SGTCid condition conc unit RAD54|YGL163C.score RAD54|YGL163C.strain.pval RAD54|YGL163C.strain.significant RAD54|YGL163C.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene SGTC_1707 st032323 6.317 µM 11.2869498492466 1.77859604001548e-23 yes 1 7.61140233136295e-30 8 3132057 YMR211W DML1 SGTC_829 1635-0120 117 µM 10.3137862099504 7.18639228022989e-20 yes 2 3.05238996906098e-25 5 285054 SGTC_2612 dictamnine 15.46 µM 10.1648833604577 2.39822905523467e-19 yes 3 1.42231147496187e-24 2 68085 A quinoline derivative and established mutagen. YOR116C RPO31 SGTC_244 nsc-207895 1.295 µM 9.78082501520837 4.95470962692016e-18 yes 4 6.80482985410466e-23 4 42640 SGTC_3247 9135149 49.47 µM 8.59065369556291 2.8340900551192e-14 yes 5 4.32379539743204e-18 4 8934436 YOR116C RPO31 SGTC_1718 roemerine 11.9335 µM 8.28914479538097 2.12845537845751e-13 yes 6 5.70328091621596e-17 7 235224 An aporphine alkaloid with mutagenic activity. SGTC_2947 9072639 7.68 µM 8.15020386861788 5.2629497414346e-13 yes 7 1.81655631691926e-16 8 16488146 SGTC_1936 st074407 74.3 µM 7.49673099018513 3.04030714141751e-11 yes 8 3.27145325926903e-14 4 809813 SGTC_1082 camptothecin 424.86 nM 7.12194149622391 2.68122364798746e-10 yes 9 5.32086151023607e-13 15 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_3028 9087778 49.47 µM 6.78571395565109 1.72292704678445e-09 yes 10 5.77569100684732e-12 2 17217395 SGTC_429 1112-0049 25.5 µM 6.69973754982564 2.73380393749081e-09 yes 11 1.04397096359147e-11 10 2836170 SGTC_1930 st074634 34.3 µM 6.67534213720436 3.11319810936953e-09 yes 12 1.23328022260871e-11 6 684253 YOR116C RPO31 SGTC_268 camptothecin 39.6153 µM 6.65482010348653 3.47160575326016e-09 yes 13 1.41823388257395e-11 22 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_1703 st026983 48.3 µM 6.43447339043089 1.09585366052877e-08 yes 14 6.19510706017995e-11 1 1104023 SGTC_1079 idarubicin 2.36 µM 6.4208080978501 1.17537728645004e-08 yes 15 6.77764109384148e-11 5 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_1532 4',5'-dihydroxyflavone 78.7 µM 6.31216683700391 2.04096234711955e-08 yes 16 1.37577678807167e-10 8 165521 SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM 6.14618858946367 4.65964607804572e-08 yes 17 3.96834566057216e-10 18 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair. SGTC_2671 danthron 100 µM 5.82267568260575 2.19135372629573e-07 yes 18 2.89564351255576e-09 15 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin. SGTC_219 mitoxanthrone 164.414 µM 5.64752584727055 4.89976820050982e-07 yes 19 8.13866845925675e-09 20 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA.  YMR168C CEP3 SGTC_558 k064-0027 21.3 µM 5.61089979535668 5.78046256002858e-07 yes 20 1.00638647009261e-08 7 5088526 SGTC_3254 9136651 49.47 µM 5.60556530490559 5.92080818427681e-07 yes 21 1.03788168161531e-08 5 16454030 SGTC_1627 st003713 25.6 µM 5.58049504645255 6.62547780571882e-07 yes 22 1.19917491602126e-08 34 16195070 YER133W GLC7 SGTC_1913 st060213 96.1 µM 5.57680852167372 6.73567067298778e-07 yes 23 1.22485628081267e-08 8 688959 SGTC_1036 k216-0215 33.5 µM 5.48152712039558 1.02793429865596e-06 yes 24 2.10835033628578e-08 16 622330 SGTC_1425 4048-4433 7.33 µM 5.18653031885547 3.64135619143524e-06 yes 25 1.07124078854709e-07 18 23734946 SGTC_1049 3226-0134 66 µM 5.16280610081676 4.01963874088467e-06 yes 26 1.21637550462276e-07 7 5702385 SGTC_2434 5670830 169.91 µM 5.12424188454603 4.71588933743641e-06 yes 27 1.49368638490578e-07 8 1549830 SGTC_248 streptozotocin 5.23457 mM 5.04603959334166 6.49740864907458e-06 yes 28 2.25530987114187e-07 14 5300 DNA alkylating agent. SGTC_2760 etidronate 98.04 µM 5.01535795072221 7.35855912472933e-06 yes 29 2.64674107657807e-07 10 3305 A chelator and antioxidant. SGTC_1927 st060202 13.8 µM 5.00919195156075 7.54428502447391e-06 yes 30 2.73295187419271e-07 11 688887 SGTC_1915 st067105 30.6 µM 4.99608715476804 7.95396721946821e-06 yes 31 2.92526138625726e-07 19 69751 YOR207C | YOR116C RET1 | RPO31 SGTC_2383 9036125 200 µM 4.86821172563082 1.32345547404423e-05 yes 32 5.63063217834982e-07 3 79580 SGTC_824 1304-0008 100 µM 4.82887655341362 1.54399351288879e-05 yes 33 6.8652745435568e-07 23 768245 SGTC_318 1488-0629 67.2 µM 4.72936891992028 2.26831749883907e-05 yes 34 1.12609404194499e-06 15 3662576 SGTC_73 0327-0325 16.231 µM 4.72532057767066 2.30372957590976e-05 yes 35 1.14876307684432e-06 28 53298 SGTC_3044 9093193 49.47 µM 4.64712482648207 3.09972752452993e-05 yes 36 1.68296751567281e-06 15 25236277 SGTC_2433 5607874 27.82 µM 4.60793798668473 3.59055332105075e-05 yes 37 2.03340953095278e-06 11 2252428 SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM 4.58464874532305 3.91617843372281e-05 yes 38 2.27375130372885e-06 24 368090 SGTC_1105 epirubicin 18.1 µM 4.39571460202459 7.80096167876658e-05 yes 39 5.52044608634303e-06 13 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_787 4152-0075 138 µM 4.3485801821987 9.22557930741962e-05 yes 40 6.85108610984259e-06 17 9566539 SGTC_1050 3232-1156 69.3 µM 4.34153780018326 9.45834741878152e-05 yes 41 7.07444651215629e-06 14 700529 SGTC_93 0109-0045 59.227 µM 4.27959339180847 0.000117572194057492 yes 42 9.36175299643927e-06 29 88733 SGTC_273 hydroxyurea 18.1 mM 4.23373587330976 0.000137863573259767 yes 43 1.14920436106396e-05 30 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12 SGTC_1298 1079-1278 263 µM 4.23288145529999 0.000138271075160982 yes 44 1.15358065218944e-05 11 2840950 SGTC_620 0109-0052 432 µM 4.21141769079687 0.000148885904405563 yes 45 1.26886509967612e-05 14 493037 SGTC_2070 5230947 200 µM 4.20931642583673 0.000149965111846947 yes 46 1.28072228631966e-05 5 2835538 SGTC_1845 st056753 3.01 µM 4.16939049789529 0.000171916071776909 yes 47 1.52707655531632e-05 32 5375839 SGTC_2611 pyromycin 23.93 µM 4.08724927362913 0.000226851157833836 yes 48 2.18259011922294e-05 23 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release. SGTC_915 methyl methanesulfonate (MMS) 110 mM 4.00010968337797 0.000302760661498752 yes 49 3.16565661015163e-05 40 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks. SGTC_1719 st032227 49.2 µM 3.96399527921783 0.00034066858786533 yes 50 3.68528552383264e-05 22 3125804 SGTC_707 0865-0008 204 µM 3.91342904688524 0.000401196462162598 yes 51 4.54973231951345e-05 6 723043 SGTC_1723 st034307 2.5525 µM 3.88020193526462 0.000446249304720923 yes 52 5.21848882328357e-05 32 867466 SGTC_2945 9067681 61.76 µM 3.8439941590779 0.000500654579327828 yes 53 6.0523943858609e-05 17 16456930 SGTC_1466 k213-0079 57.5 µM 3.83641984774791 0.000512785742162086 yes 54 6.24204572178646e-05 22 3657981 SGTC_1152 3909-8331 15.9 µM 3.80367652395518 0.000568423308002967 yes 55 7.12821594300014e-05 10 16001939 SGTC_3031 9088762 49.47 µM 3.80161247566776 0.000572111031820424 yes 56 7.18787261337594e-05 25 205253 SGTC_625 k213-0058 121 µM 3.79505041334754 0.000583982535022401 yes 57 7.38067293942177e-05 117 3655420 SGTC_1740 st038286 13.222 µM 3.77342925642695 0.0006247271716394 yes 58 8.05094462287978e-05 30 716786 SGTC_1975 st070967 30.8 µM 3.72146896181418 0.000733611550979838 yes 59 9.90336070288548e-05 41 261391 SGTC_2442 5158906 48.48 µM 3.71999344020544 0.00073694470263528 yes 60 9.96139762070231e-05 27 1893835 SGTC_1290 0986-0249 10.2 µM 3.71257177467429 0.000753922609528362 yes 61 0.000102581926076217 28 53329 SGTC_2065 5221596 34.26 µM 3.69691002630365 0.000790939345206153 yes 62 0.000109119823094318 21 788581 SGTC_1982 st072467 71.9 µM 3.69379042444975 0.000798509522205256 yes 63 0.00011046795601871 44 3163533 SGTC_2677 mitomycin C 100 µM 3.67230719977901 0.000852479935763581 yes 64 0.000120185242991878 17 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_2152 5568786 200 µM 3.64120882877081 0.000936565695975566 yes 65 0.000135680454819193 19 5399883 SGTC_411 enrofloxacin 100 µM 3.54606481469445 0.0012433766913292 no 66 0.000195515008673525 15 71188 A bacterial gyrase inhibitor. SGTC_2682 pyrogallin 40.03 µM 3.53618782148349 0.00128000596694875 no 67 0.000202972984088611 41 822798 An ATP competetive kinase inhibitor. SGTC_1442 4112-3290 3 µM 3.52493905410299 0.00132292276519385 no 68 0.0002117901161413 26 704353 SGTC_1834 st055981 52.8 µM 3.47130783719235 0.0015461943498623 no 69 0.000258964940094783 48 471719 YDL150W RPC53 SGTC_960 1222-0186 7.7 µM 3.46568080994198 0.0015715096162785 no 70 0.000264445384235306 50 3126296 SGTC_1684 st024538 14.6195 µM 3.44945254964177 0.00164664905128273 no 71 0.000280862221369751 13 6732859 SGTC_59 0330-0160 1.33 µM 3.43155415913916 0.00173330544379774 no 72 0.000300066642494222 157 4293482 SGTC_1660 st012960 28.1 µM 3.41068725222027 0.00183956174995763 no 73 0.000323996860151609 55 24207266 SGTC_706 4262-0057 46.9 µM 3.38983451369506 0.00195162973070921 no 74 0.000349674134704168 60 883298 SGTC_1170 0310-0127 64.8 µM 3.37028872539582 0.00206226755106757 no 75 0.000375447310074258 44 774975 SGTC_811 0416-0114 265 µM 3.32401558634714 0.00234722307511532 no 76 0.0004436561831742 49 6612453 SGTC_3151 9099821 49.47 µM 3.32156649094215 0.00236325388047034 no 77 0.000447568257869494 43 17174189 SGTC_348 k064-0012 10.7 µM 3.31616248871163 0.002398977461446 no 78 0.000456313746774941 35 5066323 SGTC_1943 st076331 65.2 µM 3.30359763382913 0.00248393464301357 no 79 0.000477263625204197 37 24208415 SGTC_1357 1503-1303 39.5 µM 3.29382249646867 0.0025519007689689 no 80 0.000494174454413721 68 292895 SGTC_1320 1313-0481 95.3 µM 3.29204394648512 0.0025644461776595 no 81 0.000497310340756015 40 6813365 YLR208W SEC13 SGTC_420 mitomycin C 81.9 mM 3.27234353363074 0.00270718276913985 no 82 0.000533299454377603 35 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_580 1123-0028 41 µM 3.25216676618879 0.00286076850346438 no 83 0.000572644016772843 67 1677248 YPR107C YTH1 SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM 3.24533749541114 0.00291450629370551 no 84 0.000586557494753732 53 2333 A French combination drug. SGTC_2993 9054257 71.4286 µM 3.2329915289268 0.00301396799208654 no 85 0.00061250597569081 79 6470217 YGL055W OLE1 SGTC_1838 st055369 84.5 µM 3.20331916320276 0.00326563390242427 no 86 0.000679266650315746 41 676036 SGTC_362 0310-0100 9.03 µM 3.1605743284383 0.00366142982125975 no 87 0.000787292124334235 75 790235 SGTC_21 0849-0113 22.993 µM 3.1517861024495 0.00374795057850775 no 88 0.000811375497143959 64 1560156 SGTC_272 doxorubicin 8.13 µM 3.13509308924712 0.00391735838713395 no 89 0.00085899792737459 64 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_2804 7954240 19.48 µM 3.11336920236639 0.00414808128783093 no 90 0.00092482237487985 71 828705 SGTC_1865 st057639 52.2 µM 3.10452753711504 0.00424541576536316 no 91 0.000952915930837106 41 688818 SGTC_2397 5161689 200 µM 3.08602511025569 0.0044557371176929 no 92 0.00101425845343094 78 2259942 SGTC_1439 4092-1168 46 µM 3.08425347322841 0.00447635600303955 no 93 0.00102031827059309 33 2886240 SGTC_121 0557-0495 61.343 µM 3.07986867687542 0.00452775457990711 no 94 0.00103545942512614 125 3104427 SGTC_843 0310-0051 143 µM 3.06397118106031 0.00471855183853659 no 95 0.00109209974862984 47 2065037 SGTC_451 chloral hydrate 100 µM 3.02154121968649 0.0052633566407613 no 96 0.00125745698336238 110 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1 SGTC_2044 5102272 200 µM 2.96396983367723 0.00609181125249764 no 97 0.00151849028435842 42 592666 SGTC_369 0957-0393 4.5 µM 2.95482207279572 0.00623358451818268 no 98 0.00156424709872674 71 6997992 SGTC_1745 st081495 74 µM 2.95153039651323 0.00628530973955562 no 99 0.00158101710984052 151 13842402 YBL026W LSM2 SGTC_3311 9131146 2.8755 µM 2.93975875781032 0.0064734115714227 no 100 0.00164233938894934 180 4900406 YPR165W RHO1 SGTC_720 r052-1644 49.9 µM 2.92883611655137 0.00665238364268289 no 101 0.00170116878511515 68 1422863 YOR257W CDC31 SGTC_2510 benzyl isothiocyanate 8.31 µM 2.91217485604559 0.00693381298768044 no 102 0.00179460826740155 58 2346 DNA damaging agent; causes G2/M arrest. SGTC_1878 temozolomide 1 mM 2.90021851565547 0.00714219849557312 no 103 0.00186451299091452 43 5394 DNA alkylating agent. SGTC_2280 7785178 200 µM 2.871036882213 0.0076741608335023 no 104 0.00204563893315839 44 2954328 SGTC_1253 0550-0034 176 µM 2.85964108016452 0.00789118558607552 no 105 0.00212060361300036 76 5969915 SGTC_1919 st067113 52.3 µM 2.84124309755296 0.00825296330372544 no 106 0.00224690211860053 95 1268243 SGTC_1640 st009078 66.4 µM 2.83853885382625 0.00830734949002937 no 107 0.00226603007233367 54 690618 SGTC_1431 4049-0260 9.09 µM 2.83721305409641 0.00833412799816768 no 108 0.00227546164772547 46 3854841 SGTC_755 1995-0008 37.3 µM 2.8214838758753 0.00865765656140715 no 109 0.002390102023648 64 689533 SGTC_1051 3253-3903 78 µM 2.78588983720513 0.00943072427317587 no 110 0.00266905048493455 90 5509239 SGTC_3146 9095609 49.47 µM 2.77401564741133 0.00970172162971506 no 111 0.00276845074866937 82 17173999 SGTC_1547 harmine 94.2 µM 2.77015444903804 0.00979129747121883 no 112 0.00280148585207199 120 5280953 A monoamine oxidase inhibitor YHR072W ERG7 SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM 2.76482856467997 0.00991603757136778 no 113 0.00284763593556218 63 364106 SGTC_1085 doxorubicin 7.67 µM 2.73795636755162 0.0105668108629022 no 114 0.00309111387750086 95 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_2931 9014674 55.67 µM 2.73069708857577 0.0107488723858461 no 115 0.00316002655417867 84 2996810 SGTC_629 3448-6466 76.7 µM 2.71120326558455 0.0112513504748229 no 116 0.00335197577200736 88 573744 SGTC_2992 9074591 71.4286 µM 2.70035644925595 0.0115396871100884 no 117 0.00346326105554315 68 17741321 SGTC_1777 st045864 34.765 µM 2.68694124587994 0.0119051569969334 no 118 0.00360548177904481 63 4691462 SGTC_1516 st013856 110 µM 2.6861680068542 0.0119265250024171 no 119 0.00361383679407125 63 5281404 A mutagen and neurotoxin. SGTC_177 1327-0068 8.361 µM 2.68339602093556 0.0120034008219326 no 120 0.00364393168749778 129 15389900 YOR207C | YLR033W RET1 | RSC58 SGTC_3002 9075603 71.4286 µM 2.67379666026659 0.0122729510672838 no 121 0.00374989551387258 97 20105405 SGTC_2775 cyproheptadine 69.59 µM 2.6573927876556 0.0127457191002976 no 122 0.00393738167265461 68 2913 A selective serotonin reuptake inhibitor. SGTC_2459 5811157 9.22 µM 2.64787556284715 0.0130271697536485 no 123 0.00404996670602573 72 2870684 YBR192W RIM2 SGTC_1708 st033234 31.827 µM 2.64501421614196 0.013112831346315 no 124 0.00408437425224748 74 674664 SGTC_1549 4'-methoxyflavonol 74.6 µM 2.63693710053358 0.0133572715947162 no 125 0.00418291711443683 68 97141 SGTC_1651 st011928 86.1 µM 2.63056466889977 0.0135528900431045 no 126 0.00426215749765824 70 720198 SGTC_2030 5175110 200 µM 2.62682085796317 0.013668965325452 no 127 0.00430933473113512 92 2831986 SGTC_3249 9135183 49.47 µM 2.61417659387219 0.014067358076787 no 128 0.00447213965909278 93 4902779 SGTC_1958 st076513 41.9 µM 2.61279636762464 0.0141114458147841 no 129 0.00449023960318197 137 732122 YGL099W LSG1 SGTC_1494 4358-1428 177 µM 2.61025780960698 0.014192844383116 no 130 0.00452370050513937 88 1564571 SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM 2.60335471485898 0.0144162398542798 no 131 0.00461581926692887 101 5393153 SGTC_1194 1488-0194 225 µM 2.6019435188556 0.0144622793127236 no 132 0.00463485586967664 124 1391452 SGTC_1147 3809-1045 12.3 µM 2.5913327101374 0.0148125219566099 no 133 0.00478025056892372 129 325925 SGTC_2124 5246320 200 µM 2.55621460677032 0.0160242030927716 no 134 0.0052908917046223 113 579342 SGTC_2793 7325131 81.82 µM 2.55034268291068 0.0162348778074481 no 135 0.00538085403940996 98 4176441 SGTC_3051 9093778 49.47 µM 2.54835980258955 0.0163065540638442 no 136 0.00541153898806411 47 17217378 SGTC_546 peri-Naphthalide 147 µM 2.54407332051495 0.0164624265523047 no 137 0.00547840413920786 92 223824 A penicillin ester. SGTC_302 1094-0063 18.9 µM 2.54115534844864 0.0165692631276675 no 138 0.00552434081040218 73 5440289 SGTC_608 k048-0125 159 µM 2.53654241743829 0.0167393681557165 no 139 0.00559765896092367 98 6817652 YLR060W | YFL022C FRS1 | FRS2 SGTC_373 0844-0104 25.9 µM 2.52656246442632 0.0171125041041719 no 140 0.00575924515233935 162 5375804 SGTC_550 4123-0385 25.7 µM 2.52161564901435 0.0173000783438348 no 141 0.00584086344874468 135 5731123 SGTC_949 1165-0505 146 µM 2.51876419300211 0.017408996230312 no 142 0.00588837484887864 124 6244267 SGTC_257 daunorubicin 18.5 µM 2.51834167276249 0.0174251850662393 no 143 0.00589544402837382 74 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_2849 9019321 12.99 µM 2.51726470072204 0.017466507334427 no 144 0.0059134968861444 135 16489627 SGTC_1633 st005664 67.9 µM 2.51719785561218 0.0174690748653656 no 145 0.00591461899852591 151 2063822 SGTC_2998 9066762 71.4286 µM 2.50620931689215 0.0178955501045867 no 146 0.00610166765847764 140 4945196 SGTC_341 1486-1430 230 µM 2.50561425546055 0.0179188962657904 no 147 0.00611194487288472 118 2054753 YPL210C SRP72 SGTC_3352 9151559 45.5865 µM 2.50400179948775 0.017982288655421 no 148 0.00613987048195127 86 17159339 SGTC_691 1548-0686 185 µM 2.50128729833495 0.0180894389865814 no 149 0.00618713744952889 162 46495133 SGTC_936 3005-4620 401 µM 2.49574187231021 0.0183100277309507 no 150 0.00628470152485004 138 777207 SGTC_336 4111-0029 111 µM 2.49481109898525 0.0183472762084762 no 151 0.00630121001921412 84 3131175 SGTC_391 gliotoxin 8.33 µM 2.48860637949884 0.0185972350332474 no 152 0.00641224320084692 167 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion SGTC_1453 4237-0541 195 µM 2.47227193695662 0.0192691736264662 no 153 0.00671286732752606 126 739892 SGTC_433 pimozide 108 µM 2.46839597550675 0.0194316113118097 no 154 0.0067860046468128 89 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic SGTC_1879 gemcitabine 100 µM 2.4652891890529 0.019562652202292 no 155 0.00684513542234514 111 60750 A nucleoside analog which inhibits DNA replication. SGTC_1782 st039423 80.636 µM 2.45784423125044 0.019879729647499 no 156 0.00698868925337985 137 2068169 SGTC_752 1896-0090 130 µM 2.45485935536011 0.0200080734114933 no 157 0.00704698590839805 109 772567 SGTC_1296 1068-0102 11.9 µM 2.44873530477852 0.0202735970516423 no 158 0.00716793784399575 101 767053 SGTC_116 0155-0182 31.788 µM 2.44483290087378 0.0204443491593705 no 159 0.00724596340172238 257 771486 SGTC_141 0443-0274 32.331 µM 2.44254300295492 0.0205451112899325 no 160 0.00729209599295964 205 1627241 SGTC_3325 9138760 55.175 µM 2.43588647258729 0.0208404100401525 no 161 0.00742767302739953 125 43844959 SGTC_2203 7227154 166.4 µM 2.39893717347662 0.0225456623366144 no 162 0.00822136780294926 98 896304 SGTC_1062 mesoridazine 14.2 µM 2.38645811260633 0.0231475397153998 no 163 0.00850577258374737 129 4078 A neuroleptic. SGTC_1727 st034309 9.9045 µM 2.38566774307826 0.0231861113042996 no 164 0.00852407282118118 199 870305 SGTC_1995 st072814 61.1 µM 2.3847711791182 0.0232299308805253 no 165 0.00854487370172675 123 5769371 SGTC_2389 9091542 195.52 µM 2.3844735108868 0.0232444948258281 no 166 0.00855178964363957 149 3626624 YOL127W RPL25 SGTC_1624 st003710 6.25 µM 2.37074268714214 0.023924702893523 no 167 0.00887619258046888 169 24207033 SGTC_1525 8-methoxypsoralen 92.5 µM 2.36311333888013 0.0243098286819526 no 168 0.00906106319919593 159 4114 Related to psoralen; DNA damaging agent. SGTC_1461 k072-0203 53.8 µM 2.35704221020035 0.0246200037049185 no 169 0.00921057640842772 128 5418714 SGTC_2214 7179297 48.276 µM 2.34345349069615 0.025326302995804 no 170 0.00955307209744684 73 769744 SGTC_2990 9074105 71.4286 µM 2.33784104920386 0.0256229338605127 no 171 0.00969774764485827 110 6502001 SGTC_3025 9087895 49.47 µM 2.33468674494827 0.0257909193017352 no 172 0.00977989560769214 146 17173641 SGTC_793 0488-0545 106 µM 2.32016958618593 0.026575971247374 no 173 0.010165852586936 154 292548 SGTC_661 1304-0007 33.6 µM 2.31892806246293 0.0266440266775405 no 174 0.0101994686186326 131 3117130 SGTC_838 0109-0203 71.4 µM 2.30828853789012 0.0272332336711581 no 175 0.0104915467654893 123 759422 SGTC_1197 1601-0112 267 µM 2.30639236485541 0.0273393748853972 no 176 0.0105443591161275 168 7350313 SGTC_1214 0358-0031 63.7 µM 2.30091575719967 0.0276478754164868 no 177 0.0106981966360472 154 4301366 SGTC_31 0508-1974 57.237 µM 2.29316632641921 0.0280893581767981 no 178 0.0109192155022668 141 6810525 SGTC_1763 st044482 94.5 µM 2.29289239706866 0.0281050706482018 no 179 0.0109271003261274 148 88505 SGTC_650 1328-0195 38 µM 2.29172524220316 0.0281721001969652 no 180 0.0109607514405441 165 2780821 SGTC_2987 9018338 71.43 µM 2.2842213525903 0.0286062329790246 no 181 0.0111792626418422 167 5055682 SGTC_1518 st038567 90.8 µM 2.27901934495741 0.0289104460692554 no 182 0.0113329576872122 126 77966 SGTC_513 4245-1575 41.7 µM 2.27889701866364 0.0289176319385531 no 183 0.0113365938475976 313 719745 SGTC_472 calcifediol 10 µM 2.26826133363982 0.0295481085999895 no 184 0.0116566415707464 98 5283731 A vitamin D metabolite. SGTC_1637 st007924 17.4 µM 2.26679089343808 0.029636166532279 no 185 0.0117015013493606 152 683336 SGTC_521 r062-0005 13.8 µM 2.26103742565614 0.0299828111043489 no 186 0.0118784698121368 139 2832033 SGTC_213 1246-0773 967 nM 2.25781063104052 0.0301786917195714 no 187 0.0119787340743155 173 6251622 SGTC_893 0958-0369 48.9 µM 2.2557462819088 0.0303045623119797 no 188 0.0120432626369958 188 6819948 SGTC_1099 5-nonyloxytryptamine 2.85 µM 2.25448957639392 0.0303814008682486 no 189 0.012082692844223 145 23581825 A 5-HT1D beta serotonin receptor agonist. SGTC_965 1291-5240 308 µM 2.23740866964886 0.0314418783724112 no 190 0.0126298212129143 168 2834598 SGTC_880 0833-0487 87.2 µM 2.22883120668592 0.0319858498740067 no 191 0.0129125688664228 158 76075 SGTC_52 0329-0193 875 nM 2.22841717936309 0.0320123023548494 no 192 0.0129263542733979 168 3739292 SGTC_1272 0839-0021 27 µM 2.22389888307183 0.0323021552748498 no 193 0.0130776241217019 167 5027250 SGTC_2662 daunorubicin 22.37 µM 2.21934621955285 0.0325964000786375 no 194 0.0132315897238581 147 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_2222 6885208 172.143 µM 2.21846224285461 0.0326537882023115 no 195 0.0132616656273816 82 609514 SGTC_2681 menadione 3.18 µM 2.21611358463315 0.0328066689194459 no 196 0.0133418620569834 151 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_1193 1488-0126 41.5 µM 2.21352738877557 0.0329756937395772 no 197 0.013430653559686 181 1384710 SGTC_1817 st052116 64.4 µM 2.21130307663742 0.0331216405532375 no 198 0.0135074282232452 141 4361398 SGTC_22 0964-0034 14.468 µM 2.20696123674676 0.0334080608958719 no 199 0.0136583837920216 215 138402 SGTC_3178 9107506 49.47 µM 2.206184806624 0.0334594943869096 no 200 0.013685531319207 156 8897194 SGTC_381 3461-2219 42.7 µM 2.20519429293576 0.0335252041494702 no 201 0.0137202317504754 171 2883159 SGTC_1107 amlodipine 47 µM 2.2022356742835 0.0337221089541156 no 202 0.0138243326665651 195 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.  SGTC_3228 9131799 49.47 µM 2.20065403242728 0.033827761618793 no 203 0.0138802626650931 123 17015818 SGTC_1302 1159-0335 255 µM 2.19675994385471 0.0340890452004393 no 204 0.0140187976110472 138 649284 SGTC_476 mead acid 10 µM 2.18899409160567 0.0346150692811025 no 205 0.0142986347296907 92 5312531 An omega 9 fatty acid. SGTC_1747 st037496 66.6 µM 2.16433027533885 0.0363300550347179 no 206 0.0152195053887618 199 723305 SGTC_1485 3909-9022 254 µM 2.15466560583495 0.0370207772264702 no 207 0.0155940055534211 160 714516 SGTC_1309 pyrazolanthrone 13.4 µM 2.15119316330529 0.0372715547799107 no 208 0.0157304782200358 179 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14 SGTC_78 0336-0123 156.75 µM 2.13501786394215 0.038458076120011 no 209 0.0163797754804837 157 6765896 SGTC_450 aminopyrene 156 nM 2.12545385956013 0.0391739982962839 no 210 0.0167743801093178 219 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1 SGTC_2074 5212007 75.395 µM 2.12343403190539 0.0393265732215913 no 211 0.0168587489790938 156 758611 SGTC_307 1501-1223 22.3 µM 2.12095232770804 0.0395146993144443 no 212 0.0169629072105508 167 2830329 SGTC_371 0195-0006 7.36 µM 2.11811611079534 0.0397305949566391 no 213 0.0170826177136891 153 3928593 SGTC_868 0527-0199 213 µM 2.11712941209411 0.0398059279285842 no 214 0.0171244330535209 192 2849450 SGTC_12 0849-0099 9.267 µM 2.11662053578295 0.039844825237281 no 215 0.0171460329097826 162 6071388 SGTC_1991 st073000 8.92 µM 2.1084215161318 0.0404758090092256 no 216 0.0174972724686944 276 4301969 YIL048W NEO1 SGTC_274 sirtinol 40.1 µM 2.08426040755112 0.042382508464146 no 217 0.018568243319689 192 6836442 NAD-dependent acetyltransferase inhibitor. SGTC_2552 juarezic acid 87.02 µM 2.07678040713962 0.0429873155752069 no 218 0.0189109156789451 232 1549512 SGTC_1942 st076330 65.2 µM 2.0763612223687 0.043021414708157 no 219 0.0189302774415268 205 24208414 SGTC_2883 9059145 45.46 µM 2.07081266446209 0.0434748316684729 no 220 0.0191881531271169 157 16476510 SGTC_947 3447-0010 211 µM 2.06774992608896 0.0437267600578632 no 221 0.0193317722618529 171 748350 SGTC_719 2810-4230 27.3 µM 2.06507744310117 0.0439475487374879 no 222 0.0194578366708955 122 721079 SGTC_1635 st007035 42.4 µM 2.06238391316103 0.0441709850897171 no 223 0.019585599820205 455 3716403 SGTC_2446 5162541 200 µM 2.06069189178735 0.0443118110235262 no 224 0.0196662218363269 176 1549321 SGTC_2449 5812982 45.77 µM 2.05859002231734 0.0444872520672085 no 225 0.0197667646938009 147 776185 SGTC_2816 7982706 58.44 µM 2.05812893981592 0.0445258129341578 no 226 0.019788878820195 237 2981853 SGTC_1670 st016595 4.04 µM 2.05730805373437 0.0445945312338039 no 227 0.0198283015755126 193 597879 SGTC_2372 9071633 200 µM 2.05414278528185 0.044860303440092 no 228 0.0199809370354106 178 21321366 SGTC_1904 st060225 78 µM 2.03684244309952 0.0463355403329227 no 229 0.0208329167487664 175 66595 SGTC_3140 9094243 49.47 µM 2.02768352969461 0.0471321664088596 no 230 0.0212962788436921 225 19291112 SGTC_2776 terbinafine 19.92 µM 2.02358077958002 0.0474925593526291 no 231 0.0215066521533905 233 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_677 0929-0063 136 µM 2.0072161712405 0.0489520729006082 no 232 0.0223633252350451 148 1539583 SGTC_900 1112-0045 141 µM 1.99730571779429 0.0498532396903874 no 233 0.022895991305626 158 56211 YIL048W NEO1 SGTC_3115 9123671 49.47 µM 1.98998507652629 0.0505273716830527 no 234 0.0232962897309687 157 3286988 SGTC_647 0140-0236 81 µM 1.98351359497921 0.0511293368469717 no 235 0.0236550450151933 233 990837 SGTC_247 mechlorethamine 29.705 µM 1.98071411021509 0.0513915018060148 no 236 0.0238116717402783 174 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links. SGTC_2564 betulinic acid 100 µM 1.97422247116739 0.0520035426086071 no 237 0.0241782259727125 278 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14 SGTC_1202 1988-0068 29.6 µM 1.97397185356187 0.0520272867885767 no 238 0.0241924717419154 249 2850480 SGTC_3225 9130819 49.47 µM 1.97391495628487 0.0520326785877375 no 239 0.0241957069157703 225 4547121 SGTC_2128 5255449 168.493 µM 1.96258786636535 0.0531149467762439 no 240 0.0248470408689386 266 736008 SGTC_3317 9138495 8.753 µM 1.94640878791833 0.0546916733050083 no 241 0.0258028274066607 242 17020139 SGTC_2824 7998404 51.95 µM 1.943852857018 0.0549441113112529 no 242 0.0259565988009792 218 837851 SGTC_2495 cafestol 54.53 µM 1.93994414960697 0.0553319368117668 no 243 0.0261932388828827 238 16667697 An anti-infammatory. SGTC_573 3702-0553 84.7 µM 1.9352305171224 0.0558024995212309 no 244 0.0264810072274361 213 1222756 SGTC_2224 6650123 117.647 µM 1.93488536466178 0.0558370798424732 no 245 0.0265021822667548 163 2908370 SGTC_236 1509-0011 5.31 µM 1.93396458010457 0.0559294146220489 no 246 0.0265587414546379 614 3107280 SGTC_3084 9116877 49.47 µM 1.93153954451903 0.0561731696348699 no 247 0.0267081819587205 162 27241325 SGTC_300 r073-0011 5.04 µM 1.92858550143687 0.0564712292169029 no 248 0.0268911701886929 272 2735780 SGTC_3187 9109394 49.47 µM 1.92795999041952 0.0565345021809839 no 249 0.0269300514555635 268 17098090 SGTC_2385 9074692 200 µM 1.92607027165005 0.0567259942188929 no 250 0.0270478000164049 273 17046906 SGTC_158 k038-0087 26.446 µM 1.92276660884949 0.057061993311426 no 251 0.0272546836753298 402 X158 SGTC_905 2-aminofluorene 215 µM 1.91984749051215 0.0573601843400071 no 252 0.027438583088985 258 1539 An established DNA mutagen. YPR165W RHO1 SGTC_2016 5121758 140 µM 1.91378142774861 0.0579837593529141 no 253 0.0278240447619625 313 2795203 SGTC_2356 9061756 188.97 µM 1.91316994813884 0.0580469122922189 no 254 0.0278631496907129 184 20104043 SGTC_2448 5185112 27.17 µM 1.90871195135456 0.0585089641821848 no 255 0.0281496302845279 218 5718189 SGTC_13 0199-0087 65 µM 1.90614232677654 0.0587766036769163 no 256 0.0283158712168884 225 4589825 SGTC_92 0063-0024 660.874 µM 1.90508641436371 0.0588868604821954 no 257 0.0283844195468114 270 3594437 SGTC_504 lovastatin 124 µM 1.89669354662169 0.0597690120980877 no 258 0.028934197966586 201 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1 SGTC_1273 0849-0096 14.1 µM 1.88732131243193 0.0607663017337479 no 259 0.0295585607849786 253 5286025 SGTC_1125 tnp00248 1.32998 µM 1.88691438989879 0.0608098949398411 no 260 0.0295859206572259 353 24207736 SGTC_856 0433-0016 11.3 µM 1.88641183697691 0.0608637666811757 no 261 0.0296197393467266 258 3911780 SGTC_2150 5556613 200 µM 1.88614189404947 0.0608927189268857 no 262 0.0296379180693708 265 743190 SGTC_1108 betulinic acid 729.144 nM 1.88149676434133 0.0613926127074344 no 263 0.0299521875073979 247 64945 Apoptosis-inducing agent of unknown mechanism. SGTC_715 0868-0130 184 µM 1.87662200037082 0.0619206604451922 no 264 0.0302849599355588 214 2876258 SGTC_789 1309-1135 70.6 µM 1.87584662383237 0.0620049771203937 no 265 0.0303381718698728 272 3092424 SGTC_3066 9117245 49.47 µM 1.87432516025272 0.0621706857960265 no 266 0.0304428108551214 248 17176980 SGTC_2099 5377090 177.372 µM 1.87313839073389 0.0623001812752901 no 267 0.0305246386057235 286 2243829 SGTC_1966 st070145 16.1 µM 1.87224767195873 0.0623975110161123 no 268 0.0305861732725455 252 3748532 SGTC_3121 9125696 49.47 µM 1.86960542858133 0.0626869292460835 no 269 0.0307693154386771 190 1235365 SGTC_1548 st061468 90.8 µM 1.86738189488254 0.0629312938628869 no 270 0.030924138149884 211 390799 SGTC_830 4076-0286 57.8 µM 1.86535295890018 0.063154919269087 no 271 0.0310659732327882 442 6866659 SGTC_3074 9116018 49.47 µM 1.86369332175579 0.0633383009809293 no 272 0.0311823918833129 219 17027303 SGTC_924 2046-0044 21.3 µM 1.86365458264035 0.063342586407524 no 273 0.0311851136222506 248 3623589 SGTC_2256 7954252 200 µM 1.86250046043642 0.0634703621138848 no 274 0.0312662903024062 192 2972920 SGTC_3189 9110682 49.47 µM 1.86127615187442 0.0636061275072553 no 275 0.0313525945756477 251 17122418 SGTC_578 3460-0051 92 µM 1.85996102862931 0.0637522150939216 no 276 0.0314455199307684 289 2876744 SGTC_1807 st050092 58.9 µM 1.85866323469614 0.0638966334327948 no 277 0.0315374439139031 259 5008496 SGTC_2357 9067248 200 µM 1.85526784291883 0.0642756758269072 no 278 0.0317789939325925 223 9150235 SGTC_1268 0828-0275 2.46 µM 1.84826285731562 0.0650631923802812 no 279 0.0322821630749705 268 745337 SGTC_1677 st019204 53.9 µM 1.84013942547336 0.0659858016419418 no 280 0.0328738851923228 265 3945625 SGTC_1473 k844-0725 134 µM 1.83947689794031 0.0660614922723637 no 281 0.0329225363979898 292 54682906 SGTC_688 0527-0193 473 µM 1.83944557475696 0.0660650724621708 no 282 0.0329248380132239 224 4007154 SGTC_1775 st081588 35.1725 µM 1.83339838576086 0.066759076521788 no 283 0.0333716737514926 286 1426443 YGL099W LSG1 SGTC_1133 3473-0247 50 µM 1.83296056089374 0.0668095415584255 no 284 0.033404218205769 330 711311 SGTC_3132 9126706 49.47 µM 1.8290989966765 0.067255916338697 no 285 0.0336923896285792 265 850858 SGTC_1934 st074720 32.6 µM 1.82053753993105 0.0682537917397067 no 286 0.034338592412638 340 17250992 SGTC_89 0302-0250 142.109 µM 1.81705815310493 0.0686625799578983 no 287 0.0346041047175033 296 4203518 YLR208W SEC13 SGTC_899 1083-0020 478 µM 1.8153635572168 0.0688623581402276 no 288 0.0347340288110248 304 767123 SGTC_743 1275-0778 158 µM 1.81275001883444 0.0691713498092353 no 289 0.0349351929904923 311 2849257 YMR203W TOM40 SGTC_2332 7982454 138.89 µM 1.81135894888409 0.069336247348985 no 290 0.0350426530676326 347 2981748 SGTC_251 melphalan 456.522 µM 1.80430476377789 0.0701771158576925 no 291 0.0355917717026815 336 460612 A DNA alkylator. SGTC_1502 4534-4282 27.7 µM 1.80220122981045 0.0704293721647851 no 292 0.0357568756480824 233 3278949 SGTC_1728 st035614 33.7865 µM 1.8002566644866 0.070663184468946 no 293 0.0359100600914553 367 15945546 SGTC_2425 5628681 7.85 µM 1.79764161155572 0.0709785553644415 no 294 0.0361169098490325 327 5714958 SGTC_1056 3448-1962 115 µM 1.79641593885663 0.071126740977715 no 295 0.0362141954032009 270 715507 SGTC_2727 riluzole 51.77 µM 1.79624216581498 0.0711477696055275 no 296 0.0362280056733203 236 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.  SGTC_630 4356-0227 183 µM 1.79224985715678 0.0716322027347092 no 297 0.0365464757498705 248 779312 SGTC_2810 7959871 45.46 µM 1.7918701246487 0.0716784115624293 no 298 0.0365768862836204 352 2974535 SGTC_2320 7373003 200 µM 1.78507028048583 0.0725097461016097 no 299 0.0371249589294501 285 5415828 SGTC_1167 k781-0610 148 µM 1.78464622243991 0.0725618341897713 no 300 0.0371593594721665 335 4525169 SGTC_1888 azatryptophan 97.5 µM 1.78354804864797 0.072696858779622 no 301 0.0372485668878824 240 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides SGTC_1077 5-fluorocytosine 377 nM 1.77871898433015 0.0732928946064442 no 302 0.0376429225826922 271 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_235 0330-0087 5 mM 1.77569419407196 0.0736681344209964 no 303 0.0378916674373989 327 46494818 YHR062C RPP1 SGTC_2071 5230951 39.92 µM 1.77346683574265 0.0739453865792239 no 304 0.0380756913052298 305 1799272 SGTC_2154 5570129 200 µM 1.76613063373641 0.0748642052144594 no 305 0.0386869675751867 313 673366 SGTC_48 0382-0018 55 µM 1.7614513380605 0.0754547944754068 no 306 0.0390810211799288 253 762596 SGTC_3203 9113543 49.47 µM 1.75803591467232 0.0758881030812205 no 307 0.0393706993110501 317 17018012 SGTC_419 nsc-638432 893 µM 1.75423150688555 0.0763729895086489 no 308 0.0396954232932358 299 368090 SGTC_2240 6690706 185.951 µM 1.75336393765409 0.0764838939197635 no 309 0.0397697784940535 258 805876 SGTC_2232 chlorophetanol 41.5365 µM 1.75225987773059 0.0766252068731674 no 310 0.0398645658746258 444 15907 An antifungal of unknown mechanism. YFR051C RET2 SGTC_733 4069-0007 56.1 µM 1.7473137337039 0.0772607216414607 no 311 0.0402914660494109 396 5717425 YNL287W SEC21 SGTC_200 k038-0079 37.545 µM 1.7433181038361 0.0777770253319109 no 312 0.0406390323742182 300 3436683 SGTC_54 0159-0055 9 µM 1.73998837720143 0.0782092799676918 no 313 0.0409305294251696 305 3319099 SGTC_1944 st076371 56.9 µM 1.73961624575426 0.0782577018736843 no 314 0.0409632123439986 314 24208455 SGTC_2043 5101342 149 µM 1.73497011693841 0.0788641736039414 no 315 0.0413730491810911 318 678451 SGTC_1392 3455-1037 33.9 µM 1.73170036686068 0.0792931129534234 no 316 0.0416634626497204 306 981132 SGTC_2691 st077356 60.2 µM 1.73017921888948 0.0794932643654911 no 317 0.0417991300018027 323 2839272 SGTC_2166 5933061 31.504 µM 1.72957513930941 0.0795728546436173 no 318 0.0418531054842139 323 2877375 SGTC_2507 purpurin 79.67 µM 1.72888053784592 0.0796644461078047 no 319 0.0419152389841664 340 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1 SGTC_2098 5376439 882.5 nM 1.72378851009315 0.0803383275647082 no 320 0.042373014796599 327 2844116 SGTC_3251 9135047 49.47 µM 1.72324030147357 0.0804111338306615 no 321 0.0424225392445262 229 17682963 SGTC_2777 climbazole 1.536 µM 1.71756232014902 0.0811681473452735 no 322 0.0429382390439933 357 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2 SGTC_1588 farnesol 29.9 µM 1.71483513447928 0.0815336539663769 no 323 0.0431877289606255 320 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_795 0685-0265 78 µM 1.71151084646887 0.0819808631114617 no 324 0.0434934253164479 339 302754 SGTC_1963 st076565 50.3 µM 1.70715481187992 0.0825696654015593 no 325 0.0438966407728449 302 4914280 SGTC_1780 st038448 24.544 µM 1.69912020358275 0.083664039745435 no 326 0.044648268698264 320 728868 YDL195W SEC31 SGTC_616 4092-0450 108 µM 1.69820177613001 0.0837898272962292 no 327 0.044734842726948 344 787165 SGTC_1522 st012842 45.6 µM 1.6950785991261 0.0842186396255218 no 328 0.0450302557042353 314 3491067 YOR116C RPO31 SGTC_2668 2',4'-dihydroxychalcone 15.08 µM 1.69483569202044 0.0842520596910275 no 329 0.0450532972908684 270 5357218 A potent inhibitor of glutathione S-transferases. SGTC_980 1473-0395 201 µM 1.69407965440597 0.0843561418669476 no 330 0.0451250739425538 263 768876 SGTC_3049 9092223 49.47 µM 1.69245358853035 0.0845803259569185 no 331 0.0452797610708792 294 8623917 SGTC_613 3914-0030 117 µM 1.69003409683728 0.0849147256519795 no 332 0.045510715821308 98 1145395 SGTC_1839 st053978 48 µM 1.68968025590222 0.0849637132217831 no 333 0.0455445712822611 315 3788398 SGTC_2512 diallyl trisulfide 49.23 µM 1.68875644046282 0.085091710863099 no 334 0.0456330572983795 253 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent SGTC_1868 st057644 42.7 µM 1.68317436768616 0.0858682015365542 no 335 0.04617067065768 366 688665 SGTC_1028 k015-0029 4.8 µM 1.68302345806784 0.0858892671015899 no 336 0.0461852751853746 375 4588309 SGTC_2033 5192550 145 µM 1.67991068677052 0.0863246438157614 no 337 0.0464873471092319 304 182073 SGTC_1316 1272-0050 65.9 µM 1.67988794272607 0.086327831039349 no 338 0.0464895600757722 295 7340392 SGTC_418 lividomycin a 100 µM 1.67894388472885 0.0864602037124722 no 339 0.0465814903343604 318 72394 An antibiotic. SGTC_1112 tnp00069 1.16933 µM 1.67228455555536 0.0873982664250534 no 340 0.0472341118373694 375 145826 SGTC_1430 4049-0248 69.1 µM 1.6711896739317 0.0875532207859821 no 341 0.0473421096092518 377 22774488 SGTC_514 4466-0038 2.65 nM 1.66880445333675 0.0878915014828424 no 342 0.0475780699365604 480 5722064 SGTC_2029 5175081 200 µM 1.66675040727844 0.0881835941418543 no 343 0.047782022577656 377 1380876 SGTC_1952 st077036 64.1 µM 1.66402931169024 0.0885716570437181 no 344 0.0480532859465507 364 2937007 SGTC_160 3453-0671 289.699 µM 1.66349788172333 0.088647593985467 no 345 0.0481064072614828 370 5322268 SGTC_3008 9078912 71.4286 µM 1.66188410287917 0.0888784868163146 no 346 0.0482680073681777 309 16648731 SGTC_1951 sophoraflavanone G 9.2 µM 1.66088516196932 0.0890216353540353 no 347 0.0483682564311422 370 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity. SGTC_2271 7849410 118.62 µM 1.66077445657146 0.0890375100284336 no 348 0.0483793765529163 316 972430 SGTC_2562 3',7'-dimethoxyflavone 64.92 µM 1.65733577531878 0.0895316517763835 no 349 0.0487258041048468 423 688664 SGTC_1331 1472-0049 76.2 µM 1.65581898335225 0.0897502632793089 no 350 0.0488792411206457 359 24051409 SGTC_2922 7999257 32.47 µM 1.65535670322173 0.0898169694150592 no 351 0.0489260815628455 300 2988377 SGTC_2404 5161160 200 µM 1.6552543430608 0.0898317447720096 no 352 0.0489364580340982 379 2831543 SGTC_2636 apigenin dimethyl ether 100 µM 1.65456549857881 0.0899312242284857 no 353 0.0490063334307564 404 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_1607 st000305 50.6 µM 1.65267803442197 0.0902042217734738 no 354 0.0491982035617566 344 5457690 SGTC_3331 9141060 1.957 µM 1.65146048890649 0.0903806504850405 no 355 0.0493222911148243 331 4906567 YPR165W RHO1 SGTC_1276 0871-0068 94.2 µM 1.64810940467402 0.0908675631433253 no 356 0.0496651113832406 313 3414906 SGTC_2795 7780010 54.55 µM 1.64740159631994 0.0909706562200899 no 357 0.0497377637363103 342 953673 SGTC_1165 k072-0275 30.3 µM 1.64716845137639 0.0910046330310273 no 358 0.0497617132455174 335 6153523 YGL055W OLE1 SGTC_1228 0124-0032 52.5 µM 1.64663252195431 0.0910827710881511 no 359 0.0498168007745933 361 X1228 SGTC_3302 9125395 16.351 µM 1.64445382341828 0.0914009358423495 no 360 0.0500412475534081 329 17599668 SGTC_2957 9076800 11.52 µM 1.63160088566012 0.0932946872163593 no 361 0.051381795773126 328 16459615 SGTC_1161 k007-0610 110 µM 1.62814912670887 0.0938081730771627 no 362 0.051746634438174 481 5843850 SGTC_1669 st015249 58.4 µM 1.6278358761715 0.0938548754771874 no 363 0.0517798455658399 304 722793 SGTC_1189 1431-2119 7.28 µM 1.62198019852352 0.0947310575014194 no 364 0.0524037940160347 406 3107275 SGTC_1294 1000-1494 117 µM 1.6057932578069 0.0971844406640804 no 365 0.0541596712626487 356 712797 YDL207W GLE1 SGTC_950 1165-0508 94.1 µM 1.60394168495318 0.097468020281723 no 366 0.0543634536385415 375 6148369 SGTC_344 k064-0035 6.43 µM 1.60265431871234 0.0976655456169183 no 367 0.0545054970990131 365 5088750 SGTC_162 k030-0015 37.8 µM 1.60100927124505 0.0979183782471263 no 368 0.0546874328506809 356 1809920 YMR134W ERG29 SGTC_1734 st037168 69.4 µM 1.60078299132332 0.0979531934309173 no 369 0.0547124960368523 374 708907 SGTC_2917 7979103 53.79 µM 1.59989677964669 0.0980896323383271 no 370 0.0548107419327743 426 2980565 SGTC_2842 9000675 19.48 µM 1.59641917795095 0.0986263804076893 no 371 0.0551976186006621 361 2989072 SGTC_1394 3474-0001 65.7 µM 1.59118286541939 0.0994386264158098 no 372 0.0557842139288462 319 5017666 YIL048W NEO1 SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM 1.59046536710842 0.099550303071506 no 373 0.0558649730901839 328 616764 SGTC_1476 4112-3294 3.34 µM 1.58275336893222 0.10075644608417 no 374 0.0567388444535864 360 704369 SGTC_1840 st055363 71 µM 1.57668200738871 0.10171346770052 no 375 0.0574343562292839 336 676033 SGTC_157 1348-1695 65.819 µM 1.57573414481855 0.101863473452132 no 376 0.0575435424745569 474 5380510 SGTC_2603 homopterocarpin 100 µM 1.57306992139064 0.102285967312596 no 377 0.0578513143734807 432 101795 A weak amylase inhibitor. SGTC_1506 4226-2149 212 µM 1.57227848641868 0.102411718656771 no 378 0.0579429900549449 433 991114 SGTC_2336 9001819 198.65 µM 1.57046637735492 0.102700068515603 no 379 0.0581533253041287 431 2989602 SGTC_1454 4239-0054 42.6 µM 1.56962984203793 0.102833380167695 no 380 0.0582506258613122 438 1340767 SGTC_2089 5281248 129.67 µM 1.56914376224594 0.102910900382782 no 381 0.0583072223420392 394 2737878 SGTC_29 0299-0004 12.984 µM 1.56864182323544 0.102990994380855 no 382 0.0583657107045998 283 16871 A napthoquinone isolated from Swertia calycina. SGTC_195 4234-0266 16.654 µM 1.56581838884885 0.103442371345216 no 383 0.0586955699842989 436 2303354 SGTC_329 k048-0121 21.3 µM 1.5640377912308 0.103727769348116 no 384 0.0589043468434687 359 6832902 SGTC_486 niguldipine 82 µM 1.56124756413928 0.104176141173987 no 385 0.0592326751793655 330 1236 A calcium channel blocker. SGTC_815 1582-0027 36.9 µM 1.55946052394379 0.104464044311982 no 386 0.0594437104532912 390 3128206 SGTC_2264 7948757 110.76 µM 1.55748510878862 0.104782966162816 no 387 0.0596776766858956 367 2971411 SGTC_337 1315-0038 354 µM 1.55092189205251 0.105847629434325 no 388 0.060460201681334 374 1626437 SGTC_87 0100-0052 35.5 µM 1.55055481782519 0.105907405041334 no 389 0.0605042034941676 631 200187 YGR083C | YDR527W GCD2 | RBA50 SGTC_347 4534-1311 26.2 µM 1.55021665527386 0.105962494159969 no 390 0.0605447617845639 393 2862016 SGTC_1374 2889-5571 141 µM 1.54816024625472 0.106297943903314 no 391 0.0607918599853238 454 2853281 SGTC_2655 perillic acid 100 µM 1.54735296267211 0.106429840681708 no 392 0.0608890785085404 317 5702197 An apoptosis inducer. SGTC_389 tpck 16.7 µM 1.54213365395881 0.107285441767898 no 393 0.0615205591823183 380 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.  SGTC_2876 9059903 25.97 µM 1.54176543731545 0.10734599023804 no 394 0.0615653019020383 406 6916095 SGTC_2198 6589944 200 µM 1.54006967888996 0.107625153760539 no 395 0.0617716848759452 304 5290268 SGTC_1784 st039334 36.3 µM 1.53825553954089 0.10792438442923 no 396 0.0619930729897081 404 3496984 SGTC_2485 5633444 17.78 µM 1.53775017290188 0.108007848016152 no 397 0.0620548554352962 409 5724239 SGTC_836 0330-0104 1.35 µM 1.53731304208554 0.108080079626799 no 398 0.062108334606608 393 46494820 SGTC_2951 9072950 58.06 µM 1.53550014878848 0.108380013785865 no 399 0.0623305102808892 429 16488155 SGTC_1608 st001473 40.5 µM 1.53262552040586 0.108856833736914 no 400 0.062684074886741 408 7292267 SGTC_974 1326-0144 138 µM 1.5253159260311 0.110076078609014 no 401 0.0635901586637265 453 5411856 SGTC_1732 st034308 51.822 µM 1.52381572979764 0.110327519297959 no 402 0.0637773745288418 408 830119 SGTC_3029 9088683 49.47 µM 1.52041888657392 0.110898369338023 no 403 0.0642028653456495 386 25236615 SGTC_1826 st055655 41.6 µM 1.51780349948707 0.111339332757328 no 404 0.0645319713242223 423 676168 SGTC_2171 5739187 198.077 µM 1.51701747892362 0.11147210353168 no 405 0.0646311355337553 351 2262761 SGTC_2276 7947513 42.08 µM 1.51554470163707 0.111721182886666 no 406 0.064817259440958 380 2105100 SGTC_316 k060-0003 58.6 µM 1.51379429641472 0.112017732749235 no 407 0.0650390098314451 402 6152314 SGTC_736 0958-0254 92.6 µM 1.51277387854435 0.112190869184975 no 408 0.0651685530626694 441 6812352 SGTC_2108 5365811 200 µM 1.51187659103396 0.112343271801529 no 409 0.0652826301058129 417 780283 SGTC_1841 st054148 70 µM 1.50923510528284 0.112792781832223 no 410 0.0656193559823459 384 675442 SGTC_1778 st046819 58.9 µM 1.50805430796358 0.112994136645481 no 411 0.0657703140799629 475 671715 SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM 1.50784063452479 0.113030600586554 no 412 0.0657976597320659 320 4620898 SGTC_37 0566-0070 1.56 µM 1.50515573902447 0.11348950101632 no 413 0.0661420207373672 463 1626686 SGTC_888 0916-0002 6.97 µM 1.50503242335368 0.113510609908369 no 414 0.0661578705054443 405 2802138 YIL048W NEO1 SGTC_1683 st010134 710 nM 1.49748588136989 0.114807741803345 no 415 0.06713343828798 430 3818134 SGTC_2537 larixol 68.93 µM 1.49261172406254 0.115651117798873 no 416 0.0677694263143403 458 6708759 SGTC_2267 7931562 200 µM 1.49167486776276 0.115813725113877 no 417 0.0678922003567492 394 934880 SGTC_2012 4023501 200 µM 1.48742859845331 0.116552772769946 no 418 0.0684508241608757 408 3477460 SGTC_2785 7756463 72.73 µM 1.48571001928568 0.116852833972495 no 419 0.0686779196585797 429 2201551 SGTC_1533 dihydroergotamine mesylate 29.4 µM 1.48443416481533 0.117075950011941 no 420 0.0688468883424499 444 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release. SGTC_3279 9140807 49.47 µM 1.47880126218929 0.118064616051881 no 421 0.069596719212752 407 45595718 SGTC_1709 st033179 39.1045 µM 1.4682714381541 0.11992857726249 no 422 0.0710152530165083 459 573381 SGTC_1159 4092-0538 61.2 µM 1.46808231276346 0.119962244308649 no 423 0.0710409326970122 479 717301 SGTC_681 1642-0006 26.6 µM 1.46733064161163 0.120096118466414 no 424 0.0711430660429486 371 4446530 SGTC_2939 9044578 71.43 µM 1.46649878718032 0.12024439612128 no 425 0.0712562256838997 421 2653634 SGTC_2229 7354935 190 µM 1.46534720137318 0.120449878542191 no 426 0.0714131073264434 356 318112 SGTC_3272 9137413 49.47 µM 1.46489355690636 0.120530892140149 no 427 0.0714749804808367 420 17614870 SGTC_2762 leflunomide 42.06 µM 1.4595965946514 0.121479684737488 no 428 0.0722004878592257 490 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1 SGTC_309 k408-0051 1.48 µM 1.45783442721147 0.121796485175911 no 429 0.0724430931905683 540 3640463 SGTC_3276 9139060 49.47 µM 1.45780596114759 0.121801607531732 no 430 0.0724470173581377 346 4870619 SGTC_698 k064-0052 127 µM 1.45400005539304 0.122487828593081 no 431 0.0729731454180506 364 5088751 SGTC_1528 arabinosylhypoxanthine 74.6 µM 1.45314464499237 0.122642435408691 no 432 0.073091798809564 491 804 An inhibitor of viral and cellular DNA polymerases. SGTC_2066 5222451 176 µM 1.45264667761295 0.122732501015062 no 433 0.0731609394812043 520 2281147 SGTC_108 0509-0257 621.132 µM 1.45208476617715 0.122834187655527 no 434 0.0732390185984486 495 536624 SGTC_1572 epiandrosterone 68.9 µM 1.44941280773288 0.123318528589809 no 435 0.0736111670195745 481 441302 A steroid. SGTC_1440 4100-1550 40 µM 1.44773850976066 0.123622706540229 no 436 0.073845097764776 386 742806 SGTC_2213 7173844 200 µM 1.44511229795756 0.124100881052813 no 437 0.074213172596276 437 892728 SGTC_424 splitomicin 100 mM 1.44376008775465 0.12434759238276 no 438 0.0744032363025214 440 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_1675 st018485 24.5 µM 1.43939984235765 0.125145456435213 no 439 0.0750186345047067 447 3323024 SGTC_1319 1306-0155 43.7 µM 1.43920138249263 0.125181856691871 no 440 0.0750467369116902 511 3122360 SGTC_106 0092-0003 11.579 µM 1.43758673481232 0.125478279956049 no 441 0.0752756734651826 351 1072148 SGTC_2916 7875993 68.79 µM 1.43043748817514 0.126796651279911 no 442 0.0762957476290275 459 1299250 SGTC_1384 3089-0840 101 µM 1.4254520873651 0.127721682671368 no 443 0.0770132802897159 415 1069836 SGTC_2889 9059656 51.95 µM 1.42492845448736 0.127819113248823 no 444 0.077088941729462 494 3949838 SGTC_71 0417-1750 47.813 µM 1.42081059145812 0.128587110239743 no 445 0.0776859153803401 498 6811472 SGTC_2100 5377183 190 µM 1.41961392111514 0.12881089307854 no 446 0.0778600551700759 492 2844202 SGTC_1479 0549-0158 134 µM 1.4189193297685 0.128940908690312 no 447 0.0779612680774894 514 5440202 SGTC_1467 k284-1082 293 µM 1.41437580267515 0.129793623986848 no 448 0.0786257954378412 473 3334705 SGTC_2767 sibutramine 71.45 µM 1.41330638283646 0.129994895865758 no 449 0.078782829033915 474 64765 A serotonin-norepinephrine reuptake inhibitor.  SGTC_1762 st045503 25.4615 µM 1.4121130219799 0.130219749198888 no 450 0.0789583425454704 485 4645554 SGTC_1743 st037606 46.3785 µM 1.41162299503868 0.130312158084553 no 451 0.0790304989617998 457 590142 YLR208W | YDL195W SEC13 | SEC31 SGTC_1867 st057372 64 µM 1.40870922378923 0.13086257154663 no 452 0.0794605831910906 470 688837 SGTC_2665 lovastatin 100 µM 1.40585999601246 0.131402344386865 no 453 0.0798828511527817 453 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1 SGTC_317 4495-0002 170 µM 1.40260202615014 0.132021432907587 no 454 0.0803677736454001 426 15991618 SGTC_3348 9149464 3.537 µM 1.39787386834705 0.132923463652951 no 455 0.0810754735512128 477 1951442 SGTC_1965 Pectolinarigenin 58.4 µM 1.39725389587468 0.133042054980158 no 456 0.0811686173159951 467 5320438 An anti-inflammatory. SGTC_1198 1612-1005 86.7 µM 1.39440616942294 0.133587717279576 no 457 0.0815974930728355 487 6998509 SGTC_665 3914-0008 307 µM 1.38943555873489 0.134543835669342 no 458 0.0823501718697871 473 1069549 SGTC_714 4296-0578 26.1 µM 1.38597603205443 0.135212056524644 no 459 0.0828771111385131 371 1589775 SGTC_2588 indole-3-carbinol 100 µM 1.38426099620681 0.13554416446196 no 460 0.0831392761687999 542 3712 Induces cell cycle arrest. SGTC_1753 st043925 64 µM 1.38411961736486 0.135571566667486 no 461 0.0831609155135624 508 670181 SGTC_79 0052-0007 94.094 µM 1.38339438869977 0.135712190969442 no 462 0.083271985084522 489 2801472 SGTC_2561 acetosyringone 100 µM 1.38276060981935 0.135835164628512 no 463 0.0833691403061171 559 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent. SGTC_2294 7971431 200 µM 1.38236006137396 0.135912923359828 no 464 0.0834305863622333 412 5741572 SGTC_3191 9110352 49.47 µM 1.37646811521098 0.137060252678863 no 465 0.0843383761126393 451 17122424 SGTC_413 propylparaben 100 µM 1.37609447853804 0.137133232825149 no 466 0.084396192383015 484 7175 A pharmaceutical preservative. SGTC_2571 chrysanthemic acid 100 µM 1.37342764248159 0.137654900374038 no 467 0.084809720617947 461 2743 An insecticide. SGTC_2244 6635614 200 µM 1.37306448762262 0.137726042786605 no 468 0.0848661499133745 354 836499 SGTC_208 k072-0098 12.366 µM 1.37035023765192 0.138258561691917 no 469 0.0852887989497314 591 5948901 SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM 1.36562716806889 0.139188541081716 no 470 0.0860280073865769 388 279621 SGTC_285 1486-1325 46 µM 1.36464900061321 0.139381674595016 no 471 0.0861816979702777 533 22310230 SGTC_1693 xanthone 101.9 µM 1.36329783541339 0.139648754075946 no 472 0.086394331974957 529 7020 An insecticide. SGTC_367 0335-0881 7.1 µM 1.36287023895689 0.139733347816695 no 473 0.0864617048385335 541 23828853 SGTC_2088 5278280 127.392 µM 1.36190622861537 0.139924191029892 no 474 0.0866137401296712 541 791502 SGTC_911 3456-4043 236 µM 1.3617644564446 0.139952272319046 no 475 0.0866361160423931 524 914281 SGTC_1484 3473-2379 286 µM 1.36016875826762 0.140268601748648 no 476 0.0868882632696344 604 671917 SGTC_3304 9125678 46.087 µM 1.35971720917465 0.14035820442018 no 477 0.0869597150709215 529 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2 SGTC_2349 9023730 187.07 µM 1.35900817162327 0.140498979962038 no 478 0.0870719996475511 493 4126287 SGTC_2110 5483698 200 µM 1.35883212524353 0.140533947860606 no 479 0.0870998954705566 486 2848765 YHR062C RPP1 SGTC_2968 9090663 33.37 µM 1.35841891253432 0.140616047051947 no 480 0.0871653982330555 506 25236811 SGTC_1864 st057645 30.4 µM 1.35839390588349 0.140621016544259 no 481 0.0871693634846366 459 688666 SGTC_2122 5258151 111.688 µM 1.35733724827842 0.140831111694229 no 482 0.0873370385624167 505 2173356 SGTC_1565 sinapyl alcohol 95.1 µM 1.35441672483012 0.141412906460145 no 483 0.0878017323678422 481 5280507 A phenol propionate derived from cinnamic acid. SGTC_1352 1496-0991 99 µM 1.35368811342855 0.141558305979394 no 484 0.0879179509842239 485 3000039 SGTC_2316 5844804 197.44 µM 1.3517763481437 0.141940293582361 no 485 0.0882234362892844 627 776813 SGTC_2683 piperine 63.03 µM 1.34956417288447 0.14238317600457 no 486 0.0885779114053935 481 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_2975 9084847 53.72 µM 1.34760699786285 0.142775785416173 no 487 0.0888924093227224 516 27211724 SGTC_1756 st041558 35.5 µM 1.34683585568188 0.142930677364286 no 488 0.0890165519926681 558 3955792 SGTC_1822 st052468 42 µM 1.34561636961492 0.143175855563668 no 489 0.0892131348358615 481 2873678 SGTC_197 4544-0043 41.561 µM 1.34291018412127 0.143720949517015 no 490 0.0896505291853247 560 896523 SGTC_2580 diallyl disulphide 81.36 µM 1.33629030989537 0.14506025511071 no 491 0.0907272012663021 495 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.  SGTC_3046 9092212 49.47 µM 1.33491592418768 0.145339364853342 no 492 0.0909519326497353 491 25236637 SGTC_600 1495-0418 41.6 µM 1.33417323061231 0.145490341055081 no 493 0.0910735452292924 491 5377768 SGTC_1029 k015-0030 64.7 µM 1.33056881351689 0.146224551708549 no 494 0.091665464914913 516 2208316 SGTC_1150 3909-7983 10.9 µM 1.32702892838134 0.146948035300735 no 495 0.0922495567398097 558 23965914 SGTC_25 0118-0223 35.662 µM 1.32673005269524 0.147009229388357 no 496 0.0922989979652772 504 5333628 SGTC_3033 9090887 49.47 µM 1.32628033917296 0.147101339362889 no 497 0.0923734283472747 558 19325384 SGTC_1144 3486-0183 12.5 µM 1.32523859001382 0.147314858225833 no 498 0.0925460149033919 579 6744069 SGTC_2059 5238311 157 µM 1.32487453066123 0.147389525468274 no 499 0.0926063848215921 510 703021 SGTC_1074 carmofur 3.8 µM 1.32410068036473 0.147548323568479 no 500 0.0927348048311182 576 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_209 4077-0173 175.592 µM 1.32276669494045 0.14782233329571 no 501 0.092956488058634 411 15993494 SGTC_1901 st060216 58.6 µM 1.32235944408376 0.147906053247926 no 502 0.0930242434671209 542 688792 SGTC_2037 5169046 200 µM 1.32187627790931 0.148005420533426 no 503 0.0931046764475043 494 5718022 SGTC_1628 st004252 77.7 µM 1.32177531961235 0.148026189119161 no 504 0.0931214895295423 561 692968 SGTC_180 1486-1293 102.781 µM 1.31992541283626 0.148407087086893 no 505 0.0934299609668967 530 4140536 SGTC_2381 9035592 200 µM 1.31739451000153 0.148929263951675 no 506 0.0938532101059204 450 4749657 SGTC_582 0987-0078 156 µM 1.31693620910518 0.149023951886136 no 507 0.093930003999656 675 1625765 SGTC_2467 5474540 200 µM 1.31606584232994 0.149203885989115 no 508 0.0940759721891983 535 5413519 SGTC_955 1216-0110 33 µM 1.31436380865718 0.149556172730289 no 509 0.0943619017899936 587 3619719 SGTC_377 3970-0964 33.1 µM 1.31133878016923 0.150183661745641 no 510 0.0948716659920976 637 16481235 SGTC_1336 1486-0901 104 µM 1.31070836585451 0.150314650760102 no 511 0.0949781555912507 528 5006114 SGTC_2453 5731132 22.18 µM 1.3058735222159 0.151321776677321 no 512 0.0957977860926622 587 1362040 SGTC_1045 1348-1485 165 µM 1.30463148434085 0.151581223234601 no 513 0.0960091810502355 598 6810614 SGTC_1960 st011366 51.8 µM 1.30447951552195 0.151612987958302 no 514 0.0960350696912656 523 3972846 SGTC_2624 nerol 100 µM 1.30445984933853 0.151617098933316 no 515 0.0960384202980985 521 637566 A natural product oil. SGTC_2234 tolnaftate 200 µM 1.30249253032568 0.152028717352384 no 516 0.0963740348983177 454 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7 SGTC_2788 5282734 71.43 µM 1.293757801234 0.153865224135974 no 517 0.0978745464745165 620 743706 SGTC_3349 9149703 23.001 µM 1.29358703288697 0.153901274491312 no 518 0.0979040519320871 520 4910494 SGTC_2974 9094440 9.66 µM 1.29279998175095 0.154067498564554 no 519 0.0980401233640189 594 25236134 SGTC_2468 5987765 72.9 µM 1.29236008159139 0.154160456574365 no 520 0.0981162370198127 565 26772094 SGTC_3346 9158254 43.5805 µM 1.29064788113623 0.154522625337712 no 521 0.0984129024243239 552 17639500 SGTC_3309 9129340 25.759 µM 1.29032622456421 0.154590725609938 no 522 0.0984687076481927 587 17158987 SGTC_172 1112-0046 2.638 µM 1.28892232939417 0.154888186736417 no 523 0.0987125451555403 492 2802135 YIL048W NEO1 SGTC_804 1595-0054 20.9 µM 1.28624010277184 0.155457554695638 no 524 0.0991796396252346 529 761523 Stimulates phospholipase C. SGTC_2622 2-methoxyxanthone 59.94 µM 1.28561614973305 0.15559020166577 no 525 0.0992885288426773 584 71034 A hepatoprotective. SGTC_1514 1189-1591 158 µM 1.2844284418811 0.15584290424345 no 526 0.0994960432787171 606 767698 YMR146C TIF34 SGTC_741 4582-0002 126 µM 1.28388950590636 0.155957660118238 no 527 0.0995903098014158 544 2912688 SGTC_2941 9056145 11.23 µM 1.27633293607948 0.157572548180865 no 528 0.100918926039252 459 2119517 SGTC_470 aa-861 153 µM 1.2760133605197 0.157641084851723 no 529 0.100975398113617 609 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor. SGTC_3120 9124077 49.47 µM 1.27527345234437 0.157799841861883 no 530 0.101106235407788 557 18774327 YGL155W CDC43 SGTC_690 glyoxal 20.3 µM 1.27482885759913 0.157895285986823 no 531 0.101184912098335 583 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins. SGTC_223 busulfan 5 mM 1.2729350261758 0.158302272002292 no 532 0.101520549435405 454 2478 A DNA alkylator. SGTC_3227 9130768 49.47 µM 1.27020011831768 0.158891219714682 no 533 0.102006677763217 549 17720899 SGTC_769 0302-0231 76 µM 1.2678718837141 0.159393722666617 no 534 0.102421853128218 666 571869 YER009W NTF2 SGTC_150 3970-0969 77.2 µM 1.26696046060559 0.159590718221745 no 535 0.102584714090477 652 6615640 SGTC_775 4577-0580 57.3 µM 1.26488361999237 0.160040202815193 no 536 0.102956524975354 582 2006902 SGTC_2818 7996756 12.99 µM 1.26398759061416 0.160234383227022 no 537 0.103117240518161 462 2241621 SGTC_2731 amoxapine 43.43 µM 1.26364401567745 0.160308880903853 no 538 0.103178913844289 440 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine. SGTC_2197 6588183 93.1375 µM 1.2630898998371 0.160429078049138 no 539 0.103278436687959 513 884136 SGTC_2409 alverine citrate 63.97 µM 1.26207813540126 0.160648698834161 no 540 0.103460336007232 575 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_758 0868-0029 16 µM 1.26109805810495 0.160861628525532 no 541 0.103636760092116 572 762687 SGTC_1344 1488-0097 29.1 µM 1.25904254985438 0.161308802407528 no 542 0.104007481702651 562 747966 SGTC_806 3966-4455 5.86 µM 1.2550559603325 0.162178390163922 no 543 0.104729223045692 503 714982 SGTC_2465 5809242 33.21 µM 1.25422446074547 0.162360147715644 no 544 0.104880215710222 549 2731748 SGTC_1824 st053723 68.6 µM 1.25125926126479 0.163009389910626 no 545 0.105419951735452 579 675225 SGTC_148 3253-0744 288.01 µM 1.25012979648378 0.16325713395451 no 546 0.105626068380964 559 6893655 SGTC_1880 MG-132 525 µM 1.24905495194636 0.16349312430859 no 547 0.105822487798186 537 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1 SGTC_526 4469-0568 170 µM 1.24790933491914 0.163744897084434 no 548 0.106032130848768 576 2901964 SGTC_3156 9099931 49.47 µM 1.2474224425091 0.163851977821969 no 549 0.106121320905531 611 18111053 SGTC_1765 st044815 90.4 µM 1.2454160691444 0.164293712651055 no 550 0.106489424775678 575 645695 SGTC_2904 7225135 42.03 µM 1.24362284039403 0.164689173194999 no 551 0.106819202956404 602 4446116 SGTC_3217 9129673 49.47 µM 1.24336593457758 0.164745879071675 no 552 0.106866508707097 576 17248312 SGTC_2394 5221648 200 µM 1.24106675596975 0.165253931369217 no 553 0.107290544586669 655 788586 SGTC_1363 1636-0063 10.4 µM 1.2402369435143 0.165437544788221 no 554 0.10744388382242 623 6072185 SGTC_508 roscovitine 141 µM 1.23660579467455 0.166242564348267 no 555 0.108116733792856 590 160355 A CDKinase inhibitor. SGTC_1647 st011722 22.4 µM 1.23414646697793 0.166789227785233 no 556 0.108574165593787 552 2854783 SGTC_263 alizarin 107.927 µM 1.23410219024146 0.166799080307773 no 557 0.108582413747977 678 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. SGTC_1987 st072290 61.9 µM 1.22863565445261 0.168018386233218 no 558 0.109604220619654 621 54697379 SGTC_2247 cerulenin 830 nM 1.22831923149546 0.168089139285252 no 559 0.10966357719152 600 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12 SGTC_1124 fisetin 1.16336 µM 1.22757568557616 0.168255473664303 no 560 0.10980314694804 545 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster. SGTC_2813 7971799 71.43 µM 1.22419063139135 0.16901406236219 no 561 0.110440161270953 571 2234054 SGTC_2733 amorolfine 100 µM 1.22382342525598 0.169096484916435 no 562 0.110509422704308 483 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_3245 9134821 49.47 µM 1.22287426506169 0.169309651597358 no 563 0.110688594997478 603 17014901 SGTC_1694 st024011 44.9 µM 1.22146094684374 0.169627380481482 no 564 0.110955771699283 651 2787533 SGTC_1892 st058411 7.36 µM 1.21890965353212 0.170201905958631 no 565 0.11143924263779 680 3934738 SGTC_2058 5236698 133 µM 1.21821459738621 0.170358641436255 no 566 0.111571216947144 587 766665 SGTC_322 k048-0136 19.3 µM 1.2181746414016 0.170367654338207 no 567 0.11157880701753 580 6823282 SGTC_553 k007-0256 45.7 µM 1.21697682523517 0.170637988458081 no 568 0.111806516696329 613 6287000 SGTC_703 3875-0075 71.8 µM 1.2139391306854 0.17132479367197 no 569 0.112385484423514 645 2850814 SGTC_3286 9117135 37.221 µM 1.21381253991409 0.171353453419634 no 570 0.112409658329975 582 3438150 SGTC_355 1311-2252 105 µM 1.21363117851391 0.171394518403508 no 571 0.112444297766544 611 5338538 SGTC_709 3807-1509 243 µM 1.2094157534242 0.172350773260651 no 572 0.113251579707005 593 1886677 YPL242C IQG1 SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM 1.20869946270226 0.172513599037632 no 573 0.113389164093337 601 6312947 SGTC_1786 berberine 21.6 µM 1.20786291119789 0.17270388640071 no 574 0.113549998910291 608 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_3239 9133757 49.47 µM 1.20463442534836 0.173439512479996 no 575 0.114172230446778 604 17036923 SGTC_1393 3470-5649 58.2 µM 1.20419404508421 0.173540009605825 no 576 0.114257293538424 505 4108395 SGTC_596 1155-0152 116 µM 1.20356046866203 0.173684660121705 no 577 0.114379753223799 671 280313 SGTC_2401 5128683 200 µM 1.2032459833029 0.173756488098729 no 578 0.114440572654921 562 708373 SGTC_1486 3970-0793 4.53 µM 1.20240967587283 0.173947591362644 no 579 0.114602421099619 635 2844330 SGTC_165 k038-0023 64.381 µM 1.20240536119099 0.173948577650046 no 580 0.114603256531166 635 46368543 SGTC_447 ml7 120 µM 1.19800588001485 0.174956099226024 no 581 0.115457363937668 628 4216 Selective myosin light chain kinase inhibitor. SGTC_2181 6316240 54.2555 µM 1.19738090827264 0.175099523276535 no 582 0.115579060795041 568 12779990 SGTC_122 0236-0016 402.397 µM 1.19086645853705 0.176598955001129 no 583 0.116853006935307 697 6808838 SGTC_2304 7443016 91.4 µM 1.18986392498813 0.176830427144243 no 584 0.117049939717477 559 939854 SGTC_2260 7964312 200 µM 1.18977971935086 0.176849877872596 no 585 0.117066491360159 573 231951 SGTC_2963 9082507 9 µM 1.18909583423525 0.177007899136313 no 586 0.117200978732181 592 16459611 SGTC_2266 7929956 200 µM 1.18727738353839 0.177428511552673 no 587 0.117559113000351 648 2967153 SGTC_2900 5328528 85.29 µM 1.18568558582587 0.177797215992029 no 588 0.117873244487277 673 795359 SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM 1.18401044805076 0.178185745835081 no 589 0.118204463490274 715 5024745 SGTC_463 ikarugamyin 104 µM 1.18392917850587 0.17820460901632 no 590 0.118220549349102 564 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis. SGTC_2013 4024628 200 µM 1.18300266830251 0.178419746919279 no 591 0.11840404495913 575 5230760 SGTC_2503 beta-caryophyllene alcohol 24.72 µM 1.1826030234123 0.178512595916621 no 592 0.118483256860844 556 61125 An anti-inflammatory. SGTC_305 1682-2595 20.8 µM 1.18227901503518 0.17858789471279 no 593 0.118547504659262 650 226033 SGTC_2695 st077686 51.995 µM 1.18206489199543 0.17863766738695 no 594 0.118589976742947 597 2876092 SGTC_1545 lovastatin 49.4 µM 1.18186188155664 0.178684865014844 no 595 0.118630254530673 664 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12 SGTC_2478 5763493 32.33 µM 1.18132002598015 0.178810878742154 no 596 0.118737807383669 660 1365576 YLR208W SEC13 SGTC_3122 9126309 49.47 µM 1.18066887006167 0.17896238530128 no 597 0.118867146355972 613 17591206 SGTC_46 0329-0187a 2.197 µM 1.1805161663495 0.178997927059305 no 598 0.118897492262786 731 46494817 SGTC_920 mycophenolic acid 780.421 nM 1.18023374143681 0.179063673103142 no 599 0.11895363131407 630 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_2926 9010726 65.15 µM 1.17961010904332 0.179208903062912 no 600 0.119077660223638 628 2994293 SGTC_3091 9116372 49.47 µM 1.17572175651789 0.180116083127777 no 601 0.119853040832883 585 17169793 SGTC_117 lucigenin 22.078 µM 1.17525072198932 0.180226174240324 no 602 0.119947211516736 686 65100 An acridine derivative; a dye stuff and potential carcinogen. SGTC_1240 0356-0016 42.1 µM 1.17480164375475 0.180331173001644 no 603 0.120037041186512 648 4305613 SGTC_2867 9039098 71.43 µM 1.17106988387372 0.181205178115801 no 604 0.120785344018139 643 6463460 SGTC_3123 9126162 49.47 µM 1.17077495125266 0.181274366411945 no 605 0.120844624418889 630 25239884 SGTC_3078 9116413 49.47 µM 1.16933978995589 0.181611277226004 no 606 0.121133378933584 585 17177322 SGTC_2484 5809818 12.04 µM 1.16761665541101 0.182016308421986 no 607 0.121480714427669 621 2870548 SGTC_2307 7538926 6.34 µM 1.16230203170682 0.183269090391703 no 608 0.122556400819094 672 96582 SGTC_2017 5132927 60.65 µM 1.16207264238716 0.183323283633764 no 609 0.122602979475084 641 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis SGTC_120 rhodamine 6G 52.259 µM 1.16139036898721 0.183484529819674 no 610 0.122741591921698 751 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase SGTC_1883 5-benzylidenerhodanine 20 µM 1.16001207743215 0.183810540162797 no 611 0.123021944448935 715 1273210 SGTC_2714 st079313 56.9 µM 1.15914547611181 0.184015703914855 no 612 0.123198445889946 635 2939799 SGTC_1311 1190-0148 100 µM 1.15832755238227 0.184209474213615 no 613 0.123365195844741 765 1961333 SGTC_2773 thioridazine 9.09 µM 1.15639038258712 0.184668905907942 no 614 0.123760756820217 661 5452 An antipsychotic. SGTC_642 0335-0876 158 µM 1.15274260153789 0.185535969063942 no 615 0.124508024969619 665 6812350 SGTC_2893 9048488 25.97 µM 1.14706233078052 0.18689116769938 no 616 0.125677930449792 637 6467338 SGTC_2435 5706476 10.6 µM 1.1469588366918 0.186915915995617 no 617 0.125699316937874 708 5725375 SGTC_1645 Cervolide 78 µM 1.14654331978881 0.187015297981205 no 618 0.125785206795135 624 23173 A fragrance. SGTC_1258 0671-0043 57.1 µM 1.14343257032974 0.187760354984004 no 619 0.126429518005177 666 4298767 SGTC_1234 0326-0494 15.5 µM 1.14057558749229 0.18844624491747 no 620 0.12702329053948 671 1547813 SGTC_1168 k815-0004 80.5 µM 1.14047918667196 0.188469415255004 no 621 0.127043359509013 662 642433 SGTC_264 promethazine 12.5 mM 1.14047169580668 0.188471215789147 no 622 0.127044919068913 795 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3 SGTC_3088 9117578 49.47 µM 1.13956474030932 0.188689293606351 no 623 0.127233841042466 655 678341 SGTC_1022 4477-0945 21.3 µM 1.13822363667558 0.189012047433189 no 624 0.127513555605088 676 4648966 SGTC_931 2812-0076 566 µM 1.13450348747195 0.189909127711847 no 625 0.128291705845921 697 3450959 SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM 1.13310939497455 0.190245973633414 no 626 0.12858415824344 751 688761 SGTC_1911 st060208 74.3 µM 1.13198800057933 0.190517195403677 no 627 0.12881973961742 708 688783 SGTC_1014 4130-3005 69.3 µM 1.12823661632966 0.191426233791172 no 628 0.129610001903888 687 743608 SGTC_2584 androsterone 48.74 µM 1.1265906221446 0.191825929922079 no 629 0.1299578029506 836 2754130 A steroid. SGTC_1876 myriocin 605 nM 1.12373670045034 0.192520156496377 no 630 0.130562371030278 694 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1 SGTC_1613 st002381 52.1 µM 1.12309781855141 0.192675776921749 no 631 0.130697976256654 674 551167 SGTC_1591 genipin 88.4 µM 1.12241978494893 0.192841018070968 no 632 0.130841998053662 651 442424 A DNA cross-linking agent. SGTC_2168 5727979 200 µM 1.12195532565349 0.192954259733227 no 633 0.130940717597364 617 695210 SGTC_3080 9117754 49.47 µM 1.12000888040984 0.193429271835634 no 634 0.131354988910792 752 9550191 SGTC_2979 9012552 45.46 µM 1.11935366254197 0.193589332106156 no 635 0.131494645461527 625 17100905 SGTC_2680 butyl paraben 22.24 µM 1.11741694738622 0.194062915717326 no 636 0.131908046127853 663 7184 An antifungal and steroid mimetic. SGTC_2789 5281112 71.43 µM 1.11732933064439 0.194084357253142 no 637 0.131926769492634 676 765948 SGTC_777 1315-0167 517 µM 1.11700741953577 0.194163147608963 no 638 0.131995576412955 646 4221767 SGTC_1420 4'-methoxyflavone 42 µM 1.11670528398937 0.194237115456748 no 639 0.132060178916094 705 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13 SGTC_2956 9076196 2.52 µM 1.11618077674333 0.19436556437275 no 640 0.13217238062148 683 16423868 SGTC_2888 9058547 12.99 µM 1.11576758949333 0.194466788046686 no 641 0.132260815209461 596 16476514 SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM 1.11501723285237 0.194650694373665 no 642 0.132421518535844 740 6708784 An antioxidant flavonoid SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM 1.11496263166581 0.194664080810678 no 643 0.132433217681364 693 7104 SGTC_701 4424-0219 185 µM 1.11380226894424 0.194948696471058 no 644 0.132682011691066 768 2911779 SGTC_638 3970-0837 4.09 µM 1.11314725271044 0.195109471592526 no 645 0.132822596154214 701 4118451 YLR208W SEC13 SGTC_2251 lansoprazole 556 µM 1.11263093072021 0.195236260703442 no 646 0.132933485296837 545 3883 Gastric proton pump inhibitor. YBR192W RIM2 SGTC_2560 caryophyllene 100 µM 1.11227426245159 0.195323874142757 no 647 0.133010123233318 750 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor. SGTC_1265 0819-1001 68.8 µM 1.11064725445649 0.195723841906083 no 648 0.133360107081435 658 3106768 SGTC_1443 4112-3303 14 µM 1.10953858162617 0.195996671801975 no 649 0.133598955057452 711 704433 SGTC_914 3820-6779 408 µM 1.10614668888087 0.196832803854919 no 650 0.134331516560108 666 2893481 SGTC_2719 novobiocin 32.65 µM 1.10438996382373 0.197266700076177 no 651 0.134712006238441 630 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication. SGTC_2713 st079149 53.4 µM 1.1014188748397 0.198001849404971 no 652 0.135357197171463 735 3103253 SGTC_983 1491-0821 12.2 µM 1.09946287803111 0.198486732076454 no 653 0.135783108705513 708 46495113 SGTC_2178 5812956 200 µM 1.09919697535418 0.198552703401146 no 654 0.135841078882543 687 5403383 SGTC_2319 6033012 152.6 µM 1.09919083275586 0.198554227556183 no 655 0.135842418247622 643 847246 SGTC_1519 esterone 74 µM 1.09652604285087 0.199216103903292 no 656 0.136424316408668 700 698 A steroid. SGTC_3158 9100007 49.47 µM 1.09633283063169 0.199264145265269 no 657 0.13646657348717 628 19297233 SGTC_1267 0828-0272 9.49 µM 1.09610888464661 0.199319837171116 no 658 0.136515563490695 755 745334 SGTC_937 3122-0005 46.7 µM 1.09549338737701 0.199472950103515 no 659 0.136650270472546 755 759535 SGTC_2792 7535235 81.82 µM 1.09540861006753 0.199494045105457 no 660 0.1366688318502 649 1281891 SGTC_3274 9138298 49.47 µM 1.09507236720001 0.199577725102614 no 661 0.136742466766731 735 17015756 SGTC_2243 6634756 200 µM 1.09382166710235 0.199889169359056 no 662 0.137016599685743 671 885676 SGTC_3273 9137859 49.47 µM 1.09358372996613 0.199948452572513 no 663 0.137068794084004 705 2377234 SGTC_290 2043-6722 48.1 µM 1.09073403521191 0.200659289350876 no 664 0.137694964887784 718 773758 YLR208W SEC13 SGTC_579 4491-1009 110 µM 1.08905432732567 0.201078990699315 no 665 0.138064964517821 911 1271041 SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM 1.08847400103395 0.201224116610745 no 666 0.138192954024833 767 4174840 SGTC_1179 1021-1431 9.29 µM 1.08700609890804 0.20159148451864 no 667 0.138517057168672 753 2840958 SGTC_1016 4226-1401 38 µM 1.08582261821514 0.201887963399283 no 668 0.138778738772802 727 2901613 SGTC_1237 0330-0133 46.1 µM 1.08571073813019 0.201916004463382 no 669 0.138803494192799 681 X1237 YHR072W ERG7 SGTC_3005 9076496 71.4286 µM 1.08553114898621 0.201961020661689 no 670 0.138843237710812 687 21368410 SGTC_2194 5927483 104.545 µM 1.07994344080084 0.203364646776876 no 671 0.140083683576969 754 760979 SGTC_2160 5660466 132.927 µM 1.07901771510622 0.203597748810977 no 672 0.140289915273719 700 2859134 SGTC_2544 sphondin 68.51 µM 1.0787604137714 0.203662566771147 no 673 0.140347273058024 678 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31 SGTC_2003 4023581 200 µM 1.07828781192413 0.203781654122542 no 674 0.140452667258516 694 16641307 SGTC_2314 7727897 200 µM 1.07356997339885 0.20497274027667 no 675 0.141507730676649 704 900724 SGTC_47 0149-0135 24.25 µM 1.07334410465145 0.205029867711242 no 676 0.141558376690447 684 5239155 SGTC_2366 9070441 60.58 µM 1.07326028350854 0.205051070426101 no 677 0.141577174830745 740 6837235 SGTC_2806 7952793 58.44 µM 1.07284053964173 0.205157265024057 no 678 0.141671334086543 743 2972490 SGTC_963 1269-2853 151 µM 1.07163307681783 0.205462933565977 no 679 0.141942435287605 677 3668223 SGTC_3293 9120939 62.045 µM 1.07140146597947 0.205521596618002 no 680 0.14199447699061 711 934087 SGTC_3171 9103192 49.47 µM 1.06946961346081 0.206011289003266 no 681 0.142429056988631 726 13018434 SGTC_62 0180-0423 3.232 µM 1.0675799758786 0.206490949426463 no 682 0.142855010070479 722 30102 YGL099W LSG1 SGTC_1859 st055998 20 µM 1.06747364072543 0.206517960898612 no 683 0.142879005194696 759 676301 SGTC_2414 st077232 92.9 µM 1.06738158145006 0.206541347673592 no 684 0.142899781086809 678 729801 SGTC_1037 k284-1091 78.7 µM 1.0672744961444 0.20656855364094 no 685 0.1429239506147 683 3334711 SGTC_560 2332-1943 155 µM 1.06664651335801 0.206728140929528 no 686 0.143065744127711 741 21177716 SGTC_2730 imipramine 71.33 µM 1.06560868932617 0.206992039833723 no 687 0.143300284788156 857 3696 A tricyclic antidepressant. SGTC_1940 st075990 51.1 µM 1.06472056852639 0.207218030258789 no 688 0.143501199680534 805 1084979 SGTC_978 1416-0512 87.4 µM 1.0646979685182 0.207223782939918 no 689 0.143506314841263 768 6814003 SGTC_1092 toremifene 6.32 µM 1.06236617193505 0.207817833641875 no 690 0.144034742322382 789 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_449 xestospongin c 11.1929 µM 1.06212056332181 0.207880463619144 no 691 0.144090477987364 760 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1 SGTC_1569 carminic acid 40.6 µM 1.0607640618222 0.208226571012682 no 692 0.144398569181082 755 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_3077 9117319 49.47 µM 1.06016001822518 0.208380800318405 no 693 0.144535903464034 694 17154678 SGTC_2138 5575593 77.673 µM 1.05955164201496 0.208536203946658 no 694 0.144674311725737 710 762213 SGTC_2878 9043973 25.97 µM 1.05660329041056 0.209290298372976 no 695 0.145346339091682 728 6465167 SGTC_640 3381-0960 37.1 µM 1.05502078765664 0.209695713230385 no 696 0.145707908795794 787 1745025 SGTC_289 k017-0060 526 µM 1.05223333738468 0.210410940633494 no 697 0.146346253920541 713 5512909 SGTC_2011 4012611 177 µM 1.05215197939393 0.21043183763658 no 698 0.146364913615115 756 2049887 SGTC_1779 st039427 55 µM 1.0517459641814 0.210536141866675 no 699 0.14645805827582 833 1124498 SGTC_1771 st048882 4.1505 µM 1.05157890736188 0.210579067128843 no 700 0.1464963946253 736 4580403 SGTC_1341 1486-1360 280 µM 1.0499720927144 0.210992200456266 no 701 0.146865471856444 756 3976547 SGTC_2498 4'-Methoxychalcone 54.63 µM 1.04962188434731 0.211082306691981 no 702 0.14694599566673 725 641818 YHR062C RPP1 SGTC_1472 k841-0093 193 µM 1.04807051769121 0.211481733962677 no 703 0.147303059237452 788 X1472 SGTC_541 4513-1321 94 µM 1.04743523586855 0.211645426346563 no 704 0.147449443798507 724 747515 SGTC_1218 1348-1416 30.7 µM 1.04635059355198 0.211925076306114 no 705 0.147699597274518 737 6787668 SGTC_1027 k015-0025 8.67 µM 1.04552456877741 0.212138192616961 no 706 0.147890295751121 746 3598955 SGTC_2715 st079500 56.4 µM 1.04521340172275 0.21221850691989 no 707 0.147962175403855 703 28246688 SGTC_1238 0333-0287 48.8 µM 1.04437099935333 0.212436025792493 no 708 0.148156887857164 736 7226 SGTC_2800 7887935 81.82 µM 1.04370938547416 0.212606954096126 no 709 0.148309933107032 716 2961002 SGTC_1804 st050076 49.1 µM 1.04174104248248 0.213115951263983 no 710 0.148765877515928 758 3895976 SGTC_3116 9124943 49.47 µM 1.03825459819559 0.214019259277871 no 711 0.149575769950345 703 41905195 YPL160W CDC60 SGTC_1441 4106-0040 13 µM 1.03762448984249 0.214182752440438 no 712 0.149722455915941 771 2904180 SGTC_2112 5488546 200 µM 1.03707637453551 0.214325030085858 no 713 0.14985013234778 756 600757 SGTC_870 0573-2213 57.6 µM 1.03311191153621 0.215355745506819 no 714 0.15077576482291 748 3916321 SGTC_1700 st030840 7.9285 µM 1.0317116983177 0.215720471206065 no 715 0.151103597782016 804 5499307 SGTC_1581 himbacine 57.9 µM 1.03084489999504 0.215946433027711 no 716 0.151306779418136 771 5281825 An alkaloid muscarinic receptor antagonist. SGTC_2365 9042475 200 µM 1.02999646936988 0.216167739405191 no 717 0.151505831477335 754 6464479 SGTC_191 3914-0123 66.505 µM 1.02984318604329 0.216207736144081 no 718 0.151541812154818 632 3144412 SGTC_1563 conessine 56.1 µM 1.02941331237232 0.21631992739744 no 719 0.151642748056501 880 441082 An anti-amoebic, histamine inhibitor. SGTC_696 1560-0013 611 µM 1.0256150095637 0.217312696771548 no 720 0.152536544843269 778 1650269 SGTC_2966 9084041 48.03 µM 1.02539369794594 0.217370622400846 no 721 0.152588730288059 709 17741380 SGTC_406 estrone 100 µM 1.02224354162022 0.218196103667181 no 722 0.153332823685701 790 5870 A steroid. SGTC_2737 bleomycin 30.5 nM 1.01950201491973 0.218915973686606 no 723 0.153982348538228 829 16211318 Bleomycin acts by induction of DNA strand breaks. SGTC_850 0388-0143 75.9 µM 1.01889519110346 0.21907549794543 no 724 0.154126363481493 739 67273 SGTC_438 sphingosine 6.67 µM 1.01784153714974 0.219352645427321 no 725 0.154376634339654 681 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes. SGTC_3083 9117465 49.47 µM 1.01661124361522 0.219676510069387 no 726 0.154669201652678 773 16420915 SGTC_2875 9039966 71.43 µM 1.01566222593 0.219926518632955 no 727 0.154895130919183 770 6463691 SGTC_1870 st057514 26.5 µM 1.01374165795803 0.220432970982705 no 728 0.155353020330918 764 5393161 SGTC_2610 ononetin 44.17 µM 1.01372710612314 0.220436810840535 no 729 0.155356493091599 782 259632 SGTC_3043 9092303 49.47 µM 1.01119654695593 0.221105143584719 no 730 0.15596118408352 719 25236084 SGTC_1661 st013063 9.66 µM 1.0108813284808 0.221188475418502 no 731 0.156036615780449 844 721395 SGTC_1389 3405-0187 19 µM 1.010604009105 0.221261803019395 no 732 0.156102998111262 721 799890 SGTC_2170 morpholine 200 µM 1.00776354420331 0.222013666704902 no 733 0.156783995547203 802 121171 Reacts with secondary amines. SGTC_2936 9038235 15.59 µM 1.00728512581145 0.222140446186809 no 734 0.156898887767092 750 4749415 SGTC_1335 1486-0900 202 µM 1.0071477465886 0.222176858915899 no 735 0.156931889634367 808 X1335 SGTC_1475 4092-1048 11.7 µM 1.00518278105082 0.22269805092789 no 736 0.157404422445396 833 2881759 SGTC_86 0417-1630 471.922 µM 1.00476693762292 0.222808439477557 no 737 0.157504543805086 892 3634867 SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM 1.00438491186379 0.222909878363307 no 738 0.157596559863626 763 115019 SGTC_2534 helenine 20.12 µM 1.00414954273797 0.222972388767672 no 739 0.157653269274009 733 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58 SGTC_3012 9080433 71.4286 µM 1.00269871329895 0.223357927045487 no 740 0.158003125461034 832 17688859 SGTC_408 cantharidin 100 µM 1.00244582724136 0.223425166892336 no 741 0.15806415908411 802 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_2326 6164455 177.58 µM 0.999600326879219 0.224182550083379 no 742 0.158751982452096 734 2888790 SGTC_2386 9075165 157.42 µM 0.999291925456558 0.224264724377713 no 743 0.15882664790012 795 16452277 SGTC_3172 9105863 49.47 µM 0.999124945479659 0.224309223726122 no 744 0.158867084148687 763 2348785 SGTC_2353 9059630 146.67 µM 0.999095055079412 0.224317189900743 no 745 0.158874323187503 803 4779114 SGTC_1957 st077035 62.4 µM 0.99635466438461 0.225048221158536 no 746 0.159538926138434 829 705593 SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM 0.996021985746769 0.225137058873556 no 747 0.159619731462054 769 6708514 SGTC_1768 st044301 37.178 µM 0.995757151861002 0.225207793687674 no 748 0.15968407691263 813 3931349 SGTC_2528 xanthyletin 44.79 µM 0.995280474658549 0.22533514171302 no 749 0.159799935705914 809 65188 An natural product with antifungal activity of unknown mechanism. SGTC_1250 0485-0349 40.2 µM 0.994606106573403 0.225515374027466 no 750 0.159963938173353 764 6842794 YDL195W SEC31 SGTC_520 3584-0023 682 µM 0.992517820613656 0.226074008737665 no 751 0.16047249535981 748 1340790 SGTC_1611 st001856 99.4 µM 0.992284001626678 0.226136606009585 no 752 0.160529502637511 784 647478 SGTC_660 4031-1742 102 µM 0.989419636348096 0.226904239237884 no 753 0.161228935533652 830 6738706 SGTC_1659 st012954 42.1 µM 0.987837854963494 0.227328776578283 no 754 0.161616032420611 794 24207262 SGTC_3053 9095903 49.47 µM 0.985709254303307 0.227900781504803 no 755 0.16213790346373 842 17174018 SGTC_3290 9121031 71.43 µM 0.984478276112494 0.228231943428128 no 756 0.162440203799102 755 17014854 SGTC_2728 chlorpromazine 9.18 µM 0.984074145247103 0.228340723037227 no 757 0.162539529105537 717 2726 A thorazine and dopamine antagonist. SGTC_1275 0867-0008 21.1 µM 0.983692383207328 0.228443508403637 no 758 0.162633393000752 818 3422836 SGTC_2521 angolensin 13.4 µM 0.983213818471021 0.228572393577163 no 759 0.162751107589779 779 821428 A flavenoid. SGTC_3006 9075424 71.4286 µM 0.982985663832216 0.228633853661923 no 760 0.16280724725208 779 7465181 SGTC_2367 9070478 135.38 µM 0.98262202237494 0.228731830241146 no 761 0.162896750789104 804 572802 SGTC_2227 7312221 64.1025 µM 0.982603960031376 0.228736697425667 no 762 0.162901197330709 849 887188 YOR168W | YOR169C GLN4 | YOR169C SGTC_583 1488-1091 88.9 µM 0.982134593237351 0.228863196127827 no 763 0.163016772520062 974 4303273 SGTC_2253 7938677 135.83 µM 0.980922570680406 0.229190028978127 no 764 0.16331546306293 815 2301972 SGTC_1221 2958-7315 257 µM 0.980693417472086 0.229251851623122 no 765 0.163371975464897 787 4562705 SGTC_744 1594-0068 283 µM 0.98055446742741 0.229289343145841 no 766 0.163406248684727 865 668392 SGTC_149 3970-0822 46.1 µM 0.979439699920031 0.229590254276197 no 767 0.163681384671096 935 3114250 YBL034C STU1 SGTC_2943 9068529 45.32 µM 0.97803384483938 0.229970054414779 no 768 0.164028792581378 915 3270634 SGTC_2826 7992541 19.48 µM 0.978023552940766 0.22997283612855 no 769 0.164031337626659 788 2985066 SGTC_796 1234-0020 70.7 µM 0.974981917431377 0.230795759843399 no 770 0.164784614835453 779 46495034 SGTC_1339 1486-1321 22.7 µM 0.974419767981975 0.230948030950384 no 771 0.164924079091377 835 3469382 SGTC_1126 isoteolin 1.0172 µM 0.974089062494976 0.231037636334222 no 772 0.165006159868207 794 133323 SGTC_2054 5233173 129 µM 0.973924337954055 0.231082276052352 no 773 0.165047054204256 858 6889 SGTC_2593 nobiletin 86.24 µM 0.97243410128929 0.231486343155452 no 774 0.165417316916541 760 72344 An anti-infammatory. SGTC_334 1502-1024 68.5 µM 0.971402240435237 0.231766355555947 no 775 0.165674006653018 855 3296216 SGTC_2601 securinine 100 µM 0.970746039681181 0.231944524529211 no 776 0.1658373796224 793 442872 A GABA receptor antagonist. SGTC_3267 9137951 49.47 µM 0.969831286414625 0.232193021856872 no 777 0.166065297594974 818 16643986 SGTC_1655 st012546 55.1 µM 0.966905188545671 0.232988905199577 no 778 0.166795716310018 803 720985 YLR208W SEC13 SGTC_1373 2887-0003 58.5 µM 0.963732782391182 0.233853492187296 no 779 0.167589957105848 797 776948 SGTC_2617 dihydrotanshinone i 20.83 µM 0.963217189626875 0.233994176257038 no 780 0.167719270216669 866 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12 SGTC_2382 9035899 200 µM 0.962378450486849 0.234223133820316 no 781 0.167929767213018 848 6462679 SGTC_2022 5136654 200 µM 0.961001011940609 0.234599413565308 no 782 0.16827582951376 805 1713771 SGTC_2156 5649887 115 µM 0.960153016229627 0.23483122970906 no 783 0.168489104626724 925 54680440 YKL052C | YBR257W ASK1 | POP4 SGTC_2912 7964298 10.93 µM 0.959452551275372 0.235022810895653 no 784 0.168665406040452 885 2975850 SGTC_2623 humulene 100 µM 0.957884072906404 0.235452111716832 no 785 0.169060609305984 712 6187145 An anti-inflammatory. SGTC_2694 st077685 81.9 µM 0.957259608740233 0.235623151226483 no 786 0.169218118447533 805 2838096 SGTC_2589 lobaric acid 100 µM 0.957178977325348 0.235645241007689 no 787 0.169238463045403 810 73157 A novel microtubule depolymerizer. SGTC_1259 0671-0132 43 µM 0.956760837964349 0.235759812779657 no 788 0.169343991490737 809 X1259 SGTC_1592 4',5'-dihydroxyflavone 8.85 µM 0.953597896323704 0.236627464979081 no 789 0.170143610512194 867 688669 SGTC_3321 9137793 26.8275 µM 0.953203436894797 0.236735795417408 no 790 0.170243502686155 854 4904192 SGTC_1438 4092-1045 4 µM 0.951020249304455 0.237335857458026 no 791 0.170797048352017 861 1351342 SGTC_1401 3807-4679 7.6 µM 0.949873579328093 0.237651360728965 no 792 0.171088246553795 827 3291456 SGTC_2131 toluylene red 5.2905 µM 0.949221560342096 0.237830864640423 no 793 0.171253969078606 828 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain. SGTC_82 0054-0107 293.755 µM 0.948787006241176 0.237950540720529 no 794 0.171364475911055 866 3104697 SGTC_128 0906-2981 13.371 µM 0.948229159807562 0.238104219858539 no 795 0.171506402705081 791 6740226 SGTC_694 1315-0438 43.2 µM 0.944316200765465 0.239183714465253 no 796 0.172504044772774 793 6793154 SGTC_770 0389-1121 67.2 µM 0.944279060621032 0.239193973366192 no 797 0.172513531663328 911 6753108 SGTC_2419 paclitaxel 166.5 µM 0.944014874034465 0.23926695428031 no 798 0.17258102374884 884 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_1403 3909-7815 62.9 µM 0.943235276355052 0.239482387180407 no 799 0.172780286699729 822 6615483 SGTC_66 0109-0187 42.4 µM 0.942351362414982 0.239726774752117 no 800 0.173006389902998 781 759417 SGTC_1432 4049-0298 68.4 µM 0.941174477156293 0.240052375154337 no 801 0.173307726944643 868 741646 SGTC_3277 9138724 49.47 µM 0.940608238889967 0.24020911810104 no 802 0.173452829119191 764 15943418 SGTC_1981 st071826 47 µM 0.940497319808684 0.240239828639672 no 803 0.173481261897327 813 11838600 SGTC_1455 4262-0120 131 µM 0.939858018361058 0.240416875876055 no 804 0.173645196983305 893 1529587 SGTC_1984 st072354 53.1 µM 0.937503314551998 0.241069596720831 no 805 0.174249859797033 854 5762938 SGTC_2706 st078239 82.5 µM 0.937455960436787 0.241082733096307 no 806 0.174262033536849 865 15434492 SGTC_3296 9122258 64.045 µM 0.935371876086232 0.241661258546326 no 807 0.174798342709124 862 4730474 SGTC_401 neomycin 50 µM 0.933863535136755 0.242080431801016 no 808 0.175187145380667 841 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis. SGTC_2906 7926292 26.41 µM 0.930924680652316 0.242898280999731 no 809 0.175946263345591 870 2966319 SGTC_2844 9010103 25.97 µM 0.930911246623937 0.2429020229638 no 810 0.175949738184979 830 2480525 SGTC_2666 tannic acid 100 µM 0.930010649950177 0.243152949618205 no 811 0.176182785193987 905 16134267 A thiamine antagonist. SGTC_1076 itraconazole 331 nM 0.928930315462468 0.243454140113541 no 812 0.176462600497184 914 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1 SGTC_2877 9040724 71.43 µM 0.928604448818007 0.243545029246769 no 813 0.176547057728902 892 6463895 SGTC_1358 1509-0022 2.48 µM 0.928256380790038 0.243642130920627 no 814 0.1766372972871 903 3258434 SGTC_2675 theaflavin digallate 100 µM 0.927875378549923 0.24374844432021 no 815 0.176736108746329 891 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative. SGTC_271 rotenone 740 µM 0.927015396399803 0.243988502457876 no 816 0.17695927022354 881 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria. SGTC_2497 7-hydroxyflavone 100 µM 0.924460334924024 0.244702482175377 no 817 0.17762334694904 810 5281894 SGTC_260 nsc-65238 3.989 µM 0.923718644217057 0.244909948766028 no 818 0.177816411209719 865 3246252 SGTC_835 0312-0010 67.2 µM 0.923236047880897 0.245044991991158 no 819 0.17794210350539 847 1626196 SGTC_2487 5918373 44.05 µM 0.919841761969679 0.245995933580436 no 820 0.178827728053518 956 2876279 SGTC_531 3788-1495 174 µM 0.918621840612493 0.24633818924321 no 821 0.179146702048572 833 2896655 SGTC_3210 9128157 49.47 µM 0.91789219190604 0.246543018134811 no 822 0.179337654926205 785 17590849 SGTC_469 w7 172 µM 0.916377003420273 0.24696865710798 no 823 0.179734596317074 879 45115570 A P450 inhibitor. SGTC_1857 st056007 79.3 µM 0.916302029424845 0.246989728622976 no 824 0.179754251945631 886 619834 SGTC_2284 7945075 39.21 µM 0.91561327016581 0.247183350091641 no 825 0.179934884351454 969 1245402 SGTC_3131 9127911 49.47 µM 0.915057858257114 0.247339544544797 no 826 0.180080628384313 836 45595681 SGTC_906 1165-0455 526 µM 0.914465517235504 0.247506182425129 no 827 0.180236144522809 866 3252859 SGTC_1925 st057770 10.1 µM 0.911670044864119 0.24829341598467 no 828 0.180971218691143 806 5989122 SGTC_3192 9110362 49.47 µM 0.911023038673499 0.248475809591668 no 829 0.181141617405053 925 16649480 SGTC_678 1218-2179 85.9 µM 0.909765679890551 0.248830468108558 no 830 0.181473048890093 888 6820081 YOR116C RPO31 SGTC_2155 5570423 76 µM 0.907244769047579 0.249542343064035 no 831 0.182138686977102 837 797402 SGTC_1342 1486-1464 234 µM 0.905917654835139 0.249917538488263 no 832 0.18248971947493 902 3253938 SGTC_2061 5245884 80.95 µM 0.904533492418366 0.250309181071521 no 833 0.182856291588675 903 573863 SGTC_648 0375-0473 33.3 µM 0.899464775645944 0.251746124835324 no 834 0.18420257495233 929 1713139 SGTC_1353 1498-1206 8.11 µM 0.896387679966021 0.252620578850592 no 835 0.18502287247347 942 6756808 SGTC_597 k018-0003 82.8 µM 0.896370167103243 0.252625560259056 no 836 0.185027547568578 1003 6786234 SGTC_171 k064-0041 9.68 µM 0.895531643694188 0.252864132774923 no 837 0.185251479011633 832 53325 SGTC_3079 9117512 49.47 µM 0.895210230361752 0.252955611131424 no 838 0.185337358485218 985 7185044 SGTC_34 0469-0683 81.75 µM 0.895024171091592 0.253008573943549 no 839 0.185387083560799 924 3690923 SGTC_3285 9112818 20.8695 µM 0.893695585711759 0.253386932725062 no 840 0.185742393930019 956 17017947 YPR165W RHO1 SGTC_303 1348-1668 34.2 µM 0.893029847472155 0.253576635569497 no 841 0.185920594471033 906 5380509 SGTC_339 3091-4833 71.4 µM 0.892974132726727 0.253592514930085 no 842 0.185935512642492 905 3240077 SGTC_453 enantio-paf c16 10 µM 0.891647867221312 0.253970670426299 no 843 0.186290852391958 978 13871343 A lipid and platelet activating factor SGTC_306 1672-3436 11.6 µM 0.889957052473776 0.254453197870584 no 844 0.186744473697792 938 6797378 SGTC_667 1498-1044 59 µM 0.889392032375936 0.254614551243516 no 845 0.186896212763122 950 6739982 SGTC_179 1273-0063 6.77 µM 0.887311627476554 0.255209116232586 no 846 0.187455573594218 885 3108139 SGTC_1721 st082152 9.2685 µM 0.886956856783879 0.255310579591557 no 847 0.187551064358006 885 5296051 SGTC_2572 astragaloside iv 100 µM 0.885008851347351 0.255868078872712 no 848 0.188075928734625 897 45006101 An anti-inflammatory agent. SGTC_656 4090-1979 187 µM 0.882074620128556 0.256709023601361 no 849 0.188868227976406 988 22330961 SGTC_1920 st075728 45.7 µM 0.881421018316393 0.256896540332039 no 850 0.189044992800314 915 3400306 SGTC_785 1270-0111 65.3 µM 0.881401151744021 0.256902241118077 no 851 0.189050367255754 973 6741994 SGTC_3242 9133940 49.47 µM 0.881005206889918 0.257015872678945 no 852 0.189157500880846 954 17248444 SGTC_269 exalamide 29 µM 0.880003955085023 0.257303336889899 no 853 0.189428583488538 914 3316 A derivative of salicylamide. SGTC_417 st075190 100 µM 0.877730022566087 0.257956814036341 no 854 0.190045123871815 968 222757 SGTC_776 4476-4378 112 µM 0.877488454315327 0.25802628588264 no 855 0.19011069362588 899 2892008 SGTC_3135 9127742 49.47 µM 0.876662848511701 0.258263792471014 no 856 0.190334895761337 877 3643468 SGTC_155 k072-0202 43.6 µM 0.874864909536166 0.258781407311296 no 857 0.190823707060526 926 5857737 SGTC_2430 5571206 200 µM 0.87392054929105 0.259053497329899 no 858 0.19108076148847 1040 1731771 SGTC_2525 harmine 47.85 µM 0.867568355167861 0.260887534587954 no 859 0.192815338166719 910 5280953 A monoamine oxidase inhibitor SGTC_1195 1502-0147 41.1 µM 0.866667432037014 0.261148193342548 no 860 0.19306212740259 997 817940 SGTC_1905 st060207 84.5 µM 0.864326043388706 0.261826238844121 no 861 0.193704403699271 941 1948547 SGTC_574 1315-0397 40 µM 0.864172559211502 0.261870718023916 no 862 0.193746552048554 1053 6794277 SGTC_979 1426-2828 121 µM 0.862720099753959 0.26229182748281 no 863 0.194145689257012 991 747872 SGTC_2830 7992007 71.43 µM 0.862560952098241 0.26233799000737 no 864 0.194189453606689 910 1952075 SGTC_516 3992-2719 87.3 µM 0.861675576177385 0.262594878953258 no 865 0.19443303467874 984 5350887 YDR037W KRS1 SGTC_1986 st071812 45 µM 0.860949798437749 0.262805556980297 no 866 0.194632846396646 919 11838594 SGTC_136 0097-0015 404.482 µM 0.860768650436108 0.262858153916062 no 867 0.194682737193305 1054 4861337 SGTC_460 trequinsin 123 µM 0.860609935285701 0.262904241821269 no 868 0.194726456050587 1008 5537 A vasodilator. SGTC_1939 st074455 53.6 µM 0.860185062437928 0.263027637263997 no 869 0.194843518726072 966 1644229 SGTC_3256 9138902 49.47 µM 0.859183830092247 0.263318541305306 no 870 0.195119551512003 1002 17228773 SGTC_1292 0kpi-0043 232 µM 0.859091607871769 0.26334534436256 no 871 0.1951449884854 919 3333905 SGTC_3102 9121669 49.47 µM 0.85822903460181 0.263596106265432 no 872 0.195383003267402 962 41905072 SGTC_1068 loratadine 26.9 µM 0.855294138420369 0.264450232448926 no 873 0.196194165863418 922 3957 A H1 histamine antagonist. SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM 0.855151929921194 0.264491654331001 no 874 0.196233522024432 936 5355888 SGTC_2427 5545055 42.75 µM 0.854843873799382 0.264581394918621 no 875 0.196318792881139 1010 5372858 SGTC_2062 5245942 200 µM 0.853845529521458 0.264872331454091 no 876 0.196595291881502 1052 1376160 SGTC_2725 haloperidol 53.21 µM 0.852601666181331 0.26523504429209 no 877 0.196940119145422 977 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_994 3910-0338 138 µM 0.85105119853203 0.265687516333981 no 878 0.197370456384193 998 3479481 SGTC_594 1487-1584 10.8 µM 0.850919128636869 0.265726076292983 no 879 0.197407139070592 992 5013332 SGTC_2417 cerulenin 830 nM 0.850855822033745 0.265744560693739 no 880 0.1974247240722 968 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1 SGTC_544 k015-0020 52.4 µM 0.850603369155689 0.265818278920553 no 881 0.197494858630156 944 3008304 SGTC_1853 st056710 91.2 µM 0.850100372110714 0.265965188907467 no 882 0.197634642383182 1036 269167 SGTC_1512 0259-0544 12.2 µM 0.848036910486084 0.266568292847749 no 883 0.198208707532402 993 18476 SGTC_879 0831-1030 162 µM 0.844776622210987 0.267522610130195 no 884 0.199117784744641 979 1549252 SGTC_402 epigallocatechin gallate 10 µM 0.841335740426493 0.268531653888909 no 885 0.200079936811557 984 65064 An antioxidant. SGTC_2475 5812728 15.03 µM 0.841306010923145 0.268540380439608 no 886 0.200088262044281 1064 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2 SGTC_883 0850-0245 24.6 µM 0.839196170060719 0.269160049345628 no 887 0.200679618081411 1005 6823229 YPR165W RHO1 SGTC_2291 7917025 104.35 µM 0.838979147140224 0.269223830534911 no 888 0.200740505733023 947 2964612 SGTC_2852 9023854 51.95 µM 0.838456749673189 0.269377389785904 no 889 0.200887114310066 982 19798528 SGTC_1601 4'-hydroxyflavanone 55.5 µM 0.837214159852611 0.269742826658105 no 890 0.201236099808144 1008 165506 SGTC_760 0568-0725 82.9 µM 0.837100296093694 0.269776325597309 no 891 0.201268096995088 1026 3916171 SGTC_511 blebbistatin 171 µM 0.835390450582172 0.270279615859865 no 892 0.20174895237971 989 3476986 A myosin inhibitor. SGTC_1808 st050063 61.5 µM 0.834954330394108 0.270408062231529 no 893 0.201871711353415 978 4011993 SGTC_765 1319-0117 244 µM 0.834776121541152 0.270460557185356 no 894 0.201921886393186 1003 3487746 YGL099W LSG1 SGTC_494 Boc-Gly-Val-Val-CHO 140 µM 0.833898195881421 0.270719241924767 no 895 0.202169176984922 1034 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA. SGTC_1985 st071382 65.5 µM 0.833253136401345 0.270909390298173 no 896 0.202350990186605 1065 6123237 SGTC_2231 micatex 6.853 µM 0.832563374095634 0.271112789720831 no 897 0.202545511246377 1013 20737 An antifungal of unknown mechanism. SGTC_1072 oxiconazole 14.9 nM 0.832153670983872 0.271233640390531 no 898 0.202661105227604 1004 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_144 4161-2749 112.381 µM 0.831517623370437 0.271421309389133 no 899 0.202840638331559 899 797501 YMR168C CEP3 SGTC_2091 4-phenylthiadiazole 200 µM 0.831394699877612 0.271457586032607 no 900 0.20287534611417 1006 270010 SGTC_3355 9151058 44.0485 µM 0.830843320090099 0.271620336533234 no 901 0.203031073336165 1029 17015728 SGTC_1057 3448-5381 134 µM 0.828854634749891 0.272207739124873 no 902 0.203593334147398 1025 5497911 SGTC_2031 5180455 200 µM 0.828441273759249 0.272329913722229 no 903 0.203710320119267 1000 29949 SGTC_2704 st078022 71.1 µM 0.82479479409313 0.273408860284161 no 904 0.204744051371474 1017 54697681 SGTC_3087 9117406 49.47 µM 0.824655762391497 0.273450039831424 no 905 0.204783526765852 986 42546093 SGTC_2825 7998094 58.44 µM 0.824399132209934 0.273526058722731 no 906 0.20485640388887 956 2987815 SGTC_993 3909-8757 62.7 µM 0.824330631342479 0.273546351791184 no 907 0.204875859181474 917 4288324 YLR208W SEC13 SGTC_1001 4048-4355 44.4 µM 0.822671298026935 0.274038149205758 no 908 0.20534747074776 972 21824233 SGTC_2508 celastrol 40.54 µM 0.822336842848168 0.274137328761585 no 909 0.205442606787851 960 122724 Celastrol is a natural product and antioxidant. SGTC_51 1013-0126 23.419 µM 0.821779030737525 0.274302782165865 no 910 0.20560133510178 973 1627850 SGTC_1182 1222-0449 220 µM 0.821457295589509 0.274398234877773 no 911 0.205692919593023 974 658318 SGTC_221 trifluoperazine 10.304 µM 0.821454399139917 0.27439909427385 no 912 0.205693744200592 1105 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1 SGTC_3197 9113331 49.47 µM 0.821443860151274 0.274402221273884 no 913 0.205696744624901 1001 16610459 YLR208W | YDL195W SEC13 | SEC31 SGTC_3337 9144342 33.5465 µM 0.820532174318139 0.274672792115142 no 914 0.205956397655686 1014 17682949 SGTC_1546 5-methoxyflavanone 78.7 µM 0.819952482886252 0.274844901796078 no 915 0.206121597954747 1049 147795 SGTC_2134 5324836 1.464 µM 0.819535476029458 0.274968743488241 no 916 0.20624048502265 947 699272 SGTC_889 0919-1524 82.7 µM 0.818790122301706 0.275190165308883 no 917 0.206453083758864 964 3905452 SGTC_2937 9044753 11.33 µM 0.817736893578438 0.275503196978379 no 918 0.206753719559335 1069 6465530 YGL099W LSG1 SGTC_2575 plumbagin 510 nM 0.817198385800393 0.275663315312292 no 919 0.206907532429111 964 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_1381 2324-0066 62.1 µM 0.817161590327963 0.275674257640422 no 920 0.206918044715508 958 10885928 SGTC_196 k015-0023 18.111 µM 0.811968695230439 0.277220671459228 no 921 0.20840479729817 1025 5211998 SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM 0.811198587127711 0.27745036595839 no 922 0.208625818438201 975 5379071 SGTC_1422 4031-0024 15.5 µM 0.810987972152145 0.277513200739825 no 923 0.208686289021374 1009 782427 SGTC_1531 st059297 52.4 µM 0.80816965803655 0.278354683893256 no 924 0.209496461026913 1038 7566702 SGTC_666 0272-0154 136 µM 0.807449303837215 0.278569964315323 no 925 0.209703835543023 1028 6870312 SGTC_1460 k062-0059 9.15 µM 0.806533340762182 0.278843820208713 no 926 0.209967695899439 1037 1373085 SGTC_952 1185-0122 232 µM 0.806138701753255 0.278961850288299 no 927 0.210081439184144 1043 678600 SGTC_1419 3993-2473 62.6 µM 0.803500853163562 0.279751411225245 no 928 0.210842651917533 1043 704026 SGTC_2654 protoveratrine a 100 µM 0.802608659648624 0.280018707794435 no 929 0.211100480779258 1049 5702278 A heart drug and vasodilator. SGTC_2858 9025781 8.96 µM 0.800230683562939 0.280731741306802 no 930 0.211788577670429 1107 4894980 YPL153C RAD53 SGTC_3050 9093513 49.47 µM 0.800058767088466 0.280783324290447 no 931 0.211838374654479 1096 25236664 SGTC_385 1494-0393 12.4 µM 0.799039949122823 0.281089111362525 no 932 0.21213362400055 1035 3090647 SGTC_1945 st075991 56.6 µM 0.798130358292094 0.281362250960705 no 933 0.212397422932688 990 1084980 SGTC_1111 tnp00062 510.699 nM 0.797151163198457 0.281656435019001 no 934 0.212681622576348 1085 676306 SGTC_1513 0337-0559 19 µM 0.797092157830557 0.281674167008258 no 935 0.212698755267762 963 775073 SGTC_1551 6-bromo-3'-methylflavone 63.5 µM 0.797079731601833 0.281677901343124 no 936 0.212702363427677 1068 688751 SGTC_2259 7964009 200 µM 0.795760776852243 0.28207440978435 no 937 0.213085546808287 982 313134 SGTC_3016 9080866 49.47 µM 0.795617528339738 0.282117489789861 no 938 0.213127187665272 1081 17066299 SGTC_828 2074-0507 139 µM 0.795286094595451 0.282217176037963 no 939 0.213223550210985 1080 X828 SGTC_2846 9008642 19.48 µM 0.794973063489996 0.282311342837773 no 940 0.213314585616789 996 2992898 SGTC_750 4073-0104 132 µM 0.794752079727212 0.282377828827742 no 941 0.213378865545988 888 22330957 SGTC_1185 1319-0113 81.3 µM 0.793227390263613 0.282836757666161 no 942 0.21382267602367 1032 4672763 SGTC_3255 9139072 49.47 µM 0.792867604099376 0.282945104886057 no 943 0.213927481829044 1091 17646060 SGTC_1766 st045414 44.774 µM 0.792452704915013 0.283070073762209 no 944 0.214048379194385 1122 253960 SGTC_1674 st016616 23.6 µM 0.792380540635644 0.283091812563296 no 945 0.214069411183977 1064 625830 SGTC_3263 9137018 49.47 µM 0.791885676800107 0.283240907155992 no 946 0.214213669662036 1022 43844957 SGTC_1434 4073-0095 163 µM 0.791816584400863 0.28326172659164 no 947 0.214233815386661 1090 24133745 SGTC_1421 4029-0249 71.4 µM 0.789829508403074 0.283860800993178 no 948 0.214813671706902 1131 2894095 SGTC_2018 5133068 143 µM 0.788777742030091 0.284178138471631 no 949 0.215120960387289 999 785362 SGTC_2790 5423970 71.43 µM 0.788522735016302 0.284255104374171 no 950 0.215195502774262 1067 1376240 YKL165C | YIL048W MCD4 | NEO1 SGTC_2403 6032726 181.2 µM 0.787520552941769 0.284557678230195 no 951 0.215488600876086 1034 2881040 SGTC_2853 9015042 58.44 µM 0.787114032448054 0.284680456722009 no 952 0.215607557812323 1041 6457456 SGTC_866 0495-0101 262 µM 0.786087122189052 0.284990719697427 no 953 0.21590822412088 989 635694 SGTC_1303 1160-0052 261 µM 0.785764905346469 0.285088105107004 no 954 0.216002615180254 1102 3562476 SGTC_2285 7945142 200 µM 0.78480593380105 0.285378034302801 no 955 0.216283680264868 1037 2970608 SGTC_1819 st053448 58.6 µM 0.780717593337197 0.286615649350412 no 956 0.217484305368647 1050 2857616 SGTC_898 1000-0849 28.3 µM 0.780655585740227 0.286634439758901 no 957 0.21750254474149 1079 6751807 SGTC_1073 triclabendazole 3.09 µM 0.779823138243834 0.286886756181806 no 958 0.217747492480339 1093 50248 An antihelmetic and likely tubulin inhibitor. SGTC_386 1509-0011 3.07 µM 0.779150460744538 0.287090722866002 no 959 0.217945544087751 1129 3107280 SGTC_2123 5259487 200 µM 0.778895811921944 0.287167954415833 no 960 0.218020545607148 1078 2173474 SGTC_3221 9128209 49.47 µM 0.777350229706514 0.287636919512723 no 961 0.218476083847923 1035 16460723 SGTC_831 k061-1017 217 µM 0.776449010140015 0.287910537162522 no 962 0.218741958207183 1148 1240153 SGTC_384 k007-0144 5.16 µM 0.775151403498064 0.288304716917314 no 963 0.219125100047319 1070 6824886 SGTC_614 0462-0418 107 µM 0.774300046851988 0.288563475503243 no 964 0.219376687992602 981 5188303 SGTC_278 4092-0821 23.9 µM 0.772105066380146 0.289231114998996 no 965 0.220026100888795 1076 877900 SGTC_1287 0971-0001 34.6 µM 0.770812713600221 0.289624544714939 no 966 0.220408975184514 1087 4665869 SGTC_2801 7907800 81.82 µM 0.77031375349572 0.289776509853393 no 967 0.220556899942986 1098 6620925 SGTC_3167 9103034 49.47 µM 0.768087653800704 0.290454954390592 no 968 0.221217555650914 1089 5127859 SGTC_2864 9034755 47.6 µM 0.76806307832849 0.290462448362284 no 969 0.221224855403563 1115 4930451 SGTC_995 3931-2021 34.6 µM 0.767469571917892 0.290643457928084 no 970 0.221401188872306 1041 730143 SGTC_2113 5491891 107.031 µM 0.767057181374105 0.290769261234273 no 971 0.221523759294698 1136 789979 SGTC_98 0074-0023 107.663 µM 0.76359052532787 0.291827799924092 no 972 0.222555648614429 1112 3563821 SGTC_2464 5717415 7.67 µM 0.763346257334718 0.291902454478885 no 973 0.22262846095314 1061 5285744 SGTC_2431 5490079 200 µM 0.763277739992438 0.291923396730829 no 974 0.22264888730343 1150 5722345 SGTC_225 nsc-122657 1.016 µM 0.762610355937157 0.292127418540304 no 975 0.222847903323453 995 275685 SGTC_2411 st077133 39.94 µM 0.762533353653599 0.292150962696484 no 976 0.22287087216605 1112 1403142 YNL221C POP1 SGTC_2697 mebhydrolin 72.4 µM 0.760239556938597 0.292852716701889 no 977 0.223555701996918 1096 22530 H1 Histamine receptor antagonist. YIL048W NEO1 SGTC_570 0987-0065 62.6 µM 0.758705326834154 0.293322528540124 no 978 0.224014424841787 1000 3104428 SGTC_657 3534-0529 86.7 µM 0.758359577094677 0.293428452209636 no 979 0.22411787510426 1111 1049549 SGTC_3198 9112019 49.47 µM 0.757463910643634 0.293702930388272 no 980 0.224385989684145 1103 45595555 SGTC_3100 9120536 49.47 µM 0.757083140418036 0.293819653917482 no 981 0.224500027028723 1000 16421196 SGTC_1470 k295-0292 231 µM 0.756684185488916 0.293941974909106 no 982 0.224619545804111 1114 5045612 SGTC_1605 st000082 49.1 µM 0.75546799749426 0.294315007679866 no 983 0.224984113611912 1099 1114022 SGTC_2132 5317594 122.667 µM 0.755064062313491 0.29443895221774 no 984 0.225105272462254 1051 794577 SGTC_2228 7354201 200 µM 0.754954100139846 0.294472697473525 no 985 0.225138261606362 1138 753451 SGTC_3204 9114183 49.47 µM 0.754953102816156 0.294473003540967 no 986 0.225138560820464 1096 17027248 SGTC_3099 9120367 49.47 µM 0.754944344152444 0.294475691482823 no 987 0.225141188578509 1120 24824940 SGTC_1842 st055362 61.2 µM 0.754126869305596 0.294726615759929 no 988 0.22538652234553 1119 676032 SGTC_2833 9001315 45.46 µM 0.753380129542913 0.294955914004291 no 989 0.225610759907785 1074 2989378 SGTC_292 k038-0015 474 µM 0.752608050342138 0.295193079516626 no 990 0.225842739300389 1123 46368540 SGTC_1386 3228-0095 33.8 µM 0.75255383396766 0.295209736876236 no 991 0.225859034253005 1087 870181 SGTC_2673 kobusone 100 µM 0.751512136492664 0.295529870478359 no 992 0.226172249765139 1160 6710676 An epoxy ketone and protein crosslinker. SGTC_794 k038-0031 316 µM 0.750126384034513 0.295955986023573 no 993 0.226589295217061 1133 6624242 SGTC_1355 1499-0035 1.68 µM 0.749102758104167 0.296270929566936 no 994 0.226897636392246 1111 1548538 SGTC_1391 3442-0225 151 µM 0.748818938787531 0.29635828072787 no 995 0.226983171603247 1067 5227075 SGTC_2109 5483026 200 µM 0.748556099561127 0.296439185368814 no 996 0.227062400215837 1116 759335 SGTC_753 1322-0200 289 µM 0.747702422473477 0.296702025840687 no 997 0.227319834830084 1136 5403907 SGTC_1241 0364-0022 50.8 µM 0.747594900183991 0.296735138674883 no 998 0.227352270877416 1100 4563895 SGTC_1452 4194-0072 190 µM 0.746543632171223 0.297058978915944 no 999 0.227669542273915 1157 1343545 SGTC_23 0213-0011 39.996 µM 0.74577482790141 0.297295909243416 no 1000 0.227901724162984 1112 627608 SGTC_2907 7721985 69.9 µM 0.745230133541439 0.297463825554754 no 1001 0.228066304581463 1108 3267881 SGTC_2217 6934799 96.0675 µM 0.744501409521459 0.297688541536354 no 1002 0.228286594399708 1090 675606 SGTC_1136 pergolide 1.05886 µM 0.743549428469035 0.297982219723387 no 1003 0.228574553849117 1074 47811 A dopamine receptor agonist. SGTC_8 0354-0001 70 µM 0.742395852996751 0.298338264955881 no 1004 0.228923765704647 1171 4993152 SGTC_3244 9134489 49.47 µM 0.741952648881783 0.298475109139431 no 1005 0.229058012595508 1113 16584271 SGTC_2480 5767542 37.17 µM 0.740921782847284 0.298793510866956 no 1006 0.229370433525289 1141 2867358 SGTC_746 1095-0025 46.6 µM 0.740684390207176 0.298866855763314 no 1007 0.229442413096016 1138 6749286 SGTC_2015 5119600 184 µM 0.738513525835805 0.299537945699412 no 1008 0.230101225458667 1120 2828786 SGTC_3054 9094397 49.47 µM 0.738204365428813 0.299633573502878 no 1009 0.23019513525963 1143 2598354 SGTC_844 0330-0132 15.3 µM 0.737704675236962 0.299788164173728 no 1010 0.23034696523552 1150 2828079 SGTC_740 k014-0057 261 µM 0.73741449995658 0.299877953153573 no 1011 0.230435160171668 1133 4012779 SGTC_529 4076-0302 30.3 µM 0.736276225268075 0.300230287135635 no 1012 0.230781305898353 1076 5816522 SGTC_2925 9010536 32.5 µM 0.735682497625025 0.300414139880669 no 1013 0.230961971776932 1121 2994177 SGTC_2768 sulfasalazine 50.2 µM 0.735363543497508 0.30051292769897 no 1014 0.23105905918623 1156 5384001 An antioxidant and salicylic acid derivative. SGTC_646 4092-0839 27.3 µM 0.734917763995559 0.30065102098288 no 1015 0.231194789511142 1163 877796 SGTC_1796 st049173 110.4 µM 0.734154413546674 0.30088755768383 no 1016 0.231427316675118 1101 94134 SGTC_780 0109-0199 192 µM 0.733298375036564 0.301152915092521 no 1017 0.231688232959255 1169 610414 SGTC_833 3852-0053 558 µM 0.732971281492406 0.301254336373886 no 1018 0.231787972712315 1172 3123681 SGTC_2087 5276107 200 µM 0.731182208929495 0.301809342714151 no 1019 0.232333932796809 1150 144405 SGTC_1625 st003711 30.1 µM 0.729675361355962 0.302277153409252 no 1020 0.232794322524761 1169 24207034 YER133W GLC7 SGTC_2343 7990716 14.84 µM 0.728812049613705 0.302545320704649 no 1021 0.233058319888696 1129 6456862 SGTC_1375 2910-0797 186 µM 0.728133647234949 0.30275612509028 no 1022 0.233265889280738 1125 742508 SGTC_1212 0520-0165 585 µM 0.726429886328501 0.303285835645107 no 1023 0.233787637644607 1184 5403258 SGTC_330 1488-0319 80.1 µM 0.725723530088441 0.30350556789648 no 1024 0.234004136976917 1111 6846614 SGTC_1293 1000-1278 195 µM 0.725432998890452 0.303595966543305 no 1025 0.234093217482752 1164 678847 SGTC_3288 9119690 36.221 µM 0.724944790042187 0.303747899565984 no 1026 0.234242950717804 1128 17595618 YKL019W RAM2 SGTC_3174 9107204 49.47 µM 0.723153811773543 0.304305551209161 no 1027 0.234792695960863 1167 3938802 SGTC_3193 9111931 49.47 µM 0.721577786609615 0.304796650292535 no 1028 0.23527705017219 1186 17087244 SGTC_1735 st034310 56.75 µM 0.718842193534916 0.305649913068882 no 1029 0.236119078485128 1131 871153 SGTC_2723 salbutamol 83.58 µM 0.718524982620565 0.305748923220356 no 1030 0.236216824781803 1117 9884233 β2-adrenoceptor agonist SGTC_3020 9089140 49.47 µM 0.718239926777236 0.305837909015418 no 1031 0.236304681729036 1179 17217859 SGTC_483 fpl-64176 144 µM 0.718162953498113 0.305861939706307 no 1032 0.236328408717396 1165 3423 SGTC_3269 9137823 49.47 µM 0.718146757288754 0.30586699619212 no 1033 0.236333401360717 1104 17682936 SGTC_2634 4'-methoxyflavone 100 µM 0.718014984582768 0.305908137244159 no 1034 0.236374023771818 1130 77793 From seeds of Psoralea corylifolia (Fabaceae) SGTC_1695 st026914 34.495 µM 0.717224022101762 0.306155136870476 no 1035 0.236617939578862 1127 3289191 SGTC_351 caspofungin 25 nM 0.716325898294347 0.30643570741491 no 1036 0.236895069439595 1225 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1 SGTC_3013 9080133 71.4286 µM 0.710499668329031 0.308258550928444 no 1037 0.238697168270116 1238 17050193 SGTC_1979 st071809 45.3 µM 0.709393741816997 0.308605096892564 no 1038 0.239040085125809 1194 4976333 SGTC_1612 st002233 45.4 µM 0.709368958929177 0.308612864652474 no 1039 0.239047772689549 1211 1035021 SGTC_2961 9083290 32.55 µM 0.708390340832733 0.308919663702516 no 1040 0.239351444558132 1133 17741490 SGTC_1427 4048-4900 550 nM 0.707916723128274 0.3090681918587 no 1041 0.239498486992649 1166 24132586 SGTC_1239 0337-0584 35.4 µM 0.706717065344038 0.30944454834621 no 1042 0.239871161147252 1218 914301 YML130C ERO1 SGTC_1271 0832-2808 169 µM 0.706091795847584 0.309640787110109 no 1043 0.240065526684732 1193 3663794 SGTC_1887 st057648 70.8 µM 0.704322708018586 0.310196303362612 no 1044 0.240615913927938 1172 688672 SGTC_1623 st003709 20.3 µM 0.703757211764501 0.310373967909184 no 1045 0.240791992266059 1181 16192618 SGTC_2949 9072542 2.23 µM 0.703380880808102 0.310492226056853 no 1046 0.240909209125865 1207 16457352 SGTC_2161 5662504 8.5105 µM 0.693529623996105 0.313594820978316 no 1047 0.243988620813314 1171 2859334 SGTC_1663 st014140 55.4 µM 0.692757723734419 0.313838488226003 no 1048 0.244230803591917 1275 4207120 SGTC_1711 st032263 62.8 µM 0.692420265861412 0.313945039724773 no 1049 0.244336721293063 1197 3958979 SGTC_3330 9141424 71.43 µM 0.692231647695674 0.314004602209775 no 1050 0.244395933548337 1202 27261020 SGTC_1515 3460-0031 42.1 µM 0.691555224298236 0.314218245328722 no 1051 0.24460834440473 1173 2876596 SGTC_3351 9150312 21.596 µM 0.690544642050055 0.314537545925905 no 1052 0.244925873155098 1188 4904905 SGTC_3072 9116419 49.47 µM 0.689857186317864 0.314754831741966 no 1053 0.245142001029458 1184 17170162 SGTC_1065 prochlorperazine maleate 2.48 µM 0.689072886889448 0.315002805528296 no 1054 0.24538870060585 1248 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine. SGTC_1642 st009582 77.7 µM 0.688409383913741 0.315212651952355 no 1055 0.245597508073502 1207 6739311 SGTC_2635 hydroquinidine 100 µM 0.686595378517209 0.315786672622794 no 1056 0.246168870789847 1194 442912 An experimental heart treatment. SGTC_903 1134-0042 114 µM 0.686068854239521 0.315953368348417 no 1057 0.24633484509957 1210 701009 SGTC_909 3448-9333 149 µM 0.685892034736205 0.316009357175761 no 1058 0.24639059671231 1171 3344074 SGTC_1555 citronellol 128 µM 0.682657481564225 0.317034302555939 no 1059 0.247411651356524 1190 8842 A terpine precursor. SGTC_1321 1326-2144 215 µM 0.681936314229429 0.31726301352118 no 1060 0.247639610889037 1196 3513030 SGTC_3143 9086658 49.47 µM 0.679631271687824 0.317994502349625 no 1061 0.248368981855667 1269 25236626 SGTC_3107 9121808 49.47 µM 0.677549174643454 0.318655852046656 no 1062 0.249028790515122 1174 662681 SGTC_1774 st048371 48.465 µM 0.676754379304881 0.318908460502151 no 1063 0.249280903876669 1204 4242727 SGTC_230 MPP+ 141.667 µM 0.67658461089868 0.318962428617008 no 1064 0.249334772913397 1196 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death. SGTC_3126 9127922 49.47 µM 0.676408420183022 0.319018442395169 no 1065 0.249390686349918 1261 45595682 SGTC_2887 9044784 58.44 µM 0.676000949923863 0.319147999379945 no 1066 0.249520020972763 1239 6465546 SGTC_3250 9135583 49.47 µM 0.675660084194987 0.319256396128867 no 1067 0.249628242105923 1237 7699353 SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM 0.674006794495056 0.319782368366894 no 1068 0.250153497000828 1323 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W SGTC_1322 1348-1070 12 µM 0.672360624450318 0.320306435877445 no 1069 0.250677071817022 1213 6758089 SGTC_36 0335-0881 14.2 µM 0.669902944052113 0.321089519425516 no 1070 0.251459831436208 1192 23828853 SGTC_2026 5148700 152 µM 0.669893998436218 0.321092371197608 no 1071 0.25146268293017 1225 79838 SGTC_1130 3454-2858 15.9 µM 0.669388641457022 0.321253491034883 no 1072 0.25162379767006 1215 715628 YIL048W NEO1 SGTC_1025 k007-0731 70 µM 0.669378441776938 0.321256743282253 no 1073 0.251627050029321 1214 6256118 SGTC_2233 sulbentine 40.3845 µM 0.669033260839423 0.321366814990308 no 1074 0.251737130534619 1232 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58 SGTC_2972 9093619 59.92 µM 0.66817064319693 0.32164195611282 no 1075 0.252012336202468 1234 25236256 SGTC_2195 6536160 144.242 µM 0.665130206667978 0.322612515350949 no 1076 0.252983607896286 1144 3834386 SGTC_853 0419-0306 21 µM 0.663944312034847 0.322991401529415 no 1077 0.253362976872285 1199 762713 SGTC_343 4130-2827 29.8 µM 0.66380682758202 0.323035338876386 no 1078 0.253406977632906 1262 1118244 SGTC_388 3',4'-dichloroisocoumarin 16.7 µM 0.663482168213271 0.323139103472317 no 1079 0.253510898112884 1247 1609 A potent and irreversible inhibitor of serine proteases. SGTC_2721 ifenprodil 61.44 µM 0.660857272830873 0.323978552928823 no 1080 0.254351924685652 1256 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor. SGTC_2159 5658611 73.75 µM 0.660326760856806 0.324148321229925 no 1081 0.254522080246579 1270 793844 SGTC_2223 6903751 107.57 µM 0.660169185808936 0.324198753619006 no 1082 0.25457263210012 1228 5598863 SGTC_338 4055-0136 114 µM 0.660024593222899 0.324245033768537 no 1083 0.254619023660332 1213 2900563 SGTC_972 1319-0219 195 µM 0.657755796595669 0.324971569000929 no 1084 0.255347531255036 1225 23903702 SGTC_615 k087-0205 167 µM 0.657318925584448 0.325111544482458 no 1085 0.255487934942377 1224 9642773 SGTC_1187 1391-0724 117 µM 0.655667260154018 0.32564096863241 no 1086 0.256019119337587 1285 6997986 SGTC_1458 k015-0034 6.33 µM 0.654540364467549 0.326002385337189 no 1087 0.256381865345015 1227 3598957 SGTC_2614 arthonioic acid 13.39 µM 0.654281930356065 0.326085293095478 no 1088 0.256465092632103 1213 6710684 SGTC_1949 st076024 69.1 µM 0.654079560932738 0.326150220849614 no 1089 0.256530274419618 1244 2921930 SGTC_9 0092-0002 10.449 µM 0.653435820154754 0.326356792242832 no 1090 0.256737676229927 1240 759368 SGTC_3208 9114115 49.47 µM 0.652298678272506 0.326721822339849 no 1091 0.257104256269244 1231 650895 SGTC_2153 5569715 200 µM 0.650094171633844 0.327429956020603 no 1092 0.257815696901964 1284 2054701 SGTC_1744 st037937 38.9 µM 0.649468374083424 0.327631088638355 no 1093 0.258017840944067 1304 1016152 SGTC_2250 alverine citrate 130 µM 0.648163364134607 0.328050682406521 no 1094 0.258439647306968 1211 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1 SGTC_771 0250-0039 27.3 µM 0.647733503824534 0.328188940947389 no 1095 0.258578665272247 1266 3005115 SGTC_3257 9139206 32.98 µM 0.6470072629617 0.328422579610292 no 1096 0.258813621439443 1242 4910041 SGTC_2455 5377712 9.75 µM 0.646583132610202 0.328559057466972 no 1097 0.258950888762703 1219 2243908 SGTC_839 0122-0028 230 µM 0.645264007229682 0.328983675478419 no 1098 0.259378056601419 1276 759448 SGTC_3322 9139058 2.11 µM 0.642600564403028 0.329841693168143 no 1099 0.260241658381654 1325 4908926 YPR165W RHO1 SGTC_1935 st074532 41.6 µM 0.642036991393141 0.330023361028421 no 1100 0.260424582542055 1332 2829742 SGTC_921 1561-0023 372 µM 0.641228165689198 0.330284156187542 no 1101 0.260687226335179 1271 24050882 SGTC_534 k292-0788 63.4 µM 0.641029371621171 0.330348267337387 no 1102 0.260751800078092 1332 4146317 SGTC_1874 staurosporine 7.6 µM 0.639728072478067 0.330768059648946 no 1103 0.261174700759874 1302 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1 SGTC_2688 kanamycin b 96.69 µM 0.63826845566357 0.331239177774635 no 1104 0.261649471126263 1370 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis. SGTC_1814 st052110 31.539 µM 0.637319976508085 0.33154546014174 no 1105 0.261958220705876 1264 674163 SGTC_2735 sertaconazole 140 nM 0.63727799502701 0.331559019383888 no 1106 0.261971890861874 1352 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C SGTC_2051 5263410 176 µM 0.635789367204334 0.332039961216885 no 1107 0.262456859341578 1330 227584 SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM 0.6340790415575 0.332592870314682 no 1108 0.263014619887001 1296 551469 SGTC_3068 9116768 49.47 µM 0.632827464141523 0.332997707589617 no 1109 0.263423159909361 1269 41904888 SGTC_1347 1493-0251 600 nM 0.631702793483004 0.33336166152981 no 1110 0.263790551161532 1313 3986378 SGTC_1232 0279-0259 161 µM 0.631391174654884 0.333462532077131 no 1111 0.263892392531263 1312 1560000 SGTC_1848 st056003 16.4 µM 0.631042002619504 0.333575572848419 no 1112 0.26400653061904 1335 146492 SGTC_1931 st074438 57.1 µM 0.63065857392311 0.333699721260995 no 1113 0.264131895570469 1265 2787313 SGTC_1360 1598-0022 39.8 µM 0.629444702652827 0.33409287444492 no 1114 0.264528979959393 1351 761525 SGTC_1026 k007-1105 30.6 µM 0.628980404042218 0.334243301399551 no 1115 0.264680942666886 1304 7066794 SGTC_311 1315-0136 58 µM 0.628840239329179 0.334288718250378 no 1116 0.264726826627897 1356 6759207 SGTC_1679 SEC14.276 6.7 µM 0.62758923808166 0.334694181133961 no 1117 0.265136530262563 1329 1005053 YMR079W SEC14 SGTC_3 0833-0587 95.581 µM 0.626742071590261 0.334968866392704 no 1118 0.265414160545391 1232 5382644 SGTC_812 4251-0442 148 µM 0.626650675998204 0.334998505778652 no 1119 0.265444121186117 1285 5723007 SGTC_3030 9087619 49.47 µM 0.626603546196902 0.335013790269336 no 1120 0.265459571606675 1259 25236973 SGTC_623 k072-0108 16.9 µM 0.625091096235195 0.335504432256503 no 1121 0.265955635670969 1295 5382803 SGTC_2274 7947094 46.08 µM 0.623112394735213 0.336146750912173 no 1122 0.266605332588422 1297 2971028 SGTC_412 gemfibrozil 100 µM 0.621641572935704 0.3366245138552 no 1123 0.267088789129781 1292 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels. SGTC_2317 5986382 200 µM 0.620115263871341 0.337120579536622 no 1124 0.267590951807105 1366 877883 SGTC_2305 7443522 69.23 µM 0.618716397352273 0.337575474017382 no 1125 0.26805160293746 1295 5415886 SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM 0.617818543870982 0.337867570268121 no 1126 0.268347479103046 1294 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1 SGTC_1142 3253-1408 9.78 µM 0.616346019359934 0.338346834068317 no 1127 0.268833086125467 1307 256655 SGTC_2885 9057732 51.95 µM 0.615835101663981 0.338513184148008 no 1128 0.269001678899032 1305 6471414 SGTC_3017 9080681 49.47 µM 0.615412242456621 0.338650887035235 no 1129 0.26914125423383 1308 16451914 SGTC_2726 cimetidine 79.27 µM 0.615183241303468 0.338725469609201 no 1130 0.269216856998257 1307 2756 A P450 inhibitor, histamine H2-receptor antagonist. SGTC_233 rapamycin 362 pM 0.614246199075035 0.339030717427093 no 1131 0.269526324380911 1332 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C SGTC_60 0986-0278 202 µM 0.612773834949187 0.339510563443315 no 1132 0.270012946933607 1149 3110598 SGTC_215 1287-0124 461.5 µM 0.612106555329307 0.339728116788587 no 1133 0.270233630342866 1365 5560863 SGTC_1020 4335-0961 93.3 µM 0.611830307847914 0.33981819745992 no 1134 0.270325017588098 1264 669075 SGTC_1209 2323-2347 50.3 µM 0.611421986495789 0.339951362436937 no 1135 0.270460125348151 1301 5412760 SGTC_1962 st076595 64.5 µM 0.609302778998154 0.340642815578212 no 1136 0.271161882710186 1339 279619 SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM 0.609064452381394 0.340720610138089 no 1137 0.271240859278014 1304 2374 Ca(2+)-ATPase inhibitor. SGTC_1578 josamycin 24.2 µM 0.606588071707878 0.341529350580915 no 1138 0.272062159146495 1258 5282165 A P450 substrate. SGTC_1783 st039459 87.517 µM 0.606447378223 0.341575320382078 no 1139 0.272108857702751 1423 729761 SGTC_1662 st014054 52 µM 0.605820870058698 0.341780052455061 no 1140 0.272316854768804 1320 2838777 SGTC_2140 5586273 200 µM 0.60521394627053 0.341978429078222 no 1141 0.27251842523321 1327 854421 SGTC_1175 0741-0056 27.6 µM 0.604651884314545 0.342162181262369 no 1142 0.272705162311345 1397 765927 SGTC_1971 st069429 63.5 µM 0.601082936952068 0.343329830590223 no 1143 0.273892373796365 1327 1246522 YGL099W LSG1 SGTC_1899 st063254 59.6 µM 0.600930674758889 0.343379679450674 no 1144 0.273943080639054 1271 3093813 SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM 0.599197645173685 0.343947244865922 no 1145 0.274520546456409 1359 66535 A nucleotide analog. SGTC_2286 7945697 125 µM 0.598392006409972 0.344211210604555 no 1146 0.274789199107632 1297 1245733 SGTC_726 3448-4391 34.2 µM 0.595227906453707 0.345248654430991 no 1147 0.275845569397736 1448 1356692 SGTC_3138 9097216 49.47 µM 0.595029965149359 0.345313594110756 no 1148 0.275911720581443 1332 25237486 SGTC_170 4197-0004 226 µM 0.593444307524498 0.345833973657193 no 1149 0.276441922025502 1377 218692 SGTC_125 0133-0007 11.75 µM 0.593335078682341 0.345869831007819 no 1150 0.276478463611457 1420 26541 SGTC_3234 9132280 49.47 µM 0.591523611327763 0.346464695992759 no 1151 0.277084819811724 1341 17612295 SGTC_627 1391-0720 175 µM 0.590937038625796 0.346657400977189 no 1152 0.277281303895281 1323 997839 SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM 0.589854630607754 0.347013105413154 no 1153 0.27764405658216 1341 6857784 SGTC_1330 1469-0054 61.8 µM 0.588086554995284 0.347594426085762 no 1154 0.278237098575549 1390 7102664 SGTC_823 0417-1665 178 µM 0.587950677083179 0.347639115861348 no 1155 0.278282699833252 1379 3429856 SGTC_1873 rapamycin 2 nM 0.586853400010223 0.348000084039784 no 1156 0.278651084564802 1364 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1 SGTC_1676 st018489 23.4 µM 0.586330320131546 0.348172208685515 no 1157 0.278826779758256 1378 3696235 SGTC_175 3793-3120 23.7 µM 0.586223911988472 0.348207227175136 no 1158 0.278862527358638 1353 5322297 SGTC_77 0828-0286 12.516 µM 0.585725173853233 0.348371377123207 no 1159 0.279030107142 1321 745345 SGTC_1227 3909-8010 46.6 µM 0.584850011676954 0.348659488351193 no 1160 0.279324286568733 1369 15982272 SGTC_16 erodoxin 22.806 µM 0.583867463400995 0.348983056078033 no 1161 0.279654742513481 1382 3967339 Erodoxin inhibits Ero1. YML130C ERO1 SGTC_3314 9135860 59.4275 µM 0.582133666630251 0.34955428888118 no 1162 0.280238324822477 1356 25252478 SGTC_2980 9014342 25.29 µM 0.580869610990559 0.349970971324311 no 1163 0.280664167483295 1361 2996599 SGTC_1372 2752-0194 270 µM 0.57952617277531 0.350414019496729 no 1164 0.281117095884896 1323 823334 SGTC_510 ag-490 170 µM 0.57937829273203 0.350462800830835 no 1165 0.28116697390605 1476 5328779 SGTC_2940 9060638 45.86 µM 0.578655475158629 0.350701272845595 no 1166 0.281410832383788 1405 4027022 SGTC_2932 9016711 44.54 µM 0.577798152686245 0.350984197001272 no 1167 0.281700201314418 1416 7117328 SGTC_2452 5863136 48.41 µM 0.577372352250342 0.351124745711407 no 1168 0.281843973481851 1341 2184096 SGTC_2882 9058044 58.44 µM 0.576347950864528 0.351462964738191 no 1169 0.282190008966823 1293 18076804 SGTC_2334 9017922 200 µM 0.575557596504298 0.351723990599763 no 1170 0.282457124708203 1463 3163164 SGTC_1116 jasmonic acid  1.58368 µM 0.575403038487839 0.351775043777925 no 1171 0.282509374829125 1421 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid. SGTC_2057 5236571 38.335 µM 0.575053118099665 0.351890638391435 no 1172 0.282627686622758 1423 54684039 YBR257W POP4 SGTC_313 3474-0040 5.03 µM 0.574154689672754 0.352187492829509 no 1173 0.282931563820719 1326 1043375 YIL048W NEO1 SGTC_2245 6637752 200 µM 0.572839345151525 0.352622265155745 no 1174 0.283376738128146 1400 681890 SGTC_2660 2',4'-dihydroxychalcone 17.14 µM 0.568745127916722 0.353976793030664 no 1175 0.284764558800083 1408 5357218 A potent inhibitor of glutathione S-transferases. SGTC_2558 carylophyllene oxide 100 µM 0.567738587045825 0.354310080282311 no 1176 0.285106242988624 1427 6708694 An oxygenated terpenoid and antifungal agent. SGTC_1122 capsaicin 818.572 nM 0.566616657765946 0.354681706643427 no 1177 0.285487327535083 1482 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_1424 4048-1941 275 µM 0.56417449409184 0.355491123625248 no 1178 0.286317692147275 1475 X1424 SGTC_877 0771-0151 33.1 µM 0.564047033519919 0.355533386378428 no 1179 0.286361061718283 1429 6166523 SGTC_2482 5981709 142.65 µM 0.563769973202455 0.355625258810145 no 1180 0.286455344661894 1411 877755 SGTC_1492 4158-0558 28.5 µM 0.563749118617197 0.355632174472205 no 1181 0.286462442021969 1464 3967268 SGTC_455 paf C-16 10 µM 0.561635180013576 0.356333431255778 no 1182 0.287182303092185 1380 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis. SGTC_1006 4099-6547 255 µM 0.561189898842339 0.35648120642275 no 1183 0.287334044130033 1425 3146833 SGTC_496 calpeptin 138 µM 0.560291977306256 0.356779264570552 no 1184 0.287640149360158 1344 73364 A calpain inhibitor. SGTC_3209 9113616 49.47 µM 0.560227146838547 0.356800787933201 no 1185 0.287662256303815 1447 16649353 SGTC_1300 1094-0077 113 µM 0.560080463171334 0.356849487795428 no 1186 0.287712277841575 1370 5532636 SGTC_2578 7,8-dihydroxyflavone 64.44 µM 0.559890488884519 0.356912563871938 no 1187 0.287777068298934 1299 1880 Intensifies effect of antibiotics on Staphylococcus aureus. SGTC_554 4483-2211 187 µM 0.559712583692316 0.356971636262999 no 1188 0.287837748857904 1395 747107 SGTC_2749 bexarotene 57.39 µM 0.55970856169111 0.356972971784904 no 1189 0.287839120766759 1372 82146 An retinoic acid receptor inhibitor. SGTC_671 0560-0003 407 µM 0.559516275849487 0.357036823127627 no 1190 0.287904713273276 1399 3238678 SGTC_2301 7769476 200 µM 0.557056809614575 0.357853877698096 no 1191 0.288744307732919 1461 977820 SGTC_1106 tegaserod maleate 11.7 µM 0.556898912837712 0.357906354584601 no 1192 0.288798248730168 1434 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation. SGTC_1021 4476-0760 85.3 µM 0.556519270400263 0.358032539479352 no 1193 0.288927962313147 1370 746768 SGTC_2470 5664817 21.68 µM 0.556450909021055 0.358055262964386 no 1194 0.288951322465335 1430 2859561 SGTC_3184 9108758 49.47 µM 0.556449358148049 0.358055778484096 no 1195 0.2889518524332 1407 902885 SGTC_662 k832-1615 104 µM 0.555570451548921 0.358347974043724 no 1196 0.289252267949699 1431 5878478 SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM 0.555517862263402 0.358365460167119 no 1197 0.289270247935031 1402 756377 SGTC_3161 9100388 49.47 µM 0.555352194973736 0.35842054706817 no 1198 0.28932689209704 1451 25236368 SGTC_2489 cantharidin 73.42 µM 0.554151721554672 0.358819810761435 no 1199 0.289737507834369 1370 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_1244 0416-0015 52.5 µM 0.553737889062608 0.358957482490931 no 1200 0.289879120457203 1406 96201 SGTC_773 4358-1457 44.6 µM 0.553377042499078 0.359077542080093 no 1201 0.290002627893264 1491 1186886 SGTC_2511 berberine 10.47 µM 0.552711060542437 0.359299161780443 no 1202 0.290230639189027 1403 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_1900 st060200 72.8 µM 0.551126240222226 0.359826734815072 no 1203 0.290773569305629 1414 688945 SGTC_543 3844-1095 191 µM 0.550936786839592 0.359889820112967 no 1204 0.290838504294205 1467 4230703 SGTC_1891 st059073 26.2 µM 0.550346904463572 0.360086267041231 no 1205 0.291040729385417 1485 688754 SGTC_3145 9085516 49.47 µM 0.550346308059614 0.360086465678734 no 1206 0.29104093387949 1393 25236195 SGTC_874 0599-0792 117 µM 0.549535237045659 0.360356634841641 no 1207 0.291319094754874 1452 765305 SGTC_133 0724-0033 378.92 µM 0.548315504263845 0.360763061219261 no 1208 0.291737641664957 1308 280309 SGTC_145 3737-0113 38.366 µM 0.548039565212112 0.360855028528831 no 1209 0.291832368011686 1408 6849351 SGTC_2261 9010538 184.68 µM 0.547348802991789 0.361085286898068 no 1210 0.292069560654126 1343 6457250 SGTC_1600 coumarin 106 71.1 µM 0.546324634389908 0.36142677544273 no 1211 0.292421402819081 1452 100336 A hepatotoxic, DNA x-linker. SGTC_3036 9090181 49.47 µM 0.544106791647349 0.362166648932701 no 1212 0.29318399355608 1443 25236586 SGTC_1416 3966-0321 25.3 µM 0.542021911160154 0.362862636108863 no 1213 0.293901705794459 1406 582530 YLR208W SEC13 SGTC_1609 st001574 46.4 µM 0.541641106476574 0.36298980760857 no 1214 0.294032884082158 1390 3960012 SGTC_1908 st060353 56.5 µM 0.538940693313934 0.363892055913369 no 1215 0.294963888653009 1556 4227716 SGTC_2137 5261020 140 µM 0.537677511060256 0.364314363489151 no 1216 0.295399853881485 1391 763655 SGTC_2179 6298986 200 µM 0.537073406765803 0.364516386145997 no 1217 0.295608454627744 1505 738374 SGTC_1836 st055642 81 µM 0.53663655770282 0.364662499287074 no 1218 0.295759343341025 1353 8571 SGTC_407 eburnamonine 100 µM 0.535739350357727 0.364962650349366 no 1219 0.296069351826986 1378 3195 SGTC_3196 9111891 49.47 µM 0.535582917665213 0.365014991701744 no 1220 0.296123418657231 1407 18891510 SGTC_3089 9117425 49.47 µM 0.534792371895149 0.36527954158433 no 1221 0.296396719204606 1371 9401657 SGTC_2072 5231554 129 µM 0.532839626391611 0.365933286976252 no 1222 0.297072300301339 1493 789545 SGTC_891 0929-0073 133 µM 0.532261824686634 0.366126799738543 no 1223 0.297272334242515 1494 5603632 SGTC_2272 7805186 180 µM 0.529541519299796 0.36703831968469 no 1224 0.298214925161338 1425 2956062 YPR165W RHO1 SGTC_919 tnp00227 403.569 nM 0.527780632076656 0.367628758031654 no 1225 0.298825800660248 1464 1269246 A methoxyflavone. YNL221C POP1 SGTC_2352 9027995 87.8 µM 0.526491338139469 0.368061266286688 no 1226 0.299273434356371 1466 2997347 SGTC_2333 9017922 200 µM 0.525966080783548 0.368237517811045 no 1227 0.299455887150159 1581 3163164 SGTC_1847 st056231 15 µM 0.524858985063513 0.368609097564537 no 1228 0.299840611714855 1453 5393180 SGTC_1002 4049-0206 172 µM 0.524041235405313 0.368883641666088 no 1229 0.300124929830266 1435 4662749 SGTC_2553 4-methylesculetin 85.09 µM 0.523801381333762 0.368964180868118 no 1230 0.30020834626921 1422 5319502 SGTC_2293 7624732 200 µM 0.522705493263911 0.36933223589638 no 1231 0.300589607462477 1390 894453 SGTC_3062 9077494 49.47 µM 0.521591661283392 0.369706440167401 no 1232 0.30097733522274 1476 16459633 SGTC_218 alverine citrate 93.75 µM 0.519915694714581 0.370269732315464 no 1233 0.301561167951681 1502 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_492 tmb-8 126 µM 0.519119920366749 0.37053728949957 no 1234 0.301838558860463 1389 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1 SGTC_497 capsazepine 133 µM 0.51732344682868 0.371141534315752 no 1235 0.302465194583932 1388 2733484 A calcium channel blocker. SGTC_1788 fluconazole 20 µM 0.51722624950646 0.371174235761694 no 1236 0.302499115031109 1435 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11 SGTC_15 0266-0086 27.098 µM 0.51718225196414 0.371189038772163 no 1237 0.302514470092074 1521 1712902 YIL048W NEO1 SGTC_1310 1188-0297 994 nM 0.514167286791624 0.372203879255512 no 1238 0.303567518531643 1453 1588352 SGTC_1716 st033144 30.6155 µM 0.513412424881325 0.372458105888272 no 1239 0.303831428040154 1534 674617 SGTC_530 4358-1714 28 µM 0.511226448245156 0.373194624564063 no 1240 0.304596250476973 1506 1564641 SGTC_2215 7188065 200 µM 0.509511429812819 0.373772788513859 no 1241 0.305196894382986 1501 940217 SGTC_2890 9046729 58.44 µM 0.509106400924167 0.373909372655858 no 1242 0.305338822692944 1400 903329 SGTC_895 0964-0006 13.7 µM 0.507700778688569 0.374383500352931 no 1243 0.305831601130709 1447 6738897 SGTC_2364 9055074 200 µM 0.507215988557034 0.374547068075046 no 1244 0.306001638891175 1435 6470630 SGTC_2869 9037858 32.47 µM 0.506270837808191 0.374866025917744 no 1245 0.306333266086748 1404 27187042 SGTC_1643 st009866 20.2 µM 0.506084754320695 0.374928833176737 no 1246 0.306398576331772 1488 3156273 YOR207C RET1 SGTC_599 1935-0052 86.5 µM 0.505314772419879 0.3751887542016 no 1247 0.306668884408168 1449 9557311 SGTC_2718 lomofungin 53.02 µM 0.504584096485455 0.375435459221397 no 1248 0.306925491099268 1552 5351222 A RNA synthesis inhibitor. SGTC_484 loperamide 105 µM 0.503028382216154 0.37596089934131 no 1249 0.307472158778535 1477 3955 An opioid-receptor agonist. SGTC_2378 9074213 121.43 µM 0.502127926332975 0.376265132120561 no 1250 0.307788768614013 1449 657714 SGTC_1312 1218-2183 165 µM 0.500741828090369 0.376733596827014 no 1251 0.30827641523108 1484 6744073 SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM 0.499968507644707 0.376995037726314 no 1252 0.308548626179634 1525 688788 SGTC_2897 9048598 12.99 µM 0.49989792990519 0.377018901160024 no 1253 0.308573474984203 1455 6467404 SGTC_2032 5185112 25.99 µM 0.499460228727767 0.377166905236744 no 1254 0.308727599112225 1468 5718189 SGTC_2729 fluphenazine 10.66 µM 0.498389845740287 0.377528920040629 no 1255 0.309104646218582 1417 3372 An atypical antipsychotic. SGTC_2338 7999974 200 µM 0.497739226972309 0.377749018774942 no 1256 0.309333927871484 1555 315925 SGTC_2457 5731572 11.68 µM 0.49739461772766 0.377865613205304 no 1257 0.309455400164151 1614 2865357 SGTC_2541 muurolladie-3-one 83.07 µM 0.497119312897687 0.377958767309115 no 1258 0.309552458109613 1505 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils.  YMR203W TOM40 SGTC_875 0709-0210 25.7 µM 0.495737667484252 0.378426377770451 no 1259 0.310039753836273 1519 6251364 SGTC_140 0062-0056 502.533 µM 0.495513723764611 0.378502187108213 no 1260 0.310118768528981 1389 3758964 SGTC_1349 flufenamic acid 69 µM 0.495485166060581 0.378511854786916 no 1261 0.310128845254494 1450 3371 A non-steroidal anti-inflammatory. SGTC_1968 st069590 43.6 µM 0.495451479358491 0.378523258890115 no 1262 0.310140731955351 1524 6384066 SGTC_1504 k297-0033 30 µM 0.49524458125781 0.378593303308138 no 1263 0.310213742438433 1409 4388117 SGTC_2927 9011802 47.9 µM 0.493574253506191 0.379158931126502 no 1264 0.310803443767953 1426 43912568 SGTC_3009 9080819 71.4286 µM 0.492105134651394 0.379656636987187 no 1265 0.311322511302061 1487 17027216 SGTC_2841 9004761 38.96 µM 0.491818636393321 0.379753719698852 no 1266 0.311423780335399 1379 2991039 SGTC_2471 5466956 24.79 µM 0.489939078063875 0.380390813973436 no 1267 0.312088504673742 1524 724419 SGTC_3109 9122853 49.47 µM 0.487814919470138 0.381111208493641 no 1268 0.312840471351009 1564 1234709 SGTC_315 k915-0449 187 µM 0.48760242797276 0.381183296319727 no 1269 0.312915737731838 1556 20970215 YNL149C PGA2 SGTC_725 1497-0963 19 µM 0.487592691741414 0.381186599438941 no 1270 0.312919186578568 1626 3549977 SGTC_2007 4011539 71.82 µM 0.486456463460004 0.381572136262145 no 1271 0.313321782944718 1496 45595301 SGTC_1702 st027038 51 µM 0.485670915499838 0.381838751495228 no 1272 0.313600253967011 1519 5521182 SGTC_1243 0416-0003 5.65 µM 0.485100320241598 0.382032446866672 no 1273 0.313802592456598 1497 2141977 SGTC_2854 9024559 71.43 µM 0.484538369303579 0.382223236684846 no 1274 0.314001920336265 1462 3163529 SGTC_713 1488-1073 324 µM 0.483683675629004 0.382513471371352 no 1275 0.314305190134291 1511 3312542 SGTC_2254 7938975 95.19 µM 0.482432223865005 0.382938555190956 no 1276 0.314749467245876 1600 2969277 SGTC_2167 5876490 200 µM 0.481931682630883 0.383108614823632 no 1277 0.314927239226609 1690 686534 SGTC_2086 5274770 176.623 µM 0.480016459366375 0.383759522562251 no 1278 0.315607844699194 1509 689278 SGTC_976 1348-1067 47.6 µM 0.477313364071109 0.384678754459263 no 1279 0.316569497993016 1523 5310671 YGL099W LSG1 SGTC_929 2805-0021 398 µM 0.47719731327562 0.384718233995725 no 1280 0.316610812063211 1559 3098024 SGTC_3294 9122953 26.2835 µM 0.47616525582275 0.385069384089336 no 1281 0.316978325001719 1468 16459826 SGTC_2607 solasodine 47.35 µM 0.475292911282492 0.385366266549872 no 1282 0.31728910548538 1508 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity. SGTC_721 1187-1332 279 µM 0.475234967734041 0.385385988689429 no 1283 0.317309752955398 1459 25730 SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM 0.471884097104397 0.386527021039447 no 1284 0.318504759891949 1504 689007 SGTC_2934 9036370 36.88 µM 0.471449612346876 0.38667504310946 no 1285 0.318659847087912 1634 6462800 SGTC_1164 k060-0068 93.7 µM 0.469647170497463 0.387289282334654 no 1286 0.319303558864879 1549 5963676 SGTC_1829 berberine 14.4 µM 0.467623055465297 0.387979400187642 no 1287 0.320027087238075 1611 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_2832 7992762 51.95 µM 0.465387469125337 0.38874203003658 no 1288 0.320827003093278 1378 2985177 SGTC_3160 9100216 49.47 µM 0.464969920970294 0.388884516669277 no 1289 0.320976498509404 1536 17191039 SGTC_1478 0453-0656 35.7 µM 0.463905795956433 0.389247712608503 no 1290 0.321357620048624 1556 5258496 SGTC_1093 fluphenazine 7.97 µM 0.463643745767678 0.389337167681558 no 1291 0.321451503486579 1565 6602611 An atypical antipsychotic. SGTC_2982 9019404 25.97 µM 0.462779647032635 0.389632183299987 no 1292 0.321761160706487 1362 22333232 SGTC_2835 9006588 71.43 µM 0.462083493259804 0.389869906389486 no 1293 0.322010723496347 1519 2345538 SGTC_3180 9109287 49.47 µM 0.460702274568318 0.390341687827316 no 1294 0.322506111452685 1524 18891271 SGTC_210 3551-0445 56.827 µM 0.459776880607283 0.390657864092546 no 1295 0.322838189742876 1568 2865180 YOR207C RET1 SGTC_2659 sanguinarine 24.21 µM 0.457319047219412 0.391497974372386 no 1296 0.323720870555479 1524 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis. SGTC_2359 9039622 200 µM 0.4559080165899 0.391980506793693 no 1297 0.324228062287441 1598 6463596 SGTC_126 0417-1624 672.48 µM 0.455641131601913 0.392071792595179 no 1298 0.324324030214474 1590 41912 YDL195W SEC31 SGTC_774 k060-0086 136 µM 0.455601976717174 0.392085185699312 no 1299 0.32433811071855 1669 5911235 SGTC_686 1319-0111 510 µM 0.455384128231367 0.392159704086208 no 1300 0.324416455887475 1641 4562600 SGTC_2894 9048625 32.47 µM 0.455190842498869 0.392225823721383 no 1301 0.324485974025113 1662 4092861 SGTC_2299 7976368 114.88 µM 0.455161970949931 0.392235700435498 no 1302 0.324496358639559 1650 2979718 SGTC_3034 9090421 49.47 µM 0.454328207941872 0.392520953676399 no 1303 0.324796308129798 1574 17173761 SGTC_2028 5153890 36.43 µM 0.453858553154047 0.392681660925064 no 1304 0.324965318316797 1541 2830968 YPR165W RHO1 SGTC_1354 1498-1681 81 µM 0.452752893500346 0.393060069567114 no 1305 0.325363343705689 1568 5754243 SGTC_1752 st044819 83.042 µM 0.450877667912402 0.393702090708676 no 1306 0.326038859859508 1483 441209 YML126C ERG13 SGTC_1139 k015-0024 46.9 µM 0.450497502315123 0.393832283334058 no 1307 0.32617587737287 1591 2766652 SGTC_1329 1447-1697 50.6 µM 0.449000029931655 0.394345227427073 no 1308 0.326715817524989 1545 2840515 SGTC_3319 9138450 16.7555 µM 0.448027937602026 0.394678306034304 no 1309 0.327066517058789 1535 2029690 SGTC_2618 avocadyne 43.43 µM 0.44693160605514 0.395054046467834 no 1310 0.327462221385119 1615 3015189 SGTC_489 paxilline 115 µM 0.446050344522489 0.39535614777663 no 1311 0.327780440054528 1512 105008 A toxic potassium channel blocker. SGTC_754 3474-0146 171 µM 0.445978109199208 0.395380913235025 no 1312 0.327806529381169 1462 24762078 SGTC_2855 9016525 58.44 µM 0.445853242094856 0.39542372418835 no 1313 0.327851629779469 1522 43811474 SGTC_3301 9125354 19.7965 µM 0.44567632607634 0.395484382383695 no 1314 0.327915533877591 1523 41905162 SGTC_229 benomyl 22.8748 µM 0.444688039036242 0.395823277315557 no 1315 0.328272607158119 1536 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C SGTC_396 dithiazanine 1.25 µM 0.44259681528714 0.396540641249686 no 1316 0.329028694361824 1520 10578 An antihelmenthic. SGTC_643 k048-0106 28.4 µM 0.442084748049487 0.396716351969253 no 1317 0.329213940369772 1637 6763920 SGTC_3237 9133362 49.47 µM 0.440317592289391 0.397322894561194 no 1318 0.329853550451649 1619 43845137 SGTC_939 1165-0479 45.3 µM 0.439965459391245 0.397443787203268 no 1319 0.329981062114932 1569 1377347 SGTC_139 0099-0334 718.624 µM 0.439872499781418 0.397475703311816 no 1320 0.330014727232291 1600 97690 SGTC_1121 fusaric acid 630.51 nM 0.43950090596836 0.397603290611434 no 1321 0.330149312858308 1547 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler. SGTC_1429 4049-0205 9.46 µM 0.435933030377947 0.398828881756219 no 1322 0.331442659703017 1590 22774478 SGTC_1042 0350-0096 82 µM 0.435253758092955 0.399062330198121 no 1323 0.331689122906071 1523 3122515 SGTC_366 0181-0206 4.31 µM 0.435152124394133 0.399097262198016 no 1324 0.331726005356061 1740 274874 SGTC_674 0498-0004 451 µM 0.433786573351176 0.399566687037108 no 1325 0.332221716267437 1540 4231473 SGTC_805 3852-0218 479 µM 0.433742951445945 0.399581684996667 no 1326 0.332237556371721 1527 6615355 SGTC_1767 st044992 70.3 µM 0.433389100713445 0.399703350424744 no 1327 0.332366058681316 1520 9600693 SGTC_1499 4480-0877 67.3 µM 0.432595253838777 0.399976336299466 no 1328 0.332654419033899 1580 2861909 SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM 0.4270677203651 0.401878477589853 no 1329 0.334665001702335 1561 91467 include heat shock SGTC_1013 4112-3890 241 µM 0.426176325010607 0.402185444636638 no 1330 0.334989683725658 1553 705171 SGTC_672 1441-0018 53.7 µM 0.42486964525219 0.402635530884713 no 1331 0.335465851931944 1551 251141 SGTC_1816 st051957 91.6 µM 0.424822058787821 0.40265192449669 no 1332 0.335483197947456 1595 674121 SGTC_428 3448-4153 16.5 µM 0.422933705738486 0.403302602980317 no 1333 0.336171815087038 1523 3834874 SGTC_3163 9099914 49.47 µM 0.421635616918945 0.403750046841455 no 1334 0.336645502465233 1645 16268368 SGTC_2270 7924575 90.91 µM 0.420700122930046 0.404072584470162 no 1335 0.33698703569159 1732 1262135 SGTC_3159 9100096 49.47 µM 0.420264553286173 0.404222781513845 no 1336 0.337146100777294 1523 25236875 SGTC_693 4161-2696 114 µM 0.419025342581342 0.40465017445348 no 1337 0.337598805642052 1692 805759 SGTC_1622 st003707 19.4 µM 0.418566913422158 0.404808311523794 no 1338 0.337766337266367 1637 10140899 SGTC_2136 5328288 199.296 µM 0.418535783281147 0.404819050561154 no 1339 0.337777714853342 1574 262395 SGTC_3042 9091578 49.47 µM 0.417894617942641 0.405040250795908 no 1340 0.338012083863022 1602 25236497 SGTC_1196 1588-0294 184 µM 0.416595017919406 0.405488702152471 no 1341 0.338487327033697 1577 6144269 SGTC_1833 st055984 71 µM 0.416296561730691 0.405591707599176 no 1342 0.338596504104439 1611 676288 SGTC_1288 0973-0013 65.5 µM 0.414681950143877 0.40614906768889 no 1343 0.339187373745299 1635 4315430 SGTC_555 4296-0685 37 µM 0.41415679925757 0.406330389586423 no 1344 0.339379638888201 1638 2908540 YHR072W ERG7 SGTC_2321 7390090 138.78 µM 0.413713234081635 0.406483557563801 no 1345 0.339542066934236 1525 649046 SGTC_1496 4469-0713 57.4 µM 0.41354633811732 0.40654119229856 no 1346 0.339603189878526 1698 746691 SGTC_1539 benzyladenosine 56 µM 0.413458294517598 0.406571597501587 no 1347 0.339635436121093 1577 92208 A nucleotide analog. SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM 0.412310225079764 0.40696812624878 no 1348 0.340056027504325 1683 6710655 SGTC_973 1325-0077 65.9 µM 0.411814451965443 0.407139389560491 no 1349 0.340237713911628 1723 2835149 SGTC_854 0422-0053 192 µM 0.41115541446281 0.407367079542169 no 1350 0.34047928939092 1578 3596728 SGTC_539 4859-0462 2.54 µM 0.41088995734578 0.407458800812678 no 1351 0.340576613325855 1734 46499474 YNL221C | YBR257W POP1 | POP4 SGTC_479 n-linoleoylglycine 10 µM 0.410674879663669 0.407533118601718 no 1352 0.340655474549305 1608 6433346 An anti-infammatory. SGTC_3268 9137683 49.47 µM 0.409337191288746 0.407995417109009 no 1353 0.341146112870733 1611 1953228 SGTC_1852 st056254 31.4 µM 0.409108857052343 0.408074341113629 no 1354 0.341229888339392 1673 442583 SGTC_101 0490-5701 117.494 µM 0.408105917598807 0.408421052478148 no 1355 0.341597957867045 1700 4661669 SGTC_1537 2',6'-dihydroxyflavanone 78 µM 0.407984063368095 0.40846318179205 no 1356 0.341642687517787 1601 5106787 A p450 inhibitor. SGTC_2172 5754775 163.918 µM 0.406396915603088 0.409012011321472 no 1357 0.342225492811612 1569 2263357 SGTC_509 pifithrin 175 µM 0.404485367583817 0.409673253980289 no 1358 0.34292791789594 1664 4817 A p53 inhibitor. SGTC_928 2764-0428 58.7 µM 0.40393905329085 0.409862282316129 no 1359 0.343128768654819 1657 662578 SGTC_1286 0929-0070 131 µM 0.40344910701857 0.410031824767903 no 1360 0.343308933590367 1698 1420408 SGTC_819 1013-0258 27.7 µM 0.403446419976429 0.410032754646289 no 1361 0.343309921778116 1599 5753198 SGTC_982 1491-0518 27.5 µM 0.403446148608496 0.410032848555963 no 1362 0.343310021576561 1637 3091256 SGTC_1291 0993-0025 5.79 µM 0.402455622283874 0.410375664755033 no 1363 0.343674370929215 1709 4353356 SGTC_1534 6-azauridine 81.6 µM 0.402232395695961 0.410452931825501 no 1364 0.343756501348195 1618 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1 SGTC_2313 7726885 200 µM 0.401780885775282 0.41060922691731 no 1365 0.343922645224119 1625 726423 SGTC_2429 5902844 64.44 µM 0.401140450125345 0.410830945057929 no 1366 0.344158360534832 1745 1927790 YGL093W | YPR107C SPC105 | YTH1 SGTC_2716 st080858 38.6235 µM 0.400171863021429 0.411166322994616 no 1367 0.344514968546434 1695 5296050 SGTC_612 0302-0167 22.4 µM 0.399664590707308 0.4113419943952 no 1368 0.344701787901042 1714 235821 SGTC_723 4182-0001 115 µM 0.396975241695115 0.412273627997775 no 1369 0.345692858999424 1608 744821 YLR208W SEC13 SGTC_138 0850-0259 40.9225 µM 0.396702739146799 0.412368054929908 no 1370 0.345793340017793 1621 6813004 SGTC_1926 methyl fluorone black 53.6 µM 0.394268353795827 0.413211836785046 no 1371 0.346691462479675 1558 72721 Reacts with homocysteine. SGTC_482 fipronil 114 µM 0.394104346896092 0.413268697648727 no 1372 0.346752000919056 1682 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels. SGTC_591 4299-0174 154 µM 0.393119050864327 0.413610336063682 no 1373 0.347115776988228 1655 5509088 SGTC_448 monastrol 171 µM 0.392292347980101 0.413897034869344 no 1374 0.347421108442124 1660 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity SGTC_2438 5259590 200 µM 0.392023542307594 0.413990266001818 no 1375 0.347520409502429 1764 1201127 SGTC_3211 9128781 49.47 µM 0.391577575438257 0.414144953473753 no 1376 0.347685179786494 1581 17194361 SGTC_636 0kpi-0074 126 µM 0.391567503801209 0.414148447062203 no 1377 0.347688901261885 1637 616434 SGTC_1463 k081-0032 34.1 µM 0.390197926391709 0.414623580936859 no 1378 0.348195097422377 1552 977755 SGTC_1031 k035-0009 16 µM 0.389636142732284 0.414818511131802 no 1379 0.348402811111501 1764 5180959 SGTC_2258 7960471 200 µM 0.389587776816632 0.414835294333869 no 1380 0.348420696034559 1617 2974708 SGTC_2903 5923464 63.88 µM 0.389407053145559 0.414898007680029 no 1381 0.348487527668675 1669 2876576 SGTC_3165 9101544 49.47 µM 0.389159982013597 0.414983747923636 no 1382 0.348578902211514 1693 5002184 SGTC_3182 9108849 49.47 µM 0.388851671334309 0.415090745595505 no 1383 0.348692937354239 1654 17133045 SGTC_1802 st050112 57.9 µM 0.388667517664534 0.415154658206096 no 1384 0.348761056957068 1636 4662563 SGTC_1573 oleylamine 1.06 µM 0.38743694417578 0.415581800184734 no 1385 0.349216378900609 1609 5356789 An amine of the fatty acid oleic acid. SGTC_3335 9143315 29.6265 µM 0.386604428430275 0.415870829723609 no 1386 0.349524539499369 1613 4899691 SGTC_3334 9142812 21.919 µM 0.385430904565623 0.416278326379429 no 1387 0.349959094686642 1675 45283678 SGTC_134 0269-0018 6.916 µM 0.385085601584869 0.416398247200522 no 1388 0.350086997632202 1592 4378915 SGTC_2754 granisetron 64.02 µM 0.38202153906971 0.417462710013398 no 1389 0.351222694130137 1776 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients. SGTC_297 0986-0032 24 µM 0.381580237619793 0.417616069253922 no 1390 0.351386372558869 1642 2847425 SGTC_2962 9082311 13.18 µM 0.380574208218918 0.417965727208025 no 1391 0.3517596112291 1588 16459453 SGTC_926 2268-1401 59.4 µM 0.3792241265902 0.418435066638015 no 1392 0.352260718428189 1633 2931578 SGTC_809 3998-0021 90 µM 0.377757734755953 0.418944971466879 no 1393 0.35280528697596 1773 715485 SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM 0.377672955680283 0.418974455659207 no 1394 0.352836780306316 1703 6708739 YPR165W RHO1 SGTC_2602 kawain 100 µM 0.377618176057194 0.418993506981122 no 1395 0.352857130118109 1652 5369129 SGTC_3260 9137109 49.47 µM 0.376961128269789 0.419222030626174 no 1396 0.353101246347581 1753 17478346 SGTC_461 N-acetylfarnesylcysteine 136 µM 0.376836968536837 0.419265216903257 no 1397 0.353147382825976 1669 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ). SGTC_1177 0983-0204 23.6 µM 0.376181293336853 0.419493295455772 no 1398 0.353391060765376 1809 766818 SGTC_3243 9134147 49.47 µM 0.37611746538447 0.419515499643314 no 1399 0.353414785271044 1717 24282180 SGTC_480 am 92016 50 µM 0.375194005231859 0.419836777543758 no 1400 0.353758094118191 1612 2129 K+ channel blocker. SGTC_859 0439-0102 54.6 µM 0.37496376184403 0.41991688907308 no 1401 0.353843708761724 1773 610143 SGTC_961 1252-1571 372 µM 0.373629715489824 0.420381126114673 no 1402 0.354339911382479 1779 6813498 SGTC_254 nsc-64875 3.808 µM 0.372147294274908 0.42089712629327 no 1403 0.354891592644423 1792 56993 SGTC_3320 9137005 35.139 µM 0.371144549214883 0.421246238241685 no 1404 0.355264935679957 1675 4908713 SGTC_2529 gangaleoidin 93.61 µM 0.370730207339658 0.421390512046895 no 1405 0.35541924445225 1667 4565183 SGTC_878 0828-0289 13.7 µM 0.370591094080841 0.42143895363927 no 1406 0.355471058184739 1656 745350 YLR208W SEC13 SGTC_2079 5212404 121 µM 0.370575937266081 0.421444231570672 no 1407 0.35547670361066 1785 758462 SGTC_2750 bromebric acid 70.15 µM 0.37048582271008 0.421475611703556 no 1408 0.35551026903855 1693 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2 SGTC_1207 2099-0101 141 µM 0.369829072995918 0.42170432336132 no 1409 0.355754925780899 1787 5837381 SGTC_2517 totarol 10 µM 0.366669228231239 0.422805100356788 no 1410 0.356932881258975 1613 460178 An antibacterial membrane disruptor. YGL001C ERG26 SGTC_1749 st037932 54.2 µM 0.365665070996772 0.42315503952972 no 1411 0.357307506487524 1654 594497 SGTC_3112 9123419 49.47 µM 0.364854352498725 0.423437611408894 no 1412 0.357610065095373 1702 17015854 SGTC_2211 7117706 200 µM 0.36356245955295 0.423887975558443 no 1413 0.358092381985572 1754 822771 SGTC_1554 st069299 38.7 µM 0.362276032300547 0.424336533124792 no 1414 0.358572883461764 1743 24207999 SGTC_2984 9022109 38.96 µM 0.3617945647957 0.424504438741298 no 1415 0.358752777035918 1713 6459207 SGTC_3324 9138759 60.749 µM 0.36107848849329 0.424754186499737 no 1416 0.359020386848311 1702 45595710 SGTC_1235 benzylparaben 21.5 µM 0.359831023328719 0.425189340202413 no 1417 0.359486750872936 1698 7180 SGTC_855 0428-0020 25 µM 0.359542080389134 0.425290145289506 no 1418 0.359594801888692 1683 6812414 SGTC_499 genistein 192 µM 0.359189949796025 0.42541300159805 no 1419 0.35972649727889 1748 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger. SGTC_876 0720-0963 56.8 µM 0.358635597167173 0.425606426665918 no 1420 0.359933856626002 1833 765861 SGTC_1978 st071761 42 µM 0.358634450755728 0.425606826691088 no 1421 0.359934285491689 1647 5147680 SGTC_2823 7987624 58.44 µM 0.357645375862032 0.425951979832166 no 1422 0.360304358160281 1685 2239440 SGTC_3092 9117248 49.47 µM 0.355861782830878 0.42657453572873 no 1423 0.360972038789002 1781 17141857 SGTC_3220 9131269 49.47 µM 0.354627429026177 0.427005489138135 no 1424 0.361434362317146 1690 17722206 SGTC_1255 0566-0045 221 µM 0.353280900133604 0.427475705911554 no 1425 0.361938931516672 1748 2788469 SGTC_1914 st062367 72.6 µM 0.352878260063312 0.42761633052328 no 1426 0.36208985483814 1684 978205 SGTC_2265 7929201 200 µM 0.350319476716994 0.428510216111066 no 1427 0.363049474974387 1626 1265108 SGTC_1154 4088-0362 150 µM 0.349493419913176 0.428798869425044 no 1428 0.36335945495647 1671 6618304 SGTC_1261 0712-0010 12.7 µM 0.3467964093145 0.42974156421872 no 1429 0.364372137439202 1821 2840123 SGTC_2001 4023502 57.655 µM 0.346572632774644 0.429819799630147 no 1430 0.364456204460256 1744 108941 YCR052W RSC6 SGTC_3223 9129970 49.47 µM 0.345360374993129 0.430243669749765 no 1431 0.364911731390358 1718 17248386 SGTC_2626 ethyl orsellinate 100 µM 0.345024297486488 0.430361194665207 no 1432 0.365038052151576 1677 75653 A natural product. SGTC_2556 citropten 84.59 µM 0.344531618454244 0.430533493634993 no 1433 0.365223260879762 1625 2775 A potential DNA crosslinker. SGTC_3037 9091026 49.47 µM 0.343876948016382 0.430762464453366 no 1434 0.365469414328658 1747 25236398 YIL048W NEO1 SGTC_1973 st070275 50.2 µM 0.343491254499173 0.430897371563701 no 1435 0.365614459488021 1769 17118334 SGTC_39 0986-0283 58.349 µM 0.34325781861382 0.430979026220966 no 1436 0.365702255483242 1857 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2 SGTC_1146 3579-1023 7 µM 0.342082331226533 0.431390250354856 no 1437 0.366144466934469 1833 X1146 SGTC_146 3448-8650 53.125 µM 0.341718595220055 0.431517512257065 no 1438 0.36628133834094 1752 2891488 YIL048W NEO1 SGTC_2068 5226020 147 µM 0.341691765542962 0.431526899554819 no 1439 0.366291434841461 1678 1810509 SGTC_2661 dactinomycin 12.96 µM 0.340836465627835 0.431826176282648 no 1440 0.366613348390073 1733 45006140 An Actinomycin D Classic transcription inhibitor. SGTC_1980 st071811 45.7 µM 0.340695034145296 0.431875668138397 no 1441 0.366666588720261 1794 4974850 SGTC_270 tamoxifen 5.46 µM 0.340054227077543 0.432099922481456 no 1442 0.366907845642338 1857 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  YIL048W NEO1 SGTC_2722 naftopidil 47.16 µM 0.33992290892422 0.432145880773995 no 1443 0.366957291999245 1779 4418 An a1-adrenergic receptor antagonist or alpha blocker.  SGTC_951 1171-0579 82.7 µM 0.339914822422142 0.432148710891238 no 1444 0.366960336951772 1649 1616050 YPR165W | YDR526C RHO1 | YDR526C SGTC_2652 actinonin 100 µM 0.339753141930489 0.432205296625162 no 1445 0.367021219100786 1746 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase. SGTC_1233 0325-0408 14.2 µM 0.339132434793969 0.432422547670833 no 1446 0.367254982647465 1791 12874 SGTC_1155 4088-0394 48.2 µM 0.337840025969146 0.432874963636612 no 1447 0.367741872539562 1676 2326248 SGTC_1474 0330-0125 5.35 µM 0.337753124165466 0.432905387332258 no 1448 0.36777461874174 1709 X1474 SGTC_867 0518-0118 155 µM 0.337068804442165 0.433144976621788 no 1449 0.368032516600493 1754 6848158 SGTC_3169 9102970 49.47 µM 0.336102025207804 0.433483500546045 no 1450 0.368396965639645 1753 17027839 SGTC_991 3996-0057 64.7 µM 0.335805116245644 0.433587474922985 no 1451 0.368508915895647 1721 715343 SGTC_2184 6075246 200 µM 0.33568170503915 0.433630693574326 no 1452 0.368555451679835 1772 2267320 SGTC_2268 7933382 153.85 µM 0.335443129541802 0.433714245053465 no 1453 0.368645418974142 1707 935025 YOR257W CDC31 SGTC_2405 ticlatone 3.52 µM 0.335253615429945 0.433780616865356 no 1454 0.36871689025414 1506 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W SGTC_1323 1348-1351 11.2 µM 0.334841619266939 0.433924912991525 no 1455 0.368872281646128 1702 6989654 SGTC_589 1227-0070 34.1 µM 0.33442690734374 0.434070169169202 no 1456 0.369028718984117 1759 2841384 SGTC_2802 7925815 54.55 µM 0.334220161521623 0.434142586878515 no 1457 0.369106715603044 1677 1262923 SGTC_2023 5144124 124 µM 0.333768198751207 0.434300905430737 no 1458 0.369277241165712 1703 2830192 SGTC_1686 st019653 115.5 µM 0.333508325537931 0.434391941486935 no 1459 0.369375302985126 1838 97252 SGTC_2355 9061122 103.12 µM 0.332574261597421 0.434719181654485 no 1460 0.369727837339789 1844 5302957 SGTC_778 3456-2434 196 µM 0.330927580290031 0.435296189141891 no 1461 0.370349594278181 1879 5539063 SGTC_35 0133-0054 64.071 µM 0.330396858247308 0.435482186905791 no 1462 0.370550057566408 1642 99677 SGTC_1897 st060201 15 µM 0.329262757752893 0.435879693513744 no 1463 0.370978545538432 1693 611878 SGTC_2408 sulbentine 18.36 µM 0.327233301990297 0.436591187041195 no 1464 0.371745717416767 1793 67686 An antifungal agent of unknown mechanism. YDL205C HEM3 SGTC_2633 5,7-dihydroxyisoflavone 100 µM 0.32704369066059 0.436657672144526 no 1465 0.371817420088634 1803 5377381 SGTC_3070 9117005 49.47 µM 0.326650179960346 0.436795658001815 no 1466 0.371966242728647 1804 8779016 SGTC_2241 6772625 37.8075 µM 0.326526012243188 0.436839199428504 no 1467 0.372013205950584 1676 2285411 SGTC_490 phenamil 164 µM 0.325099636937228 0.437339435847469 no 1468 0.372552831864207 1831 4755 Irreversibly blocks amiloride-sensitive Na+ channels. SGTC_1019 4262-0212 3.4 µM 0.323411011668509 0.437931773989771 no 1469 0.373191995580908 1883 4677213 SGTC_2202 7226349 200 µM 0.321374355927762 0.438646379657868 no 1470 0.373963357122751 1725 844334 SGTC_2689 tacrolimus 100 µM 0.320967129219041 0.438789288220769 no 1471 0.37411765055473 1739 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). SGTC_571 k831-0106 44.2 µM 0.320284335180511 0.439028919859329 no 1472 0.374376398467837 1864 4783639 SGTC_277 nystatin 15.5 µM 0.318619963391607 0.439613136958771 no 1473 0.37500735662763 1697 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_1490 4089-0339 670 nM 0.318141389462467 0.439781147310803 no 1474 0.375188844536098 1867 742542 SGTC_549 1661-1316 519 µM 0.318016679501323 0.439824930342616 no 1475 0.375236142396531 1866 2857282 SGTC_3097 9117246 49.47 µM 0.317762924466976 0.439914020644172 no 1476 0.375332388055567 1724 16423892 SGTC_1100 amiodarone 5.07 µM 0.31606866252856 0.440508933132897 no 1477 0.375975196029986 1909 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. SGTC_1692 fluoroquinolonic acid 71 µM 0.315832171594942 0.440591983785609 no 1478 0.376064948810112 1786 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2 SGTC_999 SEC7.066 22.7 µM 0.315588419050321 0.440677587298575 no 1479 0.376157464524797 1793 740511 YDR170C SEC7 SGTC_2815 7968870 71.43 µM 0.315242680335695 0.440799012112302 no 1480 0.376288701060037 1705 2977326 YHR190W ERG9 SGTC_1075 aripiprazole 15.2 µM 0.314694388533272 0.440991585785838 no 1481 0.376496852626252 1740 60795 An atypical antipschotic. YIL048W NEO1 SGTC_3124 9127567 49.47 µM 0.314329974336126 0.441119584807891 no 1482 0.376635217420034 1855 17592030 SGTC_586 0957-0265 8.15 µM 0.314312749788965 0.44112563501319 no 1483 0.376641757818129 1845 6752309 YPR165W | YPR107C RHO1 | YTH1 SGTC_1471 k673-0312 37 µM 0.314073397009956 0.441209710253162 no 1484 0.376732647033138 1859 24099884 SGTC_2187 6125751 200 µM 0.314066641587797 0.441212083206372 no 1485 0.376735212362672 1779 874498 SGTC_2090 5301565 104.445 µM 0.313958573976217 0.441250044020314 no 1486 0.376776251105675 1760 2056344 SGTC_184 1494-0393 24.714 µM 0.31366510849109 0.441353132102629 no 1487 0.376887701830405 1702 3090647 SGTC_3104 9120930 49.47 µM 0.310699709954182 0.442395034273435 no 1488 0.378014458886604 1766 17014836 SGTC_935 2996-0153 430 µM 0.310234499544733 0.442558523777039 no 1489 0.378191318512477 1921 23738523 SGTC_764 1951-2361 146 µM 0.309665213676617 0.44275860196281 no 1490 0.378407779364747 1701 5438930 SGTC_710 3448-4187 58 µM 0.309458144438337 0.442831381040301 no 1491 0.378486523237659 1755 3946412 SGTC_1757 st041620 31.8375 µM 0.307854141703921 0.443395208547667 no 1492 0.379096660868259 1725 5289815 SGTC_1789 tunicamycin 25 nM 0.307793692137413 0.443416459593002 no 1493 0.379119660842379 1881 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_966 1300-0360 30.2 µM 0.305469325752715 0.44423371346851 no 1494 0.380004364359414 1744 70588 SGTC_432 NS 1619 61.3 µM 0.302275894467547 0.445356919137833 no 1495 0.381220876394287 1797 4552 A K+/calcium channel activator. SGTC_454 lyso-paf C-16 6.67 µM 0.301257856235147 0.445715080041517 no 1496 0.381608937399349 1675 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_2732 terfenadine 20 µM 0.301188246610502 0.445739571358352 no 1497 0.381635475902993 1809 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.  SGTC_2699 st077704 54.6 µM 0.298339398732404 0.446742081114858 no 1498 0.382722068392919 1783 645852 SGTC_90 0870-0863 4.608 µM 0.298100715429916 0.44682608933022 no 1499 0.38281314777369 1737 1738164 SGTC_383 2324-0395 7.37 µM 0.296558993722551 0.447368779035379 no 1500 0.383401610694248 1847 3146421 SGTC_2416 tofa 880 nM 0.296276469414182 0.447468238977922 no 1501 0.383509477191096 1659 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_325 2810-4341 181 µM 0.293879793289162 0.448312097813955 no 1502 0.384424879641423 1905 774970 SGTC_2146 5545642 200 µM 0.29330739496232 0.448513671429391 no 1503 0.384643600867726 1847 825326 SGTC_64 000l-0018 272.079 µM 0.293089508742533 0.448590404906795 no 1504 0.384726867824897 1754 6811119 SGTC_1634 st006576 41 µM 0.292873975494958 0.448666311624939 no 1505 0.384809240806761 1937 3915356 SGTC_547 1120-0019 610 nM 0.290534541001063 0.449490336357017 no 1506 0.385703664936647 1789 3676939 SGTC_2418 pentamidine 31.67 µM 0.290284784981934 0.449578321464092 no 1507 0.385799188895693 1837 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM 0.289824922614895 0.449740330205538 no 1508 0.385975090151712 1892 16725076 SGTC_312 4092-0653 6.84 µM 0.28932246768788 0.449917353810947 no 1509 0.386167310225472 1881 1148278 SGTC_2734 clemastine 41.6 µM 0.289153406286226 0.449976919324299 no 1510 0.386231992949284 1854 26987 Clemastine is a selective histamine H1 antagonist. SGTC_2821 7996764 71.43 µM 0.287272294088738 0.450639768537405 no 1511 0.386951917548637 1827 2987135 SGTC_917 harmaline 728.087 nM 0.28407958772441 0.451765099588924 no 1512 0.388174694732968 1849 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7 SGTC_1242 0402-0103 60.1 µM 0.283781807951405 0.45187007772886 no 1513 0.388288798393638 1806 432868 SGTC_69 0096-0274 206.684 µM 0.282728942436451 0.452241277838864 no 1514 0.388692314098446 1882 6741392 SGTC_1903 st060211 78.3 µM 0.282465566191081 0.45233414077012 no 1515 0.388793273095099 1918 688960 SGTC_2649 anisomycin 9.56 µM 0.282323390891286 0.45238427095778 no 1516 0.388847775724537 1818 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_2135 5326629 150.42 µM 0.280567183772535 0.453003561772134 no 1517 0.389521194467723 1774 5020077 SGTC_114 0364-0001 490.298 µM 0.279417536118664 0.453409023705436 no 1518 0.389962207462532 1749 4003655 SGTC_3215 9129942 49.47 µM 0.278367439473623 0.453779418082435 no 1519 0.390365155815111 1970 17682944 SGTC_944 3370-0224 231 µM 0.277883112886095 0.453950265302029 no 1520 0.390551043764573 1755 4580514 SGTC_2784 7567673 72.73 µM 0.27779410566803 0.453981663712741 no 1521 0.390585208083335 1801 3471247 SGTC_468 gf-109203x 121 µM 0.277174356934077 0.454200295801522 no 1522 0.390823114367185 1917 2396 A protein kinase C inhibitor. SGTC_173 1273-0061 2.693 µM 0.276264562956789 0.454521273830172 no 1523 0.391172435894744 1734 2847414 YPL266W DIM1 SGTC_2531 methyl deoxycholate 70.07 µM 0.275110061019263 0.454928628287257 no 1524 0.391615841072948 1787 16667744 Haematoxylin. SGTC_901 1112-0062 60.1 µM 0.274631955976564 0.455097336771552 no 1525 0.391799506337287 1819 1908457 SGTC_2292 7671323 168.05 µM 0.272528669452935 0.455839617320585 no 1526 0.392607775086898 1813 937504 SGTC_572 0960-0087 17.7 µM 0.272178131399498 0.455963342379693 no 1527 0.392742527961752 1742 6796365 SGTC_689 0833-0039 98 µM 0.27178478534656 0.456102181930123 no 1528 0.392893752277646 1927 5374726 SGTC_2501 sodium tetradecyl sulfate 13.37 µM 0.270573755622021 0.456529673272792 no 1529 0.393359441543629 1752 23665772 A membrane-active detergent. SGTC_2779 methotrexate 400 µM 0.268423050373004 0.457288992126313 no 1530 0.394186849345682 1931 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2 SGTC_1731 st035964 63 µM 0.268367424567886 0.457308633217398 no 1531 0.39420825576145 1777 6739575 SGTC_1907 st060210 83.7 µM 0.267408944902393 0.457647082165139 no 1532 0.394577156548771 1926 688793 SGTC_1048 3161-0300 24.5 µM 0.266664400738199 0.45791000951467 no 1533 0.394863782862326 1816 2165101 SGTC_6 0844-0013 19.835 µM 0.265587850063244 0.458290213750391 no 1534 0.39527832194304 1916 1584900 SGTC_551 k048-0028 34.9 µM 0.265566242965929 0.45829784509739 no 1535 0.395286643236636 1923 6836383 SGTC_3055 9094636 49.47 µM 0.265315731301321 0.458386323695164 no 1536 0.395383123406181 1881 25236176 SGTC_2587 piperic acid 92.2 µM 0.264845642800601 0.458552360532743 no 1537 0.395564187042127 1796 5370536 SGTC_3147 9097027 49.47 µM 0.264293870384925 0.458747257627192 no 1538 0.395776741567995 1882 25236841 SGTC_1992 st073643 23.3 µM 0.264124246173684 0.458807174298983 no 1539 0.395842090671431 1810 3161292 SGTC_2082 5219693 150 µM 0.263776623319023 0.458929968681315 no 1540 0.395976024342748 1811 2834649 SGTC_2596 sinensetin 100 µM 0.262840414823374 0.459260694655943 no 1541 0.396336791929912 1794 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets. SGTC_2756 carbadox 75.1 µM 0.262806568488732 0.459272651776361 no 1542 0.396349836266792 1817 2553 A substituted quinoxaline antibiotic. YLR208W SEC13 SGTC_2396 5342950 42.78 µM 0.26139691762188 0.45977068113289 no 1543 0.396893216906549 1829 1886677 SGTC_445 e6 berbamine 66 µM 0.26121113176946 0.459836323960937 no 1544 0.396964847068971 1832 6610268 A calcium/calmodulin antagonist. SGTC_2376 9072922 81.32 µM 0.26091227331541 0.459941920487663 no 1545 0.397080079925502 1889 17087968 SGTC_156 3474-0145 5.642 µM 0.259718930894759 0.460363595729115 no 1546 0.397540294437354 1994 2265471 SGTC_2782 7736369 71.43 µM 0.257842866665422 0.461026605076861 no 1547 0.398264089955899 1810 2950836 YOL077C BRX1 SGTC_2437 5741531 144.16 µM 0.257572778150862 0.461122064510717 no 1548 0.398368320429554 1967 2262990 SGTC_1587 estradiol valerate 56.1 µM 0.25614209712214 0.461627758198382 no 1549 0.398920558571189 1983 13791 A steroid. SGTC_1368 1852-0141 284 µM 0.255880377761249 0.461720273206914 no 1550 0.399021603309802 1854 2838987 SGTC_2105 5350118 200 µM 0.255274140192295 0.461934579682833 no 1551 0.3992556857875 1820 2133313 SGTC_1459 k035-0031 35.7 µM 0.254553160471735 0.462189462175147 no 1552 0.399534120044942 1762 3877128 YMR208W ERG12 SGTC_927 2425-1185 123 µM 0.253671962113581 0.462501006623805 no 1553 0.399874498326298 1793 730375 SGTC_611 3453-1652 23.7 µM 0.253566533112375 0.46253828220526 no 1554 0.399915227223969 1956 1560575 SGTC_481 bay k-8644 50 µM 0.253304816947052 0.462630816251617 no 1555 0.400016337040798 1820 2303 A calcium channel antagonist. SGTC_1000 4048-0884 8.67 µM 0.252804272634005 0.462807797538376 no 1556 0.400209732922404 1874 13040088 SGTC_825 1988-2224 89.6 µM 0.251334557737103 0.463327498309083 no 1557 0.400777729617807 1845 1180859 SGTC_1990 st072050 59.8 µM 0.250702628035666 0.463550972066119 no 1558 0.401022014340254 1811 17233948 SGTC_2532 xanthone 78.9 µM 0.249634949349379 0.46392856890601 no 1559 0.40143483420277 1932 7020 An insecticide. SGTC_1415 3966-0071 78.1 µM 0.246948843354355 0.464878684122225 no 1560 0.402473907557762 1896 2893185 SGTC_2811 7967822 32.47 µM 0.246048636442409 0.465197145629043 no 1561 0.402822291536879 1921 2232244 SGTC_100 0086-0128 49.5915 µM 0.244272662077692 0.46582548800062 no 1562 0.403509827377826 1779 93297 SGTC_2323 6148992 148.28 µM 0.243549747218139 0.466081280841584 no 1563 0.403789776131468 1838 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42 SGTC_801 0866-0028 10.1 µM 0.243204436293968 0.466203469009105 no 1564 0.403923515179476 1866 6849771 SGTC_2049 5262831 67.185 µM 0.242808850578033 0.466343450811195 no 1565 0.404076739475971 1864 763417 SGTC_1594 piperine 70.1 µM 0.239537692188918 0.46750113956689 no 1566 0.405344336426432 1832 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_1236 0330-0013 258 µM 0.239432506087863 0.467538370372747 no 1567 0.405385113340204 1863 4617066 SGTC_2872 9044037 25.97 µM 0.239360835084832 0.467563738613276 no 1568 0.405412898229674 1950 6465195 SGTC_1641 st009299 47.1 µM 0.237723458758584 0.468143330246714 no 1569 0.406047793859063 1961 4046054 SGTC_2388 9080168 200 µM 0.237110760240675 0.468360228138445 no 1570 0.406285432453993 1804 15943073 SGTC_2120 5538279 151.968 µM 0.237040763092438 0.468385008026827 no 1571 0.406312583443997 1900 2058197 SGTC_757 1066-0008 322 µM 0.236847589869841 0.468453394460773 no 1572 0.406387515179572 1958 6842497 SGTC_962 1254-0300 21.5 µM 0.236431024290989 0.468600868554428 no 1573 0.406549112292532 1877 7340576 SGTC_1667 st014849 34.6 µM 0.234958147554712 0.469122336260863 no 1574 0.407120608669315 1936 5348460 SGTC_3307 9126885 69.2785 µM 0.233079005314878 0.469787717869974 no 1575 0.407850028654119 1822 24824909 SGTC_1137 ixabepilone 100 µM 0.232240959034291 0.470084487269152 no 1576 0.408175433286893 1804 154225 A novel microtubule stabilizer. SGTC_2432 5630864 12.22 µM 0.23007123917227 0.470852906434404 no 1577 0.409018206629951 1878 5714970 SGTC_1109 tnp00067 928.257 nM 0.228702801322268 0.471337602814807 no 1578 0.409549958676676 1879 676295 SGTC_2995 9067767 71.4286 µM 0.227919940543006 0.471614908778197 no 1579 0.409854240182054 1908 11673567 SGTC_1500 4488-1866 171 µM 0.227815353086145 0.471651956928201 no 1580 0.409894895240338 2001 2900003 SGTC_441 propafenone 146 µM 0.225772026979802 0.47237581579108 no 1581 0.410689367298482 1908 4932 Slows the influx of sodium ions into the cardiac muscle. SGTC_1066 ketoconazole 628 nM 0.224222946876186 0.472924646384278 no 1582 0.411291914490625 1978 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W SGTC_124 0136-0217 7.121 µM 0.224086520708061 0.472972983906246 no 1583 0.411344990359022 2077 3976905 SGTC_1378 2093-0007 380 nM 0.223846485940123 0.473058032235155 no 1584 0.411438378535445 1883 3618014 SGTC_2905 7799065 20.05 µM 0.223583351197168 0.473151266682221 no 1585 0.411540759777551 2016 1296806 SGTC_2492 derrusnin 100 µM 0.22121795486374 0.473989444240806 no 1586 0.412461364802486 1911 1715307 Part of coumarin class of compounds. SGTC_3206 9114350 49.47 µM 0.220801559315497 0.474137005917539 no 1587 0.412623474694201 2019 17087243 SGTC_301 4119-0100 24.5 µM 0.220731603007488 0.474161797285625 no 1588 0.412650711341695 1894 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1 SGTC_1060 3448-7350 82 µM 0.219498103812313 0.474598945517098 no 1589 0.413131028395986 2012 570178 SGTC_1871 st057448 67.3 µM 0.217991281709797 0.475132999974073 no 1590 0.413717952138373 1980 691747 SGTC_2180 6301957 200 µM 0.217584850961785 0.475277056622508 no 1591 0.413876294445793 2019 845462 SGTC_2287 7945887 168.79 µM 0.214230096146263 0.476466248635227 no 1592 0.415183813759841 2051 1245853 SGTC_2368 9071271 200 µM 0.213900585325323 0.476583064964119 no 1593 0.41531229188676 1863 27209959 SGTC_842 0271-0008 11.1 µM 0.212282267025996 0.477156811117686 no 1594 0.415943414517331 1983 1221709 SGTC_2477 5967686 25.23 µM 0.212274374700803 0.477159609319106 no 1595 0.415946492951918 1896 776118 SGTC_2039 Aminomethylbenzodioxan 200 µM 0.211611215287794 0.477394734609512 no 1596 0.416205179471194 1909 15053 SGTC_3353 9151644 39.2805 µM 0.211284150530148 0.477510699367815 no 1597 0.416332774905394 1928 4909158 SGTC_159 3970-0959 50 µM 0.208474513937612 0.478506967363965 no 1598 0.417429240196151 2004 6615653 SGTC_1571 st070080 73.4 µM 0.207391939825376 0.478890873103367 no 1599 0.417851888427268 1992 4315245 SGTC_1387 3342-1166 1.8 µM 0.206816138061722 0.479095073685624 no 1600 0.418076726137307 1943 3418228 SGTC_103 0844-0104 51.839 µM 0.206475604749399 0.479215841967081 no 1601 0.418209709384381 2019 5375804 SGTC_2488 5268135 45.7 µM 0.204756237604723 0.479825635056084 no 1602 0.418881289930467 1982 1270356 YLR208W SEC13 SGTC_1366 1683-0113 21.9 µM 0.203392230918577 0.480309429180417 no 1603 0.419414235866782 1914 708623 SGTC_304 1310-0298 97 µM 0.202947264755339 0.480467258774116 no 1604 0.41958812548629 1955 1550234 SGTC_1505 k297-0037 20.6 µM 0.200294913011363 0.481408111186657 no 1605 0.420624970385092 1905 4089396 SGTC_1812 st052057 4.327 µM 0.199262610073167 0.481774321942131 no 1606 0.421028662742015 1954 3645418 SGTC_2710 st078562 53.7235 µM 0.199205920718478 0.481794433009745 no 1607 0.421050834088704 2000 17250908 SGTC_2619 obliquin 87.91 µM 0.198319402507054 0.482108939456878 no 1608 0.421397586081373 2010 6708593 A bioactive alkalod. YER133W GLC7 SGTC_3056 9094900 49.47 µM 0.197899968832602 0.482257744121653 no 1609 0.421561664281331 1877 25236784 SGTC_2698 st077697 67.5 µM 0.197458713684624 0.482414293171597 no 1610 0.421734293521274 1887 3154499 SGTC_2296 7971656 126.45 µM 0.197194810748942 0.482507922280513 no 1611 0.421837545655916 1923 666570 SGTC_1737 st035557 69.7 µM 0.196676827524908 0.482691698359297 no 1612 0.422040222427799 1885 5716916 SGTC_404 fumagillin 50 µM 0.196633441640357 0.482707091472641 no 1613 0.422057199419418 1963 12015870 A methionine aminopeptidase binder. SGTC_679 0422-0091 41.4 µM 0.195623354104866 0.483065473147079 no 1614 0.422452489756931 1895 627384 YHR062C RPP1 SGTC_1190 1486-1332 13 µM 0.194235068475249 0.483558062753228 no 1615 0.422995912525197 2037 4150046 SGTC_1153 4055-0057 267 µM 0.192999465198913 0.483996498947366 no 1616 0.423479693462419 1905 882706 SGTC_1172 0370-0043 85 µM 0.192721081039874 0.484095282284331 no 1617 0.423588706332354 1995 376585 SGTC_368 fentichlor 4.58 µM 0.191951023768814 0.484368538627467 no 1618 0.423890284653649 1924 7329 A pesticide. SGTC_1226 3909-7979 35.4 µM 0.191822379435946 0.484414189042127 no 1619 0.423940670116602 2056 6615510 SGTC_2656 pseudo-anisatin 100 µM 0.190645055611122 0.484831980721748 no 1620 0.424401844129688 1992 6708809 A neurotoxin. SGTC_1426 4048-4480 71.7 µM 0.189827007930461 0.48512228750329 no 1621 0.424722345704594 2049 14224343 SGTC_370 0180-0345 38.7 µM 0.188875251715531 0.485460054359906 no 1622 0.425095295357028 1941 3989527 SGTC_1632 st005650 90 µM 0.188713764882055 0.485517365140599 no 1623 0.425158581310184 1974 2759605 SGTC_2805 7950783 58.44 µM 0.187466944046137 0.485959864915434 no 1624 0.425647269517304 1984 1178958 YDL195W SEC31 SGTC_826 1683-5028 118 µM 0.187122781462003 0.486082012129084 no 1625 0.425782183303443 1970 722377 SGTC_1855 st056195 39.6 µM 0.184833160173014 0.486894657444831 no 1626 0.426679948948563 2095 4028379 SGTC_425 3825-7017 13.1 µM 0.182321123373793 0.487786306211979 no 1627 0.427665361222759 2019 3397440 SGTC_813 k007-0158 173 µM 0.18216214512546 0.487842737724853 no 1628 0.427727739859016 2052 6523916 SGTC_189 3970-0742 2.116 µM 0.18189472459352 0.487937662864291 no 1629 0.427832672301032 2088 2891807 SGTC_143 4032-1194 15.74 µM 0.181091586002035 0.488222753672418 no 1630 0.428147844404324 1926 1806963 SGTC_2238 6671620 73.2395 µM 0.180871164520466 0.488300997937103 no 1631 0.428234351450955 2099 729941 SGTC_2047 4141938 200 µM 0.177995596644671 0.489321794738216 no 1632 0.42936321694529 1976 3807862 SGTC_76 0433-0009 400.328 µM 0.177959934056458 0.489334455040476 no 1633 0.42937722070178 1941 2841569 SGTC_2653 dihydrofissinolide 100 µM 0.177590681744081 0.48946554110469 no 1634 0.429522221553307 2026 6857746 SGTC_1070 indatraline 8.81 µM 0.177273010434709 0.489578316615347 no 1635 0.429646974787865 1972 10314472 A monamine transport inhibitor. YGL099W LSG1 SGTC_948 3448-0295 75.3 µM 0.174831582672405 0.490445067484697 no 1636 0.430605985568362 2015 678569 SGTC_3339 9145883 14.936 µM 0.174782035514786 0.490462658099864 no 1637 0.430625452313879 2080 2030670 SGTC_3014 9081533 49.47 µM 0.174370426904447 0.490608791286592 no 1638 0.430787177085961 2111 21367265 SGTC_3175 9106517 49.47 µM 0.174343640015378 0.490618301465517 no 1639 0.430797702301237 1990 41468073 SGTC_2379 9035213 200 µM 0.173144897631148 0.491043897682321 no 1640 0.431268767328369 2129 646551 SGTC_459 nigericin 15.3 µM 0.171789669572494 0.491525064138391 no 1641 0.43180144363695 2012 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification. SGTC_3315 9136395 68.55 µM 0.170775769454785 0.491885052042019 no 1642 0.432200041169023 2126 16876844 SGTC_3082 9117008 49.47 µM 0.16962921130406 0.492292148477053 no 1643 0.432650874082592 1975 41448529 SGTC_1511 0906-3109 28.5 µM 0.169129055269156 0.492469736199725 no 1644 0.432847565665079 2095 2882180 SGTC_1205 4161-2785 76 µM 0.168664200315732 0.492634791095571 no 1645 0.433030389648622 1904 3498106 SGTC_168 3970-0862 530.542 µM 0.167179948147267 0.493161809136188 no 1646 0.433614230715609 2027 3135186 SGTC_1933 st074711 15.9 µM 0.164362687358388 0.494162174772308 no 1647 0.434722817616135 2127 17250958 SGTC_2025 5147754 141 µM 0.164074601824695 0.494264471654896 no 1648 0.434836207820902 2097 315777 YLR208W SEC13 SGTC_456 gingerol 170 µM 0.163658331775774 0.494412286504191 no 1649 0.435000060799864 2051 442793 A herb. SGTC_2312 7706453 155.7 µM 0.161290670036029 0.495253042131936 no 1650 0.435932235643046 2002 976098 SGTC_185 k048-0037 25.491 µM 0.160432331923506 0.495557843016461 no 1651 0.436270261136834 2132 6827589 SGTC_2345 9052315 157.45 µM 0.160394859261783 0.495571149838202 no 1652 0.436285019454778 1992 6469265 SGTC_738 1315-0003 72.4 µM 0.159768154829227 0.495793697976578 no 1653 0.436531855279023 2114 6251474 SGTC_2565 isoliquiritigenin 100 µM 0.159231345703714 0.495984324561156 no 1654 0.436743304304528 1845 638278 Binds to benzodiazepine receptor 65X better than valium. SGTC_3133 9127736 49.47 µM 0.158787853328477 0.496141814076679 no 1655 0.436918009514972 2159 27243420 SGTC_1564 D-Arginine 115 µM 0.158772553202559 0.49614724734763 no 1656 0.436924036922255 1935 71070 D-isomer of arginine; arginine decarboxylase inhibitor. SGTC_956 1185-0240 191 µM 0.1577258885444 0.496518933035069 no 1657 0.437336399862964 2027 1416193 SGTC_2102 5377816 72.7585 µM 0.157406069953666 0.496632505838248 no 1658 0.437462414979822 2132 1379702 SGTC_2702 st077768 96.8 µM 0.157170379023388 0.496716203710865 no 1659 0.437555286125402 1998 6484119 SGTC_2210 7115885 190.385 µM 0.157001664817273 0.496776117094413 no 1660 0.437621768020194 2042 2927039 SGTC_3063 1327-0034 4 µM 0.156703366088763 0.496882048399326 no 1661 0.437739317051757 2103 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_2440 5628896 157.78 µM 0.156438317912934 0.4969761720128 no 1662 0.437843767821211 2022 5522048 SGTC_2873 9040596 71.43 µM 0.156393446523554 0.496992106707505 no 1663 0.437861451266132 1954 6463863 SGTC_1772 st048439 82.2 µM 0.155025815089088 0.497477781156238 no 1664 0.438400482916015 1999 2927068 YDL195W SEC31 SGTC_2757 clomiphene 4.22 µM 0.154902871805894 0.497521441074305 no 1665 0.43844894480181 2149 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined. SGTC_226 1,3-diallylurea 8.28947 mM 0.154582797423972 0.49763510680606 no 1666 0.438575116315676 2084 74537 YKL182W FAS1 SGTC_2569 tetrandrine 100 µM 0.154516237581833 0.497658743752361 no 1667 0.438601354614085 1933 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_2506 ethyl hematommate 54.16 µM 0.154435026779165 0.497687583606249 no 1668 0.438633368776557 1940 3940691 An allergen. SGTC_2755 lomerizine 42.69 µM 0.154136497288154 0.497793598507719 no 1669 0.438751055727414 2022 3949 A calcium channel blocker. SGTC_1896 st058441 89 µM 0.15385556621937 0.497893363934575 no 1670 0.438861809935793 1982 688759 SGTC_2456 5770359 74.46 µM 0.153311580797404 0.498086546702601 no 1671 0.439076284241949 2115 3118787 SGTC_624 k048-0052 28 µM 0.152474736019419 0.498383731980018 no 1672 0.439406257588182 2029 6835531 SGTC_1151 3909-8316 15.3 µM 0.152033190961868 0.498540536449765 no 1673 0.439580378663885 2043 800431 SGTC_1947 st076332 61.6 µM 0.152024602955307 0.498543586283103 no 1674 0.439583765417132 2142 24208416 SGTC_359 0081-0058 15.9 µM 0.151659265941529 0.498673327411452 no 1675 0.439727843259833 2105 3494159 SGTC_2772 vinpocetine 57.06 µM 0.150673983324229 0.499023228776776 no 1676 0.440116448598169 2114 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor. SGTC_1666 st014829 29 µM 0.149213379722146 0.49954193119711 no 1677 0.440692631346301 2059 3858230 SGTC_2798 7813637 45.45 µM 0.148154154266055 0.499918093208412 no 1678 0.441110556019242 2071 956368 SGTC_975 1335-0046 28.5 µM 0.147692875702043 0.499918093208412 no 1679 0.441292577170461 1979 16486740 SGTC_2822 7994718 71.43 µM 0.146512720614646 0.499498985559528 no 1680 0.441758324339988 2145 1018011 SGTC_1831 st055328 12 µM 0.145618420317574 0.499181393665337 no 1681 0.442111312840617 2140 1103068 SGTC_3185 9108267 49.47 µM 0.145575094348428 0.499166007372477 no 1682 0.442128415166374 2010 4910486 SGTC_474 dl-dihydrosphingosine 5 µM 0.144639383369792 0.498833709938464 no 1683 0.442497800373389 2121 3058739 A sphingolipid protein kinase C inhibitor. SGTC_1520 flindersine 88 µM 0.143595642838823 0.498463049120092 no 1684 0.442909890754761 2145 68230 Flindersine is a natural alkaloid of the quinoline subtype. SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM 0.142051945498238 0.497914842486181 no 1685 0.443519487545529 2018 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_3275 9138069 49.47 µM 0.14167721258629 0.49778176574446 no 1686 0.443667487537435 2066 17617007 SGTC_1327 1436-0082 2.18 µM 0.137562169093216 0.496320433517291 no 1687 0.445293227948225 2044 15992205 SGTC_1794 st048918 76.9 µM 0.137500634693881 0.496298581777389 no 1688 0.445317545548532 2162 672303 SGTC_2486 5283202 22.39 µM 0.137406105154113 0.496265013015757 no 1689 0.445354902803211 2007 1377751 SGTC_2969 9091408 28.7 µM 0.13707868183344 0.496148740621301 no 1690 0.445484301410276 1922 4286311 SGTC_2374 9071832 200 µM 0.13638126227905 0.495901078725332 no 1691 0.445759942901664 2155 17381698 SGTC_1524 corynanthine 62.1 µM 0.135336638025777 0.495530123337305 no 1692 0.446172859292303 2078 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist. SGTC_43 0570-0105 72.5 µM 0.134321437711531 0.495169620352781 no 1693 0.44657420100502 2101 1114046 YDL195W SEC31 SGTC_1024 4507-0395 26 µM 0.133558137191712 0.494898570895398 no 1694 0.446875994601831 2050 4201836 SGTC_1041 0206-0046 107 µM 0.133500453172395 0.494878087285253 no 1695 0.446898802949708 2062 50494 SGTC_722 3534-0461 190 µM 0.13317074934936 0.494761009633417 no 1696 0.447029171705319 2047 658262 SGTC_2063 5246145 200 µM 0.132873123843254 0.494655323362081 no 1697 0.447146861234767 2118 711240 SGTC_421 streptovitacin 30 mM 0.131425619243176 0.494141322618617 no 1698 0.447719311603903 2041 91467 include heat shock SGTC_1717 st033143 58.0435 µM 0.130134659565303 0.493682918276365 no 1699 0.448229944451047 2159 674616 SGTC_1729 st035615 45.989 µM 0.129909482051648 0.493602961271651 no 1700 0.448319021136763 2023 17385451 SGTC_426 0988-0037 14.6 µM 0.127917327774448 0.492895590082054 no 1701 0.449107199059572 2228 5383008 SGTC_2412 st077135 33.4 µM 0.127750470489871 0.492836343627724 no 1702 0.449173223803281 2132 13258915 SGTC_2192 5915882 198.485 µM 0.126738204066443 0.492476918964463 no 1703 0.449573803581636 2165 2876149 SGTC_1543 azetidyl-2-carboxylic acid 198 µM 0.126041599691858 0.492229579713208 no 1704 0.44984949767153 2163 16486 A toxic proline analog. SGTC_1213 1315-0166 115 µM 0.12594613395463 0.49219568348148 no 1705 0.449887281895107 1954 768401 SGTC_2996 9066192 71.4286 µM 0.125512851357835 0.492041842116343 no 1706 0.450058775790405 2051 6472854 SGTC_2242 6630449 61.2675 µM 0.124326471283179 0.491620612006 no 1707 0.450528394422412 2107 691249 YDR170C SEC7 SGTC_212 3807-4682 38.772 µM 0.123098657022639 0.491184680328463 no 1708 0.451014487366849 2153 3125501 YBL034C STU1 SGTC_786 4544-0069 423 µM 0.123077456899054 0.491177153380748 no 1709 0.451022881165212 2123 748821 YLR208W SEC13 SGTC_1402 3909-7673 35.9 µM 0.120887990489912 0.490399816869048 no 1710 0.451889877302854 2173 5328014 SGTC_1629 st005085 44.9 µM 0.120801180709267 0.490368997118128 no 1711 0.45192425744227 2078 24207091 SGTC_58 0957-0393 9 µM 0.120531961223948 0.490273417500221 no 1712 0.452030881399995 2135 6997992 SGTC_2522 biochanin a 4.94 µM 0.120474050616377 0.490252857865998 no 1713 0.452053817258335 2164 5280373 A possible chelator. SGTC_2441 5730946 39.09 µM 0.119801532992322 0.490014100127446 no 1714 0.452320183769419 2130 1774275 SGTC_1120 ficusin 1.78878 µM 0.119731604096719 0.489989274119552 no 1715 0.452347881996305 2116 6199 A DNA cross-linker. SGTC_2557 derrustone 83.84 µM 0.11966116797917 0.489964268078008 no 1716 0.452375781363828 2011 629853 An antioxidant. SGTC_1351 1496-0003 46.5 µM 0.118914165804629 0.489699071816291 no 1717 0.452671679353755 2181 3891978 SGTC_2141 5621638 7.665 µM 0.11788740247414 0.489334563870927 no 1718 0.453078437505303 2181 2856238 SGTC_2676 harmalol 100 µM 0.117320643423615 0.489133364360556 no 1719 0.453302983454319 2171 5459187 A monoamine oxidase inhibitor SGTC_211 3455-0679 143.504 µM 0.115394921721004 0.488449753960808 no 1720 0.454066051977246 2087 748649 SGTC_2173 5763948 167 µM 0.112525955189178 0.487431365377875 no 1721 0.455203195582864 2215 2867177 SGTC_532 1548-0774 215 µM 0.111592526742462 0.487100046383873 no 1722 0.45557324890299 2213 5932993 SGTC_2387 9077560 195.08 µM 0.109061057111986 0.48620155059659 no 1723 0.456577031256329 2062 5303272 SGTC_2817 7995342 71.43 µM 0.108730202134506 0.486084125151013 no 1724 0.456708243012582 2119 18879975 SGTC_2808 7946468 45.46 µM 0.108259971021415 0.485917235081235 no 1725 0.456894737218215 2157 2970879 SGTC_729 4092-0585 94.1 µM 0.10792429483625 0.485798101506883 no 1726 0.457027872593281 2121 2169061 SGTC_2106 5357045 167.29 µM 0.107667805764627 0.485707072787349 no 1727 0.457129604148033 2181 668842 SGTC_2147 5545932 89.7195 µM 0.107662744351737 0.485705276484631 no 1728 0.457131611690323 2110 797404 SGTC_2422 chlorphenesin carbamate 384.24 µM 0.106121128570072 0.48515816849555 no 1729 0.457743123813419 2120 2724 A muscle relaxant with antifungal properties. SGTC_1685 st024049 53.0905 µM 0.10557442912145 0.484964155579703 no 1730 0.45796000697349 2140 1941139 SGTC_1377 2944-0135 198 µM 0.105353611292514 0.484885792668112 no 1731 0.458047611983933 2148 1894137 SGTC_3134 9127454 49.47 µM 0.10288070824519 0.484008259705819 no 1732 0.459028824517043 2241 24262820 SGTC_345 1362-0200 395 µM 0.102674489500343 0.483935084479964 no 1733 0.459110660523315 2087 1419823 SGTC_1326 1431-2094 10.8 µM 0.101905337195828 0.483662161155843 no 1734 0.459415906775297 2194 616278 SGTC_782 0083-0095 30.5 µM 0.101627779666356 0.483563675481924 no 1735 0.459526064309735 2258 3591729 An indicator and reagent. SGTC_422 cantharidin 155 µM 0.100652784469781 0.483217726150325 no 1736 0.459913046740578 2209 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_1705 st027868 56.3335 µM 0.100627763302873 0.483208848265631 no 1737 0.459922978318573 2222 292948 SGTC_954 1189-0853 2.85 µM 0.100543225896818 0.483178853189679 no 1738 0.459956533686796 2242 2828194 SGTC_2871 9038510 12.99 µM 0.100471986709392 0.483153576585046 no 1739 0.459984810824674 2243 4945164 SGTC_20 0481-0013 4.944 µM 0.100322751254078 0.483100626093989 no 1740 0.46004404786016 2157 182045 SGTC_788 1182-0090 188 µM 0.100245305949449 0.48307314770838 no 1741 0.460074789096724 2210 5715185 SGTC_2121 5257820 149.641 µM 0.0965897800953005 0.481776223520304 no 1742 0.461526086423313 2253 791256 SGTC_628 1636-0253 16 µM 0.0946788964549714 0.481098347359783 no 1743 0.462284940427228 2216 4456143 SGTC_3032 9089427 49.47 µM 0.0932437091089129 0.480589257847493 no 1744 0.462854975387601 2156 17173707 SGTC_1477 0139-0234 16 µM 0.0927350096151873 0.480408819569949 no 1745 0.463057041594823 2237 620880 SGTC_1369 1866-0067 208 µM 0.0919059893559319 0.480114770518305 no 1746 0.463386366393605 2222 3531355 SGTC_201 4262-0159 12.803 µM 0.0914750033057798 0.479961906336436 no 1747 0.463557583710538 2243 1341029 SGTC_3229 9132204 49.47 µM 0.090223875112406 0.479518167013996 no 1748 0.464054656050997 2160 17682924 SGTC_118 0083-0097 135.343 µM 0.0876456104156887 0.478603811062562 no 1749 0.46507917488511 2254 5207356 SGTC_1558 st069300 45.6 µM 0.0867510386307209 0.478286586136437 no 1750 0.465434703170452 2257 24208000 SGTC_1156 4092-0367 4.88 µM 0.0850511995829086 0.477683842711543 no 1751 0.466110343375948 2114 1357585 SGTC_415 dibenzyl ketone 100 µM 0.0838395190115262 0.477254225761534 no 1752 0.466592013492205 2231 7593 SGTC_1008 4106-0037 6 µM 0.0838058201441442 0.477242277769645 no 1753 0.466605410248026 2255 2905394 SGTC_1491 4138-0063 26.5 µM 0.0834105308216927 0.477102128784872 no 1754 0.466762557653858 2271 23883227 SGTC_837 0091-0265 12.5 µM 0.0819528763386612 0.476585345112943 no 1755 0.467342093287499 2145 759367 SGTC_1597 7-benzyloxygramine 47.5 µM 0.0815889238116479 0.476456318776574 no 1756 0.467486804723081 2210 260807 SGTC_3326 9140064 16.379 µM 0.0815444652355516 0.47644055774926 no 1757 0.467504482225569 2244 1868434 SGTC_536 3852-0578 10.6 µM 0.0811774093002365 0.476310434015719 no 1758 0.467650432489974 2242 2869208 SGTC_328 k915-0120 63.5 µM 0.0802138104494928 0.4759688439673 no 1759 0.468033603202966 2260 6624543 SGTC_1720 st037298 9.481 µM 0.0774333837917076 0.474983299170816 no 1760 0.46913939203663 2192 597396 SGTC_687 k029-0044 34.9 µM 0.0750633711553681 0.474143349552571 no 1761 0.470082145577933 2269 5829338 SGTC_2950 9072895 21.46 µM 0.0742872568995194 0.473868313845793 no 1762 0.470390908267478 2194 17332245 SGTC_704 1310-0270 142 µM 0.0726705830935289 0.473295444758556 no 1763 0.471034128963482 2208 5718033 SGTC_188 3229-0966 278.469 µM 0.0721810748356605 0.473121998126172 no 1764 0.471228902988077 2278 5722370 SGTC_1395 3486-0190 4.35 µM 0.0718870953258406 0.473017835311126 no 1765 0.471345879958206 2280 6748079 SGTC_2978 9011784 42.97 µM 0.0718045906549853 0.472988602588771 no 1766 0.471378709719553 2276 2994934 SGTC_2948 9070189 9.45 µM 0.0698759287654691 0.47230528866567 no 1767 0.472146206175147 2286 6473636 YDL196W YDL196W SGTC_1046 2001-0062 216 µM 0.0692242712299391 0.472074428433274 no 1768 0.472405551898984 2234 739778 SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM 0.0682789593710588 0.471739553098946 no 1769 0.472781786512111 2220 6708760 SGTC_1652 st011932 78 µM 0.0678363803176855 0.47158277697274 no 1770 0.472957941573124 2280 1551076 SGTC_2008 4012253 172 µM 0.0669070693674565 0.471253598683069 no 1771 0.473327842555315 2257 603940 SGTC_187 1488-2104 32.728 µM 0.0668211354307634 0.47122316035922 no 1772 0.47336204868592 2250 2852859 SGTC_395 anisomycin 6.25 µM 0.0665154726172965 0.471114894092315 no 1773 0.473483719811052 2176 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_67 0335-0847 266 µM 0.0663742791335686 0.471064883850491 no 1774 0.473539923656559 2265 4552207 YOR254C SEC63 SGTC_3141 9094609 49.47 µM 0.0659660412149261 0.470920289966494 no 1775 0.473702430863828 2177 25236309 YDL196W YDL196W SGTC_214 4373-3496 70 µM 0.0655716499554422 0.470780604074441 no 1776 0.473859430290057 2225 3779166 SGTC_1706 st031321 9.9705 µM 0.0650045855397698 0.470579766935575 no 1777 0.474085174623162 2291 6103185 SGTC_3023 9089636 49.47 µM 0.0642780946039048 0.470322476665778 no 1778 0.474374397676119 2313 17249241 SGTC_2308 7584454 197.62 µM 0.0639490965646072 0.470205964492165 no 1779 0.474505379423026 2265 893577 SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM 0.0613776353279847 0.469295389552458 no 1780 0.475529231597709 2253 521171 SGTC_748 act1.228 77.9 µM 0.0594828607780857 0.468624537247388 no 1781 0.476283758210535 2265 4421505 YNR035C ARC35 SGTC_2248 tofa 1.1 µM 0.0589994077766157 0.468453383018313 no 1782 0.476476289908792 2217 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_3305 9127027 53.8275 µM 0.05822082636345 0.468177758356786 no 1783 0.476786365909648 2224 41905295 SGTC_1134 3477-0009 42.5 µM 0.057388526226119 0.467883133666643 no 1784 0.477117851342484 2308 3973534 SGTC_500 h-89 112 µM 0.0570298441189845 0.46775616973471 no 1785 0.477260710826339 2300 449241 Protein kinase A inhibitor; also known to inhibit several other kinases. SGTC_1365 1672-3266 55.4 µM 0.0565567754450557 0.467588721016477 no 1786 0.477449133797713 2303 6415873 SGTC_3057 9095946 49.47 µM 0.0556805401277442 0.467278581470744 no 1787 0.477798151088564 2315 24540043 SGTC_2273 7815444 169.05 µM 0.0555545471205983 0.467233988442087 no 1788 0.477848337345205 2310 2824616 SGTC_3065 9113888 49.47 µM 0.0548213914868019 0.466974508962032 no 1789 0.478140379042857 2279 16648368 SGTC_1080 nisoldipine 24.4 µM 0.0544957390625002 0.466859258089799 no 1790 0.478270101641309 2313 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class. SGTC_766 1391-0721 126 µM 0.054042589775814 0.46669888973269 no 1791 0.478450616033467 2306 1020919 YIL115C NUP159 SGTC_1928 4'-methoxychalcone 40.3 µM 0.0539400989543568 0.46666261924554 no 1792 0.478491444403411 2325 641818 SGTC_1631 benzylvanillin 81.9 µM 0.0534992759518011 0.466506619508572 no 1793 0.478667053765817 2254 75506 SGTC_817 1391-0715 46 µM 0.0531693860614379 0.466389880471428 no 1794 0.478798473741976 2259 1353946 SGTC_372 0155-0182 15.9 µM 0.0523782347805573 0.466109925406986 no 1795 0.479113658217953 2237 771486 SGTC_1576 erythromycin ethylsuccinate 23.2 µM 0.0522462005532855 0.466063205692713 no 1796 0.479166260229876 2306 3256 An antibiotic and ribosome inhibitor. SGTC_2002 4023503 131 µM 0.0500232231993987 0.465276685937677 no 1797 0.480051941024534 2333 4736863 YCR052W RSC6 SGTC_2328 6201408 200 µM 0.0492104010481307 0.464989132057582 no 1798 0.480375811236376 2267 2890418 SGTC_332 4112-0506 40.9 µM 0.0489460784735647 0.464895626011087 no 1799 0.480481133766516 2311 2790355 SGTC_2583 asiatic acid 100 µM 0.0472781270980132 0.464305620917381 no 1800 0.481145780316167 2299 5320556 A kinase inhibitor; arrests cells at G2/M. SGTC_2778 tioconazole 65.09 nM 0.0468209787509711 0.464143927301339 no 1801 0.481327954371255 2302 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_249 wiskostatin 11.211 µM 0.0466708980623531 0.464090844971008 no 1802 0.48138776252178 2307 2775510 A n-wasp and actin depolymerizer. SGTC_585 0kpi-0023 191 µM 0.0461383573265511 0.463902494768034 no 1803 0.481599986910883 2323 64601 SGTC_284 0988-0104 32.6 µM 0.0447856819683245 0.463424113979429 no 1804 0.482139068887906 2303 4666532 SGTC_14 0354-0009 295 µM 0.0447493621197308 0.463411269998992 no 1805 0.482153543898948 2331 1713507 SGTC_1681 tripelennamine 100 µM 0.0443117024420443 0.463256501091614 no 1806 0.482327971819131 2341 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist. SGTC_28 pentachloropyridine N-oxide 1.606 µM 0.0440521884075309 0.463164732174419 no 1807 0.482431401940196 2316 140250 A respiratory chain inhibitor. SGTC_849 0386-0493 241 µM 0.0432625488166083 0.462885513224695 no 1808 0.482746122484866 2240 726119 SGTC_361 000s-0510 1.45 µM 0.0428375109299773 0.462735226102647 no 1809 0.482915531011744 2277 660 SGTC_985 1493-0307 8.71 µM 0.0421929757874127 0.46250733814698 no 1810 0.483172431042623 2332 3278274 SGTC_3155 9099265 49.47 µM 0.0410441387304253 0.462101174988535 no 1811 0.483630353935897 2299 25236499 SGTC_1696 st025591 34.7925 µM 0.0395173693022444 0.461561457758893 no 1812 0.484238952816076 2347 2787147 SGTC_639 0833-0042 114 µM 0.0369463180478084 0.460652744472203 no 1813 0.485263904238306 2300 5978911 YPR085C | YHR062C ASA1 | RPP1 SGTC_1423 4048-0112 5.59 µM 0.0366683882957178 0.460554525100089 no 1814 0.485374707084804 2344 X1423 SGTC_2857 9024691 58.44 µM 0.0350898579990091 0.459996724011634 no 1815 0.486004044288862 2310 16478292 SGTC_663 1486-0733 13.9 µM 0.0328958760845452 0.459221573387042 no 1816 0.486878810712737 2312 722445 YPR165W RHO1 SGTC_2322 7413319 38.22 µM 0.0324336129389881 0.45905827194621 no 1817 0.487063128666002 2313 1840400 SGTC_2354 9060492 162 µM 0.032372851148282 0.459036807438663 no 1818 0.487087356390819 2330 6471895 SGTC_357 1325-0123 420 µM 0.0320576280437062 0.458925454694173 no 1819 0.487213046975343 2341 1098503 SGTC_3248 9135562 49.47 µM 0.0311980923946876 0.458621839627572 no 1820 0.487555780611907 2334 17650701 SGTC_3280 9140961 49.47 µM 0.0281614635085413 0.457549401107455 no 1821 0.488766686345065 2341 4901226 SGTC_2303 7774051 200 µM 0.0253235959368906 0.456547437797281 no 1822 0.489898426564274 2347 2953184 SGTC_127 0180-0333 59.125 µM 0.0251192294464943 0.456475292893272 no 1823 0.489979931070416 2364 771601 SGTC_1247 0448-0043 5.84 µM 0.0250831233830941 0.45646254697779 no 1824 0.489994330768568 2330 3089013 YGL099W LSG1 SGTC_593 1203-0218 61.7 µM 0.025073966159348 0.456459314364433 no 1825 0.489997982823661 2370 3666956 SGTC_1081 sertraline 6 µM 0.0246967238856104 0.456326145678305 no 1826 0.490148434122734 2364 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1 SGTC_1418 3966-3099 2.4 µM 0.0245867944063377 0.456287340864005 no 1827 0.490192276326985 2356 740335 SGTC_727 3032-0951 202 µM 0.0237772286281768 0.456001579158481 no 1828 0.490515151918115 2337 3652836 SGTC_621 3584-0052 32.1 µM 0.0225690712932866 0.455575164393435 no 1829 0.490997007536712 2359 2273927 SGTC_2519 cryptotanshinone 88.04 µM 0.0223398721222171 0.455494275134107 no 1830 0.49108842172791 2356 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE) SGTC_1621 st003705 32.4 µM 0.021742087441403 0.455283312903145 no 1831 0.491326845387402 2360 24207032 SGTC_2101 5377231 179.231 µM 0.0206611068673408 0.454901859651203 no 1832 0.491757997307752 2343 2844213 SGTC_1781 st038725 66.3 µM 0.0205110618457408 0.454848915482835 no 1833 0.491817843928326 2352 4270275 YIL048W NEO1 SGTC_2351 9026858 72.31 µM 0.0198689640240324 0.454622356989471 no 1834 0.492073951688389 2370 1409300 SGTC_670 4204-0025 119 µM 0.0197436526252609 0.454578143698506 no 1835 0.492123933898824 2355 719039 SGTC_2644 guaiazulene 100 µM 0.0187289693729086 0.454220156451857 no 1836 0.492528659043748 2359 3515 A coloring agent. SGTC_2165 5727197 32.143 µM 0.0184477457459014 0.454120945386441 no 1837 0.49264083165743 2325 1361712 SGTC_1012 4112-3522 18 µM 0.0184268557715497 0.454113575861571 no 1838 0.492649164135068 2373 3112398 SGTC_1801 st050089 28.441 µM 0.0180319250744416 0.453974255947021 no 1839 0.492806692510594 2361 5008493 YIL048W | YNL267W NEO1 | PIK1 SGTC_587 k089-0003 57 µM 0.0176393945508973 0.453835788354602 no 1840 0.492963264626161 2368 9659696 SGTC_3292 9120825 59.784 µM 0.0164352135207556 0.453411041061786 no 1841 0.493443593605785 2378 24824900 SGTC_349 k015-0014 24 µM 0.0156469680227113 0.45313303433446 no 1842 0.493758017598294 2369 2196908 SGTC_3356 9151811 4.48 µM 0.0142615492876583 0.452644466002148 no 1843 0.494310657866689 2375 1859254 YPR165W RHO1 SGTC_1035 k081-0041 55.2 µM 0.0134534575549956 0.452359525264549 no 1844 0.49463300886444 2378 731709 SGTC_644 1498-1197 63.3 µM 0.0123714545399636 0.451978039278989 no 1845 0.495064629609714 2361 6741615 SGTC_977 1348-1378 135 µM 0.0122210664232242 0.451925019860678 no 1846 0.495124621252414 2384 X977 SGTC_2094 5332512 191.667 µM 0.00972392711078256 0.451044777968236 no 1847 0.496120775477253 2387 755774 SGTC_1769 st044406 64.4 µM 0.00898231530706115 0.450783405883186 no 1848 0.496416622833847 2384 670903 SGTC_2563 tomatine 8.54 µM 0.00884507845558999 0.450735040756055 no 1849 0.496471370241292 2394 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties. SGTC_1764 st044502 93.5 µM 0.00792056973681152 0.450409243709974 no 1850 0.496840182885897 2381 8407 SGTC_3027 9089541 49.47 µM 0.00625343302985423 0.449821829022555 no 1851 0.497505257426404 2384 9943819 SGTC_3113 9123498 49.47 µM 0.0059653004583259 0.449720316777585 no 1852 0.497620203545985 2397 8897275 SGTC_3045 9092950 49.47 µM 0.00434440362328376 0.449149318662698 no 1853 0.498266839163445 2395 44120432 SGTC_1279 0874-0590 65.2 µM 0.00277222235296429 0.448595582305008 no 1854 0.498894044709313 2395 3523074 SGTC_2400 5203494 178.7 µM 0.00236731319292965 0.448452985834996 no 1855 0.499055579558504 2404 6777674 SGTC_3340 9146634 11.102 µM 0.000977423902306944 0.447963560633709 no 1856 0.499610064341583 2402 4907387 SGTC_380 3970-0968 6 µM 0.000822721416627888 0.447909089744494 no 1857 0.499671781678942 2405 2891601 SGTC_113 0099-0221 2.5 µM -3.27119878636628e-05 0.447607908606549 no 1858 0.499986949804968 2406 89219 SGTC_2598 perillyl alcohol 100 µM -0.000275049543874588 0.447522591841789 no 1859 0.499890271109127 2407 10819 An apoptosis inducer. SGTC_495 decylubiquinone 155 µM -0.001032945840602 0.44725578442151 no 1860 0.4995879143041 2409 2971 A Co-enzyme Q analog. A free radical scavenger. SGTC_32 0928-0142 34.1 µM -0.00235282127487512 0.4467911966844 no 1861 0.499061360981239 2415 2244242 SGTC_3173 9105693 49.47 µM -0.00355718317262869 0.446367332668695 no 1862 0.498580892226099 2419 17096658 SGTC_1909 st060837 51.5 µM -0.00395828691028282 0.44622618150062 no 1863 0.498420876117158 2416 678937 SGTC_618 k072-0232 33.2 µM -0.00405464700413898 0.446192272734291 no 1864 0.498382434310121 2412 5872756 YGL099W LSG1 SGTC_2771 fluoxetine 41.05 µM -0.00544351898496128 0.445703577569829 no 1865 0.497828360847702 2421 3386 A selective serotonin reuptake inhibitor. SGTC_1523 st012844 44.7 µM -0.0065732737939536 0.445306117417527 no 1866 0.497377662047249 2439 4274103 SGTC_2786 7743617 45.45 µM -0.00733201620818774 0.445039214332593 no 1867 0.497074974941463 2435 583674 SGTC_298 1391-0729 10 µM -0.00744820630584386 0.444998344297894 no 1868 0.497028623064713 2423 3237558 SGTC_1091 telmisartan 47.6 µM -0.00796104477857466 0.444817959615298 no 1869 0.496824036189523 2434 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension. SGTC_1282 0886-0010 32.4 µM -0.00913213960027352 0.444406084183448 no 1870 0.496356854040277 2425 2836211 YNL267W PIK1 SGTC_2188 6126565 140.678 µM -0.00969561452964488 0.444207930747025 no 1871 0.4961320700305 2422 874518 SGTC_2860 9025725 38.96 µM -0.0104364762730436 0.443947418112504 no 1872 0.495836523937408 2435 40546248 SGTC_295 k015-0027 31 µM -0.0107795782211393 0.443826779789051 no 1873 0.495699653765729 2445 3887424 SGTC_1843 st055809 45.5 µM -0.0121041090513102 0.443361109481266 no 1874 0.495171277042059 2465 16413835 SGTC_557 1315-0110 16.2 µM -0.0123843221274881 0.443262603912995 no 1875 0.49505949657824 2434 6833801 SGTC_2111 5486399 200 µM -0.0125576913265289 0.443201659792118 no 1876 0.494990337652924 2425 689674 SGTC_1468 k284-1086 134 µM -0.0133601356215003 0.442919595710295 no 1877 0.49467023558363 2434 15996457 SGTC_3144 9087057 49.47 µM -0.0164694651880297 0.441826921799128 no 1878 0.493429931016752 2426 17249618 SGTC_3318 9139014 38.6185 µM -0.0211842950720525 0.440170893307085 no 1879 0.491549321094652 2443 16643984 SGTC_2892 9047358 58.44 µM -0.0219143235925813 0.439914572179719 no 1880 0.491258149472309 2456 6466771 SGTC_2269 7935389 174.42 µM -0.0219555220224231 0.439900107702776 no 1881 0.49124171763025 2433 97605 SGTC_1527 coumarin 137 µM -0.0235689540124922 0.439333706434168 no 1882 0.490598218189032 2533 323 A hepatotoxic, DNA x-linker. SGTC_161 4065-0411 162.148 µM -0.0236327879674608 0.439311299834196 no 1883 0.490572759216799 2466 1906281 YLR208W SEC13 SGTC_964 1287-0107 19.4 µM -0.023846014203661 0.43923645588977 no 1884 0.490487718222241 2460 51516812 YPR165W RHO1 SGTC_2424 5537928 59.2 µM -0.0240592405334598 0.439161614084643 no 1885 0.490402677622752 2450 5382802 SGTC_261 5-fluorouridine 15.376 µM -0.0254686524921387 0.438666969516238 no 1886 0.489840576030126 2469 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_3241 9133421 49.47 µM -0.0275592003389085 0.437933451400022 no 1887 0.48900686135395 2451 17018221 SGTC_1614 st002383 48.6 µM -0.0281107324199026 0.437739968777764 no 1888 0.488786917111925 2445 1947235 SGTC_1176 0848-0131 83.3 µM -0.0283448950399835 0.437657826835118 no 1889 0.488693536953007 2477 6769040 SGTC_664 1222-0054 14.9 µM -0.0289712489057912 0.437438121277061 no 1890 0.488443760507423 2472 6813991 SGTC_1102 cgs 12066b 26.1 µM -0.0303421227982194 0.436957328527426 no 1891 0.487897101444808 2503 6438352 A 5-HT1B full agonist. SGTC_772 k072-0172 35.3 µM -0.0313879712054104 0.4365905912496 no 1892 0.487480067006767 2473 5861980 SGTC_2781 5567276 71.43 µM -0.0317819260051029 0.436452461144228 no 1893 0.487322980156789 2498 2853274 SGTC_3233 9132340 49.47 µM -0.0319909053926523 0.436379191048061 no 1894 0.487239651816059 2469 17682950 SGTC_1544 7-methoxy-4-methylcoumarin 105 µM -0.0321247668714035 0.436332259128726 no 1895 0.487186276246722 2480 390807 SGTC_3052 9092717 49.47 µM -0.0321620063038062 0.436319203119442 no 1896 0.487171427535445 2518 25237534 SGTC_1428 4049-0204 61.7 µM -0.0324554534730981 0.436216324039931 no 1897 0.487054420138231 2471 X1428 SGTC_2770 toltrazuril 17.5 µM -0.0325305737992083 0.436189988442498 no 1898 0.487024467280263 2467 68591 Kills coccidiodes. SGTC_1610 st001799 48.1 µM -0.0337659782219493 0.435756922448604 no 1899 0.486531882956147 2470 621897 SGTC_1722 st034304 3.6505 µM -0.0349722771202715 0.435334133594242 no 1900 0.48605092349939 2470 4036148 YLR033W RSC58 SGTC_2218 6965428 192.983 µM -0.0349773554858118 0.435332353862622 no 1901 0.486048898763406 2470 675684 SGTC_107 0358-0022 2.6945 µM -0.0365432888902232 0.434783629472678 no 1902 0.485424581100403 2544 521106 YGL093W | YPR107C SPC105 | YTH1 SGTC_1211 1056-0033 32.3 µM -0.0368761380154794 0.434667010755675 no 1903 0.4852918829543 2490 6741922 SGTC_17 0960-0276 49.807 µM -0.0372496248366371 0.434536160776163 no 1904 0.485142985573138 2471 6821114 SGTC_2970 9090938 41.86 µM -0.0375292504245921 0.434438199489484 no 1905 0.485031509051442 2477 17217104 SGTC_1589 2',5'-dimethoxyflavone 47.2 µM -0.0376475351518819 0.434396761989141 no 1906 0.484984353597068 2471 688667 SGTC_1257 0669-0121 16 µM -0.0380452365224864 0.434257444551004 no 1907 0.484825807293887 2520 4307855 SGTC_916 4466-0038 42 nM -0.0390581106420242 0.433902664919033 no 1908 0.484422029165535 2470 5722064 YGL116W CDC20 SGTC_1813 st051246 8.6015 µM -0.0392047445608904 0.433851307830298 no 1909 0.484363575466905 2484 5291959 SGTC_2977 9011197 71.43 µM -0.0392792875184206 0.433825200320219 no 1910 0.4843338600182 2590 2704722 SGTC_864 0469-0573 172 µM -0.0398216282675928 0.433635262616239 no 1911 0.484117666520879 2479 689425 SGTC_1809 st050081 57.6 µM -0.0420435085201366 0.432857279750285 no 1912 0.483232006989313 2540 5036894 SGTC_2909 7941780 10.49 µM -0.0425529841024993 0.432678925385532 no 1913 0.483028937382294 2476 1243215 SGTC_840 0245-0196 390 µM -0.0429819150434273 0.43252877827104 no 1914 0.48285797511708 2577 3827528 SGTC_1055 3448-0672 86 µM -0.0439665859975141 0.432184131461955 no 1915 0.48246551930514 2563 748378 SGTC_2060 5238662 140 µM -0.0455298422848514 0.431637078837902 no 1916 0.481842494426099 2534 790130 SGTC_2645 abamectin 100 µM -0.0461384192717953 0.43142414618257 no 1917 0.481599962224595 2507 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels. SGTC_568 1193-0097 7.48 µM -0.047352931584423 0.430999264776154 no 1918 0.481115971030372 2493 3646150 SGTC_3103 9120822 49.47 µM -0.0485721924247115 0.43057280247039 no 1919 0.480630115514713 2502 17141819 SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM -0.049062156601423 0.430401449896126 no 1920 0.480434880862807 2497 803109 SGTC_2283 7944793 200 µM -0.0490962230101171 0.43038953651848 no 1921 0.480421306690396 2514 2970533 SGTC_1003 4049-0218 100 µM -0.0505502146212456 0.429881119721943 no 1922 0.479841967520964 2549 295161 SGTC_2585 alliin 100 µM -0.0506005365329903 0.429863525751166 no 1923 0.479821917641624 2531 87310 A garlic compound which reacts with lipids. SGTC_220 paclitaxel 373.376 µM -0.0510937309879859 0.429691098327431 no 1924 0.479625415708411 2511 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_2555 cholic acid 100 µM -0.0516498888021017 0.429496674155099 no 1925 0.479403833422416 2631 6708657 Influences liver metabolism. SGTC_81 0411-0046 9.971 µM -0.05197718445873 0.429382264643833 no 1926 0.479273436499471 2489 12925265 SGTC_1450 4112-4260 37.6 µM -0.0522289947806121 0.429294245832462 no 1927 0.479173114981171 2498 1633175 SGTC_2944 9067346 25.62 µM -0.0538436631925706 0.428729931743293 no 1928 0.478529860878436 2529 6473075 SGTC_1444 4112-3581 28 µM -0.0539102955966268 0.428706647356604 no 1929 0.478503316948105 2492 2877249 SGTC_2163 5671233 125 µM -0.0557385940076987 0.428067853983711 no 1930 0.477775026852847 2509 701023 SGTC_354 2783-3500 4.88 µM -0.056449211605714 0.42781962044109 no 1931 0.477491977115896 2520 6740761 SGTC_942 3253-1115 227 µM -0.0573562143861497 0.427502826971024 no 1932 0.477130720703843 2562 46497897 SGTC_2000 st075254 36.4 µM -0.0575810118655157 0.427424318032489 no 1933 0.477041187455235 2510 17234175 SGTC_1517 deoxycholic acid methyl ester 49.2 µM -0.0585399223202256 0.427089457614441 no 1934 0.476659281794527 2506 229346 A bile salt which induces apoptosis. SGTC_1173 0443-0020 122 µM -0.058822393750922 0.426990825978387 no 1935 0.476546785853693 2525 5331295 SGTC_68 0986-0284 82.829 µM -0.0611203573633886 0.426188607317194 no 1936 0.475631678313656 2742 423278 YIL048W NEO1 SGTC_851 0394-0702 453 µM -0.0611924383002187 0.426163448797504 no 1937 0.475602975905578 2517 762646 SGTC_1118 chelidonine 707.474 nM -0.0613789705502571 0.426098344556071 no 1938 0.475528699923522 2525 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor. SGTC_1889 st059080 5.18 µM -0.0620536308054667 0.425862888730134 no 1939 0.475260061524011 2503 176925 Isolated from Daphnopsis sellowiana. SGTC_91 0417-1751 58.384 µM -0.0631125178896218 0.425493391410014 no 1940 0.474838453168921 2503 6795624 SGTC_3015 9080845 49.47 µM -0.0640801698738374 0.425155787666332 no 1941 0.474453195768792 2587 5296973 SGTC_2799 7812892 81.82 µM -0.0642693091408116 0.425089805341153 no 1942 0.474377895336726 2562 20205235 SGTC_1791 st048313 56.1 µM -0.0649723098317109 0.424844577900277 no 1943 0.474098023605238 2522 1204976 SGTC_712 r015-0009 80.6 µM -0.0662046455283162 0.424414772975796 no 1944 0.473607449147294 2576 6813872 YLR060W FRS1 SGTC_1898 st060199 18.6 µM -0.0671722800485177 0.424077351526524 no 1945 0.473222276292651 2526 688866 SGTC_767 0929-0023 86 µM -0.0686224284460982 0.423571778113258 no 1946 0.472645082814594 2532 1204563 SGTC_3312 9133330 71.43 µM -0.0688720344910475 0.423484769216835 no 1947 0.472545739445087 2661 17617324 SGTC_1863 st057641 20.1 µM -0.0693197461430889 0.423328713048978 no 1948 0.472367554196982 2522 3921635 SGTC_2769 toremifene 3.73 µM -0.0696667268639989 0.423207776329529 no 1949 0.472229462763681 2621 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_1844 rapamycin 4 nM -0.0704502707225995 0.422934706453168 no 1950 0.471917640180402 2519 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2 SGTC_2942 9052777 62.25 µM -0.0706334537586628 0.422870871367891 no 1951 0.471844742323683 2552 6469503 SGTC_1338 1486-1223 76 µM -0.0717400523533682 0.422485290273483 no 1952 0.471404390547125 2601 3444526 SGTC_852 0418-0143 439 µM -0.0726630615776717 0.422163735496921 no 1953 0.471037121702201 2541 5369229 SGTC_708 3448-5400 146 µM -0.0734493281715807 0.421889859555602 no 1954 0.470724282680588 2531 3462195 SGTC_863 0466-0191 129 µM -0.0738592681250007 0.421747082386638 no 1955 0.470561183305866 2523 765160 YPR165W RHO1 SGTC_3111 9122088 49.47 µM -0.0763266162936827 0.420887952522177 no 1956 0.469579625432141 2628 16876704 SGTC_1739 st037196 92.5 µM -0.0778889100518017 0.42034415679368 no 1957 0.468958210553617 2565 612214 SGTC_1481 3346-2004 36 µM -0.0783135640347962 0.420196371499599 no 1958 0.468789314030631 2545 2770522 SGTC_1033 k072-0102 21.3 µM -0.0785662477366398 0.420108439512469 no 1959 0.468688817463302 2534 5965931 SGTC_1996 st072960 66.8 µM -0.0786566129741274 0.420076994071816 no 1960 0.468652878169194 2518 1719405 SGTC_1262 0737-0114 49.6 µM -0.0792008408429928 0.41988762357859 no 1961 0.46843643789961 2551 765919 SGTC_548 1436-0017 110 µM -0.079912291724888 0.419640093847946 no 1962 0.468153506856853 2557 9677137 SGTC_2568 diosmetin 100 µM -0.0801509228702798 0.419557075831689 no 1963 0.468058611197024 2539 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.  SGTC_409 arachidonic acid 100 µM -0.0835702942952675 0.418367896684013 no 1964 0.466699043004834 2550 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes. SGTC_2076 5212012 200 µM -0.0837571661921984 0.418302928307531 no 1965 0.466624752362872 2532 604802 SGTC_810 3825-7150 143 µM -0.0840075386372574 0.418215886656946 no 1966 0.466525218996422 2562 22330411 YGL099W LSG1 SGTC_279 1273-0055 2.93 µM -0.0840475372137702 0.418201981575456 no 1967 0.466509318107425 2569 2847562 SGTC_2674 ligustilide 100 µM -0.0843486422036115 0.418097308897608 no 1968 0.466389619639729 2624 5319022 A signalling regulator. SGTC_2874 9043904 71.43 µM -0.0844166041349381 0.418073684195087 no 1969 0.466362603107915 2634 4463428 SGTC_527 4476-4215 268 µM -0.0846146612533273 0.418004837918785 no 1970 0.466283871438215 2579 4418754 SGTC_1251 0490-5699 265 µM -0.0846457905886731 0.417994017335325 no 1971 0.466271497024107 2565 3883818 SGTC_3200 9114385 49.47 µM -0.0848558972786892 0.417920985694893 no 1972 0.46618797707109 2622 17018030 YLR208W SEC13 SGTC_2657 nystatin 74.44 µM -0.0861441421981708 0.417473262591163 no 1973 0.465675916810321 2608 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_387 norethindrone acetate 66.7 µM -0.0867623806148597 0.417258434859889 no 1974 0.465430195369889 2609 541197 SGTC_517 1365-0151 113 µM -0.0878833263906906 0.416868987578804 no 1975 0.464984704467703 2710 768657 SGTC_2174 5790901 200 µM -0.0882367028937848 0.41674623178951 no 1976 0.464844273189207 2621 786020 SGTC_3258 9138477 49.47 µM -0.0889331583698193 0.416504321138592 no 1977 0.464567515690268 2571 4970355 SGTC_1162 k048-0130 20.1 µM -0.0892200557262575 0.416404677833508 no 1978 0.464453513387131 2560 6797406 SGTC_2914 7968218 45.32 µM -0.0894750756983033 0.416316110481704 no 1979 0.464352180416422 2633 2977111 SGTC_2393 9031399 185.94 µM -0.0899868992563977 0.416138369161819 no 1980 0.464148812734146 2639 1526623 YDL150W RPC53 SGTC_405 ebelactone b 50 µM -0.0903649148490727 0.416007106434813 no 1981 0.463998618243428 2594 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).  SGTC_1299 1079-1439 3.74 µM -0.0915257122245809 0.415604087953389 no 1982 0.463537438287515 2586 323161 SGTC_1297 1068-0111 14.1 µM -0.0919999036975157 0.415439478420214 no 1983 0.463349058053337 2559 767057 SGTC_3117 9124945 49.47 µM -0.0938058504131237 0.414812703124466 no 1984 0.462631692111709 2550 17592065 SGTC_1325 1431-0015 227 µM -0.0960915419502104 0.414019737689178 no 1985 0.461723934384073 2573 1103340 SGTC_735 3076-0345 636 µM -0.0963530393486292 0.413929039764329 no 1986 0.461620093846058 2644 2888990 SGTC_2206 7254556 146.969 µM -0.0986330546127676 0.413138432838102 no 1987 0.460714812095465 2629 4398905 SGTC_1590 st077108 57.8 µM -0.0992072703281581 0.412939375991846 no 1988 0.460486851225691 2556 5489485 SGTC_3235 9132602 49.47 µM -0.0999090542563238 0.412696126919358 no 1989 0.460208264031718 2670 4912240 SGTC_1678 st019265 80.2 µM -0.100928964446061 0.412342670190877 no 1990 0.4598034251001 2610 5367020 SGTC_1912 st060209 90.8 µM -0.101056432759444 0.412298500181749 no 1991 0.459752831276037 2644 688787 SGTC_2458 5808907 16.39 µM -0.10123069913545 0.41223811561959 no 1992 0.459683663749675 2588 2731747 SGTC_1972 st070201 17.4 µM -0.101835789981566 0.412028463395983 no 1993 0.459443508507302 2642 2829099 SGTC_147 4466-0538 29.23 µM -0.103269455144223 0.411531826582916 no 1994 0.458874558621033 2764 6742687 YHR072W ERG7 SGTC_440 fluspirilene 35.1 µM -0.103297337351862 0.411522169292826 no 1995 0.45886349440076 2844 3396 An atypical antipsychotic. SGTC_3218 9131285 49.47 µM -0.10420877319295 0.41120651364007 no 1996 0.458501835940081 2622 17156417 SGTC_2526 patulin 37.61 µM -0.105126077242314 0.410888883695174 no 1997 0.458137883651356 2690 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.  SGTC_1575 cyproterone acetate 48 µM -0.106996357886649 0.410241452860778 no 1998 0.457395934577256 2626 9880 An androgen receptor antagonist and liver toxin. SGTC_747 3448-8087 38.7 µM -0.108238763890847 0.409811507055405 no 1999 0.456903148214882 2641 5168703 SGTC_2277 7947813 106.88 µM -0.108554821843221 0.409702149628144 no 2000 0.456777797927067 2837 1246798 SGTC_1574 spiramycin 23.7 µM -0.109543527896771 0.409360098424159 no 2001 0.456385699602271 2578 6419898 An antibiotic and protein synthesis inhibitor. SGTC_181 1447-1644 8.07 µM -0.110177969789809 0.409140644219889 no 2002 0.456134116726299 2612 534600 SGTC_1680 diphenhydramine 100 µM -0.111117283316704 0.408815786860888 no 2003 0.455761671754652 2678 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1 SGTC_2327 6189656 200 µM -0.11133087901201 0.408741924482675 no 2004 0.455676984846654 2694 5349088 SGTC_2207 7258803 200 µM -0.111699083614521 0.408614605240624 no 2005 0.455531002976869 2617 3666799 SGTC_1396 3511-0007 98.6 µM -0.111744468206446 0.408598912644497 no 2006 0.455513009788692 2696 X1396 SGTC_1090 efavirenz 20.7 µM -0.11176582810301 0.408591527099884 no 2007 0.455504541469625 2637 64139 A non-nucleoside reverse transcriptase inhibitor. SGTC_1954 st077032 68.9 µM -0.1128745642086 0.408208207520258 no 2008 0.455065001127031 2693 698907 SGTC_1412 3909-8563 178 µM -0.113088086072876 0.408134397403028 no 2009 0.454980360166945 2639 23767530 SGTC_342 k048-0088 23.3 µM -0.114247723991371 0.407733591411897 no 2010 0.454520710635325 2589 6820570 SGTC_802 4112-3352 742 µM -0.11462113384481 0.40760455018607 no 2011 0.454372713863581 2757 704594 SGTC_1977 st070720 65.3 µM -0.114882021783543 0.407514399703375 no 2012 0.454269317637485 2715 682188 SGTC_1315 1237-0019 3.69 µM -0.11569630114301 0.407233054945693 no 2013 0.453946618913543 2659 825140 SGTC_2407 paclitaxel 400 µM -0.117654247419201 0.406556753616504 no 2014 0.453170810085643 2884 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_231 b-estradiol 524 µM -0.119252686002482 0.406004837627347 no 2015 0.452537583510803 2619 450 A steroid. SGTC_556 4058-0063 51.5 µM -0.122910593977034 0.404742523235131 no 2016 0.451088948229363 2638 6615692 SGTC_779 1360-0071 233 µM -0.126158508296797 0.403622524188407 no 2017 0.449803227230729 2821 7566 SGTC_2009 4012297 12.05 µM -0.127554858330533 0.40314125412917 no 2018 0.449250628525076 2729 45595307 SGTC_88 0180-0332 8.668 µM -0.130864858682757 0.402001007003628 no 2019 0.447941107134244 2620 3101745 SGTC_3119 9125183 49.47 µM -0.134390435320067 0.400787413869567 no 2020 0.446546922267513 2661 22695334 SGTC_2924 9010168 62.78 µM -0.134876876561516 0.400620043285416 no 2021 0.446354611150312 2736 2993929 SGTC_800 3448-7362 155 µM -0.135038872602027 0.400564309107296 no 2022 0.446290569955489 2674 15991913 SGTC_3282 9108498 15.4605 µM -0.138905405662438 0.399234645018007 no 2023 0.444762449640809 2747 16459645 SGTC_2516 gossypol 71.55 µM -0.139740354156255 0.39894766698099 no 2024 0.444432570599831 2776 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_2843 9000894 45.46 µM -0.14137740527949 0.398385158927315 no 2025 0.443785901474966 2629 2242070 SGTC_319 1348-1596 45.5 µM -0.141587672536031 0.398312924149776 no 2026 0.443702852359751 2836 5380505 SGTC_2764 methyldopa 94.69 µM -0.142314182661703 0.398063367200028 no 2027 0.443415922202149 2769 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent. SGTC_2809 7964133 12.99 µM -0.142390881929401 0.398037023356961 no 2028 0.443385632084608 2698 1253665 SGTC_1269 0831-0796 3.05 µM -0.14325628367894 0.397739816669191 no 2029 0.443043890108065 2748 927758 SGTC_2960 9079389 5.97 µM -0.143946439906961 0.397502837432282 no 2030 0.44277138189286 2750 16457355 SGTC_1204 4049-0315 18.3 µM -0.144687173007025 0.397248533678802 no 2031 0.442478933520699 2926 588402 SGTC_834 0312-0008 75.7 µM -0.145524719508826 0.396961045181417 no 2032 0.442148300071652 2640 6385573 YIL048W NEO1 SGTC_2678 equilin 100 µM -0.14573527056387 0.396888782165939 no 2033 0.442065188363625 2737 3247 Equilin is an estrone commonly used hormone replacement therapy SGTC_524 r073-0010 27.8 µM -0.146193198372182 0.396731629450985 no 2034 0.441884437393673 2638 2772106 SGTC_2125 5246583 200 µM -0.146578198624015 0.396599517158686 no 2035 0.441732481384931 2693 835267 SGTC_56 0957-0365 83.25 µM -0.14720797012348 0.39638343755263 no 2036 0.441483934943321 2643 6752360 SGTC_1166 k206-0078 225 µM -0.148628780540181 0.395896063187969 no 2037 0.440923280827843 2656 5404595 SGTC_442 cape 100 µM -0.15095691965359 0.395097803894076 no 2038 0.440004849753098 2740 5281787 SGTC_1646 st011709 75.6 µM -0.155082830217087 0.393684217717124 no 2039 0.43837800895881 2699 5757843 SGTC_1856 st057054 55.7 µM -0.15739619247624 0.392892243489256 no 2040 0.437466307010578 2926 1266018 SGTC_1761 st044296 37 µM -0.157864201018835 0.39273207563828 no 2041 0.437281903865338 2670 1826700 SGTC_1163 k060-0048 49.9 µM -0.158215523839789 0.392611853395958 no 2042 0.437143485783838 2690 6809982 SGTC_1061 3448-9325 110 µM -0.158429418806413 0.392538663815515 no 2043 0.437059216827342 2642 723482 SGTC_2189 6047310 154.431 µM -0.158451192273537 0.392531213685324 no 2044 0.437050638817567 2667 711535 SGTC_1497 4476-2978 41.3 µM -0.159666188354146 0.392115546380221 no 2045 0.43657201846332 2771 1528379 SGTC_3154 9100113 49.47 µM -0.161126758185372 0.391616027776539 no 2046 0.435996782803618 2709 25237525 SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM -0.162383038686375 0.391186519523104 no 2047 0.435502113369268 2685 442882 SGTC_41 0478-0632 82.643 µM -0.162881004997541 0.391016307096023 no 2048 0.435306063454117 2707 3750424 SGTC_166 k072-0058 166.424 µM -0.164288520384599 0.390535310005107 no 2049 0.434752009156928 2699 5846229 SGTC_258 haloperidol 50.781 µM -0.166367776865361 0.389825062180729 no 2050 0.433933765434964 2727 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_1409 3909-8004 61.9 µM -0.166913830929686 0.389638597861131 no 2051 0.433718925155528 2735 2119279 SGTC_2133 5320837 200 µM -0.168776797374936 0.389002631061559 no 2052 0.432986104748626 2839 2841355 SGTC_2423 st077119 87.2 µM -0.169781121347511 0.388659905003223 no 2053 0.432591137173603 2645 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae). SGTC_1746 st038117 42 µM -0.171253240813921 0.388157700149244 no 2054 0.432012322827818 2820 2898218 SGTC_518 1021-0119 62.6 µM -0.171881504829935 0.387943428466194 no 2055 0.431765343595129 2767 1097762 SGTC_2370 9071495 200 µM -0.172016256299806 0.387897475437638 no 2056 0.431712374407704 2769 21791103 SGTC_1278 0874-0585 172 µM -0.172235197687793 0.387822815259541 no 2057 0.43162631379119 2762 766306 SGTC_237 nikkomycin 200 µM -0.173025921697103 0.387553208717961 no 2058 0.431315526172843 2847 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine. SGTC_3093 9117344 49.47 µM -0.17401541389297 0.387215906234534 no 2059 0.430926674256167 2863 24824913 SGTC_1078 idebenone 36.1 µM -0.174769662818154 0.386958851686824 no 2060 0.43063031348961 2787 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen. SGTC_885 0865-0106 16.8 µM -0.175466301873591 0.386721475115431 no 2061 0.430356623589107 2712 2793380 SGTC_1787 fluconazole 80 µM -0.175898306511351 0.386574292791584 no 2062 0.430186917908345 2752 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C SGTC_1007 4101-0031 70 µM -0.177005803213309 0.386197047482489 no 2063 0.429751915626174 2890 1146276 SGTC_192 3455-0609 60.9 µM -0.177746672415598 0.385944746092855 no 2064 0.429460964769832 2842 3769639 SGTC_1656 st012921 11 µM -0.177929479895639 0.385882498819794 no 2065 0.429389179316749 2833 6732821 SGTC_1220 1838-0075 193 µM -0.179074809809941 0.385492572606409 no 2066 0.428939480566243 2748 5529645 SGTC_276 colchicine 750 µM -0.179192173973647 0.385452622645216 no 2067 0.428893404268292 2831 2833 A microtubule depolymerizer. SGTC_3283 9109332 35.8195 µM -0.179733479738205 0.385268381588838 no 2068 0.428680904200989 2687 17027281 SGTC_3350 9150499 3.57 µM -0.179934505364305 0.38519996627118 no 2069 0.428601992957108 2708 4910996 YPR165W RHO1 SGTC_222 nsc-310342 10.666 µM -0.180743214673625 0.384924773280276 no 2070 0.428284568480936 2718 432556 SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM -0.181020406094739 0.384830462067133 no 2071 0.428175779432944 2740 6708561 SGTC_1664 st014217 9.02 µM -0.181887456472164 0.384535502101495 no 2072 0.427835524291414 2737 3982782 SGTC_2107 5363541 170.161 µM -0.183294646521 0.384056935525255 no 2073 0.427283417349542 2740 244052 SGTC_1877 wortmannin 25 µM -0.185758331668116 0.383219495003843 no 2074 0.426317141120044 2853 312145 A covalent inhibitor of PI 3-kinase. SGTC_637 1181-0519 7.26 µM -0.186717704107317 0.382893538424624 no 2075 0.425940987173588 2738 6252091 YGR060W ERG25 SGTC_61 0978-8327 98.565 µM -0.187415230467124 0.382656598768035 no 2076 0.425667540993476 2714 6150059 YHR072W ERG7 SGTC_314 1671-0008 2.74 µM -0.187903044777352 0.38249092136289 no 2077 0.425476327933638 2728 3913060 SGTC_2693 st077581 40.7 µM -0.18817970178176 0.382396969314964 no 2078 0.425367891929823 2790 25238761 SGTC_2078 5212016 200 µM -0.188747368920985 0.382204212610933 no 2079 0.425145411881702 2708 1899708 SGTC_363 0455-0021 3.06 µM -0.189111124863557 0.382080711209442 no 2080 0.425002861215811 2735 4597466 SGTC_1482 3346-2049 8.48 µM -0.189830704379088 0.381836436934853 no 2081 0.424720897366875 2834 3826804 SGTC_1304 1165-0502 251 µM -0.190216352881462 0.3817055409343 no 2082 0.424569798657291 2782 767425 SGTC_1811 st050069 61.5 µM -0.191895198953485 0.381135868327381 no 2083 0.423912149118644 2739 3877702 SGTC_2570 licareol 100 µM -0.192096608364351 0.381067542574082 no 2084 0.423833265786068 2857 443158 SGTC_1314 1222-0010 41.1 µM -0.192173371830593 0.381041502454569 no 2085 0.423803201668106 2791 3526027 SGTC_2797 7859098 81.82 µM -0.192507615018892 0.380928124947617 no 2086 0.42367230177369 2772 972681 SGTC_860 0443-0016 25.1 µM -0.193792100396173 0.380492514192543 no 2087 0.423169336364184 2758 5337942 SGTC_2976 9009005 19.48 µM -0.195717880012119 0.379839703682255 no 2088 0.422415494418403 2970 2993148 SGTC_3344 9148862 3.898 µM -0.195792715497978 0.379814342467896 no 2089 0.422386205958436 2900 4905352 SGTC_2185 6113692 200 µM -0.200986013860991 0.378055638877 no 2090 0.42035475512245 2888 874150 SGTC_1224 0823-0416 294 µM -0.203069038363029 0.377350932547857 no 2091 0.419540535662257 2898 3598164 SGTC_2539 epi(13)torulosol 80 µM -0.203261656485109 0.377285788650138 no 2092 0.419465261799016 2861 6708597 SGTC_930 2810-3379 265 µM -0.203312373631914 0.377268636573582 no 2093 0.419445442370076 2975 1015764 SGTC_2582 agaric acid 100 µM -0.203682408264342 0.377143501564661 no 2094 0.419300845094321 2872 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase. SGTC_872 0588-0139 234 µM -0.205692264577707 0.376464051941359 no 2095 0.418515650666947 2764 2047100 SGTC_109 0132-0036 33.701 µM -0.205756724921521 0.376442266875398 no 2096 0.41849047317565 2732 67274 A color developer. SGTC_3085 9117376 49.47 µM -0.206677697314408 0.376131057368929 no 2097 0.418130788148271 2848 16480349 SGTC_1285 0929-0069 65.5 µM -0.207783226132216 0.375757590019266 no 2098 0.417699115193002 2813 1206237 SGTC_3108 9121785 49.47 µM -0.211595639228038 0.374470583434332 no 2099 0.416211255847804 2701 17140271 SGTC_288 1315-0019 35.1 µM -0.213241965903975 0.373915242355371 no 2100 0.41556911843899 2848 6811474 SGTC_2686 alizarin 95.37 µM -0.213436971924947 0.373849479975272 no 2101 0.415493072696382 2848 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1 SGTC_1184 1269-1718 139 µM -0.213475875830197 0.373836360750931 no 2102 0.415477901869769 2930 5403821 SGTC_2104 5389443 200 µM -0.213930976212108 0.373682902081619 no 2103 0.415300441929358 2968 2244536 SGTC_55 0767-0285 6.563 µM -0.215109405293814 0.373285631960716 no 2104 0.414841010593056 2906 3116166 SGTC_631 k072-0230 41.5 µM -0.215237363632957 0.373242502948126 no 2105 0.414791130778203 2898 5773147 SGTC_1382 3002-2117 298 µM -0.215381438504068 0.373193943676792 no 2106 0.414734970175048 2914 1497314 SGTC_3345 9148410 3.559 µM -0.217026068113757 0.372639777446724 no 2107 0.414094014820724 2922 4903596 SGTC_83 0170-0301 39.027 µM -0.2180335859041 0.37230041934447 no 2108 0.413701471553837 2783 3089716 SGTC_252 miconazole 1.30953 nM -0.218446218067968 0.372161462739122 no 2109 0.413540729057275 2881 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_515 4092-1064 102 µM -0.219032463595341 0.371964069315101 no 2110 0.413312379707059 3018 717353 SGTC_427 1354-0053 47.3 µM -0.219133732268889 0.371929974772631 no 2111 0.413272937366074 3036 6813657 SGTC_3264 9137442 49.47 µM -0.220003105262776 0.371637320719477 no 2112 0.412934368151201 3025 17015726 SGTC_3295 9122362 53.5725 µM -0.221128665440281 0.371258537447914 no 2113 0.4124961254418 2906 4730473 SGTC_1862 st057513 3.81 µM -0.221481155348311 0.371139940104253 no 2114 0.412358904063409 2820 5393163 SGTC_1337 1486-1011 40.3 µM -0.223488535913275 0.370464778449005 no 2115 0.411577652264558 2802 X1337 SGTC_2807 7945238 51.95 µM -0.224434045077109 0.370146904267705 no 2116 0.411209791068756 2918 17148797 SGTC_1998 st075797 76.8 µM -0.225923344004201 0.369646391325062 no 2117 0.410630520642306 2777 24208315 SGTC_2395 5646831 180.19 µM -0.227441081400422 0.369136548128006 no 2118 0.410040389425999 2975 6808628 SGTC_1157 4092-0394 27.6 µM -0.228227233996429 0.368872551649419 no 2119 0.409734795201947 2986 3659885 SGTC_3098 9119039 49.47 µM -0.228447525108853 0.368798587179839 no 2120 0.409649173190312 2791 17161528 SGTC_1436 4092-1007 8.32 µM -0.228489057318117 0.368784642959039 no 2121 0.409633031072977 2824 2881121 SGTC_2235 salicylic acid 500 µM -0.228939675606474 0.368633361347104 no 2122 0.409457901355527 2812 338 A COX inhibitor and kinase inhibitor. SGTC_1806 st050005 60.3 µM -0.229095812630808 0.368580947758976 no 2123 0.409397223981055 2807 5194765 SGTC_1464 k208-0027 110 µM -0.232033964170533 0.367595097474755 no 2124 0.408255816996977 3014 X1464 SGTC_2546 rhodinyl acetate 100 µM -0.232228617112084 0.367529815481992 no 2125 0.408180226000401 2918 6708682 SGTC_115 0527-0192 112.043 µM -0.233399566128003 0.367137187710249 no 2126 0.407725575025772 2891 4233931 SGTC_1837 st055472 66.5 µM -0.233483395779524 0.367109084338105 no 2127 0.407693030773041 2985 676091 SGTC_3073 9114972 49.47 µM -0.23381606204299 0.366997567051518 no 2128 0.40756388973308 2941 41905075 SGTC_2827 7993847 71.43 µM -0.234515768463197 0.366763046202074 no 2129 0.407292296506356 2929 2985692 SGTC_1324 1418-0026 34.4 µM -0.236780119107719 0.366004444230929 no 2130 0.406413687841184 2928 1372513 SGTC_923 1900-2434 73.3 µM -0.240319965747238 0.364819575862966 no 2131 0.405041109026312 2799 5910570 SGTC_310 1273-0058 1.06 µM -0.242582265398802 0.364063006788756 no 2132 0.404164510536477 2941 2734232 SGTC_2679 rapamycin 1 nM -0.24262832886081 0.364047607516174 no 2133 0.404146666794518 2925 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2 SGTC_1305 1181-0477 144 µM -0.243714385165264 0.363684596482724 no 2134 0.40372601575257 2964 6252086 SGTC_2994 9053520 71.4286 µM -0.244411027620586 0.363451810231883 no 2135 0.403456250958029 2985 4647384 SGTC_2216 7189485 200 µM -0.244442833876625 0.363441183229248 no 2136 0.403443935537167 2944 731273 SGTC_151 3013-0144 2.285 µM -0.244558806162811 0.363402435837087 no 2137 0.403399031738628 3051 906558 YHR107C CDC12 SGTC_216 k038-0035 28.382 µM -0.245043221121045 0.363240603522517 no 2138 0.403211482844408 2908 4444231 YPR107C YTH1 SGTC_2236 dapsone 200 µM -0.246750766417955 0.362670345283998 no 2139 0.402550557555443 2863 2955 A bacterial DFR inhibitor. An anti-cancer agent. SGTC_1047 2043-3044 82 µM -0.247956335706256 0.362267912125873 no 2140 0.402084095493026 2855 669592 SGTC_1690 st023502 41.2 µM -0.248097814146581 0.362220694933011 no 2141 0.402029363408529 2926 24207482 SGTC_1869 3',7'-dimethoxyflavone 40.3 µM -0.249600316946734 0.361719377232178 no 2142 0.401448226727855 2852 688664 SGTC_1875 nocodazole 6 µM -0.250126019177627 0.361544029987731 no 2143 0.40124494748668 2886 4122 A microtubule depolymerizer. YJL014W CCT3 SGTC_1673 st016611 27.3 µM -0.25136661651124 0.361130345801147 no 2144 0.400765337708085 3055 5226799 SGTC_75 0159-0059 199.013 µM -0.251964148374931 0.3609311533295 no 2145 0.400534387686293 3159 5377270 SGTC_2908 7930301 100 µM -0.253910269280889 0.360282658597387 no 2146 0.399782440496911 2857 2223178 SGTC_581 0958-0271 211 µM -0.25443288947849 0.360108577217285 no 2147 0.399580572326847 2860 4591145 SGTC_1950 st077106 7.18 µM -0.255755498404194 0.359668154465298 no 2148 0.399069819178123 2944 13831864 SGTC_1906 st060206 94.7 µM -0.256232336960471 0.359509415058237 no 2149 0.398885720300409 3011 5133468 SGTC_2036 5160441 105 µM -0.258467769061261 0.358765563996763 no 2150 0.398022960285939 2906 134534 YIL048W NEO1 SGTC_2880 9042983 58.44 µM -0.260580085371752 0.358063172158587 no 2151 0.397208174401012 3013 6464714 SGTC_2200 6600604 21.907 µM -0.261253907178441 0.357839212423062 no 2152 0.39694835460359 2860 2904777 SGTC_3298 9116858 71.43 µM -0.261547489223843 0.357741649167454 no 2153 0.396835166231261 3018 2506942 SGTC_186 3455-3465 67.277 µM -0.262782461003471 0.357331344887714 no 2154 0.396359127333526 2855 755278 SGTC_74 000s-0487 160.283 µM -0.263119187048294 0.357219500363077 no 2155 0.396229357863233 2830 677548 SGTC_3176 9106582 49.47 µM -0.264189990460659 0.356863911495837 no 2156 0.395816761803956 2940 17018027 SGTC_533 1222-0222 6.71 µM -0.266851237395311 0.355980712422933 no 2157 0.394791851213793 3070 3982874 SGTC_675 1309-0189 238 µM -0.268479204130283 0.355440812732584 no 2158 0.394165240082868 2919 4246530 SGTC_3019 9081971 49.47 µM -0.268727335636504 0.355358547717213 no 2159 0.394069757249238 3048 16451803 SGTC_1348 1493-0373 93.8 µM -0.26942238925312 0.355128146942393 no 2160 0.393802329403037 2945 3010129 SGTC_94 0334-0113 514.748 µM -0.271212198710166 0.354535093501594 no 2161 0.393113915632412 2905 6795178 SGTC_1776 st049249 45.9 µM -0.275426628911586 0.353140036158956 no 2162 0.391494244004588 2939 1822314 SGTC_3199 9111318 49.47 µM -0.277358097327109 0.352501340630863 no 2163 0.390752576686908 3027 8548020 SGTC_1229 0139-0193 12.2 µM -0.279048635723992 0.351942656547236 no 2164 0.390103750323827 3042 3090752 SGTC_2606 farnesol 9.78 µM -0.2800012942905 0.351627965454665 no 2165 0.389738255946313 3082 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_1317 1273-0028 910 nM -0.280399760546078 0.351496370488923 no 2166 0.389585410369633 2914 5917803 YLR359W | YHR072W ADE13 | ERG7 SGTC_576 1073-0113 22.7 µM -0.28118221695694 0.35123801314063 no 2167 0.389285321738087 2957 5439563 SGTC_1552 6-methylflavone 10.6 µM -0.283018858671682 0.350631847142977 no 2168 0.388581190322463 2929 689013 SGTC_202 3594-0513 34.79 µM -0.286468870236072 0.349494232462464 no 2169 0.387259516395189 2910 708429 SGTC_2040 5100729 123 µM -0.287249715381772 0.349236941853649 no 2170 0.386960561063534 2907 11840 YJR013W | YDR381W GPI14 | YRA1 SGTC_1058 3448-5425 97.3 µM -0.2879956027991 0.348991234598125 no 2171 0.386675052300511 2881 7279705 SGTC_1596 piperlongumine 63 µM -0.290627992472122 0.348124589817978 no 2172 0.38566792441856 3075 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_1223 0764-0573 147 µM -0.292890946195918 0.347380205341183 no 2173 0.384802754717415 2912 1609797 SGTC_1199 1638-0010 4.46 µM -0.294082572022822 0.346988463723863 no 2174 0.384347403936685 2906 3111136 SGTC_827 3253-0474 693 µM -0.29411897330012 0.346976499539229 no 2175 0.384333496583601 3057 5402065 SGTC_416 estradiol valerate 100 µM -0.296165603098046 0.346304069502368 no 2176 0.383551807913971 2994 13791 A steroid. SGTC_3038 9091290 49.47 µM -0.299462335095692 0.345221931185128 no 2177 0.382293653183301 3091 25236843 SGTC_194 1486-1323 56.904 µM -0.299495147915182 0.345211166856087 no 2178 0.382281136818332 2975 5178754 SGTC_2953 9074162 66.49 µM -0.300944665918901 0.344735773845564 no 2179 0.381728344840862 3057 16451992 SGTC_2988 9073640 71.4286 µM -0.302191257033413 0.344327129968831 no 2180 0.381253134377431 3147 9102229 SGTC_491 tetrandrine 80.3 µM -0.303588045284291 0.343869465932995 no 2181 0.380720880229915 3034 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_153 4077-0274 519.67 µM -0.303758937966252 0.343813487854365 no 2182 0.380655776070521 3249 3121976 SGTC_3035 9091303 49.47 µM -0.30496384686564 0.343418901804885 no 2183 0.380196843761535 2944 25237002 SGTC_659 k018-0002 107 µM -0.306215302926674 0.343009252999201 no 2184 0.379720360823927 3081 6797879 YHR007C ERG11 SGTC_2870 9038528 12.99 µM -0.306292347255174 0.342984039505211 no 2185 0.379691032705917 3064 6463316 SGTC_3170 9103054 49.47 µM -0.306309710399973 0.342978357346407 no 2186 0.379684423251235 3003 16432970 SGTC_2738 aclarubicin 5.55 µM -0.307407824621375 0.342619067252161 no 2187 0.379266486581548 3011 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31 SGTC_2311 7694451 200 µM -0.307468876084199 0.342599096103322 no 2188 0.379243254841287 2998 2163142 SGTC_1407 3909-7909 12.3 µM -0.308062557362281 0.342404914088197 no 2189 0.379017365736564 2969 4411780 SGTC_1188 1403-0014 4.57 µM -0.308742865052222 0.342182449410629 no 2190 0.378758567043083 2966 9614867 SGTC_326 k292-0812 17.5 µM -0.309085307330193 0.342070489455916 no 2191 0.378628317702479 3028 3579357 SGTC_321 4534-3890 65.3 µM -0.309089446199079 0.342069136356342 no 2192 0.37862674355082 3055 699746 SGTC_2461 5755302 26.15 µM -0.309464964646142 0.341946378441889 no 2193 0.378483929582391 3092 2788904 SGTC_1751 st044839 27.194 µM -0.309473936672102 0.341943445668588 no 2194 0.378480517621026 2949 5291326 SGTC_2048 5246248 200 µM -0.309643294229684 0.341888087907474 no 2195 0.378416114608988 3071 677046 SGTC_1748 st037455 53.6035 µM -0.310111297727052 0.341735129680234 no 2196 0.37823816057905 3133 580690 SGTC_2380 9035439 200 µM -0.310195875040773 0.341707489931504 no 2197 0.378206003586835 3094 6462575 SGTC_1714 st033236 13.627 µM -0.312147890359446 0.34106981011202 no 2198 0.377464066116572 3147 2916566 SGTC_84 0443-0269 128.823 µM -0.313695332328699 0.340564617644218 no 2199 0.376876223111807 3037 6150058 SGTC_1712 st032288 53.4 µM -0.314130163020546 0.340422710143033 no 2200 0.376711090708847 3050 2883011 SGTC_163 TUB2.036 7.546 µM -0.31516860363665 0.340083905271954 no 2201 0.376316821176208 3076 15992207 YJR013W GPI14 SGTC_3238 9133470 49.47 µM -0.316424729712998 0.339674250194927 no 2202 0.375840074457651 3101 3534688 SGTC_1568 digitonin 820 nM -0.317069935817387 0.339463905422277 no 2203 0.375595268271089 3133 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1 SGTC_1657 st012939 43.4 µM -0.318900164088117 0.338867501775462 no 2204 0.374901109944002 3111 24207257 SGTC_2302 7771753 200 µM -0.319387672260724 0.338708708931813 no 2205 0.374716278907367 3040 2203047 SGTC_2965 9082772 38.63 µM -0.320242796140423 0.338430244281882 no 2206 0.374392141703653 3166 16459634 SGTC_399 oxolinic acid 75 µM -0.32230127300304 0.337760279273183 no 2207 0.373612234416818 2975 4628 A DNA gyrase inhibitor. SGTC_626 0214-0009 33 µM -0.323295736523692 0.337436798742964 no 2208 0.373235641273568 3093 3437874 SGTC_1619 st003326 88.7 µM -0.323488113924683 0.337374235801106 no 2209 0.373162803887402 3127 2849032 SGTC_814 3342-0569 96 µM -0.324903522918379 0.336914069793319 no 2210 0.372627045260046 2993 4346283 SGTC_3110 9122132 49.47 µM -0.326313223917099 0.336456002016959 no 2211 0.372093692048992 3134 918317 SGTC_684 1140-0066 328 µM -0.327044279815131 0.336218548444277 no 2212 0.371817197289391 3043 6813534 SGTC_174 3553-0389 74.3 µM -0.32745993353206 0.336083569479542 no 2213 0.371660021164356 3123 738071 SGTC_607 4491-0986 66.8 µM -0.328290784583075 0.33581382311148 no 2214 0.371345905632614 3126 698981 YDR232W HEM1 SGTC_1770 st043884 66.3 µM -0.329472403432928 0.335430341187964 no 2215 0.370899324743122 2955 670149 SGTC_783 0848-0141 92.7 µM -0.329662633957294 0.335368619886614 no 2216 0.370827445271316 2946 6755076 YHR007C | YLR033W ERG11 | RSC58 SGTC_2019 4016004 108 µM -0.329735335564528 0.335345032638492 no 2217 0.370799975827625 3062 45595336 SGTC_1956 st077085 54 µM -0.330000417363469 0.335259035221634 no 2218 0.370699823379156 3006 24208685 SGTC_590 k048-0076 22.4 µM -0.332333188416077 0.334502614040369 no 2219 0.369818840958286 3106 6832814 SGTC_2095 5432005 200 µM -0.332669296417439 0.334393683375182 no 2220 0.369691964294227 2984 783734 SGTC_3232 9132874 49.47 µM -0.333618651024184 0.334086078353824 no 2221 0.369333671192192 3006 3784940 SGTC_2339 9000433 200 µM -0.335085198981549 0.333611114041249 no 2222 0.36878040880302 3044 2988954 SGTC_1449 4112-4002 201 µM -0.335473612668775 0.333485364857201 no 2223 0.368633923325051 3037 2059539 SGTC_2444 5485484 36.41 µM -0.335967459406829 0.333325508670275 no 2224 0.368447702622933 3117 6790631 SGTC_2208 7283366 200 µM -0.336263249679601 0.333229777050243 no 2225 0.368336180234592 3080 898663 SGTC_1617 st002906 78 µM -0.337626080395215 0.332788841464723 no 2226 0.367822492906793 2975 5150859 SGTC_375 3970-0961 9.27 µM -0.339456253374681 0.332197063864858 no 2227 0.367133023691713 3037 2898222 SGTC_1376 2910-0861 41.3 µM -0.339810223994289 0.332082657389908 no 2228 0.36699972398753 2988 1112859 SGTC_602 3130-1533 38.1 µM -0.341229376372562 0.331624131876736 no 2229 0.366465454921457 3114 720941 SGTC_1104 tacrolimus 29.8 µM -0.341533692153647 0.331525840822523 no 2230 0.366350922641617 3042 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41 SGTC_2144 5628481 200 µM -0.341622614119586 0.331497122077351 no 2231 0.366317458219535 3015 2818399 SGTC_1850 st056238 17 µM -0.341972419654042 0.331384156502283 no 2232 0.366185824123302 2994 5393177 SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM -0.342170471552419 0.331320204775933 no 2233 0.366111302886854 3111 1377 SGTC_119 0121-0043 24.815 µM -0.343517948132412 0.330885230017361 no 2234 0.365604420374228 3032 1092378 SGTC_2938 9059746 27.26 µM -0.347175580943938 0.329705672676782 no 2235 0.364229707421987 3123 6471769 SGTC_2566 crystal violet carbinol 226 nM -0.347568770571983 0.329578972672473 no 2236 0.364082031559075 3155 68050 Cationic dye that binds acidic phospholipids including cardiolipin. SGTC_1970 st070122 35.8 µM -0.347663616587945 0.329548412762701 no 2237 0.36404641190204 3190 102928 SGTC_711 k292-0785 179 µM -0.347830805511434 0.32949454634062 no 2238 0.363983626546405 2987 4146315 SGTC_2791 5663188 71.43 µM -0.350340751420888 0.328686295293662 no 2239 0.363041492769868 3192 54690634 SGTC_1448 4255-0083 152 µM -0.350912646026063 0.328502246060635 no 2240 0.362826941950245 3177 5399660 SGTC_333 3486-0131 40.1 µM -0.352147181461972 0.328105085191826 no 2241 0.362363943001271 3164 6744690 SGTC_2263 7948595 193.29 µM -0.352557914380793 0.327972991856663 no 2242 0.362209946717258 2987 2971371 SGTC_234 nsc-17383 10.7 µM -0.354424513548389 0.327372957439923 no 2243 0.361510383092275 3172 408974 SGTC_1097 itavastatin 7.23 µM -0.354779882887551 0.327258771359534 no 2244 0.361377250210125 3067 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49 SGTC_653 0203-0016 55.2 µM -0.354790670264067 0.327255305448727 no 2245 0.361373209171356 3082 295302 SGTC_356 1634-0012 32.5 µM -0.356186585441237 0.326806933138314 no 2246 0.360850418659052 3153 735457 SGTC_2428 5615643 7.78 µM -0.35698512519799 0.326550552032113 no 2247 0.360551470713464 3134 2253075 SGTC_1277 0873-0036 22 µM -0.359052897854784 0.325887048806588 no 2248 0.359777758644155 3134 5965735 SGTC_2646 retinol 96.75 µM -0.360692405118247 0.325361358130757 no 2249 0.35916470145025 3125 445354 A vitamin A analog and teratogen. SGTC_1529 apigenin 74 µM -0.361499417460255 0.325102725628304 no 2250 0.358863070190706 3277 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_2774 tamoxifen 10.92 µM -0.362691348625635 0.324720887899874 no 2251 0.358417731550965 3064 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  SGTC_821 1114-0266 29.2 µM -0.363501864462326 0.324461342539463 no 2252 0.358115010199402 3117 3123235 SGTC_96 0929-0093 37.281 µM -0.363962869559464 0.324313756383686 no 2253 0.357942868160888 3040 6991579 SGTC_3022 9087993 49.47 µM -0.364904346828646 0.324012437628859 no 2254 0.357591404714728 3133 17173644 SGTC_2921 7974240 10.71 µM -0.365616742941775 0.323784512638746 no 2255 0.357325539914161 3168 2979074 YDR527W RBA50 SGTC_2787 5284540 71.43 µM -0.365954543742605 0.323676459273165 no 2256 0.357199497525372 3089 736958 SGTC_2803 7707263 71.43 µM -0.366872832066725 0.323382798742853 no 2257 0.356856938711976 3043 2199229 SGTC_1929 genistein trimethyl ether 50.5 µM -0.366905552784676 0.323372336973413 no 2258 0.356844734683737 3233 136420 SGTC_488 nitrendipine 139 µM -0.369526822248829 0.322534694855671 no 2259 0.355867542201042 3066 4507 Dihydropyridine L-type calcium channel blocker. SGTC_1131 3454-3128 32.3 µM -0.370840055367419 0.322115381569654 no 2260 0.355378332653302 3205 710982 SGTC_1487 3970-0795 2.82 µM -0.371429282833334 0.321927315680105 no 2261 0.355158909234551 3155 3765103 SGTC_2911 7942208 15.64 µM -0.373445441801378 0.321284156032797 no 2262 0.354408472007724 3144 1243384 SGTC_832 4083-0019 164 µM -0.374957286262015 0.320802225191128 no 2263 0.353846116775527 3190 1990758 SGTC_2081 5214970 32.255 µM -0.374998140460154 0.320789206278219 no 2264 0.353830924806881 3171 2063512 SGTC_2620 irigenin 100 µM -0.375723099150895 0.320558222034821 no 2265 0.353561381700918 3229 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro. SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM -0.37800329316505 0.319832166458212 no 2266 0.352714073790769 3008 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding. SGTC_3316 9136639 10.545 µM -0.378166834783004 0.319780118285785 no 2267 0.35265333061092 3172 4903665 SGTC_1283 0922-0125 16.4 µM -0.380165748375009 0.319144238169917 no 2268 0.351911191361037 3158 3360884 SGTC_1462 k081-0014 26.5 µM -0.382303120865923 0.318464900732227 no 2269 0.35111827003775 3079 3270634 SGTC_2724 maprotiline 69.64 µM -0.385168104120646 0.317555258057545 no 2270 0.350056436495795 3214 4011 A tricyclic antidepressant. SGTC_281 1672-3440 14.9 µM -0.385675941873733 0.317394132376811 no 2271 0.349868341261001 3182 6833000 SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM -0.385824239508368 0.31734708734418 no 2272 0.349813421062299 3144 676296 Flavone; oxidizing agent. SGTC_2318 6029776 164 µM -0.38608087648198 0.317265680375625 no 2273 0.349718386151308 3262 818325 SGTC_1754 st042065 16.137 µM -0.386801316585681 0.317037199195784 no 2274 0.349451651228103 3169 1126236 YIL048W NEO1 SGTC_2868 9035608 32.47 µM -0.38728913067325 0.316882532882403 no 2275 0.34927108568691 3046 6462614 SGTC_2182 6325192 200 µM -0.388333513102304 0.316551508640843 no 2276 0.348884619789321 3182 736248 SGTC_1550 gossypolone 36.6 µM -0.389850388934264 0.316070985982573 no 2277 0.348323590430474 3084 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_1038 k292-0204 154 µM -0.39143877840786 0.315568141741198 no 2278 0.34773646665746 3035 4454212 SGTC_2703 st077852 53.4 µM -0.393212433365068 0.315007050411809 no 2279 0.347081293666273 3202 6281836 SGTC_2958 9077254 16.72 µM -0.394712109408093 0.314532964411741 no 2280 0.34652768246122 3296 16457351 SGTC_697 0508-1955 564 µM -0.395455671936808 0.314298018545105 no 2281 0.346253314900511 3258 6243113 SGTC_2330 7979373 200 µM -0.397733123861062 0.313578872962677 no 2282 0.345413459070337 3070 1863007 SGTC_1340 1486-1359 257 µM -0.397866164331365 0.313536884949537 no 2283 0.345364421215003 3120 4309068 SGTC_1390 3413-2614 145 µM -0.398257816485383 0.313413292258386 no 2284 0.345220075839202 3155 3421432 SGTC_1626 st003712 1.76 µM -0.398766215479242 0.313252889306031 no 2285 0.345032736409316 3235 24207035 SGTC_1404 3909-7820 48.3 µM -0.399199351398674 0.313116260173768 no 2286 0.344873160550995 3208 23741373 SGTC_2481 5478948 45.16 µM -0.399719989070173 0.312952063293302 no 2287 0.344681383827884 3246 77792 SGTC_390 dec-rvkr-cmk 16.7 µM -0.401160854434115 0.312497841698334 no 2288 0.344150849699892 3162 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1 SGTC_2142 5622915 118.518 µM -0.4015217218397 0.312384125611058 no 2289 0.344018024411869 3142 5322196 SGTC_1967 st070177 51.4 µM -0.401587721897925 0.312363329687195 no 2290 0.343993733701364 3256 5729214 SGTC_2221 6807166 181.081 µM -0.402047961643109 0.312218329604175 no 2291 0.343824364626392 3164 674925 SGTC_2664 lyso-paf C-16 73.48 µM -0.402562449424998 0.312056272919269 no 2292 0.343635069270321 3100 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_2329 6138490 200 µM -0.404650005675323 0.311399094371163 no 2293 0.34286739791104 3274 720019 SGTC_604 1000-0114 314 µM -0.406990885407967 0.31066288190099 no 2294 0.342007341268165 3254 1572745 SGTC_2840 9008771 71.43 µM -0.407084129753816 0.3106335719935 no 2295 0.34197309953656 3182 2992978 SGTC_227 fluconazole 33.516 µM -0.408367853899583 0.310230175553273 no 2296 0.34150181511049 3165 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C SGTC_1493 4348-0038 111 µM -0.408773257317906 0.310102829305903 no 2297 0.341353033552334 3220 800424 SGTC_538 2922-0838 53.3 µM -0.409395497616341 0.309907414066885 no 2298 0.341124721626566 3292 777039 SGTC_3101 9120531 49.47 µM -0.411080348286981 0.309378554541441 no 2299 0.340506809654184 3318 24824904 SGTC_1792 st045773 43.6 µM -0.413671589137661 0.308565957607908 no 2300 0.339557318325497 3102 2919270 SGTC_1043 0916-0009 19.3 µM -0.414770460801652 0.308221640915842 no 2301 0.339154972867164 3307 3101130 SGTC_655 k060-0012 42 µM -0.4151687393343 0.308096887312491 no 2302 0.339009190748649 3131 5994525 SGTC_2496 diffractaic acid 79.83 µM -0.416228904580681 0.307764917647362 no 2303 0.33862125538371 3351 94870 An apoptosis inducer which activates caspases. SGTC_1882 5615643 20 µM -0.417345071265412 0.307415582228792 no 2304 0.338213012941871 3215 2253075 SGTC_1435 4092-0789 56.7 µM -0.418902430101097 0.306928455288472 no 2305 0.337643720500208 3230 2248285 SGTC_2981 9013952 38.96 µM -0.419449427893807 0.306757440408985 no 2306 0.337443853530467 3159 2996344 SGTC_11 0438-0307 1.3 µM -0.420504546697985 0.306427684009795 no 2307 0.337058454305951 3234 4011476 SGTC_2502 avocadyne acetate 18.59 µM -0.421259026063522 0.306191982552186 no 2308 0.336782973312332 3069 3952079 SGTC_737 1950-0117 57.9 µM -0.421596612192285 0.30608654566814 no 2309 0.336659739750236 3254 5393513 SGTC_2239 6685329 187.64 µM -0.421808093535863 0.306020502754246 no 2310 0.33658254883185 3265 805680 SGTC_1281 0884-0031 11.8 µM -0.423061611941413 0.30562917452403 no 2311 0.336125154718627 3167 1548255 SGTC_2183 6420625 130.508 µM -0.424729497415923 0.305108831666636 no 2312 0.335516939029281 3224 2897619 SGTC_2899 9053889 58.44 µM -0.424738045687239 0.305106165810999 no 2313 0.335513822901436 3250 6470052 SGTC_364 0083-0097 67.7 µM -0.42474710542085 0.305103340462513 no 2314 0.335510520341005 3265 5207356 SGTC_352 k048-0007 5.11 µM -0.426762231155374 0.304475196683503 no 2315 0.334776259245591 3254 6811911 SGTC_232 clozapine 119 µM -0.427721891337963 0.304176259188411 no 2316 0.334426804946847 3197 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_1803 st050068 52.4 µM -0.428778461177714 0.303847285319072 no 2317 0.334042227472738 3269 3984059 YIL048W | YNL267W NEO1 | PIK1 SGTC_3342 9147791 14.508 µM -0.430545240107751 0.303297535460404 no 2318 0.333399532608164 3157 1838168 SGTC_2505 galangin 7.89 µM -0.431031681362057 0.303146252787565 no 2319 0.333222667338839 3082 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_1654 st012436 41.8 µM -0.431289879981741 0.303065967025761 no 2320 0.333128803915022 3257 4323132 SGTC_3149 9097855 49.47 µM -0.432416503853096 0.302715759494361 no 2321 0.332719362614328 3281 25236625 YMR079W SEC14 SGTC_3130 9127414 49.47 µM -0.433654939725975 0.302331004852688 no 2322 0.332269516338004 3248 1494646 SGTC_528 3492-0019 172 µM -0.433703313678204 0.3023159805881 no 2323 0.332251950005116 3255 2869262 SGTC_1215 3852-0577 11.2 µM -0.43662357843023 0.301409608928122 no 2324 0.331192180064902 3318 2884876 SGTC_2281 7943571 200 µM -0.437795405314534 0.301046249582817 no 2325 0.330767300989398 3378 1244024 SGTC_1141 3253-0389 52.6 µM -0.438428228008439 0.300850106456985 no 2326 0.33053794375815 3256 5402031 SGTC_1688 st021091 57.6 µM -0.438847229004838 0.300720269002631 no 2327 0.330386118046298 3287 3656366 SGTC_3333 9141820 12.094 µM -0.43934935213216 0.300564707490955 no 2328 0.330204209663867 3152 1939433 SGTC_2145 5634607 200 µM -0.443209584105709 0.299369994121637 no 2329 0.328807073616702 3171 308662 SGTC_1910 st062352 60.4 µM -0.444518354630044 0.298965428704842 no 2330 0.328333930818304 3129 2245730 SGTC_2344 7990960 76.95 µM -0.447376976162862 0.298082640068727 no 2331 0.327301448355023 3211 140813 SGTC_897 1000-0139 31.4 µM -0.448301452002594 0.297797401326997 no 2332 0.326967826435396 3321 6151020 SGTC_2861 9024595 19.48 µM -0.448938007517155 0.297601070225047 no 2333 0.326738188642291 3199 16482810 SGTC_374 0880-0231 82.3 µM -0.453685751844408 0.296138603537305 no 2334 0.325027511743733 3248 6833587 SGTC_1650 st011916 45.8 µM -0.454628347617033 0.295848644773651 no 2335 0.324688318612376 3326 242528 SGTC_1827 berberine 7.24 µM -0.454930824320941 0.295755625352045 no 2336 0.324579503144695 3173 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_1941 st076221 61.8 µM -0.455401719104072 0.295610839758666 no 2337 0.324410129367737 3294 2828568 SGTC_2421 5690543 90.72 µM -0.455891361843798 0.295460324312025 no 2338 0.324234050748318 3284 3397993 SGTC_1178 0988-0033 191 µM -0.456642268845362 0.295229565126703 no 2339 0.323964096213275 3300 5392207 SGTC_1400 3771-8998 51.5 µM -0.457659807210004 0.294917000632604 no 2340 0.323598434173472 3201 670767 SGTC_2077 5212015 200 µM -0.458899476543225 0.294536408792503 no 2341 0.323153177345403 3200 780900 SGTC_53 0973-0023 39.979 µM -0.459575180341272 0.294329055929734 no 2342 0.322910588794687 3372 674768 SGTC_857 0438-0306 1.35 µM -0.460203895287517 0.294136183074746 no 2343 0.322684937643327 3310 4686136 SGTC_969 1313-0238 134 µM -0.460997547937736 0.293892795196536 no 2344 0.3224001821679 3188 5212874 SGTC_2838 9002687 71.43 µM -0.463443214013666 0.293143374054381 no 2345 0.321523354721146 3161 6457060 SGTC_695 3505-6186 243 µM -0.464994026626848 0.292668620884837 no 2346 0.320967867133945 3303 1819379 SGTC_2143 5623677 140.463 µM -0.465808894991005 0.292419306922541 no 2347 0.32067614878771 3296 5375313 SGTC_1969 st069479 40.1 µM -0.465995953761699 0.292362089084534 no 2348 0.320609198405541 3335 3895485 SGTC_266 formosanin C 406 nM -0.466018556897324 0.292355175553567 no 2349 0.32060110889096 3279 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1 SGTC_5 0352-0601 109.883 µM -0.467096444415 0.292025574686884 no 2350 0.320215438968411 3263 762456 SGTC_2490 carminic acid 95.39 µM -0.46954118905132 0.291278652501554 no 2351 0.319341425340106 3318 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_3226 9131256 49.47 µM -0.469563718695693 0.291271773358063 no 2352 0.319333375488293 3259 17178073 SGTC_1503 4585-0012 61.3 µM -0.471165814842488 0.290782788002576 no 2353 0.318761164365453 3367 2922052 SGTC_2483 5729050 27.16 µM -0.47693640431081 0.289024700705184 no 2354 0.316703703979177 3397 2865180 SGTC_33 0986-0033 35.816 µM -0.478278551956914 0.288616515314804 no 2355 0.316225979917868 3301 2848082 SGTC_2812 7970281 58.44 µM -0.478726224438698 0.288480425760629 no 2356 0.316066703512705 3364 2233435 SGTC_958 1222-0007 33 µM -0.478930916367629 0.288418210807861 no 2357 0.315993887992023 3389 7312461 SGTC_523 1934-0222 13.7 µM -0.478937843656786 0.288416105408195 no 2358 0.315991423856715 3225 1361595 SGTC_2499 avocadenofuran 51.48 µM -0.481756332889101 0.287560088326759 no 2359 0.314989526501272 3201 6857792 A insecticide and lysyl oxidase inhibitor. SGTC_250 brefeldin a 552.239 µM -0.482347143460811 0.287380802765942 no 2360 0.314779681333831 3263 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.  SGTC_749 1000-0129 128 µM -0.483290691801282 0.287094586191465 no 2361 0.314444674147445 3403 708470 SGTC_1465 k213-0056 144 µM -0.483454288356664 0.2870449744383 no 2362 0.314386604660009 3211 24048857 YMR208W ERG12 SGTC_1260 0700-1617 7.75 µM -0.483838375197901 0.286928513485187 no 2363 0.314250288996557 3335 2853078 SGTC_641 4092-0595 30 µM -0.48435227826818 0.286772725306817 no 2364 0.314067940078458 3338 786260 SGTC_2928 9011484 9.79 µM -0.485992169472212 0.286275865495189 no 2365 0.313486358927166 3342 2994751 SGTC_922 1866-0035 480 µM -0.488240986694271 0.28559517655647 no 2366 0.312689578052222 3239 3156169 SGTC_730 1436-0052 41.2 µM -0.48868860304082 0.285459780640992 no 2367 0.312531086858963 3337 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2 SGTC_1948 st076329 66.6 µM -0.48892031761475 0.285389703146309 no 2368 0.312449055393868 3292 24208413 SGTC_40 0327-0103 19.753 µM -0.489625626683892 0.285176446791929 no 2369 0.312199419474695 3232 409036 SGTC_545 4218-0007 221 µM -0.490075292140878 0.285040526171045 no 2370 0.312040310617969 3351 2840508 SGTC_808 0711-0032 135 µM -0.491055529043413 0.284744336537029 no 2371 0.311693586815365 3340 4252555 SGTC_2463 5473429 200 µM -0.494142520341615 0.283812528246516 no 2372 0.310602765194196 3290 5399405 SGTC_1385 3091-4834 14.1 µM -0.494755995325382 0.283627524861743 no 2373 0.310386184996344 3339 4072814 SGTC_1916 st067606 49.2 µM -0.495889301373145 0.283285909961859 no 2374 0.309986257404806 3301 19590279 SGTC_552 k242-0005 476 µM -0.495938403061655 0.283271113594549 no 2375 0.309968935192682 3377 4088318 SGTC_3179 9107801 49.47 µM -0.496517110643837 0.283096753025792 no 2376 0.30976480912669 3277 4818259 SGTC_1701 st028638 40.4 µM -0.496575337234318 0.283079212611255 no 2377 0.309744274254529 3388 3490878 SGTC_2845 9003024 42.97 µM -0.500277804861959 0.281964938648482 no 2378 0.308439740060136 3463 2990173 SGTC_1560 lithocholic acid 53.1 µM -0.500454306635901 0.281911872464344 no 2379 0.308377611281982 3328 9903 A bile acid which acts as a detergent. SGTC_2663 amphotericin b 100 µM -0.501605905348957 0.281565756432728 no 2380 0.307972382304814 3341 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_2533 agelasine 13.65 µM -0.502132744342619 0.281407481943504 no 2381 0.307787074169552 3465 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase. SGTC_2472 5377652 49.4 µM -0.502215432561036 0.28138264440925 no 2382 0.307757994212109 3330 1610903 SGTC_331 k048-0133 24.5 µM -0.502409105685205 0.28132447384394 no 2383 0.307689887588679 3288 6813582 SGTC_1318 1280-3875 124 µM -0.502773022605152 0.281215185518129 no 2384 0.307561931368767 3340 373245 SGTC_2451 5856223 45.7 µM -0.503522086504814 0.280990297791795 no 2385 0.307298627960278 3301 2179896 SGTC_601 0986-0029 62.9 µM -0.504138012357616 0.28080544657181 no 2386 0.307082198281984 3337 24747981 SGTC_1067 clotrimazole 1.36 µM -0.505859037559221 0.280289245651906 no 2387 0.306477805033676 3306 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_1993 st073995 70.8 µM -0.507133968812324 0.279907141861516 no 2388 0.306030411050932 3320 3098394 SGTC_3067 9117431 49.47 µM -0.507705839535457 0.27973583121846 no 2389 0.305829826284138 3293 17150885 SGTC_1437 4092-1038 11.6 µM -0.509668476381138 0.279148287327539 no 2390 0.305141870744654 3302 3977136 SGTC_1191 1487-1166 10.6 µM -0.510834590497589 0.278799478453873 no 2391 0.304733442867521 3390 3955771 SGTC_63 0099-0242 26.702 µM -0.511484718872009 0.278605103740742 no 2392 0.304505842981835 3405 3898502 YLR359W ADE13 SGTC_3004 9076122 71.4286 µM -0.513031681624082 0.278142859929661 no 2393 0.303964579637243 3400 44782551 SGTC_27 0485-0001 32.618 µM -0.5138869850468 0.277887449673379 no 2394 0.303665503707372 3340 2054479 SGTC_1084 voriconazole 435 nM -0.516277073566886 0.277174330245758 no 2395 0.302830453187887 3407 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_1798 st045719 60.953 µM -0.516763959691337 0.27702917017921 no 2396 0.302660470770842 3356 3980186 SGTC_291 SEC14.278 35.5 µM -0.517158925443131 0.276911442564908 no 2397 0.302522611146532 3407 1068044 SGTC_1730 st033808 45.1 µM -0.517584400391755 0.276784648476576 no 2398 0.302374134035246 3264 1045166 SGTC_1895 st058434 18.3 µM -0.5178752253471 0.276697997261057 no 2399 0.302272664263095 3437 5393175 SGTC_3010 9080089 71.4286 µM -0.518489915511833 0.276514894244941 no 2400 0.302058247157236 3382 17027233 SGTC_540 1187-0821 17.3 µM -0.519396471339427 0.276244959168108 no 2401 0.30174214576079 3301 847520 SGTC_904 1141-0088 396 µM -0.519567791839381 0.276193961493365 no 2402 0.30168242577741 3348 1378119 SGTC_283 0987-0079 11.7 µM -0.519780220267801 0.276130733470578 no 2403 0.301608383514296 3406 411556 SGTC_1217 1183-1422 255 µM -0.519968386860691 0.27607473276983 no 2404 0.301542804579872 3398 2849664 SGTC_1127 asiatic acid 681.4 nM -0.520009490395959 0.276062500592461 no 2405 0.301528480223192 3286 470603 A kinase inhibitor which arrests cells at G2/M. SGTC_3261 9137475 49.47 µM -0.52026899998284 0.275985278165604 no 2406 0.301438049624327 3291 17027690 SGTC_1405 3909-7894 12 µM -0.521002709955398 0.275767005053703 no 2407 0.301182441777549 3397 7104060 SGTC_2085 5307070 144.047 µM -0.521148387044789 0.275723677329218 no 2408 0.3011317028175 3285 2840351 SGTC_1169 aniline yellow 25.8 µM -0.522026766458927 0.275462497978594 no 2409 0.300825847161535 3330 6051 A DNA damaging agent. SGTC_907 3448-6986 75.5 µM -0.522670602528748 0.275271135612739 no 2410 0.30060174959456 3462 590582 SGTC_2701 st077767 14.721 µM -0.523473198024744 0.275032678088374 no 2411 0.300322498826909 3361 5721188 SGTC_2362 9071156 126 µM -0.523482194575012 0.275030005718325 no 2412 0.300319369280059 3431 653133 SGTC_680 0417-1641 114 µM -0.524205148430977 0.274815298535229 no 2413 0.300067930195417 3258 2835990 SGTC_1289 0976-0073 69.1 µM -0.525092285735704 0.274551944115807 no 2414 0.29975951926853 3421 3391136 SGTC_1983 st071813 46.9 µM -0.525512235910114 0.274427321690916 no 2415 0.299613574784833 3373 11838595 SGTC_2398 5228213 48.84 µM -0.525789671271639 0.274345006604323 no 2416 0.29951717586692 3468 80771 YMR134W ERG29 SGTC_131 0141-0277 33.849 µM -0.526835047156809 0.274034953060007 no 2417 0.299154071290316 3417 1547771 SGTC_3157 9099274 49.47 µM -0.528064887630342 0.273670410016385 no 2418 0.298727150099699 3440 17217662 SGTC_2592 piperlongumine 83.33 µM -0.528118189994474 0.27365461582734 no 2419 0.298708653224393 3337 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_1724 st037281 8.293 µM -0.528657070994744 0.273494963655923 no 2420 0.298521681110558 3346 574124 YDL195W SEC31 SGTC_584 0986-0246 15.4 µM -0.528766475943154 0.273462556309996 no 2421 0.298483728073901 3455 53315 YDR232W HEM1 SGTC_971 1315-0384 26.7 µM -0.52877043535792 0.273461383509075 no 2422 0.298482354577433 3350 6769120 SGTC_462 ag-879 158 µM -0.528920665559866 0.27341688631806 no 2423 0.298430242775105 3414 6809654 Ag-879 is a 5-Lipoxygenase inhibitor. SGTC_1094 duloxetine 25.4 µM -0.530479039640633 0.272955517814614 no 2424 0.297889918900328 3329 60834 A selective serotonin reuptake inhibitor. SGTC_204 PMA1.184 62.41 µM -0.53052155420673 0.272942936465108 no 2425 0.297875184381905 3351 2252213 YGL008C PMA1 SGTC_692 k241-0027 77.8 µM -0.531276115933889 0.272719686618883 no 2426 0.29761372688094 3482 3600480 SGTC_1301 naphtanilide LB 4.81 µM -0.53220317930839 0.272445523348788 no 2427 0.297292640610248 3454 67238 An a1-adrenergic receptor antagonist or alpha blocker. SGTC_2648 atorvastatin 78.68 µM -0.532674731626531 0.272306122285899 no 2428 0.297129380304223 3437 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11 SGTC_3041 9091929 49.47 µM -0.532800759899528 0.272268871605186 no 2429 0.297085753881869 3496 25236887 SGTC_1755 st041960 45.185 µM -0.533521815852453 0.272055794912399 no 2430 0.296836206772935 3418 2257073 SGTC_2540 epiandrosterone 100 µM -0.534577354957469 0.271744025891454 no 2431 0.296471072970221 3477 441302 A steroid. SGTC_129 0088-0017 176.636 µM -0.535715172924485 0.271408153872396 no 2432 0.296077707822483 3420 182446 SGTC_2350 9023895 38.85 µM -0.537043603049386 0.271016277017961 no 2433 0.295618747777951 3433 2997209 SGTC_1398 3558-0053 112 µM -0.53901800124706 0.270434366440105 no 2434 0.294937216803697 3299 4532369 SGTC_2005 4024620 188 µM -0.542002066637833 0.269556065236263 no 2435 0.293908541098719 3433 236743 SGTC_1356 1502-0781 85.8 µM -0.54228674559409 0.269472350307297 no 2436 0.293810492499915 3352 567702 SGTC_335 4077-0256 27.6 µM -0.543177347455348 0.26921053711428 no 2437 0.293503850823195 3428 3121989 SGTC_507 nimesulide 162 µM -0.545299025234113 0.26858733495578 no 2438 0.292773937207265 3502 4495 A COX2 inhibitor. SGTC_228 caffeine 993.056 µM -0.545391369431265 0.268560227093661 no 2439 0.292742187495606 3442 2519 Caffeine is a phosphodiesterase inhibitor. SGTC_430 0958-0115 16.4 µM -0.545400428498016 0.268557567856808 no 2440 0.292739072900286 3333 6833180 SGTC_3246 9135460 32.98 µM -0.545443886523778 0.268544811187752 no 2441 0.292724131822037 3385 41446951 SGTC_2604 4'-hydroxychalcone 11.32 µM -0.546442770374968 0.268251682802234 no 2442 0.29238080841332 3465 5282362 SGTC_2640 pentamidine 10.38 µM -0.546988873886387 0.268091493579585 no 2443 0.29219318798903 3429 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_1665 st014639 11.4 µM -0.547055587045243 0.268071927826528 no 2444 0.292170271721656 3484 981133 YIL048W NEO1 SGTC_896 0964-0007 44.5 µM -0.548895248796068 0.267532671943872 no 2445 0.291538669473756 3436 6756758 SGTC_1810 st050138 53 µM -0.549252518631227 0.267428009706594 no 2446 0.291416083607281 3446 3444541 SGTC_3128 9127691 49.47 µM -0.549262385040203 0.267425119634067 no 2447 0.291412698601725 3419 41316314 SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM -0.550916352147445 0.266940861691867 no 2448 0.290845508672864 3425 16623 A steroid. SGTC_2115 tiliquinol 12.7705 µM -0.55099600552773 0.266917551504294 no 2449 0.290818206410048 3386 71208 A bioactive hydroxyquinoline. SGTC_324 1315-0088 19.6 µM -0.551075996639532 0.266894143516031 no 2450 0.290790789591097 3421 6787421 SGTC_1364 1653-0028 37.6 µM -0.551309860726301 0.266825713263864 no 2451 0.290710640001089 3410 5718652 SGTC_2866 9034245 58.44 µM -0.552916101828431 0.266355955666642 no 2452 0.290160430548228 3366 6462273 SGTC_1263 0774-1208 64.8 µM -0.553946022341841 0.266054967820593 no 2453 0.289807893621764 3512 906585 SGTC_2687 chenodiol 100 µM -0.555520917423033 0.265595047904011 no 2454 0.289269203378509 3469 5702181 A cholesterol synthesis inhibitor. SGTC_595 3909-8003 73.7 µM -0.557599458210702 0.264988665171127 no 2455 0.288558963263285 3477 699517 SGTC_1725 st036284 20.55 µM -0.559719878608204 0.264370790367622 no 2456 0.287835260562277 3511 707914 SGTC_734 2023-0417 80 µM -0.56014633676001 0.264246612260587 no 2457 0.287689813358352 3445 3935732 SGTC_397 arbidol 50 µM -0.560875429268968 0.26403438046786 no 2458 0.28744123059321 3499 131410 A RNA synthesis inhibitor. SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM -0.56093731764095 0.264016369360241 no 2459 0.287420134543674 3419 2724278 An inhibitor of dopamine biosynthesis. SGTC_423 5-fluorouracil 457 µM -0.562302774739263 0.263619145592302 no 2460 0.286954874074468 3367 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_2848 9016370 25.97 µM -0.562304510773289 0.263618640758515 no 2461 0.286954282772241 3507 7894410 SGTC_2337 9009472 200 µM -0.563430207509773 0.263291395217005 no 2462 0.286570986194864 3540 5742383 SGTC_19 0279-0214 38.434 µM -0.564240012636525 0.263056109278535 no 2463 0.28629540010465 3491 3566274 YBR002C RER2 SGTC_632 0781-2353 4.65 µM -0.565284575787116 0.26275277402245 no 2464 0.285940109076711 3474 6811515 YHR007C ERG11 SGTC_478 N-arachidonylglycine 10 µM -0.566930205236792 0.262275255733131 no 2465 0.285380800780169 3415 5283389 SGTC_3222 9128301 49.47 µM -0.570532213936824 0.261231601354799 no 2466 0.284158389742667 3404 4911358 SGTC_439 amiodarone 34.4 µM -0.570832487989446 0.261144695709197 no 2467 0.284056599132908 3358 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1 SGTC_2919 7978188 46.38 µM -0.572026633779442 0.260799231832303 no 2468 0.283651965541948 3507 2980291 SGTC_890 0929-0006 47.2 µM -0.57357897738188 0.260350493825771 no 2469 0.28312637054843 3383 1378169 SGTC_1361 1608-0041 5.61 µM -0.573791374830111 0.260289126765025 no 2470 0.283054493039871 3465 X1361 SGTC_2052 5265182 7.135 µM -0.573853764661789 0.260271102161558 no 2471 0.283033381335332 3463 1239884 SGTC_1208 2323-2347 50.3 µM -0.576704881874181 0.259448092921695 no 2472 0.282069417006064 3486 5412760 SGTC_1148 3909-7663 27.7 µM -0.577146176669714 0.259320828112699 no 2473 0.281920356388734 3534 4084526 SGTC_2954 9074818 52.69 µM -0.577873439344981 0.259111163559345 no 2474 0.281674784338162 3493 16648742 SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM -0.57945669740195 0.258655025026097 no 2475 0.281140528495192 3542 23847180 SGTC_2647 atorvastatin 60.16 µM -0.580375086031225 0.258390626804377 no 2476 0.280830851170524 3477 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7 SGTC_933 2914-0560 114 µM -0.581032217544004 0.258201528817817 no 2477 0.280609370070336 3527 463887 SGTC_2474 5321570 43.32 µM -0.581571111272212 0.258046508819841 no 2478 0.280427803197178 3461 2841384 SGTC_2581 avocatin a 64 µM -0.583794131524197 0.257407537905688 no 2479 0.279679413493681 3429 6710728 A skin care supplement. SGTC_981 1488-1094 54.9 µM -0.584703135911431 0.257146496429937 no 2480 0.279373672556846 3478 3449522 SGTC_1561 5-methoxyflavone 52.9 µM -0.585134682725925 0.257022616061092 no 2481 0.279228579922856 3479 94525 SGTC_400 oxethazaine 37.5 µM -0.585416731619604 0.256941667530607 no 2482 0.27913377056882 3464 4621 A local anesthetic. SGTC_1559 coumarin 343 70.1 µM -0.585417293343117 0.256941506328203 no 2483 0.279133581763829 3528 108770 A hepatotoxic, DNA x-linker. SGTC_104 0074-0074 590.992 µM -0.587120158007046 0.25645306326485 no 2484 0.278561505056312 3394 3943124 SGTC_1117 retinoic acid 1.10837 µM -0.587230360824912 0.256421469793702 no 2485 0.27852450214696 3544 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR). SGTC_1388 3346-4487 254 µM -0.588065123529863 0.256182221906951 no 2486 0.278244290832755 3494 3345614 SGTC_2595 hexamethylquercetagetin 100 µM -0.588518165157625 0.256052426263276 no 2487 0.278092272374924 3420 386331 SGTC_2151 5563267 85.4165 µM -0.588947186074714 0.255929544141861 no 2488 0.277948351444335 3444 5310824 SGTC_2237 6667747 47.222 µM -0.590816211490697 0.255394568642545 no 2489 0.277321785787238 3352 729940 YDL015C TSC13 SGTC_1135 dihydrocapsaicin 536.708 nM -0.591651028824806 0.255155805884919 no 2490 0.277042147820539 3482 107982 A Capsaicinoid. SGTC_1953 st076800 12.1 µM -0.595127567897365 0.254162751574993 no 2491 0.275879101163738 3442 297591 SGTC_2923 7992654 58.14 µM -0.596749527419109 0.253700142125449 no 2492 0.275337310174468 3497 2985126 SGTC_1785 bathophenanthroline 24 µM -0.597349282784061 0.253529194110279 no 2493 0.275137103679635 3431 72812 An iron chelator. SGTC_2971 9092186 9.93 µM -0.597914338554551 0.253368191890975 no 2494 0.274948545990582 3394 25236400 SGTC_2020 4017018 200 µM -0.598337563334691 0.253247637006734 no 2495 0.274807358663648 3510 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope. SGTC_275 trichlorophene 5.69 µM -0.598478712671672 0.25320743755761 no 2496 0.274760279346704 3524 62616 SGTC_997 3996-0078 137 µM -0.601714612325391 0.252286771688072 no 2497 0.273682060811457 3489 735687 SGTC_350 k064-0020 19.8 µM -0.601876238891821 0.252240832636206 no 2498 0.273628260937317 3529 2790705 SGTC_2255 7941087 197.44 µM -0.602443247473868 0.252079706909072 no 2499 0.273439564849551 3572 935561 SGTC_1924 st058459 75.1 µM -0.603239306654505 0.251853583979659 no 2500 0.273174751250696 3497 688683 SGTC_2358 9037157 4 µM -0.603610452961834 0.251748195399893 no 2501 0.273051330776551 3510 2388925 SGTC_2361 9034121 116 µM -0.604961970275347 0.251364623162672 no 2502 0.272602132816335 3477 6496917 SGTC_781 4335-2806 94.4 µM -0.605442973088476 0.251228185004775 no 2503 0.272442352545611 3571 845254 SGTC_1307 1187-1599 12.2 µM -0.605763439896729 0.251137305197812 no 2504 0.272335925200071 3428 1538471 SGTC_1245 0418-0076 17.2 µM -0.605865749800109 0.251108295233719 no 2505 0.272301952329547 3518 6790114 SGTC_2443 5493264 126.67 µM -0.606825791025043 0.250836162013832 no 2506 0.271983265124898 3529 5340055 SGTC_2834 9001755 58.44 µM -0.607681210675797 0.250593816415798 no 2507 0.271699463579945 3403 2989575 SGTC_2347 9049783 174.81 µM -0.608909149445749 0.250246150823316 no 2508 0.271292329665259 3540 6467988 YPL169C MEX67 SGTC_3094 9117742 49.47 µM -0.609318022710426 0.250130443559933 no 2509 0.27115683164579 3503 17149698 SGTC_1397 3532-0190 20.1 µM -0.609636263873381 0.250040403967202 no 2510 0.2710513918916 3459 5322280 SGTC_2741 miltefosine 3.04 µM -0.609924183247206 0.249958958101529 no 2511 0.270956015985204 3440 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis. SGTC_1069 diphenylcyclopropenone 8.49 µM -0.611509901821328 0.249510646667799 no 2512 0.270431032560173 3539 65057 A dermal irritant. YDR527W RBA50 SGTC_728 3030-5151 22.5 µM -0.6129239590622 0.249111227669392 no 2513 0.269963310160467 3558 3125388 SGTC_346 4513-0042 7.16 µM -0.613264584478905 0.249015064415035 no 2514 0.269850703309246 3550 2827372 SGTC_2705 st078069 42.8 µM -0.614251545521573 0.248736543262715 no 2515 0.269524558158967 3488 1530061 SGTC_2929 9013348 24.6 µM -0.61615361759587 0.248200245337626 no 2516 0.268896568687427 3524 2995952 SGTC_1733 st037357 54.9 µM -0.617239328020178 0.247894400989952 no 2517 0.268538439425801 3513 1272339 YGL099W LSG1 SGTC_732 3970-1727 52.7 µM -0.617352586216211 0.247862507775643 no 2518 0.268501094223532 3548 1275699 SGTC_2642 cholecalciferol 100 µM -0.617680583349374 0.247770156991161 no 2519 0.268392956788386 3523 9821465 A vitamin D precursor, similar to steriods. SGTC_280 3448-3607 3.04 µM -0.618555745116984 0.247523836613044 no 2520 0.268104531766949 3539 626179 SGTC_3114 9122766 49.47 µM -0.61860271438115 0.247510620486687 no 2521 0.268089056628442 3495 17176985 SGTC_1799 st045822 46.1415 µM -0.618849535766027 0.247441176530013 no 2522 0.268007742856956 3544 3674992 SGTC_745 0469-0705 296 µM -0.619092195006601 0.247372913757208 no 2523 0.267927812385001 3643 3486736 SGTC_673 1082-0474 110 µM -0.620327830829874 0.247025471689876 no 2524 0.267520987786438 3552 3098046 SGTC_2850 9015429 58.44 µM -0.620925515189247 0.246857505640867 no 2525 0.267324316151269 3505 6457570 SGTC_2820 7989630 71.43 µM -0.621432508869726 0.24671507414955 no 2526 0.267157544033432 3459 2984098 SGTC_1039 k821-0043 94 µM -0.621435516756129 0.246714229264933 no 2527 0.267156554766427 3547 15992768 SGTC_2967 9089538 49.85 µM -0.622003212397597 0.246554797092447 no 2528 0.266969877849244 3571 728216 SGTC_700 3453-2283 142 µM -0.622705735020085 0.246357576423177 no 2529 0.266738956652602 3607 565664 SGTC_178 4092-0806 87.505 µM -0.623428379986609 0.246154795024794 no 2530 0.266501526563141 3554 2169044 SGTC_3341 9147222 25.867 µM -0.623656908877295 0.24609068616981 no 2531 0.266426464041409 3537 1939759 SGTC_1521 st012942 49.4 µM -0.62475884956966 0.245781686205653 no 2532 0.266064671170682 3561 24207259 SGTC_2034 5197015 53.07 µM -0.626547123591238 0.245280672157339 no 2533 0.265478069059351 3579 780676 SGTC_471 1-acyl-paf 4 µM -0.627441961201571 0.245030175102151 no 2534 0.265184784705518 3515 16759367 SGTC_2097 5376186 200 µM -0.62853238895751 0.244725111493352 no 2535 0.264827617931917 3543 742755 SGTC_912 3474-0017 2.18 µM -0.629142450605781 0.244554526793256 no 2536 0.264627900560949 3587 3360550 SGTC_2865 9030313 51.95 µM -0.629740357224061 0.244387403034027 no 2537 0.264432236776197 3506 42562754 SGTC_622 1348-1566 26.3 µM -0.630810163097216 0.244088530083384 no 2538 0.264082328703585 3551 7340407 SGTC_3026 9090633 49.47 µM -0.631467780982152 0.24390490846322 no 2539 0.263867354659511 3533 25236842 SGTC_3323 9138564 53.9225 µM -0.631870578923906 0.243792475089523 no 2540 0.263735724846317 3587 43912313 YNL103W MET4 SGTC_207 4185-0010 4.486 µM -0.63448023754998 0.243064716812277 no 2541 0.26288373002789 3630 3761753 SGTC_2373 9071805 200 µM -0.635413894368004 0.242804632598324 no 2542 0.262579254262729 3598 10149009 SGTC_2630 antimycin a 100 µM -0.635454942607022 0.242793201448568 no 2543 0.262565872123117 3559 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain. SGTC_651 3253-0966 34.4 µM -0.636363231458003 0.242540334913109 no 2544 0.262269850143014 3559 781462 SGTC_2315 7733312 200 µM -0.637337212744513 0.242269338237359 no 2545 0.261952608288482 3544 726316 SGTC_2290 7904846 200 µM -0.637394353601756 0.242253444690591 no 2546 0.261934002675747 3568 2962154 SGTC_3166 9102297 49.47 µM -0.640080388058119 0.241506970832748 no 2547 0.261060169240902 3556 25237072 SGTC_3303 9125618 40.5795 µM -0.640138117464221 0.24149094102026 no 2548 0.261041404901646 3578 22695467 SGTC_1582 3',3',6'-trihydroxyflavone 74 µM -0.640206260335623 0.241472020428569 no 2549 0.261019256666807 3533 688803 SGTC_2193 5925765 200 µM -0.640865518076933 0.241289012100041 no 2550 0.260805030371461 3589 877370 SGTC_2567 aureobasidin a 60 nM -0.641058373860669 0.241235490061208 no 2551 0.26074237884582 3631 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1 SGTC_2551 apiole 73.87 µM -0.641551545263296 0.241098652690637 no 2552 0.26058220140249 3477 10659 A possible DNA adduct former. SGTC_1280 0880-0253 10.1 µM -0.641682537708723 0.241062314081038 no 2553 0.260539664801484 3552 6836607 SGTC_2989 9073649 71.4286 µM -0.642636588377167 0.240797740772237 no 2554 0.260229967995422 3586 21367202 SGTC_3095 9117207 49.47 µM -0.643386377451089 0.240589923358315 no 2555 0.259986710264664 3555 17015229 SGTC_3266 9136860 49.47 µM -0.644489792837586 0.240284269771571 no 2556 0.2596289372122 3520 4871271 YPR165W RHO1 SGTC_1741 st038134 10.228 µM -0.644540175832436 0.240270318391214 no 2557 0.259612607024541 3655 1272587 SGTC_2658 polymyxin b sulfate 77.05 µM -0.644819993374785 0.240192843119531 no 2558 0.259521921929107 3559 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides.  YIL048W NEO1 SGTC_1825 st052143 62.6 µM -0.645915186022096 0.23988973953622 no 2559 0.259167142122089 3614 674173 SGTC_970 1315-0089 19.5 µM -0.646381125911416 0.239760850122746 no 2560 0.25901628029361 3550 6811083 YLR033W RSC58 SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM -0.650946282560162 0.238500026399648 no 2561 0.257540581712711 3616 4213774 SGTC_2536 dehydroabietamide 32.04 µM -0.651465841711344 0.238356762832386 no 2562 0.257372910086891 3618 3983547 SGTC_2550 chrysin dimethyl ether 71.87 µM -0.652294655152431 0.238128322882597 no 2563 0.257105553684131 3478 88881 An O-methylated flavonoid and antioxidant. SGTC_3150 9097574 49.47 µM -0.652431151450312 0.238090712889063 no 2564 0.257061536932512 3575 17217476 SGTC_2212 7123476 200 µM -0.653386314971301 0.237827619625354 no 2565 0.256753629532018 3560 1085715 SGTC_2148 5546263 113.568 µM -0.653572366337261 0.237776391607243 no 2566 0.256693676189303 3575 792097 SGTC_1710 st031758 61.5 µM -0.653954196023789 0.23767127627725 no 2567 0.256570657915504 3633 5394341 SGTC_3270 9137563 49.47 µM -0.65493079317149 0.23740254120909 no 2568 0.256256156623048 3546 17015724 SGTC_2543 pimpinellin 60.67 µM -0.657179881783472 0.236784283371091 no 2569 0.255532629961905 3539 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo. SGTC_2309 7664088 163.95 µM -0.658727298207337 0.236359424734309 no 2570 0.255035450056737 3618 704922 SGTC_203 k066-0004 30.888 µM -0.658960417382303 0.236295455931445 no 2571 0.254960593503818 3670 6795412 SGTC_724 3910-0327 137 µM -0.659527322398553 0.236139934789681 no 2572 0.25477860345858 3610 2885483 SGTC_1860 st056228 74.6 µM -0.661178102635018 0.23568739147418 no 2573 0.254249051188542 3591 688679 SGTC_989 1501-0895 10.3 µM -0.661509718863444 0.235596540245548 no 2574 0.254142741976551 3606 2830112 SGTC_3118 9124250 49.47 µM -0.661755226595733 0.235529292175539 no 2575 0.254064052365186 3534 1504786 SGTC_3202 9113761 49.47 µM -0.662726437261885 0.235263367564065 no 2576 0.253752887343538 3637 4798415 SGTC_72 0744-0168 198.391 µM -0.663168411274482 0.235142406739817 no 2577 0.253611350097705 3559 677577 SGTC_2739 tacrine 100.86 µM -0.664838498042375 0.234685642454713 no 2578 0.25307689807316 3625 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders. SGTC_669 0108-0021 26.2 µM -0.665217165695176 0.23458214613202 no 2579 0.252955801376825 3714 17201 SGTC_1562 morin hydrate 59.1 µM -0.665363115603578 0.234542262275883 no 2580 0.252909135208722 3640 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase. SGTC_561 1550-0330 72.9 µM -0.665427971325175 0.234524540301268 no 2581 0.252888399630344 3581 6812934 SGTC_1567 st069303 68.4 µM -0.66602187638163 0.234362288837484 no 2582 0.252698558780175 3649 5581319 SGTC_1961 st076550 68.7 µM -0.669407703695677 0.233438487758991 no 2583 0.251617719377337 3605 1579337 SGTC_393 acivicin 6.25 µM -0.672622876850173 0.232563121652953 no 2584 0.250593621930845 3549 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1 SGTC_44 0929-0055 61.211 µM -0.673319825203745 0.232373610800395 no 2585 0.250371921392271 3581 1379590 SGTC_1495 4469-0029 237 µM -0.673693007303545 0.232272172237507 no 2586 0.250253254241586 3637 793680 SGTC_967 1306-0166 352 µM -0.674080118469892 0.232166973508047 no 2587 0.250130189346706 3618 4437607 SGTC_702 1488-0190 94 µM -0.674181496448723 0.232139428091905 no 2588 0.2500979660017 3631 949357 SGTC_2746 daunorubicin 9.88 µM -0.674375328551305 0.232086767024918 no 2589 0.250036361921159 3531 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_841 0251-0215 91.2 µM -0.674664565845864 0.232008198267533 no 2590 0.24994445095724 3662 3888614 SGTC_2014 4013930 200 µM -0.675133616781203 0.231880816209058 no 2591 0.249795438719246 3615 64556 SGTC_705 1124-0212 310 µM -0.676737804895751 0.231445454917234 no 2592 0.249286162812629 3636 9554485 SGTC_3306 9127676 59.7925 µM -0.677894296679329 0.231131877058153 no 2593 0.248919358206688 3640 41905287 SGTC_2042 p-Dimethylaminoacetophenone 200 µM -0.678217294434644 0.231044339955074 no 2594 0.248816964320338 3618 75037 A free radical scavenger. SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM -0.678328996483829 0.231014071377238 no 2595 0.248781558745539 3654 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis. SGTC_111 0083-0039 52.457 µM -0.679020521088914 0.230826734061961 no 2596 0.248562429772469 3566 759313 SGTC_1115 galangin 695.678 nM -0.67979488797153 0.230617055111629 no 2597 0.248317171995409 3685 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_2708 st078559 56 µM -0.680167392134638 0.230516228337685 no 2598 0.248199238307201 3576 17250902 SGTC_2712 st079126 47.7 µM -0.682199285636798 0.229966683817984 no 2599 0.247556473167157 3624 3152970 SGTC_2363 9053361 176 µM -0.682804756427161 0.229803070519031 no 2600 0.247365111864982 3687 6469797 YMR079W SEC14 SGTC_1210 3013-0140 750 nM -0.682955116871402 0.22976244948442 no 2601 0.247317602144322 3670 905973 SGTC_1742 st038235 28.8875 µM -0.683876148762036 0.229513713378813 no 2602 0.247026688157334 3644 564103 YBR002C RER2 SGTC_742 0kpi-0133 140 µM -0.685343023641415 0.22911787728549 no 2603 0.246563744312731 3659 2728852 SGTC_894 0960-0238 55.9 µM -0.687976661777462 0.228408152044468 no 2604 0.24573373913814 3631 6741907 YDL195W SEC31 SGTC_265 mycophenolic acid 32.932 µM -0.68799789649938 0.228402434636162 no 2605 0.245727053003757 3737 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1 SGTC_682 0kpi-0099 17 µM -0.68811701806469 0.228370362873256 no 2606 0.245689547245935 3668 1714895 YML126C ERG13 SGTC_3284 9108171 64.8615 µM -0.688629608368211 0.228232384208346 no 2607 0.245528191835642 3614 8687505 SGTC_3075 9116269 49.47 µM -0.689168559613215 0.228087360280216 no 2608 0.245358599827786 3671 17015205 YNL244C SUI1 SGTC_2406 ethylparaben 405.7 µM -0.689616113025926 0.227966969572632 no 2609 0.245217815876578 3597 8434 A possible steroid mimic. SGTC_1052 3253-3998 198 µM -0.690248440199772 0.227796936148203 no 2610 0.245018982906638 3649 5450317 SGTC_1266 0828-0227 32.9 µM -0.690662469784872 0.227685641845811 no 2611 0.244888839817833 3641 3913820 SGTC_2898 9056270 58.44 µM -0.690685717767291 0.227679393519015 no 2612 0.244881533317084 3606 19154699 SGTC_3313 9133968 57.047 µM -0.692094073806585 0.227301051785933 no 2613 0.244439126524856 3651 1494643 SGTC_2360 9040895 200 µM -0.69305494966508 0.227043124868391 no 2614 0.244137533972893 3635 4914414 SGTC_282 k297-0036 65.7 µM -0.693433666706924 0.226941511599468 no 2615 0.24401872024403 3671 5061378 SGTC_606 k015-0008 38.6 µM -0.694586709421317 0.226632297595415 no 2616 0.243657171838902 3711 1970475 SGTC_3207 9114163 49.47 µM -0.694947176515598 0.226535679153967 no 2617 0.243544203048884 3699 849233 SGTC_1691 st019933 84.6 µM -0.695024808245938 0.226514874038269 no 2618 0.243519877311496 3644 6176082 SGTC_2050 5263056 171 µM -0.698207425564471 0.225662869509728 no 2619 0.242523741668774 3677 763468 YGL055W OLE1 SGTC_2413 inermin 26.06 µM -0.69872410089632 0.225524723896849 no 2620 0.242362234594974 3731 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1 SGTC_2093 5331342 194.4 µM -0.698730614041059 0.225522982756046 no 2621 0.242360199028981 3680 33839 SGTC_2690 usnic acid 100 µM -0.699235298458881 0.225388090016899 no 2622 0.242202497183949 3716 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_3327 9140648 26.9345 µM -0.699589157246775 0.225293537407565 no 2623 0.242091957933984 3657 8029710 SGTC_2024 5144227 134 µM -0.699812830141911 0.225233782624656 no 2624 0.242022100575964 3692 3475211 SGTC_1015 4130-4525 82 µM -0.700011251336341 0.22518078141243 no 2625 0.24196013896288 3682 1363237 SGTC_2700 st077718 96.8 µM -0.701100605474886 0.224889924840183 no 2626 0.241620116254965 3674 904970 SGTC_2371 9071574 200 µM -0.701110450079959 0.22488729731089 no 2627 0.241617044618153 3658 45596039 SGTC_1726 st035556 14.5795 µM -0.703111740883456 0.224353513429006 no 2628 0.240993057926858 3763 5919439 SGTC_2300 7976697 71.57 µM -0.703794760169011 0.224171503403578 no 2629 0.240780298661948 3614 2236109 SGTC_569 4130-2812 160 µM -0.704035895697172 0.224107265978194 no 2630 0.24070520980256 3579 743552 SGTC_2955 9076254 12.21 µM -0.70481008018137 0.223901097380574 no 2631 0.24046421731089 3620 16459619 SGTC_3212 9128307 49.47 µM -0.705624500374791 0.223684330220956 no 2632 0.240210841911615 3655 27243542 SGTC_2340 7987427 183.45 µM -0.705869630108227 0.223619109535452 no 2633 0.240134607755891 3653 2239331 SGTC_1618 st003135 44.5 µM -0.707001721836608 0.223318038766471 no 2634 0.23978270388455 3622 1270615 SGTC_3201 9113999 49.47 µM -0.708391967501017 0.222948629796596 no 2635 0.239350939617099 3690 16649224 SGTC_253 dyclonine 31.25 µM -0.708948400942076 0.222800874740096 no 2636 0.239178248887211 3765 3180 An oral anasthetic. SGTC_2780 5215298 71.43 µM -0.709475136932092 0.222661056954729 no 2637 0.23901483760122 3680 2834131 SGTC_2616 abietic acid 100 µM -0.710151104712763 0.22248170010214 no 2638 0.238805219033016 3683 6708678 Abietic acid is an inhibitor of 5α-reductase. SGTC_652 0437-0092 114 µM -0.710591919755496 0.222364781529572 no 2639 0.238668575852917 3679 3091274 SGTC_176 1486-1328 72.834 µM -0.711425655425033 0.222143743412575 no 2640 0.238410252756384 3718 22310231 SGTC_3259 9138485 49.47 µM -0.711661942803464 0.2220811222506 no 2641 0.238337069771569 3799 17646153 SGTC_2186 6124449 200 µM -0.711916510183066 0.222013667778534 no 2642 0.238258238870323 3653 3834182 YLR033W RSC58 SGTC_610 4215-0184 155 µM -0.714285538849209 0.221386491144797 no 2643 0.237525316257107 3727 5605015 SGTC_1334 1486-0610 236 µM -0.717399798342618 0.220563565408319 no 2644 0.236563722004544 3744 3742339 SGTC_2591 skatole 100 µM -0.717644203700653 0.220499056907866 no 2645 0.236488347377661 3717 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite. SGTC_2920 7982904 15.77 µM -0.717842323452836 0.220446772993852 no 2646 0.236427256935367 3690 6456808 SGTC_206 4546-0025 72.014 µM -0.717880653724593 0.220436658433941 no 2647 0.236415438757094 3719 6620745 YIL048W NEO1 SGTC_2126 5251174 33.877 µM -0.717992799897043 0.220407066923733 no 2648 0.236380863164173 3717 790722 SGTC_1861 st057647 17.4 µM -0.718216015940064 0.220348174678895 no 2649 0.236312052096406 3730 688668 SGTC_1881 5652484 16 µM -0.719022286356312 0.220135527332543 no 2650 0.236063594075387 3665 2255129 SGTC_45 0kpi-0036 14.9 µM -0.719968604240625 0.219886093801903 no 2651 0.235772163112588 3686 2795021 SGTC_1508 1080-0625 72.9 µM -0.720462301736427 0.219756027829576 no 2652 0.235620201295566 3641 767111 SGTC_603 3794-0023 45.9 µM -0.723132145361319 0.219053415853325 no 2653 0.234799350883458 3708 3802260 SGTC_925 2064-1272 59.6 µM -0.72357046131911 0.218938189588956 no 2654 0.234664740719848 3710 6815817 SGTC_1308 1187-1617 41.4 µM -0.724342042635121 0.21873543791514 no 2655 0.23442788594387 3709 2882570 SGTC_1902 st060212 70.5 µM -0.725239969898282 0.21849962189027 no 2656 0.234152412972624 3732 688944 SGTC_3216 9129716 49.47 µM -0.725471073708001 0.218438952495104 no 2657 0.234081542197393 3697 8056934 SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM -0.726541498660331 0.218158070998645 no 2658 0.233753438443651 3717 688798 SGTC_535 2293-4129 48.2 µM -0.727432292416155 0.217924483829893 no 2659 0.233480589204856 3723 396118 YIL048W NEO1 SGTC_1044 1222-0021 1.78 µM -0.727915292604491 0.217797890092783 no 2660 0.233332720621109 3743 4306703 SGTC_2851 9015922 71.43 µM -0.727917586572383 0.217797288947934 no 2661 0.233332018455985 3710 2996893 SGTC_475 α-linolenic acid 10 µM -0.727983416606146 0.217780038292293 no 2662 0.233311868911646 3780 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_2514 salinomycin 42.74 µM -0.728385294136938 0.217674744018514 no 2663 0.233188881423431 3798 23682228 A polyether potassium ionophore. SGTC_382 3229-0966 23.2 µM -0.729093305581856 0.217489312338606 no 2664 0.232972294657817 3730 5722370 SGTC_1790 st045711 43.5 µM -0.729795028798578 0.217305617582434 no 2665 0.232757741804854 3721 585119 SGTC_1063 disulfiram 1.84 µM -0.731025948173745 0.216983608156433 no 2666 0.232381651861759 3728 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_2520 obtusaquinone 4.71 µM -0.731149489336651 0.216951304931301 no 2667 0.232343924287355 3753 5967872 SGTC_1648 st011736 69.8 µM -0.731416485167152 0.216881501045083 no 2668 0.232262399500771 3750 2855514 SGTC_1687 st020778 55.3625 µM -0.731745517298219 0.216795496134867 no 2669 0.232161954382365 3734 4259299 SGTC_2692 st077426 47.7 µM -0.732201019746213 0.216676466008244 no 2670 0.232022941011628 3700 25238571 SGTC_467 ro 31-8220 72.8 µM -0.732470501838828 0.216606063796431 no 2671 0.231940720436736 3671 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7 SGTC_2709 st078560 56 µM -0.732735946480097 0.216536729307505 no 2672 0.231859747576891 3716 17250903 SGTC_1059 3448-6867 171 µM -0.733372857130956 0.216370419786638 no 2673 0.231665524678327 3685 3934407 SGTC_1636 st007707 68.9 µM -0.733731196260024 0.216276883112658 no 2674 0.23155629071851 3736 403051 SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM -0.73414872151271 0.216167926716437 no 2675 0.231429051037516 3789 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_464 bw-b 70c 158 µM -0.735138563309171 0.215909746997831 no 2676 0.231127555282615 3766 5353454 SGTC_452 diindolylmethane 8 µM -0.735475560303484 0.215821889103141 no 2677 0.231024959457768 3697 3071 Inhibits expression of several cancer promoting factors. SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM -0.735716790302674 0.215759011180053 no 2678 0.230951534681426 3690 5711223 A potent inhibitor of glutathione S-transferases. SGTC_2021 4019055 173 µM -0.73659952839135 0.215529011196004 no 2679 0.230682960924692 3724 44827708 YER133W GLC7 SGTC_2997 9067075 71.4286 µM -0.738389174914713 0.21506315020658 no 2680 0.230138995409899 3767 27209819 SGTC_1040 k898-0338 155 µM -0.73873283151666 0.21497376028064 no 2681 0.230034622704841 3738 20969351 SGTC_2952 9073731 13.78 µM -0.739000460426556 0.214904161176286 no 2682 0.229953358887886 3781 16457353 SGTC_996 3970-0799 1.8 µM -0.739363501523374 0.214809770268141 no 2683 0.229843149453336 3793 6615648 YGL040C HEM2 SGTC_1113 artemisinin 1.17947 µM -0.739515871979826 0.214770161032968 no 2684 0.229796902725575 3744 2240 An anti-malaria and mitochondrial poison. SGTC_2190 6049624 200 µM -0.739971357681507 0.214651781231755 no 2685 0.229658687029374 3649 2265554 SGTC_2080 5212524 12.4 µM -0.740148994691365 0.214605624017315 no 2686 0.229604796264144 3695 260183 SGTC_2973 9094665 17.96 µM -0.740193834857918 0.214593973656955 no 2687 0.22959119396385 3775 25237061 YIL048W NEO1 SGTC_379 3970-0972 5.9 µM -0.741694915509295 0.2142041754711 no 2688 0.229136100550089 3742 2898042 YBL034C STU1 SGTC_465 cgp-37157 41 µM -0.742972870862537 0.213872642984989 no 2689 0.22874905269915 3680 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange. SGTC_1034 k072-0165 12.7 µM -0.7432131602357 0.213810339504782 no 2690 0.228676318494127 3728 5835461 SGTC_3048 9093155 49.47 µM -0.743664752113262 0.213693277012833 no 2691 0.228539659385275 3684 25236002 SGTC_3060 1327-0027 12.5 µM -0.74438558200851 0.213506499516811 no 2692 0.228321619520274 3691 16000455 YPR107C YTH1 SGTC_873 0591-4978 488 µM -0.74474742008539 0.213412777891635 no 2693 0.22821221320252 3782 3305145 SGTC_2879 9041815 71.43 µM -0.745356250337002 0.213255135629227 no 2694 0.228028192210674 3703 4942971 SGTC_2707 st078556 66.6 µM -0.745472370284495 0.213225076814385 no 2695 0.22799310404524 3731 17250899 SGTC_2684 capsaicin 100 µM -0.746840027134977 0.212871231066786 no 2696 0.227580065415841 3760 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_2460 5552655 174.22 µM -0.748938819684137 0.212328889960109 no 2697 0.226947040632959 3730 5401989 SGTC_1893 st059353 36.1 µM -0.749139976617651 0.212276952191279 no 2698 0.22688642112085 3778 3112488 SGTC_245 methotrexate 289.6 µM -0.749543432852267 0.212172804084315 no 2699 0.226764865373191 3745 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2 SGTC_3287 9117173 37.0625 µM -0.750152420743227 0.212015656667319 no 2700 0.226581455409242 3747 2789709 SGTC_2306 7482397 179.52 µM -0.751144899185484 0.211759696630876 no 2701 0.226282728432433 3743 891448 SGTC_605 1315-0399 119 µM -0.752231421041591 0.211479690261826 no 2702 0.225955950506063 3840 24020461 SGTC_493 zm226600 134 µM -0.75270255206817 0.211358343014389 no 2703 0.225814338010446 3765 5240098 A potassium channel opener. YCR052W RSC6 SGTC_26 0302-0163 425.158 µM -0.753143020860304 0.211244930208197 no 2704 0.225681987379157 3794 3100915 SGTC_1832 st054113 55 µM -0.759316724563695 0.209659068171825 no 2705 0.22383155762694 3721 1251267 SGTC_2342 7990637 118.86 µM -0.764040583743235 0.20845037488468 no 2706 0.222421529039954 3844 2033102 YER133W GLC7 SGTC_902 1120-0002 2.07 µM -0.76408191796753 0.208439816869956 no 2707 0.222409213553873 3759 3280475 SGTC_2763 lisinopril 49.32 µM -0.765180594741302 0.208159297111771 no 2708 0.222082006628996 3723 5362119 A lysine-analog of enalapril and an ACE inhibitor. SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM -0.765392758690093 0.208105152006763 no 2709 0.222018851823881 3783 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_861 0443-0273 110 µM -0.765463250234961 0.208087164116888 no 2710 0.221997870887724 3811 6149169 SGTC_2369 9071472 200 µM -0.766737003679425 0.207762288427386 no 2711 0.221618949021795 3862 17296037 SGTC_1252 0493-0875 34.8 µM -0.766820170282389 0.207741086891571 no 2712 0.221594221110279 3783 3960963 SGTC_768 0384-0033 77.3 µM -0.767400505251701 0.207593178556482 no 2713 0.221421714113619 3771 3965305 YMR134W ERG29 SGTC_3139 9095020 49.47 µM -0.767424500861704 0.207587064203088 no 2714 0.221414582971626 3550 25236292 SGTC_1149 3909-7961 23.3 µM -0.774191991184312 0.205866881779493 no 2715 0.219408631838748 3814 735261 SGTC_1736 st036774 51 µM -0.77507093397862 0.205644091432734 no 2716 0.219148872828468 3887 1272247 SGTC_2064 5220758 200 µM -0.775513309036519 0.205532014414808 no 2717 0.219018202105175 3844 788518 SGTC_262 fenpropimorph 62.5 µM -0.775952209751505 0.205420853479762 no 2718 0.21888860194338 3739 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_588 3970-1144 52.9 µM -0.776171259342516 0.20536538787397 no 2719 0.218823936710044 3738 1888707 SGTC_1828 st055811 49 µM -0.777890729220813 0.204930309492663 no 2720 0.218316717058791 3795 5877589 SGTC_169 k015-0017 16.025 µM -0.778402835173753 0.204800837038037 no 2721 0.218165783942816 3799 1840002 SGTC_2895 9054447 58.44 µM -0.779435727081202 0.204539845677806 no 2722 0.217861542486528 3824 2697450 SGTC_1447 4239-0816 81.9 µM -0.780704832362227 0.204219439007885 no 2723 0.217488058903979 3813 1341554 SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM -0.780783058702368 0.204199699255742 no 2724 0.217465049860492 3758 279621 SGTC_1872 amphotericin b 148 nM -0.781424084334933 0.204037984696655 no 2725 0.217276555232093 3822 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1 SGTC_2177 5811945 192 µM -0.784797328521816 0.203188258420942 no 2726 0.216286203345293 3841 5343475 SGTC_105 0111-0055 734.78 µM -0.78550534412755 0.203010176596559 no 2727 0.216078669116571 3832 5179370 SGTC_1818 st052136 56.3 µM -0.789679702035491 0.201962127907674 no 2728 0.214857424212222 3677 674169 SGTC_2576 guaiol 23.12 µM -0.792835533650105 0.201171952802046 no 2729 0.213936825410986 3823 227829 SGTC_807 1315-0151 48 µM -0.794315481232275 0.200802034520657 no 2730 0.213505896843929 3803 4011080 SGTC_818 4072-2707 53.5 µM -0.79468488308451 0.20070976488867 no 2731 0.213398413996408 3745 882871 SGTC_2348 9022543 33.42 µM -0.794867026592475 0.200664278237634 no 2732 0.21334542830314 3860 3162678 YDL140C RPO21 SGTC_633 0437-0093 97.7 µM -0.797271135351105 0.200064480882746 no 2733 0.212646790165035 3785 2831118 SGTC_1854 st056233 32.9 µM -0.798287156306779 0.1998113197247 no 2734 0.212351934807697 3741 5393174 SGTC_3205 9113483 49.47 µM -0.798404785593955 0.199782022576644 no 2735 0.212317813523247 3901 17018033 SGTC_436 n,n-dimethylsphingosine 3.3 µM -0.800318514058605 0.199305745973226 no 2736 0.211763139507567 3877 5282309 SGTC_1171 0368-0077 21.4 µM -0.800867613217348 0.199169215994959 no 2737 0.211604145601045 3803 3239779 SGTC_2158 5657123 3.6195 µM -0.802716674932002 0.198709873124289 no 2738 0.211069256358109 3789 2858827 SGTC_3081 9117243 49.47 µM -0.803080670149987 0.198619524945989 no 2739 0.210964054700618 3869 45595589 SGTC_2747 doxorubicin 7.63 µM -0.804854768076483 0.198179526350009 no 2740 0.210451746326961 3728 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_3347 9188721 44.724 µM -0.806192496391694 0.197848142364864 no 2741 0.210065932304319 3885 44118411 YKL104C | YBL026W GFA1 | LSM2 SGTC_1638 st008370 60.6 µM -0.808121821231015 0.19737079724036 no 2742 0.209510228475833 3818 24207134 SGTC_2964 9083345 53.42 µM -0.80889058022802 0.19718078847378 no 2743 0.209289043832601 3842 17741579 SGTC_537 1334-0398 209 µM -0.809293153723161 0.197081331377033 no 2744 0.209173271650031 3805 5846986 SGTC_3354 9151612 71.43 µM -0.809461821253839 0.197039670538798 no 2745 0.209124777410858 3879 27261949 SGTC_2103 5378138 10 µM -0.809879767587489 0.196936460868113 no 2746 0.209004640609773 3881 244142 SGTC_685 1278-0033 54.9 µM -0.810213456476159 0.196854081635137 no 2747 0.208908752422552 3871 3590572 SGTC_522 1273-0010 11.6 µM -0.811620740176387 0.196506888972529 no 2748 0.208504643343167 3973 5705015 SGTC_2462 5162487 171.77 µM -0.814296088059367 0.195847874702009 no 2749 0.207737675116755 3755 2259986 SGTC_1383 3049-0032 20.7 µM -0.814447467468317 0.195810625782903 no 2750 0.207694327570534 3925 712864 SGTC_2930 9013230 14.89 µM -0.815164405309075 0.195634272089241 no 2751 0.207489104764846 3882 2995857 SGTC_1129 3453-1384 223 µM -0.816515155038639 0.195302274271793 no 2752 0.207102779665828 3996 1084452 SGTC_3194 9111903 49.47 µM -0.816520102869517 0.19530105878487 no 2753 0.207101365329745 3850 17087251 SGTC_2083 5306046 65.942 µM -0.81677193427625 0.195239199809858 no 2754 0.207029386938757 3889 539837 SGTC_3299 9121982 43.1275 µM -0.817228037687534 0.195127194495986 no 2755 0.206899061260068 3928 17594604 YPL160W CDC60 SGTC_3090 9117696 49.47 µM -0.81724867036439 0.195122128653064 no 2756 0.206893166886418 3808 7923821 SGTC_846 0335-0850 148 µM -0.817598297365791 0.195036298554602 no 2757 0.206793300039785 3866 6819598 SGTC_1584 6-fluoro-dl-tryptophan 90 µM -0.818224988719605 0.194882509250481 no 2758 0.206614364452371 3895 94937 An inhibitor of serotonin biosynthesis. SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM -0.819350335580095 0.194606535661046 no 2759 0.206293280886485 3931 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_1805 st050013 60.3 µM -0.819600053443213 0.194545328544646 no 2760 0.206222071588343 3813 4037144 SGTC_1181 1222-0449 220 µM -0.820140912151545 0.19441280150159 no 2761 0.20606789081981 3879 658318 SGTC_3291 9121177 71.43 µM -0.821378304273835 0.194109809086366 no 2762 0.205715408806291 3876 17015612 SGTC_1937 st074714 47.2 µM -0.8220188513545 0.193953075417503 no 2763 0.205533083988483 3822 17250970 SGTC_3300 9124615 50.48 µM -0.825292863788805 0.19315317163247 no 2764 0.204602671156392 3913 24824903 SGTC_410 α-linolenic acid 100 µM -0.825773477803635 0.193035918193518 no 2765 0.204466300930044 3950 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_1759 st043059 70 µM -0.826113276984362 0.192953045007569 no 2766 0.204369918393201 3882 669426 SGTC_2856 9022925 19.48 µM -0.828724146546439 0.192317008522645 no 2767 0.20363025949962 3917 4944862 SGTC_3332 9141069 11.198 µM -0.829774188128463 0.192061568825052 no 2768 0.203333233580138 3817 17332883 SGTC_360 0957-0399 1.01 µM -0.836383414235931 0.190458537596873 no 2769 0.201469620101798 3913 6752301 YPR165W RHO1 SGTC_803 4488-1585 147 µM -0.836460271449769 0.190439944762035 no 2770 0.201448008937393 3904 747204 SGTC_566 0958-0068 16.5 µM -0.838588707316884 0.189925489287665 no 2771 0.20085007490775 3805 6815365 SGTC_2743 auranofin 4.32 µM -0.839926300052425 0.189602622855838 no 2772 0.200474855224156 3839 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold. SGTC_759 3486-0358 89.3 µM -0.843073948683821 0.188844180704131 no 2773 0.199593543755379 3866 875103 SGTC_2341 7987486 176.74 µM -0.84395439022913 0.188632368837578 no 2774 0.199347446472133 3924 1258686 SGTC_473 2-arachidonoylglycerol 10 µM -0.845688931223018 0.188215511051677 no 2775 0.198863149783365 3759 5282280 An endocannabinoid. SGTC_2913 7966556 36.57 µM -0.846360065131619 0.188054371798514 no 2776 0.198675954677749 3763 2976516 SGTC_2628 lathosterol 100 µM -0.848828574998712 0.187462415536732 no 2777 0.197988343668509 3991 6710616 SGTC_2918 7977171 22.06 µM -0.849032761133663 0.187413502696786 no 2778 0.197931531426503 3824 2236483 SGTC_887 0885-0007 9.62 µM -0.849115741226321 0.187393627049308 no 2779 0.197908446066368 3995 5719458 SGTC_1668 st014914 51.6 µM -0.85008726307703 0.187161022080498 no 2780 0.197638286205814 3913 2839556 SGTC_3129 9127257 49.47 µM -0.850221270957301 0.187128951490918 no 2781 0.197601038925371 3898 837894 SGTC_3007 9078383 71.4286 µM -0.851354926513063 0.186857782549661 no 2782 0.19728611095318 3901 6496995 SGTC_739 1486-1183 203 µM -0.852332227812617 0.186624208632562 no 2783 0.197014861818974 3881 4346692 SGTC_353 1988-1175 58.3 µM -0.853236853446235 0.186408165305791 no 2784 0.196763985035844 3758 2788357 SGTC_790 1575-0012 79.1 µM -0.85382267129905 0.186268342558407 no 2785 0.196601625400634 3995 378741 YLR208W SEC13 SGTC_2935 9038016 29.96 µM -0.854967714490873 0.185995231866708 no 2786 0.196284510707442 3924 6463195 SGTC_2010 4012422 159 µM -0.855535819627217 0.185859822109542 no 2787 0.19612729163927 3909 952393 SGTC_3328 9140624 29.0385 µM -0.856088404567669 0.185728170314821 no 2788 0.195974440968349 3952 4904392 SGTC_2219 9098279 200 µM -0.856872079010279 0.185541561328115 no 2789 0.195757792529991 3871 902349 SGTC_2447 5741742 33.78 µM -0.857667987414515 0.185352158326659 no 2790 0.195537910843274 3960 1776504 SGTC_1219 1469-0211 33.1 µM -0.858144539050428 0.185238810402183 no 2791 0.195406328088408 3927 6822282 SGTC_1180 1193-0155 285 µM -0.858213051406339 0.185222518261164 no 2792 0.195387415265519 3962 2921347 SGTC_1143 3454-2408 5.08 µM -0.858316951358041 0.185197812698175 no 2793 0.195358735825408 3841 X1143 SGTC_1921 5740136 50 µM -0.858323897125578 0.185196161191012 no 2794 0.195356818680642 3822 1774243 SGTC_376 3970-0862 59.1 µM -0.860593461047651 0.184657012900891 no 2795 0.194730994301407 3952 3135186 SGTC_519 k048-0011 62.8 µM -0.86078639732293 0.184611224802862 no 2796 0.194677849098563 3996 6836379 SGTC_2436 5633522 8.09 µM -0.86108837274899 0.184539573447082 no 2797 0.194594686266439 3885 5724242 SGTC_137 0438-0332 85.389 µM -0.862209785091119 0.184273641228265 no 2798 0.194286043017625 3909 2063393 YER012W | YPR107C PRE1 | YTH1 SGTC_2573 2',4'-dihydroxychalcone 15.04 µM -0.862741401132715 0.184147656928298 no 2799 0.194139832001836 3917 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_503 tyrphostin 8 294 µM -0.864225400380724 0.183796257204976 no 2800 0.193732040683555 3892 92970 A tyrosine kinase inhibitor. YOR207C RET1 SGTC_2651 TUB2.036 5 µM -0.864225831377725 0.183796155208879 no 2801 0.193731922324879 3943 15992207 YFL037W TUB2 SGTC_3231 9132313 49.47 µM -0.864284676688542 0.183782229707458 no 2802 0.193715762874441 3910 4905967 SGTC_761 k216-0224 480 µM -0.865197099682448 0.18356639265726 no 2803 0.193465308504539 3927 1340404 SGTC_2191 5911152 200 µM -0.865794677164934 0.18342511913104 no 2804 0.193301384349788 3928 2875902 SGTC_2279 7948423 32.93 µM -0.866006679209395 0.183375015937502 no 2805 0.193243249495109 3851 1247112 SGTC_259 usnic acid 108.925 µM -0.867074486374732 0.183122787032564 no 2806 0.192950599420534 4002 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_1938 st074717 56.4 µM -0.867360143085255 0.183055348188441 no 2807 0.192872356425312 3757 17250979 SGTC_2761 levamisole 97.89 µM -0.867855863121049 0.18293835363475 no 2808 0.192736621899207 3874 26879 An alkaline phosphatase inhibitor. SGTC_1498 4478-3555 97.6 µM -0.870691525747212 0.182270008028812 no 2809 0.191961303388543 3868 3437919 SGTC_1231 0242-0792 125 µM -0.871248159221979 0.18213899284534 no 2810 0.191809334743156 3929 3707635 SGTC_986 1493-0483 84 µM -0.87204891938596 0.181950620689588 no 2811 0.191590845375262 3853 40079 SGTC_2127 5253358 187.912 µM -0.873908346382862 0.181513676097046 no 2812 0.191084084503576 3855 20612 SGTC_3148 9097893 49.47 µM -0.874993837987196 0.181258901565544 no 2813 0.190788629263413 3939 17174100 SGTC_294 k038-0071 157 µM -0.876614819016766 0.180878860058683 no 2814 0.19034794368408 3940 24152826 SGTC_2262 9014885 67.46 µM -0.878039632755358 0.180545223012645 no 2815 0.189961105571768 3875 6457424 SGTC_1230 0170-0365 3.77 µM -0.879065877353515 0.180305154945506 no 2816 0.189682778933391 4010 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1 SGTC_731 3966-0296 387 µM -0.882941100223984 0.179400436592348 no 2817 0.188634047862716 3946 660956 SGTC_365 0121-0052 13.6 µM -0.888415597391208 0.178127221416287 no 2818 0.187158619211297 4009 3101739 SGTC_2257 7960413 200 µM -0.888597723680426 0.178084962062355 no 2819 0.187109657442407 3943 2974689 YIL048W NEO1 SGTC_1849 st056239 19.2 µM -0.88990717200649 0.17778131263037 no 2820 0.186757866285175 3970 5393181 SGTC_1011 4112-3381 17.4 µM -0.89090677524375 0.177549733487066 no 2821 0.18648959261782 4043 2877139 SGTC_2117 5521686 200 µM -0.892484245369915 0.177184666797956 no 2822 0.186066716757826 3917 803312 SGTC_1488 4013-0813 75.9 µM -0.894089861772098 0.176813573588656 no 2823 0.185636906617054 3901 2910057 SGTC_3252 9135871 49.47 µM -0.895952319678557 0.176383734594995 no 2824 0.185139114571274 3978 17682838 SGTC_2720 fluspirilene 36.88 µM -0.895974657621094 0.176378583208656 no 2825 0.185133149190597 3959 3396 An atypical antipsychotic. SGTC_2504 purpurogallin 52.29 µM -0.898904496247401 0.175703753826012 no 2826 0.184351766426843 3885 5281571 An antioxidant. SGTC_3186 9110464 49.47 µM -0.899064865856131 0.175666863193399 no 2827 0.184309055450521 3981 17018021 SGTC_1406 3909-7906 11.9 µM -0.900966764194215 0.175229734172256 no 2828 0.183802995573569 3973 X1406 SGTC_1964 st076914 61 µM -0.901699946380436 0.175061405229507 no 2829 0.183608140752556 4005 24208661 SGTC_3181 9108277 49.47 µM -0.90287435270416 0.174791990891023 no 2830 0.183296291954575 3896 17097298 SGTC_2041 5107442 45.335 µM -0.904032851184209 0.174526483889606 no 2831 0.182988991089887 4010 793005 SGTC_2839 9003951 25.97 µM -0.905917474010993 0.174095109836447 no 2832 0.182489767333162 4036 2990634 SGTC_1371 2421-0008 32.7 µM -0.906914733693794 0.173867120066168 no 2833 0.182225944554975 3955 2827552 SGTC_1800 st050079 29.0735 µM -0.907382568265146 0.17376023094149 no 2834 0.182102262168389 3876 3645560 SGTC_1932 st074806 40.9 µM -0.909022501602117 0.173385875156407 no 2835 0.181669124162838 4078 17251235 SGTC_3265 9137266 49.47 µM -0.910714802382285 0.173000103896768 no 2836 0.181222831355751 3864 17224265 SGTC_1509 1326-1131 80 µM -0.910833182066083 0.172973138936657 no 2837 0.181191638036278 3874 768313 SGTC_246 cycloheximide 667 µM -0.91221160099385 0.172659354743811 no 2838 0.180828669071152 3854 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells. SGTC_984 1492-0255 2.91 µM -0.91225020289803 0.172650572607854 no 2839 0.18081851087925 3955 1585198 SGTC_2053 5265679 138 µM -0.913724736610995 0.17231532166833 no 2840 0.180430751308808 3911 764595 SGTC_308 4092-1169 104 µM -0.915191433329028 0.171982264858384 no 2841 0.180045570569018 3925 2268590 YDL196W YDL196W SGTC_932 2857-0803 154 µM -0.915761451512806 0.17185293636729 no 2842 0.179896013034066 4075 674898 SGTC_205 1486-1330 71.903 µM -0.916718262030486 0.171635990210691 no 2843 0.17964514699223 3998 4118834 SGTC_132 0417-1715 25.805 µM -0.918528785186481 0.171225953217606 no 2844 0.179171048021628 3934 6769098 SGTC_913 3487-1245 167 µM -0.920697039970796 0.170735724126687 no 2845 0.178604311017746 3936 4016153 SGTC_1959 st077091 55.8 µM -0.92469255881166 0.16983471733546 no 2846 0.177562925594004 3988 821356 YKL052C ASK1 SGTC_2586 curcumin 80 µM -0.925643224325636 0.169620787975659 no 2847 0.177315711205964 3965 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40 SGTC_1480 1070-0044 41.2 µM -0.927034340840797 0.169308055116009 no 2848 0.17695435230957 4009 3124987 SGTC_2249 haloperidol 116.36 µM -0.927314908210952 0.169245026460454 no 2849 0.176881528063579 3979 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_751 0833-0568 350 µM -0.927508979199803 0.16920143778358 no 2850 0.176831165957743 4049 6954252 SGTC_2331 7980721 200 µM -0.927582521619675 0.169184921913309 no 2851 0.176812083808794 3977 2981221 SGTC_1246 0422-0085 105 µM -0.927756970248916 0.169145749059386 no 2852 0.176766824598227 4049 264295 SGTC_3058 9093861 49.47 µM -0.9292567097078 0.168809219287729 no 2853 0.176378032147378 4007 17217477 SGTC_398 bronopol 33.3 µM -0.931645289424819 0.168274129632405 no 2854 0.175759934709683 3911 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them. SGTC_957 1187-1561 14.1 µM -0.931816453311766 0.168235827433994 no 2855 0.175715695045826 3972 1538454 SGTC_1846 st056244 14.8 µM -0.932735553044778 0.168030251816577 no 2856 0.175478261725148 4042 5393182 SGTC_2038 4100038 30.985 µM -0.934460385333687 0.167644894060948 no 2857 0.175033230713978 4019 3596803 SGTC_1630 st005209 31.3 µM -0.936281631347529 0.167238614116898 no 2858 0.174564101539101 3958 3367314 SGTC_2046 4110841 106 µM -0.938030712989634 0.166849030413367 no 2859 0.174114313359929 4020 44119630 YMR134W ERG29 SGTC_1206 3978-0017 132 µM -0.940731332055438 0.166248655734013 no 2860 0.173421279132865 4124 3873677 SGTC_2119 5528445 120.635 µM -0.941686812547488 0.16603657742044 no 2861 0.173176504345987 4038 791935 SGTC_2175 5807670 165.306 µM -0.943157810518041 0.165710416807625 no 2862 0.172800094753941 4015 241186 SGTC_2891 9063876 19.48 µM -0.944574687707714 0.16539664820972 no 2863 0.172438027392355 4016 6472478 SGTC_4 0960-0234 25.671 µM -0.947403680860239 0.164771316094577 no 2864 0.17171655810164 4024 6821112 SGTC_3000 9075062 71.4286 µM -0.948462947893852 0.164537566019589 no 2865 0.171446913406623 3976 17057871 SGTC_1917 st066507 28.5 µM -0.949532125932789 0.164301846912747 no 2866 0.171175020369287 4001 3156428 SGTC_1 0258-0098 57.368 µM -0.956257649363473 0.162824110507698 no 2867 0.169471040327141 3976 6790032 YDR047W HEM12 SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM -0.958072493305483 0.162426837234227 no 2868 0.169013102361364 4051 6728940 SGTC_1884 5633444 25 µM -0.959248244886865 0.162169799681247 no 2869 0.168716850647889 4049 5724239 SGTC_908 3448-7491 47.7 µM -0.95932339235387 0.162153380288115 no 2870 0.168697927248189 4041 1203031 SGTC_2946 9065502 71.43 µM -0.961991595510771 0.161571091184657 no 2871 0.16802691285742 3851 16489101 SGTC_1456 k015-0012 13 µM -0.963668739231842 0.161205782207399 no 2872 0.167606015939948 4029 2989616 SGTC_394 menadione 8.33 µM -0.967478000221313 0.160378067088452 no 2873 0.166652566933701 4032 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_95 0471-0001 561.058 µM -0.969684777160665 0.159899828774794 no 2874 0.166101820322547 4059 4015405 SGTC_2084 5306078 60.6385 µM -0.97092771005186 0.159630879518709 no 2875 0.165792139097996 3990 679340 SGTC_2933 9026794 32.47 µM -0.971533179644077 0.159499973625974 no 2876 0.16564141944329 4020 17586027 SGTC_327 1273-0057 3.96 µM -0.972573716697217 0.159275167927738 no 2877 0.165382605414725 3935 3108138 SGTC_3064 1327-0027 10 µM -0.97398610125004 0.158970357549624 no 2878 0.165031720146467 3956 16000455 YPR107C YTH1 SGTC_2325 6158266 200 µM -0.974367627794086 0.158888084931491 no 2879 0.164937018478689 4093 3623240 SGTC_3106 9121286 49.47 µM -0.974424547858444 0.158875813046463 no 2880 0.164922892924616 4074 15943471 SGTC_2837 9008476 45.46 µM -0.974505540922658 0.158858352127733 no 2881 0.164902794650843 4090 2992805 SGTC_940 3232-1287 54.8 µM -0.976883557878538 0.158346247101733 no 2882 0.164313401331154 3984 1585493 YIL048W NEO1 SGTC_3164 9100705 49.47 µM -0.979498820001895 0.157784303368103 no 2883 0.163666785684537 4097 17174235 SGTC_1399 3562-5772 25 µM -0.980189115278291 0.157636197755557 no 2884 0.163496388207459 4022 23847490 SGTC_1158 4092-0494 91.8 µM -0.981713151951584 0.157309533122187 no 2885 0.16312059211099 4161 1148199 SGTC_756 0508-1999 28.3 µM -0.981831297944852 0.157284228107522 no 2886 0.163091483204079 4066 6753853 SGTC_85 0868-0259 160.055 µM -0.98610373726853 0.156370937065738 no 2887 0.162041104952329 3992 83173 SGTC_340 k038-0059 454 µM -0.98996145484192 0.155549304949726 no 2888 0.161096479755273 4059 23733424 SGTC_2116 5511452 16.8835 µM -0.991878218622962 0.155142125899654 no 2889 0.160628467765472 4119 870744 SGTC_3343 9148379 18.9835 µM -0.991928481204078 0.15513145807208 no 2890 0.160616207222409 4120 1955036 SGTC_1469 k284-2957 126 µM -0.992040638697754 0.155107655294442 no 2891 0.160588850867407 4059 23884841 SGTC_3310 9130229 44.1445 µM -0.993180946528496 0.1548657887952 no 2892 0.160310890954506 4132 7761258 SGTC_918 glabranin 770.725 nM -0.993251004415385 0.154850937202012 no 2893 0.160293823996128 4087 124049 Also referred to as licorice root. SGTC_1671 st016596 74.5 µM -0.998962487026467 0.153643323022845 no 2894 0.158906431929994 4142 2829167 SGTC_1128 3448-9350 235 µM -1.00086795635982 0.15324182873809 no 2895 0.158445325046319 4150 619386 SGTC_2621 lithochol-11-enic acid 100 µM -1.00087283730664 0.15324080118562 no 2896 0.15844414502806 4013 6708711 SGTC_3271 9137798 49.47 µM -1.00179930876768 0.1530458401438 no 2897 0.158220265576665 4025 6498326 SGTC_2420 aureobasidin a 50 nM -1.00363934032522 0.152659122802176 no 2898 0.157776242539341 4218 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1 SGTC_2685 mycophenolic acid 18.85 µM -1.00532960041488 0.152304454474818 no 2899 0.15736908318715 4057 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_791 1348-1292 225 µM -1.00596035895936 0.152172242275393 no 2900 0.157217319641579 4066 5437054 SGTC_3281 9140613 49.47 µM -1.00602614358531 0.152158457664377 no 2901 0.157201497087132 4099 16013766 SGTC_24 0417-1663 219 µM -1.00850244685501 0.151640172332 no 2902 0.156606656826284 4116 4329390 SGTC_3278 9139605 49.47 µM -1.00973718030667 0.151382184010492 no 2903 0.156310612123443 4124 7958859 SGTC_3047 9092122 49.47 µM -1.01271075236429 0.150762076918177 no 2904 0.155599170233078 4078 17173831 SGTC_3190 9110366 49.47 µM -1.01412448872543 0.150467851118272 no 2905 0.155261677083581 4102 17123768 SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM -1.01508267330774 0.150268652064357 no 2906 0.155033210104395 4045 4330530 SGTC_1183 1254-0324 198 µM -1.01583597892864 0.150112169190674 no 2907 0.154853749867388 4184 5799357 SGTC_123 0083-0120 66.675 µM -1.015934372724 0.150091738041753 no 2908 0.154830319618656 4074 16001701 SGTC_2004 4023728 41.89 µM -1.01726287655121 0.149816060077312 no 2909 0.154514195874144 4094 360084 YDR527W RBA50 SGTC_2863 9028737 58.44 µM -1.01781440836745 0.149701710927946 no 2910 0.154383081693675 4077 6460917 SGTC_2696 st077691 74.316 µM -1.01903626206716 0.149448591311737 no 2911 0.154092875756844 4173 757133 SGTC_2643 anethole 100 µM -1.01919104399598 0.149416547034328 no 2912 0.154056138832456 4094 637563 An anti-fungal, anti-helmenthic and channel blocker. SGTC_2297 7971671 152.32 µM -1.02186694386589 0.148863284435428 no 2913 0.153421939843329 4131 909016 SGTC_505 gw-5074 63.9 µM -1.02218073763598 0.148798494987341 no 2914 0.153347682914683 4152 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases. SGTC_2493 resveratrol 26.09 µM -1.02359076008294 0.148507598259464 no 2915 0.153014305659861 4028 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase. SGTC_2310 7668677 200 µM -1.02411472835312 0.148399597201725 no 2916 0.152890544277509 4138 2197143 SGTC_142 0335-0849 62.6745 µM -1.0243841372484 0.148344086725039 no 2917 0.152826935701834 4114 3889043 YPR107C YTH1 SGTC_1098 clofazimine 15.1 µM -1.02486314854699 0.148245422932524 no 2918 0.152713882463044 4171 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2 SGTC_2625 euphol 100 µM -1.03612370925013 0.145938687818174 no 2919 0.150072216253928 4161 6708538 A triterpene alcohol. SGTC_1773 st048542 73.5835 µM -1.03615861388136 0.145931575278572 no 2920 0.150064075467943 4067 3237138 SGTC_487 nimodipine 119 µM -1.03670757004046 0.145819744761259 no 2921 0.149936081482629 4075 4497 L-type voltage-gated calcium channels inhibitor SGTC_3297 9117502 71.43 µM -1.03834534055762 0.145486448932492 no 2922 0.149554653500332 4145 7453720 SGTC_1697 st025554 27.742 µM -1.04053010921065 0.145042633976201 no 2923 0.149046841493832 4121 1269519 SGTC_1604 st002052 72.4 µM -1.0431846298133 0.144504620866592 no 2924 0.148431395341288 4208 6254834 YHR062C RPP1 SGTC_2814 7977482 42.97 µM -1.04327696227555 0.144485931332122 no 2925 0.148410018845234 4192 6456762 SGTC_2092 5303694 80.6725 µM -1.04464779808474 0.14420864432308 no 2926 0.148092889835861 4141 1963699 SGTC_2491 paeonol 100 µM -1.04667557302646 0.143799132613392 no 2927 0.147624616729857 4043 11092 Increases levels of cortical cytochrome oxidase. SGTC_1894 3',6'-dihydroxyflavone 78.7 µM -1.04708407256017 0.143716730659446 no 2928 0.147530402280633 4128 688662 SGTC_414 piperonyl butoxide 100 µM -1.04710264763332 0.143712984479224 no 2929 0.147526119169083 4130 5794 A potent inhibitor of cytochrome P450. SGTC_1758 st042942 75.2445 µM -1.04750381287474 0.143632094427432 no 2930 0.147433637277823 4087 669317 SGTC_320 4092-0846 5.34 µM -1.04849180417601 0.143433009144441 no 2931 0.147206038197661 4105 1359356 SGTC_858 0438-0351 2.77 µM -1.05151357486351 0.142825263685548 no 2932 0.146511389017962 4110 2799119 SGTC_565 1418-0001 44.5 µM -1.05158794744413 0.142810327681019 no 2933 0.146494319926706 4222 2862145 SGTC_256 clotrimazole 625 nM -1.05253504786414 0.142620216900423 no 2934 0.146277069679712 4081 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C SGTC_358 0075-0058 9.45 µM -1.05267676469201 0.142591784910005 no 2935 0.146244580640851 3962 1069125 SGTC_3096 9117468 49.47 µM -1.05270457806439 0.142586205291968 no 2936 0.146238204904644 4036 41316311 SGTC_577 r071-0003 38.6 µM -1.05311904472283 0.142503076965036 no 2937 0.146143217684323 4143 4568517 YMR134W ERG29 SGTC_2783 7738165 71.43 µM -1.06061494798489 0.14100530281216 no 2938 0.144432463261392 4150 17201110 SGTC_2469 5655019 90.81 µM -1.06977191798991 0.139190163335933 no 2939 0.142360992742179 4212 2788239 SGTC_562 3772-2733 112 µM -1.07003772286197 0.139137712767619 no 2940 0.142301164622406 4152 2876874 YIL048W NEO1 SGTC_987 1497-1013 404 µM -1.07014802735096 0.139115950626252 no 2941 0.142276341968266 4166 1676435 SGTC_2479 5617353 43.85 µM -1.07112182703767 0.138923928705169 no 2942 0.142057327559536 4207 2731746 SGTC_2758 dehydroepiandrosterone 69.35 µM -1.07615269688469 0.137934775131081 no 2943 0.140929485591883 4181 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem] SGTC_649 1123-0311 367 µM -1.07819186987863 0.137535211068553 no 2944 0.140474069704334 4063 693629 YIL048W NEO1 SGTC_2157 5649910 96.377 µM -1.07840948008883 0.137492618321611 no 2945 0.140425529096136 4162 2858091 SGTC_3262 9137218 49.47 µM -1.07950253635249 0.137278811143937 no 2946 0.140181881865192 4068 17650664 SGTC_3153 9100258 49.47 µM -1.07996304967793 0.137188800496843 no 2947 0.140079317371415 4121 25236848 SGTC_1570 verbenone 133 µM -1.08183839852118 0.136822666475841 no 2948 0.139662170539545 4195 29025 A natural terpanoid with antifungal properties. SGTC_255 tunicamycin 200.472 nM -1.08266650500281 0.136661203761186 no 2949 0.139478238188225 4105 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_1922 5578187 25 µM -1.08310940358549 0.13657490168525 no 2950 0.13937993277262 4193 1350412 SGTC_617 3770-0098 35 µM -1.08575445680379 0.136060269446853 no 2951 0.13879382031585 4095 5962639 SGTC_2278 7948257 134.34 µM -1.0871340616731 0.135792375351078 no 2952 0.138488783240589 4170 1247028 SGTC_2114 5491910 81.25 µM -1.08721655712219 0.135776367694126 no 2953 0.138470557598302 4239 2849228 SGTC_2711 st079103 59.1 µM -1.08724497803766 0.135770853116333 no 2954 0.138464278970649 4132 54693780 SGTC_1284 0929-0043 16 µM -1.08753826133256 0.13571395562032 no 2955 0.138399499404341 4187 1239883 SGTC_1830 st055982 50.3 µM -1.08774889199335 0.135673102964642 no 2956 0.138352988658972 4143 455313 An antimicrobial agent. SGTC_1821 st053465 65.6 µM -1.09165409035264 0.134917199957603 no 2957 0.137492585754431 4190 675086 SGTC_2829 7992743 58.44 µM -1.09413762159688 0.134437985093233 no 2958 0.136947312225908 4186 16462845 SGTC_42 0133-0086 60.653 µM -1.09667414800941 0.133949752091798 no 2959 0.13639193067087 4071 162923 Model of phenazepam hydroxylation. SGTC_1225 1216-0074 20.6 µM -1.09677247227955 0.133930851106143 no 2960 0.136370433284732 4201 4241466 SGTC_567 1080-0542 68.4 µM -1.09724712098208 0.133839634629379 no 2961 0.136266689818761 4054 5950415 SGTC_3086 9117350 49.47 µM -1.09729880737353 0.133829704281898 no 2962 0.136255396040099 4123 2679265 SGTC_1071 trifluoperazine 6.31 µM -1.09846865737367 0.133605080040248 no 2963 0.135999948274666 4264 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. SGTC_224 benfluorex 43.875 µM -1.09925058954206 0.133455084978799 no 2964 0.13582938894144 4227 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis. SGTC_3224 9130643 49.47 µM -1.10046213505951 0.133222907668284 no 2965 0.13556540940637 4259 17644395 SGTC_198 3454-2873 16.191 µM -1.10283082609018 0.132769781421556 no 2966 0.135050319322 4182 710957 SGTC_2831 7999036 19.48 µM -1.10366160068857 0.132611107475109 no 2967 0.134869979334995 4235 2988270 SGTC_886 0866-0150 153 µM -1.10469540517674 0.132413838288344 no 2968 0.134645797531016 4261 271463 SGTC_1851 st056236 18.9 µM -1.11134005687294 0.131150742305383 no 2969 0.133211001766904 4208 5393171 SGTC_2402 5553605 200 µM -1.113619278553 0.13071940344261 no 2970 0.132721276130803 4301 6758546 SGTC_1507 4075-3230 155 µM -1.11594927466247 0.130279470317663 no 2971 0.132221924056432 4135 659771 SGTC_2884 9058502 51.95 µM -1.11923208754359 0.129661373172401 no 2972 0.131520569859705 4248 6471554 SGTC_2574 2',4'-dihydroxychalcone 14.64 µM -1.11940352352802 0.129629150626661 no 2973 0.131484014229317 4197 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_1433 4060-0023 7.6 µM -1.12002892004619 0.129511650173174 no 2974 0.131350719172958 4230 3840627 SGTC_7 0192-1582 4.227 µM -1.12260634052708 0.129028179281716 no 2975 0.130802360663055 4258 252616 SGTC_2415 st077333 57.7 µM -1.12448310664151 0.128676925060505 no 2976 0.13040406661165 4272 2766255 SGTC_945 3381-0768 11.3 µM -1.12643535243798 0.128312248756926 no 2977 0.129990644989197 4251 1126236 YIL048W NEO1 SGTC_2252 omeprazole 400 µM -1.13275575740197 0.127136532499686 no 2978 0.128658417760071 4195 4594 A proton pump inhibitor. SGTC_1446 4239-0190 62 µM -1.13342359550681 0.127012741131368 no 2979 0.12851820497659 4235 1340085 SGTC_3308 9128332 17.569 µM -1.13572876974892 0.126586095560957 no 2980 0.128035048041145 4238 17332805 YDL196W YDL196W SGTC_2859 9028643 45.46 µM -1.13587622658831 0.126558838007456 no 2981 0.128004184569774 4081 17151580 SGTC_2991 9074669 71.4286 µM -1.1360106272666 0.126533997460783 no 2982 0.127976058322494 4221 17333109 SGTC_3018 9082602 49.47 µM -1.13821783272993 0.126126537500827 no 2983 0.127514767065056 4170 17332089 SGTC_2129 girgensonine 121.053 µM -1.13902204275613 0.125978304338697 no 2984 0.127346980243361 4238 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_1417 3966-0327 90.4 µM -1.13918949411282 0.125947454747464 no 2985 0.12731206325817 4326 651118 SGTC_943 3253-1379 105 µM -1.14303009894128 0.125241345145277 no 2986 0.126513047227317 4251 668464 SGTC_1489 4065-0444 182 µM -1.1436605993392 0.125125689930466 no 2987 0.126382209744388 4224 2877968 SGTC_1023 4482-3888 16 µM -1.15058306871177 0.123860777458323 no 2988 0.124951900896928 4254 3303168 SGTC_1760 st045453 10.4495 µM -1.15207078466384 0.123590106244268 no 2989 0.124645993645683 4284 3323419 YIL048W NEO1 SGTC_3001 9076041 71.4286 µM -1.15462215190515 0.123126881921385 no 2990 0.124122595636779 4217 16004211 SGTC_654 1124-0271 80.9 µM -1.15516473244296 0.123028528520525 no 2991 0.124011486984636 4215 5403748 SGTC_183 3914-0051 30.55 µM -1.15563584815807 0.122943174207883 no 2992 0.123915069236116 4278 1596232 SGTC_1032 k061-1018 98.7 µM -1.15843668134433 0.122436590849816 no 2993 0.12334293860753 4327 4005393 SGTC_457 grayanotoxin iii 135 µM -1.16039635683774 0.122083018829186 no 2994 0.122943734687765 4097 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity. SGTC_97 0535-0701 19.132 µM -1.16087539757414 0.121996697662977 no 2995 0.122846287624581 4152 2832013 YGL099W LSG1 SGTC_847 0342-0274 5.54 µM -1.16138767013672 0.121904435698563 no 2996 0.12274214044538 4258 18097 SGTC_2881 9058953 51.95 µM -1.16150693555933 0.121882962641386 no 2997 0.12271790217027 4197 17122249 SGTC_2629 bisabolol 100 µM -1.16327049051397 0.121565754750862 no 2998 0.122359887249506 4296 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer. SGTC_799 1310-0557 151 µM -1.1668399571708 0.120925497179565 no 2999 0.121637503658729 4309 5354492 SGTC_1216 1165-0504 9.65 µM -1.16756282230164 0.120796125842769 no 3000 0.12149157693604 4271 6304004 SGTC_485 niflumic acid 177 µM -1.16829859574299 0.12066454437594 no 3001 0.121343170803904 4304 4488 A COX2 inhibitor. SGTC_892 0929-0076 29 µM -1.16886820463665 0.12056274813564 no 3002 0.121228367775428 4231 5751038 SGTC_869 0564-0080 44.1 µM -1.17023652531695 0.120318459249059 no 3003 0.120952898909076 4270 6843321 SGTC_1249 0481-0015 10.2 µM -1.17431085020717 0.119593127915541 no 3004 0.120135269436095 4195 4227577 SGTC_619 1652-1634 108 µM -1.17733134916633 0.119057398425614 no 3005 0.11953163951425 4230 5400454 SGTC_1658 st012944 20 µM -1.1798519503793 0.118611631822756 no 3006 0.119029551636342 4114 24207260 SGTC_70 0141-0289 43.283 µM -1.18818395296709 0.117146519480719 no 3007 0.11738047221071 4232 352408 SGTC_1367 1812-0510 76.9 µM -1.18833667310954 0.117119785123262 no 3008 0.117350397420279 4318 1142582 YDR527W RBA50 SGTC_1457 k015-0032 57.3 µM -1.18889428900316 0.117022208623607 no 3009 0.117240633876081 4261 4302660 SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM -1.19144659022899 0.116576319967111 no 3010 0.116739156038141 4215 1241132 A phosphatase inhibitor. SGTC_2096 5468907 200 µM -1.19150887619447 0.116565453650336 no 3011 0.116726937088455 4280 759785 SGTC_2073 5212005 126 µM -1.2029587801957 0.114580109122565 no 3012 0.114496135985064 4156 691789 SGTC_2639 lactacystin 53 µM -1.20308976304398 0.114557537574688 no 3013 0.114470793198054 4325 3870 A proteasome inhibitor. SGTC_2910 7948405 25.97 µM -1.20482082058605 0.114259531278954 no 3014 0.114136240253308 4210 2971328 SGTC_2745 rifampicin 24.3 µM -1.20568445955043 0.114111060057031 no 3015 0.113969589665186 4353 25141428 Inhibits bacterial DNA-dependent RNA polymerase. SGTC_1579 chlormadinone acetate 49.4 µM -1.20604942958848 0.114048358095581 no 3016 0.113899215995153 4335 45114258 A steroidal progestin. SGTC_1201 1889-3372 45.9 µM -1.2060864521139 0.114041998986091 no 3017 0.113892079027052 4165 5392199 SGTC_575 k072-0246 11.9 µM -1.21187303804275 0.11305117928885 no 3018 0.112780492201606 4368 6796779 SGTC_525 k781-2675 26.7 µM -1.21331575218095 0.112805107325019 no 3019 0.112504561332308 4255 3651118 YDL195W SEC31 SGTC_3168 9103419 49.47 µM -1.21384118547741 0.112715583525733 no 3020 0.112404187817973 4320 16649256 SGTC_1526 st051518 75 µM -1.21444878766222 0.112612122984745 no 3021 0.112288197373046 4282 673993 SGTC_3152 9099253 49.47 µM -1.21736769598784 0.112116046230033 no 3022 0.11173217408706 4190 25236131 SGTC_2275 7947463 200 µM -1.21823576956433 0.111968816479507 no 3023 0.111567195213216 4262 1225414 SGTC_1350 1495-0454 146 µM -1.22105381480228 0.111491814456036 no 3024 0.11103282244454 4342 1069057 SGTC_910 3454-3003 490 µM -1.22481235937263 0.110857882632034 no 3025 0.110322963578651 4212 820824 SGTC_1192 1488-0095 21.4 µM -1.22795139766328 0.110330421631482 no 3026 0.109732606735557 4341 915875 SGTC_286 k060-0067 22.9 µM -1.22887963439532 0.110174792858075 no 3027 0.109558469108878 4346 5985051 SGTC_1510 1123-0200 71.5 µM -1.22906938312307 0.110142998856816 no 3028 0.109522896603902 4329 5378812 YNL149C | YNL150W PGA2 | YNL150W SGTC_2473 5854593 8.94 µM -1.23246692965983 0.109574824875811 no 3029 0.108887356350275 4206 2872951 SGTC_112 phenothiazine 287.218 µM -1.23318297591393 0.10945534897381 no 3030 0.10875375270291 4272 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.  SGTC_57 miconazole 162.5 nM -1.23434095518621 0.109262332384107 no 3031 0.108537940421876 4173 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_635 k038-0028 24.7 µM -1.23436853243296 0.109257738682051 no 3032 0.108532804616407 4316 4035102 SGTC_2246 7293507 91.5585 µM -1.23449127810946 0.109237293905554 no 3033 0.108509947387848 4367 887656 SGTC_2547 epiafzelechin trimethyl ether 100 µM -1.23667502163347 0.108874024375709 no 3034 0.108103877774144 4218 6708630 An antioxidant. SGTC_65 0798-0905 34.986 µM -1.23964249218612 0.108381773673432 no 3035 0.107553828253414 4372 3602145 SGTC_296 1222-0039 74.9 µM -1.24727576006102 0.107122913039921 no 3036 0.106148201149989 4332 5984176 SGTC_2298 7976326 193.81 µM -1.24766470797797 0.107059052183996 no 3037 0.1060769353946 4249 2235818 SGTC_1345 1488-0192 31.4 µM -1.25020387039738 0.106642825050072 no 3038 0.10561254166976 4371 658348 SGTC_1866 st057638 64 µM -1.25434748992472 0.105966100895156 no 3039 0.104857864815109 4313 688802 SGTC_1222 0366-0074 1.18 µM -1.25488157199193 0.105879102405561 no 3040 0.104760877308337 4348 286520 SGTC_3338 9144300 39.5675 µM -1.25621120357845 0.105662738345824 no 3041 0.104519702908262 4336 4901274 SGTC_3329 9141233 27.5565 µM -1.25734781998757 0.10547803623258 no 3042 0.104313857551169 4297 4909101 YNL103W MET4 SGTC_2836 9010338 19.48 µM -1.25965681346791 0.105103540098913 no 3043 0.103896595459462 4305 2994051 SGTC_3040 9091894 49.47 µM -1.26123598223521 0.104847969112146 no 3044 0.103611919127386 4185 25236966 SGTC_2549 cedrol 20.94 µM -1.26389596671144 0.104418497901322 no 3045 0.103133684823569 4279 6708665 A sedative which affects the nervous system. SGTC_3125 9127534 49.47 µM -1.26597047185577 0.104084441803861 no 3046 0.102761827043574 4231 1639235 SGTC_3137 9097352 49.47 µM -1.2690574023247 0.103588790984673 no 3047 0.10221029583937 4361 44120435 SGTC_2986 9022445 71.43 µM -1.26920019106122 0.103565905728062 no 3048 0.102184836473475 4334 6459286 SGTC_1362 1611-0397 101 µM -1.26963841428571 0.103495693049284 no 3049 0.102106729666189 4308 27816 SGTC_435 c-PAF 6.7 µM -1.27004287524449 0.103430920466898 no 3050 0.102034679037076 4300 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase SGTC_1408 3909-7976 48.8 µM -1.2701708129861 0.103410437946787 no 3051 0.102011895925949 4396 24152374 SGTC_1123 mangostin 811.285 nM -1.27591850984998 0.102493280918148 no 3052 0.100992163571481 4341 5281650 An antioxidant. SGTC_2220 6782180 200 µM -1.28374966410345 0.101253206298675 no 3053 0.0996147805118126 4275 833803 SGTC_792 4534-1957 155 µM -1.2853973269928 0.100993694382131 no 3054 0.0993267374066295 4320 1717904 SGTC_1556 plumbagin 1.48 µM -1.2854139549941 0.100991077894907 no 3055 0.0993238336196637 4276 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_1583 clindamycin 39.6 µM -1.28662774009515 0.100800217043412 no 3056 0.0991120350594114 4321 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis. SGTC_1615 st002656 86.5 µM -1.28688790103276 0.100759342458435 no 3057 0.0990666814821525 4362 1584458 SGTC_1054 3429-0080 167 µM -1.28690608270623 0.100756486338745 no 3058 0.0990635124581097 4371 1162877 SGTC_718 1130-0073 349 µM -1.28994134268958 0.100280511208292 no 3059 0.0985355124759091 4370 6740020 SGTC_1976 st070609 63.5 µM -1.29510046194393 0.0994752515630242 no 3060 0.0976427877945266 4310 682556 SGTC_2794 7785382 27.27 µM -1.30161638449482 0.0984649830590324 no 3061 0.0965237779946537 4358 2205081 SGTC_3059 1327-0034 3 µM -1.30364968005965 0.0981512716422926 no 3062 0.0961765268197449 4211 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_1009 4106-0057 9.87 µM -1.30386453126674 0.0981181656798591 no 3063 0.0961398877224868 4369 2928005 SGTC_299 1273-0059 1.44 µM -1.3040302225119 0.0980926402585716 no 3064 0.0961116390017108 4166 2848077 SGTC_2055 5235184 200 µM -1.30584763680129 0.0978129793727329 no 3065 0.0958021882961485 4404 2836034 SGTC_1087 pterostilbene 9.05 µM -1.31371913387533 0.0966084719424491 no 3066 0.0944703697641911 4372 5281727 Similar to reservatol, lowers cholesterol. SGTC_865 0488-0499 301 µM -1.31452594220576 0.0964856313485111 no 3067 0.094334636916953 4326 9634651 SGTC_1541 2',3',6-trimethoxyflavone 64 µM -1.32025250862543 0.0956170296273144 no 3068 0.0933753629752404 4473 688801 SGTC_110 0850-0284 111.64 µM -1.32057468162982 0.095568334162856 no 3069 0.0933216097257468 4256 3906265 SGTC_822 1487-0950 154 µM -1.32358387846945 0.0951143843108138 no 3070 0.0928206411234473 4391 1958375 SGTC_1010 4112-3296 15.2 µM -1.32477355711127 0.0949353550465519 no 3071 0.0926231338574261 4413 704384 SGTC_992 3909-8734 162 µM -1.32641751647093 0.0946883718940132 no 3072 0.0923507199458426 4396 4288319 SGTC_2450 5739737 12.93 µM -1.32710676782476 0.0945849620130499 no 3073 0.0922366834421428 4400 2262825 SGTC_871 0574-0004 149 µM -1.32816195247113 0.094426811684701 no 3074 0.0920623053202216 4342 9551173 SGTC_403 arphamenine a 50 µM -1.33222821065336 0.0938191871788087 no 3075 0.0913926045443959 4390 5487158 An arginine aminopeptidase inhibitor. SGTC_2959 9079155 11 µM -1.33284280047049 0.0937276001338974 no 3076 0.0912916983695177 4403 16189457 SGTC_2056 5235370 200 µM -1.3364746560331 0.0931877230926518 no 3077 0.0906970894527594 4307 5511916 SGTC_762 1165-0429 115 µM -1.33917069172492 0.0927884446715791 no 3078 0.0902575556335877 4385 5967793 SGTC_2518 prenyletin 46.28 µM -1.34063934529252 0.0925714724940537 no 3079 0.0900187881685685 4403 3873459 A coumarin with calcium channel inhibitory activity. SGTC_3076 9116187 49.47 µM -1.34467859220757 0.0919766685414615 no 3080 0.0893645254339104 4382 27241210 SGTC_1410 3909-8106 77.9 µM -1.3448617884988 0.0919497590073113 no 3081 0.0893349360323104 4444 1039210 SGTC_3183 9108214 49.47 µM -1.34637066474764 0.0917283433040462 no 3082 0.0890915033426751 4386 4974831 SGTC_1200 1643-0193 18.4 µM -1.3520462037626 0.0908990394841092 no 3083 0.0881802675549283 4420 5403974 SGTC_1835 st008666 49.2 µM -1.3523171871437 0.0908595832683185 no 3084 0.0881369342591466 4342 690455 SGTC_716 1683-5115 658 µM -1.36311872522425 0.0892971684735835 no 3085 0.0864225481178847 4391 723597 SGTC_1018 4259-0013 28.1 µM -1.37055072831784 0.0882338147791272 no 3086 0.0852575257373464 4459 6801262 SGTC_2118 5526350 200 µM -1.37172843248261 0.0880661815276799 no 3087 0.0850739968934876 4436 743594 SGTC_2736 butenafine 14.65 µM -1.37335434004919 0.0878351418018564 no 3088 0.0848211085460063 4365 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_2796 7949634 45.45 µM -1.37404864076998 0.0877366202744595 no 3089 0.0847132911763379 4381 2971588 SGTC_2650 prasterone 100 µM -1.37406108475523 0.087734855220708 no 3090 0.0847113596984051 4421 16759247 A steroid and weak partial agonist of the androgen receptor. SGTC_1795 st049545 62.3 µM -1.3747172001974 0.0876418293796801 no 3091 0.0846095683130168 4365 5291882 SGTC_1064 honokiol 6.76 µM -1.377024779191 0.0873152390834986 no 3092 0.0842522934628486 4443 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis. SGTC_3219 9131112 49.47 µM -1.37850477088906 0.0871062554765644 no 3093 0.0840237479392651 4287 17612988 YMR079W SEC14 SGTC_1343 1487-0095 224 µM -1.38072585492773 0.0867933265243133 no 3094 0.0836816342494905 4423 4560101 YGL055W OLE1 SGTC_2199 6590217 200 µM -1.38260761959456 0.0865288623123239 no 3095 0.0833926057253699 4342 703109 SGTC_2819 7996655 46.38 µM -1.38867468556766 0.0856802957852269 no 3096 0.0824658476293443 4394 6456960 SGTC_953 1188-0045 9.7 µM -1.3914371181681 0.0852960003630002 no 3097 0.0820464577421785 4423 6144426 SGTC_2627 acetyl isogambogic acid 100 µM -1.39640561437958 0.0846080609288615 no 3098 0.0812961926883153 4439 6857789 A caspase activator and apoptosis inducer. SGTC_3336 9143619 71.43 µM -1.39932437498292 0.0842058736813485 no 3099 0.0808578667048643 4437 45595730 SGTC_1885 st057546 99.9 µM -1.40268720227736 0.0837442778118776 no 3100 0.0803550676150957 4464 702008 SGTC_18 0111-0177 500 nM -1.40281346382937 0.083726983715608 no 3101 0.0803362355165387 4516 721752 SGTC_3011 9081274 71.4286 µM -1.4045563699427 0.0834885312108001 no 3102 0.0800766191324262 4435 6625322 SGTC_2765 myclobutanil 7.74 µM -1.40630471332809 0.0832498479351693 no 3103 0.0798168305725348 4445 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11 SGTC_2346 9031566 143.75 µM -1.40652672470855 0.0832195757594835 no 3104 0.0797838872849405 4401 4771086 SGTC_1295 1013-0063 9.78 µM -1.40770946305172 0.0830584439449996 no 3105 0.0796085592827899 4458 6826038 SGTC_2439 5492030 7.2 µM -1.40845453941969 0.0829570580826593 no 3106 0.0794982596332541 4445 5722370 SGTC_2130 NSC 7 2.4545 µM -1.41230984975424 0.0824339354503994 no 3107 0.0789293737276757 4496 21448 SGTC_3003 9075612 71.4286 µM -1.41349933642481 0.0822730377760751 no 3108 0.0787544781748556 4453 6501993 SGTC_167 3672-0051 66.205 µM -1.41383709392179 0.0822273936506451 no 3109 0.0787048697471023 4359 3237971 SGTC_458 nppb 133 µM -1.41402145556288 0.0822024872970571 no 3110 0.0786778014622853 4483 4549 A chloride channel blocker. SGTC_1557 sumaresinolic acid 42.3 µM -1.41666134896719 0.0818464735992342 no 3111 0.0782909812823232 4410 9982268 A natural terpine and antifungal of unknown mechanisn. SGTC_2445 5742597 35.57 µM -1.41915340339387 0.0815114647781591 no 3112 0.0779271487139624 4459 1774255 SGTC_3253 9135987 49.47 µM -1.42274509951847 0.0810304508673896 no 3113 0.0774050307980213 4450 4182430 SGTC_1328 1441-0025 69.2 µM -1.4249631246943 0.0807344761707076 no 3114 0.0770839303714247 4433 4562601 SGTC_946 3434-1334 87.4 µM -1.42547220501643 0.0806666594986766 no 3115 0.0770103745502508 4420 4047976 SGTC_668 1682-0499 62.6 µM -1.42895708538558 0.0802035791160613 no 3116 0.0765082841593638 4436 682214 SGTC_2638 epoxomicin 18 µM -1.42984669106199 0.0800856884466821 no 3117 0.0763805124786796 4427 9915668 A protesome inhibitor. SGTC_1030 k029-0042 36.7 µM -1.43110397798642 0.0799192960765598 no 3118 0.0762002086909004 4434 6080581 SGTC_293 4049-0273 38.5 µM -1.4313739364583 0.0798836032407553 no 3119 0.0761615370269976 4316 1380311 SGTC_190 3970-0790 3.722 µM -1.43222197990874 0.0797715567239017 no 3120 0.0760401516188486 4419 2832352 SGTC_3071 9117417 49.47 µM -1.43486481004722 0.0794231390578935 no 3121 0.0756628125820082 4402 45595590 YGL055W OLE1 SGTC_2035 5154463 94.595 µM -1.43616969478585 0.0792515348022518 no 3122 0.0754770300802656 4470 2769623 SGTC_1540 guanosine 70.6 µM -1.43742757814376 0.0790863775203407 no 3123 0.0752982686564861 4386 6802 Guanosine is a purine nucleoside SGTC_1999 st074831 12.5 µM -1.43955491441136 0.0788076563534637 no 3124 0.0749966815052881 4440 17112523 SGTC_1653 st012112 65 µM -1.43972370375341 0.0787855736749493 no 3125 0.0749727921675748 4456 720429 SGTC_1715 st032160 10.2275 µM -1.43995423004827 0.0787554215370374 no 3126 0.0749401743634757 4370 5289825 SGTC_2600 tangeritin 87.95 µM -1.44353918457596 0.0782876450038204 no 3127 0.074434321254194 4371 68077 A bioactive flavone. SGTC_1411 3909-8223 150 µM -1.4442208500366 0.078198937974919 no 3128 0.0743384308663164 4480 X1411 SGTC_2605 digitonin 300 nM -1.44773786332501 0.077742470185503 no 3129 0.0738451881935211 4461 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_998 3996-0085 177 µM -1.45080922315331 0.0773454999335332 no 3130 0.0734164953495516 4495 715391 SGTC_1988 st071872 53.4 µM -1.45842302754748 0.0763680642875699 no 3131 0.0723619886297176 4491 16414116 SGTC_10 0279-0212 42.575 µM -1.4589084017131 0.0763060736527014 no 3132 0.0722951601913941 4476 39851 YBR002C RER2 SGTC_2667 digitoxin 100 µM -1.46021856163419 0.0761389348641229 no 3133 0.0721150077741551 4433 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_683 panaxydol 45 µM -1.46077744206494 0.0760677226167105 no 3134 0.0720382641871046 4488 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis. SGTC_3127 9126946 49.47 µM -1.46115519424965 0.0760196183599826 no 3135 0.0719864279964408 4422 27243249 SGTC_1274 0865-0114 173 µM -1.46196043209524 0.0759171539256396 no 3136 0.0718760265129678 4465 870624 SGTC_2466 5983409 37.09 µM -1.46414920979683 0.0756391690780265 no 3137 0.0715765920626805 4461 2879657 SGTC_3289 9119912 71.43 µM -1.46665945232174 0.0753213121774615 no 3138 0.0712343591651464 4470 17014829 SGTC_2176 5809774 33.9695 µM -1.46887652410052 0.0750414253889293 no 3139 0.0709331415868107 4389 2870539 SGTC_2139 5578692 56.4705 µM -1.47537335123233 0.0742258226295267 no 3140 0.0700560978986914 4457 650991 YMR113W FOL3 SGTC_2204 7233102 200 µM -1.47575621467977 0.0741779705529654 no 3141 0.0700046744560425 4450 2172480 SGTC_152 4469-0003 551.229 µM -1.47633362674018 0.0741058474439724 no 3142 0.0699271755877443 4460 697280 SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM -1.4831661543666 0.0732564758410907 no 3143 0.069015135565888 4405 4000243 SGTC_1585 2',4'-dihydroxychalcone 10.4 µM -1.48389910144457 0.0731658051623601 no 3144 0.0689178451518485 4504 5357218 A potent inhibitor of glutathione S-transferases. SGTC_2149 5554786 194.827 µM -1.48546056947982 0.0729729270048539 no 3145 0.0687109305434788 4512 745063 YPR165W RHO1 SGTC_1644 st010134 20.9 µM -1.48759547544977 0.0727098458437073 no 3146 0.0684288036918499 4466 3818134 SGTC_287 k060-0039 29.6 µM -1.48766356042429 0.0727014678038276 no 3147 0.0684198210213064 4520 5861974 SGTC_3213 9129884 49.47 µM -1.48871695946449 0.0725719383884057 no 3148 0.0682809585825366 4467 17190742 SGTC_3105 9121040 49.47 µM -1.50001861428157 0.0711933496204392 no 3149 0.066804790425522 4458 41448907 SGTC_2902 5787006 60.46 µM -1.50174116257126 0.0709850088551604 no 3150 0.0665819844252103 4464 591003 SGTC_2164 5685496 200 µM -1.50326394436993 0.0708012199347421 no 3151 0.0663854969482894 4424 759046 SGTC_934 2950-0684 338 µM -1.51010265574297 0.0699803410599259 no 3152 0.0655086159813994 4513 1121253 SGTC_378 3970-0959 8.33 µM -1.51131034097604 0.0698361414357063 no 3153 0.0653547002492963 4512 6615653 SGTC_193 1273-0060 1.558 µM -1.51477274383216 0.0694239923330958 no 3154 0.0649149825843406 4349 2847393 YHR072W ERG7 SGTC_2045 5106652 78.05 µM -1.51850651263368 0.0689816430801297 no 3155 0.0644433794823818 4504 673349 SGTC_323 4013-0906 34.3 µM -1.52367888242644 0.0683724522852444 no 3156 0.0637944736106621 4529 2910086 SGTC_2513 baicalein 25.65 µM -1.52394636718214 0.0683410617443159 no 3157 0.0637610547112821 4486 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2 SGTC_1089 terbinafine 2.25 µM -1.52525221471781 0.0681879742978125 no 3158 0.0635981007648771 4515 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_1698 5-fluorocytosine 1.055 µM -1.52800660161766 0.0678659393992031 no 3159 0.0632554494455461 4525 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_717 1532-0246 73.2 µM -1.52957949392968 0.0676825690049594 no 3160 0.0630604242118733 4494 9561992 SGTC_2027 5150920 200 µM -1.53223052439823 0.0673743739969765 no 3161 0.0627327792836303 4465 786715 SGTC_135 0933-0004 26.348 µM -1.53928351773597 0.0665597113696615 no 3162 0.0618675479911204 4448 21230617 YGL099W LSG1 SGTC_2454 5-benzylidenerhodanine 10.36 µM -1.54016976411784 0.0664578862070851 no 3163 0.061759488983736 4560 1273210 SGTC_2225 6654152 15.4 µM -1.54239068590339 0.0662032434937371 no 3164 0.0614893417850134 4463 97582 YGR029W | YLR033W ERV1 | RSC58 SGTC_49 0717-0965 32.132 µM -1.54663439499098 0.065718777824725 no 3165 0.0609757154824134 4568 5889349 YGL099W LSG1 SGTC_988 1497-1057 103 µM -1.55123320539516 0.0651968811921713 no 3166 0.0604229036469049 4510 3533044 SGTC_938 3126-1755 342 µM -1.55333699877679 0.0649592065713079 no 3167 0.0601713227553933 4504 1777771 SGTC_431 k089-0097 107 µM -1.55357092780931 0.0649328202031181 no 3168 0.0601433992268191 4242 5499420 SGTC_1346 1488-2224 62.4 µM -1.55556407543588 0.0647083375294813 no 3169 0.059905893429546 4537 3722427 SGTC_2006 4011487 200 µM -1.55640910963817 0.0646133457996344 no 3170 0.0598054201844978 4487 45595294 SGTC_3177 9107506 49.47 µM -1.55817109818169 0.0644156260826194 no 3171 0.0595963471325425 4497 8897194 SGTC_2862 9027634 71.43 µM -1.55833676365573 0.0643970603076436 no 3172 0.0595767191868714 4484 5012562 SGTC_559 1550-0661 158 µM -1.55885786005742 0.0643386892568725 no 3173 0.0595150130277647 4562 5830875 SGTC_1586 deoxycorticosterone acetate 53.7 µM -1.56399596980411 0.0637653388242731 no 3174 0.0589092574421915 4528 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE. SGTC_1797 st048695 56.8 µM -1.5681306590054 0.0633068504127704 no 3175 0.0584253213820636 4492 592262 YIL048W NEO1 SGTC_676 falcarinol 140 µM -1.57255159549702 0.0628194640389781 no 3176 0.0579113416354419 4548 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer. SGTC_2 0422-0095 29 µM -1.57511178163365 0.0625385559526279 no 3177 0.0576153225226023 4449 6790840 SGTC_1088 bifonazole 369 nM -1.57511388958075 0.0625383250691363 no 3178 0.0576150792844399 4528 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase. SGTC_1114 scopoletin 1.73284 µM -1.57779509359832 0.0622451903185881 no 3179 0.0573063456864697 4563 5280460 A coumarin with genotoxic properties. SGTC_2759 disulfiram 3.38 µM -1.5778406792064 0.0622402157473183 no 3180 0.0573011079005219 4444 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_1380 2291-0730 164 µM -1.5784881330406 0.0621695952288704 no 3181 0.0572267561260595 4548 2999191 SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM -1.58147643281073 0.0618444585236554 no 3182 0.0568845716886839 4466 17037758 SGTC_1820 st053765 18.6 µM -1.58600178610988 0.0613546141167536 no 3183 0.0563694521948707 4562 3690829 SGTC_1103 duloxetine 36.1 µM -1.5901810532762 0.0609049287277049 no 3184 0.0558969999905663 4593 60835 A selective serotonin reuptake inhibitor. SGTC_164 4100-3994 89.624 µM -1.59295024362647 0.0606083885431591 no 3185 0.0555856767864374 4514 4615967 SGTC_1017 4239-0030 168 µM -1.59720331433756 0.0601551471500069 no 3186 0.0551101970876804 4554 1149593 SGTC_884 0851-0618 334 µM -1.59921002056524 0.0599422198427477 no 3187 0.0548869722697293 4560 9642473 SGTC_2766 oltipraz 83.91 µM -1.60283640444286 0.0595589296984604 no 3188 0.0544853885963262 4515 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40 SGTC_1530 rhein 70.4 µM -1.60519715308473 0.0593104447171718 no 3189 0.0542252119036006 4630 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death. SGTC_1713 st033146 12.748 µM -1.60833674740939 0.0589812411011973 no 3190 0.0538807233117538 4518 674619 SGTC_658 3253-0951 102 µM -1.60895070300075 0.0589170323970954 no 3191 0.0538135606964284 4560 1184878 SGTC_1101 ebselen 5.29 µM -1.61166200663808 0.0586341345133792 no 3192 0.0535177547888042 4560 3194 A potent scavenger of hydrogen peroxide and hydroperoxides. SGTC_1704 st028805 70.8 µM -1.61239114245979 0.0585582385889856 no 3193 0.053438425556446 4604 2876101 SGTC_563 tetrahydrosecaminediol 614 µM -1.61267089776596 0.0585291392736817 no 3194 0.0534080132105451 4599 334274 A psychoactive constituent of the cannabis plant. SGTC_3069 9117009 49.47 µM -1.61929908803285 0.0578430103972853 no 3195 0.0526914634082762 4555 41904981 SGTC_1955 wogonin 32.4 µM -1.61947718949363 0.0578246615211348 no 3196 0.0526723152624118 4528 5281703 A flavanone. SGTC_816 0325-0417 81.3 µM -1.62218600925407 0.0575461494827075 no 3197 0.052381763212507 4586 68101 SGTC_2075 5212009 200 µM -1.64319568143656 0.0554216843799977 no 3198 0.0501712265619497 4499 780898 SGTC_1174 0739-0097 51.1 µM -1.64560029545671 0.0551825352947831 no 3199 0.0499230391425304 4583 728447 SGTC_1254 0550-0035 264 µM -1.64655780488354 0.0550875341337449 no 3200 0.0498244847130948 4550 15121435 SGTC_2985 9022375 71.43 µM -1.65220526765859 0.0545298360893778 no 3201 0.0492463564896459 4577 4939335 SGTC_881 0833-0569 170 µM -1.65607717310721 0.0541500647226617 no 3202 0.0488530956948959 4592 5418700 SGTC_1086 cerivastatin 2.18 µM -1.65795533656531 0.0539666026979919 no 3203 0.0486632408163196 4588 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7 SGTC_798 1287-0182 476 µM -1.67143267469105 0.0526645103171139 no 3204 0.0473181232448547 4615 1649755 SGTC_2545 solidagenone 89.61 µM -1.67744016167279 0.052092197390954 no 3205 0.0467282207144846 4536 6708572 An anti ulcer agent SGTC_3024 9090631 49.47 µM -1.67850609947953 0.051991167109576 no 3206 0.0466241703662471 4565 25236383 SGTC_1620 st003704 16.5 µM -1.67856507964125 0.0519855814798396 no 3207 0.0466184185150532 4592 2834414 SGTC_3236 9132701 49.47 µM -1.68221213922254 0.0516411173291375 no 3208 0.0462638555077401 4595 24282524 SGTC_3195 9113082 49.47 µM -1.68235970461195 0.051627218092133 no 3209 0.0462495550735107 4559 17018038 SGTC_2476 5806916 10.51 µM -1.68957836876193 0.0509509134282148 no 3210 0.0455543235865465 4510 2870194 SGTC_2717 st081029 62.2815 µM -1.6974555044848 0.0502209842844613 no 3211 0.0448052882813979 4567 5292846 SGTC_1306 1185-0270 9.02 µM -1.70168640723946 0.0498323854300499 no 3212 0.0444070849232897 4600 1548076 SGTC_2226 7298446 200 µM -1.70195814533863 0.0498075091001254 no 3213 0.0443816072968033 4613 3283010 SGTC_199 4063-0024 41.6 µM -1.7116965399225 0.0489225257957581 no 3214 0.0434763033010842 4632 306215 SGTC_1145 3546-0597 10.2 µM -1.71599689658916 0.0485357481406766 no 3215 0.0430813052161252 4583 875334 SGTC_609 0986-0026 86.3 µM -1.719622687192 0.0482115447212682 no 3216 0.0427505247418294 4592 2848610 SGTC_392 N-ethylmaleimide 8.33 µM -1.72637572927307 0.0476123354582589 no 3217 0.0421399196417177 4572 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides. SGTC_1248 0469-0687 58.6 µM -1.73049472740771 0.0472497880560869 no 3218 0.0417709612256604 4559 4017482 SGTC_443 clozapine 122 µM -1.73984694936879 0.0464348349364321 no 3219 0.0409429480121616 4595 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_2641 levomentholum 100 µM -1.74178938380215 0.0462669944341271 no 3220 0.0407726525111371 4618 16666 SGTC_501 nsc-95397 161 µM -1.74933942027042 0.0456192376767648 no 3221 0.040116182862701 4598 262093 SGTC_3188 9110789 49.47 µM -1.75059298957967 0.0455123966342779 no 3222 0.0400080218525903 4574 849217 SGTC_1672 st016598 6.51 µM -1.75083607368444 0.0454917020157031 no 3223 0.0399870754214648 4577 4665860 YNL267W PIK1 SGTC_1186 1319-0216 26 µM -1.75145160652021 0.0454393333442076 no 3224 0.0399340751297606 4643 4565136 SGTC_1005 4092-0690 4.4 µM -1.7527257486651 0.0453310851662789 no 3225 0.0398245468648117 4614 1529343 SGTC_217 ketoconazole 989 nM -1.76319269505544 0.0444496688277483 no 3226 0.0389339977063504 4415 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4 SGTC_2335 9018011 154.17 µM -1.77333596173514 0.0436087356704597 no 3227 0.0380865267241021 4598 6458208 SGTC_2670 beta-carotene 100 µM -1.77873891735684 0.0431660691007791 no 3228 0.0376412878143379 4616 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.) SGTC_1413 3910-0535 34.4 µM -1.78373367614378 0.0427600814364552 no 3229 0.0372334756234524 4642 2876951 SGTC_598 3937-0236 20.2 µM -1.79237245915549 0.0420651873536631 no 3230 0.0365366616987118 4674 1379313 SGTC_2205 7238770 200 µM -1.7967212970452 0.0417188463288165 no 3231 0.0361899381044324 4655 279867 SGTC_1414 3917-0015 5.4 µM -1.80207496473602 0.0412956563521936 no 3232 0.0357668059816552 4626 6618702 SGTC_1053 3366-3204 134 µM -1.80565864985704 0.0410143268922757 no 3233 0.0354858376801168 4629 3632071 YPR165W RHO1 SGTC_634 1611-4317 11.2 µM -1.80571465399782 0.041009942774732 no 3234 0.0354814612429769 4648 2843522 SGTC_444 curcumin 90.4 µM -1.81969369122149 0.0399274660686138 no 3235 0.0344028323010654 4535 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. SGTC_763 3453-1109 128 µM -1.8289803468347 0.0392212702880251 no 3236 0.0337012762333166 4662 1560353 SGTC_941 3237-0776 460 µM -1.83015308568655 0.0391328177578185 no 3237 0.0336135253781438 4625 760008 SGTC_38 0929-0051 58.268 µM -1.83933450329183 0.0384459179451365 no 3238 0.0329330005698698 4584 1379719 SGTC_446 go6976 132 µM -1.84207524385949 0.0382427871410048 no 3239 0.0327320722068803 4641 3501 A protein kinase C inhibitor. SGTC_645 0845-0943 5.41 µM -1.86477202536053 0.0365940334229614 no 3240 0.0311066830312772 4664 1885106 SGTC_1815 st051655 58.2 µM -1.86633776422972 0.0364824719682677 no 3241 0.030997062213483 4627 5984156 SGTC_1603 st002045 67.8 µM -1.87220534091929 0.0360668706665731 no 3242 0.0305891002374899 4648 5887985 SGTC_3142 9086498 49.47 µM -1.8831625378576 0.0353011536410977 no 3243 0.0298391720984269 4532 25236367 SGTC_1974 st069448 26.9 µM -1.88594170749043 0.0351090726596623 no 3244 0.0296514051786483 4645 6323587 YNR016C ACC1 SGTC_2230 bromochlorosalicylanilide 954.5 nM -1.88607937034008 0.0350995804932197 no 3245 0.0296421299137386 4690 77254 SGTC_1132 3456-3614 2.5 µM -1.91056933330923 0.0334441484336131 no 3246 0.0280299742342257 4623 3125502 SGTC_564 3555-0129 330 µM -1.91097868338353 0.0334170337546326 no 3247 0.028003660170277 4616 563260 SGTC_1501 4491-0275 38.4 µM -1.91205430089563 0.0333458728666755 no 3248 0.0279346147777944 4685 5104718 SGTC_862 0452-0056 10.2 µM -1.91290224699805 0.0332898623065335 no 3249 0.0278802839363794 4631 1575396 YLR359W | YHR072W ADE13 | ERG7 SGTC_845 0330-0138 4.51 µM -1.91806622156946 0.0329504296261716 no 3250 0.0275513074315627 4640 9039800 SGTC_1451 4152-0210 104 µM -1.92323916854732 0.0326132721072728 no 3251 0.0272250101418321 4681 659563 SGTC_2288 7946289 167.31 µM -1.92578770852935 0.0324482148533828 no 3252 0.0270654434238921 4649 1246052 SGTC_1946 st076057 65.1 µM -1.92926899544561 0.0322238621328307 no 3253 0.0268487383392893 4660 953009 SGTC_2748 diazoxide 86.69 µM -1.93045597091272 0.0321476604075045 no 3254 0.0267751828004635 4736 3019 A potassium channel activatior. SGTC_2847 9005661 71.43 µM -1.93601292078489 0.0317928899237946 no 3255 0.0264330592501218 4696 2991449 SGTC_3214 9129694 49.47 µM -1.93625972806538 0.0317772084065766 no 3256 0.0264179492417319 4644 17158655 SGTC_2608 thymoquinone 42.66 µM -1.93721193253663 0.0317167675898973 no 3257 0.0263597211144283 4622 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC). SGTC_3136 9095672 49.47 µM -1.93998748128037 0.031541132443214 no 3258 0.0261906056518036 4549 17217380 SGTC_592 k241-0073 46.5 µM -1.94100274372071 0.0314770883587676 no 3259 0.0261289722867293 4702 4230158 SGTC_1649 st011737 51.3 µM -1.946760843865 0.0311158906143958 no 3260 0.0257817066695177 4680 1761035 SGTC_1989 st071868 50.2 µM -1.95752181367711 0.0304500617712612 no 3261 0.0251430748500145 4664 16414057 SGTC_2295 7971645 200 µM -1.96020097700452 0.0302861379762636 no 3262 0.0249861521753839 4694 2978226 YKL099C UTP11 SGTC_2399 5884133 200 µM -1.96223254506841 0.0301623252161104 no 3263 0.0248677082572901 4608 722445 SGTC_1793 st048256 72.231 µM -1.96419788910298 0.0300429480264652 no 3264 0.0247535737636211 4680 672022 SGTC_154 3389-1638 511.116 µM -1.96485592839003 0.030003065635777 no 3265 0.0247154574195995 4677 5238686 SGTC_2751 anetholtrithion 17.25 µM -1.9691750337608 0.0297423820955166 no 3266 0.0244664974011202 4631 2194 A chloretic substance that stimulates the liver to produce bile. SGTC_2594 a-mangostin 100 µM -1.98262794303249 0.028942435757144 no 3267 0.0237045018745768 4655 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis. SGTC_2744 captopril 92.04 µM -1.98326992637006 0.0289047131041151 no 3268 0.0236686433749431 4715 44093 angiotensin-converting enzyme (ACE) inhibitor  SGTC_99 0109-0120 622.8 µM -1.98641751947675 0.0287203528472257 no 3269 0.0234934914526511 4683 759414 SGTC_2067 5224629 34.075 µM -1.9898201381812 0.0285221561656825 no 3270 0.0233053761148368 4660 2835000 SGTC_2201 6605497 169.863 µM -2.00701018981547 0.0275381813625522 no 3271 0.0223742890007357 4669 670741 SGTC_182 3448-4371 550.524 µM -2.01484082880877 0.0270994208824828 no 3272 0.0219606647579446 4634 3491403 SGTC_1096 rimcazole 32.2 µM -2.02082318899831 0.026768165845331 no 3273 0.0216490357233466 4670 18528119 A dopamine reuptake inhibitor. SGTC_848 0368-0089 85.6 µM -2.02375312321805 0.026607167266866 no 3274 0.0214977798194894 4687 762535 SGTC_2324 6149169 200 µM -2.02392550208538 0.0265977203749353 no 3275 0.0214889087668773 4674 2888231 SGTC_1445 4239-0156 97.7 µM -2.0336275629166 0.0260705167478881 no 3276 0.0209945803157931 4706 4008346 SGTC_699 0375-0592 111 µM -2.03568252530551 0.0259599803716913 no 3277 0.020891122467227 4738 762578 SGTC_1699 st031318 29.054 µM -2.04600586345306 0.0254106036687377 no 3278 0.0203778968958893 4732 5340658 SGTC_1264 0783-0040 158 µM -2.04724440061247 0.0253453515385705 no 3279 0.0203170469635742 4630 2855798 SGTC_502 l-744,832 89.3 µM -2.05178377319975 0.0251073942685488 no 3280 0.0200953404927893 4701 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.  SGTC_2426 5582046 32.21 µM -2.06323812478235 0.0245152606503634 no 3281 0.0195450047807186 4678 2251934 SGTC_2289 7946404 165.07 µM -2.065665984863 0.0243912693339206 no 3282 0.0194300146105721 4674 1246120 YPR165W RHO1 SGTC_506 n9-isopropylolomoucine 153 µM -2.06931308645093 0.0242060008500254 no 3283 0.0192583582049378 4695 6610355 SGTC_50 0929-0078 56.389 µM -2.08438353039726 0.0234529256488997 no 3284 0.0185626473589563 4597 1377751 SGTC_2162 5663267 200 µM -2.10883959426089 0.0222728324251808 no 3285 0.0174792148369003 4710 6456493 SGTC_2597 laccaic acid a 100 µM -2.11466094472546 0.0219994338993481 no 3286 0.0172294276498258 4652 5491415 A textile dye. SGTC_2282 7944268 200 µM -2.13051068425028 0.0212693752692748 no 3287 0.0165647373397186 4689 2970414 SGTC_3240 9133527 49.47 µM -2.13800082644747 0.0209315633140757 no 3288 0.0162583380794312 4708 17617455 SGTC_2742 clothiapine 36.27 µM -2.16257330120497 0.0198550390896862 no 3289 0.0152870067987541 4735 16351 An atypical antipsychotic. YIL048W NEO1 SGTC_1370 2001-0092 44.6 µM -2.16545309736967 0.0197320062912031 no 3290 0.0151765017764571 4670 790957 SGTC_130 0136-0219 337.655 µM -2.1686445387056 0.019596415785276 no 3291 0.0150548405112132 4660 234244 SGTC_2753 fluvastatin 17.09 µM -2.18673556645576 0.0188426724756966 no 3292 0.0143809168066689 4689 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5 SGTC_2515 chrysin 20.77 µM -2.19163650061728 0.01864277772894 no 3293 0.0142028820793127 4728 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor. SGTC_1886 st057356 49.9 µM -2.19977861518726 0.0183146754849233 no 3294 0.0139113029623583 4717 24207747 SGTC_80 0159-0065 512.242 µM -2.2004292695836 0.0182886696979037 no 3295 0.0138882265386898 4710 1548079 SGTC_3061 glucosamine 200 µM -2.20360326859188 0.0181622598253521 no 3296 0.0137761286106938 4678 91431 and experimental redox chemotherapeutic SGTC_3230 9131665 49.47 µM -2.2163017298303 0.0176639450962757 no 3297 0.0133354223227409 4752 15943720 SGTC_1997 st073024 93.8 µM -2.2224905432557 0.0174253422027489 no 3298 0.0131250862113913 4751 686268 SGTC_3021 9087658 49.47 µM -2.22649925832396 0.0172722637699344 no 3299 0.012990379303477 4746 25237042 SGTC_1606 st000094 49.2 µM -2.2284362951432 0.0171987078953592 no 3300 0.0129257175164265 4743 1242210 SGTC_1160 4092-0570 10.5 µM -2.26888207524095 0.015722881865026 no 3301 0.0116377490212394 4735 4994975 SGTC_477 mead ethanolamide 10 µM -2.28031193093387 0.0153260396277209 no 3302 0.0112945973449546 4767 16061185 SGTC_797 k781-0471 270 µM -2.28130597029142 0.0152919369521398 no 3303 0.0112651738440304 4719 23738129 SGTC_2828 7998861 71.43 µM -2.29071587990284 0.0149723254874261 no 3304 0.0109899257888968 4740 2988188 SGTC_2983 9022671 12.99 µM -2.29243538618145 0.0149145465302668 no 3305 0.0109402660247431 4725 6405161 SGTC_102 gallobenzophenone 83.616 µM -2.29405291360794 0.0148603693605357 no 3306 0.0108937297761796 4732 70837 SGTC_820 1582-0060 59.9 µM -2.30511820812553 0.0144942693954895 no 3307 0.0105799770007465 4746 3848840 SGTC_2524 avocatin b 10.57 µM -2.30580431734969 0.0144718270404815 no 3308 0.010560784443348 4750 6710748 SGTC_2669 eugenol 100 µM -2.34929119028514 0.0131091089054569 no 3309 0.00940459534802852 4776 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism. SGTC_1359 1582-0056 520 nM -2.40748604830811 0.0114599286089731 no 3310 0.00803138796703411 4768 3661189 SGTC_466 geldanamycin 89.2 µM -2.42217591287631 0.0110732897691953 no 3311 0.00771394009441609 4774 5288382 HSP90 inhibitor. SGTC_2999 9069765 71.4286 µM -2.42727279746345 0.0109418161117591 no 3312 0.00760640605794759 4713 2097066 SGTC_2196 6573537 42.6665 µM -2.45396879976193 0.0102751549656677 no 3313 0.00706446198573373 4764 2903087 SGTC_2523 spermine 47.74 µM -2.4622795854059 0.0100749770821545 no 3314 0.00690285002943499 4754 1103 A DNA binding polyamine. SGTC_1483 3453-0561 55.9 µM -2.46507766395422 0.0100083511546613 no 3315 0.00684917783002344 4775 4546991 SGTC_1923 st058458 19.1 µM -2.47848244294492 0.00969447276291456 no 3316 0.00659713022724552 4742 3534982 SGTC_784 4579-0127 173 µM -2.48698993914166 0.00949975813172114 no 3317 0.00644145211351889 4763 1948547 SGTC_1270 0831-1170 17.3 µM -2.49063190914313 0.00941745365392531 no 3318 0.00637580757195548 4773 6764716 SGTC_1333 1482-0047 286 µM -2.51322749010156 0.00892062179478221 no 3319 0.00598160817143714 4765 3811116 SGTC_1553 gossypol 38.6 µM -2.52873839599943 0.00859300353736267 no 3320 0.00572366576928003 4761 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_2740 felodipine 17.08 µM -2.55228637089242 0.00811580073285256 no 3321 0.00535092581799283 4787 3333 L-type calcium channel blocker SGTC_1313 1220-0047 237 µM -2.55266144056815 0.00810839219778929 no 3322 0.00534516769363094 4778 3528706 SGTC_1379 2144-0755 36.5 µM -2.55678486830913 0.008027335521412 no 3323 0.00528222653773076 4766 5392327 SGTC_3162 9099653 49.47 µM -2.55941602667357 0.00797598633824447 no 3324 0.00524240915427418 4767 25237511 SGTC_542 3381-0244 89.3 µM -2.61130837120073 0.00702063360428704 no 3325 0.00450982607326157 4765 1112843 SGTC_2391 6285546 200 µM -2.61351258401662 0.00698239025950999 no 3326 0.00448083916992992 4768 846083 SGTC_2615 purpurogallin-4-carboxylic acid 100 µM -2.61629359701671 0.00693440181689163 no 3327 0.00444450441241527 4728 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase. SGTC_2886 9058944 51.95 µM -2.67987418306609 0.0059138836348258 no 3328 0.00368249184331447 4790 4949929 SGTC_1994 st072947 40.9 µM -2.68040409751721 0.00590596992972684 no 3329 0.00367666657993361 4784 5286565 YDL195W SEC31 SGTC_2896 9052656 71.43 µM -2.69177268645078 0.00573843924800044 no 3330 0.00355366847039366 4476 6469436 SGTC_2752 diclazuril 33.15 µM -2.7230902729063 0.00529854469255599 no 3331 0.00323371915023986 4721 456389 An antifungal agent for coccidioides. YHR062C RPP1 SGTC_990 3985-0011 41.3 µM -2.72577273771432 0.00526229841923505 no 3332 0.00320755758824381 4771 5399565 YGL099W LSG1 SGTC_882 0843-0131 351 µM -2.81359464922928 0.00419106869148466 no 3333 0.00244954806925243 4787 5425421 SGTC_1332 1480-0653 17.5 µM -2.84135170556099 0.00389561787087698 no 3334 0.00224613696512846 4789 5749438 SGTC_968 1309-0633 340 µM -2.84137830999107 0.00389534387663303 no 3335 0.00224594957045639 4791 3761976 SGTC_2377 9073351 62.6 µM -2.84451276513392 0.00386318328620468 no 3336 0.00222397017726859 4778 7337946 YHR072W ERG7 SGTC_512 prima-1 270 µM -2.87371538767843 0.00357479916108793 no 3337 0.0020283717882136 4790 322968 A re-activator of the apoptotic function of mutant p53. SGTC_1256 0570-0116 285 µM -2.90865264057661 0.00325527111412822 no 3338 0.00181494963652947 4777 410638 SGTC_1140 3229-1848 2.98 µM -2.91682912242491 0.00318430413226023 no 3339 0.00176804719003397 4775 2849525 SGTC_1602 st001878 87.6 µM -2.97746380267747 0.00270001026082111 no 3340 0.00145321981186274 4787 595405 YLR310C CDC25 SGTC_2069 5228469 200 µM -3.03148785801471 0.00232565337324815 no 3341 0.0012167585380378 4782 2835210 SGTC_1750 st081859 2.357 µM -3.06300309249747 0.00212962535642031 no 3342 0.00109563897671829 4752 5291695 SGTC_2915 7971052 15.16 µM -3.08347453632576 0.00201044897315046 no 3343 0.00102299309337036 4792 5741558 SGTC_1738 st035555 74 µM -3.08436915482596 0.00200538170230092 no 3344 0.00101992157461938 4783 5331140 SGTC_1689 st020265 53.493 µM -3.14343502219935 0.00169539341223659 no 3345 0.000834887414286574 4799 5758320 YPR016C TIF6 SGTC_1682 st012968 530 nM -3.5291865406074 0.000531534907586792 yes 3346 0.000208419597087148 4790 24207270 SGTC_1119 parthenolide 318.541 nM -3.56040533838045 0.000481583191952566 yes 3347 0.000185141389577959 4795 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs. SGTC_959 1222-0044 107 µM -3.57296373595078 0.000462744314726195 yes 3348 0.000176481828427049 4799 6083612 SGTC_1004 4084-0029 199 µM -3.60008785797827 0.000424362263090414 yes 3349 0.000159054838192141 4806 716894 YLR208W SEC13 SGTC_2390 9097792 176.6 µM -3.70781312799181 0.000299253929852426 yes 3350 0.000104528416746227 4806 4497149 SGTC_2384 9036245 200 µM -3.75286844702099 0.000257916524806766 yes 3351 8.74113047521991e-05 4807 6462766 SGTC_1616 st002734 56.1 µM -3.78484159299681 0.000231880832137355 yes 3352 7.69032574753674e-05 4792 4026101 SGTC_3039 9090270 49.47 µM -4.09773506258065 7.8606701604557e-05 yes 3353 2.08606204279059e-05 4804 17173750 SGTC_1203 3992-3522 103 µM -4.11910954172852 7.28117413693788e-05 yes 3354 1.90169659351711e-05 4795 5322312 SGTC_2375 9072683 200 µM -4.31757542888042 3.51768654249184e-05 yes 3355 7.88762532031958e-06 4810 16798029 SGTC_1138 3761-0006 1.03 µM -4.34691229625877 3.15108508771227e-05 yes 3356 6.90336968858467e-06 4794 12061087