SGTCid condition conc unit YGL218W|YGL218W.score YGL218W|YGL218W.strain.pval YGL218W|YGL218W.strain.significant YGL218W|YGL218W.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene
SGTC_1750 st081859 2.357 µM 8.57763925303574 7.18982789427345e-14 yes 1 4.84200532283565e-18 57 5291695
SGTC_236 1509-0011 5.31 µM 7.35390834226394 1.19193674265978e-10 yes 2 9.62468775292608e-14 261 3107280
SGTC_2688 kanamycin b 96.69 µM 6.0515687597417 9.55062599647497e-08 yes 3 7.17210172439791e-10 158 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis.
SGTC_10 0279-0212 42.575 µM 5.86152746414122 2.28541794640373e-07 yes 4 2.29314300554976e-09 31 39851 YBR002C RER2
SGTC_684 1140-0066 328 µM 5.62648779998977 6.48513497216675e-07 yes 5 9.19578939411351e-09 4 6813534
SGTC_314 1671-0008 2.74 µM 5.35200797050936 2.08423559815561e-06 yes 6 4.34917832395929e-08 13 3913060
SGTC_680 0417-1641 114 µM 5.16606311819089 4.45695422491668e-06 yes 7 1.19538042918197e-07 3 2835990
SGTC_1883 5-benzylidenerhodanine 20 µM 5.1482480254699 4.78736998598199e-06 yes 8 1.3146534053558e-07 27 1273210
SGTC_28 pentachloropyridine N-oxide 1.606 µM 5.03630351123672 7.46442177418135e-06 yes 9 2.37303906486229e-07 28 140250 A respiratory chain inhibitor.
SGTC_3044 9093193 49.47 µM 5.02936571116561 7.67048183953229e-06 yes 10 2.4605250430011e-07 9 25236277
SGTC_2804 7954240 19.48 µM 4.82812492616754 1.66474606894468e-05 yes 11 6.89123133231619e-07 14 828705
SGTC_1164 k060-0068 93.7 µM 4.55201544068569 4.59847711306899e-05 yes 12 2.65672174410834e-06 13 5963676
SGTC_1742 st038235 28.8875 µM 4.4389500848888 6.86279623503772e-05 yes 13 4.51993883836308e-06 98 564103 YBR002C RER2
SGTC_2540 epiandrosterone 100 µM 4.41644794713795 7.42398284126562e-05 yes 14 5.01680243005658e-06 44 441302 A steroid.
SGTC_1993 st073995 70.8 µM 4.36825822455264 8.77436436827321e-05 yes 15 6.26206808226458e-06 15 3098394
SGTC_750 4073-0104 132 µM 4.35510085083753 9.18137274780448e-05 yes 16 6.65028341927964e-06 8 22330957
SGTC_1075 aripiprazole 15.2 µM 4.2612019206348 0.000126442574423972 yes 17 1.01665208803834e-05 20 60795 An atypical antipschotic. YIL048W NEO1
SGTC_1519 esterone 74 µM 4.21036197769129 0.000149972898163523 yes 18 1.27480924989077e-05 14 698 A steroid.
SGTC_68 0986-0284 82.829 µM 4.13126373606623 0.000194872823599545 yes 19 1.80387186058755e-05 63 423278 YIL048W NEO1
SGTC_275 trichlorophene 5.69 µM 4.11796526744089 0.000203556569632862 yes 20 1.91116142757451e-05 220 62616
SGTC_2526 patulin 37.61 µM 4.02839102037837 0.000272148082749281 yes 21 2.80799413460596e-05 85 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.
SGTC_341 1486-1430 230 µM 4.01598079987478 0.000283194628507982 yes 22 2.9599537730723e-05 22 2054753 YPL210C SRP72
SGTC_832 4083-0019 164 µM 3.90976461862488 0.000396325284466929 yes 23 4.61930502759733e-05 96 1990758
SGTC_3212 9128307 49.47 µM 3.8557993143604 0.000468698221344679 yes 24 5.76760466921147e-05 46 27243542
SGTC_2565 isoliquiritigenin 100 µM 3.81996135774657 0.000523330648754134 yes 25 6.67362915753874e-05 39 638278 Binds to benzodiazepine receptor 65X better than valium.
SGTC_1597 7-benzyloxygramine 47.5 µM 3.73792543732533 0.000671292351741814 yes 26 9.27724758358614e-05 137 260807
SGTC_1353 1498-1206 8.11 µM 3.70573484959574 0.000739238526444314 yes 27 0.000105389359033562 61 6756808
SGTC_2232 chlorophetanol 41.5365 µM 3.69614036979749 0.00076068353146641 yes 28 0.000109450986560122 139 15907 An antifungal of unknown mechanism. YFR051C RET2
SGTC_2040 5100729 123 µM 3.63451133628811 0.000912667618865252 yes 29 0.000139254005969011 49 11840 YJR013W | YDR381W GPI14 | YRA1
SGTC_2596 sinensetin 100 µM 3.61784439531163 0.000958316334204676 yes 30 0.00014853344947311 43 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets.
SGTC_37 0566-0070 1.56 µM 3.55221942072567 0.00115917745064526 no 31 0.000190998086114952 40 1626686
SGTC_523 1934-0222 13.7 µM 3.51149508962651 0.00130250281700408 no 32 0.000222796847346972 43 1361595
SGTC_391 gliotoxin 8.33 µM 3.50268410062559 0.00133556984278387 no 33 0.000230297681803315 78 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion
SGTC_2578 7,8-dihydroxyflavone 64.44 µM 3.48366726211768 0.00140956862883576 no 34 0.000247296982200097 50 1880 Intensifies effect of antibiotics on Staphylococcus aureus.
SGTC_116 0155-0182 31.788 µM 3.47037627911852 0.00146348922837868 no 35 0.000259864857854811 118 771486
SGTC_2801 7907800 81.82 µM 3.38501982352768 0.00185704378464046 no 36 0.000355865571327513 51 6620925
SGTC_521 r062-0005 13.8 µM 3.33100049672167 0.00215351564904021 no 37 0.000432672239948525 30 2832033
SGTC_2580 diallyl disulphide 81.36 µM 3.31379320750764 0.00225659796504914 no 38 0.000460197750987959 38 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.
SGTC_3312 9133330 71.43 µM 3.28105091735293 0.00246517395364193 no 39 0.000517105361792241 18 17617324
SGTC_3258 9138477 49.47 µM 3.25076453611697 0.00267346733856301 no 40 0.00057547568768971 19 4970355
SGTC_310 1273-0058 1.06 µM 3.22297909281582 0.00287840240253033 no 41 0.000634324065649955 320 2734232
SGTC_3099 9120367 49.47 µM 3.20021445702432 0.00305674818516999 no 42 0.000686626828855915 43 24824940
SGTC_629 3448-6466 76.7 µM 3.15702855725255 0.00342265053152423 no 43 0.000796928680970704 53 573744
SGTC_1546 5-methoxyflavanone 78.7 µM 3.15663876801643 0.00342612509003875 no 44 0.000797994632984603 34 147795
SGTC_2589 lobaric acid 100 µM 3.15233802597374 0.00346467257929934 no 45 0.000809843268285598 57 73157 A novel microtubule depolymerizer.
SGTC_1659 st012954 42.1 µM 3.15081081094801 0.0034784544392639 no 46 0.000814089588552856 34 24207262
SGTC_1623 st003709 20.3 µM 3.15027216413964 0.00348332701771135 no 47 0.000815592141800866 121 16192618
SGTC_3243 9134147 49.47 µM 3.14969079014836 0.00348859298304907 no 48 0.00081721674596005 12 24282180
SGTC_1672 st016598 6.51 µM 3.14315166367734 0.00354831742892218 no 49 0.000835696078052429 114 4665860 YNL267W PIK1
SGTC_1094 duloxetine 25.4 µM 3.13739034146222 0.00360169686406572 no 50 0.000852295120603043 56 60834 A selective serotonin reuptake inhibitor.
SGTC_2521 angolensin 13.4 µM 3.08617013084383 0.00410887656427434 no 51 0.00101376388119904 38 821428 A flavenoid.
SGTC_365 0121-0052 13.6 µM 3.08400244892119 0.00413168565867283 no 52 0.00102117957147864 118 3101739
SGTC_2165 5727197 32.143 µM 3.06042290811643 0.00438721547565232 no 53 0.00110512326611967 85 1361712
SGTC_118 0083-0097 135.343 µM 3.05160068230954 0.00448639322692321 no 54 0.00113812347662696 256 5207356
SGTC_2086 5274770 176.623 µM 3.02437966669097 0.00480514657306069 no 55 0.00124571780729307 71 689278
SGTC_2418 pentamidine 31.67 µM 3.02211553338035 0.00483254751094013 no 56 0.00125507361691499 88 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_300 r073-0011 5.04 µM 3.01125899168388 0.00496587989237419 no 57 0.00130083421084051 60 2735780
SGTC_148 3253-0744 288.01 µM 3.0051569230753 0.00504225119975331 no 58 0.00132721931214732 64 6893655
SGTC_63 0099-0242 26.702 µM 2.96520873234215 0.00556857991983306 no 59 0.00151238810946871 157 3898502 YLR359W ADE13
SGTC_1852 st056254 31.4 µM 2.95576721442877 0.00569988959888227 no 60 0.0015594619680611 48 442583
SGTC_733 4069-0007 56.1 µM 2.93131710634616 0.00605279454805363 no 61 0.00168764024132621 157 5717425 YNL287W SEC21
SGTC_3104 9120930 49.47 µM 2.92456713677395 0.00615357217954464 no 62 0.00172467832180825 51 17014836
SGTC_70 0141-0289 43.283 µM 2.92261006989601 0.0061830679899156 no 63 0.00173555455155785 296 352408
SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM 2.91992678145131 0.00622371254007405 no 64 0.00175056816680351 79 6708561
SGTC_1352 1496-0991 99 µM 2.86951238122824 0.0070325975188966 no 65 0.00205552618613501 69 3000039
SGTC_1081 sertraline 6 µM 2.86093900650645 0.00717902347128922 no 66 0.00211194152715637 74 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1
SGTC_2250 alverine citrate 130 µM 2.83504827789849 0.00763766482738081 no 67 0.00229093805150426 281 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1
SGTC_691 1548-0686 185 µM 2.82694918179406 0.00778633902914593 no 68 0.00234968924552668 112 46495133
SGTC_2900 5328528 85.29 µM 2.81474105854264 0.00801525464382329 no 69 0.00244082752638629 101 795359
SGTC_1574 spiramycin 23.7 µM 2.80542713586957 0.00819385905388408 no 70 0.00251249705688769 88 6419898 An antibiotic and protein synthesis inhibitor.
SGTC_3285 9112818 20.8695 µM 2.79930345395177 0.00831318370983075 no 71 0.00256064918654495 76 17017947 YPR165W RHO1
SGTC_3143 9086658 49.47 µM 2.79890209895603 0.00832105743641 no 72 0.00256383408258484 129 25236626
SGTC_1364 1653-0028 37.6 µM 2.79848456462159 0.00832925551609206 no 73 0.00256715116668125 78 5718652
SGTC_995 3931-2021 34.6 µM 2.756095126663 0.00919935025741636 no 74 0.00292479909183026 84 730143
SGTC_15 0266-0086 27.098 µM 2.72481844621974 0.00989138420801437 no 75 0.00321684270578086 165 1712902 YIL048W NEO1
SGTC_2546 rhodinyl acetate 100 µM 2.72323486924917 0.00992760093309256 no 76 0.00323230405010375 69 6708682
SGTC_3320 9137005 35.139 µM 2.7117500683729 0.0101937424391903 no 77 0.00334645180152297 68 4908713
SGTC_905 2-aminofluorene 215 µM 2.70866004317414 0.0102664027612308 no 78 0.00337777605891133 103 1539 An established DNA mutagen. YPR165W RHO1
SGTC_173 1273-0061 2.693 µM 2.70590138823782 0.0103316522727157 no 79 0.00340596352840417 256 2847414 YPL266W DIM1
SGTC_611 3453-1652 23.7 µM 2.69502111394342 0.0105925375620848 no 80 0.0035192085439853 95 1560575
SGTC_1478 0453-0656 35.7 µM 2.69472554351426 0.0105997040468263 no 81 0.00352233155469646 65 5258496
SGTC_2575 plumbagin 510 nM 2.68509683179438 0.0108354858903197 no 82 0.0036254397806608 122 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_1323 1348-1351 11.2 µM 2.67465830957232 0.0110962425377394 no 83 0.00374027244054355 68 6989654
SGTC_741 4582-0002 126 µM 2.67371196910949 0.011120149937781 no 84 0.00375084255912169 90 2912688
SGTC_2440 5628896 157.78 µM 2.67170588555066 0.0111709777922555 no 85 0.00377333806642624 74 5522048
SGTC_519 k048-0011 62.8 µM 2.66612030062404 0.0113135645666886 no 86 0.00383661148511231 87 6836379
SGTC_2618 avocadyne 43.43 µM 2.65154298609386 0.0116931626635859 no 87 0.00400624565061405 90 3015189
SGTC_1704 st028805 70.8 µM 2.64485904223712 0.0118708799254692 no 88 0.00408624766738365 67 2876101
SGTC_2254 7938975 95.19 µM 2.63113816340126 0.0122430547653399 no 89 0.00425497160098345 141 2969277
SGTC_2022 5136654 200 µM 2.61367431040266 0.0127313490417694 no 90 0.00447871892407393 93 1713771
SGTC_2422 chlorphenesin carbamate 384.24 µM 2.60478974624713 0.012986167866166 no 91 0.00459653271863887 146 2724 A muscle relaxant with antifungal properties.
SGTC_2603 homopterocarpin 100 µM 2.60394531839642 0.0130106148669449 no 92 0.00460787293996235 146 101795 A weak amylase inhibitor.
SGTC_1187 1391-0724 117 µM 2.59241696588593 0.0133483720439333 no 93 0.00476520921639173 89 6997986
SGTC_1328 1441-0025 69.2 µM 2.58839518775639 0.0134679705671147 no 94 0.00482121432425053 70 4562601
SGTC_2079 5212404 121 µM 2.58451794696415 0.013584145603758 no 95 0.00487576146452157 74 758462
SGTC_2135 5326629 150.42 µM 2.57664610532928 0.0138226749093041 no 96 0.00498820167331389 108 5020077
SGTC_324 1315-0088 19.6 µM 2.57023115573005 0.0140197210076757 no 97 0.00508153379526095 74 6787421
SGTC_1057 3448-5381 134 µM 2.56092512657422 0.0143098731466578 no 98 0.00521969259906719 116 5497911
SGTC_1839 st053978 48 µM 2.55106637621511 0.0146228855167087 no 99 0.00536969352021908 111 3788398
SGTC_3184 9108758 49.47 µM 2.53931951865395 0.0150035204505204 no 100 0.00555341674916698 50 902885
SGTC_2953 9074162 66.49 µM 2.52102089888827 0.0156134118490156 no 101 0.00585074510354499 103 16451992
SGTC_1571 st070080 73.4 µM 2.5122360241544 0.0159136909928917 no 102 0.00599844108053856 106 4315245
SGTC_141 0443-0274 32.331 µM 2.50280209513372 0.0162416559801664 no 103 0.00616072105769649 189 1627241
SGTC_720 r052-1644 49.9 µM 2.50225446497737 0.016260870541027 no 104 0.00617025957255609 110 1422863 YOR257W CDC31
SGTC_2503 beta-caryophyllene alcohol 24.72 µM 2.5021417675863 0.0162648271407804 no 105 0.00617222413596014 73 61125 An anti-inflammatory.
SGTC_2622 2-methoxyxanthone 59.94 µM 2.48730944172279 0.01679281017455 no 106 0.00643566941728716 108 71034 A hepatoprotective.
SGTC_34 0469-0683 81.75 µM 2.48312881671177 0.0169442495579251 no 107 0.00651169912955328 118 3690923
SGTC_677 0929-0063 136 µM 2.47701229582649 0.0171679181422964 no 108 0.00662436688211768 74 1539583
SGTC_1865 st057639 52.2 µM 2.47522589145126 0.0172337174084968 no 109 0.00665759642798236 100 688818
SGTC_2562 3',7'-dimethoxyflavone 64.92 µM 2.47029891082877 0.017416312254594 no 110 0.00675000976639442 158 688664
SGTC_2972 9093619 59.92 µM 2.4665147862479 0.0175576719841623 no 111 0.00682175476693154 122 25236256
SGTC_1231 0242-0792 125 µM 2.45496328961037 0.0179952627191052 no 112 0.00704494881261333 117 3707635
SGTC_2907 7721985 69.9 µM 2.44068154478969 0.0185491050682174 no 113 0.00732978778505784 134 3267881
SGTC_3241 9133421 49.47 µM 2.41452470288232 0.0196011284281759 no 114 0.0078778772686823 40 17018221
SGTC_774 k060-0086 136 µM 2.37623199331572 0.0212323688001012 no 115 0.00874523108483709 148 5911235
SGTC_508 roscovitine 141 µM 2.37284237666969 0.0213821415575258 no 116 0.00882589750455208 83 160355 A CDKinase inhibitor.
SGTC_264 promethazine 12.5 mM 2.36232413540117 0.0218525961722814 no 117 0.00908037788738738 224 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3
SGTC_1622 st003707 19.4 µM 2.36198199568118 0.0218680448755451 no 118 0.00908876249106266 196 10140899
SGTC_1154 4088-0362 150 µM 2.35873256133968 0.0220152275356829 no 119 0.00916873288162805 177 6618304
SGTC_681 1642-0006 26.6 µM 2.35252656047452 0.0222986518203791 no 120 0.00932317902317372 72 4446530
SGTC_908 3448-7491 47.7 µM 2.32796136405994 0.0234509183455758 no 121 0.00995707765894489 304 1203031
SGTC_3239 9133757 49.47 µM 2.31859767398766 0.0239031313540614 no 122 0.0102084306778779 58 17036923
SGTC_3210 9128157 49.47 µM 2.31850556601221 0.023907615793397 no 123 0.0102109304065533 200 17590849
SGTC_596 1155-0152 116 µM 2.31461688162935 0.0240975893860121 no 124 0.0103169540839284 199 280313
SGTC_3286 9117135 37.221 µM 2.30935140213349 0.0243568432396369 no 125 0.0104620447228482 139 3438150
SGTC_1515 3460-0031 42.1 µM 2.30370270915513 0.0246375647979915 no 126 0.0106196688327235 114 2876596
SGTC_1575 cyproterone acetate 48 µM 2.29671323330732 0.0249886718212476 no 127 0.0108175670198648 152 9880 An androgen receptor antagonist and liver toxin.
SGTC_3300 9124615 50.48 µM 2.29283151917059 0.0251854698770366 no 128 0.0109288533174836 168 24824903
SGTC_2203 7227154 166.4 µM 2.28779837755208 0.0254425762276427 no 129 0.0110746326870041 114 896304
SGTC_2692 st077426 47.7 µM 2.28380143650499 0.0256483134197055 no 130 0.011191601609626 150 25238571
SGTC_1967 st070177 51.4 µM 2.27558355697222 0.0260756952037893 no 131 0.0114354732022887 136 5729214
SGTC_2194 5927483 104.545 µM 2.26657067207536 0.0265512542384549 no 132 0.0117082326866147 151 760979
SGTC_522 1273-0010 11.6 µM 2.26523549475935 0.0266223164696192 no 133 0.0117491160315231 159 5705015
SGTC_3092 9117248 49.47 µM 2.26018926476196 0.0268923287782838 no 134 0.0119047534232467 84 17141857
SGTC_530 4358-1714 28 µM 2.25843219568451 0.0269868805652089 no 135 0.0119593636904951 198 1564641
SGTC_2352 9027995 87.8 µM 2.2573765381724 0.0270438211578231 no 136 0.011992278236175 124 2997347
SGTC_211 3455-0679 143.504 µM 2.25521587569421 0.0271606767248655 no 137 0.0120598909562649 164 748649
SGTC_1723 st034307 2.5525 µM 2.25298515610936 0.0272817629000662 no 138 0.012130042459924 174 867466
SGTC_2759 disulfiram 3.38 µM 2.24696175817867 0.0276109714925467 no 139 0.0123212356051065 175 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_2821 7996764 71.43 µM 2.24601212111803 0.0276631748231758 no 140 0.0123516157632908 219 2987135
SGTC_1857 st056007 79.3 µM 2.24375057848168 0.02778782734846 no 141 0.0124242269235191 107 619834
SGTC_3121 9125696 49.47 µM 2.24120603821131 0.0279286373993714 no 142 0.0125063659572106 80 1235365
SGTC_2720 fluspirilene 36.88 µM 2.24095292672321 0.0279426765539544 no 143 0.0125145621758817 108 3396 An atypical antipsychotic.
SGTC_3250 9135583 49.47 µM 2.23875048032745 0.0280650863589333 no 144 0.0125860779806793 117 7699353
SGTC_2553 4-methylesculetin 85.09 µM 2.23540984666307 0.0282516075582292 no 145 0.0126952271298336 166 5319502
SGTC_1375 2910-0797 186 µM 2.22466955646278 0.0288582859886655 no 146 0.013051714715264 167 742508
SGTC_2419 paclitaxel 166.5 µM 2.22252463236947 0.028980732943107 no 147 0.0131239356274749 243 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_1899 st063254 59.6 µM 2.21893893772736 0.0291863930257129 no 148 0.0132454395127978 123 3093813
SGTC_1354 1498-1681 81 µM 2.21770699423808 0.029257331251459 no 149 0.0132874085273808 176 5754243
SGTC_543 3844-1095 191 µM 2.20858899994486 0.0297868311878843 no 150 0.013601620577277 211 4230703
SGTC_1065 prochlorperazine maleate 2.48 µM 2.20761327094715 0.0298439616644148 no 151 0.0136356216199136 173 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine.
SGTC_277 nystatin 15.5 µM 2.20523696547275 0.0299834784376624 no 152 0.0137187352504984 175 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_119 0121-0043 24.815 µM 2.20148613797413 0.0302047959981453 no 153 0.0138508134838036 346 1092378
SGTC_2750 bromebric acid 70.15 µM 2.18342311838422 0.031289647821156 no 154 0.0145023324975579 205 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2
SGTC_1484 3473-2379 286 µM 2.18290115048153 0.0313214697282289 no 155 0.0145215451521227 173 671917
SGTC_952 1185-0122 232 µM 2.1812264994895 0.0314237459746763 no 156 0.0145833338643506 180 678600
SGTC_399 oxolinic acid 75 µM 2.17501626240134 0.0318054382021118 no 157 0.0148144488733676 136 4628 A DNA gyrase inhibitor.
SGTC_1840 st055363 71 µM 2.16357251986926 0.0325188213733175 no 158 0.0152485862265905 145 676033
SGTC_1153 4055-0057 267 µM 2.15296034515387 0.0331921114485793 no 159 0.0156608975957392 203 882706
SGTC_1975 st070967 30.8 µM 2.1498346654863 0.0333925955692674 no 160 0.0157841475402955 213 261391
SGTC_3280 9140961 49.47 µM 2.14890711800665 0.0334522808500879 no 161 0.0158208817316388 147 4901226
SGTC_2942 9052777 62.25 µM 2.14591071941194 0.0336456917770484 no 162 0.0159400512095216 221 6469503
SGTC_1911 st060208 74.3 µM 2.1454981495758 0.033672394188698 no 163 0.0159565196067269 201 688783
SGTC_2359 9039622 200 µM 2.13692025328597 0.0342315362653623 no 164 0.0163022391956043 188 6463596
SGTC_516 3992-2719 87.3 µM 2.13597525519538 0.0342935991090101 no 165 0.0163407154007889 170 5350887 YDR037W KRS1
SGTC_778 3456-2434 196 µM 2.13595711433492 0.0342947914159325 no 166 0.0163414547777247 269 5539063
SGTC_3165 9101544 49.47 µM 2.13531096591284 0.0343372817044669 no 167 0.0163678088915448 171 5002184
SGTC_1730 st033808 45.1 µM 2.12906960346536 0.0347499408866667 no 168 0.0166242510910383 253 1045166
SGTC_1165 k072-0275 30.3 µM 2.10833810073088 0.0361499619915991 no 169 0.0175008772522003 202 6153523 YGL055W OLE1
SGTC_661 1304-0007 33.6 µM 2.10773818977368 0.036191152330675 no 170 0.0175268209921925 176 3117130
SGTC_19 0279-0214 38.434 µM 2.1073247171348 0.0362195640373679 no 171 0.0175447211301571 291 3566274 YBR002C RER2
SGTC_2163 5671233 125 µM 2.10524184610944 0.0363629660078853 no 172 0.0176351306869341 208 701023
SGTC_993 3909-8757 62.7 µM 2.10489444203378 0.0363869293185747 no 173 0.0176502488084415 168 4288324 YLR208W SEC13
SGTC_2483 5729050 27.16 µM 2.08560774497401 0.0377377019588927 no 174 0.0185070846081761 244 2865180
SGTC_2812 7970281 58.44 µM 2.07029097372386 0.0388393571693645 no 175 0.0192125521733593 231 2233435
SGTC_1627 st003713 25.6 µM 2.04998036705539 0.040340440849009 no 176 0.0201831733559801 333 16195070 YER133W GLC7
SGTC_510 ag-490 170 µM 2.04819395593737 0.040474691974898 no 177 0.0202704992229416 131 5328779
SGTC_66 0109-0187 42.4 µM 2.04263868777472 0.040894497031038 no 178 0.0205441091780777 214 759417
SGTC_1944 st076371 56.9 µM 2.03907346515382 0.0411657726927323 no 179 0.0207213480103328 219 24208455
SGTC_3057 9095946 49.47 µM 2.03206183833318 0.0417035391562306 no 180 0.0210736980450381 156 24540043
SGTC_235 0330-0087 5 mM 2.03000801900246 0.0418621326983242 no 181 0.0211778620889985 222 46494818 YHR062C RPP1
SGTC_3067 9117431 49.47 µM 2.02726837875177 0.042074444338526 no 182 0.0213174867550315 169 17150885
SGTC_2296 7971656 126.45 µM 2.02024551435253 0.0426226717658513 no 183 0.0216789636722619 248 666570
SGTC_2499 avocadenofuran 51.48 µM 2.01578456462368 0.0429738974476926 no 184 0.0219112541460143 238 6857792 A insecticide and lysyl oxidase inhibitor.
SGTC_3267 9137951 49.47 µM 2.00865666239979 0.0435399514018884 no 185 0.0222867788559984 131 16643986
SGTC_1412 3909-8563 178 µM 1.99890066943424 0.0443244509647507 no 186 0.0228095511533924 239 23767530
SGTC_2940 9060638 45.86 µM 1.99484435282084 0.0446539628285598 no 187 0.0230299291426003 236 4027022
SGTC_2723 salbutamol 83.58 µM 1.98971043997486 0.045073838097893 no 188 0.0233114209942279 109 9884233 β2-adrenoceptor agonist
SGTC_2222 6885208 172.143 µM 1.98793775131723 0.0452195526302781 no 189 0.0234092874546523 128 609514
SGTC_3223 9129970 49.47 µM 1.98609919100322 0.0453710819360332 no 190 0.0235111555492297 229 17248386
SGTC_361 000s-0510 1.45 µM 1.98568411947119 0.0454053474868327 no 191 0.0235342047138448 250 660
SGTC_2023 5144124 124 µM 1.98403522885388 0.0455416745717115 no 192 0.0236259563963203 217 2830192
SGTC_3102 9121669 49.47 µM 1.97842136667074 0.0460082872173727 no 193 0.0239405956424024 158 41905072
SGTC_407 eburnamonine 100 µM 1.97411311862314 0.0463689783675675 no 194 0.0241844409945642 198 3195
SGTC_2514 salinomycin 42.74 µM 1.97383647919128 0.046392216265081 no 195 0.0242001697122092 298 23682228 A polyether potassium ionophore.
SGTC_3338 9144300 39.5675 µM 1.97362198555533 0.0464102403079577 no 196 0.024212370957258 236 4901274
SGTC_1646 st011709 75.6 µM 1.97051857529831 0.0466716515108447 no 197 0.0243894841259549 179 5757843
SGTC_2660 2',4'-dihydroxychalcone 17.14 µM 1.97032337924214 0.0466881329753083 no 198 0.0244006603260667 203 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_1914 st062367 72.6 µM 1.96359251578547 0.0472593188164478 no 199 0.024788683014333 214 978205
SGTC_46 0329-0187a 2.197 µM 1.96262592405591 0.0473418024426524 no 200 0.0248448280843096 330 46494817
SGTC_195 4234-0266 16.654 µM 1.9600138390207 0.0475652806437529 no 201 0.0249970863937506 279 2303354
SGTC_2987 9018338 71.43 µM 1.95919942005037 0.0476351312052094 no 202 0.025044718518018 253 5055682
SGTC_719 2810-4230 27.3 µM 1.95141365749324 0.0483070500658237 no 203 0.0255039290585316 154 721079
SGTC_1957 st077035 62.4 µM 1.95108097586185 0.0483359288530214 no 204 0.0255237069437449 196 705593
SGTC_3017 9080681 49.47 µM 1.95071382934 0.0483678154297427 no 205 0.02554554866927 215 16451914
SGTC_1147 3809-1045 12.3 µM 1.94463828370314 0.0488979216742924 no 206 0.0259092641201203 247 325925
SGTC_714 4296-0578 26.1 µM 1.94156064855468 0.0491682188447307 no 207 0.0260951553220482 116 1589775
SGTC_33 0986-0033 35.816 µM 1.93776682699243 0.0495030566537256 no 208 0.0263258383358182 188 2848082
SGTC_2081 5214970 32.255 µM 1.93261128739707 0.0499609922505534 no 209 0.0266420504476515 223 2063512
SGTC_2611 pyromycin 23.93 µM 1.93138110930299 0.0500707592840392 no 210 0.0267179697688839 266 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release.
SGTC_1501 4491-0275 38.4 µM 1.92932007248415 0.0502550935132375 no 211 0.026845569682348 207 5104718
SGTC_964 1287-0107 19.4 µM 1.9220351775447 0.0509109753630181 no 212 0.0273006657774203 272 51516812 YPR165W RHO1
SGTC_3028 9087778 49.47 µM 1.91990121667109 0.0511043875935283 no 213 0.0274351891108844 213 17217395
SGTC_2805 7950783 58.44 µM 1.91578437598227 0.051479170647689 no 214 0.0276962736311682 279 1178958 YDL195W SEC31
SGTC_2478 5763493 32.33 µM 1.91392877673661 0.0516488111341053 no 215 0.027814628439325 225 1365576 YLR208W SEC13
SGTC_3066 9117245 49.47 µM 1.90391611172149 0.0525718597355337 no 216 0.0284605552068183 235 17176980
SGTC_936 3005-4620 401 µM 1.90235595747145 0.0527168591816524 no 217 0.0285623173665562 280 777207
SGTC_1838 st055369 84.5 µM 1.89908827483298 0.0530215831546864 no 218 0.0287764352428592 222 676036
SGTC_2802 7925815 54.55 µM 1.89903935631201 0.0530261555845942 no 219 0.0287796507846267 295 1262923
SGTC_1882 5615643 20 µM 1.89586146377797 0.0533238647879401 no 220 0.0289891829083132 214 2253075
SGTC_1052 3253-3998 198 µM 1.89223836540164 0.0536648959505217 no 221 0.0292296143988464 299 5450317
SGTC_1943 st076331 65.2 µM 1.88729694533025 0.0541327989304544 no 222 0.0295601985418156 233 24208415
SGTC_852 0418-0143 439 µM 1.88458964013388 0.054390519317608 no 223 0.029742631038347 333 5369229
SGTC_2762 leflunomide 42.06 µM 1.88328282736424 0.0545152674657533 no 224 0.0298310246970677 279 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1
SGTC_1313 1220-0047 237 µM 1.88049498965871 0.0547821502539546 no 225 0.0300203242915902 317 3528706
SGTC_1185 1319-0113 81.3 µM 1.88047216394137 0.0547843396401732 no 226 0.0300218783037542 226 4672763
SGTC_633 0437-0093 97.7 µM 1.87977300594212 0.0548514346542589 no 227 0.0300695104466387 219 2831118
SGTC_204 PMA1.184 62.41 µM 1.87735051201896 0.0550844128739286 no 228 0.0302350347081482 278 2252213 YGL008C PMA1
SGTC_363 0455-0021 3.06 µM 1.87503056072882 0.0553082614680667 no 229 0.0303942596667666 314 4597466
SGTC_974 1326-0144 138 µM 1.87022963259369 0.0557737769659952 no 230 0.0307259682010103 297 5411856
SGTC_1647 st011722 22.4 µM 1.86879941896738 0.0559130517773529 no 231 0.030825362871908 235 2854783
SGTC_3051 9093778 49.47 µM 1.86599485892221 0.0561869574108453 no 232 0.0310210423889163 168 17217378
SGTC_1411 3909-8223 150 µM 1.84947667459542 0.0578217206796039 no 233 0.032194506435444 255 X1411
SGTC_5 0352-0601 109.883 µM 1.84787106586068 0.0579825974617971 no 234 0.0323104985748292 193 762456
SGTC_1468 k284-1086 134 µM 1.84474704544713 0.0582966221095015 no 235 0.0325371719096092 336 15996457
SGTC_1782 st039423 80.636 µM 1.84473246119955 0.0582980912358664 no 236 0.0325382331847004 268 2068169
SGTC_2132 5317594 122.667 µM 1.84285310275801 0.0584876495647027 no 237 0.0326752305441534 218 794577
SGTC_3330 9141424 71.43 µM 1.83745690800254 0.0590346182105299 no 238 0.0330712361824305 295 27261020
SGTC_851 0394-0702 453 µM 1.83132561508524 0.0596609588121096 no 239 0.0335259782819747 272 762646
SGTC_1614 st002383 48.6 µM 1.8298738272161 0.0598100255885084 no 240 0.0336344039762314 264 1947235
SGTC_667 1498-1044 59 µM 1.82780496103659 0.0600229567356101 no 241 0.033789414206585 272 6739982
SGTC_1881 5652484 16 µM 1.82775489437817 0.0600281170264236 no 242 0.0337931727331925 289 2255129
SGTC_1695 st026914 34.495 µM 1.82755145626866 0.0600490886424656 no 243 0.0338084484622795 276 3289191
SGTC_2885 9057732 51.95 µM 1.82402216988991 0.0604138223878222 no 244 0.0340743603234668 272 6471414
SGTC_1278 0874-0585 172 µM 1.82366632248849 0.0604506934037254 no 245 0.0341012665990686 260 766306
SGTC_1483 3453-0561 55.9 µM 1.82353203382959 0.0604646122559663 no 246 0.0341114249502249 302 4546991
SGTC_2454 5-benzylidenerhodanine 10.36 µM 1.82351268607749 0.0604666178330307 no 247 0.0341128887282916 304 1273210
SGTC_2460 5552655 174.22 µM 1.80823831562679 0.0620662563495411 no 248 0.0352847088179149 293 5401989
SGTC_1467 k284-1082 293 µM 1.80777336208441 0.0621154624249857 no 249 0.0353208906248741 274 3334705
SGTC_569 4130-2812 160 µM 1.79574402950427 0.063399136849867 no 250 0.0362676179719797 195 743552
SGTC_800 3448-7362 155 µM 1.78919614272471 0.0641065028810366 no 251 0.0367916163363041 584 15991913
SGTC_1103 duloxetine 36.1 µM 1.78887960945611 0.064140852710997 no 252 0.0368171031590886 342 60835 A selective serotonin reuptake inhibitor.
SGTC_2064 5220758 200 µM 1.78336091458329 0.0647420372265126 no 253 0.0372637856925044 346 788518
SGTC_494 Boc-Gly-Val-Val-CHO 140 µM 1.78064783975088 0.0650391886278376 no 254 0.0374849996195707 243 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA.
SGTC_2790 5423970 71.43 µM 1.77289412559744 0.0658942562783083 no 255 0.0381231261329787 367 1376240 YKL165C | YIL048W MCD4 | NEO1
SGTC_652 0437-0092 114 µM 1.77124112130216 0.0660776686675019 no 256 0.0382603069071755 256 3091274
SGTC_317 4495-0002 170 µM 1.76476571636109 0.0667999715285454 no 257 0.0388015743794565 262 15991618
SGTC_625 k213-0058 121 µM 1.76459619506467 0.0668189626141342 no 258 0.0388158277098775 482 3655420
SGTC_382 3229-0966 23.2 µM 1.75166773863923 0.0682796526135779 no 259 0.0399154786796111 306 5722370
SGTC_889 0919-1524 82.7 µM 1.74967006232444 0.0685075366573926 no 260 0.0400876312209544 295 3905452
SGTC_1391 3442-0225 151 µM 1.74771788004385 0.0687307973721305 no 261 0.0402564455785203 251 5227075
SGTC_3141 9094609 49.47 µM 1.74671110221301 0.0688461562747055 no 262 0.0403437317945218 317 25236309 YDL196W YDL196W
SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM 1.74565670675213 0.0689671312842057 no 263 0.0404353110984395 349 5024745
SGTC_144 4161-2749 112.381 µM 1.74557599532105 0.0689763983765822 no 264 0.0404423282225215 256 797501 YMR168C CEP3
SGTC_2564 betulinic acid 100 µM 1.73985396814989 0.0696358369210289 no 265 0.0409423316304047 349 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14
SGTC_898 1000-0849 28.3 µM 1.73976944167345 0.0696456144792973 no 266 0.0409497551545688 259 6751807
SGTC_3107 9121808 49.47 µM 1.73898749134363 0.0697361163177442 no 267 0.0410184815965128 206 662681
SGTC_2267 7931562 200 µM 1.73825058194634 0.0698214880104379 no 268 0.0410833349347306 289 934880
SGTC_1833 st055984 71 µM 1.73767914340763 0.0698877450926189 no 269 0.0411336828642206 286 676288
SGTC_509 pifithrin 175 µM 1.73699906016628 0.0699666623430132 no 270 0.0411936683802049 251 4817 A p53 inhibitor.
SGTC_2674 ligustilide 100 µM 1.73328513033648 0.0703988390754578 no 271 0.0415225011836392 248 5319022 A signalling regulator.
SGTC_499 genistein 192 µM 1.73051496681641 0.0707225273042019 no 272 0.04176915476484 204 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger.
SGTC_1247 0448-0043 5.84 µM 1.72900151367368 0.070899853803743 no 273 0.0419044120851436 377 3089013 YGL099W LSG1
SGTC_582 0987-0078 156 µM 1.72746410868983 0.0710803361652443 no 274 0.0420421728422214 453 1625765
SGTC_831 k061-1017 217 µM 1.72702751431188 0.0711316540638467 no 275 0.0420813610940261 476 1240153
SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM 1.72534359474629 0.0713298507704956 no 276 0.0422327849421795 329 688761
SGTC_127 0180-0333 59.125 µM 1.72325274562473 0.0715765325496737 no 277 0.042421414537138 411 771601
SGTC_2429 5902844 64.44 µM 1.72165215197018 0.0717658151277804 no 278 0.0425662749097621 354 1927790 YGL093W | YPR107C SPC105 | YTH1
SGTC_3154 9100113 49.47 µM 1.7186613915063 0.0721205243074947 no 279 0.0428380230023535 315 25237525
SGTC_1116 jasmonic acid 1.58368 µM 1.71842835245785 0.072148219465334 no 280 0.0428592562717364 311 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid.
SGTC_2152 5568786 200 µM 1.71683458780735 0.0723378464782566 no 281 0.0430046996620578 304 5399883
SGTC_2391 6285546 200 µM 1.7154297709748 0.0725053088352895 no 282 0.0431332305184589 350 846083
SGTC_1799 st045822 46.1415 µM 1.71358194275388 0.0727260327470582 no 283 0.0433027661075558 283 3674992
SGTC_2956 9076196 2.52 µM 1.70826711843331 0.0733637593144095 no 284 0.0437933947914824 327 16423868
SGTC_133 0724-0033 378.92 µM 1.70294371446883 0.0740067942613829 no 285 0.0442893011042601 300 280309
SGTC_614 0462-0418 107 µM 1.70191739620358 0.0741312609416784 no 286 0.0443854271041666 305 5188303
SGTC_2332 7982454 138.89 µM 1.6984487370005 0.0745531059495478 no 287 0.044711550096097 384 2981748
SGTC_1530 rhein 70.4 µM 1.6948505337725 0.0749926392892135 no 288 0.0450518891656707 344 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death.
SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM 1.68781394402581 0.0758578917691469 no 289 0.0457234750150497 228 4620898
SGTC_703 3875-0075 71.8 µM 1.68535540749828 0.0761619906873161 no 290 0.0459600108081431 284 2850814
SGTC_104 0074-0074 590.992 µM 1.68370762289407 0.0763663256470089 no 291 0.0461190937101236 197 3943124
SGTC_555 4296-0685 37 µM 1.6824085091207 0.0765277172375178 no 292 0.0462448262519667 337 2908540 YHR072W ERG7
SGTC_3046 9092212 49.47 µM 1.6810324975296 0.0766989448092207 no 293 0.0463783012430523 288 25236637
SGTC_1624 st003710 6.25 µM 1.67928350711408 0.0769170052726987 no 294 0.0465484018789516 394 24207033
SGTC_3115 9123671 49.47 µM 1.67505403761185 0.077446274138384 no 295 0.0469618148914529 282 3286988
SGTC_3055 9094636 49.47 µM 1.67482921386326 0.0774744854412061 no 296 0.0469838726301445 299 25236176
SGTC_2529 gangaleoidin 93.61 µM 1.6743356822591 0.0775364420751545 no 297 0.0470323227685557 288 4565183
SGTC_2943 9068529 45.32 µM 1.6715902105505 0.0778817882057527 no 298 0.0473025782404219 380 3270634
SGTC_1371 2421-0008 32.7 µM 1.66773629432672 0.0783685305248848 no 299 0.0476840435809855 371 2827552
SGTC_1336 1486-0901 104 µM 1.66532630513036 0.0786740776679926 no 300 0.0479238366056568 329 5006114
SGTC_2489 cantharidin 73.42 µM 1.66479455892568 0.0787416157869303 no 301 0.0479768749262924 400 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_2304 7443016 91.4 µM 1.66426620760622 0.0788087662191733 no 302 0.0480296211525253 288 939854
SGTC_921 1561-0023 372 µM 1.66005860227407 0.0793450782291313 no 303 0.0484513319634988 354 24050882
SGTC_1915 st067105 30.6 µM 1.65762791035941 0.0796561568129979 no 304 0.0486962963056898 373 69751 YOR207C | YOR116C RET1 | RPO31
SGTC_3274 9138298 49.47 µM 1.65472910673603 0.0800283493770065 no 305 0.0489897300405421 369 17015756
SGTC_1853 st056710 91.2 µM 1.648094271194 0.0808851773873465 no 306 0.0496666638593431 344 269167
SGTC_1947 st076332 61.6 µM 1.64724442511355 0.0809954256685664 no 307 0.0497539079324918 279 24208416
SGTC_1690 st023502 41.2 µM 1.6465388009259 0.0810870505778422 no 308 0.0498264392397899 311 24207482
SGTC_554 4483-2211 187 µM 1.64344032605534 0.0814903118585539 no 309 0.050145931199862 355 747107
SGTC_1087 pterostilbene 9.05 µM 1.6426253401584 0.0815966317025075 no 310 0.0502302372707096 378 5281727 Similar to reservatol, lowers cholesterol.
SGTC_2817 7995342 71.43 µM 1.64108369958805 0.0817980340433255 no 311 0.0503900209564358 303 18879975
SGTC_1696 st025591 34.7925 µM 1.63943674294596 0.0820136087607517 no 312 0.050561167345309 377 2787147
SGTC_1148 3909-7663 27.7 µM 1.63400236734424 0.082727966035748 no 313 0.0511291767577698 350 4084526
SGTC_2090 5301565 104.445 µM 1.62515033888065 0.0839015895200748 no 314 0.052065264527606 400 2056344
SGTC_2302 7771753 200 µM 1.62436495241334 0.0840063188323879 no 315 0.0521489712020757 412 2203047
SGTC_3304 9125678 46.087 µM 1.6191476718223 0.0847045231796345 no 316 0.0527077468980557 400 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2
SGTC_2438 5259590 200 µM 1.61737591348903 0.0849426165362267 no 317 0.0528985808722226 359 1201127
SGTC_1255 0566-0045 221 µM 1.61728157292866 0.084955308312452 no 318 0.0529087575290708 380 2788469
SGTC_1090 efavirenz 20.7 µM 1.61160395071244 0.08572174699659 no 319 0.0535240752224405 343 64139 A non-nucleoside reverse transcriptase inhibitor.
SGTC_601 0986-0029 62.9 µM 1.61134494859702 0.0857568334949839 no 320 0.0535522794745225 407 24747981
SGTC_2367 9070478 135.38 µM 1.60244123287447 0.0869695487348529 no 321 0.0545290365284177 398 572802
SGTC_1904 st060225 78 µM 1.59449893976875 0.0880620850050105 no 322 0.0554121640091508 351 66595
SGTC_1462 k081-0014 26.5 µM 1.59037793588155 0.0886329840964311 no 323 0.055874820352295 245 3270634
SGTC_325 2810-4341 181 µM 1.5886364895503 0.0888750604857406 no 324 0.0560712425361252 338 774970
SGTC_2964 9083345 53.42 µM 1.58830287863872 0.0889214914735767 no 325 0.0561089334435784 347 17741579
SGTC_401 neomycin 50 µM 1.58817130471788 0.0889398085105256 no 326 0.0561238039790127 324 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis.
SGTC_105 0111-0055 734.78 µM 1.5861915891077 0.0892157534034334 no 327 0.0563479275877362 300 5179370
SGTC_2849 9019321 12.99 µM 1.58455645281917 0.0894441486842038 no 328 0.0565335728534166 358 16489627
SGTC_3187 9109394 49.47 µM 1.57861783530226 0.0902773110627088 no 329 0.0572118706163857 397 17098090
SGTC_2139 5578692 56.4705 µM 1.57548537670265 0.0907190968694584 no 330 0.0575722256179683 321 650991 YMR113W FOL3
SGTC_2682 pyrogallin 40.03 µM 1.57352978999969 0.0909957150516048 no 331 0.0577980980022976 422 822798 An ATP competetive kinase inhibitor.
SGTC_2171 5739187 198.077 µM 1.5732218320622 0.0910393327323908 no 332 0.0578337308876863 320 2262761
SGTC_413 propylparaben 100 µM 1.57136963840897 0.091301995696685 no 333 0.0580484070587972 342 7175 A pharmaceutical preservative.
SGTC_2368 9071271 200 µM 1.56781078786802 0.0918082589678923 no 334 0.0584626482578336 385 27209959
SGTC_2925 9010536 32.5 µM 1.56746008560704 0.0918582603490015 no 335 0.0585035944429814 470 2994177
SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM 1.56650472288503 0.091994573516173 no 336 0.0586152518900894 371 6708514
SGTC_3355 9151058 44.0485 µM 1.56158187499021 0.0926993510050906 no 337 0.0591932610343739 375 17015728
SGTC_2195 6536160 144.242 µM 1.55894321745624 0.093078753289757 no 338 0.0595049101212535 344 3834386
SGTC_1208 2323-2347 50.3 µM 1.55604900019991 0.0934962199785886 no 339 0.0598482204805308 358 5412760
SGTC_909 3448-9333 149 µM 1.55571500345198 0.0935444850825526 no 340 0.0598879386331416 362 3344074
SGTC_3079 9117512 49.47 µM 1.55558155151156 0.0935637750603266 no 341 0.0599038142135037 322 7185044
SGTC_1459 k035-0031 35.7 µM 1.55421762255597 0.093761094336406 no 342 0.0600662576674529 328 3877128 YMR208W ERG12
SGTC_1796 st049173 110.4 µM 1.55190175872063 0.0940968331530334 no 343 0.0603428660224726 309 94134
SGTC_308 4092-1169 104 µM 1.55003399950137 0.0943682541868064 no 344 0.0605666778633873 427 2268590 YDL196W YDL196W
SGTC_58 0957-0393 9 µM 1.54936497169193 0.0944656169958125 no 345 0.0606470046279888 749 6997992
SGTC_3273 9137859 49.47 µM 1.54724032981252 0.0947753046313307 no 346 0.0609026521734368 331 2377234
SGTC_2091 4-phenylthiadiazole 200 µM 1.54518142525554 0.0950761235766446 no 347 0.0611511929754887 412 270010
SGTC_2696 st077691 74.316 µM 1.54504449246843 0.0950961552334548 no 348 0.0611677508971994 370 757133
SGTC_1692 fluoroquinolonic acid 71 µM 1.54371000294073 0.0952915381439804 no 349 0.0613293009710503 347 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2
SGTC_433 pimozide 108 µM 1.54229192510777 0.095499482972597 no 350 0.0615013351530885 302 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic
SGTC_1268 0828-0275 2.46 µM 1.54194587366776 0.0955502780985622 no 351 0.0615433735561148 392 745337
SGTC_1228 0124-0032 52.5 µM 1.54095503159121 0.0956958287179301 no 352 0.0616638653847044 417 X1228
SGTC_2256 7954252 200 µM 1.53905689794891 0.0959751121808241 no 353 0.0618952031605974 300 2972920
SGTC_2134 5324836 1.464 µM 1.53745132681681 0.0962118167697722 no 354 0.0620914127799485 325 699272
SGTC_2598 perillyl alcohol 100 µM 1.52948220311535 0.0973930340279471 no 355 0.0630724738392711 417 10819 An apoptosis inducer.
SGTC_901 1112-0062 60.1 µM 1.52871236052432 0.0975077043949269 no 356 0.0631678833548915 382 1908457
SGTC_397 arbidol 50 µM 1.52625544439551 0.0978743316897787 no 357 0.0634731301159998 418 131410 A RNA synthesis inhibitor.
SGTC_2059 5238311 157 µM 1.52458897234405 0.0981235813372674 no 358 0.0636808248320472 390 703021
SGTC_355 1311-2252 105 µM 1.52326511887425 0.0983219176732988 no 359 0.0638461950658052 424 5338538
SGTC_1578 josamycin 24.2 µM 1.51410536863213 0.0997022566120787 no 360 0.0649995586292843 369 5282165 A P450 substrate.
SGTC_3124 9127567 49.47 µM 1.51307762713914 0.099858012331424 no 361 0.0651299709150183 378 17592030
SGTC_3026 9090633 49.47 µM 1.51189073778922 0.10003810819239 no 362 0.0652808303506291 415 25236842
SGTC_2317 5986382 200 µM 1.50966442585321 0.100376563101678 no 363 0.0655645364769017 389 877883
SGTC_2668 2',4'-dihydroxychalcone 15.08 µM 1.50701649384322 0.100780201835075 no 364 0.0659032147495934 374 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_1548 st061468 90.8 µM 1.50687353821349 0.100802026969855 no 365 0.0659215376951088 401 390799
SGTC_3301 9125354 19.7965 µM 1.50628223210902 0.100892338693613 no 366 0.0659973686700725 369 41905162
SGTC_2404 5161160 200 µM 1.50542682892627 0.101023091031881 no 367 0.0661071878822937 452 2831543
SGTC_271 rotenone 740 µM 1.49921907432583 0.101975677309259 no 368 0.0669084041366529 457 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria.
SGTC_2408 sulbentine 18.36 µM 1.4943068150804 0.102734088548031 no 369 0.0675477223417134 438 67686 An antifungal agent of unknown mechanism. YDL205C HEM3
SGTC_441 propafenone 146 µM 1.49257401781274 0.103002593395474 no 370 0.067774364364682 362 4932 Slows the influx of sodium ions into the cardiac muscle.
SGTC_40 0327-0103 19.753 µM 1.49173785412123 0.103132342968837 no 371 0.0678839406779205 422 409036
SGTC_2453 5731132 22.18 µM 1.48861494678687 0.103617981638286 no 372 0.068294396701984 446 1362040
SGTC_1596 piperlongumine 63 µM 1.48585126412395 0.104049139994966 no 373 0.0686592334781483 450 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_2694 st077685 81.9 µM 1.47782927483742 0.105308004224682 no 374 0.0697267402534387 436 2838096
SGTC_2191 5911152 200 µM 1.47720657305398 0.105406181644265 no 375 0.0698101361915126 418 2875902
SGTC_1986 st071812 45 µM 1.47647599615347 0.105521451430848 no 376 0.0699080772545154 381 11838594
SGTC_2087 5276107 200 µM 1.47458615048831 0.105820052489894 no 377 0.0701619202921377 408 144405
SGTC_2512 diallyl trisulfide 49.23 µM 1.4727071889752 0.106117538843426 no 378 0.0704150036474483 367 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent
SGTC_2569 tetrandrine 100 µM 1.4675452542545 0.106937910300822 no 379 0.0711138940487688 393 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_1651 st011928 86.1 µM 1.46656299081958 0.107094535363157 no 380 0.0712474869533055 432 720198
SGTC_2652 actinonin 100 µM 1.4586007946836 0.108370241863602 no 381 0.0723375073816232 391 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase.
SGTC_1439 4092-1168 46 µM 1.45761715616705 0.108528596563737 no 382 0.0724730490472451 429 2886240
SGTC_170 4197-0004 226 µM 1.45381071984722 0.109142958199441 no 383 0.0729993953092969 387 218692
SGTC_1419 3993-2473 62.6 µM 1.45241987793651 0.109368063356342 no 384 0.0731924462420516 446 704026
SGTC_2034 5197015 53.07 µM 1.45137987452437 0.109536603743925 no 385 0.0733370553311337 456 780676
SGTC_1463 k081-0032 34.1 µM 1.45010006382083 0.109744262583868 no 386 0.0735153086665666 353 977755
SGTC_1056 3448-1962 115 µM 1.44395000838296 0.110746097065139 no 387 0.074376519063651 424 715507
SGTC_2872 9044037 25.97 µM 1.44264674583993 0.1109592353787 no 388 0.0745600039844766 362 6465195
SGTC_752 1896-0090 130 µM 1.43944066284344 0.111484815064137 no 389 0.0750128552184324 450 772567
SGTC_3325 9138760 55.175 µM 1.43731345696681 0.111834513961063 no 390 0.0753144734209952 456 43844959
SGTC_1289 0976-0073 69.1 µM 1.43723507797995 0.111847413928394 no 391 0.0753256044729246 467 3391136
SGTC_1879 gemcitabine 100 µM 1.43507668652131 0.112203069970757 no 392 0.0756326230760247 448 60750 A nucleoside analog which inhibits DNA replication.
SGTC_1117 retinoic acid 1.10837 µM 1.4279246855482 0.11338733907173 no 393 0.0766567687434069 500 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR).
SGTC_1348 1493-0373 93.8 µM 1.42592393228871 0.113720225298868 no 394 0.0769451502174418 449 3010129
SGTC_336 4111-0029 111 µM 1.4255957392687 0.113774896639707 no 395 0.0769925334218113 383 3131175
SGTC_954 1189-0853 2.85 µM 1.42164902358618 0.114433819476022 no 396 0.0775640827710886 472 2828194
SGTC_2789 5281112 71.43 µM 1.41731567615658 0.115160416144527 no 397 0.0781953269700882 475 765948
SGTC_2085 5307070 144.047 µM 1.41686600140701 0.115236003060828 no 398 0.0782610541669632 418 2840351
SGTC_1873 rapamycin 2 nM 1.411945311812 0.116065438880141 no 399 0.0789830322313901 530 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1
SGTC_2000 st075254 36.4 µM 1.41043860156568 0.11632025668793 no 400 0.0792051069953025 418 17234175
SGTC_282 k297-0036 65.7 µM 1.40929082938065 0.116514636357218 no 401 0.0793745946982374 418 5061378
SGTC_1848 st056003 16.4 µM 1.40910317736608 0.116546437852642 no 402 0.0794023307377345 489 146492
SGTC_2122 5258151 111.688 µM 1.40697839315253 0.116906955793136 no 403 0.0797168979468508 471 2173356
SGTC_2433 5607874 27.82 µM 1.40590575925372 0.117089252439477 no 404 0.0798760554578709 482 2252428
SGTC_1394 3474-0001 65.7 µM 1.40135146421224 0.117865508361252 no 405 0.0805544992926004 429 5017666 YIL048W NEO1
SGTC_2824 7998404 51.95 µM 1.39989252404195 0.118114945465721 no 406 0.080772752547277 442 837851
SGTC_3348 9149464 3.537 µM 1.39903489117665 0.118261750312502 no 407 0.080901260176467 475 1951442
SGTC_1461 k072-0203 53.8 µM 1.39894010149936 0.118277983798729 no 408 0.080915472919711 456 5418714
SGTC_880 0833-0487 87.2 µM 1.39593338793482 0.118793725188234 no 409 0.0813672776257565 477 76075
SGTC_1137 ixabepilone 100 µM 1.39542251146608 0.118881513442912 no 410 0.0814442333944526 547 154225 A novel microtubule stabilizer.
SGTC_2922 7999257 32.47 µM 1.390192556223 0.119782857280251 no 411 0.0822352066245839 421 2988377
SGTC_520 3584-0023 682 µM 1.39000118799278 0.11981592930909 no 412 0.0822642583039228 477 1340790
SGTC_1299 1079-1439 3.74 µM 1.38957592132077 0.119889446436566 no 413 0.082328845862218 474 323161
SGTC_1584 6-fluoro-dl-tryptophan 90 µM 1.38954894651236 0.119894110725077 no 414 0.0823329439603528 499 94937 An inhibitor of serotonin biosynthesis.
SGTC_2783 7738165 71.43 µM 1.38867976537057 0.120044471710326 no 415 0.0824650749400728 391 17201110
SGTC_2712 st079126 47.7 µM 1.38111880691692 0.121358061503857 no 416 0.0836212169384733 456 3152970
SGTC_834 0312-0008 75.7 µM 1.37877252558926 0.121767735719482 no 417 0.083982450087968 528 6385573 YIL048W NEO1
SGTC_1854 st056233 32.9 µM 1.3775657925004 0.12197881623311 no 418 0.0841686942415401 475 5393174
SGTC_3085 9117376 49.47 µM 1.37698972912906 0.122079671217367 no 419 0.0842577116666485 484 16480349
SGTC_2217 6934799 96.0675 µM 1.37509328507356 0.122412107080569 no 420 0.0845512629481227 473 675606
SGTC_206 4546-0025 72.014 µM 1.3750482034934 0.12242001734846 no 421 0.0845582504662434 572 6620745 YIL048W NEO1
SGTC_647 0140-0236 81 µM 1.37367989421474 0.122660279295153 no 422 0.0847705407116135 553 990837
SGTC_850 0388-0143 75.9 µM 1.37281184638149 0.122812871519755 no 423 0.0849054235051138 469 67273
SGTC_3122 9126309 49.47 µM 1.37110766457678 0.123112833013921 no 424 0.085170698016762 460 17591206
SGTC_93 0109-0045 59.227 µM 1.37058291086387 0.123205300837415 no 425 0.085252506595258 607 88733
SGTC_2042 p-Dimethylaminoacetophenone 200 µM 1.37026453674503 0.123261425847128 no 426 0.0853021694887661 481 75037 A free radical scavenger.
SGTC_2911 7942208 15.64 µM 1.36940828918273 0.123412459475829 no 427 0.0854358423040282 437 1243384
SGTC_2468 5987765 72.9 µM 1.36422085505677 0.124330243588513 no 428 0.0862490331856993 500 26772094
SGTC_2749 bexarotene 57.39 µM 1.36410111888582 0.124351484061323 no 429 0.0862678713459863 507 82146 An retinoic acid receptor inhibitor.
SGTC_1195 1502-0147 41.1 µM 1.36310796936056 0.124527760604534 no 430 0.086424242763316 538 817940
SGTC_2097 5376186 200 µM 1.36149125364333 0.124815088964931 no 431 0.086679247846652 513 742755
SGTC_3193 9111931 49.47 µM 1.35526230866653 0.125926448177051 no 432 0.0876669995415425 513 17087244
SGTC_1901 st060216 58.6 µM 1.3543260147445 0.126094095106098 no 433 0.0878161950127486 516 688792
SGTC_574 1315-0397 40 µM 1.35286969531953 0.126355163655637 no 434 0.0880486311604452 590 6794277
SGTC_1155 4088-0394 48.2 µM 1.34569494480966 0.127646850065637 no 435 0.0892004586772535 522 2326248
SGTC_1931 st074438 57.1 µM 1.34549495099023 0.127682986427766 no 436 0.0892327253550152 479 2787313
SGTC_181 1447-1644 8.07 µM 1.34490336461528 0.127789920254889 no 437 0.0893282217780116 507 534600
SGTC_1366 1683-0113 21.9 µM 1.34340696422075 0.12806068401916 no 438 0.089570116537925 494 708623
SGTC_531 3788-1495 174 µM 1.34246960734778 0.128230495418033 no 439 0.0897218892298749 504 2896655
SGTC_476 mead acid 10 µM 1.33878731049688 0.128899093024316 no 440 0.0903199614795665 448 5312531 An omega 9 fatty acid.
SGTC_447 ml7 120 µM 1.33845578802814 0.128959406252267 no 441 0.0903739517163917 515 4216 Selective myosin light chain kinase inhibitor.
SGTC_2495 cafestol 54.53 µM 1.33712621901161 0.129201488746456 no 442 0.0905907200641297 483 16667697 An anti-infammatory.
SGTC_2912 7964298 10.93 µM 1.33606143364691 0.129395587542272 no 443 0.0907645971241695 598 2975850
SGTC_2787 5284540 71.43 µM 1.3357183213728 0.129458176204346 no 444 0.0908206793151952 512 736958
SGTC_3013 9080133 71.4286 µM 1.33346730781711 0.129869313995538 no 445 0.0911892485232905 572 17050193
SGTC_224 benfluorex 43.875 µM 1.33330090027162 0.129899743451904 no 446 0.0912165391897574 401 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis.
SGTC_289 k017-0060 526 µM 1.33275627627084 0.129999368474408 no 447 0.091305899311537 479 5512909
SGTC_455 paf C-16 10 µM 1.331624179303 0.130206625838912 no 448 0.0914918577170427 497 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis.
SGTC_3229 9132204 49.47 µM 1.33081256000441 0.130355352758874 no 449 0.0916253470671611 455 17682924
SGTC_2170 morpholine 200 µM 1.32944420103529 0.130606366629932 no 450 0.0918507316591095 508 121171 Reacts with secondary amines.
SGTC_1978 st071761 42 µM 1.31918899792016 0.132498234967238 no 451 0.0935529677595908 495 5147680
SGTC_613 3914-0030 117 µM 1.31267731969632 0.13370925720326 no 452 0.0946458516080001 270 1145395
SGTC_2954 9074818 52.69 µM 1.31037753057099 0.134138777792744 no 453 0.0950340755119141 535 16648742
SGTC_1386 3228-0095 33.8 µM 1.30963915306781 0.134276881809203 no 454 0.0951589683121181 511 870181
SGTC_1867 st057372 64 µM 1.30816722429854 0.134552478433618 no 455 0.0954082981475487 549 688837
SGTC_220 paclitaxel 373.376 µM 1.30523854358083 0.135101984249706 no 456 0.0959058166962879 478 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_856 0433-0016 11.3 µM 1.30382662752855 0.135367449863779 no 457 0.0961463507932797 574 3911780
SGTC_2793 7325131 81.82 µM 1.30370501210037 0.135390332463876 no 458 0.0961670899314661 492 4176441
SGTC_2233 sulbentine 40.3845 µM 1.30090324612766 0.135918234001602 no 459 0.0966457874315005 595 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58
SGTC_1822 st052468 42 µM 1.30011897448293 0.136066256577278 no 460 0.0967800976726589 512 2873678
SGTC_744 1594-0068 283 µM 1.29986081987483 0.136115004526816 no 461 0.0968243378454949 600 668392
SGTC_2731 amoxapine 43.43 µM 1.29749031837116 0.136563190812059 no 462 0.097231267091379 406 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine.
SGTC_970 1315-0089 19.5 µM 1.29660187744708 0.136731426392669 no 463 0.0973841030767054 522 6811083 YLR033W RSC58
SGTC_1454 4239-0054 42.6 µM 1.29556363952001 0.136928207075715 no 464 0.0975629314420806 601 1340767
SGTC_2328 6201408 200 µM 1.29518780172713 0.136999488550113 no 465 0.0976277258945979 536 2890418
SGTC_820 1582-0060 59.9 µM 1.29513063471351 0.137010333079224 no 466 0.0976375842544754 555 3848840
SGTC_3228 9131799 49.47 µM 1.29199652320986 0.137605768819463 no 467 0.0981791743191005 537 17015818
SGTC_461 N-acetylfarnesylcysteine 136 µM 1.29178352235161 0.137646299894855 no 468 0.098216061634935 477 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ).
SGTC_2039 Aminomethylbenzodioxan 200 µM 1.29022616776671 0.137942890191482 no 469 0.0984860715446718 499 15053
SGTC_2266 7929956 200 µM 1.28974019158621 0.138035531070093 no 470 0.0985704399327658 574 2967153
SGTC_2078 5212016 200 µM 1.28581612837595 0.138785123619003 no 471 0.0992536200391258 491 1899708
SGTC_388 3',4'-dichloroisocoumarin 16.7 µM 1.28397871515234 0.139137065958092 no 472 0.0995747015024841 553 1609 A potent and irreversible inhibitor of serine proteases.
SGTC_2601 securinine 100 µM 1.28278246171264 0.139366525282658 no 473 0.0997841501219547 553 442872 A GABA receptor antagonist.
SGTC_723 4182-0001 115 µM 1.28014452871797 0.139873429712063 no 474 0.100247155301573 531 744821 YLR208W SEC13
SGTC_2961 9083290 32.55 µM 1.27705927635228 0.140467878975617 no 475 0.100790660376005 511 17741490
SGTC_2197 6588183 93.1375 µM 1.27595089034883 0.140681854798352 no 476 0.100986439884692 501 884136
SGTC_2008 4012253 172 µM 1.27465921062502 0.140931494757553 no 477 0.10121494504335 575 603940
SGTC_825 1988-2224 89.6 µM 1.27296220914129 0.141259926790965 no 478 0.101515726161728 602 1180859
SGTC_1807 st050092 58.9 µM 1.27158570819124 0.141526711055461 no 479 0.101760178662083 549 5008496
SGTC_1720 st037298 9.481 µM 1.27090074949358 0.141659592324838 no 480 0.101881979879015 526 597396
SGTC_2349 9023730 187.07 µM 1.26907771134167 0.142013671525808 no 481 0.102206674441121 549 4126287
SGTC_1812 st052057 4.327 µM 1.26638567033778 0.14253762735091 no 482 0.102687519335192 591 3645418
SGTC_2062 5245942 200 µM 1.26420610097536 0.142962796649678 no 483 0.103078030805687 598 1376160
SGTC_1998 st075797 76.8 µM 1.26305263375723 0.143188150304198 no 484 0.10328513242111 623 24208315
SGTC_2045 5106652 78.05 µM 1.26136744624452 0.143517817641434 no 485 0.103588245691264 548 673349
SGTC_3256 9138902 49.47 µM 1.26079281343499 0.143630348097848 no 486 0.103691751855904 556 17228773
SGTC_1264 0783-0040 158 µM 1.26039022608957 0.143709222322314 no 487 0.103764312890305 527 2855798
SGTC_1758 st042942 75.2445 µM 1.25701600189577 0.144371443548155 no 488 0.104373920622164 567 669317
SGTC_782 0083-0095 30.5 µM 1.25236716309652 0.145287182900451 no 489 0.105218052931657 637 3591729 An indicator and reagent.
SGTC_2719 novobiocin 32.65 µM 1.24997511598175 0.145759893507015 no 490 0.105654318780716 495 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication.
SGTC_3031 9088762 49.47 µM 1.24963330913363 0.145827524879476 no 491 0.105716764768685 593 205253
SGTC_3120 9124077 49.47 µM 1.24904867012315 0.14594325294937 no 492 0.105823636527643 580 18774327 YGL155W CDC43
SGTC_3276 9139060 49.47 µM 1.24698760997728 0.146351727660414 no 493 0.106201020321273 527 4870619
SGTC_2388 9080168 200 µM 1.2468044932088 0.146388056062411 no 494 0.106234596290661 543 15943073
SGTC_924 2046-0044 21.3 µM 1.24640433914714 0.146467463403675 no 495 0.106307994520036 583 3623589
SGTC_3192 9110362 49.47 µM 1.2457090766819 0.14660550137717 no 496 0.106435610071525 602 16649480
SGTC_1433 4060-0023 7.6 µM 1.24567360905189 0.146612545488932 no 497 0.106442123125428 601 3840627
SGTC_1549 4'-methoxyflavonol 74.6 µM 1.24301206901064 0.147141793476596 no 498 0.106931693037522 589 97141
SGTC_599 1935-0052 86.5 µM 1.24107131598026 0.14752851929737 no 499 0.10728970238837 614 9557311
SGTC_484 loperamide 105 µM 1.23981110140738 0.147780001348888 no 500 0.107522635558212 482 3955 An opioid-receptor agonist.
SGTC_3264 9137442 49.47 µM 1.23967533352651 0.147807111619444 no 501 0.107547752096216 551 17015726
SGTC_330 1488-0319 80.1 µM 1.23913906462982 0.147914226898516 no 502 0.107647001119531 587 6846614
SGTC_1471 k673-0312 37 µM 1.2353054712649 0.148681468801999 no 503 0.108358419132281 565 24099884
SGTC_385 1494-0393 12.4 µM 1.23473327572542 0.148796213766601 no 504 0.108464893665591 598 3090647
SGTC_2528 xanthyletin 44.79 µM 1.2314662467845 0.149452499290943 no 505 0.109074266603507 568 65188 An natural product with antifungal activity of unknown mechanism.
SGTC_1197 1601-0112 267 µM 1.23025085649747 0.149697141000958 no 506 0.109301590450493 630 7350313
SGTC_1784 st039334 36.3 µM 1.2292540514035 0.149897983760826 no 507 0.109488284503596 593 3496984
SGTC_1477 0139-0234 16 µM 1.22867562674288 0.150014610873823 no 508 0.109596724012072 592 620880
SGTC_859 0439-0102 54.6 µM 1.22837524017953 0.150075201340487 no 509 0.10965306905617 656 610143
SGTC_2883 9059145 45.46 µM 1.22650886028292 0.150452031248484 no 510 0.11000362156148 559 16476510
SGTC_460 trequinsin 123 µM 1.22453962827967 0.150850310276138 no 511 0.110374363267848 639 5537 A vasodilator.
SGTC_2555 cholic acid 100 µM 1.22341556370878 0.151077967768965 no 512 0.110586388946167 598 6708657 Influences liver metabolism.
SGTC_149 3970-0822 46.1 µM 1.22155864810394 0.15145455055935 no 513 0.110937287193942 752 3114250 YBL034C STU1
SGTC_600 1495-0418 41.6 µM 1.22108491297389 0.151550723963725 no 514 0.111026935687269 582 5377768
SGTC_438 sphingosine 6.67 µM 1.22099030527187 0.151569935222762 no 515 0.111044845234489 497 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes.
SGTC_1896 st058441 89 µM 1.22001126488565 0.151768836489431 no 516 0.111230302280504 555 688759
SGTC_1274 0865-0114 173 µM 1.21940911227118 0.151891255564999 no 517 0.111344476546204 597 870624
SGTC_1337 1486-1011 40.3 µM 1.21937358246673 0.151898480908787 no 518 0.11135121597885 582 X1337
SGTC_2680 butyl paraben 22.24 µM 1.21904475465617 0.151965362193527 no 519 0.111413603184221 558 7184 An antifungal and steroid mimetic.
SGTC_668 1682-0499 62.6 µM 1.21234581066943 0.153332138957898 no 520 0.112690017396884 654 682214
SGTC_767 0929-0023 86 µM 1.21227743531779 0.15334613134825 no 521 0.112703099225449 705 1204563
SGTC_347 4534-1311 26.2 µM 1.21067474779128 0.153674348985599 no 522 0.113010042071125 614 2862016
SGTC_2225 6654152 15.4 µM 1.20831225124962 0.154159016986211 no 523 0.113463588891844 537 97582 YGR029W | YLR033W ERV1 | RSC58
SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM 1.20625045234611 0.154582821987137 no 524 0.113860467932782 677 4174840
SGTC_1425 4048-4433 7.33 µM 1.20622343362417 0.154588380821381 no 525 0.113865675369366 654 23734946
SGTC_1735 st034310 56.75 µM 1.20621796620044 0.154589505705696 no 526 0.113866729150528 617 871153
SGTC_585 0kpi-0023 191 µM 1.20400505118868 0.155045241752545 no 527 0.114293813109924 578 64601
SGTC_783 0848-0141 92.7 µM 1.20346864052495 0.155155845635024 no 528 0.114397509811414 580 6755076 YHR007C | YLR033W ERG11 | RSC58
SGTC_1175 0741-0056 27.6 µM 1.20128639224638 0.155606345850867 no 529 0.114820063559901 693 765927
SGTC_1674 st016616 23.6 µM 1.20105422457564 0.155654324940277 no 530 0.114865083983396 611 625830
SGTC_579 4491-1009 110 µM 1.20052544907154 0.155763636547316 no 531 0.114967667505825 787 1271041
SGTC_3246 9135460 32.98 µM 1.19862934287355 0.15615602696202 no 532 0.115336051648961 535 41446951
SGTC_1214 0358-0031 63.7 µM 1.19797477605708 0.156291637638816 no 533 0.115463418463868 613 4301366
SGTC_698 k064-0052 127 µM 1.19774909298748 0.156338411782419 no 534 0.115507355452403 573 5088751
SGTC_2202 7226349 200 µM 1.19542051259185 0.156821562066713 no 535 0.11596138762389 586 844334
SGTC_3191 9110352 49.47 µM 1.18457982616068 0.15908378549422 no 536 0.118091808640648 608 17122424
SGTC_1113 artemisinin 1.17947 µM 1.1834784175662 0.159314816821239 no 537 0.118309797549884 665 2240 An anti-malaria and mitochondrial poison.
SGTC_2621 lithochol-11-enic acid 100 µM 1.18250764808601 0.159518627376381 no 538 0.118502166330122 669 6708711
SGTC_1746 st038117 42 µM 1.1795569146301 0.160139173592569 no 539 0.119088243829766 655 2898218
SGTC_2224 6650123 117.647 µM 1.17893387590768 0.160270401634267 no 540 0.119212253592421 596 2908370
SGTC_679 0422-0091 41.4 µM 1.17775265467733 0.160519390216063 no 541 0.119447614282111 666 627384 YHR062C RPP1
SGTC_2138 5575593 77.673 µM 1.17396581917573 0.161319316621684 no 542 0.12020435842814 596 762213
SGTC_301 4119-0100 24.5 µM 1.17290022684157 0.161544878976126 no 543 0.120417909295888 692 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1
SGTC_1374 2889-5571 141 µM 1.17267971210786 0.16159158273937 no 544 0.120462135073524 687 2853281
SGTC_2728 chlorpromazine 9.18 µM 1.16845004768734 0.162489104921915 no 545 0.12131263864358 536 2726 A thorazine and dopamine antagonist.
SGTC_2136 5328288 199.296 µM 1.16694620316182 0.162808996489338 no 546 0.121616047777043 564 262395
SGTC_59 0330-0160 1.33 µM 1.16397908612341 0.163441349658636 no 547 0.122216243661741 790 4293482
SGTC_2108 5365811 200 µM 1.16316784361322 0.16361451931876 no 548 0.122380705228795 655 780283
SGTC_3290 9121031 71.43 µM 1.16150177484185 0.163970535540682 no 549 0.122718950911798 587 17014854
SGTC_3315 9136395 68.55 µM 1.15945955357164 0.164407615559476 no 550 0.123134456969484 703 16876844
SGTC_1621 st003705 32.4 µM 1.15912278994387 0.164479762816507 no 551 0.123203068783848 715 24207032
SGTC_219 mitoxanthrone 164.414 µM 1.15866793853639 0.164577241426483 no 552 0.123295782184897 644 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA. YMR168C CEP3
SGTC_3275 9138069 49.47 µM 1.15676965861908 0.164984463370834 no 553 0.123683240611961 626 17617007
SGTC_3206 9114350 49.47 µM 1.15648874498902 0.165044780769332 no 554 0.123740650305634 619 17087243
SGTC_55 0767-0285 6.563 µM 1.15437201455443 0.165499741326748 no 555 0.12417384175535 701 3116166
SGTC_2028 5153890 36.43 µM 1.14963560523518 0.166520699425476 no 556 0.125146993459238 654 2830968 YPR165W RHO1
SGTC_1452 4194-0072 190 µM 1.14554578938959 0.167405544780084 no 557 0.125991569442043 724 1343545
SGTC_979 1426-2828 121 µM 1.1449106660659 0.167543227127865 no 558 0.126123082587991 708 747872
SGTC_1286 0929-0070 131 µM 1.14381666438083 0.167780556343682 no 559 0.126349838668909 693 1420408
SGTC_3198 9112019 49.47 µM 1.14357703414166 0.167832569844913 no 560 0.126399545247541 638 45595555
SGTC_838 0109-0203 71.4 µM 1.14199475833026 0.16817627496541 no 561 0.126728099236055 692 759422
SGTC_1473 k844-0725 134 µM 1.14174005664174 0.16823164406225 no 562 0.12678104266107 759 54682906
SGTC_2390 9097792 176.6 µM 1.13970608071746 0.168674226750714 no 563 0.127204386496643 626 4497149
SGTC_3309 9129340 25.759 µM 1.13813991511139 0.16901552581798 no 564 0.127531031616609 721 17158987
SGTC_1314 1222-0010 41.1 µM 1.13795850984337 0.169055086327553 no 565 0.1275689038055 671 3526027
SGTC_1211 1056-0033 32.3 µM 1.13717306095861 0.169226444110612 no 566 0.127732973105306 694 6741922
SGTC_792 4534-1957 155 µM 1.13517991007311 0.169661781026148 no 567 0.128149972611205 679 1717904
SGTC_2624 nerol 100 µM 1.13488826565428 0.169725541154726 no 568 0.128211068562108 650 637566 A natural product oil.
SGTC_1458 k015-0034 6.33 µM 1.13364090666631 0.169998415704874 no 569 0.128472603320829 636 3598957
SGTC_2568 diosmetin 100 µM 1.13262301777249 0.17022129920962 no 570 0.128686299120457 710 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.
SGTC_414 piperonyl butoxide 100 µM 1.13180030677745 0.170401582062262 no 571 0.128859199368849 662 5794 A potent inhibitor of cytochrome P450.
SGTC_854 0422-0053 192 µM 1.13034591856501 0.170720585091711 no 572 0.129165246439856 662 3596728
SGTC_315 k915-0449 187 µM 1.1301544847534 0.17076260230686 no 573 0.129205567375368 774 20970215 YNL149C PGA2
SGTC_273 hydroxyurea 18.1 mM 1.12891816328651 0.171034118056938 no 574 0.129466178934984 747 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12
SGTC_1002 4049-0206 172 µM 1.12844076056133 0.171139037111812 no 575 0.129566910905061 721 4662749
SGTC_2178 5812956 200 µM 1.12634855152038 0.171599328351885 no 576 0.13000900728177 658 5403383
SGTC_134 0269-0018 6.916 µM 1.12597089612008 0.171682497684156 no 577 0.130088919259217 693 4378915
SGTC_1819 st053448 58.6 µM 1.12491828001987 0.171914446426719 no 578 0.130311832488004 676 2857616
SGTC_2730 imipramine 71.33 µM 1.12462045299538 0.171980110264359 no 579 0.130374951452249 804 3696 A tricyclic antidepressant.
SGTC_479 n-linoleoylglycine 10 µM 1.12328482137844 0.172274782432941 no 580 0.130658274087252 651 6433346 An anti-infammatory.
SGTC_1021 4476-0760 85.3 µM 1.12297977820788 0.172342127388899 no 581 0.130723041442269 669 746768
SGTC_1387 3342-1166 1.8 µM 1.12080104767902 0.172823618095773 no 582 0.131186279056711 609 3418228
SGTC_3310 9130229 44.1445 µM 1.11855433217815 0.173321030165937 no 583 0.131665157650088 671 7761258
SGTC_966 1300-0360 30.2 µM 1.11657335427313 0.173760364562962 no 584 0.13208839491377 685 70588
SGTC_982 1491-0518 27.5 µM 1.11331238975465 0.174485111265301 no 585 0.132787143545112 636 3091256
SGTC_630 4356-0227 183 µM 1.11252270796781 0.174660905757805 no 586 0.132956736095969 667 779312
SGTC_3094 9117742 49.47 µM 1.11237111781587 0.17469466476099 no 587 0.132989308743725 725 17149698
SGTC_1026 k007-1105 30.6 µM 1.11219769655951 0.174733290613424 no 588 0.133026579045424 760 7066794
SGTC_2996 9066192 71.4286 µM 1.11181148925824 0.174819329457314 no 589 0.133109605445976 670 6472854
SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM 1.10781237002176 0.175711829238535 no 590 0.133971428336887 644 2374 Ca(2+)-ATPase inhibitor.
SGTC_805 3852-0218 479 µM 1.10747609219516 0.175787009084607 no 591 0.134044071645379 670 6615355
SGTC_2706 st078239 82.5 µM 1.10703494428845 0.175885665070037 no 592 0.134139410199664 704 15434492
SGTC_1702 st027038 51 µM 1.10417072792057 0.176527055937102 no 593 0.134759542473308 717 5521182
SGTC_101 0490-5701 117.494 µM 1.10340813472145 0.176698074323239 no 594 0.134924982813417 647 4661669
SGTC_1676 st018489 23.4 µM 1.10215238493553 0.176979915695041 no 595 0.135197714217328 699 3696235
SGTC_969 1313-0238 134 µM 1.10180515151046 0.177057899117406 no 596 0.135273195152763 742 5212874
SGTC_3145 9085516 49.47 µM 1.10060276040108 0.177328105848083 no 597 0.135534791811646 674 25236195
SGTC_2808 7946468 45.46 µM 1.10018664227188 0.177421678398505 no 598 0.135625404695004 743 2970879
SGTC_2016 5121758 140 µM 1.09881707100731 0.177729874189927 no 599 0.13592393228012 759 2795203
SGTC_2168 5727979 200 µM 1.09822887387861 0.177862340309122 no 600 0.136052280527715 634 695210
SGTC_1258 0671-0043 57.1 µM 1.09678754465974 0.178187200929478 no 601 0.13636713810005 695 4298767
SGTC_799 1310-0557 151 µM 1.09650125174571 0.178251772868711 no 602 0.136429737923703 700 5354492
SGTC_3352 9151559 45.5865 µM 1.0962854539578 0.178300454729662 no 603 0.13647693651644 670 17159339
SGTC_1885 st057546 99.9 µM 1.0955127973571 0.178474827160836 no 604 0.136646021040551 738 702008
SGTC_2316 5844804 197.44 µM 1.09457299311848 0.178687066056248 no 605 0.136851876362149 850 776813
SGTC_1755 st041960 45.185 µM 1.09416714213432 0.178778769749779 no 606 0.136940839722528 703 2257073
SGTC_1767 st044992 70.3 µM 1.09278835440961 0.179090533733666 no 607 0.137243367960274 695 9600693
SGTC_2073 5212005 126 µM 1.09110180371554 0.179472352169673 no 608 0.137614044630777 623 691789
SGTC_2642 cholecalciferol 100 µM 1.08952049167991 0.179830810057867 no 609 0.137962211707744 710 9821465 A vitamin D precursor, similar to steriods.
SGTC_2015 5119600 184 µM 1.08870412018701 0.180016044176121 no 610 0.138142192147466 734 2828786
SGTC_631 k072-0230 41.5 µM 1.08867510782485 0.180022629264395 no 611 0.138148591270465 762 5773147
SGTC_2775 cyproheptadine 69.59 µM 1.08856030542358 0.180048688051954 no 612 0.138173914689268 730 2913 A selective serotonin reuptake inhibitor.
SGTC_2116 5511452 16.8835 µM 1.08745422434267 0.180299876695558 no 613 0.138418059140014 727 870744
SGTC_1414 3917-0015 5.4 µM 1.08672561366023 0.180465462702328 no 614 0.138579045359954 700 6618702
SGTC_2243 6634756 200 µM 1.08410998248272 0.181060683602394 no 615 0.139158018643925 680 885676
SGTC_1601 4'-hydroxyflavanone 55.5 µM 1.0840580003878 0.181072525255666 no 616 0.139169541606008 775 165506
SGTC_2614 arthonioic acid 13.39 µM 1.08346713132699 0.181207160829625 no 617 0.139300566227688 660 6710684
SGTC_907 3448-6986 75.5 µM 1.08339796908283 0.181222924254201 no 618 0.139315908371367 791 590582
SGTC_2917 7979103 53.79 µM 1.08119522557793 0.181725421662274 no 619 0.139805140681863 773 2980565
SGTC_2155 5570423 76 µM 1.07952832984776 0.182106258486527 no 620 0.140176135847609 690 797402
SGTC_1009 4106-0057 9.87 µM 1.07913463386055 0.182196279266136 no 621 0.140263856928838 767 2928005
SGTC_2990 9074105 71.4286 µM 1.07868939062053 0.18229812012031 no 622 0.140363108390119 686 6502001
SGTC_3163 9099914 49.47 µM 1.07818439619204 0.18241367095683 no 623 0.140475737003477 689 16268368
SGTC_2635 hydroquinidine 100 µM 1.07808402819458 0.182436642216502 no 624 0.140498129326618 735 442912 An experimental heart treatment.
SGTC_8 0354-0001 70 µM 1.07744164878846 0.182583706614543 no 625 0.140641502983273 826 4993152
SGTC_2991 9074669 71.4286 µM 1.07735998504533 0.182602407767681 no 626 0.140659736752548 771 17333109
SGTC_2606 farnesol 9.78 µM 1.07710541662122 0.18266071209893 no 627 0.140716586738792 739 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_812 4251-0442 148 µM 1.07525658304924 0.183084502967019 no 628 0.141129934359148 713 5723007
SGTC_636 0kpi-0074 126 µM 1.07420225734505 0.183326450620178 no 629 0.141366020445049 696 616434
SGTC_688 0527-0193 473 µM 1.07247668303534 0.183722866965156 no 630 0.141752990720999 700 4007154
SGTC_3279 9140807 49.47 µM 1.07239818395359 0.183740913256999 no 631 0.141770611650464 738 45595718
SGTC_2409 alverine citrate 63.97 µM 1.07079168323059 0.184110477054857 no 632 0.142131553643207 714 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_2897 9048598 12.99 µM 1.06959946517706 0.184385037030847 no 633 0.1423998180143 681 6467404
SGTC_2058 5236698 133 µM 1.06851680472179 0.184634587181711 no 634 0.142643727086592 713 766665
SGTC_2677 mitomycin C 100 µM 1.06679822400444 0.185031146171126 no 635 0.143031480368058 686 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_1316 1272-0050 65.9 µM 1.06584125977561 0.185252192900035 no 636 0.143247703001742 726 7340392
SGTC_2811 7967822 32.47 µM 1.06511373285531 0.18542035216486 no 637 0.143412232738495 735 2232244
SGTC_3167 9103034 49.47 µM 1.06447886121939 0.185567172649402 no 638 0.143555912755406 684 5127859
SGTC_1740 st038286 13.222 µM 1.06422490205471 0.185625923469782 no 639 0.143613414339007 721 716786
SGTC_54 0159-0055 9 µM 1.06223112086549 0.186087564970337 no 640 0.14406538749837 736 3319099
SGTC_1870 st057514 26.5 µM 1.05594012253255 0.187548846829591 no 641 0.145497785932513 723 5393161
SGTC_3131 9127911 49.47 µM 1.05583182500561 0.187574064254284 no 642 0.145522527783716 710 45595681
SGTC_727 3032-0951 202 µM 1.05439352250487 0.187909176237974 no 643 0.145851393324857 721 3652836
SGTC_351 caspofungin 25 nM 1.05425349901763 0.187941820228018 no 644 0.145883436128047 873 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1
SGTC_2710 st078562 53.7235 µM 1.05421658925567 0.187950425666794 no 645 0.145891883300551 739 17250908
SGTC_1842 st055362 61.2 µM 1.05398016028208 0.188005554389198 no 646 0.145946000259723 779 676032
SGTC_1524 corynanthine 62.1 µM 1.05281083244249 0.18827835616907 no 647 0.146213849638706 724 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist.
SGTC_214 4373-3496 70 µM 1.0490770182329 0.189151081099895 no 648 0.147071336217055 932 3779166
SGTC_1994 st072947 40.9 µM 1.04863625433242 0.189254267409309 no 649 0.147172781615245 762 5286565 YDL195W SEC31
SGTC_1287 0971-0001 34.6 µM 1.04781496127174 0.189446631029507 no 650 0.147361934009443 803 4665869
SGTC_1332 1480-0653 17.5 µM 1.04736795494148 0.189551379597155 no 651 0.147464952685448 752 5749438
SGTC_1935 st074532 41.6 µM 1.04730774847445 0.189565490713127 no 652 0.147478831769347 842 2829742
SGTC_1159 4092-0538 61.2 µM 1.04378879041019 0.190391382216411 no 653 0.148291559487394 802 717301
SGTC_2838 9002687 71.43 µM 1.04218503518985 0.190768511880065 no 654 0.148662949886145 700 6457060
SGTC_1206 3978-0017 132 µM 1.03977124223207 0.191336988732767 no 655 0.149223096396507 710 3873677
SGTC_2005 4024620 188 µM 1.03766390205445 0.191834140254354 no 656 0.149713278144207 766 236743
SGTC_1437 4092-1038 11.6 µM 1.03713201541223 0.191959744760924 no 657 0.149837168208417 803 3977136
SGTC_1036 k216-0215 33.5 µM 1.03581922139969 0.19226997514417 no 658 0.150143244257438 771 622330
SGTC_2099 5377090 177.372 µM 1.03508015352007 0.192444761381117 no 659 0.150315740113074 754 2243829
SGTC_1949 st076024 69.1 µM 1.03374231019992 0.192761402314176 no 660 0.150628323823764 733 2921930
SGTC_3109 9122853 49.47 µM 1.02879368895256 0.193935406389811 no 661 0.151788316498276 827 1234709
SGTC_1582 3',3',6'-trihydroxyflavone 74 µM 1.02855359755754 0.193992475954423 no 662 0.151844746242434 729 688803
SGTC_2629 bisabolol 100 µM 1.0284388452133 0.194019756124084 no 663 0.151871721916678 799 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer.
SGTC_2372 9071633 200 µM 1.02772974315414 0.194188383386653 no 664 0.152038486356092 853 21321366
SGTC_483 fpl-64176 144 µM 1.02587427931714 0.194630042181904 no 665 0.152475423906715 719 3423
SGTC_1761 st044296 37 µM 1.0206308009141 0.195881455412945 no 666 0.153714695442368 759 1826700
SGTC_1186 1319-0216 26 µM 1.01995092714977 0.19604407150633 no 667 0.153875867404736 831 4565136
SGTC_3146 9095609 49.47 µM 1.0195184976078 0.196147545069197 no 668 0.153978438013729 781 17173999
SGTC_1218 1348-1416 30.7 µM 1.01803744679631 0.19650218804322 no 669 0.154330080260555 761 6787668
SGTC_3268 9137683 49.47 µM 1.01743120630909 0.196647466523139 no 670 0.154474171490256 764 1953228
SGTC_2358 9037157 4 µM 1.0163328015064 0.196910852135235 no 671 0.154735466791584 781 2388925
SGTC_463 ikarugamyin 104 µM 1.01347378615653 0.197597413880893 no 672 0.155416955505522 755 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis.
SGTC_168 3970-0862 530.542 µM 1.00867654563647 0.198752665476783 no 673 0.156564891857178 927 3135186
SGTC_2881 9058953 51.95 µM 1.00733863216852 0.199075581053292 no 674 0.156886035460114 854 17122249
SGTC_2855 9016525 58.44 µM 1.00483362272864 0.199681033422884 no 675 0.157488485417716 790 43811474
SGTC_420 mitomycin C 81.9 mM 1.00297175147387 0.20013175838093 no 676 0.157937245531516 796 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_157 1348-1695 65.819 µM 1.00175225241526 0.20042730794642 no 677 0.158231631616875 813 5380510
SGTC_2280 7785178 200 µM 1.0013879438865 0.200515650135653 no 678 0.158319645208353 771 2954328
SGTC_3006 9075424 71.4286 µM 1.00079043686161 0.200660591895016 no 679 0.158464066941855 754 7465181
SGTC_381 3461-2219 42.7 µM 1.00033907459209 0.200770123917124 no 680 0.15857322171662 830 2883159
SGTC_471 1-acyl-paf 4 µM 1.00016706035762 0.200811876030644 no 681 0.158614833592286 778 16759367
SGTC_1130 3454-2858 15.9 µM 0.997920494538606 0.201357651479938 no 682 0.159158956556415 770 715628 YIL048W NEO1
SGTC_1041 0206-0046 107 µM 0.996911442363496 0.201603077336933 no 683 0.159403748560794 799 50494
SGTC_2844 9010103 25.97 µM 0.996590997685955 0.201681054696856 no 684 0.159481538695349 768 2480525
SGTC_379 3970-0972 5.9 µM 0.994795734119349 0.202118250110877 no 685 0.159917810716313 794 2898042 YBL034C STU1
SGTC_2459 5811157 9.22 µM 0.99126807458368 0.202978981217196 no 686 0.160777348846484 823 2870684 YBR192W RIM2
SGTC_2727 riluzole 51.77 µM 0.990308242874415 0.203213553591887 no 687 0.161011739420721 750 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.
SGTC_1184 1269-1718 139 µM 0.990077530995541 0.203269961163555 no 688 0.161068112410802 822 5403821
SGTC_2755 lomerizine 42.69 µM 0.98924229331631 0.203474249544835 no 689 0.16127230516586 819 3949 A calcium channel blocker.
SGTC_2924 9010168 62.78 µM 0.987030345895596 0.204015854726719 no 690 0.161813881140836 796 2993929
SGTC_3095 9117207 49.47 µM 0.986418597868639 0.204165795441933 no 691 0.16196387124981 761 17015229
SGTC_99 0109-0120 622.8 µM 0.986043873312367 0.204257673616823 no 692 0.162055791989543 774 759414
SGTC_1958 st076513 41.9 µM 0.985186766485083 0.204467918945725 no 693 0.162266169850123 793 732122 YGL099W LSG1
SGTC_2878 9043973 25.97 µM 0.982545582803146 0.205116601612123 no 694 0.162915569027363 786 6465167
SGTC_327 1273-0057 3.96 µM 0.982493410774284 0.205129427525346 no 695 0.162928413784095 787 3108138
SGTC_338 4055-0136 114 µM 0.982058557188375 0.205236349985025 no 696 0.163035500378695 807 2900563
SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM 0.9811108774942 0.205469481587928 no 697 0.163269033463197 800 7104
SGTC_1042 0350-0096 82 µM 0.978973138295922 0.20599594794039 no 698 0.163796626061013 781 3122515
SGTC_1173 0443-0020 122 µM 0.977750812814353 0.206297332251093 no 699 0.164098791851638 809 5331295
SGTC_2120 5538279 151.968 µM 0.969603365727185 0.208312885517223 no 700 0.166122117308052 836 2058197
SGTC_962 1254-0300 21.5 µM 0.969593397264771 0.208315358655655 no 701 0.166124602692381 832 7340576
SGTC_1921 5740136 50 µM 0.968817817691013 0.208507830155546 no 702 0.166318047511146 870 1774243
SGTC_2270 7924575 90.91 µM 0.967324052852019 0.208878825240592 no 703 0.166691031593015 857 1262135
SGTC_1984 st072354 53.1 µM 0.966681533020366 0.209038522576222 no 704 0.166851630813476 827 5762938
SGTC_225 nsc-122657 1.016 µM 0.96577933607354 0.20926288359452 no 705 0.167077305309739 707 275685
SGTC_421 streptovitacin 30 mM 0.965114709656676 0.209428255500534 no 706 0.16724368002948 865 91467 include heat shock
SGTC_71 0417-1750 47.813 µM 0.964698864036223 0.209531765028849 no 707 0.167347832199119 875 6811472
SGTC_1963 st076565 50.3 µM 0.962733218477251 0.21002144762684 no 708 0.167840710924345 823 4914280
SGTC_2984 9022109 38.96 µM 0.962579758202498 0.210059706003584 no 709 0.167879229840394 820 6459207
SGTC_2937 9044753 11.33 µM 0.960164645528509 0.210662344180937 no 710 0.16848617862569 883 6465530 YGL099W LSG1
SGTC_1321 1326-2144 215 µM 0.958117507288288 0.211173955828306 no 711 0.169001754133204 851 3513030
SGTC_2445 5742597 35.57 µM 0.957645178495307 0.211292101422401 no 712 0.169120854728052 801 1774255
SGTC_1628 st004252 77.7 µM 0.957345983624937 0.211366960326784 no 713 0.169196326422205 855 692968
SGTC_3172 9105863 49.47 µM 0.957019233735795 0.211448731272613 no 714 0.169278773549488 801 2348785
SGTC_2957 9076800 11.52 µM 0.956815905848446 0.21149962453724 no 715 0.169330091250087 759 16459615
SGTC_2385 9074692 200 µM 0.956049420254766 0.211691541462538 no 716 0.169523633463999 850 17046906
SGTC_1381 2324-0066 62.1 µM 0.954444263912779 0.212093779496044 no 717 0.169929404736613 801 10885928
SGTC_3328 9140624 29.0385 µM 0.954154349259433 0.212166477171697 no 718 0.170002759281481 872 4904392
SGTC_1520 flindersine 88 µM 0.953509249622508 0.212328291674594 no 719 0.170166055965735 867 68230 Flindersine is a natural alkaloid of the quinoline subtype.
SGTC_980 1473-0395 201 µM 0.953434139025403 0.212347136836536 no 720 0.170185075545951 779 768876
SGTC_504 lovastatin 124 µM 0.953152654291679 0.212417769725316 no 721 0.170256365507849 783 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1
SGTC_3294 9122953 26.2835 µM 0.951344282371792 0.212871871273593 no 722 0.170714817284152 869 16459826
SGTC_3220 9131269 49.47 µM 0.949840953367939 0.213249804200832 no 723 0.171096536598393 836 17722206
SGTC_1290 0986-0249 10.2 µM 0.948021443815521 0.21370774702963 no 724 0.17155926881009 809 53329
SGTC_2732 terfenadine 20 µM 0.946703450935943 0.214039823210798 no 725 0.171894955739746 833 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.
SGTC_1545 lovastatin 49.4 µM 0.944513086706824 0.21459236236156 no 726 0.172453758781232 911 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12
SGTC_1613 st002381 52.1 µM 0.943813405810878 0.214769037754401 no 727 0.172632504407878 905 551167
SGTC_359 0081-0058 15.9 µM 0.941709842744216 0.215300714094598 no 728 0.17317060719204 789 3494159
SGTC_2623 humulene 100 µM 0.940641727832553 0.215570972640391 no 729 0.173444245212806 726 6187145 An anti-inflammatory.
SGTC_2560 caryophyllene 100 µM 0.939022812397475 0.215980971693435 no 730 0.173859516007836 978 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor.
SGTC_885 0865-0106 16.8 µM 0.937752146183861 0.216303090964465 no 731 0.174185899337246 857 2793380
SGTC_1966 st070145 16.1 µM 0.937283232331917 0.216422032830138 no 732 0.17430644285415 835 3748532
SGTC_1012 4112-3522 18 µM 0.935062555211223 0.216985830267806 no 733 0.174878031187635 908 3112398
SGTC_685 1278-0033 54.9 µM 0.934351844893982 0.217166448370663 no 734 0.175061214545352 891 3590572
SGTC_1725 st036284 20.55 µM 0.934130242521177 0.217222783588912 no 735 0.175118356749186 943 707914
SGTC_879 0831-1030 162 µM 0.933428902270116 0.217401132231252 no 736 0.175299281728801 887 1549252
SGTC_311 1315-0136 58 µM 0.93310726531492 0.217482951776318 no 737 0.175382294149972 872 6759207
SGTC_1605 st000082 49.1 µM 0.932943008758843 0.217524742999568 no 738 0.175424697318348 886 1114022
SGTC_1358 1509-0022 2.48 µM 0.931656782025712 0.217852153406618 no 739 0.175756964067751 900 3258434
SGTC_2198 6589944 200 µM 0.931595808009534 0.217867681461384 no 740 0.175772725177526 792 5290268
SGTC_286 k060-0067 22.9 µM 0.931573130461589 0.217873456841749 no 741 0.175778587301629 851 5985051
SGTC_2875 9039966 71.43 µM 0.930117586241769 0.21824433067651 no 742 0.17615510311914 889 6463691
SGTC_595 3909-8003 73.7 µM 0.929310752414531 0.218450069191267 no 743 0.176364032222836 876 699517
SGTC_2663 amphotericin b 100 µM 0.928939534136819 0.218544765465826 no 744 0.176460211598 853 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_760 0568-0725 82.9 µM 0.92715138620148 0.219001245747995 no 745 0.17692396963788 939 3916171
SGTC_1331 1472-0049 76.2 µM 0.926945810442249 0.21905376046686 no 746 0.176977335248294 825 24051409
SGTC_445 e6 berbamine 66 µM 0.926655644681933 0.219127896185342 no 747 0.177052676967325 943 6610268 A calcium/calmodulin antagonist.
SGTC_1022 4477-0945 21.3 µM 0.925200018777936 0.219500018044598 no 748 0.177430936873225 879 4648966
SGTC_1389 3405-0187 19 µM 0.92223872737235 0.220258173466403 no 749 0.178202033283058 814 799890
SGTC_824 1304-0008 100 µM 0.92104164959493 0.22056507723674 no 750 0.178514341264114 882 768245
SGTC_2277 7947813 106.88 µM 0.91962146273807 0.220929498717632 no 751 0.178885303437387 857 1246798
SGTC_2264 7948757 110.76 µM 0.917373763568258 0.2215069645961 no 752 0.179473408071946 851 2971411
SGTC_1171 0368-0077 21.4 µM 0.917178301688431 0.221557222277889 no 753 0.179524607541864 842 3239779
SGTC_1859 st055998 20 µM 0.91641262609937 0.221754157594598 no 754 0.179725257736883 929 676301
SGTC_2458 5808907 16.39 µM 0.915460016327715 0.221999312801383 no 755 0.179975091846141 966 2731747
SGTC_2721 ifenprodil 61.44 µM 0.913763013661727 0.222436421502296 no 756 0.180420692507019 874 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor.
SGTC_803 4488-1585 147 µM 0.913610633798656 0.222475695038722 no 757 0.180460738401689 891 747204
SGTC_664 1222-0054 14.9 µM 0.912741320206962 0.222699822693127 no 758 0.180689303303516 895 6813991
SGTC_1102 cgs 12066b 26.1 µM 0.911938821223337 0.222906838299319 no 759 0.180900461975011 869 6438352 A 5-HT1B full agonist.
SGTC_1126 isoteolin 1.0172 µM 0.911878100070065 0.222922506612586 no 760 0.180916445604998 872 133323
SGTC_2826 7992541 19.48 µM 0.906577467124927 0.22429268254374 no 761 0.182315140969588 897 2985066
SGTC_470 aa-861 153 µM 0.905041331299116 0.22469065448543 no 762 0.182721745666724 904 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor.
SGTC_87 0100-0052 35.5 µM 0.90467632024519 0.22478527799716 no 763 0.182818444791969 1070 200187 YGR083C | YDR527W GCD2 | RBA50
SGTC_1390 3413-2614 145 µM 0.904011809643873 0.224957600166415 no 764 0.18299456965656 934 3421432
SGTC_789 1309-1135 70.6 µM 0.90234106846096 0.22539119060689 no 765 0.183437857906002 901 3092424
SGTC_469 w7 172 µM 0.90176591245955 0.225540564393928 no 766 0.183590615532565 891 45115570 A P450 inhibitor.
SGTC_1786 berberine 21.6 µM 0.900597705389498 0.225844131897453 no 767 0.183901127537363 851 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_1025 k007-0731 70 µM 0.898870934981279 0.226293269261308 no 768 0.18436070552326 900 6256118
SGTC_226 1,3-diallylurea 8.28947 mM 0.898038546968357 0.226509955603987 no 769 0.184582499672102 873 74537 YKL182W FAS1
SGTC_1179 1021-1431 9.29 µM 0.897372901524961 0.226683319966212 no 770 0.18475998373902 945 2840958
SGTC_2279 7948423 32.93 µM 0.897174337787845 0.226735049495386 no 771 0.184812948226138 897 1247112
SGTC_1037 k284-1091 78.7 µM 0.897076115255071 0.226760640745677 no 772 0.184839151393043 852 3334711
SGTC_2326 6164455 177.58 µM 0.896232498889688 0.226980506673208 no 773 0.185064300940248 850 2888790
SGTC_1629 st005085 44.9 µM 0.896223482068618 0.226982857314381 no 774 0.185066708325021 894 24207091
SGTC_2842 9000675 19.48 µM 0.895836223266632 0.227083826745894 no 775 0.185170120212937 857 2989072
SGTC_2117 5521686 200 µM 0.895528928960044 0.227163965164859 no 776 0.185252204266785 882 803312
SGTC_2303 7774051 200 µM 0.894885546949684 0.227331802568685 no 777 0.185424136794318 884 2953184
SGTC_1099 5-nonyloxytryptamine 2.85 µM 0.893176022296541 0.227778101142059 no 778 0.185881458251337 863 23581825 A 5-HT1D beta serotonin receptor agonist.
SGTC_830 4076-0286 57.8 µM 0.89298482410662 0.227828047108743 no 779 0.185932649862747 1018 6866659
SGTC_927 2425-1185 123 µM 0.889873305799023 0.228641722764563 no 780 0.186766959484757 886 730375
SGTC_2853 9015042 58.44 µM 0.88594066724617 0.229672455729652 no 781 0.187824750208436 892 6457456
SGTC_313 3474-0040 5.03 µM 0.885501543960468 0.229787709958053 no 782 0.187943093628043 913 1043375 YIL048W NEO1
SGTC_3188 9110789 49.47 µM 0.8835691264821 0.230295285399057 no 783 0.188464425657218 931 849217
SGTC_3077 9117319 49.47 µM 0.883070418910248 0.230426379361609 no 784 0.188599112775975 910 17154678
SGTC_2172 5754775 163.918 µM 0.880563499298535 0.231085998353334 no 785 0.189277060963872 845 2263357
SGTC_709 3807-1509 243 µM 0.880438499824132 0.231118915689929 no 786 0.189310903889781 951 1886677 YPL242C IQG1
SGTC_2537 larixol 68.93 µM 0.877387719495104 0.231923118358758 no 787 0.190138040553591 975 6708759
SGTC_981 1488-1094 54.9 µM 0.877062201281683 0.232009018685835 no 788 0.190226426949512 886 3449522
SGTC_1607 st000305 50.6 µM 0.876316266682861 0.232205928612955 no 789 0.190429062162496 951 5457690
SGTC_560 2332-1943 155 µM 0.875610211162204 0.232392397007553 no 790 0.1906209861777 927 21177716
SGTC_1420 4'-methoxyflavone 42 µM 0.875038448669327 0.232543459792188 no 791 0.190776492875793 959 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13
SGTC_1665 st014639 11.4 µM 0.874990912629876 0.232556021532239 no 792 0.190789425126804 997 981133 YIL048W NEO1
SGTC_2299 7976368 114.88 µM 0.874492720905421 0.232687694970175 no 793 0.190924991293084 936 2979718
SGTC_2142 5622915 118.518 µM 0.874155791625719 0.232776769785611 no 794 0.191016708780996 902 5322196
SGTC_701 4424-0219 185 µM 0.873490576081882 0.232952690063571 no 795 0.191197870317173 1010 2911779
SGTC_395 anisomycin 6.25 µM 0.872512304201678 0.233211534082922 no 796 0.191464479360356 890 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_2234 tolnaftate 200 µM 0.871122421126483 0.233579561968992 no 797 0.191843656542381 926 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7
SGTC_1518 st038567 90.8 µM 0.869291121521504 0.234064964119538 no 798 0.192343958925012 942 77966
SGTC_686 1319-0111 510 µM 0.867587217860766 0.234517100116167 no 799 0.192810173183209 988 4562600
SGTC_2321 7390090 138.78 µM 0.866754915562093 0.234738129568182 no 800 0.193038154651163 866 649046
SGTC_2689 tacrolimus 100 µM 0.86621548728229 0.234881443740446 no 801 0.19318600091843 911 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12).
SGTC_963 1269-2853 151 µM 0.864928888340992 0.235223459777119 no 802 0.193538910322906 923 3668223
SGTC_2773 thioridazine 9.09 µM 0.863307484055071 0.235654868335524 no 803 0.193984215222461 1023 5452 An antipsychotic.
SGTC_755 1995-0008 37.3 µM 0.862348229554578 0.235910303401681 no 804 0.194247960010223 971 689533
SGTC_2214 7179297 48.276 µM 0.861680802333067 0.236088119238816 no 805 0.194431596334279 970 769744
SGTC_999 SEC7.066 22.7 µM 0.861538344128412 0.236126082487479 no 806 0.194470806051104 1006 740511 YDR170C SEC7
SGTC_948 3448-0295 75.3 µM 0.861262111455779 0.236199704463905 no 807 0.194546849115539 979 678569
SGTC_3043 9092303 49.47 µM 0.860289126793117 0.236459126568611 no 808 0.194814842539423 934 25236084
SGTC_3238 9133470 49.47 µM 0.85991067513194 0.236560073615418 no 809 0.194919141760992 954 3534688
SGTC_1670 st016595 4.04 µM 0.857336183700296 0.237247414594393 no 810 0.195629558382483 1003 597879
SGTC_2057 5236571 38.335 µM 0.856635116010677 0.237434776380881 no 811 0.195823286109291 981 54684039 YBR257W POP4
SGTC_947 3447-0010 211 µM 0.856624539929771 0.237437603482147 no 812 0.195826209514396 971 748350
SGTC_2325 6158266 200 µM 0.85563283130349 0.237702780059863 no 813 0.196100451981993 928 3623240
SGTC_1249 0481-0015 10.2 µM 0.853251487508693 0.238340199201341 no 814 0.196759928211379 943 4227577
SGTC_771 0250-0039 27.3 µM 0.852377302076404 0.238574428888715 no 815 0.197002356943827 933 3005115
SGTC_3293 9120939 62.045 µM 0.852361860419698 0.238578567466153 no 816 0.197006640841874 933 934087
SGTC_883 0850-0245 24.6 µM 0.852090866459051 0.238651203988931 no 817 0.197081830456187 989 6823229 YPR165W RHO1
SGTC_298 1391-0729 10 µM 0.851750954919093 0.238742330109107 no 818 0.197176166397367 955 3237558
SGTC_3307 9126885 69.2785 µM 0.850249352750528 0.239145118966187 no 819 0.197593234172718 956 24824909
SGTC_451 chloral hydrate 100 µM 0.847201223265432 0.239963888257409 no 820 0.198441485907819 1020 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1
SGTC_3068 9116768 49.47 µM 0.846749029166346 0.240085483861289 no 821 0.198567512072625 943 41904888
SGTC_528 3492-0019 172 µM 0.844754574060869 0.240622196111782 no 822 0.199123941043192 1073 2869262
SGTC_2892 9047358 58.44 µM 0.844011980944875 0.240822196291226 no 823 0.199331355328629 914 6466771
SGTC_103 0844-0104 51.839 µM 0.843914573678273 0.240848437380805 no 824 0.19935857187943 1068 5375804
SGTC_2345 9052315 157.45 µM 0.837642035402608 0.242541502706027 no 825 0.201115888518991 956 6469265
SGTC_2715 st079500 56.4 µM 0.83723989406605 0.242650266963023 no 826 0.201228868584349 937 28246688
SGTC_3242 9133940 49.47 µM 0.836449872441745 0.242864015269703 no 827 0.201450932910494 1029 17248444
SGTC_2643 anethole 100 µM 0.836408256302646 0.242875277759444 no 828 0.201462634711101 1024 637563 An anti-fungal, anti-helmenthic and channel blocker.
SGTC_2287 7945887 168.79 µM 0.836232175148962 0.242922933365577 no 829 0.201512150456311 1020 1245853
SGTC_1319 1306-0155 43.7 µM 0.83601124846292 0.24298273337701 no 830 0.201574287517957 1007 3122360
SGTC_1897 st060201 15 µM 0.835084130314305 0.243233770741795 no 831 0.20183517063914 942 611878
SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM 0.833992691868657 0.243529480981304 no 832 0.202142551034087 988 6312947
SGTC_2974 9094440 9.66 µM 0.833990291839637 0.24353013145007 no 833 0.202143227259635 1003 25236134
SGTC_1160 4092-0570 10.5 µM 0.83253850830389 0.243923773549516 no 834 0.202552525778154 977 4994975
SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM 0.831846400635412 0.244111555027811 no 835 0.20274782460947 1055 1377
SGTC_82 0054-0107 293.755 µM 0.828652823563504 0.244979039853238 no 836 0.203650444056091 1012 3104697
SGTC_3000 9075062 71.4286 µM 0.826435156397251 0.24558240852338 no 837 0.204278643668982 947 17057871
SGTC_2945 9067681 61.76 µM 0.826336908830121 0.245609157544189 no 838 0.204306500968065 1015 16456930
SGTC_221 trifluoperazine 10.304 µM 0.824852095592457 0.24601360534916 no 839 0.20472778302316 1102 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1
SGTC_2701 st077767 14.721 µM 0.823808369785862 0.246298119210917 no 840 0.205024225556395 1022 5721188
SGTC_1797 st048695 56.8 µM 0.823806369811675 0.246298664562054 no 841 0.205024793840642 1004 592262 YIL048W NEO1
SGTC_1594 piperine 70.1 µM 0.822148641036267 0.246750915087882 no 842 0.205496152448373 992 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_1557 sumaresinolic acid 42.3 µM 0.82146882686988 0.246936505934623 no 843 0.205689636703255 972 9982268 A natural terpine and antifungal of unknown mechanisn.
SGTC_2261 9010538 184.68 µM 0.821073374280424 0.247044499766529 no 844 0.205802237552681 899 6457250
SGTC_583 1488-1091 88.9 µM 0.81875619334588 0.247677804334014 no 845 0.206462764471604 1157 4303273
SGTC_3047 9092122 49.47 µM 0.818355145415417 0.247787501976257 no 846 0.206577213060874 1005 17173831
SGTC_1543 azetidyl-2-carboxylic acid 198 µM 0.818186888679795 0.24783353254551 no 847 0.206625240319553 1073 16486 A toxic proline analog.
SGTC_1776 st049249 45.9 µM 0.817441194915751 0.248037589465438 no 848 0.206838170978446 1059 1822314
SGTC_2446 5162541 200 µM 0.816450018359911 0.248308960734463 no 849 0.207121399500103 955 1549321
SGTC_1431 4049-0260 9.09 µM 0.814400020760672 0.248870725310362 no 850 0.207707913376736 1020 3854841
SGTC_1905 st060207 84.5 µM 0.814296771498809 0.248899036777146 no 851 0.207737479401625 989 1948547
SGTC_2480 5767542 37.17 µM 0.813545249705767 0.249105159470266 no 852 0.207952756916199 1046 2867358
SGTC_2245 6637752 200 µM 0.813365927060286 0.249154356377983 no 853 0.208004144323137 966 681890
SGTC_2803 7707263 71.43 µM 0.813001063436406 0.249254472136484 no 854 0.208108724227785 974 2199229
SGTC_1133 3473-0247 50 µM 0.812896183931727 0.249283254219624 no 855 0.208138791306746 942 711311
SGTC_2145 5634607 200 µM 0.810524479574952 0.249934592594831 no 856 0.208819400771911 973 308662
SGTC_448 monastrol 171 µM 0.810273277287289 0.250003632843758 no 857 0.208891565170959 1043 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity
SGTC_869 0564-0080 44.1 µM 0.808865072312583 0.250390850145202 no 858 0.209296380675381 977 6843321
SGTC_1591 genipin 88.4 µM 0.808568135303498 0.250472540149259 no 859 0.209381799817184 975 442424 A DNA cross-linking agent.
SGTC_912 3474-0017 2.18 µM 0.806464505790282 0.251051671496735 no 860 0.209987532983898 1034 3360550
SGTC_654 1124-0271 80.9 µM 0.80641616112019 0.251064989156386 no 861 0.210001465765344 1018 5403748
SGTC_2932 9016711 44.54 µM 0.805740268527552 0.251251218566816 no 862 0.210196312757064 1062 7117328
SGTC_627 1391-0720 175 µM 0.805724412616405 0.251255588239715 no 863 0.210200884989292 998 997839
SGTC_2979 9012552 45.46 µM 0.805607775116626 0.25128773317916 no 864 0.210234520533524 999 17100905
SGTC_2587 piperic acid 92.2 µM 0.805547737571 0.251304280191387 no 865 0.21025183519857 967 5370536
SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM 0.805249233100077 0.251386559879932 no 866 0.210337935508931 958 6857784
SGTC_2772 vinpocetine 57.06 µM 0.804365456568365 0.251630247258838 no 867 0.21059297241457 1000 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor.
SGTC_892 0929-0076 29 µM 0.802551648457527 0.252130766677529 no 868 0.21111696232967 1054 5751038
SGTC_2656 pseudo-anisatin 100 µM 0.801395435767218 0.252450096834079 no 869 0.211451378316061 1049 6708809 A neurotoxin.
SGTC_1122 capsaicin 818.572 nM 0.801038852177045 0.252548623337987 no 870 0.211554576958253 1035 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_3227 9130768 49.47 µM 0.798540241655173 0.253239574579996 no 871 0.212278525111642 1060 17720899
SGTC_1080 nisoldipine 24.4 µM 0.798396199640373 0.253279437403645 no 872 0.212320303983059 1064 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class.
SGTC_3296 9122258 64.045 µM 0.793709723159646 0.254578191301638 no 873 0.213682219244584 1036 4730474
SGTC_3135 9127742 49.47 µM 0.790148239100377 0.255567506157981 no 874 0.214720600320722 973 3643468
SGTC_2455 5377712 9.75 µM 0.789671950886581 0.25569996235009 no 875 0.214859688156596 973 2243908
SGTC_1933 st074711 15.9 µM 0.788469025212034 0.256034656613844 no 876 0.215211204869372 1098 17250958
SGTC_177 1327-0068 8.361 µM 0.788398437298494 0.256054303634746 no 877 0.215231842301613 1041 15389900 YOR207C | YLR033W RET1 | RSC58
SGTC_2077 5212015 200 µM 0.788341877527342 0.256070046713246 no 878 0.21524837922546 1014 780900
SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM 0.786128923536248 0.256686405485548 no 879 0.215895980474696 1073 5355888
SGTC_1149 3909-7961 23.3 µM 0.784877570024322 0.257035277911001 no 880 0.21626267708105 1038 735261
SGTC_3255 9139072 49.47 µM 0.784733364677974 0.257075497635947 no 881 0.216304958171667 1095 17646060
SGTC_1269 0831-0796 3.05 µM 0.784717216786744 0.257080001582195 no 882 0.216309693040586 1075 927758
SGTC_2018 5133068 143 µM 0.7843507006363 0.257182240767615 no 883 0.216417178683624 1013 785362
SGTC_2457 5731572 11.68 µM 0.784056917053981 0.257264206562465 no 884 0.216503356865937 1099 2865357
SGTC_213 1246-0773 967 nM 0.783431112028505 0.257438851797544 no 885 0.216686996069426 1054 6251622
SGTC_1074 carmofur 3.8 µM 0.78296779128482 0.257568191741718 no 886 0.216823013132002 1125 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_2310 7668677 200 µM 0.78257633352106 0.257677496817526 no 887 0.216937971844251 1062 2197143
SGTC_1808 st050063 61.5 µM 0.779730582812044 0.258472826901756 no 888 0.217774736750187 1060 4011993
SGTC_833 3852-0053 558 µM 0.778149406137363 0.258915282877865 no 889 0.218240469628837 1108 3123681
SGTC_2112 5488546 200 µM 0.777662827655757 0.259051519487427 no 890 0.218383905881901 1071 600757
SGTC_1900 st060200 72.8 µM 0.77662101184997 0.259343341030133 no 891 0.218691200545633 1071 688945
SGTC_1241 0364-0022 50.8 µM 0.775731326526771 0.259592683909635 no 892 0.218953819611026 1054 4563895
SGTC_2533 agelasine 13.65 µM 0.774803734773602 0.259852782162401 no 893 0.219227821032789 1109 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase.
SGTC_2293 7624732 200 µM 0.774786511238689 0.259857612940986 no 894 0.219232910557672 1077 894453
SGTC_1429 4049-0205 9.46 µM 0.77429747354912 0.259994795334692 no 895 0.219377448691564 1128 22774478
SGTC_1127 asiatic acid 681.4 nM 0.774005104905263 0.260076826950867 no 896 0.219463886211584 1022 470603 A kinase inhibitor which arrests cells at G2/M.
SGTC_150 3970-0969 77.2 µM 0.773431223629468 0.260237883040595 no 897 0.219633608601331 1072 6615640
SGTC_3336 9143619 71.43 µM 0.773280175487858 0.26028028227279 no 898 0.219678292827267 1106 45595730
SGTC_254 nsc-64875 3.808 µM 0.770469119030812 0.26106999516662 no 899 0.220510833230593 1102 56993
SGTC_1029 k015-0030 64.7 µM 0.769208232529909 0.261424616995852 no 900 0.22088485199604 1046 2208316
SGTC_1342 1486-1464 234 µM 0.769006892901014 0.261481266262176 no 901 0.220944609299842 1123 3253938
SGTC_2242 6630449 61.2675 µM 0.766977929558664 0.262052490479354 no 902 0.221547318905089 991 691249 YDR170C SEC7
SGTC_1826 st055655 41.6 µM 0.766618230566888 0.262153825047267 no 903 0.221654266544621 1060 676168
SGTC_2337 9009472 200 µM 0.7629541093017 0.263187225842039 no 904 0.2227453823359 1095 5742383
SGTC_1528 arabinosylhypoxanthine 74.6 µM 0.761651131818088 0.263555208611547 no 905 0.223134124416198 1100 804 An inhibitor of viral and cellular DNA polymerases.
SGTC_1829 berberine 14.4 µM 0.759061393601649 0.26428737295587 no 906 0.223907916026991 1093 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_161 4065-0411 162.148 µM 0.755593294198456 0.265269484904225 no 907 0.224946538844473 1087 1906281 YLR208W SEC13
SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM 0.754424620583357 0.265600852025845 no 908 0.225297146182388 1016 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding.
SGTC_1436 4092-1007 8.32 µM 0.751871934790012 0.266325372969953 no 909 0.226064038595174 1089 2881121
SGTC_3080 9117754 49.47 µM 0.748950192782295 0.267155867756288 no 910 0.226943613057026 1147 9550191
SGTC_2833 9001315 45.46 µM 0.747200581401631 0.267653813630742 no 911 0.227471246598395 1086 2989378
SGTC_2053 5265679 138 µM 0.747061804948135 0.267693329937569 no 912 0.227513127224959 1116 764595
SGTC_1426 4048-4480 71.7 µM 0.746904732352314 0.267738059579862 no 913 0.227560534588081 1115 14224343
SGTC_2597 laccaic acid a 100 µM 0.746852789748842 0.267752852129833 no 914 0.227576213033322 1080 5491415 A textile dye.
SGTC_1494 4358-1428 177 µM 0.746601472497225 0.267824429695269 no 915 0.227652079657469 1161 1564571
SGTC_781 4335-2806 94.4 µM 0.744622013048585 0.268388535490851 no 916 0.228250128268201 1185 845254
SGTC_3322 9139058 2.11 µM 0.744357348387055 0.268464004813088 no 917 0.228330157552354 1105 4908926 YPR165W RHO1
SGTC_967 1306-0166 352 µM 0.741424766248378 0.269300946210073 no 918 0.229217966290315 1105 4437607
SGTC_1233 0325-0408 14.2 µM 0.740626844306937 0.26952889459424 no 919 0.229459863433516 1106 12874
SGTC_1479 0549-0158 134 µM 0.739664941827296 0.269803817017907 no 920 0.229751662825048 1194 5440202
SGTC_609 0986-0026 86.3 µM 0.73870217242605 0.270079127748518 no 921 0.230043933168623 1106 2848610
SGTC_3091 9116372 49.47 µM 0.73780654691882 0.270335364331163 no 922 0.230316007162802 1120 17169793
SGTC_1523 st012844 44.7 µM 0.73753003818112 0.27041449744626 no 923 0.230400041595841 1116 4274103
SGTC_2511 berberine 10.47 µM 0.736410024019554 0.270735148939687 no 924 0.230740603065868 1120 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_2659 sanguinarine 24.21 µM 0.735139640131854 0.271099079766986 no 925 0.231127227412761 1106 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis.
SGTC_823 0417-1665 178 µM 0.734355931002308 0.271323712977195 no 926 0.231365918989367 1156 3429856
SGTC_2702 st077768 96.8 µM 0.733314707073925 0.271622300633688 no 927 0.231683253502069 1062 6484119
SGTC_2216 7189485 200 µM 0.732727950831152 0.271790634440373 no 928 0.231862186388619 1145 731273
SGTC_1770 st043884 66.3 µM 0.731696657340958 0.272086626770663 no 929 0.232176868552593 1154 670149
SGTC_3221 9128209 49.47 µM 0.730652469997677 0.272386482970814 no 930 0.232495727082437 1130 16460723
SGTC_209 4077-0173 175.592 µM 0.728170589861291 0.273099855261064 no 931 0.233254583379954 1076 15993494
SGTC_1325 1431-0015 227 µM 0.726983728530936 0.273441324407977 no 932 0.233617961789576 1098 1103340
SGTC_1732 st034308 51.822 µM 0.724216861050045 0.274238193353773 no 933 0.234466304342202 1058 830119
SGTC_1229 0139-0193 12.2 µM 0.724077124682551 0.274278468390285 no 934 0.234509193737127 1185 3090752
SGTC_77 0828-0286 12.516 µM 0.72066772451519 0.275262035066143 no 935 0.235556987365598 1150 745345
SGTC_2735 sertaconazole 140 nM 0.719488736289715 0.275602561057083 no 936 0.235919919922582 1191 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C
SGTC_2718 lomofungin 53.02 µM 0.718412021963785 0.275913728237912 no 937 0.236251638188418 1174 5351222 A RNA synthesis inhibitor.
SGTC_1927 st060202 13.8 µM 0.717609135746966 0.276145872193216 no 938 0.236499161524411 1141 688887
SGTC_2845 9003024 42.97 µM 0.714721845370389 0.276981485566592 no 939 0.237390468188567 1191 2990173
SGTC_2037 5169046 200 µM 0.714613420917834 0.277012888886509 no 940 0.237423974713509 1153 5718022
SGTC_2510 benzyl isothiocyanate 8.31 µM 0.713773596717117 0.277256188861697 no 941 0.237683594409751 1146 2346 DNA damaging agent; causes G2/M arrest.
SGTC_412 gemfibrozil 100 µM 0.713699687895616 0.27727760550575 no 942 0.237706449723991 1162 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels.
SGTC_721 1187-1332 279 µM 0.71123147575875 0.277993286488667 no 943 0.238470403340132 1103 25730
SGTC_696 1560-0013 611 µM 0.711029972419442 0.27805175402381 no 944 0.238532831344715 1212 1650269
SGTC_2751 anetholtrithion 17.25 µM 0.709149594815049 0.278597647120902 no 945 0.239115824550508 1144 2194 A chloretic substance that stimulates the liver to produce bile.
SGTC_950 1165-0508 94.1 µM 0.708883281397881 0.278675002840151 no 946 0.239198455407805 1153 6148369
SGTC_2153 5569715 200 µM 0.708853704559718 0.278683594631852 no 947 0.239207633375142 1167 2054701
SGTC_637 1181-0519 7.26 µM 0.705470091895911 0.279667352495221 no 948 0.24025886896786 1200 6252091 YGR060W ERG25
SGTC_1145 3546-0597 10.2 µM 0.70404879094093 0.280081086264315 no 949 0.240701194622478 1151 875334
SGTC_810 3825-7150 143 µM 0.702975942665069 0.280393583507906 no 950 0.241035371006106 1230 22330411 YGL099W LSG1
SGTC_1681 tripelennamine 100 µM 0.702741882954362 0.280461782409547 no 951 0.241108310656824 1184 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist.
SGTC_2492 derrusnin 100 µM 0.701006176449288 0.280967772464879 no 952 0.241649580339215 1125 1715307 Part of coumarin class of compounds.
SGTC_2343 7990716 14.84 µM 0.700654514051504 0.281070342178265 no 953 0.241759324461598 1176 6456862
SGTC_3282 9108498 15.4605 µM 0.700140809925998 0.281220207265147 no 954 0.241919685936815 1163 16459645
SGTC_231 b-estradiol 524 µM 0.699301890246758 0.281465031793599 no 955 0.242181692993133 1148 450 A steroid.
SGTC_2903 5923464 63.88 µM 0.698961340077806 0.28156444494153 no 956 0.242288095741859 1225 2876576
SGTC_640 3381-0960 37.1 µM 0.697892301870711 0.281876627746989 no 957 0.242622274509294 1223 1745025
SGTC_2124 5246320 200 µM 0.695185960030367 0.282667684124868 no 958 0.243469384933203 1180 579342
SGTC_233 rapamycin 362 pM 0.694667937300755 0.28281922232678 no 959 0.243631712912135 1217 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C
SGTC_1369 1866-0067 208 µM 0.69309297210544 0.283280189497999 no 960 0.244125603901382 1226 3531355
SGTC_2835 9006588 71.43 µM 0.692820737967362 0.283359904595207 no 961 0.244211028095272 1192 2345538
SGTC_370 0180-0345 38.7 µM 0.69198933286367 0.28360342166081 no 962 0.244472013960787 1142 3989527
SGTC_2882 9058044 58.44 µM 0.688120917131325 0.284737790296212 no 963 0.245688319665863 1167 18076804
SGTC_2760 etidronate 98.04 µM 0.68651202603776 0.285210215985932 no 964 0.246195141688981 1215 3305 A chelator and antioxidant.
SGTC_187 1488-2104 32.728 µM 0.686384263201257 0.285247747545797 no 965 0.246235412690485 1239 2852859
SGTC_1064 honokiol 6.76 µM 0.685319014353012 0.285560766190824 no 966 0.246571317870473 1213 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis.
SGTC_257 daunorubicin 18.5 µM 0.6849734687132 0.285662338349672 no 967 0.2466803315648 1248 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_1032 k061-1018 98.7 µM 0.683324392179247 0.286147316335737 no 968 0.247200942116568 1288 4005393
SGTC_2966 9084041 48.03 µM 0.682194645067384 0.286479789991409 no 969 0.247557940141771 1147 17741380
SGTC_2006 4011487 200 µM 0.680554983551479 0.286962652335492 no 970 0.248076559756458 1241 45595294
SGTC_1112 tnp00069 1.16933 µM 0.680462301110087 0.286989957807051 no 971 0.248105892209101 1251 145826
SGTC_1049 3226-0134 66 µM 0.677480548939651 0.287869077385183 no 972 0.249050553605398 1260 5702385
SGTC_3218 9131285 49.47 µM 0.677329230123047 0.287913725085622 no 973 0.249098544521895 1243 17156417
SGTC_2774 tamoxifen 10.92 µM 0.67724497143339 0.287938587632577 no 974 0.249125269383099 1261 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.
SGTC_2333 9017922 200 µM 0.67634537559658 0.288204098123086 no 975 0.249410694922485 1249 3163164
SGTC_840 0245-0196 390 µM 0.674796735400215 0.288661440634927 no 976 0.249902457394353 1283 3827528
SGTC_400 oxethazaine 37.5 µM 0.674518893479989 0.288743528717861 no 977 0.249990739038145 1208 4621 A local anesthetic.
SGTC_2144 5628481 200 µM 0.674490759476595 0.28875184149034 no 978 0.249999679274407 1216 2818399
SGTC_793 0488-0545 106 µM 0.67383721355476 0.288944976837569 no 979 0.250207406482197 1217 292548
SGTC_472 calcifediol 10 µM 0.670539465163151 0.28992045066736 no 980 0.251256978592004 1228 5283731 A vitamin D metabolite.
SGTC_573 3702-0553 84.7 µM 0.669803976781202 0.290138218542753 no 981 0.251491379077839 1217 1222756
SGTC_2106 5357045 167.29 µM 0.669731815128352 0.29015958873253 no 982 0.251514383253048 1248 668842
SGTC_50 0929-0078 56.389 µM 0.669085762494143 0.290350945741206 no 983 0.251720385766821 1156 1377751
SGTC_1517 deoxycholic acid methyl ester 49.2 µM 0.668832059864393 0.290426107131059 no 984 0.251801306598095 1256 229346 A bile salt which induces apoptosis.
SGTC_3147 9097027 49.47 µM 0.666305219003247 0.291175200163442 no 985 0.252608015192072 1264 25236841
SGTC_38 0929-0051 58.268 µM 0.661298999892756 0.292661973928147 no 986 0.25421029136126 1249 1379719
SGTC_2305 7443522 69.23 µM 0.661271528638456 0.292670142208324 no 987 0.254219098411165 1226 5415886
SGTC_1308 1187-1617 41.4 µM 0.659161496479802 0.293297853624131 no 988 0.254896034529025 1255 2882570
SGTC_2867 9039098 71.43 µM 0.658763064069804 0.293416452895093 no 989 0.255023964586992 1239 6463460
SGTC_578 3460-0051 92 µM 0.658431196074618 0.293515255245163 no 990 0.255130547548086 1312 2876744
SGTC_2259 7964009 200 µM 0.658419633733629 0.293518697814656 no 991 0.25513426133766 1271 313134
SGTC_2219 9098279 200 µM 0.656015433040205 0.294234929953942 no 992 0.255907097180399 1248 902349
SGTC_1635 st007035 42.4 µM 0.655887799619693 0.294272975609386 no 993 0.255948159358533 1279 3716403
SGTC_2427 5545055 42.75 µM 0.650080930930119 0.296006316243873 no 994 0.257819973039919 1290 5372858
SGTC_1341 1486-1360 280 µM 0.648979603428455 0.296335588684937 no 995 0.258175779952901 1256 3976547
SGTC_1716 st033144 30.6155 µM 0.648543156581408 0.296466123038399 no 996 0.258316853645327 1289 674617
SGTC_961 1252-1571 372 µM 0.647116406814348 0.29689302510441 no 997 0.258778303758376 1292 6813498
SGTC_147 4466-0538 29.23 µM 0.646212275792208 0.297163698376916 no 998 0.259070945269299 1334 6742687 YHR072W ERG7
SGTC_1942 st076330 65.2 µM 0.644066831460752 0.297806439526293 no 999 0.259766048793701 1312 24208414
SGTC_2102 5377816 72.7585 µM 0.643197072408796 0.298067186069245 no 1000 0.260048116356059 1297 1379702
SGTC_724 3910-0327 137 µM 0.642814630430158 0.298181871917358 no 1001 0.260172194325357 1261 2885483
SGTC_481 bay k-8644 50 µM 0.642235738800782 0.298355506874418 no 1002 0.260360065679779 1225 2303 A calcium channel antagonist.
SGTC_180 1486-1293 102.781 µM 0.640638202081617 0.298834916698223 no 1003 0.260878886655091 1331 4140536
SGTC_903 1134-0042 114 µM 0.639208407089586 0.299264284974183 no 1004 0.261343681841575 1277 701009
SGTC_2002 4023503 131 µM 0.636855572136471 0.299971451237117 no 1005 0.262109462026144 1336 4736863 YCR052W RSC6
SGTC_1860 st056228 74.6 µM 0.636291543501475 0.300141087548384 no 1006 0.26229320787253 1259 688679
SGTC_708 3448-5400 146 µM 0.635992163719033 0.30023114613367 no 1007 0.262390764809687 1270 3462195
SGTC_25 0118-0223 35.662 µM 0.634863378023321 0.300570814087218 no 1008 0.262758761865447 1323 5333628
SGTC_84 0443-0269 128.823 µM 0.634523734152229 0.300673051792812 no 1009 0.262869541299024 1247 6150058
SGTC_488 nitrendipine 139 µM 0.634509423245321 0.300677359926862 no 1010 0.262874209518778 1322 4507 Dihydropyridine L-type calcium channel blocker.
SGTC_915 methyl methanesulfonate (MMS) 110 mM 0.634115275938845 0.300796024392349 no 1011 0.263002797082014 1328 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks.
SGTC_2661 dactinomycin 12.96 µM 0.633735016994695 0.300910527560494 no 1012 0.263126884136322 1296 45006140 An Actinomycin D Classic transcription inhibitor.
SGTC_323 4013-0906 34.3 µM 0.631499287805657 0.301584145099265 no 1013 0.263857057378497 1321 2910086
SGTC_1440 4100-1550 40 µM 0.631333745560895 0.301634049372454 no 1014 0.263911163345466 1299 742806
SGTC_2870 9038528 12.99 µM 0.631275020174651 0.301651753587205 no 1015 0.263930358559184 1280 6463316
SGTC_1802 st050112 57.9 µM 0.628656256155204 0.302441719101068 no 1016 0.264787061026475 1283 4662563
SGTC_405 ebelactone b 50 µM 0.6282710732538 0.302557989996563 no 1017 0.264913188925556 1299 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).
SGTC_3005 9076496 71.4286 µM 0.627339461281583 0.302839288175137 no 1018 0.265218370860643 1311 21368410
SGTC_2160 5660466 132.927 µM 0.626886270867808 0.302976170344792 no 1019 0.265366893672974 1247 2859134
SGTC_713 1488-1073 324 µM 0.623973240204192 0.303856685733602 no 1020 0.266322579613848 1273 3312542
SGTC_2373 9071805 200 µM 0.623932750411646 0.303868932533979 no 1021 0.266335875473774 1333 10149009
SGTC_2051 5263410 176 µM 0.621456372380101 0.304618371667854 no 1022 0.267149695588612 1349 227584
SGTC_2284 7945075 39.21 µM 0.619648974205584 0.305165872366655 no 1023 0.267744458103004 1361 1245402
SGTC_1317 1273-0028 910 nM 0.619579539326234 0.305186914430084 no 1024 0.267767320417017 1293 5917803 YLR359W | YHR072W ADE13 | ERG7
SGTC_2884 9058502 51.95 µM 0.618835798233664 0.305412343651912 no 1025 0.268012268275275 1308 6471554
SGTC_2465 5809242 33.21 µM 0.61631610545783 0.306176615129699 no 1026 0.268842955661092 1312 2731748
SGTC_2796 7949634 45.45 µM 0.615044297163307 0.306562700011229 no 1027 0.26926273340519 1293 2971588
SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM 0.614893391829163 0.306608524847521 no 1028 0.269312563585978 1326 6708784 An antioxidant flavonoid
SGTC_2011 4012611 177 µM 0.614853543126276 0.306620626052889 no 1029 0.269325722726726 1310 2049887
SGTC_430 0958-0115 16.4 µM 0.614443775594014 0.30674507598431 no 1030 0.269461057969449 1319 6833180
SGTC_2822 7994718 71.43 µM 0.614323843131166 0.306781504722481 no 1031 0.269500674897723 1312 1018011
SGTC_2063 5246145 200 µM 0.613553186454484 0.307015632402795 no 1032 0.269755313216261 1356 711240
SGTC_2258 7960471 200 µM 0.613409120309356 0.307059408841326 no 1033 0.269802928530574 1267 2974708
SGTC_1792 st045773 43.6 µM 0.612780949369826 0.307250319177718 no 1034 0.270010594530979 1287 2919270
SGTC_1239 0337-0584 35.4 µM 0.611164179273159 0.30774191945763 no 1035 0.270545447486416 1385 914301 YML130C ERO1
SGTC_2532 xanthone 78.9 µM 0.610794709126642 0.307854310242067 no 1036 0.270667748271923 1303 7020 An insecticide.
SGTC_935 2996-0153 430 µM 0.607610969159438 0.30882353256341 no 1037 0.271722761966665 1335 23738523
SGTC_899 1083-0020 478 µM 0.607533836216036 0.308847030621132 no 1038 0.271748347314186 1385 767123
SGTC_3 0833-0587 95.581 µM 0.607050365678316 0.308994334647361 no 1039 0.271908743993121 1258 5382644
SGTC_112 phenothiazine 287.218 µM 0.604165930042142 0.309873803581936 no 1040 0.2728666648605 1343 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.
SGTC_3346 9158254 43.5805 µM 0.60405457676889 0.309907777236006 no 1041 0.272903678802655 1313 17639500
SGTC_1922 5578187 25 µM 0.603582736321321 0.310051752794093 no 1042 0.273060546674361 1414 1350412
SGTC_2633 5,7-dihydroxyisoflavone 100 µM 0.603527161668921 0.310068712545158 no 1043 0.273079025941043 1382 5377381
SGTC_129 0088-0017 176.636 µM 0.602754083909785 0.310304675056373 no 1044 0.273336148224543 1275 182446
SGTC_1588 farnesol 29.9 µM 0.602461525235057 0.310393991599601 no 1045 0.273433483223437 1344 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_2253 7938677 135.83 µM 0.602403590858435 0.310411679970529 no 1046 0.273452760170044 1431 2301972
SGTC_1920 st075728 45.7 µM 0.602216436584476 0.310468824415355 no 1047 0.273515038034733 1412 3400306
SGTC_2118 5526350 200 µM 0.601413406620551 0.310714068170306 no 1048 0.273782335697153 1375 743594
SGTC_3123 9126162 49.47 µM 0.600606228455457 0.310960663563186 no 1049 0.274051144260965 1388 25239884
SGTC_2733 amorolfine 100 µM 0.600510012902705 0.310990063374046 no 1050 0.274083194910645 1380 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_2501 sodium tetradecyl sulfate 13.37 µM 0.600283567231762 0.311059261312664 no 1051 0.274158634211101 1343 23665772 A membrane-active detergent.
SGTC_2227 7312221 64.1025 µM 0.599738579269827 0.311225827728441 no 1052 0.274340236400289 1343 887188 YOR168W | YOR169C GLN4 | YOR169C
SGTC_2276 7947513 42.08 µM 0.598342016129771 0.311652840213723 no 1053 0.274805873406053 1199 2105100
SGTC_306 1672-3436 11.6 µM 0.596750409255922 0.312139798137217 no 1054 0.275337015752729 1371 6797378
SGTC_2044 5102272 200 µM 0.594299962676757 0.312890163074486 no 1055 0.276155751800498 1336 592666
SGTC_904 1141-0088 396 µM 0.593312686755219 0.313192701798783 no 1056 0.276485954933948 1269 1378119
SGTC_992 3909-8734 162 µM 0.59142861136433 0.313770402788513 no 1057 0.277116637296617 1343 4288319
SGTC_3134 9127454 49.47 µM 0.591272308856019 0.313818349287139 no 1058 0.277168990182796 1424 24262820
SGTC_2330 7979373 200 µM 0.590943720228584 0.313919155581174 no 1059 0.277279065377151 1293 1863007
SGTC_1686 st019653 115.5 µM 0.587290145842302 0.315040954385832 no 1060 0.278504429074298 1393 97252
SGTC_765 1319-0117 244 µM 0.587179938523253 0.315074819191883 no 1061 0.278541432196008 1318 3487746 YGL099W LSG1
SGTC_2665 lovastatin 100 µM 0.586679849757651 0.315228507360364 no 1062 0.27870937168392 1332 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1
SGTC_2146 5545642 200 µM 0.584938130703732 0.315764025097644 no 1063 0.279294659174715 1370 825326
SGTC_31 0508-1974 57.237 µM 0.584709173213474 0.315834450327202 no 1064 0.279371642471055 1332 6810525
SGTC_2177 5811945 192 µM 0.582610614321517 0.316480259064128 no 1065 0.280077729186405 1422 5343475
SGTC_1084 voriconazole 435 nM 0.573383447951942 0.319326442239014 no 1066 0.283192547485522 1396 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_1813 st051246 8.6015 µM 0.570678440619344 0.320162852395634 no 1067 0.284108817835571 1364 5291959
SGTC_1640 st009078 66.4 µM 0.568969764390899 0.320691660602085 no 1068 0.284688329531306 1434 690618
SGTC_32 0928-0142 34.1 µM 0.568071864459024 0.320969692406315 no 1069 0.28499308573155 1348 2244242
SGTC_179 1273-0063 6.77 µM 0.567782638136081 0.321059271789736 no 1070 0.285091285149588 1346 3108139
SGTC_1645 Cervolide 78 µM 0.567573736497013 0.321123979432945 no 1071 0.285162222402047 1337 23173 A fragrance.
SGTC_1383 3049-0032 20.7 µM 0.565024914238567 0.321913918466641 no 1072 0.286028409117421 1459 712864
SGTC_1442 4112-3290 3 µM 0.561527052529394 0.322999297557522 no 1073 0.287219146832375 1372 704353
SGTC_3140 9094243 49.47 µM 0.560407371332687 0.32334705154758 no 1074 0.28760080242141 1389 19291112
SGTC_568 1193-0097 7.48 µM 0.559725067954127 0.32355903913359 no 1075 0.287833490482696 1325 3646150
SGTC_3159 9100096 49.47 µM 0.55954929078423 0.323613661331774 no 1076 0.287893450723686 1336 25236875
SGTC_2174 5790901 200 µM 0.55932498444804 0.323683369333518 no 1077 0.2879699735592 1394 786020
SGTC_928 2764-0428 58.7 µM 0.559003823264751 0.323783187824718 no 1078 0.288079555454752 1458 662578
SGTC_2704 st078022 71.1 µM 0.555892325695501 0.324750912146589 no 1079 0.289142232410673 1485 54697681
SGTC_1851 st056236 18.9 µM 0.555033959277227 0.325018086161292 no 1080 0.289435716334421 1438 5393171
SGTC_2244 6635614 200 µM 0.553861434592202 0.325383190104754 no 1081 0.289836840033494 1393 836499
SGTC_124 0136-0217 7.121 µM 0.553083182301515 0.325625617023498 no 1082 0.290103226038594 1514 3976905
SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM 0.553053037428355 0.32563500868774 no 1083 0.290113546558776 1508 16725076
SGTC_85 0868-0259 160.055 µM 0.552906534560204 0.325680653373281 no 1084 0.290163706320721 1431 83173
SGTC_2722 naftopidil 47.16 µM 0.551148500018236 0.326228593337199 no 1085 0.290765940224203 1437 4418 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_1940 st075990 51.1 µM 0.550653669631443 0.326382888616138 no 1086 0.290935555113126 1492 1084979
SGTC_911 3456-4043 236 µM 0.550390759981543 0.326464879741029 no 1087 0.291025692456711 1499 914281
SGTC_1232 0279-0259 161 µM 0.548739632574774 0.326979992645611 no 1088 0.291592071785214 1415 1560000
SGTC_3053 9095903 49.47 µM 0.548127914236118 0.327170918165255 no 1089 0.291802037362503 1459 17174018
SGTC_1783 st039459 87.517 µM 0.547919886801953 0.327235856634342 no 1090 0.291873456533437 1537 729761
SGTC_3214 9129694 49.47 µM 0.545402626546555 0.328022066187199 no 1091 0.292738317192124 1478 17158655
SGTC_1719 st032227 49.2 µM 0.545206090328008 0.328083481989484 no 1092 0.292805891630204 1399 3125804
SGTC_2931 9014674 55.67 µM 0.543942435392236 0.328478473763805 no 1093 0.293240543060278 1384 2996810
SGTC_2228 7354201 200 µM 0.541999588397125 0.329086140562393 no 1094 0.29390939471623 1475 753451
SGTC_383 2324-0395 7.37 µM 0.540111668712702 0.329677060664009 no 1095 0.294560011994376 1485 3146421
SGTC_188 3229-0966 278.469 µM 0.540070614907074 0.329689915263717 no 1096 0.294574167388828 1530 5722370
SGTC_1558 st069300 45.6 µM 0.534550893994742 0.331420054410893 no 1097 0.296480223873628 1466 24208000
SGTC_1230 0170-0365 3.77 µM 0.533905379162982 0.331622625073199 no 1098 0.296703500122866 1489 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1
SGTC_2340 7987427 183.45 µM 0.533176613721949 0.331851380012262 no 1099 0.296955664301867 1470 2239331
SGTC_544 k015-0020 52.4 µM 0.532751823244113 0.331984748033066 no 1100 0.29710269363123 1439 3008304
SGTC_2572 astragaloside iv 100 µM 0.532069409876319 0.332199044389763 no 1101 0.297338961572636 1453 45006101 An anti-inflammatory agent.
SGTC_2857 9024691 58.44 µM 0.531361765996746 0.332421321777341 no 1102 0.297584055543315 1462 16478292
SGTC_1011 4112-3381 17.4 µM 0.531019919493861 0.332528719998327 no 1103 0.297702487835336 1472 2877139
SGTC_2356 9061756 188.97 µM 0.5284362643126 0.333340873357846 no 1104 0.298598286562828 1454 20104043
SGTC_2190 6049624 200 µM 0.528430261661182 0.333342761159892 no 1105 0.298600369214418 1439 2265554
SGTC_1487 3970-0795 2.82 µM 0.528250986187838 0.333399144291341 no 1106 0.298662572830752 1472 3765103
SGTC_106 0092-0003 11.579 µM 0.527681633184253 0.333578233927126 no 1107 0.298860161586518 1503 1072148
SGTC_140 0062-0056 502.533 µM 0.52679667500127 0.333856672263937 no 1108 0.299167396078468 1357 3758964
SGTC_2204 7233102 200 µM 0.526029632070165 0.334098084435112 no 1109 0.299433809366528 1444 2172480
SGTC_1762 st045503 25.4615 µM 0.525440295756314 0.334283613475687 no 1110 0.29963857372398 1439 4645554
SGTC_2403 6032726 181.2 µM 0.525143505548435 0.334377061372114 no 1111 0.299741717220846 1454 2881040
SGTC_1142 3253-1408 9.78 µM 0.524198493515838 0.334674677902589 no 1112 0.300070244301317 1443 256655
SGTC_482 fipronil 114 µM 0.523307028820958 0.334955525790308 no 1113 0.300380305223065 1470 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels.
SGTC_2591 skatole 100 µM 0.523165766900735 0.335000037557916 no 1114 0.300429450908523 1455 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite.
SGTC_1335 1486-0900 202 µM 0.522525225311672 0.335201901905571 no 1115 0.300652343900433 1422 X1335
SGTC_1017 4239-0030 168 µM 0.521443428993527 0.335542934134843 no 1116 0.3010289522581 1400 1149593
SGTC_2513 baicalein 25.65 µM 0.519786591190241 0.336065508701434 no 1117 0.301606163045504 1389 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2
SGTC_1649 st011737 51.3 µM 0.519537594214257 0.336144070963505 no 1118 0.301692951870697 1424 1761035
SGTC_742 0kpi-0133 140 µM 0.518025939962815 0.336621173960169 no 1119 0.30222008545506 1527 2728852
SGTC_1276 0871-0068 94.2 µM 0.517886696047051 0.336665134880599 no 1120 0.302268662411808 1510 3414906
SGTC_2383 9036125 200 µM 0.516907549933372 0.336974325678684 no 1121 0.302610348493372 1472 79580
SGTC_1777 st045864 34.765 µM 0.515914363810283 0.337288062545416 no 1122 0.302957110741107 1459 4691462
SGTC_163 TUB2.036 7.546 µM 0.513891030142416 0.337927561949568 no 1123 0.303664089561536 1474 15992207 YJR013W GPI14
SGTC_1671 st016596 74.5 µM 0.511436935617573 0.338703836670788 no 1124 0.304522568584353 1458 2829167
SGTC_3033 9090887 49.47 µM 0.51018601790253 0.339099788739281 no 1125 0.304960573428132 1422 19325384
SGTC_9 0092-0002 10.449 µM 0.509220920754236 0.339405391752953 no 1126 0.305298690226409 1472 759368
SGTC_621 3584-0052 32.1 µM 0.507883094417087 0.339829196096347 no 1127 0.305767665609364 1513 2273927
SGTC_602 3130-1533 38.1 µM 0.50764076751929 0.339905983489597 no 1128 0.305852647485147 1541 720941
SGTC_534 k292-0788 63.4 µM 0.507445027699667 0.339968013441474 no 1129 0.305921299322481 1524 4146317
SGTC_1653 st012112 65 µM 0.506972709812756 0.340117708825265 no 1130 0.306086983476568 1494 720429
SGTC_2180 6301957 200 µM 0.503826090671666 0.341115633654748 no 1131 0.307191795792433 1457 845462
SGTC_2655 perillic acid 100 µM 0.503003302400597 0.341376758054175 no 1132 0.307480975167392 1438 5702197 An apoptosis inducer.
SGTC_1537 2',6'-dihydroxyflavanone 78 µM 0.501423330996811 0.34187839895364 no 1133 0.30803661167006 1478 5106787 A p450 inhibitor.
SGTC_89 0302-0250 142.109 µM 0.501306202391373 0.341915598415042 no 1134 0.308077820422622 1542 4203518 YLR208W SEC13
SGTC_656 4090-1979 187 µM 0.500810306945695 0.342073109337822 no 1135 0.308252315561067 1570 22330961
SGTC_29 0299-0004 12.984 µM 0.499856911024012 0.342376013016344 no 1136 0.308587917195032 1416 16871 A napthoquinone isolated from Swertia calycina.
SGTC_78 0336-0123 156.75 µM 0.498954312879751 0.342662871185577 no 1137 0.308905785095802 1440 6765896
SGTC_3169 9102970 49.47 µM 0.498881052649219 0.342686158283921 no 1138 0.308931591429233 1521 17027839
SGTC_1396 3511-0007 98.6 µM 0.495764909059106 0.343677233799153 no 1139 0.310030142713111 1460 X1396
SGTC_1985 st071382 65.5 µM 0.494901219457985 0.343952117042795 no 1140 0.310334924926583 1481 6123237
SGTC_2379 9035213 200 µM 0.494078951563734 0.344213893818233 no 1141 0.310625211166551 1620 646551
SGTC_770 0389-1121 67.2 µM 0.492945460597657 0.344574873790217 no 1142 0.311025562212661 1585 6753108
SGTC_1655 st012546 55.1 µM 0.49229116646695 0.344783309645128 no 1143 0.31125676195986 1471 720985 YLR208W SEC13
SGTC_1682 st012968 530 nM 0.492123177388042 0.344836832856525 no 1144 0.311316134182617 1432 24207270
SGTC_1693 xanthone 101.9 µM 0.490698365846239 0.345290918622131 no 1145 0.311819901234205 1522 7020 An insecticide.
SGTC_689 0833-0039 98 µM 0.488104184142137 0.346118253033677 no 1146 0.312738023767118 1556 5374726
SGTC_2206 7254556 146.969 µM 0.488071711833437 0.346128613742927 no 1147 0.312749523619862 1534 4398905
SGTC_740 k014-0057 261 µM 0.486631189747087 0.346588346692972 no 1148 0.313259858209848 1604 4012779
SGTC_279 1273-0055 2.93 µM 0.483662284517655 0.347536565245923 no 1149 0.314312781922537 1557 2847562
SGTC_354 2783-3500 4.88 µM 0.483519135235182 0.347582308900712 no 1150 0.314363588178603 1435 6740761
SGTC_1772 st048439 82.2 µM 0.482082284876161 0.348041580303528 no 1151 0.314873746894209 1483 2927068 YDL195W SEC31
SGTC_2869 9037858 32.47 µM 0.481657898949705 0.348177272690995 no 1152 0.315024494252766 1442 27187042
SGTC_3288 9119690 36.221 µM 0.480093319920384 0.348677696172213 no 1153 0.315580518992092 1458 17595618 YKL019W RAM2
SGTC_3008 9078912 71.4286 µM 0.479617874768621 0.348829817364328 no 1154 0.315749566922936 1493 16648731
SGTC_3022 9087993 49.47 µM 0.478822068964153 0.349084494017618 no 1155 0.3160326076354 1562 17173644
SGTC_753 1322-0200 289 µM 0.475754528909979 0.35006681450779 no 1156 0.317124634042109 1512 5403907
SGTC_1168 k815-0004 80.5 µM 0.475739660424167 0.350071578303898 no 1157 0.317129931026865 1481 642433
SGTC_229 benomyl 22.8748 µM 0.471391498930778 0.351465719300508 no 1158 0.318680592795201 1495 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C
SGTC_1563 conessine 56.1 µM 0.468606174394799 0.352359823995302 no 1159 0.31967558155187 1584 441082 An anti-amoebic, histamine inhibitor.
SGTC_486 niguldipine 82 µM 0.46842304129266 0.35241863940232 no 1160 0.319741046949289 1537 1236 A calcium channel blocker.
SGTC_1781 st038725 66.3 µM 0.467454367618281 0.352729799321899 no 1161 0.320087416375239 1524 4270275 YIL048W NEO1
SGTC_1864 st057645 30.4 µM 0.465578611478725 0.35333261469121 no 1162 0.320758577789716 1553 688666
SGTC_1932 st074806 40.9 µM 0.465288047802566 0.353426026668249 no 1163 0.32086259643027 1609 17251235
SGTC_159 3970-0959 50 µM 0.465135162295662 0.353475180670695 no 1164 0.320917333428633 1586 6615653
SGTC_1091 telmisartan 47.6 µM 0.463349740054618 0.354049389956296 no 1165 0.321556849052249 1614 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension.
SGTC_1953 st076800 12.1 µM 0.463222134893394 0.35409044175625 no 1166 0.321602575888629 1477 297591
SGTC_287 k060-0039 29.6 µM 0.462691095821612 0.354261300311051 no 1167 0.321792900794717 1606 5861974
SGTC_218 alverine citrate 93.75 µM 0.461231329773819 0.354731122146994 no 1168 0.322316323189607 1587 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_645 0845-0943 5.41 µM 0.460649478759309 0.354918451009405 no 1169 0.322525053461568 1522 1885106
SGTC_2414 st077232 92.9 µM 0.460554474917155 0.354949041143944 no 1170 0.32255913997176 1468 729801
SGTC_215 1287-0124 461.5 µM 0.459821320419234 0.355185139821549 no 1171 0.322822239252178 1628 5560863
SGTC_3171 9103192 49.47 µM 0.458873386055347 0.355490486747915 no 1172 0.323162545760048 1592 13018434
SGTC_1775 st081588 35.1725 µM 0.458059569188113 0.355752706010908 no 1173 0.323454822487813 1529 1426443 YGL099W LSG1
SGTC_1213 1315-0166 115 µM 0.4565198372303 0.356249008464697 no 1174 0.324008104632737 1481 768401
SGTC_700 3453-2283 142 µM 0.455912886065806 0.356444714278964 no 1175 0.324226311403777 1622 565664
SGTC_1246 0422-0085 105 µM 0.454897817881195 0.356772098138111 no 1176 0.324591376426309 1622 264295
SGTC_322 k048-0136 19.3 µM 0.454059593572694 0.357042525167757 no 1177 0.324892967407506 1536 6823282
SGTC_561 1550-0330 72.9 µM 0.451069184901158 0.358007872088617 no 1178 0.325969843092946 1517 6812934
SGTC_1706 st031321 9.9705 µM 0.451053107033481 0.358013064716643 no 1179 0.325975636827219 1624 6103185
SGTC_2162 5663267 200 µM 0.45060941118796 0.358156374397374 no 1180 0.326135541260253 1637 6456493
SGTC_1376 2910-0861 41.3 µM 0.449924621509737 0.358377594392651 no 1181 0.326382396726938 1584 1112859
SGTC_278 4092-0821 23.9 µM 0.448944659119036 0.358694252048869 no 1182 0.326735789419095 1596 877900
SGTC_2771 fluoxetine 41.05 µM 0.448372252727734 0.358879260098146 no 1183 0.326942281789448 1596 3386 A selective serotonin reuptake inhibitor.
SGTC_3074 9116018 49.47 µM 0.447710584855108 0.359093159697484 no 1184 0.327181040776987 1589 17027303
SGTC_1092 toremifene 6.32 µM 0.445320164521347 0.359866286615241 no 1185 0.328044198803738 1556 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_814 3342-0569 96 µM 0.441923040985978 0.360965995139952 no 1186 0.32927244841049 1586 4346283
SGTC_524 r073-0010 27.8 µM 0.441373517352332 0.361143993914432 no 1187 0.329471305542582 1511 2772106
SGTC_23 0213-0011 39.996 µM 0.440763916217721 0.361341487854087 no 1188 0.329691959465278 1646 627608
SGTC_841 0251-0215 91.2 µM 0.440260781364691 0.361504517498778 no 1189 0.329874121050708 1599 3888614
SGTC_2183 6420625 130.508 µM 0.439299622034265 0.361816029662469 no 1190 0.330222224016443 1542 2897619
SGTC_1312 1218-2183 165 µM 0.43892214350556 0.36193839567909 no 1191 0.330358975592699 1573 6744073
SGTC_364 0083-0097 67.7 µM 0.437993481006604 0.362239497308828 no 1192 0.330695504546384 1597 5207356
SGTC_1849 st056239 19.2 µM 0.437105281134319 0.362527559452699 no 1193 0.33101749873862 1462 5393181
SGTC_210 3551-0445 56.827 µM 0.43618419356054 0.362826369998167 no 1194 0.33135154758941 1605 2865180 YOR207C RET1
SGTC_41 0478-0632 82.643 µM 0.436006685719792 0.362883965025353 no 1195 0.331415939410971 1664 3750424
SGTC_1585 2',4'-dihydroxychalcone 10.4 µM 0.435542880368176 0.363034468124048 no 1196 0.331584210548473 1665 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_3015 9080845 49.47 µM 0.433342281047375 0.36374884230016 no 1197 0.332383062907046 1689 5296973
SGTC_2626 ethyl orsellinate 100 µM 0.432760431851442 0.363937805636958 no 1198 0.332594410897181 1540 75653 A natural product.
SGTC_1111 tnp00062 510.699 nM 0.431882911517973 0.364222854720879 no 1199 0.332913257638919 1694 676306
SGTC_1 0258-0098 57.368 µM 0.430570101640375 0.364649441191336 no 1200 0.333390492300141 1557 6790032 YDR047W HEM12
SGTC_2260 7964312 200 µM 0.429749440874701 0.364916193161472 no 1201 0.333688957265537 1682 231951
SGTC_2871 9038510 12.99 µM 0.429461056552479 0.365009946680573 no 1202 0.333793864362934 1723 4945164
SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM 0.429266237627259 0.365073286729788 no 1203 0.333864742032937 1682 688798
SGTC_1486 3970-0793 4.53 µM 0.429144230761628 0.365112955802637 no 1204 0.33390913274317 1647 2844330
SGTC_247 mechlorethamine 29.705 µM 0.423942851903723 0.366805459454339 no 1205 0.335803745757712 1612 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links.
SGTC_3054 9094397 49.47 µM 0.422827315168038 0.367168788514217 no 1206 0.336210628444533 1516 2598354
SGTC_1969 st069479 40.1 µM 0.422000856167992 0.367438042029134 no 1207 0.336512196261521 1671 3895485
SGTC_2031 5180455 200 µM 0.42174250993004 0.367522222478615 no 1208 0.336606486182256 1564 29949
SGTC_1068 loratadine 26.9 µM 0.421641833352734 0.36755502901372 no 1209 0.336643233399317 1570 3957 A H1 histamine antagonist.
SGTC_1344 1488-0097 29.1 µM 0.421457649929459 0.367615049645561 no 1210 0.33671046487325 1616 747966
SGTC_1794 st048918 76.9 µM 0.420034904560187 0.368078794564333 no 1211 0.337229977608763 1677 672303
SGTC_2338 7999974 200 µM 0.419522165604804 0.368245969389306 no 1212 0.337417279424799 1754 315925
SGTC_296 1222-0039 74.9 µM 0.419467973443421 0.368263639809631 no 1213 0.337437077994229 1547 5984176
SGTC_2161 5662504 8.5105 µM 0.418646454765553 0.368531546249199 no 1214 0.337737266804057 1570 2859334
SGTC_2890 9046729 58.44 µM 0.417984531896283 0.368747453215005 no 1215 0.337979213288546 1532 903329
SGTC_3097 9117246 49.47 µM 0.417224408082598 0.368995442616099 no 1216 0.33825713682663 1584 16423892
SGTC_1973 st070275 50.2 µM 0.415169098861306 0.369666257436271 no 1217 0.33900905916166 1608 17118334
SGTC_1906 st060206 94.7 µM 0.412326808541756 0.37059458187487 no 1218 0.340049950790137 1708 5133468
SGTC_2876 9059903 25.97 µM 0.412041216063317 0.370687901409681 no 1219 0.340154606868302 1607 6916095
SGTC_2880 9042983 58.44 µM 0.411161702519845 0.37097533698274 no 1220 0.340476984143728 1605 6464714
SGTC_1300 1094-0077 113 µM 0.410506657975762 0.371189460189161 no 1221 0.340717160225807 1581 5532636
SGTC_1485 3909-9022 254 µM 0.406910778672982 0.372365602275938 no 1222 0.34203675956757 1612 714516
SGTC_1569 carminic acid 40.6 µM 0.406383142237343 0.372538282377051 no 1223 0.342230552079303 1716 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_88 0180-0332 8.668 µM 0.406371332748984 0.372542147573358 no 1224 0.342234889993114 1651 3101745
SGTC_1733 st037357 54.9 µM 0.403331104595547 0.373537627565813 no 1225 0.343352331220566 1519 1272339 YGL099W LSG1
SGTC_2252 omeprazole 400 µM 0.400528825083227 0.37445594276538 no 1226 0.344383528507492 1696 4594 A proton pump inhibitor.
SGTC_1365 1672-3266 55.4 µM 0.40011152238081 0.374592755168668 no 1227 0.344537188942972 1713 6415873
SGTC_1669 st015249 58.4 µM 0.399471254582138 0.37480269721585 no 1228 0.344773000122857 1741 722793
SGTC_2823 7987624 58.44 µM 0.39618247592353 0.37588166229214 no 1229 0.345985209041077 1622 2239440
SGTC_1124 fisetin 1.16336 µM 0.39581518029707 0.376002223133587 no 1230 0.346120688627005 1604 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster.
SGTC_228 caffeine 993.056 µM 0.394539771529544 0.376420956267794 no 1231 0.346591285014113 1696 2519 Caffeine is a phosphodiesterase inhibitor.
SGTC_303 1348-1668 34.2 µM 0.391654840825395 0.377368652202099 no 1232 0.347656630671946 1661 5380509
SGTC_2007 4011539 71.82 µM 0.390978570386858 0.377590913272941 no 1233 0.34790653799008 1591 45595301
SGTC_1085 doxorubicin 7.67 µM 0.390927298735441 0.377607765718656 no 1234 0.347925487486626 1747 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_81 0411-0046 9.971 µM 0.387449550144906 0.378751406994983 no 1235 0.349211713490352 1605 12925265
SGTC_1055 3448-0672 86 µM 0.386821252661784 0.378958133275925 no 1236 0.349444271174206 1651 748378
SGTC_1513 0337-0559 19 µM 0.386748104283062 0.378982203254471 no 1237 0.3494713499499 1570 775073
SGTC_3138 9097216 49.47 µM 0.385125903898309 0.379516119926103 no 1238 0.350072068460682 1650 25237486
SGTC_237 nikkomycin 200 µM 0.384760066213257 0.379636560299355 no 1239 0.350207594075641 1737 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine.
SGTC_620 0109-0052 432 µM 0.384172369089183 0.379830065252856 no 1240 0.350425348087203 1740 493037
SGTC_2413 inermin 26.06 µM 0.384164469246153 0.379832666557546 no 1241 0.350428275478457 1779 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1
SGTC_1503 4585-0012 61.3 µM 0.383873077203316 0.379928621564744 no 1242 0.350536260857789 1720 2922052
SGTC_2788 5282734 71.43 µM 0.382685055787272 0.380319911869504 no 1243 0.350976648137945 1772 743706
SGTC_1887 st057648 70.8 µM 0.382635922378586 0.380336097237336 no 1244 0.350994865701632 1772 688672
SGTC_1862 st057513 3.81 µM 0.38225198661725 0.380462579321357 no 1245 0.351137232244954 1633 5393163
SGTC_1438 4092-1045 4 µM 0.379941167658774 0.381224114712216 no 1246 0.351994543671589 1626 1351342
SGTC_3257 9139206 32.98 µM 0.379589967992711 0.381339893678167 no 1247 0.35212490439849 1719 4910041
SGTC_757 1066-0008 322 µM 0.377084199751164 0.382166270597017 no 1248 0.353055516383252 1721 6842497
SGTC_784 4579-0127 173 µM 0.376684854537105 0.382298020306251 no 1249 0.353203909764452 1792 1948547
SGTC_2850 9015429 58.44 µM 0.376241786390913 0.382444210784573 no 1250 0.3533685763492 1608 6457570
SGTC_108 0509-0257 621.132 µM 0.374535630431108 0.383007313816826 no 1251 0.354002926546541 1721 536624
SGTC_1385 3091-4834 14.1 µM 0.374168603499355 0.383128480465478 no 1252 0.354139440514275 1722 4072814
SGTC_411 enrofloxacin 100 µM 0.373966368251776 0.383195249301128 no 1253 0.354214668990697 1815 71188 A bacterial gyrase inhibitor.
SGTC_1003 4049-0218 100 µM 0.372463916493432 0.383691398727871 no 1254 0.354773736465924 1722 295161
SGTC_174 3553-0389 74.3 µM 0.372243186786821 0.38376430562162 no 1255 0.354855897141421 1714 738071
SGTC_827 3253-0474 693 µM 0.370981685371485 0.384181057690579 no 1256 0.355325586434879 1781 5402065
SGTC_1909 st060837 51.5 µM 0.370176431050298 0.384447153148369 no 1257 0.355625518253859 1637 678937
SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM 0.369918872983651 0.384532274446097 no 1258 0.355721469386632 1602 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1
SGTC_2353 9059630 146.67 µM 0.368837091343097 0.384889857133124 no 1259 0.356124577987186 1743 4779114
SGTC_844 0330-0132 15.3 µM 0.364106630887263 0.386454656474974 no 1260 0.357889192734103 1754 2828079
SGTC_1183 1254-0324 198 µM 0.363257116469185 0.386735865704706 no 1261 0.358206412277941 1766 5799357
SGTC_2944 9067346 25.62 µM 0.361913594134314 0.38718072452725 no 1262 0.358708300476997 1711 6473075
SGTC_2386 9075165 157.42 µM 0.361671653880451 0.387260850055929 no 1263 0.35879870599669 1697 16452277
SGTC_3126 9127922 49.47 µM 0.361127584820395 0.387441051838578 no 1264 0.359002036510333 1718 45595682
SGTC_2066 5222451 176 µM 0.360402510908505 0.387681242154478 no 1265 0.359273074592322 1650 2281147
SGTC_604 1000-0114 314 µM 0.35946721167147 0.387991135868664 no 1266 0.359622801085377 1790 1572745
SGTC_3160 9100216 49.47 µM 0.358642403433141 0.388264479687421 no 1267 0.35993131044611 1708 17191039
SGTC_2487 5918373 44.05 µM 0.357960814246494 0.388490402080131 no 1268 0.360186319369747 1782 2876279
SGTC_1466 k213-0079 57.5 µM 0.356717903200892 0.388902479637357 no 1269 0.360651500671887 1691 3657981
SGTC_1470 k295-0292 231 µM 0.355748347699238 0.38922401510105 no 1270 0.361014517115888 1777 5045612
SGTC_1633 st005664 67.9 µM 0.354623037448179 0.389597298914929 no 1271 0.361436007531289 1649 2063822
SGTC_3337 9144342 33.5465 µM 0.352854621853179 0.390184117014343 no 1272 0.362098715917493 1767 17682949
SGTC_2615 purpurogallin-4-carboxylic acid 100 µM 0.352322566826717 0.390360719309904 no 1273 0.362298182958606 1654 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase.
SGTC_2054 5233173 129 µM 0.350765573342507 0.390877654028074 no 1274 0.362882113329998 1733 6889
SGTC_1260 0700-1617 7.75 µM 0.35070911979847 0.390896400700751 no 1275 0.362903291505502 1725 2853078
SGTC_69 0096-0274 206.684 µM 0.350689473243955 0.390902924841805 no 1276 0.362910661879484 1782 6741392
SGTC_259 usnic acid 108.925 µM 0.349551222662149 0.391280962435318 no 1277 0.363337761408782 1764 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_977 1348-1378 135 µM 0.349280233142238 0.391370979058458 no 1278 0.363439468389081 1681 X977
SGTC_3196 9111891 49.47 µM 0.349192308956049 0.391400186745765 no 1279 0.363472469901872 1690 18891510
SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM 0.346135620952483 0.392415972800495 no 1280 0.364620397222464 1665 6708760
SGTC_2470 5664817 21.68 µM 0.345800714445148 0.392527312265626 no 1281 0.364746244097 1713 2859561
SGTC_2644 guaiazulene 100 µM 0.345719621100088 0.392554273022194 no 1282 0.364776718507122 1780 3515 A coloring agent.
SGTC_1550 gossypolone 36.6 µM 0.345485022954331 0.392632271764469 no 1283 0.364864883944048 1722 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_657 3534-0529 86.7 µM 0.344903096017371 0.392825768327503 no 1284 0.365083611493085 1784 1049549
SGTC_1307 1187-1599 12.2 µM 0.344479365448094 0.392966679675016 no 1285 0.365242905762282 1699 1538471
SGTC_1572 epiandrosterone 68.9 µM 0.340908101871412 0.394154856821966 no 1286 0.366586382691077 1759 441302 A steroid.
SGTC_607 4491-0986 66.8 µM 0.340542411287259 0.394276579719703 no 1287 0.366724044798947 1825 698981 YDR232W HEM1
SGTC_849 0386-0493 241 µM 0.338248729652617 0.39504028417581 no 1288 0.367587878351303 1717 726119
SGTC_91 0417-1751 58.384 µM 0.338061831516373 0.395102531610955 no 1289 0.36765829647797 1733 6795624
SGTC_1843 st055809 45.5 µM 0.337294601632428 0.395358089709323 no 1290 0.367947414397475 1708 16413835
SGTC_1198 1612-1005 86.7 µM 0.337217255916447 0.395383855443925 no 1291 0.367976565008572 1822 6998509
SGTC_2307 7538926 6.34 µM 0.333995819246243 0.396457399057826 no 1292 0.369191356730704 1704 96582
SGTC_3070 9117005 49.47 µM 0.332900183262082 0.39682269911088 no 1293 0.369604815549894 1795 8779016
SGTC_222 nsc-310342 10.666 µM 0.331993564639452 0.397125046674746 no 1294 0.369947059180556 1842 432556
SGTC_644 1498-1197 63.3 µM 0.33075089471146 0.397539564170459 no 1295 0.370416327701441 1789 6741615
SGTC_1237 0330-0133 46.1 µM 0.329960650285471 0.397803226286832 no 1296 0.370714847504636 1725 X1237 YHR072W ERG7
SGTC_2934 9036370 36.88 µM 0.32992457879227 0.397815262521551 no 1297 0.370728475597224 1846 6462800
SGTC_2904 7225135 42.03 µM 0.329294617377521 0.398025481952621 no 1298 0.370966506088378 1821 4446116
SGTC_3088 9117578 49.47 µM 0.329148466552496 0.398074257019503 no 1299 0.371021736138463 1763 678341
SGTC_1801 st050089 28.441 µM 0.328795637162866 0.398192013701679 no 1300 0.371155080475301 1720 5008493 YIL048W | YNL267W NEO1 | PIK1
SGTC_2522 biochanin a 4.94 µM 0.328617036843566 0.39825162502981 no 1301 0.371222584552152 1789 5280373 A possible chelator.
SGTC_2394 5221648 200 µM 0.328144643653429 0.398409306882933 no 1302 0.371401150169729 1846 788586
SGTC_2173 5763948 167 µM 0.325536136616307 0.399280308041274 no 1303 0.372387668802935 1766 2867177
SGTC_3339 9145883 14.936 µM 0.325084170783073 0.39943127412027 no 1304 0.372558684388828 1811 2030670
SGTC_276 colchicine 750 µM 0.32436344486225 0.399672042815963 no 1305 0.372831445837612 1759 2833 A microtubule depolymerizer.
SGTC_2498 4'-Methoxychalcone 54.63 µM 0.322180579592092 0.400401492279372 no 1306 0.373657947996184 1650 641818 YHR062C RPP1
SGTC_603 3794-0023 45.9 µM 0.322102356470406 0.400427638614542 no 1307 0.37368757656864 1841 3802260
SGTC_348 k064-0012 10.7 µM 0.321634198512939 0.400584131271436 no 1308 0.373864916360365 1700 5066323
SGTC_2100 5377183 190 µM 0.316925692416919 0.402158942036305 no 1309 0.375649993225624 1849 2844202
SGTC_3263 9137018 49.47 µM 0.313555953877492 0.40328696498933 no 1310 0.376929158593634 1662 43844957
SGTC_191 3914-0123 66.505 µM 0.312500809622296 0.403640341440181 no 1311 0.377329973929592 1728 3144412
SGTC_1699 st031318 29.054 µM 0.310910194206978 0.404173200181767 no 1312 0.377934447220706 1829 5340658
SGTC_1240 0356-0016 42.1 µM 0.309047451534309 0.404797448020151 no 1313 0.37864271563396 1800 4305613
SGTC_3101 9120531 49.47 µM 0.308575202675949 0.404955748030361 no 1314 0.378822343146042 1863 24824904
SGTC_3333 9141820 12.094 µM 0.307897501746027 0.405182943699034 no 1315 0.379080163414785 1738 1939433
SGTC_1721 st082152 9.2685 µM 0.307845335955469 0.405200433331268 no 1316 0.379100011270724 1740 5296051
SGTC_2673 kobusone 100 µM 0.307367536003997 0.405360634194981 no 1317 0.379281817733836 1808 6710676 An epoxy ketone and protein crosslinker.
SGTC_305 1682-2595 20.8 µM 0.307298892076362 0.405383651022789 no 1318 0.379307939457403 1800 226033
SGTC_2047 4141938 200 µM 0.306506531068538 0.405649359326193 no 1319 0.379609503953844 1781 3807862
SGTC_2334 9017922 200 µM 0.305131143529976 0.406110681419986 no 1320 0.380133136207186 1892 3163164
SGTC_2131 toluylene red 5.2905 µM 0.304965496487467 0.406166250308977 no 1321 0.380196215559965 1704 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain.
SGTC_2649 anisomycin 9.56 µM 0.304183471812114 0.406428618216239 no 1322 0.380494058091652 1786 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_2785 7756463 72.73 µM 0.302568881324272 0.406970443294151 no 1323 0.381109216279977 1725 2201551
SGTC_897 1000-0139 31.4 µM 0.302549855920115 0.406976828912415 no 1324 0.38111646674442 1908 6151020
SGTC_456 gingerol 170 µM 0.301410618926284 0.407359243337023 no 1325 0.381550698938051 1808 442793 A herb.
SGTC_3356 9151811 4.48 µM 0.298442269890812 0.408356060583282 no 1326 0.382682815692695 1751 1859254 YPR165W RHO1
SGTC_1539 benzyladenosine 56 µM 0.297802085278084 0.408571122416433 no 1327 0.382927111453818 1780 92208 A nucleotide analog.
SGTC_1453 4237-0541 195 µM 0.29756014787844 0.408652405364732 no 1328 0.383019447394405 1909 739892
SGTC_933 2914-0560 114 µM 0.297424146395574 0.4086980990813 no 1329 0.383071355578446 1941 463887
SGTC_45 0kpi-0036 14.9 µM 0.294429832687961 0.409704440647045 no 1330 0.384214736728262 1803 2795021
SGTC_2524 avocatin b 10.57 µM 0.294073940053939 0.409824090244422 no 1331 0.384350701860355 1886 6710748
SGTC_1061 3448-9325 110 µM 0.293704372860319 0.409948346058628 no 1332 0.384491906278907 1894 723482
SGTC_1602 st001878 87.6 µM 0.292855529659969 0.410233778184605 no 1333 0.384816290719112 1872 595405 YLR310C CDC25
SGTC_1285 0929-0069 65.5 µM 0.292358602812929 0.410400896953116 no 1334 0.385006228174537 1801 1206237
SGTC_1551 6-bromo-3'-methylflavone 63.5 µM 0.29088055051608 0.410898068751698 no 1335 0.385571338443929 1869 688751
SGTC_837 0091-0265 12.5 µM 0.289755934937902 0.41127645115511 no 1336 0.386001480546618 1777 759367
SGTC_3161 9100388 49.47 µM 0.287123556742782 0.412162449816602 no 1337 0.387008857778192 1842 25236368
SGTC_1393 3470-5649 58.2 µM 0.286970745954482 0.412213896252112 no 1338 0.387067359951883 1799 4108395
SGTC_2424 5537928 59.2 µM 0.286889296156579 0.412241318373371 no 1339 0.387098543289513 1746 5382802
SGTC_3180 9109287 49.47 µM 0.286314777809164 0.412434756574834 no 1340 0.387318520317678 1804 18891271
SGTC_2698 st077697 67.5 µM 0.286136307267182 0.412494851278373 no 1341 0.387386862179625 1717 3154499
SGTC_2274 7947094 46.08 µM 0.284807339955007 0.412942406335568 no 1342 0.387895874275757 1772 2971028
SGTC_2370 9071495 200 µM 0.283122735061344 0.41350989172151 no 1343 0.388541377120709 1774 21791103
SGTC_2281 7943571 200 µM 0.280376121072087 0.414435518416999 no 1344 0.389594477634945 1984 1244024
SGTC_2607 solasodine 47.35 µM 0.279882919350708 0.41460178108487 no 1345 0.389783666054046 1775 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity.
SGTC_787 4152-0075 138 µM 0.279858932551604 0.414609867637677 no 1346 0.389792867873588 1831 9566539
SGTC_3233 9132340 49.47 µM 0.279383146874148 0.414770274420559 no 1347 0.389975401605907 1772 17682950
SGTC_392 N-ethylmaleimide 8.33 µM 0.277996741217166 0.415237769338838 no 1348 0.39050743016436 1775 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides.
SGTC_2417 cerulenin 830 nM 0.277593201995281 0.415373865035681 no 1349 0.390662325575848 1801 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1
SGTC_3113 9123498 49.47 µM 0.277093267851074 0.415542484500117 no 1350 0.390854245495594 1947 8897275
SGTC_1305 1181-0477 144 µM 0.276050379865438 0.415894283286792 no 1351 0.391254685715206 1934 6252086
SGTC_949 1165-0505 146 µM 0.275195294685256 0.416182780611343 no 1352 0.391583100880008 1761 6244267
SGTC_1413 3910-0535 34.4 µM 0.273005083903797 0.416921941828823 no 1353 0.392424653792533 1909 2876951
SGTC_796 1234-0020 70.7 µM 0.271851905745578 0.417311239299031 no 1354 0.39286794628167 1781 46495034
SGTC_707 0865-0008 204 µM 0.271543814506264 0.417415260505965 no 1355 0.392986402990817 1881 723043
SGTC_1877 wortmannin 25 µM 0.270835632433793 0.417654386751697 no 1356 0.39325872650217 1938 312145 A covalent inhibitor of PI 3-kinase.
SGTC_1990 st072050 59.8 µM 0.270693737832134 0.417702302845791 no 1357 0.393313296773254 1787 17233948
SGTC_1062 mesoridazine 14.2 µM 0.270334863713608 0.417823495755055 no 1358 0.393451323059986 1830 4078 A neuroleptic.
SGTC_870 0573-2213 57.6 µM 0.270012174829381 0.417932475462199 no 1359 0.393575443607387 1792 3916321
SGTC_1277 0873-0036 22 µM 0.269553070300913 0.418087536834865 no 1360 0.393752054336828 1894 5965735
SGTC_539 4859-0462 2.54 µM 0.268918682126234 0.418301820756706 no 1361 0.393996130056262 1969 46499474 YNL221C | YBR257W POP1 | POP4
SGTC_1841 st054148 70 µM 0.26834472765303 0.418495712253056 no 1362 0.394216990281364 1790 675442
SGTC_2550 chrysin dimethyl ether 71.87 µM 0.267837455038237 0.418667093982085 no 1363 0.394412219354094 1852 88881 An O-methylated flavonoid and antioxidant.
SGTC_2484 5809818 12.04 µM 0.266255444732753 0.419201674162737 no 1364 0.395021242412221 1816 2870548
SGTC_3020 9089140 49.47 µM 0.266192707597558 0.419222876872153 no 1365 0.395045399489145 1807 17217859
SGTC_806 3966-4455 5.86 µM 0.265031488363926 0.419615366058142 no 1366 0.395492602349012 1777 714982
SGTC_1581 himbacine 57.9 µM 0.264803231937006 0.419692525575761 no 1367 0.395580523511962 1809 5281825 An alkaloid muscarinic receptor antagonist.
SGTC_2846 9008642 19.48 µM 0.263924311763902 0.419989663462518 no 1368 0.395919120783942 1798 2992898
SGTC_1683 st010134 710 nM 0.263775763224519 0.420039888005091 no 1369 0.395976355739001 1757 3818134
SGTC_2889 9059656 51.95 µM 0.263223024046328 0.420226781599412 no 1370 0.396189342866828 1887 3949838
SGTC_690 glyoxal 20.3 µM 0.262019561905031 0.420633761482052 no 1371 0.396653180349684 1862 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins.
SGTC_1888 azatryptophan 97.5 µM 0.261870158590228 0.420684291762334 no 1372 0.396710773484358 1839 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides
SGTC_1955 wogonin 32.4 µM 0.261491703625613 0.42081229634463 no 1373 0.396856673284885 1936 5281703 A flavanone.
SGTC_1482 3346-2049 8.48 µM 0.261339217597531 0.420863873964188 no 1374 0.396915462911256 1924 3826804
SGTC_2725 haloperidol 53.21 µM 0.260736658632432 0.421067699735304 no 1375 0.397147797047535 1878 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_1380 2291-0730 164 µM 0.256496670460702 0.422502542741404 no 1376 0.398783675529338 1804 2999191
SGTC_2561 acetosyringone 100 µM 0.254752918724244 0.42309294077694 no 1377 0.399456970531053 1965 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent.
SGTC_2726 cimetidine 79.27 µM 0.253139376106123 0.423639406638578 no 1378 0.400080255898141 1953 2756 A P450 inhibitor, histamine H2-receptor antagonist.
SGTC_695 3505-6186 243 µM 0.252147771089003 0.423975310991786 no 1379 0.400463423271764 1893 1819379
SGTC_404 fumagillin 50 µM 0.249757502541676 0.424785236627294 no 1380 0.401387443194007 1878 12015870 A methionine aminopeptidase binder.
SGTC_418 lividomycin a 100 µM 0.248783228649004 0.425115453776866 no 1381 0.401764232454421 1968 72394 An antibiotic.
SGTC_429 1112-0049 25.5 µM 0.248097705641426 0.425347834171205 no 1382 0.402029405383894 1801 2836170
SGTC_2992 9074591 71.4286 µM 0.246877620314737 0.425761486018585 no 1383 0.402501468365409 1951 17741321
SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM 0.245530236443608 0.426218391481463 no 1384 0.403022949618974 1905 16623 A steroid.
SGTC_2020 4017018 200 µM 0.24220153084968 0.427347597696434 no 1385 0.404312004456657 1857 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope.
SGTC_972 1319-0219 195 µM 0.23900269347104 0.428433309600396 no 1386 0.405551747086562 1855 23903702
SGTC_715 0868-0130 184 µM 0.238502437695757 0.428603149762048 no 1387 0.405745712445582 2027 2876258
SGTC_1236 0330-0013 258 µM 0.237651488183367 0.42889208314008 no 1388 0.406075706262481 1867 4617066
SGTC_2210 7115885 190.385 µM 0.236564314980838 0.429261279887177 no 1389 0.406497403477351 1907 2927039
SGTC_2852 9023854 51.95 µM 0.235587812374837 0.429592946409536 no 1390 0.406876265807607 1938 19798528
SGTC_1355 1499-0035 1.68 µM 0.235387771434627 0.429660895925959 no 1391 0.406953888224411 1858 1548538
SGTC_1362 1611-0397 101 µM 0.234953264508939 0.429808495567097 no 1392 0.407122503687688 1863 27816
SGTC_944 3370-0224 231 µM 0.234581253564648 0.42993487345961 no 1393 0.407266880538745 1824 4580514
SGTC_2342 7990637 118.86 µM 0.234314226744776 0.430025591042081 no 1394 0.407370520988458 1906 2033102 YER133W GLC7
SGTC_1608 st001473 40.5 µM 0.234004782896322 0.430130723671453 no 1395 0.407490632764373 1822 7292267
SGTC_1040 k898-0338 155 µM 0.232674232727978 0.43058283049476 no 1396 0.408007189707311 2060 20969351
SGTC_3116 9124943 49.47 µM 0.232519013967456 0.430635578120546 no 1397 0.408067460423555 1788 41905195 YPL160W CDC60
SGTC_1131 3454-3128 32.3 µM 0.232414198107824 0.430671198147318 no 1398 0.408108161160446 1943 710982
SGTC_3311 9131146 2.8755 µM 0.232209451655797 0.430740779646151 no 1399 0.408187668510223 1903 4900406 YPR165W RHO1
SGTC_2119 5528445 120.635 µM 0.231751550986253 0.430896401426965 no 1400 0.40836549463822 1996 791935
SGTC_205 1486-1330 71.903 µM 0.231048286090689 0.431135433398784 no 1401 0.408638644916692 1909 4118834
SGTC_2653 dihydrofissinolide 100 µM 0.230960831055414 0.431165160164784 no 1402 0.408672615830837 1931 6857746
SGTC_590 k048-0076 22.4 µM 0.230892946355486 0.431188235063708 no 1403 0.408698985343762 2012 6832814
SGTC_2830 7992007 71.43 µM 0.228492924636314 0.432004184258824 no 1404 0.409631527989433 1825 1952075
SGTC_1684 st024538 14.6195 µM 0.228029951159858 0.432161617506299 no 1405 0.409811478088039 1853 6732859
SGTC_3201 9113999 49.47 µM 0.226458976298783 0.432695904661264 no 1406 0.410422231308076 1939 16649224
SGTC_131 0141-0277 33.849 µM 0.226442041381937 0.432701664883707 no 1407 0.410428816339626 1997 1547771
SGTC_3083 9117465 49.47 µM 0.226318122481224 0.432743814946108 no 1408 0.410477002161248 1831 16420915
SGTC_984 1492-0255 2.91 µM 0.22522893775413 0.43311432563787 no 1409 0.410900589326903 1926 1585198
SGTC_1189 1431-2119 7.28 µM 0.222711068328954 0.433971060126115 no 1410 0.411880193212378 1946 3107275
SGTC_2806 7952793 58.44 µM 0.222397842194443 0.434077660759546 no 1411 0.412002095722057 1922 2972490
SGTC_2471 5466956 24.79 µM 0.221030989195792 0.434542899521294 no 1412 0.412534151881653 1951 724419
SGTC_2547 epiafzelechin trimethyl ether 100 µM 0.220919209944348 0.434580950089901 no 1413 0.412577669785065 2061 6708630 An antioxidant.
SGTC_281 1672-3440 14.9 µM 0.220096861104742 0.434860902945969 no 1414 0.412897859675446 2017 6833000
SGTC_2865 9030313 51.95 µM 0.220009612844227 0.434890606858091 no 1415 0.412931834078069 1834 42562754
SGTC_1221 2958-7315 257 µM 0.219953706351669 0.434909640571629 no 1416 0.412953604364248 1952 4562705
SGTC_208 k072-0098 12.366 µM 0.218183944846668 0.435512244633509 no 1417 0.413642896955031 2026 5948901
SGTC_575 k072-0246 11.9 µM 0.217563139549551 0.435723664487994 no 1418 0.413884753439986 1922 6796779
SGTC_3313 9133968 57.047 µM 0.217339141472278 0.435799953210106 no 1419 0.41397202777502 1949 1494643
SGTC_1847 st056231 15 µM 0.215629070625021 0.436382443526863 no 1420 0.414638446871321 1913 5393180
SGTC_3098 9119039 49.47 µM 0.215627961195216 0.436382821469652 no 1421 0.414638879299006 1975 17161528
SGTC_1926 methyl fluorone black 53.6 µM 0.215531138964396 0.436415805541221 no 1422 0.414676618554797 1955 72721 Reacts with homocysteine.
SGTC_729 4092-0585 94.1 µM 0.215126422149325 0.436553683707077 no 1423 0.414834377123613 1855 2169061
SGTC_1447 4239-0816 81.9 µM 0.214895206132912 0.43663245740719 no 1424 0.414924511267575 1856 1341554
SGTC_2929 9013348 24.6 µM 0.214314566510717 0.436830288389156 no 1425 0.415150879748378 1936 2995952
SGTC_1747 st037496 66.6 µM 0.212440653834926 0.437468860757471 no 1426 0.415881636167927 1921 723305
SGTC_2282 7944268 200 µM 0.212192618724261 0.437553395813968 no 1427 0.415978382517311 1991 2970414
SGTC_1952 st077036 64.1 µM 0.212117560275946 0.437578977714637 no 1428 0.416007660145943 2060 2937007
SGTC_878 0828-0289 13.7 µM 0.210542311994025 0.438115923954477 no 1429 0.416622215727655 1886 745350 YLR208W SEC13
SGTC_100 0086-0128 49.5915 µM 0.209798141519166 0.438369624954091 no 1430 0.416912611819229 1838 93297
SGTC_1821 st053465 65.6 µM 0.208960141202676 0.438655344537865 no 1431 0.417239677204071 1908 675086
SGTC_923 1900-2434 73.3 µM 0.208028020899026 0.438973192265163 no 1432 0.417603544208627 1883 5910570
SGTC_1223 0764-0573 147 µM 0.20759449360293 0.43912103603121 no 1433 0.417772802087263 1954 1609797
SGTC_2374 9071832 200 µM 0.207272679204965 0.439230788368734 no 1434 0.417898454829958 2046 17381698
SGTC_3189 9110682 49.47 µM 0.205809740446112 0.43972977120245 no 1435 0.418469766153341 1911 17122418
SGTC_2405 ticlatone 3.52 µM 0.205780985962596 0.439739579816226 no 1436 0.418480997170103 1787 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W
SGTC_1293 1000-1278 195 µM 0.20563101686895 0.439790737269737 no 1437 0.418539573648115 1999 678847
SGTC_120 rhodamine 6G 52.259 µM 0.204552276434134 0.440158746753075 no 1438 0.418960972385038 2058 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase
SGTC_581 0958-0271 211 µM 0.203731434774238 0.440438809399024 no 1439 0.41928168797559 1904 4591145
SGTC_1576 erythromycin ethylsuccinate 23.2 µM 0.201772088118502 0.441107438320831 no 1440 0.42004745159615 1983 3256 An antibiotic and ribosome inhibitor.
SGTC_683 panaxydol 45 µM 0.201602813892855 0.441165211218914 no 1441 0.42011362261521 2031 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis.
SGTC_2319 6033012 152.6 µM 0.201082588486101 0.44134277076724 no 1442 0.420316998152315 1910 847246
SGTC_375 3970-0961 9.27 µM 0.200586651004351 0.441512051515701 no 1443 0.420510898442465 1969 2898222
SGTC_3023 9089636 49.47 µM 0.200456650617959 0.441556426947438 no 1444 0.420561728833407 2108 17249241
SGTC_2534 helenine 20.12 µM 0.200309300507339 0.441606725567801 no 1445 0.420619344600091 1923 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58
SGTC_1817 st052116 64.4 µM 0.199481508780005 0.441889313464587 no 1446 0.420943053268168 2036 4361398
SGTC_2602 kawain 100 µM 0.198756884590908 0.442136706764547 no 1447 0.421226462068407 2087 5369129
SGTC_873 0591-4978 488 µM 0.198386731391387 0.442263089154462 no 1448 0.421371248975111 2093 3305145
SGTC_480 am 92016 50 µM 0.196191264396251 0.443012813649948 no 1449 0.422230232597896 1919 2129 K+ channel blocker.
SGTC_818 4072-2707 53.5 µM 0.195785781419389 0.443151303417162 no 1450 0.422388919739619 1967 882871
SGTC_1910 st062352 60.4 µM 0.195059578370487 0.44339935014313 no 1451 0.422673153241809 1962 2245730
SGTC_1261 0712-0010 12.7 µM 0.194946558943063 0.443437955804777 no 1452 0.42271739230122 2058 2840123
SGTC_587 k089-0003 57 µM 0.194552149749777 0.44357268399526 no 1453 0.422871783052854 2077 9659696
SGTC_3347 9188721 44.724 µM 0.194174688608785 0.443701628925217 no 1454 0.42301955061562 2004 44118411 YKL104C | YBL026W GFA1 | LSM2
SGTC_162 k030-0015 37.8 µM 0.19306473844356 0.444080834749489 no 1455 0.423454133862085 2052 1809920 YMR134W ERG29
SGTC_1981 st071826 47 µM 0.191967184009166 0.444455856016073 no 1456 0.42388395534353 1958 11838600
SGTC_711 k292-0785 179 µM 0.191724685369973 0.444538721629791 no 1457 0.423978934278694 2002 4146315
SGTC_3152 9099253 49.47 µM 0.191359125618516 0.444663643748977 no 1458 0.424122120646793 2024 25236131
SGTC_48 0382-0018 55 µM 0.191186084985297 0.444722778551083 no 1459 0.424189902553855 2088 762596
SGTC_2970 9090938 41.86 µM 0.190890177204118 0.444823904748671 no 1460 0.42430581806056 2101 17217104
SGTC_3222 9128301 49.47 µM 0.190007737072134 0.445125499107173 no 1461 0.424651533836371 1960 4911358
SGTC_3353 9151644 39.2805 µM 0.189972966444908 0.445137383426167 no 1462 0.424665157200713 1973 4909158
SGTC_1512 0259-0544 12.2 µM 0.189696231699112 0.445231970879724 no 1463 0.424773586932211 1969 18476
SGTC_1464 k208-0027 110 µM 0.187978430809633 0.445819181770406 no 1464 0.42544677973992 2053 X1464
SGTC_1493 4348-0038 111 µM 0.187458709504985 0.445996866126966 no 1465 0.425650497404982 2007 800424
SGTC_1959 st077091 55.8 µM 0.186960163163588 0.446167321296482 no 1466 0.425845933670177 1977 821356 YKL052C ASK1
SGTC_1752 st044819 83.042 µM 0.184641071541881 0.446960359121687 no 1467 0.426755284672993 1945 441209 YML126C ERG13
SGTC_2366 9070441 60.58 µM 0.184589921986726 0.446977852653859 no 1468 0.426775345596553 1972 6837235
SGTC_2221 6807166 181.081 µM 0.184295615210317 0.447078509786163 no 1469 0.426890776784418 2046 674925
SGTC_2189 6047310 154.431 µM 0.184059910900306 0.447159126494468 no 1470 0.426983227790122 1979 711535
SGTC_1657 st012939 43.4 µM 0.180101185989239 0.448513432086025 no 1471 0.428536565774445 2087 24207257
SGTC_1303 1160-0052 261 µM 0.180017867196992 0.448541942492479 no 1472 0.428569270673043 2096 3562476
SGTC_556 4058-0063 51.5 µM 0.179679250674399 0.448657814580436 no 1473 0.42870219194003 1973 6615692
SGTC_1497 4476-2978 41.3 µM 0.178068734926352 0.449208981030432 no 1474 0.429334497751872 2043 1528379
SGTC_1271 0832-2808 169 µM 0.177034608051436 0.449562941787657 no 1475 0.429740602804389 2100 3663794
SGTC_2895 9054447 58.44 µM 0.176749900784745 0.449660398396685 no 1476 0.429852421363159 1972 2697450
SGTC_503 tyrphostin 8 294 µM 0.175189632641439 0.450194539132534 no 1477 0.430465315155015 2103 92970 A tyrosine kinase inhibitor. YOR207C RET1
SGTC_2314 7727897 200 µM 0.175050257420277 0.450242257119716 no 1478 0.430520071743411 1959 900724
SGTC_1050 3232-1156 69.3 µM 0.174799950581303 0.450327956644233 no 1479 0.430618413585085 1943 700529
SGTC_2713 st079149 53.4 µM 0.174405689392701 0.45046294764935 no 1480 0.430773321678143 2004 3103253
SGTC_1038 k292-0204 154 µM 0.172503997418621 0.451114147773794 no 1481 0.431520659492416 1954 4454212
SGTC_2355 9061122 103.12 µM 0.171045507769081 0.451613670512516 no 1482 0.432093991397841 2095 5302957
SGTC_2393 9031399 185.94 µM 0.170147143495515 0.451921392320906 no 1483 0.43244720942851 2056 1526623 YDL150W RPC53
SGTC_3272 9137413 49.47 µM 0.169868587889844 0.452016813427782 no 1484 0.43255674264248 2133 17614870
SGTC_3351 9150312 21.596 µM 0.168467396829555 0.452496842832197 no 1485 0.433107795312125 2117 4904905
SGTC_309 k408-0051 1.48 µM 0.166934008235253 0.453022240905776 no 1486 0.433710986942779 2022 3640463
SGTC_3245 9134821 49.47 µM 0.165264061443413 0.453594522620424 no 1487 0.434368072315201 1964 17014901
SGTC_18 0111-0177 500 nM 0.164737980796648 0.453774827625732 no 1488 0.434575110513466 2042 721752
SGTC_2240 6690706 185.951 µM 0.164648621484637 0.453805454925701 no 1489 0.434610279512329 1896 805876
SGTC_1363 1636-0063 10.4 µM 0.164515213173596 0.453851180233413 no 1490 0.434662785766811 2011 6072185
SGTC_874 0599-0792 117 µM 0.162016594239075 0.454707686913452 no 1491 0.435646393102157 2149 765305
SGTC_3148 9097893 49.47 µM 0.161312059220206 0.454949234149081 no 1492 0.435923812881209 1963 17174100
SGTC_2714 st079313 56.9 µM 0.160837963809579 0.455111785395725 no 1493 0.436110511838892 2020 2939799
SGTC_2448 5185112 27.17 µM 0.16027556685176 0.455304621994035 no 1494 0.436332002438238 1995 5718189
SGTC_1451 4152-0210 104 µM 0.157637461445941 0.456209324454662 no 1495 0.437371241327163 2121 659563
SGTC_1190 1486-1332 13 µM 0.157240608993612 0.456345439383074 no 1496 0.437527612499417 2102 4150046
SGTC_3178 9107506 49.47 µM 0.157214960736282 0.4563542365587 no 1497 0.43753771897947 2074 8897194
SGTC_2724 maprotiline 69.64 µM 0.155222616556097 0.457037661934385 no 1498 0.438322909472727 2104 4011 A tricyclic antidepressant.
SGTC_2416 tofa 880 nM 0.154151267233141 0.457405215020902 no 1499 0.438745232959878 1875 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_1253 0550-0034 176 µM 0.153184805519605 0.457736815067587 no 1500 0.439126269844488 2024 5969915
SGTC_514 4466-0038 2.65 nM 0.152938570223006 0.457821304901748 no 1501 0.439223359525045 2025 5722064
SGTC_1573 oleylamine 1.06 µM 0.149839828862556 0.458884726584481 no 1502 0.440445492591645 2028 5356789 An amine of the fatty acid oleic acid.
SGTC_2952 9073731 13.78 µM 0.149342637266217 0.459055379690115 no 1503 0.440641636407738 2026 16457353
SGTC_3112 9123419 49.47 µM 0.147506359108992 0.459685718106708 no 1504 0.441366180395833 2187 17015854
SGTC_1093 fluphenazine 7.97 µM 0.147299992203519 0.459756563950103 no 1505 0.441447619316207 2046 6602611 An atypical antipsychotic.
SGTC_997 3996-0078 137 µM 0.147293332855055 0.459758850128459 no 1506 0.441450247347387 2055 735687
SGTC_270 tamoxifen 5.46 µM 0.14548008602802 0.460381393558178 no 1507 0.442165918761473 2165 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen. YIL048W NEO1
SGTC_212 3807-4682 38.772 µM 0.145452750171413 0.460390779545871 no 1508 0.442176709416632 2121 3125501 YBL034C STU1
SGTC_802 4112-3352 742 µM 0.144492290953165 0.460720574967785 no 1509 0.442555871750806 2122 704594
SGTC_422 cantharidin 155 µM 0.143166135016895 0.461175985002347 no 1510 0.443079487303304 1978 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_835 0312-0010 67.2 µM 0.142658696641988 0.461350255936143 no 1511 0.443279869144392 2040 1626196
SGTC_2442 5158906 48.48 µM 0.142557045538266 0.461385167143056 no 1512 0.443320011794468 2114 1893835
SGTC_1999 st074831 12.5 µM 0.141927401187781 0.461601419759188 no 1513 0.443568675191429 2022 17112523
SGTC_234 nsc-17383 10.7 µM 0.141678017381839 0.461687074270419 no 1514 0.443667169676663 2140 408974
SGTC_2283 7944793 200 µM 0.141480037076674 0.461755074763988 no 1515 0.443745364755227 2046 2970533
SGTC_11 0438-0307 1.3 µM 0.14144513270841 0.461767063518277 no 1516 0.443759150948747 2171 4011476
SGTC_1245 0418-0076 17.2 µM 0.141159530375112 0.461865161890729 no 1517 0.443871957982068 2058 6790114
SGTC_2464 5717415 7.67 µM 0.140217979882151 0.462188581008382 no 1518 0.44424388317682 1991 5285744
SGTC_2306 7482397 179.52 µM 0.139255638625016 0.462519167511436 no 1519 0.444624071746615 2144 891448
SGTC_1301 naphtanilide LB 4.81 µM 0.138466948045527 0.46279012030129 no 1520 0.444935694797756 2157 67238 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_868 0527-0199 213 µM 0.138284116907468 0.462852933977577 no 1521 0.445007938890002 2043 2849450
SGTC_1007 4101-0031 70 µM 0.136457883285964 0.463480407481307 no 1522 0.445729658657052 2170 1146276
SGTC_1046 2001-0062 216 µM 0.13636103705308 0.463513685317503 no 1523 0.445767936920026 2042 739778
SGTC_1205 4161-2785 76 µM 0.136022675434177 0.46362995351032 no 1524 0.445901677580251 1961 3498106
SGTC_550 4123-0385 25.7 µM 0.133500225205936 0.464496817872685 no 1525 0.446898893088336 2065 5731123
SGTC_331 k048-0133 24.5 µM 0.133330616119323 0.464555111765401 no 1526 0.446965957795174 2088 6813582
SGTC_704 1310-0270 142 µM 0.131954560292693 0.465028084081687 no 1527 0.447510116505122 2042 5718033
SGTC_1101 ebselen 5.29 µM 0.131726862533681 0.465106352212618 no 1528 0.447600168714762 2189 3194 A potent scavenger of hydrogen peroxide and hydroperoxides.
SGTC_2430 5571206 200 µM 0.130906310799342 0.465388417331384 no 1529 0.447924711175402 2180 1731771
SGTC_3319 9138450 16.7555 µM 0.130737226686884 0.46544654225545 no 1530 0.44799159121735 2037 2029690
SGTC_2768 sulfasalazine 50.2 µM 0.130695310222608 0.465460951714483 no 1531 0.44800817121134 2173 5384001 An antioxidant and salicylic acid derivative.
SGTC_2486 5283202 22.39 µM 0.130616468349608 0.465488054999579 no 1532 0.448039357240924 2026 1377751
SGTC_615 k087-0205 167 µM 0.130030741676359 0.465689413883461 no 1533 0.448271052410761 2086 9642773
SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM 0.128466107439794 0.466227340813702 no 1534 0.448890059143778 2146 23847180
SGTC_2666 tannic acid 100 µM 0.126981481573733 0.466737817643961 no 1535 0.449477527727494 2160 16134267 A thiamine antagonist.
SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM 0.126278627972895 0.466979507416783 no 1536 0.449755686613303 2087 115019
SGTC_1878 temozolomide 1 mM 0.125948393531616 0.467093069111252 no 1537 0.449886387575682 2204 5394 DNA alkylating agent.
SGTC_283 0987-0079 11.7 µM 0.125699490706153 0.467178664094302 no 1538 0.449984902513845 2160 411556
SGTC_1082 camptothecin 424.86 nM 0.123790153085975 0.467835314786671 no 1539 0.450740714271331 2122 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_371 0195-0006 7.36 µM 0.122581070257915 0.468251182420385 no 1540 0.451219422562859 2113 3928593
SGTC_1492 4158-0558 28.5 µM 0.121586193121257 0.468593399374629 no 1541 0.451613374324096 2174 3967268
SGTC_678 1218-2179 85.9 µM 0.121108624541328 0.468757681250276 no 1542 0.451802499033034 2200 6820081 YOR116C RPO31
SGTC_2977 9011197 71.43 µM 0.121034094151747 0.468783319917113 no 1543 0.451832015233637 2173 2704722
SGTC_563 tetrahydrosecaminediol 614 µM 0.120184122017375 0.469075721889419 no 1544 0.452168647697834 2192 334274 A psychoactive constituent of the cannabis plant.
SGTC_2123 5259487 200 µM 0.119630088955726 0.469266325786217 no 1545 0.452388091672722 2173 2173474
SGTC_65 0798-0905 34.986 µM 0.119030294136929 0.469472681031249 no 1546 0.45262567757046 2182 3602145
SGTC_975 1335-0046 28.5 µM 0.117975688971173 0.469835530470376 no 1547 0.453043460364921 2058 16486740
SGTC_316 k060-0003 58.6 µM 0.117314092349699 0.470063173455764 no 1548 0.45330557903115 2175 6152314
SGTC_171 k064-0041 9.68 µM 0.116808888716146 0.470237011140585 no 1549 0.453505749899344 2074 53325
SGTC_552 k242-0005 476 µM 0.115977177754641 0.470523210472838 no 1550 0.453835314617441 2087 4088318
SGTC_2344 7990960 76.95 µM 0.115545195179053 0.470671865636886 no 1551 0.454006499881592 2099 140813
SGTC_1806 st050005 60.3 µM 0.115248725076334 0.470773890200851 no 1552 0.454123989457425 2069 5194765
SGTC_2441 5730946 39.09 µM 0.114544527359611 0.471016234169131 no 1553 0.454403075461707 2145 1774275
SGTC_138 0850-0259 40.9225 µM 0.114318887634705 0.471093888536718 no 1554 0.454492505242622 2207 6813004
SGTC_1077 5-fluorocytosine 377 nM 0.113686786113205 0.471311433396196 no 1555 0.454743043878453 2136 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_1135 dihydrocapsaicin 536.708 nM 0.111370286043229 0.472108755672779 no 1556 0.455661360877046 2139 107982 A Capsaicinoid.
SGTC_2387 9077560 195.08 µM 0.110304793657349 0.472475528037188 no 1557 0.456083827838253 2058 5303272
SGTC_1174 0739-0097 51.1 µM 0.108594047856963 0.473064463415719 no 1558 0.456762240978292 2110 728447
SGTC_1960 st011366 51.8 µM 0.108589453737369 0.47306604505115 no 1559 0.456764062992359 2206 3972846
SGTC_1204 4049-0315 18.3 µM 0.108259010687354 0.473179809078072 no 1560 0.456895118097548 2165 588402
SGTC_143 4032-1194 15.74 µM 0.107058510013995 0.47359313249947 no 1561 0.457371281072346 2111 1806963
SGTC_3335 9143315 29.6265 µM 0.105084634663707 0.474272784644275 no 1562 0.458154325777684 2103 4899691
SGTC_2089 5281248 129.67 µM 0.104775825390723 0.474379121832909 no 1563 0.458276846494563 2154 2737878
SGTC_2493 resveratrol 26.09 µM 0.104411046508118 0.474504734274804 no 1564 0.458421578375945 2202 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase.
SGTC_1850 st056238 17 µM 0.104402671789064 0.474507618158259 no 1565 0.458424901245063 2213 5393177
SGTC_593 1203-0218 61.7 µM 0.104394146590925 0.47451055386144 no 1566 0.458428283823325 2229 3666956
SGTC_1708 st033234 31.827 µM 0.103489784687243 0.474821984143645 no 1567 0.458787128300418 2189 674664
SGTC_2841 9004761 38.96 µM 0.102737380009182 0.475081097459744 no 1568 0.459085702821324 2035 2991039
SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM 0.102316982610265 0.475225878620606 no 1569 0.45925253793808 2154 521171
SGTC_377 3970-0964 33.1 µM 0.101485674209698 0.475512183522788 no 1570 0.459582464583702 2168 16481235
SGTC_2998 9066762 71.4286 µM 0.101109323502803 0.475641803909352 no 1571 0.459731838446425 2188 4945196
SGTC_2154 5570129 200 µM 0.100027954250388 0.476014256727207 no 1572 0.460161066227578 2226 673366
SGTC_2947 9072639 7.68 µM 0.0990713413339451 0.476343757569676 no 1573 0.46054081321047 2153 16488146
SGTC_1964 st076914 61 µM 0.0988878890728287 0.476406948697991 no 1574 0.460613642445854 2246 24208661
SGTC_387 norethindrone acetate 66.7 µM 0.0979419806898391 0.476732781362919 no 1575 0.460989182223398 2128 541197
SGTC_821 1114-0266 29.2 µM 0.0972506159616902 0.47697094241087 no 1576 0.461263686389918 2156 3123235
SGTC_2291 7917025 104.35 µM 0.096815704332705 0.477120764816916 no 1577 0.46143637613451 2158 2964612
SGTC_1713 st033146 12.748 µM 0.0958902225409565 0.477439594135456 no 1578 0.4618038800388 2229 674619
SGTC_2832 7992762 51.95 µM 0.0955594288522658 0.477553556375699 no 1579 0.461935244384193 2023 2985177
SGTC_186 3455-3465 67.277 µM 0.0948388273636414 0.477801818240009 no 1580 0.462221423036004 2237 755278
SGTC_1210 3013-0140 750 nM 0.0940138098810798 0.478086064108848 no 1581 0.462549093313406 2245 905973
SGTC_3158 9100007 49.47 µM 0.092711736147296 0.478534694292312 no 1582 0.463066286537362 2161 19297233
SGTC_2557 derrustone 83.84 µM 0.090752985832839 0.479209633788887 no 1583 0.463844433846377 2066 629853 An antioxidant.
SGTC_332 4112-0506 40.9 µM 0.0906272124120857 0.479252974422501 no 1584 0.463894404262824 2199 2790355
SGTC_3156 9099931 49.47 µM 0.0905018979998122 0.479296157128998 no 1585 0.463944192879358 2174 18111053
SGTC_795 0685-0265 78 µM 0.090364978276971 0.479343339244048 no 1586 0.463998593042461 2278 302754
SGTC_1259 0671-0132 43 µM 0.0901142174214764 0.479429751413022 no 1587 0.464098225659341 2155 X1259
SGTC_930 2810-3379 265 µM 0.0891931449109593 0.479747161186601 no 1588 0.464464206617008 2266 1015764
SGTC_1318 1280-3875 124 µM 0.0884322548029124 0.480009380376428 no 1589 0.464766563042341 2179 373245
SGTC_3234 9132280 49.47 µM 0.0870060537496731 0.480500903325249 no 1590 0.46533335008088 2160 17612295
SGTC_2336 9001819 198.65 µM 0.086830496034675 0.48056140923353 no 1591 0.465403123416213 2207 2989602
SGTC_2295 7971645 200 µM 0.0855435498781848 0.481004968384827 no 1592 0.465914637268698 2184 2978226 YKL099C UTP11
SGTC_3305 9127027 53.8275 µM 0.0845972544998423 0.481331133797557 no 1593 0.466290790918372 2177 41905295
SGTC_1816 st051957 91.6 µM 0.0841078489705896 0.481499825109953 no 1594 0.466485342091499 2228 674121
SGTC_2428 5615643 7.78 µM 0.0840852893046015 0.481507601194685 no 1595 0.466494310327231 2210 2253075
SGTC_17 0960-0276 49.807 µM 0.0829378284617509 0.481903128355497 no 1596 0.466950487440117 2271 6821114
SGTC_2497 7-hydroxyflavone 100 µM 0.0823320607112546 0.482111942339951 no 1597 0.467191330097701 2251 5281894
SGTC_2683 piperine 63.03 µM 0.082010243280351 0.482222877911078 no 1598 0.467319283968346 2201 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_1525 8-methoxypsoralen 92.5 µM 0.0818006112739535 0.482295142128462 no 1599 0.467402634989335 2273 4114 Related to psoralen; DNA damaging agent.
SGTC_285 1486-1325 46 µM 0.0814670426522036 0.482410130898538 no 1600 0.467535266943173 2254 22310230
SGTC_2067 5224629 34.075 µM 0.0813284628448226 0.482457902973796 no 1601 0.46759036944141 2167 2835000
SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM 0.0806105117426074 0.482705403467891 no 1602 0.467875853125948 2277 1241132 A phosphatase inhibitor.
SGTC_776 4476-4378 112 µM 0.0802364735320252 0.482834348937629 no 1603 0.468024590989488 2123 2892008
SGTC_2920 7982904 15.77 µM 0.0797338144360358 0.483007637837614 no 1604 0.468224482514298 2202 6456808
SGTC_473 2-arachidonoylglycerol 10 µM 0.0791038246987292 0.483224827789834 no 1605 0.468475020689562 2104 5282280 An endocannabinoid.
SGTC_2381 9035592 200 µM 0.0773989214484986 0.48381262064591 no 1606 0.469153099384955 2109 4749657
SGTC_1069 diphenylcyclopropenone 8.49 µM 0.0773747486771918 0.48382095485412 no 1607 0.46916271409241 2250 65057 A dermal irritant. YDR527W RBA50
SGTC_2792 7535235 81.82 µM 0.0763883646353163 0.484161043072557 no 1608 0.469555063117271 2178 1281891
SGTC_1408 3909-7976 48.8 µM 0.0749818069236559 0.484646019801396 no 1609 0.470114593554996 2207 24152374
SGTC_1630 st005209 31.3 µM 0.0746700841231506 0.484753503954418 no 1610 0.470238605306919 2288 3367314
SGTC_2657 nystatin 74.44 µM 0.0743473229885958 0.484864795367748 no 1611 0.470367011447913 2231 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_1146 3579-1023 7 µM 0.0741550426085932 0.484931096213821 no 1612 0.470443509055388 2273 X1146
SGTC_745 0469-0705 296 µM 0.0736407468210612 0.485108434320495 no 1613 0.47064812393341 2270 3486736
SGTC_1053 3366-3204 134 µM 0.0727135554885554 0.48542815338947 no 1614 0.471017030692749 2185 3632071 YPR165W RHO1
SGTC_2981 9013952 38.96 µM 0.0714217021588912 0.485873632730266 no 1615 0.471531068944289 2082 2996344
SGTC_853 0419-0306 21 µM 0.0710269940403136 0.486009746392645 no 1616 0.47168813580167 2139 762713
SGTC_748 act1.228 77.9 µM 0.0704553544475756 0.486206877117284 no 1617 0.471915617094695 2230 4421505 YNR035C ARC35
SGTC_2893 9048488 25.97 µM 0.0700957936447559 0.486330873900172 no 1618 0.472058707327195 2201 6467338
SGTC_94 0334-0113 514.748 µM 0.0678179434523155 0.487116434940254 no 1619 0.472965279918692 2279 6795178
SGTC_759 3486-0358 89.3 µM 0.0666361611696465 0.487524015485616 no 1620 0.473435678630259 2304 875103
SGTC_804 1595-0054 20.9 µM 0.0664851528057003 0.487576097152761 no 1621 0.47349578894968 2154 761523 Stimulates phospholipase C.
SGTC_1421 4029-0249 71.4 µM 0.066374775297806 0.487614165672441 no 1622 0.473539726151209 2296 2894095
SGTC_2003 4023581 200 µM 0.0653352237033168 0.487972706075614 no 1623 0.473953548892704 2221 16641307
SGTC_436 n,n-dimethylsphingosine 3.3 µM 0.064500709397676 0.488260536351281 no 1624 0.474285771135984 2262 5282309
SGTC_1138 3761-0006 1.03 µM 0.0629412951689865 0.488798406347749 no 1625 0.474906625613106 2284 12061087
SGTC_2543 pimpinellin 60.67 µM 0.06285476987407 0.488828251082763 no 1626 0.474941075998457 2254 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo.
SGTC_1128 3448-9350 235 µM 0.0620722810942308 0.489098153824572 no 1627 0.475252635450975 2138 619386
SGTC_1441 4106-0040 13 µM 0.0610516106091293 0.489450219727644 no 1628 0.47565905317827 2293 2904180
SGTC_1756 st041558 35.5 µM 0.0601166845818946 0.489772716508199 no 1629 0.476031350810845 2315 3955792
SGTC_2782 7736369 71.43 µM 0.0600797113194307 0.48978547033851 no 1630 0.47604607439519 2225 2950836 YOL077C BRX1
SGTC_1384 3089-0840 101 µM 0.0583406796707319 0.490385356335537 no 1631 0.476738632493596 2293 1069836
SGTC_2030 5175110 200 µM 0.0582892644820045 0.490403092550417 no 1632 0.476759109339466 2252 2831986
SGTC_2043 5101342 149 µM 0.0571291417262101 0.490803294181871 no 1633 0.477221161292542 2253 678451
SGTC_1109 tnp00067 928.257 nM 0.0565035656913242 0.491019099824643 no 1634 0.477470327527156 2190 676295
SGTC_1242 0402-0103 60.1 µM 0.0554021216897824 0.491399072505923 no 1635 0.477909052785799 2297 432868
SGTC_2658 polymyxin b sulfate 77.05 µM 0.053723617070394 0.491978132635108 no 1636 0.478577683134857 2282 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides. YIL048W NEO1
SGTC_203 k066-0004 30.888 µM 0.0530318692695309 0.492216780738947 no 1637 0.478853257713476 2319 6795412
SGTC_2566 crystal violet carbinol 226 nM 0.0516928706364347 0.492678733646697 no 1638 0.47938670902716 2132 68050 Cationic dye that binds acidic phospholipids including cardiolipin.
SGTC_1509 1326-1131 80 µM 0.0512952185866518 0.492815925041536 no 1639 0.479545139052929 2297 768313
SGTC_3058 9093861 49.47 µM 0.0498670856051958 0.493308642974038 no 1640 0.480114153269152 2287 17217477
SGTC_419 nsc-638432 893 µM 0.0493805972735564 0.493476487923437 no 1641 0.480307995214283 2206 368090
SGTC_2098 5376439 882.5 nM 0.04912554561649 0.493564484603125 no 1642 0.480409622761553 2285 2844116
SGTC_3018 9082602 49.47 µM 0.0481310894938437 0.493907589959376 no 1643 0.480805884538741 2262 17332089
SGTC_2756 carbadox 75.1 µM 0.0477286890866024 0.494046426676195 no 1644 0.480966234783691 2288 2553 A substituted quinoxaline antibiotic. YLR208W SEC13
SGTC_357 1325-0123 420 µM 0.0476123460852124 0.494086567626418 no 1645 0.481012596218334 2304 1098503
SGTC_1045 1348-1485 165 µM 0.0473474019644699 0.494177979525335 no 1646 0.481118174557985 2324 6810614
SGTC_1166 k206-0078 225 µM 0.046410389044969 0.494501273249328 no 1647 0.481491578088148 2318 5404595
SGTC_2734 clemastine 41.6 µM 0.04615192429427 0.494590450926563 no 1648 0.481594580233328 2328 26987 Clemastine is a selective histamine H1 antagonist.
SGTC_35 0133-0054 64.071 µM 0.0448773764353473 0.495030209992482 no 1649 0.482102524830932 2289 99677
SGTC_1449 4112-4002 201 µM 0.044732088579153 0.495080339262243 no 1650 0.482160428150951 2174 2059539
SGTC_1506 4226-2149 212 µM 0.0431599135582833 0.495622798113304 no 1651 0.482787029819718 2242 991114
SGTC_632 0781-2353 4.65 µM 0.0429644206529838 0.495690251022223 no 1652 0.482864947927804 2287 6811515 YHR007C ERG11
SGTC_773 4358-1457 44.6 µM 0.04279343828586 0.495749246911503 no 1653 0.482933097344517 2334 1186886
SGTC_457 grayanotoxin iii 135 µM 0.0410760012998386 0.496341837649295 no 1654 0.483617653320481 2276 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity.
SGTC_1188 1403-0014 4.57 µM 0.0405314343431968 0.496529738771007 no 1655 0.483834723321447 2312 9614867
SGTC_1552 6-methylflavone 10.6 µM 0.0397574831994752 0.49679678950213 no 1656 0.484143236451343 2343 689013
SGTC_1845 st056753 3.01 µM 0.0390414381094691 0.497043861113529 no 1657 0.484428675474332 2326 5375839
SGTC_2617 dihydrotanshinone i 20.83 µM 0.0389866615154128 0.497062761844559 no 1658 0.484450511549048 2321 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12
SGTC_1741 st038134 10.228 µM 0.0384875148017906 0.497234993329397 no 1659 0.484649492927205 2305 1272587
SGTC_2156 5649887 115 µM 0.0383459192280703 0.497283851235854 no 1660 0.484705939719526 2310 54680440 YKL052C | YBR257W ASK1 | POP4
SGTC_2571 chrysanthemic acid 100 µM 0.0376482559022417 0.497524582290256 no 1661 0.484984066262977 2251 2743 An insecticide.
SGTC_3056 9094900 49.47 µM 0.037613720359029 0.497536498918611 no 1662 0.484997834199561 2316 25236784
SGTC_735 3076-0345 636 µM 0.0375621434516112 0.497554295742446 no 1663 0.485018395878177 2331 2888990
SGTC_1227 3909-8010 46.6 µM 0.0371322570730262 0.497702629989765 no 1664 0.4851897761656 2287 15982272
SGTC_3247 9135149 49.47 µM 0.036564351791716 0.497898588769886 no 1665 0.485416183830464 2344 8934436 YOR116C RPO31
SGTC_957 1187-1561 14.1 µM 0.0357917111185637 0.498165193406164 no 1666 0.485724221201559 2348 1538454
SGTC_2251 lansoprazole 556 µM 0.034962230808883 0.498451411833616 no 1667 0.486054928948267 2261 3883 Gastric proton pump inhibitor. YBR192W RIM2
SGTC_1423 4048-0112 5.59 µM 0.0345640262057415 0.498588815622958 no 1668 0.486213693639086 2353 X1423
SGTC_1444 4112-3581 28 µM 0.0333772094899572 0.49899833746854 no 1669 0.486686891863502 2327 2877249
SGTC_3106 9121286 49.47 µM 0.0328847902943556 0.4991682515017 no 1670 0.486883230911681 2320 15943471
SGTC_626 0214-0009 33 µM 0.0327206307962249 0.499224896368351 no 1671 0.486948685851326 2327 3437874
SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM 0.0325884892344891 0.499270493139181 no 1672 0.487001374608227 2210 688788
SGTC_1158 4092-0494 91.8 µM 0.0324483313418591 0.499318856035766 no 1673 0.48705725996177 2294 1148199
SGTC_1192 1488-0095 21.4 µM 0.0322811589904442 0.499376540557258 no 1674 0.48712391716071 2293 915875
SGTC_3011 9081274 71.4286 µM 0.0320319441774921 0.499462534689042 no 1675 0.487223288096008 2314 6625322
SGTC_1972 st070201 17.4 µM 0.0304743470178192 0.5 no 1676 0.487844375995368 2355 2829099
SGTC_329 k048-0121 21.3 µM 0.0303646832152791 0.499962159338114 no 1677 0.487888105285746 2264 6832902
SGTC_2988 9073640 71.4286 µM 0.0290564408896698 0.499510736525913 no 1678 0.488409788125152 2339 9102229
SGTC_2082 5219693 150 µM 0.0266944391352837 0.498695704888639 no 1679 0.489351724240288 2359 2834649
SGTC_1224 0823-0416 294 µM 0.0264766797918775 0.498620565135292 no 1680 0.489438566953863 2345 3598164
SGTC_107 0358-0022 2.6945 µM 0.0253924184816122 0.49824643213113 no 1681 0.489870979167493 2325 521106 YGL093W | YPR107C SPC105 | YTH1
SGTC_62 0180-0423 3.232 µM 0.0249186256261541 0.49808294659614 no 1682 0.490059935372691 2335 30102 YGL099W LSG1
SGTC_1703 st026983 48.3 µM 0.024621339234133 0.497980366012182 no 1683 0.490178499105331 2367 1104023
SGTC_2963 9082507 9 µM 0.0243589379423533 0.497889822867435 no 1684 0.490283150686771 2345 16459611
SGTC_3179 9107801 49.47 µM 0.0242309475291818 0.497845659044329 no 1685 0.490334196407092 2366 4818259
SGTC_1632 st005650 90 µM 0.0237581993941567 0.497682534833222 no 1686 0.490522741340178 2342 2759605
SGTC_2610 ononetin 44.17 µM 0.0235104264718774 0.497597039646372 no 1687 0.490621560831374 2333 259632
SGTC_200 k038-0079 37.545 µM 0.0226101760261927 0.497286405045957 no 1688 0.490980613304281 2320 3436683
SGTC_1631 benzylvanillin 81.9 µM 0.0219626123977616 0.49706296193205 no 1689 0.49123888966165 2326 75506
SGTC_2691 st077356 60.2 µM 0.0198244980623863 0.496325208266756 no 1690 0.49209168754717 2354 2839272
SGTC_1329 1447-1697 50.6 µM 0.0189126736745838 0.496010588083206 no 1691 0.492455384609727 2311 2840515
SGTC_156 3474-0145 5.642 µM 0.0188993640031414 0.496005995669351 no 1692 0.492460693451529 2379 2265471
SGTC_2128 5255449 168.493 µM 0.0187081381862773 0.495940014528271 no 1693 0.49253696802905 2372 736008
SGTC_1868 st057644 42.7 µM 0.0182249139221745 0.49577328184835 no 1694 0.492729713749881 2375 688665
SGTC_1831 st055328 12 µM 0.0181081075691981 0.495732978857173 no 1695 0.492776305053962 2374 1103068
SGTC_1811 st050069 61.5 µM 0.0179747017071922 0.495686948406631 no 1696 0.492829517631883 2373 3877702
SGTC_1215 3852-0577 11.2 µM 0.0172368523882101 0.495432361423057 no 1697 0.49312383129835 2371 2884876
SGTC_3248 9135562 49.47 µM 0.016624828915794 0.495221190703574 no 1698 0.493367958341859 2367 17650701
SGTC_1489 4065-0444 182 µM 0.0166023067292021 0.495213419741922 no 1699 0.493376942154438 2373 2877968
SGTC_2679 rapamycin 1 nM 0.0157034881191795 0.494903296618364 no 1700 0.493735472112151 2371 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2
SGTC_2951 9072950 58.06 µM 0.0148636140215138 0.49461351414521 no 1701 0.494070494259395 2389 16488155
SGTC_3200 9114385 49.47 µM 0.0145016563934003 0.494488628464897 no 1702 0.494214878896133 2362 17018030 YLR208W SEC13
SGTC_2061 5245884 80.95 µM 0.0140668111950394 0.494338595214362 no 1703 0.494388339332543 2385 573863
SGTC_1367 1812-0510 76.9 µM 0.0137019853228255 0.494212721125288 no 1704 0.494533869769045 2372 1142582 YDR527W RBA50
SGTC_2594 a-mangostin 100 µM 0.013167016819831 0.494028144600697 no 1705 0.494747272062115 2381 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis.
SGTC_2908 7930301 100 µM 0.0124888114830815 0.493794149893662 no 1706 0.495017814580025 2389 2223178
SGTC_1170 0310-0127 64.8 µM 0.0109803027396139 0.493273691310404 no 1707 0.495619581008102 2378 774975
SGTC_248 streptozotocin 5.23457 mM 0.0108066952726519 0.493213794797571 no 1708 0.495688836257455 2384 5300 DNA alkylating agent.
SGTC_1749 st037932 54.2 µM 0.009358705931547 0.492714228409925 no 1709 0.496266471014566 2377 594497
SGTC_1954 st077032 68.9 µM 0.0092720214688025 0.492684322022461 no 1710 0.496301051611382 2325 698907
SGTC_3254 9136651 49.47 µM 0.00799633963806472 0.492244212988107 no 1711 0.496809956025967 2395 16454030
SGTC_3278 9139605 49.47 µM 0.00789831601801127 0.492210395314971 no 1712 0.496849060557528 2387 7958859
SGTC_1925 st057770 10.1 µM 0.00755473893396325 0.492091863332244 no 1713 0.496986123890909 2387 5989122
SGTC_891 0929-0073 133 µM 0.00650046033516741 0.491728148098093 no 1714 0.497406709793914 2384 5603632
SGTC_876 0720-0963 56.8 µM 0.00596484368920625 0.4915433684995 no 1715 0.497620385767257 2394 765861
SGTC_1018 4259-0013 28.1 µM 0.00557595310373054 0.49140920829561 no 1716 0.497775528080329 2360 6801262
SGTC_945 3381-0768 11.3 µM 0.00327943913602195 0.490616972918264 no 1717 0.498691695417713 2399 1126236 YIL048W NEO1
SGTC_2308 7584454 197.62 µM 0.00309916750643988 0.49055478559454 no 1718 0.498763613026852 2397 893577
SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM 0.00178525652700991 0.490101539899712 no 1719 0.499287786068334 2400 17037758
SGTC_52 0329-0193 875 nM 0.000538919718553817 0.489671616340677 no 1720 0.499785002148934 2400 3739292
SGTC_1089 terbinafine 2.25 µM -0.000527663252735411 0.489303708330766 no 1721 0.499789492828438 2407 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_2421 5690543 90.72 µM -0.000775316976330311 0.489218283741543 no 1722 0.499690693308417 2386 3397993
SGTC_223 busulfan 5 mM -0.00130343491940489 0.489036118711405 no 1723 0.499480004848138 2409 2478 A DNA alkylator.
SGTC_526 4469-0568 170 µM -0.00363886215949679 0.48823058194845 no 1724 0.498548307235745 2414 2901964
SGTC_2625 euphol 100 µM -0.00450975509676386 0.487930205223275 no 1725 0.498200874116051 2416 6708538 A triterpene alcohol.
SGTC_2699 st077704 54.6 µM -0.00465639432519277 0.487879629053837 no 1726 0.498142374142305 2424 645852
SGTC_1916 st067606 49.2 µM -0.00546458737116019 0.487600885140812 no 1727 0.497819955902678 2421 19590279
SGTC_553 k007-0256 45.7 µM -0.0061538535648853 0.487363163604462 no 1728 0.497544983120791 2424 6287000
SGTC_2126 5251174 33.877 µM -0.00699360416088515 0.487073547464958 no 1729 0.497209978351409 2426 790722
SGTC_3072 9116419 49.47 µM -0.00762211323957038 0.486856789495135 no 1730 0.496959246205671 2425 17170162
SGTC_353 1988-1175 58.3 µM -0.00851063353195204 0.486550366424571 no 1731 0.496604789437502 2372 2788357
SGTC_3194 9111903 49.47 µM -0.00854640003867039 0.486538031831582 no 1732 0.496590521184664 2435 17087251
SGTC_1589 2',5'-dimethoxyflavone 47.2 µM -0.00876093452943738 0.486464046805198 no 1733 0.496504937510425 2420 688667
SGTC_532 1548-0774 215 µM -0.0100330496188642 0.486025350928427 no 1734 0.495997459456461 2434 5932993
SGTC_1559 coumarin 343 70.1 µM -0.0103109761441941 0.485929508672033 no 1735 0.495886588551065 2428 108770 A hepatotoxic, DNA x-linker.
SGTC_3292 9120825 59.784 µM -0.0115941110851064 0.485487033471072 no 1736 0.495374722508976 2419 24824900
SGTC_1521 st012942 49.4 µM -0.0122771580985208 0.485251499351917 no 1737 0.495102245590256 2446 24207259
SGTC_1304 1165-0502 251 µM -0.0175875697133207 0.483420499583676 no 1738 0.492983936538222 2450 767425
SGTC_1465 k213-0056 144 µM -0.0184172641399941 0.483134456253214 no 1739 0.492652989993184 2428 24048857 YMR208W ERG12
SGTC_2581 avocatin a 64 µM -0.0199241293683518 0.482614975548807 no 1740 0.492051948255839 2461 6710728 A skin care supplement.
SGTC_2357 9067248 200 µM -0.0206196062379938 0.48237522491419 no 1741 0.491774550137131 2453 9150235
SGTC_2320 7373003 200 µM -0.0211975221839422 0.482176005714535 no 1742 0.491544045425136 2457 5415828
SGTC_1766 st045414 44.774 µM -0.0212392895755078 0.482161607830102 no 1743 0.491527386397242 2446 253960
SGTC_1744 st037937 38.9 µM -0.0214571508098292 0.482086507973845 no 1744 0.491440492142915 2474 1016152
SGTC_2485 5633444 17.78 µM -0.0221348627770431 0.481852895126473 no 1745 0.491170188404104 2466 5724239
SGTC_2313 7726885 200 µM -0.0230883012883857 0.481524247656507 no 1746 0.49078991870983 2465 726423
SGTC_2978 9011784 42.97 µM -0.0240112134487673 0.481206134487603 no 1747 0.490421832123937 2477 2994934
SGTC_3211 9128781 49.47 µM -0.0252792767500136 0.480769072758444 no 1748 0.489916101703363 2517 17194361
SGTC_2958 9077254 16.72 µM -0.0259405580406029 0.48054115893335 no 1749 0.489652375141183 2494 16457351
SGTC_665 3914-0008 307 µM -0.0262156492953373 0.480446349258615 no 1750 0.489542666919888 2464 1069549
SGTC_2769 toremifene 3.73 µM -0.0263711024994603 0.480392773097975 no 1751 0.489480671497913 2490 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_262 fenpropimorph 62.5 µM -0.0293356494397462 0.479371125883947 no 1752 0.488298447493834 2458 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_3240 9133527 49.47 µM -0.0309133368312375 0.478827475391299 no 1753 0.48766932687689 2458 17617455
SGTC_2070 5230947 200 µM -0.0311339320998442 0.478751464255319 no 1754 0.487581364438176 2455 2835538
SGTC_1024 4507-0395 26 µM -0.0312186185710126 0.478722283803432 no 1755 0.487547595839113 2583 4201836
SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM -0.031821839878753 0.478514434900369 no 1756 0.48730706487509 2472 551469
SGTC_1400 3771-8998 51.5 µM -0.0328350463416329 0.478165332672791 no 1757 0.486903065166464 2483 670767
SGTC_1107 amlodipine 47 µM -0.033383762537051 0.477976278432495 no 1758 0.486684279032039 2489 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.
SGTC_3019 9081971 49.47 µM -0.0334881739473311 0.477940305168405 no 1759 0.48664264818334 2482 16451803
SGTC_989 1501-0895 10.3 µM -0.0337927552526924 0.477835367629712 no 1760 0.486521206559306 2462 2830112
SGTC_2592 piperlongumine 83.33 µM -0.0345998408764516 0.477557309494983 no 1761 0.486199414193702 2506 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_2010 4012422 159 µM -0.0351237933840717 0.477376802570679 no 1762 0.485990514369269 2498 952393
SGTC_246 cycloheximide 667 µM -0.0352527127608299 0.477332389254973 no 1763 0.48593911481081 2467 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells.
SGTC_454 lyso-paf C-16 6.67 µM -0.0365977257024667 0.47686904303127 no 1764 0.485402878471815 2491 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_1070 indatraline 8.81 µM -0.0387073514539377 0.476142357023145 no 1765 0.48456185609538 2494 10314472 A monamine transport inhibitor. YGL099W LSG1
SGTC_3185 9108267 49.47 µM -0.0388809832489175 0.476082550960233 no 1766 0.484492639136156 2503 4910486
SGTC_146 3448-8650 53.125 µM -0.0396611009090483 0.475813852430055 no 1767 0.484181657118728 2518 2891488 YIL048W NEO1
SGTC_1987 st072290 61.9 µM -0.040655489744139 0.475471367724305 no 1768 0.483785273136448 2529 54697379
SGTC_1405 3909-7894 12 µM -0.0410925727456483 0.475320834500805 no 1769 0.483611047847204 2513 7104060
SGTC_2654 protoveratrine a 100 µM -0.0414745913163865 0.475189268583005 no 1770 0.483458774306166 2475 5702278 A heart drug and vasodilator.
SGTC_2477 5967686 25.23 µM -0.0440924152640542 0.474287772311535 no 1771 0.482415369324504 2500 776118
SGTC_61 0978-8327 98.565 µM -0.0442083224975832 0.474247860513464 no 1772 0.482369174073582 2479 6150059 YHR072W ERG7
SGTC_953 1188-0045 9.7 µM -0.0452406210636458 0.473892407590249 no 1773 0.481957758226776 2535 6144426
SGTC_2670 beta-carotene 100 µM -0.0460793344382875 0.473603627438174 no 1774 0.481623508619347 2496 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.)
SGTC_1527 coumarin 137 µM -0.0461598832752399 0.473575894131656 no 1775 0.481591408439653 2662 323 A hepatotoxic, DNA x-linker.
SGTC_1727 st034309 9.9045 µM -0.0462575439968256 0.473542269302399 no 1776 0.481552489022132 2548 870305
SGTC_1193 1488-0126 41.5 µM -0.0476716570491212 0.473055407909302 no 1777 0.480988961405049 2524 1384710
SGTC_2737 bleomycin 30.5 nM -0.0484939398132322 0.472772324723621 no 1778 0.480661297044942 2494 16211318 Bleomycin acts by induction of DNA strand breaks.
SGTC_2791 5663188 71.43 µM -0.0488720256621239 0.472642167600786 no 1779 0.480510641250504 2537 54690634
SGTC_1234 0326-0494 15.5 µM -0.0511694249022547 0.471851344721364 no 1780 0.47959525765461 2572 1547813
SGTC_2868 9035608 32.47 µM -0.0513799455158925 0.47177888370861 no 1781 0.479511382411512 2474 6462614
SGTC_3302 9125395 16.351 µM -0.0531424847182211 0.471172256122743 no 1782 0.478809190673852 2528 17599668
SGTC_991 3996-0057 64.7 µM -0.0547913486453463 0.470604813611854 no 1783 0.478152346415606 2555 715343
SGTC_1610 st001799 48.1 µM -0.0554743613940761 0.470369777992869 no 1784 0.477880277566292 2506 621897
SGTC_1970 st070122 35.8 µM -0.0562965993363448 0.4700868464562 no 1785 0.477552763938462 2570 102928
SGTC_258 haloperidol 50.781 µM -0.0572373377673439 0.469763157510094 no 1786 0.477178067830959 2517 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_2072 5231554 129 µM -0.057724349358321 0.469595594570302 no 1787 0.476984099024084 2545 789545
SGTC_453 enantio-paf c16 10 µM -0.0579344879487003 0.469523295200821 no 1788 0.476900405917845 2519 13871343 A lipid and platelet activating factor
SGTC_2627 acetyl isogambogic acid 100 µM -0.0590174234134617 0.46915072111944 no 1789 0.476469115211549 2571 6857789 A caspase activator and apoptosis inducer.
SGTC_1928 4'-methoxychalcone 40.3 µM -0.0590644945285517 0.469134527341317 no 1790 0.4764503692547 2551 641818
SGTC_507 nimesulide 162 µM -0.0595558113628356 0.468965503682479 no 1791 0.476254706641842 2537 4495 A COX2 inhibitor.
SGTC_2969 9091408 28.7 µM -0.0602210071575801 0.468736670804211 no 1792 0.475989807392336 2554 4286311
SGTC_2137 5261020 140 µM -0.0630111763766237 0.467776942806646 no 1793 0.474878802273291 2529 763655
SGTC_166 k072-0058 166.424 µM -0.0631882292445589 0.46771604860468 no 1794 0.474808308875567 2513 5846229
SGTC_1254 0550-0035 264 µM -0.063562705879098 0.467587256480926 no 1795 0.474659214030732 2583 15121435
SGTC_2239 6685329 187.64 µM -0.0637761118187745 0.467513862219111 no 1796 0.47457424976711 2658 805680
SGTC_333 3486-0131 40.1 µM -0.0640030531026375 0.467435814113049 no 1797 0.474483897885021 2637 6744690
SGTC_965 1291-5240 308 µM -0.0641259656820722 0.467393543375399 no 1798 0.474434963383422 2554 2834598
SGTC_2921 7974240 10.71 µM -0.0642963946559008 0.467334931932364 no 1799 0.474367112082343 2572 2979074 YDR527W RBA50
SGTC_1456 k015-0012 13 µM -0.0644646857048432 0.467277056428169 no 1800 0.474300112662969 2521 2989616
SGTC_1856 st057054 55.7 µM -0.0645460600699947 0.467249071929305 no 1801 0.474267716457722 2565 1266018
SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM -0.064928977857201 0.46711738936147 no 1802 0.474115274137133 2504 279621
SGTC_2948 9070189 9.45 µM -0.064994301644492 0.467094925357726 no 1803 0.474089268646178 2553 6473636 YDL196W YDL196W
SGTC_766 1391-0721 126 µM -0.0653493348455755 0.466972835876289 no 1804 0.473947931366574 2540 1020919 YIL115C NUP159
SGTC_527 4476-4215 268 µM -0.0662218272137902 0.466672814792999 no 1805 0.473600609655779 2561 4418754
SGTC_1327 1436-0082 2.18 µM -0.0670156362476579 0.466399866736015 no 1806 0.473284627629291 2580 15992205
SGTC_260 nsc-65238 3.989 µM -0.0670362121283002 0.46639279201142 no 1807 0.473276437458291 2521 3246252
SGTC_1679 SEC14.276 6.7 µM -0.0670887032444143 0.466374743734081 no 1808 0.473255543569404 2578 1005053 YMR079W SEC14
SGTC_2798 7813637 45.45 µM -0.0671478004201821 0.466354424145672 no 1809 0.473232020251682 2590 956368
SGTC_2378 9074213 121.43 µM -0.067301010927402 0.466301745650245 no 1810 0.473171036055879 2534 657714
SGTC_2982 9019404 25.97 µM -0.0705605886988551 0.465181143688363 no 1811 0.471873738928031 2548 22333232
SGTC_2113 5491891 107.031 µM -0.0705654704405989 0.465179465611594 no 1812 0.471871796237338 2543 789979
SGTC_3209 9113616 49.47 µM -0.0707690669857511 0.465109480766681 no 1813 0.471790775523419 2543 16649353
SGTC_3040 9091894 49.47 µM -0.0709310624615295 0.465053796760379 no 1814 0.471726310680291 2568 25236966
SGTC_366 0181-0206 4.31 µM -0.0711170621753449 0.464989862428502 no 1815 0.47165229445042 2555 274874
SGTC_1908 st060353 56.5 µM -0.0725990704117418 0.464480478982392 no 1816 0.471062583236953 2583 4227716
SGTC_3262 9137218 49.47 µM -0.0727775816120798 0.464419126520745 no 1817 0.470991555460701 2503 17650664
SGTC_2397 5161689 200 µM -0.0738843865080686 0.464038748013073 no 1818 0.470551189825524 2597 2259942
SGTC_2976 9009005 19.48 µM -0.0747653780743092 0.463735998834029 no 1819 0.470200694491683 2551 2993148
SGTC_368 fentichlor 4.58 µM -0.0748723759442357 0.463699230876488 no 1820 0.470158127825578 2594 7329 A pesticide.
SGTC_406 estrone 100 µM -0.077898887609364 0.462659352361952 no 1821 0.46895424214142 2567 5870 A steroid.
SGTC_1600 coumarin 106 71.1 µM -0.0779887288781147 0.462628487683337 no 1822 0.468918509368362 2697 100336 A hepatotoxic, DNA x-linker.
SGTC_628 1636-0253 16 µM -0.0780305783126895 0.462614110521637 no 1823 0.468901864582602 2587 4456143
SGTC_542 3381-0244 89.3 µM -0.0781729432557144 0.462565202130904 no 1824 0.468845242146429 2595 1112843
SGTC_1636 st007707 68.9 µM -0.0797681092503463 0.462017233883405 no 1825 0.468210844302892 2592 403051
SGTC_384 k007-0144 5.16 µM -0.0800960829658666 0.461904577905816 no 1826 0.468080419040346 2611 6824886
SGTC_1181 1222-0449 220 µM -0.0817340566051274 0.461341994838438 no 1827 0.467429097848678 2643 658318
SGTC_2398 5228213 48.84 µM -0.0825630741148782 0.461057287546662 no 1828 0.467099481789065 2569 80771 YMR134W ERG29
SGTC_1564 D-Arginine 115 µM -0.0842814356638071 0.460467218908669 no 1829 0.466416336037216 2585 71070 D-isomer of arginine; arginine decarboxylase inhibitor.
SGTC_1836 st055642 81 µM -0.0845383245932356 0.460379013197053 no 1830 0.466314216632776 2558 8571
SGTC_672 1441-0018 53.7 µM -0.0848409626028424 0.460275101524404 no 1831 0.466193913736435 2561 251141
SGTC_1606 st000094 49.2 µM -0.0849038287797242 0.460253516573189 no 1832 0.466168923927591 2545 1242210
SGTC_940 3232-1287 54.8 µM -0.0853811531992932 0.460089632202682 no 1833 0.465979188005798 2541 1585493 YIL048W NEO1
SGTC_376 3970-0862 59.1 µM -0.088610497891192 0.458981049818675 no 1834 0.464695732398366 2629 3135186
SGTC_2188 6126565 140.678 µM -0.0886426328019448 0.458970020006009 no 1835 0.464682962673375 2573 874518
SGTC_2874 9043904 71.43 µM -0.0891960969933438 0.4587800569194 no 1836 0.464463033581969 2641 4463428
SGTC_2265 7929201 200 µM -0.0899871592108338 0.458508560456152 no 1837 0.464148709446373 2542 1265108
SGTC_882 0843-0131 351 µM -0.0903863116330194 0.458371576710655 no 1838 0.463990116950858 2558 5425421
SGTC_2757 clomiphene 4.22 µM -0.0912464673311328 0.45807639966497 no 1839 0.463648376666845 2627 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined.
SGTC_3024 9090631 49.47 µM -0.091419669095232 0.458016965327332 no 1840 0.463579566756361 2554 25236383
SGTC_1834 st055981 52.8 µM -0.0919484725640346 0.457835511765821 no 1841 0.463369489506596 2725 471719 YDL150W RPC53
SGTC_1529 apigenin 74 µM -0.0929358948523053 0.4574967113494 no 1842 0.462977244584437 2630 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_423 5-fluorouracil 457 µM -0.0948726995064742 0.456832252554745 no 1843 0.462207970662085 2557 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM -0.100335068829496 0.454958935798717 no 1844 0.460039158528302 2595 689007
SGTC_67 0335-0847 266 µM -0.100380691432167 0.454943293708767 no 1845 0.46002104916922 2943 4552207 YOR254C SEC63
SGTC_2380 9035439 200 µM -0.101215473245626 0.454657094157911 no 1846 0.459689706961725 2712 6462575
SGTC_261 5-fluorouridine 15.376 µM -0.102290710484965 0.454288490721521 no 1847 0.45926296429512 2625 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_2271 7849410 118.62 µM -0.10295492465087 0.454060810272913 no 1848 0.45899937284587 2557 972430
SGTC_3130 9127414 49.47 µM -0.103206380964548 0.453974619589998 no 1849 0.458899587840515 2569 1494646
SGTC_2729 fluphenazine 10.66 µM -0.103377534537958 0.453915955198228 no 1850 0.458831670723461 2603 3372 An atypical antipsychotic.
SGTC_860 0443-0016 25.1 µM -0.105375608848697 0.453231172380287 no 1851 0.458038884806662 2607 5337942
SGTC_2967 9089538 49.85 µM -0.105653640636436 0.453135895911941 no 1852 0.457928581903432 2652 728216
SGTC_2017 5132927 60.65 µM -0.105937340306978 0.453038679943384 no 1853 0.457816033734184 2617 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis
SGTC_22 0964-0034 14.468 µM -0.106284913281259 0.452919580211221 no 1854 0.457678150621447 2629 138402
SGTC_2767 sibutramine 71.45 µM -0.107114606871564 0.45263529364766 no 1855 0.457349029615174 2669 64765 A serotonin-norepinephrine reuptake inhibitor.
SGTC_2294 7971431 200 µM -0.107419123169795 0.452530960136919 no 1856 0.45722824209346 2685 5741572
SGTC_2450 5739737 12.93 µM -0.107867048465493 0.452377497729351 no 1857 0.45705057804311 2659 2262825
SGTC_3069 9117009 49.47 µM -0.108425353866887 0.452186228271065 no 1858 0.456829145105139 2598 41904981
SGTC_2019 4016004 108 µM -0.109673373731871 0.451758710206446 no 1859 0.456334208844915 2664 45595336
SGTC_2103 5378138 10 µM -0.109992413594576 0.451649429794655 no 1860 0.456207695741542 2597 244142
SGTC_2877 9040724 71.43 µM -0.110538292000072 0.451462459100603 no 1861 0.45599124164908 2625 6463895
SGTC_623 k072-0108 16.9 µM -0.110980379673266 0.45131104601676 no 1862 0.455815952680425 2682 5382803
SGTC_2451 5856223 45.7 µM -0.111178274528657 0.451243270192917 no 1863 0.45573748961476 2642 2179896
SGTC_2166 5933061 31.504 µM -0.111779182560828 0.451037477518527 no 1864 0.455499246987507 3037 2877375
SGTC_3327 9140648 26.9345 µM -0.111914535723503 0.450991125002376 no 1865 0.455445585584627 2629 8029710
SGTC_3283 9109332 35.8195 µM -0.113687935564574 0.45038387538418 no 1866 0.45474258826758 2585 17027281
SGTC_826 1683-5028 118 µM -0.114252814269713 0.45019047328686 no 1867 0.454518693118586 2680 722377
SGTC_3244 9134489 49.47 µM -0.114530611049556 0.450095366089416 no 1868 0.454408590968692 2681 16584271
SGTC_3269 9137823 49.47 µM -0.114703427403438 0.45003620169781 no 1869 0.45434009859354 2594 17682936
SGTC_1474 0330-0125 5.35 µM -0.116083255154393 0.449563851914101 no 1870 0.45379327977002 2648 X1474
SGTC_836 0330-0104 1.35 µM -0.117572265971455 0.449054206197414 no 1871 0.453203290523698 2625 46494820
SGTC_1495 4469-0029 237 µM -0.117779328910391 0.448983341126582 no 1872 0.453121254335593 2608 793680
SGTC_1759 st043059 70 µM -0.118422961131203 0.448763075301334 no 1873 0.452866266717667 2641 669426
SGTC_1961 st076550 68.7 µM -0.118443603459495 0.448756011280384 no 1874 0.452858089172656 2733 1579337
SGTC_624 k048-0052 28 µM -0.119303081114097 0.448461903471143 no 1875 0.452517621279796 2675 6835531
SGTC_3137 9097352 49.47 µM -0.12108420436001 0.447852504724666 no 1876 0.451812170105305 2856 44120435
SGTC_132 0417-1715 25.805 µM -0.122489072088767 0.447371925885987 no 1877 0.451255850016851 2651 6769098
SGTC_290 2043-6722 48.1 µM -0.124133237837443 0.44680958585758 no 1878 0.450604890843628 2680 773758 YLR208W SEC13
SGTC_489 paxilline 115 µM -0.125051741247857 0.446495484429879 no 1879 0.450241294100257 2683 105008 A toxic potassium channel blocker.
SGTC_1357 1503-1303 39.5 µM -0.125177747776782 0.446452396479087 no 1880 0.450191416683068 2646 292895
SGTC_2558 carylophyllene oxide 100 µM -0.125244715236879 0.446429497203675 no 1881 0.450164909139072 2609 6708694 An oxygenated terpenoid and antifungal agent.
SGTC_1662 st014054 52 µM -0.125561232733942 0.446321267634543 no 1882 0.450039625906739 2603 2838777
SGTC_515 4092-1064 102 µM -0.126049557563006 0.446154298342937 no 1883 0.449846348059617 2731 717353
SGTC_861 0443-0273 110 µM -0.126815308574909 0.445892490006971 no 1884 0.44954328953729 2717 6149169
SGTC_39 0986-0283 58.349 µM -0.12705665227679 0.445809980088865 no 1885 0.449447779899732 2700 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2
SGTC_2744 captopril 92.04 µM -0.127166759496508 0.4457723377161 no 1886 0.449404206912947 2662 44093 angiotensin-converting enzyme (ACE) inhibitor
SGTC_1780 st038448 24.544 µM -0.12791792792841 0.445515548703957 no 1887 0.449106961583651 2836 728868 YDL195W SEC31
SGTC_646 4092-0839 27.3 µM -0.128515986251933 0.445311117144584 no 1888 0.448870323964403 2737 877796
SGTC_3182 9108849 49.47 µM -0.131776393245037 0.444196884169276 no 1889 0.447580579578709 2707 17133045
SGTC_2322 7413319 38.22 µM -0.131856558252534 0.444169493568973 no 1890 0.447548875010468 2747 1840400
SGTC_1738 st035555 74 µM -0.133496283459043 0.443609294624552 no 1891 0.446900451667438 2737 5331140
SGTC_2141 5621638 7.665 µM -0.133761445572792 0.443518714672687 no 1892 0.446795607564162 2763 2856238
SGTC_2292 7671323 168.05 µM -0.133798483670705 0.443506062613074 no 1893 0.44678096313526 2761 937504
SGTC_2347 9049783 174.81 µM -0.135355840459758 0.442974128313125 no 1894 0.446165268475469 2754 6467988 YPL169C MEX67
SGTC_920 mycophenolic acid 780.421 nM -0.136307354709609 0.442649177471811 no 1895 0.445789154967347 2690 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_1030 k029-0042 36.7 µM -0.136421313107566 0.442610262216466 no 1896 0.445744112881124 2695 6080581
SGTC_906 1165-0455 526 µM -0.139015357964343 0.441724581379138 no 1897 0.444719006493487 2638 3252859
SGTC_2848 9016370 25.97 µM -0.139733732083496 0.441479359297379 no 1898 0.444435186757421 2666 7894410
SGTC_1202 1988-0068 29.6 µM -0.14086077987627 0.441094678805727 no 1899 0.443989963136394 2661 2850480
SGTC_2436 5633522 8.09 µM -0.141963786884181 0.440718257641586 no 1900 0.443554304900689 2706 5724242
SGTC_1361 1608-0041 5.61 µM -0.142763640670372 0.440445326499152 no 1901 0.443238426708702 2666 X1361
SGTC_1902 st060212 70.5 µM -0.142783779949495 0.440438454812196 no 1902 0.44323047377091 2652 688944
SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM -0.144058713540599 0.44000347362864 no 1903 0.442727053200771 2658 364106
SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM -0.145403440192213 0.439544758954242 no 1904 0.44219617432512 2622 5711223 A potent inhibitor of glutathione S-transferases.
SGTC_985 1493-0307 8.71 µM -0.147061992196207 0.438979103661567 no 1905 0.441541544734662 2726 3278274
SGTC_734 2023-0417 80 µM -0.147202435434419 0.438931210681841 no 1906 0.441486119170711 2786 3935732
SGTC_2105 5350118 200 µM -0.147990531218835 0.438662476324244 no 1907 0.441175120475461 2713 2133313
SGTC_446 go6976 132 µM -0.148648442194205 0.438438155594598 no 1908 0.440915523134883 2766 3501 A protein kinase C inhibitor.
SGTC_1152 3909-8331 15.9 µM -0.148909534924624 0.438349139131352 no 1909 0.440812508660795 2668 16001939
SGTC_2818 7996756 12.99 µM -0.149578215789873 0.438121174571295 no 1910 0.440548698041331 2659 2241621
SGTC_3110 9122132 49.47 µM -0.152616694937155 0.437085565625424 no 1911 0.439350279290606 2818 918317
SGTC_2761 levamisole 97.89 µM -0.152995575779133 0.43695646123132 no 1912 0.439200882116437 2753 26879 An alkaline phosphatase inhibitor.
SGTC_396 dithiazanine 1.25 µM -0.156327620211575 0.435821351183224 no 1913 0.437887393097977 2710 10578 An antihelmenthic.
SGTC_3050 9093513 49.47 µM -0.156639042242373 0.435715287539531 no 1914 0.437764665536567 2698 25236664
SGTC_2496 diffractaic acid 79.83 µM -0.156721336032041 0.435687260817279 no 1915 0.437732235573844 2931 94870 An apoptosis inducer which activates caspases.
SGTC_2517 totarol 10 µM -0.158430051785433 0.435105398209639 no 1916 0.437058967454595 2749 460178 An antibacterial membrane disruptor. YGL001C ERG26
SGTC_172 1112-0046 2.638 µM -0.159455016196772 0.434756438231249 no 1917 0.436655198334416 2750 2802135 YIL048W NEO1
SGTC_643 k048-0106 28.4 µM -0.160816802792061 0.43429288223298 no 1918 0.436118845388059 2801 6763920
SGTC_2873 9040596 71.43 µM -0.16084802394678 0.434282255520685 no 1919 0.436106550004947 2803 6463863
SGTC_1664 st014217 9.02 µM -0.161380475344355 0.434101032903526 no 1920 0.435896871762727 2695 3982782
SGTC_2909 7941780 10.49 µM -0.161382098990441 0.434100480308252 no 1921 0.435896232401831 2705 1243215
SGTC_2799 7812892 81.82 µM -0.161525624273276 0.434051633107307 no 1922 0.435839715541989 2827 20205235
SGTC_408 cantharidin 100 µM -0.164895907314109 0.432904886567686 no 1923 0.434512956897425 2748 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_1288 0973-0013 65.5 µM -0.165420338519828 0.432726498182691 no 1924 0.43430657318652 2791 4315430
SGTC_1443 4112-3303 14 µM -0.167795821056377 0.431918635930756 no 1925 0.433371955100971 2713 704433
SGTC_2851 9015922 71.43 µM -0.167954582581166 0.431864653876089 no 1926 0.433309504637607 2869 2996893
SGTC_2179 6298986 200 µM -0.168134069640354 0.43180362626255 no 1927 0.433238903579665 2811 738374
SGTC_458 nppb 133 µM -0.16954548845047 0.431323784866862 no 1928 0.432683797807306 2848 4549 A chloride channel blocker.
SGTC_1751 st044839 27.194 µM -0.16966415489786 0.431283446330187 no 1929 0.432637132772597 2670 5291326
SGTC_3162 9099653 49.47 µM -0.16978475264247 0.431242452017866 no 1930 0.43258970922672 2715 25237511
SGTC_2482 5981709 142.65 µM -0.170764437587388 0.430909459091425 no 1931 0.432204496490115 2789 877755
SGTC_2975 9084847 53.72 µM -0.171059575317183 0.430809151990831 no 1932 0.432088460763199 2814 27211724
SGTC_896 0964-0007 44.5 µM -0.1713059334351 0.430725426809753 no 1933 0.431991607610872 2669 6756758
SGTC_1611 st001856 99.4 µM -0.172190385746493 0.43042487002729 no 1934 0.431643928028176 2738 647478
SGTC_541 4513-1321 94 µM -0.172775284666404 0.430226130350693 no 1935 0.43141403241858 2732 747515
SGTC_2690 usnic acid 100 µM -0.175555677745116 0.429281638000122 no 1936 0.430321512740319 2902 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_2813 7971799 71.43 µM -0.175580544724606 0.429273192569364 no 1937 0.430311743974013 2838 2234054
SGTC_1612 st002233 45.4 µM -0.17676178572546 0.42887205177132 no 1938 0.429847753449278 2711 1035021
SGTC_130 0136-0219 337.655 µM -0.177585763374247 0.428592278459787 no 1939 0.429524153000995 2696 234244
SGTC_1997 st073024 93.8 µM -0.178551198507073 0.428264520342782 no 1940 0.429145058259353 2734 686268
SGTC_21 0849-0113 22.993 µM -0.179214554960334 0.42803934437735 no 1941 0.428884617769337 2730 1560156
SGTC_1745 st081495 74 µM -0.179272260098434 0.42801975750826 no 1942 0.428861963607397 2739 13842402 YBL026W LSM2
SGTC_1717 st033143 58.0435 µM -0.180156281597972 0.427719716073678 no 1943 0.428514939514749 2858 674616
SGTC_1626 st003712 1.76 µM -0.181474629090452 0.427272339856591 no 1944 0.427997522779585 2878 24207035
SGTC_571 k831-0106 44.2 µM -0.184854667641918 0.426125765151533 no 1945 0.426671514046575 2769 4783639
SGTC_728 3030-5151 22.5 µM -0.185721353369207 0.425831868683209 no 1946 0.426331641038806 2720 3125388
SGTC_960 1222-0186 7.7 µM -0.187536548547627 0.425216462686268 no 1947 0.425619985195181 2839 3126296
SGTC_3235 9132602 49.47 µM -0.188454953394295 0.424905165009715 no 1948 0.42526001237304 2828 4912240
SGTC_337 1315-0038 354 µM -0.189273311690802 0.424627818028982 no 1949 0.424939305715592 2752 1626437
SGTC_2238 6671620 73.2395 µM -0.189817946914448 0.424443258258497 no 1950 0.424725895984463 2691 729941
SGTC_2208 7283366 200 µM -0.190349776245584 0.42426305398787 no 1951 0.424517525400114 2775 898663
SGTC_1889 st059080 5.18 µM -0.190575841825134 0.424186459051465 no 1952 0.42442895935412 2742 176925 Isolated from Daphnopsis sellowiana.
SGTC_1191 1487-1166 10.6 µM -0.191105120710412 0.424007141396892 no 1953 0.424221617915322 2866 3955771
SGTC_2207 7258803 200 µM -0.191216160786136 0.423969523440764 no 1954 0.424178121372929 2828 3666799
SGTC_2181 6316240 54.2555 µM -0.191780992127731 0.423778181631568 no 1955 0.423956880334735 2825 12779990
SGTC_380 3970-0968 6 µM -0.191807367089898 0.423769247309471 no 1956 0.42394655000585 2756 2891601
SGTC_549 1661-1316 519 µM -0.192402374132837 0.423567703524939 no 1957 0.423713516427964 2839 2857282
SGTC_1779 st039427 55 µM -0.193013974093591 0.423360560142556 no 1958 0.423474012063124 2761 1124498
SGTC_3190 9110366 49.47 µM -0.193133051436298 0.423320232183797 no 1959 0.423427384306651 2822 17123768
SGTC_3350 9150499 3.57 µM -0.193596963197505 0.423163126715831 no 1960 0.423245738112034 2734 4910996 YPR165W RHO1
SGTC_3289 9119912 71.43 µM -0.194233297653688 0.422947649528667 no 1961 0.422996605779495 2857 17014829
SGTC_2923 7992654 58.14 µM -0.194324472616111 0.422916777518063 no 1962 0.422960912242051 2788 2985126
SGTC_1688 st021091 57.6 µM -0.196234579868228 0.422270120798002 no 1963 0.422213281686484 2755 3656366
SGTC_3132 9126706 49.47 µM -0.196239346819711 0.422268507233074 no 1964 0.422211416214692 2963 850858
SGTC_155 k072-0202 43.6 µM -0.196467545519942 0.422191265804516 no 1965 0.422122116270006 2710 5857737
SGTC_895 0964-0006 13.7 µM -0.199018361361347 0.421328061821064 no 1966 0.421124190800912 2755 6738897
SGTC_1737 st035557 69.7 µM -0.200902639750642 0.420690658665736 no 1967 0.420387351787661 2697 5716916
SGTC_2193 5925765 200 µM -0.200938046936274 0.420678683305582 no 1968 0.420373508620597 2885 877370
SGTC_1753 st043925 64 µM -0.201609733115597 0.420451520626624 no 1969 0.420110917776281 2856 670181
SGTC_342 k048-0088 23.3 µM -0.201694034281718 0.420423012040916 no 1970 0.420077963355335 2727 6820570
SGTC_111 0083-0039 52.457 µM -0.203220828118912 0.419906760215957 no 1971 0.419481217003169 2742 759313
SGTC_641 4092-0595 30 µM -0.203628325379517 0.419768997220499 no 1972 0.419321978214497 2815 786260
SGTC_2588 indole-3-carbinol 100 µM -0.204609735117834 0.419437251458612 no 1973 0.418938524398629 2907 3712 Induces cell cycle arrest.
SGTC_1141 3253-0389 52.6 µM -0.206099945650734 0.418933625402942 no 1974 0.418356420612138 2760 5402031
SGTC_245 methotrexate 289.6 µM -0.206878371129776 0.418670604355436 no 1975 0.418052424224284 2840 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2
SGTC_1763 st044482 94.5 µM -0.207157047598436 0.418576451601575 no 1976 0.417943605350014 2913 88505
SGTC_958 1222-0007 33 µM -0.208657850407584 0.418069475425316 no 1977 0.417357673155804 2941 7312461
SGTC_464 bw-b 70c 158 µM -0.20901968661038 0.417947266284864 no 1978 0.417216435174693 2914 5353454
SGTC_1226 3909-7979 35.4 µM -0.209728646686156 0.417707840030786 no 1979 0.41693973296012 2894 6615510
SGTC_2916 7875993 68.79 µM -0.212615413214517 0.416733252337571 no 1980 0.415813474153459 2796 1299250
SGTC_1402 3909-7673 35.9 µM -0.21418920716882 0.416202146226182 no 1981 0.415199756110088 2747 5328014
SGTC_1063 disulfiram 1.84 µM -0.214354103312265 0.416146507785521 no 1982 0.415135465014674 2778 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_2371 9071574 200 µM -0.214472945077306 0.416106409827189 no 1983 0.41508913139663 2866 45596039
SGTC_2231 micatex 6.853 µM -0.216968775085087 0.415264503462622 no 1984 0.41411633958301 2816 20737 An antifungal of unknown mechanism.
SGTC_780 0109-0199 192 µM -0.217045620763939 0.415238587630388 no 1985 0.414086396011983 2973 610414
SGTC_1356 1502-0781 85.8 µM -0.217404169759587 0.41511767359798 no 1986 0.413946690956561 2777 567702
SGTC_1555 citronellol 128 µM -0.217965042366621 0.414928545789316 no 1987 0.41372817436223 2853 8842 A terpine precursor.
SGTC_3041 9091929 49.47 µM -0.218158466590603 0.414863327170686 no 1988 0.413652822259612 2953 25236887
SGTC_634 1611-4317 11.2 µM -0.21929317738804 0.414480773645067 no 1989 0.413210838111896 2772 2843522
SGTC_1015 4130-4525 82 µM -0.21960672283455 0.414375080013624 no 1990 0.413088727579586 2812 1363237
SGTC_1283 0922-0125 16.4 µM -0.219618962177193 0.414370954355997 no 1991 0.413083961127948 2904 3360884
SGTC_193 1273-0060 1.558 µM -0.219756638056693 0.414324546996417 no 1992 0.413030345943246 2779 2847393 YHR072W ERG7
SGTC_432 NS 1619 61.3 µM -0.22019533289982 0.41417668107634 no 1993 0.412859515621176 2958 4552 A K+/calcium channel activator.
SGTC_142 0335-0849 62.6745 µM -0.220819959867473 0.413966166108404 no 1994 0.412616310730382 2816 3889043 YPR107C YTH1
SGTC_1907 st060210 83.7 µM -0.221949878342169 0.413585418060265 no 1995 0.412176450711311 2975 688793
SGTC_207 4185-0010 4.486 µM -0.222618953776932 0.413359998325551 no 1996 0.411916041813504 2863 3761753
SGTC_3215 9129942 49.47 µM -0.223283829645876 0.413136021763295 no 1997 0.411657305836553 2897 17682944
SGTC_2930 9013230 14.89 µM -0.223956415719387 0.412909476629064 no 1998 0.411395608518087 2938 2995857
SGTC_1144 3486-0183 12.5 µM -0.22580507696469 0.412286947272415 no 1999 0.410676514104483 2809 6744069
SGTC_1809 st050081 57.6 µM -0.227343392832424 0.411769093594469 no 2000 0.410078366869546 2968 5036894
SGTC_3081 9117243 49.47 µM -0.231030349606387 0.41052855539804 no 2001 0.408645612084147 3001 45595589
SGTC_3332 9141069 11.198 µM -0.231369417979667 0.410414514910628 no 2002 0.408513910775238 2796 17332883
SGTC_169 k015-0017 16.025 µM -0.231664402111264 0.410315307647888 no 2003 0.408399341119253 3010 1840002
SGTC_1266 0828-0227 32.9 µM -0.231735337820501 0.410291451838837 no 2004 0.408371791381549 2932 3913820
SGTC_1714 st033236 13.627 µM -0.231839378110608 0.410256463499053 no 2005 0.408331385433393 2976 2916566
SGTC_811 0416-0114 265 µM -0.231877376175157 0.410243685077686 no 2006 0.408316628433507 2900 6612453
SGTC_3265 9137266 49.47 µM -0.233192747786303 0.409801395790026 no 2007 0.407805868531963 2824 17224265
SGTC_3075 9116269 49.47 µM -0.234893457877012 0.409229707898175 no 2008 0.407145713694886 3023 17015205 YNL244C SUI1
SGTC_863 0466-0191 129 µM -0.235359345258532 0.409073135070321 no 2009 0.406964918805615 2933 765160 YPR165W RHO1
SGTC_1000 4048-0884 8.67 µM -0.236645064723477 0.408641112987608 no 2010 0.40646607820009 2955 13040088
SGTC_913 3487-1245 167 µM -0.23706216666412 0.408500983954781 no 2011 0.406304281227082 2789 4016153
SGTC_2223 6903751 107.57 µM -0.241666120759376 0.406955026451073 no 2012 0.404519441615471 2927 5598863
SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM -0.242780297474341 0.406581114872749 no 2013 0.404087799669622 2930 5379071
SGTC_1345 1488-0192 31.4 µM -0.245784534227263 0.405573334826259 no 2014 0.402924514893231 2975 658348
SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM -0.245818652024564 0.405561893491066 no 2015 0.402911308891296 2886 676296 Flavone; oxidizing agent.
SGTC_1209 2323-2347 50.3 µM -0.247095871466547 0.405133638631476 no 2016 0.402417014390462 2847 5412760
SGTC_513 4245-1575 41.7 µM -0.247470119642268 0.405008173778238 no 2017 0.402272206760718 2961 719745
SGTC_2364 9055074 200 µM -0.252056752419638 0.403471324599428 no 2018 0.400498598719601 2942 6470630
SGTC_1709 st033179 39.1045 µM -0.252319062269834 0.403383476890053 no 2019 0.400397227569679 2855 573381
SGTC_932 2857-0803 154 µM -0.254262013832961 0.402732933440589 no 2020 0.39964657209475 3084 674898
SGTC_2800 7887935 81.82 µM -0.254446388237234 0.402671214741664 no 2021 0.399575358628611 3045 2961002
SGTC_2993 9054257 71.4286 µM -0.25586089293074 0.402197794945067 no 2022 0.399029126293412 2836 6470217 YGL055W OLE1
SGTC_937 3122-0005 46.7 µM -0.257167930077086 0.401760470883091 no 2023 0.398524569850253 3019 759535
SGTC_502 l-744,832 89.3 µM -0.258644708554085 0.401266500751703 no 2024 0.397954692115857 2981 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.
SGTC_2962 9082311 13.18 µM -0.260142792157206 0.400765565425653 no 2025 0.39737681526044 2844 16459453
SGTC_312 4092-0653 6.84 µM -0.262299705531937 0.400044614628124 no 2026 0.396545194515683 2969 1148278
SGTC_269 exalamide 29 µM -0.262577460889891 0.399951799276307 no 2027 0.396438137111562 2883 3316 A derivative of salicylamide.
SGTC_3295 9122362 53.5725 µM -0.263481272682988 0.399649818648563 no 2028 0.396089827993266 2975 4730473
SGTC_2094 5332512 191.667 µM -0.264053547914749 0.399458641681602 no 2029 0.395869328613774 3018 755774
SGTC_2278 7948257 134.34 µM -0.264471968289509 0.399318877447787 no 2030 0.395708131058242 3030 1247028
SGTC_345 1362-0200 395 µM -0.267330311521904 0.398364456041628 no 2031 0.394607425258749 2892 1419823
SGTC_1641 st009299 47.1 µM -0.271087791108751 0.397110731751942 no 2032 0.393161755703203 2906 4046054
SGTC_3259 9138485 49.47 µM -0.27122375899786 0.39706538441598 no 2033 0.393109470286791 3181 17646153
SGTC_3014 9081533 49.47 µM -0.271511654092423 0.396969371665591 no 2034 0.392998768784959 3045 21367265
SGTC_178 4092-0806 87.505 µM -0.273173762151331 0.396415182418919 no 2035 0.392359823978623 2966 2169044
SGTC_2074 5212007 75.395 µM -0.273877817949967 0.396180495263492 no 2036 0.392089259380128 2968 758611
SGTC_125 0133-0007 11.75 µM -0.275158241033766 0.395753780609146 no 2037 0.391597333937374 3024 26541
SGTC_1872 amphotericin b 148 nM -0.277368417783491 0.395017509794647 no 2038 0.39074861478472 3025 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1
SGTC_452 diindolylmethane 8 µM -0.279196298238371 0.394408875375227 no 2039 0.390047092156328 3011 3071 Inhibits expression of several cancer promoting factors.
SGTC_843 0310-0051 143 µM -0.281593726614795 0.393610987854925 no 2040 0.389127525533719 2941 2065037
SGTC_409 arachidonic acid 100 µM -0.281600097480718 0.393608868162056 no 2041 0.389125082725091 2921 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes.
SGTC_2200 6600604 21.907 µM -0.285054294110267 0.392460065443958 no 2042 0.387801272959263 2901 2904777
SGTC_2913 7966556 36.57 µM -0.286574712031599 0.391954698420412 no 2043 0.387218989753303 3021 2976516
SGTC_6 0844-0013 19.835 µM -0.286631528203767 0.391935816994992 no 2044 0.387197235445477 2982 1584900
SGTC_2159 5658611 73.75 µM -0.290245730529309 0.390735252589478 no 2045 0.385814126643219 3014 793844
SGTC_1114 scopoletin 1.73284 µM -0.29043568524068 0.390672182193002 no 2046 0.385741473381551 3053 5280460 A coumarin with genotoxic properties.
SGTC_580 1123-0028 41 µM -0.290499719854793 0.390650921518001 no 2047 0.38571698253332 2895 1677248 YPR107C YTH1
SGTC_2745 rifampicin 24.3 µM -0.29297697785802 0.389828677625602 no 2048 0.384769874482791 2977 25141428 Inhibits bacterial DNA-dependent RNA polymerase.
SGTC_1415 3966-0071 78.1 µM -0.294464201838257 0.389335279279877 no 2049 0.384201607100837 2960 2893185
SGTC_2507 purpurin 79.67 µM -0.294546197788894 0.38930808165386 no 2050 0.384170283724277 2904 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1
SGTC_76 0433-0009 400.328 µM -0.294664084175016 0.389268980309212 no 2051 0.384125251122882 3039 2841569
SGTC_2140 5586273 200 µM -0.295106042076159 0.389122398742136 no 2052 0.383956437127392 2919 854421
SGTC_1121 fusaric acid 630.51 nM -0.295150455957255 0.389107669124644 no 2053 0.383939473640863 2939 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler.
SGTC_2365 9042475 200 µM -0.295572238657006 0.38896779517596 no 2054 0.383778388580742 3050 6464479
SGTC_51 1013-0126 23.419 µM -0.296297118174624 0.388727440183275 no 2055 0.383501593282266 3203 1627850
SGTC_1108 betulinic acid 729.144 nM -0.2968736869245 0.388536292366274 no 2056 0.383281472899704 2968 64945 Apoptosis-inducing agent of unknown mechanism.
SGTC_2192 5915882 198.485 µM -0.297346568285374 0.388379539808302 no 2057 0.383100966040407 2908 2876149
SGTC_1903 st060211 78.3 µM -0.298808530283448 0.38789503802229 no 2058 0.382543070958291 3099 688960
SGTC_2049 5262831 67.185 µM -0.300510566649472 0.387331194179047 no 2059 0.381893868832585 3008 763417
SGTC_545 4218-0007 221 µM -0.301204939464983 0.387101233282713 no 2060 0.38162911174125 3051 2840508
SGTC_13 0199-0087 65 µM -0.302792383924193 0.386575655782164 no 2061 0.381024043940341 2928 4589825
SGTC_3308 9128332 17.569 µM -0.303555445017411 0.386323092400949 no 2062 0.380733300179774 3109 17332805 YDL196W YDL196W
SGTC_3103 9120822 49.47 µM -0.304896790920673 0.385879240992643 no 2063 0.38022237997262 3168 17141819
SGTC_1650 st011916 45.8 µM -0.305061391925533 0.385824784791142 no 2064 0.380159697633467 3071 242528
SGTC_726 3448-4391 34.2 µM -0.305251337729929 0.385761946373373 no 2065 0.380087367555892 3129 1356692
SGTC_746 1095-0025 46.6 µM -0.305291962758562 0.385748507073551 no 2066 0.380071898364064 3128 6749286
SGTC_1502 4534-4282 27.7 µM -0.305567042254919 0.385657510726372 no 2067 0.379967158686857 2966 3278949
SGTC_1722 st034304 3.6505 µM -0.306846068819053 0.385234491233114 no 2068 0.379480270379461 2954 4036148 YLR033W RSC58
SGTC_1824 st053723 68.6 µM -0.309089910091661 0.384492703374294 no 2069 0.378626567116925 3016 675225
SGTC_1125 tnp00248 1.32998 µM -0.309373736007423 0.384398903886775 no 2070 0.378518623353647 3112 24207736
SGTC_658 3253-0951 102 µM -0.310098298656986 0.384159479344956 no 2071 0.37824310300748 2995 1184878
SGTC_2376 9072922 81.32 µM -0.310115748396432 0.384153713796275 no 2072 0.37823646837682 3069 17087968
SGTC_3062 9077494 49.47 µM -0.310228812445787 0.384116357052775 no 2073 0.378193480742038 3074 16459633
SGTC_3089 9117425 49.47 µM -0.311311631547283 0.383758644539859 no 2074 0.377781862815777 3008 9401657
SGTC_3344 9148862 3.898 µM -0.312095741792196 0.383499673188753 no 2075 0.377483881293589 3122 4905352
SGTC_307 1501-1223 22.3 µM -0.312309609356019 0.383429047286628 no 2076 0.377402618914098 3044 2830329
SGTC_978 1416-0512 87.4 µM -0.312572808507379 0.383342135835081 no 2077 0.377302619664214 3024 6814003
SGTC_2662 daunorubicin 22.37 µM -0.312839722266422 0.383254003771772 no 2078 0.377201217496752 2942 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_842 0271-0008 11.1 µM -0.313206860634113 0.38313278848786 no 2079 0.37706175322222 3082 1221709
SGTC_123 0083-0120 66.675 µM -0.313812335784102 0.382932908359872 no 2080 0.376831787367398 2977 16001701
SGTC_3100 9120536 49.47 µM -0.315260011608776 0.382455126460062 no 2081 0.376282122062897 2903 16421196
SGTC_1177 0983-0204 23.6 µM -0.315365629797448 0.382420275884461 no 2082 0.376242029895976 3115 766818
SGTC_1203 3992-3522 103 µM -0.315729120716902 0.382300342954346 no 2083 0.376104060663861 3297 5322312
SGTC_42 0133-0086 60.653 µM -0.317677267239268 0.381657749507922 no 2084 0.375364878370557 2902 162923 Model of phenazepam hydroxylation.
SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM -0.318289759007455 0.381455787217496 no 2085 0.375132575917853 2948 91467 include heat shock
SGTC_2461 5755302 26.15 µM -0.318798331166767 0.381288115774218 no 2086 0.374939721920076 3112 2788904
SGTC_1409 3909-8004 61.9 µM -0.319363309534688 0.381101873861209 no 2087 0.374725514968011 3007 2119279
SGTC_1060 3448-7350 82 µM -0.320690455421549 0.380664496137065 no 2088 0.374222490524782 3100 570178
SGTC_2297 7971671 152.32 µM -0.320696227335644 0.380662594262338 no 2089 0.374220303279009 3155 909016
SGTC_2176 5809774 33.9695 µM -0.321031932958362 0.380551982534273 no 2090 0.374093095826677 3092 2870539
SGTC_2927 9011802 47.9 µM -0.321934171862916 0.380254752025673 no 2091 0.373751282381667 3071 43912568
SGTC_201 4262-0159 12.803 µM -0.322446795169155 0.380085906634305 no 2092 0.373557119115608 3030 1341029
SGTC_2520 obtusaquinone 4.71 µM -0.322581106176334 0.380041671699454 no 2093 0.373506252241834 3121 5967872
SGTC_1279 0874-0590 65.2 µM -0.323091494980048 0.379873590965567 no 2094 0.373312975585678 3021 3523074
SGTC_2809 7964133 12.99 µM -0.3241782883856 0.379515764874153 no 2095 0.372901529307269 3010 1253665
SGTC_1863 st057641 20.1 µM -0.325553408437275 0.379063155289318 no 2096 0.37238113396142 3014 3921635
SGTC_732 3970-1727 52.7 µM -0.326123159154569 0.378875675002643 no 2097 0.372165587800977 3091 1275699
SGTC_1334 1486-0610 236 µM -0.326335449387205 0.378805826765058 no 2098 0.372085285116907 3060 3742339
SGTC_2686 alizarin 95.37 µM -0.327397228503818 0.378456537120057 no 2099 0.371683731199172 3029 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1
SGTC_675 1309-0189 238 µM -0.327477011645439 0.378430295154728 no 2100 0.371653563669878 3026 4246530
SGTC_2743 auranofin 4.32 µM -0.328864863697771 0.377973897975598 no 2101 0.371128916563703 3018 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold.
SGTC_2406 ethylparaben 405.7 µM -0.329782161514029 0.377672336657784 no 2102 0.370782283544261 2886 8434 A possible steroid mimic.
SGTC_2060 5238662 140 µM -0.331091506503916 0.377242019161305 no 2103 0.370287683504263 3075 790130
SGTC_1457 k015-0032 57.3 µM -0.332128130363057 0.376901439779604 no 2104 0.369896254829891 2964 4302660
SGTC_1295 1013-0063 9.78 µM -0.332752023433544 0.376696507893599 no 2105 0.36966073803135 3108 6826038
SGTC_666 0272-0154 136 µM -0.333518024248894 0.376444944999077 no 2106 0.369371643073746 3034 6870312
SGTC_3324 9138759 60.749 µM -0.334164027452439 0.376232831387664 no 2107 0.369127893588298 3131 45595710
SGTC_403 arphamenine a 50 µM -0.335257491843164 0.375873880170309 no 2108 0.368715428300543 2995 5487158 An arginine aminopeptidase inhibitor.
SGTC_1034 k072-0165 12.7 µM -0.335679095813018 0.375735509031501 no 2109 0.368556435585237 3154 5835461
SGTC_929 2805-0021 398 µM -0.336541400886248 0.37545254882414 no 2110 0.368231318457285 3075 3098024
SGTC_2620 irigenin 100 µM -0.338216283675561 0.374903137683408 no 2111 0.367600102792376 3182 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro.
SGTC_2027 5150920 200 µM -0.339842898669068 0.374369802690084 no 2112 0.366987420032878 3055 786715
SGTC_2608 thymoquinone 42.66 µM -0.340440444528113 0.374173939480196 no 2113 0.366762432653797 3079 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC).
SGTC_440 fluspirilene 35.1 µM -0.340875337388692 0.374031410983976 no 2114 0.366598715991669 3224 3396 An atypical antipsychotic.
SGTC_1347 1493-0251 600 nM -0.34186220143413 0.373708047525994 no 2115 0.366227298257506 3145 3986378
SGTC_1460 k062-0059 9.15 µM -0.342930350470188 0.373358149770333 no 2116 0.36582542917242 2904 1373085
SGTC_592 k241-0073 46.5 µM -0.342958723481011 0.373348856934341 no 2117 0.365814756416068 3145 4230158
SGTC_83 0170-0301 39.027 µM -0.344487737339983 0.372848177597313 no 2118 0.365239758267279 2982 3089716
SGTC_3237 9133362 49.47 µM -0.344821105368206 0.372739043900585 no 2119 0.36511443266145 3107 43845137
SGTC_1180 1193-0155 285 µM -0.345090945550507 0.372650714604867 no 2120 0.365013000115999 3148 2921347
SGTC_3173 9105693 49.47 µM -0.345554777893479 0.372498899702402 no 2121 0.364838668264281 3176 17096658
SGTC_1446 4239-0190 62 µM -0.345734181115719 0.372440185342333 no 2122 0.364771246874513 3026 1340085
SGTC_1001 4048-4355 44.4 µM -0.346462041590094 0.372202004539652 no 2123 0.364497753097138 3002 21824233
SGTC_2323 6148992 148.28 µM -0.34746383212258 0.371874264423825 no 2124 0.364121442822874 3030 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42
SGTC_1280 0880-0253 10.1 µM -0.347816277000883 0.371758982614436 no 2125 0.363989082371282 3021 6836607
SGTC_3129 9127257 49.47 µM -0.348019063257597 0.371692658114819 no 2126 0.363912933472777 3021 837894
SGTC_888 0916-0002 6.97 µM -0.349087502446963 0.371343270866042 no 2127 0.363511809358831 3184 2802138 YIL048W NEO1
SGTC_2604 4'-hydroxychalcone 11.32 µM -0.350926747619399 0.370742072960367 no 2128 0.362821652168729 3156 5282362
SGTC_1481 3346-2004 36 µM -0.351108138676932 0.370682798352965 no 2129 0.362753611194738 3098 2770522
SGTC_1220 1838-0075 193 µM -0.351226639124223 0.37064407667096 no 2130 0.362709163240636 3046 5529645
SGTC_326 k292-0812 17.5 µM -0.352222217635507 0.370318809220761 no 2131 0.362335807990201 3106 3579357
SGTC_1728 st035614 33.7865 µM -0.353544427653855 0.369886970681482 no 2132 0.361840163976257 3093 15945546
SGTC_1201 1889-3372 45.9 µM -0.35368470760881 0.36984116435896 no 2133 0.361787592171803 3034 5392199
SGTC_1609 st001574 46.4 µM -0.354282633256067 0.369645941394199 no 2134 0.361563540737072 3018 3960012
SGTC_467 ro 31-8220 72.8 µM -0.354528333589251 0.369565729873102 no 2135 0.361471487002605 3056 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7
SGTC_3203 9113543 49.47 µM -0.355780402381989 0.369157066757804 no 2136 0.361002513347872 3178 17018012
SGTC_2218 6965428 192.983 µM -0.355803577769601 0.369149503928115 no 2137 0.360993834764291 3102 675684
SGTC_3334 9142812 21.919 µM -0.356043151958933 0.369071326595158 no 2138 0.360904124617637 3135 45283678
SGTC_3049 9092223 49.47 µM -0.356367725386938 0.368965421133013 no 2139 0.360782598147935 3122 8623917
SGTC_2187 6125751 200 µM -0.358330090887115 0.368325330633051 no 2140 0.360048150940053 3068 874498
SGTC_2272 7805186 180 µM -0.360420292047423 0.367643944061601 no 2141 0.359266427021076 3171 2956062 YPR165W RHO1
SGTC_3298 9116858 71.43 µM -0.360657959930674 0.367566492819403 no 2142 0.359177577738087 3181 2506942
SGTC_1992 st073643 23.3 µM -0.361187964613874 0.367393794223525 no 2143 0.358979469288289 3011 3161292
SGTC_3231 9132313 49.47 µM -0.362502614818202 0.366965539789739 no 2144 0.358488234939708 3096 4905967
SGTC_2036 5160441 105 µM -0.362670632394366 0.366910819069366 no 2145 0.358425470069214 3084 134534 YIL048W NEO1
SGTC_2095 5432005 200 µM -0.363578924009601 0.366615049415465 no 2146 0.358086233698255 3040 783734
SGTC_3207 9114163 49.47 µM -0.3640027739012 0.366477057023837 no 2147 0.357927969000629 3302 849233
SGTC_3299 9121982 43.1275 µM -0.364353147097248 0.366362999397806 no 2148 0.357797158785964 3072 17594604 YPL160W CDC60
SGTC_871 0574-0004 149 µM -0.364416288082409 0.366342446252612 no 2149 0.357773587166076 3030 9551173
SGTC_3175 9106517 49.47 µM -0.36472487994923 0.36624200142899 no 2150 0.357658392298787 3127 41468073
SGTC_1532 4',5'-dihydroxyflavone 78.7 µM -0.364763232547971 0.366229518525515 no 2151 0.357644076487043 3053 165521
SGTC_2301 7769476 200 µM -0.365752370393748 0.365907625467389 no 2152 0.357274931863286 3109 977820
SGTC_1373 2887-0003 58.5 µM -0.36601650193473 0.365821685648391 no 2153 0.357176380980204 3104 776948
SGTC_1434 4073-0095 163 µM -0.367761219639131 0.365254180520801 no 2154 0.356525643902251 3129 24133745
SGTC_1039 k821-0043 94 µM -0.368134301785334 0.365132866155159 no 2155 0.356386547489309 3183 15992768
SGTC_160 3453-0671 289.699 µM -0.368941120285107 0.364870560785086 no 2156 0.356085806270509 3046 5322268
SGTC_2678 equilin 100 µM -0.368994787365449 0.364853115281766 no 2157 0.356065805064428 3171 3247 Equilin is an estrone commonly used hormone replacement therapy
SGTC_2549 cedrol 20.94 µM -0.369366671917196 0.364732234836889 no 2158 0.355927218143378 3198 6708665 A sedative which affects the nervous system.
SGTC_2600 tangeritin 87.95 µM -0.369802150892389 0.364590700224788 no 2159 0.355764956249443 3019 68077 A bioactive flavone.
SGTC_1156 4092-0367 4.88 µM -0.370451595666422 0.364379659080459 no 2160 0.355523018053583 3085 1357585
SGTC_202 3594-0513 34.79 µM -0.370488615827391 0.364367630385233 no 2161 0.355509228655081 3066 708429
SGTC_1663 st014140 55.4 µM -0.371033720654978 0.36419052885523 no 2162 0.355306208013905 3102 4207120
SGTC_2584 androsterone 48.74 µM -0.372033727187798 0.363865707701927 no 2163 0.354933869066393 3175 2754130 A steroid.
SGTC_768 0384-0033 77.3 µM -0.372150811428387 0.363827682903762 no 2164 0.354890283379307 3068 3965305 YMR134W ERG29
SGTC_1705 st027868 56.3335 µM -0.374844473503287 0.362953248245883 no 2165 0.3538880683336 3122 292948
SGTC_1182 1222-0449 220 µM -0.375843666372691 0.362629064863042 no 2166 0.353516561347863 3131 658318
SGTC_1590 st077108 57.8 µM -0.378902906040451 0.36163712212722 no 2167 0.352379983063055 3173 5489485
SGTC_3153 9100258 49.47 µM -0.379408263312966 0.361473351867973 no 2168 0.352192357624294 3063 25236848
SGTC_2636 apigenin dimethyl ether 100 µM -0.380642686217154 0.36107342132212 no 2169 0.351734201234835 3216 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_1700 st030840 7.9285 µM -0.381291388501502 0.360863314418826 no 2170 0.351493521441504 3172 5499307
SGTC_791 1348-1292 225 µM -0.382215290915215 0.360564145977544 no 2171 0.351150840407867 3115 5437054
SGTC_230 MPP+ 141.667 µM -0.382557361551965 0.36045340186736 no 2172 0.351023995002129 3120 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death.
SGTC_566 0958-0068 16.5 µM -0.383502979131968 0.360147322582695 no 2173 0.35067343088607 3238 6815365
SGTC_1760 st045453 10.4495 µM -0.384337735356541 0.359877201585747 no 2174 0.350364071470761 3204 3323419 YIL048W NEO1
SGTC_2531 methyl deoxycholate 70.07 µM -0.385236039115004 0.359586595233625 no 2175 0.350031272293738 3044 16667744 Haematoxylin.
SGTC_618 k072-0232 33.2 µM -0.386922600444263 0.359041202491672 no 2176 0.349406754536172 3150 5872756 YGL099W LSG1
SGTC_1694 st024011 44.9 µM -0.387018706000679 0.359010132940137 no 2177 0.349371179809647 3186 2787533
SGTC_1139 k015-0024 46.9 µM -0.387236007439698 0.358939885932115 no 2178 0.349290747723382 3206 2766652
SGTC_1291 0993-0025 5.79 µM -0.389089355353997 0.358340948446041 no 2179 0.348605023748624 3199 4353356
SGTC_2129 girgensonine 121.053 µM -0.389461126526707 0.358220846854097 no 2180 0.348467530832981 3133 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_485 niflumic acid 177 µM -0.392450857717193 0.357255517717634 no 2181 0.347362557349414 3197 4488 A COX2 inhibitor.
SGTC_2462 5162487 171.77 µM -0.392936650338082 0.357098750281513 no 2182 0.347183135614958 3192 2259986
SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM -0.393066724823537 0.357056778760469 no 2183 0.347135099959635 3064 442882
SGTC_2125 5246583 200 µM -0.393169913834593 0.357023483685848 no 2184 0.347096994680775 3268 835267
SGTC_511 blebbistatin 171 µM -0.39326449293064 0.35699296765182 no 2185 0.347062070199182 3250 3476986 A myosin inhibitor.
SGTC_1866 st057638 64 µM -0.39431888783779 0.356652828142158 no 2186 0.346672810077431 3110 688802
SGTC_92 0063-0024 660.874 µM -0.39464650427261 0.356547164848588 no 2187 0.346551894005765 3141 3594437
SGTC_1734 st037168 69.4 µM -0.396109084774927 0.35607558579892 no 2188 0.346012278309126 3171 708907
SGTC_1281 0884-0031 11.8 µM -0.396146088230338 0.356063657646066 no 2189 0.345998630019221 3117 1548255
SGTC_2807 7945238 51.95 µM -0.3961942467608 0.356048133838914 no 2190 0.345980867610532 3171 17148797
SGTC_956 1185-0240 191 µM -0.396497455503717 0.355950400581558 no 2191 0.345869042298962 3101 1416193
SGTC_1339 1486-1321 22.7 µM -0.39661648096654 0.355912037697478 no 2192 0.345825148625584 3120 3469382
SGTC_2257 7960413 200 µM -0.397749942386001 0.355546786921943 no 2193 0.34540725972772 3078 2974689 YIL048W NEO1
SGTC_2290 7904846 200 µM -0.398575410236029 0.355280868561396 no 2194 0.345103041590404 3164 2962154
SGTC_1398 3558-0053 112 µM -0.399294608545005 0.355049241570976 no 2195 0.344838069630233 3033 4532369
SGTC_1547 harmine 94.2 µM -0.399810369218404 0.354883167235554 no 2196 0.344648096392455 3139 5280953 A monoamine oxidase inhibitor YHR072W ERG7
SGTC_2236 dapsone 200 µM -0.400695393229918 0.354598254796968 no 2197 0.344322201461668 3172 2955 A bacterial DFR inhibitor. An anti-cancer agent.
SGTC_474 dl-dihydrosphingosine 5 µM -0.40222307149687 0.354106646527923 no 2198 0.343759932105294 3254 3058739 A sphingolipid protein kinase C inhibitor.
SGTC_1989 st071868 50.2 µM -0.403738473902463 0.353619228770315 no 2199 0.34320252217404 3223 16414057
SGTC_1104 tacrolimus 29.8 µM -0.403780759388424 0.35360563139943 no 2200 0.343186973203109 3178 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41
SGTC_1284 0929-0043 16 µM -0.405020406064994 0.353207092219203 no 2201 0.342731255667864 3165 1239883
SGTC_1401 3807-4679 7.6 µM -0.405698099625406 0.352989285701348 no 2202 0.342482219385329 3169 3291456
SGTC_565 1418-0001 44.5 µM -0.405971212905129 0.352901522394399 no 2203 0.342381876092699 3268 2862145
SGTC_2241 6772625 37.8075 µM -0.407328369334907 0.35246552450243 no 2204 0.341883414617083 3193 2285411
SGTC_2684 capsaicin 100 µM -0.409218810506628 0.351858527449775 no 2205 0.341189545614503 3235 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_743 1275-0778 158 µM -0.409500386138717 0.351768149284598 no 2206 0.341086241737135 3201 2849257 YMR203W TOM40
SGTC_3281 9140613 49.47 µM -0.411323113668682 0.351183305832687 no 2207 0.340417811689343 3154 16013766
SGTC_918 glabranin 770.725 nM -0.413940815236276 0.350344002139382 no 2208 0.339458725822947 3168 124049 Also referred to as licorice root.
SGTC_475 α-linolenic acid 10 µM -0.414307243702037 0.3502265737476 no 2209 0.339324554779926 3359 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_570 0987-0065 62.6 µM -0.416930572131075 0.349386301159325 no 2210 0.338364595492601 3120 3104428
SGTC_925 2064-1272 59.6 µM -0.41748424065282 0.349209050933956 no 2211 0.338162124502456 3142 6815817
SGTC_2630 antimycin a 100 µM -0.418072853691341 0.349020649712845 no 2212 0.337946925975137 3092 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain.
SGTC_3002 9075603 71.4286 µM -0.418099751172977 0.349012041348851 no 2213 0.33793709344735 3193 20105405
SGTC_816 0325-0417 81.3 µM -0.419698887231275 0.348500388032212 no 2214 0.337352719056318 3210 68101
SGTC_536 3852-0578 10.6 µM -0.420085190076173 0.348376829366073 no 2215 0.337211610650053 3276 2869208
SGTC_3208 9114115 49.47 µM -0.422097173257514 0.347733558463879 no 2216 0.336477045561074 3202 650895
SGTC_1648 st011736 69.8 µM -0.422382017760463 0.347642523390884 no 2217 0.336373100577643 3289 2855514
SGTC_1894 3',6'-dihydroxyflavone 78.7 µM -0.427571659103339 0.345985479143246 no 2218 0.334481501621301 3263 688662
SGTC_462 ag-879 158 µM -0.429525397570442 0.345362414870445 no 2219 0.333770457562572 3236 6809654 Ag-879 is a 5-Lipoxygenase inhibitor.
SGTC_3034 9090421 49.47 µM -0.430825076519199 0.344948167752089 no 2220 0.333297782305496 3222 17173761
SGTC_2071 5230951 39.92 µM -0.431477785725065 0.344740199565416 no 2221 0.333060500761866 3273 1799272
SGTC_3331 9141060 1.957 µM -0.431749519612846 0.344653632715769 no 2222 0.332961736133777 3135 4906567 YPR165W RHO1
SGTC_175 3793-3120 23.7 µM -0.432179506432565 0.344516667509293 no 2223 0.332805476436904 3161 5322297
SGTC_2474 5321570 43.32 µM -0.432870897514657 0.344296479031224 no 2224 0.332554281807526 3233 2841384
SGTC_2936 9038235 15.59 µM -0.433847833135964 0.343985442672199 no 2225 0.332199471954623 3157 4749415
SGTC_1490 4089-0339 670 nM -0.434036491831166 0.34392538974691 no 2226 0.332130970971148 3270 742542
SGTC_1983 st071813 46.9 µM -0.434760655956315 0.343694913889321 no 2227 0.331868082876116 3225 11838595
SGTC_493 zm226600 134 µM -0.435494602384177 0.34346138393617 no 2228 0.3316017280211 3323 5240098 A potassium channel opener. YCR052W RSC6
SGTC_1586 deoxycorticosterone acetate 53.7 µM -0.435754576135913 0.343378678792609 no 2229 0.331507401938399 3283 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE.
SGTC_1338 1486-1223 76 µM -0.435829412156673 0.343354872687334 no 2230 0.331480251221109 3201 3444526
SGTC_2273 7815444 169.05 µM -0.435837824143852 0.343352196786843 no 2231 0.331477199384033 3298 2824616
SGTC_1315 1237-0019 3.69 µM -0.436377294009081 0.343180604790039 no 2232 0.331281505136097 3288 825140
SGTC_1937 st074714 47.2 µM -0.436884015124666 0.343019458801887 no 2233 0.331097732544454 3146 17250970
SGTC_2839 9003951 25.97 µM -0.438416442634725 0.342532294442551 no 2234 0.330542214611443 3280 2990634
SGTC_1161 k007-0610 110 µM -0.438433296018434 0.342526938143867 no 2235 0.330536107189559 3307 5843850
SGTC_1689 st020265 53.493 µM -0.439654717440502 0.342138833528312 no 2236 0.330093602015895 3305 5758320 YPR016C TIF6
SGTC_706 4262-0057 46.9 µM -0.440036633451091 0.342017514546248 no 2237 0.32995528751701 3172 883298
SGTC_2149 5554786 194.827 µM -0.440349861398328 0.341918027103982 no 2238 0.32984186639814 3190 745063 YPR165W RHO1
SGTC_1736 st036774 51 µM -0.442081881483906 0.341368101296314 no 2239 0.329214977499779 3388 1272247
SGTC_2431 5490079 200 µM -0.443164792398433 0.34102444214973 no 2240 0.328823271442799 3230 5722345
SGTC_697 0508-1955 564 µM -0.443488960864184 0.340921593704337 no 2241 0.328706051099444 3329 6243113
SGTC_3003 9075612 71.4286 µM -0.443850924494666 0.340806768012571 no 2242 0.328575183817871 3238 6501993
SGTC_2827 7993847 71.43 µM -0.445171765110693 0.340387883023274 no 2243 0.328097814766736 3254 2985692
SGTC_274 sirtinol 40.1 µM -0.447184083087578 0.339750084780861 no 2244 0.327371076408322 3217 6836442 NAD-dependent acetyltransferase inhibitor.
SGTC_192 3455-0609 60.9 µM -0.447634216268174 0.339607479088966 no 2245 0.327208602490644 3315 3769639
SGTC_2894 9048625 32.47 µM -0.448827397650971 0.339229581081248 no 2246 0.326778086511419 3351 4092861
SGTC_1071 trifluoperazine 6.31 µM -0.45062758964787 0.338659739952255 no 2247 0.326128989260413 3315 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels.
SGTC_56 0957-0365 83.25 µM -0.450809120697312 0.338602297738834 no 2248 0.326063563592432 3292 6752360
SGTC_424 splitomicin 100 mM -0.450989946983076 0.338545082267672 no 2249 0.325998397251377 3244 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_2088 5278280 127.392 µM -0.451031898540341 0.338531808855498 no 2250 0.325983279470468 3294 791502
SGTC_369 0957-0393 4.5 µM -0.45109788400001 0.338510931557168 no 2251 0.325959501343853 3240 6997992
SGTC_491 tetrandrine 80.3 µM -0.452889181398162 0.337944368464294 no 2252 0.325314270775432 3258 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_817 1391-0715 46 µM -0.453189484619984 0.337849422502389 no 2253 0.325206151842854 3227 1353946
SGTC_2834 9001755 58.44 µM -0.453242771969616 0.337832575879689 no 2254 0.325186968199688 3177 2989575
SGTC_2199 6590217 200 µM -0.453577390741954 0.337726794666592 no 2255 0.32506651479405 3218 703109
SGTC_761 k216-0224 480 µM -0.453765891351983 0.337667210637081 no 2256 0.324998667891773 3359 1340404
SGTC_567 1080-0542 68.4 µM -0.455182943711393 0.337219418355691 no 2257 0.32448881507362 3291 5950415
SGTC_14 0354-0009 295 µM -0.456949278030392 0.336661574827457 no 2258 0.323853751641537 3214 1713507
SGTC_900 1112-0045 141 µM -0.457431260487457 0.33650941750955 no 2259 0.323680549786708 3244 56211 YIL048W NEO1
SGTC_1309 pyrazolanthrone 13.4 µM -0.458399628260907 0.336203793866685 no 2260 0.323332679348939 3301 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14
SGTC_1837 st055472 66.5 µM -0.459241474188683 0.335938189333711 no 2261 0.323030385272013 3379 676091
SGTC_1500 4488-1866 171 µM -0.460121132836421 0.33566074230025 no 2262 0.322714638062707 3358 2900003
SGTC_3316 9136639 10.545 µM -0.460775933941066 0.335454274164422 no 2263 0.322479684812455 3302 4903665
SGTC_673 1082-0474 110 µM -0.461131520094621 0.335342173585194 no 2264 0.322352124427746 3228 3098046
SGTC_1991 st073000 8.92 µM -0.461268586482572 0.335298966532292 no 2265 0.322302959814899 3390 4301969 YIL048W NEO1
SGTC_2013 4024628 200 µM -0.464587082299895 0.334253552472558 no 2266 0.321113592343056 3341 5230760
SGTC_3318 9139014 38.6185 µM -0.465052096615348 0.334107163063064 no 2267 0.320947074740416 3224 16643984
SGTC_2753 fluvastatin 17.09 µM -0.465881269260634 0.33384619696218 no 2268 0.320650244552144 3273 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5
SGTC_321 4534-3890 65.3 µM -0.466640600378565 0.33360728260598 no 2269 0.320378517043935 3294 699746
SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM -0.467536698032161 0.33332542309797 no 2270 0.320057971319236 3384 5393153
SGTC_2585 alliin 100 µM -0.469544375614826 0.332694267804852 no 2271 0.319340286774398 3405 87310 A garlic compound which reacts with lipids.
SGTC_1370 2001-0092 44.6 µM -0.4720383315894 0.331910900817781 no 2272 0.318449714296697 3420 790957
SGTC_2211 7117706 200 µM -0.472458925143237 0.331778862044761 no 2273 0.31829962671306 3297 822771
SGTC_2050 5263056 171 µM -0.473682008200681 0.331395013005992 no 2274 0.31786334261533 3354 763468 YGL055W OLE1
SGTC_3114 9122766 49.47 µM -0.474093877071528 0.331265793034717 no 2275 0.317716482344777 3276 17176985
SGTC_110 0850-0284 111.64 µM -0.474595279015699 0.331108510021285 no 2276 0.317537735928509 3138 3906265
SGTC_2582 agaric acid 100 µM -0.475694792795703 0.330763711749307 no 2277 0.317145915608215 3330 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase.
SGTC_2786 7743617 45.45 µM -0.477088542656863 0.330326849832749 no 2278 0.316649536468517 3228 583674
SGTC_3144 9087057 49.47 µM -0.477150957033448 0.330307291851785 no 2279 0.316627315519759 3336 17249618
SGTC_716 1683-5115 658 µM -0.477214025946446 0.330287529238153 no 2280 0.316604862213235 3352 723597
SGTC_1225 1216-0074 20.6 µM -0.477698514992871 0.330135730617539 no 2281 0.31643240071081 3244 4241466
SGTC_914 3820-6779 408 µM -0.480971564175849 0.329110962381843 no 2282 0.315268354434052 3212 2893481
SGTC_2263 7948595 193.29 µM -0.483117789534737 0.328439690434813 no 2283 0.314506051738274 3292 2971371
SGTC_1475 4092-1048 11.7 µM -0.483311447248024 0.328379147567579 no 2284 0.314437306634367 3354 2881759
SGTC_145 3737-0113 38.366 µM -0.485567746665108 0.327674097157503 no 2285 0.31363683446357 3365 6849351
SGTC_3195 9113082 49.47 µM -0.486796602287338 0.327290361359432 no 2286 0.313201239211081 3342 17018038
SGTC_2646 retinol 96.75 µM -0.487178148488507 0.327171252700681 no 2287 0.313066044633298 3362 445354 A vitamin A analog and teratogen.
SGTC_2111 5486399 200 µM -0.488345976233413 0.326806797095426 no 2288 0.312652400433892 3297 689674
SGTC_2014 4013930 200 µM -0.488556136226988 0.326741227905534 no 2289 0.312577986860518 3376 64556
SGTC_1014 4130-3005 69.3 µM -0.488688466405008 0.326699944093534 no 2290 0.312531135233439 3224 743608
SGTC_529 4076-0302 30.3 µM -0.492863542929515 0.325398513063517 no 2291 0.3110545043548 3262 5816522
SGTC_1804 st050076 49.1 µM -0.494975320702924 0.324741050380675 no 2292 0.310308770672587 3354 3895976
SGTC_1035 k081-0041 55.2 µM -0.495464967750289 0.324588685740197 no 2293 0.310135972413138 3397 731709
SGTC_586 0957-0265 8.15 µM -0.49628863980358 0.324332447968022 no 2294 0.309845390066787 3307 6752309 YPR165W | YPR107C RHO1 | YTH1
SGTC_1076 itraconazole 331 nM -0.497645855577674 0.323910410478417 no 2295 0.309366838562659 3345 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1
SGTC_297 0986-0032 24 µM -0.498648802123657 0.323598681286074 no 2296 0.309013409233772 3283 2847425
SGTC_2456 5770359 74.46 µM -0.498988898585475 0.323493002843895 no 2297 0.308893602411763 3395 3118787
SGTC_819 1013-0258 27.7 µM -0.499046935551583 0.323474970393266 no 2298 0.308873159582368 3295 5753198
SGTC_794 k038-0031 316 µM -0.499174106467768 0.323435459038796 no 2299 0.308828367213435 3407 6624242
SGTC_1320 1313-0481 95.3 µM -0.499860836631282 0.32322212989625 no 2300 0.308586535027313 3431 6813365 YLR208W SEC13
SGTC_3260 9137109 49.47 µM -0.503300549817492 0.322154476702951 no 2301 0.307376489973178 3297 17478346
SGTC_1675 st018485 24.5 µM -0.504209466420418 0.321872602396085 no 2302 0.307057094446268 3289 3323024
SGTC_2544 sphondin 68.51 µM -0.507219937481387 0.320939723969962 no 2303 0.306000253656367 3428 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31
SGTC_788 1182-0090 188 µM -0.508032178394377 0.320688221663172 no 2304 0.305715388387956 3445 5715185
SGTC_674 0498-0004 451 µM -0.509505386220451 0.320232267571892 no 2305 0.305199011934883 3333 4231473
SGTC_2110 5483698 200 µM -0.509842939416967 0.320127833890255 no 2306 0.305080750147492 3313 2848765 YHR062C RPP1
SGTC_2114 5491910 81.25 µM -0.51024274936239 0.320004157377278 no 2307 0.304940703031602 3400 2849228
SGTC_1687 st020778 55.3625 µM -0.511232599371456 0.319698044979152 no 2308 0.304594097139704 3348 4259299
SGTC_858 0438-0351 2.77 µM -0.512160990512628 0.319411050386462 no 2309 0.304269171041079 3335 2799119
SGTC_2327 6189656 200 µM -0.512174611550845 0.319406840504282 no 2310 0.304264404985388 3371 5349088
SGTC_3087 9117406 49.47 µM -0.512800533649904 0.319213410600059 no 2311 0.304045428222274 3382 42546093
SGTC_2148 5546263 113.568 µM -0.513428165112832 0.319019501851196 no 2312 0.303825924006483 3272 792097
SGTC_95 0471-0001 561.058 µM -0.513792154580291 0.318907068822346 no 2313 0.303698656821379 3319 4015405
SGTC_1028 k015-0029 4.8 µM -0.513809680333235 0.318901655697383 no 2314 0.303692529625693 3354 4588309
SGTC_517 1365-0151 113 µM -0.514793017320469 0.318597997368983 no 2315 0.303348832653301 3433 768657
SGTC_378 3970-0959 8.33 µM -0.517800019549949 0.317670179577944 no 2316 0.302298902345511 3394 6615653
SGTC_1988 st071872 53.4 µM -0.517935593132828 0.317628374929372 no 2317 0.302251603661459 3420 16414116
SGTC_343 4130-2827 29.8 µM -0.518251303384972 0.317531033441698 no 2318 0.302141472071569 3333 1118244
SGTC_1399 3562-5772 25 µM -0.518997780598954 0.317300925747111 no 2319 0.301881144472383 3331 23847490
SGTC_2033 5192550 145 µM -0.519065821465871 0.317279955104148 no 2320 0.301857420809827 3310 182073
SGTC_1620 st003704 16.5 µM -0.521007814930852 0.316681667457152 no 2321 0.301180663662453 3417 2834414
SGTC_1570 verbenone 133 µM -0.52195624366366 0.316389650433644 no 2322 0.30085039834098 3444 29025 A natural terpanoid with antifungal properties.
SGTC_1869 3',7'-dimethoxyflavone 40.3 µM -0.522239073134986 0.31630259063194 no 2323 0.300751942057893 3333 688664
SGTC_926 2268-1401 59.4 µM -0.522778576509757 0.316136550400507 no 2324 0.300564174883358 3400 2931578
SGTC_1556 plumbagin 1.48 µM -0.52326323973089 0.315987419657191 no 2325 0.300395539264654 3373 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_20 0481-0013 4.944 µM -0.523437044581018 0.315933947243625 no 2326 0.300335075340087 3389 182045
SGTC_650 1328-0195 38 µM -0.526932382496883 0.314859398111717 no 2327 0.299120272656818 3397 2780821
SGTC_2887 9044784 58.44 µM -0.527054125682495 0.314821999553428 no 2328 0.299078001105612 3379 6465546
SGTC_3270 9137563 49.47 µM -0.533704551243868 0.312781934501368 no 2329 0.296772979919384 3379 17015724
SGTC_3009 9080819 71.4286 µM -0.533940979126246 0.312709513532738 no 2330 0.29669118449404 3383 17027216
SGTC_1861 st057647 17.4 µM -0.53593030820595 0.312100442438683 no 2331 0.296003358429605 3467 688668
SGTC_2573 2',4'-dihydroxychalcone 15.04 µM -0.536397025374901 0.311957622337673 no 2332 0.295842093399418 3333 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_2794 7785382 27.27 µM -0.536680209300602 0.311870979013625 no 2333 0.29574426438332 3447 2205081
SGTC_3048 9093155 49.47 µM -0.537715464688508 0.311554319542838 no 2334 0.295386750532888 3419 25236002
SGTC_194 1486-1323 56.904 µM -0.541957007465759 0.31025839144597 no 2335 0.293924061682339 3388 5178754
SGTC_2083 5306046 65.942 µM -0.54370462401154 0.309725121615357 no 2336 0.293322374972361 3391 539837
SGTC_610 4215-0184 155 µM -0.544577480378307 0.309458926955596 no 2337 0.293022073248306 3422 5605015
SGTC_2888 9058547 12.99 µM -0.545491467044599 0.309180295921307 no 2338 0.292707773816308 3358 16476514
SGTC_1020 4335-0961 93.3 µM -0.545541129408645 0.309165159371548 no 2339 0.292690700533471 3274 669075
SGTC_497 capsazepine 133 µM -0.548641038117683 0.308220982844008 no 2340 0.29162590848373 3363 2733484 A calcium channel blocker.
SGTC_2041 5107442 45.335 µM -0.548871259586036 0.308150912006785 no 2341 0.29154690147542 3491 793005
SGTC_589 1227-0070 34.1 µM -0.549915180330043 0.307833269185229 no 2342 0.291188775851417 3465 2841384
SGTC_1533 dihydroergotamine mesylate 29.4 µM -0.551270255220199 0.307421163517883 no 2343 0.290724212820963 3483 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release.
SGTC_1392 3455-1037 33.9 µM -0.551527940284618 0.307342823762418 no 2344 0.290635909374238 3494 981132
SGTC_942 3253-1115 227 µM -0.552400016816166 0.307077765887112 no 2345 0.29033715955041 3499 46497897
SGTC_3117 9124945 49.47 µM -0.552508316124044 0.307044856560096 no 2346 0.290300069178205 3294 17592065
SGTC_2001 4023502 57.655 µM -0.552704258279964 0.306985318814332 no 2347 0.290232968503163 3411 108941 YCR052W RSC6
SGTC_3025 9087895 49.47 µM -0.553147425183566 0.306850679693256 no 2348 0.290081232160867 3466 17173641
SGTC_328 k915-0120 63.5 µM -0.553648450151487 0.306698494011009 no 2349 0.289909730533284 3446 6624543
SGTC_1945 st075991 56.6 µM -0.553821112888099 0.306646055647436 no 2350 0.289850638828581 3369 1084980
SGTC_496 calpeptin 138 µM -0.553862653777246 0.306633440103873 no 2351 0.289836422811766 3411 73364 A calpain inhibitor.
SGTC_1729 st035615 45.989 µM -0.556076008600289 0.305961598455457 no 2352 0.289079447598731 3393 17385451
SGTC_990 3985-0011 41.3 µM -0.556393065949997 0.305865412240236 no 2353 0.288971089041223 3373 5399565 YGL099W LSG1
SGTC_1378 2093-0007 380 nM -0.557091480642151 0.305653580250498 no 2354 0.28873246398575 3427 3618014
SGTC_2820 7989630 71.43 µM -0.559783915280906 0.304837562990498 no 2355 0.287813418090877 3386 2984098
SGTC_121 0557-0495 61.343 µM -0.560624285847908 0.304583063695004 no 2356 0.287526846015872 3442 3104427
SGTC_2324 6149169 200 µM -0.560971931535897 0.304477809709821 no 2357 0.287408335935055 3355 2888231
SGTC_126 0417-1624 672.48 µM -0.562157072517703 0.304119115488695 no 2358 0.287004503066674 3547 41912 YDL195W SEC31
SGTC_154 3389-1638 511.116 µM -0.562668145530622 0.303964492498111 no 2359 0.286830439605802 3385 5238686
SGTC_1033 k072-0102 21.3 µM -0.564479616438766 0.303416722127428 no 2360 0.286213884277441 3479 5965931
SGTC_1788 fluconazole 20 µM -0.564492906462879 0.303412704989509 no 2361 0.286209363188938 3448 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11
SGTC_167 3672-0051 66.205 µM -0.564742298801953 0.303337326281418 no 2362 0.286124529540494 3427 3237971
SGTC_2960 9079389 5.97 µM -0.568223888322877 0.302285892868027 no 2363 0.284941476375803 3477 16457355
SGTC_2249 haloperidol 116.36 µM -0.569001888590092 0.302051161975833 no 2364 0.284677429140456 3462 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_1815 st051655 58.2 µM -0.571429907090133 0.30131913007727 no 2365 0.283854130512686 3454 5984156
SGTC_2107 5363541 170.161 µM -0.571572876046268 0.30127605077458 no 2366 0.283805687792995 3461 244052
SGTC_1424 4048-1941 275 µM -0.571776967297153 0.301214558952593 no 2367 0.283736541630605 3516 X1424
SGTC_3108 9121785 49.47 µM -0.571979299533614 0.301153602695432 no 2368 0.283667999387204 3454 17140271
SGTC_1880 MG-132 525 µM -0.573857879239236 0.300587912042965 no 2369 0.283031989055797 3475 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1
SGTC_3149 9097855 49.47 µM -0.57395067621701 0.30055998082678 no 2370 0.283000589539799 3475 25236625 YMR079W SEC14
SGTC_663 1486-0733 13.9 µM -0.574829944222101 0.300295385726001 no 2371 0.282703156512922 3421 722445 YPR165W RHO1
SGTC_3354 9151612 71.43 µM -0.574982757702213 0.30024941083113 no 2372 0.282651479094586 3479 27261949
SGTC_2467 5474540 200 µM -0.575971439468423 0.299952036635504 no 2373 0.282317243204778 3439 5413519
SGTC_137 0438-0332 85.389 µM -0.577487653839618 0.299496251120028 no 2374 0.281805038233281 3508 2063393 YER012W | YPR107C PRE1 | YTH1
SGTC_2469 5655019 90.81 µM -0.577613805381651 0.299458343162814 no 2375 0.281762442122941 3525 2788239
SGTC_47 0149-0135 24.25 µM -0.578557650321087 0.29917479115554 no 2376 0.281443843593654 3395 5239155
SGTC_389 tpck 16.7 µM -0.578836591072507 0.299091014484089 no 2377 0.281349719346789 3455 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.
SGTC_2092 5303694 80.6725 µM -0.580370200067305 0.298630602887023 no 2378 0.280832498263421 3447 1963699
SGTC_2950 9072895 21.46 µM -0.585480912745294 0.297098624842377 no 2379 0.279112198583864 3484 17332245
SGTC_2829 7992743 58.44 µM -0.588333717602556 0.296245039022813 no 2380 0.278154159000437 3462 16462845
SGTC_74 000s-0487 160.283 µM -0.588385142922131 0.296229662413416 no 2381 0.278136903883957 3497 677548
SGTC_2213 7173844 200 µM -0.591058754910359 0.295430734412884 no 2382 0.277240527025256 3463 892728
SGTC_394 menadione 8.33 µM -0.591212184926253 0.295384916583973 no 2383 0.2771891297359 3491 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_693 4161-2696 114 µM -0.593056290386114 0.294834479075112 no 2384 0.276571740615438 3487 805759
SGTC_616 4092-0450 108 µM -0.596344679193331 0.293854120015471 no 2385 0.275472494535607 3514 787165
SGTC_2693 st077581 40.7 µM -0.597215590724082 0.29359473014199 no 2386 0.275181725697316 3516 25238761
SGTC_2758 dehydroepiandrosterone 69.35 µM -0.597622989673483 0.293473427974114 no 2387 0.275045760427626 3490 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem]
SGTC_671 0560-0003 407 µM -0.59801713654431 0.293356093682665 no 2388 0.274914249406738 3434 3238678
SGTC_3326 9140064 16.379 µM -0.603289500850895 0.291788648545137 no 2389 0.273158058126555 3489 1868434
SGTC_983 1491-0821 12.2 µM -0.604985666724578 0.291285218588737 no 2390 0.272594260203382 3518 46495113
SGTC_3093 9117344 49.47 µM -0.606350859799988 0.290880317605369 no 2391 0.272140896110427 3532 24824913
SGTC_866 0495-0101 262 µM -0.611017091841519 0.289498355551061 no 2392 0.270594132573678 3440 635694
SGTC_1480 1070-0044 41.2 µM -0.611098582610649 0.289474248475744 no 2393 0.270567159060853 3511 3124987
SGTC_80 0159-0065 512.242 µM -0.612316886125119 0.289113955280057 no 2394 0.270164059790498 3514 1548079
SGTC_153 4077-0274 519.67 µM -0.61316839501038 0.288862260823874 no 2395 0.269882500060152 3640 3121976
SGTC_815 1582-0027 36.9 µM -0.614129310062412 0.288578351311794 no 2396 0.269564940625879 3548 3128206
SGTC_2906 7926292 26.41 µM -0.614389239272776 0.288501575885972 no 2397 0.269479072425848 3540 2966319
SGTC_518 1021-0119 62.6 µM -0.615069425151845 0.288300714593739 no 2398 0.269254436386124 3454 1097762
SGTC_3225 9130819 49.47 µM -0.615531767774839 0.288164220842692 no 2399 0.26910179820772 3546 4547121
SGTC_3253 9135987 49.47 µM -0.619066258102489 0.287121770026543 no 2400 0.267936355269774 3545 4182430
SGTC_2797 7859098 81.82 µM -0.619066762584155 0.287121621363925 no 2401 0.267936189106432 3526 972681
SGTC_349 k015-0014 24 µM -0.619409329462825 0.287020680840144 no 2402 0.267823368332317 3501 2196908
SGTC_318 1488-0629 67.2 µM -0.620055422059155 0.286830349390571 no 2403 0.26761064972949 3550 3662576
SGTC_1448 4255-0083 152 µM -0.621033903570134 0.28654221393456 no 2404 0.267288658117856 3595 5399660
SGTC_1294 1000-1494 117 µM -0.621196175581451 0.286494442640191 no 2405 0.267235277723627 3516 712797 YDL207W GLE1
SGTC_43 0570-0105 72.5 µM -0.62188335036789 0.286292186992896 no 2406 0.267009286922389 3580 1114046 YDL195W SEC31
SGTC_594 1487-1584 10.8 µM -0.623932969937764 0.285689326981982 no 2407 0.266335803385848 3502 5013332
SGTC_27 0485-0001 32.618 µM -0.624301124756204 0.285581104652855 no 2408 0.266214922702515 3512 2054479
SGTC_2700 st077718 96.8 µM -0.628113755083397 0.284461497510376 no 2409 0.26496471144224 3523 904970
SGTC_2312 7706453 155.7 µM -0.628182405914049 0.284441356918555 no 2410 0.264942227313002 3548 976098
SGTC_98 0074-0023 107.663 µM -0.631122524288851 0.283579433105496 no 2411 0.263980207295109 3538 3563821
SGTC_96 0929-0093 37.281 µM -0.633764116571908 0.282806093907016 no 2412 0.263117387232278 3539 6991579
SGTC_1350 1495-0454 146 µM -0.633908330621914 0.282763903710492 no 2413 0.263070324288203 3593 1069057
SGTC_3183 9108214 49.47 µM -0.636035332825492 0.282141995116788 no 2414 0.262376696428168 3502 4974831
SGTC_75 0159-0059 199.013 µM -0.640093298741705 0.280957326896737 no 2415 0.26105597269813 3683 5377270
SGTC_1951 sophoraflavanone G 9.2 µM -0.640561141102669 0.280820901359396 no 2416 0.260903926654932 3570 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity.
SGTC_2488 5268135 45.7 µM -0.642757950355992 0.280180727738205 no 2417 0.260190585981338 3574 1270356 YLR208W SEC13
SGTC_1252 0493-0875 34.8 µM -0.643997980384938 0.279819682259394 no 2418 0.259788371814019 3580 3960963
SGTC_676 falcarinol 140 µM -0.645686482215105 0.279328423505926 no 2419 0.259241208364017 3641 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer.
SGTC_2928 9011484 9.79 µM -0.647780734886446 0.278719696938359 no 2420 0.258563388728076 3579 2994751
SGTC_996 3970-0799 1.8 µM -0.649228344926675 0.278299304764502 no 2421 0.258095396553632 3657 6615648 YGL040C HEM2
SGTC_1971 st069429 63.5 µM -0.650674440367131 0.277879661291422 no 2422 0.257628332964441 3586 1246522 YGL099W LSG1
SGTC_3001 9076041 71.4286 µM -0.651191278452976 0.277729754637926 no 2423 0.257461509807324 3605 16004211
SGTC_976 1348-1067 47.6 µM -0.651580571195637 0.277616868043884 no 2424 0.257335892346453 3636 5310671 YGL099W LSG1
SGTC_2504 purpurogallin 52.29 µM -0.651941021748149 0.277512365061077 no 2425 0.257219610125045 3559 5281571 An antioxidant.
SGTC_2825 7998094 58.44 µM -0.652081101564179 0.277471757858642 no 2426 0.257174427408846 3562 2987815
SGTC_1893 st059353 36.1 µM -0.652647651447371 0.277307552511825 no 2427 0.256991728964071 3566 3112488
SGTC_2675 theaflavin digallate 100 µM -0.654272123424251 0.27683698915873 no 2428 0.256468251177854 3595 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative.
SGTC_2226 7298446 200 µM -0.657484806229874 0.275907519387169 no 2429 0.255434618680486 3606 3283010
SGTC_839 0122-0028 230 µM -0.658846581411876 0.275514003734823 no 2430 0.254997145767278 3613 759448
SGTC_2995 9067767 71.4286 µM -0.659100716848272 0.275440596145983 no 2431 0.254915547692425 3584 11673567
SGTC_559 1550-0661 158 µM -0.661317505835687 0.274800680028745 no 2432 0.254204358603934 3622 5830875
SGTC_2055 5235184 200 µM -0.661930457850855 0.27462386980256 no 2433 0.254007895437511 3624 2836034
SGTC_136 0097-0015 404.482 µM -0.662460555372935 0.274471004785811 no 2434 0.253838053027145 3636 4861337
SGTC_1066 ketoconazole 628 nM -0.662671217164906 0.274410267590473 no 2435 0.253770573877584 3635 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W
SGTC_1929 genistein trimethyl ether 50.5 µM -0.662798475756478 0.274373580098594 no 2436 0.253729814990719 3637 136420
SGTC_2860 9025725 38.96 µM -0.663221449569795 0.274251658004441 no 2437 0.253594367962613 3566 40546248
SGTC_3236 9132701 49.47 µM -0.664309563188241 0.273938132524489 no 2438 0.253246100774836 3587 24282524
SGTC_2354 9060492 162 µM -0.664608308807941 0.273852083953523 no 2439 0.253150526750903 3620 6471895
SGTC_2748 diazoxide 86.69 µM -0.666128666243975 0.273414378154489 no 2440 0.252664431525132 3557 3019 A potassium channel activatior.
SGTC_1769 st044406 64.4 µM -0.66663613497616 0.273268356754052 no 2441 0.252502290933821 3610 670903
SGTC_2423 st077119 87.2 µM -0.667089733011271 0.273137869061849 no 2442 0.252357408907989 3579 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae).
SGTC_1292 0kpi-0043 232 µM -0.667594271337433 0.272992763530217 no 2443 0.252196307731582 3609 3333905
SGTC_2286 7945697 125 µM -0.668911117323618 0.272614217960016 no 2444 0.251776089007621 3591 1245733
SGTC_253 dyclonine 31.25 µM -0.668964110045624 0.272598989925211 no 2445 0.251759186241493 3674 3180 An oral anasthetic.
SGTC_598 3937-0236 20.2 µM -0.669992701261041 0.27230349672142 no 2446 0.251431221480169 3648 1379313
SGTC_435 c-PAF 6.7 µM -0.670889121045264 0.272046103515066 no 2447 0.251145583629189 3589 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase
SGTC_3061 glucosamine 200 µM -0.672328340758212 0.271633106830065 no 2448 0.250687345649531 3578 91431 and experimental redox chemotherapeutic
SGTC_1163 k060-0048 49.9 µM -0.672848936885949 0.271483794135407 no 2449 0.250521700428831 3650 6809982
SGTC_1491 4138-0063 26.5 µM -0.673376180620181 0.271332616515206 no 2450 0.250353999176329 3608 23883227
SGTC_786 4544-0069 423 µM -0.674383913238121 0.271043784157913 no 2451 0.250033633706174 3643 748821 YLR208W SEC13
SGTC_1100 amiodarone 5.07 µM -0.67444375224079 0.27102663816333 no 2452 0.250014617299329 3665 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death.
SGTC_501 nsc-95397 161 µM -0.675564560149573 0.270705586992023 no 2453 0.249658574415343 3651 262093
SGTC_3252 9135871 49.47 µM -0.675864793417221 0.270619618570551 no 2454 0.249563246181088 3665 17682838
SGTC_2205 7238770 200 µM -0.676924299102082 0.270316350034278 no 2455 0.249226992999239 3651 279867
SGTC_1302 1159-0335 255 µM -0.678489151464028 0.26986874415563 no 2456 0.24873079999624 3640 649284
SGTC_2444 5485484 36.41 µM -0.679645064133392 0.269538348648424 no 2457 0.248364614190992 3690 6790631
SGTC_1162 k048-0130 20.1 µM -0.679904393660498 0.269464252117284 no 2458 0.24828249972647 3632 6797406
SGTC_1936 st074407 74.3 µM -0.680126115932676 0.269400908958696 no 2459 0.248212304755857 3675 809813
SGTC_540 1187-0821 17.3 µM -0.68104291774544 0.269139069924681 no 2460 0.247922167203515 3640 847520
SGTC_1330 1469-0054 61.8 µM -0.681061640689071 0.269133723973815 no 2461 0.247916243895571 3664 7102664
SGTC_2506 ethyl hematommate 54.16 µM -0.681669811509858 0.268960102302909 no 2462 0.247723880238095 3624 3940691 An allergen.
SGTC_2443 5493264 126.67 µM -0.681919597336757 0.268888809300769 no 2463 0.247644896394965 3646 5340055
SGTC_2346 9031566 143.75 µM -0.683573105525694 0.268417110185065 no 2464 0.247122386145066 3620 4771086
SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM -0.685304944538552 0.267923512035613 no 2465 0.246575756150395 3637 803109
SGTC_3303 9125618 40.5795 µM -0.685320382799632 0.267919113973494 no 2466 0.246570886200458 3671 22695467
SGTC_1143 3454-2408 5.08 µM -0.68593253686502 0.267744752423986 no 2467 0.246377825697043 3610 X1143
SGTC_500 h-89 112 µM -0.686566355504702 0.267564280362567 no 2468 0.246178018045204 3680 449241 Protein kinase A inhibitor; also known to inhibit several other kinases.
SGTC_3076 9116187 49.47 µM -0.687805321736492 0.267211677173748 no 2469 0.245787692207541 3605 27241210
SGTC_398 bronopol 33.3 µM -0.688741427095922 0.266945422199927 no 2470 0.245493000614474 3607 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them.
SGTC_36 0335-0881 14.2 µM -0.690476334577135 0.266452319776072 no 2471 0.244947343620172 3611 23828853
SGTC_1508 1080-0625 72.9 µM -0.691671934804467 0.266112769832124 no 2472 0.244571687809725 3604 767111
SGTC_1157 4092-0394 27.6 µM -0.693372958163091 0.265630057865473 no 2473 0.244037764048673 3752 3659885
SGTC_1642 st009582 77.7 µM -0.695528800142846 0.265018917321616 no 2474 0.243361984446327 3670 6739311
SGTC_692 k241-0027 77.8 µM -0.695753704127488 0.264955202457753 no 2475 0.243291543362779 3709 3600480
SGTC_2634 4'-methoxyflavone 100 µM -0.696218325214091 0.264823600857751 no 2476 0.243146056556831 3660 77793 From seeds of Psoralea corylifolia (Fabaceae)
SGTC_998 3996-0085 177 µM -0.696863565150305 0.26464089500442 no 2477 0.242944090619631 3704 715391
SGTC_1150 3909-7983 10.9 µM -0.697566930768719 0.264441803373032 no 2478 0.242724034248726 3671 23965914
SGTC_1023 4482-3888 16 µM -0.698475080390422 0.264184859265026 no 2479 0.242440068413139 3669 3303168
SGTC_386 1509-0011 3.07 µM -0.699076170118562 0.264014862027932 no 2480 0.242252214990235 3706 3107280
SGTC_1827 berberine 7.24 µM -0.702377314235859 0.263082243483389 no 2481 0.241221944517478 3623 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_2619 obliquin 87.91 µM -0.702798002553698 0.262963514310922 no 2482 0.241090821102861 3659 6708593 A bioactive alkalod. YER133W GLC7
SGTC_506 n9-isopropylolomoucine 153 µM -0.704264892920734 0.262549734117991 no 2483 0.240633912574032 3681 6610355
SGTC_1129 3453-1384 223 µM -0.704620115007611 0.262449583273871 no 2484 0.240523338568052 3770 1084452
SGTC_2814 7977482 42.97 µM -0.705168512432617 0.26229500724599 no 2485 0.240352687025269 3736 6456762
SGTC_3082 9117008 49.47 µM -0.705307794596631 0.262255755401157 no 2486 0.240309355394447 3726 41448529
SGTC_2426 5582046 32.21 µM -0.7055005089502 0.262201450510195 no 2487 0.240249407664403 3677 2251934
SGTC_1106 tegaserod maleate 11.7 µM -0.705756062733188 0.262129447011244 no 2488 0.240169925017891 3719 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation.
SGTC_1757 st041620 31.8375 µM -0.707321459899783 0.261688610126509 no 2489 0.239683366218495 3714 5289815
SGTC_2539 epi(13)torulosol 80 µM -0.70800246054745 0.261496950005612 no 2490 0.239471864739917 3680 6708597
SGTC_717 1532-0246 73.2 µM -0.708169067752217 0.261450071220613 no 2491 0.239420136300473 3694 9561992
SGTC_2616 abietic acid 100 µM -0.708700558707372 0.261300552811615 no 2492 0.239255159031817 3678 6708678 Abietic acid is an inhibitor of 5α-reductase.
SGTC_1140 3229-1848 2.98 µM -0.709307586105296 0.261129838329763 no 2493 0.239066810903191 3709 2849525
SGTC_26 0302-0163 425.158 µM -0.709609932288778 0.261044830821229 no 2494 0.238973029341785 3714 3100915
SGTC_2628 lathosterol 100 µM -0.711942043767122 0.260389613895755 no 2495 0.2382503327718 3745 6710616
SGTC_2593 nobiletin 86.24 µM -0.713650365951918 0.259910191409582 no 2496 0.237721702545947 3672 72344 An anti-infammatory.
SGTC_250 brefeldin a 552.239 µM -0.714069135017935 0.259792737841924 no 2497 0.237592215194464 3597 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.
SGTC_739 1486-1183 203 µM -0.714333589099736 0.259718579627927 no 2498 0.237510463437208 3679 4346692
SGTC_2980 9014342 25.29 µM -0.714746028015003 0.259602945316859 no 2499 0.23738299535407 3701 2996599
SGTC_1406 3909-7906 11.9 µM -0.714935156253666 0.259549928867501 no 2500 0.237324556076412 3706 X1406
SGTC_1846 st056244 14.8 µM -0.715101190956388 0.259503390609595 no 2501 0.237273259049735 3715 5393182
SGTC_2151 5563267 85.4165 µM -0.715130721674384 0.259495113826503 no 2502 0.237264136064665 3724 5310824
SGTC_872 0588-0139 234 µM -0.716514830991676 0.259107332725309 no 2503 0.236836756544767 3712 2047100
SGTC_971 1315-0384 26.7 µM -0.716969734455481 0.258979949450383 no 2504 0.236696385822125 3723 6769120
SGTC_3277 9138724 49.47 µM -0.717131986031531 0.258934523171598 no 2505 0.236646330513457 3649 15943418
SGTC_649 1123-0311 367 µM -0.719821862743395 0.258182027732542 no 2506 0.235817341074937 3684 693629 YIL048W NEO1
SGTC_444 curcumin 90.4 µM -0.720871859218172 0.257888598219456 no 2507 0.235494179079802 3659 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties.
SGTC_845 0330-0138 4.51 µM -0.723255668640337 0.257223067448639 no 2508 0.234761411626286 3670 9039800
SGTC_576 1073-0113 22.7 µM -0.723435775299714 0.257172820150535 no 2509 0.234706099278166 3848 5439563
SGTC_1359 1582-0056 520 nM -0.723931378869643 0.257034579871579 no 2510 0.234553932239656 3775 3661189
SGTC_1004 4084-0029 199 µM -0.728012751239646 0.255897621216724 no 2511 0.233302890349875 3733 716894 YLR208W SEC13
SGTC_1810 st050138 53 µM -0.730913248839187 0.255091220191577 no 2512 0.232416071480225 3696 3444541
SGTC_2186 6124449 200 µM -0.732585718433491 0.254626842404387 no 2513 0.231905572126672 3693 3834182 YLR033W RSC58
SGTC_1667 st014849 34.6 µM -0.733868339931056 0.25427101002707 no 2514 0.231514492258935 3780 5348460
SGTC_1172 0370-0043 85 µM -0.734656659360651 0.254052439257744 no 2515 0.231274310943066 3755 376585
SGTC_2902 5787006 60.46 µM -0.734891073518198 0.253987464212242 no 2516 0.23120291760195 3702 591003
SGTC_1919 st067113 52.3 µM -0.73489623092044 0.25398603477868 no 2517 0.23120134699814 3766 1268243
SGTC_1120 ficusin 1.78878 µM -0.735582701670272 0.253795809166604 no 2518 0.230992346520358 3827 6199 A DNA cross-linker.
SGTC_79 0052-0007 94.094 µM -0.736770344387485 0.253466882192974 no 2519 0.230631010180134 3750 2801472
SGTC_2955 9076254 12.21 µM -0.73764802640238 0.253223945292471 no 2520 0.230364181416263 3679 16459619
SGTC_3230 9131665 49.47 µM -0.738420764446491 0.253010157626686 no 2521 0.230129400177884 3662 15943720
SGTC_2551 apiole 73.87 µM -0.738705367311139 0.252931442613551 no 2522 0.230042962945336 3599 10659 A possible DNA adduct former.
SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM -0.741050262724068 0.252283385991051 no 2523 0.229331482557667 3729 2333 A French combination drug.
SGTC_3176 9106582 49.47 µM -0.742907918110907 0.251770609629739 no 2524 0.228768715751498 3632 17018027
SGTC_2350 9023895 38.85 µM -0.743071465180528 0.251725491422171 no 2525 0.228719207197541 3759 2997209
SGTC_1123 mangostin 811.285 nM -0.743831908446439 0.251515761811633 no 2526 0.228489086772604 3758 5281650 An antioxidant.
SGTC_1912 st060209 90.8 µM -0.74402279125921 0.251463130993749 no 2527 0.228431343479309 3753 688787
SGTC_638 3970-0837 4.09 µM -0.744149269052714 0.251428261339224 no 2528 0.228393087640253 3735 4118451 YLR208W SEC13
SGTC_877 0771-0151 33.1 µM -0.746196923347483 0.250864083258436 no 2529 0.227774233202467 3782 6166523
SGTC_113 0099-0221 2.5 µM -0.747194799847419 0.250589387305421 no 2530 0.227472991296986 3751 89219
SGTC_1618 st003135 44.5 µM -0.748885235050046 0.250124407298118 no 2531 0.226963190134808 3676 1270615
SGTC_135 0933-0004 26.348 µM -0.7493389672823 0.249999679274407 no 2532 0.22682646341056 3750 21230617 YGL099W LSG1
SGTC_2048 5246248 200 µM -0.750919440001339 0.24956547548884 no 2533 0.226350570057593 3727 677046
SGTC_1372 2752-0194 270 µM -0.751138747137009 0.249505256838201 no 2534 0.226284579457469 3726 823334
SGTC_2563 tomatine 8.54 µM -0.751200558745195 0.249488285636023 no 2535 0.22626598200282 3703 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties.
SGTC_1977 st070720 65.3 µM -0.751491721750666 0.249408351196962 no 2536 0.226178390480102 3781 682188
SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM -0.751524926403731 0.249399236221919 no 2537 0.226168402632594 3763 66535 A nucleotide analog.
SGTC_973 1325-0077 65.9 µM -0.751793193187552 0.249325601078321 no 2538 0.226087718031387 3792 2835149
SGTC_736 0958-0254 92.6 µM -0.75204393781126 0.249256785952326 no 2539 0.226012318151134 3817 6812352
SGTC_2472 5377652 49.4 µM -0.754340818144441 0.248626893302765 no 2540 0.22532229917636 3821 1610903
SGTC_2810 7959871 45.46 µM -0.754859939491018 0.248484647888835 no 2541 0.225166512399022 3774 2974535
SGTC_2703 st077852 53.4 µM -0.756562753919448 0.248018361102489 no 2542 0.224655931394176 3753 6281836
SGTC_1832 st054113 55 µM -0.757026620606022 0.247891420055177 no 2543 0.224516957019519 3716 1251267
SGTC_2516 gossypol 71.55 µM -0.75827234514509 0.247550688670013 no 2544 0.224143979679 3803 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_3213 9129884 49.47 µM -0.758343201837979 0.24753131542488 no 2545 0.224122775345857 3755 17190742
SGTC_2351 9026858 72.31 µM -0.758946765398798 0.247366325256235 no 2546 0.223942201157331 3710 1409300
SGTC_1368 1852-0141 284 µM -0.7590281938395 0.247344070474232 no 2547 0.223917845721162 3748 2838987
SGTC_152 4469-0003 551.229 µM -0.759322506503711 0.247263642342389 no 2548 0.223829828671219 3715 697280
SGTC_2918 7977171 22.06 µM -0.759386657926998 0.24724611325368 no 2549 0.223810646177961 3709 2236483
SGTC_1169 aniline yellow 25.8 µM -0.759892786249215 0.247107839263366 no 2550 0.223659336974683 3705 6051 A DNA damaging agent.
SGTC_775 4577-0580 57.3 µM -0.760634407545899 0.246905303450606 no 2551 0.223437731242943 3838 2006902
SGTC_2840 9008771 71.43 µM -0.761442193271916 0.246684799345661 no 2552 0.22319649694767 3738 2992978
SGTC_176 1486-1328 72.834 µM -0.761829328925062 0.246579158961278 no 2553 0.223080936690107 3818 22310231
SGTC_2360 9040895 200 µM -0.763344914585945 0.246165823861226 no 2554 0.222628861242362 3805 4914414
SGTC_758 0868-0029 16 µM -0.764226765612916 0.245925493892927 no 2555 0.222366059429036 3841 762687
SGTC_1668 st014914 51.6 µM -0.764540670660666 0.24583997606474 no 2556 0.222272554815726 3784 2839556
SGTC_2024 5144227 134 µM -0.764658338695432 0.245807923622272 no 2557 0.222237510176323 3826 3475211
SGTC_16 erodoxin 22.806 µM -0.765586321537047 0.245555222327417 no 2558 0.221961242951034 3802 3967339 Erodoxin inhibits Ero1. YML130C ERO1
SGTC_653 0203-0016 55.2 µM -0.767619445889108 0.245002065379212 no 2559 0.221356653046976 3816 295302
SGTC_2247 cerulenin 830 nM -0.768255750313712 0.244829082367452 no 2560 0.221167628953349 3811 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12
SGTC_887 0885-0007 9.62 µM -0.769352701145628 0.244531024399818 no 2561 0.220841979627012 3856 5719458
SGTC_2029 5175081 200 µM -0.770234318499148 0.244291617511401 no 2562 0.220580454974627 3787 1380876
SGTC_402 epigallocatechin gallate 10 µM -0.770337325582889 0.244263653751553 no 2563 0.22054991033821 3767 65064 An antioxidant.
SGTC_1282 0886-0010 32.4 µM -0.770501545039874 0.244219075983684 no 2564 0.220501219440912 3857 2836211 YNL267W PIK1
SGTC_1311 1190-0148 100 µM -0.771029931224839 0.244075674043634 no 2565 0.22034459529223 3850 1961333
SGTC_1875 nocodazole 6 µM -0.772159336096738 0.24376931032823 no 2566 0.220010031216864 3756 4122 A microtubule depolymerizer. YJL014W CCT3
SGTC_416 estradiol valerate 100 µM -0.772516506025904 0.243672467206681 no 2567 0.219904287310515 3816 13791 A steroid.
SGTC_605 1315-0399 119 µM -0.77256223706612 0.243660069184167 no 2568 0.219890750262681 3879 24020461
SGTC_2009 4012297 12.05 µM -0.775054885203231 0.242984809410863 no 2569 0.219153614229919 3807 45595307
SGTC_1297 1068-0111 14.1 µM -0.776301613365669 0.242647450210585 no 2570 0.2187854603523 3748 767057
SGTC_1360 1598-0022 39.8 µM -0.777332593613331 0.242368663135821 no 2571 0.218481284994946 3865 761525
SGTC_1510 1123-0200 71.5 µM -0.778707571196066 0.241997126080269 no 2572 0.218075997565431 3829 5378812 YNL149C | YNL150W PGA2 | YNL150W
SGTC_1432 4049-0298 68.4 µM -0.779188005499716 0.241867379265335 no 2573 0.217934487318828 3799 741646
SGTC_2687 chenodiol 100 µM -0.781018561418398 0.241373362621697 no 2574 0.21739578893685 3835 5702181 A cholesterol synthesis inhibitor.
SGTC_2667 digitoxin 100 µM -0.781141830928077 0.241340115286835 no 2575 0.217359540675258 3769 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_114 0364-0001 490.298 µM -0.781891806822791 0.241137891000414 no 2576 0.217139080238377 3868 4003655
SGTC_931 2812-0076 566 µM -0.784818548497223 0.240349603208949 no 2577 0.216279981648345 3824 3450959
SGTC_1661 st013063 9.66 µM -0.785233861206822 0.240237856848456 no 2578 0.216158232819025 3846 721395
SGTC_951 1171-0579 82.7 µM -0.787136444005545 0.239726299396078 no 2579 0.215600998700626 3784 1616050 YPR165W | YDR526C RHO1 | YDR526C
SGTC_304 1310-0298 97 µM -0.787165089247329 0.239718601943833 no 2580 0.215592615366935 3739 1550234
SGTC_2361 9034121 116 µM -0.787727941496693 0.239567381560367 no 2581 0.21542792904034 3807 6496917
SGTC_2836 9010338 19.48 µM -0.789052366612119 0.239211756453311 no 2582 0.215040700256623 3812 2994051
SGTC_3342 9147791 14.508 µM -0.790323675383323 0.238870665283256 no 2583 0.214669381812825 3761 1838168
SGTC_1715 st032160 10.2275 µM -0.791088874899341 0.238665491143896 no 2584 0.214446065355654 3740 5289825
SGTC_1322 1348-1070 12 µM -0.791305933789345 0.238607308367639 no 2585 0.214382743312668 3766 6758089
SGTC_72 0744-0168 198.391 µM -0.79145629786948 0.238567007730287 no 2586 0.214338884354668 3733 677577
SGTC_1263 0774-1208 64.8 µM -0.791844557364207 0.238462963507017 no 2587 0.214225658993235 3812 906585
SGTC_1265 0819-1001 68.8 µM -0.791887050076892 0.238451577988652 no 2588 0.214213269257876 3788 3106768
SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM -0.792483233458459 0.238291867706395 no 2589 0.214039482134943 3887 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_1980 st071811 45.7 µM -0.792720428712303 0.23822834227766 no 2590 0.213970362676293 3942 4974850
SGTC_2268 7933382 153.85 µM -0.793122249806145 0.238120748072601 no 2591 0.213853300374323 3850 935025 YOR257W CDC31
SGTC_1638 st008370 60.6 µM -0.793946395123382 0.237900152956834 no 2592 0.213613319323318 3806 24207134
SGTC_2949 9072542 2.23 µM -0.794269961532432 0.237813576094616 no 2593 0.213519143646382 3900 16457352
SGTC_428 3448-4153 16.5 µM -0.795378224171665 0.237517168577099 no 2594 0.213196761491932 3803 3834874
SGTC_2235 salicylic acid 500 µM -0.79606282149956 0.237334172734154 no 2595 0.212997761117294 3827 338 A COX inhibitor and kinase inhibitor.
SGTC_165 k038-0023 64.381 µM -0.796681683480811 0.237168814885654 no 2596 0.212817962154025 3831 46368543
SGTC_857 0438-0306 1.35 µM -0.796706185101556 0.237162269437456 no 2597 0.212810845482579 3904 4686136
SGTC_320 4092-0846 5.34 µM -0.797838982675961 0.236859758339252 no 2598 0.212481968014975 3816 1359356
SGTC_291 SEC14.278 35.5 µM -0.798355126026705 0.236721993781209 no 2599 0.212332218118286 3812 1068044
SGTC_362 0310-0100 9.03 µM -0.798690812211741 0.236632418960497 no 2600 0.212234857796925 3903 790235
SGTC_1019 4262-0212 3.4 µM -0.799746166552917 0.236350928708198 no 2601 0.211928939454636 3876 4677213
SGTC_2434 5670830 169.91 µM -0.799905709365466 0.236308390567809 no 2602 0.211882714813938 3871 1549830
SGTC_2068 5226020 147 µM -0.800065652723273 0.236265749863654 no 2603 0.211836380043514 3882 1810509
SGTC_232 clozapine 119 µM -0.801005803654176 0.236015192442361 no 2604 0.211564143004248 3792 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_1097 itavastatin 7.23 µM -0.805415928879594 0.23484181686294 no 2605 0.210289851404418 3840 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49
SGTC_955 1216-0110 33 µM -0.806415841216747 0.234576225296769 no 2606 0.210001557962317 3801 3619719
SGTC_797 k781-0471 270 µM -0.806522619965857 0.234547873096434 no 2607 0.209970785380737 3817 23738129
SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM -0.806879251921038 0.234453192893893 no 2608 0.20986802677777 3876 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_3021 9087658 49.47 µM -0.80726463777724 0.2343509027574 no 2609 0.209757016370195 3783 25237042
SGTC_1795 st049545 62.3 µM -0.807303396535016 0.234340616672141 no 2610 0.209745853819788 3775 5291882
SGTC_2026 5148700 152 µM -0.807709598239868 0.234232830897829 no 2611 0.209628888446176 3831 79838
SGTC_2412 st077135 33.4 µM -0.809053403937654 0.233876447211273 no 2612 0.209242214409507 3942 13258915
SGTC_2167 5876490 200 µM -0.811626302734817 0.233194941273795 no 2613 0.208503046939728 4008 686534
SGTC_584 0986-0246 15.4 µM -0.81183680363628 0.233139232905601 no 2614 0.208442640401702 3941 53315 YDR232W HEM1
SGTC_2201 6605497 169.863 µM -0.811945723601392 0.233110410497417 no 2615 0.208411388160185 3809 670741
SGTC_2363 9053361 176 µM -0.81279806911366 0.232884931100663 no 2616 0.208166921391823 3903 6469797 YMR079W SEC14
SGTC_3266 9136860 49.47 µM -0.812829431559478 0.232876636794099 no 2617 0.208157929353505 3752 4871271 YPR165W RHO1
SGTC_864 0469-0573 172 µM -0.813302546357711 0.23275153383872 no 2618 0.208022308740959 3842 689425
SGTC_3052 9092717 49.47 µM -0.813684890470044 0.232650460133365 no 2619 0.207912746097669 3832 25237534
SGTC_1445 4239-0156 97.7 µM -0.815129849616187 0.232268701673777 no 2620 0.207498993550533 3950 4008346
SGTC_1956 st077085 54 µM -0.815787155016815 0.232095156879334 no 2621 0.207310940533629 3886 24208685
SGTC_910 3454-3003 490 µM -0.816368617203909 0.231941696746153 no 2622 0.20714467005572 3766 820824
SGTC_777 1315-0167 517 µM -0.81728735740846 0.231699337046027 no 2623 0.206882114982328 3906 4221767
SGTC_495 decylubiquinone 155 µM -0.82054501318267 0.230841119788272 no 2624 0.205952739728892 3892 2971 A Co-enzyme Q analog. A free radical scavenger.
SGTC_1680 diphenhydramine 100 µM -0.820666914302333 0.230809039887258 no 2625 0.205918010744816 3883 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1
SGTC_537 1334-0398 209 µM -0.821131576277458 0.230686780744647 no 2626 0.205785662868255 3825 5846986
SGTC_2065 5221596 34.26 µM -0.821857131375266 0.230495949301637 no 2627 0.20557910678048 3858 788581
SGTC_2420 aureobasidin a 50 nM -0.822115744307801 0.230427951710755 no 2628 0.205505512810793 3992 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1
SGTC_1938 st074717 56.4 µM -0.822183119680578 0.230410238417196 no 2629 0.205486342242825 3711 17250979
SGTC_2898 9056270 58.44 µM -0.823046708581816 0.230183264369172 no 2630 0.205240716095147 3819 19154699
SGTC_1505 k297-0037 20.6 µM -0.82306253192388 0.230179106742723 no 2631 0.205236217171366 3865 4089396
SGTC_2437 5741531 144.16 µM -0.823804527273192 0.229984192610258 no 2632 0.205025317391025 3900 2262990
SGTC_1625 st003711 30.1 µM -0.825239723276146 0.229607444447955 no 2633 0.204617752656386 3903 24207034 YER133W GLC7
SGTC_299 1273-0059 1.44 µM -0.825905211951214 0.229432866795211 no 2634 0.204428931910265 3788 2848077
SGTC_1134 3477-0009 42.5 µM -0.828291793820415 0.228807406901697 no 2635 0.203752634546819 3957 3973534
SGTC_648 0375-0473 33.3 µM -0.831642627968524 0.22793085953886 no 2636 0.202805346581219 3865 1713139
SGTC_465 cgp-37157 41 µM -0.833591993633584 0.227421793872749 no 2637 0.202255469412452 3829 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange.
SGTC_1417 3966-0327 90.4 µM -0.834906102956587 0.227078983467033 no 2638 0.201885289142955 3946 651118
SGTC_3166 9102297 49.47 µM -0.835599478077234 0.226898220860769 no 2639 0.201690131237765 3905 25237072
SGTC_3073 9114972 49.47 µM -0.835685315465704 0.22687584873632 no 2640 0.201665979241598 3841 41905075
SGTC_2348 9022543 33.42 µM -0.836841281021662 0.226574686281178 no 2641 0.201340894935859 3931 3162678 YDL140C RPO21
SGTC_265 mycophenolic acid 32.932 µM -0.840322865374051 0.225668997604554 no 2642 0.200363692225481 3953 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1
SGTC_635 k038-0028 24.7 µM -0.840342984174587 0.225663769920837 no 2643 0.200358053621676 3886 4035102
SGTC_2215 7188065 200 µM -0.84234571532582 0.225143721811774 no 2644 0.199797234538206 3896 940217
SGTC_669 0108-0021 26.2 µM -0.843485518734742 0.224848053104939 no 2645 0.199478480692739 3861 17201
SGTC_642 0335-0876 158 µM -0.844053879634428 0.224700700733559 no 2646 0.199319649109806 3921 6812350
SGTC_1540 guanosine 70.6 µM -0.844631195046934 0.224551082913426 no 2647 0.199158393126315 3778 6802 Guanosine is a purine nucleoside
SGTC_807 1315-0151 48 µM -0.845868973070458 0.224230489316175 no 2648 0.198812921425842 3871 4011080
SGTC_350 k064-0020 19.8 µM -0.846613692847875 0.22403772671681 no 2649 0.198605239589975 3873 2790705
SGTC_1939 st074455 53.6 µM -0.8474276349176 0.223827154391849 no 2650 0.198378403280772 3874 1644229
SGTC_1891 st059073 26.2 µM -0.85005800392202 0.223147429823576 no 2651 0.197646419306526 3973 688754
SGTC_2093 5331342 194.4 µM -0.851204322822663 0.222851572878413 no 2652 0.197327930957051 3978 33839
SGTC_1871 st057448 67.3 µM -0.851225030824696 0.222846230342853 no 2653 0.197322180390095 3936 691747
SGTC_1892 st058411 7.36 µM -0.852414435332082 0.222539493877984 no 2654 0.19699205548977 3934 3934738
SGTC_3045 9092950 49.47 µM -0.855216139089595 0.221817912510605 no 2655 0.196215751562963 3861 44120432
SGTC_3060 1327-0027 12.5 µM -0.855390260761869 0.221773111468048 no 2656 0.19616756674433 3839 16000455 YPR107C YTH1
SGTC_7 0192-1582 4.227 µM -0.85613758523236 0.221580885585302 no 2657 0.195960840594396 3950 252616
SGTC_622 1348-1566 26.3 µM -0.85632263197618 0.221533302802074 no 2658 0.195909673075742 3957 7340407
SGTC_2999 9069765 71.4286 µM -0.857117640588876 0.221328941335235 no 2659 0.195689936441532 3924 2097066
SGTC_1178 0988-0033 191 µM -0.858918446415521 0.220866432907207 no 2660 0.195192755774679 3976 5392207
SGTC_197 4544-0043 41.561 µM -0.859000930837157 0.220845261352933 no 2661 0.195170001226617 3900 896523
SGTC_1619 st003326 88.7 µM -0.865166668330556 0.219265973706494 no 2662 0.193473658533522 3905 2849032
SGTC_2329 6138490 200 µM -0.865878853469185 0.219083974240204 no 2663 0.193278300383554 4059 720019
SGTC_1793 st048256 72.231 µM -0.866001584037573 0.219052619125057 no 2664 0.19324464655965 3803 672022
SGTC_886 0866-0150 153 µM -0.866299501351121 0.218976518165397 no 2665 0.193162969835981 3988 271463
SGTC_1504 k297-0033 30 µM -0.867157612264009 0.218757404546222 no 2666 0.192927828767888 3847 4388117
SGTC_184 1494-0393 24.714 µM -0.867651501523343 0.218631350032902 no 2667 0.192792571662402 3925 3090647
SGTC_2475 5812728 15.03 µM -0.869471826483201 0.218167112817987 no 2668 0.192294555732482 3900 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2
SGTC_2452 5863136 48.41 µM -0.872445121809391 0.217410056819956 no 2669 0.19148279697431 3904 2184096
SGTC_1791 st048313 56.1 µM -0.873232589870172 0.217209807223618 no 2670 0.191268157353679 3915 1204976
SGTC_1561 5-methoxyflavone 52.9 µM -0.873319128529831 0.217187807329954 no 2671 0.191244578569078 3870 94525
SGTC_373 0844-0104 25.9 µM -0.87459359716936 0.216863960485803 no 2672 0.19089753643163 3992 5375804
SGTC_2570 licareol 100 µM -0.875140562859233 0.216725060290711 no 2673 0.190748714375767 3966 443158
SGTC_828 2074-0507 139 µM -0.876621520672796 0.216349234114207 no 2674 0.19034612304711 4030 X828
SGTC_2742 clothiapine 36.27 µM -0.883609316960301 0.214581021482455 no 2675 0.188453573904397 3895 16351 An atypical antipsychotic. YIL048W NEO1
SGTC_2196 6573537 42.6665 µM -0.885561256012778 0.214088602186518 no 2676 0.187926998567637 3971 2903087
SGTC_2246 7293507 91.5585 µM -0.885703660021337 0.214052703419346 no 2677 0.187888617773191 3998 887656
SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM -0.88581258027021 0.214025247971044 no 2678 0.187859264804305 3973 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair.
SGTC_2681 menadione 3.18 µM -0.887722352406991 0.213544186235642 no 2679 0.187345059619278 3974 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_439 amiodarone 34.4 µM -0.888847907932505 0.213260959963844 no 2680 0.187042412285522 3831 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1
SGTC_2973 9094665 17.96 µM -0.889004990661458 0.213221450280504 no 2681 0.187000198832889 4025 25237061 YIL048W NEO1
SGTC_198 3454-2873 16.191 µM -0.891775582435739 0.212525288794659 no 2682 0.186256615989942 3932 710957
SGTC_1691 st019933 84.6 µM -0.893046784698106 0.21220632099779 no 2683 0.185916059509196 3907 6176082
SGTC_1592 4',5'-dihydroxyflavone 8.85 µM -0.89365786279884 0.212053090023192 no 2684 0.185752488524722 3953 688669
SGTC_2747 doxorubicin 7.63 µM -0.893975059489999 0.211973576839071 no 2685 0.185667617767918 3872 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_512 prima-1 270 µM -0.897486578488725 0.211094493656056 no 2686 0.184729666024711 3978 322968 A re-activator of the apoptotic function of mutant p53.
SGTC_295 k015-0027 31 µM -0.898568926229937 0.210823967195277 no 2687 0.184441158164534 3989 3887424
SGTC_3291 9121177 71.43 µM -0.898746662490334 0.210779562504749 no 2688 0.184393808046178 3991 17015612
SGTC_2490 carminic acid 95.39 µM -0.90125986293253 0.210152265166876 no 2689 0.183725084475581 3900 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_2400 5203494 178.7 µM -0.901536627099816 0.21008325164884 no 2690 0.183651534300311 3893 6777674
SGTC_1805 st050013 60.3 µM -0.904633030980147 0.209312045016306 no 2691 0.182829915149591 3912 4037144
SGTC_772 k072-0172 35.3 µM -0.905691676008812 0.209048756022113 no 2692 0.182549534789612 4021 5861980
SGTC_1765 st044815 90.4 µM -0.906397949814972 0.208873211590285 no 2693 0.18236262878314 4021 645695
SGTC_1876 myriocin 605 nM -0.907189323238322 0.208676618849599 no 2694 0.182153344390131 3976 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1
SGTC_2985 9022375 71.43 µM -0.907369060874855 0.208631983684594 no 2695 0.18210583240902 4055 4939335
SGTC_459 nigericin 15.3 µM -0.907568642185024 0.20858242723368 no 2696 0.18205308401476 4032 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification.
SGTC_2035 5154463 94.595 µM -0.90781642030973 0.208520913071169 no 2697 0.181987610723793 4010 2769623
SGTC_2362 9071156 126 µM -0.907983638963265 0.208479404897916 no 2698 0.181943432919691 4026 653133
SGTC_3251 9135047 49.47 µM -0.91111005972451 0.207704240613545 no 2699 0.181118693267587 3983 17682963
SGTC_1418 3966-3099 2.4 µM -0.911882983976573 0.207512864722845 no 2700 0.180915159981492 3958 740335
SGTC_1898 st060199 18.6 µM -0.911954609084169 0.207495135638157 no 2701 0.180896306281169 3952 688866
SGTC_754 3474-0146 171 µM -0.913900288554445 0.207013871717494 no 2702 0.180384621018736 3950 24762078
SGTC_922 1866-0035 480 µM -0.913928179688212 0.207006977649359 no 2703 0.180377292666412 3933 3156169
SGTC_2965 9082772 38.63 µM -0.915218001227526 0.206688310871362 no 2704 0.180038598128614 4005 16459634
SGTC_490 phenamil 164 µM -0.916130871591072 0.206462950312582 no 2705 0.179799128761446 3966 4755 Irreversibly blocks amiloride-sensitive Na+ channels.
SGTC_1855 st056195 39.6 µM -0.916668770284354 0.206330227303169 no 2706 0.179658117833725 3948 4028379
SGTC_1118 chelidonine 707.474 nM -0.917692140296402 0.206077857052739 no 2707 0.179390031824292 3959 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor.
SGTC_2341 7987486 176.74 µM -0.919831698166212 0.205550818772847 no 2708 0.178830357982475 4024 1258686
SGTC_798 1287-0182 476 µM -0.92224633450113 0.204956982494979 no 2709 0.17820004974603 4036 1649755
SGTC_2075 5212009 200 µM -0.922527511336389 0.204887898482109 no 2710 0.178126743455301 3897 780898
SGTC_725 1497-0963 19 µM -0.923606500928994 0.204622923636417 no 2711 0.177845613951575 4082 3549977
SGTC_1008 4106-0037 6 µM -0.924114310391565 0.204498287987109 no 2712 0.177713401680629 3939 2905394
SGTC_1976 st070609 63.5 µM -0.92455873995414 0.204389245244726 no 2713 0.177597741774893 3895 682556
SGTC_1244 0416-0015 52.5 µM -0.92528280444463 0.204211666994642 no 2714 0.177409410462852 3973 96201
SGTC_1778 st046819 58.9 µM -0.92615490547579 0.203997904512393 no 2715 0.17718274186222 4065 671715
SGTC_2382 9035899 200 µM -0.926464942425398 0.203921942850559 no 2716 0.177102203959788 3990 6462679
SGTC_2819 7996655 46.38 µM -0.927478054234357 0.203673839490724 no 2717 0.176839190488189 3957 6456960
SGTC_2248 tofa 1.1 µM -0.927637548776782 0.203634796897372 no 2718 0.176797806690919 3939 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_196 k015-0023 18.111 µM -0.927797566693026 0.203595630672787 no 2719 0.176756293247247 3940 5211998
SGTC_3217 9129673 49.47 µM -0.928302434217428 0.203472087992372 no 2720 0.176625355875504 4029 17248312
SGTC_3271 9137798 49.47 µM -0.929403448281457 0.203202821518406 no 2721 0.17634002071898 3927 6498326
SGTC_2285 7945142 200 µM -0.930273158296463 0.202990273722691 no 2722 0.176114835858412 4061 2970608
SGTC_612 0302-0167 22.4 µM -0.930678114709448 0.202891352039442 no 2723 0.176010046895578 4024 235821
SGTC_1567 st069303 68.4 µM -0.931494738956232 0.202691956827296 no 2724 0.175798852383547 4081 5581319
SGTC_1615 st002656 86.5 µM -0.933551870813928 0.202190186086862 no 2725 0.175267550926291 4003 1584458
SGTC_1874 staurosporine 7.6 µM -0.934026518358027 0.202074516782552 no 2726 0.175145107040261 4055 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1
SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM -0.937787808171646 0.2011593097411 no 2727 0.174176733891138 4057 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis.
SGTC_1216 1165-0504 9.65 µM -0.940012777044866 0.200619096418039 no 2728 0.173605503413068 4063 6304004
SGTC_2641 levomentholum 100 µM -0.94054209372908 0.200490708868758 no 2729 0.173469784282022 3997 16666
SGTC_722 3534-0461 190 µM -0.943992451663009 0.199655022747011 no 2730 0.172586752795817 4075 658262
SGTC_894 0960-0238 55.9 µM -0.944666306450072 0.199492058254629 no 2731 0.172414631899596 4026 6741907 YDL195W SEC31
SGTC_2939 9044578 71.43 µM -0.945044030961568 0.199400744696064 no 2732 0.172318198660548 3972 2653634
SGTC_356 1634-0012 32.5 µM -0.945171191563652 0.199370009734857 no 2733 0.172285742244678 4034 735457
SGTC_2926 9010726 65.15 µM -0.945280341148231 0.199343630346176 no 2734 0.172257886064002 4068 2994293
SGTC_190 3970-0790 3.722 µM -0.946915777800052 0.198948627970389 no 2735 0.171840848708618 3922 2832352
SGTC_2309 7664088 163.95 µM -0.948500946566325 0.198566217186619 no 2736 0.17143724557846 4052 704922
SGTC_3261 9137475 49.47 µM -0.949395641511801 0.198350574221262 no 2737 0.171209713132409 3950 17027690
SGTC_2899 9053889 58.44 µM -0.949642812455435 0.198291025012461 no 2738 0.171146888435309 3989 6470052
SGTC_1789 tunicamycin 25 nM -0.950977381515878 0.197969682852792 no 2739 0.170807928967264 3953 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_109 0132-0036 33.701 µM -0.954938191022643 0.197017839007443 no 2740 0.169804477463684 3836 67274 A color developer.
SGTC_1250 0485-0349 40.2 µM -0.956326938361502 0.196684758489319 no 2741 0.169453542090261 4042 6842794 YDL195W SEC31
SGTC_2754 granisetron 64.02 µM -0.958399750708051 0.196188245106538 no 2742 0.168930610448823 4053 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients.
SGTC_1886 st057356 49.9 µM -0.959237967325026 0.195987677978319 no 2743 0.168719438817353 3997 24207747
SGTC_2449 5812982 45.77 µM -0.959983984552405 0.195809276832755 no 2744 0.168531637694577 3982 776185
SGTC_639 0833-0042 114 µM -0.960288820759126 0.195736407252619 no 2745 0.168454937433223 4045 5978911 YPR085C | YHR062C ASA1 | RPP1
SGTC_2479 5617353 43.85 µM -0.962657786409738 0.195170678976779 no 2746 0.167859643852466 4110 2731746
SGTC_1726 st035556 14.5795 µM -0.964233903413916 0.194794840507967 no 2747 0.167464335136037 4159 5919439
SGTC_1965 Pectolinarigenin 58.4 µM -0.964996622482783 0.194613121847823 no 2748 0.167273251745392 4020 5320438 An anti-inflammatory.
SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM -0.965551671957841 0.19448094556766 no 2749 0.167134284031736 4138 4213774
SGTC_139 0099-0334 718.624 µM -0.968545250718546 0.193769014499224 no 2750 0.166386065612333 4094 97690
SGTC_1267 0828-0272 9.49 µM -0.971169645134594 0.193146191419572 no 2751 0.165731903522279 4146 745334
SGTC_1743 st037606 46.3785 µM -0.971708158834355 0.193018542255892 no 2752 0.165597878350308 4030 590142 YLR208W | YDL195W SEC13 | SEC31
SGTC_1243 0416-0003 5.65 µM -0.973197976558815 0.192665664694179 no 2753 0.16522745815057 4062 2141977
SGTC_1711 st032263 62.8 µM -0.973640853325819 0.192560841166503 no 2754 0.165117447152781 4056 3958979
SGTC_1349 flufenamic acid 69 µM -0.974773384056483 0.192292943556448 no 2755 0.164836341186836 3979 3371 A non-steroidal anti-inflammatory.
SGTC_1774 st048371 48.465 µM -0.97481954888224 0.192282028207735 no 2756 0.164824889173496 4038 4242727
SGTC_1098 clofazimine 15.1 µM -0.976864893676061 0.19179880120851 no 2757 0.16431802194343 4123 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2
SGTC_1262 0737-0114 49.6 µM -0.977084043956745 0.191747069561802 no 2758 0.164263773211477 4147 765919
SGTC_710 3448-4187 58 µM -0.977839694144992 0.19156875964865 no 2759 0.164076807700205 4043 3946412
SGTC_1416 3966-0321 25.3 µM -0.978874602870899 0.191324718296733 no 2760 0.163820971185986 4092 582530 YLR208W SEC13
SGTC_1658 st012944 20 µM -0.982108478804098 0.190563368281348 no 2761 0.163023204409039 3936 24207260
SGTC_2828 7998861 71.43 µM -0.983521616985832 0.190231258556839 no 2762 0.162675390731912 4028 2988188
SGTC_1351 1496-0003 46.5 µM -0.984094227958434 0.190096787258941 no 2763 0.16253459234213 4090 3891978
SGTC_102 gallobenzophenone 83.616 µM -0.985244608800618 0.189826809774386 no 2764 0.162251966794848 4085 70837
SGTC_1835 st008666 49.2 µM -0.986288719334707 0.189581976584846 no 2765 0.161995726886936 4019 690455
SGTC_2676 harmalol 100 µM -0.988752093955677 0.189005110895438 no 2766 0.161392224093188 4023 5459187 A monoamine oxidase inhibitor
SGTC_2425 5628681 7.85 µM -0.989534938631486 0.188822013320339 no 2767 0.161200742186133 4147 5714958
SGTC_1476 4112-3294 3.34 µM -0.989537122982497 0.188821502580937 no 2768 0.161200208106618 4092 704369
SGTC_2905 7799065 20.05 µM -0.990620059731183 0.188568397905059 no 2769 0.160935569406802 4003 1296806
SGTC_117 lucigenin 22.078 µM -0.991840882906433 0.188283317292546 no 2770 0.160637575456266 4096 65100 An acridine derivative; a dye stuff and potential carcinogen.
SGTC_525 k781-2675 26.7 µM -0.992223746556542 0.188193967658825 no 2771 0.160544195536453 4043 3651118 YDL195W SEC31
SGTC_199 4063-0024 41.6 µM -0.994339773415031 0.187700618417902 no 2772 0.160028739187441 4099 306215
SGTC_478 N-arachidonylglycine 10 µM -0.996875593009619 0.187110448453184 no 2773 0.159412450002001 4024 5283389
SGTC_450 aminopyrene 156 nM -0.997621392483414 0.186937094642776 no 2774 0.159231491822749 3980 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1
SGTC_1027 k015-0025 8.67 µM -0.998694535634069 0.186687827429295 no 2775 0.158971344277613 4052 3598955
SGTC_2300 7976697 71.57 µM -0.998757242833405 0.186673268311772 no 2776 0.158956151638695 3977 2236109
SGTC_994 3910-0338 138 µM -0.998868302649036 0.186647484593864 no 2777 0.158929246510032 4169 3479481
SGTC_2971 9092186 9.93 µM -1.00010419483187 0.186360707884737 no 2778 0.158630043145984 4104 25236400
SGTC_2938 9059746 27.26 µM -1.00209010487051 0.185900468940017 no 2779 0.158150038270431 4086 6471769
SGTC_2781 5567276 71.43 µM -1.00403789431886 0.185449749840097 no 2780 0.157680174329026 4148 2853274
SGTC_2289 7946404 165.07 µM -1.00408886662943 0.185437963946137 no 2781 0.157667890638782 4112 1246120 YPR165W RHO1
SGTC_3284 9108171 64.8615 µM -1.00508880962556 0.185206849663972 no 2782 0.157427044000845 4079 8687505
SGTC_2502 avocadyne acetate 18.59 µM -1.00521358918755 0.185178022240379 no 2783 0.157397006528619 4024 3952079
SGTC_2816 7982706 58.44 µM -1.00869011176977 0.184375973080817 no 2784 0.156561637753316 4127 2981853
SGTC_1673 st016611 27.3 µM -1.0103216794566 0.184000309479343 no 2785 0.156170598872319 4131 5226799
SGTC_280 3448-3607 3.04 µM -1.0128676078495 0.183415069867618 no 2786 0.155561701177407 4080 626179
SGTC_1382 3002-2117 298 µM -1.01554758654726 0.182800270960737 no 2787 0.154922437458342 4182 1497314
SGTC_3202 9113761 49.47 µM -1.01635277535865 0.182615808699136 no 2788 0.154730712683207 4109 4798415
SGTC_1496 4469-0713 57.4 µM -1.01812180438267 0.18221094682624 no 2789 0.154310037196755 4089 746691
SGTC_2476 5806916 10.51 µM -1.01863864548711 0.182092767992307 no 2790 0.154187275161137 3972 2870194
SGTC_2439 5492030 7.2 µM -1.01979542975474 0.181828435990239 no 2791 0.153912745575435 4102 5722370
SGTC_1764 st044502 93.5 µM -1.01995660003473 0.1817916266934 no 2792 0.15387452211901 4151 8407
SGTC_487 nimodipine 119 µM -1.02045370729818 0.181678122912425 no 2793 0.153756666770301 4055 4497 L-type voltage-gated calcium channels inhibitor
SGTC_1151 3909-8316 15.3 µM -1.02066133333522 0.18163072909104 no 2794 0.153707460000903 4153 800431
SGTC_372 0155-0182 15.9 µM -1.02108744093616 0.181533487742646 no 2795 0.153606506390469 4020 771486
SGTC_3157 9099274 49.47 µM -1.02211727073899 0.18129860646857 no 2796 0.153362699955882 4145 17217662
SGTC_1654 st012436 41.8 µM -1.0235269012543 0.180977409783858 no 2797 0.153029393663566 4063 4323132
SGTC_2711 st079103 59.1 µM -1.02429406212278 0.180802755378979 no 2798 0.152848200865442 4071 54693780
SGTC_3096 9117468 49.47 µM -1.0250982683135 0.180619780588702 no 2799 0.152658411274002 3998 41316311
SGTC_1913 st060213 96.1 µM -1.02558367143997 0.180509396801343 no 2800 0.152543933676443 4162 688959
SGTC_189 3970-0742 2.116 µM -1.0263769866923 0.18032908293171 no 2801 0.152356960654845 4038 2891807
SGTC_1275 0867-0008 21.1 µM -1.02735253703819 0.180107503568114 no 2802 0.152127246066421 4087 3422836
SGTC_2763 lisinopril 49.32 µM -1.02780582861885 0.180004604422879 no 2803 0.152020586988179 3993 5362119 A lysine-analog of enalapril and an ACE inhibitor.
SGTC_358 0075-0058 9.45 µM -1.02982134609999 0.179547520357078 no 2804 0.151546939175741 3939 1069125
SGTC_1343 1487-0095 224 µM -1.03211228693248 0.179028861785262 no 2805 0.151009759275464 4137 4560101 YGL055W OLE1
SGTC_1946 st076057 65.1 µM -1.03380752687681 0.178645674690947 no 2806 0.150613076082282 4065 953009
SGTC_1844 rapamycin 4 nM -1.0338776270872 0.178629840571286 no 2807 0.150596687710837 4027 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2
SGTC_3306 9127676 59.7925 µM -1.03595367068926 0.178161307979067 no 2808 0.150111878455128 4125 41905287
SGTC_1587 estradiol valerate 56.1 µM -1.04074469796902 0.177083003244606 no 2809 0.148997026211615 4182 13791 A steroid.
SGTC_867 0518-0118 155 µM -1.04338181534967 0.176491236775758 no 2810 0.148385746116732 4112 6848158
SGTC_2664 lyso-paf C-16 73.48 µM -1.0436580913825 0.176429313181855 no 2811 0.148321802928491 4095 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_3341 9147222 25.867 µM -1.04369180009776 0.176421758763086 no 2812 0.148314002417934 4141 1939759
SGTC_288 1315-0019 35.1 µM -1.04385573886401 0.17638502156526 no 2813 0.148276069373858 4198 6811474
SGTC_1830 st055982 50.3 µM -1.04475279795029 0.176184084429141 no 2814 0.14806861789029 4094 455313 An antimicrobial agent.
SGTC_3078 9116413 49.47 µM -1.04701185812261 0.175678707412773 no 2815 0.147547054553875 4077 17177322
SGTC_2473 5854593 8.94 µM -1.04887119677588 0.17526344237111 no 2816 0.147118701863497 4024 2872951
SGTC_244 nsc-207895 1.295 µM -1.05075252373251 0.174843900554481 no 2817 0.146686132952386 3920 42640
SGTC_64 000l-0018 272.079 µM -1.05324107004 0.174289926999258 no 2818 0.146115259893807 4071 6811119
SGTC_263 alizarin 107.927 µM -1.05343223146857 0.174247418862667 no 2819 0.146071469228935 4162 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium.
SGTC_1785 bathophenanthroline 24 µM -1.05562857423414 0.173759495832557 no 2820 0.145568970464639 4058 72812 An iron chelator.
SGTC_1643 st009866 20.2 µM -1.0558330909533 0.173714106205749 no 2821 0.145522238546648 4085 3156273 YOR207C RET1
SGTC_2508 celastrol 40.54 µM -1.05719029554757 0.173413084759042 no 2822 0.145212373950717 4097 122724 Celastrol is a natural product and antioxidant.
SGTC_1136 pergolide 1.05886 µM -1.05855396385899 0.173110964321165 no 2823 0.144901481078655 4116 47811 A dopamine receptor agonist.
SGTC_847 0342-0274 5.54 µM -1.058846084269 0.173046288731105 no 2824 0.144834940985068 4157 18097
SGTC_1132 3456-3614 2.5 µM -1.06055540379979 0.172668153228791 no 2825 0.144445999354114 4218 3125502
SGTC_12 0849-0099 9.267 µM -1.06082021479171 0.172609618928306 no 2826 0.144385806810389 4049 6071388
SGTC_1251 0490-5699 265 µM -1.06114386393959 0.172538096118578 no 2827 0.144312263089195 4208 3883818
SGTC_801 0866-0028 10.1 µM -1.06162961796892 0.172430785433001 no 2828 0.144201931205888 4172 6849771
SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM -1.06303928171979 0.172119609685372 no 2829 0.143882068865756 4148 756377
SGTC_2891 9063876 19.48 µM -1.06488905761356 0.171711825624324 no 2830 0.143463068672697 4152 6472478
SGTC_1604 st002052 72.4 µM -1.06506539385696 0.171672984452517 no 2831 0.143423169089902 4236 6254834 YHR062C RPP1
SGTC_3204 9114183 49.47 µM -1.06717269397373 0.171209248763244 no 2832 0.142946930281957 4133 17027248
SGTC_3224 9130643 49.47 µM -1.06839812776905 0.170939946607562 no 2833 0.142670480602674 4222 17644395
SGTC_2831 7999036 19.48 µM -1.06885878674494 0.170838782005574 no 2834 0.142566652559588 4201 2988270
SGTC_1410 3909-8106 77.9 µM -1.06917587661009 0.170769168659684 no 2835 0.142495213293767 4217 1039210
SGTC_2318 6029776 164 µM -1.06939173990479 0.17072178880291 no 2836 0.142446593883072 4219 818325
SGTC_2784 7567673 72.73 µM -1.06968231053029 0.170658024713573 no 2837 0.142381165679883 4138 3471247
SGTC_3090 9117696 49.47 µM -1.0697133265986 0.170651219312481 no 2838 0.142374182948484 4121 7923821
SGTC_2505 galangin 7.89 µM -1.07024193585559 0.170535261046068 no 2839 0.142255211335641 4045 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_251 melphalan 456.522 µM -1.07294895269426 0.169942227803797 no 2840 0.141647010211229 4206 460612 A DNA alkylator.
SGTC_2837 9008476 45.46 µM -1.07414888671816 0.169679778538419 no 2841 0.141377978384217 4187 2992805
SGTC_284 0988-0104 32.6 µM -1.0759813091103 0.169279493504529 no 2842 0.140967807818037 4151 4666532
SGTC_2056 5235370 200 µM -1.07680548509339 0.169099653495155 no 2843 0.140783587176604 4104 5511916
SGTC_2104 5389443 200 µM -1.07763660605674 0.168918422346353 no 2844 0.140597979676652 4210 2244536
SGTC_1895 st058434 18.3 µM -1.08329724235037 0.167687405659611 no 2845 0.139338254468486 4193 5393175
SGTC_2052 5265182 7.135 µM -1.08439005558989 0.167450418950714 no 2846 0.139095945521652 4183 1239884
SGTC_1803 st050068 52.4 µM -1.08613119122073 0.167073283544489 no 2847 0.138710477198193 4235 3984059 YIL048W | YNL267W NEO1 | PIK1
SGTC_86 0417-1630 471.922 µM -1.08702025058596 0.166880921911924 no 2848 0.138513930100612 4187 3634867
SGTC_1930 st074634 34.3 µM -1.08835777245475 0.166591797786897 no 2849 0.138218597666641 4078 684253 YOR116C RPO31
SGTC_346 4513-0042 7.16 µM -1.09005508506699 0.166225365585099 no 2850 0.137844439868031 4157 2827372
SGTC_1096 rimcazole 32.2 µM -1.09167191217304 0.165876793899786 no 2851 0.137488667599021 4104 18528119 A dopamine reuptake inhibitor.
SGTC_1768 st044301 37.178 µM -1.09178692037042 0.165852017298952 no 2852 0.137463384698079 4183 3931349
SGTC_2886 9058944 51.95 µM -1.09516861538997 0.165124556832534 no 2853 0.136721386293156 4049 4949929
SGTC_1583 clindamycin 39.6 µM -1.09529165769998 0.16509812732806 no 2854 0.136694440552976 4162 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis.
SGTC_3205 9113483 49.47 µM -1.09721830028046 0.164684641438201 no 2855 0.13627298758869 4224 17018033
SGTC_2230 bromochlorosalicylanilide 954.5 nM -1.09766304244084 0.164589288614579 no 2856 0.136175826709375 4200 77254
SGTC_2583 asiatic acid 100 µM -1.10190932314789 0.163680686993948 no 2857 0.13525054748949 4239 5320556 A kinase inhibitor; arrests cells at G2/M.
SGTC_2369 9071472 200 µM -1.1019275050697 0.163676803515911 no 2858 0.135246594875364 4248 17296037
SGTC_2130 NSC 7 2.4545 µM -1.10335362452748 0.163372384908823 no 2859 0.134936813828895 4267 21448
SGTC_2552 juarezic acid 87.02 µM -1.10372454660136 0.163293268412794 no 2860 0.134856322118034 4158 1549512
SGTC_968 1309-0633 340 µM -1.10420412998284 0.16319101171143 no 2861 0.134752299265539 4234 3761976
SGTC_2707 st078556 66.6 µM -1.10511873308536 0.162996115540237 no 2862 0.134554072186229 4131 17250899
SGTC_3168 9103419 49.47 µM -1.10531809522036 0.162953652817089 no 2863 0.134510889892644 4199 16649256
SGTC_2255 7941087 197.44 µM -1.1057586794151 0.162859837015051 no 2864 0.134415492097427 4298 935561
SGTC_302 1094-0063 18.9 µM -1.10619898589793 0.162766115443064 no 2865 0.134320200854606 4171 5440289
SGTC_848 0368-0089 85.6 µM -1.10722142926043 0.162548618275443 no 2866 0.134099102370878 4209 762535
SGTC_1568 digitonin 820 nM -1.1083246957068 0.162314140398463 no 2867 0.133860806881741 4206 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1
SGTC_535 2293-4129 48.2 µM -1.10950407474785 0.162063729877499 no 2868 0.133606393796517 4210 396118 YIL048W NEO1
SGTC_2856 9022925 19.48 µM -1.11078194364826 0.161792691745797 no 2869 0.133331110212756 4252 4944862
SGTC_3321 9137793 26.8275 µM -1.11219107820449 0.16149415460001 no 2870 0.133028001551475 4176 4904192
SGTC_352 k048-0007 5.11 µM -1.11366024178521 0.161183282487347 no 2871 0.132712485912049 4172 6811911
SGTC_2311 7694451 200 µM -1.11482139829227 0.160937860474025 no 2872 0.132463482411667 4182 2163142
SGTC_1565 sinapyl alcohol 95.1 µM -1.1153950131383 0.160816711311851 no 2873 0.132340592800028 4236 5280507 A phenol propionate derived from cinnamic acid.
SGTC_2605 digitonin 300 nM -1.12138819028548 0.159554496432973 no 2874 0.131061330434609 4246 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_2997 9067075 71.4286 µM -1.12309783226549 0.159195622982764 no 2875 0.130697973344743 4229 27209819
SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM -1.12377166676975 0.159054322762425 no 2876 0.130554952098885 4245 6728940
SGTC_2080 5212524 12.4 µM -1.1282183799883 0.158123926881946 no 2877 0.129613851734707 4152 260183
SGTC_2989 9073649 71.4286 µM -1.1300759026182 0.157736333123107 no 2878 0.129222121340818 4176 21367202
SGTC_2705 st078069 42.8 µM -1.13052093164471 0.157643565373084 no 2879 0.129128391770795 4278 1530061
SGTC_1067 clotrimazole 1.36 µM -1.13220077283155 0.157293720075393 no 2880 0.128775017643277 4257 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_3086 9117350 49.47 µM -1.1335405123526 0.157015070817283 no 2881 0.128493669167498 4159 2679265
SGTC_1541 2',3',6-trimethoxyflavone 64 µM -1.13384156761495 0.156952499752496 no 2882 0.128430505602954 4317 688801
SGTC_1748 st037455 53.6035 µM -1.1342824896363 0.156860888511452 no 2883 0.128338035889923 4275 580690
SGTC_164 4100-3994 89.624 µM -1.1384070365007 0.156005627496976 no 2884 0.127475278605963 4206 4615967
SGTC_1974 st069448 26.9 µM -1.13872074708125 0.155940702862292 no 2885 0.127409823242072 4223 6323587 YNR016C ACC1
SGTC_3181 9108277 49.47 µM -1.14112885562282 0.155442920849239 no 2886 0.126908152434091 4190 17097298
SGTC_1298 1079-1278 263 µM -1.14494930852202 0.154655345416386 no 2887 0.126115078273557 4208 2840950
SGTC_2133 5320837 200 µM -1.14588166452957 0.15446354387733 no 2888 0.125922059417521 4265 2841355
SGTC_2229 7354935 190 µM -1.14603960209538 0.154431069006544 no 2889 0.125889383171831 4172 318112
SGTC_49 0717-0965 32.132 µM -1.14639837671891 0.154357315113854 no 2890 0.1258151770327 4317 5889349 YGL099W LSG1
SGTC_1388 3346-4487 254 µM -1.14734820908967 0.154162168967854 no 2891 0.125618868450361 4306 3345614
SGTC_651 3253-0966 34.4 µM -1.14788154117446 0.154052665730176 no 2892 0.125508734671503 4255 781462
SGTC_1006 4099-6547 255 µM -1.14917331335722 0.153787653602626 no 2893 0.125242261330976 4264 3146833
SGTC_1790 st045711 43.5 µM -1.15006155826062 0.153605601872717 no 2894 0.125059259007364 4247 585119
SGTC_987 1497-1013 404 µM -1.15580635085957 0.152431615472396 no 2895 0.123880187374193 4264 1676435
SGTC_1818 st052136 56.3 µM -1.15595423227523 0.152401473752438 no 2896 0.123849938996593 3935 674169
SGTC_227 fluconazole 33.516 µM -1.15698904997583 0.152190664199442 no 2897 0.123638417060684 4238 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C
SGTC_2523 spermine 47.74 µM -1.15707094758751 0.152173988567647 no 2898 0.123621687586469 4284 1103 A DNA binding polyamine.
SGTC_1167 k781-0610 148 µM -1.1633530171968 0.150898476700194 no 2899 0.122343151685807 4284 4525169
SGTC_1884 5633444 25 µM -1.16580191168466 0.150403186328578 no 2900 0.121847272067258 4234 5724239
SGTC_1403 3909-7815 62.9 µM -1.1671190439094 0.15013724399443 no 2901 0.121581149078713 4213 6615483
SGTC_2770 toltrazuril 17.5 µM -1.16731722363153 0.150097256648739 no 2902 0.121541142788864 4204 68591 Kills coccidiodes.
SGTC_2740 felodipine 17.08 µM -1.16808541697062 0.149942322968532 no 2903 0.121386156022638 4291 3333 L-type calcium channel blocker
SGTC_1934 st074720 32.6 µM -1.16822056140765 0.14991507729123 no 2904 0.121358904350708 4199 17250992
SGTC_477 mead ethanolamide 10 µM -1.16878315886328 0.149801690800198 no 2905 0.121245503652698 4187 16061185
SGTC_24 0417-1663 219 µM -1.16998493828474 0.149559674548047 no 2906 0.121003515068808 4279 4329390
SGTC_2109 5483026 200 µM -1.17142860848905 0.149269291119674 no 2907 0.120713269246414 4272 759335
SGTC_3177 9107506 49.47 µM -1.17413608169921 0.148725718867543 no 2908 0.120170261573121 4212 8897194
SGTC_1016 4226-1401 38 µM -1.17442977781589 0.148666833919203 no 2909 0.120111461865371 4245 2901613
SGTC_4 0960-0234 25.671 µM -1.17839313046838 0.147873721181707 no 2910 0.119319957544145 4277 6821112
SGTC_1701 st028638 40.4 µM -1.1813619122523 0.147281492544283 no 2911 0.118729490926328 4279 3490878
SGTC_588 3970-1144 52.9 µM -1.18136360719752 0.147281154882153 no 2912 0.118729154406127 4143 1888707
SGTC_1553 gossypol 38.6 µM -1.18197635103772 0.1471591198084 no 2913 0.118607542305919 4150 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_1430 4049-0248 69.1 µM -1.18225639476148 0.147103368415607 no 2914 0.118551990964941 4280 22774488
SGTC_1043 0916-0009 19.3 µM -1.18272002488159 0.147011099587825 no 2915 0.118460062624382 4295 3101130
SGTC_558 k064-0027 21.3 µM -1.18291206058406 0.146972893187346 no 2916 0.118422000644634 4264 5088526
SGTC_2395 5646831 180.19 µM -1.18461495751536 0.14663438523766 no 2917 0.118084860180985 4287 6808628
SGTC_2639 lactacystin 53 µM -1.18881082089653 0.145802550801981 no 2918 0.117257059472421 4317 3870 A proteasome inhibitor.
SGTC_1176 0848-0131 83.3 µM -1.19170520248357 0.145230588635762 no 2919 0.116688428710965 4328 6769040
SGTC_1238 0333-0287 48.8 µM -1.19208247116943 0.145156147494087 no 2920 0.116614454714055 4256 7226
SGTC_2843 9000894 45.46 µM -1.19316304549609 0.144943075027578 no 2921 0.116402762176332 4214 2242070
SGTC_2032 5185112 25.99 µM -1.19504643012904 0.144572204403094 no 2922 0.1160344450803 4163 5718189
SGTC_591 4299-0174 154 µM -1.19664096039598 0.144258714319655 no 2923 0.11572326402662 4306 5509088
SGTC_1656 st012921 11 µM -1.19871884547051 0.14385088315589 no 2924 0.115318643832693 4180 6732821
SGTC_1044 1222-0021 1.78 µM -1.19953824852864 0.143690271129057 no 2925 0.115159360761675 4227 4306703
SGTC_272 doxorubicin 8.13 µM -1.20557000085134 0.142511705926225 no 2926 0.113991666017602 4298 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_2933 9026794 32.47 µM -1.20577050073022 0.142472642150822 no 2927 0.113952996380024 4237 17586027
SGTC_2402 5553605 200 µM -1.20592141076011 0.142443244838143 no 2928 0.113923897110737 4369 6758546
SGTC_1059 3448-6867 171 µM -1.21085779588922 0.141483897635343 no 2929 0.112974954992458 4249 3934407
SGTC_1617 st002906 78 µM -1.21211968714671 0.141239363403241 no 2930 0.112733284333714 4277 5150859
SGTC_730 1436-0052 41.2 µM -1.21319797704794 0.141030635315807 no 2931 0.112527068695558 4333 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2
SGTC_90 0870-0863 4.608 µM -1.21363258039505 0.140946566912386 no 2932 0.112444029982572 4318 1738164
SGTC_505 gw-5074 63.9 µM -1.21397154462012 0.140881022261262 no 2933 0.11237929522189 4323 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases.
SGTC_564 3555-0129 330 µM -1.21468032804947 0.140744033443689 no 2934 0.112244019137799 4183 563260
SGTC_1948 st076329 66.6 µM -1.21895459221936 0.139919849253908 no 2935 0.111430713717618 4218 24208413
SGTC_548 1436-0017 110 µM -1.22315362340068 0.13911337185392 no 2936 0.110635839117159 4359 9677137
SGTC_1712 st032288 53.4 µM -1.22352552781969 0.139042095706153 no 2937 0.110565634190132 4147 2883011
SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM -1.22725639105093 0.138328444689286 no 2938 0.109863120301634 4219 4330530
SGTC_417 st075190 100 µM -1.22811836644378 0.13816391907588 no 2939 0.109701268670853 4305 222757
SGTC_2556 citropten 84.59 µM -1.22918027254373 0.1379614161078 no 2940 0.109502111822815 4338 2775 A potential DNA crosslinker.
SGTC_2185 6113692 200 µM -1.23332443041663 0.137173072365889 no 2941 0.108727373333346 4311 874150
SGTC_946 3434-1334 87.4 µM -1.23353597764846 0.137132912423984 no 2942 0.108687931195805 4292 4047976
SGTC_785 1270-0111 65.3 µM -1.24337291628609 0.135274343526474 no 2943 0.106865222919607 4246 6741994
SGTC_57 miconazole 162.5 nM -1.24441950967401 0.135077623722655 no 2944 0.106672603104995 4181 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_1800 st050079 29.0735 µM -1.24689542002187 0.134613027923122 no 2945 0.106217923151504 4153 3645560
SGTC_3186 9110464 49.47 µM -1.25020374800714 0.13399394553728 no 2946 0.105612564018531 4322 17018021
SGTC_2959 9079155 11 µM -1.25342346369817 0.133393326235663 no 2947 0.105025818380989 4346 16189457
SGTC_2262 9014885 67.46 µM -1.25493631387304 0.133111753303207 no 2948 0.104750940038618 4332 6457424
SGTC_1637 st007924 17.4 µM -1.25604284855106 0.132906063349966 no 2949 0.104550217620098 4237 683336
SGTC_2069 5228469 200 µM -1.26086288500658 0.132012636675345 no 2950 0.10367912614598 4337 2835210
SGTC_3032 9089427 49.47 µM -1.26089518315086 0.132006663997296 no 2951 0.103673306943196 4327 17173707
SGTC_2288 7946289 167.31 µM -1.26183029470591 0.13183382092503 no 2952 0.10350492929861 4371 1246052
SGTC_917 harmaline 728.087 nM -1.26347452873473 0.131530284638641 no 2953 0.103209347416254 4285 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7
SGTC_659 k018-0002 107 µM -1.26437150158274 0.131364901138636 no 2954 0.103048358360736 4304 6797879 YHR007C ERG11
SGTC_415 dibenzyl ketone 100 µM -1.26459075628736 0.13132449689027 no 2955 0.103009034192643 4313 7593
SGTC_3155 9099265 49.47 µM -1.26505782698877 0.131238453733165 no 2956 0.10292529962649 4327 25236499
SGTC_2491 paeonol 100 µM -1.26671677954544 0.130933158420091 no 2957 0.102628289006463 4275 11092 Increases levels of cortical cytochrome oxidase.
SGTC_468 gf-109203x 121 µM -1.27174626231655 0.130010588695889 no 2958 0.101731643833592 4371 2396 A protein kinase C inhibitor.
SGTC_443 clozapine 122 µM -1.27452323883606 0.12950313398341 no 2959 0.10123902109171 4312 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_3118 9124250 49.47 µM -1.27560783723162 0.129305311509072 no 2960 0.101047091136387 4307 1504786
SGTC_941 3237-0776 460 µM -1.27624074872107 0.129189970096328 no 2961 0.10093521406833 4382 760008
SGTC_890 0929-0006 47.2 µM -1.27624370966163 0.129189430663953 no 2962 0.10093469088779 4338 1378169
SGTC_2147 5545932 89.7195 µM -1.2765779427147 0.129128549193628 no 2963 0.100875646606988 4382 797404
SGTC_1825 st052143 62.6 µM -1.27974280593568 0.128553046523798 no 2964 0.100317802314599 4389 674173
SGTC_1422 4031-0024 15.5 µM -1.28578553593745 0.127459178809889 no 2965 0.0992589597550159 4290 782427
SGTC_1435 4092-0789 56.7 µM -1.29081505082546 0.126553674419785 no 2966 0.0983839087694476 4348 2248285
SGTC_128 0906-2981 13.371 µM -1.29106743904573 0.126508353290229 no 2967 0.0983401467949429 4335 6740226
SGTC_2854 9024559 71.43 µM -1.2912089545312 0.126482946427254 no 2968 0.0983156154497659 4370 3163529
SGTC_2331 7980721 200 µM -1.29230775734284 0.126285794743853 no 2969 0.0981252932948723 4314 2981221
SGTC_216 k038-0035 28.382 µM -1.29348029738368 0.12607564913563 no 2970 0.0979224970668642 4276 4444231 YPR107C YTH1
SGTC_2866 9034245 58.44 µM -1.29505618026028 0.125793599590286 no 2971 0.0976504249000106 4368 6462273
SGTC_2127 5253358 187.912 µM -1.29730022484104 0.125392723373657 no 2972 0.09726395353544 4269 20612
SGTC_2650 prasterone 100 µM -1.29947063897532 0.12500584964915 no 2973 0.0968912316559519 4355 16759247 A steroid and weak partial agonist of the androgen receptor.
SGTC_292 k038-0015 474 µM -1.30146290782047 0.124651464724153 no 2974 0.0965500264551366 4360 46368540
SGTC_3197 9113331 49.47 µM -1.30407047536037 0.124188692306215 no 2975 0.0961047772100604 4359 16610459 YLR208W | YDL195W SEC13 | SEC31
SGTC_1219 1469-0211 33.1 µM -1.30602885862348 0.123841923677702 no 2976 0.0957713719295412 4377 6822282
SGTC_2994 9053520 71.4286 µM -1.30947591103477 0.123233205748138 no 2977 0.0951865961799525 4407 4647384
SGTC_2121 5257820 149.641 µM -1.30996240412318 0.123147464647028 no 2978 0.0951042771726244 4410 791256
SGTC_1678 st019265 80.2 µM -1.31085266693923 0.122990670156388 no 2979 0.0949537724815028 4360 5367020
SGTC_2212 7123476 200 µM -1.311384979493 0.12289698531841 no 2980 0.0948638654624265 4382 1085715
SGTC_3174 9107204 49.47 µM -1.31240941116701 0.122716830359576 no 2981 0.0946910165894369 4398 3938802
SGTC_3232 9132874 49.47 µM -1.31883239314428 0.121591516149462 no 2982 0.0936125760676541 4341 3784940
SGTC_808 0711-0032 135 µM -1.32007012074526 0.121375500911095 no 2983 0.0934058037854249 4352 4252555
SGTC_1472 k841-0093 193 µM -1.32210212547274 0.121021449312477 no 2984 0.0930670730645961 4497 X1472
SGTC_1199 1638-0010 4.46 µM -1.32246074105156 0.120959040509554 no 2985 0.0930073870112924 4363 3111136
SGTC_2150 5556613 200 µM -1.32312133850017 0.120844137984795 no 2986 0.0928975147902512 4415 743190
SGTC_1544 7-methoxy-4-methylcoumarin 105 µM -1.32370891636455 0.120742000856599 no 2987 0.0927998680328721 4392 390807
SGTC_855 0428-0020 25 µM -1.32422944647636 0.120651569237995 no 2988 0.0927134270400975 4403 6812414
SGTC_3340 9146634 11.102 µM -1.32661291378528 0.120238098900529 no 2989 0.0923183809062942 4374 4907387
SGTC_577 r071-0003 38.6 µM -1.32763118081005 0.120061760436999 no 2990 0.0921499892587796 4347 4568517 YMR134W ERG29
SGTC_1248 0469-0687 58.6 µM -1.32837025711708 0.119933885052473 no 2991 0.0920279100969026 4359 4017482
SGTC_2708 st078559 56 µM -1.3284184134492 0.11992555635066 no 2992 0.0920199598868528 4334 17250902
SGTC_1119 parthenolide 318.541 nM -1.33110231925179 0.119462015716089 no 2993 0.0915776729795709 4442 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs.
SGTC_1115 galangin 695.678 nM -1.33472184207099 0.118838887535635 no 2994 0.0909837010500231 4464 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_3119 9125183 49.47 µM -1.34102993077109 0.117758396437331 no 2995 0.0899553675166074 4238 22695334
SGTC_2864 9034755 47.6 µM -1.34149243100943 0.117679450780252 no 2996 0.089880312772514 4321 4930451
SGTC_865 0488-0499 301 µM -1.34181340003166 0.117624685566458 no 2997 0.089828253141498 4341 9634651
SGTC_1634 st006576 41 µM -1.34348136424762 0.117340380297256 no 2998 0.0895580781966952 4378 3915356
SGTC_769 0302-0231 76 µM -1.34358341088187 0.117323002213249 no 2999 0.0895415684364458 4296 571869 YER009W NTF2
SGTC_2716 st080858 38.6235 µM -1.34542727377842 0.117009314613675 no 3000 0.0892436462528071 4369 5296050
SGTC_1455 4262-0120 131 µM -1.34675687351134 0.11678348526801 no 3001 0.0890292742547765 4459 1529587
SGTC_902 1120-0002 2.07 µM -1.34964313945137 0.116294323686809 no 3002 0.0885652397072787 4395 3280475
SGTC_3016 9080866 49.47 µM -1.34980363063862 0.116267166524756 no 3003 0.0885394899836915 4357 17066299
SGTC_2717 st081029 62.2815 µM -1.35278988374176 0.115762674961871 no 3004 0.088061382748613 4381 5292846
SGTC_881 0833-0569 170 µM -1.36026913931686 0.114505973003356 no 3005 0.086872385228251 4422 5418700
SGTC_1488 4013-0813 75.9 µM -1.36121114778548 0.114348383231924 no 3006 0.0867234861284916 4384 2910057
SGTC_762 1165-0429 115 µM -1.36223538992711 0.114177211785904 no 3007 0.0865618052320305 4398 5967793
SGTC_97 0535-0701 19.132 µM -1.36357226364437 0.113954067978035 no 3008 0.0863511132575162 4311 2832013 YGL099W LSG1
SGTC_2298 7976326 193.81 µM -1.3657302363447 0.113594526632327 no 3009 0.0860118251529803 4349 2235818
SGTC_829 1635-0120 117 µM -1.36730068712932 0.113333381681764 no 3010 0.0857655382118761 4414 285054
SGTC_2315 7733312 200 µM -1.36756910656579 0.113288790006378 no 3011 0.0857234960407325 4312 726316
SGTC_731 3966-0296 387 µM -1.37030514925788 0.112834973710618 no 3012 0.0852958331735145 4414 660956
SGTC_2651 TUB2.036 5 µM -1.37074444827423 0.112762230055489 no 3013 0.085227316804963 4339 15992207 YFL037W TUB2
SGTC_705 1124-0212 310 µM -1.37086432942713 0.112742384716637 no 3014 0.08520862640557 4405 9554485
SGTC_182 3448-4371 550.524 µM -1.37115773474263 0.112693824401317 no 3015 0.085162895203327 4325 3491403
SGTC_44 0929-0055 61.211 µM -1.3715669262381 0.112626125731289 no 3016 0.0850991478668277 4293 1379590
SGTC_2339 9000433 200 µM -1.37202208101777 0.112550856795268 no 3017 0.0850282819971738 4405 2988954
SGTC_2101 5377231 179.231 µM -1.37217750618011 0.112525162370955 no 3018 0.0850040930236336 4447 2844213
SGTC_2709 st078560 56 µM -1.37669702024155 0.111779841369798 no 3019 0.0843029701978822 4396 17250903
SGTC_1754 st042065 16.137 µM -1.37682337587688 0.111759054701102 no 3020 0.0842834309026164 4180 1126236 YIL048W NEO1
SGTC_3170 9103054 49.47 µM -1.37720533886369 0.111696235075496 no 3021 0.0842243858407526 4396 16432970
SGTC_1207 2099-0101 141 µM -1.38043518893269 0.111166046793515 no 3022 0.0837263459402569 4423 5837381
SGTC_2640 pentamidine 10.38 µM -1.38220993463591 0.110875485965121 no 3023 0.0834536252927792 4392 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_390 dec-rvkr-cmk 16.7 µM -1.38253279378989 0.1108226861073 no 3024 0.0834040842066167 4462 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1
SGTC_2669 eugenol 100 µM -1.38447846457306 0.110504875674503 no 3025 0.083105998881847 4442 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism.
SGTC_3084 9116877 49.47 µM -1.38546618031191 0.110343790123138 no 3026 0.0829549834121653 4375 27241325
SGTC_1950 st077106 7.18 µM -1.39311442010839 0.109102144372359 no 3027 0.0817925965927826 4341 13831864
SGTC_1397 3532-0190 20.1 µM -1.39313953195549 0.109098084220606 no 3028 0.0817888003956463 4376 5322280
SGTC_256 clotrimazole 625 nM -1.39423430842409 0.108921183327274 no 3029 0.0816234303967072 4366 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C
SGTC_1644 st010134 20.9 µM -1.39574267865858 0.108677789253477 no 3030 0.0813959986588617 4408 3818134
SGTC_597 k018-0003 82.8 µM -1.39653531261856 0.108550044917506 no 3031 0.0812766772257515 4489 6786234
SGTC_1310 1188-0297 994 nM -1.40193458979422 0.107682747138672 no 3032 0.080467390096212 4311 1588352
SGTC_1685 st024049 53.0905 µM -1.40286553243075 0.107533713792975 no 3033 0.0803284703784137 4447 1941139
SGTC_1995 st072814 61.1 µM -1.4029937783131 0.107513194737888 no 3034 0.0803093471252895 4421 5769371
SGTC_2076 5212012 200 µM -1.40388422824027 0.107370802544162 no 3035 0.0801766634582392 4407 604802
SGTC_2084 5306078 60.6385 µM -1.40390320947745 0.107367768727655 no 3036 0.0801738369173759 4381 679340
SGTC_335 4077-0256 27.6 µM -1.40416538458064 0.107325870975341 no 3037 0.080134803508031 4369 3121989
SGTC_2220 6782180 200 µM -1.40490862789314 0.107207158612659 no 3038 0.0800242253202541 4373 833803
SGTC_252 miconazole 1.30953 nM -1.41215509494377 0.106054696944831 no 3039 0.0789521496328444 4345 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_2576 guaiol 23.12 µM -1.41260141803317 0.105984008505964 no 3040 0.0788864759413896 4338 227829
SGTC_1531 st059297 52.4 µM -1.4139974657016 0.105763122949901 no 3041 0.0786813232945491 4468 7566702
SGTC_3349 9149703 23.001 µM -1.41809893240197 0.105116105880794 no 3042 0.0780809414617225 4462 4910494
SGTC_2919 7978188 46.38 µM -1.41838611157687 0.105070910162681 no 3043 0.0780390340849352 4457 2980291
SGTC_115 0527-0192 112.043 µM -1.41849676585597 0.105053499354726 no 3044 0.0780228911232143 4430 4233931
SGTC_2164 5685496 200 µM -1.41930771592652 0.104925964799496 no 3045 0.0779046617951107 4361 759046
SGTC_939 1165-0479 45.3 µM -1.4248820340791 0.104052348651295 no 3046 0.0770956518920746 4422 1377347
SGTC_294 k038-0071 157 µM -1.42516669668458 0.104007877832666 no 3047 0.0770545103285761 4471 24152826
SGTC_1562 morin hydrate 59.1 µM -1.42657445850742 0.103788155796637 no 3048 0.0768512953426598 4451 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase.
SGTC_790 1575-0012 79.1 µM -1.42688194957366 0.103740207741702 no 3049 0.0768069622761602 4492 378741 YLR208W SEC13
SGTC_492 tmb-8 126 µM -1.42709033113745 0.103707723281588 no 3050 0.0767769295521734 4482 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1
SGTC_747 3448-8087 38.7 µM -1.43087962143719 0.103118300135339 no 3051 0.0762323592302835 4497 5168703
SGTC_1616 st002734 56.1 µM -1.4321459874565 0.102921860662386 no 3052 0.0760510228505659 4409 4026101
SGTC_1603 st002045 67.8 µM -1.43344219321101 0.102721074132914 no 3053 0.0758657538708823 4445 5887985
SGTC_1105 epirubicin 18.1 µM -1.43364423141427 0.102689803413537 no 3054 0.0758369071824006 4495 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM -1.4356008690534 0.102387320242925 no 3055 0.0755579736568893 4456 2724278 An inhibitor of dopamine biosynthesis.
SGTC_751 0833-0568 350 µM -1.43810715161126 0.102000812813757 no 3056 0.0752018268931644 4464 6954252
SGTC_617 3770-0098 35 µM -1.43869899180615 0.10190969708949 no 3057 0.0751179125594762 4378 5962639
SGTC_547 1120-0019 610 nM -1.43905277676033 0.101855259040923 no 3058 0.0750677851064967 4431 3676939
SGTC_1979 st071809 45.3 µM -1.43974979000797 0.101748069266781 no 3059 0.0749691006078915 4502 4976333
SGTC_1660 st012960 28.1 µM -1.43979688624062 0.101740829563228 no 3060 0.0749624362017686 4486 24207266
SGTC_334 1502-1024 68.5 µM -1.44083993352276 0.101580586884306 no 3061 0.0748149544072175 4463 3296216
SGTC_2519 cryptotanshinone 88.04 µM -1.4414124688264 0.101492706824532 no 3062 0.0747340948719427 4449 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE)
SGTC_2515 chrysin 20.77 µM -1.44371555451378 0.101139759075702 no 3063 0.0744095021128041 4470 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor.
SGTC_1222 0366-0074 1.18 µM -1.44429151857852 0.101051632604887 no 3064 0.0743284952687045 4478 286520
SGTC_3199 9111318 49.47 µM -1.44646312119139 0.100719865787301 no 3065 0.0740236743087782 4378 8548020
SGTC_862 0452-0056 10.2 µM -1.4465804478033 0.100701963847773 no 3066 0.0740072327791016 4417 1575396 YLR359W | YHR072W ADE13 | ERG7
SGTC_1013 4112-3890 241 µM -1.44667728657957 0.10068718973329 no 3067 0.0739936644080949 4433 705171
SGTC_1724 st037281 8.293 µM -1.44866630897942 0.100384086074557 no 3068 0.0737153967718068 4418 574124 YDL195W SEC31
SGTC_1579 chlormadinone acetate 49.4 µM -1.44977670899678 0.100215164043862 no 3069 0.0735603982410867 4488 45114258 A steroidal progestin.
SGTC_2746 daunorubicin 9.88 µM -1.45027851236061 0.10013889421932 no 3070 0.0734904343141361 4473 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_1814 st052110 31.539 µM -1.45149835151662 0.0999536658232461 no 3071 0.0733205704691951 4400 674163
SGTC_3105 9121040 49.47 µM -1.45380989805462 0.0996033519506518 no 3072 0.0729995092601583 4427 41448907
SGTC_1771 st048882 4.1505 µM -1.4538417384831 0.0995985328197936 no 3073 0.0729950943233093 4493 4580403
SGTC_2184 6075246 200 µM -1.45916995815434 0.0987944911368239 no 3074 0.0722591675719354 4450 2267320
SGTC_1677 st019204 53.9 µM -1.46293050474381 0.0982298813158072 no 3075 0.0717431979758996 4474 3945625
SGTC_538 2922-0838 53.3 µM -1.46403132485132 0.0980650518626821 no 3076 0.0715926948184444 4498 777039
SGTC_2738 aclarubicin 5.55 µM -1.46524232529593 0.097883958938197 no 3077 0.0714274078554787 4511 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31
SGTC_1820 st053765 18.6 µM -1.4774808799038 0.0960675456733701 no 3078 0.0697733899261743 4502 3690829
SGTC_1710 st031758 61.5 µM -1.47906225220467 0.0958346626654546 no 3079 0.0695618388482103 4504 5394341
SGTC_1257 0669-0121 16 µM -1.48310102879789 0.0952417716579104 no 3080 0.0690237853648074 4475 4307855
SGTC_60 0986-0278 202 µM -1.48423984985619 0.0950750822888407 no 3081 0.0688726506798923 4442 3110598
SGTC_557 1315-0110 16.2 µM -1.48458469227963 0.0950246500723382 no 3082 0.0688269364719011 4469 6833801
SGTC_449 xestospongin c 11.1929 µM -1.4861135958111 0.0948012896571903 no 3083 0.0686245383504914 4513 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1
SGTC_3133 9127736 49.47 µM -1.4902857826843 0.0941937357478914 no 3084 0.0680745545645679 4490 27243420
SGTC_1666 st014829 29 µM -1.49070249852262 0.0941332117072141 no 3085 0.0680198099154617 4488 3858230
SGTC_3226 9131256 49.47 µM -1.49334228235587 0.093750474444146 no 3086 0.0676738064719135 4496 17178073
SGTC_1340 1486-1359 257 µM -1.49854719171883 0.0929991924007279 no 3087 0.0669955706120312 4440 4309068
SGTC_779 1360-0071 233 µM -1.49898130644225 0.0929367334788657 no 3088 0.0669392408415549 4517 7566
SGTC_2025 5147754 141 µM -1.49910904263111 0.0929183611450308 no 3089 0.0669226730529866 4471 315777 YLR208W SEC13
SGTC_2269 7935389 174.42 µM -1.4993537723269 0.0928831691011053 no 3090 0.0668909396965137 4496 97605
SGTC_3029 9088683 49.47 µM -1.5012637250407 0.0926088570817138 no 3091 0.0666436817153272 4502 25236615
SGTC_1005 4092-0690 4.4 µM -1.50434869489911 0.0921670526546497 no 3092 0.066245803534792 4515 1529343
SGTC_2 0422-0095 29 µM -1.50559679410764 0.0919887539854751 no 3093 0.0660853559831959 4412 6790840
SGTC_1941 st076221 61.8 µM -1.51107124369934 0.0912097116343572 no 3094 0.0653851501626622 4384 2828568
SGTC_2896 9052656 71.43 µM -1.51169160593958 0.0911217404277897 no 3095 0.0653061675174386 4201 6469436
SGTC_2946 9065502 71.43 µM -1.51336979503898 0.0908840781996325 no 3096 0.0650928764744691 4363 16489101
SGTC_427 1354-0053 47.3 µM -1.51657795329334 0.0904310248668123 no 3097 0.0646866375780264 4525 6813657
SGTC_2143 5623677 140.463 µM -1.51917214796236 0.090065902902838 no 3098 0.0643595850135153 4456 5375313
SGTC_1652 st011932 78 µM -1.52093116046838 0.0898189531805385 no 3099 0.0641385566633777 4443 1551076
SGTC_1296 1068-0102 11.9 µM -1.52297982458295 0.0895319737972685 no 3100 0.0638818765422797 4510 767053
SGTC_959 1222-0044 107 µM -1.52861461914511 0.0887461626269 no 3101 0.0631800048512805 4500 6083612
SGTC_682 0kpi-0099 17 µM -1.54772878028759 0.0861188166138523 no 3102 0.0608438049094505 4523 1714895 YML126C ERG13
SGTC_3042 9091578 49.47 µM -1.54812837353282 0.0860645181101963 no 3103 0.0607956960100226 4507 25236497
SGTC_3345 9148410 3.559 µM -1.55230439855817 0.0854985930663173 no 3104 0.0602947029810277 4471 4903596
SGTC_813 k007-0158 173 µM -1.55349871527329 0.0853372557082193 no 3105 0.0601520179754711 4528 6523916
SGTC_3323 9138564 53.9225 µM -1.55353479330761 0.0853323855649862 no 3106 0.0601477118500464 4544 43912313 YNL103W MET4
SGTC_2847 9005661 71.43 µM -1.55387172068282 0.085286914075694 no 3107 0.0601075092379353 4558 2991449
SGTC_809 3998-0021 90 µM -1.56384647929946 0.0839489378023494 no 3108 0.0589268129817876 4484 715485
SGTC_1924 st058459 75.1 µM -1.56837637159083 0.0833465454621553 no 3109 0.0583966610380003 4497 688683
SGTC_1469 k284-2957 126 µM -1.578323017948 0.082035233694334 no 3110 0.0572457102617467 4542 23884841
SGTC_466 geldanamycin 89.2 µM -1.57849706842587 0.0820124270067833 no 3111 0.0572257305430012 4560 5288382 HSP90 inhibitor.
SGTC_426 0988-0037 14.6 µM -1.57879888490856 0.0819728898383994 no 3112 0.0571910972337257 4540 5383008
SGTC_2415 st077333 57.7 µM -1.58098401660904 0.0816870716029719 no 3113 0.0569408461754964 4537 2766255
SGTC_1379 2144-0755 36.5 µM -1.58328216695309 0.0813872816425687 no 3114 0.0566785828343972 4576 5392327
SGTC_1272 0839-0021 27 µM -1.58375430563366 0.0813257948105445 no 3115 0.0566248207087153 4575 5027250
SGTC_1554 st069299 38.7 µM -1.58507354242659 0.0811541757628394 no 3116 0.0564748130282056 4489 24207999
SGTC_1306 1185-0270 9.02 µM -1.58949613236908 0.0805808361118627 no 3117 0.0559742132725433 4549 1548076
SGTC_1256 0570-0116 285 µM -1.59675461470154 0.0796464935245162 no 3118 0.055160208152385 4534 410638
SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM -1.5967980775074 0.0796409236003493 no 3119 0.0551553623170039 4513 279621
SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM -1.60397928897462 0.0787246652072605 no 3120 0.0543593089491798 4562 616764
SGTC_1428 4049-0204 61.7 µM -1.6047264147975 0.078629799280976 no 3121 0.0542770130667439 4583 X1428
SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM -1.60509954283956 0.0785824539868451 no 3122 0.054235949951544 4606 368090
SGTC_2752 diclazuril 33.15 µM -1.61031350201885 0.0779231262815392 no 3123 0.0536647165438832 4466 456389 An antifungal agent for coccidioides. YHR062C RPP1
SGTC_249 wiskostatin 11.211 µM -1.61313599802961 0.0775679651394977 no 3124 0.0533574822757862 4517 2775510 A n-wasp and actin depolymerizer.
SGTC_2038 4100038 30.985 µM -1.61910273852711 0.0768212039715519 no 3125 0.0527125798493395 4511 3596803
SGTC_2645 abamectin 100 µM -1.62025241618244 0.0766779474027365 no 3126 0.0525890329653759 4507 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels.
SGTC_916 4466-0038 42 nM -1.62266173052703 0.0763783918261449 no 3127 0.0523308682476141 4594 5722064 YGL116W CDC20
SGTC_702 1488-0190 94 µM -1.62413820106682 0.0761952593882823 no 3128 0.0521731582893086 4596 949357
SGTC_3027 9089541 49.47 µM -1.62449282398577 0.0761513239304327 no 3129 0.0521353353394297 4547 9943819
SGTC_73 0327-0325 16.231 µM -1.63179687675662 0.0752506827434245 no 3130 0.0513611417508836 4369 53298
SGTC_442 cape 100 µM -1.63209107049279 0.0752145774483667 no 3131 0.0513301512906369 4594 5281787
SGTC_1031 k035-0009 16 µM -1.63283445179702 0.0751234038987015 no 3132 0.0512519095494101 4595 5180959
SGTC_1196 1588-0294 184 µM -1.63462974203206 0.0749035643321626 no 3133 0.051063344433943 4593 6144269
SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM -1.63556223386624 0.074789571268554 no 3134 0.0509656199161744 4575 6710655
SGTC_2858 9025781 8.96 µM -1.63735317752955 0.0745710075093298 no 3135 0.0507783477999865 4391 4894980 YPL153C RAD53
SGTC_2879 9041815 71.43 µM -1.63828494955719 0.0744574885872217 no 3136 0.0506811328929348 4606 4942971
SGTC_1212 0520-0165 585 µM -1.64505020824655 0.0736372216153858 no 3137 0.0499797287398834 4597 5403258
SGTC_2935 9038016 29.96 µM -1.65010175239906 0.0730292559462953 no 3138 0.0494610632057175 4525 6463195
SGTC_2384 9036245 200 µM -1.65533707040667 0.0724032341133658 no 3139 0.0489280716475698 4538 6462766
SGTC_1404 3909-7820 48.3 µM -1.65865606769631 0.0720084942237039 no 3140 0.0485925583978138 4555 23741373
SGTC_1273 0849-0096 14.1 µM -1.66026723818894 0.0718174680047455 no 3141 0.0484303517095363 4586 5286025
SGTC_919 tnp00227 403.569 nM -1.66083850526535 0.0717498299210288 no 3142 0.0483729427485653 4537 1269246 A methoxyflavone. YNL221C POP1
SGTC_2335 9018011 154.17 µM -1.66229340673593 0.071577790119367 no 3143 0.0482269795728858 4551 6458208
SGTC_1270 0831-1170 17.3 µM -1.6627990456985 0.0715180732828648 no 3144 0.0481763338688546 4588 6764716
SGTC_1996 st072960 66.8 µM -1.66444897581042 0.0713234795704124 no 3145 0.0480113698384971 4600 1719405
SGTC_3343 9148379 18.9835 µM -1.66667585117847 0.0710614853826325 no 3146 0.0477894386308521 4581 1955036
SGTC_1450 4112-4260 37.6 µM -1.67071538890218 0.0705881167820058 no 3147 0.0473889538827907 4565 1633175
SGTC_2638 epoxomicin 18 µM -1.67457029122808 0.0701386480599105 no 3148 0.0470092861459922 4547 9915668 A protesome inhibitor.
SGTC_3164 9100705 49.47 µM -1.67714847680236 0.0698392709528067 no 3149 0.0467567256533327 4601 17174235
SGTC_1407 3909-7909 12.3 µM -1.68011344991252 0.0694961972650178 no 3150 0.0464676222505026 4603 4411780
SGTC_763 3453-1109 128 µM -1.68149103096181 0.0693372411514877 no 3151 0.0463337885614513 4610 1560353
SGTC_1395 3486-0190 4.35 µM -1.68161398727033 0.0693230671125862 no 3152 0.0463218582645293 4564 6748079
SGTC_183 3914-0051 30.55 µM -1.68665238635232 0.0687441728954466 no 3153 0.0458351062505808 4573 1596232
SGTC_3007 9078383 71.4286 µM -1.69566312042565 0.0677181750127832 no 3154 0.0449748482832116 4592 6496995
SGTC_2525 harmine 47.85 µM -1.6998582009384 0.0672445604701169 no 3155 0.0445788004369294 4608 5280953 A monoamine oxidase inhibitor
SGTC_2447 5741742 33.78 µM -1.70334731137363 0.0668526024268959 no 3156 0.0442515458073983 4632 1776504
SGTC_764 1951-2361 146 µM -1.70701680725134 0.0664422897571874 no 3157 0.043909464250885 4591 5438930
SGTC_2158 5657123 3.6195 µM -1.7105732786272 0.0660464783846575 no 3158 0.0435799576538756 4596 2858827
SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM -1.71153832127083 0.0659393913529175 no 3159 0.0434908916370381 4564 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM -1.71206562005346 0.0658809359258792 no 3160 0.0434422881229992 4593 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_533 1222-0222 6.71 µM -1.71232227904829 0.0658524976907371 no 3161 0.0434186465732375 4619 3982874
SGTC_1968 st069590 43.6 µM -1.71349320401181 0.0657228779920287 no 3162 0.0433109212812112 4561 6384066
SGTC_2389 9091542 195.52 µM -1.71361461224895 0.0657094496005039 no 3163 0.0432997640625995 4562 3626624 YOL127W RPL25
SGTC_2182 6325192 200 µM -1.71615039480233 0.06542946455319 no 3164 0.0430672598010077 4614 736248
SGTC_3004 9076122 71.4286 µM -1.71795333524613 0.0652309587519491 no 3165 0.0429025636333955 4586 44782551
SGTC_2697 mebhydrolin 72.4 µM -1.71948509582136 0.0650626775686372 no 3166 0.0427630396036738 4606 22530 H1 Histamine receptor antagonist. YIL048W NEO1
SGTC_712 r015-0009 80.6 µM -1.72035802173573 0.0649669276357518 no 3167 0.0426836912948585 4628 6813872 YLR060W FRS1
SGTC_2780 5215298 71.43 µM -1.72147222599505 0.0648448711945375 no 3168 0.0425825839374629 4601 2834131
SGTC_2237 6667747 47.222 µM -1.72676873594261 0.0642670938216118 no 3169 0.0421046027197517 4597 729940 YDL015C TSC13
SGTC_3151 9099821 49.47 µM -1.72682905249408 0.0642605372216826 no 3170 0.0420991845893687 4546 17174189
SGTC_1698 5-fluorocytosine 1.055 µM -1.72692889879906 0.0642496847551346 no 3171 0.0420902168105438 4605 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_3216 9129716 49.47 µM -1.7325699199424 0.0636388630229307 no 3172 0.0415860697661526 4510 8056934
SGTC_756 0508-1999 28.3 µM -1.73336531596736 0.0635531005244382 no 3173 0.04151537911918 4625 6753853
SGTC_2859 9028643 45.46 µM -1.73427609937492 0.0634550070252918 no 3174 0.0414345530518035 4450 17151580
SGTC_1499 4480-0877 67.3 µM -1.73585787074336 0.0632849266500158 no 3175 0.0412944842739485 4616 2861909
SGTC_1078 idebenone 36.1 µM -1.73976402356971 0.0628664370095511 no 3176 0.040950231035888 4620 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen.
SGTC_2647 atorvastatin 60.16 µM -1.74023274499849 0.0628163652899005 no 3177 0.0409090790197738 4597 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7
SGTC_1560 lithocholic acid 53.1 µM -1.74031481715668 0.0628076010326153 no 3178 0.0409018768388298 4557 9903 A bile acid which acts as a detergent.
SGTC_217 ketoconazole 989 nM -1.74241480413986 0.0625836732087332 no 3179 0.040717943654401 4409 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4
SGTC_2411 st077133 39.94 µM -1.74266324477241 0.0625572224696648 no 3180 0.0406962277641988 4563 1403142 YNL221C POP1
SGTC_3065 9113888 49.47 µM -1.74486886728611 0.0623227783350422 no 3181 0.0405038488538717 4614 16648368
SGTC_319 1348-1596 45.5 µM -1.75087665313756 0.0616876622286499 no 3182 0.0399835795792555 4657 5380505
SGTC_619 1652-1634 108 µM -1.75263703184177 0.0615025233893986 no 3183 0.0398321652541652 4603 5400454
SGTC_822 1487-0950 154 µM -1.75934690667984 0.0608008235830363 no 3184 0.0392593019915842 4602 1958375
SGTC_3125 9127534 49.47 µM -1.760476427551 0.0606833195508251 no 3185 0.0391635304237504 4546 1639235
SGTC_3150 9097574 49.47 µM -1.76356179653071 0.0603632538431801 no 3186 0.0389028922443668 4628 17217476
SGTC_1346 1488-2224 62.4 µM -1.77107282015296 0.0595896085293775 no 3187 0.0382742965588659 4626 3722427
SGTC_1058 3448-5425 97.3 µM -1.77107842351678 0.0595890342900292 no 3188 0.0382738307248341 4572 7279705
SGTC_2463 5473429 200 µM -1.77182965569355 0.0595120863857499 no 3189 0.0382114190989251 4621 5399405
SGTC_393 acivicin 6.25 µM -1.78008999171736 0.0586711165406575 no 3190 0.037530617116194 4493 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1
SGTC_2968 9090663 33.37 µM -1.78082660396147 0.0585965787011303 no 3191 0.0374703909286339 4554 25236811
SGTC_3111 9122088 49.47 µM -1.78296465776964 0.0583806499141829 no 3192 0.0372960283144576 4579 16876704
SGTC_1427 4048-4900 550 nM -1.78750798070994 0.0579238806458629 no 3193 0.0369277116981906 4606 24132586
SGTC_1534 6-azauridine 81.6 µM -1.79475895648145 0.0572007183014768 no 3194 0.0363460563535487 4653 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1
SGTC_2741 miltefosine 3.04 µM -1.79500096381969 0.0571767052584665 no 3195 0.0363267731875837 4664 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis.
SGTC_1516 st013856 110 µM -1.79720801767485 0.0569580775402187 no 3196 0.0361513010876234 4638 5281404 A mutagen and neurotoxin.
SGTC_2671 danthron 100 µM -1.79826147645974 0.0568539556996869 no 3197 0.036067790738148 4613 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin.
SGTC_2175 5807670 165.306 µM -1.81231674676557 0.055479055962086 no 3198 0.0349686341920075 4598 241186
SGTC_2466 5983409 37.09 µM -1.81327881176265 0.0553859141867131 no 3199 0.0348944147844294 4633 2879657
SGTC_2004 4023728 41.89 µM -1.81370265303014 0.0553449194365798 no 3200 0.0348617582104749 4579 360084 YDR527W RBA50
SGTC_3030 9087619 49.47 µM -1.81461756202687 0.0552565093506247 no 3201 0.0347913508575937 4621 25236973
SGTC_2545 solidagenone 89.61 µM -1.81948674602837 0.0547878622486042 no 3202 0.0344186015406347 4598 6708572 An anti ulcer agent
SGTC_606 k015-0008 38.6 µM -1.82530464725614 0.0542320295226779 no 3203 0.0339775346406096 4688 1970475
SGTC_551 k048-0028 34.9 µM -1.83181917409576 0.0536149479582472 no 3204 0.0334891827950541 4598 6836383
SGTC_344 k064-0035 6.43 µM -1.83694485976293 0.0531333435790047 no 3205 0.0331090179553136 4578 5088750
SGTC_1324 1418-0026 34.4 µM -1.83718984819483 0.0531104108757095 no 3206 0.0330909369088323 4651 1372513
SGTC_1235 benzylparaben 21.5 µM -1.8404069520966 0.0528099941213189 no 3207 0.0328542567852627 4678 7180
SGTC_2863 9028737 58.44 µM -1.84889146584763 0.0520241644442706 no 3208 0.0322367431246569 4646 6460917
SGTC_2536 dehydroabietamide 32.04 µM -1.85159661581957 0.0517755778316813 no 3209 0.0320418846873045 4651 3983547
SGTC_3010 9080089 71.4286 µM -1.8520346091863 0.0517354178922514 no 3210 0.032010426643331 4647 17027233
SGTC_255 tunicamycin 200.472 nM -1.8531106111577 0.0516368635964265 no 3211 0.0319332531136068 4569 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_2915 7971052 15.16 µM -1.86320472944677 0.0507195642213927 no 3212 0.0312167338722833 4611 5741558
SGTC_2861 9024595 19.48 µM -1.86471329839191 0.0505835950940739 no 3213 0.0311108008678523 4621 16482810
SGTC_572 0960-0087 17.7 µM -1.86682318779264 0.0503939154356934 no 3214 0.0309631416307673 4622 6796365
SGTC_2648 atorvastatin 78.68 µM -1.86958776006998 0.0501462379354517 no 3215 0.0307705431476264 4665 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11
SGTC_699 0375-0592 111 µM -1.88556834345884 0.0487335022585186 no 3216 0.0296765733303361 4705 762578
SGTC_2815 7968870 71.43 µM -1.88774339745653 0.0485437043398757 no 3217 0.0295302036389137 4579 2977326 YHR190W ERG9
SGTC_266 formosanin C 406 nM -1.89156660753722 0.0482115191770747 no 3218 0.0292743742680348 4506 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1
SGTC_986 1493-0483 84 µM -1.89700486006019 0.0477421447777596 no 3219 0.0289136483296664 4637 40079
SGTC_1982 st072467 71.9 µM -1.90205135835629 0.0473098627119984 no 3220 0.0285822203299394 4649 3163533
SGTC_660 4031-1742 102 µM -1.91652350735657 0.0460875581439103 no 3221 0.0276492469915404 4556 6738706
SGTC_158 k038-0087 26.446 µM -1.91904849945703 0.0458769216558354 no 3222 0.0274890981225368 4582 X158
SGTC_3012 9080433 71.4286 µM -1.92124679420279 0.0456941690219619 no 3223 0.0273503006639187 4658 17688859
SGTC_425 3825-7017 13.1 µM -1.93015753709207 0.0449593705469194 no 3224 0.02679366055584 4650 3397440
SGTC_2407 paclitaxel 400 µM -1.938124892179 0.0443104478646264 no 3225 0.0263039936111292 4661 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_2795 7780010 54.55 µM -1.93851319805377 0.0442790151758745 no 3226 0.0262803211004061 4627 953673
SGTC_53 0973-0023 39.979 µM -1.9385594223599 0.0442752745955718 no 3227 0.026277504288486 4592 674768
SGTC_1498 4478-3555 97.6 µM -1.95407160191323 0.0430343048962308 no 3228 0.0253463749832355 4687 3437919
SGTC_2518 prenyletin 46.28 µM -1.9620037141282 0.0424106827380862 no 3229 0.024881025919958 4711 3873459 A coumarin with calcium channel inhibitory activity.
SGTC_2586 curcumin 80 µM -1.96626783364632 0.042078470985951 no 3230 0.0246338401997368 4579 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40
SGTC_2157 5649910 96.377 µM -1.96910349636426 0.041858716703148 no 3231 0.0244706037204466 4659 2858091
SGTC_846 0335-0850 148 µM -1.98545817231933 0.0406093568019653 no 3232 0.0235467596789835 4674 6819598
SGTC_3128 9127691 49.47 µM -1.98700076839487 0.0404930941682239 no 3233 0.0234611558473875 4680 41316314
SGTC_3249 9135183 49.47 µM -1.98863419454494 0.0403702805527086 no 3234 0.0233707971165862 4647 4902779
SGTC_3127 9126946 49.47 µM -1.99762823556642 0.0396994466711451 no 3235 0.0228784898761775 4644 27243249
SGTC_737 1950-0117 57.9 µM -2.00051372418738 0.0394861586460792 no 3236 0.0227224097280147 4679 5393513
SGTC_1088 bifonazole 369 nM -2.00142127671842 0.0394192676745111 no 3237 0.0226735048302208 4688 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase.
SGTC_2779 methotrexate 400 µM -2.01095141073324 0.0387224032112252 no 3238 0.0221652946261572 4665 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2
SGTC_2764 methyldopa 94.69 µM -2.01470490593647 0.038450708732914 no 3239 0.0219677889350468 4654 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent.
SGTC_1828 st055811 49 µM -2.02444726011922 0.0377527591992495 no 3240 0.0214620766330432 4690 5877589
SGTC_2766 oltipraz 83.91 µM -2.02604004926175 0.0376396402146765 no 3241 0.0213803403666594 4668 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40
SGTC_293 4049-0273 38.5 µM -2.02942676719614 0.0374000370439676 no 3242 0.0212074205262395 4594 1380311
SGTC_988 1497-1057 103 µM -2.03743953185191 0.0368381090393851 no 3243 0.0208030078642144 4686 3533044
SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM -2.04202572458876 0.0365196023046582 no 3244 0.0205744898305762 4632 6708739 YPR165W RHO1
SGTC_1010 4112-3296 15.2 µM -2.04616184958937 0.0362342881137741 no 3245 0.0203702247294661 4705 704384
SGTC_1923 st058458 19.1 µM -2.05143647191896 0.0358730893720643 no 3246 0.0201122301609413 4676 3534982
SGTC_2765 myclobutanil 7.74 µM -2.05287379186893 0.0357751767838391 no 3247 0.0200424097132889 4681 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11
SGTC_1697 st025554 27.742 µM -2.06640942218458 0.0348638077633688 no 3248 0.0193949185073014 4722 1269519
SGTC_2986 9022445 71.43 µM -2.06745368007389 0.0347942959191272 no 3249 0.0193457122717016 4684 6459286
SGTC_340 k038-0059 454 µM -2.06983844036136 0.0346359790907999 no 3250 0.0192337381405776 4698 23733424
SGTC_1054 3429-0080 167 µM -2.0739348461132 0.0343654127052884 no 3251 0.0190426811315434 4691 1162877
SGTC_943 3253-1379 105 µM -2.07890460622494 0.0340394958507774 no 3252 0.0188130596350863 4671 668464
SGTC_1526 st051518 75 µM -2.09019676033019 0.0333083992344775 no 3253 0.0183000642231402 4674 673993
SGTC_2574 2',4'-dihydroxychalcone 14.64 µM -2.09542104903751 0.0329745610508615 no 3254 0.0180667899988903 4675 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_2481 5478948 45.16 µM -2.09552094645014 0.0329682044554207 no 3255 0.0180623542081168 4685 77792
SGTC_2595 hexamethylquercetagetin 100 µM -2.12770131710752 0.0309724609999074 no 3256 0.0166809278261235 4670 386331
SGTC_694 1315-0438 43.2 µM -2.12890641704018 0.0308997098713787 no 3257 0.0166310018825354 4736 6793154
SGTC_738 1315-0003 72.4 µM -2.1312343618003 0.0307595737997173 no 3258 0.0165349197460866 4711 6251474
SGTC_2399 5884133 200 µM -2.13512994098384 0.0305262474962053 no 3259 0.0163751987828783 4650 722445
SGTC_2862 9027634 71.43 µM -2.14288575730575 0.03006607585338 no 3260 0.0160611364518878 4685 5012562
SGTC_938 3126-1755 342 µM -2.14812565103635 0.0297584472709261 no 3261 0.0158518874954318 4717 1777771
SGTC_2612 dictamnine 15.46 µM -2.16214546306308 0.0289481785447195 no 3262 0.015303482841928 4636 68085 A quinoline derivative and established mutagen. YOR116C RPO31
SGTC_1333 1482-0047 286 µM -2.16986675509054 0.0285098158367166 no 3263 0.0150084707353319 4721 3811116
SGTC_670 4204-0025 119 µM -2.17392855319238 0.0282814399090218 no 3264 0.0148552506507997 4705 719039
SGTC_2375 9072683 200 µM -2.17771561094 0.0280698849635153 no 3265 0.0147136079764262 4738 16798029
SGTC_2739 tacrine 100.86 µM -2.18553926634185 0.0276370067732452 no 3266 0.0144246650791053 4743 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders.
SGTC_185 k048-0037 25.491 µM -2.19172139958949 0.0272989011097384 no 3267 0.0141998147871361 4750 6827589
SGTC_1962 st076595 64.5 µM -2.19328423917667 0.0272139766671649 no 3268 0.0141434532341433 4694 279619
SGTC_875 0709-0210 25.7 µM -2.20264764456625 0.0267097745671662 no 3269 0.0138097965248553 4719 6251364
SGTC_655 k060-0012 42 µM -2.21515295150044 0.0260485765125989 no 3270 0.0133747839806319 4735 5994525
SGTC_2983 9022671 12.99 µM -2.21583466844846 0.0260129288455197 no 3271 0.0133514135945008 4710 6405161
SGTC_2401 5128683 200 µM -2.22793788761269 0.0253868023674349 no 3272 0.0129423286094646 4698 708373
SGTC_1048 3161-0300 24.5 µM -2.22802376407438 0.0253824052937668 no 3273 0.0129394651744465 4723 2165101
SGTC_3136 9095672 49.47 µM -2.23287713714284 0.0251349361697168 no 3274 0.0127785238294274 4646 17217380
SGTC_1217 1183-1422 255 µM -2.24197342135118 0.0246765704195303 no 3275 0.012481545070263 4737 2849664
SGTC_718 1130-0073 349 µM -2.24599629462587 0.0244761040544774 no 3276 0.0123521226231482 4734 6740020
SGTC_2736 butenafine 14.65 µM -2.26181697388917 0.0237009437833612 no 3277 0.0118543568475746 4692 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_562 3772-2733 112 µM -2.26545585790825 0.0235256007909713 no 3278 0.0117423599516542 4702 2876874 YIL048W NEO1
SGTC_2396 5342950 42.78 µM -2.26949269411398 0.0233323601582583 no 3279 0.0116191905041367 4705 1886677
SGTC_1073 triclabendazole 3.09 µM -2.27757001260045 0.0229497132111839 no 3280 0.0113761044243441 4752 50248 An antihelmetic and likely tubulin inhibitor.
SGTC_3317 9138495 8.753 µM -2.27787435611819 0.0229353994933152 no 3281 0.0113670322735896 4690 17020139
SGTC_546 peri-Naphthalide 147 µM -2.2823270312613 0.0227268421221032 no 3282 0.0112350198945142 4723 223824 A penicillin ester.
SGTC_1514 1189-1591 158 µM -2.28986789302542 0.0223772840595698 no 3283 0.0110144879794774 4729 767698 YMR146C TIF34
SGTC_268 camptothecin 39.6153 µM -2.29468065253977 0.0221565670114727 no 3284 0.0108757161868545 4695 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_3064 1327-0027 10 µM -2.29815975922748 0.0219981589031672 no 3285 0.0107763490362723 4727 16000455 YPR107C YTH1
SGTC_749 1000-0129 128 µM -2.30995792195423 0.0214680746258074 no 3286 0.0104452419048109 4750 708470
SGTC_2096 5468907 200 µM -2.31364818654048 0.0213045063415534 no 3287 0.0103435140976444 4754 759785
SGTC_934 2950-0684 338 µM -2.32342711709281 0.0208761512511394 no 3288 0.0100781093829252 4739 1121253
SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM -2.33083933876226 0.0205563448929801 no 3289 0.00988091646302305 4715 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W
SGTC_2021 4019055 173 µM -2.34831249838712 0.019818840141495 no 3290 0.00942934579323943 4572 44827708 YER133W GLC7
SGTC_2776 terbinafine 19.92 µM -2.35872797751236 0.0193900005070497 no 3291 0.00916884612585792 4731 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_884 0851-0618 334 µM -2.37006268053605 0.0189322972181233 no 3292 0.00889253492604063 4761 9642473
SGTC_1731 st035964 63 µM -2.37132542693475 0.018881880232711 no 3293 0.00886220875910881 4659 6739575
SGTC_1798 st045719 60.953 µM -2.37703863972677 0.0186551969918865 no 3294 0.0087261299203931 4727 3980186
SGTC_3219 9131112 49.47 µM -2.37866774494183 0.0185909849624804 no 3295 0.0086876646689208 4626 17612988 YMR079W SEC14
SGTC_1326 1431-2094 10.8 µM -2.38030830959763 0.0185265115046551 no 3296 0.00864907918592579 4754 616278
SGTC_2275 7947463 200 µM -2.39037297125231 0.0181351274861527 no 3297 0.00841563523784987 4726 1225414
SGTC_662 k832-1615 104 µM -2.39153051651814 0.0180905692467413 no 3298 0.00838914454386123 4757 5878478
SGTC_2910 7948405 25.97 µM -2.4026096878301 0.0176687918162217 no 3299 0.00813927589669435 4748 2971328
SGTC_1072 oxiconazole 14.9 nM -2.46476891736761 0.0154548756129494 no 3300 0.00685508200016493 4729 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_2432 5630864 12.22 µM -2.46935812037989 0.0153013051412269 no 3301 0.00676778410261562 4752 5714970
SGTC_3287 9117173 37.0625 µM -2.46976065956376 0.0152878975345451 no 3302 0.00676017388205638 4769 2789709
SGTC_2685 mycophenolic acid 18.85 µM -2.47322541662772 0.01517291146601 no 3303 0.00669498278567913 4775 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_360 0957-0399 1.01 µM -2.49083430715998 0.0145999359739257 no 3304 0.0063721768848817 4753 6752301 YPR165W RHO1
SGTC_2115 tiliquinol 12.7705 µM -2.49338875125552 0.0145183831964281 no 3305 0.00632651139579991 4744 71208 A bioactive hydroxyquinoline.
SGTC_2695 st077686 51.995 µM -2.49895557588582 0.0143420149572611 no 3306 0.00622799622328659 4731 2876092
SGTC_2941 9056145 11.23 µM -2.53209603275379 0.0133297868679981 no 3307 0.00566914667337036 4747 2119517
SGTC_431 k089-0097 107 µM -2.54334093600468 0.0130006419128226 no 3308 0.00548990180770204 4515 5499420
SGTC_3139 9095020 49.47 µM -2.56498881184932 0.0123867409385629 no 3309 0.00515895659745458 4725 25236292
SGTC_3314 9135860 59.4275 µM -2.57144264375678 0.0122086482064977 no 3310 0.0050637894784591 4754 25252478
SGTC_1773 st048542 73.5835 µM -2.59965533658948 0.0114559316260069 no 3311 0.00466587167438165 4762 3237138
SGTC_1507 4075-3230 155 µM -2.6258369250808 0.0107938047448583 no 3312 0.00432181086673101 4749 659771
SGTC_1377 2944-0135 198 µM -2.63060198978749 0.0106769493280522 no 3313 0.00426168953636661 4758 1894137
SGTC_1079 idarubicin 2.36 µM -2.64558646559442 0.0103166299904618 no 3314 0.00407747212539263 4789 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_122 0236-0016 402.397 µM -2.66065203859898 0.00996509529209468 no 3315 0.00389947539510744 4765 6808838
SGTC_367 0335-0881 7.1 µM -2.68301301357361 0.00946261755519882 no 3316 0.00364810755647446 4726 23828853
SGTC_3142 9086498 49.47 µM -2.68466221378659 0.00942645112328109 no 3317 0.00363015709665235 4697 25236367
SGTC_3297 9117502 71.43 µM -2.68554139316956 0.00940722044857162 no 3318 0.00362062023206036 4771 7453720
SGTC_2435 5706476 10.6 µM -2.68833252342057 0.00934639604580661 no 3319 0.00359049237349531 4770 5725375
SGTC_1200 1643-0193 18.4 µM -2.69174129827589 0.00927257880607502 no 3320 0.00355400291461694 4784 5403974
SGTC_2012 4023501 200 µM -2.69217130175559 0.00926330338582955 no 3321 0.00354942364068555 4756 3477460
SGTC_2778 tioconazole 65.09 nM -2.72305028927529 0.00861809872801735 no 3322 0.00323411055061525 4701 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_1707 st032323 6.317 µM -2.76365580686813 0.00782985270975692 no 3323 0.00285788983201294 4654 3132057 YMR211W DML1
SGTC_1051 3253-3903 78 µM -2.79394677832555 0.0072838514658368 no 3324 0.00260345236849799 4778 5509239
SGTC_2377 9073351 62.6 µM -2.81027621944181 0.00700366680484845 no 3325 0.00247494989844667 4774 7337946 YHR072W ERG7
SGTC_3063 1327-0034 4 µM -2.83641512542873 0.00657494651366651 no 3326 0.00228115513972689 4717 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_3071 9117417 49.47 µM -2.92485922258301 0.00529137923166676 no 3327 0.00172306041126649 4767 45595590 YGL055W OLE1
SGTC_2541 muurolladie-3-one 83.07 µM -2.94685834334418 0.00500895575653324 no 3328 0.00160510113241437 4777 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils. YMR203W TOM40
SGTC_339 3091-4833 71.4 µM -3.00342264778603 0.00434346602990861 no 3329 0.00133480701445704 4693 3240077
SGTC_1194 1488-0194 225 µM -3.01405406359132 0.00422759982236184 no 3330 0.00128890932419182 4798 1391452
SGTC_3059 1327-0034 3 µM -3.03126768494942 0.00404585019033922 no 3331 0.00121764621248578 4739 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_1917 st066507 28.5 µM -3.04464564727864 0.00390946384825686 no 3332 0.00116477301702889 4714 3156428
SGTC_410 α-linolenic acid 100 µM -3.05400524298458 0.00381650825223074 no 3333 0.00112904067221313 4794 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_1739 st037196 92.5 µM -3.05599335009774 0.00379702019170265 no 3334 0.00112158115456387 4784 612214
SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM -3.08877096768941 0.00348833130165227 no 3335 0.00100493158336366 4797 4000243
SGTC_3329 9141233 27.5565 µM -3.19218687042487 0.00265660486568902 no 3336 0.000705999746323548 4789 4909101 YNL103W MET4
SGTC_1086 cerivastatin 2.18 µM -3.20800602535674 0.00254653781089229 no 3337 0.000668293491204411 4800 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7
SGTC_687 k029-0044 34.9 µM -3.20898853177067 0.00253983962343135 no 3338 0.000666014024944003 4798 5829338
SGTC_2567 aureobasidin a 60 nM -3.23899753884912 0.00234277357800308 no 3339 0.000599753042598171 4786 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1
SGTC_1511 0906-3109 28.5 µM -3.24789755027007 0.00228704969303398 no 3340 0.000581305618634503 4796 2882180
SGTC_374 0880-0231 82.3 µM -3.26633695441552 0.00217540146603916 no 3341 0.000544742634147249 4752 6833587
SGTC_608 k048-0125 159 µM -3.43497600467376 0.00136145550557707 no 3342 0.00029630314961718 4803 6817652 YLR060W | YFL022C FRS1 | FRS2
SGTC_2046 4110841 106 µM -3.46294423705485 0.00125724138459184 no 3343 0.000267149556638665 4802 44119630 YMR134W ERG29
SGTC_2777 climbazole 1.536 µM -3.46343875368467 0.00125546623094848 no 3344 0.000266658995473405 4710 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2
SGTC_1047 2043-3044 82 µM -3.49859267049571 0.00113499528004678 no 3345 0.000233860260431323 4788 669592
SGTC_2914 7968218 45.32 µM -3.53509134917872 0.00102120182919026 no 3346 0.000203817106053997 4802 2977111
SGTC_151 3013-0144 2.285 µM -3.79083164627498 0.000474550589797625 yes 3347 7.5071851656487e-05 4727 906558 YHR107C CDC12
SGTC_1522 st012842 45.6 µM -3.84180370834598 0.000405104425644517 yes 3348 6.10667466150716e-05 4781 3491067 YOR116C RPO31
SGTC_1718 roemerine 11.9335 µM -4.06078823646525 0.000201057688708499 yes 3349 2.44536583406572e-05 4683 235224 An aporphine alkaloid with mutagenic activity.
SGTC_893 0958-0369 48.9 µM -4.22818680340046 0.000115035181248912 yes 3350 1.17791081640544e-05 4765 6819948
SGTC_1787 fluconazole 80 µM -5.17711308570366 3.33047875349908e-06 yes 3351 1.12672818412718e-07 4741 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C