SGTCid condition conc unit RPL9A|YGL147C.score RPL9A|YGL147C.strain.pval RPL9A|YGL147C.strain.significant RPL9A|YGL147C.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene
SGTC_880 0833-0487 87.2 µM 4.54631370437611 3.07316789772775e-06 yes 1 2.72968239689944e-06 12 76075
SGTC_3118 9124250 49.47 µM 4.42965705195752 5.28471523781093e-06 yes 2 4.71915292995182e-06 8 1504786
SGTC_1374 2889-5571 141 µM 4.348251430113 7.65568407181479e-06 yes 3 6.86136159259646e-06 29 2853281
SGTC_708 3448-5400 146 µM 4.20107829927851 1.47249216802018e-05 yes 4 1.32823344668744e-05 38 3462195
SGTC_974 1326-0144 138 µM 4.17131386272214 1.67656058896253e-05 yes 5 1.5142419255196e-05 35 5411856
SGTC_1759 st043059 70 µM 4.15392741162192 1.80790741942924e-05 yes 6 1.63408444170303e-05 22 669426
SGTC_2020 4017018 200 µM 4.1462134992194 1.8692602781753e-05 yes 7 1.69009332260232e-05 14 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope.
SGTC_840 0245-0196 390 µM 3.98818545905727 3.65770481298616e-05 yes 8 3.32903029094001e-05 12 3827528
SGTC_2434 5670830 169.91 µM 3.98409326326576 3.72067787413471e-05 yes 9 3.38691339397339e-05 24 1549830
SGTC_1232 0279-0259 161 µM 3.93763611343368 4.51131023697092e-05 yes 10 4.11441279405073e-05 18 1560000
SGTC_93 0109-0045 59.227 µM 3.90940655133631 5.06663108059213e-05 yes 11 4.62615690666832e-05 48 88733
SGTC_2358 9037157 4 µM 3.8702638703988 5.94410639709583e-05 yes 12 5.43588076560082e-05 33 2388925
SGTC_1381 2324-0066 62.1 µM 3.82923226119574 7.01663275463063e-05 yes 13 6.4271823470421e-05 32 10885928
SGTC_1041 0206-0046 107 µM 3.78113874548488 8.50539325772155e-05 yes 14 7.80563173408938e-05 39 50494
SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM 3.67046135579391 0.000131346656363109 yes 15 0.000121056536724559 34 1377
SGTC_497 capsazepine 133 µM 3.65996765447186 0.00013678975898248 yes 16 0.00012612354374902 18 2733484 A calcium channel blocker.
SGTC_2932 9016711 44.54 µM 3.62196919368041 0.00015831959041366 yes 17 0.000146184472590753 57 7117328
SGTC_994 3910-0338 138 µM 3.56162669492489 0.000199130423054839 yes 18 0.00018428209020205 63 3479481
SGTC_2793 7325131 81.82 µM 3.50609713774385 0.00024518254101403 yes 19 0.000227364616776264 24 4176441
SGTC_2850 9015429 58.44 µM 3.48231961590677 0.000267790609225504 yes 20 0.000248544998665439 26 6457570
SGTC_2770 toltrazuril 17.5 µM 3.45931207819467 0.000291502668873117 yes 21 0.000270778515957372 42 68591 Kills coccidiodes.
SGTC_2852 9023854 51.95 µM 3.45177615696384 0.000299684918756293 yes 22 0.00027845476594321 41 19798528
SGTC_118 0083-0097 135.343 µM 3.44123588212035 0.000311488216263739 yes 23 0.000289531743377623 200 5207356
SGTC_174 3553-0389 74.3 µM 3.43557540910099 0.000318004093575455 yes 24 0.000295648438656221 36 738071
SGTC_1296 1068-0102 11.9 µM 3.40207703887013 0.000359232823634615 yes 25 0.000334378916200918 17 767053
SGTC_3119 9125183 49.47 µM 3.37290764177932 0.00039912392605432 yes 26 0.000371894484614792 17 22695334
SGTC_1258 0671-0043 57.1 µM 3.32993151597125 0.000465435150635185 yes 27 0.000434336733562416 51 4298767
SGTC_1845 st056753 3.01 µM 3.29493551799146 0.000526823156893907 yes 28 0.000492221332365822 62 5375839
SGTC_2481 5478948 45.16 µM 3.23014953492154 0.000660646060328268 yes 29 0.000618627442806966 72 77792
SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM 3.19513958738784 0.000745398115961406 yes 30 0.000698816126363294 32 17037758
SGTC_69 0096-0274 206.684 µM 3.15463897227217 0.000855881990948709 yes 31 0.000803484120742371 91 6741392
SGTC_830 4076-0286 57.8 µM 3.1279277980201 0.000936788821243643 yes 32 0.000880217106774681 123 6866659
SGTC_791 1348-1292 225 µM 3.07876622174381 0.00110431185470674 no 33 0.00103929860522962 92 5437054
SGTC_432 NS 1619 61.3 µM 3.07143923875386 0.00113150794666732 no 34 0.00106514758399386 65 4552 A K+/calcium channel activator.
SGTC_2062 5245942 200 µM 3.06771091408031 0.00114558094803264 no 35 0.00107852589792325 54 1376160
SGTC_1899 st063254 59.6 µM 3.06388800516036 0.0011601772922329 no 36 0.00109240341879041 40 3093813
SGTC_87 0100-0052 35.5 µM 3.0608824619161 0.00117177220979228 no 37 0.00110342854172384 211 200187 YGR083C | YDR527W GCD2 | RBA50
SGTC_1533 dihydroergotamine mesylate 29.4 µM 3.0193885228073 0.00134306989216074 no 38 0.00126642743220979 44 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release.
SGTC_1444 4112-3581 28 µM 3.01326553895232 0.00137020081887616 no 39 0.00129226332072959 46 2877249
SGTC_3210 9128157 49.47 µM 2.98122641094936 0.00152050621928723 no 40 0.00143548223873082 110 17590849
SGTC_3117 9124945 49.47 µM 2.96850315184245 0.00158425719019231 no 41 0.00149627016587992 30 17592065
SGTC_2156 5649887 115 µM 2.94903765230679 0.00168651600143873 no 42 0.001593825686815 57 54680440 YKL052C | YBR257W ASK1 | POP4
SGTC_419 nsc-638432 893 µM 2.93627618389177 0.00175678049435228 no 43 0.00166089215563114 48 368090
SGTC_826 1683-5028 118 µM 2.9160584362787 0.0018735667840389 no 44 0.00177242050244386 59 722377
SGTC_1430 4049-0248 69.1 µM 2.9126664668766 0.0018938375608983 no 45 0.00179178568588642 73 22774488
SGTC_155 k072-0202 43.6 µM 2.90798644921851 0.0019221330929498 no 46 0.00181882049872141 51 5857737
SGTC_800 3448-7362 155 µM 2.88617305580359 0.00205915192209263 no 47 0.00194978835544823 293 15991913
SGTC_2094 5332512 191.667 µM 2.87286054166283 0.00214706912817638 no 48 0.00203386817637043 79 755774
SGTC_576 1073-0113 22.7 µM 2.87033797814387 0.00216410704006862 no 49 0.00205016635182324 161 5439563
SGTC_3343 9148379 18.9835 µM 2.84065707942586 0.00237398806560617 no 50 0.00225103474686432 44 1955036
SGTC_1666 st014829 29 µM 2.82634306725158 0.00248164859612819 no 51 0.00235414041292894 75 3858230
SGTC_2268 7933382 153.85 µM 2.82415178833731 0.00249851414519165 no 52 0.00237029642073782 94 935025 YOR257W CDC31
SGTC_2335 9018011 154.17 µM 2.79735921373046 0.00271327289497566 no 53 0.0025761107932398 86 6458208
SGTC_1889 st059080 5.18 µM 2.78927527325982 0.00278126743346078 no 54 0.00264130718282251 85 176925 Isolated from Daphnopsis sellowiana.
SGTC_1456 k015-0012 13 µM 2.78679749350428 0.00280241392919272 no 55 0.00266158663043282 92 2989616
SGTC_2267 7931562 200 µM 2.76804859338833 0.00296718536169139 no 56 0.00281965233373789 70 934880
SGTC_2797 7859098 81.82 µM 2.7673525734365 0.00297346692721678 no 57 0.00282567998042978 96 972681
SGTC_2351 9026858 72.31 µM 2.76444752618061 0.00299981450772022 no 58 0.00285096386448062 81 1409300
SGTC_1466 k213-0079 57.5 µM 2.76128139284173 0.00302876942620564 no 59 0.00287875231768577 77 3657981
SGTC_759 3486-0358 89.3 µM 2.7601326902762 0.00303933662089179 no 60 0.00288889445267041 74 875103
SGTC_2433 5607874 27.82 µM 2.75885715542534 0.00305110947886278 no 61 0.00290019415814411 90 2252428
SGTC_2296 7971656 126.45 µM 2.74930234789179 0.00314061214146119 no 62 0.0029861134672399 115 666570
SGTC_2066 5222451 176 µM 2.73832719491826 0.00324633078940768 no 63 0.00308763020193936 111 2281147
SGTC_770 0389-1121 67.2 µM 2.73173172054026 0.00331139141998284 no 64 0.00315012098892852 94 6753108
SGTC_1898 st060199 18.6 µM 2.73155415782072 0.00331315906899111 no 65 0.00315181898503988 57 688866
SGTC_2629 bisabolol 100 µM 2.70567727238011 0.00358001972453087 no 66 0.00340826276388973 101 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer.
SGTC_180 1486-1293 102.781 µM 2.69992123716102 0.00364194162755255 no 67 0.00346779467273045 122 4140536
SGTC_1334 1486-0610 236 µM 2.69593451361661 0.00368539131920588 no 68 0.00350957322984643 86 3742339
SGTC_3341 9147222 25.867 µM 2.69408457264051 0.00370571058221165 no 69 0.00352911263402698 67 1939759
SGTC_786 4544-0069 423 µM 2.68510863049286 0.00380573356756649 no 70 0.00362531179507657 122 748821 YLR208W SEC13
SGTC_1336 1486-0901 104 µM 2.67215630503568 0.00395433418666896 no 71 0.0037682767178382 76 5006114
SGTC_648 0375-0473 33.3 µM 2.66575340927156 0.00402969620657999 no 72 0.00384080071787522 87 1713139
SGTC_692 k241-0027 77.8 µM 2.6613580769991 0.00408217092852077 no 73 0.00389130712408432 70 3600480
SGTC_2432 5630864 12.22 µM 2.64212213045886 0.00431909022316553 no 74 0.00411941706098301 125 5714970
SGTC_78 0336-0123 156.75 µM 2.63622231470408 0.00439417875436106 no 75 0.00419173928799514 83 6765896
SGTC_832 4083-0019 164 µM 2.62419942249443 0.00455081746973972 no 76 0.00434264576673737 253 1990758
SGTC_1442 4112-3290 3 µM 2.61925742405674 0.00461663624803055 no 77 0.00440607104873021 87 704353
SGTC_7 0192-1582 4.227 µM 2.61471646708276 0.00467786140380996 no 78 0.00446507764336898 179 252616
SGTC_904 1141-0088 396 µM 2.61328106410044 0.00469736488527775 no 79 0.00448387597470138 90 1378119
SGTC_2212 7123476 200 µM 2.61044946976127 0.00473605187398876 no 80 0.0045211664719295 43 1085715
SGTC_57 miconazole 162.5 nM 2.60969388366141 0.00474642307336232 no 81 0.00453116380401135 100 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_2082 5219693 150 µM 2.60341202339014 0.0048334352960662 no 82 0.00461504766887275 114 2834649
SGTC_1040 k898-0338 155 µM 2.5968354625888 0.0049260504032523 no 83 0.00470434908285859 96 20969351
SGTC_1196 1588-0294 184 µM 2.58056191873253 0.00516205566393465 no 84 0.00493198327343407 83 6144269
SGTC_1025 k007-0731 70 µM 2.57581790784922 0.00523272389330355 no 85 0.00500016478130745 91 6256118
SGTC_1953 st076800 12.1 µM 2.55542367998776 0.00554642230464861 no 86 0.00530293082362298 157 297591
SGTC_1198 1612-1005 86.7 µM 2.55073422129761 0.00562087471281946 no 87 0.00537481332753162 97 6998509
SGTC_3315 9136395 68.55 µM 2.53910745212901 0.00580930886049098 no 88 0.00555678420979375 96 16876844
SGTC_2288 7946289 167.31 µM 2.51966140907715 0.00613701819793893 no 89 0.00587338846875241 129 1246052
SGTC_2385 9074692 200 µM 2.51474136015951 0.00622248542005341 no 90 0.00595598677672862 131 17046906
SGTC_91 0417-1751 58.384 µM 2.51064259919511 0.0062944889914412 no 91 0.00602558191393242 167 6795624
SGTC_2453 5731132 22.18 µM 2.4927213849739 0.00661804958374836 no 92 0.00633841378103906 130 1362040
SGTC_622 1348-1566 26.3 µM 2.47246222937993 0.0070014520687737 no 93 0.00670929461922244 120 7340407
SGTC_1473 k844-0725 134 µM 2.4712866182186 0.0070242904439834 no 94 0.0067313934258035 114 54682906
SGTC_336 4111-0029 111 µM 2.47109892158371 0.00702794287143964 no 95 0.00673492764231255 86 3131175
SGTC_946 3434-1334 87.4 µM 2.45518868089719 0.00734370148683584 no 96 0.00704053296246286 132 4047976
SGTC_2447 5741742 33.78 µM 2.45443762259448 0.00735891149308127 no 97 0.00705525714278293 137 1776504
SGTC_2845 9003024 42.97 µM 2.43278039370625 0.00780961185120801 no 98 0.00749169268683338 176 2990173
SGTC_2443 5493264 126.67 µM 2.42084298228292 0.0080682770465994 no 99 0.00774228204543938 119 5340055
SGTC_2365 9042475 200 µM 2.40434380376048 0.00843817329906329 no 100 0.00810076409068737 147 6464479
SGTC_2806 7952793 58.44 µM 2.39472917676193 0.00866051952398825 no 101 0.00831632272806433 130 2972490
SGTC_1513 0337-0559 19 µM 2.38376447298383 0.00892034383329058 no 102 0.008568283019972 146 775073
SGTC_834 0312-0008 75.7 µM 2.37684791281472 0.00908773240148206 no 103 0.00873064297594281 172 6385573 YIL048W NEO1
SGTC_2172 5754775 163.918 µM 2.37402116113368 0.0091569308047169 no 104 0.00879777102049827 141 2263357
SGTC_1657 st012939 43.4 µM 2.37184608544846 0.00921048987950475 no 105 0.0088497310172912 103 24207257
SGTC_2658 polymyxin b sulfate 77.05 µM 2.36896542031779 0.00928184531517529 no 106 0.00891896057055652 160 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides. YIL048W NEO1
SGTC_3303 9125618 40.5795 µM 2.36449772606686 0.00939346913919572 no 107 0.00902726909376624 201 22695467
SGTC_1446 4239-0190 62 µM 2.33539439607479 0.0101497556195743 no 108 0.00976141345513445 174 1340085
SGTC_707 0865-0008 204 µM 2.33505515710287 0.0101588756251608 no 109 0.00977026975363176 111 723043
SGTC_403 arphamenine a 50 µM 2.3344716816741 0.0101745783380529 no 110 0.00978551859857032 149 5487158 An arginine aminopeptidase inhibitor.
SGTC_2840 9008771 71.43 µM 2.33144360112846 0.0102564117242586 no 111 0.00986499035554265 89 2992978
SGTC_248 streptozotocin 5.23457 mM 2.33067220564015 0.0102773500759633 no 112 0.0098853254320016 145 5300 DNA alkylating agent.
SGTC_1665 st014639 11.4 µM 2.32917743395874 0.0103180294870577 no 113 0.00992483393042877 162 981133 YIL048W NEO1
SGTC_2787 5284540 71.43 µM 2.32867206270682 0.0103318146160847 no 114 0.00993822261056061 163 736958
SGTC_395 anisomycin 6.25 µM 2.32153721488967 0.0105281539693732 no 115 0.0101289339975646 86 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_2061 5245884 80.95 µM 2.31759072567302 0.0106381451442512 no 116 0.0102357873610755 148 573863
SGTC_2204 7233102 200 µM 2.30921496570436 0.0108749037543229 no 117 0.0104658277549972 86 2172480
SGTC_2000 st075254 36.4 µM 2.30700130927838 0.0109382385048501 no 118 0.0105273735592324 102 17234175
SGTC_2902 5787006 60.46 µM 2.30036816806199 0.0111299443225989 no 119 0.0107136853256931 144 591003
SGTC_2241 6772625 37.8075 µM 2.29259853698752 0.0113582056742635 no 120 0.0109355643469343 144 2285411
SGTC_2150 5556613 200 µM 2.28639367937259 0.0115434069498933 no 121 0.0111156188873349 138 743190
SGTC_420 mitomycin C 81.9 mM 2.26402414853411 0.0122330260898697 no 122 0.0117863147833488 160 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_1176 0848-0131 83.3 µM 2.26236497118827 0.0122855695557789 no 123 0.0118374316398394 174 6769040
SGTC_653 0203-0016 55.2 µM 2.26215385709781 0.0122922692008278 no 124 0.0118439495340273 155 295302
SGTC_2099 5377090 177.372 µM 2.25555816350218 0.0125031819175352 no 125 0.0120491579025773 175 2243829
SGTC_1147 3809-1045 12.3 µM 2.25543648059456 0.012507102268926 no 126 0.0120529725411727 172 325925
SGTC_1861 st057647 17.4 µM 2.24675800402766 0.0127894620784603 no 127 0.0123277485123395 164 688668
SGTC_1502 4534-4282 27.7 µM 2.24171301749086 0.012956125473872 no 128 0.0124899630065592 136 3278949
SGTC_935 2996-0153 430 µM 2.23709588791627 0.0131102968682652 no 129 0.0126400368358716 143 23738523
SGTC_1614 st002383 48.6 µM 2.23214668962613 0.0132773146166941 no 130 0.0128026347341569 148 1947235
SGTC_1557 sumaresinolic acid 42.3 µM 2.23043441208637 0.0133355242517685 no 131 0.0128593085810125 164 9982268 A natural terpine and antifungal of unknown mechanisn.
SGTC_1617 st002906 78 µM 2.22475745447075 0.0135300944360774 no 132 0.0130487624772858 183 5150859
SGTC_1319 1306-0155 43.7 µM 2.21946682444047 0.0137136248491007 no 133 0.0132274909059165 214 3122360
SGTC_1003 4049-0218 100 µM 2.21934390229622 0.0137179143885114 no 134 0.0132316684877368 200 295161
SGTC_333 3486-0131 40.1 µM 2.21898075964776 0.0137305935186405 no 135 0.0132440167641393 132 6744690
SGTC_2423 st077119 87.2 µM 2.21776782824032 0.0137730163375034 no 136 0.0132853333829949 162 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae).
SGTC_932 2857-0803 154 µM 2.21685335251778 0.0138050752425183 no 137 0.0133165571446477 162 674898
SGTC_2771 fluoxetine 41.05 µM 2.21274207659029 0.013950001150414 no 138 0.0134577163632119 158 3386 A selective serotonin reuptake inhibitor.
SGTC_2104 5389443 200 µM 2.20709068673465 0.0141513569106524 no 139 0.0136538621541723 188 2244536
SGTC_1885 st057546 99.9 µM 2.20697790346857 0.0141554006679956 no 140 0.013657801557439 179 702008
SGTC_774 k060-0086 136 µM 2.20477339496686 0.014234641779709 no 141 0.0137349999334763 193 5911235
SGTC_1101 ebselen 5.29 µM 2.2002820915291 0.014397264691991 no 142 0.0138934435360531 168 3194 A potent scavenger of hydrogen peroxide and hydroperoxides.
SGTC_2140 5586273 200 µM 2.19414800618675 0.0146219527734302 no 143 0.0141123855109744 114 854421
SGTC_1340 1486-1359 257 µM 2.18677433045618 0.0148960339766546 no 144 0.0143795011339239 170 4309068
SGTC_3245 9134821 49.47 µM 2.18479027805787 0.0149705315560798 no 145 0.0144521136019899 180 17014901
SGTC_2003 4023581 200 µM 2.18066999521303 0.0151262644178943 no 146 0.0146039169312319 182 16641307
SGTC_1927 st060202 13.8 µM 2.17009871925346 0.0155322043509557 no 147 0.0149996841002631 158 688887
SGTC_495 decylubiquinone 155 µM 2.16918879509996 0.0155675787210245 no 148 0.0150341767353805 198 2971 A Co-enzyme Q analog. A free radical scavenger.
SGTC_1434 4073-0095 163 µM 2.15094369959706 0.0162916080911585 no 149 0.0157403218764066 149 24133745
SGTC_2307 7538926 6.34 µM 2.14505046616858 0.0165315521201168 no 150 0.0159744061180454 227 96582
SGTC_955 1216-0110 33 µM 2.14160015703684 0.0166734310918284 no 151 0.0161128355477798 260 3619719
SGTC_25 0118-0223 35.662 µM 2.13872793388409 0.0167923321847286 no 152 0.0162288544645376 177 5333628
SGTC_1530 rhein 70.4 µM 2.12779087963199 0.0172517536194267 no 153 0.0166772129448564 183 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death.
SGTC_2186 6124449 200 µM 2.1276724199807 0.0172567878346637 no 154 0.0166821265744292 181 3834182 YLR033W RSC58
SGTC_1260 0700-1617 7.75 µM 2.12210362690868 0.0174948668654877 no 155 0.0169145184530225 229 2853078
SGTC_1544 7-methoxy-4-methylcoumarin 105 µM 2.11846366338427 0.0176519947839209 no 156 0.0170679095682757 192 390807
SGTC_1360 1598-0022 39.8 µM 2.1135830785547 0.0178645659673151 no 157 0.0172754461867807 260 761525
SGTC_3213 9129884 49.47 µM 2.11071007973757 0.0179907158735531 no 158 0.0173986195374901 153 17190742
SGTC_891 0929-0073 133 µM 2.10991448661736 0.0180257834075457 no 159 0.0174328611105114 171 5603632
SGTC_2047 4141938 200 µM 2.09921679118527 0.0185029966944892 no 160 0.0178988972441594 149 3807862
SGTC_438 sphingosine 6.67 µM 2.09866171399571 0.0185280489816417 no 161 0.0179233659674553 159 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes.
SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM 2.09720519532681 0.0185939233711156 no 162 0.0179877073990049 237 6728940
SGTC_1329 1447-1697 50.6 µM 2.08592178589593 0.0191110286029986 no 163 0.0184928542518226 200 2840515
SGTC_3114 9122766 49.47 µM 2.08556150007214 0.0191277395251219 no 164 0.01850918092327 198 17176985
SGTC_1216 1165-0504 9.65 µM 2.08305211455819 0.0192444757931655 no 165 0.0186232367569654 189 6304004
SGTC_2022 5136654 200 µM 2.08088210697852 0.0193459119393336 no 166 0.0187223491545588 189 1713771
SGTC_334 1502-1024 68.5 µM 2.07310512421116 0.0197131836714326 no 167 0.0190812486173108 197 3296216
SGTC_1506 4226-2149 212 µM 2.06661276458936 0.020024305824439 no 168 0.0193853285282539 238 991114
SGTC_2174 5790901 200 µM 2.05864631339677 0.0204117503951975 no 169 0.0197640663365502 228 786020
SGTC_3300 9124615 50.48 µM 2.04019646667298 0.0213335050990328 no 170 0.0206653807690057 234 24824903
SGTC_882 0843-0131 351 µM 2.04014460446072 0.0213361449411521 no 171 0.020667962613329 209 5425421
SGTC_3048 9093155 49.47 µM 2.03919830300356 0.0213843612199006 no 172 0.0207151201079177 150 25236002
SGTC_1913 st060213 96.1 µM 2.0384531122689 0.0214223952433304 no 173 0.0207523196559701 253 688959
SGTC_2112 5488546 200 µM 2.03638348604625 0.0215283276414032 no 174 0.0208559311911943 221 600757
SGTC_2064 5220758 200 µM 2.01907106260276 0.0224319147439586 no 175 0.0217399170068342 255 788518
SGTC_1339 1486-1321 22.7 µM 2.012499058784 0.0227832036064134 no 176 0.0220836778989114 225 3469382
SGTC_2388 9080168 200 µM 1.99987212679767 0.0234711594843664 no 177 0.0227570368288571 159 15943073
SGTC_1972 st070201 17.4 µM 1.99825965222999 0.0235602579366173 no 178 0.0228442586770892 210 2829099
SGTC_290 2043-6722 48.1 µM 1.99041812985293 0.0239976127422313 no 179 0.0232724471963157 206 773758 YLR208W SEC13
SGTC_1977 st070720 65.3 µM 1.99000655411959 0.0240207552539813 no 180 0.0232951067588527 178 682188
SGTC_2763 lisinopril 49.32 µM 1.97448179154747 0.0249074915557754 no 181 0.0241634929326994 162 5362119 A lysine-analog of enalapril and an ACE inhibitor.
SGTC_652 0437-0092 114 µM 1.97039620294343 0.0251453608045577 no 182 0.0243964902091053 199 3091274
SGTC_3120 9124077 49.47 µM 1.96925769374875 0.0252119847551358 no 183 0.0244617533540329 182 18774327 YGL155W CDC43
SGTC_3338 9144300 39.5675 µM 1.9685236938726 0.0252550157671824 no 184 0.0245039063225393 239 4901274
SGTC_1600 coumarin 106 71.1 µM 1.95838697866445 0.0258556043745467 no 185 0.0250923107672674 248 100336 A hepatotoxic, DNA x-linker.
SGTC_3179 9107801 49.47 µM 1.95663322039268 0.0259607157304865 no 186 0.0251953031758931 210 4818259
SGTC_1919 st067113 52.3 µM 1.93746718061654 0.0271329086052549 no 187 0.0263441307177033 269 1268243
SGTC_2688 kanamycin b 96.69 µM 1.9361603315965 0.0272144184615082 no 188 0.0264240336131251 818 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis.
SGTC_1290 0986-0249 10.2 µM 1.93560711743729 0.0272489846291989 no 189 0.0264579189980739 191 53329
SGTC_1064 honokiol 6.76 µM 1.93192961210471 0.0274796962060149 no 190 0.0266840971267308 246 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis.
SGTC_14 0354-0009 295 µM 1.9276390802458 0.0277509227763978 no 191 0.0269500171836014 242 1713507
SGTC_874 0599-0792 117 µM 1.92728594660859 0.0277733451793306 no 192 0.026972002002641 279 765305
SGTC_1641 st009299 47.1 µM 1.92025294135128 0.0282230629129458 no 193 0.0274129786764731 161 4046054
SGTC_807 1315-0151 48 µM 1.91887050480817 0.0283121703742537 no 194 0.0275003621267357 280 4011080
SGTC_27 0485-0001 32.618 µM 1.91428204068265 0.0286096080438458 no 195 0.0277920639540367 150 2054479
SGTC_1532 4',5'-dihydroxyflavone 78.7 µM 1.90873080373133 0.0289729249994872 no 196 0.0281484136459252 237 165521
SGTC_608 k048-0125 159 µM 1.90452730138505 0.0292505795307019 no 197 0.0284207722468221 247 6817652 YLR060W | YFL022C FRS1 | FRS2
SGTC_3039 9090270 49.47 µM 1.89538928232982 0.0298618033710643 no 198 0.0290204237744288 193 17173750
SGTC_2436 5633522 8.09 µM 1.8721331378723 0.0314652846520574 no 199 0.030594093227267 276 5724242
SGTC_2476 5806916 10.51 µM 1.86558037953933 0.0319297311845349 no 200 0.0310500483974146 227 2870194
SGTC_2663 amphotericin b 100 µM 1.86225132787152 0.0321678481032247 no 201 0.0312838362783311 249 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_2108 5365811 200 µM 1.86043677116015 0.0322982538596622 no 202 0.0314118781650386 280 780283
SGTC_534 k292-0788 63.4 µM 1.86011813654785 0.0323211979698177 no 203 0.0314344068729896 288 4146317
SGTC_1590 st077108 57.8 µM 1.85442211704781 0.0327336289633379 no 204 0.0318393965154891 208 5489485
SGTC_1932 st074806 40.9 µM 1.84527056450585 0.0334053440170301 no 205 0.0324990950710668 307 17251235
SGTC_185 k048-0037 25.491 µM 1.84462286466761 0.0334533115054071 no 206 0.0325462092830162 229 6827589
SGTC_3255 9139072 49.47 µM 1.83909097992726 0.0338653076287818 no 207 0.0329509027519477 255 17646060
SGTC_1361 1608-0041 5.61 µM 1.83049401419156 0.0345138569329006 no 208 0.0335880505171629 277 X1361
SGTC_3116 9124943 49.47 µM 1.82934630137565 0.034601206604588 no 209 0.0336738732642558 270 41905195 YPL160W CDC60
SGTC_127 0180-0333 59.125 µM 1.82905772584713 0.0346231979410817 no 210 0.033695480501596 372 771601
SGTC_544 k015-0020 52.4 µM 1.82839329123984 0.0346738758368334 no 211 0.0337452737540292 265 3008304
SGTC_2362 9071156 126 µM 1.82539215246591 0.0349035388722007 no 212 0.0339709363447745 273 653133
SGTC_3270 9137563 49.47 µM 1.82062368927319 0.0352710140149693 no 213 0.0343320396488881 234 17015724
SGTC_147 4466-0538 29.23 µM 1.79748785770499 0.0370992566407903 no 214 0.0361291020311119 306 6742687 YHR072W ERG7
SGTC_911 3456-4043 236 µM 1.78774129036679 0.0378922959359954 no 215 0.0369088783879454 326 914281
SGTC_2721 ifenprodil 61.44 µM 1.78553261160316 0.0380739164972662 no 216 0.0370874832491153 289 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor.
SGTC_3231 9132313 49.47 µM 1.7851867600972 0.0381024202044277 no 217 0.0371155143988729 262 4905967
SGTC_1846 st056244 14.8 µM 1.78122493961894 0.0384301810179103 no 218 0.0374378554842468 315 5393182
SGTC_2532 xanthone 78.9 µM 1.78059475672153 0.0384825271908276 no 219 0.0374893384839169 285 7020 An insecticide.
SGTC_3336 9143619 71.43 µM 1.78045583744107 0.038494074341485 no 220 0.0375006953142008 309 45595730
SGTC_90 0870-0863 4.608 µM 1.7801346704248 0.038520780971527 no 221 0.0375269618878854 315 1738164
SGTC_2504 purpurogallin 52.29 µM 1.77529136695509 0.0389253596572423 no 222 0.0379248950639199 268 5281571 An antioxidant.
SGTC_1294 1000-1494 117 µM 1.77266542737403 0.039146156468553 no 223 0.0381420815687085 294 712797 YDL207W GLE1
SGTC_1158 4092-0494 91.8 µM 1.77078804601006 0.0393046363991624 no 224 0.0382979772633478 297 1148199
SGTC_132 0417-1715 25.805 µM 1.76534364116756 0.0397671824250782 no 225 0.0387530145684729 286 6769098
SGTC_1673 st016611 27.3 µM 1.76425162013112 0.0398604891669875 no 226 0.0388448126733661 337 5226799
SGTC_1783 st039459 87.517 µM 1.76196893200885 0.0400561061705282 no 227 0.039037273383609 341 729761
SGTC_2010 4012422 159 µM 1.75986326082846 0.0402372445147273 no 228 0.039215496931871 306 952393
SGTC_915 methyl methanesulfonate (MMS) 110 mM 1.75725229019037 0.0404627741520834 no 229 0.0394374079893127 317 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks.
SGTC_1193 1488-0126 41.5 µM 1.75567802557089 0.0405992507454406 no 230 0.0395717004938528 332 1384710
SGTC_2027 5150920 200 µM 1.74887867834175 0.0411929994949066 no 231 0.0401559964534627 279 786715
SGTC_1618 st003135 44.5 µM 1.74706868668916 0.0413522368171262 no 232 0.0403127121419609 262 1270615
SGTC_190 3970-0790 3.722 µM 1.74363855240241 0.0416553776479575 no 233 0.0406110681798532 273 2832352
SGTC_2339 9000433 200 µM 1.7384796487821 0.0421146869202793 no 234 0.0410631665018331 285 2988954
SGTC_3047 9092122 49.47 µM 1.7360686535286 0.0423307444644911 no 235 0.0412758480838192 302 17173831
SGTC_1574 spiramycin 23.7 µM 1.73202521991968 0.042695102617809 no 236 0.0416345360938348 342 6419898 An antibiotic and protein synthesis inhibitor.
SGTC_583 1488-1091 88.9 µM 1.72489314482368 0.043343958646187 no 237 0.0422733656062974 378 4303273
SGTC_869 0564-0080 44.1 µM 1.72358519555103 0.043463811730423 no 238 0.0423913765069147 348 6843321
SGTC_1197 1601-0112 267 µM 1.72075221209326 0.0437243276461501 no 239 0.0426478987202809 346 7350313
SGTC_672 1441-0018 53.7 µM 1.71823732948733 0.043956645867638 no 240 0.0428766676040901 294 251141
SGTC_2524 avocatin b 10.57 µM 1.71754291608916 0.0440209690349067 no 241 0.042940010054487 276 6710748
SGTC_2896 9052656 71.43 µM 1.71434824284831 0.0443178684771241 no 242 0.0432323939844776 494 6469436
SGTC_2201 6605497 169.863 µM 1.7137143149629 0.0443769745160171 no 243 0.0432906032817698 269 670741
SGTC_2550 chrysin dimethyl ether 71.87 µM 1.71307159258155 0.044436965368982 no 244 0.0433496847121825 205 88881 An O-methylated flavonoid and antioxidant.
SGTC_1027 k015-0025 8.67 µM 1.70055978364779 0.0456178721758384 no 245 0.0445128406680953 336 3598955
SGTC_1548 st061468 90.8 µM 1.70002409453772 0.045668990202908 no 246 0.0445631967359104 292 390799
SGTC_282 k297-0036 65.7 µM 1.69613901248096 0.0460411027484564 no 247 0.04492977848656 270 5061378
SGTC_3342 9147791 14.508 µM 1.68665106638224 0.046960098348948 no 248 0.0458352332304787 320 1838168
SGTC_1511 0906-3109 28.5 µM 1.68593834216279 0.0470297221216808 no 249 0.0459038379374823 450 2882180
SGTC_1965 Pectolinarigenin 58.4 µM 1.68294831490347 0.0473227108626701 no 250 0.0461925486727635 302 5320438 An anti-inflammatory.
SGTC_1303 1160-0052 261 µM 1.67968714492986 0.0476439343596812 no 251 0.0465091011141506 330 3562476
SGTC_671 0560-0003 407 µM 1.67724420252381 0.0478857050771955 no 252 0.0467473693083528 318 3238678
SGTC_471 1-acyl-paf 4 µM 1.67689861050844 0.0479199864481916 no 253 0.0467811549584 344 16759367
SGTC_301 4119-0100 24.5 µM 1.67618791882643 0.0479905460130529 no 254 0.0468506949177198 395 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1
SGTC_3149 9097855 49.47 µM 1.67254108714404 0.0483539233453863 no 255 0.0472088364533356 310 25236625 YMR079W SEC14
SGTC_3159 9100096 49.47 µM 1.67101439804201 0.0485066976144305 no 256 0.0473594169668674 337 25236875
SGTC_2402 5553605 200 µM 1.66956602128883 0.0486519917909862 no 257 0.0475026289108502 353 6758546
SGTC_1776 st049249 45.9 µM 1.66603740342436 0.0490074221941725 no 258 0.0478529824122042 369 1822314
SGTC_1306 1185-0270 9.02 µM 1.66599428654274 0.0490117780630453 no 259 0.0478572762102835 363 1548076
SGTC_2860 9025725 38.96 µM 1.66378920239175 0.049234958658459 no 260 0.0480772812637179 302 40546248
SGTC_517 1365-0151 113 µM 1.6611030305269 0.0495079266471654 no 261 0.0483463779685325 333 768657
SGTC_1581 himbacine 57.9 µM 1.66066073628457 0.0495529880561741 no 262 0.0483908016428655 379 5281825 An alkaloid muscarinic receptor antagonist.
SGTC_77 0828-0286 12.516 µM 1.65841798291252 0.0497819861871405 no 263 0.0486165646855107 372 745345
SGTC_2664 lyso-paf C-16 73.48 µM 1.65141094304578 0.0505028886055126 no 264 0.0493273459246197 362 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_745 0469-0705 296 µM 1.64917232816335 0.0507349481305268 no 265 0.0495561676441289 398 3486736
SGTC_179 1273-0063 6.77 µM 1.64839759896863 0.0508154556892599 no 266 0.0496355542072605 290 3108139
SGTC_1167 k781-0610 148 µM 1.64470850704474 0.0512002115083618 no 267 0.0500149688209249 392 4525169
SGTC_2906 7926292 26.41 µM 1.64251395693332 0.0514301906166881 no 268 0.0502417680587162 360 2966319
SGTC_285 1486-1325 46 µM 1.63417014642651 0.0523120937038529 no 269 0.0511115645788143 374 22310230
SGTC_1242 0402-0103 60.1 µM 1.63130592157653 0.0526175830798168 no 270 0.051412892263625 327 432868
SGTC_501 nsc-95397 161 µM 1.62803392645922 0.0529682945842609 no 271 0.0517588461121026 317 262093
SGTC_2461 5755302 26.15 µM 1.62745533938001 0.0530305033832004 no 272 0.0518202132363458 387 2788904
SGTC_356 1634-0012 32.5 µM 1.62471407803344 0.0533260275155564 no 273 0.0521117481236283 391 735457
SGTC_937 3122-0005 46.7 µM 1.62165052943851 0.0536578389857432 no 274 0.052439098441219 377 759535
SGTC_969 1313-0238 134 µM 1.61867190036677 0.0539820188279816 no 275 0.0527589379442549 414 5212874
SGTC_2555 cholic acid 100 µM 1.61457248867341 0.0544307124084562 no 276 0.05320165359393 346 6708657 Influences liver metabolism.
SGTC_235 0330-0087 5 mM 1.60709468574375 0.0552567752469893 no 277 0.0540167994497832 397 46494818 YHR062C RPP1
SGTC_3195 9113082 49.47 µM 1.60271233990237 0.0557454696782999 no 278 0.0544990889348426 317 17018038
SGTC_3292 9120825 59.784 µM 1.60244580848461 0.0557753014284389 no 279 0.0545285309798152 361 24824900
SGTC_710 3448-4187 58 µM 1.59855180349027 0.056212579093375 no 280 0.0549601130578046 472 3946412
SGTC_431 k089-0097 107 µM 1.59838874964222 0.0562309480345851 no 281 0.0549782434264565 460 5499420
SGTC_3001 9076041 71.4286 µM 1.5979949365216 0.0562753328356747 no 282 0.0550220519927981 347 16004211
SGTC_3008 9078912 71.4286 µM 1.59389333881883 0.0567392478659168 no 283 0.05547996332443 340 16648731
SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM 1.59348339801361 0.056785779709253 no 284 0.0555258949064331 360 7104
SGTC_272 doxorubicin 8.13 µM 1.59290760584602 0.0568511878738757 no 285 0.0555904598961989 423 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_797 k781-0471 270 µM 1.59262395467176 0.0568834315547077 no 286 0.0556222881786622 375 23738129
SGTC_558 k064-0027 21.3 µM 1.58161638433985 0.0581458622862597 no 287 0.0568685856926849 377 5088526
SGTC_2910 7948405 25.97 µM 1.58148703735392 0.0581608265700412 no 288 0.056883360258369 336 2971328
SGTC_1057 3448-5381 134 µM 1.57602123299446 0.0587959408893803 no 289 0.0575104549725427 401 5497911
SGTC_3291 9121177 71.43 µM 1.57396005648126 0.0590368535162624 no 290 0.0577483420710382 318 17015612
SGTC_3004 9076122 71.4286 µM 1.57375521932988 0.0590608373525627 no 291 0.0577720251971733 394 44782551
SGTC_2908 7930301 100 µM 1.57290415143128 0.0591605684821592 no 292 0.0578705068508856 419 2223178
SGTC_3054 9094397 49.47 µM 1.56988440773094 0.0595154987238053 no 293 0.0582210028436265 414 2598354
SGTC_2578 7,8-dihydroxyflavone 64.44 µM 1.56895211184528 0.0596254140871792 no 294 0.058329548938563 383 1880 Intensifies effect of antibiotics on Staphylococcus aureus.
SGTC_1397 3532-0190 20.1 µM 1.56724733471655 0.0598268143863957 no 295 0.058528445110056 302 5322280
SGTC_2232 chlorophetanol 41.5365 µM 1.56704690958584 0.0598505273348823 no 296 0.0585518636305191 524 15907 An antifungal of unknown mechanism. YFR051C RET2
SGTC_2680 butyl paraben 22.24 µM 1.56680163975344 0.059879556022573 no 297 0.0585805320052777 321 7184 An antifungal and steroid mimetic.
SGTC_1017 4239-0030 168 µM 1.56280746082466 0.0603538371383006 no 298 0.0590489444040218 428 1149593
SGTC_2831 7999036 19.48 µM 1.56243664252305 0.0603980179704156 no 299 0.0590925802874561 425 2988270
SGTC_1320 1313-0481 95.3 µM 1.56099553883872 0.0605699573894292 no 300 0.0592624017328427 384 6813365 YLR208W SEC13
SGTC_2667 digitoxin 100 µM 1.55630339760645 0.0611324351426716 no 301 0.0598179819509055 278 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_3029 9088683 49.47 µM 1.55597318706192 0.0611721728903822 no 302 0.0598572342000476 370 25236615
SGTC_2285 7945142 200 µM 1.55247666348758 0.0615941862817056 no 303 0.0602741061574796 390 2970608
SGTC_2940 9060638 45.86 µM 1.54357416966073 0.0626789381335603 no 304 0.0613457632933691 410 4027022
SGTC_1668 st014914 51.6 µM 1.54139562721775 0.062946643774962 no 305 0.0616102638184875 350 2839556
SGTC_2194 5927483 104.545 µM 1.53764005300946 0.0634102299341418 no 306 0.0620683242641333 434 760979
SGTC_2187 6125751 200 µM 1.52701078722773 0.0647367108430321 no 307 0.0633791645034044 414 874498
SGTC_122 0236-0016 402.397 µM 1.5254778288057 0.0649297817592656 no 308 0.0635699797204288 481 6808838
SGTC_2814 7977482 42.97 µM 1.52404731830655 0.0651103526139657 no 309 0.0637484456618888 485 6456762
SGTC_2572 astragaloside iv 100 µM 1.52261311659347 0.0652917803759851 no 310 0.0639277631264796 411 45006101 An anti-inflammatory agent.
SGTC_1463 k081-0032 34.1 µM 1.52049712174012 0.0655601714287448 no 311 0.0641930407948357 315 977755
SGTC_2999 9069765 71.4286 µM 1.51810551234482 0.0658645502328538 no 312 0.0644939008844297 426 2097066
SGTC_883 0850-0245 24.6 µM 1.51596299730691 0.0661381559430449 no 313 0.0647643545846279 446 6823229 YPR165W RHO1
SGTC_1761 st044296 37 µM 1.51532508312179 0.066219789396678 no 314 0.0648450496018319 409 1826700
SGTC_695 3505-6186 243 µM 1.50774944413064 0.0671952151656966 no 315 0.0658093328442268 419 1819379
SGTC_2329 6138490 200 µM 1.50410397632258 0.0676685409006592 no 316 0.0662772983179688 394 720019
SGTC_1541 2',3',6-trimethoxyflavone 64 µM 1.50381446826649 0.0677062406074445 no 317 0.0663145723884764 433 688801
SGTC_3011 9081274 71.4286 µM 1.50362746530458 0.0677306007359429 no 318 0.0663386575886579 443 6625322
SGTC_2298 7976326 193.81 µM 1.5002573290986 0.0681707762889436 no 319 0.0667738790545753 346 2235818
SGTC_1013 4112-3890 241 µM 1.49895961392786 0.0683408592804166 no 320 0.0669420547445573 445 705171
SGTC_1676 st018489 23.4 µM 1.4956179664695 0.0687803341990544 no 321 0.0673766192528879 451 3696235
SGTC_2468 5987765 72.9 µM 1.48287255025817 0.0704765669752237 no 322 0.069054137863649 422 26772094
SGTC_2005 4024620 188 µM 1.48278844915505 0.0704878654717873 no 323 0.069065312962715 411 236743
SGTC_944 3370-0224 231 µM 1.47515920021683 0.0715186146993154 no 324 0.0700848737811861 434 4580514
SGTC_1093 fluphenazine 7.97 µM 1.47429502136309 0.0716360950456724 no 325 0.0702010875386055 482 6602611 An atypical antipsychotic.
SGTC_1440 4100-1550 40 µM 1.47355472868037 0.071736851439859 no 326 0.0703007590457449 365 742806
SGTC_2531 methyl deoxycholate 70.07 µM 1.47001276650094 0.0722204295976991 no 327 0.0707791481930978 420 16667744 Haematoxylin.
SGTC_1212 0520-0165 585 µM 1.46738051854568 0.0725814213238535 no 328 0.0711362855221005 453 5403258
SGTC_684 1140-0066 328 µM 1.4638267808028 0.0730709784216526 no 329 0.0716206415619509 479 6813534
SGTC_906 1165-0455 526 µM 1.45889576478186 0.0737544477244957 no 330 0.0722968994995112 424 3252859
SGTC_1952 st077036 64.1 µM 1.45786125421021 0.0738984554330314 no 331 0.0724393951241279 472 2937007
SGTC_1485 3909-9022 254 µM 1.45707570912204 0.0740079496735134 no 332 0.0725477413792745 450 714516
SGTC_2320 7373003 200 µM 1.45318956975065 0.0745514484914566 no 333 0.073085563656063 430 5415828
SGTC_1835 st008666 49.2 µM 1.44656687791156 0.0754846824032666 no 334 0.0740091342491208 377 690455
SGTC_2557 derrustone 83.84 µM 1.44419745540736 0.0758207222599995 no 335 0.0743417202423949 506 629853 An antioxidant.
SGTC_2839 9003951 25.97 µM 1.44380721002122 0.0758761773476036 no 336 0.0743966066559537 414 2990634
SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM 1.44184405654914 0.0761556162064153 no 337 0.0746731855496556 444 6312947
SGTC_2866 9034245 58.44 µM 1.4414364121806 0.0762137391457041 no 338 0.0747307147896473 390 6462273
SGTC_2514 salinomycin 42.74 µM 1.4405696353176 0.0763374385371132 no 339 0.0748531519865465 523 23682228 A polyether potassium ionophore.
SGTC_1246 0422-0085 105 µM 1.43942666074991 0.0765007881086723 no 340 0.0750148375697804 503 264295
SGTC_680 0417-1641 114 µM 1.43584322318991 0.0770146431306186 no 341 0.0755234787183934 422 2835990
SGTC_861 0443-0273 110 µM 1.43496761039194 0.0771406014958259 no 342 0.0756481637895149 450 6149169
SGTC_3226 9131256 49.47 µM 1.43477296498043 0.0771686228184253 no 343 0.0756759021025057 299 17178073
SGTC_2581 avocatin a 64 µM 1.43469578658631 0.0771797356281512 no 344 0.0756869027006864 497 6710728 A skin care supplement.
SGTC_2352 9027995 87.8 µM 1.43384121538496 0.077302865432076 no 345 0.0758087901724799 393 2997347
SGTC_2229 7354935 190 µM 1.43305549938855 0.0774162059415081 no 346 0.0759209886918549 382 318112
SGTC_191 3914-0123 66.505 µM 1.43220909278065 0.0775384423119584 no 347 0.0760419951259416 319 3144412
SGTC_1441 4106-0040 13 µM 1.43030854233938 0.0778134499919093 no 348 0.0763142420741704 443 2904180
SGTC_511 blebbistatin 171 µM 1.42896354421151 0.0780085167098717 no 349 0.0765073559099031 445 3476986 A myosin inhibitor.
SGTC_250 brefeldin a 552.239 µM 1.42887124460165 0.0780219166265015 no 350 0.0765206218376127 378 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.
SGTC_766 1391-0721 126 µM 1.4272657625251 0.0782552775314776 no 351 0.0767516526532551 459 1020919 YIL115C NUP159
SGTC_2928 9011484 9.79 µM 1.42060104071045 0.0792296741206342 no 352 0.0777163878884304 428 2994751
SGTC_3105 9121040 49.47 µM 1.41842640441056 0.079549590146527 no 353 0.0780331556124917 238 41448907
SGTC_589 1227-0070 34.1 µM 1.41299178588317 0.0803533628379573 no 354 0.0788290696528602 465 2841384
SGTC_2761 levamisole 97.89 µM 1.41016702953268 0.0807735568615991 no 355 0.0792451843667966 454 26879 An alkaline phosphatase inhibitor.
SGTC_3111 9122088 49.47 µM 1.41001691406527 0.0807959334908559 no 356 0.0792673443158752 350 16876704
SGTC_196 k015-0023 18.111 µM 1.40965700593834 0.0808496014605154 no 357 0.079320492829629 506 5211998
SGTC_1159 4092-0538 61.2 µM 1.40748669618988 0.0811737994461985 no 358 0.0796415597280446 522 717301
SGTC_2994 9053520 71.4286 µM 1.40213270870365 0.0819777645854689 no 359 0.080437810651206 477 4647384
SGTC_1844 rapamycin 4 nM 1.40192432374716 0.0820091769466012 no 360 0.0804689230560703 625 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2
SGTC_1264 0783-0040 158 µM 1.40103113455659 0.0821439208051663 no 361 0.0806023814808098 447 2855798
SGTC_2847 9005661 71.43 µM 1.40098585551505 0.0821507559050853 no 362 0.0806091514283065 320 2991449
SGTC_1252 0493-0875 34.8 µM 1.40006976196764 0.0822891368853787 no 363 0.0807462144612296 468 3960963
SGTC_1805 st050013 60.3 µM 1.39769967370573 0.0826479662913462 no 364 0.0811016361494239 427 4037144
SGTC_1989 st071868 50.2 µM 1.39714215988952 0.0827325442581513 no 365 0.0811854129524178 495 16414057
SGTC_354 2783-3500 4.88 µM 1.39664703955709 0.0828077113759684 no 366 0.0812598687064978 491 6740761
SGTC_1118 chelidonine 707.474 nM 1.3952858187536 0.0830146311030698 no 367 0.0814648333779869 520 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor.
SGTC_1271 0832-2808 169 µM 1.39299513859928 0.0833637158298423 no 368 0.081810630378455 493 3663794
SGTC_1134 3477-0009 42.5 µM 1.39280003937091 0.0833934985964561 no 369 0.0818401332592955 537 3973534
SGTC_2782 7736369 71.43 µM 1.39210449853572 0.0834997410864383 no 370 0.0819453781101244 517 2950836 YOL077C BRX1
SGTC_831 k061-1017 217 µM 1.39063372459631 0.0837247338128726 no 371 0.0821682621374764 652 1240153
SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM 1.3897513692989 0.0838599311569232 no 372 0.0823021949994943 522 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis.
SGTC_1354 1498-1681 81 µM 1.38537741525793 0.0845325443986909 no 373 0.0829685465780075 529 5754243
SGTC_3240 9133527 49.47 µM 1.38382183266233 0.0847727301726387 no 374 0.0832065080823019 479 17617455
SGTC_3071 9117417 49.47 µM 1.38216691686108 0.0850288146453383 no 375 0.0834602278197043 383 45595590 YGL055W OLE1
SGTC_853 0419-0306 21 µM 1.38102450141813 0.0852059319337744 no 376 0.0836357136453225 466 762713
SGTC_1024 4507-0395 26 µM 1.38026886594365 0.0853232356086011 no 377 0.0837519386420074 491 4201836
SGTC_3031 9088762 49.47 µM 1.37943914073885 0.0854521801663271 no 378 0.0838796991557288 499 205253
SGTC_175 3793-3120 23.7 µM 1.37633773362711 0.0859354509737501 no 379 0.084358547888118 458 5322297
SGTC_2946 9065502 71.43 µM 1.37534728102948 0.0860902164309502 no 380 0.084511902384135 329 16489101
SGTC_1894 3',6'-dihydroxyflavone 78.7 µM 1.37472462209445 0.0861876181351899 no 381 0.0846084173864045 479 688662
SGTC_3215 9129942 49.47 µM 1.37107712299117 0.0867598478695838 no 382 0.0851754578065646 440 17682944
SGTC_889 0919-1524 82.7 µM 1.36579610816918 0.0875933722680688 no 383 0.0860014841408819 470 3905452
SGTC_2727 riluzole 51.77 µM 1.36479816589008 0.0877515506674685 no 384 0.0861582477199406 445 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.
SGTC_1603 st002045 67.8 µM 1.3613749204791 0.088295769875893 no 385 0.0866976187784523 497 5887985
SGTC_199 4063-0024 41.6 µM 1.35902320211445 0.0886710953145681 no 386 0.0870696182666475 491 306215
SGTC_1824 st053723 68.6 µM 1.35872552217651 0.0887186885143491 no 387 0.0871167907422945 502 675225
SGTC_383 2324-0395 7.37 µM 1.35809808490654 0.0888190657654174 no 388 0.0872162814116552 523 3146421
SGTC_1144 3486-0183 12.5 µM 1.35344011651041 0.08956689183608 no 389 0.0879575343859276 556 6744069
SGTC_295 k015-0027 31 µM 1.34468573248928 0.0909850404851545 no 390 0.0893633720171448 500 3887424
SGTC_2093 5331342 194.4 µM 1.34230154599276 0.0913741324851969 no 391 0.0897491211840794 522 33839
SGTC_1077 5-fluorocytosine 377 nM 1.34022589349543 0.0917138758685483 no 392 0.0900859578921204 491 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_1728 st035614 33.7865 µM 1.33901694418815 0.0919121878315912 no 393 0.0902825784290136 573 15945546
SGTC_4 0960-0234 25.671 µM 1.3358186333592 0.0924383590812842 no 394 0.0908042805186967 473 6821112
SGTC_245 methotrexate 289.6 µM 1.33143151425892 0.0931637284015364 no 395 0.0915235328341353 569 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2
SGTC_3347 9188721 44.724 µM 1.32672481612633 0.093946605016355 no 396 0.0922998643944785 485 44118411 YKL104C | YBL026W GFA1 | LSM2
SGTC_2406 ethylparaben 405.7 µM 1.32382499162267 0.0944313508533728 no 397 0.0927805870213902 458 8434 A possible steroid mimic.
SGTC_422 cantharidin 155 µM 1.32176165212383 0.0947773879589241 no 398 0.0931237658161037 542 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_2933 9026794 32.47 µM 1.32004105595207 0.095066658271441 no 399 0.0934106554200021 555 17586027
SGTC_2126 5251174 33.877 µM 1.31979298987229 0.0951084172504798 no 400 0.0934520713734833 628 790722
SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM 1.31885926108603 0.0952657205325614 no 401 0.093608083977402 590 4174840
SGTC_2318 6029776 164 µM 1.31459124044784 0.0959871842059249 no 402 0.0943236578062848 555 818325
SGTC_1786 berberine 21.6 µM 1.31234433165086 0.0963686109226159 no 403 0.0947019903255101 548 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_2400 5203494 178.7 µM 1.31090357115791 0.0966137743558197 no 404 0.0949451721001354 499 6777674
SGTC_2540 epiandrosterone 100 µM 1.31037849287308 0.0967032368145045 no 405 0.0950339128222263 681 441302 A steroid.
SGTC_3249 9135183 49.47 µM 1.30814758389016 0.0970840159133544 no 406 0.0954116282819555 565 4902779
SGTC_472 calcifediol 10 µM 1.30651525651523 0.097363323454325 no 407 0.0956886971058919 458 5283731 A vitamin D metabolite.
SGTC_859 0439-0102 54.6 µM 1.2976101141452 0.0988974679044363 no 408 0.0972106724359829 604 610143
SGTC_1492 4158-0558 28.5 µM 1.29149570008753 0.0999610291905569 no 409 0.0982659225872394 530 3967268
SGTC_218 alverine citrate 93.75 µM 1.28942301006517 0.100323448609394 no 410 0.0986255330805367 525 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_1037 k284-1091 78.7 µM 1.2889002615862 0.100415004838169 no 411 0.098716381558493 493 3334711
SGTC_2146 5545642 200 µM 1.28196641860661 0.101635198004672 no 412 0.0999272133321418 562 825326
SGTC_1935 st074532 41.6 µM 1.28164737344455 0.101691601128243 no 413 0.0999831869055987 652 2829742
SGTC_375 3970-0961 9.27 µM 1.27983307217873 0.102012779824453 no 414 0.100301924918926 562 2898222
SGTC_2164 5685496 200 µM 1.27820739403106 0.102301193768737 no 415 0.100588154862937 597 759046
SGTC_704 1310-0270 142 µM 1.27646499406314 0.102610973457067 no 416 0.100895596848358 585 5718033
SGTC_2125 5246583 200 µM 1.27613413070703 0.102669874301786 no 417 0.10095405415296 637 835267
SGTC_1950 st077106 7.18 µM 1.27402723293089 0.103045524305162 no 418 0.101326882495592 579 13831864
SGTC_1702 st027038 51 µM 1.27263626729384 0.103294073461772 no 419 0.101573571421051 598 5521182
SGTC_2881 9058953 51.95 µM 1.2714327550962 0.103509477886554 no 420 0.101787368000061 584 17122249
SGTC_1636 st007707 68.9 µM 1.269743328329 0.10381240096801 no 421 0.102088036735913 627 403051
SGTC_1149 3909-7961 23.3 µM 1.26549399748979 0.104577169973607 no 422 0.102847149386418 562 735261
SGTC_562 3772-2733 112 µM 1.26537067176638 0.104599426176198 no 423 0.102869241727329 658 2876874 YIL048W NEO1
SGTC_801 0866-0028 10.1 µM 1.26452262665058 0.104752563113237 no 424 0.103021252335512 611 6849771
SGTC_233 rapamycin 362 pM 1.26330932305307 0.104971939327131 no 425 0.103239018505374 564 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C
SGTC_1108 betulinic acid 729.144 nM 1.26230579433556 0.105153637497564 no 426 0.103419386253485 579 64945 Apoptosis-inducing agent of unknown mechanism.
SGTC_947 3447-0010 211 µM 1.2602491255275 0.105526727410207 no 427 0.103789753112359 554 748350
SGTC_2843 9000894 45.46 µM 1.25932726159249 0.105694268457759 no 428 0.103956075163842 419 2242070
SGTC_444 curcumin 90.4 µM 1.25792978147488 0.105948615363543 no 429 0.104208576013712 602 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties.
SGTC_1051 3253-3903 78 µM 1.25777389416525 0.105977014868727 no 430 0.104236769732538 596 5509239
SGTC_51 1013-0126 23.419 µM 1.25578142964202 0.106340486064342 no 431 0.104597613151687 553 1627850
SGTC_1436 4092-1007 8.32 µM 1.25353108229063 0.106752082573786 no 432 0.105006247314905 548 2881121
SGTC_2208 7283366 200 µM 1.25300307871553 0.106848822595703 no 433 0.105102293132151 581 898663
SGTC_639 0833-0042 114 µM 1.25198423841589 0.107035671737079 no 434 0.105287803654989 619 5978911 YPR085C | YHR062C ASA1 | RPP1
SGTC_1545 lovastatin 49.4 µM 1.24999263681267 0.10740159979552 no 435 0.105651118552476 613 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12
SGTC_462 ag-879 158 µM 1.24830151563537 0.107713026141133 no 436 0.105960329688302 621 6809654 Ag-879 is a 5-Lipoxygenase inhibitor.
SGTC_567 1080-0542 68.4 µM 1.24810826493094 0.107748655363344 no 437 0.105995705987304 521 5950415
SGTC_812 4251-0442 148 µM 1.24540447044739 0.108248038793518 no 438 0.106491555433697 575 5723007
SGTC_2413 inermin 26.06 µM 1.24332992127951 0.108632330189863 no 439 0.106873141279297 608 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1
SGTC_2863 9028737 58.44 µM 1.24144172767596 0.108982953031915 no 440 0.107221306160737 534 6460917
SGTC_2796 7949634 45.45 µM 1.23673907627617 0.109859732776547 no 441 0.108091983277625 573 2971588
SGTC_1735 st034310 56.75 µM 1.23399406406744 0.110373857061143 no 442 0.108602558078802 595 871153
SGTC_679 0422-0091 41.4 µM 1.23340248074041 0.110484882662755 no 443 0.108712819963732 623 627384 YHR062C RPP1
SGTC_1407 3909-7909 12.3 µM 1.23327486829326 0.110508842866655 no 444 0.108736615481608 611 4411780
SGTC_1386 3228-0095 33.8 µM 1.23114474246558 0.11090934026814 no 445 0.109134366963758 573 870181
SGTC_26 0302-0163 425.158 µM 1.23086609468486 0.110961807270654 no 446 0.109186475190945 594 3100915
SGTC_598 3937-0236 20.2 µM 1.22958630032807 0.111203009983449 no 447 0.109426031365483 652 1379313
SGTC_1834 st055981 52.8 µM 1.22614162351527 0.111854092296729 no 448 0.110072692319222 619 471719 YDL150W RPC53
SGTC_2935 9038016 29.96 µM 1.22265762143188 0.112515376002044 no 449 0.11072951982613 627 6463195
SGTC_2628 lathosterol 100 µM 1.22067508338511 0.112892917538679 no 450 0.111104532699279 612 6710616
SGTC_2859 9028643 45.46 µM 1.21939938808826 0.113136330244146 no 451 0.111346321038336 556 17151580
SGTC_796 1234-0020 70.7 µM 1.21646209458826 0.113698212194088 no 452 0.111904471099651 601 46495034
SGTC_2642 cholecalciferol 100 µM 1.21279953801099 0.114401614291968 no 453 0.112603236052344 577 9821465 A vitamin D precursor, similar to steriods.
SGTC_3052 9092717 49.47 µM 1.21225843691958 0.114505796050646 no 454 0.112706734262717 574 25237534
SGTC_3090 9117696 49.47 µM 1.21175838827765 0.114602133735916 no 455 0.112802440613068 585 7923821
SGTC_319 1348-1596 45.5 µM 1.20605535898283 0.11570494219278 no 456 0.11389807294261 647 5380505
SGTC_805 3852-0218 479 µM 1.20490927404074 0.115927469965761 no 457 0.114119164012794 593 6615355
SGTC_2767 sibutramine 71.45 µM 1.2037240106592 0.116157924202874 no 458 0.114348134357808 622 64765 A serotonin-norepinephrine reuptake inhibitor.
SGTC_632 0781-2353 4.65 µM 1.20278004653202 0.116341694362688 no 459 0.114530724124763 642 6811515 YHR007C ERG11
SGTC_450 aminopyrene 156 nM 1.20270160460731 0.116356974649491 no 460 0.114545906378957 636 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1
SGTC_253 dyclonine 31.25 µM 1.2018576518771 0.11652146455939 no 461 0.114709342107251 664 3180 An oral anasthetic.
SGTC_2617 dihydrotanshinone i 20.83 µM 1.20156667166223 0.116578216034016 no 462 0.11476573035047 655 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12
SGTC_2263 7948595 193.29 µM 1.19738514531362 0.117395927712596 no 463 0.11557823543572 556 2971371
SGTC_1521 st012942 49.4 µM 1.1962969141292 0.117609399486245 no 464 0.115790356284452 677 24207259
SGTC_1365 1672-3266 55.4 µM 1.194450345911 0.117972258117927 no 465 0.116150926477586 669 6415873
SGTC_2381 9035592 200 µM 1.19363772197556 0.118132192925217 no 466 0.116309855760145 550 4749657
SGTC_1695 st026914 34.495 µM 1.18762521207074 0.119320297293529 no 467 0.117490550152483 626 3289191
SGTC_1190 1486-1332 13 µM 1.18404742276666 0.120031276844306 no 468 0.118197145516142 620 4150046
SGTC_527 4476-4215 268 µM 1.18241144735388 0.120357371313194 no 469 0.118521241607989 644 4418754
SGTC_1402 3909-7673 35.9 µM 1.18224216285288 0.120391149919297 no 470 0.118554813657722 622 5328014
SGTC_2014 4013930 200 µM 1.18005997529277 0.120827176066219 no 471 0.11898818100343 711 64556
SGTC_369 0957-0393 4.5 µM 1.17822865643356 0.12119395140443 no 472 0.119352730573492 574 6997992
SGTC_1787 fluconazole 80 µM 1.17460419508982 0.121922163061665 no 473 0.120076552087931 688 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C
SGTC_1499 4480-0877 67.3 µM 1.17318059685494 0.122209025462741 no 474 0.120361695636824 591 2861909
SGTC_1385 3091-4834 14.1 µM 1.17057253370798 0.122735792179697 no 475 0.120885321467682 585 4072814
SGTC_40 0327-0103 19.753 µM 1.1685383019695 0.123147762619138 no 476 0.121294849393152 634 409036
SGTC_1429 4049-0205 9.46 µM 1.16754526405333 0.123349223241047 no 477 0.121495120007778 702 22774478
SGTC_2045 5106652 78.05 µM 1.16691997118642 0.123476196717631 no 478 0.12162134495466 632 673349
SGTC_2747 doxorubicin 7.63 µM 1.16655744133793 0.123549854815404 no 479 0.121694569352994 449 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_2681 menadione 3.18 µM 1.16270668244087 0.124334144147735 no 480 0.12247426472225 644 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_1750 st081859 2.357 µM 1.16209583716396 0.124458875107594 no 481 0.122598269094577 814 5291695
SGTC_2711 st079103 59.1 µM 1.16149955061984 0.12458071762384 no 482 0.122719402911738 626 54693780
SGTC_1737 st035557 69.7 µM 1.16041006007512 0.124803554539372 no 483 0.12294094640538 543 5716916
SGTC_2247 cerulenin 830 nM 1.16028731708351 0.12482867699397 no 484 0.122965923260421 651 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12
SGTC_1920 st075728 45.7 µM 1.15643935416893 0.125618052140883 no 485 0.123750746125836 649 3400306
SGTC_2661 dactinomycin 12.96 µM 1.15569363439502 0.125771431890614 no 486 0.123903246415644 700 45006140 An Actinomycin D Classic transcription inhibitor.
SGTC_119 0121-0043 24.815 µM 1.1547280157175 0.125970234507373 no 487 0.124100911571513 826 1092378
SGTC_152 4469-0003 551.229 µM 1.15263409758002 0.126402085108195 no 488 0.124530300814489 650 697280
SGTC_2543 pimpinellin 60.67 µM 1.14847704587785 0.127262491420027 no 489 0.125385841812171 637 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo.
SGTC_1069 diphenylcyclopropenone 8.49 µM 1.14843046252281 0.127272156043753 no 490 0.125395452076645 748 65057 A dermal irritant. YDR527W RBA50
SGTC_126 0417-1624 672.48 µM 1.1476687830642 0.127430253701789 no 491 0.125552661420182 810 41912 YDL195W SEC31
SGTC_2083 5306046 65.942 µM 1.14761291443062 0.127441855423886 no 492 0.125564198022763 664 539837
SGTC_1253 0550-0034 176 µM 1.14564391725752 0.12785120805049 no 493 0.125971258919858 620 5969915
SGTC_1122 capsaicin 818.572 nM 1.14382750096426 0.128229648714667 no 494 0.126347591154827 674 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_1621 st003705 32.4 µM 1.14367127176841 0.128262234528737 no 495 0.126379995880648 726 24207032
SGTC_2743 auranofin 4.32 µM 1.14342723489653 0.128313146508051 no 496 0.126430625073731 631 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold.
SGTC_2772 vinpocetine 57.06 µM 1.14143819789274 0.12872863088411 no 497 0.126843808301047 649 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor.
SGTC_2030 5175110 200 µM 1.1405276201394 0.128919150059123 no 498 0.127033276229976 678 2831986
SGTC_731 3966-0296 387 µM 1.13959957902055 0.129113524209931 no 499 0.127226580410462 667 660956
SGTC_1863 st057641 20.1 µM 1.13809791616056 0.129428471127153 no 500 0.127539799090908 731 3921635
SGTC_1830 st055982 50.3 µM 1.13553542433793 0.12996713638495 no 501 0.128075524057942 682 455313 An antimicrobial agent.
SGTC_1162 k048-0130 20.1 µM 1.1335850276406 0.130378170953226 no 502 0.128484328180969 670 6797406
SGTC_2226 7298446 200 µM 1.13335652869195 0.130426384533284 no 503 0.128532280879328 625 3283010
SGTC_740 k014-0057 261 µM 1.13067951237533 0.130992157127621 no 504 0.129095003761207 749 4012779
SGTC_2934 9036370 36.88 µM 1.12848265120241 0.131457716635007 no 505 0.12955806980779 711 6462800
SGTC_1165 k072-0275 30.3 µM 1.12447431436937 0.132310105263979 no 506 0.130405930581334 669 6153523 YGL055W OLE1
SGTC_1529 apigenin 74 µM 1.12400091994551 0.132411025414635 no 507 0.130506317838387 709 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_2644 guaiazulene 100 µM 1.12120129341567 0.133008945659922 no 508 0.131101094653477 681 3515 A coloring agent.
SGTC_2377 9073351 62.6 µM 1.11771332726588 0.133756472341084 no 509 0.131844724461038 673 7337946 YHR072W ERG7
SGTC_2621 lithochol-11-enic acid 100 µM 1.11697693433558 0.133914661588942 no 510 0.132002093757609 742 6708711
SGTC_903 1134-0042 114 µM 1.11662492282396 0.133990324821827 no 511 0.132077365378982 672 701009
SGTC_269 exalamide 29 µM 1.11632288806464 0.134055269196501 no 512 0.132141973917987 663 3316 A derivative of salicylamide.
SGTC_1275 0867-0008 21.1 µM 1.1153330942149 0.134268249043743 no 513 0.132353854349391 700 3422836
SGTC_72 0744-0168 198.391 µM 1.11451068305966 0.134445388832291 no 514 0.132530081981501 668 677577
SGTC_1748 st037455 53.6035 µM 1.11401930966153 0.134551302675222 no 515 0.132635451411063 698 580690
SGTC_1862 st057513 3.81 µM 1.11215290171247 0.13495412232798 no 516 0.133036207162021 676 5393163
SGTC_588 3970-1144 52.9 µM 1.11189331670449 0.135010213018732 no 517 0.133092011298799 714 1888707
SGTC_1869 3',7'-dimethoxyflavone 40.3 µM 1.107803253969 0.135896097787685 no 518 0.133973397245315 716 688664
SGTC_2192 5915882 198.485 µM 1.10747504224511 0.135967358732369 no 519 0.134044298499749 643 2876149
SGTC_3099 9120367 49.47 µM 1.1052837903492 0.136443776310941 no 520 0.134518319728307 693 24824940
SGTC_2749 bexarotene 57.39 µM 1.10400914049454 0.136721432810474 no 521 0.13479458633645 676 82146 An retinoic acid receptor inhibitor.
SGTC_3250 9135583 49.47 µM 1.10398910282296 0.136725800690741 no 522 0.134798932391364 673 7699353
SGTC_2473 5854593 8.94 µM 1.10242337360893 0.137067398706007 no 523 0.135138827284796 673 2872951
SGTC_451 chloral hydrate 100 µM 1.09852303514291 0.13792087657308 no 524 0.135988082355907 763 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1
SGTC_2561 acetosyringone 100 µM 1.09689836188797 0.138277457289358 no 525 0.136342912462228 817 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent.
SGTC_1087 pterostilbene 9.05 µM 1.09197662037093 0.13936150655848 no 526 0.13742168881293 744 5281727 Similar to reservatol, lowers cholesterol.
SGTC_1524 corynanthine 62.1 µM 1.09166295326128 0.139430789459697 no 527 0.137490637220416 683 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist.
SGTC_1223 0764-0573 147 µM 1.09128463200235 0.139514384359138 no 528 0.137573828927962 741 1609797
SGTC_2593 nobiletin 86.24 µM 1.0908119556076 0.139618876118422 no 529 0.137677817320047 647 72344 An anti-infammatory.
SGTC_3202 9113761 49.47 µM 1.08980713812701 0.139841181916392 no 530 0.137899054472323 773 4798415
SGTC_1809 st050081 57.6 µM 1.08945336819262 0.139919507203247 no 531 0.137977003975547 716 5036894
SGTC_188 3229-0966 278.469 µM 1.08559203425797 0.140776352029774 no 532 0.138829762782664 837 5722370
SGTC_1148 3909-7663 27.7 µM 1.08507435924561 0.140891496186862 no 533 0.138944361321136 741 4084526
SGTC_2348 9022543 33.42 µM 1.08138982037 0.14171287726401 no 534 0.139761873946035 736 3162678 YDL140C RPO21
SGTC_1472 k841-0093 193 µM 1.07846147111944 0.142367992556009 no 535 0.14041393354914 765 X1472
SGTC_1115 galangin 695.678 nM 1.07751257553425 0.142580713425855 no 536 0.140625667857889 780 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_316 k060-0003 58.6 µM 1.07712044481678 0.142668682971131 no 537 0.140713230222982 714 6152314
SGTC_1562 morin hydrate 59.1 µM 1.07610190744832 0.142897350313106 no 538 0.140940841349212 699 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase.
SGTC_2778 tioconazole 65.09 nM 1.07580408046894 0.142964260914952 no 539 0.141007443492369 726 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_756 0508-1999 28.3 µM 1.07388332566287 0.14339629131737 no 540 0.141437488775859 709 6753853
SGTC_2488 5268135 45.7 µM 1.0738509953308 0.143403570831014 no 541 0.141444734938157 803 1270356 YLR208W SEC13
SGTC_843 0310-0051 143 µM 1.07219694847382 0.143776329784384 no 542 0.141815790371176 731 2065037
SGTC_2237 6667747 47.222 µM 1.06986221438008 0.144303601395436 no 543 0.14234066666457 699 729940 YDL015C TSC13
SGTC_2748 diazoxide 86.69 µM 1.06853181975224 0.144604637254428 no 544 0.142640342468442 670 3019 A potassium channel activatior.
SGTC_305 1682-2595 20.8 µM 1.06844432796128 0.144624449328 no 545 0.142660065223657 750 226033
SGTC_3252 9135871 49.47 µM 1.06511621230071 0.145379442094851 no 546 0.143411671796953 732 17682838
SGTC_3068 9116768 49.47 µM 1.06189215042649 0.146113353829637 no 547 0.144142324498855 678 41904888
SGTC_519 k048-0011 62.8 µM 1.06116297470335 0.146279684780808 no 548 0.14430792128532 731 6836379
SGTC_1939 st074455 53.6 µM 1.05937583989698 0.146687882384719 no 549 0.144714324101111 760 1644229
SGTC_2941 9056145 11.23 µM 1.05920419402373 0.146727128031924 no 550 0.144753397710009 653 2119517
SGTC_3329 9141233 27.5565 µM 1.05914922016425 0.146739698915782 no 551 0.144765913507034 725 4909101 YNL103W MET4
SGTC_1098 clofazimine 15.1 µM 1.05775868906921 0.147057912258332 no 552 0.145082735514451 782 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2
SGTC_607 4491-0986 66.8 µM 1.05551983770142 0.147571229356794 no 553 0.145593820789863 767 698981 YDR232W HEM1
SGTC_912 3474-0017 2.18 µM 1.05365065082119 0.148000709187707 no 554 0.146021445196745 765 3360550
SGTC_580 1123-0028 41 µM 1.05322956603727 0.148097576456856 no 555 0.146117895476221 824 1677248 YPR107C YTH1
SGTC_979 1426-2828 121 µM 1.04657773175293 0.149633407674622 no 556 0.14764718837096 807 747872
SGTC_2370 9071495 200 µM 1.04594521549827 0.149779999660824 no 557 0.147793163440727 711 21791103
SGTC_3016 9080866 49.47 µM 1.04519373700052 0.149954286818211 no 558 0.147966718744183 774 17066299
SGTC_257 daunorubicin 18.5 µM 1.04477510460151 0.150051437049809 no 559 0.148063461790159 755 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_1973 st070275 50.2 µM 1.04471838363621 0.15006460326906 no 560 0.148076572867717 735 17118334
SGTC_2926 9010726 65.15 µM 1.04262201904289 0.150551757208641 no 561 0.148561693562919 735 2994293
SGTC_452 diindolylmethane 8 µM 1.04148367978484 0.150816725681624 no 562 0.148825561856049 694 3071 Inhibits expression of several cancer promoting factors.
SGTC_591 4299-0174 154 µM 1.04011016663883 0.151136848061661 no 563 0.149144360416798 761 5509088
SGTC_10 0279-0212 42.575 µM 1.03698441849987 0.151867044803597 no 564 0.14987155943832 860 39851 YBR002C RER2
SGTC_629 3448-6466 76.7 µM 1.0330467373773 0.152790245637882 no 565 0.1507910135812 779 573744
SGTC_1866 st057638 64 µM 1.03190533441158 0.153058545255493 no 566 0.151058233382199 762 688802
SGTC_3041 9091929 49.47 µM 1.03182219857804 0.153078099463483 no 567 0.151077709049766 790 25236887
SGTC_1445 4239-0156 97.7 µM 1.03059527444933 0.153366874298578 no 568 0.151365326514461 850 4008346
SGTC_1781 st038725 66.3 µM 1.0303089557624 0.153434315560167 no 569 0.151432498156612 832 4270275 YIL048W NEO1
SGTC_1559 coumarin 343 70.1 µM 1.03020571907776 0.153458637380438 no 570 0.151456722804858 730 108770 A hepatotoxic, DNA x-linker.
SGTC_2252 omeprazole 400 µM 1.02789248127229 0.154004289224822 no 571 0.152000203357472 693 4594 A proton pump inhibitor.
SGTC_1721 st082152 9.2685 µM 1.02566736826504 0.15453036382685 no 572 0.15252420035486 725 5296051
SGTC_114 0364-0001 490.298 µM 1.02539645276751 0.154594496317279 no 573 0.152588080626278 771 4003655
SGTC_1214 0358-0031 63.7 µM 1.02507795283576 0.154669915729298 no 574 0.152663203723678 751 4301366
SGTC_2200 6600604 21.907 µM 1.02474305178819 0.154749245073983 no 575 0.152742221734055 794 2904777
SGTC_1916 st067606 49.2 µM 1.02430576644979 0.15485286705216 no 576 0.152845437567388 818 19590279
SGTC_1221 2958-7315 257 µM 1.02383110375427 0.154965398078542 no 577 0.1529575282068 752 4562705
SGTC_1423 4048-0112 5.59 µM 1.02037561454907 0.155786238166612 no 578 0.153775177224016 801 X1423
SGTC_433 pimozide 108 µM 1.01777903006127 0.156404931402248 no 579 0.154391489874995 639 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic
SGTC_189 3970-0742 2.116 µM 1.01774829520402 0.156412264333422 no 580 0.154398794717289 781 2891807
SGTC_2692 st077426 47.7 µM 1.01751942740664 0.156466876288615 no 581 0.154453197573799 802 25238571
SGTC_2041 5107442 45.335 µM 1.01591464610705 0.156850158493213 no 582 0.154835016876967 790 793005
SGTC_194 1486-1323 56.904 µM 1.01514271601247 0.157034744339159 no 583 0.15501890107692 767 5178754
SGTC_2458 5808907 16.39 µM 1.01468464794386 0.157144346239532 no 584 0.155128087242955 854 2731747
SGTC_619 1652-1634 108 µM 1.01088072710935 0.15805645298936 no 585 0.156036759711454 728 5400454
SGTC_60 0986-0278 202 µM 1.0095710032443 0.158371302162426 no 586 0.156350433928779 645 3110598
SGTC_2964 9083345 53.42 µM 1.00849411557332 0.158630487044605 no 587 0.156608655621055 725 17741579
SGTC_211 3455-0679 143.504 µM 1.00460414059718 0.159569040249694 no 588 0.157543751347412 816 748649
SGTC_1393 3470-5649 58.2 µM 1.00246249906262 0.160087312691093 no 589 0.158060134891742 682 4108395
SGTC_3260 9137109 49.47 µM 1.0022131691619 0.160147721412907 no 590 0.158120324385933 679 17478346
SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM 1.00204263811981 0.160189046988892 no 591 0.15816150010108 768 5711223 A potent inhibitor of glutathione S-transferases.
SGTC_1680 diphenhydramine 100 µM 0.999103045799599 0.160902507664421 no 592 0.158872387925146 774 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1
SGTC_2118 5526350 200 µM 0.999071618177187 0.160910146569445 no 593 0.158879999430152 828 743594
SGTC_2269 7935389 174.42 µM 0.99055721900396 0.162988404778756 no 594 0.160950918124401 766 97605
SGTC_1235 benzylparaben 21.5 µM 0.990131167907703 0.163092854931294 no 595 0.161055005421188 770 7180
SGTC_2641 levomentholum 100 µM 0.989774221808964 0.163180396874972 no 596 0.161142243688862 774 16666
SGTC_1305 1181-0477 144 µM 0.988505876333707 0.163491708822443 no 597 0.161452478976423 809 6252086
SGTC_1127 asiatic acid 681.4 nM 0.984638537665123 0.164443315960332 no 598 0.162400826439453 775 470603 A kinase inhibitor which arrests cells at G2/M.
SGTC_2144 5628481 200 µM 0.984360147857355 0.164511955513475 no 599 0.162469232697099 792 2818399
SGTC_167 3672-0051 66.205 µM 0.979094815795774 0.165813667359059 no 600 0.163766566469251 753 3237971
SGTC_1780 st038448 24.544 µM 0.975227436389567 0.166774002530675 no 601 0.164723727751368 822 728868 YDL195W SEC31
SGTC_1286 0929-0070 131 µM 0.973866930991081 0.167112690392517 no 602 0.165061307536421 860 1420408
SGTC_2250 alverine citrate 130 µM 0.973776511601598 0.167135215342874 no 603 0.165083759000433 873 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1
SGTC_1982 st072467 71.9 µM 0.972211215493109 0.167525466463566 no 604 0.16547274106027 872 3163533
SGTC_827 3253-0474 693 µM 0.969816036218323 0.168123754939608 no 605 0.166069099015711 880 5402065
SGTC_1484 3473-2379 286 µM 0.968039485890258 0.168568403892906 no 606 0.166512324972569 986 671917
SGTC_2975 9084847 53.72 µM 0.965820786798216 0.169124777944763 no 607 0.167066932562054 841 27211724
SGTC_728 3030-5151 22.5 µM 0.963866079576598 0.169615927783652 no 608 0.167556535990127 804 3125388
SGTC_1697 st025554 27.742 µM 0.963624262351658 0.169676751565339 no 609 0.167617169109088 808 1269519
SGTC_2610 ononetin 44.17 µM 0.960444124973191 0.170477946384568 no 610 0.168415869756204 838 259632
SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM 0.960325085325691 0.170507983861799 no 611 0.168445814349435 866 688798
SGTC_2819 7996655 46.38 µM 0.960302805947779 0.170513606031691 no 612 0.168451419139063 737 6456960
SGTC_2879 9041815 71.43 µM 0.959858117582092 0.170625847348903 no 613 0.168563313805959 762 4942971
SGTC_2499 avocadenofuran 51.48 µM 0.958996925824659 0.170843350435159 no 614 0.168780146936504 795 6857792 A insecticide and lysyl oxidase inhibitor.
SGTC_943 3253-1379 105 µM 0.956686851637573 0.1714276599125 no 615 0.169362668279533 839 668464
SGTC_1576 erythromycin ethylsuccinate 23.2 µM 0.954787263303573 0.171909097053963 no 616 0.169842644838695 878 3256 An antibiotic and ribosome inhibitor.
SGTC_41 0478-0632 82.643 µM 0.954528834704437 0.171974660593178 no 617 0.169908010359514 925 3750424
SGTC_1075 aripiprazole 15.2 µM 0.953278116474549 0.172292194344145 no 618 0.170224588085051 897 60795 An atypical antipschotic. YIL048W NEO1
SGTC_2142 5622915 118.518 µM 0.948805757417138 0.173430699777596 no 619 0.171359706558094 812 5322196
SGTC_297 0986-0032 24 µM 0.947004363645181 0.173890621101976 no 620 0.171818277686817 830 2847425
SGTC_1682 st012968 530 nM 0.946289611738558 0.174073322110514 no 621 0.172000445206885 762 24207270
SGTC_2574 2',4'-dihydroxychalcone 14.64 µM 0.945115262208589 0.174373767816108 no 622 0.172300017148025 917 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_1961 st076550 68.7 µM 0.944823143773162 0.174448554563058 no 623 0.172374587081536 808 1579337
SGTC_251 melphalan 456.522 µM 0.944152207286779 0.174620401596424 no 624 0.172545936946026 948 460612 A DNA alkylator.
SGTC_2262 9014885 67.46 µM 0.943203232345382 0.174863646119058 no 625 0.172788480193903 811 6457424
SGTC_2805 7950783 58.44 µM 0.940077056329957 0.1756664784579 no 626 0.173589018317676 897 1178958 YDL195W SEC31
SGTC_1661 st013063 9.66 µM 0.939138743206358 0.175907901343286 no 627 0.173829757393395 918 721395
SGTC_1907 st060210 83.7 µM 0.938576196723409 0.176052742207801 no 628 0.173974189357177 930 688793
SGTC_2397 5161689 200 µM 0.938396311699717 0.176099073778919 no 629 0.174020390342791 880 2259942
SGTC_2240 6690706 185.951 µM 0.93606428308202 0.176700414565803 no 630 0.174620045614652 747 805876
SGTC_2505 galangin 7.89 µM 0.935521006970235 0.176840690890638 no 631 0.174759931251885 791 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_33 0986-0033 35.816 µM 0.935505190569556 0.176844775810263 no 632 0.174764004808615 832 2848082
SGTC_88 0180-0332 8.668 µM 0.933577666638853 0.177343046068924 no 633 0.175260895033925 916 3101745
SGTC_1814 st052110 31.539 µM 0.93325414305538 0.177426764603701 no 634 0.175344382862262 866 674163
SGTC_1744 st037937 38.9 µM 0.931809640039653 0.177800864473244 no 635 0.175717455895005 855 1016152
SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM 0.931637960165531 0.177845359480487 no 636 0.175761829215207 935 16623 A steroid.
SGTC_287 k060-0039 29.6 µM 0.931386614495777 0.177910514479703 no 637 0.175826806195495 892 5861974
SGTC_3059 1327-0034 3 µM 0.930455300582472 0.178152065232905 no 638 0.176067698736585 852 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_2973 9094665 17.96 µM 0.930125132649854 0.17823774903495 no 639 0.176153149721384 923 25237061 YIL048W NEO1
SGTC_3076 9116187 49.47 µM 0.929940256715697 0.178285738605985 no 640 0.176201009049026 844 27241210
SGTC_274 sirtinol 40.1 µM 0.927338624432302 0.178961926253919 no 641 0.176875373134358 868 6836442 NAD-dependent acetyltransferase inhibitor.
SGTC_1443 4112-3303 14 µM 0.925710898649795 0.179385806454916 no 642 0.177298121228025 879 704433
SGTC_3194 9111903 49.47 µM 0.923579582652388 0.179941781372044 no 643 0.17785262407212 846 17087251
SGTC_1452 4194-0072 190 µM 0.921958468644445 0.1803653887948 no 644 0.178275119643291 959 1343545
SGTC_1054 3429-0080 167 µM 0.920372450437721 0.180780430458321 no 645 0.178689080090358 925 1162877
SGTC_150 3970-0969 77.2 µM 0.918104038312907 0.18137508590702 no 646 0.179282200434616 919 6615640
SGTC_65 0798-0905 34.986 µM 0.917126530265285 0.181631713003427 no 647 0.179538170135157 956 3602145
SGTC_2178 5812956 200 µM 0.917012448051987 0.181661678028954 no 648 0.179568058599574 899 5403383
SGTC_3297 9117502 71.43 µM 0.916885534468025 0.181695016998356 no 649 0.17960131243641 905 7453720
SGTC_1348 1493-0373 93.8 µM 0.916567900791456 0.181778473067794 no 650 0.179684555623354 879 3010129
SGTC_2890 9046729 58.44 µM 0.915097406590392 0.182165147740366 no 651 0.180070248170446 828 903329
SGTC_2738 aclarubicin 5.55 µM 0.914797253135904 0.182244137905897 no 652 0.180149038559004 813 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31
SGTC_2967 9089538 49.85 µM 0.914783109842425 0.182247860467011 no 653 0.180152751712377 907 728216
SGTC_966 1300-0360 30.2 µM 0.912240809018275 0.182917774216487 no 654 0.180820982870309 856 70588
SGTC_2265 7929201 200 µM 0.911274487457743 0.183172809151953 no 655 0.181075382687503 952 1265108
SGTC_2624 nerol 100 µM 0.910965745651675 0.183254340088654 no 656 0.181156711217809 882 637566 A natural product oil.
SGTC_1762 st045503 25.4615 µM 0.909783571421145 0.183566731716631 no 657 0.181468330139868 910 4645554
SGTC_595 3909-8003 73.7 µM 0.90838479867624 0.183936788264225 no 658 0.181837477142294 904 699517
SGTC_407 eburnamonine 100 µM 0.907830179369333 0.184083645776417 no 659 0.181983975439266 843 3195
SGTC_2050 5263056 171 µM 0.904152699580686 0.185059250382598 no 660 0.182957218715736 950 763468 YGL055W OLE1
SGTC_1936 st074407 74.3 µM 0.904091067300653 0.185075628230581 no 661 0.182973557293353 938 809813
SGTC_1136 pergolide 1.05886 µM 0.903471448627473 0.185240332565152 no 662 0.183137867382219 917 47811 A dopamine receptor agonist.
SGTC_1694 st024011 44.9 µM 0.902961798278094 0.185375873801515 no 663 0.183273085103759 961 2787533
SGTC_625 k213-0058 121 µM 0.901899294406415 0.185658644052471 no 664 0.183555183111942 1040 3655420
SGTC_1784 st039334 36.3 µM 0.901183748317352 0.185849227156794 no 665 0.183745315178441 899 3496984
SGTC_1567 st069303 68.4 µM 0.901157116966924 0.185856322661484 no 666 0.183752393922518 905 5581319
SGTC_337 1315-0038 354 µM 0.900507782437837 0.186029379624153 no 667 0.183925042804694 887 1626437
SGTC_81 0411-0046 9.971 µM 0.899586812062688 0.186275002695798 no 668 0.184170089003964 843 12925265
SGTC_659 k018-0002 107 µM 0.899128173143186 0.186397396749902 no 669 0.184292196619209 931 6797879 YHR007C ERG11
SGTC_1967 st070177 51.4 µM 0.899006084532217 0.186429986155548 no 670 0.18432470986978 882 5729214
SGTC_370 0180-0345 38.7 µM 0.898429798382129 0.186583863242466 no 671 0.184478228022787 837 3989527
SGTC_3129 9127257 49.47 µM 0.897427142669175 0.186851774813305 no 672 0.184745517207569 770 837894
SGTC_6 0844-0013 19.835 µM 0.897298811782701 0.186886082254629 no 673 0.184779745182468 1101 1584900
SGTC_262 fenpropimorph 62.5 µM 0.897242536093626 0.186901127990865 no 674 0.184794756084918 858 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_2322 7413319 38.22 µM 0.897147261643503 0.186926602052994 no 675 0.184820171192877 943 1840400
SGTC_1570 verbenone 133 µM 0.897047629560136 0.186953243537753 no 676 0.18484675105293 944 29025 A natural terpanoid with antifungal properties.
SGTC_905 2-aminofluorene 215 µM 0.895738282785341 0.187303579377784 no 677 0.185196279493525 974 1539 An established DNA mutagen. YPR165W RHO1
SGTC_141 0443-0274 32.331 µM 0.891949903796069 0.18831950239045 no 678 0.186209892250044 1035 1627241
SGTC_718 1130-0073 349 µM 0.889431871150292 0.188996635761164 no 679 0.186885511355087 931 6740020
SGTC_3024 9090631 49.47 µM 0.888256930590232 0.189313105866757 no 680 0.187201280726036 891 25236383
SGTC_2508 celastrol 40.54 µM 0.887819392259823 0.189431040075912 no 681 0.187318954938095 874 122724 Celastrol is a natural product and antioxidant.
SGTC_725 1497-0963 19 µM 0.886677555846617 0.189739023894736 no 682 0.187626262679947 960 3549977
SGTC_1987 st072290 61.9 µM 0.885790264323947 0.189978562653654 no 683 0.18786527850845 961 54697379
SGTC_2129 girgensonine 121.053 µM 0.881112465127131 0.191244481343936 no 684 0.189128475562685 970 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_123 0083-0120 66.675 µM 0.880101978652943 0.191518619571317 no 685 0.18940203367318 908 16001701
SGTC_2283 7944793 200 µM 0.879284896844964 0.191740464348614 no 686 0.189623411399253 957 2970533
SGTC_727 3032-0951 202 µM 0.878111936689058 0.192059208129266 no 687 0.189941487886664 894 3652836
SGTC_1669 st015249 58.4 µM 0.877688948988018 0.192174231600577 no 688 0.190056271642523 1039 722793
SGTC_3317 9138495 8.753 µM 0.876806995134346 0.192414197704883 no 689 0.190295739497738 928 17020139
SGTC_62 0180-0423 3.232 µM 0.87598252849055 0.192638688033886 no 690 0.190519765977001 920 30102 YGL099W LSG1
SGTC_2418 pentamidine 31.67 µM 0.875724012119709 0.192709111248934 no 691 0.19059004413213 896 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_2052 5265182 7.135 µM 0.874426038258944 0.193062933897771 no 692 0.190943141221375 945 1239884
SGTC_1589 2',5'-dimethoxyflavone 47.2 µM 0.874013347561266 0.193175514838667 no 693 0.191055492437807 950 688667
SGTC_2965 9082772 38.63 µM 0.872938670355716 0.193468871963071 no 694 0.191348253534812 980 16459634
SGTC_2498 4'-Methoxychalcone 54.63 µM 0.872900729556709 0.193479233714983 no 695 0.19135859430228 956 641818 YHR062C RPP1
SGTC_537 1334-0398 209 µM 0.871605825887125 0.193833078906186 no 696 0.19171172567373 978 5846986
SGTC_596 1155-0152 116 µM 0.8672530389899 0.195025409455218 no 697 0.19290169057397 968 280313
SGTC_2608 thymoquinone 42.66 µM 0.865019124856723 0.195639058612602 no 698 0.193514145960336 908 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC).
SGTC_2038 4100038 30.985 µM 0.864380046209932 0.195814826918015 no 699 0.193689575293296 924 3596803
SGTC_1171 0368-0077 21.4 µM 0.863756136293887 0.195986515727038 no 700 0.193860934267788 904 3239779
SGTC_3319 9138450 16.7555 µM 0.863125805363279 0.196160064189393 no 701 0.194034150597776 902 2029690
SGTC_2477 5967686 25.23 µM 0.857470306882743 0.197721353197211 no 702 0.195592509064123 953 776118
SGTC_493 zm226600 134 µM 0.857199561796512 0.197796284501525 no 703 0.195667302311721 964 5240098 A potassium channel opener. YCR052W RSC6
SGTC_1689 st020265 53.493 µM 0.850808405352541 0.199570077377319 no 704 0.197437895868699 973 5758320 YPR016C TIF6
SGTC_2391 6285546 200 µM 0.850051220033308 0.19978085798243 no 705 0.197648305037516 998 846083
SGTC_2274 7947094 46.08 µM 0.849989433771725 0.199798063570504 no 706 0.197665480387647 1044 2971028
SGTC_2594 a-mangostin 100 µM 0.849205021410787 0.200016575950675 no 707 0.197883609814495 977 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis.
SGTC_1719 st032227 49.2 µM 0.848556138379092 0.20019744270332 no 708 0.198064161090384 983 3125804
SGTC_1302 1159-0335 255 µM 0.847633232750379 0.200454858536785 no 709 0.19832113026747 941 649284
SGTC_2616 abietic acid 100 µM 0.846776636217709 0.200693957306775 no 710 0.198559816624175 1021 6708678 Abietic acid is an inhibitor of 5α-reductase.
SGTC_2829 7992743 58.44 µM 0.844358965595654 0.201369716070832 no 711 0.199234422577221 1001 16462845
SGTC_2665 lovastatin 100 µM 0.843729330278174 0.20154592789022 no 712 0.199410336885352 984 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1
SGTC_1764 st044502 93.5 µM 0.842657769924327 0.20184603063223 no 713 0.199709935884596 971 8407
SGTC_2870 9038528 12.99 µM 0.841246207278456 0.202241763002644 no 714 0.20010500965037 891 6463316
SGTC_744 1594-0068 283 µM 0.840458599010352 0.20246277100335 no 715 0.20032565263075 1003 668392
SGTC_2382 9035899 200 µM 0.83964122170164 0.202692285015383 no 716 0.200554789691502 980 6462679
SGTC_1779 st039427 55 µM 0.838061541234339 0.203136288953514 no 717 0.200998070516453 1069 1124498
SGTC_151 3013-0144 2.285 µM 0.835974709857702 0.20372372813738 no 718 0.201584565343504 978 906558 YHR107C CDC12
SGTC_2361 9034121 116 µM 0.835194695464558 0.203943560519931 no 719 0.201804047938115 966 6496917
SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM 0.834486531547871 0.204143265567316 no 720 0.202003436924679 829 4000243
SGTC_2781 5567276 71.43 µM 0.834484195988761 0.20414392439694 no 721 0.202004094714293 968 2853274
SGTC_3318 9139014 38.6185 µM 0.832452248700801 0.204717588941729 no 722 0.202576860362897 962 16643984
SGTC_1722 st034304 3.6505 µM 0.831859550508557 0.204885101480725 no 723 0.202744112932114 991 4036148 YLR033W RSC58
SGTC_2969 9091408 28.7 µM 0.831012157859692 0.205124739071678 no 724 0.202983380589568 926 4286311
SGTC_3095 9117207 49.47 µM 0.830430087865251 0.20528944145723 no 725 0.203147830063932 961 17015229
SGTC_3263 9137018 49.47 µM 0.830418211136173 0.205292802911273 no 726 0.20315118636763 967 43844957
SGTC_2585 alliin 100 µM 0.828736115474653 0.205769214273569 no 727 0.203626872384277 1011 87310 A garlic compound which reacts with lipids.
SGTC_1691 st019933 84.6 µM 0.825891008809279 0.206576510923527 no 728 0.204432960719373 1007 6176082
SGTC_2004 4023728 41.89 µM 0.824999586621105 0.206829836679724 no 729 0.204685912691715 1019 360084 YDR527W RBA50
SGTC_3097 9117246 49.47 µM 0.824983029143363 0.206834543748614 no 730 0.204690612839561 1053 16423892
SGTC_1049 3226-0134 66 µM 0.823889202900528 0.207145644325921 no 731 0.205001257950774 1025 5702385
SGTC_2807 7945238 51.95 µM 0.823515112010454 0.207252104867314 no 732 0.205107563515401 994 17148797
SGTC_1129 3453-1384 223 µM 0.822428965602105 0.207561388808152 no 733 0.205416399786146 1013 1084452
SGTC_1578 josamycin 24.2 µM 0.821231688534846 0.207902633429369 no 734 0.20575715489076 929 5282165 A P450 substrate.
SGTC_3150 9097574 49.47 µM 0.821199918196752 0.207911693033498 no 735 0.20576620156189 997 17217476
SGTC_1951 sophoraflavanone G 9.2 µM 0.820748230569773 0.208040521129218 no 736 0.205894846102107 1010 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity.
SGTC_645 0845-0943 5.41 µM 0.819292962177264 0.208455905877799 no 737 0.206309643487671 978 1885106
SGTC_750 4073-0104 132 µM 0.818155651975085 0.208780874403948 no 738 0.206634157262683 858 22330957
SGTC_1342 1486-1464 234 µM 0.817923501959764 0.20884724429316 no 739 0.206700434789107 1020 3253938
SGTC_2995 9067767 71.4286 µM 0.816665293756672 0.209207172464713 no 740 0.207059865098939 957 11673567
SGTC_1243 0416-0003 5.65 µM 0.814927838698427 0.209704795774725 no 741 0.207556808489509 998 2141977
SGTC_3316 9136639 10.545 µM 0.812534221802519 0.210391488632038 no 742 0.208242579067852 1011 4903665
SGTC_1966 st070145 16.1 µM 0.811878384669927 0.210579868635368 no 743 0.208430709292216 1019 3748532
SGTC_1038 k292-0204 154 µM 0.811018903230754 0.21082689239475 no 744 0.208677407617508 964 4454212
SGTC_1471 k673-0312 37 µM 0.808982364365795 0.211412892471137 no 745 0.209262645209589 1050 24099884
SGTC_866 0495-0101 262 µM 0.808723340103827 0.211487493243606 no 746 0.209337149873809 954 635694
SGTC_3205 9113483 49.47 µM 0.807529657628268 0.211831481162033 no 747 0.209680697431471 1031 17018033
SGTC_3017 9080681 49.47 µM 0.805419280772727 0.212440436636396 no 748 0.210288884602834 999 16451914
SGTC_140 0062-0056 502.533 µM 0.804902005594199 0.212589853836309 no 749 0.210438115481112 1092 3758964
SGTC_1949 st076024 69.1 µM 0.804197689359212 0.212793397311725 no 750 0.210641406528599 1068 2921930
SGTC_418 lividomycin a 100 µM 0.803446087377623 0.213010731530858 no 751 0.210858472983054 1078 72394 An antibiotic.
SGTC_3034 9090421 49.47 µM 0.802054498987444 0.213413466763198 no 752 0.211260716843191 998 17173761
SGTC_734 2023-0417 80 µM 0.80106766595877 0.213699331796063 no 753 0.211546236884083 1007 3935732
SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM 0.799863837515819 0.214048357725567 no 754 0.211894845853201 1012 6708760
SGTC_2820 7989630 71.43 µM 0.798200079585793 0.214531276714247 no 755 0.212377195628494 943 2984098
SGTC_1178 0988-0033 191 µM 0.797109614605821 0.214848136185007 no 756 0.212693686466278 1054 5392207
SGTC_1424 4048-1941 275 µM 0.796185905178525 0.215116753584509 no 757 0.212961994359584 1112 X1424
SGTC_2570 licareol 100 µM 0.795990807794717 0.215173513402261 no 758 0.213018689129696 971 443158
SGTC_1021 4476-0760 85.3 µM 0.794735898371134 0.215538812810633 no 759 0.213383572835103 1048 746768
SGTC_1313 1220-0047 237 µM 0.79470106409221 0.215548958065934 no 760 0.213393706617792 1068 3528706
SGTC_1414 3917-0015 5.4 µM 0.793375844213624 0.215935125295868 no 761 0.213779440064046 1054 6618702
SGTC_1828 st055811 49 µM 0.793360729038035 0.215939532147882 no 762 0.213783841998499 1016 5877589
SGTC_1189 1431-2119 7.28 µM 0.792763490038355 0.216113699772699 no 763 0.213957815861316 1067 3107275
SGTC_730 1436-0052 41.2 µM 0.790637927902724 0.216734218649908 no 764 0.214577653748172 1071 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2
SGTC_92 0063-0024 660.874 µM 0.790303295282735 0.216832002292017 no 765 0.214675331405312 1138 3594437
SGTC_1228 0124-0032 52.5 µM 0.790012911838332 0.216916876464052 no 766 0.214760113877273 1086 X1228
SGTC_2157 5649910 96.377 µM 0.785713068593177 0.218175893609433 no 767 0.216017802608699 1036 2858091
SGTC_2736 butenafine 14.65 µM 0.784981253590214 0.218390591549302 no 768 0.216232279956976 1063 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_2954 9074818 52.69 µM 0.782227082326556 0.219199692975599 no 769 0.217040565558566 1033 16648742
SGTC_2295 7971645 200 µM 0.781487264006878 0.219417324945995 no 770 0.217257982256774 1037 2978226 YKL099C UTP11
SGTC_187 1488-2104 32.728 µM 0.779424939930014 0.220024652723508 no 771 0.217864718609829 1114 2852859
SGTC_2246 7293507 91.5585 µM 0.778849601449638 0.220194254364468 no 772 0.218034157536491 1108 887656
SGTC_42 0133-0086 60.653 µM 0.77674149339536 0.22081633503663 no 773 0.218655650509474 1051 162923 Model of phenazepam hydroxylation.
SGTC_2133 5320837 200 µM 0.776308958072567 0.220944096000498 no 774 0.218783292544509 1026 2841355
SGTC_273 hydroxyurea 18.1 mM 0.775531005377929 0.221173991754724 no 775 0.219012975812982 1152 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12
SGTC_2310 7668677 200 µM 0.772481848117075 0.222076378049225 no 776 0.219914546870231 1071 2197143
SGTC_3287 9117173 37.0625 µM 0.772431191672693 0.222091387354308 no 777 0.219929542868529 1066 2789709
SGTC_2486 5283202 22.39 µM 0.771030158464486 0.22250673739372 no 778 0.220344527947613 1025 1377751
SGTC_1505 k297-0037 20.6 µM 0.770863504549481 0.22255617304272 no 779 0.220393920579188 1072 4089396
SGTC_1774 st048371 48.465 µM 0.769814673832784 0.22286743829777 no 780 0.220704917033591 1099 4242727
SGTC_2751 anetholtrithion 17.25 µM 0.769210757929471 0.223046777049108 no 781 0.220884102519951 1043 2194 A chloretic substance that stimulates the liver to produce bile.
SGTC_120 rhodamine 6G 52.259 µM 0.769007653349504 0.223107109408442 no 782 0.220944383582448 1176 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase
SGTC_1187 1391-0724 117 µM 0.767806586996078 0.223464076909849 no 783 0.221301050292363 1098 6997986
SGTC_2566 crystal violet carbinol 226 nM 0.764858491421264 0.224341653051351 no 784 0.222177906666994 1038 68050 Cationic dye that binds acidic phospholipids including cardiolipin.
SGTC_1575 cyproterone acetate 48 µM 0.762194130269947 0.225136448593276 no 785 0.222972074423807 1063 9880 An androgen receptor antagonist and liver toxin.
SGTC_2245 6637752 200 µM 0.761524668203937 0.225336403783477 no 786 0.223171875267762 1051 681890
SGTC_2706 st078239 82.5 µM 0.76016338525815 0.225743302278212 no 787 0.223578464124282 1120 15434492
SGTC_323 4013-0906 34.3 µM 0.760069978163904 0.225771237644929 no 788 0.223606378451562 1122 2910086
SGTC_424 splitomicin 100 mM 0.759414018932316 0.225967471197683 no 789 0.223802465002285 1022 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_1822 st052468 42 µM 0.759305496425157 0.225999945553398 no 790 0.22383491516432 1104 2873678
SGTC_610 4215-0184 155 µM 0.759178988060818 0.226037805340597 no 791 0.223872746793462 1093 5605015
SGTC_2119 5528445 120.635 µM 0.758445650108912 0.226257339849809 no 792 0.224092119039004 1087 791935
SGTC_3128 9127691 49.47 µM 0.75669824389535 0.226780934417675 no 793 0.224615333578279 999 41316314
SGTC_2474 5321570 43.32 µM 0.755966886847771 0.227000281763726 no 794 0.224834524636229 1105 2841384
SGTC_386 1509-0011 3.07 µM 0.755595772064642 0.227111631610179 no 795 0.224945795802171 1158 3107280
SGTC_2183 6420625 130.508 µM 0.75547310156483 0.227148444624421 no 796 0.224982582901478 1155 2897619
SGTC_84 0443-0269 128.823 µM 0.754613183500466 0.227406597624817 no 797 0.225240555530626 1082 6150058
SGTC_3232 9132874 49.47 µM 0.753629971758505 0.227701966602089 no 798 0.225535721047538 1099 3784940
SGTC_3350 9150499 3.57 µM 0.752501772839279 0.228041157434587 no 799 0.225874682063352 1130 4910996 YPR165W RHO1
SGTC_1864 st057645 30.4 µM 0.751668704915967 0.228291799984103 no 800 0.226125157417838 1147 688666
SGTC_2705 st078069 42.8 µM 0.751355749918194 0.228385997774024 no 801 0.226219292948007 1067 1530061
SGTC_1915 st067105 30.6 µM 0.749519638025715 0.228939097456771 no 802 0.226772033403404 1135 69751 YOR207C | YOR116C RET1 | RPO31
SGTC_2065 5221596 34.26 µM 0.747858013663775 0.229440282766527 no 803 0.227272902544453 1082 788581
SGTC_2694 st077685 81.9 µM 0.745708808754421 0.230089444991152 no 804 0.227921668412216 1123 2838096
SGTC_1841 st054148 70 µM 0.745123846289029 0.230266309263052 no 805 0.228098427265574 1062 675442
SGTC_2219 9098279 200 µM 0.744994631874224 0.230305387683684 no 806 0.228137482541983 1128 902349
SGTC_1163 k060-0048 49.9 µM 0.743969097732986 0.230615672298191 no 807 0.228447585291617 1159 6809982
SGTC_722 3534-0461 190 µM 0.74347526946946 0.230765167778953 no 808 0.22859699435426 1131 658262
SGTC_717 1532-0246 73.2 µM 0.741288820408983 0.231427716384204 no 809 0.229259169373395 1110 9561992
SGTC_3216 9129716 49.47 µM 0.740503328055517 0.231665998889723 no 810 0.229497321267788 1092 8056934
SGTC_2756 carbadox 75.1 µM 0.739176535910453 0.232068797363422 no 811 0.229899903451021 1115 2553 A substituted quinoxaline antibiotic. YLR208W SEC13
SGTC_246 cycloheximide 667 µM 0.739034597393121 0.232111911299447 no 812 0.229942994570633 1040 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells.
SGTC_2918 7977171 22.06 µM 0.738650324058172 0.232228656998228 no 813 0.23005967881054 1104 2236483
SGTC_1615 st002656 86.5 µM 0.738473902788604 0.232282266310629 no 814 0.230113260059852 1141 1584458
SGTC_755 1995-0008 37.3 µM 0.736952252670407 0.232744937397733 no 815 0.230575693095819 1152 689533
SGTC_3135 9127742 49.47 µM 0.736916763014927 0.232755734447486 no 816 0.230586484678959 1058 3643468
SGTC_2311 7694451 200 µM 0.735762964571834 0.233106907167032 no 817 0.230937481798272 1083 2163142
SGTC_2123 5259487 200 µM 0.735683545539384 0.23313109014082 no 818 0.230961652836658 1128 2173474
SGTC_3235 9132602 49.47 µM 0.735642717010108 0.233143522907523 no 819 0.230974079475095 1168 4912240
SGTC_1351 1496-0003 46.5 µM 0.733449160432751 0.233812027515951 no 820 0.231642262429514 1157 3891978
SGTC_2446 5162541 200 µM 0.732228320932598 0.234184548162494 no 821 0.232014610520082 1077 1549321
SGTC_540 1187-0821 17.3 µM 0.730524447104844 0.234705008313514 no 822 0.232534837576321 1122 847520
SGTC_1970 st070122 35.8 µM 0.730142605527782 0.234821732148794 no 823 0.232651510411454 1173 102928
SGTC_2899 9053889 58.44 µM 0.729279287429927 0.235085755127057 no 824 0.23291541975227 1120 6470052
SGTC_3183 9108214 49.47 µM 0.728299142277842 0.235385705221583 no 825 0.233215243640562 1058 4974831
SGTC_2393 9031399 185.94 µM 0.726319513515627 0.235992167138502 no 826 0.233821459770737 1165 1526623 YDL150W RPC53
SGTC_2853 9015042 58.44 µM 0.726312744496699 0.235994242312598 no 827 0.233823534125336 1113 6457456
SGTC_689 0833-0039 98 µM 0.726267088819484 0.236008239208975 no 828 0.2338375254981 1153 5374726
SGTC_2280 7785178 200 µM 0.724967045487436 0.236406992109017 no 829 0.234236123838668 1133 2954328
SGTC_1601 4'-hydroxyflavanone 55.5 µM 0.72428750072648 0.236615571465192 no 830 0.234444624501438 1172 165506
SGTC_2034 5197015 53.07 µM 0.722153299399696 0.23727130070571 no 831 0.235100115959935 1142 780676
SGTC_3144 9087057 49.47 µM 0.720743658244897 0.237704956955442 no 832 0.235533622951442 1100 17249618
SGTC_2547 epiafzelechin trimethyl ether 100 µM 0.719015711622244 0.238237128040121 no 833 0.236065619544709 1029 6708630 An antioxidant.
SGTC_1029 k015-0030 64.7 µM 0.718680953434675 0.238340301915845 no 834 0.236168760695382 1122 2208316
SGTC_1671 st016596 74.5 µM 0.718475590902342 0.238403607617521 no 835 0.236232046494851 1208 2829167
SGTC_1843 st055809 45.5 µM 0.718301979058545 0.238457132933292 no 836 0.236285555088371 1132 16413835
SGTC_2417 cerulenin 830 nM 0.718085705712952 0.238523820185238 no 837 0.236352221640826 1164 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1
SGTC_3043 9092303 49.47 µM 0.716692803336967 0.238953562065258 no 838 0.236781833713867 1132 25236084
SGTC_1791 st048313 56.1 µM 0.71603437321743 0.239156849911806 no 839 0.236985062314628 1109 1204976
SGTC_1627 st003713 25.6 µM 0.714369874480193 0.239671178908169 no 840 0.237499247595846 1210 16195070 YER133W GLC7
SGTC_2312 7706453 155.7 µM 0.710603790500707 0.240837121176428 no 841 0.238664896768952 1181 976098
SGTC_2978 9011784 42.97 µM 0.710440883920176 0.240887624974751 no 842 0.238715388893842 1232 2994934
SGTC_3230 9131665 49.47 µM 0.70997946275397 0.241030704613266 no 843 0.238858435920766 1120 15943720
SGTC_2651 TUB2.036 5 µM 0.709949779401328 0.241039910548233 no 844 0.238867639780724 1279 15992207 YFL037W TUB2
SGTC_735 3076-0345 636 µM 0.709195644095091 0.24127386066881 no 845 0.239101538112546 1199 2888990
SGTC_2825 7998094 58.44 µM 0.708643568109986 0.241445205540797 no 846 0.239272846205321 1133 2987815
SGTC_2986 9022445 71.43 µM 0.708072274774588 0.241622584363438 no 847 0.239450187977598 1145 6459286
SGTC_283 0987-0079 11.7 µM 0.707192751639674 0.241895802600197 no 848 0.239723351181289 1206 411556
SGTC_2444 5485484 36.41 µM 0.7069898907863 0.241958843806372 no 849 0.239786380039624 1203 6790631
SGTC_929 2805-0021 398 µM 0.705788573310646 0.242332348800602 no 850 0.240159814566491 1167 3098024
SGTC_1398 3558-0053 112 µM 0.704537092780697 0.24272178217039 no 851 0.240549179360042 1110 4532369
SGTC_2294 7971431 200 µM 0.704354874883776 0.242778512635231 no 852 0.240605900251608 1103 5741572
SGTC_380 3970-0968 6 µM 0.702314612424594 0.243414203651822 no 853 0.241241491225324 1159 2891601
SGTC_2511 berberine 10.47 µM 0.701797600400433 0.243575433426702 no 854 0.241402697733841 1187 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_2626 ethyl orsellinate 100 µM 0.700631505179118 0.243939290909976 no 855 0.241766505837904 1187 75653 A natural product.
SGTC_1995 st072814 61.1 µM 0.699977786775104 0.244143399320256 no 856 0.241970588443845 1154 5769371
SGTC_2127 5253358 187.912 µM 0.699550957647972 0.244276716494663 no 857 0.242103889498241 1144 20612
SGTC_2867 9039098 71.43 µM 0.698519449836514 0.244599062890353 no 858 0.242426199313284 1186 6463460
SGTC_446 go6976 132 µM 0.697193047700019 0.245013900289243 no 859 0.242840994616111 1161 3501 A protein kinase C inhibitor.
SGTC_776 4476-4378 112 µM 0.695809969089273 0.245446866253473 no 860 0.243273922611144 1160 2892008
SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM 0.694446261829952 0.245874170303113 no 861 0.243701195150205 1249 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W
SGTC_1251 0490-5699 265 µM 0.694246116827908 0.245936917322301 no 862 0.243763938040197 1243 3883818
SGTC_661 1304-0007 33.6 µM 0.693965871573147 0.246024790832953 no 863 0.243851805982274 1200 3117130
SGTC_2328 6201408 200 µM 0.692469601623368 0.246494245133807 no 864 0.24432123476194 1169 2890418
SGTC_1288 0973-0013 65.5 µM 0.692156791947395 0.246592449711081 no 865 0.244419434900373 1222 4315430
SGTC_1897 st060201 15 µM 0.691861443797606 0.246685191586997 no 866 0.244512172869908 1209 611878
SGTC_414 piperonyl butoxide 100 µM 0.691417315236381 0.246824686955327 no 867 0.244651662884636 1192 5794 A potent inhibitor of cytochrome P450.
SGTC_286 k060-0067 22.9 µM 0.689489782624378 0.247430590461096 no 868 0.245257550404947 1180 5985051
SGTC_2861 9024595 19.48 µM 0.688668291504756 0.247689060585988 no 869 0.245516017299908 1150 16482810
SGTC_2717 st081029 62.2815 µM 0.688267210503116 0.247815307203181 no 870 0.245642263118456 1188 5292846
SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM 0.686178043543322 0.248473460811018 no 871 0.246300420828122 1176 2724278 An inhibitor of dopamine biosynthesis.
SGTC_61 0978-8327 98.565 µM 0.686000518545867 0.24852942970075 no 872 0.246356390705668 1237 6150059 YHR072W ERG7
SGTC_3094 9117742 49.47 µM 0.685081719146951 0.248819209923937 no 873 0.246646177642375 1189 17149698
SGTC_854 0422-0053 192 µM 0.684232996785915 0.249087048282341 no 874 0.246914024587199 1222 3596728
SGTC_1438 4092-1045 4 µM 0.683799233024021 0.249223993913559 no 875 0.247050975491436 1204 1351342
SGTC_2213 7173844 200 µM 0.683692828179699 0.249257593610153 no 876 0.247084576572957 1203 892728
SGTC_3137 9097352 49.47 µM 0.682779416461166 0.249546122736729 no 877 0.247373119070156 1310 44120435
SGTC_475 α-linolenic acid 10 µM 0.682051601454407 0.249776152410904 no 878 0.247603161299032 1299 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_1248 0469-0687 58.6 µM 0.681578824781963 0.249925636206461 no 879 0.247752654153442 1207 4017482
SGTC_344 k064-0035 6.43 µM 0.680821772540916 0.250165101867284 no 880 0.24799213580255 1190 5088750
SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM 0.6804650455967 0.25027798149633 no 881 0.248105023598112 1279 5024745
SGTC_579 4491-1009 110 µM 0.679564021949157 0.250563213936069 no 882 0.248390278470209 1352 1271041
SGTC_1679 SEC14.276 6.7 µM 0.678588604427001 0.250872190892944 no 883 0.248699282628189 1250 1005053 YMR079W SEC14
SGTC_3015 9080845 49.47 µM 0.676546976565409 0.251519556972601 no 884 0.249346715462559 1262 5296973
SGTC_2745 rifampicin 24.3 µM 0.675865086948252 0.251735969242445 no 885 0.24956315299037 1149 25141428 Inhibits bacterial DNA-dependent RNA polymerase.
SGTC_1634 st006576 41 µM 0.674428914097215 0.25219209088338 no 886 0.250019332683621 1224 3915356
SGTC_1954 st077032 68.9 µM 0.673205285428531 0.252581053104525 no 887 0.250408349562283 1159 698907
SGTC_2467 5474540 200 µM 0.673078728457096 0.252621300557855 no 888 0.250448602941641 1222 5413519
SGTC_2654 protoveratrine a 100 µM 0.672540945372294 0.252792363176416 no 889 0.250619691312666 1210 5702278 A heart drug and vasodilator.
SGTC_1649 st011737 51.3 µM 0.672349403761518 0.25285330508699 no 890 0.250680642618674 1211 1761035
SGTC_1132 3456-3614 2.5 µM 0.670259950841851 0.253518598683017 no 891 0.25134604632374 1287 3125502
SGTC_2980 9014342 25.29 µM 0.67003227109476 0.253591148727715 no 892 0.251418609210112 1244 2996599
SGTC_35 0133-0054 64.071 µM 0.669346111579457 0.253809859079453 no 893 0.251637359265791 1182 99677
SGTC_1380 2291-0730 164 µM 0.667180610046988 0.254500752117403 no 894 0.252328387489239 1230 2999191
SGTC_3330 9141424 71.43 µM 0.666678850617421 0.254660976586565 no 895 0.252488645423962 1242 27261020
SGTC_3251 9135047 49.47 µM 0.665510359506029 0.255034309992535 no 896 0.252862059889642 1237 17682963
SGTC_3296 9122258 64.045 µM 0.663109851431591 0.255802170700122 no 897 0.253630100850482 1245 4730474
SGTC_2862 9027634 71.43 µM 0.662575687180369 0.255973200085531 no 898 0.253801172858938 1197 5012562
SGTC_1836 st055642 81 µM 0.662505500583348 0.255995676952703 no 899 0.25382365539459 1223 8571
SGTC_815 1582-0027 36.9 µM 0.662487944381108 0.256001299389775 no 900 0.253829279252024 1273 3128206
SGTC_1717 st033143 58.0435 µM 0.660035489211858 0.256787339609054 no 901 0.254615527601189 1277 674616
SGTC_1066 ketoconazole 628 nM 0.658231799674467 0.257366243655251 no 902 0.25519459703959 1282 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W
SGTC_2920 7982904 15.77 µM 0.657844162667507 0.257490746356993 no 903 0.255319136650294 1230 6456808
SGTC_973 1325-0077 65.9 µM 0.65777675713527 0.257512399110376 no 904 0.255340795870976 1288 2835149
SGTC_223 busulfan 5 mM 0.656170613817505 0.258028621925709 no 905 0.255857177107668 1253 2478 A DNA alkylator.
SGTC_153 4077-0274 519.67 µM 0.656113306060467 0.258047050848825 no 906 0.255875611836485 1367 3121976
SGTC_2742 clothiapine 36.27 µM 0.656052186268852 0.258066706391238 no 907 0.25589527358242 1211 16351 An atypical antipsychotic. YIL048W NEO1
SGTC_691 1548-0686 185 µM 0.655065380389494 0.258384161188678 no 908 0.256212830200501 1227 46495133
SGTC_927 2425-1185 123 µM 0.655009312339678 0.258402204315805 no 909 0.256230879206833 1242 730375
SGTC_2032 5185112 25.99 µM 0.651570217539974 0.259510178024562 no 910 0.25733923286444 1202 5718189
SGTC_2360 9040895 200 µM 0.651326544262334 0.259588775254041 no 911 0.257417858458516 1228 4914414
SGTC_1400 3771-8998 51.5 µM 0.649443124813457 0.260196689753208 no 912 0.258025998644541 1222 670767
SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM 0.649054880582668 0.260322095154928 no 913 0.258151451988956 1236 756377
SGTC_3335 9143315 29.6265 µM 0.648985084227974 0.260344643131385 no 914 0.258174008635766 1254 4899691
SGTC_2976 9009005 19.48 µM 0.647164148130576 0.260933258754349 no 915 0.258762856007959 1295 2993148
SGTC_2834 9001755 58.44 µM 0.644038011601701 0.261945372661138 no 916 0.259775392700072 1244 2989575
SGTC_618 k072-0232 33.2 µM 0.641694135552202 0.262705541150549 no 917 0.260535898857033 1274 5872756 YGL099W LSG1
SGTC_1651 st011928 86.1 µM 0.639658595640092 0.263366624149693 no 918 0.261197289490032 1289 720198
SGTC_2662 daunorubicin 22.37 µM 0.63912900526412 0.263538758534081 no 919 0.26136950610539 1241 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_2506 ethyl hematommate 54.16 µM 0.638089278462524 0.263876871052544 no 920 0.261707782700289 1246 3940691 An allergen.
SGTC_2671 danthron 100 µM 0.637910027997584 0.263935184500963 no 921 0.26176612478867 1239 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin.
SGTC_2702 st077768 96.8 µM 0.636589050467385 0.264365125075732 no 922 0.262196279625995 1219 6484119
SGTC_3237 9133362 49.47 µM 0.636071927776767 0.264533530837317 no 923 0.262364770800809 1259 43845137
SGTC_3073 9114972 49.47 µM 0.63425014108215 0.265127246980333 no 924 0.262958794735905 1236 41905075
SGTC_1219 1469-0211 33.1 µM 0.633367495902852 0.265415142224954 no 925 0.263246842963364 1265 6822282
SGTC_3176 9106582 49.47 µM 0.632311784653588 0.265759695216722 no 926 0.263591582243808 1208 17018027
SGTC_1653 st012112 65 µM 0.629814999306281 0.266575473515402 no 927 0.264407815469962 1316 720429
SGTC_2255 7941087 197.44 µM 0.629573008458062 0.26665460679598 no 928 0.264486993915084 1329 935561
SGTC_2049 5262831 67.185 µM 0.626902490819495 0.2675286790963 no 929 0.265361577225807 1328 763417
SGTC_2828 7998861 71.43 µM 0.626287088117671 0.267730307757823 no 930 0.265563326920801 1241 2988188
SGTC_1079 idarubicin 2.36 µM 0.626234688174168 0.267747479452255 no 931 0.265580508977599 1286 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_1364 1653-0028 37.6 µM 0.625793471722943 0.26789209005061 no 932 0.265725207181625 1292 5718652
SGTC_2789 5281112 71.43 µM 0.625126882347615 0.268110642183797 no 933 0.265943892865654 1289 765948
SGTC_919 tnp00227 403.569 nM 0.62346736854134 0.268655130219704 no 934 0.266488719638971 1327 1269246 A methoxyflavone. YNL221C POP1
SGTC_643 k048-0106 28.4 µM 0.623448466088073 0.26866133533133 no 935 0.26649492866035 1344 6763920
SGTC_1693 xanthone 101.9 µM 0.623144161205317 0.268761239458728 no 936 0.266594895889099 1349 7020 An insecticide.
SGTC_2205 7238770 200 µM 0.620667138758844 0.26957514627894 no 937 0.267409327518479 1341 279867
SGTC_1352 1496-0991 99 µM 0.620509163295671 0.269627096153629 no 938 0.267461311538504 1305 3000039
SGTC_2991 9074669 71.4286 µM 0.62025800972019 0.269709697764456 no 939 0.267543967601124 1354 17333109
SGTC_168 3970-0862 530.542 µM 0.619902856040089 0.269826525479851 no 940 0.267660872665453 1323 3135186
SGTC_1770 st043884 66.3 µM 0.619740771275764 0.26987985164208 no 941 0.267714234264097 1300 670149
SGTC_1272 0839-0021 27 µM 0.619265750974294 0.270036164507799 no 942 0.267870651473841 1328 5027250
SGTC_2891 9063876 19.48 µM 0.618899198364096 0.270156815339192 no 943 0.267991383323368 1280 6472478
SGTC_1137 ixabepilone 100 µM 0.614457754446008 0.271620856254523 no 944 0.269456440567441 1317 154225 A novel microtubule stabilizer.
SGTC_886 0866-0150 153 µM 0.614318953938801 0.271666672885565 no 945 0.269502289991798 1349 271463
SGTC_464 bw-b 70c 158 µM 0.614122129894192 0.271731649089642 no 946 0.269567312805203 1345 5353454
SGTC_192 3455-0609 60.9 µM 0.614064446525841 0.271750693179398 no 947 0.269586370578623 1340 3769639
SGTC_3323 9138564 53.9225 µM 0.613698010945402 0.271871686925453 no 948 0.269707451502942 1326 43912313 YNL103W MET4
SGTC_1267 0828-0272 9.49 µM 0.611755597057478 0.272513501832755 no 949 0.270349735809749 1391 745334
SGTC_1807 st050092 58.9 µM 0.610219723814707 0.273021519098564 no 950 0.270858132907478 1298 5008496
SGTC_677 0929-0063 136 µM 0.600547806865395 0.276231423126342 no 951 0.27407060503018 1315 1539583
SGTC_954 1189-0853 2.85 µM 0.600009575861391 0.276410593095903 no 952 0.274249926846631 1324 2828194
SGTC_2981 9013952 38.96 µM 0.599114229286488 0.276708768317219 no 953 0.274548356753005 1242 2996344
SGTC_1184 1269-1718 139 µM 0.597390033895358 0.277283416767645 no 954 0.275123503006009 1413 5403821
SGTC_997 3996-0078 137 µM 0.59718781671741 0.277350850939826 no 955 0.275190996195325 1361 735687
SGTC_839 0122-0028 230 µM 0.597116020317592 0.277374795101645 no 956 0.275214961342953 1337 759448
SGTC_2518 prenyletin 46.28 µM 0.595674212252016 0.277855853175892 no 957 0.275696444403331 1287 3873459 A coumarin with calcium channel inhibitory activity.
SGTC_2425 5628681 7.85 µM 0.594217518730614 0.278342291023549 no 958 0.276183318496096 1348 5714958
SGTC_1604 st002052 72.4 µM 0.59311685285852 0.278710114631214 no 959 0.276551476308491 1371 6254834 YHR062C RPP1
SGTC_2159 5658611 73.75 µM 0.592861157833765 0.278795597371114 no 960 0.276637037251824 1358 793844
SGTC_2033 5192550 145 µM 0.592307955895884 0.278980584858652 no 961 0.276822194662688 1323 182073
SGTC_271 rotenone 740 µM 0.592057722997521 0.279064280880554 no 962 0.276905967874233 1380 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria.
SGTC_842 0271-0008 11.1 µM 0.590754494020619 0.279500372409289 no 963 0.277342464707499 1408 1221709
SGTC_920 mycophenolic acid 780.421 nM 0.590013166393254 0.279748585902821 no 964 0.277590911221799 1355 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_721 1187-1332 279 µM 0.589982269472168 0.279758933221891 no 965 0.277601268291515 1294 25730
SGTC_592 k241-0073 46.5 µM 0.589489834770622 0.279923873709953 no 966 0.277766364604844 1400 4230158
SGTC_2253 7938677 135.83 µM 0.589244504682336 0.280006064361469 no 967 0.277848633182942 1464 2301972
SGTC_773 4358-1457 44.6 µM 0.588297444466343 0.280323458822909 no 968 0.278166330307157 1381 1186886
SGTC_2948 9070189 9.45 µM 0.587664590424342 0.280535648392307 no 969 0.278378723753076 1309 6473636 YDL196W YDL196W
SGTC_3132 9126706 49.47 µM 0.587061378127568 0.280737971711498 no 970 0.278581242613803 1365 850858
SGTC_3123 9126162 49.47 µM 0.584012616480901 0.28176163455889 no 971 0.279605911902513 1404 25239884
SGTC_2507 purpurin 79.67 µM 0.583517451801526 0.281928062461164 no 972 0.279772506124198 1329 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1
SGTC_1551 6-bromo-3'-methylflavone 63.5 µM 0.582638947683432 0.28222344960379 no 973 0.280068190310722 1406 688751
SGTC_1200 1643-0193 18.4 µM 0.582018984797595 0.282431994768998 no 974 0.280276946613964 1353 5403974
SGTC_817 1391-0715 46 µM 0.580882115135349 0.282814611202015 no 975 0.280659953479335 1332 1353946
SGTC_1670 st016595 4.04 µM 0.580741370828392 0.282861996377848 no 976 0.280707387283575 1360 597879
SGTC_1355 1499-0035 1.68 µM 0.580696392267196 0.282877140366456 no 977 0.280722546826284 1352 1548538
SGTC_2464 5717415 7.67 µM 0.580273581599264 0.283019516994936 no 978 0.28086506998975 1298 5285744
SGTC_136 0097-0015 404.482 µM 0.579995546224718 0.283113160952235 no 979 0.280958810624203 1364 4861337
SGTC_1891 st059073 26.2 µM 0.579728581010937 0.283203090403851 no 980 0.281048833140747 1421 688754
SGTC_3084 9116877 49.47 µM 0.579150715621802 0.283397796085373 no 981 0.281243741063359 1304 27241325
SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM 0.57880541362053 0.283514172596042 no 982 0.281360238942025 1339 689007
SGTC_111 0083-0039 52.457 µM 0.575938077079351 0.284481429488886 no 983 0.282328518665139 1303 759313
SGTC_3208 9114115 49.47 µM 0.573883735936926 0.285175401341311 no 984 0.283023239811938 1314 650895
SGTC_2569 tetrandrine 100 µM 0.573037215491989 0.285461596835563 no 985 0.283309748064861 1333 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_836 0330-0104 1.35 µM 0.572124663130131 0.285770269785734 no 986 0.283618760785791 1388 46494820
SGTC_2591 skatole 100 µM 0.571148185904864 0.286100741187179 no 987 0.283949598764872 1391 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite.
SGTC_1860 st056228 74.6 µM 0.57088140493793 0.286191060043538 no 988 0.284040018313478 1352 688679
SGTC_5 0352-0601 109.883 µM 0.570736472033956 0.286240132841377 no 989 0.284089145911179 1324 762456
SGTC_1496 4469-0713 57.4 µM 0.570042008452014 0.286475326529587 no 990 0.284324603129449 1411 746691
SGTC_1872 amphotericin b 148 nM 0.570019941629006 0.286482801394133 no 991 0.284332086393518 1376 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1
SGTC_3214 9129694 49.47 µM 0.569532735275946 0.286647860119233 no 992 0.284497330973359 1420 17158655
SGTC_202 3594-0513 34.79 µM 0.569321926390567 0.286719293208602 no 993 0.284568844719828 1367 708429
SGTC_650 1328-0195 38 µM 0.568404851397945 0.287030144415725 no 994 0.284880048492368 1371 2780821
SGTC_17 0960-0276 49.807 µM 0.568222138119706 0.287092095865407 no 995 0.284942070512801 1379 6821114
SGTC_3265 9137266 49.47 µM 0.568003093521106 0.287166374292939 no 996 0.285016433687008 1367 17224265
SGTC_951 1171-0579 82.7 µM 0.56661838571914 0.287636141671067 no 997 0.285486740416614 1341 1616050 YPR165W | YDR526C RHO1 | YDR526C
SGTC_2346 9031566 143.75 µM 0.565755051563262 0.287929214763085 no 998 0.285780152944646 1428 4771086
SGTC_557 1315-0110 16.2 µM 0.565555928381921 0.2879968304329 no 999 0.285847847248202 1361 6833801
SGTC_957 1187-1561 14.1 µM 0.565486043843049 0.288020562695921 no 1000 0.285871607139259 1364 1538454
SGTC_1220 1838-0075 193 µM 0.565182258360798 0.288123736683915 no 1001 0.285974901410264 1337 5529645
SGTC_2957 9076800 11.52 µM 0.564207364779231 0.288454955351134 no 1002 0.286306508115079 1347 16459615
SGTC_1096 rimcazole 32.2 µM 0.561264097301988 0.28945601339325 no 1003 0.287308756458508 1351 18528119 A dopamine reuptake inhibitor.
SGTC_1169 aniline yellow 25.8 µM 0.560619343138191 0.289675523536255 no 1004 0.287528531118997 1404 6051 A DNA damaging agent.
SGTC_103 0844-0104 51.839 µM 0.559917398366213 0.289914593336439 no 1005 0.287767890439892 1423 5375804
SGTC_976 1348-1067 47.6 µM 0.55612083850308 0.291209234386451 no 1006 0.289064125224501 1420 5310671 YGL099W LSG1
SGTC_526 4469-0568 170 µM 0.556041315306496 0.291236380929464 no 1007 0.289091305652205 1389 2901964
SGTC_2746 daunorubicin 9.88 µM 0.555686871469255 0.291357390491537 no 1008 0.289212466492718 1350 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_463 ikarugamyin 104 µM 0.554473411626104 0.291771851576857 no 1009 0.289627448588014 1437 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis.
SGTC_628 1636-0253 16 µM 0.554160993980267 0.291878603274392 no 1010 0.289734335201382 1440 4456143
SGTC_968 1309-0633 340 µM 0.553352640103598 0.292154898538552 no 1011 0.290010981024324 1400 3761976
SGTC_3002 9075603 71.4286 µM 0.551887983623406 0.292655827753636 no 1012 0.290512550839091 1379 20105405
SGTC_1928 4'-methoxychalcone 40.3 µM 0.551711507853608 0.29271621140128 no 1013 0.290573012143965 1549 641818
SGTC_2363 9053361 176 µM 0.550874504989185 0.293002682384038 no 1014 0.290859852826854 1515 6469797 YMR079W SEC14
SGTC_559 1550-0661 158 µM 0.549695562984199 0.293406405285737 no 1015 0.291264100331819 1477 5830875
SGTC_1043 0916-0009 19.3 µM 0.549439827764454 0.293494014560876 no 1016 0.291351824000943 1503 3101130
SGTC_3124 9127567 49.47 µM 0.546822849052309 0.294391229597402 no 1017 0.292250221889457 1483 17592030
SGTC_1031 k035-0009 16 µM 0.544808275324991 0.295082775236636 no 1018 0.292942693288639 1499 5180959
SGTC_1155 4088-0394 48.2 µM 0.544383000159725 0.295228855644039 no 1019 0.293088970812285 1378 2326248
SGTC_2704 st078022 71.1 µM 0.543568722965202 0.295508649623713 no 1020 0.293369143854505 1510 54697681
SGTC_2897 9048598 12.99 µM 0.542563549433646 0.295854205611436 no 1021 0.293715170747263 1385 6467404
SGTC_1815 st051655 58.2 µM 0.542138895298078 0.296000247869834 no 1022 0.293861412936278 1401 5984156
SGTC_2919 7978188 46.38 µM 0.54169040729642 0.296154522724708 no 1023 0.294015899580157 1452 2980291
SGTC_2341 7987486 176.74 µM 0.541120359304918 0.296350666083827 no 1024 0.294212313077164 1499 1258686
SGTC_1001 4048-4355 44.4 µM 0.540427637824384 0.296589099336922 no 1025 0.294451076024674 1398 21824233
SGTC_1772 st048439 82.2 µM 0.53942403794437 0.296934692065829 no 1026 0.294797149177406 1400 2927068 YDL195W SEC31
SGTC_3266 9136860 49.47 µM 0.538837843798441 0.29713663503414 no 1027 0.294999374273217 1371 4871271 YPR165W RHO1
SGTC_2728 chlorpromazine 9.18 µM 0.537128310530501 0.297725924840849 no 1028 0.295589493239373 1439 2726 A thorazine and dopamine antagonist.
SGTC_1126 isoteolin 1.0172 µM 0.535955450986294 0.298130527045031 no 1029 0.295994669803091 1383 133323
SGTC_2148 5546263 113.568 µM 0.535920909679482 0.298142446580824 no 1030 0.296006606321882 1443 792097
SGTC_2583 asiatic acid 100 µM 0.534540725807083 0.298618898823451 no 1031 0.296483740337296 1430 5320556 A kinase inhibitor; arrests cells at G2/M.
SGTC_332 4112-0506 40.9 µM 0.534120296591949 0.2987641036501 no 1032 0.296629154075204 1457 2790355
SGTC_163 TUB2.036 7.546 µM 0.533812606719798 0.298870391703941 no 1033 0.296735595384341 1444 15992207 YJR013W GPI14
SGTC_536 3852-0578 10.6 µM 0.533749372403026 0.29889223742532 no 1034 0.296757472639829 1525 2869208
SGTC_779 1360-0071 233 µM 0.532557954719751 0.299303975064535 no 1035 0.297169806852988 1593 7566
SGTC_2220 6782180 200 µM 0.531689476562703 0.299604271257615 no 1036 0.2974705408235 1415 833803
SGTC_1078 idebenone 36.1 µM 0.531517680612957 0.2996636898081 no 1037 0.297530046262338 1433 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen.
SGTC_2710 st078562 53.7235 µM 0.531366968718499 0.29971582047504 no 1038 0.297582253233047 1395 17250908
SGTC_1979 st071809 45.3 µM 0.530861959448266 0.299890531181669 no 1039 0.29775722015842 1487 4976333
SGTC_665 3914-0008 307 µM 0.529727241604774 0.300283261055685 no 1040 0.29815052876002 1389 1069549
SGTC_39 0986-0283 58.349 µM 0.528406852077292 0.300740544961549 no 1041 0.298608491356216 1545 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2
SGTC_2927 9011802 47.9 µM 0.527415220452486 0.30108417825815 no 1042 0.298952638083244 1380 43912568
SGTC_1421 4029-0249 71.4 µM 0.525512721809853 0.301743952128668 no 1043 0.299613405939672 1530 2894095
SGTC_681 1642-0006 26.6 µM 0.524948480015591 0.301939752328581 no 1044 0.299809503195228 1433 4446530
SGTC_2060 5238662 140 µM 0.524928661407869 0.301946630714429 no 1045 0.299816392033745 1428 790130
SGTC_757 1066-0008 322 µM 0.524772845650932 0.302000711682674 no 1046 0.299870555226284 1509 6842497
SGTC_2054 5233173 129 µM 0.5246161416987 0.30205510531565 no 1047 0.299925031631761 1477 6889
SGTC_443 clozapine 122 µM 0.523909264138593 0.302300524808359 no 1048 0.300170825494782 1427 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_314 1671-0008 2.74 µM 0.523669065226476 0.30238393937757 no 1049 0.300254367645298 1390 3913060
SGTC_581 0958-0271 211 µM 0.522443495628523 0.302809707081025 no 1050 0.300680789223844 1424 4591145
SGTC_117 lucigenin 22.078 µM 0.521988650221575 0.302967790441838 no 1051 0.300839116497563 1403 65100 An acridine derivative; a dye stuff and potential carcinogen.
SGTC_364 0083-0097 67.7 µM 0.521446939220998 0.30315611246368 no 1052 0.301027729890335 1475 5207356
SGTC_799 1310-0557 151 µM 0.520769371860439 0.303391737656041 no 1053 0.30126372086727 1464 5354492
SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM 0.520529651350582 0.303475120460518 no 1054 0.301347233441538 1544 16725076
SGTC_1337 1486-1011 40.3 µM 0.5203355994854 0.303542625680344 no 1055 0.301414843845535 1443 X1337
SGTC_2602 kawain 100 µM 0.520181664402444 0.303596180162084 no 1056 0.301468481853377 1428 5369129
SGTC_982 1491-0518 27.5 µM 0.519868812250656 0.303705035371036 no 1057 0.301577507054668 1439 3091256
SGTC_2299 7976368 114.88 µM 0.519770818716883 0.303739135271778 no 1058 0.30161166026679 1555 2979718
SGTC_1690 st023502 41.2 µM 0.518515721796278 0.304176036306938 no 1059 0.302049246866095 1523 24207482
SGTC_975 1335-0046 28.5 µM 0.517908506782309 0.304387509168106 no 1060 0.302261053236506 1380 16486740
SGTC_2343 7990716 14.84 µM 0.517256731336174 0.304614573751104 no 1061 0.302488477133768 1494 6456862
SGTC_2544 sphondin 68.51 µM 0.516935551631759 0.304726493572837 no 1062 0.302600574523788 1510 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31
SGTC_139 0099-0334 718.624 µM 0.515701617941119 0.305156645963996 no 1063 0.303031412221389 1474 97690
SGTC_1261 0712-0010 12.7 µM 0.514444226325793 0.305595252883922 no 1064 0.303470722552757 1548 2840123
SGTC_3160 9100216 49.47 µM 0.513296608540669 0.305995811846208 no 1065 0.303871927988661 1452 17191039
SGTC_910 3454-3003 490 µM 0.512960975788611 0.306113003370048 no 1066 0.303989309386889 1433 820824
SGTC_1925 st057770 10.1 µM 0.512755212695612 0.306184858646381 no 1067 0.304061281248098 1375 5989122
SGTC_1579 chlormadinone acetate 49.4 µM 0.512556984985556 0.306254089516425 no 1068 0.304130624563196 1550 45114258 A steroidal progestin.
SGTC_222 nsc-310342 10.666 µM 0.51113242114221 0.306751820701406 no 1069 0.304629167578607 1495 432556
SGTC_2249 haloperidol 116.36 µM 0.511068783017514 0.306774063677611 no 1070 0.30465144697426 1492 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_945 3381-0768 11.3 µM 0.510721304295486 0.306895527964268 no 1071 0.304773110350728 1464 1126236 YIL048W NEO1
SGTC_1758 st042942 75.2445 µM 0.509631969455896 0.307276452044179 no 1072 0.305154661104718 1434 669317
SGTC_1749 st037932 54.2 µM 0.50857252732264 0.307647122649454 no 1073 0.305525944872021 1454 594497
SGTC_3282 9108498 15.4605 µM 0.507934214127312 0.30787054631393 no 1074 0.305749739719882 1445 16459645
SGTC_3228 9131799 49.47 µM 0.507845800704374 0.307901498577144 no 1075 0.305780743500052 1502 17015818
SGTC_1226 3909-7979 35.4 µM 0.505703123050197 0.308652036616045 no 1076 0.306532537772885 1539 6615510
SGTC_2260 7964312 200 µM 0.505405511525166 0.308756347457717 no 1077 0.306637024276282 1561 231951
SGTC_376 3970-0862 59.1 µM 0.505261757670586 0.30880673774608 no 1078 0.306687499516272 1552 3135186
SGTC_546 peri-Naphthalide 147 µM 0.504917240404159 0.308927516630698 no 1079 0.306808482266041 1537 223824 A penicillin ester.
SGTC_1192 1488-0095 21.4 µM 0.504894427968966 0.308935514812744 no 1080 0.3068164939607 1490 915875
SGTC_176 1486-1328 72.834 µM 0.504425555939165 0.309099924332607 no 1081 0.306981181582756 1464 22310231
SGTC_1527 coumarin 137 µM 0.503957972073023 0.309263920245972 no 1082 0.307145455542115 1526 323 A hepatotoxic, DNA x-linker.
SGTC_232 clozapine 119 µM 0.503187721467126 0.309534153471201 no 1083 0.307416148333422 1476 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_2309 7664088 163.95 µM 0.5029605520163 0.309613872837025 no 1084 0.307496003604927 1519 704922
SGTC_2640 pentamidine 10.38 µM 0.502481451469393 0.309782030404843 no 1085 0.307664448344723 1530 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_878 0828-0289 13.7 µM 0.50231454195222 0.309840622655679 no 1086 0.30772314081504 1470 745350 YLR208W SEC13
SGTC_1640 st009078 66.4 µM 0.501957975274347 0.309965808718049 no 1087 0.307848541276588 1551 690618
SGTC_307 1501-1223 22.3 µM 0.501845151836663 0.310005424193567 no 1088 0.307888224677016 1461 2830329
SGTC_806 3966-4455 5.86 µM 0.501463106178873 0.310139587525572 no 1089 0.308022618323548 1413 714982
SGTC_2596 sinensetin 100 µM 0.501015866578841 0.310296677191102 no 1090 0.308179978204599 1460 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets.
SGTC_3206 9114350 49.47 µM 0.500470175661904 0.310488394052871 no 1091 0.308372025639859 1439 17087243
SGTC_503 tyrphostin 8 294 µM 0.500084413343935 0.310623954483867 no 1092 0.308507820341668 1532 92970 A tyrosine kinase inhibitor. YOR207C RET1
SGTC_2167 5876490 200 µM 0.499904706799355 0.310687113800582 no 1093 0.308571088957031 1670 686534
SGTC_1173 0443-0020 122 µM 0.498426328731076 0.311206913338253 no 1094 0.309091791611148 1480 5331295
SGTC_2026 5148700 152 µM 0.49840625838823 0.31121397268952 no 1095 0.309098863271599 1458 79838
SGTC_2206 7254556 146.969 µM 0.497701663606089 0.311461844142076 no 1096 0.30934716767776 1521 4398905
SGTC_427 1354-0053 47.3 µM 0.497555838596648 0.31151315502762 no 1097 0.309398568368791 1558 6813657
SGTC_1457 k015-0032 57.3 µM 0.497105122949376 0.311671769750474 no 1098 0.309557461096125 1477 4302660
SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM 0.496468642385365 0.311895817916159 no 1099 0.309781902963835 1511 4213774
SGTC_1168 k815-0004 80.5 µM 0.495298507456085 0.312307899909736 no 1100 0.310194712167306 1448 642433
SGTC_442 cape 100 µM 0.494778452946139 0.312491120965412 no 1101 0.310378257841599 1596 5281787
SGTC_1415 3966-0071 78.1 µM 0.493005189870755 0.313116209832389 no 1102 0.31100446013785 1483 2893185
SGTC_13 0199-0087 65 µM 0.492510363034665 0.313290736089987 no 1103 0.311179298905448 1511 4589825
SGTC_2235 salicylic acid 500 µM 0.492216956900317 0.313394240682102 no 1104 0.311282989172135 1514 338 A COX inhibitor and kinase inhibitor.
SGTC_2342 7990637 118.86 µM 0.490834882672845 0.313881991216143 no 1105 0.311771618047181 1526 2033102 YER133W GLC7
SGTC_3211 9128781 49.47 µM 0.489895746954567 0.314213609191406 no 1106 0.312103836376619 1485 17194361
SGTC_2072 5231554 129 µM 0.489208699419089 0.314456307419397 no 1107 0.312346975607267 1570 789545
SGTC_2475 5812728 15.03 µM 0.48885921086262 0.314579794369288 no 1108 0.31247068747035 1468 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2
SGTC_813 k007-0158 173 µM 0.488318319136004 0.314770951877001 no 1109 0.312662193843849 1603 6523916
SGTC_1106 tegaserod maleate 11.7 µM 0.487205431458244 0.315164415605359 no 1110 0.313056378327252 1531 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation.
SGTC_2886 9058944 51.95 µM 0.48663604773797 0.315365803543824 no 1111 0.313258136564758 1431 4949929
SGTC_575 k072-0246 11.9 µM 0.486040433670423 0.3155765277315 no 1112 0.313469249226519 1512 6796779
SGTC_2176 5809774 33.9695 µM 0.485821071190079 0.315654151795276 no 1113 0.313547016651396 1536 2870539
SGTC_1934 st074720 32.6 µM 0.484762081016554 0.316029002619955 no 1114 0.313922561740198 1461 17250992
SGTC_1630 st005209 31.3 µM 0.48103807689133 0.317348689247002 no 1115 0.315244718414809 1540 3367314
SGTC_3086 9117350 49.47 µM 0.479913602567156 0.317747630488676 no 1116 0.315644414250879 1446 2679265
SGTC_1851 st056236 18.9 µM 0.4780929511208 0.318394010291642 no 1117 0.316292024432875 1582 5393171
SGTC_3142 9086498 49.47 µM 0.476369311612674 0.319006458176087 no 1118 0.316905646935298 1482 25236367
SGTC_3339 9145883 14.936 µM 0.47597618988466 0.319146212475064 no 1119 0.317045670471183 1559 2030670
SGTC_2915 7971052 15.16 µM 0.475204494654774 0.319420623943197 no 1120 0.317320611890113 1421 5741558
SGTC_1985 st071382 65.5 µM 0.474653196304162 0.319616723832679 no 1121 0.317517091544637 1512 6123237
SGTC_2696 st077691 74.316 µM 0.474472867951189 0.319680878582261 no 1122 0.317581370725806 1531 757133
SGTC_3269 9137823 49.47 µM 0.474004650478139 0.319847479766305 no 1123 0.317748295479357 1490 17682936
SGTC_45 0kpi-0036 14.9 µM 0.473427569697427 0.320052866707537 no 1124 0.317954082188007 1559 2795021
SGTC_2211 7117706 200 µM 0.473016708250144 0.320199128688425 no 1125 0.318100629439371 1573 822771
SGTC_838 0109-0203 71.4 µM 0.471990540406092 0.320564554723598 no 1126 0.318466770327018 1506 759422
SGTC_2989 9073649 71.4286 µM 0.470046971407094 0.321257150816355 no 1127 0.319160729591601 1564 21367202
SGTC_1901 st060216 58.6 µM 0.469853265347388 0.321326212625721 no 1128 0.319229927923899 1497 688792
SGTC_916 4466-0038 42 nM 0.469542605688215 0.321436984672716 no 1129 0.319340919172614 1575 5722064 YGL116W CDC20
SGTC_2086 5274770 176.623 µM 0.469298867673564 0.321523905559874 no 1130 0.319428012257584 1528 689278
SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM 0.468586813661094 0.321777891410326 no 1131 0.319682502253173 1550 5379071
SGTC_1698 5-fluorocytosine 1.055 µM 0.467565536255045 0.322142320990586 no 1132 0.320047657742738 1585 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_3069 9117009 49.47 µM 0.467202715138484 0.32227183019403 no 1133 0.320177425636619 1481 41904981
SGTC_366 0181-0206 4.31 µM 0.466852807104207 0.322396750505627 no 1134 0.320302595830055 1691 274874
SGTC_263 alizarin 107.927 µM 0.466727631942894 0.322441444034502 no 1135 0.320347378845978 1564 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium.
SGTC_417 st075190 100 µM 0.464925599555519 0.323085140058709 no 1136 0.320992368678993 1623 222757
SGTC_165 k038-0023 64.381 µM 0.464119951244341 0.323373093749578 no 1137 0.321280904156288 1484 46368543
SGTC_633 0437-0093 97.7 µM 0.46388650247794 0.323456552464388 no 1138 0.321364531839563 1531 2831118
SGTC_3181 9108277 49.47 µM 0.463502116269085 0.323593991172666 no 1139 0.321502249142565 1474 17097298
SGTC_318 1488-0629 67.2 µM 0.462970146963756 0.323784238460271 no 1140 0.321692882767451 1501 3662576
SGTC_2580 diallyl disulphide 81.36 µM 0.462523420508481 0.323944036067942 no 1141 0.321853005502904 1545 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.
SGTC_197 4544-0043 41.561 µM 0.46234089579803 0.324009335949019 no 1142 0.321918438408712 1524 896523
SGTC_3139 9095020 49.47 µM 0.461398725411419 0.324346492096152 no 1143 0.322256282902631 1407 25236292
SGTC_2534 helenine 20.12 µM 0.459565796566471 0.325002819161273 no 1144 0.322913957205495 1550 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58
SGTC_198 3454-2873 16.191 µM 0.458280337099098 0.325463435168447 no 1145 0.323375524434071 1545 710957
SGTC_1831 st055328 12 µM 0.458120814833293 0.3255206150652 no 1146 0.323432822741931 1628 1103068
SGTC_492 tmb-8 126 µM 0.456608121222349 0.326063035880977 no 1147 0.32397637043369 1535 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1
SGTC_2898 9056270 58.44 µM 0.454834274024297 0.326699570073343 no 1148 0.324614235319357 1532 19154699
SGTC_1140 3229-1848 2.98 µM 0.454666785497475 0.326759698413279 no 1149 0.324674489821626 1615 2849525
SGTC_1825 st052143 62.6 µM 0.452977252703976 0.327366491665118 no 1150 0.325282560714925 1600 674173
SGTC_500 h-89 112 µM 0.452876123586566 0.327402826533948 no 1151 0.325318972346218 1677 449241 Protein kinase A inhibitor; also known to inhibit several other kinases.
SGTC_3138 9097216 49.47 µM 0.452226762151655 0.327636175759406 no 1152 0.325552815245848 1526 25237486
SGTC_2827 7993847 71.43 µM 0.450323180401354 0.328320619124699 no 1153 0.326238713513585 1581 2985692
SGTC_18 0111-0177 500 nM 0.449106875754043 0.328758250304818 no 1154 0.326677280331186 1585 721752
SGTC_258 haloperidol 50.781 µM 0.448964576079299 0.328809465646806 no 1155 0.326728605443128 1507 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_2483 5729050 27.16 µM 0.448787030059035 0.328873371074851 no 1156 0.326792647920161 1688 2865180
SGTC_2195 6536160 144.242 µM 0.446927539435302 0.329542971330889 no 1157 0.327463689531431 1480 3834386
SGTC_2900 5328528 85.29 µM 0.445247106211839 0.330148563779916 no 1158 0.328070593961925 1501 795359
SGTC_2188 6126565 140.678 µM 0.438759867929234 0.332490592377966 no 1159 0.330417771175533 1609 874518
SGTC_1409 3909-8004 61.9 µM 0.438150322008593 0.332710989454239 no 1160 0.330638658848838 1582 2119279
SGTC_646 4092-0839 27.3 µM 0.433753907308375 0.334302335466464 no 1161 0.33223357802112 1652 877796
SGTC_130 0136-0219 337.655 µM 0.431266497224029 0.335204012735373 no 1162 0.333137303862034 1660 234244
SGTC_2019 4016004 108 µM 0.429739425560334 0.335758041952808 no 1163 0.333692600371798 1529 45595336
SGTC_1454 4239-0054 42.6 µM 0.427227087277417 0.336670307586989 no 1164 0.334606966881942 1660 1340767
SGTC_1514 1189-1591 158 µM 0.425903258182972 0.337151396062254 no 1165 0.335089170336165 1654 767698 YMR146C TIF34
SGTC_2955 9076254 12.21 µM 0.424651114068615 0.337606678952037 no 1166 0.335545512881361 1679 16459619
SGTC_3271 9137798 49.47 µM 0.423011484038824 0.338203212225025 no 1167 0.336143441149404 1689 6498326
SGTC_1010 4112-3296 15.2 µM 0.422675545476996 0.338325484234674 no 1168 0.336266000013216 1752 704384
SGTC_584 0986-0246 15.4 µM 0.422624319645301 0.338344130467971 no 1169 0.336284690018685 1649 53315 YDR232W HEM1
SGTC_1613 st002381 52.1 µM 0.422617921968791 0.338346459253885 no 1170 0.336287024271952 1574 551167
SGTC_456 gingerol 170 µM 0.421162063009254 0.338876559768838 no 1171 0.336818372268297 1641 442793 A herb.
SGTC_3 0833-0587 95.581 µM 0.418760131866293 0.339751837104304 no 1172 0.337695722217632 1584 5382644
SGTC_1871 st057448 67.3 µM 0.418303611969243 0.339918293487865 no 1173 0.33786257456618 1684 691747
SGTC_1709 st033179 39.1045 µM 0.416573321695259 0.340549475431559 no 1174 0.338495263185708 1581 573381
SGTC_641 4092-0595 30 µM 0.415145037481015 0.341070827194984 no 1175 0.33901786567719 1651 786260
SGTC_2158 5657123 3.6195 µM 0.414950072747862 0.341142016718527 no 1176 0.339089226421286 1617 2858827
SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM 0.414072290840398 0.341462600471242 no 1177 0.339410582518731 1625 616764
SGTC_1265 0819-1001 68.8 µM 0.414070994167631 0.341463074127123 no 1178 0.339411057317303 1577 3106768
SGTC_1186 1319-0216 26 µM 0.413989445489336 0.341492863186022 no 1179 0.339440918251477 1763 4565136
SGTC_1821 st053465 65.6 µM 0.413177008149064 0.341789693734454 no 1180 0.339738465994485 1570 675086
SGTC_2944 9067346 25.62 µM 0.412798997202112 0.341927836452689 no 1181 0.339876943108758 1640 6473075
SGTC_1377 2944-0135 198 µM 0.41169323971559 0.342332052935298 no 1182 0.340282140316253 1657 1894137
SGTC_86 0417-1630 471.922 µM 0.411064159756721 0.342562097673549 no 1183 0.340512744697049 1627 3634867
SGTC_822 1487-0950 154 µM 0.410658516871819 0.342710465936177 no 1184 0.340661474479685 1671 1958375
SGTC_89 0302-0250 142.109 µM 0.410114629109196 0.342909436832428 no 1185 0.340860930905152 1671 4203518 YLR208W SEC13
SGTC_1704 st028805 70.8 µM 0.409440871703981 0.343155978465988 no 1186 0.341108075275669 1599 2876101
SGTC_374 0880-0231 82.3 µM 0.407842634775647 0.343741073008875 no 1187 0.341694605217067 1647 6833587
SGTC_1047 2043-3044 82 µM 0.407603035354369 0.343828819671689 no 1188 0.3417825677499 1558 669592
SGTC_2501 sodium tetradecyl sulfate 13.37 µM 0.406417280608162 0.344263193321868 no 1189 0.34221801233811 1569 23665772 A membrane-active detergent.
SGTC_448 monastrol 171 µM 0.40579412126617 0.344491555668442 no 1190 0.34244693924869 1638 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity
SGTC_746 1095-0025 46.6 µM 0.404935199109119 0.34480640833171 no 1191 0.342762572039883 1710 6749286
SGTC_3140 9094243 49.47 µM 0.400773194134378 0.346333581931665 no 1192 0.344293558133679 1628 19291112
SGTC_1882 5615643 20 µM 0.399503247673998 0.346800065458418 no 1193 0.344761215607227 1592 2253075
SGTC_469 w7 172 µM 0.39940925431855 0.346834600843362 no 1194 0.344795838077852 1669 45115570 A P450 inhibitor.
SGTC_1145 3546-0597 10.2 µM 0.397732658448898 0.347450835434652 no 1195 0.3454136306228 1620 875334
SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM 0.396781894572516 0.347800469065006 no 1196 0.345764151582846 1595 2374 Ca(2+)-ATPase inhibitor.
SGTC_2189 6047310 154.431 µM 0.394167352758803 0.348762606698198 no 1197 0.346728743650399 1615 711535
SGTC_3153 9100258 49.47 µM 0.393105161898378 0.349153765774001 no 1198 0.347120905869763 1588 25236848
SGTC_3217 9129673 49.47 µM 0.392746529387852 0.349285870879323 no 1199 0.34725335045308 1640 17248312
SGTC_762 1165-0429 115 µM 0.388972131513582 0.350677304723872 no 1200 0.348648381013669 1751 5967793
SGTC_959 1222-0044 107 µM 0.388500097664238 0.350851461730423 no 1201 0.348822990901519 1771 6083612
SGTC_1238 0333-0287 48.8 µM 0.38628291207344 0.351669911722883 no 1202 0.349643577232382 1629 7226
SGTC_458 nppb 133 µM 0.383024241635646 0.352874062402317 no 1203 0.350850894994765 1788 4549 A chloride channel blocker.
SGTC_751 0833-0568 350 µM 0.382794403078431 0.35295904865609 no 1204 0.35093610584941 1688 6954252
SGTC_1971 st069429 63.5 µM 0.381541382063003 0.353422500892494 no 1205 0.351400785381047 1764 1246522 YGL099W LSG1
SGTC_270 tamoxifen 5.46 µM 0.377674013336633 0.35485428484347 no 1206 0.352836387406922 1790 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen. YIL048W NEO1
SGTC_1091 telmisartan 47.6 µM 0.375906524042323 0.35550933244137 no 1207 0.353493195081324 1734 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension.
SGTC_1379 2144-0755 36.5 µM 0.375339770108605 0.355719467111204 no 1208 0.353703896132799 1792 5392327
SGTC_2315 7733312 200 µM 0.374640601047172 0.355978757590565 no 1209 0.353963886662075 1621 726316
SGTC_2605 digitonin 300 nM 0.374012096921103 0.356211898483933 no 1210 0.354197658114217 1782 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_1730 st033808 45.1 µM 0.368118111816114 0.358400852256079 no 1211 0.356392583207678 1672 1045166
SGTC_324 1315-0088 19.6 µM 0.367915576388862 0.358476154672027 no 1212 0.356468092678307 1710 6787421
SGTC_2914 7968218 45.32 µM 0.367167569104968 0.358754310509604 no 1213 0.356747014283827 1765 2977111
SGTC_158 k038-0087 26.446 µM 0.367060029243593 0.358794306712197 no 1214 0.356787120718132 1698 X158
SGTC_1011 4112-3381 17.4 µM 0.364044548600231 0.359916452611602 no 1215 0.357912371733362 1727 2877139
SGTC_219 mitoxanthrone 164.414 µM 0.363984681761355 0.359938743025995 no 1216 0.357934724070609 1752 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA. YMR168C CEP3
SGTC_3351 9150312 21.596 µM 0.363050050766109 0.360286798938774 no 1217 0.358283748106758 1686 4904905
SGTC_12 0849-0099 9.267 µM 0.362249739178622 0.360584926467749 no 1218 0.35858270670807 1760 6071388
SGTC_1076 itraconazole 331 nM 0.35836279278605 0.362034072231842 no 1219 0.360035916088936 1690 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1
SGTC_1059 3448-6867 171 µM 0.354515314647793 0.363470453811427 no 1220 0.361476364459408 1823 3934407
SGTC_783 0848-0141 92.7 µM 0.354419812969014 0.363506132039743 no 1221 0.361512144194196 1670 6755076 YHR007C | YLR033W ERG11 | RSC58
SGTC_2117 5521686 200 µM 0.354075163381554 0.36363489864294 no 1222 0.361641277343007 1652 803312
SGTC_565 1418-0001 44.5 µM 0.35400612146511 0.36366069566082 no 1223 0.361667147831619 1765 2862145
SGTC_1757 st041620 31.8375 µM 0.352275412028031 0.36430756453185 no 1224 0.362315863062907 1674 5289815
SGTC_3096 9117468 49.47 µM 0.351576778641425 0.364568794967699 no 1225 0.362577841338477 1746 41316311
SGTC_236 1509-0011 5.31 µM 0.349964257181019 0.365171983059693 no 1226 0.363182761056065 1757 3107280
SGTC_3261 9137475 49.47 µM 0.349208792011961 0.365454691151237 no 1227 0.36346628306535 1717 17027690
SGTC_3193 9111931 49.47 µM 0.347816779093241 0.365975797764064 no 1228 0.363988893822383 1705 17087244
SGTC_2648 atorvastatin 78.68 µM 0.34780641970764 0.365979676777374 no 1229 0.363992784051063 1787 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11
SGTC_3293 9120939 62.045 µM 0.347293229285127 0.366171855168188 no 1230 0.364185518434075 1761 934087
SGTC_2185 6113692 200 µM 0.347206237410967 0.366204435018075 no 1231 0.36421819260846 1726 874150
SGTC_2452 5863136 48.41 µM 0.345274030983345 0.366928325507053 no 1232 0.364944183936772 1665 2184096
SGTC_2670 beta-carotene 100 µM 0.343849324062232 0.367462387505715 no 1233 0.36547980204346 1753 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.)
SGTC_355 1311-2252 105 µM 0.343597285130596 0.367556892902097 no 1234 0.365574583347553 1663 5338538
SGTC_2943 9068529 45.32 µM 0.342182495612071 0.368087536047961 no 1235 0.366106778741409 1711 3270634
SGTC_2089 5281248 129.67 µM 0.342029379560931 0.368144980190993 no 1236 0.366164391230444 1680 2737878
SGTC_685 1278-0033 54.9 µM 0.341919858144812 0.368186070859062 no 1237 0.366205602355993 1791 3590572
SGTC_3115 9123671 49.47 µM 0.341883375051896 0.368199759061679 no 1238 0.366219330692495 1761 3286988
SGTC_2877 9040724 71.43 µM 0.341426171174739 0.36837131295696 no 1239 0.366391387875211 1844 6463895
SGTC_2779 methotrexate 400 µM 0.339079307537556 0.369252325103051 no 1240 0.367274993108143 1759 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2
SGTC_2673 kobusone 100 µM 0.336550071506239 0.37020256913467 no 1241 0.368228049829534 1771 6710676 An epoxy ketone and protein crosslinker.
SGTC_2803 7707263 71.43 µM 0.336304182451569 0.370294993003954 no 1242 0.368320748144545 1686 2199229
SGTC_1020 4335-0961 93.3 µM 0.335863190326232 0.370460770250753 no 1243 0.368487018042012 1638 669075
SGTC_1638 st008370 60.6 µM 0.33489817611987 0.370823621159317 no 1244 0.36885094899275 1692 24207134
SGTC_416 estradiol valerate 100 µM 0.334560113640652 0.370950761796222 no 1245 0.368978468632566 1754 13791 A steroid.
SGTC_2760 etidronate 98.04 µM 0.331988233040937 0.371918471028331 no 1246 0.369949072135151 1691 3305 A chelator and antioxidant.
SGTC_108 0509-0257 621.132 µM 0.331610837123709 0.372060540257402 no 1247 0.370091567690757 1821 536624
SGTC_2096 5468907 200 µM 0.33065636967337 0.372419923522378 no 1248 0.370452031024703 1852 759785
SGTC_2953 9074162 66.49 µM 0.325856400212212 0.374228922890623 no 1249 0.372266502158205 1899 16451992
SGTC_1330 1469-0054 61.8 µM 0.324772410294627 0.374637839267755 no 1250 0.372676663489277 1892 7102664
SGTC_2630 antimycin a 100 µM 0.323305559891089 0.375191407567186 no 1251 0.373231921868276 1687 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain.
SGTC_900 1112-0045 141 µM 0.322948164396169 0.375326322503515 no 1252 0.373367249531813 1771 56211 YIL048W NEO1
SGTC_1510 1123-0200 71.5 µM 0.321682920239109 0.37580406804199 no 1253 0.373846459162815 1850 5378812 YNL149C | YNL150W PGA2 | YNL150W
SGTC_115 0527-0192 112.043 µM 0.320102292875465 0.376401167138619 no 1254 0.37444539378891 1748 4233931
SGTC_1736 st036774 51 µM 0.319214126682063 0.37673681147431 no 1255 0.374782072680431 1940 1272247
SGTC_53 0973-0023 39.979 µM 0.319069578906466 0.376791445933477 no 1256 0.374836875726894 1933 674768
SGTC_2071 5230951 39.92 µM 0.318690245722402 0.376934833537093 no 1257 0.374980706035851 1830 1799272
SGTC_2682 pyrogallin 40.03 µM 0.317727482122588 0.377298833487133 no 1258 0.375345831448238 1803 822798 An ATP competetive kinase inhibitor.
SGTC_1004 4084-0029 199 µM 0.316779569103033 0.377657325292416 no 1259 0.375705433957281 1881 716894 YLR208W SEC13
SGTC_1678 st019265 80.2 µM 0.314172434429257 0.378643861983512 no 1260 0.376695038814219 1910 5367020
SGTC_1739 st037196 92.5 µM 0.312419729842299 0.379307528589734 no 1261 0.377360779001989 1894 612214
SGTC_2836 9010338 19.48 µM 0.312206396986303 0.379388332016233 no 1262 0.377441835416725 1615 2994051
SGTC_2766 oltipraz 83.91 µM 0.312008597639309 0.379463256570982 no 1263 0.377516994654883 1841 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40
SGTC_660 4031-1742 102 µM 0.310906340145009 0.379880864296606 no 1264 0.377935912223487 1752 6738706
SGTC_477 mead ethanolamide 10 µM 0.309648204287135 0.380357700231917 no 1265 0.378414247470826 1761 16061185
SGTC_2009 4012297 12.05 µM 0.307761691079042 0.381073033013484 no 1266 0.379131836843454 1738 45595307
SGTC_624 k048-0052 28 µM 0.307520594022162 0.381164482149484 no 1267 0.379223575101988 1772 6835531
SGTC_1300 1094-0077 113 µM 0.307106890071702 0.381321417274191 no 1268 0.379381006723494 1741 5532636
SGTC_159 3970-0959 50 µM 0.306395078014895 0.381591482875442 no 1269 0.379651927726341 1847 6615653
SGTC_913 3487-1245 167 µM 0.305689330822304 0.38185930435307 no 1270 0.379920598736824 1675 4016153
SGTC_1291 0993-0025 5.79 µM 0.304506706774212 0.382308220853701 no 1271 0.380370941969596 1859 4353356
SGTC_1500 4488-1866 171 µM 0.302193138755238 0.383186893504246 no 1272 0.381252417185202 1869 2900003
SGTC_125 0133-0007 11.75 µM 0.301500222868151 0.383450174044732 no 1273 0.381516540040539 1947 26541
SGTC_1837 st055472 66.5 µM 0.301363062336655 0.383502295989772 no 1274 0.381568828879865 1828 676091
SGTC_2179 6298986 200 µM 0.301273138253278 0.383536468904027 no 1275 0.381603111240821 1915 738374
SGTC_1924 st058459 75.1 µM 0.300578595193402 0.383800439382716 no 1276 0.381867927817119 1808 688683
SGTC_1346 1488-2224 62.4 µM 0.300476528259089 0.383839235848594 no 1277 0.381906848736352 1907 3722427
SGTC_2707 st078556 66.6 µM 0.300146544923737 0.38396467314394 no 1278 0.382032688591468 1917 17250899
SGTC_767 0929-0023 86 µM 0.30003754829699 0.384006108944482 no 1279 0.382074257428744 1768 1204563
SGTC_1875 nocodazole 6 µM 0.299010361528168 0.38439666596947 no 1280 0.382466069838623 1911 4122 A microtubule depolymerizer. YJL014W CCT3
SGTC_3305 9127027 53.8275 µM 0.298818301187861 0.384469704203329 no 1281 0.382539343130247 1793 41905295
SGTC_343 4130-2827 29.8 µM 0.298130568667023 0.384731274218502 no 1282 0.382801755694813 1732 1118244
SGTC_38 0929-0051 58.268 µM 0.297460968476227 0.384985998263551 no 1283 0.383057301352744 1936 1379719
SGTC_1888 azatryptophan 97.5 µM 0.296370877846923 0.385400788129426 no 1284 0.383473431475673 1768 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides
SGTC_1556 plumbagin 1.48 µM 0.295225151397493 0.385836889283271 no 1285 0.383910944883861 1842 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_2407 paclitaxel 400 µM 0.295025297242136 0.385912975144224 no 1286 0.383987277467506 1854 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_1549 4'-methoxyflavonol 74.6 µM 0.293931206781484 0.386329580667619 no 1287 0.384405235642767 1820 97141
SGTC_2230 bromochlorosalicylanilide 954.5 nM 0.293671955764224 0.386428316965962 no 1288 0.384504292950695 1903 77254
SGTC_309 k408-0051 1.48 µM 0.291820504348941 0.387133659587782 no 1289 0.385211933536676 1804 3640463
SGTC_2729 fluphenazine 10.66 µM 0.291541983063922 0.387239799435126 no 1290 0.385318419904327 1753 3372 An atypical antipsychotic.
SGTC_2289 7946404 165.07 µM 0.291499781312072 0.387255882559257 no 1291 0.385334555552355 1754 1246120 YPR165W RHO1
SGTC_1236 0330-0013 258 µM 0.290982463442206 0.38745304856542 no 1292 0.385532365811048 1783 4617066
SGTC_32 0928-0142 34.1 µM 0.290969755364487 0.387457892376514 no 1293 0.385537225457802 1877 2244242
SGTC_1883 5-benzylidenerhodanine 20 µM 0.290029471772663 0.387816339440364 no 1294 0.385896845466833 1917 1273210
SGTC_1063 disulfiram 1.84 µM 0.289941317767855 0.387849949681568 no 1295 0.385930565800944 1808 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_3173 9105693 49.47 µM 0.288848409539092 0.388266709581381 no 1296 0.386348692397642 1858 17096658
SGTC_2121 5257820 149.641 µM 0.287802336908641 0.38866573015783 no 1297 0.386749024213614 1931 791256
SGTC_1531 st059297 52.4 µM 0.286049439017802 0.389334629864424 no 1298 0.38742012796812 1831 7566702
SGTC_616 4092-0450 108 µM 0.285940342035381 0.389376271755503 no 1299 0.387461907316572 1833 787165
SGTC_1775 st081588 35.1725 µM 0.284914708403177 0.389767814144647 no 1300 0.387854743570667 1767 1426443 YGL099W LSG1
SGTC_453 enantio-paf c16 10 µM 0.28464849111548 0.389869462653479 no 1301 0.387956728395969 1834 13871343 A lipid and platelet activating factor
SGTC_578 3460-0051 92 µM 0.284242633353658 0.39002444392813 no 1302 0.388112222774405 1944 2876744
SGTC_350 k064-0020 19.8 µM 0.284195203420275 0.390042556714147 no 1303 0.388130395553226 1932 2790705
SGTC_1620 st003704 16.5 µM 0.284008859908387 0.390113720840558 no 1304 0.388201795440588 1927 2834414
SGTC_2236 dapsone 200 µM 0.283916297906376 0.390149071409408 no 1305 0.388237263154143 1914 2955 A bacterial DFR inhibitor. An anti-cancer agent.
SGTC_3151 9099821 49.47 µM 0.283255006944023 0.390401652986209 no 1306 0.388490682337027 1761 17174189
SGTC_3009 9080819 71.4286 µM 0.282951190029489 0.390517712059744 no 1307 0.388607126636927 1779 17027216
SGTC_489 paxilline 115 µM 0.281508307066956 0.391069031176671 no 1308 0.389160278743013 1781 105008 A toxic potassium channel blocker.
SGTC_3344 9148862 3.898 µM 0.280362435742253 0.391507019540107 no 1309 0.389599726870434 1906 4905352
SGTC_31 0508-1974 57.237 µM 0.280287649818444 0.391535609880684 no 1310 0.389628412608985 1892 6810525
SGTC_2786 7743617 45.45 µM 0.279491077959177 0.391840172241857 no 1311 0.389933992043163 1728 583674
SGTC_2837 9008476 45.46 µM 0.279044826318723 0.392010821681598 no 1312 0.390105212025092 1857 2992805
SGTC_921 1561-0023 372 µM 0.278872431997764 0.392076751921276 no 1313 0.390171362821101 1740 24050882
SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM 0.277015652314852 0.392787052158889 no 1314 0.390884043740495 1766 6708514
SGTC_2284 7945075 39.21 µM 0.275926282325265 0.393203950708173 no 1315 0.391302343431669 1961 1245402
SGTC_252 miconazole 1.30953 nM 0.274717231793895 0.393666794047232 no 1316 0.391766745647545 1872 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_56 0957-0365 83.25 µM 0.274052520943127 0.393921319756517 no 1317 0.392022130097021 1909 6752360
SGTC_1705 st027868 56.3335 µM 0.271550341821894 0.394879839512252 no 1318 0.392983893227795 1927 292948
SGTC_885 0865-0106 16.8 µM 0.271333106610291 0.394963086789018 no 1319 0.393067422893872 1758 2793380
SGTC_2982 9019404 25.97 µM 0.27109999754341 0.395052422461168 no 1320 0.393157061732947 1608 22333232
SGTC_1811 st050069 61.5 µM 0.269438604501587 0.395689286791868 no 1321 0.393796091044247 1982 3877702
SGTC_11 0438-0307 1.3 µM 0.26914972427449 0.395800052171663 no 1322 0.393907233632208 1964 4011476
SGTC_2070 5230947 200 µM 0.268254479983456 0.396143369209326 no 1323 0.394251721081414 1945 2835538
SGTC_2048 5246248 200 µM 0.268203376865132 0.396162969166206 no 1324 0.394271387914298 1975 677046
SGTC_339 3091-4833 71.4 µM 0.268186958300091 0.396169266355586 no 1325 0.394277706591306 1870 3240077
SGTC_590 k048-0076 22.4 µM 0.267584456238737 0.396400369197038 no 1326 0.39450959845619 1941 6832814
SGTC_1938 st074717 56.4 µM 0.267504434637262 0.396431065972648 no 1327 0.394540400100279 1806 17250979
SGTC_425 3825-7017 13.1 µM 0.266355803477859 0.396871758567181 no 1328 0.394982599887717 1881 3397440
SGTC_848 0368-0089 85.6 µM 0.265929171057647 0.397035477199274 no 1329 0.395146879240257 1924 762535
SGTC_1359 1582-0056 520 nM 0.259967050691275 0.39932530550906 no 1330 0.397444594853073 1895 3661189
SGTC_2058 5236698 133 µM 0.257823164009636 0.400149544384161 no 1331 0.39827169320731 1830 766665
SGTC_738 1315-0003 72.4 µM 0.255251950574172 0.401138659947196 no 1332 0.399264254404846 1940 6251474
SGTC_1055 3448-0672 86 µM 0.255220829001234 0.401150635946048 no 1333 0.399276272217076 1870 748378
SGTC_1646 st011709 75.6 µM 0.253408210431912 0.401848315775731 no 1334 0.399976391835163 1960 5757843
SGTC_2449 5812982 45.77 µM 0.250444252531629 0.40298982122914 no 1335 0.401121905571701 1880 776185
SGTC_1874 staurosporine 7.6 µM 0.248959270937987 0.403562042059198 no 1336 0.401696143346319 1945 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1
SGTC_2390 9097792 176.6 µM 0.247131674680018 0.404266568925999 no 1337 0.40240316049423 1791 4497149
SGTC_1366 1683-0113 21.9 µM 0.246383215091267 0.404555185165768 no 1338 0.402692799123311 1832 708623
SGTC_1321 1326-2144 215 µM 0.245871396946487 0.404752579147108 no 1339 0.402890893091937 1966 3513030
SGTC_895 0964-0006 13.7 µM 0.245865797332546 0.404754738896153 no 1340 0.402893060503092 1974 6738897
SGTC_281 1672-3440 14.9 µM 0.245503067008235 0.404894648732679 no 1341 0.4030334668493 1962 6833000
SGTC_1813 st051246 8.6015 µM 0.244788491923969 0.405170305253277 no 1342 0.403310102499602 1982 5291959
SGTC_996 3970-0799 1.8 µM 0.242790618993348 0.40594125967799 no 1343 0.404083801566548 1994 6615648 YGL040C HEM2
SGTC_3272 9137413 49.47 µM 0.242333728714492 0.406117619355184 no 1344 0.404260790379436 1814 17614870
SGTC_3314 9135860 59.4275 µM 0.241961188770019 0.406261433899778 no 1345 0.404405118313603 2008 25252478
SGTC_1948 st076329 66.6 µM 0.241263395706479 0.40653084249836 no 1346 0.404675489501821 1973 24208413
SGTC_605 1315-0399 119 µM 0.240615588176506 0.406780991960793 no 1347 0.404926533737539 1934 24020461
SGTC_2716 st080858 38.6235 µM 0.240130128954619 0.406968475918607 no 1348 0.405114688945066 1973 5296050
SGTC_3122 9126309 49.47 µM 0.24005302996357 0.406998253449456 no 1349 0.40514457313804 2026 17591206
SGTC_1716 st033144 30.6155 µM 0.238235811091467 0.407700263480181 no 1350 0.405849101669382 1998 674617
SGTC_902 1120-0002 2.07 µM 0.237720648376001 0.407899330082925 no 1351 0.406048883802938 1847 3280475
SGTC_1796 st049173 110.4 µM 0.236681738445041 0.408300852747137 no 1352 0.406451851547492 1993 94134
SGTC_79 0052-0007 94.094 µM 0.234398059901937 0.4091837972064 no 1353 0.407337982336784 1971 2801472
SGTC_3218 9131285 49.47 µM 0.234230520955931 0.4092485914195 no 1354 0.407403010841642 1996 17156417
SGTC_2136 5328288 199.296 µM 0.231760758467732 0.410204037101098 no 1355 0.408361918718645 1857 262395
SGTC_2396 5342950 42.78 µM 0.231228296393091 0.410410094022862 no 1356 0.408568724122106 1877 1886677
SGTC_2816 7982706 58.44 µM 0.231041777422148 0.410482280650055 no 1357 0.408641173111349 1869 2981853
SGTC_3328 9140624 29.0385 µM 0.229918766549476 0.410916972666163 no 1358 0.409077446670416 2002 4904392
SGTC_2016 5121758 140 µM 0.22904526741832 0.411255160035204 no 1359 0.409416866431105 1958 2795203
SGTC_1082 camptothecin 424.86 nM 0.229042575983738 0.411256202163688 no 1360 0.40941791235987 1661 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_2801 7907800 81.82 µM 0.228222771143663 0.411573661236644 no 1361 0.409736529853113 1881 6620925
SGTC_1376 2910-0861 41.3 µM 0.227150407805914 0.411989007768938 no 1362 0.410153394277901 1930 1112859
SGTC_1314 1222-0010 41.1 µM 0.226251080166767 0.412337410364576 no 1363 0.41050307210539 1917 3526027
SGTC_3089 9117425 49.47 µM 0.225568441720764 0.412601912969593 no 1364 0.410768544058235 1839 9401657
SGTC_1696 st025591 34.7925 µM 0.225410593087307 0.412663080392931 no 1365 0.410829935796019 1900 2787147
SGTC_2998 9066762 71.4286 µM 0.225119172454383 0.412776013449464 no 1366 0.410943283149353 1975 4945196
SGTC_1460 k062-0059 9.15 µM 0.224713458475518 0.412933250163873 no 1367 0.411101097005302 1839 1373085
SGTC_841 0251-0215 91.2 µM 0.224077492200517 0.41317975054128 no 1368 0.411348502908673 1971 3888614
SGTC_1827 berberine 7.24 µM 0.223364585638196 0.413456113644722 no 1369 0.411625882312587 1773 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_2466 5983409 37.09 µM 0.222940938610354 0.413620363633325 no 1370 0.411790736852548 1896 2879657
SGTC_76 0433-0009 400.328 µM 0.222077193480789 0.413955288566253 no 1371 0.412126895774913 1864 2841569
SGTC_3032 9089427 49.47 µM 0.220239252546138 0.414668174691532 no 1372 0.412842413963773 1904 17173707
SGTC_1399 3562-5772 25 µM 0.220017092553492 0.414754363459609 no 1373 0.412928921459722 1923 23847490
SGTC_612 0302-0167 22.4 µM 0.218816327123576 0.415220281063269 no 1374 0.413396563931154 1995 235821
SGTC_670 4204-0025 119 µM 0.218369975900483 0.415393503438879 no 1375 0.413570428405695 1979 719039
SGTC_234 nsc-17383 10.7 µM 0.217749370758595 0.415634378531361 no 1376 0.413812197104315 2001 408974
SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM 0.217020927472636 0.415917149216741 no 1377 0.414096017908085 1896 6857784
SGTC_387 norethindrone acetate 66.7 µM 0.21629644860609 0.416198424157865 no 1378 0.414378338575677 1879 541197
SGTC_3345 9148410 3.559 µM 0.216060319598904 0.416290109230259 no 1379 0.414470364766004 2019 4903596
SGTC_3148 9097893 49.47 µM 0.215775719677794 0.416400620827437 no 1380 0.414581287689415 1823 17174100
SGTC_3133 9127736 49.47 µM 0.215705210045414 0.416428001098193 no 1381 0.414608769897663 2083 27243420
SGTC_1631 benzylvanillin 81.9 µM 0.211882267130374 0.417913128292884 no 1382 0.41609944264594 1932 75506
SGTC_516 3992-2719 87.3 µM 0.211554052149067 0.418040687318484 no 1383 0.41622747948113 1809 5350887 YDR037W KRS1
SGTC_402 epigallocatechin gallate 10 µM 0.211328379633202 0.418128398757496 no 1384 0.41631551960595 1897 65064 An antioxidant.
SGTC_699 0375-0592 111 µM 0.209887204093518 0.41868863185457 no 1385 0.416877854725123 2099 762578
SGTC_3061 glucosamine 200 µM 0.208001685859666 0.419421844730564 no 1386 0.417613825508766 2054 91431 and experimental redox chemotherapeutic
SGTC_1389 3405-0187 19 µM 0.206485134144459 0.4200117824914 no 1387 0.41820598788877 1880 799890
SGTC_2785 7756463 72.73 µM 0.205856261207355 0.420256466514397 no 1388 0.418451596068605 1908 2201551
SGTC_2788 5282734 71.43 µM 0.203844236586521 0.421039518505234 no 1389 0.419237611371129 2034 743706
SGTC_2614 arthonioic acid 13.39 µM 0.202755786935655 0.421463258406546 no 1390 0.419662958494388 1992 6710684
SGTC_1539 benzyladenosine 56 µM 0.20240143998554 0.421601227426687 no 1391 0.41980145137665 1943 92208 A nucleotide analog.
SGTC_1526 st051518 75 µM 0.202353246669875 0.42161999278686 no 1392 0.419820288009024 1892 673993
SGTC_2739 tacrine 100.86 µM 0.202110302002956 0.421714592519049 no 1393 0.419915247114326 1970 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders.
SGTC_1588 farnesol 29.9 µM 0.200833200418172 0.422211954696042 no 1394 0.42041450080802 1903 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM 0.200479875973721 0.422349577452843 no 1395 0.420552647579241 2082 551469
SGTC_2757 clomiphene 4.22 µM 0.200075058891001 0.422507268665648 no 1396 0.420710939550286 2074 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined.
SGTC_278 4092-0821 23.9 µM 0.19824603569033 0.423219895265166 no 1397 0.421426285452008 2014 877900
SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM 0.197490989716864 0.423514150749114 no 1398 0.421721665879191 1916 279621
SGTC_2854 9024559 71.43 µM 0.197343355124432 0.423571691691937 no 1399 0.421779426944996 1899 3163529
SGTC_2405 ticlatone 3.52 µM 0.197225861539387 0.423617486268309 no 1400 0.421825396742031 1868 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W
SGTC_1494 4358-1428 177 µM 0.197222536938408 0.423618782087628 no 1401 0.421826697519885 2104 1564571
SGTC_3030 9087619 49.47 µM 0.196207416166529 0.42401448110036 no 1402 0.422223911808943 1942 25236973
SGTC_2372 9071633 200 µM 0.195162830786818 0.424421745546361 no 1403 0.422632738124347 2102 21321366
SGTC_161 4065-0411 162.148 µM 0.195116728072381 0.424439722001572 no 1404 0.422650783573522 1968 1906281 YLR208W SEC13
SGTC_795 0685-0265 78 µM 0.19381059860449 0.424949075572936 no 1405 0.423162093940851 2063 302754
SGTC_1672 st016598 6.51 µM 0.192761783502483 0.425358174578685 no 1406 0.423572767228786 1919 4665860 YNL267W PIK1
SGTC_321 4534-3890 65.3 µM 0.191432282463387 0.425876872927886 no 1407 0.424093464986088 2070 699746
SGTC_182 3448-4371 550.524 µM 0.190978636604726 0.426053890046618 no 1408 0.424271165307039 2141 3491403
SGTC_1028 k015-0029 4.8 µM 0.190931493673541 0.426072286541816 no 1409 0.424289632829086 1944 4588309
SGTC_1328 1441-0025 69.2 µM 0.189832627746177 0.426501140373773 no 1410 0.424720143756073 1979 4562601
SGTC_1166 k206-0078 225 µM 0.188689695723475 0.426947284065193 no 1411 0.425168014068792 1951 5404595
SGTC_468 gf-109203x 121 µM 0.18852461492051 0.427011731120411 no 1412 0.425232710769412 2082 2396 A protein kinase C inhibitor.
SGTC_1917 st066507 28.5 µM 0.188215417840405 0.427132445982858 no 1413 0.425353893394342 1930 3156428
SGTC_2849 9019321 12.99 µM 0.187503912878773 0.427410253365905 no 1414 0.4256327780318 1986 16489627
SGTC_205 1486-1330 71.903 µM 0.187239162628812 0.427513634398637 no 1415 0.425736560218684 1984 4118834
SGTC_3190 9110366 49.47 µM 0.187060160539403 0.427583534871453 no 1416 0.425806732013429 2089 17123768
SGTC_2737 bleomycin 30.5 nM 0.185655114586006 0.428132285326454 no 1417 0.426357614818266 2034 16211318 Bleomycin acts by induction of DNA strand breaks.
SGTC_3157 9099274 49.47 µM 0.182823774970469 0.429238505931259 no 1418 0.427468146640421 2089 17217662
SGTC_359 0081-0058 15.9 µM 0.182612076054054 0.429321240356326 no 1419 0.42755120417908 2062 3494159
SGTC_2515 chrysin 20.77 µM 0.181988186398252 0.429565081812249 no 1420 0.427795998487702 2057 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor.
SGTC_890 0929-0006 47.2 µM 0.180930881953853 0.429978380714428 no 1421 0.428210914289223 1919 1378169
SGTC_2068 5226020 147 µM 0.180610871067262 0.430103487693564 no 1422 0.428336511170557 1948 1810509
SGTC_1983 st071813 46.9 µM 0.18050245649347 0.430145873530663 no 1423 0.428379063033497 1977 11838595
SGTC_2323 6148992 148.28 µM 0.17990562393006 0.430379226005157 no 1424 0.42861332999241 1958 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42
SGTC_1284 0929-0043 16 µM 0.177667349960371 0.431254573097198 no 1425 0.429492114102824 1974 1239883
SGTC_2573 2',4'-dihydroxychalcone 15.04 µM 0.177421347540411 0.431350800721695 no 1426 0.429588720198319 2022 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM 0.176237150359465 0.431814074551914 no 1427 0.430053817882992 2003 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1
SGTC_784 4579-0127 173 µM 0.175423708500466 0.432132358304716 no 1428 0.430373356369153 2085 1948547
SGTC_2383 9036125 200 µM 0.174591628713906 0.432457980289281 no 1429 0.430700263435695 1997 79580
SGTC_981 1488-1094 54.9 µM 0.174556926067402 0.4324715616493 no 1430 0.430713898426334 2026 3449522
SGTC_1230 0170-0365 3.77 µM 0.174047684634709 0.432670869485259 no 1431 0.43091399358387 2099 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1
SGTC_967 1306-0166 352 µM 0.173270176005175 0.432975205252191 no 1432 0.431219532597118 2097 4437607
SGTC_47 0149-0135 24.25 µM 0.173144718156977 0.433024316231806 no 1433 0.431268837862958 1921 5239155
SGTC_2687 chenodiol 100 µM 0.172041271817263 0.433456309218877 no 1434 0.431702541242766 2007 5702181 A cholesterol synthesis inhibitor.
SGTC_2238 6671620 73.2395 µM 0.172036390540048 0.433458220388261 no 1435 0.43170445998464 2120 729941
SGTC_1517 deoxycholic acid methyl ester 49.2 µM 0.171109472267261 0.433821165404542 no 1436 0.432068843962261 2076 229346 A bile salt which induces apoptosis.
SGTC_1766 st045414 44.774 µM 0.170244683767502 0.434159833153763 no 1437 0.432408856017018 2054 253960
SGTC_2963 9082507 9 µM 0.170062318085474 0.434231257228644 no 1438 0.432480563798615 2042 16459611
SGTC_1847 st056231 15 µM 0.168683672709619 0.434771277195193 no 1439 0.43302273101352 2102 5393180
SGTC_3044 9093193 49.47 µM 0.1684017154816 0.434881735800845 no 1440 0.433133629309566 1948 25236277
SGTC_2177 5811945 192 µM 0.168214502662528 0.434955080466984 no 1441 0.433207266020794 2071 5343475
SGTC_3083 9117465 49.47 µM 0.167365130454511 0.435287868454368 no 1442 0.433541380011439 1951 16420915
SGTC_1745 st081495 74 µM 0.167106174560746 0.435389337708645 no 1443 0.433643253866741 2004 13842402 YBL026W LSM2
SGTC_1086 cerivastatin 2.18 µM 0.16708983608156 0.435395739919617 no 1444 0.43364968161065 2130 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7
SGTC_2069 5228469 200 µM 0.16120533462275 0.437702662373125 no 1445 0.435965839825508 2016 2835210
SGTC_2107 5363541 170.161 µM 0.160699722499311 0.437900979305553 no 1446 0.436164954003523 2125 244052
SGTC_541 4513-1321 94 µM 0.160669764757738 0.437912730161345 no 1447 0.436176752114686 1943 747515
SGTC_780 0109-0199 192 µM 0.160499199989049 0.437979634845735 no 1448 0.436243925886922 2140 610414
SGTC_2091 4-phenylthiadiazole 200 µM 0.160039672069295 0.43815989525123 no 1449 0.43642491158523 2030 270010
SGTC_1486 3970-0793 4.53 µM 0.158801698444442 0.438645582651891 no 1450 0.436912555314127 2143 2844330
SGTC_2191 5911152 200 µM 0.158538677690685 0.43874878406811 no 1451 0.43701617281992 2063 2875902
SGTC_1850 st056238 17 µM 0.1582942752811 0.438844683940108 no 1452 0.437112459468079 2132 5393177
SGTC_1431 4049-0260 9.09 µM 0.158219355998239 0.438874081872092 no 1453 0.43714197598972 2055 3854841
SGTC_288 1315-0019 35.1 µM 0.157717526133033 0.439071005954146 no 1454 0.437339694744533 2047 6811474
SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM 0.157591672858905 0.439120394661674 no 1455 0.43738928283618 2000 6708784 An antioxidant flavonoid
SGTC_2317 5986382 200 µM 0.155507255922541 0.439938521444959 no 1456 0.43821071706428 2086 877883
SGTC_66 0109-0187 42.4 µM 0.155443567224232 0.439963523105897 no 1457 0.438235819937013 2106 759417
SGTC_2730 imipramine 71.33 µM 0.155112613429432 0.440093446312449 no 1458 0.438366269230103 2146 3696 A tricyclic antidepressant.
SGTC_3196 9111891 49.47 µM 0.154799564856428 0.440216346366668 no 1459 0.438489667134835 2137 18891510
SGTC_362 0310-0100 9.03 µM 0.153092248223767 0.440886724590219 no 1460 0.439162764419855 2028 790235
SGTC_2472 5377652 49.4 µM 0.152625134238638 0.441070166592167 no 1461 0.439346951480581 1988 1610903
SGTC_133 0724-0033 378.92 µM 0.151104801974818 0.441667309056539 no 1462 0.439946522284837 2149 280309
SGTC_2611 pyromycin 23.93 µM 0.150436595428874 0.441929803257062 no 1463 0.440210085401989 2007 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release.
SGTC_1664 st014217 9.02 µM 0.149078761105416 0.442463285090102 no 1464 0.440745742391284 2174 3982782
SGTC_2656 pseudo-anisatin 100 µM 0.147575741596265 0.443053930625769 no 1465 0.441338800424393 2064 6708809 A neurotoxin.
SGTC_2977 9011197 71.43 µM 0.1474682522692 0.443096175854628 no 1466 0.441381218375851 2121 2704722
SGTC_3074 9116018 49.47 µM 0.147216288131531 0.443195204803652 no 1467 0.441480652301372 2058 17027303
SGTC_1763 st044482 94.5 µM 0.146766578724026 0.443371961985194 no 1468 0.441658132639358 2089 88505
SGTC_1332 1480-0653 17.5 µM 0.145977600623806 0.443682095101483 no 1469 0.441969535551517 2178 5749438
SGTC_2517 totarol 10 µM 0.145322916274875 0.443939465953738 no 1470 0.44222796110543 1993 460178 An antibacterial membrane disruptor. YGL001C ERG26
SGTC_1209 2323-2347 50.3 µM 0.144623360660905 0.444214502818932 no 1471 0.442504126001724 2178 5412760
SGTC_1537 2',6'-dihydroxyflavanone 78 µM 0.143041815984265 0.444836400803477 no 1472 0.443128578179543 2085 5106787 A p450 inhibitor.
SGTC_2725 haloperidol 53.21 µM 0.142251794601218 0.445147105462832 no 1473 0.443440560773618 2143 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_405 ebelactone b 50 µM 0.140842488088141 0.445701450093308 no 1474 0.443997188474997 2026 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).
SGTC_593 1203-0218 61.7 µM 0.139864012917637 0.446086391586741 no 1475 0.444383717638934 2163 3666956
SGTC_1094 duloxetine 25.4 µM 0.139768669188608 0.446123903444985 no 1476 0.444421384312898 2048 60834 A selective serotonin reuptake inhibitor.
SGTC_856 0433-0016 11.3 µM 0.13960558914686 0.446188066468867 no 1477 0.444485812186065 2064 3911780
SGTC_3175 9106517 49.47 µM 0.138407252900242 0.44665958896153 no 1478 0.444959282600601 2042 41468073
SGTC_3312 9133330 71.43 µM 0.138051497817456 0.4467995863612 no 1479 0.445099858887111 2141 17617324
SGTC_1711 st032263 62.8 µM 0.138045204116896 0.446802063129649 no 1480 0.445102345899174 2090 3958979
SGTC_467 ro 31-8220 72.8 µM 0.136803316478452 0.447290825321959 no 1481 0.445593131061243 2164 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7
SGTC_2622 2-methoxyxanthone 59.94 µM 0.136253664503056 0.447507174121114 no 1482 0.445810376277858 2134 71034 A hepatoprotective.
SGTC_1886 st057356 49.9 µM 0.135241194493932 0.447905733803731 no 1483 0.446210588883691 1972 24207747
SGTC_1117 retinoic acid 1.10837 µM 0.135074756699309 0.447971257228164 no 1484 0.446276384239815 2167 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR).
SGTC_2603 homopterocarpin 100 µM 0.133804641879637 0.448471324130717 no 1485 0.446778528258812 2054 101795 A weak amylase inhibitor.
SGTC_2869 9037858 32.47 µM 0.133536981485542 0.448576717284126 no 1486 0.446884359579425 2206 27187042
SGTC_1637 st007924 17.4 µM 0.132613745182911 0.448940275842174 no 1487 0.447249430677307 2138 683336
SGTC_157 1348-1695 65.819 µM 0.131949089098888 0.449202035405292 no 1488 0.447512280276404 2175 5380510
SGTC_1773 st048542 73.5835 µM 0.131394998971394 0.44942026800447 no 1489 0.447731422304374 1997 3237138
SGTC_2708 st078559 56 µM 0.131218161099306 0.449489920165522 no 1490 0.447801364847495 2174 17250902
SGTC_71 0417-1750 47.813 µM 0.130045642858161 0.449951786013131 no 1491 0.448265157749759 2187 6811472
SGTC_325 2810-4341 181 µM 0.129445211503821 0.450188327800988 no 1492 0.448502687489335 2182 774970
SGTC_508 roscovitine 141 µM 0.128157452647937 0.450695703954099 no 1493 0.449012185104907 2134 160355 A CDKinase inhibitor.
SGTC_3298 9116858 71.43 µM 0.1279362644417 0.450782860095682 no 1494 0.449099705986952 2135 2506942
SGTC_2001 4023502 57.655 µM 0.127734186018678 0.450862488367116 no 1495 0.449179667577206 2107 108941 YCR052W RSC6
SGTC_1771 st048882 4.1505 µM 0.127727949277772 0.450864945963781 no 1496 0.449182135462455 1992 4580403
SGTC_3301 9125354 19.7965 µM 0.124832359398361 0.452006159192369 no 1497 0.450328134332845 2136 41905162
SGTC_1388 3346-4487 254 µM 0.123555594292597 0.452509485906533 no 1498 0.450833576803342 2120 3345614
SGTC_447 ml7 120 µM 0.122555738384501 0.452903702726633 no 1499 0.451229452891643 2210 4216 Selective myosin light chain kinase inhibitor.
SGTC_1867 st057372 64 µM 0.121654289477868 0.453259160066758 no 1500 0.451586407983703 2184 688837
SGTC_509 pifithrin 175 µM 0.121649105491193 0.453261204313505 no 1501 0.451588460848516 2198 4817 A p53 inhibitor.
SGTC_1594 piperine 70.1 µM 0.121504868384551 0.453318083088122 no 1502 0.451645579431124 2079 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_3200 9114385 49.47 µM 0.119582887928228 0.454076091994428 no 1503 0.452406787947085 2070 17018030 YLR208W SEC13
SGTC_3284 9108171 64.8615 µM 0.118313467264021 0.454576830085613 no 1504 0.452909643506974 2087 8687505
SGTC_620 0109-0052 432 µM 0.117908321949091 0.454736659713163 no 1505 0.453070149643138 2200 493037
SGTC_1073 triclabendazole 3.09 µM 0.117511677258586 0.454893142948005 no 1506 0.453227295520974 2088 50248 An antihelmetic and likely tubulin inhibitor.
SGTC_1307 1187-1599 12.2 µM 0.117079451181884 0.455063671628252 no 1507 0.453398546657109 2098 1538471
SGTC_1276 0871-0068 94.2 µM 0.116381159688884 0.455339190134941 no 1508 0.453675233155915 2174 3414906
SGTC_529 4076-0302 30.3 µM 0.115663048413591 0.455622551156866 no 1509 0.453959796368673 2051 5816522
SGTC_289 k017-0060 526 µM 0.115571441558046 0.455658700123232 no 1510 0.453996098770454 2163 5512909
SGTC_74 000s-0487 160.283 µM 0.11456666576191 0.456055218566623 no 1511 0.45439430127804 2227 677548
SGTC_254 nsc-64875 3.808 µM 0.113771317547214 0.45636912087388 no 1512 0.45470953810442 2195 56993
SGTC_515 4092-1064 102 µM 0.110563422860108 0.45763546407517 no 1513 0.455981276964552 2218 717353
SGTC_2865 9030313 51.95 µM 0.108772580458623 0.458342602013406 no 1514 0.456691436187782 2104 42562754
SGTC_2719 novobiocin 32.65 µM 0.108452332478865 0.458469070150047 no 1515 0.456818445290921 2190 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication.
SGTC_2523 spermine 47.74 µM 0.108185564612265 0.458574421831223 no 1516 0.456924247757559 2195 1103 A DNA binding polyamine.
SGTC_276 colchicine 750 µM 0.107463549959168 0.458859573662232 no 1517 0.457210620372298 2118 2833 A microtubule depolymerizer.
SGTC_143 4032-1194 15.74 µM 0.107277008856274 0.458933249488257 no 1518 0.45728461177321 2110 1806963
SGTC_3278 9139605 49.47 µM 0.106120917626718 0.459389887868182 no 1519 0.457743207495115 2169 7958859
SGTC_2893 9048488 25.97 µM 0.105926089642249 0.459466847238752 no 1520 0.457820496987381 2101 6467338
SGTC_870 0573-2213 57.6 µM 0.105823290652148 0.459507454674547 no 1521 0.457861278639219 2215 3916321
SGTC_1479 0549-0158 134 µM 0.104826187152961 0.459901350209692 no 1522 0.458256865090531 2174 5440202
SGTC_2970 9090938 41.86 µM 0.104734893338583 0.459937416869604 no 1523 0.458293086668598 2219 17217104
SGTC_2588 indole-3-carbinol 100 µM 0.104500666564396 0.460029952328442 no 1524 0.458386019667455 2214 3712 Induces cell cycle arrest.
SGTC_3244 9134489 49.47 µM 0.104396759510845 0.460071003354125 no 1525 0.45842724708392 2104 16584271
SGTC_1401 3807-4679 7.6 µM 0.104207338900814 0.460145839698992 no 1526 0.458502405041425 2209 3291456
SGTC_523 1934-0222 13.7 µM 0.103673741143027 0.46035666122453 no 1527 0.458714132935062 2127 1361595
SGTC_2575 plumbagin 510 nM 0.103399772105941 0.46046490921094 no 1528 0.458822846505611 2119 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_564 3555-0129 330 µM 0.103184326309076 0.460550036121195 no 1529 0.458908339650535 2234 563260
SGTC_2101 5377231 179.231 µM 0.102661854593416 0.460756482566666 no 1530 0.459115674625926 2167 2844213
SGTC_1113 artemisinin 1.17947 µM 0.10193211735027 0.461044844403584 no 1531 0.459405278383832 2240 2240 An anti-malaria and mitochondrial poison.
SGTC_3332 9141069 11.198 µM 0.101218187669319 0.461326979573268 no 1532 0.459688629596228 2180 17332883
SGTC_1467 k284-1082 293 µM 0.100538419809479 0.461595632554659 no 1533 0.459958441371955 2251 3334705
SGTC_8 0354-0001 70 µM 0.10027590935639 0.461699384751782 no 1534 0.460062641313375 2170 4993152
SGTC_1172 0370-0043 85 µM 0.100270947887454 0.461701345701874 no 1535 0.460064610727185 2165 376585
SGTC_657 3534-0529 86.7 µM 0.0999845224833735 0.461814552849449 no 1536 0.460178306567379 2234 1049549
SGTC_953 1188-0045 9.7 µM 0.099644156505409 0.461949083561207 no 1537 0.460313418214898 2171 6144426
SGTC_2266 7929956 200 µM 0.0996262908828762 0.461956145124486 no 1538 0.4603205102775 2239 2967153
SGTC_1068 loratadine 26.9 µM 0.0980889321389031 0.462563845992654 no 1539 0.460930838008743 2116 3957 A H1 histamine antagonist.
SGTC_2744 captopril 92.04 µM 0.0977018406678894 0.462716872787649 no 1540 0.461084526955195 2238 44093 angiotensin-converting enzyme (ACE) inhibitor
SGTC_561 1550-0330 72.9 µM 0.096519385053169 0.46318436070077 no 1541 0.461554039378055 2131 6812934
SGTC_1406 3909-7906 11.9 µM 0.0960457481963592 0.463371628967435 no 1542 0.461742119338592 2227 X1406
SGTC_1969 st069479 40.1 µM 0.0956220626801135 0.463539154170257 no 1543 0.461910371003469 2224 3895485
SGTC_1135 dihydrocapsaicin 536.708 nM 0.0944152818401496 0.464016350506274 no 1544 0.462389638439442 2200 107982 A Capsaicinoid.
SGTC_2804 7954240 19.48 µM 0.0932239545084683 0.464487486858306 no 1545 0.462862822154534 2207 828705
SGTC_2811 7967822 32.47 µM 0.0929829854645523 0.464582789393461 no 1546 0.462958539144192 2204 2232244
SGTC_389 tpck 16.7 µM 0.0922383191131353 0.464877315522973 no 1547 0.463254346774384 2148 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.
SGTC_195 4234-0266 16.654 µM 0.0922310175196217 0.464880203502553 no 1548 0.463257247324643 2119 2303354
SGTC_2077 5212015 200 µM 0.0919685624911229 0.464984012858971 no 1549 0.46336150860145 2261 780900
SGTC_3253 9135987 49.47 µM 0.0896468121161674 0.465902442368172 no 1550 0.464283941724694 2228 4182430
SGTC_3168 9103419 49.47 µM 0.0870848134289147 0.466916119030517 no 1551 0.465302048325013 2249 16649256
SGTC_3178 9107506 49.47 µM 0.0869158042450987 0.466982996575445 no 1552 0.465369218544997 2210 8897194
SGTC_2537 larixol 68.93 µM 0.0866373576655804 0.467093180925422 no 1553 0.465479885203008 2214 6708759
SGTC_3277 9138724 49.47 µM 0.0863465609162565 0.467208255064154 no 1554 0.465595463200036 2159 15943418
SGTC_2114 5491910 81.25 µM 0.0856267086662332 0.467493126887559 no 1555 0.46588158299234 2221 2849228
SGTC_408 cantharidin 100 µM 0.0838729974320509 0.468187203865036 no 1556 0.466578704411014 2160 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_2774 tamoxifen 10.92 µM 0.0837602550720269 0.468231827926752 no 1557 0.466623524393097 2246 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.
SGTC_1371 2421-0008 32.7 µM 0.082002924358325 0.468927440581152 no 1558 0.467322193994241 2164 2827552
SGTC_3007 9078383 71.4286 µM 0.0819676130499262 0.468941419005245 no 1559 0.467336233903541 2185 6496995
SGTC_2741 miltefosine 3.04 µM 0.0817386088365352 0.469032074122434 no 1560 0.467427287827429 2221 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis.
SGTC_1349 flufenamic acid 69 µM 0.0812014582351498 0.469244720391222 no 1561 0.467640869921938 2231 3371 A non-steroidal anti-inflammatory.
SGTC_2539 epi(13)torulosol 80 µM 0.0796713041959464 0.469850523064396 no 1562 0.468249341408459 2174 6708597
SGTC_865 0488-0499 301 µM 0.0789866412964638 0.470121610364012 no 1563 0.468521624282508 2274 9634651
SGTC_3021 9087658 49.47 µM 0.0777119371777694 0.470626356993929 no 1564 0.469028599164955 2271 25237042
SGTC_2753 fluvastatin 17.09 µM 0.0776652232097078 0.470644855300022 no 1565 0.469047179187204 2203 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5
SGTC_1975 st070967 30.8 µM 0.0773700321810834 0.470761749723287 no 1566 0.469164590078428 2285 261391
SGTC_2690 usnic acid 100 µM 0.076622061667422 0.471057954201503 no 1567 0.469462103936293 2259 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_3185 9108267 49.47 µM 0.0761502312951059 0.471244812419477 no 1568 0.469649788664254 2170 4910486
SGTC_2764 methyldopa 94.69 µM 0.076141819300991 0.471248143865439 no 1569 0.469653134849339 2256 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent.
SGTC_2278 7948257 134.34 µM 0.0758792586871313 0.471352128126861 no 1570 0.469757579223838 2284 1247028
SGTC_2105 5350118 200 µM 0.0757604287903535 0.471399190051108 no 1571 0.469804849428456 2199 2133313
SGTC_871 0574-0004 149 µM 0.0755466872402281 0.471483842216242 no 1572 0.469889876297245 2139 9551173
SGTC_2700 st077718 96.8 µM 0.0753033229366298 0.47158022801687 no 1573 0.469986688835283 2179 904970
SGTC_1249 0481-0015 10.2 µM 0.0751632073913914 0.471635722321725 no 1574 0.470042428881391 2242 4227577
SGTC_956 1185-0240 191 µM 0.0749314750220822 0.471727503686822 no 1575 0.470134616749362 2220 1416193
SGTC_1944 st076371 56.9 µM 0.074771683279878 0.471790792674128 no 1576 0.470198186099776 2134 24208455
SGTC_1103 duloxetine 36.1 µM 0.0732870560690742 0.472378845344317 no 1577 0.470788845880729 2248 60835 A selective serotonin reuptake inhibitor.
SGTC_556 4058-0063 51.5 µM 0.0723584017201592 0.472746710915417 no 1578 0.471158344298317 2201 6615692
SGTC_186 3455-3465 67.277 µM 0.0723397791664043 0.472754088060796 no 1579 0.471165754203808 2284 755278
SGTC_2784 7567673 72.73 µM 0.0716409219849818 0.47303094033882 no 1580 0.471443836345622 2278 3471247
SGTC_1516 st013856 110 µM 0.0712417243436968 0.473189088342623 no 1581 0.471602687267584 2208 5281404 A mutagen and neurotoxin.
SGTC_2855 9016525 58.44 µM 0.0702959471321618 0.473563788685907 no 1582 0.47197905412457 2264 43811474
SGTC_2512 diallyl trisulfide 49.23 µM 0.0693843718364026 0.473924960971205 no 1583 0.472341834202788 2291 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent
SGTC_3063 1327-0034 4 µM 0.0674690954023087 0.474683875894513 no 1584 0.473104132121665 2268 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_972 1319-0219 195 µM 0.0672363522726479 0.474776105050955 no 1585 0.473196772830701 2198 23903702
SGTC_3064 1327-0027 10 µM 0.0671398389814454 0.474814350784746 no 1586 0.473235189254753 2225 16000455 YPR107C YTH1
SGTC_1344 1488-0097 29.1 µM 0.0669373166185425 0.474894605939856 no 1587 0.473315802639064 2230 747966
SGTC_2755 lomerizine 42.69 µM 0.0665801982008004 0.475036126588928 no 1588 0.473457955153251 2246 3949 A calcium channel blocker.
SGTC_237 nikkomycin 200 µM 0.0653182877966443 0.4755362277806 no 1589 0.473960290940442 2278 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine.
SGTC_1240 0356-0016 42.1 µM 0.0649228733151534 0.475692940418352 no 1590 0.474117704369485 2237 4305613
SGTC_3058 9093861 49.47 µM 0.0623222272817963 0.476723733985876 no 1591 0.475153114034701 2264 17217477
SGTC_2301 7769476 200 µM 0.0614134857328264 0.477083960389863 no 1592 0.475514956285605 2237 977820
SGTC_2353 9059630 146.67 µM 0.0611278734592171 0.477197181370768 no 1593 0.47562868542143 2253 4779114
SGTC_1138 3761-0006 1.03 µM 0.0608917075172114 0.477290802476264 no 1594 0.475722726817518 2287 12061087
SGTC_2996 9066192 71.4286 µM 0.0606978544662049 0.477367650806046 no 1595 0.475799920210137 2220 6472854
SGTC_1769 st044406 64.4 µM 0.0602990500204562 0.477525749777736 no 1596 0.475958729272454 2200 670903
SGTC_1293 1000-1278 195 µM 0.0586190152534985 0.478191808402917 no 1597 0.476627782371752 2261 678847
SGTC_3026 9090633 49.47 µM 0.0564778350027782 0.479040778627232 no 1598 0.477480576220856 2276 25236842
SGTC_696 1560-0013 611 µM 0.0551058288108616 0.479584824354577 no 1599 0.478027076241661 2283 1650269
SGTC_872 0588-0139 234 µM 0.0550593485604771 0.479603255979384 no 1600 0.478045591069584 2315 2047100
SGTC_2731 amoxapine 43.43 µM 0.05505717326671 0.479604118587651 no 1601 0.478046457571881 2320 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine.
SGTC_850 0388-0143 75.9 µM 0.0545602839243195 0.479801161528823 no 1602 0.478244390219316 2246 67273
SGTC_345 1362-0200 395 µM 0.0537766097204582 0.480111939869426 no 1603 0.478556572643128 2229 1419823
SGTC_2024 5144227 134 µM 0.0537435827203381 0.480125037512979 no 1604 0.478569729483519 2295 3475211
SGTC_2562 3',7'-dimethoxyflavone 64.92 µM 0.0534078512288026 0.480258181047884 no 1605 0.478703474883368 2317 688664
SGTC_2170 morpholine 200 µM 0.053153609471408 0.480359009059076 no 1606 0.478804758803255 2267 121171 Reacts with secondary amines.
SGTC_1125 tnp00248 1.32998 µM 0.0527128972124278 0.480533791112992 no 1607 0.478980331412036 2302 24207736
SGTC_1642 st009582 77.7 µM 0.0509162321103402 0.481246368812224 no 1608 0.479696135466468 2301 6739311
SGTC_3180 9109287 49.47 µM 0.0507662682267618 0.481305848925551 no 1609 0.479755885128741 2280 18891271
SGTC_2958 9077254 16.72 µM 0.0502632771120522 0.48150535311531 no 1610 0.479956293690271 2257 16457351
SGTC_804 1595-0054 20.9 µM 0.0499312557603055 0.481637047149091 no 1611 0.480088584932615 2216 761523 Stimulates phospholipase C.
SGTC_3165 9101544 49.47 µM 0.0499240032276435 0.481639923839759 no 1612 0.480091474670565 2299 5002184
SGTC_373 0844-0104 25.9 µM 0.0495736162879858 0.481778904679291 no 1613 0.480231085962572 2325 5375804
SGTC_3182 9108849 49.47 µM 0.0494253422645425 0.481837718179224 no 1614 0.480290166315906 2260 17133045
SGTC_2904 7225135 42.03 µM 0.0493951378017068 0.481849698951875 no 1615 0.480302201453094 2317 4446116
SGTC_570 0987-0065 62.6 µM 0.0484460994254824 0.482226148736007 no 1616 0.480680360192233 2329 3104428
SGTC_2923 7992654 58.14 µM 0.0482028786140118 0.482322628349626 no 1617 0.480777278027082 2298 2985126
SGTC_828 2074-0507 139 µM 0.0480672056348713 0.482376446877802 no 1618 0.480831341046905 2312 X828
SGTC_1050 3232-1156 69.3 µM 0.0478246229370766 0.482472674972381 no 1619 0.480928006369795 2252 700529
SGTC_308 4092-1169 104 µM 0.0472362426191228 0.482706078853668 no 1620 0.481162471157938 2292 2268590 YDL196W YDL196W
SGTC_409 arachidonic acid 100 µM 0.0469855354255049 0.482805533394509 no 1621 0.481262377927339 2338 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes.
SGTC_952 1185-0122 232 µM 0.0467107264721812 0.482914550235963 no 1622 0.481371890595225 2318 678600
SGTC_264 promethazine 12.5 mM 0.0466091763834804 0.482954835527737 no 1623 0.481412359142113 2335 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3
SGTC_713 1488-1073 324 µM 0.0464593442211419 0.483014274812476 no 1624 0.481472068842758 2337 3312542
SGTC_507 nimesulide 162 µM 0.0428513560880656 0.484445695489874 no 1625 0.482910012659997 2324 4495 A COX2 inhibitor.
SGTC_1080 nisoldipine 24.4 µM 0.0426112849171531 0.484540947809275 no 1626 0.483005699799539 2333 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class.
SGTC_2930 9013230 14.89 µM 0.0424923662049547 0.484588131157576 no 1627 0.483053098570829 2311 2995857
SGTC_2844 9010103 25.97 µM 0.0418174155841601 0.484855935218774 no 1628 0.483322125763974 2270 2480525
SGTC_2163 5671233 125 µM 0.0399675327738456 0.485589958578433 no 1629 0.484059505346916 2329 701023
SGTC_2110 5483698 200 µM 0.0392470256144692 0.485875865219595 no 1630 0.484346720738896 2291 2848765 YHR062C RPP1
SGTC_99 0109-0120 622.8 µM 0.0382856153113695 0.486257376653334 no 1631 0.484729979848457 2330 759414
SGTC_2076 5212012 200 µM 0.0378772706956714 0.486419421742388 no 1632 0.484892767699528 2351 604802
SGTC_177 1327-0068 8.361 µM 0.0376337040145266 0.486516078388987 no 1633 0.484989867515057 2355 15389900 YOR207C | YLR033W RET1 | RSC58
SGTC_3281 9140613 49.47 µM 0.0372699328940046 0.486660438263283 no 1634 0.485134889452259 2178 16013766
SGTC_1255 0566-0045 221 µM 0.03676317791689 0.486861543131335 no 1635 0.485336916977229 2293 2788469
SGTC_399 oxolinic acid 75 µM 0.0364946237061295 0.486968119779995 no 1636 0.485443982758249 2270 4628 A DNA gyrase inhibitor.
SGTC_522 1273-0010 11.6 µM 0.0353062891376655 0.487439725447559 no 1637 0.485917754226152 2288 5705015
SGTC_1853 st056710 91.2 µM 0.0343007414412925 0.487838803569431 no 1638 0.486318666817134 2351 269167
SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM 0.0338126784458104 0.488032508654883 no 1639 0.486513262894817 2320 6708739 YPR165W RHO1
SGTC_3302 9125395 16.351 µM 0.0332888730561705 0.488240402514932 no 1640 0.486722113429198 2280 17599668
SGTC_2832 7992762 51.95 µM 0.0324041792483788 0.488591537114878 no 1641 0.487074864840762 2318 2985177
SGTC_3113 9123498 49.47 µM 0.0311892030137659 0.489073775027201 no 1642 0.487559325236846 2357 8897275
SGTC_3236 9132701 49.47 µM 0.0296007824815269 0.489704261220688 no 1643 0.488192720629135 2341 24282524
SGTC_991 3996-0057 64.7 µM 0.0293211375044649 0.489815262429291 no 1644 0.488304234429023 2333 715343
SGTC_19 0279-0214 38.434 µM 0.0283440701462438 0.490203101949652 no 1645 0.488693865905828 2358 3566274 YBR002C RER2
SGTC_785 1270-0111 65.3 µM 0.0272817633595274 0.49062478711687 no 1646 0.489117501092938 2362 6741994
SGTC_1475 4092-1048 11.7 µM 0.0267728910344966 0.490826788919245 no 1647 0.489320437642811 2289 2881759
SGTC_2619 obliquin 87.91 µM 0.025855302606348 0.49119104045183 no 1648 0.489686375734473 2342 6708593 A bioactive alkalod. YER133W GLC7
SGTC_2545 solidagenone 89.61 µM 0.0249280447446035 0.491559137883654 no 1649 0.490056178855002 2365 6708572 An anti ulcer agent
SGTC_1322 1348-1070 12 µM 0.0224123866186488 0.492557824516582 no 1650 0.491059499870714 2353 6758089
SGTC_2460 5552655 174.22 µM 0.0210418718441803 0.493101922762857 no 1651 0.491606127079519 2243 5401989
SGTC_3320 9137005 35.139 µM 0.0200976073801501 0.493476805957279 no 1652 0.491982754397503 2294 4908713
SGTC_663 1486-0733 13.9 µM 0.0193990836376318 0.493754131155995 no 1653 0.492261370711512 2348 722445 YPR165W RHO1
SGTC_2215 7188065 200 µM 0.0188018666899932 0.493991238321153 no 1654 0.49249958234184 2374 940217
SGTC_2368 9071271 200 µM 0.0186322434020801 0.494058582575965 no 1655 0.492567240390751 2346 27209959
SGTC_2135 5326629 150.42 µM 0.0175257441810163 0.494497891685585 no 1656 0.49300859755606 2352 5020077
SGTC_1160 4092-0570 10.5 µM 0.016814349616543 0.494780337477967 no 1657 0.493292361088575 2363 4994975
SGTC_2239 6685329 187.64 µM 0.0167524959485361 0.49480489543575 no 1658 0.493317033656767 2277 805680
SGTC_2713 st079149 53.4 µM 0.0154959444882026 0.495303792176142 no 1659 0.493818259967554 2357 3103253
SGTC_1523 st012844 44.7 µM 0.0153965141196157 0.495343269981274 no 1660 0.493857922213813 2285 4274103
SGTC_2939 9044578 71.43 µM 0.0147939746457061 0.495582503043406 no 1661 0.494098273296402 2375 2653634
SGTC_2199 6590217 200 µM 0.0141253813873312 0.49584796404245 no 1662 0.494364975527778 2364 703109
SGTC_2936 9038235 15.59 µM 0.0136316424060156 0.496044001371674 no 1663 0.494561929911997 2383 4749415
SGTC_1229 0139-0193 12.2 µM 0.0133385165492849 0.496160386419015 no 1664 0.494678859577148 2382 3090752
SGTC_1998 st075797 76.8 µM 0.00991880026428261 0.497518199616593 no 1665 0.496043036086559 2389 24208315
SGTC_3082 9117008 49.47 µM 0.00883232378243427 0.49794959658767 no 1666 0.496476458420931 2381 41448529
SGTC_2013 4024628 200 µM 0.00869166595485234 0.498005446450849 no 1667 0.496532570621397 2385 5230760
SGTC_2683 piperine 63.03 µM 0.00846439943505399 0.498095685407376 no 1668 0.4966232335092 2393 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_2347 9049783 174.81 µM 0.00787618370059488 0.498329244113616 no 1669 0.496857889800076 2387 6467988 YPL169C MEX67
SGTC_1729 st035615 45.989 µM 0.00709942280100988 0.498637667993721 no 1670 0.497167763869886 2301 17385451
SGTC_474 dl-dihydrosphingosine 5 µM 0.00552744346435002 0.499261846878645 no 1671 0.497794880328249 2392 3058739 A sphingolipid protein kinase C inhibitor.
SGTC_2431 5490079 200 µM 0.00542794007732 0.499301356325456 no 1672 0.497834575840824 2395 5722345
SGTC_2384 9036245 200 µM 0.00499423364654096 0.499473566630337 no 1673 0.498007597322736 2371 6462766
SGTC_2154 5570129 200 µM 0.00498875002790718 0.499475743992422 no 1674 0.498009784942806 2396 673366
SGTC_3087 9117406 49.47 µM 0.00448017803263458 0.499677681030534 no 1675 0.49821267353826 2352 42546093
SGTC_2907 7721985 69.9 µM 0.00429459808412036 0.499751368684064 no 1676 0.498286708513451 2388 3267881
SGTC_1455 4262-0120 131 µM 0.004079795777012 0.499836659579148 no 1677 0.498372401484305 2385 1529587
SGTC_1164 k060-0068 93.7 µM 0.00407782186572124 0.499837443354108 no 1678 0.498373188954426 2398 5963676
SGTC_372 0155-0182 15.9 µM 0.00325903484785193 0.499837443354108 no 1679 0.498699835507465 2368 771486
SGTC_2921 7974240 10.71 µM 0.00260710370622767 0.49957858308859 no 1680 0.498959917280433 2397 2979074 YDR527W RBA50
SGTC_1802 st050112 57.9 µM 0.00258357491017187 0.499569240585571 no 1681 0.498969303880374 2388 4662563
SGTC_2037 5169046 200 µM 0.00208194028204174 0.499370058209235 no 1682 0.499169426596239 2400 5718022
SGTC_1268 0828-0275 2.46 µM 0.00165648311598909 0.499201123482917 no 1683 0.499339159150478 2398 745337
SGTC_1480 1070-0044 41.2 µM 0.00135767534818818 0.499082477055417 no 1684 0.499458366066946 2398 3124987
SGTC_2576 guaiol 23.12 µM 0.00133940073475453 0.499075220828918 no 1685 0.499465656576274 2402 227829
SGTC_1585 2',4'-dihydroxychalcone 10.4 µM 0 0.498543391412147 no 1686 0.5 2406 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_2880 9042983 58.44 µM 0 0.498543391412147 no 1687 0.5 2403 6464714
SGTC_1960 st011366 51.8 µM -0.000642595727460733 0.498288239873655 no 1688 0.499743641412754 2408 3972846
SGTC_2685 mycophenolic acid 18.85 µM -0.00121616724215947 0.498060495943624 no 1689 0.499514819586665 2410 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_1378 2093-0007 380 nM -0.00123454186388399 0.498053200074336 no 1690 0.499507489178677 2408 3618014
SGTC_1622 st003707 19.4 µM -0.0013481284161719 0.498008099152889 no 1691 0.49946217473829 2416 10140899
SGTC_1112 tnp00069 1.16933 µM -0.00179517984810509 0.49783059219983 no 1692 0.499283827242331 2419 145826
SGTC_3106 9121286 49.47 µM -0.00236497274712147 0.497604349951733 no 1693 0.499056513258678 2423 15943471
SGTC_2795 7780010 54.55 µM -0.00315585539641114 0.497290322991411 no 1694 0.498740997941361 2411 953673
SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM -0.00337789542782293 0.497202160323916 no 1695 0.49865241725776 2422 688761
SGTC_1295 1013-0063 9.78 µM -0.00362815009075378 0.497102794988395 no 1696 0.498552580704668 2411 6826038
SGTC_2166 5933061 31.504 µM -0.00400913451238155 0.496951522850004 no 1697 0.498400591019788 2415 2877375
SGTC_3040 9091894 49.47 µM -0.00428065004017683 0.49684371625547 no 1698 0.498292272926761 2407 25236966
SGTC_112 phenothiazine 287.218 µM -0.00511306806903997 0.49651320199567 no 1699 0.497960189852644 2418 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.
SGTC_2650 prasterone 100 µM -0.00530223067695699 0.496438094698439 no 1700 0.497884725913871 2413 16759247 A steroid and weak partial agonist of the androgen receptor.
SGTC_440 fluspirilene 35.1 µM -0.0071005298707935 0.495724083988279 no 1701 0.497167322224074 2432 3396 An atypical antipsychotic.
SGTC_1980 st071811 45.7 µM -0.00946681670236373 0.49478457628231 no 1702 0.496223342967757 2453 4974850
SGTC_3248 9135562 49.47 µM -0.0099180561404649 0.494605419837645 no 1703 0.49604333293441 2425 17650701
SGTC_1289 0976-0073 69.1 µM -0.0116099885581802 0.493933678703833 no 1704 0.495368388739962 2447 3391136
SGTC_1904 st060225 78 µM -0.0116656500902586 0.493911579911088 no 1705 0.495346184505135 2421 66595
SGTC_2502 avocadyne acetate 18.59 µM -0.0122608212114149 0.493675285705996 no 1706 0.49510876257474 2423 3952079
SGTC_292 k038-0015 474 µM -0.0123024477751249 0.493658759254046 no 1707 0.495092157230899 2430 46368540
SGTC_3262 9137218 49.47 µM -0.01285647081175 0.493438803757504 no 1708 0.494871151507073 2424 17650664
SGTC_312 4092-0653 6.84 µM -0.0130392181707858 0.493366250735597 no 1709 0.494798251969962 2468 1148278
SGTC_2330 7979373 200 µM -0.0136152084066322 0.493137576745625 no 1710 0.494568485520806 2433 1863007
SGTC_1382 3002-2117 298 µM -0.0142311262835694 0.492893053572447 no 1711 0.494322793657726 2422 1497314
SGTC_466 geldanamycin 89.2 µM -0.0149615670449795 0.49260306758087 no 1712 0.494031421001759 2435 5288382 HSP90 inhibitor.
SGTC_753 1322-0200 289 µM -0.0166679330331011 0.491925653424224 no 1713 0.493350764669372 2471 5403907
SGTC_2949 9072542 2.23 µM -0.0167224421709873 0.491904014089683 no 1714 0.493329021700016 2452 16457352
SGTC_1501 4491-0275 38.4 µM -0.0175459627134882 0.491577091353514 no 1715 0.493000532768691 2433 5104718
SGTC_2638 epoxomicin 18 µM -0.0176608841026342 0.491531470088841 no 1716 0.492954692870659 2446 9915668 A protesome inhibitor.
SGTC_2259 7964009 200 µM -0.017861916601836 0.491451664873575 no 1717 0.492874505156428 2524 313134
SGTC_206 4546-0025 72.014 µM -0.0179925679356058 0.491399799523359 no 1718 0.492822391190456 2446 6620745 YIL048W NEO1
SGTC_837 0091-0265 12.5 µM -0.0189389767820014 0.491024102999546 no 1719 0.492444893067207 2438 759367
SGTC_2367 9070478 135.38 µM -0.0195583520673984 0.490778233487297 no 1720 0.49219784385385 2448 572802
SGTC_577 r071-0003 38.6 µM -0.0197172587691578 0.490715153854215 no 1721 0.492134461474622 2442 4568517 YMR134W ERG29
SGTC_2131 toluylene red 5.2905 µM -0.0202268693128051 0.490512860334909 no 1722 0.491931196827906 2448 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain.
SGTC_1662 st014054 52 µM -0.0214967669359898 0.49000877619713 no 1723 0.491424691239786 2442 2838777
SGTC_1503 4585-0012 61.3 µM -0.0221685641661256 0.489742113601351 no 1724 0.491156746793384 2467 2922052
SGTC_1070 indatraline 8.81 µM -0.0228589452899726 0.489468079109534 no 1725 0.490881394371625 2469 10314472 A monamine transport inhibitor. YGL099W LSG1
SGTC_2888 9058547 12.99 µM -0.0242870385859667 0.488901238833807 no 1726 0.490311825896468 2457 16476514
SGTC_1554 st069299 38.7 µM -0.0252984399505546 0.488499805845482 no 1727 0.489908459136642 2470 24207999
SGTC_2894 9048625 32.47 µM -0.0262258908878609 0.488131703658141 no 1728 0.489538582519924 2452 4092861
SGTC_2876 9059903 25.97 µM -0.0263799251903526 0.488070568927175 no 1729 0.489477152977563 2448 6916095
SGTC_2435 5706476 10.6 µM -0.0274960535832301 0.487627596782295 no 1730 0.489032043721624 2467 5725375
SGTC_978 1416-0512 87.4 µM -0.0277799663708728 0.487514919097915 no 1731 0.488918822158014 2482 6814003
SGTC_3081 9117243 49.47 µM -0.0278797773623433 0.487475306918424 no 1732 0.488879018750374 2467 45595589
SGTC_654 1124-0271 80.9 µM -0.0284123711823603 0.487263937486583 no 1733 0.488666628704318 2479 5403748
SGTC_2155 5570423 76 µM -0.0284943976852863 0.487231384110756 no 1734 0.488633918108046 2461 797402
SGTC_3025 9087895 49.47 µM -0.0291894546916034 0.486955544360661 no 1735 0.488356745794316 2460 17173641
SGTC_1356 1502-0781 85.8 µM -0.0292239372872294 0.486941859787601 no 1736 0.488342995095121 2458 567702
SGTC_1039 k821-0043 94 µM -0.0309726709627691 0.486247887480342 no 1737 0.487645667312522 2435 15992768
SGTC_851 0394-0702 453 µM -0.0319555146784026 0.485857871207836 no 1738 0.487253763453397 2453 762646
SGTC_2775 cyproheptadine 69.59 µM -0.0328625954754249 0.485497931497507 no 1739 0.486892080580237 2460 2913 A selective serotonin reuptake inhibitor.
SGTC_936 3005-4620 401 µM -0.0329004597237601 0.485482906799106 no 1740 0.48687698309453 2463 777207
SGTC_908 3448-7491 47.7 µM -0.0331853631064829 0.485369856560282 no 1741 0.486763385121711 2471 1203031
SGTC_2331 7980721 200 µM -0.0338564512564292 0.485103572087428 no 1742 0.486495810062598 2518 2981221
SGTC_2643 anethole 100 µM -0.0344285465494698 0.484876572733247 no 1743 0.486267710052904 2473 637563 An anti-fungal, anti-helmenthic and channel blocker.
SGTC_1000 4048-0884 8.67 µM -0.0351939666219608 0.484572872507658 no 1744 0.485962536595392 2508 13040088
SGTC_279 1273-0055 2.93 µM -0.0354685258595592 0.484463936195145 no 1745 0.485853071651087 2461 2847562
SGTC_352 k048-0007 5.11 µM -0.037763658539902 0.483553347191865 no 1746 0.484938059987659 2469 6811911
SGTC_2231 micatex 6.853 µM -0.0377643498293757 0.483553072936921 no 1747 0.484937784399641 2495 20737 An antifungal of unknown mechanism.
SGTC_3309 9129340 25.759 µM -0.0379886889132141 0.483464071410897 no 1748 0.484848350229657 2515 17158987
SGTC_2732 terfenadine 20 µM -0.039605720624082 0.482822574803664 no 1749 0.484203733310367 2475 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.
SGTC_1316 1272-0050 65.9 µM -0.0397259015676864 0.482774899282221 no 1750 0.484155825753835 2491 7340392
SGTC_3290 9121031 71.43 µM -0.0410231148313504 0.482260313393658 no 1751 0.483638734199996 2501 17014854
SGTC_2647 atorvastatin 60.16 µM -0.0410248454538173 0.482259626900106 no 1752 0.483638044362254 2522 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7
SGTC_3349 9149703 23.001 µM -0.0410953072201296 0.48223167656905 no 1753 0.483609957870435 2463 4910494
SGTC_1808 st050063 61.5 µM -0.0412754255629725 0.482160228752991 no 1754 0.483538161965268 2464 4011993
SGTC_2306 7482397 179.52 µM -0.0416499029961385 0.482011686058539 no 1755 0.48338889544611 2490 891448
SGTC_3033 9090887 49.47 µM -0.0419956009036407 0.481874561457248 no 1756 0.483251102497716 2473 19325384
SGTC_94 0334-0113 514.748 µM -0.0439130130696827 0.481114039739113 no 1757 0.482486871189077 2478 6795178
SGTC_2802 7925815 54.55 µM -0.0443281304388172 0.480949396680929 no 1758 0.482321424430166 2492 1262923
SGTC_98 0074-0023 107.663 µM -0.0452841024055737 0.480570253309961 no 1759 0.481940429440748 2536 3563821
SGTC_1211 1056-0033 32.3 µM -0.0453428394205585 0.480546958479068 no 1760 0.481917020806989 2507 6741922
SGTC_2337 9009472 200 µM -0.0459262331911725 0.48031559080342 no 1761 0.481684522585186 2503 5742383
SGTC_1072 oxiconazole 14.9 nM -0.0465219508415036 0.480079342453528 no 1762 0.481447119392067 2482 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_1318 1280-3875 124 µM -0.0469875057254791 0.479894718624056 no 1763 0.481261592758575 2532 373245
SGTC_2983 9022671 12.99 µM -0.047476728706555 0.479700713450248 no 1764 0.481066638609111 2574 6405161
SGTC_3334 9142812 21.919 µM -0.0483062569547973 0.479371768592778 no 1765 0.480736084024199 2579 45283678
SGTC_998 3996-0085 177 µM -0.049515353172794 0.478892333371083 no 1766 0.48025430107256 2526 715391
SGTC_3126 9127922 49.47 µM -0.0495927863223573 0.478861630330695 no 1767 0.480223447620526 2626 45595682
SGTC_2403 6032726 181.2 µM -0.0501587471590756 0.478637224857235 no 1768 0.479997942573505 2523 2881040
SGTC_2497 7-hydroxyflavone 100 µM -0.0504812217402899 0.478509365569288 no 1769 0.479869456601996 2528 5281894
SGTC_2248 tofa 1.1 µM -0.0510947559360051 0.478266108962075 no 1770 0.479625007346698 2491 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_1508 1080-0625 72.9 µM -0.0511341980879967 0.478250471048493 no 1771 0.479609292746741 2471 767111
SGTC_2937 9044753 11.33 µM -0.0512566760761181 0.478201911533485 no 1772 0.479560495089477 2500 6465530 YGL099W LSG1
SGTC_2456 5770359 74.46 µM -0.0514647544862552 0.47811941429522 no 1773 0.479477593230689 2499 3118787
SGTC_613 3914-0030 117 µM -0.0514853205466823 0.47811126048145 no 1774 0.479469399422321 2470 1145395
SGTC_732 3970-1727 52.7 µM -0.0523689515272498 0.477760936529691 no 1775 0.479117356624365 2519 1275699
SGTC_2815 7968870 71.43 µM -0.0530851532005235 0.477477004123504 no 1776 0.478832030401203 2510 2977326 YHR190W ERG9
SGTC_2835 9006588 71.43 µM -0.0535362652955062 0.477298170212621 no 1777 0.478652318270155 2671 2345538
SGTC_533 1222-0222 6.71 µM -0.053601088109163 0.477272472945076 no 1778 0.478626494787225 2666 3982874
SGTC_2798 7813637 45.45 µM -0.0560418904564255 0.476304951975173 no 1779 0.477654217910449 2561 956368
SGTC_3060 1327-0027 12.5 µM -0.0567082842160447 0.476040821093515 no 1780 0.477388787393611 2537 16000455 YPR107C YTH1
SGTC_535 2293-4129 48.2 µM -0.0568624270514871 0.475979726753684 no 1781 0.477327392365718 2491 396118 YIL048W NEO1
SGTC_360 0957-0399 1.01 µM -0.0579220120121593 0.475559776801866 no 1782 0.476905374752506 2561 6752301 YPR165W RHO1
SGTC_1119 parthenolide 318.541 nM -0.0595099899237194 0.474930457531645 no 1783 0.476272954386065 2660 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs.
SGTC_823 0417-1665 178 µM -0.0596864307410414 0.474860537465028 no 1784 0.476202689583429 2574 3429856
SGTC_1341 1486-1360 280 µM -0.0610987897782661 0.474300875114128 no 1785 0.47564026648452 2517 3976547
SGTC_852 0418-0143 439 µM -0.0616081846261663 0.474099034351905 no 1786 0.475437429468611 2514 5369229
SGTC_411 enrofloxacin 100 µM -0.062185324811735 0.473870358459739 no 1787 0.475207624487331 2533 71188 A bacterial gyrase inhibitor.
SGTC_2270 7924575 90.91 µM -0.0628025039423555 0.473625827767237 no 1788 0.474961885974839 2574 1262135
SGTC_2553 4-methylesculetin 85.09 µM -0.0633369647504001 0.473414078678829 no 1789 0.474749090612756 2518 5319502
SGTC_388 3',4'-dichloroisocoumarin 16.7 µM -0.0638630110872694 0.473205670671534 no 1790 0.474539652502801 2609 1609 A potent and irreversible inhibitor of serine proteases.
SGTC_225 nsc-122657 1.016 µM -0.0651481759498571 0.472696547534435 no 1791 0.474028011506858 2636 275685
SGTC_2693 st077581 40.7 µM -0.0659268094752916 0.472388110432328 no 1792 0.473718048067482 2520 25238761
SGTC_2292 7671323 168.05 µM -0.0661038253996567 0.472317992098657 no 1793 0.473647582643389 2589 937504
SGTC_1157 4092-0394 27.6 µM -0.0670816702428094 0.471930670424852 no 1794 0.473258343024644 2664 3659885
SGTC_934 2950-0684 338 µM -0.0671258568329292 0.471913168861174 no 1795 0.473240754769441 2575 1121253
SGTC_1942 st076330 65.2 µM -0.067764041478844 0.471660400743187 no 1796 0.472986734340052 2648 24208414
SGTC_2336 9001819 198.65 µM -0.0686994573081823 0.471289927842972 no 1797 0.47261442509517 2581 2989602
SGTC_1111 tnp00062 510.699 nM -0.0700986178586447 0.470735834590065 no 1798 0.472057583393551 2642 676306
SGTC_1308 1187-1617 41.4 µM -0.0708053126274643 0.470455991959029 no 1799 0.471776351787186 2518 2882570
SGTC_543 3844-1095 191 µM -0.0715248865532469 0.470171064328468 no 1800 0.471490009335876 2619 4230703
SGTC_2817 7995342 71.43 µM -0.0715741972417894 0.470151539473546 no 1801 0.471470387507055 2535 18879975
SGTC_1266 0828-0227 32.9 µM -0.0729724673703507 0.469597916301876 no 1802 0.47091401346943 2608 3913820
SGTC_2442 5158906 48.48 µM -0.0734438700893604 0.469411284966932 no 1803 0.470726454275221 2638 1893835
SGTC_925 2064-1272 59.6 µM -0.0738106046339561 0.469266097073777 no 1804 0.470580544383557 2574 6815817
SGTC_1418 3966-3099 2.4 µM -0.0738414730566987 0.469253876646102 no 1805 0.470568263178269 2546 740335
SGTC_549 1661-1316 519 µM -0.0742658714538863 0.469085865498907 no 1806 0.470399416324018 2552 2857282
SGTC_2491 paeonol 100 µM -0.0744426455081211 0.469015885679582 no 1807 0.47032908835479 2540 11092 Increases levels of cortical cytochrome oxidase.
SGTC_1304 1165-0502 251 µM -0.0746364496466939 0.468939165234386 no 1808 0.470251986183108 2569 767425
SGTC_876 0720-0963 56.8 µM -0.0753333145128437 0.468663309763218 no 1809 0.46997475781695 2557 765861
SGTC_3107 9121808 49.47 µM -0.0761415753190922 0.468343376819376 no 1810 0.469653231902291 2534 662681
SGTC_2441 5730946 39.09 µM -0.0765467312333144 0.468183012100085 no 1811 0.46949206842906 2635 1774275
SGTC_1820 st053765 18.6 µM -0.0769045286348495 0.468041396640701 no 1812 0.469349747444814 2604 3690829
SGTC_1571 st070080 73.4 µM -0.0776730499267774 0.467737231224588 no 1813 0.469044066182615 2616 4315245
SGTC_760 0568-0725 82.9 µM -0.0782727360060247 0.467499900495917 no 1814 0.468805552212641 2563 3916171
SGTC_1074 carmofur 3.8 µM -0.0786044872137756 0.467368612167848 no 1815 0.46867360915235 2542 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_1433 4060-0023 7.6 µM -0.0789016628959985 0.467251009887094 no 1816 0.468555420283747 2628 3840627
SGTC_3104 9120930 49.47 µM -0.0802347463924047 0.466723499821604 no 1817 0.468025277804173 2609 17014836
SGTC_2992 9074591 71.4286 µM -0.0805627062947636 0.466593732814703 no 1818 0.467894862913304 2546 17741321
SGTC_3100 9120536 49.47 µM -0.0807297840698172 0.466527624930371 no 1819 0.467828424926715 2519 16421196
SGTC_1947 st076332 61.6 µM -0.0810127050986887 0.466415683299283 no 1820 0.467715924254917 2540 24208416
SGTC_3331 9141060 1.957 µM -0.0830553274991989 0.465607570774879 no 1821 0.466903773277261 2566 4906567 YPR165W RHO1
SGTC_723 4182-0001 115 µM -0.0852864631074283 0.464725039856304 no 1822 0.466016826597729 2580 744821 YLR208W SEC13
SGTC_2378 9074213 121.43 µM -0.0855610062385164 0.464616455578133 no 1823 0.465907698627644 2566 657714
SGTC_149 3970-0822 46.1 µM -0.0856007242229385 0.464600746975976 no 1824 0.46589191136398 2555 3114250 YBL034C STU1
SGTC_361 000s-0510 1.45 µM -0.0858039113581697 0.464520386614899 no 1825 0.465811148567146 2616 660
SGTC_1481 3346-2004 36 µM -0.0862374769470976 0.46434891658936 no 1826 0.465638819683588 2558 2770522
SGTC_1714 st033236 13.627 µM -0.0888101024667253 0.4633316111164 no 1827 0.464616414405934 2645 2916566
SGTC_2345 9052315 157.45 µM -0.0888771607195524 0.463305097131587 no 1828 0.464589767406358 2637 6469265
SGTC_1795 st049545 62.3 µM -0.0888899958547459 0.46330002230009 no 1829 0.464584667114991 2557 5291882
SGTC_2463 5473429 200 µM -0.0890198786230145 0.463248668820841 no 1830 0.464533055990677 2642 5399405
SGTC_694 1315-0438 43.2 µM -0.0898606580529231 0.462916253515562 no 1831 0.464198972474172 2612 6793154
SGTC_1892 st058411 7.36 µM -0.0901610660927455 0.462797488762608 no 1832 0.464079611515443 2619 3934738
SGTC_3340 9146634 11.102 µM -0.0906803674869114 0.462592193489886 no 1833 0.463873285413105 2603 4907387
SGTC_2149 5554786 194.827 µM -0.0923744920684628 0.461922525259445 no 1834 0.463200252570778 2583 745063 YPR165W RHO1
SGTC_1362 1611-0397 101 µM -0.0936585537690398 0.461415022038192 no 1835 0.462690197399713 2585 27816
SGTC_714 4296-0578 26.1 µM -0.094038480276879 0.461264874651878 no 1836 0.46253929465986 2615 1589775
SGTC_1056 3448-1962 115 µM -0.0945699306311643 0.461054854138001 no 1837 0.462328217321218 2656 715507
SGTC_75 0159-0059 199.013 µM -0.0947886593978836 0.460968419247924 no 1838 0.462241347400601 2648 5377270
SGTC_1462 k081-0014 26.5 µM -0.0953249865991113 0.460756487024183 no 1839 0.462028348292156 2554 3270634
SGTC_1912 st060209 90.8 µM -0.0964579933213124 0.46030881079078 no 1840 0.461578417390551 2635 688787
SGTC_2053 5265679 138 µM -0.0983929371860943 0.4595443879273 no 1841 0.460810141388521 2590 764595
SGTC_429 1112-0049 25.5 µM -0.0985140553574762 0.459496543679587 no 1842 0.460762055843496 2601 2836170
SGTC_2430 5571206 200 µM -0.100295273449237 0.458792992845355 no 1843 0.460054954907224 2622 1731771
SGTC_1569 carminic acid 40.6 µM -0.100985307768887 0.458520475592281 no 1844 0.45978106162541 2617 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_2376 9072922 81.32 µM -0.101222522748486 0.458426796089447 no 1845 0.459686908986779 2717 17087968
SGTC_700 3453-2283 142 µM -0.102587218274566 0.457887903810246 no 1846 0.459145293826096 2703 565664
SGTC_3327 9140648 26.9345 µM -0.102704930048784 0.457841425284035 no 1847 0.459098580363423 2608 8029710
SGTC_1923 st058458 19.1 µM -0.103167966055169 0.457658600990646 no 1848 0.458914831799915 2675 3534982
SGTC_3155 9099265 49.47 µM -0.103613742974679 0.457482599707653 no 1849 0.458737940526273 2676 25236499
SGTC_3267 9137951 49.47 µM -0.104464331133561 0.457146794340554 no 1850 0.458400436500593 2574 16643986
SGTC_1175 0741-0056 27.6 µM -0.105075698582569 0.45690545027097 no 1851 0.458157871130527 2706 765927
SGTC_367 0335-0881 7.1 µM -0.105293587872323 0.456819439898523 no 1852 0.458071425415164 2695 23828853
SGTC_1183 1254-0324 198 µM -0.106254445895248 0.456440171659964 no 1853 0.457690236910146 2691 5799357
SGTC_520 3584-0023 682 µM -0.107391824647494 0.455991278772495 no 1854 0.457239069992757 2694 1340790
SGTC_129 0088-0017 176.636 µM -0.107617788985032 0.455902103378996 no 1855 0.457149442688258 2601 182446
SGTC_1988 st071872 53.4 µM -0.107632124994492 0.455896445838625 no 1856 0.457143756475575 2586 16414116
SGTC_3075 9116269 49.47 µM -0.108637435111076 0.455499734191461 no 1857 0.456745033768138 2722 17015205 YNL244C SUI1
SGTC_2625 euphol 100 µM -0.110371486065359 0.454815554100419 no 1858 0.45605738288498 2673 6708538 A triterpene alcohol.
SGTC_2972 9093619 59.92 µM -0.111197771868107 0.454489585155775 no 1859 0.455729759234174 2605 25236256
SGTC_249 wiskostatin 11.211 µM -0.112943031544436 0.453801182905689 no 1860 0.455037860166358 2590 2775510 A n-wasp and actin depolymerizer.
SGTC_2282 7944268 200 µM -0.114319962817665 0.453258162369162 no 1861 0.454492079100409 2696 2970414
SGTC_1161 k007-0610 110 µM -0.116649986170513 0.452339470384113 no 1862 0.453568712422493 2665 5843850
SGTC_3199 9111318 49.47 µM -0.117078507973182 0.452170538527293 no 1863 0.45339892037279 2698 8548020
SGTC_2639 lactacystin 53 µM -0.117368629604341 0.452056171697156 no 1864 0.453283971087498 2694 3870 A proteasome inhibitor.
SGTC_1026 k007-1105 30.6 µM -0.118136019339023 0.451753683530901 no 1865 0.452979941981994 2613 7066794
SGTC_3162 9099653 49.47 µM -0.119094602120745 0.451375870631998 no 1866 0.45260020359599 2620 25237511
SGTC_798 1287-0182 476 µM -0.120216509578393 0.450933741402811 no 1867 0.45215581993442 2614 1649755
SGTC_2589 lobaric acid 100 µM -0.120697470356375 0.450744219585484 no 1868 0.451965331355765 2675 73157 A novel microtubule depolymerizer.
SGTC_221 trifluoperazine 10.304 µM -0.120945150341309 0.450646626065437 no 1869 0.451867239916307 2630 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1
SGTC_2438 5259590 200 µM -0.121468092663558 0.450440580539389 no 1870 0.451660142952351 2732 1201127
SGTC_1848 st056003 16.4 µM -0.121916376365257 0.450263962032572 no 1871 0.45148262295685 2591 146492
SGTC_261 5-fluorouridine 15.376 µM -0.122184082084577 0.450158493822382 no 1872 0.451376616325761 2695 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_611 3453-1652 23.7 µM -0.125274417220073 0.44894124904596 no 1873 0.450153152356608 2629 1560575
SGTC_2606 farnesol 9.78 µM -0.126637925395307 0.448404332114766 no 1874 0.449613489227421 2736 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_621 3584-0052 32.1 µM -0.127043697235879 0.448244567062587 no 1875 0.449452906668368 2632 2273927
SGTC_803 4488-1585 147 µM -0.127860011125469 0.447923184233951 no 1876 0.449129878863879 2735 747204
SGTC_3091 9116372 49.47 µM -0.128579910213744 0.447639788275402 no 1877 0.448845031829868 2789 17169793
SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM -0.129893068700592 0.44712291836397 no 1878 0.448325514102447 2626 803109
SGTC_2875 9039966 71.43 µM -0.130928209411804 0.446715541768233 no 1879 0.447916049440139 2739 6463691
SGTC_1738 st035555 74 µM -0.131763357910432 0.446386912480206 no 1880 0.447585734972649 2732 5331140
SGTC_702 1488-0190 94 µM -0.132622539786099 0.446048864531642 no 1881 0.447245952856335 2716 949357
SGTC_3295 9122362 53.5725 µM -0.132817754773904 0.445972062007551 no 1882 0.447168756242078 2718 4730473
SGTC_2810 7959871 45.46 µM -0.135684630493573 0.444844395410905 no 1883 0.446035299217256 2753 2974535
SGTC_2979 9012552 45.46 µM -0.135847543735321 0.44478032787839 no 1884 0.4459709024747 2699 17100905
SGTC_3209 9113616 49.47 µM -0.136589619485303 0.444488516209291 no 1885 0.445677591022817 2710 16649353
SGTC_1742 st038235 28.8875 µM -0.136659334266169 0.444461103318999 no 1886 0.445650037216067 2772 564103 YBR002C RER2
SGTC_2519 cryptotanshinone 88.04 µM -0.137016460827602 0.444320680004331 no 1887 0.445508891981979 2707 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE)
SGTC_2734 clemastine 41.6 µM -0.137380700465008 0.444177467004423 no 1888 0.445364942598863 2633 26987 Clemastine is a selective histamine H1 antagonist.
SGTC_2415 st077333 57.7 µM -0.137573053566686 0.444101839886541 no 1889 0.445288926566234 2672 2766255
SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM -0.138253961184809 0.443834145054442 no 1890 0.445019854830181 2622 2333 A French combination drug.
SGTC_2959 9079155 11 µM -0.139862725284941 0.443201770906396 no 1891 0.444384226330198 2810 16189457
SGTC_1012 4112-3522 18 µM -0.142577645278459 0.442134917024907 no 1892 0.443311876782543 2656 3112398
SGTC_1996 st072960 66.8 µM -0.143536494316521 0.441758227945704 no 1893 0.442933245670042 2642 1719405
SGTC_2484 5809818 12.04 µM -0.143715781615131 0.441687799786056 no 1894 0.442862454323371 2715 2870548
SGTC_212 3807-4682 38.772 µM -0.145030798943507 0.441171287334141 no 1895 0.442343277412005 2736 3125501 YBL034C STU1
SGTC_1900 st060200 72.8 µM -0.145771069161775 0.440880567983427 no 1896 0.442051057685302 2643 688945
SGTC_3027 9089541 49.47 µM -0.146853189238688 0.440455654521881 no 1897 0.441623950402463 2761 9943819
SGTC_2968 9090663 33.37 µM -0.149061831169144 0.439588605738828 no 1898 0.440752421829751 2766 25236811
SGTC_303 1348-1668 34.2 µM -0.149146717625271 0.439555287532067 no 1899 0.440718931391343 2717 5380509
SGTC_703 3875-0075 71.8 µM -0.149324183962496 0.439485632808001 no 1900 0.440648916580922 2695 2850814
SGTC_3055 9094636 49.47 µM -0.149781328997845 0.439306214110336 no 1901 0.440468570234416 2819 25236176
SGTC_790 1575-0012 79.1 µM -0.150536867290561 0.439009710409838 no 1902 0.440170533117589 2761 378741 YLR208W SEC13
SGTC_2151 5563267 85.4165 µM -0.150956427346904 0.438845072887658 no 1903 0.440005043929954 2719 5310824
SGTC_63 0099-0242 26.702 µM -0.151309714915854 0.438706449234352 no 1904 0.439865703060786 2688 3898502 YLR359W ADE13
SGTC_697 0508-1955 564 µM -0.151997809015443 0.438436475150694 no 1905 0.439594331863048 2734 6243113
SGTC_494 Boc-Gly-Val-Val-CHO 140 µM -0.15271047755171 0.438156889473161 no 1906 0.439313298896836 2662 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA.
SGTC_3056 9094900 49.47 µM -0.154196526530246 0.43757399978197 no 1907 0.438727390432587 2728 25236784
SGTC_3246 9135460 32.98 µM -0.154469941668392 0.437466769805443 no 1908 0.438619604906523 2711 41446951
SGTC_542 3381-0244 89.3 µM -0.154620110292365 0.437407877514315 no 1909 0.43856040747196 2849 1112843
SGTC_644 1498-1197 63.3 µM -0.155242831353041 0.437163677063992 no 1910 0.438314941518897 2781 6741615
SGTC_986 1493-0483 84 µM -0.155464640075077 0.437076700413004 no 1911 0.438227514054504 2671 40079
SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM -0.156449818385156 0.4366904245948 no 1912 0.437839235599828 2752 279621
SGTC_1760 st045453 10.4495 µM -0.159671375997812 0.435427716343319 no 1913 0.436569975106436 2734 3323419 YIL048W NEO1
SGTC_1681 tripelennamine 100 µM -0.16061114451068 0.435059492022808 no 1914 0.436199838404775 2666 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist.
SGTC_3273 9137859 49.47 µM -0.162379198760368 0.434366877941858 no 1915 0.435503625214255 2691 2377234
SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM -0.167455551808863 0.432379403905078 no 1916 0.433505809078441 2709 6708561
SGTC_1785 bathophenanthroline 24 µM -0.168065059266165 0.432140885895011 no 1917 0.433266048490394 2718 72812 An iron chelator.
SGTC_1036 k216-0215 33.5 µM -0.16822515228286 0.432078240934992 no 1918 0.433203077126725 2694 622330
SGTC_3257 9139206 32.98 µM -0.168587737775982 0.431936366273558 no 1919 0.43306046316868 2813 4910041
SGTC_2122 5258151 111.688 µM -0.168753539350689 0.431871493346541 no 1920 0.432995252159065 2742 2173356
SGTC_2885 9057732 51.95 µM -0.16939678363567 0.431619829550022 no 1921 0.432742276617233 2846 6471414
SGTC_2776 terbinafine 19.92 µM -0.169842270907103 0.431445552744301 no 1922 0.432567091234728 2675 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_2424 5537928 59.2 µM -0.169953094041445 0.431402200261973 no 1923 0.432523512713296 2728 5382802
SGTC_2046 4110841 106 µM -0.171135676740937 0.430939641770818 no 1924 0.432058541837657 2790 44119630 YMR134W ERG29
SGTC_1019 4262-0212 3.4 µM -0.171482615874708 0.430803957031744 no 1925 0.431922149249121 2751 4677213
SGTC_2210 7115885 190.385 µM -0.172228496813763 0.430512277457156 no 1926 0.431628947696181 2719 2927039
SGTC_2598 perillyl alcohol 100 µM -0.172287127651407 0.430489351250297 no 1927 0.431605901842086 2859 10819 An apoptosis inducer.
SGTC_3188 9110789 49.47 µM -0.173446321324726 0.430036124097996 no 1928 0.431150308830079 2856 849217
SGTC_987 1497-1013 404 µM -0.17371604215847 0.429930680537756 no 1929 0.431044314698986 2696 1676435
SGTC_1405 3909-7894 12 µM -0.174467885257051 0.429636784473548 no 1930 0.430748883761713 2821 7104060
SGTC_23 0213-0011 39.996 µM -0.174492702924081 0.429627083891676 no 1931 0.430739132510951 2844 627608
SGTC_1583 clindamycin 39.6 µM -0.174499191562794 0.42962454765823 no 1932 0.430736583029958 2712 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis.
SGTC_970 1315-0089 19.5 µM -0.174860843716756 0.429483192204283 no 1933 0.430594489179723 2723 6811083 YLR033W RSC58
SGTC_3177 9107506 49.47 µM -0.175046987158311 0.429410439653908 no 1934 0.430521356553029 2801 8897194
SGTC_3285 9112818 20.8695 µM -0.176261232999907 0.42893592113131 no 1935 0.430044358370526 2696 17017947 YPR165W RHO1
SGTC_1224 0823-0416 294 µM -0.176521587725457 0.428834189727973 no 1936 0.429942095206575 2842 3598164
SGTC_2349 9023730 187.07 µM -0.176887015698736 0.428691409819419 no 1937 0.429798568883775 2842 4126287
SGTC_1710 st031758 61.5 µM -0.177604396795423 0.428411142050638 no 1938 0.429516835650807 2886 5394341
SGTC_609 0986-0026 86.3 µM -0.177925171225384 0.42828583297767 no 1939 0.429390871232946 2733 2848610
SGTC_2308 7584454 197.62 µM -0.178007011370505 0.428253863654217 no 1940 0.429358734702713 2848 893577
SGTC_2439 5492030 7.2 µM -0.179054473969028 0.427844733614089 no 1941 0.428947464364619 2832 5722370
SGTC_1420 4'-methoxyflavone 42 µM -0.179388091005338 0.427714441884371 no 1942 0.428816490857697 2731 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13
SGTC_1188 1403-0014 4.57 µM -0.179825785940767 0.427543515237434 no 1943 0.428644669674035 2749 9614867
SGTC_441 propafenone 146 µM -0.180010292998956 0.427471466448009 no 1944 0.428572243776696 2709 4932 Slows the influx of sodium ions into the cardiac muscle.
SGTC_1507 4075-3230 155 µM -0.180350195599843 0.427338743058093 no 1945 0.428438825636127 2680 659771
SGTC_280 3448-3607 3.04 µM -0.181271423115727 0.426979068344895 no 1946 0.428077267735924 2782 626179
SGTC_698 k064-0052 127 µM -0.182465527899771 0.42651294457669 no 1947 0.427608702476165 2691 5088751
SGTC_2316 5844804 197.44 µM -0.182821764151373 0.426373906119382 no 1948 0.427468935546135 2847 776813
SGTC_2740 felodipine 17.08 µM -0.183573421351798 0.426080565520207 no 1949 0.427174057716253 2835 3333 L-type calcium channel blocker
SGTC_1213 1315-0166 115 µM -0.186124311703324 0.425085364752364 no 1950 0.42617363851952 2860 768401
SGTC_1887 st057648 70.8 µM -0.186479321454748 0.424946899433627 no 1951 0.426034446761545 2882 688672
SGTC_1450 4112-4260 37.6 µM -0.186696649280776 0.424862139099822 no 1952 0.425949241698342 2784 1633175
SGTC_1099 5-nonyloxytryptamine 2.85 µM -0.188836611736738 0.42402771541141 no 1953 0.425110438012784 2745 23581825 A 5-HT1D beta serotonin receptor agonist.
SGTC_1756 st041558 35.5 µM -0.188887039982763 0.424008056296776 no 1954 0.425090675664468 2896 3955792
SGTC_820 1582-0060 59.9 µM -0.190814561142742 0.423256767254431 no 1955 0.424335440076477 2790 3848840
SGTC_2088 5278280 127.392 µM -0.191604573890108 0.42294892478804 no 1956 0.424025979726613 2830 791502
SGTC_2947 9072639 7.68 µM -0.19371032090621 0.422128613444684 no 1957 0.423201355002446 2822 16488146
SGTC_765 1319-0117 244 µM -0.19511308927089 0.421582340494677 no 1958 0.42265220787417 2747 3487746 YGL099W LSG1
SGTC_169 k015-0017 16.025 µM -0.195250927479845 0.421528670986408 no 1959 0.422598255912263 2898 1840002
SGTC_131 0141-0277 33.849 µM -0.199845213586894 0.419740652316956 no 1960 0.420800819593529 2925 1547771
SGTC_1746 st038117 42 µM -0.199973291644084 0.419690830047652 no 1961 0.420750734696239 2868 2898218
SGTC_1368 1852-0141 284 µM -0.200325724090054 0.419553740734321 no 1962 0.420612922686205 2890 2838987
SGTC_124 0136-0217 7.121 µM -0.200778668248982 0.419377568673835 no 1963 0.420435821770504 2856 3976905
SGTC_156 3474-0145 5.642 µM -0.200932851170489 0.419317603105642 no 1964 0.420375540005871 2689 2265471
SGTC_2842 9000675 19.48 µM -0.201239880240432 0.419198197456005 no 1965 0.420255504685817 2823 2989072
SGTC_1933 st074711 15.9 µM -0.202141821254645 0.418847469669006 no 1966 0.419902927008865 2709 17250958
SGTC_230 MPP+ 141.667 µM -0.203043894214235 0.418496755076617 no 1967 0.419550362043375 2798 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death.
SGTC_2421 5690543 90.72 µM -0.203379493866514 0.418366294681622 no 1968 0.419419213197731 2851 3397993
SGTC_2873 9040596 71.43 µM -0.203545049067612 0.418301940362233 no 1969 0.419354519247104 2864 6463863
SGTC_824 1304-0008 100 µM -0.203669630822653 0.418253514608908 no 1970 0.419305837913692 2782 768245
SGTC_1792 st045773 43.6 µM -0.203710065575267 0.418237797619073 no 1971 0.419290037970919 2755 2919270
SGTC_1018 4259-0013 28.1 µM -0.203977436267425 0.418133873908121 no 1972 0.419185565731753 2916 6801262
SGTC_2408 sulbentine 18.36 µM -0.206957185136548 0.416976070439268 no 1973 0.418021647930383 2856 67686 An antifungal agent of unknown mechanism. YDL205C HEM3
SGTC_2549 cedrol 20.94 µM -0.207621243382762 0.416718143406197 no 1974 0.417762357987573 2943 6708665 A sedative which affects the nervous system.
SGTC_737 1950-0117 57.9 µM -0.208269201586787 0.416466504348117 no 1975 0.417509388966067 2835 5393513
SGTC_914 3820-6779 408 µM -0.208448841731382 0.416396745909538 no 1976 0.417439261791187 2749 2893481
SGTC_682 0kpi-0099 17 µM -0.208518046999779 0.416369872599667 no 1977 0.417412246425978 2857 1714895 YML126C ERG13
SGTC_736 0958-0254 92.6 µM -0.208733952533013 0.416286036173091 no 1978 0.417327966810463 2882 6812352
SGTC_2808 7946468 45.46 µM -0.208898363875522 0.416222197568348 no 1979 0.417263790711868 2852 2970879
SGTC_1447 4239-0816 81.9 µM -0.210000116492336 0.415794459679457 no 1980 0.41683379105737 2780 1341554
SGTC_1199 1638-0010 4.46 µM -0.21003323848956 0.415781602133899 no 1981 0.416820865512256 2769 3111136
SGTC_142 0335-0849 62.6745 µM -0.210239656253757 0.415701475368613 no 1982 0.416740314965403 2793 3889043 YPR107C YTH1
SGTC_3121 9125696 49.47 µM -0.212497762979053 0.414825158353358 no 1983 0.415859361409449 2767 1235365
SGTC_3289 9119912 71.43 µM -0.214101472261227 0.414203054302634 no 1984 0.415233963859437 2891 17014829
SGTC_1498 4478-3555 97.6 µM -0.214197384347258 0.414165855300799 no 1985 0.415196567869453 2803 3437919
SGTC_1616 st002734 56.1 µM -0.21576485773913 0.413558028285405 no 1986 0.414585521268991 2807 4026101
SGTC_1390 3413-2614 145 µM -0.217364436935028 0.412937964926195 no 1987 0.413962171920873 2845 3421432
SGTC_164 4100-3994 89.624 µM -0.218122507049083 0.412644181196717 no 1988 0.413666830745635 2832 4615967
SGTC_2055 5235184 200 µM -0.220274051714651 0.411810635090689 no 1989 0.412828863802307 2960 2836034
SGTC_2084 5306078 60.6385 µM -0.220529279058885 0.411711781865008 no 1990 0.412729486105415 2862 679340
SGTC_58 0957-0393 9 µM -0.222109697465441 0.411099788064829 no 1991 0.412114244456856 2835 6997992
SGTC_2279 7948423 32.93 µM -0.22323818981163 0.410662928263797 no 1992 0.411675065319445 2993 1247112
SGTC_1234 0326-0494 15.5 µM -0.223438110116237 0.410585547035692 no 1993 0.411597273186216 2945 1547813
SGTC_2565 isoliquiritigenin 100 µM -0.223690019498772 0.410488047851526 no 1994 0.411499256233709 2940 638278 Binds to benzodiazepine receptor 65X better than valium.
SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM -0.22434053905564 0.410236295906216 no 1995 0.411246167187213 2954 5393153
SGTC_3000 9075062 71.4286 µM -0.226641697018416 0.409346042194109 no 1996 0.410351183159024 2848 17057871
SGTC_2414 st077232 92.9 µM -0.228321687304964 0.408696395739618 no 1997 0.409698082878972 2781 729801
SGTC_597 k018-0003 82.8 µM -0.228789715716059 0.408515455354826 no 1998 0.409516180237798 2929 6786234
SGTC_2780 5215298 71.43 µM -0.228792476610187 0.408514388047429 no 1999 0.409515107253993 2950 2834131
SGTC_3013 9080133 71.4286 µM -0.22908593349885 0.40840094725366 no 2000 0.409401063107307 3014 17050193
SGTC_2332 7982454 138.89 µM -0.231597024307773 0.407430556815142 no 2001 0.408425509470465 2879 2981748
SGTC_2103 5378138 10 µM -0.232209797438143 0.407193841623516 no 2002 0.408187534232485 2812 244142
SGTC_203 k066-0004 30.888 µM -0.232468935179756 0.407093746512036 no 2003 0.408086906245983 2800 6795412
SGTC_1005 4092-0690 4.4 µM -0.232670378119559 0.407015940912203 no 2004 0.40800868640732 2876 1529343
SGTC_1045 1348-1485 165 µM -0.232798772089222 0.406966351762217 no 2005 0.407958833231603 2813 6810614
SGTC_716 1683-5115 658 µM -0.235937564919565 0.405754532633931 no 2006 0.406740559190466 2790 723597
SGTC_521 r062-0005 13.8 µM -0.236275801067883 0.405624000737473 no 2007 0.406609331672566 2793 2832033
SGTC_439 amiodarone 34.4 µM -0.236998171121224 0.40534525926513 no 2008 0.406329104540154 2885 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1
SGTC_630 4356-0227 183 µM -0.237353533802674 0.405208152808138 no 2009 0.406191267216572 2836 779312
SGTC_1358 1509-0022 2.48 µM -0.237731218484113 0.405062446802199 no 2010 0.406044784427273 2881 3258434
SGTC_1572 epiandrosterone 68.9 µM -0.237972628107106 0.404969320894537 no 2011 0.405951162008938 2807 441302 A steroid.
SGTC_2287 7945887 168.79 µM -0.238515459359285 0.404759938576826 no 2012 0.405740663231504 2927 1245853
SGTC_2116 5511452 16.8835 µM -0.239430554560586 0.404407027372507 no 2013 0.40538586988769 2954 870744
SGTC_2097 5376186 200 µM -0.239576538515677 0.404350735089179 no 2014 0.405329277345642 2954 742755
SGTC_491 tetrandrine 80.3 µM -0.241272573189794 0.403696879438195 no 2015 0.404671933242055 2935 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_284 0988-0104 32.6 µM -0.241571260629736 0.403581757203473 no 2016 0.404556196648068 2925 4666532
SGTC_96 0929-0093 37.281 µM -0.244763934978072 0.402351737755543 no 2017 0.403319610166474 2836 6991579
SGTC_2916 7875993 68.79 µM -0.245493388094104 0.402070841583271 no 2018 0.403037213553207 2850 1299250
SGTC_298 1391-0729 10 µM -0.247363232743349 0.401351037280229 no 2019 0.402313563079275 2850 3237558
SGTC_2369 9071472 200 µM -0.247395090158298 0.401338776531259 no 2020 0.402301236801286 2985 17296037
SGTC_3003 9075612 71.4286 µM -0.247693505629964 0.401223932094779 no 2021 0.402185778540134 2908 6501993
SGTC_2203 7227154 166.4 µM -0.247751803933226 0.401201497136894 no 2022 0.402163223665803 2835 896304
SGTC_2109 5483026 200 µM -0.248153934358134 0.401046754011666 no 2023 0.402007653380677 2883 759335
SGTC_50 0929-0078 56.389 µM -0.249185410249439 0.400649904554137 no 2024 0.401608682241246 2863 1377751
SGTC_3274 9138298 49.47 µM -0.249272310855541 0.400616475140486 no 2025 0.401575074079016 2823 17015756
SGTC_749 1000-0129 128 µM -0.249321698321529 0.400597476816825 no 2026 0.401555974168777 3004 708470
SGTC_683 panaxydol 45 µM -0.249400752810154 0.400567066700453 no 2027 0.401525401442901 2882 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis.
SGTC_2137 5261020 140 µM -0.252760034128646 0.399275401521841 no 2028 0.400226826582326 2838 763655
SGTC_2997 9067075 71.4286 µM -0.253505558371986 0.398988891589841 no 2029 0.399938783231619 2956 27209819
SGTC_1767 st044992 70.3 µM -0.254865352519617 0.398466453877051 no 2030 0.399413548706641 2906 9600693
SGTC_2669 eugenol 100 µM -0.255499593822735 0.398222838285717 no 2031 0.3991686286421 2928 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism.
SGTC_1218 1348-1416 30.7 µM -0.255772891967503 0.398117875180496 no 2032 0.39906310343817 2840 6787668
SGTC_315 k915-0449 187 µM -0.257262695745701 0.397545829763315 no 2033 0.398487993977592 2899 20970215 YNL149C PGA2
SGTC_3070 9117005 49.47 µM -0.259989352849186 0.396499436508007 no 2034 0.397435993232921 2876 8779016
SGTC_2161 5662504 8.5105 µM -0.260289251581917 0.396384391467509 no 2035 0.397320331469972 2888 2859334
SGTC_939 1165-0479 45.3 µM -0.26062219906191 0.396256679066915 no 2036 0.397191934392501 2976 1377347
SGTC_825 1988-2224 89.6 µM -0.261920300018261 0.395758858348444 no 2037 0.396691444331164 2857 1180859
SGTC_2720 fluspirilene 36.88 µM -0.262394072769526 0.395577209164803 no 2038 0.396508820943399 2960 3396 An atypical antipsychotic.
SGTC_2171 5739187 198.077 µM -0.264843642913414 0.394638382246187 no 2039 0.395564957385363 2817 2262761
SGTC_1335 1486-0900 202 µM -0.265175762643292 0.394511140366982 no 2040 0.395437032670301 2837 X1335
SGTC_958 1222-0007 33 µM -0.266218290774922 0.394111799630142 no 2041 0.395035548579662 3055 7312461
SGTC_335 4077-0256 27.6 µM -0.26627452661634 0.394090261632915 no 2042 0.395013894969474 2962 3121989
SGTC_1733 st037357 54.9 µM -0.266465862237853 0.394016983638845 no 2043 0.394940223619006 2830 1272339 YGL099W LSG1
SGTC_2221 6807166 181.081 µM -0.266676327368941 0.393936383730784 no 2044 0.394859191032027 2943 674925
SGTC_377 3970-0964 33.1 µM -0.267159434624813 0.393751389746874 no 2045 0.394673203884685 2857 16481235
SGTC_896 0964-0007 44.5 µM -0.267195678424417 0.393737512045901 no 2046 0.394659251675439 2937 6756758
SGTC_2427 5545055 42.75 µM -0.268444688449306 0.393259350405119 no 2047 0.394178522475558 2901 5372858
SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM -0.269207979789464 0.39296721686335 no 2048 0.393884819949555 2859 364106
SGTC_1560 lithocholic acid 53.1 µM -0.269982651925021 0.392670789189294 no 2049 0.393586799974278 2903 9903 A bile acid which acts as a detergent.
SGTC_3254 9136651 49.47 µM -0.27018322431445 0.392594050462201 no 2050 0.393509648993247 2906 16454030
SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM -0.270405063491758 0.39250917995365 no 2051 0.393424322525576 2918 4330530
SGTC_1154 4088-0362 150 µM -0.270627367775629 0.392424136633833 no 2052 0.393338822297381 2859 6618304
SGTC_940 3232-1287 54.8 µM -0.271486581717573 0.39209548951696 no 2053 0.393008409277664 2885 1585493 YIL048W NEO1
SGTC_470 aa-861 153 µM -0.271598087329896 0.392052844544962 no 2054 0.392965535140922 2903 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor.
SGTC_2234 tolnaftate 200 µM -0.271644222851535 0.392035200538491 no 2055 0.392947796317903 2922 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7
SGTC_1104 tacrolimus 29.8 µM -0.272916843549574 0.391548588844642 no 2056 0.392458569288288 2912 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41
SGTC_3050 9093513 49.47 µM -0.273684756274636 0.391255044247518 no 2057 0.392163446686911 2891 25236664
SGTC_867 0518-0118 155 µM -0.273873229816265 0.391183007250881 no 2058 0.392091022404815 2958 6848158
SGTC_1231 0242-0792 125 µM -0.273994127198057 0.39113680069128 no 2059 0.39204456742175 2867 3707635
SGTC_3299 9121982 43.1275 µM -0.274757639683006 0.390845024388618 no 2060 0.391751222284562 2916 17594604 YPL160W CDC60
SGTC_1109 tnp00067 928.257 nM -0.275951612537762 0.390388870870176 no 2061 0.391292615627751 2919 676295
SGTC_1974 st069448 26.9 µM -0.276009125031524 0.390366902208571 no 2062 0.391270528806841 3038 6323587 YNR016C ACC1
SGTC_412 gemfibrozil 100 µM -0.277400501455712 0.389835530121763 no 2063 0.390736298311596 2936 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels.
SGTC_2028 5153890 36.43 µM -0.277643953776524 0.389742575860351 no 2064 0.390642843942445 2898 2830968 YPR165W RHO1
SGTC_1326 1431-2094 10.8 µM -0.277651615734243 0.389739650496133 no 2065 0.390639902838952 2841 616278
SGTC_1803 st050068 52.4 µM -0.277718694012528 0.389714040024428 no 2066 0.39061415457478 2919 3984059 YIL048W | YNL267W NEO1 | PIK1
SGTC_3158 9100007 49.47 µM -0.277805023710652 0.389681080069659 no 2067 0.390581017282378 2920 19297233
SGTC_154 3389-1638 511.116 µM -0.278314829535073 0.389486456665235 no 2068 0.390385346666915 2984 5238686
SGTC_220 paclitaxel 373.376 µM -0.279231130155847 0.389136719562376 no 2069 0.390033727475703 3000 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_338 4055-0136 114 µM -0.279600648476658 0.388995705798631 no 2070 0.389891954762527 2896 2900563
SGTC_485 niflumic acid 177 µM -0.279945494899846 0.388864120392141 no 2071 0.389759661103113 3009 4488 A COX2 inhibitor.
SGTC_144 4161-2749 112.381 µM -0.280840379482846 0.388522712666107 no 2072 0.389416415550161 2911 797501 YMR168C CEP3
SGTC_330 1488-0319 80.1 µM -0.281219449555912 0.388378119456917 no 2073 0.389271043890642 2960 6846614
SGTC_747 3448-8087 38.7 µM -0.281699442011606 0.388195052417665 no 2074 0.389086991189726 2947 5168703
SGTC_938 3126-1755 342 µM -0.28375205916847 0.387412473839985 no 2075 0.388300198102901 3086 1777771
SGTC_2015 5119600 184 µM -0.285352112403098 0.386802756263616 no 2076 0.387687195854795 3097 2828786
SGTC_693 4161-2696 114 µM -0.285689961868532 0.386674050733319 no 2077 0.387557796841237 3009 805759
SGTC_201 4262-0159 12.803 µM -0.288351339279334 0.385660621879015 no 2078 0.386538906044472 2983 1341029
SGTC_2075 5212009 200 µM -0.289086219649843 0.385380923104078 no 2079 0.38625769936753 3063 780898
SGTC_228 caffeine 993.056 µM -0.28961489837818 0.385179742457323 no 2080 0.386055434004902 3048 2519 Caffeine is a phosphodiesterase inhibitor.
SGTC_3221 9128209 49.47 µM -0.290288229014395 0.384923561470989 no 2081 0.385797871612603 2950 16460723
SGTC_686 1319-0111 510 µM -0.290814475782483 0.384723376200473 no 2082 0.385596606772018 3081 4562600
SGTC_2374 9071832 200 µM -0.291888094927641 0.384315064788926 no 2083 0.385186093099289 2889 17381698
SGTC_3355 9151058 44.0485 µM -0.293358638371852 0.383756006220719 no 2084 0.384624018562721 2945 17015728
SGTC_2196 6573537 42.6665 µM -0.293974258606115 0.383522036763888 no 2085 0.384388786687326 3036 2903087
SGTC_1911 st060208 74.3 µM -0.29402073044181 0.383504376640066 no 2086 0.384371031270398 3035 688783
SGTC_1239 0337-0584 35.4 µM -0.296084145258289 0.382720486767403 no 2087 0.383582910845583 3101 914301 YML130C ERO1
SGTC_2141 5621638 7.665 µM -0.297171817469451 0.382307473906373 no 2088 0.383167668444921 3048 2856238
SGTC_2395 5646831 180.19 µM -0.2973955429383 0.382222537049968 no 2089 0.383082273032011 3103 6808628
SGTC_899 1083-0020 478 µM -0.298468012584857 0.381815455195274 no 2090 0.382672993203312 3101 767123
SGTC_2333 9017922 200 µM -0.299323707343624 0.381490749190894 no 2091 0.382346533737382 3066 3163164
SGTC_1034 k072-0165 12.7 µM -0.300251458296162 0.381138794621254 no 2092 0.38199267829906 3092 5835461
SGTC_1855 st056195 39.6 µM -0.301193568340375 0.380781493329138 no 2093 0.381633446986507 3117 4028379
SGTC_3227 9130768 49.47 µM -0.301645872550613 0.380609990145386 no 2094 0.381461017303252 2932 17720899
SGTC_2242 6630449 61.2675 µM -0.301706950764081 0.38058683251176 no 2095 0.381437734561965 3082 691249 YDR170C SEC7
SGTC_2794 7785382 27.27 µM -0.302712526941958 0.380205632688097 no 2096 0.381054475166413 3003 2205081
SGTC_2600 tangeritin 87.95 µM -0.304125752189978 0.379670095516691 no 2097 0.380516044042247 2919 68077 A bioactive flavone.
SGTC_1699 st031318 29.054 µM -0.305203114650883 0.379261987403041 no 2098 0.380105730181129 3049 5340658
SGTC_2677 mitomycin C 100 µM -0.305248344643235 0.379244857086084 no 2099 0.380088507270546 2967 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_184 1494-0393 24.714 µM -0.306196501665249 0.378885808620152 no 2100 0.379727517920586 2913 3090647
SGTC_1782 st039423 80.636 µM -0.306211499992893 0.378880129886363 no 2101 0.379721808487546 2987 2068169
SGTC_1688 st021091 57.6 µM -0.306858456447577 0.378635201247311 no 2102 0.379475555701626 3070 3656366
SGTC_2340 7987427 183.45 µM -0.306996896703577 0.378582796035797 no 2103 0.37942286715846 3067 2239331
SGTC_1298 1079-1278 263 µM -0.307068354383934 0.37855574729995 no 2104 0.379395672179985 2964 2840950
SGTC_678 1218-2179 85.9 µM -0.307842249649817 0.378262844379972 no 2105 0.379101185547397 2998 6820081 YOR116C RPO31
SGTC_3051 9093778 49.47 µM -0.308000562775275 0.378202934836828 no 2106 0.379040952055092 2989 17217378
SGTC_1247 0448-0043 5.84 µM -0.308823205911822 0.377891673806035 no 2107 0.378728007826962 3067 3089013 YGL099W LSG1
SGTC_1528 arabinosylhypoxanthine 74.6 µM -0.309969849258514 0.377457954047261 no 2108 0.378291942338083 3178 804 An inhibitor of viral and cellular DNA polymerases.
SGTC_1964 st076914 61 µM -0.310293574153323 0.377335532508502 no 2109 0.378168858628629 2917 24208661
SGTC_2884 9058502 51.95 µM -0.310641287711026 0.377204053018019 no 2110 0.378036667941424 3059 6471554
SGTC_2984 9022109 38.96 µM -0.311061071148021 0.377045341008131 no 2111 0.37787709738501 3062 6459207
SGTC_116 0155-0182 31.788 µM -0.311092928033149 0.377033297382773 no 2112 0.37786498860816 2966 771486
SGTC_2679 rapamycin 1 nM -0.311211226439961 0.376988575234618 no 2113 0.377820024527556 3027 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2
SGTC_44 0929-0055 61.211 µM -0.313587676612678 0.376090519893949 no 2114 0.37691711019874 2940 1379590
SGTC_3022 9087993 49.47 µM -0.314418268779143 0.375776798815279 no 2115 0.376601691358421 3033 17173644
SGTC_1061 3448-9325 110 µM -0.31453190487592 0.375733883963555 no 2116 0.376558544250763 2987 723482
SGTC_1387 3342-1166 1.8 µM -0.314877447549016 0.375603398672225 no 2117 0.376427352750162 3016 3418228
SGTC_2254 7938975 95.19 µM -0.315615982434577 0.375324557710536 no 2118 0.37614700254905 3153 2969277
SGTC_2768 sulfasalazine 50.2 µM -0.315676759064154 0.375301613806921 no 2119 0.376123934454278 3087 5384001 An antioxidant and salicylic acid derivative.
SGTC_1564 D-Arginine 115 µM -0.316080542569145 0.375149191915328 no 2120 0.375970687506921 2997 71070 D-isomer of arginine; arginine decarboxylase inhibitor.
SGTC_1992 st073643 23.3 µM -0.317084445322853 0.374770319019572 no 2121 0.375589763602985 2924 3161292
SGTC_1270 0831-1170 17.3 µM -0.318793761934981 0.374125501146736 no 2122 0.374941454464509 2956 6764716
SGTC_1491 4138-0063 26.5 µM -0.318842314519664 0.374107190437052 no 2123 0.374923044603843 3063 23883227
SGTC_1768 st044301 37.178 µM -0.319586674439414 0.373826504434344 no 2124 0.374640838637829 3010 3931349
SGTC_1408 3909-7976 48.8 µM -0.321594867861051 0.373069581486507 no 2125 0.373879816158634 3007 24152374
SGTC_2903 5923464 63.88 µM -0.32241907041079 0.372759066801392 no 2126 0.37356761943617 3065 2876576
SGTC_2379 9035213 200 µM -0.323297212872898 0.372428321448521 no 2127 0.373235082285165 3131 646551
SGTC_1926 methyl fluorone black 53.6 µM -0.323447752636036 0.372371631285921 no 2128 0.37317808498844 2991 72721 Reacts with homocysteine.
SGTC_1727 st034309 9.9045 µM -0.324771026217399 0.371873432931001 no 2129 0.372677187290396 3219 870305
SGTC_3028 9087778 49.47 µM -0.325833949501846 0.371473408952788 no 2130 0.372274995615896 2974 17217395
SGTC_1788 fluconazole 20 µM -0.325951984016889 0.371428996015559 no 2131 0.372230341993378 3076 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11
SGTC_1343 1487-0095 224 µM -0.326077855910896 0.371381635987741 no 2132 0.37218272530587 3118 4560101 YGL055W OLE1
SGTC_2823 7987624 58.44 µM -0.327398890369301 0.37088470672108 no 2133 0.371683102808063 3218 2239440
SGTC_1419 3993-2473 62.6 µM -0.327529291042817 0.370835665980637 no 2134 0.3716337962589 3017 704026
SGTC_1586 deoxycorticosterone acetate 53.7 µM -0.328081177486233 0.370628137225298 no 2135 0.371425142624334 3097 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE.
SGTC_1279 0874-0590 65.2 µM -0.328162292864001 0.370597638155186 no 2136 0.371394478233059 3024 3523074
SGTC_2304 7443016 91.4 µM -0.328549727295151 0.370451975520291 no 2137 0.371248026010253 2914 939854
SGTC_217 ketoconazole 989 nM -0.329031299122517 0.37027094620363 no 2138 0.371066015351184 3064 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4
SGTC_1922 5578187 25 µM -0.329456912128657 0.37011097647441 no 2139 0.370905178401551 3188 1350412
SGTC_2521 angolensin 13.4 µM -0.330545592339453 0.369701890429198 no 2140 0.370493874469453 3145 821428 A flavenoid.
SGTC_1552 6-methylflavone 10.6 µM -0.330742427337557 0.369627942789391 no 2141 0.370419525892012 3053 689013
SGTC_3225 9130819 49.47 µM -0.330752629106305 0.369624110285707 no 2142 0.370415672608616 3119 4547121
SGTC_2102 5377816 72.7585 µM -0.33162730865013 0.369295567173716 no 2143 0.370085348069083 3176 1379702
SGTC_568 1193-0097 7.48 µM -0.332370214657933 0.36901659517587 no 2144 0.369804863309472 3081 3646150
SGTC_1195 1502-0147 41.1 µM -0.334073276711783 0.368377331183056 no 2145 0.369162132421179 3003 817940
SGTC_3072 9116419 49.47 µM -0.336311158308481 0.367537870400225 no 2146 0.368318118193539 3055 17170162
SGTC_1435 4092-0789 56.7 µM -0.338376995625937 0.366763507153 no 2147 0.367539553802213 3102 2248285
SGTC_1876 myriocin 605 nM -0.338381755003923 0.366761723761226 no 2148 0.367537760734157 3181 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1
SGTC_1509 1326-1131 80 µM -0.342917890572642 0.365063296146273 no 2149 0.365830116104751 3123 768313
SGTC_1254 0550-0035 264 µM -0.3430228624344 0.365024023575308 no 2150 0.365790630370132 3144 15121435
SGTC_729 4092-0585 94.1 µM -0.343469143292617 0.36485707467256 no 2151 0.365622775282928 2993 2169061
SGTC_3242 9133940 49.47 µM -0.344396300919389 0.364510316839778 no 2152 0.365274135179685 3155 17248444
SGTC_294 k038-0071 157 µM -0.346316697738803 0.363792439436977 no 2153 0.364552360583797 3070 24152826
SGTC_2470 5664817 21.68 µM -0.346661230498914 0.363663697641956 no 2154 0.364422919821574 2994 2859561
SGTC_2319 6033012 152.6 µM -0.346887335184255 0.363579217312216 no 2155 0.36433798082047 3017 847246
SGTC_1201 1889-3372 45.9 µM -0.34727900693694 0.363432891246008 no 2156 0.364190860284884 3021 5392199
SGTC_2646 retinol 96.75 µM -0.347289801975215 0.363428858570665 no 2157 0.364186805714042 3098 445354 A vitamin A analog and teratogen.
SGTC_510 ag-490 170 µM -0.347352969934844 0.363405261378008 no 2158 0.364163080399582 3094 5328779
SGTC_70 0141-0289 43.283 µM -0.347514327422926 0.363344986594588 no 2159 0.36410247834951 3073 352408
SGTC_29 0299-0004 12.984 µM -0.349711293401447 0.362524651338355 no 2160 0.363277688660707 3053 16871 A napthoquinone isolated from Swertia calycina.
SGTC_2313 7726885 200 µM -0.350444047728352 0.362251184902553 no 2161 0.363002737153676 3110 726423
SGTC_601 0986-0029 62.9 µM -0.351304369452441 0.361930199587442 no 2162 0.362680008624884 3037 24747981
SGTC_2759 disulfiram 3.38 µM -0.352785175057699 0.361377939752548 no 2163 0.362124749346754 2996 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_3307 9126885 69.2785 µM -0.353023453721237 0.361289101726757 no 2164 0.362035428797064 3016 24824909
SGTC_1877 wortmannin 25 µM -0.353861153037995 0.360976839608194 no 2165 0.361721470572005 3168 312145 A covalent inhibitor of PI 3-kinase.
SGTC_302 1094-0063 18.9 µM -0.354204815479421 0.360848762239784 no 2166 0.361592697504807 3005 5440289
SGTC_2168 5727979 200 µM -0.354993697963872 0.360554817686563 no 2167 0.361297156232925 3025 695210
SGTC_1283 0922-0125 16.4 µM -0.355136758591383 0.360501520857663 no 2168 0.361243569885849 3119 3360884
SGTC_3067 9117431 49.47 µM -0.355143822666992 0.36049888922664 no 2169 0.361240923959262 3055 17150885
SGTC_59 0330-0160 1.33 µM -0.356435882914415 0.360017659955879 no 2170 0.360757080457601 3070 4293482
SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM -0.356490898493139 0.359997174259838 no 2171 0.360736483470932 3152 521171
SGTC_777 1315-0167 517 µM -0.357690188112803 0.359550704716923 no 2172 0.360287588356045 3106 4221767
SGTC_1596 piperlongumine 63 µM -0.358488207649586 0.359253725479757 no 2173 0.359988995611617 3187 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_2153 5569715 200 µM -0.358649100937651 0.359193860087797 no 2174 0.35992880495924 3086 2054701
SGTC_277 nystatin 15.5 µM -0.359341715456508 0.358936190631016 no 2175 0.359669735504075 2988 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_3102 9121669 49.47 µM -0.360432383164978 0.358530565826466 no 2176 0.359261906718239 3058 41905072
SGTC_1143 3454-2408 5.08 µM -0.361213629387679 0.358240114470321 no 2177 0.358969877111566 3071 X1143
SGTC_2987 9018338 71.43 µM -0.361336732554353 0.358194354707828 no 2178 0.358923868695151 3170 5055682
SGTC_2113 5491891 107.031 µM -0.361625915212548 0.358086868087814 no 2179 0.358815797998266 3062 789979
SGTC_1412 3909-8563 178 µM -0.363375279752199 0.357436884954342 no 2180 0.358162282730915 3157 23767530
SGTC_2074 5212007 75.395 µM -0.363552528498179 0.357371050531313 no 2181 0.3580960905362 3152 758611
SGTC_1667 st014849 34.6 µM -0.363654653364866 0.357333120840897 no 2182 0.358057954718847 3040 5348460
SGTC_2988 9073640 71.4286 µM -0.364360701258286 0.357070929668633 no 2183 0.357794338658666 3248 9102229
SGTC_651 3253-0966 34.4 µM -0.365486508784933 0.356653000218211 no 2184 0.357374137871857 3059 781462
SGTC_2224 6650123 117.647 µM -0.366339820419924 0.356336343014327 no 2185 0.357055759654362 3072 2908370
SGTC_3234 9132280 49.47 µM -0.367623765811607 0.355860067686799 no 2186 0.356576895697283 3115 17612295
SGTC_2143 5623677 140.463 µM -0.36803439604601 0.355707793175934 no 2187 0.35642379352658 3118 5375313
SGTC_626 0214-0009 33 µM -0.368268439209376 0.355621012963043 no 2188 0.356336541630812 3189 3437874
SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM -0.368582884444219 0.355504432471206 no 2189 0.356219327474672 3074 115019
SGTC_2960 9079389 5.97 µM -0.368976183897452 0.355358635825824 no 2190 0.356072738353661 3202 16457355
SGTC_2520 obtusaquinone 4.71 µM -0.369450761293866 0.355182737516769 no 2191 0.355895883938522 3215 5967872
SGTC_2218 6965428 192.983 µM -0.369502369868982 0.355163611071307 no 2192 0.355876653529228 3134 675684
SGTC_2773 thioridazine 9.09 µM -0.369744547623184 0.355073863426936 no 2193 0.355786418049748 3095 5452 An antipsychotic.
SGTC_2851 9015922 71.43 µM -0.370545876173759 0.354776959756016 no 2194 0.355487900494328 3222 2996893
SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM -0.371595065491367 0.354388353473774 no 2195 0.355097181801036 3189 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_2546 rhodinyl acetate 100 µM -0.371646839359617 0.354369181016703 no 2196 0.355077905123476 3197 6708682
SGTC_2961 9083290 32.55 µM -0.371812550908847 0.354307818611088 no 2197 0.355016209153994 3135 17741490
SGTC_502 l-744,832 89.3 µM -0.372002363660618 0.35423753626202 no 2198 0.354945544750721 3162 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.
SGTC_547 1120-0019 610 nM -0.373471968336329 0.353693550963739 no 2199 0.35439860228939 3042 3676939
SGTC_668 1682-0499 62.6 µM -0.373861795274179 0.353549303637094 no 2200 0.354253570800499 3112 682214
SGTC_1993 st073995 70.8 µM -0.374293137118831 0.3533897190928 no 2201 0.354093118708861 3066 3098394
SGTC_3184 9108758 49.47 µM -0.37429809098313 0.353387886449756 no 2202 0.354091276102994 3012 902885
SGTC_459 nigericin 15.3 µM -0.37600890045123 0.352755189529831 no 2203 0.35345513957944 3207 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification.
SGTC_2571 chrysanthemic acid 100 µM -0.377094357522453 0.352353973320956 no 2204 0.353051742130709 3095 2743 An insecticide.
SGTC_1859 st055998 20 µM -0.37783247296221 0.352081238374142 no 2205 0.352777524416795 3264 676301
SGTC_1413 3910-0535 34.4 µM -0.378087536723317 0.351987009546631 no 2206 0.352682783294895 3190 2876951
SGTC_782 0083-0095 30.5 µM -0.378145956913043 0.351965428512483 no 2207 0.352661084930718 3028 3591729 An indicator and reagent.
SGTC_810 3825-7150 143 µM -0.378973664292198 0.351659715947359 no 2208 0.35235371028057 3233 22330411 YGL099W LSG1
SGTC_1130 3454-2858 15.9 µM -0.379220385606973 0.351568608319477 no 2209 0.352262107318622 3113 715628 YIL048W NEO1
SGTC_1849 st056239 19.2 µM -0.379616983821003 0.351422173003029 no 2210 0.352114875858826 3050 5393181
SGTC_931 2812-0076 566 µM -0.380789967171367 0.350989203378146 no 2211 0.351679552229101 3035 3450959
SGTC_1625 st003711 30.1 µM -0.380865558554043 0.350961307842365 no 2212 0.351651505027424 3276 24207034 YER133W GLC7
SGTC_2036 5160441 105 µM -0.381280409171535 0.350808229560464 no 2213 0.351497594468308 3110 134534 YIL048W NEO1
SGTC_2951 9072950 58.06 µM -0.382285868780722 0.350437319341786 no 2214 0.351124667618709 3123 16488155
SGTC_2134 5324836 1.464 µM -0.382336424081645 0.350418673445445 no 2215 0.351105920344519 3059 699272
SGTC_2025 5147754 141 µM -0.382733602359591 0.350272197986826 no 2216 0.350958648496416 3127 315777 YLR208W SEC13
SGTC_918 glabranin 770.725 nM -0.383138469616038 0.350122909826282 no 2217 0.350808548651016 3113 124049 Also referred to as licorice root.
SGTC_311 1315-0136 58 µM -0.383669537907301 0.349927122218544 no 2218 0.350611696535638 3251 6759207
SGTC_2225 6654152 15.4 µM -0.384279229586081 0.349702397916021 no 2219 0.350385750390581 3137 97582 YGR029W | YLR033W ERV1 | RSC58
SGTC_2044 5102272 200 µM -0.386169842464513 0.349005878046813 no 2220 0.349685443469122 3183 592666
SGTC_3304 9125678 46.087 µM -0.38794455833347 0.348352518273962 no 2221 0.349028531295074 3081 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2
SGTC_166 k072-0058 166.424 µM -0.389121547264295 0.347919458936353 no 2222 0.34859311735984 3225 5846229
SGTC_2002 4023503 131 µM -0.389530961467216 0.347768866216545 no 2223 0.348441705850223 3263 4736863 YCR052W RSC6
SGTC_378 3970-0959 8.33 µM -0.390321833741072 0.347478031752462 no 2224 0.348149290089581 3198 6615653
SGTC_604 1000-0114 314 µM -0.390365877516478 0.347461837782068 no 2225 0.34813300807109 3224 1572745
SGTC_2846 9008642 19.48 µM -0.392349285430943 0.346732869346484 no 2226 0.347400076192278 3196 2992898
SGTC_2095 5432005 200 µM -0.392761508587925 0.346581434699936 no 2227 0.34724781819434 3086 783734
SGTC_1403 3909-7815 62.9 µM -0.393164214846174 0.346433519859811 no 2228 0.347099099143054 3059 6615483
SGTC_1426 4048-4480 71.7 µM -0.395456228236373 0.345592105072222 no 2229 0.346253109661399 3211 14224343
SGTC_1550 gossypolone 36.6 µM -0.395787528571833 0.345470545267776 no 2230 0.346130888958632 3094 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_669 0108-0021 26.2 µM -0.396575768167534 0.345181390651565 no 2231 0.345840162274853 3417 17201
SGTC_3125 9127534 49.47 µM -0.396765419759382 0.345111833110257 no 2232 0.34577022656795 3164 1639235
SGTC_2623 humulene 100 µM -0.397443985094575 0.344863002053216 no 2233 0.345520042693202 3171 6187145 An anti-inflammatory.
SGTC_2302 7771753 200 µM -0.3977193268688 0.344762052885834 no 2234 0.345418544700807 3163 2203047
SGTC_2645 abamectin 100 µM -0.398228108327553 0.344575546290159 no 2235 0.345231024141695 3197 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels.
SGTC_488 nitrendipine 139 µM -0.398724170214074 0.344393738742294 no 2236 0.345048228186553 3139 4507 Dihydropyridine L-type calcium channel blocker.
SGTC_2479 5617353 43.85 µM -0.398824513280544 0.344356967203048 no 2237 0.345011256737853 3267 2731746
SGTC_104 0074-0074 590.992 µM -0.399313889247524 0.34417765245744 no 2238 0.344830967148581 3081 3943124
SGTC_662 k832-1615 104 µM -0.399343363791992 0.344166853657185 no 2239 0.344820109641016 3187 5878478
SGTC_2925 9010536 32.5 µM -0.400194558464836 0.343855050214199 no 2240 0.344506611104939 3137 2994177
SGTC_2529 gangaleoidin 93.61 µM -0.400256998167562 0.343832181933539 no 2241 0.344483618504031 3070 4565183
SGTC_634 1611-4317 11.2 µM -0.400401479792113 0.343779268331971 no 2242 0.344430417245641 3235 2843522
SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM -0.400448475650587 0.343762057666942 no 2243 0.344413113017626 3077 442882
SGTC_2722 naftopidil 47.16 µM -0.40488095409229 0.342140270177789 no 2244 0.342782509439068 3224 4418 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_2459 5811157 9.22 µM -0.405402259547965 0.341949721665877 no 2245 0.342590925171034 3161 2870684 YBR192W RIM2
SGTC_2563 tomatine 8.54 µM -0.405893621644811 0.341770154951647 no 2246 0.342410382409332 3322 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties.
SGTC_873 0591-4978 488 µM -0.406392733815193 0.341587792643299 no 2247 0.342227028873569 3301 3305145
SGTC_2990 9074105 71.4286 µM -0.406407492309417 0.341582400844719 no 2248 0.3422216077682 3185 6502001
SGTC_2182 6325192 200 µM -0.406695374572487 0.341477233764586 no 2249 0.342115869061724 3223 736248
SGTC_1610 st001799 48.1 µM -0.408210711318783 0.340923864881452 no 2250 0.341559492483514 3057 621897
SGTC_1611 st001856 99.4 µM -0.408556963282469 0.340797468966439 no 2251 0.341432409598419 3150 647478
SGTC_1394 3474-0001 65.7 µM -0.408612360954655 0.340777248242444 no 2252 0.341412078974267 3157 5017666 YIL048W NEO1
SGTC_1244 0416-0015 52.5 µM -0.409019627431737 0.340628605809141 no 2253 0.341262628672408 3126 96201
SGTC_667 1498-1044 59 µM -0.410108099610613 0.34023146124435 no 2254 0.340863325696135 3152 6739982
SGTC_3191 9110352 49.47 µM -0.415557322504275 0.338245905880152 no 2255 0.33886698065961 3191 17122424
SGTC_1955 wogonin 32.4 µM -0.415679643059709 0.338201386770663 no 2256 0.338822219660392 3332 5281703 A flavanone.
SGTC_1453 4237-0541 195 µM -0.415767103028583 0.338169556713425 no 2257 0.338790216658895 3257 739892
SGTC_1607 st000305 50.6 µM -0.416900935148822 0.337757016225087 no 2258 0.338375434756372 3266 5457690
SGTC_1439 4092-1168 46 µM -0.417458241934848 0.33755431366908 no 2259 0.338171630924512 3202 2886240
SGTC_3171 9103192 49.47 µM -0.420783685843507 0.336345770827386 no 2260 0.33695652279619 3258 13018434
SGTC_2440 5628896 157.78 µM -0.421791866432648 0.335979707885674 no 2261 0.336588471498159 3126 5522048
SGTC_209 4077-0173 175.592 µM -0.421953287849417 0.33592111139416 no 2262 0.336529556737127 3214 15993494
SGTC_449 xestospongin c 11.1929 µM -0.422010216758419 0.335900446968942 no 2263 0.336508780072874 3234 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1
SGTC_1411 3909-8223 150 µM -0.423121260103779 0.335497252618447 no 2264 0.336103395845675 3243 X1411
SGTC_512 prima-1 270 µM -0.42345578745019 0.335375890702328 no 2265 0.335981374803694 3289 322968 A re-activator of the apoptotic function of mutant p53.
SGTC_950 1165-0508 94.1 µM -0.425189780279964 0.334747097490191 no 2266 0.335349166791083 3209 6148369
SGTC_2130 NSC 7 2.4545 µM -0.425808037775232 0.334523012319236 no 2267 0.335123864768959 3247 21448
SGTC_2275 7947463 200 µM -0.426177089747183 0.334389278865053 no 2268 0.33498940512495 3267 1225414
SGTC_3354 9151612 71.43 µM -0.427922663842511 0.333757019758122 no 2269 0.334353713016863 3270 27261949
SGTC_3143 9086658 49.47 µM -0.428037686049929 0.33371537446019 no 2270 0.33431184161047 3206 25236626
SGTC_28 pentachloropyridine N-oxide 1.606 µM -0.429141819520132 0.33331571274148 no 2271 0.333910010067408 3260 140250 A respiratory chain inhibitor.
SGTC_435 c-PAF 6.7 µM -0.429561886433486 0.333163711331224 no 2272 0.33375718346363 3257 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase
SGTC_2420 aureobasidin a 50 nM -0.431311498446463 0.332530908375773 no 2273 0.333120945388509 3376 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1
SGTC_487 nimodipine 119 µM -0.431387939367452 0.332503271941711 no 2274 0.333093158942604 3180 4497 L-type voltage-gated calcium channels inhibitor
SGTC_404 fumagillin 50 µM -0.433816723334203 0.331625644636443 no 2275 0.332210768299178 3237 12015870 A methionine aminopeptidase binder.
SGTC_706 4262-0057 46.9 µM -0.435436334148698 0.331040920331457 no 2276 0.331622870906866 3161 883298
SGTC_2833 9001315 45.46 µM -0.435721593890104 0.33093797629109 no 2277 0.33151936827038 3103 2989378
SGTC_1713 st033146 12.748 µM -0.436166802929585 0.330777335568519 no 2278 0.331357855904031 3312 674619
SGTC_2762 leflunomide 42.06 µM -0.437745986496816 0.330207784592411 no 2279 0.330785214785586 3185 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1
SGTC_1263 0774-1208 64.8 µM -0.437778504915559 0.330196060572753 no 2280 0.330773427160799 3345 906585
SGTC_2008 4012253 172 µM -0.437858252165117 0.330167309624632 no 2281 0.330744520233855 3142 603940
SGTC_1123 mangostin 811.285 nM -0.439366948950078 0.329623574483655 no 2282 0.330197835443679 3217 5281650 An antioxidant.
SGTC_761 k216-0224 480 µM -0.439609204330419 0.329536299022752 no 2283 0.330110086568792 3335 1340404
SGTC_2676 harmalol 100 µM -0.441226186908049 0.328953999276584 no 2284 0.32952462848461 3274 5459187 A monoamine oxidase inhibitor
SGTC_2726 cimetidine 79.27 µM -0.441786332529954 0.328752379091765 no 2285 0.329321914841798 3207 2756 A P450 inhibitor, histamine H2-receptor antagonist.
SGTC_2895 9054447 58.44 µM -0.443236768332515 0.328230537375359 no 2286 0.328797243262335 3191 2697450
SGTC_3310 9130229 44.1445 µM -0.443918696265606 0.32798530721509 no 2287 0.328550683395559 3292 7761258
SGTC_172 1112-0046 2.638 µM -0.443973827785001 0.32796548444107 no 2288 0.328530753140789 3162 2802135 YIL048W NEO1
SGTC_1905 st060207 84.5 µM -0.447735866677256 0.326613974574833 no 2289 0.327171916678774 3150 1948547
SGTC_2560 caryophyllene 100 µM -0.447929897331349 0.326544330671021 no 2290 0.32710189530901 3188 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor.
SGTC_1743 st037606 46.3785 µM -0.448216784596521 0.326441368590729 no 2291 0.326998375194291 3185 590142 YLR208W | YDL195W SEC13 | SEC31
SGTC_1644 st010134 20.9 µM -0.448644682335488 0.326287823285498 no 2292 0.32684399773487 3302 3818134
SGTC_2469 5655019 90.81 µM -0.449464772847265 0.325993627207699 no 2293 0.326548207338056 3314 2788239
SGTC_977 1348-1378 135 µM -0.450062462789089 0.325779282451283 no 2294 0.326332701084807 3160 X977
SGTC_877 0771-0151 33.1 µM -0.453216531966818 0.324649118897091 no 2295 0.325196414639951 3254 6166523
SGTC_1609 st001574 46.4 µM -0.454368373611756 0.324236793336453 no 2296 0.324781855766808 3191 3960012
SGTC_2733 amorolfine 100 µM -0.454715878450479 0.324112439069593 no 2297 0.324656828008398 3256 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_1612 st002233 45.4 µM -0.455017037965959 0.324004685301385 no 2298 0.324548490677614 3293 1035021
SGTC_2487 5918373 44.05 µM -0.457940034472299 0.322959615069192 no 2299 0.32349776174078 3380 2876279
SGTC_574 1315-0397 40 µM -0.459562596042074 0.322380096430055 no 2300 0.322915106072808 3238 6794277
SGTC_863 0466-0191 129 µM -0.459882898867288 0.322265747115419 no 2301 0.322800137841781 3311 765160 YPR165W RHO1
SGTC_3080 9117754 49.47 µM -0.460162576802027 0.32216591479278 no 2302 0.322699765196514 3393 9550191
SGTC_2297 7971671 152.32 µM -0.460226351041673 0.322143152081084 no 2303 0.322676879288837 3357 909016
SGTC_1008 4106-0037 6 µM -0.461223742793286 0.321787243449186 no 2304 0.322319044544115 3146 2905394
SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM -0.461641271821857 0.321638301174254 no 2305 0.322169296293774 3329 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_2864 9034755 47.6 µM -0.464255757668918 0.320706305991403 no 2306 0.321232258777888 3321 4930451
SGTC_2985 9022375 71.43 µM -0.464811271280918 0.320508425289293 no 2307 0.321033307715565 3377 4939335
SGTC_1838 st055369 84.5 µM -0.468316065352517 0.319261153056033 no 2308 0.319779290708837 3272 676036
SGTC_819 1013-0258 27.7 µM -0.4686903704668 0.319128067325677 no 2309 0.31964548549584 3238 5753198
SGTC_1903 st060211 78.3 µM -0.470059670656631 0.318641405685566 no 2310 0.319156193211748 3355 688960
SGTC_726 3448-4391 34.2 µM -0.471509323797958 0.318126526577212 no 2311 0.318638531495677 3432 1356692
SGTC_1626 st003712 1.76 µM -0.471611968882748 0.318090083016808 no 2312 0.318601891002346 3342 24207035
SGTC_2490 carminic acid 95.39 µM -0.471688550644058 0.318062894240062 no 2313 0.318574555305408 3324 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_1810 st050138 53 µM -0.472847849670077 0.317651428837195 no 2314 0.318160866666732 3323 3444541
SGTC_1035 k081-0041 55.2 µM -0.473367145233687 0.317467190300168 no 2315 0.31797563277359 3369 731709
SGTC_1675 st018485 24.5 µM -0.473371804738465 0.317465537380004 no 2316 0.317973970923808 3239 3323024
SGTC_1105 epirubicin 18.1 µM -0.473460629761139 0.317434028145687 no 2317 0.317942291467451 3211 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_1522 st012842 45.6 µM -0.473794892917945 0.31731546557633 no 2318 0.317823088409005 3188 3491067 YOR116C RPO31
SGTC_1299 1079-1439 3.74 µM -0.475076388031934 0.316861095216885 no 2319 0.317366263786811 3245 323161
SGTC_1518 st038567 90.8 µM -0.476106610837851 0.316496016791164 no 2320 0.316999213753371 3317 77966
SGTC_1487 3970-0795 2.82 µM -0.47764763873386 0.315950258859537 no 2321 0.316450509041168 3329 3765103
SGTC_1547 harmine 94.2 µM -0.47831720084241 0.315713257041106 no 2322 0.316212227770608 3292 5280953 A monoamine oxidase inhibitor YHR072W ERG7
SGTC_1868 st057644 42.7 µM -0.478972123125585 0.315481510502848 no 2323 0.315979230282292 3218 688665
SGTC_1207 2099-0101 141 µM -0.479213871835849 0.315395985206871 no 2324 0.315893243360361 3338 5837381
SGTC_636 0kpi-0074 126 µM -0.479565685415499 0.315271539087274 no 2325 0.315768125570193 3283 616434
SGTC_1755 st041960 45.185 µM -0.48045054976283 0.314958630946727 no 2326 0.315453528745122 3353 2257073
SGTC_3053 9095903 49.47 µM -0.482932675761703 0.314081603893786 no 2327 0.314571769905387 3353 17174018
SGTC_2257 7960413 200 µM -0.483041056228018 0.314043332926362 no 2328 0.314533292500506 3233 2974689 YIL048W NEO1
SGTC_3229 9132204 49.47 µM -0.48330872200783 0.313948824201798 no 2329 0.31443827400238 3237 17682924
SGTC_3348 9149464 3.537 µM -0.483791092018381 0.313778537485869 no 2330 0.314267068829379 3309 1951442
SGTC_2051 5263410 176 µM -0.484666990172347 0.313469428506879 no 2331 0.313956292833621 3387 227584
SGTC_742 0kpi-0133 140 µM -0.485532105986518 0.313164253210487 no 2332 0.313649471978223 3371 2728852
SGTC_1202 1988-0068 29.6 µM -0.485918614384643 0.313027951160357 no 2333 0.313512435042169 3250 2850480
SGTC_1281 0884-0031 11.8 µM -0.486411393349811 0.312854209884742 no 2334 0.313337757094307 3280 1548255
SGTC_2258 7960471 200 µM -0.486441160644325 0.31284371602784 no 2335 0.313327206665581 3282 2974708
SGTC_675 1309-0189 238 µM -0.487551536762783 0.312452383813712 no 2336 0.31293376500932 3287 4246530
SGTC_397 arbidol 50 µM -0.488163742322137 0.312236713288924 no 2337 0.312716932106445 3377 131410 A RNA synthesis inhibitor.
SGTC_3019 9081971 49.47 µM -0.489643981563364 0.311715513849739 no 2338 0.312192924129501 3423 16451803
SGTC_3010 9080089 71.4286 µM -0.489819646913286 0.3116536862256 no 2339 0.312130763389856 3330 17027233
SGTC_2398 5228213 48.84 µM -0.490396467254752 0.311450704415894 no 2340 0.311926688026495 3421 80771 YMR134W ERG29
SGTC_2023 5144124 124 µM -0.493106788854205 0.310497716148396 no 2341 0.310968567116263 3233 2830192
SGTC_802 4112-3352 742 µM -0.493490279434141 0.310362977774013 no 2342 0.310833103268659 3385 704594
SGTC_37 0566-0070 1.56 µM -0.494056376506992 0.310164127612678 no 2343 0.3106331825308 3309 1626686
SGTC_2394 5221648 200 µM -0.494408030133064 0.310040631896828 no 2344 0.310509021991279 3364 788586
SGTC_2411 st077133 39.94 µM -0.497675555043647 0.308894149938231 no 2345 0.309356370201945 3494 1403142 YNL221C POP1
SGTC_2868 9035608 32.47 µM -0.498713401147127 0.308530387700735 no 2346 0.308990651174412 3309 6462614
SGTC_1703 st026983 48.3 µM -0.499206021670322 0.308357791267459 no 2347 0.308817126429669 3392 1104023
SGTC_2552 juarezic acid 87.02 µM -0.500009861355942 0.308076245832993 no 2348 0.308534066893044 3327 1549512
SGTC_227 fluconazole 33.516 µM -0.500456618463225 0.307919817632927 no 2349 0.308376797553156 3316 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C
SGTC_864 0469-0573 172 µM -0.500819253478198 0.307792869725688 no 2350 0.308249167081144 3293 689425
SGTC_348 k064-0012 10.7 µM -0.50123206261891 0.307648385325043 no 2351 0.308103905886607 3287 5066323
SGTC_2145 5634607 200 µM -0.501247876718659 0.307642850937231 no 2352 0.308098341745445 3255 308662
SGTC_15 0266-0086 27.098 µM -0.501850383859762 0.307432026897369 no 2353 0.307886384367257 3409 1712902 YIL048W NEO1
SGTC_638 3970-0837 4.09 µM -0.502165243052796 0.307321879415861 no 2354 0.307775644814361 3299 4118451 YLR208W SEC13
SGTC_1404 3909-7820 48.3 µM -0.504257003358639 0.306590558559547 no 2355 0.307040393874696 3384 23741373
SGTC_1185 1319-0113 81.3 µM -0.50455204878148 0.306487466686897 no 2356 0.306936748126076 3373 4672763
SGTC_3164 9100705 49.47 µM -0.506729860921322 0.305726991046518 no 2357 0.306172187764141 3423 17174235
SGTC_933 2914-0560 114 µM -0.507122777348438 0.305589876623211 no 2358 0.306034337059225 3417 463887
SGTC_687 k029-0044 34.9 µM -0.508562753311741 0.305087607272967 no 2359 0.305529371127125 3390 5829338
SGTC_572 0960-0087 17.7 µM -0.510209772348631 0.304513570299579 no 2360 0.304952253278511 3319 6796365
SGTC_1553 gossypol 38.6 µM -0.510225816497284 0.304507980782726 no 2361 0.304946633767895 3329 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_1724 st037281 8.293 µM -0.511471613330141 0.304074105187803 no 2362 0.304510430282193 3300 574124 YDL195W SEC31
SGTC_296 1222-0039 74.9 µM -0.513204873798047 0.303470918679739 no 2363 0.303904008524467 3326 5984176
SGTC_1606 st000094 49.2 µM -0.514275766001785 0.303098508204158 no 2364 0.303529601207065 3430 1242210
SGTC_818 4072-2707 53.5 µM -0.514615940166822 0.302980252985862 no 2365 0.303410712011226 3288 882871
SGTC_860 0443-0016 25.1 µM -0.515725620565253 0.30259463686224 no 2366 0.303023028898504 3372 5337942
SGTC_2887 9044784 58.44 µM -0.516003133265272 0.302498235044514 no 2367 0.302926110426069 3351 6465546
SGTC_1310 1188-0297 994 nM -0.516162251564041 0.302442967053188 no 2368 0.302870546246776 3314 1588352
SGTC_1946 st076057 65.1 µM -0.517133666295745 0.302105655077445 no 2369 0.302531426806519 3316 953009
SGTC_2818 7996756 12.99 µM -0.519780161863552 0.301187549710251 no 2370 0.301608403870066 3291 2241621
SGTC_1497 4476-2978 41.3 µM -0.520107738454954 0.301073996400436 no 2371 0.301494242553871 3388 1528379
SGTC_101 0490-5701 117.494 µM -0.520234280144926 0.30103013632152 no 2372 0.301450147644337 3367 4661669
SGTC_1256 0570-0116 285 µM -0.521751038276131 0.300504643530211 no 2373 0.300921841862031 3330 410638
SGTC_1215 3852-0577 11.2 µM -0.523166663050182 0.300014563306587 no 2374 0.300429139122473 3445 2884876
SGTC_2595 hexamethylquercetagetin 100 µM -0.524479497410072 0.29956039192331 no 2375 0.299972538171231 3314 386331
SGTC_2634 4'-methoxyflavone 100 µM -0.524828062600139 0.299439859135829 no 2376 0.299851360728478 3343 77793 From seeds of Psoralea corylifolia (Fabaceae)
SGTC_1222 0366-0074 1.18 µM -0.525639035613305 0.29915951225331 no 2377 0.29956951465478 3431 286520
SGTC_525 k781-2675 26.7 µM -0.528200415584302 0.298274847001453 no 2378 0.298680120492738 3432 3651118 YDL195W SEC31
SGTC_2485 5633444 17.78 µM -0.528820368183877 0.298060903115763 no 2379 0.29846503343607 3374 5724239
SGTC_1789 tunicamycin 25 nM -0.529070730854685 0.297974523493252 no 2380 0.298378192309522 3424 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_2011 4012611 177 µM -0.530248149662436 0.297568445937912 no 2381 0.29796994557449 3320 2049887
SGTC_16 erodoxin 22.806 µM -0.530703808270348 0.297411362602625 no 2382 0.297812023305949 3446 3967339 Erodoxin inhibits Ero1. YML130C ERO1
SGTC_1033 k072-0102 21.3 µM -0.531706275843001 0.297065906233099 no 2383 0.297464722301969 3428 5965931
SGTC_3258 9138477 49.47 µM -0.533182102720298 0.296557661605674 no 2384 0.296953764656649 3414 4970355
SGTC_394 menadione 8.33 µM -0.533455502530449 0.296463552049492 no 2385 0.296859152854962 3413 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_1997 st073024 93.8 µM -0.53367387959743 0.29638839223029 no 2386 0.296783591946978 3425 686268
SGTC_1752 st044819 83.042 µM -0.533821979011997 0.296337425158683 no 2387 0.296732352903547 3314 441209 YML126C ERG13
SGTC_741 4582-0002 126 µM -0.533897460561844 0.296311450413305 no 2388 0.296706239555059 3333 2912688
SGTC_2889 9059656 51.95 µM -0.534174904303317 0.296215985318757 no 2389 0.296610265075171 3404 3949838
SGTC_1512 0259-0544 12.2 µM -0.534265908073432 0.296184675075921 no 2390 0.296578787774236 3400 18476
SGTC_1804 st050076 49.1 µM -0.534659267089113 0.29604935566398 no 2391 0.296442746401033 3422 3895976
SGTC_709 3807-1509 243 µM -0.535769537651931 0.295667564716684 no 2392 0.296058918907223 3427 1886677 YPL242C IQG1
SGTC_3294 9122953 26.2835 µM -0.536118365253943 0.295547659409609 no 2393 0.295938374124258 3407 16459826
SGTC_1468 k284-1086 134 µM -0.537353912525102 0.29512313480347 no 2394 0.295511585926763 3403 15996457
SGTC_2327 6189656 200 µM -0.53746042561576 0.29508655086981 no 2395 0.295474806959929 3411 5349088
SGTC_2754 granisetron 64.02 µM -0.537651786625907 0.29502082956245 no 2396 0.29540873529854 3458 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients.
SGTC_2007 4011539 71.82 µM -0.53804493369576 0.294885827714824 no 2397 0.295273013824823 3394 45595301
SGTC_43 0570-0105 72.5 µM -0.538130421138952 0.294856476151842 no 2398 0.295243505813576 3416 1114046 YDL195W SEC31
SGTC_884 0851-0618 334 µM -0.538228944306625 0.294822650527215 no 2399 0.295209499897681 3432 9642473
SGTC_2883 9059145 45.46 µM -0.538544397637205 0.29471435904123 no 2400 0.295100631247752 3321 16476510
SGTC_1338 1486-1223 76 µM -0.539392750146408 0.294423220459343 no 2401 0.294807941218633 3395 3444526
SGTC_1474 0330-0125 5.35 µM -0.539496282954939 0.294387699044279 no 2402 0.294772230537824 3438 X1474
SGTC_1650 st011916 45.8 µM -0.539658585893298 0.294332017972762 no 2403 0.294716252796185 3450 242528
SGTC_771 0250-0039 27.3 µM -0.541143000943354 0.293822987308601 no 2404 0.294204510607252 3329 3005115
SGTC_2228 7354201 200 µM -0.541417868203964 0.293728775449632 no 2405 0.2941097970166 3404 753451
SGTC_2618 avocadyne 43.43 µM -0.542507636040505 0.293355390797417 no 2406 0.293734424249422 3376 3015189
SGTC_637 1181-0519 7.26 µM -0.542671405801714 0.293299297755354 no 2407 0.293678032586995 3432 6252091 YGR060W ERG25
SGTC_183 3914-0051 30.55 µM -0.542813753584956 0.293250546027728 no 2408 0.293629021332598 3427 1596232
SGTC_67 0335-0847 266 µM -0.544063247687174 0.292822776549823 no 2409 0.293198975087726 3540 4552207 YOR254C SEC63
SGTC_455 paf C-16 10 µM -0.544293139684257 0.292744103636857 no 2410 0.293119883530571 3397 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis.
SGTC_983 1491-0821 12.2 µM -0.546039261694409 0.292146871940904 no 2411 0.292519474645583 3437 46495113
SGTC_1177 0983-0204 23.6 µM -0.546196324268642 0.292093179131825 no 2412 0.292465496274431 3472 766818
SGTC_426 0988-0037 14.6 µM -0.547604512287838 0.291611986698817 no 2413 0.291981745212625 3490 5383008
SGTC_1623 st003709 20.3 µM -0.547621926537193 0.29160603838353 no 2414 0.29197576527494 3404 16192618
SGTC_917 harmaline 728.087 nM -0.547950294407542 0.291493885907887 no 2415 0.291863016604288 3384 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7
SGTC_999 SEC7.066 22.7 µM -0.549727208930986 0.290887338526052 no 2416 0.291253245826402 3398 740511 YDR170C SEC7
SGTC_1097 itavastatin 7.23 µM -0.549995831755978 0.290795695840265 no 2417 0.291161116263658 3440 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49
SGTC_835 0312-0010 67.2 µM -0.550084729816007 0.290765370575302 no 2418 0.291130629895696 3381 1626196
SGTC_1493 4348-0038 111 µM -0.550890435083701 0.290490592601017 no 2419 0.290854392351889 3462 800424
SGTC_2841 9004761 38.96 µM -0.551392227743176 0.290319522515959 no 2420 0.290682413746581 3344 2991039
SGTC_928 2764-0428 58.7 µM -0.552702238177938 0.289873139052823 no 2421 0.290233660252959 3446 662578
SGTC_2809 7964133 12.99 µM -0.552938115495398 0.289792798536491 no 2422 0.290152893272863 3377 1253665
SGTC_430 0958-0115 16.4 µM -0.554015753519402 0.289425884773604 no 2423 0.289784032233873 3342 6833180
SGTC_2081 5214970 32.255 µM -0.554359715609939 0.289308818659156 no 2424 0.289666344959389 3426 2063512
SGTC_2035 5154463 94.595 µM -0.555705091686392 0.288851139192646 no 2425 0.289206237626903 3473 2769623
SGTC_2043 5101342 149 µM -0.555711502581265 0.288848959105541 no 2426 0.289204045977356 3381 678451
SGTC_1525 8-methoxypsoralen 92.5 µM -0.555916038745425 0.288779408660693 no 2427 0.289134126672209 3520 4114 Related to psoralen; DNA damaging agent.
SGTC_1660 st012960 28.1 µM -0.55599179245145 0.288753651383453 no 2428 0.289108232797161 3412 24207266
SGTC_3014 9081533 49.47 µM -0.558144169835307 0.288022266566744 no 2429 0.288372970548839 3472 21367265
SGTC_1806 st050005 60.3 µM -0.558523669457609 0.287893402099365 no 2430 0.288243423169048 3386 5194765
SGTC_926 2268-1401 59.4 µM -0.559138333818925 0.287684741896597 no 2431 0.288033657346737 3461 2931578
SGTC_3283 9109332 35.8195 µM -0.561197652864164 0.286986185867792 no 2432 0.287331401422708 3353 17027281
SGTC_73 0327-0325 16.231 µM -0.561811679830046 0.286778053093154 no 2433 0.287122166729401 3467 53298
SGTC_1561 5-methoxyflavone 52.9 µM -0.562010847164807 0.286710557993005 no 2434 0.287054314334596 3435 94525
SGTC_538 2922-0838 53.3 µM -0.562329042776647 0.286602741460134 no 2435 0.286945927105898 3507 777039
SGTC_1203 3992-3522 103 µM -0.562577063093133 0.286518716271186 no 2436 0.286861457192982 3631 5322312
SGTC_1725 st036284 20.55 µM -0.565295940277741 0.285598372742556 no 2437 0.285936244784391 3514 707914
SGTC_3192 9110362 49.47 µM -0.565321979990051 0.285589565071408 no 2438 0.285927390538321 3525 16649480
SGTC_398 bronopol 33.3 µM -0.567228966664559 0.284944897635272 no 2439 0.285279315152379 3389 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them.
SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM -0.567580058997124 0.284826284620072 no 2440 0.285160075331415 3441 688788
SGTC_1587 estradiol valerate 56.1 µM -0.568887385268083 0.284384824887564 no 2441 0.284716283345241 3504 13791 A steroid.
SGTC_146 3448-8650 53.125 µM -0.571652603468083 0.283452140865218 no 2442 0.283778675164086 3441 2891488 YIL048W NEO1
SGTC_711 k292-0785 179 µM -0.572275703347375 0.283242177296771 no 2443 0.28356760369644 3487 4146315
SGTC_3077 9117319 49.47 µM -0.573015339553665 0.282993041806741 no 2444 0.283317153907507 3481 17154678
SGTC_555 4296-0685 37 µM -0.57721480593076 0.281580511673484 no 2445 0.281897178197662 3444 2908540 YHR072W ERG7
SGTC_2040 5100729 123 µM -0.577575497659367 0.281459348361405 no 2446 0.281775376713716 3427 11840 YJR013W | YDR381W GPI14 | YRA1
SGTC_204 PMA1.184 62.41 µM -0.577966279997261 0.281328105430462 no 2447 0.281643442609564 3467 2252213 YGL008C PMA1
SGTC_1959 st077091 55.8 µM -0.578303787961187 0.28121477829777 no 2448 0.281529518728919 3462 821356 YKL052C ASK1
SGTC_1686 st019653 115.5 µM -0.57843012048706 0.281172364516324 no 2449 0.281486881626443 3511 97252
SGTC_2653 dihydrofissinolide 100 µM -0.580345008172434 0.280529855407987 no 2450 0.280840990702972 3490 6857746
SGTC_1476 4112-3294 3.34 µM -0.582625381691825 0.279765641686599 no 2451 0.280072757497319 3516 704369
SGTC_1150 3909-7983 10.9 µM -0.583777560639668 0.279379900399533 no 2452 0.279684988568408 3413 23965914
SGTC_351 caspofungin 25 nM -0.584028037430004 0.279296076759869 no 2453 0.279600724420013 3490 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1
SGTC_2582 agaric acid 100 µM -0.585096755955441 0.278938560729755 no 2454 0.279241330014664 3480 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase.
SGTC_2124 5246320 200 µM -0.585352164072433 0.278853152593036 no 2455 0.27915547325217 3487 579342
SGTC_1210 3013-0140 750 nM -0.58607874084984 0.278610255894004 no 2456 0.278911300905353 3528 905973
SGTC_887 0885-0007 9.62 µM -0.587353518740063 0.278184343128662 no 2457 0.278483152125103 3516 5719458
SGTC_551 k048-0028 34.9 µM -0.590088424958575 0.277271663371089 no 2458 0.277565684313413 3526 6836383
SGTC_2217 6934799 96.0675 µM -0.59112073001263 0.276927548618047 no 2459 0.277219765518136 3481 675606
SGTC_317 4495-0002 170 µM -0.591205144141145 0.276899418758092 no 2460 0.277191488215819 3468 15991618
SGTC_2198 6589944 200 µM -0.591954019379353 0.276649927557661 no 2461 0.276940689509802 3469 5290268
SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM -0.592119929873505 0.276594668630749 no 2462 0.276885141036774 3407 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding.
SGTC_100 0086-0128 49.5915 µM -0.592473655172221 0.276476873291015 no 2463 0.27676672853126 3475 93297
SGTC_2399 5884133 200 µM -0.594686181195358 0.275740630635123 no 2464 0.276026630306362 3466 722445
SGTC_342 k048-0088 23.3 µM -0.594746202166165 0.275720671421859 no 2465 0.276006566614492 3454 6820570
SGTC_571 k831-0106 44.2 µM -0.595411659366582 0.275499429656342 no 2466 0.275784166892619 3504 4783639
SGTC_1910 st062352 60.4 µM -0.596070839459372 0.275280360938372 no 2467 0.275563951876274 3466 2245730
SGTC_3045 9092950 49.47 µM -0.597112361203925 0.274934401507119 no 2468 0.275216182757607 3560 44120432
SGTC_3065 9113888 49.47 µM -0.597357638289995 0.274852959666666 no 2469 0.27513431500455 3581 16648368
SGTC_3276 9139060 49.47 µM -0.598103132599328 0.274605498641494 no 2470 0.274885560086751 3547 4870619
SGTC_3286 9117135 37.221 µM -0.598248621338641 0.274557217608304 no 2471 0.274837026650535 3417 3438150
SGTC_3247 9135149 49.47 µM -0.599811733163551 0.274038756913403 no 2472 0.274315856434934 3495 8934436 YOR116C RPO31
SGTC_3169 9102970 49.47 µM -0.599849115205293 0.274026363777891 no 2473 0.27430339855163 3560 17027839
SGTC_2522 biochanin a 4.94 µM -0.602297458015362 0.273215277018656 no 2474 0.273488076304821 3516 5280373 A possible chelator.
SGTC_733 4069-0007 56.1 µM -0.603160692637585 0.272929588613182 no 2475 0.273200896993095 3552 5717425 YNL287W SEC21
SGTC_563 tetrahydrosecaminediol 614 µM -0.604396582268937 0.272520827670177 no 2476 0.272790003744969 3563 334274 A psychoactive constituent of the cannabis plant.
SGTC_2938 9059746 27.26 µM -0.604787825031422 0.272391490522495 no 2477 0.272659992123857 3498 6471769
SGTC_1865 st057639 52.2 µM -0.60540851014292 0.272186366828631 no 2478 0.272453798954051 3529 688818
SGTC_594 1487-1584 10.8 µM -0.605995837116253 0.271992338037698 no 2479 0.2722587587747 3448 5013332
SGTC_614 0462-0418 107 µM -0.606430140502995 0.271848906228931 no 2480 0.272114579468692 3425 5188303
SGTC_2029 5175081 200 µM -0.60711186720469 0.271623837022563 no 2481 0.271888337569813 3519 1380876
SGTC_642 0335-0876 158 µM -0.609231533748726 0.270924631264573 no 2482 0.271185490727593 3553 6812350
SGTC_2799 7812892 81.82 µM -0.611021801917369 0.270334783233579 no 2483 0.270592573498055 3548 20205235
SGTC_808 0711-0032 135 µM -0.611163719720788 0.270288052387318 no 2484 0.270545599588771 3519 4252555
SGTC_3238 9133470 49.47 µM -0.61424843764176 0.269273312200317 no 2485 0.269525584859919 3565 3534688
SGTC_371 0195-0006 7.36 µM -0.615166311100955 0.268971740383111 no 2486 0.269222446782123 3469 3928593
SGTC_2291 7917025 104.35 µM -0.615399102134608 0.268895282711775 no 2487 0.269145592110211 3496 2964612
SGTC_224 benfluorex 43.875 µM -0.615746181699056 0.268781308489547 no 2488 0.269031026156631 3543 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis.
SGTC_1417 3966-0327 90.4 µM -0.615987817487446 0.2687019742957 no 2489 0.26895128012578 3547 651118
SGTC_688 0527-0193 473 µM -0.616287711066309 0.268603529188213 no 2490 0.268852324030793 3508 4007154
SGTC_949 1165-0505 146 µM -0.616471816648496 0.268543102417558 no 2491 0.268791583641513 3524 6244267
SGTC_739 1486-1183 203 µM -0.617046651285924 0.268354475313685 no 2492 0.268601977706096 3548 4346692
SGTC_2822 7994718 71.43 µM -0.617237398992583 0.268291897802084 no 2493 0.268539075516515 3506 1018011
SGTC_2752 diclazuril 33.15 µM -0.617307752969258 0.26826881902762 no 2494 0.268515877006362 3559 456389 An antifungal agent for coccidioides. YHR062C RPP1
SGTC_1633 st005664 67.9 µM -0.617418474739234 0.268232500107752 no 2495 0.268479369666331 3524 2063822
SGTC_1363 1636-0063 10.4 µM -0.61807380747729 0.268017588736676 no 2496 0.268263343527821 3561 6072185
SGTC_1461 k072-0203 53.8 µM -0.618213053294141 0.26797193530325 no 2497 0.268217453324738 3491 5418714
SGTC_1273 0849-0096 14.1 µM -0.618595161564268 0.267846676582058 no 2498 0.268091545052831 3522 5286025
SGTC_2627 acetyl isogambogic acid 100 µM -0.61897496322091 0.267722203224286 no 2499 0.267966426320313 3506 6857789 A caspase activator and apoptosis inducer.
SGTC_3204 9114183 49.47 µM -0.619069097754079 0.267691356783891 no 2500 0.267935419961934 3550 17027248
SGTC_2715 st079500 56.4 µM -0.619242782305904 0.267634447725994 no 2501 0.267878215885606 3522 28246688
SGTC_829 1635-0120 117 µM -0.619849575898427 0.267435675094136 no 2502 0.267678412979479 3548 285054
SGTC_655 k060-0012 42 µM -0.620386311391593 0.267259914081504 no 2503 0.267501741186095 3482 5994525
SGTC_2971 9092186 9.93 µM -0.622091630317493 0.266701872323748 no 2504 0.266940809072552 3440 25236400
SGTC_3268 9137683 49.47 µM -0.622744126146068 0.266488508096771 no 2505 0.26672634028943 3556 1953228
SGTC_3333 9141820 12.094 µM -0.623362786602966 0.266286287707484 no 2506 0.266523073319146 3520 1939433
SGTC_1592 4',5'-dihydroxyflavone 8.85 µM -0.624190867770313 0.266015735965651 no 2507 0.266251121786382 3567 688669
SGTC_3154 9100113 49.47 µM -0.628608731481432 0.264574682779513 no 2508 0.264802621299802 3510 25237525
SGTC_2412 st077135 33.4 µM -0.628763542264482 0.264524257509025 no 2509 0.264751935694382 3641 13258915
SGTC_1357 1503-1303 39.5 µM -0.629777387168785 0.264194146886334 no 2510 0.264420121220153 3562 292895
SGTC_3356 9151811 4.48 µM -0.629802643646223 0.264185925988836 no 2511 0.264411857900597 3521 1859254 YPR165W RHO1
SGTC_2993 9054257 71.4286 µM -0.631455722002301 0.263648138100255 no 2512 0.263871295914089 3570 6470217 YGL055W OLE1
SGTC_109 0132-0036 33.701 µM -0.63306399079641 0.263125464396414 no 2513 0.263345928037044 3474 67274 A color developer.
SGTC_1347 1493-0251 600 nM -0.633691705587161 0.262921606160736 no 2514 0.263141019521043 3578 3986378
SGTC_1712 st032288 53.4 µM -0.635727321357392 0.262261070431831 no 2515 0.262477082748845 3588 2883011
SGTC_1237 0330-0133 46.1 µM -0.636309793600983 0.262072220908313 no 2516 0.262287261432483 3533 X1237 YHR072W ERG7
SGTC_948 3448-0295 75.3 µM -0.636897471647746 0.261881754217797 no 2517 0.262095814888851 3602 678569
SGTC_9 0092-0002 10.449 µM -0.637995289365176 0.261526141323697 no 2518 0.261738373254593 3562 759368
SGTC_349 k015-0014 24 µM -0.641183597050709 0.260494769398279 no 2519 0.260701702730505 3552 2196908
SGTC_121 0557-0495 61.343 µM -0.641398147885091 0.260425440561632 no 2520 0.260632018003115 3687 3104427
SGTC_2305 7443522 69.23 µM -0.641863361575298 0.260275146487997 no 2521 0.260480952536343 3548 5415886
SGTC_1241 0364-0022 50.8 µM -0.642113047035976 0.260194500389532 no 2522 0.260399892586174 3557 4563895
SGTC_1534 6-azauridine 81.6 µM -0.642464336244399 0.260081059028503 no 2523 0.260285869159788 3591 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1
SGTC_2350 9023895 38.85 µM -0.642582263316976 0.26004298271199 no 2524 0.260247597495924 3575 2997209
SGTC_384 k007-0144 5.16 µM -0.643545972165988 0.259731927964235 no 2525 0.259934947312877 3593 6824886
SGTC_2892 9047358 58.44 µM -0.644623205446873 0.259384458543813 no 2526 0.259585696538313 3559 6466771
SGTC_811 0416-0114 265 µM -0.645844648671382 0.258990763878078 no 2527 0.259189984634969 3592 6612453
SGTC_3201 9113999 49.47 µM -0.646247231089109 0.258861071566612 no 2528 0.259059628054123 3575 16649224
SGTC_1839 st053978 48 µM -0.646544121725686 0.258765449496025 no 2529 0.258963516299661 3630 3788398
SGTC_582 0987-0078 156 µM -0.647453962677895 0.258472523245088 no 2530 0.258669090395435 3646 1625765
SGTC_1133 3473-0247 50 µM -0.647592174577083 0.258428040507664 no 2531 0.258624379983086 3539 711311
SGTC_1280 0880-0253 10.1 µM -0.655529008894161 0.255880282988456 no 2532 0.256063607794601 3574 6836607
SGTC_1921 5740136 50 µM -0.656304032425378 0.25563220152221 no 2533 0.255814261766401 3611 1774243
SGTC_3189 9110682 49.47 µM -0.657189844598582 0.255348811027159 no 2534 0.255529427322871 3630 17122418
SGTC_208 k072-0098 12.366 µM -0.658350146167829 0.254977853994672 no 2535 0.255156581132869 3617 5948901
SGTC_381 3461-2219 42.7 µM -0.659256997253109 0.254688123397007 no 2536 0.2548653758007 3592 2883159
SGTC_1312 1218-2183 165 µM -0.661050243267858 0.25411570568066 no 2537 0.254290046448835 3625 6744073
SGTC_846 0335-0850 148 µM -0.661257612891292 0.254049555281364 no 2538 0.254223559742106 3594 6819598
SGTC_2678 equilin 100 µM -0.661571020455078 0.25394959618697 no 2539 0.254123092524674 3635 3247 Equilin is an estrone commonly used hormone replacement therapy
SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM -0.661665802294516 0.253919370264368 no 2540 0.254092712970282 3592 5355888
SGTC_992 3909-8734 162 µM -0.662769607373131 0.253567505967748 no 2541 0.253739060769676 3613 4288319
SGTC_600 1495-0418 41.6 µM -0.663235790370109 0.253418975948643 no 2542 0.253589776337534 3620 5377768
SGTC_357 1325-0123 420 µM -0.666312838593273 0.252439749320822 no 2543 0.25260558054898 3607 1098503
SGTC_1191 1487-1166 10.6 µM -0.666328403847548 0.252434800975175 no 2544 0.252600607112619 3670 3955771
SGTC_3108 9121785 49.47 µM -0.66641383257247 0.252407643263298 no 2545 0.252573311700477 3577 17140271
SGTC_2314 7727897 200 µM -0.666610216174594 0.252345218938874 no 2546 0.252510570883345 3608 900724
SGTC_428 3448-4153 16.5 µM -0.666984160742476 0.252226375935298 no 2547 0.252391125432305 3588 3834874
SGTC_623 k072-0108 16.9 µM -0.667122734674909 0.252182343368605 no 2548 0.252346869682297 3597 5382803
SGTC_2056 5235370 200 µM -0.668673662934099 0.251689804813696 no 2549 0.251851835746764 3608 5511916
SGTC_1317 1273-0028 910 nM -0.669263902440017 0.251502492100162 no 2550 0.251663574569511 3610 5917803 YLR359W | YHR072W ADE13 | ERG7
SGTC_1007 4101-0031 70 µM -0.670820414998341 0.251008885764694 no 2551 0.251167470252039 3602 1146276
SGTC_2684 capsaicin 100 µM -0.671645061021122 0.250747579215705 no 2552 0.250904842145498 3639 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_1327 1436-0082 2.18 µM -0.671966524626998 0.250645755701364 no 2553 0.250802503815091 3616 15992205
SGTC_3146 9095609 49.47 µM -0.672900051407733 0.250350185527348 no 2554 0.250505439746537 3648 17173999
SGTC_2874 9043904 71.43 µM -0.673437782067385 0.250180014923582 no 2555 0.25033440938952 3580 4463428
SGTC_1654 st012436 41.8 µM -0.673589783886766 0.25013192345026 no 2556 0.250286074988251 3603 4323132
SGTC_2660 2',4'-dihydroxychalcone 17.14 µM -0.673975138910218 0.250010023921206 no 2557 0.25016355978763 3637 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_1958 st076513 41.9 µM -0.674040552139617 0.249989334854738 no 2558 0.250142766240568 3594 732122 YGL099W LSG1
SGTC_748 act1.228 77.9 µM -0.674336066824038 0.249895880025449 no 2559 0.25004883950631 3599 4421505 YNR035C ARC35
SGTC_171 k064-0041 9.68 µM -0.674688490745786 0.249784452224336 no 2560 0.24993684914241 3596 53325
SGTC_888 0916-0002 6.97 µM -0.674956486139735 0.249699736314163 no 2561 0.249851705600263 3674 2802138 YIL048W NEO1
SGTC_1262 0737-0114 49.6 µM -0.675352037313113 0.249574726687266 no 2562 0.249726065057759 3664 765919
SGTC_193 1273-0060 1.558 µM -0.675863179428155 0.249413235062059 no 2563 0.249563758593338 3526 2847393 YHR072W ERG7
SGTC_1464 k208-0027 110 µM -0.676933430772716 0.249075276926007 no 2564 0.249224095946905 3659 X1464
SGTC_2821 7996764 71.43 µM -0.676948561957913 0.24907050062995 no 2565 0.249219295568403 3706 2987135
SGTC_2929 9013348 24.6 µM -0.67809721982984 0.248708058634081 no 2566 0.248855026688817 3644 2995952
SGTC_2945 9067681 61.76 µM -0.678575415240929 0.248557253993018 no 2567 0.248703462254953 3718 16456930
SGTC_2607 solasodine 47.35 µM -0.680071944823245 0.248085620460534 no 2568 0.248229453789954 3666 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity.
SGTC_1674 st016616 23.6 µM -0.681643717461749 0.247590788441538 no 2569 0.247732132115519 3636 625830
SGTC_2758 dehydroepiandrosterone 69.35 µM -0.685005227729244 0.246534275798788 no 2570 0.246670311065567 3669 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem]
SGTC_479 n-linoleoylglycine 10 µM -0.686552783061204 0.246048696937415 no 2571 0.246182295768678 3655 6433346 An anti-infammatory.
SGTC_3241 9133421 49.47 µM -0.687272699408448 0.245822982634434 no 2572 0.245955449644803 3667 17018221
SGTC_2912 7964298 10.93 µM -0.687571313984097 0.245729391073346 no 2573 0.245861388913213 3693 2975850
SGTC_2478 5763493 32.33 µM -0.687775521799356 0.245665399426813 no 2574 0.245797076524794 3618 1365576 YLR208W SEC13
SGTC_2286 7945697 125 µM -0.688182452874745 0.245537908031188 no 2575 0.245668946221216 3631 1245733
SGTC_347 4534-1311 26.2 µM -0.68850427772665 0.245437105568024 no 2576 0.245567638702617 3673 2862016
SGTC_1309 pyrazolanthrone 13.4 µM -0.688673527167016 0.245384101928143 no 2577 0.245514369532973 3671 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14
SGTC_2031 5180455 200 µM -0.68963100429877 0.245084365861535 no 2578 0.245213132372958 3645 29949
SGTC_1734 st037168 69.4 µM -0.68992048221587 0.244993784234044 no 2579 0.245122097268844 3666 708907
SGTC_1124 fisetin 1.16336 µM -0.690493007823601 0.244814686136783 no 2580 0.244942102777226 3661 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster.
SGTC_2324 6149169 200 µM -0.690756461006445 0.2447322961009 no 2581 0.2448593004737 3602 2888231
SGTC_2243 6634756 200 µM -0.691218856643695 0.244587726648834 no 2582 0.244714007767353 3702 885676
SGTC_1790 st045711 43.5 µM -0.691716085747419 0.244432317742767 no 2583 0.244557821592734 3683 585119
SGTC_1120 ficusin 1.78878 µM -0.691980057552541 0.24434983500792 no 2584 0.244474926415327 3714 6199 A DNA cross-linker.
SGTC_858 0438-0351 2.77 µM -0.692433528296935 0.244208174949628 no 2585 0.24433255815303 3676 2799119
SGTC_3337 9144342 33.5465 µM -0.693058811519181 0.244012914909176 no 2586 0.244136322247908 3674 17682949
SGTC_1383 3049-0032 20.7 µM -0.693083010516409 0.244005359871167 no 2587 0.244128729458625 3694 712864
SGTC_1708 st033234 31.827 µM -0.69315176402265 0.243983895399516 no 2588 0.244107157735434 3732 674664
SGTC_2160 5660466 132.927 µM -0.693279243591795 0.243944099665079 no 2589 0.244067163164876 3618 2859134
SGTC_1257 0669-0121 16 µM -0.694635876962228 0.243520811799915 no 2590 0.243641761283187 3691 4307855
SGTC_353 1988-1175 58.3 µM -0.694768136193483 0.243479566375087 no 2591 0.243600309956115 3542 2788357
SGTC_34 0469-0683 81.75 µM -0.695612087966024 0.243216466461173 no 2592 0.243335896987257 3658 3690923
SGTC_1067 clotrimazole 1.36 µM -0.695954496850905 0.243109765167824 no 2593 0.243228663362627 3696 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_793 0488-0545 106 µM -0.697337111473054 0.242679173044447 no 2594 0.242795924102135 3668 292548
SGTC_1817 st052116 64.4 µM -0.697658595305371 0.242579111496056 no 2595 0.242695363848051 3674 4361398
SGTC_1181 1222-0449 220 µM -0.698605978975886 0.242284369173064 no 2596 0.242399153079547 3710 658318
SGTC_1370 2001-0092 44.6 µM -0.69882933821008 0.242214907744265 no 2597 0.242329345703828 3742 790957
SGTC_1826 st055655 41.6 µM -0.700509134110989 0.24169286201354 no 2598 0.241804701427401 3711 676168
SGTC_2147 5545932 89.7195 µM -0.701415071269575 0.241411569253734 no 2599 0.241522009571234 3684 797404
SGTC_2401 5128683 200 µM -0.701760406955292 0.241304389636406 no 2600 0.241414297061333 3641 708373
SGTC_3023 9089636 49.47 µM -0.704218835392969 0.240542130771236 no 2601 0.240648251449085 3751 17249241
SGTC_2087 5276107 200 µM -0.704543062878635 0.240441698938418 no 2602 0.240547321107713 3658 144405
SGTC_1194 1488-0194 225 µM -0.705625447626958 0.240106587795919 no 2603 0.240210547295412 3649 1391452
SGTC_1128 3448-9350 235 µM -0.705631554105517 0.240104697925462 no 2604 0.240208648051354 3717 619386
SGTC_3275 9138069 49.47 µM -0.707021598175997 0.239674709637795 no 2605 0.239776527958913 3741 17617007
SGTC_1392 3455-1037 33.9 µM -0.710197899384207 0.238693750004944 no 2606 0.238790711661604 3695 981132
SGTC_1747 st037496 66.6 µM -0.710849657624539 0.23849273487104 no 2607 0.238588702483153 3719 723305
SGTC_862 0452-0056 10.2 µM -0.712221806345811 0.238069840169962 no 2608 0.238163717821112 3645 1575396 YLR359W | YHR072W ADE13 | ERG7
SGTC_1700 st030840 7.9285 µM -0.71517347731139 0.237161533035814 no 2609 0.237250927819734 3736 5499307
SGTC_358 0075-0058 9.45 µM -0.715466501568068 0.237071465731262 no 2610 0.237160416446465 3684 1069125
SGTC_1058 3448-5425 97.3 µM -0.71609495042045 0.236878361866804 no 2611 0.236966360775977 3623 7279705
SGTC_499 genistein 192 µM -0.717412717839679 0.236473731586949 no 2612 0.236559737299999 3705 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger.
SGTC_95 0471-0001 561.058 µM -0.717822354211337 0.236348027244386 no 2613 0.236433414079148 3640 4015405
SGTC_821 1114-0266 29.2 µM -0.717939882489167 0.236311968355842 no 2614 0.236397177692012 3721 3123235
SGTC_2356 9061756 188.97 µM -0.71805404327882 0.236276945547791 no 2615 0.236361982498075 3697 20104043
SGTC_2878 9043973 25.97 µM -0.719020053861275 0.235980702525601 no 2616 0.236064281836003 3764 6465167
SGTC_788 1182-0090 188 µM -0.720038263624915 0.235668673472254 no 2617 0.235750718436354 3817 5715185
SGTC_436 n,n-dimethylsphingosine 3.3 µM -0.72114170674345 0.235330781850575 no 2618 0.235411166417578 3791 5282309
SGTC_3322 9139058 2.11 µM -0.721193456023152 0.235314941975701 no 2619 0.235395248734416 3784 4908926 YPR165W RHO1
SGTC_1 0258-0098 57.368 µM -0.722447615825023 0.234931237741505 no 2620 0.235009660465574 3647 6790032 YDR047W HEM12
SGTC_1250 0485-0349 40.2 µM -0.72397066088394 0.234465734580594 no 2621 0.234541873668699 3724 6842794 YDL195W SEC31
SGTC_1597 7-benzyloxygramine 47.5 µM -0.724603411533953 0.234272490957869 no 2622 0.234347682703779 3692 260807
SGTC_1204 4049-0315 18.3 µM -0.724624366950294 0.234266092630154 no 2623 0.234341253016052 3790 588402
SGTC_980 1473-0395 201 µM -0.724759190299883 0.234224929262945 no 2624 0.23429988790574 3648 768876
SGTC_2462 5162487 171.77 µM -0.725914398312721 0.233872393035213 no 2625 0.233945624609169 3660 2259986
SGTC_2419 paclitaxel 166.5 µM -0.725974525822558 0.233854051903679 no 2626 0.233927193660271 3668 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_560 2332-1943 155 µM -0.726635461074845 0.233652494561356 no 2627 0.233724649514354 3702 21177716
SGTC_1857 st056007 79.3 µM -0.727124000247669 0.233503572673197 no 2628 0.233574998793838 3717 619834
SGTC_2344 7990960 76.95 µM -0.727680620809583 0.233333961646973 no 2629 0.233404557965189 3714 140813
SGTC_1943 st076331 65.2 µM -0.729349067331735 0.232825969587241 no 2630 0.232894082426757 3763 24208415
SGTC_1023 4482-3888 16 µM -0.730003801666944 0.232626790573632 no 2631 0.232693930408888 3713 3303168
SGTC_1100 amiodarone 5.07 µM -0.731816904443574 0.23207571491232 no 2632 0.232140164899576 3793 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death.
SGTC_2480 5767542 37.17 µM -0.732024602705341 0.232012633390982 no 2633 0.232076775678457 3722 2867358
SGTC_3062 9077494 49.47 µM -0.732528237157078 0.231859710625818 no 2634 0.231923107161522 3695 16459633
SGTC_1151 3909-8316 15.3 µM -0.73265761159327 0.231820436642554 no 2635 0.231883641692953 3759 800431
SGTC_1153 4055-0057 267 µM -0.733573605914445 0.231542475791204 no 2636 0.231604326081089 3745 882706
SGTC_214 4373-3496 70 µM -0.734157701805602 0.231365327430861 no 2637 0.231426314746129 3799 3779166
SGTC_892 0929-0076 29 µM -0.734458053522885 0.231274264264666 no 2638 0.231334808099138 3736 5751038
SGTC_719 2810-4230 27.3 µM -0.735398823658182 0.230989163070715 no 2639 0.231048319031353 3723 721079
SGTC_3161 9100388 49.47 µM -0.738493042385342 0.230052842643236 no 2640 0.230107446797824 3751 25236368
SGTC_328 k915-0120 63.5 µM -0.739240639115006 0.229826936466186 no 2641 0.229880443838704 3739 6624543
SGTC_210 3551-0445 56.827 µM -0.740623766651228 0.229409315444805 no 2642 0.229460796729135 3755 2865180 YOR207C RET1
SGTC_1720 st037298 9.481 µM -0.740630989449838 0.229407135712576 no 2643 0.229458606426974 3760 597396
SGTC_606 k015-0008 38.6 µM -0.743106743013016 0.228660674695122 no 2644 0.228708528770411 3773 1970475
SGTC_1870 st057514 26.5 µM -0.743885171393757 0.228426253987047 no 2645 0.228472973559579 3747 5393161
SGTC_2909 7941780 10.49 µM -0.744260664866976 0.228313223870647 no 2646 0.228359396641479 3724 1243215
SGTC_300 r073-0011 5.04 µM -0.746836632378714 0.227538660581225 no 2647 0.227581090125884 3765 2735780
SGTC_1410 3909-8106 77.9 µM -0.748849725486623 0.226934378543822 no 2648 0.226973892473294 3762 1039210
SGTC_615 k087-0205 167 µM -0.749951986324854 0.226603890251538 no 2649 0.226641811352039 3758 9642773
SGTC_3092 9117248 49.47 µM -0.750039512085862 0.226577659254842 no 2650 0.226615453985096 3821 17141857
SGTC_1945 st075991 56.6 µM -0.753061388041183 0.225673071218936 no 2651 0.225706512829741 3730 1084980
SGTC_2857 9024691 58.44 µM -0.753685318011256 0.225486554775531 no 2652 0.225519099988639 3834 16478292
SGTC_2856 9022925 19.48 µM -0.753918033376967 0.225417009633482 no 2653 0.225449220715539 3771 4944862
SGTC_1331 1472-0049 76.2 µM -0.753996508186184 0.225393560797052 no 2654 0.225425659231297 3716 24051409
SGTC_1624 st003710 6.25 µM -0.754335872144322 0.225292172310947 no 2655 0.225323783749808 3756 24207033
SGTC_1139 k015-0024 46.9 µM -0.755999311757216 0.224795576294239 no 2656 0.224824804173911 3740 2766652
SGTC_3212 9128307 49.47 µM -0.756268885663468 0.224715157356728 no 2657 0.224743999511632 3749 27243542
SGTC_1962 st076595 64.5 µM -0.756673811608229 0.224594391041134 no 2658 0.22462265408899 3782 279619
SGTC_1832 st054113 55 µM -0.757349150347976 0.224393057945014 no 2659 0.224420355924854 3719 1251267
SGTC_2100 5377183 190 µM -0.757390928890389 0.224380606222699 no 2660 0.224407844532136 3797 2844202
SGTC_1449 4112-4002 201 µM -0.757495156189495 0.224349543914587 no 2661 0.224376633376984 3778 2059539
SGTC_46 0329-0187a 2.197 µM -0.758382927273525 0.224085065177268 no 2662 0.224110887745449 3823 46494817
SGTC_231 b-estradiol 524 µM -0.759067216174086 0.223881327391298 no 2663 0.223906174583572 3709 450 A steroid.
SGTC_3018 9082602 49.47 µM -0.760339964079023 0.223502664007966 no 2664 0.223525699682344 3756 17332089
SGTC_2018 5133068 143 µM -0.760701356248291 0.22339521035491 no 2665 0.223417732281515 3766 785362
SGTC_3174 9107204 49.47 µM -0.761835417440398 0.223058207968389 no 2666 0.223079119536274 3778 3938802
SGTC_1428 4049-0204 61.7 µM -0.762086469959332 0.222983643304987 no 2667 0.223004198749289 3813 X1428
SGTC_2042 p-Dimethylaminoacetophenone 200 µM -0.762994440643258 0.222714087094846 no 2668 0.222733355680527 3783 75037 A free radical scavenger.
SGTC_2165 5727197 32.143 µM -0.763767362901 0.222484770156571 no 2669 0.222502944667515 3862 1361712
SGTC_2 0422-0095 29 µM -0.764076054083099 0.222393222755669 no 2670 0.222410960668032 3646 6790840
SGTC_552 k242-0005 476 µM -0.765458454473857 0.221983513053838 no 2671 0.221999298250791 3824 4088318
SGTC_1102 cgs 12066b 26.1 µM -0.765470313959018 0.221980000057666 no 2672 0.22199576852006 3784 6438352 A 5-HT1B full agonist.
SGTC_265 mycophenolic acid 32.932 µM -0.765780336503621 0.221888176977707 no 2673 0.221903508083019 3849 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1
SGTC_3224 9130643 49.47 µM -0.766698103476454 0.221616478165915 no 2674 0.221630515753621 3797 17644395
SGTC_1981 st071826 47 µM -0.766760293421144 0.221598074126975 no 2675 0.221612024127997 3793 11838600
SGTC_1723 st034307 2.5525 µM -0.767312692522238 0.22143463950476 no 2676 0.221447811883471 3837 867466
SGTC_2666 tannic acid 100 µM -0.767609319969883 0.221346906775367 no 2677 0.221359661854843 3784 16134267 A thiamine antagonist.
SGTC_1931 st074438 57.1 µM -0.768050402715642 0.221216485640433 no 2678 0.221228620546359 3749 2787313
SGTC_3219 9131112 49.47 µM -0.769191499873138 0.220879285449393 no 2679 0.220889817871235 3753 17612988 YMR079W SEC14
SGTC_1991 st073000 8.92 µM -0.769852114695874 0.220684204877439 no 2680 0.220693810845449 3833 4301969 YIL048W NEO1
SGTC_2586 curcumin 80 µM -0.770846800710323 0.220390658818181 no 2681 0.220398871587308 3803 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40
SGTC_2917 7979103 53.79 µM -0.771207432570715 0.22028428651005 no 2682 0.220291994685905 3835 2980565
SGTC_844 0330-0132 15.3 µM -0.77203215436599 0.220041136467668 no 2683 0.220047691745531 3813 2828079
SGTC_291 SEC14.278 35.5 µM -0.772644452678021 0.219860714184124 no 2684 0.219866414457934 3769 1068044
SGTC_2409 alverine citrate 63.97 µM -0.774727851836328 0.21924744775337 no 2685 0.219250244819524 3973 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_2426 5582046 32.21 µM -0.775089085338227 0.219141215680947 no 2686 0.219143510316997 3776 2251934
SGTC_743 1275-0778 158 µM -0.775166330196992 0.219118503242138 no 2687 0.219120690476714 3808 2849257 YMR203W TOM40
SGTC_553 k007-0256 45.7 µM -0.776031300791331 0.218864266900634 no 2688 0.218865252352649 3850 6287000
SGTC_814 3342-0569 96 µM -0.776285763498409 0.218789506310917 no 2689 0.218790138520612 3834 4346283
SGTC_2689 tacrolimus 100 µM -0.778077627466234 0.218263476817332 no 2690 0.218261625522283 3812 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12).
SGTC_423 5-fluorouracil 457 µM -0.78142534107148 0.217282658452377 no 2691 0.217276185779374 3783 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_701 4424-0219 185 µM -0.781865907065594 0.217153770548259 no 2692 0.217146691491204 3807 2911779
SGTC_752 1896-0090 130 µM -0.782376830181564 0.217004354943208 no 2693 0.216996573188815 3781 772567
SGTC_2273 7815444 169.05 µM -0.783258865036541 0.216746550385479 no 2694 0.216737556851974 3730 2824616
SGTC_3166 9102297 49.47 µM -0.783409248755598 0.216702613330216 no 2695 0.216693413360452 3796 25237072
SGTC_2636 apigenin dimethyl ether 100 µM -0.784115188165279 0.216496430478977 no 2696 0.216486262097962 3806 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_2175 5807670 165.306 µM -0.786122489539645 0.215910781090629 no 2697 0.215897864970966 3774 241186
SGTC_781 4335-2806 94.4 µM -0.786200748403931 0.215887966925727 no 2698 0.21587494385625 3937 845254
SGTC_1285 0929-0069 65.5 µM -0.786282143617249 0.215864239928785 no 2699 0.215851105637375 3824 1206237
SGTC_941 3237-0776 460 µM -0.786627741223372 0.215763513816971 no 2700 0.215749907445803 3823 760008
SGTC_1391 3442-0225 151 µM -0.786987126252307 0.215658798194804 no 2701 0.215644701184816 3763 5227075
SGTC_2826 7992541 19.48 µM -0.787219051803443 0.215591236656627 no 2702 0.215576823166267 3866 2985066
SGTC_1016 4226-1401 38 µM -0.787484839168464 0.215513826029309 no 2703 0.215499049994786 3799 2901613
SGTC_460 trequinsin 123 µM -0.787737209069392 0.215440338164339 no 2704 0.215425218029247 3844 5537 A vasodilator.
SGTC_1619 st003326 88.7 µM -0.787750931707033 0.215436342671352 no 2705 0.215421203829714 3750 2849032
SGTC_532 1548-0774 215 µM -0.787972138778751 0.215371941793708 no 2706 0.215356501461387 3941 5932993
SGTC_1152 3909-8331 15.9 µM -0.789002855349005 0.215072012568652 no 2707 0.215055168836057 3785 16001939
SGTC_3152 9099253 49.47 µM -0.78924888369219 0.215000456408113 no 2708 0.214983278029492 3776 25236131
SGTC_1635 st007035 42.4 µM -0.790407322608848 0.214663715874153 no 2709 0.214644963560106 3806 3716403
SGTC_1659 st012954 42.1 µM -0.790613048509489 0.214603946557607 no 2710 0.214584915034661 3822 24207262
SGTC_1543 azetidyl-2-carboxylic acid 198 µM -0.791035437139747 0.214481260782767 no 2711 0.214461656286732 3811 16486 A toxic proline analog.
SGTC_2913 7966556 36.57 µM -0.796733498613366 0.212830208278148 no 2712 0.21280291224096 3708 2976516
SGTC_2251 lansoprazole 556 µM -0.79722047099322 0.21268944961843 no 2713 0.212661499520161 3750 3883 Gastric proton pump inhibitor. YBR192W RIM2
SGTC_3346 9158254 43.5805 µM -0.797703804018945 0.212549796672709 no 2714 0.212521197912863 3847 17639500
SGTC_2541 muurolladie-3-one 83.07 µM -0.802095999449353 0.211283184445643 no 2715 0.211248714478697 3872 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils. YMR203W TOM40
SGTC_1893 st059353 36.1 µM -0.802739393723154 0.211098015762553 no 2716 0.211062689288517 3864 3112488
SGTC_465 cgp-37157 41 µM -0.803754768535156 0.210805984763757 no 2717 0.210769308433594 3785 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange.
SGTC_2838 9002687 71.43 µM -0.805068031087996 0.2104286301737 no 2718 0.210390211319583 3838 6457060
SGTC_22 0964-0034 14.468 µM -0.805301771443281 0.210361508504534 no 2719 0.210322779904405 3871 138402
SGTC_275 trichlorophene 5.69 µM -0.805391076920229 0.210335866561603 no 2720 0.210297019648041 3884 62616
SGTC_3306 9127676 59.7925 µM -0.805905262968661 0.210188265976774 no 2721 0.21014873820087 3852 41905287
SGTC_2922 7999257 32.47 µM -0.809645474652928 0.209116444995264 no 2722 0.20907198205696 3814 2988377
SGTC_3046 9092212 49.47 µM -0.809715525228442 0.209096401567094 no 2723 0.209051846491059 3881 25236637
SGTC_1053 3366-3204 134 µM -0.809848031466727 0.209058490921547 no 2724 0.20901376158916 3866 3632071 YPR165W RHO1
SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM -0.810820038406915 0.208780519031776 no 2725 0.20873451261239 3848 676296 Flavone; oxidizing agent.
SGTC_1488 4013-0813 75.9 µM -0.811558740543188 0.20856941274456 no 2726 0.208522437159186 3807 2910057
SGTC_809 3998-0021 90 µM -0.811603446273245 0.208556640781456 no 2727 0.208509606581372 3792 715485
SGTC_1048 3161-0300 24.5 µM -0.811696115946596 0.208530167486184 no 2728 0.208483011798769 3847 2165101
SGTC_1558 st069300 45.6 µM -0.812531962097494 0.208291477707777 no 2729 0.208243227103702 3775 24208000
SGTC_2181 6316240 54.2555 µM -0.813480019140255 0.208020939427264 no 2730 0.207971448777766 3874 12779990
SGTC_2371 9071574 200 µM -0.819029483078189 0.206441505775663 no 2731 0.206384796256229 3840 45596039
SGTC_2325 6158266 200 µM -0.81922393644181 0.206386291529818 no 2732 0.206329330293884 3905 3623240
SGTC_3101 9120531 49.47 µM -0.8198742904955 0.206201689712744 no 2733 0.206143887211974 3869 24824904
SGTC_3042 9091578 49.47 µM -0.820162228470697 0.206119990313023 no 2734 0.206061815649008 3790 25236497
SGTC_1902 st060212 70.5 µM -0.820292684484702 0.206082981097251 no 2735 0.206024637877637 3874 688944
SGTC_1895 st058434 18.3 µM -0.820299302138131 0.2060811038326 no 2736 0.206022752063654 3876 5393175
SGTC_293 4049-0273 38.5 µM -0.820870633320279 0.205919069534022 no 2737 0.205859980028757 3755 1380311
SGTC_901 1112-0062 60.1 µM -0.822504662448164 0.205456062571586 no 2738 0.205394867098579 3862 1908457
SGTC_3141 9094609 49.47 µM -0.824626184372344 0.204855846372947 no 2739 0.204791925462968 3839 25236309 YDL196W YDL196W
SGTC_1052 3253-3998 198 µM -0.825445454091234 0.204624339790595 no 2740 0.20455936906603 3824 5450317
SGTC_213 1246-0773 967 nM -0.826400081777576 0.204354780642406 no 2741 0.204288588532703 3863 6251622
SGTC_3131 9127911 49.47 µM -0.82662858752654 0.204290288623081 no 2742 0.204223804454721 3896 45595681
SGTC_1881 5652484 16 µM -0.826848277818048 0.204228296050449 no 2743 0.204161531199914 3817 2255129
SGTC_550 4123-0385 25.7 µM -0.827138715691411 0.204146357004216 no 2744 0.204079221246894 3883 5731123
SGTC_1568 digitonin 820 nM -0.827599877505737 0.20401629313622 no 2745 0.203948568831914 3847 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1
SGTC_1990 st072050 59.8 µM -0.828495666602698 0.203763790206912 no 2746 0.203694924021975 3878 17233948
SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM -0.833757668473806 0.202284314759512 no 2747 0.202208776999961 3907 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair.
SGTC_2536 dehydroabietamide 32.04 µM -0.834563877367992 0.202058208372384 no 2748 0.201981653881194 3937 3983547
SGTC_1683 st010134 710 nM -0.835654629440248 0.201752540907993 no 2749 0.201674613144659 3889 3818134
SGTC_1994 st072947 40.9 µM -0.837996253340517 0.201097270810692 no 2750 0.201016403867747 3952 5286565 YDL195W SEC31
SGTC_1573 oleylamine 1.06 µM -0.838260811463852 0.201023318324804 no 2751 0.2009421200804 3891 5356789 An amine of the fatty acid oleic acid.
SGTC_690 glyoxal 20.3 µM -0.839013177130215 0.200813097157915 no 2752 0.200730957592927 3731 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins.
SGTC_484 loperamide 105 µM -0.839134066892306 0.20077933122646 no 2753 0.200697040528327 3863 3955 An opioid-receptor agonist.
SGTC_3136 9095672 49.47 µM -0.839341586099838 0.200721376618671 no 2754 0.200638826561642 3643 17217380
SGTC_2699 st077704 54.6 µM -0.843802782386702 0.199477912653406 no 2755 0.199389810226009 3904 645852
SGTC_52 0329-0193 875 nM -0.84408124325058 0.199400451641027 no 2756 0.199312004118547 4002 3739292
SGTC_539 4859-0462 2.54 µM -0.846369994084938 0.198764463441356 no 2757 0.198673186055948 3953 46499474 YNL221C | YBR257W POP1 | POP4
SGTC_2558 carylophyllene oxide 100 µM -0.84682870148039 0.198637147084933 no 2758 0.198545303954045 3984 6708694 An oxygenated terpenoid and antifungal agent.
SGTC_2355 9061122 103.12 µM -0.847006606623608 0.19858778192997 no 2759 0.198495719507093 3930 5302957
SGTC_2290 7904846 200 µM -0.847561497682682 0.198433858186124 no 2760 0.198341112240873 3960 2962154
SGTC_1643 st009866 20.2 µM -0.84778143886405 0.198372867631702 no 2761 0.198279850950788 3870 3156273 YOR207C RET1
SGTC_2303 7774051 200 µM -0.848220156645882 0.198251243257308 no 2762 0.19815768686233 3857 2953184
SGTC_1088 bifonazole 369 nM -0.849080808874896 0.198012778096934 no 2763 0.1979181641739 3840 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase.
SGTC_666 0272-0154 136 µM -0.850913630133325 0.19750552685237 no 2764 0.197408666380712 3922 6870312
SGTC_2952 9073731 13.78 µM -0.852797758313192 0.196984895693369 no 2765 0.196885733639885 3968 16457353
SGTC_2556 citropten 84.59 µM -0.854302857241328 0.196569597139086 no 2766 0.196468602237737 3952 2775 A potential DNA crosslinker.
SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM -0.854585268516872 0.196491731180794 no 2767 0.19639039293745 3884 4620898
SGTC_2387 9077560 195.08 µM -0.856216018000023 0.196042469381467 no 2768 0.195939152056708 3889 5303272
SGTC_1957 st077035 62.4 µM -0.857075469568183 0.19580594650586 no 2769 0.19570158855394 3927 705593
SGTC_480 am 92016 50 µM -0.858074836653729 0.195531136463638 no 2770 0.195425570562954 3870 2129 K+ channel blocker.
SGTC_2709 st078560 56 µM -0.858097427100118 0.195524927158709 no 2771 0.195419333978604 3878 17250903
SGTC_3112 9123419 49.47 µM -0.859334962341282 0.195184956008143 no 2772 0.195077870178679 3943 17015854
SGTC_2674 ligustilide 100 µM -0.859499538492288 0.195139771330379 no 2773 0.195032487257514 3970 5319022 A signalling regulator.
SGTC_2812 7970281 58.44 µM -0.860199583612566 0.194947643732013 no 2774 0.194839517087362 3970 2233435
SGTC_2207 7258803 200 µM -0.860687345239528 0.194813845418291 no 2775 0.194705132357619 3878 3666799
SGTC_1753 st043925 64 µM -0.861754148110792 0.194521404533441 no 2776 0.194411410766095 3971 670181
SGTC_1765 st044815 90.4 µM -0.861838018467582 0.194498424626858 no 2777 0.194388330281051 3956 645695
SGTC_368 fentichlor 4.58 µM -0.861853346248078 0.194494225097975 no 2778 0.1943841123726 3970 7329 A pesticide.
SGTC_640 3381-0960 37.1 µM -0.863560488732533 0.194026845010047 no 2779 0.193914688559534 3954 1745025
SGTC_326 k292-0812 17.5 µM -0.865015149401428 0.193629129668378 no 2780 0.193515236937117 3892 3579357
SGTC_1205 4161-2785 76 µM -0.865626346620787 0.193462172109421 no 2781 0.193347551277546 4025 3498106
SGTC_259 usnic acid 108.925 µM -0.865665498389712 0.193451480218598 no 2782 0.193336812775125 3997 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_1451 4152-0210 104 µM -0.869515498543908 0.192401851444302 no 2783 0.192282617328768 3906 659563
SGTC_3280 9140961 49.47 µM -0.871001221831475 0.191997730432671 no 2784 0.191876742977229 3972 4901226
SGTC_1515 3460-0031 42.1 µM -0.871259514872393 0.191927527025088 no 2785 0.19180623526024 3861 2876596
SGTC_1146 3579-1023 7 µM -0.871736667605348 0.191797879426107 no 2786 0.191676025897516 3986 X1146
SGTC_247 mechlorethamine 29.705 µM -0.871843286933331 0.191768917123522 no 2787 0.191646938139675 3830 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links.
SGTC_1565 sinapyl alcohol 95.1 µM -0.872448953667689 0.191604443333539 no 2788 0.191481752170182 3977 5280507 A phenol propionate derived from cinnamic acid.
SGTC_1628 st004252 77.7 µM -0.873739618628283 0.191254240999177 no 2789 0.191130034960223 3970 692968
SGTC_1778 st046819 58.9 µM -0.875602754590885 0.190749399888744 no 2790 0.19062301369859 3988 671715
SGTC_2911 7942208 15.64 µM -0.876297595042433 0.190561333314026 no 2791 0.19043413606561 3975 1243384
SGTC_226 1,3-diallylurea 8.28947 mM -0.879805275602854 0.18961367805462 no 2792 0.189482403119278 3915 74537 YKL182W FAS1
SGTC_110 0850-0284 111.64 µM -0.881186560904084 0.189241299027904 no 2793 0.189108425991343 3743 3906265
SGTC_2471 5466956 24.79 µM -0.881974146974141 0.189029176352398 no 2794 0.188895394039982 3905 724419
SGTC_3006 9075424 71.4286 µM -0.882052438756101 0.18900809782221 no 2795 0.188874225197973 3897 7465181
SGTC_849 0386-0493 241 µM -0.883269967525147 0.188680488385587 no 2796 0.188545213094859 3906 726119
SGTC_2584 androsterone 48.74 µM -0.883737394340847 0.18855480745282 no 2797 0.188418994550918 3927 2754130 A steroid.
SGTC_778 3456-2434 196 µM -0.884634546729728 0.188313727293087 no 2798 0.188176883918818 3951 5539063
SGTC_80 0159-0065 512.242 µM -0.88949361990265 0.187011318082049 no 2799 0.186868925284042 3847 1548079
SGTC_1422 4031-0024 15.5 µM -0.891099694518612 0.186582059674476 no 2800 0.18643784440376 3910 782427
SGTC_2482 5981709 142.65 µM -0.891862116886368 0.186378499430981 no 2801 0.186233421061706 3935 877755
SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM -0.893029637654667 0.186067048149669 no 2802 0.185920650650338 4011 6710655
SGTC_244 nsc-207895 1.295 µM -0.895097939959643 0.185516094327227 no 2803 0.185367367548342 3769 42640
SGTC_3203 9113543 49.47 µM -0.896296060447442 0.185197402936566 no 2804 0.185047331306664 4064 17018012
SGTC_2416 tofa 880 nM -0.896696799292922 0.185090885225294 no 2805 0.184940364507504 4007 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_1584 6-fluoro-dl-tryptophan 90 µM -0.897185358792009 0.184961075986491 no 2806 0.184810008258575 4009 94937 An inhibitor of serotonin biosynthesis.
SGTC_341 1486-1430 230 µM -0.897538510234094 0.184867279618322 no 2807 0.184715816826356 3947 2054753 YPL210C SRP72
SGTC_3127 9126946 49.47 µM -0.901282893567968 0.183874597491556 no 2808 0.183718963376166 3977 27243249
SGTC_445 e6 berbamine 66 µM -0.902252975878807 0.183617959177679 no 2809 0.183461249572819 4015 6610268 A calcium/calmodulin antagonist.
SGTC_506 n9-isopropylolomoucine 153 µM -0.904415880199785 0.183046560188952 no 2810 0.182887460375356 3982 6610355
SGTC_2750 bromebric acid 70.15 µM -0.906259686748363 0.182560337836227 no 2811 0.182399208856686 4043 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2
SGTC_1060 3448-7350 82 µM -0.907923449555521 0.182122287053759 no 2812 0.181959333697602 3946 570178
SGTC_3223 9129970 49.47 µM -0.908126748492453 0.182068805724364 no 2813 0.181905629875835 4004 17248386
SGTC_1591 genipin 88.4 µM -0.909818389129144 0.181624171008964 no 2814 0.181459147463892 4029 442424 A DNA cross-linking agent.
SGTC_2620 irigenin 100 µM -0.910137250554442 0.181540436913422 no 2815 0.181375065821949 4038 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro.
SGTC_1706 st031321 9.9705 µM -0.910693591728803 0.181394397693744 no 2816 0.181228420767102 4003 6103185
SGTC_2924 9010168 62.78 µM -0.911574052893142 0.181163427533337 no 2817 0.18099649325829 4095 2993929
SGTC_1114 scopoletin 1.73284 µM -0.912846541584008 0.180829943008596 no 2818 0.180661628245634 4003 5280460 A coumarin with genotoxic properties.
SGTC_454 lyso-paf C-16 6.67 µM -0.915610861500991 0.180106817219447 no 2819 0.179935516242255 3942 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_1062 mesoridazine 14.2 µM -0.918207102132084 0.179429315333815 no 2820 0.179255225582168 3998 4078 A neuroleptic.
SGTC_2450 5739737 12.93 µM -0.918614683872599 0.179323100546339 no 2821 0.179148574383481 4038 2262825
SGTC_2386 9075165 157.42 µM -0.920169939410217 0.178918168189769 no 2822 0.178741980245537 3960 16452277
SGTC_2281 7943571 200 µM -0.920878966730953 0.178733754215222 no 2823 0.178556810510854 4096 1244024
SGTC_2057 5236571 38.335 µM -0.920933302092817 0.178719626835046 no 2824 0.178542625261328 3989 54684039 YBR257W POP4
SGTC_2735 sertaconazole 140 nM -0.921021199561166 0.178696774680837 no 2825 0.178519679507035 4106 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C
SGTC_2223 6903751 107.57 µM -0.922260861786801 0.178374675221872 no 2826 0.178196261836587 3956 5598863
SGTC_1504 k297-0033 30 µM -0.923945550766033 0.177937531923381 no 2827 0.177757332722689 3908 4388117
SGTC_1297 1068-0111 14.1 µM -0.923948099770481 0.177936871019697 no 2828 0.177756669121899 3949 767057
SGTC_2256 7954252 200 µM -0.925535945876316 0.177525476503814 no 2829 0.177343597385559 4029 2972920
SGTC_2012 4023501 200 µM -0.925633053237021 0.17750033648545 no 2830 0.177318354980728 4028 3477460
SGTC_2354 9060492 162 µM -0.927674783515621 0.176972275580118 no 2831 0.176788146333468 4082 6471895
SGTC_1794 st048918 76.9 µM -0.928467359656085 0.176767556175239 no 2832 0.176582595764033 3894 672303
SGTC_413 propylparaben 100 µM -0.932605227916479 0.175701193012176 no 2833 0.175511916560902 3954 7175 A pharmaceutical preservative.
SGTC_875 0709-0210 25.7 µM -0.934451277674843 0.175226768113807 no 2834 0.175035578736061 4016 6251364
SGTC_3326 9140064 16.379 µM -0.93748295134662 0.174449408673774 no 2835 0.174255094679507 3947 1868434
SGTC_385 1494-0393 12.4 µM -0.938840683250861 0.174101980352815 no 2836 0.173906273807769 4005 3090647
SGTC_216 k038-0035 28.382 µM -0.93960916554695 0.17390552943835 no 2837 0.173709036569312 3944 4444231 YPR107C YTH1
SGTC_1751 st044839 27.194 µM -0.939672164891985 0.173889430859467 no 2838 0.173692873588262 3992 5291326
SGTC_365 0121-0052 13.6 µM -0.943796500197294 0.172837578422751 no 2839 0.172636824701222 4076 3101739
SGTC_1777 st045864 34.765 µM -0.944538217963535 0.172648845048995 no 2840 0.172447340762434 3999 4691462
SGTC_1233 0325-0408 14.2 µM -0.945148509041138 0.172493652350787 no 2841 0.172291531435863 4062 12874
SGTC_97 0535-0701 19.132 µM -0.945406641335828 0.172428037918323 no 2842 0.172225656446655 3932 2832013 YGL099W LSG1
SGTC_2649 anisomycin 9.56 µM -0.945968266671501 0.172285333850361 no 2843 0.172082386004201 4013 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_1448 4255-0083 152 µM -0.946104341849269 0.172250769685731 no 2844 0.172047684722152 4105 5399660
SGTC_1278 0874-0585 172 µM -0.9467679184993 0.172082279405329 no 2845 0.171878526388554 4073 766306
SGTC_1741 st038134 10.228 µM -0.947415671449224 0.171917908458009 no 2846 0.171713504288528 4104 1272587
SGTC_2655 perillic acid 100 µM -0.949743076952773 0.17132814378415 no 2847 0.171121407901268 4056 5702197 An apoptosis inducer.
SGTC_673 1082-0474 110 µM -0.950641594421222 0.171100805866039 no 2848 0.170893173112601 4045 3098046
SGTC_1687 st020778 55.3625 µM -0.952836649540058 0.170546236972372 no 2849 0.170336420941341 4044 4259299
SGTC_1107 amlodipine 47 µM -0.954134722175062 0.170218828044176 no 2850 0.170007726082811 3789 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.
SGTC_3093 9117344 49.47 µM -0.954862128574474 0.170035532719118 no 2851 0.169823711837832 4072 24824913
SGTC_1478 0453-0656 35.7 µM -0.95659464338298 0.169599475101007 no 2852 0.169385946783603 4037 5258496
SGTC_1014 4130-3005 69.3 µM -0.956621046485458 0.169592835244051 no 2853 0.169379280958758 4050 743608
SGTC_2567 aureobasidin a 60 nM -0.957138013355109 0.169462861923028 no 2854 0.16924879951294 4205 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1
SGTC_2791 5663188 71.43 µM -0.957393570812761 0.169398634513012 no 2855 0.169184321141842 4098 54690634
SGTC_1324 1418-0026 34.4 µM -0.957762218850787 0.169306012390613 no 2856 0.169091337264486 4087 1372513
SGTC_3079 9117512 49.47 µM -0.958151088707159 0.169208344813257 no 2857 0.168993288424748 4079 7185044
SGTC_2800 7887935 81.82 µM -0.961854142461326 0.168280107987386 no 2858 0.168061438284314 4068 2961002
SGTC_346 4513-0042 7.16 µM -0.961969375867749 0.16825127531491 no 2859 0.168032493673172 4018 2827372
SGTC_102 gallobenzophenone 83.616 µM -0.962512985652387 0.168115300995482 no 2860 0.167895991695532 4047 70837
SGTC_3321 9137793 26.8275 µM -0.96307637553826 0.167974453671724 no 2861 0.167754598225628 4008 4904192
SGTC_3352 9151559 45.5865 µM -0.963295583033016 0.167919672386108 no 2862 0.167699604637596 4053 17159339
SGTC_2942 9052777 62.25 µM -0.965546230359433 0.167357887240095 no 2863 0.167135646083102 4105 6469503
SGTC_2132 5317594 122.667 µM -0.965696616309601 0.167320392550774 no 2864 0.167098006580845 4008 794577
SGTC_833 3852-0053 558 µM -0.967583405660093 0.166850432519591 no 2865 0.16662623406624 4127 3123681
SGTC_2338 7999974 200 µM -0.96812027548027 0.166716865168892 no 2866 0.166492152473193 4059 315925
SGTC_2184 6075246 200 µM -0.968192904508312 0.166698801159194 no 2867 0.16647401894606 4063 2267320
SGTC_573 3702-0553 84.7 µM -0.970863819569152 0.166035378879438 no 2868 0.16580804853704 3994 1222756
SGTC_2695 st077686 51.995 µM -0.971538014099331 0.165868187329448 no 2869 0.165640216358142 4093 2876092
SGTC_1608 st001473 40.5 µM -0.973210572241432 0.165453884499766 no 2870 0.165224328716147 4031 7292267
SGTC_1482 3346-2049 8.48 µM -0.973629940082241 0.165350109593002 no 2871 0.165120157442625 4056 3826804
SGTC_2173 5763948 167 µM -0.974052515859703 0.165245583473453 no 2872 0.165015232329915 4042 2867177
SGTC_3353 9151644 39.2805 µM -0.974435176608 0.1651509674283 no 2873 0.164920255330345 4098 4909158
SGTC_2830 7992007 71.43 µM -0.974744913217817 0.165074408166504 no 2874 0.164843404146127 3944 1952075
SGTC_1799 st045822 46.1415 µM -0.975118400646083 0.164982121834269 no 2875 0.16475076609807 4030 3674992
SGTC_3313 9133968 57.047 µM -0.976070085150354 0.164747117786486 no 2876 0.164514867279463 4057 1494643
SGTC_200 k038-0079 37.545 µM -0.978662407992835 0.164108083431317 no 2877 0.163873406099699 4031 3436683
SGTC_1929 genistein trimethyl ether 50.5 µM -0.979800033439356 0.163828155303199 no 2878 0.163592417808491 4049 136420
SGTC_3020 9089140 49.47 µM -0.985198396336885 0.162504042194834 no 2879 0.162263314100199 4117 17217859
SGTC_658 3253-0951 102 µM -0.986412511829751 0.162207205260152 no 2880 0.161965363896856 4077 1184878
SGTC_1582 3',3',6'-trihydroxyflavone 74 µM -0.986949892062073 0.162075934905014 no 2881 0.161833601868388 4038 688803
SGTC_712 r015-0009 80.6 µM -0.987437589579203 0.161956860866213 no 2882 0.161714082182017 4098 6813872 YLR060W FRS1
SGTC_2090 5301565 104.445 µM -0.989085467273274 0.161554944138778 no 2883 0.161310663662585 4080 2056344
SGTC_898 1000-0849 28.3 µM -0.991922921416117 0.160864415304233 no 2884 0.160617563390495 4074 6751807
SGTC_138 0850-0259 40.9225 µM -0.99415811943362 0.160321811585692 no 2885 0.16007294691739 4045 6813004
SGTC_173 1273-0061 2.693 µM -0.994523836310827 0.160233146271068 no 2886 0.159983953362415 4063 2847414 YPL266W DIM1
SGTC_1274 0865-0114 173 µM -0.995480214047105 0.160001431195807 no 2887 0.159751381349974 4079 870624
SGTC_2300 7976697 71.57 µM -0.998801298572105 0.159198487908286 no 2888 0.158945478426471 3978 2236109
SGTC_255 tunicamycin 200.472 nM -0.999296239239774 0.159079051765454 no 2889 0.158825603354027 4017 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_260 nsc-65238 3.989 µM -0.999761637404241 0.158966798209921 no 2890 0.158712937575443 4074 3246252
SGTC_2063 5246145 200 µM -1.00009174133431 0.158887208956202 no 2891 0.158633056232597 4123 711240
SGTC_2375 9072683 200 µM -1.00065269354215 0.158752021252271 no 2892 0.158497372743007 4148 16798029
SGTC_2059 5238311 157 µM -1.00088259505477 0.158696637507542 no 2893 0.158441786011041 4084 703021
SGTC_518 1021-0119 62.6 µM -1.00196196044272 0.158436785547555 no 2894 0.158180982648952 4068 1097762
SGTC_1968 st069590 43.6 µM -1.00273320167923 0.158251284034633 no 2895 0.157994802947765 4088 6384066
SGTC_1884 5633444 25 µM -1.00529576758673 0.157635951031071 no 2896 0.157377226248925 4098 5724239
SGTC_505 gw-5074 63.9 µM -1.0053868506704 0.157614108784886 no 2897 0.157355304527521 4134 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases.
SGTC_2437 5741531 144.16 µM -1.0054277410017 0.157604303695527 no 2898 0.157345463765117 4128 2262990
SGTC_1427 4048-4900 550 nM -1.00965631922474 0.156592496936182 no 2899 0.156329988417208 4090 24132586
SGTC_1878 temozolomide 1 mM -1.01068908787794 0.156346029070843 no 2900 0.156082630706615 4007 5394 DNA alkylating agent.
SGTC_2380 9035439 200 µM -1.01096165102298 0.156281025140128 no 2901 0.156017392335145 4206 6462575
SGTC_2564 betulinic acid 100 µM -1.01114530342494 0.156237235686208 no 2902 0.155973445010434 4167 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14
SGTC_3243 9134147 49.47 µM -1.01159775847235 0.156129388334675 no 2903 0.155865209046435 4163 24282180
SGTC_787 4152-0075 138 µM -1.01516396647275 0.155281063080947 no 2904 0.155013837000028 4115 9566539
SGTC_145 3737-0113 38.366 µM -1.01664628815312 0.154929346936527 no 2905 0.154660862895324 4062 6849351
SGTC_2848 9016370 25.97 µM -1.01831789034083 0.154533351193238 no 2906 0.154263454518386 4105 7894410
SGTC_513 4245-1575 41.7 µM -1.01876102310977 0.154428487128457 no 2907 0.154158217030669 4011 719745
SGTC_2271 7849410 118.62 µM -1.01961231784866 0.154227166604356 no 2908 0.153956180374706 4033 972430
SGTC_1930 st074634 34.3 µM -1.02029165069434 0.154066637489641 no 2909 0.15379508096118 4019 684253 YOR116C RPO31
SGTC_1906 st060206 94.7 µM -1.02031230524551 0.154061758467358 no 2910 0.153790184615758 4144 5133468
SGTC_2872 9044037 25.97 µM -1.0221380282933 0.153630889653784 no 2911 0.153357788358384 4112 6465195
SGTC_720 r052-1644 49.9 µM -1.02698353625358 0.152491226985824 no 2912 0.152214108283343 4147 1422863 YOR257W CDC31
SGTC_763 3453-1109 128 µM -1.02699736837943 0.152487981723189 no 2913 0.152210851628264 4136 1560353
SGTC_1896 st058441 89 µM -1.02849857042754 0.152136045431827 no 2914 0.151857681475716 4124 688759
SGTC_486 niguldipine 82 µM -1.03408049800836 0.150832173571435 no 2915 0.150549266242889 4169 1236 A calcium channel blocker.
SGTC_855 0428-0020 25 µM -1.0347270638175 0.150681625679656 no 2916 0.150398196611883 4153 6812414
SGTC_2551 apiole 73.87 µM -1.03603133321795 0.150378241155535 no 2917 0.150093762480602 4016 10659 A possible DNA adduct former.
SGTC_1170 0310-0127 64.8 µM -1.03604300981467 0.150375526915971 no 2918 0.15009103886159 4148 774975
SGTC_1490 4089-0339 670 nM -1.03706694680984 0.150137638411054 no 2919 0.149852329050645 4089 742542
SGTC_396 dithiazanine 1.25 µM -1.03966942612982 0.14953414108224 no 2920 0.14924675485129 4131 10578 An antihelmenthic.
SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM -1.03982026141889 0.149499213104296 no 2921 0.149211706967407 4134 66535 A nucleotide analog.
SGTC_847 0342-0274 5.54 µM -1.04184595808387 0.149030662904397 no 2922 0.148741551391581 4134 18097
SGTC_2612 dictamnine 15.46 µM -1.04378760669883 0.148582475023711 no 2923 0.148291833376847 4096 68085 A quinoline derivative and established mutagen. YOR116C RPO31
SGTC_1880 MG-132 525 µM -1.04418697837856 0.148490400506793 no 2924 0.148199445178652 4093 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1
SGTC_1081 sertraline 6 µM -1.04441290124812 0.148438331242555 no 2925 0.148147198624431 4130 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1
SGTC_3308 9128332 17.569 µM -1.04558854283778 0.148167573970535 no 2926 0.147875520627862 4148 17332805 YDL196W YDL196W
SGTC_2373 9071805 200 µM -1.04614826311975 0.148038783240072 no 2927 0.14774629262965 4152 10149009
SGTC_961 1252-1571 372 µM -1.04672331203741 0.147906543468467 no 2928 0.147613604345297 4164 6813498
SGTC_2824 7998404 51.95 µM -1.04787886844922 0.147641047843695 no 2929 0.147347209674447 4106 837851
SGTC_1085 doxorubicin 7.67 µM -1.04840783753664 0.14751962077058 no 2930 0.147225372049155 4168 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_134 0269-0018 6.916 µM -1.04979203853297 0.147202188312881 no 2931 0.146906868222667 4117 4378915
SGTC_2448 5185112 27.17 µM -1.04995978159751 0.147163751695681 no 2932 0.146868302063571 4179 5718189
SGTC_2496 diffractaic acid 79.83 µM -1.0499624547379 0.147163139227219 no 2933 0.146867687531248 4166 94870 An apoptosis inducer which activates caspases.
SGTC_1816 st051957 91.6 µM -1.05031637016493 0.147082065408372 no 2934 0.146786340604693 4128 674121
SGTC_1984 st072354 53.1 µM -1.05229089861407 0.146630296411701 no 2935 0.146333053048058 4033 5762938
SGTC_1009 4106-0057 9.87 µM -1.05245954889783 0.146591752704239 no 2936 0.146294380039434 4150 2928005
SGTC_2197 6588183 93.1375 µM -1.05342074318366 0.146372209063881 no 2937 0.14607410068044 4094 884136
SGTC_1956 st077085 54 µM -1.0536557973669 0.146318554620425 no 2938 0.146020266635204 4191 24208685
SGTC_2120 5538279 151.968 µM -1.05368457957692 0.146311985581384 no 2939 0.146013675612529 4113 2058197
SGTC_2115 tiliquinol 12.7705 µM -1.05436603741007 0.146156512528475 no 2940 0.145857682607122 4122 71208 A bioactive hydroxyquinoline.
SGTC_148 3253-0744 288.01 µM -1.05608931342974 0.145763846301442 no 2941 0.145463706140475 4024 6893655
SGTC_2962 9082311 13.18 µM -1.05620742384772 0.14573695961437 no 2942 0.145436729894203 4134 16459453
SGTC_1131 3454-3128 32.3 µM -1.05703689553435 0.145548232379093 no 2943 0.145247374573847 4190 710982
SGTC_715 0868-0130 184 µM -1.06164139285827 0.144503573946401 no 2944 0.14419925741911 4203 2876258
SGTC_2675 theaflavin digallate 100 µM -1.06207322853783 0.144405859770483 no 2945 0.14410122128382 4094 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative.
SGTC_170 4197-0004 226 µM -1.06318628636117 0.144154206514736 no 2946 0.143848740087641 4180 218692
SGTC_340 k038-0059 454 µM -1.06341221954571 0.144103160995657 no 2947 0.1437975268458 4137 23733424
SGTC_3038 9091290 49.47 µM -1.06409176496725 0.143949703457593 no 2948 0.143643565526773 4192 25236843
SGTC_3207 9114163 49.47 µM -1.06465526127439 0.143822536199465 no 2949 0.143515981298442 4193 849233
SGTC_2261 9010538 184.68 µM -1.06472356171921 0.143807127620452 no 2950 0.143500522227074 4168 6457250
SGTC_478 N-arachidonylglycine 10 µM -1.0651543444537 0.143709968709878 no 2951 0.143403045091103 4114 5283389
SGTC_2489 cantharidin 73.42 µM -1.06628687860617 0.143454747849354 no 2952 0.143146989576026 4113 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_2326 6164455 177.58 µM -1.07242281616662 0.142077313125662 no 2953 0.141765082222403 4134 2888790
SGTC_1701 st028638 40.4 µM -1.07382378564033 0.141764074027829 no 2954 0.141450833611567 4181 3490878
SGTC_2128 5255449 168.493 µM -1.07757429061121 0.14092781193369 no 2955 0.140611890316898 4124 736008
SGTC_2073 5212005 126 µM -1.08280030236844 0.139768141569063 no 2956 0.139448535661598 3991 691789
SGTC_1345 1488-0192 31.4 µM -1.0859254750821 0.139077762953205 no 2957 0.138755982550292 4232 658348
SGTC_1829 berberine 14.4 µM -1.08652714157007 0.138945116360754 no 2958 0.138622919782105 4165 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_894 0960-0238 55.9 µM -1.08668002961056 0.138911423580112 no 2959 0.138589121374709 4174 6741907 YDL195W SEC31
SGTC_545 4218-0007 221 µM -1.08811720003406 0.138594978340623 no 2960 0.138271685736174 4178 2840508
SGTC_2956 9076196 2.52 µM -1.08961958729296 0.138264698695535 no 2961 0.137940375593763 4200 16423868
SGTC_1976 st070609 63.5 µM -1.09159479981497 0.137831291806242 no 2962 0.137505621421592 4101 682556
SGTC_1715 st032160 10.2275 µM -1.09245246623738 0.137643389065886 no 2963 0.137317136331903 4121 5289825
SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM -1.0948337966447 0.137122589754526 no 2964 0.136794728552868 4239 368090
SGTC_1629 st005085 44.9 µM -1.09656391591408 0.136745056346389 no 2965 0.136416034312083 4137 24207091
SGTC_1856 st057054 55.7 µM -1.09751359471654 0.136538127058698 no 2966 0.136208470611388 4209 1266018
SGTC_2162 5663267 200 µM -1.09866953796148 0.136286543105503 no 2967 0.135956117110413 4193 6456493
SGTC_1563 conessine 56.1 µM -1.09920957488484 0.136169116157399 no 2968 0.135838331641611 4278 441082 An anti-amoebic, histamine inhibitor.
SGTC_2222 6885208 172.143 µM -1.10094288053446 0.135792689815919 no 2969 0.135460758884525 4155 609514
SGTC_3005 9076496 71.4286 µM -1.10177111001352 0.135613072997652 no 2970 0.135280596582602 4162 21368410
SGTC_2085 5307070 144.047 µM -1.10701728693002 0.134479124149288 no 2971 0.134143227183966 4146 2840351
SGTC_627 1391-0720 175 µM -1.10846123724397 0.134168163349676 no 2972 0.133831335406551 4178 997839
SGTC_1986 st071812 45 µM -1.10917849612319 0.134013882373395 no 2973 0.133676593662848 4146 11838594
SGTC_923 1900-2434 73.3 µM -1.11189468360111 0.13343074089837 no 2974 0.133091717408801 4173 5910570
SGTC_1396 3511-0007 98.6 µM -1.11249169714009 0.133302801692652 no 2975 0.132963399042133 4223 X1396
SGTC_363 0455-0021 3.06 µM -1.11425528904757 0.132925359319036 no 2976 0.132584841118782 4164 4597466
SGTC_2668 2',4'-dihydroxychalcone 15.08 µM -1.11496021790501 0.132774697102186 no 2977 0.132433734883245 4259 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_514 4466-0038 2.65 nM -1.11572570822905 0.132611224513614 no 2978 0.132269781344873 4027 5722064
SGTC_2233 sulbentine 40.3845 µM -1.11603603097542 0.132544993741241 no 2979 0.132203355960151 4209 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58
SGTC_3170 9103054 49.47 µM -1.12038900682164 0.131618359523763 no 2980 0.131274013746683 4192 16432970
SGTC_3256 9138902 49.47 µM -1.12052142469403 0.131590241482584 no 2981 0.131245813967601 4306 17228773
SGTC_942 3253-1115 227 µM -1.12210710558565 0.131253854913519 no 2982 0.130908451531043 4256 46497897
SGTC_49 0717-0965 32.132 µM -1.12254532732127 0.131160995323328 no 2983 0.130815323201572 4297 5889349 YGL099W LSG1
SGTC_3085 9117376 49.47 µM -1.12349281749351 0.130960376432873 no 2984 0.130614124673456 4315 16480349
SGTC_647 0140-0236 81 µM -1.12496573746465 0.13064892571555 no 2985 0.130301776707783 4230 990837
SGTC_2724 maprotiline 69.64 µM -1.12600211011835 0.130430090619201 no 2986 0.130082313080892 4137 4011 A tricyclic antidepressant.
SGTC_1999 st074831 12.5 µM -1.12681053874528 0.130259563113468 no 2987 0.129911296884631 4188 17112523
SGTC_320 4092-0846 5.34 µM -1.12798229906068 0.130012669436341 no 2988 0.129663697370178 4177 1359356
SGTC_3264 9137442 49.47 µM -1.1310542495565 0.129366937963474 no 2989 0.129016129382237 4218 17015726
SGTC_2277 7947813 106.88 µM -1.13225002427383 0.129116185165721 no 2990 0.128764667162793 4276 1246798
SGTC_1483 3453-0561 55.9 µM -1.13316038461744 0.128925509552845 no 2991 0.128573453503172 4242 4546991
SGTC_1006 4099-6547 255 µM -1.13735950482575 0.1280485292942 no 2992 0.12769401431684 4252 3146833
SGTC_1873 rapamycin 2 nM -1.13798878516201 0.127917462887613 no 2993 0.127562582648444 4185 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1
SGTC_3066 9117245 49.47 µM -1.14316633125916 0.126842622762268 no 2994 0.126484769164166 4296 17176980
SGTC_1519 esterone 74 µM -1.14342877404031 0.12678830851081 no 2995 0.126430305710464 4188 698 A steroid.
SGTC_649 1123-0311 367 µM -1.14668858531522 0.126115018781966 no 2996 0.125755174879214 4133 693629 YIL048W NEO1
SGTC_2428 5615643 7.78 µM -1.14969035340995 0.125497233872675 no 2997 0.125135714454447 4256 2253075
SGTC_160 3453-0671 289.699 µM -1.15067306790515 0.125295444003462 no 2998 0.124933380184457 4272 5322268
SGTC_1495 4469-0029 237 µM -1.16181506531231 0.123023390989512 no 2999 0.122655296597353 4263 793680
SGTC_1801 st050089 28.441 µM -1.16251846248782 0.122880931230099 no 3000 0.12251246484437 4299 5008493 YIL048W | YNL267W NEO1 | PIK1
SGTC_2503 beta-caryophyllene alcohol 24.72 µM -1.16326268189299 0.122730329685632 no 3001 0.122361470840846 4280 61125 An anti-inflammatory.
SGTC_2871 9038510 12.99 µM -1.16352152494994 0.12267798010689 no 3002 0.122308985033598 4230 4945164
SGTC_1793 st048256 72.231 µM -1.16530389030562 0.122317931811382 no 3003 0.12194800247259 4175 672022
SGTC_2017 5132927 60.65 µM -1.16756452211362 0.121862338725449 no 3004 0.121491233935533 4250 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis
SGTC_2657 nystatin 74.44 µM -1.16870640082959 0.121632665587021 no 3005 0.121260971095355 4286 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_2321 7390090 138.78 µM -1.17089800130823 0.121192708034444 no 3006 0.120819889309467 4286 649046
SGTC_1833 st055984 71 µM -1.17202534228699 0.120966834013853 no 3007 0.120593440868593 4258 676288
SGTC_2769 toremifene 3.73 µM -1.17614115308139 0.12014470563821 no 3008 0.119769237648968 4309 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_1940 st075990 51.1 µM -1.17759356762398 0.119855529558321 no 3009 0.119479337728669 4344 1084979
SGTC_2697 mebhydrolin 72.4 µM -1.1799098720313 0.119395368758115 no 3010 0.119018031537281 4335 22530 H1 Histamine receptor antagonist. YIL048W NEO1
SGTC_322 k048-0136 19.3 µM -1.18018477535692 0.119340838882667 no 3011 0.118963366457102 4327 6823282
SGTC_1292 0kpi-0043 232 µM -1.18521751187881 0.118345649149923 no 3012 0.117965728895737 4297 3333905
SGTC_327 1273-0057 3.96 µM -1.18682797312932 0.118028433876272 no 3013 0.11764774127745 4164 3108138
SGTC_2193 5925765 200 µM -1.19079691248083 0.117249234058217 no 3014 0.116866660636408 4277 877370
SGTC_1179 1021-1431 9.29 µM -1.19089107783182 0.117230791453504 no 3015 0.116848173797905 4291 2840958
SGTC_1489 4065-0444 182 µM -1.19219881521947 0.116974879039486 no 3016 0.116591648944366 4279 2877968
SGTC_1311 1190-0148 100 µM -1.19292858485409 0.116832241932847 no 3017 0.116448671583491 4331 1961333
SGTC_2227 7312221 64.1025 µM -1.19866285288571 0.115715740254271 no 3018 0.115329533897182 4387 887188 YOR168W | YOR169C GLN4 | YOR169C
SGTC_3088 9117578 49.47 µM -1.19917156569893 0.115617057576514 no 3019 0.115230620580863 4337 678341
SGTC_674 0498-0004 451 µM -1.20172993596617 0.115121678372319 no 3020 0.114734089389058 4259 4231473
SGTC_1065 prochlorperazine maleate 2.48 µM -1.20261218102296 0.114951199038326 no 3021 0.114563215855358 4327 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine.
SGTC_2272 7805186 180 µM -1.20269779543643 0.114934665024985 no 3022 0.11454664367169 4305 2956062 YPR165W RHO1
SGTC_20 0481-0013 4.944 µM -1.2029615928645 0.114883730615086 no 3023 0.114495591743108 4333 182045
SGTC_2701 st077767 14.721 µM -1.20345240898647 0.114789005821587 no 3024 0.114400648669349 4259 5721188
SGTC_530 4358-1714 28 µM -1.20386126961664 0.114710140417935 no 3025 0.114321601803357 4285 1564641
SGTC_1632 st005650 90 µM -1.20571717878511 0.114352637554497 no 3026 0.113963279465288 4318 2759605
SGTC_313 3474-0040 5.03 µM -1.20578711520548 0.114339181264052 no 3027 0.11394979242972 4298 1043375 YIL048W NEO1
SGTC_1655 st012546 55.1 µM -1.20796039556112 0.113921587618384 no 3028 0.113531248264878 4289 720985 YLR208W SEC13
SGTC_2601 securinine 100 µM -1.21095683211103 0.113347609131898 no 3029 0.112955974744344 4275 442872 A GABA receptor antagonist.
SGTC_266 formosanin C 406 nM -1.21416560478331 0.112735247275077 no 3030 0.112342245959388 4147 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1
SGTC_2098 5376439 882.5 nM -1.21524337851302 0.112530095987251 no 3031 0.112136640143618 4328 2844116
SGTC_3078 9116413 49.47 µM -1.21614431221695 0.112358810453518 no 3032 0.111964976432599 4227 17177322
SGTC_1520 flindersine 88 µM -1.22135388818796 0.111372018333298 no 3033 0.110976029102068 4359 68230 Flindersine is a natural alkaloid of the quinoline subtype.
SGTC_868 0527-0199 213 µM -1.22556454676757 0.110578985116429 no 3034 0.110181293127467 4264 2849450
SGTC_1879 gemcitabine 100 µM -1.2276383266793 0.110189901556887 no 3035 0.109791383775871 4276 60750 A nucleoside analog which inhibits DNA replication.
SGTC_2813 7971799 71.43 µM -1.22769538667546 0.110179209832412 no 3036 0.109780669449171 4306 2234054
SGTC_1301 naphtanilide LB 4.81 µM -1.23115296291033 0.109532728042882 no 3037 0.109132829979793 4367 67238 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_1469 k284-2957 126 µM -1.23260027645825 0.10926292630197 no 3038 0.108862466871692 4314 23884841
SGTC_1022 4477-0945 21.3 µM -1.23380821715101 0.109038113190239 no 3039 0.10863718836975 4260 4648966
SGTC_2216 7189485 200 µM -1.23493906755374 0.108827949049144 no 3040 0.108426591118486 4311 731273
SGTC_2966 9084041 48.03 µM -1.23607528296796 0.108617081327835 no 3041 0.108215290740909 4241 17741380
SGTC_2445 5742597 35.57 µM -1.23612065977141 0.108608666053564 no 3042 0.108206858239907 4316 1774255
SGTC_1044 1222-0021 1.78 µM -1.23641399541876 0.108554277327814 no 3043 0.108152358249615 4254 4306703
SGTC_1963 st076565 50.3 µM -1.23693010369057 0.108458630861573 no 3044 0.108056516425591 4336 4914280
SGTC_2404 5161160 200 µM -1.23871367623663 0.108128561621899 no 3045 0.107725776050638 4263 2831543
SGTC_656 4090-1979 187 µM -1.2426776011809 0.107397585606768 no 3046 0.106993330542236 4352 22330961
SGTC_2389 9091542 195.52 µM -1.24338238814859 0.107267991709669 no 3047 0.106863478550347 4297 3626624 YOL127W RPL25
SGTC_1425 4048-4433 7.33 µM -1.24679047689798 0.106642914309975 no 3048 0.106237166612686 4375 23734946
SGTC_2790 5423970 71.43 µM -1.24811273084416 0.106401109014771 no 3049 0.10599488836495 4365 1376240 YKL165C | YIL048W MCD4 | NEO1
SGTC_1732 st034308 51.822 µM -1.24879072527745 0.106277275411424 no 3050 0.105870813554191 4195 830119
SGTC_2712 st079126 47.7 µM -1.251946063349 0.105702332004163 no 3051 0.105294759175767 4309 3152970
SGTC_2357 9067248 200 µM -1.25387960397338 0.105351128945908 no 3052 0.104942884740909 4299 9150235
SGTC_1015 4130-4525 82 µM -1.25715171231661 0.104758716505165 no 3053 0.104349352373306 4337 1363237
SGTC_2604 4'-hydroxychalcone 11.32 µM -1.26016665445659 0.104215002648113 no 3054 0.103804624619059 4347 5282362
SGTC_1908 st060353 56.5 µM -1.26026878743115 0.104196619902687 no 3055 0.103786207829007 4387 4227716
SGTC_772 k072-0172 35.3 µM -1.26526927038309 0.103299463973335 no 3056 0.102887409165595 4395 5861980
SGTC_3035 9091303 49.47 µM -1.26579196384748 0.103206010272859 no 3057 0.102793786474129 4411 25237002
SGTC_2659 sanguinarine 24.21 µM -1.27594569933915 0.101402762464842 no 3058 0.100987357449251 4293 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis.
SGTC_845 0330-0138 4.51 µM -1.27688208085449 0.101237629365941 no 3059 0.100821940661446 4294 9039800
SGTC_483 fpl-64176 144 µM -1.27727526563485 0.101168348742664 no 3060 0.100752541402986 4466 3423
SGTC_554 4483-2211 187 µM -1.28169124460696 0.100392608853196 no 3061 0.0999754887515237 4414 747107
SGTC_1909 st060837 51.5 µM -1.28346010374479 0.100083100054991 no 3062 0.0996654642183108 4313 678937
SGTC_1092 toremifene 6.32 µM -1.28812769411316 0.0992697273275982 no 3063 0.0988507582109754 4349 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_2931 9014674 55.67 µM -1.28841919662715 0.0992190910160357 no 3064 0.0988000399580436 4320 2996810
SGTC_2465 5809242 33.21 µM -1.2886790728205 0.0991739643753483 no 3065 0.0987548403972192 4407 2731748
SGTC_83 0170-0301 39.027 µM -1.28982235382264 0.0989756156705693 no 3066 0.0985561723590954 4360 3089716
SGTC_548 1436-0017 110 µM -1.28984730676649 0.0989712898034707 no 3067 0.098551839548943 4399 9677137
SGTC_769 0302-0231 76 µM -1.29139728155937 0.0987028556965556 no 3068 0.0982829763953492 4265 571869 YER009W NTF2
SGTC_794 k038-0031 316 µM -1.29165042509307 0.0986590654207983 no 3069 0.0982391164633998 4345 6624242
SGTC_1840 st055363 71 µM -1.29222574051019 0.098559596821169 no 3070 0.0981394899913373 4392 676033
SGTC_3197 9113331 49.47 µM -1.29435631756227 0.0981918721532402 no 3071 0.0977711859156507 4351 16610459 YLR208W | YDL195W SEC13 | SEC31
SGTC_82 0054-0107 293.755 µM -1.29450938669366 0.0981654920987062 no 3072 0.0977447645517496 4311 3104697
SGTC_2525 harmine 47.85 µM -1.29508084799414 0.0980670518828381 no 3073 0.0976461704890953 4341 5280953 A monoamine oxidase inhibitor
SGTC_2974 9094440 9.66 µM -1.29535874990501 0.0980192065053898 no 3074 0.0975982505099783 4351 25236134
SGTC_989 1501-0895 10.3 µM -1.29654311446441 0.0978154904809396 no 3075 0.097394218117042 4328 2830112
SGTC_113 0099-0221 2.5 µM -1.2973589984652 0.0976753354186826 no 3076 0.0972538465926584 4331 89219
SGTC_3288 9119690 36.221 µM -1.29844413412933 0.097489155704443 no 3077 0.0970673808462762 4345 17595618 YKL019W RAM2
SGTC_1156 4092-0367 4.88 µM -1.2987635679313 0.0974343991868439 no 3078 0.0970125405340252 4406 1357585
SGTC_1121 fusaric acid 630.51 nM -1.30120865703614 0.0970160153790626 no 3079 0.0965935214199141 4335 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler.
SGTC_2092 5303694 80.6725 µM -1.30197376370979 0.0968853678161684 no 3080 0.0964626772711243 4367 1963699
SGTC_1208 2323-2347 50.3 µM -1.31715966742877 0.0943189311242003 no 3081 0.0938925550464615 4373 5412760
SGTC_410 α-linolenic acid 100 µM -1.31980408233566 0.0938771952442934 no 3082 0.0934502191379972 4409 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_3163 9099914 49.47 µM -1.32078879542213 0.0937130947659571 no 3083 0.0932858983618532 4449 16268368
SGTC_504 lovastatin 124 µM -1.32242359272544 0.0934411268520049 no 3084 0.0930135684654064 4402 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1
SGTC_2633 5,7-dihydroxyisoflavone 100 µM -1.32382038110396 0.0932092167747392 no 3085 0.0927813528082363 4383 5377381
SGTC_2495 cafestol 54.53 µM -1.32478105194868 0.0930499627301047 no 3086 0.092621890570708 4392 16667697 An anti-infammatory.
SGTC_482 fipronil 114 µM -1.32626306433656 0.0928046785079123 no 3087 0.092376288325618 4495 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels.
SGTC_724 3910-0327 137 µM -1.32775791246977 0.0925577545530201 no 3088 0.0921290474622001 4421 2885483
SGTC_664 1222-0054 14.9 µM -1.32902705723516 0.0923484947941102 no 3089 0.0919195216876383 4350 6813991
SGTC_1141 3253-0389 52.6 µM -1.3296743766769 0.0922418980718942 no 3090 0.0918127903604252 4376 5402031
SGTC_1685 st024049 53.0905 µM -1.33245334271624 0.0917853090843141 no 3091 0.0913556317383026 4407 1941139
SGTC_1854 st056233 32.9 µM -1.33862340784221 0.0907775455088303 no 3092 0.0903466509235505 4315 5393174
SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM -1.33921622440179 0.0906811541690646 no 3093 0.090250146065507 4400 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_2714 st079313 56.9 µM -1.34127446958724 0.0903470754316968 no 3094 0.0899156778482742 4381 2939799
SGTC_229 benomyl 22.8748 µM -1.34384168942497 0.0899316658640634 no 3095 0.0894997925878701 4415 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C
SGTC_406 estrone 100 µM -1.34425794777416 0.0898644437998946 no 3096 0.089432494446823 4368 5870 A steroid.
SGTC_617 3770-0098 35 µM -1.34861824738826 0.089162536919413 no 3097 0.0887298082687564 4317 5962639
SGTC_3233 9132340 49.47 µM -1.34968920603858 0.0889907632203531 no 3098 0.0885578480647378 4406 17682950
SGTC_881 0833-0569 170 µM -1.35253951019048 0.0885347963030055 no 3099 0.0881013941554962 4413 5418700
SGTC_2451 5856223 45.7 µM -1.3536985973357 0.0883498742082463 no 3100 0.087916277914586 4392 2179896
SGTC_1089 terbinafine 2.25 µM -1.35589162275784 0.0880007841480343 no 3101 0.0875668266600791 4415 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_2718 lomofungin 53.02 µM -1.35765706608491 0.0877205055174055 no 3102 0.0872862630761945 4383 5351222 A RNA synthesis inhibitor.
SGTC_1245 0418-0076 17.2 µM -1.36040731952626 0.0872852077950527 no 3103 0.0868505317495584 4427 6790114
SGTC_3279 9140807 49.47 µM -1.36108411332477 0.0871783355985892 no 3104 0.086743554769043 4453 45595718
SGTC_1174 0739-0097 51.1 µM -1.36313379505038 0.0868552673847879 no 3105 0.0864201738257572 4446 728447
SGTC_1692 fluoroquinolonic acid 71 µM -1.36648590414029 0.0863288412097571 no 3106 0.0858932510966389 4425 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2
SGTC_988 1497-1057 103 µM -1.36655023745734 0.0863187614829012 no 3107 0.0858831620202276 4398 3533044
SGTC_1852 st056254 31.4 µM -1.36956404073563 0.0858475454091445 no 3108 0.0854115155333553 4373 442583
SGTC_3167 9103034 49.47 µM -1.37130923045628 0.0855755620822406 no 3109 0.0851392897403445 4502 5127859
SGTC_1477 0139-0234 16 µM -1.37245772221925 0.0853969249592686 no 3110 0.0849604957539442 4420 620880
SGTC_162 k030-0015 37.8 µM -1.37590436569357 0.0848625088476158 no 3111 0.0844256217212947 4471 1809920 YMR134W ERG29
SGTC_3186 9110464 49.47 µM -1.37627080879073 0.0848058381448556 no 3112 0.0843689034617298 4403 17018021
SGTC_473 2-arachidonoylglycerol 10 µM -1.3778198192976 0.0845665959662126 no 3113 0.0841294626433741 4250 5282280 An endocannabinoid.
SGTC_1384 3089-0840 101 µM -1.38745660760763 0.083089569793933 no 3114 0.0826512869761691 4434 1069836
SGTC_401 neomycin 50 µM -1.39258548180757 0.0823114223980281 no 3115 0.0818725878845822 4435 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis.
SGTC_789 1309-1135 70.6 µM -1.39335866478605 0.0821945934716001 no 3116 0.0817556793791021 4403 3092424
SGTC_3037 9091026 49.47 µM -1.39536784164484 0.0818915883286796 no 3117 0.0814524718217241 4306 25236398 YIL048W NEO1
SGTC_1740 st038286 13.222 µM -1.39553736551194 0.0818660608949789 no 3118 0.0814269275981154 4450 716786
SGTC_960 1222-0186 7.7 µM -1.39800858035342 0.0814946182479357 no 3119 0.0810552452869426 4424 3126296
SGTC_586 0957-0265 8.15 µM -1.39858117388783 0.081408734663983 no 3120 0.0809693075281617 4324 6752309 YPR165W | YPR107C RHO1 | YTH1
SGTC_2723 salbutamol 83.58 µM -1.40419624998252 0.0805701406043291 no 3121 0.0801302091204885 4438 9884233 β2-adrenoceptor agonist
SGTC_3172 9105863 49.47 µM -1.40731079965841 0.0801078144503252 no 3122 0.0796676241641302 4533 2348785
SGTC_476 mead acid 10 µM -1.40749468616471 0.0800805810240446 no 3123 0.0796403759227773 4503 5312531 An omega 9 fatty acid.
SGTC_3147 9097027 49.47 µM -1.40773628911548 0.0800448104840961 no 3124 0.0796045859963849 4439 25236841
SGTC_1663 st014140 55.4 µM -1.40881084900352 0.0798858627837176 no 3125 0.079445553153216 4509 4207120
SGTC_2264 7948757 110.76 µM -1.41131090470346 0.0795169811642059 no 3126 0.0790764802565249 4411 2971411
SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM -1.41270000860658 0.0793125776073647 no 3127 0.0788719745282745 4484 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_2698 st077697 67.5 µM -1.41667679827593 0.0787296011971299 no 3128 0.078288721767534 4414 3154499
SGTC_3187 9109394 49.47 µM -1.41885051276525 0.0784123216417126 no 3129 0.0779713012325181 4442 17098090
SGTC_2858 9025781 8.96 µM -1.42070717352935 0.078142088317466 no 3130 0.0777009531032614 4290 4894980 YPL153C RAD53
SGTC_3324 9138759 60.749 µM -1.421161776125 0.0780760295899404 no 3131 0.0776348670516009 4474 45595710
SGTC_2691 st077356 60.2 µM -1.42425998918254 0.077626953105098 no 3132 0.077185612552727 4447 2839272
SGTC_754 3474-0146 171 µM -1.42574160617509 0.077412891638586 no 3133 0.0769714710000944 4448 24762078
SGTC_1914 st062367 72.6 µM -1.42962767308952 0.0768535696370973 no 3134 0.0764119543679332 4435 978205
SGTC_566 0958-0068 16.5 µM -1.43157719564928 0.0765741344572962 no 3135 0.0761324299224195 4365 6815365
SGTC_2905 7799065 20.05 µM -1.43294117734706 0.0763790878378225 no 3136 0.0759373241605875 4341 1296806
SGTC_1937 st074714 47.2 µM -1.43658670718855 0.0758596398670889 no 3137 0.0754177314462613 4391 17250970
SGTC_1090 efavirenz 20.7 µM -1.43934503652354 0.0754683994542432 no 3138 0.0750263943438689 4492 64139 A non-nucleoside reverse transcriptase inhibitor.
SGTC_676 falcarinol 140 µM -1.45093712156809 0.073840976970995 no 3139 0.0733986849719147 4489 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer.
SGTC_400 oxethazaine 37.5 µM -1.45385114364689 0.0734361243527468 no 3140 0.0729937902592242 4497 4621 A local anesthetic.
SGTC_2244 6635614 200 µM -1.45602370631545 0.0731353908795846 no 3141 0.0726930331676684 4420 836499
SGTC_1546 5-methoxyflavanone 78.7 µM -1.46155542438998 0.0723739266335189 no 3142 0.0719315385258934 4497 147795
SGTC_1652 st011932 78 µM -1.46682640367773 0.0716540202229583 no 3143 0.0712116425512117 4411 1551076
SGTC_2455 5377712 9.75 µM -1.46894194462242 0.0713666310185634 no 3144 0.0709242682554899 4467 2243908
SGTC_3012 9080433 71.4286 µM -1.46907211322478 0.0713489769819731 no 3145 0.0709066153357604 4472 17688859
SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM -1.469910599449 0.0712353381351871 no 3146 0.0707929842365319 4521 91467 include heat shock
SGTC_1217 1183-1422 255 µM -1.47307536599361 0.0708076735417295 no 3147 0.070365357491399 4506 2849664
SGTC_461 N-acetylfarnesylcysteine 136 µM -1.4791579146642 0.0699912626402058 no 3148 0.0695490572806742 4546 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ).
SGTC_1941 st076221 61.8 µM -1.47974423935499 0.0699129493614046 no 3149 0.0694707572922491 4360 2828568
SGTC_1206 3978-0017 132 µM -1.48100009470572 0.069745436186992 no 3150 0.0693032741266352 4525 3873677
SGTC_1030 k029-0042 36.7 µM -1.48152624494222 0.0696753471576766 no 3151 0.0692331982936449 4470 6080581
SGTC_2783 7738165 71.43 µM -1.48282330415652 0.0695027961292525 no 3152 0.0690606813669137 4466 17201110
SGTC_1458 k015-0034 6.33 µM -1.48485143573237 0.0692336485156743 no 3153 0.0687915915421928 4515 3598957
SGTC_3156 9099931 49.47 µM -1.49023709436546 0.0685228302822208 no 3154 0.0680809530482079 4533 18111053
SGTC_909 3448-9333 149 µM -1.49076414480025 0.0684535718333683 no 3155 0.0680117142288922 4416 3344074
SGTC_857 0438-0306 1.35 µM -1.49378280541621 0.0680579367853023 no 3156 0.0676161985705418 4530 4686136
SGTC_2533 agelasine 13.65 µM -1.49503597058998 0.0678942125401252 no 3157 0.0674525273591582 4524 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase.
SGTC_985 1493-0307 8.71 µM -1.49679166085069 0.0676653458886728 no 3158 0.0672237384182254 4527 3278274
SGTC_256 clotrimazole 625 nM -1.50163879454285 0.0670365816829599 no 3159 0.0665952093000368 4434 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C
SGTC_962 1254-0300 21.5 µM -1.50237237104788 0.0669418180123222 no 3160 0.0665004838220379 4473 7340576
SGTC_2528 xanthyletin 44.79 µM -1.50372865094026 0.0667668862374038 no 3161 0.0663256244606677 4525 65188 An natural product with antifungal activity of unknown mechanism.
SGTC_137 0438-0332 85.389 µM -1.50436859728631 0.0666844694469809 no 3162 0.0662432426477922 4442 2063393 YER012W | YPR107C PRE1 | YTH1
SGTC_1180 1193-0155 285 µM -1.50574814002418 0.0665070700517026 no 3163 0.0660659204162783 4545 2921347
SGTC_2652 actinonin 100 µM -1.51385648322822 0.0654717694113671 no 3164 0.0650311216092378 4547 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase.
SGTC_2587 piperic acid 92.2 µM -1.52097221962729 0.0645735446599184 no 3165 0.0641334044398613 4442 5370536
SGTC_85 0868-0259 160.055 µM -1.52311075151926 0.0643054752729177 no 3166 0.0638654997140568 4449 83173
SGTC_1084 voriconazole 435 nM -1.52835894002985 0.0636512697134339 no 3167 0.0632117217225177 4528 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_496 calpeptin 138 µM -1.52890087432211 0.0635840116909944 no 3168 0.0631445097396106 4500 73364 A calpain inhibitor.
SGTC_1046 2001-0062 216 µM -1.529481319582 0.0635120355245929 no 3169 0.0630725832745466 4460 739778
SGTC_1182 1222-0449 220 µM -1.5320705725623 0.0631917359359032 no 3170 0.0627525102946433 4511 658318
SGTC_2882 9058044 58.44 µM -1.53375266594348 0.0629843300584785 no 3171 0.0625452559065693 4526 18076804
SGTC_2152 5568786 200 µM -1.53455404614586 0.062885704765042 no 3172 0.0624467039647611 4539 5399883
SGTC_2139 5578692 56.4705 µM -1.53825962406931 0.0624312256147634 no 3173 0.0619925738406165 4489 650991 YMR113W FOL3
SGTC_1812 st052057 4.327 µM -1.539071794851 0.0623319580672118 no 3174 0.0618933849456652 4544 3645418
SGTC_379 3970-0972 5.9 µM -1.53920990991134 0.0623150892114066 no 3175 0.0618765295420533 4511 2898042 YBL034C STU1
SGTC_1333 1482-0047 286 µM -1.54011330009042 0.0622048403113317 no 3176 0.0617663691804944 4549 3811116
SGTC_1602 st001878 87.6 µM -1.54662198614488 0.0614150176670166 no 3177 0.0609772124503712 4495 595405 YLR310C CDC25
SGTC_391 gliotoxin 8.33 µM -1.55030851445955 0.0609711487481137 no 3178 0.060533742341757 4556 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion
SGTC_1656 st012921 11 µM -1.55463534369995 0.0604533892279226 no 3179 0.0600164706268349 4443 6732821
SGTC_2568 diosmetin 100 µM -1.55965543398503 0.0598569907492961 no 3180 0.0594206645263292 4528 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.
SGTC_1372 2752-0194 270 µM -1.57154949177443 0.058462345389355 no 3181 0.0580275339688096 4460 823334
SGTC_390 dec-rvkr-cmk 16.7 µM -1.58006548769503 0.0574795676948199 no 3182 0.0570459349702521 4556 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1
SGTC_1707 st032323 6.317 µM -1.58247899355437 0.0572034167118844 no 3183 0.0567701320470463 4346 3132057 YMR211W DML1
SGTC_2510 benzyl isothiocyanate 8.31 µM -1.58429218308043 0.0569966410733773 no 3184 0.0565636219194689 4549 2346 DNA damaging agent; causes G2/M arrest.
SGTC_768 0384-0033 77.3 µM -1.5869687228157 0.0566924852564148 no 3185 0.0562598643094719 4498 3965305 YMR134W ERG29
SGTC_1350 1495-0454 146 µM -1.5891616822038 0.056444236590908 no 3186 0.0560119474471435 4563 1069057
SGTC_21 0849-0113 22.993 µM -1.59140605060898 0.0561910561846207 no 3187 0.0557591117583251 4525 1560156
SGTC_3198 9112019 49.47 µM -1.59386367785471 0.0559148466940794 no 3188 0.0554832856631182 4583 45595555
SGTC_1315 1237-0019 3.69 µM -1.59797240115332 0.0554554660477649 no 3189 0.0550245597067506 4551 825140
SGTC_2765 myclobutanil 7.74 µM -1.60141154388694 0.0550732440569698 no 3190 0.0546428987962291 4553 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11
SGTC_587 k089-0003 57 µM -1.6030694573734 0.0548897306863914 no 3191 0.0544596601299894 4471 9659696
SGTC_2422 chlorphenesin carbamate 384.24 µM -1.60389583160748 0.054798440512657 no 3192 0.0543685079010175 4497 2724 A muscle relaxant with antifungal properties.
SGTC_705 1124-0212 310 µM -1.60391773851222 0.0547960220746227 no 3193 0.0543660931290691 4538 9554485
SGTC_1798 st045719 60.953 µM -1.61582209316421 0.0534942588881639 no 3194 0.0530663917073238 4525 3980186
SGTC_907 3448-6986 75.5 µM -1.62840936191902 0.0521445963800005 no 3195 0.0517190569250379 4569 590582
SGTC_603 3794-0023 45.9 µM -1.62958549634947 0.052019880281573 no 3196 0.0515945658927402 4595 3802260
SGTC_105 0111-0055 734.78 µM -1.63134324805618 0.051833931954075 no 3197 0.0514089563048655 4567 5179370
SGTC_1978 st071761 42 µM -1.64233405784621 0.0506831902529359 no 3198 0.0502603963083406 4570 5147680
SGTC_1287 0971-0001 34.6 µM -1.65586120884804 0.0492949264343876 no 3199 0.0488749644173306 4568 4665869
SGTC_2039 Aminomethylbenzodioxan 200 µM -1.65652663766995 0.0492274262423669 no 3200 0.0488076076066766 4599 15053
SGTC_2592 piperlongumine 83.33 µM -1.65841500740917 0.0490362744672348 no 3201 0.0486168647679782 4558 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_2493 resveratrol 26.09 µM -1.66031009950907 0.0488450387907454 no 3202 0.0484260425105991 4547 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase.
SGTC_984 1492-0255 2.91 µM -1.66278633901626 0.0485960576139549 no 3203 0.0481776060714354 4536 1585198
SGTC_2006 4011487 200 µM -1.66834818612281 0.0480405232429656 no 3204 0.0476233137819886 4526 45595294
SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM -1.67062824196156 0.0478142582017841 no 3205 0.0473975652661685 4549 1241132 A phosphatase inhibitor.
SGTC_382 3229-0966 23.2 µM -1.67236196434122 0.0476427811603743 no 3206 0.0472264838104943 4599 5722370
SGTC_1718 roemerine 11.9335 µM -1.67449708448155 0.0474322803029056 no 3207 0.0470164734598921 4186 235224 An aporphine alkaloid with mutagenic activity.
SGTC_3239 9133757 49.47 µM -1.67806373081459 0.0470823084342387 no 3208 0.0466673291073322 4647 17036923
SGTC_1677 st019204 53.9 µM -1.68062358720174 0.0468324048348701 no 3209 0.0464180256550387 4584 3945625
SGTC_3098 9119039 49.47 µM -1.68776194573403 0.0461411461818151 no 3210 0.0457284676222641 4567 17161528
SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM -1.69007712740111 0.0459187185983649 no 3211 0.0455066000422781 4585 23847180
SGTC_415 dibenzyl ketone 100 µM -1.69049134104202 0.0458790146553486 no 3212 0.0454669967217912 4563 7593
SGTC_268 camptothecin 39.6153 µM -1.6919820083458 0.0457363567883363 no 3213 0.0453247020518808 4539 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_2597 laccaic acid a 100 µM -1.6924549484013 0.0456911706830974 no 3214 0.0452796315287916 4548 5491415 A textile dye.
SGTC_2214 7179297 48.276 µM -1.69649843114899 0.0453063076128144 no 3215 0.044895763514271 4651 769744
SGTC_792 4534-1957 155 µM -1.70263087341257 0.0447275961150572 no 3216 0.0443185843180727 4570 1717904
SGTC_930 2810-3379 265 µM -1.70413617140544 0.0445864566522389 no 3217 0.0441778251934351 4574 1015764
SGTC_3109 9122853 49.47 µM -1.7146148194794 0.0436138737691723 no 3218 0.0432079349474365 4615 1234709
SGTC_1459 k035-0031 35.7 µM -1.71642686160516 0.0434474371638365 no 3219 0.043041971828266 4346 3877128 YMR208W ERG12
SGTC_3311 9131146 2.8755 µM -1.71676653416123 0.0434162952769942 no 3220 0.0430109189516805 4559 4900406 YPR165W RHO1
SGTC_2180 6301957 200 µM -1.7175993461173 0.0433400175951678 no 3221 0.0429348598439102 4614 845462
SGTC_310 1273-0058 1.06 µM -1.72105949142603 0.0430242590336299 no 3222 0.0426200145205131 4288 2734232
SGTC_764 1951-2361 146 µM -1.72306149533458 0.0428424148670832 no 3223 0.042438702478523 4599 5438930
SGTC_2334 9017922 200 µM -1.72930526378208 0.0422792730200366 no 3224 0.0418772375288515 4601 3163164
SGTC_2492 derrusnin 100 µM -1.73307245077777 0.0419424073444321 no 3225 0.0415413961153808 4627 1715307 Part of coumarin class of compounds.
SGTC_964 1287-0107 19.4 µM -1.73308956718246 0.0419408817517189 no 3226 0.0415398751976581 4592 51516812 YPR165W RHO1
SGTC_24 0417-1663 219 µM -1.74450079643927 0.0409337492749612 no 3227 0.0405359013266858 4625 4329390
SGTC_1470 k295-0292 231 µM -1.7474706657866 0.0406748769228093 no 3228 0.040277864484726 4654 5045612
SGTC_2635 hydroquinidine 100 µM -1.7477177572502 0.0406533988936651 no 3229 0.0402564562151962 4545 442912 An experimental heart treatment.
SGTC_107 0358-0022 2.6945 µM -1.75168443143008 0.0403098603696681 no 3230 0.0399140426905489 4630 521106 YGL093W | YPR107C SPC105 | YTH1
SGTC_3145 9085516 49.47 µM -1.75538353525203 0.0399916231906354 no 3231 0.0395968632115664 4589 25236195
SGTC_207 4185-0010 4.486 µM -1.75575615751027 0.039959679674838 no 3232 0.0395650266956554 4648 3761753
SGTC_1731 st035964 63 µM -1.76329890937946 0.0393175140304244 no 3233 0.0389250445819556 4525 6739575
SGTC_304 1310-0298 97 µM -1.76637887505655 0.0390577217250961 no 3234 0.0386661533869344 4358 1550234
SGTC_1116 jasmonic acid 1.58368 µM -1.77565512492408 0.0382837110698705 no 3235 0.0378948890573302 4657 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid.
SGTC_2021 4019055 173 µM -1.78098879447011 0.0378443621512003 no 3236 0.0374571406712667 4401 44827708 YER133W GLC7
SGTC_1797 st048695 56.8 µM -1.7844190029193 0.037563986828071 no 3237 0.037177802746144 4595 592262 YIL048W NEO1
SGTC_3057 9095946 49.47 µM -1.80229648537907 0.0361300648973913 no 3238 0.0357493856055899 4659 24540043
SGTC_1800 st050079 29.0735 µM -1.80660956679015 0.0357909159297038 no 3239 0.0354115884020048 4453 3645560
SGTC_106 0092-0003 11.579 µM -1.81843383527329 0.0348745023842227 no 3240 0.0344989254285013 4578 1072148
SGTC_1465 k213-0056 144 µM -1.82642179528893 0.0342663832521172 no 3241 0.0338933756585042 4570 24048857 YMR208W ERG12
SGTC_3049 9092223 49.47 µM -1.82712263916575 0.0342134468620073 no 3242 0.0338406660219795 4610 8623917
SGTC_1819 st053448 58.6 µM -1.8299693092011 0.0339991217862667 no 3243 0.0336272641203913 4592 2857616
SGTC_1032 k061-1018 98.7 µM -1.83038775521072 0.0339677103708115 no 3244 0.0335959886959848 4656 4005393
SGTC_1282 0886-0010 32.4 µM -1.8365908033423 0.0335048601957517 no 3245 0.0331351630012972 4648 2836211 YNL267W PIK1
SGTC_128 0906-2981 13.371 µM -1.83902080892917 0.0333249625564102 no 3246 0.032956062734865 4632 6740226
SGTC_585 0kpi-0023 191 µM -1.841924185588 0.0331110641792988 no 3247 0.0327431201653922 4590 64601
SGTC_3259 9138485 49.47 µM -1.84497762179277 0.0328873322037209 no 3248 0.0325203969884623 4611 17646153
SGTC_816 0325-0417 81.3 µM -1.8483514305963 0.0326415764050822 no 3249 0.032275760040218 4657 68101
SGTC_599 1935-0052 86.5 µM -1.85193960527875 0.0323818696219164 no 3250 0.0320172479521875 4635 9557311
SGTC_1555 citronellol 128 µM -1.8546202542596 0.0321889628574083 no 3251 0.0318252368588926 4632 8842 A terpine precursor.
SGTC_299 1273-0059 1.44 µM -1.85972095970605 0.0318245219972722 no 3252 0.0314625075240945 4403 2848077
SGTC_2777 climbazole 1.536 µM -1.86043730946825 0.0317736134713699 no 3253 0.0314118401158586 4433 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2
SGTC_490 phenamil 164 µM -1.86512663404137 0.0314420185518413 no 3254 0.0310818280458658 4668 4755 Irreversibly blocks amiloride-sensitive Na+ channels.
SGTC_897 1000-0139 31.4 µM -1.88997548392023 0.0297323011309576 no 3255 0.029380619495384 4616 6151020
SGTC_48 0382-0018 55 µM -1.89589987557944 0.0293362677951765 no 3256 0.0289866427041616 4660 762596
SGTC_1142 3253-1408 9.78 µM -1.91457433592474 0.0281164853965071 no 3257 0.0277734053342425 4658 256655
SGTC_1540 guanosine 70.6 µM -1.91663622858351 0.0279844330153053 no 3258 0.0276420810459548 4623 6802 Guanosine is a purine nucleoside
SGTC_569 4130-2812 160 µM -1.91917382344374 0.0278226240758343 no 3259 0.0274811695745001 4588 743552
SGTC_481 bay k-8644 50 µM -1.92093617185287 0.0277107077462139 no 3260 0.0273698774229685 4639 2303 A calcium channel antagonist.
SGTC_2686 alizarin 95.37 µM -1.9234252384549 0.027553281155579 no 3261 0.0272133336154019 4636 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1
SGTC_3103 9120822 49.47 µM -1.92819692949678 0.0272535692907269 no 3262 0.0269153179933283 4658 17141819
SGTC_2703 st077852 53.4 µM -1.92972233617952 0.0271583334263276 no 3263 0.026820625433753 4666 6281836
SGTC_1647 st011722 22.4 µM -1.93004659157141 0.0271381249839382 no 3264 0.026800532546014 4668 2854783
SGTC_1367 1812-0510 76.9 µM -1.94020885687829 0.0265111161609717 no 3265 0.026177156287831 4685 1142582 YDR527W RBA50
SGTC_215 1287-0124 461.5 µM -1.94181119979719 0.0264133654928319 no 3266 0.0260799802691854 4712 5560863
SGTC_457 grayanotoxin iii 135 µM -1.94540905910663 0.0261949757929753 no 3267 0.0258628826503907 4475 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity.
SGTC_995 3931-2021 34.6 µM -1.9460033619074 0.0261590473686897 no 3268 0.025827167887342 4651 730143
SGTC_3220 9131269 49.47 µM -1.95177317867404 0.0258123718265752 no 3269 0.0254825699956621 4686 17722206
SGTC_2138 5575593 77.673 µM -1.95456225290067 0.0256461755920934 no 3270 0.0253173801623503 4677 762213
SGTC_602 3130-1533 38.1 µM -1.96561337430168 0.024996439335807 no 3271 0.024671644004607 4688 720941
SGTC_1842 st055362 61.2 µM -1.96769566922841 0.0248755717397999 no 3272 0.0245515322166397 4665 676032
SGTC_329 k048-0121 21.3 µM -1.96799386309462 0.0248583031494249 no 3273 0.0245343719128317 4688 6832902
SGTC_1684 st024538 14.6195 µM -1.97750051607904 0.0243130136588252 no 3274 0.0239925411181927 4677 6732859
SGTC_54 0159-0055 9 µM -2.00441776153746 0.0228232864167682 no 3275 0.0225126641281351 4653 3319099
SGTC_1645 Cervolide 78 µM -2.02762141498773 0.0216015333948788 no 3276 0.0212994508268042 4710 23173 A fragrance.
SGTC_2454 5-benzylidenerhodanine 10.36 µM -2.02910377820177 0.0215253965828691 no 3277 0.0212238605848764 4702 1273210
SGTC_1395 3486-0190 4.35 µM -2.03348250224472 0.0213018207876475 no 3278 0.021001899804787 4685 6748079
SGTC_1726 st035556 14.5795 µM -2.04428537390125 0.020758615611785 no 3279 0.0204626816475226 4693 5919439
SGTC_528 3492-0019 172 µM -2.04860051692829 0.0205449377067298 no 3280 0.0202505970319335 4692 2869262
SGTC_3036 9090181 49.47 µM -2.05573691726385 0.0201956459872388 no 3281 0.0199039407201436 4739 25236586
SGTC_64 000l-0018 272.079 µM -2.05629281104551 0.0201686503833891 no 3282 0.019877150412062 4611 6811119
SGTC_306 1672-3436 11.6 µM -2.06490973977491 0.0197540885000401 no 3283 0.0194657706818872 4713 6797378
SGTC_2106 5357045 167.29 µM -2.07337367971132 0.0193539512814045 no 3284 0.0190687582433452 4710 668842
SGTC_2111 5486399 200 µM -2.07895910419534 0.019093686608356 no 3285 0.0188105547418876 4664 689674
SGTC_2429 5902844 64.44 µM -2.07999870355716 0.0190455742206505 no 3286 0.0187628258912818 4696 1927790 YGL093W | YPR107C SPC105 | YTH1
SGTC_392 N-ethylmaleimide 8.33 µM -2.08960539235073 0.0186058369401081 no 3287 0.0183266308745738 4695 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides.
SGTC_2276 7947513 42.08 µM -2.09311658998763 0.0184472864480829 no 3288 0.0181693740541866 4633 2105100
SGTC_1277 0873-0036 22 µM -2.09695672415885 0.0182752014596956 no 3289 0.0179987032059592 4740 5965735
SGTC_2526 patulin 37.61 µM -2.12833483784259 0.0169196466715595 no 3290 0.0166546658061766 4687 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.
SGTC_1605 st000082 49.1 µM -2.13324107135144 0.016715665361536 no 3291 0.0164524777603937 4697 1114022
SGTC_1225 1216-0074 20.6 µM -2.14201671047593 0.0163560549363744 no 3292 0.0160960686836118 4706 4241466
SGTC_2080 5212524 12.4 µM -2.15121385957911 0.0159863022275718 no 3293 0.015729661797408 4682 260183
SGTC_1648 st011736 69.8 µM -2.15701937996099 0.0157566109654142 no 3294 0.0155020772270991 4712 2855514
SGTC_2078 5212016 200 µM -2.16270034730307 0.0155345936517911 no 3295 0.0152821171892209 4661 1899708
SGTC_3130 9127414 49.47 µM -2.16900895328322 0.0152911991231894 no 3296 0.0150410020891728 4729 1494646
SGTC_3134 9127454 49.47 µM -2.17290402653004 0.0151425631610093 no 3297 0.0148937706835527 4709 24262820
SGTC_2202 7226349 200 µM -2.18651237864572 0.0146329732157996 no 3298 0.0143890700262551 4744 844334
SGTC_3222 9128301 49.47 µM -2.19019357107994 0.0144976862432637 no 3299 0.0142551006491804 4674 4911358
SGTC_635 k038-0028 24.7 µM -2.19251676987298 0.0144128619770891 no 3300 0.0141711067736917 4734 4035102
SGTC_2293 7624732 200 µM -2.23501082916857 0.0129350561842643 no 3301 0.0127083189042748 4640 894453
SGTC_1323 1348-1351 11.2 µM -2.24344227170222 0.0126579538112495 no 3302 0.0124341542811983 4721 6989654
SGTC_2364 9055074 200 µM -2.24923952606588 0.0124704188485606 no 3303 0.0122486304925536 4716 6470630
SGTC_2615 purpurogallin-4-carboxylic acid 100 µM -2.26200795999727 0.0120658405201499 no 3304 0.0118484557511876 4693 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase.
SGTC_135 0933-0004 26.348 µM -2.27756231255307 0.0115884047134447 no 3305 0.0113763340359967 4692 21230617 YGL099W LSG1
SGTC_1071 trifluoperazine 6.31 µM -2.28224766865041 0.0114478422734244 no 3306 0.0112373611119265 4754 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels.
SGTC_1353 1498-1206 8.11 µM -2.28371097602224 0.0114042471028977 no 3307 0.011194261283108 4739 6756808
SGTC_1373 2887-0003 58.5 µM -2.28790753068141 0.0112800214866351 no 3308 0.0110714533342119 4701 776948
SGTC_2516 gossypol 71.55 µM -2.31115254013898 0.0106130109807581 no 3309 0.0104122153843325 4748 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_631 k072-0230 41.5 µM -2.34320654878848 0.009749708759944 no 3310 0.00955939777280455 4748 5773147
SGTC_524 r073-0010 27.8 µM -2.36504455989498 0.00919728250751187 no 3311 0.00901395084459033 4715 2772106
SGTC_924 2046-0044 21.3 µM -2.37005880897521 0.00907437659274161 no 3312 0.00889262804525265 4729 3623589
SGTC_1437 4092-1038 11.6 µM -2.40100169515175 0.00834727486738499 no 3313 0.00817513037894603 4771 3977136
SGTC_1325 1431-0015 227 µM -2.42481172203254 0.00782311719441163 no 3314 0.00765816389582192 4758 1103340
SGTC_181 1447-1644 8.07 µM -2.42661623278475 0.00778459928722547 no 3315 0.00762018377973237 4720 534600
SGTC_2067 5224629 34.075 µM -2.42830371940336 0.00774873039314478 no 3316 0.00758481687202049 4734 2835000
SGTC_1416 3966-0321 25.3 µM -2.43469327279695 0.00761422986698312 no 3317 0.00745220892502052 4779 582530 YLR208W SEC13
SGTC_1754 st042065 16.137 µM -2.43675359126508 0.00757130049820384 no 3318 0.00740988705955419 4597 1126236 YIL048W NEO1
SGTC_2792 7535235 81.82 µM -2.43918758599078 0.00752085986834074 no 3319 0.00736016237413815 4711 1281891
SGTC_2950 9072895 21.46 µM -2.44849204564117 0.00733075797059932 no 3320 0.00717277987517534 4707 17332245
SGTC_1269 0831-0796 3.05 µM -2.45748222899092 0.00715111362675333 no 3321 0.00699573664574794 4751 927758
SGTC_1259 0671-0132 43 µM -2.49437592875778 0.00645391982954417 no 3322 0.00630894149986528 4730 X1259
SGTC_2079 5212404 121 µM -2.53329376286083 0.00578430811278702 no 3323 0.00564981057879064 4736 758462
SGTC_36 0335-0881 14.2 µM -2.53510685622741 0.00575467311697993 no 3324 0.00562065150006563 4720 23828853
SGTC_1432 4049-0298 68.4 µM -2.54165287754168 0.00564879681537571 no 3325 0.00551648425612117 4785 741646
SGTC_331 k048-0133 24.5 µM -2.55417637812173 0.00545104928000099 no 3326 0.00532196618207832 4769 6813582
SGTC_2457 5731572 11.68 µM -2.55948130479307 0.00536915575813551 no 3327 0.0052414247024977 4780 2865357
SGTC_1227 3909-8010 46.6 µM -2.57377926030207 0.0051538558159592 no 3328 0.00502972148174445 4779 15982272
SGTC_971 1315-0384 26.7 µM -2.59404895099757 0.00486180286291759 no 3329 0.0047426490471952 4779 6769120
SGTC_1042 0350-0096 82 µM -2.59534387601446 0.00484365650126525 no 3330 0.00472481614482803 4760 3122515
SGTC_775 4577-0580 57.3 µM -2.59643578013754 0.00482840210559583 no 3331 0.00470982562327068 4761 2006902
SGTC_1818 st052136 56.3 µM -2.64876265518505 0.00414575454580469 no 3332 0.00403935228351405 4591 674169
SGTC_1658 st012944 20 µM -2.65652425156261 0.00405221341051218 no 3333 0.00394753860551197 4675 24207260
SGTC_893 0958-0369 48.9 µM -2.66348150538922 0.00396997661486955 no 3334 0.00386683315013843 4652 6819948
SGTC_393 acivicin 6.25 µM -2.68836272932543 0.00368796614930883 no 3335 0.00359016756112407 4709 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1
SGTC_965 1291-5240 308 µM -2.69517564436335 0.00361394752695554 no 3336 0.00351757675849845 4755 2834598
SGTC_2190 6049624 200 µM -2.70792109471374 0.0034790464535786 no 3337 0.00338530587700651 4756 2265554
SGTC_3325 9138760 55.175 µM -2.78387670508633 0.00276482569207742 no 3338 0.00268567240394813 4757 43844959
SGTC_178 4092-0806 87.505 µM -2.84819266238963 0.00226662193129545 no 3339 0.00219841490364539 4709 2169044
SGTC_1002 4049-0206 172 µM -2.85645949297374 0.00220886314286894 no 3340 0.00214197331742279 4784 4662749
SGTC_2359 9039622 200 µM -2.92446999989855 0.00178201155599023 no 3341 0.00172521668498975 4772 6463596
SGTC_1369 1866-0067 208 µM -3.01015171741056 0.00135143556382762 no 3342 0.00130558611387926 4761 3531355
SGTC_963 1269-2853 151 µM -3.07296902494954 0.00109867371223797 no 3343 0.00105970242781488 4791 3668223
SGTC_879 0831-1030 162 µM -3.12117208056866 0.000934956254163031 yes 3344 0.000900663702985053 4796 1549252
SGTC_2513 baicalein 25.65 µM -3.18067771463161 0.000763828755129468 yes 3345 0.000734654941554749 4790 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2
SGTC_922 1866-0035 480 µM -3.19596785543169 0.000724781271846154 yes 3346 0.000696813185036984 4768 3156169
SGTC_1375 2910-0797 186 µM -3.24484749961832 0.000611960999241976 yes 3347 0.000587567692104343 4797 742508
SGTC_531 3788-1495 174 µM -3.31038881677119 0.000486050678406283 yes 3348 0.000465832283122615 4791 2896655
SGTC_421 streptovitacin 30 mM -3.455862947621 0.000287363296308993 yes 3349 0.000274267074629306 4791 91467 include heat shock
SGTC_3110 9122132 49.47 µM -3.5373431298763 0.00021224830883949 yes 3350 0.000202087101020215 4798 918317
SGTC_68 0986-0284 82.829 µM -3.59772904327992 0.000168882605856451 yes 3351 0.000160503887577439 4772 423278 YIL048W NEO1
SGTC_55 0767-0285 6.563 µM -3.68718170081388 0.000119624982929405 yes 3352 0.000113375726299604 4800 3116166
SGTC_990 3985-0011 41.3 µM -3.7418155375831 9.65494879311284e-05 yes 3353 9.13478001009964e-05 4802 5399565 YGL099W LSG1
SGTC_758 0868-0029 16 µM -3.82663857307969 6.88392286970401e-05 yes 3354 6.49525168256124e-05 4745 762687
SGTC_2366 9070441 60.58 µM -4.01092463964039 3.22487062234609e-05 yes 3355 3.02407073886777e-05 4799 6837235
SGTC_993 3909-8757 62.7 µM -5.44971398739621 2.85347675589061e-08 yes 3356 2.52254439023638e-08 4809 4288324 YLR208W SEC13