SGTCid condition conc unit KEX1|YGL203C.score KEX1|YGL203C.strain.pval KEX1|YGL203C.strain.significant KEX1|YGL203C.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene SGTC_2021 4019055 173 µM 9.8343418880337 4.37084677310406e-24 yes 1 4.0044759185457e-23 11 44827708 YER133W GLC7 SGTC_1712 st032288 53.4 µM 9.09220513736394 7.35617928161293e-21 yes 2 4.85251858853307e-20 32 2883011 SGTC_351 caspofungin 25 nM 6.8195329978366 1.60514369079895e-12 yes 3 4.56684666361881e-12 30 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1 SGTC_528 3492-0019 172 µM 6.46336946661147 2.00725832851563e-11 yes 4 5.11984341081949e-11 108 2869262 SGTC_2419 paclitaxel 166.5 µM 6.18238791084863 1.34332102459319e-10 yes 5 3.15695705693294e-10 4 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_1228 0124-0032 52.5 µM 5.80710065892659 1.49976787176465e-09 yes 6 3.17819627472953e-09 2 X1228 SGTC_1512 0259-0544 12.2 µM 5.70309268502541 2.85331157244465e-09 yes 7 5.88264828808037e-09 1 18476 SGTC_1431 4049-0260 9.09 µM 5.16595078639305 6.63107991002442e-08 yes 8 1.19609866660579e-07 2 3854841 SGTC_320 4092-0846 5.34 µM 4.85318969109518 3.61712545546318e-07 yes 9 6.07456899907416e-07 27 1359356 SGTC_1019 4262-0212 3.4 µM 4.81535846127919 4.41124996749827e-07 yes 10 7.34679410911165e-07 35 4677213 SGTC_1563 conessine 56.1 µM 4.73843863717945 6.57478322005929e-07 yes 11 1.07685612464145e-06 6 441082 An anti-amoebic, histamine inhibitor. SGTC_1572 epiandrosterone 68.9 µM 4.60918551156807 1.26842903331367e-06 yes 12 2.02124755773664e-06 20 441302 A steroid. SGTC_447 ml7 120 µM 4.14287114424114 1.18040149836512e-05 yes 13 1.714923371662e-05 25 4216 Selective myosin light chain kinase inhibitor. SGTC_1439 4092-1168 46 µM 4.05643602824046 1.74247880898946e-05 yes 14 2.4913600789208e-05 8 2886240 SGTC_1803 st050068 52.4 µM 3.96901050945673 2.56410992779019e-05 yes 15 3.60858495709389e-05 178 3984059 YIL048W | YNL267W NEO1 | PIK1 SGTC_1687 st020778 55.3625 µM 3.86869427416264 3.95687815911714e-05 yes 16 5.47098678584004e-05 179 4259299 SGTC_346 4513-0042 7.16 µM 3.70603159226299 7.82707970763568e-05 yes 17 0.000105266024938653 50 2827372 SGTC_1412 3909-8563 178 µM 3.69238975328227 8.27798385539449e-05 yes 18 0.00011107832727126 13 23767530 SGTC_1376 2910-0861 41.3 µM 3.33621041419333 0.000334698091386211 yes 19 0.000424644287304446 40 1112859 SGTC_1801 st050089 28.441 µM 3.30620242719522 0.000374353187172061 yes 20 0.000472848700430681 165 5008493 YIL048W | YNL267W NEO1 | PIK1 SGTC_1465 k213-0056 144 µM 3.23595090601647 0.000484862485106885 yes 21 0.000606191170076827 45 24048857 YMR208W ERG12 SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM 3.14944825827948 0.000662288807322303 yes 22 0.000817895362206738 57 688761 SGTC_2014 4013930 200 µM 3.08946586611357 0.000818623454210537 yes 23 0.00100258373099546 79 64556 SGTC_2386 9075165 157.42 µM 3.06143563159755 0.000902753216043052 yes 24 0.00110139174363343 28 16452277 SGTC_2948 9070189 9.45 µM 3.05464823540881 0.000924285964609811 yes 25 0.00112662316087675 69 6473636 YDL196W YDL196W SGTC_2930 9013230 14.89 µM 3.04069260309347 0.000970049583420057 yes 26 0.00118017336926603 87 2995857 SGTC_1569 carminic acid 40.6 µM 3.0396639695823 0.000973503688357549 yes 27 0.00118421119489339 50 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_3344 9148862 3.898 µM 3.00752042952603 0.00108729926844318 no 28 0.00131694210238854 48 4905352 SGTC_2404 5161160 200 µM 2.99597659449156 0.00113105753999026 no 29 0.00136783715343707 67 2831543 SGTC_1725 st036284 20.55 µM 2.97949297303624 0.0011963409899966 no 30 0.00144362926067976 75 707914 SGTC_3068 9116768 49.47 µM 2.94088767151956 0.00136295270283346 no 31 0.00163636595060005 65 41904888 SGTC_2537 larixol 68.93 µM 2.91366676098129 0.0014928940675291 no 32 0.00178605496541757 85 6708759 SGTC_308 4092-1169 104 µM 2.89020724228331 0.00161384244971117 no 33 0.00192493966081865 111 2268590 YDL196W YDL196W SGTC_2216 7189485 200 µM 2.8699709907885 0.00172527414800729 no 34 0.00205254729218228 22 731273 SGTC_256 clotrimazole 625 nM 2.86589015371581 0.00174857672957773 no 35 0.00207919254509711 90 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C SGTC_2343 7990716 14.84 µM 2.79754501821453 0.00218385448994946 no 36 0.00257462954184725 69 6456862 SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM 2.79459399757714 0.00220469118951114 no 37 0.00259824656949867 78 5024745 SGTC_377 3970-0964 33.1 µM 2.79320547271989 0.0022145575469052 no 38 0.00260942651236451 132 16481235 SGTC_3200 9114385 49.47 µM 2.77185982131259 0.0023713522541283 no 39 0.00278685166000301 106 17018030 YLR208W SEC13 SGTC_1477 0139-0234 16 µM 2.73566972017897 0.00266028497735672 no 40 0.00311267371171787 64 620880 SGTC_1597 7-benzyloxygramine 47.5 µM 2.72241022206003 0.00277386181840406 no 41 0.00324038198280752 270 260807 SGTC_2975 9084847 53.72 µM 2.6883743183504 0.00308569942660912 no 42 0.00359004294816421 109 27211724 SGTC_488 nitrendipine 139 µM 2.67099418983795 0.00325681492034465 no 43 0.00378134779227704 115 4507 Dihydropyridine L-type calcium channel blocker. SGTC_2394 5221648 200 µM 2.66521547314012 0.00331557178851522 no 44 0.00384695038359334 109 788586 SGTC_162 k030-0015 37.8 µM 2.66008861772781 0.00336849669993537 no 45 0.00390600471838763 74 1809920 YMR134W ERG29 SGTC_2372 9071633 200 µM 2.65431674297383 0.00342898785190384 no 46 0.00397345960704215 78 21321366 SGTC_2427 5545055 42.75 µM 2.6527469381006 0.003445607878205 no 47 0.0039919851981398 98 5372858 SGTC_996 3970-0799 1.8 µM 2.65116566760269 0.00346242242491214 no 48 0.0040107242540029 200 6615648 YGL040C HEM2 SGTC_1495 4469-0029 237 µM 2.63179613966043 0.00367445337191034 no 49 0.00424674049212557 226 793680 SGTC_312 4092-0653 6.84 µM 2.62379430497318 0.0037653950528746 no 50 0.0043478141448993 184 1148278 SGTC_2953 9074162 66.49 µM 2.61410751019957 0.00387818354767295 no 51 0.00447304405374697 86 16451992 SGTC_2013 4024628 200 µM 2.59340565446374 0.00412943080001994 no 52 0.0047515304249309 137 5230760 SGTC_1529 apigenin 74 µM 2.59167006757603 0.00415114229828721 no 53 0.00477556604268911 133 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_1316 1272-0050 65.9 µM 2.58780108673147 0.00419990970055728 no 54 0.00482953700948351 71 7340392 SGTC_1998 st075797 76.8 µM 2.571566220222 0.00441017872979828 no 55 0.00506198259400773 103 24208315 SGTC_897 1000-0139 31.4 µM 2.55773215221818 0.00459672219375438 no 56 0.00526786038440564 81 6151020 SGTC_1452 4194-0072 190 µM 2.55412114315484 0.00464655917338968 no 57 0.00532281053875798 104 1343545 SGTC_1893 st059353 36.1 µM 2.55334445490183 0.00465734135285347 no 58 0.00533469610867444 117 3112488 SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM 2.53411602312456 0.00493149105650115 no 59 0.00563656997246333 134 5379071 SGTC_260 nsc-65238 3.989 µM 2.5249989458929 0.0050664331354436 no 60 0.00578493181668323 90 3246252 SGTC_521 r062-0005 13.8 µM 2.5067687846298 0.00534615568964525 no 61 0.00609201914636573 93 2832033 SGTC_2690 usnic acid 100 µM 2.48690670023215 0.00566647392183015 no 62 0.0064429594141609 142 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_1706 st031321 9.9705 µM 2.48221478260089 0.00574458512298667 no 63 0.00652842739625343 77 6103185 SGTC_2409 alverine citrate 63.97 µM 2.46872620019433 0.00597449217757725 no 64 0.00677974616357198 166 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_2940 9060638 45.86 µM 2.46652797189801 0.00601272333047233 no 65 0.0068215036089838 145 4027022 SGTC_515 4092-1064 102 µM 2.45826290601111 0.00615841536639641 no 66 0.00698054638725781 178 717353 SGTC_2217 6934799 96.0675 µM 2.45781620188829 0.00616637795529782 no 67 0.00698923469984874 70 675606 SGTC_2284 7945075 39.21 µM 2.45533335269829 0.00621080166531105 no 68 0.00703769985011429 139 1245402 SGTC_1800 st050079 29.0735 µM 2.45347316058871 0.00624427014770663 no 69 0.00707420486203845 320 3645560 SGTC_2281 7943571 200 µM 2.44051614910694 0.00648185516321684 no 70 0.00733314509750501 96 1244024 SGTC_1736 st036774 51 µM 2.42685044529709 0.00674106639626514 no 71 0.00761526641381649 132 1272247 SGTC_1125 tnp00248 1.32998 µM 2.4247533108038 0.00678164521988818 no 72 0.00765939607523968 187 24207736 SGTC_201 4262-0159 12.803 µM 2.41279720110345 0.00701714007626792 no 73 0.00791531256670204 125 1341029 SGTC_1297 1068-0111 14.1 µM 2.41114257743048 0.00705029273119516 no 74 0.00795131517962482 110 767057 SGTC_445 e6 berbamine 66 µM 2.41044450646823 0.00706432094975183 no 75 0.00796654750099618 275 6610268 A calcium/calmodulin antagonist. SGTC_2206 7254556 146.969 µM 2.40439200897641 0.00718698630502832 no 76 0.00809969582531877 67 4398905 SGTC_555 4296-0685 37 µM 2.40369083533422 0.00720131764748706 no 77 0.00811524658587426 99 2908540 YHR072W ERG7 SGTC_2110 5483698 200 µM 2.36917910211899 0.00793859065417518 no 78 0.00891380901981439 125 2848765 YHR062C RPP1 SGTC_1359 1582-0056 520 nM 2.36177604826271 0.00810512566629888 no 79 0.00909381278326624 142 3661189 SGTC_2224 6650123 117.647 µM 2.356649090979 0.00822225095411796 no 80 0.00922033173756478 62 2908370 SGTC_643 k048-0106 28.4 µM 2.32519088620463 0.00897399095053783 no 81 0.0100308777333902 110 6763920 SGTC_1244 0416-0015 52.5 µM 2.29995318657912 0.00961994635426811 no 82 0.0107254361786083 176 96201 SGTC_2050 5263056 171 µM 2.29566497244371 0.00973365076080568 no 83 0.0108475223481242 189 763468 YGL055W OLE1 SGTC_2429 5902844 64.44 µM 2.27157845964369 0.0103943883539866 no 84 0.0115559915631504 186 1927790 YGL093W | YPR107C SPC105 | YTH1 SGTC_2344 7990960 76.95 µM 2.26123856583287 0.0106898169875937 no 85 0.0118722440801886 155 140813 SGTC_2941 9056145 11.23 µM 2.2587390763349 0.0107623196820367 no 86 0.0119498101114218 102 2119517 SGTC_912 3474-0017 2.18 µM 2.25631156191969 0.0108331440281956 no 87 0.0120255629053916 157 3360550 SGTC_2480 5767542 37.17 µM 2.25493489604513 0.010873489167851 no 88 0.0120687077759562 122 2867358 SGTC_2408 sulbentine 18.36 µM 2.25366176926814 0.0109109162696738 no 89 0.012108727100014 195 67686 An antifungal agent of unknown mechanism. YDL205C HEM3 SGTC_2162 5663267 200 µM 2.24952847822393 0.0110331996936726 no 90 0.0122394465331643 126 6456493 SGTC_1546 5-methoxyflavanone 78.7 µM 2.24949782807691 0.0110341109131718 no 91 0.0122404204242657 126 147795 SGTC_1916 st067606 49.2 µM 2.24933910279781 0.0110388308145503 no 92 0.0122454649046794 204 19590279 SGTC_2222 6885208 172.143 µM 2.24782923848338 0.011083816460165 no 93 0.0122935403489981 75 609514 SGTC_2227 7312221 64.1025 µM 2.24651883722176 0.0111229883580471 no 94 0.0123353971735019 69 887188 YOR168W | YOR169C GLN4 | YOR169C SGTC_3209 9113616 49.47 µM 2.2317129496371 0.0115740138023902 no 95 0.0128169704120713 184 16649353 SGTC_1632 st005650 90 µM 2.23148311402522 0.0115811385657149 no 96 0.0128245724085711 163 2759605 SGTC_1046 2001-0062 216 µM 2.22707143552687 0.0117186379136605 no 97 0.0129712499541653 161 739778 SGTC_463 ikarugamyin 104 µM 2.22289852499976 0.0118499972850656 no 98 0.0131113216341362 60 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis. SGTC_2414 st077232 92.9 µM 2.19695533307876 0.0126956724806654 no 99 0.0140118182084804 180 729801 SGTC_1568 digitonin 820 nM 2.19633969045098 0.0127163593474376 no 100 0.0140338194311392 193 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1 SGTC_2521 angolensin 13.4 µM 2.19605101928278 0.0127260693365204 no 101 0.0140441459235901 137 821428 A flavenoid. SGTC_1777 st045864 34.765 µM 2.18927978840639 0.0129556794487803 no 102 0.0142882552337102 142 4691462 SGTC_1241 0364-0022 50.8 µM 2.18292176116271 0.0131745300522797 no 103 0.0145207860965603 190 4563895 SGTC_47 0149-0135 24.25 µM 2.1821059427632 0.0132028413983841 no 104 0.0145508573594585 169 5239155 SGTC_1503 4585-0012 61.3 µM 2.17958139681728 0.0132907839820407 no 105 0.0146442525088666 161 2922052 SGTC_2777 climbazole 1.536 µM 2.1613541097927 0.0139408757334822 no 106 0.0153339980435569 222 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2 SGTC_278 4092-0821 23.9 µM 2.15486213232785 0.0141789483974438 no 107 0.015586312213163 186 877900 SGTC_1951 sophoraflavanone G 9.2 µM 2.14719530493176 0.0144646084298225 no 108 0.0158888681714014 190 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity. SGTC_2349 9023730 187.07 µM 2.14440263124247 0.0145698852988182 no 109 0.0160003198097331 202 4126287 SGTC_3151 9099821 49.47 µM 2.12741518674255 0.0152245794299942 no 110 0.0166928007078099 177 17174189 SGTC_2821 7996764 71.43 µM 2.11046295040812 0.0159029503570836 no 111 0.0174092495945209 245 2987135 SGTC_642 0335-0876 158 µM 2.10802977083736 0.016002413809039 no 112 0.017514207184022 206 6812350 SGTC_2121 5257820 149.641 µM 2.08152386726367 0.0171209128219568 no 113 0.0186929909093605 202 791256 SGTC_877 0771-0151 33.1 µM 2.07849509966444 0.0172528763966865 no 114 0.0188318908879248 194 6166523 SGTC_1548 st061468 90.8 µM 2.07794485445923 0.0172769436491941 no 115 0.0188572192900231 146 390799 SGTC_1703 st026983 48.3 µM 2.06888913742918 0.0176771717462807 no 116 0.0192782455778231 190 1104023 SGTC_3062 9077494 49.47 µM 2.0592526908272 0.0181117284829171 no 117 0.0197350189764452 205 16459633 SGTC_3054 9094397 49.47 µM 2.05182019862357 0.0184530877343394 no 118 0.0200935697789582 246 2598354 SGTC_2934 9036370 36.88 µM 2.05161219811453 0.0184627190588436 no 119 0.0201036828861095 239 6462800 SGTC_252 miconazole 1.30953 nM 2.05013452959819 0.0185312648250058 no 120 0.0201756523401114 213 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_1333 1482-0047 286 µM 2.04988638949415 0.0185427967174684 no 121 0.0201877593371749 228 3811116 SGTC_2925 9010536 32.5 µM 2.04259558929939 0.0188843618341961 no 122 0.0205462440500974 283 2994177 SGTC_171 k064-0041 9.68 µM 2.04056191580183 0.0189805863479178 no 123 0.020647195444017 167 53325 SGTC_3197 9113331 49.47 µM 2.01885640481511 0.0200338321200661 no 124 0.0217510732500222 251 16610459 YLR208W | YDL195W SEC13 | SEC31 SGTC_1564 D-Arginine 115 µM 2.01467636578202 0.0202422587005347 no 125 0.0219692850688427 232 71070 D-isomer of arginine; arginine decarboxylase inhibitor. SGTC_2618 avocadyne 43.43 µM 2.0141648217539 0.0202678913029364 no 126 0.0219961158557667 191 3015189 SGTC_1842 st055362 61.2 µM 2.00143066981993 0.0209149028128217 no 127 0.0226729991323886 239 676032 SGTC_1028 k015-0029 4.8 µM 1.99328800404056 0.021337721844064 no 128 0.0231149596103747 262 4588309 SGTC_82 0054-0107 293.755 µM 1.98983855910518 0.0215190063503633 no 129 0.0233043611659635 173 3104697 SGTC_2280 7785178 200 µM 1.98513231601592 0.021768439740136 no 130 0.0235648761110183 187 2954328 SGTC_647 0140-0236 81 µM 1.97695206178966 0.0222078094559725 no 131 0.0240235245791055 239 990837 SGTC_663 1486-0733 13.9 µM 1.97589842232335 0.0222649417888683 no 132 0.0240831414641923 298 722445 YPR165W RHO1 SGTC_957 1187-1561 14.1 µM 1.97204175616982 0.0224751236577021 no 133 0.024302419984446 251 1538454 SGTC_562 3772-2733 112 µM 1.96667110132938 0.0227706007886841 no 134 0.0246105702929788 298 2876874 YIL048W NEO1 SGTC_63 0099-0242 26.702 µM 1.96505366983704 0.0228602257919614 no 135 0.0247040130468719 313 3898502 YLR359W ADE13 SGTC_3350 9150499 3.57 µM 1.95664689857859 0.0233308618668983 no 136 0.0251944985327501 293 4910996 YPR165W RHO1 SGTC_2111 5486399 200 µM 1.95416406353352 0.0234714084126415 no 137 0.0253409088751668 270 689674 SGTC_1131 3454-3128 32.3 µM 1.94799245313586 0.0238238552367481 no 138 0.0257079330889056 283 710982 SGTC_636 0kpi-0074 126 µM 1.94699368787 0.0238813086443698 no 139 0.025767745712464 210 616434 SGTC_253 dyclonine 31.25 µM 1.94697909835911 0.0238821487599903 no 140 0.0257686202905447 257 3180 An oral anasthetic. SGTC_2116 5511452 16.8835 µM 1.94058755232286 0.0242525934796498 no 141 0.0261541625665056 244 870744 SGTC_3074 9116018 49.47 µM 1.93840632193778 0.0243801137876979 no 142 0.0262868348724842 198 17027303 SGTC_2838 9002687 71.43 µM 1.93833193969622 0.0243844722705571 no 143 0.0262913690388688 231 6457060 SGTC_909 3448-9333 149 µM 1.92857151510951 0.024962093731542 no 144 0.026892039055159 214 3344074 SGTC_2438 5259590 200 µM 1.92523548966892 0.0251621318823253 no 145 0.0270999520213973 229 1201127 SGTC_2425 5628681 7.85 µM 1.92097145959732 0.0254197703758122 no 146 0.0273676528490349 278 5714958 SGTC_3042 9091578 49.47 µM 1.91946794648358 0.025511139996392 no 147 0.027462569541975 157 25236497 SGTC_1817 st052116 64.4 µM 1.90538609256914 0.0263803303039186 no 148 0.0283649508450883 225 4361398 SGTC_2529 gangaleoidin 93.61 µM 1.90153824518213 0.0266220958708266 no 149 0.0286157739982049 202 4565183 SGTC_2917 7979103 53.79 µM 1.8876300782156 0.027511452555055 no 150 0.0295378146028781 310 2980565 SGTC_311 1315-0136 58 µM 1.88368495393793 0.0277681866144455 no 151 0.0298038014140682 217 6759207 SGTC_2383 9036125 200 µM 1.87879273819146 0.0280893234942796 no 152 0.0301363994955847 191 79580 SGTC_811 0416-0114 265 µM 1.87746480259519 0.0281770240975997 no 153 0.0302272085179094 255 6612453 SGTC_3264 9137442 49.47 µM 1.87502636283782 0.0283386591292509 no 154 0.0303945484086452 199 17015726 SGTC_1729 st035615 45.989 µM 1.87293773120113 0.0284777195269119 no 155 0.03053849206941 269 17385451 SGTC_707 0865-0008 204 µM 1.86703227753368 0.0288739774776091 no 156 0.0309485402596773 224 723043 SGTC_2622 2-methoxyxanthone 59.94 µM 1.86064607208529 0.0293076413240818 no 157 0.0313970870401666 246 71034 A hepatoprotective. SGTC_51 1013-0126 23.419 µM 1.86044170979744 0.0293216076537467 no 158 0.0314115290892346 246 1627850 SGTC_2673 kobusone 100 µM 1.85801476089241 0.0294878908189507 no 159 0.0315834590874667 181 6710676 An epoxy ketone and protein crosslinker. SGTC_1185 1319-0113 81.3 µM 1.84672523281979 0.0302717192444332 no 160 0.0323934863716373 238 4672763 SGTC_1753 st043925 64 µM 1.84223606156959 0.0305881627425127 no 161 0.0327203138497485 279 670181 SGTC_2098 5376439 882.5 nM 1.83980741007719 0.0307604982686745 no 162 0.0328982585766467 268 2844116 SGTC_170 4197-0004 226 µM 1.82771966825631 0.0316302347356822 no 163 0.0337958173801678 224 218692 SGTC_2338 7999974 200 µM 1.82628078485054 0.0317351056824692 no 164 0.0339039890427587 287 315925 SGTC_2877 9040724 71.43 µM 1.82596191940745 0.0317583845754746 no 165 0.033927999058975 232 6463895 SGTC_1211 1056-0033 32.3 µM 1.82574916366449 0.0317739247350704 no 166 0.0339440269757926 239 6741922 SGTC_1905 st060207 84.5 µM 1.81594229702664 0.0324970880343087 no 167 0.034689612057895 233 1948547 SGTC_2722 naftopidil 47.16 µM 1.81415009263024 0.0326307024291215 no 168 0.0348273106355943 266 4418 An a1-adrenergic receptor antagonist or alpha blocker.  SGTC_2202 7226349 200 µM 1.81373110028413 0.0326620048617257 no 169 0.034859567274917 217 844334 SGTC_2909 7941780 10.49 µM 1.80924559947342 0.0329986654953088 no 170 0.0352064281593964 274 1243215 SGTC_3160 9100216 49.47 µM 1.80641104409032 0.033212884708602 no 171 0.035427078874839 241 17191039 SGTC_1458 k015-0034 6.33 µM 1.80564918203648 0.0332706567286898 no 172 0.0354865775856002 270 3598957 SGTC_6 0844-0013 19.835 µM 1.80558521910941 0.0332755108029016 no 173 0.0354915765880414 542 1584900 SGTC_1090 efavirenz 20.7 µM 1.80306785903906 0.0334670141028525 no 174 0.0356887790591048 277 64139 A non-nucleoside reverse transcriptase inhibitor. SGTC_761 k216-0224 480 µM 1.80144425122783 0.0335910075747066 no 175 0.0358164433722694 286 1340404 SGTC_2287 7945887 168.79 µM 1.7905802032337 0.0344304478854001 no 176 0.0366803431114049 265 1245853 SGTC_1391 3442-0225 151 µM 1.78578297002306 0.0348065665544978 no 177 0.0370672025800352 237 5227075 SGTC_1168 k815-0004 80.5 µM 1.78254389531987 0.0350624233520447 no 178 0.0373302898564251 264 642433 SGTC_1349 flufenamic acid 69 µM 1.78189751213256 0.0351136658953706 no 179 0.0373829731651786 261 3371 A non-steroidal anti-inflammatory. SGTC_2305 7443522 69.23 µM 1.78116906686296 0.0351714876049957 no 180 0.037442417693427 294 5415886 SGTC_1311 1190-0148 100 µM 1.77546019399846 0.0356273501592481 no 181 0.0379109662913847 363 1961333 SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM 1.77211715083426 0.0358965383590604 no 182 0.0381875562559616 205 4620898 SGTC_1504 k297-0033 30 µM 1.76731046286186 0.036286500066903 no 183 0.0385881242779422 233 4388117 SGTC_433 pimozide 108 µM 1.7668293053415 0.0363257261079191 no 184 0.0386284096409132 212 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic SGTC_2693 st077581 40.7 µM 1.76520454331098 0.0364584402942493 no 185 0.0387646976625686 387 25238761 SGTC_390 dec-rvkr-cmk 16.7 µM 1.75902309238375 0.0369669858522115 no 186 0.0392867931856038 314 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1 SGTC_261 5-fluorouridine 15.376 µM 1.75648987878893 0.0371770607011666 no 187 0.0395023990557145 297 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_3025 9087895 49.47 µM 1.7553464653169 0.0372722009396573 no 188 0.0396000315731126 305 17173641 SGTC_2465 5809242 33.21 µM 1.75173911018814 0.0375736633370884 no 189 0.0399093392714979 210 2731748 SGTC_1064 honokiol 6.76 µM 1.74874933942506 0.0378250210983463 no 190 0.0401671786449791 308 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis. SGTC_2604 4'-hydroxychalcone 11.32 µM 1.74576914582022 0.0380769377004852 no 191 0.0404255371930867 291 5282362 SGTC_1410 3909-8106 77.9 µM 1.7454339070822 0.0381053609591508 no 192 0.0404546839036307 249 1039210 SGTC_2830 7992007 71.43 µM 1.74013108240362 0.0385572679289717 no 193 0.0409180017712272 289 1952075 SGTC_1549 4'-methoxyflavonol 74.6 µM 1.73242145586444 0.039222064016996 no 194 0.041599275271891 284 97141 SGTC_313 3474-0040 5.03 µM 1.73146581436853 0.0393051143423402 no 195 0.0416843585061314 403 1043375 YIL048W NEO1 SGTC_392 N-ethylmaleimide 8.33 µM 1.72302097705118 0.0400452515456526 no 196 0.0424423658329229 288 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides. SGTC_758 0868-0029 16 µM 1.71870922303859 0.0404274944967836 no 197 0.0428336659011804 322 762687 SGTC_1754 st042065 16.137 µM 1.71309873879741 0.0409293014383742 no 198 0.0433471880149979 519 1126236 YIL048W NEO1 SGTC_461 N-acetylfarnesylcysteine 136 µM 1.70810498384545 0.0413801865172759 no 199 0.0438084321617771 205 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ). SGTC_532 1548-0774 215 µM 1.70755087034668 0.041430464482044 no 200 0.043859855540819 332 5932993 SGTC_698 k064-0052 127 µM 1.70014156896761 0.0421075222691136 no 201 0.0445521499298437 233 5088751 SGTC_2615 purpurogallin-4-carboxylic acid 100 µM 1.69547356745398 0.0425386604884808 no 202 0.0449928102036262 383 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase. SGTC_1027 k015-0025 8.67 µM 1.69240026564083 0.0428244554844647 no 203 0.045284840874995 343 3598955 SGTC_2641 levomentholum 100 µM 1.68708019940914 0.043322850239026 no 204 0.0457939659227493 238 16666 SGTC_257 daunorubicin 18.5 µM 1.68073952259622 0.043922964073952 no 205 0.0464067601059557 275 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_469 w7 172 µM 1.67825256688691 0.0441601651618655 no 206 0.0466489018051384 228 45115570 A P450 inhibitor. SGTC_3178 9107506 49.47 µM 1.67147475668777 0.0448118651943596 no 207 0.0473139703621412 332 8897194 SGTC_2850 9015429 58.44 µM 1.67059650809132 0.04489687439441 no 208 0.0474007013448289 324 6457570 SGTC_2168 5727979 200 µM 1.66991784245057 0.0449626540442902 no 209 0.0474678098347728 307 695210 SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM 1.66201507732127 0.0457343545348369 no 210 0.0482548757167739 322 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair. SGTC_809 3998-0021 90 µM 1.65312657279537 0.0466149944905463 no 211 0.0491525531463906 296 715485 SGTC_1082 camptothecin 424.86 nM 1.65191006406733 0.0467365732678326 no 212 0.0492764430768794 345 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_1060 3448-7350 82 µM 1.64995524229228 0.0469324723057419 no 213 0.049476045346266 374 570178 SGTC_3045 9092950 49.47 µM 1.64424061300758 0.0475089323374693 no 214 0.0500632554671617 372 44120432 SGTC_2388 9080168 200 µM 1.63880450032246 0.0480625481604039 no 215 0.0506269908183051 290 15943073 SGTC_479 n-linoleoylglycine 10 µM 1.6359508614459 0.0483552235583517 no 216 0.0509249359834156 288 6433346 An anti-infammatory. SGTC_1348 1493-0373 93.8 µM 1.63399772864952 0.0485563615676324 no 217 0.0511296637614519 320 3010129 SGTC_790 1575-0012 79.1 µM 1.62857109616759 0.0491187211887517 no 218 0.051701923593091 375 378741 YLR208W SEC13 SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM 1.61818233927835 0.0502098077293581 no 219 0.0528116538677569 374 2333 A French combination drug. SGTC_1887 st057648 70.8 µM 1.6166804507874 0.0503691308567417 no 220 0.0529736379461787 350 688672 SGTC_374 0880-0231 82.3 µM 1.61666831327627 0.0503704200656457 no 221 0.0529749486236908 363 6833587 SGTC_1818 st052136 56.3 µM 1.61548986189644 0.0504957167939775 no 222 0.053102327027883 388 674169 SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM 1.60943501090812 0.0511434081483765 no 223 0.0537606274544872 321 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding. SGTC_1797 st048695 56.8 µM 1.60349783396529 0.0517849141919013 no 224 0.0544123934810267 385 592262 YIL048W NEO1 SGTC_739 1486-1183 203 µM 1.59746037505585 0.0524437974921934 no 225 0.0550815618148138 371 4346692 SGTC_2688 kanamycin b 96.69 µM 1.58822511458585 0.0534645215176487 no 226 0.0561177219913534 925 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis. SGTC_1067 clotrimazole 1.36 µM 1.58754888181194 0.0535398761795926 no 227 0.0561941925867573 403 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_2478 5763493 32.33 µM 1.5863873958801 0.0536695004233852 no 228 0.0563257289125663 366 1365576 YLR208W SEC13 SGTC_3170 9103054 49.47 µM 1.58297794225717 0.0540514387180999 no 229 0.0567132460011875 340 16432970 SGTC_1427 4048-4900 550 nM 1.58164857061064 0.0542009410373188 no 230 0.0568649097088443 367 24132586 SGTC_2549 cedrol 20.94 µM 1.56983720297616 0.0555436694820839 no 231 0.0582264950200835 318 6708665 A sedative which affects the nervous system. SGTC_701 4424-0219 185 µM 1.56686182644385 0.0558860204037396 no 232 0.0585734960612946 412 2911779 SGTC_550 4123-0385 25.7 µM 1.56677601791115 0.055895918293178 no 233 0.0585835274510271 373 5731123 SGTC_660 4031-1742 102 µM 1.56575314624947 0.0560140115778317 no 234 0.0587032094796879 439 6738706 SGTC_275 trichlorophene 5.69 µM 1.56362995737678 0.0562597675671431 no 235 0.0589522476889164 586 62616 SGTC_651 3253-0966 34.4 µM 1.56338766654786 0.0562878663286071 no 236 0.0589807196660412 422 781462 SGTC_2359 9039622 200 µM 1.55971242536038 0.0567154465880084 no 237 0.0594139272587876 387 6463596 SGTC_376 3970-0862 59.1 µM 1.55936899208125 0.0567555322309134 no 238 0.0594545354872359 394 3135186 SGTC_3124 9127567 49.47 µM 1.55565285158017 0.0571907098843605 no 239 0.0598953318738199 352 17592030 SGTC_2228 7354201 200 µM 1.5550408249224 0.0572626323222561 no 240 0.0599681733437798 341 753451 SGTC_3253 9135987 49.47 µM 1.55379759906311 0.0574089493973361 no 241 0.0601163517202824 337 4182430 SGTC_1903 st060211 78.3 µM 1.55363236206101 0.0574284185079364 no 242 0.0601360676548025 414 688960 SGTC_3345 9148410 3.559 µM 1.54903390635985 0.0579723198151385 no 243 0.0606867847665274 329 4903596 SGTC_1308 1187-1617 41.4 µM 1.54745661105844 0.058159810662375 no 244 0.0608765896747227 444 2882570 SGTC_927 2425-1185 123 µM 1.54622258303287 0.0583068297294422 no 245 0.061025410653822 380 730375 SGTC_2778 tioconazole 65.09 nM 1.54473689531961 0.0584842180218165 no 246 0.0612049583398565 451 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_3257 9139206 32.98 µM 1.54313159583963 0.0586763637588978 no 247 0.0613994250025003 304 4910041 SGTC_2374 9071832 200 µM 1.54108429982902 0.0589221326771609 no 248 0.0616481352186898 359 17381698 SGTC_1641 st009299 47.1 µM 1.5401245279472 0.0590376268218176 no 249 0.0617650010075461 310 4046054 SGTC_3309 9129340 25.759 µM 1.53954975668164 0.0591068768926474 no 250 0.0618350702853729 416 17158987 SGTC_1300 1094-0077 113 µM 1.53573673206682 0.0595678954688119 no 251 0.0623014811526797 363 5532636 SGTC_3037 9091026 49.47 µM 1.52868608191841 0.0604277815115603 no 252 0.0631711421448793 552 25236398 YIL048W NEO1 SGTC_2818 7996756 12.99 µM 1.521829876593 0.0612732387608556 no 253 0.0640258566672579 298 2241621 SGTC_1688 st021091 57.6 µM 1.51748554809613 0.0618137149673463 no 254 0.0645720697683761 376 3656366 SGTC_339 3091-4833 71.4 µM 1.51562163957924 0.0620467408642706 no 255 0.0648075260295243 385 3240077 SGTC_1657 st012939 43.4 µM 1.51431743802551 0.0622101993700794 no 256 0.0649726739406021 361 24207257 SGTC_57 miconazole 162.5 nM 1.51392740573625 0.0622591481835409 no 257 0.065022126195147 385 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_597 k018-0003 82.8 µM 1.51388327990608 0.0622646878391925 no 258 0.0650277227550297 429 6786234 SGTC_3339 9145883 14.936 µM 1.51325375649551 0.062343761492489 no 259 0.0651076070839934 391 2030670 SGTC_950 1165-0508 94.1 µM 1.51260987124552 0.0624247201095003 no 260 0.065189392642311 412 6148369 SGTC_1152 3909-8331 15.9 µM 1.50795957848339 0.0630118587439099 no 261 0.0657824363498735 385 16001939 SGTC_2482 5981709 142.65 µM 1.50594831303321 0.0632671266654649 no 262 0.0660402213652566 454 877755 SGTC_1055 3448-0672 86 µM 1.50229769434971 0.0637325158964015 no 263 0.0665101219249564 413 748378 SGTC_1811 st050069 61.5 µM 1.49855193660403 0.064212797409899 no 264 0.0669949547280609 339 3877702 SGTC_1743 st037606 46.3785 µM 1.49855142442479 0.0642128632734093 no 265 0.0669950212084848 413 590142 YLR208W | YDL195W SEC13 | SEC31 SGTC_783 0848-0141 92.7 µM 1.4977627204651 0.0643143486975092 no 266 0.067097454854511 395 6755076 YHR007C | YLR033W ERG11 | RSC58 SGTC_2624 nerol 100 µM 1.49761087998383 0.0643339008684086 no 267 0.0671171891714467 374 637566 A natural product oil. SGTC_3308 9128332 17.569 µM 1.49546146885169 0.0646111716528427 no 268 0.0673970243092851 532 17332805 YDL196W YDL196W SGTC_2675 theaflavin digallate 100 µM 1.4946925533044 0.06471058570093 no 269 0.0674973493181688 425 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative. SGTC_2273 7815444 169.05 µM 1.49222970770639 0.065029809786626 no 270 0.0678194684369279 407 2824616 SGTC_849 0386-0493 241 µM 1.49092923623187 0.0651988640233122 no 271 0.0679900372895516 399 726119 SGTC_907 3448-6986 75.5 µM 1.49089310702048 0.0652035654885592 no 272 0.0679947806940376 475 590582 SGTC_484 loperamide 105 µM 1.48459934968867 0.0660265884939455 no 273 0.0688249939235844 297 3955 An opioid-receptor agonist. SGTC_3331 9141060 1.957 µM 1.47754506626374 0.0669586056505662 no 274 0.0697647936431764 416 4906567 YPR165W RHO1 SGTC_892 0929-0076 29 µM 1.47590149934798 0.0671772097559361 no 275 0.069985168475616 488 5751038 SGTC_2514 salinomycin 42.74 µM 1.47563162747886 0.0672131569935934 no 276 0.0700214049170918 501 23682228 A polyether potassium ionophore. SGTC_1906 st060206 94.7 µM 1.47499239006026 0.0672983634743739 no 277 0.0701072946808868 459 5133468 SGTC_524 r073-0010 27.8 µM 1.47384796562245 0.0674511168659298 no 278 0.0702612652101452 422 2772106 SGTC_626 0214-0009 33 µM 1.47327140814754 0.0675281749858816 no 279 0.0703389335290899 444 3437874 SGTC_254 nsc-64875 3.808 µM 1.46753659528787 0.0682983526873368 no 280 0.0711150708720482 420 56993 SGTC_448 monastrol 171 µM 1.46589810709826 0.0685196398464791 no 281 0.071338023866381 417 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM 1.45809969370256 0.0695804478425557 no 282 0.0724065329091929 714 16725076 SGTC_2079 5212404 121 µM 1.45391134729744 0.0701553790228249 no 283 0.0729854432014039 416 758462 SGTC_2272 7805186 180 µM 1.45155443309432 0.0704805137113333 no 284 0.0733127682796241 418 2956062 YPR165W RHO1 SGTC_1889 st059080 5.18 µM 1.4486063110191 0.0708888343068904 no 285 0.0737237788715965 476 176925 Isolated from Daphnopsis sellowiana. SGTC_3006 9075424 71.4286 µM 1.44748218174135 0.0710450060666058 no 286 0.0738809616771273 432 7465181 SGTC_3267 9137951 49.47 µM 1.44636163298232 0.0712009432309968 no 287 0.0740378985794793 372 16643986 SGTC_1878 temozolomide 1 mM 1.44317034590415 0.0716464872837761 no 288 0.074486245421255 413 5394 DNA alkylating agent. SGTC_1240 0356-0016 42.1 µM 1.44231456793623 0.071766327653128 no 289 0.074606826160106 460 4305613 SGTC_2653 dihydrofissinolide 100 µM 1.44075002541286 0.0719858185216835 no 290 0.0748276582499927 399 6857746 SGTC_3021 9087658 49.47 µM 1.43766817763488 0.0724196783196097 no 291 0.0752641131708301 386 25237042 SGTC_231 b-estradiol 524 µM 1.43683040547479 0.0725379647728833 no 292 0.075383094301305 379 450 A steroid. SGTC_714 4296-0578 26.1 µM 1.43553018991047 0.0727218373798932 no 293 0.075568035876662 332 1589775 SGTC_2978 9011784 42.97 µM 1.43166890422404 0.0732699928192806 no 294 0.0761192998517263 532 2994934 SGTC_2037 5169046 200 µM 1.43014851769227 0.0734866950497019 no 295 0.0763371988352076 426 5718022 SGTC_111 0083-0039 52.457 µM 1.43001695756479 0.0735054694635948 no 296 0.0763560760785311 290 759313 SGTC_2468 5987765 72.9 µM 1.42871212948944 0.0736918748419748 no 297 0.076543495051847 459 26772094 SGTC_1880 MG-132 525 µM 1.41901566880793 0.0750884318926389 no 298 0.0779472240008455 424 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1 SGTC_2875 9039966 71.43 µM 1.40930057545042 0.0765078234196372 no 299 0.0793731543738155 410 6463691 SGTC_596 1155-0152 116 µM 1.40359599775577 0.0773507305481037 no 300 0.080219593796914 547 280313 SGTC_1198 1612-1005 86.7 µM 1.39544990056395 0.0785665996253907 no 301 0.0814401062514098 485 6998509 SGTC_669 0108-0021 26.2 µM 1.39518584892826 0.0786062524310212 no 302 0.0814799016048397 604 17201 SGTC_942 3253-1115 227 µM 1.39350620943823 0.0788588401813115 no 303 0.0817333843142731 485 46497897 SGTC_781 4335-2806 94.4 µM 1.3846391943811 0.0802024817781095 no 304 0.0830814102396759 549 845254 SGTC_1344 1488-0097 29.1 µM 1.38312093485481 0.0804342724556995 no 305 0.083313893784447 494 747966 SGTC_2074 5212007 75.395 µM 1.37953627557457 0.0809835453655103 no 306 0.0838647348406664 413 758611 SGTC_3312 9133330 71.43 µM 1.37821238952862 0.0811871171054493 no 307 0.0840688615621867 511 17617324 SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM 1.37773043708349 0.0812613219150809 no 308 0.0841432651612502 435 364106 SGTC_2516 gossypol 71.55 µM 1.37724678570064 0.0813358397328478 no 309 0.0842179807236256 517 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_1367 1812-0510 76.9 µM 1.37674583739791 0.0814130768793071 no 310 0.0842954208413168 482 1142582 YDR527W RBA50 SGTC_2872 9044037 25.97 µM 1.37192841302569 0.0821586624967662 no 311 0.0850428621317811 414 6465195 SGTC_667 1498-1044 59 µM 1.37020776296981 0.0824262078702074 no 312 0.0853110278557027 496 6739982 SGTC_812 4251-0442 148 µM 1.36596820806374 0.0830882186272693 no 313 0.0859744711059857 467 5723007 SGTC_34 0469-0683 81.75 µM 1.36371069007812 0.0834423598657627 no 314 0.0863293191104839 478 3690923 SGTC_1756 st041558 35.5 µM 1.36266962996651 0.0836060546924603 no 315 0.0864933266846037 548 3955792 SGTC_2188 6126565 140.678 µM 1.36058512720287 0.0839345440384964 no 316 0.0868224171505617 436 874518 SGTC_915 methyl methanesulfonate (MMS) 110 mM 1.35607913130582 0.0846479383552245 no 317 0.0875369959700506 504 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks. SGTC_1555 citronellol 128 µM 1.35349737761575 0.0850587285514644 no 318 0.0879483936194135 470 8842 A terpine precursor. SGTC_1121 fusaric acid 630.51 nM 1.35058130977286 0.0855245072258846 no 319 0.0884147956204043 519 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler. SGTC_2436 5633522 8.09 µM 1.34799334377766 0.0859394762154786 no 320 0.0888302617388055 535 5724242 SGTC_2304 7443016 91.4 µM 1.34788872498623 0.0859562830099123 no 321 0.0888470875171724 451 939854 SGTC_557 1315-0110 16.2 µM 1.34743132514709 0.0860297922413839 no 322 0.0889206787303356 514 6833801 SGTC_905 2-aminofluorene 215 µM 1.34721560661911 0.0860644769216387 no 323 0.0889554014998668 548 1539 An established DNA mutagen. YPR165W RHO1 SGTC_1833 st055984 71 µM 1.34650271374805 0.0861791750657616 no 324 0.0890702228959444 488 676288 SGTC_2395 5646831 180.19 µM 1.34619408093543 0.0862288668009878 no 325 0.0891199667404866 507 6808628 SGTC_1104 tacrolimus 29.8 µM 1.34077518217389 0.0871048368106041 no 326 0.0899967281192809 556 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41 SGTC_2317 5986382 200 µM 1.33960663300911 0.0872946019208055 no 327 0.0901866331114552 518 877883 SGTC_2957 9076800 11.52 µM 1.33926979140893 0.0873493601659753 no 328 0.0902414296430073 466 16459615 SGTC_3337 9144342 33.5465 µM 1.33845478227227 0.0874819572059097 no 329 0.0903741155456594 513 17682949 SGTC_2832 7992762 51.95 µM 1.33400851201414 0.0882079846758514 no 330 0.0911005334579018 455 2985177 SGTC_1699 st031318 29.054 µM 1.33359483298061 0.0882757616528213 no 331 0.0911683386257084 508 5340658 SGTC_966 1300-0360 30.2 µM 1.33237381443612 0.0884760391024917 no 332 0.0913686911774411 523 70588 SGTC_658 3253-0951 102 µM 1.33125173917797 0.0886603857081012 no 333 0.0915530961044653 639 1184878 SGTC_2534 helenine 20.12 µM 1.33106951950083 0.0886903497003905 no 334 0.0915830685996454 457 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58 SGTC_792 4534-1957 155 µM 1.32829935572296 0.0891468014881501 no 335 0.0920396162532202 512 1717904 SGTC_2214 7179297 48.276 µM 1.32716554397163 0.0893341278813209 no 336 0.092226963765158 487 769744 SGTC_847 0342-0274 5.54 µM 1.32554997871331 0.089601554432987 no 337 0.0924944021688897 528 18097 SGTC_962 1254-0300 21.5 µM 1.32443794373172 0.0897859765775133 no 338 0.092678819988054 525 7340576 SGTC_818 4072-2707 53.5 µM 1.3223190772143 0.0901381544832063 no 339 0.0930309613986055 497 882871 SGTC_1449 4112-4002 201 µM 1.32130684306129 0.0903067602312832 no 340 0.0931995365996914 515 2059539 SGTC_3273 9137859 49.47 µM 1.31722246077338 0.0909894669794401 no 341 0.0938820336135358 474 2377234 SGTC_204 PMA1.184 62.41 µM 1.31590789803307 0.091210009233606 no 342 0.0941024787734839 593 2252213 YGL008C PMA1 SGTC_2059 5238311 157 µM 1.31567363531562 0.0912493527219887 no 343 0.0941418034415189 522 703021 SGTC_734 2023-0417 80 µM 1.31551849268357 0.0912754152330227 no 344 0.0941678532356758 541 3935732 SGTC_509 pifithrin 175 µM 1.31351630176961 0.0916122599473222 no 345 0.0945045157244572 516 4817 A p53 inhibitor. SGTC_2683 piperine 63.03 µM 1.31176899373726 0.091906975602191 no 346 0.094799044825637 507 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_2058 5236698 133 µM 1.31100934696253 0.0920353227796834 no 347 0.0949273028770584 539 766665 SGTC_721 1187-1332 279 µM 1.31007938298797 0.0921926267602831 no 348 0.095084491118111 437 25730 SGTC_802 4112-3352 742 µM 1.3051858975499 0.0930236428894264 no 349 0.0959147775261953 610 704594 SGTC_938 3126-1755 342 µM 1.30402246754257 0.0932220298275256 no 350 0.0961129610112471 575 1777771 SGTC_678 1218-2179 85.9 µM 1.30350713129593 0.0933100042963582 no 351 0.0962008416698773 481 6820081 YOR116C RPO31 SGTC_2876 9059903 25.97 µM 1.30331155249801 0.0933434081428279 no 352 0.0962342093198946 563 6916095 SGTC_640 3381-0960 37.1 µM 1.3026752755585 0.0934521420715807 no 353 0.0963428232281674 568 1745025 SGTC_1189 1431-2119 7.28 µM 1.30251952877891 0.0934787720237458 no 354 0.0963694232743541 568 3107275 SGTC_1287 0971-0001 34.6 µM 1.29955855937926 0.0939861122055291 no 355 0.0968761553514221 599 4665869 SGTC_1515 3460-0031 42.1 µM 1.29954098846571 0.0939891289041045 no 356 0.0968791682167297 468 2876596 SGTC_1692 fluoroquinolonic acid 71 µM 1.29595178367549 0.0946068479571697 no 357 0.0974960484802985 518 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2 SGTC_1070 indatraline 8.81 µM 1.29406987011497 0.0949319276270625 no 358 0.0978206438645974 570 10314472 A monamine transport inhibitor. YGL099W LSG1 SGTC_1328 1441-0025 69.2 µM 1.29340558399442 0.0950468719632665 no 359 0.0979354099236231 496 4562601 SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM 1.28929379203766 0.0957606351565687 no 360 0.0986479841901183 517 2374 Ca(2+)-ATPase inhibitor. SGTC_999 SEC7.066 22.7 µM 1.28875261545473 0.0958548705066309 no 361 0.0987420520740887 585 740511 YDR170C SEC7 SGTC_1520 flindersine 88 µM 1.28775033238681 0.0960295786746034 no 362 0.098916443319003 579 68230 Flindersine is a natural alkaloid of the quinoline subtype. SGTC_760 0568-0725 82.9 µM 1.28729991158127 0.0961081678288644 no 363 0.0989948871838676 565 3916171 SGTC_499 genistein 192 µM 1.285950648953 0.0963438693377543 no 364 0.0992301428188936 497 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger. SGTC_1423 4048-0112 5.59 µM 1.28357563624929 0.0967597897648455 no 365 0.099645239524565 555 X1423 SGTC_1290 0986-0249 10.2 µM 1.28172740438868 0.0970843697220324 no 366 0.099969144053105 504 53329 SGTC_1056 3448-1962 115 µM 1.2810449384393 0.0972044237845612 no 367 0.100088941078296 538 715507 SGTC_1828 st055811 49 µM 1.27894199913655 0.0975750413715182 no 368 0.100458740685742 496 5877589 SGTC_365 0121-0052 13.6 µM 1.27502382413399 0.0982683344070762 no 369 0.10115040480136 627 3101739 SGTC_2487 5918373 44.05 µM 1.2726759588179 0.0986854974067214 no 370 0.101566526039232 585 2876279 SGTC_1722 st034304 3.6505 µM 1.27251262648596 0.0987145660459469 no 371 0.101595520370057 583 4036148 YLR033W RSC58 SGTC_3175 9106517 49.47 µM 1.27123162333566 0.0989427665239983 no 372 0.101823129751208 533 41468073 SGTC_890 0929-0006 47.2 µM 1.26991209475426 0.0991782332751225 no 373 0.102057972210502 541 1378169 SGTC_300 r073-0011 5.04 µM 1.26876841381159 0.0993826517226472 no 374 0.102261836881512 632 2735780 SGTC_2586 curcumin 80 µM 1.26534058501217 0.0999971772957565 no 375 0.102874631935735 660 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40 SGTC_1741 st038134 10.228 µM 1.26478806449042 0.10009648978339 no 376 0.102973655532974 608 1272587 SGTC_258 haloperidol 50.781 µM 1.26467245836085 0.100117278448514 no 377 0.10299438340209 559 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_887 0885-0007 9.62 µM 1.2643845788942 0.100169059555402 no 378 0.10304601258927 604 5719458 SGTC_2371 9071574 200 µM 1.26050073816608 0.100869561099058 no 379 0.103744390885995 504 45596039 SGTC_1962 st076595 64.5 µM 1.25996261590095 0.100966899535194 no 380 0.103841424293544 578 279619 SGTC_486 niguldipine 82 µM 1.25555530156114 0.101766696199656 no 381 0.104638622970208 516 1236 A calcium channel blocker. SGTC_3275 9138069 49.47 µM 1.25512982677398 0.101844150667651 no 382 0.104715817198107 546 17617007 SGTC_2403 6032726 181.2 µM 1.25476522783699 0.101910557279251 no 383 0.104781999479106 570 2881040 SGTC_147 4466-0538 29.23 µM 1.25461651037024 0.1019376531385 no 384 0.104809003484108 606 6742687 YHR072W ERG7 SGTC_1264 0783-0040 158 µM 1.25299876994724 0.102232739178087 no 385 0.105103077174607 535 2855798 SGTC_1881 5652484 16 µM 1.25253701898378 0.102317079334381 no 386 0.105187123948739 572 2255129 SGTC_3207 9114163 49.47 µM 1.25196410619914 0.10242179384932 no 387 0.105291471715891 651 849233 SGTC_2900 5328528 85.29 µM 1.2460970952896 0.103498628442787 no 388 0.106364375552629 627 795359 SGTC_223 busulfan 5 mM 1.24587679713367 0.103539221549374 no 389 0.106404814833683 476 2478 A DNA alkylator. SGTC_2047 4141938 200 µM 1.24060349584058 0.104514354121654 no 390 0.107376129951521 530 3807862 SGTC_768 0384-0033 77.3 µM 1.23648047127628 0.105281400857283 no 391 0.108140010183964 643 3965305 YMR134W ERG29 SGTC_868 0527-0199 213 µM 1.23564028967359 0.105438206380446 no 392 0.108296150788491 611 2849450 SGTC_1166 k206-0078 225 µM 1.23500019737519 0.105557781978718 no 393 0.108415215341221 626 5404595 SGTC_719 2810-4230 27.3 µM 1.23345704848202 0.105846460639615 no 394 0.108702646020466 552 721079 SGTC_3141 9094609 49.47 µM 1.22887502589358 0.106706986587234 no 395 0.109559333175438 560 25236309 YDL196W YDL196W SGTC_1007 4101-0031 70 µM 1.22624934753841 0.107202371464552 no 396 0.110052428106745 619 1146276 SGTC_3250 9135583 49.47 µM 1.22576422344229 0.107294080693209 no 397 0.110143707027241 567 7699353 SGTC_1065 prochlorperazine maleate 2.48 µM 1.22552788407756 0.107338779438201 no 398 0.110188195321388 620 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine. SGTC_709 3807-1509 243 µM 1.22501336915957 0.1074361358053 no 399 0.110285091682782 569 1886677 YPL242C IQG1 SGTC_1199 1638-0010 4.46 µM 1.22463924420367 0.107506967577962 no 400 0.110355587373067 633 3111136 SGTC_1448 4255-0083 152 µM 1.22385282350161 0.107655967576132 no 401 0.110503876539909 617 5399660 SGTC_1434 4073-0095 163 µM 1.22363420347892 0.107697415058618 no 402 0.11054512536134 630 24133745 SGTC_1036 k216-0215 33.5 µM 1.22355143203757 0.1077131104357 no 403 0.110560745403849 638 622330 SGTC_1453 4237-0541 195 µM 1.22342149373094 0.10773775306371 no 404 0.110585269635557 617 739892 SGTC_1353 1498-1206 8.11 µM 1.22302090311286 0.107813750104898 no 405 0.110660900648508 682 6756808 SGTC_831 k061-1017 217 µM 1.22010402640309 0.108368282423593 no 406 0.111212721206046 780 1240153 SGTC_2938 9059746 27.26 µM 1.21965515027299 0.108453800912546 no 407 0.111297815104633 580 6471769 SGTC_2153 5569715 200 µM 1.21921821894639 0.108537090338249 no 408 0.111380689370668 592 2054701 SGTC_221 trifluoperazine 10.304 µM 1.21701943991201 0.108956927966707 no 409 0.111798409776798 757 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1 SGTC_3263 9137018 49.47 µM 1.21613898857511 0.109125369350379 no 410 0.111965990245968 576 43844957 SGTC_2963 9082507 9 µM 1.21015942275642 0.110274287785937 no 411 0.113108862519333 576 16459611 SGTC_2710 st078562 53.7235 µM 1.20594755107634 0.11108875068401 no 412 0.113918857134909 603 17250908 SGTC_856 0433-0016 11.3 µM 1.20509646270643 0.111253850181496 no 413 0.114083032604361 635 3911780 SGTC_520 3584-0023 682 µM 1.20436020534669 0.11139681568544 no 414 0.114225193008794 589 1340790 SGTC_1122 capsaicin 818.572 nM 1.20365633102404 0.111533615992992 no 415 0.114361218641316 628 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_1710 st031758 61.5 µM 1.2036194759813 0.111540782203236 no 416 0.114368344155001 585 5394341 SGTC_2449 5812982 45.77 µM 1.20143564307705 0.111966001860556 no 417 0.114791128452763 576 776185 SGTC_3201 9113999 49.47 µM 1.2009166503217 0.112067226496425 no 418 0.114891767399604 619 16649224 SGTC_2234 tolnaftate 200 µM 1.1990681133602 0.112428297625534 no 419 0.115250730803678 548 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7 SGTC_737 1950-0117 57.9 µM 1.19538995176096 0.113149216282734 no 420 0.115967354859571 615 5393513 SGTC_79 0052-0007 94.094 µM 1.19493074186753 0.113239452378341 no 421 0.116057045348637 632 2801472 SGTC_1216 1165-0504 9.65 µM 1.19312048280442 0.113595673688525 no 422 0.11641109536286 651 6304004 SGTC_262 fenpropimorph 62.5 µM 1.18977445366616 0.114256204209579 no 423 0.117067526449656 575 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_1720 st037298 9.481 µM 1.18894836587622 0.114419700105887 no 424 0.117229993018131 594 597396 SGTC_1686 st019653 115.5 µM 1.18694334620091 0.114817217880582 no 425 0.117624984030069 624 97252 SGTC_929 2805-0021 398 µM 1.18607861678004 0.114988963139929 no 426 0.117795627084637 602 3098024 SGTC_3254 9136651 49.47 µM 1.1858665983112 0.115031100334328 no 427 0.117837492887909 659 16454030 SGTC_3276 9139060 49.47 µM 1.18126942843699 0.115947457338428 no 428 0.118747853999771 587 4870619 SGTC_1093 fluphenazine 7.97 µM 1.17893057902121 0.116415645774703 no 429 0.119212910047771 661 6602611 An atypical antipsychotic. SGTC_1857 st056007 79.3 µM 1.17760441654217 0.116681710624528 no 430 0.119477174164063 603 619834 SGTC_2170 morpholine 200 µM 1.17618458302828 0.116967046078967 no 431 0.119760561904459 655 121171 Reacts with secondary amines. SGTC_2301 7769476 200 µM 1.17554124443597 0.117096496651633 no 432 0.11988912320598 588 977820 SGTC_1788 fluconazole 20 µM 1.17410271617436 0.117386319959572 no 433 0.12017694283225 611 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11 SGTC_2911 7942208 15.64 µM 1.17194220859896 0.117822555740474 no 434 0.120610129679564 598 1243384 SGTC_1123 mangostin 811.285 nM 1.16932580390736 0.118352377517711 no 435 0.121136195313017 625 5281650 An antioxidant. SGTC_215 1287-0124 461.5 µM 1.16891723879456 0.118435263725539 no 436 0.121218488654581 589 5560863 SGTC_3080 9117754 49.47 µM 1.16747176579233 0.118728838305415 no 437 0.121509951980161 713 9550191 SGTC_549 1661-1316 519 µM 1.16548716123677 0.119132747049777 no 438 0.121910927073305 668 2857282 SGTC_583 1488-1091 88.9 µM 1.16333027140929 0.119572818382239 no 439 0.122347764137517 770 4303273 SGTC_218 alverine citrate 93.75 µM 1.16251234651956 0.119739999513378 no 440 0.122513706249034 621 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_1023 4482-3888 16 µM 1.1623128373285 0.119780803523968 no 441 0.122554206989466 643 3303168 SGTC_1100 amiodarone 5.07 µM 1.16029018301747 0.120195034376026 no 442 0.122965340033675 686 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. SGTC_1902 st060212 70.5 µM 1.15933578127168 0.120390841824834 no 443 0.123159671074941 665 688944 SGTC_1268 0828-0275 2.46 µM 1.15575318979232 0.121127859500314 no 444 0.123891062458591 678 745337 SGTC_703 3875-0075 71.8 µM 1.15101198416809 0.122108100667855 no 445 0.124863652650613 707 2850814 SGTC_2464 5717415 7.67 µM 1.14984050817328 0.122351158372352 no 446 0.125104783801038 659 5285744 SGTC_922 1866-0035 480 µM 1.14841257396324 0.122647884957226 no 447 0.125399142668552 767 3156169 SGTC_1896 st058441 89 µM 1.14644894538934 0.123056753389771 no 448 0.125804720257794 600 688759 SGTC_1177 0983-0204 23.6 µM 1.14353718451048 0.123664800022175 no 449 0.126407812590624 725 766818 SGTC_1375 2910-0797 186 µM 1.14280459577142 0.123818113078859 no 450 0.126559865129352 662 742508 SGTC_2146 5545642 200 µM 1.14208563024422 0.123968704443323 no 451 0.126709213922858 669 825326 SGTC_1 0258-0098 57.368 µM 1.14068675068077 0.124262074821834 no 452 0.12700015104158 584 6790032 YDR047W HEM12 SGTC_398 bronopol 33.3 µM 1.13991069458959 0.12442503710325 no 453 0.127161754522457 673 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them. SGTC_1170 0310-0127 64.8 µM 1.13914404364884 0.124586171095283 no 454 0.127321539938059 696 774975 SGTC_681 1642-0006 26.6 µM 1.13896006410047 0.124624861441924 no 455 0.12735990573192 652 4446530 SGTC_2849 9019321 12.99 µM 1.13888708392526 0.124640211279964 no 456 0.127375126728749 629 16489627 SGTC_1094 duloxetine 25.4 µM 1.13702668616182 0.125031952927406 no 457 0.127763564961603 653 60834 A selective serotonin reuptake inhibitor. SGTC_3321 9137793 26.8275 µM 1.13592597223701 0.125264133414369 no 458 0.127993773716881 693 4904192 SGTC_1760 st045453 10.4495 µM 1.13537899532291 0.125379622576286 no 459 0.128108278292669 700 3323419 YIL048W NEO1 SGTC_1294 1000-1494 117 µM 1.13119629963066 0.126265217889387 no 460 0.128986239533848 653 712797 YDL207W GLE1 SGTC_2704 st078022 71.1 µM 1.12430084610986 0.127734680366789 no 461 0.130442709778543 684 54697681 SGTC_998 3996-0085 177 µM 1.12257827642286 0.128103618510049 no 462 0.130808322901873 756 715391 SGTC_1197 1601-0112 267 µM 1.12254786245277 0.128110139184625 no 463 0.130814784583449 706 7350313 SGTC_2989 9073649 71.4286 µM 1.11975276298538 0.128710385491612 no 464 0.131409566916117 777 21367202 SGTC_2635 hydroquinidine 100 µM 1.11661408705102 0.129386737269108 no 465 0.13207968289256 702 442912 An experimental heart treatment. SGTC_990 3985-0011 41.3 µM 1.11645812060382 0.129420410518921 no 466 0.132113043504923 630 5399565 YGL099W LSG1 SGTC_508 roscovitine 141 µM 1.11530769671218 0.129668975319429 no 467 0.132359294150643 698 160355 A CDKinase inhibitor. SGTC_2180 6301957 200 µM 1.11471781775101 0.129796554883463 no 468 0.132485681590837 701 845462 SGTC_2668 2',4'-dihydroxychalcone 15.08 µM 1.11440826433615 0.12986354014418 no 469 0.132552039751218 672 5357218 A potent inhibitor of glutathione S-transferases. SGTC_611 3453-1652 23.7 µM 1.11433776148605 0.12987879982892 no 470 0.132567156464881 724 1560575 SGTC_688 0527-0193 473 µM 1.11293558335777 0.13018254610212 no 471 0.132868048128942 662 4007154 SGTC_940 3232-1287 54.8 µM 1.11212623082105 0.130358095347927 no 472 0.133041939978953 712 1585493 YIL048W NEO1 SGTC_1715 st032160 10.2275 µM 1.11197040233404 0.130391913468244 no 473 0.133075438178684 672 5289825 SGTC_1810 st050138 53 µM 1.11195219126093 0.130395866057287 no 474 0.133079353362678 656 3444541 SGTC_2813 7971799 71.43 µM 1.10747404958824 0.131370332843053 no 475 0.134044512975481 674 2234054 SGTC_2356 9061756 188.97 µM 1.10744168121994 0.131377394622233 no 476 0.134051506688909 671 20104043 SGTC_419 nsc-638432 893 µM 1.10688956238073 0.131497890281936 no 477 0.134170839571929 694 368090 SGTC_3251 9135047 49.47 µM 1.10533396383099 0.131837797805058 no 478 0.134507453124165 667 17682963 SGTC_2552 juarezic acid 87.02 µM 1.10334054562001 0.13227425688026 no 479 0.134939652610329 820 1549512 SGTC_587 k089-0003 57 µM 1.10307372066379 0.132332753720582 no 480 0.134997576003312 552 9659696 SGTC_132 0417-1715 25.805 µM 1.10085924567539 0.132818927823728 no 481 0.135478960863067 744 6769098 SGTC_2623 humulene 100 µM 1.10014451008004 0.132976105772592 no 482 0.135634581613013 602 6187145 An anti-inflammatory. SGTC_1618 st003135 44.5 µM 1.09756602689342 0.133544205618564 no 483 0.136197017228741 687 1270615 SGTC_1630 st005209 31.3 µM 1.0973077720286 0.133601196994951 no 484 0.136253437275744 798 3367314 SGTC_1072 oxiconazole 14.9 nM 1.09659158452259 0.133759331892971 no 485 0.136409983947151 746 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_1432 4049-0298 68.4 µM 1.09594359054207 0.133902520428424 no 486 0.136551730633496 691 741646 SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM 1.095446231471 0.134012494297132 no 487 0.136660594703749 800 551469 SGTC_2868 9035608 32.47 µM 1.0942339924876 0.134280799215392 no 488 0.136926183271023 700 6462614 SGTC_483 fpl-64176 144 µM 1.09231831584056 0.134705547730666 no 489 0.137346606251856 660 3423 SGTC_582 0987-0078 156 µM 1.09215683733592 0.134741393227178 no 490 0.137382085289769 839 1625765 SGTC_2040 5100729 123 µM 1.09163822977133 0.134856559597436 no 491 0.13749607279243 728 11840 YJR013W | YDR381W GPI14 | YRA1 SGTC_2316 5844804 197.44 µM 1.0915650467193 0.134872816678825 no 492 0.137512163279998 854 776813 SGTC_3220 9131269 49.47 µM 1.09026612722789 0.135161585884742 no 493 0.137797965807368 712 17722206 SGTC_1057 3448-5381 134 µM 1.08974547963801 0.135277452550233 no 494 0.137912638113064 723 5497911 SGTC_2991 9074669 71.4286 µM 1.08923039845625 0.135392147431574 no 495 0.13802614846133 760 17333109 SGTC_1220 1838-0075 193 µM 1.0842037040804 0.136514957613394 no 496 0.139137244853897 736 5529645 SGTC_1499 4480-0877 67.3 µM 1.08310790455021 0.136760568863311 no 497 0.139380265417776 680 2861909 SGTC_2824 7998404 51.95 µM 1.07911245091051 0.137658663056446 no 498 0.140268800715827 676 837851 SGTC_821 1114-0266 29.2 µM 1.07738467885544 0.138048273873362 no 499 0.140654222983069 698 3123235 SGTC_3055 9094636 49.47 µM 1.07360360945256 0.138903522764878 no 500 0.14150018959455 692 25236176 SGTC_1141 3253-0389 52.6 µM 1.07154407221077 0.139370888942282 no 501 0.14196243261358 716 5402031 SGTC_2339 9000433 200 µM 1.07150977784482 0.139378680330673 no 502 0.141970138292461 643 2988954 SGTC_2980 9014342 25.29 µM 1.07048505494405 0.13961162537567 no 503 0.142200516250171 690 2996599 SGTC_2656 pseudo-anisatin 100 µM 1.06839784014169 0.140086919716294 no 504 0.142670545447046 725 6708809 A neurotoxin. SGTC_157 1348-1695 65.819 µM 1.06802832375559 0.140171179293357 no 505 0.142753867808622 770 5380510 SGTC_1325 1431-0015 227 µM 1.06766325142083 0.140254459310512 no 506 0.142836220378748 691 1103340 SGTC_2592 piperlongumine 83.33 µM 1.06761386488049 0.140265727909752 no 507 0.142847363399338 670 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_209 4077-0173 175.592 µM 1.06472214585514 0.140926607884655 no 508 0.143500842681272 621 15993494 SGTC_1804 st050076 49.1 µM 1.06301057411053 0.141318767869772 no 509 0.143888578040538 746 3895976 SGTC_543 3844-1095 191 µM 1.06173603916744 0.141611272856295 no 510 0.144177766792157 798 4230703 SGTC_3302 9125395 16.351 µM 1.06044804995528 0.141907281992054 no 511 0.144470406106889 727 17599668 SGTC_2750 bromebric acid 70.15 µM 1.06035588250747 0.141928480212872 no 512 0.144491362469596 793 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2 SGTC_2896 9052656 71.43 µM 1.05991306257595 0.142030357288242 no 513 0.144592076199007 814 6469436 SGTC_2691 st077356 60.2 µM 1.05820306081553 0.142424232312216 no 514 0.144981438070292 770 2839272 SGTC_2076 5212012 200 µM 1.05613294400194 0.142902042582008 no 515 0.145453740589825 655 604802 SGTC_1979 st071809 45.3 µM 1.05503318422918 0.143156321787823 no 516 0.145705074083289 768 4976333 SGTC_2587 piperic acid 92.2 µM 1.05374657568064 0.143454190659733 no 517 0.145999479406506 680 5370536 SGTC_197 4544-0043 41.561 µM 1.05278692307876 0.143676636658457 no 518 0.146219329823918 765 896523 SGTC_1870 st057514 26.5 µM 1.05187810714126 0.143887513293775 no 519 0.146427738761158 727 5393161 SGTC_2568 diosmetin 100 µM 1.05027015892435 0.14426112398089 no 520 0.146796960472489 791 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.  SGTC_1193 1488-0126 41.5 µM 1.04991005947858 0.144344883508046 no 521 0.146879733071779 763 1384710 SGTC_3048 9093155 49.47 µM 1.04869484367185 0.144627785950302 no 522 0.147159294099352 675 25236002 SGTC_2728 chlorpromazine 9.18 µM 1.04644651572368 0.145152181257827 no 523 0.147677463080565 641 2726 A thorazine and dopamine antagonist. SGTC_1151 3909-8316 15.3 µM 1.04467728237354 0.145565732074215 no 524 0.148086073929212 756 800431 SGTC_441 propafenone 146 µM 1.04183341107552 0.146232133791578 no 525 0.148744460447964 705 4932 Slows the influx of sodium ions into the cardiac muscle. SGTC_1425 4048-4433 7.33 µM 1.04128064847309 0.146361899584736 no 526 0.14887265763006 813 23734946 SGTC_1312 1218-2183 165 µM 1.03983303008047 0.146702106785194 no 527 0.149208740310808 792 6744073 SGTC_2333 9017922 200 µM 1.03961666487886 0.146753000673236 no 528 0.149259015681851 757 3163164 SGTC_3014 9081533 49.47 µM 1.03902034320984 0.146893330047403 no 529 0.149397637601705 802 21367265 SGTC_10 0279-0212 42.575 µM 1.0386597805243 0.14697822309685 no 530 0.149481496277986 858 39851 YBR002C RER2 SGTC_2644 guaiazulene 100 µM 1.03833959836358 0.147053636288677 no 531 0.149555989694364 768 3515 A coloring agent. SGTC_3341 9147222 25.867 µM 1.03211187174427 0.14852562649144 no 532 0.151009856513868 723 1939759 SGTC_3333 9141820 12.094 µM 1.03045384064044 0.14891917497015 no 533 0.151398505040509 710 1939433 SGTC_3325 9138760 55.175 µM 1.03027227420235 0.148962313672631 no 534 0.151441105246498 742 43844959 SGTC_1356 1502-0781 85.8 µM 1.02927153454674 0.149200231051186 no 535 0.151676047802795 754 567702 SGTC_2703 st077852 53.4 µM 1.02849345964756 0.149385387023848 no 536 0.151858882904465 738 6281836 SGTC_601 0986-0029 62.9 µM 1.02550257013651 0.150098546904365 no 537 0.152563056664102 812 24747981 SGTC_1380 2291-0730 164 µM 1.02516037039292 0.150180286863708 no 538 0.152643761925266 731 2999191 SGTC_1809 st050081 57.6 µM 1.01968913879875 0.151491208521182 no 539 0.15393795718298 786 5036894 SGTC_460 trequinsin 123 µM 1.01818628017105 0.151852625398687 no 540 0.154294719138365 850 5537 A vasodilator. SGTC_2152 5568786 200 µM 1.01087406905939 0.153619280861056 no 541 0.156038353241249 772 5399883 SGTC_1582 3',3',6'-trihydroxyflavone 74 µM 1.01029727337087 0.153759213470315 no 542 0.156176443549504 747 688803 SGTC_3051 9093778 49.47 µM 1.00157031720192 0.15588669694252 no 543 0.158275581477596 742 17217378 SGTC_2442 5158906 48.48 µM 0.999771948919412 0.156327508640537 no 544 0.158710441908776 815 1893835 SGTC_1768 st044301 37.178 µM 0.992381711934555 0.158147597256214 no 545 0.160505678332552 819 3931349 SGTC_2578 7,8-dihydroxyflavone 64.44 µM 0.992196807101988 0.158193313780439 no 546 0.160550764872534 761 1880 Intensifies effect of antibiotics on Staphylococcus aureus. SGTC_2279 7948423 32.93 µM 0.990877291237071 0.158519807304049 no 547 0.160872751103912 764 1247112 SGTC_2270 7924575 90.91 µM 0.990158461629194 0.158697856251305 no 548 0.161048336055318 843 1262135 SGTC_2804 7954240 19.48 µM 0.990127331092535 0.158705570023262 no 549 0.16105594298181 853 828705 SGTC_5 0352-0601 109.883 µM 0.988681525925182 0.159064093940749 no 550 0.161409492147411 775 762456 SGTC_3242 9133940 49.47 µM 0.988105421053798 0.159207101426244 no 551 0.161550510543383 852 17248444 SGTC_627 1391-0720 175 µM 0.984916592322682 0.160000192365255 no 552 0.162332521249948 788 997839 SGTC_2572 astragaloside iv 100 µM 0.984462843114402 0.160113253565034 no 553 0.162443996120266 800 45006101 An anti-inflammatory agent. SGTC_993 3909-8757 62.7 µM 0.980996868315421 0.160978597296874 no 554 0.16329714294856 748 4288324 YLR208W SEC13 SGTC_2106 5357045 167.29 µM 0.980131534052429 0.161195119058555 no 555 0.163510597567574 838 668842 SGTC_364 0083-0097 67.7 µM 0.97990105232572 0.161252821644172 no 556 0.16356748173682 808 5207356 SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM 0.97958464752519 0.161332057567805 no 557 0.163645593123999 740 6857784 SGTC_2095 5432005 200 µM 0.970300939996686 0.16366823822496 no 558 0.165948254441751 791 783734 SGTC_1908 st060353 56.5 µM 0.969226835582039 0.163939939665693 no 559 0.166216012272552 892 4227716 SGTC_3156 9099931 49.47 µM 0.968811853776877 0.164044990246974 no 560 0.166319535592151 880 18111053 SGTC_3174 9107204 49.47 µM 0.963963442092506 0.165275576182046 no 561 0.167532127356098 817 3938802 SGTC_2120 5538279 151.968 µM 0.963064366401338 0.165504427459323 no 562 0.167757611348281 843 2058197 SGTC_1478 0453-0656 35.7 µM 0.958894885420385 0.166568407618294 no 563 0.168805850809917 861 5258496 SGTC_2459 5811157 9.22 µM 0.958133811327431 0.166763096141556 no 564 0.168997643932113 862 2870684 YBR192W RIM2 SGTC_3087 9117406 49.47 µM 0.957117839100497 0.167023218258707 no 565 0.169253890245801 807 42546093 SGTC_2526 patulin 37.61 µM 0.957073251442198 0.167034640147812 no 566 0.169265141759002 881 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.  SGTC_497 capsazepine 133 µM 0.953384764646798 0.167981253032398 no 567 0.170197578917268 840 2733484 A calcium channel blocker. SGTC_1361 1608-0041 5.61 µM 0.952246831919443 0.168273987545211 no 568 0.170485907570692 859 X1361 SGTC_1042 0350-0096 82 µM 0.950492751229386 0.168725869188982 no 569 0.170930967697649 814 3122515 SGTC_285 1486-1325 46 µM 0.950299910966525 0.168775595726355 no 570 0.170979942065992 886 22310230 SGTC_1257 0669-0121 16 µM 0.946754034979426 0.169691627327837 no 571 0.171882064474223 941 4307855 SGTC_2253 7938677 135.83 µM 0.946034214297728 0.169877972436893 no 572 0.172065567778219 853 2301972 SGTC_1285 0929-0069 65.5 µM 0.945722817748396 0.1699586265214 no 573 0.1721449905846 852 1206237 SGTC_615 k087-0205 167 µM 0.945648057571993 0.169977993631628 no 574 0.172164061917941 803 9642773 SGTC_980 1473-0395 201 µM 0.944144303572875 0.170367851279522 no 575 0.172547956115481 788 768876 SGTC_1973 st070275 50.2 µM 0.94095130679942 0.171197553216477 no 576 0.17336490654486 854 17118334 SGTC_843 0310-0051 143 µM 0.939429248464708 0.171593968748053 no 577 0.173755200990027 857 2065037 SGTC_880 0833-0487 87.2 µM 0.938955545916173 0.171717462729432 no 578 0.17387678432062 844 76075 SGTC_2681 menadione 3.18 µM 0.936354301105099 0.172396617242565 no 579 0.174545399340141 866 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_3015 9080845 49.47 µM 0.932701315384795 0.173353257338662 no 580 0.175487102776806 940 5296973 SGTC_99 0109-0120 622.8 µM 0.931508452519483 0.17366637359324 no 581 0.175795307167095 839 759414 SGTC_129 0088-0017 176.636 µM 0.930810181541718 0.173849830584535 no 582 0.175975881024244 844 182446 SGTC_677 0929-0063 136 µM 0.930401269708528 0.173957321342734 no 583 0.176081680707288 808 1539583 SGTC_1062 mesoridazine 14.2 µM 0.929156551400981 0.174284780793216 no 584 0.176403980314814 877 4078 A neuroleptic. SGTC_1469 k284-2957 126 µM 0.928399965498707 0.174484014046278 no 585 0.176600068212417 879 23884841 SGTC_1984 st072354 53.1 µM 0.928301222784221 0.174510026827009 no 586 0.176625669987227 870 5762938 SGTC_2736 butenafine 14.65 µM 0.926651985644618 0.174944865941665 no 587 0.177053627167985 903 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_1643 st009866 20.2 µM 0.924397357540641 0.17554043429573 no 588 0.177639735005238 891 3156273 YOR207C RET1 SGTC_3258 9138477 49.47 µM 0.924271427140545 0.175573737123463 no 589 0.177672507638207 889 4970355 SGTC_301 4119-0100 24.5 µM 0.922979893894455 0.175915519640024 no 590 0.178008841610221 880 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1 SGTC_1143 3454-2408 5.08 µM 0.92131918907678 0.176355615952935 no 591 0.178441902759926 871 X1143 SGTC_3145 9085516 49.47 µM 0.917533325884986 0.177361492912206 no 592 0.179431618973212 842 25236195 SGTC_3132 9126706 49.47 µM 0.914212415912961 0.178246811316075 no 593 0.180302620689405 846 850858 SGTC_3143 9086658 49.47 µM 0.912394159870251 0.178732716365143 no 594 0.180780631380478 943 25236626 SGTC_953 1188-0045 9.7 µM 0.91162678851629 0.178938036290336 no 595 0.180982607760216 903 6144426 SGTC_1953 st076800 12.1 µM 0.911514436492814 0.178968109949382 no 596 0.181012191296053 867 297591 SGTC_711 k292-0785 179 µM 0.90712272761057 0.180146145297097 no 597 0.18217095029528 944 4146315 SGTC_752 1896-0090 130 µM 0.90265375061679 0.181349891641456 no 598 0.183354844851637 925 772567 SGTC_174 3553-0389 74.3 µM 0.901727021531261 0.181600140854075 no 599 0.183600947566285 850 738071 SGTC_2563 tomatine 8.54 µM 0.900568305851309 0.181913338412053 no 600 0.183908946215923 925 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties. SGTC_3000 9075062 71.4286 µM 0.899942078919785 0.182082746307965 no 601 0.184075537693566 858 17057871 SGTC_2271 7849410 118.62 µM 0.899804207719 0.182120056685625 no 602 0.184112227374839 906 972430 SGTC_1459 k035-0031 35.7 µM 0.895545463806578 0.183274900891717 no 603 0.185247786925054 806 3877128 YMR208W ERG12 SGTC_970 1315-0089 19.5 µM 0.89545623199634 0.183299146636269 no 604 0.185271626289328 872 6811083 YLR033W RSC58 SGTC_2889 9059656 51.95 µM 0.894319592005343 0.183608165324213 no 605 0.185575460162301 957 3949838 SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM 0.893806060119238 0.183747885814174 no 606 0.185712833102579 958 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis. SGTC_3226 9131256 49.47 µM 0.893059050201944 0.183951248649732 no 607 0.185912775449181 836 17178073 SGTC_296 1222-0039 74.9 µM 0.892950251967894 0.183980879111462 no 608 0.185941907177965 875 5984176 SGTC_1011 4112-3381 17.4 µM 0.892938347284849 0.183984121451584 no 609 0.185945094938238 905 2877139 SGTC_985 1493-0307 8.71 µM 0.892876493080712 0.184000968534749 no 610 0.185961658408865 893 3278274 SGTC_560 2332-1943 155 µM 0.892768143009476 0.184030481902009 no 611 0.185990674861644 909 21177716 SGTC_387 norethindrone acetate 66.7 µM 0.890337930125812 0.184693219383886 no 612 0.186642230078731 868 541197 SGTC_2725 haloperidol 53.21 µM 0.889917413250321 0.184808047937228 no 613 0.186755116528014 940 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_280 3448-3607 3.04 µM 0.88930955694201 0.184974110795589 no 614 0.186918368346306 946 626179 SGTC_98 0074-0023 107.663 µM 0.88911892300448 0.185026209986919 no 615 0.186969585039397 958 3563821 SGTC_76 0433-0009 400.328 µM 0.888956374644406 0.185070640746865 no 616 0.187013262974368 818 2841569 SGTC_1107 amlodipine 47 µM 0.886726642889931 0.185680781633531 no 617 0.187613045251751 880 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.  SGTC_1814 st052110 31.539 µM 0.884958048302715 0.186165623984941 no 618 0.188089629064351 923 674163 SGTC_2795 7780010 54.55 µM 0.883827867711687 0.186475862102094 no 619 0.188394570186891 874 953673 SGTC_639 0833-0042 114 µM 0.883455272250901 0.186578210868706 no 620 0.18849516930879 953 5978911 YPR085C | YHR062C ASA1 | RPP1 SGTC_1588 farnesol 29.9 µM 0.882183864439129 0.186927717441665 no 621 0.188838693088008 916 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_1159 4092-0538 61.2 µM 0.881360210706347 0.187154353709979 no 622 0.189061443231774 980 717301 SGTC_867 0518-0118 155 µM 0.879352487104564 0.187707509821307 no 623 0.189605092657604 977 6848158 SGTC_2009 4012297 12.05 µM 0.879251462075595 0.18773537030016 no 624 0.189632473505392 860 45595307 SGTC_1092 toremifene 6.32 µM 0.878238455534229 0.188014876399943 no 625 0.189907163471962 1017 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_83 0170-0301 39.027 µM 0.878231701924399 0.188016740699811 no 626 0.189908995622055 885 3089716 SGTC_819 1013-0258 27.7 µM 0.877241735022836 0.188290139484503 no 627 0.190177675894322 930 5753198 SGTC_585 0kpi-0023 191 µM 0.876626266182084 0.188460236860501 no 628 0.190344833842432 909 64601 SGTC_2367 9070478 135.38 µM 0.876308696060944 0.188548040897439 no 629 0.190431119422298 913 572802 SGTC_2761 levamisole 97.89 µM 0.875586172686954 0.188747903237738 no 630 0.190627522541729 922 26879 An alkaline phosphatase inhibitor. SGTC_298 1391-0729 10 µM 0.875093644429261 0.188884219803756 no 631 0.190761477461224 922 3237558 SGTC_2458 5808907 16.39 µM 0.871528975457456 0.189872617036145 no 632 0.19173269598442 1017 2731747 SGTC_1929 genistein trimethyl ether 50.5 µM 0.870449438811761 0.190172572890804 no 633 0.192027419461792 964 136420 SGTC_3255 9139072 49.47 µM 0.869513677935731 0.19043281520509 no 634 0.192283115009885 979 17646060 SGTC_78 0336-0123 156.75 µM 0.869489410811579 0.190439566987394 no 635 0.192289748741726 865 6765896 SGTC_36 0335-0881 14.2 µM 0.8667720279035 0.191196547377967 no 636 0.193033465639011 963 23828853 SGTC_827 3253-0474 693 µM 0.864900441351667 0.19171898581439 no 637 0.193546717669096 994 5402065 SGTC_800 3448-7362 155 µM 0.864751774098997 0.191760522535174 no 638 0.19358752288742 1115 15991913 SGTC_431 k089-0097 107 µM 0.864740657227289 0.191763628742524 no 639 0.193590574384713 975 5499420 SGTC_618 k072-0232 33.2 µM 0.86389178291047 0.192000906927366 no 640 0.193823670605644 919 5872756 YGL099W LSG1 SGTC_1658 st012944 20 µM 0.862374759722843 0.192425393976821 no 641 0.194240662667264 901 24207260 SGTC_2719 novobiocin 32.65 µM 0.861878848728711 0.192564282060503 no 642 0.194377094707128 922 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication. SGTC_1026 k007-1105 30.6 µM 0.859965821161162 0.193100630967372 no 643 0.194903941701908 963 7066794 SGTC_3326 9140064 16.379 µM 0.858409189710143 0.193537730639016 no 644 0.195333277472524 981 1868434 SGTC_2332 7982454 138.89 µM 0.85584618286152 0.194258732492225 no 645 0.196041433082288 960 2981748 SGTC_400 oxethazaine 37.5 µM 0.855195046737864 0.194442164439281 no 646 0.196221588952276 922 4621 A local anesthetic. SGTC_2907 7721985 69.9 µM 0.854140491197426 0.19473946748038 no 647 0.196513575468856 975 3267881 SGTC_2470 5664817 21.68 µM 0.853820697960026 0.194829679037389 no 648 0.196602172176002 965 2859561 SGTC_757 1066-0008 322 µM 0.853151907509702 0.195018422541334 no 649 0.196787534572718 989 6842497 SGTC_1782 st039423 80.636 µM 0.851613266269521 0.195453073897662 no 650 0.197214387020078 898 2068169 SGTC_754 3474-0146 171 µM 0.849405693538629 0.196077718690251 no 651 0.197827793062313 891 24762078 SGTC_1283 0922-0125 16.4 µM 0.848023594550437 0.196469406773912 no 652 0.198212415356838 1014 3360884 SGTC_534 k292-0788 63.4 µM 0.847488603754868 0.196621150847344 no 653 0.198361418262049 1051 4146317 SGTC_473 2-arachidonoylglycerol 10 µM 0.847319394191074 0.19666915999708 no 654 0.198408559712541 915 5282280 An endocannabinoid. SGTC_307 1501-1223 22.3 µM 0.84523269379844 0.197261794655396 no 655 0.198990465863384 963 2830329 SGTC_2163 5671233 125 µM 0.844477518936278 0.197476534515908 no 656 0.199201310324927 1019 701023 SGTC_2046 4110841 106 µM 0.843550775424426 0.197740254336036 no 657 0.199460240480885 999 44119630 YMR134W ERG29 SGTC_2353 9059630 146.67 µM 0.839200794503031 0.1989809529355 no 658 0.200678320774896 1015 4779114 SGTC_1873 rapamycin 2 nM 0.838986337591034 0.199042241285607 no 659 0.200738488212456 994 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1 SGTC_1988 st071872 53.4 µM 0.838480828391149 0.199186752714915 no 660 0.200880355310474 1006 16414116 SGTC_35 0133-0054 64.071 µM 0.838102826879838 0.199294854424931 no 661 0.200986477701958 942 99677 SGTC_1418 3966-3099 2.4 µM 0.837432768034194 0.199486566137653 no 662 0.201174676634996 997 740335 SGTC_1401 3807-4679 7.6 µM 0.83649391196528 0.199755370553804 no 663 0.201438550136083 958 3291456 SGTC_2203 7227154 166.4 µM 0.836068422734695 0.199877264335183 no 664 0.201558205782788 1019 896304 SGTC_2944 9067346 25.62 µM 0.835564292848875 0.200021744907054 no 665 0.201700031777445 915 6473075 SGTC_1943 st076331 65.2 µM 0.835364831971682 0.200078926517838 no 666 0.201756162261996 1059 24208415 SGTC_3279 9140807 49.47 µM 0.833502793536006 0.200613211162412 no 667 0.202280611493335 1011 45595718 SGTC_1606 st000094 49.2 µM 0.832270522090385 0.200967263967547 no 668 0.202628132739819 1055 1242210 SGTC_1262 0737-0114 49.6 µM 0.831667232911525 0.201140735938306 no 669 0.202798400456825 1057 765919 SGTC_2132 5317594 122.667 µM 0.828943657011006 0.201924999993165 no 670 0.203568145055666 945 794577 SGTC_124 0136-0217 7.121 µM 0.82648379693255 0.202634896937202 no 671 0.204264852877625 1151 3976905 SGTC_1331 1472-0049 76.2 µM 0.826256094157114 0.202700685572908 no 672 0.20432941700706 983 24051409 SGTC_3075 9116269 49.47 µM 0.825468842300228 0.202928239302409 no 673 0.204552732439901 1006 17015205 YNL244C SUI1 SGTC_1798 st045719 60.953 µM 0.825249321580549 0.202991718564186 no 674 0.204615028568466 970 3980186 SGTC_1747 st037496 66.6 µM 0.824568000995774 0.203188812954198 no 675 0.204808447267117 1001 723305 SGTC_146 3448-8650 53.125 µM 0.821426680551189 0.20409901966989 no 676 0.205701635670739 1069 2891488 YIL048W NEO1 SGTC_3217 9129673 49.47 µM 0.821088132979201 0.204197259585915 no 677 0.20579803451584 972 17248312 SGTC_2042 p-Dimethylaminoacetophenone 200 µM 0.821015271986212 0.204218406109889 no 678 0.205818784633932 977 75037 A free radical scavenger. SGTC_2446 5162541 200 µM 0.820492193134839 0.20437025812948 no 679 0.20596778895984 951 1549321 SGTC_1608 st001473 40.5 µM 0.818645375886832 0.204906934412386 no 680 0.206494385119252 957 7292267 SGTC_1963 st076565 50.3 µM 0.816619841790984 0.20549650740969 no 681 0.20707285620526 1017 4914280 SGTC_101 0490-5701 117.494 µM 0.815290907481017 0.205883867461746 no 682 0.207452906076733 957 4661669 SGTC_37 0566-0070 1.56 µM 0.814107178234549 0.206229267380988 no 683 0.207791777005666 1066 1626686 SGTC_3104 9120930 49.47 µM 0.812714449540659 0.206636090668067 no 684 0.208190897377141 958 17014836 SGTC_2007 4011539 71.82 µM 0.811236655933996 0.207068281134403 no 685 0.208614889439737 997 45595301 SGTC_2895 9054447 58.44 µM 0.810784799977078 0.207200536067698 no 686 0.208744632458215 1028 2697450 SGTC_2913 7966556 36.57 µM 0.807295006316301 0.208223654938594 no 687 0.209748270179255 988 2976516 SGTC_3212 9128307 49.47 µM 0.806694228299691 0.208400088066906 no 688 0.209921335104573 894 27243542 SGTC_1163 k060-0048 49.9 µM 0.80555111073887 0.208736035830573 no 689 0.210250862363917 1087 6809982 SGTC_1164 k060-0068 93.7 µM 0.805539238766584 0.208739526526492 no 690 0.210254286298336 1089 5963676 SGTC_845 0330-0138 4.51 µM 0.805169337821112 0.208848305109179 no 691 0.210360983929249 1034 9039800 SGTC_2471 5466956 24.79 µM 0.804082830137306 0.209168012813781 no 692 0.21067456996345 1016 724419 SGTC_3089 9117425 49.47 µM 0.80300999039691 0.209483981239518 no 693 0.210984480110729 1005 9401657 SGTC_153 4077-0274 519.67 µM 0.802562225580658 0.209615938135437 no 694 0.211113904497812 1005 3121976 SGTC_2006 4011487 200 µM 0.802099885084717 0.209752241789814 no 695 0.211247590733058 1056 45595294 SGTC_2633 5,7-dihydroxyisoflavone 100 µM 0.801442536890454 0.209946125796463 no 696 0.211437749012893 1008 5377381 SGTC_106 0092-0003 11.579 µM 0.801036046472163 0.210066072307216 no 697 0.211555389072518 1008 1072148 SGTC_2399 5884133 200 µM 0.799710089423855 0.210457613247019 no 698 0.211939392967153 1041 722445 SGTC_1527 coumarin 137 µM 0.798375319306356 0.210852188908348 no 699 0.212326360648045 991 323 A hepatotoxic, DNA x-linker. SGTC_1266 0828-0227 32.9 µM 0.794087268213908 0.212122725336643 no 700 0.213572314507454 1007 3913820 SGTC_200 k038-0079 37.545 µM 0.793890837585158 0.212181034154388 no 701 0.213629492066256 1015 3436683 SGTC_2520 obtusaquinone 4.71 µM 0.7938605350095 0.212190030059086 no 702 0.213638313415892 1082 5967872 SGTC_95 0471-0001 561.058 µM 0.793542819807588 0.212284363374788 no 703 0.213730815916607 1028 4015405 SGTC_2551 apiole 73.87 µM 0.793354536949578 0.21234027829646 no 704 0.213785645311847 931 10659 A possible DNA adduct former. SGTC_930 2810-3379 265 µM 0.792043288114243 0.21272992238877 no 705 0.214167718021044 1101 1015764 SGTC_991 3996-0057 64.7 µM 0.791364048803786 0.212931925736579 no 706 0.214365791411563 999 715343 SGTC_1685 st024049 53.0905 µM 0.791199543540625 0.212980865847802 no 707 0.21441377891301 1020 1941139 SGTC_510 ag-490 170 µM 0.790058599921413 0.213320475729509 no 708 0.214746773161185 1151 5328779 SGTC_1856 st057054 55.7 µM 0.789400683519389 0.213516452605509 no 709 0.214938928265554 1083 1266018 SGTC_288 1315-0019 35.1 µM 0.788721041097207 0.213719011254157 no 710 0.215137533627 1063 6811474 SGTC_1462 k081-0014 26.5 µM 0.787987549177886 0.213937744584273 no 711 0.215351994388572 872 3270634 SGTC_1077 5-fluorocytosine 377 nM 0.787309585012203 0.214140034935349 no 712 0.215550330031231 1026 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_1234 0326-0494 15.5 µM 0.786548926407207 0.21436713202184 no 713 0.215772983647683 1062 1547813 SGTC_1605 st000082 49.1 µM 0.784699417108999 0.214919892962575 no 714 0.216314912314255 1063 1114022 SGTC_554 4483-2211 187 µM 0.784605078519799 0.214948110012346 no 715 0.216342575768894 1015 747107 SGTC_569 4130-2812 160 µM 0.784550652546286 0.214964390017611 no 716 0.216358536345944 955 743552 SGTC_248 streptozotocin 5.23457 mM 0.783667832971664 0.215228560756632 no 717 0.216617520958634 1106 5300 DNA alkylating agent. SGTC_2793 7325131 81.82 µM 0.783231004844915 0.215359344782208 no 718 0.216745735476612 1025 4176441 SGTC_1488 4013-0813 75.9 µM 0.782680952268543 0.215524093175655 no 719 0.216907245191797 1023 2910057 SGTC_316 k060-0003 58.6 µM 0.782501996431418 0.215577708691673 no 720 0.216959806266117 1052 6152314 SGTC_2045 5106652 78.05 µM 0.777663092652637 0.217030383220051 no 721 0.218383827749903 1073 673349 SGTC_1265 0819-1001 68.8 µM 0.77720038847359 0.217169586120013 no 722 0.218520276533899 1071 3106768 SGTC_2185 6113692 200 µM 0.777168602934659 0.217179150578835 no 723 0.218529651706967 1045 874150 SGTC_3165 9101544 49.47 µM 0.77712791058449 0.217191395505608 no 724 0.21854165428999 1068 5002184 SGTC_2605 digitonin 300 nM 0.77650091304863 0.21738011869565 no 725 0.218726640957631 1155 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_1921 5740136 50 µM 0.771581792714466 0.218864031705416 no 726 0.22018108070817 1096 1774243 SGTC_302 1094-0063 18.9 µM 0.771300463461202 0.218949073944511 no 727 0.22026442886219 1031 5440289 SGTC_2972 9093619 59.92 µM 0.771236134705672 0.218968522375156 no 728 0.220283489794514 1045 25236256 SGTC_172 1112-0046 2.638 µM 0.770642417995748 0.219148066891118 no 729 0.220459455665821 967 2802135 YIL048W NEO1 SGTC_1879 gemcitabine 100 µM 0.769062929929805 0.219626128166639 no 730 0.220927976663335 1078 60750 A nucleoside analog which inhibits DNA replication. SGTC_3194 9111903 49.47 µM 0.766438229715067 0.22042186522985 no 731 0.221707796439769 1082 17087251 SGTC_1587 estradiol valerate 56.1 µM 0.766301676144804 0.220463309696496 no 732 0.221748410609256 1090 13791 A steroid. SGTC_108 0509-0257 621.132 µM 0.765969275781415 0.220564212986174 no 733 0.221847291879242 1083 536624 SGTC_2455 5377712 9.75 µM 0.765624194048206 0.220668993814544 no 734 0.22194997219611 1044 2243908 SGTC_1927 st060202 13.8 µM 0.765546724706857 0.220692520571085 no 735 0.221973027208002 1074 688887 SGTC_276 colchicine 750 µM 0.76305516016504 0.221449952567088 no 736 0.222715250043985 1128 2833 A microtubule depolymerizer. SGTC_2723 salbutamol 83.58 µM 0.762917795296706 0.221491754469972 no 737 0.222756211353138 1048 9884233 β2-adrenoceptor agonist SGTC_395 anisomycin 6.25 µM 0.76188501685643 0.22180618669776 no 738 0.223064316607792 1013 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_715 0868-0130 184 µM 0.760846828407368 0.222122522843188 no 739 0.223374280251193 1099 2876258 SGTC_3214 9129694 49.47 µM 0.758375806271962 0.222876478514185 no 740 0.224113018636486 1059 17158655 SGTC_2826 7992541 19.48 µM 0.757906226959612 0.223019920742053 no 741 0.224253561114279 1160 2985066 SGTC_1250 0485-0349 40.2 µM 0.757656162147501 0.223096329401863 no 742 0.224328424537443 1088 6842794 YDL195W SEC31 SGTC_1274 0865-0114 173 µM 0.755157554221972 0.223860610698129 no 743 0.225077226625672 1103 870624 SGTC_832 4083-0019 164 µM 0.754612583494511 0.22402750534837 no 744 0.225240735588936 1214 1990758 SGTC_931 2812-0076 566 µM 0.753962056551217 0.22422681859568 no 745 0.22543600290962 1152 3450959 SGTC_2247 cerulenin 830 nM 0.753542241059185 0.224355498203526 no 746 0.225562068915097 1158 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12 SGTC_2734 clemastine 41.6 µM 0.752958459914918 0.224534505342817 no 747 0.225737438309605 1047 26987 Clemastine is a selective histamine H1 antagonist. SGTC_85 0868-0259 160.055 µM 0.752291518570942 0.224739111363986 no 748 0.225937883605988 1040 83173 SGTC_2328 6201408 200 µM 0.752131420500899 0.22478824240348 no 749 0.22598601511252 1033 2890418 SGTC_1622 st003707 19.4 µM 0.750368550900636 0.225329635986929 no 750 0.226516383244916 1115 10140899 SGTC_1684 st024538 14.6195 µM 0.749150267992357 0.225704212999744 no 751 0.226883320016169 1117 6732859 SGTC_2036 5160441 105 µM 0.746823068486909 0.226420719172874 no 752 0.227585184423997 1132 134534 YIL048W NEO1 SGTC_689 0833-0039 98 µM 0.746428821847661 0.226542228289215 no 753 0.227704206979158 1134 5374726 SGTC_315 k915-0449 187 µM 0.74626379753427 0.226593100673847 no 754 0.227754038008852 1143 20970215 YNL149C PGA2 SGTC_805 3852-0218 479 µM 0.746232149419844 0.226602857640077 no 755 0.227763595230086 1085 6615355 SGTC_1525 8-methoxypsoralen 92.5 µM 0.745192911540227 0.226923381557748 no 756 0.22807755371804 1161 4114 Related to psoralen; DNA damaging agent. SGTC_2354 9060492 162 µM 0.744242272273661 0.227216803508172 no 757 0.228364959178978 1147 6471895 SGTC_2892 9047358 58.44 µM 0.743705133770809 0.227382689840685 no 758 0.228527441468283 1093 6466771 SGTC_3215 9129942 49.47 µM 0.742549342253078 0.227739868167216 no 759 0.228877283977979 1066 17682944 SGTC_2044 5102272 200 µM 0.741914016274336 0.227936339621068 no 760 0.229069716536291 1103 592666 SGTC_866 0495-0101 262 µM 0.741344112265663 0.22811266075223 no 761 0.229242410765078 1072 635694 SGTC_145 3737-0113 38.366 µM 0.73958874073041 0.22865623228332 no 762 0.229774787804433 1204 6849351 SGTC_1647 st011722 22.4 µM 0.738691801713694 0.228934260586797 no 763 0.230047082564222 1107 2854783 SGTC_2997 9067075 71.4286 µM 0.738365034847439 0.229035597137902 no 764 0.230146328038754 1134 27209819 SGTC_1221 2958-7315 257 µM 0.736159471470954 0.22972024159693 no 765 0.230816826772433 1122 4562705 SGTC_857 0438-0306 1.35 µM 0.735492659313146 0.229927456874416 no 766 0.231019754489652 1128 4686136 SGTC_1829 berberine 14.4 µM 0.733886406253743 0.230427037507329 no 767 0.231508986343501 1131 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_1746 st038117 42 µM 0.733776464332404 0.230461254078717 no 768 0.23154249351255 1119 2898218 SGTC_2319 6033012 152.6 µM 0.730366888766892 0.231523804793682 no 769 0.232582976054468 1090 847246 SGTC_1590 st077108 57.8 µM 0.729694348579125 0.231733715369919 no 770 0.232788518174038 1124 5489485 SGTC_2038 4100038 30.985 µM 0.727545700213415 0.232405053014019 no 771 0.233445865190829 1124 3596803 SGTC_384 k007-0144 5.16 µM 0.727343525939741 0.232468277291245 no 772 0.233507770360943 1145 6824886 SGTC_32 0928-0142 34.1 µM 0.72560952013823 0.233010931141814 no 773 0.234039091617612 1134 2244242 SGTC_2735 sertaconazole 140 nM 0.72546407257961 0.233056480637569 no 774 0.234083689003491 1178 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C SGTC_693 4161-2696 114 µM 0.723220820635957 0.233759620811714 no 775 0.234772114588654 1132 805759 SGTC_2300 7976697 71.57 µM 0.722856198793962 0.233874021357534 no 776 0.234884118062586 1060 2236109 SGTC_2898 9056270 58.44 µM 0.722682803780979 0.233928435135866 no 777 0.234937391395955 1090 19154699 SGTC_2765 myclobutanil 7.74 µM 0.722050047138842 0.234127062501575 no 778 0.235131854165619 1155 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11 SGTC_178 4092-0806 87.505 µM 0.721997666373175 0.234143509426958 no 779 0.235147956136805 1131 2169044 SGTC_616 4092-0450 108 µM 0.721973291829529 0.234151162956268 no 780 0.235155449136759 1193 787165 SGTC_573 3702-0553 84.7 µM 0.721520184456427 0.234293462452038 no 781 0.235294763280468 1135 1222756 SGTC_2974 9094440 9.66 µM 0.72139006572318 0.234334335408266 no 782 0.235334778508561 1149 25236134 SGTC_2417 cerulenin 830 nM 0.720862133332977 0.23450021025366 no 783 0.235497171336232 1158 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1 SGTC_68 0986-0284 82.829 µM 0.720156051875187 0.234722160522502 no 784 0.235714459711737 1078 423278 YIL048W NEO1 SGTC_1640 st009078 66.4 µM 0.720088263133321 0.23474347540454 no 785 0.235735326725803 1131 690618 SGTC_2484 5809818 12.04 µM 0.720071677728406 0.234748690532961 no 786 0.235740432269616 1134 2870548 SGTC_2291 7917025 104.35 µM 0.719300756186512 0.23499117041229 no 787 0.235977815047854 1133 2964612 SGTC_480 am 92016 50 µM 0.718198645604938 0.235338060208426 no 788 0.236317406473931 1096 2129 K+ channel blocker. SGTC_2314 7727897 200 µM 0.71702813163683 0.235706789321173 no 789 0.236678369369848 1168 900724 SGTC_1180 1193-0155 285 µM 0.716806826878174 0.235776539370246 no 790 0.236746649368609 1158 2921347 SGTC_633 0437-0093 97.7 µM 0.71676887699809 0.235788501421897 no 791 0.236758359277515 1192 2831118 SGTC_3288 9119690 36.221 µM 0.715908922090167 0.236059654544678 no 792 0.237023794465417 1143 17595618 YKL019W RAM2 SGTC_452 diindolylmethane 8 µM 0.715458064087887 0.2362018835899 no 793 0.237163022408825 1101 3071 Inhibits expression of several cancer promoting factors. SGTC_943 3253-1379 105 µM 0.714843746242182 0.236395754121651 no 794 0.237352800131898 1139 668464 SGTC_2264 7948757 110.76 µM 0.713633214832608 0.236778037959607 no 795 0.237727006659182 1166 2971411 SGTC_1466 k213-0079 57.5 µM 0.711528900532888 0.237443385380338 no 796 0.238378274142693 1142 3657981 SGTC_1017 4239-0030 168 µM 0.711512878197556 0.237448455297028 no 797 0.238383236665222 1168 1149593 SGTC_70 0141-0289 43.283 µM 0.711341774502607 0.237502601015263 no 798 0.238436235335375 1220 352408 SGTC_808 0711-0032 135 µM 0.710760356149916 0.237686641327807 no 799 0.238616375493669 1158 4252555 SGTC_354 2783-3500 4.88 µM 0.71064233506003 0.237724008898127 no 800 0.238652950919939 1150 6740761 SGTC_2440 5628896 157.78 µM 0.709292109868393 0.238151743396568 no 801 0.239071611854435 1179 5522048 SGTC_109 0132-0036 33.701 µM 0.706272943520982 0.239109701551478 no 802 0.24000920794863 1065 67274 A color developer. SGTC_1955 wogonin 32.4 µM 0.706217878591874 0.23912719276282 no 803 0.24002632684997 1195 5281703 A flavanone. SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM 0.706017831130713 0.239190743129948 no 804 0.240088524355672 1146 5711223 A potent inhibitor of glutathione S-transferases. SGTC_918 glabranin 770.725 nM 0.705537618032613 0.239343333182697 no 805 0.240237865063227 1192 124049 Also referred to as licorice root. SGTC_2091 4-phenylthiadiazole 200 µM 0.705032890084148 0.23950377024481 no 806 0.240394884152372 1178 270010 SGTC_531 3788-1495 174 µM 0.704918607562669 0.239540105197505 no 807 0.240430444802906 1130 2896655 SGTC_1839 st053978 48 µM 0.703204096630896 0.240085577400867 no 808 0.240964283303153 1232 3788398 SGTC_1018 4259-0013 28.1 µM 0.702224152263749 0.240397650878091 no 809 0.241269692857816 1169 6801262 SGTC_2124 5246320 200 µM 0.701223612820341 0.240716510906479 no 810 0.24158173798598 1168 579342 SGTC_1212 0520-0165 585 µM 0.700381306976393 0.240985122117964 no 811 0.241844603511402 1271 5403258 SGTC_3134 9127454 49.47 µM 0.698884467552243 0.241462865962296 no 812 0.242312117581263 1282 24262820 SGTC_2479 5617353 43.85 µM 0.69823097997165 0.241671599754277 no 813 0.242516377550064 1213 2731746 SGTC_1922 5578187 25 µM 0.697081889202107 0.242038874111047 no 814 0.242875773771822 1195 1350412 SGTC_3188 9110789 49.47 µM 0.696440301883239 0.24224407095913 no 815 0.243076565609372 1217 849217 SGTC_75 0159-0059 199.013 µM 0.696361748047843 0.242269201061949 no 816 0.243101156066937 1217 5377270 SGTC_1883 5-benzylidenerhodanine 20 µM 0.69583709678939 0.242437078107016 no 817 0.243265427153527 1195 1273210 SGTC_3224 9130643 49.47 µM 0.695603492341138 0.242511846745149 no 818 0.243338589243805 1225 17644395 SGTC_3109 9122853 49.47 µM 0.695166987485013 0.242651590194394 no 819 0.243475329152822 1224 1234709 SGTC_3311 9131146 2.8755 µM 0.694031841187499 0.243015201991972 no 820 0.243831120367757 1165 4900406 YPR165W RHO1 SGTC_2544 sphondin 68.51 µM 0.693584186667201 0.243158676359582 no 821 0.243971506744795 1220 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31 SGTC_494 Boc-Gly-Val-Val-CHO 140 µM 0.693399871281082 0.243217763199181 no 822 0.244029321511029 1221 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA. SGTC_2695 st077686 51.995 µM 0.693165594473444 0.243292877605361 no 823 0.24410281849321 1189 2876092 SGTC_1222 0366-0074 1.18 µM 0.692412802868744 0.2435343243509 no 824 0.244339063977891 1225 286520 SGTC_3038 9091290 49.47 µM 0.689732958724379 0.244394894078145 no 825 0.24518106764032 1219 25236843 SGTC_1205 4161-2785 76 µM 0.689642504174316 0.244423970018975 no 826 0.245209515541865 1164 3498106 SGTC_1653 st012112 65 µM 0.689024571901865 0.244622649592077 no 827 0.245403902335368 1206 720429 SGTC_2231 micatex 6.853 µM 0.688470981379073 0.244800715632703 no 828 0.245578119047293 1207 20737 An antifungal of unknown mechanism. SGTC_2018 5133068 143 µM 0.68771941689957 0.245042572918295 no 829 0.245814745076594 1206 785362 SGTC_2511 berberine 10.47 µM 0.686815770291065 0.24533354110965 no 830 0.246099415311661 1210 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_3146 9095609 49.47 µM 0.686443647723544 0.245453416060145 no 831 0.246216694177516 1229 17173999 SGTC_3180 9109287 49.47 µM 0.685672867542598 0.245701813993938 no 832 0.246459710038112 1204 18891271 SGTC_2912 7964298 10.93 µM 0.685632136516065 0.245714944062009 no 833 0.246472555517036 1245 2975850 SGTC_347 4534-1311 26.2 µM 0.685225595454031 0.245846017426271 no 834 0.24660078737754 1223 2862016 SGTC_1678 st019265 80.2 µM 0.684832640053731 0.245972746282337 no 835 0.24672476798197 1224 5367020 SGTC_2993 9054257 71.4286 µM 0.683236176451071 0.246487969077302 no 836 0.247228808212889 1221 6470217 YGL055W OLE1 SGTC_1957 st077035 62.4 µM 0.682976415522882 0.246571855750463 no 837 0.247310872756966 1277 705593 SGTC_2565 isoliquiritigenin 100 µM 0.681592567301264 0.247019010559075 no 838 0.247748308063567 1173 638278 Binds to benzodiazepine receptor 65X better than valium. SGTC_2143 5623677 140.463 µM 0.681253892416443 0.247128510646098 no 839 0.247855426302437 1196 5375313 SGTC_2341 7987486 176.74 µM 0.678738222376206 0.247942687049597 no 840 0.248651871617648 1226 1258686 SGTC_2251 lansoprazole 556 µM 0.678241816869636 0.24810351364029 no 841 0.248809191351244 1130 3883 Gastric proton pump inhibitor. YBR192W RIM2 SGTC_187 1488-2104 32.728 µM 0.677336787266103 0.24839687035186 no 842 0.249096147649591 1255 2852859 SGTC_2352 9027995 87.8 µM 0.676665133353684 0.248614700015821 no 843 0.249309221645297 1197 2997347 SGTC_505 gw-5074 63.9 µM 0.67661568782595 0.248630740126191 no 844 0.249324911463156 1228 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases. SGTC_2240 6690706 185.951 µM 0.676437017173525 0.24868870541223 no 845 0.249381610753448 1168 805876 SGTC_2178 5812956 200 µM 0.675209925680775 0.249086999353529 no 846 0.249771200696766 1220 5403383 SGTC_1732 st034308 51.822 µM 0.67477495269212 0.24922826593347 no 847 0.249909378046095 1151 830119 SGTC_54 0159-0055 9 µM 0.674490759476595 0.249320586633202 no 848 0.249999679274407 1275 3319099 SGTC_2077 5212015 200 µM 0.674490759476595 0.249320586633202 no 849 0.249999679274407 1152 780900 SGTC_2090 5301565 104.445 µM 0.674456555632571 0.249331699041785 no 850 0.25001054857271 1250 2056344 SGTC_1793 st048256 72.231 µM 0.674417486637613 0.249344392400258 no 851 0.250022964225566 1167 672022 SGTC_1394 3474-0001 65.7 µM 0.674301898872263 0.249381948409339 no 852 0.250059698531442 1170 5017666 YIL048W NEO1 SGTC_2811 7967822 32.47 µM 0.674114996651396 0.249442681798802 no 853 0.250119102946282 1238 2232244 SGTC_944 3370-0224 231 µM 0.672957105185287 0.249819110740892 no 854 0.250487290313549 1238 4580514 SGTC_169 k015-0017 16.025 µM 0.672619580262777 0.249928896376001 no 855 0.250594670828352 1278 1840002 SGTC_614 0462-0418 107 µM 0.671336154671465 0.250346585739312 no 856 0.251003203678398 1131 5188303 SGTC_128 0906-2981 13.371 µM 0.6709343821833 0.250477418140628 no 857 0.251131166039579 1223 6740226 SGTC_894 0960-0238 55.9 µM 0.670895386478013 0.250490118554009 no 858 0.251143587797363 1220 6741907 YDL195W SEC31 SGTC_591 4299-0174 154 µM 0.669358883616387 0.250990809810478 no 859 0.251633286577683 1210 5509088 SGTC_2125 5246583 200 µM 0.667924751236561 0.251458619597148 no 860 0.252090813537429 1274 835267 SGTC_481 bay k-8644 50 µM 0.667341424016108 0.251649030974509 no 861 0.252277036147805 1185 2303 A calcium channel antagonist. SGTC_1413 3910-0535 34.4 µM 0.666998348286422 0.251761054313985 no 862 0.252386594230548 1251 2876951 SGTC_1543 azetidyl-2-carboxylic acid 198 µM 0.666923663050135 0.251785444517169 no 863 0.252410447598175 1243 16486 A toxic proline analog. SGTC_2762 leflunomide 42.06 µM 0.666414502731829 0.251951755915199 no 864 0.252573097583373 1240 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1 SGTC_1134 3477-0009 42.5 µM 0.666163708395588 0.252033696324093 no 865 0.252653233496319 1299 3973534 SGTC_1156 4092-0367 4.88 µM 0.665759835876995 0.252165680522767 no 866 0.252782310377136 1235 1357585 SGTC_1245 0418-0076 17.2 µM 0.665555117920885 0.252232595590844 no 867 0.252847751099809 1243 6790114 SGTC_742 0kpi-0133 140 µM 0.665039949593155 0.252401027339119 no 868 0.253012470719458 1254 2728852 SGTC_2244 6635614 200 µM 0.664351490711824 0.252626208092907 no 869 0.253232686271757 1158 836499 SGTC_1952 st077036 64.1 µM 0.663306144399742 0.252968321606242 no 870 0.253567251077666 1256 2937007 SGTC_2589 lobaric acid 100 µM 0.662812863213788 0.253129843793649 no 871 0.253725207135074 1229 73157 A novel microtubule depolymerizer. SGTC_1876 myriocin 605 nM 0.662379465940244 0.253271802081577 no 872 0.25386403009087 1285 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1 SGTC_2177 5811945 192 µM 0.662075580628212 0.253371363980671 no 873 0.253961392401915 1285 5343475 SGTC_177 1327-0068 8.361 µM 0.660668946833319 0.253832487065641 no 874 0.254412321237396 1260 15389900 YOR207C | YLR033W RET1 | RSC58 SGTC_1976 st070609 63.5 µM 0.657846503672196 0.254759068296334 no 875 0.255318384439425 1206 682556 SGTC_1975 st070967 30.8 µM 0.656515185297154 0.255196741298968 no 876 0.255746350152756 1258 261391 SGTC_1679 SEC14.276 6.7 µM 0.656504834615375 0.255200145641484 no 877 0.255749678950364 1277 1005053 YMR079W SEC14 SGTC_3306 9127676 59.7925 µM 0.65545492956154 0.255545583075303 no 878 0.256087447755146 1257 41905287 SGTC_1307 1187-1599 12.2 µM 0.655043198896445 0.255681116431324 no 879 0.25621997062123 1251 1538471 SGTC_1714 st033236 13.627 µM 0.653094114627709 0.256323224370025 no 880 0.256847803119146 1311 2916566 SGTC_213 1246-0773 967 nM 0.651362320707692 0.256894452361439 no 881 0.257406313759086 1252 6251622 SGTC_1182 1222-0449 220 µM 0.649965896633962 0.257355541383439 no 882 0.257857125372545 1269 658318 SGTC_833 3852-0053 558 µM 0.649206629319755 0.257606426271418 no 883 0.258102413660521 1324 3123681 SGTC_1136 pergolide 1.05886 µM 0.649098732229046 0.257642089037854 no 884 0.258137280623943 1260 47811 A dopamine receptor agonist. SGTC_1540 guanosine 70.6 µM 0.64870512303441 0.257772208740913 no 885 0.258264496204553 1217 6802 Guanosine is a purine nucleoside SGTC_2767 sibutramine 71.45 µM 0.647849043079759 0.258055330191752 no 886 0.258541295765517 1335 64765 A serotonin-norepinephrine reuptake inhibitor.  SGTC_2780 5215298 71.43 µM 0.647795448515127 0.25807306026669 no 887 0.258558629807149 1264 2834131 SGTC_838 0109-0203 71.4 µM 0.647528852798581 0.258161264454956 no 888 0.258644863560828 1272 759422 SGTC_3198 9112019 49.47 µM 0.64731591834277 0.258231725840316 no 889 0.258713750596045 1309 45595555 SGTC_594 1487-1584 10.8 µM 0.6467469173209 0.258420060847957 no 890 0.258897876330036 1244 5013332 SGTC_1184 1269-1718 139 µM 0.64580796544927 0.258731002300113 no 891 0.259201864383481 1298 5403821 SGTC_2782 7736369 71.43 µM 0.645539076534952 0.258820082678801 no 892 0.259288951821929 1309 2950836 YOL077C BRX1 SGTC_936 3005-4620 401 µM 0.644918882753418 0.259025607571481 no 893 0.259489877126395 1313 777207 SGTC_696 1560-0013 611 µM 0.644407710262811 0.259195067524784 no 894 0.259655543035689 1314 1650269 SGTC_1172 0370-0043 85 µM 0.641957645361015 0.260008088955214 no 895 0.260450341942576 1316 376585 SGTC_1112 tnp00069 1.16933 µM 0.640504272204519 0.260490992170952 no 896 0.26092240628372 1338 145826 SGTC_2267 7931562 200 µM 0.639956483335298 0.260673122321318 no 897 0.261100445515395 1213 934880 SGTC_2839 9003951 25.97 µM 0.639218001920251 0.260918758074753 no 898 0.261340561354238 1275 2990634 SGTC_1718 roemerine 11.9335 µM 0.636809264131962 0.261720785742565 no 899 0.262124545482416 1232 235224 An aporphine alkaloid with mutagenic activity. SGTC_2334 9017922 200 µM 0.63595427934086 0.262005770434646 no 900 0.262403111269155 1319 3163164 SGTC_981 1488-1094 54.9 µM 0.635644595918962 0.262109033765664 no 901 0.262504047764281 1259 3449522 SGTC_1347 1493-0251 600 nM 0.635097768471896 0.262291423225446 no 902 0.262682326184924 1310 3986378 SGTC_889 0919-1524 82.7 µM 0.634462362484724 0.262503438900876 no 903 0.262889561044091 1272 3905452 SGTC_2836 9010338 19.48 µM 0.63418407291515 0.262596323293158 no 904 0.262980350275465 1187 2994051 SGTC_695 3505-6186 243 µM 0.632984794105805 0.262996797544838 no 905 0.263371786450976 1308 1819379 SGTC_3182 9108849 49.47 µM 0.632116098849085 0.263287075119728 no 906 0.263655508141661 1302 17133045 SGTC_1299 1079-1439 3.74 µM 0.632085286802822 0.263297374077246 no 907 0.263665574424937 1258 323161 SGTC_2758 dehydroepiandrosterone 69.35 µM 0.630873053466805 0.263702727498317 no 908 0.264061766102498 1334 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem] SGTC_853 0419-0306 21 µM 0.630037628690595 0.2639822667034 no 909 0.26433498267601 1242 762713 SGTC_3020 9089140 49.47 µM 0.629103644572568 0.264294963278945 no 910 0.264640602304759 1304 17217859 SGTC_1467 k284-1082 293 µM 0.629089687270528 0.264299637593958 no 911 0.264645170795854 1316 3334705 SGTC_152 4469-0003 551.229 µM 0.62834478476452 0.264549167275212 no 912 0.264889049775399 1288 697280 SGTC_2976 9009005 19.48 µM 0.62786668629198 0.264709385267987 no 913 0.26504563802939 1321 2993148 SGTC_2545 solidagenone 89.61 µM 0.627270743285147 0.264909163801441 no 914 0.265240888900127 1172 6708572 An anti ulcer agent SGTC_1321 1326-2144 215 µM 0.625184304298754 0.265609205954639 no 915 0.265925051055158 1283 3513030 SGTC_2591 skatole 100 µM 0.623978739344063 0.266014124426947 no 916 0.266320773856401 1317 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite. SGTC_1634 st006576 41 µM 0.622144591626287 0.266630766953606 no 917 0.266923397978035 1309 3915356 SGTC_750 4073-0104 132 µM 0.619028625673904 0.267680012422303 no 918 0.267948750574381 1194 22330957 SGTC_2099 5377090 177.372 µM 0.616635980155558 0.268487102777057 no 919 0.268737428385282 1302 2243829 SGTC_350 k064-0020 19.8 µM 0.6161311193371 0.268657559273407 no 920 0.268903992432643 1347 2790705 SGTC_1596 piperlongumine 63 µM 0.614839645904363 0.269093847639764 no 921 0.269330312048526 1361 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_391 gliotoxin 8.33 µM 0.61400528673843 0.269375901593311 no 922 0.269605916841331 1367 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion SGTC_2303 7774051 200 µM 0.611109578425585 0.270355940232962 no 923 0.270563519539749 1369 2953184 SGTC_810 3825-7150 143 µM 0.611034530283505 0.270381363592719 no 924 0.270588360321818 1350 22330411 YGL099W LSG1 SGTC_1421 4029-0249 71.4 µM 0.610904714838255 0.270425342782404 no 925 0.270631331659006 1414 2894095 SGTC_1940 st075990 51.1 µM 0.61089153145837 0.270429809279598 no 926 0.270635695794628 1413 1084979 SGTC_1187 1391-0724 117 µM 0.610325790830373 0.270621515565195 no 927 0.270823007800792 1341 6997986 SGTC_2706 st078239 82.5 µM 0.609951227881719 0.270748476914602 no 928 0.27094705806486 1319 15434492 SGTC_3110 9122132 49.47 µM 0.608334554678439 0.271296803213258 no 929 0.271482803763593 1405 918317 SGTC_2842 9000675 19.48 µM 0.607816688354842 0.271472564662954 no 930 0.271654529839507 1270 2989072 SGTC_3022 9087993 49.47 µM 0.60774886416034 0.271495588082959 no 931 0.271677024556863 1363 17173644 SGTC_2769 toremifene 3.73 µM 0.606451564163002 0.271936153204057 no 932 0.272107468260683 1352 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_2701 st077767 14.721 µM 0.605807169975917 0.272155122597885 no 933 0.272321403998989 1326 5721188 SGTC_885 0865-0106 16.8 µM 0.605352272004234 0.272309752684268 no 934 0.272472478215757 1284 2793380 SGTC_2122 5258151 111.688 µM 0.605248232776789 0.272345124097801 no 935 0.272507036084846 1311 2173356 SGTC_664 1222-0054 14.9 µM 0.600564089987705 0.273940006754321 no 936 0.274065180903675 1326 6813991 SGTC_3191 9110352 49.47 µM 0.599431840327881 0.274326213030097 no 937 0.274442474794685 1363 17122424 SGTC_2232 chlorophetanol 41.5365 µM 0.599409980590447 0.27433367195189 no 938 0.274449761527152 1397 15907 An antifungal of unknown mechanism. YFR051C RET2 SGTC_830 4076-0286 57.8 µM 0.599136912710257 0.274426855888234 no 939 0.274540794114263 1385 6866659 SGTC_2731 amoxapine 43.43 µM 0.598949515211483 0.274490813994533 no 940 0.274603275401174 1385 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine. SGTC_3028 9087778 49.47 µM 0.598923550046563 0.274499676394006 no 941 0.274611933150629 1280 17217395 SGTC_1859 st055998 20 µM 0.598825815230697 0.274533036391983 no 942 0.274644522771978 1389 676301 SGTC_3100 9120536 49.47 µM 0.594992322070731 0.275843105079246 no 943 0.275924301627988 1270 16421196 SGTC_2752 diclazuril 33.15 µM 0.594578321901569 0.275984770217904 no 944 0.276062687098384 1373 456389 An antifungal agent for coccidioides. YHR062C RPP1 SGTC_517 1365-0151 113 µM 0.593582916704026 0.27632553029017 no 945 0.276395554905967 1373 768657 SGTC_2715 st079500 56.4 µM 0.591035500868812 0.277198533752539 no 946 0.277248317268309 1304 28246688 SGTC_2294 7971431 200 µM 0.587573412319472 0.278387155772433 no 947 0.278409330736863 1351 5741572 SGTC_1659 st012954 42.1 µM 0.586353300179494 0.278806642081122 no 948 0.278819059950462 1354 24207262 SGTC_2492 derrusnin 100 µM 0.584979006778017 0.279279505487628 no 949 0.279280916332612 1299 1715307 Part of coumarin class of compounds. SGTC_1986 st071812 45 µM 0.584898822140022 0.279307107243659 no 950 0.279307875317967 1368 11838594 SGTC_3079 9117512 49.47 µM 0.584657817728542 0.279390075563504 no 951 0.279388911347246 1424 7185044 SGTC_2712 st079126 47.7 µM 0.584479077132412 0.279451616636904 no 952 0.279449018984075 1315 3152970 SGTC_284 0988-0104 32.6 µM 0.584135530906556 0.279569919405409 no 953 0.279564565782202 1371 4666532 SGTC_3101 9120531 49.47 µM 0.583286319223042 0.279862456229197 no 954 0.279850285325814 1414 24824904 SGTC_1215 3852-0577 11.2 µM 0.582188944230172 0.280240700207591 no 955 0.280219709717705 1465 2884876 SGTC_2051 5263410 176 µM 0.582059108936718 0.280285468304929 no 956 0.280263433577721 1393 227584 SGTC_224 benfluorex 43.875 µM 0.582039392812995 0.280292266862191 no 957 0.28027007354852 1371 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis. SGTC_2155 5570423 76 µM 0.580615809662463 0.280783360907211 no 958 0.280749707320986 1358 797402 SGTC_2655 perillic acid 100 µM 0.578602072320444 0.281478750429902 no 959 0.281428853059185 1339 5702197 An apoptosis inducer. SGTC_1146 3579-1023 7 µM 0.578052528824448 0.281668664570608 no 960 0.281614327697389 1473 X1146 SGTC_1869 3',7'-dimethoxyflavone 40.3 µM 0.577474217768601 0.281868587050283 no 961 0.281809575216529 1357 688664 SGTC_2733 amorolfine 100 µM 0.577130578176757 0.281987415840321 no 962 0.281925624602797 1415 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_2081 5214970 32.255 µM 0.576244033819783 0.282294089657797 no 963 0.282225122824749 1382 2063512 SGTC_2256 7954252 200 µM 0.576151098324507 0.282326247236519 no 964 0.282256527767793 1319 2972920 SGTC_495 decylubiquinone 155 µM 0.574823199718687 0.282785919659476 no 965 0.2827054374276 1324 2971 A Co-enzyme Q analog. A free radical scavenger. SGTC_1990 st072050 59.8 µM 0.574717816878926 0.282822414935141 no 966 0.282741077859114 1365 17233948 SGTC_2433 5607874 27.82 µM 0.573173577549566 0.283357461876479 no 967 0.283263586380785 1348 2252428 SGTC_3336 9143619 71.43 µM 0.571251457280269 0.284024113975886 no 968 0.283914600899 1405 45595730 SGTC_624 k048-0052 28 µM 0.570899102770729 0.284146402999726 no 969 0.284034019595254 1360 6835531 SGTC_2379 9035213 200 µM 0.569930412867406 0.284482728608458 no 970 0.284362448202877 1493 646551 SGTC_2347 9049783 174.81 µM 0.56983160169829 0.284517046171885 no 971 0.284395959745366 1429 6467988 YPL169C MEX67 SGTC_2897 9048598 12.99 µM 0.569587050460808 0.284601988418059 no 972 0.284478906754042 1350 6467404 SGTC_1633 st005664 67.9 µM 0.569073666918647 0.28478034606043 no 973 0.284653074021045 1373 2063822 SGTC_423 5-fluorouracil 457 µM 0.567515036407102 0.285322165746667 no 974 0.285182156852429 1315 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_2841 9004761 38.96 µM 0.564008673061686 0.286542858694983 no 975 0.286374114809135 1295 2991039 SGTC_1486 3970-0793 4.53 µM 0.563316340723774 0.286784177399658 no 976 0.286609746473071 1431 2844330 SGTC_292 k038-0015 474 µM 0.561687588034843 0.287352273474475 no 977 0.287164446203245 1401 46368540 SGTC_603 3794-0023 45.9 µM 0.560568626171489 0.287742866798408 no 978 0.287545822171347 1431 3802260 SGTC_2165 5727197 32.143 µM 0.559987239327524 0.287945909081503 no 979 0.287744070838184 1498 1361712 SGTC_3292 9120825 59.784 µM 0.558456176780958 0.288480937438734 no 980 0.288266460709237 1440 24824900 SGTC_921 1561-0023 372 µM 0.557458326807801 0.288829887152019 no 981 0.288607162039215 1389 24050882 SGTC_1656 st012921 11 µM 0.557442502152566 0.288835422659058 no 982 0.288612566664743 1410 6732821 SGTC_2810 7959871 45.46 µM 0.557157104520551 0.288935264090242 no 983 0.288710047260175 1453 2974535 SGTC_661 1304-0007 33.6 µM 0.556998013361922 0.28899092643216 no 984 0.288764393266239 1392 3117130 SGTC_3241 9133421 49.47 µM 0.556566962056527 0.289141766728338 no 985 0.288911665854747 1415 17018221 SGTC_2179 6298986 200 µM 0.55605468026719 0.289321080609155 no 986 0.289086737525601 1468 738374 SGTC_2517 totarol 10 µM 0.554090978710811 0.290008918253562 no 987 0.289758291876979 1347 460178 An antibacterial membrane disruptor. YGL001C ERG26 SGTC_2073 5212005 126 µM 0.554085826293551 0.290010724029958 no 988 0.289760054883256 1307 691789 SGTC_1526 st051518 75 µM 0.552355822551168 0.290617339169026 no 989 0.290352295850119 1406 673993 SGTC_3126 9127922 49.47 µM 0.551341445886697 0.29097329993627 no 990 0.29069981596872 1423 45595682 SGTC_1648 st011736 69.8 µM 0.55125957538505 0.291002038468778 no 991 0.290727872854686 1465 2855514 SGTC_2191 5911152 200 µM 0.551149051283179 0.291040837213586 no 992 0.290765751290814 1410 2875902 SGTC_1373 2887-0003 58.5 µM 0.550852011953682 0.291145122850921 no 993 0.290867563010683 1404 776948 SGTC_3016 9080866 49.47 µM 0.550547737387282 0.291251966750198 no 994 0.290971871918163 1385 17066299 SGTC_713 1488-1073 324 µM 0.548807778599055 0.291863292482923 no 995 0.291568685774863 1395 3312542 SGTC_908 3448-7491 47.7 µM 0.548655956331378 0.291916662809718 no 996 0.291620788574337 1401 1203031 SGTC_954 1189-0853 2.85 µM 0.548478748243023 0.291978962803057 no 997 0.291681608841709 1393 2828194 SGTC_774 k060-0086 136 µM 0.548327093694144 0.29203228400617 no 998 0.291733663475343 1447 5911235 SGTC_1774 st048371 48.465 µM 0.547635908893473 0.29227535953029 no 999 0.291970963867843 1371 4242727 SGTC_52 0329-0193 875 nM 0.547070311014569 0.29247433869542 no 1000 0.292165214085234 1487 3739292 SGTC_1964 st076914 61 µM 0.546730190569495 0.292594024478126 no 1001 0.292282054768614 1417 24208661 SGTC_2528 xanthyletin 44.79 µM 0.545742806525605 0.292941606225817 no 1002 0.292621371284886 1452 65188 An natural product with antifungal activity of unknown mechanism. SGTC_2606 farnesol 9.78 µM 0.544303585521039 0.293448587819732 no 1003 0.293116290001966 1484 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_1409 3909-8004 61.9 µM 0.543643897934056 0.293681105870811 no 1004 0.293343272771186 1422 2119279 SGTC_3343 9148379 18.9835 µM 0.543406878054151 0.293764668356015 no 1005 0.293424845545691 1529 1955036 SGTC_1919 st067113 52.3 µM 0.542820286088785 0.293971521433258 no 1006 0.293626772240523 1413 1268243 SGTC_1433 4060-0023 7.6 µM 0.542576692796298 0.294057440831282 no 1007 0.293710644979706 1445 3840627 SGTC_2893 9048488 25.97 µM 0.541767461320714 0.294342953504063 no 1008 0.293989354799643 1353 6467338 SGTC_1135 dihydrocapsaicin 536.708 nM 0.54152231394225 0.294429471544806 no 1009 0.294073810863714 1357 107982 A Capsaicinoid. SGTC_844 0330-0132 15.3 µM 0.541315126719928 0.294502601742324 no 1010 0.294145197964397 1453 2828079 SGTC_2786 7743617 45.45 µM 0.539398893222792 0.295179365371054 no 1011 0.294805822284495 1334 583674 SGTC_983 1491-0821 12.2 µM 0.537714524257275 0.2957748311345 no 1012 0.295387075210033 1470 46495113 SGTC_3173 9105693 49.47 µM 0.53626054037828 0.296289293495218 no 1013 0.295889248957279 1462 17096658 SGTC_1446 4239-0190 62 µM 0.534833028204724 0.296794788237851 no 1014 0.296382661041997 1408 1340085 SGTC_3285 9112818 20.8695 µM 0.533799403289585 0.297161050230625 no 1015 0.296740163330573 1451 17017947 YPR165W RHO1 SGTC_2799 7812892 81.82 µM 0.531521856106306 0.297968820829374 no 1016 0.297528599920709 1499 20205235 SGTC_3091 9116372 49.47 µM 0.531260044873836 0.298061740712549 no 1017 0.297619294451104 1421 17169793 SGTC_720 r052-1644 49.9 µM 0.529797167114346 0.29858117604654 no 1018 0.298126284788326 1423 1422863 YOR257W CDC31 SGTC_160 3453-0671 289.699 µM 0.529726681221808 0.298606214411701 no 1019 0.298150723054813 1364 5322268 SGTC_3239 9133757 49.47 µM 0.529200712439036 0.298793081916351 no 1020 0.298333111261276 1495 17036923 SGTC_984 1492-0255 2.91 µM 0.529157747081062 0.298808349103927 no 1021 0.298348012439729 1469 1585198 SGTC_2887 9044784 58.44 µM 0.528836104548579 0.298922651901357 no 1022 0.298459574761147 1418 6465546 SGTC_94 0334-0113 514.748 µM 0.528587093970273 0.29901115696336 no 1023 0.298545957585692 1381 6795178 SGTC_851 0394-0702 453 µM 0.52779007255542 0.299294519792358 no 1024 0.29882252411538 1477 762646 SGTC_1628 st004252 77.7 µM 0.52700203478208 0.299574808395195 no 1025 0.299096087725738 1541 692968 SGTC_3329 9141233 27.5565 µM 0.526771945719544 0.299656668707253 no 1026 0.299175983501103 1524 4909101 YNL103W MET4 SGTC_2457 5731572 11.68 µM 0.526437871526626 0.299775542533882 no 1027 0.299292004152128 1558 2865357 SGTC_928 2764-0428 58.7 µM 0.523990844947945 0.300646919803453 no 1028 0.300142453751598 1502 662578 SGTC_776 4476-4378 112 µM 0.523594424515415 0.300788191225813 no 1029 0.300280330126043 1439 2892008 SGTC_586 0957-0265 8.15 µM 0.523284096526908 0.300898802979884 no 1030 0.300388283228873 1380 6752309 YPR165W | YPR107C RHO1 | YTH1 SGTC_2822 7994718 71.43 µM 0.520929525973841 0.301738651224553 no 1031 0.301207933025724 1472 1018011 SGTC_3243 9134147 49.47 µM 0.520606811490694 0.301853841844841 no 1032 0.301320351658983 1496 24282180 SGTC_103 0844-0104 51.839 µM 0.518854326588928 0.302479723497731 no 1033 0.301931165018223 1487 5375804 SGTC_1030 k029-0042 36.7 µM 0.518729397917842 0.302524362675204 no 1034 0.301974729052641 1491 6080581 SGTC_3108 9121785 49.47 µM 0.518043591514797 0.302769465762747 no 1035 0.302213927743749 1527 17140271 SGTC_358 0075-0058 9.45 µM 0.516653690352808 0.30326648064596 no 1036 0.30269896442369 1589 1069125 SGTC_2135 5326629 150.42 µM 0.516584582332098 0.303291202505193 no 1037 0.302723090291033 1423 5020077 SGTC_1966 st070145 16.1 µM 0.515484087284967 0.303685001485163 no 1038 0.303107393217583 1397 3748532 SGTC_2823 7987624 58.44 µM 0.514447459633158 0.304056154876506 no 1039 0.303469592527742 1473 2239440 SGTC_2060 5238662 140 µM 0.514421207602224 0.304065556758528 no 1040 0.303478767537706 1441 790130 SGTC_1342 1486-1464 234 µM 0.513826450678682 0.304278597254001 no 1041 0.303686666580423 1459 3253938 SGTC_1942 st076330 65.2 µM 0.513562670135064 0.304373104082568 no 1042 0.303778892194068 1477 24208414 SGTC_1217 1183-1422 255 µM 0.512327437455977 0.304815834833468 no 1043 0.304210932870093 1555 2849664 SGTC_1928 4'-methoxychalcone 40.3 µM 0.512256996067231 0.304841090983648 no 1044 0.304235579022706 1617 641818 SGTC_841 0251-0215 91.2 µM 0.511197445300911 0.305221095877743 no 1045 0.304606403687769 1497 3888614 SGTC_1140 3229-1848 2.98 µM 0.510995330749699 0.30529360755934 no 1046 0.304677163154184 1499 2849525 SGTC_1913 st060213 96.1 µM 0.510724171050798 0.305390902244712 no 1047 0.304772106519963 1529 688959 SGTC_156 3474-0145 5.642 µM 0.51057609786244 0.305444038120669 no 1048 0.304823958149064 1480 2265471 SGTC_3150 9097574 49.47 µM 0.509392687406883 0.305868850670882 no 1049 0.305238500502378 1562 17217476 SGTC_2598 perillyl alcohol 100 µM 0.50769800557302 0.306477650892191 no 1050 0.305832573668412 1526 10819 An apoptosis inducer. SGTC_123 0083-0120 66.675 µM 0.506611340271959 0.306868307659526 no 1051 0.306213774909729 1404 16001701 SGTC_2981 9013952 38.96 µM 0.505777776448239 0.307168123054352 no 1052 0.306506330661313 1360 2996344 SGTC_1740 st038286 13.222 µM 0.504297778453358 0.307700764891292 no 1053 0.307026069177922 1509 716786 SGTC_712 r015-0009 80.6 µM 0.503668499136211 0.307927361456089 no 1054 0.30724717406165 1530 6813872 YLR060W FRS1 SGTC_3268 9137683 49.47 µM 0.50135925326198 0.308759522681016 no 1055 0.308059155508886 1497 1953228 SGTC_1195 1502-0147 41.1 µM 0.50131305518567 0.308776180689435 no 1056 0.308075409372735 1450 817940 SGTC_666 0272-0154 136 µM 0.500962682675093 0.308902530101648 no 1057 0.308198693144489 1482 6870312 SGTC_1607 st000305 50.6 µM 0.49936831605144 0.309477767292657 no 1058 0.308759967851335 1524 5457690 SGTC_2297 7971671 152.32 µM 0.499087784594309 0.309579029598226 no 1059 0.308858771349092 1567 909016 SGTC_691 1548-0686 185 µM 0.498321197720278 0.309855815074934 no 1060 0.309128834653998 1441 46495133 SGTC_536 3852-0578 10.6 µM 0.498212774642818 0.309894971247269 no 1061 0.309167039693449 1579 2869208 SGTC_1008 4106-0037 6 µM 0.497804026533661 0.310042606915451 no 1062 0.309311088816589 1478 2905394 SGTC_1302 1159-0335 255 µM 0.497620907498206 0.31010875758898 no 1063 0.309375632291358 1471 649284 SGTC_1854 st056233 32.9 µM 0.497138005117724 0.310283232701421 no 1064 0.30954586779946 1535 5393174 SGTC_2078 5212016 200 µM 0.496855686673512 0.3103852555922 no 1065 0.309645411246299 1499 1899708 SGTC_476 mead acid 10 µM 0.496336636362919 0.31057286558334 no 1066 0.309828461074412 1510 5312531 An omega 9 fatty acid. SGTC_227 fluconazole 33.516 µM 0.496299273704795 0.31058637216445 no 1067 0.309841639320813 1444 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C SGTC_939 1165-0479 45.3 µM 0.495517611893597 0.310869001021856 no 1068 0.310117396594685 1463 1377347 SGTC_1513 0337-0559 19 µM 0.49520443509209 0.310982269046012 no 1069 0.310227910138733 1426 775073 SGTC_2956 9076196 2.52 µM 0.4948764796828 0.311100901310405 no 1070 0.310343657117128 1508 16423868 SGTC_1379 2144-0755 36.5 µM 0.49428966705407 0.311313219726728 no 1071 0.310550810772651 1537 5392327 SGTC_2503 beta-caryophyllene alcohol 24.72 µM 0.493739113806401 0.311512475993411 no 1072 0.310745218963623 1453 61125 An anti-inflammatory. SGTC_3166 9102297 49.47 µM 0.491499619839531 0.312323562430131 no 1073 0.31153656045836 1436 25237072 SGTC_746 1095-0025 46.6 µM 0.491454789186831 0.312339808231762 no 1074 0.311552410603589 1580 6749286 SGTC_1288 0973-0013 65.5 µM 0.490338637524973 0.312744398547304 no 1075 0.311947145214204 1540 4315430 SGTC_1844 rapamycin 4 nM 0.489921130157132 0.312895797515847 no 1076 0.312094855082648 1481 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2 SGTC_846 0335-0850 148 µM 0.489263189616557 0.31313444782427 no 1077 0.312327689087687 1491 6819598 SGTC_684 1140-0066 328 µM 0.487984727435559 0.31359839956081 no 1078 0.31278032946542 1477 6813534 SGTC_181 1447-1644 8.07 µM 0.487664334740097 0.313714715779625 no 1079 0.312893808998312 1519 534600 SGTC_2939 9044578 71.43 µM 0.48616778373722 0.314258272784155 no 1080 0.313424105442789 1456 2653634 SGTC_2871 9038510 12.99 µM 0.486068534518055 0.314294335006231 no 1081 0.313459287636227 1632 4945164 SGTC_1816 st051957 91.6 µM 0.485332588433338 0.31456179643754 no 1082 0.313720221190459 1507 674121 SGTC_1673 st016611 27.3 µM 0.485186926900348 0.314614745069133 no 1083 0.313771877307087 1578 5226799 SGTC_2597 laccaic acid a 100 µM 0.484228959010845 0.314963065715118 no 1084 0.314111693479392 1524 5491415 A textile dye. SGTC_2680 butyl paraben 22.24 µM 0.484068638207485 0.315021375038744 no 1085 0.314168578853653 1523 7184 An antifungal and steroid mimetic. SGTC_331 k048-0133 24.5 µM 0.483714263640578 0.31515027885606 no 1086 0.314294334467009 1484 6813582 SGTC_545 4218-0007 221 µM 0.483568724193496 0.315203225380248 no 1087 0.314345987766882 1500 2840508 SGTC_773 4358-1457 44.6 µM 0.479823201209656 0.316567131369774 no 1088 0.315676556904099 1645 1186886 SGTC_1420 4'-methoxyflavone 42 µM 0.478453458863884 0.317066538288036 no 1089 0.316163746114138 1564 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13 SGTC_1235 benzylparaben 21.5 µM 0.478232828194215 0.317147011245214 no 1090 0.31624224979466 1492 7180 SGTC_989 1501-0895 10.3 µM 0.475698847626726 0.318071875988485 no 1091 0.317144471016474 1564 2830112 SGTC_3280 9140961 49.47 µM 0.475308119264313 0.318214587154616 no 1092 0.317283686402523 1508 4901226 SGTC_3296 9122258 64.045 µM 0.474939946804572 0.318349084611509 no 1093 0.317414888847001 1527 4730474 SGTC_571 k831-0106 44.2 µM 0.474843418265563 0.318384351513701 no 1094 0.317449291686931 1610 4783639 SGTC_1039 k821-0043 94 µM 0.474308718779072 0.318579734884564 no 1095 0.317639887517701 1620 15992768 SGTC_3120 9124077 49.47 µM 0.474267693171845 0.318594728046876 no 1096 0.317654513261558 1531 18774327 YGL155W CDC43 SGTC_1882 5615643 20 µM 0.473574718202402 0.318848026596185 no 1097 0.317901603763981 1463 2253075 SGTC_2483 5729050 27.16 µM 0.472139036919985 0.319373070892827 no 1098 0.318413775178804 1661 2865180 SGTC_1052 3253-3998 198 µM 0.472009015409221 0.319420639088184 no 1099 0.318460176801352 1481 5450317 SGTC_2323 6148992 148.28 µM 0.469574706106819 0.320311775867591 no 1100 0.319329449712372 1478 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42 SGTC_1591 genipin 88.4 µM 0.469534818168566 0.320326386446154 no 1101 0.319343701674753 1568 442424 A DNA cross-linking agent. SGTC_874 0599-0792 117 µM 0.467396307676031 0.32111011009682 no 1102 0.320108181901231 1658 765305 SGTC_620 0109-0052 432 µM 0.467071216153139 0.32122931990853 no 1103 0.320224463464639 1599 493037 SGTC_2851 9015922 71.43 µM 0.466387289281147 0.321480173398356 no 1104 0.320469154015253 1593 2996893 SGTC_471 1-acyl-paf 4 µM 0.465970575350044 0.3216330573692 no 1105 0.320618281274825 1453 16759367 SGTC_893 0958-0369 48.9 µM 0.464945546045609 0.322009248545703 no 1106 0.320985226398544 1647 6819948 SGTC_987 1497-1013 404 µM 0.464681344741613 0.322106241412987 no 1107 0.321079834870038 1544 1676435 SGTC_3063 1327-0034 4 µM 0.464060434987815 0.322334235812047 no 1108 0.321302223634122 1493 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_71 0417-1750 47.813 µM 0.4623493046646 0.322962898536003 no 1109 0.321915423810181 1675 6811472 SGTC_686 1319-0111 510 µM 0.462180158045381 0.323025069873298 no 1110 0.321976065525816 1626 4562600 SGTC_362 0310-0100 9.03 µM 0.46160930844124 0.323234927195429 no 1111 0.322180759052448 1535 790235 SGTC_1428 4049-0204 61.7 µM 0.460495373282051 0.323644597111768 no 1112 0.322580345850761 1627 X1428 SGTC_2375 9072683 200 µM 0.459986512241164 0.323831811190794 no 1113 0.322762950891058 1676 16798029 SGTC_1196 1588-0294 184 µM 0.458663234228379 0.324318864442458 no 1114 0.323238009897231 1498 6144269 SGTC_1247 0448-0043 5.84 µM 0.458581188542575 0.324349072554962 no 1115 0.323267473937216 1549 3089013 YGL099W LSG1 SGTC_625 k213-0058 121 µM 0.457830571445412 0.324625493271856 no 1116 0.323537085104122 1612 3655420 SGTC_2621 lithochol-11-enic acid 100 µM 0.456687215448144 0.325046728868809 no 1117 0.323947940636459 1665 6708711 SGTC_80 0159-0065 512.242 µM 0.455899139761577 0.325337202264066 no 1118 0.32423125407701 1547 1548079 SGTC_81 0411-0046 9.971 µM 0.45444399050289 0.325873828253341 no 1119 0.324754648103759 1487 12925265 SGTC_2448 5185112 27.17 µM 0.454005243147616 0.326035699178745 no 1120 0.324912526517904 1523 5718189 SGTC_1751 st044839 27.194 µM 0.453806299088962 0.326109108168433 no 1121 0.324984124716464 1576 5291326 SGTC_188 3229-0966 278.469 µM 0.45303924888564 0.3263922074804 no 1122 0.325260239757631 1668 5722370 SGTC_29 0299-0004 12.984 µM 0.451834009341869 0.326837233711023 no 1123 0.325694283615788 1501 16871 A napthoquinone isolated from Swertia calycina. SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM 0.450828963829137 0.327208528173472 no 1124 0.32605641224704 1540 442882 SGTC_1476 4112-3294 3.34 µM 0.450407134266013 0.32736441586271 no 1125 0.32620845085699 1635 704369 SGTC_3008 9078912 71.4286 µM 0.448027235900043 0.328244474037434 no 1126 0.327066770265425 1538 16648731 SGTC_2992 9074591 71.4286 µM 0.447634404056284 0.328389830460691 no 1127 0.327208534716044 1560 17741321 SGTC_417 st075190 100 µM 0.447479484420968 0.328447161277851 no 1128 0.327264448691522 1648 222757 SGTC_2426 5582046 32.21 µM 0.447119410219492 0.328580428861808 no 1129 0.32739442253031 1585 2251934 SGTC_3256 9138902 49.47 µM 0.445624106606763 0.329134091005444 no 1130 0.327934397113067 1610 17228773 SGTC_958 1222-0007 33 µM 0.445511247457121 0.329175894301028 no 1131 0.327975166715563 1638 7312461 SGTC_3 0833-0587 95.581 µM 0.443528349133628 0.329910712567391 no 1132 0.328691809324469 1541 5382644 SGTC_2154 5570129 200 µM 0.443457511678749 0.329936975529435 no 1133 0.328717422486508 1558 673366 SGTC_1602 st001878 87.6 µM 0.443406927492296 0.329955730112208 no 1134 0.328735713034199 1603 595405 YLR310C CDC25 SGTC_3252 9135871 49.47 µM 0.443059833330505 0.330084430199916 no 1135 0.328861228583633 1589 17682838 SGTC_3035 9091303 49.47 µM 0.442996928578823 0.330107756994928 no 1136 0.328883978150304 1560 25237002 SGTC_2490 carminic acid 95.39 µM 0.441955877140853 0.330493903073679 no 1137 0.32926056745885 1552 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_579 4491-1009 110 µM 0.439708787758134 0.331328006869305 no 1138 0.330074018526709 1722 1271041 SGTC_1852 st056254 31.4 µM 0.439472135251826 0.331415899429407 no 1139 0.330159734091197 1627 442583 SGTC_2428 5615643 7.78 µM 0.43859767925501 0.331740752234353 no 1140 0.330476539455086 1599 2253075 SGTC_2265 7929201 200 µM 0.437480780763678 0.332155854368339 no 1141 0.330881355664447 1501 1265108 SGTC_1855 st056195 39.6 µM 0.437063696698122 0.332310919066863 no 1142 0.331032577180127 1659 4028379 SGTC_2453 5731132 22.18 µM 0.435456749993705 0.332908622472342 no 1143 0.331615462866572 1697 1362040 SGTC_1003 4049-0218 100 µM 0.43452482278795 0.333255447282254 no 1144 0.331953686614149 1640 295161 SGTC_3139 9095020 49.47 µM 0.433833668492746 0.333512758495266 no 1145 0.332204615288656 1460 25236292 SGTC_2798 7813637 45.45 µM 0.430853401234094 0.334623184137301 no 1146 0.333287483942159 1630 956368 SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM 0.428237229596317 0.335599144462961 no 1147 0.334239206885403 1578 521171 SGTC_1795 st049545 62.3 µM 0.427903398609904 0.33572375979485 no 1148 0.334360726319608 1689 5291882 SGTC_321 4534-3890 65.3 µM 0.427803871304873 0.335760915709034 no 1149 0.334396959095802 1669 699746 SGTC_2937 9044753 11.33 µM 0.426646906988278 0.336192955787114 no 1150 0.334818263465149 1535 6465530 YGL099W LSG1 SGTC_137 0438-0332 85.389 µM 0.426635398191008 0.336197254554678 no 1151 0.334822455397684 1557 2063393 YER012W | YPR107C PRE1 | YTH1 SGTC_3294 9122953 26.2835 µM 0.42657564836585 0.336219572661973 no 1152 0.334844218839801 1541 16459826 SGTC_1675 st018485 24.5 µM 0.426468769180836 0.336259496245674 no 1153 0.334883150194278 1593 3323024 SGTC_3353 9151644 39.2805 µM 0.425877111560933 0.336480537057849 no 1154 0.335098696958666 1586 4909158 SGTC_906 1165-0455 526 µM 0.42505874841493 0.336786367253667 no 1155 0.335396924317906 1546 3252859 SGTC_772 k072-0172 35.3 µM 0.424625356164511 0.336948373853864 no 1156 0.335554902870973 1487 5861980 SGTC_3144 9087057 49.47 µM 0.423442121443253 0.337390833460462 no 1157 0.335986359230745 1751 17249618 SGTC_1426 4048-4480 71.7 µM 0.423078894994294 0.337526703763552 no 1158 0.336118850029476 1664 14224343 SGTC_112 phenothiazine 287.218 µM 0.421744445632682 0.338026056331447 no 1159 0.336605779660957 1735 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.  SGTC_2017 5132927 60.65 µM 0.42144326607746 0.338138797556433 no 1160 0.336715715552299 1542 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis SGTC_418 lividomycin a 100 µM 0.42109315344232 0.338269874257929 no 1161 0.336843530427266 1668 72394 An antibiotic. SGTC_2306 7482397 179.52 µM 0.421055238947108 0.338284070029324 no 1162 0.336857372922506 1720 891448 SGTC_1799 st045822 46.1415 µM 0.420450749054705 0.338510431399623 no 1163 0.337078100632986 1690 3674992 SGTC_229 benomyl 22.8748 µM 0.419094486881288 0.339018518758007 no 1164 0.33757353984755 1577 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C SGTC_217 ketoconazole 989 nM 0.418685662845947 0.339171731256163 no 1165 0.33772293754277 1559 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4 SGTC_1561 5-methoxyflavone 52.9 µM 0.418630447705856 0.339192425937798 no 1166 0.337743116924481 1624 94525 SGTC_1719 st032227 49.2 µM 0.415229819468318 0.340467917195102 no 1167 0.33898683568358 1544 3125804 SGTC_291 SEC14.278 35.5 µM 0.413258170007432 0.341208271675438 no 1168 0.339708736712341 1694 1068044 SGTC_1233 0325-0408 14.2 µM 0.411827947790004 0.341745703179206 no 1169 0.340232767593624 1678 12874 SGTC_415 dibenzyl ketone 100 µM 0.411697188784338 0.341794854234755 no 1170 0.340280692878707 1714 7593 SGTC_318 1488-0629 67.2 µM 0.408711234332771 0.342917974297557 no 1171 0.341375794162082 1580 3662576 SGTC_2781 5567276 71.43 µM 0.405777293090746 0.344022884124099 no 1172 0.342453122133974 1667 2853274 SGTC_1045 1348-1485 165 µM 0.404595532493746 0.344468307334708 no 1173 0.342887421482918 1580 6810614 SGTC_4 0960-0234 25.671 µM 0.404231622092213 0.344605514078862 no 1174 0.343021201124313 1604 6821112 SGTC_507 nimesulide 162 µM 0.403238930262678 0.34497989697138 no 1175 0.343386231517393 1717 4495 A COX2 inhibitor. SGTC_3018 9082602 49.47 µM 0.400546857767672 0.345995945930594 no 1176 0.344376889037768 1627 17332089 SGTC_110 0850-0284 111.64 µM 0.400004984362986 0.346200595604317 no 1177 0.34457642279945 1563 3906265 SGTC_782 0083-0095 30.5 µM 0.398497344312813 0.346770223172446 no 1178 0.34513180774429 1621 3591729 An indicator and reagent. SGTC_771 0250-0039 27.3 µM 0.397823641824208 0.347024878473776 no 1179 0.345380094453431 1633 3005115 SGTC_1516 st013856 110 µM 0.397047225551515 0.347318444644692 no 1180 0.345666317901837 1615 5281404 A mutagen and neurotoxin. SGTC_1443 4112-3303 14 µM 0.396787423755609 0.347416697234424 no 1181 0.345762112739794 1619 704433 SGTC_1713 st033146 12.748 µM 0.39662932128428 0.347476493900145 no 1182 0.345820413554931 1744 674619 SGTC_3245 9134821 49.47 µM 0.39491089337593 0.348126673015211 no 1183 0.346454325159137 1544 17014901 SGTC_107 0358-0022 2.6945 µM 0.393166072190472 0.348787295268205 no 1184 0.347098413282042 1713 521106 YGL093W | YPR107C SPC105 | YTH1 SGTC_2159 5658611 73.75 µM 0.392590690076841 0.349005246476821 no 1185 0.347310908420335 1721 793844 SGTC_1898 st060199 18.6 µM 0.391846699856198 0.349287139254611 no 1186 0.347585743603868 1607 688866 SGTC_203 k066-0004 30.888 µM 0.390903326982498 0.349644696311842 no 1187 0.347934347340328 1716 6795412 SGTC_1015 4130-4525 82 µM 0.390622685308528 0.349751090844083 no 1188 0.348038077434212 1595 1363237 SGTC_1492 4158-0558 28.5 µM 0.390233796687481 0.349898542561117 no 1189 0.348181836297751 1746 3967268 SGTC_3324 9138759 60.749 µM 0.388554629167753 0.350535478445411 no 1190 0.348802817534069 1660 45595710 SGTC_1923 st058458 19.1 µM 0.387930067046172 0.350772492512802 no 1191 0.349033893425589 1761 3534982 SGTC_1301 naphtanilide LB 4.81 µM 0.384587535482161 0.352041929704918 no 1192 0.350271515198702 1746 67238 An a1-adrenergic receptor antagonist or alpha blocker. SGTC_393 acivicin 6.25 µM 0.383905394406024 0.352301198672026 no 1193 0.35052428400714 1647 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1 SGTC_2415 st077333 57.7 µM 0.3837077981796 0.352376314102997 no 1194 0.350597516074359 1885 2766255 SGTC_898 1000-0849 28.3 µM 0.383480011494668 0.352462913463541 no 1195 0.35068194405929 1698 6751807 SGTC_3121 9125696 49.47 µM 0.382883171169512 0.352689854958966 no 1196 0.350903194882307 1713 1235365 SGTC_1707 st032323 6.317 µM 0.381612800464288 0.353173072931755 no 1197 0.351374294078177 1671 3132057 YMR211W DML1 SGTC_2266 7929956 200 µM 0.380287202983216 0.353677550336679 no 1198 0.351866116892525 1620 2967153 SGTC_449 xestospongin c 11.1929 µM 0.377796713819816 0.354626040612468 no 1199 0.352790807555986 1715 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1 SGTC_2805 7950783 58.44 µM 0.377331601162231 0.354803276568239 no 1200 0.352963595271519 1693 1178958 YDL195W SEC31 SGTC_1938 st074717 56.4 µM 0.376370228592853 0.355169717051141 no 1201 0.353320837888673 1610 17250979 SGTC_1843 st055809 45.5 µM 0.376236430669641 0.355220726612529 no 1202 0.353370566974718 1646 16413835 SGTC_2197 6588183 93.1375 µM 0.375319731190165 0.355570281879646 no 1203 0.353711346784913 1670 884136 SGTC_2602 kawain 100 µM 0.37395749875965 0.356089951868198 no 1204 0.35421796843889 1663 5369129 SGTC_1758 st042942 75.2445 µM 0.372048487620061 0.356818659080513 no 1205 0.354928374254918 1704 669317 SGTC_2133 5320837 200 µM 0.37148145629118 0.35703520695158 no 1206 0.355139482584913 1714 2841355 SGTC_859 0439-0102 54.6 µM 0.370807568268847 0.357292623033149 no 1207 0.355390431974608 1779 610143 SGTC_2355 9061122 103.12 µM 0.368060610647069 0.358342594531219 no 1208 0.356414020281754 1788 5302957 SGTC_3328 9140624 29.0385 µM 0.36791746264883 0.358397339543297 no 1209 0.356467389414923 1795 4904392 SGTC_2754 granisetron 64.02 µM 0.367653740114757 0.358498204272361 no 1210 0.356565719091847 1792 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients. SGTC_272 doxorubicin 8.13 µM 0.366316385702991 0.359009847819793 no 1211 0.357064502029255 1677 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_775 4577-0580 57.3 µM 0.364134798015149 0.359845019873864 no 1212 0.357878676447719 1719 2006902 SGTC_2249 haloperidol 116.36 µM 0.363836170058958 0.35995939510175 no 1213 0.357990175629459 1734 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_420 mitomycin C 81.9 mM 0.36272989341485 0.360383210925377 no 1214 0.358403333355399 1666 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_1670 st016595 4.04 µM 0.361177408413714 0.360978258970478 no 1215 0.358983414680544 1700 597879 SGTC_3147 9097027 49.47 µM 0.360583473533311 0.361205995874473 no 1216 0.359205422763757 1762 25236841 SGTC_1384 3089-0840 101 µM 0.359125397869444 0.361765285258622 no 1217 0.359750641240512 1784 1069836 SGTC_1726 st035556 14.5795 µM 0.358941107274929 0.361835996588529 no 1218 0.359819573402208 1781 5919439 SGTC_3129 9127257 49.47 µM 0.358639747812391 0.361951636789271 no 1219 0.359932303895845 1568 837894 SGTC_17 0960-0276 49.807 µM 0.358511892693532 0.362000702245188 no 1220 0.359980134749045 1703 6821114 SGTC_2138 5575593 77.673 µM 0.355956257333672 0.36298192316597 no 1221 0.360936662003171 1662 762213 SGTC_2293 7624732 200 µM 0.354989647634274 0.363353282155501 no 1222 0.361298673408123 1615 894453 SGTC_2497 7-hydroxyflavone 100 µM 0.354667577487201 0.363477045906092 no 1223 0.361419321642866 1771 5281894 SGTC_1931 st074438 57.1 µM 0.354557538428562 0.363519334515936 no 1224 0.361460545692479 1659 2787313 SGTC_382 3229-0966 23.2 µM 0.354256753270365 0.36363493637599 no 1225 0.361573237361969 1779 5722370 SGTC_2833 9001315 45.46 µM 0.352270339489367 0.36439869336912 no 1226 0.36231776496558 1689 2989378 SGTC_1789 tunicamycin 25 nM 0.350629045849058 0.365030161596494 no 1227 0.36293333143978 1797 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_1322 1348-1070 12 µM 0.348595364267387 0.365813104300804 no 1228 0.363696554233041 1767 6758089 SGTC_820 1582-0060 59.9 µM 0.348482572242212 0.365856544258266 no 1229 0.363738899954924 1670 3848840 SGTC_1840 st055363 71 µM 0.347656298069115 0.366174822320062 no 1230 0.364049160348163 1627 676033 SGTC_2791 5663188 71.43 µM 0.347594518931825 0.366198623141133 no 1231 0.364072361582408 1801 54690634 SGTC_1745 st081495 74 µM 0.345011427016792 0.367194236088768 no 1232 0.36504289003986 1741 13842402 YBL026W LSM2 SGTC_1508 1080-0625 72.9 µM 0.342071000801838 0.368328665491305 no 1233 0.366148730239987 1723 767111 SGTC_2190 6049624 200 µM 0.338108203511863 0.36985934630399 no 1234 0.367640824358126 1779 2265554 SGTC_2652 actinonin 100 µM 0.337872882761359 0.369950307097818 no 1235 0.367729491744795 1747 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase. SGTC_1498 4478-3555 97.6 µM 0.33677570746528 0.370374504790946 no 1236 0.368142993527493 1831 3437919 SGTC_3154 9100113 49.47 µM 0.336705218959224 0.370401762952959 no 1237 0.368169564359119 1675 25237525 SGTC_2857 9024691 58.44 µM 0.336437900351565 0.37050514194445 no 1238 0.368270336555786 1715 16478292 SGTC_1138 3761-0006 1.03 µM 0.334378683448134 0.371301807142832 no 1239 0.36904691137657 1762 12061087 SGTC_1190 1486-1332 13 µM 0.333776873061512 0.37153473852652 no 1240 0.369273968106021 1678 4150046 SGTC_2540 epiandrosterone 100 µM 0.332445167415428 0.372050343825132 no 1241 0.369776568679159 1728 441302 A steroid. SGTC_599 1935-0052 86.5 µM 0.332215911591979 0.372139129503598 no 1242 0.369863114862602 1732 9557311 SGTC_2585 alliin 100 µM 0.331805670211916 0.372298023824188 no 1243 0.370018001208586 1816 87310 A garlic compound which reacts with lipids. SGTC_2373 9071805 200 µM 0.331735419251182 0.372325235544011 no 1244 0.370044526524739 1892 10149009 SGTC_3316 9136639 10.545 µM 0.331715331326417 0.372333016721789 no 1245 0.370052111425135 1791 4903665 SGTC_2350 9023895 38.85 µM 0.331298562577623 0.372494466342662 no 1246 0.3702094884787 1793 2997209 SGTC_2136 5328288 199.296 µM 0.331244525841521 0.372515400961116 no 1247 0.370229895013076 1694 262395 SGTC_1422 4031-0024 15.5 µM 0.330977819102137 0.372618732551931 no 1248 0.370330619995874 1816 782427 SGTC_472 calcifediol 10 µM 0.330531304226553 0.372791748672729 no 1249 0.370499271568306 1755 5283731 A vitamin D metabolite. SGTC_1485 3909-9022 254 µM 0.330107993506152 0.37295579732022 no 1250 0.370659181766744 1761 714516 SGTC_2086 5274770 176.623 µM 0.329559505075167 0.373168391249599 no 1251 0.37086641243079 1727 689278 SGTC_920 mycophenolic acid 780.421 nM 0.328962974771851 0.373399650034398 no 1252 0.371091836868187 1696 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_2904 7225135 42.03 µM 0.328470218471421 0.373590712823198 no 1253 0.371278079238105 1823 4446116 SGTC_3012 9080433 71.4286 µM 0.327948955158054 0.373792862828822 no 1254 0.371475128942654 1870 17688859 SGTC_2924 9010168 62.78 µM 0.327734400345955 0.37387607896002 no 1255 0.371556245461253 1723 2993929 SGTC_2064 5220758 200 µM 0.326667926304902 0.374289803292906 no 1256 0.371959530789166 1744 788518 SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM 0.324936133815186 0.374961937329896 no 1257 0.372614704328449 1821 17037758 SGTC_1087 pterostilbene 9.05 µM 0.32451956122194 0.375123672020073 no 1258 0.372772357596061 1848 5281727 Similar to reservatol, lowers cholesterol. SGTC_538 2922-0838 53.3 µM 0.322882161289433 0.375759606579872 no 1259 0.373392243291423 1877 777039 SGTC_3047 9092122 49.47 µM 0.322609806173071 0.375865416851628 no 1260 0.373495383134653 1708 17173831 SGTC_1626 st003712 1.76 µM 0.319477838629807 0.377082858807996 no 1261 0.374682096902466 1786 24207035 SGTC_2905 7799065 20.05 µM 0.318987720456994 0.377273485933985 no 1262 0.374867912209058 1852 1296806 SGTC_2450 5739737 12.93 µM 0.317933052534976 0.377683791061883 no 1263 0.375267860052322 1754 2262825 SGTC_3211 9128781 49.47 µM 0.317578377463407 0.377821803926595 no 1264 0.375402388972234 1675 17194361 SGTC_3085 9117376 49.47 µM 0.316677729228391 0.37817233854237 no 1265 0.375744074601097 1795 16480349 SGTC_2239 6685329 187.64 µM 0.316597337981252 0.37820363190343 no 1266 0.375774577969182 1736 805680 SGTC_2411 st077133 39.94 µM 0.316093656328092 0.378399714856709 no 1267 0.375965710802447 1901 1403142 YNL221C POP1 SGTC_533 1222-0222 6.71 µM 0.314388172237872 0.379063891022465 no 1268 0.376613119136115 1870 3982874 SGTC_2945 9067681 61.76 µM 0.31423772431466 0.379122497968 no 1269 0.376670246438364 1786 16456930 SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM 0.311957615007526 0.380011053333688 no 1270 0.377536367643544 1800 1377 SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM 0.31176219756504 0.380087236785435 no 1271 0.377610627548283 1811 676296 Flavone; oxidizing agent. SGTC_3133 9127736 49.47 µM 0.311662832994676 0.380125975828391 no 1272 0.37764838846942 1936 27243420 SGTC_3274 9138298 49.47 µM 0.310137277586417 0.380720891460857 no 1273 0.378228282732496 1757 17015756 SGTC_762 1165-0429 115 µM 0.309321746597536 0.381039037117486 no 1274 0.378538395090692 1869 5967793 SGTC_2067 5224629 34.075 µM 0.308717792964563 0.381274696478391 no 1275 0.378768103856827 1724 2835000 SGTC_2182 6325192 200 µM 0.308307312132845 0.381434888962256 no 1276 0.378924251297865 1833 736248 SGTC_356 1634-0012 32.5 µM 0.30752062857705 0.381741953452711 no 1277 0.379223561953247 1936 735457 SGTC_2770 toltrazuril 17.5 µM 0.307194919194565 0.381869108689329 no 1278 0.379347506291679 1894 68591 Kills coccidiodes. SGTC_1853 st056710 91.2 µM 0.306774764555825 0.382033153683123 no 1279 0.379507408822071 1919 269167 SGTC_3057 9095946 49.47 µM 0.30669899484348 0.382062739431735 no 1280 0.379536247467689 1792 24540043 SGTC_965 1291-5240 308 µM 0.30656136692959 0.3821164806722 no 1281 0.379588631624762 1853 2834598 SGTC_2422 chlorphenesin carbamate 384.24 µM 0.30592356681872 0.382365559852454 no 1282 0.379831420965201 1747 2724 A muscle relaxant with antifungal properties. SGTC_1967 st070177 51.4 µM 0.304117199813753 0.383071261680665 no 1283 0.380519301756162 1831 5729214 SGTC_191 3914-0123 66.505 µM 0.301963267613731 0.383913255786859 no 1284 0.381340032406503 1746 3144412 SGTC_988 1497-1057 103 µM 0.301727332921213 0.384005518458516 no 1285 0.381429965070469 1951 3533044 SGTC_3218 9131285 49.47 µM 0.301671111663553 0.384027504849212 no 1286 0.381451396214484 1901 17156417 SGTC_3115 9123671 49.47 µM 0.300136862718823 0.384627645890428 no 1287 0.382036381109435 1831 3286988 SGTC_2030 5175110 200 µM 0.299210167572826 0.384990268595504 no 1288 0.382389845934996 1829 2831986 SGTC_1604 st002052 72.4 µM 0.298381752897239 0.385314518605285 no 1289 0.382705907105618 1800 6254834 YHR062C RPP1 SGTC_208 k072-0098 12.366 µM 0.297019795384892 0.385847776955991 no 1290 0.383225698107887 1802 5948901 SGTC_2709 st078560 56 µM 0.296113324786784 0.386202814466091 no 1291 0.383571769181296 1903 17250903 SGTC_2553 4-methylesculetin 85.09 µM 0.295268408580711 0.386533828788052 no 1292 0.383894423765855 1738 5319502 SGTC_860 0443-0016 25.1 µM 0.294587591397151 0.386800613837078 no 1293 0.384154471187093 1827 5337942 SGTC_1904 st060225 78 µM 0.294049393398948 0.387011549995736 no 1294 0.384360080183022 1759 66595 SGTC_330 1488-0319 80.1 µM 0.289483273708074 0.388802487959558 no 1295 0.38610578893816 1820 6846614 SGTC_2250 alverine citrate 130 µM 0.289188908391421 0.388918026437323 no 1296 0.386218409616866 1758 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1 SGTC_2869 9037858 32.47 µM 0.289079087080686 0.38896113385274 no 1297 0.386260428403921 1759 27187042 SGTC_759 3486-0358 89.3 µM 0.288801999884878 0.389069903087855 no 1298 0.386366450803439 1945 875103 SGTC_1838 st055369 84.5 µM 0.285075283870733 0.390533648956562 no 1299 0.387793232668704 1788 676036 SGTC_2441 5730946 39.09 µM 0.284428536394606 0.390787831291937 no 1300 0.388040996387267 1882 1774275 SGTC_1556 plumbagin 1.48 µM 0.284349304678188 0.390818973863394 no 1301 0.388071352551931 1867 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_2541 muurolladie-3-one 83.07 µM 0.283975310414411 0.390965984333614 no 1302 0.388214650757525 1837 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils.  YMR203W TOM40 SGTC_963 1269-2853 151 µM 0.282734586823385 0.391453802120024 no 1303 0.388690150539708 1741 3668223 SGTC_1851 st056236 18.9 µM 0.282096997148386 0.391704551005939 no 1304 0.388934567848224 1922 5393171 SGTC_228 caffeine 993.056 µM 0.281835937191927 0.391807232680277 no 1305 0.389034656771043 1901 2519 Caffeine is a phosphodiesterase inhibitor. SGTC_1600 coumarin 106 71.1 µM 0.281542445321143 0.39192267966989 no 1306 0.38914718870116 1846 100336 A hepatotoxic, DNA x-linker. SGTC_343 4130-2827 29.8 µM 0.281438131027651 0.391963714687441 no 1307 0.389187187581809 1760 1118244 SGTC_385 1494-0393 12.4 µM 0.281377522323448 0.391987557410603 no 1308 0.389210428275968 1848 3090647 SGTC_2883 9059145 45.46 µM 0.280753044051038 0.392233243131398 no 1309 0.389449910487827 1772 16476510 SGTC_1490 4089-0339 670 nM 0.280402731689916 0.392371083789939 no 1310 0.389584270748296 1922 742542 SGTC_195 4234-0266 16.654 µM 0.280110590968849 0.39248604544062 no 1311 0.389696329709607 1818 2303354 SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM 0.279571808339062 0.392698088894046 no 1312 0.389903019301648 1909 23847180 SGTC_1792 st045773 43.6 µM 0.275810482448632 0.394179281491242 no 1313 0.391346816032322 1807 2919270 SGTC_1689 st020265 53.493 µM 0.274580149782936 0.394664114271132 no 1314 0.391819409266844 1936 5758320 YPR016C TIF6 SGTC_2381 9035592 200 µM 0.274351963559374 0.394754052760407 no 1315 0.391907077334324 1751 4749657 SGTC_3225 9130819 49.47 µM 0.273266236195135 0.395182063678286 no 1316 0.392324283763343 1903 4547121 SGTC_2512 diallyl trisulfide 49.23 µM 0.271930890335253 0.395708651576311 no 1317 0.392837579425186 1898 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent SGTC_1539 benzyladenosine 56 µM 0.270982898447811 0.396082603742362 no 1318 0.393202092694165 1824 92208 A nucleotide analog. SGTC_2657 nystatin 74.44 µM 0.270730812346262 0.39618205967639 no 1319 0.393299038337966 1879 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_1372 2752-0194 270 µM 0.270634289980695 0.396220142589496 no 1320 0.393336160037573 1814 823334 SGTC_934 2950-0684 338 µM 0.270482949771086 0.3962798558844 no 1321 0.393394366176487 1942 1121253 SGTC_1282 0886-0010 32.4 µM 0.270220112949768 0.396383567434129 no 1322 0.393495460085517 1962 2836211 YNL267W PIK1 SGTC_2646 retinol 96.75 µM 0.26981125277201 0.396544912227983 no 1323 0.393652732662606 1858 445354 A vitamin A analog and teratogen. SGTC_2243 6634756 200 µM 0.268920284460548 0.396896568328057 no 1324 0.393995513518599 1942 885676 SGTC_816 0325-0417 81.3 µM 0.26875486677406 0.39696186623896 no 1325 0.394059163456743 1799 68101 SGTC_2665 lovastatin 100 µM 0.26847378022114 0.397072830555139 no 1326 0.394167327314172 1827 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1 SGTC_1875 nocodazole 6 µM 0.267267230103909 0.397549233936232 no 1327 0.39463170794002 1973 4122 A microtubule depolymerizer. YJL014W CCT3 SGTC_3032 9089427 49.47 µM 0.266862165053361 0.39770920719369 no 1328 0.394787644203596 1817 17173707 SGTC_3152 9099253 49.47 µM 0.265036379198652 0.398430482083421 no 1329 0.395490718526501 1903 25236131 SGTC_1280 0880-0253 10.1 µM 0.264769276575281 0.39853602987381 no 1330 0.395593603093567 1843 6836607 SGTC_1558 st069300 45.6 µM 0.263699590565351 0.398958799375522 no 1331 0.396005705525742 1963 24208000 SGTC_755 1995-0008 37.3 µM 0.263572857733559 0.399008895561596 no 1332 0.396054537759409 1945 689533 SGTC_158 k038-0087 26.446 µM 0.263100644856604 0.399195571099862 no 1333 0.396236503463501 1832 X158 SGTC_1470 k295-0292 231 µM 0.262421802821948 0.399463971810731 no 1334 0.396498132648009 1930 5045612 SGTC_1447 4239-0816 81.9 µM 0.260227761591842 0.400331776709548 no 1335 0.397344045541803 1764 1341554 SGTC_574 1315-0397 40 µM 0.260093887598706 0.400384743610662 no 1336 0.397395676354863 1874 6794277 SGTC_1267 0828-0272 9.49 µM 0.259067110234982 0.400791046277382 no 1337 0.397791730452221 1956 745334 SGTC_675 1309-0189 238 µM 0.258952867077784 0.400836259702776 no 1338 0.397835803459443 1828 4246530 SGTC_397 arbidol 50 µM 0.258312407091886 0.401089755831672 no 1339 0.398082905822602 1947 131410 A RNA synthesis inhibitor. SGTC_1034 k072-0165 12.7 µM 0.256957675935004 0.401626099887749 no 1340 0.398605722976875 1976 5835461 SGTC_2724 maprotiline 69.64 µM 0.25656530515463 0.401781475877803 no 1341 0.398757180542424 1921 4011 A tricyclic antidepressant. SGTC_265 mycophenolic acid 32.932 µM 0.256235111770031 0.401912242100954 no 1342 0.398884649061622 1952 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1 SGTC_405 ebelactone b 50 µM 0.254253836300345 0.402697115196476 no 1343 0.399649730693165 1846 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).  SGTC_1884 5633444 25 µM 0.251802699440219 0.403668664330117 no 1344 0.400596785343823 1870 5724239 SGTC_2396 5342950 42.78 µM 0.251511895791735 0.403783968804562 no 1345 0.400709183109363 1848 1886677 SGTC_1179 1021-1431 9.29 µM 0.251031985443255 0.403974272905956 no 1346 0.400894689990454 1885 2840958 SGTC_2679 rapamycin 1 nM 0.250410974753127 0.404220562800699 no 1347 0.401134771650967 1879 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2 SGTC_282 k297-0036 65.7 µM 0.249964095781881 0.404397816377905 no 1348 0.401307557395786 1916 5061378 SGTC_3299 9121982 43.1275 µM 0.249945960048566 0.404405010291922 no 1349 0.401314569984469 1835 17594604 YPL160W CDC60 SGTC_2854 9024559 71.43 µM 0.24981290734759 0.404457789388095 no 1350 0.401366018772105 1803 3163529 SGTC_553 k007-0256 45.7 µM 0.249623475426995 0.40453293588721 no 1351 0.401439271213704 1876 6287000 SGTC_3348 9149464 3.537 µM 0.249366176676989 0.404635010387619 no 1352 0.401538772989505 1938 1951442 SGTC_1053 3366-3204 134 µM 0.249160803292382 0.404716489929191 no 1353 0.401618198930857 1787 3632071 YPR165W RHO1 SGTC_1571 st070080 73.4 µM 0.248331396096016 0.405045589751243 no 1354 0.4019390045376 1934 4315245 SGTC_1323 1348-1351 11.2 µM 0.248285305966795 0.405063879788919 no 1355 0.401956833634116 1834 6989654 SGTC_1111 tnp00062 510.699 nM 0.246979080229933 0.405582318018449 no 1356 0.402462207098517 1984 676306 SGTC_674 0498-0004 451 µM 0.246621260979817 0.405724364667692 no 1357 0.402600674408759 1826 4231473 SGTC_2942 9052777 62.25 µM 0.245773339777434 0.406061020926066 no 1358 0.40292884796163 1870 6469503 SGTC_2092 5303694 80.6725 µM 0.243782625427899 0.406851681179396 no 1359 0.403699588664389 1832 1963699 SGTC_2134 5324836 1.464 µM 0.243673456494697 0.406895051270815 no 1360 0.40374186621876 1890 699272 SGTC_2987 9018338 71.43 µM 0.243394127471973 0.40700602691441 no 1361 0.403850046325133 1878 5055682 SGTC_2495 cafestol 54.53 µM 0.241866178354203 0.40761320328128 no 1362 0.404441928951513 1920 16667697 An anti-infammatory. SGTC_1119 parthenolide 318.541 nM 0.239921146955329 0.408386440791333 no 1363 0.405195693341657 1938 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs. SGTC_77 0828-0286 12.516 µM 0.23972523893975 0.408464342873801 no 1364 0.405271633764594 1995 745345 SGTC_3092 9117248 49.47 µM 0.239235574198332 0.408659072022406 no 1365 0.405461459597065 1959 17141857 SGTC_657 3534-0529 86.7 µM 0.238847172540446 0.408813547059175 no 1366 0.405612045104218 1977 1049549 SGTC_708 3448-5400 146 µM 0.238346708665135 0.409012612343901 no 1367 0.405806098358086 1980 3462195 SGTC_876 0720-0963 56.8 µM 0.236918637505864 0.409580773006213 no 1368 0.406359955460747 2018 765861 SGTC_2245 6637752 200 µM 0.236809867011099 0.409624055341437 no 1369 0.406402148245928 2011 681890 SGTC_924 2046-0044 21.3 µM 0.235797728543829 0.410026861759818 no 1370 0.406794815413003 1923 3623589 SGTC_2082 5219693 150 µM 0.235024419720845 0.410334683823015 no 1371 0.407094889901078 1877 2834649 SGTC_3168 9103419 49.47 µM 0.23136747337859 0.411791107345243 no 1372 0.408514666069876 2007 16649256 SGTC_438 sphingosine 6.67 µM 0.230323194919332 0.412207228076625 no 1373 0.408920319062405 1720 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes. SGTC_1519 esterone 74 µM 0.229065852485992 0.412708380808643 no 1374 0.409408866809952 1796 698 A steroid. SGTC_516 3992-2719 87.3 µM 0.227626433844007 0.41328228033759 no 1375 0.409968334061627 1773 5350887 YDR037W KRS1 SGTC_2979 9012552 45.46 µM 0.227290910199535 0.413416081068684 no 1376 0.41009877038548 2059 17100905 SGTC_2160 5660466 132.927 µM 0.224504299180953 0.414527718044608 no 1377 0.411182461014472 2026 2859134 SGTC_1985 st071382 65.5 µM 0.2243472506901 0.41459038841855 no 1378 0.411243556172611 1899 6123237 SGTC_263 alizarin 107.927 µM 0.224136766250165 0.414674385876457 no 1379 0.41132544241177 1932 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. SGTC_113 0099-0221 2.5 µM 0.224105919324266 0.414686696203889 no 1380 0.411337443332536 2006 89219 SGTC_3208 9114115 49.47 µM 0.222470064080776 0.415339649681848 no 1381 0.41197398738655 1780 650895 SGTC_1058 3448-5425 97.3 µM 0.221647868174371 0.415667918540087 no 1382 0.412294007882446 2011 7279705 SGTC_1696 st025591 34.7925 µM 0.221471481302771 0.415738350206849 no 1383 0.412362669945681 1906 2787147 SGTC_270 tamoxifen 5.46 µM 0.220240798992927 0.416229839574417 no 1384 0.412841811803396 2035 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  YIL048W NEO1 SGTC_1059 3448-6867 171 µM 0.219742569001542 0.416428851657618 no 1385 0.413035824787839 2066 3934407 SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM 0.219488104431639 0.416530502792314 no 1386 0.413134922626155 2099 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W SGTC_264 promethazine 12.5 mM 0.219380471193976 0.416573500795256 no 1387 0.413176840623401 2049 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3 SGTC_2322 7413319 38.22 µM 0.218159618366372 0.417061284519213 no 1388 0.413652373572872 1921 1840400 SGTC_361 000s-0510 1.45 µM 0.216913493916448 0.417559297041901 no 1389 0.414137880668365 1905 660 SGTC_2274 7947094 46.08 µM 0.216881148190963 0.417572225746726 no 1390 0.414150484755304 2064 2971028 SGTC_1518 st038567 90.8 µM 0.21309211303439 0.419087329895371 no 1391 0.415627558130951 2027 77966 SGTC_649 1123-0311 367 µM 0.21245471517117 0.41934232185466 no 1392 0.415876151681934 2023 693629 YIL048W NEO1 SGTC_2390 9097792 176.6 µM 0.212381771073755 0.419371505411231 no 1393 0.415904602988102 1847 4497149 SGTC_1554 st069299 38.7 µM 0.212254269513214 0.419422517444155 no 1394 0.415954335088076 1980 24207999 SGTC_570 0987-0065 62.6 µM 0.212091863150637 0.419487496482216 no 1395 0.416017683786838 2050 3104428 SGTC_2660 2',4'-dihydroxychalcone 17.14 µM 0.211709258565024 0.419640585847468 no 1396 0.416166932268552 1997 5357218 A potent inhibitor of glutathione S-transferases. SGTC_765 1319-0117 244 µM 0.211077969510497 0.419893206474585 no 1397 0.416413215363842 1902 3487746 YGL099W LSG1 SGTC_637 1181-0519 7.26 µM 0.210476855332117 0.420133782816222 no 1398 0.416647756921601 1970 6252091 YGR060W ERG25 SGTC_3034 9090421 49.47 µM 0.210338728694302 0.420189067717237 no 1399 0.416701655099722 2037 17173761 SGTC_748 act1.228 77.9 µM 0.210006849463671 0.420321908127937 no 1400 0.416831163571917 1877 4421505 YNR035C ARC35 SGTC_3172 9105863 49.47 µM 0.209754669255971 0.420422853693533 no 1401 0.416929577313008 2025 2348785 SGTC_2899 9053889 58.44 µM 0.209548631821133 0.420505332589854 no 1402 0.417009987625487 2075 6470052 SGTC_1113 artemisinin 1.17947 µM 0.208658392995758 0.420861744389394 no 1403 0.417357461355691 2055 2240 An anti-malaria and mitochondrial poison. SGTC_237 nikkomycin 200 µM 0.208605791272744 0.420882805798799 no 1404 0.41737799462919 2032 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine. SGTC_1073 triclabendazole 3.09 µM 0.205936524957276 0.421951859788017 no 1405 0.418420247052258 1941 50248 An antihelmetic and likely tubulin inhibitor. SGTC_2625 euphol 100 µM 0.205519415262184 0.422118966405932 no 1406 0.418583165329096 2057 6708538 A triterpene alcohol. SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM 0.204229668158305 0.422635766248218 no 1407 0.419087014039937 1957 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_2080 5212524 12.4 µM 0.204058883727519 0.422704209333717 no 1408 0.419153742139398 2094 260183 SGTC_3136 9095672 49.47 µM 0.203366309006727 0.4229817875181 no 1409 0.419424365534657 2097 17217380 SGTC_2031 5180455 200 µM 0.20156519945025 0.423703835940519 no 1410 0.420128326790685 1968 29949 SGTC_2964 9083345 53.42 µM 0.201030873698623 0.423918091664747 no 1411 0.420337216557301 1905 17741579 SGTC_348 k064-0012 10.7 µM 0.200829301390468 0.423998924648276 no 1412 0.420416025240332 1925 5066323 SGTC_2357 9067248 200 µM 0.199600286657377 0.4244918437875 no 1413 0.420896601786937 1953 9150235 SGTC_414 piperonyl butoxide 100 µM 0.199394169079785 0.424574522648948 no 1414 0.420977210654601 1908 5794 A potent inhibitor of cytochrome P450. SGTC_617 3770-0098 35 µM 0.199161957717979 0.424667672348384 no 1415 0.421068028299204 1938 5962639 SGTC_2472 5377652 49.4 µM 0.197852693247386 0.425192951729206 no 1416 0.421580158865451 1916 1610903 SGTC_2139 5578692 56.4705 µM 0.197422145965993 0.425365717180261 no 1417 0.421748600335622 2085 650991 YMR113W FOL3 SGTC_2285 7945142 200 µM 0.195733519711748 0.426043449265278 no 1418 0.422409373453661 1940 2970608 SGTC_2054 5233173 129 µM 0.194326879707043 0.426608172751811 no 1419 0.422959969913073 1974 6889 SGTC_2326 6164455 177.58 µM 0.193352001363488 0.426999645330429 no 1420 0.423341651703345 1933 2888790 SGTC_753 1322-0200 289 µM 0.193186580723161 0.427066078862384 no 1421 0.423406423904801 1980 5403907 SGTC_2546 rhodinyl acetate 100 µM 0.192569363406311 0.427313973829819 no 1422 0.423648120130674 2094 6708682 SGTC_1116 jasmonic acid  1.58368 µM 0.191703746751109 0.427661682552396 no 1423 0.423987135470967 2031 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid. SGTC_566 0958-0068 16.5 µM 0.191112365121917 0.427899266395267 no 1424 0.424218780111259 2040 6815365 SGTC_458 nppb 133 µM 0.186076685358001 0.429923369540216 no 1425 0.426192312494649 2099 4549 A chloride channel blocker. SGTC_2755 lomerizine 42.69 µM 0.184999862607554 0.430356441963783 no 1426 0.426614571668297 1945 3949 A calcium channel blocker. SGTC_1601 4'-hydroxyflavanone 55.5 µM 0.182661908290679 0.431296999174248 no 1427 0.427531652807771 2064 165506 SGTC_823 0417-1665 178 µM 0.182561801231385 0.431337280905149 no 1428 0.427570929376594 1977 3429856 SGTC_2226 7298446 200 µM 0.182059220202917 0.431539523518813 no 1429 0.427768125695083 2087 3283010 SGTC_3081 9117243 49.47 µM 0.181751516192988 0.431663354927565 no 1430 0.427888867569261 2082 45595589 SGTC_1293 1000-1278 195 µM 0.179395117579025 0.43261187814059 no 1431 0.428813732404752 2057 678847 SGTC_796 1234-0020 70.7 µM 0.178231843120042 0.433080275597617 no 1432 0.429270451439751 2095 46495034 SGTC_3351 9150312 21.596 µM 0.176692292327654 0.433700326802588 no 1433 0.429875047724896 2106 4904905 SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM 0.176352002139587 0.433837400115683 no 1434 0.430008705173848 2092 688798 SGTC_134 0269-0018 6.916 µM 0.1752810011797 0.434268865086646 no 1435 0.430429419762065 1955 4378915 SGTC_1194 1488-0194 225 µM 0.175171736319896 0.43431288809457 no 1436 0.430472346039558 1995 1391452 SGTC_3070 9117005 49.47 µM 0.174762530532503 0.434477765073669 no 1437 0.430633115736689 2108 8779016 SGTC_3053 9095903 49.47 µM 0.174532927840749 0.434570281461904 no 1438 0.43072332759976 2130 17174018 SGTC_1992 st073643 23.3 µM 0.174149247444148 0.434724890102388 no 1439 0.4308740853068 1997 3161292 SGTC_960 1222-0186 7.7 µM 0.173316368406328 0.435060543073312 no 1440 0.43120137913133 2034 3126296 SGTC_1813 st051246 8.6015 µM 0.172866923186568 0.435241690421398 no 1441 0.431378015830636 2105 5291959 SGTC_952 1185-0122 232 µM 0.171541328435054 0.435776045838814 no 1442 0.431899068313765 2055 678600 SGTC_92 0063-0024 660.874 µM 0.171361263792712 0.435848640074601 no 1443 0.431969855613515 2136 3594437 SGTC_1981 st071826 47 µM 0.170319036858825 0.436268863052067 no 1444 0.432379620369777 1995 11838600 SGTC_322 k048-0136 19.3 µM 0.169166060343324 0.43673382375256 no 1445 0.432833012462739 2037 6823282 SGTC_2806 7952793 58.44 µM 0.167255156170718 0.437504626049754 no 1446 0.433584643613352 2029 2972490 SGTC_2977 9011197 71.43 µM 0.166601929931702 0.437768172777 no 1447 0.433841637529109 2087 2704722 SGTC_1956 st077085 54 µM 0.166130286543186 0.437958476350527 no 1448 0.434027210055599 1968 24208685 SGTC_612 0302-0167 22.4 µM 0.165886209532061 0.438056964715561 no 1449 0.434123250163037 2075 235821 SGTC_467 ro 31-8220 72.8 µM 0.165323799963159 0.438283919156941 no 1450 0.434344563453138 2110 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7 SGTC_1779 st039427 55 µM 0.164753843438443 0.438513939801795 no 1451 0.434568867533475 2163 1124498 SGTC_2119 5528445 120.635 µM 0.164441307034526 0.438640080745126 no 1452 0.434691873915065 2084 791935 SGTC_1393 3470-5649 58.2 µM 0.16257334728368 0.439394126293983 no 1453 0.435427186779234 2026 4108395 SGTC_1038 k292-0204 154 µM 0.161661264347358 0.439762389947315 no 1454 0.43578630489495 1999 4454212 SGTC_3230 9131665 49.47 µM 0.161536182576894 0.439812897178185 no 1455 0.435835557983611 2060 15943720 SGTC_982 1491-0518 27.5 µM 0.161047963565059 0.440010046305388 no 1456 0.436027812094391 2008 3091256 SGTC_1586 deoxycorticosterone acetate 53.7 µM 0.160066203937541 0.440406538475982 no 1457 0.436414461610282 2100 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE. SGTC_2636 apigenin dimethyl ether 100 µM 0.1599139178513 0.440468045901157 no 1458 0.436474442376885 2044 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_369 0957-0393 4.5 µM 0.159100942858463 0.4407964258296 no 1459 0.436794672694594 1964 6997992 SGTC_244 nsc-207895 1.295 µM 0.159089853435787 0.440800905393057 no 1460 0.436799041097768 2019 42640 SGTC_2593 nobiletin 86.24 µM 0.159020391693567 0.440828964580803 no 1461 0.436826404004572 1975 72344 An anti-infammatory. SGTC_3221 9128209 49.47 µM 0.157881741344827 0.441288966553315 no 1462 0.437274992949952 2029 16460723 SGTC_2189 6047310 154.431 µM 0.157878221403966 0.441290388693085 no 1463 0.437276379810524 2042 711535 SGTC_1238 0333-0287 48.8 µM 0.157686592253326 0.441367812566506 no 1464 0.437351883069345 2032 7226 SGTC_1708 st033234 31.827 µM 0.157570286325409 0.441414804711655 no 1465 0.437397709551314 2088 674664 SGTC_1494 4358-1428 177 µM 0.157270196908629 0.441536056384147 no 1466 0.437515953681022 2158 1564571 SGTC_1472 k841-0093 193 µM 0.156726444683199 0.441755774407175 no 1467 0.437730222393593 2101 X1472 SGTC_1860 st056228 74.6 µM 0.155851756612734 0.442109253725461 no 1468 0.438074936579181 2005 688679 SGTC_2961 9083290 32.55 µM 0.155565450164294 0.442224966038412 no 1469 0.438187780046578 2140 17741490 SGTC_1871 st057448 67.3 µM 0.154467431117754 0.442668782045816 no 1470 0.438620594593358 2100 691747 SGTC_2702 st077768 96.8 µM 0.154261494354352 0.442752029098208 no 1471 0.438701778450138 2008 6484119 SGTC_2145 5634607 200 µM 0.152802904396143 0.44334171579704 no 1472 0.439276853629003 2018 308662 SGTC_2844 9010103 25.97 µM 0.152492341421392 0.443467288138903 no 1473 0.439399315229134 2014 2480525 SGTC_1097 itavastatin 7.23 µM 0.152208068251934 0.443582235496437 no 1474 0.439511415283068 2072 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49 SGTC_2927 9011802 47.9 µM 0.152122806710446 0.443616712376938 no 1475 0.439545038197018 1975 43912568 SGTC_848 0368-0089 85.6 µM 0.152009539452749 0.443662514480872 no 1476 0.439589705847841 2133 762535 SGTC_2943 9068529 45.32 µM 0.150067744931999 0.444447838293594 no 1477 0.440355583790111 2134 3270634 SGTC_2510 benzyl isothiocyanate 8.31 µM 0.14944973637207 0.444697826630205 no 1478 0.440599384205149 2118 2346 DNA damaging agent; causes G2/M arrest. SGTC_1502 4534-4282 27.7 µM 0.149356078906927 0.44473571358393 no 1479 0.440636333441902 2039 3278949 SGTC_873 0591-4978 488 µM 0.149069912912643 0.444851478521655 no 1480 0.440749233303631 2158 3305145 SGTC_717 1532-0246 73.2 µM 0.148868421096696 0.444932992383258 no 1481 0.440828729909215 2028 9561992 SGTC_363 0455-0021 3.06 µM 0.148857255973954 0.444937509321041 no 1482 0.440833135067859 2072 4597466 SGTC_2258 7960471 200 µM 0.148495003834202 0.445084065134843 no 1483 0.440976064303721 1987 2974708 SGTC_903 1134-0042 114 µM 0.148438476711559 0.445106934907009 no 1484 0.440998368188083 2006 701009 SGTC_3304 9125678 46.087 µM 0.147950216405814 0.445304483107618 no 1485 0.441191028645578 2039 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2 SGTC_1645 Cervolide 78 µM 0.147687990814191 0.445410584160586 no 1486 0.441294504820303 2051 23173 A fragrance. SGTC_1258 0671-0043 57.1 µM 0.147458366722244 0.445503497288999 no 1487 0.441385119491359 2005 4298767 SGTC_706 4262-0057 46.9 µM 0.146563534838301 0.445865602922701 no 1488 0.44173826888745 2093 883298 SGTC_3066 9117245 49.47 µM 0.146531684369977 0.445878492472754 no 1489 0.441750839672209 2084 17176980 SGTC_273 hydroxyurea 18.1 mM 0.145333358338114 0.446363483873532 no 1490 0.442223839084648 2047 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12 SGTC_1377 2944-0135 198 µM 0.143283531942423 0.447193283626806 no 1491 0.443033130618373 2062 1894137 SGTC_578 3460-0051 92 µM 0.142886925751877 0.44735386243142 no 1492 0.443189742177518 2157 2876744 SGTC_1553 gossypol 38.6 µM 0.142167962486788 0.447644979876364 no 1493 0.443473668470941 2142 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_680 0417-1641 114 µM 0.14141833513169 0.447948543637591 no 1494 0.443769735245472 2045 2835990 SGTC_220 paclitaxel 373.376 µM 0.141016823223991 0.448111149592439 no 1495 0.443928326069087 2153 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_870 0573-2213 57.6 µM 0.140556328079334 0.448297653555725 no 1496 0.444110225387813 2157 3916321 SGTC_1326 1431-2094 10.8 µM 0.140374990500891 0.448371099764086 no 1497 0.444181858435918 2027 616278 SGTC_3300 9124615 50.48 µM 0.139480553373835 0.448733394786798 no 1498 0.444535210940616 2127 24824903 SGTC_2768 sulfasalazine 50.2 µM 0.139405765376357 0.448763689879237 no 1499 0.444564758367985 2159 5384001 An antioxidant and salicylic acid derivative. SGTC_3030 9087619 49.47 µM 0.139258063434075 0.448823521801059 no 1500 0.444623113722171 2077 25236973 SGTC_2569 tetrandrine 100 µM 0.139075790194167 0.448897359660097 no 1501 0.444695129456543 1953 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_214 4373-3496 70 µM 0.139014550267489 0.448922168005547 no 1502 0.444719325619387 2112 3779166 SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM 0.138525296048462 0.449120372461162 no 1503 0.44491263949007 2127 616764 SGTC_1757 st041620 31.8375 µM 0.136268929985407 0.450034624819153 no 1504 0.445804342507268 2031 5289815 SGTC_1085 doxorubicin 7.67 µM 0.135521795688698 0.450337413334015 no 1505 0.44609966637756 2173 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_2055 5235184 200 µM 0.134364128889155 0.450806633964765 no 1506 0.44655732268835 2091 2836034 SGTC_2878 9043973 25.97 µM 0.134208347567855 0.450869779856802 no 1507 0.446618912613611 2147 6465167 SGTC_1652 st011932 78 µM 0.134150810899334 0.45089310263534 no 1508 0.446641660718603 2150 1551076 SGTC_1815 st051655 58.2 µM 0.132116927959106 0.451717655676992 no 1509 0.447445903352686 2183 5984156 SGTC_2005 4024620 188 µM 0.131683426705021 0.451893427741703 no 1510 0.447617347461927 2143 236743 SGTC_43 0570-0105 72.5 µM 0.131576109530988 0.45193694317091 no 1511 0.44765979152141 2110 1114046 YDL195W SEC31 SGTC_20 0481-0013 4.944 µM 0.131049615168236 0.452150436724841 no 1512 0.447868029290202 2086 182045 SGTC_3084 9116877 49.47 µM 0.130916710088279 0.45220433194717 no 1513 0.447920597857462 2190 27241325 SGTC_305 1682-2595 20.8 µM 0.130858108433021 0.452228096173739 no 1514 0.447943777134598 2102 226033 SGTC_1794 st048918 76.9 µM 0.129381659204479 0.452826884216047 no 1515 0.448527829765197 2180 672303 SGTC_743 1275-0778 158 µM 0.128858773866983 0.453038971139885 no 1516 0.448734699157794 2160 2849257 YMR203W TOM40 SGTC_628 1636-0253 16 µM 0.127856664911094 0.453445472796998 no 1517 0.449131202943059 2156 4456143 SGTC_1559 coumarin 343 70.1 µM 0.127276292588658 0.453680920940406 no 1518 0.449360861732343 2146 108770 A hepatotoxic, DNA x-linker. SGTC_1005 4092-0690 4.4 µM 0.127251445751351 0.453691001284956 no 1519 0.449370694238915 2051 1529343 SGTC_90 0870-0863 4.608 µM 0.127156669281875 0.453729452306344 no 1520 0.449408199911725 2101 1738164 SGTC_2309 7664088 163.95 µM 0.126388609538745 0.454041071795881 no 1521 0.449712159060156 2215 704922 SGTC_2016 5121758 140 µM 0.12618510597353 0.454123642618618 no 1522 0.449792700417159 2189 2795203 SGTC_2100 5377183 190 µM 0.124046756600466 0.454991389208776 no 1523 0.450639127256435 2143 2844202 SGTC_913 3487-1245 167 µM 0.1238115089921 0.455086866364682 no 1524 0.45073225953769 2083 4016153 SGTC_2515 chrysin 20.77 µM 0.123367660079113 0.45526701311828 no 1525 0.450907982466151 2147 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor. SGTC_1763 st044482 94.5 µM 0.122647222936281 0.455559439422853 no 1526 0.451193229103648 2142 88505 SGTC_127 0180-0333 59.125 µM 0.12256079653376 0.455594521624453 no 1527 0.451227450080311 2198 771601 SGTC_2001 4023502 57.655 µM 0.121057860699846 0.456204648401715 no 1528 0.45182260296086 2121 108941 YCR052W RSC6 SGTC_541 4513-1321 94 µM 0.120983822193596 0.456234707505725 no 1529 0.451851924540667 2008 747515 SGTC_3181 9108277 49.47 µM 0.120903285314177 0.456267405187175 no 1530 0.451883819979104 2127 17097298 SGTC_2678 equilin 100 µM 0.11982963257758 0.456703332514943 no 1531 0.452309053833624 2205 3247 Equilin is an estrone commonly used hormone replacement therapy SGTC_2966 9084041 48.03 µM 0.119375489960049 0.456887740416773 no 1532 0.45248893930104 1989 17741380 SGTC_3349 9149703 23.001 µM 0.118669710422312 0.457174345725996 no 1533 0.452768517259791 2195 4910494 SGTC_143 4032-1194 15.74 µM 0.118315953946165 0.457318008726069 no 1534 0.452908658383577 2062 1806963 SGTC_165 k038-0023 64.381 µM 0.117525193102312 0.457639162423481 no 1535 0.453221940584815 2141 46368543 SGTC_1674 st016616 23.6 µM 0.117149432005082 0.457791780934547 no 1536 0.453370819153779 2162 625830 SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM 0.116253400688686 0.458155736618884 no 1537 0.453725857992099 2210 756377 SGTC_1387 3342-1166 1.8 µM 0.115575442676642 0.458431137238737 no 1538 0.453994513180058 2121 3418228 SGTC_1624 st003710 6.25 µM 0.113955029155369 0.459089463455612 no 1539 0.454636721338095 2181 24207033 SGTC_3193 9111931 49.47 µM 0.113567138974664 0.459247068506961 no 1540 0.454790469035236 2122 17087244 SGTC_1305 1181-0477 144 µM 0.112861089067094 0.459533962601737 no 1541 0.455070342797958 2200 6252086 SGTC_3116 9124943 49.47 µM 0.112249020239105 0.459782685778594 no 1542 0.45531298110144 2009 41905195 YPL160W CDC60 SGTC_1407 3909-7909 12.3 µM 0.112220175305279 0.459794407731129 no 1543 0.455324416315396 2144 4411780 SGTC_567 1080-0542 68.4 µM 0.11154681126978 0.460068058110517 no 1544 0.455591373580037 2209 5950415 SGTC_1304 1165-0502 251 µM 0.110798931393301 0.460372013366756 no 1545 0.45588789637993 2152 767425 SGTC_2800 7887935 81.82 µM 0.109187214085027 0.461027130143777 no 1546 0.456527000678404 2122 2961002 SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM 0.107725259801013 0.46162146409845 no 1547 0.457106815843255 2194 6708784 An antioxidant flavonoid SGTC_28 pentachloropyridine N-oxide 1.606 µM 0.107686606967069 0.461637178954142 no 1548 0.457122146910036 2193 140250 A respiratory chain inhibitor. SGTC_1808 st050063 61.5 µM 0.105841771071426 0.462387292258743 no 1549 0.457853947191821 2218 4011993 SGTC_972 1319-0219 195 µM 0.104893537685738 0.462772897734562 no 1550 0.458230143430207 2110 23903702 SGTC_2171 5739187 198.077 µM 0.104477756192304 0.462941989126636 no 1551 0.458395109824702 2176 2262761 SGTC_1118 chelidonine 707.474 nM 0.104366353793749 0.462987295760996 no 1552 0.458439311307756 2232 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor. SGTC_798 1287-0182 476 µM 0.104200493434073 0.463054750985005 no 1553 0.458505121200785 2216 1649755 SGTC_2926 9010726 65.15 µM 0.104200330074766 0.463054817423578 no 1554 0.458505186018874 2103 2994293 SGTC_1208 2323-2347 50.3 µM 0.103886788937841 0.463182337158349 no 1555 0.458629595637982 2239 5412760 SGTC_1145 3546-0597 10.2 µM 0.103515284511583 0.463333435931194 no 1556 0.458777009686975 2129 875334 SGTC_40 0327-0103 19.753 µM 0.103341540231017 0.463404103252142 no 1557 0.45884595387538 2156 409036 SGTC_949 1165-0505 146 µM 0.10320935084682 0.463457869649655 no 1558 0.458898409322361 2126 6244267 SGTC_9 0092-0002 10.449 µM 0.102728172340815 0.463653588686893 no 1559 0.459089356816399 2227 759368 SGTC_1625 st003711 30.1 µM 0.102581550235972 0.463713228881376 no 1560 0.459147543179546 2191 24207034 YER133W GLC7 SGTC_1330 1469-0054 61.8 µM 0.102280257394274 0.463835785700283 no 1561 0.459267112717038 2238 7102664 SGTC_118 0083-0097 135.343 µM 0.101555350305606 0.464130670027072 no 1562 0.459554810717035 2215 5207356 SGTC_3286 9117135 37.221 µM 0.101376606330379 0.464203384168616 no 1563 0.459625753116248 2113 3438150 SGTC_1650 st011916 45.8 µM 0.0999990759685865 0.464763811871799 no 1564 0.460172529519612 2222 242528 SGTC_2616 abietic acid 100 µM 0.0991811650578256 0.465096599886938 no 1565 0.460497214610918 2263 6708678 Abietic acid is an inhibitor of 5α-reductase. SGTC_1796 st049173 110.4 µM 0.0966884470163994 0.466110975713078 no 1566 0.461486907393433 2238 94134 SGTC_12 0849-0099 9.267 µM 0.0954973081768129 0.466595770721715 no 1567 0.461959914126962 2245 6071388 SGTC_679 0422-0091 41.4 µM 0.0948220096175344 0.466870640147802 no 1568 0.462228102245939 2199 627384 YHR062C RPP1 SGTC_325 2810-4341 181 µM 0.0940624463718635 0.467179827034776 no 1569 0.462529775764157 2248 774970 SGTC_1613 st002381 52.1 µM 0.0940070930908433 0.467202359850177 no 1570 0.462551761109988 2262 551167 SGTC_2033 5192550 145 µM 0.0927427532651814 0.467717066685495 no 1571 0.463053965581544 2173 182073 SGTC_62 0180-0423 3.232 µM 0.092546480464052 0.467796973287489 no 1572 0.463131931788347 2195 30102 YGL099W LSG1 SGTC_69 0096-0274 206.684 µM 0.092324920126144 0.467887176512901 no 1573 0.463219944763077 2188 6741392 SGTC_2141 5621638 7.665 µM 0.090467966359094 0.468643257155372 no 1574 0.463957674342467 2229 2856238 SGTC_2102 5377816 72.7585 µM 0.0903788332395456 0.468679551623589 no 1575 0.463993088237153 2226 1379702 SGTC_2002 4023503 131 µM 0.089641523115629 0.46897978980966 no 1576 0.464286043269555 2278 4736863 YCR052W RSC6 SGTC_2720 fluspirilene 36.88 µM 0.0892712196898423 0.469130586794447 no 1577 0.46443318304365 2218 3396 An atypical antipsychotic. SGTC_1281 0884-0031 11.8 µM 0.0890786074584059 0.469209025152089 no 1578 0.46450971928616 2204 1548255 SGTC_3185 9108267 49.47 µM 0.0884326832847833 0.469472076506144 no 1579 0.4647663927699 2131 4910486 SGTC_168 3970-0862 530.542 µM 0.0877563471468628 0.469747527352362 no 1580 0.465035166889827 2173 3135186 SGTC_1946 st076057 65.1 µM 0.0876777014992099 0.469779558240872 no 1581 0.465066421491478 2253 953009 SGTC_1867 st057372 64 µM 0.0870108200832515 0.470051174299011 no 1582 0.46533145577288 2251 688837 SGTC_74 000s-0487 160.283 µM 0.0866822946682667 0.470184985495565 no 1583 0.465462025122689 2271 677548 SGTC_951 1171-0579 82.7 µM 0.0843688176713428 0.471127378837314 no 1584 0.466381599381121 2243 1616050 YPR165W | YDR526C RHO1 | YDR526C SGTC_189 3970-0742 2.116 µM 0.082396857402965 0.471930783428077 no 1585 0.467165567491649 2273 2891807 SGTC_1392 3455-1037 33.9 µM 0.0817252695260046 0.472204424096855 no 1586 0.467432591697556 2233 981132 SGTC_2608 thymoquinone 42.66 µM 0.0789960466185742 0.473316588509459 no 1587 0.46851788378973 2277 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC). SGTC_850 0388-0143 75.9 µM 0.0778766423716484 0.4737728088866 no 1588 0.468963089829272 2152 67273 SGTC_2809 7964133 12.99 µM 0.0773287846745737 0.47399610437846 no 1589 0.469180996300605 2196 1253665 SGTC_1926 methyl fluorone black 53.6 µM 0.0765042946925055 0.474332164858583 no 1590 0.46950894866037 2267 72721 Reacts with homocysteine. SGTC_1991 st073000 8.92 µM 0.0761871772469937 0.474461426176607 no 1591 0.469635092056297 2244 4301969 YIL048W NEO1 SGTC_1892 st058411 7.36 µM 0.0751542006349072 0.474882499849905 no 1592 0.470046011923058 2262 3934738 SGTC_1807 st050092 58.9 µM 0.0749775548323009 0.474954509042968 no 1593 0.470116285132345 2209 5008496 SGTC_1468 k284-1086 134 µM 0.0746629940755797 0.47508274092554 no 1594 0.470241425953015 2173 15996457 SGTC_1022 4477-0945 21.3 µM 0.0744119697567243 0.475185073791243 no 1595 0.470341292360569 2248 4648966 SGTC_2772 vinpocetine 57.06 µM 0.0721544589619213 0.476105446020249 no 1596 0.471239493570635 2247 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor. SGTC_3163 9099914 49.47 µM 0.0701380128716006 0.47692764571369 no 1597 0.472041905645095 2276 16268368 SGTC_2015 5119600 184 µM 0.0690217247689154 0.477382851220874 no 1598 0.472486163435164 2263 2828786 SGTC_526 4469-0568 170 µM 0.0682549952842535 0.477695529110833 no 1599 0.472791324548197 2271 2901964 SGTC_2792 7535235 81.82 µM 0.0681132002818977 0.477753355659716 no 1600 0.472847761228072 2207 1281891 SGTC_1944 st076371 56.9 µM 0.0679723712927548 0.477810788714672 no 1601 0.472903813958751 2173 24208455 SGTC_1574 spiramycin 23.7 µM 0.0672876036966795 0.478090058040722 no 1602 0.473176372669895 2280 6419898 An antibiotic and protein synthesis inhibitor. SGTC_1748 st037455 53.6035 µM 0.0651112543756952 0.478977711130026 no 1603 0.474042709876408 2251 580690 SGTC_1242 0402-0103 60.1 µM 0.0649897418060622 0.479027274766224 no 1604 0.474091083920642 2278 432868 SGTC_2788 5282734 71.43 µM 0.0648003750702997 0.479104516014225 no 1605 0.47416647140843 2256 743706 SGTC_2802 7925815 54.55 µM 0.0646699201993259 0.479157728018352 no 1606 0.474218406437534 2248 1262923 SGTC_1849 st056239 19.2 µM 0.0643362803593535 0.479293820021498 no 1607 0.474351232865756 2163 5393181 SGTC_2954 9074818 52.69 µM 0.0642237161009722 0.479339735633291 no 1608 0.474396046828147 2261 16648742 SGTC_1581 himbacine 57.9 µM 0.0638878995861511 0.479476718757899 no 1609 0.474529743663333 2170 5281825 An alkaloid muscarinic receptor antagonist. SGTC_3058 9093861 49.47 µM 0.063324226628685 0.479706652387431 no 1610 0.474754162207391 2263 17217477 SGTC_427 1354-0053 47.3 µM 0.0627372103925171 0.479946115390934 no 1611 0.474987883067035 2228 6813657 SGTC_735 3076-0345 636 µM 0.0623227402408207 0.480115195602338 no 1612 0.475152909790695 2286 2888990 SGTC_1971 st069429 63.5 µM 0.0606941974363737 0.480779582655959 no 1613 0.475801376469051 2304 1246522 YGL099W LSG1 SGTC_2547 epiafzelechin trimethyl ether 100 µM 0.0596816165411506 0.481192706380809 no 1614 0.476204606753614 2319 6708630 An antioxidant. SGTC_2364 9055074 200 µM 0.059222021343472 0.481380223700491 no 1615 0.476387634963921 2237 6470630 SGTC_2434 5670830 169.91 µM 0.0581351369933994 0.481823694694623 no 1616 0.476820493218466 2237 1549830 SGTC_2645 abamectin 100 µM 0.0578746681725295 0.481929974650406 no 1617 0.476924230580927 2297 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels. SGTC_3307 9126885 69.2785 µM 0.0574304177045285 0.482111246599431 no 1618 0.477101166578446 2281 24824909 SGTC_1386 3228-0095 33.8 µM 0.0573914138548395 0.482127161906361 no 1619 0.47711670124085 2280 870181 SGTC_1920 st075728 45.7 µM 0.0569730523884733 0.482297873794091 no 1620 0.477283330671143 2307 3400306 SGTC_2365 9042475 200 µM 0.0566796095603649 0.482417614721906 no 1621 0.477400208556409 2243 6464479 SGTC_2718 lomofungin 53.02 µM 0.0566287600179567 0.482438364313323 no 1622 0.477420462058917 2269 5351222 A RNA synthesis inhibitor. SGTC_2967 9089538 49.85 µM 0.0558713852925576 0.482747423158558 no 1623 0.477722133219635 2316 728216 SGTC_1278 0874-0585 172 µM 0.0537130244279121 0.483628233003051 no 1624 0.478581902895017 2267 766306 SGTC_294 k038-0071 157 µM 0.0530240577517405 0.483909411834443 no 1625 0.478856369679749 2258 24152826 SGTC_1225 1216-0074 20.6 µM 0.0524750102063809 0.484133493062983 no 1626 0.479075103430223 2251 4241466 SGTC_1327 1436-0082 2.18 µM 0.0523007114024652 0.484204630194281 no 1627 0.479144543238672 2164 15992205 SGTC_804 1595-0054 20.9 µM 0.0515398513135243 0.484515168326702 no 1628 0.479447673638168 2202 761523 Stimulates phospholipase C. SGTC_3313 9133968 57.047 µM 0.050376308449152 0.484990075874808 no 1629 0.479911257764342 2321 1494643 SGTC_1044 1222-0021 1.78 µM 0.0499914641880644 0.485147157268634 no 1630 0.480064595204671 2247 4306703 SGTC_2794 7785382 27.27 µM 0.0481990783894594 0.485878783080665 no 1631 0.480778792337185 2338 2205081 SGTC_741 4582-0002 126 µM 0.048084715667993 0.485925465919446 no 1632 0.480824363622477 2299 2912688 SGTC_3237 9133362 49.47 µM 0.0474642967593879 0.486178724132162 no 1633 0.481071592653474 2324 43845137 SGTC_525 k781-2675 26.7 µM 0.0465032923876474 0.486571022063432 no 1634 0.481454554990669 2330 3651118 YDL195W SEC31 SGTC_1363 1636-0063 10.4 µM 0.0456764874250922 0.486908547983308 no 1635 0.481784052280664 2320 6072185 SGTC_2103 5378138 10 µM 0.0452497396189029 0.487082762578972 no 1636 0.481954124171137 2327 244142 SGTC_2855 9016525 58.44 µM 0.043727490028211 0.487704222286912 no 1637 0.482560813147903 2323 43811474 SGTC_475 α-linolenic acid 10 µM 0.0436740752555988 0.487726029464924 no 1638 0.482582102220892 2322 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_3222 9128301 49.47 µM 0.0435602792868556 0.487772488063511 no 1639 0.482627457080751 2307 4911358 SGTC_1350 1495-0454 146 µM 0.0424138645765474 0.488240535065791 no 1640 0.483084387980829 2316 1069057 SGTC_1389 3405-0187 19 µM 0.0419126454258513 0.488445173052289 no 1641 0.48328416783243 2291 799890 SGTC_1785 bathophenanthroline 24 µM 0.0397310098614023 0.489335926965011 no 1642 0.484153789447128 2277 72812 An iron chelator. SGTC_3346 9158254 43.5805 µM 0.0376268545366392 0.490195096418324 no 1643 0.484992598127375 2293 17639500 SGTC_421 streptovitacin 30 mM 0.0374634609485164 0.490261815301459 no 1644 0.485057736810758 2239 91467 include heat shock SGTC_2003 4023581 200 µM 0.0373264686163407 0.490317753908536 no 1645 0.485112350645219 2292 16641307 SGTC_2692 st077426 47.7 µM 0.0362737811842184 0.490747608098011 no 1646 0.485532027880564 2334 25238571 SGTC_1575 cyproterone acetate 48 µM 0.0344397537783583 0.491496539881376 no 1647 0.486263241665347 2309 9880 An androgen receptor antagonist and liver toxin. SGTC_289 k017-0060 526 µM 0.033426973805721 0.491910125295744 no 1648 0.486667049845845 2343 5512909 SGTC_799 1310-0557 151 µM 0.0326684046235409 0.492219905259942 no 1649 0.48696950994701 2264 5354492 SGTC_2732 terfenadine 20 µM 0.0311761955931763 0.492829298213666 no 1650 0.487564511924599 2358 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.  SGTC_379 3970-0972 5.9 µM 0.0301642724157318 0.493242560150033 no 1651 0.487968021019665 2313 2898042 YBL034C STU1 SGTC_329 k048-0121 21.3 µM 0.0300527303889619 0.493288113540074 no 1652 0.488012499685152 2266 6832902 SGTC_1396 3511-0007 98.6 µM 0.028269396892906 0.494016432448829 no 1653 0.488723644291122 2336 X1396 SGTC_430 0958-0115 16.4 µM 0.0281695236285703 0.494057221610904 no 1654 0.488763472097577 2237 6833180 SGTC_1352 1496-0991 99 µM 0.0276357124708116 0.494275236053026 no 1655 0.488976349051174 2337 3000039 SGTC_975 1335-0046 28.5 µM 0.0274487060952259 0.494351611954365 no 1656 0.489050925509771 2327 16486740 SGTC_3131 9127911 49.47 µM 0.0271549001468151 0.494471606644708 no 1657 0.489168093448452 2318 45595681 SGTC_563 tetrahydrosecaminediol 614 µM 0.0264455247170122 0.494761328092121 no 1658 0.48945099167988 2356 334274 A psychoactive constituent of the cannabis plant. SGTC_317 4495-0002 170 µM 0.0263997042618672 0.494780042071469 no 1659 0.489469265016823 2283 15991618 SGTC_1682 st012968 530 nM 0.0257494707712191 0.49504561149712 no 1660 0.489728582475913 2335 24207270 SGTC_1560 lithocholic acid 53.1 µM 0.0254325776761516 0.495175038296344 no 1661 0.489854963139217 2345 9903 A bile acid which acts as a detergent. SGTC_2109 5483026 200 µM 0.0251305212079729 0.495298405931523 no 1662 0.489975427730954 2333 759335 SGTC_1358 1509-0022 2.48 µM 0.0249356238319516 0.495378007275075 no 1663 0.490053156176201 2347 3258434 SGTC_3083 9117465 49.47 µM 0.0245046702849025 0.495554020972672 no 1664 0.49022502924307 2236 16420915 SGTC_407 eburnamonine 100 µM 0.0244263821257367 0.495585996179592 no 1665 0.490256252353927 2359 3195 SGTC_1864 st057645 30.4 µM 0.0236436767174981 0.495905677815409 no 1666 0.490568416447494 2369 688666 SGTC_1460 k062-0059 9.15 µM 0.0229462336067418 0.496190537854674 no 1667 0.490846580503124 2335 1373085 SGTC_1672 st016598 6.51 µM 0.0228577408040397 0.496226681536961 no 1668 0.490881874766469 2270 4665860 YNL267W PIK1 SGTC_3234 9132280 49.47 µM 0.0227720626258256 0.496261675653652 no 1669 0.490916046519563 2296 17612295 SGTC_1084 voriconazole 435 nM 0.0226847486518706 0.496297337919034 no 1670 0.49095087075951 2360 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_2865 9030313 51.95 µM 0.0223480346715308 0.496434864671638 no 1671 0.491085166154651 2367 42562754 SGTC_411 enrofloxacin 100 µM 0.0207883390989826 0.497071908731916 no 1672 0.491707249890691 2371 71188 A bacterial gyrase inhibitor. SGTC_2874 9043904 71.43 µM 0.0205804347747762 0.4971568260402 no 1673 0.491790173974568 2277 4463428 SGTC_1450 4112-4260 37.6 µM 0.0201583431289004 0.497329227302619 no 1674 0.491958529247128 2368 1633175 SGTC_2075 5212009 200 µM 0.0188343763179299 0.497869998139767 no 1675 0.492486615172918 2361 780898 SGTC_1239 0337-0584 35.4 µM 0.018751621331849 0.497903799341161 no 1676 0.492519623806314 2367 914301 YML130C ERO1 SGTC_3102 9121669 49.47 µM 0.0170683128711155 0.498591348130395 no 1677 0.493191058947271 2307 41905072 SGTC_1912 st060209 90.8 µM 0.0149127724168104 0.499471786314273 no 1678 0.494050885070467 2363 688787 SGTC_1585 2',4'-dihydroxychalcone 10.4 µM 0.012326372290502 0.499471786314273 no 1679 0.495082613453836 2391 5357218 A potent inhibitor of glutathione S-transferases. SGTC_2370 9071495 200 µM 0.0114654217956144 0.499120127466527 no 1680 0.495426058695239 2311 21791103 SGTC_401 neomycin 50 µM 0.0111540597481941 0.498992950483788 no 1681 0.495550266236004 2326 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis. SGTC_1150 3909-7983 10.9 µM 0.0097869815525319 0.498434563709892 no 1682 0.496095621591438 2378 23965914 SGTC_3065 9113888 49.47 µM 0.00937757789037256 0.498267342227594 no 1683 0.496258942522641 2382 16648368 SGTC_1888 azatryptophan 97.5 µM 0.00917548731941331 0.498184798169587 no 1684 0.49633956152686 2320 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides SGTC_149 3970-0822 46.1 µM 0.00905700443240941 0.498136403773974 no 1685 0.496386827395884 2385 3114250 YBL034C STU1 SGTC_2485 5633444 17.78 µM 0.00904845508337871 0.498132911789055 no 1686 0.496390237952928 2385 5724239 SGTC_2820 7989630 71.43 µM 0.00885598215731133 0.498054296186319 no 1687 0.496467020464029 2394 2984098 SGTC_3227 9130768 49.47 µM 0.00865485651785895 0.497972146461956 no 1688 0.496547254909804 2388 17720899 SGTC_1385 3091-4834 14.1 µM 0.00713239162741858 0.497350299039943 no 1689 0.497154611544093 2385 4072814 SGTC_1728 st035614 33.7865 µM 0.00698329724703611 0.497289402091247 no 1690 0.497214090114716 2354 15945546 SGTC_1603 st002045 67.8 µM 0.00563306562087298 0.496737908928471 no 1691 0.497752743840339 2397 5887985 SGTC_1621 st003705 32.4 µM 0.00552840215096588 0.496695160074368 no 1692 0.497794497873468 2387 24207032 SGTC_2721 ifenprodil 61.44 µM 0.00550191483686392 0.496684341574853 no 1693 0.497805064622252 2388 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor. SGTC_482 fipronil 114 µM 0.00494575631934356 0.496457184325586 no 1694 0.498026936739342 2394 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels. SGTC_2385 9074692 200 µM 0.00293666490219526 0.495636601621242 no 1695 0.498828441891063 2395 17046906 SGTC_1024 4507-0395 26 µM 0.00176224970285454 0.495156937997471 no 1696 0.499296964448789 2380 4201836 SGTC_2329 6138490 200 µM 0.000834513325682451 0.49477802973784 no 1697 0.499667077389469 2401 720019 SGTC_3076 9116187 49.47 µM 0.000504930097267711 0.494643421701766 no 1698 0.499798562044112 2404 27241210 SGTC_2039 Aminomethylbenzodioxan 200 µM -0.000300745231729798 0.494314371228713 no 1699 0.499880020013242 2408 15053 SGTC_2147 5545932 89.7195 µM -0.000364905632106006 0.494288167275668 no 1700 0.499854423718227 2408 797404 SGTC_3029 9088683 49.47 µM -0.00148675956889697 0.493829991427045 no 1701 0.49940686896569 2416 25236615 SGTC_2161 5662504 8.5105 µM -0.00249289517490721 0.493419082954151 no 1702 0.4990054797442 2412 2859334 SGTC_3290 9121031 71.43 µM -0.00400249325438845 0.4928025722949 no 1703 0.498403240477139 2413 17014854 SGTC_1680 diphenhydramine 100 µM -0.00403318749315682 0.49279003712812 no 1704 0.498390995346368 2422 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1 SGTC_1277 0873-0036 22 µM -0.00507994032582097 0.492362559902771 no 1705 0.49797340573843 2418 5965735 SGTC_1204 4049-0315 18.3 µM -0.00591461724307565 0.492021697373407 no 1706 0.497640422866749 2434 588402 SGTC_2260 7964312 200 µM -0.00750350708242259 0.491372848235819 no 1707 0.497006561863291 2419 231951 SGTC_2034 5197015 53.07 µM -0.0112027881356289 0.489862277736182 no 1708 0.495530827636536 2443 780676 SGTC_295 k015-0027 31 µM -0.0113967055614981 0.489783096997992 no 1709 0.49545347071536 2447 3887424 SGTC_2259 7964009 200 µM -0.0125095105452032 0.489328722196259 no 1710 0.495009557494003 2483 313134 SGTC_1455 4262-0120 131 µM -0.0125863260449253 0.489297357791129 no 1711 0.494978914955814 2441 1529587 SGTC_1025 k007-0731 70 µM -0.0140701501103314 0.488691513347604 no 1712 0.494387007429875 2438 6256118 SGTC_1547 harmine 94.2 µM -0.0142867492227412 0.48860307821381 no 1713 0.494300605571258 2435 5280953 A monoamine oxidase inhibitor YHR072W ERG7 SGTC_1594 piperine 70.1 µM -0.0155128903596155 0.488102468407423 no 1714 0.49381150035548 2433 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_1286 0929-0070 131 µM -0.0159259449925112 0.487933830339358 no 1715 0.493646735757404 2451 1420408 SGTC_2808 7946468 45.46 µM -0.0160913811091044 0.487866288238044 no 1716 0.493580744752405 2442 2970879 SGTC_2104 5389443 200 µM -0.0161200728817652 0.487854574370441 no 1717 0.493569299875656 2446 2244536 SGTC_2947 9072639 7.68 µM -0.0165911017733049 0.487662270920007 no 1718 0.493381411669487 2443 16488146 SGTC_1175 0741-0056 27.6 µM -0.016797254053648 0.487578107566774 no 1719 0.493299180268365 2438 765927 SGTC_1292 0kpi-0043 232 µM -0.0198068177848192 0.486349493500236 no 1720 0.49209873957276 2449 3333905 SGTC_710 3448-4187 58 µM -0.0200289121699066 0.486258831434059 no 1721 0.492010154306067 2450 3946412 SGTC_2746 daunorubicin 9.88 µM -0.0201859458111967 0.486194728511145 no 1722 0.491947519610331 2434 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_3203 9113543 49.47 µM -0.0214542674445232 0.485676998377397 no 1723 0.491441642174508 2498 17018012 SGTC_2539 epi(13)torulosol 80 µM -0.0219156404904471 0.485488671390361 no 1724 0.491257624232214 2464 6708597 SGTC_2757 clomiphene 4.22 µM -0.0231993518266843 0.484964692861075 no 1725 0.490745627818366 2452 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined. SGTC_2242 6630449 61.2675 µM -0.0242575605245509 0.484532778291098 no 1726 0.490323582477838 2572 691249 YDR170C SEC7 SGTC_404 fumagillin 50 µM -0.025556096439304 0.484002797497565 no 1727 0.489805702293625 2466 12015870 A methionine aminopeptidase binder. SGTC_1253 0550-0034 176 µM -0.0267980910539296 0.483495919740356 no 1728 0.489310387895398 2487 5969915 SGTC_1552 6-methylflavone 10.6 µM -0.0268451243875878 0.48347672520777 no 1729 0.48929163105805 2452 689013 SGTC_2567 aureobasidin a 60 nM -0.0269738036758963 0.483424210759194 no 1730 0.489240314032554 2533 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1 SGTC_2207 7258803 200 µM -0.0278911884533472 0.483049831344999 no 1731 0.488874468153324 2457 3666799 SGTC_3176 9106582 49.47 µM -0.028894436182846 0.482640428877308 no 1732 0.48847439152683 2447 17018027 SGTC_1174 0739-0097 51.1 µM -0.0291408413120933 0.482539879359329 no 1733 0.488376131480251 2481 728447 SGTC_3278 9139605 49.47 µM -0.0300455907816044 0.482170691573859 no 1734 0.488015346690747 2593 7958859 SGTC_3190 9110366 49.47 µM -0.0303954163288023 0.482027947498366 no 1735 0.487875850204057 2457 17123768 SGTC_2193 5925765 200 µM -0.0306709863636009 0.481915504530818 no 1736 0.487765964899988 2467 877370 SGTC_2225 6654152 15.4 µM -0.0312419384146613 0.481682539148309 no 1737 0.487538297103285 2468 97582 YGR029W | YLR033W ERV1 | RSC58 SGTC_3265 9137266 49.47 µM -0.0319791126430809 0.481381759447035 no 1738 0.487244354036569 2461 17224265 SGTC_1545 lovastatin 49.4 µM -0.0327014202818093 0.481087055847403 no 1739 0.486956345638628 2474 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12 SGTC_797 k781-0471 270 µM -0.0341918793350484 0.480478977103923 no 1740 0.486362071054106 2532 23738129 SGTC_1298 1079-1278 263 µM -0.0342659421542277 0.480448762065336 no 1741 0.486332541567848 2472 2840950 SGTC_3298 9116858 71.43 µM -0.0360774526062043 0.479709764586288 no 1742 0.485610300417633 2515 2506942 SGTC_2670 beta-carotene 100 µM -0.0362440716046168 0.479641796584576 no 1743 0.485543872499322 2475 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.) SGTC_511 blebbistatin 171 µM -0.0369401945505215 0.479357837279559 no 1744 0.485266345493792 2539 3476986 A myosin inhibitor. SGTC_2413 inermin 26.06 µM -0.0373540862259156 0.479189009427314 no 1745 0.485101340491461 2493 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1 SGTC_1694 st024011 44.9 µM -0.0381371542958708 0.478869603480268 no 1746 0.484789164001016 2473 2787533 SGTC_1142 3253-1408 9.78 µM -0.0387238260867606 0.478630314569968 no 1747 0.484555288591643 2459 256655 SGTC_2571 chrysanthemic acid 100 µM -0.0389638146834864 0.478532431373287 no 1748 0.484459619196076 2515 2743 An insecticide. SGTC_779 1360-0071 233 µM -0.0407384628742153 0.477808653236562 no 1749 0.483752199047455 2505 7566 SGTC_1677 st019204 53.9 µM -0.0419094181390455 0.477331127062445 no 1750 0.483285454203314 2569 3945625 SGTC_2533 agelasine 13.65 µM -0.0426228978571668 0.477040179477971 no 1751 0.483001071112026 2506 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase. SGTC_1219 1469-0211 33.1 µM -0.0438176992259751 0.47655298278087 no 1752 0.482524859345813 2485 6822282 SGTC_581 0958-0271 211 µM -0.0446426180020635 0.476216631207916 no 1753 0.482196086125446 2476 4591145 SGTC_444 curcumin 90.4 µM -0.0461646891648557 0.475596068058801 no 1754 0.481589493208815 2523 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. SGTC_2205 7238770 200 µM -0.0463841330513999 0.47550660350846 no 1755 0.481502041445767 2498 279867 SGTC_1702 st027038 51 µM -0.0465062801406828 0.475456806190078 no 1756 0.481453364337866 2525 5521182 SGTC_60 0986-0278 202 µM -0.0471086534063432 0.475211234340872 no 1757 0.481213315287731 2478 3110598 SGTC_2157 5649910 96.377 µM -0.0476714016509377 0.474981825083914 no 1758 0.480989063178474 2489 2858091 SGTC_2853 9015042 58.44 µM -0.0485495933878413 0.474623839120713 no 1759 0.480639120602035 2497 6457456 SGTC_1445 4239-0156 97.7 µM -0.0494608822309491 0.474252383121447 no 1760 0.480276005240479 2582 4008346 SGTC_716 1683-5115 658 µM -0.049786681835144 0.474119587373965 no 1761 0.480146189938813 2488 723597 SGTC_1411 3909-8223 150 µM -0.0519006478965354 0.473258006434676 no 1762 0.479303929013289 2500 X1411 SGTC_470 aa-861 153 µM -0.0519486537015593 0.473238442332452 no 1763 0.479284803268472 2509 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor. SGTC_310 1273-0058 1.06 µM -0.0520514096728783 0.473196565773826 no 1764 0.47924386495307 2497 2734232 SGTC_375 3970-0961 9.27 µM -0.0522494907032302 0.47311584184275 no 1765 0.479164949440297 2528 2898222 SGTC_3261 9137475 49.47 µM -0.0522532116459273 0.473114325458114 no 1766 0.479163467023964 2484 17027690 SGTC_630 4356-0227 183 µM -0.0529054699454642 0.472848518626075 no 1767 0.478903613057964 2493 779312 SGTC_245 methotrexate 289.6 µM -0.0546932509794651 0.47212002846251 no 1768 0.478191423127262 2538 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2 SGTC_2508 celastrol 40.54 µM -0.0569238555587879 0.471211226333058 no 1769 0.477302925566427 2489 122724 Celastrol is a natural product and antioxidant. SGTC_1623 st003709 20.3 µM -0.0569578099075791 0.471197393658295 no 1770 0.477289401682835 2504 16192618 SGTC_2211 7117706 200 µM -0.060225172154277 0.469866466762467 no 1771 0.475988148809476 2507 822771 SGTC_1784 st039334 36.3 µM -0.0602252429187173 0.469866437940881 no 1772 0.475988120629701 2654 3496984 SGTC_2921 7974240 10.71 µM -0.0613243714019954 0.469418794014829 no 1773 0.475550440876934 2564 2979074 YDR527W RBA50 SGTC_1611 st001856 99.4 µM -0.0634875657050915 0.468537899616163 no 1774 0.474689130199659 2531 647478 SGTC_3128 9127691 49.47 µM -0.0643783027405639 0.468175218852994 no 1775 0.474334503043368 2648 41316314 SGTC_222 nsc-310342 10.666 µM -0.0645486437651445 0.468105864218831 no 1776 0.47426668785748 2511 432556 SGTC_1937 st074714 47.2 µM -0.0650276863461624 0.467910826423594 no 1777 0.474075978192442 2523 17250970 SGTC_501 nsc-95397 161 µM -0.0655425625129 0.467701207902114 no 1778 0.473871009591581 2609 262093 SGTC_1773 st048542 73.5835 µM -0.0657445121049047 0.467618991788313 no 1779 0.473790616757021 2524 3237138 SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM -0.0659083573067023 0.467552289445973 no 1780 0.473725393442054 2540 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_1437 4092-1038 11.6 µM -0.0666455437933866 0.467252187803184 no 1781 0.473431943807343 2529 3977136 SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM -0.0667910735429376 0.467192946213872 no 1782 0.473374014911221 2512 6708561 SGTC_1911 st060208 74.3 µM -0.0685205760529938 0.466488964187654 no 1783 0.472685620623006 2608 688783 SGTC_3284 9108171 64.8615 µM -0.0701977577400048 0.465806379087502 no 1784 0.472018129494481 2588 8687505 SGTC_638 3970-0837 4.09 µM -0.0703217953353912 0.465755901815363 no 1785 0.471968767639659 2562 4118451 YLR208W SEC13 SGTC_3297 9117502 71.43 µM -0.070379303094363 0.465732499139657 no 1786 0.471945882065925 2513 7453720 SGTC_882 0843-0131 351 µM -0.0705758492362748 0.465652515947357 no 1787 0.471867665994494 2520 5425421 SGTC_1132 3456-3614 2.5 µM -0.0706239520116007 0.465632941042559 no 1788 0.471848523529444 2649 3125502 SGTC_360 0957-0399 1.01 µM -0.0711141534560394 0.465433463609674 no 1789 0.471653451930891 2605 6752301 YPR165W RHO1 SGTC_359 0081-0058 15.9 µM -0.0712056297393215 0.465396240170776 no 1790 0.471617050454248 2667 3494159 SGTC_2460 5552655 174.22 µM -0.0717249745908351 0.465184914625052 no 1791 0.471410390248328 2653 5401989 SGTC_65 0798-0905 34.986 µM -0.0718120721047686 0.465149474914505 no 1792 0.471375732738126 2612 3602145 SGTC_1378 2093-0007 380 nM -0.072867489765767 0.464720050766378 no 1793 0.470955782277495 2587 3618014 SGTC_1755 st041960 45.185 µM -0.0734084894427039 0.464499946862608 no 1794 0.470740531112928 2616 2257073 SGTC_2867 9039098 71.43 µM -0.0749847672064589 0.4638587057195 no 1795 0.470113415888394 2521 6463460 SGTC_2065 5221596 34.26 µM -0.0755830657167213 0.463615338066004 no 1796 0.469875404760516 2638 788581 SGTC_45 0kpi-0036 14.9 µM -0.0770358737536836 0.463024441607809 no 1797 0.469297503310947 2606 2795021 SGTC_2564 betulinic acid 100 µM -0.0776745459954694 0.462764702009653 no 1798 0.469043471135295 2554 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14 SGTC_1570 verbenone 133 µM -0.0785212830067513 0.462420369700516 no 1799 0.468706700548541 2585 29025 A natural terpanoid with antifungal properties. SGTC_2699 st077704 54.6 µM -0.0785691569753513 0.462400902210841 no 1800 0.468687660421635 2587 645852 SGTC_2603 homopterocarpin 100 µM -0.0785792681686423 0.462396790602689 no 1801 0.468683639072025 2623 101795 A weak amylase inhibitor. SGTC_44 0929-0055 61.211 µM -0.0788248321760398 0.462296935871354 no 1802 0.468585976138747 2555 1379590 SGTC_2848 9016370 25.97 µM -0.079695269594776 0.461943005402616 no 1803 0.468239810902301 2547 7894410 SGTC_2166 5933061 31.504 µM -0.081304122132044 0.461288905871696 no 1804 0.467600047929194 2874 2877375 SGTC_891 0929-0073 133 µM -0.0815255528852448 0.461198888530688 no 1805 0.467512002124155 2701 5603632 SGTC_2456 5770359 74.46 µM -0.0826948764512133 0.4607235612669 no 1806 0.467047079459872 2567 3118787 SGTC_464 bw-b 70c 158 µM -0.0842289121975041 0.460100064565216 no 1807 0.466437215625539 2673 5353454 SGTC_173 1273-0061 2.693 µM -0.0846463715268639 0.459930408437124 no 1808 0.466271266092094 2640 2847414 YPL266W DIM1 SGTC_1324 1418-0026 34.4 µM -0.084724008760232 0.459898857346985 no 1809 0.466240404180182 2654 1372513 SGTC_225 nsc-122657 1.016 µM -0.0850747428731843 0.459756325232324 no 1810 0.466100984881031 2668 275685 SGTC_2726 cimetidine 79.27 µM -0.0851211269488418 0.459737475954547 no 1811 0.466082547192845 2561 2756 A P450 inhibitor, histamine H2-receptor antagonist. SGTC_67 0335-0847 266 µM -0.0858447048346819 0.459443444529717 no 1812 0.465794934150871 2891 4552207 YOR254C SEC63 SGTC_1825 st052143 62.6 µM -0.0873894703245355 0.458815791652533 no 1813 0.465180969411054 2631 674173 SGTC_2763 lisinopril 49.32 µM -0.0875313470910581 0.458758150899415 no 1814 0.465124584835172 2540 5362119 A lysine-analog of enalapril and an ACE inhibitor. SGTC_778 3456-2434 196 µM -0.088089227817442 0.45853150723226 no 1815 0.464902879026213 2729 5539063 SGTC_1209 2323-2347 50.3 µM -0.0886871650212167 0.458288605258104 no 1816 0.464665266583744 2542 5412760 SGTC_539 4859-0462 2.54 µM -0.0902616122505017 0.457649087178209 no 1817 0.464039662288287 2671 46499474 YNL221C | YBR257W POP1 | POP4 SGTC_58 0957-0393 9 µM -0.0905685593622377 0.457524422344514 no 1818 0.463917707611093 2564 6997992 SGTC_995 3931-2021 34.6 µM -0.0930898583882566 0.4565005702607 no 1819 0.462916087141973 2648 730143 SGTC_1735 st034310 56.75 µM -0.0931084210130641 0.456493033390478 no 1820 0.462908713749697 2797 871153 SGTC_2412 st077135 33.4 µM -0.0932830624160382 0.456422125565167 no 1821 0.46283934381971 2861 13258915 SGTC_255 tunicamycin 200.472 nM -0.0942292702552099 0.456037970860491 no 1822 0.462463516955988 2627 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_1997 st073024 93.8 µM -0.0946178998806716 0.455880201448968 no 1823 0.46230916578704 2557 686268 SGTC_3340 9146634 11.102 µM -0.0959183284793439 0.455352325734289 no 1824 0.461792718838151 2627 4907387 SGTC_281 1672-3440 14.9 µM -0.0966423727360921 0.455058452593698 no 1825 0.461505202694405 2644 6833000 SGTC_2650 prasterone 100 µM -0.0970936858276267 0.454875287278621 no 1826 0.461325997575446 2573 16759247 A steroid and weak partial agonist of the androgen receptor. SGTC_941 3237-0776 460 µM -0.0974315419200233 0.454738174737646 no 1827 0.461191848525243 2678 760008 SGTC_48 0382-0018 55 µM -0.0975781850864909 0.454678664043765 no 1828 0.461133623801945 2609 762596 SGTC_3041 9091929 49.47 µM -0.09831560237233 0.454379420987572 no 1829 0.460840844650787 2670 25236887 SGTC_2661 dactinomycin 12.96 µM -0.0988174369815285 0.45417579189597 no 1830 0.460641611773399 2591 45006140 An Actinomycin D Classic transcription inhibitor. SGTC_875 0709-0210 25.7 µM -0.0990321081384662 0.454088688599981 no 1831 0.460556388397244 2574 6251364 SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM -0.100999644361431 0.45329045981966 no 1832 0.459775371246065 2607 279621 SGTC_777 1315-0167 517 µM -0.101838906309993 0.452950028751181 no 1833 0.459442271702147 2681 4221767 SGTC_1178 0988-0033 191 µM -0.103159657329061 0.452414360677758 no 1834 0.458918128910094 2713 5392207 SGTC_130 0136-0219 337.655 µM -0.103620276932598 0.452227563638338 no 1835 0.458735347809955 2567 234244 SGTC_426 0988-0037 14.6 µM -0.104681965000687 0.451797053073844 no 1836 0.45831408658428 2559 5383008 SGTC_274 sirtinol 40.1 µM -0.105727983207575 0.45137295200626 no 1837 0.457899088697094 2624 6836442 NAD-dependent acetyltransferase inhibitor. SGTC_1562 morin hydrate 59.1 µM -0.108793669890293 0.450130311345178 no 1838 0.456683072356337 2734 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase. SGTC_793 0488-0545 106 µM -0.109893650088821 0.449684565601347 no 1839 0.456246859269045 2598 292548 SGTC_216 k038-0035 28.382 µM -0.110246786771093 0.449541477210998 no 1840 0.45610682895626 2576 4444231 YPR107C YTH1 SGTC_2173 5763948 167 µM -0.111140489768658 0.449179384673454 no 1841 0.455752470710305 2610 2867177 SGTC_2496 diffractaic acid 79.83 µM -0.111340362589611 0.449098410019057 no 1842 0.455673224822859 2711 94870 An apoptosis inducer which activates caspases. SGTC_2290 7904846 200 µM -0.112694087230813 0.448550030319757 no 1843 0.45513654454689 2666 2962154 SGTC_2382 9035899 200 µM -0.113671224675408 0.448154263173284 no 1844 0.454749212009773 2627 6462679 SGTC_212 3807-4682 38.772 µM -0.113863584732124 0.448076358203501 no 1845 0.454672966474091 2681 3125501 YBL034C STU1 SGTC_2321 7390090 138.78 µM -0.114217480146988 0.447933037363568 no 1846 0.45453269771763 2692 649046 SGTC_1365 1672-3266 55.4 µM -0.114599153701444 0.447778474529517 no 1847 0.454381425269531 2637 6415873 SGTC_1214 0358-0031 63.7 µM -0.116065549049453 0.447184715826942 no 1848 0.453800296058175 2908 4301366 SGTC_2815 7968870 71.43 µM -0.116803510826494 0.446885952125689 no 1849 0.453507880780669 2628 2977326 YHR190W ERG9 SGTC_3356 9151811 4.48 µM -0.117337917504624 0.446669616479315 no 1850 0.45329613936397 2614 1859254 YPR165W RHO1 SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM -0.118654026936847 0.446136903916682 no 1851 0.452774730170036 2596 1241132 A phosphatase inhibitor. SGTC_1263 0774-1208 64.8 µM -0.119568216570108 0.44576693081976 no 1852 0.452412599277178 2659 906585 SGTC_1006 4099-6547 255 µM -0.120463982290118 0.445404459690152 no 1853 0.452057804898255 2709 3146833 SGTC_1724 st037281 8.293 µM -0.122625428806471 0.444530019972579 no 1854 0.45120185856676 2633 574124 YDL195W SEC31 SGTC_100 0086-0128 49.5915 µM -0.123184984464025 0.444303688673748 no 1855 0.450980307833095 2648 93297 SGTC_19 0279-0214 38.434 µM -0.124403415365743 0.443810915821171 no 1856 0.45049793464303 2626 3566274 YBR002C RER2 SGTC_2164 5685496 200 µM -0.126026046502466 0.443154806317864 no 1857 0.449855653411209 2629 759046 SGTC_1886 st057356 49.9 µM -0.126587356994098 0.442927877089334 no 1858 0.449633502045764 2620 24207747 SGTC_3323 9138564 53.9225 µM -0.126932530472227 0.442788338033476 no 1859 0.449496899641731 2682 43912313 YNL103W MET4 SGTC_1435 4092-0789 56.7 µM -0.12712972338029 0.442708624454758 no 1860 0.449418863233503 2643 2248285 SGTC_883 0850-0245 24.6 µM -0.127715788046206 0.44247172643166 no 1861 0.449186947680839 2831 6823229 YPR165W RHO1 SGTC_2491 paeonol 100 µM -0.127799287885944 0.442437975946158 no 1862 0.449153906813986 2615 11092 Increases levels of cortical cytochrome oxidase. SGTC_323 4013-0906 34.3 µM -0.12821510748129 0.44226990863651 no 1863 0.44898937235267 2748 2910086 SGTC_1727 st034309 9.9045 µM -0.128312932613671 0.442230370866564 no 1864 0.448950665480554 2946 870305 SGTC_824 1304-0008 100 µM -0.128520963682738 0.442146293317578 no 1865 0.448868354588242 2648 768245 SGTC_2686 alizarin 95.37 µM -0.129977205908179 0.441557813656554 no 1866 0.448292230369204 2694 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1 SGTC_303 1348-1668 34.2 µM -0.132079168387194 0.440708620826216 no 1867 0.447460836382472 2681 5380509 SGTC_180 1486-1293 102.781 µM -0.132353614410676 0.440597764669881 no 1868 0.447352301080649 2659 4140536 SGTC_1609 st001574 46.4 µM -0.133095750168153 0.440298019345857 no 1869 0.44705882806018 2657 3960012 SGTC_324 1315-0088 19.6 µM -0.134676481038413 0.439659683442003 no 1870 0.446433834582636 2705 6787421 SGTC_2634 4'-methoxyflavone 100 µM -0.136320204729407 0.438996075932148 no 1871 0.445784075958693 2701 77793 From seeds of Psoralea corylifolia (Fabaceae) SGTC_235 0330-0087 5 mM -0.136420184925697 0.438955717233642 no 1872 0.445744558791869 2657 46494818 YHR062C RPP1 SGTC_1660 st012960 28.1 µM -0.137272047989702 0.43861187407058 no 1873 0.44540788186443 2722 24207266 SGTC_31 0508-1974 57.237 µM -0.138219239667866 0.43822960718861 no 1874 0.445033574991327 2678 6810525 SGTC_572 0960-0087 17.7 µM -0.139578997550586 0.437680937990567 no 1875 0.444496317841226 2655 6796365 SGTC_726 3448-4391 34.2 µM -0.140423024024148 0.437340429222967 no 1876 0.444162883770422 2800 1356692 SGTC_2751 anetholtrithion 17.25 µM -0.140696776748681 0.437229998088351 no 1877 0.444054745774163 2771 2194 A chloretic substance that stimulates the liver to produce bile. SGTC_2337 9009472 200 µM -0.14152328311257 0.436896617282572 no 1878 0.443728283944044 2740 5742383 SGTC_1806 st050005 60.3 µM -0.141556433494127 0.436883246629679 no 1879 0.443715190666583 2660 5194765 SGTC_1907 st060210 83.7 µM -0.141748106343488 0.436805940000299 no 1880 0.443639487590737 2812 688793 SGTC_2062 5245942 200 µM -0.142092504972364 0.436667041170092 no 1881 0.443503469136871 2626 1376160 SGTC_1996 st072960 66.8 µM -0.142791505906285 0.43638515230567 no 1882 0.443227422821016 2639 1719405 SGTC_2493 resveratrol 26.09 µM -0.143004405765614 0.436299301751016 no 1883 0.443143350830377 2631 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase. SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM -0.145878196220083 0.435140758734204 no 1884 0.442008772168062 2719 4213774 SGTC_2669 eugenol 100 µM -0.146235699744744 0.434996673096903 no 1885 0.441867662077926 2658 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism. SGTC_556 4058-0063 51.5 µM -0.147370307131295 0.434539446390667 no 1886 0.441419870539305 2679 6615692 SGTC_1229 0139-0193 12.2 µM -0.1483836793433 0.434131149305361 no 1887 0.441019989742589 2744 3090752 SGTC_3119 9125183 49.47 µM -0.149655985025987 0.433618625049538 no 1888 0.440518017925299 2731 22695334 SGTC_946 3434-1334 87.4 µM -0.150042876812223 0.433462795106554 no 1889 0.440365393667957 2802 4047976 SGTC_1999 st074831 12.5 µM -0.15129194331073 0.432959774345163 no 1890 0.439872712217963 2704 17112523 SGTC_3354 9151612 71.43 µM -0.152357548788567 0.432530722338182 no 1891 0.439452468642732 2797 27261949 SGTC_2674 ligustilide 100 µM -0.152961955077278 0.432287401428408 no 1892 0.43921413880496 2766 5319022 A signalling regulator. SGTC_977 1348-1378 135 µM -0.153115996473652 0.432225391794029 no 1893 0.439153400632231 2661 X977 SGTC_406 estrone 100 µM -0.154440808539148 0.431692155451826 no 1894 0.438631089531978 2824 5870 A steroid. SGTC_138 0850-0259 40.9225 µM -0.154481942412363 0.431675601070725 no 1895 0.43861487408579 2718 6813004 SGTC_2283 7944793 200 µM -0.154885371838579 0.431513246734163 no 1896 0.438455843028558 2727 2970533 SGTC_1646 st011709 75.6 µM -0.154893337105925 0.431510041343921 no 1897 0.43845270323636 2698 5757843 SGTC_1127 asiatic acid 681.4 nM -0.155279302380912 0.431354726249439 no 1898 0.438300566000396 2681 470603 A kinase inhibitor which arrests cells at G2/M. SGTC_2783 7738165 71.43 µM -0.156541646150601 0.430846824634776 no 1899 0.43780304748602 2744 17201110 SGTC_815 1582-0027 36.9 µM -0.157076047768147 0.430631843564115 no 1900 0.437592457173964 2765 3128206 SGTC_2416 tofa 880 nM -0.157597945145627 0.430421912585303 no 1901 0.437386811437144 2722 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_2437 5741531 144.16 µM -0.157883444132665 0.43030708016061 no 1902 0.437274322049947 2834 2262990 SGTC_1909 st060837 51.5 µM -0.158105001155901 0.430217970314725 no 1903 0.437187029914243 2747 678937 SGTC_1744 st037937 38.9 µM -0.159349362683972 0.429717556451766 no 1904 0.436696815883457 2835 1016152 SGTC_271 rotenone 740 µM -0.159415686694665 0.429690887739291 no 1905 0.436670690378048 2823 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria. SGTC_2749 bexarotene 57.39 µM -0.159956250383986 0.429473540457544 no 1906 0.436457768758451 2799 82146 An retinoic acid receptor inhibitor. SGTC_1994 st072947 40.9 µM -0.161339055246538 0.428917646278877 no 1907 0.435913182264768 2790 5286565 YDL195W SEC31 SGTC_290 2043-6722 48.1 µM -0.162112242502332 0.428606882673511 no 1908 0.435608732799226 2758 773758 YLR208W SEC13 SGTC_3140 9094243 49.47 µM -0.162427786016769 0.428480070423124 no 1909 0.435484495644319 2653 19291112 SGTC_1698 5-fluorocytosine 1.055 µM -0.16265216512676 0.428389900284013 no 1910 0.435396156005333 2721 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_2816 7982706 58.44 µM -0.165863789781088 0.427099672282654 no 1911 0.434132072144666 2808 2981853 SGTC_646 4092-0839 27.3 µM -0.166160480475568 0.426980519814776 no 1912 0.434015329532888 2818 877796 SGTC_2118 5526350 200 µM -0.166622537934475 0.426794968497166 no 1913 0.433833529448803 2847 743594 SGTC_2790 5423970 71.43 µM -0.167394288873813 0.426485087764012 no 1914 0.43352990929741 2846 1376240 YKL165C | YIL048W MCD4 | NEO1 SGTC_119 0121-0043 24.815 µM -0.167989319349596 0.426246196471781 no 1915 0.433295840797796 2686 1092378 SGTC_206 4546-0025 72.014 µM -0.169684600729854 0.425565727959727 no 1916 0.432629092638058 2726 6620745 YIL048W NEO1 SGTC_1120 ficusin 1.78878 µM -0.170694952647387 0.425160288365312 no 1917 0.432231815893342 2845 6199 A DNA cross-linker. SGTC_2105 5350118 200 µM -0.171265512482228 0.424931365902295 no 1918 0.432007498411315 2749 2133313 SGTC_455 paf C-16 10 µM -0.171438528520547 0.424861952663862 no 1919 0.431939480912651 2690 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis. SGTC_151 3013-0144 2.285 µM -0.171792985891241 0.424719753275525 no 1920 0.431800139996505 2954 906558 YHR107C CDC12 SGTC_1496 4469-0713 57.4 µM -0.172286328680682 0.424521852857452 no 1921 0.431606215889638 2769 746691 SGTC_1644 st010134 20.9 µM -0.172960976781491 0.424251254106963 no 1922 0.431341050641784 2740 3818134 SGTC_2662 daunorubicin 22.37 µM -0.17296110252582 0.424251203674722 no 1923 0.431341001221823 2677 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_2920 7982904 15.77 µM -0.173798848259869 0.423915236808686 no 1924 0.431011774787269 2815 6456808 SGTC_1947 st076332 61.6 µM -0.17383578697963 0.423900424293793 no 1925 0.430997259308902 2802 24208416 SGTC_3281 9140613 49.47 µM -0.175260120295648 0.423329345427175 no 1926 0.430437623055268 2752 16013766 SGTC_126 0417-1624 672.48 µM -0.176610097909074 0.422788227702621 no 1927 0.429907330894949 2734 41912 YDL195W SEC31 SGTC_383 2324-0395 7.37 µM -0.176618465511436 0.422784874131309 no 1928 0.429904044364111 2848 3146421 SGTC_2984 9022109 38.96 µM -0.176764658802297 0.422726283623829 no 1929 0.429846625024823 2737 6459207 SGTC_1487 3970-0795 2.82 µM -0.176778730564082 0.422720644114127 no 1930 0.429841098233425 2800 3765103 SGTC_3052 9092717 49.47 µM -0.177031950236001 0.422619164518909 no 1931 0.429741646633298 2887 25237534 SGTC_1191 1487-1166 10.6 µM -0.177257972885358 0.42252858866253 no 1932 0.429652880383432 2835 3955771 SGTC_1711 st032263 62.8 µM -0.177980905329577 0.422238909712924 no 1933 0.429368985825942 2763 3958979 SGTC_2276 7947513 42.08 µM -0.17846934442597 0.422043216019542 no 1934 0.429177197144469 2811 2105100 SGTC_1514 1189-1591 158 µM -0.178647434524475 0.421971868799375 no 1935 0.429107273104476 2924 767698 YMR146C TIF34 SGTC_1749 st037932 54.2 µM -0.179465949905567 0.421643984619312 no 1936 0.428785925640919 2852 594497 SGTC_2463 5473429 200 µM -0.180255512658597 0.421327749865071 no 1937 0.428475989643758 2792 5399405 SGTC_2236 dapsone 200 µM -0.180303182550768 0.421308658797585 no 1938 0.428457278651877 2747 2955 A bacterial DFR inhibitor. An anti-cancer agent. SGTC_163 TUB2.036 7.546 µM -0.182030754819078 0.420616917537563 no 1939 0.427779295118858 2769 15992207 YJR013W GPI14 SGTC_1471 k673-0312 37 µM -0.182378608684284 0.420477662127717 no 1940 0.427642806033197 2733 24099884 SGTC_1949 st076024 69.1 µM -0.182496757808314 0.420430366067415 no 1941 0.427596449265156 2673 2921930 SGTC_186 3455-3465 67.277 µM -0.182591504414752 0.420392439056194 no 1942 0.427559275387023 2724 755278 SGTC_2 0422-0095 29 µM -0.182683459707699 0.420355630112882 no 1943 0.427523197297082 2685 6790840 SGTC_3011 9081274 71.4286 µM -0.183593453525563 0.419991404714147 no 1944 0.427166199578142 2768 6625322 SGTC_2910 7948405 25.97 µM -0.184231421076322 0.419736098775276 no 1945 0.426915955443661 2832 2971328 SGTC_916 4466-0038 42 nM -0.184920945586173 0.419460198428791 no 1946 0.426645521056424 2832 5722064 YGL116W CDC20 SGTC_2093 5331342 194.4 µM -0.18545248571624 0.419247539595504 no 1947 0.426437072330128 2866 33839 SGTC_705 1124-0212 310 µM -0.185565838775123 0.419202192297982 no 1948 0.426392622461591 2782 9554485 SGTC_211 3455-0679 143.504 µM -0.185667093393572 0.419161685932451 no 1949 0.426352917623386 2785 748649 SGTC_345 1362-0200 395 µM -0.185684847041309 0.419154583769431 no 1950 0.426345955986128 2751 1419823 SGTC_656 4090-1979 187 µM -0.185714447037556 0.419142742655879 no 1951 0.426334349158404 2827 22330961 SGTC_1289 0976-0073 69.1 µM -0.188535824026033 0.418014423262101 no 1952 0.425228317753065 2853 3391136 SGTC_1071 trifluoperazine 6.31 µM -0.188957219013244 0.417845957495153 no 1953 0.425063173485509 2886 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. SGTC_2181 6316240 54.2555 µM -0.189852893806559 0.417487933717033 no 1954 0.424712203155476 2820 12779990 SGTC_3019 9081971 49.47 µM -0.190868980384848 0.417081861130311 no 1955 0.424314121709886 2885 16451803 SGTC_3149 9097855 49.47 µM -0.190911949741502 0.417064690644216 no 1956 0.424297288914201 2893 25236625 YMR079W SEC14 SGTC_1924 st058459 75.1 µM -0.192137254328763 0.416575127586114 no 1957 0.423817346894328 2727 688683 SGTC_394 menadione 8.33 µM -0.192490222742816 0.416434125152938 no 1958 0.423679112915371 2750 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_1155 4088-0394 48.2 µM -0.192603896658485 0.416388717432599 no 1959 0.42363459648949 2726 2326248 SGTC_1009 4106-0057 9.87 µM -0.192617032033726 0.416383470500899 no 1960 0.423629452540544 2746 2928005 SGTC_2299 7976368 114.88 µM -0.193127903292763 0.416179414308497 no 1961 0.423429400170772 2886 2979718 SGTC_2467 5474540 200 µM -0.193836476645613 0.415896427808708 no 1962 0.423151962207028 2736 5413519 SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM -0.194178176055531 0.415759977173149 no 1963 0.423018185308908 2876 6708760 SGTC_837 0091-0265 12.5 µM -0.194217404789636 0.415744312634141 no 1964 0.423002827645919 2750 759367 SGTC_2677 mitomycin C 100 µM -0.194387517219124 0.41567638609842 no 1965 0.422936231659561 2765 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_1491 4138-0063 26.5 µM -0.194893630618666 0.415474308012511 no 1966 0.422738110307141 2737 23883227 SGTC_2097 5376186 200 µM -0.195390656247359 0.415275880194857 no 1967 0.422543565439118 2862 742755 SGTC_1260 0700-1617 7.75 µM -0.195771049558447 0.415124030155908 no 1968 0.422394685340816 2860 2853078 SGTC_159 3970-0959 50 µM -0.195838910729151 0.415096941838536 no 1969 0.422368126685837 2849 6615653 SGTC_1850 st056238 17 µM -0.195919569096726 0.415064745756273 no 1970 0.422336560083327 2713 5393177 SGTC_2831 7999036 19.48 µM -0.196634891409592 0.414779238356461 no 1971 0.422056632119203 3053 2988270 SGTC_326 k292-0812 17.5 µM -0.197316692743836 0.414507152114974 no 1972 0.421789858605939 2804 3579357 SGTC_2835 9006588 71.43 µM -0.198418532229242 0.414067528139394 no 1973 0.421358809532232 2996 2345538 SGTC_2107 5363541 170.161 µM -0.198469542085558 0.414047178271888 no 1974 0.42133885631642 2778 244052 SGTC_1000 4048-0884 8.67 µM -0.200848009526702 0.413098569831418 no 1975 0.420408710789876 2890 13040088 SGTC_2210 7115885 190.385 µM -0.20490860654175 0.411480249433538 no 1976 0.41882176542392 2775 2927039 SGTC_895 0964-0006 13.7 µM -0.205011264127147 0.41143935541351 no 1977 0.418781662220565 2773 6738897 SGTC_1162 k048-0130 20.1 µM -0.20511090850861 0.411399662634316 no 1978 0.418742736933045 2770 6797406 SGTC_1576 erythromycin ethylsuccinate 23.2 µM -0.205376597682956 0.411293831279042 no 1979 0.418638951453422 2758 3256 An antibiotic and ribosome inhibitor. SGTC_210 3551-0445 56.827 µM -0.205848057730871 0.411106051580804 no 1980 0.418454800170839 2903 2865180 YOR207C RET1 SGTC_436 n,n-dimethylsphingosine 3.3 µM -0.20605797962835 0.411022447503541 no 1981 0.418372810876094 3112 5282309 SGTC_568 1193-0097 7.48 µM -0.206096840778021 0.411006970997476 no 1982 0.418357633247423 2836 3646150 SGTC_91 0417-1751 58.384 µM -0.206583476626687 0.410813179340174 no 1983 0.418167582823471 2739 6795624 SGTC_718 1130-0073 349 µM -0.206618034491962 0.410799418283651 no 1984 0.418154087344963 2940 6740020 SGTC_131 0141-0277 33.849 µM -0.206948135767269 0.41066797639686 no 1985 0.418025181617473 2938 1547771 SGTC_2560 caryophyllene 100 µM -0.209497460866238 0.409653208409393 no 1986 0.417029958672934 2764 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor. SGTC_2308 7584454 197.62 µM -0.210834658465618 0.409121173546279 no 1987 0.416508146412657 2928 893577 SGTC_1819 st053448 58.6 µM -0.211353242290742 0.408914888014516 no 1988 0.416305819896047 2806 2857616 SGTC_3107 9121808 49.47 µM -0.212899545114606 0.408299939934303 no 1989 0.415702658597811 2781 662681 SGTC_1642 st009582 77.7 µM -0.212987827773977 0.408264837664129 no 1990 0.415668228446748 2907 6739311 SGTC_2558 carylophyllene oxide 100 µM -0.214449980286391 0.407683575119708 no 1991 0.415098084738183 2771 6708694 An oxygenated terpenoid and antifungal agent. SGTC_518 1021-0119 62.6 µM -0.21460380364926 0.407622436133804 no 1992 0.415038114073427 2831 1097762 SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM -0.215277293705533 0.407354775743772 no 1993 0.414775565800886 2723 4000243 SGTC_1517 deoxycholic acid methyl ester 49.2 µM -0.21686374263696 0.406724455709355 no 1994 0.41415726717543 2778 229346 A bile salt which induces apoptosis. SGTC_53 0973-0023 39.979 µM -0.217036660573623 0.406655767381835 no 1995 0.414089887400475 2764 674768 SGTC_613 3914-0030 117 µM -0.218632515368788 0.406021980544679 no 1996 0.41346816095032 2739 1145395 SGTC_1507 4075-3230 155 µM -0.219069253747555 0.40584857462476 no 1997 0.413298050498167 2741 659771 SGTC_450 aminopyrene 156 nM -0.219899856647462 0.405518836744433 no 1998 0.412974573979197 2875 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1 SGTC_1775 st081588 35.1725 µM -0.220240599219415 0.405383586027519 no 1999 0.412841889591831 2818 1426443 YGL099W LSG1 SGTC_1723 st034307 2.5525 µM -0.220366790415728 0.405333499907766 no 2000 0.412792753550981 2883 867466 SGTC_366 0181-0206 4.31 µM -0.220739882234638 0.405185426369453 no 2001 0.412647487902194 2954 274874 SGTC_122 0236-0016 402.397 µM -0.221331390313645 0.404950695106569 no 2002 0.412417205033186 2838 6808838 SGTC_1362 1611-0397 101 µM -0.221554274902796 0.404862255507777 no 2003 0.412330440572318 2817 27816 SGTC_456 gingerol 170 µM -0.222256361651724 0.404583702437091 no 2004 0.412057160429696 2978 442793 A herb. SGTC_1865 st057639 52.2 µM -0.222800171746127 0.404367978886599 no 2005 0.411845517166807 2765 688818 SGTC_442 cape 100 µM -0.223083429922447 0.404255624959585 no 2006 0.411735287209362 2928 5281787 SGTC_490 phenamil 164 µM -0.224155097734927 0.403830621069015 no 2007 0.411318310631948 2898 4755 Irreversibly blocks amiloride-sensitive Na+ channels. SGTC_1139 k015-0024 46.9 µM -0.224381234794351 0.403740953726378 no 2008 0.411230335460446 2863 2766652 SGTC_1969 st069479 40.1 µM -0.22465089025512 0.403634037181147 no 2009 0.411125435954497 2985 3895485 SGTC_443 clozapine 122 µM -0.224940633506793 0.403519163989825 no 2010 0.411012729117127 2772 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_3277 9138724 49.47 µM -0.22565327059335 0.403236663429793 no 2011 0.41073555264572 2869 15943418 SGTC_2524 avocatin b 10.57 µM -0.227809323771752 0.402382278046965 no 2012 0.409897238974706 2912 6710748 SGTC_588 3970-1144 52.9 µM -0.227887659293052 0.402351244555874 no 2013 0.409866788391235 2951 1888707 SGTC_2601 securinine 100 µM -0.228563424126203 0.402083558348655 no 2014 0.409604127678053 2819 442872 A GABA receptor antagonist. SGTC_451 chloral hydrate 100 µM -0.229235487983565 0.401817383726855 no 2015 0.409342945717753 2929 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1 SGTC_829 1635-0120 117 µM -0.229509547296673 0.401708854078331 no 2016 0.409236450493435 2949 285054 SGTC_789 1309-1135 70.6 µM -0.229777741103529 0.401602654555089 no 2017 0.409132240999127 2790 3092424 SGTC_2063 5246145 200 µM -0.23066830666954 0.401250060108455 no 2018 0.408786248587375 2934 711240 SGTC_1054 3429-0080 167 µM -0.231072701670816 0.401089977782247 no 2019 0.408629161084738 2988 1162877 SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM -0.23219922897218 0.40064412243792 no 2020 0.408191638292194 3000 6728940 SGTC_839 0122-0028 230 µM -0.2328389234518 0.400391002652312 no 2021 0.407943243452157 2827 759448 SGTC_548 1436-0017 110 µM -0.232940467659583 0.400350826615549 no 2022 0.407903817002209 2937 9677137 SGTC_1442 4112-3290 3 µM -0.235626350410425 0.399288539267169 no 2023 0.406861312211558 2819 704353 SGTC_621 3584-0052 32.1 µM -0.238085514581729 0.398316574180336 no 2024 0.405907384717997 2886 2273927 SGTC_1704 st028805 70.8 µM -0.24000099181242 0.397559933529411 no 2025 0.405164743859277 2875 2876101 SGTC_1787 fluconazole 80 µM -0.240465872882507 0.397376356906452 no 2026 0.404984558333846 2879 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C SGTC_2275 7947463 200 µM -0.242690997250561 0.396497994235883 no 2027 0.404122391071932 2840 1225414 SGTC_641 4092-0595 30 µM -0.24372629602433 0.396089491145216 no 2028 0.403721403058076 2904 786260 SGTC_2629 bisabolol 100 µM -0.244840579846549 0.395649949995372 no 2029 0.403289935905103 2988 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer. SGTC_1925 st057770 10.1 µM -0.248836196676521 0.394074930898267 no 2030 0.401743745325995 2847 5989122 SGTC_2908 7930301 100 µM -0.249939836000008 0.393640194886591 no 2031 0.401316937992592 2850 2223178 SGTC_2771 fluoxetine 41.05 µM -0.251246405328215 0.393125693822624 no 2032 0.400811804320384 3041 3386 A selective serotonin reuptake inhibitor. SGTC_607 4491-0986 66.8 µM -0.251303546349473 0.393103197075605 no 2033 0.400789716768658 2993 698981 YDR232W HEM1 SGTC_1357 1503-1303 39.5 µM -0.2513202359547 0.39309662634989 no 2034 0.400783265552159 2859 292895 SGTC_2891 9063876 19.48 µM -0.255784083487986 0.391340301142484 no 2035 0.399058782353113 2967 6472478 SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM -0.256654987593624 0.390997896060113 no 2036 0.398722561217225 2901 4330530 SGTC_1790 st045711 43.5 µM -0.257101413914727 0.390822411603878 no 2037 0.398550243041568 3023 585119 SGTC_3046 9092212 49.47 µM -0.257278813930334 0.390752684105246 no 2038 0.398481773072178 2849 25236637 SGTC_904 1141-0088 396 µM -0.260178360414335 0.389613509883126 no 2039 0.397363097748087 2908 1378119 SGTC_1157 4092-0394 27.6 µM -0.260196056518701 0.38960656033516 no 2040 0.397356272987251 3043 3659885 SGTC_2363 9053361 176 µM -0.260520739334834 0.389479058380554 no 2041 0.397231059901694 3026 6469797 YMR079W SEC14 SGTC_1429 4049-0205 9.46 µM -0.261041846062027 0.389274446226617 no 2042 0.397030118589484 2867 22774478 SGTC_3138 9097216 49.47 µM -0.26334967520177 0.38836864864088 no 2043 0.396140537605812 2808 25237486 SGTC_1531 st059297 52.4 µM -0.263874266250899 0.388162836880836 no 2044 0.395938402800959 2985 7566702 SGTC_1276 0871-0068 94.2 µM -0.264082256755586 0.388081245071663 no 2045 0.395858267887544 2968 3414906 SGTC_97 0535-0701 19.132 µM -0.26505032874171 0.387701548829361 no 2046 0.395485345538228 2906 2832013 YGL099W LSG1 SGTC_1318 1280-3875 124 µM -0.265355846116448 0.387581741376353 no 2047 0.395367673458037 2939 373245 SGTC_21 0849-0113 22.993 µM -0.267364525569621 0.386794312549285 no 2048 0.394594255009286 2889 1560156 SGTC_1872 amphotericin b 148 nM -0.267498519907966 0.386741801538788 no 2049 0.394542676804039 3005 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1 SGTC_3196 9111891 49.47 µM -0.268469141619169 0.386361486783028 no 2050 0.394169112345607 2843 18891510 SGTC_207 4185-0010 4.486 µM -0.268530147469528 0.386337586750747 no 2051 0.394145636191099 2956 3761753 SGTC_1932 st074806 40.9 µM -0.268919311650616 0.386185135518134 no 2052 0.393995887831192 3119 17251235 SGTC_1900 st060200 72.8 µM -0.2692802929439 0.386043740361537 no 2053 0.393856998109685 2857 688945 SGTC_736 0958-0254 92.6 µM -0.269483210419556 0.385964264914077 no 2054 0.393778930317978 2996 6812352 SGTC_994 3910-0338 138 µM -0.269896309461403 0.385802483729236 no 2055 0.393620013238754 3068 3479481 SGTC_2380 9035439 200 µM -0.270315542560566 0.385638320580988 no 2056 0.393458754533194 3038 6462575 SGTC_2742 clothiapine 36.27 µM -0.270450843034504 0.385585344040038 no 2057 0.393406714881079 2946 16351 An atypical antipsychotic. YIL048W NEO1 SGTC_1016 4226-1401 38 µM -0.270816274982009 0.385442270802156 no 2058 0.393266170928201 2838 2901613 SGTC_2288 7946289 167.31 µM -0.271165301581751 0.385305635109453 no 2059 0.393131949404793 3081 1246052 SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM -0.271381031014665 0.385221189235641 no 2060 0.39304899493532 2862 91467 include heat shock SGTC_1128 3448-9350 235 µM -0.271701422106699 0.385095784285289 no 2061 0.392925803866375 2980 619386 SGTC_1369 1866-0067 208 µM -0.273156944269277 0.384526226776994 no 2062 0.392366287630991 3037 3531355 SGTC_2727 riluzole 51.77 µM -0.273304974413249 0.384468315332264 no 2063 0.392309395910774 2890 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.  SGTC_2873 9040596 71.43 µM -0.273330331000664 0.384458395742323 no 2064 0.392299650965161 3000 6463863 SGTC_2931 9014674 55.67 µM -0.276292683222038 0.383300035056125 no 2065 0.391161637612958 2897 2996810 SGTC_8 0354-0001 70 µM -0.27773465942924 0.382736559530008 no 2066 0.390608026256678 2917 4993152 SGTC_834 0312-0008 75.7 µM -0.279249878409457 0.382144730548856 no 2067 0.390026534000133 2893 6385573 YIL048W NEO1 SGTC_632 0781-2353 4.65 µM -0.279341677863627 0.382108883454128 no 2068 0.389991312216219 2990 6811515 YHR007C ERG11 SGTC_1701 st028638 40.4 µM -0.27952802772321 0.382036118144131 no 2069 0.389919815936289 3012 3490878 SGTC_3322 9139058 2.11 µM -0.280525540592421 0.381646683347991 no 2070 0.389537166607627 3089 4908926 YPR165W RHO1 SGTC_1824 st053723 68.6 µM -0.283117551953516 0.380635307949555 no 2071 0.388543363647538 2961 675225 SGTC_767 0929-0023 86 µM -0.284563339095748 0.380071530822588 no 2072 0.387989350801208 2927 1204563 SGTC_1395 3486-0190 4.35 µM -0.285199680037855 0.379823473665194 no 2073 0.387745582739549 3063 6748079 SGTC_2432 5630864 12.22 µM -0.285353559468316 0.379763496112024 no 2074 0.387686641590775 3043 5714970 SGTC_2626 ethyl orsellinate 100 µM -0.288523962241485 0.378528414547042 no 2075 0.386472845402821 2890 75653 A natural product. SGTC_947 3447-0010 211 µM -0.288904628883429 0.378380202833816 no 2076 0.386327180685277 2897 748350 SGTC_2129 girgensonine 121.053 µM -0.290179271746197 0.377884053826498 no 2077 0.385839546528972 2986 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_2990 9074105 71.4286 µM -0.290998579890172 0.377565248074471 no 2078 0.385526202808483 2980 6502001 SGTC_724 3910-0327 137 µM -0.292549508933475 0.376961985577833 no 2079 0.384933255972854 2989 2885483 SGTC_854 0422-0053 192 µM -0.293704463007199 0.376512939803439 no 2080 0.384491871833673 2939 3596728 SGTC_2024 5144227 134 µM -0.294667692407824 0.376138564250203 no 2081 0.384123872802561 3080 3475211 SGTC_2916 7875993 68.79 µM -0.295580910474832 0.375783734051038 no 2082 0.383775076895659 2970 1299250 SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM -0.296627878072154 0.375377064796624 no 2083 0.383375312332687 2971 688788 SGTC_1341 1486-1360 280 µM -0.296955105020459 0.375249989776338 no 2084 0.383250392420473 2905 3976547 SGTC_2068 5226020 147 µM -0.300481911411775 0.373881254777785 no 2085 0.381904795962884 2987 1810509 SGTC_144 4161-2749 112.381 µM -0.300631494174156 0.373823237497422 no 2086 0.381847756455809 2950 797501 YMR168C CEP3 SGTC_855 0428-0020 25 µM -0.301068251959415 0.373653852665204 no 2087 0.381681224884188 2956 6812414 SGTC_2488 5268135 45.7 µM -0.301938159275434 0.373316555099624 no 2088 0.381349602800208 3074 1270356 YLR208W SEC13 SGTC_3049 9092223 49.47 µM -0.302465870047674 0.373111987980792 no 2089 0.381148473742293 3036 8623917 SGTC_2389 9091542 195.52 µM -0.303056778366988 0.372882964777793 no 2090 0.380923295985346 2991 3626624 YOL127W RPL25 SGTC_2282 7944268 200 µM -0.303769062739212 0.372606958573342 no 2091 0.380651918990708 3137 2970414 SGTC_3260 9137109 49.47 µM -0.303844673013164 0.372577663853068 no 2092 0.380623115276832 3010 17478346 SGTC_3355 9151058 44.0485 µM -0.305255611524397 0.372031140074842 no 2093 0.380085740172096 2980 17015728 SGTC_1620 st003704 16.5 µM -0.306559711137222 0.371526229237335 no 2094 0.379589261868562 2973 2834414 SGTC_3195 9113082 49.47 µM -0.307090873805477 0.371320641210133 no 2095 0.379387101983677 3036 17018038 SGTC_1354 1498-1681 81 µM -0.30733854094076 0.371224793483589 no 2096 0.379292851432491 3035 5754243 SGTC_2630 antimycin a 100 µM -0.307448211800129 0.371182353170514 no 2097 0.379251118113968 2890 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain. SGTC_1627 st003713 25.6 µM -0.307565836769765 0.371136836525305 no 2098 0.379206359562486 3025 16195070 YER133W GLC7 SGTC_2292 7671323 168.05 µM -0.307573963556515 0.371133691816825 no 2099 0.379203267224431 3113 937504 SGTC_3130 9127414 49.47 µM -0.309392982986865 0.370430028298574 no 2100 0.378511303747134 2978 1494646 SGTC_2175 5807670 165.306 µM -0.309834969062745 0.370259117197574 no 2101 0.378343228894526 3081 241186 SGTC_2447 5741742 33.78 µM -0.310159131776033 0.370133783359105 no 2102 0.378219973575494 3043 1776504 SGTC_1868 st057644 42.7 µM -0.31064301475566 0.369946721147298 no 2103 0.378036011404382 2924 688665 SGTC_2336 9001819 198.65 µM -0.31128858839628 0.369697199557484 no 2104 0.377790620891165 3192 2989602 SGTC_2607 solasodine 47.35 µM -0.312313882483442 0.369301024461296 no 2105 0.377400995326723 2965 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity. SGTC_3259 9138485 49.47 µM -0.313762210556871 0.368741624965763 no 2106 0.376850823800204 3277 17646153 SGTC_2906 7926292 26.41 µM -0.316013223679615 0.367872750064706 no 2107 0.375996235519403 3088 2966319 SGTC_3161 9100388 49.47 µM -0.316361447542636 0.367738398388175 no 2108 0.375864087876529 2986 25236368 SGTC_96 0929-0093 37.281 µM -0.316649809429931 0.36762715489755 no 2109 0.375754668301838 2965 6991579 SGTC_496 calpeptin 138 µM -0.316764062739053 0.367583081627622 no 2110 0.375711317386509 3015 73364 A calpain inhibitor. SGTC_1366 1683-0113 21.9 µM -0.317069215985201 0.367465377163835 no 2111 0.375595541364258 2965 708623 SGTC_246 cycloheximide 667 µM -0.317577682597018 0.367269277827763 no 2112 0.375402652551237 2948 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells. SGTC_2929 9013348 24.6 µM -0.318705728342392 0.366834350251547 no 2113 0.374974835209688 3058 2995952 SGTC_2400 5203494 178.7 µM -0.319171997285052 0.366654626201862 no 2114 0.374798045126622 2938 6777674 SGTC_2894 9048625 32.47 µM -0.319944046982637 0.366357102799959 no 2115 0.374505373368144 3142 4092861 SGTC_155 k072-0202 43.6 µM -0.32004810949797 0.366317006553857 no 2116 0.374465930448722 2985 5857737 SGTC_133 0724-0033 378.92 µM -0.321217794427807 0.365866416659575 no 2117 0.374022674054111 2892 280309 SGTC_852 0418-0143 439 µM -0.322167387453597 0.365500747295257 no 2118 0.373662944730251 3076 5369229 SGTC_2377 9073351 62.6 µM -0.324184785968451 0.364724293270919 no 2119 0.37289906983975 2952 7337946 YHR072W ERG7 SGTC_3002 9075603 71.4286 µM -0.324363632929541 0.364655485571942 no 2120 0.372831374654511 2982 20105405 SGTC_1167 k781-0610 148 µM -0.324817463070147 0.364480903309167 no 2121 0.372659613489627 3012 4525169 SGTC_2486 5283202 22.39 µM -0.325052522237406 0.364390490301488 no 2122 0.372570660560106 3014 1377751 SGTC_1654 st012436 41.8 µM -0.325159807595826 0.364349226637192 no 2123 0.372530063053835 3058 4323132 SGTC_2574 2',4'-dihydroxychalcone 14.64 µM -0.325898425590768 0.364065185038675 no 2124 0.372250603461944 3045 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_2218 6965428 192.983 µM -0.326775956904053 0.363727820237448 no 2125 0.371918672800414 3058 675684 SGTC_1078 idebenone 36.1 µM -0.327376961054106 0.363496826563728 no 2126 0.371691394834435 3050 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen. SGTC_50 0929-0078 56.389 µM -0.327839392787313 0.363319126447842 no 2127 0.371516550363328 2971 1377751 SGTC_1374 2889-5571 141 µM -0.328625994466794 0.363016924095437 no 2128 0.371219198819433 3035 2853281 SGTC_2643 anethole 100 µM -0.329044362022426 0.362856227332073 no 2129 0.371061078613801 3040 637563 An anti-fungal, anti-helmenthic and channel blocker. SGTC_879 0831-1030 162 µM -0.329150578115809 0.362815433119849 no 2130 0.371020938164777 3002 1549252 SGTC_2988 9073640 71.4286 µM -0.329339025835459 0.362743060195579 no 2131 0.370949724763938 3193 9102229 SGTC_2462 5162487 171.77 µM -0.329391680771921 0.362722839061548 no 2132 0.370929827530619 2959 2259986 SGTC_3123 9126162 49.47 µM -0.330873080519957 0.362154092553033 no 2133 0.370370178203259 2959 25239884 SGTC_2801 7907800 81.82 µM -0.333704729193107 0.36106779898556 no 2134 0.369301190292033 3098 6620925 SGTC_2612 dictamnine 15.46 µM -0.334566716012044 0.360737340445864 no 2135 0.368975978031648 3064 68085 A quinoline derivative and established mutagen. YOR116C RPO31 SGTC_1249 0481-0015 10.2 µM -0.335827194074108 0.360254300146284 no 2136 0.368500591011748 2965 4227577 SGTC_1165 k072-0275 30.3 µM -0.336058524039989 0.360165674091513 no 2137 0.368413367163939 3125 6153523 YGL055W OLE1 SGTC_2342 7990637 118.86 µM -0.338453794946751 0.359248451635973 no 2138 0.367510620456142 3115 2033102 YER133W GLC7 SGTC_756 0508-1999 28.3 µM -0.340579687374614 0.358435061160677 no 2139 0.366710011646194 3007 6753853 SGTC_2310 7668677 200 µM -0.341461942144016 0.358097688757345 no 2140 0.366377925401426 3230 2197143 SGTC_2072 5231554 129 µM -0.341771692716121 0.357979267037924 no 2141 0.366261357050314 3128 789545 SGTC_1767 st044992 70.3 µM -0.341815004758977 0.357962709362731 no 2142 0.366245058423782 3051 9600693 SGTC_1968 st069590 43.6 µM -0.342503122891143 0.357699685906232 no 2143 0.365986147115543 3133 6384066 SGTC_2880 9042983 58.44 µM -0.34338026897662 0.357364507136975 no 2144 0.365656200626237 3134 6464714 SGTC_535 2293-4129 48.2 µM -0.343583675839257 0.357286796151109 no 2145 0.36557970146663 3173 396118 YIL048W NEO1 SGTC_15 0266-0086 27.098 µM -0.345718184733384 0.35647167087209 no 2146 0.364777258293125 3112 1712902 YIL048W NEO1 SGTC_2219 9098279 200 µM -0.345870690302344 0.356413457150747 no 2147 0.364719948261374 3098 902349 SGTC_544 k015-0020 52.4 µM -0.346584981121128 0.356140845908002 no 2148 0.364451565337912 3066 3008304 SGTC_1812 st052057 4.327 µM -0.347035448305237 0.355968961542589 no 2149 0.364282343919085 2994 3645418 SGTC_1438 4092-1045 4 µM -0.347414069479808 0.35582451403402 no 2150 0.364140132458242 3017 1351342 SGTC_27 0485-0001 32.618 µM -0.347429235746925 0.355818728392694 no 2151 0.364134436343846 3027 2054479 SGTC_2112 5488546 200 µM -0.348298230561617 0.355487278966509 no 2152 0.363808111281288 2989 600757 SGTC_1565 sinapyl alcohol 95.1 µM -0.34869733562651 0.355335090093556 no 2153 0.363658272367147 3109 5280507 A phenol propionate derived from cinnamic acid. SGTC_1690 st023502 41.2 µM -0.348782940166533 0.355302449917294 no 2154 0.363626135947867 3113 24207482 SGTC_1355 1499-0035 1.68 µM -0.350359593892312 0.354701477259343 no 2155 0.363034423181293 3019 1548538 SGTC_2739 tacrine 100.86 µM -0.352559333609848 0.353863607265506 no 2156 0.362209414643693 3117 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders. SGTC_56 0957-0365 83.25 µM -0.352973447750713 0.353705952220085 no 2157 0.36205417328856 3153 6752360 SGTC_2454 5-benzylidenerhodanine 10.36 µM -0.353301484967018 0.353581084838138 no 2158 0.361931216191014 3188 1273210 SGTC_226 1,3-diallylurea 8.28947 mM -0.353492355020761 0.353508437392329 no 2159 0.361859679561204 3105 74537 YKL182W FAS1 SGTC_1910 st062352 60.4 µM -0.355327490204058 0.352810235422123 no 2160 0.361172131609788 2961 2245730 SGTC_3335 9143315 29.6265 µM -0.355557041538512 0.352722934330096 no 2161 0.361086159877601 3034 4899691 SGTC_1557 sumaresinolic acid 42.3 µM -0.355970249337478 0.352565806055407 no 2162 0.360931422678776 3026 9982268 A natural terpine and antifungal of unknown mechanisn. SGTC_1523 st012844 44.7 µM -0.356250610254759 0.352459209060361 no 2163 0.360826446662436 3148 4274103 SGTC_3137 9097352 49.47 µM -0.356407146934437 0.35239969674758 no 2164 0.360767838927199 3323 44120435 SGTC_592 k241-0073 46.5 µM -0.356657795045004 0.352304412557537 no 2165 0.360674002440102 3165 4230158 SGTC_3179 9107801 49.47 µM -0.357113069098116 0.352131363275357 no 2166 0.360503580492665 3026 4818259 SGTC_2071 5230951 39.92 µM -0.358996490078911 0.351415802207927 no 2167 0.35979885750647 3125 1799272 SGTC_933 2914-0560 114 µM -0.359470169738234 0.35123592159642 no 2168 0.359621694821422 3212 463887 SGTC_1759 st043059 70 µM -0.36024240208957 0.350942736577578 no 2169 0.359332934025422 3013 669426 SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM -0.360806058989914 0.350728795121893 no 2170 0.359122216534967 3054 115019 SGTC_1987 st072290 61.9 µM -0.361153971015653 0.350596765347493 no 2171 0.358992174489477 3085 54697379 SGTC_2156 5649887 115 µM -0.362152396377743 0.350217971316036 no 2172 0.358619075296173 3143 54680440 YKL052C | YBR257W ASK1 | POP4 SGTC_2714 st079313 56.9 µM -0.363084622978294 0.34986442698005 no 2173 0.358270835517273 3046 2939799 SGTC_2639 lactacystin 53 µM -0.363625659978991 0.34965929986467 no 2174 0.358068781384313 3197 3870 A proteasome inhibitor. SGTC_1224 0823-0416 294 µM -0.36450110939938 0.349327477620772 no 2175 0.357741922757712 3178 3598164 SGTC_293 4049-0273 38.5 µM -0.364858965010632 0.349191872476969 no 2176 0.357608343461326 3081 1380311 SGTC_2114 5491910 81.25 µM -0.365685378546025 0.348878786449223 no 2177 0.357299928899222 3175 2849228 SGTC_2994 9053520 71.4286 µM -0.366485349682929 0.348575816074368 no 2178 0.357001471309445 3167 4647384 SGTC_2596 sinensetin 100 µM -0.370429884480516 0.347083330830655 no 2179 0.355531105199708 3088 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets. SGTC_2043 5101342 149 µM -0.372043987419398 0.346473287767154 no 2180 0.354930049524761 3078 678451 SGTC_3235 9132602 49.47 µM -0.372877042307449 0.34615859396292 no 2181 0.354619979686649 3176 4912240 SGTC_489 paxilline 115 µM -0.372944183127718 0.34613323554983 no 2182 0.354594993515623 3133 105008 A toxic potassium channel blocker. SGTC_1430 4049-0248 69.1 µM -0.373662776263788 0.345861873370552 no 2183 0.354327611333908 3171 22774488 SGTC_1069 diphenylcyclopropenone 8.49 µM -0.374255076872774 0.345638262515441 no 2184 0.354107275454584 3087 65057 A dermal irritant. YDR527W RBA50 SGTC_842 0271-0008 11.1 µM -0.374321506490608 0.345613186742836 no 2185 0.354082566675407 3196 1221709 SGTC_1089 terbinafine 2.25 µM -0.375042010533277 0.345341255277653 no 2186 0.353814611619538 3165 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_88 0180-0332 8.668 µM -0.376277870825264 0.344875004824148 no 2187 0.353355164516852 3048 3101745 SGTC_3043 9092303 49.47 µM -0.376578831205917 0.344761497750652 no 2188 0.353243310909157 3119 25236084 SGTC_2048 5246248 200 µM -0.377587868877105 0.344381041644531 no 2189 0.352868388963724 3194 677046 SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM -0.378141528918339 0.344172351829522 no 2190 0.352662729554972 3077 4174840 SGTC_2594 a-mangostin 100 µM -0.378458047165629 0.344053068640252 no 2191 0.352545176825816 3201 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis. SGTC_648 0375-0473 33.3 µM -0.378855389956086 0.343903347849116 no 2192 0.352397626344113 3073 1713139 SGTC_2566 crystal violet carbinol 226 nM -0.379276954535919 0.343744526921147 no 2193 0.35224110555186 3196 68050 Cationic dye that binds acidic phospholipids including cardiolipin. SGTC_3310 9130229 44.1445 µM -0.379280070054476 0.343743353278209 no 2194 0.352239948898291 3197 7761258 SGTC_309 k408-0051 1.48 µM -0.379726224670702 0.343575298508244 no 2195 0.352074325635916 3127 3640463 SGTC_2346 9031566 143.75 µM -0.380881278704274 0.343140363560071 no 2196 0.351645672371082 3126 4771086 SGTC_2779 methotrexate 400 µM -0.381314964423072 0.342977113051667 no 2197 0.351484775486315 3175 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2 SGTC_704 1310-0270 142 µM -0.382467703991411 0.34254333465069 no 2198 0.351057239892367 3116 5718033 SGTC_2406 ethylparaben 405.7 µM -0.385789748024265 0.341294405059569 no 2199 0.349826194277352 2968 8434 A possible steroid mimic. SGTC_519 k048-0011 62.8 µM -0.386443046795778 0.341048999859166 no 2200 0.349584287344572 3173 6836379 SGTC_2049 5262831 67.185 µM -0.387489584684348 0.340656018425772 no 2201 0.349196897045517 3153 763417 SGTC_3093 9117344 49.47 µM -0.388760069530751 0.340179175902935 no 2202 0.348726820828989 3213 24824913 SGTC_1899 st063254 59.6 µM -0.388945088076439 0.340109755432456 no 2203 0.348658383777351 3052 3093813 SGTC_1830 st055982 50.3 µM -0.389612874362311 0.339859241658553 no 2204 0.348411415331361 3200 455313 An antimicrobial agent. SGTC_2575 plumbagin 510 nM -0.390123550648678 0.339667713932716 no 2205 0.348222594469452 3038 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_2469 5655019 90.81 µM -0.390230816883021 0.339627489287458 no 2206 0.348182937914113 3213 2788239 SGTC_1306 1185-0270 9.02 µM -0.390874351761485 0.339386203228549 no 2207 0.34794505656449 3200 1548076 SGTC_795 0685-0265 78 µM -0.390890176762148 0.339380270654095 no 2208 0.347939207638783 3091 302754 SGTC_2774 tamoxifen 10.92 µM -0.391819231222461 0.339032050768229 no 2209 0.347595892243729 3135 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  SGTC_2489 cantharidin 73.42 µM -0.392063816641018 0.338940400296811 no 2210 0.347505530861025 3098 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_1631 benzylvanillin 81.9 µM -0.392385997722377 0.338819687910588 no 2211 0.347386515207561 3213 75506 SGTC_150 3970-0969 77.2 µM -0.396684696262773 0.33721067174801 no 2212 0.345799993430315 3211 6615640 SGTC_1691 st019933 84.6 µM -0.396699338420159 0.337205196207713 no 2213 0.345794594050766 3184 6176082 SGTC_2126 5251174 33.877 µM -0.397522688302 0.336897354103329 no 2214 0.345491029551926 3279 790722 SGTC_2461 5755302 26.15 µM -0.399397651702425 0.33619673229068 no 2215 0.344800111993875 3240 2788904 SGTC_2318 6029776 164 µM -0.400028328705949 0.335961193458766 no 2216 0.344567825832271 3282 818325 SGTC_814 3342-0569 96 µM -0.400156840469867 0.335913206088537 no 2217 0.344520500539842 3186 4346283 SGTC_2687 chenodiol 100 µM -0.404241629283717 0.334389309028227 no 2218 0.343017522047602 3220 5702181 A cholesterol synthesis inhibitor. SGTC_1417 3966-0327 90.4 µM -0.405203808721714 0.334030747914498 no 2219 0.34266385279767 3172 651118 SGTC_104 0074-0074 590.992 µM -0.405305948065975 0.333992694048806 no 2220 0.342626317426884 3109 3943124 SGTC_969 1313-0238 134 µM -0.405432438301926 0.333945570182387 no 2221 0.342579835456957 3112 5212874 SGTC_2764 methyldopa 94.69 µM -0.405963599069605 0.333747715126407 no 2222 0.342384673306233 3291 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent. SGTC_2843 9000894 45.46 µM -0.406866433774549 0.333411519227821 no 2223 0.342053045146211 3165 2242070 SGTC_1863 st057641 20.1 µM -0.407455409694213 0.33319226955588 no 2224 0.341836768848564 3194 3921635 SGTC_355 1311-2252 105 µM -0.407557635390575 0.333154221255188 no 2225 0.341799236103196 3140 5338538 SGTC_564 3555-0129 330 µM -0.408234712062378 0.332902257371767 no 2226 0.341550683047788 3174 563260 SGTC_380 3970-0968 6 µM -0.408795700014571 0.332693551291248 no 2227 0.341344797885488 3089 2891601 SGTC_1137 ixabepilone 100 µM -0.40886705107036 0.332667010052249 no 2228 0.341318615102394 3131 154225 A novel microtubule stabilizer. SGTC_1203 3992-3522 103 µM -0.41082788161731 0.331937946911206 no 2229 0.340599373539759 3420 5322312 SGTC_1329 1447-1697 50.6 µM -0.411480834335927 0.331695311307549 no 2230 0.340359995940298 3205 2840515 SGTC_1945 st075991 56.6 µM -0.411527728728556 0.331677888183856 no 2231 0.340342806561385 3150 1084980 SGTC_2025 5147754 141 µM -0.413767143241477 0.330846281494826 no 2232 0.339522324479105 3160 315777 YLR208W SEC13 SGTC_3184 9108758 49.47 µM -0.413905620850567 0.33079488516929 no 2233 0.33947161363193 3117 902885 SGTC_1762 st045503 25.4615 µM -0.41778106551709 0.329357800510145 no 2234 0.338053597910556 3205 4645554 SGTC_589 1227-0070 34.1 µM -0.418084056970361 0.329245551646151 no 2235 0.337942830539172 3252 2841384 SGTC_1061 3448-9325 110 µM -0.42005951541349 0.328514083694537 no 2236 0.337220988360963 3220 723482 SGTC_986 1493-0483 84 µM -0.42024252432338 0.32844635279537 no 2237 0.337154146278079 3252 40079 SGTC_504 lovastatin 124 µM -0.421874941463748 0.327842451063697 no 2238 0.336558150698184 3177 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1 SGTC_828 2074-0507 139 µM -0.421907735712886 0.327830323657053 no 2239 0.336546181716007 3273 X828 SGTC_493 zm226600 134 µM -0.425201395996308 0.326613245429439 no 2240 0.335344933308919 3310 5240098 A potassium channel opener. YCR052W RSC6 SGTC_1098 clofazimine 15.1 µM -0.425586844789055 0.326470934041045 no 2241 0.335204463900172 3264 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2 SGTC_3347 9188721 44.724 µM -0.426730694277192 0.326048762578447 no 2242 0.334787745634853 3221 44118411 YKL104C | YBL026W GFA1 | LSM2 SGTC_93 0109-0045 59.227 µM -0.427342686275274 0.325822980324283 no 2243 0.334564872993343 3244 88733 SGTC_3315 9136395 68.55 µM -0.427582093510716 0.325734673168609 no 2244 0.334477702540203 3341 16876844 SGTC_992 3909-8734 162 µM -0.428132459909322 0.325531703472172 no 2245 0.334277342736738 3184 4288319 SGTC_2366 9070441 60.58 µM -0.428160142340118 0.325521495830637 no 2246 0.334267266248792 3153 6837235 SGTC_910 3454-3003 490 µM -0.428563178230125 0.325372894881298 no 2247 0.3341205735051 3279 820824 SGTC_547 1120-0019 610 nM -0.428854340633422 0.325265559404251 no 2248 0.334014615052345 3153 3676939 SGTC_1081 sertraline 6 µM -0.429312869551704 0.325096554538191 no 2249 0.333847776189949 3261 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1 SGTC_1484 3473-2379 286 µM -0.42935498601341 0.32508103303084 no 2250 0.333832453475459 3288 671917 SGTC_1029 k015-0030 64.7 µM -0.430101467240028 0.324805976886705 no 2251 0.333560916385418 3255 2208316 SGTC_3272 9137413 49.47 µM -0.43113888810536 0.324423876723583 no 2252 0.33318369300372 3160 17614870 SGTC_1223 0764-0573 147 µM -0.431463406718516 0.324304388791593 no 2253 0.333065727290378 3172 1609797 SGTC_429 1112-0049 25.5 µM -0.431708165746139 0.324214280349556 no 2254 0.332976765897732 3099 2836170 SGTC_3155 9099265 49.47 µM -0.431726700690904 0.324207457098164 no 2255 0.332970029472843 3250 25236499 SGTC_2401 5128683 200 µM -0.431738278821557 0.32420319488202 no 2256 0.332965821491567 3154 708373 SGTC_3098 9119039 49.47 µM -0.432289763855241 0.324000205345387 no 2257 0.33276541292813 3242 17161528 SGTC_3067 9117431 49.47 µM -0.43374712311622 0.323464035338044 no 2258 0.332236041530559 3180 17150885 SGTC_3167 9103034 49.47 µM -0.435283096744525 0.322899339202805 no 2259 0.331678476333908 3248 5127859 SGTC_2998 9066762 71.4286 µM -0.435804526091139 0.322707729963467 no 2260 0.331489279856904 3350 4945196 SGTC_901 1112-0062 60.1 µM -0.436240862050245 0.32254742609319 no 2261 0.331330991872423 3183 1908457 SGTC_319 1348-1596 45.5 µM -0.437797632057386 0.321975758986687 no 2262 0.330766493827905 3324 5380505 SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM -0.43919182671767 0.321464149047617 no 2263 0.330261273407235 3126 6708514 SGTC_3105 9121040 49.47 µM -0.440212036556148 0.321089989981252 no 2264 0.329891771409638 3222 41448907 SGTC_175 3793-3120 23.7 µM -0.440306412982924 0.321055386863626 no 2265 0.329857598312552 3168 5322297 SGTC_1461 k072-0203 53.8 µM -0.441216359508227 0.320721834717926 no 2266 0.329528185414368 3210 5418714 SGTC_1158 4092-0494 91.8 µM -0.443291907424151 0.319961558709162 no 2267 0.328777304239426 3311 1148199 SGTC_183 3914-0051 30.55 µM -0.444653973147563 0.319463042558313 no 2268 0.328284918142051 3303 1596232 SGTC_2368 9071271 200 µM -0.44565960059184 0.319095192049939 no 2269 0.327921575575446 3213 27209959 SGTC_2387 9077560 195.08 µM -0.446223734042717 0.318888914465724 no 2270 0.327717820164331 3181 5303272 SGTC_2230 bromochlorosalicylanilide 954.5 nM -0.446482736872607 0.318794227859279 no 2271 0.327624289920538 3235 77254 SGTC_1874 staurosporine 7.6 µM -0.447228937927811 0.318521496805882 no 2272 0.327354884750856 3277 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1 SGTC_1474 0330-0125 5.35 µM -0.447475032856145 0.318431572449692 no 2273 0.327266055418534 3293 X1474 SGTC_512 prima-1 270 µM -0.44860215245604 0.318019853875536 no 2274 0.326859340389844 3331 322968 A re-activator of the apoptotic function of mutant p53. SGTC_3061 glucosamine 200 µM -0.44872543761635 0.317974833429601 no 2275 0.326814866071158 3298 91431 and experimental redox chemotherapeutic SGTC_2951 9072950 58.06 µM -0.448865174915163 0.317923808354708 no 2276 0.326764459725376 3282 16488155 SGTC_1114 scopoletin 1.73284 µM -0.449483785583733 0.317697964201141 no 2277 0.326541351113061 3297 5280460 A coumarin with genotoxic properties. SGTC_1108 betulinic acid 729.144 nM -0.452977239716593 0.31642383879646 no 2278 0.325282565390937 3238 64945 Apoptosis-inducing agent of unknown mechanism. SGTC_1989 st071868 50.2 µM -0.45393776360292 0.316073899228766 no 2279 0.324936811081708 3308 16414057 SGTC_120 rhodamine 6G 52.259 µM -0.455582868557763 0.315474934771789 no 2280 0.324344982302755 3169 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase SGTC_2431 5490079 200 µM -0.456029119891102 0.315312543088058 no 2281 0.324184519167548 3250 5722345 SGTC_1661 st013063 9.66 µM -0.456278249599059 0.315221899842491 no 2282 0.324094951262877 3225 721395 SGTC_896 0964-0007 44.5 µM -0.456416554577033 0.315171583819949 no 2283 0.324045231811988 3301 6756758 SGTC_1207 2099-0101 141 µM -0.456856538052657 0.315011538502498 no 2284 0.323887082410782 3298 5837381 SGTC_1716 st033144 30.6155 µM -0.457431925332435 0.314802292045029 no 2285 0.323680310899016 3377 674617 SGTC_1236 0330-0013 258 µM -0.458557612440955 0.314393094435713 no 2286 0.323275940732489 3206 4617066 SGTC_1149 3909-7961 23.3 µM -0.459511786284283 0.314046421941941 no 2287 0.322933345082142 3242 735261 SGTC_1617 st002906 78 µM -0.459553772062568 0.314031171344169 no 2288 0.322918273556751 3228 5150859 SGTC_2885 9057732 51.95 µM -0.459634893214139 0.314001706407892 no 2289 0.322889154532151 3350 6471414 SGTC_1295 1013-0063 9.78 µM -0.459637318494361 0.314000825512527 no 2290 0.322888283976972 3339 6826038 SGTC_997 3996-0078 137 µM -0.46080061991426 0.313578420578635 no 2291 0.322470828471061 3243 735687 SGTC_2194 5927483 104.545 µM -0.462436825935358 0.312984713405588 no 2292 0.321884047923703 3206 760979 SGTC_192 3455-0609 60.9 µM -0.465712511923458 0.311797568505372 no 2293 0.3207106476204 3347 3769639 SGTC_2846 9008642 19.48 µM -0.466103456379449 0.311656016110718 no 2294 0.320570724682069 3317 2992898 SGTC_2583 asiatic acid 100 µM -0.467015763638481 0.311325797966685 no 2295 0.320244299965507 3391 5320556 A kinase inhibitor; arrests cells at G2/M. SGTC_619 1652-1634 108 µM -0.468284587912401 0.310866787490546 no 2296 0.319790544217614 3227 5400454 SGTC_2498 4'-Methoxychalcone 54.63 µM -0.469716476720013 0.310349139979549 no 2297 0.319278797225595 3214 641818 YHR062C RPP1 SGTC_2028 5153890 36.43 µM -0.47050818865065 0.310063086334452 no 2298 0.318995992612675 3257 2830968 YPR165W RHO1 SGTC_353 1988-1175 58.3 µM -0.47223488306273 0.309439612712821 no 2299 0.318379571765956 3141 2788357 SGTC_230 MPP+ 141.667 µM -0.472451407380363 0.309361468903005 no 2300 0.318302309143136 3278 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death. SGTC_2268 7933382 153.85 µM -0.473259653314328 0.309069848433707 no 2301 0.318013971647094 3316 935025 YOR257W CDC31 SGTC_2501 sodium tetradecyl sulfate 13.37 µM -0.473656123304074 0.308926843402699 no 2302 0.317872573361904 3194 23665772 A membrane-active detergent. SGTC_1765 st044815 90.4 µM -0.474317863880757 0.308688220914863 no 2303 0.317636627302132 3291 645695 SGTC_840 0245-0196 390 µM -0.474318680891547 0.308687926352104 no 2304 0.317636336039651 3376 3827528 SGTC_1419 3993-2473 62.6 µM -0.474908697454659 0.308475235602154 no 2305 0.317426025964894 3285 704026 SGTC_1505 k297-0037 20.6 µM -0.475161676760061 0.308384060623049 no 2306 0.317335870105933 3222 4089396 SGTC_2664 lyso-paf C-16 73.48 µM -0.475295192269289 0.308335945744352 no 2307 0.317288292695454 3226 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_3064 1327-0027 10 µM -0.475418367067358 0.30829156025924 no 2308 0.317244402809671 3267 16000455 YPR107C YTH1 SGTC_2946 9065502 71.43 µM -0.47592403869011 0.308109373137157 no 2309 0.317064247843505 3236 16489101 SGTC_1153 4055-0057 267 µM -0.477238612313076 0.307635970070595 no 2310 0.316596109348245 3229 882706 SGTC_3031 9088762 49.47 µM -0.478465248103969 0.30719452378556 no 2311 0.316159551560006 3193 205253 SGTC_702 1488-0190 94 µM -0.479698283028583 0.3067510559773 no 2312 0.315720974480368 3333 949357 SGTC_1319 1306-0155 43.7 µM -0.479878884836664 0.30668612526292 no 2313 0.315656758148066 3277 3122360 SGTC_2694 st077685 81.9 µM -0.480327947152897 0.306524702805287 no 2314 0.315497109814294 3176 2838096 SGTC_64 000l-0018 272.079 µM -0.48088573667473 0.306324248918715 no 2315 0.31529885529052 3266 6811119 SGTC_914 3820-6779 408 µM -0.480920414445139 0.306311788614981 no 2316 0.315286531563353 3211 2893481 SGTC_194 1486-1323 56.904 µM -0.480931212699531 0.30630790866705 no 2317 0.315282694140004 3279 5178754 SGTC_723 4182-0001 115 µM -0.481927570559623 0.305949998327156 no 2318 0.314928699845498 3254 744821 YLR208W SEC13 SGTC_2070 5230947 200 µM -0.482367694024245 0.305791956719327 no 2319 0.314772383223285 3367 2835538 SGTC_1821 st053465 65.6 µM -0.482423197438883 0.305772028858755 no 2320 0.31475267268704 3286 675086 SGTC_2348 9022543 33.42 µM -0.482895135087592 0.305602608331908 no 2321 0.314585098124627 3336 3162678 YDL140C RPO21 SGTC_2053 5265679 138 µM -0.483167550809635 0.305504832964637 no 2322 0.314488386741188 3220 764595 SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM -0.483200432856823 0.305493031888368 no 2323 0.31447671401632 3337 66535 A nucleotide analog. SGTC_1820 st053765 18.6 µM -0.483234211144303 0.305480909369801 no 2324 0.314464723330215 3311 3690829 SGTC_3077 9117319 49.47 µM -0.486523528228437 0.304301446233526 no 2325 0.313298013900901 3335 17154678 SGTC_297 0986-0032 24 µM -0.488281447543262 0.303671934961132 no 2326 0.312675250322891 3266 2847425 SGTC_825 1988-2224 89.6 µM -0.488472307569337 0.303603622940973 no 2327 0.312607668044819 3252 1180859 SGTC_1761 st044296 37 µM -0.488496929364706 0.303594810885088 no 2328 0.312598950088034 3238 1826700 SGTC_89 0302-0250 142.109 µM -0.489130996974844 0.303367919617865 no 2329 0.312374478869128 3368 4203518 YLR208W SEC13 SGTC_672 1441-0018 53.7 µM -0.489238928574163 0.303329305515977 no 2330 0.31233627609289 3239 251141 SGTC_551 k048-0028 34.9 µM -0.489857383881587 0.303108086490228 no 2331 0.312117410527285 3379 6836383 SGTC_279 1273-0055 2.93 µM -0.491578313899496 0.302492896758994 no 2332 0.311508738547679 3334 2847562 SGTC_2499 avocadenofuran 51.48 µM -0.493900005413302 0.301663837978336 no 2333 0.310688400378423 3225 6857792 A insecticide and lysyl oxidase inhibitor. SGTC_176 1486-1328 72.834 µM -0.494317216859127 0.301514963250057 no 2334 0.310541083933573 3329 22310231 SGTC_3113 9123498 49.47 µM -0.494320985312893 0.301513618692811 no 2335 0.310539753439235 3365 8897275 SGTC_3017 9080681 49.47 µM -0.494474830913457 0.301458729990587 no 2336 0.310485438662245 3322 16451914 SGTC_87 0100-0052 35.5 µM -0.495159829117388 0.30121439241219 no 2337 0.310243652049115 3394 200187 YGR083C | YDR527W GCD2 | RBA50 SGTC_3231 9132313 49.47 µM -0.495813959048616 0.300981148793499 no 2338 0.310012837671919 3316 4905967 SGTC_2407 paclitaxel 400 µM -0.496305480692888 0.300805940137281 no 2339 0.309839450026608 3406 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_1509 1326-1131 80 µM -0.497182633296471 0.300493383183025 no 2340 0.309530133504141 3355 768313 SGTC_1390 3413-2614 145 µM -0.497304917202851 0.300449821248274 no 2341 0.309487022373167 3322 3421432 SGTC_1315 1237-0019 3.69 µM -0.497347531378444 0.300434641213353 no 2342 0.309471999382508 3366 825140 SGTC_3040 9091894 49.47 µM -0.497620077543657 0.300337562928642 no 2343 0.3093759248366 3268 25236966 SGTC_367 0335-0881 7.1 µM -0.498148811917319 0.30014927334162 no 2344 0.309189579206732 3394 23828853 SGTC_1227 3909-8010 46.6 µM -0.499353997298468 0.299720289887149 no 2345 0.308765010597255 3271 15982272 SGTC_2807 7945238 51.95 µM -0.499369824992849 0.299714657897183 no 2346 0.308759436437875 3337 17148797 SGTC_2066 5222451 176 µM -0.499376643900495 0.299712231530798 no 2347 0.308757034984942 3295 2281147 SGTC_1075 aripiprazole 15.2 µM -0.500705239876323 0.299239648153211 no 2348 0.308289292010005 3295 60795 An atypical antipschotic. YIL048W NEO1 SGTC_629 3448-6466 76.7 µM -0.501606827658782 0.298919144858547 no 2349 0.307972057852622 3353 573744 SGTC_2985 9022375 71.43 µM -0.505286937847411 0.297612531580081 no 2350 0.306678657919996 3450 4939335 SGTC_500 h-89 112 µM -0.505437337300437 0.297559188141356 no 2351 0.306625850020259 3432 449241 Protein kinase A inhibitor; also known to inhibit several other kinases. SGTC_1837 st055472 66.5 µM -0.506381786510656 0.297224312205128 no 2352 0.306294329036193 3449 676091 SGTC_835 0312-0010 67.2 µM -0.506622318764244 0.297139053555325 no 2353 0.306209922613966 3282 1626196 SGTC_2340 7987427 183.45 µM -0.508690559634626 0.296406410322683 no 2354 0.305484570284671 3366 2239331 SGTC_1901 st060216 58.6 µM -0.509046158618217 0.296280528200439 no 2355 0.305359935018078 3292 688792 SGTC_2969 9091408 28.7 µM -0.509549347766911 0.296102441031067 no 2356 0.305183608851554 3238 4286311 SGTC_3216 9129716 49.47 µM -0.510479858915858 0.295773246837093 no 2357 0.304857660789449 3286 8056934 SGTC_13 0199-0087 65 µM -0.510948348054967 0.295607569441253 no 2358 0.304693612647793 3385 4589825 SGTC_1021 4476-0760 85.3 µM -0.511328480642112 0.295473169985806 no 2359 0.304560532664124 3282 746768 SGTC_2918 7977171 22.06 µM -0.511782630674101 0.295312637820964 no 2360 0.304401573947032 3335 2236483 SGTC_1173 0443-0020 122 µM -0.514126502737986 0.294484768833995 no 2361 0.303581774549379 3300 5331295 SGTC_3099 9120367 49.47 µM -0.514316801929897 0.294417601113157 no 2362 0.30351525824876 3385 24824940 SGTC_1105 epirubicin 18.1 µM -0.514434388188891 0.294376101576902 no 2363 0.303474160944757 3288 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_1895 st058434 18.3 µM -0.514976363868758 0.29418485786228 no 2364 0.303284768408044 3435 5393175 SGTC_3027 9089541 49.47 µM -0.515412605229344 0.294030965694635 no 2365 0.30313236295069 3396 9943819 SGTC_2019 4016004 108 µM -0.516409810874168 0.293679322893065 no 2366 0.302784107500973 3338 45595336 SGTC_1734 st037168 69.4 µM -0.516910145568168 0.293502964148729 no 2367 0.302609442483252 3342 708907 SGTC_1752 st044819 83.042 µM -0.517177996384211 0.293408571842333 no 2368 0.302515955300138 3278 441209 YML126C ERG13 SGTC_2123 5259487 200 µM -0.517199232625661 0.293401088659522 no 2369 0.302508543831178 3390 2173474 SGTC_66 0109-0187 42.4 µM -0.517652637112273 0.293241340026933 no 2370 0.302350324649901 3424 759417 SGTC_2766 oltipraz 83.91 µM -0.518993756168911 0.292769057864122 no 2371 0.301882547687982 3414 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40 SGTC_598 3937-0236 20.2 µM -0.519769230041134 0.292496131898923 no 2372 0.301612213974591 3383 1379313 SGTC_3069 9117009 49.47 µM -0.519999005242397 0.292415285844783 no 2373 0.301532134212632 3290 41904981 SGTC_491 tetrandrine 80.3 µM -0.520437939437329 0.292260876402767 no 2374 0.301379186313378 3381 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_2220 6782180 200 µM -0.521695333322858 0.291818757106932 no 2375 0.300941237205232 3354 833803 SGTC_863 0466-0191 129 µM -0.52187994640083 0.291753870511694 no 2376 0.30087696081003 3403 765160 YPR165W RHO1 SGTC_1537 2',6'-dihydroxyflavanone 78 µM -0.522039265531034 0.291697879472607 no 2377 0.300821495939897 3318 5106787 A p450 inhibitor. SGTC_1047 2043-3044 82 µM -0.522082263099075 0.291682769286059 no 2378 0.300806527689722 3314 669592 SGTC_2351 9026858 72.31 µM -0.523098741364813 0.29132566524392 no 2379 0.30045277067783 3282 1409300 SGTC_1451 4152-0210 104 µM -0.526169717005067 0.290248026783314 no 2380 0.299385146319752 3438 659563 SGTC_676 falcarinol 140 µM -0.527029278162538 0.289946732315871 no 2381 0.299086628417189 3478 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer. SGTC_3301 9125354 19.7965 µM -0.527787961228796 0.289680919677257 no 2382 0.298823256900571 3404 41905162 SGTC_3060 1327-0027 12.5 µM -0.528247087407675 0.289520115533175 no 2383 0.298663925664777 3344 16000455 YPR107C YTH1 SGTC_1181 1222-0449 220 µM -0.528359324568947 0.289480812017965 no 2384 0.298624981713271 3470 658318 SGTC_2362 9071156 126 µM -0.528410823751022 0.289462778732701 no 2385 0.298607113345268 3435 653133 SGTC_1544 7-methoxy-4-methylcoumarin 105 µM -0.528656425672465 0.289376784441563 no 2386 0.298521904982083 3313 390807 SGTC_1080 nisoldipine 24.4 µM -0.528747425504731 0.28934492509183 no 2387 0.298490336593242 3283 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class. SGTC_2010 4012422 159 µM -0.528826183637397 0.289317352933198 no 2388 0.298463016149729 3335 952393 SGTC_2713 st079149 53.4 µM -0.529074636540062 0.289230381019424 no 2389 0.298376837669443 3386 3103253 SGTC_336 4111-0029 111 µM -0.529456779703663 0.289096634298887 no 2390 0.298244309439389 3353 3131175 SGTC_140 0062-0056 502.533 µM -0.529490565642902 0.289084810919166 no 2391 0.298232593678746 3309 3758964 SGTC_787 4152-0075 138 µM -0.529510301680686 0.289077904403644 no 2392 0.298225750020597 3359 9566539 SGTC_1337 1486-1011 40.3 µM -0.529664150283151 0.28902406861024 no 2393 0.298172404011489 3414 X1337 SGTC_2775 cyproheptadine 69.59 µM -0.531692556505222 0.288314715723966 no 2394 0.297469474064871 3455 2913 A selective serotonin reuptake inhibitor. SGTC_967 1306-0166 352 µM -0.531828379097048 0.288267246616458 no 2395 0.297422432741739 3424 4437607 SGTC_2852 9023854 51.95 µM -0.531926965001219 0.288232793796587 no 2396 0.297388290245612 3460 19798528 SGTC_11 0438-0307 1.3 µM -0.532411576543369 0.288063464826959 no 2397 0.297220484502498 3427 4011476 SGTC_659 k018-0002 107 µM -0.533517273575138 0.287677297144641 no 2398 0.296837778489557 3432 6797879 YHR007C ERG11 SGTC_1456 k015-0012 13 µM -0.534715641024946 0.28725904053116 no 2399 0.29642325208279 3491 2989616 SGTC_786 4544-0069 423 µM -0.534949781660104 0.287177353915717 no 2400 0.296342291663024 3405 748821 YLR208W SEC13 SGTC_1066 ketoconazole 628 nM -0.539308943579578 0.285658548183408 no 2401 0.294836849357181 3458 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W SGTC_2289 7946404 165.07 µM -0.540203556542345 0.28534732320957 no 2402 0.294528330113589 3363 1246120 YPR165W RHO1 SGTC_2729 fluphenazine 10.66 µM -0.543334598159043 0.284259345564634 no 2403 0.293449723489041 3335 3372 An atypical antipsychotic. SGTC_1463 k081-0032 34.1 µM -0.543924352085622 0.284054639400881 no 2404 0.293246765231548 3358 977755 SGTC_3088 9117578 49.47 µM -0.544513794134642 0.28385011198149 no 2405 0.29304397934696 3471 678341 SGTC_1530 rhein 70.4 µM -0.551270336359008 0.281510744275993 no 2406 0.290724185014364 3450 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death. SGTC_1915 st067105 30.6 µM -0.553021405419949 0.280905979770926 no 2407 0.290124376405574 3462 69751 YOR207C | YOR116C RET1 | RPO31 SGTC_2580 diallyl disulphide 81.36 µM -0.553654726816262 0.280687405106417 no 2408 0.289907582322765 3368 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.  SGTC_2405 ticlatone 3.52 µM -0.553977822620519 0.280575928561468 no 2409 0.289797011735304 3188 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W SGTC_2384 9036245 200 µM -0.554362616058482 0.280443192668291 no 2410 0.289665352660869 3375 6462766 SGTC_546 peri-Naphthalide 147 µM -0.554490536420964 0.280399072808638 no 2411 0.289621590262923 3348 223824 A penicillin ester. SGTC_978 1416-0512 87.4 µM -0.554879894751304 0.280264803420587 no 2412 0.289488407319766 3450 6814003 SGTC_2445 5742597 35.57 µM -0.555346519601997 0.280103929876615 no 2413 0.289328832685153 3327 1774255 SGTC_1314 1222-0010 41.1 µM -0.556599519001695 0.279672167472763 no 2414 0.288900541245206 3408 3526027 SGTC_749 1000-0129 128 µM -0.556601919018474 0.279671340777594 no 2415 0.28889972117472 3503 708470 SGTC_2174 5790901 200 µM -0.556745454418798 0.279621901603883 no 2416 0.288850678032393 3439 786020 SGTC_337 1315-0038 354 µM -0.557012597523039 0.279529898426744 no 2417 0.288759411073533 3400 1626437 SGTC_2320 7373003 200 µM -0.558286244356693 0.279091460985021 no 2418 0.288324468255802 3424 5415828 SGTC_1035 k081-0041 55.2 µM -0.558330087631805 0.279076374425728 no 2419 0.288309501539709 3500 731709 SGTC_2663 amphotericin b 100 µM -0.559147174828497 0.278795285659477 no 2420 0.288030640710952 3440 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_373 0844-0104 25.9 µM -0.55930749947748 0.278740148042213 no 2421 0.287975939017143 3459 5375804 SGTC_3164 9100705 49.47 µM -0.559482990238378 0.278679800698516 no 2422 0.28791606837066 3496 17174235 SGTC_84 0443-0269 128.823 µM -0.559655289855259 0.27862055690726 no 2423 0.287857292137533 3432 6150058 SGTC_1269 0831-0796 3.05 µM -0.560169658122182 0.278443732147081 no 2424 0.287681860409794 3467 927758 SGTC_2550 chrysin dimethyl ether 71.87 µM -0.562497953971536 0.277644016786606 no 2425 0.286888398627758 3374 88881 An O-methylated flavonoid and antioxidant. SGTC_1130 3454-2858 15.9 µM -0.56275009403469 0.277557479932046 no 2426 0.286802533884268 3381 715628 YIL048W NEO1 SGTC_2313 7726885 200 µM -0.563488833689513 0.277304013397789 no 2427 0.286551030800498 3438 726423 SGTC_1750 st081859 2.357 µM -0.566106618908064 0.276406746059663 no 2428 0.285660652045728 3504 5291695 SGTC_700 3453-2283 142 µM -0.567355381935685 0.2759792245074 no 2429 0.285236378597804 3522 565664 SGTC_1583 clindamycin 39.6 µM -0.567790157168244 0.275830452839342 no 2430 0.285088732049866 3392 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis. SGTC_2149 5554786 194.827 µM -0.568317332203878 0.275650116621173 no 2431 0.284909756078286 3419 745063 YPR165W RHO1 SGTC_1771 st048882 4.1505 µM -0.569610639196542 0.275207947406144 no 2432 0.284470905411515 3341 4580403 SGTC_662 k832-1615 104 µM -0.571317544153342 0.274624908109371 no 2433 0.283892205655076 3448 5878478 SGTC_1841 st054148 70 µM -0.571817177317566 0.274454360303888 no 2434 0.283722919417874 3434 675442 SGTC_1091 telmisartan 47.6 µM -0.571920303892094 0.274419164964108 no 2435 0.283687983982619 3510 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension. SGTC_306 1672-3436 11.6 µM -0.572064754433098 0.274369870205551 no 2436 0.283639052993911 3488 6797378 SGTC_2620 irigenin 100 µM -0.572078152111222 0.274365298375601 no 2437 0.283634514886703 3502 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro. SGTC_2335 9018011 154.17 µM -0.572081315505012 0.274364218903112 no 2438 0.28363344337625 3435 6458208 SGTC_3249 9135183 49.47 µM -0.572468733326822 0.274232032789912 no 2439 0.283502231175677 3521 4902779 SGTC_259 usnic acid 108.925 µM -0.57331511633614 0.273943358214999 no 2440 0.283215676071081 3552 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_453 enantio-paf c16 10 µM -0.573966486967275 0.273721298545347 no 2441 0.282995239856593 3487 13871343 A lipid and platelet activating factor SGTC_2776 terbinafine 19.92 µM -0.575000374084128 0.273369017568379 no 2442 0.282645521998812 3475 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_1970 st070122 35.8 µM -0.576665202715421 0.272802225324232 no 2443 0.282082821697185 3555 102928 SGTC_729 4092-0585 94.1 µM -0.57795297629502 0.272364202010979 no 2444 0.281647933653429 3404 2169061 SGTC_2825 7998094 58.44 µM -0.578247372665195 0.272264115114309 no 2445 0.281548559841672 3433 2987815 SGTC_2840 9008771 71.43 µM -0.580080424409863 0.271641337988914 no 2446 0.280930192033048 3410 2992978 SGTC_1074 carmofur 3.8 µM -0.580515980709345 0.271493462612856 no 2447 0.280783356590242 3513 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_602 3130-1533 38.1 µM -0.580719620905047 0.271424338649198 no 2448 0.280714717813038 3517 720941 SGTC_2952 9073731 13.78 µM -0.580899508650912 0.271363284550917 no 2449 0.28065409176642 3426 16457353 SGTC_3262 9137218 49.47 µM -0.581557267878081 0.271140098624218 no 2450 0.280432466673558 3383 17650664 SGTC_1279 0874-0590 65.2 µM -0.581813891888425 0.27105304771911 no 2451 0.280346022879163 3451 3523074 SGTC_2026 5148700 152 µM -0.581983084572294 0.27099566252275 no 2452 0.280289037384982 3435 79838 SGTC_1368 1852-0141 284 µM -0.582663422353307 0.270764973102909 no 2453 0.280059950651676 3467 2838987 SGTC_1939 st074455 53.6 µM -0.582830719650238 0.27070826083795 no 2454 0.280003631376473 3540 1644229 SGTC_3003 9075612 71.4286 µM -0.582923573234538 0.270676786875491 no 2455 0.279972375341621 3482 6501993 SGTC_2863 9028737 58.44 µM -0.582950209844797 0.270667758378016 no 2456 0.279963409335288 3422 6460917 SGTC_3005 9076496 71.4286 µM -0.584108601480328 0.2702752662737 no 2457 0.279573624084999 3497 21368410 SGTC_2444 5485484 36.41 µM -0.584182331877699 0.270250294204065 no 2458 0.279548823588699 3527 6790631 SGTC_46 0329-0187a 2.197 µM -0.585198735955181 0.269906161497448 no 2459 0.279207047370081 3464 46494817 SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM -0.585416720399496 0.269832385198155 no 2460 0.279133774340093 3491 16623 A steroid. SGTC_2277 7947813 106.88 µM -0.585753317782293 0.269718484477102 no 2461 0.279020649265351 3565 1246798 SGTC_682 0kpi-0099 17 µM -0.586058774931615 0.269615142102407 no 2462 0.278918009234452 3506 1714895 YML126C ERG13 SGTC_357 1325-0123 420 µM -0.586951316334969 0.26931329088221 no 2463 0.278618201835907 3490 1098503 SGTC_886 0866-0150 153 µM -0.588928201606259 0.268645326124313 no 2464 0.27795471927501 3561 271463 SGTC_386 1509-0011 3.07 µM -0.589999489647036 0.268283699451284 no 2465 0.277595495830541 3526 3107280 SGTC_801 0866-0028 10.1 µM -0.590751331701672 0.268030052085465 no 2466 0.277343524287461 3519 6849771 SGTC_3206 9114350 49.47 µM -0.590910879447302 0.26797624133232 no 2467 0.277290068014519 3471 17087243 SGTC_3036 9090181 49.47 µM -0.591975761006666 0.267617227535468 no 2468 0.27693340988747 3515 25236586 SGTC_670 4204-0025 119 µM -0.592848613221999 0.267323135366034 no 2469 0.276641235277095 3482 719039 SGTC_1109 tnp00067 928.257 nM -0.593167536514053 0.267215720472111 no 2470 0.276534518030058 3458 676295 SGTC_2184 6075246 200 µM -0.594596511521478 0.266734702453833 no 2471 0.276056606242446 3495 2267320 SGTC_1742 st038235 28.8875 µM -0.595378409990238 0.266471687109561 no 2472 0.275795276939834 3475 564103 YBR002C RER2 SGTC_182 3448-4371 550.524 µM -0.59571473534405 0.266358594206456 no 2473 0.275682906309202 3533 3491403 SGTC_1497 4476-2978 41.3 µM -0.595738192781284 0.266350707305019 no 2474 0.275675069717137 3526 1528379 SGTC_1004 4084-0029 199 µM -0.595955768954339 0.266277559087406 no 2475 0.275602387724236 3529 716894 YLR208W SEC13 SGTC_722 3534-0461 190 µM -0.596328511993838 0.266152268039774 no 2476 0.275477893662566 3484 658262 SGTC_727 3032-0951 202 µM -0.596810356585223 0.265990348660854 no 2477 0.275317001305271 3457 3652836 SGTC_465 cgp-37157 41 µM -0.597373151159944 0.26580128999675 no 2478 0.275129137574736 3427 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange. SGTC_3202 9113761 49.47 µM -0.598178696648749 0.265530802980144 no 2479 0.274860352227445 3504 4798415 SGTC_381 3461-2219 42.7 µM -0.598888596676009 0.265292547711189 no 2480 0.274623588113977 3507 2883159 SGTC_522 1273-0010 11.6 µM -0.599374559878045 0.265129512281115 no 2481 0.27446156888242 3580 5705015 SGTC_166 k072-0058 166.424 µM -0.601677005664268 0.264357758797407 no 2482 0.273694579514077 3540 5846229 SGTC_956 1185-0240 191 µM -0.602157384888885 0.264196885489046 no 2483 0.273534689662752 3498 1416193 SGTC_2759 disulfiram 3.38 µM -0.603258021734035 0.263828483343902 no 2484 0.273168527102592 3470 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_179 1273-0063 6.77 µM -0.603337445354826 0.263801909023543 no 2485 0.27314211365645 3455 3108139 SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM -0.604255350629781 0.263494886503317 no 2486 0.272836943168188 3500 6708739 YPR165W RHO1 SGTC_925 2064-1272 59.6 µM -0.604380592507372 0.263453009530504 no 2487 0.272795317864283 3434 6815817 SGTC_1320 1313-0481 95.3 µM -0.607032545448221 0.262567077572748 no 2488 0.271914656950664 3565 6813365 YLR208W SEC13 SGTC_2859 9028643 45.46 µM -0.607766815591999 0.262322051401804 no 2489 0.271671070656424 3493 17151580 SGTC_2195 6536160 144.242 µM -0.608693604998759 0.262012948774611 no 2490 0.271363773316606 3412 3834386 SGTC_3205 9113483 49.47 µM -0.609578965513708 0.261717837983645 no 2491 0.271070374491048 3530 17018033 SGTC_623 k072-0108 16.9 µM -0.610729308492085 0.261334657419627 no 2492 0.270689399849349 3508 5382803 SGTC_1917 st066507 28.5 µM -0.611076616050877 0.261219025535976 no 2493 0.2705744298783 3455 3156428 SGTC_645 0845-0943 5.41 µM -0.612925263183674 0.260603983352635 no 2494 0.269962878988041 3495 1885106 SGTC_590 k048-0076 22.4 µM -0.614160271336811 0.260193513703108 no 2495 0.269554711779906 3546 6832814 SGTC_1101 ebselen 5.29 µM -0.614268001340579 0.260157724162179 no 2496 0.269519121943755 3593 3194 A potent scavenger of hydrogen peroxide and hydroperoxides. SGTC_2398 5228213 48.84 µM -0.6147826079168 0.259986799070832 no 2497 0.269349148287138 3574 80771 YMR134W ERG29 SGTC_2576 guaiol 23.12 µM -0.614869932112467 0.259957800339404 no 2498 0.269320310592432 3514 227829 SGTC_1551 6-bromo-3'-methylflavone 63.5 µM -0.616348587077568 0.259467020094085 no 2499 0.268832238963272 3611 688751 SGTC_3332 9141069 11.198 µM -0.617497718611054 0.259085942678434 no 2500 0.268453242796018 3518 17332883 SGTC_184 1494-0393 24.714 µM -0.61815904125242 0.25886676474241 no 2501 0.268235253200698 3521 3090647 SGTC_888 0916-0002 6.97 µM -0.620517635092461 0.258085852986469 no 2502 0.267458523646798 3591 2802138 YIL048W NEO1 SGTC_1002 4049-0206 172 µM -0.62120837815725 0.257857384913269 no 2503 0.267231263827418 3559 4662749 SGTC_2995 9067767 71.4286 µM -0.621906684650495 0.257626521908952 no 2504 0.267001614684105 3500 11673567 SGTC_728 3030-5151 22.5 µM -0.621964877876801 0.257607287834443 no 2505 0.266982481420503 3576 3125388 SGTC_2397 5161689 200 µM -0.623057712841509 0.257246221636015 no 2506 0.266623298508213 3613 2259942 SGTC_1612 st002233 45.4 µM -0.623205636741113 0.257197368678312 no 2507 0.266574699026144 3572 1035021 SGTC_923 1900-2434 73.3 µM -0.624003298982251 0.256934018002375 no 2508 0.266312709261814 3542 5910570 SGTC_3229 9132204 49.47 µM -0.624688419889167 0.256707935253942 no 2509 0.26608778743445 3538 17682924 SGTC_1550 gossypolone 36.6 µM -0.626652696551323 0.256060319082434 no 2510 0.265443458804486 3571 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_2330 7979373 200 µM -0.626990679187501 0.255948973207249 no 2511 0.265332672487739 3525 1863007 SGTC_408 cantharidin 100 µM -0.628598541890863 0.255419620917987 no 2512 0.264805957581315 3497 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_1051 3253-3903 78 µM -0.628760608294638 0.255366295991602 no 2513 0.264752896240767 3528 5509239 SGTC_2935 9038016 29.96 µM -0.629190586739335 0.255224847808718 no 2514 0.26461214537898 3567 6463195 SGTC_1731 st035964 63 µM -0.629693453183563 0.255059473955394 no 2515 0.2644475833708 3475 6739575 SGTC_3269 9137823 49.47 µM -0.630353745290441 0.254842413876929 no 2516 0.264231583262013 3494 17682936 SGTC_864 0469-0573 172 µM -0.630480418719746 0.254800783144783 no 2517 0.26419015509676 3496 689425 SGTC_2817 7995342 71.43 µM -0.631840569123583 0.254353999422181 no 2518 0.263745530555044 3482 18879975 SGTC_1521 st012942 49.4 µM -0.631940245439556 0.254321273791344 no 2519 0.263712962014159 3574 24207259 SGTC_1479 0549-0158 134 µM -0.632956661703877 0.253987691044995 no 2520 0.263380972238922 3599 5440202 SGTC_399 oxolinic acid 75 µM -0.634755187495265 0.253397986875133 no 2521 0.262794047074716 3524 4628 A DNA gyrase inhibitor. SGTC_2223 6903751 107.57 µM -0.634761268192195 0.253395994345594 no 2522 0.262792063854731 3540 5598863 SGTC_1202 1988-0068 29.6 µM -0.634955327710071 0.253332409031987 no 2523 0.262728775341837 3485 2850480 SGTC_2684 capsaicin 100 µM -0.636311083460919 0.252888417793582 no 2524 0.262286841159318 3590 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_1651 st011928 86.1 µM -0.636681973547209 0.252767027812911 no 2525 0.262166008899257 3565 720198 SGTC_2108 5365811 200 µM -0.637772964899865 0.252410131173515 no 2526 0.261810740316949 3582 780283 SGTC_1914 st062367 72.6 µM -0.637792225277891 0.252403832901464 no 2527 0.261804470618989 3554 978205 SGTC_2556 citropten 84.59 µM -0.64022419423408 0.251609228853976 no 2528 0.261013427836257 3532 2775 A potential DNA crosslinker. SGTC_1506 4226-2149 212 µM -0.640725167912367 0.251445708612342 no 2529 0.26085062968242 3573 991114 SGTC_2041 5107442 45.335 µM -0.641853564752202 0.251077600222279 no 2530 0.260484133322809 3608 793005 SGTC_2847 9005661 71.43 µM -0.642124589897924 0.250989228214001 no 2531 0.260396145530376 3503 2991449 SGTC_2393 9031399 185.94 µM -0.644768373635314 0.250128045068166 no 2532 0.259538649960594 3630 1526623 YDL150W RPC53 SGTC_2519 cryptotanshinone 88.04 µM -0.64494528915738 0.250070472808764 no 2533 0.259481320557121 3580 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE) SGTC_2312 7706453 155.7 µM -0.645770131212592 0.249802143620344 no 2534 0.259214117179339 3599 976098 SGTC_1133 3473-0247 50 µM -0.645840404480185 0.249779290107631 no 2535 0.259191359088821 3532 711311 SGTC_2452 5863136 48.41 µM -0.64624059674268 0.249649165069321 no 2536 0.259061775987217 3570 2184096 SGTC_3072 9116419 49.47 µM -0.647561344881379 0.2492199711149 no 2537 0.258634352789284 3555 17170162 SGTC_1877 wortmannin 25 µM -0.648436196353392 0.248935893155993 no 2538 0.25835143273314 3603 312145 A covalent inhibitor of PI 3-kinase. SGTC_2960 9079389 5.97 µM -0.648614740065141 0.248877938401236 no 2539 0.258293712817085 3577 16457355 SGTC_565 1418-0001 44.5 µM -0.648636795859253 0.248870779654869 no 2540 0.258286583046112 3628 2862145 SGTC_139 0099-0334 718.624 µM -0.649732650264983 0.248515231415393 no 2541 0.257932464882584 3634 97690 SGTC_1424 4048-1941 275 µM -0.650433586677573 0.248287955699282 no 2542 0.257706094029361 3644 X1424 SGTC_3320 9137005 35.139 µM -0.650631116454642 0.248223927511674 no 2543 0.257642319451897 3557 4908713 SGTC_2999 9069765 71.4286 µM -0.650761809254794 0.248181569001952 no 2544 0.257600128404342 3600 2097066 SGTC_16 erodoxin 22.806 µM -0.650848823225021 0.248153369264125 no 2545 0.257572040013045 3621 3967339 Erodoxin inhibits Ero1. YML130C ERO1 SGTC_945 3381-0768 11.3 µM -0.65120024476003 0.248039496952782 no 2546 0.257458616189972 3622 1126236 YIL048W NEO1 SGTC_219 mitoxanthrone 164.414 µM -0.651800360248062 0.247845103968291 no 2547 0.2572649846155 3568 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA.  YMR168C CEP3 SGTC_2131 toluylene red 5.2905 µM -0.652128204379137 0.247738941104011 no 2548 0.2571592353326 3578 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain. SGTC_604 1000-0114 314 µM -0.652276868787878 0.24769080842701 no 2549 0.257111289644743 3632 1572745 SGTC_2958 9077254 16.72 µM -0.652531660376044 0.247608326853477 no 2550 0.257029127742957 3634 16457351 SGTC_1965 Pectolinarigenin 58.4 µM -0.654166957198877 0.247079295186389 no 2551 0.256502123629908 3594 5320438 An anti-inflammatory. SGTC_542 3381-0244 89.3 µM -0.654314612055581 0.247031557433562 no 2552 0.25645456689273 3614 1112843 SGTC_1475 4092-1048 11.7 µM -0.654519693241669 0.246965261571164 no 2553 0.25638852188193 3603 2881759 SGTC_826 1683-5028 118 µM -0.654756763813055 0.246888636479988 no 2554 0.256312185952317 3611 722377 SGTC_3010 9080089 71.4286 µM -0.654817286137943 0.246869076712489 no 2555 0.256292699864882 3608 17027233 SGTC_690 glyoxal 20.3 µM -0.6548689185875 0.246852390654433 no 2556 0.256276076619092 3527 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins. SGTC_1415 3966-0071 78.1 µM -0.65631915267098 0.246383965233577 no 2557 0.255809398435238 3603 2893185 SGTC_2022 5136654 200 µM -0.657259491751616 0.246080490622531 no 2558 0.255507039187256 3596 1713771 SGTC_3233 9132340 49.47 µM -0.657666371186583 0.245949241039555 no 2559 0.255376267936067 3552 17682950 SGTC_580 1123-0028 41 µM -0.659782435231874 0.245267255446128 no 2560 0.254696728342101 3675 1677248 YPR107C YTH1 SGTC_196 k015-0023 18.111 µM -0.660058184364996 0.245178459279776 no 2561 0.254608245773135 3601 5211998 SGTC_1730 st033808 45.1 µM -0.661226333357417 0.244802486160219 no 2562 0.254233587981044 3604 1045166 SGTC_2200 6600604 21.907 µM -0.662034695025835 0.244542493732523 no 2563 0.253974493302109 3584 2904777 SGTC_2142 5622915 118.518 µM -0.662649068259243 0.244344993104616 no 2564 0.253777668168214 3600 5322196 SGTC_72 0744-0168 198.391 µM -0.663156466711719 0.244181946162169 no 2565 0.253615174665371 3558 677577 SGTC_733 4069-0007 56.1 µM -0.663818505549084 0.243969295459615 no 2566 0.25340324004018 3654 5717425 YNL287W SEC21 SGTC_506 n9-isopropylolomoucine 153 µM -0.665131661177888 0.24354779807122 no 2567 0.252983142780592 3621 6610355 SGTC_1068 loratadine 26.9 µM -0.665238249828138 0.243513602456699 no 2568 0.252949059635283 3610 3957 A H1 histamine antagonist. SGTC_817 1391-0715 46 µM -0.665605173236141 0.243395906460127 no 2569 0.252831749452069 3574 1353946 SGTC_1340 1486-1359 257 µM -0.665790048889683 0.243336616564254 no 2570 0.252772653154983 3586 4309068 SGTC_2705 st078069 42.8 µM -0.665798356520297 0.243333952478074 no 2571 0.252769997755918 3584 1530061 SGTC_1978 st071761 42 µM -0.667554005380415 0.242771305820642 no 2572 0.252209162826503 3572 5147680 SGTC_432 NS 1619 61.3 µM -0.667883295455026 0.242665854105672 no 2573 0.25210404557435 3626 4552 A K+/calcium channel activator. SGTC_1124 fisetin 1.16336 µM -0.667932649112544 0.24265005124837 no 2574 0.252088292700521 3606 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster. SGTC_412 gemfibrozil 100 µM -0.668148120357156 0.242581064685419 no 2575 0.252019523914332 3607 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels. SGTC_1303 1160-0052 261 µM -0.669360885726249 0.242192976667299 no 2576 0.251632648157301 3640 3562476 SGTC_558 k064-0027 21.3 µM -0.669785052581571 0.242057321675823 no 2577 0.251497411753442 3636 5088526 SGTC_1351 1496-0003 46.5 µM -0.670186784623469 0.241928879680135 no 2578 0.251369363624392 3637 3891978 SGTC_3266 9136860 49.47 µM -0.672447430631162 0.241206794552599 no 2579 0.250649448072669 3567 4871271 YPR165W RHO1 SGTC_2011 4012611 177 µM -0.673932150893071 0.240733190112788 no 2580 0.250177225310948 3646 2049887 SGTC_961 1252-1571 372 µM -0.676352879295579 0.239962098940458 no 2581 0.249408313415452 3640 6813498 SGTC_2481 5478948 45.16 µM -0.678108862282034 0.239403597655093 no 2582 0.248851336020013 3642 77792 SGTC_595 3909-8003 73.7 µM -0.678367743915073 0.23932131883382 no 2583 0.248769277815276 3679 699517 SGTC_1501 4491-0275 38.4 µM -0.679309559468006 0.239022117518563 no 2584 0.248470870333474 3630 5104718 SGTC_1032 k061-1018 98.7 µM -0.680212798792708 0.23873536353219 no 2585 0.248184864739672 3722 4005393 SGTC_1482 3346-2049 8.48 µM -0.680491802145938 0.238646825598592 no 2586 0.248096555420744 3634 3826804 SGTC_2167 5876490 200 µM -0.680701485795246 0.238580297162281 no 2587 0.248030198004245 3700 686534 SGTC_2982 9019404 25.97 µM -0.682947919706397 0.237868185848666 no 2588 0.247319876137233 3537 22333232 SGTC_2286 7945697 125 µM -0.683026830504391 0.237843192623104 no 2589 0.247294944348017 3620 1245733 SGTC_3071 9117417 49.47 µM -0.683068458848647 0.237830008358923 no 2590 0.247281792454895 3579 45595590 YGL055W OLE1 SGTC_1700 st030840 7.9285 µM -0.684094095179761 0.237505301969492 no 2591 0.2469578751433 3664 5499307 SGTC_1845 st056753 3.01 µM -0.685515032168171 0.237055849641806 no 2592 0.246509489101913 3604 5375839 SGTC_1930 st074634 34.3 µM -0.686133733483019 0.236860296241978 no 2593 0.246314390214684 3617 684253 YOR116C RPO31 SGTC_105 0111-0055 734.78 µM -0.686304856012555 0.236806225075124 no 2594 0.246260443712629 3617 5179370 SGTC_2360 9040895 200 µM -0.686492615144829 0.236746904897598 no 2595 0.246201259798511 3622 4914414 SGTC_3023 9089636 49.47 µM -0.687727201559756 0.236357056191292 no 2596 0.245812293491123 3731 17249241 SGTC_3009 9080819 71.4286 µM -0.687966211329275 0.236281624281821 no 2597 0.245737029685706 3672 17027216 SGTC_251 melphalan 456.522 µM -0.688099447398387 0.236239580496027 no 2598 0.24569507922606 3707 460612 A DNA alkylator. SGTC_2610 ononetin 44.17 µM -0.689434575831477 0.235818496834699 no 2599 0.245274915608775 3663 259632 SGTC_2000 st075254 36.4 µM -0.689566658357889 0.235776862078433 no 2600 0.245233370373374 3632 17234175 SGTC_1103 duloxetine 36.1 µM -0.689827658296798 0.235694602184835 no 2601 0.245151286583486 3714 60835 A selective serotonin reuptake inhibitor. SGTC_1533 dihydroergotamine mesylate 29.4 µM -0.689916351172784 0.235666652270215 no 2602 0.245123396272684 3711 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release. SGTC_1076 itraconazole 331 nM -0.690640791450382 0.235438426813807 no 2603 0.244895653106906 3682 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1 SGTC_1414 3917-0015 5.4 µM -0.69101818997087 0.235319580673838 no 2604 0.244777055004827 3638 6618702 SGTC_2254 7938975 95.19 µM -0.694059236502777 0.234363137759432 no 2605 0.243822530495324 3707 2969277 SGTC_1578 josamycin 24.2 µM -0.694745194142028 0.23414769420996 no 2606 0.243607499944739 3608 5282165 A P450 substrate. SGTC_1317 1273-0028 910 nM -0.695299909150148 0.233973551188128 no 2607 0.243433685595798 3655 5917803 YLR359W | YHR072W ADE13 | ERG7 SGTC_2315 7733312 200 µM -0.696139970009446 0.233709965508884 no 2608 0.243170588624806 3645 726316 SGTC_1261 0712-0010 12.7 µM -0.696421284000766 0.233621734495871 no 2609 0.243082518835395 3675 2840123 SGTC_2221 6807166 181.081 µM -0.697372221760622 0.233323620195092 no 2610 0.242784940495207 3623 674925 SGTC_190 3970-0790 3.722 µM -0.699139163666598 0.232770253547885 no 2611 0.24223253272456 3636 2832352 SGTC_644 1498-1197 63.3 µM -0.699578284006218 0.232632844117953 no 2612 0.242095354135316 3698 6741615 SGTC_1738 st035555 74 µM -0.699954124191016 0.232515272120164 no 2613 0.24197797735488 3687 5331140 SGTC_884 0851-0618 334 µM -0.7009514094263 0.232203457134005 no 2614 0.241666669836401 3689 9642473 SGTC_3114 9122766 49.47 µM -0.701014882992745 0.232183619127745 no 2615 0.241646863610577 3640 17176985 SGTC_1255 0566-0045 221 µM -0.701079941460307 0.232163286755929 no 2616 0.241626563748412 3710 2788469 SGTC_764 1951-2361 146 µM -0.701617279006085 0.231995393449534 no 2617 0.241458936459234 3653 5438930 SGTC_3024 9090631 49.47 µM -0.702887652516493 0.231598729045461 no 2618 0.241062883313449 3624 25236383 SGTC_655 k060-0012 42 µM -0.705560006727646 0.230765542176663 no 2619 0.240230901313738 3662 5994525 SGTC_287 k060-0039 29.6 µM -0.708042244531011 0.229993131946558 no 2620 0.239459511998085 3716 5861974 SGTC_2369 9071472 200 µM -0.708380842294134 0.229887881066351 no 2621 0.239354393051593 3723 17296037 SGTC_1772 st048439 82.2 µM -0.708501402194571 0.229850412327273 no 2622 0.239316970863871 3673 2927068 YDL195W SEC31 SGTC_1480 1070-0044 41.2 µM -0.708868501510951 0.229736342809109 no 2623 0.239203041719814 3698 3124987 SGTC_971 1315-0384 26.7 µM -0.71199659391168 0.228765631334566 no 2624 0.238233442603867 3708 6769120 SGTC_2666 tannic acid 100 µM -0.712494411338719 0.228611361000019 no 2625 0.238079335470596 3694 16134267 A thiamine antagonist. SGTC_1346 1488-2224 62.4 µM -0.712865726068927 0.228496331069234 no 2626 0.237964424799185 3682 3722427 SGTC_2435 5706476 10.6 µM -0.713392285721229 0.228333263435041 no 2627 0.237801522668298 3697 5725375 SGTC_606 k015-0008 38.6 µM -0.71454084593351 0.227977798569353 no 2628 0.237446404089342 3739 1970475 SGTC_2238 6671620 73.2395 µM -0.717134421944999 0.227176265789448 no 2629 0.236645579068053 3668 729941 SGTC_2628 lathosterol 100 µM -0.719483230858739 0.226451749818951 no 2630 0.235921615403591 3754 6710616 SGTC_2035 5154463 94.595 µM -0.720079431209751 0.226268053101018 no 2631 0.23573804548046 3705 2769623 SGTC_2753 fluvastatin 17.09 µM -0.720627049001679 0.226099399470337 no 2632 0.2355695035357 3726 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5 SGTC_1405 3909-7894 12 µM -0.720628390048262 0.226098986546192 no 2633 0.235569090879446 3707 7104060 SGTC_2420 aureobasidin a 50 nM -0.720912632601364 0.226011474512922 no 2634 0.235481635008504 3747 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1 SGTC_2128 5255449 168.493 µM -0.720943979598522 0.226001824634037 no 2635 0.23547199124793 3721 736008 SGTC_610 4215-0184 155 µM -0.721713961382244 0.225764866106049 no 2636 0.235235178302391 3745 5605015 SGTC_576 1073-0113 22.7 µM -0.7223814369283 0.225559567189147 no 2637 0.235029998275758 3846 5439563 SGTC_2740 felodipine 17.08 µM -0.724055397930169 0.225045163335607 no 2638 0.234515862736444 3635 3333 L-type calcium channel blocker SGTC_1961 st076550 68.7 µM -0.726146512891672 0.224403504062401 no 2639 0.233874478724757 3699 1579337 SGTC_422 cantharidin 155 µM -0.728261414735604 0.223755603251527 no 2640 0.233226788679041 3678 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_115 0527-0192 112.043 µM -0.728600428587392 0.223651845240609 no 2641 0.233123058133569 3766 4233931 SGTC_334 1502-1024 68.5 µM -0.729345531569289 0.223423896442416 no 2642 0.232895163567455 3748 3296216 SGTC_1296 1068-0102 11.9 µM -0.729905935220172 0.223252539702185 no 2643 0.232723842062962 3719 767053 SGTC_1454 4239-0054 42.6 µM -0.730346215279067 0.223117966093648 no 2644 0.232589292794253 3833 1340767 SGTC_979 1426-2828 121 µM -0.732601418792095 0.222429377483843 no 2645 0.231900782759198 3821 747872 SGTC_1404 3909-7820 48.3 µM -0.733079494349814 0.222283560981349 no 2646 0.231754973009815 3688 23741373 SGTC_1183 1254-0324 198 µM -0.734287595276403 0.22191532461366 no 2647 0.231386738279016 3771 5799357 SGTC_2421 5690543 90.72 µM -0.735006955284056 0.221696224968526 no 2648 0.231167629111856 3768 3397993 SGTC_73 0327-0325 16.231 µM -0.735360182105453 0.221588685891034 no 2649 0.23106008249178 3738 53298 SGTC_2627 acetyl isogambogic acid 100 µM -0.735421874964489 0.221569906703459 no 2650 0.231041301793191 3718 6857789 A caspase activator and apoptosis inducer. SGTC_1669 st015249 58.4 µM -0.735576103181947 0.221522963910466 no 2651 0.230994354970838 3799 722793 SGTC_2787 5284540 71.43 µM -0.736674298604106 0.221188868080534 no 2652 0.230660220047191 3771 736958 SGTC_2789 5281112 71.43 µM -0.736746392944123 0.22116694544295 no 2653 0.230638294205232 3758 765948 SGTC_2640 pentamidine 10.38 µM -0.73728535471141 0.221003095911558 no 2654 0.230474418229229 3745 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_1655 st012546 55.1 µM -0.737577068206782 0.220914441205156 no 2655 0.230385747378318 3691 720985 YLR208W SEC13 SGTC_135 0933-0004 26.348 µM -0.738461197655124 0.220645869642465 no 2656 0.230117119030314 3731 21230617 YGL099W LSG1 SGTC_3342 9147791 14.508 µM -0.739256681273468 0.22040438590904 no 2657 0.22987557411434 3687 1838168 SGTC_3026 9090633 49.47 µM -0.740064691928976 0.220159254517858 no 2658 0.229630370796588 3750 25236842 SGTC_687 k029-0044 34.9 µM -0.740211997294572 0.220114582398537 no 2659 0.229585684502667 3751 5829338 SGTC_2345 9052315 157.45 µM -0.741332556574652 0.219774929604071 no 2660 0.229245913164377 3763 6469265 SGTC_1891 st059073 26.2 µM -0.741557041407294 0.219706922184789 no 2661 0.229177879719877 3751 688754 SGTC_2860 9025725 38.96 µM -0.74170652416802 0.219661643258565 no 2662 0.229132583042211 3737 40546248 SGTC_2879 9041815 71.43 µM -0.745999795386038 0.218363483042218 no 2663 0.227833769320462 3705 4942971 SGTC_2327 6189656 200 µM -0.74983246226537 0.217208338748303 no 2664 0.226677807429683 3811 5349088 SGTC_3246 9135460 32.98 µM -0.750079504400212 0.217134002924692 no 2665 0.226603411339757 3682 41446951 SGTC_1272 0839-0021 27 µM -0.75129015565902 0.216769926388066 no 2666 0.226239026228126 3792 5027250 SGTC_1464 k208-0027 110 µM -0.752057773038551 0.216539265454598 no 2667 0.226008158258503 3753 X1464 SGTC_3338 9144300 39.5675 µM -0.752603236936669 0.216375445642978 no 2668 0.225844185962153 3779 4901274 SGTC_2617 dihydrotanshinone i 20.83 µM -0.753760286031809 0.216028185298915 no 2669 0.225496587413108 3779 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12 SGTC_2738 aclarubicin 5.55 µM -0.754202349638379 0.215895595865785 no 2670 0.225363863473712 3696 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31 SGTC_205 1486-1330 71.903 µM -0.754625419863449 0.215768747344492 no 2671 0.225236883486782 3741 4118834 SGTC_2246 7293507 91.5585 µM -0.754631425886425 0.215766946878535 no 2672 0.225235081135224 3812 887656 SGTC_2331 7980721 200 µM -0.755897059094952 0.215387733799873 no 2673 0.224855458673848 3745 2981221 SGTC_3122 9126309 49.47 µM -0.757688368090774 0.214851677518832 no 2674 0.224318782052541 3803 17591206 SGTC_1200 1643-0193 18.4 µM -0.761118437814532 0.21382738130844 no 2675 0.223293164333625 3755 5403974 SGTC_2172 5754775 163.918 µM -0.761797237502824 0.213625013991575 no 2676 0.22309051470639 3744 2263357 SGTC_2069 5228469 200 µM -0.76225646578781 0.21348816975317 no 2677 0.22295347558521 3735 2835210 SGTC_3232 9132874 49.47 µM -0.762314491596228 0.213470882430097 no 2678 0.22293616341429 3761 3784940 SGTC_948 3448-0295 75.3 µM -0.765749041718395 0.212449099165618 no 2679 0.221912820188 3784 678569 SGTC_3192 9110362 49.47 µM -0.765804097696856 0.212432743241301 no 2680 0.221896437829621 3815 16649480 SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM -0.766999957831512 0.212077660985534 no 2681 0.221540770299076 3747 2724278 An inhibitor of dopamine biosynthesis. SGTC_1616 st002734 56.1 µM -0.767239037840372 0.212006713508056 no 2682 0.221469703265617 3763 4026101 SGTC_537 1334-0398 209 µM -0.767504324808823 0.211928005311145 no 2683 0.221390861414862 3750 5846986 SGTC_685 1278-0033 54.9 µM -0.768621214159589 0.211596822060324 no 2684 0.221059104017351 3814 3590572 SGTC_2237 6667747 47.222 µM -0.772895771305348 0.21033211988427 no 2685 0.219792033779592 3761 729940 YDL015C TSC13 SGTC_1397 3532-0190 20.1 µM -0.773103415528985 0.210270797970897 no 2686 0.219730589949092 3707 5322280 SGTC_2614 arthonioic acid 13.39 µM -0.774300380247989 0.209917512669523 no 2687 0.219376589436886 3743 6710684 SGTC_3111 9122088 49.47 µM -0.775374749116604 0.209600708939776 no 2688 0.219059125733757 3687 16876704 SGTC_388 3',4'-dichloroisocoumarin 16.7 µM -0.777961366613856 0.208839136476788 no 2689 0.218295894506388 3851 1609 A potent and irreversible inhibitor of serine proteases. SGTC_1522 st012842 45.6 µM -0.780017335920876 0.208234966301905 no 2690 0.217690335571518 3705 3491067 YOR116C RPO31 SGTC_2970 9090938 41.86 µM -0.780156713243247 0.2081940460363 no 2691 0.217649318908946 3805 17217104 SGTC_478 N-arachidonylglycine 10 µM -0.78093214206831 0.20796647188061 no 2692 0.21742120323225 3742 5283389 SGTC_731 3966-0296 387 µM -0.780953290795136 0.207960267174795 no 2693 0.217414983633408 3818 660956 SGTC_552 k242-0005 476 µM -0.781042119753281 0.207934207340836 no 2694 0.217388861173924 3859 4088318 SGTC_1717 st033143 58.0435 µM -0.782859260113299 0.207401534469529 no 2695 0.216854881760686 3789 674616 SGTC_1246 0422-0085 105 µM -0.783004038395039 0.207359129179746 no 2696 0.216812370288918 3814 264295 SGTC_2573 2',4'-dihydroxychalcone 15.04 µM -0.784155546621317 0.20702203712143 no 2697 0.216474422753405 3821 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_1832 st054113 55 µM -0.786437290186998 0.206355039007763 no 2698 0.215805672081618 3760 1251267 SGTC_2443 5493264 126.67 µM -0.787506433089762 0.206042946356781 no 2699 0.215492732020502 3843 5340055 SGTC_2117 5521686 200 µM -0.787978069850309 0.2059053602701 no 2700 0.215354766796957 3786 803312 SGTC_1584 6-fluoro-dl-tryptophan 90 µM -0.789419860030698 0.205485098694808 no 2701 0.214933326043363 3851 94937 An inhibitor of serotonin biosynthesis. SGTC_1273 0849-0096 14.1 µM -0.790094047046511 0.205288757548649 no 2702 0.214736423090795 3834 5286025 SGTC_1995 st072814 61.1 µM -0.791010119871389 0.205022151510358 no 2703 0.214469043050033 3790 5769371 SGTC_2648 atorvastatin 78.68 µM -0.791540228306756 0.204867967315785 no 2704 0.214314405368439 3809 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11 SGTC_836 0330-0104 1.35 µM -0.792234718082771 0.204666076507595 no 2705 0.214111914252248 3819 46494820 SGTC_788 1182-0090 188 µM -0.793417157549633 0.204322609317275 no 2706 0.213767408809412 3929 5715185 SGTC_268 camptothecin 39.6153 µM -0.793542415960213 0.204286245196089 no 2707 0.213730933511257 3816 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_1364 1653-0028 37.6 µM -0.794093106934145 0.204126418269957 no 2708 0.213570615093449 3826 5718652 SGTC_2278 7948257 134.34 µM -0.794650539744912 0.203964710540094 no 2709 0.213408405361036 3805 1247028 SGTC_2744 captopril 92.04 µM -0.794690948631069 0.203952991146008 no 2710 0.213396649400564 3768 44093 angiotensin-converting enzyme (ACE) inhibitor  SGTC_974 1326-0144 138 µM -0.796260442994879 0.20349811655915 no 2711 0.212940336197306 3876 5411856 SGTC_1528 arabinosylhypoxanthine 74.6 µM -0.797118548890187 0.203249674351351 no 2712 0.212691092308031 3874 804 An inhibitor of viral and cellular DNA polymerases. SGTC_2562 3',7'-dimethoxyflavone 64.92 µM -0.797829457467338 0.203043986468161 no 2713 0.212484732166067 3879 688664 SGTC_1048 3161-0300 24.5 µM -0.798013239226408 0.202990832935617 no 2714 0.212431403650528 3834 2165101 SGTC_2198 6589944 200 µM -0.799783573350142 0.202479240924641 no 2715 0.211918100983195 3831 5290268 SGTC_396 dithiazanine 1.25 µM -0.800204561812604 0.202357697025307 no 2716 0.211796143603336 3821 10578 An antihelmenthic. SGTC_926 2268-1401 59.4 µM -0.802318585344686 0.201748015669371 no 2717 0.211184347144618 3809 2931578 SGTC_1831 st055328 12 µM -0.802540315922975 0.201684132692322 no 2718 0.211120238578744 3804 1103068 SGTC_738 1315-0003 72.4 µM -0.803389766019289 0.201439509076304 no 2719 0.210874744157672 3846 6251474 SGTC_3238 9133470 49.47 µM -0.80481083775668 0.201030668325208 no 2720 0.21046442331373 3819 3534688 SGTC_141 0443-0274 32.331 µM -0.805418651839239 0.200855952975069 no 2721 0.210289066008745 3886 1627241 SGTC_577 r071-0003 38.6 µM -0.806205263868568 0.200629977710482 no 2722 0.210062252041316 3869 4568517 YMR134W ERG29 SGTC_459 nigericin 15.3 µM -0.80630448695154 0.200601484081432 no 2723 0.21003365198511 3867 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification. SGTC_2902 5787006 60.46 µM -0.806470306217654 0.200553871626979 no 2724 0.20998586135552 3801 591003 SGTC_763 3453-1109 128 µM -0.807708637788353 0.20019851835862 no 2725 0.209629164961975 3835 1560353 SGTC_2261 9010538 184.68 µM -0.810782777663943 0.199317996264859 no 2726 0.208745213239095 3836 6457250 SGTC_730 1436-0052 41.2 µM -0.813094323243991 0.198657441700969 no 2727 0.20808199046156 3870 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2 SGTC_1619 st003326 88.7 µM -0.814114253764147 0.198366403384887 no 2728 0.207789750494588 3803 2849032 SGTC_1148 3909-7663 27.7 µM -0.81542730248913 0.197992102533253 no 2729 0.207413880728924 3913 4084526 SGTC_487 nimodipine 119 µM -0.815652879537417 0.197927841955156 no 2730 0.207349348135266 3731 4497 L-type voltage-gated calcium channels inhibitor SGTC_2012 4023501 200 µM -0.818989633672027 0.196978766380152 no 2731 0.206396164008988 3884 3477460 SGTC_349 k015-0014 24 µM -0.823776625338886 0.195622019319003 no 2732 0.205033245717899 3859 2196908 SGTC_2183 6420625 130.508 µM -0.82446059584722 0.195428630149743 no 2733 0.204838948212264 3852 2897619 SGTC_3318 9139014 38.6185 µM -0.82666963277904 0.194804829849781 no 2734 0.204212168937278 3853 16643984 SGTC_440 fluspirilene 35.1 µM -0.830712973011655 0.193666190264809 no 2735 0.203067897933552 4001 3396 An atypical antipsychotic. SGTC_513 4245-1575 41.7 µM -0.8310916299741 0.193559765410331 no 2736 0.202960933879929 3811 719745 SGTC_2555 cholic acid 100 µM -0.831774371196295 0.193367965173239 no 2737 0.202768156327267 3895 6708657 Influences liver metabolism. SGTC_102 gallobenzophenone 83.616 µM -0.831886606308868 0.193336446436081 no 2738 0.202736476301635 3878 70837 SGTC_2932 9016711 44.54 µM -0.832802681088592 0.193079304428614 no 2739 0.202478011207699 3893 7117328 SGTC_3295 9122362 53.5725 µM -0.834702953286659 0.192546564648276 no 2740 0.201942489215339 3936 4730473 SGTC_2536 dehydroabietamide 32.04 µM -0.835022557267686 0.192457052279474 no 2741 0.20185250392417 3938 3983547 SGTC_911 3456-4043 236 µM -0.836715489697043 0.191983332458999 no 2742 0.201376255133025 3949 914281 SGTC_477 mead ethanolamide 10 µM -0.836809776454219 0.191956969941856 no 2743 0.201349750584479 3743 16061185 SGTC_424 splitomicin 100 mM -0.837201951093955 0.191847341938584 no 2744 0.201239530481033 3988 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_697 0508-1955 564 µM -0.837702248087886 0.191707545199558 no 2745 0.20109897527121 3855 6243113 SGTC_3219 9131112 49.47 µM -0.840500914152212 0.190926672067522 no 2746 0.200313794623677 3842 17612988 YMR079W SEC14 SGTC_2864 9034755 47.6 µM -0.841865277623983 0.190546701050274 no 2747 0.199931683975522 3854 4930451 SGTC_3186 9110464 49.47 µM -0.842053104798022 0.190494428141783 no 2748 0.19987911447679 3887 17018021 SGTC_3086 9117350 49.47 µM -0.842061321144992 0.190492141706939 no 2749 0.199876815056612 3805 2679265 SGTC_1147 3809-1045 12.3 µM -0.843913763445358 0.189977076602511 no 2750 0.199358798275879 3867 325925 SGTC_2085 5307070 144.047 µM -0.84452003938874 0.189808689808915 no 2751 0.199189435061092 3851 2840351 SGTC_1310 1188-0297 994 nM -0.845730679236315 0.189472721989236 no 2752 0.198851502175868 3806 1588352 SGTC_650 1328-0195 38 µM -0.847132156341835 0.189084251765465 no 2753 0.198460731685748 3826 2780821 SGTC_3213 9129884 49.47 µM -0.847556888018846 0.188966618898654 no 2754 0.198342396315222 3907 17190742 SGTC_2358 9037157 4 µM -0.848599619126092 0.188678017360196 no 2755 0.198052059492493 3902 2388925 SGTC_3078 9116413 49.47 µM -0.849133057827832 0.18853048016008 no 2756 0.197903628730696 3821 17177322 SGTC_1275 0867-0008 21.1 µM -0.849592194127186 0.188403550322822 no 2757 0.197775926638879 3866 3422836 SGTC_42 0133-0086 60.653 µM -0.851535953678955 0.187866775332913 no 2758 0.197235849979464 3805 162923 Model of phenazepam hydroxylation. SGTC_1309 pyrazolanthrone 13.4 µM -0.856784661522308 0.186422053431543 no 2759 0.195781952071425 3909 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14 SGTC_2473 5854593 8.94 µM -0.857678278989336 0.186176770021149 no 2760 0.195535068623245 3816 2872951 SGTC_1033 k072-0102 21.3 µM -0.857770836162358 0.186151376023907 no 2761 0.195509508273859 3884 5965931 SGTC_2543 pimpinellin 60.67 µM -0.857927534387613 0.18610838917378 no 2762 0.195466239523327 3768 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo. SGTC_2475 5812728 15.03 µM -0.858493988605321 0.18595304574804 no 2763 0.195309874233903 3891 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2 SGTC_1665 st014639 11.4 µM -0.85937845450401 0.185710652176573 no 2764 0.195065876313964 3958 981133 YIL048W NEO1 SGTC_1950 st077106 7.18 µM -0.860013324733133 0.185536782810094 no 2765 0.194890848733261 3923 13831864 SGTC_807 1315-0151 48 µM -0.861445936145185 0.185144810604428 no 2766 0.194496242686834 3894 4011080 SGTC_2654 protoveratrine a 100 µM -0.863356678250093 0.184622819757284 no 2767 0.193970695278107 3912 5702278 A heart drug and vasodilator. SGTC_403 arphamenine a 50 µM -0.863397266424602 0.184611741510785 no 2768 0.193959540941847 3895 5487158 An arginine aminopeptidase inhibitor. SGTC_1862 st057513 3.81 µM -0.8644548962753 0.184323214884171 no 2769 0.193669023675378 3889 5393163 SGTC_164 4100-3994 89.624 µM -0.865149193265765 0.184133959886389 no 2770 0.193478453598885 3875 4615967 SGTC_976 1348-1067 47.6 µM -0.865446609727696 0.184052925615701 no 2771 0.193396853977504 3961 5310671 YGL099W LSG1 SGTC_2747 doxorubicin 7.63 µM -0.865523907382237 0.184031868685074 no 2772 0.193375649916647 3821 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_862 0452-0056 10.2 µM -0.865735401973688 0.183974262353288 no 2773 0.193317640605039 3894 1575396 YLR359W | YHR072W ADE13 | ERG7 SGTC_352 k048-0007 5.11 µM -0.866402360513641 0.183792671514609 no 2774 0.19313477496173 3934 6811911 SGTC_2144 5628481 200 µM -0.867920173704149 0.183379837320105 no 2775 0.192719017111962 3913 2818399 SGTC_1382 3002-2117 298 µM -0.868443395560342 0.183237658867912 no 2776 0.192575823559079 3985 1497314 SGTC_2696 st077691 74.316 µM -0.869939377515435 0.182831525451769 no 2777 0.192166767296812 3971 757133 SGTC_1102 cgs 12066b 26.1 µM -0.872093715598446 0.182247647701009 no 2778 0.191578627123638 3942 6438352 A 5-HT1B full agonist. SGTC_692 k241-0027 77.8 µM -0.872616433720079 0.182106154307667 no 2779 0.191436090050203 3982 3600480 SGTC_468 gf-109203x 121 µM -0.872819263557984 0.182051269253397 no 2780 0.191380799023183 3896 2396 A protein kinase C inhibitor. SGTC_1086 cerivastatin 2.18 µM -0.874950973110283 0.181475061684403 no 2781 0.190800291149002 3887 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7 SGTC_492 tmb-8 126 µM -0.875407914612199 0.181351697751122 no 2782 0.190675997449 3871 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1 SGTC_1332 1480-0653 17.5 µM -0.876747117534754 0.180990445620198 no 2783 0.190312004162282 3927 5749438 SGTC_1778 st046819 58.9 µM -0.879116281525625 0.180352465207457 no 2784 0.189669115340321 3996 671715 SGTC_23 0213-0011 39.996 µM -0.880638914610691 0.179943188687567 no 2785 0.189256644481025 3943 627608 SGTC_2743 auranofin 4.32 µM -0.88180443952187 0.179630295582499 no 2786 0.188941285231348 3884 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold. SGTC_3271 9137798 49.47 µM -0.881892928457939 0.179606554096863 no 2787 0.18891735576876 3868 6498326 SGTC_1993 st073995 70.8 µM -0.883511530846603 0.179172632804256 no 2788 0.188479977614529 3930 3098394 SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM -0.883730768250069 0.179113909527361 no 2789 0.188420783419795 4007 5393153 SGTC_2707 st078556 66.6 µM -0.88533665901454 0.178684136970811 no 2790 0.187987541892092 3916 17250899 SGTC_86 0417-1630 471.922 µM -0.887101733322174 0.17821251301821 no 2791 0.187512065479043 3966 3634867 SGTC_3236 9132701 49.47 µM -0.887474461505227 0.178113021293034 no 2792 0.187411754936065 3954 24282524 SGTC_622 1348-1566 26.3 µM -0.887486301073739 0.178109861550234 no 2793 0.187408569153574 3998 7340407 SGTC_1041 0206-0046 107 µM -0.888010725720931 0.17796993860431 no 2794 0.187267490931311 3973 50494 SGTC_2229 7354935 190 µM -0.888755472036951 0.177771350278537 no 2795 0.187067255698048 3878 318112 SGTC_234 nsc-17383 10.7 µM -0.889040453890574 0.177695396204158 no 2796 0.18699066947701 3948 408974 SGTC_1848 st056003 16.4 µM -0.89043899935561 0.177322949244633 no 2797 0.186615104656355 3981 146492 SGTC_1822 st052468 42 µM -0.890810572168694 0.177224078543335 no 2798 0.186515401228948 3960 2873678 SGTC_22 0964-0034 14.468 µM -0.890964561380558 0.177183114219683 no 2799 0.186474091266788 4002 138402 SGTC_2861 9024595 19.48 µM -0.891028211790083 0.177166183637882 no 2800 0.186457017725958 3848 16482810 SGTC_2325 6158266 200 µM -0.891070691902168 0.177154884781726 no 2801 0.1864456234295 3993 3623240 SGTC_2814 7977482 42.97 µM -0.89229549215887 0.176829308294867 no 2802 0.186117284912693 4033 6456762 SGTC_1218 1348-1416 30.7 µM -0.894073170672424 0.176357438968531 no 2803 0.185641371514349 3904 6787668 SGTC_1334 1486-0610 236 µM -0.894945689740104 0.176126128108335 no 2804 0.185408060495568 4041 3742339 SGTC_2588 indole-3-carbinol 100 µM -0.895840545202491 0.175889095294745 no 2805 0.185168965904188 4026 3712 Induces cell cycle arrest. SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM -0.896574748355757 0.175694767645837 no 2806 0.1849729387571 3906 279621 SGTC_2737 bleomycin 30.5 nM -0.897211842457414 0.175526252930063 no 2807 0.184802943584057 3992 16211318 Bleomycin acts by induction of DNA strand breaks. SGTC_2402 5553605 200 µM -0.897595124016987 0.175424922325285 no 2808 0.184700719754008 4049 6758546 SGTC_2196 6573537 42.6665 µM -0.89780695410412 0.175368935360379 no 2809 0.18464423829833 3987 2903087 SGTC_1115 galangin 695.678 nM -0.898970838230073 0.175061521435968 no 2810 0.184334096928042 3986 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_1671 st016596 74.5 µM -0.900897154177365 0.174553479871368 no 2811 0.183821502235034 4016 2829167 SGTC_25 0118-0223 35.662 µM -0.901882939012353 0.174293854091626 no 2812 0.183559527632584 3966 5333628 SGTC_299 1273-0059 1.44 µM -0.902332275002084 0.174175594094701 no 2813 0.18344019279387 3859 2848077 SGTC_2642 cholecalciferol 100 µM -0.904055904921068 0.173722427939725 no 2814 0.18298287916829 3969 9821465 A vitamin D precursor, similar to steriods. SGTC_1592 4',5'-dihydroxyflavone 8.85 µM -0.905013439072546 0.173471003334715 no 2815 0.182729133778675 3978 688669 SGTC_2561 acetosyringone 100 µM -0.905484153638415 0.173347490375035 no 2816 0.182604475569384 3976 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent. SGTC_1897 st060201 15 µM -0.906989176145243 0.172952956391893 no 2817 0.18220626053957 4019 611878 SGTC_3283 9109332 35.8195 µM -0.907912787653237 0.172711119858018 no 2818 0.181962150438947 3818 17027281 SGTC_154 3389-1638 511.116 µM -0.908352366814133 0.172596097104691 no 2819 0.181846041730601 3995 5238686 SGTC_1402 3909-7673 35.9 µM -0.910105634658746 0.172137813247493 no 2820 0.181383401634259 3980 5328014 SGTC_1291 0993-0025 5.79 µM -0.910206315145111 0.172111520137476 no 2821 0.18135685716217 3976 4353356 SGTC_1510 1123-0200 71.5 µM -0.91292386398789 0.171402789934065 no 2822 0.180641292798776 4048 5378812 YNL149C | YNL150W PGA2 | YNL150W SGTC_39 0986-0283 58.349 µM -0.913495995923736 0.171253817341314 no 2823 0.180490869261322 4087 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2 SGTC_2773 thioridazine 9.09 µM -0.914168790421936 0.171078740022947 no 2824 0.180314080324548 4015 5452 An antipsychotic. SGTC_2922 7999257 32.47 µM -0.916818521954054 0.17039032987752 no 2825 0.179618872584536 3948 2988377 SGTC_18 0111-0177 500 nM -0.917286902296348 0.170268827701572 no 2826 0.179496159462507 4033 721752 SGTC_878 0828-0289 13.7 µM -0.917326106856576 0.170258660195538 no 2827 0.179485890469908 3945 745350 YLR208W SEC13 SGTC_1666 st014829 29 µM -0.918919170691897 0.169845836143754 no 2828 0.179068925905073 3981 3858230 SGTC_148 3253-0744 288.01 µM -0.919534003042297 0.169686681256314 no 2829 0.178908164335173 3904 6893655 SGTC_286 k060-0067 22.9 µM -0.920960348084392 0.169317827507089 no 2830 0.178535564670406 3993 5985051 SGTC_38 0929-0051 58.268 µM -0.92129183665675 0.169232178106745 no 2831 0.17844904098782 4009 1379719 SGTC_3013 9080133 71.4286 µM -0.922729456857828 0.168861050438417 no 2832 0.178074105482698 4096 17050193 SGTC_865 0488-0499 301 µM -0.923736499093756 0.168601389953406 no 2833 0.177811761978723 4004 9634651 SGTC_2391 6285546 200 µM -0.924009306105711 0.168531092323205 no 2834 0.177740735302668 3980 846083 SGTC_3270 9137563 49.47 µM -0.925155627379588 0.168235911219071 no 2835 0.177442480461838 3988 17015724 SGTC_2418 pentamidine 31.67 µM -0.925238837527767 0.168214497315931 no 2836 0.177420842790891 3975 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_694 1315-0438 43.2 µM -0.926091470583744 0.167995175585125 no 2837 0.177199223113435 3982 6793154 SGTC_2828 7998861 71.43 µM -0.926782890462974 0.167817457715852 no 2838 0.177019635027239 3953 2988188 SGTC_794 k038-0031 316 µM -0.93070502126513 0.166811631702665 no 2839 0.176003085791929 4002 6624242 SGTC_1861 st057647 17.4 µM -0.931556961696463 0.166593667751584 no 2840 0.175782766987326 4098 688668 SGTC_338 4055-0136 114 µM -0.932757593184933 0.166286805458924 no 2841 0.175472570538789 3949 2900563 SGTC_269 exalamide 29 µM -0.933500562421185 0.166097097309114 no 2842 0.175280790100905 3926 3316 A derivative of salicylamide. SGTC_1974 st069448 26.9 µM -0.933699644029128 0.166046288006933 no 2843 0.175229424345096 3988 6323587 YNR016C ACC1 SGTC_1786 berberine 21.6 µM -0.93450989487004 0.165839600656461 no 2844 0.175020467137424 3926 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_2803 7707263 71.43 µM -0.935040011257762 0.16570446300021 no 2845 0.174883839952186 3985 2199229 SGTC_1885 st057546 99.9 µM -0.936337039904519 0.165374123820363 no 2846 0.174549841546147 4058 702008 SGTC_371 0195-0006 7.36 µM -0.939661093442694 0.164529470008726 no 2847 0.173695713986987 3866 3928593 SGTC_1567 st069303 68.4 µM -0.942610263123713 0.163782420479277 no 2848 0.17294014417038 4093 5581319 SGTC_1403 3909-7815 62.9 µM -0.942620658265561 0.163779791202107 no 2849 0.172937484670525 3972 6615483 SGTC_1770 st043884 66.3 µM -0.942713173221272 0.163756392299196 no 2850 0.172913816732069 4024 670149 SGTC_49 0717-0965 32.132 µM -0.942789972503805 0.16373696985619 no 2851 0.172894170874589 4096 5889349 YGL099W LSG1 SGTC_1866 st057638 64 µM -0.942841491711632 0.163723941550676 no 2852 0.172880992655205 3995 688802 SGTC_2532 xanthone 78.9 µM -0.943202039176433 0.163632784244416 no 2853 0.172788785286062 4040 7020 An insecticide. SGTC_2819 7996655 46.38 µM -0.943732638544978 0.163498692615265 no 2854 0.172653145409477 3982 6456960 SGTC_2130 NSC 7 2.4545 µM -0.943899131287112 0.163456631735722 no 2855 0.172610597999969 4086 21448 SGTC_1948 st076329 66.6 µM -0.945047993250863 0.163166587572249 no 2856 0.172317187268702 3888 24208413 SGTC_1339 1486-1321 22.7 µM -0.945547005612155 0.163040710089511 no 2857 0.172189842432561 4034 3469382 SGTC_1336 1486-0901 104 µM -0.945616779318916 0.16302311447773 no 2858 0.172172041405531 4041 5006114 SGTC_806 3966-4455 5.86 µM -0.949822994931176 0.161964666691833 no 2859 0.171101099830174 4013 714982 SGTC_1063 disulfiram 1.84 µM -0.950720501590095 0.161739399841161 no 2860 0.170873139002553 4025 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_3118 9124250 49.47 µM -0.951749774903179 0.161481312109668 no 2861 0.170611949650931 3975 1504786 SGTC_1001 4048-4355 44.4 µM -0.953215370984367 0.161114281192087 no 2862 0.170240479968364 4014 21824233 SGTC_236 1509-0011 5.31 µM -0.95383845057702 0.160958407682795 no 2863 0.170082711440041 4090 3107280 SGTC_59 0330-0160 1.33 µM -0.954820287463432 0.160712985019889 no 2864 0.169834293049819 3992 4293482 SGTC_973 1325-0077 65.9 µM -0.955221403710024 0.160612791240837 no 2865 0.169732872033065 4050 2835149 SGTC_2525 harmine 47.85 µM -0.956356040135169 0.160329594352819 no 2866 0.169446193076898 4026 5280953 A monoamine oxidase inhibitor SGTC_1524 corynanthine 62.1 µM -0.956795766005931 0.160219929810906 no 2867 0.169335174866144 4171 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist. SGTC_2760 etidronate 98.04 µM -0.957431353555149 0.160061505417777 no 2868 0.169174789713326 4001 3305 A chelator and antioxidant. SGTC_142 0335-0849 62.6745 µM -0.959596692311442 0.159522549594985 no 2869 0.168629117211402 4039 3889043 YPR107C YTH1 SGTC_919 tnp00227 403.569 nM -0.959879078551801 0.159452350927216 no 2870 0.168558038431169 4016 1269246 A methoxyflavone. YNL221C POP1 SGTC_2324 6149169 200 µM -0.960078335625074 0.159402829590499 no 2871 0.168507895491303 3945 2888231 SGTC_2215 7188065 200 µM -0.960175287895109 0.159378737696473 no 2872 0.168483500971341 4053 940217 SGTC_1733 st037357 54.9 µM -0.963118460593889 0.15864851666429 no 2873 0.167744039254389 3958 1272339 YGL099W LSG1 SGTC_1370 2001-0092 44.6 µM -0.964129196382457 0.15839825311873 no 2874 0.167490578278357 4119 790957 SGTC_2023 5144124 124 µM -0.96433713484592 0.158346798589884 no 2875 0.167438464422799 4030 2830192 SGTC_3171 9103192 49.47 µM -0.965161997581343 0.158142793730329 no 2876 0.167231839001878 4077 13018434 SGTC_3097 9117246 49.47 µM -0.965423271043274 0.158078211628339 no 2877 0.16716642514353 4063 16423892 SGTC_584 0986-0246 15.4 µM -0.967223561269942 0.157633682945687 no 2878 0.166716143098361 4143 53315 YDR232W HEM1 SGTC_858 0438-0351 2.77 µM -0.968180766942341 0.157397663923764 no 2879 0.166477049283141 4018 2799119 SGTC_372 0155-0182 15.9 µM -0.968680558142864 0.157274522329681 no 2880 0.166352297889715 3962 771486 SGTC_1126 isoteolin 1.0172 µM -0.969501996151542 0.157072269078002 no 2881 0.166147392371353 3993 133323 SGTC_2439 5492030 7.2 µM -0.97047009203081 0.156834125647399 no 2882 0.16590611284233 4040 5722370 SGTC_454 lyso-paf C-16 6.67 µM -0.97144293502128 0.156595053926132 no 2883 0.165663878432813 4047 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_822 1487-0950 154 µM -0.973660166597308 0.156051076363328 no 2884 0.165112650797512 4076 1958375 SGTC_1050 3232-1156 69.3 µM -0.973898259146238 0.155992736658911 no 2885 0.165053529102431 4035 700529 SGTC_634 1611-4317 11.2 µM -0.975815698049793 0.155523431617828 no 2886 0.164577902039929 4061 2843522 SGTC_673 1082-0474 110 µM -0.976139245167178 0.155444333399169 no 2887 0.164497732775396 4070 3098046 SGTC_2748 diazoxide 86.69 µM -0.976529735334171 0.155348904832965 no 2888 0.164401009919196 4089 3019 A potassium channel activatior. SGTC_2647 atorvastatin 60.16 µM -0.976664053863607 0.155316088809855 no 2889 0.164367748279097 4027 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7 SGTC_3125 9127534 49.47 µM -0.978367862456331 0.154900220026752 no 2890 0.163946208516025 3948 1639235 SGTC_3327 9140648 26.9345 µM -0.979238751676425 0.154687936066834 no 2891 0.163731012720573 4098 8029710 SGTC_2241 6772625 37.8075 µM -0.979792926641598 0.15455295305066 no 2892 0.163594172183463 3927 2285411 SGTC_136 0097-0015 404.482 µM -0.980524432498687 0.154374895951515 no 2893 0.163413657671228 4059 4861337 SGTC_3142 9086498 49.47 µM -0.981503006159113 0.154136911817332 no 2894 0.163172376347889 3994 25236367 SGTC_2466 5983409 37.09 µM -0.981614572030655 0.154109794984474 no 2895 0.163144882896881 4090 2879657 SGTC_2507 purpurin 79.67 µM -0.982184187914782 0.153971395217219 no 2896 0.163004557987326 4079 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1 SGTC_2827 7993847 71.43 µM -0.982343664101583 0.153932661973914 no 2897 0.162965285081238 4148 2985692 SGTC_1681 tripelennamine 100 µM -0.982816517657443 0.153817854194907 no 2898 0.162848875437427 4027 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist. SGTC_233 rapamycin 362 pM -0.986327152083508 0.15296725283972 no 2899 0.161986299964125 4060 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C SGTC_2611 pyromycin 23.93 µM -0.986381048375773 0.152954218509912 no 2900 0.161973080689708 4056 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release. SGTC_725 1497-0963 19 µM -0.987719073170551 0.152630865401857 no 2901 0.161645125387487 4170 3549977 SGTC_121 0557-0495 61.343 µM -0.990014887086582 0.152077106011652 no 2902 0.161083421277328 4188 3104427 SGTC_2797 7859098 81.82 µM -0.990563936104545 0.151944871170587 no 2903 0.160949277440875 4067 972681 SGTC_1088 bifonazole 369 nM -0.99067037649775 0.151919244544389 no 2904 0.160923280329475 4026 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase. SGTC_1954 st077032 68.9 µM -0.992506276408771 0.151477684515599 no 2905 0.16047530963558 4062 698907 SGTC_2700 st077718 96.8 µM -0.996993570441616 0.150402021576889 no 2906 0.159383815408823 4073 904970 SGTC_2649 anisomycin 9.56 µM -1.0031253983054 0.148940390313809 no 2907 0.157900180836044 4098 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_2698 st077697 67.5 µM -1.00446643029298 0.148622000262436 no 2908 0.157576922086371 4066 3154499 SGTC_332 4112-0506 40.9 µM -1.00457050483168 0.148597309752938 no 2909 0.157551852882594 4044 2790355 SGTC_2986 9022445 71.43 µM -1.00801051411205 0.14778274968094 no 2910 0.156724707374516 4120 6459286 SGTC_3223 9129970 49.47 µM -1.0086528885188 0.147630973714709 no 2911 0.156570566588619 4124 17248386 SGTC_2233 sulbentine 40.3845 µM -1.00865890683796 0.147629552240004 no 2912 0.156569122936471 4087 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58 SGTC_2523 spermine 47.74 µM -1.00952472284946 0.147425149544263 no 2913 0.156361525510939 4112 1103 A DNA binding polyamine. SGTC_1958 st076513 41.9 µM -1.01110478140766 0.147052616791154 no 2914 0.155983141074183 4059 732122 YGL099W LSG1 SGTC_1489 4065-0444 182 µM -1.01218168744344 0.146799075080534 no 2915 0.1557255951944 4083 2877968 SGTC_24 0417-1663 219 µM -1.01222564192386 0.146788732876551 no 2916 0.15571508928499 4122 4329390 SGTC_1117 retinoic acid 1.10837 µM -1.01414982964228 0.146336463060653 no 2917 0.155255632003483 4152 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR). SGTC_1780 st038448 24.544 µM -1.01463125163374 0.146223453939962 no 2918 0.155140818214564 4158 728868 YDL195W SEC31 SGTC_1252 0493-0875 34.8 µM -1.01566131672451 0.145981853110837 no 2919 0.154895347474968 4099 3960963 SGTC_2812 7970281 58.44 µM -1.01643238939407 0.145801174353087 no 2920 0.15471176418027 4156 2233435 SGTC_41 0478-0632 82.643 µM -1.01715305118934 0.145632443878879 no 2921 0.154540313148044 4031 3750424 SGTC_2955 9076254 12.21 µM -1.01845381770416 0.145328224396773 no 2922 0.154231168726851 4036 16459619 SGTC_2570 licareol 100 µM -1.01958656266721 0.145063649802496 no 2923 0.153962290246473 4110 443158 SGTC_1534 6-azauridine 81.6 µM -1.02010432634071 0.144942824064363 no 2924 0.153839492580192 4132 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1 SGTC_514 4466-0038 2.65 nM -1.02526179893284 0.143742971248883 no 2925 0.15261983780675 3949 5722064 SGTC_2307 7538926 6.34 µM -1.0268524013182 0.143374283907969 no 2926 0.152244985174454 4100 96582 SGTC_3094 9117742 49.47 µM -1.02732912801727 0.1432639074194 no 2927 0.152132755535878 4044 17149698 SGTC_803 4488-1585 147 µM -1.02757135881095 0.143207845739835 no 2928 0.152075751308468 4103 747204 SGTC_474 dl-dihydrosphingosine 5 µM -1.0284808355373 0.142997489527021 no 2929 0.151861850574242 4140 3058739 A sphingolipid protein kinase C inhibitor. SGTC_732 3970-1727 52.7 µM -1.03157078164401 0.142284364817592 no 2930 0.151136616954985 4194 1275699 SGTC_2784 7567673 72.73 µM -1.03272579074015 0.14201842063114 no 2931 0.150866120247445 4096 3471247 SGTC_770 0389-1121 67.2 µM -1.03824852303558 0.140751448567962 no 2932 0.14957718375816 4224 6753108 SGTC_2474 5321570 43.32 µM -1.04399564711694 0.139441165530652 no 2933 0.148243701774191 4142 2841384 SGTC_2089 5281248 129.67 µM -1.04500793968016 0.139211235846134 no 2934 0.148009649993793 4118 2737878 SGTC_1933 st074711 15.9 µM -1.04505751202286 0.139199982734784 no 2935 0.147998194747241 4124 17250958 SGTC_1284 0929-0043 16 µM -1.05363252661287 0.137262732431896 no 2936 0.146025595700398 4135 1239883 SGTC_3096 9117468 49.47 µM -1.05394837606985 0.137191729705054 no 2937 0.145953276474825 4038 41316311 SGTC_3039 9090270 49.47 µM -1.0547940541391 0.137001745423746 no 2938 0.145759762274805 4166 17173750 SGTC_2689 tacrolimus 100 µM -1.05574138547141 0.136789137994685 no 2939 0.145543191933121 4167 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). SGTC_1972 st070201 17.4 µM -1.05645024470078 0.136630197920048 no 2940 0.145381280537893 4152 2829099 SGTC_193 1273-0060 1.558 µM -1.05968425800026 0.135906671658845 no 2941 0.14464413339957 3959 2847393 YHR072W ERG7 SGTC_2061 5245884 80.95 µM -1.06150503765194 0.135500475959652 no 2942 0.144230222368916 4115 573863 SGTC_605 1315-0399 119 µM -1.06244141296231 0.135291905276494 no 2943 0.14401767087686 4227 24020461 SGTC_1213 1315-0166 115 µM -1.0628704427342 0.135196415619181 no 2944 0.143920354336114 4231 768401 SGTC_3291 9121177 71.43 µM -1.06408135549838 0.13492715065604 no 2945 0.143645923110438 4165 17015612 SGTC_185 k048-0037 25.491 µM -1.06434283654387 0.134869054676492 no 2946 0.143586709609538 4204 6827589 SGTC_668 1682-0499 62.6 µM -1.06462672862139 0.134805998836037 no 2947 0.143522439690592 4137 682214 SGTC_3103 9120822 49.47 µM -1.06872737308652 0.1338974523504 no 2948 0.142596266706668 4192 17141819 SGTC_1270 0831-1170 17.3 µM -1.07031187938749 0.133547515960828 no 2949 0.142239474512854 4190 6764716 SGTC_3247 9135149 49.47 µM -1.07067475576704 0.13346746372226 no 2950 0.142157848685779 4178 8934436 YOR116C RPO31 SGTC_485 niflumic acid 177 µM -1.07073326103682 0.133454560274397 no 2951 0.142144691411773 4219 4488 A COX2 inhibitor. SGTC_1188 1403-0014 4.57 µM -1.07123887459804 0.133343081997907 no 2952 0.1420310181107 4151 9614867 SGTC_2756 carbadox 75.1 µM -1.07295002764657 0.132966280314992 no 2953 0.141646769045893 4130 2553 A substituted quinoxaline antibiotic. YLR208W SEC13 SGTC_2213 7173844 200 µM -1.07433599183425 0.132661624112327 no 2954 0.141336059616862 4122 892728 SGTC_3044 9093193 49.47 µM -1.07548775051423 0.132408815956189 no 2955 0.141078206772858 4199 25236277 SGTC_1983 st071813 46.9 µM -1.0758272331989 0.132334363747532 no 2956 0.141002265152577 4229 11838595 SGTC_600 1495-0418 41.6 µM -1.07621427439593 0.132249516651655 no 2957 0.140915718614985 4156 5377768 SGTC_559 1550-0661 158 µM -1.07795166017492 0.131869109315567 no 2958 0.140527664630859 4224 5830875 SGTC_1243 0416-0003 5.65 µM -1.07914979860757 0.131607212442687 no 2959 0.140260477316653 4153 2141977 SGTC_3033 9090887 49.47 µM -1.08010245757616 0.131399230416021 no 2960 0.140048278813108 4194 19325384 SGTC_1129 3453-1384 223 µM -1.0821881032 0.130944690246973 no 2961 0.13958447684105 4272 1084452 SGTC_2176 5809774 33.9695 µM -1.08274722068711 0.130823022535003 no 2962 0.139460319086113 4125 2870539 SGTC_26 0302-0163 425.158 µM -1.08303875676609 0.13075961333193 no 2963 0.139395610323741 4232 3100915 SGTC_2638 epoxomicin 18 µM -1.08470360291173 0.130397915767893 no 2964 0.139026475810237 4159 9915668 A protesome inhibitor. SGTC_2950 9072895 21.46 µM -1.08686905970624 0.129928493919058 no 2965 0.138547340936258 4148 17332245 SGTC_3169 9102970 49.47 µM -1.08710407648441 0.129877618082175 no 2966 0.13849540824529 4242 17027839 SGTC_2996 9066192 71.4286 µM -1.0932332143425 0.128555666379386 no 2967 0.137145708683204 4219 6472854 SGTC_671 0560-0003 407 µM -1.09983445950971 0.127142366377843 no 2968 0.135702127586085 4105 3238678 SGTC_881 0833-0569 170 µM -1.10310964601922 0.126445189414641 no 2969 0.134989776194972 4215 5418700 SGTC_2619 obliquin 87.91 µM -1.10343589475322 0.12637588819201 no 2970 0.134918957986958 4160 6708593 A bioactive alkalod. YER133W GLC7 SGTC_1847 st056231 15 µM -1.1040597813636 0.12624343692404 no 2971 0.134783603053768 4197 5393180 SGTC_2263 7948595 193.29 µM -1.10599120480182 0.125834008794148 no 2972 0.134365163110963 4192 2971371 SGTC_3112 9123419 49.47 µM -1.10948895836829 0.125094905197896 no 2973 0.133609652564163 4253 17015854 SGTC_1206 3978-0017 132 µM -1.11029813979675 0.124924351343055 no 2974 0.133435287219052 4289 3873677 SGTC_328 k915-0120 63.5 µM -1.11082927453141 0.124812490662148 no 2975 0.133320921506067 4187 6624543 SGTC_2137 5261020 140 µM -1.11219845038995 0.124524455495457 no 2976 0.13302641702269 4162 763655 SGTC_3244 9134489 49.47 µM -1.11626286344996 0.123672158540413 no 2977 0.132154816434863 4215 16584271 SGTC_1408 3909-7976 48.8 µM -1.11975095526042 0.122943978462399 no 2978 0.131409952193581 4262 24152374 SGTC_2502 avocadyne acetate 18.59 µM -1.12115519308976 0.122651677718092 no 2979 0.13111090425016 4152 3952079 SGTC_2430 5571206 200 µM -1.12147611363603 0.122584944625244 no 2980 0.131042626725552 4223 1731771 SGTC_378 3970-0959 8.33 µM -1.12158319061364 0.122562684415382 no 2981 0.131019851005024 4248 6615653 SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM -1.12247782820021 0.122376809233735 no 2982 0.130829664737281 4195 803109 SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM -1.12279571708745 0.122310810427417 no 2983 0.130762132389008 4270 368090 SGTC_1629 st005085 44.9 µM -1.12467335608266 0.121921492211488 no 2984 0.13036373807083 4172 24207091 SGTC_3056 9094900 49.47 µM -1.12791797307925 0.121250791891683 no 2985 0.129677281325323 4204 25236784 SGTC_1683 st010134 710 nM -1.12962904142517 0.120898140901403 no 2986 0.129316284233282 4207 3818134 SGTC_2376 9072922 81.32 µM -1.13234765848462 0.120339319777582 no 2987 0.128744150464894 4235 17087968 SGTC_2518 prenyletin 46.28 µM -1.1331557288933 0.120173569459125 no 2988 0.128574430897922 4207 3873459 A coumarin with calcium channel inhibitory activity. SGTC_2513 baicalein 25.65 µM -1.13480418253945 0.119835939820785 no 2989 0.128228686705799 4240 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2 SGTC_3303 9125618 40.5795 µM -1.13563918447552 0.119665173507104 no 2990 0.12805380122167 4234 22695467 SGTC_3352 9151559 45.5865 µM -1.139145517055 0.118949966839952 no 2991 0.12732123271681 4234 17159339 SGTC_1226 3909-7979 35.4 µM -1.13999438469986 0.118777273257658 no 2992 0.127144320277305 4225 6615510 SGTC_2919 7978188 46.38 µM -1.141504139204 0.118470566660374 no 2993 0.126830095244992 4243 2980291 SGTC_1031 k035-0009 16 µM -1.14462044666851 0.117839260019908 no 2994 0.126183209321395 4303 5180959 SGTC_608 k048-0125 159 µM -1.14712567273871 0.117333476055268 no 2995 0.125664842432531 4276 6817652 YLR060W | YFL022C FRS1 | FRS2 SGTC_3187 9109394 49.47 µM -1.1493972896019 0.116876186634062 no 2996 0.125196098584889 4249 17098090 SGTC_2745 rifampicin 24.3 µM -1.15051219705768 0.116652212143535 no 2997 0.124966486750004 4299 25141428 Inhibits bacterial DNA-dependent RNA polymerase. SGTC_1663 st014140 55.4 µM -1.15078557027705 0.116597340510446 no 2998 0.124910231295433 4309 4207120 SGTC_2882 9058044 58.44 µM -1.15080670558501 0.116593098981421 no 2999 0.124905882753521 4274 18076804 SGTC_2717 st081029 62.2815 µM -1.15315313645878 0.116122886854461 no 3000 0.124423767428909 4217 5292846 SGTC_1144 3486-0183 12.5 µM -1.15529531823497 0.11569478184978 no 3001 0.123984756258855 4238 6744069 SGTC_503 tyrphostin 8 294 µM -1.15597311782979 0.115559560532526 no 3002 0.12384607642654 4249 92970 A tyrosine kinase inhibitor. YOR207C RET1 SGTC_55 0767-0285 6.563 µM -1.15810348467852 0.115135282607423 no 3003 0.123410904063758 4163 3116166 SGTC_2866 9034245 58.44 µM -1.15850121933321 0.115056193731239 no 3004 0.123329777180753 4225 6462273 SGTC_575 k072-0246 11.9 µM -1.16104979043073 0.114550331415771 no 3005 0.122810825864127 4328 6796779 SGTC_2858 9025781 8.96 µM -1.16425607780455 0.113916171086701 no 3006 0.12216012524351 4144 4894980 YPL153C RAD53 SGTC_1573 oleylamine 1.06 µM -1.16498777438403 0.113771802638679 no 3007 0.12201197079828 4251 5356789 An amine of the fatty acid oleic acid. SGTC_3004 9076122 71.4286 µM -1.16575934462718 0.113619708166246 no 3008 0.121855879446493 4273 44782551 SGTC_2658 polymyxin b sulfate 77.05 µM -1.16787222944429 0.113203951479378 no 3009 0.121429153712299 4279 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides.  YIL048W NEO1 SGTC_2208 7283366 200 µM -1.17041659178816 0.112704734014132 no 3010 0.120916680938959 4239 898663 SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM -1.17074391927005 0.112640624923638 no 3011 0.120850862926625 4234 6312947 SGTC_416 estradiol valerate 100 µM -1.17099897832915 0.112590688102288 no 3012 0.120799593909469 4278 13791 A steroid. SGTC_1160 4092-0570 10.5 µM -1.17107350590327 0.112576099682353 no 3013 0.12078461613042 4251 4994975 SGTC_2296 7971656 126.45 µM -1.1725318663182 0.11229090418328 no 3014 0.120491792989412 4287 666570 SGTC_344 k064-0035 6.43 µM -1.17281166144745 0.112236246811171 no 3015 0.120435670332965 4202 5088750 SGTC_61 0978-8327 98.565 µM -1.17324223011078 0.112152173303316 no 3016 0.120349340763962 4175 6150059 YHR072W ERG7 SGTC_1941 st076221 61.8 µM -1.17762014159375 0.111299890440671 no 3017 0.119474038217039 4146 2828568 SGTC_3334 9142812 21.919 µM -1.17862716900029 0.111104502043244 no 3018 0.119273334070096 4264 45283678 SGTC_33 0986-0033 35.816 µM -1.18259353681698 0.110337317129627 no 3019 0.118485137613233 4237 2848082 SGTC_1256 0570-0116 285 µM -1.1837954606284 0.110105589715553 no 3020 0.118247019789658 4269 410638 SGTC_3204 9114183 49.47 µM -1.18503025863527 0.109867888046153 no 3021 0.118002741706884 4252 17027248 SGTC_3158 9100007 49.47 µM -1.18537130416333 0.109802300893338 no 3022 0.117935336180769 4289 19297233 SGTC_389 tpck 16.7 µM -1.18791026358587 0.109314911735297 no 3023 0.117434382821568 4309 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.  SGTC_1721 st082152 9.2685 µM -1.18810609454264 0.10927738387631 no 3024 0.117395806773314 4202 5296051 SGTC_410 α-linolenic acid 100 µM -1.18826558738392 0.10924682647337 no 3025 0.117364395473029 4313 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_2923 7992654 58.14 µM -1.18855667339384 0.109191072823074 no 3026 0.117307082915656 4273 2985126 SGTC_250 brefeldin a 552.239 µM -1.19110913857825 0.108703057600368 no 3027 0.11680537138334 4157 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.  SGTC_2158 5657123 3.6195 µM -1.19168434438624 0.108593298787432 no 3028 0.116692519490243 4243 2858827 SGTC_2451 5856223 45.7 µM -1.19489576479308 0.107981971278138 no 3029 0.116063878906509 4256 2179896 SGTC_2676 harmalol 100 µM -1.19779839218264 0.107431561370112 no 3030 0.115497756650843 4241 5459187 A monoamine oxidase inhibitor SGTC_1766 st045414 44.774 µM -1.19974113133287 0.107064301435979 no 3031 0.115119946714977 4291 253960 SGTC_1251 0490-5699 265 µM -1.20039501886983 0.106940892926667 no 3032 0.114992981245319 4327 3883818 SGTC_2192 5915882 198.485 µM -1.20245261288699 0.106553231791703 no 3033 0.114594107643733 4253 2876149 SGTC_2881 9058953 51.95 µM -1.20383300732682 0.106293727697026 no 3034 0.114327064627517 4235 17122249 SGTC_439 amiodarone 34.4 µM -1.20529495841412 0.106019389573934 no 3035 0.114044727598334 4158 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1 SGTC_2186 6124449 200 µM -1.20695589174614 0.105708333256117 no 3036 0.113724565565544 4292 3834182 YLR033W RSC58 SGTC_2716 st080858 38.6235 µM -1.21021021791308 0.105100783414746 no 3037 0.113099119132066 4261 5296050 SGTC_1614 st002383 48.6 µM -1.21229179005232 0.104713502462384 no 3038 0.112700352733903 4323 1947235 SGTC_1739 st037196 92.5 µM -1.21349666547664 0.104489805612513 no 3039 0.112469994243434 4342 612214 SGTC_813 k007-0158 173 µM -1.21440049129817 0.104322228969786 no 3040 0.112297413954038 4294 6523916 SGTC_2127 5253358 187.912 µM -1.21758758208429 0.103732870925654 no 3041 0.111690367862731 4202 20612 SGTC_917 harmaline 728.087 nM -1.21779557365361 0.103694493177642 no 3042 0.111650833405562 4242 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7 SGTC_3305 9127027 53.8275 µM -1.21851142149338 0.103562486622412 no 3043 0.111514843571229 4242 41905295 SGTC_1662 st014054 52 µM -1.21853332948314 0.103558448584267 no 3044 0.111510683573716 4341 2838777 SGTC_1254 0550-0035 264 µM -1.21871305215835 0.103525326762983 no 3045 0.111476561134944 4309 15121435 SGTC_114 0364-0001 490.298 µM -1.22063094671876 0.103172348882635 no 3046 0.111112891838424 4338 4003655 SGTC_523 1934-0222 13.7 µM -1.22102147060639 0.103100582346816 no 3047 0.111038945306287 4258 1361595 SGTC_2557 derrustone 83.84 µM -1.22329222831878 0.102684003674319 no 3048 0.110609670735521 4274 629853 An antioxidant. SGTC_2903 5923464 63.88 µM -1.22708712357507 0.101990549443263 no 3049 0.109894923484269 4318 2876576 SGTC_2581 avocatin a 64 µM -1.22814996220788 0.101796945573091 no 3050 0.109695339242742 4263 6710728 A skin care supplement. SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM -1.2281727401052 0.101792799341799 no 3051 0.10969106476485 4268 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1 SGTC_652 0437-0092 114 µM -1.22988228326683 0.101481964161365 no 3052 0.109370594763135 4246 3091274 SGTC_198 3454-2873 16.191 µM -1.23037281252125 0.10139290217189 no 3053 0.109278764721119 4307 710957 SGTC_561 1550-0330 72.9 µM -1.2327812186801 0.100956450581996 no 3054 0.108828700141902 4261 6812934 SGTC_3228 9131799 49.47 µM -1.2327872238487 0.100955364039252 no 3055 0.10882757960995 4341 17015818 SGTC_2936 9038235 15.59 µM -1.23542935805945 0.100478137205738 no 3056 0.108335376102136 4253 4749415 SGTC_1783 st039459 87.517 µM -1.23597857923703 0.100379142902906 no 3057 0.10823326304954 4404 729761 SGTC_654 1124-0271 80.9 µM -1.23636810767158 0.100308975552153 no 3058 0.108160882611654 4293 5403748 SGTC_1457 k015-0032 57.3 µM -1.23925059289755 0.0997908540056069 no 3059 0.107626354788362 4310 4302660 SGTC_2423 st077119 87.2 µM -1.24172615588142 0.0993474387806466 no 3060 0.107168808059884 4244 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae). SGTC_1636 st007707 68.9 µM -1.24265480335039 0.0991814743642442 no 3061 0.106997532780067 4336 403051 SGTC_2531 methyl deoxycholate 70.07 µM -1.2441920271129 0.0989071932006252 no 3062 0.106714448703838 4278 16667744 Haematoxylin. SGTC_1802 st050112 57.9 µM -1.24760091059765 0.0983009393405104 no 3063 0.106088622425793 4321 4662563 SGTC_699 0375-0592 111 µM -1.24782316057885 0.0982615079443419 no 3064 0.106047912513999 4391 762578 SGTC_1541 2',3',6-trimethoxyflavone 64 µM -1.24846329380209 0.0981480008121452 no 3065 0.105930721285224 4423 688801 SGTC_2311 7694451 200 µM -1.25151729349913 0.0976077939242973 no 3066 0.105372904143957 4318 2163142 SGTC_2096 5468907 200 µM -1.25353912374171 0.0972513638683457 no 3067 0.105004785036327 4324 759785 SGTC_2983 9022671 12.99 µM -1.25968976414612 0.0961729356709288 no 3068 0.103890649660501 4327 6405161 SGTC_202 3594-0513 34.79 µM -1.26371436151467 0.0954720533400554 no 3069 0.103166284253568 4401 708429 SGTC_2029 5175081 200 µM -1.26881877267441 0.0945885390119492 no 3070 0.102252854028819 4296 1380876 SGTC_1695 st026914 34.495 µM -1.2689654352755 0.0945632427947147 no 3071 0.102226696093469 4331 3289191 SGTC_2522 biochanin a 4.94 µM -1.26991146530646 0.0944001923180326 no 3072 0.102058084330133 4353 5280373 A possible chelator. SGTC_747 3448-8087 38.7 µM -1.27200301480073 0.0940404449122551 no 3073 0.1016860240513 4412 5168703 SGTC_2785 7756463 72.73 µM -1.27274537622476 0.0939130019769172 no 3074 0.101554205066621 4317 2201551 SGTC_1697 st025554 27.742 µM -1.27405105119963 0.0936891629990024 no 3075 0.101322662110071 4359 1269519 SGTC_1805 st050013 60.3 µM -1.27505133208059 0.0935179460559479 no 3076 0.101145536836366 4297 4037144 SGTC_1360 1598-0022 39.8 µM -1.2757145332737 0.0934045541289611 no 3077 0.101028224599815 4381 761525 SGTC_2962 9082311 13.18 µM -1.27832019950907 0.0929600293413086 no 3078 0.100568274206874 4316 16459453 SGTC_1345 1488-0192 31.4 µM -1.2797407327831 0.0927183470716891 no 3079 0.100318166993661 4394 658348 SGTC_2187 6125751 200 µM -1.27985168206713 0.0926994903106861 no 3080 0.100298651757596 4366 874498 SGTC_1037 k284-1091 78.7 µM -1.28302808603438 0.0921608361669427 no 3081 0.0997411182211932 4332 3334711 SGTC_3319 9138450 16.7555 µM -1.28525248145047 0.0917850053095871 no 3082 0.099352034749415 4283 2029690 SGTC_1676 st018489 23.4 µM -1.28848228083822 0.0912413255221268 no 3083 0.098789066501324 4366 3696235 SGTC_1192 1488-0095 21.4 µM -1.28879084866044 0.09118950879648 no 3084 0.0987354041836599 4379 915875 SGTC_769 0302-0231 76 µM -1.2939635863293 0.0903241152313915 no 3085 0.0978389994619464 4266 571869 YER009W NTF2 SGTC_125 0133-0007 11.75 µM -1.29515511872942 0.0901256402062704 no 3086 0.097633361935809 4441 26541 SGTC_1383 3049-0032 20.7 µM -1.29645095468304 0.0899101591932133 no 3087 0.0974100833960521 4424 712864 SGTC_1668 st014914 51.6 µM -1.29691223192039 0.0898335471427547 no 3088 0.0973306936560798 4375 2839556 SGTC_902 1120-0002 2.07 µM -1.29733685843497 0.0897630651950137 no 3089 0.0972576537885654 4353 3280475 SGTC_1649 st011737 51.3 µM -1.30097767991277 0.0891604272601467 no 3090 0.0966330474096846 4383 1761035 SGTC_402 epigallocatechin gallate 10 µM -1.30244975922492 0.08891762161227 no 3091 0.0963813409907807 4317 65064 An antioxidant. SGTC_3001 9076041 71.4286 µM -1.30268276631393 0.0888792344506607 no 3092 0.0963415440154787 4357 16004211 SGTC_2424 5537928 59.2 µM -1.30521812293993 0.0884623399284328 no 3093 0.0959092924006893 4371 5382802 SGTC_1791 st048313 56.1 µM -1.30629781803091 0.0882852461797649 no 3094 0.095725649425696 4381 1204976 SGTC_3289 9119912 71.43 µM -1.30736575635538 0.088110340857233 no 3095 0.0955442607497879 4381 17014829 SGTC_1231 0242-0792 125 µM -1.30851548302733 0.0879223292677774 no 3096 0.0953492632591097 4371 3707635 SGTC_1894 3',6'-dihydroxyflavone 78.7 µM -1.30881497966394 0.0878734025742323 no 3097 0.0952985157612696 4366 688662 SGTC_955 1216-0110 33 µM -1.31198003259866 0.0873575904015185 no 3098 0.0947634358976429 4348 3619719 SGTC_428 3448-4153 16.5 µM -1.31352222195403 0.0871070785627567 no 3099 0.094503518956581 4336 3834874 SGTC_2008 4012253 172 µM -1.31435623456364 0.0869718260298489 no 3100 0.094363175614775 4366 603940 SGTC_1709 st033179 39.1045 µM -1.31467643816466 0.0869199400375196 no 3101 0.0943093342562697 4378 573381 SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM -1.31555053200766 0.0867784190508532 no 3102 0.0941624731195089 4380 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_1980 st071811 45.7 µM -1.32156940400804 0.0858085994423085 no 3103 0.093155788623862 4447 4974850 SGTC_1079 idarubicin 2.36 µM -1.32158238400121 0.0858065167814143 no 3104 0.0931536262876228 4396 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_1154 4088-0362 150 µM -1.32330077608915 0.0855311319384627 no 3105 0.0928676868612177 4390 6618304 SGTC_413 propylparaben 100 µM -1.32788650135875 0.0847994764785647 no 3106 0.0921078023688213 4369 7175 A pharmaceutical preservative. SGTC_2361 9034121 116 µM -1.33186187980641 0.0841690084874392 no 3107 0.091452789736779 4413 6496917 SGTC_1781 st038725 66.3 µM -1.33467825688637 0.0837244841009319 no 3108 0.0909908364381424 4378 4270275 YIL048W NEO1 SGTC_2890 9046729 58.44 µM -1.33699346923837 0.0833603840008935 no 3109 0.0906123843026344 4350 903329 SGTC_1827 berberine 7.24 µM -1.33737518785126 0.0833004677845204 no 3110 0.0905500997010888 4297 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_2928 9011484 9.79 µM -1.33775205402254 0.0832413449948549 no 3111 0.0904886380517382 4385 2994751 SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM -1.3377761293954 0.0832375691211726 no 3112 0.0904847127448771 4401 7104 SGTC_161 4065-0411 162.148 µM -1.33808504745956 0.0831891312215484 no 3113 0.0904343572162319 4382 1906281 YLR208W SEC13 SGTC_1049 3226-0134 66 µM -1.33992161962737 0.0829015968709607 no 3114 0.0901354142593632 4423 5702385 SGTC_1481 3346-2004 36 µM -1.34406160321265 0.0822561827997469 no 3115 0.0894642335608017 4479 2770522 SGTC_1579 chlormadinone acetate 49.4 µM -1.34533315450611 0.0820587124462269 no 3116 0.0892588356911286 4435 45114258 A steroidal progestin. SGTC_3330 9141424 71.43 µM -1.34908601753057 0.0814779800848054 no 3117 0.0886546694392143 4415 27261020 SGTC_899 1083-0020 478 µM -1.35601527732461 0.0804138728736948 no 3118 0.0875471536329888 4455 767123 SGTC_3090 9117696 49.47 µM -1.35615415337397 0.0803926539104829 no 3119 0.0875250628515077 4360 7923821 SGTC_3317 9138495 8.753 µM -1.35664758073179 0.0803172970367794 no 3120 0.0874466078313187 4317 17020139 SGTC_3082 9117008 49.47 µM -1.35769766492477 0.0801571044918429 no 3121 0.0872798190273577 4437 41448529 SGTC_2886 9058944 51.95 µM -1.35773483370657 0.0801514387449914 no 3122 0.0872739197257638 4334 4949929 SGTC_1846 st056244 14.8 µM -1.3598705887017 0.0798263875233511 no 3123 0.0869354398245672 4434 5393182 SGTC_7 0192-1582 4.227 µM -1.3628988052561 0.0793672184290366 no 3124 0.0864572026571539 4462 252616 SGTC_1473 k844-0725 134 µM -1.36871963086379 0.0784902243030033 no 3125 0.0855434657647185 4448 54682906 SGTC_457 grayanotoxin iii 135 µM -1.37038286254071 0.0782409881036539 no 3126 0.0852837094238298 4251 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity. SGTC_3293 9120939 62.045 µM -1.37700655201403 0.0772543767276185 no 3127 0.0842551110731516 4410 934087 SGTC_609 0986-0026 86.3 µM -1.37704902696241 0.0772480806432824 no 3128 0.0842485452810701 4391 2848610 SGTC_1271 0832-2808 169 µM -1.37815613213086 0.0770841113190287 no 3129 0.0840775440064543 4455 3663794 SGTC_2004 4023728 41.89 µM -1.38012188001468 0.0767936234819139 no 3130 0.0837745607734565 4381 360084 YDR527W RBA50 SGTC_2269 7935389 174.42 µM -1.38017039986447 0.076786464014821 no 3131 0.0837670927320404 4404 97605 SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM -1.38124108864164 0.0766286050052105 no 3132 0.0836024225179545 4423 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_1043 0916-0009 19.3 µM -1.38322713325987 0.0763364424953703 no 3133 0.083297616258936 4439 3101130 SGTC_2212 7123476 200 µM -1.38837425300839 0.0755832068352434 no 3134 0.0825115561473334 4439 1085715 SGTC_425 3825-7017 13.1 µM -1.39318158649378 0.0748848229472724 no 3135 0.0817824432428629 4452 3397440 SGTC_3314 9135860 59.4275 µM -1.39989739236272 0.073917442494143 no 3136 0.0807720235187476 4422 25252478 SGTC_744 1594-0068 283 µM -1.40234880645679 0.0735667167144714 no 3137 0.0804055563061773 4435 668392 SGTC_1934 st074720 32.6 µM -1.4024465792452 0.0735527547156866 no 3138 0.0803909661345782 4374 17250992 SGTC_2671 danthron 100 µM -1.40588788218659 0.0730626246861993 no 3139 0.0798787100931054 4431 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin. SGTC_3095 9117207 49.47 µM -1.40705884448729 0.0728964207160859 no 3140 0.0797049702491353 4429 17015229 SGTC_2477 5967686 25.23 µM -1.40713266484552 0.0728859525131004 no 3141 0.0796940268463864 4425 776118 SGTC_3287 9117173 37.0625 µM -1.40745117037778 0.0728407995677036 no 3142 0.0796468234406782 4448 2789709 SGTC_1935 st074532 41.6 µM -1.40779821135379 0.0727916256767065 no 3143 0.0795954150862879 4400 2829742 SGTC_751 0833-0568 350 µM -1.40904749994135 0.0726148184370886 no 3144 0.0794105615900843 4450 6954252 SGTC_335 4077-0256 27.6 µM -1.40981354681514 0.0725065654194075 no 3145 0.0792973727413379 4376 3121989 SGTC_1381 2324-0066 62.1 µM -1.41022229896025 0.072448853691237 no 3146 0.0792370267107376 4464 10885928 SGTC_2870 9038528 12.99 µM -1.4150402420768 0.0717712575957933 no 3147 0.0785283487174589 4466 6463316 SGTC_683 panaxydol 45 µM -1.41606086079913 0.0716283435742949 no 3148 0.0783788430739388 4456 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis. SGTC_1615 st002656 86.5 µM -1.41990967043595 0.0710913704056195 no 3149 0.0778169901142536 4452 1584458 SGTC_283 0987-0079 11.7 µM -1.42664443308129 0.0701592030794847 no 3150 0.0768412049257033 4454 411556 SGTC_1388 3346-4487 254 µM -1.42701560726866 0.0701081030325282 no 3151 0.0767876980063276 4524 3345614 SGTC_2115 tiliquinol 12.7705 µM -1.42961795415034 0.0697506381413537 no 3152 0.0764133498323094 4439 71208 A bioactive hydroxyquinoline. SGTC_1959 st077091 55.8 µM -1.4314089472964 0.0695054389911187 no 3153 0.0761565228043179 4462 821356 YKL052C ASK1 SGTC_2915 7971052 15.16 µM -1.43335167523494 0.0692402173950493 no 3154 0.0758786805916098 4385 5741558 SGTC_1406 3909-7906 11.9 µM -1.43751513999734 0.0686744471002663 no 3155 0.0752858370150049 4488 X1406 SGTC_1398 3558-0053 112 µM -1.43981997420876 0.0683627815744883 no 3156 0.0749591692775668 4418 4532369 SGTC_872 0588-0139 234 µM -1.4461809726 0.0675082931865142 no 3157 0.074063224541987 4429 2047100 SGTC_1532 4',5'-dihydroxyflavone 78.7 µM -1.44845364991891 0.0672050081573494 no 3158 0.0737451098915433 4512 165521 SGTC_1259 0671-0132 43 µM -1.45032095050531 0.066956609253467 no 3159 0.0734845197109549 4406 X1259 SGTC_1764 st044502 93.5 µM -1.45384507760415 0.0664897455437786 no 3160 0.0729946313385978 4492 8407 SGTC_1335 1486-0900 202 µM -1.45721088293835 0.066046212359368 no 3161 0.0725290887026668 4465 X1335 SGTC_2378 9074213 121.43 µM -1.45750792553625 0.0660071795411338 no 3162 0.0724881126092137 4435 657714 SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM -1.4610503648149 0.0655430625533828 no 3163 0.0720008101111363 4497 6710655 SGTC_1589 2',5'-dimethoxyflavone 47.2 µM -1.46206677970634 0.0654103640087431 no 3164 0.0718614555216788 4481 688667 SGTC_277 nystatin 15.5 µM -1.46663293735815 0.0648167964096525 no 3165 0.0712379674955527 4495 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_1313 1220-0047 237 µM -1.46678489429042 0.0647971152476814 no 3166 0.071217290100308 4466 3528706 SGTC_2113 5491891 107.031 µM -1.46697121391034 0.0647729898314277 no 3167 0.0711919431240968 4473 789979 SGTC_2302 7771753 200 µM -1.46732063420573 0.0647277642880417 no 3168 0.0711444265597268 4453 2203047 SGTC_3240 9133527 49.47 µM -1.4700887572431 0.0643703516642554 no 3169 0.0707688584419566 4449 17617455 SGTC_1371 2421-0008 32.7 µM -1.47468831262439 0.0637798629143201 no 3170 0.0701481798274586 4474 2827552 SGTC_341 1486-1430 230 µM -1.48990704549789 0.0618560905583619 no 3171 0.0681243393954772 4444 2054753 YPL210C SRP72 SGTC_932 2857-0803 154 µM -1.49017407440101 0.0618227447812091 no 3172 0.0680892356462906 4488 674898 SGTC_2199 6590217 200 µM -1.49973369189186 0.0606381860417472 no 3173 0.0668416997442826 4451 703109 SGTC_3135 9127742 49.47 µM -1.50315828691792 0.0602181805544732 no 3174 0.0663991156219565 4548 3643468 SGTC_232 clozapine 119 µM -1.50748479665548 0.0596908206741225 no 3175 0.0658432189624176 4526 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_1399 3562-5772 25 µM -1.51343597697051 0.0589713494310158 no 3176 0.0650844761124086 4509 23847490 SGTC_1161 k007-0610 110 µM -1.51936011517471 0.0582619224542074 no 3177 0.0643359378251023 4436 5843850 SGTC_1936 st074407 74.3 µM -1.52416505811324 0.0576914597746196 no 3178 0.0637337421143635 4537 809813 SGTC_1096 rimcazole 32.2 µM -1.53829544559646 0.0560392699473977 no 3179 0.0619881964114246 4463 18528119 A dopamine reuptake inhibitor. SGTC_2730 imipramine 71.33 µM -1.54488883009799 0.0552812198043151 no 3180 0.061186577856456 4474 3696 A tricyclic antidepressant. SGTC_1416 3966-0321 25.3 µM -1.54743226889418 0.05499097096152 no 3181 0.0608795225384316 4561 582530 YLR208W SEC13 SGTC_3248 9135562 49.47 µM -1.54972665545236 0.0547301774549388 no 3182 0.0606035687578652 4522 17650701 SGTC_593 1203-0218 61.7 µM -1.55469162602947 0.0541691772317922 no 3183 0.0600097649610115 4565 3666956 SGTC_2741 miltefosine 3.04 µM -1.55517524331914 0.0541147766240731 no 3184 0.0599521693505465 4569 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis. SGTC_2682 pyrogallin 40.03 µM -1.55728718744925 0.0538777171197229 no 3185 0.059701158008862 4531 822798 An ATP competetive kinase inhibitor. SGTC_167 3672-0051 66.205 µM -1.55773204091921 0.0538278886229687 no 3186 0.0596483908858603 4441 3237971 SGTC_116 0155-0182 31.788 µM -1.56207219922113 0.0533436556379122 no 3187 0.0591354906361899 4396 771486 SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM -1.56450969524776 0.0530732211175174 no 3188 0.0588489589567058 4512 689007 SGTC_314 1671-0008 2.74 µM -1.56598083904635 0.0529105279326571 no 3189 0.0586765514851332 4399 3913060 SGTC_2150 5556613 200 µM -1.56697770298964 0.0528005101820922 no 3190 0.0585599517306507 4560 743190 SGTC_1635 st007035 42.4 µM -1.56747859099389 0.052745298795481 no 3191 0.0585014332869591 4481 3716403 SGTC_1610 st001799 48.1 µM -1.56907942806758 0.0525691504018347 no 3192 0.0583147162985957 4494 621897 SGTC_2862 9027634 71.43 µM -1.57145188438544 0.0523089558101537 no 3193 0.0580388611749885 4492 5012562 SGTC_1693 xanthone 101.9 µM -1.57162759788049 0.0522897255166098 no 3194 0.0580184711116827 4573 7020 An insecticide. SGTC_1511 0906-3109 28.5 µM -1.57176973186744 0.0522741743117734 no 3195 0.0580019817849946 4539 2882180 SGTC_333 3486-0131 40.1 µM -1.57607085738621 0.0518053131304687 no 3196 0.0575047371767482 4538 6744690 SGTC_1441 4106-0040 13 µM -1.57928383380646 0.0514572557117327 no 3197 0.0571354841109594 4586 2904180 SGTC_1099 5-nonyloxytryptamine 2.85 µM -1.58372140234374 0.0509796008406159 no 3198 0.0566285660821295 4549 23581825 A 5-HT1D beta serotonin receptor agonist. SGTC_2088 5278280 127.392 µM -1.58540619848571 0.0507991782760362 no 3199 0.0564370368819848 4567 791502 SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM -1.58964454587621 0.0503475472602129 no 3200 0.0559574750164825 4457 5355888 SGTC_14 0354-0009 295 µM -1.59304473400344 0.0499875471174244 no 3201 0.0555750780057404 4641 1713507 SGTC_935 2996-0153 430 µM -1.593151723804 0.0499762528062805 no 3202 0.0555630791175803 4551 23738523 SGTC_1400 3771-8998 51.5 µM -1.60206546424306 0.0490424048879326 no 3203 0.0545705669908109 4508 670767 SGTC_3177 9107506 49.47 µM -1.62181212527578 0.0470232847057329 no 3204 0.0524217907045855 4532 8897194 SGTC_266 formosanin C 406 nM -1.62394039771308 0.0468097043054449 no 3205 0.0521942648309056 4410 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1 SGTC_2252 omeprazole 400 µM -1.62957025213301 0.0462484768877763 no 3206 0.0515961779313978 4596 4594 A proton pump inhibitor. SGTC_540 1187-0821 17.3 µM -1.63285200614126 0.0459238272117802 no 3207 0.0512500630817965 4487 847520 SGTC_3199 9111318 49.47 µM -1.63596960414227 0.0456171152321516 no 3208 0.0509229745360059 4483 8548020 SGTC_1960 st011366 51.8 µM -1.64483177961097 0.0447542336226898 no 3209 0.0500022532799389 4595 3972846 SGTC_3148 9097893 49.47 µM -1.65069552369053 0.0441905600125482 no 3210 0.0494003811595872 4539 17174100 SGTC_937 3122-0005 46.7 µM -1.65316337022444 0.0439550469036934 no 3211 0.0491488095554361 4547 759535 SGTC_2685 mycophenolic acid 18.85 µM -1.65470696469386 0.0438082529146208 no 3212 0.0489919768107906 4578 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_2248 tofa 1.1 µM -1.65545467718193 0.0437372886681957 no 3213 0.0489161513769444 4598 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_462 ag-879 158 µM -1.65965773600044 0.0433401070336486 no 3214 0.0484916631406808 4578 6809654 Ag-879 is a 5-Lipoxygenase inhibitor. SGTC_1667 st014849 34.6 µM -1.66141478805554 0.0431749342382978 no 3215 0.0483150848998256 4656 5348460 SGTC_1737 st035557 69.7 µM -1.66210921968226 0.0431097940921149 no 3216 0.0482454386586714 4419 5716916 SGTC_1169 aniline yellow 25.8 µM -1.66577375047285 0.0427673618318217 no 3217 0.0478792431361531 4522 6051 A DNA damaging agent. SGTC_2020 4017018 200 µM -1.66712114995716 0.042642008184362 no 3218 0.0477451586956027 4598 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope. SGTC_3127 9126946 49.47 µM -1.66725674454269 0.0426294097778649 no 3219 0.0477316818722648 4525 27243249 SGTC_2667 digitoxin 100 µM -1.66753602277916 0.042603470873602 no 3220 0.0477039338471495 4546 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_785 1270-0111 65.3 µM -1.6699323590048 0.0423814272613801 no 3221 0.0474663735981806 4495 6741994 SGTC_2201 6605497 169.863 µM -1.67330215909689 0.0420707676041612 no 3222 0.0471339138192624 4553 670741 SGTC_327 1273-0057 3.96 µM -1.67508927752659 0.0419067637627926 no 3223 0.0469583582123899 4496 3108138 SGTC_2094 5332512 191.667 µM -1.67532889450526 0.0418848135229877 no 3224 0.0469348596215183 4590 755774 SGTC_2235 salicylic acid 500 µM -1.67833483759704 0.0416102426197229 no 3225 0.0466408753599015 4643 338 A COX inhibitor and kinase inhibitor. SGTC_1637 st007924 17.4 µM -1.68034859663442 0.0414271174238512 no 3226 0.0464447555210215 4497 683336 SGTC_3059 1327-0034 3 µM -1.68163420875935 0.0413105496788166 no 3227 0.0463198964349139 4434 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_1343 1487-0095 224 µM -1.68241255080818 0.041240105923302 no 3228 0.0462444346576306 4574 4560101 YGL055W OLE1 SGTC_3159 9100096 49.47 µM -1.69001781800984 0.0405569043734104 no 3229 0.0455122729334767 4540 25236875 SGTC_1201 1889-3372 45.9 µM -1.69180668910479 0.0403975472640882 no 3230 0.0453414188948459 4486 5392199 SGTC_3106 9121286 49.47 µM -1.69196591834971 0.0403833874015405 no 3231 0.0453262360404305 4536 15943471 SGTC_745 0469-0705 296 µM -1.69720996278542 0.0399192951375629 no 3232 0.0448284861187073 4614 3486736 SGTC_968 1309-0633 340 µM -1.69951549533488 0.0397166344124516 no 3233 0.0446110487445512 4612 3761976 SGTC_2796 7949634 45.45 µM -1.70362947681127 0.0393570861888922 no 3234 0.044225165476891 4556 2971588 SGTC_446 go6976 132 µM -1.70514101853845 0.0392256496104485 no 3235 0.0440840635475692 4598 3501 A protein kinase C inhibitor. SGTC_2140 5586273 200 µM -1.71019760281797 0.0387885471216176 no 3236 0.0436146694252519 4583 854421 SGTC_1014 4130-3005 69.3 µM -1.7120938380465 0.0386256586214679 no 3237 0.0434396883794814 4597 743608 SGTC_2856 9022925 19.48 µM -1.7270738833999 0.0373583614116185 no 3238 0.0420771976507623 4594 4944862 SGTC_3073 9114972 49.47 µM -1.73501137594116 0.0367007478242959 no 3239 0.0413693951376031 4610 41905075 SGTC_502 l-744,832 89.3 µM -1.75292376775531 0.0352514814413269 no 3240 0.0398075466225452 4618 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.  SGTC_1040 k898-0338 155 µM -1.76650356458059 0.0341843283865972 no 3241 0.0386557020384001 4599 20969351 SGTC_2295 7971645 200 µM -1.77507928918466 0.0335242001264318 no 3242 0.0379423980770571 4648 2978226 YKL099C UTP11 SGTC_1106 tegaserod maleate 11.7 µM -1.78859544911669 0.0325051048756346 no 3243 0.0368399956546961 4630 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation. SGTC_2255 7941087 197.44 µM -1.79102462867235 0.0323246860385433 no 3244 0.0366446714299564 4682 935561 SGTC_368 fentichlor 4.58 µM -1.79261348945102 0.0322071265747686 no 3245 0.0365173739796785 4614 7329 A pesticide. SGTC_1210 3013-0140 750 nM -1.8124349561454 0.030769981030667 no 3246 0.0349595078422053 4652 905973 SGTC_340 k038-0059 454 µM -1.81249075832145 0.0307660113278095 no 3247 0.0349552003170528 4621 23733424 SGTC_409 arachidonic acid 100 µM -1.81272305785084 0.0307494903617478 no 3248 0.0349372731516227 4643 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes. SGTC_2914 7968218 45.32 µM -1.8141526488298 0.0306479805546957 no 3249 0.0348271139186708 4618 2977111 SGTC_2959 9079155 11 µM -1.82816380369843 0.0296677137496819 no 3250 0.0337624857914761 4635 16189457 SGTC_370 0180-0345 38.7 µM -1.82966925394435 0.029563952940071 no 3251 0.0336497055507672 4506 3989527 SGTC_2262 9014885 67.46 µM -1.83105846847906 0.0294684708932472 no 3252 0.0335459082976622 4679 6457424 SGTC_2032 5185112 25.99 µM -1.83151996494233 0.0294368085039088 no 3253 0.0335114852689261 4522 5718189 SGTC_1444 4112-3581 28 µM -1.83748248165316 0.0290302654582257 no 3254 0.0330693501477442 4690 2877249 SGTC_2845 9003024 42.97 µM -1.83812756182002 0.0289865629137269 no 3255 0.0330218053461559 4634 2990173 SGTC_1248 0469-0687 58.6 µM -1.84367423756782 0.0286130413134675 no 3256 0.0326153148573991 4592 4017482 SGTC_635 k038-0028 24.7 µM -1.84976772523337 0.0282073200678032 no 3257 0.0321735172442593 4642 4035102 SGTC_3183 9108214 49.47 µM -1.85782033968752 0.0276785115926634 no 3258 0.0315972658653643 4667 4974831 SGTC_3162 9099653 49.47 µM -1.85999057852717 0.0275374156238718 no 3259 0.0314434294652872 4626 25237511 SGTC_1826 st055655 41.6 µM -1.86429021659684 0.027259649292929 no 3260 0.0311404799832361 4648 676168 SGTC_871 0574-0004 149 µM -1.86843201898132 0.0269942934232044 no 3261 0.0308509387658004 4601 9551173 SGTC_117 lucigenin 22.078 µM -1.87042409779628 0.0268674353427824 no 3262 0.0307124740893165 4598 65100 An acridine derivative; a dye stuff and potential carcinogen. SGTC_1338 1486-1223 76 µM -1.87347846014252 0.026673896587648 no 3263 0.0305011722202843 4649 3444526 SGTC_2057 5236571 38.335 µM -1.87569947738534 0.0265338948954878 no 3264 0.03034827886256 4587 54684039 YBR257W POP4 SGTC_1982 st072467 71.9 µM -1.8769731022866 0.0264538893644505 no 3265 0.0302608902426107 4641 3163533 SGTC_3007 9078383 71.4286 µM -1.8779916207818 0.0263900540542926 no 3266 0.030191155687662 4647 6496995 SGTC_2708 st078559 56 µM -1.88072924803915 0.0262191119612376 no 3267 0.0300043794526749 4627 17250902 SGTC_2257 7960413 200 µM -1.88241584743259 0.0261142594296082 no 3268 0.0298897879413645 4681 2974689 YIL048W NEO1 SGTC_1020 4335-0961 93.3 µM -1.88632277161956 0.0258727201211476 no 3269 0.0296257362374181 4619 669075 SGTC_2504 purpurogallin 52.29 µM -1.88731803674347 0.0258114890864237 no 3270 0.029558780945524 4613 5281571 An antioxidant. SGTC_2151 5563267 85.4165 µM -1.89445595214644 0.0253758921985037 no 3271 0.0290822578582584 4693 5310824 SGTC_2837 9008476 45.46 µM -1.90364100286056 0.0248244432214407 no 3272 0.0284784774388429 4627 2992805 SGTC_199 4063-0024 41.6 µM -1.90462472627875 0.0247659831684583 no 3273 0.028414435038576 4698 306215 SGTC_3282 9108498 15.4605 µM -1.90881269201173 0.0245183943133851 no 3274 0.0281431294917759 4640 16459645 SGTC_1776 st049249 45.9 µM -1.91135492928727 0.0243691152250171 no 3275 0.0279794922745266 4676 1822314 SGTC_3117 9124945 49.47 µM -1.91802059572612 0.0239813295809392 no 3276 0.027554199842834 4596 17592065 SGTC_1232 0279-0259 161 µM -1.92350332983461 0.0236662619242848 no 3277 0.0272084343576376 4653 1560000 SGTC_2711 st079103 59.1 µM -1.93232392694342 0.0231666903882693 no 3278 0.0266597684873682 4624 54693780 SGTC_2476 5806916 10.51 µM -1.94089395323455 0.0226898437011189 no 3279 0.026135570804936 4624 2870194 SGTC_2506 ethyl hematommate 54.16 µM -1.96038455661501 0.0216360924470553 no 3280 0.0249754297645348 4667 3940691 An allergen. SGTC_530 4358-1714 28 µM -1.96942568860546 0.0211615061878588 no 3281 0.0244521141215646 4674 1564641 SGTC_1176 0848-0131 83.3 µM -1.98911795925189 0.0201582331846377 no 3282 0.0233440922420184 4706 6769040 SGTC_665 3914-0008 307 µM -1.99782704510915 0.0197275602920549 no 3283 0.0228677070909288 4667 1069549 SGTC_766 1391-0721 126 µM -2.01401381245698 0.018947842630171 no 3284 0.0220040416694304 4692 1020919 YIL115C NUP159 SGTC_631 k072-0230 41.5 µM -2.01920382140792 0.0187034557664069 no 3285 0.0217330196556537 4689 5773147 SGTC_2888 9058547 12.99 µM -2.02420807557469 0.0184703612911674 no 3286 0.0214743735137309 4646 16476514 SGTC_1171 0368-0077 21.4 µM -2.03094521285022 0.0181604611502823 no 3287 0.021130276304136 4677 3239779 SGTC_3189 9110682 49.47 µM -2.03965569275862 0.0177663674863447 no 3288 0.0206923154197178 4667 17122418 SGTC_784 4579-0127 173 µM -2.04795920622881 0.0173975026377532 no 3289 0.0202819983659289 4703 1948547 SGTC_3210 9128157 49.47 µM -2.07185888683603 0.0163721094707015 no 3290 0.0191393015391116 4631 17590849 SGTC_1664 st014217 9.02 µM -2.08207257740123 0.0159499439769702 no 3291 0.0186679204581794 4738 3982782 SGTC_2298 7976326 193.81 µM -2.08256455318627 0.0159298467728307 no 3292 0.0186454665272793 4684 2235818 SGTC_2884 9058502 51.95 µM -2.09655205455953 0.0153674723150661 no 3293 0.018016623663423 4695 6471554 SGTC_861 0443-0273 110 µM -2.09977589131166 0.015240301010027 no 3294 0.0178742799886178 4694 6149169 SGTC_1493 4348-0038 111 µM -2.10460764596614 0.0150513949559168 no 3295 0.0176627377602407 4712 800424 SGTC_1186 1319-0216 26 µM -2.10704008535186 0.0149570583451904 no 3296 0.0175570525319167 4732 4565136 SGTC_1436 4092-1007 8.32 µM -2.10800042641829 0.0149199539018409 no 3297 0.0175154762739053 4727 2881121 SGTC_1769 st044406 64.4 µM -2.121678090607 0.0144000228246147 no 3298 0.0169323898472144 4702 670903 SGTC_1012 4112-3522 18 µM -2.12971549608056 0.0141018325783325 no 3299 0.0165975544308142 4704 3112398 SGTC_1013 4112-3890 241 µM -2.13729226438049 0.0138256198678996 no 3300 0.0162871138238196 4704 705171 SGTC_959 1222-0044 107 µM -2.14486305078596 0.0135542982615103 no 3301 0.0159818991174731 4712 6083612 SGTC_2584 androsterone 48.74 µM -2.16404517257472 0.0128873362065571 no 3302 0.0152304413539719 4621 2754130 A steroid. SGTC_2505 galangin 7.89 µM -2.17137764107049 0.012639989512129 no 3303 0.0149513188170245 4683 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_2204 7233102 200 µM -2.17547682619395 0.01250351012142 no 3304 0.014797201426745 4748 2172480 SGTC_2052 5265182 7.135 µM -2.17555163980776 0.0125010311588604 no 3305 0.0147944013964133 4692 1239884 SGTC_1834 st055981 52.8 µM -2.20040505277202 0.0117007069047493 no 3306 0.0138890848320815 4696 471719 YDL150W RPC53 SGTC_304 1310-0298 97 µM -2.20295979844431 0.0116210172028914 no 3307 0.013798791129605 4498 1550234 SGTC_964 1287-0107 19.4 µM -2.20728459047203 0.0114871885994625 no 3308 0.0136470915882661 4712 51516812 YPR165W RHO1 SGTC_1483 3453-0561 55.9 µM -2.21641355653598 0.0112090857598337 no 3309 0.013331596049559 4750 4546991 SGTC_2595 hexamethylquercetagetin 100 µM -2.2377793132098 0.0105809816839069 no 3310 0.0126177250425571 4686 386331 SGTC_2101 5377231 179.231 µM -2.24027616438364 0.0105096198236878 no 3311 0.0125364998389507 4743 2844213 SGTC_2968 9090663 33.37 µM -2.24568964195959 0.0103563375002497 no 3312 0.0123619470506882 4685 25236811 SGTC_2697 mebhydrolin 72.4 µM -2.26884411534668 0.00972250818566551 no 3313 0.0116389035840839 4715 22530 H1 Histamine receptor antagonist. YIL048W NEO1 SGTC_2027 5150920 200 µM -2.28400693999948 0.00932604573316146 no 3314 0.0111855615411905 4722 786715 SGTC_466 geldanamycin 89.2 µM -2.30852010321483 0.00871498779768543 no 3315 0.0104851130112119 4766 5288382 HSP90 inhibitor. SGTC_1638 st008370 60.6 µM -2.30857610570381 0.00871363296570669 no 3316 0.010483557568157 4697 24207134 SGTC_2933 9026794 32.47 µM -2.32488575215021 0.00832683833696508 no 3317 0.0100390350159495 4707 17586027 SGTC_1836 st055642 81 µM -2.3339733471267 0.00811792797700196 no 3318 0.00979855878395298 4725 8571 SGTC_527 4476-4215 268 µM -2.34235758326008 0.00792928628778237 no 3319 0.00958117285462004 4740 4418754 SGTC_247 mechlorethamine 29.705 µM -2.36078098406682 0.00752825604884892 no 3320 0.00911824862049594 4763 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links. SGTC_2651 TUB2.036 5 µM -2.3760997251509 0.00720852099383346 no 3321 0.0087483666542494 4642 15992207 YFL037W TUB2 SGTC_435 c-PAF 6.7 µM -2.38042333294839 0.00712047272934803 no 3322 0.00864637952574617 4682 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase SGTC_653 0203-0016 55.2 µM -2.39658247474377 0.00679974225486415 no 3323 0.00827438437519705 4774 295302 SGTC_1010 4112-3296 15.2 µM -2.44951215749527 0.00583674442121638 no 3324 0.00715249402519089 4753 704384 SGTC_2971 9092186 9.93 µM -2.45240924718344 0.00578771354552487 no 3325 0.00709515846706299 4714 25236400 SGTC_2829 7992743 58.44 µM -2.46545730361733 0.00557138670724935 no 3326 0.00684192412655372 4716 16462845 SGTC_900 1112-0045 141 µM -2.47069906477951 0.00548652450268357 no 3327 0.00674246217700294 4732 56211 YIL048W NEO1 SGTC_1977 st070720 65.3 µM -2.47597237265318 0.00540231249754278 no 3328 0.00664369298522857 4762 682188 SGTC_2087 5276107 200 µM -2.48041114222454 0.00533232035162269 no 3329 0.00656154839518052 4758 144405 SGTC_2582 agaric acid 100 µM -2.48081730832616 0.00532595622296652 no 3330 0.00655407686196282 4499 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase. SGTC_2148 5546263 113.568 µM -2.49137198073263 0.00516292835118893 no 3331 0.00636254079197497 4773 792097 SGTC_2965 9082772 38.63 µM -2.49481121936797 0.00511077343516087 no 3332 0.0063012078815875 4748 16459634 SGTC_529 4076-0302 30.3 µM -2.52439469733535 0.00468116726861182 no 3333 0.00579488607230503 4762 5816522 SGTC_2973 9094665 17.96 µM -2.53021549101654 0.00460053531667858 no 3334 0.0056996245995704 4733 25237061 YIL048W NEO1 SGTC_2600 tangeritin 87.95 µM -2.53556258840651 0.00452755998049446 no 3335 0.00561334323617925 4730 68077 A bioactive flavone. SGTC_2083 5306046 65.942 µM -2.54524865398332 0.00439799554889478 no 3336 0.00545999735688662 4776 539837 SGTC_342 k048-0088 23.3 µM -2.61052156010379 0.00360795254999671 no 3337 0.00452021365810727 4778 6820570 SGTC_1500 4488-1866 171 µM -2.61254630685564 0.00358562480700172 no 3338 0.00449352582883427 4797 2900003 SGTC_2659 sanguinarine 24.21 µM -2.62175475860286 0.00348563616131595 no 3339 0.00437391771415502 4759 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis. SGTC_3050 9093513 49.47 µM -2.66217989829043 0.00307567635980254 no 3340 0.00388181865263029 4753 25236664 SGTC_1230 0170-0365 3.77 µM -2.66976355736882 0.00300379339754279 no 3341 0.00379523382796138 4772 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1 SGTC_2084 5306078 60.6385 µM -2.67085686593429 0.00299355607977936 no 3342 0.00378289504710115 4767 679340 SGTC_1705 st027868 56.3335 µM -2.76050650968632 0.00225374224699779 no 3343 0.00288559039213136 4775 292948 SGTC_780 0109-0199 192 µM -2.76884136936023 0.00219417270985432 no 3344 0.00281280089607176 4784 610414 SGTC_1440 4100-1550 40 µM -2.77606188397684 0.00214372509758721 no 3345 0.00275108673085232 4793 742806 SGTC_2834 9001755 58.44 µM -2.78697853688287 0.00206944881491743 no 3346 0.00266010012839447 4670 2989575 SGTC_3157 9099274 49.47 µM -2.8340507886302 0.0017751882682918 no 3347 0.00229810132895156 4780 17217662 SGTC_2056 5235370 200 µM -2.95203446459189 0.00119723257857434 no 3348 0.00157843846726889 4749 5511916 SGTC_791 1348-1292 225 µM -3.03806883718873 0.000890675850514903 yes 3349 0.00119049779152462 4788 5437054 SGTC_869 0564-0080 44.1 µM -3.05057961865108 0.000852664162793778 yes 3350 0.00114200057270499 4794 6843321 SGTC_3153 9100258 49.47 µM -3.05519233975631 0.000839029903734529 yes 3351 0.0011245811528888 4761 25236848 SGTC_1237 0330-0133 46.1 µM -3.18833410910092 0.000522166886742524 yes 3352 0.000715475455014658 4796 X1237 YHR072W ERG7 SGTC_2949 9072542 2.23 µM -3.19752356794092 0.000505027015923431 yes 3353 0.000693065419712614 4775 16457352 SGTC_249 wiskostatin 11.211 µM -3.39458460179582 0.000241988755804149 yes 3354 0.000343664001287341 4797 2775510 A n-wasp and actin depolymerizer. SGTC_740 k014-0057 261 µM -3.49911670315685 0.000161266489589491 yes 3355 0.000233401109571152 4801 4012779 SGTC_1835 st008666 49.2 µM -3.72268466724169 6.52814269967119e-05 yes 3356 9.85578204372332e-05 4805 690455