SGTCid condition conc unit SNF4|YGL115W.score SNF4|YGL115W.strain.pval SNF4|YGL115W.strain.significant SNF4|YGL115W.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene SGTC_2448 5185112 27.17 µM 9.59473635607198 8.48330076457745e-18 yes 1 4.20659565346218e-22 1 5718189 SGTC_2057 5236571 38.335 µM 8.80186359087885 2.78774356277952e-15 yes 2 6.72813418433926e-19 3 54684039 YBR257W POP4 SGTC_571 k831-0106 44.2 µM 8.02156511663689 5.21868520555599e-13 yes 3 5.22031046250954e-16 2 4783639 SGTC_114 0364-0001 490.298 µM 7.9519113302394 8.13873779426304e-13 yes 4 9.18278450491721e-16 4 4003655 SGTC_2446 5162541 200 µM 7.89278420760334 1.18337216835647e-12 yes 5 1.47759173394752e-15 1 1549321 SGTC_2438 5259590 200 µM 7.70413106922743 3.83747595693666e-12 yes 6 6.58682922778363e-15 1 1201127 SGTC_1320 1313-0481 95.3 µM 6.65809935406709 1.59602956906998e-09 yes 7 1.38695623370396e-11 1 6813365 YLR208W SEC13 SGTC_1032 k061-1018 98.7 µM 6.18016670904715 1.90278340289076e-08 yes 8 3.20169732089181e-10 1 4005393 SGTC_2094 5332512 191.667 µM 6.15774647432908 2.12831334894388e-08 yes 9 3.68936761294073e-10 6 755774 SGTC_108 0509-0257 621.132 µM 6.05434030440351 3.55028008014696e-08 yes 10 7.04971335750176e-10 13 536624 SGTC_2953 9074162 66.49 µM 5.92729867432258 6.58379566129441e-08 yes 11 1.53979276156342e-09 5 16451992 SGTC_110 0850-0284 111.64 µM 5.61483752785863 2.85520342608772e-07 yes 12 9.83735115332883e-09 8 3906265 SGTC_103 0844-0104 51.839 µM 5.56595464305099 3.56800732231374e-07 yes 13 1.30360529712549e-08 85 5375804 SGTC_2179 6298986 200 µM 5.4300260073758 6.56840717271249e-07 yes 14 2.81729200488003e-08 6 738374 SGTC_120 rhodamine 6G 52.259 µM 5.08181805524097 2.94371935213882e-06 yes 15 1.86919704532204e-07 13 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase SGTC_1894 3',6'-dihydroxyflavone 78.7 µM 5.00887411202349 3.98438124592025e-06 yes 16 2.73746839804606e-07 6 688662 SGTC_577 r071-0003 38.6 µM 4.86811275782528 7.06585874633517e-06 yes 17 5.63345205922969e-07 29 4568517 YMR134W ERG29 SGTC_928 2764-0428 58.7 µM 4.81287317972794 8.81145993897101e-06 yes 18 7.43878533591706e-07 33 662578 SGTC_2584 androsterone 48.74 µM 4.72999145981637 1.22195841675844e-05 yes 19 1.12264641049843e-06 89 2754130 A steroid. SGTC_568 1193-0097 7.48 µM 4.59446930913606 2.06285936437147e-05 yes 20 2.16925986382153e-06 108 3646150 SGTC_616 4092-0450 108 µM 4.58293298866663 2.15552962406714e-05 yes 21 2.29249503389827e-06 5 787165 SGTC_2106 5357045 167.29 µM 4.56657202366029 2.29374964135559e-05 yes 22 2.47882373966268e-06 8 668842 SGTC_531 3788-1495 174 µM 4.52369388980755 2.69696663517334e-05 yes 23 3.03847987930242e-06 12 2896655 SGTC_1053 3366-3204 134 µM 4.46384801406181 3.37321717582137e-05 yes 24 4.02503383711983e-06 23 3632071 YPR165W RHO1 SGTC_1123 mangostin 811.285 nM 4.43063714571304 3.81477532560397e-05 yes 25 4.6977535046073e-06 26 5281650 An antioxidant. SGTC_3311 9131146 2.8755 µM 4.42718541174466 3.86368052925241e-05 yes 26 4.77353320204248e-06 99 4900406 YPR165W RHO1 SGTC_1871 st057448 67.3 µM 4.37727425198988 4.64052517026498e-05 yes 27 6.00863623671079e-06 16 691747 SGTC_1343 1487-0095 224 µM 4.24789326461709 7.39756337956699e-05 yes 28 1.07895076427155e-05 7 4560101 YGL055W OLE1 SGTC_263 alizarin 107.927 µM 4.13098137771919 0.000111549817488332 yes 29 1.80608923082178e-05 52 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. SGTC_2498 4'-Methoxychalcone 54.63 µM 4.10361275354418 0.000122629240760208 yes 30 2.03374038255617e-05 31 641818 YHR062C RPP1 SGTC_1392 3455-1037 33.9 µM 4.06461144694607 0.000140211789570633 yes 31 2.4056272787535e-05 11 981132 SGTC_2789 5281112 71.43 µM 4.06422010202257 0.000140399628135825 yes 32 2.40966662672722e-05 35 765948 SGTC_1822 st052468 42 µM 3.97970508919689 0.00018697495098896 yes 33 3.45004058125098e-05 11 2873678 SGTC_773 4358-1457 44.6 µM 3.9621062541185 0.000198337187975294 yes 34 3.71457312635013e-05 43 1186886 SGTC_3113 9123498 49.47 µM 3.95476465572726 0.000203265166134496 yes 35 3.83050130311083e-05 11 8897275 SGTC_1312 1218-2183 165 µM 3.94395144794238 0.000210732076305321 yes 36 4.00749460096884e-05 8 6744073 SGTC_711 k292-0785 179 µM 3.91647210012568 0.000230875936477544 yes 37 4.49271045228042e-05 24 4146315 SGTC_2396 5342950 42.78 µM 3.89210692242811 0.000250225757957633 yes 38 4.96887138783101e-05 44 1886677 SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM 3.85472557077599 0.00028287201197842 yes 39 5.79297586652443e-05 32 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1 SGTC_863 0466-0191 129 µM 3.78559296570537 0.000353925731125092 yes 40 7.66712466700939e-05 73 765160 YPR165W RHO1 SGTC_3145 9085516 49.47 µM 3.76885048353012 0.000373467517964403 yes 41 8.20005421566698e-05 35 25236195 SGTC_3132 9126706 49.47 µM 3.76606060556615 0.00037681965048473 yes 42 8.2921775642848e-05 27 850858 SGTC_64 000l-0018 272.079 µM 3.76188884170765 0.000381884323138348 yes 43 8.43174983742101e-05 163 6811119 SGTC_1534 6-azauridine 81.6 µM 3.7546045604482 0.00039087951444883 yes 44 8.68076793856845e-05 29 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1 SGTC_1337 1486-1011 40.3 µM 3.70537027353622 0.00045702659295116 yes 45 0.000105541072267607 19 X1337 SGTC_2582 agaric acid 100 µM 3.69240909451952 0.000476088996829265 yes 46 0.000111069877414792 345 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase. SGTC_1648 st011736 69.8 µM 3.69148428192794 0.00047747691187077 yes 47 0.000111474588375409 19 2855514 SGTC_916 4466-0038 42 nM 3.68469278991998 0.000487784649737856 yes 48 0.000114489326876666 82 5722064 YGL116W CDC20 SGTC_1819 st053448 58.6 µM 3.66170073919725 0.000524229961700428 yes 49 0.000125273215060227 27 2857616 SGTC_3321 9137793 26.8275 µM 3.6577622501211 0.000530720137981731 yes 50 0.000127213441360832 86 4904192 SGTC_2442 5158906 48.48 µM 3.63960119909303 0.000561620310684701 yes 51 0.000136530304812804 28 1893835 SGTC_1728 st035614 33.7865 µM 3.63736401415602 0.000565539759232063 yes 52 0.000137721264937925 67 15945546 SGTC_175 3793-3120 23.7 µM 3.63345139772492 0.000572455329794231 yes 53 0.000139827572108198 21 5322297 SGTC_2056 5235370 200 µM 3.61842527911082 0.00059974697973437 yes 54 0.000148200524286101 55 5511916 SGTC_1497 4476-2978 41.3 µM 3.57969326271802 0.000675732936696155 yes 55 0.000171998879602885 18 1528379 SGTC_442 cape 100 µM 3.56555546990243 0.00070561400206819 yes 56 0.000181543176903563 23 5281787 SGTC_1193 1488-0126 41.5 µM 3.52611438440388 0.000795533720005015 yes 57 0.000210852395037809 39 1384710 SGTC_2191 5911152 200 µM 3.52423670709523 0.00080006681166319 yes 58 0.000212352331350695 26 2875902 SGTC_2970 9090938 41.86 µM 3.51701659186967 0.000817720017304301 yes 59 0.000218213250282368 62 17217104 SGTC_2218 6965428 192.983 µM 3.50247578697924 0.000854364980151833 yes 60 0.000230477838767452 12 675684 SGTC_1769 st044406 64.4 µM 3.49666534836189 0.000869425932330832 yes 61 0.000235556214889702 28 670903 SGTC_949 1165-0505 146 µM 3.47280348515696 0.000933872082380193 yes 62 0.000257526165100496 33 6244267 SGTC_1512 0259-0544 12.2 µM 3.46448882865174 0.000957340030263348 yes 63 0.000265620101939917 36 18476 SGTC_1309 pyrazolanthrone 13.4 µM 3.43139101362102 0.00105622622861429 no 64 0.000300247183377819 34 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14 SGTC_2430 5571206 200 µM 3.40710201544004 0.00113466099288681 no 65 0.000328282910486497 78 1731771 SGTC_2439 5492030 7.2 µM 3.40111066981567 0.00115481184396129 no 66 0.000335563258156229 26 5722370 SGTC_188 3229-0966 278.469 µM 3.39641885287404 0.00117082021667041 no 67 0.000341368988309956 47 5722370 SGTC_2567 aureobasidin a 60 nM 3.36869542274617 0.00126963227332912 no 68 0.000377624180851727 122 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1 SGTC_2572 astragaloside iv 100 µM 3.36038954997919 0.00130068772952063 no 69 0.000389163221976245 50 45006101 An anti-inflammatory agent. SGTC_2388 9080168 200 µM 3.33858114837026 0.00138556319729443 no 70 0.000421037153467628 16 15943073 SGTC_965 1291-5240 308 µM 3.33295925034354 0.00140824810915468 no 71 0.000429637633376896 53 2834598 SGTC_1150 3909-7983 10.9 µM 3.29572746449153 0.00156724530077338 no 72 0.000490835985233935 52 23965914 SGTC_1846 st056244 14.8 µM 3.28629916403849 0.00161002474088703 no 73 0.000507565670338389 62 5393182 SGTC_195 4234-0266 16.654 µM 3.2459440431704 0.00180541485050668 no 74 0.00058530923163221 70 2303354 SGTC_1426 4048-4480 71.7 µM 3.2421822351221 0.00182468565539826 no 75 0.000593090732566684 41 14224343 SGTC_2385 9074692 200 µM 3.24185752636598 0.00182635779575939 no 76 0.000593766871771776 72 17046906 SGTC_1459 k035-0031 35.7 µM 3.23949000772729 0.0018385918960151 no 77 0.000598718310326643 42 3877128 YMR208W ERG12 SGTC_1049 3226-0134 66 µM 3.23307410474321 0.00187212142293874 no 78 0.00061232895209927 62 5702385 SGTC_1421 4029-0249 71.4 µM 3.21027416354019 0.00199581931125059 no 79 0.000663042126547363 38 2894095 SGTC_89 0302-0250 142.109 µM 3.1872325967423 0.00212832330981985 no 80 0.000718206051186699 57 4203518 YLR208W SEC13 SGTC_682 0kpi-0099 17 µM 3.18496168050792 0.00214180523274481 no 81 0.000723865885402693 109 1714895 YML126C ERG13 SGTC_593 1203-0218 61.7 µM 3.10236077519015 0.00268802999993701 no 82 0.000959919146833835 36 3666956 SGTC_2240 6690706 185.951 µM 3.06992122044475 0.00293491764505088 no 83 0.00107057620291418 41 805876 SGTC_211 3455-0679 143.504 µM 3.06347641897838 0.00298633497351234 no 84 0.00109390723438742 53 748649 SGTC_161 4065-0411 162.148 µM 3.06291907526051 0.00299081943123523 no 85 0.00109594662999603 114 1906281 YLR208W SEC13 SGTC_2349 9023730 187.07 µM 2.9868578539486 0.00366283986977125 no 86 0.00140930371993525 81 4126287 SGTC_13 0199-0087 65 µM 2.97814899220138 0.00374784993323376 no 87 0.00144997488884145 41 4589825 SGTC_266 formosanin C 406 nM 2.96752830904041 0.00385391379635589 no 88 0.00150102318165813 122 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1 SGTC_197 4544-0043 41.561 µM 2.94926193822971 0.00404263753010187 no 89 0.00159266936871552 102 896523 SGTC_2756 carbadox 75.1 µM 2.93727453623527 0.00417094302362479 no 90 0.00165555419706278 125 2553 A substituted quinoxaline antibiotic. YLR208W SEC13 SGTC_373 0844-0104 25.9 µM 2.92816285677305 0.0042708926891734 no 91 0.00170485698404436 117 5375804 SGTC_326 k292-0812 17.5 µM 2.92558096112677 0.004299601247438 no 92 0.00171906850737268 32 3579357 SGTC_2818 7996756 12.99 µM 2.91214903911853 0.00445175442384427 no 93 0.00179475660689269 55 2241621 SGTC_1423 4048-0112 5.59 µM 2.90413991870446 0.00454475165814274 no 94 0.00184131770864017 76 X1423 SGTC_22 0964-0034 14.468 µM 2.88605438708731 0.00476115850945855 no 95 0.00195052369050694 102 138402 SGTC_514 4466-0038 2.65 nM 2.87253486571115 0.00492888338593574 no 96 0.00203596572286174 234 5722064 SGTC_2550 chrysin dimethyl ether 71.87 µM 2.86402298832282 0.00503716449948334 no 97 0.0020914882642336 31 88881 An O-methylated flavonoid and antioxidant. SGTC_1393 3470-5649 58.2 µM 2.85730203987244 0.00512415427485469 no 98 0.00213629527148426 47 4108395 SGTC_1503 4585-0012 61.3 µM 2.8424091208865 0.00532169519408529 no 99 0.00223869970519714 68 2922052 SGTC_607 4491-0986 66.8 µM 2.84019349070176 0.00535165509801958 no 100 0.00225430887435575 80 698981 YDR232W HEM1 SGTC_629 3448-6466 76.7 µM 2.83620536711893 0.00540596089844426 no 101 0.00228265397681872 77 573744 SGTC_200 k038-0079 37.545 µM 2.81483799552792 0.00570534412169927 no 102 0.00244009143237831 107 3436683 SGTC_3010 9080089 71.4286 µM 2.81379416230314 0.00572033946311157 no 103 0.00244802838415442 72 17027233 SGTC_2706 st078239 82.5 µM 2.80660004075651 0.00582464248413498 no 104 0.0025033681634007 74 15434492 SGTC_3223 9129970 49.47 µM 2.80590897831938 0.00583475004376221 no 105 0.00250874316888729 74 17248386 SGTC_2558 carylophyllene oxide 100 µM 2.79186838544668 0.00604350671112741 no 106 0.00262023335567619 73 6708694 An oxygenated terpenoid and antifungal agent. SGTC_2198 6589944 200 µM 2.78960038545435 0.00607784150579861 no 107 0.00263865667797215 50 5290268 SGTC_1739 st037196 92.5 µM 2.78741134303703 0.00611114480451914 no 108 0.00265654950337504 85 612214 SGTC_1710 st031758 61.5 µM 2.78728959020718 0.00611300184557775 no 109 0.00265754789782921 55 5394341 SGTC_1752 st044819 83.042 µM 2.78320412223988 0.00617560623429602 no 110 0.00269124654521354 86 441209 YML126C ERG13 SGTC_2608 thymoquinone 42.66 µM 2.77347335737783 0.00632700989772356 no 111 0.00277306907901172 78 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC). SGTC_1812 st052057 4.327 µM 2.76008917946007 0.00654062291494887 no 112 0.00288927925128323 95 3645418 SGTC_512 prima-1 270 µM 2.74649246476821 0.00676413455086214 no 113 0.00301181348575864 73 322968 A re-activator of the apoptotic function of mutant p53. SGTC_2051 5263410 176 µM 2.73388141100395 0.00697744829832978 no 114 0.00312962916467573 67 227584 SGTC_1902 st060212 70.5 µM 2.72396420811247 0.00714934508548955 no 115 0.00322517482289585 86 688944 SGTC_1873 rapamycin 2 nM 2.71752423567842 0.0072629610260009 no 116 0.00328861691209555 152 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1 SGTC_3322 9139058 2.11 µM 2.71705510325243 0.00727129947516022 no 117 0.00329328203900363 95 4908926 YPR165W RHO1 SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM 2.70140003517227 0.00755443972899362 no 118 0.00345241167299152 34 4620898 SGTC_775 4577-0580 57.3 µM 2.70049133881135 0.00757116876407119 no 119 0.00346185698829327 57 2006902 SGTC_2797 7859098 81.82 µM 2.69100855696528 0.00774770217557853 no 120 0.0035618183824603 105 972681 SGTC_850 0388-0143 75.9 µM 2.68526358906371 0.00785640492884797 no 121 0.0036236312687276 82 67273 SGTC_1810 st050138 53 µM 2.68463654650813 0.00786835026940455 no 122 0.00363043585982215 58 3444541 SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM 2.66908583247066 0.0081697511412373 no 123 0.00380290054834483 117 4174840 SGTC_578 3460-0051 92 µM 2.66016218623387 0.0083472493226715 no 124 0.00390515159840483 81 2876744 SGTC_805 3852-0218 479 µM 2.66004046539389 0.00834969367048863 no 125 0.00390656319607823 149 6615355 SGTC_1881 5652484 16 µM 2.64262120831889 0.00870604579059703 no 126 0.00411335069570342 113 2255129 SGTC_2757 clomiphene 4.22 µM 2.6401160946027 0.00875837556437906 no 127 0.00414388156443479 143 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined. SGTC_142 0335-0849 62.6745 µM 2.63760415879091 0.00881112452459438 no 128 0.00417469900017193 247 3889043 YPR107C YTH1 SGTC_2659 sanguinarine 24.21 µM 2.62334021086006 0.00911596979526101 no 129 0.00435361388677932 88 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis. SGTC_1544 7-methoxy-4-methylcoumarin 105 µM 2.62155838991312 0.00915469184874678 no 130 0.00437643835668667 94 390807 SGTC_25 0118-0223 35.662 µM 2.61907328745544 0.00920893785401571 no 131 0.00440845015708169 93 5333628 SGTC_1667 st014849 34.6 µM 2.61542638879832 0.0092890534401508 no 132 0.00445580640456028 60 5348460 SGTC_786 4544-0069 423 µM 2.61323737659038 0.00933743431103677 no 133 0.00448444922194889 126 748821 YLR208W SEC13 SGTC_1351 1496-0003 46.5 µM 2.61253247666902 0.00935306064614076 no 134 0.00449370764377282 92 3891978 SGTC_1607 st000305 50.6 µM 2.60912642763484 0.00942888925553435 no 135 0.00453868491695371 83 5457690 SGTC_177 1327-0068 8.361 µM 2.60397135340951 0.00954467895346126 no 136 0.00460752293073154 140 15389900 YOR207C | YLR033W RET1 | RSC58 SGTC_2727 riluzole 51.77 µM 2.59843741217694 0.00967036015797724 no 137 0.00468245577068407 70 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.  SGTC_107 0358-0022 2.6945 µM 2.59778895201176 0.00968518156234869 no 138 0.0046913070861646 69 521106 YGL093W | YPR107C SPC105 | YTH1 SGTC_2783 7738165 71.43 µM 2.56546702862203 0.0104495403456594 no 139 0.0051518506755485 102 17201110 SGTC_2100 5377183 190 µM 2.56328318812873 0.0105030304215761 no 140 0.00518437190293891 91 2844202 SGTC_1011 4112-3381 17.4 µM 2.54719896410195 0.0109043922011939 no 141 0.00542957498767767 128 2877139 SGTC_359 0081-0058 15.9 µM 2.5307739807146 0.0113279663332167 no 142 0.00569055801250088 158 3494159 SGTC_1755 st041960 45.185 µM 2.5195763362655 0.0116248680484462 no 143 0.0058748080037252 112 2257073 SGTC_1202 1988-0068 29.6 µM 2.50826944313053 0.0119314986447598 no 144 0.00606620570857455 133 2850480 SGTC_3233 9132340 49.47 µM 2.48719392830684 0.0125218013099805 no 145 0.00643775957113773 97 17682950 SGTC_523 1934-0222 13.7 µM 2.48517214615408 0.0125797364167048 no 146 0.00647444002266441 131 1361595 SGTC_1965 Pectolinarigenin 58.4 µM 2.48086747951644 0.0127038620455918 no 147 0.00655315447187957 88 5320438 An anti-inflammatory. SGTC_1394 3474-0001 65.7 µM 2.47157891257604 0.0129753144451103 no 148 0.0067258929593633 119 5017666 YIL048W NEO1 SGTC_1194 1488-0194 225 µM 2.46878003727192 0.0130580868574373 no 149 0.00677872631629154 146 1391452 SGTC_955 1216-0110 33 µM 2.45044074973479 0.0136118183219869 no 150 0.00713407214584195 199 3619719 SGTC_2479 5617353 43.85 µM 2.44364275075558 0.013822162874013 no 151 0.00726990810671951 146 2731746 SGTC_3104 9120930 49.47 µM 2.42367252161941 0.0144563739096325 no 152 0.00768222673484452 104 17014836 SGTC_3351 9150312 21.596 µM 2.42291992129938 0.0144807568424882 no 153 0.0076981600720957 133 4904905 SGTC_997 3996-0078 137 µM 2.4126707879656 0.0148163507963251 no 154 0.00791805809693847 149 735687 SGTC_3087 9117406 49.47 µM 2.40917023650431 0.014932493790369 no 155 0.00799441900275577 112 42546093 SGTC_427 1354-0053 47.3 µM 2.40021318182529 0.0152332448120159 no 156 0.00819276303888272 140 6813657 SGTC_1764 st044502 93.5 µM 2.39938613046802 0.0152612753064518 no 157 0.00821129337541083 143 8407 SGTC_1342 1486-1464 234 µM 2.39905674001091 0.0152724513649807 no 158 0.00821868371426845 120 3253938 SGTC_3193 9111931 49.47 µM 2.39818939123113 0.0153019137194827 no 159 0.00823817186234223 125 17087244 SGTC_1826 st055655 41.6 µM 2.39514258337477 0.0154057957837981 no 160 0.00830695159316855 154 676168 SGTC_974 1326-0144 138 µM 2.3849760393173 0.0157568203871843 no 161 0.00854011688732957 165 5411856 SGTC_2568 diosmetin 100 µM 2.3848918407929 0.0157597559543349 no 162 0.00854207167956655 142 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.  SGTC_638 3970-0837 4.09 µM 2.3723682155346 0.0162016461394319 no 163 0.00883723347364559 161 4118451 YLR208W SEC13 SGTC_1466 k213-0079 57.5 µM 2.36913642656999 0.0163173865871877 no 164 0.00891483765549706 130 3657981 SGTC_3266 9136860 49.47 µM 2.36623885694836 0.0164217589412905 no 165 0.00898492332170023 172 4871271 YPR165W RHO1 SGTC_2966 9084041 48.03 µM 2.3584034870907 0.0167068610769864 no 166 0.00917686582853499 153 17741380 SGTC_1671 st016596 74.5 µM 2.34392362003478 0.0172448858119562 no 167 0.00954103935668462 138 2829167 SGTC_1865 st057639 52.2 µM 2.33791419307018 0.0174724850297419 no 168 0.00969584992354937 121 688818 SGTC_1932 st074806 40.9 µM 2.33673177238074 0.0175175683590028 no 169 0.00972656769654059 154 17251235 SGTC_1124 fisetin 1.16336 µM 2.33187523695937 0.0177037813623511 no 170 0.00985362777069556 167 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster. SGTC_492 tmb-8 126 µM 2.32860178928007 0.0178302451191329 no 171 0.0099400855959158 54 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1 SGTC_1360 1598-0022 39.8 µM 2.32260724999299 0.0180638315193289 no 172 0.0101001304464034 209 761525 SGTC_924 2046-0044 21.3 µM 2.3224596571707 0.0180696154507079 no 173 0.0101040991438063 122 3623589 SGTC_2912 7964298 10.93 µM 2.32043494248808 0.0181491203658244 no 174 0.0101586802348946 245 2975850 SGTC_2848 9016370 25.97 µM 2.32006283548737 0.0181637643591195 no 175 0.0101687392120783 152 7894410 SGTC_807 1315-0151 48 µM 2.31961179967268 0.0181815280368628 no 176 0.0101809434792896 169 4011080 SGTC_2512 diallyl trisulfide 49.23 µM 2.31017441088518 0.0185566217773713 no 177 0.0104392500677831 88 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent SGTC_81 0411-0046 9.971 µM 2.29109223406356 0.0193352121132923 no 178 0.0109790398558499 135 12925265 SGTC_2293 7624732 200 µM 2.28990236665203 0.0193846671150671 no 179 0.0110134885102377 149 894453 SGTC_951 1171-0579 82.7 µM 2.28873899618102 0.019433124682501 no 180 0.0110472609056256 268 1616050 YPR165W | YDR526C RHO1 | YDR526C SGTC_2387 9077560 195.08 µM 2.28157396226644 0.019733842076466 no 181 0.0112572527102028 146 5303272 SGTC_3124 9127567 49.47 µM 2.2740901697078 0.0200521464329941 no 182 0.0114802828124076 128 17592030 SGTC_328 k915-0120 63.5 µM 2.25931380286546 0.0206934221173838 no 183 0.0119319359598222 147 6624543 SGTC_204 PMA1.184 62.41 µM 2.25564986463828 0.0208550930666852 no 184 0.0120462838545381 170 2252213 YGL008C PMA1 SGTC_1118 chelidonine 707.474 nM 2.24971576199399 0.0211192027521928 no 185 0.0122334971557092 167 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor. SGTC_704 1310-0270 142 µM 2.24812407024381 0.0211905237438076 no 186 0.0122841398116508 181 5718033 SGTC_2475 5812728 15.03 µM 2.24440031652826 0.0213581750057515 no 187 0.01240332808661 167 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2 SGTC_1647 st011722 22.4 µM 2.2432683596647 0.0214093598414835 no 188 0.01243975721064 124 2854783 SGTC_407 eburnamonine 100 µM 2.24232553535995 0.0214520716038731 no 189 0.0124701702819176 145 3195 SGTC_71 0417-1750 47.813 µM 2.24036846994144 0.0215409604242923 no 190 0.0125335057386679 194 6811472 SGTC_232 clozapine 119 µM 2.23065248787241 0.0219868769244122 no 191 0.0128520785590179 213 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_1442 4112-3290 3 µM 2.21925083195241 0.0225200719500298 no 192 0.0132348322966643 166 704353 SGTC_1165 k072-0275 30.3 µM 2.21868346966561 0.0225468868071114 no 193 0.0132541332012535 174 6153523 YGL055W OLE1 SGTC_918 glabranin 770.725 nM 2.21811638963043 0.0225737152196245 no 194 0.0132734487971029 182 124049 Also referred to as licorice root. SGTC_733 4069-0007 56.1 µM 2.20828722660688 0.0230430233015835 no 195 0.0136121285915541 272 5717425 YNL287W SEC21 SGTC_58 0957-0393 9 µM 2.20288156549123 0.0233046085728142 no 196 0.0138015486245968 634 6997992 SGTC_1031 k035-0009 16 µM 2.18876824089837 0.0239993708709504 no 197 0.0143068445849104 203 5180959 SGTC_823 0417-1665 178 µM 2.18686453186557 0.0240944043766544 no 198 0.0143762074162859 186 3429856 SGTC_2619 obliquin 87.91 µM 2.18657425971354 0.024108922556847 no 199 0.0143868090653415 338 6708593 A bioactive alkalod. YER133W GLC7 SGTC_1094 duloxetine 25.4 µM 2.18273282613752 0.0243017479150599 no 200 0.0145277455236018 184 60834 A selective serotonin reuptake inhibitor. SGTC_889 0919-1524 82.7 µM 2.18157890282063 0.0243599227959692 no 201 0.0145703126622384 158 3905452 SGTC_224 benfluorex 43.875 µM 2.1744450687662 0.0247221755900606 no 202 0.014835863261775 94 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis. SGTC_2104 5389443 200 µM 2.17382434140433 0.0247539084530066 no 203 0.0148591648756556 200 2244536 SGTC_1845 st056753 3.01 µM 2.1723927267236 0.0248272258406423 no 204 0.0149130265766076 208 5375839 SGTC_550 4123-0385 25.7 µM 2.16880796427099 0.0250116119009591 no 205 0.0150486331720804 186 5731123 SGTC_458 nppb 133 µM 2.16752913806652 0.0250776669048501 no 206 0.0150972651936644 145 4549 A chloride channel blocker. SGTC_3003 9075612 71.4286 µM 2.16725070963115 0.0250920678918923 no 207 0.0151078713328247 181 6501993 SGTC_2694 st077685 81.9 µM 2.16656549023202 0.0251275386079167 no 208 0.0151340005797811 201 2838096 SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM 2.16192804059476 0.0253687047371295 no 209 0.0153118616220636 265 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_1068 loratadine 26.9 µM 2.15841498083004 0.0255526861794304 no 210 0.0154477910092271 173 3957 A H1 histamine antagonist. SGTC_835 0312-0010 67.2 µM 2.15172310186303 0.0259062362119076 no 211 0.0157095847529151 151 1626196 SGTC_3079 9117512 49.47 µM 2.13911283047155 0.0265835965767959 no 212 0.016213265769376 83 7185044 SGTC_2030 5175110 200 µM 2.13596950306136 0.0267547251210427 no 213 0.0163409498405478 164 2831986 SGTC_2401 5128683 200 µM 2.1306653224488 0.0270455801167016 no 214 0.0165583619384346 197 708373 SGTC_1589 2',5'-dimethoxyflavone 47.2 µM 2.13057389249319 0.0270506167265014 no 215 0.0165621311456013 208 688667 SGTC_1188 1403-0014 4.57 µM 2.12890467666665 0.0271427066448458 no 216 0.0166310738919662 261 9614867 SGTC_2682 pyrogallin 40.03 µM 2.12761717503527 0.0272139161223425 no 217 0.016684418522463 223 822798 An ATP competetive kinase inhibitor. SGTC_3244 9134489 49.47 µM 2.1243908012477 0.027393046132399 no 218 0.0168187392774879 183 16584271 SGTC_360 0957-0399 1.01 µM 2.11990401177009 0.0276437886481106 no 219 0.0170070705094419 225 6752301 YPR165W RHO1 SGTC_1777 st045864 34.765 µM 2.11826514339946 0.0277358518775837 no 220 0.0170763094478886 164 4691462 SGTC_756 0508-1999 28.3 µM 2.11786567705496 0.0277583305362245 no 221 0.0170932225816641 178 6753853 SGTC_2581 avocatin a 64 µM 2.10798759429512 0.028319034291406 no 222 0.0175160312633094 234 6710728 A skin care supplement. SGTC_367 0335-0881 7.1 µM 2.10503471104793 0.028488465763239 no 223 0.0176441433350643 256 23828853 SGTC_507 nimesulide 162 µM 2.09874589055244 0.0288521192825017 no 224 0.0179196534912241 184 4495 A COX2 inhibitor. SGTC_1494 4358-1428 177 µM 2.09772535963208 0.0289114942416716 no 225 0.0179647066692628 190 1564571 SGTC_1131 3454-3128 32.3 µM 2.09409767274548 0.0291233774779671 no 226 0.0181256401776342 245 710982 SGTC_693 4161-2696 114 µM 2.09109824553881 0.0292995386409068 no 227 0.0182596289813942 130 805759 SGTC_3355 9151058 44.0485 µM 2.08474230355287 0.0296757586969872 no 228 0.0185463492266704 179 17015728 SGTC_1403 3909-7815 62.9 µM 2.07860486922772 0.0300428406511392 no 229 0.0188268415368309 155 6615483 SGTC_2251 lansoprazole 556 µM 2.06765391296094 0.0307071713944068 no 230 0.0193362892741833 160 3883 Gastric proton pump inhibitor. YBR192W RIM2 SGTC_2654 protoveratrine a 100 µM 2.0651180558181 0.0308627292661477 no 231 0.0194559157045738 170 5702278 A heart drug and vasodilator. SGTC_982 1491-0518 27.5 µM 2.05623480043605 0.0314128106153684 no 232 0.0198799446990278 175 3091256 SGTC_731 3966-0296 387 µM 2.0561881094269 0.0314157231571782 no 233 0.0198821939793673 193 660956 SGTC_558 k064-0027 21.3 µM 2.04955143280974 0.0318319899918304 no 234 0.0202041119697408 213 5088526 SGTC_2906 7926292 26.41 µM 2.04830173214516 0.0319108814689727 no 235 0.020265221689802 223 2966319 SGTC_1161 k007-0610 110 µM 2.04383468162992 0.0321942001242887 no 236 0.0204849408513121 345 5843850 SGTC_1677 st019204 53.9 µM 2.03830220120079 0.0325479676761043 no 237 0.020759859944474 213 3945625 SGTC_794 k038-0031 316 µM 2.03814985012158 0.0325577547601732 no 238 0.0207674745363729 316 6624242 SGTC_2070 5230947 200 µM 2.03778193513102 0.0325813997510937 no 239 0.0207858728848225 189 2835538 SGTC_3316 9136639 10.545 µM 2.03438401820596 0.0328004456401409 no 240 0.0209564459756195 177 4903665 SGTC_2722 naftopidil 47.16 µM 2.02872421967525 0.0331679976273855 no 241 0.0212431937937248 192 4418 An a1-adrenergic receptor antagonist or alpha blocker.  SGTC_1992 st073643 23.3 µM 2.028119010188 0.0332075004524385 no 242 0.0212740515781009 173 3161292 SGTC_1136 pergolide 1.05886 µM 2.02521410181342 0.0333976474503821 no 243 0.0214226921351877 310 47811 A dopamine receptor agonist. SGTC_130 0136-0219 337.655 µM 2.01969830268581 0.0337611630970031 no 244 0.021707345638063 219 234244 SGTC_1949 st076024 69.1 µM 2.00879856611813 0.0344890779509619 no 245 0.0222792501969629 229 2921930 SGTC_1922 5578187 25 µM 2.00825855858245 0.0345254738177056 no 246 0.0223079115922461 244 1350412 SGTC_870 0573-2213 57.6 µM 2.00734360441913 0.034587212658718 no 247 0.022356544623252 181 3916321 SGTC_552 k242-0005 476 µM 1.99918433166795 0.0351417999258448 no 248 0.0227942066054233 192 4088318 SGTC_380 3970-0968 6 µM 1.98786873329584 0.0359229783947924 no 249 0.0234131047779405 209 2891601 SGTC_960 1222-0186 7.7 µM 1.98507791614834 0.0361178153232089 no 250 0.0235679016886501 239 3126296 SGTC_3282 9108498 15.4605 µM 1.98184373223474 0.0363446868571529 no 251 0.0237483665766103 235 16459645 SGTC_2867 9039098 71.43 µM 1.9703359454344 0.0371614118315856 no 252 0.0243999407031768 252 6463460 SGTC_172 1112-0046 2.638 µM 1.96919149687593 0.0372434486019712 no 253 0.0244655524834411 196 2802135 YIL048W NEO1 SGTC_1909 st060837 51.5 µM 1.9656766753671 0.0374963247621114 no 254 0.024667985394051 255 678937 SGTC_2948 9070189 9.45 µM 1.95572067090375 0.03822023507114 no 255 0.0252490341568626 225 6473636 YDL196W YDL196W SGTC_1030 k029-0042 36.7 µM 1.95337027644173 0.0383927869298279 no 256 0.0253878678217207 274 6080581 SGTC_2967 9089538 49.85 µM 1.9527418957313 0.0384390263012475 no 257 0.0254250933096102 256 728216 SGTC_751 0833-0568 350 µM 1.95180682091883 0.0385079177700727 no 258 0.0254805720850751 221 6954252 SGTC_2771 fluoxetine 41.05 µM 1.95050260596788 0.0386041735948545 no 259 0.0255581215412042 208 3386 A selective serotonin reuptake inhibitor. SGTC_1773 st048542 73.5835 µM 1.94103412839385 0.0393088744207262 no 260 0.0261270689570037 272 3237138 SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM 1.93901740119339 0.0394603154757832 no 261 0.026249609658239 274 6708561 SGTC_1468 k284-1086 134 µM 1.93864444449569 0.0394883736555729 no 262 0.0262723238775568 308 15996457 SGTC_1222 0366-0074 1.18 µM 1.93802612187269 0.0395349268941621 no 263 0.0263100178440102 222 286520 SGTC_1514 1189-1591 158 µM 1.91761515910733 0.0410968848373846 no 264 0.027579913270614 301 767698 YMR146C TIF34 SGTC_1108 betulinic acid 729.144 nM 1.90780242696399 0.0418654246544094 no 265 0.0282083784909174 241 64945 Apoptosis-inducing agent of unknown mechanism. SGTC_3076 9116187 49.47 µM 1.90525721952296 0.042066656321279 no 266 0.0283733217663347 212 27241210 SGTC_1314 1222-0010 41.1 µM 1.90142596361837 0.0423710422807749 no 267 0.0286231207189035 225 3526027 SGTC_3350 9150499 3.57 µM 1.89757697174274 0.0426786288857833 no 268 0.0288759151685135 316 4910996 YPR165W RHO1 SGTC_1294 1000-1494 117 µM 1.89675935193053 0.0427441996878016 no 269 0.0289298531811654 242 712797 YDL207W GLE1 SGTC_206 4546-0025 72.014 µM 1.88970987429092 0.0433129318459652 no 270 0.029398386382853 320 6620745 YIL048W NEO1 SGTC_2322 7413319 38.22 µM 1.8876732644757 0.0434783726803841 no 271 0.0295349138525356 463 1840400 SGTC_41 0478-0632 82.643 µM 1.87762522742077 0.0443020903390776 no 272 0.0302162260597819 306 3750424 SGTC_352 k048-0007 5.11 µM 1.87600491597918 0.0444360902562116 no 273 0.030327302430997 320 6811911 SGTC_330 1488-0319 80.1 µM 1.87597546743993 0.0444385286716156 no 274 0.0303293243279874 238 6846614 SGTC_305 1682-2595 20.8 µM 1.87570702768993 0.0444607611499858 no 275 0.0303477601897263 249 226033 SGTC_1669 st015249 58.4 µM 1.87551370328305 0.0444767780425879 no 276 0.0303610430432093 213 722793 SGTC_2426 5582046 32.21 µM 1.87340271448499 0.0446519757870846 no 277 0.0305063977321969 280 2251934 SGTC_767 0929-0023 86 µM 1.85552821572015 0.0461578142334353 no 278 0.0317604169186793 380 1204563 SGTC_1080 nisoldipine 24.4 µM 1.83782373279667 0.0476892686936764 no 279 0.0330441916504377 282 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class. SGTC_2980 9014342 25.29 µM 1.83558180275265 0.0478860674451591 no 280 0.0332097652549076 279 2996599 SGTC_3028 9087778 49.47 µM 1.82783766238332 0.0485708615212472 no 281 0.033786959487437 239 17217395 SGTC_1681 tripelennamine 100 µM 1.82614883610926 0.0487212350209351 no 282 0.0339139228590643 228 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist. SGTC_1350 1495-0454 146 µM 1.82583995175119 0.0487487783707572 no 283 0.0339371867095354 315 1069057 SGTC_544 k015-0020 52.4 µM 1.8177114629316 0.0494780825537837 no 284 0.0345541224036022 267 3008304 SGTC_191 3914-0123 66.505 µM 1.81626775642803 0.0496085209257962 no 285 0.0346646544058625 145 3144412 SGTC_3315 9136395 68.55 µM 1.81577858962509 0.0496527791625452 no 286 0.0347021714353231 275 16876844 SGTC_3286 9117135 37.221 µM 1.81447418948143 0.0497709511189424 no 287 0.0348023764544514 277 3438150 SGTC_1868 st057644 42.7 µM 1.81159695874745 0.0500324067309393 no 288 0.0350242476069077 315 688665 SGTC_387 norethindrone acetate 66.7 µM 1.80939543230437 0.050233199346062 no 289 0.0351947961431607 261 541197 SGTC_2723 salbutamol 83.58 µM 1.80315780273112 0.0508055986610777 no 290 0.0356817177012915 160 9884233 β2-adrenoceptor agonist SGTC_613 3914-0030 117 µM 1.79493052700106 0.0515685077181001 no 291 0.0363323847353294 78 1145395 SGTC_304 1310-0298 97 µM 1.79314172601798 0.0517355814344413 no 292 0.0364751325848128 358 1550234 SGTC_2903 5923464 63.88 µM 1.78696737632641 0.0523155724581181 no 293 0.0369713807640433 233 2876576 SGTC_1239 0337-0584 35.4 µM 1.7861199389212 0.0523955783470861 no 294 0.0370399202070898 375 914301 YML130C ERO1 SGTC_2823 7987624 58.44 µM 1.78454052857948 0.0525449484210852 no 295 0.0371679376499907 340 2239440 SGTC_511 blebbistatin 171 µM 1.77531611192993 0.0534240946967208 no 296 0.0379228532630149 286 3476986 A myosin inhibitor. SGTC_1970 st070122 35.8 µM 1.77050778249419 0.0538869590706579 no 297 0.0383212945439946 319 102928 SGTC_596 1155-0152 116 µM 1.77002883355584 0.0539332375066992 no 298 0.038361168785424 364 280313 SGTC_354 2783-3500 4.88 µM 1.76764904896285 0.0541636509366139 no 299 0.0385597963674941 333 6740761 SGTC_1674 st016616 23.6 µM 1.76748361900123 0.0541796969662891 no 300 0.0385736349982202 313 625830 SGTC_1077 5-fluorocytosine 377 nM 1.76611212680705 0.0543128710130801 no 301 0.038688519683678 280 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_688 0527-0193 473 µM 1.76263307876404 0.0546518538732083 no 302 0.0389811971415229 257 4007154 SGTC_2775 cyproheptadine 69.59 µM 1.76162801915003 0.0547500931886385 no 303 0.0390660833516949 276 2913 A selective serotonin reuptake inhibitor. SGTC_141 0443-0274 32.331 µM 1.75971652629154 0.0549373167889586 no 304 0.0392279411526024 438 1627241 SGTC_2919 7978188 46.38 µM 1.74941447603873 0.0559550904910177 no 305 0.0401097001890319 305 2980291 SGTC_1676 st018489 23.4 µM 1.7447650047458 0.0564192715137958 no 306 0.0405128913630029 338 3696235 SGTC_2495 cafestol 54.53 µM 1.74401551322643 0.0564943804056999 no 307 0.0405781923942901 299 16667697 An anti-infammatory. SGTC_2813 7971799 71.43 µM 1.7429675278482 0.056599534393782 no 308 0.040669643560918 285 2234054 SGTC_3056 9094900 49.47 µM 1.74263444556908 0.056632987871124 no 309 0.040698744585439 323 25236784 SGTC_59 0330-0160 1.33 µM 1.74016220823156 0.0568817768353684 no 310 0.0409152697430702 489 4293482 SGTC_1242 0402-0103 60.1 µM 1.73791185399252 0.0571089845445986 no 311 0.0411131733183445 285 432868 SGTC_1626 st003712 1.76 µM 1.73583240965495 0.0573195707928994 no 312 0.0412967358571945 288 24207035 SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM 1.73142261169387 0.0577681745630485 no 313 0.0416882082797345 280 2724278 An inhibitor of dopamine biosynthesis. SGTC_2748 diazoxide 86.69 µM 1.72716245430085 0.0582041726181241 no 314 0.0420692458671694 235 3019 A potassium channel activatior. SGTC_3285 9112818 20.8695 µM 1.72689329056874 0.0582318062846756 no 315 0.0420934148159412 332 17017947 YPR165W RHO1 SGTC_2689 tacrolimus 100 µM 1.72593015820689 0.0583307705981743 no 316 0.0421799891737098 336 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). SGTC_2072 5231554 129 µM 1.71763390752336 0.0591887104420407 no 317 0.0429317057676851 282 789545 SGTC_236 1509-0011 5.31 µM 1.71609251098849 0.059349195523276 no 318 0.043072555859368 661 3107280 SGTC_1759 st043059 70 µM 1.70848376441824 0.0601463966844164 no 319 0.043773308194786 356 669426 SGTC_1951 sophoraflavanone G 9.2 µM 1.7068892216416 0.0603145215709937 no 320 0.043921322274771 345 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity. SGTC_1912 st060209 90.8 µM 1.70649946565876 0.0603556724256805 no 321 0.043957562856959 321 688787 SGTC_46 0329-0187a 2.197 µM 1.7055975159553 0.0604509855002126 no 322 0.0440415210994841 433 46494817 SGTC_668 1682-0499 62.6 µM 1.69745408043485 0.0613168794668372 no 323 0.0448054227922994 389 682214 SGTC_1017 4239-0030 168 µM 1.69531435847665 0.0615459967669789 no 324 0.0450079012073441 366 1149593 SGTC_35 0133-0054 64.071 µM 1.68932405864544 0.0621909831753226 no 325 0.0455786726460186 322 99677 SGTC_852 0418-0143 439 µM 1.68503741123139 0.0626557619541016 no 326 0.0459906769032029 411 5369229 SGTC_1550 gossypolone 36.6 µM 1.68465442469583 0.0626974185790597 no 327 0.046027632179314 353 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_677 0929-0063 136 µM 1.6820415954596 0.0629821866024657 no 328 0.0462803871789451 252 1539583 SGTC_2108 5365811 200 µM 1.68099311473159 0.0630967416873654 no 329 0.046382125975673 347 780283 SGTC_1431 4049-0260 9.09 µM 1.67951098326237 0.0632589534020965 no 330 0.0465262500667669 322 3854841 SGTC_1326 1431-2094 10.8 µM 1.67389556240673 0.0638764794148454 no 331 0.0470755632447025 370 616278 SGTC_1940 st075990 51.1 µM 1.67305171190449 0.0639696812182046 no 332 0.0471585582029506 375 1084979 SGTC_2594 a-mangostin 100 µM 1.66991183186166 0.0643174044596623 no 333 0.0474684045196797 378 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis. SGTC_2305 7443522 69.23 µM 1.66649727276941 0.0646972121384452 no 334 0.0478072054718744 338 5415886 SGTC_2889 9059656 51.95 µM 1.66589109804363 0.0647648197538336 no 335 0.047867553497592 348 3949838 SGTC_2881 9058953 51.95 µM 1.66039940069981 0.0653798196925403 no 336 0.0484170653167794 378 17122249 SGTC_700 3453-2283 142 µM 1.65564790714568 0.0659155730301919 no 337 0.0488965712047661 392 565664 SGTC_2537 larixol 68.93 µM 1.65525577665605 0.0659599391231819 no 338 0.0489363126953025 359 6708759 SGTC_1605 st000082 49.1 µM 1.65486114139294 0.0660046119669643 no 339 0.048976334090077 316 1114022 SGTC_1061 3448-9325 110 µM 1.65362561945343 0.0661446250602447 no 340 0.0491018019687863 293 723482 SGTC_956 1185-0240 191 µM 1.64980251818442 0.0665793281059766 no 341 0.0494916667871424 339 1416193 SGTC_1611 st001856 99.4 µM 1.64792091797466 0.0667940845344056 no 342 0.0496844501539768 340 647478 SGTC_2432 5630864 12.22 µM 1.64109067318943 0.0675781607757333 no 343 0.0503892972651095 344 5714970 SGTC_709 3807-1509 243 µM 1.63850265222223 0.0678771030040853 no 344 0.0506584406179695 282 1886677 YPL242C IQG1 SGTC_727 3032-0951 202 µM 1.63832040417331 0.0678981929006741 no 345 0.0506774367231287 336 3652836 SGTC_1410 3909-8106 77.9 µM 1.63026445636165 0.0688354987380496 no 346 0.0515228081316035 310 1039210 SGTC_792 4534-1957 155 µM 1.62881572034579 0.0690051118090409 no 347 0.0516760178825618 325 1717904 SGTC_1537 2',6'-dihydroxyflavanone 78 µM 1.62573831413136 0.0693664726972561 no 348 0.052002667880407 390 5106787 A p450 inhibitor. SGTC_873 0591-4978 488 µM 1.62479674899964 0.0694773256095166 no 349 0.0521029370010126 374 3305145 SGTC_55 0767-0285 6.563 µM 1.62015593039585 0.0700256955837795 no 350 0.0525993926976497 420 3116166 SGTC_21 0849-0113 22.993 µM 1.61839320894207 0.070234853308253 no 351 0.052788942307778 379 1560156 SGTC_2511 berberine 10.47 µM 1.6179756332626 0.0702844715468906 no 352 0.0528339245081522 329 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_368 fentichlor 4.58 µM 1.6160798156261 0.0705100802779981 no 353 0.0530385288087243 316 7329 A pesticide. SGTC_2884 9058502 51.95 µM 1.61494893852304 0.0706449233257955 no 354 0.0531608765109453 376 6471554 SGTC_1737 st035557 69.7 µM 1.60462791213879 0.0718847511110048 no 355 0.0542878574861565 309 5716916 SGTC_1263 0774-1208 64.8 µM 1.59482656865786 0.073077533755776 no 356 0.0553755119959949 446 906585 SGTC_1285 0929-0069 65.5 µM 1.59131796676171 0.0735081778875293 no 357 0.0557690176937631 379 1206237 SGTC_905 2-aminofluorene 215 µM 1.59096246752229 0.0735519197444017 no 358 0.0558090113556746 401 1539 An established DNA mutagen. YPR165W RHO1 SGTC_3185 9108267 49.47 µM 1.58908719280542 0.0737829895029993 no 359 0.0560203544080311 388 4910486 SGTC_2525 harmine 47.85 µM 1.58633064142367 0.0741236561065859 no 360 0.0563321624734662 297 5280953 A monoamine oxidase inhibitor SGTC_3092 9117248 49.47 µM 1.58126351648096 0.0747530058709827 no 361 0.0569088988929636 323 17141857 SGTC_1531 st059297 52.4 µM 1.57770571591115 0.0751973244578193 no 362 0.0573166162753717 387 7566702 SGTC_1286 0929-0070 131 µM 1.57573225419251 0.0754446483916572 no 363 0.057543760422709 412 1420408 SGTC_455 paf C-16 10 µM 1.56441438975902 0.0768750465318026 no 364 0.058860141770639 364 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis. SGTC_2061 5245884 80.95 µM 1.56166678825694 0.0772253900558176 no 365 0.0591832533169788 403 573863 SGTC_517 1365-0151 113 µM 1.55200323413658 0.0784672181188704 no 366 0.060330724881648 385 768657 SGTC_1879 gemcitabine 100 µM 1.54776885235363 0.0790161093997411 no 367 0.0608389791035266 384 60750 A nucleoside analog which inhibits DNA replication. SGTC_1925 st057770 10.1 µM 1.53841993267499 0.0802382757669944 no 368 0.0619729858319863 374 5989122 SGTC_1493 4348-0038 111 µM 1.53712895282011 0.0804081596946341 no 369 0.0621308670916899 436 800424 SGTC_2617 dihydrotanshinone i 20.83 µM 1.53663801258775 0.0804728352746407 no 370 0.0621909892494307 443 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12 SGTC_1444 4112-3581 28 µM 1.53597594818118 0.0805601166706737 no 371 0.0622721396933861 382 2877249 SGTC_1290 0986-0249 10.2 µM 1.53557559326933 0.0806129310159434 no 372 0.0623212519829559 359 53329 SGTC_1331 1472-0049 76.2 µM 1.53498349022874 0.0806910884798634 no 373 0.062393941743243 400 24051409 SGTC_880 0833-0487 87.2 µM 1.53495797746448 0.0806944574443749 no 374 0.0623970753127622 410 76075 SGTC_832 4083-0019 164 µM 1.53465778342139 0.0807341060932455 no 375 0.0624339554431014 603 1990758 SGTC_2776 terbinafine 19.92 µM 1.53404406821903 0.0808152093698327 no 376 0.062509405888392 417 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_1956 st077085 54 µM 1.53336732230386 0.0809047135379856 no 377 0.0625926877523007 447 24208685 SGTC_2011 4012611 177 µM 1.53221503816805 0.0810572829635053 no 378 0.0627346893908858 422 2049887 SGTC_3227 9130768 49.47 µM 1.53138894280991 0.0811667965790493 no 379 0.0628366476034493 341 17720899 SGTC_127 0180-0333 59.125 µM 1.529686067129 0.0813928952180035 no 380 0.0630472270036054 511 771601 SGTC_1056 3448-1962 115 µM 1.52890868285213 0.0814962699032683 no 381 0.0631435417139824 378 715507 SGTC_721 1187-1332 279 µM 1.52749177616064 0.0816849413852583 no 382 0.0633193853196708 297 25730 SGTC_2414 st077232 92.9 µM 1.52589937788915 0.0818973736364691 no 383 0.0635174628300391 401 729801 SGTC_2045 5106652 78.05 µM 1.52036948585187 0.0826383169353015 no 384 0.0642090695505171 388 673349 SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM 1.52007677364034 0.082677677217855 no 385 0.0642458406502212 434 2333 A French combination drug. SGTC_1213 1315-0166 115 µM 1.51694555928525 0.0830996069108925 no 386 0.0646402148089431 362 768401 SGTC_1906 st060206 94.7 µM 1.51646828900017 0.0831640608296483 no 387 0.0647004914408497 434 5133468 SGTC_1765 st044815 90.4 µM 1.51100181930535 0.0839049742227994 no 388 0.0653939936745616 418 645695 SGTC_2793 7325131 81.82 µM 1.50771931162582 0.0843522539294003 no 389 0.0658131904027368 375 4176441 SGTC_1399 3562-5772 25 µM 1.50535543861596 0.0846754655450903 no 390 0.0661163595798013 338 23847490 SGTC_3331 9141060 1.957 µM 1.50427407825236 0.0848236288621683 no 391 0.0662554053169459 403 4906567 YPR165W RHO1 SGTC_3356 9151811 4.48 µM 1.49723925069043 0.0857922593992491 no 392 0.0671655078108452 408 1859254 YPR165W RHO1 SGTC_2260 7964312 200 µM 1.49593504835902 0.0859727421599115 no 393 0.0673352909378592 384 231951 SGTC_2418 pentamidine 31.67 µM 1.49213821187158 0.0864997869054094 no 394 0.0678314581427361 414 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_1502 4534-4282 27.7 µM 1.48301920733194 0.0877754718557358 no 395 0.0690346538511372 379 3278949 SGTC_1778 st046819 58.9 µM 1.48175677912098 0.087953176953855 no 396 0.0692025115788904 496 671715 SGTC_1357 1503-1303 39.5 µM 1.47935426980246 0.088292105913806 no 397 0.0695228277178932 491 292895 SGTC_3281 9140613 49.47 µM 1.47724801682724 0.0885900410479861 no 398 0.0698045834105665 382 16013766 SGTC_1863 st057641 20.1 µM 1.47377946756115 0.0890823077268418 no 399 0.0702704891611763 466 3921635 SGTC_2610 ononetin 44.17 µM 1.47323798848279 0.0891593393832489 no 400 0.0703434375307325 485 259632 SGTC_2595 hexamethylquercetagetin 100 µM 1.47235358491146 0.0892852625937078 no 401 0.0704627100887158 413 386331 SGTC_1289 0976-0073 69.1 µM 1.46514985383077 0.0903158766631063 no 402 0.0714400187588777 451 3391136 SGTC_355 1311-2252 105 µM 1.46250308890886 0.0906967516690917 no 403 0.0718016992570082 462 5338538 SGTC_3320 9137005 35.139 µM 1.46013745355483 0.091038179276145 no 404 0.0721261504692921 431 4908713 SGTC_426 0988-0037 14.6 µM 1.45725246382108 0.0914558534408292 no 405 0.072523351682713 515 5383008 SGTC_672 1441-0018 53.7 µM 1.45658107594323 0.0915532569761327 no 406 0.0726160272879763 416 251141 SGTC_821 1114-0266 29.2 µM 1.45145851265415 0.0922989597949422 no 407 0.0733261133231763 430 3123235 SGTC_542 3381-0244 89.3 µM 1.4508333811022 0.0923902684499384 no 408 0.073413131003137 519 1112843 SGTC_1362 1611-0397 101 µM 1.4492334799961 0.0926242593890231 no 409 0.0736361953335765 453 27816 SGTC_2232 chlorophetanol 41.5365 µM 1.44298032302432 0.0935430099843213 no 410 0.0745130071475382 600 15907 An antifungal of unknown mechanism. YFR051C RET2 SGTC_1180 1193-0155 285 µM 1.44166463232653 0.0937371730860893 no 411 0.0746985028161728 448 2921347 SGTC_698 k064-0052 127 µM 1.43682436457833 0.0944540365547685 no 412 0.0753839527549647 378 5088751 SGTC_2904 7225135 42.03 µM 1.43611870523798 0.0945588843084874 no 413 0.0754842831664097 462 4446116 SGTC_1806 st050005 60.3 µM 1.43402688022896 0.0948701944164464 no 414 0.0757822960960807 460 5194765 SGTC_590 k048-0076 22.4 µM 1.42804291699483 0.0957649102237046 no 415 0.076639753038858 457 6832814 SGTC_3016 9080866 49.47 µM 1.42614384461704 0.0960501510405408 no 416 0.0769134125538126 484 17066299 SGTC_2140 5586273 200 µM 1.42392467107876 0.0963842620191101 no 417 0.0772341396153252 406 854421 SGTC_1245 0418-0076 17.2 µM 1.42254501823886 0.0965924077878302 no 418 0.0774340461674183 472 6790114 SGTC_652 0437-0092 114 µM 1.41703833044039 0.0974264813768401 no 419 0.0782358605571889 422 3091274 SGTC_2893 9048488 25.97 µM 1.4145236007546 0.0978091286602463 no 420 0.0786041114412852 444 6467338 SGTC_972 1319-0219 195 µM 1.4101692466173 0.0984743008915199 no 421 0.0792448571173372 489 23903702 SGTC_1840 st055363 71 µM 1.40932052242045 0.0986043370162374 no 422 0.079370206569455 410 676033 SGTC_1197 1601-0112 267 µM 1.40753652791314 0.0988780790146835 no 423 0.0796341768112343 519 7350313 SGTC_707 0865-0008 204 µM 1.4070935664604 0.0989461345699775 no 424 0.0796998227939164 469 723043 SGTC_384 k007-0144 5.16 µM 1.3989351536362 0.10020570761932 no 425 0.0809162148529765 540 6824886 SGTC_1465 k213-0056 144 µM 1.39860368266054 0.100257129553017 no 426 0.0809659307021847 466 24048857 YMR208W ERG12 SGTC_598 3937-0236 20.2 µM 1.398424937263 0.100284866772455 no 427 0.0809927494922516 545 1379313 SGTC_2812 7970281 58.44 µM 1.39742716118925 0.100439801819566 no 428 0.0811425780606183 493 2233435 SGTC_634 1611-4317 11.2 µM 1.39667751432005 0.100556322125916 no 429 0.0812552844514985 526 2843522 SGTC_1575 cyproterone acetate 48 µM 1.39579899311706 0.100692999296644 no 430 0.0813875168421016 483 9880 An androgen receptor antagonist and liver toxin. SGTC_674 0498-0004 451 µM 1.39344119157791 0.101060487280169 no 431 0.0817432084186522 482 4231473 SGTC_592 k241-0073 46.5 µM 1.39328552796149 0.101084783434978 no 432 0.0817667325818865 498 4230158 SGTC_907 3448-6986 75.5 µM 1.39213584497121 0.101264359113319 no 433 0.0819406327717532 540 590582 SGTC_229 benomyl 22.8748 µM 1.38247867344034 0.102781952148361 no 434 0.0834123871549886 520 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C SGTC_2956 9076196 2.52 µM 1.38234191113022 0.102803561943699 no 435 0.083433371502763 495 16423868 SGTC_379 3970-0972 5.9 µM 1.38214891776262 0.10283406241783 no 436 0.0834629905042912 485 2898042 YBL034C STU1 SGTC_165 k038-0023 64.381 µM 1.37861171127011 0.103394243995484 no 437 0.0840072518795382 544 46368543 SGTC_1368 1852-0141 284 µM 1.3766708254133 0.103702558485696 no 438 0.0843070213209817 480 2838987 SGTC_1652 st011932 78 µM 1.37412145670741 0.104108544700389 no 439 0.0847019896085497 475 1551076 SGTC_3088 9117578 49.47 µM 1.37230144346829 0.104399085412311 no 440 0.0849848082360606 469 678341 SGTC_744 1594-0068 283 µM 1.36932710724606 0.104875162227897 no 441 0.0854485241343807 546 668392 SGTC_2280 7785178 200 µM 1.36517380908364 0.105542572503622 no 442 0.0860992140570653 466 2954328 SGTC_1438 4092-1045 4 µM 1.36230377204232 0.106005561515391 no 443 0.0865510188590304 507 1351342 SGTC_303 1348-1668 34.2 µM 1.35531492007259 0.107139123968532 no 444 0.0876586216959333 477 5380509 SGTC_1521 st012942 49.4 µM 1.35447738258534 0.107275553384881 no 445 0.0877920622011063 554 24207259 SGTC_1341 1486-1360 280 µM 1.35127493511444 0.107798366287985 no 446 0.0883036890262247 519 3976547 SGTC_2194 5927483 104.545 µM 1.3504191311131 0.107938390107626 no 447 0.088440788811182 543 760979 SGTC_3020 9089140 49.47 µM 1.35023594466285 0.107968379479791 no 448 0.0884701558737693 502 17217859 SGTC_3083 9117465 49.47 µM 1.35016329848739 0.107980274014155 no 449 0.0884818039694197 520 16420915 SGTC_1002 4049-0206 172 µM 1.34811023913731 0.10831681662764 no 450 0.0888114643338945 563 4662749 SGTC_1429 4049-0205 9.46 µM 1.34355821892421 0.109065685825778 no 451 0.0895456439428201 531 22774478 SGTC_2304 7443016 91.4 µM 1.34031238171198 0.109601938013118 no 452 0.0900719038652283 455 939854 SGTC_819 1013-0258 27.7 µM 1.33982966293973 0.109681850517108 no 453 0.0901503647748459 523 5753198 SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM 1.3367230718436 0.110197137396269 no 454 0.0906565239830614 570 23847180 SGTC_2846 9008642 19.48 µM 1.33363422078835 0.110711200992813 no 455 0.0911618810502336 474 2992898 SGTC_2197 6588183 93.1375 µM 1.33324471517259 0.110776146475839 no 456 0.091225754855711 461 884136 SGTC_845 0330-0138 4.51 µM 1.33249343939251 0.110901489977252 no 457 0.0913490479372709 519 9039800 SGTC_1232 0279-0259 161 µM 1.33049481736953 0.11123543638744 no 458 0.0916776463982573 530 1560000 SGTC_641 4092-0595 30 µM 1.33028910318898 0.111269849646833 no 459 0.0917115180291245 543 786260 SGTC_3085 9117376 49.47 µM 1.32995277860561 0.111326128713537 no 460 0.0917669151336401 526 16480349 SGTC_86 0417-1630 471.922 µM 1.32915969525022 0.111458920440602 no 461 0.0918976445840341 661 3634867 SGTC_415 dibenzyl ketone 100 µM 1.32862271770224 0.111548894841482 no 462 0.0919862366088512 532 7593 SGTC_1015 4130-4525 82 µM 1.32782544091906 0.111682580075162 no 463 0.0921178901500792 531 1363237 SGTC_1966 st070145 16.1 µM 1.3273460951061 0.111763010645044 no 464 0.0921971111784282 523 3748532 SGTC_3074 9116018 49.47 µM 1.32325091244604 0.112451840386412 no 465 0.0928759749892139 471 17027303 SGTC_3102 9121669 49.47 µM 1.32314164956591 0.112470260385883 no 466 0.0928941381242254 476 41905072 SGTC_1990 st072050 59.8 µM 1.3225230343743 0.112574589806242 no 467 0.0929970221298118 532 17233948 SGTC_341 1486-1430 230 µM 1.31892627075266 0.113182553222992 no 468 0.0935968812273352 520 2054753 YPL210C SRP72 SGTC_1200 1643-0193 18.4 µM 1.31519452580354 0.113815804948469 no 469 0.0942222672308618 575 5403974 SGTC_3348 9149464 3.537 µM 1.3150772468777 0.113835747226561 no 470 0.0942419713034858 537 1951442 SGTC_2470 5664817 21.68 µM 1.31054502664087 0.114608320873772 no 471 0.0950057612120127 510 2859561 SGTC_2684 capsaicin 100 µM 1.30887373639703 0.114894152791099 no 472 0.0952885621996147 505 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_2955 9076254 12.21 µM 1.30807362822775 0.115031170389772 no 473 0.0954241686206644 501 16459619 SGTC_1548 st061468 90.8 µM 1.3054349660714 0.11548386162058 no 474 0.0958723892485968 547 390799 SGTC_838 0109-0203 71.4 µM 1.30327047166232 0.115856148187948 no 475 0.0962412191920521 551 759422 SGTC_7 0192-1582 4.227 µM 1.30255883187371 0.115978734057011 no 476 0.0963627101761571 659 252616 SGTC_1986 st071812 45 µM 1.30183741754251 0.116103097633025 no 477 0.0964859848686927 494 11838594 SGTC_2717 st081029 62.2815 µM 1.30099444375756 0.11624853655209 no 478 0.0966301782948225 503 5292846 SGTC_2082 5219693 150 µM 1.2990782170286 0.116579625462024 no 479 0.0969585438969507 559 2834649 SGTC_1297 1068-0111 14.1 µM 1.29388941955042 0.11747951017205 no 480 0.0978518098306183 526 767057 SGTC_1391 3442-0225 151 µM 1.29319614563077 0.117600114994209 no 481 0.0979716142054272 492 5227075 SGTC_276 colchicine 750 µM 1.29297803383722 0.117638076749838 no 482 0.0980093282327621 586 2833 A microtubule depolymerizer. SGTC_584 0986-0246 15.4 µM 1.29149925750436 0.117895682459574 no 483 0.098265306204224 606 53315 YDR232W HEM1 SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM 1.29025951273781 0.118111955759816 no 484 0.0984802845960596 528 5355888 SGTC_2791 5663188 71.43 µM 1.28845820031801 0.1184266942441 no 485 0.0987932551866087 511 54690634 SGTC_2604 4'-hydroxychalcone 11.32 µM 1.28659507890668 0.118752855652023 no 486 0.0991177299220863 527 5282362 SGTC_2371 9071574 200 µM 1.28623212582185 0.1188164686575 no 487 0.0991810311720257 483 45596039 SGTC_752 1896-0090 130 µM 1.28489277681637 0.119051418058605 no 488 0.0994148777067159 555 772567 SGTC_524 r073-0010 27.8 µM 1.28296755642941 0.119389715706094 no 489 0.0997517213841201 544 2772106 SGTC_289 k017-0060 526 µM 1.28121935840196 0.119697494306521 no 490 0.100058314210799 512 5512909 SGTC_2615 purpurogallin-4-carboxylic acid 100 µM 1.28021327168355 0.119874874134469 no 491 0.100235069795721 610 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase. SGTC_3211 9128781 49.47 µM 1.2787175217608 0.12013892729 no 492 0.100498273600738 558 17194361 SGTC_806 3966-4455 5.86 µM 1.2781907417436 0.120232020253063 no 493 0.100591089878131 492 714982 SGTC_2880 9042983 58.44 µM 1.2713743158505 0.1214412095842 no 494 0.101797757707755 578 6464714 SGTC_2644 guaiazulene 100 µM 1.26628374878105 0.122349801934394 no 495 0.102705756529181 536 3515 A coloring agent. SGTC_2731 amoxapine 43.43 µM 1.26613100618535 0.122377137803449 no 496 0.102733091723184 436 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine. SGTC_2833 9001315 45.46 µM 1.26377781687619 0.122798822596027 no 497 0.1031548927125 592 2989378 SGTC_2850 9015429 58.44 µM 1.26302909956145 0.122933204038934 no 498 0.103289361058683 529 6457570 SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM 1.26218819110592 0.123084255045272 no 499 0.103440538460061 632 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_681 1642-0006 26.6 µM 1.26194539321531 0.123127892626204 no 500 0.10348421820734 524 4446530 SGTC_36 0335-0881 14.2 µM 1.25922287395894 0.123617948160482 no 501 0.103974920883885 632 23828853 SGTC_1382 3002-2117 298 µM 1.25676716802355 0.124061147291686 no 502 0.10441897899098 611 1497314 SGTC_776 4476-4378 112 µM 1.25657112821786 0.124096575883496 no 503 0.104454487434814 551 2892008 SGTC_3134 9127454 49.47 µM 1.24332800900111 0.126506298696509 no 504 0.106873493472078 573 24262820 SGTC_1073 triclabendazole 3.09 µM 1.24302992720435 0.12656091029974 no 505 0.10692840275544 656 50248 An antihelmetic and likely tubulin inhibitor. SGTC_513 4245-1575 41.7 µM 1.24029222884431 0.127063252410754 no 506 0.107433662858082 724 719745 SGTC_3338 9144300 39.5675 µM 1.23817740345999 0.127452251890283 no 507 0.107825144111116 606 4901274 SGTC_1087 pterostilbene 9.05 µM 1.2363822073311 0.127783108257978 no 508 0.108158263329348 622 5281727 Similar to reservatol, lowers cholesterol. SGTC_2090 5301565 104.445 µM 1.2328947233153 0.128427559976868 no 509 0.108807522194773 655 2056344 SGTC_491 tetrandrine 80.3 µM 1.23186523777653 0.128618229051179 no 510 0.108999714365562 542 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_61 0978-8327 98.565 µM 1.23110314542701 0.128759501209546 no 511 0.109142144638059 617 6150059 YHR072W ERG7 SGTC_1953 st076800 12.1 µM 1.23070862458921 0.128832677416419 no 512 0.109215930621032 617 297591 SGTC_3109 9122853 49.47 µM 1.23067838860112 0.128838286814356 no 513 0.109221587040486 621 1234709 SGTC_2308 7584454 197.62 µM 1.22849434283858 0.129243920406448 no 514 0.109630725873449 648 893577 SGTC_214 4373-3496 70 µM 1.22668117460645 0.129581344318575 no 515 0.109971222998465 775 3779166 SGTC_2947 9072639 7.68 µM 1.22464701918919 0.129960618899552 no 516 0.110354122017878 648 16488146 SGTC_2236 dapsone 200 µM 1.22246363082313 0.130368572768404 no 517 0.110766174610966 621 2955 A bacterial DFR inhibitor. An anti-cancer agent. SGTC_2024 5144227 134 µM 1.22008073016842 0.130814814363892 no 518 0.111217136350297 645 3475211 SGTC_1260 0700-1617 7.75 µM 1.21724558320296 0.131347121196148 no 519 0.11175539582508 630 2853078 SGTC_2177 5811945 192 µM 1.21709291166575 0.131375828084675 no 520 0.111784433664205 604 5343475 SGTC_3178 9107506 49.47 µM 1.21415405850075 0.131929266176975 no 521 0.112344450089552 618 8897194 SGTC_1443 4112-3303 14 µM 1.2136188162264 0.132030234632695 no 522 0.112446659200773 620 704433 SGTC_3121 9125696 49.47 µM 1.2136125931265 0.132031408875674 no 523 0.112447847945723 569 1235365 SGTC_1905 st060207 84.5 µM 1.21320911404358 0.13210755712094 no 524 0.112524940227388 609 1948547 SGTC_1638 st008370 60.6 µM 1.20946475827345 0.132815670589512 no 525 0.113242171260425 626 24207134 SGTC_1786 berberine 21.6 µM 1.20895262776576 0.132912724914326 no 526 0.113340522793298 607 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_3023 9089636 49.47 µM 1.20836418315197 0.1330243018693 no 527 0.113453605188148 650 17249241 SGTC_1980 st071811 45.7 µM 1.20470672406957 0.133719250647483 no 528 0.114158269662002 604 4974850 SGTC_1695 st026914 34.495 µM 1.20379119159757 0.133893599606251 no 529 0.114335147539876 613 3289191 SGTC_8 0354-0001 70 µM 1.20337529278551 0.133972852667281 no 530 0.114415562252318 732 4993152 SGTC_1228 0124-0032 52.5 µM 1.19866010681912 0.134873626101066 no 531 0.115330068001744 636 X1228 SGTC_2923 7992654 58.14 µM 1.1965514980561 0.135277789126397 no 532 0.11574070736729 611 2985126 SGTC_2292 7671323 168.05 µM 1.19567851441055 0.135445359147907 no 533 0.115911019486401 619 937504 SGTC_993 3909-8757 62.7 µM 1.19494166289064 0.135586909141851 no 534 0.116054911739748 568 4288324 YLR208W SEC13 SGTC_1623 st003709 20.3 µM 1.19319404974397 0.135923032691911 no 535 0.116396692239692 696 16192618 SGTC_2224 6650123 117.647 µM 1.18866807225387 0.136796177580259 no 536 0.117285154597349 589 2908370 SGTC_534 k292-0788 63.4 µM 1.18663033107262 0.137190544640219 no 537 0.117686733259145 704 4146317 SGTC_678 1218-2179 85.9 µM 1.18113182559317 0.138258550696819 no 538 0.118775179370439 587 6820081 YOR116C RPO31 SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM 1.17764528967738 0.138938689393891 no 539 0.119469023215358 641 5711223 A potent inhibitor of glutathione S-transferases. SGTC_657 3534-0529 86.7 µM 1.17563207164234 0.139332455245031 no 540 0.119870966892653 637 1049549 SGTC_2469 5655019 90.81 µM 1.17428580937441 0.139596194272123 no 541 0.120140282668942 676 2788239 SGTC_2367 9070478 135.38 µM 1.17237533467709 0.139971047514738 no 542 0.120523198893819 662 572802 SGTC_3210 9128157 49.47 µM 1.1693151101887 0.140572916793841 no 543 0.121138348744975 589 17590849 SGTC_643 k048-0106 28.4 µM 1.16397232667856 0.141627913524699 no 544 0.1222176133491 657 6763920 SGTC_535 2293-4129 48.2 µM 1.15295560511239 0.143820193422893 no 545 0.124464303473327 742 396118 YIL048W NEO1 SGTC_60 0986-0278 202 µM 1.15223535587119 0.14396431293863 no 546 0.124612186355455 522 3110598 SGTC_433 pimozide 108 µM 1.15037937198074 0.144336138018458 no 547 0.124993826228793 538 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic SGTC_2088 5278280 127.392 µM 1.14508047581074 0.145401270493029 no 548 0.126087911207391 689 791502 SGTC_644 1498-1197 63.3 µM 1.14296603969417 0.145827765927489 no 549 0.126526345678351 705 6741615 SGTC_162 k030-0015 37.8 µM 1.14054595131743 0.146316944322173 no 550 0.127029460039319 690 1809920 YMR134W ERG29 SGTC_1964 st076914 61 µM 1.14006329330399 0.146414636806684 no 551 0.127129966550176 672 24208661 SGTC_1458 k015-0034 6.33 µM 1.13954962348564 0.146518654332064 no 552 0.127236991584321 631 3598957 SGTC_3052 9092717 49.47 µM 1.13916530886187 0.14659651001501 no 553 0.127317105959279 636 25237534 SGTC_2200 6600604 21.907 µM 1.13803928683934 0.146824782972919 no 554 0.127552038932431 692 2904777 SGTC_2660 2',4'-dihydroxychalcone 17.14 µM 1.13586415316193 0.147266412089934 no 555 0.128006711405435 666 5357218 A potent inhibitor of glutathione S-transferases. SGTC_333 3486-0131 40.1 µM 1.13541469889395 0.147357778094244 no 556 0.128100801909216 693 6744690 SGTC_2861 9024595 19.48 µM 1.13512180596984 0.147417338420023 no 557 0.128162143099356 554 16482810 SGTC_2882 9058044 58.44 µM 1.13294264118836 0.14786098210995 no 558 0.12861917076928 644 18076804 SGTC_555 4296-0685 37 µM 1.1325821520482 0.147934458107229 no 559 0.128694883625457 689 2908540 YHR072W ERG7 SGTC_1807 st050092 58.9 µM 1.13018643166248 0.148423382046885 no 560 0.129198837919637 659 5008496 SGTC_849 0386-0493 241 µM 1.13005322078147 0.148450599699019 no 561 0.129226899727475 648 726119 SGTC_3272 9137413 49.47 µM 1.12895855231823 0.148674388809453 no 562 0.129457659339893 648 17614870 SGTC_1420 4'-methoxyflavone 42 µM 1.12879753231196 0.148707326033224 no 563 0.129491626944669 695 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13 SGTC_844 0330-0132 15.3 µM 1.12860624895866 0.148746460072116 no 564 0.129531986708427 705 2828079 SGTC_1508 1080-0625 72.9 µM 1.12814269296412 0.148841326035538 no 565 0.129629830689645 638 767111 SGTC_2987 9018338 71.43 µM 1.1235256822089 0.149788396124105 no 566 0.130607149727697 693 5055682 SGTC_2701 st077767 14.721 µM 1.12285746901582 0.149925796441669 no 567 0.130749016598435 728 5721188 SGTC_954 1189-0853 2.85 µM 1.12078064723354 0.15035337617233 no 568 0.131190621912477 707 2828194 SGTC_2203 7227154 166.4 µM 1.11881822494513 0.150758149057518 no 569 0.131608847499835 646 896304 SGTC_275 trichlorophene 5.69 µM 1.11684666407044 0.151165536839769 no 570 0.132029946369282 822 62616 SGTC_416 estradiol valerate 100 µM 1.1161458120309 0.151310531662497 no 571 0.132179862549784 676 13791 A steroid. SGTC_2152 5568786 200 µM 1.11286811252808 0.151989861603538 no 572 0.132882538459328 676 5399883 SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM 1.10879460188405 0.152836949075333 no 573 0.133759399866425 662 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_96 0929-0093 37.281 µM 1.10599916799911 0.153420068207944 no 574 0.134363439744922 666 6991579 SGTC_1253 0550-0034 176 µM 1.10583835395016 0.153453658304992 no 575 0.13439824547519 657 5969915 SGTC_1196 1588-0294 184 µM 1.10529549749379 0.153567083631789 no 576 0.13451578413369 649 6144269 SGTC_101 0490-5701 117.494 µM 1.10189575874803 0.154278693008984 no 577 0.135253496340381 649 4661669 SGTC_372 0155-0182 15.9 µM 1.10012715580517 0.154649745432059 no 578 0.135638361714689 764 771486 SGTC_2508 celastrol 40.54 µM 1.09842683261178 0.155007028344012 no 579 0.136009075450297 639 122724 Celastrol is a natural product and antioxidant. SGTC_1217 1183-1422 255 µM 1.0975785581185 0.1551854769088 no 580 0.136194279982114 755 2849664 SGTC_710 3448-4187 58 µM 1.09693631851064 0.155320672800365 no 581 0.136334615481839 802 3946412 SGTC_1696 st025591 34.7925 µM 1.09376069414918 0.15599030584559 no 582 0.137029973548594 724 2787147 SGTC_3298 9116858 71.43 µM 1.09173332345816 0.156418804270653 no 583 0.137475166814734 742 2506942 SGTC_347 4534-1311 26.2 µM 1.09151569604526 0.15646484731463 no 584 0.137523014556249 705 2862016 SGTC_2787 5284540 71.43 µM 1.09124553731543 0.156522016730521 no 585 0.137582427690464 706 736958 SGTC_2553 4-methylesculetin 85.09 µM 1.09029366268833 0.156723556478006 no 586 0.137791902951304 707 5319502 SGTC_3118 9124250 49.47 µM 1.08857768021475 0.157087311540552 no 587 0.138170081908407 637 1504786 SGTC_2192 5915882 198.485 µM 1.08595883796967 0.15764352491916 no 588 0.13874860183605 664 2876149 SGTC_3301 9125354 19.7965 µM 1.08323265035821 0.158223910131982 no 589 0.139352585402773 645 41905162 SGTC_1528 arabinosylhypoxanthine 74.6 µM 1.08279939612959 0.158316275724771 no 590 0.13944873682884 772 804 An inhibitor of viral and cellular DNA polymerases. SGTC_2551 apiole 73.87 µM 1.08050751087967 0.158805471843896 no 591 0.139958121983007 576 10659 A possible DNA adduct former. SGTC_1430 4049-0248 69.1 µM 1.08027059940541 0.158856096341619 no 592 0.140010848988209 802 22774488 SGTC_614 0462-0418 107 µM 1.07859750105346 0.159213913933547 no 593 0.140383597901666 660 5188303 SGTC_1255 0566-0045 221 µM 1.07744589344722 0.159460509258673 no 594 0.140640555285511 724 2788469 SGTC_3328 9140624 29.0385 µM 1.07441481080976 0.160110753629774 no 595 0.141318403646521 763 4904392 SGTC_260 nsc-65238 3.989 µM 1.07267609542895 0.160484533673864 no 596 0.141708234680367 703 3246252 SGTC_834 0312-0008 75.7 µM 1.07100473165827 0.160844371771537 no 597 0.142083651057629 761 6385573 YIL048W NEO1 SGTC_2357 9067248 200 µM 1.07070153960634 0.160909704237516 no 598 0.142151825154935 685 9150235 SGTC_3163 9099914 49.47 µM 1.06926729073507 0.161218993982631 no 599 0.142474622499901 697 16268368 SGTC_747 3448-8087 38.7 µM 1.06201188979989 0.162789529864294 no 600 0.144115143778464 751 5168703 SGTC_2729 fluphenazine 10.66 µM 1.05931719109067 0.163375361709989 no 601 0.14472767416498 751 3372 An atypical antipsychotic. SGTC_2334 9017922 200 µM 1.05754921595969 0.163760465441324 no 602 0.145130502795153 768 3163164 SGTC_1601 4'-hydroxyflavanone 55.5 µM 1.05063537587795 0.165272103778961 no 603 0.14671304353002 803 165506 SGTC_470 aa-861 153 µM 1.05045612629828 0.165311414526439 no 604 0.14675422619496 773 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor. SGTC_3053 9095903 49.47 µM 1.050296671151 0.165346389294399 no 605 0.146790867598738 764 17174018 SGTC_1082 camptothecin 424.86 nM 1.05002983953985 0.16540492664117 no 606 0.146852196906059 653 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_2821 7996764 71.43 µM 1.04775320140713 0.165904919177505 no 607 0.147376164536357 778 2987135 SGTC_1006 4099-6547 255 µM 1.04738130978797 0.165986686290298 no 608 0.147461874180699 753 3146833 SGTC_3241 9133421 49.47 µM 1.04731584654905 0.166001082264924 no 609 0.14747696491136 746 17018221 SGTC_1141 3253-0389 52.6 µM 1.04546538630145 0.166408349387679 no 610 0.147903965114467 746 5402031 SGTC_2680 butyl paraben 22.24 µM 1.04217488330389 0.1671341471475 no 611 0.148665302792782 741 7184 An antifungal and steroid mimetic. SGTC_2929 9013348 24.6 µM 1.041794813237 0.167218111821067 no 612 0.148753409695215 713 2995952 SGTC_932 2857-0803 154 µM 1.03464772831625 0.168802099829827 no 613 0.150416727855921 815 674898 SGTC_3007 9078383 71.4286 µM 1.03359733752815 0.1690357049238 no 614 0.150662222300135 773 6496995 SGTC_3159 9100096 49.47 µM 1.03335139661781 0.169090431741797 no 615 0.150719741461792 734 25236875 SGTC_3243 9134147 49.47 µM 1.03059862144975 0.169703756075031 no 616 0.151364541410409 812 24282180 SGTC_2552 juarezic acid 87.02 µM 1.02902806556317 0.170054317822712 no 617 0.151733243368249 918 1549512 SGTC_1461 k072-0203 53.8 µM 1.02901284207578 0.17005771810733 no 618 0.151736820135457 732 5418714 SGTC_1104 tacrolimus 29.8 µM 1.02305167697227 0.171392539598961 no 619 0.153141706464942 817 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41 SGTC_269 exalamide 29 µM 1.02301601503371 0.17140054510334 no 620 0.153150136882601 755 3316 A derivative of salicylamide. SGTC_1726 st035556 14.5795 µM 1.02146529119252 0.171748887623853 no 621 0.153517022668703 824 5919439 SGTC_2071 5230951 39.92 µM 1.0184353258054 0.172430819341508 no 622 0.154235560704105 823 1799272 SGTC_2283 7944793 200 µM 1.01741977065224 0.172659768668025 no 623 0.15447689037132 773 2970533 SGTC_253 dyclonine 31.25 µM 1.01637956009002 0.172894477197549 no 624 0.154724337624031 845 3180 An oral anasthetic. SGTC_1888 azatryptophan 97.5 µM 1.01605103819201 0.172968645656687 no 625 0.154802541420624 712 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides SGTC_296 1222-0039 74.9 µM 1.01564833433723 0.173059589390649 no 626 0.154898439659218 732 5984176 SGTC_2721 ifenprodil 61.44 µM 1.01401571861769 0.173428599539676 no 627 0.155287625976091 778 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor. SGTC_3167 9103034 49.47 µM 1.00843069174425 0.174694732793439 no 628 0.156623872463967 735 5127859 SGTC_336 4111-0029 111 µM 1.00714509038706 0.174987009221976 no 629 0.156932527764289 724 3131175 SGTC_2172 5754775 163.918 µM 1.00429584148534 0.175635879864801 no 630 0.157618018742582 717 2263357 SGTC_1133 3473-0247 50 µM 1.00338063327257 0.175844626924099 no 631 0.157838622349677 765 711311 SGTC_1287 0971-0001 34.6 µM 1.00105625309249 0.176375493725978 no 632 0.158399806585178 829 4665869 SGTC_1772 st048439 82.2 µM 1.00098605043225 0.176391543119128 no 633 0.158416776227451 789 2927068 YDL195W SEC31 SGTC_2386 9075165 157.42 µM 0.997926289562698 0.177091948437576 no 634 0.159157551418367 799 16452277 SGTC_3045 9092950 49.47 µM 0.995871121639551 0.177563378853156 no 635 0.159656384128401 842 44120432 SGTC_595 3909-8003 73.7 µM 0.995613893401771 0.177622439589073 no 636 0.159718890823442 795 699517 SGTC_87 0100-0052 35.5 µM 0.995085828384497 0.177743724483547 no 637 0.159847261271415 1004 200187 YGR083C | YDR527W GCD2 | RBA50 SGTC_2007 4011539 71.82 µM 0.994238798943024 0.177938377562999 no 638 0.160053311581178 792 45595301 SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM 0.994167139134049 0.177954851635868 no 639 0.160070751674006 818 4213774 SGTC_226 1,3-diallylurea 8.28947 mM 0.993910099462734 0.178013951113153 no 640 0.160133318519587 772 74537 YKL182W FAS1 SGTC_291 SEC14.278 35.5 µM 0.993698101702744 0.178062703705142 no 641 0.160184933599705 823 1068044 SGTC_1235 benzylparaben 21.5 µM 0.993559968441144 0.178094474393038 no 642 0.160218570746649 763 7180 SGTC_2459 5811157 9.22 µM 0.991561740398805 0.178554467092642 no 643 0.160705680287401 820 2870684 YBR192W RIM2 SGTC_2686 alizarin 95.37 µM 0.990031840375987 0.178907155840806 no 644 0.161079278152814 748 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1 SGTC_2505 galangin 7.89 µM 0.988672943970065 0.179220790427164 no 645 0.16141159224095 732 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_2395 5646831 180.19 µM 0.986770397558421 0.179660480556841 no 646 0.161877604946175 810 6808628 SGTC_1221 2958-7315 257 µM 0.984437260809197 0.180200607182651 no 647 0.162450282538208 782 4562705 SGTC_3031 9088762 49.47 µM 0.982377742394485 0.18067823650619 no 648 0.16295689369442 863 205253 SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM 0.982102873094787 0.18074204228826 no 649 0.163024585096155 799 6710655 SGTC_871 0574-0004 149 µM 0.981348423618702 0.180917246253765 no 650 0.16321047547783 839 9551173 SGTC_2075 5212009 200 µM 0.981212919107373 0.180948725408169 no 651 0.163243877302271 731 780898 SGTC_126 0417-1624 672.48 µM 0.980228920737758 0.181177421758313 no 652 0.163486565854695 989 41912 YDL195W SEC31 SGTC_719 2810-4230 27.3 µM 0.98010295901247 0.181206710265699 no 653 0.163517649348273 797 721079 SGTC_1441 4106-0040 13 µM 0.97841183576487 0.18160021585214 no 654 0.163935338361203 828 2904180 SGTC_315 k915-0449 187 µM 0.973386547956179 0.182772696962079 no 655 0.165180611043694 914 20970215 YNL149C PGA2 SGTC_2234 tolnaftate 200 µM 0.97319024263525 0.182818593876985 no 656 0.165229379685654 807 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7 SGTC_493 zm226600 134 µM 0.970234821972859 0.183510451475741 no 657 0.165964728599749 833 5240098 A potassium channel opener. YCR052W RSC6 SGTC_667 1498-1044 59 µM 0.969334303276592 0.183721584919153 no 658 0.166189209660638 865 6739982 SGTC_1484 3473-2379 286 µM 0.968601585018802 0.183893487894038 no 659 0.166372006119357 983 671917 SGTC_980 1473-0395 201 µM 0.965833453682551 0.184543822605073 no 660 0.167063762847591 761 768876 SGTC_3066 9117245 49.47 µM 0.965033314149211 0.184732070633779 no 661 0.167264062956165 881 17176980 SGTC_290 2043-6722 48.1 µM 0.963747438757453 0.185034847227167 no 662 0.167586282158648 835 773758 YLR208W SEC13 SGTC_3264 9137442 49.47 µM 0.959479419626366 0.186042017660582 no 663 0.168658641305854 797 17015726 SGTC_397 arbidol 50 µM 0.95868312059269 0.186230304424465 no 664 0.168859202179342 900 131410 A RNA synthesis inhibitor. SGTC_2562 3',7'-dimethoxyflavone 64.92 µM 0.956364918062277 0.186779120782709 no 665 0.169443951192235 1007 688664 SGTC_264 promethazine 12.5 mM 0.953871423302191 0.187370552417137 no 666 0.170074365104743 997 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3 SGTC_3176 9106582 49.47 µM 0.953530920147902 0.187451406051132 no 667 0.170160568786894 728 17018027 SGTC_1627 st003713 25.6 µM 0.952854187025421 0.187612162641837 no 668 0.170331977430109 914 16195070 YER133W GLC7 SGTC_2531 methyl deoxycholate 70.07 µM 0.952576053224151 0.187678257457043 no 669 0.170402457552198 797 16667744 Haematoxylin. SGTC_618 k072-0232 33.2 µM 0.952453730115184 0.187707330477993 no 670 0.170433460588201 822 5872756 YGL099W LSG1 SGTC_2063 5246145 200 µM 0.947816109912272 0.188811623528664 no 671 0.171611538879115 877 711240 SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM 0.943014415981265 0.189959194201135 no 672 0.172836764629475 925 688788 SGTC_933 2914-0560 114 µM 0.940434244519963 0.19057760393592 no 673 0.173497431815207 933 463887 SGTC_2422 chlorphenesin carbamate 384.24 µM 0.938849282708058 0.190958096111414 no 674 0.173904065899461 878 2724 A muscle relaxant with antifungal properties. SGTC_2099 5377090 177.372 µM 0.938381117926907 0.191070574678541 no 675 0.174024293010851 839 2243829 SGTC_3078 9116413 49.47 µM 0.934921847373184 0.191902937673636 no 676 0.174914288530714 845 17177322 SGTC_3267 9137951 49.47 µM 0.93083255863238 0.192889752232449 no 677 0.175970092456161 869 16643986 SGTC_2031 5180455 200 µM 0.930381526766476 0.192998783317319 no 678 0.176086789910439 839 29949 SGTC_1608 st001473 40.5 µM 0.927330310789338 0.193737363124744 no 679 0.176877530709033 835 7292267 SGTC_1861 st057647 17.4 µM 0.926782111007678 0.193870243187852 no 680 0.177019837416707 884 688668 SGTC_723 4182-0001 115 µM 0.926395033071453 0.193964101813248 no 681 0.177120362203651 826 744821 YLR208W SEC13 SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM 0.924415106872653 0.194444627060615 no 682 0.177635116154538 841 6708514 SGTC_3140 9094243 49.47 µM 0.923182474235845 0.194744150909222 no 683 0.177956060224477 962 19291112 SGTC_2673 kobusone 100 µM 0.922918221686571 0.194808399533991 no 684 0.178024911982974 914 6710676 An epoxy ketone and protein crosslinker. SGTC_2193 5925765 200 µM 0.920814922079594 0.195320241509167 no 685 0.178573531461065 866 877370 SGTC_409 arachidonic acid 100 µM 0.91999359604993 0.195520334383114 no 686 0.178788052883728 876 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes. SGTC_1121 fusaric acid 630.51 nM 0.918696725547175 0.195836533573298 no 687 0.179127111509315 888 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler. SGTC_2408 sulbentine 18.36 µM 0.91852096334373 0.195879411268037 no 688 0.179173094535238 861 67686 An antifungal agent of unknown mechanism. YDL205C HEM3 SGTC_1025 k007-0731 70 µM 0.918197461392693 0.19595834538891 no 689 0.17925774874084 875 6256118 SGTC_1716 st033144 30.6155 µM 0.917543478315755 0.196117975469366 no 690 0.179428960275905 931 674617 SGTC_884 0851-0618 334 µM 0.916791310875613 0.196301668754665 no 691 0.179626003360258 914 9642473 SGTC_3221 9128209 49.47 µM 0.916196805409173 0.196446931827584 no 692 0.17978184037694 852 16460723 SGTC_3204 9114183 49.47 µM 0.916185021893835 0.196449811701832 no 693 0.179784930034062 837 17027248 SGTC_118 0083-0097 135.343 µM 0.916095478632781 0.196471696782334 no 694 0.179808409514337 1057 5207356 SGTC_1947 st076332 61.6 µM 0.915711220249956 0.196565629340217 no 695 0.17990918923901 864 24208416 SGTC_3238 9133470 49.47 µM 0.915055176369841 0.196726063153792 no 696 0.180081332310346 899 3534688 SGTC_800 3448-7362 155 µM 0.914617131719775 0.196833229968739 no 697 0.180196330883058 1074 15991913 SGTC_2325 6158266 200 µM 0.9108241209732 0.197762660513405 no 698 0.181194025536271 854 3623240 SGTC_2377 9073351 62.6 µM 0.91080772264586 0.197766684470121 no 699 0.181198346368301 854 7337946 YHR072W ERG7 SGTC_1454 4239-0054 42.6 µM 0.910449307028915 0.197854647805963 no 700 0.181292802222506 960 1340767 SGTC_2641 levomentholum 100 µM 0.909890117798582 0.197991932744978 no 701 0.181440230962969 872 16666 SGTC_3141 9094609 49.47 µM 0.9089523371478 0.198222293676579 no 702 0.181687642736988 814 25236309 YDL196W YDL196W SGTC_2661 dactinomycin 12.96 µM 0.908171575202644 0.198414207149045 no 703 0.18189378970346 939 45006140 An Actinomycin D Classic transcription inhibitor. SGTC_2110 5483698 200 µM 0.905644012630251 0.199036257622959 no 704 0.182562152579356 888 2848765 YHR062C RPP1 SGTC_477 mead ethanolamide 10 µM 0.904196561315793 0.199393013856962 no 705 0.182945591623786 783 16061185 SGTC_2744 captopril 92.04 µM 0.90406188568046 0.199426227196936 no 706 0.182981293592252 863 44093 angiotensin-converting enzyme (ACE) inhibitor  SGTC_3258 9138477 49.47 µM 0.903142638756253 0.199653018319687 no 707 0.183225098344774 908 4970355 SGTC_3143 9086658 49.47 µM 0.903132371724041 0.199655552216691 no 708 0.183227822533847 950 25236626 SGTC_1449 4112-4002 201 µM 0.89503640680738 0.201659649754349 no 709 0.185383813262982 855 2059539 SGTC_235 0330-0087 5 mM 0.89409417993281 0.201893671450452 no 710 0.185635751512635 954 46494818 YHR062C RPP1 SGTC_2394 5221648 200 µM 0.894030131273572 0.201909585170226 no 711 0.185652884933503 1009 788586 SGTC_777 1315-0167 517 µM 0.893545671565092 0.202029979785195 no 712 0.18578251274105 861 4221767 SGTC_2431 5490079 200 µM 0.888569468530927 0.203269117150716 no 713 0.187117252872685 943 5722345 SGTC_216 k038-0035 28.382 µM 0.887815868946407 0.203457167635165 no 714 0.187319902704944 884 4444231 YPR107C YTH1 SGTC_2130 NSC 7 2.4545 µM 0.886342200704125 0.203825201189461 no 715 0.187716577510263 963 21448 SGTC_1771 st048882 4.1505 µM 0.885703933218922 0.203984725031134 no 716 0.187888544145503 923 4580403 SGTC_14 0354-0009 295 µM 0.885328719860344 0.204078537785008 no 717 0.187989682224668 938 1713507 SGTC_2098 5376439 882.5 nM 0.885165135752955 0.204119445960136 no 718 0.188033786542219 971 2844116 SGTC_2513 baicalein 25.65 µM 0.88262007311532 0.204756529550547 no 719 0.1887207896943 923 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2 SGTC_2952 9073731 13.78 µM 0.880992101261374 0.205164665200706 no 720 0.189161047603391 975 16457353 SGTC_1943 st076331 65.2 µM 0.879779339640083 0.205469020812864 no 721 0.189489429521108 982 24208415 SGTC_3165 9101544 49.47 µM 0.87658285192921 0.206272497406002 no 722 0.190356628320773 946 5002184 SGTC_2244 6635614 200 µM 0.875962796824548 0.20642857128286 no 723 0.190525129506089 794 836499 SGTC_2330 7979373 200 µM 0.868674840539156 0.208268259014246 no 724 0.192512503246707 914 1863007 SGTC_867 0518-0118 155 µM 0.865922471940992 0.208965543831005 no 725 0.193266339397228 993 6848158 SGTC_3002 9075603 71.4286 µM 0.865148329614298 0.20916191247341 no 726 0.19347869058216 999 20105405 SGTC_2806 7952793 58.44 µM 0.863986524679054 0.209456819247226 no 727 0.193797646558492 940 2972490 SGTC_501 nsc-95397 161 µM 0.863236419761115 0.209647352034122 no 728 0.194003746697155 918 262093 SGTC_2167 5876490 200 µM 0.86209776177102 0.209936775196346 no 729 0.194316861480887 970 686534 SGTC_2992 9074591 71.4286 µM 0.861507424489683 0.210086919028604 no 730 0.19447931690405 924 17741321 SGTC_2286 7945697 125 µM 0.861213134387744 0.210161791057854 no 731 0.194560333718788 959 1245733 SGTC_1147 3809-1045 12.3 µM 0.859449292036917 0.210610868658788 no 732 0.195046342356685 930 325925 SGTC_456 gingerol 170 µM 0.858562252897089 0.210836923121977 no 733 0.195291035538606 1024 442793 A herb. SGTC_350 k064-0020 19.8 µM 0.85730184097609 0.211158373114147 no 734 0.195639045679096 1012 2790705 SGTC_2998 9066762 71.4286 µM 0.855880816864386 0.211521129147951 no 735 0.196031853382607 970 4945196 SGTC_2626 ethyl orsellinate 100 µM 0.855429863883634 0.211636323698151 no 736 0.19615660834497 939 75653 A natural product. SGTC_1738 st035555 74 µM 0.853921506050079 0.212021895799364 no 737 0.196574241316633 971 5331140 SGTC_3072 9116419 49.47 µM 0.853254619415852 0.212192498752244 no 738 0.196759059997148 934 17170162 SGTC_708 3448-5400 146 µM 0.85249892364202 0.212385917818506 no 739 0.196968618080036 970 3462195 SGTC_3026 9090633 49.47 µM 0.852190999669003 0.212464759974659 no 740 0.197054045609724 1002 25236842 SGTC_1279 0874-0590 65.2 µM 0.849815648487613 0.213073529381406 no 741 0.197713794071957 967 3523074 SGTC_438 sphingosine 6.67 µM 0.846152607223522 0.214014307614388 no 742 0.198733808240605 932 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes. SGTC_385 1494-0393 12.4 µM 0.846096714209986 0.214028681309495 no 743 0.198749396801774 987 3090647 SGTC_1594 piperine 70.1 µM 0.843908376694636 0.214591885404769 no 744 0.199360303453465 969 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_3030 9087619 49.47 µM 0.841348167248757 0.215251888993888 no 745 0.200076456956831 1008 25236973 SGTC_222 nsc-310342 10.666 µM 0.840171675697296 0.21555557469179 no 746 0.200406068511538 951 432556 SGTC_2871 9038510 12.99 µM 0.838303152009033 0.216038403771308 no 747 0.200930233045901 1042 4945164 SGTC_1733 st037357 54.9 µM 0.837829603899596 0.216160868681623 no 748 0.201063204882171 973 1272339 YGL099W LSG1 SGTC_2419 paclitaxel 166.5 µM 0.836300233907843 0.216556655568576 no 749 0.201493010802138 1016 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_976 1348-1067 47.6 µM 0.835546421404028 0.216751889461703 no 750 0.201705060617079 1080 5310671 YGL099W LSG1 SGTC_279 1273-0055 2.93 µM 0.834155199794043 0.217112476456417 no 751 0.202096766398602 1075 2847562 SGTC_2481 5478948 45.16 µM 0.830979868630715 0.217936779047194 no 752 0.202992501028999 957 77792 SGTC_2415 st077333 57.7 µM 0.830950915961401 0.217944303330908 no 753 0.203000679229423 1063 2766255 SGTC_294 k038-0071 157 µM 0.828713807481049 0.218526140809316 no 754 0.203633185403268 1009 24152826 SGTC_481 bay k-8644 50 µM 0.828537910229651 0.218571926872246 no 755 0.203682967284398 936 2303 A calcium channel antagonist. SGTC_1464 k208-0027 110 µM 0.828329538209273 0.218626173265297 no 756 0.20374194946002 1006 X1464 SGTC_2143 5623677 140.463 µM 0.8277778088984 0.218769844775888 no 757 0.203898172162123 990 5375313 SGTC_1416 3966-0321 25.3 µM 0.826434878874127 0.219119773649701 no 758 0.204278722355222 1031 582530 YLR208W SEC13 SGTC_3120 9124077 49.47 µM 0.825872470945317 0.219266416510078 no 759 0.204438219170305 1072 18774327 YGL155W CDC43 SGTC_2600 tangeritin 87.95 µM 0.825558687808624 0.219348257178261 no 760 0.204527239116245 955 68077 A bioactive flavone. SGTC_1811 st050069 61.5 µM 0.824082664906229 0.219733467715279 no 761 0.204946294622902 1024 3877702 SGTC_2032 5185112 25.99 µM 0.822668778390649 0.220102825915489 no 762 0.205348187362455 973 5718189 SGTC_2137 5261020 140 µM 0.822135865323025 0.220242134405728 no 763 0.205499787591519 983 763655 SGTC_946 3434-1334 87.4 µM 0.821698372256184 0.220356536990105 no 764 0.205624292911727 978 4047976 SGTC_3206 9114350 49.47 µM 0.819030091684421 0.221055018108572 no 765 0.20638462264334 921 17087243 SGTC_2009 4012297 12.05 µM 0.818361494914827 0.221230236325902 no 766 0.206575400787122 949 45595307 SGTC_3164 9100705 49.47 µM 0.816705546472468 0.2216645502992 no 767 0.207048360447761 996 17174235 SGTC_144 4161-2749 112.381 µM 0.813238199434829 0.222575525278681 no 768 0.208040751027907 926 797501 YMR168C CEP3 SGTC_675 1309-0189 238 µM 0.81296413277471 0.222647621636601 no 769 0.208119311295831 1000 4246530 SGTC_11 0438-0307 1.3 µM 0.808284349851563 0.223880744479867 no 770 0.209463454851315 1017 4011476 SGTC_3191 9110352 49.47 µM 0.808203088838902 0.223902190984467 no 771 0.209486839946564 1014 17122424 SGTC_753 1322-0200 289 µM 0.807348530388986 0.22412779776636 no 772 0.209732855677213 1056 5403907 SGTC_2295 7971645 200 µM 0.806297026700887 0.224405575952397 no 773 0.210035802247819 1001 2978226 YKL099C UTP11 SGTC_1783 st039459 87.517 µM 0.806211247335621 0.224428245104659 no 774 0.210060527302262 1083 729761 SGTC_1742 st038235 28.8875 µM 0.805438370973461 0.224632553897237 no 775 0.210283378380299 993 564103 YBR002C RER2 SGTC_274 sirtinol 40.1 µM 0.803695446246487 0.22509368064487 no 776 0.210786442343595 1057 6836442 NAD-dependent acetyltransferase inhibitor. SGTC_2378 9074213 121.43 µM 0.803517534114263 0.225140781124611 no 777 0.210837833163736 1057 657714 SGTC_1401 3807-4679 7.6 µM 0.798951673151986 0.226351456488375 no 778 0.212159217342899 1009 3291456 SGTC_2862 9027634 71.43 µM 0.798719855455732 0.226413022776679 no 779 0.212226435502796 985 5012562 SGTC_1545 lovastatin 49.4 µM 0.797700418326799 0.226683877731397 no 780 0.21252218052137 1077 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12 SGTC_1665 st014639 11.4 µM 0.797345784479338 0.226778143496214 no 781 0.212625118407377 1110 981133 YIL048W NEO1 SGTC_1839 st053978 48 µM 0.796667208635132 0.226958578412869 no 782 0.212822166542028 1069 3788398 SGTC_2013 4024628 200 µM 0.796336987742995 0.227046414204798 no 783 0.21291809622649 1019 5230760 SGTC_457 grayanotoxin iii 135 µM 0.796062596140859 0.227119414484618 no 784 0.212997826607258 1050 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity. SGTC_1995 st072814 61.1 µM 0.795532486444177 0.227260484533771 no 785 0.213151910707549 998 5769371 SGTC_3330 9141424 71.43 µM 0.794242419293771 0.227603996744364 no 786 0.213527159015163 1068 27261020 SGTC_2822 7994718 71.43 µM 0.79401536604723 0.227664485514338 no 787 0.213593242949944 965 1018011 SGTC_2457 5731572 11.68 µM 0.793996703979862 0.227669457638263 no 788 0.213598675081755 1081 2865357 SGTC_2753 fluvastatin 17.09 µM 0.79317093415699 0.227889528207902 no 789 0.213839119724467 1031 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5 SGTC_2118 5526350 200 µM 0.789661657433276 0.228826096737308 no 790 0.214862694674985 1053 743594 SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM 0.788843382080793 0.229044791252317 no 791 0.215101775238983 1094 16623 A steroid. SGTC_623 k072-0108 16.9 µM 0.788130010590646 0.229235544505963 no 792 0.21531033135204 1035 5382803 SGTC_1406 3909-7906 11.9 µM 0.78787288461482 0.229304321003091 no 793 0.215385531595478 1076 X1406 SGTC_1707 st032323 6.317 µM 0.786992713604852 0.229539838211702 no 794 0.215643065779834 1020 3132057 YMR211W DML1 SGTC_2772 vinpocetine 57.06 µM 0.786138183963998 0.229768623884389 no 795 0.215893268142848 1039 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor. SGTC_149 3970-0822 46.1 µM 0.785625662029941 0.22990590408971 no 796 0.216043412884385 1145 3114250 YBL034C STU1 SGTC_521 r062-0005 13.8 µM 0.784171191707542 0.230295737308394 no 797 0.216469833293909 1010 2832033 SGTC_1637 st007924 17.4 µM 0.781574269749866 0.230992693527516 no 798 0.217232406614504 1038 683336 SGTC_2715 st079500 56.4 µM 0.781442272040598 0.231028150200159 no 799 0.217271208484691 1008 28246688 SGTC_3347 9188721 44.724 µM 0.780796744811464 0.231201592773727 no 800 0.217461024451916 1013 44118411 YKL104C | YBL026W GFA1 | LSM2 SGTC_1380 2291-0730 164 µM 0.78056614976307 0.231263567485714 no 801 0.217528853655922 1036 2999191 SGTC_2713 st079149 53.4 µM 0.778919846225884 0.231706297087516 no 802 0.218013466166469 1060 3103253 SGTC_249 wiskostatin 11.211 µM 0.777997796377622 0.231954464076635 no 803 0.218285156156039 1095 2775510 A n-wasp and actin depolymerizer. SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM 0.777489164512379 0.232091424156898 no 804 0.218435112394169 1151 6708784 An antioxidant flavonoid SGTC_1057 3448-5381 134 µM 0.77730502430341 0.232141018969228 no 805 0.218489415738652 1092 5497911 SGTC_1037 k284-1091 78.7 µM 0.776907909430768 0.232247994703823 no 806 0.218606552227279 1036 3334711 SGTC_2710 st078562 53.7235 µM 0.774508418279821 0.232894958523822 no 807 0.219315095948604 1089 17250908 SGTC_91 0417-1751 58.384 µM 0.774124659051845 0.232998522552566 no 808 0.219428538182939 1221 6795624 SGTC_3046 9092212 49.47 µM 0.774113242268166 0.233001603959736 no 809 0.219431913589964 1074 25236637 SGTC_1838 st055369 84.5 µM 0.773102304395829 0.233274547329957 no 810 0.219730918717339 1089 676036 SGTC_2890 9046729 58.44 µM 0.771993943193959 0.233573997854883 no 811 0.220059007402367 1006 903329 SGTC_2603 homopterocarpin 100 µM 0.769869483626634 0.234148567290294 no 812 0.220688658759541 1074 101795 A weak amylase inhibitor. SGTC_2210 7115885 190.385 µM 0.769794262961123 0.234168925385688 no 813 0.220710971702473 1092 2927039 SGTC_1355 1499-0035 1.68 µM 0.769345584177812 0.234290378400693 no 814 0.220844091540032 1067 1548538 SGTC_2303 7774051 200 µM 0.769026177179248 0.234376860032798 no 815 0.22093888535391 1062 2953184 SGTC_1642 st009582 77.7 µM 0.768822574518806 0.234431996065355 no 816 0.220999322835572 1074 6739311 SGTC_138 0850-0259 40.9225 µM 0.768560403782376 0.234503003026264 no 817 0.221077159619467 1125 6813004 SGTC_48 0382-0018 55 µM 0.767778841657688 0.234714753803269 no 818 0.221309293392315 1158 762596 SGTC_2732 terfenadine 20 µM 0.766884874288094 0.23495708840652 no 819 0.221574983770264 1086 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.  SGTC_975 1335-0046 28.5 µM 0.765829633001173 0.235243318593541 no 820 0.221888839824652 1101 16486740 SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM 0.764636663302847 0.235567138817582 no 821 0.222243965442125 1107 6312947 SGTC_3216 9129716 49.47 µM 0.762377276584038 0.236181101094047 no 822 0.22291743219073 1057 8056934 SGTC_3179 9107801 49.47 µM 0.760246146531762 0.236761017922927 no 823 0.223553732912876 1115 4818259 SGTC_2759 disulfiram 3.38 µM 0.758801986516409 0.237154443198584 no 824 0.223985508575328 1084 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_1904 st060225 78 µM 0.757402839873232 0.2375359480044 no 825 0.224404277630432 1105 66595 SGTC_1591 genipin 88.4 µM 0.755543783339001 0.23804337695959 no 826 0.224961386048801 1050 442424 A DNA cross-linking agent. SGTC_148 3253-0744 288.01 µM 0.754452422472389 0.23834154015051 no 827 0.22528880189888 1120 6893655 SGTC_2041 5107442 45.335 µM 0.752409456149759 0.238900234317002 no 828 0.225902430838048 1128 793005 SGTC_903 1134-0042 114 µM 0.751645071945014 0.239109455992851 no 829 0.226132265341988 1127 701009 SGTC_423 5-fluorouracil 457 µM 0.750512264449319 0.239419703906507 no 830 0.226473120012568 1082 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_1139 k015-0024 46.9 µM 0.740899666057939 0.242061183357146 no 831 0.229377138998801 1131 2766652 SGTC_1633 st005664 67.9 µM 0.740179562715219 0.242259697377312 no 832 0.229595523380744 1158 2063822 SGTC_942 3253-1115 227 µM 0.73858210388314 0.242700390610704 no 833 0.230080397265636 1145 46497897 SGTC_1383 3049-0032 20.7 µM 0.737902136041093 0.242888105898508 no 834 0.230286960430786 1160 712864 SGTC_2920 7982904 15.77 µM 0.737825242842003 0.242909338358596 no 835 0.230310325858666 1079 6456808 SGTC_2259 7964009 200 µM 0.737243170990872 0.243070097980921 no 836 0.230487242205276 1117 313134 SGTC_1278 0874-0585 172 µM 0.733477164270528 0.244111602298871 no 837 0.231633725350395 1150 766306 SGTC_2029 5175081 200 µM 0.732978146020496 0.244249788155068 no 838 0.23178587928456 1169 1380876 SGTC_153 4077-0274 519.67 µM 0.732150151370686 0.244479165656958 no 839 0.232038463073325 1163 3121976 SGTC_1583 clindamycin 39.6 µM 0.731756619113374 0.244588225689489 no 840 0.232158565703004 1078 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis. SGTC_540 1187-0821 17.3 µM 0.731650364424664 0.244617676661571 no 841 0.232190999642911 1117 847520 SGTC_399 oxolinic acid 75 µM 0.731337457637212 0.244704417188229 no 842 0.232286528191076 1107 4628 A DNA gyrase inhibitor. SGTC_2202 7226349 200 µM 0.731174779850357 0.244749519450493 no 843 0.23233620137295 1114 844334 SGTC_3300 9124615 50.48 µM 0.731113501925 0.244766509857559 no 844 0.232354913938618 1138 24824903 SGTC_1803 st050068 52.4 µM 0.731034471114931 0.244788423508735 no 845 0.232379048976945 1219 3984059 YIL048W | YNL267W NEO1 | PIK1 SGTC_791 1348-1292 225 µM 0.730503333974608 0.244935724530657 no 846 0.23254128790655 1166 5437054 SGTC_1939 st074455 53.6 µM 0.729447786438355 0.245228602559545 no 847 0.232863897914776 1145 1644229 SGTC_600 1495-0418 41.6 µM 0.727095362341656 0.245881995937496 no 848 0.233583769772987 1154 5377768 SGTC_1231 0242-0792 125 µM 0.726894761784087 0.245937756591813 no 849 0.23364521315978 1149 3707635 SGTC_146 3448-8650 53.125 µM 0.726358105534677 0.246086963526313 no 850 0.233809633505465 1168 2891488 YIL048W NEO1 SGTC_2321 7390090 138.78 µM 0.725504318081673 0.246324442722851 no 851 0.234071348386018 1102 649046 SGTC_3201 9113999 49.47 µM 0.72319836527533 0.246966452161249 no 852 0.234779011507553 1117 16649224 SGTC_2058 5236698 133 µM 0.722059902857612 0.247283745828706 no 853 0.235128824562443 1132 766665 SGTC_1003 4049-0218 100 µM 0.720995900118786 0.247580484224242 no 854 0.235456018616332 1168 295161 SGTC_3198 9112019 49.47 µM 0.72022044571695 0.247796869511675 no 855 0.235694638673445 1183 45595555 SGTC_3005 9076496 71.4286 µM 0.719509734521931 0.247995277287471 no 856 0.235913453259999 1147 21368410 SGTC_2900 5328528 85.29 µM 0.717259038581976 0.248624158294017 no 857 0.236607138321235 1208 795359 SGTC_3112 9123419 49.47 µM 0.717246135887981 0.248627765963553 no 858 0.23661111828198 1222 17015854 SGTC_2017 5132927 60.65 µM 0.716815757213965 0.248748118361169 no 859 0.236743893848397 1169 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis SGTC_963 1269-2853 151 µM 0.716583745441115 0.248813011704007 no 860 0.236815488495809 1156 3668223 SGTC_2319 6033012 152.6 µM 0.716288447419644 0.248895619149298 no 861 0.236906629355055 1113 847246 SGTC_2589 lobaric acid 100 µM 0.714486552728705 0.249400002056204 no 862 0.237463184222405 1173 73157 A novel microtubule depolymerizer. SGTC_292 k038-0015 474 µM 0.714472172305023 0.249404029580855 no 863 0.237467628818076 1168 46368540 SGTC_1348 1493-0373 93.8 µM 0.713667829157507 0.249629356964045 no 864 0.237716301984376 1157 3010129 SGTC_2328 6201408 200 µM 0.713593250696509 0.249650254729569 no 865 0.237739366122104 1120 2890418 SGTC_2222 6885208 172.143 µM 0.713311528810035 0.249729204913432 no 866 0.237826502519322 1119 609514 SGTC_2784 7567673 72.73 µM 0.712314045895719 0.250008847636388 no 867 0.238135164088595 1214 3471247 SGTC_2307 7538926 6.34 µM 0.712008180770631 0.25009462970451 no 868 0.23822985509026 1180 96582 SGTC_2908 7930301 100 µM 0.711056700871431 0.25036157886973 no 869 0.238524550054584 1147 2223178 SGTC_1617 st002906 78 µM 0.708199431801431 0.251164127157414 no 870 0.239410709485189 1171 5150859 SGTC_3036 9090181 49.47 µM 0.708003095124555 0.251219324022021 no 871 0.239471667703947 1173 25236586 SGTC_1928 4'-methoxychalcone 40.3 µM 0.70715284499266 0.251458432044774 no 872 0.239735749460445 1203 641818 SGTC_1374 2889-5571 141 µM 0.705150614309581 0.252021975698201 no 873 0.240358255561982 1173 2853281 SGTC_2795 7780010 54.55 µM 0.703315861075423 0.252538966006904 no 874 0.240929464148714 1159 953673 SGTC_2263 7948595 193.29 µM 0.702006195783088 0.25290834037245 no 875 0.241337649780864 1152 2971371 SGTC_574 1315-0397 40 µM 0.701844902464761 0.252953850750512 no 876 0.24138794632091 1234 6794277 SGTC_1866 st057638 64 µM 0.701220958873481 0.253129942688502 no 877 0.24158256598197 1165 688802 SGTC_1702 st027038 51 µM 0.701118028634488 0.253158998280281 no 878 0.241614680031182 1201 5521182 SGTC_1369 1866-0067 208 µM 0.70051634167338 0.253328880160788 no 879 0.241802451645619 1214 3531355 SGTC_1991 st073000 8.92 µM 0.698818980242806 0.253808440449574 no 880 0.242332582680838 1228 4301969 YIL048W NEO1 SGTC_1914 st062367 72.6 µM 0.698590426790888 0.253873050685593 no 881 0.242404014073263 1181 978205 SGTC_1490 4089-0339 670 nM 0.698185944197644 0.253987415839909 no 882 0.242530457771679 1154 742542 SGTC_1052 3253-3998 198 µM 0.695633642173719 0.254709687726408 no 883 0.243329146012305 1192 5450317 SGTC_90 0870-0863 4.608 µM 0.695331001128575 0.254795402903453 no 884 0.243423945221623 1198 1738164 SGTC_1878 temozolomide 1 mM 0.693965886387244 0.255182223618038 no 885 0.243851801337018 1169 5394 DNA alkylating agent. SGTC_2119 5528445 120.635 µM 0.691000410630295 0.256023581678955 no 886 0.244782641497613 1193 791935 SGTC_2168 5727979 200 µM 0.689579872048989 0.256427125695308 no 887 0.245229214347415 1151 695210 SGTC_908 3448-7491 47.7 µM 0.687823756195282 0.256926457625345 no 888 0.245781887096635 1236 1203031 SGTC_454 lyso-paf C-16 6.67 µM 0.687472901720029 0.257026279777868 no 889 0.245892385700813 1155 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_2534 helenine 20.12 µM 0.686702670169008 0.257245490289082 no 890 0.24613505699437 1215 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58 SGTC_95 0471-0001 561.058 µM 0.685600108472881 0.257559452135798 no 891 0.246482656559185 1150 4015405 SGTC_199 4063-0024 41.6 µM 0.683986783745888 0.258019215578876 no 892 0.246991755690099 1233 306215 SGTC_1848 st056003 16.4 µM 0.683778754418755 0.258078530507652 no 893 0.247057442143171 1269 146492 SGTC_1128 3448-9350 235 µM 0.682061152698635 0.258568536455938 no 894 0.247600141674647 1205 619386 SGTC_1670 st016595 4.04 µM 0.682015683200126 0.258581514762984 no 895 0.247614517025646 1218 597879 SGTC_3149 9097855 49.47 µM 0.681957930561192 0.258597999519078 no 896 0.247632776379862 1214 25236625 YMR079W SEC14 SGTC_2256 7954252 200 µM 0.681921229861534 0.258608475549686 no 897 0.24764438022465 1169 2972920 SGTC_2945 9067681 61.76 µM 0.681617609067866 0.258695151010007 no 898 0.24774038867649 1292 16456930 SGTC_436 n,n-dimethylsphingosine 3.3 µM 0.681430508160209 0.258748570706742 no 899 0.247799562071321 1318 5282309 SGTC_446 go6976 132 µM 0.68034860642493 0.259057579378268 no 900 0.248141877214356 1188 3501 A protein kinase C inhibitor. SGTC_936 3005-4620 401 µM 0.680309767998796 0.259068675809382 no 901 0.248154170431838 1237 777207 SGTC_2086 5274770 176.623 µM 0.680096907940858 0.259129495896925 no 902 0.248221551097698 1222 689278 SGTC_1018 4259-0013 28.1 µM 0.677149280744318 0.259972473890871 no 903 0.249155622053293 1218 6801262 SGTC_1933 st074711 15.9 µM 0.674533863929404 0.260721627013723 no 904 0.249985981897571 1226 17250958 SGTC_3245 9134821 49.47 µM 0.67441566503288 0.260755509813365 no 905 0.250023543117444 1201 17014901 SGTC_3222 9128301 49.47 µM 0.674282836725179 0.260793588971636 no 906 0.250065756841595 1252 4911358 SGTC_277 nystatin 15.5 µM 0.673843198353476 0.260919644700563 no 907 0.25020550382038 1219 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_2161 5662504 8.5105 µM 0.673658271201485 0.260972677474585 no 908 0.250264298620297 1203 2859334 SGTC_1211 1056-0033 32.3 µM 0.67309813690909 0.261133344678244 no 909 0.25044242956418 1234 6741922 SGTC_2233 sulbentine 40.3845 µM 0.672226863416661 0.26138335909928 no 910 0.250719640843222 1226 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58 SGTC_2852 9023854 51.95 µM 0.66901066358307 0.262307320161534 no 911 0.251744337837294 1298 19798528 SGTC_793 0488-0545 106 µM 0.667093764097054 0.262858808272828 no 912 0.252356121550665 1221 292548 SGTC_3050 9093513 49.47 µM 0.665191075942624 0.263406793536712 no 913 0.252964143817499 1245 25236664 SGTC_1789 tunicamycin 25 nM 0.663381902851551 0.263928386301187 no 914 0.253542996658534 1240 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_24 0417-1663 219 µM 0.661213952576208 0.264554108829702 no 915 0.254237557324862 1230 4329390 SGTC_825 1988-2224 89.6 µM 0.659569406928184 0.265029267113267 no 916 0.254765096032016 1263 1180859 SGTC_2060 5238662 140 µM 0.658694475339528 0.265282237521436 no 917 0.255045990682507 1224 790130 SGTC_1520 flindersine 88 µM 0.657404263411397 0.265655502144595 no 918 0.255460505495286 1341 68230 Flindersine is a natural alkaloid of the quinoline subtype. SGTC_1985 st071382 65.5 µM 0.655538886803806 0.266195635192973 no 919 0.256060429006565 1287 6123237 SGTC_2266 7929956 200 µM 0.65465571029486 0.266451559016238 no 920 0.256344723397896 1268 2967153 SGTC_420 mitomycin C 81.9 mM 0.654443932428934 0.266512945767619 no 921 0.256412919107546 1259 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_3174 9107204 49.47 µM 0.653494271663007 0.266788306037294 no 922 0.256718840592649 1278 3938802 SGTC_1274 0865-0114 173 µM 0.653462356293147 0.266797562601309 no 923 0.256729125034166 1279 870624 SGTC_2141 5621638 7.665 µM 0.65154922644096 0.267352732891391 no 924 0.257346005531232 1286 2856238 SGTC_1757 st041620 31.8375 µM 0.651502219805163 0.267366381058102 no 925 0.257361172308986 1265 5289815 SGTC_2274 7947094 46.08 µM 0.64880895267403 0.268148945648566 no 926 0.258230935022774 1271 2971028 SGTC_2805 7950783 58.44 µM 0.647336081818265 0.268577394908142 no 927 0.258707227045332 1268 1178958 YDL195W SEC31 SGTC_1062 mesoridazine 14.2 µM 0.646993913531428 0.268676978830154 no 928 0.258817941330976 1273 4078 A neuroleptic. SGTC_1063 disulfiram 1.84 µM 0.646817555505782 0.268728312934892 no 929 0.258875014500288 1274 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_2528 xanthyletin 44.79 µM 0.645853448528548 0.269009031225463 no 930 0.259187134870182 1320 65188 An natural product with antifungal activity of unknown mechanism. SGTC_1436 4092-1007 8.32 µM 0.645819470088078 0.269018927386481 no 931 0.259198138611341 1243 2881121 SGTC_237 nikkomycin 200 µM 0.643367878805138 0.269733430898665 no 932 0.259992710459491 1322 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine. SGTC_67 0335-0847 266 µM 0.640718844785009 0.270506544899794 no 933 0.260852684142426 1382 4552207 YOR254C SEC63 SGTC_2114 5491910 81.25 µM 0.64045308291709 0.270584167905333 no 934 0.260939040890628 1333 2849228 SGTC_270 tamoxifen 5.46 µM 0.640212571409866 0.270654425443484 no 935 0.261017205449705 1370 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  YIL048W NEO1 SGTC_2762 leflunomide 42.06 µM 0.63908115332894 0.270985054262656 no 936 0.261385069869132 1295 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1 SGTC_2012 4023501 200 µM 0.63836564318062 0.271194248279843 no 937 0.261617845131024 1254 3477460 SGTC_2406 ethylparaben 405.7 µM 0.637685517195491 0.271393171626526 no 938 0.261839207533381 1186 8434 A possible steroid mimic. SGTC_2184 6075246 200 µM 0.636618114221636 0.271705512317191 no 939 0.262186811592345 1305 2267320 SGTC_1798 st045719 60.953 µM 0.635146934293849 0.272136298234021 no 940 0.262666294453497 1228 3980186 SGTC_504 lovastatin 124 µM 0.634255783175762 0.272397407102142 no 941 0.2629569539764 1241 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1 SGTC_1775 st081588 35.1725 µM 0.633830989410971 0.27252191621474 no 942 0.263095563354327 1305 1426443 YGL099W LSG1 SGTC_1157 4092-0394 27.6 µM 0.632230536069022 0.272991270483162 no 943 0.263618123263705 1389 3659885 SGTC_1229 0139-0193 12.2 µM 0.631489237069785 0.273208802013255 no 944 0.263860342208227 1334 3090752 SGTC_2331 7980721 200 µM 0.631441567169691 0.273222793512596 no 945 0.263875922197674 1284 2981221 SGTC_196 k015-0023 18.111 µM 0.629505521334775 0.27379133833796 no 946 0.264509077585434 1296 5211998 SGTC_995 3931-2021 34.6 µM 0.628661339314349 0.274039426319004 no 947 0.264785396753341 1301 730143 SGTC_2465 5809242 33.21 µM 0.628625331533421 0.274050010745433 no 948 0.264797186147145 1295 2731748 SGTC_1505 k297-0037 20.6 µM 0.628321567110529 0.274139309824228 no 949 0.264896653005072 1285 4089396 SGTC_1699 st031318 29.054 µM 0.627272660061863 0.274447772509491 no 950 0.265240260782889 1351 5340658 SGTC_829 1635-0120 117 µM 0.626887910027826 0.274560962759914 no 951 0.265366356399643 1315 285054 SGTC_1134 3477-0009 42.5 µM 0.625696916985549 0.2749114888954 no 952 0.265756877914993 1414 3973534 SGTC_400 oxethazaine 37.5 µM 0.623420243137999 0.275582159370787 no 953 0.266504199386862 1284 4621 A local anesthetic. SGTC_2785 7756463 72.73 µM 0.62273266432724 0.275784866791218 no 954 0.266730106921763 1281 2201551 SGTC_2162 5663267 200 µM 0.620766089338974 0.276365043547285 no 955 0.267376769051927 1306 6456493 SGTC_2174 5790901 200 µM 0.620672717616003 0.276392604849301 no 956 0.267407491811224 1310 786020 SGTC_609 0986-0026 86.3 µM 0.619993172661874 0.276593232340662 no 957 0.267631140923945 1337 2848610 SGTC_2343 7990716 14.84 µM 0.61936299509614 0.276779348472853 no 958 0.26783862666569 1305 6456862 SGTC_1831 st055328 12 µM 0.616928629886582 0.277498887627826 no 959 0.268640900909078 1331 1103068 SGTC_1472 k841-0093 193 µM 0.616453309074059 0.27763948750729 no 960 0.268797689376544 1367 X1472 SGTC_2204 7233102 200 µM 0.615464229293658 0.277932168775731 no 961 0.269124092709711 1270 2172480 SGTC_769 0302-0231 76 µM 0.61540611931027 0.27794936894015 no 962 0.269143275599407 1325 571869 YER009W NTF2 SGTC_2474 5321570 43.32 µM 0.614641084076895 0.278175862652981 no 963 0.269395888006378 1370 2841384 SGTC_136 0097-0015 404.482 µM 0.614549267168947 0.278203051700728 no 964 0.269426213669287 1310 4861337 SGTC_864 0469-0573 172 µM 0.61428663420099 0.278280830372621 no 965 0.269512966604566 1275 689425 SGTC_2726 cimetidine 79.27 µM 0.61368169967651 0.27846002186373 no 966 0.26971284185155 1309 2756 A P450 inhibitor, histamine H2-receptor antagonist. SGTC_2926 9010726 65.15 µM 0.609904912515937 0.279580037366162 no 967 0.27096239906699 1293 2994293 SGTC_401 neomycin 50 µM 0.609184515278123 0.279793921033315 no 968 0.271201071455722 1316 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis. SGTC_73 0327-0325 16.231 µM 0.606611872967581 0.280558377662949 no 969 0.272054259498416 1345 53298 SGTC_1107 amlodipine 47 µM 0.606094974023361 0.28071209522769 no 970 0.272225844128084 1233 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.  SGTC_1900 st060200 72.8 µM 0.603887504939823 0.281369019660406 no 971 0.27295921831997 1335 688945 SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM 0.602811951403505 0.281689364051223 no 972 0.273316897598357 1358 368090 SGTC_317 4495-0002 170 µM 0.602301668494998 0.281841408915096 no 973 0.273486675207608 1293 15991618 SGTC_2300 7976697 71.57 µM 0.601670098810874 0.282029647363688 no 974 0.273696878734454 1281 2236109 SGTC_2208 7283366 200 µM 0.599928194387917 0.282549133059195 no 975 0.274277045662068 1368 898663 SGTC_3095 9117207 49.47 µM 0.596843736263872 0.283470133562095 no 976 0.275305857235512 1318 17015229 SGTC_3256 9138902 49.47 µM 0.59394293281101 0.284337606700563 no 977 0.276275141240142 1379 17228773 SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM 0.593773754485341 0.284388237899632 no 978 0.276331722675825 1331 6857784 SGTC_2962 9082311 13.18 µM 0.593138103392977 0.284578512208981 no 979 0.276544366015793 1315 16459453 SGTC_2359 9039622 200 µM 0.592938031100233 0.284638413956739 no 980 0.276611312473155 1319 6463596 SGTC_1549 4'-methoxyflavonol 74.6 µM 0.592096689673004 0.284890377877416 no 981 0.276892921756945 1340 97141 SGTC_475 α-linolenic acid 10 µM 0.59104959093015 0.285204110283554 no 982 0.277243597000673 1422 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_1020 4335-0961 93.3 µM 0.590448970320515 0.285384142894321 no 983 0.277444843912409 1295 669075 SGTC_2622 2-methoxyxanthone 59.94 µM 0.585937569085199 0.286738136817726 no 984 0.278958734751391 1420 71034 A hepatoprotective. SGTC_3181 9108277 49.47 µM 0.584960918231148 0.287031656760609 no 985 0.279286997796917 1307 17097298 SGTC_563 tetrahydrosecaminediol 614 µM 0.582380272393364 0.28780792092814 no 986 0.280155283293101 1420 334274 A psychoactive constituent of the cannabis plant. SGTC_1729 st035615 45.989 µM 0.582074399035465 0.287899994028117 no 987 0.280258284250385 1354 17385451 SGTC_1573 oleylamine 1.06 µM 0.579595867378526 0.28864658685629 no 988 0.281093590280804 1366 5356789 An amine of the fatty acid oleic acid. SGTC_480 am 92016 50 µM 0.579277613388185 0.288742518572396 no 989 0.281200934188581 1295 2129 K+ channel blocker. SGTC_2353 9059630 146.67 µM 0.574119537414852 0.290299413458671 no 990 0.282943456625852 1408 4779114 SGTC_2874 9043904 71.43 µM 0.572347121028201 0.290835299318592 no 991 0.283543416177359 1355 4463428 SGTC_2242 6630449 61.2675 µM 0.572160445743193 0.290891767052144 no 992 0.283606640870126 1394 691249 YDR170C SEC7 SGTC_1303 1160-0052 261 µM 0.571974937493787 0.290947886842805 no 993 0.283669476991937 1392 3562476 SGTC_2961 9083290 32.55 µM 0.571859905302666 0.290982688820087 no 994 0.283708444520952 1405 17741490 SGTC_125 0133-0007 11.75 µM 0.570758901663351 0.291315886141604 no 995 0.284081542721671 1451 26541 SGTC_1371 2421-0008 32.7 µM 0.569802554638732 0.291605450380451 no 996 0.284405811336451 1400 2827552 SGTC_2417 cerulenin 830 nM 0.568885630370045 0.291883204078666 no 997 0.284716878851306 1444 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1 SGTC_1963 st076565 50.3 µM 0.567565196350464 0.292283404866797 no 998 0.285165122579962 1401 4914280 SGTC_3265 9137266 49.47 µM 0.564558353603937 0.293195678077813 no 999 0.286187099441431 1375 17224265 SGTC_1748 st037455 53.6035 µM 0.564134811301289 0.29332428640998 no 1000 0.286331194228481 1409 580690 SGTC_1478 0453-0656 35.7 µM 0.563526195702131 0.29350913788431 no 1001 0.286538313725353 1400 5258496 SGTC_2807 7945238 51.95 µM 0.561151103207691 0.294231027251806 no 1002 0.28734726653891 1431 17148797 SGTC_1261 0712-0010 12.7 µM 0.558570876132781 0.295016193763489 no 1003 0.288227310445466 1456 2840123 SGTC_760 0568-0725 82.9 µM 0.553561520301746 0.296543296818297 no 1004 0.289939483346676 1430 3916171 SGTC_2930 9013230 14.89 µM 0.553123600291993 0.296676968787871 no 1005 0.290089388642615 1459 2995857 SGTC_1069 diphenylcyclopropenone 8.49 µM 0.552476728568434 0.296874472250156 no 1006 0.290310887062377 1455 65057 A dermal irritant. YDR527W RBA50 SGTC_1936 st074407 74.3 µM 0.548609727888462 0.298056401327591 no 1007 0.291636654245444 1411 809813 SGTC_351 caspofungin 25 nM 0.547736057307911 0.298323730953236 no 1008 0.291936574937214 1500 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1 SGTC_1257 0669-0121 16 µM 0.54479621015735 0.299224079062284 no 1009 0.292946842753259 1485 4307855 SGTC_3291 9121177 71.43 µM 0.544703108925059 0.29925261207702 no 1010 0.292978863140178 1382 17015612 SGTC_2720 fluspirilene 36.88 µM 0.54451678256058 0.299309719785587 no 1011 0.293042951403851 1427 3396 An atypical antipsychotic. SGTC_1526 st051518 75 µM 0.544369814492831 0.299354767942626 no 1012 0.293093506691912 1420 673993 SGTC_1613 st002381 52.1 µM 0.544230146354645 0.299397581399313 no 1013 0.293141554638471 1399 551167 SGTC_2712 st079126 47.7 µM 0.542160789279353 0.300032241032658 no 1014 0.293853872274007 1370 3152970 SGTC_2728 chlorpromazine 9.18 µM 0.540752483384725 0.300464507910888 no 1015 0.294339099132817 1428 2726 A thorazine and dopamine antagonist. SGTC_780 0109-0199 192 µM 0.53928022101442 0.300916706174571 no 1016 0.294846757185657 1543 610414 SGTC_2978 9011784 42.97 µM 0.538806170021943 0.301062373933643 no 1017 0.295010302903618 1544 2994934 SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM 0.538114133358262 0.301275082002656 no 1018 0.29524912782132 1539 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis. SGTC_583 1488-1091 88.9 µM 0.537476212891492 0.301471216556674 no 1019 0.295469355793269 1498 4303273 SGTC_1715 st032160 10.2275 µM 0.535907842242576 0.301953670758719 no 1020 0.2960111221237 1444 5289825 SGTC_664 1222-0054 14.9 µM 0.534420803923926 0.302411425980353 no 1021 0.296525214356151 1406 6813991 SGTC_3060 1327-0027 12.5 µM 0.531548324017505 0.30329654184475 no 1022 0.297519431823235 1406 16000455 YPR107C YTH1 SGTC_2656 pseudo-anisatin 100 µM 0.531184267011522 0.303408803725372 no 1023 0.297645547159828 1441 6708809 A neurotoxin. SGTC_2843 9000894 45.46 µM 0.530885553926277 0.303500929791849 no 1024 0.297749044504563 1331 2242070 SGTC_1997 st073024 93.8 µM 0.530453882164421 0.303634083696107 no 1025 0.297898638028485 1413 686268 SGTC_72 0744-0168 198.391 µM 0.528147371201652 0.304345993876311 no 1026 0.298698527043252 1480 677577 SGTC_66 0109-0187 42.4 µM 0.527542728572798 0.304532741158362 no 1027 0.298908376173441 1405 759417 SGTC_813 k007-0158 173 µM 0.526937340683748 0.304719769678021 no 1028 0.299118551026992 1524 6523916 SGTC_2272 7805186 180 µM 0.526331267570967 0.304907061029207 no 1029 0.29932903094297 1433 2956062 YPR165W RHO1 SGTC_2178 5812956 200 µM 0.526180374110517 0.304953698733869 no 1030 0.299381444375239 1453 5403383 SGTC_808 0711-0032 135 µM 0.525312197140084 0.3052220938475 no 1031 0.299683089861873 1493 4252555 SGTC_1955 wogonin 32.4 µM 0.525015596274718 0.305313811408935 no 1032 0.299786174486813 1521 5281703 A flavanone. SGTC_3318 9139014 38.6185 µM 0.524120798993347 0.305590582642727 no 1033 0.300097261524505 1446 16643984 SGTC_2698 st077697 67.5 µM 0.523863392042982 0.305670222202231 no 1034 0.300186779182666 1391 3154499 SGTC_2697 mebhydrolin 72.4 µM 0.52000042572631 0.306866494218462 no 1035 0.301531639184551 1558 22530 H1 Histamine receptor antagonist. YIL048W NEO1 SGTC_194 1486-1323 56.904 µM 0.519982054177908 0.306872188395755 no 1036 0.301538041560781 1415 5178754 SGTC_143 4032-1194 15.74 µM 0.519040338946399 0.307164131103212 no 1037 0.301866305646889 1455 1806963 SGTC_639 0833-0042 114 µM 0.518365818893699 0.307373315356495 no 1038 0.302101529215064 1421 5978911 YPR085C | YHR062C ASA1 | RPP1 SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM 0.515788242291486 0.3081732583358 no 1039 0.303001157688881 1489 279621 SGTC_2297 7971671 152.32 µM 0.515731883199751 0.308190759408644 no 1040 0.303020841584439 1540 909016 SGTC_2690 usnic acid 100 µM 0.515678579807097 0.308207312002784 no 1041 0.303039458777371 1599 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_2264 7948757 110.76 µM 0.515501495148857 0.308262305870697 no 1042 0.303101312534069 1435 2971411 SGTC_208 k072-0098 12.366 µM 0.510357858775922 0.3098615426831 no 1043 0.304900387315757 1459 5948901 SGTC_2769 toremifene 3.73 µM 0.510284431625019 0.309884398497345 no 1044 0.304926104036722 1481 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_1971 st069429 63.5 µM 0.509773432915405 0.31004347842238 no 1045 0.305105100091966 1480 1246522 YGL099W LSG1 SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM 0.50944411236983 0.310146018639667 no 1046 0.30522048141459 1575 551469 SGTC_1723 st034307 2.5525 µM 0.509115979199921 0.310248203830061 no 1047 0.305335465980832 1475 867466 SGTC_2645 abamectin 100 µM 0.508201732563582 0.310532990093207 no 1048 0.3056559379789 1489 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels. SGTC_3115 9123671 49.47 µM 0.507445071762371 0.310768774563304 no 1049 0.305921283867599 1535 3286988 SGTC_3229 9132204 49.47 µM 0.507013817842375 0.310903193177508 no 1050 0.306072561634723 1516 17682924 SGTC_3261 9137475 49.47 µM 0.506877839020891 0.310945581990811 no 1051 0.306120267940177 1450 17027690 SGTC_1749 st037932 54.2 µM 0.505261646058496 0.311449591402734 no 1052 0.306687538707234 1457 594497 SGTC_1334 1486-0610 236 µM 0.504910987509313 0.311558990902509 no 1053 0.3068106782646 1495 3742339 SGTC_2258 7960471 200 µM 0.504217641891265 0.311775351900488 no 1054 0.307054222229503 1432 2974708 SGTC_312 4092-0653 6.84 µM 0.502095808795857 0.312437881042176 no 1055 0.307800064126385 1524 1148278 SGTC_2381 9035592 200 µM 0.50051903994914 0.312930610407064 no 1056 0.308354826474659 1405 4749657 SGTC_881 0833-0569 170 µM 0.4991586410888 0.313355994380135 no 1057 0.308833814305189 1430 5418700 SGTC_2606 farnesol 9.78 µM 0.498855206138506 0.313450909549329 no 1058 0.308940696234917 1552 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_1651 st011928 86.1 µM 0.496963683387473 0.314042860691049 no 1059 0.309607330734525 1476 720198 SGTC_2313 7726885 200 µM 0.496460792511744 0.314200320780107 no 1060 0.30978467150435 1488 726423 SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM 0.496305360170546 0.314248995021534 no 1061 0.309839492536512 1537 6708739 YPR165W RHO1 SGTC_302 1094-0063 18.9 µM 0.494750802654069 0.314735988353481 no 1062 0.310388017932747 1437 5440289 SGTC_579 4491-1009 110 µM 0.492260982328758 0.315516641190482 no 1063 0.311267429549733 1608 1271041 SGTC_597 k018-0003 82.8 µM 0.488276347260375 0.316767688780503 no 1064 0.31267705638588 1597 6786234 SGTC_929 2805-0021 398 µM 0.488192467683147 0.316794046877188 no 1065 0.312706759658058 1539 3098024 SGTC_1529 apigenin 74 µM 0.488004555345487 0.316853099329043 no 1066 0.312773307222865 1582 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_3228 9131799 49.47 µM 0.487074749029987 0.317145364556674 no 1067 0.31310268003759 1534 17015818 SGTC_184 1494-0393 24.714 µM 0.485414187510659 0.317667611192037 no 1068 0.313691285211767 1457 3090647 SGTC_2185 6113692 200 µM 0.485180572813938 0.317741112169991 no 1069 0.313774130747151 1509 874150 SGTC_666 0272-0154 136 µM 0.484798345572398 0.317861385830261 no 1070 0.313909698207565 1507 6870312 SGTC_1673 st016611 27.3 µM 0.48403513606619 0.318101598887807 no 1071 0.314180466713615 1580 5226799 SGTC_554 4483-2211 187 µM 0.48209575007931 0.31871234665851 no 1072 0.314868964384895 1507 747107 SGTC_1177 0983-0204 23.6 µM 0.479080875305799 0.319662763374711 no 1073 0.315940547291436 1581 766818 SGTC_670 4204-0025 119 µM 0.477422917367961 0.320185927879038 no 1074 0.31653049913143 1590 719039 SGTC_3187 9109394 49.47 µM 0.476537567284414 0.320465444465384 no 1075 0.316845725025926 1440 17098090 SGTC_440 fluspirilene 35.1 µM 0.476248877888829 0.320556609509715 no 1076 0.316948540674739 1594 3396 An atypical antipsychotic. SGTC_2352 9027995 87.8 µM 0.474000289807913 0.321267059964006 no 1077 0.317749850281134 1551 2997347 SGTC_2278 7948257 134.34 µM 0.473437727666824 0.321444906201724 no 1078 0.317950459375028 1609 1247028 SGTC_2397 5161689 200 µM 0.47217803584135 0.321843288771961 no 1079 0.318399857935268 1599 2259942 SGTC_843 0310-0051 143 µM 0.471352615331391 0.322104442445076 no 1080 0.318694474034125 1540 2065037 SGTC_2000 st075254 36.4 µM 0.469903346984007 0.322563186993153 no 1081 0.319212036471811 1493 17234175 SGTC_3151 9099821 49.47 µM 0.468270450368102 0.323080380153576 no 1082 0.319795598589173 1483 17174189 SGTC_1828 st055811 49 µM 0.467605593347258 0.323291060783154 no 1083 0.320033332129389 1579 5877589 SGTC_1857 st056007 79.3 µM 0.466703860895713 0.323576893325923 no 1084 0.32035588353795 1530 619834 SGTC_2485 5633444 17.78 µM 0.466540010917652 0.323628841928043 no 1085 0.320414507568586 1474 5724239 SGTC_857 0438-0306 1.35 µM 0.463435468132314 0.324613785148883 no 1086 0.321526130231715 1544 4686136 SGTC_1340 1486-1359 257 µM 0.461154881493341 0.325338103875945 no 1087 0.322343744661885 1551 4309068 SGTC_131 0141-0277 33.849 µM 0.459785665318813 0.325773286992147 no 1088 0.322835036678046 1618 1547771 SGTC_2679 rapamycin 1 nM 0.459056019252838 0.326005290189674 no 1089 0.323096969291356 1548 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2 SGTC_947 3447-0010 211 µM 0.457201971470385 0.32659511870906 no 1090 0.323762940729435 1518 748350 SGTC_1127 asiatic acid 681.4 nM 0.456916856534618 0.326685860883669 no 1091 0.323865403773978 1510 470603 A kinase inhibitor which arrests cells at G2/M. SGTC_680 0417-1641 114 µM 0.456627917421559 0.326777830621816 no 1092 0.323969254749282 1513 2835990 SGTC_1600 coumarin 106 71.1 µM 0.456113180872043 0.326941698086043 no 1093 0.324154296158645 1603 100336 A hepatotoxic, DNA x-linker. SGTC_627 1391-0720 175 µM 0.45542693524909 0.327160217733124 no 1094 0.32440106052352 1533 997839 SGTC_765 1319-0117 244 µM 0.453662720306143 0.327722264579964 no 1095 0.325035801460609 1488 3487746 YGL099W LSG1 SGTC_1250 0485-0349 40.2 µM 0.450146232771158 0.328843717724004 no 1096 0.326302501165913 1539 6842794 YDL195W SEC31 SGTC_3246 9135460 32.98 µM 0.447021973322165 0.329841379080502 no 1097 0.327429597344703 1599 41446951 SGTC_1370 2001-0092 44.6 µM 0.446816678981295 0.32990697767167 no 1098 0.327503713815223 1722 790957 SGTC_2132 5317594 122.667 µM 0.442222433005949 0.331376362246765 no 1099 0.329164127184251 1608 794577 SGTC_1495 4469-0029 237 µM 0.441691897475436 0.331546212072462 no 1100 0.329356086858638 1544 793680 SGTC_2270 7924575 90.91 µM 0.441385088206107 0.331644452223124 no 1101 0.329467117879033 1689 1262135 SGTC_1237 0330-0133 46.1 µM 0.440670747289092 0.331873228633564 no 1102 0.329725688528153 1546 X1237 YHR072W ERG7 SGTC_1814 st052110 31.539 µM 0.440191643623731 0.332026702575038 no 1103 0.329899155745842 1659 674163 SGTC_1817 st052116 64.4 µM 0.438397653971282 0.332601631434708 no 1104 0.330549023403839 1613 4361398 SGTC_321 4534-3890 65.3 µM 0.437063172493267 0.33302955502416 no 1105 0.33103276725761 1647 699746 SGTC_2965 9082772 38.63 µM 0.436038612671153 0.333358244747626 no 1106 0.331404357388432 1717 16459634 SGTC_1138 3761-0006 1.03 µM 0.435610075582251 0.333495761998934 no 1107 0.331559829647997 1588 12061087 SGTC_650 1328-0195 38 µM 0.435140381846068 0.333646512094375 no 1108 0.331730266783433 1623 2780821 SGTC_408 cantharidin 100 µM 0.435094696738289 0.333661176347419 no 1109 0.33174684633671 1593 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_323 4013-0906 34.3 µM 0.434182367808206 0.333954073804586 no 1110 0.332078008013552 1668 2910086 SGTC_739 1486-1183 203 µM 0.433343413276256 0.334223504182728 no 1111 0.332382651693817 1687 4346692 SGTC_900 1112-0045 141 µM 0.432487780076172 0.334498378925245 no 1112 0.332693465881019 1516 56211 YIL048W NEO1 SGTC_2668 2',4'-dihydroxychalcone 15.08 µM 0.432442823413398 0.334512823843638 no 1113 0.332709799856509 1621 5357218 A potent inhibitor of glutathione S-transferases. SGTC_1641 st009299 47.1 µM 0.432383762962277 0.334531800789038 no 1114 0.332731258603626 1598 4046054 SGTC_3128 9127691 49.47 µM 0.431359173362666 0.334861082942458 no 1115 0.333103615342224 1589 41316314 SGTC_265 mycophenolic acid 32.932 µM 0.429596368690868 0.33542790945522 no 1116 0.333744639528825 1644 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1 SGTC_2437 5741531 144.16 µM 0.428351830505507 0.335828314165125 no 1117 0.334197494458071 1699 2262990 SGTC_2123 5259487 200 µM 0.427661307449962 0.336050556283315 no 1118 0.334448861955358 1694 2173474 SGTC_1072 oxiconazole 14.9 nM 0.425282505136704 0.336816602910252 no 1119 0.335315372727402 1611 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_3110 9122132 49.47 µM 0.425113064138844 0.33687119394352 no 1120 0.335377127401021 1667 918317 SGTC_2158 5657123 3.6195 µM 0.424014548573219 0.337225200463688 no 1121 0.335777601572748 1603 2858827 SGTC_914 3820-6779 408 µM 0.420485516553922 0.338363436986665 no 1122 0.337065403861324 1536 2893481 SGTC_2216 7189485 200 µM 0.4201091550559 0.338484914191599 no 1123 0.337202857494795 1665 731273 SGTC_3280 9140961 49.47 µM 0.419311424601733 0.338742451099234 no 1124 0.337494274090834 1579 4901226 SGTC_1614 st002383 48.6 µM 0.418950717299704 0.33885892552799 no 1125 0.337626075045688 1599 1947235 SGTC_2778 tioconazole 65.09 nM 0.416390533727869 0.339686065522655 no 1126 0.338562127118498 1560 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_828 2074-0507 139 µM 0.41409237798828 0.340429208247871 no 1127 0.339403227303781 1701 X828 SGTC_1666 st014829 29 µM 0.41329174503128 0.340688250564386 no 1128 0.339696438599486 1576 3858230 SGTC_2427 5545055 42.75 µM 0.412223500856089 0.341033994680752 no 1129 0.340087806727743 1651 5372858 SGTC_1610 st001799 48.1 µM 0.411219565266339 0.341359046636691 no 1130 0.3404557715221 1542 621897 SGTC_781 4335-2806 94.4 µM 0.410642043559551 0.341546088643834 no 1131 0.340667514976566 1737 845254 SGTC_2560 caryophyllene 100 µM 0.410187896363939 0.341693200675487 no 1132 0.340834059486523 1605 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor. SGTC_1762 st045503 25.4615 µM 0.409469122944613 0.341926082296676 no 1133 0.341097710924536 1594 4645554 SGTC_2091 4-phenylthiadiazole 200 µM 0.406667611838804 0.342834341598001 no 1134 0.342126065731299 1633 270010 SGTC_1026 k007-1105 30.6 µM 0.405894649227655 0.343085098914915 no 1135 0.342410004878963 1615 7066794 SGTC_273 hydroxyurea 18.1 mM 0.404179570389856 0.343641735479638 no 1136 0.343040337822936 1638 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12 SGTC_3090 9117696 49.47 µM 0.403525808424485 0.343854006230263 no 1137 0.343280726300778 1725 7923821 SGTC_2936 9038235 15.59 µM 0.400757517941047 0.344753390656965 no 1138 0.344299329438794 1598 4749415 SGTC_1907 st060210 83.7 µM 0.398900580617126 0.345357179770847 no 1139 0.344983230678835 1708 688793 SGTC_3208 9114115 49.47 µM 0.397835065019608 0.345703813477597 no 1140 0.345375883987382 1540 650895 SGTC_213 1246-0773 967 nM 0.397228603062102 0.345901165582567 no 1141 0.345599445740486 1657 6251622 SGTC_572 0960-0087 17.7 µM 0.396888100092173 0.346011988875615 no 1142 0.345724989909785 1556 6796365 SGTC_1664 st014217 9.02 µM 0.395839140660092 0.346353475935935 no 1143 0.346111850077141 1681 3982782 SGTC_545 4218-0007 221 µM 0.395144503391321 0.346579682764434 no 1144 0.346368123351495 1645 2840508 SGTC_846 0335-0850 148 µM 0.394101780458782 0.346919345484931 no 1145 0.346752948276821 1637 6819598 SGTC_895 0964-0006 13.7 µM 0.393696187584356 0.347051498956557 no 1146 0.346902678197193 1680 6738897 SGTC_158 k038-0087 26.446 µM 0.392544424208386 0.347426876969494 no 1147 0.347327997016158 1663 X158 SGTC_2254 7938975 95.19 µM 0.392325274483545 0.347498318313594 no 1148 0.347408945591513 1745 2969277 SGTC_467 ro 31-8220 72.8 µM 0.392294210095366 0.347508445534734 no 1149 0.347420420583852 1721 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7 SGTC_1344 1488-0097 29.1 µM 0.391073507038725 0.347906489901918 no 1150 0.347871451343046 1661 747966 SGTC_992 3909-8734 162 µM 0.390652471707858 0.348043819156711 no 1151 0.348027067318076 1619 4288319 SGTC_1870 st057514 26.5 µM 0.390144003520353 0.348209692988686 no 1152 0.348215032871164 1616 5393161 SGTC_969 1313-0238 134 µM 0.38919606894283 0.34851900822161 no 1153 0.348565555601412 1645 5212874 SGTC_2229 7354935 190 µM 0.386975432595733 0.349244005799107 no 1154 0.349387197861751 1687 318112 SGTC_1375 2910-0797 186 µM 0.385811346121259 0.349624279061256 no 1155 0.349818195844377 1665 742508 SGTC_375 3970-0961 9.27 µM 0.384594544511212 0.350021934179088 no 1156 0.35026891833223 1662 2898222 SGTC_2518 prenyletin 46.28 µM 0.382808504400554 0.350605916368671 no 1157 0.350930877678163 1742 3873459 A coumarin with calcium channel inhibitory activity. SGTC_797 k781-0471 270 µM 0.382423178567591 0.350731952867846 no 1158 0.351073750277036 1716 23738129 SGTC_3268 9137683 49.47 µM 0.380560087396502 0.351341584225929 no 1159 0.351764851096879 1647 1953228 SGTC_877 0771-0151 33.1 µM 0.378302108230392 0.352080941688946 no 1160 0.352603089729086 1686 6166523 SGTC_105 0111-0055 734.78 µM 0.377587369581925 0.352315093944508 no 1161 0.352868574448484 1666 5179370 SGTC_2830 7992007 71.43 µM 0.377561596258599 0.352323538471341 no 1162 0.352878149110149 1615 1952075 SGTC_856 0433-0016 11.3 µM 0.375008169657989 0.353160518827913 no 1163 0.353827195402992 1660 3911780 SGTC_1700 st030840 7.9285 µM 0.374106568245833 0.353456222180889 no 1164 0.354162516092273 1787 5499307 SGTC_1488 4013-0813 75.9 µM 0.372409378967723 0.354013098924079 no 1165 0.354794035959693 1653 2910057 SGTC_2476 5806916 10.51 µM 0.372192486367378 0.35408428762292 no 1166 0.354874769957639 1702 2870194 SGTC_1064 honokiol 6.76 µM 0.371379633728593 0.354351128259488 no 1167 0.355177396297544 1678 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis. SGTC_1480 1070-0044 41.2 µM 0.371277686523243 0.354384600208391 no 1168 0.35521535785737 1731 3124987 SGTC_34 0469-0683 81.75 µM 0.369667251872397 0.354913497328311 no 1169 0.355815217584256 1738 3690923 SGTC_182 3448-4371 550.524 µM 0.369292848519351 0.355036498565619 no 1170 0.355954727741215 1848 3491403 SGTC_3022 9087993 49.47 µM 0.369093796880338 0.355101898357439 no 1171 0.356028906207347 1714 17173644 SGTC_1101 ebselen 5.29 µM 0.368903992611888 0.355164263837726 no 1172 0.356099643629959 1819 3194 A potent scavenger of hydrogen peroxide and hydroperoxides. SGTC_3049 9092223 49.47 µM 0.368192561565152 0.355398058842306 no 1173 0.356364828188951 1686 8623917 SGTC_1446 4239-0190 62 µM 0.366566212434836 0.355932724368489 no 1174 0.356971307459397 1660 1340085 SGTC_713 1488-1073 324 µM 0.366060025240085 0.356099192314077 no 1175 0.357160142787993 1752 3312542 SGTC_1283 0922-0125 16.4 µM 0.364355212425062 0.35666004954175 no 1176 0.357796387754854 1753 3360884 SGTC_2239 6685329 187.64 µM 0.36350571463176 0.356939637089463 no 1177 0.358113572403783 1668 805680 SGTC_198 3454-2873 16.191 µM 0.361624802398217 0.357558958058172 no 1178 0.3588162138474 1708 710957 SGTC_2877 9040724 71.43 µM 0.358331017692581 0.358644393475758 no 1179 0.360047804189809 1817 6463895 SGTC_1473 k844-0725 134 µM 0.357000913934178 0.359083040937578 no 1180 0.360545560770119 1742 54682906 SGTC_343 4130-2827 29.8 µM 0.356646663357691 0.359199898613381 no 1181 0.360678169692056 1659 1118244 SGTC_1450 4112-4260 37.6 µM 0.354489542992617 0.359911758211599 no 1182 0.361486019699012 1812 1633175 SGTC_300 r073-0011 5.04 µM 0.353904564396578 0.360104887728698 no 1183 0.361705203124047 1736 2735780 SGTC_476 mead acid 10 µM 0.353826818828585 0.360130557962516 no 1184 0.361734336735747 1703 5312531 An omega 9 fatty acid. SGTC_1975 st070967 30.8 µM 0.350659833983931 0.361176776193958 no 1185 0.362921781097289 1821 261391 SGTC_2730 imipramine 71.33 µM 0.350647018877504 0.361181011800074 no 1186 0.362926588741613 1781 3696 A tricyclic antidepressant. SGTC_2892 9047358 58.44 µM 0.348767053152144 0.361802555913849 no 1187 0.363632099948709 1695 6466771 SGTC_2014 4013930 200 µM 0.34875493219628 0.361806564463897 no 1188 0.363636650189697 1779 64556 SGTC_1192 1488-0095 21.4 µM 0.348493340838121 0.361893079656222 no 1189 0.363734857008856 1715 915875 SGTC_1515 3460-0031 42.1 µM 0.347813566752085 0.362117931947783 no 1190 0.363990100141623 1744 2876596 SGTC_3001 9076041 71.4286 µM 0.347800704880377 0.362122186792728 no 1191 0.363994930128826 1682 16004211 SGTC_2333 9017922 200 µM 0.346932983393446 0.36240927767908 no 1192 0.364320833318341 1834 3163164 SGTC_3148 9097893 49.47 µM 0.344914364686989 0.363077449059865 no 1193 0.365079375546892 1567 17174100 SGTC_2217 6934799 96.0675 µM 0.342391039331159 0.363913266709796 no 1194 0.366028315515698 1777 675606 SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM 0.341677673266243 0.364149677287061 no 1195 0.366296738061231 1870 5024745 SGTC_1296 1068-0102 11.9 µM 0.33904349215853 0.365023096169803 no 1196 0.367288483227706 1787 767053 SGTC_494 Boc-Gly-Val-Val-CHO 140 µM 0.338858054379299 0.365084608472118 no 1197 0.367358332317588 1719 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA. SGTC_1178 0988-0033 191 µM 0.338180754980349 0.365309307633335 no 1198 0.367613488841216 1756 5392207 SGTC_1173 0443-0020 122 µM 0.337807090974757 0.36543329327181 no 1199 0.367754282939679 1700 5331295 SGTC_636 0kpi-0074 126 µM 0.337468293182543 0.365545722091593 no 1200 0.367881955045414 1723 616434 SGTC_2043 5101342 149 µM 0.337111383543922 0.365664173757437 no 1201 0.368016468184305 1744 678451 SGTC_2243 6634756 200 µM 0.337013915040597 0.365696523966846 no 1202 0.368053205210501 1828 885676 SGTC_696 1560-0013 611 µM 0.336771496702385 0.365776987782571 no 1203 0.36814458076816 1787 1650269 SGTC_170 4197-0004 226 µM 0.336598361403788 0.365834458695191 no 1204 0.368209845804171 1786 218692 SGTC_2735 sertaconazole 140 nM 0.336383373565998 0.365905826422611 no 1205 0.368290892855874 1810 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C SGTC_1105 epirubicin 18.1 µM 0.334043039675647 0.366683027360036 no 1206 0.369173540611827 1677 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_888 0916-0002 6.97 µM 0.333494572337768 0.366865246973015 no 1207 0.369380492921277 1808 2802138 YIL048W NEO1 SGTC_3057 9095946 49.47 µM 0.331216019506324 0.367622580987422 no 1208 0.370240660346144 1746 24540043 SGTC_2932 9016711 44.54 µM 0.33060140656191 0.367826951296169 no 1209 0.370472791812291 1887 7117328 SGTC_2360 9040895 200 µM 0.328919553893604 0.368386389966428 no 1210 0.371108247028595 1699 4914414 SGTC_1853 st056710 91.2 µM 0.328918766324758 0.368386652002812 no 1211 0.37110854467861 1884 269167 SGTC_2869 9037858 32.47 µM 0.32891231675875 0.368388797875872 no 1212 0.371110982199741 1686 27187042 SGTC_1960 st011366 51.8 µM 0.328564125164381 0.36850465284184 no 1213 0.371242583900187 1717 3972846 SGTC_612 0302-0167 22.4 µM 0.328320496989152 0.368585723177482 no 1214 0.371334674003329 1831 235821 SGTC_2849 9019321 12.99 µM 0.327998864719135 0.368692759313755 no 1215 0.371456260504011 1762 16489627 SGTC_1496 4469-0713 57.4 µM 0.326059491190318 0.369338379873678 no 1216 0.372189672463078 1844 746691 SGTC_3039 9090270 49.47 µM 0.324537019959421 0.369845471417526 no 1217 0.372765749851366 1878 17173750 SGTC_2539 epi(13)torulosol 80 µM 0.324326655594343 0.36991555558217 no 1218 0.372845370586892 1686 6708597 SGTC_2223 6903751 107.57 µM 0.321302042602777 0.370923700340455 no 1219 0.373990754321177 1813 5598863 SGTC_1782 st039423 80.636 µM 0.320115162007232 0.371319546447048 no 1220 0.374440516164863 1690 2068169 SGTC_3190 9110366 49.47 µM 0.319953545347704 0.371373459062368 no 1221 0.37450177313885 1884 17123768 SGTC_2517 totarol 10 µM 0.317502379925041 0.37219143569547 no 1222 0.375431216953014 1691 460178 An antibacterial membrane disruptor. YGL001C ERG26 SGTC_2214 7179297 48.276 µM 0.316697249049189 0.372460241415109 no 1223 0.375736668187076 1817 769744 SGTC_209 4077-0173 175.592 µM 0.315317824196027 0.372920928667583 no 1224 0.376260176511694 1780 15993494 SGTC_1816 st051957 91.6 µM 0.314974753186424 0.373035532529518 no 1225 0.376390411487042 1766 674121 SGTC_2677 mitomycin C 100 µM 0.314263729587685 0.373273087780957 no 1226 0.376660371658353 1771 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_3352 9151559 45.5865 µM 0.310276965902678 0.374605968281749 no 1227 0.378175172964549 1728 17159339 SGTC_2153 5569715 200 µM 0.310197772579508 0.374632459945526 no 1228 0.378205282136634 1784 2054701 SGTC_1576 erythromycin ethylsuccinate 23.2 µM 0.309296362843104 0.374934040214563 no 1229 0.378548048728326 1771 3256 An antibiotic and ribosome inhibitor. SGTC_1546 5-methoxyflavanone 78.7 µM 0.307628766039569 0.375492161482802 no 1230 0.379182414436125 1916 147795 SGTC_1300 1094-0077 113 µM 0.307465650089683 0.375546768119156 no 1231 0.379244482408932 1739 5532636 SGTC_2507 purpurin 79.67 µM 0.305141255943659 0.376325180387126 no 1232 0.380129285444753 1667 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1 SGTC_1000 4048-0884 8.67 µM 0.305034186387237 0.376361048872198 no 1233 0.380170057661641 1797 13040088 SGTC_3040 9091894 49.47 µM 0.30002824755403 0.378039234021216 no 1234 0.382077804583773 1860 25236966 SGTC_3283 9109332 35.8195 µM 0.299988927428373 0.378052424814969 no 1235 0.382092800761966 1746 17027281 SGTC_1761 st044296 37 µM 0.298265681765382 0.378630664599591 no 1236 0.382750197426147 1726 1826700 SGTC_1338 1486-1223 76 µM 0.296928518770427 0.379079540664649 no 1237 0.38326054135181 1861 3444526 SGTC_3232 9132874 49.47 µM 0.295526095763883 0.379550499290454 no 1238 0.383796010257277 1734 3784940 SGTC_366 0181-0206 4.31 µM 0.294393978231828 0.379930814961517 no 1239 0.384228433910566 1944 274874 SGTC_1705 st027868 56.3335 µM 0.293416096159577 0.380259411356916 no 1240 0.384602061827314 1882 292948 SGTC_1979 st071809 45.3 µM 0.290471032267001 0.381249558491361 no 1241 0.385727954407855 1865 4976333 SGTC_1517 deoxycholic acid methyl ester 49.2 µM 0.287415279375934 0.382277742180645 no 1242 0.386897181638945 1763 229346 A bile salt which induces apoptosis. SGTC_814 3342-0569 96 µM 0.287097169109729 0.382384826111917 no 1243 0.387018959852118 1821 4346283 SGTC_2578 7,8-dihydroxyflavone 64.44 µM 0.286041907358112 0.382740118178562 no 1244 0.387423012220803 1676 1880 Intensifies effect of antibiotics on Staphylococcus aureus. SGTC_104 0074-0074 590.992 µM 0.28516908054265 0.383034061517107 no 1245 0.387757303713868 1892 3943124 SGTC_1654 st012436 41.8 µM 0.284498727457847 0.383259863188411 no 1246 0.388014104552875 1906 4323132 SGTC_1800 st050079 29.0735 µM 0.283871978717135 0.383471013057743 no 1247 0.388254245618017 1821 3645560 SGTC_2628 lathosterol 100 µM 0.28320900750552 0.383694403846731 no 1248 0.388508311957551 1811 6710616 SGTC_3279 9140807 49.47 µM 0.282602675611853 0.383898743642155 no 1249 0.388740714533858 1799 45595718 SGTC_2317 5986382 200 µM 0.280740363050452 0.384526562873681 no 1250 0.389454773981135 1903 877883 SGTC_3269 9137823 49.47 µM 0.279365816576722 0.384990141788814 no 1251 0.389982050780213 1778 17682936 SGTC_2329 6138490 200 µM 0.279313870081145 0.385007664468953 no 1252 0.390001981462151 1805 720019 SGTC_140 0062-0056 502.533 µM 0.279094603145841 0.385081630551347 no 1253 0.390086112354839 1749 3758964 SGTC_2934 9036370 36.88 µM 0.276168755885373 0.38606901602048 no 1254 0.391209226780381 1922 6462800 SGTC_1766 st045414 44.774 µM 0.275268641966795 0.386372926230403 no 1255 0.391554927132898 1815 253960 SGTC_3065 9113888 49.47 µM 0.27494034963115 0.386483786664211 no 1256 0.391681033369519 1893 16648368 SGTC_2652 actinonin 100 µM 0.27485922536445 0.38651118279642 no 1257 0.391712197215985 1874 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase. SGTC_1365 1672-3266 55.4 µM 0.274471342102258 0.386642181024828 no 1258 0.391861211978105 1923 6415873 SGTC_28 pentachloropyridine N-oxide 1.606 µM 0.272487684272629 0.387312315332303 no 1259 0.392623529832988 1916 140250 A respiratory chain inhibitor. SGTC_799 1310-0557 151 µM 0.271485012548561 0.387651173435095 no 1260 0.393009012635631 1848 5354492 SGTC_1721 st082152 9.2685 µM 0.271381186836657 0.387686266766972 no 1261 0.393048935018822 1814 5296051 SGTC_2213 7173844 200 µM 0.271021476741022 0.387807856709404 no 1262 0.393187257087603 1837 892728 SGTC_530 4358-1714 28 µM 0.270015726148377 0.388147880931726 no 1263 0.393574077552717 1880 1564641 SGTC_2888 9058547 12.99 µM 0.269735058410769 0.388242784414355 no 1264 0.393682043582796 1785 16476514 SGTC_2497 7-hydroxyflavone 100 µM 0.269327253011534 0.38838068943487 no 1265 0.393838930933501 1929 5281894 SGTC_1305 1181-0477 144 µM 0.266208013224631 0.389435967658836 no 1266 0.39503950598534 1949 6252086 SGTC_1482 3346-2049 8.48 µM 0.265351192639106 0.389725984047422 no 1267 0.395369465704745 1918 3826804 SGTC_2025 5147754 141 µM 0.264408316551116 0.390045199447762 no 1268 0.39573265190904 1946 315777 YLR208W SEC13 SGTC_2423 st077119 87.2 µM 0.263918215722465 0.390211154834276 no 1269 0.39592146951185 1881 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae). SGTC_3215 9129942 49.47 µM 0.262629780590036 0.390647533393245 no 1270 0.396417971996953 1992 17682944 SGTC_316 k060-0003 58.6 µM 0.262438031890131 0.39071248832196 no 1271 0.396491877338011 1924 6152314 SGTC_1849 st056239 19.2 µM 0.262387728702141 0.390729529046786 no 1272 0.39651126621715 1737 5393181 SGTC_3156 9099931 49.47 µM 0.26223334740458 0.390781828617082 no 1273 0.396570772598546 1833 18111053 SGTC_465 cgp-37157 41 µM 0.262169200696807 0.390803560102761 no 1274 0.396595498701406 1943 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange. SGTC_2719 novobiocin 32.65 µM 0.261995151793561 0.390862525739063 no 1275 0.396662589992455 1938 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication. SGTC_1574 spiramycin 23.7 µM 0.261889997847691 0.390898151823881 no 1276 0.396703125565593 1825 6419898 An antibiotic and protein synthesis inhibitor. SGTC_1268 0828-0275 2.46 µM 0.260425624587996 0.391394375520267 no 1277 0.397267739560717 1902 745337 SGTC_1706 st031321 9.9705 µM 0.259809289405551 0.391603282373351 no 1278 0.397505442526008 1943 6103185 SGTC_405 ebelactone b 50 µM 0.258758154946157 0.391959636569621 no 1279 0.397910922990876 1839 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).  SGTC_186 3455-3465 67.277 µM 0.257919559890268 0.392244000967109 no 1280 0.398234494421715 1866 755278 SGTC_1693 xanthone 101.9 µM 0.257471648436167 0.392395909629327 no 1281 0.398407349494281 1905 7020 An insecticide. SGTC_1292 0kpi-0043 232 µM 0.254213341233596 0.39350145294957 no 1282 0.399665372140413 1837 3333905 SGTC_2634 4'-methoxyflavone 100 µM 0.252702502629439 0.394014372445449 no 1283 0.400249056911372 1807 77793 From seeds of Psoralea corylifolia (Fabaceae) SGTC_2826 7992541 19.48 µM 0.251952839789138 0.39426894623016 no 1284 0.400538758207045 1926 2985066 SGTC_122 0236-0016 402.397 µM 0.251544401979133 0.394407664344689 no 1285 0.400696618818717 1866 6808838 SGTC_510 ag-490 170 µM 0.250640679668108 0.394714643972478 no 1286 0.4010459637717 2013 5328779 SGTC_3252 9135871 49.47 µM 0.250594994503048 0.39473016421056 no 1287 0.401063626036756 1927 17682838 SGTC_3332 9141069 11.198 µM 0.249380056544084 0.395142966123625 no 1288 0.401533405247317 1791 17332883 SGTC_150 3970-0969 77.2 µM 0.249236888549599 0.395191618362664 no 1289 0.401588773304156 1889 6615640 SGTC_1171 0368-0077 21.4 µM 0.249205035466975 0.395202443097699 no 1290 0.401601092270892 1847 3239779 SGTC_3343 9148379 18.9835 µM 0.248467854001675 0.395452984412086 no 1291 0.401886219569092 1973 1955036 SGTC_334 1502-1024 68.5 µM 0.248252109912466 0.395526316203138 no 1292 0.40196967502754 1895 3296216 SGTC_3325 9138760 55.175 µM 0.247942751653602 0.395631474067526 no 1293 0.402089350695243 1808 43844959 SGTC_1834 st055981 52.8 µM 0.24637190305423 0.396165558107251 no 1294 0.402697177061583 1967 471719 YDL150W RPC53 SGTC_1571 st070080 73.4 µM 0.245614034609987 0.396423300993918 no 1295 0.402990511969922 1937 4315245 SGTC_1987 st072290 61.9 µM 0.243725289459372 0.397065839630674 no 1296 0.40372179286795 1874 54697379 SGTC_2489 cantharidin 73.42 µM 0.24224632778156 0.397569167852746 no 1297 0.404294649729932 1794 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_250 brefeldin a 552.239 µM 0.242229896802673 0.397574760691807 no 1298 0.404301015214281 1888 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.  SGTC_1463 k081-0032 34.1 µM 0.242112131560182 0.397614846688942 no 1299 0.404346639093139 1911 977755 SGTC_3063 1327-0034 4 µM 0.240723197585399 0.398087706044522 no 1300 0.404884829252615 1951 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_2142 5622915 118.518 µM 0.240704048696064 0.398094226287442 no 1301 0.404892250407265 1869 5322196 SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM 0.238436646484406 0.398866482902433 no 1302 0.405771223551121 1924 676296 Flavone; oxidizing agent. SGTC_737 1950-0117 57.9 µM 0.238200075383839 0.398947079742219 no 1303 0.405862959326981 2000 5393513 SGTC_233 rapamycin 362 pM 0.237772090647798 0.399092899779885 no 1304 0.406028933186509 1997 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C SGTC_981 1488-1094 54.9 µM 0.235593085661109 0.399835533445359 no 1305 0.406874219649816 1876 3449522 SGTC_2458 5808907 16.39 µM 0.233800323305323 0.400446802431781 no 1306 0.407569999284615 2018 2731747 SGTC_1316 1272-0050 65.9 µM 0.233668660798059 0.400491704354245 no 1307 0.407621109656302 1893 7340392 SGTC_768 0384-0033 77.3 µM 0.23328450166585 0.400622724743385 no 1308 0.407770246258248 1827 3965305 YMR134W ERG29 SGTC_3305 9127027 53.8275 µM 0.232152167373672 0.401008980952655 no 1309 0.408209913877622 1891 41905295 SGTC_2079 5212404 121 µM 0.231754730982705 0.401144575432114 no 1310 0.408364259618684 2031 758462 SGTC_2271 7849410 118.62 µM 0.230777571315476 0.401478006312907 no 1311 0.408743803218409 2055 972430 SGTC_1352 1496-0991 99 µM 0.22933950622968 0.401968839874599 no 1312 0.409302525042597 1852 3000039 SGTC_653 0203-0016 55.2 µM 0.228877814403044 0.402126455174323 no 1313 0.409481942220294 1937 295302 SGTC_3293 9120939 62.045 µM 0.228349822773344 0.402306723831439 no 1314 0.409687147275295 1945 934087 SGTC_945 3381-0768 11.3 µM 0.228245255861566 0.402342427880344 no 1315 0.409727790362039 2006 1126236 YIL048W NEO1 SGTC_418 lividomycin a 100 µM 0.227972734706287 0.402435483214598 no 1316 0.409833718492765 1998 72394 An antibiotic. SGTC_2570 licareol 100 µM 0.227410151395359 0.402627600931793 no 1317 0.410052413694849 1868 443158 SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM 0.226873476762128 0.402810892960259 no 1318 0.410261063394447 1979 16725076 SGTC_714 4296-0578 26.1 µM 0.226837781041244 0.402823084980423 no 1319 0.410274942167396 2030 1589775 SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM 0.226276198022556 0.403014908398599 no 1320 0.41049330477846 1910 364106 SGTC_1243 0416-0003 5.65 µM 0.225723521843988 0.40320371224387 no 1321 0.410708231200002 1877 2141977 SGTC_2018 5133068 143 µM 0.225385503752536 0.403319196258241 no 1322 0.410839693939576 1894 785362 SGTC_3135 9127742 49.47 µM 0.225377944307748 0.403321779041966 no 1323 0.410842634090023 1864 3643468 SGTC_1931 st074438 57.1 µM 0.225370861236186 0.403324199070342 no 1324 0.410845388965675 2021 2787313 SGTC_1724 st037281 8.293 µM 0.224962766254519 0.403463636556872 no 1325 0.411004120031254 1851 574124 YDL195W SEC31 SGTC_3295 9122362 53.5725 µM 0.219401763957824 0.405364930213738 no 1326 0.413168548031907 1873 4730473 SGTC_459 nigericin 15.3 µM 0.218473133180892 0.405682645919726 no 1327 0.41353024467131 1938 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification. SGTC_1299 1079-1439 3.74 µM 0.217851931586436 0.405895214503791 no 1328 0.413772240300361 1897 323161 SGTC_1092 toremifene 6.32 µM 0.217802162615673 0.405912246118131 no 1329 0.413791629745796 2041 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_2751 anetholtrithion 17.25 µM 0.21588542411565 0.40656831513808 no 1330 0.414538529537325 2007 2194 A chloretic substance that stimulates the liver to produce bile. SGTC_3126 9127922 49.47 µM 0.214877862224131 0.406913292824829 no 1331 0.414931272564478 1953 45595682 SGTC_3086 9117350 49.47 µM 0.214402697347523 0.407076008936302 no 1332 0.415116519196895 1973 2679265 SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM 0.213399234141095 0.407419688922166 no 1333 0.415507788906865 1885 4330530 SGTC_1233 0325-0408 14.2 µM 0.21278347809239 0.407630616892984 no 1334 0.415747925607929 1993 12874 SGTC_3349 9149703 23.001 µM 0.211037269800125 0.408228928096968 no 1335 0.416429094559188 2012 4910494 SGTC_1076 itraconazole 331 nM 0.210991663104901 0.408244557397998 no 1336 0.416446888401234 2035 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1 SGTC_3029 9088683 49.47 µM 0.210966867214076 0.408253054949375 no 1337 0.416456562801883 1949 25236615 SGTC_2646 retinol 96.75 µM 0.209733005497124 0.408675953750933 no 1338 0.416938031873452 1975 445354 A vitamin A analog and teratogen. SGTC_207 4185-0010 4.486 µM 0.208520268795913 0.409091715724704 no 1339 0.417411379119364 2035 3761753 SGTC_74 000s-0487 160.283 µM 0.208128388899899 0.409226085622597 no 1340 0.417564360673482 2079 677548 SGTC_1385 3091-4834 14.1 µM 0.207990140647837 0.409273491476863 no 1341 0.4176183328214 1991 4072814 SGTC_2836 9010338 19.48 µM 0.206612307872289 0.409746028002748 no 1342 0.418156323688034 1799 2994051 SGTC_3077 9117319 49.47 µM 0.206576674431155 0.409758250460678 no 1343 0.418170239216598 2017 17154678 SGTC_2810 7959871 45.46 µM 0.204585452752032 0.410441389016264 no 1344 0.418948011012881 1985 2974535 SGTC_1609 st001574 46.4 µM 0.201840580757925 0.411383531442497 no 1345 0.420020677767858 1893 3960012 SGTC_1167 k781-0610 148 µM 0.201447230719269 0.411518585852567 no 1346 0.420174443654223 1934 4525169 SGTC_1038 k292-0204 154 µM 0.200382975818697 0.411884043995386 no 1347 0.420590536403982 1892 4454212 SGTC_1944 st076371 56.9 µM 0.200204076069545 0.411945484507762 no 1348 0.420660489733995 1877 24208455 SGTC_2561 acetosyringone 100 µM 0.198978154830324 0.412366567298792 no 1349 0.421139916413514 2098 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent. SGTC_802 4112-3352 742 µM 0.198181970786607 0.412640096851084 no 1350 0.421451346474772 2049 704594 SGTC_2865 9030313 51.95 µM 0.195268576690915 0.413641356026664 no 1351 0.422591347848675 1879 42562754 SGTC_2290 7904846 200 µM 0.193984589133738 0.414082808508207 no 1352 0.423093974394566 1920 2962154 SGTC_1190 1486-1332 13 µM 0.19321574134405 0.414347200903937 no 1353 0.423395005604911 2039 4150046 SGTC_2940 9060638 45.86 µM 0.192778995730663 0.414497406859155 no 1354 0.42356602694973 1951 4027022 SGTC_376 3970-0862 59.1 µM 0.191632135835979 0.414891895449842 no 1355 0.424015184125808 2066 3135186 SGTC_363 0455-0021 3.06 µM 0.191301752353119 0.415005554319074 no 1356 0.424144594133222 1963 4597466 SGTC_1543 azetidyl-2-carboxylic acid 198 µM 0.189130644878644 0.415752637534963 no 1357 0.424995211882722 2035 16486 A toxic proline analog. SGTC_2592 piperlongumine 83.33 µM 0.188844902959091 0.415850984745046 no 1358 0.425107188748949 1917 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_2368 9071271 200 µM 0.185067356300324 0.417151641215801 no 1359 0.426588102597772 1921 27209959 SGTC_1149 3909-7961 23.3 µM 0.184913190571955 0.417204741764043 no 1360 0.426648562413845 1907 735261 SGTC_113 0099-0221 2.5 µM 0.184614314909746 0.417307690225849 no 1361 0.426765778636073 2064 89219 SGTC_2773 thioridazine 9.09 µM 0.183429809842913 0.417715751619121 no 1362 0.42723039388982 2112 5452 An antipsychotic. SGTC_2016 5121758 140 µM 0.182769564545823 0.417943244280711 no 1363 0.427489415146316 2074 2795203 SGTC_1658 st012944 20 µM 0.18268514736642 0.417972332859101 no 1364 0.427522535160293 2061 24207260 SGTC_26 0302-0163 425.158 µM 0.181940318250252 0.418229006446799 no 1365 0.42781478156436 1990 3100915 SGTC_2675 theaflavin digallate 100 µM 0.180776185314223 0.418630244929321 no 1366 0.428271628239865 2021 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative. SGTC_2733 amorolfine 100 µM 0.180568649259525 0.418701784712646 no 1367 0.4283530827972 2128 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_509 pifithrin 175 µM 0.179245066156272 0.419158100393736 no 1368 0.428872639507416 2091 4817 A p53 inhibitor. SGTC_2516 gossypol 71.55 µM 0.178767038177315 0.419322931063983 no 1369 0.429060314018509 2073 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_2005 4024620 188 µM 0.178760299206174 0.419325254855879 no 1370 0.429062959863564 2038 236743 SGTC_411 enrofloxacin 100 µM 0.176253331904722 0.420189924149255 no 1371 0.430047461867503 2127 71188 A bacterial gyrase inhibitor. SGTC_1616 st002734 56.1 µM 0.175391707891326 0.420487193051886 no 1372 0.430385927870734 2001 4026101 SGTC_1164 k060-0068 93.7 µM 0.175315705951421 0.420513416660539 no 1373 0.430415785663511 2110 5963676 SGTC_2228 7354201 200 µM 0.174654133494164 0.420741699633201 no 1374 0.430675704938082 2054 753451 SGTC_2035 5154463 94.595 µM 0.171440568275375 0.421850954086549 no 1375 0.431938679039359 2094 2769623 SGTC_2841 9004761 38.96 µM 0.170985254599084 0.422008169070663 no 1376 0.432117679988404 1867 2991039 SGTC_2650 prasterone 100 µM 0.170059498512441 0.422327861132194 no 1377 0.432481672496863 2078 16759247 A steroid and weak partial agonist of the androgen receptor. SGTC_1662 st014054 52 µM 0.169743691689769 0.422436930662742 no 1378 0.43260585582081 2106 2838777 SGTC_2982 9019404 25.97 µM 0.168240116059606 0.422956298807406 no 1379 0.433197191326232 1812 22333232 SGTC_860 0443-0016 25.1 µM 0.168115198616762 0.422999454082141 no 1380 0.43324632637802 2135 5337942 SGTC_337 1315-0038 354 µM 0.167037122449828 0.423371935794551 no 1381 0.433670419873739 2008 1626437 SGTC_2281 7943571 200 µM 0.166323804583808 0.423618429023873 no 1382 0.433951066801283 2164 1244024 SGTC_2794 7785382 27.27 µM 0.166309322436655 0.423623433766454 no 1383 0.43395676498528 2154 2205081 SGTC_1218 1348-1416 30.7 µM 0.165511000961961 0.423899336858638 no 1384 0.434270895866086 2011 6787668 SGTC_764 1951-2361 146 µM 0.165382701564625 0.423943681126238 no 1385 0.43432138417032 1923 5438930 SGTC_461 N-acetylfarnesylcysteine 136 µM 0.165141677474045 0.424026989162155 no 1386 0.434416234726316 2115 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ). SGTC_1635 st007035 42.4 µM 0.16498567483276 0.424080912028935 no 1387 0.434477628682427 2094 3716403 SGTC_2127 5253358 187.912 µM 0.164216040844767 0.424346959533261 no 1388 0.434780536880563 1992 20612 SGTC_1112 tnp00069 1.16933 µM 0.162986119953317 0.424772190790043 no 1389 0.435264681604831 2102 145826 SGTC_1833 st055984 71 µM 0.162709250897633 0.424867927230198 no 1390 0.435373681448785 1984 676288 SGTC_906 1165-0455 526 µM 0.162536958756576 0.42492750505354 no 1391 0.435441513163824 2012 3252859 SGTC_1687 st020778 55.3625 µM 0.162449296156146 0.424957819032509 no 1392 0.435476026811055 2032 4259299 SGTC_1867 st057372 64 µM 0.16126915405391 0.425365958688 no 1393 0.435940708365458 2115 688837 SGTC_957 1187-1561 14.1 µM 0.160819971200135 0.425521324865384 no 1394 0.436117597616176 2128 1538454 SGTC_2087 5276107 200 µM 0.160122610547962 0.425762555240382 no 1395 0.436392245166741 2088 144405 SGTC_2180 6301957 200 µM 0.159972900965207 0.425814346271853 no 1396 0.436451210584139 2122 845462 SGTC_497 capsazepine 133 µM 0.15849403936112 0.426326017201754 no 1397 0.437033758600361 1933 2733484 A calcium channel blocker. SGTC_284 0988-0104 32.6 µM 0.158334056335759 0.426381377135952 no 1398 0.437096786764643 2116 4666532 SGTC_546 peri-Naphthalide 147 µM 0.157808467750411 0.426563260070529 no 1399 0.437303862985707 2081 223824 A penicillin ester. SGTC_738 1315-0003 72.4 µM 0.157306702199776 0.426736913480689 no 1400 0.437501569215349 2118 6251474 SGTC_412 gemfibrozil 100 µM 0.15719130385439 0.426776853099205 no 1401 0.437547040810912 2128 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels. SGTC_254 nsc-64875 3.808 µM 0.156782945617793 0.426918192800012 no 1402 0.437707957021984 2125 56993 SGTC_630 4356-0227 183 µM 0.156753212415476 0.426928484331537 no 1403 0.437719673985864 2101 779312 SGTC_1659 st012954 42.1 µM 0.156437102323655 0.427037902360052 no 1404 0.437844246873297 2080 24207262 SGTC_909 3448-9333 149 µM 0.1543687163991 0.427753989547395 no 1405 0.438659509331684 2006 3344074 SGTC_2989 9073649 71.4286 µM 0.154000962125677 0.42788133319794 no 1406 0.438804488484563 2171 21367202 SGTC_1579 chlormadinone acetate 49.4 µM 0.15305640764361 0.428208442013399 no 1407 0.439176896202756 2134 45114258 A steroidal progestin. SGTC_2473 5854593 8.94 µM 0.150794995400898 0.428991792099469 no 1408 0.440068717107068 2001 2872951 SGTC_3247 9135149 49.47 µM 0.150678326107253 0.429032213797526 no 1409 0.440114735634162 2140 8934436 YOR116C RPO31 SGTC_2356 9061756 188.97 µM 0.150457810864826 0.429108616400088 no 1410 0.440201716913228 2146 20104043 SGTC_1672 st016598 6.51 µM 0.148669096280337 0.429728455818386 no 1411 0.440907373892796 1987 4665860 YNL267W PIK1 SGTC_1039 k821-0043 94 µM 0.147558187561814 0.430113503943466 no 1412 0.441345727635324 2135 15992768 SGTC_1307 1187-1599 12.2 µM 0.147183774248274 0.430243293007426 no 1413 0.441493483694 2024 1538471 SGTC_1567 st069303 68.4 µM 0.146738782465868 0.43039755765155 no 1414 0.44166910297319 2029 5581319 SGTC_1952 st077036 64.1 µM 0.146026156626097 0.430644624718365 no 1415 0.441950369874754 2176 2937007 SGTC_1137 ixabepilone 100 µM 0.145557901630858 0.430806983307357 no 1416 0.442135201783214 2056 154225 A novel microtubule stabilizer. SGTC_1929 genistein trimethyl ether 50.5 µM 0.14361220045311 0.431481743459349 no 1417 0.442903352982351 2188 136420 SGTC_2173 5763948 167 µM 0.142194982277661 0.431973354159478 no 1418 0.443462997540384 2153 2867177 SGTC_115 0527-0192 112.043 µM 0.141952718652241 0.432057402167382 no 1419 0.443558676218017 2023 4233931 SGTC_3188 9110789 49.47 µM 0.14068267012151 0.432498067653552 no 1420 0.444060318082363 2147 849217 SGTC_885 0865-0106 16.8 µM 0.139196690881395 0.433013760633791 no 1421 0.444647361671397 2117 2793380 SGTC_1500 4488-1866 171 µM 0.139089472359414 0.43305097408271 no 1422 0.44468972360138 2157 2900003 SGTC_2115 tiliquinol 12.7705 µM 0.138837632617143 0.433138385058911 no 1423 0.444789227713543 2096 71208 A bioactive hydroxyquinoline. SGTC_2596 sinensetin 100 µM 0.138287269264902 0.43332942188023 no 1424 0.445006693248619 2055 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets. SGTC_383 2324-0395 7.37 µM 0.136940363648049 0.433797012401857 no 1425 0.445538966887658 2100 3146421 SGTC_2853 9015042 58.44 µM 0.136571744708564 0.433924997993334 no 1426 0.445684655824348 2106 6457456 SGTC_1155 4088-0394 48.2 µM 0.13537958145717 0.434338967982246 no 1427 0.446155883569408 2002 2326248 SGTC_1265 0819-1001 68.8 µM 0.133786105060094 0.434892403409813 no 1428 0.446785857484435 2157 3106768 SGTC_1205 4161-2785 76 µM 0.133775477934661 0.434896094780513 no 1429 0.446790059324551 1970 3498106 SGTC_1238 0333-0287 48.8 µM 0.13346964880773 0.43500232807113 no 1430 0.446910983113711 2094 7226 SGTC_2460 5552655 174.22 µM 0.133295423225611 0.435062849444059 no 1431 0.44697987351975 2032 5401989 SGTC_202 3594-0513 34.79 µM 0.127082899333498 0.437221900233578 no 1432 0.449437393035428 2188 708429 SGTC_2227 7312221 64.1025 µM 0.126669740816009 0.437365553092586 no 1433 0.449600898105326 2166 887188 YOR168W | YOR169C GLN4 | YOR169C SGTC_3166 9102297 49.47 µM 0.125095339094002 0.437913039113094 no 1434 0.450224036588372 2048 25237072 SGTC_139 0099-0334 718.624 µM 0.124493981131488 0.438122188123038 no 1435 0.4504620828347 2206 97690 SGTC_2895 9054447 58.44 µM 0.12448471745575 0.438125410114124 no 1436 0.45046574998027 2073 2697450 SGTC_1389 3405-0187 19 µM 0.123045835778478 0.438625915977378 no 1437 0.451035401006042 2050 799890 SGTC_2253 7938677 135.83 µM 0.122802667320716 0.438710510301349 no 1438 0.451131681016693 2198 2301972 SGTC_2404 5161160 200 µM 0.122258689030046 0.438899761571736 no 1439 0.451347073939968 2104 2831543 SGTC_252 miconazole 1.30953 nM 0.122007335883994 0.438987212617571 no 1440 0.451446604241371 2182 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_2788 5282734 71.43 µM 0.1215745567736 0.439137792548407 no 1441 0.45161798237141 2165 743706 SGTC_460 trequinsin 123 µM 0.12055299027537 0.439493268381079 no 1442 0.452022552752268 2213 5537 A vasodilator. SGTC_2095 5432005 200 µM 0.119899809463122 0.439720582155384 no 1443 0.452281257706972 2126 783734 SGTC_2972 9093619 59.92 µM 0.11934248643417 0.439914552131948 no 1444 0.452502012347433 1978 25236256 SGTC_3344 9148862 3.898 µM 0.117079275743958 0.44070238474381 no 1445 0.453398616168661 2165 4905352 SGTC_1568 digitonin 820 nM 0.116174960965973 0.441017246121595 no 1446 0.45375694030887 2218 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1 SGTC_349 k015-0014 24 µM 0.114658327680556 0.441545386173745 no 1447 0.454357972854035 2097 2196908 SGTC_3214 9129694 49.47 µM 0.114496491380873 0.441601748886223 no 1448 0.454422113791039 2191 17158655 SGTC_464 bw-b 70c 158 µM 0.114436830445522 0.44162252729281 no 1449 0.454445759640839 2195 5353454 SGTC_1869 3',7'-dimethoxyflavone 40.3 µM 0.113789898789351 0.441847847658013 no 1450 0.454702173089778 2135 688664 SGTC_1093 fluphenazine 7.97 µM 0.112955336291602 0.442138545911392 no 1451 0.455032982495396 2168 6602611 An atypical antipsychotic. SGTC_1361 1608-0041 5.61 µM 0.112919078094932 0.442151176223555 no 1452 0.455047355467865 2137 X1361 SGTC_548 1436-0017 110 µM 0.112797279870359 0.442193604290793 no 1453 0.455095637464973 2204 9677137 SGTC_2048 5246248 200 µM 0.112184174768438 0.442407187780455 no 1454 0.455338688330773 2232 677046 SGTC_3008 9078912 71.4286 µM 0.110952629802675 0.442836263723363 no 1455 0.455826955327214 2123 16648731 SGTC_17 0960-0276 49.807 µM 0.110896254774564 0.442855906651762 no 1456 0.455849307770786 2213 6821114 SGTC_2663 amphotericin b 100 µM 0.108388349945786 0.4437298852308 no 1457 0.456843821043796 2163 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_983 1491-0821 12.2 µM 0.107870517604572 0.443910378619538 no 1458 0.457049202085285 2212 46495113 SGTC_15 0266-0086 27.098 µM 0.106225662138677 0.444483779285839 no 1459 0.457701655345805 2224 1712902 YIL048W NEO1 SGTC_2332 7982454 138.89 µM 0.106215205775112 0.444487424772909 no 1460 0.457705803364607 2207 2981748 SGTC_2864 9034755 47.6 µM 0.104866194549713 0.444957780802487 no 1461 0.458240991933259 2248 4930451 SGTC_910 3454-3003 490 µM 0.104326078200274 0.4451461234482 no 1462 0.458455291709251 2229 820824 SGTC_1896 st058441 89 µM 0.104236501662957 0.445177360660782 no 1463 0.45849083379819 2074 688759 SGTC_740 k014-0057 261 µM 0.103724731748189 0.445355832058823 no 1464 0.458693899709072 2203 4012779 SGTC_621 3584-0052 32.1 µM 0.102819230934949 0.445671637787741 no 1465 0.45905322103892 2223 2273927 SGTC_2488 5268135 45.7 µM 0.100830200875159 0.446365459840664 no 1466 0.459842626087784 2176 1270356 YLR208W SEC13 SGTC_2084 5306078 60.6385 µM 0.099503982980733 0.446828168287168 no 1467 0.460369062817537 2163 679340 SGTC_3123 9126162 49.47 µM 0.0973159728696427 0.44759170815728 no 1468 0.461237735845513 2225 25239884 SGTC_1207 2099-0101 141 µM 0.0965132270058583 0.447871887562748 no 1469 0.461556484667505 2230 5837381 SGTC_1708 st033234 31.827 µM 0.09383708952399 0.448806116992666 no 1470 0.462619284239883 2207 674664 SGTC_1417 3966-0327 90.4 µM 0.0933247632537954 0.448985000687673 no 1471 0.462822779849365 2162 651118 SGTC_695 3505-6186 243 µM 0.0921669693566709 0.44938929382 no 1472 0.463282690472972 2192 1819379 SGTC_2845 9003024 42.97 µM 0.0890048498082341 0.450493749281309 no 1473 0.464539027915015 2226 2990173 SGTC_998 3996-0085 177 µM 0.0883406843644034 0.450725775977398 no 1474 0.464802951945807 2210 715391 SGTC_522 1273-0010 11.6 µM 0.0882668252112278 0.450751579769899 no 1475 0.464832302828898 2169 5705015 SGTC_1415 3966-0071 78.1 µM 0.088255618150021 0.450755495141428 no 1476 0.464836756418797 2244 2893185 SGTC_1048 3161-0300 24.5 µM 0.0881349180135865 0.450797664026917 no 1477 0.46488472189575 2233 2165101 SGTC_2734 clemastine 41.6 µM 0.0876819981636376 0.450955905128335 no 1478 0.465064713946598 2264 26987 Clemastine is a selective histamine H1 antagonist. SGTC_1774 st048371 48.465 µM 0.0866494066237223 0.451316700983722 no 1479 0.465475096373003 2220 4242727 SGTC_2351 9026858 72.31 µM 0.0864159133649894 0.451398291007714 no 1480 0.465567898607681 2225 1409300 SGTC_1288 0973-0013 65.5 µM 0.0860514392602276 0.451525654037611 no 1481 0.465712763110698 2187 4315430 SGTC_1898 st060199 18.6 µM 0.0855790788247379 0.451690724643879 no 1482 0.465900515056973 2244 688866 SGTC_282 k297-0036 65.7 µM 0.0848681382702578 0.451939184958076 no 1483 0.46618311117461 2220 5061378 SGTC_2157 5649910 96.377 µM 0.0846046517698856 0.452031273306621 no 1484 0.466287850376645 2196 2858091 SGTC_3299 9121982 43.1275 µM 0.0838735852268576 0.452286794054122 no 1485 0.466578470738173 2146 17594604 YPL160W CDC60 SGTC_565 1418-0001 44.5 µM 0.0830320016144549 0.452580966945585 no 1486 0.466913046927015 2248 2862145 SGTC_2749 bexarotene 57.39 µM 0.0826817836768506 0.452703392197941 no 1487 0.467052284894963 2170 82146 An retinoic acid receptor inhibitor. SGTC_1448 4255-0083 152 µM 0.0823773254432759 0.452809824940874 no 1488 0.467173333215971 2248 5399660 SGTC_2376 9072922 81.32 µM 0.0801055838880554 0.453604088614999 no 1489 0.468076640860915 2213 17087968 SGTC_47 0149-0135 24.25 µM 0.0794792311238433 0.453823111641533 no 1490 0.468325725254698 2270 5239155 SGTC_3013 9080133 71.4286 µM 0.07849740070583 0.454166466326904 no 1491 0.468716198890434 2222 17050193 SGTC_1887 st057648 70.8 µM 0.0782131283174847 0.454265885273776 no 1492 0.468829259560979 2263 688672 SGTC_1244 0416-0015 52.5 µM 0.0773482043667811 0.454568393832599 no 1493 0.46917327209905 2207 96201 SGTC_2028 5153890 36.43 µM 0.0771935198686765 0.454622497770367 no 1494 0.469234798330968 2238 2830968 YPR165W RHO1 SGTC_70 0141-0289 43.283 µM 0.0770739999298556 0.454664302790279 no 1495 0.469282338255157 2152 352408 SGTC_662 k832-1615 104 µM 0.0769358417974061 0.454712627599659 no 1496 0.469337292201955 2206 5878478 SGTC_3306 9127676 59.7925 µM 0.0762406394935842 0.454955804903648 no 1497 0.469613825559366 2161 41905287 SGTC_2994 9053520 71.4286 µM 0.0756678449472531 0.455156177447954 no 1498 0.469841679320419 2249 4647384 SGTC_1917 st066507 28.5 µM 0.0740943254425921 0.455706677897072 no 1499 0.47046766524609 2167 3156428 SGTC_1506 4226-2149 212 µM 0.0740727007589884 0.455714243951401 no 1500 0.470476268605061 2169 991114 SGTC_827 3253-0474 693 µM 0.0739995593977595 0.455739834803807 no 1501 0.470505367925349 2267 5402065 SGTC_1089 terbinafine 2.25 µM 0.0724909188371446 0.456267721920258 no 1502 0.471105616087484 2256 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_2709 st078560 56 µM 0.0723211190094976 0.456327141282017 no 1503 0.471173179081588 2285 17250903 SGTC_2501 sodium tetradecyl sulfate 13.37 µM 0.0720269609970332 0.456430080572125 no 1504 0.471290225898289 2287 23665772 A membrane-active detergent. SGTC_3000 9075062 71.4286 µM 0.0711170357735267 0.456748523345919 no 1505 0.47165230495662 2184 17057871 SGTC_2804 7954240 19.48 µM 0.070541598027154 0.456949921269069 no 1506 0.47188129627829 2257 828705 SGTC_2282 7944268 200 µM 0.0696341938062231 0.457267526854365 no 1507 0.472242410132767 2236 2970414 SGTC_3200 9114385 49.47 µM 0.0685056922429783 0.457662558005673 no 1508 0.472691544484337 2193 17018030 YLR208W SEC13 SGTC_1182 1222-0449 220 µM 0.0681092425395492 0.45780134488462 no 1509 0.472849336480682 2230 658318 SGTC_1843 st055809 45.5 µM 0.0670396660155063 0.458175801829599 no 1510 0.473275062649381 2201 16413835 SGTC_345 1362-0200 395 µM 0.0662997976968397 0.458434850227074 no 1511 0.473569572143342 2191 1419823 SGTC_299 1273-0059 1.44 µM 0.0658870645936009 0.458579367200086 no 1512 0.473733869581726 2287 2848077 SGTC_3034 9090421 49.47 µM 0.0653390429349542 0.458771263419374 no 1513 0.473952028488449 2285 17173761 SGTC_2336 9001819 198.65 µM 0.0645465793006928 0.459048770847611 no 1514 0.474267509745697 2253 2989602 SGTC_2574 2',4'-dihydroxychalcone 14.64 µM 0.0629147517992274 0.459620272084741 no 1515 0.474917193939888 2262 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_2950 9072895 21.46 µM 0.0594797825212244 0.460823543812182 no 1516 0.476284984086835 2231 17332245 SGTC_1629 st005085 44.9 µM 0.0567421664116423 0.461782789788709 no 1517 0.477375292082986 2259 24207091 SGTC_1199 1638-0010 4.46 µM 0.0557676392320569 0.46212431283117 no 1518 0.477763457479964 2270 3111136 SGTC_3051 9093778 49.47 µM 0.0546259152192362 0.462524465510097 no 1519 0.478218246109941 2319 17217378 SGTC_505 gw-5074 63.9 µM 0.0525798243115678 0.46324167631607 no 1520 0.479033346298523 2281 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases. SGTC_2988 9073640 71.4286 µM 0.0519425151740888 0.463465095109751 no 1521 0.479287248884836 2285 9102229 SGTC_2433 5607874 27.82 µM 0.051696764336149 0.463551250033523 no 1522 0.479385157739896 2308 2252428 SGTC_3153 9100258 49.47 µM 0.0511100269337272 0.463756954370454 no 1523 0.479618923049663 2272 25236848 SGTC_1029 k015-0030 64.7 µM 0.0497624799941891 0.464229427607711 no 1524 0.480155833123494 2233 2208316 SGTC_3169 9102970 49.47 µM 0.049218360606277 0.4644202196002 no 1525 0.480372639675272 2331 17027839 SGTC_2954 9074818 52.69 µM 0.0486174397128021 0.464630938183672 no 1526 0.480612085759233 2289 16648742 SGTC_1046 2001-0062 216 µM 0.0481981157303578 0.464777983975934 no 1527 0.480779175936772 2297 739778 SGTC_160 3453-0671 289.699 µM 0.0462802148589435 0.465450601925153 no 1528 0.481543454332651 2309 5322268 SGTC_851 0394-0702 453 µM 0.0456290151672194 0.46567900363645 no 1529 0.481802971245992 2333 762646 SGTC_966 1300-0360 30.2 µM 0.0442166129988746 0.466174428177802 no 1530 0.4823658698731 2309 70588 SGTC_453 enantio-paf c16 10 µM 0.0440720391261304 0.466225142940013 no 1531 0.482423490333053 2316 13871343 A lipid and platelet activating factor SGTC_2636 apigenin dimethyl ether 100 µM 0.0424730014430117 0.466786102372835 no 1532 0.483060817024924 2292 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_325 2810-4341 181 µM 0.0423377180334671 0.466833564275107 no 1533 0.483114738793532 2330 774970 SGTC_3225 9130819 49.47 µM 0.0416701886290423 0.467067762598528 no 1534 0.483380809669179 2328 4547121 SGTC_640 3381-0960 37.1 µM 0.0414827271476998 0.46713353428659 no 1535 0.483455531369971 2314 1745025 SGTC_1553 gossypol 38.6 µM 0.041331043474027 0.467186753829849 no 1536 0.48351599254711 2317 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_3011 9081274 71.4286 µM 0.0409846807641402 0.467308280412792 no 1537 0.483654054290014 2293 6625322 SGTC_1486 3970-0793 4.53 µM 0.0405496137266592 0.467460934564053 no 1538 0.48382747675419 2342 2844330 SGTC_817 1391-0715 46 µM 0.0396413248728536 0.467779645823642 no 1539 0.484189540416134 2305 1353946 SGTC_1270 0831-1170 17.3 µM 0.0374272492782075 0.468556633289869 no 1540 0.485072173052617 2336 6764716 SGTC_1585 2',4'-dihydroxychalcone 10.4 µM 0.0362052086671418 0.468985536551837 no 1541 0.485559366399147 2341 5357218 A potent inhibitor of glutathione S-transferases. SGTC_445 e6 berbamine 66 µM 0.0359458420876311 0.46907657186627 no 1542 0.485662771383776 2302 6610268 A calcium/calmodulin antagonist. SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM 0.0347655838819441 0.469490852126871 no 1543 0.486133332057948 2318 115019 SGTC_2044 5102272 200 µM 0.0334154594743051 0.469964797288811 no 1544 0.486671640834745 2306 592666 SGTC_525 k781-2675 26.7 µM 0.0331505536573346 0.47005779434928 no 1545 0.486777264446217 2346 3651118 YDL195W SEC31 SGTC_3171 9103192 49.47 µM 0.0317771203685191 0.470539973889619 no 1546 0.487324896360539 2345 13018434 SGTC_785 1270-0111 65.3 µM 0.03072356187004 0.470909882365088 no 1547 0.487745000187648 2355 6741994 SGTC_2345 9052315 157.45 µM 0.0279693534524397 0.471877013393578 no 1548 0.48884329699103 2320 6469265 SGTC_1397 3532-0190 20.1 µM 0.0256925752001988 0.472676621893505 no 1549 0.489751273017814 2350 5322280 SGTC_2977 9011197 71.43 µM 0.0256096388319458 0.472705751389259 no 1550 0.489784348958251 2349 2704722 SGTC_2832 7992762 51.95 µM 0.0249578977894465 0.47293466553976 no 1551 0.490044272917442 2347 2985177 SGTC_2796 7949634 45.45 µM 0.0241469551516542 0.473219509307062 no 1552 0.490367694716255 2365 2971588 SGTC_2714 st079313 56.9 µM 0.0240785704752548 0.473243530066746 no 1553 0.490394968325061 2359 2939799 SGTC_2135 5326629 150.42 µM 0.0238315383121985 0.473330303243446 no 1554 0.490493491626683 2338 5020077 SGTC_1201 1889-3372 45.9 µM 0.022231087542886 0.473892512328103 no 1555 0.491131809720539 2310 5392199 SGTC_2979 9012552 45.46 µM 0.0202740056851824 0.474580069953954 no 1556 0.491912395991342 2378 17100905 SGTC_2770 toltrazuril 17.5 µM 0.019695904389029 0.474783181788019 no 1557 0.492142978985682 2364 68591 Kills coccidiodes. SGTC_159 3970-0959 50 µM 0.0196717514686825 0.47479166789011 no 1558 0.492152612740308 2359 6615653 SGTC_2444 5485484 36.41 µM 0.0190967441464525 0.474993699451044 no 1559 0.492381964376148 2346 6790631 SGTC_2824 7998404 51.95 µM 0.0177568726650264 0.475464494536279 no 1560 0.492916404978796 2360 837851 SGTC_3184 9108758 49.47 µM 0.0154111586036142 0.476288797957189 no 1561 0.493852080603055 2369 902885 SGTC_2468 5987765 72.9 µM 0.0150832099800263 0.476404049995839 no 1562 0.493982897967344 2313 26772094 SGTC_2478 5763493 32.33 µM 0.0150090575793424 0.476430109886269 no 1563 0.494012477146816 2372 1365576 YLR208W SEC13 SGTC_1186 1319-0216 26 µM 0.0147713420708435 0.476513652568632 no 1564 0.494107301400933 2382 4565136 SGTC_3324 9138759 60.749 µM 0.0143956776587817 0.476645678084535 no 1565 0.494257153881198 2339 45595710 SGTC_2639 lactacystin 53 µM 0.0129107626433285 0.477167569537622 no 1566 0.494849493997492 2379 3870 A proteasome inhibitor. SGTC_818 4072-2707 53.5 µM 0.0121956260731868 0.477418927015378 no 1567 0.49513476972736 2387 882871 SGTC_724 3910-0327 137 µM 0.0120627066341002 0.477465646770043 no 1568 0.495187793011012 2368 2885483 SGTC_371 0195-0006 7.36 µM 0.0117931333395249 0.477560399836941 no 1569 0.495295329545393 2355 3928593 SGTC_388 3',4'-dichloroisocoumarin 16.7 µM 0.0103906187900429 0.47805339392355 no 1570 0.49585481743433 2376 1609 A potent and irreversible inhibitor of serine proteases. SGTC_2653 dihydrofissinolide 100 µM 0.00979338177555505 0.478263337326615 no 1571 0.496093068394232 2377 6857746 SGTC_926 2268-1401 59.4 µM 0.00868371352406498 0.4786534288008 no 1572 0.496535743062546 2396 2931578 SGTC_79 0052-0007 94.094 µM 0.00867857428969935 0.478655235489077 no 1573 0.496537793243169 2389 2801472 SGTC_2064 5220758 200 µM 0.00833395238229745 0.478776387678236 no 1574 0.496675272518253 2367 788518 SGTC_168 3970-0862 530.542 µM 0.00766779096319464 0.47901058296572 no 1575 0.496941023962956 2374 3135186 SGTC_1363 1636-0063 10.4 µM 0.00726977892626752 0.479150511289419 no 1576 0.49709980336291 2394 6072185 SGTC_2765 myclobutanil 7.74 µM 0.00712523501963364 0.479201328948698 no 1577 0.497157466544976 2380 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11 SGTC_2054 5233173 129 µM 0.00691212952192117 0.479276251592813 no 1578 0.49724248124402 2381 6889 SGTC_2039 Aminomethylbenzodioxan 200 µM 0.00634626847319517 0.479475197946678 no 1579 0.497468222177886 2395 15053 SGTC_49 0717-0965 32.132 µM 0.00561996377558767 0.479730560828123 no 1580 0.49775797063764 2390 5889349 YGL099W LSG1 SGTC_3089 9117425 49.47 µM 0.00548271640412278 0.479778816836206 no 1581 0.497812723573271 2387 9401657 SGTC_771 0250-0039 27.3 µM 0.0053081682102027 0.479840188195925 no 1582 0.497882357214152 2395 3005115 SGTC_2092 5303694 80.6725 µM 0.00458669220025475 0.480093865102684 no 1583 0.498170180970011 2395 1963699 SGTC_2898 9056270 58.44 µM 0.00355011662023971 0.480458347700227 no 1584 0.498583711354823 2398 19154699 SGTC_1555 citronellol 128 µM 0.00321396084466285 0.480576550930704 no 1585 0.498717817338903 2398 8842 A terpine precursor. SGTC_2311 7694451 200 µM 0.00300208088231658 0.480651055648572 no 1586 0.498802344805835 2398 2163142 SGTC_1043 0916-0009 19.3 µM 0.00182973491029186 0.481063307370234 no 1587 0.499270041789666 2401 3101130 SGTC_246 cycloheximide 667 µM 0 0.481706768122493 no 1588 0.5 2386 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells. SGTC_2860 9025725 38.96 µM -0.00110939829020111 0.482096932247589 no 1589 0.49955741420702 2408 40546248 SGTC_1407 3909-7909 12.3 µM -0.00144351864316668 0.482214442363384 no 1590 0.499424119580691 2410 4411780 SGTC_1409 3909-8004 61.9 µM -0.00160926025978243 0.482272734257817 no 1591 0.499357998319304 2411 2119279 SGTC_1753 st043925 64 µM -0.00222834490988561 0.482490471791884 no 1592 0.499111019735838 2408 670181 SGTC_1272 0839-0021 27 µM -0.00230600935550609 0.48251778743272 no 1593 0.499080036184433 2418 5027250 SGTC_648 0375-0473 33.3 µM -0.00232748522086387 0.482525340800871 no 1594 0.499071468576726 2409 1713139 SGTC_3099 9120367 49.47 µM -0.00291603690747682 0.48273234525549 no 1595 0.49883667123508 2412 24824940 SGTC_970 1315-0089 19.5 µM -0.00442623805997702 0.483263531945115 no 1596 0.498234192260583 2420 6811083 YLR033W RSC58 SGTC_2287 7945887 168.79 µM -0.00526279712642313 0.483557789727295 no 1597 0.497900457404949 2416 1245853 SGTC_1215 3852-0577 11.2 µM -0.00592668556177226 0.483791317382425 no 1598 0.497635608388552 2428 2884876 SGTC_2138 5575593 77.673 µM -0.0065034982852068 0.483994220030442 no 1599 0.497405497852816 2420 762213 SGTC_2296 7971656 126.45 µM -0.00672139472525126 0.484070869498588 no 1600 0.497318571650726 2426 666570 SGTC_1581 himbacine 57.9 µM -0.00834245964332992 0.484641130072449 no 1601 0.496671878730117 2421 5281825 An alkaloid muscarinic receptor antagonist. SGTC_3284 9108171 64.8615 µM -0.00959103809548225 0.485080378293269 no 1602 0.4961737880518 2426 8687505 SGTC_1419 3993-2473 62.6 µM -0.0102888210360515 0.485325865313851 no 1603 0.495895426691608 2423 704026 SGTC_2925 9010536 32.5 µM -0.0112114986191302 0.485650481043691 no 1604 0.495527352874607 2445 2994177 SGTC_2802 7925815 54.55 µM -0.0114072321716633 0.485719345104038 no 1605 0.495449271478466 2431 1262923 SGTC_2441 5730946 39.09 µM -0.0126555092983559 0.486158530794553 no 1606 0.494951317029021 2439 1774275 SGTC_2326 6164455 177.58 µM -0.0127840504793666 0.486203756848581 no 1607 0.49490004066542 2443 2888790 SGTC_1175 0741-0056 27.6 µM -0.0131421926041449 0.486329766855891 no 1608 0.494757174634505 2432 765927 SGTC_2863 9028737 58.44 µM -0.013171465972706 0.486340066563195 no 1609 0.494745497260829 2425 6460917 SGTC_2484 5809818 12.04 µM -0.0136946486217908 0.486524147631108 no 1610 0.49453679641469 2448 2870548 SGTC_586 0957-0265 8.15 µM -0.0138757332223327 0.486587862660108 no 1611 0.494464560975133 2424 6752309 YPR165W | YPR107C RHO1 | YTH1 SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM -0.0144755824495862 0.486798923412952 no 1612 0.494225279803 2421 66535 A nucleotide analog. SGTC_602 3130-1533 38.1 µM -0.0148248445664019 0.486921815209664 no 1613 0.49408595933026 2445 720941 SGTC_53 0973-0023 39.979 µM -0.0154382128229973 0.487137638715106 no 1614 0.493841288814953 2437 674768 SGTC_2047 4141938 200 µM -0.0172707184573714 0.487782457543398 no 1615 0.493110322702349 2450 3807862 SGTC_2695 st077686 51.995 µM -0.0176277673526145 0.487908099045086 no 1616 0.492967902486047 2442 2876092 SGTC_2148 5546263 113.568 µM -0.01828094704176 0.488137948748754 no 1617 0.4927073634929 2448 792097 SGTC_937 3122-0005 46.7 µM -0.0189890236431632 0.48838712076858 no 1618 0.492424930848153 2438 759535 SGTC_307 1501-1223 22.3 µM -0.0201529807607474 0.488796726858921 no 1619 0.49196066808801 2455 2830329 SGTC_244 nsc-207895 1.295 µM -0.0202926126053746 0.488845865256697 no 1620 0.491904974430989 2414 42640 SGTC_2971 9092186 9.93 µM -0.0210685822107933 0.489118942870906 no 1621 0.49159547354669 2452 25236400 SGTC_2760 etidronate 98.04 µM -0.0211490278089872 0.489147253412987 no 1622 0.49156338754557 2461 3305 A chelator and antioxidant. SGTC_1109 tnp00067 928.257 nM -0.0212127196467801 0.489169667984017 no 1623 0.491537983877618 2451 676295 SGTC_1750 st081859 2.357 µM -0.0214543636636011 0.489254708186038 no 1624 0.491441603797483 2450 5291695 SGTC_3327 9140648 26.9345 µM -0.0218748933839098 0.489402703628902 no 1625 0.491273876079757 2447 8029710 SGTC_1824 st053723 68.6 µM -0.0243200265885308 0.490263238419722 no 1626 0.490298669473571 2459 675225 SGTC_1411 3909-8223 150 µM -0.0244663596117677 0.490314740018597 no 1627 0.490240308409448 2454 X1411 SGTC_230 MPP+ 141.667 µM -0.024508834137451 0.490329688868597 no 1628 0.490223368604988 2464 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death. SGTC_2449 5812982 45.77 µM -0.026495426206646 0.491028881990208 no 1629 0.489431090839155 2443 776185 SGTC_2358 9037157 4 µM -0.0279307108740056 0.491534056406284 no 1630 0.488858707128981 2480 2388925 SGTC_2914 7968218 45.32 µM -0.0285122743236042 0.491738752099729 no 1631 0.48862678925766 2464 2977111 SGTC_353 1988-1175 58.3 µM -0.0285889261393384 0.491765731772597 no 1632 0.488596222068261 2413 2788357 SGTC_1071 trifluoperazine 6.31 µM -0.0291680358496317 0.491969566255016 no 1633 0.488365287039197 2500 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. SGTC_225 nsc-122657 1.016 µM -0.0301828093472762 0.49232675028553 no 1634 0.487960629219594 2530 275685 SGTC_1862 st057513 3.81 µM -0.0302887178142849 0.492364028730432 no 1635 0.487918397162987 2466 5393163 SGTC_1010 4112-3296 15.2 µM -0.0308613898933871 0.492565603227975 no 1636 0.487690040823522 2463 704384 SGTC_647 0140-0236 81 µM -0.0312224515523122 0.492692694081222 no 1637 0.487546067445873 2491 990837 SGTC_2314 7727897 200 µM -0.0313556195757781 0.492739568362004 no 1638 0.487492967090041 2462 900724 SGTC_2363 9053361 176 µM -0.0320888772918468 0.492997672101954 no 1639 0.48720058673956 2479 6469797 YMR079W SEC14 SGTC_2389 9091542 195.52 µM -0.0333156444622763 0.493429495667805 no 1640 0.486711439104167 2500 3626624 YOL127W RPL25 SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM -0.0345709823424475 0.493871384125703 no 1641 0.486210920199549 2470 803109 SGTC_1323 1348-1351 11.2 µM -0.0354925875131939 0.49419580095571 no 1642 0.485843478480294 2483 6989654 SGTC_575 k072-0246 11.9 µM -0.0361004528382022 0.494409779453914 no 1643 0.485601130626001 2474 6796779 SGTC_1921 5740136 50 µM -0.0361014147748814 0.494410118072588 no 1644 0.485600747118778 2465 1774243 SGTC_2665 lovastatin 100 µM -0.0361991566789191 0.494444524967419 no 1645 0.485561779211498 2496 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1 SGTC_78 0336-0123 156.75 µM -0.036333122693398 0.494491683462785 no 1646 0.48550836963879 2482 6765896 SGTC_1225 1216-0074 20.6 µM -0.0364787991221332 0.4945429643262 no 1647 0.485450291653023 2508 4241466 SGTC_286 k060-0067 22.9 µM -0.0366801919210892 0.494613858556063 no 1648 0.485370001285304 2480 5985051 SGTC_1685 st024049 53.0905 µM -0.0368380873179062 0.494669440963161 no 1649 0.485307052679228 2513 1941139 SGTC_3212 9128307 49.47 µM -0.0374704592502461 0.494892049835529 no 1650 0.485054946851229 2509 27243542 SGTC_891 0929-0073 133 µM -0.037708928807525 0.494975996797851 no 1651 0.484959878451315 2585 5603632 SGTC_2131 toluylene red 5.2905 µM -0.0382061353768623 0.495151026060349 no 1652 0.484761664572923 2491 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain. SGTC_2425 5628681 7.85 µM -0.0383225392103171 0.49519200328399 no 1653 0.484715260146363 2501 5714958 SGTC_787 4152-0075 138 µM -0.0393673148046159 0.49555979410568 no 1654 0.484298769353144 2509 9566539 SGTC_2085 5307070 144.047 µM -0.0398778943111362 0.495739534053566 no 1655 0.484095237432968 2463 2840351 SGTC_1254 0550-0035 264 µM -0.0400824412142919 0.495811541202659 no 1656 0.48401370021627 2510 15121435 SGTC_624 k048-0052 28 µM -0.0406129864067493 0.495998310961041 no 1657 0.483802215521878 2510 6835531 SGTC_1007 4101-0031 70 µM -0.0409840644019625 0.496128943424319 no 1658 0.483654299976518 2471 1146276 SGTC_395 anisomycin 6.25 µM -0.0417761040824193 0.496407770529344 no 1659 0.483338592279154 2520 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_635 k038-0028 24.7 µM -0.0419957556918508 0.496485096293017 no 1660 0.483251040800584 2506 4035102 SGTC_1028 k015-0029 4.8 µM -0.0424062239785493 0.496629597173615 no 1661 0.483087433398424 2484 4588309 SGTC_1883 5-benzylidenerhodanine 20 µM -0.0427635149193678 0.496755377910609 no 1662 0.482945024122597 2486 1273210 SGTC_824 1304-0008 100 µM -0.0430465013718114 0.496855000717924 no 1663 0.482832232725546 2485 768245 SGTC_1731 st035964 63 µM -0.0434252611844285 0.496988339971624 no 1664 0.482681270588928 2540 6739575 SGTC_2163 5671233 125 µM -0.0459037078336956 0.497860864203123 no 1665 0.481693499435247 2488 701023 SGTC_2635 hydroquinidine 100 µM -0.0465961205233857 0.498104626491288 no 1666 0.481417562023816 2498 442912 An experimental heart treatment. SGTC_1021 4476-0760 85.3 µM -0.0467605996135952 0.498162531082518 no 1667 0.481352015807794 2495 746768 SGTC_2026 5148700 152 µM -0.0480130706650117 0.498603462622797 no 1668 0.480852912868544 2498 79838 SGTC_890 0929-0006 47.2 µM -0.0487170692916761 0.49885130562064 no 1669 0.480572386349766 2495 1378169 SGTC_694 1315-0438 43.2 µM -0.0488447504368959 0.498896255869129 no 1670 0.480521509511269 2527 6793154 SGTC_2365 9042475 200 µM -0.0492252360060486 0.499030206196524 no 1671 0.480369900108311 2522 6464479 SGTC_527 4476-4215 268 µM -0.0500739141464207 0.499328984561219 no 1672 0.480031743574268 2532 4418754 SGTC_3277 9138724 49.47 µM -0.0507396249543602 0.499563349284182 no 1673 0.479766500575821 2522 15943418 SGTC_3353 9151644 39.2805 µM -0.0512680184386929 0.499749371300263 no 1674 0.479555976082975 2558 4909158 SGTC_1153 4055-0057 267 µM -0.0513063804159524 0.499762876716096 no 1675 0.479540691982983 2498 882706 SGTC_1146 3579-1023 7 µM -0.0516865808696752 0.499896727108132 no 1676 0.479389214931145 2599 X1146 SGTC_98 0074-0023 107.663 µM -0.0519559195239875 0.499991548371834 no 1677 0.479281908533843 2553 3563821 SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM -0.052003933018865 0.499991548371834 no 1678 0.479262779780284 2483 756377 SGTC_1852 st056254 31.4 µM -0.0522039694871212 0.499921125094316 no 1679 0.479183085027585 2546 442583 SGTC_2245 6637752 200 µM -0.0522818014954804 0.499893724165558 no 1680 0.479152076893123 2522 681890 SGTC_308 4092-1169 104 µM -0.0526520802902484 0.49976336671516 no 1681 0.479004560207473 2494 2268590 YDL196W YDL196W SGTC_1977 st070720 65.3 µM -0.0527534520540583 0.499727678570319 no 1682 0.478964174850644 2578 682188 SGTC_329 k048-0121 21.3 µM -0.0529031609737089 0.499674973231129 no 1683 0.47890453291624 2545 6832902 SGTC_82 0054-0107 293.755 µM -0.0530240901525215 0.499632399864167 no 1684 0.478856356771866 2594 3104697 SGTC_2134 5324836 1.464 µM -0.0532645306972789 0.499547752287101 no 1685 0.478760570234232 2525 699272 SGTC_703 3875-0075 71.8 µM -0.0535663495684868 0.499441496376117 no 1686 0.478640333578519 2523 2850814 SGTC_2902 5787006 60.46 µM -0.0535838982260791 0.499435318338788 no 1687 0.478633342717158 2509 591003 SGTC_424 splitomicin 100 mM -0.0537111412690238 0.499390522194557 no 1688 0.478582653083795 2586 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_1592 4',5'-dihydroxyflavone 8.85 µM -0.0547899390646157 0.499010729837801 no 1689 0.478152907913512 2504 688669 SGTC_386 1509-0011 3.07 µM -0.0558404568926113 0.498640894344133 no 1690 0.477734452633471 2509 3107280 SGTC_3203 9113543 49.47 µM -0.0563554155020447 0.498459603233195 no 1691 0.477529336875262 2617 17018012 SGTC_3273 9137859 49.47 µM -0.0576214373093087 0.498013901851673 no 1692 0.477025086768913 2495 2377234 SGTC_2463 5473429 200 µM -0.05836023352863 0.497753810683586 no 1693 0.476730844901729 2590 5399405 SGTC_1060 3448-7350 82 µM -0.0589479805580064 0.497546896642061 no 1694 0.47649677075454 2527 570178 SGTC_183 3914-0051 30.55 µM -0.0590887585376122 0.497497336401146 no 1695 0.476440706192589 2541 1596232 SGTC_42 0133-0086 60.653 µM -0.0600096733796714 0.497173133549751 no 1696 0.476073965167034 2524 162923 Model of phenazepam hydroxylation. SGTC_2464 5717415 7.67 µM -0.0617203099141596 0.496570918769114 no 1697 0.475392782915095 2524 5285744 SGTC_331 k048-0133 24.5 µM -0.0637508573801444 0.495856092368672 no 1698 0.474584304369746 2512 6813582 SGTC_1158 4092-0494 91.8 µM -0.0640765113804617 0.495741451520213 no 1699 0.474454652303121 2623 1148199 SGTC_1801 st050089 28.441 µM -0.0641130929035451 0.495728573650627 no 1700 0.474440088333068 2513 5008493 YIL048W | YNL267W NEO1 | PIK1 SGTC_901 1112-0062 60.1 µM -0.0643622733942213 0.495640854243827 no 1701 0.474340884592563 2500 1908457 SGTC_2591 skatole 100 µM -0.0653404878638404 0.495296493916837 no 1702 0.473951453274412 2578 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite. SGTC_391 gliotoxin 8.33 µM -0.0660193472698396 0.495057517440692 no 1703 0.473681211081523 2612 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion SGTC_1740 st038286 13.222 µM -0.0666466315852933 0.494836698336039 no 1704 0.473431510803863 2595 716786 SGTC_962 1254-0300 21.5 µM -0.0669068020817421 0.494745112549605 no 1705 0.473327948948484 2514 7340576 SGTC_750 4073-0104 132 µM -0.0678074925463566 0.494428051694753 no 1706 0.472969439651543 2536 22330957 SGTC_1058 3448-5425 97.3 µM -0.0680238855210198 0.494351877605318 no 1707 0.472883310211946 2516 7279705 SGTC_2165 5727197 32.143 µM -0.0683574563265108 0.494234455286505 no 1708 0.472750543753722 2858 1361712 SGTC_3194 9111903 49.47 µM -0.0686908204335043 0.494117106227991 no 1709 0.472617862589268 2619 17087251 SGTC_2434 5670830 169.91 µM -0.0688828288267758 0.494049516685815 no 1710 0.472541443330871 2596 1549830 SGTC_431 k089-0097 107 µM -0.068909786508255 0.49404002723225 no 1711 0.472530714266021 2517 5499420 SGTC_1485 3909-9022 254 µM -0.0691054554189844 0.493971149338952 no 1712 0.472452839307909 2522 714516 SGTC_485 niflumic acid 177 µM -0.0701321084095085 0.493609757694321 no 1713 0.472044255398422 2630 4488 A COX2 inhibitor. SGTC_1055 3448-0672 86 µM -0.0701695105209117 0.493596591891592 no 1714 0.472029370784509 2629 748378 SGTC_684 1140-0066 328 µM -0.0703410918262927 0.493536194171196 no 1715 0.471961088469635 2554 6813534 SGTC_2927 9011802 47.9 µM -0.070892034755471 0.49334225973384 no 1716 0.471741841385545 2592 43912568 SGTC_1181 1222-0449 220 µM -0.0715397209424225 0.493114273241905 no 1717 0.471484106392464 2605 658318 SGTC_1273 0849-0096 14.1 µM -0.0722553242641195 0.492862382436873 no 1718 0.471199358895457 2568 5286025 SGTC_1527 coumarin 137 µM -0.0726103986658357 0.492737398073801 no 1719 0.471058075813425 2758 323 A hepatotoxic, DNA x-linker. SGTC_712 r015-0009 80.6 µM -0.0729233786291753 0.492627231327324 no 1720 0.470933545007021 2585 6813872 YLR060W FRS1 SGTC_883 0850-0245 24.6 µM -0.0733060639744676 0.492492529541525 no 1721 0.470781283165825 2710 6823229 YPR165W RHO1 SGTC_2951 9072950 58.06 µM -0.0733693113193621 0.492470267129286 no 1722 0.470756118888882 2531 16488155 SGTC_2800 7887935 81.82 µM -0.0734523933004273 0.4924410231656 no 1723 0.470723063165198 2607 2961002 SGTC_85 0868-0259 160.055 µM -0.0735951386701874 0.492390778425802 no 1724 0.470666269714988 2614 83173 SGTC_882 0843-0131 351 µM -0.073891648256622 0.492286410824696 no 1725 0.470548300704261 2529 5425421 SGTC_1974 st069448 26.9 µM -0.0740351368548819 0.492235904853272 no 1726 0.470491213399892 2556 6323587 YNR016C ACC1 SGTC_1143 3454-2408 5.08 µM -0.0741137139581158 0.492208246869169 no 1727 0.470459951556097 2509 X1143 SGTC_811 0416-0114 265 µM -0.0744499774591469 0.492089887489609 no 1728 0.470326171423923 2616 6612453 SGTC_573 3702-0553 84.7 µM -0.0744795729824137 0.492079470371488 no 1729 0.470314397207707 2545 1222756 SGTC_2779 methotrexate 400 µM -0.0748445928970365 0.491950990049585 no 1730 0.470169180645501 2516 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2 SGTC_619 1652-1634 108 µM -0.0760311314620658 0.49153335605296 no 1731 0.469697165274151 2581 5400454 SGTC_2261 9010538 184.68 µM -0.0767136832878559 0.491293117850313 no 1732 0.469425659465287 2649 6457250 SGTC_923 1900-2434 73.3 µM -0.0784232818072563 0.490691403420307 no 1733 0.468745677178519 2533 5910570 SGTC_1908 st060353 56.5 µM -0.0790862975691975 0.490458052414484 no 1734 0.468481991164703 2606 4227716 SGTC_788 1182-0090 188 µM -0.0794343263594561 0.490335563614577 no 1735 0.46834358320273 2759 5715185 SGTC_3 0833-0587 95.581 µM -0.0801848204906174 0.490071430177191 no 1736 0.468045131389344 2509 5382644 SGTC_435 c-PAF 6.7 µM -0.0814682681504806 0.489619736009155 no 1737 0.467534779659827 2548 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase SGTC_2171 5739187 198.077 µM -0.0816110304467445 0.489569493325876 no 1738 0.467478014764648 2539 2262761 SGTC_1913 st060213 96.1 µM -0.0836153489217076 0.488864126473625 no 1739 0.466681131499522 2604 688959 SGTC_1554 st069299 38.7 µM -0.0841201282522036 0.488686488148503 no 1740 0.466480460665911 2615 24207999 SGTC_1220 1838-0075 193 µM -0.0843810739829803 0.488594658874415 no 1741 0.46637672719398 2585 5529645 SGTC_2937 9044753 11.33 µM -0.0848440086333475 0.488431749277352 no 1742 0.466192702911838 2562 6465530 YGL099W LSG1 SGTC_839 0122-0028 230 µM -0.0868152978041594 0.487738062235089 no 1743 0.465409163823049 2563 759448 SGTC_1604 st002052 72.4 µM -0.0873957521792252 0.487533810147797 no 1744 0.465178472865489 2685 6254834 YHR062C RPP1 SGTC_3146 9095609 49.47 µM -0.0879030926487403 0.487355288284654 no 1745 0.464976849271859 2625 17173999 SGTC_1086 cerivastatin 2.18 µM -0.0891618762296317 0.486912361268909 no 1746 0.464476631512398 2566 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7 SGTC_2411 st077133 39.94 µM -0.0895328871298009 0.486781817061987 no 1747 0.464329209187459 2856 1403142 YNL221C POP1 SGTC_179 1273-0063 6.77 µM -0.0908036815113394 0.486334685103577 no 1748 0.463824292358041 2578 3108139 SGTC_2777 climbazole 1.536 µM -0.092088749734269 0.485882548332387 no 1749 0.463313763440728 2569 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2 SGTC_770 0389-1121 67.2 µM -0.0921022548146538 0.485877796817403 no 1750 0.463308398493093 2760 6753108 SGTC_2211 7117706 200 µM -0.0921157564645361 0.485873046511384 no 1751 0.46330303491491 2561 822771 SGTC_52 0329-0193 875 nM -0.0923389637408923 0.485794515446761 no 1752 0.46321436600213 2775 3739292 SGTC_716 1683-5115 658 µM -0.0930293126232202 0.485551633349575 no 1753 0.462940137044639 2556 723597 SGTC_1709 st033179 39.1045 µM -0.093336917640069 0.485443411890088 no 1754 0.462817952023385 2554 573381 SGTC_3172 9105863 49.47 µM -0.0956596319607058 0.484626270750417 no 1755 0.461895451421267 2573 2348785 SGTC_2112 5488546 200 µM -0.096687382438385 0.484264723999884 no 1756 0.461487330118056 2569 600757 SGTC_1293 1000-1278 195 µM -0.0978105497499074 0.483869625884709 no 1757 0.461041365033198 2648 678847 SGTC_2917 7979103 53.79 µM -0.0987754485351499 0.483530214740196 no 1758 0.460658281188219 2672 2980565 SGTC_1319 1306-0155 43.7 µM -0.0990676278089064 0.483427440601948 no 1759 0.460542287440229 2583 3122360 SGTC_1994 st072947 40.9 µM -0.0992920195329931 0.483348511499749 no 1760 0.460453207298022 2711 5286565 YDL195W SEC31 SGTC_3251 9135047 49.47 µM -0.100093548472021 0.483066581498553 no 1761 0.460135028592436 2693 17682963 SGTC_919 tnp00227 403.569 nM -0.100527729119586 0.482913866209028 no 1762 0.459962684841725 2636 1269246 A methoxyflavone. YNL221C POP1 SGTC_2472 5377652 49.4 µM -0.101673019310262 0.482511042922089 no 1763 0.459508109305836 2631 1610903 SGTC_1732 st034308 51.822 µM -0.102981940556913 0.482050688945153 no 1764 0.458988652043262 2555 830119 SGTC_1460 k062-0059 9.15 µM -0.104534518267297 0.48150467088144 no 1765 0.458372588353964 2531 1373085 SGTC_3259 9138485 49.47 µM -0.104929954486952 0.481365607455583 no 1766 0.458215694961032 2620 17646153 SGTC_3017 9080681 49.47 µM -0.10577572075787 0.481068183671458 no 1767 0.457880150364537 2657 16451914 SGTC_519 k048-0011 62.8 µM -0.106000856757575 0.480989013684403 no 1768 0.457790836211624 2724 6836379 SGTC_748 act1.228 77.9 µM -0.106062623653468 0.480967293235989 no 1769 0.457766332915174 2590 4421505 YNR035C ARC35 SGTC_3070 9117005 49.47 µM -0.106070287796759 0.480964598129116 no 1770 0.457763292514956 2580 8779016 SGTC_342 k048-0088 23.3 µM -0.106083835641706 0.480959834012327 no 1771 0.457757918029795 2578 6820570 SGTC_1787 fluconazole 80 µM -0.106615335815419 0.480772933457767 no 1772 0.457547075855898 2614 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C SGTC_1247 0448-0043 5.84 µM -0.111033024267231 0.479219633053231 no 1773 0.455795079527644 2697 3089013 YGL099W LSG1 SGTC_2246 7293507 91.5585 µM -0.11181899305018 0.47894331149553 no 1774 0.455483463845989 2786 887656 SGTC_432 NS 1619 61.3 µM -0.112576115337629 0.478677141014042 no 1775 0.455183310925358 2757 4552 A K+/calcium channel activator. SGTC_1492 4158-0558 28.5 µM -0.113300627645206 0.478422443651697 no 1776 0.454896109828409 2716 3967268 SGTC_683 panaxydol 45 µM -0.113486484322074 0.478357108420043 no 1777 0.45482243890181 2674 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis. SGTC_2576 guaiol 23.12 µM -0.114316092484183 0.478065478764228 no 1778 0.454493613083739 2763 227829 SGTC_3108 9121785 49.47 µM -0.114338555844374 0.478057582449555 no 1779 0.45448470987589 2549 17140271 SGTC_3114 9122766 49.47 µM -0.11452719450114 0.477991272576995 no 1780 0.454409945064374 2663 17176985 SGTC_490 phenamil 164 µM -0.114954929197532 0.477840918416343 no 1781 0.454240423212389 2716 4755 Irreversibly blocks amiloride-sensitive Na+ channels. SGTC_1847 st056231 15 µM -0.117312291591469 0.477012332857632 no 1782 0.453306292503275 2600 5393180 SGTC_868 0527-0199 213 µM -0.117382960631755 0.476987495025339 no 1783 0.453278293082921 2675 2849450 SGTC_2873 9040596 71.43 µM -0.118128267092855 0.476725549895961 no 1784 0.452983013176251 2726 6463863 SGTC_1119 parthenolide 318.541 nM -0.118352510769974 0.476646739260197 no 1785 0.452894176074539 2807 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs. SGTC_2588 indole-3-carbinol 100 µM -0.118644191421219 0.476544229208374 no 1786 0.452778626451158 2713 3712 Induces cell cycle arrest. SGTC_1504 k297-0033 30 µM -0.11916243947065 0.476362096742469 no 1787 0.452573331764238 2585 4388117 SGTC_2837 9008476 45.46 µM -0.11926668707367 0.476325460686662 no 1788 0.452532037472407 2807 2992805 SGTC_1864 st057645 30.4 µM -0.12017910841787 0.476004814222056 no 1789 0.452170633442077 2634 688666 SGTC_2502 avocadyne acetate 18.59 µM -0.1202082051476 0.475994589196823 no 1790 0.452159109071235 2586 3952079 SGTC_964 1287-0107 19.4 µM -0.121926609854002 0.475390744392631 no 1791 0.451478570616436 2732 51516812 YPR165W RHO1 SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM -0.12194967219286 0.475382640703038 no 1792 0.451469438221764 2737 5393153 SGTC_1140 3229-1848 2.98 µM -0.122618356259956 0.475147681633512 no 1793 0.451204658971631 2710 2849525 SGTC_1070 indatraline 8.81 µM -0.123026773807481 0.475004178038439 no 1794 0.451042948290345 2641 10314472 A monamine transport inhibitor. YGL099W LSG1 SGTC_219 mitoxanthrone 164.414 µM -0.123087801567587 0.474982735302981 no 1795 0.45101878538155 2701 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA.  YMR168C CEP3 SGTC_2618 avocadyne 43.43 µM -0.123118048522345 0.474972107749072 no 1796 0.451006809678972 2657 3015189 SGTC_1564 D-Arginine 115 µM -0.123954101236738 0.47467835978815 no 1797 0.450675808305839 2670 71070 D-isomer of arginine; arginine decarboxylase inhibitor. SGTC_1425 4048-4433 7.33 µM -0.124031990242592 0.474650994106178 no 1798 0.450644973036593 2653 23734946 SGTC_1321 1326-2144 215 µM -0.124336605720585 0.474543971033348 no 1799 0.450524382495833 2747 3513030 SGTC_2555 cholic acid 100 µM -0.12577370317511 0.474039088614835 no 1800 0.449955529134434 2783 6708657 Influences liver metabolism. SGTC_1258 0671-0043 57.1 µM -0.127547743769357 0.473415888608491 no 1801 0.44925344382937 2690 4298767 SGTC_2206 7254556 146.969 µM -0.1276028120157 0.473396544801698 no 1802 0.449231652830264 2685 4398905 SGTC_2819 7996655 46.38 µM -0.128613057786546 0.473041687243483 no 1803 0.448831916753527 2720 6456960 SGTC_2126 5251174 33.877 µM -0.12928241157008 0.472806582707634 no 1804 0.448567094083028 2699 790722 SGTC_1825 st052143 62.6 µM -0.13187138693409 0.471897318159902 no 1805 0.44754301043168 2753 674173 SGTC_1891 st059073 26.2 µM -0.132325334626848 0.471737903810885 no 1806 0.447363484718405 2788 688754 SGTC_2450 5739737 12.93 µM -0.133665793088452 0.471267196993782 no 1807 0.446833427768617 2709 2262825 SGTC_2745 rifampicin 24.3 µM -0.134115678585485 0.471109227044052 no 1808 0.446655550965511 2729 25141428 Inhibits bacterial DNA-dependent RNA polymerase. SGTC_173 1273-0061 2.693 µM -0.134634211205695 0.470927158417958 no 1809 0.446450545614512 2748 2847414 YPL266W DIM1 SGTC_1353 1498-1206 8.11 µM -0.13737918345648 0.469963438204792 no 1810 0.445365542113532 2645 6756808 SGTC_2077 5212015 200 µM -0.137926308861466 0.469771371203366 no 1811 0.44514932882854 2615 780900 SGTC_2053 5265679 138 µM -0.138497089748828 0.469571007500765 no 1812 0.444923784748291 2653 764595 SGTC_3068 9116768 49.47 µM -0.139006776301689 0.469392096519275 no 1813 0.444722397162008 2737 41904888 SGTC_2347 9049783 174.81 µM -0.141288346333406 0.468591292451155 no 1814 0.443821077770789 2768 6467988 YPL169C MEX67 SGTC_2390 9097792 176.6 µM -0.141842912641431 0.468396665315255 no 1815 0.44360204367159 2675 4497149 SGTC_3220 9131269 49.47 µM -0.142040051127474 0.468327480637909 no 1816 0.443524185081817 2620 17722206 SGTC_2529 gangaleoidin 93.61 µM -0.142129407115724 0.468296121955709 no 1817 0.4434888952211 2675 4565183 SGTC_1126 isoteolin 1.0172 µM -0.143511326168104 0.467811175030381 no 1818 0.442943183425179 2675 133323 SGTC_2856 9022925 19.48 µM -0.144053551839439 0.4676209086792 no 1819 0.442729091165422 2806 4944862 SGTC_2666 tannic acid 100 µM -0.145484641108694 0.467118776774253 no 1820 0.442164120676581 2715 16134267 A thiamine antagonist. SGTC_3139 9095020 49.47 µM -0.146800748628677 0.466657035133503 no 1821 0.441644646883315 2624 25236292 SGTC_692 k241-0027 77.8 µM -0.147615012957662 0.46637138200689 no 1822 0.441323303140055 2806 3600480 SGTC_853 0419-0306 21 µM -0.148763965926018 0.465968345823609 no 1823 0.440869942603692 2665 762713 SGTC_2667 digitoxin 100 µM -0.148944022407885 0.465905187751095 no 1824 0.440798901879022 2728 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_2564 betulinic acid 100 µM -0.14911027245413 0.465846873298381 no 1825 0.440733310132158 2871 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14 SGTC_2911 7942208 15.64 µM -0.150354321622757 0.465410529583168 no 1826 0.440242538790278 2762 1243384 SGTC_2316 5844804 197.44 µM -0.150528549621289 0.465349423335032 no 1827 0.440173814003559 2787 776813 SGTC_730 1436-0052 41.2 µM -0.152308986011067 0.464725025507813 no 1828 0.439471618898985 2663 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2 SGTC_1122 capsaicin 818.572 nM -0.153763704354095 0.464214921179889 no 1829 0.438898026578223 2812 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_1911 st060208 74.3 µM -0.156046161839908 0.463414684797442 no 1830 0.437998317493447 2792 688783 SGTC_1023 4482-3888 16 µM -0.157620261264072 0.462862886898535 no 1831 0.437378018486216 2885 3303168 SGTC_2851 9015922 71.43 µM -0.158083097231832 0.462700654076297 no 1832 0.437195659792557 2846 2996893 SGTC_1187 1391-0724 117 µM -0.158231358223317 0.462648687085598 no 1833 0.437137247357966 2723 6997986 SGTC_332 4112-0506 40.9 µM -0.160234167055203 0.461946744981924 no 1834 0.436348307842819 2696 2790355 SGTC_1462 k081-0014 26.5 µM -0.160984290584563 0.461683872949967 no 1835 0.436052886776962 2714 3270634 SGTC_886 0866-0150 153 µM -0.161401530652979 0.461537663276961 no 1836 0.435888580596331 2878 271463 SGTC_38 0929-0051 58.268 µM -0.161795001402829 0.461399787633903 no 1837 0.435733644741336 2800 1379719 SGTC_2593 nobiletin 86.24 µM -0.161923215936802 0.461354861124577 no 1838 0.435683160199449 2780 72344 An anti-infammatory. SGTC_2521 angolensin 13.4 µM -0.162761913441383 0.461060992815564 no 1839 0.435352948493234 2833 821428 A flavenoid. SGTC_3117 9124945 49.47 µM -0.164152629516125 0.460573751570999 no 1840 0.434805495662691 2667 17592065 SGTC_234 nsc-17383 10.7 µM -0.166816124788565 0.459640754443335 no 1841 0.43375736536064 2747 408974 SGTC_218 alverine citrate 93.75 µM -0.167342672870741 0.459456335789505 no 1842 0.433550214702759 2802 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_2175 5807670 165.306 µM -0.16777181995747 0.459306037394675 no 1843 0.433381396322572 2749 241186 SGTC_1767 st044992 70.3 µM -0.168418479393566 0.459079571548252 no 1844 0.433127035647036 2748 9600693 SGTC_1734 st037168 69.4 µM -0.169655752731748 0.458646304567272 no 1845 0.432640436854882 2798 708907 SGTC_1791 st048313 56.1 µM -0.171152598431913 0.458122206538848 no 1846 0.432051889205446 2826 1204976 SGTC_611 3453-1652 23.7 µM -0.171431683155853 0.458024497241594 no 1847 0.431942171980824 2772 1560575 SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM -0.173018285435568 0.457469066292731 no 1848 0.431318527340099 2706 442882 SGTC_2969 9091408 28.7 µM -0.173545546351007 0.457284503377977 no 1849 0.431111315082671 2729 4286311 SGTC_537 1334-0398 209 µM -0.173985820445267 0.457130396469432 no 1850 0.430938302957963 2771 5846986 SGTC_3150 9097574 49.47 µM -0.174270222648398 0.457030852034038 no 1851 0.430826550008776 2808 17217476 SGTC_706 4262-0057 46.9 µM -0.174399524206868 0.456985595713765 no 1852 0.430775744109216 2718 883298 SGTC_2623 humulene 100 µM -0.17453708656402 0.456937448676925 no 1853 0.430721693587739 2787 6187145 An anti-inflammatory. SGTC_726 3448-4391 34.2 µM -0.174631295492818 0.456904475771415 no 1854 0.430684678092723 2876 1356692 SGTC_1176 0848-0131 83.3 µM -0.175712811682905 0.456525968935788 no 1855 0.430259784821571 2816 6769040 SGTC_615 k087-0205 167 µM -0.176594845013835 0.456217305890565 no 1856 0.42991332176461 2734 9642773 SGTC_2692 st077426 47.7 µM -0.176899799338845 0.456110594823583 no 1857 0.429793548120018 2838 25238571 SGTC_1799 st045822 46.1415 µM -0.177191647941957 0.456008472737507 no 1858 0.429678927919958 2793 3674992 SGTC_1923 st058458 19.1 µM -0.177201890068755 0.456004888920589 no 1859 0.42967490554943 2974 3534982 SGTC_1301 naphtanilide LB 4.81 µM -0.179731372132126 0.455119909579907 no 1860 0.428681731542546 2836 67238 An a1-adrenergic receptor antagonist or alpha blocker. SGTC_935 2996-0153 430 µM -0.180659193618053 0.454795352134215 no 1861 0.428317545219896 2780 23738523 SGTC_1945 st075991 56.6 µM -0.181107048555508 0.454638700611634 no 1862 0.428141776069848 2777 1084980 SGTC_842 0271-0008 11.1 µM -0.182008907121835 0.454323268297318 no 1863 0.427787867893 2841 1221709 SGTC_452 diindolylmethane 8 µM -0.183174615180236 0.453915595199298 no 1864 0.427330505758808 2839 3071 Inhibits expression of several cancer promoting factors. SGTC_80 0159-0065 512.242 µM -0.183247127397157 0.453890237722088 no 1865 0.427302059023222 2690 1548079 SGTC_478 N-arachidonylglycine 10 µM -0.183772602914689 0.453706484882826 no 1866 0.427095924883473 2718 5283389 SGTC_2055 5235184 200 µM -0.184505465905438 0.453450227548694 no 1867 0.426808469798505 2885 2836034 SGTC_2111 5486399 200 µM -0.185027231452946 0.453267795636411 no 1868 0.426603838360364 2729 689674 SGTC_872 0588-0139 234 µM -0.185521259743377 0.453095070963614 no 1869 0.426410103414284 2733 2047100 SGTC_985 1493-0307 8.71 µM -0.185570055972326 0.453078011059926 no 1870 0.426390968762796 2828 3278274 SGTC_1690 st023502 41.2 µM -0.186137031585974 0.452879794120552 no 1871 0.426168651165635 2832 24207482 SGTC_2346 9031566 143.75 µM -0.187885089614548 0.452268740166447 no 1872 0.425483365673466 2853 4771086 SGTC_2323 6148992 148.28 µM -0.188318765730631 0.452117161096135 no 1873 0.425313387800284 2796 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42 SGTC_489 paxilline 115 µM -0.189271447591469 0.451784202963318 no 1874 0.424940036181627 2802 105008 A toxic potassium channel blocker. SGTC_281 1672-3440 14.9 µM -0.1894541407136 0.451720356386264 no 1875 0.424868447273429 2842 6833000 SGTC_221 trifluoperazine 10.304 µM -0.18952290763079 0.451696324429588 no 1876 0.424841501369697 2749 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1 SGTC_671 0560-0003 407 µM -0.190401522971095 0.451389290563931 no 1877 0.424497252172524 2811 3238678 SGTC_1562 morin hydrate 59.1 µM -0.191820128802073 0.450893617409712 no 1878 0.423941551621842 2922 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase. SGTC_2976 9009005 19.48 µM -0.192258020468296 0.450740629701594 no 1879 0.423770049867081 2965 2993148 SGTC_39 0986-0283 58.349 µM -0.192949726692163 0.450498980852844 no 1880 0.423499170209297 2880 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2 SGTC_1779 st039427 55 µM -0.193817312953454 0.450195913938728 no 1881 0.423159465143621 2763 1124498 SGTC_2139 5578692 56.4705 µM -0.193898898717716 0.450167415732625 no 1882 0.423127523015377 2808 650991 YMR113W FOL3 SGTC_2964 9083345 53.42 µM -0.194555671714175 0.449938011893537 no 1883 0.422870404333925 2793 17741579 SGTC_2447 5741742 33.78 µM -0.195219461672873 0.449706174101137 no 1884 0.422610571977654 2831 1776504 SGTC_3309 9129340 25.759 µM -0.195387205622412 0.449647589928592 no 1885 0.422544916011391 2794 17158987 SGTC_2273 7815444 169.05 µM -0.197066133216726 0.449061289159609 no 1886 0.421887892743755 2961 2824616 SGTC_1477 0139-0234 16 µM -0.198857460431545 0.448435859808828 no 1887 0.421187123264969 2744 620880 SGTC_1768 st044301 37.178 µM -0.199140367736065 0.448337096381497 no 1888 0.421076472334253 2802 3931349 SGTC_137 0438-0332 85.389 µM -0.200327688154965 0.447922635766611 no 1889 0.420612154703195 2746 2063393 YER012W | YPR107C PRE1 | YTH1 SGTC_676 falcarinol 140 µM -0.201193768463898 0.447620346991606 no 1890 0.420273531958047 2903 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer. SGTC_2405 ticlatone 3.52 µM -0.202537796110504 0.447151300131793 no 1891 0.419748156802796 2663 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W SGTC_715 0868-0130 184 µM -0.202579262937953 0.447136829960665 no 1892 0.41973194985127 2909 2876258 SGTC_2835 9006588 71.43 µM -0.205093216066757 0.446259698675598 no 1893 0.418749648287092 3006 2345538 SGTC_487 nimodipine 119 µM -0.205624451925579 0.446074381231683 no 1894 0.418542137892802 2852 4497 L-type voltage-gated calcium channels inhibitor SGTC_2121 5257820 149.641 µM -0.20591360228282 0.445973518355506 no 1895 0.418429200023615 2911 791256 SGTC_2742 clothiapine 36.27 µM -0.206184957960874 0.445878865888274 no 1896 0.4183232186099 2813 16351 An atypical antipsychotic. YIL048W NEO1 SGTC_2482 5981709 142.65 µM -0.207440130973909 0.445441085070815 no 1897 0.417833072078173 2840 877755 SGTC_1470 k295-0292 231 µM -0.207468242962298 0.445431280895871 no 1898 0.417822095772 2880 5045612 SGTC_441 propafenone 146 µM -0.209002774317994 0.444896157381516 no 1899 0.417223036426754 2751 4932 Slows the influx of sodium ions into the cardiac muscle. SGTC_84 0443-0269 128.823 µM -0.209230514259427 0.444816748183736 no 1900 0.417134146311265 2776 6150058 SGTC_390 dec-rvkr-cmk 16.7 µM -0.209859675190358 0.444597381563112 no 1901 0.416888597941419 2824 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1 SGTC_1805 st050013 60.3 µM -0.210860600081301 0.444248428725445 no 1902 0.416498024713327 2833 4037144 SGTC_2487 5918373 44.05 µM -0.210874498448661 0.444243583635736 no 1903 0.416492601978427 2771 2876279 SGTC_2986 9022445 71.43 µM -0.211302544260944 0.444094367288849 no 1904 0.416325598856657 2990 6459286 SGTC_1447 4239-0816 81.9 µM -0.21300755451002 0.443500081255526 no 1905 0.41566053512741 2784 1341554 SGTC_1957 st077035 62.4 µM -0.213049903744297 0.443485321924469 no 1906 0.41564401926649 2826 705593 SGTC_2010 4012422 159 µM -0.213275455126678 0.443406715271324 no 1907 0.415556058551556 2865 952393 SGTC_1154 4088-0362 150 µM -0.213348320804495 0.443381321413441 no 1908 0.415527643238212 2757 6618304 SGTC_1967 st070177 51.4 µM -0.213547597300979 0.443311874279595 no 1909 0.415449933953894 2956 5729214 SGTC_2166 5933061 31.504 µM -0.214682840464468 0.442916279445465 no 1910 0.415007300991186 3293 2877375 SGTC_2443 5493264 126.67 µM -0.217811028653347 0.441826504520876 no 1911 0.413788175619321 2968 5340055 SGTC_3094 9117742 49.47 µM -0.2178167849323 0.441824499594468 no 1912 0.413785933029723 2751 17149698 SGTC_2008 4012253 172 µM -0.218020144282689 0.44175366997907 no 1913 0.413706708034159 2776 603940 SGTC_2103 5378138 10 µM -0.218641867630183 0.441537136662151 no 1914 0.41346451805592 2786 244142 SGTC_690 glyoxal 20.3 µM -0.21921992937054 0.441335825448275 no 1915 0.41323936582291 2809 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins. SGTC_1384 3089-0840 101 µM -0.219222221045264 0.44133502739787 no 1916 0.413238473283494 2905 1069836 SGTC_547 1120-0019 610 nM -0.219579202787837 0.4412107153603 no 1917 0.413099444948009 2768 3676939 SGTC_1624 st003710 6.25 µM -0.220424001655918 0.440916553468351 no 1918 0.412770477218586 2983 24207033 SGTC_1587 estradiol valerate 56.1 µM -0.221483744136093 0.440547593576708 no 1919 0.412357896309545 2954 13791 A steroid. SGTC_1219 1469-0211 33.1 µM -0.223261572086567 0.439928741153733 no 1920 0.411665966729358 2908 6822282 SGTC_3237 9133362 49.47 µM -0.223940808427581 0.439692341266799 no 1921 0.411401680731611 2924 43845137 SGTC_1322 1348-1070 12 µM -0.224221575878747 0.439594629871331 no 1922 0.411292447861744 2795 6758089 SGTC_419 nsc-638432 893 µM -0.224294099557171 0.439569391112495 no 1923 0.411264233566158 2886 368090 SGTC_632 0781-2353 4.65 µM -0.224428172647286 0.439522733364967 no 1924 0.41121207556444 2883 6811515 YHR007C ERG11 SGTC_858 0438-0351 2.77 µM -0.226979156339388 0.438635145883169 no 1925 0.410219975014721 2832 2799119 SGTC_899 1083-0020 478 µM -0.22884549054837 0.437985970038145 no 1926 0.409494504242242 2988 767123 SGTC_3130 9127414 49.47 µM -0.229205051036813 0.437860921530734 no 1927 0.409354773458994 2776 1494646 SGTC_2997 9067075 71.4286 µM -0.229342624771097 0.437813077563532 no 1928 0.40930131321673 2913 27209819 SGTC_1540 guanosine 70.6 µM -0.230150234963818 0.437532233617949 no 1929 0.408987515288715 2778 6802 Guanosine is a purine nucleoside SGTC_2312 7706453 155.7 µM -0.230651835063561 0.437357819568314 no 1930 0.408792647304246 2864 976098 SGTC_1440 4100-1550 40 µM -0.231607559218978 0.437025533337015 no 1931 0.408421417869716 2824 742806 SGTC_1588 farnesol 29.9 µM -0.233333066692112 0.436425721449087 no 1932 0.407751391814665 2823 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_2187 6125751 200 µM -0.234507766062177 0.436017462128309 no 1933 0.407295402411567 2854 874498 SGTC_3047 9092122 49.47 µM -0.23519251793873 0.435779512373552 no 1934 0.407029656481458 2882 17173831 SGTC_451 chloral hydrate 100 µM -0.23712597653439 0.435107765571954 no 1935 0.406279530309754 2943 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1 SGTC_392 N-ethylmaleimide 8.33 µM -0.237204429061323 0.435080512536156 no 1936 0.406249100232908 2867 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides. SGTC_732 3970-1727 52.7 µM -0.238103393836204 0.434768249940591 no 1937 0.405900451264321 2940 1275699 SGTC_2250 alverine citrate 130 µM -0.239217021160041 0.434381479031972 no 1938 0.405468652396312 2765 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1 SGTC_1796 st049173 110.4 µM -0.240596105979966 0.433902599870583 no 1939 0.40493408426128 2877 94134 SGTC_938 3126-1755 342 µM -0.240876288022833 0.43380532012243 no 1940 0.404825500263077 2995 1777771 SGTC_2252 omeprazole 400 µM -0.2413925689772 0.433626076879562 no 1941 0.40462543579549 2891 4594 A proton pump inhibitor. SGTC_1631 benzylvanillin 81.9 µM -0.24295405824576 0.433084039771337 no 1942 0.404020493715178 2976 75506 SGTC_32 0928-0142 34.1 µM -0.243145034825325 0.433017755014609 no 1943 0.403946522522833 2870 2244242 SGTC_3346 9158254 43.5805 µM -0.244277921659095 0.432624587868589 no 1944 0.403507790786076 2928 17639500 SGTC_2400 5203494 178.7 µM -0.244534203500724 0.432535654770474 no 1945 0.4034085576407 2790 6777674 SGTC_1388 3346-4487 254 µM -0.245601510013987 0.432165322474544 no 1946 0.402995360105765 2921 3345614 SGTC_628 1636-0253 16 µM -0.24720187125961 0.431610143474709 no 1947 0.402375998591791 2931 4456143 SGTC_1578 josamycin 24.2 µM -0.248023900154291 0.431325027057986 no 1948 0.402057957397591 2851 5282165 A P450 substrate. SGTC_2798 7813637 45.45 µM -0.24945917178867 0.430827296468269 no 1949 0.401502809470826 2987 956368 SGTC_816 0325-0417 81.3 µM -0.24947818888173 0.430820702362438 no 1950 0.4014954551915 2902 68101 SGTC_306 1672-3436 11.6 µM -0.250869457086613 0.430338337756482 no 1951 0.400957519560451 2935 6797378 SGTC_2429 5902844 64.44 µM -0.251832348048225 0.43000455602488 no 1952 0.400585326399244 3020 1927790 YGL093W | YPR107C SPC105 | YTH1 SGTC_164 4100-3994 89.624 µM -0.253769942372364 0.42933304967209 no 1953 0.399836647972659 2921 4615967 SGTC_357 1325-0123 420 µM -0.253963835665306 0.429265863865796 no 1954 0.399761748620729 2986 1098503 SGTC_973 1325-0077 65.9 µM -0.2556277785364 0.428689376823984 no 1955 0.399119133359377 2913 2835149 SGTC_404 fumagillin 50 µM -0.256857551633782 0.428263409245344 no 1956 0.398644370130665 2909 12015870 A methionine aminopeptidase binder. SGTC_2146 5545642 200 µM -0.257086034163726 0.428184276885694 no 1957 0.398556179214567 2876 825326 SGTC_2691 st077356 60.2 µM -0.257204219818366 0.428143345743806 no 1958 0.398510563312259 3028 2839272 SGTC_3189 9110682 49.47 µM -0.258884113116426 0.427561633458487 no 1959 0.397862328160892 2967 17122418 SGTC_1246 0422-0085 105 µM -0.260361456213366 0.427050190178831 no 1960 0.397292485701553 3001 264295 SGTC_526 4469-0568 170 µM -0.260382908557778 0.427042764465525 no 1961 0.397284212690252 2850 2901964 SGTC_560 2332-1943 155 µM -0.262441820794694 0.42633019419313 no 1962 0.396490416951619 2851 21177716 SGTC_1510 1123-0200 71.5 µM -0.262651625363197 0.42625759625305 no 1963 0.396409552643185 3057 5378812 YNL149C | YNL150W PGA2 | YNL150W SGTC_1895 st058434 18.3 µM -0.26393498338121 0.425813574852721 no 1964 0.395915009153437 3045 5393175 SGTC_1926 methyl fluorone black 53.6 µM -0.265778132363258 0.425176039376316 no 1965 0.395205042765374 2874 72721 Reacts with homocysteine. SGTC_1875 nocodazole 6 µM -0.267003185339107 0.424752408150232 no 1966 0.394733354277315 2928 4122 A microtubule depolymerizer. YJL014W CCT3 SGTC_991 3996-0057 64.7 µM -0.267184806281765 0.424689609840473 no 1967 0.394663436940139 2964 715343 SGTC_310 1273-0058 1.06 µM -0.268169309103242 0.424349235741242 no 1968 0.394284498907414 2998 2734232 SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM -0.268843409655752 0.424116210151097 no 1969 0.394025093295931 3013 521171 SGTC_2207 7258803 200 µM -0.270181489126299 0.423653736519849 no 1970 0.393510316422465 2963 3666799 SGTC_1558 st069300 45.6 µM -0.270329661867554 0.423602530780371 no 1971 0.393453323836323 2982 24208000 SGTC_520 3584-0023 682 µM -0.270344268776831 0.423597482974441 no 1972 0.393447705615218 2937 1340790 SGTC_2496 diffractaic acid 79.83 µM -0.27040430299938 0.423576736684074 no 1973 0.393424615026613 3131 94870 An apoptosis inducer which activates caspases. SGTC_2 0422-0095 29 µM -0.270581712215379 0.423515429839177 no 1974 0.393356381417144 2907 6790840 SGTC_3027 9089541 49.47 µM -0.271465755965084 0.423209960751446 no 1975 0.393016416966086 2981 9943819 SGTC_2973 9094665 17.96 µM -0.271526510795371 0.423188969453219 no 1976 0.392993056316122 3099 25237061 YIL048W NEO1 SGTC_3254 9136651 49.47 µM -0.272983374521727 0.422685676376943 no 1977 0.392432997795412 2915 16454030 SGTC_2996 9066192 71.4286 µM -0.273317917642783 0.422570121762288 no 1978 0.392304421610417 2932 6472854 SGTC_2855 9016525 58.44 µM -0.27432975480181 0.422220663454306 no 1979 0.391915610127057 2854 43811474 SGTC_1364 1653-0028 37.6 µM -0.275177013694434 0.421928092642629 no 1980 0.391590122960385 2960 5718652 SGTC_958 1222-0007 33 µM -0.275704569418413 0.421745941736874 no 1981 0.391387492862511 3066 7312461 SGTC_2924 9010168 62.78 µM -0.275868023524147 0.421689508793659 no 1982 0.391324717374614 2986 2993929 SGTC_3235 9132602 49.47 µM -0.276051918922223 0.421626020365129 no 1983 0.391254094674804 2992 4912240 SGTC_2454 5-benzylidenerhodanine 10.36 µM -0.277002593715056 0.42129783995273 no 1984 0.390889057275943 3071 1273210 SGTC_2147 5545932 89.7195 µM -0.277956681513015 0.420968536306575 no 1985 0.390522805995741 2927 797404 SGTC_3323 9138564 53.9225 µM -0.278621648302717 0.420739055530038 no 1986 0.390267598705138 3063 43912313 YNL103W MET4 SGTC_1621 st003705 32.4 µM -0.278787109906531 0.420681958728436 no 1987 0.390204103615965 3055 24207032 SGTC_3337 9144342 33.5465 µM -0.278993691532239 0.4206106747431 no 1988 0.390124833028835 2980 17682949 SGTC_443 clozapine 122 µM -0.281648798062173 0.419694724282276 no 1989 0.389106409395674 2905 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_2616 abietic acid 100 µM -0.28176161643813 0.419655814144204 no 1990 0.389063152278117 3048 6708678 Abietic acid is an inhibitor of 5α-reductase. SGTC_3067 9117431 49.47 µM -0.282338997071284 0.419456692575961 no 1991 0.388841793018353 2931 17150885 SGTC_2737 bleomycin 30.5 nM -0.282433533248374 0.419424091797403 no 1992 0.388805552671481 2930 16211318 Bleomycin acts by induction of DNA strand breaks. SGTC_19 0279-0214 38.434 µM -0.283628946580881 0.419011901578172 no 1993 0.388347375768704 2913 3566274 YBR002C RER2 SGTC_952 1185-0122 232 µM -0.283950541322825 0.418901027716046 no 1994 0.388224141725093 2849 678600 SGTC_3239 9133757 49.47 µM -0.284725102766044 0.418634014298985 no 1995 0.387927378548723 2893 17036923 SGTC_3248 9135562 49.47 µM -0.284979437228975 0.418546346125745 no 1996 0.387829947859984 2955 17650701 SGTC_1876 myriocin 605 nM -0.285021099855628 0.418531985553935 no 1997 0.387813988374179 3077 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1 SGTC_841 0251-0215 91.2 µM -0.285778020088472 0.418271103804437 no 1998 0.387524071898786 2958 3888614 SGTC_3263 9137018 49.47 µM -0.286298238123987 0.418091825179299 no 1999 0.38732485372526 2959 43844957 SGTC_2294 7971431 200 µM -0.287177965243841 0.417788690523604 no 2000 0.38698802861465 3043 5741572 SGTC_1745 st081495 74 µM -0.287889978210519 0.417543382236729 no 2001 0.386715479270315 2906 13842402 YBL026W LSM2 SGTC_1976 st070609 63.5 µM -0.287945956788572 0.4175240974176 no 2002 0.386694053762387 2843 682556 SGTC_566 0958-0068 16.5 µM -0.28962093097814 0.416947154825384 no 2003 0.386053126191985 3091 6815365 SGTC_2068 5226020 147 µM -0.289981601897182 0.416822945571076 no 2004 0.385915156362297 2964 1810509 SGTC_3287 9117173 37.0625 µM -0.290544626611492 0.416629065530947 no 2005 0.385699807647898 2980 2789709 SGTC_2062 5245942 200 µM -0.292276085456145 0.416032957322158 no 2006 0.385037770976253 2901 1376160 SGTC_2471 5466956 24.79 µM -0.292741072307079 0.415872904069425 no 2007 0.384860036638335 2936 724419 SGTC_1170 0310-0127 64.8 µM -0.294202178582337 0.415370067199301 no 2008 0.384301708004474 2999 774975 SGTC_1001 4048-4355 44.4 µM -0.295648126484835 0.414872583468054 no 2009 0.383749408026058 2917 21824233 SGTC_1698 5-fluorocytosine 1.055 µM -0.2960166980732 0.414745796845257 no 2010 0.383608664676487 3058 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_1282 0886-0010 32.4 µM -0.299240284049888 0.413637280686338 no 2011 0.382378357211008 3100 2836211 YNL267W PIK1 SGTC_3207 9114163 49.47 µM -0.302472502888466 0.412526486511981 no 2012 0.381145945938524 3204 849233 SGTC_1358 1509-0022 2.48 µM -0.302970490957161 0.41235540844484 no 2013 0.380956175063533 2999 3258434 SGTC_736 0958-0254 92.6 µM -0.303404432179216 0.412206346509879 no 2014 0.380790834191644 3052 6812352 SGTC_2107 5363541 170.161 µM -0.303658269208311 0.412119157531686 no 2015 0.380694126951944 3032 244052 SGTC_210 3551-0445 56.827 µM -0.30484303019342 0.411712268431745 no 2016 0.380242853482701 3067 2865180 YOR207C RET1 SGTC_950 1165-0508 94.1 µM -0.305089418504808 0.411627661822144 no 2017 0.380149025037997 3023 6148369 SGTC_1836 st055642 81 µM -0.306025709088494 0.411306189060493 no 2018 0.379792535603652 2963 8571 SGTC_1347 1493-0251 600 nM -0.307078199351877 0.410944890557456 no 2019 0.379391925481965 3086 3986378 SGTC_1959 st077091 55.8 µM -0.308230223469595 0.410549510703318 no 2020 0.378953578130313 2898 821356 YKL052C ASK1 SGTC_1937 st074714 47.2 µM -0.309397902589579 0.410148850728164 no 2021 0.378509432834269 2907 17250970 SGTC_500 h-89 112 µM -0.309748452751449 0.410028586464082 no 2022 0.378376126799611 3123 449241 Protein kinase A inhibitor; also known to inhibit several other kinases. SGTC_631 k072-0230 41.5 µM -0.312333747195794 0.409141904033432 no 2023 0.37739344769909 3060 5773147 SGTC_1713 st033146 12.748 µM -0.312560736213431 0.409064075384737 no 2024 0.377307206202457 3099 674619 SGTC_2154 5570129 200 µM -0.313901920820189 0.408604291223298 no 2025 0.376797765733409 2970 673366 SGTC_2840 9008771 71.43 µM -0.314695971951236 0.408332134287018 no 2026 0.376496251451299 3073 2992978 SGTC_2124 5246320 200 µM -0.314979657838571 0.408234913121946 no 2027 0.376388549507262 3047 579342 SGTC_728 3030-5151 22.5 µM -0.315455172639341 0.408071963500222 no 2028 0.376208040900933 2955 3125388 SGTC_3292 9120825 59.784 µM -0.317595727997624 0.407338634293366 no 2029 0.375395807529411 3122 24824900 SGTC_471 1-acyl-paf 4 µM -0.318253115204139 0.407113486173632 no 2030 0.375146472701897 2956 16759367 SGTC_559 1550-0661 158 µM -0.319535273638689 0.406674448922742 no 2031 0.374660323845744 3038 5830875 SGTC_2990 9074105 71.4286 µM -0.319607366908264 0.406649766191302 no 2032 0.374632994549654 3052 6502001 SGTC_2669 eugenol 100 µM -0.321583157954629 0.405973454940011 no 2033 0.373884252308737 3037 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism. SGTC_2984 9022109 38.96 µM -0.322742535785533 0.4055767315559 no 2034 0.373445117804385 3089 6459207 SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM -0.323560201634165 0.40529699567032 no 2035 0.373135511410546 3150 688798 SGTC_989 1501-0895 10.3 µM -0.324274735826889 0.405052582287021 no 2036 0.372865022517623 3091 2830112 SGTC_6 0844-0013 19.835 µM -0.325192391097288 0.404738743687887 no 2037 0.372517733516547 3051 1584900 SGTC_2074 5212007 75.395 µM -0.325907401120837 0.404494252330607 no 2038 0.372247207941299 3080 758611 SGTC_1402 3909-7673 35.9 µM -0.327687604920545 0.403885689567565 no 2039 0.371573938117754 2926 5328014 SGTC_1901 st060216 58.6 µM -0.328604037371053 0.40357249767198 no 2040 0.371227498009337 2962 688792 SGTC_1325 1431-0015 227 µM -0.32870768791815 0.403537078860477 no 2041 0.37118832142439 2980 1103340 SGTC_2674 ligustilide 100 µM -0.329054821718666 0.403418464249773 no 2042 0.371057125695692 3067 5319022 A signalling regulator. SGTC_2605 digitonin 300 nM -0.329907894650939 0.403127009472141 no 2043 0.37073477905132 3127 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM -0.330485319193184 0.402929761273105 no 2044 0.370516641828795 3042 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_1481 3346-2004 36 µM -0.330861088286598 0.402801411831331 no 2045 0.370374707579221 3046 2770522 SGTC_2565 isoliquiritigenin 100 µM -0.331499013259089 0.402583543197138 no 2046 0.370133793098885 3125 638278 Binds to benzodiazepine receptor 65X better than valium. SGTC_2526 patulin 37.61 µM -0.332871064405446 0.40211505320229 no 2047 0.369615806156973 3145 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.  SGTC_847 0342-0274 5.54 µM -0.333571548127148 0.401875925604934 no 2048 0.369351445483928 3116 18097 SGTC_322 k048-0136 19.3 µM -0.334690445174637 0.401494038403289 no 2049 0.368929304915529 3083 6823282 SGTC_508 roscovitine 141 µM -0.335376571732213 0.401259905227158 no 2050 0.3686705193412 2981 160355 A CDKinase inhibitor. SGTC_1116 jasmonic acid  1.58368 µM -0.336505818113553 0.400874639486204 no 2051 0.368244732458182 3140 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid. SGTC_2049 5262831 67.185 µM -0.337832102056479 0.400422273414854 no 2052 0.367744858376149 3070 763417 SGTC_62 0180-0423 3.232 µM -0.337899379239666 0.400399330211867 no 2053 0.367719507685225 3043 30102 YGL099W LSG1 SGTC_268 camptothecin 39.6153 µM -0.338084250986827 0.400336286089924 no 2054 0.36764984919731 3088 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_338 4055-0136 114 µM -0.34084496799645 0.399395148726808 no 2055 0.366610147848443 3003 2900563 SGTC_854 0422-0053 192 µM -0.34192783221547 0.399026156059652 no 2056 0.36620260179095 3028 3596728 SGTC_1471 k673-0312 37 µM -0.342590121842981 0.398800521219321 no 2057 0.36595341723486 3051 24099884 SGTC_2638 epoxomicin 18 µM -0.343198953366181 0.398593128801522 no 2058 0.365724396005096 3123 9915668 A protesome inhibitor. SGTC_3209 9113616 49.47 µM -0.343771242990042 0.398398210125328 no 2059 0.36550916419214 3215 16649353 SGTC_157 1348-1695 65.819 µM -0.344248455740771 0.398235693483001 no 2060 0.365329722112466 3017 5380510 SGTC_2164 5685496 200 µM -0.344336601037378 0.398205677192782 no 2061 0.365296580842096 3137 759046 SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM -0.344889055063804 0.398017562668341 no 2062 0.365088889576961 3112 616764 SGTC_3173 9105693 49.47 µM -0.347249126583841 0.39721420897157 no 2063 0.364202083298734 3179 17096658 SGTC_2741 miltefosine 3.04 µM -0.348115969025858 0.396919250452057 no 2064 0.363876545983526 3024 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis. SGTC_1691 st019933 84.6 µM -0.348750247855955 0.396703463171559 no 2065 0.363638408709409 3109 6176082 SGTC_2963 9082507 9 µM -0.349611093359449 0.39641064650659 no 2066 0.363315292215907 3180 16459611 SGTC_2455 5377712 9.75 µM -0.351208875670812 0.39586731568693 no 2067 0.362715825959758 3082 2243908 SGTC_1556 plumbagin 1.48 µM -0.352037271901384 0.395585696536492 no 2068 0.362405155222719 3063 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_468 gf-109203x 121 µM -0.352876348572523 0.39530050206165 no 2069 0.362090571381674 3078 2396 A protein kinase C inhibitor. SGTC_1398 3558-0053 112 µM -0.353546734026264 0.395072684471977 no 2070 0.361839299611016 2959 4532369 SGTC_1099 5-nonyloxytryptamine 2.85 µM -0.353881324806935 0.394958993649042 no 2071 0.361713911615974 3046 23581825 A 5-HT1D beta serotonin receptor agonist. SGTC_2235 salicylic acid 500 µM -0.354631558691355 0.394704103701707 no 2072 0.361432815225578 3078 338 A COX inhibitor and kinase inhibitor. SGTC_3274 9138298 49.47 µM -0.355347289199849 0.394460978186865 no 2073 0.361164716199136 2987 17015756 SGTC_2790 5423970 71.43 µM -0.357095504439742 0.393867302355216 no 2074 0.360510154927169 3214 1376240 YKL165C | YIL048W MCD4 | NEO1 SGTC_1339 1486-1321 22.7 µM -0.35737133055286 0.393773657142548 no 2075 0.360406918243791 3056 3469382 SGTC_3144 9087057 49.47 µM -0.358125795440727 0.393517541561591 no 2076 0.36012458780065 3178 17249618 SGTC_654 1124-0271 80.9 µM -0.358681558787192 0.393328907962095 no 2077 0.359916662803202 3055 5403748 SGTC_215 1287-0124 461.5 µM -0.358985253994302 0.393225840275962 no 2078 0.359803060322077 3068 5560863 SGTC_382 3229-0966 23.2 µM -0.360737617482498 0.392631271800768 no 2079 0.359147800423038 3206 5722370 SGTC_679 0422-0091 41.4 µM -0.360971404522047 0.392551967894225 no 2080 0.359060411888583 3039 627384 YHR062C RPP1 SGTC_1013 4112-3890 241 µM -0.362414738630727 0.392062467234696 no 2081 0.358521063608548 2988 705171 SGTC_1501 4491-0275 38.4 µM -0.363513754179163 0.391689855240429 no 2082 0.358110570146025 3151 5104718 SGTC_1129 3453-1384 223 µM -0.363841618302157 0.391578714884993 no 2083 0.357988141301945 3234 1084452 SGTC_1437 4092-1038 11.6 µM -0.365731613614328 0.390938211456296 no 2084 0.357282676888867 3050 3977136 SGTC_3125 9127534 49.47 µM -0.366338909444966 0.390732466729878 no 2085 0.357056099494256 3109 1639235 SGTC_2109 5483026 200 µM -0.366387706899299 0.390715936049748 no 2086 0.357037895726794 3093 759335 SGTC_2725 haloperidol 53.21 µM -0.366397230273273 0.390712709923976 no 2087 0.357034343094069 3024 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_2156 5649887 115 µM -0.366514142226903 0.39067310559585 no 2088 0.3569907308604 3151 54680440 YKL052C | YBR257W ASK1 | POP4 SGTC_2398 5228213 48.84 µM -0.36952225143089 0.389654489306918 no 2089 0.355869245350985 3260 80771 YMR134W ERG29 SGTC_538 2922-0838 53.3 µM -0.370263500721807 0.38940360098324 no 2090 0.355593083234774 3239 777039 SGTC_1620 st003704 16.5 µM -0.370399094674181 0.389357711907095 no 2091 0.355542574130302 3185 2834414 SGTC_1518 st038567 90.8 µM -0.371258127730357 0.389067025131337 no 2092 0.355222641029406 3125 77966 SGTC_2651 TUB2.036 5 µM -0.371915622023652 0.388844578657803 no 2093 0.354977836725183 3225 15992207 YFL037W TUB2 SGTC_2515 chrysin 20.77 µM -0.3724624932369 0.388659586443937 no 2094 0.35477426621312 3148 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor. SGTC_1668 st014914 51.6 µM -0.373365284493963 0.388354251057345 no 2095 0.354438296702395 3132 2839556 SGTC_1735 st034310 56.75 µM -0.373993573827734 0.388141796380617 no 2096 0.354204548593537 3239 871153 SGTC_1675 st018485 24.5 µM -0.374499453254468 0.387970758669882 no 2097 0.354016381646491 3093 3323024 SGTC_178 4092-0806 87.505 µM -0.376811653671296 0.387189281388246 no 2098 0.353156789834321 3145 2169044 SGTC_3333 9141820 12.094 µM -0.377885802400602 0.386826395966474 no 2099 0.352757714925196 3060 1939433 SGTC_2382 9035899 200 µM -0.378113852497967 0.386749365299267 no 2100 0.352673009058789 3079 6462679 SGTC_428 3448-4153 16.5 µM -0.378145028034328 0.386738835186109 no 2101 0.352661429930104 2985 3834874 SGTC_1234 0326-0494 15.5 µM -0.378887243126427 0.386488162971262 no 2102 0.352385798852182 3205 1547813 SGTC_1439 4092-1168 46 µM -0.379391932677362 0.386317738554179 no 2103 0.352198420183841 3142 2886240 SGTC_271 rotenone 740 µM -0.382084208811798 0.385408977479581 no 2104 0.351199452199178 3196 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria. SGTC_576 1073-0113 22.7 µM -0.383574507512683 0.384906206457213 no 2105 0.350646918691838 3208 5439563 SGTC_3041 9091929 49.47 µM -0.383947064737371 0.384780549782078 no 2106 0.350508841078753 3267 25236887 SGTC_94 0334-0113 514.748 µM -0.385592165867937 0.3842258324062 no 2107 0.349899368059361 3110 6795178 SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM -0.3862340720883 0.384009450043018 no 2108 0.349661660968917 3008 4000243 SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM -0.38733821281789 0.383637336077493 no 2109 0.349252919702766 3456 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W SGTC_1498 4478-3555 97.6 µM -0.388630842139077 0.383201834635833 no 2110 0.348774624047316 3154 3437919 SGTC_2630 antimycin a 100 µM -0.389087854563378 0.383047897260499 no 2111 0.348605578829498 3037 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain. SGTC_421 streptovitacin 30 mM -0.391441203668557 0.382255501893705 no 2112 0.347735570475802 3248 91467 include heat shock SGTC_1432 4049-0298 68.4 µM -0.392903540521744 0.381763367010855 no 2113 0.347195363245269 3195 741646 SGTC_3196 9111891 49.47 µM -0.396790580114117 0.380456153348548 no 2114 0.345760948859268 3121 18891510 SGTC_2002 4023503 131 µM -0.397605823559705 0.380182159038454 no 2115 0.345460383565964 3282 4736863 YCR052W RSC6 SGTC_121 0557-0495 61.343 µM -0.397895147914641 0.380084934767271 no 2116 0.345353738398308 3130 3104427 SGTC_2285 7945142 200 µM -0.400456750647822 0.379224467489505 no 2117 0.344410066135219 3213 2970608 SGTC_848 0368-0089 85.6 µM -0.400544910329137 0.379194864415665 no 2118 0.344377606064542 3217 762535 SGTC_1262 0737-0114 49.6 µM -0.400632819964617 0.379165346009919 no 2119 0.344345239201156 3275 765919 SGTC_917 harmaline 728.087 nM -0.403216431389781 0.378298133086439 no 2120 0.343394506446879 3196 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7 SGTC_3082 9117008 49.47 µM -0.405022237271979 0.377692361236626 no 2121 0.342730582650646 3139 41448529 SGTC_106 0092-0003 11.579 µM -0.405161720752526 0.377645582892479 no 2122 0.342679320232927 3151 1072148 SGTC_2366 9070441 60.58 µM -0.405522942959225 0.377524448741392 no 2123 0.342546578742045 3109 6837235 SGTC_2073 5212005 126 µM -0.408131201679587 0.376650139779292 no 2124 0.341588676989857 3140 691789 SGTC_1313 1220-0047 237 µM -0.408760275253892 0.376439363814744 no 2125 0.34135779753992 3175 3528706 SGTC_746 1095-0025 46.6 µM -0.409164290860419 0.376304014684545 no 2126 0.34120954904376 3284 6749286 SGTC_2598 perillyl alcohol 100 µM -0.40948645649218 0.376196096985332 no 2127 0.341091351936658 3263 10819 An apoptosis inducer. SGTC_1204 4049-0315 18.3 µM -0.410073802282057 0.375999375256956 no 2128 0.340875904858183 3325 588402 SGTC_309 k408-0051 1.48 µM -0.410180972491287 0.375963483847589 no 2129 0.340836598843973 3183 3640463 SGTC_1686 st019653 115.5 µM -0.411732472107613 0.375444005434812 no 2130 0.340267760717316 3250 97252 SGTC_2001 4023502 57.655 µM -0.413620232117901 0.374812243690561 no 2131 0.339576126876899 3219 108941 YCR052W RSC6 SGTC_2541 muurolladie-3-one 83.07 µM -0.414987016101504 0.374355042357704 no 2132 0.33907570401848 3300 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils.  YMR203W TOM40 SGTC_2268 7933382 153.85 µM -0.415934019949683 0.374038364738135 no 2133 0.338729142317638 3204 935025 YOR257W CDC31 SGTC_3075 9116269 49.47 µM -0.417114439124864 0.373643752160526 no 2134 0.338297352002192 3313 17015205 YNL244C SUI1 SGTC_163 TUB2.036 7.546 µM -0.418633300160462 0.373136193793048 no 2135 0.337742074431405 3228 15992207 YJR013W GPI14 SGTC_1746 st038117 42 µM -0.419140131137793 0.37296687482306 no 2136 0.337556861528915 3214 2898218 SGTC_2801 7907800 81.82 µM -0.419241191944104 0.372933115984483 no 2137 0.33751993525088 3220 6620925 SGTC_77 0828-0286 12.516 µM -0.419291669070848 0.372916254727277 no 2138 0.337501492164197 3227 745345 SGTC_3313 9133968 57.047 µM -0.420939878001283 0.372365824937114 no 2139 0.336899492298265 3223 1494643 SGTC_2885 9057732 51.95 µM -0.422679282809121 0.371785222362159 no 2140 0.336264636444403 3287 6471414 SGTC_2354 9060492 162 µM -0.425078888848066 0.37098472735029 no 2141 0.3353895835085 3283 6471895 SGTC_2391 6285546 200 µM -0.426652400301024 0.370460115494097 no 2142 0.334816262603341 3134 846083 SGTC_754 3474-0146 171 µM -0.426705329072275 0.370442473117315 no 2143 0.334796984284065 3125 24762078 SGTC_1628 st004252 77.7 µM -0.428609272416845 0.369808026475726 no 2144 0.334103798244278 3273 692968 SGTC_1405 3909-7894 12 µM -0.42873976477742 0.369764555759421 no 2145 0.334056309380814 3249 7104060 SGTC_1117 retinoic acid 1.10837 µM -0.429047337011228 0.369662101286803 no 2146 0.333944388008602 3300 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR). SGTC_691 1548-0686 185 µM -0.431789858836079 0.368748957857892 no 2147 0.33294707539321 3181 46495133 SGTC_2247 cerulenin 830 nM -0.432102865663112 0.368644786847473 no 2148 0.332833326010004 3359 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12 SGTC_1328 1441-0025 69.2 µM -0.432247107100796 0.36859678546765 no 2149 0.332780912603768 3158 4562601 SGTC_1919 st067113 52.3 µM -0.432281622887411 0.368585299437265 no 2150 0.332768370992358 3273 1268243 SGTC_3302 9125395 16.351 µM -0.433627699263621 0.368137448999416 no 2151 0.332279408498004 3173 17599668 SGTC_533 1222-0222 6.71 µM -0.434429514228686 0.367870763806439 no 2152 0.331988284614326 3318 3982874 SGTC_2693 st077581 40.7 µM -0.434765654171618 0.367758981954175 no 2153 0.331866268697385 3283 25238761 SGTC_1539 benzyladenosine 56 µM -0.434856963319069 0.367728619434823 no 2154 0.331833127338911 3155 92208 A nucleotide analog. SGTC_3317 9138495 8.753 µM -0.435222153445199 0.367607193073652 no 2155 0.331700591927575 3214 17020139 SGTC_2383 9036125 200 µM -0.435469631089297 0.367524913842344 no 2156 0.331610788899691 3146 79580 SGTC_318 1488-0629 67.2 µM -0.436637620611738 0.367136672896057 no 2157 0.33118708738553 3260 3662576 SGTC_1950 st077106 7.18 µM -0.437155750292111 0.366964489509638 no 2158 0.330999199081268 3227 13831864 SGTC_1008 4106-0037 6 µM -0.438980255076659 0.366358388471098 no 2159 0.330337921663745 3093 2905394 SGTC_1882 5615643 20 µM -0.43947944410218 0.366192615717726 no 2160 0.330157086691337 3249 2253075 SGTC_2310 7668677 200 µM -0.43970668662122 0.366117160352284 no 2161 0.3300747795195 3373 2197143 SGTC_2580 diallyl disulphide 81.36 µM -0.440416876220524 0.365881376883898 no 2162 0.329817602088476 3169 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.  SGTC_2676 harmalol 100 µM -0.440929435294261 0.365711238357586 no 2163 0.329632041581305 3273 5459187 A monoamine oxidase inhibitor SGTC_3310 9130229 44.1445 µM -0.441081347510289 0.365660817787805 no 2164 0.329577053227364 3287 7761258 SGTC_1704 st028805 70.8 µM -0.442725506786087 0.365115260184348 no 2165 0.328982145382657 3245 2876101 SGTC_1630 st005209 31.3 µM -0.443420840294898 0.36488461976313 no 2166 0.328730682314791 3318 3367314 SGTC_556 4058-0063 51.5 µM -0.44366639282734 0.364803182264874 no 2167 0.328641898275098 3235 6615692 SGTC_2612 dictamnine 15.46 µM -0.445787790216612 0.364099875137056 no 2168 0.327875271162381 3230 68085 A quinoline derivative and established mutagen. YOR116C RPO31 SGTC_3270 9137563 49.47 µM -0.445917396398877 0.364056921588386 no 2169 0.327828457753137 3245 17015724 SGTC_673 1082-0474 110 µM -0.446185113937328 0.363968201149049 no 2170 0.32773176745509 3208 3098046 SGTC_2510 benzyl isothiocyanate 8.31 µM -0.449945725255428 0.36272272329779 no 2171 0.326374788035666 3238 2346 DNA damaging agent; causes G2/M arrest. SGTC_798 1287-0182 476 µM -0.450430352131278 0.36256232486364 no 2172 0.326200081768458 3346 1649755 SGTC_1841 st054148 70 µM -0.450438960748317 0.36255947586136 no 2173 0.326196978737198 3248 675442 SGTC_1241 0364-0022 50.8 µM -0.45286897620424 0.361755572569483 no 2174 0.325321545830867 3212 4563895 SGTC_3037 9091026 49.47 µM -0.453451421401719 0.361562977162504 no 2175 0.325111858090787 3299 25236398 YIL048W NEO1 SGTC_3288 9119690 36.221 µM -0.45394627648112 0.361399372469488 no 2176 0.324933747422911 3220 17595618 YKL019W RAM2 SGTC_702 1488-0190 94 µM -0.454727592417789 0.361141112174797 no 2177 0.324652613818174 3298 949357 SGTC_3122 9126309 49.47 µM -0.454911251844691 0.361080413599753 no 2178 0.324586543855965 3306 17591206 SGTC_796 1234-0020 70.7 µM -0.454931031263531 0.361073876803656 no 2179 0.324579428702583 3240 46495034 SGTC_93 0109-0045 59.227 µM -0.457309150964915 0.360288240721792 no 2180 0.32372442660316 3307 88733 SGTC_561 1550-0330 72.9 µM -0.457479031077171 0.360232141619477 no 2181 0.323663385359893 3203 6812934 SGTC_2897 9048598 12.99 µM -0.457758795800525 0.360139762144625 no 2182 0.323562870768449 3200 6467404 SGTC_1424 4048-1941 275 µM -0.458088429466816 0.360030926217563 no 2183 0.323444455652664 3326 X1424 SGTC_1159 4092-0538 61.2 µM -0.460340709726309 0.359287589526408 no 2184 0.322635842421434 3236 717301 SGTC_2624 nerol 100 µM -0.462237247358704 0.358662073861568 no 2185 0.321955597581587 3235 637566 A natural product oil. SGTC_1346 1488-2224 62.4 µM -0.462291591413968 0.358644155692841 no 2186 0.321936114382696 3329 3722427 SGTC_364 0083-0097 67.7 µM -0.465583234193181 0.35755942600458 no 2187 0.320756923021834 3328 5207356 SGTC_1216 1165-0504 9.65 µM -0.470324088719108 0.355999144276396 no 2188 0.319061744903396 3346 6304004 SGTC_2941 9056145 11.23 µM -0.471485323914321 0.355617331721968 no 2189 0.318647098820994 3293 2119517 SGTC_2451 5856223 45.7 µM -0.472459388150815 0.355297172395303 no 2190 0.318299461506585 3241 2179896 SGTC_1390 3413-2614 145 µM -0.474117321838937 0.354752471018726 no 2191 0.317708123495771 3278 3421432 SGTC_3275 9138069 49.47 µM -0.479556392253287 0.352967595534181 no 2192 0.315771430287569 3324 17617007 SGTC_1047 2043-3044 82 µM -0.480963385396506 0.352506403573694 no 2193 0.315271260904747 3242 669592 SGTC_2825 7998094 58.44 µM -0.486042944616123 0.350843205650003 no 2194 0.313468359105046 3270 2987815 SGTC_2943 9068529 45.32 µM -0.486375138911873 0.350734534504405 no 2195 0.313350606969026 3340 3270634 SGTC_2467 5474540 200 µM -0.486617809514858 0.350655157077114 no 2196 0.31326460011116 3231 5413519 SGTC_45 0kpi-0036 14.9 µM -0.486859560560336 0.350576086919143 no 2197 0.31317892925924 3371 2795021 SGTC_1655 st012546 55.1 µM -0.488758119230645 0.349955345564799 no 2198 0.312506475800392 3319 720985 YLR208W SEC13 SGTC_1793 st048256 72.231 µM -0.48919223415739 0.349813466188664 no 2199 0.312352803501432 3310 672022 SGTC_2195 6536160 144.242 µM -0.489625551068929 0.349671868534648 no 2200 0.312199446233112 3233 3834386 SGTC_1615 st002656 86.5 µM -0.489689227404503 0.34965106238533 no 2201 0.312176912976653 3365 1584458 SGTC_1428 4049-0204 61.7 µM -0.491043369568424 0.349208705423616 no 2202 0.311697886773929 3364 X1428 SGTC_63 0099-0242 26.702 µM -0.494109717967237 0.34820778053738 no 2203 0.310614347540381 3386 3898502 YLR359W ADE13 SGTC_3097 9117246 49.47 µM -0.495629790173674 0.347711986055425 no 2204 0.310077815396509 3388 16423892 SGTC_410 α-linolenic acid 100 µM -0.497877704176585 0.34697927232011 no 2205 0.309285121515301 3391 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_745 0469-0705 296 µM -0.497971554001612 0.346948694127861 no 2206 0.309252046012987 3486 3486736 SGTC_1474 0330-0125 5.35 µM -0.499307292401501 0.346513591368079 no 2207 0.308781459272464 3389 X1474 SGTC_223 busulfan 5 mM -0.500889160176137 0.345998576380674 no 2208 0.308224565875178 3350 2478 A DNA alkylator. SGTC_687 k029-0044 34.9 µM -0.501953474735336 0.345652223430907 no 2209 0.307850124208648 3378 5829338 SGTC_1821 st053465 65.6 µM -0.502067638752886 0.345615079443801 no 2210 0.307809971482721 3316 675086 SGTC_1106 tegaserod maleate 11.7 µM -0.502229004908322 0.345562580476957 no 2211 0.307753221177337 3316 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation. SGTC_2248 tofa 1.1 µM -0.502245913080103 0.345557079733584 no 2212 0.307747275067025 3206 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_2886 9058944 51.95 µM -0.503294086880665 0.345216140581107 no 2213 0.307378761588566 3232 4949929 SGTC_2298 7976326 193.81 µM -0.504030135280648 0.344976801393908 no 2214 0.307120100267249 3299 2235818 SGTC_651 3253-0966 34.4 µM -0.504967198410211 0.344672188435928 no 2215 0.306790937408001 3307 781462 SGTC_3182 9108849 49.47 µM -0.505029033196773 0.344652091218985 no 2216 0.306769222131184 3386 17133045 SGTC_3219 9131112 49.47 µM -0.507178359035096 0.343953801473684 no 2217 0.306014839010647 3360 17612988 YMR079W SEC14 SGTC_836 0330-0104 1.35 µM -0.507641281622094 0.343803473107674 no 2218 0.305852467182824 3352 46494820 SGTC_601 0986-0029 62.9 µM -0.509626327254717 0.343159134380109 no 2219 0.305156637895676 3346 24747981 SGTC_1602 st001878 87.6 µM -0.511511055567954 0.342547779984983 no 2220 0.304496624506378 3418 595405 YLR310C CDC25 SGTC_2532 xanthone 78.9 µM -0.511533545487483 0.342540487355108 no 2221 0.304488752593261 3355 7020 An insecticide. SGTC_228 caffeine 993.056 µM -0.512592998024013 0.342197013538444 no 2222 0.304118026085889 3394 2519 Caffeine is a phosphodiesterase inhibitor. SGTC_2379 9035213 200 µM -0.513810290861439 0.341802529131486 no 2223 0.303692316179323 3408 646551 SGTC_1802 st050112 57.9 µM -0.514364422239807 0.341623010619555 no 2224 0.303498614283846 3345 4662563 SGTC_180 1486-1293 102.781 µM -0.514914868207382 0.341444721506652 no 2225 0.303306255311298 3463 4140536 SGTC_686 1319-0111 510 µM -0.514984746084562 0.341422090634674 no 2226 0.303281839671032 3445 4562600 SGTC_37 0566-0070 1.56 µM -0.51591397695063 0.341121201198541 no 2227 0.302957245844414 3341 1626686 SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM -0.51637179997663 0.340972993022427 no 2228 0.30279737881188 3363 91467 include heat shock SGTC_2523 spermine 47.74 µM -0.518637592167465 0.340239863924765 no 2229 0.302006744551294 3374 1103 A DNA binding polyamine. SGTC_610 4215-0184 155 µM -0.519275522696934 0.340033561238659 no 2230 0.301784310003839 3379 5605015 SGTC_782 0083-0095 30.5 µM -0.519371479078228 0.340002533695617 no 2231 0.301750858165465 3386 3591729 An indicator and reagent. SGTC_176 1486-1328 72.834 µM -0.524398548282803 0.338378548301041 no 2232 0.300000683016498 3372 22310231 SGTC_99 0109-0120 622.8 µM -0.525483087404531 0.338028582553495 no 2233 0.299623703669555 3476 759414 SGTC_539 4859-0462 2.54 µM -0.525917609158902 0.337888407650643 no 2234 0.299472726739498 3407 46499474 YNL221C | YBR257W POP1 | POP4 SGTC_3021 9087658 49.47 µM -0.526365435664641 0.337743964211931 no 2235 0.29931716310027 3413 25237042 SGTC_1267 0828-0272 9.49 µM -0.526527121837576 0.337691819290153 no 2236 0.299261006407075 3464 745334 SGTC_996 3970-0799 1.8 µM -0.527537004468963 0.337366195615068 no 2237 0.298910363118501 3399 6615648 YGL040C HEM2 SGTC_1678 st019265 80.2 µM -0.528429633788564 0.337078480131088 no 2238 0.298600587058518 3478 5367020 SGTC_3009 9080819 71.4286 µM -0.528922843257805 0.336919547940935 no 2239 0.298429487406414 3372 17027216 SGTC_789 1309-1135 70.6 µM -0.529048551256943 0.336879044355309 no 2240 0.298385885089783 3415 3092424 SGTC_51 1013-0126 23.419 µM -0.530807885807627 0.336312378883544 no 2241 0.297775957444416 3550 1627850 SGTC_1532 4',5'-dihydroxyflavone 78.7 µM -0.531046665047838 0.336235498903813 no 2242 0.297693221096305 3419 165521 SGTC_606 k015-0008 38.6 µM -0.532222177176043 0.335857118040368 no 2243 0.297286062397804 3440 1970475 SGTC_231 b-estradiol 524 µM -0.532547802969464 0.335752333066359 no 2244 0.297173321367213 3300 450 A steroid. SGTC_2136 5328288 199.296 µM -0.532641696978751 0.335722120751084 no 2245 0.297140816186994 3312 262395 SGTC_1065 prochlorperazine maleate 2.48 µM -0.533316089702412 0.335505152329763 no 2246 0.296907395856903 3441 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine. SGTC_2664 lyso-paf C-16 73.48 µM -0.533999713822288 0.335285269916786 no 2247 0.29667086603211 3338 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_2625 euphol 100 µM -0.534166457158226 0.335231646767962 no 2248 0.296613186936439 3447 6708538 A triterpene alcohol. SGTC_2226 7298446 200 µM -0.534273477152254 0.335197231874628 no 2249 0.296576169773923 3410 3283010 SGTC_1941 st076221 61.8 µM -0.534793652064167 0.335029976631163 no 2250 0.29639627654235 3375 2828568 SGTC_3035 9091303 49.47 µM -0.534845618725748 0.335013269246967 no 2251 0.29637830754623 3417 25237002 SGTC_1240 0356-0016 42.1 µM -0.535065053869984 0.334942724015511 no 2252 0.296302436921931 3337 4305613 SGTC_925 2064-1272 59.6 µM -0.535470178814449 0.334812497495313 no 2253 0.296162386673476 3328 6815817 SGTC_2120 5538279 151.968 µM -0.536021576862441 0.334635283725735 no 2254 0.295971819148526 3409 2058197 SGTC_12 0849-0099 9.267 µM -0.536037724464038 0.334630094604391 no 2255 0.295966239258295 3383 6071388 SGTC_2188 6126565 140.678 µM -0.536400408244375 0.334513552483239 no 2256 0.295840924662064 3414 874518 SGTC_1683 st010134 710 nM -0.538369633711648 0.333881054703833 no 2257 0.295160943155143 3358 3818134 SGTC_1413 3910-0535 34.4 µM -0.541354206163977 0.332923335997099 no 2258 0.294131732389011 3435 2876951 SGTC_18 0111-0177 500 nM -0.541639011658404 0.332832001650171 no 2259 0.294033605772766 3457 721752 SGTC_3093 9117344 49.47 µM -0.542432020682031 0.332577743654763 no 2260 0.293760462955499 3446 24824913 SGTC_1024 4507-0395 26 µM -0.544339872992613 0.331966355415225 no 2261 0.293103806712087 3495 4201836 SGTC_2569 tetrandrine 100 µM -0.544458803486442 0.331928257869648 no 2262 0.29306289504081 3337 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_3044 9093193 49.47 µM -0.544812701426758 0.331814902413873 no 2263 0.292941171066095 3422 25236277 SGTC_1381 2324-0066 62.1 µM -0.544987797196187 0.331758823968591 no 2264 0.292880955168135 3408 10885928 SGTC_479 n-linoleoylglycine 10 µM -0.545678899540004 0.331537519369243 no 2265 0.292643339353565 3389 6433346 An anti-infammatory. SGTC_1663 st014140 55.4 µM -0.546758071153883 0.33119206494549 no 2266 0.292272476206953 3487 4207120 SGTC_801 0866-0028 10.1 µM -0.547188426926993 0.331054343481049 no 2267 0.292124643120997 3416 6849771 SGTC_911 3456-4043 236 µM -0.549044414116928 0.330460656755673 no 2268 0.291487485178329 3417 914281 SGTC_2503 beta-caryophyllene alcohol 24.72 µM -0.549379483484312 0.330353521329795 no 2269 0.291372525417835 3451 61125 An anti-inflammatory. SGTC_2700 st077718 96.8 µM -0.549444723948363 0.330332662893306 no 2270 0.291350144369875 3398 904970 SGTC_892 0929-0076 29 µM -0.549671945290154 0.33026002065376 no 2271 0.291272201283375 3371 5751038 SGTC_1524 corynanthine 62.1 µM -0.550975538665873 0.329843387978846 no 2272 0.290825221586661 3466 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist. SGTC_278 4092-0821 23.9 µM -0.551451676940885 0.329691265224683 no 2273 0.29066204196862 3433 877900 SGTC_1318 1280-3875 124 µM -0.552804693288665 0.329259140067906 no 2274 0.290198577205757 3428 373245 SGTC_1198 1612-1005 86.7 µM -0.553295805002224 0.329102345611383 no 2275 0.290030436561862 3532 6998509 SGTC_3186 9110464 49.47 µM -0.555184860590148 0.328499517916966 no 2276 0.289384111554415 3483 17018021 SGTC_1653 st012112 65 µM -0.555604617276509 0.328365627405888 no 2277 0.289240587158242 3476 720429 SGTC_625 k213-0058 121 µM -0.555684986664463 0.3283399943577 no 2278 0.289213110846275 3468 3655420 SGTC_1019 4262-0212 3.4 µM -0.558239103861898 0.327525804540894 no 2279 0.288340560947768 3474 4677213 SGTC_1349 flufenamic acid 69 µM -0.558314074970792 0.327501917956452 no 2280 0.288314967716421 3409 3371 A non-steroidal anti-inflammatory. SGTC_1359 1582-0056 520 nM -0.559840703071682 0.327015671874184 no 2281 0.287794048818593 3469 3661189 SGTC_1451 4152-0210 104 µM -0.560444308845597 0.326823498414487 no 2282 0.287588208043077 3486 659563 SGTC_2436 5633522 8.09 µM -0.562119996830297 0.326290240795288 no 2283 0.287017132411107 3492 5724242 SGTC_2440 5628896 157.78 µM -0.563449858491029 0.325867288720706 no 2284 0.286564297248249 3423 5522048 SGTC_1792 st045773 43.6 µM -0.563569796702138 0.325829154316922 no 2285 0.286523473396747 3423 2919270 SGTC_171 k064-0041 9.68 µM -0.564557260587737 0.325515259054259 no 2286 0.28618747125591 3370 53325 SGTC_795 0685-0265 78 µM -0.565063611081892 0.325354348201563 no 2287 0.286015249116626 3534 302754 SGTC_971 1315-0384 26.7 µM -0.56513742512007 0.325330893887318 no 2288 0.285990147277847 3418 6769120 SGTC_3091 9116372 49.47 µM -0.565548137956111 0.325200403056384 no 2289 0.285850495851478 3509 17169793 SGTC_599 1935-0052 86.5 µM -0.565819412873643 0.325114225904198 no 2290 0.285758274179186 3385 9557311 SGTC_1395 3486-0190 4.35 µM -0.565975948730969 0.325064502693493 no 2291 0.285705065236514 3520 6748079 SGTC_2480 5767542 37.17 µM -0.566980916620662 0.324745351476013 no 2292 0.285363573527592 3433 2867358 SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM -0.568530756458241 0.324253415512412 no 2293 0.284837313769251 3539 1377 SGTC_185 k048-0037 25.491 µM -0.568901286373467 0.324135850685758 no 2294 0.284711566173346 3492 6827589 SGTC_1722 st034304 3.6505 µM -0.569454834824356 0.323960248876746 no 2295 0.28452375653091 3405 4036148 YLR033W RSC58 SGTC_3345 9148410 3.559 µM -0.57116073128058 0.32341933495537 no 2296 0.283945347124459 3479 4903596 SGTC_50 0929-0078 56.389 µM -0.572515020120874 0.322990175997523 no 2297 0.283486556526785 3321 1377751 SGTC_642 0335-0876 158 µM -0.573366847815681 0.322720361980814 no 2298 0.283198166143495 3475 6812350 SGTC_3033 9090887 49.47 µM -0.573852206852309 0.322566667595923 no 2299 0.283033908463529 3413 19325384 SGTC_313 3474-0040 5.03 µM -0.575053301300162 0.322186457935339 no 2300 0.282627624674497 3440 1043375 YIL048W NEO1 SGTC_174 3553-0389 74.3 µM -0.576850949761243 0.321617755074274 no 2301 0.282020073973212 3501 738071 SGTC_804 1595-0054 20.9 µM -0.577000506489014 0.32157046021429 no 2302 0.281969556686486 3398 761523 Stimulates phospholipase C. SGTC_2883 9059145 45.46 µM -0.577209904019373 0.321504246541985 no 2303 0.281898833691943 3407 16476510 SGTC_1166 k206-0078 225 µM -0.577633010881595 0.321370473068352 no 2304 0.281755957499438 3482 5404595 SGTC_2420 aureobasidin a 50 nM -0.579094816757243 0.320908473056994 no 2305 0.281262598624321 3559 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1 SGTC_1088 bifonazole 369 nM -0.579632120803655 0.320738729108609 no 2306 0.281081363616826 3443 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase. SGTC_2083 5306046 65.942 µM -0.580616322036739 0.320427899559759 no 2307 0.280749534620409 3479 539837 SGTC_1016 4226-1401 38 µM -0.583217757146705 0.319606923393171 no 2308 0.279873359397642 3487 2901613 SGTC_1345 1488-0192 31.4 µM -0.584059994723863 0.319341314181743 no 2309 0.279589974393672 3525 658348 SGTC_358 0075-0058 9.45 µM -0.584101878910938 0.319328107944423 no 2310 0.279575885390795 3560 1069125 SGTC_2838 9002687 71.43 µM -0.58469629510499 0.319140711060711 no 2311 0.279375972835372 3434 6457060 SGTC_1163 k060-0048 49.9 µM -0.584898214799293 0.319077063950205 no 2312 0.279308079517637 3498 6809982 SGTC_874 0599-0792 117 µM -0.585605277694517 0.318854232688382 no 2313 0.279070400458526 3543 765305 SGTC_1756 st041558 35.5 µM -0.585860358273628 0.31877385996788 no 2314 0.278984679316803 3576 3955792 SGTC_374 0880-0231 82.3 µM -0.586468709233659 0.318582210549629 no 2315 0.278780291555837 3483 6833587 SGTC_2859 9028643 45.46 µM -0.58906732608256 0.31776411249033 no 2316 0.277908055352507 3466 17151580 SGTC_1151 3909-8316 15.3 µM -0.59047760550735 0.317320499313192 no 2317 0.277435247644243 3517 800431 SGTC_2614 arthonioic acid 13.39 µM -0.591098247690963 0.317125355087036 no 2318 0.277227296952795 3473 6710684 SGTC_3098 9119039 49.47 µM -0.594762031101514 0.31597441445819 no 2319 0.276001275468513 3516 17161528 SGTC_1972 st070201 17.4 µM -0.596046883210279 0.315571212452254 no 2320 0.275571953524878 3512 2829099 SGTC_3234 9132280 49.47 µM -0.597493276273779 0.315117579528307 no 2321 0.275089047368984 3527 17612295 SGTC_617 3770-0098 35 µM -0.598250793171148 0.314880110301773 no 2322 0.274836302183201 3477 5962639 SGTC_43 0570-0105 72.5 µM -0.598975410572041 0.314653026131237 no 2323 0.274594641061184 3534 1114046 YDL195W SEC31 SGTC_1256 0570-0116 285 µM -0.599011582809332 0.314641692133273 no 2324 0.274582580306568 3465 410638 SGTC_3276 9139060 49.47 µM -0.600877371851146 0.314057313708616 no 2325 0.273960832840407 3550 4870619 SGTC_1751 st044839 27.194 µM -0.601953826434877 0.313720372311584 no 2326 0.273602436596232 3533 5291326 SGTC_1135 dihydrocapsaicin 536.708 nM -0.602001177961408 0.313705554359337 no 2327 0.273586676643762 3497 107982 A Capsaicinoid. SGTC_661 1304-0007 33.6 µM -0.60250108552887 0.313549134099147 no 2328 0.27342032041199 3505 3117130 SGTC_2942 9052777 62.25 µM -0.605544430733996 0.312597600394967 no 2329 0.272408656126264 3584 6469503 SGTC_377 3970-0964 33.1 µM -0.606440353477196 0.31231771823366 no 2330 0.272111189439593 3520 16481235 SGTC_3103 9120822 49.47 µM -0.609452949179219 0.31137739188025 no 2331 0.271112125271835 3633 17141819 SGTC_2808 7946468 45.46 µM -0.609770268659465 0.311278417895592 no 2332 0.271006999506577 3508 2970879 SGTC_3303 9125618 40.5795 µM -0.610012627582483 0.311202833778167 no 2333 0.27092672135842 3520 22695467 SGTC_247 mechlorethamine 29.705 µM -0.611060571402173 0.310876104751127 no 2334 0.270579740635551 3484 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links. SGTC_2453 5731132 22.18 µM -0.613276172182491 0.310185813314281 no 2335 0.26984687296114 3577 1362040 SGTC_134 0269-0018 6.916 µM -0.61334747155094 0.310163610406499 no 2336 0.269823305352807 3462 4378915 SGTC_1915 st067105 30.6 µM -0.61519268243493 0.309589245272395 no 2337 0.269213739879238 3551 69751 YOR207C | YOR116C RET1 | RPO31 SGTC_2544 sphondin 68.51 µM -0.617617704028033 0.308835107242202 no 2338 0.268413685786385 3566 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31 SGTC_2688 kanamycin b 96.69 µM -0.617705527898414 0.30880781069218 no 2339 0.268384733711679 3654 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis. SGTC_866 0495-0101 262 µM -0.620348365387118 0.307986884620208 no 2340 0.267514229556752 3466 635694 SGTC_927 2425-1185 123 µM -0.620751520577285 0.307861739635694 no 2341 0.267381562597525 3518 730375 SGTC_2424 5537928 59.2 µM -0.622180639200357 0.307418301393169 no 2342 0.266911547622445 3549 5382802 SGTC_541 4513-1321 94 µM -0.625961791881241 0.306246413551039 no 2343 0.265670001386546 3477 747515 SGTC_2786 7743617 45.45 µM -0.626906107131277 0.305954051577595 no 2344 0.265360391907172 3455 583674 SGTC_1330 1469-0054 61.8 µM -0.626932132329969 0.305945995870912 no 2345 0.265351861706177 3562 7102664 SGTC_1275 0867-0008 21.1 µM -0.627649254759985 0.305724058407827 no 2346 0.26511686741385 3516 3422836 SGTC_2315 7733312 200 µM -0.628941774650365 0.305324225207656 no 2347 0.264693587881782 3523 726316 SGTC_1989 st071868 50.2 µM -0.62981825619295 0.305053223004805 no 2348 0.264406749911857 3561 16414057 SGTC_734 2023-0417 80 µM -0.630098523980327 0.304966588631655 no 2349 0.264315062672991 3538 3935732 SGTC_2870 9038528 12.99 µM -0.634975175111723 0.303460906325581 no 2350 0.262722302960294 3572 6463316 SGTC_3138 9097216 49.47 µM -0.637135831685143 0.302794859700367 no 2351 0.262018185300251 3601 25237486 SGTC_2289 7946404 165.07 µM -0.638795640787959 0.302283649991823 no 2352 0.26147794224811 3612 1246120 YPR165W RHO1 SGTC_528 3492-0019 172 µM -0.639989426610747 0.301916211820384 no 2353 0.26108973671434 3599 2869262 SGTC_463 ikarugamyin 104 µM -0.640934286626997 0.301625533460912 no 2354 0.260782689190763 3613 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis. SGTC_1212 0520-0165 585 µM -0.642636034416031 0.301102322619185 no 2355 0.26023014776309 3727 5403258 SGTC_3304 9125678 46.087 µM -0.643984826569073 0.300687920530354 no 2356 0.259792636680605 3577 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2 SGTC_145 3737-0113 38.366 µM -0.64432199413062 0.300584369601256 no 2357 0.259683328123953 3617 6849351 SGTC_529 4076-0302 30.3 µM -0.650146584314397 0.298798068709728 no 2358 0.257798770379452 3567 5816522 SGTC_2023 5144124 124 µM -0.650988559297387 0.298540249162241 no 2359 0.257526936084912 3569 2830192 SGTC_361 000s-0510 1.45 µM -0.651667344188841 0.298332473444538 no 2360 0.257307896672108 3578 660 SGTC_879 0831-1030 162 µM -0.656588066428214 0.29682821522043 no 2361 0.255722912092205 3628 1549252 SGTC_1456 k015-0012 13 µM -0.656662974661792 0.296805342721667 no 2362 0.255698823298482 3669 2989616 SGTC_2302 7771753 200 µM -0.658478087821729 0.296251362410688 no 2363 0.255115486348076 3582 2203047 SGTC_362 0310-0100 9.03 µM -0.658643988277698 0.296200752542962 no 2364 0.255062204373208 3624 790235 SGTC_2718 lomofungin 53.02 µM -0.660190376570266 0.295729199673764 no 2365 0.254565833558677 3635 5351222 A RNA synthesis inhibitor. SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM -0.660511418034498 0.295631345124323 no 2366 0.254462846833573 3597 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair. SGTC_1885 st057546 99.9 µM -0.663278415319227 0.294788572419923 no 2367 0.253576128975895 3662 702008 SGTC_3278 9139605 49.47 µM -0.664671416024631 0.294364711537872 no 2368 0.253130340059911 3651 7958859 SGTC_1376 2910-0861 41.3 µM -0.667136637867784 0.293615286751989 no 2369 0.252342429706281 3631 1112859 SGTC_1051 3253-3903 78 µM -0.667928499040923 0.293374749378848 no 2370 0.252089617314967 3607 5509239 SGTC_3319 9138450 16.7555 µM -0.669115312995933 0.29301441141229 no 2371 0.251710961250373 3591 2029690 SGTC_585 0kpi-0023 191 µM -0.670513352914727 0.292590205056846 no 2372 0.251265298599258 3587 64601 SGTC_3192 9110362 49.47 µM -0.671224653490226 0.292374485158202 no 2373 0.251038712741444 3692 16649480 SGTC_1984 st072354 53.1 µM -0.671612587881596 0.292256865410959 no 2374 0.250915181237999 3573 5762938 SGTC_499 genistein 192 µM -0.673718285872621 0.29161881273664 no 2375 0.250245217057512 3641 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger. SGTC_1736 st036774 51 µM -0.674406200557593 0.291410506858595 no 2376 0.250026550865846 3664 1272247 SGTC_543 3844-1095 191 µM -0.675393979972541 0.291111521089665 no 2377 0.249712744606403 3638 4230703 SGTC_778 3456-2434 196 µM -0.675631756652549 0.291039571113553 no 2378 0.249637236912144 3675 5539063 SGTC_2144 5628481 200 µM -0.675983572135055 0.290933128835493 no 2379 0.249525537627131 3623 2818399 SGTC_295 k015-0027 31 µM -0.676055869233672 0.290911257498337 no 2380 0.249502587025894 3611 3887424 SGTC_1656 st012921 11 µM -0.676273921722262 0.290845296856832 no 2381 0.249433373397181 3582 6732821 SGTC_320 4092-0846 5.34 µM -0.676536123290207 0.290765990425735 no 2382 0.24935015960219 3614 1359356 SGTC_1096 rimcazole 32.2 µM -0.678083467260059 0.290298181229354 no 2383 0.24885938630451 3588 18528119 A dopamine reuptake inhibitor. SGTC_2907 7721985 69.9 µM -0.678245014925898 0.290249360780308 no 2384 0.248808177660768 3603 3267881 SGTC_1311 1190-0148 100 µM -0.678519570052427 0.290166397779428 no 2385 0.248721159898332 3694 1961333 SGTC_689 0833-0039 98 µM -0.679626284399095 0.289832091887161 no 2386 0.248370561194422 3637 5374726 SGTC_1804 st050076 49.1 µM -0.679659014341189 0.289822207884451 no 2387 0.248360196609275 3656 3895976 SGTC_2968 9090663 33.37 µM -0.681387522408472 0.289300446500369 no 2388 0.24781315800902 3629 25236811 SGTC_735 3076-0345 636 µM -0.682083726386534 0.289090417588823 no 2389 0.247593005084897 3672 2888990 SGTC_2866 9034245 58.44 µM -0.683205048856208 0.288752290936001 no 2390 0.247238641379153 3641 6462273 SGTC_2393 9031399 185.94 µM -0.684004416454262 0.288511361182639 no 2391 0.246986188490937 3677 1526623 YDL150W RPC53 SGTC_2557 derrustone 83.84 µM -0.684810486874776 0.288268507163019 no 2392 0.246731758482676 3652 629853 An antioxidant. SGTC_2201 6605497 169.863 µM -0.684953154873204 0.288225533993618 no 2393 0.246686741034417 3650 670741 SGTC_2708 st078559 56 µM -0.685057797664363 0.288194016355744 no 2394 0.246653724853353 3587 17250902 SGTC_2828 7998861 71.43 µM -0.685901597130078 0.287939929604327 no 2395 0.246387581493665 3571 2988188 SGTC_2750 bromebric acid 70.15 µM -0.686661375763388 0.287711233925678 no 2396 0.246148070951411 3688 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2 SGTC_3342 9147791 14.508 µM -0.686854638994558 0.28765307480112 no 2397 0.246087167104686 3618 1838168 SGTC_994 3910-0338 138 µM -0.687525181258647 0.28745133015295 no 2398 0.245875919018854 3726 3479481 SGTC_2872 9044037 25.97 µM -0.692264630646034 0.286027293421429 no 2399 0.24438557876578 3654 6465195 SGTC_1946 st076057 65.1 µM -0.693134464037314 0.285766303841614 no 2400 0.244112585587199 3551 953009 SGTC_2069 5228469 200 µM -0.693408488734068 0.285684107437932 no 2401 0.244026618283738 3633 2835210 SGTC_1612 st002233 45.4 µM -0.694207314876438 0.285444555889799 no 2402 0.243776102963132 3679 1035021 SGTC_2817 7995342 71.43 µM -0.69459606519955 0.28532801226328 no 2403 0.243654239421853 3646 18879975 SGTC_2803 7707263 71.43 µM -0.695873797230113 0.284945120188198 no 2404 0.243253934099802 3664 2199229 SGTC_1329 1447-1697 50.6 µM -0.697187279654105 0.284551770585517 no 2405 0.242842799250045 3655 2840515 SGTC_2809 7964133 12.99 µM -0.699217965844479 0.28394415028757 no 2406 0.242207912290068 3691 1253665 SGTC_2705 st078069 42.8 µM -0.699307417721095 0.283917398852789 no 2407 0.242179966177637 3661 1530061 SGTC_3080 9117754 49.47 µM -0.700035874567034 0.283699591822305 no 2408 0.241952450389063 3719 9550191 SGTC_1372 2752-0194 270 µM -0.700343269185149 0.283607705508196 no 2409 0.241856477948796 3653 823334 SGTC_663 1486-0733 13.9 µM -0.700690037987488 0.283504066591154 no 2410 0.241748237194186 3677 722445 YPR165W RHO1 SGTC_1530 rhein 70.4 µM -0.701031405790726 0.283402059604585 no 2411 0.241641707998395 3717 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death. SGTC_915 methyl methanesulfonate (MMS) 110 mM -0.701077303181161 0.283388345961071 no 2412 0.2416273869392 3718 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks. SGTC_3147 9097027 49.47 µM -0.702025391241906 0.283105138696168 no 2413 0.241331664387208 3701 25236841 SGTC_393 acivicin 6.25 µM -0.70337874712502 0.282701107689511 no 2414 0.240909873798603 3587 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1 SGTC_1988 st071872 53.4 µM -0.703569113679201 0.282644297874274 no 2415 0.240850575825398 3683 16414116 SGTC_1475 4092-1048 11.7 µM -0.705004960184968 0.2822159846784 no 2416 0.240403574677744 3683 2881759 SGTC_2015 5119600 184 µM -0.705132414675545 0.282177980088145 no 2417 0.240363917978088 3683 2828786 SGTC_68 0986-0284 82.829 µM -0.706712396662577 0.281707063124091 no 2418 0.239872612092589 3685 423278 YIL048W NEO1 SGTC_133 0724-0033 378.92 µM -0.707220495459338 0.281555703759109 no 2419 0.239714731880528 3585 280309 SGTC_1516 st013856 110 µM -0.708190966025707 0.281266715875581 no 2420 0.239413337747468 3687 5281404 A mutagen and neurotoxin. SGTC_3107 9121808 49.47 µM -0.708213308214849 0.281260064478584 no 2421 0.239406401484764 3630 662681 SGTC_831 k061-1017 217 µM -0.708533796536451 0.281164661638105 no 2422 0.239306916098919 3741 1240153 SGTC_135 0933-0004 26.348 µM -0.708553283722018 0.281158861204271 no 2423 0.239300867651635 3668 21230617 YGL099W LSG1 SGTC_2649 anisomycin 9.56 µM -0.710507634908957 0.280577434981022 no 2424 0.238694699033526 3673 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_2774 tamoxifen 10.92 µM -0.710657334143405 0.280532922942884 no 2425 0.238648302446077 3709 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  SGTC_54 0159-0055 9 µM -0.710719541065969 0.280514427147339 no 2426 0.238629023979959 3722 3319099 SGTC_902 1120-0002 2.07 µM -0.711292320410817 0.280344152144166 no 2427 0.23845155473993 3695 3280475 SGTC_2116 5511452 16.8835 µM -0.713207583704988 0.279775149260031 no 2428 0.237858657095952 3697 870744 SGTC_1271 0832-2808 169 µM -0.713705032151219 0.279627454713253 no 2429 0.237704797044009 3714 3663794 SGTC_697 0508-1955 564 µM -0.714546663740794 0.279377656950624 no 2430 0.237444606046949 3669 6243113 SGTC_283 0987-0079 11.7 µM -0.714753717023083 0.279316219784614 no 2431 0.237380619351309 3721 411556 SGTC_763 3453-1109 128 µM -0.71662793523563 0.278760397738557 no 2432 0.236801851404662 3703 1560353 SGTC_2933 9026794 32.47 µM -0.716669899231082 0.278747958973608 no 2433 0.236788901600946 3718 17586027 SGTC_1152 3909-8331 15.9 µM -0.716849779961445 0.278694642657381 no 2434 0.236733396043245 3684 16001939 SGTC_2974 9094440 9.66 µM -0.717117914389555 0.278615177325667 no 2435 0.236650671444862 3780 25236134 SGTC_44 0929-0055 61.211 µM -0.717540380891483 0.27848999595072 no 2436 0.236520364723253 3653 1379590 SGTC_1396 3511-0007 98.6 µM -0.718277513606022 0.27827164122484 no 2437 0.236293096077881 3665 X1396 SGTC_516 3992-2719 87.3 µM -0.718560212904697 0.278187921699344 no 2438 0.236205967719283 3682 5350887 YDR037W KRS1 SGTC_2339 9000433 200 µM -0.719599077717116 0.277880374309533 no 2439 0.235885940021892 3706 2988954 SGTC_417 st075190 100 µM -0.719924567277158 0.277784049958262 no 2440 0.235785720468661 3705 222757 SGTC_1509 1326-1131 80 µM -0.720317975640778 0.277667647697432 no 2441 0.235664619783731 3661 768313 SGTC_3213 9129884 49.47 µM -0.720413182669205 0.277639481279252 no 2442 0.235635317895758 3668 17190742 SGTC_1910 st062352 60.4 µM -0.720686369563871 0.277558668353562 no 2443 0.235551250262545 3656 2245730 SGTC_1090 efavirenz 20.7 µM -0.722807868892218 0.27693148741681 no 2444 0.234898966117063 3763 64139 A non-nucleoside reverse transcriptase inhibitor. SGTC_2212 7123476 200 µM -0.723440563449078 0.276744577721684 no 2445 0.234704628893481 3669 1085715 SGTC_429 1112-0049 25.5 µM -0.724202709696939 0.276519507696256 no 2446 0.234470647630813 3694 2836170 SGTC_1884 5633444 25 µM -0.726129701314208 0.275950846854958 no 2447 0.233879631270828 3736 5724239 SGTC_2891 9063876 19.48 µM -0.728230014354161 0.275331693289447 no 2448 0.233236397779338 3714 6472478 SGTC_1640 st009078 66.4 µM -0.729884014022661 0.27484459059836 no 2449 0.232730542295422 3719 690618 SGTC_1035 k081-0041 55.2 µM -0.730956748889813 0.274528897556228 no 2450 0.232402785749488 3724 731709 SGTC_986 1493-0483 84 µM -0.731535810655351 0.274358560988352 no 2451 0.232225969678103 3656 40079 SGTC_1776 st049249 45.9 µM -0.731571374566365 0.274348101223888 no 2452 0.23221511270533 3758 1822314 SGTC_2755 lomerizine 42.69 µM -0.73180378893074 0.274279750273519 no 2453 0.232144168059341 3728 3949 A calcium channel blocker. SGTC_532 1548-0774 215 µM -0.732575618192873 0.274052822654674 no 2454 0.231908653216875 3810 5932993 SGTC_1837 st055472 66.5 µM -0.734037254024275 0.273623337488128 no 2455 0.231463016635014 3782 676091 SGTC_2037 5169046 200 µM -0.736163534028348 0.27299914936502 no 2456 0.23081559073918 3787 5718022 SGTC_1130 3454-2858 15.9 µM -0.736335626817412 0.272948660915381 no 2457 0.23076323489611 3775 715628 YIL048W NEO1 SGTC_1689 st020265 53.493 µM -0.738250313489453 0.272387244126911 no 2458 0.230181176834102 3729 5758320 YPR016C TIF6 SGTC_1981 st071826 47 µM -0.739199348508158 0.272109184633535 no 2459 0.229892978195331 3723 11838600 SGTC_2036 5160441 105 µM -0.740562987166379 0.271709896881194 no 2460 0.229479228475126 3733 134534 YIL048W NEO1 SGTC_967 1306-0166 352 µM -0.740956450004626 0.271594741060747 no 2461 0.229359923192545 3706 4437607 SGTC_1469 k284-2957 126 µM -0.741878252042573 0.271325049992178 no 2462 0.229080551787407 3746 23884841 SGTC_2655 perillic acid 100 µM -0.741974123313004 0.27129700865622 no 2463 0.229051506954711 3757 5702197 An apoptosis inducer. SGTC_245 methotrexate 289.6 µM -0.743359895168594 0.270891846400676 no 2464 0.228631909064905 3734 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2 SGTC_1645 Cervolide 78 µM -0.743880671349261 0.27073966361184 no 2465 0.228474334897323 3720 23173 A fragrance. SGTC_2033 5192550 145 µM -0.743991759138766 0.270707206726939 no 2466 0.228440730339557 3746 182073 SGTC_1781 st038725 66.3 µM -0.74404597753093 0.270691366266499 no 2467 0.228424330039707 3762 4270275 YIL048W NEO1 SGTC_1209 2323-2347 50.3 µM -0.745916660349352 0.270145110700775 no 2468 0.227858880191503 3702 5412760 SGTC_3307 9126885 69.2785 µM -0.747322495359254 0.269734957916801 no 2469 0.227434458400157 3749 24824909 SGTC_2683 piperine 63.03 µM -0.747975011574629 0.2695446921444 no 2470 0.227237615072799 3732 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_830 4076-0286 57.8 µM -0.750836731294271 0.268711044638309 no 2471 0.226375460338403 3806 6866659 SGTC_2335 9018011 154.17 µM -0.751849386118015 0.268416358780099 no 2472 0.226070819363468 3801 6458208 SGTC_1120 ficusin 1.78878 µM -0.752894314919855 0.268112451543003 no 2473 0.225756712337082 3864 6199 A DNA cross-linker. SGTC_413 propylparaben 100 µM -0.753064116563436 0.268063082772777 no 2474 0.225705693058641 3719 7175 A pharmaceutical preservative. SGTC_1584 6-fluoro-dl-tryptophan 90 µM -0.753748130039689 0.267864256472411 no 2475 0.225500237719075 3788 94937 An inhibitor of serotonin biosynthesis. SGTC_1513 0337-0559 19 µM -0.753799846058174 0.267849226888071 no 2476 0.225484708219352 3743 775073 SGTC_1557 sumaresinolic acid 42.3 µM -0.754983544904274 0.267505339361867 no 2477 0.225129427776785 3711 9982268 A natural terpine and antifungal of unknown mechanisn. SGTC_1872 amphotericin b 148 nM -0.756525302643303 0.267057762851311 no 2478 0.224667153918048 3783 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1 SGTC_2716 st080858 38.6235 µM -0.759561303027503 0.266177510427882 no 2479 0.223758428712808 3755 5296050 SGTC_2113 5491891 107.031 µM -0.760175384416377 0.265999643563836 no 2480 0.22357487836868 3787 789979 SGTC_1916 st067606 49.2 µM -0.76129861331852 0.265674459478836 no 2481 0.223239364323544 3785 19590279 SGTC_2566 crystal violet carbinol 226 nM -0.762669975249887 0.265277712296077 no 2482 0.222830120535575 3769 68050 Cationic dye that binds acidic phospholipids including cardiolipin. SGTC_1679 SEC14.276 6.7 µM -0.763018276343408 0.265176993616803 no 2483 0.222726248137784 3821 1005053 YMR079W SEC14 SGTC_591 4299-0174 154 µM -0.763424424887814 0.265059571644798 no 2484 0.222605158992222 3765 5509088 SGTC_16 erodoxin 22.806 µM -0.765930463032849 0.26433563346744 no 2485 0.221858839398483 3804 3967339 Erodoxin inhibits Ero1. YML130C ERO1 SGTC_2291 7917025 104.35 µM -0.768684416581448 0.263541240653332 no 2486 0.221040339072149 3739 2964612 SGTC_2407 paclitaxel 400 µM -0.770134221917856 0.263123526500941 no 2487 0.220610138883031 3968 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM -0.77137565258264 0.262766117762959 no 2488 0.220242151147766 3741 279621 SGTC_2337 9009472 200 µM -0.771383996169236 0.262763716479017 no 2489 0.220239679113944 3777 5742383 SGTC_1408 3909-7976 48.8 µM -0.771861269854363 0.262626375815683 no 2490 0.220098299183497 3847 24152374 SGTC_3326 9140064 16.379 µM -0.772331865076566 0.262490992926655 no 2491 0.219958948559476 3757 1868434 SGTC_1009 4106-0057 9.87 µM -0.77287561083005 0.262334610272891 no 2492 0.21979799997441 3774 2928005 SGTC_2499 avocadenofuran 51.48 µM -0.773170825975002 0.262249725640674 no 2493 0.219710644700398 3785 6857792 A insecticide and lysyl oxidase inhibitor. SGTC_1125 tnp00248 1.32998 µM -0.774397427458479 0.261897185755442 no 2494 0.219347902240038 3902 24207736 SGTC_1224 0823-0416 294 µM -0.776052858356698 0.261421780813052 no 2495 0.218858888285714 3858 3598164 SGTC_2181 6316240 54.2555 µM -0.776682893848427 0.261240964365666 no 2496 0.218672940841726 3804 12779990 SGTC_1336 1486-0901 104 µM -0.777008551194272 0.261147527837738 no 2497 0.218576862629643 3820 5006114 SGTC_943 3253-1379 105 µM -0.777309644905383 0.261061154310309 no 2498 0.21848805301809 3772 668464 SGTC_155 k072-0202 43.6 µM -0.778268742886236 0.260786119706789 no 2499 0.218205299183673 3724 5857737 SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM -0.780038207209105 0.260279092870097 no 2500 0.217684193179474 3810 688761 SGTC_3329 9141233 27.5565 µM -0.780427406740654 0.260167638826386 no 2501 0.217569670601114 3783 4909101 YNL103W MET4 SGTC_1298 1079-1278 263 µM -0.781368967777051 0.259898108252073 no 2502 0.217292758636656 3830 2840950 SGTC_2370 9071495 200 µM -0.782749228695577 0.259503256270018 no 2503 0.21688719367947 3812 21791103 SGTC_1551 6-bromo-3'-methylflavone 63.5 µM -0.783840270906364 0.259191360610843 no 2504 0.216566920348599 3814 688751 SGTC_1378 2093-0007 380 nM -0.784491194135175 0.259005373862179 no 2505 0.216375973479112 3877 3618014 SGTC_603 3794-0023 45.9 µM -0.784995648235165 0.258861284877344 no 2506 0.216228060044904 3794 3802260 SGTC_1851 st056236 18.9 µM -0.785658009395193 0.258672155347715 no 2507 0.216033934844873 3782 5393171 SGTC_2657 nystatin 74.44 µM -0.785994891527432 0.258575990022293 no 2508 0.215935239974512 3838 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_2736 butenafine 14.65 µM -0.787103691178309 0.258259606315608 no 2509 0.215610584394376 3780 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_2991 9074669 71.4286 µM -0.78853425346859 0.257851707831874 no 2510 0.215192135434077 3779 17333109 SGTC_1978 st071761 42 µM -0.788722924671108 0.257797936677874 no 2511 0.215136983061162 3835 5147680 SGTC_1041 0206-0046 107 µM -0.789073788959845 0.257697956090231 no 2512 0.215034440221099 3838 50494 SGTC_2621 lithochol-11-enic acid 100 µM -0.790580535746994 0.257268829779078 no 2513 0.214594404407532 3764 6708711 SGTC_2409 alverine citrate 63.97 µM -0.790948367142264 0.257164126655269 no 2514 0.214487061127466 4004 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_1855 st056195 39.6 µM -0.790989424331618 0.257152441110281 no 2515 0.214475081451711 3748 4028379 SGTC_2059 5238311 157 µM -0.792718445826966 0.256660584179758 no 2516 0.213970940441585 3831 703021 SGTC_2899 9053889 58.44 µM -0.793878540823461 0.256330845307873 no 2517 0.213633071737511 3742 6470052 SGTC_1487 3970-0795 2.82 µM -0.79441813037481 0.256177550677622 no 2518 0.213476026416383 3878 3765103 SGTC_365 0121-0052 13.6 µM -0.794539119476365 0.256143184855139 no 2519 0.213440822272642 3868 3101739 SGTC_3119 9125183 49.47 µM -0.796938256510626 0.255462229234059 no 2520 0.212743445567214 3670 22695334 SGTC_3058 9093861 49.47 µM -0.796940428085301 0.255461613297035 no 2521 0.212742814941105 3826 17217477 SGTC_1050 3232-1156 69.3 µM -0.797911893925055 0.255186148329389 no 2522 0.212460810359629 3816 700529 SGTC_262 fenpropimorph 62.5 µM -0.797981267092343 0.255166483095245 no 2523 0.212440680540624 3780 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_472 calcifediol 10 µM -0.798101362960946 0.255132441354162 no 2524 0.212405835290774 3867 5283731 A vitamin D metabolite. SGTC_869 0564-0080 44.1 µM -0.798299391951204 0.255076314289448 no 2525 0.212348385407051 3843 6843321 SGTC_855 0428-0020 25 µM -0.798349882276171 0.25506200492447 no 2526 0.212333739189906 3839 6812414 SGTC_109 0132-0036 33.701 µM -0.798560241225924 0.255002392022423 no 2527 0.212272724687553 3646 67274 A color developer. SGTC_20 0481-0013 4.944 µM -0.801050994913319 0.254297100387731 no 2528 0.211551062251356 3855 182045 SGTC_2640 pentamidine 10.38 µM -0.802445099225081 0.253902787162834 no 2529 0.21114776701506 3856 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_3014 9081533 49.47 µM -0.802987235173619 0.253749534283509 no 2530 0.210991056282609 3859 21367265 SGTC_1969 st069479 40.1 µM -0.803305904256477 0.253659474467034 no 2531 0.210898973087267 3832 3895485 SGTC_2522 biochanin a 4.94 µM -0.803415469945848 0.253628513729354 no 2532 0.210867318231989 3810 5280373 A possible chelator. SGTC_1541 2',3',6-trimethoxyflavone 64 µM -0.803822820380294 0.253513423298419 no 2533 0.210749654193481 3913 688801 SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM -0.806939214677116 0.252633844094338 no 2534 0.209850752235912 3805 7104 SGTC_1797 st048695 56.8 µM -0.807174222738652 0.252567580049913 no 2535 0.2097830573247 3804 592262 YIL048W NEO1 SGTC_2096 5468907 200 µM -0.808019203264718 0.252329400798108 no 2536 0.20953976375692 3886 759785 SGTC_2019 4016004 108 µM -0.808308387565536 0.252247914053089 no 2537 0.209456537631214 3866 45595336 SGTC_2878 9043973 25.97 µM -0.80966276363321 0.251866460876725 no 2538 0.209067012349928 3936 6465167 SGTC_5 0352-0601 109.883 µM -0.81104777358473 0.251476694951354 no 2539 0.208669118121407 3758 762456 SGTC_2230 bromochlorosalicylanilide 954.5 nM -0.811055738254727 0.251474454476595 no 2540 0.208666831273288 3842 77254 SGTC_1856 st057054 55.7 µM -0.813962729928671 0.250657417959842 no 2541 0.20783315117314 3841 1266018 SGTC_2034 5197015 53.07 µM -0.814394940732806 0.250536061346969 no 2542 0.207709368014028 3847 780676 SGTC_1559 coumarin 343 70.1 µM -0.81565075948785 0.250183627920374 no 2543 0.207349954579193 3843 108770 A hepatotoxic, DNA x-linker. SGTC_984 1492-0255 2.91 µM -0.816339286573193 0.24999051109084 no 2544 0.207153055328833 3835 1585198 SGTC_3116 9124943 49.47 µM -0.817284450737087 0.249725542035432 no 2545 0.206882945332238 3833 41905195 YPL160W CDC60 SGTC_761 k216-0224 480 µM -0.81820581700818 0.249467388149528 no 2546 0.206619837081102 3864 1340404 SGTC_3335 9143315 29.6265 µM -0.818539993408429 0.249373791675272 no 2547 0.206524457610992 3856 4899691 SGTC_941 3237-0776 460 µM -0.819380217826653 0.249138543237465 no 2548 0.206284758927162 3892 760008 SGTC_1184 1269-1718 139 µM -0.821116109286361 0.248652897477445 no 2549 0.205790067459363 3934 5403821 SGTC_904 1141-0088 396 µM -0.822303309205417 0.248321048266588 no 2550 0.205452146902558 3886 1378119 SGTC_665 3914-0008 307 µM -0.822370001429128 0.248302413289489 no 2551 0.205433173634589 3822 1069549 SGTC_3205 9113483 49.47 µM -0.822737546685652 0.248199728075909 no 2552 0.205328629369881 3938 17018033 SGTC_921 1561-0023 372 µM -0.823826481300586 0.247895633266661 no 2553 0.205019079288353 3837 24050882 SGTC_2573 2',4'-dihydroxychalcone 15.04 µM -0.824217433638638 0.247786504834931 no 2554 0.20490801146604 3870 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_2782 7736369 71.43 µM -0.82466978796281 0.247660268982145 no 2555 0.20477954426767 3925 2950836 YOL077C BRX1 SGTC_83 0170-0301 39.027 µM -0.824984905929459 0.247572351171965 no 2556 0.204690080075713 3793 3089716 SGTC_2935 9038016 29.96 µM -0.825061362483939 0.247551022331842 no 2557 0.204668377031329 3885 6463195 SGTC_2506 ethyl hematommate 54.16 µM -0.825146756625444 0.247527201362273 no 2558 0.204644138571762 3955 3940691 An allergen. SGTC_2597 laccaic acid a 100 µM -0.82516291957746 0.247522692792827 no 2559 0.204639551036389 3887 5491415 A textile dye. SGTC_2399 5884133 200 µM -0.825243918405021 0.247500099261866 no 2560 0.204616562037201 3886 722445 SGTC_1317 1273-0028 910 nM -0.825548354596667 0.24741519074546 no 2561 0.204530171029882 3855 5917803 YLR359W | YHR072W ADE13 | ERG7 SGTC_2067 5224629 34.075 µM -0.826542405256348 0.247138054334778 no 2562 0.204248236708841 3861 2835000 SGTC_3236 9132701 49.47 µM -0.826813102203668 0.247062614137177 no 2563 0.204171501294202 3867 24282524 SGTC_1582 3',3',6'-trihydroxyflavone 74 µM -0.827019097779425 0.24700521374038 no 2564 0.204113118510912 3841 688803 SGTC_1968 st069590 43.6 µM -0.830773148396175 0.245960403499075 no 2565 0.203050897177377 3875 6384066 SGTC_2320 7373003 200 µM -0.832347836329789 0.24552285056117 no 2566 0.20260631833921 3949 5415828 SGTC_1982 st072467 71.9 µM -0.833005663604269 0.245340186345694 no 2567 0.202420767562707 3861 3163533 SGTC_725 1497-0963 19 µM -0.837214024493685 0.244173347103065 no 2568 0.20123613784394 3934 3549977 SGTC_92 0063-0024 660.874 µM -0.837866061823428 0.24399282682931 no 2569 0.201052965658584 3971 3594437 SGTC_369 0957-0393 4.5 µM -0.838122730063442 0.243921786508915 no 2570 0.200980889125192 3914 6997992 SGTC_40 0327-0103 19.753 µM -0.840268744331091 0.243328252306014 no 2571 0.200378860954712 3773 409036 SGTC_3175 9106517 49.47 µM -0.843936747915387 0.242315583472314 no 2572 0.199352375982231 3933 41468073 SGTC_934 2950-0684 338 µM -0.844647530217554 0.242119613953243 no 2573 0.199153831523162 3960 1121253 SGTC_488 nitrendipine 139 µM -0.845393368166209 0.241914071683651 no 2574 0.19894562301306 3934 4507 Dihydropyridine L-type calcium channel blocker. SGTC_2151 5563267 85.4165 µM -0.848503292560917 0.241058042180799 no 2575 0.198078869783842 3923 5310824 SGTC_2766 oltipraz 83.91 µM -0.851267151233386 0.240298654278992 no 2576 0.197310483957332 3849 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40 SGTC_2642 cholecalciferol 100 µM -0.85494256324985 0.239290833644814 no 2577 0.196291472900799 3890 9821465 A vitamin D precursor, similar to steriods. SGTC_1788 fluconazole 20 µM -0.856385603778046 0.238895775235073 no 2578 0.195892262508826 3963 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11 SGTC_1377 2944-0135 198 µM -0.857881219372165 0.238486700154326 no 2579 0.19547902778538 3965 1894137 SGTC_2238 6671620 73.2395 µM -0.858683386228021 0.238267452633142 no 2580 0.195257609448332 3865 729941 SGTC_1725 st036284 20.55 µM -0.861390060509416 0.237528482327863 no 2581 0.194511624247215 4024 707914 SGTC_920 mycophenolic acid 780.421 nM -0.862661949463365 0.237181668894901 no 2582 0.194161679431531 3947 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_865 0488-0499 301 µM -0.863204793712942 0.23703373310882 no 2583 0.194012439258561 3900 9634651 SGTC_2355 9061122 103.12 µM -0.864083324820461 0.236794423498936 no 2584 0.193771059309326 3947 5302957 SGTC_646 4092-0839 27.3 µM -0.864710050540648 0.236623786259108 no 2585 0.193598975840516 3969 877796 SGTC_3025 9087895 49.47 µM -0.865379583961284 0.236441568623665 no 2586 0.193415241433108 3938 17173641 SGTC_1210 3013-0140 750 nM -0.866125015761752 0.236238785675654 no 2587 0.193210804079943 3960 905973 SGTC_1266 0828-0227 32.9 µM -0.866716762321616 0.236077878587985 no 2588 0.193048609403604 3951 3913820 SGTC_1206 3978-0017 132 µM -0.866724295854211 0.23607583046724 no 2589 0.193046545037316 4038 3873677 SGTC_3312 9133330 71.43 µM -0.867133171646719 0.235964685217794 no 2590 0.192934523609309 3975 17617324 SGTC_2921 7974240 10.71 µM -0.868083531749009 0.235706459018518 no 2591 0.192674302861888 4009 2979074 YDR527W RBA50 SGTC_3161 9100388 49.47 µM -0.871226155613554 0.234853674669868 no 2592 0.191815340634233 3981 25236368 SGTC_3289 9119912 71.43 µM -0.871514527299948 0.234775507462271 no 2593 0.191736638635199 3965 17014829 SGTC_356 1634-0012 32.5 µM -0.873488307705229 0.234240872781638 no 2594 0.19119848825589 3916 735457 SGTC_2993 9054257 71.4286 µM -0.873639235572006 0.234200018953657 no 2595 0.191157375984363 3886 6470217 YGL055W OLE1 SGTC_1938 st074717 56.4 µM -0.873927310208835 0.23412205257811 no 2596 0.19107892041539 3766 17250979 SGTC_2854 9024559 71.43 µM -0.874841236398964 0.233874796862793 no 2597 0.190830148283797 3992 3163529 SGTC_1692 fluoroquinolonic acid 71 µM -0.874983068840903 0.233836438158375 no 2598 0.190791559093091 3989 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2 SGTC_192 3455-0609 60.9 µM -0.876511343756437 0.233423336165096 no 2599 0.19037605613587 4003 3769639 SGTC_1758 st042942 75.2445 µM -0.877184431869895 0.233241524860406 no 2600 0.190193235306142 3857 669317 SGTC_659 k018-0002 107 µM -0.881343216714204 0.23211991883137 no 2601 0.18906604081566 3946 6797879 YHR007C ERG11 SGTC_3064 1327-0027 10 µM -0.88152289714533 0.232071527557944 no 2602 0.189017433247611 3839 16000455 YPR107C YTH1 SGTC_1033 k072-0102 21.3 µM -0.88192618665881 0.231962934661876 no 2603 0.188908362461954 3924 5965931 SGTC_1404 3909-7820 48.3 µM -0.8866794295035 0.230685173452388 no 2604 0.187625758158956 3897 23741373 SGTC_717 1532-0246 73.2 µM -0.886754652931392 0.230664983635325 no 2605 0.18760550338261 3954 9561992 SGTC_348 k064-0012 10.7 µM -0.887652403921492 0.230424105283668 no 2606 0.187363877849182 3854 5066323 SGTC_3129 9127257 49.47 µM -0.889891021109267 0.229824067918853 no 2607 0.186762202825498 3950 837894 SGTC_2338 7999974 200 µM -0.890267344312372 0.229723284478826 no 2608 0.186661175670031 3980 315925 SGTC_1993 st073995 70.8 µM -0.890679487426089 0.229612936480894 no 2609 0.186550571182181 3940 3098394 SGTC_450 aminopyrene 156 nM -0.890808688549436 0.229578350035423 no 2610 0.186515906573718 3862 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1 SGTC_1519 esterone 74 µM -0.891259947056684 0.229457573463723 no 2611 0.186394865402056 3937 698 A steroid. SGTC_1045 1348-1485 165 µM -0.891273692278285 0.229453895198372 no 2612 0.186391179281966 3962 6810614 SGTC_1208 2323-2347 50.3 µM -0.891418426634296 0.229415165826823 no 2613 0.186352367936902 3970 5412760 SGTC_757 1066-0008 322 µM -0.891693118486076 0.229341671290649 no 2614 0.186278721515773 3991 6842497 SGTC_1859 st055998 20 µM -0.893869931978987 0.228759725992137 no 2615 0.185695743552503 3899 676301 SGTC_301 4119-0100 24.5 µM -0.894727929054809 0.228530578613083 no 2616 0.185466272505787 3985 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1 SGTC_1226 3909-7979 35.4 µM -0.8947416067574 0.228526926719986 no 2617 0.185462615834412 3988 6615510 SGTC_1414 3917-0015 5.4 µM -0.894825394463384 0.228504556445684 no 2618 0.185440216550272 3902 6618702 SGTC_551 k048-0028 34.9 µM -0.89502813103394 0.228450433395228 no 2619 0.185386025164298 3962 6836383 SGTC_439 amiodarone 34.4 µM -0.895795711699849 0.228245583455106 no 2620 0.185180940316836 3836 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1 SGTC_1067 clotrimazole 1.36 µM -0.896004274147751 0.228189940694351 no 2621 0.185125240237321 3971 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_720 r052-1644 49.9 µM -0.896158899515309 0.228148692830351 no 2622 0.185083951672975 3987 1422863 YOR257W CDC31 SGTC_2301 7769476 200 µM -0.899381348253701 0.227290027063625 no 2623 0.184224785276737 4007 977820 SGTC_502 l-744,832 89.3 µM -0.901092282853241 0.226834866147862 no 2624 0.183769627859409 3970 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.  SGTC_820 1582-0060 59.9 µM -0.901187422630087 0.226809571158817 no 2625 0.18374433854136 4004 3848840 SGTC_1251 0490-5699 265 µM -0.901877874373407 0.226626047160596 no 2626 0.183560872977178 4027 3883818 SGTC_2781 5567276 71.43 µM -0.90226357083579 0.226523564465078 no 2627 0.183458436142192 4023 2853274 SGTC_2145 5634607 200 µM -0.902889892295698 0.226357201499944 no 2628 0.183292167827153 3937 308662 SGTC_1098 clofazimine 15.1 µM -0.903849577408926 0.226102424698394 no 2629 0.183037584488067 4040 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2 SGTC_3334 9142812 21.919 µM -0.904456528627905 0.225941375243309 no 2630 0.18287668763169 4001 45283678 SGTC_701 4424-0219 185 µM -0.905298015514364 0.225718201032539 no 2631 0.182653763732792 4032 2911779 SGTC_990 3985-0011 41.3 µM -0.906345484011483 0.225440571900789 no 2632 0.182376509050504 3970 5399565 YGL099W LSG1 SGTC_2309 7664088 163.95 µM -0.908581942810754 0.224848451079173 no 2633 0.181785420856227 3994 704922 SGTC_959 1222-0044 107 µM -0.90924520165652 0.224673017521839 no 2634 0.181610354539889 3961 6083612 SGTC_1730 st033808 45.1 µM -0.909879974897068 0.224505191205665 no 2635 0.181442905804588 3937 1045166 SGTC_1079 idarubicin 2.36 µM -0.910991738036552 0.224211426032281 no 2636 0.181149863441737 3988 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_774 k060-0086 136 µM -0.91179101891116 0.224000364110714 no 2637 0.180939369524372 3938 5911235 SGTC_2128 5255449 168.493 µM -0.912483767905446 0.223817524855481 no 2638 0.180757055267682 3980 736008 SGTC_212 3807-4682 38.772 µM -0.918209723391921 0.222309508864171 no 2639 0.179254539554159 4066 3125501 YBL034C STU1 SGTC_1156 4092-0367 4.88 µM -0.918892660495109 0.222130034896619 no 2640 0.179075859627872 4002 1357585 SGTC_822 1487-0950 154 µM -0.919041636617051 0.222090895377436 no 2641 0.179036897223362 4016 1958375 SGTC_2820 7989630 71.43 µM -0.920466508297772 0.221716747126365 no 2642 0.178664513544741 3959 2984098 SGTC_1996 st072960 66.8 µM -0.922244594229982 0.221250356018942 no 2643 0.178200503515517 4025 1719405 SGTC_1892 st058411 7.36 µM -0.922350268286883 0.221222655441211 no 2644 0.178172950703147 4013 3934738 SGTC_931 2812-0076 566 µM -0.923976217681037 0.22079669184791 no 2645 0.177749349086302 3975 3450959 SGTC_2602 kawain 100 µM -0.925392470601318 0.220426047215624 no 2646 0.177380896970052 3994 5369129 SGTC_2065 5221596 34.26 µM -0.926552855912879 0.220122631135879 no 2647 0.177079370994658 4004 788581 SGTC_1354 1498-1681 81 µM -0.926646106894082 0.22009825839104 no 2648 0.177055153803776 4015 5754243 SGTC_749 1000-0129 128 µM -0.927373850523655 0.219908103286698 no 2649 0.176866231367193 4066 708470 SGTC_1533 dihydroergotamine mesylate 29.4 µM -0.928832425242095 0.21952727031816 no 2650 0.176487968732598 4093 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release. SGTC_977 1348-1378 135 µM -0.932226414430755 0.218642569689575 no 2651 0.17560976363545 4004 X977 SGTC_3131 9127911 49.47 µM -0.933972470074041 0.218188231477638 no 2652 0.175159047030904 4061 45595681 SGTC_608 k048-0125 159 µM -0.934005669100476 0.218179598088649 no 2653 0.175150484342326 4060 6817652 YLR060W | YFL022C FRS1 | FRS2 SGTC_2575 plumbagin 510 nM -0.934289721578253 0.218105738442893 no 2654 0.175077232418601 3927 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_462 ag-879 158 µM -0.935084137560869 0.217899250034199 no 2655 0.174872470308465 4035 6809654 Ag-879 is a 5-Lipoxygenase inhibitor. SGTC_536 3852-0578 10.6 µM -0.937071059375472 0.217383293669633 no 2656 0.174361003493926 4075 2869208 SGTC_1059 3448-6867 171 µM -0.939249509889747 0.216818413376795 no 2657 0.17380132739979 3931 3934407 SGTC_2486 5283202 22.39 µM -0.942288958263758 0.21603169300907 no 2658 0.173022359865652 4073 1377751 SGTC_503 tyrphostin 8 294 µM -0.94259989847832 0.215951303654452 no 2659 0.172942795893946 4018 92970 A tyrosine kinase inhibitor. YOR207C RET1 SGTC_2221 6807166 181.081 µM -0.942681113974309 0.215930309349918 no 2660 0.172922018159147 3956 674925 SGTC_1634 st006576 41 µM -0.944846014449004 0.215371116002373 no 2661 0.172368748074029 4030 3915356 SGTC_1452 4194-0072 190 µM -0.94605330784196 0.21505963763715 no 2662 0.17206069866248 4095 1343545 SGTC_1004 4084-0029 199 µM -0.946979757565653 0.214820793630474 no 2663 0.171824546944984 4052 716894 YLR208W SEC13 SGTC_999 SEC7.066 22.7 µM -0.949109330410249 0.214272362245466 no 2664 0.171282504714121 4011 740511 YDR170C SEC7 SGTC_1899 st063254 59.6 µM -0.949620521974949 0.214140835806596 no 2665 0.171152553515322 3979 3093813 SGTC_495 decylubiquinone 155 µM -0.950609864917614 0.213886417452514 no 2666 0.17090122948829 4081 2971 A Co-enzyme Q analog. A free radical scavenger. SGTC_1903 st060211 78.3 µM -0.951097155801926 0.21376117097751 no 2667 0.170777529212375 4077 688960 SGTC_1954 st077032 68.9 µM -0.951354106694799 0.213695145096092 no 2668 0.170712324525294 4013 698907 SGTC_1040 k898-0338 155 µM -0.953197427794397 0.21322183530241 no 2669 0.170245024710094 4051 20969351 SGTC_2792 7535235 81.82 µM -0.953437367321497 0.213160270998976 no 2670 0.170184258045585 4041 1281891 SGTC_1483 3453-0561 55.9 µM -0.953532106758416 0.213135965364907 no 2671 0.170160268329335 4045 4546991 SGTC_378 3970-0959 8.33 µM -0.954086571827366 0.212993748415429 no 2672 0.170019911333528 4066 6615653 SGTC_3048 9093155 49.47 µM -0.954992873118561 0.212761406853054 no 2673 0.169790650532509 3991 25236002 SGTC_2647 atorvastatin 60.16 µM -0.955547194102175 0.212619372757089 no 2674 0.16965052552165 4009 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7 SGTC_2340 7987427 183.45 µM -0.956791889649068 0.21230064529191 no 2675 0.169336153331412 4067 2239331 SGTC_2611 pyromycin 23.93 µM -0.957064812798247 0.212230795584223 no 2676 0.169267271270324 4024 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release. SGTC_31 0508-1974 57.237 µM -0.959596456874044 0.211583507929553 no 2677 0.168629176480836 3974 6810525 SGTC_2981 9013952 38.96 µM -0.960360527687511 0.211388378516919 no 2678 0.168436898414837 4019 2996344 SGTC_2027 5150920 200 µM -0.96091276973365 0.211247411856166 no 2679 0.168298014766546 3985 786715 SGTC_3296 9122258 64.045 µM -0.961418522229371 0.211118360562196 no 2680 0.168170887437234 4047 4730474 SGTC_2839 9003951 25.97 µM -0.961639838222911 0.21106190258368 no 2681 0.168115276282841 4101 2990634 SGTC_2369 9071472 200 µM -0.962119361778633 0.210939605907118 no 2682 0.167994824647928 4116 17296037 SGTC_152 4469-0003 551.229 µM -0.962353534840496 0.210879898005358 no 2683 0.167936022851966 3952 697280 SGTC_2403 6032726 181.2 µM -0.963319909960662 0.210633602915146 no 2684 0.167693502345647 4113 2881040 SGTC_124 0136-0217 7.121 µM -0.963427205643093 0.210606267426513 no 2685 0.167666589449797 4087 3976905 SGTC_1214 0358-0031 63.7 µM -0.966290100146976 0.209877663066494 no 2686 0.166949519216997 4193 4301366 SGTC_2466 5983409 37.09 µM -0.967808872700699 0.209491738892569 no 2687 0.166569915877868 4069 2879657 SGTC_2150 5556613 200 µM -0.971336501242618 0.208596971631163 no 2688 0.165690368914045 4045 743190 SGTC_944 3370-0224 231 µM -0.973529506426099 0.208041863104629 no 2689 0.165145101362488 4102 4580514 SGTC_2959 9079155 11 µM -0.973548319418536 0.208037104806303 no 2690 0.165140428741388 4115 16189457 SGTC_1920 st075728 45.7 µM -0.973755246852505 0.207984771680291 no 2691 0.165089039402282 4012 3400306 SGTC_1850 st056238 17 µM -0.973900420607955 0.207948061050581 no 2692 0.165052992444175 4068 5393177 SGTC_1661 st013063 9.66 µM -0.977012272361194 0.207162075788971 no 2693 0.164281538362095 4111 721395 SGTC_1760 st045453 10.4495 µM -0.977158936427195 0.207125075086787 no 2694 0.164245236899444 4129 3323419 YIL048W NEO1 SGTC_1435 4092-0789 56.7 µM -0.977781953642529 0.206967942645114 no 2695 0.164091089176585 4052 2248285 SGTC_2265 7929201 200 µM -0.978110640156189 0.206885072382338 no 2696 0.16400980296221 4025 1265108 SGTC_414 piperonyl butoxide 100 µM -0.978229819259335 0.206855029139514 no 2697 0.163980335685084 4053 5794 A potent inhibitor of cytochrome P450. SGTC_2547 epiafzelechin trimethyl ether 100 µM -0.978567720493063 0.206769863409175 no 2698 0.163896807590694 3918 6708630 An antioxidant. SGTC_1012 4112-3522 18 µM -0.978935848047119 0.206677102970061 no 2699 0.163805839078086 4084 3112398 SGTC_1418 3966-3099 2.4 µM -0.979070196320194 0.206643256155548 no 2700 0.163772648252861 4067 740335 SGTC_2231 micatex 6.853 µM -0.979868338091141 0.206442245289197 no 2701 0.163575556832761 4081 20737 An antifungal of unknown mechanism. SGTC_2361 9034121 116 µM -0.980463785067277 0.206292358299381 no 2702 0.163428618784727 4056 6496917 SGTC_1078 idebenone 36.1 µM -0.98141099906492 0.206054056832945 no 2703 0.163195052146781 4118 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen. SGTC_1935 st074532 41.6 µM -0.985794498071378 0.20495337742415 no 2704 0.162116983098494 4065 2829742 SGTC_3162 9099653 49.47 µM -0.986582953325272 0.204755770958793 no 2705 0.161923565220135 4056 25237511 SGTC_837 0091-0265 12.5 µM -0.987006680956223 0.204649621122937 no 2706 0.161819681694053 4021 759367 SGTC_2587 piperic acid 92.2 µM -0.987746980200789 0.204464244152136 no 2707 0.161638289872331 4075 5370536 SGTC_755 1995-0008 37.3 µM -0.989781891011205 0.203955201073235 no 2708 0.161140368998011 4034 689533 SGTC_3160 9100216 49.47 µM -0.990841887144753 0.203690337168424 no 2709 0.160881396159245 4000 17191039 SGTC_1962 st076595 64.5 µM -0.991008097476011 0.203648824381915 no 2710 0.160840813156041 4067 279619 SGTC_2215 7188065 200 µM -0.991476997645769 0.203531738804545 no 2711 0.160726359446162 4094 940217 SGTC_3006 9075424 71.4286 µM -0.99178027223754 0.203456031746709 no 2712 0.160652361567172 4028 7465181 SGTC_2149 5554786 194.827 µM -0.99278193556396 0.203206103875809 no 2713 0.160408117550183 4099 745063 YPR165W RHO1 SGTC_2658 polymyxin b sulfate 77.05 µM -0.993151093393841 0.203114040487405 no 2714 0.160318163904191 4106 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides.  YIL048W NEO1 SGTC_3133 9127736 49.47 µM -0.996907674019937 0.202178612613192 no 2715 0.15940466320756 4079 27243420 SGTC_2344 7990960 76.95 µM -0.997750494764513 0.201969095983198 no 2716 0.15920018056164 4060 140813 SGTC_1356 1502-0781 85.8 µM -0.998071981628299 0.201889211885475 no 2717 0.159122227666889 4072 567702 SGTC_1499 4480-0877 67.3 µM -0.9990321682113 0.201650734255125 no 2718 0.158889554217356 4014 2861909 SGTC_772 k072-0172 35.3 µM -0.999463844172802 0.201543575660463 no 2719 0.158785022724241 4127 5861980 SGTC_2122 5258151 111.688 µM -1.00146622135444 0.201046954903986 no 2720 0.158300731382869 4083 2173356 SGTC_181 1447-1644 8.07 µM -1.00187168190007 0.200946483804082 no 2721 0.15820278554087 4103 534600 SGTC_396 dithiazanine 1.25 µM -1.00608844044954 0.199903378838597 no 2722 0.157186514376368 4088 10578 An antihelmenthic. SGTC_2284 7945075 39.21 µM -1.00729678208312 0.199605071125965 no 2723 0.156896087854191 4101 1245402 SGTC_861 0443-0273 110 µM -1.00820199775709 0.199381772833955 no 2724 0.156678749520675 4094 6149169 SGTC_3271 9137798 49.47 µM -1.00975030679263 0.199000185299515 no 2725 0.156307466845473 4035 6498326 SGTC_506 n9-isopropylolomoucine 153 µM -1.01479648273634 0.197759590931097 no 2726 0.155101425359099 4121 6610355 SGTC_2020 4017018 200 µM -1.01529198817398 0.197638024198523 no 2727 0.154983331184628 4181 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope. SGTC_1183 1254-0324 198 µM -1.01720782618143 0.197168419813737 no 2728 0.154527286889797 4188 5799357 SGTC_897 1000-0139 31.4 µM -1.01723935335307 0.197160697620116 no 2729 0.15451978961708 4058 6151020 SGTC_2117 5521686 200 µM -1.02167373015541 0.196076375278665 no 2730 0.153467674256618 4063 803312 SGTC_469 w7 172 µM -1.02168325660514 0.196074049710353 no 2731 0.15346541909846 4185 45115570 A P450 inhibitor. SGTC_1148 3909-7663 27.7 µM -1.02348691084701 0.195634048535723 no 2732 0.153038842748278 4148 4084526 SGTC_1606 st000094 49.2 µM -1.02549690950558 0.195144416574308 no 2733 0.152564391451421 4150 1242210 SGTC_448 monastrol 171 µM -1.02683194958894 0.194819615296779 no 2734 0.152249801091482 4030 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity SGTC_2255 7941087 197.44 µM -1.02786660149761 0.194568121615726 no 2735 0.152006290964407 4222 935561 SGTC_1874 staurosporine 7.6 µM -1.03147989415262 0.193691386544976 no 2736 0.151157915986197 4165 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1 SGTC_2262 9014885 67.46 µM -1.03380263746563 0.193129066461663 no 2737 0.150614219197149 4079 6457424 SGTC_2038 4100038 30.985 µM -1.03554311860243 0.19270836192386 no 2738 0.150207670237851 4115 3596803 SGTC_3100 9120536 49.47 µM -1.03573959527727 0.192660905298454 no 2739 0.150161822370777 3952 16421196 SGTC_1476 4112-3294 3.34 µM -1.03615497914417 0.192560597733982 no 2740 0.150064923181761 4145 704369 SGTC_930 2810-3379 265 µM -1.03653310096516 0.19246931602909 no 2741 0.149976752596759 4168 1015764 SGTC_2607 solasodine 47.35 µM -1.03690917563128 0.192378554769402 no 2742 0.149889093638441 4112 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity. SGTC_1445 4239-0156 97.7 µM -1.0373245983623 0.192278327738572 no 2743 0.149792302796723 4209 4008346 SGTC_2687 chenodiol 100 µM -1.03814895962854 0.192079532679737 no 2744 0.149600355368833 4222 5702181 A cholesterol synthesis inhibitor. SGTC_948 3448-0295 75.3 µM -1.03835841140074 0.192029043341955 no 2745 0.149551611977896 4121 678569 SGTC_2412 st077135 33.4 µM -1.03848931959786 0.191997491428161 no 2746 0.149521152545989 4226 13258915 SGTC_1457 k015-0032 57.3 µM -1.03952555884479 0.191747845694011 no 2747 0.149280188780753 4127 4302660 SGTC_2384 9036245 200 µM -1.03987479404636 0.191663754445595 no 2748 0.149199037192633 4066 6462766 SGTC_1815 st051655 58.2 µM -1.04143581935804 0.19128815623996 no 2749 0.148836662812394 4093 5984156 SGTC_3202 9113761 49.47 µM -1.04434688566873 0.190588930959452 no 2750 0.148162464004919 4132 4798415 SGTC_425 3825-7017 13.1 µM -1.0461936267644 0.190146166395375 no 2751 0.147735822403237 4192 3397440 SGTC_2373 9071805 200 µM -1.04714792581687 0.189917616762454 no 2752 0.147515679101032 4154 10149009 SGTC_2299 7976368 114.88 µM -1.04864064815781 0.189560456435364 no 2753 0.147171770109155 4175 2979718 SGTC_1808 st050063 61.5 µM -1.04884877107798 0.189510692177263 no 2754 0.14712386330222 4134 4011993 SGTC_1511 0906-3109 28.5 µM -1.0498274524687 0.189276787530553 no 2755 0.146898725564987 4154 2882180 SGTC_65 0798-0905 34.986 µM -1.05419319694384 0.188235541872013 no 2756 0.145897237037984 4259 3602145 SGTC_1422 4031-0024 15.5 µM -1.05762341282888 0.187419907634842 no 2757 0.145113582073305 4076 782427 SGTC_2685 mycophenolic acid 18.85 µM -1.06107018624808 0.186602540351605 no 2758 0.144329002861575 4125 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_2241 6772625 37.8075 µM -1.0613564739363 0.186534749558553 no 2759 0.144263964855405 4003 2285411 SGTC_2844 9010103 25.97 µM -1.06183598203879 0.186421239780472 no 2760 0.144155075858714 4175 2480525 SGTC_759 3486-0358 89.3 µM -1.06572425388552 0.185502383910408 no 2761 0.143274155200948 4157 875103 SGTC_1522 st012842 45.6 µM -1.06645742047204 0.185329441359408 no 2762 0.143108458406937 4007 3491067 YOR116C RPO31 SGTC_1694 st024011 44.9 µM -1.06646982508461 0.185326516166427 no 2763 0.143105656059259 4187 2787533 SGTC_2831 7999036 19.48 µM -1.06676686233218 0.18525647890748 no 2764 0.14303856292851 4196 2988270 SGTC_553 k007-0256 45.7 µM -1.06771401433133 0.185033263398089 no 2765 0.142824767421884 4210 6287000 SGTC_2022 5136654 200 µM -1.06872135862097 0.184796045801743 no 2766 0.142597622169643 4204 1713771 SGTC_187 1488-2104 32.728 µM -1.07345905323836 0.18368291215308 no 2767 0.141532600506827 4180 2852859 SGTC_978 1416-0512 87.4 µM -1.07410491562754 0.183531489340098 no 2768 0.141387830828289 4250 6814003 SGTC_2341 7987486 176.74 µM -1.07513020059377 0.183291270520019 no 2769 0.141158219984073 4204 1258686 SGTC_1754 st042065 16.137 µM -1.07578802557635 0.183137248922059 no 2770 0.141011034405522 3970 1126236 YIL048W NEO1 SGTC_2021 4019055 173 µM -1.07624438838275 0.183030444651745 no 2771 0.140908986317787 4029 44827708 YER133W GLC7 SGTC_190 3970-0790 3.722 µM -1.07724656374838 0.182796038267152 no 2772 0.1406850639666 4087 2832352 SGTC_1100 amiodarone 5.07 µM -1.07868823624529 0.182459163425946 no 2773 0.140363365779811 4265 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. SGTC_2066 5222451 176 µM -1.07942993994746 0.182286001101983 no 2774 0.140198055027006 4137 2281147 SGTC_2102 5377816 72.7585 µM -1.07958187786562 0.182250541497315 no 2775 0.140164207465195 4218 1379702 SGTC_1185 1319-0113 81.3 µM -1.08113807474687 0.181887601083779 no 2776 0.139817849482742 4234 4672763 SGTC_57 miconazole 162.5 nM -1.0822155264182 0.181636579939923 no 2777 0.139578385482612 4056 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_784 4579-0127 173 µM -1.08224516664324 0.181629677523102 no 2778 0.139571801876755 4220 1948547 SGTC_3106 9121286 49.47 µM -1.0838402503934 0.181258467235772 no 2779 0.139217817686203 4166 15943471 SGTC_2004 4023728 41.89 µM -1.08552952304469 0.180865855602041 no 2780 0.138843597571054 4150 360084 YDR527W RBA50 SGTC_1281 0884-0031 11.8 µM -1.08553955632981 0.180863525313507 no 2781 0.138841376972172 4192 1548255 SGTC_3199 9111318 49.47 µM -1.08635816375904 0.180673462405861 no 2782 0.138660281629434 4116 8548020 SGTC_2170 morpholine 200 µM -1.08719226975378 0.180479929933914 no 2783 0.138475923214072 4223 121171 Reacts with secondary amines. SGTC_402 epigallocatechin gallate 10 µM -1.08823611289542 0.180237916720028 no 2784 0.13824544302669 4121 65064 An antioxidant. SGTC_1560 lithocholic acid 53.1 µM -1.08825413245041 0.180233740706722 no 2785 0.138241466613121 4085 9903 A bile acid which acts as a detergent. SGTC_1795 st049545 62.3 µM -1.08833176049103 0.180215751182579 no 2786 0.138224337159629 4135 5291882 SGTC_324 1315-0088 19.6 µM -1.08878826990349 0.180109982481359 no 2787 0.138123632775669 4145 6787421 SGTC_3073 9114972 49.47 µM -1.09036498886155 0.179744972160145 no 2788 0.13777619894602 4184 41905075 SGTC_1563 conessine 56.1 µM -1.091969783749 0.179373939848012 no 2789 0.137423191346108 4268 441082 An anti-amoebic, histamine inhibitor. SGTC_1014 4130-3005 69.3 µM -1.09395929937284 0.178914628280767 no 2790 0.136986414577623 4195 743608 SGTC_2105 5350118 200 µM -1.09569962088282 0.178513454668861 no 2791 0.136605124337782 4158 2133313 SGTC_1889 st059080 5.18 µM -1.09594557452372 0.178456803915332 no 2792 0.136551296489946 4153 176925 Isolated from Daphnopsis sellowiana. SGTC_258 haloperidol 50.781 µM -1.09672734202821 0.178276813825147 no 2793 0.136380300168446 4175 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_1168 k815-0004 80.5 µM -1.09794896465071 0.177995782926946 no 2794 0.136113387574695 4165 642433 SGTC_3240 9133527 49.47 µM -1.09941061222031 0.177659902233625 no 2795 0.135794501981238 4142 17617455 SGTC_1942 st076330 65.2 µM -1.1003307628117 0.177448660623504 no 2796 0.135594016656145 4273 24208414 SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM -1.1010880540242 0.177274926104831 no 2797 0.135429167847385 4205 5379071 SGTC_166 k072-0058 166.424 µM -1.10172571840255 0.177128719198209 no 2798 0.135290466228639 4097 5846229 SGTC_272 doxorubicin 8.13 µM -1.10400757850616 0.17660614702702 no 2799 0.134794925119227 4191 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_2915 7971052 15.16 µM -1.10455832630402 0.176480165656372 no 2800 0.134675508541016 4107 5741558 SGTC_1044 1222-0021 1.78 µM -1.10463703455927 0.176462166099246 no 2801 0.134658448456533 4151 4306703 SGTC_2350 9023895 38.85 µM -1.10511623747397 0.176352603667331 no 2802 0.134554612801651 4209 2997209 SGTC_1770 st043884 66.3 µM -1.10657420383497 0.176019526664934 no 2803 0.134239032711652 4196 670149 SGTC_2583 asiatic acid 100 µM -1.10674135097206 0.175981366840668 no 2804 0.134202885846253 4245 5320556 A kinase inhibitor; arrests cells at G2/M. SGTC_2375 9072683 200 µM -1.10988834750087 0.175263882983526 no 2805 0.133523571175688 4278 16798029 SGTC_1259 0671-0132 43 µM -1.11445136416466 0.174226860509771 no 2806 0.132542799181149 4136 X1259 SGTC_2767 sibutramine 71.45 µM -1.11529850291443 0.174034763977 no 2807 0.132361263375642 4236 64765 A serotonin-norepinephrine reuptake inhibitor.  SGTC_1412 3909-8563 178 µM -1.11571365758339 0.173940673004543 no 2808 0.132272361280638 4282 23767530 SGTC_1682 st012968 530 nM -1.11576009792269 0.173930149742358 no 2809 0.132262419008898 4230 24207270 SGTC_1264 0783-0040 158 µM -1.11758324223624 0.173517349832576 no 2810 0.131872514591368 4099 2855798 SGTC_2089 5281248 129.67 µM -1.11929360604962 0.17313065324338 no 2811 0.131507451341342 4197 2737878 SGTC_840 0245-0196 390 µM -1.11948126702529 0.173088258366893 no 2812 0.131467439143063 4293 3827528 SGTC_2220 6782180 200 µM -1.11990324591465 0.172992952404135 no 2813 0.131377497470137 4136 833803 SGTC_1427 4048-4900 550 nM -1.12225571633301 0.172462248536403 no 2814 0.130876864508373 4201 24132586 SGTC_1074 carmofur 3.8 µM -1.12272417625955 0.172356690764924 no 2815 0.130777328428348 4242 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_815 1582-0027 36.9 µM -1.12956708151265 0.170819483508615 no 2816 0.129329344220959 4258 3128206 SGTC_1075 aripiprazole 15.2 µM -1.1298291400314 0.170760788990136 no 2817 0.129274113441892 4284 60795 An atypical antipschotic. YIL048W NEO1 SGTC_743 1275-0778 158 µM -1.13115815166275 0.170463322553131 no 2818 0.12899426606942 4203 2849257 YMR203W TOM40 SGTC_564 3555-0129 330 µM -1.13279729965942 0.170096897082346 no 2819 0.128649692857548 4078 563260 SGTC_1830 st055982 50.3 µM -1.13283134385783 0.170089291982662 no 2820 0.128642543039155 4190 455313 An antimicrobial agent. SGTC_2957 9076800 11.52 µM -1.1328851397848 0.170077275008199 no 2821 0.128631245608478 4193 16459615 SGTC_790 1575-0012 79.1 µM -1.13374854386381 0.169884481610092 no 2822 0.128450020355138 4279 378741 YLR208W SEC13 SGTC_2306 7482397 179.52 µM -1.13635174562509 0.169304049424859 no 2823 0.127904691211464 4242 891448 SGTC_2601 securinine 100 µM -1.1366566813824 0.169236141722257 no 2824 0.127840917460619 4204 442872 A GABA receptor antagonist. SGTC_2556 citropten 84.59 µM -1.13821095060942 0.168890285323367 no 2825 0.127516203583277 4263 2775 A potential DNA crosslinker. SGTC_3111 9122088 49.47 µM -1.13834088430209 0.168861393024975 no 2826 0.127489084173518 4074 16876704 SGTC_645 0845-0943 5.41 µM -1.13881055741453 0.168756982122626 no 2827 0.127391088720409 4241 1885106 SGTC_1930 st074634 34.3 µM -1.13910416528408 0.168691732565489 no 2828 0.127329855207733 4133 684253 YOR116C RPO31 SGTC_1066 ketoconazole 628 nM -1.13970974108965 0.168557204443697 no 2829 0.127203623758697 4297 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W SGTC_3257 9139206 32.98 µM -1.14262303416699 0.167910983338662 no 2830 0.126597568860168 4228 4910041 SGTC_2101 5377231 179.231 µM -1.14415674949521 0.167571419195295 no 2831 0.126279318087777 4275 2844213 SGTC_2918 7977171 22.06 µM -1.14570221938283 0.167229700357725 no 2832 0.125959192617667 4222 2236483 SGTC_2205 7238770 200 µM -1.14767910618882 0.166793246186254 no 2833 0.125550529825849 4299 279867 SGTC_2910 7948405 25.97 µM -1.14844368865289 0.166624640052379 no 2834 0.125392723440148 4146 2971328 SGTC_3340 9146634 11.102 µM -1.14984818441263 0.166315206621951 no 2835 0.125103202701973 4251 4907387 SGTC_1720 st037298 9.481 µM -1.15040919436175 0.166191710723145 no 2836 0.124987687503486 4235 597396 SGTC_2746 daunorubicin 9.88 µM -1.15051163729879 0.166169166214602 no 2837 0.124966601956802 4191 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_1479 0549-0158 134 µM -1.15086272784015 0.166091917079501 no 2838 0.124894356812693 4301 5440202 SGTC_620 0109-0052 432 µM -1.15174280840089 0.165898378247152 no 2839 0.124713387785717 4260 493037 SGTC_1632 st005650 90 µM -1.15206416793022 0.165827744301698 no 2840 0.124647353032284 4267 2759605 SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM -1.15336630647693 0.165541736818377 no 2841 0.124380032479965 4144 17037758 SGTC_1523 st012844 44.7 µM -1.15810227281262 0.164504200421306 no 2842 0.123411151308039 4332 4274103 SGTC_2183 6420625 130.508 µM -1.15838343978442 0.164442736316967 no 2843 0.123353797060207 4249 2897619 SGTC_3154 9100113 49.47 µM -1.16055727675224 0.16396803033342 no 2844 0.122910994115144 4263 25237525 SGTC_1491 4138-0063 26.5 µM -1.16061775054227 0.163954837250962 no 2845 0.122898691770976 4226 23883227 SGTC_2913 7966556 36.57 µM -1.16113128383547 0.16384283156447 no 2846 0.122794257121555 4135 2976516 SGTC_1785 bathophenanthroline 24 µM -1.16127163379241 0.163812228767607 no 2847 0.122765725698332 4171 72812 An iron chelator. SGTC_1719 st032227 49.2 µM -1.16634057704854 0.162709451029763 no 2848 0.121738386778696 4255 3125804 SGTC_3142 9086498 49.47 µM -1.16651790994178 0.162670958863912 no 2849 0.121702555844782 4131 25236367 SGTC_2842 9000675 19.48 µM -1.1668697181257 0.162594612342287 no 2850 0.12163149330468 4307 2989072 SGTC_2696 st077691 74.316 µM -1.16839052224345 0.162264848176999 no 2851 0.121324638111817 4316 757133 SGTC_1366 1683-0113 21.9 µM -1.16937518366629 0.162051571109022 no 2852 0.121126251885515 4257 708623 SGTC_389 tpck 16.7 µM -1.16971028338203 0.161979030372519 no 2853 0.121058789208478 4290 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.  SGTC_2080 5212524 12.4 µM -1.17228045272609 0.161423356166006 no 2854 0.120542238448102 4207 260183 SGTC_2764 methyldopa 94.69 µM -1.17403205706615 0.16104536998325 no 2855 0.120191092786258 4271 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent. SGTC_2159 5658611 73.75 µM -1.1792507549033 0.159922631820804 no 2856 0.119149170542688 4263 793844 SGTC_483 fpl-64176 144 µM -1.18176400646564 0.159383767670451 no 2857 0.118649676650888 4377 3423 SGTC_557 1315-0110 16.2 µM -1.18195487322215 0.159342892716888 no 2858 0.118611803547979 4272 6833801 SGTC_3137 9097352 49.47 µM -1.18234045601547 0.159260339410737 no 2859 0.118535319602379 4298 44120435 SGTC_3061 glucosamine 200 µM -1.18348558354584 0.159015332664355 no 2860 0.118308378352597 4198 91431 and experimental redox chemotherapeutic SGTC_2076 5212012 200 µM -1.18371490719644 0.158966297221697 no 2861 0.118262967958469 4225 604802 SGTC_2362 9071156 126 µM -1.18498088659211 0.158695775802862 no 2862 0.118012502041646 4276 653133 SGTC_56 0957-0365 83.25 µM -1.1854608615416 0.158593291078604 no 2863 0.117917640238905 4242 6752360 SGTC_394 menadione 8.33 µM -1.18756303131048 0.158144945134374 no 2864 0.117502804946385 4268 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_3043 9092303 49.47 µM -1.19236612293365 0.157123677583899 no 2865 0.116558858818118 4286 25236084 SGTC_2707 st078556 66.6 µM -1.19736720416091 0.156064931441421 no 2866 0.115581730332087 4222 17250899 SGTC_887 0885-0007 9.62 µM -1.19977624199757 0.155556611535272 no 2867 0.115113126739093 4336 5719458 SGTC_2189 6047310 154.431 µM -1.20110744990592 0.155276188559672 no 2868 0.114854761769165 4264 711535 SGTC_220 paclitaxel 373.376 µM -1.20208313795844 0.155070868940179 no 2869 0.114665659348568 4245 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_2097 5376186 200 µM -1.20541303352625 0.154371490429594 no 2870 0.114021946223595 4277 742755 SGTC_1586 deoxycorticosterone acetate 53.7 µM -1.20649085007892 0.154145563905489 no 2871 0.113814142497633 4286 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE. SGTC_2493 resveratrol 26.09 µM -1.20837680157437 0.153750766604806 no 2872 0.113451179440744 4210 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase. SGTC_2456 5770359 74.46 µM -1.20847542387749 0.15373013985205 no 2873 0.113432221705016 4297 3118787 SGTC_1886 st057356 49.9 µM -1.21271090458924 0.152846022155888 no 2874 0.112620184612109 4275 24207747 SGTC_1763 st044482 94.5 µM -1.21305841424106 0.152773632680225 no 2875 0.11255374394601 4284 88505 SGTC_2364 9055074 200 µM -1.21559048186357 0.152246866092067 no 2876 0.112070480882147 4302 6470630 SGTC_2571 chrysanthemic acid 100 µM -1.21635273107336 0.152088525622915 no 2877 0.111925291125455 4282 2743 An insecticide. SGTC_2176 5809774 33.9695 µM -1.21887396206206 0.15156557482216 no 2878 0.111446016860111 4237 2870539 SGTC_2827 7993847 71.43 µM -1.22071366303837 0.151184741411713 no 2879 0.111097226383786 4363 2985692 SGTC_2946 9065502 71.43 µM -1.2221927998982 0.15087900983647 no 2880 0.110817363017331 4132 16489101 SGTC_2938 9059746 27.26 µM -1.22241767933547 0.150832564237395 no 2881 0.110774858479501 4298 6471769 SGTC_1489 4065-0444 182 µM -1.22574005367601 0.150147484930452 no 2882 0.110148256129188 4312 2877968 SGTC_3242 9133940 49.47 µM -1.22582438333843 0.150130123043525 no 2883 0.110132384644016 4308 17248444 SGTC_2318 6029776 164 µM -1.2281232198719 0.149657351445915 no 2884 0.109700357835918 4348 818325 SGTC_1727 st034309 9.9045 µM -1.2295463360598 0.149365176125499 no 2885 0.109433518083827 4373 870305 SGTC_3290 9121031 71.43 µM -1.23273385378592 0.148712139806784 no 2886 0.108837538465501 4319 17014854 SGTC_2327 6189656 200 µM -1.23293675748058 0.148670635024473 no 2887 0.108799680118719 4396 5349088 SGTC_803 4488-1585 147 µM -1.23536588862408 0.148174347584374 no 2888 0.108347181020797 4311 747204 SGTC_1934 st074720 32.6 µM -1.23675654899908 0.147890726066828 no 2889 0.10808873887947 4259 17250992 SGTC_1924 st058459 75.1 µM -1.23789247738312 0.147659326321019 no 2890 0.107877966016478 4257 688683 SGTC_1387 3342-1166 1.8 µM -1.23898944910331 0.147436092714633 no 2891 0.107674702720216 4287 3418228 SGTC_496 calpeptin 138 µM -1.24076785131531 0.147074668793935 no 2892 0.107345760336336 4316 73364 A calpain inhibitor. SGTC_2413 inermin 26.06 µM -1.24427012328864 0.146364641822396 no 2893 0.106700081514736 4381 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1 SGTC_2627 acetyl isogambogic acid 100 µM -1.24429144878879 0.146360325495967 no 2894 0.106696158550008 4330 6857789 A caspase activator and apoptosis inducer. SGTC_2814 7977482 42.97 µM -1.24535176229406 0.14614582355764 no 2895 0.106501238206398 4333 6456762 SGTC_2435 5706476 10.6 µM -1.24568522397172 0.146078407766678 no 2896 0.106439990202457 4318 5725375 SGTC_660 4031-1742 102 µM -1.24575960348279 0.146063373345895 no 2897 0.106426332142561 4209 6738706 SGTC_1230 0170-0365 3.77 µM -1.24582958481489 0.146049228883519 no 2898 0.106413482860955 4364 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1 SGTC_27 0485-0001 32.618 µM -1.24652752102577 0.145908214009878 no 2899 0.106285395992274 4304 2054479 SGTC_766 1391-0721 126 µM -1.24731216775191 0.145749788953243 no 2900 0.106141528811536 4346 1020919 YIL115C NUP159 SGTC_398 bronopol 33.3 µM -1.24962607771712 0.145283269618465 no 2901 0.105718086191729 4247 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them. SGTC_189 3970-0742 2.116 µM -1.25035766924338 0.14513597893882 no 2902 0.105584460309524 4308 2891807 SGTC_147 4466-0538 29.23 µM -1.25241848278882 0.144721617555475 no 2903 0.105208707458055 4417 6742687 YHR072W ERG7 SGTC_1027 k015-0025 8.67 µM -1.25493503797732 0.144216703152233 no 2904 0.104751171643639 4318 3598955 SGTC_2563 tomatine 8.54 µM -1.25742826240319 0.143717642212762 no 2905 0.104299300278358 4305 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties. SGTC_2003 4023581 200 µM -1.25771856882328 0.143659608321656 no 2906 0.104246777181806 4346 16641307 SGTC_9 0092-0002 10.449 µM -1.25952439974458 0.143298967718957 no 2907 0.103920491397974 4336 759368 SGTC_2492 derrusnin 100 µM -1.25983124469806 0.143237748858144 no 2908 0.1038651229476 4359 1715307 Part of coumarin class of compounds. SGTC_1005 4092-0690 4.4 µM -1.26121981408487 0.142960935220218 no 2909 0.103614830884853 4352 1529343 SGTC_1794 st048918 76.9 µM -1.26265669040279 0.142674872332902 no 2910 0.103356292479162 4272 672303 SGTC_2894 9048625 32.47 µM -1.26303622364396 0.142599376990656 no 2911 0.103288080986254 4357 4092861 SGTC_2081 5214970 32.255 µM -1.26449784944936 0.142308888181342 no 2912 0.103025696057542 4290 2063512 SGTC_2703 st077852 53.4 µM -1.26540788195955 0.142128227400861 no 2913 0.102862575599277 4367 6281836 SGTC_3262 9137218 49.47 µM -1.26562539100307 0.142085070230583 no 2914 0.10282361558994 4281 17650664 SGTC_2858 9025781 8.96 µM -1.26730356874334 0.141752391959058 no 2915 0.102523382480746 4205 4894980 YPL153C RAD53 SGTC_2196 6573537 42.6665 µM -1.26824311187482 0.141566369533426 no 2916 0.102355572781512 4350 2903087 SGTC_2678 equilin 100 µM -1.27220265211805 0.140784228369089 no 2917 0.10165056278661 4332 3247 Equilin is an estrone commonly used hormone replacement therapy SGTC_3015 9080845 49.47 µM -1.27301712604258 0.140623706913271 no 2918 0.101505982360834 4379 5296973 SGTC_1036 k216-0215 33.5 µM -1.27326260013308 0.140575351763696 no 2919 0.1014624366889 4293 622330 SGTC_1618 st003135 44.5 µM -1.27528049542538 0.140178280823147 no 2920 0.101104989403946 4319 1270615 SGTC_2633 5,7-dihydroxyisoflavone 100 µM -1.27618855123897 0.139999847123045 no 2921 0.100944437376793 4358 5377381 SGTC_2504 purpurogallin 52.29 µM -1.27811817127491 0.139621187866063 no 2922 0.100603881368454 4249 5281571 An antioxidant. SGTC_1227 3909-8010 46.6 µM -1.27817563635465 0.139609921887154 no 2923 0.1005937523019 4340 15982272 SGTC_3105 9121040 49.47 µM -1.279408308999 0.13936840633307 no 2924 0.100376654701253 4267 41448907 SGTC_1179 1021-1431 9.29 µM -1.27959339801435 0.139332166700953 no 2925 0.100344086476114 4362 2840958 SGTC_2681 menadione 3.18 µM -1.27976986908026 0.139297620397189 no 2926 0.100313041845809 4381 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_2042 p-Dimethylaminoacetophenone 200 µM -1.27990672830612 0.13927083259372 no 2927 0.10028897052122 4335 75037 A free radical scavenger. SGTC_3042 9091578 49.47 µM -1.28024298218738 0.139205031655245 no 2928 0.100229846805454 4360 25236497 SGTC_2743 auranofin 4.32 µM -1.28326443729264 0.138614717540589 no 2929 0.0996997237061644 4371 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold. SGTC_587 k089-0003 57 µM -1.28508773353081 0.138259318908971 no 2930 0.0993808137769414 4269 9659696 SGTC_3101 9120531 49.47 µM -1.28891665506046 0.137515005355176 no 2931 0.0987135316060578 4353 24824904 SGTC_2879 9041815 71.43 µM -1.28902145145045 0.137494672257097 no 2932 0.0986953145157458 4383 4942971 SGTC_3170 9103054 49.47 µM -1.29314888804116 0.136695479302759 no 2933 0.097979784681316 4332 16432970 SGTC_549 1661-1316 519 µM -1.29466490000215 0.136402733971451 no 2934 0.0977179266577318 4386 2857282 SGTC_2514 salinomycin 42.74 µM -1.29522749081634 0.136294205604856 no 2935 0.0976208820040595 4414 23682228 A polyether potassium ionophore. SGTC_878 0828-0289 13.7 µM -1.30054536604246 0.135271262708309 no 2936 0.0967070591015155 4306 745350 YLR208W SEC13 SGTC_1132 3456-3614 2.5 µM -1.30129113708793 0.13512822860097 no 2937 0.096579409888594 4380 3125502 SGTC_430 0958-0115 16.4 µM -1.30436933380328 0.134538947845389 no 2938 0.0960538429024757 4304 6833180 SGTC_1572 epiandrosterone 68.9 µM -1.30456316154876 0.134501901169278 no 2939 0.0960208195412487 4303 441302 A steroid. SGTC_2416 tofa 880 nM -1.30718492069182 0.134001487174356 no 2940 0.0955749577748102 4330 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_403 arphamenine a 50 µM -1.31603041309214 0.132322598572481 no 2941 0.0940819175281047 4367 5487158 An arginine aminopeptidase inhibitor. SGTC_227 fluconazole 33.516 µM -1.31965988993816 0.131637930826673 no 2942 0.0934742987067504 4379 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C SGTC_69 0096-0274 206.684 µM -1.31989910337473 0.131592891426477 no 2943 0.0934343534992685 4485 6741392 SGTC_1113 artemisinin 1.17947 µM -1.32011338572856 0.131552555112964 no 2944 0.0933985821318307 4419 2240 An anti-malaria and mitochondrial poison. SGTC_3024 9090631 49.47 µM -1.32090679422437 0.13140327892824 no 2945 0.0932662220298442 4334 25236383 SGTC_3157 9099274 49.47 µM -1.32134220814158 0.131321407507792 no 2946 0.0931936431759049 4406 17217662 SGTC_1269 0831-0796 3.05 µM -1.32175166678922 0.131244448632095 no 2947 0.0931254288749926 4406 927758 SGTC_1111 tnp00062 510.699 nM -1.32214294464728 0.131170935994558 no 2948 0.0930602779126882 4405 676306 SGTC_1081 sertraline 6 µM -1.33034614766683 0.129636277941735 no 2949 0.0917021245076073 4365 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1 SGTC_1973 st070275 50.2 µM -1.33220530893432 0.129290201159004 no 2950 0.0913963662508333 4332 17118334 SGTC_2702 st077768 96.8 µM -1.33474015409729 0.128819380541345 no 2951 0.0909807032878528 4363 6484119 SGTC_1434 4073-0095 163 µM -1.33674742367562 0.128447396276944 no 2952 0.0906525481353389 4389 24133745 SGTC_669 0108-0021 26.2 µM -1.33908221960303 0.128015654179394 no 2953 0.0902719540629765 4412 17201 SGTC_718 1130-0073 349 µM -1.33944538566 0.127948589522193 no 2954 0.0902128613337729 4407 6740020 SGTC_1809 st050081 57.6 µM -1.33960975085653 0.127918244778375 no 2955 0.0901861260234722 4460 5036894 SGTC_129 0088-0017 176.636 µM -1.34444706691332 0.127027428557568 no 2956 0.089401931242314 4249 182446 SGTC_2816 7982706 58.44 µM -1.34599770866583 0.126742786032403 no 2957 0.0891516277703111 4377 2981853 SGTC_3294 9122953 26.2835 µM -1.34653891905707 0.126643543742632 no 2958 0.0890643888655665 4368 16459826 SGTC_1948 st076329 66.6 µM -1.34688487668209 0.126580133509315 no 2959 0.0890086564859643 4315 24208413 SGTC_167 3672-0051 66.205 µM -1.34948013732058 0.126105155905429 no 2960 0.0885913980044832 4308 3237971 SGTC_370 0180-0345 38.7 µM -1.35141480825091 0.125751886960335 no 2961 0.0882812964198887 4242 3989527 SGTC_722 3534-0461 190 µM -1.35147272007294 0.12574132297275 no 2962 0.0882720264244549 4427 658262 SGTC_88 0180-0332 8.668 µM -1.35241762520784 0.125569045511599 no 2963 0.0881208771140678 4497 3101745 SGTC_1590 st077108 57.8 µM -1.35475001827788 0.12514450305784 no 2964 0.0877486079461255 4417 5489485 SGTC_2995 9067767 71.4286 µM -1.3555123369837 0.125005963315355 no 2965 0.0876271903331701 4417 11673567 SGTC_1717 st033143 58.0435 µM -1.35862404497262 0.124441569376933 no 2966 0.0871328759015972 4453 674616 SGTC_894 0960-0238 55.9 µM -1.35906347858505 0.124362009795256 no 2967 0.0870632372367603 4399 6741907 YDL195W SEC31 SGTC_2761 levamisole 97.89 µM -1.35943671914178 0.124294462428579 no 2968 0.0870041210844348 4415 26879 An alkaline phosphatase inhibitor. SGTC_580 1123-0028 41 µM -1.36162812314141 0.123898389788551 no 2969 0.0866576376131 4473 1677248 YPR107C YTH1 SGTC_758 0868-0029 16 µM -1.36362558290384 0.123538140790714 no 2970 0.0863427180747444 4393 762687 SGTC_2939 9044578 71.43 µM -1.36487305974653 0.123313526391805 no 2971 0.0861464754683077 4338 2653634 SGTC_1703 st026983 48.3 µM -1.36546402825246 0.123207219523378 no 2972 0.0860536258080133 4432 1104023 SGTC_1042 0350-0096 82 µM -1.36675971695811 0.122974368280123 no 2973 0.0858503165303444 4409 3122515 SGTC_2078 5212016 200 µM -1.36714414120573 0.122905341887717 no 2974 0.0857900649116585 4315 1899708 SGTC_2738 aclarubicin 5.55 µM -1.36866318036705 0.122632852264359 no 2975 0.0855522923434081 4444 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31 SGTC_3071 9117417 49.47 µM -1.37072595076417 0.122263505487535 no 2976 0.0852302009834465 4361 45595590 YGL055W OLE1 SGTC_2739 tacrine 100.86 µM -1.37310403839469 0.121838669886326 no 2977 0.084860002899065 4466 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders. SGTC_2931 9014674 55.67 µM -1.37826729426902 0.120919848388755 no 2978 0.0840603885283818 4375 2996810 SGTC_2868 9035608 32.47 µM -1.37895993294709 0.120796962542159 no 2979 0.0839535538890629 4392 6462614 SGTC_3297 9117502 71.43 µM -1.38340470764099 0.120010475890181 no 2980 0.0832704039455238 4441 7453720 SGTC_1684 st024538 14.6195 µM -1.38716104636114 0.119348625069891 no 2981 0.0826963302946084 4390 6732859 SGTC_2155 5570423 76 µM -1.38997810735326 0.118853964048028 no 2982 0.0822677627063232 4393 797402 SGTC_23 0213-0011 39.996 µM -1.39097954644533 0.118678466008334 no 2983 0.0821158145845716 4425 627608 SGTC_154 3389-1638 511.116 µM -1.39216801175031 0.118470430069052 no 2984 0.0819357634620319 4420 5238686 SGTC_3197 9113331 49.47 µM -1.39308944785593 0.118309313968098 no 2985 0.0817963718188802 4419 16610459 YLR208W | YDL195W SEC13 | SEC31 SGTC_2046 4110841 106 µM -1.39431568665442 0.118095142463138 no 2986 0.081611147990124 4429 44119630 YMR134W ERG29 SGTC_255 tunicamycin 200.472 nM -1.39448478739386 0.118065629319889 no 2987 0.0815856300921813 4353 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_589 1227-0070 34.1 µM -1.39553680991917 0.117882137064403 no 2988 0.0814270113061678 4477 2841384 SGTC_2040 5100729 123 µM -1.39582354895916 0.117832159463948 no 2989 0.0813838185663129 4456 11840 YJR013W | YDR381W GPI14 | YRA1 SGTC_4 0960-0234 25.671 µM -1.40199473462541 0.116760175568353 no 2990 0.0804584095157778 4433 6821112 SGTC_2462 5162487 171.77 µM -1.40398498106083 0.116415932999134 no 2991 0.0801616609789075 4392 2259986 SGTC_2277 7947813 106.88 µM -1.40400554260411 0.116412380337486 no 2992 0.0801585995474009 4463 1246798 SGTC_1688 st021091 57.6 µM -1.40423567629904 0.116372622657699 no 2993 0.0801243407103216 4453 3656366 SGTC_2905 7799065 20.05 µM -1.40665152855661 0.115955843562034 no 2994 0.0797653727097286 4315 1296806 SGTC_1643 st009866 20.2 µM -1.40789304523303 0.11574207174471 no 2995 0.0795813713914099 4399 3156273 YOR207C RET1 SGTC_1084 voriconazole 435 nM -1.40820326934225 0.115688699226294 no 2996 0.0795354442327793 4454 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_340 k038-0059 454 µM -1.4106331565881 0.115271253860304 no 2997 0.0791764048821248 4412 23733424 SGTC_1373 2887-0003 58.5 µM -1.41133378485118 0.115151087714211 no 2998 0.0790731085611078 4397 776948 SGTC_658 3253-0951 102 µM -1.41251791683093 0.114948197402526 no 2999 0.0788987594805923 4462 1184878 SGTC_346 4513-0042 7.16 µM -1.41307262373801 0.114853240889427 no 3000 0.0788171858446679 4384 2827372 SGTC_1085 doxorubicin 7.67 µM -1.41464919823091 0.114583662509104 no 3001 0.0785856881390836 4446 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_3038 9091290 49.47 µM -1.4148543840586 0.114548610941833 no 3002 0.0785555974377454 4445 25236843 SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM -1.41786495236541 0.114035197630203 no 3003 0.0781150982338785 4451 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding. SGTC_2288 7946289 167.31 µM -1.41871731789643 0.113890135990573 no 3004 0.0779907231229617 4472 1246052 SGTC_2724 maprotiline 69.64 µM -1.42278048915532 0.11320044397571 no 3005 0.0773998995263619 4392 4011 A tricyclic antidepressant. SGTC_518 1021-0119 62.6 µM -1.42461929161279 0.112889302784862 no 3006 0.0771336402058804 4420 1097762 SGTC_896 0964-0007 44.5 µM -1.42606734310732 0.112644710048651 no 3007 0.0769244520936685 4402 6756758 SGTC_3354 9151612 71.43 µM -1.42628063176813 0.112608715116466 no 3008 0.0768936765046673 4443 27261949 SGTC_248 streptozotocin 5.23457 mM -1.42756652770473 0.112391879333099 no 3009 0.0767083318540337 4483 5300 DNA alkylating agent. SGTC_2249 haloperidol 116.36 µM -1.42890163164212 0.112167061623129 no 3010 0.0765162542122881 4408 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_1160 4092-0570 10.5 µM -1.43509986148672 0.111127553806434 no 3011 0.0756293215166034 4472 4994975 SGTC_1650 st011916 45.8 µM -1.43603216050965 0.110971796331639 no 3012 0.0754965950693536 4407 242528 SGTC_3341 9147222 25.867 µM -1.43680636890404 0.110842569661684 no 3013 0.0753865101103698 4461 1939759 SGTC_3096 9117468 49.47 µM -1.43755650074483 0.110717464590615 no 3014 0.0752799653446449 4415 41316311 SGTC_3054 9094397 49.47 µM -1.43759248511965 0.110711465753007 no 3015 0.0752748572009602 4458 2598354 SGTC_2372 9071633 200 µM -1.44010510750731 0.110293170454711 no 3016 0.0749188321551789 4497 21321366 SGTC_2324 6149169 200 µM -1.44053760299824 0.11022128413712 no 3017 0.0748576796656772 4391 2888231 SGTC_622 1348-1566 26.3 µM -1.44121538011026 0.11010869646436 no 3018 0.0747619223100777 4454 7340407 SGTC_2629 bisabolol 100 µM -1.44129846868924 0.110094900039933 no 3019 0.0747501898664792 4484 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer. SGTC_633 0437-0093 97.7 µM -1.44239908024802 0.109912266243119 no 3020 0.0745949115893017 4384 2831118 SGTC_2847 9005661 71.43 µM -1.44368827807454 0.109698615341732 no 3021 0.0744133400965152 4503 2991449 SGTC_1162 k048-0130 20.1 µM -1.44479176100331 0.109515978787505 no 3022 0.0742581930025296 4443 6797406 SGTC_298 1391-0729 10 µM -1.44642659503411 0.109245800305824 no 3023 0.0740287934604936 4403 3237558 SGTC_344 k064-0035 6.43 µM -1.44741305060528 0.109083006990552 no 3024 0.0738906363786672 4416 5088750 SGTC_1844 rapamycin 4 nM -1.44880350239961 0.108853838944671 no 3025 0.0736962327087277 4308 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2 SGTC_913 3487-1245 167 µM -1.44932439607062 0.108768076768338 no 3026 0.0736235055964049 4403 4016153 SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM -1.44987322764563 0.108677767352842 no 3027 0.0735469371754743 4446 689007 SGTC_1827 berberine 7.24 µM -1.45066912133781 0.108546900059881 no 3028 0.0734360088939039 4369 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_2186 6124449 200 µM -1.4512416791101 0.108452825604233 no 3029 0.073356287391768 4478 3834182 YLR033W RSC58 SGTC_3059 1327-0034 3 µM -1.45189786429976 0.108345082848926 no 3030 0.0732650032447829 4313 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_422 cantharidin 155 µM -1.45271320727006 0.10821131442084 no 3031 0.0731516992234646 4386 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_1379 2144-0755 36.5 µM -1.45297027201767 0.108169164009234 no 3032 0.0731160040708296 4513 5392327 SGTC_3230 9131665 49.47 µM -1.45351457126163 0.108079955318039 no 3033 0.0730404684843804 4479 15943720 SGTC_812 4251-0442 148 µM -1.45679485104056 0.107543450623356 no 3034 0.0725865088208197 4498 5723007 SGTC_1091 telmisartan 47.6 µM -1.45835228816062 0.107289397687035 no 3035 0.072371732288606 4495 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension. SGTC_3231 9132313 49.47 µM -1.46282754945502 0.106561790820763 no 3036 0.0717572863334113 4426 4905967 SGTC_1570 verbenone 133 µM -1.46336977946314 0.106473875297516 no 3037 0.0716831116490796 4498 29025 A natural terpanoid with antifungal properties. SGTC_10 0279-0212 42.575 µM -1.46397289403536 0.106376149667652 no 3038 0.0716006773356407 4481 39851 YBR002C RER2 SGTC_876 0720-0963 56.8 µM -1.46398943311952 0.106373470671 no 3039 0.0715984177818417 4492 765861 SGTC_2342 7990637 118.86 µM -1.46763430156046 0.10578426371258 no 3040 0.0711017926705886 4453 2033102 YER133W GLC7 SGTC_1780 st038448 24.544 µM -1.4713125407335 0.105192057592363 no 3041 0.0706033066810907 4497 728868 YDL195W SEC31 SGTC_1561 5-methoxyflavone 52.9 µM -1.47436148970805 0.104702990294062 no 3042 0.0701921436954216 4445 94525 SGTC_3253 9135987 49.47 µM -1.47598914874133 0.10444258052249 no 3043 0.069973402653976 4487 4182430 SGTC_2643 anethole 100 µM -1.47928872588807 0.103916120546961 no 3044 0.0695315823748883 4479 637563 An anti-fungal, anti-helmenthic and channel blocker. SGTC_1145 3546-0597 10.2 µM -1.4818506688515 0.103508682166019 no 3045 0.0691900167940681 4451 875334 SGTC_1813 st051246 8.6015 µM -1.49274007834635 0.101789821881454 no 3046 0.0677526189847344 4446 5291959 SGTC_1701 st028638 40.4 µM -1.49295170922249 0.101756623670902 no 3047 0.0677249140472837 4506 3490878 SGTC_2999 9069765 71.4286 µM -1.49581039888235 0.101308957542883 no 3048 0.0673515353580435 4441 2097066 SGTC_1999 st074831 12.5 µM -1.49773943733127 0.101007685166336 no 3049 0.0671004806122378 4471 17112523 SGTC_1252 0493-0875 34.8 µM -1.49825858503203 0.100926717626082 no 3050 0.0670330398651192 4491 3960963 SGTC_29 0299-0004 12.984 µM -1.49880471750328 0.100841592557425 no 3051 0.0669621502114066 4407 16871 A napthoquinone isolated from Swertia calycina. SGTC_2524 avocatin b 10.57 µM -1.49981134468546 0.100684827882369 no 3052 0.0668316389090174 4503 6710748 SGTC_2922 7999257 32.47 µM -1.50044839867669 0.100585709686094 no 3053 0.0667491452786601 4458 2988377 SGTC_2586 curcumin 80 µM -1.50090683958708 0.100514425664503 no 3054 0.0666898294481353 4384 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40 SGTC_259 usnic acid 108.925 µM -1.50304285439995 0.100182777759424 no 3055 0.0664139967212505 4542 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_2199 6590217 200 µM -1.50318546702813 0.100160663519897 no 3056 0.0663956120462248 4453 703109 SGTC_1712 st032288 53.4 µM -1.50340823119667 0.100126127705875 no 3057 0.0663669026508896 4304 2883011 SGTC_3336 9143619 71.43 µM -1.50384080443822 0.10005908937977 no 3058 0.066311180943654 4502 45595730 SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM -1.50452878565367 0.0999525365539646 no 3059 0.0662226336255196 4503 2374 Ca(2+)-ATPase inhibitor. SGTC_2711 st079103 59.1 µM -1.50706688678117 0.0995601585107194 no 3060 0.0658967567139991 4438 54693780 SGTC_1248 0469-0687 58.6 µM -1.50851340948874 0.0993370373672172 no 3061 0.0657115886558778 4459 4017482 SGTC_1097 itavastatin 7.23 µM -1.50901585784294 0.0992596220453171 no 3062 0.0656473651693694 4521 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49 SGTC_169 k015-0017 16.025 µM -1.51317626326662 0.098620296999655 no 3063 0.0651174459670826 4476 1840002 SGTC_2944 9067346 25.62 µM -1.5149978037193 0.0983413335774203 no 3064 0.064886480155531 4429 6473075 SGTC_1455 4262-0120 131 µM -1.51528172112664 0.0982979045922989 no 3065 0.064850537649829 4542 1529587 SGTC_1790 st045711 43.5 µM -1.51713026951013 0.0980154876800593 no 3066 0.06461689862529 4484 585119 SGTC_1525 8-methoxypsoralen 92.5 µM -1.52061583616034 0.0974845892929344 no 3067 0.0641781352058308 4531 4114 Related to psoralen; DNA damaging agent. SGTC_1818 st052136 56.3 µM -1.52310424720971 0.0971068634494885 no 3068 0.0638663132202036 4149 674169 SGTC_1784 st039334 36.3 µM -1.52791894859956 0.0963790726020276 no 3069 0.0632663314710367 4499 3496984 SGTC_1295 1013-0063 9.78 µM -1.52919595119849 0.0961867150137688 no 3070 0.0631079370100892 4519 6826038 SGTC_2620 irigenin 100 µM -1.52961051320878 0.0961243293876071 no 3071 0.0630565828001061 4496 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro. SGTC_256 clotrimazole 625 nM -1.5321880652117 0.0957371122022358 no 3072 0.0627380164055901 4454 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C SGTC_1189 1431-2119 7.28 µM -1.53273451464156 0.0956551685315637 no 3073 0.0626706407035007 4497 3107275 SGTC_2483 5729050 27.16 µM -1.53317293253056 0.0955894622185825 no 3074 0.0626166257752049 4485 2865180 SGTC_1310 1188-0297 994 nM -1.53334143571806 0.0955642172438487 no 3075 0.0625958751300382 4395 1588352 SGTC_2006 4011487 200 µM -1.53920761151819 0.0946884088682818 no 3076 0.0618768100060013 4475 45595294 SGTC_1034 k072-0165 12.7 µM -1.54283063028485 0.0941504626909151 no 3077 0.061435937767908 4532 5835461 SGTC_940 3232-1287 54.8 µM -1.54377413473875 0.0940107418010728 no 3078 0.0613215297135686 4498 1585493 YIL048W NEO1 SGTC_33 0986-0033 35.816 µM -1.54501590477206 0.0938270848906718 no 3079 0.0611712081653934 4498 2848082 SGTC_1697 st025554 27.742 µM -1.54501620042957 0.0938270411946921 no 3080 0.0611711724091138 4532 1269519 SGTC_912 3474-0017 2.18 µM -1.54783794162827 0.0934106927096883 no 3081 0.0608306595108799 4527 3360550 SGTC_1569 carminic acid 40.6 µM -1.54821203984595 0.0933555970607281 no 3082 0.0607856267985636 4588 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_1367 1812-0510 76.9 µM -1.54834819117354 0.0933355512120801 no 3083 0.0607692438220247 4578 1142582 YDR527W RBA50 SGTC_1893 st059353 36.1 µM -1.54927353494101 0.0931993951303504 no 3084 0.060657989443152 4513 3112488 SGTC_1636 st007707 68.9 µM -1.55143983772947 0.0928812171007417 no 3085 0.0603981572470262 4531 403051 SGTC_2125 5246583 200 µM -1.55166346156008 0.0928484178996112 no 3086 0.0603713848733849 4521 835267 SGTC_729 4092-0585 94.1 µM -1.55299824471243 0.0926528216000729 no 3087 0.0602117769773669 4534 2169061 SGTC_2461 5755302 26.15 µM -1.5532917892165 0.0926098471215925 no 3088 0.0601767204786154 4533 2788904 SGTC_1333 1482-0047 286 µM -1.56596807643923 0.0907680958639945 no 3089 0.0586780454641513 4566 3811116 SGTC_447 ml7 120 µM -1.56739849037752 0.0905619882426018 no 3090 0.0585107883081679 4583 4216 Selective myosin light chain kinase inhibitor. SGTC_1829 berberine 14.4 µM -1.57332027333683 0.0897124171946618 no 3091 0.0578223386668636 4496 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_2219 9098279 200 µM -1.57770476961581 0.0890872214531271 no 3092 0.057316725024023 4471 902349 SGTC_444 curcumin 90.4 µM -1.58096784400665 0.0886240407566469 no 3093 0.0569426951619395 4451 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. SGTC_1223 0764-0573 147 µM -1.5816890285148 0.0885219138850514 no 3094 0.0568602892898089 4533 1609797 SGTC_3314 9135860 59.4275 µM -1.58293303396751 0.0883459564821095 no 3095 0.0567183642370979 4520 25252478 SGTC_128 0906-2981 13.371 µM -1.58308103136204 0.0883250404642232 no 3096 0.0567014982245611 4528 6740226 SGTC_2780 5215298 71.43 µM -1.58515622167197 0.0880321487239377 no 3097 0.0564654221813107 4548 2834131 SGTC_112 phenothiazine 287.218 µM -1.58634061850388 0.0878653082443284 no 3098 0.0563310314515387 4501 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.  SGTC_2267 7931562 200 µM -1.58660389607489 0.0878282536146245 no 3099 0.0563011922433928 4496 934880 SGTC_567 1080-0542 68.4 µM -1.58721487171825 0.0877423076228044 no 3100 0.0562319938331592 4434 5950415 SGTC_1386 3228-0095 33.8 µM -1.58895298405463 0.087498150362795 no 3101 0.0560355038769539 4535 870181 SGTC_2648 atorvastatin 78.68 µM -1.5894497835566 0.0874284568793346 no 3102 0.0559794413572386 4526 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11 SGTC_2671 danthron 100 µM -1.59212996224229 0.0870531827901733 no 3103 0.0556777530285974 4535 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin. SGTC_783 0848-0141 92.7 µM -1.59651412641996 0.0864419151247128 no 3104 0.055187027194906 4478 6755076 YHR007C | YLR033W ERG11 | RSC58 SGTC_1249 0481-0015 10.2 µM -1.59816617695974 0.0862124102668099 no 3105 0.0550029994728088 4490 4227577 SGTC_810 3825-7150 143 µM -1.59984237402129 0.0859800170685769 no 3106 0.0548167779095439 4563 22330411 YGL099W LSG1 SGTC_2093 5331342 194.4 µM -1.60007434456578 0.085947892906622 no 3107 0.0547910458287139 4581 33839 SGTC_75 0159-0059 199.013 µM -1.60161912244301 0.0857341952258142 no 3108 0.0546199297925717 4580 5377270 SGTC_132 0417-1715 25.805 µM -1.60673672152343 0.0850290907677918 no 3109 0.0540560672745022 4511 6769098 SGTC_1102 cgs 12066b 26.1 µM -1.60751720530239 0.0849219385486336 no 3110 0.0539704791170926 4567 6438352 A 5-HT1B full agonist. SGTC_2662 daunorubicin 22.37 µM -1.61169356644183 0.0843502875525055 no 3111 0.0535143191835889 4437 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_1306 1185-0270 9.02 µM -1.6227381607242 0.0828524487589809 no 3112 0.0523226950372303 4564 1548076 SGTC_979 1426-2828 121 µM -1.62991625180705 0.0818897595783743 no 3113 0.0515595991702906 4618 747872 SGTC_1169 aniline yellow 25.8 µM -1.63089153481109 0.0817596127236493 no 3114 0.0514566041341466 4511 6051 A DNA damaging agent. SGTC_1597 7-benzyloxygramine 47.5 µM -1.63290435730761 0.0814915042166761 no 3115 0.051244556797135 4459 260807 SGTC_2815 7968870 71.43 µM -1.63373319292545 0.0813812960091451 no 3116 0.0511574427410334 4484 2977326 YHR190W ERG9 SGTC_1315 1237-0019 3.69 µM -1.63437446357578 0.0812961050153668 no 3117 0.0510901234298143 4572 825140 SGTC_2949 9072542 2.23 µM -1.63550775111587 0.0811457154988874 no 3118 0.0509713255738421 4533 16457352 SGTC_1958 st076513 41.9 µM -1.63554089431904 0.0811413204913785 no 3119 0.0509678546207419 4492 732122 YGL099W LSG1 SGTC_939 1165-0479 45.3 µM -1.6368199532127 0.0809718460342261 no 3120 0.0508340476507807 4529 1377347 SGTC_2768 sulfasalazine 50.2 µM -1.63915840700411 0.0806626934358396 no 3121 0.0505901368006451 4536 5384001 An antioxidant and salicylic acid derivative. SGTC_319 1348-1596 45.5 µM -1.65105917233719 0.079103164681048 no 3122 0.0493632464681361 4619 5380505 SGTC_486 niguldipine 82 µM -1.65289325559734 0.0788648627929367 no 3123 0.049176295000225 4642 1236 A calcium channel blocker. SGTC_1842 st055362 61.2 µM -1.65416303583126 0.0787001995067041 no 3124 0.0490471955500048 4535 676032 SGTC_515 4092-1064 102 µM -1.65519018671675 0.0785671907712702 no 3125 0.0489429625980322 4541 717353 SGTC_685 1278-0033 54.9 µM -1.65671086603468 0.0783705865709132 no 3126 0.0487889725471829 4613 3590572 SGTC_2740 felodipine 17.08 µM -1.65703371119803 0.0783288949063283 no 3127 0.0487563298414844 4633 3333 L-type calcium channel blocker SGTC_2585 alliin 100 µM -1.66438923347915 0.0773835660557719 no 3128 0.0480173351234479 4585 87310 A garlic compound which reacts with lipids. SGTC_3250 9135583 49.47 µM -1.66793255804457 0.0769312835369722 no 3129 0.0476645578025754 4589 7699353 SGTC_1115 galangin 695.678 nM -1.67426848929112 0.0761275558062709 no 3130 0.0470389222186648 4646 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_2257 7960413 200 µM -1.67717532328046 0.0757609629338052 no 3131 0.0467541014953133 4620 2974689 YIL048W NEO1 SGTC_2052 5265182 7.135 µM -1.67960991708672 0.0754549622339234 no 3132 0.0465166184509625 4555 1239884 SGTC_1711 st032263 62.8 µM -1.68275285866829 0.0750613242719319 no 3133 0.0462114721799247 4589 3958979 SGTC_1195 1502-0147 41.1 µM -1.68459060005094 0.0748318828994949 no 3134 0.0460337930885 4587 817940 SGTC_2670 beta-carotene 100 µM -1.68558762489188 0.0747076287887783 no 3135 0.0459376272130351 4580 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.) SGTC_406 estrone 100 µM -1.68629263272819 0.0746198623322573 no 3136 0.0458697246783143 4576 5870 A steroid. SGTC_875 0709-0210 25.7 µM -1.68630123251846 0.0746187922300073 no 3137 0.0458688968913026 4561 6251364 SGTC_987 1497-1013 404 µM -1.69013058232936 0.0741434554925766 no 3138 0.0455014876125142 4590 1676435 SGTC_76 0433-0009 400.328 µM -1.69327125176655 0.0737553338110088 no 3139 0.0452019237910069 4624 2841569 SGTC_339 3091-4833 71.4 µM -1.69499331300636 0.0735431829371486 no 3140 0.045038344660761 4403 3240077 SGTC_3032 9089427 49.47 µM -1.69928823703944 0.0730160992578754 no 3141 0.0446324439179707 4561 17173707 SGTC_2421 5690543 90.72 µM -1.7005312322865 0.0728640965438041 no 3142 0.0445155234078547 4575 3397993 SGTC_833 3852-0053 558 µM -1.70251738442822 0.072621718026356 no 3143 0.0443292112116036 4628 3123681 SGTC_1144 3486-0183 12.5 µM -1.70478138681257 0.072346185924732 no 3144 0.0441176021018098 4591 6744069 SGTC_2829 7992743 58.44 µM -1.7068446711001 0.0720957797820974 no 3145 0.0439254634863178 4554 16462845 SGTC_1 0258-0098 57.368 µM -1.70735097822316 0.0720344345273968 no 3146 0.0438784180698257 4514 6790032 YDR047W HEM12 SGTC_1308 1187-1617 41.4 µM -1.707727249237 0.0719888706529573 no 3147 0.0438434817758485 4610 2882570 SGTC_484 loperamide 105 µM -1.70934516014145 0.0717932043365476 no 3148 0.0436935163571346 4693 3955 An opioid-receptor agonist. SGTC_280 3448-3607 3.04 µM -1.70942668655001 0.0717833555311504 no 3149 0.0436859705780223 4551 626179 SGTC_2160 5660466 132.927 µM -1.71019434691603 0.071690669061395 no 3150 0.0436149703622523 4548 2859134 SGTC_2540 epiandrosterone 100 µM -1.71305497938019 0.0713460877751654 no 3151 0.0433512127221252 4621 441302 A steroid. SGTC_2133 5320837 200 µM -1.71473471072449 0.0711443467399611 no 3152 0.0431969382858583 4600 2841355 SGTC_3084 9116877 49.47 µM -1.71521578982799 0.0710866483873407 no 3153 0.0431528354915298 4553 27241325 SGTC_1625 st003711 30.1 µM -1.71854043321323 0.0706888881880403 no 3154 0.0428490430124595 4601 24207034 YER133W GLC7 SGTC_859 0439-0102 54.6 µM -1.71886333677295 0.0706503473257073 no 3155 0.0428196297083569 4631 610143 SGTC_1860 st056228 74.6 µM -1.71892506667888 0.0706429812565034 no 3156 0.0428140085860585 4584 688679 SGTC_482 fipronil 114 µM -1.72024094613726 0.0704861011349976 no 3157 0.042694326462137 4704 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels. SGTC_203 k066-0004 30.888 µM -1.72199032443262 0.0702779538349872 no 3158 0.0425356356159327 4641 6795412 SGTC_1114 scopoletin 1.73284 µM -1.72814977214962 0.0695488414756246 no 3159 0.041980688040489 4629 5280460 A coumarin with genotoxic properties. SGTC_1820 st053765 18.6 µM -1.72918638752181 0.0694267088760897 no 3160 0.0418878709186106 4624 3690829 SGTC_2747 doxorubicin 7.63 µM -1.73009153307415 0.0693202010146117 no 3161 0.0418069613713367 4662 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_1335 1486-0900 202 µM -1.7304066329952 0.0692831529705449 no 3162 0.0417788247964166 4602 X1335 SGTC_1547 harmine 94.2 µM -1.73136992379367 0.0691699881232566 no 3163 0.0416929036678768 4518 5280953 A monoamine oxidase inhibitor YHR072W ERG7 SGTC_2875 9039966 71.43 µM -1.73567459788515 0.0686660259709968 no 3164 0.0413106937389401 4595 6463691 SGTC_1467 k284-1082 293 µM -1.73590693794011 0.0686389059237592 no 3165 0.0412901454283266 4573 3334705 SGTC_2237 6667747 47.222 µM -1.73830940618175 0.068358960359811 no 3166 0.0410781549260343 4600 729940 YDL015C TSC13 SGTC_2896 9052656 71.43 µM -1.7383140854707 0.068358415970589 no 3167 0.0410777428948457 4279 6469436 SGTC_2190 6049624 200 µM -1.73897985642046 0.0682809941646311 no 3168 0.0410191530988602 4537 2265554 SGTC_898 1000-0849 28.3 µM -1.74104099832799 0.0680417351361497 no 3169 0.0408381961567138 4609 6751807 SGTC_1854 st056233 32.9 µM -1.74285785966008 0.0678313695962488 no 3170 0.0406792232819737 4542 5393174 SGTC_2275 7947463 200 µM -1.74367348246079 0.067737096117393 no 3171 0.0406080209252851 4569 1225414 SGTC_2276 7947513 42.08 µM -1.74823331417915 0.0672119130176405 no 3172 0.0402118175692603 4533 2105100 SGTC_2699 st077704 54.6 µM -1.75511356269317 0.0664254398062493 no 3173 0.0396199424411023 4599 645852 SGTC_2928 9011484 9.79 µM -1.75535503842186 0.0663979669772726 no 3174 0.0395992988128485 4587 2994751 SGTC_2490 carminic acid 95.39 µM -1.75702760514058 0.0662079195683531 no 3175 0.0394565520154564 4603 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_2129 girgensonine 121.053 µM -1.75932942845224 0.0659470613627136 no 3176 0.0392607854587722 4590 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_1276 0871-0068 94.2 µM -1.76210599782839 0.0656334622848957 no 3177 0.0390256950599536 4624 3414906 SGTC_1236 0330-0013 258 µM -1.76270902356319 0.0655655067331273 no 3178 0.0389747890364974 4636 4617066 SGTC_3183 9108214 49.47 µM -1.76281095810059 0.0655540250243985 no 3179 0.0389661893057684 4627 4974831 SGTC_1022 4477-0945 21.3 µM -1.76542439698297 0.0652601844380273 no 3180 0.038746233049753 4563 4648966 SGTC_655 k060-0012 42 µM -1.76769300727633 0.0650059438898953 no 3181 0.0385561198248969 4620 5994525 SGTC_2348 9022543 33.42 µM -1.76820998020065 0.0649481150271176 no 3182 0.0385129031786532 4621 3162678 YDL140C RPO21 SGTC_3255 9139072 49.47 µM -1.769092391145 0.0648495003399301 no 3183 0.0384392287408119 4620 17646060 SGTC_205 1486-1330 71.903 µM -1.77218544077738 0.0645047513106275 no 3184 0.0381818898000105 4696 4118834 SGTC_741 4582-0002 126 µM -1.77898596576468 0.0637517776356122 no 3185 0.0376210314308088 4629 2912688 SGTC_293 4049-0273 38.5 µM -1.78406993883657 0.0631933455838064 no 3186 0.0372061506428008 4518 1380311 SGTC_1657 st012939 43.4 µM -1.79084156679212 0.0624554630617795 no 3187 0.0366593614011404 4618 24207257 SGTC_3168 9103419 49.47 µM -1.79460187143645 0.0620486254943862 no 3188 0.0363585773871913 4669 16649256 SGTC_2543 pimpinellin 60.67 µM -1.79999014789828 0.0614692613154301 no 3189 0.0359310969448128 4500 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo. SGTC_1927 st060202 13.8 µM -1.8012424404929 0.0613352179525035 no 3190 0.0358323378676718 4572 688887 SGTC_1961 st076550 68.7 µM -1.80412708575991 0.0610273191194284 no 3191 0.035605693237972 4636 1579337 SGTC_1174 0739-0097 51.1 µM -1.80526689262529 0.0609059929051076 no 3192 0.0355164638820006 4638 728447 SGTC_3226 9131256 49.47 µM -1.80903910562713 0.0605058059214519 no 3193 0.0352224641251131 4653 17178073 SGTC_2704 st078022 71.1 µM -1.81176673007393 0.0602177211938765 no 3194 0.0350111239258834 4659 54697681 SGTC_988 1497-1057 103 µM -1.81587809796726 0.0597855193432792 no 3195 0.0346945368649812 4629 3533044 SGTC_261 5-fluorouridine 15.376 µM -1.82083393171913 0.0592677786578981 no 3196 0.0343160523251859 4635 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_2546 rhodinyl acetate 100 µM -1.83847462543923 0.0574533243923434 no 3197 0.0329962487838062 4585 6708682 SGTC_604 1000-0114 314 µM -1.83888147446127 0.057411998881139 no 3198 0.03296631058668 4647 1572745 SGTC_100 0086-0128 49.5915 µM -1.84028738658742 0.0572693739862368 no 3199 0.032863028102836 4621 93297 SGTC_3260 9137109 49.47 µM -1.84317180789177 0.0569776324281862 no 3200 0.0326519648400015 4640 17478346 SGTC_742 0kpi-0133 140 µM -1.84485370470996 0.0568080597186805 no 3201 0.0325294113336752 4659 2728852 SGTC_826 1683-5028 118 µM -1.84561789137095 0.0567311441046377 no 3202 0.0324738534164568 4664 722377 SGTC_1998 st075797 76.8 µM -1.84627335130189 0.0566652372447152 no 3203 0.0324262625403096 4638 24208315 SGTC_3127 9126946 49.47 µM -1.84686254623796 0.0566060448611002 no 3204 0.0323835320810769 4596 27243249 SGTC_3004 9076122 71.4286 µM -1.84784447615887 0.0565075053417274 no 3205 0.0323124223630748 4627 44782551 SGTC_809 3998-0021 90 µM -1.85084724033429 0.0562070078054989 no 3206 0.0320957663593295 4612 715485 SGTC_285 1486-1325 46 µM -1.85348229470739 0.0559443475653088 no 3207 0.0319066307811669 4664 22310230 SGTC_2763 lisinopril 49.32 µM -1.86951148253478 0.0543673706254404 no 3208 0.0307758438113401 4571 5362119 A lysine-analog of enalapril and an ACE inhibitor. SGTC_762 1165-0429 115 µM -1.87075891291039 0.0542461363484689 no 3209 0.030689252470976 4661 5967793 SGTC_656 4090-1979 187 µM -1.87488035887935 0.0538471048595508 no 3210 0.0304045923555049 4675 22330961 SGTC_2887 9044784 58.44 µM -1.87769451972265 0.0535759803901176 no 3211 0.0302114834290767 4575 6465546 SGTC_594 1487-1584 10.8 µM -1.88099200539361 0.0532596682940032 no 3212 0.0299865031828493 4641 5013332 SGTC_2545 solidagenone 89.61 µM -1.88615251558638 0.0527676182788292 no 3213 0.0296372026099878 4621 6708572 An anti ulcer agent SGTC_474 dl-dihydrosphingosine 5 µM -1.88878744855147 0.0525177743983755 no 3214 0.0294601576410754 4627 3058739 A sphingolipid protein kinase C inhibitor. SGTC_2477 5967686 25.23 µM -1.89796326207093 0.0516550467039098 no 3215 0.0288504608603805 4637 776118 SGTC_961 1252-1571 372 µM -1.8993261229354 0.0515278744069389 no 3216 0.0287608051243647 4664 6813498 SGTC_2536 dehydroabietamide 32.04 µM -1.90644067691778 0.0508680330954404 no 3217 0.0282965277332685 4665 3983547 SGTC_1619 st003326 88.7 µM -1.91010165521976 0.0505311256942679 no 3218 0.0280600629694558 4642 2849032 SGTC_2402 5553605 200 µM -1.9106968874721 0.0504765168805203 no 3219 0.0280217725206218 4673 6758546 SGTC_257 daunorubicin 18.5 µM -1.91513260223501 0.050071047321601 no 3220 0.0277377974990083 4683 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_3217 9129673 49.47 µM -1.9218391949987 0.0494629324819695 no 3221 0.0273129973863953 4626 17248312 SGTC_1324 1418-0026 34.4 µM -1.92273977598261 0.0493817239094679 no 3222 0.0272563694059283 4687 1372513 SGTC_466 geldanamycin 89.2 µM -1.92931472248979 0.048792058439498 no 3223 0.0268459015643343 4700 5288382 HSP90 inhibitor. SGTC_649 1123-0311 367 µM -1.93375367615286 0.048397148533801 no 3224 0.026571710413636 4574 693629 YIL048W NEO1 SGTC_3224 9130643 49.47 µM -1.93692961064811 0.0481161746341845 no 3225 0.0263769741440361 4647 17644395 SGTC_2985 9022375 71.43 µM -1.94152725769924 0.0477117365309283 no 3226 0.0260971782522987 4655 4939335 SGTC_2374 9071832 200 µM -1.95672646247284 0.0463940619644049 no 3227 0.0251898184748354 4635 17381698 SGTC_1327 1436-0082 2.18 µM -1.96160839172594 0.0459770829209846 no 3228 0.0249040472603973 4692 15992205 SGTC_1142 3253-1408 9.78 µM -1.96540874697748 0.0456545727598313 no 3229 0.024683473961108 4670 256655 SGTC_297 0986-0032 24 µM -1.9676284142253 0.0454670476746347 no 3230 0.0245554039640159 4653 2847425 SGTC_1714 st033236 13.627 µM -1.96894228094234 0.0453563398776241 no 3231 0.0244798597704941 4653 2916566 SGTC_2857 9024691 58.44 µM -1.9717792334285 0.0451180347859237 no 3232 0.0243174069923678 4669 16478292 SGTC_1832 st054113 55 µM -1.98967424853393 0.0436379792175822 no 3233 0.0233134155997687 4705 1251267 SGTC_156 3474-0145 5.642 µM -1.99028608368549 0.0435880768383227 no 3234 0.0232797150595236 4616 2265471 SGTC_3195 9113082 49.47 µM -1.99141630157794 0.0434960153487021 no 3235 0.0232175692676034 4648 17018038 SGTC_1596 piperlongumine 63 µM -2.00164583403836 0.0426698927581948 no 3236 0.022661417906503 4692 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_3339 9145883 14.936 µM -2.00564658482736 0.0423502683590894 no 3237 0.0224469839639675 4633 2030670 SGTC_3012 9080433 71.4286 µM -2.00579528449739 0.042338426011216 no 3238 0.0224390469917471 4679 17688859 SGTC_3152 9099253 49.47 µM -2.01221742908908 0.0418295214632255 no 3239 0.0220985110067032 4543 25236131 SGTC_1835 st008666 49.2 µM -2.01355778633389 0.0417239359652122 no 3240 0.0220279911100092 4666 690455 SGTC_102 gallobenzophenone 83.616 µM -2.01852077668452 0.0413348586087828 no 3241 0.0217685262833091 4683 70837 SGTC_1400 3771-8998 51.5 µM -2.01959807260049 0.0412507928383131 no 3242 0.0217125476239992 4677 670767 SGTC_251 melphalan 456.522 µM -2.02432127528247 0.0408838566982801 no 3243 0.0214685529837787 4711 460612 A DNA alkylator. SGTC_968 1309-0633 340 µM -2.04252031341347 0.0394946941276308 no 3244 0.0205499732727905 4716 3761976 SGTC_779 1360-0071 233 µM -2.05180137383052 0.0388011794874588 no 3245 0.020094484873857 4704 7566 SGTC_2960 9079389 5.97 µM -2.05976000312628 0.0382144112221484 no 3246 0.0197107449940502 4657 16457355 SGTC_1646 st011709 75.6 µM -2.06310185841933 0.0379701919716661 no 3247 0.0195514758268443 4672 5757843 SGTC_1744 st037937 38.9 µM -2.06674542473736 0.0377053765480336 no 3248 0.019379074218362 4702 1016152 SGTC_2876 9059903 25.97 µM -2.06897158048682 0.0375443222106266 no 3249 0.0192743768222528 4694 6916095 SGTC_1284 0929-0043 16 µM -2.06967478685894 0.0374935646675712 no 3250 0.0192414046901449 4704 1239883 SGTC_116 0155-0182 31.788 µM -2.07325535837834 0.0372359868870831 no 3251 0.0190742604488103 4589 771486 SGTC_2758 dehydroepiandrosterone 69.35 µM -2.07602939593013 0.0370374247556554 no 3252 0.0189456161570397 4660 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem] SGTC_2225 6654152 15.4 µM -2.07625335951326 0.0370214315523595 no 3253 0.018935262255315 4683 97582 YGR029W | YLR033W ERV1 | RSC58 SGTC_1191 1487-1166 10.6 µM -2.07971622507701 0.0367748665033076 no 3254 0.0187757844997407 4696 3955771 SGTC_637 1181-0519 7.26 µM -2.08369461349106 0.036493254304767 no 3255 0.0185939772544522 4708 6252091 YGR060W ERG25 SGTC_582 0987-0078 156 µM -2.08931627263694 0.0360983331794283 no 3256 0.0183396312603247 4722 1625765 SGTC_3218 9131285 49.47 µM -2.10482236367367 0.0350271416288795 no 3257 0.0176533868562251 4661 17156417 SGTC_1433 4060-0023 7.6 µM -2.10515385668569 0.0350045293749613 no 3258 0.0176389587122764 4735 3840627 SGTC_1103 duloxetine 36.1 µM -2.11172589458922 0.0345586963539533 no 3259 0.0173549833279521 4731 60835 A selective serotonin reuptake inhibitor. SGTC_953 1188-0045 9.7 µM -2.11859570491778 0.0340976601761792 no 3260 0.0170623245149588 4673 6144426 SGTC_3158 9100007 49.47 µM -2.12399931045426 0.0337385853929083 no 3261 0.0168351006164359 4714 19297233 SGTC_3069 9117009 49.47 µM -2.12596754569595 0.0336085697677503 no 3262 0.0167529809645289 4715 41904981 SGTC_1565 sinapyl alcohol 95.1 µM -2.12622042922911 0.0335918949862929 no 3263 0.0167424549191937 4696 5280507 A phenol propionate derived from cinnamic acid. SGTC_1622 st003707 19.4 µM -2.13413980514648 0.0330731385330475 no 3264 0.016415669178503 4716 10140899 SGTC_3180 9109287 49.47 µM -2.13563895120911 0.0329756842767731 no 3265 0.0163544269839872 4725 18891271 SGTC_1880 MG-132 525 µM -2.1373791608512 0.0328628562382061 no 3266 0.0162835824855515 4686 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1 SGTC_3055 9094636 49.47 µM -2.13910005935361 0.0327515933874233 no 3267 0.016213782806545 4705 25236176 SGTC_605 1315-0399 119 µM -2.13956095896522 0.0327218472035804 no 3268 0.0161951322825524 4744 24020461 SGTC_1277 0873-0036 22 µM -2.14473118979139 0.0323896876422273 no 3269 0.0159871728186262 4748 5965735 SGTC_449 xestospongin c 11.1929 µM -2.14900827664005 0.0321170149308583 no 3270 0.0158168719299405 4723 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1 SGTC_288 1315-0019 35.1 µM -2.15269195284067 0.0318836948488307 no 3271 0.0156714481777905 4725 6811474 SGTC_2916 7875993 68.79 µM -2.16759048473677 0.030954275876535 no 3272 0.0150949291830836 4645 1299250 SGTC_1304 1165-0502 251 µM -2.17345632914783 0.0305945501416903 no 3273 0.0148729946188607 4715 767425 SGTC_2520 obtusaquinone 4.71 µM -2.1890723778176 0.0296537351662877 no 3274 0.0142957899099343 4739 5967872 SGTC_1552 6-methylflavone 10.6 µM -2.18907654042077 0.0296534876209442 no 3275 0.0142956386599653 4712 689013 SGTC_1172 0370-0043 85 µM -2.19178041836242 0.029493052983073 no 3276 0.0141976828499952 4724 376585 SGTC_97 0535-0701 19.132 µM -2.19223807943263 0.0294659690902313 no 3277 0.0141811601017127 4654 2832013 YGL099W LSG1 SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM -2.19981494657696 0.0290205707651296 no 3278 0.0139100135447807 4703 1241132 A phosphatase inhibitor. SGTC_626 0214-0009 33 µM -2.20245597778817 0.0288666413668431 no 3279 0.0138165577395713 4739 3437874 SGTC_2799 7812892 81.82 µM -2.21581628338664 0.028098316929984 no 3280 0.0133520434018347 4720 20205235 SGTC_3136 9095672 49.47 µM -2.23085558305099 0.0272538860538554 no 3281 0.0128453483619891 4645 17217380 SGTC_287 k060-0039 29.6 µM -2.24399545983446 0.026533532872233 no 3282 0.0124163467318055 4755 5861974 SGTC_1507 4075-3230 155 µM -2.25545835308653 0.0259181731424039 no 3283 0.0120522867830368 4709 659771 SGTC_3249 9135183 49.47 µM -2.25965828431806 0.025695718623411 no 3284 0.0119212336119264 4708 4902779 SGTC_1453 4237-0541 195 µM -2.27425276610347 0.0249350931431511 no 3285 0.0114753966629138 4731 739892 SGTC_2983 9022671 12.99 µM -2.27992706970627 0.0246445046465797 no 3286 0.0113060071359538 4719 6405161 SGTC_311 1315-0136 58 µM -2.28805406254794 0.0242332639915543 no 3287 0.0110671864821577 4747 6759207 SGTC_1897 st060201 15 µM -2.29765183426775 0.0237550366369162 no 3288 0.0107908064841676 4734 611878 SGTC_2380 9035439 200 µM -2.31137487132755 0.0230850622366146 no 3289 0.0104060788531556 4751 6462575 SGTC_3062 9077494 49.47 µM -2.33408925663175 0.0220111034004712 no 3290 0.00979552436436108 4691 16459633 SGTC_2958 9077254 16.72 µM -2.33629814528508 0.0219089524876599 no 3291 0.00973785406157995 4728 16457351 SGTC_3177 9107506 49.47 µM -2.33706979720201 0.0218733616234965 no 3292 0.00971777757817491 4750 8897194 SGTC_588 3970-1144 52.9 µM -2.34218539351988 0.0216386479025208 no 3293 0.00958559462705542 4692 1888707 SGTC_562 3772-2733 112 µM -2.34335714086313 0.0215851863933536 no 3294 0.00955553976376446 4715 2876874 YIL048W NEO1 SGTC_2491 paeonol 100 µM -2.35425402128672 0.021093335689937 no 3295 0.0092799614598438 4742 11092 Increases levels of cortical cytochrome oxidase. SGTC_1203 3992-3522 103 µM -2.35520660858191 0.0210507932399272 no 3296 0.00925620472739391 4722 5322312 SGTC_111 0083-0039 52.457 µM -2.3627387945068 0.0207169564392058 no 3297 0.00907022517613155 4741 759313 SGTC_1644 st010134 20.9 µM -2.3660871400457 0.0205699989404347 no 3298 0.00898860627186139 4738 3818134 SGTC_1603 st002045 67.8 µM -2.3834099085986 0.019823738198481 no 3299 0.00857654122698568 4761 5887985 SGTC_1718 roemerine 11.9335 µM -2.40710844194164 0.0188401269568898 no 3300 0.00803969725379839 4428 235224 An aporphine alkaloid with mutagenic activity. SGTC_1332 1480-0653 17.5 µM -2.40948806811255 0.0187436945968325 no 3301 0.00798745920988719 4760 5749438 SGTC_1680 diphenhydramine 100 µM -2.4110490196929 0.0186806667414532 no 3302 0.00795335517747418 4722 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1 SGTC_2909 7941780 10.49 µM -2.41494100652693 0.0185243018599812 no 3303 0.007868879208392 4734 1243215 SGTC_2428 5615643 7.78 µM -2.44201678662505 0.0174670493084899 no 3304 0.00730273373645099 4743 2253075 SGTC_1877 wortmannin 25 µM -2.44215367157683 0.0174618379481931 no 3305 0.00729996521849639 4762 312145 A covalent inhibitor of PI 3-kinase. SGTC_1983 st071813 46.9 µM -2.45106585318633 0.0171253864513771 no 3306 0.00712169461457323 4780 11838595 SGTC_1302 1159-0335 255 µM -2.45561065308467 0.0169559552208715 no 3307 0.00703227228049181 4768 649284 SGTC_2754 granisetron 64.02 µM -2.45908625692393 0.0168273528574875 no 3308 0.00696455734301556 4731 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients. SGTC_2269 7935389 174.42 µM -2.48718374649617 0.0158180053992325 no 3309 0.00643794383438934 4752 97605 SGTC_2182 6325192 200 µM -2.51066588608999 0.0150147209715608 no 3310 0.00602518448539654 4767 736248 SGTC_3308 9128332 17.569 µM -2.53745043227915 0.0141415099596269 no 3311 0.00558315898561315 4739 17332805 YDL196W YDL196W SGTC_1660 st012960 28.1 µM -2.56704285981141 0.0132279786506668 no 3312 0.00512849668252976 4778 24207266 SGTC_1649 st011737 51.3 µM -2.58820849577344 0.012606276929972 no 3313 0.00482382828963251 4760 1761035 SGTC_581 0958-0271 211 µM -2.59829788595107 0.012318930139546 no 3314 0.004684359009042 4774 4591145 SGTC_1743 st037606 46.3785 µM -2.60256679617885 0.0121990700072689 no 3315 0.00462643942771391 4736 590142 YLR208W | YDL195W SEC13 | SEC31 SGTC_922 1866-0035 480 µM -2.606630255243 0.0120859186486523 no 3316 0.00457190192533325 4723 3156169 SGTC_2279 7948423 32.93 µM -2.61409325620636 0.0118804722145435 no 3317 0.00447323067728674 4744 1247112 SGTC_473 2-arachidonoylglycerol 10 µM -2.64358178771499 0.011098048162895 no 3318 0.0041016972072583 4692 5282280 An endocannabinoid. SGTC_3155 9099265 49.47 µM -2.66800519603453 0.0104843354648016 no 3319 0.00381515390145827 4761 25236499 SGTC_327 1273-0057 3.96 µM -2.71712905721427 0.00933894455883366 no 3320 0.00329254623423518 4755 3108138 SGTC_2445 5742597 35.57 µM -2.71748216904563 0.00933112420242105 no 3321 0.0032890349866494 4768 1774255 SGTC_201 4262-0159 12.803 µM -2.73043296536283 0.00904823406068826 no 3322 0.0031625597571846 4789 1341029 SGTC_2519 cryptotanshinone 88.04 µM -2.73412046925099 0.00896907248336394 no 3323 0.00312735778338257 4769 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE) SGTC_381 3461-2219 42.7 µM -2.76338812609341 0.00836199698677 no 3324 0.00286023493610162 4773 2883159 SGTC_862 0452-0056 10.2 µM -2.78717702238458 0.00789544883093227 no 3325 0.00265847127510921 4774 1575396 YLR359W | YHR072W ADE13 | ERG7 SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM -2.78936274029981 0.00785375341540204 no 3326 0.00264059386396658 4749 6728940 SGTC_2549 cedrol 20.94 µM -2.8074034197022 0.00751693732819092 no 3327 0.00249713266314049 4775 6708665 A sedative which affects the nervous system. SGTC_217 ketoconazole 989 nM -2.82267739090032 0.00724178902445435 no 3328 0.00238122336613858 4685 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4 SGTC_2752 diclazuril 33.15 µM -2.82879111000701 0.00713416871586264 no 3329 0.0023362092615264 4734 456389 An antifungal agent for coccidioides. YHR062C RPP1 SGTC_699 0375-0592 111 µM -2.88294860179375 0.00624079589489583 no 3330 0.00196985859234588 4802 762578 SGTC_1291 0993-0025 5.79 µM -2.93332241996984 0.00550028057634047 no 3331 0.00167677717210597 4784 4353356 SGTC_2975 9084847 53.72 µM -2.93564012730802 0.00546817130611343 no 3332 0.00166430117262132 4768 27211724 SGTC_3081 9117243 49.47 µM -2.94356657692774 0.00535961446867805 no 3333 0.00162227014763036 4758 45595589 SGTC_1280 0880-0253 10.1 µM -2.96463033401254 0.00508039050364014 no 3334 0.00151523421175438 4791 6836607 SGTC_569 4130-2812 160 µM -3.01635765987994 0.00444889328867902 no 3335 0.00127915650056284 4772 743552 SGTC_705 1124-0212 310 µM -3.03086715427849 0.00428483195299057 no 3336 0.00121926255682011 4787 9554485 SGTC_2811 7967822 32.47 µM -3.03569779378838 0.00423142365823061 no 3337 0.00119989881578786 4784 2232244 SGTC_570 0987-0065 62.6 µM -3.15767987368688 0.00306571795067901 no 3338 0.000795150458234492 4780 3104428 SGTC_335 4077-0256 27.6 µM -3.1647820645148 0.00300774546521619 no 3339 0.000775995754123878 4739 3121989 SGTC_2834 9001755 58.44 µM -3.17432711058931 0.00293138880845703 no 3340 0.000750921659454969 4713 2989575 SGTC_193 1273-0060 1.558 µM -3.17870055844208 0.00289699024329866 no 3341 0.000739684168440036 4770 2847393 YHR072W ERG7 SGTC_1054 3429-0080 167 µM -3.19260390769747 0.00279004014111515 no 3342 0.00070498103036111 4793 1162877 SGTC_2533 agelasine 13.65 µM -3.25749397418713 0.00233650412583475 no 3343 0.000562003223955096 4791 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase. SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM -3.29555898262315 0.00210261623755781 no 3344 0.000491130406837814 4776 6708760 SGTC_151 3013-0144 2.285 µM -3.34205796093767 0.00184581923945964 no 3345 0.000415798468829639 4685 906558 YHR107C CDC12 SGTC_1741 st038134 10.228 µM -3.42509671691827 0.00145706294114517 no 3346 0.00030729029760557 4788 1272587 SGTC_893 0958-0369 48.9 µM -3.54982832841619 0.00101187274584607 no 3347 0.000192741219914232 4738 6819948 SGTC_123 0083-0120 66.675 µM -3.55063174719985 0.00100946216012253 no 3348 0.000192153866622256 4794 16001701 SGTC_314 1671-0008 2.74 µM -3.79926854007095 0.000471761613368919 yes 3349 7.25618884415318e-05 4768 3913060 SGTC_2452 5863136 48.41 µM -3.85140483651431 0.00039991202195277 yes 3350 5.87210835234275e-05 4797 2184096 SGTC_119 0121-0043 24.815 µM -3.88797965839778 0.000355720647622196 yes 3351 5.05410478024824e-05 4803 1092378 SGTC_117 lucigenin 22.078 µM -4.51203546730561 4.14533732896376e-05 yes 3352 3.21042239426556e-06 4799 65100 An acridine derivative; a dye stuff and potential carcinogen. SGTC_2050 5263056 171 µM -4.71679341204615 1.92309709036007e-05 yes 3353 1.19795374675878e-06 4807 763468 YGL055W OLE1 SGTC_1747 st037496 66.6 µM -4.90213142577538 9.34113751131666e-06 yes 3354 4.74011868780009e-07 4802 723305