SGTCid condition conc unit EMP24|YGL200C.score EMP24|YGL200C.strain.pval EMP24|YGL200C.strain.significant EMP24|YGL200C.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene
SGTC_145 3737-0113 38.366 µM 7.55176237154148 1.58710970526941e-14 yes 1 2.14703718836853e-14 11 6849351
SGTC_2666 tannic acid 100 µM 7.53770790244441 1.77056439482848e-14 yes 2 2.39151859850918e-14 5 16134267 A thiamine antagonist.
SGTC_3040 9091894 49.47 µM 7.53052948363241 1.87215562512418e-14 yes 3 2.5267489172839e-14 3 25236966
SGTC_264 promethazine 12.5 mM 6.12579902519651 3.82893440908544e-10 yes 4 4.51148200528379e-10 18 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3
SGTC_17 0960-0276 49.807 µM 6.02643814472682 7.17151174030909e-10 yes 5 8.38062085826844e-10 4 6821114
SGTC_2643 anethole 100 µM 5.86909459480948 1.8987176783748e-09 yes 6 2.19090696988537e-09 3 637563 An anti-fungal, anti-helmenthic and channel blocker.
SGTC_1290 0986-0249 10.2 µM 5.28163807624824 5.79345486036577e-08 yes 7 6.40169674402196e-08 7 53329
SGTC_2448 5185112 27.17 µM 5.27034839696585 6.16613236401968e-08 yes 8 6.80825262108636e-08 5 5718189
SGTC_77 0828-0286 12.516 µM 5.20284963314052 8.92789712266196e-08 yes 9 9.81278299023509e-08 9 745345
SGTC_471 1-acyl-paf 4 µM 5.0236539032713 2.33343418402635e-07 yes 10 2.53487813618429e-07 13 16759367
SGTC_144 4161-2749 112.381 µM 5.02295315489977 2.34207180408637e-07 yes 11 2.54414793825813e-07 10 797501 YMR168C CEP3
SGTC_3094 9117742 49.47 µM 4.29255330778663 8.47596590415548e-06 yes 12 8.8315062740489e-06 14 17149698
SGTC_9 0092-0002 10.449 µM 4.28625665860313 8.72245661447676e-06 yes 13 9.0854520665423e-06 22 759368
SGTC_407 eburnamonine 100 µM 4.19911892701052 1.29181742020287e-05 yes 14 1.33977783621936e-05 9 3195
SGTC_470 aa-861 153 µM 4.15826666307998 1.54902348674971e-05 yes 15 1.60335779450716e-05 47 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor.
SGTC_867 0518-0118 155 µM 4.14003704703584 1.67887633011144e-05 yes 16 1.73624868452528e-05 17 6848158
SGTC_1415 3966-0071 78.1 µM 4.12742757471038 1.77467527418257e-05 yes 17 1.8342195754835e-05 9 2893185
SGTC_330 1488-0319 80.1 µM 4.12538964116996 1.79063736944561e-05 yes 18 1.85053811784545e-05 8 6846614
SGTC_1060 3448-7350 82 µM 4.09234140839606 2.06930543611039e-05 yes 19 2.13519647631994e-05 32 570178
SGTC_85 0868-0259 160.055 µM 3.77455940603296 7.87670918870532e-05 yes 20 8.01453543893078e-05 12 83173
SGTC_3129 9127257 49.47 µM 3.72855786853294 9.48113263493686e-05 yes 21 9.62893445465932e-05 30 837894
SGTC_2958 9077254 16.72 µM 3.7229799280337 9.69533465294345e-05 yes 22 9.84425898023362e-05 38 16457351
SGTC_2675 theaflavin digallate 100 µM 3.71108051515401 0.000101675824022641 yes 23 0.000103188221655781 36 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative.
SGTC_1914 st062367 72.6 µM 3.63128567508279 0.000139377214201469 yes 24 0.000141006402350148 28 978205
SGTC_1926 methyl fluorone black 53.6 µM 3.62467765531447 0.000143026139712182 yes 25 0.000144661041717654 75 72721 Reacts with homocysteine.
SGTC_512 prima-1 270 µM 3.60204978749394 0.000156210479306564 yes 26 0.000157858938517538 34 322968 A re-activator of the apoptotic function of mutant p53.
SGTC_511 blebbistatin 171 µM 3.59178007803172 0.000162562236913302 yes 27 0.00016421347790629 27 3476986 A myosin inhibitor.
SGTC_2645 abamectin 100 µM 3.55534232083387 0.000187102432925252 yes 28 0.000188743639983972 43 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels.
SGTC_2161 5662504 8.5105 µM 3.55088107893613 0.000190334335255313 yes 29 0.000191971928706372 34 2859334
SGTC_257 daunorubicin 18.5 µM 3.53612940369781 0.000201396391628367 yes 30 0.000203017874682097 32 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_143 4032-1194 15.74 µM 3.52494858108809 0.000210177758843309 yes 31 0.000211782499537341 86 1806963
SGTC_1396 3511-0007 98.6 µM 3.51197018702515 0.000220818938271214 yes 32 0.00022239894619061 23 X1396
SGTC_2015 5119600 184 µM 3.47303706660571 0.000255835003128727 yes 33 0.000257302139578507 42 2828786
SGTC_219 mitoxanthrone 164.414 µM 3.47206221853896 0.000256774822998495 yes 34 0.000258238310720228 64 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA. YMR168C CEP3
SGTC_1243 0416-0003 5.65 µM 3.45797006856305 0.000270725136296984 yes 35 0.000272130924010803 47 2141977
SGTC_3218 9131285 49.47 µM 3.4550973014887 0.000273654280310746 yes 36 0.000275047130590424 70 17156417
SGTC_750 4073-0104 132 µM 3.33759466645956 0.000422105936064 yes 37 0.000422534645046748 26 22330957
SGTC_701 4424-0219 185 µM 3.32601261570235 0.000440213239815792 yes 38 0.000440489705631717 32 2911779
SGTC_2445 5742597 35.57 µM 3.26831233091626 0.000541640215832625 yes 39 0.000540954505365401 65 1774255
SGTC_1834 st055981 52.8 µM 3.24939426703802 0.000579340766742249 yes 40 0.00057825531418428 63 471719 YDL150W RPC53
SGTC_370 0180-0345 38.7 µM 3.23386265709919 0.00061208999484259 yes 41 0.000610640855485401 30 3989527
SGTC_181 1447-1644 8.07 µM 3.22311129954603 0.000635752239938594 yes 42 0.000634031358266192 60 534600
SGTC_1299 1079-1439 3.74 µM 3.13817308601812 0.000854562867895149 yes 43 0.000850022278545372 42 323161
SGTC_2963 9082507 9 µM 3.12261355379144 0.000901472174633298 yes 44 0.000896264709400402 60 16459611
SGTC_2644 guaiazulene 100 µM 3.11148589530749 0.000936459157972504 yes 45 0.000930741831819998 16 3515 A coloring agent.
SGTC_3014 9081533 49.47 µM 3.10464933481758 0.000958568451115546 yes 46 0.000952523663509577 30 21367265
SGTC_2780 5215298 71.43 µM 3.09677644707756 0.00098462249009624 yes 47 0.000978186751702055 87 2834131
SGTC_3148 9097893 49.47 µM 3.05959310287914 0.00111668559562532 no 48 0.00110818943306435 73 17174100
SGTC_804 1595-0054 20.9 µM 3.05776393064845 0.00112358303894432 no 49 0.00111497585816206 82 761523 Stimulates phospholipase C.
SGTC_2489 cantharidin 73.42 µM 3.04934913117739 0.00115581921151983 no 50 0.00114668894909193 94 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_393 acivicin 6.25 µM 2.99211666339641 0.001398524911106 no 51 0.00138525183144243 47 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1
SGTC_2982 9019404 25.97 µM 2.962936559807 0.00153942165591055 no 52 0.00152359682370681 60 22333232
SGTC_1943 st076331 65.2 µM 2.94889887109377 0.00161171258704519 no 53 0.00159454156393618 54 24208415
SGTC_2499 avocadenofuran 51.48 µM 2.94834007503979 0.00161465326218591 no 54 0.00159742697604234 95 6857792 A insecticide and lysyl oxidase inhibitor.
SGTC_1947 st076332 61.6 µM 2.93626127288285 0.00167942514878048 no 55 0.00166097200001327 50 24208416
SGTC_757 1066-0008 322 µM 2.92521308387885 0.0017407330348725 no 56 0.00172110216703004 65 6842497
SGTC_2921 7974240 10.71 µM 2.92294658520451 0.00175355918381953 no 57 0.00173367996418434 105 2979074 YDR527W RBA50
SGTC_785 1270-0111 65.3 µM 2.90385898462027 0.00186503587438381 no 58 0.00184297068108614 82 6741994
SGTC_630 4356-0227 183 µM 2.90222075571929 0.00187489754341129 no 59 0.00185263666638325 42 779312
SGTC_849 0386-0493 241 µM 2.89699181706023 0.00190669215420941 no 60 0.0018837979121886 63 726119
SGTC_773 4358-1457 44.6 µM 2.89117576739939 0.00194263163134325 no 61 0.00191901699010219 100 1186886
SGTC_2597 laccaic acid a 100 µM 2.88009468119348 0.00201281352139432 no 62 0.00198777880791869 85 5491415 A textile dye.
SGTC_789 1309-1135 70.6 µM 2.86232891307601 0.00213014764513602 no 63 0.00210270118057953 89 3092424
SGTC_15 0266-0086 27.098 µM 2.85860652799444 0.00215550466280256 no 64 0.0021275310593237 143 1712902 YIL048W NEO1
SGTC_68 0986-0284 82.829 µM 2.82863629868102 0.00236984809274748 no 65 0.00233733953315938 151 423278 YIL048W NEO1
SGTC_2781 5567276 71.43 µM 2.82112901825106 0.0024264767113522 no 66 0.00239274761104723 126 2853274
SGTC_1992 st073643 23.3 µM 2.77244417224673 0.00282439603975543 no 67 0.00278185309969659 56 3161292
SGTC_2787 5284540 71.43 µM 2.77131293271139 0.00283430445488311 no 68 0.00279153710622049 91 736958
SGTC_378 3970-0959 8.33 µM 2.75940999402943 0.00294047775140942 no 69 0.00289529178887205 77 6615653
SGTC_255 tunicamycin 200.472 nM 2.75494390512679 0.00298123089815564 no 70 0.00293510994238473 165 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_50 0929-0078 56.389 µM 2.73498917840719 0.003169604903454 no 71 0.00311911634401217 122 1377751
SGTC_769 0302-0231 76 µM 2.70939167400934 0.00342690414151022 no 72 0.00337033564024087 150 571869 YER009W NTF2
SGTC_2108 5365811 200 µM 2.69803437669199 0.00354695934512891 no 73 0.0034875118736376 86 780283
SGTC_58 0957-0393 9 µM 2.68390956375151 0.00370153052429153 no 74 0.00363833934200435 544 6997992
SGTC_3098 9119039 49.47 µM 2.67129932639776 0.00384460364782377 no 75 0.00377791179090863 106 17161528
SGTC_2018 5133068 143 µM 2.66248513883115 0.00394753013967116 no 76 0.00387829973167925 101 785362
SGTC_1044 1222-0021 1.78 µM 2.65088928277862 0.00408669619799363 no 77 0.00401400766340231 113 4306703
SGTC_3087 9117406 49.47 µM 2.6441612981447 0.00416943923588299 no 78 0.00409468104176172 82 42546093
SGTC_784 4579-0127 173 µM 2.64376605366962 0.00417434637095704 no 79 0.00409946512321995 97 1948547
SGTC_3093 9117344 49.47 µM 2.63405092426837 0.00429659955868328 no 80 0.00421864162412894 96 24824913
SGTC_1024 4507-0395 26 µM 2.58419421111611 0.00497574797623027 no 81 0.00488034074195194 118 4201836
SGTC_3283 9109332 35.8195 µM 2.56138887740948 0.00531711389445419 no 82 0.00521272934894296 79 17027281
SGTC_775 4577-0580 57.3 µM 2.55280083286898 0.00545096797341659 no 83 0.00534302912742105 71 2006902
SGTC_125 0133-0007 11.75 µM 2.54439772577889 0.00558482984839367 no 84 0.00547331815866691 90 26541
SGTC_658 3253-0951 102 µM 2.54375060849917 0.00559525852973116 no 85 0.00548346773966194 174 1184878
SGTC_1303 1160-0052 261 µM 2.54248899834729 0.00561563987024412 no 86 0.00550330330874791 88 3562476
SGTC_2880 9042983 58.44 µM 2.53386819777747 0.00575668222624899 no 87 0.00564055772470904 121 6464714
SGTC_815 1582-0027 36.9 µM 2.52551521376772 0.00589633271678189 no 88 0.00577643895817444 117 3128206
SGTC_2832 7992762 51.95 µM 2.51186843929912 0.00613095933505695 no 89 0.00600469252455662 122 2985177
SGTC_779 1360-0071 233 µM 2.5111251716567 0.00614397250087357 no 90 0.00601735078099904 137 7566
SGTC_2648 atorvastatin 78.68 µM 2.50251420815008 0.00629652710542185 no 91 0.00616573378710159 91 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11
SGTC_2102 5377816 72.7585 µM 2.49143640596328 0.00649771185488959 no 92 0.00636138703981724 112 1379702
SGTC_809 3998-0021 90 µM 2.49063243944573 0.00651253165700728 no 93 0.00637579805680858 75 715485
SGTC_1014 4130-3005 69.3 µM 2.47641324890343 0.00677962467377529 no 94 0.0066354935906908 137 743608
SGTC_762 1165-0429 115 µM 2.4715128265727 0.00687389142440955 no 95 0.00672713623426718 114 5967793
SGTC_468 gf-109203x 121 µM 2.46405011727859 0.00701967151804237 no 96 0.00686884505367889 46 2396 A protein kinase C inhibitor.
SGTC_2606 farnesol 9.78 µM 2.46179953165085 0.00706416782817675 no 97 0.00691209555959544 123 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_3012 9080433 71.4286 µM 2.43667671788455 0.00757802312627132 no 98 0.00741146233596421 112 17688859
SGTC_438 sphingosine 6.67 µM 2.43267895292584 0.00766275891836565 no 99 0.00749379166328341 111 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes.
SGTC_1048 3161-0300 24.5 µM 2.43212609207056 0.0076745426532142 no 100 0.00750524037105902 124 2165101
SGTC_2270 7924575 90.91 µM 2.43088080509817 0.00770114327912224 no 101 0.00753108437339807 124 1262135
SGTC_1137 ixabepilone 100 µM 2.4180554805379 0.00797986273632323 no 102 0.00780184875111185 175 154225 A novel microtubule stabilizer.
SGTC_2822 7994718 71.43 µM 2.41417088722766 0.00806601454021076 no 103 0.00788553181592602 96 1018011
SGTC_1955 wogonin 32.4 µM 2.40292087473602 0.00832014424320619 no 104 0.00813235313552526 106 5281703 A flavanone.
SGTC_2582 agaric acid 100 µM 2.39633440490691 0.0084721684082014 no 105 0.00827998716839555 554 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase.
SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM 2.39044993584505 0.00861004585724556 no 106 0.00841387160907398 181 368090
SGTC_990 3985-0011 41.3 µM 2.38778822221743 0.00867305560156436 no 107 0.00847505301293827 113 5399565 YGL099W LSG1
SGTC_925 2064-1272 59.6 µM 2.3759194565364 0.00895896776867736 no 108 0.00875264171676799 139 6815817
SGTC_1463 k081-0032 34.1 µM 2.37023253992137 0.00909886485746544 no 109 0.00888845029021661 75 977755
SGTC_2105 5350118 200 µM 2.37014185379555 0.00910111112725347 no 110 0.0088906308293865 128 2133313
SGTC_433 pimozide 108 µM 2.36994637940405 0.0091059546242464 no 111 0.00889533258652396 95 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic
SGTC_2365 9042475 200 µM 2.36881554204902 0.00913401901996141 no 112 0.00892257546927532 150 6464479
SGTC_2399 5884133 200 µM 2.36380418944243 0.00925930087068226 no 113 0.00904418510751885 213 722445
SGTC_1468 k284-1086 134 µM 2.35899131874507 0.00938103374748493 no 114 0.00916234222119345 202 15996457
SGTC_992 3909-8734 162 µM 2.3525064447882 0.00954726964097922 no 115 0.0093236833122778 136 4288319
SGTC_105 0111-0055 734.78 µM 2.35217950891379 0.00955571821512475 no 116 0.00933188275995494 85 5179370
SGTC_2328 6201408 200 µM 2.35214307869743 0.00955666003792248 no 117 0.00933279680871697 132 2890418
SGTC_1461 k072-0203 53.8 µM 2.35152154666639 0.00957274088306564 no 118 0.00934840336927029 130 5418714
SGTC_2797 7859098 81.82 µM 2.34981360227095 0.0096170522483339 no 119 0.00939140718340146 148 972681
SGTC_92 0063-0024 660.874 µM 2.34813984871226 0.00966065037598147 no 120 0.00943371789100544 122 3594437
SGTC_469 w7 172 µM 2.34067956498475 0.00985708397487659 no 121 0.00962433984770895 72 45115570 A P450 inhibitor.
SGTC_569 4130-2812 160 µM 2.32724876828331 0.0102195280522614 no 122 0.009976014385012 94 743552
SGTC_2849 9019321 12.99 µM 2.32214669885464 0.0103602290140479 no 123 0.010112518938675 166 16489627
SGTC_2600 tangeritin 87.95 µM 2.29909799140134 0.011017098894417 no 124 0.0107496877727069 146 68077 A bioactive flavone.
SGTC_1612 st002233 45.4 µM 2.29061496319496 0.0112678228061386 no 125 0.0109928463709626 134 1035021
SGTC_1389 3405-0187 19 µM 2.28672382162403 0.0113844787655883 no 126 0.0111059741766184 141 799890
SGTC_913 3487-1245 167 µM 2.28583340784459 0.0114113203303463 no 127 0.0111320032190113 181 4016153
SGTC_148 3253-0744 288.01 µM 2.28415062587027 0.0114621980426779 no 128 0.0111813400729536 153 6893655
SGTC_2937 9044753 11.33 µM 2.28276578173955 0.0115042155071906 no 129 0.0112220842930123 195 6465530 YGL099W LSG1
SGTC_911 3456-4043 236 µM 2.27736587998765 0.0116693339455073 no 130 0.0113821929209972 176 914281
SGTC_3137 9097352 49.47 µM 2.26674150080253 0.0120002205648132 no 131 0.0117030108038288 211 44120435
SGTC_1584 6-fluoro-dl-tryptophan 90 µM 2.25529193988422 0.0123658859222302 no 132 0.0120575051098251 165 94937 An inhibitor of serotonin biosynthesis.
SGTC_660 4031-1742 102 µM 2.24344414205021 0.0127543921031837 no 133 0.0124340940360201 206 6738706
SGTC_2278 7948257 134.34 µM 2.23374589933945 0.0130802282998263 no 134 0.0127498985317941 146 1247028
SGTC_790 1575-0012 79.1 µM 2.21284611695785 0.0138069462795562 no 135 0.0134541283035053 180 378741 YLR208W SEC13
SGTC_2037 5169046 200 µM 2.21020645038826 0.0139011633291331 no 136 0.013545418758214 133 5718022
SGTC_2607 solasodine 47.35 µM 2.204058843266 0.0141227398963888 no 137 0.0137601030421508 214 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity.
SGTC_2934 9036370 36.88 µM 2.20355315629764 0.0141411009580201 no 138 0.0137778923732971 200 6462800
SGTC_2128 5255449 168.493 µM 2.20031095543149 0.0142593118907479 no 139 0.0138924202686609 201 736008
SGTC_2813 7971799 71.43 µM 2.19660474581533 0.0143954823033368 no 140 0.0140243434992201 162 2234054
SGTC_2316 5844804 197.44 µM 2.19637704228431 0.0144038847789957 no 141 0.0140324837405866 235 776813
SGTC_633 0437-0093 97.7 µM 2.19143361187039 0.0145873457720008 no 142 0.0142102145044042 141 2831118
SGTC_3020 9089140 49.47 µM 2.18735230362122 0.0147403235849007 no 143 0.0143584076118332 160 17217859
SGTC_1756 st041558 35.5 µM 2.18415011179969 0.0148613140826196 no 144 0.0144756097016616 159 3955792
SGTC_230 MPP+ 141.667 µM 2.16598535123796 0.0155639278780461 no 145 0.015156153174642 169 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death.
SGTC_126 0417-1624 672.48 µM 2.14740703333196 0.016311838249072 no 146 0.015880445604493 234 41912 YDL195W SEC31
SGTC_2915 7971052 15.16 µM 2.14512876943701 0.0164056397537853 no 147 0.0159712763901135 100 5741558
SGTC_2702 st077768 96.8 µM 2.13969821333351 0.0166310928538751 no 148 0.0161895817715627 170 6484119
SGTC_423 5-fluorouracil 457 µM 2.12648484996302 0.017190753951137 no 149 0.0167314546996983 195 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_2191 5911152 200 µM 2.1239048788998 0.0173018880661263 no 150 0.0168390491746317 174 2875902
SGTC_2097 5376186 200 µM 2.12137887968264 0.0174112913036822 no 151 0.0169449655761401 200 742755
SGTC_613 3914-0030 117 µM 2.10419890600357 0.0181711552637921 no 152 0.0176805499685484 39 1145395
SGTC_1075 aripiprazole 15.2 µM 2.10292674601274 0.0182285295075181 no 153 0.0177360867167397 233 60795 An atypical antipschotic. YIL048W NEO1
SGTC_2319 6033012 152.6 µM 2.09437149126108 0.018618394113857 no 154 0.0181134501553659 153 847246
SGTC_3034 9090421 49.47 µM 2.09109724448423 0.0187694690548354 no 155 0.0182596738404676 146 17173761
SGTC_1194 1488-0194 225 µM 2.07910129687007 0.0193319096137508 no 156 0.0188040204682949 218 1391452
SGTC_3006 9075424 71.4286 µM 2.07660530088388 0.019450719427568 no 157 0.0189190016276816 187 7465181
SGTC_2614 arthonioic acid 13.39 µM 2.07279379103078 0.0196333444686932 no 158 0.0190957372648066 185 6710684
SGTC_2077 5212015 200 µM 2.06707607983791 0.0199100325869818 no 159 0.0193634928277517 236 780900
SGTC_747 3448-8087 38.7 µM 2.06682586335897 0.0199222161018194 no 160 0.019375282745932 229 5168703
SGTC_2346 9031566 143.75 µM 2.05627388213394 0.0204418014286007 no 161 0.0198780621536572 184 4771086
SGTC_106 0092-0003 11.579 µM 2.04843558584041 0.0208351568578455 no 162 0.0202586688286942 141 1072148
SGTC_2051 5263410 176 µM 2.04703704066728 0.020906010614384 no 163 0.020327223910492 195 227584
SGTC_1429 4049-0205 9.46 µM 2.03101683540317 0.0217322861050911 no 164 0.0211266434103499 210 22774478
SGTC_347 4534-1311 26.2 µM 2.03060645434366 0.0217538096834529 no 165 0.0211474662337029 192 2862016
SGTC_1590 st077108 57.8 µM 2.02653212534175 0.0219684777565481 no 166 0.0213551420502527 154 5489485
SGTC_1062 mesoridazine 14.2 µM 2.0252873976235 0.0220344155222203 no 167 0.0214189309105199 229 4078 A neuroleptic.
SGTC_2924 9010168 62.78 µM 2.01775117440481 0.0224372144380705 no 168 0.0218085911174825 232 2993929
SGTC_2148 5546263 113.568 µM 2.0168420602889 0.0224862222560821 no 169 0.0218559990410062 207 792097
SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM 2.01671031679501 0.0224933316647775 no 170 0.0218628763344215 195 7104
SGTC_1708 st033234 31.827 µM 2.00527126889382 0.0231178970149044 no 171 0.0224670273032179 215 674664
SGTC_2526 patulin 37.61 µM 2.00429968279468 0.0231716114007057 no 172 0.0225189839197713 331 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.
SGTC_91 0417-1751 58.384 µM 2.00416826795901 0.0231788847643654 no 173 0.0225260192424647 292 6795624
SGTC_1356 1502-0781 85.8 µM 2.00330968423754 0.0232264517655523 no 174 0.022572029336753 206 567702
SGTC_1815 st051655 58.2 µM 1.99245721660789 0.0238348138307718 no 175 0.0231604574524024 161 5984156
SGTC_1915 st067105 30.6 µM 1.98911740054116 0.0240247097513862 no 176 0.0233441230692592 255 69751 YOR207C | YOR116C RET1 | RPO31
SGTC_2029 5175081 200 µM 1.96784516309202 0.0252642722737493 no 177 0.0245429279636901 253 1380876
SGTC_976 1348-1067 47.6 µM 1.96748625502911 0.0252856376041328 no 178 0.0245635894948746 251 5310671 YGL099W LSG1
SGTC_2573 2',4'-dihydroxychalcone 15.04 µM 1.96290223737067 0.0255598521595206 no 179 0.0248287673813585 307 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_465 cgp-37157 41 µM 1.95827332585795 0.0258392745570476 no 180 0.0250989745094764 140 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange.
SGTC_1732 st034308 51.822 µM 1.95648946712341 0.0259476366726843 no 181 0.0252037610152468 242 830119
SGTC_1487 3970-0795 2.82 µM 1.95594022066135 0.0259810775980648 no 182 0.0252360982878158 222 3765103
SGTC_2356 9061756 188.97 µM 1.95391816876335 0.0261045012687804 no 183 0.0253554477605859 167 20104043
SGTC_2141 5621638 7.665 µM 1.94483841970856 0.0266647786854921 no 184 0.0258972142364536 207 2856238
SGTC_204 PMA1.184 62.41 µM 1.93855344750463 0.0270584548894562 no 185 0.0262778683693861 257 2252213 YGL008C PMA1
SGTC_1416 3966-0321 25.3 µM 1.93138545028708 0.0275133503975686 no 186 0.0267177015516758 255 582530 YLR208W SEC13
SGTC_579 4491-1009 110 µM 1.91995537217631 0.0282519051578225 no 187 0.0274317683644817 325 1271041
SGTC_1950 st077106 7.18 µM 1.91825088327623 0.0283634419543909 no 188 0.0275396035459119 262 13831864
SGTC_858 0438-0351 2.77 µM 1.91548707025285 0.0285450765156653 no 189 0.0277152082582428 252 2799119
SGTC_1277 0873-0036 22 µM 1.91284637379519 0.0287195228419899 no 190 0.0278838612147957 287 5965735
SGTC_601 0986-0029 62.9 µM 1.91144052217679 0.0288127554399594 no 191 0.0279739967004881 294 24747981
SGTC_383 2324-0395 7.37 µM 1.90891927213779 0.0289805887462642 no 192 0.0281362532389316 267 3146421
SGTC_3125 9127534 49.47 µM 1.90759623549808 0.0290689845197889 no 193 0.0282217110392083 162 1639235
SGTC_1807 st050092 58.9 µM 1.90375303870879 0.0293270306155926 no 194 0.0284711776225078 245 5008496
SGTC_2931 9014674 55.67 µM 1.90367115034843 0.0293325495268359 no 195 0.0284765129936977 256 2996810
SGTC_1716 st033144 30.6155 µM 1.90082211950163 0.0295250991900084 no 196 0.0286626578902272 263 674617
SGTC_2686 alizarin 95.37 µM 1.89750607383942 0.0297505317983163 no 197 0.0288805889590136 245 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1
SGTC_854 0422-0053 192 µM 1.89314546953984 0.0300491479089391 no 198 0.0291692634018455 227 3596728
SGTC_112 phenothiazine 287.218 µM 1.89110279811385 0.0301898833626945 no 199 0.0293053115425896 221 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.
SGTC_285 1486-1325 46 µM 1.88556785383157 0.0305739767061221 no 200 0.0296766063473291 265 22310230
SGTC_2289 7946404 165.07 µM 1.88197211559652 0.0308256624029411 no 201 0.0299199008760369 353 1246120 YPR165W RHO1
SGTC_844 0330-0132 15.3 µM 1.87692924087706 0.0311815284203713 no 202 0.030263896282306 247 2828079
SGTC_2740 felodipine 17.08 µM 1.87687736203997 0.0311852069962384 no 203 0.030267452115504 186 3333 L-type calcium channel blocker
SGTC_166 k072-0058 166.424 µM 1.87478485185584 0.0313338802523966 no 204 0.0304111639901637 274 5846229
SGTC_2889 9059656 51.95 µM 1.87421822970308 0.0313742395592011 no 205 0.030450176258585 248 3949838
SGTC_869 0564-0080 44.1 µM 1.87104178084052 0.0316012879855372 no 206 0.030669645061449 294 6843321
SGTC_1794 st048918 76.9 µM 1.86961942948688 0.0317033950866735 no 207 0.0307683426046997 175 672303
SGTC_761 k216-0224 480 µM 1.8659383490361 0.0319689170451304 no 208 0.0310249957312509 258 1340404
SGTC_1726 st035556 14.5795 µM 1.86558828060613 0.0319942633645672 no 209 0.0310494952568871 307 5919439
SGTC_3044 9093193 49.47 µM 1.86082699641498 0.0323406496457802 no 210 0.0313843059068867 298 25236277
SGTC_2110 5483698 200 µM 1.85895199492635 0.0324779037347556 no 211 0.0315169715619342 248 2848765 YHR062C RPP1
SGTC_2853 9015042 58.44 µM 1.85863399302458 0.0325012297427697 no 212 0.0315395176854069 229 6457456
SGTC_679 0422-0091 41.4 µM 1.85333531889213 0.0328919347276033 no 213 0.0319171559289183 318 627384 YHR062C RPP1
SGTC_289 k017-0060 526 µM 1.84995135993033 0.0331434752964529 no 214 0.0321602801938336 220 5512909
SGTC_2647 atorvastatin 60.16 µM 1.83988154293372 0.0339013863497904 no 215 0.0328928151625215 251 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7
SGTC_1795 st049545 62.3 µM 1.83790646714326 0.0340517014153799 no 216 0.0330380944956394 234 5291882
SGTC_2031 5180455 200 µM 1.83741713249278 0.0340890272952816 no 217 0.0330741697681085 213 29949
SGTC_86 0417-1630 471.922 µM 1.83573122604394 0.0342178839849941 no 218 0.0331987086585091 444 3634867
SGTC_1213 1315-0166 115 µM 1.83203073757049 0.0345021227816956 no 219 0.0334734206368064 236 768401
SGTC_226 1,3-diallylurea 8.28947 mM 1.83137452090904 0.034552729469122 no 220 0.0335223308023444 238 74537 YKL182W FAS1
SGTC_1374 2889-5571 141 µM 1.83002977489862 0.0346566252752232 no 221 0.0336227433223941 313 2853281
SGTC_3294 9122953 26.2835 µM 1.82932858445609 0.0347109013181766 no 222 0.03367519949888 282 16459826
SGTC_744 1594-0068 283 µM 1.82590371088456 0.0349770096041208 no 223 0.033932383569216 323 668392
SGTC_874 0599-0792 117 µM 1.81871249029967 0.035541208397408 no 224 0.0344776525733864 329 765305
SGTC_1403 3909-7815 62.9 µM 1.81766077883508 0.0356243440743815 no 225 0.0345579979328496 221 6615483
SGTC_2674 ligustilide 100 µM 1.81110714766552 0.036145993665805 no 226 0.0350621336629125 219 5319022 A signalling regulator.
SGTC_163 TUB2.036 7.546 µM 1.80882123404122 0.0363294103986896 no 227 0.0352393901627588 478 15992207 YJR013W GPI14
SGTC_783 0848-0141 92.7 µM 1.80218600343717 0.0368661256768252 no 228 0.0357580730325402 264 6755076 YHR007C | YLR033W ERG11 | RSC58
SGTC_2251 lansoprazole 556 µM 1.80145109952367 0.0369259678766233 no 229 0.0358159041058569 222 3883 Gastric proton pump inhibitor. YBR192W RIM2
SGTC_2282 7944268 200 µM 1.79543331323322 0.0374189810843729 no 230 0.0362923443923208 325 2970414
SGTC_1746 st038117 42 µM 1.79373646300824 0.0375589648637956 no 231 0.0364276212228695 305 2898218
SGTC_1190 1486-1332 13 µM 1.78687450183515 0.0381294181005365 no 232 0.0369788872487282 274 4150046
SGTC_3197 9113331 49.47 µM 1.78248292331077 0.0384981961976076 no 233 0.0373352567734545 313 16610459 YLR208W | YDL195W SEC13 | SEC31
SGTC_622 1348-1566 26.3 µM 1.78078969584648 0.0386411574034266 no 234 0.0374734066952912 330 7340407
SGTC_1967 st070177 51.4 µM 1.7798938524136 0.0387169693194263 no 235 0.0375466669900351 257 5729214
SGTC_3065 9113888 49.47 µM 1.7762292640349 0.0390283524915052 no 236 0.0378475683551671 266 16648368
SGTC_2007 4011539 71.82 µM 1.77568861514427 0.0390744640069934 no 237 0.0378921274589552 318 45595301
SGTC_337 1315-0038 354 µM 1.7751697672343 0.0391187578302371 no 238 0.0379349300175192 278 1626437
SGTC_1362 1611-0397 101 µM 1.77299295050402 0.0393050374038868 no 239 0.0381149375019114 284 27816
SGTC_97 0535-0701 19.132 µM 1.76726579311415 0.0397985845123338 no 240 0.038591862852075 259 2832013 YGL099W LSG1
SGTC_1072 oxiconazole 14.9 nM 1.76330868470463 0.040142528938682 no 241 0.0389242206746947 340 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_329 k048-0121 21.3 µM 1.7615059998293 0.0403000135563479 no 242 0.0390763992032947 286 6832902
SGTC_1932 st074806 40.9 µM 1.75638956169202 0.0407497261570258 no 243 0.039510956977344 331 17251235
SGTC_277 nystatin 15.5 µM 1.75414762915869 0.0409480612269895 no 244 0.0397026071116407 313 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_467 ro 31-8220 72.8 µM 1.74955183689084 0.0413570808875183 no 245 0.0400978383406546 370 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7
SGTC_1663 st014140 55.4 µM 1.74860628528133 0.0414416431487602 no 246 0.0401795495532491 327 4207120
SGTC_2723 salbutamol 83.58 µM 1.74858798083159 0.04144328152773 no 247 0.0401811326924081 179 9884233 β2-adrenoceptor agonist
SGTC_3228 9131799 49.47 µM 1.74747830941441 0.0415427031294407 no 248 0.0402772020940418 272 17015818
SGTC_1776 st049249 45.9 µM 1.74136311463617 0.0420940692073185 no 249 0.0408099747198766 341 1822314
SGTC_1902 st060212 70.5 µM 1.74132988138213 0.0420970817292575 no 250 0.0408128856383451 307 688944
SGTC_1762 st045503 25.4615 µM 1.73705490116642 0.0424860566055506 no 251 0.0411887403543613 320 4645554
SGTC_1260 0700-1617 7.75 µM 1.7367035933254 0.0425181504738013 no 252 0.0412197515905484 342 2853078
SGTC_1089 terbinafine 2.25 µM 1.73398890752881 0.0427668132840097 no 253 0.0414600256718012 288 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_49 0717-0965 32.132 µM 1.72710234742205 0.0434028919280651 no 254 0.0420746420541691 322 5889349 YGL099W LSG1
SGTC_228 caffeine 993.056 µM 1.7224831648146 0.0438338075377242 no 255 0.0424910149489375 250 2519 Caffeine is a phosphodiesterase inhibitor.
SGTC_1094 duloxetine 25.4 µM 1.72022672269344 0.0440455583193858 no 256 0.0426956186681181 318 60834 A selective serotonin reuptake inhibitor.
SGTC_11 0438-0307 1.3 µM 1.71936025611426 0.0441270888014723 no 257 0.0427743971780804 284 4011476
SGTC_1036 k216-0215 33.5 µM 1.71900038157088 0.0441609870673212 no 258 0.0428071512233156 392 622330
SGTC_1179 1021-1431 9.29 µM 1.71846906964628 0.0442110721945441 no 259 0.0428555457265956 398 2840958
SGTC_3099 9120367 49.47 µM 1.71729813273986 0.0443216144437137 no 260 0.04296235652464 290 24824940
SGTC_66 0109-0187 42.4 µM 1.71107690268481 0.0449126703480009 no 261 0.043533458676797 329 759417
SGTC_1897 st060201 15 µM 1.7069495576865 0.0453082834489092 no 262 0.0439157142181263 280 611878
SGTC_828 2074-0507 139 µM 1.70605343220829 0.0453945479232356 no 263 0.0439990658594087 355 X828
SGTC_2200 6600604 21.907 µM 1.70526273457102 0.0454707731656004 no 264 0.0440727172046994 360 2904777
SGTC_2809 7964133 12.99 µM 1.70228912528454 0.0457583584569204 no 265 0.0443505911842981 370 1253665
SGTC_1154 4088-0362 150 µM 1.70213597063572 0.0457732099273572 no 266 0.0443649411259622 386 6618304
SGTC_1440 4100-1550 40 µM 1.70140051511843 0.0458445813346726 no 267 0.0444339023235038 253 742806
SGTC_2400 5203494 178.7 µM 1.69985498569288 0.0459948568337403 no 268 0.0445791029015305 297 6777674
SGTC_878 0828-0289 13.7 µM 1.69816420383938 0.0461597085820349 no 269 0.0447383872923599 400 745350 YLR208W SEC13
SGTC_1244 0416-0015 52.5 µM 1.69558756743644 0.0464118436714748 no 270 0.0449820069450373 335 96201
SGTC_229 benomyl 22.8748 µM 1.69340115071428 0.0466266601100696 no 271 0.0451895680038881 353 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C
SGTC_1650 st011916 45.8 µM 1.68906680908511 0.0470548693628775 no 272 0.0456033137891425 277 242528
SGTC_2661 dactinomycin 12.96 µM 1.6791601897761 0.0480454308704012 no 273 0.0465604141591496 361 45006140 An Actinomycin D Classic transcription inhibitor.
SGTC_1648 st011736 69.8 µM 1.67363863719128 0.0486047314936364 no 274 0.0471008201190904 314 2855514
SGTC_1442 4112-3290 3 µM 1.66414161903133 0.0495788882535122 no 275 0.0480420658054073 357 704353
SGTC_3191 9110352 49.47 µM 1.66018372363056 0.0499894418911057 no 276 0.0484387489917882 287 17122424
SGTC_2340 7987427 183.45 µM 1.65943158507006 0.0500677671382508 no 277 0.0485144280398654 331 2239331
SGTC_348 k064-0012 10.7 µM 1.65495502819282 0.0505359673814937 no 278 0.0489668103190857 302 5066323
SGTC_1519 esterone 74 µM 1.65486401358409 0.0505455225960885 no 279 0.0489760427163066 361 698 A steroid.
SGTC_642 0335-0876 158 µM 1.65459945887926 0.0505733051772081 no 280 0.0490028866796263 378 6812350
SGTC_825 1988-2224 89.6 µM 1.64991480420974 0.0510672884357194 no 281 0.0494801811871046 380 1180859
SGTC_1711 st032263 62.8 µM 1.64941085767629 0.0511206561185141 no 282 0.049531745918316 326 3958979
SGTC_2707 st078556 66.6 µM 1.64614321700662 0.0514677752834215 no 283 0.0498671383027468 314 17250899
SGTC_439 amiodarone 34.4 µM 1.64411514419348 0.0516841570513006 no 284 0.0500762101619475 418 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1
SGTC_1529 apigenin 74 µM 1.63977730878644 0.0521494024756311 no 285 0.0505257389244796 385 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_3096 9117468 49.47 µM 1.63885116644777 0.0522491635539815 no 286 0.0506221300249491 248 41316311
SGTC_1099 5-nonyloxytryptamine 2.85 µM 1.63171302453781 0.0530231554808245 no 287 0.051369977494836 357 23581825 A 5-HT1D beta serotonin receptor agonist.
SGTC_3170 9103054 49.47 µM 1.62912590601752 0.0533059125146915 no 288 0.0516431840462816 312 16432970
SGTC_2379 9035213 200 µM 1.62841140916895 0.0533842131204665 no 289 0.051718840021235 381 646551
SGTC_993 3909-8757 62.7 µM 1.62784325093842 0.0534465417381857 no 290 0.05177906349117 302 4288324 YLR208W SEC13
SGTC_1907 st060210 83.7 µM 1.62582272939724 0.0536686661463771 no 291 0.0519936858265084 393 688793
SGTC_3076 9116187 49.47 µM 1.62499639346066 0.0537597191305764 no 292 0.0520816636508003 320 27241210
SGTC_3123 9126162 49.47 µM 1.61599370115683 0.0547596609051612 no 293 0.0530478375279703 347 25239884
SGTC_1674 st016616 23.6 µM 1.61321080882849 0.0550717180611795 no 294 0.0533493579763851 379 625830
SGTC_1532 4',5'-dihydroxyflavone 78.7 µM 1.60519800801689 0.0559780770710851 no 295 0.054225117860428 373 165521
SGTC_2578 7,8-dihydroxyflavone 64.44 µM 1.60412281364907 0.056100586717629 no 296 0.0543434920561434 367 1880 Intensifies effect of antibiotics on Staphylococcus aureus.
SGTC_2521 angolensin 13.4 µM 1.59896735382346 0.0566909494204455 no 297 0.054913928332208 325 821428 A flavenoid.
SGTC_2144 5628481 200 µM 1.59820202579448 0.0567790044394959 no 298 0.0549990115267797 335 2818399
SGTC_2376 9072922 81.32 µM 1.5941240229507 0.057250017772395 no 299 0.055454129645821 405 17087968
SGTC_1723 st034307 2.5525 µM 1.59367876973168 0.0573016306109948 no 300 0.0555040008517498 369 867466
SGTC_967 1306-0166 352 µM 1.59188560238502 0.0575098616374125 no 301 0.0557052055781851 398 4437607
SGTC_2950 9072895 21.46 µM 1.59057079519849 0.0576629211072559 no 302 0.0558531006864386 430 17332245
SGTC_362 0310-0100 9.03 µM 1.5900001010573 0.0577294564321019 no 303 0.0559173911298871 403 790235
SGTC_2456 5770359 74.46 µM 1.58793832108969 0.0579703355854773 no 304 0.0561501435026679 354 3118787
SGTC_2219 9098279 200 µM 1.58557001351978 0.0582480006386977 no 305 0.0564184415021922 343 902349
SGTC_128 0906-2981 13.371 µM 1.58410307111916 0.0584205111627292 no 306 0.0565851328162876 330 6740226
SGTC_2009 4012297 12.05 µM 1.58218734597132 0.0586464017946879 no 307 0.0568034041237589 389 45595307
SGTC_1799 st045822 46.1415 µM 1.57996302606757 0.0589095396300617 no 308 0.0570576670541667 351 3674992
SGTC_256 clotrimazole 625 nM 1.57337273494433 0.0596946140174025 no 309 0.0578162682124021 389 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C
SGTC_1218 1348-1416 30.7 µM 1.56889335824227 0.0602328869413604 no 310 0.058336394871005 384 6787668
SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM 1.5678060306289 0.0603641191122688 no 311 0.0584632035379084 284 4620898
SGTC_207 4185-0010 4.486 µM 1.56659185527387 0.0605109251673305 no 312 0.0586050614160208 476 3761753
SGTC_1175 0741-0056 27.6 µM 1.56356291282987 0.0608783725502363 no 313 0.0589601251199424 446 765927
SGTC_3304 9125678 46.087 µM 1.56036830577663 0.0612678050046976 no 314 0.0593364350808506 419 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2
SGTC_203 k066-0004 30.888 µM 1.55471546897154 0.061961669505748 no 315 0.0600069244097195 488 6795412
SGTC_926 2268-1401 59.4 µM 1.55208570676078 0.0622865458702429 no 316 0.0603208587597471 408 2931578
SGTC_138 0850-0259 40.9225 µM 1.53632625848387 0.0642613538568937 no 317 0.0622291912369809 584 6813004
SGTC_741 4582-0002 126 µM 1.53568266440489 0.0643430247791358 no 318 0.0623081144073827 397 2912688
SGTC_205 1486-1330 71.903 µM 1.53294536650377 0.064691284281494 no 319 0.0626446583358769 323 4118834
SGTC_1977 st070720 65.3 µM 1.52916111921594 0.0651751531581554 no 320 0.0631122533334849 354 682188
SGTC_1152 3909-8331 15.9 µM 1.52578399815058 0.0656093323847025 no 321 0.0635318335643941 372 16001939
SGTC_8 0354-0001 70 µM 1.5237483765218 0.0658721231438547 no 322 0.0637857898764501 515 4993152
SGTC_715 0868-0130 184 µM 1.52259233962106 0.0660217257291293 no 323 0.0639303637395431 355 2876258
SGTC_578 3460-0051 92 µM 1.51964713509651 0.0664040539123996 no 324 0.0642998423517654 454 2876744
SGTC_2100 5377183 190 µM 1.51561353826892 0.0669304492400625 no 325 0.0648085508720274 431 2844202
SGTC_1857 st056007 79.3 µM 1.51363095907502 0.0671903616038863 no 326 0.065059732250068 361 619834
SGTC_821 1114-0266 29.2 µM 1.50947094429134 0.067738267696864 no 327 0.0655892375426719 401 3123235
SGTC_695 3505-6186 243 µM 1.50059173761996 0.0689192662732846 no 328 0.0667305948427349 425 1819379
SGTC_2815 7968870 71.43 µM 1.49101301866175 0.0702110348520932 no 329 0.0679790384768146 472 2977326 YHR190W ERG9
SGTC_2926 9010726 65.15 µM 1.49042815901767 0.0702905071322924 no 330 0.0680558465259434 439 2994293
SGTC_1055 3448-0672 86 µM 1.48843650124731 0.0705616578176645 no 331 0.0683179082218257 417 748378
SGTC_1315 1237-0019 3.69 µM 1.48626830294468 0.0708577565679527 no 332 0.068604083632432 437 825140
SGTC_647 0140-0236 81 µM 1.48380575798663 0.0711952093011855 no 333 0.0689302295595395 478 990837
SGTC_2562 3',7'-dimethoxyflavone 64.92 µM 1.48164415166151 0.0714924388925882 no 334 0.0692175022620627 507 688664
SGTC_682 0kpi-0099 17 µM 1.47708971730177 0.0721218077633828 no 335 0.0698257947624873 487 1714895 YML126C ERG13
SGTC_2046 4110841 106 µM 1.47458454192705 0.0724697991860874 no 336 0.0701621366547848 419 44119630 YMR134W ERG29
SGTC_1475 4092-1048 11.7 µM 1.47001273572079 0.0731081779724854 no 337 0.0707791523612079 468 2881759
SGTC_1894 3',6'-dihydroxyflavone 78.7 µM 1.46814775623277 0.0733698245240494 no 338 0.0710320458946481 432 688662
SGTC_1641 st009299 47.1 µM 1.46675148319039 0.0735661824896462 no 339 0.0712218360887735 350 4046054
SGTC_70 0141-0289 43.283 µM 1.4587829189212 0.0746945003148376 no 340 0.0723124326763448 687 352408
SGTC_1791 st048313 56.1 µM 1.45641961811275 0.0750316609064961 no 341 0.0726383277820621 388 1204976
SGTC_202 3594-0513 34.79 µM 1.45635520124243 0.0750408671700053 no 342 0.0726472264792601 394 708429
SGTC_3224 9130643 49.47 µM 1.44935285531955 0.0760467666172756 no 343 0.0736195337008805 443 17644395
SGTC_2366 9070441 60.58 µM 1.44922585034829 0.0760651054276141 no 344 0.0736372603282953 469 6837235
SGTC_1279 0874-0590 65.2 µM 1.44557483322036 0.076593732651676 no 345 0.074148244836541 448 3523074
SGTC_379 3970-0972 5.9 µM 1.44383490062668 0.0768466368239089 no 346 0.0743927110663211 453 2898042 YBL034C STU1
SGTC_2692 st077426 47.7 µM 1.44182673347461 0.0771393182946545 no 347 0.0746756295989582 475 25238571
SGTC_1537 2',6'-dihydroxyflavanone 78 µM 1.43783971083936 0.0777229183976207 no 348 0.0752397695429639 505 5106787 A p450 inhibitor.
SGTC_321 4534-3890 65.3 µM 1.43666974080781 0.0778948071307195 no 349 0.0754059284110795 439 699746
SGTC_3057 9095946 49.47 µM 1.43173991506662 0.0786222532329259 no 350 0.0761091342942695 443 24540043
SGTC_805 3852-0218 479 µM 1.43056201743459 0.0787968237393035 no 351 0.0762778898823772 475 6615355
SGTC_2691 st077356 60.2 µM 1.42849054862346 0.0791045382547663 no 352 0.0765753565454068 471 2839272
SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM 1.42719136073217 0.0792979950701974 no 353 0.0767623720065152 443 521171
SGTC_522 1273-0010 11.6 µM 1.42609347395708 0.0794617559859548 no 354 0.0769206811495449 448 5705015
SGTC_1642 st009582 77.7 µM 1.42249113357113 0.0800008792663207 no 355 0.0774418618211289 424 6739311
SGTC_3002 9075603 71.4286 µM 1.42246613847225 0.0800046296494516 no 356 0.0774454874164177 477 20105405
SGTC_1245 0418-0076 17.2 µM 1.41940865234709 0.0804643927209297 no 357 0.0778899556791492 476 6790114
SGTC_2451 5856223 45.7 µM 1.4147546787584 0.0811680518892404 no 358 0.0785702182260614 456 2179896
SGTC_1614 st002383 48.6 µM 1.41414102091744 0.0812611795208089 no 359 0.0786602504484749 481 1947235
SGTC_2168 5727979 200 µM 1.41343683352993 0.0813681450575134 no 360 0.0787636609395756 435 695210
SGTC_2221 6807166 181.081 µM 1.40808814459924 0.0821840764260522 no 361 0.0795524855456287 376 674925
SGTC_3344 9148862 3.898 µM 1.40768561777694 0.0822457295131833 no 362 0.0796120912018271 463 4905352
SGTC_1817 st052116 64.4 µM 1.40656501233023 0.0824175507007181 no 363 0.0797782069938658 454 4361398
SGTC_3202 9113761 49.47 µM 1.40424526562177 0.0827740934884949 no 364 0.0801229134366796 557 4798415
SGTC_1177 0983-0204 23.6 µM 1.40407529337829 0.0828002636199824 no 365 0.080148214933904 511 766818
SGTC_948 3448-0295 75.3 µM 1.40200943492271 0.0831188356650655 no 366 0.0804562146426116 538 678569
SGTC_179 1273-0063 6.77 µM 1.39888173035624 0.0836029058392089 no 367 0.0809242260136816 422 3108139
SGTC_1602 st001878 87.6 µM 1.39875424594806 0.083622681245329 no 368 0.0809433455308353 455 595405 YLR310C CDC25
SGTC_1888 azatryptophan 97.5 µM 1.39654597690252 0.0839657862990865 no 369 0.0812750727472359 426 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides
SGTC_2224 6650123 117.647 µM 1.39579652213201 0.084082471160783 no 370 0.081387888996171 425 2908370
SGTC_1591 genipin 88.4 µM 1.39554138686714 0.0841222216984101 no 371 0.0814263217249713 430 442424 A DNA cross-linking agent.
SGTC_1285 0929-0069 65.5 µM 1.39553567052571 0.0841231124763383 no 372 0.081427182972406 486 1206237
SGTC_2190 6049624 200 µM 1.39084174282678 0.084856960206622 no 373 0.082136710942343 405 2265554
SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM 1.39060908102354 0.0848934589613096 no 374 0.0821720005596756 523 6708561
SGTC_678 1218-2179 85.9 µM 1.38909270529591 0.0851316283468278 no 375 0.0824022808407522 415 6820081 YOR116C RPO31
SGTC_3105 9121040 49.47 µM 1.38445142025849 0.0858637229790047 no 376 0.0831101366919175 251 41448907
SGTC_1131 3454-3128 32.3 µM 1.38401593202924 0.0859326559190268 no 377 0.0831767882088964 545 710982
SGTC_868 0527-0199 213 µM 1.38343080044916 0.0860253409296142 no 378 0.0832664059270655 515 2849450
SGTC_2194 5927483 104.545 µM 1.38103127547112 0.0864062087660197 no 379 0.0836346722702462 525 760979
SGTC_319 1348-1596 45.5 µM 1.37863581027873 0.0867876884600959 no 380 0.0840035348292019 509 5380505
SGTC_1615 st002656 86.5 µM 1.37505971001783 0.0873595249304747 no 381 0.0845564669461528 473 1584458
SGTC_3184 9108758 49.47 µM 1.3710960863666 0.0879966094370593 no 382 0.0851725024132662 470 902885
SGTC_3095 9117207 49.47 µM 1.36826683922856 0.0884534769891442 no 383 0.0856142833011935 429 17015229
SGTC_2936 9038235 15.59 µM 1.36622705528109 0.088783956594428 no 384 0.0859338540493387 492 4749415
SGTC_1725 st036284 20.55 µM 1.36428266553025 0.0890998358354664 no 385 0.08623930971271 551 707914
SGTC_1220 1838-0075 193 µM 1.35946482116667 0.0898861298276078 no 386 0.0869996713255904 519 5529645
SGTC_1961 st076550 68.7 µM 1.35851864720836 0.0900411537175823 no 387 0.0871495848572096 451 1579337
SGTC_1604 st002052 72.4 µM 1.35768679018201 0.0901776116174138 no 388 0.0872815450855334 509 6254834 YHR062C RPP1
SGTC_1766 st045414 44.774 µM 1.35551239797917 0.0905350246029546 no 389 0.0876271806231914 539 253960
SGTC_2772 vinpocetine 57.06 µM 1.35162238288864 0.0911770627915264 no 390 0.0882480731282241 495 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor.
SGTC_3201 9113999 49.47 µM 1.35121624959545 0.0912442883375497 no 391 0.088313085383992 503 16649224
SGTC_1975 st070967 30.8 µM 1.34928054490895 0.091565202510333 no 392 0.0886234360833807 560 261391
SGTC_1745 st081495 74 µM 1.34895911078931 0.0916185729038496 no 393 0.0886750500301647 574 13842402 YBL026W LSM2
SGTC_2739 tacrine 100.86 µM 1.34809483399938 0.0917621903113073 no 394 0.0888139413937829 473 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders.
SGTC_1850 st056238 17 µM 1.34285343873428 0.0926367303053413 no 395 0.0896597178447608 576 5393177
SGTC_1886 st057356 49.9 µM 1.3417650043199 0.0928191088489311 no 396 0.0898361012578294 491 24207747
SGTC_755 1995-0008 37.3 µM 1.33640906724465 0.093720420807598 no 397 0.0907078021298576 531 689533
SGTC_1040 k898-0338 155 µM 1.33552217711672 0.0938702906057017 no 398 0.0908527509225251 561 20969351
SGTC_1531 st059297 52.4 µM 1.3245539483225 0.0957383825650609 no 399 0.0926595693062662 537 7566702
SGTC_3222 9128301 49.47 µM 1.32350874921369 0.0959178165972712 no 400 0.0928331243277472 518 4911358
SGTC_3019 9081971 49.47 µM 1.32260759003989 0.0960727210960492 no 401 0.0929829544205705 561 16451803
SGTC_1768 st044301 37.178 µM 1.32228911874967 0.0961275085921771 no 402 0.0930359473753104 546 3931349
SGTC_1571 st070080 73.4 µM 1.3208157885588 0.0963812686118103 no 403 0.0932813969785261 526 4315245
SGTC_2066 5222451 176 µM 1.31994286478523 0.096531849274231 no 404 0.0934270473368791 598 2281147
SGTC_3151 9099821 49.47 µM 1.31964341180116 0.0965835451587847 no 405 0.0934770507831985 483 17174189
SGTC_2485 5633444 17.78 µM 1.31858367121547 0.0967666561706613 no 406 0.0936541678060931 530 5724239
SGTC_336 4111-0029 111 µM 1.31641032051377 0.097142983541366 no 407 0.0940181801585388 469 3131175
SGTC_214 4373-3496 70 µM 1.31485236592664 0.0974134119477301 no 408 0.0942797621305562 710 3779166
SGTC_3145 9085516 49.47 µM 1.31409913555065 0.0975443548831623 no 409 0.094406422514145 522 25236195
SGTC_581 0958-0271 211 µM 1.31044087500749 0.0981821497006359 no 410 0.0950233667485862 647 4591145
SGTC_3205 9113483 49.47 µM 1.30984865928598 0.0982856854521312 no 411 0.0951235191244387 577 17018033
SGTC_1493 4348-0038 111 µM 1.30873742542563 0.0984801757466561 no 412 0.0953116548470261 587 800424
SGTC_1460 k062-0059 9.15 µM 1.30854901548797 0.0985131795371491 no 413 0.0953435804419584 525 1373085
SGTC_95 0471-0001 561.058 µM 1.30793655987768 0.0986205194017958 no 414 0.0954474139102105 552 4015405
SGTC_910 3454-3003 490 µM 1.30411977722498 0.0992913840406048 no 415 0.0960963733484159 580 820824
SGTC_3175 9106517 49.47 µM 1.30357068085184 0.0993881709739787 no 416 0.0961900013268873 503 41468073
SGTC_1770 st043884 66.3 µM 1.30273803026401 0.0995350703882192 no 417 0.096332106855599 549 670149
SGTC_3265 9137266 49.47 µM 1.30242114485198 0.0995910181953318 no 418 0.0963862290803955 468 17224265
SGTC_2625 euphol 100 µM 1.29778514354947 0.100412157868587 no 419 0.0971805880624893 596 6708538 A triterpene alcohol.
SGTC_720 r052-1644 49.9 µM 1.29680301114024 0.100586747896313 no 420 0.0973494871917156 477 1422863 YOR257W CDC31
SGTC_2067 5224629 34.075 µM 1.2966441030888 0.100615017190885 no 421 0.0973768351320363 542 2835000
SGTC_1607 st000305 50.6 µM 1.29561828108167 0.10079764750651 no 422 0.0975535138607726 562 5457690
SGTC_823 0417-1665 178 µM 1.28947231015102 0.101896898550054 no 423 0.0986169683758229 562 3429856
SGTC_1327 1436-0082 2.18 µM 1.28931991521422 0.10192426589771 no 424 0.0986434450921962 546 15992205
SGTC_2756 carbadox 75.1 µM 1.28859337251013 0.102054813245932 no 425 0.0987697443468979 574 2553 A substituted quinoxaline antibiotic. YLR208W SEC13
SGTC_971 1315-0384 26.7 µM 1.28797741519717 0.102165585543603 no 426 0.0988769125415792 557 6769120
SGTC_585 0kpi-0023 191 µM 1.28687756329374 0.10236359777515 no 427 0.0990684833594513 501 64601
SGTC_3251 9135047 49.47 µM 1.2857330737984 0.102569942508288 no 428 0.0992681171772205 485 17682963
SGTC_2369 9071472 200 µM 1.28555054950135 0.102602878504335 no 429 0.0992999821486603 557 17296037
SGTC_1485 3909-9022 254 µM 1.28551913631844 0.102608547700166 no 430 0.0993054669956289 560 714516
SGTC_767 0929-0023 86 µM 1.28499326397827 0.102703486678164 no 431 0.0993973189609287 652 1204563
SGTC_3351 9150312 21.596 µM 1.28330577129156 0.103008571254391 no 432 0.0996924857670211 562 4904905
SGTC_1355 1499-0035 1.68 µM 1.28157768210584 0.103321677045334 no 433 0.0999954166637692 550 1548538
SGTC_2583 asiatic acid 100 µM 1.28029514679235 0.103554500944698 no 434 0.100220676952713 525 5320556 A kinase inhibitor; arrests cells at G2/M.
SGTC_2713 st079149 53.4 µM 1.27983402640432 0.103638303004605 no 435 0.100301757085057 595 3103253
SGTC_2525 harmine 47.85 µM 1.27856088959235 0.103869932940132 no 436 0.100525864956833 496 5280953 A monoamine oxidase inhibitor
SGTC_2730 imipramine 71.33 µM 1.2766199390014 0.104223784716815 no 437 0.100868229491441 661 3696 A tricyclic antidepressant.
SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM 1.27577325971937 0.104378414951884 no 438 0.101017841386787 634 688788
SGTC_355 1311-2252 105 µM 1.27400781460658 0.104701375276957 no 439 0.101330323344832 572 5338538
SGTC_1970 st070122 35.8 µM 1.2736443900013 0.104767947802861 no 440 0.101394736434165 569 102928
SGTC_3255 9139072 49.47 µM 1.27211136888614 0.105049105694256 no 441 0.101666776166958 573 17646060
SGTC_1015 4130-4525 82 µM 1.27205352549931 0.105059724921538 no 442 0.101677051063814 574 1363237
SGTC_553 k007-0256 45.7 µM 1.271408014789 0.105178284272929 no 443 0.101791766397926 573 6287000
SGTC_582 0987-0078 156 µM 1.26919240801153 0.105585955679987 no 444 0.102186224079662 704 1625765
SGTC_340 k038-0059 454 µM 1.26652098487037 0.106079015140505 no 445 0.102663310651687 575 23733424
SGTC_1656 st012921 11 µM 1.26409686064477 0.106527868844383 no 446 0.103097631643419 523 6732821
SGTC_1813 st051246 8.6015 µM 1.25984828761089 0.107317843963046 no 447 0.103862048276931 528 5291959
SGTC_889 0919-1524 82.7 µM 1.25655384764594 0.107933309296432 no 448 0.104457617862648 545 3905452
SGTC_2459 5811157 9.22 µM 1.24926922470172 0.109303233224678 no 449 0.105783310076237 562 2870684 YBR192W RIM2
SGTC_2753 fluvastatin 17.09 µM 1.2485153738666 0.10944571013039 no 450 0.105921190940446 589 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5
SGTC_2728 chlorpromazine 9.18 µM 1.24828239480971 0.109489769863205 no 451 0.105963829548953 486 2726 A thorazine and dopamine antagonist.
SGTC_1809 st050081 57.6 µM 1.24760341080638 0.109618248280777 no 452 0.106088164395471 586 5036894
SGTC_1481 3346-2004 36 µM 1.24152924966121 0.110772428217668 no 453 0.107205149887992 593 2770522
SGTC_1773 st048542 73.5835 µM 1.23762885518198 0.111518136455659 no 454 0.107926855032829 611 3237138
SGTC_316 k060-0003 58.6 µM 1.23762007267276 0.11151981960879 no 455 0.107928484033049 583 6152314
SGTC_600 1495-0418 41.6 µM 1.23650659701081 0.111733362624122 no 456 0.108135157537772 566 5377768
SGTC_223 busulfan 5 mM 1.22980111819529 0.113025528972636 no 457 0.10938579469832 493 2478 A DNA alkylator.
SGTC_614 0462-0418 107 µM 1.22927068627863 0.113128198155114 no 458 0.109485167039492 534 5188303
SGTC_1515 3460-0031 42.1 µM 1.22878572510495 0.113222124343914 no 459 0.10957607750622 510 2876596
SGTC_3352 9151559 45.5865 µM 1.22763989330584 0.113444267453266 no 460 0.109791089595683 572 17159339
SGTC_3326 9140064 16.379 µM 1.22740923252661 0.113489023356457 no 461 0.109834409028739 574 1868434
SGTC_841 0251-0215 91.2 µM 1.22620616792232 0.113722662214614 no 462 0.110060550401699 656 3888614
SGTC_1484 3473-2379 286 µM 1.22347403745412 0.114254523264303 no 463 0.110575352194851 711 671917
SGTC_1562 morin hydrate 59.1 µM 1.22305039957736 0.114337150782814 no 464 0.110655330488539 577 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase.
SGTC_3229 9132204 49.47 µM 1.22229316554588 0.114484949806028 no 465 0.110798391429043 540 17682924
SGTC_1337 1486-1011 40.3 µM 1.21790562976112 0.115343998209388 no 466 0.111629918298433 583 X1337
SGTC_980 1473-0395 201 µM 1.21488113355105 0.115938834492266 no 467 0.11220571522161 546 768876
SGTC_2173 5763948 167 µM 1.21248340122053 0.116411948636236 no 468 0.112663696343374 626 2867177
SGTC_3200 9114385 49.47 µM 1.21122629828543 0.116660543371731 no 469 0.112904343192854 570 17018030 YLR208W SEC13
SGTC_627 1391-0720 175 µM 1.21102820730614 0.11669975058318 no 470 0.112942297131093 599 997839
SGTC_2313 7726885 200 µM 1.21045430877232 0.116813392347243 no 471 0.11305230664879 605 726423
SGTC_2188 6126565 140.678 µM 1.20985550199262 0.116932049976899 no 472 0.11316717227769 561 874518
SGTC_1517 deoxycholic acid methyl ester 49.2 µM 1.20889207249136 0.11712313931441 no 473 0.113352156090294 604 229346 A bile salt which induces apoptosis.
SGTC_1938 st074717 56.4 µM 1.20773179343196 0.117353565888618 no 474 0.113575222259991 550 17250979
SGTC_3327 9140648 26.9345 µM 1.20748790399704 0.117402042118952 no 475 0.113622150314866 588 8029710
SGTC_2642 cholecalciferol 100 µM 1.20722618989737 0.117454077006256 no 476 0.113672523481943 586 9821465 A vitamin D precursor, similar to steriods.
SGTC_1122 capsaicin 818.572 nM 1.20591887239414 0.117714246838595 no 477 0.11392438652809 623 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_196 k015-0023 18.111 µM 1.20265298080905 0.11836597478933 no 478 0.114555318122462 649 5211998
SGTC_1494 4358-1428 177 µM 1.19940958751295 0.119015733456533 no 479 0.11518436071074 642 1564571
SGTC_1079 idarubicin 2.36 µM 1.19929364752749 0.119039006591498 no 480 0.115206892158382 606 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_1758 st042942 75.2445 µM 1.19808942659529 0.119280925096677 no 481 0.11544110233437 626 669317
SGTC_3300 9124615 50.48 µM 1.19732241841896 0.119435191768277 no 482 0.115590454821941 608 24824903
SGTC_1840 st055363 71 µM 1.19404620390459 0.120095714258729 no 483 0.116229947451977 562 676033
SGTC_2373 9071805 200 µM 1.19355345986127 0.120195279395897 no 484 0.116326344184795 625 10149009
SGTC_1432 4049-0298 68.4 µM 1.1920053037778 0.120508482211181 no 485 0.116629582816929 611 741646
SGTC_1919 st067113 52.3 µM 1.1911369953925 0.120684398434904 no 486 0.116799904263174 650 1268243
SGTC_1647 st011722 22.4 µM 1.19013411130754 0.120887804110013 no 487 0.116996842505094 590 2854783
SGTC_2502 avocadyne acetate 18.59 µM 1.18917364837533 0.121082831947139 no 488 0.11718567091057 697 3952079
SGTC_2425 5628681 7.85 µM 1.18810821691143 0.121299433110247 no 489 0.117395388744543 720 5714958
SGTC_2972 9093619 59.92 µM 1.18451112198399 0.122032731276906 no 490 0.118105398141119 613 25236256
SGTC_2545 solidagenone 89.61 µM 1.18229781345686 0.122485477033432 no 491 0.118543776437307 399 6708572 An anti ulcer agent
SGTC_1352 1496-0991 99 µM 1.18059267752128 0.12283507585384 no 492 0.118882286965667 632 3000039
SGTC_1141 3253-0389 52.6 µM 1.17736910899108 0.123497904808567 no 493 0.119524106988684 622 5402031
SGTC_2170 morpholine 200 µM 1.17540993533544 0.123901971205135 no 494 0.119915375257148 656 121171 Reacts with secondary amines.
SGTC_2962 9082311 13.18 µM 1.17247158395441 0.124509719470825 no 495 0.120503887127813 597 16459453
SGTC_2159 5658611 73.75 µM 1.16979029578404 0.125066114494175 no 496 0.121042684925748 628 793844
SGTC_1953 st076800 12.1 µM 1.16974471843415 0.125075587251956 no 497 0.121051858200484 653 297591
SGTC_857 0438-0306 1.35 µM 1.16930059922834 0.125167918843892 no 498 0.121141270911459 647 4686136
SGTC_1096 rimcazole 32.2 µM 1.16850830004661 0.125332754606348 no 499 0.121300896618764 609 18528119 A dopamine reuptake inhibitor.
SGTC_981 1488-1094 54.9 µM 1.16738924197603 0.125565829777966 no 500 0.121526606829245 582 3449522
SGTC_1316 1272-0050 65.9 µM 1.16551171103593 0.125957557251323 no 501 0.121905961291878 636 7340392
SGTC_3035 9091303 49.47 µM 1.16360744338743 0.126355732699543 no 502 0.122291566779237 643 25237002
SGTC_2386 9075165 157.42 µM 1.16297711678656 0.126487724703614 no 503 0.122419393436673 634 16452277
SGTC_1434 4073-0095 163 µM 1.16270061649513 0.126545654870798 no 504 0.122475495704025 683 24133745
SGTC_892 0929-0076 29 µM 1.16177302430475 0.126740131678833 no 505 0.122663837137698 686 5751038
SGTC_284 0988-0104 32.6 µM 1.15837499038192 0.127454332670699 no 506 0.12335552035148 670 4666532
SGTC_2721 ifenprodil 61.44 µM 1.15628765926721 0.127894434419752 no 507 0.123781757202903 649 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor.
SGTC_2192 5915882 198.485 µM 1.15064839412668 0.129088717228278 no 508 0.124938457549765 603 2876149
SGTC_2069 5228469 200 µM 1.14758390217726 0.129740947674438 no 509 0.125570189204536 632 2835210
SGTC_3271 9137798 49.47 µM 1.13811150191754 0.131771418333396 no 510 0.127536962955749 595 6498326
SGTC_2908 7930301 100 µM 1.13782382602665 0.131833424682227 no 511 0.127597026960125 756 2223178
SGTC_139 0099-0334 718.624 µM 1.13658777715628 0.132100074639908 no 512 0.127855326041649 780 97690
SGTC_2916 7875993 68.79 µM 1.13548119460826 0.132339110428784 no 513 0.128086878410804 677 1299250
SGTC_2466 5983409 37.09 µM 1.13279615505228 0.132920351564787 no 514 0.128649933247883 648 2879657
SGTC_554 4483-2211 187 µM 1.13222413223479 0.133044406372225 no 515 0.128770108455238 664 747107
SGTC_3165 9101544 49.47 µM 1.12871738537924 0.133806657634621 no 516 0.129508536457881 678 5002184
SGTC_903 1134-0042 114 µM 1.12613239843401 0.134370467099241 no 517 0.130054741169704 664 701009
SGTC_374 0880-0231 82.3 µM 1.12101239942585 0.135491995826936 no 518 0.131141292247511 685 6833587
SGTC_2775 cyproheptadine 69.59 µM 1.11544226555328 0.136719392252052 no 519 0.132330473081402 703 2913 A selective serotonin reuptake inhibitor.
SGTC_3103 9120822 49.47 µM 1.11354513362259 0.137139161300655 no 520 0.132737187764151 716 17141819
SGTC_31 0508-1974 57.237 µM 1.11323626933609 0.1372075854329 no 521 0.132803484722487 678 6810525
SGTC_1533 dihydroergotamine mesylate 29.4 µM 1.11107255436848 0.13768757706088 no 522 0.133268560200569 735 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release.
SGTC_2624 nerol 100 µM 1.11102011145461 0.137699225036042 no 523 0.133279846332541 674 637566 A natural product oil.
SGTC_3281 9140613 49.47 µM 1.10762550150235 0.138454624848521 no 524 0.134011792652251 642 16013766
SGTC_2332 7982454 138.89 µM 1.10579233732582 0.138863729555577 no 525 0.134408206205642 713 2981748
SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM 1.10502654921433 0.139034872939859 no 526 0.134574042640131 680 689007
SGTC_1276 0871-0068 94.2 µM 1.10494258979661 0.139053645475497 no 527 0.134592233141904 690 3414906
SGTC_2088 5278280 127.392 µM 1.10376992492048 0.13931602265204 no 528 0.134846477086401 729 791502
SGTC_399 oxolinic acid 75 µM 1.10376812874064 0.13931642479538 no 529 0.134846866766371 683 4628 A DNA gyrase inhibitor.
SGTC_1170 0310-0127 64.8 µM 1.10136913467902 0.139854236140766 no 530 0.135368016559992 726 774975
SGTC_3264 9137442 49.47 µM 1.09903094070096 0.140379773486715 no 531 0.135877285150128 668 17015726
SGTC_414 piperonyl butoxide 100 µM 1.09651653848285 0.140946410352998 no 532 0.136426394881651 687 5794 A potent inhibitor of cytochrome P450.
SGTC_1832 st054113 55 µM 1.09203608219189 0.141959951021842 no 533 0.137408620937342 683 1251267
SGTC_2626 ethyl orsellinate 100 µM 1.08959940702601 0.142513226865668 no 534 0.13794482220498 673 75653 A natural product.
SGTC_836 0330-0104 1.35 µM 1.08955421439376 0.142523502142187 no 535 0.13795478050846 716 46494820
SGTC_489 paxilline 115 µM 1.08837600915051 0.142791562989305 no 536 0.138214573869429 675 105008 A toxic potassium channel blocker.
SGTC_2569 tetrandrine 100 µM 1.08475834207531 0.14361676975256 no 537 0.13901435019412 637 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_542 3381-0244 89.3 µM 1.08355274707918 0.143892485230562 no 538 0.139281575822533 794 1112843
SGTC_354 2783-3500 4.88 µM 1.08341620498119 0.143923734439113 no 539 0.139311863021269 702 6740761
SGTC_2354 9060492 162 µM 1.08139934770553 0.144385848299054 no 540 0.139759755846089 795 6471895
SGTC_342 k048-0088 23.3 µM 1.08060716448472 0.144567631064821 no 541 0.139935947114244 706 6820570
SGTC_2064 5220758 200 µM 1.07807832416509 0.145148956963512 no 542 0.140499401981032 764 788518
SGTC_532 1548-0774 215 µM 1.07794748371928 0.145179077104321 no 543 0.140528596592876 748 5932993
SGTC_2943 9068529 45.32 µM 1.07473077636091 0.145920902473561 no 544 0.141247640289156 782 3270634
SGTC_2166 5933061 31.504 µM 1.0734340062074 0.146220678052377 no 545 0.14153821680656 691 2877375
SGTC_2819 7996655 46.38 µM 1.07343010654444 0.146221580164463 no 546 0.141539091242192 640 6456960
SGTC_2667 digitoxin 100 µM 1.07303199988159 0.146313694159056 no 547 0.14162837941069 644 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_1792 st045773 43.6 µM 1.07285951727339 0.146353615312842 no 548 0.141667076004307 707 2919270
SGTC_2378 9074213 121.43 µM 1.07154721551372 0.146657587451398 no 549 0.141961726351877 744 657714
SGTC_1706 st031321 9.9705 µM 1.07001479626206 0.147013081870296 no 550 0.142306324336517 755 6103185
SGTC_302 1094-0063 18.9 µM 1.06683504391364 0.147752570853149 no 551 0.143023165449555 666 5440289
SGTC_2311 7694451 200 µM 1.06643539203808 0.147845690522034 no 552 0.143113434980276 726 2163142
SGTC_1540 guanosine 70.6 µM 1.06641862998428 0.147849596971744 no 553 0.143117221872963 704 6802 Guanosine is a purine nucleoside
SGTC_2301 7769476 200 µM 1.06483286451177 0.148219477170637 no 554 0.143475785054133 685 977820
SGTC_3110 9122132 49.47 µM 1.06380142759027 0.148460392116724 no 555 0.143709332244654 761 918317
SGTC_2135 5326629 150.42 µM 1.06301488747508 0.148644281876883 no 556 0.143887600013858 669 5020077
SGTC_1629 st005085 44.9 µM 1.06191609198542 0.148901430468137 no 557 0.144136889512001 727 24207091
SGTC_1838 st055369 84.5 µM 1.06146804939169 0.149006370112375 no 558 0.144238622818256 708 676036
SGTC_2639 lactacystin 53 µM 1.06029139735874 0.149282198413092 no 559 0.144506025850651 769 3870 A proteasome inhibitor.
SGTC_2714 st079313 56.9 µM 1.05901200994469 0.149582496356771 no 560 0.144797155083647 724 2939799
SGTC_3160 9100216 49.47 µM 1.05479629211312 0.150574860955507 no 561 0.145759250394245 754 17191039
SGTC_909 3448-9333 149 µM 1.05222505089967 0.151182269748619 no 562 0.1463481543772 709 3344074
SGTC_3139 9095020 49.47 µM 1.05052363686753 0.151585092710683 no 563 0.14673871470343 590 25236292
SGTC_154 3389-1638 511.116 µM 1.04874129340377 0.152007840862626 no 564 0.147148601761812 661 5238686
SGTC_1909 st060837 51.5 µM 1.04578225149615 0.152711413887831 no 565 0.147830788689048 715 678937
SGTC_3333 9141820 12.094 µM 1.04470993105856 0.152966912490844 no 566 0.148078526751498 699 1939433
SGTC_338 4055-0136 114 µM 1.04443935679166 0.153031426168435 no 567 0.148141081364826 743 2900563
SGTC_2395 5646831 180.19 µM 1.04292360873342 0.153393163138877 no 568 0.148491837187859 764 6808628
SGTC_516 3992-2719 87.3 µM 1.04097250593848 0.153859631754459 no 569 0.148944154354948 707 5350887 YDR037W KRS1
SGTC_3028 9087778 49.47 µM 1.04061309976217 0.153945660682528 no 570 0.149027574497471 766 17217395
SGTC_345 1362-0200 395 µM 1.03933898690596 0.154250893919757 no 571 0.149323554473453 716 1419823
SGTC_2560 caryophyllene 100 µM 1.03907584932307 0.154313982386963 no 572 0.149384730932677 829 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor.
SGTC_733 4069-0007 56.1 µM 1.03878864652759 0.154382860073321 no 573 0.149451521370897 815 5717425 YNL287W SEC21
SGTC_2272 7805186 180 µM 1.03816724207432 0.154531956386943 no 574 0.149596100275494 776 2956062 YPR165W RHO1
SGTC_2757 clomiphene 4.22 µM 1.03070375690818 0.15633013772553 no 575 0.151339881222222 858 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined.
SGTC_2909 7941780 10.49 µM 1.03024538337713 0.156441021311618 no 576 0.151447415210666 799 1243215
SGTC_1251 0490-5699 265 µM 1.03010826558878 0.156474201072106 no 577 0.151479592781356 836 3883818
SGTC_1252 0493-0875 34.8 µM 1.02863122984918 0.156831907945337 no 578 0.151826498456389 736 3960963
SGTC_1037 k284-1091 78.7 µM 1.02796200489067 0.156994157094318 no 579 0.151983850366973 726 3334711
SGTC_1300 1094-0077 113 µM 1.02621222947033 0.157418900117316 no 580 0.152395779047195 733 5532636
SGTC_3015 9080845 49.47 µM 1.02557543375254 0.157573664112036 no 581 0.152545875979497 832 5296973
SGTC_1506 4226-2149 212 µM 1.02441365581465 0.157856274943007 no 582 0.152819967310866 838 991114
SGTC_599 1935-0052 86.5 µM 1.02347822584166 0.158084066759829 no 583 0.153040894925315 796 9557311
SGTC_1069 diphenylcyclopropenone 8.49 µM 1.02156085689441 0.158551650127507 no 584 0.15349439596077 862 65057 A dermal irritant. YDR527W RBA50
SGTC_921 1561-0023 372 µM 1.02112939773799 0.158656993744502 no 585 0.153596568340454 809 24050882
SGTC_706 4262-0057 46.9 µM 1.01859890792123 0.159275753283347 no 586 0.154196711483697 756 883298
SGTC_1906 st060206 94.7 µM 1.01821873286064 0.159368850679977 no 587 0.154287009458856 843 5133468
SGTC_1328 1441-0025 69.2 µM 1.01809188834507 0.159399920332965 no 588 0.15431714494437 735 4562601
SGTC_2547 epiafzelechin trimethyl ether 100 µM 1.01692333270854 0.159686336184072 no 589 0.154594951316127 613 6708630 An antioxidant.
SGTC_1307 1187-1599 12.2 µM 1.01640092440974 0.159814488597757 no 590 0.154719252806566 785 1538471
SGTC_1173 0443-0020 122 µM 1.01508140702851 0.16013848000692 no 591 0.155033511886072 770 5331295
SGTC_2665 lovastatin 100 µM 1.01468639407986 0.160235554079774 no 592 0.155127670933553 758 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1
SGTC_2310 7668677 200 µM 1.01354268756243 0.160516835777085 no 593 0.155400508579752 766 2197143
SGTC_3174 9107204 49.47 µM 1.01327575945973 0.160582530127805 no 594 0.155464231332424 763 3938802
SGTC_1026 k007-1105 30.6 µM 1.01137032197925 0.161051992229515 no 595 0.155919610046282 840 7066794
SGTC_140 0062-0056 502.533 µM 1.01100636853373 0.161141764934464 no 596 0.156006690852498 844 3758964
SGTC_721 1187-1332 279 µM 1.00970052558336 0.161464132648935 no 597 0.156319395296006 707 25730
SGTC_1339 1486-1321 22.7 µM 1.0095828059763 0.161493214220323 no 598 0.156347605363161 795 3469382
SGTC_596 1155-0152 116 µM 1.00687944405861 0.162161995172778 no 599 0.156996355667264 828 280313
SGTC_1862 st057513 3.81 µM 1.00370762967436 0.162948961882744 no 600 0.157759779216531 788 5393163
SGTC_3225 9130819 49.47 µM 1.0014900543263 0.163500642346812 no 601 0.15829497302564 808 4547121
SGTC_108 0509-0257 621.132 µM 1.00039452222156 0.163773632023738 no 602 0.15855980993477 822 536624
SGTC_1816 st051957 91.6 µM 0.998660906679137 0.164206226379356 no 603 0.158979492259874 806 674121
SGTC_1140 3229-1848 2.98 µM 0.994190236719875 0.165325222470808 no 604 0.160065130199835 830 2849525
SGTC_98 0074-0023 107.663 µM 0.990116562028453 0.166349137940319 no 605 0.161058574519424 840 3563821
SGTC_2768 sulfasalazine 50.2 µM 0.990020959039956 0.16637321676448 no 606 0.161081937376843 822 5384001 An antioxidant and salicylic acid derivative.
SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM 0.989903091509243 0.166402906293346 no 607 0.161110744146983 781 4330530
SGTC_2432 5630864 12.22 µM 0.988981094514259 0.166635265180035 no 608 0.16133619576973 778 5714970
SGTC_1124 fisetin 1.16336 µM 0.987450176031638 0.167021544880918 no 609 0.161710998390697 752 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster.
SGTC_1518 st038567 90.8 µM 0.986737365422769 0.167201597351783 no 610 0.161885703623465 810 77966
SGTC_672 1441-0018 53.7 µM 0.985305259602128 0.167563718345247 no 611 0.162237074991221 763 251141
SGTC_2394 5221648 200 µM 0.984456395831113 0.167778599572591 no 612 0.162445580415945 911 788586
SGTC_2123 5259487 200 µM 0.982656685510536 0.16823476451176 no 613 0.162888217727967 857 2173474
SGTC_2493 resveratrol 26.09 µM 0.979662895494247 0.168995353490519 no 614 0.163626273662137 759 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase.
SGTC_1488 4013-0813 75.9 µM 0.979263160281184 0.169097075323627 no 615 0.163724984023136 788 2910057
SGTC_3054 9094397 49.47 µM 0.978410515948176 0.169314181667843 no 616 0.16393566461167 833 2598354
SGTC_954 1189-0853 2.85 µM 0.975805860881439 0.169978504976222 no 617 0.164580339913151 852 2828194
SGTC_1158 4092-0494 91.8 µM 0.97524392094796 0.170122047891434 no 618 0.164719640211703 855 1148199
SGTC_610 4215-0184 155 µM 0.975181004563491 0.170138124196526 no 619 0.16473524142064 864 5605015
SGTC_3011 9081274 71.4286 µM 0.974593841385858 0.170288202231627 no 620 0.164880884867395 853 6625322
SGTC_1189 1431-2119 7.28 µM 0.973392325089466 0.170595572255359 no 621 0.165179175956575 857 3107275
SGTC_2274 7947094 46.08 µM 0.968329587508422 0.171894612398279 no 622 0.166439896311869 883 2971028
SGTC_396 dithiazanine 1.25 µM 0.968008806743987 0.171977133283317 no 623 0.166519985717604 793 10578 An antihelmenthic.
SGTC_687 k029-0044 34.9 µM 0.967439376617418 0.172123681527806 no 624 0.166662216730899 899 5829338
SGTC_1111 tnp00062 510.699 nM 0.967201755244145 0.172184859204625 no 625 0.166721592455513 875 676306
SGTC_1344 1488-0097 29.1 µM 0.966993522160984 0.172238482018769 no 626 0.166773635991026 821 747966
SGTC_619 1652-1634 108 µM 0.966364869554388 0.172400433139904 no 627 0.166930818238055 787 5400454
SGTC_1764 st044502 93.5 µM 0.965404674725337 0.172647982339658 no 628 0.167171080474454 834 8407
SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM 0.965403991247751 0.172648158628664 no 629 0.167171251575204 838 6312947
SGTC_1613 st002381 52.1 µM 0.965087123790945 0.17272990044136 no 630 0.167250587856417 865 551167
SGTC_435 c-PAF 6.7 µM 0.963779168770325 0.173067572626334 no 631 0.167578326331576 856 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase
SGTC_800 3448-7362 155 µM 0.963071318164557 0.173250492274293 no 632 0.16775586712916 1033 15991913
SGTC_1162 k048-0130 20.1 µM 0.961678408282997 0.173610801263946 no 633 0.168105585805729 828 6797406
SGTC_2205 7238770 200 µM 0.960813911041687 0.173834663477421 no 634 0.168322871377808 849 279867
SGTC_2537 larixol 68.93 µM 0.958348556946811 0.174474076543174 no 635 0.168943513175138 894 6708759
SGTC_416 estradiol valerate 100 µM 0.95730244517751 0.174745846450237 no 636 0.16920731076677 836 13791 A steroid.
SGTC_457 grayanotoxin iii 135 µM 0.955388316676029 0.175243814152545 no 637 0.16969068004724 874 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity.
SGTC_1470 k295-0292 231 µM 0.955049959235365 0.175331932614652 no 638 0.169776216490243 871 5045612
SGTC_1551 6-bromo-3'-methylflavone 63.5 µM 0.95225904087263 0.176059843012961 no 639 0.17048281241506 876 688751
SGTC_3269 9137823 49.47 µM 0.948163847900644 0.177131384181396 no 640 0.171523024213146 782 17682936
SGTC_1821 st053465 65.6 µM 0.947296483108465 0.177358864945691 no 641 0.171743861212701 811 675086
SGTC_2823 7987624 58.44 µM 0.946549241004083 0.177554989384895 no 642 0.171934259713034 845 2239440
SGTC_3226 9131256 49.47 µM 0.945855042410471 0.177737314389395 no 643 0.172111263352748 773 17178073
SGTC_2137 5261020 140 µM 0.945323198411525 0.177877078304267 no 644 0.172246949202373 840 763655
SGTC_3009 9080819 71.4286 µM 0.943823621098672 0.178271527135291 no 645 0.172629893885946 861 17027216
SGTC_1669 st015249 58.4 µM 0.943252671777354 0.178421854430911 no 646 0.172775838880322 936 722793
SGTC_2331 7980721 200 µM 0.942130073082298 0.178717660266945 no 647 0.173063024707934 870 2981221
SGTC_288 1315-0019 35.1 µM 0.941776679582598 0.178810843657026 no 648 0.173153493554149 884 6811474
SGTC_1376 2910-0861 41.3 µM 0.938990388900614 0.179546608267139 no 649 0.173867839468724 899 1112859
SGTC_1879 gemcitabine 100 µM 0.937900671587075 0.179834882435818 no 650 0.174147729015763 864 60750 A nucleoside analog which inhibits DNA replication.
SGTC_2185 6113692 200 µM 0.93286809353783 0.181169970787535 no 651 0.175444038994826 800 874150
SGTC_2979 9012552 45.46 µM 0.929272075290668 0.18212774830288 no 652 0.176374051575723 839 17100905
SGTC_2978 9011784 42.97 µM 0.922176562484324 0.184026858676493 no 653 0.178218243120959 997 2994934
SGTC_2592 piperlongumine 83.33 µM 0.922083252592579 0.184051914874591 no 654 0.178242575934882 819 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_1253 0550-0034 176 µM 0.919183271891695 0.184831695637962 no 655 0.178999859650511 820 5969915
SGTC_2017 5132927 60.65 µM 0.918257153971879 0.185081153026256 no 656 0.179242126454857 895 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis
SGTC_2299 7976368 114.88 µM 0.917355928004463 0.185324106254071 no 657 0.179478079555817 882 2979718
SGTC_807 1315-0151 48 µM 0.91707979396588 0.185398586304762 no 658 0.179550414226898 969 4011080
SGTC_2474 5321570 43.32 µM 0.914169068710976 0.186184809417754 no 659 0.180314007221553 900 2841384
SGTC_2980 9014342 25.29 µM 0.912775562383784 0.186561943152825 no 660 0.180680296721859 813 2996599
SGTC_972 1319-0219 195 µM 0.911131513539077 0.187007490643114 no 661 0.181113041923617 868 23903702
SGTC_1697 st025554 27.742 µM 0.909211043673147 0.187528782784273 no 662 0.181619367917813 865 1269519
SGTC_2718 lomofungin 53.02 µM 0.908682507684696 0.187672405961956 no 663 0.181758870099813 879 5351222 A RNA synthesis inhibitor.
SGTC_1826 st055655 41.6 µM 0.908551166469781 0.187708106866054 no 664 0.181793546793833 898 676168
SGTC_1957 st077035 62.4 µM 0.908315269126205 0.187772238539213 no 665 0.181855838776996 927 705593
SGTC_3341 9147222 25.867 µM 0.908263943237325 0.187786193922912 no 666 0.181869393861863 848 1939759
SGTC_1115 galangin 695.678 nM 0.907842485653517 0.187900811434323 no 667 0.181980724031359 984 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_1286 0929-0070 131 µM 0.906806875901123 0.188182634147675 no 668 0.182254466586711 921 1420408
SGTC_1214 0358-0031 63.7 µM 0.900275514759978 0.189966031333347 no 669 0.183986824022321 865 4301366
SGTC_1224 0823-0416 294 µM 0.899433748862284 0.190196630087389 no 670 0.184210834813662 923 3598164
SGTC_1008 4106-0037 6 µM 0.898464146221087 0.190462462306436 no 671 0.184469075797138 924 2905394
SGTC_870 0573-2213 57.6 µM 0.897748505728142 0.190658812965116 no 672 0.184659821646876 901 3916321
SGTC_124 0136-0217 7.121 µM 0.896013740968897 0.191135296658919 no 673 0.185122712211802 1024 3976905
SGTC_1608 st001473 40.5 µM 0.894233668397584 0.191624983204993 no 674 0.185598440862473 867 7292267
SGTC_551 k048-0028 34.9 µM 0.893472702348746 0.19183455433605 no 675 0.18580204211701 961 6836383
SGTC_461 N-acetylfarnesylcysteine 136 µM 0.893012735871829 0.191961297772289 no 676 0.185925176191467 900 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ).
SGTC_973 1325-0077 65.9 µM 0.890780763660975 0.192577043575899 no 677 0.186523398471909 989 2835149
SGTC_3290 9121031 71.43 µM 0.890003867985266 0.192791652758077 no 678 0.186731904572326 863 17014854
SGTC_1744 st037937 38.9 µM 0.889013134314889 0.193065544294378 no 679 0.186998010517949 906 1016152
SGTC_1323 1348-1351 11.2 µM 0.887938281458226 0.193362959394465 no 680 0.187286975632108 890 6989654
SGTC_227 fluconazole 33.516 µM 0.887886611631129 0.193377263633908 no 681 0.187300873580151 950 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C
SGTC_1268 0828-0275 2.46 µM 0.884660371105426 0.194271692164313 no 682 0.188169917650121 970 745337
SGTC_2391 6285546 200 µM 0.884363777933825 0.19435404458611 no 683 0.18824993488666 947 846083
SGTC_2802 7925815 54.55 µM 0.882227043608511 0.19494796075521 no 684 0.188827020112039 914 1262923
SGTC_1497 4476-2978 41.3 µM 0.880336120846135 0.195474471703122 no 685 0.189338625214352 974 1528379
SGTC_3340 9146634 11.102 µM 0.879704428445507 0.195650553208708 no 686 0.18950972487353 918 4907387
SGTC_693 4161-2696 114 µM 0.877484357528662 0.196270151818311 no 687 0.190111805751544 905 805759
SGTC_3089 9117425 49.47 µM 0.874846301928253 0.197007950259846 no 688 0.190828769992849 857 9401657
SGTC_3319 9138450 16.7555 µM 0.874528712477251 0.197096885192521 no 689 0.190915195414298 887 2029690
SGTC_2873 9040596 71.43 µM 0.874356419812285 0.197145142665895 no 690 0.190962091355825 924 6463863
SGTC_3026 9090633 49.47 µM 0.87350803993772 0.197382869746145 no 691 0.191193112950427 966 25236842
SGTC_1559 coumarin 343 70.1 µM 0.872483642513308 0.197670150170883 no 692 0.191472293981159 914 108770 A hepatotoxic, DNA x-linker.
SGTC_2603 homopterocarpin 100 µM 0.870989551133325 0.198089603628243 no 693 0.19187992916853 933 101795 A weak amylase inhibitor.
SGTC_3217 9129673 49.47 µM 0.870248111282295 0.198297955943789 no 694 0.192082414394751 900 17248312
SGTC_2162 5663267 200 µM 0.869665252694126 0.198461838092376 no 695 0.192241683259456 982 6456493
SGTC_2913 7966556 36.57 µM 0.868348555358726 0.198832354102403 no 696 0.192601774271651 920 2976516
SGTC_1999 st074831 12.5 µM 0.868036854423769 0.198920127127742 no 697 0.192687078699791 945 17112523
SGTC_2406 ethylparaben 405.7 µM 0.867062159429391 0.199194745763954 no 698 0.192953976277121 795 8434 A possible steroid mimic.
SGTC_294 k038-0071 157 µM 0.866751589244014 0.199282296329518 no 699 0.193039066115216 954 24152826
SGTC_3286 9117135 37.221 µM 0.865822942935369 0.199544222413481 no 700 0.193293632739768 913 3438150
SGTC_714 4296-0578 26.1 µM 0.86479151909593 0.199835379786291 no 701 0.193576613425963 962 1589775
SGTC_3275 9138069 49.47 µM 0.863838236985883 0.2001047058632 no 702 0.193838379756073 938 17617007
SGTC_1603 st002045 67.8 µM 0.863411812600763 0.200225252030248 no 703 0.193955543494798 976 5887985
SGTC_2504 purpurogallin 52.29 µM 0.860806318848635 0.200962748079429 no 704 0.19467236212345 914 5281571 An antioxidant.
SGTC_475 α-linolenic acid 10 µM 0.860253957478462 0.201119305418013 no 705 0.194824533580547 1023 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_3164 9100705 49.47 µM 0.857492644758604 0.201903048235096 no 706 0.195586339008006 942 17174235
SGTC_1775 st081588 35.1725 µM 0.853160913873034 0.203136199951518 no 707 0.196785037660388 1025 1426443 YGL099W LSG1
SGTC_1692 fluoroquinolonic acid 71 µM 0.852376796240723 0.203359901229153 no 708 0.197002497274281 961 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2
SGTC_2217 6934799 96.0675 µM 0.852304478173869 0.203380540284454 no 709 0.19702256059225 982 675606
SGTC_3097 9117246 49.47 µM 0.852291339376372 0.203384290136761 no 710 0.19702620584279 997 16423892
SGTC_19 0279-0214 38.434 µM 0.850005697019699 0.204037246924413 no 711 0.197660959441154 1075 3566274 YBR002C RER2
SGTC_2059 5238311 157 µM 0.848339717049117 0.204513966005873 no 712 0.19812440229816 932 703021
SGTC_2905 7799065 20.05 µM 0.847487149643696 0.20475818380048 no 713 0.198361823345757 945 1296806
SGTC_380 3970-0968 6 µM 0.847120567903239 0.204863244382558 no 714 0.198463960961409 933 2891601
SGTC_436 n,n-dimethylsphingosine 3.3 µM 0.845968467851083 0.205193639386212 no 715 0.198785167496929 1020 5282309
SGTC_2330 7979373 200 µM 0.845646363903257 0.205286067770279 no 716 0.198875026399056 947 1863007
SGTC_403 arphamenine a 50 µM 0.843290660617582 0.205962793177307 no 717 0.199532952399282 983 5487158 An arginine aminopeptidase inhibitor.
SGTC_2664 lyso-paf C-16 73.48 µM 0.841355373077948 0.206519734069275 no 718 0.200074439141566 1028 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_2681 menadione 3.18 µM 0.839443897720671 0.20707069701044 no 719 0.200610129502711 983 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_1462 k081-0014 26.5 µM 0.839123274966706 0.207163198285079 no 720 0.200700068191914 813 3270634
SGTC_455 paf C-16 10 µM 0.838977704193899 0.207205204250484 no 721 0.200740910601161 933 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis.
SGTC_1748 st037455 53.6035 µM 0.838814662787766 0.207252257529597 no 722 0.200786660622449 961 580690
SGTC_2220 6782180 200 µM 0.837890341743329 0.207519133347969 no 723 0.201046146806146 934 833803
SGTC_1863 st057641 20.1 µM 0.837855157962055 0.207529295842825 no 724 0.201056027979957 1038 3921635
SGTC_1074 carmofur 3.8 µM 0.836314244555381 0.207974662224669 no 725 0.20148907082805 1066 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_398 bronopol 33.3 µM 0.835787842630964 0.208126936081345 no 726 0.201637133526967 989 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them.
SGTC_409 arachidonic acid 100 µM 0.833285987669505 0.208851554137973 no 727 0.202341728531831 1004 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes.
SGTC_296 1222-0039 74.9 µM 0.832437962812018 0.209097506447736 no 728 0.202580890705121 964 5984176
SGTC_1056 3448-1962 115 µM 0.831997380576475 0.209225355631619 no 729 0.202705211521399 942 715507
SGTC_2478 5763493 32.33 µM 0.830451949903057 0.209674175973312 no 730 0.203141652048928 1005 1365576 YLR208W SEC13
SGTC_2195 6536160 144.242 µM 0.829982164748678 0.209810722003294 no 731 0.203274433792522 938 3834386
SGTC_2778 tioconazole 65.09 nM 0.828249659092946 0.210314737406617 no 732 0.203764562892406 961 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_1439 4092-1168 46 µM 0.827350034903896 0.210576733585735 no 733 0.204019345909923 1016 2886240
SGTC_527 4476-4215 268 µM 0.827273204877573 0.210599117550177 no 734 0.204041113773624 980 4418754
SGTC_94 0334-0113 514.748 µM 0.823104087970862 0.21181585670136 no 735 0.205224402153238 1000 6795178
SGTC_724 3910-0327 137 µM 0.820998305551364 0.212431980570095 no 736 0.205823616691454 1028 2885483
SGTC_2014 4013930 200 µM 0.820348079449256 0.212622439429649 no 737 0.206008852447059 1050 64556
SGTC_3246 9135460 32.98 µM 0.820034374086168 0.21271436306371 no 738 0.206098255859551 958 41446951
SGTC_1865 st057639 52.2 µM 0.818103145853481 0.213280772854668 no 739 0.20664914636425 1047 688818
SGTC_2325 6158266 200 µM 0.81747222109743 0.213466007140372 no 740 0.206829308954717 990 3623240
SGTC_1390 3413-2614 145 µM 0.817357659249389 0.213499651606136 no 741 0.20686203242968 1074 3421432
SGTC_1687 st020778 55.3625 µM 0.816804208557505 0.213662232247283 no 742 0.207020163381737 1076 4259299
SGTC_216 k038-0035 28.382 µM 0.816782794370598 0.213668524287777 no 743 0.207026283242204 973 4444231 YPR107C YTH1
SGTC_1929 genistein trimethyl ether 50.5 µM 0.816369877844784 0.213789870920191 no 744 0.207144309658219 1055 136420
SGTC_2180 6301957 200 µM 0.815560994145692 0.214027699446497 no 745 0.207375633076205 1026 845462
SGTC_129 0088-0017 176.636 µM 0.813971596849509 0.214495463410901 no 746 0.207830611290722 980 182446
SGTC_412 gemfibrozil 100 µM 0.811732999418005 0.215155295845353 no 747 0.208472427361643 991 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels.
SGTC_2101 5377231 179.231 µM 0.811281123725099 0.21528863016729 no 748 0.20860212381354 1011 2844213
SGTC_3032 9089427 49.47 µM 0.807800993943268 0.216317112615234 no 749 0.209602576432568 1017 17173707
SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM 0.805439314501271 0.217016676549463 no 750 0.210283106238992 1070 688761
SGTC_1980 st071811 45.7 µM 0.80463358139911 0.217255645248355 no 751 0.210515578791638 1032 4974850
SGTC_1342 1486-1464 234 µM 0.804618470623777 0.217260128335558 no 752 0.210519940038672 1058 3253938
SGTC_796 1234-0020 70.7 µM 0.803459196625456 0.217604222716373 no 753 0.210854685842302 1046 46495034
SGTC_1747 st037496 66.6 µM 0.802776911500305 0.217806884736025 no 754 0.211051844701978 1038 723305
SGTC_1471 k673-0312 37 µM 0.802438232155685 0.217907524506071 no 755 0.211149752459103 1062 24099884
SGTC_2312 7706453 155.7 µM 0.80136086347967 0.218227846707951 no 756 0.211461382570242 1001 976098
SGTC_2431 5490079 200 µM 0.800560845157726 0.218465882816082 no 757 0.211692962930538 1088 5722345
SGTC_2477 5967686 25.23 µM 0.798699951000813 0.219020148175681 no 758 0.212232207604633 1048 776118
SGTC_543 3844-1095 191 µM 0.79824943852875 0.219154454333555 no 759 0.212362876460654 1054 4230703
SGTC_1424 4048-1941 275 µM 0.797556983962345 0.21936098022882 no 760 0.212563811028128 1108 X1424
SGTC_1138 3761-0006 1.03 µM 0.796793438155806 0.219588838820025 no 761 0.212785503335511 1047 12061087
SGTC_2844 9010103 25.97 µM 0.796472799293605 0.219684564907153 no 762 0.212878639704488 1001 2480525
SGTC_1368 1852-0141 284 µM 0.796438123212981 0.219694918816824 no 763 0.212888713534226 994 2838987
SGTC_1558 st069300 45.6 µM 0.794772932715758 0.220192456718455 no 764 0.213372799329972 991 24208000
SGTC_2544 sphondin 68.51 µM 0.79454211427967 0.22026147330926 no 765 0.213439950919007 1035 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31
SGTC_2503 beta-caryophyllene alcohol 24.72 µM 0.793855916570204 0.220466725242189 no 766 0.213639657903337 995 61125 An anti-inflammatory.
SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM 0.792861092522357 0.220764486460687 no 767 0.21392937892866 1081 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis.
SGTC_2202 7226349 200 µM 0.788972286520817 0.221930653988293 no 768 0.215064102187056 1042 844334
SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM 0.787565543906869 0.222353370053278 no 769 0.215475437859359 980 6857784
SGTC_2258 7960471 200 µM 0.787392025806661 0.222405542799784 no 770 0.215526206658001 982 2974708
SGTC_1793 st048256 72.231 µM 0.787206853048639 0.222461227524254 no 771 0.215580393086428 1027 672022
SGTC_535 2293-4129 48.2 µM 0.785938951493944 0.222842721496593 no 772 0.215951626669958 1115 396118 YIL048W NEO1
SGTC_2703 st077852 53.4 µM 0.785049026304231 0.223110710110739 no 773 0.216212412228166 1019 6281836
SGTC_1135 dihydrocapsaicin 536.708 nM 0.784888632624925 0.22315902994969 no 774 0.216259433717806 1000 107982 A Capsaicinoid.
SGTC_2010 4012422 159 µM 0.784014830923011 0.223422374100525 no 775 0.216515703995311 1041 952393
SGTC_1583 clindamycin 39.6 µM 0.78306607038802 0.223708509262014 no 776 0.216794157213125 966 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis.
SGTC_924 2046-0044 21.3 µM 0.781866688977468 0.224070526757062 no 777 0.217146461705753 1109 3623589
SGTC_2351 9026858 72.31 µM 0.781617796272875 0.224145693416628 no 778 0.217219612493562 1028 1409300
SGTC_2633 5,7-dihydroxyisoflavone 100 µM 0.777315415105669 0.225447292166868 no 779 0.218486351261725 1047 5377381
SGTC_2859 9028643 45.46 µM 0.776679159030223 0.225640141134567 no 780 0.218674042860671 1049 17151580
SGTC_2777 climbazole 1.536 µM 0.77641166397023 0.225721246644575 no 781 0.218752979948325 1074 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2
SGTC_2315 7733312 200 µM 0.776392934665248 0.225726926058138 no 782 0.218758507531108 1039 726316
SGTC_2985 9022375 71.43 µM 0.775198806150625 0.226089196549384 no 783 0.219111096769481 1127 4939335
SGTC_286 k060-0067 22.9 µM 0.772763208694684 0.226829117193222 no 784 0.219831265429762 1045 5985051
SGTC_583 1488-1091 88.9 µM 0.772706034051826 0.226846502919202 no 785 0.219848187396123 1205 4303273
SGTC_901 1112-0062 60.1 µM 0.770772836556944 0.227434793899125 no 786 0.220420795285051 1114 1908457
SGTC_44 0929-0055 61.211 µM 0.770622447174934 0.227480594863697 no 787 0.220465376021587 1042 1379590
SGTC_3335 9143315 29.6265 µM 0.769470108649377 0.227831710980701 no 788 0.2208071413975 1055 4899691
SGTC_1806 st050005 60.3 µM 0.768196559144105 0.228220114456038 no 789 0.221185208711288 1070 5194765
SGTC_655 k060-0012 42 µM 0.766645079124499 0.228693782934317 no 790 0.22164628276833 1079 5994525
SGTC_2725 haloperidol 53.21 µM 0.766118540004074 0.228854661251709 no 791 0.221802886177717 1087 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_1391 3442-0225 151 µM 0.765798329087293 0.228952529276941 no 792 0.221898154294362 1043 5227075
SGTC_2030 5175110 200 µM 0.765635052876225 0.229002441425241 no 793 0.221946740699107 1114 2831986
SGTC_2199 6590217 200 µM 0.765552862686517 0.229027568576655 no 794 0.22197120048461 1041 703109
SGTC_3303 9125618 40.5795 µM 0.765392252534624 0.229076674711362 no 795 0.222019002478888 1117 22695467
SGTC_1684 st024538 14.6195 µM 0.76424406549205 0.229427901888769 no 796 0.222360905635272 1093 6732859
SGTC_1688 st021091 57.6 µM 0.76391954143564 0.229527227562117 no 797 0.222457595697778 1124 3656366
SGTC_843 0310-0051 143 µM 0.762900911915876 0.229839151543313 no 798 0.222761246163599 1083 2065037
SGTC_463 ikarugamyin 104 µM 0.762445936913132 0.229978550292439 no 799 0.222896949148843 1113 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis.
SGTC_1458 k015-0034 6.33 µM 0.760072457625474 0.230706521954477 no 800 0.223605637449028 1093 3598957
SGTC_2942 9052777 62.25 µM 0.759795299257832 0.230791613266963 no 801 0.223688476599613 1151 6469503
SGTC_3159 9100096 49.47 µM 0.75959542528528 0.230852988117002 no 802 0.223748227243975 1093 25236875
SGTC_1384 3089-0840 101 µM 0.75815612265445 0.231295220560014 no 803 0.224178762493588 1071 1069836
SGTC_2712 st079126 47.7 µM 0.75768298117258 0.231440698621785 no 804 0.224320394883725 1083 3152970
SGTC_1366 1683-0113 21.9 µM 0.754807277246972 0.232325995459411 no 805 0.225182313400862 1122 708623
SGTC_746 1095-0025 46.6 µM 0.753978215277105 0.232581574892059 no 806 0.225431151418087 1125 6749286
SGTC_719 2810-4230 27.3 µM 0.751275874504971 0.233415724310107 no 807 0.226243322678347 1094 721079
SGTC_1168 k815-0004 80.5 µM 0.75120744276484 0.233436869112657 no 808 0.22626391083943 1112 642433
SGTC_2296 7971656 126.45 µM 0.750976909627033 0.233508109632408 no 809 0.226333276112501 1117 666570
SGTC_556 4058-0063 51.5 µM 0.75030528450398 0.233715727358488 no 810 0.226535430310486 1152 6615692
SGTC_1073 triclabendazole 3.09 µM 0.746234136720675 0.23497641829038 no 811 0.227762995090575 1144 50248 An antihelmetic and likely tubulin inhibitor.
SGTC_2752 diclazuril 33.15 µM 0.745557811161312 0.235186215817406 no 812 0.227967288167241 1207 456389 An antifungal agent for coccidioides. YHR062C RPP1
SGTC_452 diindolylmethane 8 µM 0.7445356150958 0.235503499283605 no 813 0.228276251542234 1048 3071 Inhibits expression of several cancer promoting factors.
SGTC_1466 k213-0079 57.5 µM 0.74352450355255 0.235817574393376 no 814 0.228582095988067 1098 3657981
SGTC_1401 3807-4679 7.6 µM 0.743345528324588 0.235873192369152 no 815 0.228636256986305 1088 3291456
SGTC_618 k072-0232 33.2 µM 0.74330661646374 0.235885285496328 no 816 0.228648033341829 1096 5872756 YGL099W LSG1
SGTC_40 0327-0103 19.753 µM 0.742860278789771 0.236024023895451 no 817 0.228783138137305 1064 409036
SGTC_1983 st071813 46.9 µM 0.742057444692599 0.236273687818255 no 818 0.229026265872115 1082 11838595
SGTC_574 1315-0397 40 µM 0.741945205061442 0.236308603482651 no 819 0.229060267711853 1187 6794277
SGTC_1205 4161-2785 76 µM 0.739560249832036 0.237051189918433 no 820 0.229783434359044 1036 3498106
SGTC_2729 fluphenazine 10.66 µM 0.739417202030903 0.237095770416248 no 821 0.229826849946151 1102 3372 An atypical antipsychotic.
SGTC_2877 9040724 71.43 µM 0.739370993254665 0.237110172252855 no 822 0.22984087547829 1122 6463895
SGTC_1070 indatraline 8.81 µM 0.739049311411073 0.237210443785358 no 823 0.22993852733137 1120 10314472 A monamine transport inhibitor. YGL099W LSG1
SGTC_550 4123-0385 25.7 µM 0.738900172554653 0.237256939799466 no 824 0.229983808779995 1132 5731123
SGTC_1201 1889-3372 45.9 µM 0.738672299640618 0.237327991865192 no 825 0.230053005052349 1075 5392199
SGTC_1985 st071382 65.5 µM 0.738590883460568 0.237353380724373 no 826 0.230077730850992 1188 6123237
SGTC_1846 st056244 14.8 µM 0.738429405946124 0.237403740359111 no 827 0.230126775385503 1126 5393182
SGTC_1626 st003712 1.76 µM 0.736747731202298 0.237928549054056 no 828 0.230637887215675 1088 24207035
SGTC_2990 9074105 71.4286 µM 0.736571000802767 0.237983739110917 no 829 0.230691637736693 1110 6502001
SGTC_2198 6589944 200 µM 0.735891468433621 0.238196011478616 no 830 0.230898374872661 1062 5290268
SGTC_1627 st003713 25.6 µM 0.735068852421838 0.23845311906497 no 831 0.231148781333537 1179 16195070 YER133W GLC7
SGTC_363 0455-0021 3.06 µM 0.735015200884857 0.238469893061104 no 832 0.231165118263601 1139 4597466
SGTC_2514 salinomycin 42.74 µM 0.73400834051471 0.238784804803844 no 833 0.231471827412428 1172 23682228 A polyether potassium ionophore.
SGTC_3310 9130229 44.1445 µM 0.73388819202544 0.238822398359418 no 834 0.231508442113417 1108 7761258
SGTC_1757 st041620 31.8375 µM 0.729699510599778 0.240135026871751 no 835 0.232786940170027 1171 5289815
SGTC_1860 st056228 74.6 µM 0.727851196898224 0.240715490466428 no 836 0.233352340275415 1139 688679
SGTC_3311 9131146 2.8755 µM 0.727842765644984 0.240718140053084 no 837 0.233354921144709 1099 4900406 YPR165W RHO1
SGTC_392 N-ethylmaleimide 8.33 µM 0.726266965671549 0.241213626002633 no 838 0.233837563237926 1110 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides.
SGTC_966 1300-0360 30.2 µM 0.725997738614049 0.241298335700012 no 839 0.233920078434102 1151 70588
SGTC_3320 9137005 35.139 µM 0.725584894036336 0.241428264658928 no 840 0.234046642185265 1102 4908713
SGTC_46 0329-0187a 2.197 µM 0.724624851147346 0.241730552785477 no 841 0.234341104452473 1170 46494817
SGTC_2184 6075246 200 µM 0.722865282241558 0.24228512007364 no 842 0.234881327477022 1146 2267320
SGTC_1438 4092-1045 4 µM 0.721293971194377 0.242780935926323 no 843 0.235364332733065 1161 1351342
SGTC_1354 1498-1681 81 µM 0.721184610308 0.242815464392882 no 844 0.235397969566738 1184 5754243
SGTC_96 0929-0093 37.281 µM 0.720919053513556 0.242899319588276 no 845 0.235479659626431 1106 6991579
SGTC_3252 9135871 49.47 µM 0.719782610268124 0.243258352605904 no 846 0.235829426719438 1201 17682838
SGTC_2543 pimpinellin 60.67 µM 0.719514078924842 0.243343230766855 no 847 0.235912115360155 1100 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo.
SGTC_2618 avocadyne 43.43 µM 0.717045733641673 0.244124181633901 no 848 0.236672939021455 1125 3015189
SGTC_923 1900-2434 73.3 µM 0.716808665679753 0.24419925778491 no 849 0.236746081991534 1163 5910570
SGTC_752 1896-0090 130 µM 0.716738439598725 0.244221499805081 no 850 0.236767751346968 1153 772567
SGTC_1076 itraconazole 331 nM 0.715826754663526 0.244510347963729 no 851 0.237049164964348 1188 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1
SGTC_2145 5634607 200 µM 0.715097706459755 0.244741463886163 no 852 0.237274335535109 1139 308662
SGTC_519 k048-0011 62.8 µM 0.714945812421077 0.244789630688637 no 853 0.237321263631765 1133 6836379
SGTC_1779 st039427 55 µM 0.714537196089115 0.244919231487245 no 854 0.23744753210834 1216 1124498
SGTC_2196 6573537 42.6665 µM 0.714512403940871 0.244927095998171 no 855 0.237455194434561 1195 2903087
SGTC_1280 0880-0253 10.1 µM 0.714499117603798 0.24493131071682 no 856 0.237459300800531 1148 6836607
SGTC_2024 5144227 134 µM 0.71177455331209 0.245796426482793 no 857 0.238302196346751 1172 3475211
SGTC_1266 0828-0227 32.9 µM 0.711123269682526 0.24600346761044 no 858 0.238503925689476 1131 3913820
SGTC_3050 9093513 49.47 µM 0.710396977909946 0.246234463910392 no 859 0.238728998354072 1198 25236664
SGTC_2140 5586273 200 µM 0.708673224453826 0.246783167041621 no 860 0.239263642196178 1171 854421
SGTC_1187 1391-0724 117 µM 0.708049263412525 0.246981946815013 no 861 0.239457332704134 1206 6997986
SGTC_43 0570-0105 72.5 µM 0.705946767104813 0.247652384485542 no 862 0.240110621253022 1216 1114046 YDL195W SEC31
SGTC_71 0417-1750 47.813 µM 0.704257490239202 0.248191759406189 no 863 0.240636217184938 1166 6811472
SGTC_510 ag-490 170 µM 0.703632271191162 0.248391546436587 no 864 0.240830904415734 1282 5328779
SGTC_1150 3909-7983 10.9 µM 0.702127776343725 0.24887265473679 no 865 0.241299740743612 1189 23965914
SGTC_2428 5615643 7.78 µM 0.701876615859624 0.248953019280568 no 866 0.241378056595838 1187 2253075
SGTC_2288 7946289 167.31 µM 0.700300405111804 0.249457679111166 no 867 0.241869859408609 1215 1246052
SGTC_3288 9119690 36.221 µM 0.699249442125561 0.249794470741547 no 868 0.242198078426838 1174 17595618 YKL019W RAM2
SGTC_837 0091-0265 12.5 µM 0.698701010435554 0.249970316990778 no 869 0.242369451176929 1159 759367
SGTC_561 1550-0330 72.9 µM 0.698609454895635 0.249999679274407 no 870 0.242398066652671 1162 6812934
SGTC_978 1416-0512 87.4 µM 0.698253913399947 0.250113720421687 no 871 0.242509207692372 1215 6814003
SGTC_850 0388-0143 75.9 µM 0.697232728929586 0.250441422217352 no 872 0.242828579846891 1156 67273
SGTC_2930 9013230 14.89 µM 0.695811715641865 0.250897808888012 no 873 0.243273375646438 1176 2995857
SGTC_2115 tiliquinol 12.7705 µM 0.694846023980978 0.251208211013303 no 874 0.243575900949288 1165 71208 A bioactive hydroxyquinoline.
SGTC_617 3770-0098 35 µM 0.69466977480603 0.251264884666152 no 875 0.24363113700688 1152 5962639
SGTC_2421 5690543 90.72 µM 0.693378210949154 0.251680398587784 no 876 0.244036116258286 1205 3397993
SGTC_698 k064-0052 127 µM 0.693256638396893 0.251719528834893 no 877 0.244074254906749 1238 5088751
SGTC_3007 9078383 71.4286 µM 0.692610058586772 0.251927695798033 no 878 0.244277148117484 1196 6496995
SGTC_2558 carylophyllene oxide 100 µM 0.691905224657268 0.252154721190004 no 879 0.244498424683463 1286 6708694 An oxygenated terpenoid and antifungal agent.
SGTC_1029 k015-0030 64.7 µM 0.691658046170365 0.252234362362086 no 880 0.244576049815765 1184 2208316
SGTC_3199 9111318 49.47 µM 0.689173913893959 0.253035488365072 no 881 0.245356915309988 1156 8548020
SGTC_763 3453-1109 128 µM 0.688552585204243 0.253236074291911 no 882 0.245552433887973 1221 1560353
SGTC_3022 9087993 49.47 µM 0.687829529433521 0.253469606385888 no 883 0.245780069087783 1217 17173644
SGTC_1575 cyproterone acetate 48 µM 0.687739289689029 0.253498759902476 no 884 0.245808486660912 1169 9880 An androgen receptor antagonist and liver toxin.
SGTC_914 3820-6779 408 µM 0.685959328883598 0.254074167081522 no 885 0.246369377909446 1194 2893481
SGTC_1720 st037298 9.481 µM 0.682140522282782 0.255310979065921 no 886 0.247575049753842 1210 597396
SGTC_3296 9122258 64.045 µM 0.681892368366053 0.255391458416716 no 887 0.247653505712817 1216 4730474
SGTC_1121 fusaric acid 630.51 nM 0.68133196711422 0.255573252163124 no 888 0.247830730149726 1208 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler.
SGTC_1313 1220-0047 237 µM 0.681070914101915 0.255657960636447 no 889 0.247913310128457 1235 3528706
SGTC_1731 st035964 63 µM 0.680817714550172 0.255740134763535 no 890 0.247993419817265 1193 6739575
SGTC_1839 st053978 48 µM 0.680391335019755 0.255878544386592 no 891 0.248128353048043 1264 3788398
SGTC_1635 st007035 42.4 µM 0.679049181439309 0.256314484006737 no 892 0.24855335015602 1238 3716403
SGTC_2806 7952793 58.44 µM 0.678995062097124 0.256332070413269 no 893 0.248570495344759 1223 2972490
SGTC_727 3032-0951 202 µM 0.678722727725282 0.256420576653418 no 894 0.248656781346913 1196 3652836
SGTC_3237 9133362 49.47 µM 0.677844233808396 0.256706187829588 no 895 0.248935230701585 1177 43845137
SGTC_3244 9134489 49.47 µM 0.677376800596794 0.256858224661864 no 896 0.249083456967641 1191 16584271
SGTC_2738 aclarubicin 5.55 µM 0.677162946422948 0.256927798264998 no 897 0.249151287239106 1132 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31
SGTC_1568 digitonin 820 nM 0.676433668924868 0.257165129273252 no 898 0.249382673351074 1240 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1
SGTC_3337 9144342 33.5465 µM 0.676114588545254 0.257269004413516 no 899 0.249483947497487 1224 17682949
SGTC_739 1486-1183 203 µM 0.675484542959389 0.257474176867337 no 900 0.249683984248865 1221 4346692
SGTC_2842 9000675 19.48 µM 0.675012561054719 0.257627932028289 no 901 0.249833892253803 1192 2989072
SGTC_944 3370-0224 231 µM 0.674213899063376 0.257888216665438 no 902 0.250087667181781 1236 4580514
SGTC_1665 st014639 11.4 µM 0.673772466724247 0.258032138375662 no 903 0.250227991010393 1295 981133 YIL048W NEO1
SGTC_2245 6637752 200 µM 0.673087140648238 0.258255660115281 no 904 0.250445927209264 1203 681890
SGTC_1425 4048-4433 7.33 µM 0.673001080019396 0.258283736211891 no 905 0.250473301911581 1280 23734946
SGTC_887 0885-0007 9.62 µM 0.672177371589823 0.25855253976588 no 906 0.250735392430897 1253 5719458
SGTC_2256 7954252 200 µM 0.670784044856877 0.259007558354254 no 907 0.251179056533892 1187 2972920
SGTC_2486 5283202 22.39 µM 0.670782207772047 0.259008158564151 no 908 0.251179641773722 1208 1377751
SGTC_2139 5578692 56.4705 µM 0.670737347317247 0.259022815535147 no 909 0.251193933185679 1191 650991 YMR113W FOL3
SGTC_1835 st008666 49.2 µM 0.668769469335572 0.259666189641582 no 910 0.25182127254575 1182 690455
SGTC_1221 2958-7315 257 µM 0.66829082713704 0.259822800593601 no 911 0.251973983740918 1246 4562705
SGTC_2255 7941087 197.44 µM 0.667985287292156 0.259922798213977 no 912 0.25207149203366 1263 935561
SGTC_2564 betulinic acid 100 µM 0.666373822279556 0.260450529582838 no 913 0.252586095233294 1277 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14
SGTC_507 nimesulide 162 µM 0.664009972914259 0.261225653091171 no 914 0.253341964068641 1291 4495 A COX2 inhibitor.
SGTC_218 alverine citrate 93.75 µM 0.663760870443585 0.261307404596142 no 915 0.253421686730064 1256 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_1317 1273-0028 910 nM 0.663484375966219 0.261398161113703 no 916 0.253510191355848 1225 5917803 YLR359W | YHR072W ADE13 | ERG7
SGTC_3295 9122362 53.5725 µM 0.662280361438697 0.261793555356973 no 917 0.253895780190836 1241 4730473
SGTC_2383 9036125 200 µM 0.661358369981173 0.262096541474892 no 918 0.254191258363644 1195 79580
SGTC_3259 9138485 49.47 µM 0.661276468764871 0.262123464655394 no 919 0.254217514636957 1363 17646153
SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM 0.661214602335472 0.262143802790476 no 920 0.254237349007804 1273 4213774
SGTC_871 0574-0004 149 µM 0.660742700087657 0.262298963798816 no 921 0.254388667515066 1234 9551173
SGTC_2696 st077691 74.316 µM 0.659881534029431 0.262582235573712 no 922 0.254664927599231 1248 757133
SGTC_1504 k297-0033 30 µM 0.659485882974956 0.262712433413985 no 923 0.25479190419862 1153 4388117
SGTC_927 2425-1185 123 µM 0.659268189444769 0.262784084427487 no 924 0.254861782884283 1235 730375
SGTC_2811 7967822 32.47 µM 0.657013217181059 0.263526866947114 no 925 0.255586208948636 1275 2232244
SGTC_137 0438-0332 85.389 µM 0.656899518228238 0.263564347467435 no 926 0.25562276401615 1277 2063393 YER012W | YPR107C PRE1 | YTH1
SGTC_3242 9133940 49.47 µM 0.656569331943521 0.263673207808064 no 927 0.255728936863984 1293 17248444
SGTC_786 4544-0069 423 µM 0.656300450531294 0.263761873258529 no 928 0.255815413867001 1282 748821 YLR208W SEC13
SGTC_872 0588-0139 234 µM 0.655408119140887 0.264056234447736 no 929 0.256102512723423 1270 2047100
SGTC_1544 7-methoxy-4-methylcoumarin 105 µM 0.654487267563107 0.264360179239991 no 930 0.256398963762745 1220 390807
SGTC_1546 5-methoxyflavanone 78.7 µM 0.654097024510393 0.264489040182954 no 931 0.256524649182201 1297 147795
SGTC_1521 st012942 49.4 µM 0.65152988635537 0.265337522853157 no 932 0.257352245589284 1309 24207259
SGTC_643 k048-0106 28.4 µM 0.65151979327393 0.26534086151224 no 933 0.257355502142504 1287 6763920
SGTC_2496 diffractaic acid 79.83 µM 0.650042802116801 0.265829660588582 no 934 0.257832287097505 1346 94870 An apoptosis inducer which activates caspases.
SGTC_1349 flufenamic acid 69 µM 0.649424281396804 0.266034490840058 no 935 0.258032086786896 1239 3371 A non-steroidal anti-inflammatory.
SGTC_766 1391-0721 126 µM 0.646734289946543 0.266926241324489 no 936 0.258901963250681 1291 1020919 YIL115C NUP159
SGTC_659 k018-0002 107 µM 0.64647922012105 0.267010877018301 no 937 0.25898452517838 1256 6797879 YHR007C ERG11
SGTC_2984 9022109 38.96 µM 0.646080475266864 0.267143213220158 no 938 0.259113619639266 1318 6459207
SGTC_902 1120-0002 2.07 µM 0.644055223967504 0.267815868226007 no 939 0.259769812126781 1260 3280475
SGTC_1609 st001574 46.4 µM 0.643917983957681 0.267861481162605 no 940 0.25981430964347 1259 3960012
SGTC_221 trifluoperazine 10.304 µM 0.643595397572528 0.267968711020238 no 941 0.259918917753995 1286 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1
SGTC_3183 9108214 49.47 µM 0.643498067294647 0.26800106849542 no 942 0.259950484221101 1207 4974831
SGTC_2322 7413319 38.22 µM 0.64028804269331 0.269069343111356 no 943 0.260992676513972 1306 1840400
SGTC_1472 k841-0093 193 µM 0.638784263692965 0.269570524666404 no 944 0.261481643374816 1337 X1472
SGTC_1404 3909-7820 48.3 µM 0.637507665507673 0.269996357875856 no 945 0.261897109233539 1267 23741373
SGTC_3206 9114350 49.47 µM 0.636526800131948 0.270323772398676 no 946 0.262216559366731 1236 17087243
SGTC_3287 9117173 37.0625 µM 0.635217112723019 0.270761257501389 no 947 0.262643411909426 1267 2789709
SGTC_2796 7949634 45.45 µM 0.634524893362575 0.270992627630984 no 948 0.26286916316631 1271 2971588
SGTC_694 1315-0438 43.2 µM 0.631302971333696 0.272070831813611 no 949 0.263921222243228 1276 6793154
SGTC_3207 9114163 49.47 µM 0.631054234309733 0.272154159335984 no 950 0.264002531873301 1366 849233
SGTC_964 1287-0107 19.4 µM 0.630927606277538 0.272196584914503 no 951 0.264043930205882 1338 51516812 YPR165W RHO1
SGTC_2589 lobaric acid 100 µM 0.630728742420185 0.272263219087754 no 952 0.264108951175652 1275 73157 A novel microtubule depolymerizer.
SGTC_1102 cgs 12066b 26.1 µM 0.630519923003008 0.272333197836942 no 953 0.264177236016131 1274 6438352 A 5-HT1B full agonist.
SGTC_1045 1348-1485 165 µM 0.630386100316176 0.272378048671819 no 954 0.264221001333268 1305 6810614
SGTC_666 0272-0154 136 µM 0.629447877657002 0.272692598126718 no 955 0.264527940948602 1311 6870312
SGTC_1984 st072354 53.1 µM 0.629258770366468 0.272756020244952 no 956 0.264589829375112 1234 5762938
SGTC_2758 dehydroepiandrosterone 69.35 µM 0.628681456229974 0.272949683031962 no 957 0.264778810342004 1338 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem]
SGTC_513 4245-1575 41.7 µM 0.625504312633386 0.274016689574348 no 958 0.265820059412494 1277 719745
SGTC_2036 5160441 105 µM 0.624335118781543 0.274409867869643 no 959 0.266203762437628 1335 134534 YIL048W NEO1
SGTC_2636 apigenin dimethyl ether 100 µM 0.622822412595741 0.274918975853906 no 960 0.266700614177672 1313 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_1880 MG-132 525 µM 0.622566128952171 0.27500527533805 no 961 0.266784837527906 1264 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1
SGTC_2767 sibutramine 71.45 µM 0.621100308940859 0.275499123463727 no 962 0.26726681300499 1384 64765 A serotonin-norepinephrine reuptake inhibitor.
SGTC_3301 9125354 19.7965 µM 0.620818194896821 0.275594220289134 no 963 0.267359625165312 1306 41905162
SGTC_1873 rapamycin 2 nM 0.618826243169618 0.276266139226538 no 964 0.268015415927442 1316 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1
SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM 0.618145944728096 0.276495799371307 no 965 0.268239569300154 1356 6708739 YPR165W RHO1
SGTC_1153 4055-0057 267 µM 0.616741897126088 0.276970083834015 no 966 0.268702490760124 1291 882706
SGTC_1042 0350-0096 82 µM 0.615283798825155 0.277463047725403 no 967 0.269183657484056 1309 3122515
SGTC_3325 9138760 55.175 µM 0.614079981147671 0.27787036561712 no 968 0.269581238091688 1284 43844959
SGTC_2682 pyrogallin 40.03 µM 0.612496210312424 0.278406686835017 no 969 0.270104752286211 1319 822798 An ATP competetive kinase inhibitor.
SGTC_1814 st052110 31.539 µM 0.60958773746712 0.279392911187689 no 970 0.271067468353039 1320 674163
SGTC_2081 5214970 32.255 µM 0.608845645683665 0.279644816081566 no 971 0.271313377438571 1309 2063512
SGTC_34 0469-0683 81.75 µM 0.607921702953666 0.279958604713913 no 972 0.271619702302614 1347 3690923
SGTC_515 4092-1064 102 µM 0.60690285244751 0.280304823649861 no 973 0.271957692508363 1402 717353
SGTC_1987 st072290 61.9 µM 0.606245870822041 0.280528184648164 no 974 0.272175748370457 1364 54697379
SGTC_1226 3909-7979 35.4 µM 0.605005993122267 0.28094995352764 no 975 0.272587507304277 1367 6615510
SGTC_2533 agelasine 13.65 µM 0.603707310385264 0.28139205445795 no 976 0.273019126492799 1389 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase.
SGTC_2415 st077333 57.7 µM 0.601229322773748 0.282236547695931 no 977 0.273843628297102 1444 2766255
SGTC_1796 st049173 110.4 µM 0.600491465974584 0.282488243283545 no 978 0.274089373346078 1297 94134
SGTC_908 3448-7491 47.7 µM 0.596849447446492 0.283732176835335 no 979 0.27530395053426 1343 1203031
SGTC_2243 6634756 200 µM 0.595150159733675 0.284313465658532 no 980 0.275871551107976 1416 885676
SGTC_1281 0884-0031 11.8 µM 0.594563248275406 0.284514367279926 no 981 0.276067726316138 1343 1548255
SGTC_711 k292-0785 179 µM 0.591931820289166 0.285415945810985 no 982 0.27694812239843 1337 4146315
SGTC_360 0957-0399 1.01 µM 0.591804170957958 0.285459715536678 no 983 0.276990864931224 1393 6752301 YPR165W RHO1
SGTC_395 anisomycin 6.25 µM 0.591715704922892 0.285490051562496 no 984 0.277020489091332 1301 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_1851 st056236 18.9 µM 0.591519143733299 0.285557460159035 no 985 0.277086316062968 1387 5393171
SGTC_293 4049-0273 38.5 µM 0.591272505532007 0.285642052856013 no 986 0.277168924303937 1291 1380311
SGTC_2956 9076196 2.52 µM 0.590369227384056 0.285951963618025 no 987 0.277471568343824 1384 16423868
SGTC_3198 9112019 49.47 µM 0.589829075860694 0.286137363563869 no 988 0.277652623669905 1389 45595555
SGTC_1859 st055998 20 µM 0.589496216171252 0.2862516417282 no 989 0.277764224835455 1405 676301
SGTC_164 4100-3994 89.624 µM 0.588283264020865 0.286668258568629 no 990 0.278171088569905 1423 4615967
SGTC_453 enantio-paf c16 10 µM 0.587058234321391 0.287089315337871 no 991 0.278582298284274 1334 13871343 A lipid and platelet activating factor
SGTC_1031 k035-0009 16 µM 0.585447562695045 0.287643366885468 no 992 0.2791234078028 1397 5180959
SGTC_2737 bleomycin 30.5 nM 0.585232761267915 0.287717294151792 no 993 0.279195609526496 1371 16211318 Bleomycin acts by induction of DNA strand breaks.
SGTC_2038 4100038 30.985 µM 0.585023262963263 0.287789404912457 no 994 0.2792660374424 1378 3596803
SGTC_1433 4060-0023 7.6 µM 0.584199173976507 0.288073144835671 no 995 0.279543158606896 1386 3840627
SGTC_2708 st078559 56 µM 0.583674030738029 0.288254024373692 no 996 0.279719821179207 1298 17250902
SGTC_1878 temozolomide 1 mM 0.583667002027652 0.288256445695229 no 997 0.279722186063449 1374 5394 DNA alkylating agent.
SGTC_141 0443-0274 32.331 µM 0.58338158398877 0.288354777502889 no 998 0.279818226188454 1423 1627241
SGTC_2471 5466956 24.79 µM 0.582666026075961 0.288601369975722 no 999 0.280059074087547 1377 724419
SGTC_2004 4023728 41.89 µM 0.582530196728043 0.288648190114153 no 1000 0.280104803902433 1351 360084 YDR527W RBA50
SGTC_1007 4101-0031 70 µM 0.58107870772714 0.28914873907648 no 1001 0.280593704114868 1368 1146276
SGTC_3312 9133330 71.43 µM 0.579970618252634 0.289531140517053 no 1002 0.280967215918904 1424 17617324
SGTC_1868 st057644 42.7 µM 0.578375127673097 0.290082160740662 no 1003 0.28150544126384 1354 688665
SGTC_2484 5809818 12.04 µM 0.577746869220434 0.290299271503817 no 1004 0.281717515381996 1375 2870548
SGTC_829 1635-0120 117 µM 0.576888478643682 0.290596033267363 no 1005 0.282007397053837 1427 285054
SGTC_615 k087-0205 167 µM 0.576111497933771 0.290864772428324 no 1006 0.282269910119682 1320 9642773
SGTC_462 ag-879 158 µM 0.574369263751346 0.291467791730645 no 1007 0.282858973754027 1402 6809654 Ag-879 is a 5-Lipoxygenase inhibitor.
SGTC_2333 9017922 200 µM 0.572536442917893 0.292102793434641 no 1008 0.283479302010242 1489 3163164
SGTC_2152 5568786 200 µM 0.570845076956926 0.292689357109744 no 1009 0.284052331950113 1361 5399883
SGTC_2372 9071633 200 µM 0.569850536380768 0.29303451780621 no 1010 0.284389537952528 1410 21321366
SGTC_215 1287-0124 461.5 µM 0.56976673948769 0.293063608595287 no 1011 0.28441795861567 1452 5560863
SGTC_547 1120-0019 610 nM 0.569729373685562 0.293076580876418 no 1012 0.284430632087129 1397 3676939
SGTC_1261 0712-0010 12.7 µM 0.569629982042849 0.293111087957725 no 1013 0.284464344362711 1430 2840123
SGTC_592 k241-0073 46.5 µM 0.568550500817457 0.293485986715225 no 1014 0.284830612411972 1447 4230158
SGTC_795 0685-0265 78 µM 0.565674655326346 0.294485836733292 no 1015 0.285807483687746 1403 302754
SGTC_826 1683-5028 118 µM 0.565468791054836 0.294557470167634 no 1016 0.285877473021397 1399 722377
SGTC_2622 2-methoxyxanthone 59.94 µM 0.563923725340884 0.295095354439872 no 1017 0.286403021368805 1472 71034 A hepatoprotective.
SGTC_900 1112-0045 141 µM 0.563316747160398 0.295306785656757 no 1018 0.286609608117536 1321 56211 YIL048W NEO1
SGTC_3273 9137859 49.47 µM 0.561612149558378 0.295900927651543 no 1019 0.287190150383175 1442 2377234
SGTC_1707 st032323 6.317 µM 0.561429807981104 0.295964515777755 no 1020 0.287252284193307 1363 3132057 YMR211W DML1
SGTC_2126 5251174 33.877 µM 0.560755587970895 0.296199691537231 no 1021 0.287482083288547 1505 790722
SGTC_1833 st055984 71 µM 0.560526217894332 0.296279718018259 no 1022 0.287560280900412 1390 676288
SGTC_2045 5106652 78.05 µM 0.560220051061179 0.29638655408874 no 1023 0.287664675985742 1411 673349
SGTC_1267 0828-0272 9.49 µM 0.558082215184023 0.297133037699764 no 1024 0.288394122221445 1485 745334
SGTC_2382 9035899 200 µM 0.556967306563983 0.297522679130815 no 1025 0.288774883352928 1409 6462679
SGTC_537 1334-0398 209 µM 0.555499317613087 0.298036071561198 no 1026 0.289276588373497 1440 5846986
SGTC_211 3455-0679 143.504 µM 0.554995587635241 0.298212331512581 no 1027 0.289448839243194 1405 748649
SGTC_497 capsazepine 133 µM 0.55498068586007 0.298217546509568 no 1028 0.289453935650775 1341 2733484 A calcium channel blocker.
SGTC_2890 9046729 58.44 µM 0.55462548553971 0.298341864031791 no 1029 0.289575426645706 1341 903329
SGTC_3171 9103192 49.47 µM 0.554315676867468 0.29845031406552 no 1030 0.289681411645417 1437 13018434
SGTC_272 doxorubicin 8.13 µM 0.55413133843038 0.298514851143675 no 1031 0.289744482137178 1396 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_1320 1313-0481 95.3 µM 0.553303941320075 0.298804601898059 no 1032 0.290027651336425 1416 6813365 YLR208W SEC13
SGTC_1133 3473-0247 50 µM 0.552317612778117 0.299150176619644 no 1033 0.290365382791133 1356 711311
SGTC_811 0416-0114 265 µM 0.551455779756158 0.299452280916918 no 1034 0.290660636059365 1414 6612453
SGTC_7 0192-1582 4.227 µM 0.551337465578339 0.299493765200512 no 1035 0.290701179984546 1434 252616
SGTC_508 roscovitine 141 µM 0.551253701541116 0.299523136806548 no 1036 0.290729885860006 1468 160355 A CDKinase inhibitor.
SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM 0.551052916649765 0.299593546735848 no 1037 0.290798700094708 1370 6708760
SGTC_2788 5282734 71.43 µM 0.551019166850519 0.299605382630442 no 1038 0.290810267781343 1530 743706
SGTC_604 1000-0114 314 µM 0.550316738680177 0.299851768938477 no 1039 0.291051072667054 1487 1572745
SGTC_3254 9136651 49.47 µM 0.55003200507032 0.299951669275626 no 1040 0.291148710942756 1378 16454030
SGTC_210 3551-0445 56.827 µM 0.549093855046083 0.300280930839198 no 1041 0.291470521039827 1454 2865180 YOR207C RET1
SGTC_1330 1469-0054 61.8 µM 0.545512821772012 0.301539261691468 no 1042 0.292700432278644 1494 7102664
SGTC_567 1080-0542 68.4 µM 0.54382966796859 0.302131519592245 no 1043 0.293279345493157 1401 5950415
SGTC_442 cape 100 µM 0.54358418595959 0.302217941924266 no 1044 0.293363822257238 1489 5281787
SGTC_2238 6671620 73.2395 µM 0.543378495990682 0.302290363946483 no 1045 0.293434614222651 1364 729941
SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM 0.541620863079627 0.302909531666549 no 1046 0.294039858215505 1470 5024745
SGTC_2131 toluylene red 5.2905 µM 0.541166929879885 0.303069532554754 no 1047 0.294196264629151 1384 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain.
SGTC_2817 7995342 71.43 µM 0.540090185140986 0.303449211135537 no 1048 0.294567419512876 1348 18879975
SGTC_178 4092-0806 87.505 µM 0.537354462478735 0.304414828022266 no 1049 0.295511396022384 1424 2169044
SGTC_797 k781-0471 270 µM 0.536717372776775 0.304639895177911 no 1050 0.295731426953272 1487 23738129
SGTC_1347 1493-0251 600 nM 0.53608861571535 0.304862091160165 no 1051 0.29594865382977 1470 3986378
SGTC_297 0986-0032 24 µM 0.534275917118425 0.30550308204652 no 1052 0.296575325838318 1393 2847425
SGTC_1930 st074634 34.3 µM 0.534061210194432 0.305579044419911 no 1053 0.296649592889154 1392 684253 YOR116C RPO31
SGTC_959 1222-0044 107 µM 0.533979408621352 0.305607987661621 no 1054 0.296677890265604 1457 6083612
SGTC_3343 9148379 18.9835 µM 0.533764946879703 0.305683874829838 no 1055 0.296752084250158 1543 1955036
SGTC_350 k064-0020 19.8 µM 0.532181049765411 0.306244594223037 no 1056 0.29730030328223 1509 2790705
SGTC_1701 st028638 40.4 µM 0.531801284001774 0.306379103600652 no 1057 0.297431816690815 1508 3490878
SGTC_3108 9121785 49.47 µM 0.531561703378521 0.306463974176611 no 1058 0.297514797457267 1494 17140271
SGTC_3067 9117431 49.47 µM 0.530801097449031 0.306733484882003 no 1059 0.297778309745272 1443 17150885
SGTC_526 4469-0568 170 µM 0.530478729255872 0.306847743355926 no 1060 0.297890026473387 1423 2901964
SGTC_636 0kpi-0074 126 µM 0.528996242939954 0.307373429409169 no 1061 0.29840402808416 1426 616434
SGTC_974 1326-0144 138 µM 0.528664544771448 0.307491103022434 no 1062 0.298519088356131 1427 5411856
SGTC_2060 5238662 140 µM 0.527727544587039 0.307823621272783 no 1063 0.298844226252434 1424 790130
SGTC_1459 k035-0031 35.7 µM 0.52705935405449 0.30806084207189 no 1064 0.299076185776081 1342 3877128 YMR208W ERG12
SGTC_1973 st070275 50.2 µM 0.525946122585479 0.308456239280485 no 1065 0.299462820801379 1411 17118334
SGTC_3338 9144300 39.5675 µM 0.525916196328681 0.308466871548865 no 1066 0.299473217579098 1462 4901274
SGTC_1505 k297-0037 20.6 µM 0.524723112185545 0.308890883966818 no 1067 0.299887844033327 1417 4089396
SGTC_1357 1503-1303 39.5 µM 0.52445085210096 0.308987678720082 no 1068 0.299982497595901 1459 292895
SGTC_225 nsc-122657 1.016 µM 0.524403557541959 0.309004494381478 no 1069 0.29999894133458 1444 275685
SGTC_991 3996-0057 64.7 µM 0.521559670386501 0.310016377946931 no 1070 0.300988474666142 1467 715343
SGTC_3182 9108849 49.47 µM 0.519425427090368 0.310776709941834 no 1071 0.301732051808768 1453 17133045
SGTC_172 1112-0046 2.638 µM 0.518432999679877 0.311130541528268 no 1072 0.30207809775001 1468 2802135 YIL048W NEO1
SGTC_1436 4092-1007 8.32 µM 0.518432283898339 0.311130796789955 no 1073 0.302078347397597 1435 2881121
SGTC_1812 st052057 4.327 µM 0.518012166927136 0.311280634384505 no 1074 0.302224890192228 1415 3645418
SGTC_3162 9099653 49.47 µM 0.516271372048009 0.31190183385088 no 1075 0.30283244396394 1456 25237511
SGTC_2843 9000894 45.46 µM 0.512220713358663 0.313349374305961 no 1076 0.304248274025362 1359 2242070
SGTC_2836 9010338 19.48 µM 0.511890165079939 0.313467626196354 no 1077 0.304363940843806 1338 2994051
SGTC_1116 jasmonic acid 1.58368 µM 0.511238521500456 0.313700804379025 no 1078 0.304592023974382 1513 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid.
SGTC_235 0330-0087 5 mM 0.510648798931791 0.313911889487934 no 1079 0.304798499512899 1449 46494818 YHR062C RPP1
SGTC_2057 5236571 38.335 µM 0.510527980343414 0.313955142775228 no 1080 0.30484080857789 1545 54684039 YBR257W POP4
SGTC_1130 3454-2858 15.9 µM 0.50963682935732 0.314274255476222 no 1081 0.305152958403382 1442 715628 YIL048W NEO1
SGTC_1225 1216-0074 20.6 µM 0.50916659329332 0.314442698530105 no 1082 0.305317728515194 1432 4241466
SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM 0.50906768440372 0.314478133559388 no 1083 0.305352391086056 1437 16623 A steroid.
SGTC_603 3794-0023 45.9 µM 0.508581112371142 0.314652477394916 no 1084 0.305522935418764 1545 3802260
SGTC_930 2810-3379 265 µM 0.508562789073208 0.314659043631471 no 1085 0.305529358591001 1617 1015764
SGTC_2359 9039622 200 µM 0.508170323537707 0.314799699497901 no 1086 0.305666950470705 1481 6463596
SGTC_323 4013-0906 34.3 µM 0.50792256257534 0.314888508477606 no 1087 0.305753825469557 1540 2910086
SGTC_3332 9141069 11.198 µM 0.507873801934741 0.314905987805649 no 1088 0.305770924207004 1419 17332883
SGTC_2840 9008771 71.43 µM 0.50780781827535 0.31492964176512 no 1089 0.305794063159412 1557 2992978
SGTC_2260 7964312 200 µM 0.507698784014494 0.314968730257381 no 1090 0.305832300667142 1558 231951
SGTC_3068 9116768 49.47 µM 0.506485326404781 0.315403891379491 no 1091 0.306257994053715 1449 41904888
SGTC_3064 1327-0027 10 µM 0.506299395213539 0.315470591285051 no 1092 0.306323243758374 1404 16000455 YPR107C YTH1
SGTC_476 mead acid 10 µM 0.505592270978622 0.315724315945493 no 1093 0.306571454271656 1491 5312531 An omega 9 fatty acid.
SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM 0.505403274587301 0.315792144835183 no 1094 0.306637809687835 1399 5711223 A potent inhibitor of glutathione S-transferases.
SGTC_424 splitomicin 100 mM 0.504953485927773 0.315953594375332 no 1095 0.306795753079706 1430 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_2992 9074591 71.4286 µM 0.503034904926357 0.316642654077183 no 1096 0.307469865847299 1473 17741321
SGTC_1478 0453-0656 35.7 µM 0.501669168403376 0.317133547453645 no 1097 0.307950127835471 1502 5258496
SGTC_2925 9010536 32.5 µM 0.501518675286829 0.317187659641389 no 1098 0.308003068967552 1562 2994177
SGTC_1477 0139-0234 16 µM 0.499482677251113 0.317920118797123 no 1099 0.308719693677702 1520 620880
SGTC_2907 7721985 69.9 µM 0.498862327831847 0.318143434036617 no 1100 0.308938187504142 1431 3267881
SGTC_1108 betulinic acid 729.144 nM 0.498618772794988 0.318231127788727 no 1101 0.30902398873377 1473 64945 Apoptosis-inducing agent of unknown mechanism.
SGTC_1216 1165-0504 9.65 µM 0.498329289296787 0.318335371667269 no 1102 0.309125983507978 1539 6304004
SGTC_824 1304-0008 100 µM 0.49731502874479 0.318700723408596 no 1103 0.309483457671382 1493 768245
SGTC_673 1082-0474 110 µM 0.49376894031549 0.319979461103013 no 1104 0.310734685444059 1468 3098046
SGTC_2766 oltipraz 83.91 µM 0.492193610840814 0.320548221056663 no 1105 0.311291240355746 1568 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40
SGTC_1736 st036774 51 µM 0.492066004518376 0.320594310764208 no 1106 0.311336341856002 1669 1272247
SGTC_3181 9108277 49.47 µM 0.491593359672808 0.320765047894521 no 1107 0.311503419308626 1438 17097298
SGTC_1554 st069299 38.7 µM 0.49072631657581 0.321078355103632 no 1108 0.311810015374062 1487 24207999
SGTC_2462 5162487 171.77 µM 0.488787403776044 0.321779444702764 no 1109 0.312496108341203 1499 2259986
SGTC_2716 st080858 38.6235 µM 0.488748786593253 0.321793414710178 no 1110 0.312509779817889 1497 5296050
SGTC_2829 7992743 58.44 µM 0.488479652578252 0.321890782618466 no 1111 0.312605067351427 1586 16462845
SGTC_996 3970-0799 1.8 µM 0.487896750488412 0.322101708168411 no 1112 0.312811488156076 1570 6615648 YGL040C HEM2
SGTC_368 fentichlor 4.58 µM 0.485507194550086 0.32296697738608 no 1113 0.313658305235144 1451 7329 A pesticide.
SGTC_1654 st012436 41.8 µM 0.485464934858963 0.322982288458602 no 1114 0.313673290191832 1508 4323132
SGTC_1082 camptothecin 424.86 nM 0.485055709220598 0.323130570163726 no 1115 0.313818414309233 1365 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_2783 7738165 71.43 µM 0.484744252401681 0.323243444464809 no 1116 0.313928885876006 1411 17201110
SGTC_413 propylparaben 100 µM 0.483293052635489 0.323769584638078 no 1117 0.314443836123844 1456 7175 A pharmaceutical preservative.
SGTC_1570 verbenone 133 µM 0.483045121417912 0.323859508688947 no 1118 0.314531849309541 1597 29025 A natural terpanoid with antifungal properties.
SGTC_3051 9093778 49.47 µM 0.482994751697895 0.323877778920938 no 1119 0.314549731361722 1501 17217378
SGTC_2338 7999974 200 µM 0.479612154967902 0.325105692173168 no 1120 0.315751600873822 1600 315925
SGTC_3056 9094900 49.47 µM 0.479579407653466 0.325117589061033 no 1121 0.315763245867574 1431 25236784
SGTC_628 1636-0253 16 µM 0.478709993390346 0.325433506817372 no 1122 0.316072477725449 1577 4456143
SGTC_2711 st079103 59.1 µM 0.475934131716905 0.326443006414066 no 1123 0.317060652455232 1615 54693780
SGTC_759 3486-0358 89.3 µM 0.475154212778379 0.326726869403831 no 1124 0.317338529937872 1671 875103
SGTC_1105 epirubicin 18.1 µM 0.474741900135938 0.32687697721657 no 1125 0.317485474521796 1467 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_650 1328-0195 38 µM 0.474241207426232 0.327059298621393 no 1126 0.3176639556552 1538 2780821
SGTC_3069 9117009 49.47 µM 0.473902244812792 0.327182751336814 no 1127 0.317784809180645 1466 41904981
SGTC_2203 7227154 166.4 µM 0.471337086516201 0.328117613340751 no 1128 0.318700017809948 1519 896304
SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM 0.470744336668617 0.328333792228613 no 1129 0.318911659403432 1463 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1
SGTC_683 panaxydol 45 µM 0.470472472046583 0.328432961876761 no 1130 0.319008748546634 1578 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis.
SGTC_2593 nobiletin 86.24 µM 0.469191528616144 0.328900381666727 no 1131 0.319466370081631 1483 72344 An anti-infammatory.
SGTC_2047 4141938 200 µM 0.468589441899939 0.329120177307945 no 1132 0.319681562757408 1536 3807862
SGTC_1993 st073995 70.8 µM 0.467821829855288 0.329400484716332 no 1133 0.319956004125877 1550 3098394
SGTC_3078 9116413 49.47 µM 0.46684570113638 0.329757074261411 no 1134 0.320305138010927 1457 17177322
SGTC_1933 st074711 15.9 µM 0.465975104899691 0.330075242356189 no 1135 0.320616660152599 1490 17250958
SGTC_2458 5808907 16.39 µM 0.463671651461171 0.330917654897315 no 1136 0.321441505307625 1566 2731747
SGTC_1393 3470-5649 58.2 µM 0.46366451555009 0.330920265956207 no 1137 0.321444061982035 1493 4108395
SGTC_2906 7926292 26.41 µM 0.462670733769169 0.331283975032943 no 1138 0.321800199504909 1506 2966319
SGTC_1789 tunicamycin 25 nM 0.461935776962137 0.331553060523735 no 1139 0.322063688349266 1498 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_2084 5306078 60.6385 µM 0.46173372422674 0.331627052170024 no 1140 0.322136141816655 1565 679340
SGTC_3253 9135987 49.47 µM 0.460285854869512 0.3321574535351 no 1141 0.322655526459118 1549 4182430
SGTC_1962 st076595 64.5 µM 0.458843688795231 0.33268610007023 no 1142 0.323173209409153 1542 279619
SGTC_686 1319-0111 510 µM 0.45715696084074 0.333304816545034 no 1143 0.323779115515448 1638 4562600
SGTC_55 0767-0285 6.563 µM 0.455872887018193 0.333776137986438 no 1144 0.324240693698959 1511 3116166
SGTC_1520 flindersine 88 µM 0.455021929119343 0.334088628122088 no 1145 0.324546731285705 1705 68230 Flindersine is a natural alkaloid of the quinoline subtype.
SGTC_1399 3562-5772 25 µM 0.454770788435812 0.334180874408014 no 1146 0.324637073911036 1506 23847490
SGTC_880 0833-0487 87.2 µM 0.454572726912597 0.334253631294756 no 1147 0.324708329693099 1522 76075
SGTC_3127 9126946 49.47 µM 0.454490850791279 0.334283709888337 no 1148 0.32473778780393 1485 27243249
SGTC_3277 9138724 49.47 µM 0.454468512182604 0.334291916543087 no 1149 0.324745825175322 1536 15943418
SGTC_2429 5902844 64.44 µM 0.452995764520236 0.33483314235351 no 1150 0.325275895699131 1655 1927790 YGL093W | YPR107C SPC105 | YTH1
SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM 0.450976157920263 0.335575893471796 no 1151 0.326003366379209 1635 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_2882 9058044 58.44 µM 0.450060119635315 0.335912997185204 no 1152 0.326333545831618 1469 18076804
SGTC_3339 9145883 14.936 µM 0.449808556073957 0.33600559614432 no 1153 0.32642424395778 1606 2030670
SGTC_67 0335-0847 266 µM 0.449776785251717 0.33601729149153 no 1154 0.32643569926428 1784 4552207 YOR254C SEC63
SGTC_2293 7624732 200 µM 0.449109466620151 0.336262978813421 no 1155 0.326676345879528 1475 894453
SGTC_3142 9086498 49.47 µM 0.446527195026003 0.337214354384129 no 1156 0.3276082364269 1566 25236367
SGTC_3324 9138759 60.749 µM 0.445662355473686 0.337533216839782 no 1157 0.327920580434435 1569 45595710
SGTC_904 1141-0088 396 µM 0.445175594277928 0.337712734839778 no 1158 0.328096431263289 1469 1378119
SGTC_295 k015-0027 31 µM 0.443562955500491 0.338307741232009 no 1159 0.328679296766564 1551 3887424
SGTC_3059 1327-0034 3 µM 0.442610781615499 0.338659249349551 no 1160 0.329023642475409 1511 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_35 0133-0054 64.071 µM 0.442165712783028 0.338823600878228 no 1161 0.329184647686171 1473 99677
SGTC_2652 actinonin 100 µM 0.441702520345484 0.338994677539056 no 1162 0.329352242824072 1573 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase.
SGTC_3238 9133470 49.47 µM 0.440102023106031 0.33958606464861 no 1163 0.329931608364398 1649 3534688
SGTC_1020 4335-0961 93.3 µM 0.438477649271543 0.340186678314955 no 1164 0.33052003442941 1498 669075
SGTC_1367 1812-0510 76.9 µM 0.437104855715132 0.340694586368674 no 1165 0.331017652993462 1587 1142582 YDR527W RBA50
SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM 0.435844598647608 0.341161112469934 no 1166 0.331474741627873 1670 756377
SGTC_3106 9121286 49.47 µM 0.435697430507858 0.341215607508109 no 1167 0.331528135128019 1625 15943471
SGTC_621 3584-0052 32.1 µM 0.435361402972683 0.341340047893473 no 1168 0.331650060802448 1654 2273927
SGTC_2093 5331342 194.4 µM 0.435322257604123 0.341354545639515 no 1169 0.331664265636427 1647 33839
SGTC_2044 5102272 200 µM 0.435162787850443 0.34141360873656 no 1170 0.33172213555516 1565 592666
SGTC_2717 st081029 62.2815 µM 0.434103266089404 0.341806124276016 no 1171 0.332106726931795 1627 5292846
SGTC_1331 1472-0049 76.2 µM 0.433590372858917 0.341996194655003 no 1172 0.332292963478523 1543 24051409
SGTC_266 formosanin C 406 nM 0.433168032609434 0.342152737555129 no 1173 0.33244635045123 1581 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1
SGTC_1527 coumarin 137 µM 0.432318840315969 0.342467577778576 no 1174 0.332754847925509 1632 323 A hepatotoxic, DNA x-linker.
SGTC_1739 st037196 92.5 µM 0.430133030389265 0.343278475622607 no 1175 0.333549437017619 1725 612214
SGTC_1474 0330-0125 5.35 µM 0.429762788222213 0.3434159007051 no 1176 0.333684102144729 1563 X1474
SGTC_1444 4112-3581 28 µM 0.429739222792515 0.343424648332868 no 1177 0.333692674129475 1595 2877249
SGTC_952 1185-0122 232 µM 0.429605892725762 0.343474142826813 no 1178 0.333741174913901 1531 678600
SGTC_2557 derrustone 83.84 µM 0.42840611440163 0.34391964255351 no 1179 0.334177736925684 1530 629853 An antioxidant.
SGTC_602 3130-1533 38.1 µM 0.426060252247721 0.344791330096804 no 1180 0.335031971174702 1667 720941
SGTC_1704 st028805 70.8 µM 0.424404283279981 0.34540716038031 no 1181 0.335635498747657 1579 2876101
SGTC_2079 5212404 121 µM 0.424001204904799 0.345557121272113 no 1182 0.33578246728021 1695 758462
SGTC_1759 st043059 70 µM 0.42344098741846 0.345765584303429 no 1183 0.335986772846924 1539 669426
SGTC_441 propafenone 146 µM 0.422415147177145 0.346147431832216 no 1184 0.336361011857542 1567 4932 Slows the influx of sodium ions into the cardiac muscle.
SGTC_2887 9044784 58.44 µM 0.42206807571897 0.346276657352858 no 1185 0.336487664490255 1555 6465546
SGTC_161 4065-0411 162.148 µM 0.421952220993062 0.346319797663242 no 1186 0.336529946099718 1657 1906281 YLR208W SEC13
SGTC_1319 1306-0155 43.7 µM 0.420720818244202 0.346778452768456 no 1187 0.336979478723057 1624 3122360
SGTC_1777 st045864 34.765 µM 0.418436193640939 0.347629991338691 no 1188 0.337814114328303 1604 4691462
SGTC_485 niflumic acid 177 µM 0.416913266647839 0.348198053208178 no 1189 0.338370924686771 1636 4488 A COX2 inhibitor.
SGTC_61 0978-8327 98.565 µM 0.415505041080192 0.348723633960462 no 1190 0.338886112797118 1625 6150059 YHR072W ERG7
SGTC_534 k292-0788 63.4 µM 0.414937930945501 0.34893537403095 no 1191 0.339093670739363 1762 4146317
SGTC_776 4476-4378 112 µM 0.41430009835311 0.349173575731043 no 1192 0.339327170918349 1587 2892008
SGTC_2826 7992541 19.48 µM 0.41413168631563 0.349236479951404 no 1193 0.339388834138402 1644 2985066
SGTC_3045 9092950 49.47 µM 0.413777859491375 0.349368652644177 no 1194 0.33951840005782 1725 44120432
SGTC_42 0133-0086 60.653 µM 0.413425310434135 0.349500366194142 no 1195 0.339647516946645 1515 162923 Model of phenazepam hydroxylation.
SGTC_566 0958-0068 16.5 µM 0.413052741523408 0.349639578925816 no 1196 0.339783986321805 1644 6815365
SGTC_2834 9001755 58.44 µM 0.412431175684572 0.34987187593865 no 1197 0.340011708263781 1617 2989575
SGTC_1892 st058411 7.36 µM 0.407898779965761 0.351567456750685 no 1198 0.341673994251859 1693 3934738
SGTC_2959 9079155 11 µM 0.40661068771411 0.352049876521916 no 1199 0.342146973127947 1627 16189457
SGTC_1263 0774-1208 64.8 µM 0.403415951271888 0.353247404529836 no 1200 0.343321127036674 1759 906585
SGTC_2193 5925765 200 µM 0.403134165216343 0.353353100338926 no 1201 0.343424764014239 1676 877370
SGTC_2403 6032726 181.2 µM 0.402255505979493 0.353682751336876 no 1202 0.343747998177968 1604 2881040
SGTC_2127 5253358 187.912 µM 0.401878347386149 0.35382428550096 no 1203 0.34388677934103 1578 20612
SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM 0.401302308564164 0.354040491309345 no 1204 0.344098782063651 1588 803109
SGTC_2585 alliin 100 µM 0.400268021455856 0.354428810456074 no 1205 0.34447955938249 1726 87310 A garlic compound which reacts with lipids.
SGTC_2422 chlorphenesin carbamate 384.24 µM 0.399721792644485 0.354633951086629 no 1206 0.344680719551187 1607 2724 A muscle relaxant with antifungal properties.
SGTC_2111 5486399 200 µM 0.398323218240686 0.355159389051874 no 1207 0.345195973885682 1603 689674
SGTC_2784 7567673 72.73 µM 0.398141156011554 0.355227809282013 no 1208 0.345263069291581 1604 3471247
SGTC_149 3970-0822 46.1 µM 0.397244700969393 0.35556477124728 no 1209 0.345593510828077 1640 3114250 YBL034C STU1
SGTC_2463 5473429 200 µM 0.397056858400453 0.355635392342001 no 1210 0.345662766241032 1626 5399405
SGTC_587 k089-0003 57 µM 0.394792687279472 0.356487016982208 no 1211 0.346497946093421 1672 9659696
SGTC_1700 st030840 7.9285 µM 0.393714678631033 0.35689274121125 no 1212 0.346895851464834 1757 5499307
SGTC_963 1269-2853 151 µM 0.393058705811507 0.357139705395414 no 1213 0.347138061257214 1577 3668223
SGTC_2638 epoxomicin 18 µM 0.392667237266284 0.357287116114249 no 1214 0.347282635905622 1733 9915668 A protesome inhibitor.
SGTC_2479 5617353 43.85 µM 0.392524637516621 0.357340818523497 no 1215 0.347335305452662 1694 2731746
SGTC_558 k064-0027 21.3 µM 0.392359009310895 0.357403196890023 no 1216 0.347396484313905 1698 5088526
SGTC_3113 9123498 49.47 µM 0.391464633888057 0.357740099510085 no 1217 0.347726912591431 1661 8897275
SGTC_2187 6125751 200 µM 0.390899048682119 0.357953207255184 no 1218 0.347935928589928 1663 874498
SGTC_939 1165-0479 45.3 µM 0.388640442619336 0.358804671849724 no 1219 0.348771072598066 1695 1377347
SGTC_1034 k072-0165 12.7 µM 0.387936438727272 0.359070215735039 no 1220 0.349031535744124 1778 5835461
SGTC_2824 7998404 51.95 µM 0.387308673993362 0.359307060349501 no 1221 0.349263852391039 1665 837851
SGTC_2998 9066762 71.4286 µM 0.387254026342976 0.359327680508378 no 1222 0.34928407849943 1738 4945196
SGTC_209 4077-0173 175.592 µM 0.387181437871995 0.359355070897815 no 1223 0.349310945499972 1657 15993494
SGTC_2999 9069765 71.4286 µM 0.387060540581492 0.359400691645503 no 1224 0.349355694606669 1715 2097066
SGTC_481 bay k-8644 50 µM 0.386105799653302 0.359761034724604 no 1225 0.349709157384987 1597 2303 A calcium channel antagonist.
SGTC_2261 9010538 184.68 µM 0.384831929942289 0.360242019126662 no 1226 0.350180970445838 1579 6457250
SGTC_2881 9058953 51.95 µM 0.384433330363568 0.360392566807612 no 1227 0.350328650432723 1565 17122249
SGTC_2969 9091408 28.7 µM 0.382765280965277 0.361022809519164 no 1228 0.35094690318124 1576 4286311
SGTC_100 0086-0128 49.5915 µM 0.38257654977224 0.361094142037801 no 1229 0.351016880186683 1555 93297
SGTC_2280 7785178 200 µM 0.381144310821814 0.361635625892156 no 1230 0.351548084595627 1669 2954328
SGTC_896 0964-0007 44.5 µM 0.381097504087714 0.36165332670834 no 1231 0.351565449687506 1739 6756758
SGTC_2949 9072542 2.23 µM 0.380318043587002 0.36194813733349 no 1232 0.351854671599561 1609 16457352
SGTC_2928 9011484 9.79 µM 0.376329503562017 0.363457977620407 no 1233 0.353335974021193 1659 2994751
SGTC_2073 5212005 126 µM 0.373985835963959 0.364346152436514 no 1234 0.354207427046455 1753 691789
SGTC_2634 4'-methoxyflavone 100 µM 0.373145022098457 0.364664971823013 no 1235 0.354520255881115 1656 77793 From seeds of Psoralea corylifolia (Fabaceae)
SGTC_1867 st057372 64 µM 0.373056876095332 0.364698400406628 no 1236 0.35455305671287 1671 688837
SGTC_93 0109-0045 59.227 µM 0.372656070615127 0.364850415272129 no 1237 0.354702217779921 1695 88733
SGTC_645 0845-0943 5.41 µM 0.372185361591704 0.365028969822263 no 1238 0.354877422125617 1665 1885106
SGTC_1010 4112-3296 15.2 µM 0.370016299062762 0.365852140261993 no 1239 0.355685173029324 1829 704384
SGTC_290 2043-6722 48.1 µM 0.368628406322509 0.366379177212568 no 1240 0.356202359640271 1692 773758 YLR208W SEC13
SGTC_2242 6630449 61.2675 µM 0.366147981092995 0.367321718695804 no 1241 0.3571273279624 1712 691249 YDR170C SEC7
SGTC_640 3381-0960 37.1 µM 0.366000813942567 0.367377666215849 no 1242 0.357182234106261 1758 1745025
SGTC_2995 9067767 71.4286 µM 0.365603804692537 0.36752860852214 no 1243 0.357330367825852 1694 11673567
SGTC_1147 3809-1045 12.3 µM 0.36508017235955 0.367727724027625 no 1244 0.357525780550018 1650 325925
SGTC_1769 st044406 64.4 µM 0.364274574580885 0.3680341286303 no 1245 0.357826492020147 1684 670903
SGTC_2635 hydroquinidine 100 µM 0.363053096903591 0.368498870967528 no 1246 0.358282610379508 1670 442912 An experimental heart treatment.
SGTC_2764 methyldopa 94.69 µM 0.361605692032802 0.369049822147344 no 1247 0.358823355252524 1788 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent.
SGTC_2879 9041815 71.43 µM 0.358830239121281 0.370107043670906 no 1248 0.359861044788126 1678 4942971
SGTC_529 4076-0302 30.3 µM 0.357095492427328 0.370768340244032 no 1249 0.360510159423417 1670 5816522
SGTC_2122 5258151 111.688 µM 0.355297774598048 0.371454044816063 no 1250 0.36118326123283 1659 2173356
SGTC_2453 5731132 22.18 µM 0.354270260857186 0.371846153447628 no 1251 0.361568176374254 1832 1362040
SGTC_48 0382-0018 55 µM 0.353717823486146 0.372057023585466 no 1252 0.361775181930797 1811 762596
SGTC_2576 guaiol 23.12 µM 0.352967802586582 0.372343374483536 no 1253 0.362056289371285 1862 227829
SGTC_1119 parthenolide 318.541 nM 0.352112276130014 0.372670092588909 no 1254 0.362377031100866 1770 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs.
SGTC_384 k007-0144 5.16 µM 0.349055855672447 0.373838059897386 no 1255 0.363523688359369 1717 6824886
SGTC_1579 chlormadinone acetate 49.4 µM 0.348912062272754 0.373893037125039 no 1256 0.363577664607979 1819 45114258 A steroidal progestin.
SGTC_1528 arabinosylhypoxanthine 74.6 µM 0.347546544485121 0.374415249881823 no 1257 0.364090378791076 1775 804 An inhibitor of viral and cellular DNA polymerases.
SGTC_657 3534-0529 86.7 µM 0.345552461638039 0.375178257549458 no 1258 0.364839538761827 1782 1049549
SGTC_1994 st072947 40.9 µM 0.345305781088002 0.375272680406872 no 1259 0.364932250492172 1757 5286565 YDL195W SEC31
SGTC_310 1273-0058 1.06 µM 0.345077784089064 0.375359958336296 no 1260 0.365017947271816 1723 2734232
SGTC_2649 anisomycin 9.56 µM 0.344112976189361 0.375729360248072 no 1261 0.365380662292324 1717 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_425 3825-7017 13.1 µM 0.340075648513281 0.377276388981644 no 1262 0.366899779853826 1773 3397440
SGTC_524 r073-0010 27.8 µM 0.338477124647988 0.377889459801654 no 1263 0.367501831382547 1682 2772106
SGTC_1104 tacrolimus 29.8 µM 0.337390357918869 0.378306435738438 no 1264 0.367911326131409 1749 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41
SGTC_18 0111-0177 500 nM 0.337302397900607 0.378340190873123 no 1265 0.367944476125901 1736 721752
SGTC_506 n9-isopropylolomoucine 153 µM 0.33595166010933 0.378858660294348 no 1266 0.368453659775031 1895 6610355
SGTC_1822 st052468 42 µM 0.333242038678489 0.379899382492249 no 1267 0.369475793777468 1714 2873678
SGTC_341 1486-1430 230 µM 0.332357941048759 0.38023913893191 no 1268 0.369809496658266 1675 2054753 YPL210C SRP72
SGTC_2869 9037858 32.47 µM 0.331687971127052 0.380496668220132 no 1269 0.370062442309115 1682 27187042
SGTC_1582 3',3',6'-trihydroxyflavone 74 µM 0.330080889491998 0.381114628980633 no 1270 0.370669421362454 1699 688803
SGTC_1576 erythromycin ethylsuccinate 23.2 µM 0.329506715344689 0.381335486092353 no 1271 0.370886359497583 1731 3256 An antibiotic and ribosome inhibitor.
SGTC_2411 st077133 39.94 µM 0.327968575784708 0.381927324494166 no 1272 0.371467711277162 1881 1403142 YNL221C POP1
SGTC_1321 1326-2144 215 µM 0.327851545637423 0.381972366144549 no 1273 0.371511955753407 1840 3513030
SGTC_2860 9025725 38.96 µM 0.327345313426796 0.38216721924482 no 1274 0.371703361704322 1665 40546248
SGTC_2748 diazoxide 86.69 µM 0.324553182211789 0.383242469445659 no 1275 0.372759632830888 1793 3019 A potassium channel activatior.
SGTC_3227 9130768 49.47 µM 0.323891280780241 0.383497500085577 no 1276 0.373010172701673 1792 17720899
SGTC_1944 st076371 56.9 µM 0.32307790675793 0.383810962245892 no 1277 0.373318120830752 1683 24208455
SGTC_2446 5162541 200 µM 0.322614332041737 0.383989651028438 no 1278 0.373493669131393 1706 1549321
SGTC_1664 st014217 9.02 µM 0.322201573265207 0.384148773137972 no 1279 0.373649996349526 1800 3982782
SGTC_2981 9013952 38.96 µM 0.322192219636132 0.384152379269977 no 1280 0.373653539160424 1630 2996344
SGTC_3196 9111891 49.47 µM 0.315363884637739 0.386787584132443 no 1281 0.376242692339533 1765 18891510
SGTC_339 3091-4833 71.4 µM 0.314611681757376 0.387078197670755 no 1282 0.376528254254054 1795 3240077
SGTC_2710 st078562 53.7235 µM 0.313149040363463 0.387643470195278 no 1283 0.377083716254077 1720 17250908
SGTC_222 nsc-310342 10.666 µM 0.312675270059504 0.387826621128142 no 1284 0.377263692893837 1872 432556
SGTC_1018 4259-0013 28.1 µM 0.312522436237581 0.387885709214257 no 1285 0.377321757346382 1779 6801262
SGTC_233 rapamycin 362 pM 0.310595726995928 0.388630829135126 no 1286 0.378053988001511 1807 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C
SGTC_3016 9080866 49.47 µM 0.30957466098035 0.389025874309054 no 1287 0.378442213940687 1723 17066299
SGTC_2158 5657123 3.6195 µM 0.30856991565706 0.389414717117008 no 1288 0.378824354297665 1829 2858827
SGTC_2864 9034755 47.6 µM 0.307559249155141 0.389805963191829 no 1289 0.379208866233094 1910 4930451
SGTC_2142 5622915 118.518 µM 0.306734326740835 0.390125387393747 no 1290 0.379522799740958 1749 5322196
SGTC_2387 9077560 195.08 µM 0.306622205185077 0.390168808528705 no 1291 0.379565474997874 1734 5303272
SGTC_1332 1480-0653 17.5 µM 0.306495835725742 0.390217749068929 no 1292 0.379613574993348 1895 5749438
SGTC_3274 9138298 49.47 µM 0.305795100587752 0.390489162303253 no 1293 0.379880329532227 1771 17015756
SGTC_2444 5485484 36.41 µM 0.305533738402798 0.390590408456781 no 1294 0.37997983904275 1841 6790631
SGTC_2189 6047310 154.431 µM 0.304683888732548 0.390919673397693 no 1295 0.380303460736189 1778 711535
SGTC_2513 baicalein 25.65 µM 0.303967503087441 0.391197289929227 no 1296 0.380576324603218 1683 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2
SGTC_2146 5545642 200 µM 0.303353584415245 0.391435242184632 no 1297 0.380810207150181 1813 825326
SGTC_1605 st000082 49.1 µM 0.303196607504825 0.391496092291281 no 1298 0.380870017116091 1842 1114022
SGTC_314 1671-0008 2.74 µM 0.301385188848791 0.392198457482074 no 1299 0.381560393583769 1801 3913060
SGTC_2353 9059630 146.67 µM 0.300694441220965 0.392466382813708 no 1300 0.381823753998748 1855 4779114
SGTC_905 2-aminofluorene 215 µM 0.300195800332404 0.392659825989056 no 1301 0.382013904143674 1746 1539 An established DNA mutagen. YPR165W RHO1
SGTC_2096 5468907 200 µM 0.30003283879808 0.392723051178747 no 1302 0.38207605355528 1899 759785
SGTC_415 dibenzyl ketone 100 µM 0.299026138462824 0.393113689603715 no 1303 0.382460050938425 1898 7593
SGTC_1646 st011709 75.6 µM 0.296766958133914 0.393990729732904 no 1304 0.383322216601222 1900 5757843
SGTC_3114 9122766 49.47 µM 0.296180754583533 0.394218388855266 no 1305 0.38354602272648 1741 17176985
SGTC_1678 st019265 80.2 µM 0.295138572522299 0.394623221863061 no 1306 0.383944012391275 1947 5367020
SGTC_1373 2887-0003 58.5 µM 0.295110019690037 0.394634314743077 no 1307 0.383954917904114 1788 776948
SGTC_1963 st076565 50.3 µM 0.294915734670282 0.394709797453551 no 1308 0.384029125864065 1753 4914280
SGTC_1942 st076330 65.2 µM 0.294089695719481 0.395030770355363 no 1309 0.384344682268695 1841 24208414
SGTC_1628 st004252 77.7 µM 0.293639368728852 0.395205783361642 no 1310 0.384516744675652 1896 692968
SGTC_2561 acetosyringone 100 µM 0.293622887827137 0.39521218882456 no 1311 0.384523042184195 1781 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent.
SGTC_3023 9089636 49.47 µM 0.293471340567192 0.395271090469736 no 1312 0.384580951254961 1898 17249241
SGTC_875 0709-0210 25.7 µM 0.293235040997714 0.395362937441263 no 1313 0.384671250922588 1936 6251364
SGTC_1375 2910-0797 186 µM 0.29276568580894 0.395545387732348 no 1314 0.384850629165604 1808 742508
SGTC_2355 9061122 103.12 µM 0.29213708527098 0.395789776596235 no 1315 0.385090906430146 1896 5302957
SGTC_671 0560-0003 407 µM 0.289987414126707 0.396625840137572 no 1316 0.385912933089827 1859 3238678
SGTC_1587 estradiol valerate 56.1 µM 0.289828413598226 0.396687698549432 no 1317 0.385973754732617 1935 13791 A steroid.
SGTC_1903 st060211 78.3 µM 0.289541433215281 0.396799353505604 no 1318 0.386083538935561 1911 688960
SGTC_1222 0366-0074 1.18 µM 0.289270799229461 0.396904656350057 no 1319 0.386187078190555 1918 286520
SGTC_1407 3909-7909 12.3 µM 0.288584423232018 0.397171756815794 no 1320 0.386449708518266 1782 4411780
SGTC_13 0199-0087 65 µM 0.285883099350217 0.398223433519524 no 1321 0.387483829270011 1843 4589825
SGTC_2065 5221596 34.26 µM 0.285793423400888 0.398258358798508 no 1322 0.387518172754491 1824 788581
SGTC_1660 st012960 28.1 µM 0.285026547958025 0.398557060085816 no 1323 0.387811901411927 1808 24207266
SGTC_444 curcumin 90.4 µM 0.284975107144059 0.398577098633517 no 1324 0.387831606573974 1842 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties.
SGTC_3029 9088683 49.47 µM 0.284406574667117 0.398798585811103 no 1325 0.388049410547871 1821 25236615
SGTC_1240 0356-0016 42.1 µM 0.284193888745065 0.398881451736124 no 1326 0.388130899274518 1825 4305613
SGTC_1677 st019204 53.9 µM 0.283620386829182 0.399104920198534 no 1327 0.388350655990936 1732 3945625
SGTC_3239 9133757 49.47 µM 0.283487257113217 0.399156799723214 no 1328 0.388401674273088 1871 17036923
SGTC_2472 5377652 49.4 µM 0.282183010013518 0.399665147858369 no 1329 0.38890159261223 1786 1610903
SGTC_2727 riluzole 51.77 µM 0.280613768917785 0.40027700644811 no 1330 0.389503327070322 1902 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.
SGTC_311 1315-0136 58 µM 0.280002343906534 0.400515471902359 no 1331 0.389737853307203 1891 6759207
SGTC_182 3448-4371 550.524 µM 0.279958308157619 0.40053264797577 no 1332 0.389754745790618 2006 3491403
SGTC_1207 2099-0101 141 µM 0.279197704375745 0.400829350589306 no 1333 0.390046552632065 1942 5837381
SGTC_2872 9044037 25.97 µM 0.277479564202209 0.401499787276552 no 1334 0.390705947696704 1900 6465195
SGTC_1621 st003705 32.4 µM 0.276219199025896 0.401991779811996 no 1335 0.391189855982235 1941 24207032
SGTC_1208 2323-2347 50.3 µM 0.274963176488116 0.402482231717207 no 1336 0.391672264569136 1957 5412760
SGTC_2063 5246145 200 µM 0.274851201479389 0.402525963203901 no 1337 0.391715279625185 1878 711240
SGTC_1011 4112-3381 17.4 µM 0.274683311059581 0.402591534563531 no 1338 0.391779776995115 1860 2877139
SGTC_2273 7815444 169.05 µM 0.27340947482235 0.403089133779779 no 1339 0.392269235152101 1957 2824616
SGTC_2876 9059903 25.97 µM 0.273083591780218 0.403216458866306 no 1340 0.39239447969624 1845 6916095
SGTC_458 nppb 133 µM 0.272229668204071 0.403550142212787 no 1341 0.392722715518458 1984 4549 A chloride channel blocker.
SGTC_460 trequinsin 123 µM 0.271602788163205 0.403795149631102 no 1342 0.392963727689389 1893 5537 A vasodilator.
SGTC_1427 4048-4900 550 nM 0.270710389917142 0.404143996281527 no 1343 0.393306892553578 1951 24132586
SGTC_64 000l-0018 272.079 µM 0.26907814709511 0.404782252019873 no 1344 0.393934773277427 1793 6811119
SGTC_2413 inermin 26.06 µM 0.26892415655415 0.404842480032773 no 1345 0.393994023636141 1966 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1
SGTC_2951 9072950 58.06 µM 0.26747349033409 0.405409967834105 no 1346 0.394552311253551 1934 16488155
SGTC_1964 st076914 61 µM 0.267466349635092 0.405412761705341 no 1347 0.394555059882046 1873 24208661
SGTC_2911 7942208 15.64 µM 0.267265351203158 0.405491406366325 no 1348 0.394632431213935 1805 1243384
SGTC_1802 st050112 57.9 µM 0.266364698272685 0.40584385166864 no 1349 0.394979175050886 1907 4662563
SGTC_1065 prochlorperazine maleate 2.48 µM 0.265305038291561 0.406258617646608 no 1350 0.395387241773904 1845 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine.
SGTC_2855 9016525 58.44 µM 0.265294903818116 0.406262584932243 no 1351 0.395391145034499 1841 43811474
SGTC_2531 methyl deoxycholate 70.07 µM 0.264496100250818 0.406575318339213 no 1352 0.395698834700138 1806 16667744 Haematoxylin.
SGTC_2888 9058547 12.99 µM 0.260540184824891 0.408124942870064 no 1353 0.397223561134931 1800 16476514
SGTC_2002 4023503 131 µM 0.259556048848842 0.408510676259705 no 1354 0.397603121250725 2041 4736863 YCR052W RSC6
SGTC_580 1123-0028 41 µM 0.259408939719946 0.408568343501656 no 1355 0.397659866422185 1902 1677248 YPR107C YTH1
SGTC_3031 9088762 49.47 µM 0.259402976854603 0.408570681005412 no 1356 0.397662166555005 1853 205253
SGTC_3132 9126706 49.47 µM 0.256112101721045 0.40986123148 no 1357 0.39893213886674 1883 850858
SGTC_1063 disulfiram 1.84 µM 0.255746149594016 0.410004803988395 no 1358 0.399073428811849 1858 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_1372 2752-0194 270 µM 0.254474892325896 0.410503644817907 no 1359 0.399564349399877 1850 823334
SGTC_943 3253-1379 105 µM 0.254360177549886 0.41054866598443 no 1360 0.399608656554335 1928 668464
SGTC_3112 9123419 49.47 µM 0.252671015448068 0.411211733728648 no 1361 0.400261223781445 1894 17015854
SGTC_1059 3448-6867 171 µM 0.25126629830878 0.411763338087968 no 1362 0.400804114760699 2026 3934407
SGTC_170 4197-0004 226 µM 0.251020883094463 0.411859725668561 no 1363 0.400898981811033 1906 218692
SGTC_2831 7999036 19.48 µM 0.250382876899472 0.412110329435735 no 1364 0.401145635116219 1989 2988270
SGTC_429 1112-0049 25.5 µM 0.250150763608208 0.412201510591162 no 1365 0.40123537993542 1796 2836170
SGTC_1691 st019933 84.6 µM 0.249826098126761 0.412329057009943 no 1366 0.401360918088288 2010 6176082
SGTC_2961 9083290 32.55 µM 0.249421453245553 0.412488036687225 no 1367 0.401517396067417 1899 17741490
SGTC_346 4513-0042 7.16 µM 0.248830997655856 0.412720044715678 no 1368 0.401745756206446 1829 2827372
SGTC_1235 benzylparaben 21.5 µM 0.248172368086537 0.41297887635839 no 1369 0.402000522383765 1879 7180
SGTC_2275 7947463 200 µM 0.248091343295503 0.413010720514083 no 1370 0.402031866667945 1986 1225414
SGTC_2223 6903751 107.57 µM 0.243371605097112 0.414866641006855 no 1371 0.403858769236986 1934 5598863
SGTC_681 1642-0006 26.6 µM 0.242348087511006 0.415269366369542 no 1372 0.404255227812611 1939 4446530
SGTC_1698 5-fluorocytosine 1.055 µM 0.241539438155407 0.415587610114997 no 1373 0.40456852694937 1999 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_2298 7976326 193.81 µM 0.240792118324108 0.415881766883131 no 1374 0.404858119294162 1943 2235818
SGTC_2556 citropten 84.59 µM 0.238621411153877 0.416736457885282 no 1375 0.405699580485016 1784 2775 A potential DNA crosslinker.
SGTC_3267 9137951 49.47 µM 0.238387992698526 0.416828387236877 no 1376 0.405790089730608 1884 16643986
SGTC_2252 omeprazole 400 µM 0.237379061246558 0.417225796308553 no 1377 0.406181366133115 1964 4594 A proton pump inhibitor.
SGTC_2143 5623677 140.463 µM 0.236080733217949 0.417737320500646 no 1378 0.406685012043401 1981 5375313
SGTC_2078 5212016 200 µM 0.235864578268781 0.417822496253458 no 1379 0.406768877635696 2024 1899708
SGTC_174 3553-0389 74.3 µM 0.234592467004887 0.418323849057325 no 1380 0.407262528436298 1937 738071
SGTC_3178 9107506 49.47 µM 0.233423071637535 0.418784837523454 no 1381 0.407716449679132 1927 8897194
SGTC_2651 TUB2.036 5 µM 0.232787712440994 0.419035349886955 no 1382 0.407963127444635 2012 15992207 YFL037W TUB2
SGTC_509 pifithrin 175 µM 0.232067121663796 0.419319507478814 no 1383 0.408242940464437 1931 4817 A p53 inhibitor.
SGTC_268 camptothecin 39.6153 µM 0.231930516345486 0.419373381136569 no 1384 0.408295991034984 1899 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_81 0411-0046 9.971 µM 0.23035583094494 0.419994505830652 no 1385 0.408907640024396 1931 12925265
SGTC_3104 9120930 49.47 µM 0.22983956237157 0.420198188167156 no 1386 0.40910822061264 1923 17014836
SGTC_969 1313-0238 134 µM 0.228033610664683 0.420910854239507 no 1387 0.40981005562477 1886 5212874
SGTC_1148 3909-7663 27.7 µM 0.227808414887461 0.420999739400083 no 1388 0.409897592279392 2011 4084526
SGTC_2164 5685496 200 µM 0.227083721109262 0.42128580458991 no 1389 0.410179321043831 1993 759046
SGTC_2206 7254556 146.969 µM 0.226398443305871 0.421556348971374 no 1390 0.410445769282271 2009 4398905
SGTC_814 3342-0569 96 µM 0.225173749950154 0.422039944173287 no 1391 0.41092205479761 1940 4346283
SGTC_946 3434-1334 87.4 µM 0.223981000216448 0.422511038803802 no 1392 0.411386043652796 1972 4047976
SGTC_283 0987-0079 11.7 µM 0.223344906867403 0.422762318906478 no 1393 0.411633539603278 2005 411556
SGTC_2179 6298986 200 µM 0.221660382511438 0.423427919115676 no 1394 0.412289136532264 2038 738374
SGTC_62 0180-0423 3.232 µM 0.219174965844406 0.424410371731872 no 1395 0.413256877875039 1971 30102 YGL099W LSG1
SGTC_1426 4048-4480 71.7 µM 0.219111231901575 0.424435571128256 no 1396 0.413281700781956 1993 14224343
SGTC_3008 9078912 71.4286 µM 0.218100633357126 0.424835187076221 no 1397 0.41367535196776 1885 16648731
SGTC_2303 7774051 200 µM 0.217222526789663 0.425182475127133 no 1398 0.414017464976018 2002 2953184
SGTC_970 1315-0089 19.5 µM 0.216410749435764 0.425503581867772 no 1399 0.414333793979177 1952 6811083 YLR033W RSC58
SGTC_2306 7482397 179.52 µM 0.216017314539536 0.425659226811676 no 1400 0.414487125566395 2011 891448
SGTC_2742 clothiapine 36.27 µM 0.215780455003099 0.425752935295862 no 1401 0.414579442038893 2032 16351 An atypical antipsychotic. YIL048W NEO1
SGTC_1052 3253-3998 198 µM 0.2153240221897 0.425933525141996 no 1402 0.414757350932623 1993 5450317
SGTC_3307 9126885 69.2785 µM 0.213623036593895 0.426606664834148 no 1403 0.415420516728861 1862 24824909
SGTC_2987 9018338 71.43 µM 0.212602406486154 0.427010666755879 no 1404 0.415818547126186 1987 5055682
SGTC_1289 0976-0073 69.1 µM 0.212357798455113 0.427107502759135 no 1405 0.415913953427093 1974 3391136
SGTC_1353 1498-1206 8.11 µM 0.211386809510827 0.427491943419845 no 1406 0.416292724341555 1931 6756808
SGTC_894 0960-0238 55.9 µM 0.211288698204455 0.427530792163432 no 1407 0.416331000693269 2034 6741907 YDL195W SEC31
SGTC_1350 1495-0454 146 µM 0.210416548122625 0.427876164804413 no 1408 0.416671289110316 2010 1069057
SGTC_540 1187-0821 17.3 µM 0.210143489235852 0.427984307874581 no 1409 0.416777841852581 1853 847520
SGTC_332 4112-0506 40.9 µM 0.210046367117897 0.428022773717538 no 1410 0.416815742214512 1934 2790355
SGTC_2405 ticlatone 3.52 µM 0.208602677915526 0.428594636620082 no 1411 0.417379209946543 1766 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W
SGTC_2785 7756463 72.73 µM 0.208380135961333 0.428682801571867 no 1412 0.417466082554869 1906 2201551
SGTC_1681 tripelennamine 100 µM 0.207931832225178 0.428860417883685 no 1413 0.417641096907764 2046 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist.
SGTC_525 k781-2675 26.7 µM 0.205752293656989 0.429724147798199 no 1414 0.418492203967462 2080 3651118 YDL195W SEC31
SGTC_2689 tacrolimus 100 µM 0.205333645380421 0.42989009268434 no 1415 0.41865572941745 1906 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12).
SGTC_3219 9131112 49.47 µM 0.205318915352238 0.429895931636734 no 1416 0.418661483273053 2052 17612988 YMR079W SEC14
SGTC_2091 4-phenylthiadiazole 200 µM 0.203650449019241 0.430557407131054 no 1417 0.419313333278857 1925 270010
SGTC_1960 st011366 51.8 µM 0.202665284803224 0.430948074213741 no 1418 0.419698329382037 1990 3972846
SGTC_1586 deoxycorticosterone acetate 53.7 µM 0.202462965000068 0.431028312551801 no 1419 0.419777404240734 2024 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE.
SGTC_3118 9124250 49.47 µM 0.201148467531721 0.431549700419728 no 1420 0.420291242395767 1934 1504786
SGTC_1937 st074714 47.2 µM 0.200670596458696 0.4317392748463 no 1421 0.420478076319159 1813 17250970
SGTC_1297 1068-0111 14.1 µM 0.200442645013314 0.431829710143408 no 1422 0.420567205129721 1897 767057
SGTC_1901 st060216 58.6 µM 0.199830222225076 0.432072694639509 no 1423 0.420806682046235 1901 688792
SGTC_1949 st076024 69.1 µM 0.19927729004116 0.432292097756617 no 1424 0.421022921411083 1837 2921930
SGTC_2314 7727897 200 µM 0.198633377295827 0.43254762821253 no 1425 0.421274771258443 1895 900724
SGTC_839 0122-0028 230 µM 0.197869421796701 0.432850833043103 no 1426 0.421573614504421 1980 759448
SGTC_1699 st031318 29.054 µM 0.197355904779163 0.433054664057702 no 1427 0.421774516909445 2023 5340658
SGTC_1855 st056195 39.6 µM 0.196898289880583 0.433236320777849 no 1428 0.421953565980775 2074 4028379
SGTC_2566 crystal violet carbinol 226 nM 0.195957736493111 0.433609731029269 no 1429 0.422321622996902 1798 68050 Cationic dye that binds acidic phospholipids including cardiolipin.
SGTC_2522 biochanin a 4.94 µM 0.195574772424026 0.43376178906029 no 1430 0.422471503812878 2012 5280373 A possible chelator.
SGTC_2016 5121758 140 µM 0.192492935178465 0.434985804815926 no 1431 0.42367805067317 2044 2795203
SGTC_3216 9129716 49.47 µM 0.191218732876725 0.435492063564301 no 1432 0.424177113846307 1951 8056934
SGTC_2003 4023581 200 µM 0.189443489425882 0.436197569222076 no 1433 0.42487262094799 1937 16641307
SGTC_3143 9086658 49.47 µM 0.187458189854455 0.436986794422053 no 1434 0.425650701104847 1922 25236626
SGTC_3256 9138902 49.47 µM 0.186562032669171 0.437343130239574 no 1435 0.426002018779886 2041 17228773
SGTC_47 0149-0135 24.25 µM 0.186064510220594 0.437540980295848 no 1436 0.426197086312095 1863 5239155
SGTC_1557 sumaresinolic acid 42.3 µM 0.186014128041765 0.437561016679401 no 1437 0.426216841056202 1938 9982268 A natural terpine and antifungal of unknown mechanisn.
SGTC_1117 retinoic acid 1.10837 µM 0.18385924761975 0.438418135792236 no 1438 0.427061937709193 2099 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR).
SGTC_428 3448-4153 16.5 µM 0.182760058212653 0.438855457780879 no 1439 0.427493144810523 1855 3834874
SGTC_1523 st012844 44.7 µM 0.182479908318545 0.438966929792654 no 1440 0.427603060238171 1984 4274103
SGTC_1166 k206-0078 225 µM 0.182102364601352 0.439117162591068 no 1441 0.42775119653892 1973 5404595
SGTC_1159 4092-0538 61.2 µM 0.182022444094388 0.439148965812247 no 1442 0.427782556143449 1973 717301
SGTC_1925 st057770 10.1 µM 0.181935386730807 0.439183609490292 no 1443 0.427816716662262 1831 5989122
SGTC_3079 9117512 49.47 µM 0.18150247565436 0.439355889388687 no 1444 0.427986595067021 2033 7185044
SGTC_1457 k015-0032 57.3 µM 0.181233992214656 0.439462739967222 no 1445 0.42809195721884 1958 4302660
SGTC_977 1348-1378 135 µM 0.180422776773752 0.439785612860366 no 1446 0.428410337224357 2061 X977
SGTC_273 hydroxyurea 18.1 mM 0.180197856905659 0.439875140605429 no 1447 0.428498620417957 1970 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12
SGTC_1308 1187-1617 41.4 µM 0.18008898578667 0.439918477080376 no 1448 0.428541354656068 1976 2882570
SGTC_1966 st070145 16.1 µM 0.178048644735624 0.440730773547279 no 1449 0.429342386525514 2012 3748532
SGTC_2947 9072639 7.68 µM 0.177891956933346 0.440793164136544 no 1450 0.429403913768795 1953 16488146
SGTC_1171 0368-0077 21.4 µM 0.176196218976902 0.441468473704637 no 1451 0.430069895569433 1973 3239779
SGTC_2001 4023502 57.655 µM 0.176055381221292 0.441524568521295 no 1452 0.430125216972858 2020 108941 YCR052W RSC6
SGTC_1120 ficusin 1.78878 µM 0.171342872008935 0.443402201429945 no 1453 0.431977085943905 2042 6199 A DNA cross-linker.
SGTC_1836 st055642 81 µM 0.170714042272339 0.443652846852521 no 1454 0.432224310390639 1907 8571
SGTC_217 ketoconazole 989 nM 0.170640218072735 0.443682273941688 no 1455 0.432253336121596 2061 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4
SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM 0.17053770257902 0.44372313819231 no 1456 0.43229364312014 2012 1377
SGTC_2049 5262831 67.185 µM 0.16880545863792 0.444413727379937 no 1457 0.432974832286926 1995 763417
SGTC_684 1140-0066 328 µM 0.168312562470766 0.444610259950479 no 1458 0.433168695713518 1987 6813534
SGTC_2032 5185112 25.99 µM 0.168297048936997 0.444616445885683 no 1459 0.433174797679445 2079 5718189
SGTC_2134 5324836 1.464 µM 0.168122026587758 0.444686236007034 no 1460 0.433243640635885 2039 699272
SGTC_220 paclitaxel 373.376 µM 0.168019858133232 0.444726976447492 no 1461 0.433283828317113 2091 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_2276 7947513 42.08 µM 0.167231751222841 0.445041259603672 no 1462 0.433593851162693 1845 2105100
SGTC_371 0195-0006 7.36 µM 0.167228234484736 0.445042662094465 no 1463 0.433595234657016 2003 3928593
SGTC_1449 4112-4002 201 µM 0.166973999344268 0.445144054020339 no 1464 0.433695253606332 1934 2059539
SGTC_2604 4'-hydroxychalcone 11.32 µM 0.166240088749424 0.445436766196112 no 1465 0.433984006044946 1986 5282362
SGTC_555 4296-0685 37 µM 0.165893512218817 0.445575004787288 no 1466 0.434120376624894 2098 2908540 YHR072W ERG7
SGTC_1733 st037357 54.9 µM 0.16567698166205 0.445661375446731 no 1467 0.434205580828279 1881 1272339 YGL099W LSG1
SGTC_2552 juarezic acid 87.02 µM 0.165451519387184 0.445751311569734 no 1468 0.43429430288755 2155 1549512
SGTC_1195 1502-0147 41.1 µM 0.164841239185864 0.445994764226175 no 1469 0.434534471922213 2011 817940
SGTC_3230 9131665 49.47 µM 0.164020982944321 0.446322012473416 no 1470 0.43485731275548 2056 15943720
SGTC_2324 6149169 200 µM 0.161702569071202 0.44724716052746 no 1471 0.435770040671456 2106 2888231
SGTC_661 1304-0007 33.6 µM 0.161461567972369 0.447343347016628 no 1472 0.435864939235568 1985 3117130
SGTC_2755 lomerizine 42.69 µM 0.161113263317692 0.447482365139624 no 1473 0.436002097049299 2006 3949 A calcium channel blocker.
SGTC_588 3970-1144 52.9 µM 0.159762793518523 0.448021436234761 no 1474 0.436533967008867 2119 1888707
SGTC_1845 st056753 3.01 µM 0.159318535063744 0.448198793254644 no 1475 0.436708959199055 1947 5375839
SGTC_2653 dihydrofissinolide 100 µM 0.158142417067567 0.448668373404246 no 1476 0.437172288571577 2054 6857746
SGTC_898 1000-0849 28.3 µM 0.158084238177108 0.448691603942484 no 1477 0.437195210273328 2132 6751807
SGTC_1469 k284-2957 126 µM 0.157305092952135 0.449002729632613 no 1478 0.437502203318056 2088 23884841
SGTC_518 1021-0119 62.6 µM 0.156897774004871 0.44916539138032 no 1479 0.437662707109117 1935 1097762
SGTC_1885 st057546 99.9 µM 0.156822764325815 0.449195347230271 no 1480 0.43769226574814 2120 702008
SGTC_365 0121-0052 13.6 µM 0.156791741245186 0.44920773668601 no 1481 0.437704490939316 2063 3101739
SGTC_1431 4049-0260 9.09 µM 0.156621257255395 0.449275822485763 no 1482 0.437771674218369 2058 3854841
SGTC_2854 9024559 71.43 µM 0.156540084094253 0.449308240949826 no 1483 0.43780366306752 1987 3163529
SGTC_707 0865-0008 204 µM 0.154262139056252 0.45021813056554 no 1484 0.438701524293401 2062 723043
SGTC_10 0279-0212 42.575 µM 0.154232784334245 0.450229857569803 no 1485 0.438713096644725 2107 39851 YBR002C RER2
SGTC_2455 5377712 9.75 µM 0.152908229531154 0.450759052929755 no 1486 0.439235323002467 1944 2243908
SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM 0.152643615996329 0.450864783693804 no 1487 0.439339663714847 2013 279621
SGTC_2668 2',4'-dihydroxychalcone 15.08 µM 0.151727577174585 0.451230829207419 no 1488 0.439700902773076 2082 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_835 0312-0010 67.2 µM 0.151510374553618 0.451317628615814 no 1489 0.439786563800216 2017 1626196
SGTC_591 4299-0174 154 µM 0.150963315671007 0.451536256850927 no 1490 0.440002327020933 2065 5509088
SGTC_385 1494-0393 12.4 µM 0.149836869277106 0.451986479456152 no 1491 0.440446660115227 2061 3090647
SGTC_1395 3486-0190 4.35 µM 0.148545134475514 0.452502841171427 no 1492 0.440956284433097 2147 6748079
SGTC_2763 lisinopril 49.32 µM 0.148452104554866 0.452540032326268 no 1493 0.440992991038231 2177 5362119 A lysine-analog of enalapril and an ACE inhibitor.
SGTC_390 dec-rvkr-cmk 16.7 µM 0.148247055971969 0.452622007354163 no 1494 0.441073898382896 2068 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1
SGTC_2741 miltefosine 3.04 µM 0.146989536667986 0.453124786787374 no 1495 0.44157013957085 2078 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis.
SGTC_2920 7982904 15.77 µM 0.146630905015525 0.453268188150739 no 1496 0.441711679330582 2040 6456808
SGTC_2922 7999257 32.47 µM 0.145332969202633 0.453787227625851 no 1497 0.442223992696375 2129 2988377
SGTC_349 k015-0014 24 µM 0.145041812844539 0.453903670790875 no 1498 0.442338929473147 2012 2196908
SGTC_1503 4585-0012 61.3 µM 0.144918451426102 0.453953008343496 no 1499 0.442387629045799 2106 2922052
SGTC_1446 4239-0190 62 µM 0.144269071515679 0.454212735079499 no 1500 0.442644000066598 1981 1340085
SGTC_937 3122-0005 46.7 µM 0.143835288066928 0.45438624252183 no 1501 0.442815268375964 2151 759535
SGTC_1001 4048-4355 44.4 µM 0.142248598894021 0.455020970375014 no 1502 0.443441822842464 2085 21824233
SGTC_2612 dictamnine 15.46 µM 0.142104505249954 0.455078618284501 no 1503 0.443498729809332 2042 68085 A quinoline derivative and established mutagen. YOR116C RPO31
SGTC_1729 st035615 45.989 µM 0.141054535640617 0.455498710773088 no 1504 0.44391342988127 2004 17385451
SGTC_1936 st074407 74.3 µM 0.140939062598764 0.455544914544222 no 1505 0.443959041319179 1992 809813
SGTC_651 3253-0966 34.4 µM 0.140870816283383 0.455572221954974 no 1506 0.443985998718341 2075 781462
SGTC_1763 st044482 94.5 µM 0.140760399484489 0.455616403493523 no 1507 0.444029614071924 2105 88505
SGTC_662 k832-1615 104 µM 0.140200783511586 0.4558403334178 no 1508 0.444250676433662 2084 5878478
SGTC_2501 sodium tetradecyl sulfate 13.37 µM 0.138403878709374 0.456559458057914 no 1509 0.444960615876464 2058 23665772 A membrane-active detergent.
SGTC_1592 4',5'-dihydroxyflavone 8.85 µM 0.138266758305364 0.456614339771746 no 1510 0.445014798081659 2020 688669
SGTC_1180 1193-0155 285 µM 0.137620569152995 0.456872984672503 no 1511 0.445270149188834 2052 2921347
SGTC_2867 9039098 71.43 µM 0.137574496995398 0.456891426301117 no 1512 0.445288356145164 2130 6463460
SGTC_2498 4'-Methoxychalcone 54.63 µM 0.137054848002992 0.457099436300961 no 1513 0.445493720833299 1942 641818 YHR062C RPP1
SGTC_1986 st071812 45 µM 0.135848315577421 0.457582443712319 no 1514 0.445970597382468 2167 11838594
SGTC_2087 5276107 200 µM 0.134392120682374 0.45816548111375 no 1515 0.44654625594967 2141 144405
SGTC_1522 st012842 45.6 µM 0.134230718455603 0.458230109577141 no 1516 0.446610067948325 1982 3491067 YOR116C RPO31
SGTC_2464 5717415 7.67 µM 0.133866334236389 0.458376019876091 no 1517 0.446754136006751 2027 5285744
SGTC_2367 9070478 135.38 µM 0.133733509639653 0.458429208198334 no 1518 0.446806653152018 2082 572802
SGTC_879 0831-1030 162 µM 0.132752267901922 0.458822159938403 no 1519 0.447194652415974 2075 1549252
SGTC_2262 9014885 67.46 µM 0.132369384847509 0.458975501655307 no 1520 0.447346064458058 2142 6457424
SGTC_1032 k061-1018 98.7 µM 0.13203038376562 0.459111274075563 no 1521 0.447480129672456 2194 4005393
SGTC_953 1188-0045 9.7 µM 0.13195877820763 0.459139953237494 no 1522 0.447508448387028 2107 6144426
SGTC_670 4204-0025 119 µM 0.131259780527172 0.459419924044527 no 1523 0.44778490347283 2133 719039
SGTC_1176 0848-0131 83.3 µM 0.129515764236943 0.460118545499084 no 1524 0.448474775975499 2194 6769040
SGTC_2053 5265679 138 µM 0.129188406563604 0.460249692867063 no 1525 0.448604284778646 2120 764595
SGTC_2615 purpurogallin-4-carboxylic acid 100 µM 0.129125400752187 0.460274935009241 no 1526 0.44862921168211 2166 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase.
SGTC_2935 9038016 29.96 µM 0.128812214575132 0.460400409777244 no 1527 0.448753120110824 2192 6463195
SGTC_1022 4477-0945 21.3 µM 0.128684325618058 0.460451648285622 no 1528 0.44880371931114 2028 4648966
SGTC_2130 NSC 7 2.4545 µM 0.128562075319812 0.460500628288168 no 1529 0.448852088357462 2163 21448
SGTC_1908 st060353 56.5 µM 0.128521872391415 0.460516735860722 no 1530 0.448867995047628 2198 4227716
SGTC_1005 4092-0690 4.4 µM 0.127300302743517 0.461006196692498 no 1531 0.449351360351201 2050 1529343
SGTC_1256 0570-0116 285 µM 0.127038187225762 0.46111122935644 no 1532 0.449455087177128 2062 410638
SGTC_3350 9150499 3.57 µM 0.126248506363615 0.461427679812186 no 1533 0.449767607988847 2184 4910996 YPR165W RHO1
SGTC_1717 st033143 58.0435 µM 0.125543222249102 0.461710330437524 no 1534 0.450046754642209 2165 674616
SGTC_1126 isoteolin 1.0172 µM 0.12534355253022 0.461790353865767 no 1535 0.450125787053618 2148 133323
SGTC_335 4077-0256 27.6 µM 0.124770261498597 0.462020125451979 no 1536 0.450352715631861 2175 3121989
SGTC_1548 st061468 90.8 µM 0.124183068440854 0.462255482026527 no 1537 0.450585163944057 2171 390799
SGTC_2507 purpurin 79.67 µM 0.123671945608391 0.462460359173348 no 1538 0.450787512630651 2098 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1
SGTC_572 0960-0087 17.7 µM 0.12364035911603 0.462473020548116 no 1539 0.450800017843897 2122 6796365
SGTC_3154 9100113 49.47 µM 0.123391743293086 0.462572678970748 no 1540 0.450898447503962 2074 25237525
SGTC_320 4092-0846 5.34 µM 0.122906471611601 0.462767208390005 no 1541 0.451090580440051 2167 1359356
SGTC_1968 st069590 43.6 µM 0.122130170443126 0.463078420433926 no 1542 0.45139796408375 2165 6384066
SGTC_798 1287-0182 476 µM 0.121957229456669 0.463147753979643 no 1543 0.451466445646409 2194 1649755
SGTC_748 act1.228 77.9 µM 0.121272009635414 0.463422475550662 no 1544 0.451737794719179 2090 4421505 YNR035C ARC35
SGTC_3346 9158254 43.5805 µM 0.120526646949361 0.463721329687011 no 1545 0.452032986145013 2104 17639500
SGTC_945 3381-0768 11.3 µM 0.119552946834609 0.464111766827182 no 1546 0.452418647635587 2190 1126236 YIL048W NEO1
SGTC_2042 p-Dimethylaminoacetophenone 200 µM 0.118111353565429 0.464689884500509 no 1547 0.452989713789575 2080 75037 A free radical scavenger.
SGTC_270 tamoxifen 5.46 µM 0.118022616621805 0.464725472849591 no 1548 0.453024868825003 2219 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen. YIL048W NEO1
SGTC_2171 5739187 198.077 µM 0.117452877569 0.464953975961007 no 1549 0.45325059187805 2148 2262761
SGTC_1805 st050013 60.3 µM 0.11743713390198 0.464960290379109 no 1550 0.453256829524829 2158 4037144
SGTC_2837 9008476 45.46 µM 0.117218342434256 0.465048043452854 no 1551 0.453343515979531 2123 2992805
SGTC_26 0302-0163 425.158 µM 0.116150698570968 0.465476279296774 no 1552 0.45376655451862 2124 3100915
SGTC_2491 paeonol 100 µM 0.116071284076096 0.465508134343771 no 1553 0.453798023473234 2088 11092 Increases levels of cortical cytochrome oxidase.
SGTC_2688 kanamycin b 96.69 µM 0.113767982769746 0.466432138744866 no 1554 0.454710859906015 2121 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis.
SGTC_1790 st045711 43.5 µM 0.112307889550986 0.467017971409297 no 1555 0.455289643212489 2203 585119
SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM 0.111642999482154 0.467284768761292 no 1556 0.455553238233884 2131 5393153
SGTC_2886 9058944 51.95 µM 0.11143808311988 0.4673669975675 no 1557 0.455634481076453 2214 4949929
SGTC_1165 k072-0275 30.3 µM 0.111115072796052 0.467496617926747 no 1558 0.455762548197432 2221 6153523 YGL055W OLE1
SGTC_231 b-estradiol 524 µM 0.11085856465521 0.467599554174304 no 1559 0.455864251810526 2100 450 A steroid.
SGTC_635 k038-0028 24.7 µM 0.110070270081769 0.467915908875211 no 1560 0.45617682295064 2139 4035102
SGTC_820 1582-0060 59.9 µM 0.109818544765543 0.468016934382942 no 1561 0.456276641702081 2105 3848840
SGTC_2693 st077581 40.7 µM 0.109454278014903 0.468163130052172 no 1562 0.456421092336759 2241 25238761
SGTC_3158 9100007 49.47 µM 0.108819289227114 0.468417988191295 no 1563 0.456672912041265 2108 19297233
SGTC_979 1426-2828 121 µM 0.108602705166824 0.468504919007614 no 1564 0.45675880751761 2147 747872
SGTC_1064 honokiol 6.76 µM 0.106746278089391 0.469250098362578 no 1565 0.457495133859704 2110 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis.
SGTC_3187 9109394 49.47 µM 0.103725598427892 0.47046284377381 no 1566 0.458693555808876 2118 17098090
SGTC_2792 7535235 81.82 µM 0.102789942448001 0.470838547954292 no 1567 0.45906484387252 2099 1281891
SGTC_1787 fluconazole 80 µM 0.102167345648032 0.471088560461178 no 1568 0.459311923245419 2156 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C
SGTC_1564 D-Arginine 115 µM 0.101994495683052 0.471157972822278 no 1569 0.459380522054356 2088 71070 D-isomer of arginine; arginine decarboxylase inhibitor.
SGTC_2350 9023895 38.85 µM 0.100730749573555 0.471665489150358 no 1570 0.45988210044227 2170 2997209
SGTC_523 1934-0222 13.7 µM 0.0993408369464083 0.472223726645101 no 1571 0.460433827781251 2155 1361595
SGTC_224 benfluorex 43.875 µM 0.0989726985318781 0.472371593086001 no 1572 0.460579973532914 2229 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis.
SGTC_2085 5307070 144.047 µM 0.0989531005526829 0.472379464915409 no 1573 0.460587753803347 2155 2840351
SGTC_2536 dehydroabietamide 32.04 µM 0.0989375832023166 0.472385697705214 no 1574 0.460593914101346 2212 3983547
SGTC_2475 5812728 15.03 µM 0.0969992823023342 0.473164299674811 no 1575 0.461363482201351 2250 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2
SGTC_1002 4049-0206 172 µM 0.0967855461408867 0.473250162332808 no 1576 0.461448351274993 2183 4662749
SGTC_3289 9119912 71.43 µM 0.0954824107913788 0.473773688066339 no 1577 0.461965830289587 2193 17014829
SGTC_3146 9095609 49.47 µM 0.0951137270800295 0.473921812491311 no 1578 0.462112247437596 2174 17173999
SGTC_1589 2',5'-dimethoxyflavone 47.2 µM 0.0949796824591405 0.473975667900913 no 1579 0.462165482500918 2126 688667
SGTC_3042 9091578 49.47 µM 0.0933187002455165 0.474643043621663 no 1580 0.462825188130056 2225 25236497
SGTC_1969 st069479 40.1 µM 0.093173842811165 0.474701250134731 no 1581 0.462882727193405 2227 3895485
SGTC_2290 7904846 200 µM 0.0930666744905535 0.474744312782046 no 1582 0.462925296200832 2157 2962154
SGTC_3257 9139206 32.98 µM 0.0914767591482963 0.475383210998418 no 1583 0.463556886155349 2230 4910041
SGTC_14 0354-0009 295 µM 0.0901622092329699 0.475911503100375 no 1584 0.464079157318343 2222 1713507
SGTC_1565 sinapyl alcohol 95.1 µM 0.0895767893492818 0.47614678567547 no 1585 0.46431176482883 2145 5280507 A phenol propionate derived from cinnamic acid.
SGTC_2866 9034245 58.44 µM 0.0888768489378386 0.476428105414645 no 1586 0.464589891298977 2260 6462273
SGTC_121 0557-0495 61.343 µM 0.0886718277978183 0.476510509651144 no 1587 0.464671361239099 2231 3104427
SGTC_801 0866-0028 10.1 µM 0.0885155952850664 0.47657330492793 no 1588 0.464733444872811 2240 6849771
SGTC_1447 4239-0816 81.9 µM 0.0858255580417638 0.477654614314952 no 1589 0.465802544529021 2092 1341554
SGTC_1084 voriconazole 435 nM 0.0858156745483049 0.4776585874731 no 1590 0.465806472978903 2251 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_117 lucigenin 22.078 µM 0.0854361066464528 0.477811175207161 no 1591 0.465957344567686 2035 65100 An acridine derivative; a dye stuff and potential carcinogen.
SGTC_753 1322-0200 289 µM 0.0842718690601601 0.478279223320261 no 1592 0.466420139030399 2187 5403907
SGTC_107 0358-0022 2.6945 µM 0.0834693191155262 0.478601882840583 no 1593 0.466739186018878 2218 521106 YGL093W | YPR107C SPC105 | YTH1
SGTC_2416 tofa 880 nM 0.0831154527801886 0.478744156761859 no 1594 0.466879869409485 1990 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_2812 7970281 58.44 µM 0.083111527713027 0.478745734872086 no 1595 0.466881429885641 2248 2233435
SGTC_147 4466-0538 29.23 µM 0.0821685324698283 0.479124884592248 no 1596 0.467256348127692 2153 6742687 YHR072W ERG7
SGTC_1287 0971-0001 34.6 µM 0.0791353922002261 0.480344544471106 no 1597 0.468462466434357 2231 4665869
SGTC_717 1532-0246 73.2 µM 0.0789585690111159 0.480415652855443 no 1598 0.468532788635497 2183 9561992
SGTC_1988 st071872 53.4 µM 0.0785694635834015 0.480572131459477 no 1599 0.468687538479684 2281 16414116
SGTC_729 4092-0585 94.1 µM 0.0776891454254157 0.480926162092379 no 1600 0.469037664352305 2200 2169061
SGTC_2929 9013348 24.6 µM 0.0771372983069386 0.481148101798857 no 1601 0.469257160811105 2213 2995952
SGTC_609 0986-0026 86.3 µM 0.0768562269990568 0.48126114420377 no 1602 0.469368960146335 2235 2848610
SGTC_2941 9056145 11.23 µM 0.0767207730709185 0.481315622155626 no 1603 0.469422839362192 2295 2119517
SGTC_2771 fluoxetine 41.05 µM 0.076580232657639 0.481372146199862 no 1604 0.46947874241008 2231 3386 A selective serotonin reuptake inhibitor.
SGTC_1204 4049-0315 18.3 µM 0.0765094539969962 0.481400612859304 no 1605 0.469506896410687 2229 588402
SGTC_1610 st001799 48.1 µM 0.0761074389638708 0.481562302159029 no 1606 0.469666810935785 2144 621897
SGTC_549 1661-1316 519 µM 0.0749056904648295 0.482045659957657 no 1607 0.470144874471757 2268 2857282
SGTC_1451 4152-0210 104 µM 0.0743078401862058 0.482286132454774 no 1608 0.470382719357276 2278 659563
SGTC_792 4534-1957 155 µM 0.0706382661269048 0.483762278094321 no 1609 0.471842827250045 2159 1717904
SGTC_2197 6588183 93.1375 µM 0.0696707046297505 0.48415153329792 no 1610 0.472227879711261 2273 884136
SGTC_2071 5230951 39.92 µM 0.0689647769836831 0.484435541344888 no 1611 0.472508828307047 2266 1799272
SGTC_2971 9092186 9.93 µM 0.0674339041718041 0.485051467375624 no 1612 0.473118139490445 2083 25236400
SGTC_955 1216-0110 33 µM 0.0668744260545429 0.485276574827971 no 1613 0.473340836251152 2250 3619719
SGTC_808 0711-0032 135 µM 0.0667435280043277 0.485329242673445 no 1614 0.473392940605602 2282 4252555
SGTC_1406 3909-7906 11.9 µM 0.0657184283278091 0.485741708254538 no 1615 0.473801000222752 2284 X1406
SGTC_3163 9099914 49.47 µM 0.0653858483387351 0.485875530538564 no 1616 0.473933395678477 2292 16268368
SGTC_958 1222-0007 33 µM 0.0653490415215195 0.485890340825153 no 1617 0.473948048136342 2267 7312461
SGTC_1578 josamycin 24.2 µM 0.0647294156775089 0.486139668095514 no 1618 0.474194720802306 2132 5282165 A P450 substrate.
SGTC_2054 5233173 129 µM 0.0632645820347971 0.486729114481397 no 1619 0.474777909342346 2247 6889
SGTC_1722 st034304 3.6505 µM 0.0631352994640436 0.48678113896323 no 1620 0.474829382724856 2246 4036148 YLR033W RSC58
SGTC_1016 4226-1401 38 µM 0.0629940838139515 0.486837965681714 no 1621 0.474885607699314 2296 2901613
SGTC_2518 prenyletin 46.28 µM 0.0621430598929439 0.487180432610972 no 1622 0.475224453202646 2292 3873459 A coumarin with calcium channel inhibitory activity.
SGTC_3210 9128157 49.47 µM 0.0616733206649914 0.487369467967897 no 1623 0.475411493268949 2071 17590849
SGTC_1662 st014054 52 µM 0.0615386197391224 0.487423675670586 no 1624 0.475465129284546 2300 2838777
SGTC_1742 st038235 28.8875 µM 0.060375452367838 0.487891778754348 no 1625 0.475928304578031 2226 564103 YBR002C RER2
SGTC_2390 9097792 176.6 µM 0.0593981029272827 0.48828511451174 no 1626 0.476317512019118 2168 4497149
SGTC_2247 cerulenin 830 nM 0.0583340615452534 0.488713352514697 no 1627 0.476741268254773 2286 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12
SGTC_1217 1183-1422 255 µM 0.0579233519466895 0.488878651716036 no 1628 0.476904841091946 2274 2849664
SGTC_722 3534-0461 190 µM 0.0571008826286446 0.489209678477904 no 1629 0.477232416668167 2247 658262
SGTC_736 0958-0254 92.6 µM 0.0558759138124255 0.489702716610906 no 1630 0.477720329419401 2255 6812352
SGTC_2244 6635614 200 µM 0.0545776287345454 0.490225280991622 no 1631 0.478237480935965 2179 836499
SGTC_1702 st027038 51 µM 0.0538067080457842 0.490535587319199 no 1632 0.478544582508124 2220 5521182
SGTC_1109 tnp00067 928.257 nM 0.0529820111684947 0.490867545649336 no 1633 0.478873120294086 2200 676295
SGTC_2074 5212007 75.395 µM 0.052758977564277 0.490957322595203 no 1634 0.47896197355647 2327 758611
SGTC_768 0384-0033 77.3 µM 0.0527554546949037 0.490958740647323 no 1635 0.4789633770235 2200 3965305 YMR134W ERG29
SGTC_754 3474-0146 171 µM 0.0526728724614169 0.490991982307479 no 1636 0.478996276825563 2286 24762078
SGTC_918 glabranin 770.725 nM 0.0523238088488812 0.491132490868927 no 1637 0.479135341290246 2260 124049 Also referred to as licorice root.
SGTC_541 4513-1321 94 µM 0.0518351365131139 0.49132919796853 no 1638 0.479330029142051 2179 747515
SGTC_2662 daunorubicin 22.37 µM 0.0508787604094172 0.491714177669613 no 1639 0.479711065161655 2292 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_1103 duloxetine 36.1 µM 0.0508781797747223 0.491714411400723 no 1640 0.479711296501765 2286 60835 A selective serotonin reuptake inhibitor.
SGTC_422 cantharidin 155 µM 0.0503895604508579 0.491911103260156 no 1641 0.479905977686397 2329 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_1284 0929-0043 16 µM 0.0495119624529519 0.492264381919373 no 1642 0.480255652116939 2249 1239883
SGTC_397 arbidol 50 µM 0.0494631415332033 0.492284035049524 no 1643 0.480275105011161 2306 131410 A RNA synthesis inhibitor.
SGTC_1910 st062352 60.4 µM 0.0494118958852919 0.492304664287501 no 1644 0.480295524098723 2314 2245730
SGTC_639 0833-0042 114 µM 0.0492549134224032 0.492367858632177 no 1645 0.480358074876487 2273 5978911 YPR085C | YHR062C ASA1 | RPP1
SGTC_1682 st012968 530 nM 0.0492444939908046 0.492372053051136 no 1646 0.480362226590175 2213 24207270
SGTC_1611 st001856 99.4 µM 0.0489940356222243 0.492472877165498 no 1647 0.480462024558588 2282 647478
SGTC_454 lyso-paf C-16 6.67 µM 0.0487057760543624 0.492588919064124 no 1648 0.480576886357629 2257 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_78 0336-0123 156.75 µM 0.0485063066131431 0.492669217938 no 1649 0.48065636920478 2174 6765896
SGTC_159 3970-0959 50 µM 0.0485029348071919 0.492670575302467 no 1650 0.480657712779292 2305 6615653
SGTC_3330 9141424 71.43 µM 0.0480346921897695 0.492859073293117 no 1651 0.480844297069161 2305 27261020
SGTC_2086 5274770 176.623 µM 0.0478028109432098 0.492952421111269 no 1652 0.480936698155318 2277 689278
SGTC_2983 9022671 12.99 µM 0.0463642673910016 0.493531540197945 no 1653 0.481509958180318 2340 6405161
SGTC_1685 st024049 53.0905 µM 0.0461352982089499 0.493623718344387 no 1654 0.481601206024038 2262 1941139
SGTC_2895 9054447 58.44 µM 0.0458101822267357 0.493754603741332 no 1655 0.481730771544538 2290 2697450
SGTC_860 0443-0016 25.1 µM 0.0451299278082494 0.49402846315223 no 1656 0.482001873388329 2341 5337942
SGTC_589 1227-0070 34.1 µM 0.0450722623895411 0.494051678447016 no 1657 0.482024855176347 2285 2841384
SGTC_517 1365-0151 113 µM 0.0444237692156612 0.494312754139555 no 1658 0.482283307627213 2226 768657
SGTC_491 tetrandrine 80.3 µM 0.0434078449854566 0.49472175809058 no 1659 0.482688212101612 2310 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_56 0957-0365 83.25 µM 0.0432177780567979 0.494798278328568 no 1660 0.482763966744268 2320 6752360
SGTC_3166 9102297 49.47 µM 0.04274313469435 0.494989368809149 no 1661 0.482953147228751 2279 25237072
SGTC_2619 obliquin 87.91 µM 0.0426310198614338 0.495034506189014 no 1662 0.48299783384361 2305 6708593 A bioactive alkalod. YER133W GLC7
SGTC_2952 9073731 13.78 µM 0.0424762099357354 0.495096832697854 no 1663 0.483059538175622 2303 16457353
SGTC_2116 5511452 16.8835 µM 0.0419977319277633 0.495289468795025 no 1664 0.483250253091481 2289 870744
SGTC_344 k064-0035 6.43 µM 0.0417173872721627 0.495402336565278 no 1665 0.483361996494119 2280 5088750
SGTC_1314 1222-0010 41.1 µM 0.0399466340965214 0.496115256319486 no 1666 0.484067836059972 2290 3526027
SGTC_1561 5-methoxyflavone 52.9 µM 0.0387847746334102 0.496583037352939 no 1667 0.484530991891867 2342 94525
SGTC_1413 3910-0535 34.4 µM 0.0387440644179646 0.496599427949736 no 1668 0.4845472207201 2319 2876951
SGTC_2450 5739737 12.93 µM 0.0383854103655563 0.496743828166489 no 1669 0.484690196625668 2286 2262825
SGTC_3193 9111931 49.47 µM 0.0365880436943213 0.49746748457933 no 1670 0.485406738449027 2326 17087244
SGTC_1753 st043925 64 µM 0.0357019052482351 0.497824265172939 no 1671 0.485760025676846 2329 670181
SGTC_922 1866-0035 480 µM 0.0355248864569187 0.497895537402014 no 1672 0.485830601186889 2237 3156169
SGTC_3147 9097027 49.47 µM 0.0350703201619562 0.498078557556926 no 1673 0.486011833963619 2297 25236841
SGTC_361 000s-0510 1.45 µM 0.0349175357434322 0.498140072610732 no 1674 0.48607274881907 2298 660
SGTC_1258 0671-0043 57.1 µM 0.0327645604169405 0.499006921528172 no 1675 0.486931169860029 2320 4298767
SGTC_2749 bexarotene 57.39 µM 0.030298084975666 0.5 no 1676 0.487914661920556 2317 82146 An retinoic acid receptor inhibitor.
SGTC_1905 st060207 84.5 µM 0.027635060246201 0.498927784955047 no 1677 0.488976609151807 2319 1948547
SGTC_1513 0337-0559 19 µM 0.0270436096267156 0.498689649660154 no 1678 0.489212475642845 2328 775073
SGTC_2297 7971671 152.32 µM 0.0269944335205237 0.498669849943288 no 1679 0.489232086911099 2341 909016
SGTC_377 3970-0964 33.1 µM 0.0264040591639226 0.498432148491392 no 1680 0.48946752826768 2340 16481235
SGTC_1852 st056254 31.4 µM 0.0262822220646301 0.498383093487889 no 1681 0.48951611737548 2289 442583
SGTC_499 genistein 192 µM 0.0262106296599157 0.498354268406687 no 1682 0.489544668776805 2363 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger.
SGTC_2743 auranofin 4.32 µM 0.025815333293659 0.498195111321031 no 1683 0.489702315862606 2345 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold.
SGTC_2040 5100729 123 µM 0.0256960797392287 0.498147096646578 no 1684 0.48974987537046 2345 11840 YJR013W | YDR381W GPI14 | YRA1
SGTC_2109 5483026 200 µM 0.0256848878171262 0.498142590480402 no 1685 0.489754338828199 2331 759335
SGTC_2341 7987486 176.74 µM 0.0249928106605738 0.497863942251922 no 1686 0.490030349040334 2351 1258686
SGTC_3313 9133968 57.047 µM 0.0246572487994749 0.497728836702708 no 1687 0.490164177609359 2357 1494643
SGTC_546 peri-Naphthalide 147 µM 0.0242277240546979 0.497555899742304 no 1688 0.490335482009934 2332 223824 A penicillin ester.
SGTC_787 4152-0075 138 µM 0.02214867159041 0.496718830453318 no 1689 0.491164680834839 2313 9566539
SGTC_520 3584-0023 682 µM 0.0215975315606904 0.496496932411152 no 1690 0.491384501301409 2247 1340790
SGTC_487 nimodipine 119 µM 0.0211731522087058 0.496326071038026 no 1691 0.49155376545712 2374 4497 L-type voltage-gated calcium channels inhibitor
SGTC_817 1391-0715 46 µM 0.0205413466409347 0.496071698075537 no 1692 0.491805764588003 2352 1353946
SGTC_1041 0206-0046 107 µM 0.0203583986501493 0.49599804117972 no 1693 0.491878735016927 2272 50494
SGTC_1237 0330-0133 46.1 µM 0.0202964171947842 0.495973086787254 no 1694 0.49190345693195 2375 X1237 YHR072W ERG7
SGTC_1649 st011737 51.3 µM 0.0202430367888007 0.495951595281279 no 1695 0.491924748258493 2343 1761035
SGTC_38 0929-0051 58.268 µM 0.0194194762461233 0.49562002277851 no 1696 0.492253236770032 2370 1379719
SGTC_2336 9001819 198.65 µM 0.0193913665294741 0.495608705618797 no 1697 0.492264448813232 2362 2989602
SGTC_1774 st048371 48.465 µM 0.0193152879040481 0.495578075873702 no 1698 0.492294794110075 2358 4242727
SGTC_260 nsc-65238 3.989 µM 0.0184792636788796 0.495241488887385 no 1699 0.492628259964408 2364 3246252
SGTC_1843 st055809 45.5 µM 0.0182806463655056 0.495161525182893 no 1700 0.492707483425329 2327 16413835
SGTC_2659 sanguinarine 24.21 µM 0.0171140353985415 0.494691849439935 no 1701 0.493172820961843 2376 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis.
SGTC_104 0074-0074 590.992 µM 0.0169871346309334 0.494640759822278 no 1702 0.493223439684889 2380 3943124
SGTC_3213 9129884 49.47 µM 0.0169052134608275 0.494607778813421 no 1703 0.493256116810967 2365 17190742
SGTC_847 0342-0274 5.54 µM 0.0167452329433865 0.494543371650617 no 1704 0.49331993077022 2373 18097
SGTC_1545 lovastatin 49.4 µM 0.0162535586777942 0.494345427542312 no 1705 0.493516053723876 2366 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12
SGTC_1112 tnp00069 1.16933 µM 0.0156543566962042 0.494104195526703 no 1706 0.493755070305024 2371 145826
SGTC_1329 1447-1697 50.6 µM 0.0148201413872006 0.493768353383609 no 1707 0.494087835421189 2324 2840515
SGTC_1882 5615643 20 µM 0.0143035247099797 0.493560373722583 no 1708 0.494293913803894 2381 2253075
SGTC_2917 7979103 53.79 µM 0.0139083327402799 0.493401278426994 no 1709 0.494451556903983 2368 2980565
SGTC_1651 st011928 86.1 µM 0.0129224465374519 0.493004387702987 no 1710 0.494844833186944 2375 720198
SGTC_2523 spermine 47.74 µM 0.0126343744588753 0.492888419081227 no 1711 0.494959747936025 2380 1103 A DNA binding polyamine.
SGTC_505 gw-5074 63.9 µM 0.0117741668798686 0.492542130588906 no 1712 0.495302895542755 2374 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases.
SGTC_1228 0124-0032 52.5 µM 0.0116582289531144 0.492495458592438 no 1713 0.495349144909195 2371 X1228
SGTC_213 1246-0773 967 nM 0.0113989995363742 0.492391103515878 no 1714 0.495452555611235 2350 6251622
SGTC_2912 7964298 10.93 µM 0.0103530301954466 0.491970044741898 no 1715 0.495869812307418 2380 2975850
SGTC_1771 st048882 4.1505 µM 0.0101859235060126 0.491902776151173 no 1716 0.49593647471582 2378 4580403
SGTC_846 0335-0850 148 µM 0.00887478583399192 0.491374987449375 no 1717 0.496459519177162 2383 6819598
SGTC_2412 st077135 33.4 µM 0.00768790263533628 0.49089722945644 no 1718 0.496933000803093 2371 13258915
SGTC_131 0141-0277 33.849 µM 0.00622189598256874 0.490307133553824 no 1719 0.497517838643205 2389 1547771
SGTC_1000 4048-0884 8.67 µM 0.00588263476227399 0.490170577356549 no 1720 0.497653181808605 2384 13040088
SGTC_483 fpl-64176 144 µM 0.00583834390439443 0.490152749906681 no 1721 0.497670851001017 2393 3423
SGTC_136 0097-0015 404.482 µM 0.00579055280129596 0.490133513600183 no 1722 0.497689916570383 2388 4861337
SGTC_1004 4084-0029 199 µM 0.00562812280725586 0.490068134382375 no 1723 0.497754715706417 2394 716894 YLR208W SEC13
SGTC_2487 5918373 44.05 µM 0.00481433218133197 0.48974058197077 no 1724 0.498079366760313 2397 2876279
SGTC_327 1273-0057 3.96 µM 0.00478410337956986 0.489728414947397 no 1725 0.498091426168541 2398 3108138
SGTC_1632 st005650 90 µM 0.00410468206341866 0.489454951969101 no 1726 0.498362473375586 2389 2759605
SGTC_2520 obtusaquinone 4.71 µM 0.00332984797430768 0.489143091983085 no 1727 0.498671585310625 2398 5967872
SGTC_3278 9139605 49.47 µM 0.00224176133138917 0.488705163432672 no 1728 0.499105667371417 2398 7958859
SGTC_2404 5161160 200 µM 0.00114625245518214 0.488264261370894 no 1729 0.499542711531752 2401 2831543
SGTC_2627 acetyl isogambogic acid 100 µM 0.000174188927866927 0.487873053517326 no 1730 0.499930508672247 2403 6857789 A caspase activator and apoptosis inducer.
SGTC_2605 digitonin 300 nM 0 0.487802952246258 no 1731 0.5 2405 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_1192 1488-0095 21.4 µM -0.00015274488025621 0.487741481311326 no 1732 0.499939063609388 2406 915875
SGTC_1913 st060213 96.1 µM -0.000295749479254302 0.48768393053731 no 1733 0.499882013030039 2406 688959
SGTC_3167 9103034 49.47 µM -0.00198690616295582 0.487003361181504 no 1734 0.49920733964595 2408 5127859
SGTC_1658 st012944 20 µM -0.00338715499950515 0.486439889940106 no 1735 0.49864872324425 2418 24207260
SGTC_3109 9122853 49.47 µM -0.00574859897797502 0.485489688052699 no 1736 0.497706653445758 2434 1234709
SGTC_2572 astragaloside iv 100 µM -0.00602347704112331 0.485379087394863 no 1737 0.49759699486436 2444 45006101 An anti-inflammatory agent.
SGTC_247 mechlorethamine 29.705 µM -0.00652440750097481 0.485177534600806 no 1738 0.497397156459567 2416 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links.
SGTC_626 0214-0009 33 µM -0.0075154520585419 0.484778792256147 no 1739 0.497001796641641 2426 3437874
SGTC_1778 st046819 58.9 µM -0.00836673966049201 0.484436292634449 no 1740 0.496662192742746 2419 671715
SGTC_2098 5376439 882.5 nM -0.0088414417676253 0.48424531010359 no 1741 0.496472821013153 2435 2844116
SGTC_1710 st031758 61.5 µM -0.00915237946503964 0.484120215357159 no 1742 0.496348779839904 2423 5394341
SGTC_3052 9092717 49.47 µM -0.0105489435369785 0.48355837682295 no 1743 0.495791658460531 2447 25237534
SGTC_2305 7443522 69.23 µM -0.0113393053879195 0.483240428186715 no 1744 0.495476368591888 2434 5415886
SGTC_2232 chlorophetanol 41.5365 µM -0.0115845864178934 0.483141758110874 no 1745 0.495378522046262 2418 15907 An antifungal of unknown mechanism. YFR051C RET2
SGTC_410 α-linolenic acid 100 µM -0.0121986901830936 0.482894724937942 no 1746 0.495133547415292 2489 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_2339 9000433 200 µM -0.0123733350507297 0.482824472410142 no 1747 0.495063879451878 2440 2988954
SGTC_667 1498-1044 59 µM -0.0125371970398973 0.482758557880691 no 1748 0.494998513046783 2440 6739982
SGTC_1670 st016595 4.04 µM -0.0127724225919469 0.482663937727516 no 1749 0.494904679142635 2431 597879
SGTC_2628 lathosterol 100 µM -0.0128518455514184 0.482631989834441 no 1750 0.494872996566542 2454 6710616
SGTC_2799 7812892 81.82 µM -0.0132767954292422 0.482461055604973 no 1751 0.494703480561316 2433 20205235
SGTC_3149 9097855 49.47 µM -0.0136886213697852 0.48229540349773 no 1752 0.494539200714983 2444 25236625 YMR079W SEC14
SGTC_2851 9015922 71.43 µM -0.0142110841263509 0.482085253443686 no 1753 0.49433078851315 2439 2996893
SGTC_1631 benzylvanillin 81.9 µM -0.0142691491422001 0.482061898274253 no 1754 0.494307626271869 2454 75506
SGTC_2393 9031399 185.94 µM -0.0148032287119378 0.481847081307158 no 1755 0.494094581862348 2436 1526623 YDL150W RPC53
SGTC_281 1672-3440 14.9 µM -0.0168768525254151 0.481013080870454 no 1756 0.493267429573294 2438 6833000
SGTC_1164 k060-0068 93.7 µM -0.0185577640609685 0.480337088028847 no 1757 0.492596948212387 2434 5963676
SGTC_2424 5537928 59.2 µM -0.0188646050601931 0.480213695362357 no 1758 0.49247455779175 2439 5382802
SGTC_1241 0364-0022 50.8 µM -0.0188851938351534 0.480205415885164 no 1759 0.492466345521907 2457 4563895
SGTC_1068 loratadine 26.9 µM -0.0202871467080525 0.479641661150117 no 1760 0.491907154559728 2464 3957 A H1 histamine antagonist.
SGTC_1715 st032160 10.2275 µM -0.0208958609010257 0.479396896983921 no 1761 0.491664364213445 2454 5289825
SGTC_2673 kobusone 100 µM -0.0209958404118623 0.479356695931897 no 1762 0.491624486908033 2444 6710676 An epoxy ketone and protein crosslinker.
SGTC_2287 7945887 168.79 µM -0.0209988093048536 0.479355502164296 no 1763 0.491623302752162 2445 1245853
SGTC_3005 9076496 71.4286 µM -0.0216564010211849 0.479091094493311 no 1764 0.491361021276344 2453 21368410
SGTC_1380 2291-0730 164 µM -0.0221569871250193 0.478889822563424 no 1765 0.491161364230408 2468 2999191
SGTC_782 0083-0095 30.5 µM -0.0222241791499064 0.478862806903473 no 1766 0.491134565089835 2437 3591729 An indicator and reagent.
SGTC_1530 rhein 70.4 µM -0.0228793012339355 0.47859940939091 no 1767 0.490873275648232 2433 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death.
SGTC_2794 7785382 27.27 µM -0.0238093681784787 0.478225483994954 no 1768 0.490502333721466 2431 2205081
SGTC_2439 5492030 7.2 µM -0.0244042290931472 0.47798633532198 no 1769 0.490265087501526 2458 5722370
SGTC_934 2950-0684 338 µM -0.0246574251167751 0.477884546712327 no 1770 0.490164107290312 2443 1121253
SGTC_2008 4012253 172 µM -0.0248447762961482 0.477809229648699 no 1771 0.490089387874384 2467 603940
SGTC_1028 k015-0029 4.8 µM -0.0256275447667564 0.477494557432985 no 1772 0.489777207867562 2449 4588309
SGTC_2266 7929956 200 µM -0.0259477109796938 0.477365854937571 no 1773 0.489649522491569 2439 2967153
SGTC_3240 9133527 49.47 µM -0.0274290022405509 0.476770426786058 no 1774 0.48905878325192 2451 17617455
SGTC_1183 1254-0324 198 µM -0.0275760184379277 0.476711334137144 no 1775 0.489000154452192 2482 5799357
SGTC_3329 9141233 27.5565 µM -0.0280103829316361 0.476536745837218 no 1776 0.488826935007549 2483 4909101 YNL103W MET4
SGTC_1581 himbacine 57.9 µM -0.0293910001407478 0.475981851149463 no 1777 0.488276375276395 2456 5281825 An alkaloid muscarinic receptor antagonist.
SGTC_1306 1185-0270 9.02 µM -0.0311775989953254 0.475263854484098 no 1778 0.487563952320179 2478 1548076
SGTC_732 3970-1727 52.7 µM -0.0312077494543362 0.475251738328655 no 1779 0.487551929877545 2469 1275699
SGTC_3134 9127454 49.47 µM -0.0318617549331518 0.474988927681227 no 1780 0.487291149142793 2452 24262820
SGTC_1134 3477-0009 42.5 µM -0.0327672263102497 0.47462508400892 no 1781 0.486930106893229 2489 3973534
SGTC_113 0099-0221 2.5 µM -0.0329917915312787 0.474534850698483 no 1782 0.486840566744355 2456 89219
SGTC_2430 5571206 200 µM -0.0330758574497562 0.474501072223441 no 1783 0.486807047588747 2471 1731771
SGTC_1501 4491-0275 38.4 µM -0.0333383584896726 0.474395598022822 no 1784 0.486702382549186 2458 5104718
SGTC_2685 mycophenolic acid 18.85 µM -0.0346909914824107 0.473852132087322 no 1785 0.486163072180407 2500 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_1038 k292-0204 154 µM -0.0363767090782478 0.473174906400194 no 1786 0.485490992674213 2465 4454212
SGTC_1820 st053765 18.6 µM -0.0371327225994236 0.472871208126197 no 1787 0.485189590575429 2500 3690829
SGTC_318 1488-0629 67.2 µM -0.037142362633996 0.472867335728305 no 1788 0.485185747409209 2527 3662576
SGTC_2222 6885208 172.143 µM -0.0374189506409235 0.472756231534265 no 1789 0.485075481412428 2471 609514
SGTC_135 0933-0004 26.348 µM -0.0382449637616334 0.472424438323411 no 1790 0.484746185601571 2493 21230617 YGL099W LSG1
SGTC_2396 5342950 42.78 µM -0.038352545810041 0.472381226135675 no 1791 0.484703298039029 2494 1886677
SGTC_157 1348-1695 65.819 µM -0.0395637674727987 0.471894740588565 no 1792 0.484220457088396 2482 5380510
SGTC_3001 9076041 71.4286 µM -0.0397105115847739 0.471835803847149 no 1793 0.484161960627813 2488 16004211
SGTC_2938 9059746 27.26 µM -0.0399807999809012 0.47172724971101 no 1794 0.484054216724202 2514 6471769
SGTC_3243 9134147 49.47 µM -0.0405103864510211 0.471514561505618 no 1795 0.483843113324762 2474 24282180
SGTC_1772 st048439 82.2 µM -0.0479853022777368 0.468513441399011 no 1796 0.480863978098229 2527 2927068 YDL195W SEC31
SGTC_3309 9129340 25.759 µM -0.048402890527895 0.468345834155516 no 1797 0.480697577849415 2543 17158987
SGTC_109 0132-0036 33.701 µM -0.0486716572660324 0.468237962313708 no 1798 0.480590481660843 2484 67274 A color developer.
SGTC_568 1193-0097 7.48 µM -0.0490737446446789 0.468076585442808 no 1799 0.480430263464324 2499 3646150
SGTC_1617 st002906 78 µM -0.0496064118200672 0.467862808744577 no 1800 0.480218018515633 2502 5150859
SGTC_3150 9097574 49.47 µM -0.0499261834621859 0.467734478410414 no 1801 0.480090605966129 2507 17217476
SGTC_573 3702-0553 84.7 µM -0.0502678207739964 0.467597376679838 no 1802 0.479954483319922 2497 1222756
SGTC_2795 7780010 54.55 µM -0.0505459578433816 0.467485760931885 no 1803 0.479843663561463 2554 953673
SGTC_1755 st041960 45.185 µM -0.0506578236824502 0.467440870155659 no 1804 0.47979909264815 2536 2257073
SGTC_536 3852-0578 10.6 µM -0.0507559324889091 0.467401500296303 no 1805 0.479760003182678 2495 2869208
SGTC_1210 3013-0140 750 nM -0.051059088251753 0.467279849627873 no 1806 0.479639218144959 2532 905973
SGTC_212 3807-4682 38.772 µM -0.0531446218189541 0.466443047918974 no 1807 0.478808339297107 2557 3125501 YBL034C STU1
SGTC_275 trichlorophene 5.69 µM -0.0547583097848674 0.465795671627957 no 1808 0.478165507256015 2580 62616
SGTC_372 0155-0182 15.9 µM -0.05606901278939 0.465269912799802 no 1809 0.477643414651501 2510 771486
SGTC_1127 asiatic acid 681.4 nM -0.0567698674291896 0.464988805647585 no 1810 0.477364258760715 2510 470603 A kinase inhibitor which arrests cells at G2/M.
SGTC_171 k064-0041 9.68 µM -0.0573294502999894 0.464764374001636 no 1811 0.477141380489238 2515 53325
SGTC_2678 equilin 100 µM -0.0577744817055881 0.464585893458057 no 1812 0.47696413243316 2506 3247 Equilin is an estrone commonly used hormone replacement therapy
SGTC_2620 irigenin 100 µM -0.0603622151521189 0.463548221208179 no 1813 0.475933575849 2565 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro.
SGTC_1340 1486-1359 257 µM -0.0604856589512502 0.463498726807615 no 1814 0.475884418717888 2571 4309068
SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM -0.0618335773481938 0.462958320121836 no 1815 0.475347681890421 2506 5355888
SGTC_702 1488-0190 94 µM -0.0619700574121944 0.462903606405616 no 1816 0.475293338439873 2515 949357
SGTC_1398 3558-0053 112 µM -0.0621653410029735 0.462825320068057 no 1817 0.475215581478738 2524 4532369
SGTC_3284 9108171 64.8615 µM -0.0627519943211897 0.462590147998294 no 1818 0.474981996731143 2571 8687505
SGTC_1086 cerivastatin 2.18 µM -0.0629912498513587 0.462494241238644 no 1819 0.474886736045908 2515 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7
SGTC_1054 3429-0080 167 µM -0.0631415953940674 0.462433975601309 no 1820 0.474826876013614 2542 1162877
SGTC_855 0428-0020 25 µM -0.0636027144849546 0.4622491425435 no 1821 0.474643285137196 2549 6812414
SGTC_237 nikkomycin 200 µM -0.0643907997986994 0.461933268598141 no 1822 0.474329527761385 2532 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine.
SGTC_307 1501-1223 22.3 µM -0.0647207050543699 0.461801045774312 no 1823 0.474198188566741 2550 2830329
SGTC_1212 0520-0165 585 µM -0.0648667328922775 0.461742520581546 no 1824 0.47414005404723 2668 5403258
SGTC_1900 st060200 72.8 µM -0.0651206730390071 0.461640748152074 no 1825 0.474038960331023 2511 688945
SGTC_381 3461-2219 42.7 µM -0.0651295931111454 0.461637173270993 no 1826 0.474035409275608 2551 2883159
SGTC_1625 st003711 30.1 µM -0.0653509440874786 0.461548463836463 no 1827 0.473947290741342 2576 24207034 YER133W GLC7
SGTC_490 phenamil 164 µM -0.0657164706691821 0.461401978243985 no 1828 0.473801779530899 2598 4755 Irreversibly blocks amiloride-sensitive Na+ channels.
SGTC_2861 9024595 19.48 µM -0.0658724656823426 0.461339464487791 no 1829 0.473739681079614 2502 16482810
SGTC_2437 5741531 144.16 µM -0.0676566415959662 0.460624538556649 no 1830 0.473029482588078 2571 2262990
SGTC_402 epigallocatechin gallate 10 µM -0.0676875699281293 0.460612146574277 no 1831 0.473017172188835 2540 65064 An antioxidant.
SGTC_3195 9113082 49.47 µM -0.0686952594232802 0.460208418980787 no 1832 0.472616095861844 2508 17018038
SGTC_652 0437-0092 114 µM -0.0701081924968649 0.459642401009891 no 1833 0.472053773040026 2532 3091274
SGTC_3038 9091290 49.47 µM -0.0710374550128897 0.459270184942716 no 1834 0.47168397299256 2564 25236843
SGTC_2132 5317594 122.667 µM -0.0712561947465958 0.459182573929065 no 1835 0.471596929046176 2538 794577
SGTC_770 0389-1121 67.2 µM -0.0725381787948257 0.458669145608159 no 1836 0.471086811597635 2712 6753108
SGTC_997 3996-0078 137 µM -0.0736779402733127 0.458212734594516 no 1837 0.470633326091572 2581 735687
SGTC_2295 7971645 200 µM -0.07595165290958 0.457302404436807 no 1838 0.469728781211056 2615 2978226 YKL099C UTP11
SGTC_2307 7538926 6.34 µM -0.0774608488846576 0.456698288481779 no 1839 0.469128467860901 2586 96582
SGTC_2808 7946468 45.46 µM -0.0777973500965591 0.456563604028264 no 1840 0.468994627189364 2596 2970879
SGTC_2121 5257820 149.641 µM -0.0785171975950946 0.456275502176349 no 1841 0.468708325375507 2564 791256
SGTC_2342 7990637 118.86 µM -0.0812107002985271 0.455197696867309 no 1842 0.46763719500907 2617 2033102 YER133W GLC7
SGTC_118 0083-0097 135.343 µM -0.0827179375926591 0.454594719106267 no 1843 0.467037910807597 2578 5207356
SGTC_1495 4469-0029 237 µM -0.0827234349531318 0.454592520050556 no 1844 0.467035725168729 2548 793680
SGTC_1246 0422-0085 105 µM -0.0837861298234181 0.454167446762241 no 1845 0.466613238018793 2576 264295
SGTC_1185 1319-0113 81.3 µM -0.083787202050757 0.454167017902432 no 1846 0.466612811760812 2629 4672763
SGTC_690 glyoxal 20.3 µM -0.0839562366788562 0.454099409626838 no 1847 0.466545613469057 2556 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins.
SGTC_1378 2093-0007 380 nM -0.0845505661782154 0.453861708002946 no 1848 0.466309350369512 2625 3618014
SGTC_677 0929-0063 136 µM -0.0846357130602783 0.453827654924695 no 1849 0.466275503001012 2560 1539583
SGTC_1952 st077036 64.1 µM -0.0850690160338757 0.453654367876681 no 1850 0.466103261306939 2554 2937007
SGTC_1740 st038286 13.222 µM -0.0856020607497835 0.453441204097559 no 1851 0.465891380116866 2659 716786
SGTC_2773 thioridazine 9.09 µM -0.0882219662857854 0.45239370395195 no 1852 0.464850129407175 2536 5452 An antipsychotic.
SGTC_1954 st077032 68.9 µM -0.0888599395314985 0.45213867704906 no 1853 0.464596610590537 2654 698907
SGTC_1671 st016596 74.5 µM -0.0896559484525516 0.451820503805462 no 1854 0.464280311472018 2603 2829167
SGTC_2385 9074692 200 µM -0.0898655186457521 0.45173674150472 no 1855 0.464197041191863 2583 17046906
SGTC_1752 st044819 83.042 µM -0.0913129962164326 0.451158263653522 no 1856 0.463621945822074 2598 441209 YML126C ERG13
SGTC_114 0364-0001 490.298 µM -0.0923192732834441 0.450756170622699 no 1857 0.463222187947238 2610 4003655
SGTC_1291 0993-0025 5.79 µM -0.0925076211081235 0.450680915294861 no 1858 0.463147368209218 2645 4353356
SGTC_2695 st077686 51.995 µM -0.0927292859606045 0.450592350251091 no 1859 0.463059315205912 2607 2876092
SGTC_560 2332-1943 155 µM -0.0928217065031054 0.450555424828423 no 1860 0.463022603080417 2556 21177716
SGTC_1419 3993-2473 62.6 µM -0.0934664063313966 0.450297855341274 no 1861 0.462766518349981 2586 704026
SGTC_2910 7948405 25.97 µM -0.0943675863393599 0.449937852390336 no 1862 0.462408581613634 2619 2971328
SGTC_440 fluspirilene 35.1 µM -0.0948531404855704 0.449743900514677 no 1863 0.462215738552217 2824 3396 An atypical antipsychotic.
SGTC_1139 k015-0024 46.9 µM -0.0958822137123452 0.449332882734599 no 1864 0.4618070604449 2558 2766652
SGTC_1351 1496-0003 46.5 µM -0.0960069951490006 0.449283047995904 no 1865 0.461757508451863 2638 3891978
SGTC_2601 securinine 100 µM -0.0960232001386573 0.449276576167041 no 1866 0.461751073327186 2606 442872 A GABA receptor antagonist.
SGTC_1174 0739-0097 51.1 µM -0.0972060572520934 0.448804211996981 no 1867 0.461281378918358 2611 728447
SGTC_765 1319-0117 244 µM -0.0994471789876099 0.447909438149387 no 1868 0.460391612486727 2595 3487746 YGL099W LSG1
SGTC_2083 5306046 65.942 µM -0.100273662701348 0.447579528953491 no 1869 0.460063533104278 2614 539837
SGTC_623 k072-0108 16.9 µM -0.100461878980223 0.447504403337302 no 1870 0.459988822925737 2664 5382803
SGTC_287 k060-0039 29.6 µM -0.100716389003917 0.447402819889478 no 1871 0.459887800493026 2656 5861974
SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM -0.100985134888083 0.447295558179564 no 1872 0.459781130244092 2606 279621
SGTC_1689 st020265 53.493 µM -0.101858208538575 0.446947124145218 no 1873 0.459434611062675 2608 5758320 YPR016C TIF6
SGTC_417 st075190 100 µM -0.101989137089355 0.446894875533422 no 1874 0.459382648733918 2584 222757
SGTC_386 1509-0011 3.07 µM -0.102211258911002 0.446806237259696 no 1875 0.459294495621443 2591 3107280
SGTC_2505 galangin 7.89 µM -0.102762501791446 0.446586273886373 no 1876 0.45907573344546 2566 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_2517 totarol 10 µM -0.10423937157748 0.445997037228604 no 1877 0.458489695071227 2640 460178 An antibacterial membrane disruptor. YGL001C ERG26
SGTC_2107 5363541 170.161 µM -0.105026055223388 0.445683217363576 no 1878 0.458177566986407 2593 244052
SGTC_975 1335-0046 28.5 µM -0.105681545887474 0.445421758320179 no 1879 0.457917511296998 2631 16486740
SGTC_2904 7225135 42.03 µM -0.106261086207374 0.445190613760908 no 1880 0.45768760272187 2675 4446116
SGTC_2072 5231554 129 µM -0.106705361519571 0.445013431072735 no 1881 0.457511364508852 2662 789545
SGTC_254 nsc-64875 3.808 µM -0.106743340280416 0.444998285165339 no 1882 0.457496299217658 2752 56993
SGTC_2623 humulene 100 µM -0.107115919309454 0.444849705129569 no 1883 0.457348509023345 2647 6187145 An anti-inflammatory.
SGTC_2061 5245884 80.95 µM -0.108455764902356 0.44431545500007 no 1884 0.456817083981705 2615 573863
SGTC_1856 st057054 55.7 µM -0.109152779964521 0.444037567102899 no 1885 0.456540656287645 2796 1266018
SGTC_758 0868-0029 16 µM -0.109452980243177 0.443917890891753 no 1886 0.456421606980777 2696 762687
SGTC_1400 3771-8998 51.5 µM -0.109559176551424 0.443875556472776 no 1887 0.45637949404226 2638 670767
SGTC_2374 9071832 200 µM -0.110263249332886 0.443594898981186 no 1888 0.456100301141749 2587 17381698
SGTC_3119 9125183 49.47 µM -0.111948317458841 0.442923312263248 no 1889 0.455432192782253 2579 22695334
SGTC_1264 0783-0040 158 µM -0.112287589432957 0.442788114617212 no 1890 0.455297690883835 2594 2855798
SGTC_1012 4112-3522 18 µM -0.112537741015818 0.442688435125552 no 1891 0.455198523395092 2601 3112398
SGTC_2174 5790901 200 µM -0.114047209808978 0.442087024710895 no 1892 0.454600184770293 2672 786020
SGTC_324 1315-0088 19.6 µM -0.115856022290647 0.441366524125547 no 1893 0.453883325018896 2628 6787421
SGTC_594 1487-1584 10.8 µM -0.11595614143323 0.441326649516002 no 1894 0.453843650653981 2642 5013332
SGTC_2726 cimetidine 79.27 µM -0.116815543467387 0.440984398610076 no 1895 0.453503113088979 2610 2756 A P450 inhibitor, histamine H2-receptor antagonist.
SGTC_2596 sinensetin 100 µM -0.120443079513605 0.439540246112771 no 1896 0.452066083622981 2673 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets.
SGTC_2957 9076800 11.52 µM -0.12153058827774 0.439107455574541 no 1897 0.451635394157302 2668 16459615
SGTC_1067 clotrimazole 1.36 µM -0.122667039192762 0.438655265544885 no 1898 0.451185382806528 2642 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_3131 9127911 49.47 µM -0.123796644879269 0.438205878546572 no 1899 0.450738144189157 2833 45595681
SGTC_1047 2043-3044 82 µM -0.124048248005014 0.438105795001831 no 1900 0.450638536832283 2625 669592
SGTC_1364 1653-0028 37.6 µM -0.124440500021489 0.437949771563441 no 1901 0.450483254080421 2701 5718652
SGTC_3279 9140807 49.47 µM -0.125043984412185 0.437709746492753 no 1902 0.450244364529774 2625 45595718
SGTC_1917 st066507 28.5 µM -0.125162032032903 0.437662797850427 no 1903 0.450197637434578 2624 3156428
SGTC_253 dyclonine 31.25 µM -0.125365953981668 0.437581698252811 no 1904 0.450116920108657 2612 3180 An oral anasthetic.
SGTC_2960 9079389 5.97 µM -0.125469430265286 0.437540546819374 no 1905 0.450075962438005 2698 16457355
SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM -0.128939970528466 0.436160743404025 no 1906 0.448702574365616 2715 5379071
SGTC_2700 st077718 96.8 µM -0.129401961079983 0.435977125264331 no 1907 0.448519798005714 2706 904970
SGTC_1911 st060208 74.3 µM -0.130883541216419 0.435388364529059 no 1908 0.447933717438985 2744 688783
SGTC_408 cantharidin 100 µM -0.133398492386013 0.434389284059857 no 1909 0.446939118827354 2690 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_175 3793-3120 23.7 µM -0.133505365945536 0.43434683708725 no 1910 0.446896860424986 2664 5322297
SGTC_195 4234-0266 16.654 µM -0.13447362615205 0.433962307722721 no 1911 0.446514032465835 2680 2303354
SGTC_1322 1348-1070 12 µM -0.135122145155355 0.433704793483424 no 1912 0.446257650721799 2642 6758089
SGTC_2810 7959871 45.46 µM -0.135147885938629 0.433694572900625 no 1913 0.446247474972574 2750 2974535
SGTC_3086 9117350 49.47 µM -0.135564404128612 0.43352919720696 no 1914 0.446082823500274 2640 2679265
SGTC_1783 st039459 87.517 µM -0.135869187385848 0.433408192474185 no 1915 0.445962347227073 2875 729761
SGTC_2657 nystatin 74.44 µM -0.13849971854763 0.432364082318354 no 1916 0.444922746019576 2699 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_2468 5987765 72.9 µM -0.138784793586748 0.432250958590491 no 1917 0.444810105324107 2714 26772094
SGTC_280 3448-3607 3.04 µM -0.138884610971214 0.432211350280476 no 1918 0.444770665885707 2653 626179
SGTC_3285 9112818 20.8695 µM -0.140151356365675 0.431708755230199 no 1919 0.444270202232081 2637 17017947 YPR165W RHO1
SGTC_2588 indole-3-carbinol 100 µM -0.14074867445705 0.431471801059307 no 1920 0.444034245573831 2768 3712 Induces cell cycle arrest.
SGTC_1211 1056-0033 32.3 µM -0.140925969463223 0.43140147344094 no 1921 0.443964213107686 2673 6741922
SGTC_236 1509-0011 5.31 µM -0.142670460956004 0.430709602226995 no 1922 0.443275223381542 2723 3107280
SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM -0.142994065151104 0.430581283026862 no 1923 0.44314743417484 2731 16725076
SGTC_2465 5809242 33.21 µM -0.143051629256584 0.430558457823336 no 1924 0.443124703100456 2645 2731748
SGTC_353 1988-1175 58.3 µM -0.143114369967285 0.430533580266933 no 1925 0.443099928086968 2602 2788357
SGTC_2268 7933382 153.85 µM -0.144567637958792 0.429957416833252 no 1926 0.442526124961728 2627 935025 YOR257W CDC31
SGTC_3345 9148410 3.559 µM -0.145431355091174 0.429615057632381 no 1927 0.442185155018119 2738 4903596
SGTC_102 gallobenzophenone 83.616 µM -0.145743126360126 0.429491491083059 no 1928 0.442062087461288 2800 70837
SGTC_2490 carminic acid 95.39 µM -0.146156898217342 0.42932750857631 no 1929 0.441898765167814 2619 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_1895 st058434 18.3 µM -0.146567431707193 0.429164821523311 no 1930 0.441736730870135 2781 5393175
SGTC_853 0419-0306 21 µM -0.147012829249703 0.428988332080542 no 1931 0.441560947036035 2662 762713
SGTC_3066 9117245 49.47 µM -0.147369324181606 0.42884708065737 no 1932 0.441420258444309 2723 17176980
SGTC_2151 5563267 85.4165 µM -0.148694215412708 0.428322208536024 no 1933 0.440897462963168 2716 5310824
SGTC_777 1315-0167 517 µM -0.148747529609982 0.428301090101571 no 1934 0.440876427595857 2758 4221767
SGTC_1249 0481-0015 10.2 µM -0.149384621143113 0.428048745912591 no 1935 0.440625073058436 2673 4227577
SGTC_883 0850-0245 24.6 µM -0.150409090790628 0.427643027713525 no 1936 0.440220934724155 2880 6823229 YPR165W RHO1
SGTC_1657 st012939 43.4 µM -0.150517278791409 0.427600186743746 no 1937 0.440178259763655 2798 24207257
SGTC_3070 9117005 49.47 µM -0.151380477543714 0.427258402451552 no 1938 0.439837794323512 2665 8779016
SGTC_2953 9074162 66.49 µM -0.152391427123068 0.426858185517601 no 1939 0.439439109136827 2751 16451992
SGTC_907 3448-6986 75.5 µM -0.15245515000977 0.426832961279589 no 1940 0.439413980984504 2785 590582
SGTC_76 0433-0009 400.328 µM -0.152895703905108 0.42665857943703 no 1941 0.439240261931884 2827 2841569
SGTC_300 r073-0011 5.04 µM -0.154442660842807 0.42604637038273 no 1942 0.438630359330344 2698 2735780
SGTC_2940 9060638 45.86 µM -0.154893558677893 0.425867960791071 no 1943 0.438452615895978 2779 4027022
SGTC_2056 5235370 200 µM -0.1550239382124 0.425816375524494 no 1944 0.438401222737891 2733 5511916
SGTC_3347 9188721 44.724 µM -0.155429041512916 0.425656102632124 no 1945 0.438241545274616 2763 44118411 YKL104C | YBL026W GFA1 | LSM2
SGTC_2113 5491891 107.031 µM -0.155471361612065 0.425639360043694 no 1946 0.438224864760571 2694 789979
SGTC_466 geldanamycin 89.2 µM -0.156284672839202 0.425317625651844 no 1947 0.437904318594056 2670 5288382 HSP90 inhibitor.
SGTC_456 gingerol 170 µM -0.156694010534385 0.425155716260992 no 1948 0.437743003835433 2839 442793 A herb.
SGTC_2460 5552655 174.22 µM -0.156811631094685 0.425109194969852 no 1949 0.437696652987059 2789 5401989
SGTC_941 3237-0776 460 µM -0.156885888816264 0.425079825088294 no 1950 0.43766739061483 2837 760008
SGTC_1219 1469-0211 33.1 µM -0.157159209107936 0.424971726989565 no 1951 0.437559687580209 2731 6822282
SGTC_3276 9139060 49.47 µM -0.157647085121996 0.424778786189868 no 1952 0.437367449446013 2668 4870619
SGTC_863 0466-0191 129 µM -0.15860977806907 0.424398121979444 no 1953 0.436988162269711 2715 765160 YPR165W RHO1
SGTC_2539 epi(13)torulosol 80 µM -0.158680590995878 0.424370124193676 no 1954 0.436960265277265 2777 6708597
SGTC_3135 9127742 49.47 µM -0.158972654212727 0.424254653218898 no 1955 0.436845209297533 2768 3643468
SGTC_2279 7948423 32.93 µM -0.159919963272661 0.423880167107852 no 1956 0.436472061245043 2681 1247112
SGTC_208 k072-0098 12.366 µM -0.161534984078119 0.423241882727587 no 1957 0.435836029917838 2694 5948901
SGTC_1705 st027868 56.3335 µM -0.163024702698712 0.422653298478219 no 1958 0.435249492456448 2773 292948
SGTC_3080 9117754 49.47 µM -0.165180423649165 0.421801884299516 no 1959 0.434400986633641 2880 9550191
SGTC_119 0121-0043 24.815 µM -0.165825779954911 0.421547068064476 no 1960 0.434147028763456 2683 1092378
SGTC_3017 9080681 49.47 µM -0.166189017609855 0.421403659638534 no 1961 0.434004100971684 2774 16451914
SGTC_430 0958-0115 16.4 µM -0.166497930319089 0.421281707232347 no 1962 0.433882555902977 2729 6833180
SGTC_404 fumagillin 50 µM -0.166841423576216 0.421146112001722 no 1963 0.43374741208186 2737 12015870 A methionine aminopeptidase binder.
SGTC_389 tpck 16.7 µM -0.168513737039277 0.420486093983002 no 1964 0.433089568804892 2763 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.
SGTC_2679 rapamycin 1 nM -0.16900772149232 0.420291174023067 no 1965 0.432895283949251 2752 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2
SGTC_3293 9120939 62.045 µM -0.169459958916309 0.420112744044979 no 1966 0.432717432485536 2851 934087
SGTC_3013 9080133 71.4286 µM -0.170591699560133 0.419666288549355 no 1967 0.43227241252204 2898 17050193
SGTC_2694 st077685 81.9 µM -0.172032062143935 0.419098235693938 no 1968 0.43170616140029 2695 2838096
SGTC_3088 9117578 49.47 µM -0.172253819526307 0.419010793555948 no 1969 0.43161899414211 2720 678341
SGTC_1450 4112-4260 37.6 µM -0.172963062211763 0.418731155802697 no 1970 0.43134023102736 2697 1633175
SGTC_357 1325-0123 420 µM -0.173127986624837 0.418666135854361 no 1971 0.431275413480259 2814 1098503
SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM -0.173564056226295 0.418494230092767 no 1972 0.431104041090857 2692 91467 include heat shock
SGTC_873 0591-4978 488 µM -0.173868790281142 0.418374108186884 no 1973 0.430984290375491 2930 3305145
SGTC_2363 9053361 176 µM -0.175886637088885 0.417578893774321 no 1974 0.430191501873337 2862 6469797 YMR079W SEC14
SGTC_3306 9127676 59.7925 µM -0.177116113430951 0.417094533716918 no 1975 0.429708592666898 2784 41905287
SGTC_916 4466-0038 42 nM -0.178176585803282 0.416676854872662 no 1976 0.42929214865358 2811 5722064 YGL116W CDC20
SGTC_382 3229-0966 23.2 µM -0.178421870383559 0.4165802601866 no 1977 0.42919583739287 2889 5722370
SGTC_2419 paclitaxel 166.5 µM -0.180343427425338 0.415823713084346 no 1978 0.4284414821917 2664 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_3192 9110362 49.47 µM -0.180706744392021 0.415680704476804 no 1979 0.428298882342873 2682 16649480
SGTC_2281 7943571 200 µM -0.181075162662794 0.415535699299875 no 1980 0.428154289821225 2853 1244024
SGTC_1242 0402-0103 60.1 µM -0.181417578278869 0.415400938779589 no 1981 0.428019911167424 2718 432868
SGTC_2874 9043904 71.43 µM -0.181738691447898 0.415274571055884 no 1982 0.427893900096748 2815 4463428
SGTC_961 1252-1571 372 µM -0.183231751174416 0.414687122297993 no 1983 0.427308091124732 2862 6813498
SGTC_1875 nocodazole 6 µM -0.183958579598124 0.414401218455156 no 1984 0.42702297450263 2731 4122 A microtubule depolymerizer. YJL014W CCT3
SGTC_1411 3909-8223 150 µM -0.18410373732285 0.414344124917187 no 1985 0.426966037317764 2805 X1411
SGTC_866 0495-0101 262 µM -0.184934924472469 0.414017236693261 no 1986 0.426640038835122 2736 635694
SGTC_3179 9107801 49.47 µM -0.185400126406027 0.413834308651357 no 1987 0.42645760464081 2760 4818259
SGTC_1304 1165-0502 251 µM -0.185460525399412 0.413810559755936 no 1988 0.426433919646344 2777 767425
SGTC_3220 9131269 49.47 µM -0.18556354585331 0.413770052821762 no 1989 0.426393521590597 2679 17722206
SGTC_191 3914-0123 66.505 µM -0.187182149576015 0.413133749688439 no 1990 0.425758910028012 2744 3144412
SGTC_115 0527-0192 112.043 µM -0.187969706788357 0.412824228743138 no 1991 0.425450199172512 2821 4233931
SGTC_2709 st078560 56 µM -0.188902963310172 0.412457516111308 no 1992 0.425084435503534 2856 17250903
SGTC_1927 st060202 13.8 µM -0.189174265248685 0.412350925392596 no 1993 0.424978118415014 2704 688887
SGTC_262 fenpropimorph 62.5 µM -0.189964317368573 0.412040561868337 no 1994 0.424668545980655 2738 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_1881 5652484 16 µM -0.19026578679139 0.411922147319776 no 1995 0.424550431043887 2862 2255129
SGTC_1831 st055328 12 µM -0.191847038926804 0.411301176924242 no 1996 0.423931011764537 2892 1103068
SGTC_2964 9083345 53.42 µM -0.192671688043306 0.410977418640637 no 1997 0.423608048821043 2792 17741579
SGTC_1381 2324-0066 62.1 µM -0.192736069009117 0.410952145140974 no 1998 0.42358283702198 2860 10885928
SGTC_313 3474-0040 5.03 µM -0.192977366220728 0.410857424393615 no 1999 0.42348834702049 2737 1043375 YIL048W NEO1
SGTC_271 rotenone 740 µM -0.193496896915027 0.410653501288517 no 2000 0.423284918019491 2874 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria.
SGTC_3268 9137683 49.47 µM -0.194541915396113 0.410243390030447 no 2001 0.422875789429529 2721 1953228
SGTC_2317 5986382 200 µM -0.195139799768949 0.410008797989394 no 2002 0.422641752867446 2809 877883
SGTC_3140 9094243 49.47 µM -0.195635038533784 0.409814505413776 no 2003 0.422447916694168 2701 19291112
SGTC_2715 st079500 56.4 µM -0.19578954077805 0.409753895465537 no 2004 0.422387448443926 2729 28246688
SGTC_852 0418-0143 439 µM -0.196933193487558 0.409305317151198 no 2005 0.421939908823351 2850 5369229
SGTC_2409 alverine citrate 63.97 µM -0.199590806236724 0.408263373237404 no 2006 0.42090030933576 3022 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_1270 0831-1170 17.3 µM -0.200296436630592 0.407986832326535 no 2007 0.420624374620182 2739 6764716
SGTC_764 1951-2361 146 µM -0.201178762526786 0.40764110785251 no 2008 0.420279398523966 2776 5438930
SGTC_494 Boc-Gly-Val-Val-CHO 140 µM -0.201235878715276 0.407618730315954 no 2009 0.420257069064444 2757 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA.
SGTC_3126 9127922 49.47 µM -0.201304398285446 0.407591885449178 no 2010 0.420230281814321 3023 45595682
SGTC_87 0100-0052 35.5 µM -0.201482044223134 0.407522288645948 no 2011 0.420160834089687 2797 200187 YGR083C | YDR527W GCD2 | RBA50
SGTC_2532 xanthone 78.9 µM -0.201656660575939 0.407453881595492 no 2012 0.420092573153298 2871 7020 An insecticide.
SGTC_1182 1222-0449 220 µM -0.201804304536605 0.407396043350497 no 2013 0.420034858126092 2825 658318
SGTC_2112 5488546 200 µM -0.202341855945712 0.407185479298641 no 2014 0.419824740165389 2761 600757
SGTC_2062 5245942 200 µM -0.202882157422055 0.406973865045066 no 2015 0.419613570287971 2732 1376160
SGTC_3071 9117417 49.47 µM -0.202961315068966 0.406942864472841 no 2016 0.419582634483137 2844 45595590 YGL055W OLE1
SGTC_3107 9121808 49.47 µM -0.205219221168713 0.406058845133327 no 2017 0.418700426353592 2758 662681
SGTC_3168 9103419 49.47 µM -0.210714086810753 0.403909494419729 no 2018 0.416555190856591 2777 16649256
SGTC_912 3474-0017 2.18 µM -0.21108678495313 0.403763815458681 no 2019 0.416409775992828 2943 3360550
SGTC_3025 9087895 49.47 µM -0.211345504857566 0.403662695765445 no 2020 0.416308838508248 2901 17173641
SGTC_2103 5378138 10 µM -0.211522272250213 0.403593610602795 no 2021 0.416239877308537 2776 244142
SGTC_2138 5575593 77.673 µM -0.211645274355767 0.40354554004719 no 2022 0.416191892758101 2784 762213
SGTC_3133 9127736 49.47 µM -0.212243624938637 0.403311718953533 no 2023 0.415958487074981 2778 27243420
SGTC_2167 5876490 200 µM -0.213482213818104 0.402827817957336 no 2024 0.415475430342792 3018 686534
SGTC_749 1000-0129 128 µM -0.214215114384682 0.402541553013373 no 2025 0.415189655036455 2942 708470
SGTC_940 3232-1287 54.8 µM -0.215411067413181 0.40207453583849 no 2026 0.41472342099737 2777 1585493 YIL048W NEO1
SGTC_2323 6148992 148.28 µM -0.215713527211748 0.401956448032957 no 2027 0.414605528133057 2848 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42
SGTC_1808 st050063 61.5 µM -0.215894087439721 0.401885957107968 no 2028 0.414535152982982 2915 4011993
SGTC_3317 9138495 8.753 µM -0.220117263611814 0.400238139176492 no 2029 0.412889915049676 2804 17020139
SGTC_2568 diosmetin 100 µM -0.220942290409866 0.399916432762157 no 2030 0.412568684009091 2899 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.
SGTC_74 000s-0487 160.283 µM -0.22159005602405 0.399663894183697 no 2031 0.412316512104788 2763 677548
SGTC_2347 9049783 174.81 µM -0.221929672520624 0.399531507704955 no 2032 0.412184315562322 2965 6467988 YPL169C MEX67
SGTC_705 1124-0212 310 µM -0.222138741755493 0.399450015817228 no 2033 0.41210293981087 2900 9554485
SGTC_2754 granisetron 64.02 µM -0.222685644995428 0.39923686229338 no 2034 0.411890087242753 2936 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients.
SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM -0.223723752687677 0.398832346312609 no 2035 0.411486131201428 2904 616764
SGTC_2555 cholic acid 100 µM -0.224145035643501 0.398668217346866 no 2036 0.411322225238704 2966 6708657 Influences liver metabolism.
SGTC_838 0109-0203 71.4 µM -0.225039098519586 0.39831995595143 no 2037 0.410974429016194 2800 759422
SGTC_3004 9076122 71.4286 µM -0.227003685608541 0.397554981567083 no 2038 0.41021043813863 2959 44782551
SGTC_3221 9128209 49.47 µM -0.22865012959809 0.396914189470761 no 2039 0.409570429359823 2852 16460723
SGTC_1741 st038134 10.228 µM -0.228998320958115 0.396778709803399 no 2040 0.409435110568384 3031 1272587
SGTC_1198 1612-1005 86.7 µM -0.22909352654336 0.396741667913462 no 2041 0.409398112375981 3006 6998509
SGTC_1383 3049-0032 20.7 µM -0.231513172859362 0.395800563322979 no 2042 0.408458076465284 2968 712864
SGTC_1804 st050076 49.1 µM -0.231513928442614 0.395800269538675 no 2043 0.408457783002105 2935 3895976
SGTC_1203 3992-3522 103 µM -0.231608158622704 0.395763631620624 no 2044 0.408421185070642 3175 5322312
SGTC_3048 9093155 49.47 µM -0.235093296350228 0.394409214347511 no 2045 0.407068160822515 2873 25236002
SGTC_146 3448-8650 53.125 µM -0.235131968198752 0.394394192563838 no 2046 0.407053153557791 2849 2891488 YIL048W NEO1
SGTC_576 1073-0113 22.7 µM -0.235786220581395 0.394140077053788 no 2047 0.406799280558145 2867 5439563
SGTC_2150 5556613 200 µM -0.236953908005881 0.393686652359152 no 2048 0.406346274036902 2868 743190
SGTC_1912 st060209 90.8 µM -0.237421827233952 0.393504995057754 no 2049 0.406164779036498 2888 688787
SGTC_1750 st081859 2.357 µM -0.238092782561678 0.393244554799509 no 2050 0.405904566241085 2862 5291695
SGTC_188 3229-0966 278.469 µM -0.238591320543215 0.393051071559012 no 2051 0.405711247996146 2867 5722370
SGTC_641 4092-0595 30 µM -0.238675928621772 0.393018237674249 no 2052 0.405678441773363 2887 786260
SGTC_1511 0906-3109 28.5 µM -0.238840411142955 0.392954409066563 no 2053 0.40561466665983 2797 2882180
SGTC_2476 5806916 10.51 µM -0.240906479035779 0.392152902439527 no 2054 0.40481380023276 2834 2870194
SGTC_876 0720-0963 56.8 µM -0.241146114220192 0.392059968337135 no 2055 0.404720936579015 3033 765861
SGTC_2106 5357045 167.29 µM -0.242048206505191 0.391710178738293 no 2056 0.404371405085687 2946 668842
SGTC_1869 3',7'-dimethoxyflavone 40.3 µM -0.242760657446057 0.391433985111774 no 2057 0.404095407381529 2841 688664
SGTC_983 1491-0821 12.2 µM -0.243863622980437 0.391006509900473 no 2058 0.403668221690663 2986 46495113
SGTC_298 1391-0729 10 µM -0.245122677049037 0.390518700554873 no 2059 0.403180722352274 2846 3237558
SGTC_2898 9056270 58.44 µM -0.245316960591119 0.390443442441676 no 2060 0.403105510131 2803 19154699
SGTC_2343 7990716 14.84 µM -0.245650483491075 0.390314257828064 no 2061 0.402976403086566 2834 6456862
SGTC_745 0469-0705 296 µM -0.246362978663847 0.390038325117893 no 2062 0.402700630951229 3039 3486736
SGTC_2827 7993847 71.43 µM -0.246719350607081 0.389900331377519 no 2063 0.402562714902334 2943 2985692
SGTC_1978 st071761 42 µM -0.247261315169755 0.389690499378747 no 2064 0.402352997701635 2865 5147680
SGTC_861 0443-0273 110 µM -0.247737783248619 0.38950605215628 no 2065 0.402168648061151 2934 6149169
SGTC_1644 st010134 20.9 µM -0.248075684959688 0.389375260925145 no 2066 0.402037924137616 2895 3818134
SGTC_2364 9055074 200 µM -0.249220801719359 0.388932115153059 no 2067 0.401594994765972 2931 6470630
SGTC_1797 st048695 56.8 µM -0.249428460809941 0.38885176915608 no 2068 0.401514686076577 2982 592262 YIL048W NEO1
SGTC_244 nsc-207895 1.295 µM -0.249764651734175 0.388721702603847 no 2069 0.401384678664164 2797 42640
SGTC_2894 9048625 32.47 µM -0.24999846144623 0.388631252954841 no 2070 0.40129426922688 3013 4092861
SGTC_2246 7293507 91.5585 µM -0.250338179372271 0.38849984330989 no 2071 0.401162916666071 3016 887656
SGTC_3331 9141060 1.957 µM -0.250851049405372 0.388301479167132 no 2072 0.400964635690674 2851 4906567 YPR165W RHO1
SGTC_2663 amphotericin b 100 µM -0.251127668931136 0.388194502368472 no 2073 0.400857702244411 2867 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_1146 3579-1023 7 µM -0.251196149247871 0.388168020352129 no 2074 0.40083123079765 2952 X1146
SGTC_1145 3546-0597 10.2 µM -0.25135609367254 0.388106170285556 no 2075 0.400769405165989 2892 875334
SGTC_3122 9126309 49.47 µM -0.251659217142281 0.387988961065382 no 2076 0.400652241287427 2882 17591206
SGTC_1259 0671-0132 43 µM -0.252772893081892 0.387558421953908 no 2077 0.400221857891731 2871 X1259
SGTC_774 k060-0086 136 µM -0.253316349086979 0.387348375922563 no 2078 0.400011881643422 2867 5911235
SGTC_82 0054-0107 293.755 µM -0.254006479113633 0.387081687835945 no 2079 0.399745276309171 2927 3104697
SGTC_2218 6965428 192.983 µM -0.254009190083207 0.387080640336498 no 2080 0.399744229121854 2874 675684
SGTC_488 nitrendipine 139 µM -0.254270850955319 0.386979540299706 no 2081 0.399643158735048 2845 4507 Dihydropyridine L-type calcium channel blocker.
SGTC_1563 conessine 56.1 µM -0.25455731025778 0.386868867484139 no 2082 0.399532517297897 2978 441082 An anti-amoebic, histamine inhibitor.
SGTC_1749 st037932 54.2 µM -0.254992883519419 0.386700602502878 no 2083 0.399364297862406 2995 594497
SGTC_265 mycophenolic acid 32.932 µM -0.255240514332939 0.386604950490315 no 2084 0.399268670577985 3090 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1
SGTC_3177 9107506 49.47 µM -0.25718230075839 0.385855138559864 no 2085 0.398519023267282 2977 8897194
SGTC_206 4546-0025 72.014 µM -0.258759880959673 0.385246276874725 no 2086 0.397910257081856 2926 6620745 YIL048W NEO1
SGTC_2228 7354201 200 µM -0.25924647358233 0.385058535104075 no 2087 0.397722537849069 2884 753451
SGTC_1931 st074438 57.1 µM -0.260349973257697 0.384632872305745 no 2088 0.397296914076722 2807 2787313
SGTC_2945 9067681 61.76 µM -0.263099281540372 0.383572962798444 no 2089 0.396237028845748 2807 16456930
SGTC_2398 5228213 48.84 µM -0.263843737535993 0.383286110614993 no 2090 0.395950165323172 3076 80771 YMR134W ERG29
SGTC_1844 rapamycin 4 nM -0.264293154054392 0.383112973366022 no 2091 0.395777017533985 2839 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2
SGTC_3074 9116018 49.47 µM -0.264297915398436 0.383111139188079 no 2092 0.395775183229481 2842 17027303
SGTC_743 1275-0778 158 µM -0.265550498392611 0.382628706892275 no 2093 0.395292706793671 2980 2849257 YMR203W TOM40
SGTC_3316 9136639 10.545 µM -0.26579285882252 0.382535382781209 no 2094 0.395199371647084 2971 4903665
SGTC_1991 st073000 8.92 µM -0.266676202594168 0.382195297274057 no 2095 0.39485923907105 3069 4301969 YIL048W NEO1
SGTC_731 3966-0296 387 µM -0.267151182382076 0.382012468595213 no 2096 0.394676380640518 2878 660956
SGTC_735 3076-0345 636 µM -0.267160774225181 0.382008776784767 no 2097 0.394672688197258 3036 2888990
SGTC_3115 9123671 49.47 µM -0.267318950156166 0.381947897900068 no 2098 0.394611798694298 2859 3286988
SGTC_478 N-arachidonylglycine 10 µM -0.267881843107473 0.381731274877387 no 2099 0.394395135090309 2941 5283389
SGTC_2163 5671233 125 µM -0.269479281046427 0.381116720725635 no 2100 0.393780442012618 3087 701023
SGTC_2798 7813637 45.45 µM -0.271816778630774 0.380217996979589 no 2101 0.392881451657904 3023 956368
SGTC_810 3825-7150 143 µM -0.272454040978398 0.379973093537299 no 2102 0.392636462481903 3075 22330411 YGL099W LSG1
SGTC_989 1501-0895 10.3 µM -0.27332064605858 0.379640129650591 no 2103 0.392303373036676 2969 2830112
SGTC_1223 0764-0573 147 µM -0.273626344530577 0.37952269655985 no 2104 0.392185893188101 2873 1609797
SGTC_3121 9125696 49.47 µM -0.273964378630806 0.379392854779475 no 2105 0.392055998206386 2901 1235365
SGTC_134 0269-0018 6.916 µM -0.274298448756141 0.379264548959043 no 2106 0.391927638263211 2962 4378915
SGTC_2473 5854593 8.94 µM -0.274722103717956 0.37910185554917 no 2107 0.391764874007713 2855 2872951
SGTC_1017 4239-0030 168 µM -0.275280504356814 0.378887449365247 no 2108 0.391550370671495 2895 1149593
SGTC_691 1548-0686 185 µM -0.275960601018483 0.378626366527193 no 2109 0.391289163711824 2910 46495133
SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM -0.276225270386873 0.378524777361452 no 2110 0.391187524521727 2934 2374 Ca(2+)-ATPase inhibitor.
SGTC_2433 5607874 27.82 µM -0.276916922869692 0.378259337105306 no 2111 0.390921948987125 2886 2252428
SGTC_2761 levamisole 97.89 µM -0.277244863044022 0.37813350130492 no 2112 0.390796046745154 3049 26879 An alkaline phosphatase inhibitor.
SGTC_1269 0831-0796 3.05 µM -0.278262249175024 0.377743196564431 no 2113 0.390405526462354 3028 927758
SGTC_1853 st056710 91.2 µM -0.280507556372021 0.376882260656696 no 2114 0.389544064469077 3061 269167
SGTC_1057 3448-5381 134 µM -0.281548049784439 0.376483503222885 no 2115 0.38914503972634 3039 5497911
SGTC_791 1348-1292 225 µM -0.283556406737059 0.375714195917883 no 2116 0.388375174351597 2962 5437054
SGTC_2035 5154463 94.595 µM -0.284071865123669 0.375516827512174 no 2117 0.388177653767811 3050 2769623
SGTC_1169 aniline yellow 25.8 µM -0.284971503890919 0.375172434960659 no 2118 0.387832986864028 2942 6051 A DNA damaging agent.
SGTC_2335 9018011 154.17 µM -0.284983318638301 0.375167912794359 no 2119 0.387828461020687 3005 6458208
SGTC_1959 st077091 55.8 µM -0.28546383406748 0.374984007142034 no 2120 0.387644404193695 2865 821356 YKL052C ASK1
SGTC_3111 9122088 49.47 µM -0.286906242789598 0.374432130962881 no 2121 0.387092055152244 2952 16876704
SGTC_1891 st059073 26.2 µM -0.288342464438341 0.373882877485469 no 2122 0.386542302423654 3110 688754
SGTC_299 1273-0059 1.44 µM -0.289222043439389 0.373546626876106 no 2123 0.386205732061496 3012 2848077
SGTC_2178 5812956 200 µM -0.289447155695749 0.373460585103333 no 2124 0.386119606744967 2872 5403383
SGTC_1338 1486-1223 76 µM -0.289615512190886 0.373396240480489 no 2125 0.386055199186414 2987 3444526
SGTC_1310 1188-0297 994 nM -0.290171034274084 0.373183949046621 no 2126 0.385842697321986 2957 1588352
SGTC_3336 9143619 71.43 µM -0.290272311244355 0.373145250441636 no 2127 0.385803959896471 3015 45595730
SGTC_1142 3253-1408 9.78 µM -0.290342323763262 0.37311849893988 no 2128 0.385777181475785 2996 256655
SGTC_2214 7179297 48.276 µM -0.2905329783843 0.373045653677564 no 2129 0.385704262567727 2922 769744
SGTC_1019 4262-0212 3.4 µM -0.291029860914896 0.372855826277506 no 2130 0.3855142408857 2995 4677213
SGTC_2226 7298446 200 µM -0.292162058171032 0.37242340066064 no 2131 0.385081359907001 3029 3283010
SGTC_1030 k029-0042 36.7 µM -0.292540020485547 0.372279079441374 no 2132 0.384936882753202 2985 6080581
SGTC_1232 0279-0259 161 µM -0.292594466020385 0.372258291423026 no 2133 0.384916072110755 2961 1560000
SGTC_3083 9117465 49.47 µM -0.293409864985559 0.371947005981912 no 2134 0.384604442970348 3029 16420915
SGTC_947 3447-0010 211 µM -0.294276452339631 0.371616270669308 no 2135 0.38427333237189 2912 748350
SGTC_2469 5655019 90.81 µM -0.294596180852703 0.371494269366356 no 2136 0.38415119000212 3047 2788239
SGTC_663 1486-0733 13.9 µM -0.29494799466454 0.371360039942106 no 2137 0.384016803732509 2923 722445 YPR165W RHO1
SGTC_1301 naphtanilide LB 4.81 µM -0.295133691970955 0.371289196152445 no 2138 0.383945876470079 3045 67238 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_420 mitomycin C 81.9 mM -0.296281392779594 0.370851443487109 no 2139 0.383507597395232 2928 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_1811 st050069 61.5 µM -0.296564036166347 0.370743664099903 no 2140 0.383399685594188 2942 3877702
SGTC_646 4092-0839 27.3 µM -0.297936541025857 0.370220436092622 no 2141 0.382875798997582 3068 877796
SGTC_2039 Aminomethylbenzodioxan 200 µM -0.298581025598401 0.36997482765022 no 2142 0.382629872380935 2906 15053
SGTC_2204 7233102 200 µM -0.301718294567135 0.368779995909503 no 2143 0.38143341040231 2946 2172480
SGTC_169 k015-0017 16.025 µM -0.302190310773072 0.368600337502076 no 2144 0.381253495031617 3164 1840002
SGTC_3003 9075612 71.4286 µM -0.303443176874435 0.368123612038381 no 2145 0.380776072693519 3017 6501993
SGTC_595 3909-8003 73.7 µM -0.303536424171286 0.368088138812261 no 2146 0.380740546740268 3066 699517
SGTC_2699 st077704 54.6 µM -0.304248579569256 0.367817257090095 no 2147 0.38046925839377 3004 645852
SGTC_605 1315-0399 119 µM -0.30443555696922 0.367746147602406 no 2148 0.380398040993672 3083 24020461
SGTC_501 nsc-95397 161 µM -0.306225774208601 0.367065538808607 no 2149 0.379716374727499 3101 262093
SGTC_1751 st044839 27.194 µM -0.308310319580811 0.366273557955081 no 2150 0.378923107188861 2945 5291326
SGTC_2019 4016004 108 µM -0.31189539541056 0.364912813893763 no 2151 0.377560011005761 3033 45595336
SGTC_1049 3226-0134 66 µM -0.311970185181987 0.364884444880977 no 2152 0.377531591050066 2993 5702385
SGTC_813 k007-0158 173 µM -0.312121676248823 0.364826984049028 no 2153 0.377474026795597 3009 6523916
SGTC_533 1222-0222 6.71 µM -0.312262761439366 0.364773472914842 no 2154 0.377420419060377 3129 3982874
SGTC_3235 9132602 49.47 µM -0.312265961573837 0.364772259190606 no 2155 0.377419203141848 3070 4912240
SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM -0.314079049649527 0.364084822283485 no 2156 0.376730500482613 3024 676296 Flavone; oxidizing agent.
SGTC_2434 5670830 169.91 µM -0.315098417825706 0.363698518085694 no 2157 0.376343464885379 3069 1549830
SGTC_982 1491-0518 27.5 µM -0.315647327943926 0.363490558072502 no 2158 0.376135105138088 2957 3091256
SGTC_1092 toremifene 6.32 µM -0.317530549482783 0.362777387060858 no 2159 0.375420531374861 2959 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_405 ebelactone b 50 µM -0.317971643425977 0.362610414623708 no 2160 0.375253223369742 2957 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).
SGTC_1854 st056233 32.9 µM -0.318414466524242 0.362442813907909 no 2161 0.375085283094294 3062 5393174
SGTC_418 lividomycin a 100 µM -0.31848681016546 0.36241543562251 no 2162 0.37505784908052 3099 72394 An antibiotic.
SGTC_1003 4049-0218 100 µM -0.319103086672956 0.362182235730529 no 2163 0.374824171552011 3125 295161
SGTC_2706 st078239 82.5 µM -0.320313093787451 0.361724516202437 no 2164 0.374365499120307 2971 15434492
SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM -0.320822224366474 0.36153198218677 no 2165 0.374172558173103 3013 66535 A nucleotide analog.
SGTC_1541 2',3',6-trimethoxyflavone 64 µM -0.322234869196021 0.360997956804475 no 2166 0.373637385161387 3025 688801
SGTC_1043 0916-0009 19.3 µM -0.322983103691022 0.360715209644011 no 2167 0.373354019092423 3156 3101130
SGTC_1123 mangostin 811.285 nM -0.324664311584224 0.360080182996579 no 2168 0.372717573927931 3038 5281650 An antioxidant.
SGTC_831 k061-1017 217 µM -0.325088063278578 0.35992018413098 no 2169 0.372557211432564 3056 1240153
SGTC_158 k038-0087 26.446 µM -0.325302308314501 0.359839299485974 no 2170 0.372476142006594 2940 X158
SGTC_1345 1488-0192 31.4 µM -0.325759980700151 0.359666533928583 no 2171 0.372302979619328 3126 658348
SGTC_3215 9129942 49.47 µM -0.327026244642126 0.359188684764047 no 2172 0.371824017629517 3116 17682944
SGTC_1512 0259-0544 12.2 µM -0.327093619983157 0.359163265540574 no 2173 0.371798538581759 2993 18476
SGTC_2388 9080168 200 µM -0.327911401319732 0.35885478449797 no 2174 0.371489326471972 2966 15943073
SGTC_2402 5553605 200 µM -0.329410807566116 0.358289422127514 no 2175 0.370922599988183 3174 6758546
SGTC_692 k241-0027 77.8 µM -0.331034191224328 0.357677663259293 no 2176 0.37030932964993 3170 3600480
SGTC_2308 7584454 197.62 µM -0.331903895589908 0.357350072501719 no 2177 0.369980914365176 3172 893577
SGTC_2528 xanthyletin 44.79 µM -0.332083535494895 0.357282420789439 no 2178 0.369913091059913 2979 65188 An natural product with antifungal activity of unknown mechanism.
SGTC_1456 k015-0012 13 µM -0.33215468796302 0.357255626277777 no 2179 0.36988622846145 3194 2989616
SGTC_1149 3909-7961 23.3 µM -0.33498173572136 0.356191590795105 no 2180 0.36881943192454 3026 735261
SGTC_1633 st005664 67.9 µM -0.33553178451749 0.355984694894517 no 2181 0.368611986165656 2954 2063822
SGTC_1801 st050089 28.441 µM -0.33560520893551 0.355957080167585 no 2182 0.368584297728095 2990 5008493 YIL048W | YNL267W NEO1 | PIK1
SGTC_2034 5197015 53.07 µM -0.335683281491742 0.355927718117274 no 2183 0.368554857220384 3144 780676
SGTC_987 1497-1013 404 µM -0.336302351066127 0.355694924547461 no 2184 0.36832143859178 3007 1676435
SGTC_1452 4194-0072 190 µM -0.336923095349848 0.355461555250301 no 2185 0.368087437307077 3151 1343545
SGTC_3144 9087057 49.47 µM -0.337438386301091 0.355267872366721 no 2186 0.367893225815894 3144 17249618
SGTC_781 4335-2806 94.4 µM -0.337496876209907 0.355245890072322 no 2187 0.367871183291689 3133 845254
SGTC_2285 7945142 200 µM -0.339552668602267 0.354473566955781 no 2188 0.367096713662913 3113 2970608
SGTC_198 3454-2873 16.191 µM -0.339680212508924 0.354425670741468 no 2189 0.367048682382492 3019 710957
SGTC_1713 st033146 12.748 µM -0.341041536644666 0.353914599963696 no 2190 0.366536156213921 3159 674619
SGTC_794 k038-0031 316 µM -0.341108101225799 0.353889616907632 no 2191 0.366511101347629 3055 6624242
SGTC_1653 st012112 65 µM -0.342049170577793 0.353536481592599 no 2192 0.366156944357726 3177 720429
SGTC_2698 st077697 67.5 µM -0.342153724484033 0.353497255618897 no 2193 0.366117604131881 3050 3154499
SGTC_2776 terbinafine 19.92 µM -0.342850964162401 0.353235708778152 no 2194 0.365855291578647 3060 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_59 0330-0160 1.33 µM -0.343753499871575 0.352897254724538 no 2195 0.365515836547544 3043 4293482
SGTC_2435 5706476 10.6 µM -0.344213676812895 0.352724731534315 no 2196 0.365342798728974 3158 5725375
SGTC_2933 9026794 32.47 µM -0.344646554087304 0.352562470799207 no 2197 0.365180051270537 3046 17586027
SGTC_2850 9015429 58.44 µM -0.345071376310708 0.352403255516932 no 2198 0.365020355848184 3067 6457570
SGTC_1786 berberine 21.6 µM -0.346098991925821 0.352018231723994 no 2199 0.364634160498334 3011 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_406 estrone 100 µM -0.346151238651912 0.351998660133111 no 2200 0.364614528959458 3195 5870 A steroid.
SGTC_2546 rhodinyl acetate 100 µM -0.346204532416318 0.351978696726283 no 2201 0.364594504365093 3159 6708682
SGTC_22 0964-0034 14.468 µM -0.347356384770576 0.351547322075516 no 2202 0.364161797832989 3068 138402
SGTC_2658 polymyxin b sulfate 77.05 µM -0.349187374645628 0.350862000431503 no 2203 0.363474321978711 3031 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides. YIL048W NEO1
SGTC_3036 9090181 49.47 µM -0.349707397842628 0.350667449144303 no 2204 0.363279150580199 2997 25236586
SGTC_2519 cryptotanshinone 88.04 µM -0.350752267967453 0.350276660337686 no 2205 0.362887104716113 3174 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE)
SGTC_1995 st072814 61.1 µM -0.350921968130163 0.35021320622544 no 2206 0.362823445045028 3026 5769371
SGTC_586 0957-0265 8.15 µM -0.351686366736651 0.34992743493304 no 2207 0.362536742994288 3115 6752309 YPR165W | YPR107C RHO1 | YTH1
SGTC_716 1683-5115 658 µM -0.351828119374566 0.349874449883701 no 2208 0.362483584471836 3033 723597
SGTC_101 0490-5701 117.494 µM -0.352851131262955 0.349492149832343 no 2209 0.362100024415253 3096 4661669
SGTC_1113 artemisinin 1.17947 µM -0.353846756450539 0.349120230730634 no 2210 0.361726865430408 3136 2240 An anti-malaria and mitochondrial poison.
SGTC_12 0849-0099 9.267 µM -0.353928283943953 0.349089782276522 no 2211 0.361696314853059 3089 6071388
SGTC_2641 levomentholum 100 µM -0.354445776657654 0.348896534515035 no 2212 0.361502416769983 3081 16666
SGTC_1680 diphenhydramine 100 µM -0.354499871906417 0.348876335939973 no 2213 0.361482150005355 3060 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1
SGTC_3176 9106582 49.47 µM -0.355234505137233 0.34860207433511 no 2214 0.361206958440295 3086 17018027
SGTC_3299 9121982 43.1275 µM -0.355365587453072 0.348553145512636 no 2215 0.361157862915018 3048 17594604 YPL160W CDC60
SGTC_3172 9105863 49.47 µM -0.356042299956325 0.348300590541144 no 2216 0.360904443642118 3078 2348785
SGTC_1476 4112-3294 3.34 µM -0.356636916673392 0.348078729929166 no 2217 0.360681818468676 3159 704369
SGTC_3000 9075062 71.4286 µM -0.357110033330643 0.347902239987283 no 2218 0.360504716774523 3042 17057871
SGTC_2497 7-hydroxyflavone 100 µM -0.357246825099498 0.347851217756849 no 2219 0.360453517104602 3184 5281894
SGTC_1408 3909-7976 48.8 µM -0.358470311834476 0.347394989652775 no 2220 0.359995690703276 3074 24152374
SGTC_1572 epiandrosterone 68.9 µM -0.358585019671453 0.347352227368518 no 2221 0.359952777533335 2978 441302 A steroid.
SGTC_1107 amlodipine 47 µM -0.359198042157662 0.347123729796176 no 2222 0.35972347058193 3100 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.
SGTC_1819 st053448 58.6 µM -0.359901703950472 0.346861515892675 no 2223 0.35946032136764 3039 2857616
SGTC_3270 9137563 49.47 µM -0.359948871721638 0.346843941823368 no 2224 0.359442684363455 3112 17015724
SGTC_419 nsc-638432 893 µM -0.360061631099663 0.346801930549865 no 2225 0.359400522515883 3109 368090
SGTC_2304 7443016 91.4 µM -0.363678165653086 0.345455503339653 no 2226 0.35804917488024 2981 939854
SGTC_1324 1418-0026 34.4 µM -0.36373883935057 0.345432931278596 no 2227 0.358026518764784 3143 1372513
SGTC_3136 9095672 49.47 µM -0.364989260749007 0.344967867223075 no 2228 0.357559711379187 3037 17217380
SGTC_2480 5767542 37.17 µM -0.365051000785152 0.344944910566116 no 2229 0.357536668098348 3073 2867358
SGTC_575 k072-0246 11.9 µM -0.365267041027171 0.34486458530849 no 2230 0.357456039322534 3077 6796779
SGTC_482 fipronil 114 µM -0.365417719435118 0.344808566171788 no 2231 0.357399808122953 3106 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels.
SGTC_2856 9022925 19.48 µM -0.365950473269936 0.344610526527544 no 2232 0.357201016233375 3195 4944862
SGTC_562 3772-2733 112 µM -0.366684183165309 0.344337855550145 no 2233 0.356927302999269 3177 2876874 YIL048W NEO1
SGTC_173 1273-0061 2.693 µM -0.367055604924411 0.344199853711328 no 2234 0.356788770778965 3145 2847414 YPL266W DIM1
SGTC_1417 3966-0327 90.4 µM -0.368678153041158 0.343597239049018 no 2235 0.356183817363589 3106 651118
SGTC_2371 9071574 200 µM -0.371274625701066 0.342633735628273 no 2236 0.3552164976223 3170 45596039
SGTC_1951 sophoraflavanone G 9.2 µM -0.373098207718064 0.341957648825897 no 2237 0.354537676282731 3065 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity.
SGTC_2201 6605497 169.863 µM -0.374702170002276 0.341363403814737 no 2238 0.353940989112234 3086 670741
SGTC_1683 st010134 710 nM -0.375239558591281 0.341164396896208 no 2239 0.353741156246836 3036 3818134
SGTC_2000 st075254 36.4 µM -0.38128651184885 0.338928132305779 no 2240 0.351495330542234 3092 17234175
SGTC_2284 7945075 39.21 µM -0.381522088820866 0.338841126134284 no 2241 0.35140794196754 3212 1245402
SGTC_2352 9027995 87.8 µM -0.382071525106339 0.338638235014444 no 2242 0.3512041560799 3120 2997347
SGTC_2656 pseudo-anisatin 100 µM -0.382156635025434 0.338606810539915 no 2243 0.351172592640545 3090 6708809 A neurotoxin.
SGTC_1392 3455-1037 33.9 µM -0.382554399081646 0.338459962105638 no 2244 0.351025093463507 3225 981132
SGTC_1940 st075990 51.1 µM -0.383043169263156 0.338279549230454 no 2245 0.35084387805856 3328 1084979
SGTC_502 l-744,832 89.3 µM -0.383290745621332 0.338188179006739 no 2246 0.350752100109882 3180 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.
SGTC_1296 1068-0102 11.9 µM -0.384503389974264 0.337740779718287 no 2247 0.350302691910432 3165 767053
SGTC_2736 butenafine 14.65 µM -0.3850225709318 0.337549300435792 no 2248 0.350110346518961 3093 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM -0.385721944522162 0.337291430737868 no 2249 0.349851304411793 3097 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_2857 9024691 58.44 µM -0.387617811882635 0.336592780179412 no 2250 0.349149442789832 3162 16478292
SGTC_2414 st077232 92.9 µM -0.388018391617732 0.336445233647736 no 2251 0.349001211643248 3023 729801
SGTC_1428 4049-0204 61.7 µM -0.388785277454395 0.336162834944162 no 2252 0.348717496306596 3190 X1428
SGTC_2147 5545932 89.7195 µM -0.388869956387819 0.336131658364526 no 2253 0.348686173863904 3120 797404
SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM -0.39002901977938 0.335705034767605 no 2254 0.348257544108912 3056 2333 A French combination drug.
SGTC_1196 1588-0294 184 µM -0.390148971734745 0.335660895390388 no 2255 0.348213196089721 3136 6144269
SGTC_2967 9089538 49.85 µM -0.390659408866224 0.335473092406476 no 2256 0.348024503115181 3291 728216
SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM -0.390736879514754 0.335444592548256 no 2257 0.347995867876456 3189 17037758
SGTC_1718 roemerine 11.9335 µM -0.391063537800639 0.335324432098535 no 2258 0.347875135708569 3191 235224 An aporphine alkaloid with mutagenic activity.
SGTC_2070 5230947 200 µM -0.391347039460409 0.335220160361435 no 2259 0.347770366632491 3203 2835538
SGTC_1078 idebenone 36.1 µM -0.396318485059566 0.333393735187408 no 2260 0.345935046111227 3159 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen.
SGTC_6 0844-0013 19.835 µM -0.396505978464979 0.333324930166561 no 2261 0.345865899170883 3204 1584900
SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM -0.399012763787697 0.332405547112399 no 2262 0.344941899744286 3285 23847180
SGTC_3356 9151811 4.48 µM -0.401244000292444 0.33158807085398 no 2263 0.344120244308968 3083 1859254 YPR165W RHO1
SGTC_2786 7743617 45.45 µM -0.401567289712093 0.331469691068503 no 2264 0.344001253509431 3122 583674
SGTC_723 4182-0001 115 µM -0.402649361659475 0.331073588298655 no 2265 0.343603095543801 3122 744821 YLR208W SEC13
SGTC_278 4092-0821 23.9 µM -0.403751946386184 0.330670171008574 no 2266 0.343197568122514 3197 877900
SGTC_2830 7992007 71.43 µM -0.404156161161532 0.330522324819255 no 2267 0.343048944307622 2973 1952075
SGTC_263 alizarin 107.927 µM -0.405599308125767 0.329994693146628 no 2268 0.342518518654062 3162 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium.
SGTC_2216 7189485 200 µM -0.40588492112709 0.329890309674974 no 2269 0.342413578955641 3222 731273
SGTC_827 3253-0474 693 µM -0.407319198480958 0.329366322280702 no 2270 0.341886781998923 3243 5402065
SGTC_957 1187-1561 14.1 µM -0.407725813244683 0.32921783379142 no 2271 0.341737492050828 3220 1538454
SGTC_63 0099-0242 26.702 µM -0.408910037619255 0.328785529616545 no 2272 0.341302841247809 3233 3898502 YLR359W ADE13
SGTC_590 k048-0076 22.4 µM -0.409095036778026 0.328718015860425 no 2273 0.341234959227303 3239 6832814
SGTC_331 k048-0133 24.5 µM -0.41011191957407 0.328347013612385 no 2274 0.34086192466679 3111 6813582
SGTC_1798 st045719 60.953 µM -0.411524694123871 0.327831854053617 no 2275 0.340343918901179 3224 3980186
SGTC_1271 0832-2808 169 µM -0.411638164029979 0.327790492143637 no 2276 0.340302327248628 3254 3663794
SGTC_445 e6 berbamine 66 µM -0.411989516417215 0.32766243100617 no 2277 0.340173553649736 3207 6610268 A calcium/calmodulin antagonist.
SGTC_334 1502-1024 68.5 µM -0.412059330114226 0.327636987679696 no 2278 0.340147968563145 3227 3296216
SGTC_2719 novobiocin 32.65 µM -0.412973006453424 0.327304075757615 no 2279 0.339813195446892 3247 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication.
SGTC_1397 3532-0190 20.1 µM -0.413142748114178 0.327242242909492 no 2280 0.339751015615103 3053 5322280
SGTC_2789 5281112 71.43 µM -0.413362142986946 0.32716232960123 no 2281 0.339670653259593 3153 765948
SGTC_2423 st077119 87.2 µM -0.413754791246947 0.327019329532412 no 2282 0.339526847951592 3181 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae).
SGTC_305 1682-2595 20.8 µM -0.413989799132451 0.326933753260043 no 2283 0.339440788754697 3191 226033
SGTC_1601 4'-hydroxyflavanone 55.5 µM -0.414280478476979 0.326827917254118 no 2284 0.339334354415882 3298 165506
SGTC_1830 st055982 50.3 µM -0.417374197574808 0.325702362342069 no 2285 0.338202362420955 3248 455313 An antimicrobial agent.
SGTC_3248 9135562 49.47 µM -0.418591128198122 0.325260053757016 no 2286 0.337757487241292 3186 17650701
SGTC_2033 5192550 145 µM -0.418982862987542 0.325117725193456 no 2287 0.337614328335745 3158 182073
SGTC_3085 9117376 49.47 µM -0.419727188790396 0.324847360437672 no 2288 0.337342380307627 3243 16480349
SGTC_1848 st056003 16.4 µM -0.42020165414991 0.324675066411053 no 2289 0.337169073234088 3247 146492
SGTC_151 3013-0144 2.285 µM -0.42045805807942 0.324581973293814 no 2290 0.337075431428825 3299 906558 YHR107C CDC12
SGTC_3291 9121177 71.43 µM -0.421860373556349 0.324073025638181 no 2291 0.336563467629372 3150 17015612
SGTC_1552 6-methylflavone 10.6 µM -0.422008371846592 0.324019331215192 no 2292 0.336509453380492 3250 689013
SGTC_2022 5136654 200 µM -0.422239746987761 0.323935394644285 no 2293 0.336425016229261 3257 1713771
SGTC_3116 9124943 49.47 µM -0.422616861779644 0.323798606901905 no 2294 0.336287411092679 3163 41905195 YPL160W CDC60
SGTC_3208 9114115 49.47 µM -0.423557837138455 0.323457398456768 no 2295 0.335944154951095 3206 650895
SGTC_2389 9091542 195.52 µM -0.423847107308524 0.323352535589056 no 2296 0.335838660256084 3185 3626624 YOL127W RPL25
SGTC_2541 muurolladie-3-one 83.07 µM -0.425387881906133 0.322794228420752 no 2297 0.335276969225112 3313 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils. YMR203W TOM40
SGTC_1730 st033808 45.1 µM -0.425533760809061 0.322741389157863 no 2298 0.335223807969324 3125 1045166
SGTC_1553 gossypol 38.6 µM -0.427207169272768 0.32213551475341 no 2299 0.334614219977189 3161 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_3234 9132280 49.47 µM -0.427265251825762 0.32211449385251 no 2300 0.334593069522513 3227 17612295
SGTC_279 1273-0055 2.93 µM -0.428201053840527 0.321775892290799 no 2301 0.33425237455846 3219 2847562
SGTC_3203 9113543 49.47 µM -0.428278491856873 0.321747879491674 no 2302 0.334224188016111 3271 17018012
SGTC_2567 aureobasidin a 60 nM -0.428315632490561 0.321734444420374 no 2303 0.334210669586675 3350 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1
SGTC_2610 ononetin 44.17 µM -0.428353160836906 0.321720869336547 no 2304 0.334197010256205 3219 259632
SGTC_2240 6690706 185.951 µM -0.42996209707578 0.321139094785924 no 2305 0.33361160651683 3038 805876
SGTC_726 3448-4391 34.2 µM -0.430554607471481 0.320924959663084 no 2306 0.333396126376649 3352 1356692
SGTC_2818 7996756 12.99 µM -0.432437642071556 0.320244820672725 no 2307 0.332711682399005 3088 2241621
SGTC_3189 9110682 49.47 µM -0.433471429968395 0.319871680115436 no 2308 0.332336158723163 3261 17122418
SGTC_1046 2001-0062 216 µM -0.433690987637688 0.319792455319204 no 2309 0.332256426001565 3159 739778
SGTC_1161 k007-0610 110 µM -0.434935438266107 0.31934356541208 no 2310 0.331804645303795 3298 5843850
SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM -0.438851215829761 0.317932821350903 no 2311 0.330384673547654 3142 442882
SGTC_2048 5246248 200 µM -0.438927453281422 0.317905381268235 no 2312 0.330357051828858 3290 677046
SGTC_3077 9117319 49.47 µM -0.439595602868509 0.317664937534842 no 2313 0.330115012993978 3234 17154678
SGTC_486 niguldipine 82 µM -0.442436553268511 0.316643438001493 no 2314 0.329086666414861 3168 1236 A calcium channel blocker.
SGTC_79 0052-0007 94.094 µM -0.442954418766754 0.316457383216551 no 2315 0.328899352225538 3320 2801472
SGTC_3090 9117696 49.47 µM -0.443343835055576 0.3163175072766 no 2316 0.3287585269685 3205 7923821
SGTC_1482 3346-2049 8.48 µM -0.44442832921285 0.315928102170681 no 2317 0.328366467731466 3269 3826804
SGTC_1437 4092-1038 11.6 µM -0.444623791010729 0.315857940164726 no 2318 0.328295825742694 3195 3977136
SGTC_3169 9102970 49.47 µM -0.446957137102412 0.315020886587828 no 2319 0.327453004131853 3288 17027839
SGTC_760 0568-0725 82.9 µM -0.446979067954284 0.315013023713157 no 2320 0.327445086709985 3305 3916171
SGTC_2020 4017018 200 µM -0.448008433253904 0.314644059434183 no 2321 0.327073555162263 3282 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope.
SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM -0.448510922811648 0.31446401494344 no 2322 0.326892252473516 3325 688798
SGTC_1620 st003704 16.5 µM -0.450046529898522 0.31391407290974 no 2323 0.326338445180571 3323 2834414
SGTC_2227 7312221 64.1025 µM -0.450727691013636 0.313670263046913 no 2324 0.32609291103068 3250 887188 YOR168W | YOR169C GLN4 | YOR169C
SGTC_2124 5246320 200 µM -0.452349641050624 0.313090041694652 no 2325 0.325508559798544 3281 579342
SGTC_2156 5649887 115 µM -0.456107777832509 0.311747419932424 no 2326 0.324156238714883 3296 54680440 YKL052C | YBR257W ASK1 | POP4
SGTC_2013 4024628 200 µM -0.457886463073401 0.311112841528904 no 2327 0.323517006418069 3330 5230760
SGTC_1361 1608-0041 5.61 µM -0.458273776143614 0.310974734853987 no 2328 0.323377880960733 3211 X1361
SGTC_480 am 92016 50 µM -0.458821774143427 0.310779377211036 no 2329 0.323181078583726 3256 2129 K+ channel blocker.
SGTC_1849 st056239 19.2 µM -0.459266843588531 0.310620752155772 no 2330 0.323021277318968 3179 5393181
SGTC_1661 st013063 9.66 µM -0.461926823123419 0.309673456375638 no 2331 0.322066898935511 3234 721395
SGTC_2571 chrysanthemic acid 100 µM -0.462179421043708 0.309583564494689 no 2332 0.321976329762849 3228 2743 An insecticide.
SGTC_1309 pyrazolanthrone 13.4 µM -0.464612969737953 0.308718122949621 no 2333 0.32110432132952 3310 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14
SGTC_1405 3909-7894 12 µM -0.465169433420409 0.308520376993869 no 2334 0.320905063133739 3307 7104060
SGTC_1448 4255-0083 152 µM -0.465248779760983 0.308492184854706 no 2335 0.320876655041614 3355 5399660
SGTC_52 0329-0193 875 nM -0.46919023216654 0.307093191538172 no 2336 0.319466833382265 3407 3739292
SGTC_891 0929-0073 133 µM -0.469290806338314 0.307057529978175 no 2337 0.319430892924546 3335 5603632
SGTC_376 3970-0862 59.1 µM -0.469450005439114 0.307001084939251 no 2338 0.319374006154475 3319 3135186
SGTC_3024 9090631 49.47 µM -0.469633093232727 0.306936175669643 no 2339 0.319308588470653 3325 25236383
SGTC_1265 0819-1001 68.8 µM -0.471566932800445 0.306250950294792 no 2340 0.318617966997242 3333 3106768
SGTC_2225 6654152 15.4 µM -0.471860425236772 0.306147015031699 no 2341 0.318513208629892 3281 97582 YGR029W | YLR033W ERV1 | RSC58
SGTC_1097 itavastatin 7.23 µM -0.473820144938356 0.305453414454253 no 2342 0.317814083941415 3265 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49
SGTC_1556 plumbagin 1.48 µM -0.474420838222736 0.305240951598856 no 2343 0.317599918073822 3298 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_2988 9073640 71.4286 µM -0.474875174817693 0.305080298099767 no 2344 0.317437973455106 3410 9102229
SGTC_292 k038-0015 474 µM -0.476156080795199 0.304627571787255 no 2345 0.31698159301543 3339 46368540
SGTC_1088 bifonazole 369 nM -0.477751351439955 0.304064153925282 no 2346 0.316413595158741 3303 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase.
SGTC_1989 st071868 50.2 µM -0.478076133191973 0.303949504398221 no 2347 0.316298009242689 3345 16414057
SGTC_1033 k072-0102 21.3 µM -0.480084467379816 0.303240981295534 no 2348 0.315583666223919 3356 5965931
SGTC_232 clozapine 119 µM -0.480325326040852 0.303156058032865 no 2349 0.315498041558742 3294 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_631 k072-0230 41.5 µM -0.480864961246685 0.302965829125577 no 2350 0.315306238525307 3316 5773147
SGTC_37 0566-0070 1.56 µM -0.48247813740884 0.30239748093932 no 2351 0.314733162762687 3292 1626686
SGTC_1709 st033179 39.1045 µM -0.482785008447947 0.302289419438772 no 2352 0.314624198230394 3246 573381
SGTC_2549 cedrol 20.94 µM -0.483913807032421 0.301892073719316 no 2353 0.314223520576805 3347 6708665 A sedative which affects the nervous system.
SGTC_2970 9090938 41.86 µM -0.48579352273153 0.301230920791798 no 2354 0.313556783596001 3406 17217104
SGTC_895 0964-0006 13.7 µM -0.486403991551324 0.301016340808758 no 2355 0.313340380539084 3374 6738897
SGTC_2492 derrusnin 100 µM -0.487465012602395 0.300643555625514 no 2356 0.312964415632473 3292 1715307 Part of coumarin class of compounds.
SGTC_122 0236-0016 402.397 µM -0.488240708609751 0.300371150111693 no 2357 0.31268967652666 3322 6808838
SGTC_2345 9052315 157.45 µM -0.488568465163512 0.300256083533033 no 2358 0.312573621660688 3331 6469265
SGTC_1288 0973-0013 65.5 µM -0.489044516686038 0.300088990047659 no 2359 0.312405090332613 3376 4315430
SGTC_1346 1488-2224 62.4 µM -0.489463346366296 0.299942016147396 no 2360 0.312256849069492 3369 3722427
SGTC_1335 1486-0900 202 µM -0.491864488743907 0.299100047132196 no 2361 0.311407571866622 3333 X1335
SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM -0.492576619124492 0.298850542558265 no 2362 0.311155885955077 3562 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W
SGTC_1637 st007924 17.4 µM -0.493322415183783 0.298589344184199 no 2363 0.310892396323097 3283 683336
SGTC_2442 5158906 48.48 µM -0.494428088863705 0.298202297917687 no 2364 0.31050194038073 3356 1893835
SGTC_2902 5787006 60.46 µM -0.494763790703765 0.298084829147159 no 2365 0.310383433351566 3215 591003
SGTC_351 caspofungin 25 nM -0.495166765382548 0.297943848119965 no 2366 0.310241204146482 3293 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1
SGTC_2524 avocatin b 10.57 µM -0.49652075197899 0.297470377577549 no 2367 0.309763524913334 3310 6710748
SGTC_848 0368-0089 85.6 µM -0.496552220315951 0.297459377618214 no 2368 0.309752426866963 3353 762535
SGTC_116 0155-0182 31.788 µM -0.496855662714275 0.297353316911478 no 2369 0.309645419694746 3278 771486
SGTC_493 zm226600 134 µM -0.498300060339825 0.296848700824595 no 2370 0.30913628267071 3426 5240098 A potassium channel opener. YCR052W RSC6
SGTC_738 1315-0003 72.4 µM -0.499460585890666 0.296443542724891 no 2371 0.308727473333641 3395 6251474
SGTC_1430 4049-0248 69.1 µM -0.499744319296606 0.296344525409082 no 2372 0.308627560789497 3375 22774488
SGTC_194 1486-1323 56.904 µM -0.500381667053177 0.296122159025254 no 2373 0.308403179813957 3319 5178754
SGTC_2235 salicylic acid 500 µM -0.500921901517291 0.295933734796696 no 2374 0.308213044006816 3349 338 A COX inhibitor and kinase inhibitor.
SGTC_1948 st076329 66.6 µM -0.50131248559523 0.295797540275591 no 2375 0.308075609774023 3309 24208413
SGTC_3063 1327-0034 4 µM -0.502469287429014 0.295394338864352 no 2376 0.307668725571317 3339 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_3157 9099274 49.47 µM -0.502951999591148 0.295226165119731 no 2377 0.307499010156741 3404 17217662
SGTC_200 k038-0079 37.545 µM -0.503467918874979 0.295046470973977 no 2378 0.307317665091604 3275 3436683
SGTC_1655 st012546 55.1 µM -0.506649093495612 0.29393958590978 no 2379 0.306200527590028 3349 720985 YLR208W SEC13
SGTC_1842 st055362 61.2 µM -0.508729232483632 0.293216844529937 no 2380 0.305471014594943 3292 676032
SGTC_616 4092-0450 108 µM -0.510144701396691 0.292725513373427 no 2381 0.304975045043888 3343 787165
SGTC_1782 st039423 80.636 µM -0.511435158406541 0.292277909250805 no 2382 0.304523190670529 3292 2068169
SGTC_2595 hexamethylquercetagetin 100 µM -0.511535168716894 0.29224323326495 no 2383 0.304488184434621 3291 386331
SGTC_3236 9132701 49.47 µM -0.513283873840352 0.29163722456318 no 2384 0.3038763813475 3356 24282524
SGTC_2720 fluspirilene 36.88 µM -0.516590400637967 0.290492961190899 no 2385 0.302721059065585 3367 3396 An atypical antipsychotic.
SGTC_2457 5731572 11.68 µM -0.5174385670989 0.29019978197252 no 2386 0.302425021495756 3406 2865357
SGTC_689 0833-0039 98 µM -0.519704582440883 0.289417186461646 no 2387 0.301634746260867 3364 5374726
SGTC_1896 st058441 89 µM -0.521910968565257 0.288656138594477 no 2388 0.300866160487873 3319 688759
SGTC_1199 1638-0010 4.46 µM -0.524489137304509 0.287768047949437 no 2389 0.299969186598441 3292 3111136
SGTC_2264 7948757 110.76 µM -0.525167509758737 0.287534586607894 no 2390 0.299733374440318 3256 2971411
SGTC_778 3456-2434 196 µM -0.525827223250629 0.287307632658701 no 2391 0.299504128970481 3406 5539063
SGTC_2751 anetholtrithion 17.25 µM -0.527953593651549 0.286576698399386 no 2392 0.298765772782656 3397 2194 A chloretic substance that stimulates the liver to produce bile.
SGTC_2966 9084041 48.03 µM -0.529246625364883 0.28613265383351 no 2393 0.298317188186402 3174 17741380
SGTC_2914 7968218 45.32 µM -0.530428929181038 0.28572692101001 no 2394 0.297907286398053 3370 2977111
SGTC_1325 1431-0015 227 µM -0.531260571485785 0.28544168923886 no 2395 0.297619112013786 3309 1103340
SGTC_1887 st057648 70.8 µM -0.53172270028096 0.285283249654871 no 2396 0.297459033659353 3435 688672
SGTC_3053 9095903 49.47 µM -0.532659288874401 0.284962271401113 no 2397 0.297134726226988 3436 17174018
SGTC_1921 5740136 50 µM -0.53298384678881 0.284851082363961 no 2398 0.297022381052718 3445 1774243
SGTC_2774 tamoxifen 10.92 µM -0.533815113343042 0.284566396415548 no 2399 0.296734728179985 3439 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.
SGTC_3138 9097216 49.47 µM -0.534822993446024 0.284221407531819 no 2400 0.296386130838343 3436 25237486
SGTC_276 colchicine 750 µM -0.535771971254538 0.283896763294477 no 2401 0.296058077846122 3467 2833 A microtubule depolymerizer.
SGTC_2602 kawain 100 µM -0.535793322652758 0.283889461047228 no 2402 0.296050698779385 3423 5369129
SGTC_1473 k844-0725 134 µM -0.535799109603331 0.2838874819069 no 2403 0.296048698817434 3471 54682906
SGTC_559 1550-0661 158 µM -0.536790258116374 0.283548606028704 no 2404 0.295706250814965 3412 5830875
SGTC_2735 sertaconazole 140 nM -0.538323411041053 0.283024799769219 no 2405 0.29517689577964 3429 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C
SGTC_607 4491-0986 66.8 µM -0.538863866618419 0.282840262301919 no 2406 0.294990395572467 3468 698981 YDR232W HEM1
SGTC_1695 st026914 34.495 µM -0.539580015473813 0.282595823780235 no 2407 0.294743350859418 3381 3289191
SGTC_1659 st012954 42.1 µM -0.539972621401449 0.282461861210921 no 2408 0.294607956919119 3437 24207262
SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM -0.541316210005602 0.282003641439672 no 2409 0.294144824693608 3345 115019
SGTC_1623 st003709 20.3 µM -0.543052208485347 0.28141212418467 no 2410 0.293546928267024 3390 16192618
SGTC_1543 azetidyl-2-carboxylic acid 198 µM -0.543874831197723 0.281132036211228 no 2411 0.293263804875769 3430 16486 A toxic proline analog.
SGTC_2903 5923464 63.88 µM -0.544643986011806 0.280870274944552 no 2412 0.292999198177657 3448 2876576
SGTC_2012 4023501 200 µM -0.545700953889523 0.280510756519347 no 2413 0.292635758069718 3356 3477460
SGTC_473 2-arachidonoylglycerol 10 µM -0.548800893383102 0.279457625470717 no 2414 0.291571048568975 3312 5282280 An endocannabinoid.
SGTC_2329 6138490 200 µM -0.549341668932932 0.279274106674602 no 2415 0.291385498244731 3437 720019
SGTC_492 tmb-8 126 µM -0.549645754228611 0.279170937341879 no 2416 0.291281185031951 3366 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1
SGTC_1021 4476-0760 85.3 µM -0.550545771331418 0.278865690301325 no 2417 0.290972545962114 3343 746768
SGTC_153 4077-0274 519.67 µM -0.553600967549904 0.277830712345495 no 2418 0.289925981861943 3575 3121976
SGTC_756 0508-1999 28.3 µM -0.554047150824602 0.277679720428453 no 2419 0.289773288656639 3348 6753853
SGTC_632 0781-2353 4.65 µM -0.554261331421092 0.277607254277064 no 2420 0.289700005003424 3453 6811515 YHR007C ERG11
SGTC_1946 st076057 65.1 µM -0.554823650441016 0.277417042487348 no 2421 0.2895076443313 3367 953009
SGTC_1510 1123-0200 71.5 µM -0.555966030685009 0.277030813685305 no 2422 0.289117038474482 3549 5378812 YNL149C | YNL150W PGA2 | YNL150W
SGTC_2271 7849410 118.62 µM -0.556106447009003 0.276983358320341 no 2423 0.289069044039354 3472 972430
SGTC_1539 benzyladenosine 56 µM -0.557959022212023 0.276357631398157 no 2424 0.288436183180199 3389 92208 A nucleotide analog.
SGTC_2977 9011197 71.43 µM -0.558065266665436 0.276321767241242 no 2425 0.288399908670115 3507 2704722
SGTC_3049 9092223 49.47 µM -0.558296832684263 0.27624360711993 no 2426 0.288320853700015 3429 8623917
SGTC_21 0849-0113 22.993 µM -0.560131593497913 0.275624706921895 no 2427 0.287694841094476 3408 1560156
SGTC_3084 9116877 49.47 µM -0.56300241703011 0.274657692783192 no 2428 0.286716619040228 3405 27241325
SGTC_624 k048-0052 28 µM -0.563108095519088 0.27462212777799 no 2429 0.286680639616293 3399 6835531
SGTC_713 1488-1073 324 µM -0.563927582814107 0.274346414911358 no 2430 0.286401708692861 3450 3312542
SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM -0.564231924429198 0.274244055334472 no 2431 0.286298151993328 3549 6710655
SGTC_250 brefeldin a 552.239 µM -0.564311454168188 0.274217310111357 no 2432 0.28627109376296 3390 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.
SGTC_2177 5811945 192 µM -0.564345216470479 0.274205956505261 no 2433 0.286259607255353 3482 5343475
SGTC_301 4119-0100 24.5 µM -0.564845436027561 0.27403776959672 no 2434 0.286089449728816 3431 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1
SGTC_2587 piperic acid 92.2 µM -0.566037342109262 0.273637225131145 no 2435 0.285684197970968 3367 5370536
SGTC_1294 1000-1494 117 µM -0.567352579016707 0.273195571324228 no 2436 0.285237330567157 3415 712797 YDL207W GLE1
SGTC_1781 st038725 66.3 µM -0.569361912355851 0.272521524053915 no 2437 0.28455527942228 3388 4270275 YIL048W NEO1
SGTC_1870 st057514 26.5 µM -0.569694487254607 0.272410038786758 no 2438 0.284442464866354 3399 5393161
SGTC_2923 7992654 58.14 µM -0.569699087155491 0.272408496973602 no 2439 0.284440904658568 3427 2985126
SGTC_962 1254-0300 21.5 µM -0.569979234368973 0.272314604282495 no 2440 0.284345891218361 3415 7340576
SGTC_1998 st075797 76.8 µM -0.570048715800537 0.272291319733936 no 2441 0.284322328563303 3488 24208315
SGTC_1696 st025591 34.7925 µM -0.570587766434089 0.272110707234888 no 2442 0.284139556555549 3472 2787147
SGTC_1053 3366-3204 134 µM -0.571236768748196 0.271893333744136 no 2443 0.283919578602334 3425 3632071 YPR165W RHO1
SGTC_3297 9117502 71.43 µM -0.573182142763827 0.271242278198453 no 2444 0.283260686979725 3470 7453720
SGTC_697 0508-1955 564 µM -0.574315317470361 0.270863398747869 no 2445 0.282877222852648 3500 6243113
SGTC_3232 9132874 49.47 µM -0.574537617321286 0.270789103306639 no 2446 0.282802026274049 3417 3784940
SGTC_1409 3909-8004 61.9 µM -0.575658361270491 0.270414691403922 no 2447 0.282423062519049 3447 2119279
SGTC_2804 7954240 19.48 µM -0.575824100248813 0.270359344215917 no 2448 0.282367040959159 3487 828705
SGTC_1453 4237-0541 195 µM -0.576390845461022 0.270170127045029 no 2449 0.282175515376756 3461 739892
SGTC_2327 6189656 200 µM -0.578092048491396 0.269602550645802 no 2450 0.281600987576178 3482 5349088
SGTC_1827 berberine 7.24 µM -0.578387718426214 0.269503966557274 no 2451 0.28150119193268 3366 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_1588 farnesol 29.9 µM -0.578870526500465 0.26934302456684 no 2452 0.281338269397665 3502 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_1496 4469-0713 57.4 µM -0.57977584403404 0.26904137083354 no 2453 0.281032894707308 3500 746691
SGTC_1976 st070609 63.5 µM -0.580604249507313 0.268765493005537 no 2454 0.280753603793842 3456 682556
SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM -0.580940299606867 0.268653621221566 no 2455 0.280640345216355 3468 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair.
SGTC_2835 9006588 71.43 µM -0.581327220145976 0.268524843547933 no 2456 0.280509969216041 3534 2345538
SGTC_2447 5741742 33.78 µM -0.584084164108178 0.267608156847413 no 2457 0.279581844254098 3487 1776504
SGTC_3280 9140961 49.47 µM -0.584546627320858 0.267454542000924 no 2458 0.279426302185331 3390 4901226
SGTC_258 haloperidol 50.781 µM -0.584958805963294 0.267317667502005 no 2459 0.279287707956641 3457 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_72 0744-0168 198.391 µM -0.585246950950122 0.267222002556323 no 2460 0.279190839634237 3365 677577
SGTC_2733 amorolfine 100 µM -0.586307112097886 0.266870174873331 no 2461 0.278834576260053 3486 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_1050 3232-1156 69.3 µM -0.586674582127043 0.26674828000828 no 2462 0.278711140918567 3421 700529
SGTC_3328 9140624 29.0385 µM -0.586998443516068 0.26664087406287 no 2463 0.278602376034005 3516 4904392
SGTC_1250 0485-0349 40.2 µM -0.588661010007735 0.266089842116193 no 2464 0.27804434908088 3436 6842794 YDL195W SEC31
SGTC_197 4544-0043 41.561 µM -0.589017006980046 0.265971927432835 no 2465 0.27792493250707 3484 896523
SGTC_833 3852-0053 558 µM -0.58936418775755 0.265856958385007 no 2466 0.277808497376309 3561 3123681
SGTC_2828 7998861 71.43 µM -0.589667400890302 0.265756569846651 no 2467 0.277706827303026 3454 2988188
SGTC_2129 girgensonine 121.053 µM -0.589749856891199 0.26572927343795 no 2468 0.277679182212297 3470 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_1157 4092-0394 27.6 µM -0.589824760660589 0.265704478368052 no 2469 0.27765407032964 3594 3659885
SGTC_1734 st037168 69.4 µM -0.590509474520654 0.26547787489442 no 2470 0.27742456784192 3448 708907
SGTC_2529 gangaleoidin 93.61 µM -0.592792318303432 0.264723085405765 no 2471 0.276660074625619 3495 4565183
SGTC_1255 0566-0045 221 µM -0.593707286005535 0.26442087111616 no 2472 0.276353954513954 3535 2788469
SGTC_2611 pyromycin 23.93 µM -0.594529957380151 0.264149292355679 no 2473 0.276078855853294 3449 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release.
SGTC_1100 amiodarone 5.07 µM -0.596147862022988 0.26361560744989 no 2474 0.275538226273818 3538 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death.
SGTC_802 4112-3352 742 µM -0.597065656446136 0.263313106885729 no 2475 0.275231773072228 3546 704594
SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM -0.597206607272374 0.263266665887908 no 2476 0.275184724206133 3378 4000243
SGTC_477 mead ethanolamide 10 µM -0.597694044277558 0.263106095601043 no 2477 0.275022050063247 3415 16061185
SGTC_680 0417-1641 114 µM -0.597702357075315 0.263103357653916 no 2478 0.27501927621359 3444 2835990
SGTC_2825 7998094 58.44 µM -0.598164670973721 0.262951110421391 no 2479 0.274865031049431 3462 2987815
SGTC_1825 st052143 62.6 µM -0.598980959053127 0.262682403934774 no 2480 0.274592791037861 3553 674173
SGTC_2309 7664088 163.95 µM -0.599821222461152 0.26240595203555 no 2481 0.274312694019358 3536 704922
SGTC_1703 st026983 48.3 µM -0.602363561530027 0.261570414853372 no 2482 0.273466079826537 3548 1104023
SGTC_3039 9090270 49.47 µM -0.602817209244228 0.261421467697857 no 2483 0.273315148519659 3540 17173750
SGTC_3092 9117248 49.47 µM -0.603522966260621 0.261189831559227 no 2484 0.273080420991913 3535 17141857
SGTC_3120 9124077 49.47 µM -0.603527307974208 0.261188406894186 no 2485 0.273078977291892 3535 18774327 YGL155W CDC43
SGTC_1555 citronellol 128 µM -0.604153732155509 0.260982897510131 no 2486 0.27287071932908 3515 8842 A terpine precursor.
SGTC_1085 doxorubicin 7.67 µM -0.604201044796716 0.260967379150308 no 2487 0.272854993196501 3542 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_2508 celastrol 40.54 µM -0.604879025793083 0.260745056184207 no 2488 0.27262969014622 3482 122724 Celastrol is a natural product and antioxidant.
SGTC_2441 5730946 39.09 µM -0.605320938683244 0.260600196957992 no 2489 0.272482885722662 3537 1774275
SGTC_688 0527-0193 473 µM -0.606356331054138 0.26026095723187 no 2490 0.272139079927522 3480 4007154
SGTC_1420 4'-methoxyflavone 42 µM -0.60650889415262 0.260210990145069 no 2491 0.272088439031058 3526 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13
SGTC_29 0299-0004 12.984 µM -0.607140771056918 0.260004092047181 no 2492 0.27187874743291 3445 16871 A napthoquinone isolated from Swertia calycina.
SGTC_728 3030-5151 22.5 µM -0.607421320131242 0.259912257892041 no 2493 0.271785671560469 3548 3125388
SGTC_2512 diallyl trisulfide 49.23 µM -0.607843689308063 0.259774032300348 no 2494 0.271645574903697 3534 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent
SGTC_3212 9128307 49.47 µM -0.60870780677204 0.259491357298286 no 2495 0.27135906575519 3351 27243542
SGTC_2234 tolnaftate 200 µM -0.610344405812491 0.258956419427882 no 2496 0.270816843505962 3491 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7
SGTC_1972 st070201 17.4 µM -0.6103965781442 0.25893937579465 no 2497 0.270799567169882 3533 2829099
SGTC_2136 5328288 199.296 µM -0.611000156855967 0.258742241176185 no 2498 0.270599738236643 3469 262395
SGTC_2580 diallyl disulphide 81.36 µM -0.611332132234636 0.258633847942545 no 2499 0.270489861381352 3498 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.
SGTC_3010 9080089 71.4286 µM -0.612848992877687 0.258138877283461 no 2500 0.269988096277246 3548 17027233
SGTC_1144 3486-0183 12.5 µM -0.613121374827356 0.258050047680729 no 2501 0.269898043910391 3503 6744069
SGTC_3185 9108267 49.47 µM -0.613973317894641 0.257772313123438 no 2502 0.269616479572012 3527 4910486
SGTC_2570 licareol 100 µM -0.614577506099886 0.257575441050575 no 2503 0.269416886617759 3489 443158
SGTC_936 3005-4620 401 µM -0.614920426959368 0.257463736542444 no 2504 0.269303636023916 3567 777207
SGTC_2213 7173844 200 µM -0.616542649673908 0.256935648099479 no 2505 0.26876821613995 3515 892728
SGTC_2574 2',4'-dihydroxychalcone 14.64 µM -0.61780727775942 0.2565243600824 no 2506 0.268351192749677 3586 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_1343 1487-0095 224 µM -0.618539433577827 0.25628640193164 no 2507 0.268109906095727 3549 4560101 YGL055W OLE1
SGTC_1274 0865-0114 173 µM -0.618563699363457 0.256278517272841 no 2508 0.268101911020096 3517 870624
SGTC_1767 st044992 70.3 µM -0.618966363126313 0.25614769857752 no 2509 0.267969259139312 3498 9600693
SGTC_2075 5212009 200 µM -0.619231292740959 0.25606164639102 no 2510 0.267881999854534 3502 780898
SGTC_32 0928-0142 34.1 µM -0.61929075461422 0.256042334562787 no 2511 0.267862416994793 3529 2244242
SGTC_2807 7945238 51.95 µM -0.620521317878199 0.255642846963471 no 2512 0.267457311723359 3549 17148797
SGTC_1829 berberine 14.4 µM -0.620803612802964 0.255551249225929 no 2513 0.267364422942407 3581 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_2760 etidronate 98.04 µM -0.622223755525613 0.255090708150222 no 2514 0.266897373819734 3534 3305 A chelator and antioxidant.
SGTC_1479 0549-0158 134 µM -0.622391936302765 0.255036197215613 no 2515 0.266842090712114 3576 5440202
SGTC_1965 Pectolinarigenin 58.4 µM -0.622421624343356 0.255026575328768 no 2516 0.266832332485762 3517 5320438 An anti-inflammatory.
SGTC_3041 9091929 49.47 µM -0.622500627282328 0.25500097142031 no 2517 0.266806365717051 3624 25236887
SGTC_2870 9038528 12.99 µM -0.622573776741591 0.254977265753859 no 2518 0.266782324014759 3554 6463316
SGTC_1215 3852-0577 11.2 µM -0.623672693341894 0.25462127685575 no 2519 0.266421279876458 3607 2884876
SGTC_1872 amphotericin b 148 nM -0.625523070715681 0.254022444469436 no 2520 0.265813905718858 3538 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1
SGTC_1924 st058459 75.1 µM -0.625617807273188 0.253991805042013 no 2521 0.265782827965407 3535 688683
SGTC_2745 rifampicin 24.3 µM -0.625802428385976 0.253932100979948 no 2522 0.265722269420827 3478 25141428 Inhibits bacterial DNA-dependent RNA polymerase.
SGTC_1480 1070-0044 41.2 µM -0.625991818179975 0.253870862442228 no 2523 0.265660153945701 3544 3124987
SGTC_1728 st035614 33.7865 µM -0.627025315307879 0.253536821320548 no 2524 0.265321320543458 3497 15945546
SGTC_1186 1319-0216 26 µM -0.627094049006241 0.253514613793951 no 2525 0.26529879389154 3609 4565136
SGTC_1188 1403-0014 4.57 µM -0.627830244542059 0.253276816677754 no 2526 0.265057575469779 3573 9614867
SGTC_845 0330-0138 4.51 µM -0.627895843519775 0.253255633368971 no 2527 0.265036087019856 3535 9039800
SGTC_751 0833-0568 350 µM -0.628204037470498 0.253156123440827 no 2528 0.26493514286967 3559 6954252
SGTC_3247 9135149 49.47 µM -0.62933633285987 0.252790703570952 no 2529 0.264564444900781 3538 8934436 YOR116C RPO31
SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM -0.629863736746231 0.252620592075287 no 2530 0.264391870232799 3583 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_1898 st060199 18.6 µM -0.630038019727128 0.252564391226355 no 2531 0.264334854758113 3563 688866
SGTC_3354 9151612 71.43 µM -0.630205974131775 0.252510237379911 no 2532 0.264279915556848 3557 27261949
SGTC_2300 7976697 71.57 µM -0.630862832415913 0.252298504127589 no 2533 0.264065107916228 3480 2236109
SGTC_1441 4106-0040 13 µM -0.631925998941562 0.251955998978406 no 2534 0.263717616832349 3574 2904180
SGTC_3186 9110464 49.47 µM -0.632138331562023 0.251887624224378 no 2535 0.263648244844947 3586 17018021
SGTC_1673 st016611 27.3 µM -0.632767151916534 0.251685190725739 no 2536 0.263442855210167 3585 5226799
SGTC_1904 st060225 78 µM -0.633309773869783 0.251510575803102 no 2537 0.263265685963696 3561 66595
SGTC_2871 9038510 12.99 µM -0.633471272167738 0.251458618259163 no 2538 0.263212967576784 3602 4945164
SGTC_269 exalamide 29 µM -0.633673953415095 0.251393419284659 no 2539 0.263146813344222 3527 3316 A derivative of salicylamide.
SGTC_675 1309-0189 238 µM -0.633836037158483 0.25134128624026 no 2540 0.263093916064988 3518 4246530
SGTC_2360 9040895 200 µM -0.634730416063871 0.251053718650487 no 2541 0.262802126358951 3507 4914414
SGTC_700 3453-2283 142 µM -0.636825502353262 0.250380772452577 no 2542 0.262119256313759 3632 565664
SGTC_2104 5389443 200 µM -0.636961010209598 0.250337279984459 no 2543 0.262075120366748 3621 2244536
SGTC_2068 5226020 147 µM -0.637450827852605 0.250180102005718 no 2544 0.261915614782282 3563 1810509
SGTC_3061 glucosamine 200 µM -0.637626028937561 0.250123894299654 no 2545 0.261858573901734 3533 91431 and experimental redox chemotherapeutic
SGTC_160 3453-0671 289.699 µM -0.639333695623148 0.249576394673517 no 2546 0.261302936273548 3533 5322268
SGTC_1606 st000094 49.2 µM -0.640727547194791 0.249129980528064 no 2547 0.260849856627145 3622 1242210
SGTC_2181 6316240 54.2555 µM -0.643751795357727 0.248162855445607 no 2548 0.259868198465412 3563 12779990
SGTC_929 2805-0021 398 µM -0.643941797326064 0.248102161592134 no 2549 0.259806588320376 3581 3098024
SGTC_1247 0448-0043 5.84 µM -0.646799714698541 0.247190190197559 no 2550 0.258880788523704 3600 3089013 YGL099W LSG1
SGTC_2591 skatole 100 µM -0.647027698641246 0.247117517013667 no 2551 0.258807008501483 3601 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite.
SGTC_653 0203-0016 55.2 µM -0.650972330651222 0.2458619199085 no 2552 0.257532174147314 3584 295302
SGTC_3266 9136860 49.47 µM -0.652112037929725 0.245499783716471 no 2553 0.257164449446766 3529 4871271 YPR165W RHO1
SGTC_2989 9073649 71.4286 µM -0.65284081689573 0.245268368205117 no 2554 0.256929453281894 3600 21367202
SGTC_995 3931-2021 34.6 µM -0.653903086678826 0.244931266614396 no 2555 0.256587122595648 3579 730143
SGTC_1282 0886-0010 32.4 µM -0.654839512817901 0.244634307232566 no 2556 0.256285543839465 3658 2836211 YNL267W PIK1
SGTC_2630 antimycin a 100 µM -0.656572682602111 0.244085196485381 no 2557 0.255727859329395 3603 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain.
SGTC_2380 9035439 200 µM -0.657182070966318 0.243892285360027 no 2558 0.25553192622704 3671 6462575
SGTC_1385 3091-4834 14.1 µM -0.657668602738365 0.243738325435732 no 2559 0.255375550810687 3581 4072814
SGTC_1027 k015-0025 8.67 µM -0.657679465552456 0.243734888565309 no 2560 0.255372059981475 3600 3598955
SGTC_2182 6325192 200 µM -0.658694426654836 0.243413881903024 no 2561 0.255046006317115 3569 736248
SGTC_168 3970-0862 530.542 µM -0.660022623413842 0.242994151975061 no 2562 0.254619655690911 3626 3135186
SGTC_333 3486-0131 40.1 µM -0.660466243902188 0.242854048571486 no 2563 0.254477336900104 3681 6744690
SGTC_2900 5328528 85.29 µM -0.662897261444002 0.242087065790952 no 2564 0.253698177888609 3632 795359
SGTC_2684 capsaicin 100 µM -0.664536612277315 0.241570595245072 no 2565 0.253173462012823 3630 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_427 1354-0053 47.3 µM -0.664705064372189 0.241517559043803 no 2566 0.253119576996837 3668 6813657
SGTC_2211 7117706 200 µM -0.665500910960502 0.241267076722228 no 2567 0.252865080543777 3577 822771
SGTC_1596 piperlongumine 63 µM -0.667941079833369 0.240499946231996 no 2568 0.252085601805352 3641 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_1893 st059353 36.1 µM -0.671432194078279 0.239404737221313 no 2569 0.25097262075768 3601 3112488
SGTC_1724 st037281 8.293 µM -0.674304108335184 0.23850582544925 no 2570 0.250058996327456 3644 574124 YDL195W SEC31
SGTC_387 norethindrone acetate 66.7 µM -0.674623788297453 0.238405879742152 no 2571 0.249957407757019 3628 541197
SGTC_1326 1431-2094 10.8 µM -0.674684734557476 0.23838682792299 no 2572 0.249938042612553 3616 616278
SGTC_1278 0874-0585 172 µM -0.67568552776698 0.238074098948996 no 2573 0.249620163189693 3644 766306
SGTC_2011 4012611 177 µM -0.676158337236275 0.23792643316269 no 2574 0.249470060639819 3652 2049887
SGTC_1738 st035555 74 µM -0.676516764700431 0.237814524136335 no 2575 0.249356302850783 3650 5331140
SGTC_447 ml7 120 µM -0.678003206388495 0.237350732231312 no 2576 0.248884830109828 3669 4216 Selective myosin light chain kinase inhibitor.
SGTC_432 NS 1619 61.3 µM -0.678405250794282 0.23722537378911 no 2577 0.248757390383264 3644 4552 A K+/calcium channel activator.
SGTC_611 3453-1652 23.7 µM -0.679808511515758 0.236788118742322 no 2578 0.248312858296375 3641 1560575
SGTC_1761 st044296 37 µM -0.68128043073304 0.236329946428909 no 2579 0.247847031702856 3658 1826700
SGTC_1636 st007707 68.9 µM -0.682682450200313 0.235893986472872 no 2580 0.247403760830468 3671 403051
SGTC_1336 1486-0901 104 µM -0.682716032074138 0.235883549580226 no 2581 0.247393148582616 3668 5006114
SGTC_1379 2144-0755 36.5 µM -0.683294084396582 0.235703936913152 no 2582 0.247210515725492 3675 5392327
SGTC_919 tnp00227 403.569 nM -0.684045643667405 0.235470524915276 no 2583 0.246973172028504 3660 1269246 A methoxyflavone. YNL221C POP1
SGTC_3156 9099931 49.47 µM -0.684091156999686 0.235456393922568 no 2584 0.24695880275735 3671 18111053
SGTC_1467 k284-1082 293 µM -0.684295006663636 0.235393108361594 no 2585 0.246894449718288 3635 3334705
SGTC_3060 1327-0027 12.5 µM -0.685501069401694 0.235018875775918 no 2586 0.246513893021997 3578 16000455 YPR107C YTH1
SGTC_620 0109-0052 432 µM -0.686015487194605 0.234859355692005 no 2587 0.246351671144103 3652 493037
SGTC_2676 harmalol 100 µM -0.686282108889231 0.23477670030944 no 2588 0.246267614394745 3655 5459187 A monoamine oxidase inhibitor
SGTC_2669 eugenol 100 µM -0.686786252907145 0.234620454599913 no 2589 0.246108716973041 3625 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism.
SGTC_2747 doxorubicin 7.63 µM -0.686811335346268 0.234612682482962 no 2590 0.246100812860968 3549 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_3075 9116269 49.47 µM -0.687716880768639 0.234332182952182 no 2591 0.245815543770906 3665 17015205 YNL244C SUI1
SGTC_448 monastrol 171 µM -0.688632812408951 0.234048655125766 no 2592 0.245527183432796 3599 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity
SGTC_2765 myclobutanil 7.74 µM -0.688725179373993 0.234020073362341 no 2593 0.245498113875648 3674 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11
SGTC_2076 5212012 200 µM -0.688965639301265 0.233945675214556 no 2594 0.245422445454188 3561 604802
SGTC_612 0302-0167 22.4 µM -0.689823377970629 0.233680398183393 no 2595 0.245152632615558 3683 235821
SGTC_317 4495-0002 170 µM -0.690064504581902 0.233605853818266 no 2596 0.245076811843107 3641 15991618
SGTC_304 1310-0298 97 µM -0.690773536672435 0.233386732742585 no 2597 0.244853934178661 3605 1550234
SGTC_2993 9054257 71.4286 µM -0.691466301865866 0.233172749013811 no 2598 0.244636275269519 3665 6470217 YGL055W OLE1
SGTC_865 0488-0499 301 µM -0.691723350898483 0.233093378523566 no 2599 0.244555539911687 3668 9634651
SGTC_3209 9113616 49.47 µM -0.692906556139835 0.232728227028397 no 2600 0.244184097520915 3687 16649353
SGTC_915 methyl methanesulfonate (MMS) 110 mM -0.693755109649012 0.232466548989257 no 2601 0.243917899419106 3697 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks.
SGTC_3055 9094636 49.47 µM -0.693870397042675 0.232431009142336 no 2602 0.243881744916858 3690 25236176
SGTC_2646 retinol 96.75 µM -0.695646813486952 0.231883772314478 no 2603 0.243325020686382 3676 445354 A vitamin A analog and teratogen.
SGTC_25 0118-0223 35.662 µM -0.696509291183813 0.231618339358288 no 2604 0.243054970339052 3696 5333628
SGTC_3081 9117243 49.47 µM -0.696911010546905 0.231494765517358 no 2605 0.242929243364251 3691 45595589
SGTC_2892 9047358 58.44 µM -0.696959099547818 0.231479975210135 no 2606 0.242914195204455 3660 6466771
SGTC_2291 7917025 104.35 µM -0.69753076409024 0.231304193783409 no 2607 0.242735346795915 3637 2964612
SGTC_1394 3474-0001 65.7 µM -0.699987495333311 0.230549620374923 no 2608 0.241967556871521 3647 5017666 YIL048W NEO1
SGTC_960 1222-0186 7.7 µM -0.701110435417096 0.230205173278794 no 2609 0.241617049193129 3683 3126296
SGTC_2041 5107442 45.335 µM -0.701234920748027 0.230167006773132 no 2610 0.241578210080772 3676 793005
SGTC_1058 3448-5425 97.3 µM -0.703060682471281 0.229607645293326 no 2611 0.241008966635463 3608 7279705
SGTC_3272 9137413 49.47 µM -0.703439299646713 0.2294917431653 no 2612 0.240891011211249 3638 17614870
SGTC_2292 7671323 168.05 µM -0.704091348576922 0.229292215095338 no 2613 0.240687943749527 3677 937504
SGTC_1402 3909-7673 35.9 µM -0.706128044856018 0.228669609375084 no 2614 0.240054256306546 3681 5328014
SGTC_712 r015-0009 80.6 µM -0.707053576770666 0.22838699389536 no 2615 0.239766591833431 3684 6813872 YLR060W FRS1
SGTC_3233 9132340 49.47 µM -0.708329021815925 0.227997852622545 no 2616 0.239370479279803 3678 17682950
SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM -0.709949938322542 0.227503845801818 no 2617 0.238867590503813 3751 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_3308 9128332 17.569 µM -0.710633682978873 0.22729564181446 no 2618 0.238655632371205 3683 17332805 YDL196W YDL196W
SGTC_1051 3253-3903 78 µM -0.710696631483516 0.227276479049351 no 2619 0.238636123759589 3690 5509239
SGTC_1624 st003710 6.25 µM -0.712214881193775 0.226814569787892 no 2620 0.238165861651197 3705 24207033
SGTC_1412 3909-8563 178 µM -0.713724442684976 0.226355829359509 no 2621 0.237698794502289 3768 23767530
SGTC_1935 st074532 41.6 µM -0.713780840068313 0.226338700927597 no 2622 0.23768135456517 3741 2829742
SGTC_2250 alverine citrate 130 µM -0.716001719915478 0.225664780507083 no 2623 0.236995143456404 3644 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1
SGTC_1093 fluphenazine 7.97 µM -0.716062343345163 0.225646400411528 no 2624 0.23697642720925 3734 6602611 An atypical antipsychotic.
SGTC_3128 9127691 49.47 µM -0.716341992744173 0.225561625962555 no 2625 0.236890101680822 3681 41316314
SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM -0.71642287236884 0.225537111031389 no 2626 0.236865138012371 3744 6708784 An antioxidant flavonoid
SGTC_367 0335-0881 7.1 µM -0.717160573601284 0.225313580511339 no 2627 0.236637511728744 3677 23828853
SGTC_184 1494-0393 24.714 µM -0.717730889044 0.225140855504635 no 2628 0.236461616788293 3692 3090647
SGTC_1803 st050068 52.4 µM -0.71782023989593 0.225113801618192 no 2629 0.236434065994101 3791 3984059 YIL048W | YNL267W NEO1 | PIK1
SGTC_1465 k213-0056 144 µM -0.719588662146356 0.224578733181428 no 2630 0.23588914740596 3613 24048857 YMR208W ERG12
SGTC_2769 toremifene 3.73 µM -0.722855669618795 0.223592140629062 no 2631 0.234884280634528 3725 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_994 3910-0338 138 µM -0.725501651621769 0.222794899278667 no 2632 0.234072166000694 3797 3479481
SGTC_881 0833-0569 170 µM -0.725669354689892 0.222744424547175 no 2633 0.234020746408598 3728 5418700
SGTC_1693 xanthone 101.9 µM -0.726545147306839 0.222480937200751 no 2634 0.233752320506513 3779 7020 An insecticide.
SGTC_431 k089-0097 107 µM -0.727864556998408 0.22208432084804 no 2635 0.233348250681863 3680 5499420
SGTC_1445 4239-0156 97.7 µM -0.728806392968137 0.221801450723698 no 2636 0.233060050216871 3785 4008346
SGTC_1193 1488-0126 41.5 µM -0.72892216148597 0.221766695125702 no 2637 0.233024638860835 3737 1384710
SGTC_1876 myriocin 605 nM -0.729407831316396 0.221620923026629 no 2638 0.23287611439497 3737 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1
SGTC_459 nigericin 15.3 µM -0.729985849450109 0.221447504295548 no 2639 0.232699417119148 3756 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification.
SGTC_99 0109-0120 622.8 µM -0.730131551954659 0.221403802440102 no 2640 0.232654888348309 3762 759414
SGTC_3223 9129970 49.47 µM -0.732061259611294 0.220825473297854 no 2641 0.232065589042132 3771 17248386
SGTC_3190 9110366 49.47 µM -0.732080809521346 0.220819618662224 no 2642 0.232059623093043 3668 17123768
SGTC_1634 st006576 41 µM -0.73270988679773 0.220631275565537 no 2643 0.231867696285001 3701 3915356
SGTC_1928 4'-methoxychalcone 40.3 µM -0.734081560354794 0.220220921510883 no 2644 0.231449515585448 3751 641818
SGTC_2362 9071156 126 µM -0.734655738855881 0.220049278545636 no 2645 0.231274591316886 3730 653133
SGTC_625 k213-0058 121 µM -0.735019502706643 0.219940575943946 no 2646 0.231163808332139 3793 3655420
SGTC_2575 plumbagin 510 nM -0.736908383946917 0.219376622148729 no 2647 0.230589032600867 3685 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_2762 leflunomide 42.06 µM -0.737130002562668 0.219310509098527 no 2648 0.230521647712964 3716 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1
SGTC_1765 st044815 90.4 µM -0.739044044440145 0.218739990697033 no 2649 0.22994012640086 3755 645695
SGTC_3355 9151058 44.0485 µM -0.739621214430809 0.218568121417215 no 2650 0.229764932752122 3746 17015728
SGTC_2165 5727197 32.143 µM -0.739988569750517 0.218458771107971 no 2651 0.22965346499466 3826 1361712
SGTC_495 decylubiquinone 155 µM -0.741272291829409 0.218076894286389 no 2652 0.22926417921357 3726 2971 A Co-enzyme Q analog. A free radical scavenger.
SGTC_920 mycophenolic acid 780.421 nM -0.742577888182262 0.217688905362439 no 2653 0.228868639891476 3771 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_201 4262-0159 12.803 µM -0.743418817558628 0.217439214271715 no 2654 0.228614077525715 3741 1341029
SGTC_2005 4024620 188 µM -0.744430927531642 0.2171389151286 no 2655 0.228307907112562 3740 236743
SGTC_674 0498-0004 451 µM -0.745452630090799 0.216836012973403 no 2656 0.227999068759451 3751 4231473
SGTC_2090 5301565 104.445 µM -0.749187985682705 0.215730680817337 no 2657 0.226871954731545 3766 2056344
SGTC_2704 st078022 71.1 µM -0.750259082480256 0.215414335286834 no 2658 0.22654934052448 3766 54697681
SGTC_2452 5863136 48.41 µM -0.751924649579655 0.214922949552994 no 2659 0.226048186811948 3728 2184096
SGTC_1081 sertraline 6 µM -0.752969571810119 0.214615002867849 no 2660 0.225734099547082 3756 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1
SGTC_2885 9057732 51.95 µM -0.753020728003089 0.214599933329078 no 2661 0.225718729137911 3770 6471414
SGTC_644 1498-1197 63.3 µM -0.755295982704916 0.21393031338783 no 2662 0.225035704287394 3824 6741615
SGTC_563 tetrahydrosecaminediol 614 µM -0.755557390727794 0.21385345755723 no 2663 0.224957305440541 3810 334274 A psychoactive constituent of the cannabis plant.
SGTC_2215 7188065 200 µM -0.755607830406874 0.213838629781027 no 2664 0.224942179864709 3749 940217
SGTC_1837 st055472 66.5 µM -0.755609523956853 0.213838131937731 no 2665 0.224941672022181 3829 676091
SGTC_177 1327-0068 8.361 µM -0.757205603574907 0.213369241580741 no 2666 0.224463346799706 3754 15389900 YOR207C | YLR033W RET1 | RSC58
SGTC_1735 st034310 56.75 µM -0.75791955589028 0.213159693485038 no 2667 0.224249571149505 3891 871153
SGTC_352 k048-0007 5.11 µM -0.758615520895803 0.212955540322025 no 2668 0.224041292674175 3787 6811911
SGTC_162 k030-0015 37.8 µM -0.759881565519686 0.212584453700792 no 2669 0.223662690828659 3832 1809920 YMR134W ERG29
SGTC_2149 5554786 194.827 µM -0.760021351478328 0.212543504613177 no 2670 0.223620911121681 3804 745063 YPR165W RHO1
SGTC_2680 butyl paraben 22.24 µM -0.76027727778393 0.212468545155965 no 2671 0.223544430491412 3811 7184 An antifungal and steroid mimetic.
SGTC_742 0kpi-0133 140 µM -0.761870077929045 0.212002369737134 no 2672 0.223068775066612 3803 2728852
SGTC_803 4488-1585 147 µM -0.763365024671437 0.211565378417682 no 2673 0.222622866231999 3799 747204
SGTC_2348 9022543 33.42 µM -0.763771488298455 0.211446655345843 no 2674 0.222501715235893 3799 3162678 YDL140C RPO21
SGTC_103 0844-0104 51.839 µM -0.767661581631078 0.210312381512209 no 2675 0.221344133116082 3774 5375804
SGTC_597 k018-0003 82.8 µM -0.76808183566078 0.210190057996752 no 2676 0.221219283824274 3871 6786234
SGTC_3102 9121669 49.47 µM -0.768662462303675 0.210021123526112 no 2677 0.221046857244655 3796 41905072
SGTC_2283 7944793 200 µM -0.76906966947025 0.209902693405087 no 2678 0.220925976314226 3814 2970533
SGTC_2155 5570423 76 µM -0.769156229309477 0.209877523828445 no 2679 0.220900285588504 3742 797402
SGTC_2175 5807670 165.306 µM -0.769499011989233 0.20977786806647 no 2680 0.220798565416603 3741 241186
SGTC_2133 5320837 200 µM -0.771208819201037 0.209281198656689 no 2681 0.220291583801331 3770 2841355
SGTC_935 2996-0153 430 µM -0.772398056465707 0.208936154297273 no 2682 0.219939352313198 3759 23738523
SGTC_565 1418-0001 44.5 µM -0.774383047083941 0.208360977750933 no 2683 0.219352152948835 3832 2862145
SGTC_3322 9139058 2.11 µM -0.774596108627871 0.2082992959835 no 2684 0.219289178726363 3904 4908926 YPR165W RHO1
SGTC_2565 isoliquiritigenin 100 µM -0.774928248831069 0.208203162180787 no 2685 0.219191029363747 3851 638278 Binds to benzodiazepine receptor 65X better than valium.
SGTC_780 0109-0199 192 µM -0.775935222636854 0.20791186633242 no 2686 0.218893617138041 3816 610414
SGTC_1534 6-azauridine 81.6 µM -0.777424668352917 0.207481443247286 no 2687 0.218454131566055 3822 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1
SGTC_2790 5423970 71.43 µM -0.777716103740604 0.207397285300293 no 2688 0.218368198220901 3853 1376240 YKL165C | YIL048W MCD4 | NEO1
SGTC_2534 helenine 20.12 µM -0.7786264811785 0.207134525149518 no 2689 0.218099887570259 3802 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58
SGTC_699 0375-0592 111 µM -0.779419062108182 0.206905924765512 no 2690 0.217866449262139 3818 762578
SGTC_120 rhodamine 6G 52.259 µM -0.780614282661165 0.206561475441723 no 2691 0.217514694424349 3838 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase
SGTC_2705 st078069 42.8 µM -0.781260991928579 0.20637524268836 no 2692 0.217324503867187 3833 1530061
SGTC_1013 4112-3890 241 µM -0.781620409481841 0.206271784307045 no 2693 0.217218844384685 3762 705171
SGTC_1508 1080-0625 72.9 µM -0.781953442296868 0.206175948219802 no 2694 0.217120967824478 3713 767111
SGTC_737 1950-0117 57.9 µM -0.783650322826052 0.205688050870602 no 2695 0.216622659561126 3750 5393513
SGTC_2744 captopril 92.04 µM -0.78688958391519 0.20475858376279 no 2696 0.215673252756645 3755 44093 angiotensin-converting enzyme (ACE) inhibitor
SGTC_1101 ebselen 5.29 µM -0.787034988250286 0.204716920401938 no 2697 0.215630692323332 3826 3194 A potent scavenger of hydrogen peroxide and hydroperoxides.
SGTC_2318 6029776 164 µM -0.787274115396087 0.204648413187642 no 2698 0.215560709437577 3789 818325
SGTC_36 0335-0881 14.2 µM -0.787659704289304 0.204537975076646 no 2699 0.215447890844715 3752 23828853
SGTC_3161 9100388 49.47 µM -0.788034643806798 0.204430621114428 no 2700 0.215338220981885 3824 25236368
SGTC_2845 9003024 42.97 µM -0.788110243310063 0.204408979270316 no 2701 0.21531611204101 3835 2990173
SGTC_1828 st055811 49 µM -0.788870613959329 0.204191384072032 no 2702 0.215093816249224 3832 5877589
SGTC_1694 st024011 44.9 µM -0.790494829868232 0.203727044661114 no 2703 0.21461942021623 3847 2787533
SGTC_1377 2944-0135 198 µM -0.791511396904372 0.203436743690167 no 2704 0.214322814095182 3872 1894137
SGTC_1788 fluconazole 20 µM -0.791921031246108 0.203319834234668 no 2705 0.214203361560314 3872 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11
SGTC_1760 st045453 10.4495 µM -0.793119106257061 0.202978134348286 no 2706 0.213854216037864 3881 3323419 YIL048W NEO1
SGTC_192 3455-0609 60.9 µM -0.793420627067118 0.202892192421834 no 2707 0.213766398435746 3891 3769639
SGTC_150 3970-0969 77.2 µM -0.793611583364736 0.202837775739874 no 2708 0.213710793489687 3915 6615640
SGTC_57 miconazole 162.5 nM -0.793975333707695 0.202734142186114 no 2709 0.213604895613378 3742 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_584 0986-0246 15.4 µM -0.79607099444435 0.2021376986837 no 2710 0.21299538604117 3913 53315 YDR232W HEM1
SGTC_1006 4099-6547 255 µM -0.797431744617699 0.201750980018368 no 2711 0.212600164492292 3877 3146833
SGTC_16 erodoxin 22.806 µM -0.798376202892518 0.201482830181952 no 2712 0.212326104348118 3851 3967339 Erodoxin inhibits Ero1. YML130C ERO1
SGTC_2919 7978188 46.38 µM -0.800978743864537 0.200745024733302 no 2713 0.211571975772597 3784 2980291
SGTC_1516 st013856 110 µM -0.801357162351272 0.20063788046523 no 2714 0.211462453589828 3902 5281404 A mutagen and neurotoxin.
SGTC_328 k915-0120 63.5 µM -0.801810508240819 0.200509566692032 no 2715 0.211331289579358 3833 6624543
SGTC_1160 4092-0570 10.5 µM -0.803735734952117 0.199965205080938 no 2716 0.210774805767329 3825 4994975
SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM -0.803872142058886 0.199926669446081 no 2717 0.210735410136117 3747 1241132 A phosphatase inhibitor.
SGTC_1311 1190-0148 100 µM -0.803971032676495 0.199898735184392 no 2718 0.210706852314119 3895 1961333
SGTC_1560 lithocholic acid 53.1 µM -0.80750989697414 0.198900635305289 no 2719 0.209686387431008 3730 9903 A bile acid which acts as a detergent.
SGTC_75 0159-0059 199.013 µM -0.808612641420354 0.19859023257471 no 2720 0.209368995544792 3877 5377270
SGTC_664 1222-0054 14.9 µM -0.810817089377479 0.197970596592056 no 2721 0.208735359509732 3802 6813991
SGTC_246 cycloheximide 667 µM -0.810980309155485 0.197924764532279 no 2722 0.208688489372487 3723 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells.
SGTC_343 4130-2827 29.8 µM -0.81279970482204 0.197414312855238 no 2723 0.208166452406393 3910 1118244
SGTC_2302 7771753 200 µM -0.813079282627079 0.197335944820899 no 2724 0.208086301853156 3868 2203047
SGTC_822 1487-0950 154 µM -0.815651445292537 0.196615829026186 no 2725 0.207349758403435 3841 1958375
SGTC_3124 9127567 49.47 µM -0.81586553783049 0.196555962438886 no 2726 0.207288522183113 3798 17592030
SGTC_1640 st009078 66.4 µM -0.816203550078756 0.196461466732603 no 2727 0.207191863367904 3819 690618
SGTC_1202 1988-0068 29.6 µM -0.816553858345999 0.196363562571754 no 2728 0.207091716488627 3822 2850480
SGTC_3231 9132313 49.47 µM -0.816925133589157 0.196259830848052 no 2729 0.206985606790647 3844 4905967
SGTC_2986 9022445 71.43 µM -0.816997170914643 0.196239707968877 no 2730 0.206965022399057 3815 6459286
SGTC_1143 3454-2408 5.08 µM -0.818610731060933 0.195789304579364 no 2731 0.206504271260591 3782 X1143
SGTC_544 k015-0020 52.4 µM -0.824103048020042 0.194260907470205 no 2732 0.204940504209128 3873 3008304
SGTC_2896 9052656 71.43 µM -0.826362808325683 0.193634178848595 no 2733 0.204299157157088 3803 6469436
SGTC_359 0081-0058 15.9 µM -0.827451097296853 0.193332789960401 no 2734 0.203990714519121 3866 3494159
SGTC_730 1436-0052 41.2 µM -0.827997385668388 0.193181609762831 no 2735 0.20383599023169 3888 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2
SGTC_2427 5545055 42.75 µM -0.829480881306301 0.192771430424605 no 2736 0.203416175431662 3847 5372858
SGTC_2841 9004761 38.96 µM -0.832438431520423 0.191955271561708 no 2737 0.202580758472106 3898 2991039
SGTC_830 4076-0286 57.8 µM -0.833575911742525 0.191641939053557 no 2738 0.202260002141621 3943 6866659
SGTC_1489 4065-0444 182 µM -0.836559022983544 0.19082169467494 no 2739 0.201420243438379 3830 2877968
SGTC_45 0kpi-0036 14.9 µM -0.837236659365159 0.190635670602577 no 2740 0.201229777515403 3913 2795021
SGTC_1923 st058458 19.1 µM -0.83805458007079 0.19041128414031 no 2741 0.201000025217857 3885 3534982
SGTC_309 k408-0051 1.48 µM -0.838201947840235 0.190370872860839 no 2742 0.200958646641464 3843 3640463
SGTC_180 1486-1293 102.781 µM -0.838822080467123 0.190200877442399 no 2743 0.200784579058333 3814 4140536
SGTC_2099 5377090 177.372 µM -0.839974817111349 0.18988512852222 no 2744 0.200461253202093 3926 2243829
SGTC_1727 st034309 9.9045 µM -0.842568902823924 0.189175755682162 no 2745 0.199734794511445 4020 870305
SGTC_2782 7736369 71.43 µM -0.843110736255838 0.189027793411001 no 2746 0.199583257390819 3947 2950836 YOL077C BRX1
SGTC_1690 st023502 41.2 µM -0.843309187032295 0.188973618900119 no 2747 0.199527773038631 3863 24207482
SGTC_2153 5569715 200 µM -0.844301366302791 0.188702910190218 no 2748 0.199250511404015 3910 2054701
SGTC_917 harmaline 728.087 nM -0.847974343418391 0.187702847767287 no 2749 0.198226129706347 3903 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7
SGTC_1229 0139-0193 12.2 µM -0.851342031176576 0.186788791077711 no 2750 0.197289691552105 3944 3090752
SGTC_1090 efavirenz 20.7 µM -0.851751167193715 0.186677931505616 no 2751 0.197176107476085 3946 64139 A non-nucleoside reverse transcriptase inhibitor.
SGTC_1861 st057647 17.4 µM -0.852846869494766 0.18638124047702 no 2752 0.196872114239751 3996 688668
SGTC_23 0213-0011 39.996 µM -0.853880726546408 0.186101563726759 no 2753 0.196585539788717 3907 627608
SGTC_1341 1486-1360 280 µM -0.85437050703851 0.185969160236368 no 2754 0.196449865986051 3882 3976547
SGTC_629 3448-6466 76.7 µM -0.854621967725451 0.185901204985743 no 2755 0.196380231062322 3894 573744
SGTC_28 pentachloropyridine N-oxide 1.606 µM -0.855436763992516 0.185681118579019 no 2756 0.196154699085259 3851 140250 A respiratory chain inhibitor.
SGTC_1302 1159-0335 255 µM -0.855630840310699 0.185628720046465 no 2757 0.196101002796019 3924 649284
SGTC_2470 5664817 21.68 µM -0.855891922322049 0.185558245167419 no 2758 0.196028781694149 3928 2859561
SGTC_1939 st074455 53.6 µM -0.856087859763212 0.185505365922702 no 2759 0.195974591631259 3893 1644229
SGTC_65 0798-0905 34.986 µM -0.856441348498511 0.185409990677244 no 2760 0.195876850882954 3958 3602145
SGTC_2237 6667747 47.222 µM -0.857320332129797 0.185172962970715 no 2761 0.195633937399074 3905 729940 YDL015C TSC13
SGTC_2176 5809774 33.9695 µM -0.857808441471132 0.185041420170302 no 2762 0.195499123868815 3901 2870539
SGTC_2511 berberine 10.47 µM -0.858625655741936 0.184821315391084 no 2763 0.195273539431424 3907 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_2482 5981709 142.65 µM -0.858802384043932 0.184773737602682 no 2764 0.195224776027169 3902 877755
SGTC_2277 7947813 106.88 µM -0.859774094327967 0.184512275320424 no 2765 0.194956791025281 4011 1246798
SGTC_3349 9149703 23.001 µM -0.861832004636673 0.183959304691617 no 2766 0.19438998518611 3906 4910494
SGTC_259 usnic acid 108.925 µM -0.862793952065785 0.183701178978747 no 2767 0.194125382494958 3991 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_3334 9142812 21.919 µM -0.864086607114754 0.183354667864149 no 2768 0.193770157829207 3959 45283678
SGTC_80 0159-0065 512.242 µM -0.865212828667608 0.183053103600157 no 2769 0.193460992729815 3815 1548079
SGTC_1257 0669-0121 16 µM -0.86651428782798 0.18270500224888 no 2770 0.1931040972578 3942 4307855
SGTC_199 4063-0024 41.6 µM -0.867384222447 0.182472551409002 no 2771 0.192865761837201 3934 306215
SGTC_1866 st057638 64 µM -0.868500962318729 0.18217442390512 no 2772 0.192560072859316 3902 688802
SGTC_931 2812-0076 566 µM -0.868685018430057 0.182125317093248 no 2773 0.19250971900136 3916 3450959
SGTC_356 1634-0012 32.5 µM -0.868778816185284 0.182100294708598 no 2774 0.192484061016626 3906 735457
SGTC_1550 gossypolone 36.6 µM -0.870836169413452 0.18155199616766 no 2775 0.191921806580045 3933 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_2800 7887935 81.82 µM -0.871035121944681 0.181499028819718 no 2776 0.191867488166523 3971 2961002
SGTC_3353 9151644 39.2805 µM -0.871233887295971 0.181446120965061 no 2777 0.191813230256234 3993 4909158
SGTC_248 streptozotocin 5.23457 mM -0.872996753399458 0.180977299523763 no 2778 0.19133242366058 3935 5300 DNA alkylating agent.
SGTC_1889 st059080 5.18 µM -0.875010407969089 0.180442712347463 no 2779 0.19078412132539 3870 176925 Isolated from Daphnopsis sellowiana.
SGTC_2358 9037157 4 µM -0.875770587115277 0.180241157014378 no 2780 0.190577381457992 3940 2388925
SGTC_176 1486-1328 72.834 µM -0.878289484733032 0.179574302068022 no 2781 0.189893320389307 4013 22310231
SGTC_2186 6124449 200 µM -0.879703730672761 0.179200574065233 no 2782 0.189509913924244 3948 3834182 YLR033W RSC58
SGTC_606 k015-0008 38.6 µM -0.880659579543015 0.178948259133768 no 2783 0.18925105029364 4007 1970475
SGTC_1106 tegaserod maleate 11.7 µM -0.883820246907596 0.178115532296158 no 2784 0.188396627438399 3949 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation.
SGTC_598 3937-0236 20.2 µM -0.884365328851428 0.177972169362991 no 2785 0.188249516413325 4018 1379313
SGTC_1167 k781-0610 148 µM -0.88560645839235 0.177646009316579 no 2786 0.187914815076942 3970 4525169
SGTC_3141 9094609 49.47 µM -0.886544883299601 0.177399648476956 no 2787 0.187661989646854 3912 25236309 YDL196W YDL196W
SGTC_2420 aureobasidin a 50 nM -0.886925817972913 0.177299704840868 no 2788 0.187559420253917 4097 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1
SGTC_1091 telmisartan 47.6 µM -0.887931100218053 0.177036125494106 no 2789 0.187288907175858 4015 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension.
SGTC_2349 9023730 187.07 µM -0.890092323001036 0.176470303808266 no 2790 0.186708157416063 3976 4126287
SGTC_1334 1486-0610 236 µM -0.893069806373191 0.175692655823209 no 2791 0.185909895539049 4038 3742339
SGTC_1810 st050138 53 µM -0.89448875955676 0.1753228240015 no 2792 0.185530220612311 3923 3444541
SGTC_190 3970-0790 3.722 µM -0.894567829400927 0.175302229997414 no 2793 0.185509077745179 3871 2832352
SGTC_1524 corynanthine 62.1 µM -0.895684750891752 0.1750114879585 no 2794 0.185210578492374 4101 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist.
SGTC_1272 0839-0021 27 µM -0.897125819120083 0.174636820669759 no 2795 0.184825891431414 3992 5027250
SGTC_3046 9092212 49.47 µM -0.899743906923672 0.173957441046611 no 2796 0.18412827578971 4016 25236637
SGTC_394 menadione 8.33 µM -0.900875675027528 0.173664274301762 no 2797 0.18382721296006 3966 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_2208 7283366 200 µM -0.900994581639126 0.173633491670215 no 2798 0.183795600295343 3933 898663
SGTC_1945 st075991 56.6 µM -0.90148939333351 0.173505431738474 no 2799 0.183664085391858 3998 1084980
SGTC_1209 2323-2347 50.3 µM -0.902040139507378 0.173362966367639 no 2800 0.183517772758606 3962 5412760
SGTC_1499 4480-0877 67.3 µM -0.902330226014761 0.173287957609906 no 2801 0.183440736854986 3893 2861909
SGTC_3130 9127414 49.47 µM -0.902829246711818 0.173158972310627 no 2802 0.183308263179967 3961 1494646
SGTC_2846 9008642 19.48 µM -0.905299354832541 0.172521407284947 no 2803 0.18265340906039 4060 2992898
SGTC_24 0417-1663 219 µM -0.90539925271005 0.172495653960248 no 2804 0.182626955752167 3971 4329390
SGTC_1181 1222-0449 220 µM -0.907098095746599 0.172058073554391 no 2805 0.182177462497655 4022 658318
SGTC_2449 5812982 45.77 µM -0.908514492360836 0.171693786577375 no 2806 0.181803230227379 3943 776185
SGTC_2803 7707263 71.43 µM -0.908958701707965 0.17157964070509 no 2807 0.181685962883591 3956 2199229
SGTC_2833 9001315 45.46 µM -0.909792223343968 0.171365586421225 no 2808 0.181466048290945 3966 2989378
SGTC_504 lovastatin 124 µM -0.912055791607104 0.170785147655086 no 2809 0.180869674353943 4003 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1
SGTC_1492 4158-0558 28.5 µM -0.913473463223658 0.170422260704509 no 2810 0.180496792017328 3974 3967268
SGTC_2629 bisabolol 100 µM -0.913622053473236 0.170384254090214 no 2811 0.180457737082976 4024 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer.
SGTC_1502 4534-4282 27.7 µM -0.914337441765041 0.170201347104704 no 2812 0.180269781169131 3950 3278949
SGTC_325 2810-4341 181 µM -0.919590498707595 0.168862126846612 no 2813 0.178893396847065 3998 774970
SGTC_538 2922-0838 53.3 µM -0.9221823722604 0.168203852851982 no 2814 0.178216728150393 3963 777039
SGTC_593 1203-0218 61.7 µM -0.925546217052339 0.167351981760035 no 2815 0.177340927355186 4044 3666956
SGTC_949 1165-0505 146 µM -0.925674729088389 0.16731949218437 no 2816 0.177307522319472 4032 6244267
SGTC_2791 5663188 71.43 µM -0.926027083641118 0.167230433056049 no 2817 0.177215952710543 4045 54690634
SGTC_2617 dihydrotanshinone i 20.83 µM -0.929397667256219 0.166380048151443 no 2818 0.176341518148241 3998 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12
SGTC_3314 9135860 59.4275 µM -0.929690446149504 0.166306313228897 no 2819 0.176265691250335 4008 25252478
SGTC_3262 9137218 49.47 µM -0.930142354326712 0.166192543810958 no 2820 0.176148691918806 3820 17650664
SGTC_1061 3448-9325 110 µM -0.931145056096921 0.165940289807408 no 2821 0.175889267341502 3900 723482
SGTC_33 0986-0033 35.816 µM -0.932890376772529 0.165501802498214 no 2822 0.175438285748801 3915 2848082
SGTC_1996 st072960 66.8 µM -0.935313181390349 0.164894350375284 no 2823 0.174813462098833 4050 1719405
SGTC_2233 sulbentine 40.3845 µM -0.935367869414649 0.164880655531129 no 2824 0.174799374776483 3995 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58
SGTC_1156 4092-0367 4.88 µM -0.935417607939148 0.164868200768527 no 2825 0.174786563042702 4018 1357585
SGTC_608 k048-0125 159 µM -0.936678229823971 0.164552738502517 no 2826 0.174462048924438 4068 6817652 YLR060W | YFL022C FRS1 | FRS2
SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM -0.93770018870297 0.164297287367778 no 2827 0.174199253417741 4014 364106
SGTC_2125 5246583 200 µM -0.940907567872761 0.163497234500198 no 2828 0.173376114522786 3996 835267
SGTC_3214 9129694 49.47 µM -0.941741179600072 0.163289712244436 no 2829 0.173162583225298 4057 17158655
SGTC_2759 disulfiram 3.38 µM -0.943090681266062 0.162954125449761 no 2830 0.172817260908554 3934 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_812 4251-0442 148 µM -0.943342610734884 0.162891526690347 no 2831 0.172752843635739 4045 5723007
SGTC_1293 1000-1278 195 µM -0.944297262446618 0.162654459296772 no 2832 0.172508882239534 4080 678847
SGTC_2550 chrysin dimethyl ether 71.87 µM -0.945294150807696 0.162407143013245 no 2833 0.172254361891045 3817 88881 An O-methylated flavonoid and antioxidant.
SGTC_2510 benzyl isothiocyanate 8.31 µM -0.948985872045125 0.161493402965835 no 2834 0.171313898807515 4021 2346 DNA damaging agent; causes G2/M arrest.
SGTC_2821 7996764 71.43 µM -0.949595698076302 0.161342787785705 no 2835 0.171158862599512 4072 2987135
SGTC_2883 9059145 45.46 µM -0.950222505502617 0.161188074041 no 2836 0.170999602745086 4005 16476510
SGTC_3318 9139014 38.6185 µM -0.950854806539662 0.161032102417808 no 2837 0.170839043146874 4022 16643984
SGTC_2443 5493264 126.67 µM -0.952082574686374 0.160729526514015 no 2838 0.170527552780397 4066 5340055
SGTC_3043 9092303 49.47 µM -0.952719399119603 0.160572731369524 no 2839 0.170366130845935 4033 25236084
SGTC_771 0250-0039 27.3 µM -0.953064707432455 0.160487753389981 no 2840 0.170278643207169 3985 3005115
SGTC_364 0083-0097 67.7 µM -0.953437630275682 0.160396012671591 no 2841 0.170184191457893 4131 5207356
SGTC_2426 5582046 32.21 µM -0.955108036496727 0.159985505729717 no 2842 0.169761532647777 4051 2251934
SGTC_2467 5474540 200 µM -0.955311601671228 0.15993552603458 no 2843 0.169710071104882 3991 5413519
SGTC_2770 toltrazuril 17.5 µM -0.955347550174201 0.159926700953198 no 2844 0.169700984315805 3937 68591 Kills coccidiodes.
SGTC_2640 pentamidine 10.38 µM -0.957350932460607 0.159435389453813 no 2845 0.16919507790606 4026 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_1239 0337-0584 35.4 µM -0.960084329257183 0.158766644000806 no 2846 0.168506387345464 4124 914301 YML130C ERO1
SGTC_261 5-fluorouridine 15.376 µM -0.961951774954239 0.158310818592074 no 2847 0.168036914506425 4031 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_234 nsc-17383 10.7 µM -0.966312182417109 0.157249831850798 no 2848 0.166943995960954 4056 408974
SGTC_84 0443-0269 128.823 µM -0.967350865326446 0.156997787639702 no 2849 0.166684331925974 3925 6150058
SGTC_484 loperamide 105 µM -0.967759451631974 0.156898713971841 no 2850 0.166582259446887 4024 3955 An opioid-receptor agonist.
SGTC_88 0180-0332 8.668 µM -0.969129496533261 0.156566806900015 no 2851 0.166240291193912 4133 3101745
SGTC_3261 9137475 49.47 µM -0.969488964874534 0.156479798710536 no 2852 0.166150641715305 3976 17027690
SGTC_552 k242-0005 476 µM -0.970573557623622 0.156217469415767 no 2853 0.165880339408076 4139 4088318
SGTC_2361 9034121 116 µM -0.970855477345858 0.156149329262901 no 2854 0.165810125916036 4038 6496917
SGTC_291 SEC14.278 35.5 µM -0.971731550345448 0.155937706938297 no 2855 0.165592058265045 4097 1068044
SGTC_3155 9099265 49.47 µM -0.972163250889587 0.155833495840558 no 2856 0.165484669802136 4085 25236499
SGTC_2944 9067346 25.62 µM -0.972857552177409 0.155665990111458 no 2857 0.165312052119203 4020 6473075
SGTC_2801 7907800 81.82 µM -0.973945378514794 0.15540378218975 no 2858 0.165041830331933 4079 6620925
SGTC_2357 9067248 200 µM -0.974483689589202 0.15527413640384 no 2859 0.164908216861142 4060 9150235
SGTC_2820 7989630 71.43 µM -0.976001169584926 0.154909053851784 no 2860 0.164531942370886 4040 2984098
SGTC_1435 4092-0789 56.7 µM -0.976973163213075 0.154675505126316 no 2861 0.164291219316464 4049 2248285
SGTC_1498 4478-3555 97.6 µM -0.979525839683057 0.154063261469362 no 2862 0.163660113783735 4002 3437919
SGTC_500 h-89 112 µM -0.982712038790828 0.153301323824898 no 2863 0.162874591954448 4106 449241 Protein kinase A inhibitor; also known to inhibit several other kinases.
SGTC_2553 4-methylesculetin 85.09 µM -0.984608057765842 0.152849102706473 no 2864 0.162408315080713 4103 5319502
SGTC_2265 7929201 200 µM -0.985213777298305 0.152704818655128 no 2865 0.162259537302718 4032 1265108
SGTC_2483 5729050 27.16 µM -0.98531058170847 0.152681767955213 no 2866 0.162235768278289 4080 2865180
SGTC_1526 st051518 75 µM -0.985698448168177 0.152589433813029 no 2867 0.162140555610639 4073 673993
SGTC_2210 7115885 190.385 µM -0.98572294019542 0.152583604569898 no 2868 0.162134544579367 4132 2927039
SGTC_1780 st038448 24.544 µM -0.988413841816746 0.151944054359254 no 2869 0.161475005618732 4134 728868 YDL195W SEC31
SGTC_3117 9124945 49.47 µM -0.989119659216248 0.151776597013565 no 2870 0.16130230005756 3979 17592065
SGTC_2027 5150920 200 µM -0.989434305540281 0.151701985742864 no 2871 0.161225348490867 4014 786715
SGTC_123 0083-0120 66.675 µM -0.989527954473404 0.151679783721108 no 2872 0.161202449838731 4037 16001701
SGTC_1743 st037606 46.3785 µM -0.989748163810728 0.151627585629926 no 2873 0.161148613517784 4050 590142 YLR208W | YDL195W SEC13 | SEC31
SGTC_685 1278-0033 54.9 µM -0.992209650800335 0.151044931164462 no 2874 0.160547632843234 4128 3590572
SGTC_2043 5101342 149 µM -0.994364525057083 0.15053607913653 no 2875 0.160022716189087 4094 678451
SGTC_3180 9109287 49.47 µM -0.994606648304645 0.150478975591773 no 2876 0.159963806383246 4118 18891271
SGTC_2621 lithochol-11-enic acid 100 µM -0.999071391982562 0.14942857480553 no 2877 0.158880054213448 4008 6708711
SGTC_2540 epiandrosterone 100 µM -1.00250998983591 0.148622934989169 no 2878 0.158048672085233 4124 441302 A steroid.
SGTC_3021 9087658 49.47 µM -1.00392777109635 0.148291605636188 no 2879 0.15770671479659 4080 25237042
SGTC_2417 cerulenin 830 nM -1.00414855903038 0.148240052950359 no 2880 0.157653506314859 4128 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1
SGTC_1410 3909-8106 77.9 µM -1.00510669782846 0.148016472100971 no 2881 0.157422737644464 4158 1039210
SGTC_193 1273-0060 1.558 µM -1.00513226122838 0.148010509996814 no 2882 0.157416583716813 3895 2847393 YHR072W ERG7
SGTC_1507 4075-3230 155 µM -1.00769077638888 0.147414605327544 no 2883 0.156801467173312 3972 659771
SGTC_890 0929-0006 47.2 µM -1.00915042956975 0.147075358182296 no 2884 0.156451247865793 4065 1378169
SGTC_2294 7971431 200 µM -1.01281407261515 0.14622617537204 no 2885 0.155574488806239 4091 5741572
SGTC_668 1682-0499 62.6 µM -1.01287839890937 0.146211294883689 no 2886 0.155559123667945 4079 682214
SGTC_1956 st077085 54 µM -1.01295861861782 0.146192739224843 no 2887 0.155539963591928 4149 24208685
SGTC_2551 apiole 73.87 µM -1.0144733838501 0.145842655061325 no 2888 0.155178461746103 3974 10659 A possible DNA adduct former.
SGTC_1721 st082152 9.2685 µM -1.01937272933511 0.14471420628317 no 2889 0.15401302387535 4041 5296051
SGTC_155 k072-0202 43.6 µM -1.02056084275941 0.144441440696077 no 2890 0.153731274674309 4036 5857737
SGTC_2779 methotrexate 400 µM -1.02112638763594 0.144311725397021 no 2891 0.153597281310665 4124 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2
SGTC_1080 nisoldipine 24.4 µM -1.02114417260128 0.144307647450628 no 2892 0.153593068810675 4105 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class.
SGTC_1231 0242-0792 125 µM -1.02160939531523 0.144201003294925 no 2893 0.153482904559407 4105 3707635
SGTC_2052 5265182 7.135 µM -1.02358876383063 0.143747861784978 no 2894 0.153014777301909 4125 1239884
SGTC_2586 curcumin 80 µM -1.02390729554069 0.143675029418106 no 2895 0.152939531998875 4061 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40
SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM -1.02392999806685 0.143669839429853 no 2896 0.152934170020685 4070 6708514
SGTC_2927 9011802 47.9 µM -1.02439905368616 0.14356263768463 no 2897 0.152823414380821 4133 43912568
SGTC_2401 5128683 200 µM -1.02503508576559 0.143417360060385 no 2898 0.152673316453099 4108 708373
SGTC_1597 7-benzyloxygramine 47.5 µM -1.02524469234914 0.143369505067297 no 2899 0.152623872590709 4052 260807
SGTC_2687 chenodiol 100 µM -1.02938829614746 0.142425697773017 no 2900 0.151648623332676 4214 5702181 A cholesterol synthesis inhibitor.
SGTC_2381 9035592 200 µM -1.03000100050083 0.142286496835205 no 2901 0.15150476795715 4115 4749657
SGTC_1618 st003135 44.5 µM -1.03270032084364 0.141674331788617 no 2902 0.150872081678517 4065 1270615
SGTC_539 4859-0462 2.54 µM -1.03293790364716 0.141620537152721 no 2903 0.150816479631536 4166 46499474 YNL221C | YBR257W POP1 | POP4
SGTC_772 k072-0172 35.3 µM -1.03427912822428 0.141317110241516 no 2904 0.150502845685485 4165 5861980
SGTC_496 calpeptin 138 µM -1.03658091708489 0.140797401414921 no 2905 0.149965605277255 4142 73364 A calpain inhibitor.
SGTC_703 3875-0075 71.8 µM -1.03929724408545 0.140185766305219 no 2906 0.149333258082341 4173 2850814
SGTC_985 1493-0307 8.71 µM -1.03957711343282 0.140122850863566 no 2907 0.14926820721616 4148 3278274
SGTC_2207 7258803 200 µM -1.04042033222452 0.139933408809337 no 2908 0.149072329755857 4103 3666799
SGTC_2750 bromebric acid 70.15 µM -1.04188129830018 0.139605592549366 no 2909 0.148733357875295 4178 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2
SGTC_2095 5432005 200 µM -1.04469622876333 0.138975442874007 no 2910 0.148081694187909 4145 783734
SGTC_3302 9125395 16.351 µM -1.04638796300746 0.138597664662605 no 2911 0.147690973948959 4083 17599668
SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM -1.04859094011696 0.138106771312365 no 2912 0.14718321370928 4136 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding.
SGTC_2608 thymoquinone 42.66 µM -1.04957609531239 0.13788763152618 no 2913 0.146956526180303 4133 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC).
SGTC_366 0181-0206 4.31 µM -1.05168742284298 0.137418783142981 no 2914 0.146471491628353 4174 274874
SGTC_1784 st039334 36.3 µM -1.05193086664678 0.137364793279074 no 2915 0.146415634544239 4209 3496984
SGTC_2021 4019055 173 µM -1.0521311504457 0.137320386107323 no 2916 0.146369691052503 4011 44827708 YER133W GLC7
SGTC_2050 5263056 171 µM -1.05575250375949 0.136519146210296 no 2917 0.145540651455791 4146 763468 YGL055W OLE1
SGTC_3263 9137018 49.47 µM -1.05640027350189 0.13637616219858 no 2918 0.145392690548803 4127 43844957
SGTC_2515 chrysin 20.77 µM -1.0568226517953 0.13628298466609 no 2919 0.145296267148053 4172 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor.
SGTC_1666 st014829 29 µM -1.05893670830593 0.135817274093454 no 2920 0.144814302542962 4133 3858230
SGTC_3100 9120536 49.47 µM -1.06059032912473 0.135453754500818 no 2921 0.144438059727301 3985 16421196
SGTC_1719 st032227 49.2 µM -1.06097812856211 0.135368600190338 no 2922 0.144349920457971 4158 3125804
SGTC_2157 5649910 96.377 µM -1.06347678662286 0.134820816279317 no 2923 0.143782893410485 4151 2858091
SGTC_1514 1189-1591 158 µM -1.06724555837356 0.133997464096957 no 2924 0.14293048244487 4184 767698 YMR146C TIF34
SGTC_1569 carminic acid 40.6 µM -1.06769910620076 0.133898612288756 no 2925 0.142828130879702 4255 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_249 wiskostatin 11.211 µM -1.07113608223624 0.133151144297491 no 2926 0.142054123160705 4119 2775510 A n-wasp and actin depolymerizer.
SGTC_2286 7945697 125 µM -1.07315672778514 0.13271304045637 no 2927 0.141600401080099 4200 1245733
SGTC_1087 pterostilbene 9.05 µM -1.07456896339978 0.132407438347523 no 2928 0.141283876771207 4209 5281727 Similar to reservatol, lowers cholesterol.
SGTC_2932 9016711 44.54 µM -1.07477686682101 0.132362489868629 no 2929 0.141237319919614 4182 7117328
SGTC_3188 9110789 49.47 µM -1.07543258230503 0.132220793834452 no 2930 0.141090550414074 4162 849217
SGTC_648 0375-0473 33.3 µM -1.07618466608285 0.132058402007009 no 2931 0.140922338076245 4149 1713139
SGTC_1248 0469-0687 58.6 µM -1.07796168803565 0.131675249516557 no 2932 0.140525426964623 4144 4017482
SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM -1.07881517953075 0.13149149696753 no 2933 0.140335063304749 4195 551469
SGTC_3101 9120531 49.47 µM -1.0838731398136 0.130406176072261 no 2934 0.139210525234277 4208 24824904
SGTC_2670 beta-carotene 100 µM -1.08419698268054 0.13033689858718 no 2935 0.139138734610451 4115 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.)
SGTC_83 0170-0301 39.027 µM -1.08553144195523 0.1300516954902 no 2936 0.13884317286974 4188 3089716
SGTC_1421 4029-0249 71.4 µM -1.08607771631539 0.129935069421088 no 2937 0.138722305114301 4254 2894095
SGTC_2734 clemastine 41.6 µM -1.08611862874181 0.12992633779592 no 2938 0.138713255784608 4227 26987 Clemastine is a selective histamine H1 antagonist.
SGTC_274 sirtinol 40.1 µM -1.08635300586189 0.129876324315243 no 2939 0.138661422174421 4239 6836442 NAD-dependent acetyltransferase inhibitor.
SGTC_984 1492-0255 2.91 µM -1.0868272307239 0.129775170756928 no 2940 0.1385565854612 4149 1585198
SGTC_1675 st018485 24.5 µM -1.09312185406793 0.128437675899831 no 2941 0.1371701509424 4221 3323024
SGTC_185 k048-0037 25.491 µM -1.09353962841667 0.128349246184167 no 2942 0.137078469786162 4236 6827589
SGTC_2616 abietic acid 100 µM -1.09445771672598 0.128155064249607 no 2943 0.136877141163945 4230 6708678 Abietic acid is an inhibitor of 5α-reductase.
SGTC_3258 9138477 49.47 µM -1.09698318858962 0.127621962690794 no 2944 0.136324370575766 4202 4970355
SGTC_322 k048-0136 19.3 µM -1.09731477443895 0.127552082938197 no 2945 0.136251907272466 4254 6823282
SGTC_2650 prasterone 100 µM -1.09944412802821 0.127103968271526 no 2946 0.135787195890112 4175 16759247 A steroid and weak partial agonist of the androgen receptor.
SGTC_1824 st053723 68.6 µM -1.10044738327443 0.126893216992183 no 2947 0.135568621507324 4230 675225
SGTC_2006 4011487 200 µM -1.10179689896931 0.126610111527918 no 2948 0.135274989425696 4213 45595294
SGTC_2023 5144124 124 µM -1.10283007620516 0.126393666030498 no 2949 0.135050482177589 4179 2830192
SGTC_2858 9025781 8.96 µM -1.1063408459463 0.125660104275678 no 2950 0.134289509349788 4095 4894980 YPL153C RAD53
SGTC_2320 7373003 200 µM -1.10683439980346 0.125557216735914 no 2951 0.134182766211524 4252 5415828
SGTC_1491 4138-0063 26.5 µM -1.10729201313247 0.125461873987024 no 2952 0.134083848177808 4171 23883227
SGTC_165 k038-0023 64.381 µM -1.11135727533961 0.12461710348023 no 2953 0.133207297460672 4203 46368543
SGTC_2408 sulbentine 18.36 µM -1.11375763732231 0.124120173958292 no 2954 0.13269158760705 4126 67686 An antifungal agent of unknown mechanism. YDL205C HEM3
SGTC_965 1291-5240 308 µM -1.11516805726826 0.123828832432369 no 2955 0.132389205781777 4230 2834598
SGTC_669 0108-0021 26.2 µM -1.11649456952224 0.123555260329077 no 2956 0.132105246703799 4135 17201
SGTC_676 falcarinol 140 µM -1.11865485793905 0.123110641640229 no 2957 0.131643705232032 4250 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer.
SGTC_189 3970-0742 2.116 µM -1.11976198210283 0.122883214580278 no 2958 0.131407602072826 4149 2891807
SGTC_832 4083-0019 164 µM -1.12039650055808 0.122753003758139 no 2959 0.131272417764979 4288 1990758
SGTC_186 3455-3465 67.277 µM -1.12181750726657 0.122461747198219 no 2960 0.130970020415187 4202 755278
SGTC_187 1488-2104 32.728 µM -1.12325467328034 0.122167672144207 no 2961 0.130664674201518 4232 2852859
SGTC_1387 3342-1166 1.8 µM -1.12573410146816 0.121661494120876 no 2962 0.130139042403385 4195 3418228
SGTC_1916 st067606 49.2 µM -1.12623544762356 0.121559323139563 no 2963 0.130032936529613 4141 19590279
SGTC_1974 st069448 26.9 µM -1.12661673838596 0.121481659027239 no 2964 0.129952279510152 4208 6323587 YNR016C ACC1
SGTC_1333 1482-0047 286 µM -1.12866132793009 0.121065796982196 no 2965 0.129520364446946 4230 3811116
SGTC_1206 3978-0017 132 µM -1.12896961091584 0.121003180340962 no 2966 0.129455326725473 4305 3873677
SGTC_577 r071-0003 38.6 µM -1.12996144101217 0.120801880194355 no 2967 0.129246236238627 4215 4568517 YMR134W ERG29
SGTC_545 4218-0007 221 µM -1.13583286558818 0.119615053312667 no 2968 0.128013259712565 4207 2840508
SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM -1.13638339620444 0.119504194397783 no 2969 0.127898070834628 4262 6728940
SGTC_885 0865-0106 16.8 µM -1.13715167466473 0.119349609353634 no 2970 0.127737442453524 4164 2793380
SGTC_2248 tofa 1.1 µM -1.13887467592847 0.119003438096781 no 2971 0.127377714709152 4206 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_1454 4239-0054 42.6 µM -1.14025765663326 0.118726094351487 no 2972 0.127089486561238 4336 1340767
SGTC_882 0843-0131 351 µM -1.14046872967783 0.118683805838834 no 2973 0.127045536605476 4232 5425421
SGTC_373 0844-0104 25.9 µM -1.1415972877297 0.118457879647611 no 2974 0.126810725976322 4252 5375804
SGTC_326 k292-0812 17.5 µM -1.14342510925635 0.118092612958475 no 2975 0.126431066132468 4224 3579357
SGTC_1645 Cervolide 78 µM -1.1445708229767 0.117864063316845 no 2976 0.126193492200203 4237 23173 A fragrance.
SGTC_1638 st008370 60.6 µM -1.14534111863936 0.117710578993115 no 2977 0.12603393957513 4191 24207134
SGTC_2321 7390090 138.78 µM -1.14751281258093 0.117278622515202 no 2978 0.125584870420516 4261 649046
SGTC_1464 k208-0027 110 µM -1.14832762295161 0.117116844277906 no 2979 0.12541666996183 4250 X1464
SGTC_1652 st011932 78 µM -1.14858400961703 0.117065972166487 no 2980 0.125363776866703 4182 1551076
SGTC_1423 4048-0112 5.59 µM -1.14896894799864 0.116989622293674 no 2981 0.125284392532755 4283 X1423
SGTC_998 3996-0085 177 µM -1.1505293196898 0.116680494783018 no 2982 0.124962962690604 4277 715391
SGTC_1509 1326-1131 80 µM -1.15059541724987 0.116667412897585 no 2983 0.124949359608146 4201 768313
SGTC_400 oxethazaine 37.5 µM -1.15133398821793 0.116521307269004 no 2984 0.124797429774178 4240 4621 A local anesthetic.
SGTC_2746 daunorubicin 9.88 µM -1.15445638448258 0.115905062545719 no 2985 0.124156555072433 4201 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_2946 9065502 71.43 µM -1.15685128671493 0.115433968743498 no 2986 0.123666561957152 4072 16489101
SGTC_133 0724-0033 378.92 µM -1.15762414420501 0.115282233142375 no 2987 0.123508725947211 4069 280309
SGTC_2230 bromochlorosalicylanilide 954.5 nM -1.15811651587301 0.115185639463568 no 2988 0.123408245467821 4266 77254
SGTC_2563 tomatine 8.54 µM -1.15867873679855 0.115075413107892 no 2989 0.123293580584113 4230 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties.
SGTC_369 0957-0393 4.5 µM -1.16096519923646 0.114627913007269 no 2990 0.122828026088692 4273 6997992
SGTC_2863 9028737 58.44 µM -1.16632737588648 0.113583303977989 no 2991 0.12174105443115 4235 6460917
SGTC_308 4092-1169 104 µM -1.16646203001806 0.113557159568461 no 2992 0.121713845842896 4190 2268590 YDL196W YDL196W
SGTC_1025 k007-0731 70 µM -1.16742651139453 0.1133700215548 no 2993 0.121519084965073 4222 6256118
SGTC_2212 7123476 200 µM -1.16843172731129 0.113175214033238 no 2994 0.121316331677418 4252 1085715
SGTC_41 0478-0632 82.643 µM -1.17166098664616 0.112551010627973 no 2995 0.120666596103852 4229 3750424
SGTC_2488 5268135 45.7 µM -1.17205032975825 0.11247591854066 no 2996 0.120588425034778 4319 1270356 YLR208W SEC13
SGTC_2852 9023854 51.95 µM -1.1755209924698 0.111808117612515 no 2997 0.119893171828258 4299 19798528
SGTC_39 0986-0283 58.349 µM -1.17755942627153 0.111417220658778 no 2998 0.119486146608347 4344 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2
SGTC_2581 avocatin a 64 µM -1.17964460306101 0.111018373133755 no 2999 0.119070797619195 4226 6710728 A skin care supplement.
SGTC_2954 9074818 52.69 µM -1.18128829743099 0.110704692826459 no 3000 0.118744107314068 4288 16648742
SGTC_2848 9016370 25.97 µM -1.18283168587431 0.110410733414191 no 3001 0.118437930070846 4271 7894410
SGTC_2253 7938677 135.83 µM -1.18317678889434 0.110345080460835 no 3002 0.118369544972724 4331 2301972
SGTC_2092 5303694 80.6725 µM -1.18790668549339 0.109448077222512 no 3003 0.117435087740853 4264 1963699
SGTC_906 1165-0455 526 µM -1.18994596050667 0.109062958097844 no 3004 0.117033816232764 4256 3252859
SGTC_142 0335-0849 62.6745 µM -1.19064574334943 0.108931028120631 no 3005 0.116896342972137 4267 3889043 YPR107C YTH1
SGTC_156 3474-0145 5.642 µM -1.19308945219754 0.108471215901733 no 3006 0.116417170993367 4153 2265471
SGTC_1982 st072467 71.9 µM -1.19389596601835 0.108319767873254 no 3007 0.116259332851538 4254 3163533
SGTC_1934 st074720 32.6 µM -1.19788701013712 0.107572564861234 no 3008 0.115480503713975 4229 17250992
SGTC_1616 st002734 56.1 µM -1.19978352608031 0.107218804002895 no 3009 0.115111711898171 4218 4026101
SGTC_2154 5570129 200 µM -1.20366126067787 0.106498095180621 no 3010 0.1143602655714 4335 673366
SGTC_2838 9002687 71.43 µM -1.20530137850618 0.106194320632228 no 3011 0.114043488824451 4279 6457060
SGTC_1668 st014914 51.6 µM -1.20581708369332 0.106098933723378 no 3012 0.113944013441958 4296 2839556
SGTC_2055 5235184 200 µM -1.20696632697269 0.105886587767524 no 3013 0.113722556095239 4333 2836034
SGTC_570 0987-0065 62.6 µM -1.20841070744346 0.105620145068619 no 3014 0.113444661608369 4111 3104428
SGTC_2231 micatex 6.853 µM -1.20980691961258 0.105363049034251 no 3015 0.113176495204381 4304 20737 An antifungal of unknown mechanism.
SGTC_1643 st009866 20.2 µM -1.21279275017362 0.104814763404374 no 3016 0.112604533964073 4249 3156273 YOR207C RET1
SGTC_851 0394-0702 453 µM -1.2174785951344 0.103958475669755 no 3017 0.111711087796178 4303 762646
SGTC_1500 4488-1866 171 µM -1.21888820751782 0.103701879510969 no 3018 0.111443313044731 4366 2900003
SGTC_1200 1643-0193 18.4 µM -1.21889808032988 0.103700083953941 no 3019 0.111441439193226 4323 5403974
SGTC_2976 9009005 19.48 µM -1.21895591852407 0.103689565440894 no 3020 0.111430462005147 4321 2993148
SGTC_401 neomycin 50 µM -1.22049761991196 0.103409475306904 no 3021 0.111138145627087 4278 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis.
SGTC_1547 harmine 94.2 µM -1.22063833004261 0.103383939030231 no 3022 0.11111149346331 4246 5280953 A monoamine oxidase inhibitor YHR072W ERG7
SGTC_1490 4089-0339 670 nM -1.22176313142172 0.103179972998227 no 3023 0.110898607289529 4275 742542
SGTC_2094 5332512 191.667 µM -1.22179480619063 0.103174233482476 no 3024 0.110892616579307 4327 755774
SGTC_1990 st072050 59.8 µM -1.22455360143044 0.102675224760561 no 3025 0.110371729430246 4298 17233948
SGTC_2384 9036245 200 µM -1.22704913108043 0.102225348447227 no 3026 0.10990206269339 4229 6462766
SGTC_1318 1280-3875 124 µM -1.22791705232666 0.102069222325116 no 3027 0.109739053745736 4306 373245
SGTC_1371 2421-0008 32.7 µM -1.22792741117345 0.102067359970945 no 3028 0.109737109243781 4291 2827552
SGTC_2114 5491910 81.25 µM -1.23038810463575 0.101625667057626 no 3029 0.109275902835448 4351 2849228
SGTC_1254 0550-0035 264 µM -1.23308088590938 0.101143911264245 no 3030 0.108772793980154 4320 15121435
SGTC_2690 usnic acid 100 µM -1.23350519655473 0.101068151419207 no 3031 0.108693669568164 4340 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_1348 1493-0373 93.8 µM -1.23518259800318 0.100769059584103 no 3032 0.108381277128184 4336 3010129
SGTC_282 k297-0036 65.7 µM -1.23679985055615 0.100481304356818 no 3033 0.108080698792473 4321 5061378
SGTC_2370 9071495 200 µM -1.23839783768195 0.100197566321664 no 3034 0.107784291011781 4311 21791103
SGTC_1714 st033236 13.627 µM -1.24209325341153 0.0995436507037038 no 3035 0.107101078739773 4354 2916566
SGTC_3249 9135183 49.47 µM -1.24390991213474 0.0992233329971041 no 3036 0.106766360433668 4302 4902779
SGTC_3091 9116372 49.47 µM -1.2439325746224 0.0992193418572758 no 3037 0.10676218965617 4375 17169793
SGTC_1997 st073024 93.8 µM -1.24610081252588 0.0988380314868298 no 3038 0.106363693289161 4338 686268
SGTC_3315 9136395 68.55 µM -1.24779340258829 0.0985411155022501 no 3039 0.106053362681809 4311 16876844
SGTC_708 3448-5400 146 µM -1.24829055539455 0.0984540286122823 no 3040 0.105962335831806 4284 3462195
SGTC_862 0452-0056 10.2 µM -1.24856900128546 0.0984052775181151 no 3041 0.105911378086505 4284 1575396 YLR359W | YHR072W ADE13 | ERG7
SGTC_2239 6685329 187.64 µM -1.2512039230182 0.0979448228302629 no 3042 0.10543004365953 4356 805680
SGTC_1486 3970-0793 4.53 µM -1.25330132374994 0.0975794305616078 no 3043 0.105048033438518 4363 2844330
SGTC_1883 5-benzylidenerhodanine 20 µM -1.25547627477367 0.0972015848908727 no 3044 0.104652957745112 4312 1273210
SGTC_1151 3909-8316 15.3 µM -1.25829523163864 0.0967134576462895 no 3045 0.104142502507716 4363 800431
SGTC_521 r062-0005 13.8 µM -1.25919260112364 0.0965584486091325 no 3046 0.103980386682203 4257 2832033
SGTC_111 0083-0039 52.457 µM -1.25989503569878 0.0964372394795447 no 3047 0.10385361490639 4271 759313
SGTC_1023 4482-3888 16 µM -1.2633777676413 0.0958379250959083 no 3048 0.103226725044348 4362 3303168
SGTC_654 1124-0271 80.9 µM -1.26594099534281 0.0953985938385697 no 3049 0.102767103914436 4320 5403748
SGTC_950 1165-0508 94.1 µM -1.26644846215881 0.0953117912952819 no 3050 0.102676284938552 4333 6148369
SGTC_1455 4262-0120 131 µM -1.26777853851045 0.0950845567933465 no 3051 0.102438524209732 4400 1529587
SGTC_20 0481-0013 4.944 µM -1.26886227217627 0.094899703470901 no 3052 0.102245095188982 4386 182045
SGTC_69 0096-0274 206.684 µM -1.27010746577015 0.0946876368382463 no 3053 0.102023176314697 4454 6741392
SGTC_1191 1487-1166 10.6 µM -1.2752949438047 0.0938079249281844 no 3054 0.101102433350788 4379 3955771
SGTC_479 n-linoleoylglycine 10 µM -1.27660341983151 0.0935869845106455 no 3055 0.100871146954125 4385 6433346 An anti-infammatory.
SGTC_531 3788-1495 174 µM -1.27920813058935 0.0931483149109586 no 3056 0.100411886735211 4332 2896655
SGTC_411 enrofloxacin 100 µM -1.28131992663841 0.092793775904595 no 3057 0.100040658275836 4405 71188 A bacterial gyrase inhibitor.
SGTC_2655 perillic acid 100 µM -1.28311724658664 0.0924928196039713 no 3058 0.099725501184158 4382 5702197 An apoptosis inducer.
SGTC_788 1182-0090 188 µM -1.28650032772495 0.0919282919796649 no 3059 0.0991342522601364 4358 5715185
SGTC_2080 5212524 12.4 µM -1.28891734741695 0.0915265345488465 no 3060 0.098713411243449 4309 260183
SGTC_2516 gossypol 71.55 µM -1.2988335115299 0.0898918836667079 no 3061 0.0970005356709197 4378 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_1178 0988-0033 191 µM -1.29911251404269 0.0898462068042412 no 3062 0.0969526595522706 4405 5392207
SGTC_2996 9066192 71.4286 µM -1.30467449348195 0.0889392245402773 no 3063 0.0960018551618196 4377 6472854
SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM -1.30481920803475 0.0889157175055126 no 3064 0.0959772084746686 4351 2724278 An inhibitor of dopamine biosynthesis.
SGTC_968 1309-0633 340 µM -1.30593893743781 0.0887339880684117 no 3065 0.0957866619149849 4406 3761976
SGTC_1679 SEC14.276 6.7 µM -1.30826589457938 0.0883572133574011 no 3066 0.0953915693777606 4352 1005053 YMR079W SEC14
SGTC_2839 9003951 25.97 µM -1.3084167813541 0.0883328233939899 no 3067 0.0953659918880007 4420 2990634
SGTC_530 4358-1714 28 µM -1.30985195401061 0.0881010869102379 no 3068 0.0951229617231515 4373 1564641
SGTC_557 1315-0110 16.2 µM -1.31212997589584 0.0877341871926784 no 3069 0.0947381417132314 4361 6833801
SGTC_1136 pergolide 1.05886 µM -1.31369324296246 0.0874830666634543 no 3070 0.0944747278875605 4314 47811 A dopamine receptor agonist.
SGTC_1981 st071826 47 µM -1.31568841517403 0.0871633453686499 no 3071 0.0941393220524251 4414 11838600
SGTC_1125 tnp00248 1.32998 µM -1.31571478116593 0.087159126134555 no 3072 0.0941348955882382 4412 24207736
SGTC_2884 9058502 51.95 µM -1.31709730573826 0.0869381003984538 no 3073 0.0939030050142338 4393 6471554
SGTC_2172 5754775 163.918 µM -1.31714593155686 0.0869303341643401 no 3074 0.0938948566970574 4359 2263357
SGTC_1672 st016598 6.51 µM -1.31816109593318 0.0867683163234689 no 3075 0.0937248629026771 4348 4665860 YNL267W PIK1
SGTC_3250 9135583 49.47 µM -1.31895947523181 0.0866410554624584 no 3076 0.0935913304326897 4402 7699353
SGTC_1358 1509-0022 2.48 µM -1.31908681605387 0.086620770369597 no 3077 0.0935700451140758 4401 3258434
SGTC_1197 1601-0112 267 µM -1.31917977117403 0.0866059650795955 no 3078 0.093554509703965 4350 7350313
SGTC_2939 9044578 71.43 µM -1.32319204960121 0.0859687167546933 no 3079 0.0928857596310498 4311 2653634
SGTC_1129 3453-1384 223 µM -1.33041537111073 0.084830330583548 no 3080 0.0916907264315491 4411 1084452
SGTC_793 0488-0545 106 µM -1.33063063689678 0.084796579247811 no 3081 0.0916552882712172 4415 292548
SGTC_1172 0370-0043 85 µM -1.33131438691527 0.0846894414597605 no 3082 0.0915427931392977 4414 376585
SGTC_2119 5528445 120.635 µM -1.3319726387847 0.0845863949550315 no 3083 0.0914345898358958 4419 791935
SGTC_3342 9147791 14.508 µM -1.33398596100112 0.0842718017483002 no 3084 0.0911042287778544 4352 1838168
SGTC_2731 amoxapine 43.43 µM -1.33412085135707 0.0842507557815699 no 3085 0.0910821266366164 4547 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine.
SGTC_2897 9048598 12.99 µM -1.34011930711527 0.0833188433536065 no 3086 0.0901032800399767 4370 6467404
SGTC_2267 7931562 200 µM -1.34041981346575 0.0832723617181702 no 3087 0.090054448856744 4346 934880
SGTC_3241 9133421 49.47 µM -1.34094743016072 0.0831907983409885 no 3088 0.0899687606459275 4476 17018221
SGTC_3018 9082602 49.47 µM -1.34122295639995 0.0831482290855397 no 3089 0.0899240375709229 4316 17332089
SGTC_1071 trifluoperazine 6.31 µM -1.34136851021246 0.0831257473962807 no 3090 0.0899004181283893 4444 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels.
SGTC_864 0469-0573 172 µM -1.34267697434604 0.0829238522014641 no 3091 0.0896882968211889 4375 689425
SGTC_1066 ketoconazole 628 nM -1.34524752134303 0.0825282929407714 no 3092 0.0892726572698688 4455 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W
SGTC_548 1436-0017 110 µM -1.35191946496497 0.0815082347365199 no 3093 0.0882005399666269 4438 9677137
SGTC_2701 st077767 14.721 µM -1.35509221921576 0.0810265081635476 no 3094 0.0876940886904707 4382 5721188
SGTC_834 0312-0008 75.7 µM -1.35625687836817 0.0808502154914305 no 3095 0.0875087252347618 4426 6385573 YIL048W NEO1
SGTC_933 2914-0560 114 µM -1.35723028703042 0.0807030944008072 no 3096 0.0873540250546703 4407 463887
SGTC_886 0866-0150 153 µM -1.35748539517263 0.0806645707838429 no 3097 0.0873135154597742 4450 271463
SGTC_2893 9048488 25.97 µM -1.35827679088498 0.080545151302249 no 3098 0.0871879359541991 4437 6467338
SGTC_1594 piperine 70.1 µM -1.36021910319046 0.0802526277511506 no 3099 0.086880299555595 4402 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_637 1181-0519 7.26 µM -1.3605380878121 0.0802046636641294 no 3100 0.0868298542645965 4415 6252091 YGR060W ERG25
SGTC_3292 9120825 59.784 µM -1.3665680801951 0.0793020358093498 no 3101 0.085880363988888 4393 24824900
SGTC_1298 1079-1278 263 µM -1.37172328678797 0.0785364698294119 no 3102 0.0850747981340278 4400 2840950
SGTC_1369 1866-0067 208 µM -1.37337828944847 0.0782918879507361 no 3103 0.0848173877516178 4440 3531355
SGTC_451 chloral hydrate 100 µM -1.37824930114551 0.0775753851835067 no 3104 0.0840631652005724 4420 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1
SGTC_1630 st005209 31.3 µM -1.37853797218871 0.0775330798312066 no 3105 0.0840186262214059 4414 3367314
SGTC_1549 4'-methoxyflavonol 74.6 µM -1.37856306677091 0.0775294029949047 no 3106 0.084014755222172 4361 97141
SGTC_928 2764-0428 58.7 µM -1.37863821732732 0.0775183927928797 no 3107 0.0840031635708877 4452 662578
SGTC_2918 7977171 22.06 µM -1.38256077132462 0.0769453518506652 no 3108 0.0833997922379648 4408 2236483
SGTC_1686 st019653 115.5 µM -1.39228245929141 0.0755390072282786 no 3109 0.0819184405074623 4430 97252
SGTC_3073 9114972 49.47 µM -1.3952368276948 0.0751155307241905 no 3110 0.0814722174274426 4439 41905075
SGTC_2241 6772625 37.8075 µM -1.40042846423371 0.0743757553752752 no 3111 0.0806925256091025 4230 2285411
SGTC_2671 danthron 100 µM -1.40302385133422 0.0740080209989627 no 3112 0.0803048633156051 4427 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin.
SGTC_2337 9009472 200 µM -1.40382257126789 0.0738951322103855 no 3113 0.0801858454633491 4412 5742383
SGTC_1292 0kpi-0043 232 µM -1.40442925171411 0.073809473703056 no 3114 0.0800955326905669 4459 3333905
SGTC_1098 clofazimine 15.1 µM -1.40582674770045 0.0736124470304477 no 3115 0.0798877886949617 4491 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2
SGTC_450 aminopyrene 156 nM -1.40688807288631 0.0734630844104137 no 3116 0.0797302904190552 4387 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1
SGTC_2878 9043973 25.97 µM -1.40732804993736 0.0734012334742157 no 3117 0.0796650677237873 4449 6465167
SGTC_819 1013-0258 27.7 µM -1.40833236019005 0.0732601991337209 no 3118 0.0795163388760753 4438 5753198
SGTC_956 1185-0240 191 µM -1.41329803475157 0.072565918951409 no 3119 0.0787840558006755 4418 1416193
SGTC_2875 9039966 71.43 µM -1.41369068824617 0.07251123549752 no 3120 0.078726370300333 4432 6463691
SGTC_1922 5578187 25 µM -1.41854439799712 0.0718378808458078 no 3121 0.0780159430185375 4450 1350412
SGTC_877 0771-0151 33.1 µM -1.42244313684915 0.0713004906778602 no 3122 0.077448823967461 4461 6166523
SGTC_2732 terfenadine 20 µM -1.42385679285542 0.071106400843328 no 3123 0.0772439657370841 4514 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.
SGTC_1899 st063254 59.6 µM -1.42394189865907 0.0710947290861937 no 3124 0.0772316458840995 4413 3093813
SGTC_51 1013-0126 23.419 µM -1.42731037959974 0.0706339423964375 no 3125 0.0767452250451889 4450 1627850
SGTC_1667 st014849 34.6 µM -1.42980388355513 0.0702943279250155 no 3126 0.0763866570855895 4537 5348460
SGTC_2368 9071271 200 µM -1.43019483647562 0.0702411943221948 no 3127 0.0763305535107338 4424 27209959
SGTC_1877 wortmannin 25 µM -1.43056188671115 0.070191337401667 no 3128 0.0762779086267151 4481 312145 A covalent inhibitor of PI 3-kinase.
SGTC_472 calcifediol 10 µM -1.43158941155374 0.0700519120865648 no 3129 0.0761306808513383 4487 5283731 A vitamin D metabolite.
SGTC_1414 3917-0015 5.4 µM -1.43929077669947 0.0690136842845741 no 3130 0.0750340774776897 4461 6618702
SGTC_2440 5628896 157.78 µM -1.44014970591582 0.0688986302682745 no 3131 0.0749125244232709 4427 5522048
SGTC_1273 0849-0096 14.1 µM -1.44102525045188 0.0687815028592076 no 3132 0.0747887746734609 4486 5286025
SGTC_2120 5538279 151.968 µM -1.44647860980833 0.0680554239091551 no 3133 0.0740215036562043 4438 2058197
SGTC_1236 0330-0013 258 µM -1.44802468413504 0.0678506546613399 no 3134 0.0738050736461999 4486 4617066
SGTC_2697 mebhydrolin 72.4 µM -1.449250674068 0.0676886173990398 no 3135 0.0736337953189412 4493 22530 H1 Histamine receptor antagonist. YIL048W NEO1
SGTC_130 0136-0219 337.655 µM -1.45302836479002 0.0671912050885183 no 3136 0.0731079393490537 4333 234244
SGTC_1230 0170-0365 3.77 µM -1.45960346806387 0.0663322010798229 no 3137 0.0721995427870294 4501 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1
SGTC_1600 coumarin 106 71.1 µM -1.46147801478252 0.0660888654654221 no 3138 0.0719421523446309 4534 100336 A hepatotoxic, DNA x-linker.
SGTC_3027 9089541 49.47 µM -1.46385665086784 0.0657810900033169 no 3139 0.0716165599092005 4462 9943819
SGTC_2991 9074669 71.4286 µM -1.46944251779426 0.0650626944032898 no 3140 0.0708564010891662 4429 17333109
SGTC_2089 5281248 129.67 µM -1.47068577311751 0.0649036314562525 no 3141 0.0706880577254944 4461 2737878
SGTC_2263 7948595 193.29 µM -1.47187974802753 0.064751157816954 no 3142 0.0705266766760169 4497 2971371
SGTC_884 0851-0618 334 µM -1.47769924092924 0.0640119723065866 no 3143 0.0697441488321712 4503 9642473
SGTC_251 melphalan 456.522 µM -1.47932286408245 0.0638069165674525 no 3144 0.0695270224530769 4521 460612 A DNA alkylator.
SGTC_665 3914-0008 307 µM -1.48033688053825 0.0636791106277675 no 3145 0.0693916827813989 4451 1069549
SGTC_951 1171-0579 82.7 µM -1.48298879676474 0.0633458064378059 no 3146 0.069038693675372 4429 1616050 YPR165W | YDR526C RHO1 | YDR526C
SGTC_1737 st035557 69.7 µM -1.48591078281045 0.0629801329963264 no 3147 0.0686513605458798 4326 5716916
SGTC_1305 1181-0477 144 µM -1.48745696671981 0.0627873014044079 no 3148 0.0684470804040914 4537 6252086
SGTC_2259 7964009 200 µM -1.48747738226676 0.0627847583700762 no 3149 0.0684443862645202 4501 313134
SGTC_2026 5148700 152 µM -1.49349524353342 0.062038644341231 no 3150 0.0676537991997644 4475 79838
SGTC_2865 9030313 51.95 µM -1.49398624216452 0.061978075300712 no 3151 0.067589607615521 4482 42562754
SGTC_3047 9092122 49.47 µM -1.49510252925969 0.0618405430973073 no 3152 0.0674438429510539 4482 17173831
SGTC_1676 st018489 23.4 µM -1.49602082779471 0.0617275827676745 no 3153 0.0673241138520572 4471 3696235
SGTC_897 1000-0139 31.4 µM -1.49742115250877 0.061555638370854 no 3154 0.0671418538711572 4454 6151020
SGTC_2495 cafestol 54.53 µM -1.50524823446211 0.0606014383399866 no 3155 0.066130134225778 4491 16667697 An anti-infammatory.
SGTC_3204 9114183 49.47 µM -1.51532337772117 0.0593902562973071 no 3156 0.0648452654365737 4456 17027248
SGTC_2454 5-benzylidenerhodanine 10.36 µM -1.52102181785112 0.0587136690447727 no 3157 0.0641271811385422 4551 1273210
SGTC_2997 9067075 71.4286 µM -1.52147074813508 0.0586606247907766 no 3158 0.0640708732885345 4469 27209819
SGTC_2160 5660466 132.927 µM -1.52390203363269 0.058374004662898 no 3159 0.0637665926961758 4437 2859134
SGTC_2082 5219693 150 µM -1.5257767967694 0.0581537439949563 no 3160 0.0635327305920327 4465 2834649
SGTC_2968 9090663 33.37 µM -1.52921070993928 0.0577519971170546 no 3161 0.0631061081999521 4450 25236811
SGTC_571 k831-0106 44.2 µM -1.53097234401888 0.0575467452922981 no 3162 0.0628881139444897 4407 4783639
SGTC_3058 9093861 49.47 µM -1.5330249891924 0.0573083113864588 no 3163 0.062634848958782 4517 17217477
SGTC_2236 dapsone 200 µM -1.53599265216158 0.0569649648511825 no 3164 0.0622700912409068 4542 2955 A bacterial DFR inhibitor. An anti-cancer agent.
SGTC_426 0988-0037 14.6 µM -1.54120802750795 0.0563654937228196 no 3165 0.0616330821972416 4526 5383008
SGTC_1114 scopoletin 1.73284 µM -1.54320108439392 0.056137723224366 no 3166 0.0613909971470643 4547 5280460 A coumarin with genotoxic properties.
SGTC_1864 st057645 30.4 µM -1.54348861281082 0.0561049238962241 no 3167 0.0613561341326817 4553 688666
SGTC_464 bw-b 70c 158 µM -1.55578287425338 0.0547165612010108 no 3168 0.0598798659169448 4520 5353454
SGTC_1262 0737-0114 49.6 µM -1.55587248635799 0.054706542144595 no 3169 0.0598692085435639 4533 765919
SGTC_2438 5259590 200 µM -1.55729441828531 0.0545477574638532 no 3170 0.0597003000174502 4534 1201127
SGTC_2058 5236698 133 µM -1.55781441539666 0.0544897813806833 no 3171 0.0596386238951886 4489 766665
SGTC_1847 st056231 15 µM -1.55870622257037 0.054390464521659 no 3172 0.0595329641648575 4501 5393180
SGTC_1619 st003326 88.7 µM -1.56168035194134 0.0540602828634289 no 3173 0.0591816548496459 4497 2849032
SGTC_2377 9073351 62.6 µM -1.56699640399295 0.0534740600641991 no 3174 0.0585577660781116 4528 7337946 YHR072W ERG7
SGTC_3305 9127027 53.8275 µM -1.56817484326056 0.0533447932833895 no 3175 0.0584201668391286 4480 41905295
SGTC_73 0327-0325 16.231 µM -1.57372844438456 0.0527389315415884 no 3176 0.0577751214616097 4341 53298
SGTC_446 go6976 132 µM -1.58113055381495 0.0519399121551447 no 3177 0.056924094977798 4538 3501 A protein kinase C inhibitor.
SGTC_986 1493-0483 84 µM -1.58132287884663 0.0519192805881614 no 3178 0.0569021154971796 4497 40079
SGTC_1184 1269-1718 139 µM -1.5902768072516 0.0509659407070704 no 3179 0.0558862120425366 4591 5403821
SGTC_1622 st003707 19.4 µM -1.59183286058939 0.0508016952616811 no 3180 0.0557111322439406 4549 10140899
SGTC_528 3492-0019 172 µM -1.59412769924833 0.0505602385391769 no 3181 0.055453718024302 4537 2869262
SGTC_932 2857-0803 154 µM -1.59817998140198 0.0501361016187836 no 3182 0.0550014637927577 4542 674898
SGTC_3211 9128781 49.47 µM -1.60052620925384 0.0498918304682036 no 3183 0.0547409486965482 4462 17194361
SGTC_110 0850-0284 111.64 µM -1.60133446559554 0.049807901210703 no 3184 0.0546514296154237 4471 3906265
SGTC_938 3126-1755 342 µM -1.60654191785462 0.0492698570239343 no 3185 0.0540774462661737 4538 1777771
SGTC_2397 5161689 200 µM -1.60973867125962 0.0489418678286346 no 3186 0.0537274594269669 4555 2259942
SGTC_1128 3448-9350 235 µM -1.61207402270198 0.0487033636392325 no 3187 0.0534729164043523 4535 619386
SGTC_1871 st057448 67.3 µM -1.61455232479409 0.0484512772624444 no 3188 0.0532038384466812 4539 691747
SGTC_2814 7977482 42.97 µM -1.61613355988161 0.0482909841882957 no 3189 0.0530327198702881 4539 6456762
SGTC_2025 5147754 141 µM -1.61730890421652 0.0481721121736488 no 3190 0.0529058091025543 4538 315777 YLR208W SEC13
SGTC_1971 st069429 63.5 µM -1.61781014815845 0.0481214886133928 no 3191 0.0528517593500014 4547 1246522 YGL099W LSG1
SGTC_1233 0325-0408 14.2 µM -1.62196908745492 0.0477030931531039 no 3192 0.0524049835985032 4584 12874
SGTC_1163 k060-0048 49.9 µM -1.6262860325651 0.0472718885732721 no 3193 0.0519444108347131 4564 6809982
SGTC_2418 pentamidine 31.67 µM -1.62722074727604 0.0471789358591206 no 3194 0.0518451114284644 4508 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_2257 7960413 200 µM -1.6345599421625 0.0464541713154835 no 3195 0.0510706654085289 4598 2974689 YIL048W NEO1
SGTC_245 methotrexate 289.6 µM -1.63747532226995 0.0461687616990484 no 3196 0.0507655955784674 4518 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2
SGTC_1483 3453-0561 55.9 µM -1.63813580930711 0.0461042974658801 no 3197 0.050696683224853 4592 4546991
SGTC_2660 2',4'-dihydroxychalcone 17.14 µM -1.64569425250807 0.0453717214951564 no 3198 0.0499133614667251 4592 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_564 3555-0129 330 µM -1.65488070806374 0.0444939924841739 no 3199 0.0489743491470191 4483 563260
SGTC_1359 1582-0056 520 nM -1.65510830003555 0.0444724218824949 no 3200 0.0489512657758671 4610 3661189
SGTC_167 3672-0051 66.205 µM -1.67601384734325 0.0425267024553417 no 3201 0.0468677401481023 4497 3237971
SGTC_2722 naftopidil 47.16 µM -1.68052611161105 0.0421159041494824 no 3202 0.0464274991467302 4520 4418 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_3348 9149464 3.537 µM -1.68483857074666 0.0417263033396356 no 3203 0.0460098605151874 4536 1951442
SGTC_1238 0333-0287 48.8 µM -1.68582648713531 0.0416374641382691 no 3204 0.0459146122555437 4583 7226
SGTC_3030 9087619 49.47 µM -1.69886222237875 0.040479503176837 no 3205 0.0446725732252976 4584 25236973
SGTC_3298 9116858 71.43 µM -1.70070386608951 0.0403180386855545 no 3206 0.0444993043972188 4635 2506942
SGTC_152 4469-0003 551.229 µM -1.70096907257017 0.0402948300844148 no 3207 0.0444743974238429 4567 697280
SGTC_3245 9134821 49.47 µM -1.70206583820152 0.0401989657384674 no 3208 0.0443715134867372 4597 17014901
SGTC_2461 5755302 26.15 µM -1.70480341148844 0.0399604924527413 no 3209 0.0441155475322625 4583 2788904
SGTC_2436 5633522 8.09 µM -1.70541230512572 0.0399076076048858 no 3210 0.0440587774938928 4570 5724242
SGTC_449 xestospongin c 11.1929 µM -1.71522614790855 0.0390630564824154 no 3211 0.0431518863174606 4608 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1
SGTC_1958 st076513 41.9 µM -1.72045472409105 0.0386190759546542 no 3212 0.0426749084516537 4529 732122 YGL099W LSG1
SGTC_132 0417-1715 25.805 µM -1.72334986990505 0.038375010981832 no 3213 0.0424126372342898 4563 6769098
SGTC_942 3253-1115 227 µM -1.7244310192523 0.0382841916049759 no 3214 0.0423150308996867 4615 46497897
SGTC_1077 5-fluorocytosine 377 nM -1.72776586397399 0.0380051593683179 no 3215 0.0420151048731598 4632 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_2375 9072683 200 µM -1.72912795901166 0.0378916687633999 no 3216 0.0418930981050121 4631 16798029
SGTC_2955 9076254 12.21 µM -1.73436135288549 0.0374581889495968 no 3217 0.0414269938920478 4541 16459619
SGTC_474 dl-dihydrosphingosine 5 µM -1.7416150984012 0.0368640698007682 no 3218 0.0407879088077712 4582 3058739 A sphingolipid protein kinase C inhibitor.
SGTC_1363 1636-0063 10.4 µM -1.7632653326647 0.0351364819042739 no 3219 0.0389278746828457 4623 6072185
SGTC_2344 7990960 76.95 µM -1.76367176360182 0.0351046969963708 no 3220 0.0388936288516857 4595 140813
SGTC_443 clozapine 122 µM -1.76400459130456 0.0350786857996017 no 3221 0.0388656030979049 4603 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_421 streptovitacin 30 mM -1.77968195295355 0.0338712701394486 no 3222 0.0375640127986489 4590 91467 include heat shock
SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM -1.78178637205666 0.0337118289617078 no 3223 0.0373920377266347 4645 4174840
SGTC_303 1348-1668 34.2 µM -1.78255726673429 0.033653576950009 no 3224 0.0373292006630977 4644 5380509
SGTC_2847 9005661 71.43 µM -1.786101028791 0.033386860228123 no 3225 0.0370414508133478 4654 2991449
SGTC_2948 9070189 9.45 µM -1.80396454484433 0.0320687589983053 no 3226 0.0356184326509972 4567 6473636 YDL196W YDL196W
SGTC_3321 9137793 26.8275 µM -1.80415972621517 0.0320545978898078 no 3227 0.0356031354386985 4612 4904192
SGTC_60 0986-0278 202 µM -1.80439008142074 0.0320378914366843 no 3228 0.0355850884291119 4583 3110598
SGTC_27 0485-0001 32.618 µM -1.81264844858844 0.0314436882170791 no 3229 0.0349430301216982 4639 2054479
SGTC_1585 2',4'-dihydroxychalcone 10.4 µM -1.81857159517871 0.0310231428009309 no 3230 0.0344884073266348 4643 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_127 0180-0333 59.125 µM -1.82491447296945 0.0305779678502334 no 3231 0.0340069684077253 4560 771601
SGTC_1155 4088-0394 48.2 µM -1.82846123986068 0.030331353024673 no 3232 0.0337401788533215 4641 2326248
SGTC_2249 haloperidol 116.36 µM -1.8341245077913 0.0299409914851828 no 3233 0.0333177571150816 4563 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_3323 9138564 53.9225 µM -1.83958192624435 0.0295687701180556 no 3234 0.0329148199271451 4657 43912313 YNL103W MET4
SGTC_1132 3456-3614 2.5 µM -1.84338378990851 0.0293117416448578 no 3235 0.0326364975666715 4600 3125502
SGTC_888 0916-0002 6.97 µM -1.84529828677296 0.0291830144075375 no 3236 0.0324970797870871 4639 2802138 YIL048W NEO1
SGTC_89 0302-0250 142.109 µM -1.8482410576015 0.0289860638696691 no 3237 0.0322837391548471 4693 4203518 YLR208W SEC13
SGTC_2724 maprotiline 69.64 µM -1.84888511901433 0.0289431064931452 no 3238 0.0322372014497684 4571 4011 A tricyclic antidepressant.
SGTC_54 0159-0055 9 µM -1.8496128011512 0.0288946354873956 no 3239 0.0321846882275494 4613 3319099
SGTC_1227 3909-8010 46.6 µM -1.85546539308829 0.0285072420731545 no 3240 0.0317648983507773 4650 15982272
SGTC_2654 protoveratrine a 100 µM -1.85752446996352 0.0283719797499831 no 3241 0.0316182865582848 4674 5702278 A heart drug and vasodilator.
SGTC_3260 9137109 49.47 µM -1.85910376737651 0.0282685967787567 no 3242 0.0315062156935864 4649 17478346
SGTC_818 4072-2707 53.5 µM -1.86490532410312 0.0278915068238171 no 3243 0.0310973380202446 4590 882871
SGTC_1712 st032288 53.4 µM -1.87907740415732 0.0269879396409007 no 3244 0.0301169624770882 4445 2883011
SGTC_893 0958-0369 48.9 µM -1.88571710371576 0.0265730935287262 no 3245 0.0296665434043292 4520 6819948
SGTC_2805 7950783 58.44 µM -1.88763632368131 0.0264541785957163 no 3246 0.0295373950905513 4639 1178958 YDL195W SEC31
SGTC_709 3807-1509 243 µM -1.88888635427967 0.0263769660512705 no 3247 0.0294535291565226 4705 1886677 YPL242C IQG1
SGTC_806 3966-4455 5.86 µM -1.89333193668156 0.0261038934759663 no 3248 0.0291568702987385 4654 714982
SGTC_2326 6164455 177.58 µM -1.89500706215013 0.0260016130203958 no 3249 0.0290457330323802 4573 2888790
SGTC_2229 7354935 190 µM -1.9027480832427 0.0255333028864904 no 3250 0.0285367122544844 4653 318112
SGTC_2334 9017922 200 µM -1.90570472342135 0.0253563082307011 no 3251 0.0283442630678029 4653 3163164
SGTC_3152 9099253 49.47 µM -1.91431076986954 0.0248469610150639 no 3252 0.0277902295683053 4509 25236131
SGTC_1370 2001-0092 44.6 µM -1.91527759490549 0.024790279563807 no 3253 0.0277285556740073 4624 790957
SGTC_1283 0922-0125 16.4 µM -1.92569066917874 0.0241866441130626 no 3254 0.0270715048331797 4659 3360884
SGTC_1874 staurosporine 7.6 µM -1.93433549290201 0.0236949363607358 no 3255 0.0265359460198272 4658 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1
SGTC_2598 perillyl alcohol 100 µM -1.93818586139652 0.0234786527337033 no 3256 0.0263002755309998 4651 10819 An apoptosis inducer.
SGTC_391 gliotoxin 8.33 µM -1.93963530937359 0.0233976655124723 no 3257 0.0262120132686107 4686 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion
SGTC_816 0325-0417 81.3 µM -1.94644927999491 0.023020081480642 no 3258 0.0258003974466769 4677 68101
SGTC_503 tyrphostin 8 294 µM -1.95239937921323 0.0226945770605205 no 3259 0.0254454033490575 4678 92970 A tyrosine kinase inhibitor. YOR207C RET1
SGTC_3153 9100258 49.47 µM -1.95266574294508 0.0226800966245696 no 3260 0.0254296077310266 4599 25236848
SGTC_1360 1598-0022 39.8 µM -1.9569494498843 0.0224482874259391 no 3261 0.0251767059299301 4674 761525
SGTC_1443 4112-3303 14 µM -1.95737921929456 0.0224251414958111 no 3262 0.0251514499190535 4712 704433
SGTC_1035 k081-0041 55.2 µM -1.96261007016395 0.0221450351978282 no 3263 0.0248457498555353 4663 731709
SGTC_1525 8-methoxypsoralen 92.5 µM -1.97278936761593 0.0216084042136458 no 3264 0.0242597825186456 4681 4114 Related to psoralen; DNA damaging agent.
SGTC_2028 5153890 36.43 µM -1.98295415299816 0.0210835449427094 no 3265 0.0236862754480067 4665 2830968 YPR165W RHO1
SGTC_1979 st071809 45.3 µM -1.98605472293402 0.0209256097090708 no 3266 0.02351362397847 4708 4976333
SGTC_315 k915-0449 187 µM -1.9881980470645 0.0208170205007588 no 3267 0.023394895447936 4700 20970215 YNL149C PGA2
SGTC_2481 5478948 45.16 µM -2.02862036988711 0.0188567162065905 no 3268 0.0212484860852819 4671 77792
SGTC_3194 9111903 49.47 µM -2.02903799053759 0.0188373127596857 no 3269 0.0212272104814998 4661 17087251
SGTC_899 1083-0020 478 µM -2.03048953245019 0.0187700034503915 no 3270 0.0211534020527804 4717 767123
SGTC_90 0870-0863 4.608 µM -2.03201285028765 0.0186995860289336 no 3271 0.021076177527571 4713 1738164
SGTC_2677 mitomycin C 100 µM -2.03287268539467 0.0186599383569711 no 3272 0.0210326936431743 4737 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_1118 chelidonine 707.474 nM -2.04958760649371 0.017903299261499 no 3273 0.0202023454245822 4678 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor.
SGTC_2816 7982706 58.44 µM -2.06056134354014 0.0174209069588544 no 3274 0.0196724539360443 4663 2981853
SGTC_2994 9053520 71.4286 µM -2.07140230376642 0.0169552938055278 no 3275 0.0191606078963025 4692 4647384
SGTC_718 1130-0073 349 µM -2.07246231422126 0.0169103433220658 no 3276 0.0191111736255026 4702 6740020
SGTC_1275 0867-0008 21.1 µM -2.07268139979775 0.0169010655628224 no 3277 0.0191009699618662 4682 3422836
SGTC_306 1672-3436 11.6 µM -2.07760104030731 0.0166938737056718 no 3278 0.0188730601476498 4719 6797378
SGTC_988 1497-1057 103 µM -2.08463282106751 0.0164015037037798 no 3279 0.0185513214392972 4702 3533044
SGTC_2183 6420625 130.508 µM -2.08890471510782 0.0162260348712415 no 3280 0.0183581506630148 4728 2897619
SGTC_252 miconazole 1.30953 nM -2.09536303332724 0.0159638125465934 no 3281 0.018069366523408 4637 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_2118 5526350 200 µM -2.10315785689208 0.015652170862092 no 3282 0.0177259864118945 4703 743594
SGTC_2973 9094665 17.96 µM -2.10585854107175 0.0155454203865412 no 3283 0.0176083209477066 4664 25237061 YIL048W NEO1
SGTC_1422 4031-0024 15.5 µM -2.11514212216143 0.0151832189028956 no 3284 0.0172089180441891 4687 782427
SGTC_388 3',4'-dichloroisocoumarin 16.7 µM -2.1198019918248 0.0150041619988556 no 3285 0.0170113736341279 4718 1609 A potent and irreversible inhibitor of serine proteases.
SGTC_312 4092-0653 6.84 µM -2.13465447685452 0.014445511974968 no 3286 0.0163946220283658 4613 1148278
SGTC_634 1611-4317 11.2 µM -2.14327771120261 0.0141294533284146 no 3287 0.0160454027338879 4735 2843522
SGTC_2975 9084847 53.72 µM -2.15170462629337 0.0138263650306601 no 3288 0.0157103127738247 4682 27211724
SGTC_183 3914-0051 30.55 µM -2.15255113251294 0.0137962312166402 no 3289 0.0156769863057111 4696 1596232
SGTC_1567 st069303 68.4 µM -2.15751361690408 0.0136207143442392 no 3290 0.0154828336533184 4698 5581319
SGTC_2793 7325131 81.82 µM -2.16475292418443 0.0133681263462574 no 3291 0.0152033058461555 4689 4176441
SGTC_1818 st052136 56.3 µM -2.16598895444722 0.0133254065518719 no 3292 0.0151560155002411 4447 674169
SGTC_799 1310-0557 151 µM -2.17963414971453 0.0128615816643669 no 3293 0.0146422956606236 4725 5354492
SGTC_2254 7938975 95.19 µM -2.18149481929757 0.0127994287967512 no 3294 0.0145734186151271 4720 2969277
SGTC_2862 9027634 71.43 µM -2.18933378691425 0.0125404246490417 no 3295 0.0142862941724696 4697 5012562
SGTC_3062 9077494 49.47 µM -2.19685626284792 0.0122961563912069 no 3296 0.0140153566731605 4666 16459633
SGTC_1754 st042065 16.137 µM -2.20471158336319 0.012045490585811 no 3297 0.0137371698915668 4539 1126236 YIL048W NEO1
SGTC_1785 bathophenanthroline 24 µM -2.20853374734869 0.0119251348201859 no 3298 0.0136035439978039 4662 72812 An iron chelator.
SGTC_1800 st050079 29.0735 µM -2.21175618268311 0.0118244756579283 no 3299 0.0134917580980914 4586 3645560
SGTC_1295 1013-0063 9.78 µM -2.21712715071503 0.0116583408696776 no 3300 0.0133072019672746 4733 6826038
SGTC_1039 k821-0043 94 µM -2.22662933605951 0.0113693796411738 no 3301 0.0129860283308072 4695 15992768
SGTC_734 2023-0417 80 µM -2.22982254707719 0.0112736812668374 no 3302 0.0128796129624277 4727 3935732
SGTC_649 1123-0311 367 µM -2.23038518217052 0.0112568922213567 no 3303 0.0128609412221286 4643 693629 YIL048W NEO1
SGTC_1312 1218-2183 165 µM -2.24137838870017 0.0109331881618824 no 3304 0.0125007875895025 4758 6744073
SGTC_2683 piperine 63.03 µM -2.24174164549776 0.0109226314496024 no 3305 0.012489037323847 4758 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_3037 9091026 49.47 µM -2.25184382645456 0.0106325811897913 no 3306 0.0121660715040041 4626 25236398 YIL048W NEO1
SGTC_1574 spiramycin 23.7 µM -2.2695566119929 0.0101401900089705 no 3307 0.0116172493368046 4716 6419898 An antibiotic and protein synthesis inhibitor.
SGTC_2407 paclitaxel 400 µM -2.29119009225473 0.00956588903102637 no 3308 0.0109762108737766 4725 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_53 0973-0023 39.979 µM -2.30546167827625 0.00920277541023598 no 3309 0.0105703653033328 4684 674768
SGTC_2891 9063876 19.48 µM -2.31888512812743 0.00887230999803526 no 3310 0.0102006328597057 4760 6472478
SGTC_1234 0326-0494 15.5 µM -2.33108640375983 0.00858100236822769 no 3311 0.00987440203785561 4766 1547813
SGTC_2584 androsterone 48.74 µM -2.34988587250519 0.00814858075558975 no 3312 0.00938958401308105 4661 2754130 A steroid.
SGTC_1382 3002-2117 298 µM -2.3520580366583 0.00809987247394793 no 3313 0.00933493085248747 4765 1497314
SGTC_1884 5633444 25 µM -2.35384820041626 0.00805992263830633 no 3314 0.00929009848966483 4702 5724239
SGTC_1009 4106-0057 9.87 µM -2.38352618872509 0.00742240420185714 no 3315 0.00857383216169706 4740 2928005
SGTC_1573 oleylamine 1.06 µM -2.39064913795129 0.00727617235129998 no 3316 0.00840930843774348 4740 5356789 An amine of the fatty acid oleic acid.
SGTC_2965 9082772 38.63 µM -2.40551518374847 0.0069791360512556 no 3317 0.00807484041643515 4733 16459634
SGTC_3072 9116419 49.47 µM -2.40587167983631 0.00697214633711145 no 3318 0.00806696532878956 4733 17170162
SGTC_2974 9094440 9.66 µM -2.41158845303318 0.00686090035047165 no 3319 0.00794159931888422 4718 25236134
SGTC_999 SEC7.066 22.7 µM -2.41595712960307 0.00677694746546432 no 3320 0.00784695449790862 4743 740511 YDR170C SEC7
SGTC_3173 9105693 49.47 µM -2.50128394063037 0.00530954663260074 no 3321 0.00618719611547652 4745 17096658
SGTC_2269 7935389 174.42 µM -2.50495576330865 0.00525328629443384 no 3322 0.00612333546402416 4753 97605
SGTC_3082 9117008 49.47 µM -2.56376696277195 0.00442168606013849 no 3323 0.00517715193653278 4772 41448529
SGTC_1841 st054148 70 µM -2.56655547731169 0.00438535211765584 no 3324 0.00513570965957722 4765 675442
SGTC_375 3970-0961 9.27 µM -2.56964212633076 0.00434544481233532 no 3325 0.00509018112415322 4761 2898222
SGTC_656 4090-1979 187 µM -2.57196104201 0.0043156773798336 no 3326 0.00505621351812023 4779 22330961
SGTC_3282 9108498 15.4605 µM -2.63042969574398 0.00362291562602261 no 3327 0.00426385029039307 4754 16459645
SGTC_514 4466-0038 2.65 nM -2.64542314499757 0.00346216566691083 no 3328 0.00407944093432481 4657 5722064
SGTC_3033 9090887 49.47 µM -2.65778659165815 0.00333446463046678 no 3329 0.00393278412355646 4765 19325384
SGTC_710 3448-4187 58 µM -2.66423349730462 0.00326956897604851 no 3330 0.0038581990560908 4751 3946412
SGTC_840 0245-0196 390 µM -2.67071153774029 0.00320550631183944 no 3331 0.00378453310599162 4797 3827528
SGTC_1941 st076221 61.8 µM -2.70119538321565 0.00291895187817098 no 3332 0.00345453687653849 4717 2828568
SGTC_358 0075-0058 9.45 µM -2.71599639089863 0.002788327548759 no 3333 0.00330383191795021 4736 1069125
SGTC_725 1497-0963 19 µM -2.74766779075559 0.00252637275223169 no 3334 0.00300103946173974 4791 3549977
SGTC_859 0439-0102 54.6 µM -2.75433874327037 0.00247411850951597 no 3335 0.00294054316862388 4782 610143
SGTC_638 3970-0837 4.09 µM -2.75954502783658 0.00243401844455819 no 3336 0.00289409549471551 4786 4118451 YLR208W SEC13
SGTC_704 1310-0270 142 µM -2.78937534150517 0.00221538373503267 no 3337 0.00264049111185592 4765 5718033
SGTC_842 0271-0008 11.1 µM -2.88997426666141 0.00160294505121074 no 3338 0.00192636681591549 4794 1221709
SGTC_2594 a-mangostin 100 µM -2.91852607268223 0.00145974683872104 no 3339 0.00175845231563353 4765 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis.
SGTC_740 k014-0057 261 µM -2.93912606905587 0.00136378912197633 no 3340 0.00164569582377002 4790 4012779
SGTC_696 1560-0013 611 µM -2.96503966593518 0.00125127284793903 no 3341 0.00151321952322722 4791 1650269
SGTC_1365 1672-3266 55.4 µM -3.01819719220845 0.00104659063118328 no 3342 0.00127141691821773 4793 6415873
SGTC_1418 3966-3099 2.4 µM -3.06909055562852 0.000879861888355795 yes 3343 0.00107355748928119 4797 740335
SGTC_2899 9053889 58.44 µM -3.09643000015293 0.000800735603002679 yes 3344 0.00097933050518035 4801 6470052
SGTC_2506 ethyl hematommate 54.16 µM -3.12968543387574 0.000713331751284878 yes 3345 0.000874967925591261 4794 3940691 An allergen.
SGTC_2868 9035608 32.47 µM -3.14331152886557 0.000680129299180878 yes 3346 0.000835239757646274 4793 6462614
SGTC_856 0433-0016 11.3 µM -3.3500342452319 0.000322928480833253 yes 3347 0.000404007850154663 4804 3911780
SGTC_2117 5521686 200 µM -3.44341132629321 0.000227594396309537 yes 3348 0.000287212465567991 4803 803312
SGTC_1388 3346-4487 254 µM -3.44980329488547 0.000222140375416825 yes 3349 0.000280497581372069 4806 3345614
SGTC_1920 st075728 45.7 µM -3.51060397023591 0.000176024955092788 yes 3350 0.000223544965657364 4799 3400306
SGTC_1386 3228-0095 33.8 µM -5.18929753001851 6.9012620071012e-08 yes 3351 1.05544442189237e-07 4805 870181