 no 1553 0.473696962492994 516 22330957 SGTC_1509 1326-1131 80 µM 0.0655236137095469 0.470235793549481 no 1554 0.473878552855403 517 768313 SGTC_2185 6113692 200 µM 0.0651977767990148 0.470369756749169 no 1555 0.474008265611062 508 874150 SGTC_1279 0874-0590 65.2 µM 0.065178730064741 0.47037758764627 no 1556 0.474015848030761 502 3523074 SGTC_2768 sulfasalazine 50.2 µM 0.0651552154594766 0.470387255484993 no 1557 0.474025209102896 521 5384001 An antioxidant and salicylic acid derivative. SGTC_1822 st052468 42 µM 0.0650469912276973 0.470431751222707 no 1558 0.474068292929955 517 2873678 SGTC_1050 3232-1156 69.3 µM 0.0648399425856804 0.470516879046717 no 1559 0.474150719380677 525 700529 SGTC_372 0155-0182 15.9 µM 0.0631515668243926 0.471211102850632 no 1560 0.474822905911729 517 771486 SGTC_2687 chenodiol 100 µM 0.0627247037900236 0.471386633689804 no 1561 0.474992862672105 518 5702181 A cholesterol synthesis inhibitor. SGTC_1042 0350-0096 82 µM 0.0611493767075156 0.472034473596355 no 1562 0.47562012288457 493 3122515 SGTC_2475 5812728 15.03 µM 0.0588064817136782 0.472998105647545 no 1563 0.476553122868329 516 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2 SGTC_993 3909-8757 62.7 µM 0.0585470919392756 0.473104802409017 no 1564 0.476656426427709 517 4288324 YLR208W SEC13 SGTC_1080 nisoldipine 24.4 µM 0.0563321577504334 0.474015965881202 no 1565 0.477538600659542 529 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class. SGTC_232 clozapine 119 µM 0.0562903859838481 0.47403315096693 no 1566 0.477555238783029 508 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_782 0083-0095 30.5 µM 0.0558650890556597 0.474208122710497 no 1567 0.477724641137753 497 3591729 An indicator and reagent. SGTC_1408 3909-7976 48.8 µM 0.0555848277470651 0.474323427957476 no 1568 0.477836275760442 527 24152374 SGTC_2965 9082772 38.63 µM 0.0555488396200291 0.474338234366636 no 1569 0.477850610797863 507 16459634 SGTC_2603 homopterocarpin 100 µM 0.0552668352597451 0.474454259189024 no 1570 0.477962941698127 517 101795 A weak amylase inhibitor. SGTC_2110 5483698 200 µM 0.0539227177363407 0.475007297963241 no 1571 0.478498368429237 518 2848765 YHR062C RPP1 SGTC_1768 st044301 37.178 µM 0.0528679853128378 0.475441302665485 no 1572 0.478918546363901 537 3931349 SGTC_31 0508-1974 57.237 µM 0.0524156327399139 0.475627447121311 no 1573 0.479098759057176 525 6810525 SGTC_3055 9094636 49.47 µM 0.0508966440815365 0.47625255425163 no 1574 0.47970393984041 533 25236176 SGTC_751 0833-0568 350 µM 0.0505337427731724 0.476401907191848 no 1575 0.479848530449768 528 6954252 SGTC_272 doxorubicin 8.13 µM 0.0492926422522526 0.476912710140738 no 1576 0.480343041511945 509 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_1733 st037357 54.9 µM 0.048376408307443 0.477289831301434 no 1577 0.480708130364932 533 1272339 YGL099W LSG1 SGTC_1942 st076330 65.2 µM 0.0483675749833384 0.477293467190117 no 1578 0.480711650231006 524 24208414 SGTC_1627 st003713 25.6 µM 0.0466707304017356 0.477991940883529 no 1579 0.481387829335883 516 16195070 YER133W GLC7 SGTC_1388 3346-4487 254 µM 0.0462624110424825 0.47816002792881 no 1580 0.481550549428301 525 3345614 SGTC_539 4859-0462 2.54 µM 0.0453403385660331 0.478539618686627 no 1581 0.481918017478561 493 46499474 YNL221C | YBR257W POP1 | POP4 SGTC_345 1362-0200 395 µM 0.0447257971889677 0.478792618554928 no 1582 0.482162935543001 505 1419823 SGTC_1358 1509-0022 2.48 µM 0.0445399464778809 0.478869132918811 no 1583 0.482237005435569 516 3258434 SGTC_459 nigericin 15.3 µM 0.0443918336236228 0.478930111240705 no 1584 0.482296035528889 519 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification. SGTC_1301 naphtanilide LB 4.81 µM 0.0437881037589277 0.47917867297207 no 1585 0.482536654907458 527 67238 An a1-adrenergic receptor antagonist or alpha blocker. SGTC_1925 st057770 10.1 µM 0.0423284745828619 0.47977965042982 no 1586 0.483118423094014 491 5989122 SGTC_360 0957-0399 1.01 µM 0.0419949475755195 0.47991698099685 no 1587 0.483251362908195 517 6752301 YPR165W RHO1 SGTC_1465 k213-0056 144 µM 0.040815743496587 0.480402540185092 no 1588 0.483721394161146 523 24048857 YMR208W ERG12 SGTC_3202 9113761 49.47 µM 0.039789184122642 0.480825268782176 no 1589 0.484130599611941 538 4798415 SGTC_2105 5350118 200 µM 0.0394456296406269 0.480966746494854 no 1590 0.484267550502706 523 2133313 SGTC_1528 arabinosylhypoxanthine 74.6 µM 0.0393303842953024 0.481014205729105 no 1591 0.484313491093262 527 804 An inhibitor of viral and cellular DNA polymerases. SGTC_306 1672-3436 11.6 µM 0.0391473910588177 0.481089564803589 no 1592 0.484386438652274 530 6797378 SGTC_1817 st052116 64.4 µM 0.0390524188906677 0.481128675885546 no 1593 0.484424298114711 511 4361398 SGTC_2798 7813637 45.45 µM 0.0390141430512822 0.48114443854949 no 1594 0.484439556337239 532 956368 SGTC_1339 1486-1321 22.7 µM 0.0381905248760429 0.481483626103123 no 1595 0.484767887719926 509 3469382 SGTC_1127 asiatic acid 681.4 nM 0.0381734885515609 0.481490642250457 no 1596 0.48477467927767 516 470603 A kinase inhibitor which arrests cells at G2/M. SGTC_1277 0873-0036 22 µM 0.0380355349040162 0.481547456542298 no 1597 0.484829674880334 519 5965735 SGTC_1725 st036284 20.55 µM 0.0380070906982208 0.481559170939651 no 1598 0.484841014277465 497 707914 SGTC_97 0535-0701 19.132 µM 0.0366515474839682 0.482117453068311 no 1599 0.485381421083481 512 2832013 YGL099W LSG1 SGTC_1243 0416-0003 5.65 µM 0.0361501350849939 0.482323969320693 no 1600 0.485581323206096 526 2141977 SGTC_565 1418-0001 44.5 µM 0.0359566758055231 0.482403650482918 no 1601 0.485658452147848 519 2862145 SGTC_2919 7978188 46.38 µM 0.0353041941542829 0.482672396937234 no 1602 0.485918589482881 532 2980291 SGTC_1650 st011916 45.8 µM 0.0352381198621271 0.482699612291858 no 1603 0.485944932920231 533 242528 SGTC_487 nimodipine 119 µM 0.0350119151497282 0.482792784409864 no 1604 0.486035119891829 534 4497 L-type voltage-gated calcium channels inhibitor SGTC_1256 0570-0116 285 µM 0.0341068024955133 0.483165603249904 no 1605 0.48639599201777 517 410638 SGTC_1355 1499-0035 1.68 µM 0.03157399608556 0.484208951622755 no 1606 0.487405890582443 528 1548538 SGTC_770 0389-1121 67.2 µM 0.0307944696440298 0.484530086944081 no 1607 0.487716725457366 511 6753108 SGTC_1185 1319-0113 81.3 µM 0.0301914630745533 0.484778509668794 no 1608 0.487957178454536 535 4672763 SGTC_2129 girgensonine 121.053 µM 0.0290449365365715 0.485250864431512 no 1609 0.488414375761752 542 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_1177 0983-0204 23.6 µM 0.0287989734963676 0.48535220088285 no 1610 0.488512459786442 531 766818 SGTC_1469 k284-2957 126 µM 0.0287354578707355 0.485378369391603 no 1611 0.48853778837243 530 23884841 SGTC_2146 5545642 200 µM 0.0285796613185131 0.485442558011681 no 1612 0.488599916687334 536 825326 SGTC_1659 st012954 42.1 µM 0.0284869636260482 0.485480749902196 no 1613 0.488636882665153 526 24207262 SGTC_2000 st075254 36.4 µM 0.0283344824551319 0.485543573159948 no 1614 0.488697689305562 519 17234175 SGTC_86 0417-1630 471.922 µM 0.0274766010461306 0.485897032656254 no 1615 0.489039801230188 530 3634867 SGTC_1605 st000082 49.1 µM 0.027336281054907 0.485954847575368 no 1616 0.48909575978788 532 1114022 SGTC_554 4483-2211 187 µM 0.0271508986648819 0.486031229645233 no 1617 0.489169689220405 532 747107 SGTC_77 0828-0286 12.516 µM 0.0266419972487731 0.486240912076961 no 1618 0.489372638087856 504 745345 SGTC_3251 9135047 49.47 µM 0.0262658694566951 0.48639589029748 no 1619 0.489522638870814 534 17682963 SGTC_1721 st082152 9.2685 µM 0.0261058646368081 0.486461818680319 no 1620 0.489586449677193 535 5296051 SGTC_1774 st048371 48.465 µM 0.0261030449847832 0.486462980493007 no 1621 0.489587574172397 543 4242727 SGTC_2679 rapamycin 1 nM 0.0258560403227113 0.486564757024993 no 1622 0.489686081526582 535 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2 SGTC_2437 5741531 144.16 µM 0.0256424334052158 0.486652772957308 no 1623 0.48977127011151 541 2262990 SGTC_2444 5485484 36.41 µM 0.0252456448469122 0.486816269922662 no 1624 0.489929514610792 528 6790631 SGTC_2855 9016525 58.44 µM 0.0246641562676019 0.487055876638913 no 1625 0.490161422766079 531 43811474 SGTC_2055 5235184 200 µM 0.0240021212963948 0.487328678781595 no 1626 0.490425458322862 540 2836034 SGTC_2409 alverine citrate 63.97 µM 0.0231213301485435 0.487691632090201 no 1627 0.490776745617622 511 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_2429 5902844 64.44 µM 0.0206768276497597 0.488699006532715 no 1628 0.491751726962472 537 1927790 YGL093W | YPR107C SPC105 | YTH1 SGTC_2088 5278280 127.392 µM 0.0204133463770658 0.488807591040854 no 1629 0.491856818599977 538 791502 SGTC_594 1487-1584 10.8 µM 0.0200525065611399 0.488956299781199 no 1630 0.492000743395865 539 5013332 SGTC_1057 3448-5381 134 µM 0.0191871743305524 0.489312925362478 no 1631 0.492345894561157 536 5497911 SGTC_3344 9148862 3.898 µM 0.0181335330768173 0.489747169424403 no 1632 0.492766163409185 534 4905352 SGTC_2929 9013348 24.6 µM 0.0178073111905566 0.489881619872189 no 1633 0.492896286099478 535 2995952 SGTC_2812 7970281 58.44 µM 0.0177967866630191 0.489885957514058 no 1634 0.492900484113239 535 2233435 SGTC_343 4130-2827 29.8 µM 0.0174411161503447 0.490032546391208 no 1635 0.493042354096011 534 1118244 SGTC_1124 fisetin 1.16336 µM 0.0161780876788584 0.490553111745797 no 1636 0.49354615833798 529 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster. SGTC_2598 perillyl alcohol 100 µM 0.0158546164104421 0.490686435145144 no 1637 0.493675188152231 535 10819 An apoptosis inducer. SGTC_2120 5538279 151.968 µM 0.0150616590118873 0.491013268469446 no 1638 0.493991494583181 539 2058197 SGTC_667 1498-1044 59 µM 0.0143798985052377 0.491294274592647 no 1639 0.494263448201173 540 6739982 SGTC_700 3453-2283 142 µM 0.0139240107160723 0.491482183555309 no 1640 0.494445302902172 540 565664 SGTC_1757 st041620 31.8375 µM 0.0136919084765576 0.491577852762413 no 1641 0.494537889471996 537 5289815 SGTC_2472 5377652 49.4 µM 0.0133144648816892 0.491733430619281 no 1642 0.49468845395227 535 1610903 SGTC_733 4069-0007 56.1 µM 0.013035301178807 0.49184849945886 no 1643 0.494799814490878 540 5717425 YNL287W SEC21 SGTC_1888 azatryptophan 97.5 µM 0.0124659122087942 0.492083198710675 no 1644 0.495026949357629 535 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides SGTC_11 0438-0307 1.3 µM 0.012406624725998 0.492107636869978 no 1645 0.495050599812242 534 4011476 SGTC_2187 6125751 200 µM 0.01225367359778 0.492170683097571 no 1646 0.495111613845827 541 874498 SGTC_3018 9082602 49.47 µM 0.011931916116444 0.492303311689483 no 1647 0.495239967123356 537 17332089 SGTC_1389 3405-0187 19 µM 0.0118262592139387 0.492346863702907 no 1648 0.495282115155045 543 799890 SGTC_2513 baicalein 25.65 µM 0.0109213485133902 0.492719873616965 no 1649 0.495643098931364 540 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2 SGTC_419 nsc-638432 893 µM 0.0089560750014776 0.493529993275394 no 1650 0.496427090780131 530 368090 SGTC_1862 st057513 3.81 µM 0.00801317347812334 0.493918683234561 no 1651 0.496803240510582 543 5393163 SGTC_2298 7976326 193.81 µM 0.00702182311723377 0.494327351357566 no 1652 0.497198720893032 545 2235818 SGTC_3039 9090270 49.47 µM 0.00686947868204863 0.494390153420939 no 1653 0.497259496063375 541 17173750 SGTC_2074 5212007 75.395 µM 0.00496912334895358 0.49517356201601 no 1654 0.498017614757814 547 758611 SGTC_984 1492-0255 2.91 µM 0.00447763872698458 0.495376176368512 no 1655 0.498213686564485 548 1585198 SGTC_3279 9140807 49.47 µM 0.00402586310423424 0.49556242175423 no 1656 0.498393917331065 544 45595718 SGTC_568 1193-0097 7.48 µM 0.0038881979013203 0.495619174698028 no 1657 0.49844883737103 544 3646150 SGTC_1893 st059353 36.1 µM 0.00296439138115436 0.496000019286214 no 1658 0.498817380674468 546 3112488 SGTC_52 0329-0193 875 nM 0.00239346665259915 0.496235388156886 no 1659 0.499045145867223 546 3739292 SGTC_1354 1498-1681 81 µM 0.00233960568302061 0.496257592896494 no 1660 0.499066633225079 544 5754243 SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM 0.00116869296470653 0.496740316476139 no 1661 0.499533759069706 547 6708561 SGTC_119 0121-0043 24.815 µM 0.00113659249654049 0.49675355037064 no 1662 0.499546565295171 545 1092378 SGTC_1646 st011709 75.6 µM 0.000808312967236729 0.496888888682102 no 1663 0.499677529816688 547 5757843 SGTC_3213 9129884 49.47 µM 0.00058163006934994 0.49698234242141 no 1664 0.499767963186866 547 17190742 SGTC_524 r073-0010 27.8 µM 0.000450330212451239 0.497036473015095 no 1665 0.499820344244183 548 2772106 SGTC_1884 5633444 25 µM 0.000411000528643046 0.497052687355191 no 1666 0.499836034516473 548 5724239 SGTC_3253 9135987 49.47 µM 0.000283378339300314 0.497105301836032 no 1667 0.499886948400616 548 4182430 SGTC_51 1013-0126 23.419 µM 0.000257283674867929 0.497116059824309 no 1668 0.499897358665171 547 1627850 SGTC_1761 st044296 37 µM 0.000184473910356599 0.497146076952288 no 1669 0.499926405557945 547 1826700 SGTC_511 blebbistatin 171 µM -7.52100451773145e-05 0.497253136439074 no 1670 0.499969995533096 548 3476986 A myosin inhibitor. SGTC_990 3985-0011 41.3 µM -0.00135137761465982 0.497779262719592 no 1671 0.499460878496817 549 5399565 YGL099W LSG1 SGTC_705 1124-0212 310 µM -0.00159657617955436 0.497880351332531 no 1672 0.499363058528694 549 9554485 SGTC_3151 9099821 49.47 µM -0.00445464762211135 0.499058663784983 no 1673 0.498222858596817 553 17174189 SGTC_2752 diclazuril 33.15 µM -0.00455905151812086 0.49910170715748 no 1674 0.49818120789148 553 456389 An antifungal agent for coccidioides. YHR062C RPP1 SGTC_1129 3453-1384 223 µM -0.0045663263040491 0.499104706388101 no 1675 0.498178305702001 554 1084452 SGTC_2932 9016711 44.54 µM -0.00534601103848078 0.49942615312675 no 1676 0.497867260324153 553 7117328 SGTC_1529 apigenin 74 µM -0.00673790268617023 0.5 no 1677 0.497311986076278 553 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_1151 3909-8316 15.3 µM -0.00740689576419088 0.499724188525387 no 1678 0.497045103131806 552 800431 SGTC_1667 st014849 34.6 µM -0.00775481319074642 0.499580749688228 no 1679 0.496906308149251 550 5348460 SGTC_337 1315-0038 354 µM -0.00841684671007201 0.499307807738548 no 1680 0.496642203625975 554 1626437 SGTC_1692 fluoroquinolonic acid 71 µM -0.00871747407454484 0.499183865746406 no 1681 0.496522275061327 554 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2 SGTC_1648 st011736 69.8 µM -0.0088985702480625 0.499109203849426 no 1682 0.496450030943439 554 2855514 SGTC_2909 7941780 10.49 µM -0.00911049574107208 0.499021831754201 no 1683 0.496365488331636 553 1243215 SGTC_2657 nystatin 74.44 µM -0.00931164613699102 0.498938902031526 no 1684 0.496285244338296 553 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_977 1348-1378 135 µM -0.00974049162553155 0.498762098970453 no 1685 0.496114167504913 554 X977 SGTC_927 2425-1185 123 µM -0.0114395237765068 0.498061630098083 no 1686 0.495436389832506 561 730375 SGTC_2715 st079500 56.4 µM -0.0122424795491211 0.49773059326883 no 1687 0.49511607929017 553 28246688 SGTC_2880 9042983 58.44 µM -0.012648511351681 0.497563197978944 no 1688 0.49495410858239 554 6464714 SGTC_2117 5521686 200 µM -0.0138880247279266 0.497052184872701 no 1689 0.494459657846317 556 803312 SGTC_2335 9018011 154.17 µM -0.0140901200577047 0.496968867642517 no 1690 0.494379041363207 556 6458208 SGTC_1855 st056195 39.6 µM -0.0146695652644445 0.496729982265718 no 1691 0.494147900073215 554 4028379 SGTC_951 1171-0579 82.7 µM -0.016581315395482 0.495941842064222 no 1692 0.493385315332383 556 1616050 YPR165W | YDR526C RHO1 | YDR526C SGTC_1020 4335-0961 93.3 µM -0.0178147331952301 0.49543336010519 no 1693 0.492893325617626 581 669075 SGTC_2816 7982706 58.44 µM -0.0182251532578398 0.495264164218252 no 1694 0.492729618284621 563 2981853 SGTC_2246 7293507 91.5585 µM -0.0196235639643624 0.494687675247908 no 1695 0.492171833062994 554 887656 SGTC_1877 wortmannin 25 µM -0.0196627081101537 0.49467153839138 no 1696 0.492156219820705 563 312145 A covalent inhibitor of PI 3-kinase. SGTC_1887 st057648 70.8 µM -0.0205536065136467 0.49430427516156 no 1697 0.4918008746388 558 688672 SGTC_2382 9035899 200 µM -0.0206322393155861 0.494271859866858 no 1698 0.491769511340286 559 6462679 SGTC_1219 1469-0211 33.1 µM -0.0208906548328182 0.494165331879782 no 1699 0.4916664406809 565 6822282 SGTC_464 bw-b 70c 158 µM -0.0210391869438109 0.494104101894705 no 1700 0.491607197962727 575 5353454 SGTC_2958 9077254 16.72 µM -0.0220409700386137 0.493691136550173 no 1701 0.491207637051009 563 16457351 SGTC_703 3875-0075 71.8 µM -0.0224873056313795 0.493507145646322 no 1702 0.491029619039789 560 2850814 SGTC_1273 0849-0096 14.1 µM -0.0225610333471751 0.493476753335188 no 1703 0.491000213396977 563 5286025 SGTC_1496 4469-0713 57.4 µM -0.0225734446243628 0.493471637116414 no 1704 0.490995263274413 564 746691 SGTC_1395 3486-0190 4.35 µM -0.022786607777554 0.493383766446811 no 1705 0.490910245348867 568 6748079 SGTC_2588 indole-3-carbinol 100 µM -0.0230583140612469 0.493271763441604 no 1706 0.490801878698569 557 3712 Induces cell cycle arrest. SGTC_619 1652-1634 108 µM -0.0255268135143205 0.492254221798072 no 1707 0.489817380680582 562 5400454 SGTC_2604 4'-hydroxychalcone 11.32 µM -0.0257662268569475 0.49215553565536 no 1708 0.489721899982036 555 5282362 SGTC_1502 4534-4282 27.7 µM -0.0258441742173347 0.492123405868808 no 1709 0.489690813836326 559 3278949 SGTC_2571 chrysanthemic acid 100 µM -0.0269209309134633 0.491679573672659 no 1710 0.48926139955584 574 2743 An insecticide. SGTC_763 3453-1109 128 µM -0.0273263378003476 0.491512470196795 no 1711 0.48909972509121 556 1560353 SGTC_535 2293-4129 48.2 µM -0.0273841554689001 0.491488638622227 no 1712 0.48907666780728 577 396118 YIL048W NEO1 SGTC_876 0720-0963 56.8 µM -0.0281654261747841 0.491166613585579 no 1713 0.488765106096792 558 765861 SGTC_2884 9058502 51.95 µM -0.0290587499896593 0.490798409440109 no 1714 0.488408867316358 577 6471554 SGTC_383 2324-0395 7.37 µM -0.0293807174761665 0.490665704973131 no 1715 0.488280475695254 566 3146421 SGTC_1683 st010134 710 nM -0.0296477844972532 0.490555629465635 no 1716 0.488173977763957 584 3818134 SGTC_3143 9086658 49.47 µM -0.030341891310831 0.490269546760749 no 1717 0.487897193752414 571 25236626 SGTC_982 1491-0518 27.5 µM -0.0332824624433073 0.489057619769041 no 1718 0.486724669477351 565 3091256 SGTC_2447 5741742 33.78 µM -0.033422297261733 0.488999990674564 no 1719 0.486668914475089 567 1776504 SGTC_501 nsc-95397 161 µM -0.0352151160694474 0.488261150222221 no 1720 0.485954104413455 565 262093 SGTC_89 0302-0250 142.109 µM -0.0356005402590005 0.4881023178269 no 1721 0.485800438765911 567 4203518 YLR208W SEC13 SGTC_1461 k072-0203 53.8 µM -0.0361316954228057 0.487883433139692 no 1722 0.485588674764235 562 5418714 SGTC_669 0108-0021 26.2 µM -0.0362115158610742 0.487850540105484 no 1723 0.485556851841707 585 17201 SGTC_3249 9135183 49.47 µM -0.0370451626308773 0.48750700936662 no 1724 0.485224497931584 570 4902779 SGTC_1516 st013856 110 µM -0.037095203900784 0.487486388557763 no 1725 0.485204548065503 579 5281404 A mutagen and neurotoxin. SGTC_3282 9108498 15.4605 µM -0.037165398422024 0.487457463133085 no 1726 0.485176563800167 579 16459645 SGTC_623 k072-0108 16.9 µM -0.0373871076670083 0.487366102675224 no 1727 0.485088176038144 577 5382803 SGTC_2570 licareol 100 µM -0.0375534386045955 0.487297562573674 no 1728 0.485021866161264 582 443158 SGTC_589 1227-0070 34.1 µM -0.0383726143769515 0.486960009773736 no 1729 0.484695297728327 559 2841384 SGTC_1239 0337-0584 35.4 µM -0.0391678972546964 0.486632311309166 no 1730 0.484378264133212 570 914301 YML130C ERO1 SGTC_2646 retinol 96.75 µM -0.0395061101985532 0.486492952471925 no 1731 0.48424344104375 572 445354 A vitamin A analog and teratogen. SGTC_1292 0kpi-0043 232 µM -0.0406103707039398 0.486037959401848 no 1732 0.483803258176138 575 3333905 SGTC_687 k029-0044 34.9 µM -0.0411412704162671 0.485819217008179 no 1733 0.483591636702628 565 5829338 SGTC_3212 9128307 49.47 µM -0.0412436726067756 0.485777025535429 no 1734 0.483550818784265 596 27243542 SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM -0.0413807090746136 0.485720564390866 no 1735 0.48349619577569 583 689007 SGTC_1 0258-0098 57.368 µM -0.0419462460393019 0.485487557453981 no 1736 0.483270774905162 550 6790032 YDR047W HEM12 SGTC_1520 flindersine 88 µM -0.0419716715643001 0.48547708199688 no 1737 0.48326064051324 577 68230 Flindersine is a natural alkaloid of the quinoline subtype. SGTC_1031 k035-0009 16 µM -0.0420488770345811 0.485445272977026 no 1738 0.483229867154243 567 5180959 SGTC_1420 4'-methoxyflavone 42 µM -0.0426131005218655 0.485212813049228 no 1739 0.483004976135367 570 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13 SGTC_3295 9122362 53.5725 µM -0.0427581953986986 0.485153034807411 no 1740 0.482947144364996 574 4730473 SGTC_391 gliotoxin 8.33 µM -0.0450004203426923 0.484229294467189 no 1741 0.482053486955093 572 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion SGTC_1383 3049-0032 20.7 µM -0.0450648986077813 0.484202732270172 no 1742 0.482027789918231 586 712864 SGTC_2876 9059903 25.97 µM -0.0456923097256833 0.483944270282083 no 1743 0.481777746679516 560 6916095 SGTC_1423 4048-0112 5.59 µM -0.0465040879594487 0.483609868293934 no 1744 0.481454237946445 566 X1423 SGTC_628 1636-0253 16 µM -0.0477941276388576 0.483078476239664 no 1745 0.480940158337571 575 4456143 SGTC_2066 5222451 176 µM -0.0480908000528362 0.482956275406396 no 1746 0.480821939108995 568 2281147 SGTC_205 1486-1330 71.903 µM -0.0482755890673662 0.482880160706708 no 1747 0.480748304483698 572 4118834 SGTC_36 0335-0881 14.2 µM -0.0484656354682024 0.482801881137478 no 1748 0.480672575583186 568 23828853 SGTC_2654 protoveratrine a 100 µM -0.0487170351010872 0.482698331366408 no 1749 0.480572399973661 578 5702278 A heart drug and vasodilator. SGTC_2887 9044784 58.44 µM -0.0505989535815737 0.481923219699771 no 1750 0.479822548339955 575 6465546 SGTC_2188 6126565 140.678 µM -0.0511604221459898 0.481691978982167 no 1751 0.479598844536692 561 874518 SGTC_2718 lomofungin 53.02 µM -0.0523552157753776 0.481199924058391 no 1752 0.479122828889501 580 5351222 A RNA synthesis inhibitor. SGTC_1625 st003711 30.1 µM -0.0524959152592283 0.481141981299689 no 1753 0.479066774999935 583 24207034 YER133W GLC7 SGTC_1583 clindamycin 39.6 µM -0.0525000874525622 0.481140263116152 no 1754 0.479065112827697 587 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis. SGTC_1539 benzyladenosine 56 µM -0.0527424754482321 0.481040444024219 no 1755 0.478968547795044 578 92208 A nucleotide analog. SGTC_1540 guanosine 70.6 µM -0.0528995449777308 0.480975761018761 no 1756 0.478905973472774 570 6802 Guanosine is a purine nucleoside SGTC_2517 totarol 10 µM -0.0529300059138846 0.480963216919303 no 1757 0.478893838318395 573 460178 An antibacterial membrane disruptor. YGL001C ERG26 SGTC_1671 st016596 74.5 µM -0.0532311560267525 0.480839201492165 no 1758 0.478773865939157 574 2829167 SGTC_415 dibenzyl ketone 100 µM -0.0549057597627285 0.480149623763855 no 1759 0.478106771587976 574 7593 SGTC_2289 7946404 165.07 µM -0.055403799211213 0.479944549650709 no 1760 0.477908384577889 579 1246120 YPR165W RHO1 SGTC_1966 st070145 16.1 µM -0.0554732115152633 0.479915968666922 no 1761 0.477880735596268 573 3748532 SGTC_63 0099-0242 26.702 µM -0.0562318505824899 0.479603600683525 no 1762 0.477578554100169 572 3898502 YLR359W ADE13 SGTC_2758 dehydroepiandrosterone 69.35 µM -0.0563503956703814 0.479554791128512 no 1763 0.477531336321061 589 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem] SGTC_2253 7938677 135.83 µM -0.0566312230687888 0.479439164952747 no 1764 0.47741948101814 587 2301972 SGTC_3315 9136395 68.55 µM -0.058157355256267 0.47881083501062 no 1765 0.476811644385552 576 16876844 SGTC_591 4299-0174 154 µM -0.0599133554356092 0.47808793045207 no 1766 0.47611232145248 577 5509088 SGTC_401 neomycin 50 µM -0.0626412581003596 0.476965060019217 no 1767 0.47502608734919 577 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis. SGTC_1479 0549-0158 134 µM -0.0636193621559026 0.476562492908658 no 1768 0.474636657100684 588 5440202 SGTC_1052 3253-3998 198 µM -0.0643733304195955 0.476252191692038 no 1769 0.474336482606284 595 5450317 SGTC_2528 xanthyletin 44.79 µM -0.0651855209874158 0.475917944772305 no 1770 0.474013144593747 574 65188 An natural product with antifungal activity of unknown mechanism. SGTC_1825 st052143 62.6 µM -0.0659908472288997 0.475586539510812 no 1771 0.473692556212398 591 674173 SGTC_90 0870-0863 4.608 µM -0.0660481761617935 0.475562948334181 no 1772 0.473669735065262 584 1738164 SGTC_1558 st069300 45.6 µM -0.0662169008448851 0.475493517680493 no 1773 0.473602570688339 581 24208000 SGTC_884 0851-0618 334 µM -0.0695495342500928 0.474122285413484 no 1774 0.472276102723204 584 9642473 SGTC_2092 5303694 80.6725 µM -0.0703862685276761 0.473778053514949 no 1775 0.471943110134294 597 1963699 SGTC_1824 st053723 68.6 µM -0.0718014948772791 0.473195875076804 no 1776 0.471379941576545 601 675225 SGTC_2388 9080168 200 µM -0.0722038742852179 0.473030359575131 no 1777 0.471219830995003 586 15943073 SGTC_2147 5545932 89.7195 µM -0.0732135008845287 0.472615078435319 no 1778 0.470818111534423 590 797404 SGTC_2265 7929201 200 µM -0.0736182798364523 0.472448592478326 no 1779 0.470657062700721 589 1265108 SGTC_921 1561-0023 372 µM -0.0745184745150984 0.472078358872772 no 1780 0.470298920749176 579 24050882 SGTC_17 0960-0276 49.807 µM -0.0746206629947259 0.472036332139058 no 1781 0.470258266632436 579 6821114 SGTC_695 3505-6186 243 µM -0.0756327724546098 0.471620101961295 no 1782 0.469855631240235 587 1819379 SGTC_2046 4110841 106 µM -0.075876405793281 0.471519912323111 no 1783 0.469758714092139 587 44119630 YMR134W ERG29 SGTC_316 k060-0003 58.6 µM -0.0760182835519849 0.471461568587499 no 1784 0.469702276057794 602 6152314 SGTC_2649 anisomycin 9.56 µM -0.0779394875123932 0.470671581566121 no 1785 0.468938094218252 611 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_1309 pyrazolanthrone 13.4 µM -0.0785763575847956 0.470409729901901 no 1786 0.46868479664775 600 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14 SGTC_223 busulfan 5 mM -0.0788456845833269 0.470298998877666 no 1787 0.468577683042703 586 2478 A DNA alkylator. SGTC_3208 9114115 49.47 µM -0.0789307113998864 0.470264041453478 no 1788 0.468543867637013 592 650895 SGTC_1046 2001-0062 216 µM -0.0795899321428002 0.469993021119362 no 1789 0.468281701400151 578 739778 SGTC_847 0342-0274 5.54 µM -0.0802173821533885 0.469735075350836 no 1790 0.468032182876203 599 18097 SGTC_2739 tacrine 100.86 µM -0.0803442157054868 0.469682935401098 no 1791 0.467981746403594 586 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders. SGTC_1296 1068-0102 11.9 µM -0.0818345759392374 0.46907030304364 no 1792 0.467389130324956 602 767053 SGTC_2161 5662504 8.5105 µM -0.0823049323764783 0.468876971919245 no 1793 0.467202116130575 577 2859334 SGTC_251 melphalan 456.522 µM -0.0823959599399518 0.468839557605719 no 1794 0.467165924314267 595 460612 A DNA alkylator. SGTC_3194 9111903 49.47 µM -0.0824768317523523 0.468806317758175 no 1795 0.4671337705694 590 17087251 SGTC_839 0122-0028 230 µM -0.0831779320317198 0.468518161394569 no 1796 0.466855029805693 593 759448 SGTC_2344 7990960 76.95 µM -0.08369331919524 0.468306344729977 no 1797 0.46665013450998 601 140813 SGTC_1983 st071813 46.9 µM -0.0839346199270433 0.468207176701746 no 1798 0.466554206973412 602 11838595 SGTC_1381 2324-0066 62.1 µM -0.0857252243466318 0.46747134910445 no 1799 0.465842424903674 596 10885928 SGTC_2122 5258151 111.688 µM -0.0863073769261554 0.467232144241879 no 1800 0.465611037210695 596 2173356 SGTC_54 0159-0055 9 µM -0.0867776240395944 0.467038929657385 no 1801 0.465424136973182 599 3319099 SGTC_2809 7964133 12.99 µM -0.0871851711463498 0.466871483458955 no 1802 0.465262163090607 606 1253665 SGTC_1453 4237-0541 195 µM -0.0872354953793515 0.466850807478515 no 1803 0.465242162828554 579 739892 SGTC_1226 3909-7979 35.4 µM -0.0873865241467568 0.466788757038475 no 1804 0.465182140286599 582 6615510 SGTC_1103 duloxetine 36.1 µM -0.0877296485310798 0.466647786771978 no 1805 0.46504577717437 599 60835 A selective serotonin reuptake inhibitor. SGTC_409 arachidonic acid 100 µM -0.0885299944511772 0.466318986509251 no 1806 0.464727722900131 587 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes. SGTC_2186 6124449 200 µM -0.0891735637720771 0.466054610293142 no 1807 0.464471987356877 600 3834182 YLR033W RSC58 SGTC_3034 9090421 49.47 µM -0.0894128664890836 0.465956309317501 no 1808 0.464376899224182 588 17173761 SGTC_1415 3966-0071 78.1 µM -0.0897782793625137 0.465806208712751 no 1809 0.464231704516636 588 2893185 SGTC_1181 1222-0449 220 µM -0.090162122235372 0.465648542857967 no 1810 0.464079191884579 602 658318 SGTC_1839 st053978 48 µM -0.0907604452907218 0.465402788692031 no 1811 0.463841470183926 589 3788398 SGTC_2339 9000433 200 µM -0.0908859918776005 0.465351223577999 no 1812 0.463791590492349 581 2988954 SGTC_2143 5623677 140.463 µM -0.091229177710901 0.465210271569435 no 1813 0.463655245578209 591 5375313 SGTC_2282 7944268 200 µM -0.0916767032856863 0.46502647209028 no 1814 0.463477453756516 609 2970414 SGTC_1456 k015-0012 13 µM -0.0921593843586067 0.464828242555816 no 1815 0.463285703625249 607 2989616 SGTC_569 4130-2812 160 µM -0.0924401425944127 0.464712943570687 no 1816 0.463174173384838 604 743552 SGTC_2366 9070441 60.58 µM -0.0938159565641289 0.464147981059864 no 1817 0.462627678042577 600 6837235 SGTC_784 4579-0127 173 µM -0.0948066788099048 0.463741196827582 no 1818 0.46223419092382 591 1948547 SGTC_111 0083-0039 52.457 µM -0.0966647533827898 0.462978385801556 no 1819 0.461496315715955 584 759313 SGTC_3162 9099653 49.47 µM -0.0967495047131291 0.462943595347697 no 1820 0.461462662562151 581 25237511 SGTC_1409 3909-8004 61.9 µM -0.0982980172530634 0.462307980521127 no 1821 0.460847826280694 579 2119279 SGTC_1821 st053465 65.6 µM -0.0985996085960603 0.462184198075944 no 1822 0.46072809040144 608 675086 SGTC_1777 st045864 34.765 µM -0.099751701649724 0.46171137715942 no 1823 0.460270726608292 593 4691462 SGTC_179 1273-0063 6.77 µM -0.100078334625254 0.461577336255881 no 1824 0.460141067715743 621 3108139 SGTC_2238 6671620 73.2395 µM -0.101430162388098 0.461022631083448 no 1825 0.459604496906913 598 729941 SGTC_198 3454-2873 16.191 µM -0.101507746148043 0.460990797873915 no 1826 0.459573704392607 612 710957 SGTC_2134 5324836 1.464 µM -0.101810202832621 0.460866699973718 no 1827 0.459453663522957 580 699272 SGTC_394 menadione 8.33 µM -0.102343116393735 0.460648054956441 no 1828 0.459242166511193 591 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_3153 9100258 49.47 µM -0.102957591635041 0.4603959613944 no 1829 0.458998314497256 606 25236848 SGTC_1673 st016611 27.3 µM -0.103149071489354 0.460317408444905 no 1830 0.458922329639956 588 5226799 SGTC_3333 9141820 12.094 µM -0.103659014647075 0.460108216249831 no 1831 0.458719976473002 612 1939433 SGTC_2817 7995342 71.43 µM -0.103846932269652 0.460031130242999 no 1832 0.458645410609057 610 18879975 SGTC_1750 st081859 2.357 µM -0.103929518984853 0.45999725268145 no 1833 0.458612640594089 611 5291695 SGTC_545 4218-0007 221 µM -0.103996811993897 0.459969648903795 no 1834 0.458585939256784 605 2840508 SGTC_1958 st076513 41.9 µM -0.104078857056862 0.459935994054028 no 1835 0.458553384673193 618 732122 YGL099W LSG1 SGTC_676 falcarinol 140 µM -0.106752832286585 0.458839289068094 no 1836 0.457492533969096 603 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer. SGTC_1019 4262-0212 3.4 µM -0.10699690859221 0.458739199014033 no 1837 0.457395716131523 593 4677213 SGTC_491 tetrandrine 80.3 µM -0.107016216706853 0.458731281313856 no 1838 0.457388057282458 605 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_2041 5107442 45.335 µM -0.107914217190749 0.458363055390765 no 1839 0.457031869648274 596 793005 SGTC_1255 0566-0045 221 µM -0.108433041904986 0.458150327104219 no 1840 0.456826095998481 617 2788469 SGTC_1654 st012436 41.8 µM -0.110198735581861 0.457426448315875 no 1841 0.456125882513638 605 4323132 SGTC_791 1348-1292 225 µM -0.110864224575694 0.457153655304397 no 1842 0.455862007661973 597 5437054 SGTC_1609 st001574 46.4 µM -0.112241887622866 0.456588996735862 no 1843 0.455315808734669 606 3960012 SGTC_2968 9090663 33.37 µM -0.112361729908039 0.456539881469879 no 1844 0.455268299115175 657 25236811 SGTC_237 nikkomycin 200 µM -0.112403014618672 0.456522961806524 no 1845 0.455251932578613 612 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine. SGTC_186 3455-3465 67.277 µM -0.114849561350847 0.455520438300705 no 1846 0.454282182326646 590 755278 SGTC_582 0987-0078 156 µM -0.115444428068217 0.45527672181946 no 1847 0.454046432918007 589 1625765 SGTC_110 0850-0284 111.64 µM -0.11630935939839 0.454922390105312 no 1848 0.453703684115215 585 3906265 SGTC_98 0074-0023 107.663 µM -0.116384726016892 0.454891516767115 no 1849 0.45367381999996 645 3563821 SGTC_1222 0366-0074 1.18 µM -0.116705342462056 0.454760181827633 no 1850 0.453546778268852 616 286520 SGTC_1012 4112-3522 18 µM -0.117921484625331 0.454262055458559 no 1851 0.453064934874245 615 3112398 SGTC_2060 5238662 140 µM -0.118138983213562 0.454172976573235 no 1852 0.452978767789572 623 790130 SGTC_1201 1889-3372 45.9 µM -0.118278633854215 0.454115782366712 no 1853 0.452923443132653 607 5392199 SGTC_1268 0828-0275 2.46 µM -0.120808916023127 0.453079666065579 no 1854 0.451921193934478 621 745337 SGTC_1182 1222-0449 220 µM -0.121721177052228 0.45270618547724 no 1855 0.451559920541812 593 658318 SGTC_2627 acetyl isogambogic acid 100 µM -0.122216500951452 0.452503416875704 no 1856 0.451363779275064 630 6857789 A caspase activator and apoptosis inducer. SGTC_1288 0973-0013 65.5 µM -0.123045091420291 0.452164248097247 no 1857 0.451035695722497 601 4315430 SGTC_2321 7390090 138.78 µM -0.123321289329904 0.452051199137801 no 1858 0.450926341529948 610 649046 SGTC_1854 st056233 32.9 µM -0.123923300279825 0.451804807022077 no 1859 0.450688002096063 632 5393174 SGTC_1586 deoxycorticosterone acetate 53.7 µM -0.12396182016972 0.451789042163695 no 1860 0.450672752464908 587 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE. SGTC_2327 6189656 200 µM -0.124411595039597 0.451604970501773 no 1861 0.450494696580612 616 5349088 SGTC_3317 9138495 8.753 µM -0.124949792726251 0.451384725224003 no 1862 0.450281649163351 600 17020139 SGTC_1327 1436-0082 2.18 µM -0.126553556338561 0.450728510095666 no 1863 0.449646878976325 607 15992205 SGTC_557 1315-0110 16.2 µM -0.126688613997815 0.450673254408692 no 1864 0.449593428967142 597 6833801 SGTC_2415 st077333 57.7 µM -0.127876832062878 0.450187164060816 no 1865 0.44912322291725 586 2766255 SGTC_1480 1070-0044 41.2 µM -0.128606281690603 0.449888789118416 no 1866 0.44883459776023 595 3124987 SGTC_2448 5185112 27.17 µM -0.128928707489172 0.449756912704201 no 1867 0.448707030474513 600 5718189 SGTC_1686 st019653 115.5 µM -0.129332412141072 0.449591799989199 no 1868 0.448547312809901 613 97252 SGTC_1781 st038725 66.3 µM -0.131172160558109 0.448839465152913 no 1869 0.44781955915086 599 4270275 YIL048W NEO1 SGTC_1413 3910-0535 34.4 µM -0.131280818934862 0.448795036823755 no 1870 0.447776582366438 601 2876951 SGTC_2469 5655019 90.81 µM -0.131559599913274 0.448681051559442 no 1871 0.447666321146443 612 2788239 SGTC_1068 loratadine 26.9 µM -0.133290461990359 0.447973448605378 no 1872 0.446981835261477 619 3957 A H1 histamine antagonist. SGTC_285 1486-1325 46 µM -0.134847819130436 0.447336918524152 no 1873 0.446366098447058 607 22310230 SGTC_3020 9089140 49.47 µM -0.13522025532082 0.447184714746324 no 1874 0.446218866371424 602 17217859 SGTC_2128 5255449 168.493 µM -0.136176821548254 0.446793829803629 no 1875 0.445840749092753 605 736008 SGTC_387 norethindrone acetate 66.7 µM -0.137792588128569 0.446133691136011 no 1876 0.44520217114906 634 541197 SGTC_1380 2291-0730 164 µM -0.137995118540577 0.446050955667176 no 1877 0.445122137739599 619 2999191 SGTC_2651 TUB2.036 5 µM -0.138911711929311 0.445676548564163 no 1878 0.444759957959882 602 15992207 YFL037W TUB2 SGTC_43 0570-0105 72.5 µM -0.138966917489897 0.445653999918612 no 1879 0.444738145680545 604 1114046 YDL195W SEC31 SGTC_805 3852-0218 479 µM -0.139124742921671 0.44558953727864 no 1880 0.444675788168026 602 6615355 SGTC_2303 7774051 200 µM -0.139743616306309 0.445336776878836 no 1881 0.444431281835264 619 2953184 SGTC_2405 ticlatone 3.52 µM -0.139845429209696 0.445295196556735 no 1882 0.444391059314351 632 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W SGTC_9 0092-0002 10.449 µM -0.139889520885729 0.445277189732252 no 1883 0.444373640497955 611 759368 SGTC_1511 0906-3109 28.5 µM -0.140296076467157 0.445111159749304 no 1884 0.44421303209615 615 2882180 SGTC_877 0771-0151 33.1 µM -0.140855237075629 0.444882824352373 no 1885 0.443992152565618 638 6166523 SGTC_423 5-fluorouracil 457 µM -0.14125157300971 0.444720990111133 no 1886 0.443835602541964 611 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_1767 st044992 70.3 µM -0.143170361969249 0.443937629580119 no 1887 0.443077818187307 612 9600693 SGTC_3314 9135860 59.4275 µM -0.143345260097484 0.443866236901957 no 1888 0.44300875624991 602 25252478 SGTC_2273 7815444 169.05 µM -0.143445392765214 0.443825363989261 no 1889 0.442969217692191 644 2824616 SGTC_1616 st002734 56.1 µM -0.143619167469904 0.443754432729256 no 1890 0.442900602061085 604 4026101 SGTC_2666 tannic acid 100 µM -0.14377794976815 0.443689622636514 no 1891 0.44283790773826 609 16134267 A thiamine antagonist. SGTC_1131 3454-3128 32.3 µM -0.144153408103793 0.44353637798622 no 1892 0.442689665762393 592 710982 SGTC_40 0327-0103 19.753 µM -0.144757606311483 0.443289790083013 no 1893 0.442451127421075 624 409036 SGTC_1475 4092-1048 11.7 µM -0.146246506023798 0.442682228027043 no 1894 0.441863396850106 611 2881759 SGTC_3028 9087778 49.47 µM -0.146356377165418 0.442637399210029 no 1895 0.441820031200252 589 17217395 SGTC_1800 st050079 29.0735 µM -0.146704169232369 0.442495500487355 no 1896 0.441682763821459 620 3645560 SGTC_1869 3',7'-dimethoxyflavone 40.3 µM -0.147054676253821 0.442352501530197 no 1897 0.441544431983949 603 688664 SGTC_2103 5378138 10 µM -0.148404399546524 0.441801915188583 no 1898 0.441011814091997 605 244142 SGTC_1560 lithocholic acid 53.1 µM -0.149877435873657 0.441201154669781 no 1899 0.440430657088631 604 9903 A bile acid which acts as a detergent. SGTC_2573 2',4'-dihydroxychalcone 15.04 µM -0.150545538103949 0.440928721549281 no 1900 0.440167112939089 635 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_1735 st034310 56.75 µM -0.150698326810543 0.440866422575395 no 1901 0.440106846586558 589 871153 SGTC_24 0417-1663 219 µM -0.152028250240407 0.440324213676634 no 1902 0.439582327078769 642 4329390 SGTC_2089 5281248 129.67 µM -0.15240643293977 0.440170049228299 no 1903 0.439433191799003 607 2737878 SGTC_1435 4092-0789 56.7 µM -0.152549847529022 0.440111589297335 no 1904 0.439376638907362 605 2248285 SGTC_1980 st071811 45.7 µM -0.153328388339894 0.439794256378092 no 1905 0.439069657351371 654 4974850 SGTC_536 3852-0578 10.6 µM -0.153984547931269 0.439526836020325 no 1906 0.43881095961657 619 2869208 SGTC_2436 5633522 8.09 µM -0.155539929792093 0.438893044620159 no 1907 0.438197838769295 638 5724242 SGTC_1742 st038235 28.8875 µM -0.157307234879605 0.438173088338621 no 1908 0.437501359319958 611 564103 YBR002C RER2 SGTC_2203 7227154 166.4 µM -0.157714047934738 0.438007391664987 no 1909 0.437341065193995 612 896304 SGTC_2243 6634756 200 µM -0.157921596904052 0.437922860279241 no 1910 0.437259289869544 607 885676 SGTC_1618 st003135 44.5 µM -0.158087304899658 0.437855372088389 no 1911 0.437194002020552 615 1270615 SGTC_1669 st015249 58.4 µM -0.158175885016915 0.43781929664736 no 1912 0.437159102744411 622 722793 SGTC_418 lividomycin a 100 µM -0.158914865139731 0.437518357247795 no 1913 0.436867974419277 609 72394 An antibiotic. SGTC_1132 3456-3614 2.5 µM -0.159321293576283 0.437352860300824 no 1914 0.436707872590261 649 3125502 SGTC_1803 st050068 52.4 µM -0.159322930611792 0.437352193724977 no 1915 0.436707227743978 620 3984059 YIL048W | YNL267W NEO1 | PIK1 SGTC_141 0443-0274 32.331 µM -0.159731699663585 0.437185754783408 no 1916 0.436546214389455 629 1627241 SGTC_2022 5136654 200 µM -0.160591141065242 0.436835851378913 no 1917 0.43620771636987 637 1713771 SGTC_1033 k072-0102 21.3 µM -0.16067415891262 0.436802055029257 no 1918 0.43617502158256 615 5965931 SGTC_680 0417-1641 114 µM -0.161537949020915 0.436450435736511 no 1919 0.435834862409105 614 2835990 SGTC_1018 4259-0013 28.1 µM -0.161807323496264 0.436340792894768 no 1920 0.4357287928649 634 6801262 SGTC_1808 st050063 61.5 µM -0.162884601123732 0.435902360161989 no 1921 0.435304647712831 630 4011993 SGTC_1154 4088-0362 150 µM -0.164880117047419 0.435090429317964 no 1922 0.434519171247565 615 6618304 SGTC_874 0599-0792 117 µM -0.165296280511074 0.434921136070017 no 1923 0.434355393136953 632 765305 SGTC_458 nppb 133 µM -0.166721405036487 0.434341492992984 no 1924 0.433794631238663 630 4549 A chloride channel blocker. SGTC_919 tnp00227 403.569 nM -0.167676742929691 0.433953005885477 no 1925 0.433418796787326 655 1269246 A methoxyflavone. YNL221C POP1 SGTC_3131 9127911 49.47 µM -0.167852874908106 0.433881388962491 no 1926 0.433349512195496 660 45595681 SGTC_2890 9046729 58.44 µM -0.167913705984266 0.433856654977544 no 1927 0.433325583704365 628 903329 SGTC_721 1187-1332 279 µM -0.16792920665101 0.433850352430168 no 1928 0.433319486406514 637 25730 SGTC_2093 5331342 194.4 µM -0.168064360891403 0.433795399635643 no 1929 0.433266323194478 613 33839 SGTC_2149 5554786 194.827 µM -0.171396256231493 0.432441080874736 no 1930 0.43195609915904 623 745063 YPR165W RHO1 SGTC_3061 glucosamine 200 µM -0.17152639216995 0.432388200388124 no 1931 0.431904939999024 612 91431 and experimental redox chemotherapeutic SGTC_92 0063-0024 660.874 µM -0.1716349791499 0.432344077205917 no 1932 0.431862253059358 605 3594437 SGTC_2682 pyrogallin 40.03 µM -0.173387306413833 0.431632154421594 no 1933 0.431173501004446 635 822798 An ATP competetive kinase inhibitor. SGTC_1235 benzylparaben 21.5 µM -0.173737238390322 0.43149001312146 no 1934 0.431035985274062 652 7180 SGTC_2782 7736369 71.43 µM -0.174473525585981 0.431190964501954 no 1935 0.430746667584272 622 2950836 YOL077C BRX1 SGTC_917 harmaline 728.087 nM -0.175063871852958 0.430951219376853 no 1936 0.430514722958394 622 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7 SGTC_1547 harmine 94.2 µM -0.175311158234205 0.430850801626638 no 1937 0.430417572272607 597 5280953 A monoamine oxidase inhibitor YHR072W ERG7 SGTC_225 nsc-122657 1.016 µM -0.177138491366193 0.430108899423132 no 1938 0.429699804115774 659 275685 SGTC_2371 9071574 200 µM -0.178091512587018 0.429722067935433 no 1939 0.429325553729107 632 45596039 SGTC_654 1124-0271 80.9 µM -0.179394335103467 0.429193361253928 no 1940 0.428814039584452 628 5403748 SGTC_731 3966-0296 387 µM -0.179791305284995 0.429032289463344 no 1941 0.428658204883174 638 660956 SGTC_1036 k216-0215 33.5 µM -0.180459664968805 0.42876112731307 no 1942 0.428395858597788 617 622330 SGTC_1723 st034307 2.5525 µM -0.181567325842078 0.428311809094711 no 1943 0.427961146388633 615 867466 SGTC_2871 9038510 12.99 µM -0.182281737871394 0.428022059957191 no 1944 0.427680814828387 633 4945164 SGTC_2630 antimycin a 100 µM -0.183596524216906 0.427488914299532 no 1945 0.427164995022622 647 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain. SGTC_516 3992-2719 87.3 µM -0.183785318887309 0.42741236893742 no 1946 0.427090936893571 626 5350887 YDR037W KRS1 SGTC_1990 st072050 59.8 µM -0.184003642294902 0.427323854780683 no 1947 0.427005298786564 624 17233948 SGTC_2369 9071472 200 µM -0.184127385239893 0.42727368770072 no 1948 0.426956761718347 623 17296037 SGTC_2102 5377816 72.7585 µM -0.184463034323419 0.427137616901649 no 1949 0.4268251119245 635 1379702 SGTC_3235 9132602 49.47 µM -0.186045748515215 0.42649610795774 no 1950 0.426204442714839 639 4912240 SGTC_1336 1486-0901 104 µM -0.186420446441957 0.426344263027805 no 1951 0.426057529762486 623 5006114 SGTC_593 1203-0218 61.7 µM -0.186503131480336 0.42631075669569 no 1952 0.426025111687461 645 3666956 SGTC_2779 methotrexate 400 µM -0.186595919347919 0.426273157042838 no 1953 0.425988733221768 636 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2 SGTC_3348 9149464 3.537 µM -0.186675027010921 0.42624110143427 no 1954 0.42595771872248 629 1951442 SGTC_1401 3807-4679 7.6 µM -0.186853886182368 0.426168626818856 no 1955 0.425887597904257 612 3291456 SGTC_1776 st049249 45.9 µM -0.187466497982244 0.425920412417083 no 1956 0.425647444371381 620 1822314 SGTC_504 lovastatin 124 µM -0.190487623614409 0.424696761796058 no 1957 0.424463520279112 671 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1 SGTC_321 4534-3890 65.3 µM -0.190736145504857 0.424596134764162 no 1958 0.424366159256597 640 699746 SGTC_2807 7945238 51.95 µM -0.190813405753074 0.424564852929492 no 1959 0.424335892694892 663 17148797 SGTC_873 0591-4978 488 µM -0.191348618002797 0.424348164363719 no 1960 0.424126236530713 623 3305145 SGTC_2865 9030313 51.95 µM -0.191441265316225 0.424310657053422 no 1961 0.424089946414996 623 42562754 SGTC_190 3970-0790 3.722 µM -0.192467572017663 0.423895213287535 no 1962 0.423687983398573 624 2832352 SGTC_1105 epirubicin 18.1 µM -0.194461348688781 0.423088384683925 no 1963 0.422907328639347 639 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_2999 9069765 71.4286 µM -0.195035962678765 0.422855913334198 no 1964 0.422682397023214 639 2097066 SGTC_1191 1487-1166 10.6 µM -0.195183314784103 0.422796303476652 no 1965 0.422624720363685 632 3955771 SGTC_2072 5231554 129 µM -0.196386599732544 0.422309592559074 no 1966 0.422153791953627 642 789545 SGTC_1198 1612-1005 86.7 µM -0.197043389771004 0.422043980718755 no 1967 0.421896791603776 631 6998509 SGTC_3093 9117344 49.47 µM -0.197185928913081 0.421986341276652 no 1968 0.421841020771439 630 24824913 SGTC_1827 berberine 7.24 µM -0.198432637001985 0.421482273506363 no 1969 0.421353292233706 650 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_271 rotenone 740 µM -0.198447377116284 0.421476314565927 no 1970 0.421347526428072 643 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria. SGTC_519 k048-0011 62.8 µM -0.199697994609929 0.42097079692423 no 1971 0.420858391127095 632 6836379 SGTC_637 1181-0519 7.26 µM -0.20118012588682 0.420371866805789 no 1972 0.420278865518101 655 6252091 YGR060W ERG25 SGTC_3165 9101544 49.47 µM -0.201408760132089 0.420279491948097 no 1973 0.420189482985101 655 5002184 SGTC_1892 st058411 7.36 µM -0.201562490973789 0.420217382703521 no 1974 0.420129385588111 640 3934738 SGTC_2300 7976697 71.57 µM -0.201896035784355 0.420082633127427 no 1975 0.419999000624209 614 2236109 SGTC_2162 5663267 200 µM -0.202124226967286 0.419990451014106 no 1976 0.419909804176282 685 6456493 SGTC_2010 4012422 159 µM -0.203259093441515 0.419532065684179 no 1977 0.419466263399828 651 952393 SGTC_2288 7946289 167.31 µM -0.203453601811832 0.419453512508245 no 1978 0.419390253791292 671 1246052 SGTC_3289 9119912 71.43 µM -0.203528863660231 0.419423118496355 no 1979 0.419360843917221 694 17014829 SGTC_2956 9076196 2.52 µM -0.204617105296307 0.41898369295404 no 1980 0.418935645032825 662 16423868 SGTC_2828 7998861 71.43 µM -0.204898786691968 0.418869968111975 no 1981 0.418825601594136 622 2988188 SGTC_1507 4075-3230 155 µM -0.205990719932669 0.418429179814586 no 1982 0.418399080141289 619 659771 SGTC_3099 9120367 49.47 µM -0.206251714156299 0.418323837602514 no 1983 0.418297147036634 643 24824940 SGTC_85 0868-0259 160.055 µM -0.206576811661122 0.418192630285831 no 1984 0.41817018562552 657 83173 SGTC_462 ag-879 158 µM -0.208514657968436 0.417410716997544 no 1985 0.4174135693786 663 6809654 Ag-879 is a 5-Lipoxygenase inhibitor. SGTC_2949 9072542 2.23 µM -0.208724110040444 0.417326223414154 no 1986 0.417331808785441 675 16457352 SGTC_606 k015-0008 38.6 µM -0.210409309808707 0.416646548102005 no 1987 0.416674113558357 663 1970475 SGTC_2689 tacrolimus 100 µM -0.212829347462402 0.415670933942991 no 1988 0.415730036075588 636 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). SGTC_1281 0884-0031 11.8 µM -0.213461186389552 0.415416299642263 no 1989 0.415483630096272 629 1548255 SGTC_1195 1502-0147 41.1 µM -0.214260951570601 0.415094041151912 no 1990 0.415171783520095 643 817940 SGTC_1950 st077106 7.18 µM -0.21492575885687 0.414826206245524 no 1991 0.414912600747439 616 13831864 SGTC_3190 9110366 49.47 µM -0.216738854855032 0.414095954919636 no 1992 0.414205932933064 672 17123768 SGTC_1882 5615643 20 µM -0.21759631595627 0.413750702986718 no 1993 0.413871827579673 627 2253075 SGTC_1379 2144-0755 36.5 µM -0.217651861306523 0.413728340257191 no 1994 0.413850186763841 643 5392327 SGTC_757 1066-0008 322 µM -0.218026884528485 0.413577362075236 no 1995 0.413704082220711 648 6842497 SGTC_249 wiskostatin 11.211 µM -0.21843545917795 0.413412891182593 no 1996 0.413544920041722 643 2775510 A n-wasp and actin depolymerizer. SGTC_693 4161-2696 114 µM -0.21893952413774 0.41321000179605 no 1997 0.413348578737002 636 805759 SGTC_817 1391-0715 46 µM -0.220532148209917 0.412569112908513 no 1998 0.412728368977816 661 1353946 SGTC_2196 6573537 42.6665 µM -0.220548358387313 0.412562590955585 no 1999 0.412722057424937 661 2903087 SGTC_1382 3002-2117 298 µM -0.22107687874156 0.412349960936402 no 2000 0.412516286472817 654 1497314 SGTC_1897 st060201 15 µM -0.222249612344216 0.411878248221738 no 2001 0.412059787326376 638 611878 SGTC_968 1309-0633 340 µM -0.222266043934229 0.411871639788981 no 2002 0.412053391997261 670 3761976 SGTC_326 k292-0812 17.5 µM -0.222322308596979 0.41184901153882 no 2003 0.412031493439161 675 3579357 SGTC_1847 st056231 15 µM -0.222432098657116 0.411804857547136 no 2004 0.411988763250964 641 5393180 SGTC_3006 9075424 71.4286 µM -0.223577421455616 0.411344312651929 no 2005 0.411543067008313 643 7465181 SGTC_1796 st049173 110.4 µM -0.224475043835905 0.410983455726301 no 2006 0.411193841794318 655 94134 SGTC_1751 st044839 27.194 µM -0.224591554581851 0.410936622270289 no 2007 0.411148517763491 621 5291326 SGTC_1600 coumarin 106 71.1 µM -0.224805038767829 0.410850812002017 no 2008 0.411065473018211 689 100336 A hepatotoxic, DNA x-linker. SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM -0.226251833066305 0.410269383631037 no 2009 0.410502779332143 653 551469 SGTC_2309 7664088 163.95 µM -0.22784041659303 0.409631201072674 no 2010 0.409885152508316 669 704922 SGTC_221 trifluoperazine 10.304 µM -0.228472922819015 0.409377170518606 no 2011 0.409639301970351 655 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1 SGTC_1410 3909-8106 77.9 µM -0.228595418455217 0.409327977556509 no 2012 0.409591692917022 654 1039210 SGTC_2675 theaflavin digallate 100 µM -0.228613599189962 0.409320676485875 no 2013 0.409584626921191 654 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative. SGTC_1559 coumarin 343 70.1 µM -0.228629940886893 0.409314113968064 no 2014 0.409578275697857 670 108770 A hepatotoxic, DNA x-linker. SGTC_1158 4092-0494 91.8 µM -0.229371950990225 0.409016163483366 no 2015 0.409289917460214 681 1148199 SGTC_3171 9103192 49.47 µM -0.230291844291291 0.408646857872372 no 2016 0.408932498815491 638 13018434 SGTC_991 3996-0057 64.7 µM -0.230423753085918 0.40859390765646 no 2017 0.408881252698846 635 715343 SGTC_2081 5214970 32.255 µM -0.231315979279018 0.408235798219045 no 2018 0.408534666808403 657 2063512 SGTC_82 0054-0107 293.755 µM -0.232788920314066 0.407644777272595 no 2019 0.407962658454109 641 3104697 SGTC_1163 k060-0048 49.9 µM -0.233125359583756 0.407509809681466 no 2020 0.407832031627765 638 6809982 SGTC_2139 5578692 56.4705 µM -0.23334654019264 0.407421085787578 no 2021 0.407746161023363 647 650991 YMR113W FOL3 SGTC_440 fluspirilene 35.1 µM -0.234485632558377 0.406964228133963 no 2022 0.40730399293428 668 3396 An atypical antipsychotic. SGTC_2803 7707263 71.43 µM -0.235238469323916 0.406662356076699 no 2023 0.407011824700786 650 2199229 SGTC_341 1486-1430 230 µM -0.23572966801658 0.406465425388501 no 2024 0.406821223403159 655 2054753 YPL210C SRP72 SGTC_3263 9137018 49.47 µM -0.235733792295255 0.406463771988577 no 2025 0.406819623140335 639 43844957 SGTC_314 1671-0008 2.74 µM -0.236091133982505 0.406320522068432 no 2026 0.406680976776278 675 3913060 SGTC_2934 9036370 36.88 µM -0.236531827956982 0.40614387543469 no 2027 0.406510006349236 654 6462800 SGTC_1936 st074407 74.3 µM -0.23658713786874 0.406121706501181 no 2028 0.40648854972541 638 809813 SGTC_1615 st002656 86.5 µM -0.237343097221311 0.405818738338976 no 2029 0.406195315170007 635 1584458 SGTC_3124 9127567 49.47 µM -0.238025901906933 0.405545137071514 no 2030 0.405930502322394 672 17592030 SGTC_2365 9042475 200 µM -0.238214963412475 0.405469387881685 no 2031 0.405857186005865 644 6464479 SGTC_435 c-PAF 6.7 µM -0.238597869121576 0.405315984119912 no 2032 0.405708708804557 666 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase SGTC_800 3448-7362 155 µM -0.239318242664863 0.405027419840253 no 2033 0.405429410372874 656 15991913 SGTC_1259 0671-0132 43 µM -0.241180136569498 0.40428182955412 no 2034 0.404707752640871 653 X1259 SGTC_1443 4112-3303 14 µM -0.24553268602363 0.402540223307765 no 2035 0.403022001395234 643 704433 SGTC_3013 9080133 71.4286 µM -0.245825085708952 0.402423292926324 no 2036 0.402908818612563 651 17050193 SGTC_2806 7952793 58.44 µM -0.246202087523259 0.402272543112088 no 2037 0.402762899839391 646 2972490 SGTC_2445 5742597 35.57 µM -0.246607263004872 0.40211054383983 no 2038 0.402606091531648 652 1774255 SGTC_2351 9026858 72.31 µM -0.246759409671405 0.402049716145286 no 2039 0.402547212790237 672 1409300 SGTC_2501 sodium tetradecyl sulfate 13.37 µM -0.247442102884396 0.401776807058111 no 2040 0.402283046804445 649 23665772 A membrane-active detergent. SGTC_449 xestospongin c 11.1929 µM -0.248285878153733 0.401439571022187 no 2041 0.401956612293149 682 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1 SGTC_1923 st058458 19.1 µM -0.251837416924055 0.400020916567481 no 2042 0.400583367328744 703 3534982 SGTC_354 2783-3500 4.88 µM -0.252216047646078 0.399869750793661 no 2043 0.400437037363706 655 6740761 SGTC_1445 4239-0156 97.7 µM -0.252338509975543 0.399820861741033 no 2044 0.400389712159047 699 4008346 SGTC_2396 5342950 42.78 µM -0.252361711758761 0.399811599369989 no 2045 0.400380746063376 638 1886677 SGTC_2234 tolnaftate 200 µM -0.252456490815062 0.399773763260899 no 2046 0.400344120196025 664 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7 SGTC_597 k018-0003 82.8 µM -0.253004532859061 0.399555001548897 no 2047 0.400132355209445 691 6786234 SGTC_950 1165-0508 94.1 µM -0.253981992070569 0.399164907875644 no 2048 0.39975473514255 662 6148369 SGTC_2989 9073649 71.4286 µM -0.255272812422351 0.398649909386711 no 2049 0.399256198510262 692 21367202 SGTC_867 0518-0118 155 µM -0.255961579726113 0.398375184080557 no 2050 0.398990252091188 669 6848158 SGTC_938 3126-1755 342 µM -0.257451156639034 0.39778121608932 no 2051 0.398415258032366 673 1777771 SGTC_250 brefeldin a 552.239 µM -0.261688748870737 0.396092778214136 no 2052 0.396780707722195 645 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.  SGTC_2744 captopril 92.04 µM -0.261775667204044 0.396058166509534 no 2053 0.396747199911312 655 44093 angiotensin-converting enzyme (ACE) inhibitor  SGTC_166 k072-0058 166.424 µM -0.262382494909512 0.395816544806999 no 2054 0.396513283546791 661 5846229 SGTC_2262 9014885 67.46 µM -0.262513949868102 0.3957642084163 no 2055 0.396462615969537 662 6457424 SGTC_856 0433-0016 11.3 µM -0.266462177726684 0.394193173527126 no 2056 0.394941642257767 663 3911780 SGTC_2980 9014342 25.29 µM -0.266543985921172 0.394160639421324 no 2057 0.394910144166921 699 2996599 SGTC_1697 st025554 27.742 µM -0.267004023782473 0.393977701820055 no 2058 0.394733031499876 646 1269519 SGTC_386 1509-0011 3.07 µM -0.269863911908413 0.392840971455781 no 2059 0.393632475771024 683 3107280 SGTC_66 0109-0187 42.4 µM -0.269908741559555 0.392823160093084 no 2060 0.393615230948957 659 759417 SGTC_2856 9022925 19.48 µM -0.271705728466821 0.392109380631212 no 2061 0.392924148134588 668 4944862 SGTC_630 4356-0227 183 µM -0.271844695724259 0.392054196665903 no 2062 0.392870718319214 687 779312 SGTC_3091 9116372 49.47 µM -0.272711459745881 0.391710053297605 no 2063 0.392537512450383 666 17169793 SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM -0.272852985908073 0.391653869237275 no 2064 0.39248311371063 658 2333 A French combination drug. SGTC_248 streptozotocin 5.23457 mM -0.273916063382422 0.391231913513501 no 2065 0.392074563372898 681 5300 DNA alkylating agent. SGTC_2711 st079103 59.1 µM -0.27395376993799 0.391216949409814 no 2066 0.392060074582644 673 54693780 SGTC_727 3032-0951 202 µM -0.281197597896799 0.388345198520698 no 2067 0.389279423482428 684 3652836 SGTC_3026 9090633 49.47 µM -0.28125140177325 0.38832389106027 no 2068 0.389258791067596 664 25236842 SGTC_1581 himbacine 57.9 µM -0.281412495615688 0.388260096539144 no 2069 0.389197017553347 704 5281825 An alkaloid muscarinic receptor antagonist. SGTC_3083 9117465 49.47 µM -0.281550628967014 0.38820539696694 no 2070 0.389144050765981 713 16420915 SGTC_220 paclitaxel 373.376 µM -0.282483466410477 0.387836059783881 no 2071 0.388786411235318 679 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_525 k781-2675 26.7 µM -0.282617632516314 0.387782947899617 no 2072 0.388734981182453 645 3651118 YDL195W SEC31 SGTC_347 4534-1311 26.2 µM -0.282914551249242 0.387665415146935 no 2073 0.388621169905996 677 2862016 SGTC_2402 5553605 200 µM -0.283326989363369 0.38750217211112 no 2074 0.388463095010452 686 6758546 SGTC_1635 st007035 42.4 µM -0.283517562015119 0.387426750157337 no 2075 0.388390060588171 687 3716403 SGTC_1899 st063254 59.6 µM -0.285554372425077 0.386620918126468 no 2076 0.387609727169378 688 3093813 SGTC_2213 7173844 200 µM -0.285591087561799 0.386606396832737 no 2077 0.387595665189548 660 892728 SGTC_2844 9010103 25.97 µM -0.285926844320534 0.386473608221579 no 2078 0.38746707643862 729 2480525 SGTC_1656 st012921 11 µM -0.286198153601022 0.386366317686228 no 2079 0.387363178920161 675 6732821 SGTC_2391 6285546 200 µM -0.288452099574138 0.385475320718126 no 2080 0.38650034594429 661 846083 SGTC_88 0180-0332 8.668 µM -0.288525437562731 0.385446339938966 no 2081 0.386472280830069 653 3101745 SGTC_2643 anethole 100 µM -0.288836176783262 0.385323553040629 no 2082 0.386353373173087 705 637563 An anti-fungal, anti-helmenthic and channel blocker. SGTC_1875 nocodazole 6 µM -0.289671837674477 0.384993403276945 no 2083 0.386033651643127 668 4122 A microtubule depolymerizer. YJL014W CCT3 SGTC_691 1548-0686 185 µM -0.289991587024854 0.38486709994224 no 2084 0.385911336890624 651 46495133 SGTC_1188 1403-0014 4.57 µM -0.290758370292567 0.384564264735249 no 2085 0.385618063038834 682 9614867 SGTC_780 0109-0199 192 µM -0.291452666970838 0.384290118304701 no 2086 0.38535256974111 677 610414 SGTC_2922 7999257 32.47 µM -0.291500428723408 0.384271261469632 no 2087 0.385334308016073 662 2988377 SGTC_1065 prochlorperazine maleate 2.48 µM -0.291666948430317 0.384205519905429 no 2088 0.38527064112881 682 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine. SGTC_3305 9127027 53.8275 µM -0.291890500305859 0.384117267421738 no 2089 0.385185173512691 681 41905295 SGTC_2700 st077718 96.8 µM -0.292793819211954 0.383760721772153 no 2090 0.384839876442175 662 904970 SGTC_1454 4239-0054 42.6 µM -0.293044081509204 0.383661959062083 no 2091 0.384744228874559 710 1340767 SGTC_200 k038-0079 37.545 µM -0.293759699610228 0.38337959155234 no 2092 0.38447076603058 679 3436683 SGTC_219 mitoxanthrone 164.414 µM -0.294073424603906 0.383255821936996 no 2093 0.38435089879308 687 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA.  YMR168C CEP3 SGTC_1446 4239-0190 62 µM -0.295033376109651 0.382877179504038 no 2094 0.383984191725911 693 1340085 SGTC_2601 securinine 100 µM -0.295038916482233 0.38287499448876 no 2095 0.38398207557241 664 442872 A GABA receptor antagonist. SGTC_871 0574-0004 149 µM -0.297523281282707 0.381895585841232 no 2096 0.383033518195517 682 9551173 SGTC_2378 9074213 121.43 µM -0.299080276512516 0.381282157833114 no 2097 0.38243939748965 653 657714 SGTC_642 0335-0876 158 µM -0.299873174228792 0.380969884925298 no 2098 0.382136948534935 657 6812350 SGTC_796 1234-0020 70.7 µM -0.299994474766858 0.380922119047143 no 2099 0.382090685069392 639 46495034 SGTC_1118 chelidonine 707.474 nM -0.300421113621057 0.380754131083236 no 2100 0.381927980356479 679 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor. SGTC_2983 9022671 12.99 µM -0.302995248926887 0.379741049847396 no 2101 0.380946741163359 722 6405161 SGTC_374 0880-0231 82.3 µM -0.303178792247863 0.379668845637724 no 2102 0.380876805108975 692 6833587 SGTC_2849 9019321 12.99 µM -0.303199652757158 0.379660639575782 no 2103 0.38086885681367 655 16489627 SGTC_2337 9009472 200 µM -0.303847663225379 0.379405753631135 no 2104 0.38062197616988 693 5742383 SGTC_694 1315-0438 43.2 µM -0.304872667790368 0.379002689322057 no 2105 0.380231566658616 707 6793154 SGTC_1200 1643-0193 18.4 µM -0.305652287409478 0.37869620619821 no 2106 0.379934702401778 698 5403974 SGTC_2383 9036125 200 µM -0.306306395520626 0.378439122838304 no 2107 0.379685685090489 686 79580 SGTC_2977 9011197 71.43 µM -0.306368926461697 0.378414549189752 no 2108 0.379661882329622 692 2704722 SGTC_1085 doxorubicin 7.67 µM -0.308051295445781 0.377753590266019 no 2109 0.379021650386032 700 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_636 0kpi-0074 126 µM -0.308206746104661 0.377692535780657 no 2110 0.378962509760342 679 616434 SGTC_2524 avocatin b 10.57 µM -0.308920309510733 0.377412317292523 no 2111 0.378691073587348 694 6710748 SGTC_3116 9124943 49.47 µM -0.308990018573978 0.377384945791777 no 2112 0.378664559792404 654 41905195 YPL160W CDC60 SGTC_841 0251-0215 91.2 µM -0.309791751622419 0.377070186892591 no 2113 0.378359662254815 705 3888614 SGTC_193 1273-0060 1.558 µM -0.311527811313224 0.376388893230708 no 2114 0.377699701822518 709 2847393 YHR072W ERG7 SGTC_2451 5856223 45.7 µM -0.311782606997495 0.376288934377443 no 2115 0.377602871618993 663 2179896 SGTC_154 3389-1638 511.116 µM -0.312132939523829 0.376151509029263 no 2116 0.377469747034574 733 5238686 SGTC_933 2914-0560 114 µM -0.312283862584929 0.376092311102496 no 2117 0.377412401521615 685 463887 SGTC_359 0081-0058 15.9 µM -0.31414693390214 0.375361782199815 no 2118 0.376704722207993 726 3494159 SGTC_652 0437-0092 114 µM -0.315176507879146 0.374958267422704 no 2119 0.376313820630314 675 3091274 SGTC_959 1222-0044 107 µM -0.315773814165567 0.374724231428828 no 2120 0.376087097589237 695 6083612 SGTC_2644 guaiazulene 100 µM -0.315774193445032 0.374724082834548 no 2121 0.376086953637489 683 3515 A coloring agent. SGTC_2001 4023502 57.655 µM -0.316486679895659 0.374444977431531 no 2122 0.375816566948306 668 108941 YCR052W RSC6 SGTC_2398 5228213 48.84 µM -0.316570094104362 0.374412305520791 no 2123 0.375784915464803 692 80771 YMR134W ERG29 SGTC_2284 7945075 39.21 µM -0.317052188321621 0.374223495181978 no 2124 0.375602001413971 689 1245402 SGTC_838 0109-0203 71.4 µM -0.319738544775994 0.373171947556546 no 2125 0.374583268932401 679 759422 SGTC_2658 polymyxin b sulfate 77.05 µM -0.319896555006827 0.373110125337146 no 2126 0.37452337473576 681 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides.  YIL048W NEO1 SGTC_1340 1486-1359 257 µM -0.32010480974093 0.373028649718601 no 2127 0.374444439851684 682 4309068 SGTC_1722 st034304 3.6505 µM -0.320458351894764 0.372890346224043 no 2128 0.374310448662973 689 4036148 YLR033W RSC58 SGTC_1352 1496-0991 99 µM -0.320840341584725 0.372740932642237 no 2129 0.374165693023155 716 3000039 SGTC_194 1486-1323 56.904 µM -0.323350959726312 0.371759392808565 no 2130 0.373214732357477 669 5178754 SGTC_150 3970-0969 77.2 µM -0.324480497227709 0.371318065277667 no 2131 0.372787142586569 700 6615640 SGTC_2550 chrysin dimethyl ether 71.87 µM -0.324634895173626 0.371257752772328 no 2132 0.372728706948146 678 88881 An O-methylated flavonoid and antioxidant. SGTC_1561 5-methoxyflavone 52.9 µM -0.325036896246364 0.371100733835225 no 2133 0.372576573659083 677 94525 SGTC_2692 st077426 47.7 µM -0.326034222388525 0.370711277593352 no 2134 0.372199231420783 730 25238571 SGTC_1218 1348-1416 30.7 µM -0.326113856465296 0.370680186160039 no 2135 0.372169106841429 690 6787668 SGTC_410 α-linolenic acid 100 µM -0.326215030582608 0.370640686093603 no 2136 0.372130835061404 700 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_1155 4088-0394 48.2 µM -0.327189212775436 0.370260418912078 no 2137 0.371762389623322 687 2326248 SGTC_2976 9009005 19.48 µM -0.327434945549301 0.370164518350434 no 2138 0.371669469565855 679 2993148 SGTC_2585 alliin 100 µM -0.327585927114773 0.370105599740772 no 2139 0.371612381923656 732 87310 A garlic compound which reacts with lipids. SGTC_2414 st077232 92.9 µM -0.329199496603726 0.369476115662619 no 2140 0.371002451701211 658 729801 SGTC_3226 9131256 49.47 µM -0.330552542571855 0.368948536251852 no 2141 0.370491249143077 674 17178073 SGTC_2425 5628681 7.85 µM -0.33076483012087 0.368865783509455 no 2142 0.370411064212384 700 5714958 SGTC_3331 9141060 1.957 µM -0.331500150816849 0.368579191935873 no 2143 0.370133363541901 694 4906567 YPR165W RHO1 SGTC_3107 9121808 49.47 µM -0.332369436491667 0.368240481729627 no 2144 0.369805157070564 670 662681 SGTC_2024 5144227 134 µM -0.332924727038702 0.368024170784274 no 2145 0.369595551841534 691 3475211 SGTC_823 0417-1665 178 µM -0.333050483063887 0.367975188896267 no 2146 0.369548088160181 723 3429856 SGTC_1498 4478-3555 97.6 µM -0.333524182044581 0.367790702736787 no 2147 0.36936931937042 689 3437919 SGTC_1506 4226-2149 212 µM -0.334121941158413 0.367557943815118 no 2148 0.369143771958681 703 991114 SGTC_3010 9080089 71.4286 µM -0.335761611953214 0.366919729201864 no 2149 0.36852532023415 706 17027233 SGTC_1245 0418-0076 17.2 µM -0.33661056999027 0.366589430730091 no 2150 0.368205243533998 728 6790114 SGTC_3284 9108171 64.8615 µM -0.337289271680135 0.366325443800928 no 2151 0.367949423163929 713 8687505 SGTC_2466 5983409 37.09 µM -0.338494115137024 0.365856965311338 no 2152 0.367495430544489 701 2879657 SGTC_3219 9131112 49.47 µM -0.339099723642466 0.365621562422496 no 2153 0.367267303309009 698 17612988 YMR079W SEC14 SGTC_2698 st077697 67.5 µM -0.339257304827649 0.365560318163313 no 2154 0.367207951581929 684 3154499 SGTC_1084 voriconazole 435 nM -0.339777665473151 0.365358103255494 no 2155 0.367011984339328 709 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_2350 9023895 38.85 µM -0.340419803354566 0.365108616657399 no 2156 0.366770203685447 675 2997209 SGTC_2479 5617353 43.85 µM -0.340446595879981 0.365098208332309 no 2157 0.366760116790702 714 2731746 SGTC_2230 bromochlorosalicylanilide 954.5 nM -0.34121056715365 0.364801463622619 no 2158 0.366472534349004 698 77254 SGTC_664 1222-0054 14.9 µM -0.341898809708968 0.364534203081581 no 2159 0.366213522716483 688 6813991 SGTC_2605 digitonin 300 nM -0.343246813914084 0.364010932647473 no 2160 0.365706394560262 702 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_579 4491-1009 110 µM -0.343748400299378 0.363816290688597 no 2161 0.365517754265208 714 1271041 SGTC_1160 4092-0570 10.5 µM -0.344101769101229 0.363679186058635 no 2162 0.36538487625295 682 4994975 SGTC_561 1550-0330 72.9 µM -0.346375477181684 0.362797421358611 no 2163 0.364530276087365 713 6812934 SGTC_920 mycophenolic acid 780.421 nM -0.347369935574931 0.362411989580767 no 2164 0.364156708347251 690 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_1287 0971-0001 34.6 µM -0.347627296506731 0.362312264429834 no 2165 0.364060051860062 677 4665869 SGTC_2020 4017018 200 µM -0.348398507978634 0.362013482581359 no 2166 0.363770461441893 725 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope. SGTC_3148 9097893 49.47 µM -0.34840113748563 0.362012464004537 no 2167 0.363769474193273 687 17174100 SGTC_795 0685-0265 78 µM -0.348794556902471 0.361860078429993 no 2168 0.363621775034676 684 302754 SGTC_2746 daunorubicin 9.88 µM -0.34963039782588 0.361536399712511 no 2169 0.363308047440147 701 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_3049 9092223 49.47 µM -0.349860003483439 0.361447502442647 no 2170 0.363221882452682 720 8623917 SGTC_2751 anetholtrithion 17.25 µM -0.35005384186172 0.361372459144551 no 2171 0.363149145375884 712 2194 A chloretic substance that stimulates the liver to produce bile. SGTC_3307 9126885 69.2785 µM -0.350195230305626 0.361317724869398 no 2172 0.363096093040069 702 24824909 SGTC_613 3914-0030 117 µM -0.351496188979579 0.360814231276342 no 2173 0.362608065537424 677 1145395 SGTC_1949 st076024 69.1 µM -0.351601738684012 0.360773392272374 no 2174 0.362568480543567 689 2921930 SGTC_2407 paclitaxel 400 µM -0.352048001317637 0.360600743101185 no 2175 0.362401131998564 764 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_1999 st074831 12.5 µM -0.352369974516481 0.360476196413259 no 2176 0.362280408332044 746 17112523 SGTC_889 0919-1524 82.7 µM -0.353813503368377 0.359917988142051 no 2177 0.36173932652111 701 3905452 SGTC_180 1486-1293 102.781 µM -0.355205074985235 0.359380154238065 no 2178 0.361217981513545 719 4140536 SGTC_1442 4112-3290 3 µM -0.357995503562398 0.358302510697277 no 2179 0.36017333924884 713 704353 SGTC_531 3788-1495 174 µM -0.35882047637468 0.357984127691666 no 2180 0.359864696724072 674 2896655 SGTC_41 0478-0632 82.643 µM -0.358906041412127 0.357951111096016 no 2181 0.35983268997446 728 3750424 SGTC_3320 9137005 35.139 µM -0.36098569024287 0.357148973641389 no 2182 0.359055072190004 718 4908713 SGTC_1026 k007-1105 30.6 µM -0.362014525534206 0.356752376558401 no 2183 0.358670587903505 658 7066794 SGTC_2978 9011784 42.97 µM -0.362224388799641 0.356671497123873 no 2184 0.358592177829329 683 2994934 SGTC_235 0330-0087 5 mM -0.362542184472425 0.356549033768371 no 2185 0.358473452902543 700 46494818 YHR062C RPP1 SGTC_2587 piperic acid 92.2 µM -0.363966362981533 0.356000404815957 no 2186 0.357941563806577 692 5370536 SGTC_572 0960-0087 17.7 µM -0.365194231662435 0.355527638474951 no 2187 0.357483211928744 680 6796365 SGTC_1276 0871-0068 94.2 µM -0.365260372996092 0.355502178374236 no 2188 0.357458527815531 694 3414906 SGTC_1620 st003704 16.5 µM -0.365731103024649 0.355320996637152 no 2189 0.357282867407128 686 2834414 SGTC_1865 st057639 52.2 µM -0.367476705327452 0.354649408379993 no 2190 0.356631732351184 686 688818 SGTC_172 1112-0046 2.638 µM -0.369226508403805 0.353976657084041 no 2191 0.355979449403795 731 2802135 YIL048W NEO1 SGTC_953 1188-0045 9.7 µM -0.372568088853507 0.352693178334604 no 2192 0.354734963462515 710 6144426 SGTC_863 0466-0191 129 µM -0.373617282397848 0.352290534908544 no 2193 0.354344537073792 723 765160 YPR165W RHO1 SGTC_2831 7999036 19.48 µM -0.37369181244702 0.35226193919858 no 2194 0.354316808733793 745 2988270 SGTC_683 panaxydol 45 µM -0.374162206827431 0.352081477429013 no 2195 0.354141819893051 698 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis. SGTC_2510 benzyl isothiocyanate 8.31 µM -0.374467633185965 0.351964321707212 no 2196 0.354028216391301 693 2346 DNA damaging agent; causes G2/M arrest. SGTC_2921 7974240 10.71 µM -0.377106249681379 0.350952784912554 no 2197 0.353047323462164 735 2979074 YDR527W RBA50 SGTC_3264 9137442 49.47 µM -0.378319798835435 0.350487914051384 no 2198 0.35259651958615 720 17015726 SGTC_2430 5571206 200 µM -0.378896498790353 0.350267077638314 no 2199 0.352382362131858 727 1731771 SGTC_2455 5377712 9.75 µM -0.380162832406219 0.349782336651849 no 2200 0.351912273566587 684 2243908 SGTC_2048 5246248 200 µM -0.380653080946096 0.349594739648583 no 2201 0.35173034414139 691 677046 SGTC_1343 1487-0095 224 µM -0.381888199581931 0.34912227583269 no 2202 0.351272146754157 746 4560101 YGL055W OLE1 SGTC_1553 gossypol 38.6 µM -0.384343468237762 0.348183768870964 no 2203 0.350361947216398 697 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_802 4112-3352 742 µM -0.384424906875698 0.34815265548407 no 2204 0.350331771554784 686 704594 SGTC_2796 7949634 45.45 µM -0.385719652663451 0.347658139159749 no 2205 0.349852153182971 696 2971588 SGTC_2491 paeonol 100 µM -0.386135980086211 0.347499181715595 no 2206 0.349697982033495 709 11092 Increases levels of cortical cytochrome oxidase. SGTC_2200 6600604 21.907 µM -0.386556642233988 0.347338596468284 no 2207 0.349542230853069 742 2904777 SGTC_3260 9137109 49.47 µM -0.387623005233013 0.346931641622267 no 2208 0.349147520887084 735 17478346 SGTC_265 mycophenolic acid 32.932 µM -0.388795064096893 0.346484553798037 no 2209 0.348713876208898 732 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1 SGTC_2182 6325192 200 µM -0.390576617526981 0.345805380753855 no 2210 0.348055105982501 677 736248 SGTC_2322 7413319 38.22 µM -0.390943207728529 0.345665688781286 no 2211 0.347919607639085 721 1840400 SGTC_1107 amlodipine 47 µM -0.390990354406605 0.34564772470705 no 2212 0.34790218278632 720 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.  SGTC_641 4092-0595 30 µM -0.39136220587168 0.345506052097843 no 2213 0.347764762157163 704 786260 SGTC_2417 cerulenin 830 nM -0.394829374135881 0.344186130906194 no 2214 0.346484407530221 736 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1 SGTC_3075 9116269 49.47 µM -0.394902434378981 0.344158337840003 no 2215 0.346457446667806 736 17015205 YNL244C SUI1 SGTC_2837 9008476 45.46 µM -0.396279049288748 0.343634813135822 no 2216 0.345949590545606 754 2992805 SGTC_2805 7950783 58.44 µM -0.396509388950318 0.343547244536412 no 2217 0.345864641442901 697 1178958 YDL195W SEC31 SGTC_1932 st074806 40.9 µM -0.396586389831635 0.343517972859851 no 2218 0.34583624530292 724 17251235 SGTC_1199 1638-0010 4.46 µM -0.397169351340793 0.343296392077551 no 2219 0.345621290756253 718 3111136 SGTC_2888 9058547 12.99 µM -0.398508989584155 0.342787406402642 no 2220 0.345127516574887 705 16476514 SGTC_2967 9089538 49.85 µM -0.399375545946229 0.3424583165649 no 2221 0.344808254879977 726 728216 SGTC_3350 9150499 3.57 µM -0.399579400327889 0.342380916683975 no 2222 0.344733165715797 718 4910996 YPR165W RHO1 SGTC_1694 st024011 44.9 µM -0.40036691992672 0.342081971712494 no 2223 0.344443142655388 747 2787533 SGTC_3205 9113483 49.47 µM -0.400487082613254 0.342036366267491 no 2224 0.34439889788769 738 17018033 SGTC_1951 sophoraflavanone G 9.2 µM -0.401269697968798 0.34173939601177 no 2225 0.344110785386137 726 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity. SGTC_2792 7535235 81.82 µM -0.402647076325489 0.341216975622295 no 2226 0.343603936270075 705 1281891 SGTC_1094 duloxetine 25.4 µM -0.404472440694952 0.340525109176346 no 2227 0.342932669914201 704 60834 A selective serotonin reuptake inhibitor. SGTC_1425 4048-4433 7.33 µM -0.404669202385788 0.340450562725231 no 2228 0.342860341576684 748 23734946 SGTC_1204 4049-0315 18.3 µM -0.404985487016899 0.340330746077067 no 2229 0.342744089441283 712 588402 SGTC_3277 9138724 49.47 µM -0.405738179283937 0.340045671972156 no 2230 0.342467493206252 713 15943418 SGTC_320 4092-0846 5.34 µM -0.406792056315759 0.339646681017398 no 2231 0.342080360784574 710 1359356 SGTC_986 1493-0483 84 µM -0.407326272313427 0.339444498907455 no 2232 0.341884184606652 742 40079 SGTC_2760 etidronate 98.04 µM -0.409159388633858 0.338751079955269 no 2233 0.341211347707933 713 3305 A chelator and antioxidant. SGTC_2549 cedrol 20.94 µM -0.409166968136507 0.33874821396403 no 2234 0.341208566732344 726 6708665 A sedative which affects the nervous system. SGTC_2121 5257820 149.641 µM -0.409998185876954 0.338433967340476 no 2235 0.340903639159637 720 791256 SGTC_2043 5101342 149 µM -0.411285766253545 0.337947412334 no 2236 0.340431502700509 724 678451 SGTC_1647 st011722 22.4 µM -0.41269210088663 0.337416291292185 no 2237 0.339916106459239 731 2854783 SGTC_2971 9092186 9.93 µM -0.412777651513947 0.33738399239251 no 2238 0.339884763340012 682 25236400 SGTC_1739 st037196 92.5 µM -0.414370986403409 0.336782661774056 no 2239 0.339301216901952 734 612214 SGTC_3161 9100388 49.47 µM -0.415679056677258 0.336289302712114 no 2240 0.338822434231037 730 25236368 SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM -0.415959743658896 0.336183473941336 no 2241 0.338719730475799 732 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1 SGTC_1258 0671-0043 57.1 µM -0.416697017923031 0.335905557708006 no 2242 0.338450017930025 761 4298767 SGTC_2305 7443522 69.23 µM -0.417575099035302 0.335574681238556 no 2243 0.33812890297737 718 5415886 SGTC_804 1595-0054 20.9 µM -0.419579602222453 0.334819826967361 no 2244 0.337396296016747 750 761523 Stimulates phospholipase C. SGTC_468 gf-109203x 121 µM -0.420051566926329 0.33464219175216 no 2245 0.337223891578897 721 2396 A protein kinase C inhibitor. SGTC_1082 camptothecin 424.86 nM -0.421896976846245 0.333947983072155 no 2246 0.336550108382659 731 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_2380 9035439 200 µM -0.422574855715399 0.333693120205668 no 2247 0.336302737569309 718 6462575 SGTC_463 ikarugamyin 104 µM -0.424704905226252 0.332892782865308 no 2248 0.335525903759516 745 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis. SGTC_189 3970-0742 2.116 µM -0.425862296929939 0.332458227285389 no 2249 0.335104094773641 750 2891807 SGTC_740 k014-0057 261 µM -0.428214299465 0.331575835745555 no 2250 0.334247553238076 739 4012779 SGTC_3201 9113999 49.47 µM -0.42925000554596 0.331187569820816 no 2251 0.33387064774371 749 16649224 SGTC_3044 9093193 49.47 µM -0.432621136944454 0.329925056772642 no 2252 0.33264501558048 760 25236277 SGTC_875 0709-0210 25.7 µM -0.432820466962108 0.329850466689006 no 2253 0.332572601580505 762 6251364 SGTC_2027 5150920 200 µM -0.432991919653443 0.329786313823659 no 2254 0.332510320047836 733 786715 SGTC_1969 st069479 40.1 µM -0.434667468778461 0.329159633392335 no 2255 0.331901907310228 748 3895485 SGTC_3224 9130643 49.47 µM -0.435035765574862 0.329021949138857 no 2256 0.33176823349432 762 17644395 SGTC_2346 9031566 143.75 µM -0.435216416717127 0.328954422905089 no 2257 0.331702673747717 735 4771086 SGTC_7 0192-1582 4.227 µM -0.436612052006909 0.328432931703219 no 2258 0.331196360377335 755 252616 SGTC_1086 cerivastatin 2.18 µM -0.436853722821804 0.328342663216132 no 2259 0.331108717513761 715 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7 SGTC_1946 st076057 65.1 µM -0.438240099008161 0.327825020011788 no 2260 0.330606121690873 726 953009 SGTC_2229 7354935 190 µM -0.438326426975146 0.327792797921563 no 2261 0.330574835745413 750 318112 SGTC_1782 st039423 80.636 µM -0.439078579023664 0.327512109902764 no 2262 0.3303022999403 751 2068169 SGTC_797 k781-0471 270 µM -0.439169795668427 0.32747807630921 no 2263 0.330269254492193 703 23738129 SGTC_261 5-fluorouridine 15.376 µM -0.439912042883463 0.327201191794291 no 2264 0.330000406616976 726 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_2759 disulfiram 3.38 µM -0.440272851551899 0.32706663170213 no 2265 0.329869750528165 713 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_1376 2910-0861 41.3 µM -0.44120967389496 0.32671735788216 no 2266 0.329530605214503 744 1112859 SGTC_3040 9091894 49.47 µM -0.442385025196637 0.326279368449519 no 2267 0.329105306689772 714 25236966 SGTC_2295 7971645 200 µM -0.442450020324303 0.32625515528629 no 2268 0.329081794778803 732 2978226 YKL099C UTP11 SGTC_1193 1488-0126 41.5 µM -0.442563706666335 0.326212804549923 no 2269 0.329040670504001 705 1384710 SGTC_1530 rhein 70.4 µM -0.443014682540847 0.326044827907073 no 2270 0.328877557347877 719 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death. SGTC_2208 7283366 200 µM -0.443433072533826 0.32588902020605 no 2271 0.328726259294726 737 898663 SGTC_1962 st076595 64.5 µM -0.443881736387883 0.325721972351414 no 2272 0.328564044805595 730 279619 SGTC_937 3122-0005 46.7 µM -0.444003325121491 0.325676708098362 no 2273 0.328520089941341 756 759535 SGTC_787 4152-0075 138 µM -0.444330510367585 0.325554918493993 no 2274 0.328401822814812 702 9566539 SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM -0.446330451215264 0.324810876901286 no 2275 0.327679281502824 770 6710655 SGTC_1357 1503-1303 39.5 µM -0.446376540051821 0.324793738610043 no 2276 0.327662638056767 724 292895 SGTC_1766 st045414 44.774 µM -0.446979253547159 0.324569651686675 no 2277 0.327445019708035 737 253960 SGTC_21 0849-0113 22.993 µM -0.447032976317436 0.324549680815748 no 2278 0.327425625176001 742 1560156 SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM -0.447717694580843 0.324295188260441 no 2279 0.32717847489786 730 803109 SGTC_177 1327-0068 8.361 µM -0.447985855944255 0.324195541781624 no 2280 0.327081702214312 721 15389900 YOR207C | YLR033W RET1 | RSC58 SGTC_1317 1273-0028 910 nM -0.44810971067616 0.324149522668486 no 2281 0.32703701008446 737 5917803 YLR359W | YHR072W ADE13 | ERG7 SGTC_985 1493-0307 8.71 µM -0.448332432130488 0.324066775676013 no 2282 0.326956648817354 743 3278274 SGTC_3082 9117008 49.47 µM -0.45018351654876 0.323379384797662 no 2283 0.326289060356268 726 41448529 SGTC_292 k038-0015 474 µM -0.451028861416489 0.323065670464292 no 2284 0.325984373927338 763 46368540 SGTC_601 0986-0029 62.9 µM -0.451892571867879 0.322745270453434 no 2285 0.32567318797853 748 24747981 SGTC_2239 6685329 187.64 µM -0.452013116014975 0.322700564133692 no 2286 0.32562976682063 735 805680 SGTC_2468 5987765 72.9 µM -0.452987559965302 0.322339265337074 no 2287 0.325278849669708 712 26772094 SGTC_1705 st027868 56.3335 µM -0.453072668164105 0.322307717363536 no 2288 0.325248207820416 737 292948 SGTC_1328 1441-0025 69.2 µM -0.454716233429115 0.321698730544049 no 2289 0.324656700301763 735 4562601 SGTC_3081 9117243 49.47 µM -0.455880737496938 0.321267538918422 no 2290 0.324237870913498 748 45595589 SGTC_671 0560-0003 407 µM -0.456547002898265 0.321020942966455 no 2291 0.323998339637722 733 3238678 SGTC_891 0929-0073 133 µM -0.457793565738019 0.320559781255622 no 2292 0.323550379434757 764 5603632 SGTC_1101 ebselen 5.29 µM -0.459828320402889 0.319807625657531 no 2293 0.322819726823596 756 3194 A potent scavenger of hydrogen peroxide and hydroperoxides. SGTC_1947 st076332 61.6 µM -0.460002961154888 0.319743103425939 no 2294 0.322757047521332 751 24208416 SGTC_3310 9130229 44.1445 µM -0.46026711517716 0.319645520263637 no 2295 0.322662251097188 759 7761258 SGTC_961 1252-1571 372 µM -0.461995304748488 0.319007404786961 no 2296 0.322042343753386 766 6813498 SGTC_331 k048-0133 24.5 µM -0.462421963939767 0.318849947884222 no 2297 0.321889375776567 727 6813582 SGTC_118 0083-0097 135.343 µM -0.462918929204631 0.318666586016862 no 2298 0.321711239363614 757 5207356 SGTC_2839 9003951 25.97 µM -0.463070260068303 0.318610759320224 no 2299 0.321657003192011 758 2990634 SGTC_1166 k206-0078 225 µM -0.463871013645617 0.318315425960467 no 2300 0.32137008068005 724 5404595 SGTC_1544 7-methoxy-4-methylcoumarin 105 µM -0.464071927317499 0.318241343232917 no 2301 0.321298106890016 739 390807 SGTC_2171 5739187 198.077 µM -0.464825557728002 0.317963522526848 no 2302 0.321028191859654 721 2262761 SGTC_2594 a-mangostin 100 µM -0.465832214879849 0.317592585023899 no 2303 0.320667802025812 772 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis. SGTC_388 3',4'-dichloroisocoumarin 16.7 µM -0.46596661164638 0.317543075748733 no 2304 0.32061969988403 723 1609 A potent and irreversible inhibitor of serine proteases. SGTC_1311 1190-0148 100 µM -0.466371727295488 0.317393858406708 no 2305 0.320474722581795 745 1961333 SGTC_2104 5389443 200 µM -0.468591298071206 0.316576845046944 no 2306 0.319680899247235 759 2244536 SGTC_2052 5265182 7.135 µM -0.468734603396252 0.316524125731208 no 2307 0.319629674821691 755 1239884 SGTC_1624 st003710 6.25 µM -0.46899503165507 0.3164283286485 no 2308 0.319536593663503 785 24207033 SGTC_1637 st007924 17.4 µM -0.469001637075409 0.316425899041587 no 2309 0.319534232930127 735 683336 SGTC_273 hydroxyurea 18.1 mM -0.469392494001391 0.316282148083798 no 2310 0.319394556282211 758 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12 SGTC_758 0868-0029 16 µM -0.470109876104244 0.316018378605883 no 2311 0.319138259269027 709 762687 SGTC_2879 9041815 71.43 µM -0.470483631744238 0.315880991956836 no 2312 0.319004762916075 747 4942971 SGTC_1001 4048-4355 44.4 µM -0.470616782283967 0.315832054071368 no 2313 0.318957210476965 761 21824233 SGTC_2070 5230947 200 µM -0.472506013926034 0.31513803779012 no 2314 0.318282825074077 780 2835538 SGTC_3025 9087895 49.47 µM -0.473570863621059 0.314747148429073 no 2315 0.317902978399024 739 17173641 SGTC_333 3486-0131 40.1 µM -0.474572963977251 0.314379482833388 no 2316 0.317545690185402 751 6744690 SGTC_486 niguldipine 82 µM -0.474651407292556 0.314350710137475 no 2317 0.317517729222114 732 1236 A calcium channel blocker. SGTC_2053 5265679 138 µM -0.474757642180873 0.314311745401222 no 2318 0.317479863667727 745 764595 SGTC_2283 7944793 200 µM -0.475242366105336 0.314133985060743 no 2319 0.31730711660522 728 2970533 SGTC_1145 3546-0597 10.2 µM -0.476660942161338 0.313614005682683 no 2320 0.316801789838204 741 875334 SGTC_456 gingerol 170 µM -0.477380819327971 0.313350276034052 no 2321 0.316545484980768 776 442793 A herb. SGTC_2195 6536160 144.242 µM -0.478419931118462 0.312969761891317 no 2322 0.316175675251781 731 3834386 SGTC_1978 st071761 42 µM -0.478935188947254 0.31278115256616 no 2323 0.315992368173698 727 5147680 SGTC_2006 4011487 200 µM -0.481489296204514 0.311846949854688 no 2324 0.315084392678827 742 45595294 SGTC_1849 st056239 19.2 µM -0.482585242490756 0.311446461601082 no 2325 0.314695129790332 766 5393181 SGTC_3323 9138564 53.9225 µM -0.482931736543008 0.31131988973045 no 2326 0.314572103357099 733 43912313 YNL103W MET4 SGTC_1187 1391-0724 117 µM -0.483090835616079 0.311261779414517 no 2327 0.314515620418322 751 6997986 SGTC_1112 tnp00069 1.16933 µM -0.483486254021311 0.311117374757177 no 2328 0.314375258809738 749 145826 SGTC_3062 9077494 49.47 µM -0.483844959003216 0.310986402789158 no 2329 0.314247952569226 712 16459633 SGTC_148 3253-0744 288.01 µM -0.48526923659619 0.310466600520087 no 2330 0.313742687276502 729 6893655 SGTC_620 0109-0052 432 µM -0.485447986444139 0.310401390931728 no 2331 0.313679300053841 767 493037 SGTC_64 000l-0018 272.079 µM -0.485491428307387 0.31038554384054 no 2332 0.313663895785816 755 6811119 SGTC_2584 androsterone 48.74 µM -0.485758280061683 0.31028820711794 no 2333 0.313569278612861 751 2754130 A steroid. SGTC_132 0417-1715 25.805 µM -0.485768177875816 0.310284597051353 no 2334 0.313565769397574 779 6769098 SGTC_2363 9053361 176 µM -0.486519872286799 0.310010482183219 no 2335 0.313299309616948 773 6469797 YMR079W SEC14 SGTC_1186 1319-0216 26 µM -0.487680770856378 0.309587353286581 no 2336 0.312887987076979 740 4565136 SGTC_2241 6772625 37.8075 µM -0.488223657228348 0.309389566445257 no 2337 0.312695714735122 751 2285411 SGTC_1971 st069429 63.5 µM -0.488998376462455 0.309107412812012 no 2338 0.312421423136236 763 1246522 YGL099W LSG1 SGTC_726 3448-4391 34.2 µM -0.489608457205571 0.308885299920475 no 2339 0.31220549538811 777 1356692 SGTC_2705 st078069 42.8 µM -0.493177732772988 0.307587231389764 no 2340 0.310943505022135 766 1530061 SGTC_2254 7938975 95.19 µM -0.493216161148414 0.307573268879428 no 2341 0.310929929939099 777 2969277 SGTC_1765 st044815 90.4 µM -0.493244100555154 0.307563117590816 no 2342 0.310920060316594 751 645695 SGTC_3297 9117502 71.43 µM -0.493807609053087 0.307358408225308 no 2343 0.310721029437085 750 7453720 SGTC_3195 9113082 49.47 µM -0.494182119540692 0.307222390569734 no 2344 0.31058878317501 760 17018038 SGTC_992 3909-8734 162 µM -0.494422443889048 0.30713512165441 no 2345 0.31050393329695 777 4288319 SGTC_1306 1185-0270 9.02 µM -0.494995015564688 0.306927247876723 no 2346 0.31030181947412 765 1548076 SGTC_2757 clomiphene 4.22 µM -0.495160115288797 0.306867319475658 no 2347 0.310243551055153 790 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined. SGTC_1473 k844-0725 134 µM -0.495666663397513 0.30668348331232 no 2348 0.310064805458458 746 54682906 SGTC_1002 4049-0206 172 µM -0.495688683302053 0.306675492962974 no 2349 0.310057036313728 751 4662749 SGTC_139 0099-0334 718.624 µM -0.495886787800759 0.306603611036076 no 2350 0.309987144160284 756 97690 SGTC_638 3970-0837 4.09 µM -0.495953738763745 0.306579319658986 no 2351 0.309963525113147 740 4118451 YLR208W SEC13 SGTC_2950 9072895 21.46 µM -0.496144533224061 0.306510099622417 no 2352 0.309896220699405 749 17332245 SGTC_956 1185-0240 191 µM -0.497003779728849 0.306198451431559 no 2353 0.309593192961623 755 1416193 SGTC_3254 9136651 49.47 µM -0.497388819775418 0.306058843109074 no 2354 0.309457444078973 784 16454030 SGTC_1523 st012844 44.7 µM -0.500263755858501 0.305017336392213 no 2355 0.308444685557331 759 4274103 SGTC_1524 corynanthine 62.1 µM -0.50045200759018 0.304949193138479 no 2356 0.308378420512806 780 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist. SGTC_2638 epoxomicin 18 µM -0.502105975778787 0.304350781658109 no 2357 0.307796488450146 744 9915668 A protesome inhibitor. SGTC_2539 epi(13)torulosol 80 µM -0.502168818031202 0.304328055423917 no 2358 0.307774387554374 768 6708597 SGTC_472 calcifediol 10 µM -0.503481171852831 0.303853629350567 no 2359 0.307313007304669 743 5283731 A vitamin D metabolite. SGTC_159 3970-0959 50 µM -0.504422041410848 0.303513700897682 no 2360 0.306982416180381 746 6615653 SGTC_2790 5423970 71.43 µM -0.506909016218917 0.302615996251351 no 2361 0.306109329557083 761 1376240 YKL165C | YIL048W MCD4 | NEO1 SGTC_2132 5317594 122.667 µM -0.507927902635155 0.302248560362714 no 2362 0.305751952913637 777 794577 SGTC_2481 5478948 45.16 µM -0.514683232782288 0.299817500967244 no 2363 0.303387196038676 748 77792 SGTC_3188 9110789 49.47 µM -0.516711503906641 0.299089313311527 no 2364 0.302678782158514 772 849217 SGTC_2743 auranofin 4.32 µM -0.516938785979926 0.299007764803092 no 2365 0.302599445586359 725 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold. SGTC_2662 daunorubicin 22.37 µM -0.520788133311917 0.297628160524549 no 2366 0.30125718529101 751 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_1428 4049-0204 61.7 µM -0.52173368549323 0.297289720028169 no 2367 0.30092788369122 784 X1428 SGTC_416 estradiol valerate 100 µM -0.522266945933228 0.297098928267415 no 2368 0.300742239994308 771 13791 A steroid. SGTC_413 propylparaben 100 µM -0.523267333816646 0.296741157160156 no 2369 0.300394114934523 771 7175 A pharmaceutical preservative. SGTC_739 1486-1183 203 µM -0.523539853272279 0.296643729573875 no 2370 0.300299312431505 759 4346692 SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM -0.524934186517529 0.29614547521628 no 2371 0.299814471528957 763 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_2695 st077686 51.995 µM -0.525029166062674 0.296111548973075 no 2372 0.299781457911041 755 2876092 SGTC_1866 st057638 64 µM -0.525072960041311 0.296095906572316 no 2373 0.299766236265079 757 688802 SGTC_2765 myclobutanil 7.74 µM -0.525319164573176 0.296007973917561 no 2374 0.299680668500187 805 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11 SGTC_2785 7756463 72.73 µM -0.526385648947502 0.295627214464969 no 2375 0.299310142379991 789 2201551 SGTC_155 k072-0202 43.6 µM -0.526490774891423 0.295589694277911 no 2376 0.299273629978554 788 5857737 SGTC_3244 9134489 49.47 µM -0.527085277138478 0.29537755346295 no 2377 0.299067185162962 792 16584271 SGTC_2329 6138490 200 µM -0.527283918874957 0.295306686218356 no 2378 0.298998219927178 771 720019 SGTC_1375 2910-0797 186 µM -0.528021998398596 0.295043438215527 no 2379 0.298742033809517 785 742508 SGTC_1664 st014217 9.02 µM -0.52859685636474 0.294838480733717 no 2380 0.298542570755512 771 3982782 SGTC_2829 7992743 58.44 µM -0.529165369712668 0.294635849907937 no 2381 0.298345368745801 767 16462845 SGTC_2860 9025725 38.96 µM -0.529836675779253 0.29439666421367 no 2382 0.298112587080673 787 40546248 SGTC_1365 1672-3266 55.4 µM -0.530427814664008 0.294186116264307 no 2383 0.297907672677387 769 6415873 SGTC_1868 st057644 42.7 µM -0.530831522046347 0.294042366424099 no 2384 0.297767767085169 766 688665 SGTC_1457 k015-0032 57.3 µM -0.530867274901081 0.294029637315177 no 2385 0.297755378307409 790 4302660 SGTC_2397 5161689 200 µM -0.531456999254599 0.293819714186749 no 2386 0.297551065931166 784 2259942 SGTC_989 1501-0895 10.3 µM -0.533623308878502 0.293049172618078 no 2387 0.296801089198052 786 2830112 SGTC_890 0929-0006 47.2 µM -0.535022378994121 0.292552031631616 no 2388 0.296317191242167 770 1378169 SGTC_1772 st048439 82.2 µM -0.535830281699725 0.292265132745642 no 2389 0.296037925891583 755 2927068 YDL195W SEC31 SGTC_562 3772-2733 112 µM -0.53603280571873 0.292193233820125 no 2390 0.29596793895197 772 2876874 YIL048W NEO1 SGTC_2676 harmalol 100 µM -0.537671050257097 0.291611936323482 no 2391 0.295402084476313 762 5459187 A monoamine oxidase inhibitor SGTC_1676 st018489 23.4 µM -0.537853157245616 0.29154735270255 no 2392 0.2953392149361 775 3696235 SGTC_1804 st050076 49.1 µM -0.539930735323677 0.290811019301942 no 2393 0.294622400369605 770 3895976 SGTC_124 0136-0217 7.121 µM -0.542700502150598 0.289830715392542 no 2394 0.293668014219649 788 3976905 SGTC_2936 9038235 15.59 µM -0.54324076180884 0.289639682049784 no 2395 0.29348202238422 759 4749415 SGTC_71 0417-1750 47.813 µM -0.543379053779272 0.289590792144618 no 2396 0.293434422238804 711 6811472 SGTC_2485 5633444 17.78 µM -0.543401234534196 0.289582951015888 no 2397 0.293426787947899 759 5724239 SGTC_1060 3448-7350 82 µM -0.543741465924529 0.289462688155918 no 2398 0.293309696819957 787 570178 SGTC_526 4469-0568 170 µM -0.545445870554784 0.288860579286694 no 2399 0.292723449711089 758 2901964 SGTC_1830 st055982 50.3 µM -0.546054307648693 0.288645781778725 no 2400 0.292514303537174 808 455313 An antimicrobial agent. SGTC_2898 9056270 58.44 µM -0.54631524532296 0.288553685595989 no 2401 0.292424629243878 751 19154699 SGTC_2576 guaiol 23.12 µM -0.547311011788142 0.288202363861163 no 2402 0.292082539915708 775 227829 SGTC_315 k915-0449 187 µM -0.547579750135081 0.288107583424128 no 2403 0.291990248469779 775 20970215 YNL149C PGA2 SGTC_1337 1486-1011 40.3 µM -0.547943559017018 0.28797929631424 no 2404 0.291865329069951 768 X1337 SGTC_56 0957-0365 83.25 µM -0.548343376600146 0.287838342845301 no 2405 0.291728074245254 759 6752360 SGTC_3042 9091578 49.47 µM -0.548792215152499 0.287680146139568 no 2406 0.291574026683225 765 25236497 SGTC_126 0417-1624 672.48 µM -0.548852799994171 0.287658795679588 no 2407 0.291553236038376 802 41912 YDL195W SEC31 SGTC_1069 diphenylcyclopropenone 8.49 µM -0.549033113285387 0.287595256630449 no 2408 0.291491362776739 815 65057 A dermal irritant. YDR527W RBA50 SGTC_2140 5586273 200 µM -0.551022823731572 0.286894560589828 no 2409 0.290809014381153 777 854421 SGTC_1889 st059080 5.18 µM -0.551687104783377 0.286660807747108 no 2410 0.290581373196813 778 176925 Isolated from Daphnopsis sellowiana. SGTC_3057 9095946 49.47 µM -0.551786884653976 0.28662570416442 no 2411 0.290547187030229 795 24540043 SGTC_1266 0828-0227 32.9 µM -0.552605520923554 0.286337776527536 no 2412 0.290266780345707 769 3913820 SGTC_1463 k081-0032 34.1 µM -0.552777636546347 0.286277258148274 no 2413 0.290207841879627 788 977755 SGTC_2011 4012611 177 µM -0.552825880494236 0.286260295957895 no 2414 0.290191322454611 771 2049887 SGTC_1514 1189-1591 158 µM -0.553979100795585 0.28585497494219 no 2415 0.289796574354593 811 767698 YMR146C TIF34 SGTC_1867 st057372 64 µM -0.55469435249044 0.2856037234383 no 2416 0.289551869857002 751 688837 SGTC_1225 1216-0074 20.6 µM -0.555165082508924 0.285438424151415 no 2417 0.289390874957362 786 4241466 SGTC_1004 4084-0029 199 µM -0.555605340910346 0.28528386636953 no 2418 0.289240339760203 758 716894 YLR208W SEC13 SGTC_1610 st001799 48.1 µM -0.556690193285562 0.284903186710175 no 2419 0.28886955917967 779 621897 SGTC_2473 5854593 8.94 µM -0.558067438584127 0.284420254398918 no 2420 0.288399167145257 791 2872951 SGTC_745 0469-0705 296 µM -0.55904084150836 0.284079165857037 no 2421 0.288066923630748 792 3486736 SGTC_955 1216-0110 33 µM -0.55918399632842 0.284029019716603 no 2422 0.288018077028558 785 3619719 SGTC_2361 9034121 116 µM -0.55960202858933 0.28388261015919 no 2423 0.287875460444443 799 6496917 SGTC_196 k015-0023 18.111 µM -0.559858579507708 0.283792774921867 no 2424 0.287787951622072 774 5211998 SGTC_915 methyl methanesulfonate (MMS) 110 mM -0.559914127472091 0.283773325743253 no 2425 0.287769006017177 787 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks. SGTC_1079 idarubicin 2.36 µM -0.562168952165215 0.282984376344318 no 2426 0.287000456476948 807 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_452 diindolylmethane 8 µM -0.562699085437544 0.282799038954118 no 2427 0.286819903564568 781 3071 Inhibits expression of several cancer promoting factors. SGTC_1264 0783-0040 158 µM -0.563966115708106 0.282356314851662 no 2428 0.286388596327464 775 2855798 SGTC_2526 patulin 37.61 µM -0.564785632938475 0.282070137872355 no 2429 0.286109790157967 785 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.  SGTC_858 0438-0351 2.77 µM -0.564870384660119 0.282040550380193 no 2430 0.286080964318539 783 2799119 SGTC_157 1348-1695 65.819 µM -0.565309830515234 0.281887160348802 no 2431 0.285931521690617 748 5380510 SGTC_3043 9092303 49.47 µM -0.568222101516789 0.280871639625514 no 2432 0.284942082938306 774 25236084 SGTC_2959 9079155 11 µM -0.568352633612321 0.280826163997782 no 2433 0.284897773161879 809 16189457 SGTC_1492 4158-0558 28.5 µM -0.568629551095116 0.280729701457183 no 2434 0.284803783013776 761 3967268 SGTC_38 0929-0051 58.268 µM -0.568727843032164 0.280695465905788 no 2435 0.284770424743159 788 1379719 SGTC_1937 st074714 47.2 µM -0.56957283017807 0.280401236179194 no 2436 0.284483730352029 774 17250970 SGTC_439 amiodarone 34.4 µM -0.57017106560811 0.280193017243013 no 2437 0.284280839367976 777 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1 SGTC_3303 9125618 40.5795 µM -0.570465848954183 0.280090443932963 no 2438 0.284180889318153 783 22695467 SGTC_1153 4055-0057 267 µM -0.570741189114954 0.279994652547478 no 2439 0.284087546908297 788 882706 SGTC_926 2268-1401 59.4 µM -0.571316426910349 0.279794577450857 no 2440 0.283892584254696 791 2931578 SGTC_3160 9100216 49.47 µM -0.572253467085547 0.279468811423337 no 2441 0.283575134806589 773 17191039 SGTC_2616 abietic acid 100 µM -0.572805464371588 0.279276993458053 no 2442 0.283388209409095 801 6708678 Abietic acid is an inhibitor of 5α-reductase. SGTC_1404 3909-7820 48.3 µM -0.573482022945843 0.27904197798873 no 2443 0.283159183850556 793 23741373 SGTC_2693 st077581 40.7 µM -0.574326987734732 0.27874859855696 no 2444 0.282873274955089 795 25238761 SGTC_1440 4100-1550 40 µM -0.57563480165802 0.278294809967904 no 2445 0.282431026355767 801 742806 SGTC_1533 dihydroergotamine mesylate 29.4 µM -0.576286407432661 0.278068848639131 no 2446 0.282210804409403 810 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release. SGTC_2516 gossypol 71.55 µM -0.57773335592619 0.277567401720792 no 2447 0.281722077758303 792 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_2678 equilin 100 µM -0.578372532130756 0.277346032941124 no 2448 0.281506317253329 764 3247 Equilin is an estrone commonly used hormone replacement therapy SGTC_191 3914-0123 66.505 µM -0.581574376312718 0.276238424950385 no 2449 0.280426703296143 805 3144412 SGTC_862 0452-0056 10.2 µM -0.582321351650064 0.275980337777657 no 2450 0.280175123061721 783 1575396 YLR359W | YHR072W ADE13 | ERG7 SGTC_855 0428-0020 25 µM -0.583102562832509 0.27571054854147 no 2451 0.279912129289852 766 6812414 SGTC_1074 carmofur 3.8 µM -0.584518573953835 0.275221863500802 no 2452 0.279435736286865 806 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_820 1582-0060 59.9 µM -0.585716395089313 0.274808812042089 no 2453 0.279033057311606 788 3848840 SGTC_1799 st045822 46.1415 µM -0.589429979173909 0.273530181340737 no 2454 0.27778643538263 805 3674992 SGTC_1660 st012960 28.1 µM -0.59358031243582 0.272104665857541 no 2455 0.276396426042654 809 24207266 SGTC_1886 st057356 49.9 µM -0.594444553522435 0.271808290163574 no 2456 0.276107408373061 769 24207747 SGTC_1814 st052110 31.539 µM -0.594774214046411 0.271695281447008 no 2457 0.275997203103474 809 674163 SGTC_2565 isoliquiritigenin 100 µM -0.594796426337304 0.271687667841455 no 2458 0.275989778327906 768 638278 Binds to benzodiazepine receptor 65X better than valium. SGTC_538 2922-0838 53.3 µM -0.595321355328106 0.271507771246401 no 2459 0.275814341869772 786 777039 SGTC_1429 4049-0205 9.46 µM -0.595331109878222 0.271504428859923 no 2460 0.275811082321367 790 22774478 SGTC_815 1582-0027 36.9 µM -0.595379370628364 0.271487892665487 no 2461 0.275794955946219 806 3128206 SGTC_1569 carminic acid 40.6 µM -0.596519971476938 0.271097220194821 no 2462 0.275413958036306 787 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_286 k060-0067 22.9 µM -0.597841496750149 0.270644929343729 no 2463 0.274972849542063 781 5985051 SGTC_1032 k061-1018 98.7 µM -0.598215869230711 0.270516869230033 no 2464 0.274847952023526 814 4005393 SGTC_1330 1469-0054 61.8 µM -0.598782608036446 0.270323064749491 no 2465 0.274658930795491 803 7102664 SGTC_793 0488-0545 106 µM -0.599123117171391 0.270206656145982 no 2466 0.274545393525709 812 292548 SGTC_1135 dihydrocapsaicin 536.708 nM -0.60178038428324 0.269299088078517 no 2467 0.273660166978089 805 107982 A Capsaicinoid. SGTC_269 exalamide 29 µM -0.602137500290896 0.269177234629068 no 2468 0.273541307152839 783 3316 A derivative of salicylamide. SGTC_1840 st055363 71 µM -0.602924909162605 0.268908656437289 no 2469 0.273279322173973 803 676033 SGTC_2330 7979373 200 µM -0.602958048127383 0.268897355981167 no 2470 0.273268298975247 793 1863007 SGTC_2610 ononetin 44.17 µM -0.603631379075653 0.268667800377759 no 2471 0.273044372859149 792 259632 SGTC_1698 5-fluorocytosine 1.055 µM -0.607666736472861 0.26729411137042 no 2472 0.271704264442471 797 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_3024 9090631 49.47 µM -0.607846971873653 0.267232839637274 no 2473 0.271644486242369 790 25236383 SGTC_2716 st080858 38.6235 µM -0.608501516744535 0.267010384164404 no 2474 0.271427450155136 787 5296050 SGTC_2569 tetrandrine 100 µM -0.609112024229442 0.266802979688416 no 2475 0.27122509402433 776 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_3150 9097574 49.47 µM -0.609820417575155 0.266562423047082 no 2476 0.270990387376113 797 17217476 SGTC_688 0527-0193 473 µM -0.611666398901452 0.265936079330057 no 2477 0.270379248686291 820 4007154 SGTC_1972 st070201 17.4 µM -0.612940311441404 0.265504274519553 no 2478 0.269957903714337 793 2829099 SGTC_2624 nerol 100 µM -0.613291332616125 0.265385355082369 no 2479 0.26984186167814 830 637566 A natural product oil. SGTC_1284 0929-0043 16 µM -0.615155363962633 0.264754309213065 no 2480 0.269226061190268 798 1239883 SGTC_2572 astragaloside iv 100 µM -0.616419161207106 0.264326899955025 no 2481 0.268808955099778 789 45006101 An anti-inflammatory agent. SGTC_2124 5246320 200 µM -0.617983762646273 0.263798247467481 no 2482 0.268293021032652 793 579342 SGTC_3306 9127676 59.7925 µM -0.618311466364004 0.263687590224265 no 2483 0.268185022447355 802 41905287 SGTC_788 1182-0090 188 µM -0.618916279489126 0.263483422348766 no 2484 0.26798575668525 790 5715185 SGTC_73 0327-0325 16.231 µM -0.621936486215871 0.262465094493577 no 2485 0.266991816185611 775 53298 SGTC_2574 2',4'-dihydroxychalcone 14.64 µM -0.622015639631815 0.262438433332126 no 2486 0.266965792104695 804 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_901 1112-0062 60.1 µM -0.625208710444145 0.261364072075239 no 2487 0.265917042894603 802 1908457 SGTC_1470 k295-0292 231 µM -0.626524828299743 0.260921900915714 no 2488 0.265485378474873 816 5045612 SGTC_1769 st044406 64.4 µM -0.627078942672076 0.260735852348458 no 2489 0.265303744729599 827 670903 SGTC_3073 9114972 49.47 µM -0.627419921344897 0.260621399824474 no 2490 0.265192006324438 790 41905075 SGTC_1912 st060209 90.8 µM -0.628753950258976 0.260173869793601 no 2491 0.264755076008015 829 688787 SGTC_510 ag-490 170 µM -0.629010793663271 0.260087751385564 no 2492 0.264670994932031 804 5328779 SGTC_1090 efavirenz 20.7 µM -0.629368848630114 0.259967721736154 no 2493 0.264553803582925 796 64139 A non-nucleoside reverse transcriptase inhibitor. SGTC_342 k048-0088 23.3 µM -0.630282562300863 0.259661549874936 no 2494 0.264254864897159 809 6820570 SGTC_397 arbidol 50 µM -0.630415984659667 0.259616857606209 no 2495 0.264211227649501 803 131410 A RNA synthesis inhibitor. SGTC_1543 azetidyl-2-carboxylic acid 198 µM -0.631321950904373 0.259313492647074 no 2496 0.263915018536777 810 16486 A toxic proline analog. SGTC_3210 9128157 49.47 µM -0.632379265035039 0.25895968025392 no 2497 0.263569539842166 811 17590849 SGTC_2019 4016004 108 µM -0.632790592174252 0.258822104041627 no 2498 0.263435200571117 818 45595336 SGTC_1231 0242-0792 125 µM -0.634083591878957 0.25838988205052 no 2499 0.263013135161676 810 3707635 SGTC_2740 felodipine 17.08 µM -0.634120948058219 0.258377400243848 no 2500 0.263000946368196 771 3333 L-type calcium channel blocker SGTC_2226 7298446 200 µM -0.635246425944762 0.258001491270458 no 2501 0.26263385427325 820 3283010 SGTC_870 0573-2213 57.6 µM -0.635471930962399 0.257926206850908 no 2502 0.262560333850176 806 3916321 SGTC_954 1189-0853 2.85 µM -0.636257387185515 0.25766407280193 no 2503 0.262304337229461 825 2828194 SGTC_883 0850-0245 24.6 µM -0.636614714805639 0.257544865945394 no 2504 0.262187919003378 815 6823229 YPR165W RHO1 SGTC_1246 0422-0085 105 µM -0.637327510636829 0.257307158131996 no 2505 0.261955767455358 823 264295 SGTC_1872 amphotericin b 148 nM -0.637423896300175 0.257275023565358 no 2506 0.261924383554718 804 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1 SGTC_127 0180-0333 59.125 µM -0.637855227079229 0.257131245293261 no 2507 0.261783962615327 782 771601 SGTC_1000 4048-0884 8.67 µM -0.63837054318395 0.25695952644469 no 2508 0.261616250662542 817 13040088 SGTC_1363 1636-0063 10.4 µM -0.638597108035772 0.256884047098007 no 2509 0.26154253156484 810 6072185 SGTC_2639 lactacystin 53 µM -0.640101152070702 0.25638327237045 no 2510 0.261053420036081 800 3870 A proteasome inhibitor. SGTC_756 0508-1999 28.3 µM -0.640898124664411 0.256118124970126 no 2511 0.260794437184551 824 6753853 SGTC_2738 aclarubicin 5.55 µM -0.644494213669522 0.254923511253526 no 2512 0.259627504306423 780 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31 SGTC_2640 pentamidine 10.38 µM -0.644814075550936 0.254817395157331 no 2513 0.259523839646749 816 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM -0.646357160028692 0.254305792662555 no 2514 0.259024038849328 808 6708784 An antioxidant flavonoid SGTC_1438 4092-1045 4 µM -0.647672624960726 0.253870081933461 no 2515 0.258598356788334 824 1351342 SGTC_653 0203-0016 55.2 µM -0.648093696852129 0.253730696553869 no 2516 0.258462175261762 817 295302 SGTC_1096 rimcazole 32.2 µM -0.648133733826603 0.253717445401401 no 2517 0.258449228584648 817 18528119 A dopamine reuptake inhibitor. SGTC_2183 6420625 130.508 µM -0.64908552482353 0.253402535438444 no 2518 0.258141548767069 816 2897619 SGTC_446 go6976 132 µM -0.649881904244134 0.253139202952663 no 2519 0.257884253934672 827 3501 A protein kinase C inhibitor. SGTC_2045 5106652 78.05 µM -0.650168525100539 0.253044463535742 no 2520 0.257791684837739 808 673349 SGTC_1403 3909-7815 62.9 µM -0.650238630040188 0.253021293947604 no 2521 0.257769045876336 811 6615483 SGTC_3287 9117173 37.0625 µM -0.652316348995117 0.252335117711289 no 2522 0.25709855768309 785 2789709 SGTC_612 0302-0167 22.4 µM -0.652383710799243 0.252312887595341 no 2523 0.257076834949591 834 235821 SGTC_3178 9107506 49.47 µM -0.653159631046394 0.252056900073323 no 2524 0.25682668619336 809 8897194 SGTC_1597 7-benzyloxygramine 47.5 µM -0.65384509379743 0.251830869855278 no 2525 0.25660580544717 823 260807 SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM -0.653864487661297 0.251824476317406 no 2526 0.256599557486339 818 756377 SGTC_1687 st020778 55.3625 µM -0.65527729380541 0.251358949824541 no 2527 0.25614461860987 801 4259299 SGTC_899 1083-0020 478 µM -0.655478650198177 0.251292638972121 no 2528 0.256079813934012 830 767123 SGTC_1744 st037937 38.9 µM -0.657465240475256 0.250638909516826 no 2529 0.255440907073707 822 1016152 SGTC_2600 tangeritin 87.95 µM -0.657651395592171 0.250577697440923 no 2530 0.255381080479383 831 68077 A bioactive flavone. SGTC_674 0498-0004 451 µM -0.658546802335363 0.250283377848159 no 2531 0.255093416715224 812 4231473 SGTC_13 0199-0087 65 µM -0.658621227566636 0.250258922578206 no 2532 0.255069514048559 809 4589825 SGTC_892 0929-0076 29 µM -0.658683343727655 0.250238512896417 no 2533 0.255049565502789 812 5751038 SGTC_2044 5102272 200 µM -0.659118409399831 0.250095586889041 no 2534 0.254909867458056 814 592666 SGTC_3255 9139072 49.47 µM -0.659365787306192 0.250014338620573 no 2535 0.254830453150663 821 17646060 SGTC_3027 9089541 49.47 µM -0.659410425394627 0.249999679274407 no 2536 0.254816124621091 819 9943819 SGTC_1973 st070275 50.2 µM -0.660046811689636 0.249790736805079 no 2537 0.254611894726571 798 17118334 SGTC_192 3455-0609 60.9 µM -0.661641899449799 0.249267434972505 no 2538 0.254100374150407 804 3769639 SGTC_1848 st056003 16.4 µM -0.662470476617986 0.248995833161004 no 2539 0.253834874844273 804 146492 SGTC_1455 4262-0120 131 µM -0.662795145014669 0.248889452084007 no 2540 0.253730881730118 815 1529587 SGTC_886 0866-0150 153 µM -0.663021056633044 0.248815443998623 no 2541 0.253658534168916 811 271463 SGTC_2691 st077356 60.2 µM -0.663205203757919 0.248755126525954 no 2542 0.25359956958541 839 2839272 SGTC_1988 st071872 53.4 µM -0.663884945016115 0.248532544404715 no 2543 0.253381976302341 806 16414116 SGTC_1661 st013063 9.66 µM -0.665348927660084 0.248053522072812 no 2544 0.252913671476974 841 721395 SGTC_47 0149-0135 24.25 µM -0.665660748244094 0.247951556509717 no 2545 0.252813983897419 813 5239155 SGTC_2957 9076800 11.52 µM -0.665804965612637 0.247904404888837 no 2546 0.252767885277489 832 16459615 SGTC_755 1995-0008 37.3 µM -0.667979959276894 0.24719387515103 no 2547 0.252073192563498 793 689533 SGTC_2488 5268135 45.7 µM -0.66805646345341 0.247168902510289 no 2548 0.252048775489646 832 1270356 YLR208W SEC13 SGTC_1023 4482-3888 16 µM -0.670813632329891 0.246269803359831 no 2549 0.251169630956544 828 3303168 SGTC_2453 5731132 22.18 µM -0.67135687017492 0.246092863182206 no 2550 0.250996606838203 839 1362040 SGTC_1171 0368-0077 21.4 µM -0.672380230929388 0.245759725555642 no 2551 0.250670832438715 834 3239779 SGTC_1726 st035556 14.5795 µM -0.673605798324326 0.245361081828287 no 2552 0.250280982914636 807 5919439 SGTC_576 1073-0113 22.7 µM -0.674349128968965 0.245119466020561 no 2553 0.250044688250705 855 5439563 SGTC_1490 4089-0339 670 nM -0.674451240697149 0.245086285127147 no 2554 0.250012237575514 828 742542 SGTC_584 0986-0246 15.4 µM -0.674683388147698 0.245010858514334 no 2555 0.249938470413957 858 53315 YDR232W HEM1 SGTC_252 miconazole 1.30953 nM -0.675753777861648 0.244663241701055 no 2556 0.249598492909115 823 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_2390 9097792 176.6 µM -0.676950155805948 0.244275023818694 no 2557 0.249218789921923 810 4497149 SGTC_114 0364-0001 490.298 µM -0.677392520694713 0.244131563046045 no 2558 0.249078471254286 828 4003655 SGTC_1006 4099-6547 255 µM -0.677741151424594 0.244018532672455 no 2559 0.248967914794709 842 3146833 SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM -0.678191314774551 0.243872625942142 no 2560 0.248825199332621 833 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding. SGTC_3152 9099253 49.47 µM -0.679060121825977 0.243591161779149 no 2561 0.248549884281465 826 25236131 SGTC_3280 9140961 49.47 µM -0.67981484427563 0.243346799641744 no 2562 0.248310853132786 848 4901226 SGTC_722 3534-0461 190 µM -0.681013783584778 0.242958882620339 no 2563 0.247931384419621 817 658262 SGTC_253 dyclonine 31.25 µM -0.681041844868622 0.242949807395254 no 2564 0.247922506627846 820 3180 An oral anasthetic. SGTC_1047 2043-3044 82 µM -0.681285900786469 0.242870885654704 no 2565 0.24784530143457 864 669592 SGTC_3265 9137266 49.47 µM -0.68147139325687 0.242810911186855 no 2566 0.247786630918086 780 17224265 SGTC_332 4112-0506 40.9 µM -0.68155178251523 0.242784921769834 no 2567 0.24776120642487 841 2790355 SGTC_2172 5754775 163.918 µM -0.681953209655737 0.242655165056873 no 2568 0.247634268996007 824 2263357 SGTC_2154 5570129 200 µM -0.682173047127708 0.242584121033263 no 2569 0.247564767733378 855 673366 SGTC_2439 5492030 7.2 µM -0.682551469666678 0.242461854075359 no 2570 0.247445154469538 827 5722370 SGTC_3236 9132701 49.47 µM -0.684390146102194 0.241868259772871 no 2571 0.246864418343079 831 24282524 SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM -0.684911442487168 0.241700109157466 no 2572 0.24669990250218 825 115019 SGTC_2201 6605497 169.863 µM -0.685122551898682 0.241632031254407 no 2573 0.246633295223594 825 670741 SGTC_2507 purpurin 79.67 µM -0.686176198375053 0.241292410324379 no 2574 0.246301002535597 841 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1 SGTC_2927 9011802 47.9 µM -0.688598294898516 0.240512682577435 no 2575 0.245538047193244 823 43912568 SGTC_649 1123-0311 367 µM -0.688736295202501 0.240468298504125 no 2576 0.24549461564771 827 693629 YIL048W NEO1 SGTC_1613 st002381 52.1 µM -0.688745278657812 0.240465409372823 no 2577 0.2454917885119 832 551167 SGTC_2302 7771753 200 µM -0.689951243704986 0.240077735680772 no 2578 0.245112424454812 825 2203047 SGTC_1384 3089-0840 101 µM -0.690025160814401 0.240053985118536 no 2579 0.24508918238642 815 1069836 SGTC_72 0744-0168 198.391 µM -0.690655453015145 0.2398515157923 no 2580 0.244891045108949 848 677577 SGTC_1738 st035555 74 µM -0.691134043770553 0.239697839899163 no 2581 0.244740653962286 838 5331140 SGTC_400 oxethazaine 37.5 µM -0.691691106629426 0.239519034238832 no 2582 0.24456566657974 830 4621 A local anesthetic. SGTC_1161 k007-0610 110 µM -0.692480985590292 0.239265624309554 no 2583 0.244317661401667 834 5843850 SGTC_2852 9023854 51.95 µM -0.692609112176032 0.239224532394065 no 2584 0.244277445162623 849 19798528 SGTC_2173 5763948 167 µM -0.692842802308567 0.239149594763875 no 2585 0.244204103938207 835 2867177 SGTC_2910 7948405 25.97 µM -0.693097983506269 0.239067780229143 no 2586 0.244124031527854 817 2971328 SGTC_363 0455-0021 3.06 µM -0.693151628511452 0.239050582863203 no 2587 0.244107200251673 832 4597466 SGTC_3133 9127736 49.47 µM -0.693182056544672 0.239040828629879 no 2588 0.244097653646043 823 27243420 SGTC_952 1185-0122 232 µM -0.693252740320308 0.239018170560551 no 2589 0.244075477829489 828 678600 SGTC_1147 3809-1045 12.3 µM -0.693511072933927 0.238935370622252 no 2590 0.243994439666979 822 325925 SGTC_475 α-linolenic acid 10 µM -0.69361930011342 0.238900686657342 no 2591 0.243960493441662 819 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_1150 3909-7983 10.9 µM -0.694762249632052 0.238534569522238 no 2592 0.24360215478063 839 23965914 SGTC_518 1021-0119 62.6 µM -0.695108392623546 0.238423751337479 no 2593 0.243493687792064 842 1097762 SGTC_1372 2752-0194 270 µM -0.695279874772565 0.238368861520853 no 2594 0.243439961999308 822 823334 SGTC_2868 9035608 32.47 µM -0.696145753134781 0.23809180775556 no 2595 0.24316877795239 833 6462614 SGTC_2477 5967686 25.23 µM -0.696498159712822 0.237979099315231 no 2596 0.243058454680533 831 776118 SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM -0.697731527316822 0.237584867913269 no 2597 0.242672553827789 823 66535 A nucleotide analog. SGTC_1612 st002233 45.4 µM -0.698536366341324 0.237327803981276 no 2598 0.242420911627877 823 1035021 SGTC_2970 9090938 41.86 µM -0.700296308423511 0.236766214643304 no 2599 0.241871138348452 829 17217104 SGTC_1474 0330-0125 5.35 µM -0.700712621836768 0.236633477934189 no 2600 0.241741188761296 839 X1474 SGTC_1812 st052057 4.327 µM -0.701852086152247 0.23627038239662 no 2601 0.241385706090682 833 3645418 SGTC_1665 st014639 11.4 µM -0.70248979114378 0.236067308746623 no 2602 0.241186883042237 837 981133 YIL048W NEO1 SGTC_1590 st077108 57.8 µM -0.704008952799431 0.235583927709398 no 2603 0.240713599105274 818 5489485 SGTC_1636 st007707 68.9 µM -0.704665744162529 0.235375112887988 no 2604 0.240509137069199 850 403051 SGTC_3225 9130819 49.47 µM -0.706242934849118 0.23487409137696 no 2605 0.240018537134302 853 4547121 SGTC_1397 3532-0190 20.1 µM -0.707217560275636 0.234564779887984 no 2606 0.239715643759624 811 5322280 SGTC_925 2064-1272 59.6 µM -0.707272685055743 0.234547291975615 no 2607 0.239698518355544 846 6815817 SGTC_2717 st081029 62.2815 µM -0.708849217310498 0.234047454615893 no 2608 0.239209025827025 844 5292846 SGTC_1120 ficusin 1.78878 µM -0.709255325575384 0.233918794181506 no 2609 0.239083023082596 862 6199 A DNA cross-linker. SGTC_1064 honokiol 6.76 µM -0.709284014922594 0.233909706501511 no 2610 0.239074123044024 842 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis. SGTC_2175 5807670 165.306 µM -0.711166278924572 0.233313905383116 no 2611 0.238490601074888 800 241186 SGTC_615 k087-0205 167 µM -0.711979542553116 0.233056740317108 no 2612 0.238238722085112 845 9642773 SGTC_578 3460-0051 92 µM -0.713226947461163 0.232662599886688 no 2613 0.237852666894079 870 2876744 SGTC_1863 st057641 20.1 µM -0.713426709187753 0.232599515945484 no 2614 0.237790875186541 854 3921635 SGTC_2021 4019055 173 µM -0.71416416553322 0.232366712598025 no 2615 0.237562836250529 851 44827708 YER133W GLC7 SGTC_2771 fluoxetine 41.05 µM -0.7142117214706 0.232351704387977 no 2616 0.237548134950832 844 3386 A selective serotonin reuptake inhibitor. SGTC_888 0916-0002 6.97 µM -0.717505513526021 0.231313527411109 no 2617 0.236531117813538 833 2802138 YIL048W NEO1 SGTC_2360 9040895 200 µM -0.718582264301996 0.230974706153944 no 2618 0.236199172188735 838 4914414 SGTC_2736 butenafine 14.65 µM -0.720793429369574 0.230279788100143 no 2619 0.235518309328663 838 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_3076 9116187 49.47 µM -0.721780072794786 0.22997008655206 no 2620 0.235214851436052 826 27241210 SGTC_622 1348-1566 26.3 µM -0.72303898700161 0.229575259522421 no 2621 0.23482796602311 841 7340407 SGTC_2988 9073640 71.4286 µM -0.725021045321986 0.228954406731546 no 2622 0.234219559795588 842 9102229 SGTC_1070 indatraline 8.81 µM -0.727596299443926 0.228149152560947 no 2623 0.233430373279225 848 10314472 A monamine transport inhibitor. YGL099W LSG1 SGTC_2085 5307070 144.047 µM -0.727805545397465 0.228083793635074 no 2624 0.233366314728453 863 2840351 SGTC_385 1494-0393 12.4 µM -0.728185243192549 0.227965220194264 no 2625 0.233250098966862 846 3090647 SGTC_384 k007-0144 5.16 µM -0.729080411533819 0.227685810981935 no 2626 0.232976238058448 862 6824886 SGTC_2257 7960413 200 µM -0.730249498365097 0.227321193959805 no 2627 0.232618845706309 837 2974689 YIL048W NEO1 SGTC_3003 9075612 71.4286 µM -0.732366275040463 0.226661847502717 no 2628 0.231972518722991 860 6501993 SGTC_1400 3771-8998 51.5 µM -0.732789675893852 0.226530093689955 no 2629 0.231843359543589 825 670767 SGTC_1832 st054113 55 µM -0.736453721955273 0.225391724126293 no 2630 0.230727310613561 843 1251267 SGTC_505 gw-5074 63.9 µM -0.736557577103603 0.225359505008746 no 2631 0.230695720686545 846 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases. SGTC_767 0929-0023 86 µM -0.737208932771932 0.22515749357069 no 2632 0.230497651018513 855 1204563 SGTC_2426 5582046 32.21 µM -0.739752924312811 0.224369483573509 no 2633 0.22972496413292 846 2251934 SGTC_340 k038-0059 454 µM -0.740574008648136 0.224115484472693 no 2634 0.229475886082612 854 23733424 SGTC_583 1488-1091 88.9 µM -0.741904407148982 0.223704277999957 no 2635 0.22907262772076 874 4303273 SGTC_258 haloperidol 50.781 µM -0.742554819569435 0.223503401376262 no 2636 0.228875625359631 859 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_3351 9150312 21.596 µM -0.743550919021447 0.223195960029478 no 2637 0.228574102820805 854 4904905 SGTC_1335 1486-0900 202 µM -0.744166798358558 0.223005992312422 no 2638 0.22838778582121 843 X1335 SGTC_1220 1838-0075 193 µM -0.744734771795384 0.222830882798971 no 2639 0.228216037075758 836 5529645 SGTC_1176 0848-0131 83.3 µM -0.744873722352831 0.222788055464847 no 2640 0.228174031055342 857 6769040 SGTC_577 r071-0003 38.6 µM -0.746327490957745 0.22234025632533 no 2641 0.227734804304261 875 4568517 YMR134W ERG29 SGTC_2476 5806916 10.51 µM -0.746892177880292 0.222166456386708 no 2642 0.227564323995883 843 2870194 SGTC_1142 3253-1408 9.78 µM -0.749011336800967 0.221514911314848 no 2643 0.226925186233249 851 256655 SGTC_2685 mycophenolic acid 18.85 µM -0.749711992748686 0.221299731953624 no 2644 0.226714091507496 834 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_684 1140-0066 328 µM -0.75197662741734 0.220605055269451 no 2645 0.226032557251608 847 6813534 SGTC_1755 st041960 45.185 µM -0.752624683353506 0.220406494254794 no 2646 0.225837740314217 866 2257073 SGTC_2181 6316240 54.2555 µM -0.752762911782611 0.220364155032146 no 2647 0.225796198724384 865 12779990 SGTC_1237 0330-0133 46.1 µM -0.752763291979779 0.220364038584583 no 2648 0.225796084470239 891 X1237 YHR072W ERG7 SGTC_1677 st019204 53.9 µM -0.752820808086007 0.220346422840652 no 2649 0.225778800516383 857 3945625 SGTC_3052 9092717 49.47 µM -0.753130754221712 0.220251507993617 no 2650 0.225685672624672 859 25237534 SGTC_854 0422-0053 192 µM -0.753213603598631 0.220226140989009 no 2651 0.225660782987864 868 3596728 SGTC_2886 9058944 51.95 µM -0.753626575136954 0.220099721445287 no 2652 0.225536741111115 813 4949929 SGTC_3095 9117207 49.47 µM -0.755830878534509 0.21942564085494 no 2653 0.224875300319964 840 17015229 SGTC_2307 7538926 6.34 µM -0.761796631355512 0.217607261952722 no 2654 0.223090695619567 871 96582 SGTC_1864 st057645 30.4 µM -0.763105508461769 0.217209478781481 no 2655 0.222700237584954 857 688666 SGTC_3262 9137218 49.47 µM -0.764338924115818 0.216835013925113 no 2656 0.222332647586355 810 17650664 SGTC_662 k832-1615 104 µM -0.76522462489598 0.216566345660996 no 2657 0.222068899337442 846 5878478 SGTC_1658 st012944 20 µM -0.765942741473572 0.216348653794965 no 2658 0.221855186295403 848 24207260 SGTC_3119 9125183 49.47 µM -0.765973389224643 0.216339365969124 no 2659 0.221846068073001 834 22695334 SGTC_2210 7115885 190.385 µM -0.768098701598467 0.215695851492487 no 2660 0.221214274123422 865 2927039 SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM -0.770692483364136 0.214911996715186 no 2661 0.220444614173012 879 6728940 SGTC_1037 k284-1091 78.7 µM -0.771557785160358 0.214650866373853 no 2662 0.220188192612403 856 3334711 SGTC_1319 1306-0155 43.7 µM -0.771578676513882 0.214644564072349 no 2663 0.220182003831842 866 3122360 SGTC_932 2857-0803 154 µM -0.771907120544847 0.214545496390251 no 2664 0.220084719848935 872 674898 SGTC_2364 9055074 200 µM -0.772249901548049 0.214442132638331 no 2665 0.219983215603979 874 6470630 SGTC_2406 ethylparaben 405.7 µM -0.777465610557178 0.212872939791539 no 2666 0.218442058072742 871 8434 A possible steroid mimic. SGTC_1486 3970-0793 4.53 µM -0.778069968936833 0.212691547429713 no 2667 0.218263882850774 878 2844330 SGTC_2896 9052656 71.43 µM -0.778252039530716 0.212636918385401 no 2668 0.21821022173263 851 6469436 SGTC_339 3091-4833 71.4 µM -0.779691221993727 0.212205389923847 no 2669 0.217786323448971 865 3240077 SGTC_975 1335-0046 28.5 µM -0.783606003214232 0.211034164467149 no 2670 0.216635666099744 871 16486740 SGTC_2193 5925765 200 µM -0.784881170544321 0.210653479223438 no 2671 0.216261621467742 872 877370 SGTC_137 0438-0332 85.389 µM -0.789751261576481 0.209203287053237 no 2672 0.214836523859408 878 2063393 YER012W | YPR107C PRE1 | YTH1 SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM -0.790244432520066 0.209056761429575 no 2673 0.214692515835543 863 1377 SGTC_3199 9111318 49.47 µM -0.791049444483776 0.208817714855285 no 2674 0.214457569458561 842 8548020 SGTC_934 2950-0684 338 µM -0.791186555612682 0.208777016057941 no 2675 0.214417567861557 871 1121253 SGTC_349 k015-0014 24 µM -0.795765703604459 0.207420471024485 no 2676 0.21308411473694 875 2196908 SGTC_2416 tofa 880 nM -0.796635907677501 0.207163268741201 no 2677 0.212831258436567 868 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_1762 st045503 25.4615 µM -0.797549101180947 0.206893563226258 no 2678 0.212566099071088 865 4645554 SGTC_23 0213-0011 39.996 µM -0.797911422928518 0.206786611564253 no 2679 0.212460947031193 883 627608 SGTC_1517 deoxycholic acid methyl ester 49.2 µM -0.798402069983404 0.20664183248096 no 2680 0.212318601217127 899 229346 A bile salt which induces apoptosis. SGTC_2881 9058953 51.95 µM -0.80043035711284 0.206043967174413 no 2681 0.211730749225711 839 17122249 SGTC_3234 9132280 49.47 µM -0.801593985282794 0.205701435445759 no 2682 0.211393929000046 861 17612295 SGTC_2688 kanamycin b 96.69 µM -0.802178291541488 0.205529563505235 no 2683 0.211224915932758 853 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis. SGTC_2340 7987427 183.45 µM -0.803005560333678 0.205286370729457 no 2684 0.210985760372519 856 2239331 SGTC_2847 9005661 71.43 µM -0.803395802004562 0.205171710480981 no 2685 0.210873000333355 838 2991449 SGTC_2522 biochanin a 4.94 µM -0.803999072709313 0.204994533251644 no 2686 0.210698755272871 866 5280373 A possible chelator. SGTC_2634 4'-methoxyflavone 100 µM -0.805339643057802 0.204601141012478 no 2687 0.210311855572129 880 77793 From seeds of Psoralea corylifolia (Fabaceae) SGTC_2470 5664817 21.68 µM -0.806590962841344 0.204234345105322 no 2688 0.209951091029413 874 2859561 SGTC_2275 7947463 200 µM -0.808519585457936 0.203669780778652 no 2689 0.209395767983324 855 1225414 SGTC_1685 st024049 53.0905 µM -0.80986272666895 0.20327715426429 no 2690 0.209009538150433 872 1941139 SGTC_2502 avocadyne acetate 18.59 µM -0.811299310178731 0.202857713067668 no 2691 0.208596903055708 854 3952079 SGTC_278 4092-0821 23.9 µM -0.81130686579973 0.202855508410574 no 2692 0.208594734097626 878 877900 SGTC_1846 st056244 14.8 µM -0.811779994489838 0.202717482549219 no 2693 0.208458941661125 890 5393182 SGTC_3338 9144300 39.5675 µM -0.812264036054378 0.202576331166201 no 2694 0.208320071088522 871 4901274 SGTC_291 SEC14.278 35.5 µM -0.812923392620781 0.202384150714986 no 2695 0.208130990815768 868 1068044 SGTC_274 sirtinol 40.1 µM -0.813219238518642 0.202297956947946 no 2696 0.208046185545786 861 6836442 NAD-dependent acetyltransferase inhibitor. SGTC_2347 9049783 174.81 µM -0.814070876943799 0.202049957391572 no 2697 0.207802174286283 900 6467988 YPL169C MEX67 SGTC_1362 1611-0397 101 µM -0.814649350625404 0.201881608008137 no 2698 0.207636526574343 881 27816 SGTC_1421 4029-0249 71.4 µM -0.815449585517459 0.201648859410454 no 2699 0.20740750551998 878 2894095 SGTC_2130 NSC 7 2.4545 µM -0.815576309462948 0.201612016454478 no 2700 0.207371251805449 865 21448 SGTC_857 0438-0306 1.35 µM -0.816966594665018 0.201208078181337 no 2701 0.206973759298046 861 4686136 SGTC_2536 dehydroabietamide 32.04 µM -0.817552065361198 0.201038118805731 no 2702 0.206806504031367 879 3983547 SGTC_2748 diazoxide 86.69 µM -0.817563876473355 0.201034690982087 no 2703 0.206803130696785 815 3019 A potassium channel activatior. SGTC_1679 SEC14.276 6.7 µM -0.817744475426866 0.200982281879444 no 2704 0.206751554454941 871 1005053 YMR079W SEC14 SGTC_1582 3',3',6'-trihydroxyflavone 74 µM -0.818084126817148 0.200883738594024 no 2705 0.206654575952258 873 688803 SGTC_2264 7948757 110.76 µM -0.819009327531277 0.20061545657787 no 2706 0.206390545938552 867 2971411 SGTC_2981 9013952 38.96 µM -0.819485260972055 0.200477533186173 no 2707 0.206254803885876 858 2996344 SGTC_1422 4031-0024 15.5 µM -0.820617261379207 0.200149713405144 no 2708 0.205932156180591 903 782427 SGTC_1371 2421-0008 32.7 µM -0.822859779880477 0.199501247054174 no 2709 0.205293868466133 874 2827552 SGTC_2531 methyl deoxycholate 70.07 µM -0.823701465449983 0.199258184624744 no 2710 0.205054603286021 902 16667744 Haematoxylin. SGTC_87 0100-0052 35.5 µM -0.823812831210862 0.199226037723176 no 2711 0.205022957864635 893 200187 YGR083C | YDR527W GCD2 | RBA50 SGTC_1689 st020265 53.493 µM -0.823966019154882 0.199181823511179 no 2712 0.204979433097571 880 5758320 YPR016C TIF6 SGTC_2737 bleomycin 30.5 nM -0.824315074878042 0.199081098604738 no 2713 0.204880277608054 876 16211318 Bleomycin acts by induction of DNA strand breaks. SGTC_1346 1488-2224 62.4 µM -0.824990945124558 0.198886154059479 no 2714 0.204688365733138 864 3722427 SGTC_1589 2',5'-dimethoxyflavone 47.2 µM -0.826355376085307 0.198492955362768 no 2715 0.204301264555353 859 688667 SGTC_2219 9098279 200 µM -0.826479380302855 0.198457243363661 no 2716 0.204266105078185 850 902349 SGTC_26 0302-0163 425.158 µM -0.826663336888821 0.198404272811411 no 2717 0.204213953672024 911 3100915 SGTC_729 4092-0585 94.1 µM -0.826670183528085 0.198402301476888 no 2718 0.204212012813499 878 2169061 SGTC_1071 trifluoperazine 6.31 µM -0.826937386886184 0.198325375560542 no 2719 0.204136275630741 901 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. SGTC_765 1319-0117 244 µM -0.828126505859342 0.197983255152219 no 2720 0.203799429971733 856 3487746 YGL099W LSG1 SGTC_2742 clothiapine 36.27 µM -0.828286697130894 0.197937193916563 no 2721 0.203754077398003 858 16351 An atypical antipsychotic. YIL048W NEO1 SGTC_2462 5162487 171.77 µM -0.833225226809915 0.196520351876647 no 2722 0.202358858849182 867 2259986 SGTC_2916 7875993 68.79 µM -0.833341863729191 0.196486963720908 no 2723 0.202325976152296 870 1299250 SGTC_2071 5230951 39.92 µM -0.834168731004465 0.196250365602544 no 2724 0.202092954424184 886 1799272 SGTC_1252 0493-0875 34.8 µM -0.835634562842865 0.195831360222713 no 2725 0.201680259256464 870 3960963 SGTC_3182 9108849 49.47 µM -0.836050602131247 0.195712535127645 no 2726 0.201563218203616 871 17133045 SGTC_2077 5212015 200 µM -0.837993447369126 0.195158218207974 no 2727 0.201017191828945 865 780900 SGTC_1399 3562-5772 25 µM -0.838754941956952 0.194941215265964 no 2728 0.200803420074133 886 23847490 SGTC_121 0557-0495 61.343 µM -0.838979754904252 0.19487717843316 no 2729 0.200740335204103 898 3104427 SGTC_2192 5915882 198.485 µM -0.839316553030808 0.194781267129313 no 2730 0.200645848382285 865 2876149 SGTC_3173 9105693 49.47 µM -0.839929313409887 0.194606842645963 no 2731 0.200474010396813 902 17096658 SGTC_500 h-89 112 µM -0.839941456488114 0.19460338703503 no 2732 0.200470605975219 890 449241 Protein kinase A inhibitor; also known to inhibit several other kinases. SGTC_2995 9067767 71.4286 µM -0.84049952667301 0.194444614760134 no 2733 0.20031418343143 885 11673567 SGTC_2204 7233102 200 µM -0.841216502927862 0.194240749104235 no 2734 0.200113328465979 867 2172480 SGTC_2827 7993847 71.43 µM -0.841643867099269 0.194119293943986 no 2735 0.199993663534848 845 2985692 SGTC_3125 9127534 49.47 µM -0.841927911752464 0.194038595206062 no 2736 0.199914152868596 852 1639235 SGTC_3183 9108214 49.47 µM -0.842732183508004 0.19381020782056 no 2737 0.199689121744744 875 4974831 SGTC_1670 st016595 4.04 µM -0.843415529468793 0.193616288300112 no 2738 0.19949804484568 900 597879 SGTC_325 2810-4341 181 µM -0.843835518412446 0.193497162812812 no 2739 0.199380662345047 862 774970 SGTC_482 fipronil 114 µM -0.846679570780711 0.192691654034528 no 2740 0.198586874350219 874 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels. SGTC_2420 aureobasidin a 50 nM -0.847567866080846 0.192440486506933 no 2741 0.198339338259304 874 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1 SGTC_2891 9063876 19.48 µM -0.850632788144711 0.191575410704132 no 2742 0.197486684892744 868 6472478 SGTC_1662 st014054 52 µM -0.85066770572001 0.191565568944845 no 2743 0.19747698370003 897 2838777 SGTC_879 0831-1030 162 µM -0.850987358032703 0.191475487133429 no 2744 0.197388187700079 895 1549252 SGTC_2944 9067346 25.62 µM -0.851507044169791 0.191329088828388 no 2745 0.197243875990229 882 6473075 SGTC_2915 7971052 15.16 µM -0.852571244750083 0.191029512111501 no 2746 0.196948557243779 846 5741558 SGTC_1982 st072467 71.9 µM -0.853261480672716 0.19083536183105 no 2747 0.196757157956266 903 3163533 SGTC_3090 9117696 49.47 µM -0.853711231432599 0.19070892063653 no 2748 0.196632504748114 862 7923821 SGTC_2694 st077685 81.9 µM -0.854185089119886 0.190575757750712 no 2749 0.196501221817113 894 2838096 SGTC_1424 4048-1941 275 µM -0.85596989835028 0.19007470553036 no 2750 0.196007214916601 886 X1424 SGTC_1294 1000-1494 117 µM -0.857251162505093 0.189715513975835 no 2751 0.19565304629262 880 712797 YDL207W GLE1 SGTC_355 1311-2252 105 µM -0.858213137622204 0.189446106982279 no 2752 0.195387391466347 905 5338538 SGTC_3203 9113543 49.47 µM -0.860448095676592 0.188821102875132 no 2753 0.19477104170471 897 17018012 SGTC_2845 9003024 42.97 µM -0.865347905787698 0.187455328357193 no 2754 0.193423932208598 877 2990173 SGTC_2107 5363541 170.161 µM -0.866316113691334 0.187186174019625 no 2755 0.193158416033184 883 244052 SGTC_1712 st032288 53.4 µM -0.869262648852713 0.186368531381794 no 2756 0.19235174381717 894 2883011 SGTC_574 1315-0397 40 µM -0.870588795630922 0.186001258149094 no 2757 0.191989358185762 905 6794277 SGTC_910 3454-3003 490 µM -0.870797454658316 0.185943511406102 no 2758 0.191932377652995 922 820824 SGTC_2940 9060638 45.86 µM -0.87135646810091 0.185788858273082 no 2759 0.191779773482545 876 4027022 SGTC_19 0279-0214 38.434 µM -0.872093187285686 0.185585164090302 no 2760 0.191578771219161 903 3566274 YBR002C RER2 SGTC_2054 5233173 129 µM -0.87227074781309 0.185536091427476 no 2761 0.191530345923033 809 6889 SGTC_1024 4507-0395 26 µM -0.874048239550479 0.185045287341263 no 2762 0.191045991848584 888 4201836 SGTC_3283 9109332 35.8195 µM -0.877061971838341 0.184214975567198 no 2763 0.190226489258061 865 17027281 SGTC_882 0843-0131 351 µM -0.878041868204553 0.183945505134576 no 2764 0.189960499025413 895 5425421 SGTC_666 0272-0154 136 µM -0.878383465223344 0.183851624055613 no 2765 0.18986782720343 893 6870312 SGTC_682 0kpi-0099 17 µM -0.879044561619812 0.183670019773547 no 2766 0.189688557397364 907 1714895 YML126C ERG13 SGTC_723 4182-0001 115 µM -0.880350245896844 0.183311674631391 no 2767 0.189334800402514 902 744821 YLR208W SEC13 SGTC_1836 st055642 81 µM -0.881098179329729 0.183106600771302 no 2768 0.189132341306172 901 8571 SGTC_2670 beta-carotene 100 µM -0.88261805946659 0.182690310037558 no 2769 0.188721333861691 849 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.) SGTC_2506 ethyl hematommate 54.16 µM -0.883586181536917 0.18242545256031 no 2770 0.188459820607983 910 3940691 An allergen. SGTC_213 1246-0773 967 nM -0.885565695216167 0.181884647128016 no 2771 0.187925802038385 902 6251622 SGTC_2324 6149169 200 µM -0.88657753607033 0.181608598707252 no 2772 0.187653196296527 899 2888231 SGTC_1638 st008370 60.6 µM -0.887605089194943 0.181328532173078 no 2773 0.187376607585023 874 24207134 SGTC_3101 9120531 49.47 µM -0.887658764021148 0.18131391017337 no 2774 0.187362166744294 916 24824904 SGTC_1521 st012942 49.4 µM -0.892375670654336 0.180031823316559 no 2775 0.1860958035563 879 24207259 SGTC_145 3737-0113 38.366 µM -0.893826027947392 0.179638753467445 no 2776 0.185707490407123 886 6849351 SGTC_973 1325-0077 65.9 µM -0.893876404558023 0.179625110304483 no 2777 0.185694011804179 907 2835149 SGTC_3041 9091929 49.47 µM -0.894121219908384 0.179558817860126 no 2778 0.185628518442928 895 25236887 SGTC_1487 3970-0795 2.82 µM -0.895350696086165 0.179226126118311 no 2779 0.185299823951161 890 3765103 SGTC_3136 9095672 49.47 µM -0.896124850454089 0.179016841829919 no 2780 0.185093043071944 854 17217380 SGTC_183 3914-0051 30.55 µM -0.896140587377259 0.179012589117664 no 2781 0.185088841140499 886 1596232 SGTC_3000 9075062 71.4286 µM -0.896909012223121 0.178805008979889 no 2782 0.184883735355885 871 17057871 SGTC_2212 7123476 200 µM -0.897708079870024 0.178589311857271 no 2783 0.184670600358637 889 1085715 SGTC_1035 k081-0041 55.2 µM -0.898258267927109 0.178440891594326 no 2784 0.184523937757871 879 731709 SGTC_1668 st014914 51.6 µM -0.89978015773601 0.178030747256322 no 2785 0.184118627917451 903 2839556 SGTC_1291 0993-0025 5.79 µM -0.901608730808501 0.17753873958255 no 2786 0.18363237572715 913 4353356 SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM -0.902198072215313 0.177380350621563 no 2787 0.183475829359496 909 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W SGTC_1564 D-Arginine 115 µM -0.903307852434137 0.177082332938988 no 2788 0.18318126507127 923 71070 D-isomer of arginine; arginine decarboxylase inhibitor. SGTC_2389 9091542 195.52 µM -0.905604817638827 0.176466517052366 no 2789 0.182572528965329 892 3626624 YOL127W RPL25 SGTC_3096 9117468 49.47 µM -0.906599490739391 0.176200266235408 no 2790 0.182309315582826 890 41316311 SGTC_595 3909-8003 73.7 µM -0.906891330070721 0.1761221959124 no 2791 0.182232133197459 915 699517 SGTC_8 0354-0001 70 µM -0.907378960292122 0.175991798178953 no 2792 0.182103215814782 899 4993152 SGTC_81 0411-0046 9.971 µM -0.908122987009279 0.175792955003676 no 2793 0.181906623426144 888 12925265 SGTC_414 piperonyl butoxide 100 µM -0.908580474737943 0.175670760839143 no 2794 0.181785808469207 906 5794 A potent inhibitor of cytochrome P450. SGTC_2279 7948423 32.93 µM -0.908720713869597 0.175633313994302 no 2795 0.181748783683804 893 1247112 SGTC_3164 9100705 49.47 µM -0.909118368004011 0.17552715935081 no 2796 0.181643823957437 870 17174235 SGTC_3313 9133968 57.047 µM -0.909381589478199 0.175456914173107 no 2797 0.181574368233122 903 1494643 SGTC_824 1304-0008 100 µM -0.909460496862511 0.175435859852517 no 2798 0.181553550337898 908 768245 SGTC_3322 9139058 2.11 µM -0.909650247550133 0.175385236523908 no 2799 0.181503495106733 894 4908926 YPR165W RHO1 SGTC_1930 st074634 34.3 µM -0.91136302084355 0.174928707206428 no 2800 0.181052065511593 920 684253 YOR116C RPO31 SGTC_2914 7968218 45.32 µM -0.91265863818587 0.174583869705747 no 2801 0.180711051982515 877 2977111 SGTC_488 nitrendipine 139 µM -0.916763918383023 0.173494074357039 no 2802 0.179633181855984 920 4507 Dihydropyridine L-type calcium channel blocker. SGTC_2953 9074162 66.49 µM -0.917261117725318 0.173362381453041 no 2803 0.179502913509995 857 16451992 SGTC_74 000s-0487 160.283 µM -0.919862719062128 0.172674334860087 no 2804 0.178822251507983 900 677548 SGTC_1402 3909-7673 35.9 µM -0.922016004924743 0.172106173074302 no 2805 0.178260113690954 888 5328014 SGTC_908 3448-7491 47.7 µM -0.923178099000692 0.171800041523069 no 2806 0.177957200067796 856 1203031 SGTC_2505 galangin 7.89 µM -0.925134949893087 0.171285332807319 no 2807 0.17744785762028 913 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_302 1094-0063 18.9 µM -0.925606988747597 0.171161320599903 no 2808 0.177325130046567 915 5440289 SGTC_2235 salicylic acid 500 µM -0.925996858245993 0.171058938911563 no 2809 0.177223806489807 914 338 A COX inhibitor and kinase inhibitor. SGTC_1183 1254-0324 198 µM -0.927556704715634 0.170649707371155 no 2810 0.176818782406761 887 5799357 SGTC_632 0781-2353 4.65 µM -0.927630800731026 0.170630283610293 no 2811 0.176799557471668 934 6811515 YHR007C ERG11 SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM -0.928431380881077 0.170420507296061 no 2812 0.176591923399334 869 279621 SGTC_939 1165-0479 45.3 µM -0.928433360706059 0.170419988726614 no 2813 0.176591410114019 900 1377347 SGTC_16 erodoxin 22.806 µM -0.929746392648637 0.170076292921035 no 2814 0.176251203997347 900 3967339 Erodoxin inhibits Ero1. YML130C ERO1 SGTC_2948 9070189 9.45 µM -0.930812592626831 0.169797534264166 no 2815 0.175975257312242 857 6473636 YDL196W YDL196W SGTC_430 0958-0115 16.4 µM -0.931100248741591 0.169722376606684 no 2816 0.175900854982249 911 6833180 SGTC_2551 apiole 73.87 µM -0.93509036357737 0.168682056329861 no 2817 0.174870866142287 886 10659 A possible DNA adduct former. SGTC_471 1-acyl-paf 4 µM -0.935537778020057 0.168565660548928 no 2818 0.174755611888531 894 16759367 SGTC_335 4077-0256 27.6 µM -0.936066820208681 0.168428095782222 no 2819 0.174619392508555 900 3121989 SGTC_2918 7977171 22.06 µM -0.941788911218488 0.16694481794778 no 2820 0.173150361748412 903 2236483 SGTC_161 4065-0411 162.148 µM -0.942314530639347 0.166808990891947 no 2821 0.173015815477784 922 1906281 YLR208W SEC13 SGTC_2331 7980721 200 µM -0.943690241282821 0.166453826548788 no 2822 0.172663981146057 901 2981221 SGTC_2191 5911152 200 µM -0.944248295626464 0.166309894116046 no 2823 0.172521390369813 904 2875902 SGTC_1051 3253-3903 78 µM -0.94440052564248 0.166270645164866 no 2824 0.172482506488185 899 5509239 SGTC_2843 9000894 45.46 µM -0.94851894066521 0.165211078677466 no 2825 0.171432667543882 867 2242070 SGTC_2400 5203494 178.7 µM -0.949110473377674 0.165059251622137 no 2826 0.171282214087362 909 6777674 SGTC_3004 9076122 71.4286 µM -0.952532209413837 0.164182777370402 no 2827 0.170413569438053 940 44782551 SGTC_390 dec-rvkr-cmk 16.7 µM -0.952991998048543 0.164065233440924 no 2828 0.170297062532435 912 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1 SGTC_2220 6782180 200 µM -0.953199902405921 0.16401210108742 no 2829 0.170244397923375 897 833803 SGTC_547 1120-0019 610 nM -0.953641644394919 0.163899245895672 no 2830 0.170132534146087 876 3676939 SGTC_2443 5493264 126.67 µM -0.955312389550476 0.163472863733007 no 2831 0.169709871947415 930 5340055 SGTC_165 k038-0023 64.381 µM -0.955494565688052 0.163426415108205 no 2832 0.169663826100505 932 46368543 SGTC_1970 st070122 35.8 µM -0.956591680374573 0.163146870026697 no 2833 0.169386694846164 915 102928 SGTC_656 4090-1979 187 µM -0.958925775679783 0.162553176463159 no 2834 0.168798069319733 905 22330961 SGTC_1680 diphenhydramine 100 µM -0.959913533959967 0.162302357039692 no 2835 0.168549367059573 887 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1 SGTC_1398 3558-0053 112 µM -0.96146655415594 0.161908511556491 no 2836 0.168158817214164 900 4532369 SGTC_1312 1218-2183 165 µM -0.9623977352628 0.161672663127912 no 2837 0.167924925434964 903 6744073 SGTC_368 fentichlor 4.58 µM -0.962839351604769 0.161560889393774 no 2838 0.167814074570263 954 7329 A pesticide. SGTC_1585 2',4'-dihydroxychalcone 10.4 µM -0.963884660445581 0.161296521017984 no 2839 0.167551877617784 923 5357218 A potent inhibitor of glutathione S-transferases. SGTC_1320 1313-0481 95.3 µM -0.965291064155001 0.160941273850035 no 2840 0.16719952312399 919 6813365 YLR208W SEC13 SGTC_2061 5245884 80.95 µM -0.966186946291181 0.160715247132775 no 2841 0.166975321801054 932 573863 SGTC_1709 st033179 39.1045 µM -0.969028297491346 0.159999759970882 no 2842 0.166265535327663 922 573381 SGTC_2384 9036245 200 µM -0.970322835034035 0.159674471272727 no 2843 0.165942799243873 893 6462766 SGTC_1630 st005209 31.3 µM -0.970331453943017 0.159672306982446 no 2844 0.165940651855074 888 3367314 SGTC_1462 k081-0014 26.5 µM -0.973579859027786 0.158857968510712 no 2845 0.165132595376652 858 3270634 SGTC_1807 st050092 58.9 µM -0.974122117100172 0.158722296126701 no 2846 0.164997954558142 925 5008496 SGTC_2873 9040596 71.43 µM -0.974701279433369 0.158577474255995 no 2847 0.164854229063409 923 6463863 SGTC_461 N-acetylfarnesylcysteine 136 µM -0.975228476371933 0.15844572190508 no 2848 0.164723469873596 967 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ). SGTC_1938 st074717 56.4 µM -0.975406689888125 0.158401200617977 no 2849 0.164679283271049 869 17250979 SGTC_2663 amphotericin b 100 µM -0.977739432752448 0.157819191803053 no 2850 0.16410160676525 916 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_2963 9082507 9 µM -0.978190300774157 0.157706864428592 no 2851 0.163990106330722 930 16459611 SGTC_3139 9095020 49.47 µM -0.980055541792691 0.157242724264092 no 2852 0.16352935145921 854 25236292 SGTC_3170 9103054 49.47 µM -0.980849949716756 0.157045319517869 no 2853 0.163333371038474 921 16432970 SGTC_651 3253-0966 34.4 µM -0.98306411879767 0.156495974857269 no 2854 0.16278794122618 926 781462 SGTC_2541 muurolladie-3-one 83.07 µM -0.985697979480922 0.155844152686562 no 2855 0.162140670641068 911 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils.  YMR203W TOM40 SGTC_2489 cantharidin 73.42 µM -0.986487572977616 0.155649095016235 no 2856 0.161946955209172 910 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_1350 1495-0454 146 µM -0.986611265906987 0.155618553058584 no 2857 0.161916622589006 909 1069057 SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM -0.986794180770174 0.155573395410207 no 2858 0.161871774043816 928 7104 SGTC_1802 st050112 57.9 µM -0.987781458036905 0.155329807662778 no 2859 0.1616298451719 919 4662563 SGTC_2263 7948595 193.29 µM -0.98784914103073 0.155313117679453 no 2860 0.16161326832622 909 2971371 SGTC_1508 1080-0625 72.9 µM -0.988581717168884 0.15513254709691 no 2861 0.161433917488025 905 767111 SGTC_2341 7987486 176.74 µM -0.989531772287119 0.154898577255404 no 2862 0.161201516367632 898 1258686 SGTC_3047 9092122 49.47 µM -0.99039462350688 0.154686285165788 no 2863 0.160990636172441 937 17173831 SGTC_2127 5253358 187.912 µM -0.990437206335511 0.154675813255856 no 2864 0.1609802336251 929 20612 SGTC_1373 2887-0003 58.5 µM -0.992053355041845 0.154278718494051 no 2865 0.160585749413676 940 776948 SGTC_1526 st051518 75 µM -0.993516940087043 0.153919691500213 no 2866 0.16022904962277 934 673993 SGTC_15 0266-0086 27.098 µM -0.994711290013961 0.153627119661653 no 2867 0.159938350918186 945 1712902 YIL048W NEO1 SGTC_454 lyso-paf C-16 6.67 µM -0.995842590075743 0.153350332525291 no 2868 0.159663316534855 920 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_1702 st027038 51 µM -0.999250235002734 0.152518605738062 no 2869 0.158836743122683 932 5521182 SGTC_3200 9114385 49.47 µM -1.00004757408129 0.152324426781948 no 2870 0.158643742670363 912 17018030 YLR208W SEC13 SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM -1.00134686663534 0.152008356961814 no 2871 0.158329571109272 926 5355888 SGTC_1519 esterone 74 µM -1.00151961619393 0.15196636621657 no 2872 0.158287830683351 936 698 A steroid. SGTC_299 1273-0059 1.44 µM -1.0018634435928 0.151882814006956 no 2873 0.1582047752472 901 2848077 SGTC_3215 9129942 49.47 µM -1.0024562223465 0.151738836739655 no 2874 0.158061649938065 949 17682944 SGTC_1215 3852-0577 11.2 µM -1.00300630843301 0.15160531005822 no 2875 0.15792890875259 916 2884876 SGTC_2138 5575593 77.673 µM -1.00421326453654 0.151312609969978 no 2876 0.157637914936133 930 762213 SGTC_3105 9121040 49.47 µM -1.0057672672311 0.150936301130955 no 2877 0.157263768217829 876 41448907 SGTC_581 0958-0271 211 µM -1.00822087227673 0.150343418660466 no 2878 0.156674219940932 929 4591145 SGTC_1907 st060210 83.7 µM -1.00892300506192 0.150174043159274 no 2879 0.15650578066102 933 688793 SGTC_2311 7694451 200 µM -1.01128867376133 0.149604309373834 no 2880 0.155939142703298 938 2163142 SGTC_3033 9090887 49.47 µM -1.01164520042793 0.149518570809613 no 2881 0.155853862885602 937 19325384 SGTC_2184 6075246 200 µM -1.01331064272643 0.149118494885297 no 2882 0.15545590280083 914 2267320 SGTC_2899 9053889 58.44 µM -1.01522963328931 0.148658398424532 no 2883 0.154998189003079 918 6470052 SGTC_3094 9117742 49.47 µM -1.01616365172633 0.148434802230416 no 2884 0.154775731116248 940 17149698 SGTC_1745 st081495 74 µM -1.01772771308721 0.148060882939432 no 2885 0.154403686656184 914 13842402 YBL026W LSM2 SGTC_402 epigallocatechin gallate 10 µM -1.01782411896067 0.148037855883931 no 2886 0.154380773879541 927 65064 An antioxidant. SGTC_146 3448-8650 53.125 µM -1.01824033909499 0.147938467005504 no 2887 0.154281876677569 963 2891488 YIL048W NEO1 SGTC_334 1502-1024 68.5 µM -1.01947897076259 0.147642959429224 no 2888 0.153987815884111 936 3296216 SGTC_2659 sanguinarine 24.21 µM -1.01983258981712 0.147558667068292 no 2889 0.153903932065605 911 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis. SGTC_2091 4-phenylthiadiazole 200 µM -1.01997314112056 0.147525172734799 no 2890 0.15387059955849 935 270010 SGTC_1344 1488-0097 29.1 µM -1.02010702003021 0.147493273215065 no 2891 0.153838853889193 940 747966 SGTC_2975 9084847 53.72 µM -1.02227653046499 0.146976985082388 no 2892 0.153325019008906 935 27211724 SGTC_3104 9120930 49.47 µM -1.02552571644191 0.146206031062383 no 2893 0.152557598802793 938 17014836 SGTC_1178 0988-0033 191 µM -1.02649915002378 0.14597558827897 no 2894 0.152328182032129 921 5392207 SGTC_2312 7706453 155.7 µM -1.02679268874621 0.14590614621697 no 2895 0.152259046410316 929 976098 SGTC_537 1334-0398 209 µM -1.02736343930853 0.145771188075806 no 2896 0.152124680189488 927 5846986 SGTC_2946 9065502 71.43 µM -1.02774676356616 0.145680595369849 no 2897 0.152034482123944 876 16489101 SGTC_199 4063-0024 41.6 µM -1.02797155682412 0.145627486602001 no 2898 0.151981603701273 936 306215 SGTC_298 1391-0729 10 µM -1.02944467661569 0.145279775330042 no 2899 0.151635382107183 935 3237558 SGTC_1981 st071826 47 µM -1.03753581541253 0.143379929109572 no 2900 0.149743106565044 911 11838600 SGTC_2418 pentamidine 31.67 µM -1.03884089568736 0.143075067037369 no 2901 0.149439369085967 894 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_2362 9071156 126 µM -1.03959563446011 0.142898962773236 no 2902 0.149263902986208 958 653133 SGTC_1125 tnp00248 1.32998 µM -1.04018504012318 0.142761537829734 no 2903 0.149126970200572 933 24207736 SGTC_663 1486-0733 13.9 µM -1.04035315647995 0.142722356452354 no 2904 0.149087928203767 931 722445 YPR165W RHO1 SGTC_2296 7971656 126.45 µM -1.04046297104753 0.142696766877838 no 2905 0.149062429434389 931 666570 SGTC_1510 1123-0200 71.5 µM -1.04236195672719 0.142254745745757 no 2906 0.148621948708508 946 5378812 YNL149C | YNL150W PGA2 | YNL150W SGTC_1931 st074438 57.1 µM -1.04682126173784 0.141220412323875 no 2907 0.147591011134758 959 2787313 SGTC_2808 7946468 45.46 µM -1.04863562302028 0.140801035107759 no 2908 0.147172926950507 952 2970879 SGTC_2747 doxorubicin 7.63 µM -1.05066887621694 0.140332067546732 no 2909 0.146705347673424 860 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_1835 st008666 49.2 µM -1.05175802301018 0.140081293840778 no 2910 0.146455291265558 929 690455 SGTC_1407 3909-7909 12.3 µM -1.05294072280521 0.139809324773224 no 2911 0.146184080313844 917 4411780 SGTC_1576 erythromycin ethylsuccinate 23.2 µM -1.05479731868774 0.139383113571702 no 2912 0.145759015591391 927 3256 An antibiotic and ribosome inhibitor. SGTC_57 miconazole 162.5 nM -1.05484310685669 0.139372613347779 no 2913 0.145748542970011 907 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_1611 st001856 99.4 µM -1.05677747489709 0.138929512191282 no 2914 0.14530657838364 959 647478 SGTC_2032 5185112 25.99 µM -1.05718550123507 0.138836169188934 no 2915 0.145213467762515 925 5718189 SGTC_3157 9099274 49.47 µM -1.0572988332668 0.138810250129091 no 2916 0.145187612793413 920 17217662 SGTC_2499 avocadenofuran 51.48 µM -1.06008974106534 0.138173008607986 no 2917 0.144551887267673 954 6857792 A insecticide and lysyl oxidase inhibitor. SGTC_2252 omeprazole 400 µM -1.06083325651333 0.138003580455357 no 2918 0.144382842814388 931 4594 A proton pump inhibitor. SGTC_2642 cholecalciferol 100 µM -1.06097308905088 0.137971732034026 no 2919 0.144351065608327 921 9821465 A vitamin D precursor, similar to steriods. SGTC_2376 9072922 81.32 µM -1.0624985023629 0.137624627769633 no 2920 0.144004718766567 953 17087968 SGTC_575 k072-0246 11.9 µM -1.06316875530454 0.137472301901273 no 2921 0.143852714441642 960 6796779 SGTC_1730 st033808 45.1 µM -1.06701921398616 0.136599452995446 no 2922 0.142981579832832 943 1045166 SGTC_2163 5671233 125 µM -1.0748027663384 0.13484661680546 no 2923 0.141231520839949 920 701023 SGTC_2911 7942208 15.64 µM -1.07515558636493 0.134767529887937 no 2924 0.141152538092659 908 1243384 SGTC_2315 7733312 200 µM -1.07705994645574 0.134341204660711 no 2925 0.140726742735326 928 726316 SGTC_859 0439-0102 54.6 µM -1.07865641919572 0.133984519893392 no 2926 0.140370460116153 942 610143 SGTC_1645 Cervolide 78 µM -1.07910497767731 0.133884419937259 no 2927 0.140270466259146 950 23173 A fragrance. SGTC_1468 k284-1086 134 µM -1.07993505972161 0.133699315077034 no 2928 0.140085549776015 943 15996457 SGTC_3240 9133527 49.47 µM -1.08070732696865 0.133527260739378 no 2929 0.139913661416137 945 17617455 SGTC_611 3453-1652 23.7 µM -1.08220279425605 0.13319451689259 no 2930 0.139581213580549 950 1560575 SGTC_412 gemfibrozil 100 µM -1.08236718182621 0.133157975236385 no 2931 0.13954470242148 937 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels. SGTC_744 1594-0068 283 µM -1.08369854895979 0.132862280306397 no 2932 0.139249239604205 964 668392 SGTC_1596 piperlongumine 63 µM -1.08389506908231 0.132818671764413 no 2933 0.139205663081461 941 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_2368 9071271 200 µM -1.08486461308951 0.132603670638464 no 2934 0.138990811489656 958 27209959 SGTC_3347 9188721 44.724 µM -1.08526922792881 0.132514016264928 no 2935 0.138901215374846 965 44118411 YKL104C | YBL026W GFA1 | LSM2 SGTC_1965 Pectolinarigenin 58.4 µM -1.08723870946729 0.132078215908531 no 2936 0.138465663779851 958 5320438 An anti-inflammatory. SGTC_3231 9132313 49.47 µM -1.0872674952346 0.132071853625801 no 2937 0.138459304705103 943 4905967 SGTC_2082 5219693 150 µM -1.08828514963925 0.131847065588602 no 2938 0.138234622166642 935 2834649 SGTC_2320 7373003 200 µM -1.08844192023501 0.131812460260407 no 2939 0.138200031723361 935 5415828 SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM -1.08891486536129 0.131708100964658 no 2940 0.138095715122202 931 4330530 SGTC_2393 9031399 185.94 µM -1.0900512091937 0.131457590304311 no 2941 0.137845293482642 967 1526623 YDL150W RPC53 SGTC_1367 1812-0510 76.9 µM -1.09285542910717 0.130840799074988 no 2942 0.137228640136027 940 1142582 YDR527W RBA50 SGTC_1703 st026983 48.3 µM -1.09333354849037 0.130735836102176 no 2943 0.137123689076173 936 1104023 SGTC_634 1611-4317 11.2 µM -1.09346371929897 0.130707269400292 no 2944 0.137095125033405 956 2843522 SGTC_2763 lisinopril 49.32 µM -1.09513913397298 0.130339975578696 no 2945 0.136727843136775 943 5362119 A lysine-analog of enalapril and an ACE inhibitor. SGTC_3084 9116877 49.47 µM -1.0959443571609 0.130163704297984 no 2946 0.136551562878495 933 27241325 SGTC_944 3370-0224 231 µM -1.09653069263529 0.130035453530644 no 2947 0.136423299573433 958 4580514 SGTC_1121 fusaric acid 630.51 nM -1.09708800025183 0.129913633207534 no 2948 0.136301462649737 948 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler. SGTC_1313 1220-0047 237 µM -1.09890286892061 0.129517473790446 no 2949 0.135905217575921 952 3528706 SGTC_407 eburnamonine 100 µM -1.10119513609915 0.129018302440019 no 2950 0.135405869075353 929 3195 SGTC_202 3594-0513 34.79 µM -1.10472789361437 0.128251613150067 no 2951 0.134638756519694 950 708429 SGTC_1303 1160-0052 261 µM -1.10639183587994 0.127891597747326 no 2952 0.134278478824449 920 3562476 SGTC_2508 celastrol 40.54 µM -1.1131470736723 0.12643723016219 no 2953 0.132822634594732 908 122724 Celastrol is a natural product and antioxidant. SGTC_2063 5246145 200 µM -1.11527547369104 0.125981393201449 no 2954 0.132366196107308 965 711240 SGTC_679 0422-0091 41.4 µM -1.11762086489374 0.125480412025625 no 2955 0.131864476828825 969 627384 YHR062C RPP1 SGTC_2823 7987624 58.44 µM -1.11772859678323 0.125457433683167 no 2956 0.13184146269133 959 2239440 SGTC_2215 7188065 200 µM -1.1178605634537 0.125429290259908 no 2957 0.131813275194647 970 940217 SGTC_596 1155-0152 116 µM -1.11825329150854 0.12534556251779 no 2958 0.131729414818949 948 280313 SGTC_176 1486-1328 72.834 µM -1.11998159846727 0.124977559442894 no 2959 0.131360801882013 944 22310231 SGTC_2730 imipramine 71.33 µM -1.12202577636425 0.124543274019211 no 2960 0.130925740182425 941 3696 A tricyclic antidepressant. SGTC_453 enantio-paf c16 10 µM -1.12284462895832 0.124369605152871 no 2961 0.130751743685428 957 13871343 A lipid and platelet activating factor SGTC_2518 prenyletin 46.28 µM -1.12422383459667 0.124077475079131 no 2962 0.130459040261715 946 3873459 A coumarin with calcium channel inhibitory activity. SGTC_187 1488-2104 32.728 µM -1.12425788070012 0.124070269838206 no 2963 0.130451820526319 959 2852859 SGTC_226 1,3-diallylurea 8.28947 mM -1.12802454097601 0.12327493168404 no 2964 0.129654777524983 953 74537 YKL182W FAS1 SGTC_95 0471-0001 561.058 µM -1.12909408201411 0.123049748525655 no 2965 0.129429073770362 956 4015405 SGTC_2902 5787006 60.46 µM -1.13069777804882 0.122712643958604 no 2966 0.129091158442095 947 591003 SGTC_2194 5927483 104.545 µM -1.13193575521403 0.12245285865944 no 2967 0.128830722564505 943 760979 SGTC_2189 6047310 154.431 µM -1.13314719076287 0.122199016882734 no 2968 0.128576223355123 953 711535 SGTC_2820 7989630 71.43 µM -1.14354744014947 0.12003496400484 no 2969 0.126405684884086 930 2984098 SGTC_3271 9137798 49.47 µM -1.14384835479828 0.119972755216871 no 2970 0.126343266135187 896 6498326 SGTC_2249 haloperidol 116.36 µM -1.14431320171301 0.119876701003183 no 2971 0.126246885125067 944 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_3250 9135583 49.47 µM -1.14796288937579 0.119124427025413 no 2972 0.12549194208543 967 7699353 SGTC_2463 5473429 200 µM -1.15134833119154 0.118429604517904 no 2973 0.124794480590501 947 5399405 SGTC_3177 9107506 49.47 µM -1.1519108826217 0.118314425506655 no 2974 0.124678847905715 955 8897194 SGTC_370 0180-0345 38.7 µM -1.15224209371993 0.11824664908386 no 2975 0.124610802359237 933 3989527 SGTC_774 k060-0086 136 µM -1.15656475897066 0.117364609395771 no 2976 0.123725113656471 978 5911235 SGTC_716 1683-5115 658 µM -1.15955398366048 0.116757389730194 no 2977 0.123115222705831 961 723597 SGTC_1081 sertraline 6 µM -1.16051460333546 0.11656272684081 no 2978 0.122919675801593 963 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1 SGTC_2581 avocatin a 64 µM -1.16127429423642 0.116408943841679 no 2979 0.122765184907632 986 6710728 A skin care supplement. SGTC_3318 9139014 38.6185 µM -1.16363483857499 0.11593202126192 no 2980 0.122286013315953 962 16643984 SGTC_1562 morin hydrate 59.1 µM -1.165671518724 0.115521648169792 no 2981 0.121873639854577 961 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase. SGTC_624 k048-0052 28 µM -1.16573726018204 0.115508419062939 no 2982 0.121860345255718 980 6835531 SGTC_827 3253-0474 693 µM -1.16698547099859 0.115257446704634 no 2983 0.121608118494043 965 5402065 SGTC_3217 9129673 49.47 µM -1.16705576702431 0.115243324125153 no 2984 0.121593924652616 982 17248312 SGTC_928 2764-0428 58.7 µM -1.1682569905776 0.115002186558533 no 2985 0.121351559199661 976 662578 SGTC_3327 9140648 26.9345 µM -1.16931566059396 0.114789963325363 no 2986 0.121138237907263 966 8029710 SGTC_978 1416-0512 87.4 µM -1.16959138213443 0.114734737362738 no 2987 0.121082723524074 983 6814003 SGTC_969 1313-0238 134 µM -1.17380639193197 0.113892839752101 no 2988 0.120236291584009 966 5212874 SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM -1.17433162824666 0.113788239354155 no 2989 0.120131109736265 958 6312947 SGTC_3216 9129716 49.47 µM -1.17530898006146 0.113593782784853 no 2990 0.119935561556543 946 8056934 SGTC_807 1315-0151 48 µM -1.17566910063028 0.113522191986178 no 2991 0.119863565372683 979 4011080 SGTC_1329 1447-1697 50.6 µM -1.17728519540154 0.113201313749695 no 2992 0.119540846961293 977 2840515 SGTC_3071 9117417 49.47 µM -1.18003410468703 0.112657000779831 no 2993 0.118993325427221 963 45595590 YGL055W OLE1 SGTC_2561 acetosyringone 100 µM -1.18136018812882 0.112395091661515 no 2994 0.118729833240373 973 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent. SGTC_2292 7671323 168.05 µM -1.18195354401793 0.11227804144302 no 2995 0.118612067268341 977 937504 SGTC_2628 lathosterol 100 µM -1.18212395162675 0.112244441556373 no 2996 0.118578260976554 974 6710616 SGTC_485 niflumic acid 177 µM -1.18655640945025 0.111373000872996 no 2997 0.11770131929946 993 4488 A COX2 inhibitor. SGTC_450 aminopyrene 156 nM -1.18696999478247 0.111291935875596 no 2998 0.117619728061387 964 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1 SGTC_3328 9140624 29.0385 µM -1.18788787823582 0.111112176594173 no 2999 0.117438793004169 978 4904392 SGTC_988 1497-1057 103 µM -1.18808987518721 0.111072645222782 no 3000 0.117399001425963 974 3533044 SGTC_1305 1181-0477 144 µM -1.18908007542139 0.110879005958109 no 3001 0.11720407902388 991 6252086 SGTC_1531 st059297 52.4 µM -1.19188474858817 0.110331849168337 no 3002 0.116653219565591 960 7566702 SGTC_831 k061-1017 217 µM -1.19603858646978 0.10952504875362 no 3003 0.115840750762245 1009 1240153 SGTC_1878 temozolomide 1 mM -1.19652523316159 0.109430805280666 no 3004 0.115745828843269 956 5394 DNA alkylating agent. SGTC_2460 5552655 174.22 µM -1.19889024832689 0.108973628310322 no 3005 0.115285312030319 970 5401989 SGTC_1308 1187-1617 41.4 µM -1.19956420025432 0.108843599556661 no 3006 0.115154318584317 974 2882570 SGTC_2982 9019404 25.97 µM -1.20387477202072 0.108014578341131 no 3007 0.114318991986339 959 22333232 SGTC_151 3013-0144 2.285 µM -1.2038905456083 0.108011553092794 no 3008 0.114315943236531 969 906558 YHR107C CDC12 SGTC_737 1950-0117 57.9 µM -1.20808942162143 0.107208410514313 no 3009 0.113506434121723 971 5393513 SGTC_672 1441-0018 53.7 µM -1.20864128311909 0.107103173879881 no 3010 0.113400344400261 957 251141 SGTC_2650 prasterone 100 µM -1.20901360631051 0.107032216208822 no 3011 0.113328809042248 964 16759247 A steroid and weak partial agonist of the androgen receptor. SGTC_2137 5261020 140 µM -1.211314267607 0.106594506245748 no 3012 0.11288749132078 960 763655 SGTC_2617 dihydrotanshinone i 20.83 µM -1.21171428601668 0.106518533201204 no 3013 0.112810884308345 962 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12 SGTC_614 0462-0418 107 µM -1.21253917621224 0.106361990300858 no 3014 0.112653027845812 956 5188303 SGTC_3144 9087057 49.47 µM -1.21452726186059 0.105985385750046 no 3015 0.112273222992559 967 17249618 SGTC_1801 st050089 28.441 µM -1.21784830139497 0.105358429665504 no 3016 0.111640812654496 979 5008493 YIL048W | YNL267W NEO1 | PIK1 SGTC_3142 9086498 49.47 µM -1.21988155897714 0.104975911590956 no 3017 0.111254888755349 939 25236367 SGTC_2667 digitoxin 100 µM -1.22037923679119 0.104882436482774 no 3018 0.111160572336648 936 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_1718 roemerine 11.9335 µM -1.22068623252414 0.104824805826643 no 3019 0.11110242121086 909 235224 An aporphine alkaloid with mutagenic activity. SGTC_123 0083-0120 66.675 µM -1.22163359884719 0.10464710641235 no 3020 0.110923108448214 1006 16001701 SGTC_1028 k015-0029 4.8 µM -1.22178111049389 0.10461945699838 no 3021 0.110895206844435 996 4588309 SGTC_2119 5528445 120.635 µM -1.2220894703587 0.104561675472255 no 3022 0.110836897285857 986 791935 SGTC_2087 5276107 200 µM -1.22539955420459 0.103942876203907 no 3023 0.110212357411608 977 144405 SGTC_1513 0337-0559 19 µM -1.23035203645277 0.103022006997192 no 3024 0.109282653003021 978 775073 SGTC_2286 7945697 125 µM -1.23259545442458 0.102606819587942 no 3025 0.108863366843788 976 1245733 SGTC_136 0097-0015 404.482 µM -1.23492432508045 0.102177105597749 no 3026 0.108429334704934 982 4861337 SGTC_540 1187-0821 17.3 µM -1.23594456230185 0.101989268410046 no 3027 0.10823958557963 973 847520 SGTC_389 tpck 16.7 µM -1.23653985399844 0.101879784640257 no 3028 0.108128980545149 998 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.  SGTC_949 1165-0505 146 µM -1.23691183749603 0.10181141430118 no 3029 0.108059907432098 986 6244267 SGTC_957 1187-1561 14.1 µM -1.23979476770973 0.101282665703048 no 3030 0.107525657006018 969 1538454 SGTC_1333 1482-0047 286 µM -1.24219671901558 0.100843662009948 no 3031 0.107081994962567 990 3811116 SGTC_2575 plumbagin 510 nM -1.24539072163371 0.100262046835509 no 3032 0.106494081103822 968 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_1515 3460-0031 42.1 µM -1.24589627187019 0.100170213042085 no 3033 0.1064012394843 965 2876596 SGTC_558 k064-0027 21.3 µM -1.24628786220145 0.100099122412681 no 3034 0.106329366175396 966 5088526 SGTC_2030 5175110 200 µM -1.24721871058826 0.0999302809262494 no 3035 0.106158657061031 1004 2831986 SGTC_1041 0206-0046 107 µM -1.24848516576252 0.0997008996889023 no 3036 0.105926718769933 994 50494 SGTC_1805 st050013 60.3 µM -1.25342269239206 0.0988102848652968 no 3037 0.105025958657012 968 4037144 SGTC_764 1951-2361 146 µM -1.2575467127844 0.0980708809066431 no 3038 0.104277867569094 971 5438930 SGTC_3128 9127691 49.47 µM -1.25961240454773 0.0977020463574616 no 3039 0.103904609236154 984 41316314 SGTC_3126 9127922 49.47 µM -1.26099406722008 0.0974559152113937 no 3040 0.103655492332628 974 45595682 SGTC_1430 4049-0248 69.1 µM -1.26940156071215 0.0959679916200547 no 3041 0.102148939916336 988 22774488 SGTC_913 3487-1245 167 µM -1.26993254370938 0.0958745843960718 no 3042 0.10205432981378 970 4016153 SGTC_3011 9081274 71.4286 µM -1.27000715854099 0.0958614639796436 no 3043 0.102041040116982 990 6625322 SGTC_598 3937-0236 20.2 µM -1.27081568289553 0.0957193761739702 no 3044 0.101897114056871 987 1379313 SGTC_206 4546-0025 72.014 µM -1.27240212142936 0.0954410303012923 no 3045 0.101615140358475 993 6620745 YIL048W NEO1 SGTC_103 0844-0104 51.839 µM -1.27357868665494 0.0952349831549657 no 3046 0.101406384826224 977 5375804 SGTC_2255 7941087 197.44 µM -1.2753688588637 0.0949221060913211 no 3047 0.10108935782372 1011 935561 SGTC_2647 atorvastatin 60.16 µM -1.27609998003979 0.0947945425349567 no 3048 0.100960089336228 958 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7 SGTC_2935 9038016 29.96 µM -1.27901719299242 0.0942868145995491 no 3049 0.100445500764695 972 6463195 SGTC_1734 st037168 69.4 µM -1.2799657747187 0.09412215107563 no 3050 0.10027858651404 997 708907 SGTC_1939 st074455 53.6 µM -1.28092270178281 0.093956253956067 no 3051 0.100110409018447 996 1644229 SGTC_655 k060-0012 42 µM -1.2826786074647 0.0936524037938137 no 3052 0.0998023488391703 1003 5994525 SGTC_3334 9142812 21.919 µM -1.28324618968897 0.0935543420362387 no 3053 0.0997029191408569 984 45283678 SGTC_801 0866-0028 10.1 µM -1.28545275677406 0.0931738315879192 no 3054 0.099317057814984 987 6849771 SGTC_2553 4-methylesculetin 85.09 µM -1.286255478025 0.0930356907745746 no 3055 0.0991769575145409 986 5319502 SGTC_2933 9026794 32.47 µM -1.28718581622327 0.0928757777490363 no 3056 0.0990147648926908 977 17586027 SGTC_1146 3579-1023 7 µM -1.2887607436315 0.0926055315903479 no 3057 0.0987406387404224 1000 X1146 SGTC_467 ro 31-8220 72.8 µM -1.29156628240667 0.0921255631646049 no 3058 0.0982536935283914 994 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7 SGTC_748 act1.228 77.9 µM -1.29481784334577 0.091571596807352 no 3059 0.0976915375481973 990 4421505 YNR035C ARC35 SGTC_2144 5628481 200 µM -1.29556482148019 0.0914446840187882 no 3060 0.0975627277218495 977 2818399 SGTC_1985 st071382 65.5 µM -1.29855597949553 0.090937787621107 no 3061 0.0970481766746657 1017 6123237 SGTC_3180 9109287 49.47 µM -1.29880542599829 0.0908956095397815 no 3062 0.0970053560376723 975 18891271 SGTC_2114 5491910 81.25 µM -1.30102704364904 0.0905206036596576 no 3063 0.0966245990359508 993 2849228 SGTC_365 0121-0052 13.6 µM -1.30109134972081 0.0905097660172161 no 3064 0.0966135941648102 956 3101739 SGTC_1045 1348-1485 165 µM -1.30188624319242 0.0903758804279443 no 3065 0.0964776379275482 993 6810614 SGTC_3261 9137475 49.47 µM -1.30352956184962 0.090099559185927 no 3066 0.0961970153423984 946 17027690 SGTC_783 0848-0141 92.7 µM -1.30593785199749 0.0896957439527097 no 3067 0.095786846491656 983 6755076 YHR007C | YLR033W ERG11 | RSC58 SGTC_2861 9024595 19.48 µM -1.30855385708223 0.0892586260085365 no 3068 0.0953427599473208 992 16482810 SGTC_2474 5321570 43.32 µM -1.3090232946597 0.0891803539630513 no 3069 0.0952632300482693 1006 2841384 SGTC_3127 9126946 49.47 µM -1.31087338857367 0.0888723743641207 no 3070 0.094950271445853 979 27243249 SGTC_140 0062-0056 502.533 µM -1.31239870613078 0.0886190554411481 no 3071 0.0946928216128565 997 3758964 SGTC_3069 9117009 49.47 µM -1.31242335150079 0.0886149668518607 no 3072 0.0946886660862268 986 41904981 SGTC_2626 ethyl orsellinate 100 µM -1.31556329394059 0.0880952088520387 no 3073 0.0941603301698572 994 75653 A natural product. SGTC_3336 9143619 71.43 µM -1.31778095247717 0.0877294892791589 no 3074 0.0937884929854567 1014 45595730 SGTC_55 0767-0285 6.563 µM -1.31807296913943 0.0876814166010184 no 3075 0.0937396111142601 982 3116166 SGTC_670 4204-0025 119 µM -1.32365469519976 0.086766310079257 no 3076 0.0928088756091514 1000 719039 SGTC_3179 9107801 49.47 µM -1.32589170436048 0.0864015694725756 no 3077 0.0924377855926079 978 4818259 SGTC_754 3474-0146 171 µM -1.33437872286423 0.0850281979853516 no 3078 0.0910398847776374 978 24762078 SGTC_195 4234-0266 16.654 µM -1.33725930093208 0.0845658008039783 no 3079 0.0905690054800829 1001 2303354 SGTC_1891 st059073 26.2 µM -1.33759089746602 0.084512693445388 no 3080 0.090514916661004 1000 688754 SGTC_2996 9066192 71.4286 µM -1.33860571163373 0.0843503197580216 no 3081 0.090349532874286 989 6472854 SGTC_2176 5809774 33.9695 µM -1.33876987927217 0.0843240743958451 no 3082 0.0903227996525368 959 2870539 SGTC_3230 9131665 49.47 µM -1.3406457741538 0.0840246113878568 no 3083 0.0900177440243112 971 15943720 SGTC_1038 k292-0204 154 µM -1.34183344326552 0.0838354282010376 no 3084 0.0898250029690598 999 4454212 SGTC_1948 st076329 66.6 µM -1.34246116202281 0.0837355685271007 no 3085 0.0897232575281639 1004 24208413 SGTC_2504 purpurogallin 52.29 µM -1.34461198578252 0.0833940855988441 no 3086 0.0893752853422437 997 5281571 An antioxidant. SGTC_2293 7624732 200 µM -1.34547111754377 0.0832579755393949 no 3087 0.0892365711836008 983 894453 SGTC_1678 st019265 80.2 µM -1.3486059584859 0.0827627470585771 no 3088 0.0887317828982316 993 5367020 SGTC_3233 9132340 49.47 µM -1.3512451590461 0.0823475389840243 no 3089 0.0883084564906879 1010 17682950 SGTC_14 0354-0009 295 µM -1.35189507133331 0.0822455336566171 no 3090 0.088204442230779 1007 1713507 SGTC_696 1560-0013 611 µM -1.35242073335917 0.0821630993492756 no 3091 0.0881203802452471 1002 1650269 SGTC_304 1310-0298 97 µM -1.35609326013529 0.0815889092688174 no 3092 0.0875347485252313 1006 1550234 SGTC_1482 3346-2049 8.48 µM -1.35621801023459 0.0815694581814993 no 3093 0.0875149066434644 1000 3826804 SGTC_1016 4226-1401 38 µM -1.36200604558789 0.0806708251105053 no 3094 0.0865979886006443 997 2901613 SGTC_2025 5147754 141 µM -1.36809420494828 0.0797336851712302 no 3095 0.0856412952108582 952 315777 YLR208W SEC13 SGTC_1126 isoteolin 1.0172 µM -1.36952859722206 0.0795140950461066 no 3096 0.0854170509850455 985 133323 SGTC_2863 9028737 58.44 µM -1.37308408378291 0.0789717614759999 no 3097 0.0848631042199118 998 6460917 SGTC_207 4185-0010 4.486 µM -1.37462724821289 0.0787372498068515 no 3098 0.0846235182588809 993 3761753 SGTC_144 4161-2749 112.381 µM -1.37488897253525 0.0786975284685575 no 3099 0.0845829342839163 994 797501 YMR168C CEP3 SGTC_3054 9094397 49.47 µM -1.37943478294466 0.0780100407344529 no 3100 0.0838803705520394 1015 2598354 SGTC_1737 st035557 69.7 µM -1.38166739654346 0.0776740634100641 no 3101 0.0835369247921896 981 5716916 SGTC_236 1509-0011 5.31 µM -1.38429849979607 0.077279530360906 no 3102 0.0831335366068142 1012 3107280 SGTC_865 0488-0499 301 µM -1.38598230756793 0.0770278439945058 no 3103 0.0828761529898644 986 9634651 SGTC_1436 4092-1007 8.32 µM -1.38678032873398 0.0769087779727908 no 3104 0.0827543786044769 992 2881121 SGTC_167 3672-0051 66.205 µM -1.38722462641641 0.0768425487128778 no 3105 0.0826866391813278 994 3237971 SGTC_1894 3',6'-dihydroxyflavone 78.7 µM -1.38855508746587 0.076644482782866 no 3106 0.0824840412821425 1009 688662 SGTC_1623 st003709 20.3 µM -1.38899084951961 0.0765796953028505 no 3107 0.0824177662894967 995 16192618 SGTC_3269 9137823 49.47 µM -1.39325934982301 0.0759472713099513 no 3108 0.0817706891700369 974 17682936 SGTC_2083 5306046 65.942 µM -1.39414574045746 0.0758164431278436 no 3109 0.081636799533108 999 539837 SGTC_2096 5468907 200 µM -1.39481032472412 0.0757184654394036 no 3110 0.0815365223006529 1016 759785 SGTC_142 0335-0849 62.6745 µM -1.39491646352619 0.0757028266463888 no 3111 0.081520515923513 969 3889043 YPR107C YTH1 SGTC_18 0111-0177 500 nM -1.39884081745573 0.0751263269172441 no 3112 0.0809303615682253 1022 721752 SGTC_3293 9120939 62.045 µM -1.39987657625988 0.0749747305524594 no 3113 0.0807751407542265 1006 934087 SGTC_2859 9028643 45.46 µM -1.40153782146412 0.0747320737428723 no 3114 0.080526652898973 968 17151580 SGTC_528 3492-0019 172 µM -1.40562413173759 0.0741377399385324 no 3115 0.0799178831772199 992 2869262 SGTC_3204 9114183 49.47 µM -1.40785568667773 0.0738146990361639 no 3116 0.0795869034958587 985 17027248 SGTC_768 0384-0033 77.3 µM -1.41278849921654 0.0731044413963449 no 3117 0.0788589604105386 985 3965305 YMR134W ERG29 SGTC_262 fenpropimorph 62.5 µM -1.41286886786448 0.0730929128596472 no 3118 0.0788471421815182 1040 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_1104 tacrolimus 29.8 µM -1.41438990213497 0.0728749892754539 no 3119 0.0786237266589483 981 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41 SGTC_1916 st067606 49.2 µM -1.41645315261354 0.0725801759947864 no 3120 0.0783214355424064 967 19590279 SGTC_1360 1598-0022 39.8 µM -1.41653988243866 0.0725678033987457 no 3121 0.0783087479047901 1018 761525 SGTC_1248 0469-0687 58.6 µM -1.41735003750272 0.0724523073148233 no 3122 0.0781903062291135 1004 4017482 SGTC_2840 9008771 71.43 µM -1.4199239238264 0.0720863071966004 no 3123 0.0778149150867331 995 2992978 SGTC_2034 5197015 53.07 µM -1.42305501985055 0.0716429860496958 no 3124 0.0773601031015673 1018 780676 SGTC_790 1575-0012 79.1 µM -1.43166835620756 0.0704342439281863 no 3125 0.0761193783070471 995 378741 YLR208W SEC13 SGTC_532 1548-0774 215 µM -1.43867927593158 0.0694620003552318 no 3126 0.0751207068336394 1037 5932993 SGTC_1828 st055811 49 µM -1.43925956773564 0.0693819934701783 no 3127 0.0750384969058491 1014 5877589 SGTC_710 3448-4187 58 µM -1.43933049150242 0.0693722198290671 no 3128 0.0750284538446435 997 3946412 SGTC_234 nsc-17383 10.7 µM -1.44281285040183 0.0688936369093257 no 3129 0.0745365991099482 985 408974 SGTC_2741 miltefosine 3.04 µM -1.4458643551558 0.0684763624553712 no 3130 0.0741076256730542 1000 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis. SGTC_125 0133-0007 11.75 µM -1.44633234302169 0.0684125408033459 no 3131 0.0740420041572403 1012 26541 SGTC_1861 st057647 17.4 µM -1.44990664245188 0.067926610014291 no 3132 0.0735422773865236 1013 688668 SGTC_295 k015-0027 31 µM -1.45110741452004 0.0677639629156213 no 3133 0.0733749761109734 1019 3887424 SGTC_864 0469-0573 172 µM -1.45181810352253 0.067667840404838 no 3134 0.0732760943952429 1040 689425 SGTC_2523 spermine 47.74 µM -1.45307052919538 0.0674987030452881 no 3135 0.0731020863071521 1002 1103 A DNA binding polyamine. SGTC_1265 0819-1001 68.8 µM -1.45513378020305 0.0672207781643661 no 3136 0.0728161144789498 1020 3106768 SGTC_2038 4100038 30.985 µM -1.45519288162752 0.0672128301147593 no 3137 0.0728079355080664 982 3596803 SGTC_3354 9151612 71.43 µM -1.45580327291353 0.0671307862622928 no 3138 0.0727235053752561 1000 27261949 SGTC_1672 st016598 6.51 µM -1.45735954942626 0.0669219546192726 no 3139 0.0725085784102737 1003 4665860 YNL267W PIK1 SGTC_1427 4048-4900 550 nM -1.45841809738013 0.0667801989396356 no 3140 0.0723626676794787 1021 24132586 SGTC_3197 9113331 49.47 µM -1.45911372662371 0.0666871701802168 no 3141 0.0722669043989071 998 16610459 YLR208W | YDL195W SEC13 | SEC31 SGTC_833 3852-0053 558 µM -1.46114610213846 0.0664159485076566 no 3142 0.0719876753048964 1044 3123681 SGTC_718 1130-0073 349 µM -1.4691227921612 0.065359702163241 no 3143 0.0708997433839439 1021 6740020 SGTC_1763 st044482 94.5 µM -1.47013237103079 0.0652269513299983 no 3144 0.0707629533072396 1009 88505 SGTC_1471 k673-0312 37 µM -1.47080911690583 0.0651380823190926 no 3145 0.0706713730956401 1014 24099884 SGTC_305 1682-2595 20.8 µM -1.47106826062693 0.0651040769361095 no 3146 0.0706363287606991 1008 226033 SGTC_1144 3486-0183 12.5 µM -1.47111656491539 0.0650977398696038 no 3147 0.0706297979873385 1017 6744069 SGTC_742 0kpi-0133 140 µM -1.47661938600598 0.0643789502357378 no 3148 0.0698888460905203 1019 2728852 SGTC_853 0419-0306 21 µM -1.47754085867529 0.0642591907442832 no 3149 0.0697653571276686 1019 762713 SGTC_2086 5274770 176.623 µM -1.48794409412995 0.0629191139547803 no 3150 0.0683828189002413 1009 689278 SGTC_1298 1079-1278 263 µM -1.48971803824841 0.0626927946046255 no 3151 0.0681491948228742 1023 2840950 SGTC_1049 3226-0134 66 µM -1.4915288533901 0.0624624261473867 no 3152 0.067911350849997 1023 5702385 SGTC_2178 5812956 200 µM -1.49222309950909 0.0623742807040547 no 3153 0.0678203343268757 1017 5403383 SGTC_1417 3966-0327 90.4 µM -1.49479161470156 0.0620490104542156 no 3154 0.0674844177127207 1027 651118 SGTC_2825 7998094 58.44 µM -1.49734551572899 0.0617269046369597 no 3155 0.0671516886573515 1021 2987815 SGTC_3103 9120822 49.47 µM -1.50102908753239 0.0612646223717417 no 3156 0.0666740191679243 1006 17141819 SGTC_563 tetrahydrosecaminediol 614 µM -1.50154133097881 0.0612005514589948 no 3157 0.0666078024588483 1032 334274 A psychoactive constituent of the cannabis plant. SGTC_900 1112-0045 141 µM -1.50713932016423 0.0605037686330562 no 3158 0.0658874749754778 1001 56211 YIL048W NEO1 SGTC_3252 9135871 49.47 µM -1.50916942108192 0.0602526206915961 no 3159 0.0656277462645429 1032 17682838 SGTC_381 3461-2219 42.7 µM -1.51050547356413 0.0600877806441742 no 3160 0.0654572468880617 1040 2883159 SGTC_2434 5670830 169.91 µM -1.51583997644938 0.0594331352840885 no 3161 0.0647799104338398 1035 1549830 SGTC_2707 st078556 66.6 µM -1.52047628692472 0.0588687244308544 no 3162 0.0641956570578327 1005 17250899 SGTC_2729 fluphenazine 10.66 µM -1.5206528273012 0.0588473163370449 no 3163 0.0641734912083141 1016 3372 An atypical antipsychotic. SGTC_512 prima-1 270 µM -1.52201473985082 0.0586823698828389 no 3164 0.0640026937149875 1030 322968 A re-activator of the apoptotic function of mutant p53. SGTC_294 k038-0071 157 µM -1.52533640104027 0.0582815926973746 no 3165 0.0635876064615331 1037 24152826 SGTC_2325 6158266 200 µM -1.52590626574849 0.0582130518859531 no 3166 0.0635166050159645 1012 3623240 SGTC_404 fumagillin 50 µM -1.52836628711337 0.0579178978417772 no 3167 0.0632108101473644 1010 12015870 A methionine aminopeptidase binder. SGTC_1300 1094-0077 113 µM -1.52852548515343 0.0578988378157138 no 3168 0.063191060472731 1029 5532636 SGTC_228 caffeine 993.056 µM -1.52957246085886 0.0577736111925282 no 3169 0.0630612952091397 1019 2519 Caffeine is a phosphodiesterase inhibitor. SGTC_527 4476-4215 268 µM -1.53167382493765 0.0575229140334747 no 3170 0.0628014723506698 1011 4418754 SGTC_2702 st077768 96.8 µM -1.53191592495322 0.0574940860476448 no 3171 0.0627715915956348 1009 6484119 SGTC_2532 xanthone 78.9 µM -1.53386501052837 0.0572624131363614 no 3172 0.0625314327183157 1046 7020 An insecticide. SGTC_2780 5215298 71.43 µM -1.53449219332826 0.0571880211431659 no 3173 0.0624543061711363 1026 2834131 SGTC_287 k060-0039 29.6 µM -1.55314561215273 0.0550100631879049 no 3174 0.0601941756499162 1024 5861974 SGTC_2424 5537928 59.2 µM -1.55459042214969 0.0548441411978567 no 3175 0.0600218231523049 1012 5382802 SGTC_1217 1183-1422 255 µM -1.55519772672867 0.0547745165217343 no 3176 0.0599494927791433 1020 2849664 SGTC_2745 rifampicin 24.3 µM -1.55668239690327 0.0546046001065373 no 3177 0.0597729550208969 1032 25141428 Inhibits bacterial DNA-dependent RNA polymerase. SGTC_1567 st069303 68.4 µM -1.56171917505817 0.054031258526247 no 3178 0.0591770797693247 1024 5581319 SGTC_117 lucigenin 22.078 µM -1.56399797619827 0.0537734308632828 no 3179 0.0589090218475667 1044 65100 An acridine derivative; a dye stuff and potential carcinogen. SGTC_2266 7929956 200 µM -1.56797393305137 0.0533259179102574 no 3180 0.0584436079396385 1029 2967153 SGTC_2866 9034245 58.44 µM -1.56903782968989 0.0532066732233636 no 3181 0.0583195622817448 1021 6462273 SGTC_609 0986-0026 86.3 µM -1.57139286864557 0.0529434653574251 no 3182 0.0580457107150793 1009 2848610 SGTC_2777 climbazole 1.536 µM -1.57422548272576 0.0526282511802336 no 3183 0.0577176650322956 1043 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2 SGTC_3356 9151811 4.48 µM -1.57452868585792 0.0525945990688429 no 3184 0.0576826375537512 1040 1859254 YPR165W RHO1 SGTC_826 1683-5028 118 µM -1.57514848510418 0.0525258615135055 no 3185 0.0576110873871411 1026 722377 SGTC_2602 kawain 100 µM -1.57698056005357 0.0523230958636983 no 3186 0.0573999991059372 1012 5369129 SGTC_813 k007-0158 173 µM -1.57712416515488 0.0523072286140097 no 3187 0.0573834789439875 1032 6523916 SGTC_3308 9128332 17.569 µM -1.57923032959329 0.0520749524660945 no 3188 0.0571416177940725 1015 17332805 YDL196W YDL196W SGTC_2237 6667747 47.222 µM -1.5803123752636 0.0519559392034096 no 3189 0.0570176735965352 1049 729940 YDL015C TSC13 SGTC_1270 0831-1170 17.3 µM -1.58645913923046 0.051283957597212 no 3190 0.0563175970723442 1023 6764716 SGTC_599 1935-0052 86.5 µM -1.58887149323899 0.0510221289938777 no 3191 0.0560447041276985 1037 9557311 SGTC_3068 9116768 49.47 µM -1.58996388008832 0.0509039155937137 no 3192 0.0559214735023543 1033 41904888 SGTC_1845 st056753 3.01 µM -1.59960377291081 0.0498701557877909 no 3193 0.0548432554721009 1017 5375839 SGTC_616 4092-0450 108 µM -1.60488962833216 0.0493104615626151 no 3194 0.0542590482279441 1043 787165 SGTC_3017 9080681 49.47 µM -1.61151793964608 0.0486157214297022 no 3195 0.0535334401639843 1032 16451914 SGTC_470 aa-861 153 µM -1.61910129051984 0.0478305015136518 no 3196 0.052712735600466 1015 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor. SGTC_42 0133-0086 60.653 µM -1.62015326850701 0.0477223807176017 no 3197 0.0525996785290828 1033 162923 Model of phenazepam hydroxylation. SGTC_1361 1608-0041 5.61 µM -1.62049934284319 0.0476868545058942 no 3198 0.0525625276883039 1037 X1361 SGTC_62 0180-0423 3.232 µM -1.62077370264524 0.0476587051933525 no 3199 0.0525330901552803 1034 30102 YGL099W LSG1 SGTC_1961 st076550 68.7 µM -1.62437964926013 0.0472899706084284 no 3200 0.052147403827856 1033 1579337 SGTC_2608 thymoquinone 42.66 µM -1.62727931757119 0.0469951197000453 no 3201 0.0518388942399803 1034 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC). SGTC_2452 5863136 48.41 µM -1.63250854640132 0.0464671167009439 no 3202 0.0512861997804482 1033 2184096 SGTC_1194 1488-0194 225 µM -1.63272027181261 0.0464458391835053 no 3203 0.0512639209533296 1038 1391452 SGTC_1483 3453-0561 55.9 µM -1.63318801701684 0.0463988604725777 no 3204 0.0512147297125179 1031 4546991 SGTC_1098 clofazimine 15.1 µM -1.63919354541181 0.0457990686539547 no 3205 0.0505864788344993 1033 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2 SGTC_1771 st048882 4.1505 µM -1.63919731524434 0.0457986941148357 no 3206 0.0505860864012356 1029 4580403 SGTC_2974 9094440 9.66 µM -1.64121282597348 0.0455988019867292 no 3207 0.0503766221006459 1025 25236134 SGTC_2555 cholic acid 100 µM -1.64142390023635 0.0455779089308492 no 3208 0.0503547260011952 1036 6708657 Influences liver metabolism. SGTC_2709 st078560 56 µM -1.64303727283675 0.0454184643866439 no 3209 0.0501876108586764 1049 17250903 SGTC_91 0417-1751 58.384 µM -1.64557246031424 0.045168826368565 no 3210 0.0499259064790105 1049 6795624 SGTC_1157 4092-0394 27.6 µM -1.64835411959534 0.0448961899698539 no 3211 0.0496400125478366 1044 3659885 SGTC_1240 0356-0016 42.1 µM -1.64840384905403 0.0448913279594591 no 3212 0.0496349133547098 983 4305613 SGTC_2773 thioridazine 9.09 µM -1.65902679235637 0.0438624085543332 no 3213 0.0485551967894541 1038 5452 An antipsychotic. SGTC_2033 5192550 145 µM -1.66479587951545 0.0433116462244966 no 3214 0.0479767431476435 1022 182073 SGTC_369 0957-0393 4.5 µM -1.66944540401043 0.0428718416054264 no 3215 0.0475145708840033 1037 6997992 SGTC_786 4544-0069 423 µM -1.68356617798053 0.0415582253513464 no 3216 0.0461327698841925 1035 748821 YLR208W SEC13 SGTC_1029 k015-0030 64.7 µM -1.69347193035588 0.0406563295384337 no 3217 0.0451828366976269 1021 2208316 SGTC_3237 9133362 49.47 µM -1.69611348205035 0.0404185241704418 no 3218 0.0449321954462923 1051 43845137 SGTC_492 tmb-8 126 µM -1.69869999449685 0.040186769300117 no 3219 0.0446878622444281 1047 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1 SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM -1.70393000457673 0.0397214517756229 no 3220 0.0441970823502999 1036 676296 Flavone; oxidizing agent. SGTC_185 k048-0037 25.491 µM -1.70951110381825 0.0392297391028355 no 3221 0.0436781583398834 1046 6827589 SGTC_1202 1988-0068 29.6 µM -1.71627274403609 0.0386406655918472 no 3222 0.0430560672337568 1043 2850480 SGTC_860 0443-0016 25.1 µM -1.71674504564477 0.0385997894673265 no 3223 0.0430128828961199 1046 5337942 SGTC_1285 0929-0069 65.5 µM -1.71686278482327 0.0385896050237983 no 3224 0.0430021230048188 1049 1206237 SGTC_1837 st055472 66.5 µM -1.71911310964385 0.0383953723565282 no 3225 0.04279688907808 1036 676091 SGTC_2941 9056145 11.23 µM -1.71950876168226 0.0383613048928901 no 3226 0.0427608868233852 1034 2119517 SGTC_1230 0170-0365 3.77 µM -1.72702828834085 0.0377185105930008 no 3227 0.0420812915918485 1008 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1 SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM -1.73095569226625 0.0373862942251702 no 3228 0.0417298336671649 1019 6708739 YPR165W RHO1 SGTC_497 capsazepine 133 µM -1.7371836995937 0.0368643747917959 no 3229 0.0411773755829997 1046 2733484 A calcium channel blocker. SGTC_1902 st060212 70.5 µM -1.74096886461013 0.0365500915439847 no 3230 0.0408445181463256 1030 688944 SGTC_1224 0823-0416 294 µM -1.75997966035502 0.035004610976762 no 3231 0.0392056276394384 1048 3598164 SGTC_3186 9110464 49.47 µM -1.7624208957584 0.0348100947255422 no 3232 0.038999105363161 1052 17018021 SGTC_1267 0828-0272 9.49 µM -1.76501860714824 0.0346040860648554 no 3233 0.0387803192760834 1049 745334 SGTC_734 2023-0417 80 µM -1.78540241709666 0.0330220958074823 no 3234 0.0370980334392502 1053 3935732 SGTC_1444 4112-3581 28 µM -1.7861303601402 0.0329667209241662 no 3235 0.0370390767245205 1053 2877249 SGTC_1780 st038448 24.544 µM -1.7879937728727 0.0328253190677992 no 3236 0.0368885062479671 1046 728868 YDL195W SEC31 SGTC_1190 1486-1332 13 µM -1.7893911070169 0.0327196131336738 no 3237 0.0367759252616537 1042 4150046 SGTC_1741 st038134 10.228 µM -1.78997429816516 0.0326755788163372 no 3238 0.0367290216625364 1058 1272587 SGTC_457 grayanotoxin iii 135 µM -1.79201729416675 0.0325217060486594 no 3239 0.0365650978901132 1029 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity. SGTC_2125 5246583 200 µM -1.79550714395141 0.0322602430843827 no 3240 0.0362864677846011 1063 835267 SGTC_1979 st071809 45.3 µM -1.79665076702238 0.0321749400704205 no 3241 0.0361955397454473 1055 4976333 SGTC_2174 5790901 200 µM -1.81144505357326 0.0310881205388407 no 3242 0.0350359936187259 1052 786020 SGTC_484 loperamide 105 µM -1.81969085418754 0.0304956660076789 no 3243 0.0344030484431273 1065 3955 An opioid-receptor agonist. SGTC_1565 sinapyl alcohol 95.1 µM -1.82136530899761 0.0303765074024605 no 3244 0.0342756724365501 1026 5280507 A phenol propionate derived from cinnamic acid. SGTC_2461 5755302 26.15 µM -1.82246948693896 0.0302981424744298 no 3245 0.0341918897422087 1064 2788904 SGTC_2920 7982904 15.77 µM -1.82286244322687 0.0302702943142986 no 3246 0.034162113696035 1055 6456808 SGTC_3149 9097855 49.47 µM -1.82899222463763 0.0298386264583509 no 3247 0.0337003865258783 1045 25236625 YMR079W SEC14 SGTC_2900 5328528 85.29 µM -1.83608880509665 0.0293452659700813 no 3248 0.0331722618589604 1054 795359 SGTC_2994 9053520 71.4286 µM -1.85233734588185 0.028241126189925 no 3249 0.0319886980629 1046 4647384 SGTC_2065 5221596 34.26 µM -1.8563419363899 0.0279743781845053 no 3250 0.0317024176048165 1046 788581 SGTC_1541 2',3',6-trimethoxyflavone 64 µM -1.85895060595701 0.0278017445055448 no 3251 0.0315170700099613 1071 688801 SGTC_702 1488-0190 94 µM -1.86331823058046 0.0275146961478215 no 3252 0.0312087533598667 1058 949357 SGTC_2794 7785382 27.27 µM -1.86389352746998 0.0274770713909705 no 3253 0.03116832893 1028 2205081 SGTC_1913 st060213 96.1 µM -1.86466797655655 0.0274264897138121 no 3254 0.031113979067263 1054 688959 SGTC_1778 st046819 58.9 µM -1.87673901008613 0.0266480781469801 no 3255 0.0302769366053226 1065 671715 SGTC_2906 7926292 26.41 µM -1.89003814259264 0.0258119248559044 no 3256 0.0293764294955754 1052 2966319 SGTC_1495 4469-0029 237 µM -1.89073422883113 0.0257687715563267 no 3257 0.029329915413284 1053 793680 SGTC_1573 oleylamine 1.06 µM -1.8990429347931 0.0252583255882366 no 3258 0.0287794155516194 1048 5356789 An amine of the fatty acid oleic acid. SGTC_2084 5306078 60.6385 µM -1.91282441364576 0.0244303493855788 no 3259 0.0278852673166962 1070 679340 SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM -1.9129080709911 0.024425393768335 no 3260 0.027879911077582 1063 4213774 SGTC_2661 dactinomycin 12.96 µM -1.9178541768631 0.0241338970998561 no 3261 0.0275647519697445 1058 45006140 An Actinomycin D Classic transcription inhibitor. SGTC_822 1487-0950 154 µM -1.92185781307746 0.023900089692323 no 3262 0.0273118257004209 1048 1958375 SGTC_2708 st078559 56 µM -1.93107272184929 0.0233691760959767 no 3263 0.0267370299182888 1039 17250902 SGTC_2064 5220758 200 µM -1.9347589322514 0.0231595932858677 no 3264 0.0265099424112583 1056 788518 SGTC_792 4534-1957 155 µM -1.94057161512202 0.022832324196234 no 3265 0.0261551299047646 1060 1717904 SGTC_3155 9099265 49.47 µM -1.94494303436771 0.0225887767651576 no 3266 0.0258909174136793 1054 25236499 SGTC_2150 5556613 200 µM -1.94685986660693 0.0224826759495834 no 3267 0.0257757686496123 1065 743190 SGTC_2423 st077119 87.2 µM -1.95010078200499 0.022304240273171 no 3268 0.0255820540378174 1049 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae). SGTC_2774 tamoxifen 10.92 µM -1.95097429216924 0.0222563521672076 no 3269 0.025530051996188 1053 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  SGTC_1062 mesoridazine 14.2 µM -1.96282272034384 0.0216153131156064 no 3270 0.0248333884134882 1062 4078 A neuroleptic. SGTC_903 1134-0042 114 µM -1.96363904791215 0.0215717275275019 no 3271 0.0247859828545016 1062 701009 SGTC_1719 st032227 49.2 µM -1.9667629063288 0.0214056229247034 no 3272 0.0246052754128653 1038 3125804 SGTC_2775 cyproheptadine 69.59 µM -1.97307039392012 0.0210735298448895 no 3273 0.0242437713968453 1062 2913 A selective serotonin reuptake inhibitor. SGTC_61 0978-8327 98.565 µM -1.99179359860549 0.0201133104825656 no 3274 0.0231968544536445 1047 6150059 YHR072W ERG7 SGTC_2199 6590217 200 µM -2.00336564844861 0.0195385940663375 no 3275 0.0225690278943836 1041 703109 SGTC_661 1304-0007 33.6 µM -2.00500942610422 0.0194580995278296 no 3276 0.022481019668625 1076 3117130 SGTC_1223 0764-0573 147 µM -2.00548999718229 0.0194346196136697 no 3277 0.022455344522798 1056 1609797 SGTC_834 0312-0008 75.7 µM -2.03521068997046 0.0180285580129986 no 3278 0.0209148389458714 1073 6385573 YIL048W NEO1 SGTC_1895 st058434 18.3 µM -2.04399761113762 0.0176298431547387 no 3279 0.0204768915724685 1077 5393175 SGTC_3111 9122088 49.47 µM -2.0452509352185 0.0175735902583307 no 3280 0.0204150626020801 1072 16876704 SGTC_68 0986-0284 82.829 µM -2.04655551955072 0.0175151994590925 no 3281 0.0203508729872752 1042 423278 YIL048W NEO1 SGTC_1257 0669-0121 16 µM -2.04723126645317 0.0174850194394002 no 3282 0.0203176914422842 1052 4307855 SGTC_1184 1269-1718 139 µM -2.04899130694767 0.0174066213448342 no 3283 0.0202314824876964 1067 5403821 SGTC_122 0236-0016 402.397 µM -2.04993982082243 0.0173644959771134 no 3284 0.0201851518503796 1045 6808838 SGTC_178 4092-0806 87.505 µM -2.05143427569717 0.0172983009641982 no 3285 0.0201123370040744 1037 2169044 SGTC_1297 1068-0111 14.1 µM -2.05611962409838 0.0170921648003067 no 3286 0.0198854935641782 1064 767057 SGTC_2993 9054257 71.4286 µM -2.05725545201641 0.017042510366909 no 3287 0.0198308300246908 1048 6470217 YGL055W OLE1 SGTC_2857 9024691 58.44 µM -2.0615547457343 0.0168556753812026 no 3288 0.0196250731361991 1063 16478292 SGTC_2148 5546263 113.568 µM -2.08379738140914 0.0159168074405564 no 3289 0.0185893008197649 1075 792097 SGTC_495 decylubiquinone 155 µM -2.09860470670493 0.0153169531290953 no 3290 0.0179258805579363 1075 2971 A Co-enzyme Q analog. A free radical scavenger. SGTC_2960 9079389 5.97 µM -2.10238169506921 0.0151670893581413 no 3291 0.017759926682077 1060 16457355 SGTC_1242 0402-0103 60.1 µM -2.10865524795063 0.0149209503804039 no 3292 0.0174871751611847 1064 432868 SGTC_2582 agaric acid 100 µM -2.11955909092728 0.0145013127325481 no 3293 0.0170216227578114 1054 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase. SGTC_233 rapamycin 362 pM -2.13642928416471 0.0138720834691064 no 3294 0.0163222196238211 1084 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C SGTC_1123 mangostin 811.285 nM -2.1577446802178 0.0131108355928597 no 3295 0.0154738440253758 1048 5281650 An antioxidant. SGTC_3342 9147791 14.508 µM -2.17967772672186 0.0123654874594542 no 3296 0.0146406793581467 1070 1838168 SGTC_1017 4239-0030 168 µM -2.18556462155127 0.0121717922445201 no 3297 0.0144237366608804 1069 1149593 SGTC_444 curcumin 90.4 µM -2.20200063138212 0.0116448602054959 no 3298 0.0138326319348519 1049 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. SGTC_2050 5263056 171 µM -2.20295195691695 0.0116149768247392 no 3299 0.0137990675003045 1073 763468 YGL055W OLE1 SGTC_981 1488-1094 54.9 µM -2.20791972253815 0.0114600068729639 no 3300 0.013624934868042 1072 3449522 SGTC_711 k292-0785 179 µM -2.21277549643568 0.0113102695017742 no 3301 0.0134565637166688 1059 4146315 SGTC_1885 st057546 99.9 µM -2.22628902620827 0.0109024700333559 no 3302 0.0129974140261507 1068 702008 SGTC_1097 itavastatin 7.23 µM -2.2318557869621 0.0107382388560277 no 3303 0.0128122479176826 1076 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49 SGTC_371 0195-0006 7.36 µM -2.24520003082455 0.0103532995211448 no 3304 0.0123776470665808 1044 3928593 SGTC_257 daunorubicin 18.5 µM -2.25018275914982 0.0102126792932304 no 3305 0.0122186731357781 1066 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_1534 6-azauridine 81.6 µM -2.25170000051894 0.010170192601583 no 3306 0.0121706183185279 1072 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1 SGTC_520 3584-0023 682 µM -2.26623924421146 0.00977081253735846 no 3307 0.0117183695229338 1065 1340790 SGTC_2784 7567673 72.73 µM -2.28012448814093 0.00940225652640762 no 3308 0.0113001531182801 1066 3471247 SGTC_1326 1431-2094 10.8 µM -2.2821086209933 0.00935059720272126 no 3309 0.0112414640760077 1071 616278 SGTC_1048 3161-0300 24.5 µM -2.28639936182642 0.0092397308962111 no 3310 0.0111154528196622 1076 2165101 SGTC_1013 4112-3890 241 µM -2.2895397084865 0.00915931979089091 no 3311 0.0110240067510795 1074 705171 SGTC_3118 9124250 49.47 µM -2.32527851951248 0.00828647624469224 no 3312 0.0100285360632528 1069 1504786 SGTC_559 1550-0661 158 µM -2.36537749527508 0.00739487861628432 no 3313 0.00900585056723165 1085 5830875 SGTC_1165 k072-0275 30.3 µM -2.37327279745046 0.00722964541873972 no 3314 0.00881561829220733 1079 6153523 YGL055W OLE1 SGTC_1614 st002383 48.6 µM -2.39731774544522 0.00674631575453429 no 3315 0.00825779743930209 1085 1947235 SGTC_2781 5567276 71.43 µM -2.40047239706076 0.00668507094377031 no 3316 0.00818696280948397 1070 2853274 SGTC_2012 4023501 200 µM -2.41165412478411 0.00647192695393663 no 3317 0.00794016917978812 1080 3477460 SGTC_2556 citropten 84.59 µM -2.41196881134567 0.00646601643765706 no 3318 0.00793331936708891 1071 2775 A potential DNA crosslinker. SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM -2.4398629943726 0.00596070397943036 no 3319 0.00734641652004404 1090 2724278 An inhibitor of dopamine biosynthesis. SGTC_2595 hexamethylquercetagetin 100 µM -2.45017787400569 0.00578290812246965 no 3320 0.00713928295434597 1080 386331 SGTC_263 alizarin 107.927 µM -2.45479644994804 0.00570483534586705 no 3321 0.00704821909759179 1070 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. SGTC_1550 gossypolone 36.6 µM -2.46190042607089 0.00558657497781589 no 3322 0.00691015149013975 1086 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_1789 tunicamycin 25 nM -2.52208474276947 0.00466890135748093 no 3323 0.00583307999657444 1061 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_173 1273-0061 2.693 µM -2.5239993216886 0.0046420557828134 no 3324 0.00580140762537044 1050 2847414 YPL266W DIM1 SGTC_660 4031-1742 102 µM -2.53389451304749 0.00450549232770367 no 3325 0.00564013416742678 1078 6738706 SGTC_1968 st069590 43.6 µM -2.53486021599175 0.004492358739397 no 3326 0.00562461022289516 1077 6384066 SGTC_2834 9001755 58.44 µM -2.54064436724352 0.00441440734526627 no 3327 0.00553242013509401 1069 2989575 SGTC_3030 9087619 49.47 µM -2.65386115287446 0.00311319958665316 no 3328 0.00397882817365387 1083 25236973 SGTC_1919 st067113 52.3 µM -2.68020098575401 0.00286509090085886 no 3329 0.00367889837674323 1075 1268243 SGTC_2543 pimpinellin 60.67 µM -2.6856037853273 0.00281645893584251 no 3330 0.00361994429073799 1084 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo. SGTC_264 promethazine 12.5 mM -2.71278174204399 0.00258293558773908 no 3331 0.00333605179675862 1087 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3 SGTC_2802 7925815 54.55 µM -2.73617974751323 0.00239606499405698 no 3332 0.00310785318218641 1080 1262923 SGTC_2870 9038528 12.99 µM -2.75741728511692 0.00223713465784295 no 3333 0.00291299754711922 1093 6463316 SGTC_1786 berberine 21.6 µM -2.75989751180003 0.00221921086924493 no 3334 0.00289097486165596 1041 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_2269 7935389 174.42 µM -2.78233762866348 0.00206286283500731 no 3335 0.00269844315103369 1083 97605 SGTC_1727 st034309 9.9045 µM -2.79144275928631 0.00200232670474361 no 3336 0.00262368190102425 1088 870305 SGTC_3238 9133470 49.47 µM -2.81390916719519 0.00185979582583487 no 3337 0.00244715278288008 1088 3534688 SGTC_2835 9006588 71.43 µM -2.83506560560688 0.00173407260354398 no 3338 0.00229081379479329 1059 2345538 SGTC_1788 fluconazole 20 µM -2.83536980425823 0.00173232269556768 no 3339 0.0022886333852498 1086 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11 SGTC_116 0155-0182 31.788 µM -2.83812394542621 0.00171655244600529 no 3340 0.0022689778652413 985 771486 SGTC_3058 9093861 49.47 µM -2.8409341363111 0.00170059605894089 no 3341 0.00224908007078075 1084 17217477 SGTC_517 1365-0151 113 µM -2.85224874640684 0.00163770843244952 no 3342 0.00217055577817976 1083 768657 SGTC_421 streptovitacin 30 mM -2.89583009078501 0.00141478046201003 no 3343 0.00189078543442983 1083 91467 include heat shock SGTC_542 3381-0244 89.3 µM -2.91400222143794 0.00133030101385611 no 3344 0.00178413683711844 1093 1112843 SGTC_3114 9122766 49.47 µM -2.93967032811227 0.00121881651626198 no 3345 0.0016428081362484 1086 17176985 SGTC_1022 4477-0945 21.3 µM -2.97676499820906 0.00107276073440686 no 3346 0.00145653603830518 1083 4648966 SGTC_1338 1486-1223 76 µM -2.99721263376226 0.000999289035051586 yes 3347 0.00136230299370907 1090 3444526 SGTC_3001 9076041 71.4286 µM -3.07558119147293 0.000758447219729999 yes 3348 0.00105046359655499 1092 16004211 SGTC_1491 4138-0063 26.5 µM -3.18386657907239 0.000512929499422788 yes 3349 0.0007266098876303 1094 23883227 SGTC_1690 st023502 41.2 µM -3.2182835940762 0.000451856354113413 yes 3350 0.000644801214289109 1090 24207482 SGTC_275 trichlorophene 5.69 µM -3.33461928824866 0.00029179413629025 yes 3351 0.00042708127714519 1094 62616 SGTC_2008 4012253 172 µM -3.38132791936911 0.000243871161825987 yes 3352 0.000360681998068432 1087 603940 SGTC_778 3456-2434 196 µM -5.89094524346688 5.97508327208602e-10 yes 3353 1.91996393155188e-09 1075 5539063