SGTCid condition conc unit RCK1|YGL158W.score RCK1|YGL158W.strain.pval RCK1|YGL158W.strain.significant RCK1|YGL158W.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene SGTC_2633 5,7-dihydroxyisoflavone 100 µM 5.17908081282346 4.06071404206844e-09 yes 1 1.114909325972e-07 14 5377381 SGTC_2596 sinensetin 100 µM 5.12543755891932 5.78005830766848e-09 yes 2 1.48423767805192e-07 10 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets. SGTC_1728 st035614 33.7865 µM 5.10740194044856 6.50344944967488e-09 yes 3 1.63309248994434e-07 18 15945546 SGTC_3202 9113761 49.47 µM 4.8550907618652 3.24822709569054e-08 yes 4 6.01658082254563e-07 23 4798415 SGTC_2823 7987624 58.44 µM 4.77330703067524 5.38127501004287e-08 yes 5 9.0612593845284e-07 11 2239440 SGTC_2638 epoxomicin 18 µM 4.70667573746146 8.07071900411689e-08 yes 6 1.25894466372479e-06 18 9915668 A protesome inhibitor. SGTC_978 1416-0512 87.4 µM 4.37477139108814 5.6121144708439e-07 yes 7 6.07799020269009e-06 23 6814003 SGTC_2958 9077254 16.72 µM 4.34247929952991 6.72970899985039e-07 yes 8 7.04418816952837e-06 21 16457351 SGTC_3210 9128157 49.47 µM 4.24218622791942 1.17350297769792e-06 yes 9 1.10676446490916e-05 40 17590849 SGTC_866 0495-0101 262 µM 4.06018329185436 3.12133858562151e-06 yes 10 2.45171038592714e-05 16 635694 SGTC_2946 9065502 71.43 µM 3.96377458089449 5.15724716260256e-06 yes 11 3.68869594751123e-05 7 16489101 SGTC_1345 1488-0192 31.4 µM 3.88755407126554 7.6105690316697e-06 yes 12 5.06297177443534e-05 16 658348 SGTC_763 3453-1109 128 µM 3.72551091931155 1.70103450417408e-05 yes 13 9.74600071079791e-05 23 1560353 SGTC_2753 fluvastatin 17.09 µM 3.71630216974726 1.77891714223335e-05 yes 14 0.000101079896414486 45 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5 SGTC_354 2783-3500 4.88 µM 3.70484098464284 1.88058415790238e-05 yes 15 0.000105761693517086 54 6740761 SGTC_3206 9114350 49.47 µM 3.61140764450194 2.94126260219907e-05 yes 16 0.000152269768176908 26 17087243 SGTC_769 0302-0231 76 µM 3.61014969442887 2.95881821618868e-05 yes 17 0.000153010171440434 56 571869 YER009W NTF2 SGTC_1013 4112-3890 241 µM 3.55561409783584 3.82277956430195e-05 yes 18 0.000188548623123767 47 705171 SGTC_1581 himbacine 57.9 µM 3.45298640089344 6.13206932697517e-05 yes 19 0.00027720847599239 60 5281825 An alkaloid muscarinic receptor antagonist. SGTC_2816 7982706 58.44 µM 3.36086558793685 9.27295610738335e-05 yes 20 0.000388493136280442 82 2981853 SGTC_451 chloral hydrate 100 µM 3.32999528479106 0.000106275728388632 yes 21 0.000434237273818682 88 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1 SGTC_277 nystatin 15.5 µM 3.29783583205921 0.000122350014134201 yes 22 0.000487165411653177 34 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_3059 1327-0034 3 µM 3.17830584141811 0.000204327236972251 yes 23 0.000740691988198949 82 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_385 1494-0393 12.4 µM 3.16498852122301 0.000216117118538144 yes 24 0.000775445347099818 65 3090647 SGTC_180 1486-1293 102.781 µM 3.15592683312134 0.000224499341774366 yes 25 0.000799944941484698 74 4140536 SGTC_2783 7738165 71.43 µM 3.12291022281519 0.000257675979038063 yes 26 0.000895361808329303 65 17201110 SGTC_1689 st020265 53.493 µM 3.08601905486463 0.000300124092606027 yes 27 0.00101427910930131 39 5758320 YPR016C TIF6 SGTC_918 glabranin 770.725 nM 3.05683080621519 0.000338227585849458 yes 28 0.00111845249962544 74 124049 Also referred to as licorice root. SGTC_344 k064-0035 6.43 µM 3.01442983939841 0.000401646013572538 yes 29 0.0012873137607146 62 5088750 SGTC_2819 7996655 46.38 µM 3.00355579613992 0.000419601437553629 yes 30 0.00133422306937089 53 6456960 SGTC_2342 7990637 118.86 µM 2.92126472652455 0.000581607535714164 yes 31 0.00174306734612936 96 2033102 YER133W GLC7 SGTC_1204 4049-0315 18.3 µM 2.91233501768639 0.000602296384442306 yes 32 0.00179368825614498 87 588402 SGTC_958 1222-0007 33 µM 2.88362942127573 0.000673497033498688 yes 33 0.00196560535237253 88 7312461 SGTC_1784 st039334 36.3 µM 2.85940894910606 0.000739529120117795 yes 34 0.00212215619903106 72 3496984 SGTC_1210 3013-0140 750 nM 2.78189940364444 0.000993013173013711 yes 35 0.00270208941226456 52 905973 SGTC_548 1436-0017 110 µM 2.66661922187374 0.00151962140747416 no 36 0.00383092128199132 123 9677137 SGTC_3011 9081274 71.4286 µM 2.66260334024526 0.00154188537103259 no 37 0.00387693783189498 91 6625322 SGTC_3218 9131285 49.47 µM 2.66235414527868 0.00154327665530664 no 38 0.00387980952142532 141 17156417 SGTC_1660 st012960 28.1 µM 2.66139496331806 0.00154864256871533 no 39 0.00389088080206377 117 24207266 SGTC_875 0709-0210 25.7 µM 2.64612961685665 0.00163636216069333 no 40 0.00407093062208774 106 6251364 SGTC_3038 9091290 49.47 µM 2.6297463438813 0.00173552187704944 no 41 0.0042724299134962 87 25236843 SGTC_674 0498-0004 451 µM 2.62675130492583 0.00175422984333081 no 42 0.00431021559560446 93 4231473 SGTC_1134 3477-0009 42.5 µM 2.61567653839068 0.00182501099886031 no 43 0.00445254366936355 144 3973534 SGTC_1009 4106-0057 9.87 µM 2.61392121923901 0.00183646506545754 no 44 0.00447548365762556 78 2928005 SGTC_1103 duloxetine 36.1 µM 2.60951150303143 0.00186552892320316 no 45 0.00453357987881884 126 60835 A selective serotonin reuptake inhibitor. SGTC_1218 1348-1416 30.7 µM 2.59148235836997 0.00198875642873972 no 46 0.00477817205663574 89 6787668 SGTC_1425 4048-4433 7.33 µM 2.58840462620388 0.00201051619018794 no 47 0.00482108220549088 135 23734946 SGTC_643 k048-0106 28.4 µM 2.53280322203479 0.00244270347330403 no 48 0.00565772275367375 78 6763920 SGTC_1132 3456-3614 2.5 µM 2.52722559870022 0.00249039650544972 no 49 0.00574838128525215 181 3125502 SGTC_2648 atorvastatin 78.68 µM 2.49653897791743 0.00276817377278218 no 50 0.00627059425480884 94 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11 SGTC_2717 st081029 62.2815 µM 2.43929160782515 0.00336213712081561 no 51 0.00735804385486954 85 5292846 SGTC_1878 temozolomide 1 mM 2.4293182329069 0.00347661360184229 no 52 0.00756362400279815 89 5394 DNA alkylating agent. SGTC_883 0850-0245 24.6 µM 2.40489274883791 0.00377189689751809 no 53 0.00808860635809287 140 6823229 YPR165W RHO1 SGTC_2698 st077697 67.5 µM 2.39880663879521 0.00384888764142283 no 54 0.00822429898921081 113 3154499 SGTC_1288 0973-0013 65.5 µM 2.39706587875979 0.00387116619550376 no 55 0.00826347599606149 122 4315430 SGTC_3237 9133362 49.47 µM 2.39458953705482 0.00390305797696942 no 56 0.00831949018911821 146 43845137 SGTC_2694 st077685 81.9 µM 2.3931604790202 0.00392156915418339 no 57 0.00835196659592926 151 2838096 SGTC_2752 diclazuril 33.15 µM 2.39306399449503 0.00392282178765996 no 58 0.0083541632844626 289 456389 An antifungal agent for coccidioides. YHR062C RPP1 SGTC_2198 6589944 200 µM 2.39084608062447 0.00395171538251573 no 59 0.0084047991595448 86 5290268 SGTC_2 0422-0095 29 µM 2.38948517972863 0.00396953857108261 no 60 0.00843600228121937 58 6790840 SGTC_2011 4012611 177 µM 2.38804854144785 0.00398843174612119 no 61 0.0084690522112915 151 2049887 SGTC_1277 0873-0036 22 µM 2.38057928716686 0.00408796328923692 no 62 0.00864272037632896 152 5965735 SGTC_773 4358-1457 44.6 µM 2.3781411976228 0.00412092999603485 no 63 0.00870008082840398 173 1186886 SGTC_1262 0737-0114 49.6 µM 2.37469836982015 0.00416788745144331 no 64 0.0087816479872737 160 765919 SGTC_604 1000-0114 314 µM 2.37140697116842 0.00421322649430269 no 65 0.00886025350872171 138 1572745 SGTC_1267 0828-0272 9.49 µM 2.36220519602609 0.00434233041520258 no 66 0.00908329189174817 133 745334 SGTC_1620 st003704 16.5 µM 2.35070622501887 0.00450862807819665 no 67 0.00936891056908624 103 2834414 SGTC_985 1493-0307 8.71 µM 2.34172820041205 0.0046423969737238 no 68 0.00959734384339075 97 3278274 SGTC_2982 9019404 25.97 µM 2.30478146270596 0.0052309162383601 no 69 0.0105894079035421 150 22333232 SGTC_705 1124-0212 310 µM 2.29623831494852 0.00537610418670412 no 70 0.0108311294560959 143 9554485 SGTC_2341 7987486 176.74 µM 2.27954155004379 0.00567023993160839 no 71 0.0113174464889469 172 1258686 SGTC_3223 9129970 49.47 µM 2.27653768052791 0.00572464789894601 no 72 0.0114069240046606 158 17248386 SGTC_1726 st035556 14.5795 µM 2.27119376660708 0.00582258657319571 no 73 0.0115676253062543 209 5919439 SGTC_1498 4478-3555 97.6 µM 2.26591685331235 0.00592075315441257 no 74 0.0117282372684034 70 3437919 SGTC_161 4065-0411 162.148 µM 2.2151452272882 0.00694285573291945 no 75 0.0133750489816966 235 1906281 YLR208W SEC13 SGTC_1388 3346-4487 254 µM 2.19604853186923 0.00736586563617334 no 76 0.0140442349330694 176 3345614 SGTC_1203 3992-3522 103 µM 2.18836484725783 0.00754237444783451 no 77 0.0143215183702903 190 5322312 SGTC_607 4491-0986 66.8 µM 2.17712238296553 0.00780734707269418 no 78 0.0147357187182374 182 698981 YDR232W HEM1 SGTC_1751 st044839 27.194 µM 2.17610154221107 0.00783180800961276 no 79 0.0147738343182345 123 5291326 SGTC_602 3130-1533 38.1 µM 2.15832494086999 0.00826870430061354 no 80 0.0154512884608532 200 720941 SGTC_1422 4031-0024 15.5 µM 2.13829690561144 0.00878644868163262 no 81 0.0162463267772181 151 782427 SGTC_2435 5706476 10.6 µM 2.12531463236536 0.00913704060568092 no 82 0.01678018406365 213 5725375 SGTC_2463 5473429 200 µM 2.12134469935053 0.00924666774985563 no 83 0.0169464026714639 172 5399405 SGTC_1122 capsaicin 818.572 nM 2.11972398353406 0.00929175261299112 no 84 0.0170146645931497 187 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_3004 9076122 71.4286 µM 2.11968241601843 0.00929291145826989 no 85 0.0170164184365831 186 44782551 SGTC_718 1130-0073 349 µM 2.112460327259 0.00949618300745569 no 86 0.0173234926610443 184 6740020 SGTC_968 1309-0633 340 µM 2.11180239689406 0.00951489278048106 no 87 0.0173517008177572 170 3761976 SGTC_2657 nystatin 74.44 µM 2.08309817872702 0.0103631663049213 no 88 0.0186211376839354 188 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_336 4111-0029 111 µM 2.07178810628002 0.0107150891504241 no 89 0.0191426031797149 162 3131175 SGTC_3296 9122258 64.045 µM 2.06014059323276 0.0110883437428264 no 90 0.0196925510857212 213 4730474 SGTC_1888 azatryptophan 97.5 µM 2.05864904899473 0.0111369489528939 no 91 0.0197639352114732 158 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides SGTC_2625 euphol 100 µM 2.05790840560068 0.0111611531921952 no 92 0.0197994633544033 228 6708538 A triterpene alcohol. SGTC_3128 9127691 49.47 µM 2.05534575227798 0.0112452540087419 no 93 0.0199228105780197 168 41316314 SGTC_276 colchicine 750 µM 2.04573400628316 0.0115656177021661 no 94 0.0203912740241056 211 2833 A microtubule depolymerizer. SGTC_2187 6125751 200 µM 2.04067149839152 0.0117375180590254 no 95 0.0206417450837832 200 874498 SGTC_2898 9056270 58.44 µM 2.02867920653831 0.0121535954946717 no 96 0.0212454875723809 137 19154699 SGTC_910 3454-3003 490 µM 2.02739215615617 0.0121990008812854 no 97 0.0213111617407738 230 820824 SGTC_3175 9106517 49.47 µM 2.02612755203543 0.0122437575100233 no 98 0.0213758576727882 178 41468073 SGTC_2601 securinine 100 µM 2.0232375075647 0.012346575900394 no 99 0.0215243331845905 218 442872 A GABA receptor antagonist. SGTC_2101 5377231 179.231 µM 2.02160844893674 0.0124048614925564 no 100 0.021608409260547 170 2844213 SGTC_423 5-fluorouracil 457 µM 1.98451997507892 0.0137978183061333 no 101 0.0235989517698688 229 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_2035 5154463 94.595 µM 1.9626653397254 0.0146802270528966 no 102 0.0248425365170671 259 2769623 SGTC_1276 0871-0068 94.2 µM 1.96159519029733 0.0147246551716109 no 103 0.0249048163450189 198 3414906 SGTC_1272 0839-0021 27 µM 1.95288481425354 0.0150905946797219 no 104 0.0254166227535012 237 5027250 SGTC_646 4092-0839 27.3 µM 1.9525943368348 0.0151029316607617 no 105 0.0254338413741249 224 877796 SGTC_3041 9091929 49.47 µM 1.94896113493063 0.0152579724033056 no 106 0.0256500331204087 247 25236887 SGTC_3039 9090270 49.47 µM 1.93824206035511 0.0157233812878598 no 107 0.02629684874425 182 17173750 SGTC_695 3505-6186 243 µM 1.92678139560801 0.016234408086572 no 108 0.0270034394897186 227 1819379 SGTC_1469 k284-2957 126 µM 1.91174429696325 0.0169264351688866 no 109 0.0279544998039758 207 23884841 SGTC_2640 pentamidine 10.38 µM 1.91099144509999 0.0169617355937137 no 110 0.0280028401454836 279 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_3 0833-0587 95.581 µM 1.90754142425826 0.0171243096158845 no 111 0.028225256071702 220 5382644 SGTC_1246 0422-0085 105 µM 1.90642007583249 0.0171774364361153 no 112 0.0282978630477558 290 264295 SGTC_1579 chlormadinone acetate 49.4 µM 1.90533759071063 0.0172288555407521 no 113 0.0283681010317547 241 45114258 A steroidal progestin. SGTC_260 nsc-65238 3.989 µM 1.90394495869094 0.0172952002935961 no 114 0.0284586764868668 214 3246252 SGTC_3136 9095672 49.47 µM 1.90284262802731 0.0173478697616688 no 115 0.0285305415067548 214 17217380 SGTC_318 1488-0629 67.2 µM 1.89872855225718 0.0175456521135275 no 116 0.0288000877237788 215 3662576 SGTC_844 0330-0132 15.3 µM 1.89202936809328 0.0178718311859616 no 117 0.0292435339938491 240 2828079 SGTC_2879 9041815 71.43 µM 1.88867585855078 0.018037044753347 no 118 0.0294676376896429 131 4942971 SGTC_102 gallobenzophenone 83.616 µM 1.8866920808173 0.0181353889094294 no 119 0.0296008767224797 280 70837 SGTC_1026 k007-1105 30.6 µM 1.88335974839075 0.0183016152246033 no 120 0.0298258156798894 356 7066794 SGTC_2225 6654152 15.4 µM 1.86696418329918 0.0191385010456226 no 121 0.0309532948608562 188 97582 YGR029W | YLR033W ERV1 | RSC58 SGTC_1702 st027038 51 µM 1.86505735293054 0.0192379118758641 no 122 0.0310866827574462 276 5521182 SGTC_686 1319-0111 510 µM 1.86460837654773 0.0192613825736473 no 123 0.0311181589342492 264 4562600 SGTC_1684 st024538 14.6195 µM 1.84397099020902 0.0203668011639447 no 124 0.0325936840299538 269 6732859 SGTC_2331 7980721 200 µM 1.83543965772124 0.0208392362247337 no 125 0.033220286110486 291 2981221 SGTC_1430 4049-0248 69.1 µM 1.83503470646051 0.0208618897449576 no 126 0.0332502736048944 299 22774488 SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM 1.8349515928364 0.0208665418108198 no 127 0.033256431100729 252 2374 Ca(2+)-ATPase inhibitor. SGTC_1094 duloxetine 25.4 µM 1.8314631861513 0.0210625896325694 no 128 0.0335157188305495 276 60834 A selective serotonin reuptake inhibitor. SGTC_185 k048-0037 25.491 µM 1.83015821338276 0.0211363283517394 no 129 0.0336131421086535 239 6827589 SGTC_107 0358-0022 2.6945 µM 1.8163136349602 0.0219321677179125 no 130 0.034661137425323 173 521106 YGL093W | YPR107C SPC105 | YTH1 SGTC_2307 7538926 6.34 µM 1.80696687929145 0.0224836428529609 no 131 0.0353837217587844 335 96582 SGTC_935 2996-0153 430 µM 1.80618133221123 0.0225305195688406 no 132 0.03544500993361 265 23738523 SGTC_1514 1189-1591 158 µM 1.80613532729071 0.0225332674177433 no 133 0.0354486019218256 348 767698 YMR146C TIF34 SGTC_3068 9116768 49.47 µM 1.80525019928793 0.022586190675542 no 134 0.0355177693896093 269 41904888 SGTC_2125 5246583 200 µM 1.80519789552138 0.0225893212800971 no 135 0.0355218600765942 351 835267 SGTC_51 1013-0126 23.419 µM 1.80461920301292 0.0226239829277217 no 136 0.0355671455056218 267 1627850 SGTC_1591 genipin 88.4 µM 1.80364139696671 0.0226826519527291 no 137 0.0356437709980389 233 442424 A DNA cross-linking agent. SGTC_863 0466-0191 129 µM 1.77597344587636 0.0243966728314651 no 138 0.0378686469978981 346 765160 YPR165W RHO1 SGTC_46 0329-0187a 2.197 µM 1.76972884989032 0.0247982116123347 no 139 0.0383861607396595 410 46494817 SGTC_713 1488-1073 324 µM 1.76966182365906 0.0248025514086548 no 140 0.0383917465791277 250 3312542 SGTC_1075 aripiprazole 15.2 µM 1.76708692130449 0.0249697534292063 no 141 0.0386068362436817 357 60795 An atypical antipschotic. YIL048W NEO1 SGTC_1606 st000094 49.2 µM 1.76050129385782 0.0254016972024849 no 142 0.0391614241619876 293 1242210 SGTC_1884 5633444 25 µM 1.75371890930569 0.0258530704550549 no 143 0.0397393418996604 352 5724239 SGTC_3103 9120822 49.47 µM 1.75181758314593 0.0259808031038794 no 144 0.0399025898833365 299 17141819 SGTC_922 1866-0035 480 µM 1.74558285383929 0.0264033667918516 no 145 0.0404417318983683 397 3156169 SGTC_1405 3909-7894 12 µM 1.73905601626952 0.0268518667774554 no 146 0.0410124551309431 292 7104060 SGTC_3215 9129942 49.47 µM 1.73790374847286 0.0269317032273982 no 147 0.0411138875449253 249 17682944 SGTC_3100 9120536 49.47 µM 1.73781052289753 0.0269381711441151 no 148 0.0411221029400885 197 16421196 SGTC_632 0781-2353 4.65 µM 1.73441153787459 0.0271748770085698 no 149 0.041422544670018 341 6811515 YHR007C ERG11 SGTC_3238 9133470 49.47 µM 1.71335176507532 0.0286804690567646 no 150 0.0433239222157544 264 3534688 SGTC_1221 2958-7315 257 µM 1.70924333965858 0.0289821285115999 no 151 0.0437029419566671 317 4562705 SGTC_1216 1165-0504 9.65 µM 1.7079609417393 0.0290768262975835 no 152 0.0438217950165804 337 6304004 SGTC_1976 st070609 63.5 µM 1.70781013180466 0.029087979628536 no 153 0.0438357892493289 322 682556 SGTC_1410 3909-8106 77.9 µM 1.70667133002891 0.0291723159053069 no 154 0.0439415794642236 273 1039210 SGTC_2275 7947463 200 µM 1.70287269405672 0.0294551016903598 no 155 0.044295947539265 294 1225414 SGTC_1037 k284-1091 78.7 µM 1.70064177149067 0.0296222387478163 no 156 0.044505137659774 270 3334711 SGTC_1520 flindersine 88 µM 1.6988528308532 0.0297568311973493 no 157 0.0446734582061809 335 68230 Flindersine is a natural alkaloid of the quinoline subtype. SGTC_2273 7815444 169.05 µM 1.69856220894972 0.0297787442153656 no 158 0.0447008510272951 317 2824616 SGTC_2531 methyl deoxycholate 70.07 µM 1.69437553172807 0.0300959098424685 no 159 0.0450969730083604 310 16667744 Haematoxylin. SGTC_1697 st025554 27.742 µM 1.69425385777003 0.0301051690848294 no 160 0.0451085272812738 293 1269519 SGTC_1404 3909-7820 48.3 µM 1.69081159859135 0.0303681010018614 no 161 0.0454363956268019 297 23741373 SGTC_1047 2043-3044 82 µM 1.68793085180565 0.0305896025527997 no 162 0.0457122517341846 352 669592 SGTC_1876 myriocin 605 nM 1.6847320303757 0.0308371270954601 no 163 0.0460201418972874 310 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1 SGTC_592 k241-0073 46.5 µM 1.68243329533169 0.0310160249790483 no 164 0.0462424247871037 339 4230158 SGTC_1020 4335-0961 93.3 µM 1.67484766261124 0.0316124757125195 no 165 0.046982062287602 323 669075 SGTC_2826 7992541 19.48 µM 1.67458333185348 0.0316334295108579 no 166 0.0470080059320143 333 2985066 SGTC_701 4424-0219 185 µM 1.67450721119841 0.0316394658094909 no 167 0.0470154791835393 346 2911779 SGTC_268 camptothecin 39.6153 µM 1.67041705825366 0.0319652136239587 no 168 0.0474184384844657 460 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_1968 st069590 43.6 µM 1.66882693240701 0.0320925998078912 no 169 0.0475758417830409 309 6384066 SGTC_1575 cyproterone acetate 48 µM 1.66552883666858 0.0323581491203333 no 170 0.0479036477128606 341 9880 An androgen receptor antagonist and liver toxin. SGTC_3061 glucosamine 200 µM 1.66300093969191 0.0325629103498729 no 171 0.0481561236966633 297 91431 and experimental redox chemotherapeutic SGTC_3171 9103192 49.47 µM 1.65845421458101 0.0329338873685716 no 172 0.0486129108045614 274 13018434 SGTC_1983 st071813 46.9 µM 1.65165760112152 0.0334949269568255 no 173 0.0493021852608333 340 11838595 SGTC_717 1532-0246 73.2 µM 1.65033703291019 0.0336048435807914 no 174 0.0494370109709125 368 9561992 SGTC_2220 6782180 200 µM 1.64613017926414 0.0339569790995264 no 175 0.0498684801227064 243 833803 SGTC_874 0599-0792 117 µM 1.64553214993412 0.0340072827564259 no 176 0.049930059139786 407 765305 SGTC_228 caffeine 993.056 µM 1.64533506169779 0.0340238743919642 no 177 0.0499503665757499 287 2519 Caffeine is a phosphodiesterase inhibitor. SGTC_1885 st057546 99.9 µM 1.63837421852462 0.0346141472365199 no 178 0.0506718269476609 378 702008 SGTC_2200 6600604 21.907 µM 1.63419236530075 0.0349727910920066 no 179 0.0511092325715187 394 2904777 SGTC_3144 9087057 49.47 µM 1.62576246514979 0.0357050278448348 no 180 0.0520000980090235 365 17249618 SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM 1.62111375011892 0.036114169149716 no 181 0.0524966228020273 391 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis. SGTC_453 enantio-paf c16 10 µM 1.61021783699734 0.0370881939407626 no 182 0.0536751543710441 568 13871343 A lipid and platelet activating factor SGTC_2496 diffractaic acid 79.83 µM 1.60887622068306 0.0372095967309983 no 183 0.0538217050262199 388 94870 An apoptosis inducer which activates caspases. SGTC_210 3551-0445 56.827 µM 1.60519774532393 0.03754412821093 no 184 0.0542251467568348 387 2865180 YOR207C RET1 SGTC_2446 5162541 200 µM 1.60257732784625 0.0377839314480623 no 185 0.0545140012935897 349 1549321 SGTC_31 0508-1974 57.237 µM 1.59517409199059 0.0384681881462474 no 186 0.0553366553062969 356 6810525 SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM 1.59171263984152 0.0387915663148274 no 187 0.0557246434692188 446 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_1734 st037168 69.4 µM 1.59092199393572 0.0388657403828058 no 188 0.0558135660683687 382 708907 SGTC_3182 9108849 49.47 µM 1.57758571528444 0.0401343744377557 no 189 0.0573304080921756 426 17133045 SGTC_307 1501-1223 22.3 µM 1.57259633518527 0.0406175605754404 no 190 0.0579061584075018 359 2830329 SGTC_3062 9077494 49.47 µM 1.57184817755455 0.040690419756651 no 191 0.0579928826780257 368 16459633 SGTC_1031 k035-0009 16 µM 1.57183275516686 0.0406919227777807 no 192 0.0579946714698622 420 5180959 SGTC_1289 0976-0073 69.1 µM 1.56297245184602 0.04156289927258 no 193 0.0590295372838664 393 3391136 SGTC_2621 lithochol-11-enic acid 100 µM 1.56120546099029 0.0417383898296218 no 194 0.0592376404603592 435 6708711 SGTC_788 1182-0090 188 µM 1.55440527307671 0.0424193640394903 no 195 0.060043888115841 520 5715185 SGTC_343 4130-2827 29.8 µM 1.55317200944386 0.0425438210879863 no 196 0.0601910232258018 414 1118244 SGTC_790 1575-0012 79.1 µM 1.55197541250272 0.0426648599319039 no 197 0.0603340534422256 404 378741 YLR208W SEC13 SGTC_152 4469-0003 551.229 µM 1.54543280071454 0.0433315929538533 no 198 0.0611208057560215 373 697280 SGTC_1893 st059353 36.1 µM 1.54446869597723 0.04343054864854 no 199 0.0612374145919022 429 3112488 SGTC_1494 4358-1428 177 µM 1.54193984617063 0.0436909767861653 no 200 0.0615441059765464 415 1564571 SGTC_2285 7945142 200 µM 1.54186033742474 0.043699185209653 no 201 0.0615537679753993 393 2970608 SGTC_389 tpck 16.7 µM 1.5417356834763 0.0437120568947643 no 202 0.0615689184582215 381 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.  SGTC_1320 1313-0481 95.3 µM 1.5406620585001 0.0438230453871802 no 203 0.0616995277789475 395 6813365 YLR208W SEC13 SGTC_1413 3910-0535 34.4 µM 1.53439808704276 0.0444751380575053 no 204 0.0624658739709893 390 2876951 SGTC_1685 st024049 53.0905 µM 1.52506479368692 0.045461232536906 no 205 0.0636214687008555 363 1941139 SGTC_2384 9036245 200 µM 1.51960016891865 0.0460467017871868 no 206 0.0643057477162217 424 6462766 SGTC_2038 4100038 30.985 µM 1.51944169260745 0.0460637705810853 no 207 0.0643256770890422 432 3596803 SGTC_2358 9037157 4 µM 1.51690542222639 0.0463376334023135 no 208 0.0646452822200791 407 2388925 SGTC_1619 st003326 88.7 µM 1.51633155684202 0.0463997795543921 no 209 0.0647177680077166 371 2849032 SGTC_822 1487-0950 154 µM 1.51604702589831 0.0464306173377614 no 210 0.064753730931054 398 1958375 SGTC_1373 2887-0003 58.5 µM 1.51453965800514 0.0465942621125359 no 211 0.0649445116929182 406 776948 SGTC_2353 9059630 146.67 µM 1.51360618925452 0.0466958343721515 no 212 0.0650628752158464 374 4779114 SGTC_3300 9124615 50.48 µM 1.5108615064297 0.0469955172118808 no 213 0.0654118700311378 415 24824903 SGTC_1571 st070080 73.4 µM 1.50983220010483 0.0471083006237592 no 214 0.065543123206984 409 4315245 SGTC_2891 9063876 19.48 µM 1.5080042794413 0.0473091247768322 no 215 0.0657767158759882 314 6472478 SGTC_2219 9098279 200 µM 1.50728802298828 0.0473880030079267 no 216 0.0658684231144804 402 902349 SGTC_1746 st038117 42 µM 1.5010441906036 0.0480800809989458 no 217 0.0666720660948156 439 2898218 SGTC_1669 st015249 58.4 µM 1.49731584798716 0.0484971793759124 no 218 0.0671555465543018 383 722793 SGTC_474 dl-dihydrosphingosine 5 µM 1.49724277724814 0.0485053827872649 no 219 0.0671650491671424 430 3058739 A sphingolipid protein kinase C inhibitor. SGTC_1207 2099-0101 141 µM 1.49460466832897 0.0488022984979164 no 220 0.0675088235417781 466 5837381 SGTC_259 usnic acid 108.925 µM 1.4925434899135 0.0490352907499784 no 221 0.0677783625342359 428 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_734 2023-0417 80 µM 1.49071341799507 0.0492429030525299 no 222 0.0680183758634429 439 3935732 SGTC_587 k089-0003 57 µM 1.47983336710046 0.0504917191156679 no 223 0.0694588607867781 276 9659696 SGTC_2593 nobiletin 86.24 µM 1.47800168801468 0.0507044201115093 no 224 0.0697036632136967 389 72344 An anti-infammatory. SGTC_909 3448-9333 149 µM 1.47705598787414 0.0508145171143473 no 225 0.069830314979664 391 3344074 SGTC_1301 naphtanilide LB 4.81 µM 1.47329138388036 0.0512546749110806 no 226 0.0703362414854872 455 67238 An a1-adrenergic receptor antagonist or alpha blocker. SGTC_2587 piperic acid 92.2 µM 1.47085613979162 0.0515410159128367 no 227 0.0706650131389253 409 5370536 SGTC_232 clozapine 119 µM 1.47024956075193 0.0516125362380863 no 228 0.0707470881569333 428 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_378 3970-0959 8.33 µM 1.46375277283113 0.0523835154105188 no 229 0.0716307552931408 436 6615653 SGTC_1724 st037281 8.293 µM 1.46048532231463 0.0527747074354865 no 230 0.0720783692777683 476 574124 YDL195W SEC31 SGTC_1647 st011722 22.4 µM 1.45850029491869 0.0530134921823888 no 231 0.0723513469534131 413 2854783 SGTC_2340 7987427 183.45 µM 1.45687424231878 0.0532097325106963 no 232 0.0725755486646014 439 2239331 SGTC_571 k831-0106 44.2 µM 1.45577039932833 0.053343277758181 no 233 0.0727280505822267 409 4783639 SGTC_3234 9132280 49.47 µM 1.45181820402449 0.0538236020269923 no 234 0.0732760804191148 471 17612295 SGTC_2617 dihydrotanshinone i 20.83 µM 1.44557357484532 0.0545895074911961 no 235 0.074148421420348 480 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12 SGTC_1557 sumaresinolic acid 42.3 µM 1.44355992204014 0.0548383119088706 no 236 0.0744314027076353 439 9982268 A natural terpine and antifungal of unknown mechanisn. SGTC_778 3456-2434 196 µM 1.44218761161252 0.0550083858195916 no 237 0.0746247272300427 552 5539063 SGTC_842 0271-0008 11.1 µM 1.43835262424481 0.0554858758425242 no 238 0.0751670137729663 491 1221709 SGTC_2067 5224629 34.075 µM 1.43734104343364 0.0556123705060162 no 239 0.0753105560060841 468 2835000 SGTC_1380 2291-0730 164 µM 1.43681044382385 0.0556788110903841 no 240 0.0753859310199584 426 2999191 SGTC_539 4859-0462 2.54 µM 1.43494471069568 0.0559129318573009 no 241 0.0756514267520056 443 46499474 YNL221C | YBR257W POP1 | POP4 SGTC_2369 9071472 200 µM 1.42780008514894 0.0568166605398011 no 242 0.0766747041679579 474 17296037 SGTC_3027 9089541 49.47 µM 1.42481772944585 0.0571972876005458 no 243 0.0771049479883778 479 9943819 SGTC_3186 9110464 49.47 µM 1.41410916837853 0.058580543207039 no 244 0.0786649257968039 460 17018021 SGTC_69 0096-0274 206.684 µM 1.41230506187283 0.0588161486730793 no 245 0.0789300783053569 544 6741392 SGTC_2525 harmine 47.85 µM 1.41079213335075 0.0590143007800164 no 246 0.0791529573692337 404 5280953 A monoamine oxidase inhibitor SGTC_3003 9075612 71.4286 µM 1.40875235443485 0.0592822843937652 no 247 0.0794542040463922 469 6501993 SGTC_3299 9121982 43.1275 µM 1.40492128990406 0.0597881830007828 no 248 0.0800223424926527 483 17594604 YPL160W CDC60 SGTC_1400 3771-8998 51.5 µM 1.40477673221587 0.0598073381018005 no 249 0.0800438400593066 430 670767 SGTC_841 0251-0215 91.2 µM 1.4040407880526 0.0599049313996259 no 250 0.0801533520181733 557 3888614 SGTC_414 piperonyl butoxide 100 µM 1.3986392695565 0.0606250469573357 no 251 0.0809605920782523 451 5794 A potent inhibitor of cytochrome P450. SGTC_852 0418-0143 439 µM 1.39460626082007 0.0611671184087259 no 252 0.0815673030371964 569 5369229 SGTC_2196 6573537 42.6665 µM 1.39428860642525 0.0612099743267932 no 253 0.0816152350511647 443 2903087 SGTC_2370 9071495 200 µM 1.39408932957239 0.0612368714714946 no 254 0.0816453154905853 468 21791103 SGTC_1511 0906-3109 28.5 µM 1.38997450868637 0.06179433099027 no 255 0.0822683091127904 597 2882180 SGTC_752 1896-0090 130 µM 1.38865574206932 0.0619738280336414 no 256 0.0824687291746251 491 772567 SGTC_245 methotrexate 289.6 µM 1.38811043942484 0.0620481678583074 no 257 0.082551709092603 528 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2 SGTC_1895 st058434 18.3 µM 1.38721164733938 0.0621708498964344 no 258 0.0826886174320651 491 5393175 SGTC_547 1120-0019 610 nM 1.38030304498994 0.0631201773844785 no 259 0.0837466789126002 495 3676939 SGTC_234 nsc-17383 10.7 µM 1.37443886745095 0.0639348133078362 no 260 0.0846527383390129 534 408974 SGTC_2977 9011197 71.43 µM 1.37437850935813 0.0639432404026916 no 261 0.0846621021923035 419 2704722 SGTC_588 3970-1144 52.9 µM 1.37257687666812 0.0641951792107693 no 262 0.0849419622495974 533 1888707 SGTC_1705 st027868 56.3335 µM 1.37195542796479 0.0642822608283891 no 263 0.0850386568589946 471 292948 SGTC_2269 7935389 174.42 µM 1.37043745617153 0.0644953553535395 no 264 0.0852751932540041 499 97605 SGTC_1483 3453-0561 55.9 µM 1.36872567935209 0.0647363143602128 no 265 0.0855425200657861 553 4546991 SGTC_1607 st000305 50.6 µM 1.36801462802595 0.0648366110799081 no 266 0.0856537486790541 510 5457690 SGTC_594 1487-1584 10.8 µM 1.361708126531 0.0657314570035652 no 267 0.0866450077963199 514 5013332 SGTC_2862 9027634 71.43 µM 1.34809904601455 0.0676950797078733 no 268 0.088813264120227 491 5012562 SGTC_639 0833-0042 114 µM 1.34746346058658 0.0677878826490114 no 269 0.08891550696709 550 5978911 YPR085C | YHR062C ASA1 | RPP1 SGTC_1001 4048-4355 44.4 µM 1.34451378363306 0.0682198568889254 no 270 0.0893911511271092 503 21824233 SGTC_1 0258-0098 57.368 µM 1.34269959816516 0.068486593991157 no 271 0.0896846324423205 447 6790032 YDR047W HEM12 SGTC_1137 ixabepilone 100 µM 1.33826376702055 0.0691421761958603 no 272 0.0904052343404509 581 154225 A novel microtubule stabilizer. SGTC_911 3456-4043 236 µM 1.33822728171219 0.069147588427836 no 273 0.0904111791624836 537 914281 SGTC_1816 st051957 91.6 µM 1.33667362675019 0.0693783607179754 no 274 0.0906645971275532 494 674121 SGTC_1561 5-methoxyflavone 52.9 µM 1.33618285012404 0.0694513814290589 no 275 0.0907447575850131 437 94525 SGTC_2493 resveratrol 26.09 µM 1.33572087741988 0.0695201705847072 no 276 0.0908202614306112 476 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase. SGTC_2810 7959871 45.46 µM 1.33334524242738 0.0698747388208568 no 277 0.0912092665299713 584 2974535 SGTC_2130 NSC 7 2.4545 µM 1.33085100776067 0.0702485042037828 no 278 0.0916190202000409 565 21448 SGTC_1390 3413-2614 145 µM 1.33010607470843 0.0703604313744396 no 279 0.0917416621656413 549 3421432 SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM 1.32937879891852 0.070469837755019 no 280 0.0918615144197649 510 4330530 SGTC_3150 9097574 49.47 µM 1.32743549661879 0.0707628164253153 no 281 0.0921823320505474 488 17217476 SGTC_959 1222-0044 107 µM 1.32616323175355 0.0709551336374942 no 282 0.0923928176398254 522 6083612 SGTC_398 bronopol 33.3 µM 1.32513969520367 0.0711101439616349 no 283 0.0925624111935076 528 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them. SGTC_3253 9135987 49.47 µM 1.32491167977843 0.071144711334424 no 284 0.0926002232578195 471 4182430 SGTC_3250 9135583 49.47 µM 1.32381263345987 0.0713115088911276 no 285 0.0927826396683147 495 7699353 SGTC_230 MPP+ 141.667 µM 1.32326683481104 0.0713944538918685 no 286 0.0928733283802938 515 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death. SGTC_2664 lyso-paf C-16 73.48 µM 1.32053895418683 0.0718101200994365 no 287 0.0933275695763646 556 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_319 1348-1596 45.5 µM 1.31874752754592 0.0720841003318768 no 288 0.0936267659158993 557 5380505 SGTC_1306 1185-0270 9.02 µM 1.31815183393088 0.0721753828456233 no 289 0.093726412838445 594 1548076 SGTC_2440 5628896 157.78 µM 1.31743755869455 0.0722849532737605 no 290 0.0938459991549839 512 5522048 SGTC_1333 1482-0047 286 µM 1.31707497448856 0.0723406227541788 no 291 0.0939067472773736 575 3811116 SGTC_500 h-89 112 µM 1.31549536012575 0.0725835327230114 no 292 0.0941717378483632 576 449241 Protein kinase A inhibitor; also known to inhibit several other kinases. SGTC_1993 st073995 70.8 µM 1.3129482416506 0.0729765387784712 no 293 0.0946001947622133 540 3098394 SGTC_941 3237-0776 460 µM 1.31287878246457 0.0729872787083463 no 294 0.0946118987526948 514 760008 SGTC_2139 5578692 56.4705 µM 1.3074282377485 0.073833831550865 no 295 0.0955336561609643 474 650991 YMR113W FOL3 SGTC_3153 9100258 49.47 µM 1.30512916280931 0.0741931551003696 no 296 0.0959244349807462 506 25236848 SGTC_2455 5377712 9.75 µM 1.30435337629803 0.0743147040603567 no 297 0.0960565620310761 492 2243908 SGTC_2295 7971645 200 µM 1.30246538916143 0.0746111460685497 no 298 0.0963786710623079 540 2978226 YKL099C UTP11 SGTC_2933 9026794 32.47 µM 1.30226101193888 0.0746432903874509 no 299 0.0964135873679816 562 17586027 SGTC_33 0986-0033 35.816 µM 1.30222647151069 0.0746487239277853 no 300 0.0964194892574877 502 2848082 SGTC_2490 carminic acid 95.39 µM 1.300830644871 0.0748685534999523 no 301 0.0966582149878467 462 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_2712 st079126 47.7 µM 1.30022117843369 0.0749646934877205 no 302 0.0967625869977923 497 3152970 SGTC_251 melphalan 456.522 µM 1.29780757697159 0.0753463509190145 no 303 0.0971767326589682 613 460612 A DNA alkylator. SGTC_3178 9107506 49.47 µM 1.29566338068685 0.0756866486623099 no 304 0.0975457413567711 555 8897194 SGTC_1414 3917-0015 5.4 µM 1.29192615994787 0.0762825665946206 no 305 0.0981913586490158 503 6618702 SGTC_1399 3562-5772 25 µM 1.29184018895204 0.0762963169790126 no 306 0.0982062471680368 452 23847490 SGTC_1942 st076330 65.2 µM 1.28809449862782 0.0768972437375757 no 307 0.0988565350707973 552 24208414 SGTC_25 0118-0223 35.662 µM 1.28656335761171 0.0771439204234094 no 308 0.0991232611323482 536 5333628 SGTC_957 1187-1561 14.1 µM 1.28623807627608 0.0771964026964795 no 309 0.0991799931379038 571 1538454 SGTC_2393 9031399 185.94 µM 1.28608393416303 0.0772212821115806 no 310 0.0992068852063734 546 1526623 YDL150W RPC53 SGTC_1346 1488-2224 62.4 µM 1.28480721493397 0.0774275861159477 no 311 0.0994298302528612 573 3722427 SGTC_1558 st069300 45.6 µM 1.28465442763068 0.077452302908167 no 312 0.099456535006953 460 24208000 SGTC_1948 st076329 66.6 µM 1.28208722886281 0.0778685019301157 no 313 0.0999060242456083 507 24208413 SGTC_2677 mitomycin C 100 µM 1.28070680333143 0.0780929996507569 no 314 0.100148334621166 499 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_845 0330-0138 4.51 µM 1.28007517325195 0.0781958848289285 no 315 0.10025934956723 559 9039800 SGTC_537 1334-0398 209 µM 1.27977466461497 0.0782448702610311 no 316 0.100312198317523 581 5846986 SGTC_2799 7812892 81.82 µM 1.27403794224711 0.0791844727406266 no 317 0.101324984884096 602 20205235 SGTC_1502 4534-4282 27.7 µM 1.2740065216673 0.0791896424548061 no 318 0.101330552451514 525 3278949 SGTC_1323 1348-1351 11.2 µM 1.27267031819975 0.0794097282698932 no 319 0.10156752724663 538 6989654 SGTC_2333 9017922 200 µM 1.27263221866837 0.0794160104178301 no 320 0.101574290085976 572 3163164 SGTC_523 1934-0222 13.7 µM 1.26497423440724 0.0806863696874597 no 321 0.102940282135676 578 1361595 SGTC_1066 ketoconazole 628 nM 1.26109347688172 0.0813359670287049 no 322 0.103637585272098 611 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W SGTC_624 k048-0052 28 µM 1.25889702141595 0.0817053743282973 no 323 0.104033764917777 556 6835531 SGTC_1796 st049173 110.4 µM 1.25715163819701 0.081999819510401 no 324 0.104349365790357 517 94134 SGTC_2005 4024620 188 µM 1.25572010250564 0.0822419150023787 no 325 0.104608734081486 567 236743 SGTC_3021 9087658 49.47 µM 1.25479713426553 0.0823982888199967 no 326 0.10477620659045 523 25237042 SGTC_658 3253-0951 102 µM 1.25386115179877 0.0825570960951897 no 327 0.104946238722695 694 1184878 SGTC_651 3253-0966 34.4 µM 1.24982649358576 0.0832442906473606 no 328 0.105681467891411 605 781462 SGTC_1977 st070720 65.3 µM 1.24413380203583 0.0842211888737697 no 329 0.106725161157167 529 682188 SGTC_413 propylparaben 100 µM 1.24279781184107 0.0844516940972121 no 330 0.106971174534958 570 7175 A pharmaceutical preservative. SGTC_2389 9091542 195.52 µM 1.24133404180841 0.0847047888688836 no 331 0.107241187029128 614 3626624 YOL127W RPL25 SGTC_1693 xanthone 101.9 µM 1.23738162984267 0.0853910261916887 no 332 0.107972717729647 623 7020 An insecticide. SGTC_1393 3470-5649 58.2 µM 1.23685228567542 0.085483248861452 no 333 0.108070963392858 483 4108395 SGTC_2586 curcumin 80 µM 1.23421688945191 0.0859434996278313 no 334 0.108561047772565 688 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40 SGTC_894 0960-0238 55.9 µM 1.23132589269299 0.0864505191009157 no 335 0.10910050074785 600 6741907 YDL195W SEC31 SGTC_1344 1488-0097 29.1 µM 1.23006099075413 0.0866730580454588 no 336 0.109337133224677 584 747966 SGTC_106 0092-0003 11.579 µM 1.22989690120654 0.086701958279628 no 337 0.109367857395384 505 1072148 SGTC_3271 9137798 49.47 µM 1.22528632948966 0.0875169410074709 no 338 0.110233678641316 517 6498326 SGTC_2820 7989630 71.43 µM 1.22350243724611 0.0878337980832528 no 339 0.110569992100626 486 2984098 SGTC_1247 0448-0043 5.84 µM 1.22256456259747 0.0880007273048317 no 340 0.110747102332422 646 3089013 YGL099W LSG1 SGTC_1825 st052143 62.6 µM 1.21999060973292 0.0884600720745754 no 341 0.111234217318907 559 674173 SGTC_1499 4480-0877 67.3 µM 1.21932777023719 0.0885786504176868 no 342 0.111359906253176 558 2861909 SGTC_2126 5251174 33.877 µM 1.21920176192864 0.0886012059994737 no 343 0.111383811692692 695 790722 SGTC_188 3229-0966 278.469 µM 1.21727409481915 0.0889467933773927 no 344 0.111749973567271 703 5722370 SGTC_2278 7948257 134.34 µM 1.21686684604019 0.0890199321489619 no 345 0.11182744083183 604 1247028 SGTC_2781 5567276 71.43 µM 1.21661170651487 0.0890657760617215 no 346 0.11187599328822 577 2853274 SGTC_2336 9001819 198.65 µM 1.21472461746103 0.0894053972394765 no 347 0.112235570070556 640 2989602 SGTC_2462 5162487 171.77 µM 1.21431001802079 0.0894801419873987 no 348 0.112314680772542 615 2259986 SGTC_1072 oxiconazole 14.9 nM 1.21424520276481 0.0894918312001665 no 349 0.112327051925855 636 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_162 k030-0015 37.8 µM 1.21183209561577 0.0899278355658356 no 350 0.112788329819945 623 1809920 YMR134W ERG29 SGTC_496 calpeptin 138 µM 1.21160904732429 0.0899682158802798 no 351 0.112831034836534 524 73364 A calpain inhibitor. SGTC_1349 flufenamic acid 69 µM 1.20771332935976 0.0906756649260557 no 352 0.113578774546114 579 3371 A non-steroidal anti-inflammatory. SGTC_2916 7875993 68.79 µM 1.20637946536892 0.090918836457827 no 353 0.113835605027913 620 1299250 SGTC_1837 st055472 66.5 µM 1.20422460266728 0.0913127026603352 no 354 0.11425138963168 608 676091 SGTC_3327 9140648 26.9345 µM 1.20347432446153 0.0914501351226356 no 355 0.114396410665194 589 8029710 SGTC_482 fipronil 114 µM 1.19983310774786 0.0921192942737456 no 356 0.115102081615027 551 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels. SGTC_371 0195-0006 7.36 µM 1.19799158350018 0.0924590947392881 no 357 0.115460146790958 538 3928593 SGTC_2760 etidronate 98.04 µM 1.19522149600622 0.0929719803380762 no 358 0.116000251045199 608 3305 A chelator and antioxidant. SGTC_2057 5236571 38.335 µM 1.19479783978899 0.0930506059514427 no 359 0.116083012276831 654 54684039 YBR257W POP4 SGTC_1437 4092-1038 11.6 µM 1.19202754859316 0.0935659511907758 no 360 0.116625221740778 663 3977136 SGTC_1255 0566-0045 221 µM 1.19133009851218 0.0936960262957054 no 361 0.116762011235424 637 2788469 SGTC_847 0342-0274 5.54 µM 1.19087345082815 0.0937812638172511 no 362 0.116851634229116 637 18097 SGTC_2997 9067075 71.4286 µM 1.18769896652222 0.0943753933563838 no 363 0.117476015549776 668 27209819 SGTC_499 genistein 192 µM 1.18342557358813 0.0951795692347465 no 364 0.118320263487173 589 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger. SGTC_1972 st070201 17.4 µM 1.18257959308132 0.0953393641917315 no 365 0.118487902048376 644 2829099 SGTC_1808 st050063 61.5 µM 1.18191440886867 0.0954651476635514 no 366 0.11861983205146 613 4011993 SGTC_2605 digitonin 300 nM 1.18143659536253 0.0955555754937133 no 367 0.118714663726303 733 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_3127 9126946 49.47 µM 1.17929764596558 0.0959611517005287 no 368 0.119139837652556 555 27243249 SGTC_1833 st055984 71 µM 1.17870744816765 0.096073284396083 no 369 0.11925734439341 634 676288 SGTC_1799 st045822 46.1415 µM 1.17840932329361 0.0961299622635552 no 370 0.119316731311806 623 3674992 SGTC_460 trequinsin 123 µM 1.17609191516045 0.0965713736261862 no 371 0.119779074154244 688 5537 A vasodilator. SGTC_2144 5628481 200 µM 1.17148590662243 0.0974531265865456 no 372 0.120701759738594 598 2818399 SGTC_3030 9087619 49.47 µM 1.17147499830729 0.0974552218098915 no 373 0.120703950838367 601 25236973 SGTC_706 4262-0057 46.9 µM 1.17065042901667 0.0976136972775323 no 374 0.120869659088983 624 883298 SGTC_205 1486-1330 71.903 µM 1.16810867314197 0.0981033908747241 no 375 0.121381466144283 588 4118834 SGTC_3183 9108214 49.47 µM 1.16686611101769 0.0983434363310232 no 376 0.121632221764687 523 4974831 SGTC_1650 st011916 45.8 µM 1.16565583591745 0.0985776576496908 no 377 0.121876811468399 624 242528 SGTC_327 1273-0057 3.96 µM 1.16355948059307 0.0989843255415281 no 378 0.122301290067143 615 3108138 SGTC_926 2268-1401 59.4 µM 1.16206756165581 0.0992744865738668 no 379 0.122604011283724 656 2931578 SGTC_746 1095-0025 46.6 µM 1.16203990547355 0.0992798712473139 no 380 0.12260962788272 703 6749286 SGTC_1105 epirubicin 18.1 µM 1.1615418346852 0.0993768824517607 no 381 0.122710810266636 637 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_860 0443-0016 25.1 µM 1.15810173816797 0.100048816335249 no 382 0.123411260386088 658 5337942 SGTC_65 0798-0905 34.986 µM 1.15755188147695 0.100156523390439 no 383 0.123523477744738 753 3602145 SGTC_472 calcifediol 10 µM 1.15700628334007 0.100263479914854 no 384 0.123634896617266 583 5283731 A vitamin D metabolite. SGTC_1316 1272-0050 65.9 µM 1.15609777366956 0.10044176487987 no 385 0.123820583292838 646 7340392 SGTC_1166 k206-0078 225 µM 1.1514698721244 0.101353530414276 no 386 0.124769491456028 692 5404595 SGTC_1676 st018489 23.4 µM 1.15027614674117 0.101589687304948 no 387 0.125015076037271 659 3696235 SGTC_463 ikarugamyin 104 µM 1.15023231044735 0.101598367140709 no 388 0.125024100880848 605 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis. SGTC_440 fluspirilene 35.1 µM 1.14960995864949 0.101721654603017 no 389 0.125152277312668 671 3396 An atypical antipsychotic. SGTC_3000 9075062 71.4286 µM 1.1480875641579 0.102023698925479 no 390 0.125466208702129 623 17057871 SGTC_213 1246-0773 967 nM 1.14235165696385 0.103167568773144 no 391 0.126653938603395 702 6251622 SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM 1.14221912377049 0.10319410853287 no 392 0.126681474394149 721 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_609 0986-0026 86.3 µM 1.14218832412975 0.103200276867965 no 393 0.12668787408586 689 2848610 SGTC_522 1273-0010 11.6 µM 1.13910164736629 0.103819813400309 no 394 0.127330380246087 642 5705015 SGTC_2009 4012297 12.05 µM 1.13832985866824 0.10397514226765 no 395 0.12749138525833 644 45595307 SGTC_1882 5615643 20 µM 1.13571630749815 0.104502392579909 no 396 0.128037656690922 629 2253075 SGTC_491 tetrandrine 80.3 µM 1.13477415834866 0.104692933247633 no 397 0.128234978156327 630 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_599 1935-0052 86.5 µM 1.13476457010162 0.104694873671556 no 398 0.128236987380761 704 9557311 SGTC_577 r071-0003 38.6 µM 1.13407154746162 0.104835193290935 no 399 0.128382268696981 813 4568517 YMR134W ERG29 SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM 1.13346962315432 0.10495717825146 no 400 0.128508545368206 676 5711223 A potent inhibitor of glutathione S-transferases. SGTC_506 n9-isopropylolomoucine 153 µM 1.13190400226573 0.105274945464595 no 401 0.128837397941904 688 6610355 SGTC_1043 0916-0009 19.3 µM 1.131720718195 0.10531219129444 no 402 0.128875934182246 801 3101130 SGTC_3326 9140064 16.379 µM 1.13114076370446 0.105430108785968 no 403 0.128997924703346 663 1868434 SGTC_1696 st025591 34.7925 µM 1.13025605584266 0.10561017324799 no 404 0.129184172778003 696 2787147 SGTC_1744 st037937 38.9 µM 1.12934075604182 0.105796698013781 no 405 0.129377057153795 666 1016152 SGTC_882 0843-0131 351 µM 1.12500994133259 0.106682484204948 no 406 0.130292410812384 736 5425421 SGTC_1586 deoxycorticosterone acetate 53.7 µM 1.12492292614674 0.10670033620107 no 407 0.130310847994297 675 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE. SGTC_3273 9137859 49.47 µM 1.12446872004225 0.106793555918503 no 408 0.130407116593358 668 2377234 SGTC_59 0330-0160 1.33 µM 1.123775444086 0.106935954802793 no 409 0.130554150669379 819 4293482 SGTC_524 r073-0010 27.8 µM 1.12248570461128 0.107201231641355 no 410 0.130827991180516 675 2772106 SGTC_1955 wogonin 32.4 µM 1.12104595301538 0.107497923486619 no 411 0.131134151252613 664 5281703 A flavanone. SGTC_2574 2',4'-dihydroxychalcone 14.64 µM 1.11919006135472 0.107881242411312 no 412 0.131529532256767 725 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_111 0083-0039 52.457 µM 1.11870619630417 0.107981342284049 no 413 0.131632750442763 543 759313 SGTC_563 tetrahydrosecaminediol 614 µM 1.11561618993492 0.108622166767343 no 414 0.132293229509833 720 334274 A psychoactive constituent of the cannabis plant. SGTC_433 pimozide 108 µM 1.11366284759829 0.109028671414942 no 415 0.132711926749355 558 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic SGTC_1847 st056231 15 µM 1.11340145024068 0.109083152935535 no 416 0.132768026212152 743 5393180 SGTC_2017 5132927 60.65 µM 1.11313435586971 0.109138842058236 no 417 0.132825365199554 686 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis SGTC_471 1-acyl-paf 4 µM 1.11197076900097 0.109381688058244 no 418 0.133075359350069 674 16759367 SGTC_3086 9117350 49.47 µM 1.11019835139347 0.109752345375824 no 419 0.133456781520702 629 2679265 SGTC_122 0236-0016 402.397 µM 1.10990797234467 0.109813156829128 no 420 0.133519342364931 764 6808838 SGTC_2477 5967686 25.23 µM 1.10355015450669 0.111150683202405 no 421 0.134894161860868 695 776118 SGTC_3069 9117009 49.47 µM 1.10189964783404 0.111499808019034 no 422 0.135252650862807 563 41904981 SGTC_2356 9061756 188.97 µM 1.10089548130622 0.111712598765822 no 423 0.135471074469872 679 20104043 SGTC_2970 9090938 41.86 µM 1.09949920500434 0.112008963207521 no 424 0.135775190277397 784 17217104 SGTC_2724 maprotiline 69.64 µM 1.09798503304417 0.112330986266785 no 425 0.136105512421357 727 4011 A tricyclic antidepressant. SGTC_1792 st045773 43.6 µM 1.09786259101599 0.112357055226086 no 426 0.136132247614616 685 2919270 SGTC_986 1493-0483 84 µM 1.09687641120465 0.112567179007232 no 427 0.136347710844178 705 40079 SGTC_1525 8-methoxypsoralen 92.5 µM 1.09611765411589 0.112729037127902 no 428 0.136513644871792 783 4114 Related to psoralen; DNA damaging agent. SGTC_1939 st074455 53.6 µM 1.09268681771157 0.113462977909483 no 429 0.137265664779687 728 1644229 SGTC_2199 6590217 200 µM 1.09192154408689 0.113627152648998 no 430 0.137433793639638 641 703109 SGTC_1879 gemcitabine 100 µM 1.08925253905988 0.114201061467979 no 431 0.13802126794427 724 60750 A nucleoside analog which inhibits DNA replication. SGTC_2326 6164455 177.58 µM 1.08826723360315 0.114413449845709 no 432 0.138238575602806 652 2888790 SGTC_2461 5755302 26.15 µM 1.08617252741041 0.114865910096329 no 433 0.138701334670357 747 2788904 SGTC_2647 atorvastatin 60.16 µM 1.08604401440906 0.114893710513924 no 434 0.138729759866952 700 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7 SGTC_2759 disulfiram 3.38 µM 1.08581810957768 0.114942590700009 no 435 0.13877973632932 665 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_2360 9040895 200 µM 1.0837259721978 0.11539598006395 no 436 0.139243158197159 658 4914414 SGTC_2815 7968870 71.43 µM 1.07994365070185 0.116218874008683 no 437 0.140083636838923 749 2977326 YHR190W ERG9 SGTC_3291 9121177 71.43 µM 1.07811762221056 0.116617637620985 no 438 0.14049063415726 623 17015612 SGTC_3042 9091578 49.47 µM 1.07810824103656 0.116619688760703 no 439 0.140492727166033 693 25236497 SGTC_2325 6158266 200 µM 1.07323122927755 0.117689485265384 no 440 0.141583691069671 701 3623240 SGTC_1497 4476-2978 41.3 µM 1.07194840720936 0.117972028760639 no 441 0.141871603015237 792 1528379 SGTC_1081 sertraline 6 µM 1.06904518499815 0.118613238807819 no 442 0.142524654734893 756 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1 SGTC_1340 1486-1359 257 µM 1.06899798065763 0.118623684735976 no 443 0.14253528966358 730 4309068 SGTC_3244 9134489 49.47 µM 1.06729045338455 0.119001983438369 no 444 0.142920348834652 721 16584271 SGTC_2238 6671620 73.2395 µM 1.06708945690589 0.119046569717911 no 445 0.142965721128708 704 729941 SGTC_2874 9043904 71.43 µM 1.06703337720046 0.119059011768545 no 446 0.142978382116306 630 4463428 SGTC_3256 9138902 49.47 µM 1.06696898392437 0.119073299431008 no 447 0.142992920974293 766 17228773 SGTC_2675 theaflavin digallate 100 µM 1.06380545031575 0.11977671943715 no 448 0.143708420885082 758 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative. SGTC_3303 9125618 40.5795 µM 1.06249916386993 0.120068028731679 no 449 0.144004568692315 809 22695467 SGTC_2143 5623677 140.463 µM 1.06092379785181 0.120420008038944 no 450 0.144362266587653 710 5375313 SGTC_1653 st012112 65 µM 1.06087280421041 0.120431413525376 no 451 0.144373855048064 703 720429 SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM 1.06079494108165 0.120448830240103 no 452 0.14439155089083 790 4174840 SGTC_776 4476-4378 112 µM 1.05982002329619 0.12066705365105 no 453 0.144613242803702 705 2892008 SGTC_1509 1326-1131 80 µM 1.05896059571172 0.120859656701951 no 454 0.144808862827752 717 768313 SGTC_1039 k821-0043 94 µM 1.05590506291326 0.121546172151527 no 455 0.145505795407597 772 15992768 SGTC_1958 st076513 41.9 µM 1.05487518373298 0.121778181290376 no 456 0.145741206682219 742 732122 YGL099W LSG1 SGTC_313 3474-0040 5.03 µM 1.05085502766124 0.122686811312729 no 457 0.146662589016066 764 1043375 YIL048W NEO1 SGTC_2426 5582046 32.21 µM 1.04948248641997 0.122998117387946 no 458 0.146978055828779 773 2251934 SGTC_2785 7756463 72.73 µM 1.04726345466365 0.123502586576511 no 459 0.147489043150089 734 2201551 SGTC_3346 9158254 43.5805 µM 1.04517423611339 0.1239788672215 no 460 0.147971224324244 757 17639500 SGTC_253 dyclonine 31.25 µM 1.04240741664566 0.124611597218979 no 461 0.148611414693201 816 3180 An oral anasthetic. SGTC_1623 st003709 20.3 µM 1.04038554915177 0.125075393030342 no 462 0.149080406373534 814 16192618 SGTC_2700 st077718 96.8 µM 1.03874286666608 0.125453094312411 no 463 0.149462169546874 714 904970 SGTC_2492 derrusnin 100 µM 1.03782846430599 0.125663687017925 no 464 0.149674961214633 690 1715307 Part of coumarin class of compounds. SGTC_1861 st057647 17.4 µM 1.03597527142006 0.126091245322815 no 465 0.150106839607444 772 688668 SGTC_1456 k015-0012 13 µM 1.03517460074863 0.126276284964985 no 466 0.150293689103776 850 2989616 SGTC_1220 1838-0075 193 µM 1.03205928907469 0.126998051834947 no 467 0.151022171879659 780 5529645 SGTC_2515 chrysin 20.77 µM 1.02917431494355 0.127669009465561 no 468 0.151698884846066 779 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor. SGTC_2096 5468907 200 µM 1.02598942730744 0.128412575111285 no 469 0.15244828382796 766 759785 SGTC_2646 retinol 96.75 µM 1.02373774018291 0.128940080085021 no 470 0.152979582238667 752 445354 A vitamin A analog and teratogen. SGTC_2797 7859098 81.82 µM 1.02021256194355 0.129768941809612 no 471 0.15381383060838 769 972681 SGTC_1656 st012921 11 µM 1.01789145211594 0.130316705856929 no 472 0.154364772147079 735 6732821 SGTC_3259 9138485 49.47 µM 1.01681102739527 0.130572222563966 no 473 0.154621667598591 850 17646153 SGTC_2115 tiliquinol 12.7705 µM 1.01657712745411 0.130627584676621 no 474 0.154677319790557 768 71208 A bioactive hydroxyquinoline. SGTC_814 3342-0569 96 µM 1.01435862987697 0.131153491067679 no 475 0.155205828585017 805 4346283 SGTC_11 0438-0307 1.3 µM 1.01397012313892 0.131245738883195 no 476 0.155298504376471 771 4011476 SGTC_2445 5742597 35.57 µM 1.01124494294172 0.131894070630413 no 477 0.155949605065818 745 1774255 SGTC_2667 digitoxin 100 µM 1.0106429687102 0.132037580199857 no 478 0.156093671172129 744 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_1835 st008666 49.2 µM 1.01024533692597 0.132132433934625 no 479 0.156188881572722 678 690455 SGTC_1088 bifonazole 369 nM 1.00955965902369 0.132296110450408 no 480 0.156353152642316 779 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase. SGTC_1035 k081-0041 55.2 µM 1.00842084988711 0.13256826152745 no 481 0.156626233840264 826 731709 SGTC_77 0828-0286 12.516 µM 1.00606096391488 0.133133451026154 no 482 0.157193122506102 780 745345 SGTC_1628 st004252 77.7 µM 1.00423534907996 0.13357181944734 no 483 0.157632593696933 797 692968 SGTC_1666 st014829 29 µM 1.00348916626545 0.13375127904145 no 484 0.157812450749077 821 3858230 SGTC_2484 5809818 12.04 µM 1.00345290555796 0.13376000409031 no 485 0.157821194323889 767 2870548 SGTC_2696 st077691 74.316 µM 1.00013488155546 0.134560043116097 no 486 0.158622618744848 723 757133 SGTC_310 1273-0058 1.06 µM 0.996975737603822 0.135324819849543 no 487 0.159388143444757 943 2734232 SGTC_1140 3229-1848 2.98 µM 0.996759153709145 0.135377360159066 no 488 0.159440714573789 826 2849525 SGTC_128 0906-2981 13.371 µM 0.994611950979016 0.135898998754776 no 489 0.15996251637459 743 6740226 SGTC_817 1391-0715 46 µM 0.993361340058886 0.136203453951324 no 490 0.160266947291419 769 1353946 SGTC_2518 prenyletin 46.28 µM 0.99190004119685 0.136559791045759 no 491 0.160623144513565 712 3873459 A coumarin with calcium channel inhibitory activity. SGTC_8 0354-0001 70 µM 0.991142471069597 0.136744774909857 no 492 0.160808008505513 904 4993152 SGTC_3275 9138069 49.47 µM 0.98766266267584 0.137596676447994 no 493 0.161658943083067 808 17617007 SGTC_1106 tegaserod maleate 11.7 µM 0.986929489249354 0.137776627703315 no 494 0.16183860322531 838 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation. SGTC_532 1548-0774 215 µM 0.984840642342149 0.138290197824771 no 495 0.162351176796312 856 5932993 SGTC_1260 0700-1617 7.75 µM 0.983315529162847 0.138665989924687 no 496 0.162726084745321 826 2853078 SGTC_1314 1222-0010 41.1 µM 0.982673997295078 0.138824272811427 no 497 0.16288395617629 823 3526027 SGTC_696 1560-0013 611 µM 0.981053696668716 0.139224591506797 no 498 0.163283131264696 829 1650269 SGTC_1927 st060202 13.8 µM 0.979934296224271 0.139501613955528 no 499 0.16355927616519 816 688887 SGTC_2002 4023503 131 µM 0.976801203189785 0.140278964955657 no 500 0.164333790143591 938 4736863 YCR052W RSC6 SGTC_151 3013-0144 2.285 µM 0.976369891892324 0.140386207429798 no 501 0.164440598044025 824 906558 YHR107C CDC12 SGTC_360 0957-0399 1.01 µM 0.973812178318526 0.141023308425688 no 502 0.165074902588502 848 6752301 YPR165W RHO1 SGTC_113 0099-0221 2.5 µM 0.972018222277569 0.141471333291387 no 503 0.165520741635223 805 89219 SGTC_2927 9011802 47.9 µM 0.971673960571485 0.141557419834173 no 504 0.16560638752161 781 43912568 SGTC_2443 5493264 126.67 µM 0.971203496613329 0.141675122064001 no 505 0.165723476508495 842 5340055 SGTC_2588 indole-3-carbinol 100 µM 0.971006043517086 0.141724541277921 no 506 0.165772634542801 874 3712 Induces cell cycle arrest. SGTC_2025 5147754 141 µM 0.966526656858112 0.14284879427739 no 507 0.166890357369735 837 315777 YLR208W SEC13 SGTC_3335 9143315 29.6265 µM 0.963876801425716 0.143516694919439 no 508 0.167553847926688 829 4899691 SGTC_2262 9014885 67.46 µM 0.962230183218359 0.143932788191925 no 509 0.167966995288018 781 6457424 SGTC_214 4373-3496 70 µM 0.959065044290273 0.14473488840414 no 510 0.168762989364672 1012 3779166 SGTC_2876 9059903 25.97 µM 0.959027409718546 0.144744443721939 no 511 0.16877246856276 882 6916095 SGTC_1317 1273-0028 910 nM 0.958236367223402 0.144945385627435 no 512 0.168971791359661 861 5917803 YLR359W | YHR072W ADE13 | ERG7 SGTC_34 0469-0683 81.75 µM 0.956758754978004 0.145321233924175 no 513 0.169344517292728 856 3690923 SGTC_2398 5228213 48.84 µM 0.954398496759473 0.145922952749355 no 514 0.16994098344628 931 80771 YMR134W ERG29 SGTC_1478 0453-0656 35.7 µM 0.950217838283312 0.146992864086616 no 515 0.171000788246401 877 5258496 SGTC_427 1354-0053 47.3 µM 0.95012091213698 0.147017731599594 no 516 0.171025409249335 831 6813657 SGTC_2738 aclarubicin 5.55 µM 0.950063014905278 0.147032587143308 no 517 0.171040117280302 774 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31 SGTC_3033 9090887 49.47 µM 0.947562677071597 0.147675096000571 no 518 0.171676067104625 880 19325384 SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM 0.946600012536722 0.14792297138653 no 519 0.171921318778317 880 6728940 SGTC_2420 aureobasidin a 50 nM 0.945417558442494 0.148227821096652 no 520 0.172222870771065 894 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1 SGTC_2193 5925765 200 µM 0.943534468548356 0.148714169571324 no 521 0.172703796692223 843 877370 SGTC_2485 5633444 17.78 µM 0.942743734922504 0.14891871116894 no 522 0.172905998639333 822 5724239 SGTC_2595 hexamethylquercetagetin 100 µM 0.941567250583693 0.149223383870828 no 523 0.173207121654781 799 386331 SGTC_186 3455-3465 67.277 µM 0.941307943585031 0.149290592227682 no 524 0.173273536577745 807 755278 SGTC_3262 9137218 49.47 µM 0.940503065976629 0.149499332744088 no 525 0.173479788863137 719 17650664 SGTC_2641 levomentholum 100 µM 0.938847244728995 0.149929373051725 no 526 0.173904589148422 836 16666 SGTC_1917 st066507 28.5 µM 0.936519179182165 0.150535398734533 no 527 0.174502971241082 874 3156428 SGTC_1648 st011736 69.8 µM 0.936120369899572 0.150639377436241 no 528 0.174605608131106 849 2855514 SGTC_2228 7354201 200 µM 0.93348132903591 0.151328640990828 no 529 0.175285753080967 896 753451 SGTC_2415 st077333 57.7 µM 0.932158620800032 0.151674893230869 no 530 0.1756272782959 956 2766255 SGTC_2102 5377816 72.7585 µM 0.929086286383214 0.152481184754555 no 531 0.17642218542297 914 1379702 SGTC_2859 9028643 45.46 µM 0.927352145190191 0.152937539577777 no 532 0.176871864233434 858 17151580 SGTC_2318 6029776 164 µM 0.924738758620359 0.153626984672479 no 533 0.177550906607604 872 818325 SGTC_1130 3454-2858 15.9 µM 0.923676177569985 0.153907894830694 no 534 0.1778274694072 835 715628 YIL048W NEO1 SGTC_303 1348-1668 34.2 µM 0.921835531120393 0.154395302839599 no 535 0.178307185465022 876 5380509 SGTC_1552 6-methylflavone 10.6 µM 0.919989228563812 0.15488523273938 no 536 0.178789194057037 864 689013 SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM 0.918111753374989 0.155384486430584 no 537 0.179280181086095 825 1241132 A phosphatase inhibitor. SGTC_3162 9099653 49.47 µM 0.917196232995655 0.15562832416056 no 538 0.179519910215833 860 25237511 SGTC_3007 9078383 71.4286 µM 0.915051196341858 0.156200616475204 no 539 0.180082376967919 888 6496995 SGTC_3107 9121808 49.47 µM 0.913889488715049 0.156511136255504 no 540 0.180387458710028 875 662681 SGTC_657 3534-0529 86.7 µM 0.912662395999504 0.156839574318738 no 541 0.180710063491608 911 1049549 SGTC_1699 st031318 29.054 µM 0.910455663866416 0.157431358549403 no 542 0.181291126690705 942 5340658 SGTC_1714 st033236 13.627 µM 0.909115133844229 0.157791567066315 no 543 0.181644677452092 913 2916566 SGTC_1096 rimcazole 32.2 µM 0.909036919204563 0.157812600512363 no 544 0.18166531905698 841 18528119 A dopamine reuptake inhibitor. SGTC_1377 2944-0135 198 µM 0.903167927242212 0.159396140127268 no 545 0.183218388566369 928 1894137 SGTC_1678 st019265 80.2 µM 0.903100207217769 0.159414472481789 no 546 0.183236357023036 940 5367020 SGTC_1446 4239-0190 62 µM 0.901029521807588 0.159975690034782 no 547 0.183786311700986 932 1340085 SGTC_1844 rapamycin 4 nM 0.896607423022033 0.16117853162097 no 548 0.184964217845923 970 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2 SGTC_1475 4092-1048 11.7 µM 0.896463335874533 0.161217823333869 no 549 0.185002676814849 925 2881759 SGTC_1831 st055328 12 µM 0.895457374239912 0.161492317210848 no 550 0.185271321113017 930 1103068 SGTC_2909 7941780 10.49 µM 0.89376907539044 0.161953682960622 no 551 0.185722729179924 930 1243215 SGTC_2309 7664088 163.95 µM 0.888277733110723 0.163460248216772 no 552 0.187195687108639 978 704922 SGTC_998 3996-0085 177 µM 0.884924883522084 0.164384573047621 no 553 0.188098573121054 988 715391 SGTC_1929 genistein trimethyl ether 50.5 µM 0.883025327696252 0.164909749717567 no 554 0.1886112935902 946 136420 SGTC_1604 st002052 72.4 µM 0.880602801754935 0.165581088412397 no 555 0.189266420807876 922 6254834 YHR062C RPP1 SGTC_2062 5245942 200 µM 0.878702174312673 0.166109032406292 no 556 0.18978138971602 1016 1376160 SGTC_42 0133-0086 60.653 µM 0.878235227136428 0.16623890420076 no 557 0.189908039285094 888 162923 Model of phenazepam hydroxylation. SGTC_1184 1269-1718 139 µM 0.878067759609404 0.166285497837854 no 558 0.189953473974987 962 5403821 SGTC_2177 5811945 192 µM 0.877909025538029 0.166329669395061 no 559 0.189996545407247 947 5343475 SGTC_3159 9100096 49.47 µM 0.877435609743071 0.166461453673047 no 560 0.190125039274498 948 25236875 SGTC_2745 rifampicin 24.3 µM 0.873891844434933 0.167450068161663 no 561 0.191088578261063 819 25141428 Inhibits bacterial DNA-dependent RNA polymerase. SGTC_939 1165-0479 45.3 µM 0.870476738119414 0.168406362251407 no 562 0.192019963083492 952 1377347 SGTC_3017 9080681 49.47 µM 0.86892869571219 0.168840997802115 no 563 0.192443066436767 924 16451914 SGTC_1748 st037455 53.6035 µM 0.868755587668406 0.168889645181829 no 564 0.192490414885766 918 580690 SGTC_490 phenamil 164 µM 0.867648621731339 0.169200941188283 no 565 0.192793360157746 870 4755 Irreversibly blocks amiloride-sensitive Na+ channels. SGTC_519 k048-0011 62.8 µM 0.867233472052701 0.169317782648799 no 566 0.192907049948622 932 6836379 SGTC_461 N-acetylfarnesylcysteine 136 µM 0.866499584346888 0.169524457739014 no 567 0.193108127105591 938 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ). SGTC_3090 9117696 49.47 µM 0.866332280494523 0.169571595957353 no 568 0.193153984424672 927 7923821 SGTC_953 1188-0045 9.7 µM 0.866186088673076 0.169612792699503 no 569 0.193194060462048 959 6144426 SGTC_2255 7941087 197.44 µM 0.864791526194223 0.170006102037127 no 570 0.193576611477612 1019 935561 SGTC_105 0111-0055 734.78 µM 0.863852311917008 0.170271318409669 no 571 0.193834513284247 847 5179370 SGTC_2658 polymyxin b sulfate 77.05 µM 0.861349283314336 0.170979420121292 no 572 0.194522849944964 960 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides.  YIL048W NEO1 SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM 0.860861412607137 0.171117656819425 no 573 0.1946571881691 934 6710655 SGTC_64 000l-0018 272.079 µM 0.860349319793476 0.171262833646041 no 574 0.19479825680496 990 6811119 SGTC_1159 4092-0538 61.2 µM 0.858949091395782 0.171660196243493 no 575 0.195184301715266 1011 717301 SGTC_2112 5488546 200 µM 0.857489602674874 0.172075002356008 no 576 0.195587179270176 937 600757 SGTC_1759 st043059 70 µM 0.856430434984444 0.172376432196431 no 577 0.195879868061361 962 669426 SGTC_784 4579-0127 173 µM 0.85445996002966 0.172938107714003 no 578 0.196425092796056 1024 1948547 SGTC_2670 beta-carotene 100 µM 0.854170049515305 0.173020843772994 no 579 0.196505387744171 924 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.) SGTC_377 3970-0964 33.1 µM 0.852109627383593 0.173609583240693 no 580 0.197076624516213 1047 16481235 SGTC_2967 9089538 49.85 µM 0.850951739908758 0.173940993667658 no 581 0.197398080839093 1010 728216 SGTC_1913 st060213 96.1 µM 0.849919944076017 0.17423665287501 no 582 0.197684798216775 1020 688959 SGTC_921 1561-0023 372 µM 0.84956435691704 0.174338619676814 no 583 0.197783667736305 1022 24050882 SGTC_974 1326-0144 138 µM 0.847661141118191 0.174885022823236 no 584 0.198313356653649 989 5411856 SGTC_2620 irigenin 100 µM 0.847555359005289 0.174915424153886 no 585 0.198342822240466 994 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro. SGTC_2355 9061122 103.12 µM 0.846219734992046 0.175299565292486 no 586 0.198715087280733 989 5302957 SGTC_2468 5987765 72.9 µM 0.845720171346513 0.175443383014199 no 587 0.198854433816192 1028 26772094 SGTC_3205 9113483 49.47 µM 0.8448184184764 0.175703174952396 no 588 0.199106114679444 971 17018033 SGTC_3332 9141069 11.198 µM 0.843936826579907 0.175957394068113 no 589 0.199352354002097 925 17332883 SGTC_681 1642-0006 26.6 µM 0.842867879162259 0.176265951971334 no 590 0.199651169826019 994 4446530 SGTC_2836 9010338 19.48 µM 0.840825703549215 0.176856389154925 no 591 0.200222792665098 958 2994051 SGTC_348 k064-0012 10.7 µM 0.840759174847154 0.176875645044592 no 592 0.200241431158283 927 5066323 SGTC_2991 9074669 71.4286 µM 0.840025511523716 0.177088082467115 no 593 0.200447041339304 999 17333109 SGTC_1998 st075797 76.8 µM 0.83941458262934 0.177265104207605 no 594 0.200618351746905 1042 24208315 SGTC_1451 4152-0210 104 µM 0.839312975353715 0.177294556597564 no 595 0.200646851939159 1015 659563 SGTC_3228 9131799 49.47 µM 0.836602586374832 0.178081343792861 no 596 0.201407995655959 945 17015818 SGTC_514 4466-0038 2.65 nM 0.836509983869131 0.178108263807541 no 597 0.201434031246223 995 5722064 SGTC_1928 4'-methoxychalcone 40.3 µM 0.834453586971933 0.178706729652369 no 598 0.202012715592283 1034 641818 SGTC_1325 1431-0015 227 µM 0.833484945197206 0.178989068147862 no 599 0.202285642478844 930 1103340 SGTC_2451 5856223 45.7 µM 0.831479354395391 0.179574546911374 no 600 0.202851443300497 969 2179896 SGTC_429 1112-0049 25.5 µM 0.827227088712684 0.180819858321185 no 601 0.204054180298425 922 2836170 SGTC_1760 st045453 10.4495 µM 0.824495939633399 0.181622546024236 no 602 0.204828910975469 1049 3323419 YIL048W NEO1 SGTC_1524 corynanthine 62.1 µM 0.824405047687935 0.181649297548734 no 603 0.204854723854301 969 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist. SGTC_1791 st048313 56.1 µM 0.823079472696832 0.182039723951813 no 604 0.205231400602378 963 1204976 SGTC_1954 st077032 68.9 µM 0.823023888887744 0.182056106705644 no 605 0.20524720433869 946 698907 SGTC_1089 terbinafine 2.25 µM 0.821210728804154 0.182591022303677 no 606 0.205763123192019 1002 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_581 0958-0271 211 µM 0.820053619596832 0.182932903336217 no 607 0.206092770387185 1077 4591145 SGTC_504 lovastatin 124 µM 0.818018516061387 0.183535166148202 no 608 0.206673307274836 998 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1 SGTC_2302 7771753 200 µM 0.817771706022564 0.183608290348144 no 609 0.206743778482662 1024 2203047 SGTC_1068 loratadine 26.9 µM 0.816976815259318 0.183843921769489 no 610 0.206970838827301 980 3957 A H1 histamine antagonist. SGTC_2920 7982904 15.77 µM 0.809471015952329 0.186078160690646 no 611 0.209122133998632 968 6456808 SGTC_3230 9131665 49.47 µM 0.809442863239274 0.186086572420997 no 612 0.209130227771034 974 15943720 SGTC_1518 st038567 90.8 µM 0.808431702589034 0.186388852691473 no 613 0.209421053959125 1033 77966 SGTC_2935 9038016 29.96 µM 0.806318420941499 0.187021586742267 no 614 0.210029635835792 1044 6463195 SGTC_3071 9117417 49.47 µM 0.804687840339189 0.187510703146286 no 615 0.210499919102966 953 45595590 YGL055W OLE1 SGTC_654 1124-0271 80.9 µM 0.803913601056665 0.187743224034377 no 616 0.210723437250925 1025 5403748 SGTC_945 3381-0768 11.3 µM 0.803108808320567 0.187985109477516 no 617 0.210955923505409 1073 1126236 YIL048W NEO1 SGTC_3057 9095946 49.47 µM 0.801689184481394 0.188412254969298 no 618 0.211366386827557 1086 24540043 SGTC_716 1683-5115 658 µM 0.801318034500815 0.188524027584107 no 619 0.21147377646459 1109 723597 SGTC_1133 3473-0247 50 µM 0.801013199918496 0.18861585974918 no 620 0.21156200209974 959 711311 SGTC_2981 9013952 38.96 µM 0.800908875691939 0.188647294011167 no 621 0.211592200706431 1008 2996344 SGTC_2056 5235370 200 µM 0.798841298839549 0.189270948213897 no 622 0.212191220069279 981 5511916 SGTC_61 0978-8327 98.565 µM 0.798494269369371 0.189375748822537 no 623 0.212291858686711 1103 6150059 YHR072W ERG7 SGTC_1490 4089-0339 670 nM 0.798094617977472 0.189496485145883 no 624 0.212407792227402 1017 742542 SGTC_862 0452-0056 10.2 µM 0.797256382910403 0.189749873209428 no 625 0.212651073171707 1012 1575396 YLR359W | YHR072W ADE13 | ERG7 SGTC_1880 MG-132 525 µM 0.794606256382312 0.190552343446731 no 626 0.2134212889376 1000 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1 SGTC_1529 apigenin 74 µM 0.792939276280489 0.19105817836265 no 627 0.213906601318454 1066 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_2094 5332512 191.667 µM 0.79225038467268 0.191267458553308 no 628 0.214107347657706 1090 755774 SGTC_1531 st059297 52.4 µM 0.791984699742995 0.191348209209112 no 629 0.214184798814072 1056 7566702 SGTC_1142 3253-1408 9.78 µM 0.791902435326949 0.191373216389253 no 630 0.214208783434393 1037 256655 SGTC_2271 7849410 118.62 µM 0.791270803313218 0.19156529000881 no 631 0.214392991100337 1062 972430 SGTC_1991 st073000 8.92 µM 0.791125108328694 0.191609611300021 no 632 0.214435494312489 1066 4301969 YIL048W NEO1 SGTC_1387 3342-1166 1.8 µM 0.790431869281504 0.191820584822274 no 633 0.214637798215114 990 3418228 SGTC_2168 5727979 200 µM 0.790068746230981 0.191931150839918 no 634 0.214743810549477 1010 695210 SGTC_1495 4469-0029 237 µM 0.788465024019369 0.192419928802546 no 635 0.215212374647182 1101 793680 SGTC_1382 3002-2117 298 µM 0.788206307536777 0.192498850920067 no 636 0.215288020128353 1102 1497314 SGTC_619 1652-1634 108 µM 0.788197804497421 0.192501445129573 no 637 0.215290506573148 981 5400454 SGTC_1925 st057770 10.1 µM 0.787834771940078 0.192612223402602 no 638 0.215396679499906 1007 5989122 SGTC_2029 5175081 200 µM 0.787609554674501 0.192680967340696 no 639 0.215462562070494 1113 1380876 SGTC_345 1362-0200 395 µM 0.78311643180695 0.194055552011116 no 640 0.216779371359352 1021 1419823 SGTC_1973 st070275 50.2 µM 0.782305426408966 0.194304298545232 no 641 0.217017549281627 1038 17118334 SGTC_1997 st073024 93.8 µM 0.78184689582294 0.194445022073519 no 642 0.217152278490103 1071 686268 SGTC_2406 ethylparaben 405.7 µM 0.780843665915321 0.194753130695441 no 643 0.217447224171388 946 8434 A possible steroid mimic. SGTC_2985 9022375 71.43 µM 0.780600067820462 0.194827988516733 no 644 0.217518875941872 1122 4939335 SGTC_1956 st077085 54 µM 0.780325828011984 0.194912283489999 no 645 0.217599556949006 1102 24208685 SGTC_1500 4488-1866 171 µM 0.779657434905419 0.195117824947948 no 646 0.217796269684734 1132 2900003 SGTC_2430 5571206 200 µM 0.779122790071613 0.195282331496481 no 647 0.217953693188954 1147 1731771 SGTC_1920 st075728 45.7 µM 0.77473887205156 0.196634409085958 no 648 0.21924698820909 1049 3400306 SGTC_1872 amphotericin b 148 nM 0.773211710520477 0.197106741291526 no 649 0.219698548380949 1099 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1 SGTC_1521 st012942 49.4 µM 0.773161678167299 0.197122227286991 no 650 0.219713351271872 1100 24207259 SGTC_2454 5-benzylidenerhodanine 10.36 µM 0.769769425014819 0.198173912701226 no 651 0.220718339744477 1132 1273210 SGTC_553 k007-0256 45.7 µM 0.768939344751236 0.198431773786998 no 652 0.220964659563659 1113 6287000 SGTC_32 0928-0142 34.1 µM 0.767539822732378 0.198866987781343 no 653 0.221380312841723 1075 2244242 SGTC_980 1473-0395 201 µM 0.766687250194211 0.199132396876501 no 654 0.221633742970703 1036 768876 SGTC_2131 toluylene red 5.2905 µM 0.766353185486399 0.199236450658013 no 655 0.221733090048254 1049 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain. SGTC_2201 6605497 169.863 µM 0.76538255635041 0.199538965948677 no 656 0.222021888517835 1089 670741 SGTC_3124 9127567 49.47 µM 0.764939507841505 0.199677142406524 no 657 0.222153783369368 1052 17592030 SGTC_962 1254-0300 21.5 µM 0.764730533559573 0.199742336569337 no 658 0.222216010205329 1063 7340576 SGTC_3193 9111931 49.47 µM 0.764530719889976 0.199804684849951 no 659 0.222275518561868 1121 17087244 SGTC_48 0382-0018 55 µM 0.764065470909687 0.199949902824265 no 660 0.222414113889844 1162 762596 SGTC_2829 7992743 58.44 µM 0.763637792027353 0.200083450027442 no 661 0.222541560743705 1096 16462845 SGTC_1141 3253-0389 52.6 µM 0.763534610170348 0.200115677667918 no 662 0.222572314820271 1094 5402031 SGTC_2526 patulin 37.61 µM 0.763528117857413 0.200117705569901 no 663 0.222574249980728 1108 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.  SGTC_2272 7805186 180 µM 0.762799553501193 0.200345354255661 no 664 0.222791473724574 1081 2956062 YPR165W RHO1 SGTC_384 k007-0144 5.16 µM 0.758285045580742 0.201759432043767 no 665 0.224140178905977 1096 6824886 SGTC_2993 9054257 71.4286 µM 0.758154944757665 0.201800271889713 no 666 0.224179115027669 1152 6470217 YGL055W OLE1 SGTC_1183 1254-0324 198 µM 0.75718560966308 0.202104710905337 no 667 0.224469335154358 1103 5799357 SGTC_2327 6189656 200 µM 0.756950535532266 0.202178582008632 no 668 0.224539748748788 1104 5349088 SGTC_2188 6126565 140.678 µM 0.756065788949601 0.202456754855517 no 669 0.224804876134108 1060 874518 SGTC_1365 1672-3266 55.4 µM 0.755666382427747 0.202582407047472 no 670 0.224924622327062 1117 6415873 SGTC_2575 plumbagin 510 nM 0.752340610023785 0.203630494790092 no 671 0.22592312602849 1057 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_2076 5212012 200 µM 0.751862416444793 0.203781458702422 no 672 0.226066900909075 1008 604802 SGTC_2491 paeonol 100 µM 0.751457114325456 0.203909463276898 no 673 0.226188800541981 1088 11092 Increases levels of cortical cytochrome oxidase. SGTC_3342 9147791 14.508 µM 0.751409757713851 0.203924422808366 no 674 0.226203046052488 1084 1838168 SGTC_1050 3232-1156 69.3 µM 0.750512912885993 0.204207851549798 no 675 0.226472924819094 1062 700529 SGTC_1871 st057448 67.3 µM 0.749488744264549 0.204531805021296 no 676 0.226781340130293 1161 691747 SGTC_165 k038-0023 64.381 µM 0.748986647960573 0.204690734116555 no 677 0.226932626547285 1149 46368543 SGTC_1343 1487-0095 224 µM 0.748453913109105 0.204859441563264 no 678 0.227093206869662 1110 4560101 YGL055W OLE1 SGTC_2320 7373003 200 µM 0.748426648452102 0.204868078008239 no 679 0.227101426878531 1130 5415828 SGTC_80 0159-0065 512.242 µM 0.748410513753906 0.204873188991785 no 680 0.227106291400253 1052 1548079 SGTC_2084 5306078 60.6385 µM 0.747984591665426 0.205008135620856 no 681 0.22723472578035 1076 679340 SGTC_764 1951-2361 146 µM 0.747767302127005 0.205077000698914 no 682 0.227300263968149 1102 5438930 SGTC_2504 purpurogallin 52.29 µM 0.747101278131043 0.205288167805208 no 683 0.227501214375792 1044 5281571 An antioxidant. SGTC_3216 9129716 49.47 µM 0.744036311772157 0.206261598386169 no 684 0.228427253747115 1089 8056934 SGTC_309 k408-0051 1.48 µM 0.743454844350253 0.206446580194386 no 685 0.228603175210416 1119 3640463 SGTC_2687 chenodiol 100 µM 0.741938157274489 0.206929545070913 no 686 0.229062402860777 1094 5702181 A cholesterol synthesis inhibitor. SGTC_3298 9116858 71.43 µM 0.741473337590733 0.207077693264875 no 687 0.229203246073949 1130 2506942 SGTC_797 k781-0471 270 µM 0.740891279301971 0.207263296422763 no 688 0.229379681764145 1135 23738129 SGTC_3009 9080819 71.4286 µM 0.740006109275161 0.207545742464621 no 689 0.229648143680365 1156 17027216 SGTC_1087 pterostilbene 9.05 µM 0.738028657236281 0.208177542324145 no 690 0.230248517499082 1142 5281727 Similar to reservatol, lowers cholesterol. SGTC_2772 vinpocetine 57.06 µM 0.737780652249093 0.208256860428902 no 691 0.230323876146473 1126 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor. SGTC_2519 cryptotanshinone 88.04 µM 0.736319961464199 0.208724386972924 no 692 0.230768000496974 1122 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE) SGTC_39 0986-0283 58.349 µM 0.730816772696918 0.210491351490149 no 693 0.232445538609554 1181 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2 SGTC_855 0428-0020 25 µM 0.730546386390074 0.210578392838988 no 694 0.232528134950622 1100 6812414 SGTC_3293 9120939 62.045 µM 0.729411648821634 0.210943911879679 no 695 0.232874947158093 1132 934087 SGTC_2961 9083290 32.55 µM 0.728733460831845 0.211162545710936 no 696 0.233082360284337 1096 17741490 SGTC_964 1287-0107 19.4 µM 0.728106243821207 0.211364865695162 no 697 0.23327427600268 1145 51516812 YPR165W RHO1 SGTC_2185 6113692 200 µM 0.727954607324755 0.211413795777415 no 698 0.233320686863538 1135 874150 SGTC_2137 5261020 140 µM 0.727749105250004 0.211480117796776 no 699 0.233383592353055 1151 763655 SGTC_1248 0469-0687 58.6 µM 0.727503625760058 0.211559357759046 no 700 0.23345874751493 1145 4017482 SGTC_2814 7977482 42.97 µM 0.7274545854309 0.211575189896972 no 701 0.233473763143237 1174 6456762 SGTC_1256 0570-0116 285 µM 0.72713278305582 0.211679097508769 no 702 0.233572308905159 1147 410638 SGTC_212 3807-4682 38.772 µM 0.727040183459979 0.211709002767742 no 703 0.233600670015899 1246 3125501 YBL034C STU1 SGTC_3126 9127922 49.47 µM 0.726720576465966 0.211812239597405 no 704 0.233698572900973 1179 45595682 SGTC_2645 abamectin 100 µM 0.726491639073884 0.211886207179043 no 705 0.233768715606485 1142 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels. SGTC_517 1365-0151 113 µM 0.726042918811674 0.212031228426421 no 706 0.233906230063313 1167 768657 SGTC_2999 9069765 71.4286 µM 0.725220877527963 0.212297053272492 no 707 0.2341582684099 1154 2097066 SGTC_1034 k072-0165 12.7 µM 0.724869037077148 0.212410887996346 no 708 0.234266188837859 1159 5835461 SGTC_775 4577-0580 57.3 µM 0.724428905820736 0.212553338593041 no 709 0.234401229561494 1193 2006902 SGTC_1592 4',5'-dihydroxyflavone 8.85 µM 0.723756574279972 0.212771049615689 no 710 0.234607596923818 1180 688669 SGTC_2541 muurolladie-3-one 83.07 µM 0.723429166352433 0.212877116322218 no 711 0.234708128816969 1177 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils.  YMR203W TOM40 SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM 0.723282835612519 0.212924531441848 no 712 0.234753067947348 1172 115019 SGTC_1686 st019653 115.5 µM 0.721566659783075 0.213481078688994 no 713 0.235280471700166 1162 97252 SGTC_3339 9145883 14.936 µM 0.720984369176996 0.213670105082789 no 714 0.235459565899807 1093 2030670 SGTC_96 0929-0093 37.281 µM 0.719449399419807 0.214168862479321 no 715 0.235932034456011 1113 6991579 SGTC_2611 pyromycin 23.93 µM 0.719289172054403 0.214220964140458 no 716 0.235981383047388 1149 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release. SGTC_95 0471-0001 561.058 µM 0.717388861332831 0.214839456573959 no 717 0.236567095287988 1114 4015405 SGTC_865 0488-0499 301 µM 0.714558406602811 0.215762602760756 no 718 0.237440976839205 1198 9634651 SGTC_2055 5235184 200 µM 0.714403156998273 0.21581330348403 no 719 0.237488960197379 1151 2836034 SGTC_2839 9003951 25.97 µM 0.714223121648411 0.215872107271121 no 720 0.237544610808287 1157 2990634 SGTC_2705 st078069 42.8 µM 0.713404114537122 0.216139731458165 no 721 0.237797863881743 1135 1530061 SGTC_1302 1159-0335 255 µM 0.712876054285347 0.216312385755978 no 722 0.237961228963474 1157 649284 SGTC_1100 amiodarone 5.07 µM 0.712258974600232 0.216514246925824 no 723 0.238152211767464 1192 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. SGTC_1921 5740136 50 µM 0.712039300551455 0.216586133733594 no 724 0.238220219956163 1170 1774243 SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM 0.709935280724491 0.217275358733036 no 725 0.238872135428022 1146 2724278 An inhibitor of dopamine biosynthesis. SGTC_893 0958-0369 48.9 µM 0.709740950762998 0.217339080272493 no 726 0.238932396356259 1181 6819948 SGTC_3075 9116269 49.47 µM 0.708909002416261 0.217612001288205 no 727 0.23919047409356 1184 17015205 YNL244C SUI1 SGTC_2290 7904846 200 µM 0.707157666548794 0.218187173705735 no 728 0.239734251470888 1210 2962154 SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM 0.705845754562997 0.218618604199473 no 729 0.240142032354685 1199 551469 SGTC_2651 TUB2.036 5 µM 0.705468479878005 0.218742764209612 no 730 0.240259370395866 1284 15992207 YFL037W TUB2 SGTC_999 SEC7.066 22.7 µM 0.703893826040134 0.219261416191779 no 731 0.240749448312862 1196 740511 YDR170C SEC7 SGTC_2742 clothiapine 36.27 µM 0.702539344728405 0.219708113747561 no 732 0.241171437001471 1129 16351 An atypical antipsychotic. YIL048W NEO1 SGTC_1324 1418-0026 34.4 µM 0.702359624389096 0.219767423377176 no 733 0.24122745907589 1181 1372513 SGTC_55 0767-0285 6.563 µM 0.702273459604117 0.219795861934932 no 734 0.241254320703125 1164 3116166 SGTC_1610 st001799 48.1 µM 0.702169702472509 0.219830109623521 no 735 0.241286668851668 1092 621897 SGTC_768 0384-0033 77.3 µM 0.70207742874787 0.219860569493714 no 736 0.241315438821916 1174 3965305 YMR134W ERG29 SGTC_1295 1013-0063 9.78 µM 0.701923870205656 0.219911265060008 no 737 0.241363320881112 1191 6826038 SGTC_2944 9067346 25.62 µM 0.701570124066515 0.220028075755403 no 738 0.241473644338758 1122 6473075 SGTC_569 4130-2812 160 µM 0.70009669922723 0.220514998876937 no 739 0.241933458530973 1102 743552 SGTC_2015 5119600 184 µM 0.699921167621081 0.220573047989773 no 740 0.241988268622635 1180 2828786 SGTC_399 oxolinic acid 75 µM 0.699302971068844 0.220777558145349 no 741 0.242181355337431 1172 4628 A DNA gyrase inhibitor. SGTC_1905 st060207 84.5 µM 0.697696544250899 0.221309499435287 no 742 0.242683494892801 1144 1948547 SGTC_1617 st002906 78 µM 0.696819379331499 0.221600267002812 no 743 0.242957918285303 1191 5150859 SGTC_1004 4084-0029 199 µM 0.696094365453135 0.221840763406382 no 744 0.243184867476524 1198 716894 YLR208W SEC13 SGTC_1967 st070177 51.4 µM 0.69499128376392 0.222206955551277 no 745 0.24353038197554 1225 5729214 SGTC_876 0720-0963 56.8 µM 0.694663159412851 0.222315950149944 no 746 0.243633210386515 1219 765861 SGTC_725 1497-0963 19 µM 0.694435133845748 0.222391712427442 no 747 0.24370468340154 1217 3549977 SGTC_221 trifluoperazine 10.304 µM 0.693549429613155 0.222686130356155 no 748 0.243982408529973 1230 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1 SGTC_2872 9044037 25.97 µM 0.693483995150163 0.222707890308019 no 749 0.244002933205125 1189 6465195 SGTC_217 ketoconazole 989 nM 0.693338032902686 0.222756433797979 no 750 0.244048720198278 1149 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4 SGTC_2848 9016370 25.97 µM 0.692260210197677 0.223115077997613 no 751 0.244386966523046 1212 7894410 SGTC_488 nitrendipine 139 µM 0.691811756090117 0.223264397360076 no 752 0.24452777644553 1221 4507 Dihydropyridine L-type calcium channel blocker. SGTC_1197 1601-0112 267 µM 0.691548440387456 0.223352098675798 no 753 0.244610475195672 1209 7350313 SGTC_370 0180-0345 38.7 µM 0.690851163662794 0.223584432001647 no 754 0.244829539481097 1145 3989527 SGTC_237 nikkomycin 200 µM 0.690378266535315 0.223742080000486 no 755 0.244978170224066 1236 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine. SGTC_2104 5389443 200 µM 0.689852286669086 0.223917498206366 no 756 0.245143541788552 1243 2244536 SGTC_1908 st060353 56.5 µM 0.689848748208372 0.223918678573976 no 757 0.245144654507368 1229 4227716 SGTC_989 1501-0895 10.3 µM 0.688651045852509 0.224318413888986 no 758 0.245521444891321 1198 2830112 SGTC_76 0433-0009 400.328 µM 0.687732798942369 0.224625154598235 no 759 0.245810530742536 1168 2841569 SGTC_3034 9090421 49.47 µM 0.687046875194033 0.224854442838574 no 760 0.246026594930475 1152 17173761 SGTC_148 3253-0744 288.01 µM 0.686787095241923 0.22494131582162 no 761 0.246108451529801 1198 6893655 SGTC_1719 st032227 49.2 µM 0.686302778191812 0.225103327013371 no 762 0.246261098709138 1229 3125804 SGTC_2329 6138490 200 µM 0.686278422075243 0.225111476238963 no 763 0.246268776616911 1175 720019 SGTC_150 3970-0969 77.2 µM 0.684880991662037 0.22557931729009 no 764 0.246709510858255 1231 6615640 SGTC_3141 9094609 49.47 µM 0.684603738407714 0.225672203348983 no 765 0.24679700368202 1174 25236309 YDL196W YDL196W SGTC_2945 9067681 61.76 µM 0.684342100277129 0.225759877833421 no 766 0.246879584072149 1290 16456930 SGTC_3170 9103054 49.47 µM 0.683739850361388 0.225961763938111 no 767 0.247069727359594 1175 16432970 SGTC_2306 7482397 179.52 µM 0.683094716382053 0.226178138816436 no 768 0.247273496946809 1228 891448 SGTC_867 0518-0118 155 µM 0.683075246589934 0.226184670711896 no 769 0.247279647998434 1245 6848158 SGTC_660 4031-1742 102 µM 0.682701318561074 0.226310140024096 no 770 0.247397798187416 1148 6738706 SGTC_287 k060-0039 29.6 µM 0.681311851377785 0.226776711737955 no 771 0.247837092921594 1239 5861974 SGTC_184 1494-0393 24.714 µM 0.680766943032939 0.226959835552002 no 772 0.248009485056469 1214 3090647 SGTC_561 1550-0330 72.9 µM 0.680314610701149 0.22711191127055 no 773 0.248152637592133 1188 6812934 SGTC_2968 9090663 33.37 µM 0.674565062188638 0.229049928065303 no 774 0.249976068220985 1197 25236811 SGTC_2466 5983409 37.09 µM 0.672175102190753 0.229858240380311 no 775 0.250736114717031 1214 2879657 SGTC_280 3448-3607 3.04 µM 0.671212592341324 0.230184222954077 no 776 0.251042553937148 1216 626179 SGTC_2673 kobusone 100 µM 0.670781242613209 0.230330396236436 no 777 0.251179949244513 1287 6710676 An epoxy ketone and protein crosslinker. SGTC_1519 esterone 74 µM 0.669899746788201 0.230629273761181 no 778 0.251460850590316 1207 698 A steroid. SGTC_3270 9137563 49.47 µM 0.668702350817426 0.231035606384083 no 779 0.25184268381946 1200 17015724 SGTC_361 000s-0510 1.45 µM 0.668176316669219 0.231214240701246 no 780 0.252010525644814 1227 660 SGTC_1588 farnesol 29.9 µM 0.665048535910904 0.232277983898117 no 781 0.253009724872642 1263 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_1891 st059073 26.2 µM 0.664628783806192 0.232420946514411 no 782 0.253143977130429 1284 688754 SGTC_75 0159-0059 199.013 µM 0.661630363927458 0.233443595115581 no 783 0.254104071482321 1348 5377270 SGTC_3108 9121785 49.47 µM 0.661229111182264 0.233580636494976 no 784 0.254232697400197 1222 17140271 SGTC_1032 k061-1018 98.7 µM 0.660915602302353 0.233687741415253 no 785 0.254333219823375 1359 4005393 SGTC_2256 7954252 200 µM 0.658772513397069 0.234420619609384 no 786 0.255020930175443 1205 2972920 SGTC_2505 galangin 7.89 µM 0.658622632974317 0.234471922181396 no 787 0.255069062694201 1197 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_993 3909-8757 62.7 µM 0.658410675930686 0.234544483563121 no 788 0.255137138576788 1237 4288324 YLR208W SEC13 SGTC_2858 9025781 8.96 µM 0.658342300501641 0.2345678938594 no 789 0.255159101268931 1274 4894980 YPL153C RAD53 SGTC_1070 indatraline 8.81 µM 0.658007974387742 0.234682378635054 no 790 0.255266503517035 1241 10314472 A monamine transport inhibitor. YGL099W LSG1 SGTC_1704 st028805 70.8 µM 0.657772377267276 0.234763073757449 no 791 0.255342203274257 1253 2876101 SGTC_554 4483-2211 187 µM 0.656763867309598 0.235108675037099 no 792 0.255666380377543 1246 747107 SGTC_3052 9092717 49.47 µM 0.655613158289305 0.235503348811423 no 793 0.256036528524978 1254 25237534 SGTC_744 1594-0068 283 µM 0.654242247524407 0.235974024877628 no 794 0.256477873516759 1279 668392 SGTC_2951 9072950 58.06 µM 0.654097436904215 0.236023773096755 no 795 0.256524516345754 1269 16488155 SGTC_2160 5660466 132.927 µM 0.652421074791687 0.236600090766383 no 796 0.257064786276976 1208 2859134 SGTC_1259 0671-0132 43 µM 0.651611751879978 0.236878605328054 no 797 0.257325832302845 1226 X1259 SGTC_615 k087-0205 167 µM 0.651376660593878 0.236959541722485 no 798 0.257401686497428 1233 9642773 SGTC_432 NS 1619 61.3 µM 0.650867550868838 0.237134868305369 no 799 0.257565994877006 1276 4552 A K+/calcium channel activator. SGTC_2136 5328288 199.296 µM 0.650763551591536 0.237170692213792 no 800 0.257599565956795 1241 262395 SGTC_400 oxethazaine 37.5 µM 0.648557446466731 0.237931313955336 no 801 0.258312234061193 1251 4621 A local anesthetic. SGTC_312 4092-0653 6.84 µM 0.647337333850563 0.238352558537982 no 802 0.258706821974312 1279 1148278 SGTC_3115 9123671 49.47 µM 0.646431640114196 0.238665513754948 no 803 0.258999927554702 1337 3286988 SGTC_3187 9109394 49.47 µM 0.645404827116415 0.239020592561739 no 804 0.259332438030707 1211 17098090 SGTC_1027 k015-0025 8.67 µM 0.645111025022317 0.239122244407051 no 805 0.25942761985102 1251 3598955 SGTC_1851 st056236 18.9 µM 0.644447868518631 0.239351775082671 no 806 0.259642526169411 1291 5393171 SGTC_1465 k213-0056 144 µM 0.643799606788683 0.239576266673488 no 807 0.259852694394292 1212 24048857 YMR208W ERG12 SGTC_450 aminopyrene 156 nM 0.643651015497685 0.239627739693714 no 808 0.259900880458344 1265 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1 SGTC_2737 bleomycin 30.5 nM 0.641376007496096 0.240416570922189 no 809 0.260639208615012 1303 16211318 Bleomycin acts by induction of DNA strand breaks. SGTC_899 1083-0020 478 µM 0.640287143576207 0.240794621069793 no 810 0.260992968729212 1337 767123 SGTC_2114 5491910 81.25 µM 0.63985450955141 0.240944919995788 no 811 0.261133595349223 1334 2849228 SGTC_1793 st048256 72.231 µM 0.639372037475641 0.241112593039081 no 812 0.261290467623763 1213 672022 SGTC_133 0724-0033 378.92 µM 0.639092408644955 0.241209801199887 no 813 0.261381409053175 1179 280309 SGTC_2886 9058944 51.95 µM 0.638615641373907 0.241375590263039 no 814 0.26153650170608 1162 4949929 SGTC_839 0122-0028 230 µM 0.637807332986717 0.241656809445205 no 815 0.261799552764679 1284 759448 SGTC_2167 5876490 200 µM 0.637575397815801 0.24173753501416 no 816 0.261875057413159 1375 686534 SGTC_2404 5161160 200 µM 0.637314634349639 0.241828311812684 no 817 0.261959960217795 1251 2831543 SGTC_2704 st078022 71.1 µM 0.637053174736866 0.241919349521331 no 818 0.262045103850601 1311 54697681 SGTC_1370 2001-0092 44.6 µM 0.636979545285666 0.241944989938835 no 819 0.262069083646616 1394 790957 SGTC_182 3448-4371 550.524 µM 0.636800308401925 0.242007412816247 no 820 0.262127462596657 1323 3491403 SGTC_2079 5212404 121 µM 0.633927770261442 0.243009023202894 no 821 0.263063980667619 1314 758462 SGTC_1640 st009078 66.4 µM 0.632081348340819 0.243654024418485 no 822 0.263666861133041 1322 690618 SGTC_1838 st055369 84.5 µM 0.632022077618736 0.243674744461529 no 823 0.263686225453893 1256 676036 SGTC_2118 5526350 200 µM 0.630988254568106 0.244036304502584 no 824 0.264024102128922 1314 743594 SGTC_2297 7971671 152.32 µM 0.630932277246634 0.244055889766161 no 825 0.264042403073469 1338 909016 SGTC_2643 anethole 100 µM 0.630812889959834 0.244097663648054 no 826 0.264081437113145 1278 637563 An anti-fungal, anti-helmenthic and channel blocker. SGTC_2352 9027995 87.8 µM 0.629346034951815 0.244611234146593 no 827 0.264561269709646 1288 2997347 SGTC_1198 1612-1005 86.7 µM 0.629228292087834 0.244652483109978 no 828 0.264599804575085 1365 6998509 SGTC_884 0851-0618 334 µM 0.628587973837132 0.244876871938441 no 829 0.264809417802026 1286 9642473 SGTC_1813 st051246 8.6015 µM 0.628014089741703 0.24507807410642 no 830 0.264997354993068 1253 5291959 SGTC_2315 7733312 200 µM 0.627983875007658 0.245088669771646 no 831 0.265007251677484 1279 726316 SGTC_2722 naftopidil 47.16 µM 0.625029323976399 0.246125957059184 no 832 0.265975906152387 1300 4418 An a1-adrenergic receptor antagonist or alpha blocker.  SGTC_552 k242-0005 476 µM 0.624214578605135 0.246412412451054 no 833 0.266243336940128 1315 4088318 SGTC_1214 0358-0031 63.7 µM 0.624053879987251 0.246468933382502 no 834 0.266296100477398 1449 4301366 SGTC_2288 7946289 167.31 µM 0.623858079301492 0.246537809803879 no 835 0.266360396525304 1362 1246052 SGTC_1780 st038448 24.544 µM 0.621344788635381 0.247422820046163 no 836 0.267186395249263 1396 728868 YDL195W SEC31 SGTC_2191 5911152 200 µM 0.621129583988918 0.247498679341037 no 837 0.267257182794055 1304 2875902 SGTC_1058 3448-5425 97.3 µM 0.620300902366742 0.24779090431661 no 838 0.267529850476579 1246 7279705 SGTC_1665 st014639 11.4 µM 0.620223033946218 0.247818373178159 no 839 0.267555479347797 1365 981133 YIL048W NEO1 SGTC_2158 5657123 3.6195 µM 0.620212807050019 0.247821980938503 no 840 0.267558845423091 1287 2858827 SGTC_2141 5621638 7.665 µM 0.619243488570742 0.248164056376088 no 841 0.267877983285492 1351 2856238 SGTC_2642 cholecalciferol 100 µM 0.617709571045923 0.248705894694758 no 842 0.268383400882835 1317 9821465 A vitamin D precursor, similar to steriods. SGTC_2164 5685496 200 µM 0.616898877974605 0.248992516756599 no 843 0.268650713472779 1300 759046 SGTC_558 k064-0027 21.3 µM 0.616041058046497 0.24929599189474 no 844 0.268933710966224 1352 5088526 SGTC_2279 7948423 32.93 µM 0.615054658209607 0.249645198305339 no 845 0.269259312272259 1398 1247112 SGTC_489 paxilline 115 µM 0.614996814696097 0.249665684194584 no 846 0.269278412007243 1275 105008 A toxic potassium channel blocker. SGTC_536 3852-0578 10.6 µM 0.614993580823396 0.249666829530999 no 847 0.269279479841265 1377 2869208 SGTC_2957 9076800 11.52 µM 0.614520530230025 0.249834399290186 no 848 0.269435705374309 1270 16459615 SGTC_2379 9035213 200 µM 0.614161314148033 0.249961685071033 no 849 0.269554367264031 1393 646551 SGTC_743 1275-0778 158 µM 0.613162321687927 0.250315852131596 no 850 0.269884507743311 1334 2849257 YMR203W TOM40 SGTC_1263 0774-1208 64.8 µM 0.612496897800868 0.250551908582886 no 851 0.270104524927163 1371 906585 SGTC_41 0478-0632 82.643 µM 0.612004366617172 0.250726707969138 no 852 0.270267434261976 1315 3750424 SGTC_3024 9090631 49.47 µM 0.611745557711391 0.250818585162351 no 853 0.270353057434559 1273 25236383 SGTC_2584 androsterone 48.74 µM 0.611494734522528 0.250907644430111 no 854 0.270436051584913 1347 2754130 A steroid. SGTC_1229 0139-0193 12.2 µM 0.611431554288765 0.250930080342966 no 855 0.270456959114753 1358 3090752 SGTC_2142 5622915 118.518 µM 0.611014150657187 0.251078331089849 no 856 0.270595106133269 1305 5322196 SGTC_1892 st058411 7.36 µM 0.610942272431694 0.25110386501323 no 857 0.270618899043663 1344 3934738 SGTC_2918 7977171 22.06 µM 0.60919068375319 0.251726521367326 no 858 0.271199027354167 1277 2236483 SGTC_1715 st032160 10.2275 µM 0.608741212742506 0.251886431089326 no 859 0.271347992604262 1285 5289825 SGTC_1758 st042942 75.2445 µM 0.608477700384324 0.251980206640308 no 860 0.271435345745432 1295 669317 SGTC_2371 9071574 200 µM 0.605673682458387 0.252979206134154 no 861 0.272365731652106 1310 45596039 SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM 0.605330980093405 0.253101444942147 no 862 0.272479550400527 1396 1377 SGTC_468 gf-109203x 121 µM 0.604226345017725 0.253495669579283 no 863 0.272846583902663 1273 2396 A protein kinase C inhibitor. SGTC_135 0933-0004 26.348 µM 0.603841346693415 0.253633144424468 no 864 0.272974563646643 1296 21230617 YGL099W LSG1 SGTC_412 gemfibrozil 100 µM 0.600259337506094 0.254914079614015 no 865 0.274166706836611 1320 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels. SGTC_2930 9013230 14.89 µM 0.600053717003689 0.25498771261644 no 866 0.274235218211314 1350 2995857 SGTC_2804 7954240 19.48 µM 0.599971580872763 0.255017128795147 no 867 0.274262587783199 1350 828705 SGTC_509 pifithrin 175 µM 0.599533251261915 0.255174141880879 no 868 0.274408671687689 1420 4817 A p53 inhibitor. SGTC_2226 7298446 200 µM 0.597963610094267 0.255736813964758 no 869 0.274932107220326 1342 3283010 SGTC_2913 7966556 36.57 µM 0.597454999108404 0.255919275513794 no 870 0.275101821566383 1339 2976516 SGTC_832 4083-0019 164 µM 0.595889511152487 0.256481312227604 no 871 0.275624520349847 1444 1990758 SGTC_923 1900-2434 73.3 µM 0.593027833509444 0.257510362689235 no 872 0.276581262586439 1309 5910570 SGTC_206 4546-0025 72.014 µM 0.591358185370897 0.258111752163084 no 873 0.277140225596249 1359 6620745 YIL048W NEO1 SGTC_1201 1889-3372 45.9 µM 0.591043683778364 0.258225113741107 no 874 0.277245575932439 1297 5392199 SGTC_28 pentachloropyridine N-oxide 1.606 µM 0.590814613079066 0.258307698136713 no 875 0.277322321338025 1317 140250 A respiratory chain inhibitor. SGTC_2756 carbadox 75.1 µM 0.590141596612416 0.258550412683972 no 876 0.277547861682746 1347 2553 A substituted quinoxaline antibiotic. YLR208W SEC13 SGTC_2413 inermin 26.06 µM 0.585758711649218 0.260133926710613 no 877 0.27901883665323 1506 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1 SGTC_1330 1469-0054 61.8 µM 0.58551572503954 0.260221862572091 no 878 0.279100498126484 1394 7102664 SGTC_339 3091-4833 71.4 µM 0.585315312574737 0.260294402550905 no 879 0.279167860281891 1350 3240077 SGTC_2411 st077133 39.94 µM 0.584773864848235 0.26049043349668 no 880 0.279349889898149 1501 1403142 YNL221C POP1 SGTC_1727 st034309 9.9045 µM 0.584745007014133 0.260500883598144 no 881 0.279359593247986 1470 870305 SGTC_2335 9018011 154.17 µM 0.584360565007029 0.260640119695059 no 882 0.279488876200639 1413 6458208 SGTC_1321 1326-2144 215 µM 0.583915979048668 0.260801186304755 no 883 0.279638421016468 1370 3513030 SGTC_693 4161-2696 114 µM 0.583142893301434 0.261081385192444 no 884 0.279898555338087 1433 805759 SGTC_38 0929-0051 58.268 µM 0.579825801443791 0.262285393234857 no 885 0.281016048124977 1406 1379719 SGTC_2313 7726885 200 µM 0.578565818733045 0.262743474570774 no 886 0.281441087073304 1365 726423 SGTC_388 3',4'-dichloroisocoumarin 16.7 µM 0.578081579984633 0.262919633987179 no 887 0.281604521259209 1391 1609 A potent and irreversible inhibitor of serine proteases. SGTC_2483 5729050 27.16 µM 0.576989299061658 0.263317212409324 no 888 0.281973342181355 1456 2865180 SGTC_3077 9117319 49.47 µM 0.57695746904705 0.263328802791704 no 889 0.281984093431325 1375 17154678 SGTC_1139 k015-0024 46.9 µM 0.575705870346189 0.263784758538921 no 890 0.282407003393186 1367 2766652 SGTC_87 0100-0052 35.5 µM 0.57496850134563 0.264053569423514 no 891 0.2826563000198 1438 200187 YGR083C | YDR527W GCD2 | RBA50 SGTC_2563 tomatine 8.54 µM 0.574948633835143 0.26406081413628 no 892 0.282663018477023 1419 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties. SGTC_479 n-linoleoylglycine 10 µM 0.573558249376879 0.264568071009812 no 893 0.283133385590244 1370 6433346 An anti-infammatory. SGTC_2748 diazoxide 86.69 µM 0.57321252625681 0.264694278815081 no 894 0.283250402012447 1382 3019 A potassium channel activatior. SGTC_2211 7117706 200 µM 0.572455439059414 0.264970763854855 no 895 0.28350673324872 1376 822771 SGTC_973 1325-0077 65.9 µM 0.572238606658324 0.265049977154789 no 896 0.283580167878382 1464 2835149 SGTC_856 0433-0016 11.3 µM 0.572153723813356 0.265080989866026 no 897 0.283608917633573 1375 3911780 SGTC_2746 daunorubicin 9.88 µM 0.570940452691624 0.265524470760451 no 898 0.284020004187492 1336 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_2218 6965428 192.983 µM 0.57039841323034 0.265722721286327 no 899 0.284203752777249 1397 675684 SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM 0.5675228557022 0.26677570784889 no 900 0.285179501394814 1401 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_3235 9132602 49.47 µM 0.565560129923719 0.267495637879548 no 901 0.285846418805149 1419 4912240 SGTC_2347 9049783 174.81 µM 0.565045326687875 0.267684630341068 no 902 0.286021467227238 1438 6467988 YPL169C MEX67 SGTC_1296 1068-0102 11.9 µM 0.564474569330916 0.267894243086117 no 903 0.286215601244934 1405 767053 SGTC_2634 4'-methoxyflavone 100 µM 0.56408974231947 0.268035618871274 no 904 0.286346529329448 1408 77793 From seeds of Psoralea corylifolia (Fabaceae) SGTC_320 4092-0846 5.34 µM 0.564054601657457 0.268048530539786 no 905 0.286358486506414 1428 1359356 SGTC_1381 2324-0066 62.1 µM 0.564016003454118 0.26806271296715 no 906 0.286371620440712 1404 10885928 SGTC_1208 2323-2347 50.3 µM 0.560015508949079 0.269534690079885 no 907 0.287734429610226 1406 5412760 SGTC_895 0964-0006 13.7 µM 0.5590128997799 0.269904232685031 no 908 0.288076458229541 1366 6738897 SGTC_1622 st003707 19.4 µM 0.557133919289865 0.270597471358681 no 909 0.288717967103106 1428 10140899 SGTC_2013 4024628 200 µM 0.557050328590269 0.270628332300555 no 910 0.288746521699405 1420 5230760 SGTC_1484 3473-2379 286 µM 0.555943146602488 0.271037259793569 no 911 0.289124860631085 1480 671917 SGTC_1951 sophoraflavanone G 9.2 µM 0.554332063357225 0.271632848612613 no 912 0.289675805400219 1386 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity. SGTC_2524 avocatin b 10.57 µM 0.554282395006462 0.271651220467395 no 913 0.289692798394181 1386 6710748 SGTC_2721 ifenprodil 61.44 µM 0.554102361176098 0.271717818468986 no 914 0.289754397148583 1446 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor. SGTC_3176 9106582 49.47 µM 0.554008453823387 0.271752559842826 no 915 0.289786530081637 1332 17018027 SGTC_2346 9031566 143.75 µM 0.553413600180701 0.271972679500065 no 916 0.289990114123645 1455 4771086 SGTC_889 0919-1524 82.7 µM 0.552312942274303 0.272380200679282 no 917 0.290366982469091 1379 3905452 SGTC_89 0302-0250 142.109 µM 0.552207036876051 0.272419428392893 no 918 0.290403256864971 1456 4203518 YLR208W SEC13 SGTC_946 3434-1334 87.4 µM 0.551467334093375 0.272693494993391 no 919 0.290656676758639 1452 4047976 SGTC_1570 verbenone 133 µM 0.551282587076441 0.272761966789502 no 920 0.290719986658031 1454 29025 A natural terpanoid with antifungal properties. SGTC_1567 st069303 68.4 µM 0.550614811286118 0.273009532065084 no 921 0.290948876693383 1426 5581319 SGTC_709 3807-1509 243 µM 0.549734163123132 0.27333618598279 no 922 0.291250860575742 1444 1886677 YPL242C IQG1 SGTC_130 0136-0219 337.655 µM 0.547425618952849 0.274193399101187 no 923 0.292043179298559 1399 234244 SGTC_546 peri-Naphthalide 147 µM 0.547360290703058 0.274217676219504 no 924 0.292065615291598 1428 223824 A penicillin ester. SGTC_3058 9093861 49.47 µM 0.547009525789548 0.274348044735268 no 925 0.292186093878887 1436 17217477 SGTC_1562 morin hydrate 59.1 µM 0.546771609009362 0.274436488487093 no 926 0.292267825238616 1429 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase. SGTC_1126 isoteolin 1.0172 µM 0.546079691054123 0.274693783662025 no 927 0.292505579670951 1369 133323 SGTC_901 1112-0062 60.1 µM 0.544642484919643 0.275228600016436 no 928 0.292999714479504 1416 1908457 SGTC_3269 9137823 49.47 µM 0.543578226310888 0.275624964366912 no 929 0.293365873268027 1372 17682936 SGTC_3064 1327-0027 10 µM 0.540895139586742 0.276625476662213 no 930 0.294289930600956 1349 16000455 YPR107C YTH1 SGTC_938 3126-1755 342 µM 0.540448006569304 0.276792383645521 no 931 0.294444054175762 1434 1777771 SGTC_1517 deoxycholic acid methyl ester 49.2 µM 0.540332021326718 0.276835686976931 no 932 0.294484039550141 1403 229346 A bile salt which induces apoptosis. SGTC_2986 9022445 71.43 µM 0.540232007015315 0.276873030192005 no 933 0.294518521032229 1482 6459286 SGTC_1559 coumarin 343 70.1 µM 0.537602959391345 0.277855544365549 no 934 0.2954255933456 1487 108770 A hepatotoxic, DNA x-linker. SGTC_1797 st048695 56.8 µM 0.536680031635015 0.278200859371329 no 935 0.2957443257552 1467 592262 YIL048W NEO1 SGTC_2060 5238662 140 µM 0.536144518966037 0.278401318251199 no 936 0.295929337062097 1413 790130 SGTC_3063 1327-0034 4 µM 0.535048197387563 0.278811924599992 no 937 0.296308264805829 1357 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_858 0438-0351 2.77 µM 0.534024545435409 0.279195579802405 no 938 0.296662276068038 1411 2799119 SGTC_3345 9148410 3.559 µM 0.533107045256271 0.279539668238917 no 939 0.29697974119879 1468 4903596 SGTC_2969 9091408 28.7 µM 0.5325142898831 0.279762077641145 no 940 0.29718492366089 1388 4286311 SGTC_2436 5633522 8.09 µM 0.531796610211492 0.280031475088143 no 941 0.297433435396342 1494 5724242 SGTC_1364 1653-0028 37.6 µM 0.530302542976746 0.280592710393803 no 942 0.297951091920461 1444 5718652 SGTC_2080 5212524 12.4 µM 0.530149728775046 0.280650144584655 no 943 0.29800406132129 1481 260183 SGTC_3247 9135149 49.47 µM 0.529677093728813 0.280827817279314 no 944 0.29816791615354 1418 8934436 YOR116C RPO31 SGTC_1974 st069448 26.9 µM 0.529433992141247 0.280919225063392 no 945 0.298252211472937 1481 6323587 YNR016C ACC1 SGTC_703 3875-0075 71.8 µM 0.528468555536232 0.281282377422347 no 946 0.298587083065722 1507 2850814 SGTC_2545 solidagenone 89.61 µM 0.528174885988411 0.281392887189356 no 947 0.298688979270207 1355 6708572 An anti ulcer agent SGTC_2176 5809774 33.9695 µM 0.52598955042078 0.2822159006579 no 948 0.299447733687619 1459 2870539 SGTC_914 3820-6779 408 µM 0.525713950591184 0.28231977579312 no 949 0.299543484714594 1409 2893481 SGTC_3152 9099253 49.47 µM 0.524798444214113 0.282664967311906 no 950 0.299861656592973 1457 25236131 SGTC_3260 9137109 49.47 µM 0.523967729496036 0.282978363572624 no 951 0.300150492598299 1476 17478346 SGTC_897 1000-0139 31.4 µM 0.52371703651089 0.283072973013379 no 952 0.300237682199148 1516 6151020 SGTC_689 0833-0039 98 µM 0.52362911560857 0.28310615722357 no 953 0.300268263302915 1477 5374726 SGTC_2070 5230947 200 µM 0.523504725705442 0.283153109210311 no 954 0.300311531648489 1511 2835538 SGTC_672 1441-0018 53.7 µM 0.5222657119059 0.283620988940542 no 955 0.300742669535979 1405 251141 SGTC_2739 tacrine 100.86 µM 0.522059056780867 0.283699062629869 no 956 0.300814606197365 1434 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders. SGTC_1266 0828-0227 32.9 µM 0.520050274300581 0.28445851046767 no 957 0.301514267558647 1489 3913820 SGTC_628 1636-0253 16 µM 0.519574456305224 0.284638542172482 no 958 0.301680102743161 1509 4456143 SGTC_271 rotenone 740 µM 0.519138873978606 0.28480339788664 no 959 0.30183195068021 1483 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria. SGTC_732 3970-1727 52.7 µM 0.517517712219115 0.285417362227614 no 960 0.302397403908584 1569 1275699 SGTC_808 0711-0032 135 µM 0.516653592983743 0.285744877681767 no 961 0.302698998414987 1528 4252555 SGTC_60 0986-0278 202 µM 0.515775731850667 0.286077784485616 no 962 0.303005527018093 1284 3110598 SGTC_2607 solasodine 47.35 µM 0.512500980167438 0.287321275075347 no 963 0.30415021724683 1463 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity. SGTC_1307 1187-1599 12.2 µM 0.512494045630706 0.287323910972882 no 964 0.304152643259096 1432 1538471 SGTC_1877 wortmannin 25 µM 0.511834793812919 0.287574552437127 no 965 0.304383318500415 1482 312145 A covalent inhibitor of PI 3-kinase. SGTC_754 3474-0146 171 µM 0.50913684086433 0.28860136482585 no 966 0.305328155055487 1378 24762078 SGTC_2708 st078559 56 µM 0.508348092284107 0.288901880149541 no 967 0.305604624308127 1430 17250902 SGTC_1114 scopoletin 1.73284 µM 0.506814458944146 0.289486619722881 no 968 0.306142505094819 1542 5280460 A coumarin with genotoxic properties. SGTC_591 4299-0174 154 µM 0.504073965860093 0.290532889328136 no 969 0.307104700398809 1490 5509088 SGTC_256 clotrimazole 625 nM 0.503798649845617 0.290638097637175 no 970 0.307201438287705 1478 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C SGTC_1546 5-methoxyflavanone 78.7 µM 0.503723140455929 0.290666955648038 no 971 0.307227972394708 1541 147795 SGTC_1168 k815-0004 80.5 µM 0.503112446672561 0.290900398480484 no 972 0.307442608138932 1437 642433 SGTC_1532 4',5'-dihydroxyflavone 78.7 µM 0.502832559682191 0.291007416909787 no 973 0.307540999864499 1478 165521 SGTC_2551 apiole 73.87 µM 0.502054773111224 0.291304910255448 no 974 0.307814496353685 1439 10659 A possible DNA adduct former. SGTC_3325 9138760 55.175 µM 0.501877385161478 0.291372778733651 no 975 0.307876887016766 1440 43844959 SGTC_283 0987-0079 11.7 µM 0.500554824913794 0.291879021569803 no 976 0.308342231213057 1518 411556 SGTC_2888 9058547 12.99 µM 0.50009109368852 0.292056623190855 no 977 0.30850546852717 1415 16476514 SGTC_2024 5144227 134 µM 0.499428068259463 0.29231063863696 no 978 0.308738924843533 1538 3475211 SGTC_2915 7971052 15.16 µM 0.499385389512549 0.2923269930539 no 979 0.308753955005686 1386 5741558 SGTC_244 nsc-207895 1.295 µM 0.497967117598864 0.292870714095691 no 980 0.309253609500002 1400 42640 SGTC_66 0109-0187 42.4 µM 0.497852258722772 0.292914767932018 no 981 0.309294089525221 1444 759417 SGTC_2899 9053889 58.44 µM 0.497241456241647 0.293149091351333 no 982 0.309509395176588 1497 6470052 SGTC_729 4092-0585 94.1 µM 0.496299309021874 0.293510699584834 no 983 0.309841626863951 1448 2169061 SGTC_1212 0520-0165 585 µM 0.493955096494075 0.294411333804076 no 984 0.310668946098691 1696 5403258 SGTC_1679 SEC14.276 6.7 µM 0.493518779298106 0.294579105324065 no 985 0.310823037026949 1576 1005053 YMR079W SEC14 SGTC_1820 st053765 18.6 µM 0.492635732770647 0.294918786916664 no 986 0.311134997578878 1466 3690829 SGTC_1085 doxorubicin 7.67 µM 0.491475271627848 0.295365455877072 no 987 0.311545168870808 1583 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_1118 chelidonine 707.474 nM 0.491455771847563 0.295372964126339 no 988 0.31155206317427 1602 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor. SGTC_779 1360-0071 233 µM 0.491146428867615 0.295492086146219 no 989 0.311661442698364 1658 7566 SGTC_1322 1348-1070 12 µM 0.489327667526465 0.29619290247274 no 990 0.312304868133857 1474 6758089 SGTC_270 tamoxifen 5.46 µM 0.487318180860483 0.296968095654042 no 991 0.313016432783944 1604 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  YIL048W NEO1 SGTC_82 0054-0107 293.755 µM 0.485718594340331 0.297585825630466 no 992 0.313583349135434 1595 3104697 SGTC_3314 9135860 59.4275 µM 0.48549054115386 0.297673943195999 no 993 0.313664210362782 1515 25252478 SGTC_1176 0848-0131 83.3 µM 0.485481981858121 0.297677250657644 no 994 0.313667245421967 1584 6769040 SGTC_1426 4048-4480 71.7 µM 0.485136488788471 0.297810769221984 no 995 0.31378976508359 1570 14224343 SGTC_2674 ligustilide 100 µM 0.483462429139652 0.298458109442445 no 996 0.314383715164738 1503 5319022 A signalling regulator. SGTC_570 0987-0065 62.6 µM 0.483353601686147 0.298500213961666 no 997 0.314422343398138 1466 3104428 SGTC_1815 st051655 58.2 µM 0.4818152667598 0.299095672964553 no 998 0.314968591579392 1524 5984156 SGTC_3174 9107204 49.47 µM 0.481030147161266 0.299399784910854 no 999 0.315247536291215 1555 3938802 SGTC_1239 0337-0584 35.4 µM 0.480005331413732 0.299796952718958 no 1000 0.315611801027643 1660 914301 YML130C ERO1 SGTC_157 1348-1695 65.819 µM 0.47839767141567 0.300420482256327 no 1001 0.316183595337036 1481 5380510 SGTC_3117 9124945 49.47 µM 0.478260278438046 0.300473797167803 no 1002 0.316232482137533 1396 17592065 SGTC_2003 4023581 200 µM 0.47750490988886 0.300766991855751 no 1003 0.316501312709267 1516 16641307 SGTC_431 k089-0097 107 µM 0.476810396363587 0.301036679642671 no 1004 0.316748570968702 1469 5499420 SGTC_2603 homopterocarpin 100 µM 0.476549641099764 0.30113796212182 no 1005 0.316841425289819 1522 101795 A weak amylase inhibitor. SGTC_1555 citronellol 128 µM 0.475170028405769 0.301674086183426 no 1006 0.317332893961098 1603 8842 A terpine precursor. SGTC_881 0833-0569 170 µM 0.475114346260238 0.301695733539108 no 1007 0.317352736756042 1465 5418700 SGTC_292 k038-0015 474 µM 0.473333749527829 0.302388337936437 no 1008 0.31798754372744 1533 46368540 SGTC_220 paclitaxel 373.376 µM 0.471389879212412 0.303145264492283 no 1009 0.318681171020996 1556 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_249 wiskostatin 11.211 µM 0.469940719542678 0.303710105661095 no 1010 0.3191986855582 1566 2775510 A n-wasp and actin depolymerizer. SGTC_1841 st054148 70 µM 0.4697889990944 0.303769269124101 no 1011 0.319252887386725 1472 675442 SGTC_726 3448-4391 34.2 µM 0.467056246122251 0.304835786665693 no 1012 0.32022981850084 1631 1356692 SGTC_606 k015-0008 38.6 µM 0.46683323902708 0.304922893534433 no 1013 0.320309596387516 1632 1970475 SGTC_2217 6934799 96.0675 µM 0.465146001489192 0.305582288755653 no 1014 0.320913452586471 1572 675606 SGTC_1695 st026914 34.495 µM 0.465108757981031 0.305596851147908 no 1015 0.320926787256054 1500 3289191 SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM 0.463314897914363 0.306298622895437 no 1016 0.321569334335726 1596 756377 SGTC_1379 2144-0755 36.5 µM 0.463019115307752 0.306414403677589 no 1017 0.321675332775331 1597 5392327 SGTC_821 1114-0266 29.2 µM 0.46252368812769 0.306608376386368 no 1018 0.321852909568702 1515 3123235 SGTC_2743 auranofin 4.32 µM 0.461767169967902 0.306904677577623 no 1019 0.322124148144527 1563 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold. SGTC_515 4092-1064 102 µM 0.460089165399795 0.307562342278073 no 1020 0.322726110310368 1666 717353 SGTC_826 1683-5028 118 µM 0.459859369870077 0.307652454874875 no 1021 0.322808582670947 1550 722377 SGTC_2912 7964298 10.93 µM 0.459543339752493 0.307776402675902 no 1022 0.322922018388756 1525 2975850 SGTC_2873 9040596 71.43 µM 0.459295630191979 0.307873570322917 no 1023 0.323010942672758 1517 6463863 SGTC_880 0833-0487 87.2 µM 0.458688474872877 0.308111792727829 no 1024 0.323228945763577 1516 76075 SGTC_2047 4141938 200 µM 0.458379089935259 0.308233213571278 no 1025 0.323340055808204 1553 3807862 SGTC_2242 6630449 61.2675 µM 0.456868464812565 0.308826372906701 no 1026 0.323882795851403 1558 691249 YDR170C SEC7 SGTC_293 4049-0273 38.5 µM 0.456611887055119 0.308927169883041 no 1027 0.323975016811446 1506 1380311 SGTC_688 0527-0193 473 µM 0.456543327398989 0.308954106088764 no 1028 0.323999660828856 1573 4007154 SGTC_1169 aniline yellow 25.8 µM 0.453482247258432 0.310157810301585 no 1029 0.325100761929447 1616 6051 A DNA damaging agent. SGTC_3289 9119912 71.43 µM 0.453446319283581 0.310171950326986 no 1030 0.32511369467842 1556 17014829 SGTC_1338 1486-1223 76 µM 0.453062970451096 0.310322840822588 no 1031 0.325251699267641 1614 3444526 SGTC_1910 st062352 60.4 µM 0.452753098283899 0.310444833400317 no 1032 0.325363269967384 1428 2245730 SGTC_3096 9117468 49.47 µM 0.452745040488894 0.31044800592598 no 1033 0.325366171417214 1495 41316311 SGTC_2479 5617353 43.85 µM 0.452591606890193 0.310508418695028 no 1034 0.325421421788034 1619 2731746 SGTC_454 lyso-paf C-16 6.67 µM 0.450871946920978 0.311185865015129 no 1035 0.32604092161858 1451 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM 0.450491949447743 0.311335648416874 no 1036 0.326177878885395 1557 6857784 SGTC_943 3253-1379 105 µM 0.448096858421156 0.312280438324079 no 1037 0.32704164761713 1630 668464 SGTC_2513 baicalein 25.65 µM 0.445486855020444 0.313311411662799 no 1038 0.327983978587327 1478 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2 SGTC_1747 st037496 66.6 µM 0.443762262687462 0.313993442232904 no 1039 0.328607237386823 1549 723305 SGTC_2077 5212015 200 µM 0.442817349904647 0.314367400009826 no 1040 0.328948926446282 1470 780900 SGTC_2049 5262831 67.185 µM 0.442487328936082 0.314498053717962 no 1041 0.329068298737825 1572 763417 SGTC_1688 st021091 57.6 µM 0.441947503154731 0.314711818222784 no 1042 0.329263597362526 1669 3656366 SGTC_2282 7944268 200 µM 0.441039295564188 0.315071597609131 no 1043 0.329592274592304 1639 2970414 SGTC_1682 st012968 530 nM 0.440318668228654 0.315357193438323 no 1044 0.329853160871067 1515 24207270 SGTC_827 3253-0474 693 µM 0.439770519104071 0.315574507379716 no 1045 0.330051660892792 1682 5402065 SGTC_809 3998-0021 90 µM 0.43967226780867 0.315613465889359 no 1046 0.330087245474642 1614 715485 SGTC_1782 st039423 80.636 µM 0.438343513927373 0.316140543217517 no 1047 0.330568643437651 1522 2068169 SGTC_2248 tofa 1.1 µM 0.437750381401424 0.316375942090466 no 1048 0.330783621663675 1586 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_2170 morpholine 200 µM 0.43756301903024 0.316450316814447 no 1049 0.330851541920788 1641 121171 Reacts with secondary amines. SGTC_263 alizarin 107.927 µM 0.437168869570021 0.316606801264611 no 1050 0.330994442216596 1604 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. SGTC_683 panaxydol 45 µM 0.436902872441064 0.316712425481957 no 1051 0.331090894344704 1656 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis. SGTC_1578 josamycin 24.2 µM 0.436746061555395 0.316774700175865 no 1052 0.331147760149364 1514 5282165 A P450 substrate. SGTC_2221 6807166 181.081 µM 0.435802195616398 0.317149649623308 no 1053 0.331490125355459 1621 674925 SGTC_1232 0279-0259 161 µM 0.435471750185807 0.31728096301758 no 1054 0.331610019977942 1560 1560000 SGTC_803 4488-1585 147 µM 0.432732549795566 0.318370359117286 no 1055 0.332604539972447 1647 747204 SGTC_1269 0831-0796 3.05 µM 0.432355127076316 0.318520585821983 no 1056 0.332741663229298 1648 927758 SGTC_3195 9113082 49.47 µM 0.431823789327881 0.318732126361619 no 1057 0.332934744016413 1667 17018038 SGTC_316 k060-0003 58.6 µM 0.431623224351222 0.31881199229778 no 1058 0.333007638075348 1636 6152314 SGTC_164 4100-3994 89.624 µM 0.431453015835227 0.318879776747034 no 1059 0.333069504222937 1703 4615967 SGTC_298 1391-0729 10 µM 0.431123571738455 0.319010992955636 no 1060 0.333189261061984 1572 3237558 SGTC_1794 st048918 76.9 µM 0.430501606961402 0.319258780759249 no 1061 0.333415399003258 1652 672303 SGTC_1996 st072960 66.8 µM 0.43023148107218 0.319366422786267 no 1062 0.333513631972034 1634 1719405 SGTC_1810 st050138 53 µM 0.430101926522006 0.319418054171494 no 1063 0.333560749345622 1649 3444541 SGTC_2954 9074818 52.69 µM 0.429991397285454 0.319462106164941 no 1064 0.333600949525525 1622 16648742 SGTC_1999 st074831 12.5 µM 0.429726466143322 0.319567706201344 no 1065 0.333697314429149 1558 17112523 SGTC_1237 0330-0133 46.1 µM 0.427803018938636 0.32033481954463 no 1066 0.334397269405202 1568 X1237 YHR072W ERG7 SGTC_2870 9038528 12.99 µM 0.427233177111716 0.320562232775681 no 1067 0.334604749295211 1559 6463316 SGTC_2298 7976326 193.81 µM 0.427116660681015 0.320608740606777 no 1068 0.334647179248563 1562 2235818 SGTC_104 0074-0074 590.992 µM 0.427110535096239 0.320611185727528 no 1069 0.334649409964717 1586 3943124 SGTC_1386 3228-0095 33.8 µM 0.426967558127008 0.320668259380333 no 1070 0.334701478657163 1678 870181 SGTC_2074 5212007 75.395 µM 0.426146176765218 0.320996221109439 no 1071 0.335000667086604 1692 758611 SGTC_3055 9094636 49.47 µM 0.425140001821903 0.321398157722612 no 1072 0.335367309362631 1633 25236176 SGTC_3196 9111891 49.47 µM 0.425059831495638 0.321430192361347 no 1073 0.335396529553742 1562 18891510 SGTC_2412 st077135 33.4 µM 0.424816333586394 0.321527497944688 no 1074 0.335485284897153 1674 13258915 SGTC_183 3914-0051 30.55 µM 0.424180049451738 0.321781824865505 no 1075 0.335717254725237 1735 1596232 SGTC_455 paf C-16 10 µM 0.424178708747548 0.321782360841939 no 1076 0.335717743571311 1583 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis. SGTC_796 1234-0020 70.7 µM 0.423921979004891 0.321885001122202 no 1077 0.335811357208007 1543 46495034 SGTC_1957 st077035 62.4 µM 0.423347604672483 0.322114684583926 no 1078 0.336020833290453 1630 705593 SGTC_1230 0170-0365 3.77 µM 0.421430049177397 0.322881977264827 no 1079 0.33672054027546 1655 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1 SGTC_1781 st038725 66.3 µM 0.421284072014869 0.322940419667295 no 1080 0.336773829852975 1592 4270275 YIL048W NEO1 SGTC_3211 9128781 49.47 µM 0.419852744650713 0.323513687365592 no 1081 0.337296515393813 1541 17194361 SGTC_110 0850-0284 111.64 µM 0.419693923854311 0.323577323293456 no 1082 0.337354532223751 1522 3906265 SGTC_2837 9008476 45.46 µM 0.417633730665838 0.324403263453606 no 1083 0.338107465534409 1639 2992805 SGTC_2778 tioconazole 65.09 nM 0.417041961442442 0.324640666259163 no 1084 0.338323857787955 1557 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_317 4495-0002 170 µM 0.416562309827512 0.324833142619075 no 1085 0.338499291188514 1580 15991618 SGTC_510 ag-490 170 µM 0.415846830466435 0.32512033971596 no 1086 0.338761044128096 1703 5328779 SGTC_3098 9119039 49.47 µM 0.415844149163838 0.325121416200189 no 1087 0.338762025209787 1606 17161528 SGTC_3194 9111903 49.47 µM 0.414521999637392 0.325652407923755 no 1088 0.339245929448931 1657 17087251 SGTC_2089 5281248 129.67 µM 0.414409904112063 0.325697443175037 no 1089 0.339286968409212 1572 2737878 SGTC_3336 9143619 71.43 µM 0.413866303897301 0.325915874871823 no 1090 0.339486011303234 1654 45595730 SGTC_1821 st053465 65.6 µM 0.412594160187824 0.326427286413037 no 1091 0.339951990278293 1572 675086 SGTC_2382 9035899 200 µM 0.412330337551284 0.326533386040748 no 1092 0.340048657652832 1605 6462679 SGTC_933 2914-0560 114 µM 0.411970565071234 0.326678095735017 no 1093 0.340180499001653 1765 463887 SGTC_1865 st057639 52.2 µM 0.411656555913757 0.326804419565928 no 1094 0.340295586006765 1597 688818 SGTC_2716 st080858 38.6235 µM 0.411351903568396 0.326926998188841 no 1095 0.34040725788058 1672 5296050 SGTC_1975 st070967 30.8 µM 0.410862834753398 0.32712381689349 no 1096 0.340586557817637 1723 261391 SGTC_2763 lisinopril 49.32 µM 0.410000347363017 0.327471029679607 no 1097 0.340902846365947 1627 5362119 A lysine-analog of enalapril and an ACE inhibitor. SGTC_669 0108-0021 26.2 µM 0.409604116896194 0.327630590811716 no 1098 0.341048188216184 1870 17201 SGTC_2564 betulinic acid 100 µM 0.408465655273892 0.328089221893373 no 1099 0.341465920111821 1821 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14 SGTC_1171 0368-0077 21.4 µM 0.406918152075077 0.328713051743927 no 1100 0.342034051728328 1592 3239779 SGTC_2245 6637752 200 µM 0.406367524590992 0.328935136119392 no 1101 0.342236288827091 1755 681890 SGTC_2132 5317594 122.667 µM 0.40567175947703 0.329215845182203 no 1102 0.342491897485949 1665 794577 SGTC_3133 9127736 49.47 µM 0.405551108638208 0.329264532021468 no 1103 0.342536229270018 1759 27243420 SGTC_1117 retinoic acid 1.10837 µM 0.4054274359439 0.329314441290416 no 1104 0.342581673652039 1731 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR). SGTC_269 exalamide 29 µM 0.403055314799199 0.330272320660137 no 1105 0.343453766205435 1665 3316 A derivative of salicylamide. SGTC_101 0490-5701 117.494 µM 0.401651596728527 0.330839676793148 no 1106 0.343970225774261 1716 4661669 SGTC_286 k060-0067 22.9 µM 0.400771838327691 0.33119545667856 no 1107 0.344294057282385 1620 5985051 SGTC_1944 st076371 56.9 µM 0.398938330765534 0.331937428409198 no 1108 0.344969322424406 1586 24208455 SGTC_2373 9071805 200 µM 0.398792696007013 0.331996391233612 no 1109 0.345022979666651 1780 10149009 SGTC_1093 fluphenazine 7.97 µM 0.39805171550858 0.332296454788642 no 1110 0.345296032588022 1651 6602611 An atypical antipsychotic. SGTC_1903 st060211 78.3 µM 0.397995944809654 0.332319043750448 no 1111 0.345316587472591 1747 688960 SGTC_582 0987-0078 156 µM 0.396304794105479 0.333004304194221 no 1112 0.345940095490594 1631 1625765 SGTC_913 3487-1245 167 µM 0.395943299779123 0.333150855484604 no 1113 0.346073428613291 1540 4016153 SGTC_2555 cholic acid 100 µM 0.390825027112042 0.335228549728864 no 1114 0.347963287204063 1675 6708657 Influences liver metabolism. SGTC_629 3448-6466 76.7 µM 0.38995504066441 0.335582213044574 no 1115 0.348284896320772 1639 573744 SGTC_2975 9084847 53.72 µM 0.389884727532678 0.335610802818119 no 1116 0.348310893844327 1621 27211724 SGTC_1017 4239-0030 168 µM 0.389704468318373 0.335684101726063 no 1117 0.348377546003767 1562 1149593 SGTC_2692 st077426 47.7 µM 0.389151691983424 0.335908916459954 no 1118 0.348581968273332 1738 25238571 SGTC_115 0527-0192 112.043 µM 0.388985996729879 0.335976316342249 no 1119 0.348643252620489 1642 4233931 SGTC_2073 5212005 126 µM 0.388356831156554 0.336232290138483 no 1120 0.348875992905083 1703 691789 SGTC_2260 7964312 200 µM 0.388113258263215 0.336331407310206 no 1121 0.348966110415869 1749 231951 SGTC_3025 9087895 49.47 µM 0.387469953382239 0.336593242196299 no 1122 0.349204162395863 1734 17173641 SGTC_447 ml7 120 µM 0.387320858822173 0.336653937269313 no 1123 0.349259342618396 1722 4216 Selective myosin light chain kinase inhibitor. SGTC_1189 1431-2119 7.28 µM 0.387143712234528 0.33672605760553 no 1124 0.349324909099909 1654 3107275 SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM 0.386896942432475 0.336826533117378 no 1125 0.34941625240799 1615 6312947 SGTC_1988 st071872 53.4 µM 0.381618062064836 0.338978676620456 no 1126 0.351372342415693 1758 16414116 SGTC_36 0335-0881 14.2 µM 0.380590710258228 0.339398131366554 no 1127 0.35175348778971 1670 23828853 SGTC_1209 2323-2347 50.3 µM 0.380399113152002 0.339476380080196 no 1128 0.351824586417634 1714 5412760 SGTC_391 gliotoxin 8.33 µM 0.379633844719554 0.33978898652583 no 1129 0.352108616980517 1709 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion SGTC_3110 9122132 49.47 µM 0.379172456846297 0.339977513302851 no 1130 0.352279901691194 1751 918317 SGTC_1677 st019204 53.9 µM 0.378402427265102 0.34029224267275 no 1131 0.352565832659964 1590 3945625 SGTC_2671 danthron 100 µM 0.377932810747131 0.340484240737837 no 1132 0.352740253766408 1651 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin. SGTC_2693 st077581 40.7 µM 0.377364134141743 0.340716793888352 no 1133 0.352951508397291 1677 25238761 SGTC_1235 benzylparaben 21.5 µM 0.377064672330383 0.340839279377942 no 1134 0.353062772092007 1668 7180 SGTC_2048 5246248 200 µM 0.375485985371987 0.34148526906105 no 1135 0.353649533664531 1764 677046 SGTC_954 1189-0853 2.85 µM 0.372488388386203 0.342713146145029 no 1136 0.354764627880245 1656 2828194 SGTC_81 0411-0046 9.971 µM 0.372296359387417 0.342791861988091 no 1137 0.354836104458657 1628 12925265 SGTC_2299 7976368 114.88 µM 0.371735735483857 0.343021709982632 no 1138 0.355044807787181 1777 2979718 SGTC_1643 st009866 20.2 µM 0.371707297715949 0.343033370620523 no 1139 0.355055395468033 1753 3156273 YOR207C RET1 SGTC_2431 5490079 200 µM 0.371574616129551 0.343087777426376 no 1140 0.355104795700812 1632 5722345 SGTC_3315 9136395 68.55 µM 0.371249070418147 0.343221282996398 no 1141 0.35522601374846 1804 16876844 SGTC_1602 st001878 87.6 µM 0.371149546677599 0.343262101366926 no 1142 0.355263074674839 1731 595405 YLR310C CDC25 SGTC_649 1123-0311 367 µM 0.370501301386189 0.343528015485375 no 1143 0.355504503537462 1748 693629 YIL048W NEO1 SGTC_995 3931-2021 34.6 µM 0.370190271305373 0.343655629402355 no 1144 0.35562036243996 1708 730143 SGTC_486 niguldipine 82 µM 0.369478816216171 0.343947602457696 no 1145 0.355885430055907 1692 1236 A calcium channel blocker. SGTC_2108 5365811 200 µM 0.366919834228811 0.344998547898486 no 1146 0.356839408099982 1733 780283 SGTC_134 0269-0018 6.916 µM 0.365432876517465 0.345609775229116 no 1147 0.357394151870586 1627 4378915 SGTC_2960 9079389 5.97 µM 0.364501146176545 0.345992976703949 no 1148 0.357741909028744 1802 16457355 SGTC_1427 4048-4900 550 nM 0.363319924041362 0.346479015786339 no 1149 0.358182955773427 1783 24132586 SGTC_857 0438-0306 1.35 µM 0.362989086109722 0.346615191486246 no 1150 0.358306518568443 1690 4686136 SGTC_2828 7998861 71.43 µM 0.361073031201718 0.347404245297468 no 1151 0.359022426596233 1815 2988188 SGTC_216 k038-0035 28.382 µM 0.360936430579032 0.347460524341027 no 1152 0.359073484520789 1758 4444231 YPR107C YTH1 SGTC_2773 thioridazine 9.09 µM 0.358913163116744 0.348294497594739 no 1153 0.359830026049658 1717 5452 An antipsychotic. SGTC_3229 9132204 49.47 µM 0.357862440280768 0.348727886260982 no 1154 0.360223130022972 1738 17682924 SGTC_2532 xanthone 78.9 µM 0.356905625053591 0.349122712936093 no 1155 0.360581229228304 1757 7020 An insecticide. SGTC_1736 st036774 51 µM 0.355101410440315 0.349867660396932 no 1156 0.361256810021183 1877 1272247 SGTC_290 2043-6722 48.1 µM 0.354747042899723 0.350014044285132 no 1157 0.361389552431226 1714 773758 YLR208W SEC13 SGTC_1946 st076057 65.1 µM 0.354448070517254 0.350137562607068 no 1158 0.361501557368455 1660 953009 SGTC_3142 9086498 49.47 µM 0.354338455414325 0.350182853283365 no 1159 0.361542625783654 1825 25236367 SGTC_541 4513-1321 94 µM 0.354003437279108 0.350321289001463 no 1160 0.361668153627643 1650 747515 SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM 0.35293856170843 0.350761447366353 no 1161 0.362067250345429 1812 23847180 SGTC_1597 7-benzyloxygramine 47.5 µM 0.35160698896889 0.351312124925331 no 1162 0.362566511533348 1665 260807 SGTC_1241 0364-0022 50.8 µM 0.348919458854169 0.352424514639711 no 1163 0.363574888060379 1742 4563895 SGTC_2362 9071156 126 µM 0.34809041689012 0.35276791702187 no 1164 0.363886140526091 1761 653133 SGTC_1059 3448-6867 171 µM 0.346435105847065 0.35345393195973 no 1165 0.36450787298215 1847 3934407 SGTC_3354 9151612 71.43 µM 0.346350660705547 0.353488941571642 no 1166 0.364539600030029 1813 27261949 SGTC_714 4296-0578 26.1 µM 0.343243291369616 0.354778067241816 no 1167 0.365707719459583 1826 1589775 SGTC_2383 9036125 200 µM 0.34273081724651 0.354990832962527 no 1168 0.365900488273522 1742 79580 SGTC_1402 3909-7673 35.9 µM 0.342659798663241 0.355020321572184 no 1169 0.365927204817777 1687 5328014 SGTC_650 1328-0195 38 µM 0.342589600177739 0.355049470511144 no 1170 0.365953613487664 1822 2780821 SGTC_416 estradiol valerate 100 µM 0.340624575620847 0.355865763147912 no 1171 0.366693113016344 1740 13791 A steroid. SGTC_518 1021-0119 62.6 µM 0.340149622844038 0.35606316308577 no 1172 0.36687192683614 1648 1097762 SGTC_2250 alverine citrate 130 µM 0.337860199784521 0.357015233878077 no 1173 0.367734270811392 1693 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1 SGTC_3105 9121040 49.47 µM 0.336683008907236 0.357505123310223 no 1174 0.368177936628514 1797 41448907 SGTC_2162 5663267 200 µM 0.335063302633267 0.358179549881297 no 1175 0.368788667311236 1818 6456493 SGTC_1411 3909-8223 150 µM 0.334738630057388 0.35831479304652 no 1176 0.368911129136379 1822 X1411 SGTC_1901 st060216 58.6 µM 0.334007636741059 0.358619355167125 no 1177 0.369186898000871 1677 688792 SGTC_1030 k029-0042 36.7 µM 0.33359939243627 0.358789485820207 no 1178 0.369340938392126 1738 6080581 SGTC_1299 1079-1439 3.74 µM 0.333502807496803 0.358829740472719 no 1179 0.369377385281716 1676 323161 SGTC_291 SEC14.278 35.5 µM 0.332136874017421 0.359399201666086 no 1180 0.369892953802703 1819 1068044 SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM 0.331652715438971 0.359601123690192 no 1181 0.370075754573422 1698 6708561 SGTC_1420 4'-methoxyflavone 42 µM 0.331136377773625 0.359816509446351 no 1182 0.370270737349296 1852 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13 SGTC_2252 omeprazole 400 µM 0.330666363302073 0.36001261060187 no 1183 0.370448256249781 1815 4594 A proton pump inhibitor. SGTC_3116 9124943 49.47 µM 0.330279212379772 0.360174166803633 no 1184 0.370594499294367 1629 41905195 YPL160W CDC60 SGTC_1811 st050069 61.5 µM 0.329805077633843 0.360372054952914 no 1185 0.370773625229218 1838 3877702 SGTC_2840 9008771 71.43 µM 0.328004826307051 0.361123760546025 no 1186 0.371454006730932 1892 2992978 SGTC_196 k015-0023 18.111 µM 0.326953447548879 0.361563018378875 no 1187 0.371851547629357 1725 5211998 SGTC_2552 juarezic acid 87.02 µM 0.324594762779971 0.362549121704288 no 1188 0.372743895741904 1741 1549512 SGTC_405 ebelactone b 50 µM 0.324262979077478 0.362687904995258 no 1189 0.37286947256087 1734 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).  SGTC_1627 st003713 25.6 µM 0.323837930979609 0.362865726627207 no 1190 0.37303036876228 1714 16195070 YER133W GLC7 SGTC_355 1311-2252 105 µM 0.320861685572915 0.36411168483091 no 1191 0.37415760520582 1696 5338538 SGTC_659 k018-0002 107 µM 0.320762742510524 0.364153130547827 no 1192 0.3741950978885 1873 6797879 YHR007C ERG11 SGTC_83 0170-0301 39.027 µM 0.318835129671707 0.364960894169566 no 1193 0.37492576889089 1799 3089716 SGTC_2813 7971799 71.43 µM 0.318364611541636 0.365158155362731 no 1194 0.375104189370868 1767 2234054 SGTC_2937 9044753 11.33 µM 0.316522103806857 0.365930955933169 no 1195 0.375803125259245 1711 6465530 YGL099W LSG1 SGTC_634 1611-4317 11.2 µM 0.315550947518269 0.366338505980524 no 1196 0.37617168738941 1876 2843522 SGTC_3048 9093155 49.47 µM 0.312080168749022 0.367796263306134 no 1197 0.377489798730724 1863 25236002 SGTC_1086 cerivastatin 2.18 µM 0.311351067260695 0.368102735291013 no 1198 0.37776687451873 1826 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7 SGTC_3185 9108267 49.47 µM 0.310359765091541 0.368519555894955 no 1199 0.378143693639347 1699 4910486 SGTC_2476 5806916 10.51 µM 0.30918832624004 0.369012319458438 no 1200 0.378589136729617 1815 2870194 SGTC_1464 k208-0027 110 µM 0.309117975358593 0.369041919288442 no 1201 0.378615893002449 1877 X1464 SGTC_2022 5136654 200 µM 0.308776253379877 0.369185708382734 no 1202 0.37874586704806 1778 1713771 SGTC_2452 5863136 48.41 µM 0.30800286367943 0.369511201329739 no 1203 0.379040076650321 1733 2184096 SGTC_3023 9089636 49.47 µM 0.307764611976754 0.369611492080444 no 1204 0.37913072547356 1867 17249241 SGTC_1933 st074711 15.9 µM 0.307669191659879 0.369651661229182 no 1205 0.379167032385748 1745 17250958 SGTC_300 r073-0011 5.04 µM 0.30661821405913 0.370094185943955 no 1206 0.379566994111271 1835 2735780 SGTC_1283 0922-0125 16.4 µM 0.303961627113007 0.37121353448749 no 1207 0.380578562946857 1833 3360884 SGTC_425 3825-7017 13.1 µM 0.303357031639292 0.371468432440364 no 1208 0.380808893751056 1837 3397440 SGTC_1049 3226-0134 66 µM 0.30229873252193 0.371914747875278 no 1209 0.381212172236192 1789 5702385 SGTC_2257 7960413 200 µM 0.301692626888995 0.372170437782226 no 1210 0.381443194720456 1842 2974689 YIL048W NEO1 SGTC_1952 st077036 64.1 µM 0.301233564302842 0.372364134073006 no 1211 0.381618198577485 1820 2937007 SGTC_2861 9024595 19.48 µM 0.299286107226033 0.373186200199231 no 1212 0.382360876951273 1875 16482810 SGTC_3010 9080089 71.4286 µM 0.298690501468825 0.373437734516156 no 1213 0.382588102565067 1875 17027233 SGTC_1412 3909-8563 178 µM 0.297430970565854 0.373969833084596 no 1214 0.38306875092234 1907 23767530 SGTC_207 4185-0010 4.486 µM 0.296340951121179 0.374430514195253 no 1215 0.383484857572922 1890 3761753 SGTC_1848 st056003 16.4 µM 0.295563093268052 0.374759374364385 no 1216 0.383781881127349 1967 146492 SGTC_3306 9127676 59.7925 µM 0.29507732493138 0.374964792119786 no 1217 0.38396740550357 1765 41905287 SGTC_2488 5268135 45.7 µM 0.294766981881597 0.375096046034741 no 1218 0.38408594547587 1867 1270356 YLR208W SEC13 SGTC_194 1486-1323 56.904 µM 0.294609278571767 0.375162749308216 no 1219 0.38414618666967 1762 5178754 SGTC_969 1313-0238 134 µM 0.292169788658665 0.376195047108536 no 1220 0.385078404746551 1778 5212874 SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM 0.291507722488329 0.376475361140457 no 1221 0.38533151926454 1778 442882 SGTC_2894 9048625 32.47 µM 0.290598271684849 0.376860522235001 no 1222 0.385679291029349 1916 4092861 SGTC_1115 galangin 695.678 nM 0.289329242494185 0.377398173004415 no 1223 0.386164718257251 1913 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_2929 9013348 24.6 µM 0.289309108561358 0.377406705084611 no 1224 0.386172421298868 1793 2995952 SGTC_1501 4491-0275 38.4 µM 0.289214649361794 0.377446734499408 no 1225 0.386208561044248 1905 5104718 SGTC_2798 7813637 45.45 µM 0.287817424983258 0.378038996335571 no 1226 0.386743249152296 1843 956368 SGTC_407 eburnamonine 100 µM 0.285462435284666 0.379037888429312 no 1227 0.387644939947419 1765 3195 SGTC_994 3910-0338 138 µM 0.285403720986042 0.379062803032821 no 1228 0.387667428552294 1882 3479481 SGTC_1222 0366-0074 1.18 µM 0.284588913365787 0.379408607240849 no 1229 0.387979553015124 1926 286520 SGTC_2710 st078562 53.7235 µM 0.282887993462977 0.38013078802333 no 1230 0.388631349324362 1792 17250908 SGTC_3118 9124250 49.47 µM 0.282413519750386 0.380332315940943 no 1231 0.388813224744751 1793 1504786 SGTC_589 1227-0070 34.1 µM 0.282102348823984 0.380464500292232 no 1232 0.388932516122897 1841 2841384 SGTC_1144 3486-0183 12.5 µM 0.28205115580353 0.380486248250732 no 1233 0.388952142629359 1821 6744069 SGTC_2854 9024559 71.43 µM 0.28121159016738 0.380842968661892 no 1234 0.389274057773372 1745 3163529 SGTC_484 loperamide 105 µM 0.281186481393251 0.380853638611922 no 1235 0.389283686417024 1831 3955 An opioid-receptor agonist. SGTC_1493 4348-0038 111 µM 0.280931718788706 0.380961904864322 no 1236 0.389381385923187 1858 800424 SGTC_2663 amphotericin b 100 µM 0.280365404724309 0.381202604256022 no 1237 0.389598588066358 1827 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_356 1634-0012 32.5 µM 0.278929860049075 0.381812956827419 no 1238 0.390149326293439 1974 735457 SGTC_1630 st005209 31.3 µM 0.278211588780027 0.382118455664666 no 1239 0.390424969674451 1969 3367314 SGTC_57 miconazole 162.5 nM 0.277953425274571 0.382228277040716 no 1240 0.390524055822112 1746 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_2905 7799065 20.05 µM 0.276278773093409 0.38294089484604 no 1241 0.391166979141298 1925 1296806 SGTC_2919 7978188 46.38 µM 0.275023648232197 0.383475250453302 no 1242 0.391649034976879 1948 2980291 SGTC_2081 5214970 32.255 µM 0.274986901930454 0.383490898132715 no 1243 0.391663150640895 1921 2063512 SGTC_189 3970-0742 2.116 µM 0.274977145560624 0.383495052720069 no 1244 0.391666898460745 1933 2891807 SGTC_1698 5-fluorocytosine 1.055 µM 0.274899855654239 0.383527965810861 no 1245 0.391696589023617 1940 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM 0.274625953221817 0.383644611035797 no 1246 0.391801812464125 1774 5355888 SGTC_3281 9140613 49.47 µM 0.27395653509992 0.383929736571625 no 1247 0.392059012071668 1726 16013766 SGTC_2086 5274770 176.623 µM 0.273904990156597 0.383951693738124 no 1248 0.392078818301938 1811 689278 SGTC_1005 4092-0690 4.4 µM 0.273550078017492 0.384102889675787 no 1249 0.392215201471004 1777 1529343 SGTC_2037 5169046 200 µM 0.272969209069377 0.384350383408119 no 1250 0.392438442314909 1862 5718022 SGTC_1625 st003711 30.1 µM 0.272712952048205 0.384459583112512 no 1251 0.392536938839717 1901 24207034 YER133W GLC7 SGTC_24 0417-1663 219 µM 0.271970600263004 0.38477597581395 no 1252 0.39282231257095 1811 4329390 SGTC_1657 st012939 43.4 µM 0.271798058512094 0.384849524659289 no 1253 0.3928886490636 1929 24207257 SGTC_2111 5486399 200 µM 0.26864244809457 0.386195385465653 no 1254 0.394102421885257 1803 689674 SGTC_289 k017-0060 526 µM 0.268336169579061 0.38632608579472 no 1255 0.39422028372373 1838 5512909 SGTC_3203 9113543 49.47 µM 0.267615441023732 0.386633698095836 no 1256 0.394497672074705 1864 17018012 SGTC_833 3852-0053 558 µM 0.266948835982515 0.38691827350615 no 1257 0.394754277426171 1882 3123681 SGTC_1812 st052057 4.327 µM 0.266670285175074 0.387037205584704 no 1258 0.394861517314085 1794 3645418 SGTC_193 1273-0060 1.558 µM 0.265734367011745 0.387436889638959 no 1259 0.395221896810883 1927 2847393 YHR072W ERG7 SGTC_26 0302-0163 425.158 µM 0.263194723832034 0.388522044944641 no 1260 0.396200248630077 1871 3100915 SGTC_919 tnp00227 403.569 nM 0.26133258885464 0.389318263866066 no 1261 0.396918018617027 1843 1269246 A methoxyflavone. YNL221C POP1 SGTC_160 3453-0671 289.699 µM 0.261039461260454 0.38944364294176 no 1262 0.397031038118461 1824 5322268 SGTC_1754 st042065 16.137 µM 0.260812318114247 0.389540806492665 no 1263 0.397118622327852 1876 1126236 YIL048W NEO1 SGTC_715 0868-0130 184 µM 0.25887019140024 0.390371858779596 no 1264 0.397867699099676 1993 2876258 SGTC_1612 st002233 45.4 µM 0.258056594794618 0.390720152753311 no 1265 0.398181614791019 1910 1035021 SGTC_700 3453-2283 142 µM 0.257499701499023 0.390958604737173 no 1266 0.398396522853355 1907 565664 SGTC_626 0214-0009 33 µM 0.257387351344879 0.391006716084275 no 1267 0.39843988310897 1927 3437874 SGTC_2581 avocatin a 64 µM 0.257159042075098 0.391104489370965 no 1268 0.398528000320032 1841 6710728 A skin care supplement. SGTC_2895 9054447 58.44 µM 0.256513757791151 0.391380869116511 no 1269 0.398777079279482 1842 2697450 SGTC_1769 st044406 64.4 µM 0.256155425211096 0.391534369146439 no 1270 0.398915413037299 1831 670903 SGTC_3094 9117742 49.47 µM 0.256008538513509 0.391597296335431 no 1271 0.398972122098081 1873 17149698 SGTC_673 1082-0474 110 µM 0.255470789107407 0.391827695767821 no 1272 0.399179751076943 1796 3098046 SGTC_2866 9034245 58.44 µM 0.25440869004131 0.39228286489701 no 1273 0.399589919050529 1990 6462273 SGTC_1356 1502-0781 85.8 µM 0.25351602501956 0.392665536062894 no 1274 0.399934739688221 1835 567702 SGTC_1055 3448-0672 86 µM 0.253330851376488 0.392744930040659 no 1275 0.400006278758792 1871 748378 SGTC_1435 4092-0789 56.7 µM 0.252017747842838 0.393308056549887 no 1276 0.400513672835169 1949 2248285 SGTC_929 2805-0021 398 µM 0.251922368914491 0.393348968665213 no 1277 0.400550534594768 1858 3098024 SGTC_3272 9137413 49.47 µM 0.251320682368822 0.393607084975548 no 1278 0.400783092995175 1790 17614870 SGTC_1931 st074438 57.1 µM 0.25116578794222 0.39367354039899 no 1279 0.400842967072788 1953 2787313 SGTC_2036 5160441 105 µM 0.250017203818345 0.39416642186916 no 1280 0.401287022163341 1898 134534 YIL048W NEO1 SGTC_1243 0416-0003 5.65 µM 0.24619912686159 0.395806052890725 no 1281 0.402764045712489 1851 2141977 SGTC_542 3381-0244 89.3 µM 0.24611530222807 0.395842071263105 no 1282 0.402796488939473 1985 1112843 SGTC_1019 4262-0212 3.4 µM 0.246004848116572 0.395889533339492 no 1283 0.402839239779296 1998 4677213 SGTC_1547 harmine 94.2 µM 0.245692080942053 0.396023937609499 no 1284 0.402960301413752 1861 5280953 A monoamine oxidase inhibitor YHR072W ERG7 SGTC_1926 methyl fluorone black 53.6 µM 0.245497501861064 0.396107559589861 no 1285 0.403035621114524 1894 72721 Reacts with homocysteine. SGTC_1334 1486-0610 236 µM 0.244938246329875 0.396347930915948 no 1286 0.403252123603185 1916 3742339 SGTC_2146 5545642 200 µM 0.243264244914618 0.397067661764544 no 1287 0.403900350474037 1962 825326 SGTC_535 2293-4129 48.2 µM 0.242966291038468 0.397195802791066 no 1288 0.404015755469694 1992 396118 YIL048W NEO1 SGTC_702 1488-0190 94 µM 0.242956748926269 0.397199906750827 no 1289 0.404019451506759 2005 949357 SGTC_3305 9127027 53.8275 µM 0.241503930190302 0.397824880989458 no 1290 0.404582285385123 1874 41905295 SGTC_1022 4477-0945 21.3 µM 0.241079593213164 0.398007472033527 no 1291 0.404746714324857 1817 4648966 SGTC_2423 st077119 87.2 µM 0.240908222165455 0.398081218863118 no 1292 0.404813124714133 1930 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae). SGTC_1023 4482-3888 16 µM 0.240501075782088 0.39825644248966 no 1293 0.40497091468988 1972 3303168 SGTC_2222 6885208 172.143 µM 0.238851741657582 0.398966476138604 no 1294 0.40561027355056 1921 609514 SGTC_903 1134-0042 114 µM 0.238798733470734 0.398989301571907 no 1295 0.405630826184193 1858 701009 SGTC_2884 9058502 51.95 µM 0.238709784678296 0.399027603879304 no 1296 0.405665314496974 1850 6471554 SGTC_127 0180-0333 59.125 µM 0.238386994017005 0.399166609175745 no 1297 0.405790476985495 2005 771601 SGTC_2324 6149169 200 µM 0.237984699666924 0.399339869524011 no 1298 0.405946480610849 1971 2888231 SGTC_652 0437-0092 114 µM 0.237248995551083 0.399656774236533 no 1299 0.40623181408579 1847 3091274 SGTC_949 1165-0505 146 µM 0.237124129399802 0.399710566927653 no 1300 0.406280246781038 1827 6244267 SGTC_2713 st079149 53.4 µM 0.236945543348651 0.399787505611502 no 1301 0.406349518676361 1899 3103253 SGTC_1886 st057356 49.9 µM 0.236842397938425 0.399831944629309 no 1302 0.406389529172859 1820 24207747 SGTC_567 1080-0542 68.4 µM 0.236168675859495 0.400122241953875 no 1303 0.406650892551541 1985 5950415 SGTC_1286 0929-0070 131 µM 0.236114060287851 0.400145777452831 no 1304 0.406672081910735 1950 1420408 SGTC_103 0844-0104 51.839 µM 0.235604710399833 0.40036528915144 no 1305 0.406869708989645 1979 5375804 SGTC_3151 9099821 49.47 µM 0.235327441528799 0.400484795415621 no 1306 0.406977298915371 1836 17174189 SGTC_1652 st011932 78 µM 0.234684797224307 0.400761818750625 no 1307 0.407226694144196 1970 1551076 SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM 0.234129154182864 0.401001378875672 no 1308 0.407442356542852 1937 368090 SGTC_2475 5812728 15.03 µM 0.23377578256776 0.401153751003826 no 1309 0.407579525690735 1942 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2 SGTC_2796 7949634 45.45 µM 0.231480192002908 0.402143963642023 no 1310 0.408470886046141 1864 2971588 SGTC_2054 5233173 129 µM 0.230928169170877 0.402382174971147 no 1311 0.408685303144541 1924 6889 SGTC_1186 1319-0216 26 µM 0.230915097479159 0.402387816165012 no 1312 0.408690380791823 2045 4565136 SGTC_85 0868-0259 160.055 µM 0.230898093445321 0.402395154423218 no 1313 0.408696985964885 1913 83173 SGTC_2770 toltrazuril 17.5 µM 0.230453495050421 0.4025870374372 no 1314 0.408869698262276 2015 68591 Kills coccidiodes. SGTC_2769 toremifene 3.73 µM 0.230431208981901 0.402596656439093 no 1315 0.408878356155196 1915 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_252 miconazole 1.30953 nM 0.230252440118028 0.402673817898874 no 1316 0.408947807504375 1959 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_2456 5770359 74.46 µM 0.229416416905835 0.403034718327049 no 1317 0.409272638776695 1991 3118787 SGTC_2087 5276107 200 µM 0.229288516589328 0.403089938536945 no 1318 0.409322339096728 1888 144405 SGTC_2619 obliquin 87.91 µM 0.228987921688981 0.403219726225482 no 1319 0.409439151915456 1960 6708593 A bioactive alkalod. YER133W GLC7 SGTC_1508 1080-0625 72.9 µM 0.228080532292316 0.403611573840319 no 1320 0.40979181711709 1976 767111 SGTC_806 3966-4455 5.86 µM 0.227633853080636 0.403804503644694 no 1321 0.409965449912583 1847 714982 SGTC_3204 9114183 49.47 µM 0.227238759907996 0.403975171902647 no 1322 0.410119044939149 1835 17027248 SGTC_2843 9000894 45.46 µM 0.227006274326739 0.404075607162488 no 1323 0.410209431659043 1922 2242070 SGTC_1545 lovastatin 49.4 µM 0.226992454988681 0.404081577404198 no 1324 0.410214804549537 1925 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12 SGTC_642 0335-0876 158 µM 0.22580788551329 0.404593418973049 no 1325 0.410675421859691 1909 6812350 SGTC_3297 9117502 71.43 µM 0.2253153964095 0.404806267095588 no 1326 0.410866961496197 2020 7453720 SGTC_1029 k015-0030 64.7 µM 0.224670081340738 0.405085207469255 no 1327 0.411117970612971 1936 2208316 SGTC_2973 9094665 17.96 µM 0.22456010190206 0.405132751395731 no 1328 0.411160753103703 2006 25237061 YIL048W NEO1 SGTC_1180 1193-0155 285 µM 0.224142134126586 0.405313450928559 no 1329 0.411323354061107 1897 2921347 SGTC_3287 9117173 37.0625 µM 0.221059508483337 0.406646779961504 no 1330 0.412523048923422 2032 2789709 SGTC_2472 5377652 49.4 µM 0.220686014952509 0.406808401096549 no 1331 0.412668460729181 1881 1610903 SGTC_1969 st069479 40.1 µM 0.219215116071248 0.407445054432008 no 1332 0.413241240461855 2006 3895485 SGTC_2765 myclobutanil 7.74 µM 0.217827240307554 0.408045996919314 no 1333 0.41378185972567 1920 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11 SGTC_2834 9001755 58.44 µM 0.216551695518018 0.40859849157191 no 1334 0.414278866880464 1879 2989575 SGTC_2310 7668677 200 µM 0.216370248978229 0.408677098850884 no 1335 0.414349577435351 1957 2197143 SGTC_1605 st000082 49.1 µM 0.216049246028889 0.408816174531046 no 1336 0.414474680566497 1990 1114022 SGTC_2148 5546263 113.568 µM 0.215800208516518 0.408924078837492 no 1337 0.414571742887583 1922 792097 SGTC_3277 9138724 49.47 µM 0.215769956549581 0.40893718704202 no 1338 0.414583533941141 1953 15943418 SGTC_3044 9093193 49.47 µM 0.213029982651788 0.410124840802175 no 1339 0.415651788313862 1859 25236277 SGTC_2594 a-mangostin 100 µM 0.212799423528845 0.410224815446241 no 1340 0.415741706701733 2023 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis. SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM 0.212179839805042 0.410493507150066 no 1341 0.415983367085842 1941 364106 SGTC_335 4077-0256 27.6 µM 0.211532802748985 0.410774149248707 no 1342 0.416235769189744 2009 3121989 SGTC_562 3772-2733 112 µM 0.21140132142605 0.410831182784193 no 1343 0.41628706284768 2019 2876874 YIL048W NEO1 SGTC_3245 9134821 49.47 µM 0.211238008575095 0.410902026720105 no 1344 0.416350776646276 1876 17014901 SGTC_1057 3448-5381 134 µM 0.211169886102631 0.410931578616067 no 1345 0.416377354148152 2024 5497911 SGTC_1642 st009582 77.7 µM 0.210552439334932 0.411199453390252 no 1346 0.416618264069981 2059 6739311 SGTC_3313 9133968 57.047 µM 0.210546882577229 0.411201864337222 no 1347 0.416620432298922 1962 1494643 SGTC_1143 3454-2408 5.08 µM 0.210388876501475 0.411270420874521 no 1348 0.416682086821637 1964 X1143 SGTC_362 0310-0100 9.03 µM 0.210368278596705 0.411279358205388 no 1349 0.416690124347073 1913 790235 SGTC_2235 salicylic acid 500 µM 0.210305412245507 0.411306635894626 no 1350 0.416714655693256 2038 338 A COX inhibitor and kinase inhibitor. SGTC_142 0335-0849 62.6745 µM 0.210217483757389 0.411344788756107 no 1351 0.416748967186475 1953 3889043 YPR107C YTH1 SGTC_393 acivicin 6.25 µM 0.209867926367263 0.411496472741439 no 1352 0.416885377894583 1931 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1 SGTC_52 0329-0193 875 nM 0.209285823664496 0.41174909482526 no 1353 0.417112558908404 2013 3739292 SGTC_940 3232-1287 54.8 µM 0.209233428513193 0.411771835172987 no 1354 0.417133008864299 2077 1585493 YIL048W NEO1 SGTC_2880 9042983 58.44 µM 0.208407427385216 0.412130372206044 no 1355 0.417455428719115 1925 6464714 SGTC_1829 berberine 14.4 µM 0.208154236212831 0.41224028798342 no 1356 0.417554270049129 2035 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_2906 7926292 26.41 µM 0.208018690066267 0.412299134334186 no 1357 0.417607186994999 1928 2966319 SGTC_1294 1000-1494 117 µM 0.207450577735162 0.41254579751053 no 1358 0.417828993140086 1889 712797 YDL207W GLE1 SGTC_2159 5658611 73.75 µM 0.206024846095867 0.413164973998848 no 1359 0.418385751619923 2051 793844 SGTC_2028 5153890 36.43 µM 0.205573497735369 0.413361033749682 no 1360 0.418562040544925 1936 2830968 YPR165W RHO1 SGTC_2949 9072542 2.23 µM 0.204990154921463 0.413614462144575 no 1361 0.41878990846647 1900 16457352 SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM 0.204771270120151 0.413709564102512 no 1362 0.418875417239713 1967 6708739 YPR165W RHO1 SGTC_3231 9132313 49.47 µM 0.204729445002805 0.413727737025631 no 1363 0.418891756930488 1956 4905967 SGTC_3081 9117243 49.47 µM 0.203927499513021 0.414076216300813 no 1364 0.419205077552127 2045 45595589 SGTC_1138 3761-0006 1.03 µM 0.199500014155819 0.41600135698857 no 1365 0.420935816140048 2045 12061087 SGTC_2917 7979103 53.79 µM 0.199356152737276 0.416063944297421 no 1366 0.420992078522577 2019 2980565 SGTC_662 k832-1615 104 µM 0.198851433200555 0.41628354075545 no 1367 0.42118948070812 1981 5878478 SGTC_1985 st071382 65.5 µM 0.198405159535419 0.416477729999609 no 1368 0.421364040481102 1967 6123237 SGTC_374 0880-0231 82.3 µM 0.198145072134418 0.416590912509226 no 1369 0.42146578069945 2021 6833587 SGTC_3035 9091303 49.47 µM 0.196969986989897 0.417102361624512 no 1370 0.421925512285293 2001 25237002 SGTC_2180 6301957 200 µM 0.196401319585862 0.417349921309003 no 1371 0.422148031747146 2056 845462 SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM 0.196290181436612 0.417398307243147 no 1372 0.4221915229922 1998 4620898 SGTC_262 fenpropimorph 62.5 µM 0.195050047560365 0.417938305871003 no 1373 0.422676883837779 1995 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_1790 st045711 43.5 µM 0.193767677547301 0.418496858362904 no 1374 0.423178898444096 2087 585119 SGTC_2869 9037858 32.47 µM 0.193461288240003 0.418630334474612 no 1375 0.423298860407205 2082 27187042 SGTC_1217 1183-1422 255 µM 0.193042980480948 0.418812582111165 no 1376 0.423462653777032 2028 2849664 SGTC_1757 st041620 31.8375 µM 0.192653485684635 0.418982292230703 no 1377 0.423615176981591 1926 5289815 SGTC_1568 digitonin 820 nM 0.191774915585582 0.419365156859699 no 1378 0.423959260352337 2108 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1 SGTC_2027 5150920 200 µM 0.191412156066724 0.419523263054279 no 1379 0.424101348489922 2034 786715 SGTC_2401 5128683 200 µM 0.191227285278972 0.4196038426915 no 1380 0.424173763745104 1916 708373 SGTC_131 0141-0277 33.849 µM 0.190862726655346 0.419762752748298 no 1381 0.424316571554466 2055 1547771 SGTC_469 w7 172 µM 0.190838665900975 0.419773241222573 no 1382 0.42432599717468 2081 45115570 A P450 inhibitor. SGTC_1119 parthenolide 318.541 nM 0.190812071020546 0.419784834429931 no 1383 0.424336415570145 2008 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs. SGTC_1624 st003710 6.25 µM 0.188433920520223 0.420821795126781 no 1384 0.425268255604707 2054 24207033 SGTC_1113 artemisinin 1.17947 µM 0.187944227375074 0.421035387742409 no 1385 0.425460186013846 2096 2240 An anti-malaria and mitochondrial poison. SGTC_1366 1683-0113 21.9 µM 0.18778303666741 0.421105700420298 no 1386 0.425523366992001 1948 708623 SGTC_1291 0993-0025 5.79 µM 0.186954901501472 0.421466979239806 no 1387 0.425847996403328 2051 4353356 SGTC_3322 9139058 2.11 µM 0.186800163005701 0.421534492156303 no 1388 0.425908659553217 2040 4908926 YPR165W RHO1 SGTC_564 3555-0129 330 µM 0.185291740534491 0.422192742406481 no 1389 0.426500107980464 2088 563260 SGTC_2064 5220758 200 µM 0.184927624999957 0.422351668956313 no 1390 0.426642901530915 1987 788518 SGTC_2502 avocadyne acetate 18.59 µM 0.182879437308084 0.42324588215584 no 1391 0.427446308721364 2099 3952079 SGTC_1853 st056710 91.2 µM 0.182687223964702 0.423329820475837 no 1392 0.42752172042706 2129 269167 SGTC_2932 9016711 44.54 µM 0.182451173379219 0.423432906995519 no 1393 0.42761433456761 2107 7117328 SGTC_2517 totarol 10 µM 0.18210855372816 0.423582543006946 no 1394 0.427748768037713 1915 460178 An antibacterial membrane disruptor. YGL001C ERG26 SGTC_1157 4092-0394 27.6 µM 0.180636536386387 0.424225558301253 no 1395 0.428326437857696 2056 3659885 SGTC_1764 st044502 93.5 µM 0.179963644025183 0.424519562407056 no 1396 0.428590555010506 1975 8407 SGTC_246 cycloheximide 667 µM 0.178618397075419 0.42510746141362 no 1397 0.429118674011903 1982 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells. SGTC_1569 carminic acid 40.6 µM 0.178422910070112 0.425192906920099 no 1398 0.429195429167766 2093 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_2850 9015429 58.44 µM 0.177830039308497 0.425452066551817 no 1399 0.429428227689856 1980 6457570 SGTC_202 3594-0513 34.79 µM 0.176867496774814 0.425872888135071 no 1400 0.42980623494641 2089 708429 SGTC_1923 st058458 19.1 µM 0.176372539795078 0.426089315195313 no 1401 0.43000063827041 2115 3534982 SGTC_349 k015-0014 24 µM 0.176292836637174 0.426124168630694 no 1402 0.43003194471787 1935 2196908 SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM 0.176149515697438 0.42618684297058 no 1403 0.430088240575957 2093 688798 SGTC_3138 9097216 49.47 µM 0.175556432128865 0.426446218602799 no 1404 0.43032121638691 2154 25237486 SGTC_1924 st058459 75.1 µM 0.175172395652552 0.426614187803679 no 1405 0.430472087008742 2049 688683 SGTC_2629 bisabolol 100 µM 0.174630549679813 0.426851202076985 no 1406 0.430684971126649 2035 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer. SGTC_2788 5282734 71.43 µM 0.1735599269219 0.427319591474422 no 1407 0.43110566381864 2077 743706 SGTC_749 1000-0129 128 µM 0.172988496083446 0.42756963014953 no 1408 0.43133023504775 2107 708470 SGTC_1801 st050089 28.441 µM 0.172982926349878 0.427572067418598 no 1409 0.431332424051776 2045 5008493 YIL048W | YNL267W NEO1 | PIK1 SGTC_3341 9147222 25.867 µM 0.172274237884349 0.427882206113602 no 1410 0.431610968365652 2013 1939759 SGTC_1101 ebselen 5.29 µM 0.168554468227862 0.429510790986794 no 1411 0.43307354855247 2130 3194 A potent scavenger of hydrogen peroxide and hydroperoxides. SGTC_1539 benzyladenosine 56 µM 0.16830479247399 0.429620147008775 no 1412 0.433171751898227 2023 92208 A nucleotide analog. SGTC_2790 5423970 71.43 µM 0.167940703835461 0.429779624654347 no 1413 0.433314963917237 2092 1376240 YKL165C | YIL048W MCD4 | NEO1 SGTC_1367 1812-0510 76.9 µM 0.167649023670562 0.42990739429995 no 1414 0.433429700828742 2064 1142582 YDR527W RBA50 SGTC_3095 9117207 49.47 µM 0.16747135950192 0.42998522316928 no 1415 0.433499590532014 2120 17015229 SGTC_3282 9108498 15.4605 µM 0.167356381749073 0.430035592617611 no 1416 0.433544821700631 1976 16459645 SGTC_3197 9113331 49.47 µM 0.166439788815537 0.43043717425868 no 1417 0.433905431833335 2072 16610459 YLR208W | YDL195W SEC13 | SEC31 SGTC_677 0929-0063 136 µM 0.166336149491945 0.430482585700825 no 1418 0.433946209551849 2123 1539583 SGTC_1362 1611-0397 101 µM 0.166063066029004 0.430602246555329 no 1419 0.434053659783877 2010 27816 SGTC_1280 0880-0253 10.1 µM 0.164583406392135 0.43125072053566 no 1420 0.434635946436681 2016 6836607 SGTC_1423 4048-0112 5.59 µM 0.163142982423584 0.431882177211617 no 1421 0.435202929017312 2114 X1423 SGTC_93 0109-0045 59.227 µM 0.162534552418995 0.432148954673383 no 1422 0.435442460556562 2138 88733 SGTC_1739 st037196 92.5 µM 0.162524209597204 0.432153489943932 no 1423 0.435446532605508 2133 612214 SGTC_2892 9047358 58.44 µM 0.162378111617934 0.432217554060241 no 1424 0.435504053241121 2008 6466771 SGTC_1453 4237-0541 195 µM 0.160723786589926 0.432943101265695 no 1425 0.436155477001291 2125 739892 SGTC_35 0133-0054 64.071 µM 0.159277497416735 0.433577594283944 no 1426 0.436725124441398 1981 99677 SGTC_1268 0828-0275 2.46 µM 0.159114685119627 0.433649031461549 no 1427 0.436789259282151 2061 745337 SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM 0.158892532575436 0.433746508864919 no 1428 0.436876772047539 2115 4000243 SGTC_555 4296-0685 37 µM 0.15747448887976 0.434368821150019 no 1429 0.437435455978849 2123 2908540 YHR072W ERG7 SGTC_1078 idebenone 36.1 µM 0.15647255853326 0.434808619139491 no 1430 0.437830273958302 2056 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen. SGTC_1767 st044992 70.3 µM 0.156122071216608 0.434962484853941 no 1431 0.437968400682608 2020 9600693 SGTC_3037 9091026 49.47 µM 0.156040185129977 0.434998434682672 no 1432 0.43800067300275 2113 25236398 YIL048W NEO1 SGTC_2194 5927483 104.545 µM 0.155241657108354 0.435349034520183 no 1433 0.438315404363696 2116 760979 SGTC_1452 4194-0072 190 µM 0.152739292162363 0.436448044963715 no 1434 0.439301936815708 2137 1343545 SGTC_1206 3978-0017 132 µM 0.15036957626362 0.437489250052151 no 1435 0.440236521476854 2048 3873677 SGTC_813 k007-0158 173 µM 0.149915279706966 0.437688908429927 no 1436 0.440415728246583 2113 6523916 SGTC_1073 triclabendazole 3.09 µM 0.149622398057401 0.437817635132741 no 1437 0.440531268006423 2035 50248 An antihelmetic and likely tubulin inhibitor. SGTC_774 k060-0086 136 µM 0.149285678192084 0.437965637643891 no 1438 0.440664107891568 2158 5911235 SGTC_211 3455-0679 143.504 µM 0.149171467652083 0.438015839941014 no 1439 0.440709166789188 2040 748649 SGTC_3073 9114972 49.47 µM 0.14841287216621 0.438349312870338 no 1440 0.441008471024974 2164 41905075 SGTC_585 0kpi-0023 191 µM 0.147194886290071 0.438884821871015 no 1441 0.441489098392046 2138 64601 SGTC_2004 4023728 41.89 µM 0.14638905759513 0.439239180251147 no 1442 0.441807132514847 2164 360084 YDR527W RBA50 SGTC_16 erodoxin 22.806 µM 0.14456283162287 0.440042432072558 no 1443 0.442528022480161 2111 3967339 Erodoxin inhibits Ero1. YML130C ERO1 SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM 0.144559380578945 0.440043950223104 no 1444 0.442529384936609 2033 279621 SGTC_1069 diphenylcyclopropenone 8.49 µM 0.144451979043858 0.440091197729317 no 1445 0.442571786913915 2073 65057 A dermal irritant. YDR527W RBA50 SGTC_1694 st024011 44.9 µM 0.144175387095698 0.440212878498911 no 1446 0.442680988059381 2142 2787533 SGTC_3344 9148862 3.898 µM 0.143611925541304 0.44046077893279 no 1447 0.442903461531124 2123 4905352 SGTC_1116 jasmonic acid  1.58368 µM 0.143019898952561 0.440721271975028 no 1448 0.443137232828183 2123 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid. SGTC_315 k915-0449 187 µM 0.142705786530186 0.440859492577018 no 1449 0.44326127325333 2073 20970215 YNL149C PGA2 SGTC_3120 9124077 49.47 µM 0.142563454995122 0.440922125871562 no 1450 0.443317480643093 2183 18774327 YGL155W CDC43 SGTC_2817 7995342 71.43 µM 0.140782794092289 0.441705833881408 no 1451 0.444020768001396 2024 18879975 SGTC_14 0354-0009 295 µM 0.140442513798776 0.44185562479211 no 1452 0.444155184768227 2092 1713507 SGTC_2740 felodipine 17.08 µM 0.139487315256474 0.442276146222398 no 1453 0.444532539454458 2168 3333 L-type calcium channel blocker SGTC_1787 fluconazole 80 µM 0.138451247005698 0.442732343676413 no 1454 0.444941898851742 2082 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C SGTC_2124 5246320 200 µM 0.13771220080487 0.443057804001748 no 1455 0.44523393821541 2073 579342 SGTC_331 k048-0133 24.5 µM 0.135573070195003 0.444000047696443 no 1456 0.446079397864747 2069 6813582 SGTC_1401 3807-4679 7.6 µM 0.135324773978192 0.444109437760308 no 1457 0.446177549218671 2131 3291456 SGTC_19 0279-0214 38.434 µM 0.13427450929272 0.444572192257208 no 1458 0.446592754662357 2163 3566274 YBR002C RER2 SGTC_2066 5222451 176 µM 0.134047818823489 0.444672083714192 no 1459 0.446682380833952 2163 2281147 SGTC_2416 tofa 880 nM 0.132402311251681 0.445397283754694 no 1460 0.447333043328942 1897 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_1522 st012842 45.6 µM 0.132103033055294 0.445529199888679 no 1461 0.447451398454323 1990 3491067 YOR116C RPO31 SGTC_2764 methyldopa 94.69 µM 0.131784413377089 0.445669648007698 no 1462 0.447577407670655 2154 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent. SGTC_1351 1496-0003 46.5 µM 0.130138986523535 0.446395063222793 no 1463 0.448228232799915 2164 3891978 SGTC_1649 st011737 51.3 µM 0.130019217629607 0.446447872470027 no 1464 0.44827561114084 2057 1761035 SGTC_2841 9004761 38.96 µM 0.128736537985907 0.447013498940751 no 1465 0.448783061413929 1959 2991039 SGTC_1417 3966-0327 90.4 µM 0.128330511927804 0.447192567790323 no 1466 0.448943709852582 2084 651118 SGTC_1922 5578187 25 µM 0.128297826978431 0.447206983235988 no 1467 0.448956642357612 2165 1350412 SGTC_1836 st055642 81 µM 0.127747974018593 0.447449502098028 no 1468 0.449174211657425 2047 8571 SGTC_476 mead acid 10 µM 0.127303394498728 0.447645603289821 no 1469 0.449350136873296 2124 5312531 An omega 9 fatty acid. SGTC_1621 st003705 32.4 µM 0.127123127635497 0.44772512150324 no 1470 0.449421473378085 2179 24207032 SGTC_927 2425-1185 123 µM 0.126636054746056 0.447939986608223 no 1471 0.449614229548399 2102 730375 SGTC_2377 9073351 62.6 µM 0.126168806104695 0.448146120891791 no 1472 0.449799151565908 1998 7337946 YHR072W ERG7 SGTC_2978 9011784 42.97 µM 0.125287001320892 0.448535181416878 no 1473 0.450148171270226 2197 2994934 SGTC_27 0485-0001 32.618 µM 0.12510623106049 0.448614945074191 no 1474 0.450219725191889 2180 2054479 SGTC_2113 5491891 107.031 µM 0.124646503276041 0.448817806207205 no 1475 0.450401705584064 2086 789979 SGTC_3258 9138477 49.47 µM 0.123705439476032 0.449233105074516 no 1476 0.450774252333594 2203 4970355 SGTC_2495 cafestol 54.53 µM 0.122541840027567 0.449746687535139 no 1477 0.451234956054494 2118 16667697 An anti-infammatory. SGTC_1964 st076914 61 µM 0.122226947938273 0.449885687203744 no 1478 0.451359642543552 2196 24208661 SGTC_3343 9148379 18.9835 µM 0.121258687845677 0.45031313502947 no 1479 0.451743070411123 2199 1955036 SGTC_3261 9137475 49.47 µM 0.12123298432675 0.450324482885244 no 1480 0.451753249536546 2199 17027690 SGTC_2204 7233102 200 µM 0.120459303775849 0.450666074356218 no 1481 0.452059657862328 2142 2172480 SGTC_2403 6032726 181.2 µM 0.119913576277059 0.450907043159359 no 1482 0.452275804883361 2105 2881040 SGTC_1565 sinapyl alcohol 95.1 µM 0.119202594679595 0.451221007896008 no 1483 0.452557425525597 2071 5280507 A phenol propionate derived from cinnamic acid. SGTC_2098 5376439 882.5 nM 0.118356756849567 0.451594563981154 no 1484 0.45289249395662 2153 2844116 SGTC_2229 7354935 190 µM 0.118344928831124 0.45159978801561 no 1485 0.452897179721515 2188 318112 SGTC_556 4058-0063 51.5 µM 0.117841010972198 0.451822359210962 no 1486 0.453096816929262 2096 6615692 SGTC_1305 1181-0477 144 µM 0.117828174863066 0.451828028880969 no 1487 0.453101902367439 2188 6252086 SGTC_1008 4106-0037 6 µM 0.117498684971734 0.451973566914402 no 1488 0.45323244303351 2168 2905394 SGTC_2766 oltipraz 83.91 µM 0.117496746464095 0.45197442318616 no 1489 0.453233211066209 2182 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40 SGTC_3014 9081533 49.47 µM 0.117359522982638 0.452035037696654 no 1490 0.453287579168715 2209 21367265 SGTC_155 k072-0202 43.6 µM 0.116924387329606 0.45222725369373 no 1491 0.453459986204585 2194 5857737 SGTC_1181 1222-0449 220 µM 0.116536236081986 0.452398724339619 no 1492 0.453613784743156 2165 658318 SGTC_3213 9129884 49.47 µM 0.116182310800897 0.452555082978238 no 1493 0.45375402787072 2083 17190742 SGTC_621 3584-0052 32.1 µM 0.115625612709763 0.452801038343548 no 1494 0.453974631521537 2198 2273927 SGTC_1472 k841-0093 193 µM 0.115451461951225 0.452877983795407 no 1495 0.454043645442767 2176 X1472 SGTC_410 α-linolenic acid 100 µM 0.114156226780276 0.453450316017341 no 1496 0.454556975483883 2165 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_3085 9117376 49.47 µM 0.113057315507132 0.453935973461057 no 1497 0.454992557621956 2104 16480349 SGTC_2280 7785178 200 µM 0.112705252436873 0.454091580291332 no 1498 0.455132118471832 2124 2954328 SGTC_2966 9084041 48.03 µM 0.11131296075969 0.454707022064716 no 1499 0.455684089038835 2076 17741380 SGTC_3347 9188721 44.724 µM 0.110985493024629 0.454851790144165 no 1500 0.455813925272904 2121 44118411 YKL104C | YBL026W GFA1 | LSM2 SGTC_1223 0764-0573 147 µM 0.11075303530806 0.454954559503365 no 1501 0.455906094269543 2173 1609797 SGTC_3330 9141424 71.43 µM 0.10957582801836 0.455475047999474 no 1502 0.456372890823211 2205 27261020 SGTC_2926 9010726 65.15 µM 0.108100705690405 0.456127363952504 no 1503 0.456957904187892 2088 2994293 SGTC_2528 xanthyletin 44.79 µM 0.108000241715008 0.456171794592163 no 1504 0.456997750235693 2116 65188 An natural product with antifungal activity of unknown mechanism. SGTC_457 grayanotoxin iii 135 µM 0.107775645238575 0.456271125363437 no 1505 0.457086831311087 2137 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity. SGTC_494 Boc-Gly-Val-Val-CHO 140 µM 0.105522765442198 0.457267641508011 no 1506 0.457980503311144 2220 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA. SGTC_1856 st057054 55.7 µM 0.105049533829469 0.45747700037459 no 1507 0.458168251906107 2221 1266018 SGTC_645 0845-0943 5.41 µM 0.104897028371995 0.457544471693096 no 1508 0.458228758488142 2127 1885106 SGTC_1025 k007-0731 70 µM 0.104708231503559 0.457628000717745 no 1509 0.458303665038139 2106 6256118 SGTC_2808 7946468 45.46 µM 0.104654196988585 0.457651907445858 no 1510 0.458325103903152 2160 2970879 SGTC_258 haloperidol 50.781 µM 0.104345813877587 0.457788349672036 no 1511 0.458447461051575 2057 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_924 2046-0044 21.3 µM 0.102687283706415 0.458522241153866 no 1512 0.459105583210225 2236 3623589 SGTC_1753 st043925 64 µM 0.101060234594842 0.459242339846406 no 1513 0.459751322288345 2213 670181 SGTC_1046 2001-0062 216 µM 0.099993903625245 0.459714348843422 no 1514 0.460174582695198 2143 739778 SGTC_3080 9117754 49.47 µM 0.099138484943507 0.460093039073113 no 1515 0.460514158008524 2243 9550191 SGTC_333 3486-0131 40.1 µM 0.0983004544756746 0.46046406672298 no 1516 0.460846858655813 2228 6744690 SGTC_2020 4017018 200 µM 0.0975940288505898 0.460776854706036 no 1517 0.461127333079417 2149 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope. SGTC_1378 2093-0007 380 nM 0.0973034681379754 0.460905514935662 no 1518 0.461242700948212 2142 3618014 SGTC_1738 st035555 74 µM 0.0970498103188626 0.461017837917191 no 1519 0.461343419096464 2165 5331140 SGTC_824 1304-0008 100 µM 0.0970471597180771 0.461019011654128 no 1520 0.461344471565207 2149 768245 SGTC_1646 st011709 75.6 µM 0.0970311324200153 0.461026108856779 no 1521 0.461350835498103 2242 5757843 SGTC_2231 micatex 6.853 µM 0.0962115415926387 0.461389056285208 no 1522 0.461676282237887 2167 20737 An antifungal of unknown mechanism. SGTC_2661 dactinomycin 12.96 µM 0.0953327595558645 0.46177825165769 no 1523 0.462025261389239 2238 45006140 An Actinomycin D Classic transcription inhibitor. SGTC_1438 4092-1045 4 µM 0.0953146514344646 0.461786271776585 no 1524 0.462032452737665 2239 1351342 SGTC_1749 st037932 54.2 µM 0.0953053483883507 0.461790392118154 no 1525 0.462036147297248 2138 594497 SGTC_3013 9080133 71.4286 µM 0.0949839203630384 0.461932755881645 no 1526 0.462163799430965 2190 17050193 SGTC_596 1155-0152 116 µM 0.0931709244862576 0.462735841135037 no 1527 0.462883886394098 2217 280313 SGTC_1943 st076331 65.2 µM 0.0926567631159175 0.462963622018278 no 1528 0.463088123607879 2267 24208415 SGTC_1466 k213-0079 57.5 µM 0.0925915467446277 0.462992514678314 no 1529 0.463114029809384 2199 3657981 SGTC_2947 9072639 7.68 µM 0.0919807620674581 0.463263118674742 no 1530 0.463356662216664 2174 16488146 SGTC_1496 4469-0713 57.4 µM 0.0909306393265669 0.463728408081138 no 1531 0.463773852186427 2248 746691 SGTC_375 3970-0961 9.27 µM 0.0900664369873613 0.464111356941554 no 1532 0.464117210096768 2175 2898222 SGTC_1709 st033179 39.1045 µM 0.0898584173326933 0.464203540436688 no 1533 0.46419986279041 2256 573381 SGTC_2602 kawain 100 µM 0.088410626574359 0.464845178982395 no 1534 0.464775157793014 2282 5369129 SGTC_3323 9138564 53.9225 µM 0.0881395315399549 0.464965334334792 no 1535 0.464882888499933 2243 43912313 YNL103W MET4 SGTC_3015 9080845 49.47 µM 0.0879156586043018 0.465064562210933 no 1536 0.464971855514246 2229 5296973 SGTC_1827 berberine 7.24 µM 0.0877510960986917 0.465137503132087 no 1537 0.465037253704487 2132 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_682 0kpi-0099 17 µM 0.0869852296533752 0.46547698224698 no 1538 0.46534162631574 2141 1714895 YML126C ERG13 SGTC_341 1486-1430 230 µM 0.0867174901208581 0.465595666815513 no 1539 0.46544803684155 2250 2054753 YPL210C SRP72 SGTC_2457 5731572 11.68 µM 0.0860603872657991 0.465886962745407 no 1540 0.465709206566569 2273 2865357 SGTC_1213 1315-0166 115 µM 0.08580822935992 0.465998750063618 no 1541 0.465809432263623 2026 768401 SGTC_3084 9116877 49.47 µM 0.0856499188720645 0.466068934064525 no 1542 0.465872357352057 2270 27241325 SGTC_1817 st052116 64.4 µM 0.0848257205481444 0.466434344011869 no 1543 0.466199972595339 2235 4361398 SGTC_441 propafenone 146 µM 0.0841061076922159 0.466753408934823 no 1544 0.466486034308363 2256 4932 Slows the influx of sodium ions into the cardiac muscle. SGTC_1211 1056-0033 32.3 µM 0.0828296488844502 0.46731942295192 no 1545 0.466993496862132 2259 6741922 SGTC_1231 0242-0792 125 µM 0.0824881075200475 0.467470882258201 no 1546 0.467129287464972 2195 3707635 SGTC_1265 0819-1001 68.8 µM 0.0821459926859214 0.467622600595796 no 1547 0.467265309904218 2268 3106768 SGTC_3217 9129673 49.47 µM 0.0819427781530053 0.467712722772044 no 1548 0.467346108376496 2213 17248312 SGTC_1098 clofazimine 15.1 µM 0.0813926759814545 0.467956691984698 no 1549 0.467564836753612 2245 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2 SGTC_2521 angolensin 13.4 µM 0.081319363728258 0.467989206733229 no 1550 0.467593987479827 2186 821428 A flavenoid. SGTC_3167 9103034 49.47 µM 0.0813073974812583 0.467994513908793 no 1551 0.46759874556575 2243 5127859 SGTC_798 1287-0182 476 µM 0.0804479003548705 0.468375726120753 no 1552 0.467940515676631 2259 1649755 SGTC_1394 3474-0001 65.7 µM 0.0792421275456407 0.468910570564551 no 1553 0.468420018493687 2200 5017666 YIL048W NEO1 SGTC_2286 7945697 125 µM 0.0791367102161172 0.468957333193019 no 1554 0.46846194226597 2187 1245733 SGTC_1109 tnp00067 928.257 nM 0.0789590500844047 0.469036143355336 no 1555 0.468532597312354 2145 676295 SGTC_983 1491-0821 12.2 µM 0.0784859913174608 0.469245998472896 no 1556 0.468720736578071 2262 46495113 SGTC_1846 st056244 14.8 µM 0.0777466521597658 0.469573996178829 no 1557 0.469014791665315 2200 5393182 SGTC_3072 9116419 49.47 µM 0.0777040525360102 0.46959289555056 no 1558 0.469031735199088 2193 17170162 SGTC_84 0443-0269 128.823 µM 0.0774111210554768 0.469722856789411 no 1559 0.469148247004332 2272 6150058 SGTC_2851 9015922 71.43 µM 0.0772882071011182 0.469777389444608 no 1560 0.469197136107543 2243 2996893 SGTC_1667 st014849 34.6 µM 0.0770043334007073 0.469903336516985 no 1561 0.469310048825448 2257 5348460 SGTC_1249 0481-0015 10.2 µM 0.0769966091312717 0.469906763608267 no 1562 0.469313121241308 2237 4227577 SGTC_1042 0350-0096 82 µM 0.0754849623914326 0.470577491161876 no 1563 0.469914430836422 2160 3122515 SGTC_533 1222-0222 6.71 µM 0.07440695099713 0.471055862978848 no 1564 0.470343289020787 2247 3982874 SGTC_250 brefeldin a 552.239 µM 0.0732288512214106 0.471578697150467 no 1565 0.470812004030192 2262 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.  SGTC_2135 5326629 150.42 µM 0.0731020011855283 0.471634995432648 no 1566 0.470862474602772 2207 5020077 SGTC_578 3460-0051 92 µM 0.0729511323851059 0.471701954403802 no 1567 0.470922502272249 2283 2876744 SGTC_1450 4112-4260 37.6 µM 0.0724771664079829 0.471912316372854 no 1568 0.471111088119184 2276 1633175 SGTC_2105 5350118 200 µM 0.0722458085666533 0.472015003578316 no 1569 0.47120314521403 2208 2133313 SGTC_2437 5741531 144.16 µM 0.0708160084808741 0.472649655348651 no 1570 0.471772095443395 2259 2262990 SGTC_2151 5563267 85.4165 µM 0.0701030643636953 0.472966139094556 no 1571 0.472055813847919 2170 5310824 SGTC_2106 5357045 167.29 µM 0.0699956131236268 0.473013839368292 no 1572 0.472098575647689 2250 668842 SGTC_737 1950-0117 57.9 µM 0.0697279475458114 0.473132664446253 no 1573 0.472205098494584 2296 5393513 SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM 0.069552776322122 0.473210429697571 no 1574 0.472274812448137 2260 279621 SGTC_10 0279-0212 42.575 µM 0.0690794561570057 0.47342055984271 no 1575 0.472463186785047 2281 39851 YBR002C RER2 SGTC_2421 5690543 90.72 µM 0.0680099173082926 0.473895407990037 no 1576 0.472888869847431 2202 3397993 SGTC_1505 k297-0037 20.6 µM 0.0678726999928871 0.473956331699864 no 1577 0.472943485437162 2206 4089396 SGTC_2061 5245884 80.95 µM 0.0668810514515493 0.474396636047536 no 1578 0.473338199004478 2269 573863 SGTC_766 1391-0721 126 µM 0.0663240751200937 0.474643954251677 no 1579 0.473559908123788 2283 1020919 YIL115C NUP159 SGTC_3285 9112818 20.8695 µM 0.0662875480183597 0.474660173985687 no 1580 0.473574448331168 2289 17017947 YPR165W RHO1 SGTC_830 4076-0286 57.8 µM 0.0661492535383215 0.474721583554634 no 1581 0.473629499018716 2239 6866659 SGTC_1160 4092-0570 10.5 µM 0.0658960876100118 0.474834003266354 no 1582 0.473730277724835 2246 4994975 SGTC_2655 perillic acid 100 µM 0.0650653489273016 0.47520291133839 no 1583 0.474060984749013 2221 5702197 An apoptosis inducer. SGTC_3221 9128209 49.47 µM 0.0613323363576934 0.476860896848103 no 1584 0.475547269289391 2251 16460723 SGTC_1240 0356-0016 42.1 µM 0.0611557443036237 0.476939338844248 no 1585 0.475617587326724 2246 4305613 SGTC_2618 avocadyne 43.43 µM 0.0609949475511605 0.47701076536212 no 1586 0.47568161641774 2237 3015189 SGTC_1162 k048-0130 20.1 µM 0.0598657974318593 0.477512358735139 no 1587 0.476131260355808 2232 6797406 SGTC_2202 7226349 200 µM 0.0595166968204658 0.477667444169108 no 1588 0.476270283455574 2287 844334 SGTC_2758 dehydroepiandrosterone 69.35 µM 0.0588514840675454 0.477962969489391 no 1589 0.476535200566695 2234 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem] SGTC_2998 9066762 71.4286 µM 0.0586970196942942 0.478031593084365 no 1590 0.476596716593257 2265 4945196 SGTC_231 b-estradiol 524 µM 0.058108055323246 0.478293257130689 no 1591 0.476831279008473 2279 450 A steroid. SGTC_2128 5255449 168.493 µM 0.0577688817528004 0.478443948816141 no 1592 0.476966362766045 2292 736008 SGTC_2910 7948405 25.97 µM 0.0574430467631027 0.478588717195842 no 1593 0.477096136616732 2282 2971328 SGTC_501 nsc-95397 161 µM 0.0556659474920827 0.47937833104376 no 1594 0.477803963692815 2273 262093 SGTC_586 0957-0265 8.15 µM 0.0542616187644146 0.48000237014088 no 1595 0.478363364134221 2313 6752309 YPR165W | YPR107C RHO1 | YTH1 SGTC_636 0kpi-0074 126 µM 0.0528975045792014 0.480608586117506 no 1596 0.478906786335921 2251 616434 SGTC_1984 st072354 53.1 µM 0.0517587899090596 0.48111466835438 no 1597 0.479360446199638 2235 5762938 SGTC_1819 st053448 58.6 µM 0.0512320503824279 0.481348779063492 no 1598 0.479570306429199 2267 2857616 SGTC_2361 9034121 116 µM 0.0509038356666746 0.481494658178356 no 1599 0.479701074527217 2255 6496917 SGTC_2585 alliin 100 µM 0.0505158008862107 0.481667128260439 no 1600 0.479855679096878 2268 87310 A garlic compound which reacts with lipids. SGTC_3226 9131256 49.47 µM 0.0501250851954992 0.481840793395383 no 1601 0.480011354882722 2310 17178073 SGTC_78 0336-0123 156.75 µM 0.04999871631693 0.481896962516931 no 1602 0.480061705637351 2162 6765896 SGTC_835 0312-0010 67.2 µM 0.0499500507813991 0.481918593732865 no 1603 0.480081096148637 2316 1626196 SGTC_2277 7947813 106.88 µM 0.0495016420548479 0.482117908245468 no 1604 0.48025976431766 2278 1246798 SGTC_1418 3966-3099 2.4 µM 0.049012715949049 0.482335237538968 no 1605 0.480454581128842 2304 740335 SGTC_3139 9095020 49.47 µM 0.0486464462802993 0.482498049077603 no 1606 0.480600527489169 2330 25236292 SGTC_117 lucigenin 22.078 µM 0.0477826368348228 0.482882034902295 no 1607 0.480944737273625 2197 65100 An acridine derivative; a dye stuff and potential carcinogen. SGTC_1376 2910-0861 41.3 µM 0.0476438712699122 0.482943721304155 no 1608 0.481000033745931 2324 1112859 SGTC_1458 k015-0034 6.33 µM 0.0472498043430612 0.483118900780744 no 1609 0.48115706684718 2228 3598957 SGTC_2308 7584454 197.62 µM 0.0463077985110116 0.483537675503003 no 1610 0.481532461833112 2308 893577 SGTC_2300 7976697 71.57 µM 0.0442127582580922 0.484469103492806 no 1611 0.482367406189741 2284 2236109 SGTC_1881 5652484 16 µM 0.0440945853331067 0.484521644230253 no 1612 0.482414504433393 2321 2255129 SGTC_1125 tnp00248 1.32998 µM 0.0435812110013917 0.484749898149204 no 1613 0.48261911445744 2317 24207736 SGTC_1149 3909-7961 23.3 µM 0.0432363257021502 0.484903242130895 no 1614 0.482756574214322 2195 735261 SGTC_2832 7992762 51.95 µM 0.0427171804893075 0.485134070303591 no 1615 0.48296349201009 2282 2985177 SGTC_2109 5483026 200 µM 0.0425452436850136 0.485210519877681 no 1616 0.48303202256808 2276 759335 SGTC_1051 3253-3903 78 µM 0.0425400794465108 0.4852128161009 no 1617 0.483034080937623 2333 5509239 SGTC_195 4234-0266 16.654 µM 0.0424717897608976 0.485243180422695 no 1618 0.483061299980351 2277 2303354 SGTC_2190 6049624 200 µM 0.0421940438646888 0.485366678221509 no 1619 0.483172005320563 2311 2265554 SGTC_369 0957-0393 4.5 µM 0.0420243255181605 0.485442143006398 no 1620 0.483239653142078 2291 6997992 SGTC_1556 plumbagin 1.48 µM 0.0410327274823483 0.485883064615791 no 1621 0.483634902533347 2332 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_2283 7944793 200 µM 0.0408374290403091 0.485969907604996 no 1622 0.483712750087899 2312 2970533 SGTC_329 k048-0121 21.3 µM 0.0407402850377448 0.486013104693119 no 1623 0.48375147271238 2246 6832902 SGTC_3018 9082602 49.47 µM 0.0398040529690079 0.486429427966963 no 1624 0.484124672495921 2293 17332089 SGTC_1079 idarubicin 2.36 µM 0.0396559334973407 0.486495295036717 no 1625 0.484183716997215 2344 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_3199 9111318 49.47 µM 0.0395444398785035 0.486544875243142 no 1626 0.48422816165358 2331 8548020 SGTC_1454 4239-0054 42.6 µM 0.0382285976871386 0.487130033897508 no 1627 0.484752709949441 2319 1340767 SGTC_296 1222-0039 74.9 µM 0.0371841999137919 0.487594500256325 no 1628 0.485169068271239 2312 5984176 SGTC_612 0302-0167 22.4 µM 0.0368365980139371 0.487749090129204 no 1629 0.485307646422561 2308 235821 SGTC_1897 st060201 15 µM 0.0362821324680527 0.487995682795377 no 1630 0.485528698392022 2274 611878 SGTC_2691 st077356 60.2 µM 0.0360552623986831 0.488096582179046 no 1631 0.485619147273836 2325 2839272 SGTC_2251 lansoprazole 556 µM 0.0358100484802912 0.488205640758852 no 1632 0.485716910339333 2255 3883 Gastric proton pump inhibitor. YBR192W RIM2 SGTC_2501 sodium tetradecyl sulfate 13.37 µM 0.0356385378777459 0.488281920406861 no 1633 0.485785289522601 2353 23665772 A membrane-active detergent. SGTC_987 1497-1013 404 µM 0.0345822426928679 0.488751718928109 no 1634 0.486206430654197 2329 1676435 SGTC_2345 9052315 157.45 µM 0.0343327202645223 0.488862698985871 no 1635 0.486305916622238 2305 6469265 SGTC_2464 5717415 7.67 µM 0.0316260826610532 0.490066583436519 no 1636 0.487385121417484 2354 5285744 SGTC_417 st075190 100 µM 0.0316006935941858 0.490077876676824 no 1637 0.487395245129602 2354 222757 SGTC_12 0849-0099 9.267 µM 0.0307579976198955 0.490452718390588 no 1638 0.487731268800656 2365 6071388 SGTC_266 formosanin C 406 nM 0.0304783735315108 0.490577100563402 no 1639 0.487842770394635 2341 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1 SGTC_125 0133-0007 11.75 µM 0.0299647242981682 0.49080558400072 no 1640 0.488047593230848 2347 26541 SGTC_990 3985-0011 41.3 µM 0.028775455253042 0.491334610707318 no 1641 0.488521838321246 2324 5399565 YGL099W LSG1 SGTC_2522 biochanin a 4.94 µM 0.0286353270075282 0.491396945466459 no 1642 0.488577718375703 2342 5280373 A possible chelator. SGTC_630 4356-0227 183 µM 0.0280940263389524 0.491637740042079 no 1643 0.488793579242748 2360 779312 SGTC_3093 9117344 49.47 µM 0.0275304620586468 0.491888441697597 no 1644 0.489018321920519 2317 24824913 SGTC_2719 novobiocin 32.65 µM 0.0269650781456539 0.49213995603665 no 1645 0.489243793749769 2352 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication. SGTC_1297 1068-0111 14.1 µM 0.0267294486762313 0.492244778111975 no 1646 0.489337762436144 2334 767057 SGTC_2546 rhodinyl acetate 100 µM 0.0261357500757036 0.492508893102677 no 1647 0.489574531178719 2363 6708682 SGTC_2274 7947094 46.08 µM 0.0259966069772341 0.49257079330371 no 1648 0.489630022388846 2358 2971028 SGTC_402 epigallocatechin gallate 10 µM 0.0254621521802969 0.492808556364517 no 1649 0.489843168438648 2308 65064 An antioxidant. SGTC_171 k064-0041 9.68 µM 0.0219106245211012 0.49438858636902 no 1650 0.491259624834075 2336 53325 SGTC_1732 st034308 51.822 µM 0.0209654005274838 0.494809120494999 no 1651 0.491636627992457 2364 830119 SGTC_2381 9035592 200 µM 0.0204649765184506 0.495031763604249 no 1652 0.491836225455577 2295 4749657 SGTC_1202 1988-0068 29.6 µM 0.019806790527447 0.495324598772921 no 1653 0.492098750444745 2354 2850480 SGTC_617 3770-0098 35 µM 0.0192979306664916 0.49555099861613 no 1654 0.492301717355584 2347 5962639 SGTC_530 4358-1714 28 µM 0.0191698018536833 0.495608005390945 no 1655 0.492352823902223 2306 1564641 SGTC_2649 anisomycin 9.56 µM 0.0186985257625944 0.495817685221206 no 1656 0.492540802160597 2347 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_295 k015-0027 31 µM 0.0185756107799262 0.495872372662021 no 1657 0.4925898296287 2344 3887424 SGTC_1873 rapamycin 2 nM 0.0185332184968996 0.495891233891435 no 1658 0.492606738791883 2376 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1 SGTC_944 3370-0224 231 µM 0.0180766589284249 0.496094367538795 no 1659 0.492788849193195 2367 4580514 SGTC_3149 9097855 49.47 µM 0.0175234003296406 0.496340526117403 no 1660 0.4930095324739 2365 25236625 YMR079W SEC14 SGTC_380 3970-0968 6 µM 0.0168589842777436 0.496636143258215 no 1661 0.493274556958729 2366 2891601 SGTC_372 0155-0182 15.9 µM 0.0167521989955488 0.49668365517037 no 1662 0.493317152107247 2343 771486 SGTC_2129 girgensonine 121.053 µM 0.0164814987068436 0.496804097898194 no 1663 0.493425130988823 2355 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_1978 st071761 42 µM 0.0157853753103164 0.497113825516756 no 1664 0.493702807898162 2330 5147680 SGTC_3119 9125183 49.47 µM 0.0157097155661699 0.497147489070927 no 1665 0.493732988026675 2380 22695334 SGTC_1710 st031758 61.5 µM 0.0153583160878858 0.497303838730326 no 1666 0.493873159222082 2382 5394341 SGTC_1544 7-methoxy-4-methylcoumarin 105 µM 0.0149294533403651 0.497494655009196 no 1667 0.494044231085546 2382 390807 SGTC_786 4544-0069 423 µM 0.0144605331208627 0.497703294935491 no 1668 0.494231282988179 2340 748821 YLR208W SEC13 SGTC_67 0335-0847 266 µM 0.0139929427132957 0.497911343804911 no 1669 0.494417805692909 2363 4552207 YOR254C SEC63 SGTC_2931 9014674 55.67 µM 0.0139040971626066 0.497950874656937 no 1670 0.494453246491622 2376 2996810 SGTC_527 4476-4215 268 µM 0.0136555929363735 0.498061443988791 no 1671 0.494552375922071 2274 4418754 SGTC_1313 1220-0047 237 µM 0.0132809885787725 0.498228120521499 no 1672 0.494701807884157 2365 3528706 SGTC_1440 4100-1550 40 µM 0.013000301083127 0.498353009872432 no 1673 0.494813776325804 2374 742806 SGTC_424 splitomicin 100 mM 0.0128720456727318 0.498410076006456 no 1674 0.494864938550626 2320 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_1990 st072050 59.8 µM 0.0119714334035415 0.498810796485625 no 1675 0.495224203132651 2382 17233948 SGTC_1528 arabinosylhypoxanthine 74.6 µM 0.0114588025772696 0.499038888177586 no 1676 0.495428699207839 2383 804 An inhibitor of viral and cellular DNA polymerases. SGTC_3132 9126706 49.47 µM 0.0114013225228495 0.499064463568183 no 1677 0.495451628933933 2356 850858 SGTC_119 0121-0043 24.815 µM 0.00945293407582698 0.499931388410169 no 1678 0.496228881086639 2385 1092378 SGTC_647 0140-0236 81 µM 0.00914452926153785 0.499931388410169 no 1679 0.496351911486938 2381 990837 SGTC_1658 st012944 20 µM 0.00895817700353356 0.499848471907889 no 1680 0.496426252236277 2379 24207260 SGTC_2988 9073640 71.4286 µM 0.00826400616675452 0.499539604162919 no 1681 0.496703176060064 2384 9102229 SGTC_868 0527-0199 213 µM 0.00813026037745605 0.499480094687564 no 1682 0.496756531117628 2361 2849450 SGTC_314 1671-0008 2.74 µM 0.0078523128078413 0.499356423437962 no 1683 0.496867412613986 2386 3913060 SGTC_2539 epi(13)torulosol 80 µM 0.00764764709418535 0.499265358587891 no 1684 0.496949059968373 2392 6708597 SGTC_1136 pergolide 1.05886 µM 0.00753311885039033 0.499214399910898 no 1685 0.496994748810923 2381 47811 A dopamine receptor agonist. SGTC_2301 7769476 200 µM 0.00670715062056024 0.498846890574106 no 1686 0.497324254098245 2384 977820 SGTC_2741 miltefosine 3.04 µM 0.00628541924717374 0.498659244226167 no 1687 0.497492497022707 2386 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis. SGTC_1146 3579-1023 7 µM 0.00562371867085045 0.498364825917269 no 1688 0.497756472674833 2393 X1146 SGTC_444 curcumin 90.4 µM 0.00546444637502611 0.498293959126934 no 1689 0.497820012151157 2388 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. SGTC_3066 9117245 49.47 µM 0.00528506483273185 0.498214144970948 no 1690 0.497891573998959 2392 17176980 SGTC_3263 9137018 49.47 µM 0.00413479796794597 0.497702346217884 no 1691 0.498350458969914 2389 43844957 SGTC_1102 cgs 12066b 26.1 µM 0.00142045302852733 0.496494644410454 no 1692 0.49943332142016 2397 6438352 A 5-HT1B full agonist. SGTC_3181 9108277 49.47 µM 0.00117419866426555 0.496385079125412 no 1693 0.499531562614876 2403 17097298 SGTC_340 k038-0059 454 µM 0 0.495862649997492 no 1694 0.5 2405 23733424 SGTC_719 2810-4230 27.3 µM 0 0.495862649997492 no 1695 0.5 2405 721079 SGTC_1729 st035615 45.989 µM -0.000625372516529717 0.495584409615384 no 1696 0.499750512478417 2410 17385451 SGTC_120 rhodamine 6G 52.259 µM -0.00160419122420505 0.495148918519531 no 1697 0.499360020569306 2408 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase SGTC_2195 6536160 144.242 µM -0.00162725625024323 0.495138656611847 no 1698 0.499350818967232 2410 3834386 SGTC_475 α-linolenic acid 10 µM -0.00342679330914523 0.494338031369688 no 1699 0.498632909938389 2412 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_229 benomyl 22.8748 µM -0.00395117731939007 0.494104733806326 no 1700 0.498423712411382 2417 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C SGTC_503 tyrphostin 8 294 µM -0.00424947825008047 0.493972021119084 no 1701 0.498304708558679 2409 92970 A tyrosine kinase inhibitor. YOR207C RET1 SGTC_1966 st070145 16.1 µM -0.0049079576116734 0.493679069117295 no 1702 0.498042016058957 2416 3748532 SGTC_1634 st006576 41 µM -0.0049155215947989 0.493675703983495 no 1703 0.49803899850268 2422 3915356 SGTC_1743 st037606 46.3785 µM -0.00510285711660311 0.493592360592169 no 1704 0.497964263380152 2420 590142 YLR208W | YDL195W SEC13 | SEC31 SGTC_653 0203-0016 55.2 µM -0.00556012805023815 0.493388927262614 no 1705 0.497781841265392 2422 295302 SGTC_1659 st012954 42.1 µM -0.00592625820789399 0.493226042403942 no 1706 0.497635778875089 2423 24207262 SGTC_3160 9100216 49.47 µM -0.0063882320706668 0.493020519983923 no 1707 0.497451481463971 2418 17191039 SGTC_1731 st035964 63 µM -0.00709367447788186 0.492706687140809 no 1708 0.497170057061279 2435 6739575 SGTC_981 1488-1094 54.9 µM -0.00710537113141049 0.492701483643636 no 1709 0.497165390889244 2418 3449522 SGTC_2450 5739737 12.93 µM -0.00746420990775418 0.492541847432747 no 1710 0.497022238728743 2421 2262825 SGTC_3334 9142812 21.919 µM -0.00767640982782023 0.492447446848597 no 1711 0.496937585634642 2450 45283678 SGTC_4 0960-0234 25.671 µM -0.00785795474967116 0.492366683974295 no 1712 0.496865161874286 2372 6821112 SGTC_3106 9121286 49.47 µM -0.00901398832708148 0.491852413259706 no 1713 0.496403987638539 2486 15943471 SGTC_2409 alverine citrate 63.97 µM -0.0094113523173912 0.491675645818332 no 1714 0.496245469070278 2486 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM -0.00979915391053445 0.491503133786995 no 1715 0.496090765756032 2404 91467 include heat shock SGTC_2847 9005661 71.43 µM -0.0115806447857438 0.490710665412318 no 1716 0.495380094424504 2425 2991449 SGTC_2069 5228469 200 µM -0.0115940276183571 0.490704712403218 no 1717 0.495374755805153 2435 2835210 SGTC_770 0389-1121 67.2 µM -0.0120588783679047 0.490497936789896 no 1718 0.495189320157183 2439 6753108 SGTC_1077 5-fluorocytosine 377 nM -0.0121469763288044 0.490458749207861 no 1719 0.495154176729788 2433 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_70 0141-0289 43.283 µM -0.0131020572328911 0.490033917768993 no 1720 0.494773184952567 2486 352408 SGTC_942 3253-1115 227 µM -0.0131329880916284 0.490020159538529 no 1721 0.494760846386839 2438 46497897 SGTC_2424 5537928 59.2 µM -0.0132573071510388 0.489964861799303 no 1722 0.494711254575263 2426 5382802 SGTC_173 1273-0061 2.693 µM -0.013575401214207 0.489823372850203 no 1723 0.494584364825355 2446 2847414 YPL266W DIM1 SGTC_1224 0823-0416 294 µM -0.0135999480869617 0.489812454399424 no 1724 0.494574572943916 2440 3598164 SGTC_3252 9135871 49.47 µM -0.0151299833229247 0.489131910013536 no 1725 0.493964240232323 2456 17682838 SGTC_2374 9071832 200 µM -0.0181997235668662 0.487766617648408 no 1726 0.492739761581158 2438 17381698 SGTC_2095 5432005 200 µM -0.0184871333074078 0.487638796880791 no 1727 0.492625120973088 2449 783734 SGTC_2715 st079500 56.4 µM -0.0190615626920336 0.487383332652581 no 1728 0.492395997191497 2432 28246688 SGTC_623 k072-0108 16.9 µM -0.0202997789122104 0.486832682273217 no 1729 0.491902116076987 2482 5382803 SGTC_2720 fluspirilene 36.88 µM -0.020647881928907 0.48667788094402 no 1730 0.491763272169579 2459 3396 An atypical antipsychotic. SGTC_1487 3970-0795 2.82 µM -0.0218760906325561 0.486131713016619 no 1731 0.491273398560921 2463 3765103 SGTC_3022 9087993 49.47 µM -0.0227905680661296 0.485725074012362 no 1732 0.490908665832502 2444 17173644 SGTC_1293 1000-1278 195 µM -0.022957813371961 0.485650706941851 no 1733 0.490841962061828 2466 678847 SGTC_1000 4048-0884 8.67 µM -0.0229770156774722 0.485642168502656 no 1734 0.490834303470507 2472 13040088 SGTC_163 TUB2.036 7.546 µM -0.0232773481810687 0.485508624417435 no 1735 0.490714520175416 2440 15992207 YJR013W GPI14 SGTC_2243 6634756 200 µM -0.0235358660529722 0.485393674681503 no 1736 0.490611414714386 2451 885676 SGTC_560 2332-1943 155 µM -0.0242615220387525 0.485071018925082 no 1737 0.490322002527317 2444 21177716 SGTC_1718 roemerine 11.9335 µM -0.0243931783777698 0.485012480277555 no 1738 0.490269494787102 2452 235224 An aporphine alkaloid with mutagenic activity. SGTC_2161 5662504 8.5105 µM -0.0246810793754637 0.484884471351037 no 1739 0.490154673477424 2473 2859334 SGTC_2429 5902844 64.44 µM -0.0256030722194067 0.484474537802445 no 1740 0.489786967798923 2479 1927790 YGL093W | YPR107C SPC105 | YTH1 SGTC_225 nsc-122657 1.016 µM -0.0256162297092533 0.484468687878556 no 1741 0.489781720440953 2514 275685 SGTC_742 0kpi-0133 140 µM -0.0261901769924377 0.484213509654846 no 1742 0.489552825410522 2465 2728852 SGTC_753 1322-0200 289 µM -0.0264019875470195 0.484119339844415 no 1743 0.489468354435233 2496 5403907 SGTC_979 1426-2828 121 µM -0.0271041267445973 0.483807178973546 no 1744 0.489188341652498 2515 747872 SGTC_1062 mesoridazine 14.2 µM -0.0277394514851963 0.483524731385965 no 1745 0.48893497903244 2455 4078 A neuroleptic. SGTC_2702 st077768 96.8 µM -0.0281483575303983 0.483342947573554 no 1746 0.488771912801958 2494 6484119 SGTC_608 k048-0125 159 µM -0.0286601627716112 0.483115423641959 no 1747 0.48856781440424 2451 6817652 YLR060W | YFL022C FRS1 | FRS2 SGTC_2359 9039622 200 µM -0.0293910913889457 0.48279049757489 no 1748 0.48827633888935 2474 6463596 SGTC_1432 4049-0298 68.4 µM -0.03015904139253 0.48244912638524 no 1749 0.487970106946964 2474 741646 SGTC_2334 9017922 200 µM -0.0320495593654831 0.481608803624998 no 1750 0.487216264259037 2498 3163164 SGTC_3177 9107506 49.47 µM -0.0321078909976354 0.481582876879795 no 1751 0.487193005275035 2476 8897194 SGTC_1071 trifluoperazine 6.31 µM -0.0326398452149924 0.481346442024706 no 1752 0.486980897429774 2520 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. SGTC_2184 6075246 200 µM -0.0330138887892236 0.481180196795181 no 1753 0.486831756013455 2487 2267320 SGTC_736 0958-0254 92.6 µM -0.0330573163826739 0.481160895431311 no 1754 0.486814440361599 2498 6812352 SGTC_1383 3049-0032 20.7 µM -0.0354811779986208 0.480083683142277 no 1755 0.485848027352914 2482 712864 SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM -0.0355566744094865 0.480050133331096 no 1756 0.485817927635411 2514 616764 SGTC_109 0132-0036 33.701 µM -0.03624518456524 0.479744173208368 no 1757 0.485543428783818 2459 67274 A color developer. SGTC_2568 diosmetin 100 µM -0.0371960758029908 0.479321635848268 no 1758 0.485164333752224 2467 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.  SGTC_145 3737-0113 38.366 µM -0.0375853301590054 0.479148673733192 no 1759 0.485009152247571 2505 6849351 SGTC_511 blebbistatin 171 µM -0.0380139236126631 0.478958236142097 no 1760 0.4848382903075 2549 3476986 A myosin inhibitor. SGTC_3031 9088762 49.47 µM -0.0383874604649345 0.478792265851796 no 1761 0.484689379356699 2456 205253 SGTC_745 0469-0705 296 µM -0.0385682054972391 0.47871195834582 no 1762 0.484617325880344 2493 3486736 SGTC_697 0508-1955 564 µM -0.0390645758980455 0.478491418599329 no 1763 0.48441945186851 2469 6243113 SGTC_2498 4'-Methoxychalcone 54.63 µM -0.0397760269376301 0.478175328996055 no 1764 0.48413584441733 2479 641818 YHR062C RPP1 SGTC_2583 asiatic acid 100 µM -0.040050415080441 0.478053425123 no 1765 0.484026466544015 2526 5320556 A kinase inhibitor; arrests cells at G2/M. SGTC_759 3486-0358 89.3 µM -0.040909304104746 0.477671855273552 no 1766 0.483684100027648 2472 875103 SGTC_2616 abietic acid 100 µM -0.0412127563914068 0.4775370485024 no 1767 0.483563142091906 2483 6708678 Abietic acid is an inhibitor of 5α-reductase. SGTC_2043 5101342 149 µM -0.0418138612577822 0.477270019046817 no 1768 0.483323542495891 2503 678451 SGTC_1329 1447-1697 50.6 µM -0.0419328434765937 0.477217164655048 no 1769 0.483276117053805 2568 2840515 SGTC_3001 9076041 71.4286 µM -0.0425670578025522 0.476935440162096 no 1770 0.483023327871011 2497 16004211 SGTC_1504 k297-0033 30 µM -0.0443109899174621 0.476160827522935 no 1771 0.482328255796382 2471 4388117 SGTC_603 3794-0023 45.9 µM -0.0443525253536188 0.476142379569343 no 1772 0.482311701829555 2492 3802260 SGTC_1457 k015-0032 57.3 µM -0.0448609789330423 0.475916554195585 no 1773 0.482109059906235 2481 4302660 SGTC_1244 0416-0015 52.5 µM -0.0458115714347113 0.475494377350544 no 1774 0.481730217911982 2506 96201 SGTC_1771 st048882 4.1505 µM -0.0459671702055364 0.475425275480574 no 1775 0.481668208308945 2483 4580403 SGTC_2165 5727197 32.143 µM -0.0466661158258358 0.475114880830286 no 1776 0.481389668281667 2758 1361712 SGTC_406 estrone 100 µM -0.0468456954450588 0.475035133776641 no 1777 0.481318104644883 2496 5870 A steroid. SGTC_1391 3442-0225 151 µM -0.0469905279220994 0.474970817833932 no 1778 0.481260388406882 2503 5227075 SGTC_2072 5231554 129 µM -0.0479125365634395 0.474561395643625 no 1779 0.480892974066754 2515 789545 SGTC_1193 1488-0126 41.5 µM -0.0480172461017512 0.474514900580718 no 1780 0.480851249029349 2525 1384710 SGTC_2314 7727897 200 µM -0.0484510013397613 0.474322300273764 no 1781 0.480678406905157 2506 900724 SGTC_3050 9093513 49.47 µM -0.0489548393862161 0.474098588639444 no 1782 0.480477642852923 2506 25236664 SGTC_1129 3453-1384 223 µM -0.0491383621336906 0.474017103818118 no 1783 0.480404515878553 2658 1084452 SGTC_3114 9122766 49.47 µM -0.0517708717071185 0.47284838051337 no 1784 0.479355632712995 2553 17176985 SGTC_2959 9079155 11 µM -0.0527681457912434 0.47240569334272 no 1785 0.478958321050913 2587 16189457 SGTC_728 3030-5151 22.5 µM -0.0543586382450798 0.471699748949369 no 1786 0.478324716001502 2509 3125388 SGTC_1636 st007707 68.9 µM -0.0545653264201051 0.471608016321975 no 1787 0.478242381546784 2533 403051 SGTC_1175 0741-0056 27.6 µM -0.0546066548519303 0.471589674061607 no 1788 0.478225918433223 2538 765927 SGTC_2223 6903751 107.57 µM -0.0546401523931075 0.471574807327797 no 1789 0.478212574769468 2579 5598863 SGTC_2623 humulene 100 µM -0.0570082144682338 0.470523925850285 no 1790 0.477269325792786 2546 6187145 An anti-inflammatory. SGTC_1716 st033144 30.6155 µM -0.0576393992259567 0.470243857580672 no 1791 0.477017932890758 2522 674617 SGTC_2214 7179297 48.276 µM -0.0582160198334905 0.469988013288449 no 1792 0.476788280190803 2493 769744 SGTC_1215 3852-0577 11.2 µM -0.0582170083852716 0.469987574682526 no 1793 0.476787886483436 2617 2884876 SGTC_2863 9028737 58.44 µM -0.0585732282500717 0.469829527529155 no 1794 0.476646017411369 2604 6460917 SGTC_1632 st005650 90 µM -0.0588498438385085 0.469706802371975 no 1795 0.476535853791238 2573 2759605 SGTC_2801 7907800 81.82 µM -0.0588929970207599 0.469687656996231 no 1796 0.476518667969815 2561 6620925 SGTC_1318 1280-3875 124 µM -0.0592129339747882 0.469545715697218 no 1797 0.476391253948576 2562 373245 SGTC_2544 sphondin 68.51 µM -0.0602768435007424 0.469073735947968 no 1798 0.475967572306849 2604 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31 SGTC_2549 cedrol 20.94 µM -0.0608788108191044 0.468806705771345 no 1799 0.475727862328136 2531 6708665 A sedative which affects the nervous system. SGTC_2442 5158906 48.48 µM -0.0609757792718064 0.468763692281683 no 1800 0.475689249247545 2598 1893835 SGTC_1930 st074634 34.3 µM -0.062137150297598 0.468248557122039 no 1801 0.475226806242695 2516 684253 YOR116C RPO31 SGTC_2497 7-hydroxyflavone 100 µM -0.06218222321818 0.468228565743272 no 1802 0.475208859454128 2593 5281894 SGTC_2348 9022543 33.42 µM -0.0631677536666185 0.467791469465381 no 1803 0.474816461163318 2577 3162678 YDL140C RPO21 SGTC_2338 7999974 200 µM -0.0647225788992513 0.467101962295967 no 1804 0.474197442574867 2612 315925 SGTC_200 k038-0079 37.545 µM -0.0651329775954043 0.466919982117028 no 1805 0.474034061922566 2556 3436683 SGTC_1840 st055363 71 µM -0.0653429866615973 0.46682686196055 no 1806 0.473950458524169 2569 676033 SGTC_2844 9010103 25.97 µM -0.0657497182632638 0.466646518198633 no 1807 0.473788544284498 2655 2480525 SGTC_1907 st060210 83.7 µM -0.0659192380820181 0.466571355560004 no 1808 0.473721062060087 2520 688793 SGTC_2543 pimpinellin 60.67 µM -0.0659876653560623 0.466541016232824 no 1809 0.473693822835193 2522 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo. SGTC_1864 st057645 30.4 µM -0.0663502449316499 0.46638025872451 no 1810 0.473549490826002 2520 688666 SGTC_2097 5376186 200 µM -0.0667295111698842 0.466212108692575 no 1811 0.473398520074837 2534 742755 SGTC_601 0986-0029 62.9 µM -0.06835344514682 0.465492196090216 no 1812 0.472752140248749 2537 24747981 SGTC_2503 beta-caryophyllene alcohol 24.72 µM -0.0684578523008985 0.465445914779515 no 1813 0.472710585159501 2660 61125 An anti-inflammatory. SGTC_3188 9110789 49.47 µM -0.0684853503710946 0.465433725589741 no 1814 0.472699640702544 2564 849217 SGTC_2570 licareol 100 µM -0.0685945104835159 0.465385338029575 no 1815 0.472656194287921 2619 443158 SGTC_782 0083-0095 30.5 µM -0.0688839716967274 0.465257030620703 no 1816 0.472540988472142 2505 3591729 An indicator and reagent. SGTC_908 3448-7491 47.7 µM -0.0701106209745314 0.464713342781896 no 1817 0.472052806595725 2525 1203031 SGTC_3040 9091894 49.47 µM -0.0703056377419743 0.464626911530217 no 1818 0.47197519767206 2567 25236966 SGTC_888 0916-0002 6.97 µM -0.0706473410895741 0.4644754729481 no 1819 0.47183921588608 2703 2802138 YIL048W NEO1 SGTC_948 3448-0295 75.3 µM -0.0708802781116277 0.464372241167875 no 1820 0.471746519838815 2543 678569 SGTC_146 3448-8650 53.125 µM -0.0713796407266706 0.464150944412641 no 1821 0.471547806309541 2581 2891488 YIL048W NEO1 SGTC_1170 0310-0127 64.8 µM -0.0719084313744359 0.463916618467454 no 1822 0.471337390078027 2603 774975 SGTC_1585 2',4'-dihydroxychalcone 10.4 µM -0.0724048483416602 0.463696649840585 no 1823 0.471139863252704 2551 5357218 A potent inhibitor of glutathione S-transferases. SGTC_1867 st057372 64 µM -0.0726891452370584 0.463570679289587 no 1824 0.471026743272346 2526 688837 SGTC_2053 5265679 138 µM -0.0731923285627307 0.463347730202708 no 1825 0.470826535467972 2543 764595 SGTC_3164 9100705 49.47 µM -0.0734273383620636 0.463243606645208 no 1826 0.470733031720891 2632 17174235 SGTC_2179 6298986 200 µM -0.0739787739605417 0.462999297215832 no 1827 0.470513637448739 2577 738374 SGTC_1576 erythromycin ethylsuccinate 23.2 µM -0.0742530985484465 0.462877764945388 no 1828 0.47040449794548 2535 3256 An antibiotic and ribosome inhibitor. SGTC_3329 9141233 27.5565 µM -0.0750355269907949 0.462531149742315 no 1829 0.470093222553388 2630 4909101 YNL103W MET4 SGTC_699 0375-0592 111 µM -0.0751601546644186 0.462475942397843 no 1830 0.470043643308084 2524 762578 SGTC_181 1447-1644 8.07 µM -0.0759261060055129 0.462136658552452 no 1831 0.469738943607124 2535 534600 SGTC_2857 9024691 58.44 µM -0.0761875584535403 0.462020852539769 no 1832 0.469634940417622 2618 16478292 SGTC_2744 captopril 92.04 µM -0.0774974800272844 0.461440693239948 no 1833 0.469113897946775 2553 44093 angiotensin-converting enzyme (ACE) inhibitor  SGTC_247 mechlorethamine 29.705 µM -0.0780111517066107 0.46121321232723 no 1834 0.46890959112459 2527 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links. SGTC_1327 1436-0082 2.18 µM -0.0798706115393336 0.460389852094089 no 1835 0.468170081864443 2605 15992205 SGTC_671 0560-0003 407 µM -0.0810881229715104 0.45985083542012 no 1836 0.467685935539182 2646 3238678 SGTC_1755 st041960 45.185 µM -0.0812216569815301 0.459791721713864 no 1837 0.467632838317204 2636 2257073 SGTC_2921 7974240 10.71 µM -0.0815764656155515 0.459634657036111 no 1838 0.467491758311891 2633 2979074 YDR527W RBA50 SGTC_1814 st052110 31.539 µM -0.0817086773523873 0.459576131902536 no 1839 0.467439188953194 2572 674163 SGTC_2771 fluoxetine 41.05 µM -0.0821118580726504 0.459397664466153 no 1840 0.467278881795114 2640 3386 A selective serotonin reuptake inhibitor. SGTC_2567 aureobasidin a 60 nM -0.0823834832341221 0.459277434542172 no 1841 0.467170884934629 2765 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1 SGTC_2626 ethyl orsellinate 100 µM -0.082466715478474 0.459240594052115 no 1842 0.467137792677115 2565 75653 A natural product. SGTC_2600 tangeritin 87.95 µM -0.0826832745164148 0.459144741722622 no 1843 0.467051692165562 2574 68077 A bioactive flavone. SGTC_3340 9146634 11.102 µM -0.083332027540298 0.458857607987187 no 1844 0.466793767277788 2592 4907387 SGTC_459 nigericin 15.3 µM -0.0838864304563854 0.458612249978708 no 1845 0.46657336422898 2635 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification. SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM -0.0847166770274776 0.458244843393721 no 1846 0.466243318640254 2668 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W SGTC_2402 5553605 200 µM -0.0848880919318899 0.458168992090265 no 1847 0.46617517943814 2639 6758546 SGTC_2439 5492030 7.2 µM -0.0849289904264186 0.458150894681731 no 1848 0.466158922008867 2611 5722370 SGTC_1981 st071826 47 µM -0.0851686471522971 0.458044849352576 no 1849 0.46606365796891 2625 11838600 SGTC_2397 5161689 200 µM -0.0852800600542755 0.457995551448557 no 1850 0.466019371773674 2635 2259942 SGTC_739 1486-1183 203 µM -0.0863762583816036 0.457510540942875 no 1851 0.465583659724554 2554 4346692 SGTC_694 1315-0438 43.2 µM -0.0866932185865766 0.457370314367351 no 1852 0.465457683453809 2603 6793154 SGTC_2354 9060492 162 µM -0.0871095209402531 0.45718614583111 no 1853 0.465292228769984 2637 6471895 SGTC_2376 9072922 81.32 µM -0.087360642987739 0.457075056067378 no 1854 0.465192426038717 2691 17087968 SGTC_1007 4101-0031 70 µM -0.0874390560891392 0.457040368868356 no 1855 0.465161262987948 2557 1146276 SGTC_2794 7785382 27.27 µM -0.0888708630644628 0.456407045622838 no 1856 0.464592269904596 2542 2205081 SGTC_2682 pyrogallin 40.03 µM -0.0893145193559452 0.456210827989034 no 1857 0.464415977703969 2577 822798 An ATP competetive kinase inhibitor. SGTC_1357 1503-1303 39.5 µM -0.0906051123553141 0.455640093170786 no 1858 0.463903184786058 2571 292895 SGTC_971 1315-0384 26.7 µM -0.0907444323561376 0.455578487584892 no 1859 0.463847832167882 2606 6769120 SGTC_20 0481-0013 4.944 µM -0.0908768741805182 0.455519924434057 no 1860 0.463795212936611 2548 182045 SGTC_2099 5377090 177.372 µM -0.0911868679299869 0.455382855120304 no 1861 0.463672054676448 2644 2243829 SGTC_2747 doxorubicin 7.63 µM -0.0913075281796858 0.455329504455028 no 1862 0.463624118178142 2555 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_2246 7293507 91.5585 µM -0.0913827831968835 0.455296230398064 no 1863 0.463594220761613 2741 887656 SGTC_2030 5175110 200 µM -0.091456711165286 0.455263543401983 no 1864 0.463564850757047 2668 2831986 SGTC_108 0509-0257 621.132 µM -0.0928321504411249 0.454655453143128 no 1865 0.463018454464503 2603 536624 SGTC_218 alverine citrate 93.75 µM -0.093350826475023 0.454426170753727 no 1866 0.462812427322132 2670 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_755 1995-0008 37.3 µM -0.0948697437430276 0.453754816171109 no 1867 0.462209144546388 2567 689533 SGTC_2467 5474540 200 µM -0.0954193687878005 0.453511916834382 no 1868 0.461990866101044 2574 5413519 SGTC_1384 3089-0840 101 µM -0.0961412295843987 0.453192926674201 no 1869 0.461704203238518 2566 1069836 SGTC_886 0866-0150 153 µM -0.0962002445556835 0.45316684930133 no 1870 0.461680768294943 2673 271463 SGTC_818 4072-2707 53.5 µM -0.0965171454086866 0.453026821482551 no 1871 0.461554928714839 2584 882871 SGTC_871 0574-0004 149 µM -0.0976612240924044 0.452521340358006 no 1872 0.461100653503425 2593 9551173 SGTC_353 1988-1175 58.3 µM -0.0983009933849364 0.452238708584937 no 1873 0.460846644698363 2525 2788357 SGTC_3232 9132874 49.47 µM -0.0998665632824023 0.451547186945852 no 1874 0.460225131121187 2592 3784940 SGTC_2121 5257820 149.641 µM -0.103398718068544 0.449987556073377 no 1875 0.458823264763823 2625 791256 SGTC_2046 4110841 106 µM -0.104653026240166 0.449433898021149 no 1876 0.458325568413472 2624 44119630 YMR134W ERG29 SGTC_2955 9076254 12.21 µM -0.104941685469329 0.449306496252355 no 1877 0.458211040672257 2608 16459619 SGTC_1492 4158-0558 28.5 µM -0.105728450967793 0.448959278370447 no 1878 0.457898903127859 2703 3967268 SGTC_1060 3448-7350 82 µM -0.106343230746574 0.448687988969861 no 1879 0.457655016428186 2637 570178 SGTC_2754 granisetron 64.02 µM -0.106843622329635 0.448467194381352 no 1880 0.457456519954489 2685 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients. SGTC_870 0573-2213 57.6 µM -0.107079037671828 0.448363324382751 no 1881 0.457363138527669 2579 3916321 SGTC_2332 7982454 138.89 µM -0.107380469572659 0.448230331715498 no 1882 0.457243573967758 2574 2981748 SGTC_2582 agaric acid 100 µM -0.107813156790786 0.448039438978724 no 1883 0.457071953058411 2626 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase. SGTC_1350 1495-0454 146 µM -0.108492158904459 0.447739901428694 no 1884 0.45680265004499 2708 1069057 SGTC_2994 9053520 71.4286 µM -0.109339703836634 0.44736605409691 no 1885 0.45646652812464 2684 4647384 SGTC_3214 9129694 49.47 µM -0.109823030847914 0.447152882167838 no 1886 0.456274862774035 2658 17158655 SGTC_2351 9026858 72.31 µM -0.110407877245103 0.446894955416805 no 1887 0.456042953093007 2601 1409300 SGTC_812 4251-0442 148 µM -0.112676133591339 0.445894831024631 no 1888 0.455143661682556 2587 5723007 SGTC_3155 9099265 49.47 µM -0.112764421816307 0.445855909711027 no 1889 0.455108662829815 2703 25236499 SGTC_1626 st003712 1.76 µM -0.11336026615729 0.445593249108999 no 1890 0.454872469806653 2722 24207035 SGTC_3109 9122853 49.47 µM -0.114445404635738 0.445114958876299 no 1891 0.454442361360112 2674 1234709 SGTC_1883 5-benzylidenerhodanine 20 µM -0.114514040371166 0.445084709377716 no 1892 0.454415158503593 2682 1273210 SGTC_892 0929-0076 29 µM -0.115735066007532 0.444546626209537 no 1893 0.453931257162985 2622 5751038 SGTC_572 0960-0087 17.7 µM -0.117876705436956 0.443603093125583 no 1894 0.453082675457508 2612 6796365 SGTC_3137 9097352 49.47 µM -0.11901449053374 0.443101953596669 no 1895 0.452631937796329 2850 44120435 SGTC_819 1013-0258 27.7 µM -0.119220764841926 0.443011109421319 no 1896 0.452550228005247 2634 5753198 SGTC_2953 9074162 66.49 µM -0.11938844951644 0.442937262509358 no 1897 0.452483805897482 2661 16451992 SGTC_580 1123-0028 41 µM -0.120250383648182 0.442557705346277 no 1898 0.452142403461899 2606 1677248 YPR107C YTH1 SGTC_3295 9122362 53.5725 µM -0.121264615625469 0.442111150574929 no 1899 0.451740722892154 2693 4730473 SGTC_843 0310-0051 143 µM -0.121739556333199 0.441902064849782 no 1900 0.451552642394631 2634 2065037 SGTC_74 000s-0487 160.283 µM -0.122070144703062 0.441756537688539 no 1901 0.451421733048169 2604 677548 SGTC_573 3702-0553 84.7 µM -0.122546874603088 0.441546691918091 no 1902 0.451232962573959 2639 1222756 SGTC_1347 1493-0251 600 nM -0.122976181193065 0.441357734859067 no 1903 0.451062979717349 2716 3986378 SGTC_1054 3429-0080 167 µM -0.123467974820528 0.441141290861056 no 1904 0.45086826630666 2702 1162877 SGTC_1328 1441-0025 69.2 µM -0.12387146383935 0.440963723855727 no 1905 0.450708523728529 2615 4562601 SGTC_1397 3532-0190 20.1 µM -0.12613513169367 0.439967752451212 no 1906 0.44981247923876 2603 5322280 SGTC_2767 sibutramine 71.45 µM -0.126455426379464 0.439826859320127 no 1907 0.449685715164103 2721 64765 A serotonin-norepinephrine reuptake inhibitor.  SGTC_3279 9140807 49.47 µM -0.129042557396823 0.438689097626508 no 1908 0.448661987194711 2630 45595718 SGTC_656 4090-1979 187 µM -0.129452006423622 0.438509077386493 no 1909 0.448499999325851 2671 22330961 SGTC_960 1222-0186 7.7 µM -0.12969456228945 0.438402440158155 no 1910 0.448404042447687 2752 3126296 SGTC_2470 5664817 21.68 µM -0.129802267406845 0.438355090128075 no 1911 0.448361434481348 2637 2859561 SGTC_676 falcarinol 140 µM -0.130241709914124 0.438161908682997 no 1912 0.448187597930506 2673 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer. SGTC_149 3970-0822 46.1 µM -0.131548555898786 0.437587498939566 no 1913 0.447670689109737 2628 3114250 YBL034C STU1 SGTC_13 0199-0087 65 µM -0.131722758348938 0.437510940080408 no 1914 0.447601791903995 2636 4589825 SGTC_169 k015-0017 16.025 µM -0.133189123706438 0.436866591755022 no 1915 0.447021906118446 2713 1840002 SGTC_1965 Pectolinarigenin 58.4 µM -0.133600514540983 0.436685848944924 no 1916 0.44685923864624 2664 5320438 An anti-inflammatory. SGTC_583 1488-1091 88.9 µM -0.135006730284846 0.436068134076821 no 1917 0.446303276527521 2625 4303273 SGTC_2650 prasterone 100 µM -0.135878693219678 0.43568518111638 no 1918 0.445958589792987 2644 16759247 A steroid and weak partial agonist of the androgen receptor. SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM -0.136329434617864 0.435487245916029 no 1919 0.44578042782324 2780 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair. SGTC_1635 st007035 42.4 µM -0.136861752271679 0.435253508746862 no 1920 0.445570035775987 2627 3716403 SGTC_1798 st045719 60.953 µM -0.136914344006062 0.435230417289845 no 1921 0.445549250366695 2640 3980186 SGTC_1706 st031321 9.9705 µM -0.137190141765602 0.43510932636359 no 1922 0.445440251482343 2738 6103185 SGTC_334 1502-1024 68.5 µM -0.137996925427719 0.434755137359241 no 1923 0.445121423726828 2746 3296216 SGTC_1190 1486-1332 13 µM -0.138204494065649 0.434664020359323 no 1924 0.445039401716311 2634 4150046 SGTC_90 0870-0863 4.608 µM -0.139160296252657 0.434244493987009 no 1925 0.444661741081679 2632 1738164 SGTC_2608 thymoquinone 42.66 µM -0.140476088247001 0.43366707997246 no 1926 0.444141921978261 2621 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC). SGTC_898 1000-0849 28.3 µM -0.14313755525608 0.432499572189114 no 1927 0.443090772750589 2632 6751807 SGTC_1703 st026983 48.3 µM -0.144149906739188 0.432055637285057 no 1928 0.442691048166924 2734 1104023 SGTC_2264 7948757 110.76 µM -0.145196795550343 0.431596647343644 no 1929 0.442277747952432 2649 2971411 SGTC_53 0973-0023 39.979 µM -0.147319793639312 0.430666140386244 no 1930 0.441439804934736 2654 674768 SGTC_1396 3511-0007 98.6 µM -0.149206846067668 0.429839370922211 no 1931 0.440695209042539 2784 X1396 SGTC_3125 9127534 49.47 µM -0.149716830403014 0.429615985429717 no 1932 0.440494014553801 2637 1639235 SGTC_448 monastrol 171 µM -0.151992648419465 0.428619397636024 no 1933 0.43959636699827 2705 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM -0.152726278134555 0.428298235566331 no 1934 0.439307068457538 2700 6708514 SGTC_116 0155-0182 31.788 µM -0.153220294033094 0.428081996300555 no 1935 0.439112277154681 2689 771486 SGTC_2249 haloperidol 116.36 µM -0.154141858787393 0.427678669303527 no 1936 0.438748942057636 2663 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_2281 7943571 200 µM -0.154734483437222 0.427419344328548 no 1937 0.438515321766831 2774 1244024 SGTC_1124 fisetin 1.16336 µM -0.155912399835824 0.426903996370153 no 1938 0.438051035592385 2760 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster. SGTC_153 4077-0274 519.67 µM -0.156201650571567 0.426777465875132 no 1939 0.437937037869269 2762 3121976 SGTC_1560 lithocholic acid 53.1 µM -0.157404188873944 0.426251505722852 no 1940 0.437463156182784 2678 9903 A bile acid which acts as a detergent. SGTC_1147 3809-1045 12.3 µM -0.157647038243749 0.426145305373605 no 1941 0.437367467916773 2698 325925 SGTC_810 3825-7150 143 µM -0.158416405243149 0.425808889232093 no 1942 0.437064343745342 2817 22330411 YGL099W LSG1 SGTC_2911 7942208 15.64 µM -0.158420695319918 0.425807013489071 no 1943 0.437062653594339 2775 1243384 SGTC_1680 diphenhydramine 100 µM -0.158844729829912 0.425621621886655 no 1944 0.436895603433076 2758 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1 SGTC_397 arbidol 50 µM -0.159066319813804 0.425524747342954 no 1945 0.436808311610317 2831 131410 A RNA synthesis inhibitor. SGTC_807 1315-0151 48 µM -0.159935362415962 0.42514486339007 no 1946 0.436465995939518 2744 4011080 SGTC_2928 9011484 9.79 µM -0.160391658998976 0.424945430601268 no 1947 0.436286279857641 2788 2994751 SGTC_1548 st061468 90.8 µM -0.161073907654488 0.424647277160723 no 1948 0.436017595278595 2783 390799 SGTC_3246 9135460 32.98 µM -0.16132922173089 0.424535711951159 no 1949 0.435917054545344 2747 41446951 SGTC_3172 9105863 49.47 µM -0.161559682637874 0.424435012082347 no 1950 0.435826304356308 2732 2348785 SGTC_747 3448-8087 38.7 µM -0.162251534398645 0.42413273718331 no 1951 0.435553889408168 2749 5168703 SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM -0.163358461200446 0.423649205965066 no 1952 0.435118103323729 2818 5024745 SGTC_956 1185-0240 191 µM -0.166517493283079 0.422269902206977 no 1953 0.433874858852165 2741 1416193 SGTC_3053 9095903 49.47 µM -0.167301152091085 0.421927886148638 no 1954 0.433566548839101 2705 17174018 SGTC_2827 7993847 71.43 µM -0.16754326644557 0.421822230885743 no 1955 0.433471303458035 2811 2985692 SGTC_156 3474-0145 5.642 µM -0.167802478515353 0.421709120660214 no 1956 0.433369336288222 2645 2265471 SGTC_837 0091-0265 12.5 µM -0.168516720446964 0.421397486265316 no 1957 0.433088395377405 2706 759367 SGTC_3029 9088683 49.47 µM -0.168811964720022 0.421268681160532 no 1958 0.432972273455389 2833 25236615 SGTC_2711 st079103 59.1 µM -0.169154933350272 0.421119066109605 no 1959 0.432837388430915 2783 54693780 SGTC_1911 st060208 74.3 µM -0.170264279091509 0.420635208359804 no 1960 0.432401151096606 2812 688783 SGTC_2789 5281112 71.43 µM -0.171417962968625 0.420132139039269 no 1961 0.431947565707224 2766 765948 SGTC_1947 st076332 61.6 µM -0.171813388698605 0.419959741754733 no 1962 0.431792119696675 2795 24208416 SGTC_1949 st076024 69.1 µM -0.17291219529738 0.419480765965302 no 1963 0.431360222792685 2653 2921930 SGTC_3006 9075424 71.4286 µM -0.17328842558617 0.419316792507111 no 1964 0.431212360552841 2730 7465181 SGTC_435 c-PAF 6.7 µM -0.174063837738252 0.418978886771313 no 1965 0.430907646306478 2805 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase SGTC_487 nimodipine 119 µM -0.174628666253508 0.418732785861389 no 1966 0.430685711135108 2773 4497 L-type voltage-gated calcium channels inhibitor SGTC_346 4513-0042 7.16 µM -0.176787433156762 0.417792485380653 no 1967 0.429837680230883 2724 2827372 SGTC_2775 cyproheptadine 69.59 µM -0.179659961821384 0.41654201887574 no 1968 0.428709763871995 2734 2913 A selective serotonin reuptake inhibitor. SGTC_1359 1582-0056 520 nM -0.181087263612712 0.415921000299203 no 1969 0.42814954074453 2829 3661189 SGTC_2690 usnic acid 100 µM -0.182249097367262 0.415415641673341 no 1970 0.427693621997496 2918 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_2749 bexarotene 57.39 µM -0.182736870171243 0.415203518544531 no 1971 0.427502242310568 2831 82146 An retinoic acid receptor inhibitor. SGTC_1979 st071809 45.3 µM -0.182918299287838 0.415124624770169 no 1972 0.427431062192568 2856 4976333 SGTC_545 4218-0007 221 µM -0.183023828498814 0.415078737360598 no 1973 0.427389660984653 2838 2840508 SGTC_1860 st056228 74.6 µM -0.183636884584843 0.414812184285826 no 1974 0.427149162721444 2846 688679 SGTC_2478 5763493 32.33 µM -0.183671654061622 0.414797067901818 no 1975 0.427135523672571 2715 1365576 YLR208W SEC13 SGTC_2032 5185112 25.99 µM -0.18389990745169 0.414697835550351 no 1976 0.427045988706629 2820 5718189 SGTC_2270 7924575 90.91 µM -0.184008048051798 0.414650823708096 no 1977 0.427003570648678 2944 1262135 SGTC_2296 7971656 126.45 µM -0.18407716277826 0.414620778180558 no 1978 0.426976460898387 2797 666570 SGTC_2337 9009472 200 µM -0.184109824043376 0.414606579861627 no 1979 0.426963649873976 2879 5742383 SGTC_2093 5331342 194.4 µM -0.184671813897806 0.41436229232745 no 1980 0.426743227571264 2864 33839 SGTC_1290 0986-0249 10.2 µM -0.184838634177925 0.414289784729689 no 1981 0.426677802123963 2792 53329 SGTC_1775 st081588 35.1725 µM -0.188756321008836 0.412587826738791 no 1982 0.425141903571064 2747 1426443 YGL099W LSG1 SGTC_2276 7947513 42.08 µM -0.188785480822854 0.412575164978466 no 1983 0.42513047592207 2822 2105100 SGTC_1369 1866-0067 208 µM -0.18934209374658 0.41233349024119 no 1984 0.424912352956854 2812 3531355 SGTC_2523 spermine 47.74 µM -0.190714048198005 0.411737945979836 no 1985 0.424374815918396 2852 1103 A DNA binding polyamine. SGTC_900 1112-0045 141 µM -0.190922538661802 0.41164746124365 no 1986 0.424293140836719 2767 56211 YIL048W NEO1 SGTC_849 0386-0493 241 µM -0.190932461391788 0.411643154901882 no 1987 0.424289253738597 2749 726119 SGTC_1128 3448-9350 235 µM -0.190998911337203 0.411614316723884 no 1988 0.424263223041904 2861 619386 SGTC_1092 toremifene 6.32 µM -0.191397596666237 0.41144130391175 no 1989 0.424107051421873 2727 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_3111 9122088 49.47 µM -0.191893488056347 0.41122613175401 no 1990 0.423912819215928 2806 16876704 SGTC_1584 6-fluoro-dl-tryptophan 90 µM -0.192726426707914 0.410864771595793 no 1991 0.423586612959094 2939 94937 An inhibitor of serotonin biosynthesis. SGTC_3288 9119690 36.221 µM -0.194268518861303 0.410195953792746 no 1992 0.422982817165906 2800 17595618 YKL019W RAM2 SGTC_1590 st077108 57.8 µM -0.194567322578408 0.410066390352039 no 1993 0.422865843457793 2776 5489485 SGTC_2688 kanamycin b 96.69 µM -0.195387121738171 0.40971096999745 no 1994 0.422544948843637 2874 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis. SGTC_2427 5545055 42.75 µM -0.195459398232781 0.409679638392217 no 1995 0.422516660062254 2766 5372858 SGTC_1234 0326-0494 15.5 µM -0.196253557333577 0.409335411254681 no 1996 0.422205855163045 2904 1547813 SGTC_1332 1480-0653 17.5 µM -0.198433154443897 0.408391027874928 no 1997 0.421353089828647 2732 5749438 SGTC_288 1315-0019 35.1 µM -0.202553590925946 0.406607167957949 no 1998 0.419741983519486 2812 6811474 SGTC_1651 st011928 86.1 µM -0.202703116162934 0.406542470207091 no 1999 0.419683543698192 2882 720198 SGTC_966 1300-0360 30.2 µM -0.204563752989558 0.40573760921486 no 2000 0.418956488697711 2772 70588 SGTC_2976 9009005 19.48 µM -0.205155933330458 0.405481531469929 no 2001 0.41872514860433 2993 2993148 SGTC_873 0591-4978 488 µM -0.206508692955479 0.404896706795757 no 2002 0.418196787544807 2988 3305145 SGTC_1899 st063254 59.6 µM -0.206751121022378 0.404791922759605 no 2003 0.418102115520731 2749 3093813 SGTC_3076 9116187 49.47 µM -0.207585298300836 0.404431420745392 no 2004 0.417776392285413 2889 27241210 SGTC_2120 5538279 151.968 µM -0.207725793726202 0.40437071154913 no 2005 0.41772153823761 2798 2058197 SGTC_2566 crystal violet carbinol 226 nM -0.210087228937246 0.403350662219061 no 2006 0.416799796445127 2958 68050 Cationic dye that binds acidic phospholipids including cardiolipin. SGTC_1720 st037298 9.481 µM -0.210836356525418 0.403027204852116 no 2007 0.4165074838751 2873 597396 SGTC_3302 9125395 16.351 µM -0.212251272061705 0.402416455568822 no 2008 0.415955504262966 2831 17599668 SGTC_2100 5377183 190 µM -0.213283753331665 0.401970934492273 no 2009 0.415552822491374 2882 2844202 SGTC_1061 3448-9325 110 µM -0.2140715790052 0.401631069212647 no 2010 0.415245619355695 2742 723482 SGTC_1028 k015-0029 4.8 µM -0.214078368919074 0.40162814039018 no 2011 0.415242971935441 2770 4588309 SGTC_7 0192-1582 4.227 µM -0.214649510426836 0.401381798876433 no 2012 0.415020294887134 2813 252616 SGTC_2678 equilin 100 µM -0.216011703200908 0.400794423997647 no 2013 0.414489312542112 2885 3247 Equilin is an estrone commonly used hormone replacement therapy SGTC_199 4063-0024 41.6 µM -0.216893597769143 0.400414272255146 no 2014 0.414145633545385 2909 306215 SGTC_3324 9138759 60.749 µM -0.216902375790182 0.400410488852301 no 2015 0.414142213033936 2915 45595710 SGTC_2215 7188065 200 µM -0.217916246756821 0.399973564671724 no 2016 0.413747184126386 2917 940217 SGTC_3190 9110366 49.47 µM -0.21792438262973 0.399970059051093 no 2017 0.413744014543895 2872 17123768 SGTC_1196 1588-0294 184 µM -0.217960845203255 0.399954347996393 no 2018 0.413729809482649 2845 6144269 SGTC_2206 7254556 146.969 µM -0.21833341569747 0.3997938234839 no 2019 0.413584670230364 2835 4398905 SGTC_982 1491-0518 27.5 µM -0.219683837553492 0.399212127226202 no 2020 0.413058696476578 2810 3091256 SGTC_667 1498-1044 59 µM -0.220131411997526 0.399019383155144 no 2021 0.412884405765845 2829 6739982 SGTC_1503 4585-0012 61.3 µM -0.220618974511126 0.398809446584634 no 2022 0.4126945627763 2989 2922052 SGTC_1523 st012844 44.7 µM -0.22134126453308 0.398498493947324 no 2023 0.412413361108705 2916 4274103 SGTC_56 0957-0365 83.25 µM -0.221933810458996 0.398243445462557 no 2024 0.412182704921213 2851 6752360 SGTC_1708 st033234 31.827 µM -0.221970751822348 0.398227546295799 no 2025 0.412168326019973 2918 674664 SGTC_1434 4073-0095 163 µM -0.222113843706808 0.398165962677773 no 2026 0.412112630648415 2815 24133745 SGTC_1310 1188-0297 994 nM -0.223170572267432 0.397711248445923 no 2027 0.411701377154701 2844 1588352 SGTC_932 2857-0803 154 µM -0.223454814308386 0.397588961724209 no 2028 0.411590773479724 3025 674898 SGTC_1282 0886-0010 32.4 µM -0.225535448522266 0.396694137629543 no 2029 0.410781375853049 2949 2836211 YNL267W PIK1 SGTC_3051 9093778 49.47 µM -0.225826130755922 0.396569166302617 no 2030 0.410668326300129 2785 17217378 SGTC_1874 staurosporine 7.6 µM -0.226837588354281 0.39613439908381 no 2031 0.410275017085886 2934 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1 SGTC_1752 st044819 83.042 µM -0.22707970254681 0.396030347310554 no 2032 0.410180883411886 2839 441209 YML126C ERG13 SGTC_611 3453-1652 23.7 µM -0.22927578371952 0.39508689157631 no 2033 0.409327286996205 2903 1560575 SGTC_126 0417-1624 672.48 µM -0.229338733246295 0.395059856944542 no 2034 0.409302825414326 2878 41912 YDL195W SEC31 SGTC_3156 9099931 49.47 µM -0.229486116716027 0.394996562847877 no 2035 0.409245554994135 2800 18111053 SGTC_112 phenothiazine 287.218 µM -0.22953954831065 0.394973617237532 no 2036 0.409224792968507 2817 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.  SGTC_2656 pseudo-anisatin 100 µM -0.229863316124736 0.394834586505845 no 2037 0.409098991285277 2825 6708809 A neurotoxin. SGTC_1439 4092-1168 46 µM -0.229969079530393 0.394789173021715 no 2038 0.409057898387024 2857 2886240 SGTC_3020 9089140 49.47 µM -0.2313055536908 0.39421543108681 no 2039 0.408538716222978 2890 17217859 SGTC_2447 5741742 33.78 µM -0.231851106247125 0.393981293876227 no 2040 0.408326830658344 2897 1776504 SGTC_63 0099-0242 26.702 µM -0.232062962700889 0.393890380825873 no 2041 0.408244555569674 2970 3898502 YLR359W ADE13 SGTC_1987 st072290 61.9 µM -0.232719080630846 0.393608860461803 no 2042 0.407989775882357 2874 54697379 SGTC_1024 4507-0395 26 µM -0.233044328534303 0.393469327025515 no 2043 0.40786349202745 2990 4201836 SGTC_3208 9114115 49.47 µM -0.233086027420734 0.393451438924857 no 2044 0.407847302311831 2892 650895 SGTC_566 0958-0068 16.5 µM -0.23367277518028 0.393199758153066 no 2045 0.407619512460994 2987 6815365 SGTC_2806 7952793 58.44 µM -0.234656317263372 0.392777975775181 no 2046 0.407237747422316 2969 2972490 SGTC_2175 5807670 165.306 µM -0.234882435615455 0.392681024915291 no 2047 0.407149991295716 2939 241186 SGTC_439 amiodarone 34.4 µM -0.237586842299256 0.391521996923568 no 2048 0.406100778332337 2887 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1 SGTC_2589 lobaric acid 100 µM -0.23861539013572 0.391081444056887 no 2049 0.405701915103459 2852 73157 A novel microtubule depolymerizer. SGTC_390 dec-rvkr-cmk 16.7 µM -0.238847848694238 0.390981895556466 no 2050 0.405611782943445 2887 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1 SGTC_1802 st050112 57.9 µM -0.239218402676386 0.390823223576641 no 2051 0.405468116797238 2808 4662563 SGTC_666 0272-0154 136 µM -0.240265238932644 0.390375064413565 no 2052 0.405062320558407 2871 6870312 SGTC_2363 9053361 176 µM -0.240912670848446 0.390097966358589 no 2053 0.404811400708154 2998 6469797 YMR079W SEC14 SGTC_2303 7774051 200 µM -0.241484072364833 0.389853455362991 no 2054 0.404589979840203 3022 2953184 SGTC_1097 itavastatin 7.23 µM -0.241963327626542 0.389648408687513 no 2055 0.404404289649218 2856 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49 SGTC_285 1486-1325 46 µM -0.24457421243742 0.388531897067979 no 2056 0.403393066614011 2939 22310230 SGTC_3060 1327-0027 12.5 µM -0.244720057941216 0.388469555153007 no 2057 0.403336598099144 2924 16000455 YPR107C YTH1 SGTC_2550 chrysin dimethyl ether 71.87 µM -0.244923100817734 0.388382768905509 no 2058 0.403257987241062 2797 88881 An O-methylated flavonoid and antioxidant. SGTC_1245 0418-0076 17.2 µM -0.246275984015502 0.387804650954592 no 2059 0.402734299745642 3025 6790114 SGTC_45 0kpi-0036 14.9 µM -0.246801709899343 0.387580063258438 no 2060 0.402530843555882 2975 2795021 SGTC_2782 7736369 71.43 µM -0.246986691427012 0.387501048936178 no 2061 0.402459261883997 2883 2950836 YOL077C BRX1 SGTC_2059 5238311 157 µM -0.247093164203125 0.387455571511724 no 2062 0.402418061959139 2842 703021 SGTC_2877 9040724 71.43 µM -0.24790369658598 0.387109421707836 no 2063 0.402104459854673 3047 6463895 SGTC_877 0771-0151 33.1 µM -0.248576242076761 0.386822269362872 no 2064 0.401844293913842 2933 6166523 SGTC_1540 guanosine 70.6 µM -0.248634718803578 0.38679730486259 no 2065 0.401821674965729 2811 6802 Guanosine is a purine nucleoside SGTC_1795 st049545 62.3 µM -0.248972235412333 0.386653223644518 no 2066 0.401691129103796 2892 5291882 SGTC_1468 k284-1086 134 µM -0.249108771668583 0.386594942623645 no 2067 0.401638322245578 2877 15996457 SGTC_3101 9120531 49.47 µM -0.250117397918265 0.386164485988322 no 2068 0.401248280951348 3058 24824904 SGTC_2653 dihydrofissinolide 100 µM -0.25104154141274 0.38577020745501 no 2069 0.400890995961297 2898 6857746 SGTC_513 4245-1575 41.7 µM -0.25193789034746 0.385387899959322 no 2070 0.400544535857975 2969 719745 SGTC_934 2950-0684 338 µM -0.252546188062148 0.385128514422676 no 2071 0.400309458920606 3067 1121253 SGTC_2701 st077767 14.721 µM -0.255387453240126 0.383917646760484 no 2072 0.399211930219135 2892 5721188 SGTC_3266 9136860 49.47 µM -0.257191479638908 0.38314940818917 no 2073 0.398515480549499 2899 4871271 YPR165W RHO1 SGTC_1745 st081495 74 µM -0.257751239696559 0.382911129483286 no 2074 0.398299449114929 2852 13842402 YBL026W LSM2 SGTC_1533 dihydroergotamine mesylate 29.4 µM -0.26007448402648 0.381922645121171 no 2075 0.397403159826144 2875 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release. SGTC_614 0462-0418 107 µM -0.261499351647473 0.381316778518732 no 2076 0.39685372472008 2900 5188303 SGTC_787 4152-0075 138 µM -0.261509848807446 0.381312316108441 no 2077 0.396849677728114 2883 9566539 SGTC_698 k064-0052 127 µM -0.26255484283895 0.380868161483915 no 2078 0.396446854670639 2850 5088751 SGTC_1609 st001574 46.4 µM -0.264296984206362 0.380128046941914 no 2079 0.395775541970403 2866 3960012 SGTC_1828 st055811 49 µM -0.264403605542264 0.380082765181497 no 2080 0.395734466768966 3022 5877589 SGTC_2881 9058953 51.95 µM -0.2646972267445 0.379958073638655 no 2081 0.39562135702749 2831 17122249 SGTC_2473 5854593 8.94 µM -0.264701920348298 0.379956080516383 no 2082 0.395619549013097 2832 2872951 SGTC_114 0364-0001 490.298 µM -0.264821017974408 0.379905507197269 no 2083 0.395573672389719 2937 4003655 SGTC_2707 st078556 66.6 µM -0.264872319799212 0.37988372315107 no 2084 0.395553911278818 2949 17250899 SGTC_1279 0874-0590 65.2 µM -0.265761542661831 0.379506197353029 no 2085 0.395211431439599 2937 3523074 SGTC_1040 k898-0338 155 µM -0.26629558260511 0.379279522128482 no 2086 0.395005787444631 3091 20969351 SGTC_2482 5981709 142.65 µM -0.267100485093935 0.378937956722488 no 2087 0.394695897053091 2925 877755 SGTC_1563 conessine 56.1 µM -0.267610434503505 0.378721605392246 no 2088 0.394499599132214 3002 441082 An anti-amoebic, histamine inhibitor. SGTC_3353 9151644 39.2805 µM -0.268263032519628 0.378444789349335 no 2089 0.394248429698042 3001 4909158 SGTC_473 2-arachidonoylglycerol 10 µM -0.270371759889793 0.377550746028575 no 2090 0.393437131833375 2826 5282280 An endocannabinoid. SGTC_3123 9126162 49.47 µM -0.270618234582875 0.377446290139687 no 2091 0.393342334904214 2856 25239884 SGTC_1818 st052136 56.3 µM -0.271104348928065 0.377240301331039 no 2092 0.393155388416792 2974 674169 SGTC_1894 3',6'-dihydroxyflavone 78.7 µM -0.271304281611733 0.377155590871132 no 2093 0.393078506837776 3003 688662 SGTC_2734 clemastine 41.6 µM -0.272128369965323 0.376806491272844 no 2094 0.392761658157973 2904 26987 Clemastine is a selective histamine H1 antagonist. SGTC_955 1216-0110 33 µM -0.273642003067932 0.376165549849264 no 2095 0.392179875880467 2839 3619719 SGTC_492 tmb-8 126 µM -0.273656122451859 0.376159572661318 no 2096 0.392174450065232 2954 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1 SGTC_805 3852-0218 479 µM -0.2748429998932 0.375657235711802 no 2097 0.391718430306045 2879 6615355 SGTC_204 PMA1.184 62.41 µM -0.275657412658797 0.375312663471778 no 2098 0.391405604212721 2882 2252213 YGL008C PMA1 SGTC_525 k781-2675 26.7 µM -0.276326434502364 0.375029679492315 no 2099 0.391148677112149 2897 3651118 YDL195W SEC31 SGTC_1601 4'-hydroxyflavanone 55.5 µM -0.276631897393191 0.374900496643491 no 2100 0.391031384778171 3104 165506 SGTC_464 bw-b 70c 158 µM -0.27688117649289 0.374795084795874 no 2101 0.390935673367501 3024 5353454 SGTC_3147 9097027 49.47 µM -0.278110967268823 0.374275184184319 no 2102 0.390463588531508 2923 25236841 SGTC_2908 7930301 100 µM -0.278604274338491 0.374066700161716 no 2103 0.390274266049623 2898 2223178 SGTC_2630 antimycin a 100 µM -0.278838551672141 0.373967701540546 no 2104 0.390184363684296 2839 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain. SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM -0.278945385292513 0.373922559594801 no 2105 0.390143368943886 2951 4213774 SGTC_2896 9052656 71.43 µM -0.281123731861837 0.373002489387301 no 2106 0.389307749731989 3011 6469436 SGTC_1553 gossypol 38.6 µM -0.282434214721615 0.372449327927463 no 2107 0.388805291432923 2879 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_3209 9113616 49.47 µM -0.284568414036889 0.371549034972074 no 2108 0.387987406529382 3112 16649353 SGTC_1583 clindamycin 39.6 µM -0.285569180677607 0.371127112010056 no 2109 0.387604055557658 2894 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis. SGTC_1433 4060-0023 7.6 µM -0.285789137797585 0.371034398884767 no 2110 0.387519814047704 3028 3840627 SGTC_3316 9136639 10.545 µM -0.285840839954757 0.371012607229959 no 2111 0.387500013375868 3008 4903665 SGTC_483 fpl-64176 144 µM -0.286552841554541 0.370712551731819 no 2112 0.387227363820697 2914 3423 SGTC_1131 3454-3128 32.3 µM -0.28671534969729 0.37064407769951 no 2113 0.387165141734321 3060 710982 SGTC_3311 9131146 2.8755 µM -0.286846535766848 0.370588804447809 no 2114 0.387114914544735 2945 4900406 YPR165W RHO1 SGTC_304 1310-0298 97 µM -0.287739184419753 0.370212771516362 no 2115 0.38677319652261 2953 1550234 SGTC_733 4069-0007 56.1 µM -0.288225096024836 0.370008130803713 no 2116 0.386587219835816 2934 5717425 YNL287W SEC21 SGTC_1270 0831-1170 17.3 µM -0.288304744349203 0.369974590578042 no 2117 0.386556737903252 2901 6764716 SGTC_2534 helenine 20.12 µM -0.288334852979577 0.369961911971796 no 2118 0.386545215316579 2863 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58 SGTC_2474 5321570 43.32 µM -0.289759062864661 0.369362345398027 no 2119 0.386000283984947 3041 2841384 SGTC_3166 9102297 49.47 µM -0.290218643149428 0.369168938128396 no 2120 0.385824487262777 2972 25237072 SGTC_299 1273-0059 1.44 µM -0.290745174615317 0.368947396191606 no 2121 0.385623109475912 3015 2848077 SGTC_1692 fluoroquinolonic acid 71 µM -0.29241540261718 0.368244924026836 no 2122 0.38498451651838 3047 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2 SGTC_641 4092-0595 30 µM -0.292915701269945 0.36803459170137 no 2123 0.384793293550127 2997 786260 SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM -0.293192267081064 0.367918336664035 no 2124 0.384687597243249 2893 2333 A French combination drug. SGTC_1654 st012436 41.8 µM -0.29432601412797 0.367441890188398 no 2125 0.384254398073649 2992 4323132 SGTC_2044 5102272 200 µM -0.294854963935234 0.367219673772875 no 2126 0.384052338368638 3013 592666 SGTC_1415 3966-0071 78.1 µM -0.294998050484557 0.367159569507161 no 2127 0.383997684481996 2964 2893185 SGTC_411 enrofloxacin 100 µM -0.297017173812675 0.366311773718484 no 2128 0.383226698833848 3089 71188 A bacterial gyrase inhibitor. SGTC_1721 st082152 9.2685 µM -0.298379552426809 0.365740102096323 no 2129 0.382706746744929 2868 5296051 SGTC_1403 3909-7815 62.9 µM -0.299603328946078 0.365226843734499 no 2130 0.382239872315735 2908 6615483 SGTC_1842 st055362 61.2 µM -0.301013373339923 0.364635762872351 no 2131 0.381702148375402 2945 676032 SGTC_2078 5212016 200 µM -0.303100943059944 0.363761259023419 no 2132 0.380906467740143 2942 1899708 SGTC_1962 st076595 64.5 µM -0.303289854736193 0.363682156958976 no 2133 0.380834488530318 2944 279619 SGTC_1312 1218-2183 165 µM -0.303705898535087 0.363507969461964 no 2134 0.380675981884766 2940 6744073 SGTC_284 0988-0104 32.6 µM -0.304307027335045 0.363256341183959 no 2135 0.380446995920705 3017 4666532 SGTC_1762 st045503 25.4615 µM -0.305575854304699 0.362725412975934 no 2136 0.379963803543195 3017 4645554 SGTC_1700 st030840 7.9285 µM -0.306435136024831 0.362366004721035 no 2137 0.379636679777225 3044 5499307 SGTC_936 3005-4620 401 µM -0.307533243808309 0.361906880219613 no 2138 0.379218761645775 3151 777207 SGTC_143 4032-1194 15.74 µM -0.307662355688977 0.361852910919698 no 2139 0.379169633476459 2878 1806963 SGTC_2547 epiafzelechin trimethyl ether 100 µM -0.30793481555069 0.36173903058803 no 2140 0.379065966585601 2877 6708630 An antioxidant. SGTC_815 1582-0027 36.9 µM -0.30808547772424 0.36167606341908 no 2141 0.37900864562222 3033 3128206 SGTC_1839 st053978 48 µM -0.309167121427136 0.361224115470165 no 2142 0.378597201411076 3040 3788398 SGTC_203 k066-0004 30.888 µM -0.309531888040118 0.361071747058144 no 2143 0.378458479590601 3016 6795412 SGTC_3265 9137266 49.47 µM -0.31024767923332 0.360772814567792 no 2144 0.378186307622191 3037 17224265 SGTC_2761 levamisole 97.89 µM -0.310885729792951 0.36050642021312 no 2145 0.377943746642898 3112 26879 An alkaline phosphatase inhibitor. SGTC_438 sphingosine 6.67 µM -0.310915923449344 0.360493815647801 no 2146 0.377932269429181 2937 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes. SGTC_811 0416-0114 265 µM -0.311001952774487 0.360457902900666 no 2147 0.377899568549991 3048 6612453 SGTC_1936 st074407 74.3 µM -0.312586228763281 0.359796770833166 no 2148 0.377297521024971 2963 809813 SGTC_1854 st056233 32.9 µM -0.31268786028277 0.35975437341243 no 2149 0.377258909754157 3054 5393174 SGTC_2849 9019321 12.99 µM -0.313892315721884 0.359252044661894 no 2150 0.376801413407748 3087 16489627 SGTC_1421 4029-0249 71.4 µM -0.314592737493171 0.358960039367254 no 2151 0.376535447017164 3113 2894095 SGTC_1006 4099-6547 255 µM -0.314640700963481 0.358940046445993 no 2152 0.376517236317541 3049 3146833 SGTC_68 0986-0284 82.829 µM -0.316450304624237 0.358186020482072 no 2153 0.375830369790136 3136 423278 YIL048W NEO1 SGTC_2008 4012253 172 µM -0.317054689578717 0.357934308246407 no 2154 0.375601052470957 2928 603940 SGTC_2786 7743617 45.45 µM -0.318924544911288 0.357155948609946 no 2155 0.374891865656351 3002 583674 SGTC_678 1218-2179 85.9 µM -0.319181099970703 0.357049199402583 no 2156 0.374794594022799 3023 6820081 YOR116C RPO31 SGTC_1392 3455-1037 33.9 µM -0.321327542155482 0.356156532023111 no 2157 0.373981093286229 3122 981132 SGTC_1824 st053723 68.6 µM -0.321754623499782 0.35597901025178 no 2158 0.373819296422151 3033 675225 SGTC_132 0417-1715 25.805 µM -0.321868585262538 0.355931645876506 no 2159 0.373776126539569 3114 6769098 SGTC_3145 9085516 49.47 µM -0.322257148055814 0.355770169534203 no 2160 0.373628946881701 3066 25236195 SGTC_2375 9072683 200 µM -0.323503345107286 0.355252457949965 no 2161 0.373157037293833 3141 16798029 SGTC_1707 st032323 6.317 µM -0.324520482919618 0.354830103040404 no 2162 0.372772008753008 3012 3132057 YMR211W DML1 SGTC_365 0121-0052 13.6 µM -0.326325496262156 0.354081031150957 no 2163 0.372089049945204 3104 3101739 SGTC_1940 st075990 51.1 µM -0.326393377831988 0.354052871617679 no 2164 0.372063373583458 3240 1084979 SGTC_1900 st060200 72.8 µM -0.326957900058451 0.353818719952669 no 2165 0.371849863785237 2959 688945 SGTC_2138 5575593 77.673 µM -0.328213412781821 0.353298158621576 no 2166 0.371375153572378 2995 762213 SGTC_2304 7443016 91.4 µM -0.329448287095437 0.352786421988753 no 2167 0.370908437533132 2917 939854 SGTC_1448 4255-0083 152 µM -0.330012313430398 0.352552775834441 no 2168 0.370695329046463 3137 5399660 SGTC_3028 9087778 49.47 µM -0.330113768174917 0.352510754421585 no 2169 0.370657000172819 2983 17217395 SGTC_1368 1852-0141 284 µM -0.330725850733907 0.352257274919928 no 2170 0.370425787025355 3099 2838987 SGTC_421 streptovitacin 30 mM -0.331014167817063 0.352137897952158 no 2171 0.370316891946443 3156 91467 include heat shock SGTC_167 3672-0051 66.205 µM -0.331154265264575 0.352079896213146 no 2172 0.370263982001254 2920 3237971 SGTC_2725 haloperidol 53.21 µM -0.331245372005687 0.352042178961146 no 2173 0.370229575463238 2974 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_620 0109-0052 432 µM -0.332215751593263 0.351640542195531 no 2174 0.369863175265892 3147 493037 SGTC_1661 st013063 9.66 µM -0.332795922478152 0.351400490511585 no 2175 0.369644168181579 2995 721395 SGTC_2058 5236698 133 µM -0.333164405557883 0.351248057603784 no 2176 0.369505092485512 3012 766665 SGTC_1091 telmisartan 47.6 µM -0.333290981298635 0.351195701673952 no 2177 0.369457323242131 3089 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension. SGTC_29 0299-0004 12.984 µM -0.334277238654761 0.350787849677807 no 2178 0.369085182230654 3033 16871 A napthoquinone isolated from Swertia calycina. SGTC_861 0443-0273 110 µM -0.334508049849014 0.350692425959584 no 2179 0.368998108757611 3090 6149169 SGTC_1258 0671-0043 57.1 µM -0.335048148164201 0.350469171225549 no 2180 0.368794383062672 3042 4298767 SGTC_1185 1319-0113 81.3 µM -0.337282076522944 0.349546305178991 no 2181 0.367952134899443 3097 4672763 SGTC_272 doxorubicin 8.13 µM -0.338629820397342 0.348989963283673 no 2182 0.367444307534279 3000 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_2995 9067767 71.4286 µM -0.33943167861823 0.348659114100622 no 2183 0.367142278748847 3066 11673567 SGTC_735 3076-0345 636 µM -0.340307534263341 0.348297864839266 no 2184 0.36681247194092 3159 2888990 SGTC_1904 st060225 78 µM -0.340536436407235 0.348203476133678 no 2185 0.366726294150408 3018 66595 SGTC_3304 9125678 46.087 µM -0.34186359779019 0.347656401324304 no 2186 0.366226772811386 3003 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2 SGTC_1491 4138-0063 26.5 µM -0.341974873856371 0.347610546138695 no 2187 0.36618490064662 3094 23883227 SGTC_2247 cerulenin 830 nM -0.342114669528451 0.347552941614386 no 2188 0.366132299073605 3237 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12 SGTC_1173 0443-0020 122 µM -0.342296971127089 0.347477827289164 no 2189 0.366063707375759 3001 5331295 SGTC_2784 7567673 72.73 µM -0.342350994582338 0.34745556897801 no 2190 0.366043381658977 3029 3471247 SGTC_1866 st057638 64 µM -0.34323628840191 0.3470908922958 no 2191 0.365710353420347 3022 688802 SGTC_2948 9070189 9.45 µM -0.343727974700541 0.346888414411793 no 2192 0.365525435439631 3141 6473636 YDL196W YDL196W SGTC_3032 9089427 49.47 µM -0.34406233573799 0.346750748507206 no 2193 0.3653997036627 3109 17173707 SGTC_1809 st050081 57.6 µM -0.34457208439077 0.346540909494501 no 2194 0.365208047671359 3175 5036894 SGTC_1783 st039459 87.517 µM -0.344683646320232 0.346494991089149 no 2195 0.365166106953509 3202 729761 SGTC_2821 7996764 71.43 µM -0.345642546400523 0.346100405059941 no 2196 0.364805683525429 3237 2987135 SGTC_550 4123-0385 25.7 µM -0.346242000315754 0.34585381543928 no 2197 0.364580426401023 3016 5731123 SGTC_2287 7945887 168.79 µM -0.346518490003152 0.345740101466944 no 2198 0.364476545469899 3101 1245853 SGTC_2469 5655019 90.81 µM -0.347058497803407 0.345518048575136 no 2199 0.364273685911164 3149 2788239 SGTC_1480 1070-0044 41.2 µM -0.347167135416713 0.345473382869064 no 2200 0.364232879650905 3080 3124987 SGTC_2845 9003024 42.97 µM -0.348130593413127 0.345077357081828 no 2201 0.363871054727282 3237 2990173 SGTC_684 1140-0066 328 µM -0.348477351031263 0.344934865153265 no 2202 0.36374086020427 3083 6813534 SGTC_2860 9025725 38.96 µM -0.34849597609132 0.344927212242757 no 2203 0.363733867635519 2978 40546248 SGTC_350 k064-0020 19.8 µM -0.348507576954129 0.344922445559187 no 2204 0.363729512245346 3204 2790705 SGTC_452 diindolylmethane 8 µM -0.351875075304565 0.343539815931715 no 2205 0.362465976157505 3133 3071 Inhibits expression of several cancer promoting factors. SGTC_1436 4092-1007 8.32 µM -0.352390681370095 0.343328302177432 no 2206 0.362272644777749 3045 2881121 SGTC_1352 1496-0991 99 µM -0.352680533269322 0.343209419638613 no 2207 0.362163977481463 3010 3000039 SGTC_1192 1488-0095 21.4 µM -0.352920809979236 0.343110882087246 no 2208 0.362073904655102 3097 915875 SGTC_1681 tripelennamine 100 µM -0.353528026887145 0.34286190980561 no 2209 0.361846310554963 3108 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist. SGTC_568 1193-0097 7.48 µM -0.354173568656369 0.342597298307646 no 2210 0.361604405291895 3113 3646150 SGTC_1084 voriconazole 435 nM -0.354737489766699 0.342366206802826 no 2211 0.361393131166974 3151 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_2265 7929201 200 µM -0.355391941259319 0.342098090466144 no 2212 0.361147992645619 2967 1265108 SGTC_347 4534-1311 26.2 µM -0.355418479196749 0.342087220055907 no 2213 0.361138053507133 2994 2862016 SGTC_445 e6 berbamine 66 µM -0.355422667746438 0.342085504363563 no 2214 0.36113648479637 3116 6610268 A calcium/calmodulin antagonist. SGTC_404 fumagillin 50 µM -0.355756818153851 0.34194864188686 no 2215 0.361011345105124 3103 12015870 A methionine aminopeptidase binder. SGTC_1398 3558-0053 112 µM -0.355868186478433 0.341903031877267 no 2216 0.36096964085081 2963 4532369 SGTC_2818 7996756 12.99 µM -0.356049863714104 0.341828632365809 no 2217 0.360901611466494 2954 2241621 SGTC_1374 2889-5571 141 µM -0.358950881180597 0.340641456735526 no 2218 0.359815917450294 3085 2853281 SGTC_917 harmaline 728.087 nM -0.359093664997719 0.340583066318513 no 2219 0.359762510297323 3124 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7 SGTC_2730 imipramine 71.33 µM -0.359210847606924 0.340535148185955 no 2220 0.359718681118655 3068 3696 A tricyclic antidepressant. SGTC_1152 3909-8331 15.9 µM -0.359839294590448 0.340278208544199 no 2221 0.359483657976962 3063 16001939 SGTC_466 geldanamycin 89.2 µM -0.361775972933066 0.339486867105643 no 2222 0.358759724253063 3078 5288382 HSP90 inhibitor. SGTC_575 k072-0246 11.9 µM -0.363390131116185 0.338827849989704 no 2223 0.358156736438432 3073 6796779 SGTC_3019 9081971 49.47 µM -0.363432336263989 0.3388106253753 no 2224 0.358140974945584 3204 16451803 SGTC_864 0469-0573 172 µM -0.367114846501513 0.337309033621813 no 2225 0.356766676707865 3052 689425 SGTC_1476 4112-3294 3.34 µM -0.367800373195054 0.337029786123425 no 2226 0.356511045364698 3176 704369 SGTC_1416 3966-0321 25.3 µM -0.368324436650899 0.33681637079673 no 2227 0.356315666754695 3096 582530 YLR208W SEC13 SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM -0.36894634860337 0.336563176608809 no 2228 0.356083857709029 3237 5393153 SGTC_1339 1486-1321 22.7 µM -0.369616346492122 0.33629048845974 no 2229 0.355834184810546 3073 3469382 SGTC_2561 acetosyringone 100 µM -0.370199402664213 0.336053255522518 no 2230 0.355616960812866 3017 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent. SGTC_1691 st019933 84.6 µM -0.370439376053753 0.335955634504532 no 2231 0.355527569698985 3147 6176082 SGTC_1830 st055982 50.3 µM -0.370717852392132 0.335842364383179 no 2232 0.355423846033093 3169 455313 An antimicrobial agent. SGTC_2395 5646831 180.19 µM -0.370782277215224 0.335816161739633 no 2233 0.355399851340308 3226 6808628 SGTC_1156 4092-0367 4.88 µM -0.372000711688685 0.335320754646898 no 2234 0.35494615973325 3090 1357585 SGTC_661 1304-0007 33.6 µM -0.372795317797344 0.334997827405112 no 2235 0.354650393959994 3082 3117130 SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM -0.372944067318415 0.334937389270794 no 2236 0.354595036613025 3074 689007 SGTC_1845 st056753 3.01 µM -0.373574806694051 0.334681162263865 no 2237 0.354360340182931 3016 5375839 SGTC_422 cantharidin 155 µM -0.373694802743456 0.334632424645823 no 2238 0.354315696232778 2989 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_526 4469-0568 170 µM -0.374775336627982 0.334193680387266 no 2239 0.353913779065127 3060 2901964 SGTC_2779 methotrexate 400 µM -0.375919500227097 0.333729346508239 no 2240 0.353488371474715 3162 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2 SGTC_178 4092-0806 87.505 µM -0.376610611360532 0.333448997360269 no 2241 0.353231500376859 3144 2169044 SGTC_2021 4019055 173 µM -0.376956826140166 0.333308590329489 no 2242 0.353102844938544 3226 44827708 YER133W GLC7 SGTC_3168 9103419 49.47 µM -0.377456164232157 0.333106125440827 no 2243 0.352917317554642 3142 16649256 SGTC_257 daunorubicin 18.5 µM -0.37754864849137 0.333068631504453 no 2244 0.352882959176556 3160 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_988 1497-1057 103 µM -0.377973136496567 0.332896561724225 no 2245 0.352725275092495 3179 3533044 SGTC_2014 4013930 200 µM -0.379538351345599 0.332262393017355 no 2246 0.352144065288634 3166 64556 SGTC_3349 9149703 23.001 µM -0.3796495921813 0.33221734048347 no 2247 0.352102771453578 3049 4910494 SGTC_505 gw-5074 63.9 µM -0.382089350321634 0.331229849277929 no 2248 0.351197545424639 3176 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases. SGTC_1360 1598-0022 39.8 µM -0.382159706253079 0.331201390101997 no 2249 0.351171453679595 3183 761525 SGTC_2685 mycophenolic acid 18.85 µM -0.382452234782466 0.331083071929378 no 2250 0.351062975967383 3099 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_233 rapamycin 362 pM -0.383935596266009 0.330483360780726 no 2251 0.350513091243064 3137 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C SGTC_1470 k295-0292 231 µM -0.386515600299721 0.329441322856853 no 2252 0.34955742561428 3194 5045612 SGTC_192 3455-0609 60.9 µM -0.387409726713534 0.329080502418175 no 2253 0.349226452033886 3212 3769639 SGTC_2010 4012422 159 µM -0.388899270235529 0.328479757846207 no 2254 0.348675331013997 3130 952393 SGTC_1855 st056195 39.6 µM -0.389030321810527 0.328426924905757 no 2255 0.348626858078659 3243 4028379 SGTC_2328 6201408 200 µM -0.38927544090714 0.328328115290679 no 2256 0.348536200849397 3196 2890418 SGTC_2853 9015042 58.44 µM -0.389919947417586 0.328068366484043 no 2257 0.348297871581921 2991 6457456 SGTC_1273 0849-0096 14.1 µM -0.390533819491093 0.327821041246038 no 2258 0.348070926172755 3141 5286025 SGTC_2321 7390090 138.78 µM -0.390621706776221 0.327785638182098 no 2259 0.348038439136846 3123 649046 SGTC_1033 k072-0102 21.3 µM -0.391060789936103 0.327608788354842 no 2260 0.347876151248818 3250 5965931 SGTC_1770 st043884 66.3 µM -0.392099618483729 0.327190532688155 no 2261 0.347492304699596 3071 670149 SGTC_690 glyoxal 20.3 µM -0.392531693021751 0.327016633630587 no 2262 0.347332699416206 3151 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins. SGTC_2266 7929956 200 µM -0.392720499256483 0.326940655691676 no 2263 0.347262964222889 3086 2967153 SGTC_235 0330-0087 5 mM -0.392996895959211 0.326829443214572 no 2264 0.347160886996484 3119 46494818 YHR062C RPP1 SGTC_1982 st072467 71.9 µM -0.393871123878006 0.326477785429849 no 2265 0.346838095240137 3037 3163533 SGTC_1909 st060837 51.5 µM -0.394056145333358 0.326403380388012 no 2266 0.346769793886448 3106 678937 SGTC_373 0844-0104 25.9 µM -0.395179377680216 0.325951828946704 no 2267 0.346355255464378 3232 5375804 SGTC_1756 st041558 35.5 µM -0.396372708658804 0.325472376614267 no 2268 0.345915048101107 3281 3955792 SGTC_2659 sanguinarine 24.21 µM -0.396471727879518 0.325432605978534 no 2269 0.345878530288477 3077 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis. SGTC_2628 lathosterol 100 µM -0.397499381158229 0.325019970977085 no 2270 0.345499621400114 3257 6710616 SGTC_215 1287-0124 461.5 µM -0.397980287390079 0.324826945709193 no 2271 0.345322358263221 3133 5560863 SGTC_2499 avocadenofuran 51.48 µM -0.39995337889691 0.324035482548606 no 2272 0.344595427709936 3063 6857792 A insecticide and lysyl oxidase inhibitor. SGTC_559 1550-0661 158 µM -0.400358258842065 0.323873171834068 no 2273 0.344446331811464 3183 5830875 SGTC_2580 diallyl disulphide 81.36 µM -0.400496110638584 0.323817916614196 no 2274 0.344395573789647 3087 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.  SGTC_1554 st069299 38.7 µM -0.400911922236238 0.323651270120419 no 2275 0.344242485949727 3187 24207999 SGTC_2182 6325192 200 µM -0.401620312411515 0.323367447165061 no 2276 0.34398173930195 3211 736248 SGTC_2233 sulbentine 40.3845 µM -0.401960502650898 0.323231183369043 no 2277 0.343856547286072 3169 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58 SGTC_648 0375-0473 33.3 µM -0.402595340005413 0.322976961580138 no 2278 0.343622969180319 3114 1713139 SGTC_1513 0337-0559 19 µM -0.404095216804278 0.322376661747398 no 2279 0.3430713510957 3123 775073 SGTC_2154 5570129 200 µM -0.406154289120727 0.321553307631518 no 2280 0.342314619131084 3190 673366 SGTC_172 1112-0046 2.638 µM -0.406409821248021 0.321451189894187 no 2281 0.342220752303032 3106 2802135 YIL048W NEO1 SGTC_2558 carylophyllene oxide 100 µM -0.407301346601524 0.321095017293378 no 2282 0.341893336941985 3167 6708694 An oxygenated terpenoid and antifungal agent. SGTC_2140 5586273 200 µM -0.407535774430338 0.321001388519802 no 2283 0.341807262347552 3201 854421 SGTC_477 mead ethanolamide 10 µM -0.408052908608866 0.320794889129823 no 2284 0.341617415872633 3150 16061185 SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM -0.408194820972303 0.320738231097359 no 2285 0.341565325058042 3103 803109 SGTC_2622 2-methoxyxanthone 59.94 µM -0.409197635111226 0.320337980002193 no 2286 0.341197314880513 3131 71034 A hepatoprotective. SGTC_2090 5301565 104.445 µM -0.410101655883436 0.319977339122062 no 2287 0.340865689035463 3126 2056344 SGTC_1995 st072814 61.1 µM -0.410545785465398 0.319800224844481 no 2288 0.340702812078059 3121 5769371 SGTC_1326 1431-2094 10.8 µM -0.412225049061305 0.319130923471428 no 2289 0.340087239393483 3055 616278 SGTC_967 1306-0166 352 µM -0.412773792143915 0.318912339437677 no 2290 0.339886177270681 3272 4437607 SGTC_1335 1486-0900 202 µM -0.412823759135134 0.318892438921352 no 2291 0.33986787138438 3102 X1335 SGTC_2444 5485484 36.41 µM -0.413092222494367 0.318785526084873 no 2292 0.339769523724263 3235 6790631 SGTC_3301 9125354 19.7965 µM -0.413221320124714 0.318734119618979 no 2293 0.339722234561608 3135 41905162 SGTC_3173 9105693 49.47 µM -0.414612129318604 0.318180523033972 no 2294 0.339212933721655 3297 17096658 SGTC_2045 5106652 78.05 µM -0.414896990330781 0.318067187224996 no 2295 0.339108656580219 3237 673349 SGTC_1862 st057513 3.81 µM -0.417111465489346 0.317186709928324 no 2296 0.338298439473547 3092 5393163 SGTC_1315 1237-0019 3.69 µM -0.41857429727408 0.316605653349432 no 2297 0.337763638603991 3265 825140 SGTC_3224 9130643 49.47 µM -0.419029255397727 0.31642502996511 no 2298 0.337597375852959 3311 17644395 SGTC_3233 9132340 49.47 µM -0.420027024570981 0.316029057953727 no 2299 0.337232855837247 3140 17682950 SGTC_2489 cantharidin 73.42 µM -0.420512248978341 0.315836569301184 no 2300 0.33705564155147 3188 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_2520 obtusaquinone 4.71 µM -0.420862693962197 0.315697578732379 no 2301 0.33692767406526 3298 5967872 SGTC_2018 5133068 143 µM -0.421086960545981 0.315608645663168 no 2302 0.336845791424415 3108 785362 SGTC_2597 laccaic acid a 100 µM -0.422383565656929 0.315094685453205 no 2303 0.336372535755989 3240 5491415 A textile dye. SGTC_2103 5378138 10 µM -0.422439742169236 0.315072425771761 no 2304 0.336352037405826 3243 244142 SGTC_3292 9120825 59.784 µM -0.42360340884782 0.314611479401134 no 2305 0.335927534427216 3318 24824900 SGTC_2822 7994718 71.43 µM -0.426733381251355 0.313373083440564 no 2306 0.334786766976757 3174 1018011 SGTC_1358 1509-0022 2.48 µM -0.428410224927865 0.312710491652284 no 2307 0.334176240849588 3226 3258434 SGTC_912 3474-0017 2.18 µM -0.428543735742757 0.312657761853439 no 2308 0.334127649394713 3302 3360550 SGTC_3016 9080866 49.47 µM -0.428598036992573 0.312636316792596 no 2309 0.334107887171279 3152 17066299 SGTC_708 3448-5400 146 µM -0.428942766365452 0.312500188455754 no 2310 0.333982438194441 3259 3462195 SGTC_2662 daunorubicin 22.37 µM -0.430103532171653 0.312042008022804 no 2311 0.333560165374808 3183 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_54 0159-0055 9 µM -0.430759406459467 0.311783248107197 no 2312 0.333321659256459 3379 3319099 SGTC_2063 5246145 200 µM -0.432530256384735 0.311085064786829 no 2313 0.3326780333773 3274 711240 SGTC_79 0052-0007 94.094 µM -0.433209267271635 0.310817534904092 no 2314 0.332431373469341 3302 2801472 SGTC_1135 dihydrocapsaicin 536.708 nM -0.433550614194291 0.31068308217502 no 2315 0.332307401968788 3110 107982 A Capsaicinoid. SGTC_1194 1488-0194 225 µM -0.433902078292458 0.310544670818784 no 2316 0.332179775248196 3136 1391452 SGTC_502 l-744,832 89.3 µM -0.434284050495378 0.310394275364523 no 2317 0.33204109222695 3268 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.  SGTC_1938 st074717 56.4 µM -0.437116176303717 0.309280161136877 no 2318 0.331013548215172 3213 17250979 SGTC_1123 mangostin 811.285 nM -0.43819208787807 0.308857372704871 no 2319 0.330623521820489 3214 5281650 An antioxidant. SGTC_2349 9023730 187.07 µM -0.439538337338611 0.308328709324653 no 2320 0.33013575478959 3315 4126287 SGTC_1934 st074720 32.6 µM -0.440138227323486 0.308093264322516 no 2321 0.329918498247417 3137 17250992 SGTC_590 k048-0076 22.4 µM -0.441789173291738 0.307445708406543 no 2322 0.329320886913406 3276 6832814 SGTC_3356 9151811 4.48 µM -0.443974012930744 0.306589663716568 no 2323 0.328530686210718 3155 1859254 YPR165W RHO1 SGTC_1778 st046819 58.9 µM -0.444557144158554 0.306361364381194 no 2324 0.328319911939771 3190 671715 SGTC_2751 anetholtrithion 17.25 µM -0.444854051302352 0.306245152339866 no 2325 0.328212615081184 3289 2194 A chloretic substance that stimulates the liver to produce bile. SGTC_363 0455-0021 3.06 µM -0.444876158818566 0.306236500045075 no 2326 0.328204626392419 3170 4597466 SGTC_584 0986-0246 15.4 µM -0.445703968821808 0.305912595008552 no 2327 0.327905548668207 3321 53315 YDR232W HEM1 SGTC_368 fentichlor 4.58 µM -0.445775862586835 0.305884471613964 no 2328 0.327879579526543 3225 7329 A pesticide. SGTC_99 0109-0120 622.8 µM -0.446753413133391 0.305502187143996 no 2329 0.327526555763539 3372 759414 SGTC_3264 9137442 49.47 µM -0.44690745750877 0.305441965312411 no 2330 0.327470939622824 3397 17015726 SGTC_3328 9140624 29.0385 µM -0.447587992419318 0.30517598123266 no 2331 0.327225285311359 3301 4904392 SGTC_2825 7998094 58.44 µM -0.447637043492096 0.305156813808926 no 2332 0.327207582117975 3206 2987815 SGTC_3317 9138495 8.753 µM -0.448273668603608 0.304908091731897 no 2333 0.326977850806936 3253 17020139 SGTC_2939 9044578 71.43 µM -0.44833251755447 0.304885104674995 no 2334 0.326956617996629 3144 2653634 SGTC_1777 st045864 34.765 µM -0.4487358546573 0.304727577430926 no 2335 0.326811108304194 3277 4691462 SGTC_2197 6588183 93.1375 µM -0.450199704725009 0.304156160742389 no 2336 0.326283224585574 3187 884136 SGTC_58 0957-0393 9 µM -0.451199377451765 0.303766211125381 no 2337 0.325922929150595 3318 6997992 SGTC_1429 4049-0205 9.46 µM -0.451957348680297 0.303470692551032 no 2338 0.325649854455386 3264 22774478 SGTC_2512 diallyl trisulfide 49.23 µM -0.452243565168685 0.303359135594982 no 2339 0.325546763410432 3283 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent SGTC_332 4112-0506 40.9 µM -0.453476903680203 0.302878634106928 no 2340 0.325102685407653 3204 2790355 SGTC_18 0111-0177 500 nM -0.454337713517797 0.302543469648811 no 2341 0.324792887821087 3248 721752 SGTC_947 3447-0010 211 µM -0.454345690220162 0.302540364621786 no 2342 0.324790017645052 3280 748350 SGTC_992 3909-8734 162 µM -0.455713269463558 0.302008229320773 no 2343 0.324298089346365 3230 4288319 SGTC_3351 9150312 21.596 µM -0.456112914990487 0.301852803669639 no 2344 0.324154391751 3284 4904905 SGTC_3249 9135183 49.47 µM -0.456230458641472 0.301807096754651 no 2345 0.324112132430849 3345 4902779 SGTC_2855 9016525 58.44 µM -0.456748278826806 0.301605779131925 no 2346 0.323925992587813 3212 43811474 SGTC_2145 5634607 200 µM -0.457168048091836 0.301442625993234 no 2347 0.323775131227603 3183 308662 SGTC_1971 st069429 63.5 µM -0.457665968008747 0.301249149298031 no 2348 0.323596220750347 3295 1246522 YGL099W LSG1 SGTC_1074 carmofur 3.8 µM -0.458266686420125 0.301015802675031 no 2349 0.323380427415245 3248 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_3207 9114163 49.47 µM -0.458360148900877 0.300979504880418 no 2350 0.323346858652562 3421 849233 SGTC_2019 4016004 108 µM -0.458595712917032 0.300888028216509 no 2351 0.323262257899693 3244 45595336 SGTC_963 1269-2853 151 µM -0.458769298805728 0.300820627567756 no 2352 0.323199921896589 3192 3668223 SGTC_2414 st077232 92.9 µM -0.459611269085242 0.300493800538856 no 2353 0.32289763447219 3144 729801 SGTC_1355 1499-0035 1.68 µM -0.459780803204506 0.300428011997196 no 2354 0.322836781817627 3208 1548538 SGTC_781 4335-2806 94.4 µM -0.461690131223565 0.299687537704484 no 2355 0.32215177458388 3335 845254 SGTC_760 0568-0725 82.9 µM -0.463727029541847 0.298898501908728 no 2356 0.321421664579772 3329 3916171 SGTC_3091 9116372 49.47 µM -0.464537117822266 0.298584959538813 no 2357 0.321131486331222 3357 17169793 SGTC_1172 0370-0043 85 µM -0.464913793527557 0.29843921924286 no 2358 0.320996596118744 3328 376585 SGTC_1409 3909-8004 61.9 µM -0.464999563253413 0.298406038444224 no 2359 0.320965884679196 3264 2119279 SGTC_428 3448-4153 16.5 µM -0.46521250902819 0.298323665693796 no 2360 0.320889640794796 3137 3834874 SGTC_1742 st038235 28.8875 µM -0.465607321727122 0.298170969663675 no 2361 0.320748300596312 3300 564103 YBR002C RER2 SGTC_2723 salbutamol 83.58 µM -0.466247594044899 0.297923416456078 no 2362 0.320519142798928 3289 9884233 β2-adrenoceptor agonist SGTC_1052 3253-3998 198 µM -0.467723133290453 0.297353274934782 no 2363 0.319991297881754 3205 5450317 SGTC_1271 0832-2808 169 µM -0.470250709721619 0.296377791165403 no 2364 0.319087954198023 3344 3663794 SGTC_2864 9034755 47.6 µM -0.47126792597004 0.295985624821082 no 2365 0.318724708567818 3331 4930451 SGTC_2216 7189485 200 µM -0.471583586519176 0.295863976981827 no 2366 0.318612022277468 3312 731273 SGTC_1424 4048-1941 275 µM -0.471749602050364 0.295800007880349 no 2367 0.318552763843035 3349 X1424 SGTC_1615 st002656 86.5 µM -0.472380674351068 0.295556901113926 no 2368 0.318327548022764 3327 1584458 SGTC_2366 9070441 60.58 µM -0.473106298322366 0.295277483987678 no 2369 0.318068671763882 3224 6837235 SGTC_3318 9139014 38.6185 µM -0.474732230052972 0.294651825828827 no 2370 0.317488921199268 3250 16643984 SGTC_2357 9067248 200 µM -0.47542502698805 0.294385423641988 no 2371 0.317242029806892 3323 9150235 SGTC_952 1185-0122 232 µM -0.476516668581517 0.293965878974421 no 2372 0.316853167546025 3264 678600 SGTC_1444 4112-3581 28 µM -0.476575708240017 0.293943196466663 no 2373 0.316832142324798 3283 2877249 SGTC_2726 cimetidine 79.27 µM -0.477334410408053 0.293651781946669 no 2374 0.316562005744551 3273 2756 A P450 inhibitor, histamine H2-receptor antagonist. SGTC_1063 disulfiram 1.84 µM -0.477494594840627 0.293590272838416 no 2375 0.316504984436851 3273 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_1690 st023502 41.2 µM -0.477609181938165 0.293546276279145 no 2376 0.316464197217777 3321 24207482 SGTC_2425 5628681 7.85 µM -0.477804844263392 0.293471157348124 no 2377 0.316394556472732 3301 5714958 SGTC_2980 9014342 25.29 µM -0.478418153330526 0.29323575266047 no 2378 0.316176307792259 3381 2996599 SGTC_2660 2',4'-dihydroxychalcone 17.14 µM -0.478459365076519 0.293219937611496 no 2379 0.316161644709526 3315 5357218 A potent inhibitor of glutathione S-transferases. SGTC_1914 st062367 72.6 µM -0.479579130789404 0.29279037781437 no 2380 0.315763344321626 3229 978205 SGTC_872 0588-0139 234 µM -0.479965956945262 0.292642053128323 no 2381 0.315625800028439 3248 2047100 SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM -0.479980298065585 0.292636554837837 no 2382 0.315620701227903 3286 5379071 SGTC_1733 st037357 54.9 µM -0.481164983548481 0.292182520095138 no 2383 0.315199622847392 3147 1272339 YGL099W LSG1 SGTC_896 0964-0007 44.5 µM -0.481709953639956 0.29197376858127 no 2384 0.31500600209633 3341 6756758 SGTC_2569 tetrandrine 100 µM -0.482179294298672 0.291794042699119 no 2385 0.314839292224782 3234 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_1353 1498-1206 8.11 µM -0.484356365300765 0.29096104588971 no 2386 0.314066490053035 3368 6756808 SGTC_1616 st002734 56.1 µM -0.486078516376661 0.290302899951065 no 2387 0.313455749157004 3225 4026101 SGTC_2147 5545932 89.7195 µM -0.490251562044947 0.288711006231679 no 2388 0.31197794914032 3321 797404 SGTC_1161 k007-0610 110 µM -0.491047350390482 0.288407903794 no 2389 0.311696479031877 3405 5843850 SGTC_2652 actinonin 100 µM -0.4936580097778 0.287414602109629 no 2390 0.310773862418501 3251 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase. SGTC_2887 9044784 58.44 µM -0.493897329906873 0.28732362679579 no 2391 0.310689345191854 3303 6465546 SGTC_2438 5259590 200 µM -0.493948377594042 0.287304223257056 no 2392 0.310671318711415 3326 1201127 SGTC_2578 7,8-dihydroxyflavone 64.44 µM -0.495923045011247 0.286554116383284 no 2393 0.309974353197421 3240 1880 Intensifies effect of antibiotics on Staphylococcus aureus. SGTC_3239 9133757 49.47 µM -0.497651926360424 0.28589813874295 no 2394 0.309364698742457 3341 17036923 SGTC_2925 9010536 32.5 µM -0.500757973621413 0.284721429167639 no 2395 0.308270733081939 3297 2994177 SGTC_1228 0124-0032 52.5 µM -0.500969388654669 0.284641419801316 no 2396 0.308196333342802 3377 X1228 SGTC_2511 berberine 10.47 µM -0.501303831770248 0.284514872763397 no 2397 0.308078654490999 3270 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_3049 9092223 49.47 µM -0.501909315257661 0.28428583749098 no 2398 0.307865656194143 3341 8623917 SGTC_777 1315-0167 517 µM -0.502353778902797 0.284117767048512 no 2399 0.307709342995408 3322 4221767 SGTC_2885 9057732 51.95 µM -0.502355036591772 0.284117291530722 no 2400 0.3077089007289 3410 6471414 SGTC_991 3996-0057 64.7 µM -0.502916288663291 0.283905126548748 no 2401 0.307511564250828 3325 715343 SGTC_1868 st057644 42.7 µM -0.504118401090927 0.28345095830042 no 2402 0.307089088433493 3260 688665 SGTC_750 4073-0104 132 µM -0.504853084321779 0.283173560325146 no 2403 0.306831014025707 3311 22330957 SGTC_762 1165-0429 115 µM -0.505238223288181 0.283028193557986 no 2404 0.306695763321173 3379 5967793 SGTC_2514 salinomycin 42.74 µM -0.505285750203541 0.283010257492602 no 2405 0.306679074938671 3409 23682228 A polyether potassium ionophore. SGTC_3087 9117406 49.47 µM -0.505868592837026 0.282790344334627 no 2406 0.306474450858072 3367 42546093 SGTC_1459 k035-0031 35.7 µM -0.506050280132779 0.282721808437462 no 2407 0.306410676509835 3250 3877128 YMR208W ERG12 SGTC_1104 tacrolimus 29.8 µM -0.506258125199247 0.282643415121192 no 2408 0.306337727671085 3387 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41 SGTC_2865 9030313 51.95 µM -0.506653473638019 0.282494329645596 no 2409 0.306198990647699 3225 42562754 SGTC_2224 6650123 117.647 µM -0.507677636137039 0.28210829501039 no 2410 0.305839717316241 3323 2908370 SGTC_40 0327-0103 19.753 µM -0.507943725438872 0.282008040314768 no 2411 0.305746404487858 3263 409036 SGTC_324 1315-0088 19.6 µM -0.50823676226907 0.28189765243358 no 2412 0.30564365622799 3354 6787421 SGTC_859 0439-0102 54.6 µM -0.508669068668045 0.281734839295524 no 2413 0.305492103459507 3414 610143 SGTC_2510 benzyl isothiocyanate 8.31 µM -0.509784357759755 0.28131501397736 no 2414 0.305101272776252 3363 2346 DNA damaging agent; causes G2/M arrest. SGTC_308 4092-1169 104 µM -0.510088710787309 0.281200499645817 no 2415 0.30499465693216 3317 2268590 YDL196W YDL196W SGTC_3278 9139605 49.47 µM -0.510579710851058 0.281015805908569 no 2416 0.304822692921662 3439 7958859 SGTC_139 0099-0334 718.624 µM -0.511549406809579 0.280651219035006 no 2417 0.304483200873764 3367 97690 SGTC_1082 camptothecin 424.86 nM -0.511852254927972 0.28053740092741 no 2418 0.304377207772007 3115 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_820 1582-0060 59.9 µM -0.512219582898635 0.280399379620306 no 2419 0.304248669567237 3293 3848840 SGTC_3112 9123419 49.47 µM -0.51300446343358 0.280104575638754 no 2420 0.303974099240884 3395 17015854 SGTC_2292 7671323 168.05 µM -0.513179858099619 0.280038717304926 no 2421 0.303912757020726 3411 937504 SGTC_2156 5649887 115 µM -0.513329681014829 0.27998246676393 no 2422 0.303860362591757 3402 54680440 YKL052C | YBR257W ASK1 | POP4 SGTC_800 3448-7362 155 µM -0.515692116439694 0.279096222789256 no 2423 0.303034730810308 3422 15991913 SGTC_2787 5284540 71.43 µM -0.516304682377123 0.278866647709048 no 2424 0.302820813215302 3311 736958 SGTC_1675 st018485 24.5 µM -0.516984228890785 0.278612077465561 no 2425 0.302583584103662 3317 3323024 SGTC_1510 1123-0200 71.5 µM -0.517069805926421 0.278580026806966 no 2426 0.302553715139002 3494 5378812 YNL149C | YNL150W PGA2 | YNL150W SGTC_836 0330-0104 1.35 µM -0.518406643234677 0.278079582339595 no 2427 0.302087290312718 3376 46494820 SGTC_2378 9074213 121.43 µM -0.518645976420165 0.277990034372628 no 2428 0.302003820640351 3380 657714 SGTC_358 0075-0058 9.45 µM -0.518679577077871 0.277977463608707 no 2429 0.301992102928036 3505 1069125 SGTC_3165 9101544 49.47 µM -0.5195173535054 0.277664122266032 no 2430 0.30170000733881 3398 5002184 SGTC_761 k216-0224 480 µM -0.520724881460451 0.277212791912011 no 2431 0.301279219411782 3475 1340404 SGTC_1902 st060212 70.5 µM -0.521006442012256 0.277107606362017 no 2432 0.301181141863559 3441 688944 SGTC_3200 9114385 49.47 µM -0.521405403613528 0.276958595513986 no 2433 0.301042193993141 3414 17018030 YLR208W SEC13 SGTC_495 decylubiquinone 155 µM -0.522094018666521 0.276701492380613 no 2434 0.300802435417354 3364 2971 A Co-enzyme Q analog. A free radical scavenger. SGTC_878 0828-0289 13.7 µM -0.523458378480862 0.276192437054257 no 2435 0.300327653996902 3359 745350 YLR208W SEC13 SGTC_1852 st056254 31.4 µM -0.523977432249384 0.275998894034371 no 2436 0.30014711826579 3278 442583 SGTC_383 2324-0395 7.37 µM -0.525783088874284 0.275326126196859 no 2437 0.299519462852996 3421 3146421 SGTC_3321 9137793 26.8275 µM -0.526138449513457 0.275193817833636 no 2438 0.299396007786426 3402 4904192 SGTC_1010 4112-3296 15.2 µM -0.528303160149376 0.274388526590923 no 2439 0.298644469305528 3461 704384 SGTC_2317 5986382 200 µM -0.52867341013787 0.274250906943493 no 2440 0.298516012853653 3411 877883 SGTC_610 4215-0184 155 µM -0.52885276040586 0.274184255806671 no 2441 0.29845379717951 3393 5605015 SGTC_1603 st002045 67.8 µM -0.530400287080081 0.273609487968349 no 2442 0.297917213507427 3441 5887985 SGTC_3267 9137951 49.47 µM -0.531194124731946 0.273314879769459 no 2443 0.297642131961956 3309 16643986 SGTC_2963 9082507 9 µM -0.531413936091368 0.273233331391372 no 2444 0.297565983171133 3426 16459611 SGTC_2903 5923464 63.88 µM -0.531718264813465 0.273120447601506 no 2445 0.297460569889028 3423 2876576 SGTC_2263 7948595 193.29 µM -0.533263523416777 0.272547626075293 no 2446 0.296925587046968 3377 2971371 SGTC_840 0245-0196 390 µM -0.533777155826209 0.272357356646211 no 2447 0.296747860283291 3477 3827528 SGTC_996 3970-0799 1.8 µM -0.536386649598559 0.271391719004177 no 2448 0.295845678108265 3416 6615648 YGL040C HEM2 SGTC_1090 efavirenz 20.7 µM -0.536485433382019 0.271355197812392 no 2449 0.295811550280688 3407 64139 A non-nucleoside reverse transcriptase inhibitor. SGTC_1372 2752-0194 270 µM -0.536850296792289 0.27122032598688 no 2450 0.295685512925943 3413 823334 SGTC_1644 st010134 20.9 µM -0.538161629260533 0.27073586776472 no 2451 0.295232733931124 3425 3818134 SGTC_616 4092-0450 108 µM -0.539048022656578 0.270408643792358 no 2452 0.294926859479198 3401 787165 SGTC_1687 st020778 55.3625 µM -0.539729483217554 0.270157207983388 no 2453 0.294691802084229 3405 4259299 SGTC_2971 9092186 9.93 µM -0.540035323388061 0.270044401374693 no 2454 0.294586336191791 3292 25236400 SGTC_1857 st056007 79.3 µM -0.54081739057004 0.269756049613018 no 2455 0.294316727458396 3438 619834 SGTC_538 2922-0838 53.3 µM -0.540942869266186 0.269709799400015 no 2456 0.294273480720715 3478 777039 SGTC_794 k038-0031 316 µM -0.54424395643073 0.268494479632957 no 2457 0.293136803601236 3476 6624242 SGTC_1284 0929-0043 16 µM -0.544572112942371 0.268373816990261 no 2458 0.293023919450992 3383 1239883 SGTC_3331 9141060 1.957 µM -0.54562638824607 0.267986346230029 no 2459 0.292661390719046 3340 4906567 YPR165W RHO1 SGTC_2380 9035439 200 µM -0.547402720747262 0.267334140351205 no 2460 0.292051043247413 3502 6462575 SGTC_2529 gangaleoidin 93.61 µM -0.548582897460016 0.266901264804593 no 2461 0.291645862673362 3373 4565183 SGTC_2007 4011539 71.82 µM -0.548989494775715 0.266752211535481 no 2462 0.291506329605775 3418 45595301 SGTC_301 4119-0100 24.5 µM -0.550082608240349 0.266351699104459 no 2463 0.291131357443547 3402 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1 SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM -0.550142922951939 0.266329608895221 no 2464 0.291110674166813 3535 16725076 SGTC_3284 9108171 64.8615 µM -0.550856220286763 0.266068434720221 no 2465 0.290866120467053 3393 8687505 SGTC_1919 st067113 52.3 µM -0.553192617758752 0.265213870864867 no 2466 0.290065760720955 3443 1268243 SGTC_2992 9074591 71.4286 µM -0.553719511744375 0.265021346182631 no 2467 0.289885409890239 3466 17741321 SGTC_1151 3909-8316 15.3 µM -0.553855686924644 0.264971599936419 no 2468 0.289838806967414 3461 800431 SGTC_3337 9144342 33.5465 µM -0.554385549947019 0.264778080481392 no 2469 0.289657506598317 3432 17682949 SGTC_2838 9002687 71.43 µM -0.555635634017404 0.264321802906961 no 2470 0.289229983153959 3364 6457060 SGTC_465 cgp-37157 41 µM -0.556740184149188 0.263918978242887 no 2471 0.28885247870759 3368 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange. SGTC_3338 9144300 39.5675 µM -0.557406991114894 0.263675948190169 no 2472 0.288624694992595 3385 4901274 SGTC_37 0566-0070 1.56 µM -0.557411041801138 0.263674472192055 no 2473 0.288623311521855 3405 1626686 SGTC_748 act1.228 77.9 µM -0.558021426956188 0.263452106862395 no 2474 0.288414876381232 3422 4421505 YNR035C ARC35 SGTC_21 0849-0113 22.993 µM -0.55810461391714 0.263421808991094 no 2475 0.288386475081327 3400 1560156 SGTC_2576 guaiol 23.12 µM -0.558167799564612 0.263398797070613 no 2476 0.288364903416662 3384 227829 SGTC_549 1661-1316 519 µM -0.559905183638445 0.262766452164945 no 2477 0.287772056428289 3503 2857282 SGTC_2016 5121758 140 µM -0.560469347745797 0.262561283989416 no 2478 0.287579670816809 3454 2795203 SGTC_137 0438-0332 85.389 µM -0.562794752933578 0.261716475911161 no 2479 0.286787326841553 3485 2063393 YER012W | YPR107C PRE1 | YTH1 SGTC_2635 hydroquinidine 100 µM -0.562903281870929 0.261677081982732 no 2480 0.28675037266035 3434 442912 An experimental heart treatment. SGTC_1774 st048371 48.465 µM -0.563036475991862 0.261628739223403 no 2481 0.286705023051836 3355 4242727 SGTC_3198 9112019 49.47 µM -0.563563019326797 0.261437675390427 no 2482 0.286525780165709 3450 45595555 SGTC_2938 9059746 27.26 µM -0.566585638662586 0.260342262324863 no 2483 0.285497867205662 3435 6471769 SGTC_593 1203-0218 61.7 µM -0.566635879017219 0.26032407495503 no 2484 0.285480796631507 3503 3666956 SGTC_222 nsc-310342 10.666 µM -0.568162005610453 0.259771918260566 no 2485 0.284962483900923 3453 432556 SGTC_2134 5324836 1.464 µM -0.570038353028746 0.259093879968069 no 2486 0.284325842743962 3364 699272 SGTC_2407 paclitaxel 400 µM -0.57019260254589 0.259038180980538 no 2487 0.28427353642582 3509 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_3140 9094243 49.47 µM -0.570200529796238 0.259035318644109 no 2488 0.284270848403732 3519 19291112 SGTC_2508 celastrol 40.54 µM -0.570202829372554 0.259034488326343 no 2489 0.284270068651153 3427 122724 Celastrol is a natural product and antioxidant. SGTC_1227 3909-8010 46.6 µM -0.570365801561504 0.258975646772888 no 2490 0.284214809777747 3409 15982272 SGTC_1673 st016611 27.3 µM -0.570834742303533 0.258806373013407 no 2491 0.284055835003628 3501 5226799 SGTC_2689 tacrolimus 100 µM -0.571494430300074 0.258568342091032 no 2492 0.283832267375946 3432 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). SGTC_1789 tunicamycin 25 nM -0.5715336239375 0.258554203674816 no 2493 0.283818987341363 3489 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_3236 9132701 49.47 µM -0.571538184755447 0.258552558465863 no 2494 0.283817442012408 3438 24282524 SGTC_1275 0867-0008 21.1 µM -0.571908149991191 0.258419120174279 no 2495 0.283692101163617 3369 3422836 SGTC_1803 st050068 52.4 µM -0.573459052191095 0.257860132509351 no 2496 0.283166958350283 3546 3984059 YIL048W | YNL267W NEO1 | PIK1 SGTC_1850 st056238 17 µM -0.573678860761382 0.257780958270933 no 2497 0.283092567881637 3480 5393177 SGTC_1341 1486-1360 280 µM -0.57456647838035 0.257461370066971 no 2498 0.282792264250711 3396 3976547 SGTC_2460 5552655 174.22 µM -0.575959624997279 0.256960180687765 no 2499 0.282321236107509 3475 5401989 SGTC_382 3229-0966 23.2 µM -0.576829976181747 0.256647326605445 no 2500 0.282027158779512 3536 5722370 SGTC_1664 st014217 9.02 µM -0.577202199700958 0.256513588724989 no 2501 0.281901435636464 3538 3982782 SGTC_846 0335-0850 148 µM -0.578319873824174 0.25611223278081 no 2502 0.281524089592997 3478 6819598 SGTC_640 3381-0960 37.1 µM -0.578841963983849 0.255924862883105 no 2503 0.281347906490026 3507 1745025 SGTC_3290 9121031 71.43 µM -0.579385085779497 0.255730021000648 no 2504 0.281164682605565 3416 17014854 SGTC_915 methyl methanesulfonate (MMS) 110 mM -0.57978080633659 0.25558810726857 no 2505 0.281031221303316 3451 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks. SGTC_925 2064-1272 59.6 µM -0.580118851336357 0.255466909793086 no 2506 0.280917235992947 3404 6815817 SGTC_2312 7706453 155.7 µM -0.581378901737501 0.25501541533553 no 2507 0.280492556905982 3445 976098 SGTC_1672 st016598 6.51 µM -0.582226157903579 0.254712065968352 no 2508 0.280207178099476 3410 4665860 YNL267W PIK1 SGTC_850 0388-0143 75.9 µM -0.582894669290397 0.254472847338835 no 2509 0.279982104700533 3421 67273 SGTC_1766 st045414 44.774 µM -0.583229758410608 0.254352984100323 no 2510 0.279869320392295 3526 253960 SGTC_3154 9100113 49.47 µM -0.583371029496737 0.254302459518201 no 2511 0.279821777969084 3411 25237525 SGTC_1254 0550-0035 264 µM -0.583742147540251 0.254169756903786 no 2512 0.279696903060414 3499 15121435 SGTC_17 0960-0276 49.807 µM -0.584071183028308 0.254052132348042 no 2513 0.279586210838077 3503 6821114 SGTC_1041 0206-0046 107 µM -0.584928533223238 0.253745778524696 no 2514 0.279297885967122 3438 50494 SGTC_1870 st057514 26.5 µM -0.585550744701987 0.253523567492053 no 2515 0.279088728213006 3433 5393161 SGTC_2012 4023501 200 µM -0.586261309511075 0.253269927846355 no 2516 0.278849963482425 3411 3477460 SGTC_2071 5230951 39.92 µM -0.586867276633516 0.25305373031725 no 2517 0.278646424335817 3547 1799272 SGTC_851 0394-0702 453 µM -0.587561031059967 0.252806331211833 no 2518 0.27841348704763 3518 762646 SGTC_1618 st003135 44.5 µM -0.588380866549511 0.252514134694158 no 2519 0.278138338746877 3450 1270615 SGTC_1671 st016596 74.5 µM -0.589173284398913 0.252231879274362 no 2520 0.277872518300372 3530 2829167 SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM -0.589644993392894 0.252063937832871 no 2521 0.277714340115253 3494 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1 SGTC_2924 9010168 62.78 µM -0.590566988821536 0.251735852391257 no 2522 0.277405294413277 3489 2993929 SGTC_2394 5221648 200 µM -0.592302453934792 0.251118911845871 no 2523 0.276824036481061 3528 788586 SGTC_326 k292-0812 17.5 µM -0.59315916241725 0.250814655640852 no 2524 0.276537319889588 3489 3579357 SGTC_2755 lomerizine 42.69 µM -0.593950337677282 0.25053384670716 no 2525 0.27627266482365 3473 3949 A calcium channel blocker. SGTC_2516 gossypol 71.55 µM -0.594950686615812 0.250179035126655 no 2526 0.275938217332276 3553 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_516 3992-2719 87.3 µM -0.595452052864646 0.250001306935542 no 2527 0.275770669982865 3390 5350887 YDR037W KRS1 SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM -0.595461237784949 0.249998051618894 no 2528 0.275767601018389 3506 676296 Flavone; oxidizing agent. SGTC_1195 1502-0147 41.1 µM -0.596902110745583 0.249487656514687 no 2529 0.275286368986666 3519 817940 SGTC_100 0086-0128 49.5915 µM -0.59754565663099 0.249259874647077 no 2530 0.275071567001921 3482 93297 SGTC_1507 4075-3230 155 µM -0.597548412451239 0.249258899467468 no 2531 0.27507064734504 3460 659771 SGTC_2537 larixol 68.93 µM -0.59801743173056 0.24909296100192 no 2532 0.274914150926525 3526 6708759 SGTC_2811 7967822 32.47 µM -0.598758164164216 0.248831010486974 no 2533 0.274667082100507 3513 2232244 SGTC_2316 5844804 197.44 µM -0.599169431533605 0.248685634401912 no 2534 0.274529952538982 3520 776813 SGTC_2807 7945238 51.95 µM -0.600889968189667 0.248077944458494 no 2535 0.273956637657028 3509 17148797 SGTC_1768 st044301 37.178 µM -0.601941516329301 0.247706930259618 no 2536 0.273606533827659 3462 3931349 SGTC_2083 5306046 65.942 µM -0.604993099576501 0.246631930182514 no 2537 0.272591790828551 3531 539837 SGTC_3251 9135047 49.47 µM -0.605191515071624 0.246562119750158 no 2538 0.272525876463008 3505 17682963 SGTC_1199 1638-0010 4.46 µM -0.605831371380555 0.246337065079041 no 2539 0.272313367740227 3462 3111136 SGTC_2471 5466956 24.79 µM -0.606209521698843 0.2462041112286 no 2540 0.272187815383555 3453 724419 SGTC_1375 2910-0797 186 µM -0.606966867971697 0.245937951636233 no 2541 0.271936450045922 3472 742508 SGTC_834 0312-0008 75.7 µM -0.607173906526474 0.245865217486455 no 2542 0.271867753476042 3537 6385573 YIL048W NEO1 SGTC_3129 9127257 49.47 µM -0.609609125448152 0.245010574567645 no 2543 0.271060382604823 3408 837894 SGTC_2150 5556613 200 µM -0.610010491540402 0.244869868242953 no 2544 0.270927428841926 3514 743190 SGTC_1371 2421-0008 32.7 µM -0.610457807662622 0.244713104538951 no 2545 0.270779292340431 3502 2827552 SGTC_44 0929-0055 61.211 µM -0.610928190161848 0.244548315435294 no 2546 0.270623560635971 3446 1379590 SGTC_493 zm226600 134 µM -0.611139314726413 0.244474371605063 no 2547 0.270553677199906 3574 5240098 A potassium channel opener. YCR052W RSC6 SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM -0.611408831523687 0.244379994106825 no 2548 0.270464478703356 3459 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding. SGTC_3121 9125696 49.47 µM -0.613011512114753 0.243819184418584 no 2549 0.269934363881326 3570 1235365 SGTC_597 k018-0003 82.8 µM -0.614997001817926 0.243125386634213 no 2550 0.269278350219145 3587 6786234 SGTC_2507 purpurin 79.67 µM -0.615530989559459 0.242938975441829 no 2551 0.269102055091907 3448 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1 SGTC_395 anisomycin 6.25 µM -0.616488289984437 0.242604982563481 no 2552 0.268786149069838 3502 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_720 r052-1644 49.9 µM -0.616637433861261 0.242552970099622 no 2553 0.268736948852488 3534 1422863 YOR257W CDC31 SGTC_3333 9141820 12.094 µM -0.616770694539303 0.242506501854577 no 2554 0.268692992079885 3491 1939433 SGTC_792 4534-1957 155 µM -0.617076784536438 0.242399785965997 no 2555 0.268592040279283 3483 1717904 SGTC_1859 st055998 20 µM -0.618607648145102 0.241866444353148 no 2556 0.268087431108942 3583 676301 SGTC_2480 5767542 37.17 µM -0.618763019909257 0.241812349586098 no 2557 0.268036243554843 3550 2867358 SGTC_2481 5478948 45.16 µM -0.619050174770382 0.241712390045333 no 2558 0.267941652734709 3557 77792 SGTC_1165 k072-0275 30.3 µM -0.620382759447069 0.241248806674107 no 2559 0.267502910150447 3592 6153523 YGL055W OLE1 SGTC_485 niflumic acid 177 µM -0.621387458629059 0.240899608788782 no 2560 0.267172360876948 3559 4488 A COX2 inhibitor. SGTC_2803 7707263 71.43 µM -0.622263490002076 0.240595355809608 no 2561 0.266884312082437 3505 2199229 SGTC_1145 3546-0597 10.2 µM -0.623640000321791 0.240117705247554 no 2562 0.266432017453367 3501 875334 SGTC_2805 7950783 58.44 µM -0.623686612034033 0.240101539986496 no 2563 0.266416708538156 3532 1178958 YDL195W SEC31 SGTC_2890 9046729 58.44 µM -0.626338477229494 0.239182832669993 no 2564 0.265546476865586 3457 903329 SGTC_2343 7990716 14.84 µM -0.626864013109737 0.239000995319784 no 2565 0.265374189232435 3535 6456862 SGTC_1572 epiandrosterone 68.9 µM -0.628366582780128 0.23848151789138 no 2566 0.264881911544499 3537 441302 A steroid. SGTC_1932 st074806 40.9 µM -0.628687199731821 0.238370752347534 no 2567 0.264776929896768 3665 17251235 SGTC_2936 9038235 15.59 µM -0.630083239517016 0.237888782328076 no 2568 0.264320062438683 3569 4749415 SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM -0.630247353952841 0.237832158436168 no 2569 0.264266380786024 3561 688761 SGTC_1516 st013856 110 µM -0.630414286972853 0.237774569640835 no 2570 0.264211782873565 3543 5281404 A mutagen and neurotoxin. SGTC_1608 st001473 40.5 µM -0.63042418221355 0.237771156206496 no 2571 0.264208546669154 3478 7292267 SGTC_2092 5303694 80.6725 µM -0.630616727260487 0.237704741759984 no 2572 0.2641455794928 3539 1963699 SGTC_1036 k216-0215 33.5 µM -0.63183919788173 0.237283313226091 no 2573 0.263745978613058 3567 622330 SGTC_1274 0865-0114 173 µM -0.633297526684291 0.236781113295005 no 2574 0.26326968407016 3548 870624 SGTC_3350 9150499 3.57 µM -0.633301157465232 0.236779863704689 no 2575 0.263268498794705 3558 4910996 YPR165W RHO1 SGTC_274 sirtinol 40.1 µM -0.634574841102359 0.236341729321655 no 2576 0.26285287055104 3563 6836442 NAD-dependent acetyltransferase inhibitor. SGTC_2322 7413319 38.22 µM -0.634659130840844 0.236312750253103 no 2577 0.262825376978855 3588 1840400 SGTC_2562 3',7'-dimethoxyflavone 64.92 µM -0.635326721925043 0.236083299532595 no 2578 0.262607674515372 3654 688664 SGTC_534 k292-0788 63.4 µM -0.636084008228675 0.23582316926534 no 2579 0.262360834062747 3619 4146317 SGTC_1773 st048542 73.5835 µM -0.636341840351538 0.235734639179215 no 2580 0.262276819789066 3525 3237138 SGTC_1986 st071812 45 µM -0.637009518006972 0.235505468385281 no 2581 0.262059321931361 3562 11838594 SGTC_2213 7173844 200 µM -0.638894140507162 0.234859262389701 no 2582 0.26144590004866 3553 892728 SGTC_1629 st005085 44.9 µM -0.639341388186518 0.234706052538026 no 2583 0.261300434651635 3564 24207091 SGTC_2487 5918373 44.05 µM -0.640290383946178 0.234381146200807 no 2584 0.260991915601901 3634 2876279 SGTC_2230 bromochlorosalicylanilide 954.5 nM -0.641614350678894 0.233928277719653 no 2585 0.260561806429824 3546 77254 SGTC_793 0488-0545 106 µM -0.64451511871844 0.232937754390178 no 2586 0.259620728495593 3549 292548 SGTC_1863 st057641 20.1 µM -0.645166646280197 0.232715598530151 no 2587 0.259409599082991 3608 3921635 SGTC_2399 5884133 200 µM -0.645206835890446 0.232701898657609 no 2588 0.259396578427088 3597 722445 SGTC_961 1252-1571 372 µM -0.645316066198726 0.232664666391102 no 2589 0.259361191627077 3598 6813498 SGTC_1530 rhein 70.4 µM -0.650340140879854 0.23095574234218 no 2590 0.257736266848631 3624 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death. SGTC_1336 1486-0901 104 µM -0.652345189206906 0.230275692503055 no 2591 0.257089257218019 3567 5006114 SGTC_2914 7968218 45.32 µM -0.653963003906994 0.229727797538634 no 2592 0.256567820545181 3546 2977111 SGTC_2592 piperlongumine 83.33 µM -0.654792081143524 0.229447302426885 no 2593 0.2563008149042 3552 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_23 0213-0011 39.996 µM -0.655524184568401 0.229199775350944 no 2594 0.256065160307578 3635 627608 SGTC_177 1327-0068 8.361 µM -0.656825257997823 0.228760247016484 no 2595 0.255646640712133 3605 15389900 YOR207C | YLR033W RET1 | RSC58 SGTC_1408 3909-7976 48.8 µM -0.657782550803019 0.22843715697024 no 2596 0.255338934171097 3634 24152374 SGTC_984 1492-0255 2.91 µM -0.658570372049195 0.228171456668893 no 2597 0.255085846857019 3551 1585198 SGTC_691 1548-0686 185 µM -0.660129008483133 0.22764630380373 no 2598 0.254585522281049 3585 46495133 SGTC_470 aa-861 153 µM -0.660260735251013 0.227601952184111 no 2599 0.254543261365824 3583 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor. SGTC_3319 9138450 16.7555 µM -0.661906339571222 0.227048297198319 no 2600 0.254015624314152 3567 2029690 SGTC_1953 st076800 12.1 µM -0.662125991676023 0.226974453881226 no 2601 0.25394523976852 3576 297591 SGTC_1526 st051518 75 µM -0.662227718663845 0.226940259580223 no 2602 0.253912646199238 3569 673993 SGTC_2458 5808907 16.39 µM -0.664351444190491 0.226227058630804 no 2603 0.25323270115582 3680 2731747 SGTC_920 mycophenolic acid 780.421 nM -0.667564837788548 0.225150331028513 no 2604 0.252205704495616 3620 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_2871 9038510 12.99 µM -0.668404831039343 0.224869349752276 no 2605 0.251937606266999 3649 4945164 SGTC_2676 harmalol 100 µM -0.670136180429215 0.22429083368788 no 2606 0.25138549131525 3634 5459187 A monoamine oxidase inhibitor SGTC_2681 menadione 3.18 µM -0.670970277077852 0.224012429069275 no 2607 0.251119732306538 3639 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_281 1672-3440 14.9 µM -0.671763123348377 0.223747975092931 no 2608 0.250867254291928 3634 6833000 SGTC_2536 dehydroabietamide 32.04 µM -0.671804152413131 0.223734294674645 no 2609 0.250854192444763 3646 3983547 SGTC_1038 k292-0204 154 µM -0.672208115914791 0.223599625559386 no 2610 0.250725607482298 3589 4454212 SGTC_622 1348-1566 26.3 µM -0.676129470732384 0.222294763436551 no 2611 0.249479223497146 3662 7340407 SGTC_1735 st034310 56.75 µM -0.67615016341781 0.222287889323375 no 2612 0.249472655169755 3674 871153 SGTC_757 1066-0008 322 µM -0.678017724382628 0.221667984902348 no 2613 0.248880227602501 3645 6842497 SGTC_2205 7238770 200 µM -0.678300581350404 0.221574181658732 no 2614 0.248790565077316 3657 279867 SGTC_1800 st050079 29.0735 µM -0.678314110681024 0.221569695524721 no 2615 0.248786276860413 3609 3645560 SGTC_1537 2',6'-dihydroxyflavanone 78 µM -0.679986730250632 0.221015478685558 no 2616 0.248256431581062 3655 5106787 A p450 inhibitor. SGTC_3134 9127454 49.47 µM -0.681384277011999 0.220553015319505 no 2617 0.247814184509697 3728 24262820 SGTC_951 1171-0579 82.7 µM -0.68154311527017 0.220500489131036 no 2618 0.247763947524019 3644 1616050 YPR165W | YDR526C RHO1 | YDR526C SGTC_625 k213-0058 121 µM -0.681680615566787 0.220455024977603 no 2619 0.247720463649304 3704 3655420 SGTC_721 1187-1332 279 µM -0.681881906324343 0.220388478346661 no 2620 0.247656813667457 3581 25730 SGTC_176 1486-1328 72.834 µM -0.681920801586383 0.220375620918644 no 2621 0.247644515636272 3647 22310231 SGTC_1389 3405-0187 19 µM -0.683190632066802 0.219956095118522 no 2622 0.247243195694815 3596 799890 SGTC_687 k029-0044 34.9 µM -0.683595902177389 0.219822298763074 no 2623 0.247115186503448 3671 5829338 SGTC_2800 7887935 81.82 µM -0.684511274307553 0.219520268701836 no 2624 0.246826186276137 3637 2961002 SGTC_600 1495-0418 41.6 µM -0.685148526863407 0.219310145925532 no 2625 0.24662510050976 3651 5377768 SGTC_2033 5192550 145 µM -0.68561132480028 0.21915761896146 no 2626 0.246479119115343 3641 182073 SGTC_1178 0988-0033 191 µM -0.686030454389545 0.219019536667135 no 2627 0.246346952089372 3661 5392207 SGTC_2052 5265182 7.135 µM -0.687003333783382 0.218699214367065 no 2628 0.246040313799329 3648 1239884 SGTC_2506 ethyl hematommate 54.16 µM -0.690386485532639 0.21758740696872 no 2629 0.244975586593061 3667 3940691 An allergen. SGTC_780 0109-0199 192 µM -0.691070075412237 0.217363155161248 no 2630 0.244760752337931 3678 610414 SGTC_1311 1190-0148 100 µM -0.691830117387462 0.217113979974774 no 2631 0.244522010331318 3709 1961333 SGTC_1722 st034304 3.6505 µM -0.693053152721099 0.216713361859258 no 2632 0.244138097796935 3682 4036148 YLR033W RSC58 SGTC_3255 9139072 49.47 µM -0.693313853502862 0.21662802187958 no 2633 0.244056305497481 3679 17646060 SGTC_1298 1079-1278 263 µM -0.693646042460773 0.216519308532061 no 2634 0.243952105906642 3699 2840950 SGTC_2400 5203494 178.7 µM -0.694091345646089 0.216373626548792 no 2635 0.243812462797736 3628 6777674 SGTC_3283 9109332 35.8195 µM -0.69806317332602 0.215076745865688 no 2636 0.242568843752207 3569 17027281 SGTC_403 arphamenine a 50 µM -0.699262448396344 0.21468604759661 no 2637 0.242194015052942 3633 5487158 An arginine aminopeptidase inhibitor. SGTC_2679 rapamycin 1 nM -0.699325098884649 0.214665648744574 no 2638 0.242174442522967 3668 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2 SGTC_2990 9074105 71.4286 µM -0.699421110482087 0.214634389779642 no 2639 0.242144449371006 3628 6502001 SGTC_97 0535-0701 19.132 µM -0.700152197917989 0.214396452855809 no 2640 0.241916130356214 3622 2832013 YGL099W LSG1 SGTC_1527 coumarin 137 µM -0.700260623275624 0.214361178219303 no 2641 0.241882279003994 3693 323 A hepatotoxic, DNA x-linker. SGTC_2900 5328528 85.29 µM -0.700818485340743 0.214179739158368 no 2642 0.241708150185179 3693 795359 SGTC_2733 amorolfine 100 µM -0.701299824308927 0.214023260304579 no 2643 0.24155796167643 3681 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_2989 9073649 71.4286 µM -0.701321036364464 0.214016365992383 no 2644 0.241551344207338 3659 21367202 SGTC_1003 4049-0218 100 µM -0.703791141443784 0.213214420312332 no 2645 0.240781425618886 3697 295161 SGTC_1021 4476-0760 85.3 µM -0.704328894396201 0.2130400657131 no 2646 0.240613988065734 3685 746768 SGTC_1107 amlodipine 47 µM -0.704535112697295 0.212973226024266 no 2647 0.240549795682411 3564 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.  SGTC_1543 azetidyl-2-carboxylic acid 198 µM -0.707678540097139 0.211955890903388 no 2648 0.239572453481588 3692 16486 A toxic proline analog. SGTC_712 r015-0009 80.6 µM -0.708082693567177 0.211825297690398 no 2649 0.239446953117243 3688 6813872 YLR060W FRS1 SGTC_2703 st077852 53.4 µM -0.709183636756567 0.211469791248 no 2650 0.23910526325279 3673 6281836 SGTC_2835 9006588 71.43 µM -0.709286869542242 0.211436474192924 no 2651 0.23907323749091 3695 2345538 SGTC_3161 9100388 49.47 µM -0.709484958813871 0.211372552035193 no 2652 0.239011791101713 3713 25236368 SGTC_722 3534-0461 190 µM -0.710610058532294 0.211009704236243 no 2653 0.238662954138943 3680 658262 SGTC_2852 9023854 51.95 µM -0.710878286409733 0.210923253929747 no 2654 0.238579831280618 3765 19798528 SGTC_3104 9120930 49.47 µM -0.711076837090747 0.210859274081516 no 2655 0.238518311343267 3700 17014836 SGTC_2350 9023895 38.85 µM -0.713125988598357 0.210199632210316 no 2656 0.237883899551645 3705 2997209 SGTC_154 3389-1638 511.116 µM -0.713956358821389 0.209932673389093 no 2657 0.2376270828512 3626 5238686 SGTC_1441 4106-0040 13 µM -0.715652936518743 0.209387854156639 no 2658 0.237102838996429 3689 2904180 SGTC_159 3970-0959 50 µM -0.715878557961556 0.209315463443066 no 2659 0.237033169698887 3784 6615653 SGTC_828 2074-0507 139 µM -0.717643054823154 0.208749832291295 no 2660 0.236488701660627 3744 X828 SGTC_2486 5283202 22.39 µM -0.717769819782764 0.208709230936761 no 2661 0.236449612513498 3717 1377751 SGTC_2907 7721985 69.9 µM -0.718548940126626 0.208459789906073 no 2662 0.236209441668071 3673 3267881 SGTC_1713 st033146 12.748 µM -0.719861661939462 0.208039910372663 no 2663 0.235805087446426 3682 674619 SGTC_2364 9055074 200 µM -0.720799539138318 0.207740232432032 no 2664 0.235516429507578 3718 6470630 SGTC_520 3584-0023 682 µM -0.723720492060994 0.206808541684546 no 2665 0.234618674943425 3730 1340790 SGTC_1645 Cervolide 78 µM -0.726746094112283 0.205846084152297 no 2666 0.23369075543059 3677 23173 A fragrance. SGTC_965 1291-5240 308 µM -0.726977257415693 0.205772659508722 no 2667 0.233619943894976 3689 2834598 SGTC_2091 4-phenylthiadiazole 200 µM -0.727989487284258 0.205451326939488 no 2668 0.233310010820595 3724 270010 SGTC_2448 5185112 27.17 µM -0.728758324098845 0.205207458780963 no 2669 0.233074754434457 3707 5718189 SGTC_322 k048-0136 19.3 µM -0.729976342301005 0.204821466569408 no 2670 0.232702322804603 3742 6823282 SGTC_2668 2',4'-dihydroxychalcone 15.08 µM -0.730566609907394 0.204634565104935 no 2671 0.232521956600784 3763 5357218 A potent inhibitor of glutathione S-transferases. SGTC_3163 9099914 49.47 µM -0.730743450475942 0.204578590327479 no 2672 0.232467935125194 3727 16268368 SGTC_680 0417-1641 114 µM -0.733200791095645 0.203801719483102 no 2673 0.231717986463988 3719 2835990 SGTC_2432 5630864 12.22 µM -0.733683041955045 0.203649465962307 no 2674 0.231570968119165 3720 5714970 SGTC_1011 4112-3381 17.4 µM -0.734440112029184 0.203410584928853 no 2675 0.231340273676992 3781 2877139 SGTC_3248 9135562 49.47 µM -0.73504204208783 0.203220775133229 no 2676 0.231156945018225 3758 17650701 SGTC_3312 9133330 71.43 µM -0.736226233839029 0.202847666384545 no 2677 0.230796514787997 3776 17617324 SGTC_1447 4239-0816 81.9 µM -0.736253739953324 0.202839004772234 no 2678 0.230788146535126 3736 1341554 SGTC_2192 5915882 198.485 µM -0.737331760007148 0.202499712775287 no 2679 0.230460311342518 3698 2876149 SGTC_1945 st075991 56.6 µM -0.73843521307556 0.20215276773021 no 2680 0.230125011521772 3690 1084980 SGTC_3219 9131112 49.47 µM -0.74084699847475 0.201395699261802 no 2681 0.229393107449847 3691 17612988 YMR079W SEC14 SGTC_1163 k060-0048 49.9 µM -0.742273937939413 0.2009485788397 no 2682 0.228960689472867 3749 6809982 SGTC_2902 5787006 60.46 µM -0.743473339400038 0.20057321675613 no 2683 0.228597578409576 3710 591003 SGTC_1361 1608-0041 5.61 µM -0.744232423281124 0.200335873205973 no 2684 0.228367937876171 3710 X1361 SGTC_1385 3091-4834 14.1 µM -0.745040378017919 0.200083434621189 no 2685 0.228123655262393 3727 4072814 SGTC_2727 riluzole 51.77 µM -0.745656964066748 0.19989091625883 no 2686 0.2279373312746 3748 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.  SGTC_1461 k072-0203 53.8 µM -0.745766679229574 0.199856671269613 no 2687 0.227904185806954 3686 5418714 SGTC_418 lividomycin a 100 µM -0.747622802584058 0.199277861273265 no 2688 0.227343853362211 3747 72394 An antibiotic. SGTC_2259 7964009 200 µM -0.748337733951231 0.199055188000663 no 2689 0.227128234835847 3758 313134 SGTC_2697 mebhydrolin 72.4 µM -0.749278485551385 0.198762409052808 no 2690 0.22684468616458 3749 22530 H1 Histamine receptor antagonist. YIL048W NEO1 SGTC_1174 0739-0097 51.1 µM -0.749395976761532 0.198725861905375 no 2691 0.226809287579598 3767 728447 SGTC_2598 perillyl alcohol 100 µM -0.750119256553512 0.198500965714701 no 2692 0.226591441370669 3769 10819 An apoptosis inducer. SGTC_751 0833-0568 350 µM -0.751194991872513 0.198166761349383 no 2693 0.226267656890082 3827 6954252 SGTC_3242 9133940 49.47 µM -0.751416964574647 0.198097842222614 no 2694 0.226200878098396 3775 17248444 SGTC_446 go6976 132 µM -0.753126347967706 0.197567589861609 no 2695 0.225686996396432 3720 3501 A protein kinase C inhibitor. SGTC_3005 9076496 71.4286 µM -0.755491224884326 0.19683541904149 no 2696 0.22497714776682 3777 21368410 SGTC_2068 5226020 147 µM -0.755689793589834 0.196774016615433 no 2697 0.224917602421949 3814 1810509 SGTC_1309 pyrazolanthrone 13.4 µM -0.757058950692602 0.196350954701923 no 2698 0.224507272750224 3767 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14 SGTC_2791 5663188 71.43 µM -0.757303733741195 0.19627537624395 no 2699 0.224433957255413 3736 54690634 SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM -0.757579838141845 0.196190148271904 no 2700 0.224351276944659 3765 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_3148 9097893 49.47 µM -0.757897632682134 0.196092079162094 no 2701 0.224256133799976 3756 17174100 SGTC_2396 5342950 42.78 µM -0.761320851791318 0.195037584479957 no 2702 0.223232724475952 3791 1886677 SGTC_2433 5607874 27.82 µM -0.761582026457153 0.194957273546296 no 2703 0.223154752715177 3772 2252428 SGTC_297 0986-0032 24 µM -0.761839738350042 0.194878047124336 no 2704 0.22307782994005 3757 2847425 SGTC_1725 st036284 20.55 µM -0.762007682702507 0.19482642779868 no 2705 0.223027709431071 3829 707914 SGTC_2006 4011487 200 µM -0.763139388768412 0.19447880383719 no 2706 0.222690135746306 3828 45595294 SGTC_2385 9074692 200 µM -0.764045894966919 0.194200626588642 no 2707 0.222419946544997 3789 17046906 SGTC_668 1682-0499 62.6 µM -0.765275937256888 0.193823554387859 no 2708 0.222053624770606 3800 682214 SGTC_2728 chlorpromazine 9.18 µM -0.766527525991084 0.193440335506389 no 2709 0.221681239973977 3787 2726 A thorazine and dopamine antagonist. SGTC_1594 piperine 70.1 µM -0.766989407234506 0.193299030808198 no 2710 0.221543906786414 3769 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_1257 0669-0121 16 µM -0.767304880197299 0.193202553444429 no 2711 0.221450133776205 3807 4307855 SGTC_802 4112-3352 742 µM -0.767622838803978 0.193105345671659 no 2712 0.221355644884086 3871 704594 SGTC_2268 7933382 153.85 µM -0.767867550067527 0.193030551752674 no 2713 0.221282938868722 3815 935025 YOR257W CDC31 SGTC_1906 st060206 94.7 µM -0.768261515686822 0.192910176676965 no 2714 0.221165916682151 3759 5133468 SGTC_2684 capsaicin 100 µM -0.768980971255503 0.192690467422567 no 2715 0.220952303478209 3796 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_3310 9130229 44.1445 µM -0.7720093936568 0.1917673173765 no 2716 0.22005443194283 3872 7761258 SGTC_2441 5730946 39.09 µM -0.772620362536702 0.191581405337998 no 2717 0.219873544974854 3854 1774275 SGTC_1637 st007924 17.4 µM -0.773130908303983 0.191426135807634 no 2718 0.219722455324141 3763 683336 SGTC_937 3122-0005 46.7 µM -0.773452099439604 0.191328493206924 no 2719 0.219627433368768 3829 759535 SGTC_565 1418-0001 44.5 µM -0.773868304977545 0.191202011497157 no 2720 0.219504337234503 3831 2862145 SGTC_605 1315-0399 119 µM -0.774086466377317 0.191135734381925 no 2721 0.219439830081043 3882 24020461 SGTC_1253 0550-0034 176 µM -0.774089357628937 0.191134856118489 no 2722 0.219438975253116 3803 5969915 SGTC_1512 0259-0544 12.2 µM -0.775158399014379 0.190810287502618 no 2723 0.219123033460589 3754 18476 SGTC_1541 2',3',6-trimethoxyflavone 64 µM -0.776244723866616 0.190480818158542 no 2724 0.218802251842524 3858 688801 SGTC_2207 7258803 200 µM -0.776812413389107 0.19030878376596 no 2725 0.218634725969281 3747 3666799 SGTC_2987 9018338 71.43 µM -0.777620652443618 0.190064017228914 no 2726 0.218396341077256 3850 5055682 SGTC_2610 ononetin 44.17 µM -0.77807456793894 0.189926638665124 no 2727 0.218262527307131 3810 259632 SGTC_1761 st044296 37 µM -0.778090907728012 0.189921694529106 no 2728 0.218257711236981 3793 1826700 SGTC_236 1509-0011 5.31 µM -0.779037526020486 0.189635399383005 no 2729 0.217978804827997 3863 3107280 SGTC_1959 st077091 55.8 µM -0.779988705006371 0.189347992462826 no 2730 0.217698761773813 3805 821356 YKL052C ASK1 SGTC_2390 9097792 176.6 µM -0.780041034506438 0.189332188438859 no 2731 0.217683361117363 3822 4497149 SGTC_1633 st005664 67.9 µM -0.780821080606636 0.189096703113923 no 2732 0.217453866824879 3814 2063822 SGTC_771 0250-0039 27.3 µM -0.782477136881177 0.188597360540645 no 2733 0.21696710834072 3777 3005115 SGTC_1261 0712-0010 12.7 µM -0.783191800506572 0.188382122852054 no 2734 0.216757244585842 3781 2840123 SGTC_174 3553-0389 74.3 µM -0.784109150703663 0.188106063526352 no 2735 0.216488033248189 3796 738071 SGTC_1471 k673-0312 37 µM -0.784649601194246 0.187943542035517 no 2736 0.216329519870275 3790 24099884 SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM -0.786794060984775 0.187299525999023 no 2737 0.215701215352858 3800 6708760 SGTC_529 4076-0302 30.3 µM -0.787724471283216 0.187020533616001 no 2738 0.215428944175018 3786 5816522 SGTC_618 k072-0232 33.2 µM -0.787892512008239 0.186970172428444 no 2739 0.215379790740744 3848 5872756 YGL099W LSG1 SGTC_675 1309-0189 238 µM -0.788291566065489 0.186850611019765 no 2740 0.215263089890752 3845 4246530 SGTC_1834 st055981 52.8 µM -0.788856035905036 0.186681569868756 no 2741 0.215098076917675 3871 471719 YDL150W RPC53 SGTC_644 1498-1197 63.3 µM -0.789514069945085 0.186484628710214 no 2742 0.214905804809517 3880 6741615 SGTC_1750 st081859 2.357 µM -0.790507480333323 0.186187557577211 no 2743 0.214615727695279 3801 5291695 SGTC_129 0088-0017 176.636 µM -0.790534658905026 0.18617943417476 no 2744 0.214607794716941 3691 182446 SGTC_574 1315-0397 40 µM -0.79106502335453 0.186020957529171 no 2745 0.21445302416984 3831 6794277 SGTC_3102 9121669 49.47 µM -0.792724494376135 0.185525636301858 no 2746 0.213969178042074 3828 41905072 SGTC_2940 9060638 45.86 µM -0.792796034764432 0.185504301247369 no 2747 0.213948333561143 3834 4027022 SGTC_1012 4112-3522 18 µM -0.793025183094251 0.18543597398667 no 2748 0.213881575345437 3790 3112398 SGTC_1772 st048439 82.2 µM -0.79348687053562 0.185298355858578 no 2749 0.213747107913262 3859 2927068 YDL195W SEC31 SGTC_829 1635-0120 117 µM -0.79530644147534 0.184756602417962 no 2750 0.213217633735185 3850 285054 SGTC_3158 9100007 49.47 µM -0.796067427498947 0.184530321090514 no 2751 0.21299642260162 3846 19297233 SGTC_1655 st012546 55.1 µM -0.797586672827385 0.184079085049821 no 2752 0.212555193716869 3789 720985 YLR208W SEC13 SGTC_2878 9043973 25.97 µM -0.79762708074861 0.184067092746157 no 2753 0.212543465484742 3922 6465167 SGTC_1832 st054113 55 µM -0.798508383828708 0.183805659724428 no 2754 0.212287764946458 3784 1251267 SGTC_2604 4'-hydroxychalcone 11.32 µM -0.800213813037753 0.183300412107185 no 2755 0.211793464050077 3845 5282362 SGTC_3308 9128332 17.569 µM -0.800252696218268 0.183288902747705 no 2756 0.211782202023175 3837 17332805 YDL196W YDL196W SGTC_1587 estradiol valerate 56.1 µM -0.800801522336132 0.183126499164347 no 2757 0.211623278785762 3839 13791 A steroid. SGTC_595 3909-8003 73.7 µM -0.801633281593453 0.182880543769261 no 2758 0.211382559891551 3920 699517 SGTC_975 1335-0046 28.5 µM -0.801917638489782 0.182796505317885 no 2759 0.211300301151349 3834 16486740 SGTC_711 k292-0785 179 µM -0.804317988259179 0.182088070130807 no 2760 0.210606675773455 3812 4146315 SGTC_2757 clomiphene 4.22 µM -0.804651958966997 0.181989638777534 no 2761 0.21051027475979 3878 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined. SGTC_791 1348-1292 225 µM -0.805714678852913 0.181676644254511 no 2762 0.210203691859585 3813 5437054 SGTC_1574 spiramycin 23.7 µM -0.807149572820196 0.181254570999702 no 2763 0.209790157218986 3816 6419898 An antibiotic and protein synthesis inhibitor. SGTC_1177 0983-0204 23.6 µM -0.807214226063439 0.181235567753943 no 2764 0.209771535502969 3890 766818 SGTC_3047 9092122 49.47 µM -0.807384444419662 0.181185542182471 no 2765 0.209722513098912 3827 17173831 SGTC_1153 4055-0057 267 µM -0.808332651769766 0.180907031280466 no 2766 0.209449555371379 3875 882706 SGTC_2000 st075254 36.4 µM -0.808531536400928 0.180848648223841 no 2767 0.209392329553702 3793 17234175 SGTC_3070 9117005 49.47 µM -0.810120468238816 0.180382637669582 no 2768 0.208935470735759 3875 8779016 SGTC_2323 6148992 148.28 µM -0.810999829161502 0.180125058078382 no 2769 0.208682884429359 3833 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42 SGTC_2750 bromebric acid 70.15 µM -0.812221981633667 0.17976745274621 no 2770 0.208332134253886 3933 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2 SGTC_5 0352-0601 109.883 µM -0.814391128755065 0.179133853236476 no 2771 0.207710459556279 3765 762456 SGTC_1950 st077106 7.18 µM -0.815560399064996 0.178792897329632 no 2772 0.207375803312742 3874 13831864 SGTC_907 3448-6986 75.5 µM -0.81558753705315 0.178784988823143 no 2773 0.207368039950326 3865 590582 SGTC_635 k038-0028 24.7 µM -0.815621113582432 0.178775204312704 no 2774 0.207358434952704 3855 4035102 SGTC_3225 9130819 49.47 µM -0.817484010181833 0.178232867323145 no 2775 0.206825941691594 3807 4547121 SGTC_1641 st009299 47.1 µM -0.817546371378933 0.178214730333444 no 2776 0.206808130283364 3774 4046054 SGTC_1167 k781-0610 148 µM -0.819625935175145 0.177610580969715 no 2777 0.206214692012776 3873 4525169 SGTC_1064 honokiol 6.76 µM -0.819671663696891 0.177597310579869 no 2778 0.206201653968049 3865 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis. SGTC_357 1325-0123 420 µM -0.819695295099406 0.177590453006133 no 2779 0.206194916410983 3895 1098503 SGTC_3355 9151058 44.0485 µM -0.820086299483673 0.177477012081341 no 2780 0.206083455965621 3856 17015728 SGTC_2367 9070478 135.38 µM -0.822767736139911 0.176700287836294 no 2781 0.205320043711518 3824 572802 SGTC_3008 9078912 71.4286 µM -0.823148385591129 0.176590200639355 no 2782 0.205211808108996 3851 16648731 SGTC_2418 pentamidine 31.67 µM -0.824801877893032 0.176112499571214 no 2783 0.204742040183071 3840 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_1486 3970-0793 4.53 µM -0.829064552646262 0.174884771404602 no 2784 0.203533940281885 3908 2844330 SGTC_2453 5731132 22.18 µM -0.829150142624508 0.1748601756847 no 2785 0.203509726543608 3908 1362040 SGTC_1822 st052468 42 µM -0.829546145977539 0.174746406038987 no 2786 0.203397718020118 3882 2873678 SGTC_885 0865-0106 16.8 µM -0.830078755605343 0.174593464259884 no 2787 0.203247128780674 3808 2793380 SGTC_1407 3909-7909 12.3 µM -0.831935062398804 0.174061080224338 no 2788 0.202722799765491 3855 4411780 SGTC_2319 6033012 152.6 µM -0.832148503455792 0.173999932096449 no 2789 0.202662563450059 3845 847246 SGTC_1992 st073643 23.3 µM -0.832485687447474 0.173903361037096 no 2790 0.202567426794039 3825 3161292 SGTC_976 1348-1067 47.6 µM -0.833781512503186 0.173532547994327 no 2791 0.202202057528853 3915 5310671 YGL099W LSG1 SGTC_1348 1493-0373 93.8 µM -0.83484281099083 0.17322922213943 no 2792 0.201903108978354 3888 3010129 SGTC_1549 4'-methoxyflavonol 74.6 µM -0.834895980692386 0.173214034786982 no 2793 0.201888139000378 3823 97141 SGTC_248 streptozotocin 5.23457 mM -0.835095615003996 0.173157018965447 no 2794 0.201831937709498 3873 5300 DNA alkylating agent. SGTC_2203 7227154 166.4 µM -0.835110626464731 0.173152732155792 no 2795 0.201827712043783 3870 896304 SGTC_2669 eugenol 100 µM -0.838339457820388 0.172232248671255 no 2796 0.200920040588436 3848 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism. SGTC_179 1273-0063 6.77 µM -0.84105462691721 0.171460622757739 no 2797 0.200158666107361 3883 3108139 SGTC_497 capsazepine 133 µM -0.844336863249703 0.170530796133732 no 2798 0.199240596185771 3876 2733484 A calcium channel blocker. SGTC_2051 5263410 176 µM -0.844408269886254 0.170510603257771 no 2799 0.199220651359696 3930 227584 SGTC_3099 9120367 49.47 µM -0.847693786749082 0.169583157646521 no 2800 0.198304263753046 3920 24824940 SGTC_2459 5811157 9.22 µM -0.848029617750337 0.169488540904994 no 2801 0.198210738190665 3872 2870684 YBR192W RIM2 SGTC_392 N-ethylmaleimide 8.33 µM -0.848299190948002 0.169412616094086 no 2802 0.1981356840299 3847 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides. SGTC_121 0557-0495 61.343 µM -0.848879060424745 0.169249370876643 no 2803 0.197974295812793 4039 3104427 SGTC_3184 9108758 49.47 µM -0.849620577434464 0.169040765731503 no 2804 0.19776803386879 3915 902885 SGTC_3046 9092212 49.47 µM -0.850891346111511 0.168683654537876 no 2805 0.197414856249294 3939 25236637 SGTC_1477 0139-0234 16 µM -0.851507137325233 0.168510779537202 no 2806 0.197243850127605 3917 620880 SGTC_2417 cerulenin 830 nM -0.851867988362775 0.168409528472692 no 2807 0.197143682921797 3939 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1 SGTC_740 k014-0057 261 µM -0.85210815604046 0.168342161598224 no 2808 0.197077032793939 3913 4012779 SGTC_1843 st055809 45.5 µM -0.853495486134038 0.167953355708865 no 2809 0.196692294881739 3974 16413835 SGTC_3065 9113888 49.47 µM -0.854177425119575 0.167762451106179 no 2810 0.196503344716391 3971 16648368 SGTC_1308 1187-1617 41.4 µM -0.854373389756822 0.167707617872528 no 2811 0.196449067613983 3894 2882570 SGTC_387 norethindrone acetate 66.7 µM -0.855023861524978 0.167525690892393 no 2812 0.196268969012217 3911 541197 SGTC_3131 9127911 49.47 µM -0.855593688844994 0.167366423439344 no 2813 0.196111281030654 3943 45595681 SGTC_1048 3161-0300 24.5 µM -0.855600552578183 0.167364505612219 no 2814 0.196109382102228 3898 2165101 SGTC_3352 9151559 45.5865 µM -0.85598060220353 0.167258336307949 no 2815 0.196004254534211 3902 17159339 SGTC_2565 isoliquiritigenin 100 µM -0.85600811639215 0.167250651728139 no 2816 0.195996645014046 4004 638278 Binds to benzodiazepine receptor 65X better than valium. SGTC_710 3448-4187 58 µM -0.857595417768816 0.166807711422296 no 2817 0.195557953084932 3897 3946412 SGTC_2172 5754775 163.918 µM -0.857626315790277 0.166799096770363 no 2818 0.195549419535225 3892 2263357 SGTC_508 roscovitine 141 µM -0.859508264022463 0.166274933524787 no 2819 0.195030081316214 3972 160355 A CDKinase inhibitor. SGTC_3036 9090181 49.47 µM -0.862502442855903 0.165443185187927 no 2820 0.194205544697172 3942 25236586 SGTC_1467 k284-1082 293 µM -0.862527296691071 0.165436292362213 no 2821 0.19419870934776 3861 3334705 SGTC_201 4262-0159 12.803 µM -0.863062788007797 0.165287827274255 no 2822 0.194051473089497 3952 1341029 SGTC_1363 1636-0063 10.4 µM -0.863826734180198 0.165076172314202 no 2823 0.193841539683823 3917 6072185 SGTC_3083 9117465 49.47 µM -0.86389489367701 0.165057296927406 no 2824 0.193822816094053 3888 16420915 SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM -0.863898276157203 0.165056360254683 no 2825 0.193821886946723 3908 7104 SGTC_1611 st001856 99.4 µM -0.864105205323919 0.16499906420081 no 2826 0.193765049890729 3904 647478 SGTC_191 3914-0123 66.505 µM -0.864945935330583 0.164766409225915 no 2827 0.193534231826731 3873 3144412 SGTC_1701 st028638 40.4 µM -0.865065113487988 0.164733446294151 no 2828 0.193501525658775 3874 3490878 SGTC_1875 nocodazole 6 µM -0.86565412331569 0.164570597545837 no 2829 0.193339932679914 3895 4122 A microtubule depolymerizer. YJL014W CCT3 SGTC_2556 citropten 84.59 µM -0.866443375806749 0.164352549553692 no 2830 0.193123532900925 3975 2775 A potential DNA crosslinker. SGTC_1506 4226-2149 212 µM -0.867332674661289 0.16410708612819 no 2831 0.192879879340312 3950 991114 SGTC_3180 9109287 49.47 µM -0.86818035924532 0.163873330515742 no 2832 0.192647802300002 3989 18891271 SGTC_670 4204-0025 119 µM -0.86898972874028 0.163650342334969 no 2833 0.192426374403225 3940 719039 SGTC_551 k048-0028 34.9 µM -0.870120404866473 0.163339161429679 no 2834 0.192117303867674 3923 6836383 SGTC_930 2810-3379 265 µM -0.870193673940723 0.163319009830334 no 2835 0.192097286236509 3966 1015764 SGTC_3043 9092303 49.47 µM -0.873499514796294 0.162411466727724 no 2836 0.191195435293578 3947 25236084 SGTC_2606 farnesol 9.78 µM -0.874510056920373 0.162134701739979 no 2837 0.190920272886031 3986 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_2152 5568786 200 µM -0.875636180397582 0.161826643635442 no 2838 0.190613924970283 3891 5399883 SGTC_2305 7443522 69.23 µM -0.878812351905953 0.160959838290263 no 2839 0.189751513944011 3858 5415886 SGTC_664 1222-0054 14.9 µM -0.878872444780079 0.160943467677104 no 2840 0.189735220370714 3907 6813991 SGTC_2212 7123476 200 µM -0.879105303329212 0.160880042181026 no 2841 0.189672091264787 3898 1085715 SGTC_2023 5144124 124 µM -0.880221796130181 0.160576161054628 no 2842 0.189369584058964 3942 2830192 SGTC_1148 3909-7663 27.7 µM -0.881097206381321 0.16033815891419 no 2843 0.189132604588238 3995 4084526 SGTC_902 1120-0002 2.07 µM -0.881472556309291 0.160236181312022 no 2844 0.189031050791361 3920 3280475 SGTC_2571 chrysanthemic acid 100 µM -0.882530481871007 0.159948985142197 no 2845 0.188745001721513 3973 2743 An insecticide. SGTC_1292 0kpi-0043 232 µM -0.884863337957378 0.159316872662533 no 2846 0.188115171756056 3974 3333905 SGTC_2253 7938677 135.83 µM -0.885179189967037 0.159231415062488 no 2847 0.188029997099861 4037 2301972 SGTC_2923 7992654 58.14 µM -0.886924903283266 0.158759632726448 no 2848 0.187559666499168 3963 2985126 SGTC_1121 fusaric acid 630.51 nM -0.888503954212953 0.158333681316483 no 2849 0.187134864889397 3941 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler. SGTC_1200 1643-0193 18.4 µM -0.888760613926161 0.158264517871862 no 2850 0.187065873691311 3936 5403974 SGTC_1431 4049-0260 9.09 µM -0.888847202723661 0.158241188805535 no 2851 0.187042601812328 3933 3854841 SGTC_2261 9010538 184.68 µM -0.890617595074062 0.157764698075097 no 2852 0.186567178288133 3961 6457250 SGTC_1018 4259-0013 28.1 µM -0.890937961677631 0.157678574083099 no 2853 0.18648122663916 4027 6801262 SGTC_1935 st074532 41.6 µM -0.891263512752944 0.157591087997873 no 2854 0.186393909168346 3959 2829742 SGTC_2941 9056145 11.23 µM -0.893176353439662 0.15707769030524 no 2855 0.185881369598301 3812 2119517 SGTC_2026 5148700 152 µM -0.896223630493332 0.156262089693725 no 2856 0.185066668697217 3940 79838 SGTC_2762 leflunomide 42.06 µM -0.896533298075177 0.156179363913414 no 2857 0.184984002258843 3933 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1 SGTC_2237 6667747 47.222 µM -0.898158652367921 0.155745633831047 no 2858 0.184550486718969 3955 729940 YDL015C TSC13 SGTC_928 2764-0428 58.7 µM -0.900502731336247 0.155121510274087 no 2859 0.183926386217121 4010 662578 SGTC_2942 9052777 62.25 µM -0.902594216554737 0.154566036995313 no 2860 0.183370648566955 4028 6469503 SGTC_168 3970-0862 530.542 µM -0.905328640408875 0.153841792327183 no 2861 0.182645653889215 3957 3135186 SGTC_265 mycophenolic acid 32.932 µM -0.905744467584623 0.153731852627151 no 2862 0.182535560062626 4048 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1 SGTC_724 3910-0327 137 µM -0.907010147493171 0.153397542248833 no 2863 0.182200715551911 4024 2885483 SGTC_2365 9042475 200 µM -0.907618566338002 0.153237009050553 no 2864 0.182039890791547 4060 6464479 SGTC_1250 0485-0349 40.2 µM -0.908113210184267 0.153106577810876 no 2865 0.181909205872157 3985 6842794 YDL195W SEC31 SGTC_2075 5212009 200 µM -0.910422996868286 0.152498490987224 no 2866 0.181299737143586 3869 780898 SGTC_627 1391-0720 175 µM -0.910473471930574 0.152485220569963 no 2867 0.181286432902391 3959 997839 SGTC_707 0865-0008 204 µM -0.911571830808634 0.15219664040324 no 2868 0.180997078356583 3988 723043 SGTC_282 k297-0036 65.7 µM -0.913538363716978 0.151680864680196 no 2869 0.180479733149688 3992 5061378 SGTC_2088 5278280 127.392 µM -0.913754782887118 0.151624174020364 no 2870 0.180422855437346 4047 791502 SGTC_1741 st038134 10.228 µM -0.914116595380449 0.151529429267443 no 2871 0.180327791627628 4057 1272587 SGTC_138 0850-0259 40.9225 µM -0.914513381213605 0.151425571603582 no 2872 0.18022357494809 3968 6813004 SGTC_1551 6-bromo-3'-methylflavone 63.5 µM -0.914666658752207 0.15138546428215 no 2873 0.180183326386344 3991 688751 SGTC_2644 guaiazulene 100 µM -0.915979456988429 0.151042240702886 no 2874 0.179838834857215 4004 3515 A coloring agent. SGTC_2082 5219693 150 µM -0.917642591992083 0.15060816768525 no 2875 0.179403005895041 3976 2834649 SGTC_2240 6690706 185.951 µM -0.918619286024077 0.150353641199911 no 2876 0.179147370374518 3850 805876 SGTC_869 0564-0080 44.1 µM -0.920306378287258 0.149914660430883 no 2877 0.178706338447216 4024 6843321 SGTC_2387 9077560 195.08 µM -0.922849981358821 0.149254433189476 no 2878 0.178042694924213 3975 5303272 SGTC_2654 protoveratrine a 100 µM -0.923280622721019 0.149142846760622 no 2879 0.17793049163288 3982 5702278 A heart drug and vasodilator. SGTC_1849 st056239 19.2 µM -0.924056921858232 0.148941835363103 no 2880 0.177728340137253 4017 5393181 SGTC_2311 7694451 200 µM -0.924762627175855 0.148759260348185 no 2881 0.177544697349208 3972 2163142 SGTC_3157 9099274 49.47 µM -0.927587111113585 0.148030028047561 no 2882 0.17681089300989 3993 17217662 SGTC_396 dithiazanine 1.25 µM -0.929626588413229 0.147504960699722 no 2883 0.176282228025948 3998 10578 An antihelmenthic. SGTC_1683 st010134 710 nM -0.929881845830309 0.147439332152435 no 2884 0.176216131741843 4001 3818134 SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM -0.930510734142317 0.147277723865241 no 2885 0.17605335451294 4059 688788 SGTC_1303 1160-0052 261 µM -0.935591767901689 0.145976383106469 no 2886 0.174741707320849 3974 3562476 SGTC_916 4466-0038 42 nM -0.940743491528252 0.144664848416447 no 2887 0.173418162738911 4093 5722064 YGL116W CDC20 SGTC_158 k038-0087 26.446 µM -0.941912664344562 0.144368306900519 no 2888 0.173118677848082 3938 X158 SGTC_1788 fluconazole 20 µM -0.94298951676778 0.144095543614447 no 2889 0.172843132539559 4074 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11 SGTC_512 prima-1 270 µM -0.94340061884507 0.143991504482828 no 2890 0.172738013381545 4040 322968 A re-activator of the apoptotic function of mutant p53. SGTC_1805 st050013 60.3 µM -0.944422042617157 0.143733228329385 no 2891 0.172477010890925 3953 4037144 SGTC_731 3966-0296 387 µM -0.946355952874499 0.143245078481259 no 2892 0.171983531772858 4022 660956 SGTC_342 k048-0088 23.3 µM -0.948333377038076 0.142747104085422 no 2893 0.171479882145634 4012 6820570 SGTC_3026 9090633 49.47 µM -0.950080797305384 0.142308026672923 no 2894 0.171035599809124 4031 25236842 SGTC_1076 itraconazole 331 nM -0.951130260209817 0.142044765897367 no 2895 0.170769127636718 4028 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1 SGTC_2812 7970281 58.44 µM -0.952478051061744 0.141707152544648 no 2896 0.170427296108066 4096 2233435 SGTC_2258 7960471 200 µM -0.954172003405977 0.141283599293921 no 2897 0.169998291828378 4062 2974708 SGTC_1489 4065-0444 182 µM -0.954914079559554 0.141098322303748 no 2898 0.169810574524851 4006 2877968 SGTC_1631 benzylvanillin 81.9 µM -0.955347946703622 0.14099007339518 no 2899 0.169700884085855 4118 75506 SGTC_2408 sulbentine 18.36 µM -0.956166343951063 0.140786038430659 no 2900 0.169494100357766 4022 67686 An antifungal agent of unknown mechanism. YDL205C HEM3 SGTC_2809 7964133 12.99 µM -0.957307759922797 0.140501806247507 no 2901 0.169205969881528 4056 1253665 SGTC_1155 4088-0394 48.2 µM -0.957495343215536 0.140455132083486 no 2902 0.169158647868643 4022 2326248 SGTC_2830 7992007 71.43 µM -0.960920599236235 0.139604716494796 no 2903 0.168296046250445 3926 1952075 SGTC_71 0417-1750 47.813 µM -0.966028379129535 0.13834308306288 no 2904 0.167014990311893 4070 6811472 SGTC_1251 0490-5699 265 µM -0.966881517139169 0.138133115833441 no 2905 0.166801633655393 4109 3883818 SGTC_1067 clotrimazole 1.36 µM -0.967096872453711 0.138080148742275 no 2906 0.166747804421254 4078 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_1963 st076565 50.3 µM -0.967981653327471 0.137862680391458 no 2907 0.166526766259071 4061 4914280 SGTC_3257 9139206 32.98 µM -0.968277728574902 0.137789960912052 no 2908 0.166452842257947 4055 4910041 SGTC_208 k072-0098 12.366 µM -0.969441339820565 0.137504418220027 no 2909 0.166162517353516 4025 5948901 SGTC_1395 3486-0190 4.35 µM -0.969643947467436 0.137454740933423 no 2910 0.166111999524058 4033 6748079 SGTC_1406 3909-7906 11.9 µM -0.97165094044485 0.136963309016418 no 2911 0.16561211552151 4061 X1406 SGTC_1941 st076221 61.8 µM -0.971912698653586 0.136899303571663 no 2912 0.165546990897645 3983 2828568 SGTC_409 arachidonic acid 100 µM -0.972539131160306 0.136746210523483 no 2913 0.165391203710813 4056 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes. SGTC_3240 9133527 49.47 µM -0.973658191988358 0.136473016052852 no 2914 0.16511314117772 3984 17617455 SGTC_379 3970-0972 5.9 µM -0.974137832370616 0.136356036611087 no 2915 0.164994053570579 4053 2898042 YBL034C STU1 SGTC_1898 st060199 18.6 µM -0.975036545609401 0.136137034267972 no 2916 0.164771066146361 4030 688866 SGTC_3002 9075603 71.4286 µM -0.97528839807037 0.136075704975775 no 2917 0.164708611915195 3998 20105405 SGTC_1449 4112-4002 201 µM -0.978305036462797 0.135342584781139 no 2918 0.163961739845809 4122 2059539 SGTC_2729 fluphenazine 10.66 µM -0.978399885185206 0.135319578101346 no 2919 0.163938292485432 4002 3372 An atypical antipsychotic. SGTC_2116 5511452 16.8835 µM -0.979842098379724 0.134970082493 no 2920 0.16358203396145 4103 870744 SGTC_1016 4226-1401 38 µM -0.985991736157263 0.133486775081948 no 2921 0.162068584037897 4038 2901613 SGTC_1304 1165-0502 251 µM -0.986585292603622 0.133344203441968 no 2922 0.161922991589834 4078 767425 SGTC_905 2-aminofluorene 215 µM -0.98664105001194 0.133330815955244 no 2923 0.161909319329623 4073 1539 An established DNA mutagen. YPR165W RHO1 SGTC_1826 st055655 41.6 µM -0.986989658592967 0.13324713516775 no 2924 0.161823854158011 4098 676168 SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM -0.989492763244984 0.132647345634711 no 2925 0.16121105440437 4071 66535 A nucleotide analog. SGTC_2171 5739187 198.077 µM -0.992379276975034 0.131957996357717 no 2926 0.160506272010713 4016 2262761 SGTC_579 4491-1009 110 µM -0.996625850939006 0.130948339469371 no 2927 0.159473076625825 4199 1271041 SGTC_972 1319-0219 195 µM -1.00315460375646 0.129406511108843 no 2928 0.15789313616178 4075 23903702 SGTC_2405 ticlatone 3.52 µM -1.00340114155849 0.129348536336582 no 2929 0.157833676771766 3943 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W SGTC_1937 st074714 47.2 µM -1.0052995408666 0.128902719828228 no 2930 0.157376318062498 4056 17250970 SGTC_2173 5763948 167 µM -1.00617340794573 0.128697861146915 no 2931 0.157166080777811 4075 2867177 SGTC_598 3937-0236 20.2 µM -1.00682467325381 0.128545333480355 no 2932 0.157009517790141 4165 1379313 SGTC_1786 berberine 21.6 µM -1.00833906313121 0.12819114546627 no 2933 0.156645858005376 4011 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_2735 sertaconazole 140 nM -1.00896637443724 0.12804462756586 no 2934 0.156495380405995 4230 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C SGTC_1776 st049249 45.9 µM -1.01399420949893 0.126874504216774 no 2935 0.155292757667974 4125 1822314 SGTC_261 5-fluorouridine 15.376 µM -1.01471324027888 0.126707775216355 no 2936 0.155121270422401 4116 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_226 1,3-diallylurea 8.28947 mM -1.01682086061502 0.126219939092923 no 2937 0.154619328254566 4052 74537 YKL182W FAS1 SGTC_141 0443-0274 32.331 µM -1.01727581184581 0.126114806733559 no 2938 0.154511119958587 4112 1627241 SGTC_209 4077-0173 175.592 µM -1.01772175701731 0.126011814797614 no 2939 0.154405102308604 4085 15993494 SGTC_2419 paclitaxel 166.5 µM -1.01798700425588 0.125950583235213 no 2940 0.154342066051932 4032 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_3243 9134147 49.47 µM -1.02058034624347 0.12535301067592 no 2941 0.153726652466753 4174 24282180 SGTC_2254 7938975 95.19 µM -1.02094823512425 0.125268400198453 no 2942 0.153639482266122 4203 2969277 SGTC_92 0063-0024 660.874 µM -1.02099714643791 0.125257154127204 no 2943 0.153627895337937 4191 3594437 SGTC_2208 7283366 200 µM -1.02203483645867 0.125018726442951 no 2944 0.153382206365517 4091 898663 SGTC_175 3793-3120 23.7 µM -1.02513290719267 0.124308776502205 no 2945 0.152650240144008 4121 5322297 SGTC_2695 st077686 51.995 µM -1.02538937921927 0.124250130330455 no 2946 0.15258974876485 4152 2876092 SGTC_2875 9039966 71.43 µM -1.02540950187988 0.124245529801514 no 2947 0.152585003315942 4129 6463691 SGTC_637 1181-0519 7.26 µM -1.0254794122146 0.124229547527122 no 2948 0.152568517394216 4100 6252091 YGR060W ERG25 SGTC_1158 4092-0494 91.8 µM -1.02810617269905 0.12363008295585 no 2949 0.151949943675615 4217 1148199 SGTC_2686 alizarin 95.37 µM -1.02979896379162 0.12324483863912 no 2950 0.151552193638848 4116 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1 SGTC_144 4161-2749 112.381 µM -1.02993372099105 0.123214206870271 no 2951 0.151520559915007 4061 797501 YMR168C CEP3 SGTC_118 0083-0097 135.343 µM -1.03187452145533 0.122773633614219 no 2952 0.151065451529505 4142 5207356 SGTC_2133 5320837 200 µM -1.03598850762342 0.121843390492131 no 2953 0.150103752026301 4175 2841355 SGTC_88 0180-0332 8.668 µM -1.03713553359506 0.121584913201139 no 2954 0.149836348508658 4214 3101745 SGTC_47 0149-0135 24.25 µM -1.04033444699114 0.120866089003234 no 2955 0.149092272808012 4164 5239155 SGTC_1712 st032288 53.4 µM -1.0407347350558 0.120776351703587 no 2956 0.148999338786122 4015 2883011 SGTC_1342 1486-1464 234 µM -1.04119388737372 0.120673475868883 no 2957 0.14889278604107 4166 3253938 SGTC_1711 st032263 62.8 µM -1.04196878011131 0.120499996435497 no 2958 0.148713076794477 4141 3958979 SGTC_2777 climbazole 1.536 µM -1.04248382206771 0.12038478840804 no 2959 0.14859371108105 3994 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2 SGTC_1187 1391-0724 117 µM -1.04251132371344 0.12037863883883 no 2960 0.148587339123566 4171 6997986 SGTC_3130 9127414 49.47 µM -1.04837316407055 0.119072934757723 no 2961 0.147233356331276 4148 1494646 SGTC_3241 9133421 49.47 µM -1.05102043335367 0.118486554250359 no 2962 0.146624602638576 4185 17018221 SGTC_401 neomycin 50 µM -1.05319081811235 0.118007330358807 no 2963 0.146126772912573 4106 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis. SGTC_2904 7225135 42.03 µM -1.05526502171449 0.117550626194726 no 2964 0.145652066855156 4251 4446116 SGTC_408 cantharidin 100 µM -1.05893552800805 0.116745512680691 no 2965 0.144814571327679 4108 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_1573 oleylamine 1.06 µM -1.06108090306401 0.116276745989774 no 2966 0.144326567890442 4139 5356789 An amine of the fatty acid oleic acid. SGTC_328 k915-0120 63.5 µM -1.06255060501245 0.115956386404508 no 2967 0.143992898706949 4140 6624543 SGTC_366 0181-0206 4.31 µM -1.06372144066896 0.115701621297263 no 2968 0.143727454312437 4190 274874 SGTC_2031 5180455 200 µM -1.06996127521849 0.114350584971238 no 2969 0.142318369933324 4120 29949 SGTC_730 1436-0052 41.2 µM -1.0700049430542 0.114341169846533 no 2970 0.142308541875422 4202 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2 SGTC_1479 0549-0158 134 µM -1.07194473662811 0.113923491980482 no 2971 0.141872427395615 4210 5440202 SGTC_1638 st008370 60.6 µM -1.07200740233318 0.113910016903492 no 2972 0.141858353672505 4116 24207134 SGTC_1869 3',7'-dimethoxyflavone 40.3 µM -1.07231078621256 0.113844795985705 no 2973 0.141790231834458 4192 688664 SGTC_1896 st058441 89 µM -1.07472827695808 0.113326038983138 no 2974 0.141248199958863 4175 688759 SGTC_2372 9071633 200 µM -1.07499677048604 0.113268528526134 no 2975 0.141188087113371 4199 21321366 SGTC_254 nsc-64875 3.808 µM -1.07641083481427 0.112965984027016 no 2976 0.140871779410335 4174 56993 SGTC_767 0929-0023 86 µM -1.07747573047896 0.112738526553948 no 2977 0.140633893744345 4175 1204563 SGTC_1989 st071868 50.2 µM -1.08120038942726 0.111945526983619 no 2978 0.139803992419959 4161 16414057 SGTC_2699 st077704 54.6 µM -1.08368583897214 0.111418585260995 no 2979 0.139252058246166 4182 645852 SGTC_1044 1222-0021 1.78 µM -1.08466609724402 0.111211248998676 no 2980 0.139034784342042 4137 4306703 SGTC_2831 7999036 19.48 µM -1.08482971164349 0.111176669529979 no 2981 0.138998541753895 4217 2988270 SGTC_1164 k060-0068 93.7 µM -1.08906978137983 0.110283225565652 no 2982 0.138061557270386 4173 5963676 SGTC_789 1309-1135 70.6 µM -1.0913791848909 0.109798772478039 no 2983 0.1375530338121 4162 3092424 SGTC_2155 5570423 76 µM -1.09297896818008 0.109464076121493 no 2984 0.137201517058055 4138 797402 SGTC_2153 5569715 200 µM -1.09331036357572 0.109394835422076 no 2985 0.137128777086488 4222 2054701 SGTC_1080 nisoldipine 24.4 µM -1.0933618951438 0.109384071407109 no 2986 0.137117468479533 4182 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class. SGTC_1443 4112-3303 14 µM -1.09614783544093 0.108803270638173 no 2987 0.136507041824015 4235 704433 SGTC_1779 st039427 55 µM -1.09640714772638 0.108749323352422 no 2988 0.13645031867673 4160 1124498 SGTC_227 fluconazole 33.516 µM -1.09644362911323 0.108741735314269 no 2989 0.136442339866297 4188 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C SGTC_831 k061-1017 217 µM -1.09772622197002 0.108475201131353 no 2990 0.136162028000097 4219 1240153 SGTC_3254 9136651 49.47 µM -1.09864085743243 0.108285419070668 no 2991 0.135962374470016 4142 16454030 SGTC_854 0422-0053 192 µM -1.10058860087064 0.107882069049588 no 2992 0.135537874475059 4201 3596728 SGTC_2428 5615643 7.78 µM -1.10289637749889 0.10740556320406 no 2993 0.135036083775585 4222 2253075 SGTC_2768 sulfasalazine 50.2 µM -1.10319267537666 0.107344494180066 no 2994 0.134971750748103 4158 5384001 An antioxidant and salicylic acid derivative. SGTC_2573 2',4'-dihydroxychalcone 15.04 µM -1.10623163278131 0.106719588742861 no 2995 0.134313137255521 4184 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_2244 6635614 200 µM -1.10672358690865 0.106618674872887 no 2996 0.134206727145269 4121 836499 SGTC_419 nsc-638432 893 µM -1.10965365787246 0.106019060061405 no 2997 0.133574149825115 4151 368090 SGTC_123 0083-0120 66.675 µM -1.11268044046162 0.105402216573674 no 2998 0.132922849455286 4186 16001701 SGTC_330 1488-0319 80.1 µM -1.11422922402311 0.105087587987884 no 2999 0.132590430608065 4239 6846614 SGTC_3286 9117135 37.221 µM -1.11674625408769 0.104577715309257 no 3000 0.132051417428243 4187 3438150 SGTC_2210 7115885 190.385 µM -1.11876128447462 0.104170825709217 no 3001 0.131620996204526 4286 2927039 SGTC_1419 3993-2473 62.6 µM -1.11988428586688 0.103944559727463 no 3002 0.131381537752007 4275 704026 SGTC_2166 5933061 31.504 µM -1.12618614652505 0.102681450108894 no 3003 0.130043368054393 4364 2877375 SGTC_3122 9126309 49.47 µM -1.13051871330401 0.10181954994295 no 3004 0.129128858868613 4271 17591206 SGTC_2157 5649910 96.377 µM -1.1316488641216 0.101595591633871 no 3005 0.12889104398221 4210 2858091 SGTC_43 0570-0105 72.5 µM -1.13579599504109 0.100776841680816 no 3006 0.128020976802235 4218 1114046 YDL195W SEC31 SGTC_1014 4130-3005 69.3 µM -1.13745250430672 0.100451152685355 no 3007 0.127674584493535 4234 743608 SGTC_1765 st044815 90.4 µM -1.13943180160092 0.100063007699049 no 3008 0.127261549051193 4263 645695 SGTC_576 1073-0113 22.7 µM -1.14032055857867 0.0998890770103304 no 3009 0.127076387914346 4363 5439563 SGTC_3045 9092950 49.47 µM -1.14062978546026 0.0998286127891534 no 3010 0.127012008436771 4182 44120432 SGTC_3089 9117425 49.47 µM -1.14240097938609 0.0994828000621558 no 3011 0.126643692182839 4230 9401657 SGTC_848 0368-0089 85.6 µM -1.14249825744633 0.0994638326245942 no 3012 0.126623484974694 4238 762535 SGTC_2034 5197015 53.07 µM -1.142904955872 0.0993845625167968 no 3013 0.126539027349644 4248 780676 SGTC_462 ag-879 158 µM -1.14543603496366 0.0988922645624243 no 3014 0.126014289136156 4267 6809654 Ag-879 is a 5-Lipoxygenase inhibitor. SGTC_98 0074-0023 107.663 µM -1.14567371484409 0.0988461273376837 no 3015 0.125965091862431 4244 3563821 SGTC_692 k241-0027 77.8 µM -1.14649451171739 0.0986869194829354 no 3016 0.125795298404795 4295 3600480 SGTC_3146 9095609 49.47 µM -1.14952040751305 0.0981016156093428 no 3017 0.125170728361771 4289 17173999 SGTC_2391 6285546 200 µM -1.14984814247779 0.0980383742855109 no 3018 0.125103211339386 4235 846083 SGTC_2041 5107442 45.335 µM -1.1500000807222 0.0980090656839154 no 3019 0.125071919013523 4280 793005 SGTC_22 0964-0034 14.468 µM -1.15315265175123 0.0974023886257179 no 3020 0.124423866886007 4251 138402 SGTC_2533 agelasine 13.65 µM -1.157657455482 0.0965402766895429 no 3021 0.123501926159832 4324 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase. SGTC_1915 st067105 30.6 µM -1.16027070096999 0.0960427401191648 no 3022 0.122969304730995 4191 69751 YOR207C | YOR116C RET1 | RPO31 SGTC_306 1672-3436 11.6 µM -1.16068183956346 0.0959646352811814 no 3023 0.122885654913108 4284 6797378 SGTC_198 3454-2873 16.191 µM -1.16242848504053 0.0956333421857338 no 3024 0.122530729142483 4239 710957 SGTC_2624 nerol 100 µM -1.16394392547591 0.095346585150224 no 3025 0.122223368490996 4158 637566 A natural product oil. SGTC_1242 0402-0103 60.1 µM -1.16411138975854 0.0953149358440652 no 3026 0.122189436733884 4190 432868 SGTC_1236 0330-0013 258 µM -1.16889263313264 0.0944145821214234 no 3027 0.121223445991415 4267 4617066 SGTC_1179 1021-1431 9.29 µM -1.17417899284694 0.0934264277380884 no 3028 0.120161669241343 4273 2840958 SGTC_3143 9086658 49.47 µM -1.17455236860597 0.0933569242888867 no 3029 0.120086924459451 4301 25236626 SGTC_3227 9130768 49.47 µM -1.17470728105745 0.0933280987364979 no 3030 0.120055922699278 4322 17720899 SGTC_2627 acetyl isogambogic acid 100 µM -1.17484467730739 0.0933025380386647 no 3031 0.120028431078674 4277 6857789 A caspase activator and apoptosis inducer. SGTC_2123 5259487 200 µM -1.17546421610073 0.0931873455381716 no 3032 0.119904522651087 4287 2173474 SGTC_2368 9071271 200 µM -1.17878696444526 0.0925713309504184 no 3033 0.119241508157451 4247 27209959 SGTC_1285 0929-0069 65.5 µM -1.18090133887909 0.0921809119852587 no 3034 0.118820959704202 4296 1206237 SGTC_2974 9094440 9.66 µM -1.18117009050318 0.0921313744748751 no 3035 0.118767580223755 4274 25236134 SGTC_1960 st011366 51.8 µM -1.18609641177625 0.0912268213940839 no 3036 0.117792113710117 4285 3972846 SGTC_275 trichlorophene 5.69 µM -1.18666968239762 0.0911219887752884 no 3037 0.117678969070254 4309 62616 SGTC_2897 9048598 12.99 µM -1.18723971268093 0.0910178373213244 no 3038 0.117566540258903 4241 6467404 SGTC_1281 0884-0031 11.8 µM -1.1884536392244 0.0907963325011827 no 3039 0.117327367270449 4292 1548255 SGTC_273 hydroxyurea 18.1 mM -1.18846802996104 0.0907937090289265 no 3040 0.117324534014393 4343 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12 SGTC_825 1988-2224 89.6 µM -1.19539355900746 0.0895376827413113 no 3041 0.115966650505789 4264 1180859 SGTC_2883 9059145 45.46 µM -1.19580808050536 0.089462916297815 no 3042 0.115885730939895 4275 16476510 SGTC_2846 9008642 19.48 µM -1.19680807893601 0.089282739654249 no 3043 0.115690684304939 4312 2992898 SGTC_823 0417-1665 178 µM -1.19725158679676 0.089202916247134 no 3044 0.115604254136562 4277 3429856 SGTC_2732 terfenadine 20 µM -1.20328427131363 0.0881224103348432 no 3045 0.1144331667711 4351 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.  SGTC_2422 chlorphenesin carbamate 384.24 µM -1.20333096585349 0.0881140851629935 no 3046 0.114424135310604 4267 2724 A muscle relaxant with antifungal properties. SGTC_255 tunicamycin 200.472 nM -1.20363849175322 0.0880592710013661 no 3047 0.11436466762697 4211 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_1428 4049-0204 61.7 µM -1.20673686640999 0.0875084269452027 no 3048 0.113766748248895 4334 X1428 SGTC_2344 7990960 76.95 µM -1.20912701905428 0.0870852541325088 no 3049 0.113307025173712 4267 140813 SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM -1.20965505488673 0.0869919726663756 no 3050 0.113205641478864 4196 17037758 SGTC_2386 9075165 157.42 µM -1.21041424472376 0.0868579869468339 no 3051 0.113059989304519 4282 16452277 SGTC_543 3844-1095 191 µM -1.21099570572067 0.086755472036869 no 3052 0.112948525256309 4289 4230703 SGTC_1331 1472-0049 76.2 µM -1.21200903105385 0.0865770330938624 no 3053 0.112754461818755 4258 24051409 SGTC_2227 7312221 64.1025 µM -1.21237052252302 0.0865134436104715 no 3054 0.112685289699203 4404 887188 YOR168W | YOR169C GLN4 | YOR169C SGTC_3056 9094900 49.47 µM -1.21475148709466 0.0860954834108908 no 3055 0.112230444386519 4268 25236784 SGTC_2284 7945075 39.21 µM -1.21531147036757 0.0859974024000721 no 3056 0.11212365936814 4274 1245402 SGTC_756 0508-1999 28.3 µM -1.21560099158412 0.0859467255885838 no 3057 0.112068478123477 4313 6753853 SGTC_1582 3',3',6'-trihydroxyflavone 74 µM -1.21651828594754 0.0857863130596735 no 3058 0.111893774774154 4281 688803 SGTC_86 0417-1630 471.922 µM -1.21717474641435 0.0856716517042128 no 3059 0.111768868177993 4310 3634867 SGTC_1534 6-azauridine 81.6 µM -1.2174645370061 0.0856210716475624 no 3060 0.111713760641891 4324 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1 SGTC_190 3970-0790 3.722 µM -1.21944439949542 0.0852761044596054 no 3061 0.111337783416125 4264 2832352 SGTC_2065 5221596 34.26 µM -1.21957849872127 0.0852527769920921 no 3062 0.111312350674169 4270 788581 SGTC_415 dibenzyl ketone 100 µM -1.22025520528696 0.0851351322409055 no 3063 0.111184072561912 4281 7593 SGTC_279 1273-0055 2.93 µM -1.2210751723373 0.0849927448665725 no 3064 0.111028779526074 4332 2847562 SGTC_1182 1222-0449 220 µM -1.22174842312921 0.0848759682988409 no 3065 0.110901389176122 4307 658318 SGTC_223 busulfan 5 mM -1.22389517219082 0.0845044140745289 no 3066 0.11049588754343 4292 2478 A DNA alkylator. SGTC_2731 amoxapine 43.43 µM -1.2255381313258 0.0842208799001605 no 3067 0.110186266121994 4456 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine. SGTC_187 1488-2104 32.728 µM -1.22570744045706 0.0841917019564199 no 3068 0.11015439462549 4306 2852859 SGTC_9 0092-0002 10.449 µM -1.22589316493199 0.0841597037965645 no 3069 0.110119440638666 4312 759368 SGTC_2774 tamoxifen 10.92 µM -1.22739174233449 0.0839018503237968 no 3070 0.109837694288626 4287 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  SGTC_124 0136-0217 7.121 µM -1.22794864008615 0.0838061787901998 no 3071 0.109733124354099 4361 3976905 SGTC_2189 6047310 154.431 µM -1.22965593367893 0.0835133871507065 no 3072 0.109412987459467 4285 711535 SGTC_1961 st076550 68.7 µM -1.23088024364862 0.0833038983420628 no 3073 0.109183828848503 4329 1579337 SGTC_663 1486-0733 13.9 µM -1.23121993740145 0.0832458442093818 no 3074 0.109120308278447 4318 722445 YPR165W RHO1 SGTC_2239 6685329 187.64 µM -1.23201081349453 0.0831108002470423 no 3075 0.108972522383094 4337 805680 SGTC_2956 9076196 2.52 µM -1.23422550027167 0.082733513902263 no 3076 0.108559443885639 4310 16423868 SGTC_1319 1306-0155 43.7 µM -1.23464951575019 0.0826614273285024 no 3077 0.108480486092105 4362 3122360 SGTC_3113 9123498 49.47 µM -1.23633320288537 0.0823756513377575 no 3078 0.108167367041894 4416 8897275 SGTC_442 cape 100 µM -1.23814558015597 0.0820688645602763 no 3079 0.107831042848817 4321 5281787 SGTC_2964 9083345 53.42 µM -1.24610656932799 0.080731471287892 no 3080 0.106362636688962 4296 17741579 SGTC_1482 3346-2049 8.48 µM -1.2483763748054 0.0803531906216159 no 3081 0.105946628329351 4339 3826804 SGTC_2540 epiandrosterone 100 µM -1.25050637368695 0.0799994293972555 no 3082 0.105557314244994 4364 441302 A steroid. SGTC_3294 9122953 26.2835 µM -1.25063992518424 0.0799772877689796 no 3083 0.105532938659981 4301 16459826 SGTC_1127 asiatic acid 681.4 nM -1.25171418076538 0.0797993544369011 no 3084 0.105337015468336 4270 470603 A kinase inhibitor which arrests cells at G2/M. SGTC_3320 9137005 35.139 µM -1.25235308388978 0.0796936723920532 no 3085 0.105220616903449 4369 4908713 SGTC_2996 9066192 71.4286 µM -1.25315117354799 0.0795618078118534 no 3086 0.105075347717132 4344 6472854 SGTC_655 k060-0012 42 µM -1.25412982573748 0.0794003351693148 no 3087 0.104897410540692 4304 5994525 SGTC_2868 9035608 32.47 µM -1.25424379085672 0.0793815476389426 no 3088 0.104876703751599 4313 6462614 SGTC_94 0334-0113 514.748 µM -1.2550622773021 0.0792467162642985 no 3089 0.104728076545066 4339 6795178 SGTC_2039 Aminomethylbenzodioxan 200 µM -1.25579557777237 0.0791260651126481 no 3090 0.104595047682021 4319 15053 SGTC_950 1165-0508 94.1 µM -1.25621326697288 0.0790574042183644 no 3091 0.104519328953601 4327 6148369 SGTC_2714 st079313 56.9 µM -1.25771031910149 0.0788116853432809 no 3092 0.104248269481178 4311 2939799 SGTC_1887 st057648 70.8 µM -1.25811845500823 0.0787447963794645 no 3093 0.104174459985433 4331 688672 SGTC_1488 4013-0813 75.9 µM -1.2582308357992 0.078726385965332 no 3094 0.104154143091124 4283 2910057 SGTC_1515 3460-0031 42.1 µM -1.26053094458629 0.0783502943671128 no 3095 0.103738946059639 4286 2876596 SGTC_1717 st033143 58.0435 µM -1.26437064119979 0.0777255018798915 no 3096 0.103048512695179 4408 674616 SGTC_2107 5363541 170.161 µM -1.2661370070032 0.0774393534473697 no 3097 0.102732017702156 4291 244052 SGTC_1225 1216-0074 20.6 µM -1.26734574637203 0.0772440011592136 no 3098 0.102515844943317 4344 4241466 SGTC_2117 5521686 200 µM -1.26767456177946 0.077190923978673 no 3099 0.102457096362535 4318 803312 SGTC_367 0335-0881 7.1 µM -1.26798200820665 0.0771413212380755 no 3100 0.102402187869282 4284 23828853 SGTC_1455 4262-0120 131 µM -1.26871940574107 0.0770224498318968 no 3101 0.102270579335278 4402 1529587 SGTC_2178 5812956 200 µM -1.27049392027049 0.0767369617220193 no 3102 0.101954373566828 4297 5403383 SGTC_3169 9102970 49.47 µM -1.27288716239885 0.0763532065506338 no 3103 0.101529042663369 4412 17027839 SGTC_2776 terbinafine 19.92 µM -1.27637392048826 0.0757967225515529 no 3104 0.100911685366304 4357 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM -1.27838182155776 0.0754776676959471 no 3105 0.100557415246788 4350 521171 SGTC_1485 3909-9022 254 µM -1.28784048418204 0.0739884411010565 no 3106 0.0989007482305906 4417 714516 SGTC_2127 5253358 187.912 µM -1.28983420350636 0.0736774226630203 no 3107 0.0985541147716579 4262 20612 SGTC_507 nimesulide 162 µM -1.29726043248559 0.0725277275380473 no 3108 0.0972707968223672 4413 4495 A COX2 inhibitor. SGTC_679 0422-0091 41.4 µM -1.30067721220036 0.0720033954035087 no 3109 0.0966844827632795 4394 627384 YHR062C RPP1 SGTC_6 0844-0013 19.835 µM -1.30394281949498 0.0715049828365248 no 3110 0.0961265395922275 4500 1584900 SGTC_2922 7999257 32.47 µM -1.30490254368001 0.0713590096648822 no 3111 0.0959630174899185 4336 2988377 SGTC_443 clozapine 122 µM -1.305312257537 0.0712967622728547 no 3112 0.0958932709498709 4342 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_2718 lomofungin 53.02 µM -1.30565668559184 0.0712444659398595 no 3113 0.0958346670147354 4340 5351222 A RNA synthesis inhibitor. SGTC_3189 9110682 49.47 µM -1.30681400271601 0.0710689600703196 no 3114 0.0956379441617753 4400 17122418 SGTC_294 k038-0071 157 µM -1.31590603932241 0.0697016927190455 no 3115 0.0941027907394893 4380 24152826 SGTC_3201 9113999 49.47 µM -1.32003261367504 0.0690878558471578 no 3116 0.0934120646802313 4360 16649224 SGTC_2122 5258151 111.688 µM -1.32276343465545 0.0686839365245831 no 3117 0.0929570303360191 4387 2173356 SGTC_1613 st002381 52.1 µM -1.32569874896845 0.0682518037138286 no 3118 0.0924697509907352 4373 551167 SGTC_91 0417-1751 58.384 µM -1.33084427481556 0.0674993535830959 no 3119 0.0916201281333563 4489 6795624 SGTC_2040 5100729 123 µM -1.33431070131665 0.0669960696283724 no 3120 0.0910510259569612 4416 11840 YJR013W | YDR381W GPI14 | YRA1 SGTC_1056 3448-1962 115 µM -1.33440996109521 0.0669817011499344 no 3121 0.0910347686387375 4357 715507 SGTC_2979 9012552 45.46 µM -1.3372472264115 0.0665719961286337 no 3122 0.090570975484562 4396 17100905 SGTC_2709 st078560 56 µM -1.33776355633614 0.0664976464376294 no 3123 0.0904867626710135 4374 17250903 SGTC_727 3032-0951 202 µM -1.3397786457153 0.0662080955138637 no 3124 0.0901586600590946 4427 3652836 SGTC_1354 1498-1681 81 µM -1.34278834396117 0.0657774476008616 no 3125 0.089670259364807 4376 5754243 SGTC_3191 9110352 49.47 µM -1.34301482040247 0.0657451298694361 no 3126 0.0896335874914972 4355 17122424 SGTC_1740 st038286 13.222 µM -1.34360802053133 0.0656605397477016 no 3127 0.0895375872679677 4422 716786 SGTC_1804 st050076 49.1 µM -1.34460085942316 0.0655191501139157 no 3128 0.089377082839458 4428 3895976 SGTC_2465 5809242 33.21 µM -1.34507962287148 0.0654510541097036 no 3129 0.0892997614620948 4456 2731748 SGTC_3274 9138298 49.47 µM -1.34738832580468 0.0651234504506239 no 3130 0.0889275992417499 4374 17015756 SGTC_467 ro 31-8220 72.8 µM -1.3509150209089 0.0646254727531156 no 3131 0.0883613279636643 4352 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7 SGTC_478 N-arachidonylglycine 10 µM -1.35140270469009 0.0645568440447431 no 3132 0.0882832339389977 4402 5283389 SGTC_49 0717-0965 32.132 µM -1.35783538428557 0.0636569024365716 no 3133 0.0872579621746616 4471 5889349 YGL099W LSG1 SGTC_426 0988-0037 14.6 µM -1.35829680934928 0.0635927254550467 no 3134 0.0871847611530083 4436 5383008 SGTC_1120 ficusin 1.78878 µM -1.35879845789629 0.0635230111507835 no 3135 0.0871052310655855 4425 6199 A DNA cross-linker. SGTC_2236 dapsone 200 µM -1.36454118253956 0.0627291737628474 no 3136 0.0861986510055313 4424 2955 A bacterial DFR inhibitor. An anti-cancer agent. SGTC_1662 st014054 52 µM -1.36719558638377 0.0623648685300478 no 3137 0.0857820042029216 4481 2838777 SGTC_420 mitomycin C 81.9 mM -1.37104219761453 0.0618398685586831 no 3138 0.0851809010377929 4399 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_795 0685-0265 78 µM -1.37137029996946 0.0617952480687558 no 3139 0.0851297755170596 4420 302754 SGTC_1252 0493-0875 34.8 µM -1.37160382261184 0.0617635053198375 no 3140 0.0850934015935398 4393 3960963 SGTC_3348 9149464 3.537 µM -1.37396165983087 0.0614437170157982 no 3141 0.0847267927385001 4358 1951442 SGTC_1219 1469-0211 33.1 µM -1.37538940300685 0.0612507049125958 no 3142 0.0845053762675598 4423 6822282 SGTC_3179 9107801 49.47 µM -1.3764290347063 0.0611104586998991 no 3143 0.0843444220096885 4409 4818259 SGTC_1916 st067606 49.2 µM -1.3805435408593 0.0605578731075746 no 3144 0.0837096766097699 4329 19590279 SGTC_638 3970-0837 4.09 µM -1.39001373080434 0.0593008651017767 no 3145 0.0822623539385498 4418 4118451 YLR208W SEC13 SGTC_2434 5670830 169.91 µM -1.39354554665477 0.0588373480206459 no 3146 0.0817274409500711 4445 1549830 SGTC_1994 st072947 40.9 µM -1.39405435499465 0.0587708067274171 no 3147 0.0816505956947443 4477 5286565 YDL195W SEC31 SGTC_1287 0971-0001 34.6 µM -1.40003222236012 0.0579934449390251 no 3148 0.0807518347702734 4409 4665869 SGTC_481 bay k-8644 50 µM -1.4013326454866 0.0578254129065536 no 3149 0.0805573116810601 4398 2303 A calcium channel antagonist. SGTC_1337 1486-1011 40.3 µM -1.4056126231744 0.0572750843769829 no 3150 0.0799195927975874 4416 X1337 SGTC_2085 5307070 144.047 µM -1.40787562126083 0.0569857736609384 no 3151 0.0795839515201298 4387 2840351 SGTC_321 4534-3890 65.3 µM -1.41504012239302 0.0560774180349276 no 3152 0.0785283662620412 4444 699746 SGTC_1300 1094-0077 113 µM -1.41754116604458 0.0557630241578643 no 3153 0.0781623837617386 4419 5532636 SGTC_2833 9001315 45.46 µM -1.42016082744881 0.0554352125078963 no 3154 0.0777804324919818 4393 2989378 SGTC_2163 5671233 125 µM -1.42599803596016 0.0547102455634413 no 3155 0.0769344544918828 4411 701023 SGTC_1065 prochlorperazine maleate 2.48 µM -1.42870934564636 0.0543760668430708 no 3156 0.0765438952828686 4486 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine. SGTC_50 0929-0078 56.389 µM -1.43163314522053 0.0540175096778866 no 3157 0.0761244193232849 4307 1377751 SGTC_801 0866-0028 10.1 µM -1.43262161026404 0.0538967144853414 no 3158 0.0759830012763969 4486 6849771 SGTC_264 promethazine 12.5 mM -1.43449093567516 0.0536688586762853 no 3159 0.0757161069687343 4327 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3 SGTC_521 r062-0005 13.8 µM -1.43467147997675 0.0536468922368568 no 3160 0.0756903674878811 4382 2832033 SGTC_1730 st033808 45.1 µM -1.44101325404955 0.0528798108501257 no 3161 0.074790469194322 4382 1045166 SGTC_1723 st034307 2.5525 µM -1.44147436551001 0.0528243772831297 no 3162 0.0747253571587563 4454 867466 SGTC_1462 k081-0014 26.5 µM -1.44234913501118 0.0527193415604818 no 3163 0.0746019527080846 3900 3270634 SGTC_3135 9127742 49.47 µM -1.44289173735293 0.0526542732834211 no 3164 0.0745254855506091 4522 3643468 SGTC_2665 lovastatin 100 µM -1.45253009158214 0.0515090395163531 no 3165 0.0731771341875862 4494 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1 SGTC_665 3914-0008 307 µM -1.46150833450788 0.0504601443181586 no 3166 0.0719379949906081 4438 1069549 SGTC_1264 0783-0040 158 µM -1.4694931136945 0.0495416741757189 no 3167 0.0708495441292254 4392 2855798 SGTC_2683 piperine 63.03 µM -1.47327121315978 0.0491117633525303 no 3168 0.0703389598071432 4498 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_1460 k062-0059 9.15 µM -1.47887344385041 0.0484797750648515 no 3169 0.0695870710498805 4371 1373085 SGTC_2736 butenafine 14.65 µM -1.48378228929888 0.0479313687873973 no 3170 0.068933343553741 4430 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_1002 4049-0206 172 µM -1.48383089067859 0.0479259640701331 no 3171 0.068926894893541 4450 4662749 SGTC_1980 st071811 45.7 µM -1.48555847679496 0.0477341644947189 no 3172 0.0686979725421209 4543 4974850 SGTC_2706 st078239 82.5 µM -1.49052598939574 0.0471860857431246 no 3173 0.0680429940605028 4480 15434492 SGTC_3079 9117512 49.47 µM -1.49621209786764 0.0465649265709665 no 3174 0.0672991964694339 4574 7185044 SGTC_72 0744-0168 198.391 µM -1.49830996941831 0.0463374157916795 no 3175 0.0670263675430435 4385 677577 SGTC_381 3461-2219 42.7 µM -1.50358114356626 0.0457697026187457 no 3176 0.0663446246816675 4466 2883159 SGTC_2174 5790901 200 µM -1.50471175997349 0.0456486646869531 no 3177 0.0661990991544585 4467 786020 SGTC_351 caspofungin 25 nM -1.50816819647866 0.0452802316034995 no 3178 0.0657557423736472 4483 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1 SGTC_2339 9000433 200 µM -1.51163273198761 0.0449133396160276 no 3179 0.0653136599907763 4477 2988954 SGTC_2149 5554786 194.827 µM -1.51164134043816 0.0449124309764457 no 3180 0.0653125644122643 4532 745063 YPR165W RHO1 SGTC_2183 6420625 130.508 µM -1.51339019169105 0.0447281428113391 no 3181 0.0650902874717849 4533 2897619 SGTC_1806 st050005 60.3 µM -1.52040899645536 0.0439946422361369 no 3182 0.0642041074019627 4550 5194765 SGTC_73 0327-0325 16.231 µM -1.52312104607156 0.0437138305174591 no 3183 0.0638642121716394 4318 53298 SGTC_799 1310-0557 151 µM -1.52910937850678 0.0430989064566241 no 3184 0.0631186653835651 4528 5354492 SGTC_783 0848-0141 92.7 µM -1.52930796472258 0.0430786345498434 no 3185 0.0630940580322895 4444 6755076 YHR007C | YLR033W ERG11 | RSC58 SGTC_1045 1348-1485 165 µM -1.52976510639903 0.0430319982814366 no 3186 0.0630374407755226 4491 6810614 SGTC_906 1165-0455 526 µM -1.53026227004331 0.0429813253986253 no 3187 0.062975911703829 4495 3252859 SGTC_364 0083-0097 67.7 µM -1.53941739578076 0.0420567876497476 no 3188 0.061851214938456 4533 5207356 SGTC_1238 0333-0287 48.8 µM -1.54234459731764 0.0417646010333139 no 3189 0.0614949384888162 4513 7226 SGTC_1099 5-nonyloxytryptamine 2.85 µM -1.54505896403058 0.0414951302103935 no 3190 0.0611660008293849 4520 23581825 A 5-HT1D beta serotonin receptor agonist. SGTC_2572 astragaloside iv 100 µM -1.55000409387749 0.0410078209276884 no 3191 0.0605702667014709 4487 45006101 An anti-inflammatory agent. SGTC_2291 7917025 104.35 µM -1.5500354421739 0.0410047466334424 no 3192 0.0605665047390154 4415 2964612 SGTC_1188 1403-0014 4.57 µM -1.55654419165362 0.0403704776839603 no 3193 0.0597893713889714 4544 9614867 SGTC_1481 3346-2004 36 µM -1.56095087848308 0.0399455922511844 no 3194 0.0592676706717552 4612 2770522 SGTC_1053 3366-3204 134 µM -1.56179524874052 0.039864595842705 no 3195 0.0591681157290593 4523 3632071 YPR165W RHO1 SGTC_613 3914-0030 117 µM -1.56517277119649 0.0395419402513477 no 3196 0.0587712020804692 4252 1145395 SGTC_1668 st014914 51.6 µM -1.56587695036551 0.0394749381446788 no 3197 0.0586887134660202 4553 2839556 SGTC_1150 3909-7983 10.9 µM -1.56885218964812 0.039192865152152 no 3198 0.0583411921854189 4535 23965914 SGTC_224 benfluorex 43.875 µM -1.56915832240064 0.0391639349947013 no 3199 0.0583055264097068 4535 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis. SGTC_3309 9129340 25.759 µM -1.57111375857724 0.038979552230426 no 3200 0.0580781136563288 4512 17158987 SGTC_2666 tannic acid 100 µM -1.57297100401531 0.0388050831854214 no 3201 0.0578627662051508 4498 16134267 A thiamine antagonist. SGTC_1807 st050092 58.9 µM -1.58213364950563 0.0379536343167836 no 3202 0.056809531659874 4540 5008496 SGTC_1233 0325-0408 14.2 µM -1.58312223767433 0.0378626867616012 no 3203 0.0566968029925408 4571 12874 SGTC_2893 9048488 25.97 µM -1.58696957492852 0.0375104330992262 no 3204 0.0562597678092932 4564 6467338 SGTC_2267 7931562 200 µM -1.59571176219464 0.0367199620524321 no 3205 0.0552765806664121 4500 934880 SGTC_2181 6316240 54.2555 µM -1.60506713762257 0.0358891916542134 no 3206 0.0542395152031578 4571 12779990 SGTC_140 0062-0056 502.533 µM -1.60810725222038 0.0356225635573459 no 3207 0.0539058455775465 4456 3758964 SGTC_3192 9110362 49.47 µM -1.60925054739432 0.0355227138493558 no 3208 0.0537807838385542 4537 16649480 SGTC_804 1595-0054 20.9 µM -1.6122728685706 0.0352598639971617 no 3209 0.0534512872994884 4551 761523 Stimulates phospholipase C. SGTC_528 3492-0019 172 µM -1.6126055390641 0.0352310295228229 no 3210 0.0534151171610909 4546 2869262 SGTC_3074 9116018 49.47 µM -1.61755849656246 0.0348040113720196 no 3211 0.0528788897742177 4590 17027303 SGTC_723 4182-0001 115 µM -1.61806071486924 0.034760951031309 no 3212 0.0528247568585865 4553 744821 YLR208W SEC13 SGTC_15 0266-0086 27.098 µM -1.6190939807243 0.0346724961037506 no 3213 0.0527135218651412 4615 1712902 YIL048W NEO1 SGTC_3078 9116413 49.47 µM -1.62515754754634 0.0341571298047713 no 3214 0.0520644967209538 4507 17177322 SGTC_2802 7925815 54.55 µM -1.62620872524973 0.0340684298377505 no 3215 0.0519526303380474 4535 1262923 SGTC_2612 dictamnine 15.46 µM -1.6361026779389 0.0332428093511483 no 3216 0.0509090499204556 4487 68085 A quinoline derivative and established mutagen. YOR116C RPO31 SGTC_1205 4161-2785 76 µM -1.63906273512108 0.0329990287536578 no 3217 0.0506000974691412 4556 3498106 SGTC_3097 9117246 49.47 µM -1.63939890781136 0.0329714360690264 no 3218 0.050565104483931 4586 16423892 SGTC_337 1315-0038 354 µM -1.64287137786739 0.0326875306079179 no 3219 0.0502047740471377 4554 1626437 SGTC_2001 4023502 57.655 µM -1.6439963732666 0.0325959856555674 no 3220 0.0500884757601866 4547 108941 YCR052W RSC6 SGTC_2042 p-Dimethylaminoacetophenone 200 µM -1.64490596641375 0.032522123455394 no 3221 0.0499946021683986 4569 75037 A free radical scavenger. SGTC_2241 6772625 37.8075 µM -1.65187916436452 0.0319604495967064 no 3222 0.0492795931640471 4367 2285411 SGTC_2388 9080168 200 µM -1.65219663703714 0.031935069818342 no 3223 0.0492472358979203 4591 15943073 SGTC_544 k015-0020 52.4 µM -1.65440806833546 0.0317587423734703 no 3224 0.0490223141136082 4605 3008304 SGTC_853 0419-0306 21 µM -1.65571412054751 0.0316549832440344 no 3225 0.0488898631799442 4609 762713 SGTC_3276 9139060 49.47 µM -1.65780096894989 0.0314897753802402 no 3226 0.0486788228467488 4639 4870619 SGTC_62 0180-0423 3.232 µM -1.66080696973062 0.0312530550795554 no 3227 0.0483761104631635 4525 30102 YGL099W LSG1 SGTC_1550 gossypolone 36.6 µM -1.66604364177375 0.0308441870476361 no 3228 0.0478523611912266 4593 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_278 4092-0821 23.9 µM -1.66962206028516 0.0305673463297694 no 3229 0.04749708146759 4559 877900 SGTC_2614 arthonioic acid 13.39 µM -1.67728876450819 0.0299811441948725 no 3230 0.0467430142798034 4444 6710684 SGTC_2795 7780010 54.55 µM -1.67883072921498 0.0298643776233325 no 3231 0.0465925189495349 4540 953673 SGTC_685 1278-0033 54.9 µM -1.6793919968144 0.0298219689153087 no 3232 0.0465378360082054 4620 3590572 SGTC_2186 6124449 200 µM -1.6807657691939 0.0297183790692935 no 3233 0.0464042100045963 4597 3834182 YLR033W RSC58 SGTC_219 mitoxanthrone 164.414 µM -1.69643299365542 0.0285579654380687 no 3234 0.0449019548998359 4543 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA.  YMR168C CEP3 SGTC_3092 9117248 49.47 µM -1.69724527378963 0.028498845213625 no 3235 0.0448251494753392 4695 17141857 SGTC_2615 purpurogallin-4-carboxylic acid 100 µM -1.69775822821501 0.0284615633043808 no 3236 0.0447767014107048 4535 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase. SGTC_1912 st060209 90.8 µM -1.71135865149377 0.0274877792139406 no 3237 0.0435074626357639 4581 688787 SGTC_2882 9058044 58.44 µM -1.71197964624981 0.0274439877075138 no 3238 0.0434502097242241 4601 18076804 SGTC_2293 7624732 200 µM -1.71304178606916 0.0273692222355096 no 3239 0.043352426216423 4493 894453 SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM -1.71417360137024 0.0272897392339511 no 3240 0.0432484238149426 4614 6708784 An antioxidant flavonoid SGTC_977 1348-1378 135 µM -1.71987234865751 0.0268924580154614 no 3241 0.0427278239099291 4579 X977 SGTC_887 0885-0007 9.62 µM -1.72997292151754 0.0262001731706036 no 3242 0.0418175566621338 4609 5719458 SGTC_785 1270-0111 65.3 µM -1.73010864830387 0.026190972998494 no 3243 0.0418054326876966 4523 6741994 SGTC_738 1315-0003 72.4 µM -1.74637924397976 0.0251074844504559 no 3244 0.0403725370924144 4609 6251474 SGTC_970 1315-0089 19.5 µM -1.74836828507408 0.0249776450527685 no 3245 0.0402001379802714 4593 6811083 YLR033W RSC58 SGTC_931 2812-0076 566 µM -1.75070321345752 0.0248259458128982 no 3246 0.0399985228136356 4542 3450959 SGTC_3307 9126885 69.2785 µM -1.75497971973057 0.0245501067087519 no 3247 0.0396313883721945 4581 24824909 SGTC_758 0868-0029 16 µM -1.76068329043245 0.0241862273206426 no 3248 0.0391460112326229 4557 762687 SGTC_891 0929-0073 133 µM -1.76388158282554 0.0239841707847838 no 3249 0.0388759591091636 4633 5603632 SGTC_197 4544-0043 41.561 µM -1.76660279607431 0.0238133730473889 no 3250 0.0386473862008165 4632 896523 SGTC_3082 9117008 49.47 µM -1.76762422619534 0.0237495271670497 no 3251 0.0385618725961513 4633 41448529 SGTC_1278 0874-0585 172 µM -1.77003994565813 0.0235991018358414 no 3252 0.0383602432793576 4641 766306 SGTC_816 0325-0417 81.3 µM -1.78095407718929 0.0229294378813393 no 3253 0.0374599765998002 4641 68101 SGTC_879 0831-1030 162 µM -1.78306339559272 0.0228018785586155 no 3254 0.0372879920846517 4625 1549252 SGTC_2591 skatole 100 µM -1.78813823481082 0.0224974298023039 no 3255 0.0368768541351591 4601 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite. SGTC_1564 D-Arginine 115 µM -1.79196222495134 0.022270292642197 no 3256 0.0365695086133437 4608 71070 D-isomer of arginine; arginine decarboxylase inhibitor. SGTC_480 am 92016 50 µM -1.79389453200359 0.0221562553595062 no 3257 0.036415002191928 4638 2129 K+ channel blocker. SGTC_2983 9022671 12.99 µM -1.79823703775925 0.0219017746384652 no 3258 0.0360697262643588 4615 6405161 SGTC_305 1682-2595 20.8 µM -1.80660941545673 0.0214180975856685 no 3259 0.0354116002082428 4624 226033 SGTC_838 0109-0203 71.4 µM -1.80830082794122 0.0213214880998633 no 3260 0.0352798465469122 4652 759422 SGTC_2553 4-methylesculetin 85.09 µM -1.81544586422585 0.0209174368238515 no 3261 0.034727709118194 4616 5319502 SGTC_3088 9117578 49.47 µM -1.81930436202123 0.0207019470387537 no 3262 0.0344325041392394 4684 678341 SGTC_741 4582-0002 126 µM -1.8280948346533 0.0202180274521336 no 3263 0.0337676600230811 4647 2912688 SGTC_2330 7979373 200 µM -1.85278154951693 0.0189100129375711 no 3264 0.0319568379028497 4569 1863007 SGTC_540 1187-0821 17.3 µM -1.87051752010171 0.018015337064401 no 3265 0.0307059931783808 4590 847520 SGTC_1589 2',5'-dimethoxyflavone 47.2 µM -1.87543797938888 0.0177736185065941 no 3266 0.0303662471620936 4643 688667 SGTC_338 4055-0136 114 µM -1.89176084704388 0.0169914713147904 no 3267 0.0292614260573144 4647 2900563 SGTC_2889 9059656 51.95 µM -1.90300858885935 0.0164697980994537 no 3268 0.0285197122617735 4692 3949838 SGTC_2792 7535235 81.82 µM -1.91436336780814 0.0159571292297869 no 3269 0.0277868714016411 4616 1281891 SGTC_1889 st059080 5.18 µM -1.91473135829627 0.0159407459086363 no 3270 0.0277633861468271 4641 176925 Isolated from Daphnopsis sellowiana. SGTC_3268 9137683 49.47 µM -1.93407944525933 0.0150994238415446 no 3271 0.0265516803622502 4707 1953228 SGTC_2972 9093619 59.92 µM -1.93510365292827 0.0150559715479048 no 3272 0.0264887886784147 4630 25236256 SGTC_2842 9000675 19.48 µM -1.93891310844391 0.0148952962489311 no 3273 0.0262559597558329 4636 2989072 SGTC_1442 4112-3290 3 µM -1.94756193414908 0.0145359705002631 no 3274 0.025733701127692 4693 704353 SGTC_359 0081-0058 15.9 µM -1.95993266084241 0.0140349938596166 no 3275 0.025001830771893 4643 3494159 SGTC_633 0437-0093 97.7 µM -1.96634250675501 0.0137813185510958 no 3276 0.0246295299170401 4627 2831118 SGTC_1614 st002383 48.6 µM -1.97573725591562 0.01341666313045 no 3277 0.0240922715110133 4702 1947235 SGTC_904 1141-0088 396 µM -1.97816080609495 0.013323956440964 no 3278 0.0239552843503909 4677 1378119 SGTC_2289 7946404 165.07 µM -1.99136060545391 0.0128286856306408 no 3279 0.02322062848166 4654 1246120 YPR165W RHO1 SGTC_3222 9128301 49.47 µM -1.9944427207533 0.0127153616180222 no 3280 0.023051846885394 4626 4911358 SGTC_2110 5483698 200 µM -1.99489454308187 0.0126988219098277 no 3281 0.0230271914090288 4672 2848765 YHR062C RPP1 SGTC_3220 9131269 49.47 µM -2.00499622305144 0.0123338639385518 no 3282 0.0224817254084548 4697 17722206 SGTC_772 k072-0172 35.3 µM -2.01318405997917 0.0120447516359062 no 3283 0.0220476347595045 4704 5861980 SGTC_1473 k844-0725 134 µM -2.01625593928848 0.0119378094716631 no 3284 0.0218866098392359 4706 54682906 SGTC_3012 9080433 71.4286 µM -2.01772060264934 0.0118871103566805 no 3285 0.0218101839421619 4682 17688859 SGTC_2557 derrustone 83.84 µM -2.02024583463448 0.0118001383726032 no 3286 0.0216789470695362 4665 629853 An antioxidant. SGTC_136 0097-0015 404.482 µM -2.0210142141419 0.0117737842756088 no 3287 0.0216391468488843 4684 4861337 SGTC_2234 tolnaftate 200 µM -2.02335288651378 0.0116938859054831 no 3288 0.0215183889506636 4757 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7 SGTC_376 3970-0862 59.1 µM -2.05031077593493 0.0108063440638771 no 3289 0.0201670568499573 4706 3135186 SGTC_1445 4239-0156 97.7 µM -2.06118619559274 0.0104652415464544 no 3290 0.0196426399957735 4709 4008346 SGTC_2780 5215298 71.43 µM -2.0622866291784 0.0104312554250062 no 3291 0.0195902276241235 4690 2834131 SGTC_765 1319-0117 244 µM -2.06847396362054 0.0102419493642465 no 3292 0.0192977382198059 4676 3487746 YGL099W LSG1 SGTC_3067 9117431 49.47 µM -2.07261964944934 0.0101167917065477 no 3293 0.0191038454458044 4687 17150885 SGTC_1474 0330-0125 5.35 µM -2.07533417025619 0.0100355655243261 no 3294 0.0189777873236545 4746 X1474 SGTC_2639 lactacystin 53 µM -2.08441851361818 0.00976786142053578 no 3295 0.0185610576257602 4695 3870 A proteasome inhibitor. SGTC_2232 chlorophetanol 41.5365 µM -2.09841517224855 0.00936760667055083 no 3296 0.0179342430821811 4745 15907 An antifungal of unknown mechanism. YFR051C RET2 SGTC_323 4013-0906 34.3 µM -2.10935465735442 0.00906483871177094 no 3297 0.0174569901083697 4727 2910086 SGTC_890 0929-0006 47.2 µM -2.11704436805834 0.00885717533680746 no 3298 0.0171280412288947 4710 1378169 SGTC_1670 st016595 4.04 µM -2.12735217227199 0.00858535563930106 no 3299 0.016695416442993 4733 597879 SGTC_2934 9036370 36.88 µM -2.13286514290823 0.00844300255999149 no 3300 0.0164678952495333 4670 6462800 SGTC_704 1310-0270 142 µM -2.14836766443222 0.00805374981828363 no 3301 0.0158422797200732 4702 5718033 SGTC_311 1315-0136 58 µM -2.1723948689444 0.0074816014157497 no 3302 0.014912945854508 4730 6759207 SGTC_449 xestospongin c 11.1929 µM -2.17825405388021 0.00734763133534142 no 3303 0.0146935638918367 4731 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1 SGTC_2965 9082772 38.63 µM -2.18863365529543 0.00711548636058319 no 3304 0.0143117388102071 4690 16459634 SGTC_531 3788-1495 174 µM -2.19077052017829 0.00706850558845447 no 3305 0.0142342014724308 4715 2896655 SGTC_3212 9128307 49.47 µM -2.20004360192627 0.00686778572597327 no 3306 0.0139019008271008 4633 27243542 SGTC_1674 st016616 23.6 µM -2.22382468110679 0.00637586490811036 no 3307 0.0130801210754486 4718 625830 SGTC_1154 4088-0362 150 µM -2.2412572355258 0.0060353368454699 no 3308 0.0125047086586203 4749 6618304 SGTC_2050 5263056 171 µM -2.25173629732768 0.00583848613417125 no 3309 0.0121694707171801 4707 763468 YGL055W OLE1 SGTC_997 3996-0078 137 µM -2.27352785664599 0.00544727234902747 no 3310 0.0114971946960988 4745 735687 SGTC_2793 7325131 81.82 µM -2.3075784977022 0.0048825187941898 no 3311 0.0105112957992674 4717 4176441 SGTC_1226 3909-7979 35.4 µM -2.31455347448277 0.00477349095036671 no 3312 0.01031869078221 4727 6615510 SGTC_386 1509-0011 3.07 µM -2.32134937803847 0.00466935571329717 no 3313 0.0101339976383998 4744 3107280 SGTC_2119 5528445 120.635 µM -2.32510334487077 0.00461270604152692 no 3314 0.0100332174223154 4739 791935 SGTC_2680 butyl paraben 22.24 µM -2.33127901764048 0.00452084495278103 no 3315 0.00986932594102941 4780 7184 An antifungal and steroid mimetic. SGTC_2560 caryophyllene 100 µM -2.34860832759834 0.00427173839004099 no 3316 0.00942185847546187 4764 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor. SGTC_2856 9022925 19.48 µM -2.36292860759511 0.00407522508193453 no 3317 0.00906558101961379 4721 4944862 SGTC_557 1315-0110 16.2 µM -2.4127407923121 0.00345314851217603 no 3318 0.00791653758940023 4747 6833801 SGTC_3280 9140961 49.47 µM -2.44200600992479 0.00312879766319359 no 3319 0.00730295173607347 4756 4901226 SGTC_2867 9039098 71.43 µM -2.44536639525313 0.0030933664880054 no 3320 0.00723525258738699 4738 6463460 SGTC_430 0958-0115 16.4 µM -2.45221490972836 0.00302227349758388 no 3321 0.0070989918217482 4717 6833180 SGTC_352 k048-0007 5.11 µM -2.45973359898658 0.00294592143667162 no 3322 0.00695200901032729 4704 6811911 SGTC_2824 7998404 51.95 µM -2.52815149425201 0.00232705123937947 no 3323 0.00573324312994064 4744 837851 SGTC_456 gingerol 170 µM -2.53579430341569 0.00226579409278277 no 3324 0.00560963061889156 4751 442793 A herb. SGTC_2294 7971431 200 µM -2.54461412819465 0.0021969212399416 no 3325 0.00546992776520023 4751 5741572 SGTC_147 4466-0538 29.23 µM -2.54588286569776 0.00218717149348414 no 3326 0.00545008787690416 4744 6742687 YHR072W ERG7 SGTC_1763 st044482 94.5 µM -2.56219775473835 0.00206524601146956 no 3327 0.00520060377957593 4761 88505 SGTC_166 k072-0058 166.424 µM -2.59394115208724 0.00184553301123627 no 3328 0.00474413628987648 4689 5846229 SGTC_1970 st070122 35.8 µM -2.60776646456658 0.0017566628789208 no 3329 0.00455675537234221 4766 102928 SGTC_3054 9094397 49.47 µM -2.65668300061661 0.00147259857595664 no 3330 0.00394568039350508 4753 2598354 SGTC_2984 9022109 38.96 µM -2.66526693625583 0.00142730919025679 no 3331 0.00384636167768155 4773 6459207 SGTC_1463 k081-0032 34.1 µM -2.73333301678815 0.00111079600645625 no 3332 0.00313484527381417 4390 977755 SGTC_1191 1487-1166 10.6 µM -2.82567069306271 0.000783785201203272 yes 3333 0.00235908710541827 4777 3955771 SGTC_2449 5812982 45.77 µM -2.84968719835361 0.000714668152876991 yes 3334 0.00218811222616162 4752 776185 SGTC_2636 apigenin dimethyl ether 100 µM -2.90589360668846 0.000574295505471738 yes 3335 0.00183102971557789 4764 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_170 4197-0004 226 µM -2.91851902221044 0.00054649113612763 yes 3336 0.00175849208211368 4768 218692 SGTC_1663 st014140 55.4 µM -2.92464364299408 0.00053345646375126 yes 3337 0.00172425440787338 4799 4207120 SGTC_1015 4130-4525 82 µM -2.9694540874139 0.000446492563552394 yes 3338 0.00149164694763967 4789 1363237 SGTC_1596 piperlongumine 63 µM -3.0707315713158 0.000296065000111649 yes 3339 0.00106767514074038 4799 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_1600 coumarin 106 71.1 µM -3.09474441656634 0.000268112782431294 yes 3340 0.000984912797631544 4799 100336 A hepatotoxic, DNA x-linker. SGTC_436 n,n-dimethylsphingosine 3.3 µM -3.12337706360219 0.000238000703374751 yes 3341 0.000893942688684974 4787 5282309 SGTC_631 k072-0230 41.5 µM -3.16760875582352 0.000197619800826432 yes 3342 0.000768491050742775 4798 5773147 SGTC_2952 9073731 13.78 µM -3.19568932087501 0.000175408186186672 yes 3343 0.000697486153673628 4777 16457353 SGTC_1785 bathophenanthroline 24 µM -3.22918763841619 0.000151968112460202 yes 3344 0.000620712068056355 4769 72812 An iron chelator. SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM -3.41721012567838 6.62874617294972e-05 yes 3345 0.000316332141522437 4804 16623 A steroid. SGTC_2943 9068529 45.32 µM -3.74328175949185 1.42396742408002e-05 yes 3346 9.08161811587457e-05 4792 3270634 SGTC_1737 st035557 69.7 µM -3.7908160666432 1.12603041289602e-05 yes 3347 7.50765612820036e-05 4788 5716916 SGTC_1111 tnp00062 510.699 nM -3.86040719705458 7.94667560602516e-06 yes 3348 5.65991137530016e-05 4787 676306 SGTC_325 2810-4341 181 µM -4.07587606839738 2.60383024177468e-06 yes 3349 2.29207150893223e-05 4808 774970 SGTC_458 nppb 133 µM -4.18740132271579 1.42998213691847e-06 yes 3350 1.41083316953957e-05 4809 4549 A chloride channel blocker. SGTC_394 menadione 8.33 µM -4.38600713650526 4.74000475670279e-07 yes 3351 5.77251674549028e-06 4808 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_1108 betulinic acid 729.144 nM -5.51085467048488 3.71401049128465e-10 yes 3352 1.78547739705837e-08 4790 64945 Apoptosis-inducing agent of unknown mechanism. SGTC_2962 9082311 13.18 µM -5.84560920279841 3.2874432011013e-11 yes 3353 2.52358848950392e-09 4808 16459453 SGTC_302 1094-0063 18.9 µM -6.28865189496658 1.07664965674898e-12 yes 3354 1.60117320347183e-10 4809 5440289 SGTC_2950 9072895 21.46 µM -6.62493600186696 6.84831854146998e-14 yes 3355 1.73699328241439e-11 4808 17332245 SGTC_1112 tnp00069 1.16933 µM -7.10089290156815 1.09502328962275e-15 yes 3356 6.1976704445839e-13 4806 145826