SGTCid condition conc unit KAP114|YGL241W.score KAP114|YGL241W.strain.pval KAP114|YGL241W.strain.significant KAP114|YGL241W.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene SGTC_3285 9112818 20.8695 µM 5.29247644135182 7.00470961683888e-08 yes 1 6.03355094037801e-08 13 17017947 YPR165W RHO1 SGTC_953 1188-0045 9.7 µM 4.9627542639898 3.93491759184282e-07 yes 2 3.47502462296019e-07 9 6144426 SGTC_3288 9119690 36.221 µM 4.68975446729418 1.51933149864013e-06 yes 3 1.36766537004302e-06 16 17595618 YKL019W RAM2 SGTC_1655 st012546 55.1 µM 4.49464989206317 3.82132626688304e-06 yes 4 3.484225165046e-06 18 720985 YLR208W SEC13 SGTC_3143 9086658 49.47 µM 4.28638422660701 9.83116302385892e-06 yes 5 9.08023886130467e-06 35 25236626 SGTC_474 dl-dihydrosphingosine 5 µM 4.2770299037112 1.02475963030995e-05 yes 6 9.47016841907997e-06 20 3058739 A sphingolipid protein kinase C inhibitor. SGTC_3294 9122953 26.2835 µM 4.2362507040704 1.22672943659434e-05 yes 7 1.13641501064491e-05 20 16459826 SGTC_3067 9117431 49.47 µM 4.08883083920109 2.32022894558912e-05 yes 8 2.16776433202727e-05 7 17150885 SGTC_675 1309-0189 238 µM 4.0437785084481 2.80771352292319e-05 yes 9 2.62983050884882e-05 12 4246530 SGTC_3074 9116018 49.47 µM 3.99968117210356 3.37769505887683e-05 yes 10 3.1713937861341e-05 20 17027303 SGTC_2273 7815444 169.05 µM 3.76644381759129 8.71069896091181e-05 yes 11 8.27946625236593e-05 29 2824616 SGTC_3140 9094243 49.47 µM 3.62208491312922 0.000152645092948808 yes 12 0.000146119077611763 35 19291112 SGTC_1472 k841-0093 193 µM 3.56221881717776 0.000191537095841333 yes 13 0.000183866839193087 28 X1472 SGTC_2153 5569715 200 µM 3.53863242120949 0.000209262836751585 yes 14 0.00020110274584157 22 2054701 SGTC_2858 9025781 8.96 µM 3.46173427349186 0.000278267170853488 yes 15 0.000268353390204123 127 4894980 YPL153C RAD53 SGTC_805 3852-0218 479 µM 3.45907330775874 0.000280997448376395 yes 16 0.000271018677622069 90 6615355 SGTC_3300 9124615 50.48 µM 3.44424158444967 0.000296678139604948 yes 17 0.000286331883249099 35 24824903 SGTC_2597 laccaic acid a 100 µM 3.39750571407438 0.000351577449200145 yes 18 0.000340015838866818 54 5491415 A textile dye. SGTC_2480 5767542 37.17 µM 3.21643360003338 0.000665959073062189 yes 19 0.000648972825435713 33 2867358 SGTC_1460 k062-0059 9.15 µM 3.20700722326 0.000687909891376355 yes 20 0.00067061814038606 39 1373085 SGTC_3066 9117245 49.47 µM 3.18521252801853 0.000741241295962035 yes 21 0.00072323868126511 36 17176980 SGTC_2612 dictamnine 15.46 µM 3.1553128656903 0.000820614568832113 yes 22 0.000801630395838007 78 68085 A quinoline derivative and established mutagen. YOR116C RPO31 SGTC_1784 st039334 36.3 µM 3.10219800603181 0.000981170818590159 yes 23 0.000960447138783704 53 3496984 SGTC_3249 9135183 49.47 µM 3.086067015871 0.00103536022895474 no 24 0.00101411551750929 47 4902779 SGTC_2722 naftopidil 47.16 µM 3.03926901095499 0.00120847938686977 no 25 0.00118576493386522 33 4418 An a1-adrenergic receptor antagonist or alpha blocker.  SGTC_1433 4060-0023 7.6 µM 2.98665510165643 0.0014344828535287 no 26 0.00141023862466315 51 3840627 SGTC_423 5-fluorouracil 457 µM 2.95489798262286 0.00158893433215293 no 27 0.00156386228322361 70 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_2591 skatole 100 µM 2.95373106611934 0.00159488811652708 no 28 0.00156978736703654 75 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite. SGTC_618 k072-0232 33.2 µM 2.94276030112348 0.00165186485657486 no 29 0.00162650090926707 47 5872756 YGL099W LSG1 SGTC_2718 lomofungin 53.02 µM 2.93522900401455 0.00169204538184699 no 30 0.00166650802365862 50 5351222 A RNA synthesis inhibitor. SGTC_264 promethazine 12.5 mM 2.93339065327705 0.0017019874099607 no 31 0.0016764086652624 126 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3 SGTC_3145 9085516 49.47 µM 2.93320407826495 0.00170299939763041 no 32 0.00167741647371832 83 25236195 SGTC_2109 5483026 200 µM 2.88802487115453 0.0019648136135018 no 33 0.00193834608982696 86 759335 SGTC_2426 5582046 32.21 µM 2.84703387857873 0.00223344019686239 no 34 0.00220643329233873 80 2251934 SGTC_540 1187-0821 17.3 µM 2.81035322013777 0.00250157945000277 no 35 0.00247435778586082 64 847520 SGTC_2279 7948423 32.93 µM 2.78960725944905 0.00266581085761464 no 36 0.00263860066308992 59 1247112 SGTC_2334 9017922 200 µM 2.74378927737135 0.00306350731503779 no 37 0.00303672552346836 84 3163164 SGTC_746 1095-0025 46.6 µM 2.74202830315831 0.00307980701680001 no 38 0.00305305399753207 72 6749286 SGTC_210 3551-0445 56.827 µM 2.71637861058967 0.00332623845116331 no 39 0.00330001966710869 123 2865180 YOR207C RET1 SGTC_784 4579-0127 173 µM 2.69862732507043 0.00350701921907481 no 40 0.00348130489520905 93 1948547 SGTC_1390 3413-2614 145 µM 2.68739039727712 0.00362597003915255 no 41 0.0036006365648145 102 3421432 SGTC_3075 9116269 49.47 µM 2.68639759844825 0.00363665163149819 no 42 0.003611354195345 76 17015205 YNL244C SUI1 SGTC_2039 Aminomethylbenzodioxan 200 µM 2.6695247511985 0.00382255695495506 no 43 0.00379793372529079 55 15053 SGTC_703 3875-0075 71.8 µM 2.66844863426016 0.00383469764596296 no 44 0.00381012147338841 44 2850814 SGTC_2159 5658611 73.75 µM 2.66628016587979 0.00385926722603617 no 45 0.00383478739564539 48 793844 SGTC_3087 9117406 49.47 µM 2.66544540912775 0.00386876288434409 no 46 0.00384432068494948 79 42546093 SGTC_788 1182-0090 188 µM 2.65455830892861 0.00399453889102486 no 47 0.00397061568320221 194 5715185 SGTC_3289 9119912 71.43 µM 2.58174198016715 0.0049340997899636 no 48 0.00491515246770548 99 17014829 SGTC_204 PMA1.184 62.41 µM 2.55253596212153 0.00536319871517854 no 49 0.00534709344345153 123 2252213 YGL008C PMA1 SGTC_2261 9010538 184.68 µM 2.55093720075459 0.00538761801544412 no 50 0.00537168410418815 90 6457250 SGTC_1679 SEC14.276 6.7 µM 2.53148725762944 0.00569270743193807 no 51 0.00567899721093289 170 1005053 YMR079W SEC14 SGTC_3255 9139072 49.47 µM 2.53063799564923 0.00570637155665196 no 52 0.00569276442995315 98 17646060 SGTC_3191 9110352 49.47 µM 2.50268935305923 0.00617260247335903 no 53 0.00616268370862307 90 17122424 SGTC_1611 st001856 99.4 µM 2.49752737148198 0.00626231287491238 no 54 0.0062531404911956 103 647478 SGTC_2332 7982454 138.89 µM 2.48055094362493 0.00656554236105826 no 55 0.00655897586166843 181 2981748 SGTC_1435 4092-0789 56.7 µM 2.46069276031958 0.00693666342295565 no 56 0.00693345294871937 97 2248285 SGTC_431 k089-0097 107 µM 2.4601545969745 0.00694697365817662 no 57 0.00694385893576554 182 5499420 SGTC_682 0kpi-0099 17 µM 2.44695678234003 0.00720409005391346 no 58 0.00720340564269961 183 1714895 YML126C ERG13 SGTC_2956 9076196 2.52 µM 2.44114644130698 0.00731992168995704 no 59 0.00732035825945584 124 16423868 SGTC_2622 2-methoxyxanthone 59.94 µM 2.4284584780203 0.00757858420180961 no 60 0.00758158063680284 117 71034 A hepatoprotective. SGTC_3178 9107506 49.47 µM 2.42399713447258 0.00767142941288371 no 61 0.00767536330631446 114 8897194 SGTC_2074 5212007 75.395 µM 2.40770945125344 0.00801894850503406 no 62 0.00802647550580419 100 758611 SGTC_2857 9024691 58.44 µM 2.39576695241235 0.0082824786445973 no 63 0.00829281592343598 134 16478292 SGTC_2245 6637752 200 µM 2.37659900314243 0.00872136261415728 no 64 0.00873653585303903 86 681890 SGTC_408 cantharidin 100 µM 2.37271966028224 0.00881262769888163 no 65 0.0088288301136055 149 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_958 1222-0007 33 µM 2.36684605727455 0.00895240280380068 no 66 0.00897019667284151 161 7312461 SGTC_2544 sphondin 68.51 µM 2.36251022164404 0.00905682576640876 no 67 0.00907582043286777 136 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31 SGTC_2095 5432005 200 µM 2.35085220151624 0.00934290094465061 no 68 0.00936523603756287 108 783734 SGTC_2053 5265679 138 µM 2.34250582505625 0.00955253851065264 no 69 0.00957736748538855 175 764595 SGTC_2592 piperlongumine 83.33 µM 2.34147663545971 0.0095786715493767 no 70 0.00960381407401311 153 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_3305 9127027 53.8275 µM 2.34042372081508 0.00960547166099324 no 71 0.00963093634654813 134 41905295 SGTC_452 diindolylmethane 8 µM 2.3118253452901 0.0103588900866898 no 72 0.0103936550498769 107 3071 Inhibits expression of several cancer promoting factors. SGTC_1015 4130-4525 82 µM 2.2987445588309 0.0107203381077537 no 73 0.0107597243353884 151 1363237 SGTC_2780 5215298 71.43 µM 2.29089734707977 0.010942401646095 no 74 0.0109846757326175 184 2834131 SGTC_3227 9130768 49.47 µM 2.28630504881112 0.0110742041737193 no 75 0.0111182093629566 86 17720899 SGTC_2958 9077254 16.72 µM 2.28568417434691 0.0110921292904735 no 76 0.0111363708773799 165 16457351 SGTC_1892 st058411 7.36 µM 2.26737209908519 0.011632281025894 no 77 0.0116837522119588 174 3934738 SGTC_2855 9016525 58.44 µM 2.26251486800248 0.0117793316151571 no 78 0.0118328056450945 157 43811474 SGTC_870 0573-2213 57.6 µM 2.23904869909479 0.0125127004681457 no 79 0.0125763738355126 131 3916321 SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM 2.23747541526621 0.0125632532251158 no 80 0.0126276421898114 216 91467 include heat shock SGTC_601 0986-0029 62.9 µM 2.23611280757501 0.0126071793187002 no 81 0.0126721913539261 202 24747981 SGTC_226 1,3-diallylurea 8.28947 mM 2.23589652488191 0.0126141637886539 no 82 0.0126792750042495 131 74537 YKL182W FAS1 SGTC_1091 telmisartan 47.6 µM 2.23560253042015 0.0126236631940946 no 83 0.0126889093503802 143 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension. SGTC_1555 citronellol 128 µM 2.22322167959601 0.0130293677287481 no 84 0.0131004278298925 89 8842 A terpine precursor. SGTC_980 1473-0395 201 µM 2.20318785642934 0.0137097300154033 no 85 0.0137907554285343 112 768876 SGTC_1184 1269-1718 139 µM 2.1875876077155 0.0142605465409749 no 86 0.0143498276645626 154 5403821 SGTC_1253 0550-0034 176 µM 2.18234649759652 0.0144498295910914 no 87 0.0145419848834763 163 5969915 SGTC_476 mead acid 10 µM 2.18035155833345 0.0145224431739186 no 88 0.0146157059930139 94 5312531 An omega 9 fatty acid. SGTC_1387 3342-1166 1.8 µM 2.17817579759032 0.0146019963074066 no 89 0.0146964756018574 108 3418228 SGTC_829 1635-0120 117 µM 2.17149314902211 0.014848685328024 no 90 0.0149469572342889 204 285054 SGTC_1971 st069429 63.5 µM 2.16803855311474 0.0149776105451377 no 91 0.0150778766722872 137 1246522 YGL099W LSG1 SGTC_302 1094-0063 18.9 µM 2.16793594900004 0.0149814543900697 no 92 0.0150817801002983 128 5440289 SGTC_769 0302-0231 76 µM 2.16299509022806 0.0151675594441813 no 93 0.0152707786226171 251 571869 YER009W NTF2 SGTC_492 tmb-8 126 µM 2.15765743664501 0.0153708388829856 no 94 0.0154772377513774 65 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1 SGTC_2158 5657123 3.6195 µM 2.14921026548242 0.0156973211261473 no 95 0.0158088679524571 128 2858827 SGTC_992 3909-8734 162 µM 2.13847490246382 0.0161208114865481 no 96 0.0162391094824191 168 4288319 SGTC_1790 st045711 43.5 µM 2.13792567585316 0.0161427382271241 no 97 0.0162613879893654 168 585119 SGTC_1343 1487-0095 224 µM 2.13576477289004 0.0162292560556754 no 98 0.0163492959052296 137 4560101 YGL055W OLE1 SGTC_705 1124-0212 310 µM 2.13517704413618 0.0162528560281111 no 99 0.0163732756392063 175 9554485 SGTC_2966 9084041 48.03 µM 2.12277739061064 0.0167576540214852 no 100 0.016886255153246 202 17741380 SGTC_258 haloperidol 50.781 µM 2.12017227956818 0.0168653979832846 no 101 0.0169957596153988 233 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_736 0958-0254 92.6 µM 2.10465375433638 0.0175195746404062 no 102 0.0176607293956074 222 6812352 SGTC_2925 9010536 32.5 µM 2.10422242009925 0.0175380625186629 no 103 0.0176795248479453 270 2994177 SGTC_633 0437-0093 97.7 µM 2.10158756613865 0.0176513597927092 no 104 0.0177947099927051 158 2831118 SGTC_1833 st055984 71 µM 2.09893481702026 0.017766056955365 no 105 0.0179113235705208 174 676288 SGTC_1300 1094-0077 113 µM 2.0844818995346 0.0184021887647864 no 106 0.0185581774917228 177 5532636 SGTC_2874 9043904 71.43 µM 2.06808011478357 0.0191474999736654 no 107 0.0193162451211049 142 4463428 SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM 2.05849688067875 0.0195947341019353 no 108 0.019771230198432 145 616764 SGTC_2715 st079500 56.4 µM 2.0415131909658 0.020409134539169 no 109 0.0205999220425061 176 28246688 SGTC_2457 5731572 11.68 µM 2.03873002486862 0.0205452912609012 no 110 0.0207384897186002 152 2865357 SGTC_816 0325-0417 81.3 µM 2.02683954241464 0.0211356904772531 no 111 0.0213394125316374 187 68101 SGTC_7 0192-1582 4.227 µM 2.0266062822184 0.0211474146361293 no 112 0.0213513467903174 299 252616 SGTC_944 3370-0224 231 µM 2.02405317912538 0.0212760991392524 no 113 0.0214823401782151 214 4580514 SGTC_3266 9136860 49.47 µM 2.01915680268069 0.0215247453942949 no 114 0.0217354622552362 234 4871271 YPR165W RHO1 SGTC_1397 3532-0190 20.1 µM 2.01804606449428 0.0215814910482208 no 115 0.0217932320384424 144 5322280 SGTC_3196 9111891 49.47 µM 2.01580692012335 0.021696269355461 no 116 0.0219100848316185 174 18891510 SGTC_2675 theaflavin digallate 100 µM 2.01243062442358 0.0218703127685392 no 117 0.0220872814837624 216 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative. SGTC_1292 0kpi-0043 232 µM 1.99905437305838 0.0225714726079432 no 118 0.0228012355628277 199 3333905 SGTC_460 trequinsin 123 µM 1.99804220200037 0.0226252915921669 no 119 0.0228560425029791 149 5537 A vasodilator. SGTC_2818 7996756 12.99 µM 1.99362458152829 0.0228614525926716 no 120 0.0230965484709795 147 2241621 SGTC_3171 9103192 49.47 µM 1.97961550269699 0.0236241405083104 no 121 0.0238733748325527 159 13018434 SGTC_219 mitoxanthrone 164.414 µM 1.9789223756863 0.0236624250671738 no 122 0.0239123732870623 245 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA.  YMR168C CEP3 SGTC_1244 0416-0015 52.5 µM 1.97177429934185 0.0240602981950959 no 123 0.024317688745851 245 96201 SGTC_3084 9116877 49.47 µM 1.95728929890325 0.0248838069703053 no 124 0.0251567324614942 153 27241325 SGTC_1133 3473-0247 50 µM 1.95516241868609 0.0250066929869337 no 125 0.0252819513974043 283 711311 SGTC_559 1550-0661 158 µM 1.95347386069074 0.0251046157345779 no 126 0.0253817358407315 210 5830875 SGTC_1501 4491-0275 38.4 µM 1.95202188992104 0.0251890751473867 no 127 0.0254678028909153 201 5104718 SGTC_1493 4348-0038 111 µM 1.94874566372723 0.0253805244379531 no 128 0.0256629027978686 267 800424 SGTC_571 k831-0106 44.2 µM 1.94679419056188 0.025495138727734 no 129 0.0257797068661901 216 4783639 SGTC_2974 9094440 9.66 µM 1.93726177129641 0.0260612461828699 no 130 0.0263566763877174 282 25236134 SGTC_248 streptozotocin 5.23457 mM 1.92746396750629 0.0266540325312976 no 131 0.0269609171970598 253 5300 DNA alkylating agent. SGTC_605 1315-0399 119 µM 1.92409035138912 0.0268607320200291 no 132 0.0271716296448247 272 24020461 SGTC_2992 9074591 71.4286 µM 1.91465199785146 0.0274461349531999 no 133 0.0277684495530545 202 17741321 SGTC_3104 9120930 49.47 µM 1.91324520506054 0.0275342939806688 no 134 0.027858334441825 205 17014836 SGTC_1238 0333-0287 48.8 µM 1.91251165734651 0.0275803565390669 no 135 0.0279052994221915 240 7226 SGTC_1451 4152-0210 104 µM 1.91148895231536 0.0276446836972942 no 136 0.027970887594989 276 659563 SGTC_2278 7948257 134.34 µM 1.90918686402898 0.0277899404607864 no 137 0.0281189951200573 236 1247028 SGTC_407 eburnamonine 100 µM 1.89073566336676 0.0289772963010008 no 138 0.0293298196175051 216 3195 SGTC_2218 6965428 192.983 µM 1.88636035945577 0.0292649529989831 no 139 0.0296232052748074 214 675684 SGTC_3348 9149464 3.537 µM 1.8855281920216 0.0293199318554331 no 140 0.029679280959943 248 1951442 SGTC_2794 7785382 27.27 µM 1.88505706870381 0.0293510955962327 no 141 0.0297110666827404 335 2205081 SGTC_2100 5377183 190 µM 1.8842844844832 0.0294022598275742 no 142 0.0297632524911541 257 2844202 SGTC_3173 9105693 49.47 µM 1.87906818328141 0.0297496495112346 no 143 0.0301175919164348 277 17096658 SGTC_2657 nystatin 74.44 µM 1.87652845638553 0.0299200162525176 no 144 0.0302913754932541 247 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_763 3453-1109 128 µM 1.87472096636269 0.0300417562338802 no 145 0.0304155604715822 267 1560353 SGTC_3146 9095609 49.47 µM 1.87043522863675 0.0303320559564194 no 146 0.0307117018589876 243 17173999 SGTC_818 4072-2707 53.5 µM 1.86621810047588 0.0306199735852901 no 147 0.0310054288383901 223 882871 SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM 1.86373803838842 0.0307903502189555 no 148 0.0311792504193361 237 688798 SGTC_1503 4585-0012 61.3 µM 1.85821798969957 0.0311723880274815 no 149 0.0315690321702611 236 2922052 SGTC_455 paf C-16 10 µM 1.85547761750876 0.0313634984245853 no 150 0.0317640262847668 241 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis. SGTC_539 4859-0462 2.54 µM 1.85266896037839 0.0315603752170476 no 151 0.0319649107908216 254 46499474 YNL221C | YBR257W POP1 | POP4 SGTC_3311 9131146 2.8755 µM 1.84918780646874 0.0318058081083436 no 152 0.0322153494088005 348 4900406 YPR165W RHO1 SGTC_549 1661-1316 519 µM 1.84577130011506 0.0320482141130068 no 153 0.0324627097301374 272 2857282 SGTC_3134 9127454 49.47 µM 1.84337249563195 0.0322193226393329 no 154 0.0326373215014345 220 24262820 SGTC_2431 5490079 200 µM 1.83941762111262 0.0325030728090713 no 155 0.0329268921480379 275 5722345 SGTC_1090 efavirenz 20.7 µM 1.83130447726342 0.0330916197180254 no 156 0.0335275548778395 264 64139 A non-nucleoside reverse transcriptase inhibitor. SGTC_480 am 92016 50 µM 1.82404609563557 0.0336255754425142 no 157 0.0340725518803633 215 2129 K+ channel blocker. SGTC_153 4077-0274 519.67 µM 1.8195945168399 0.0339565453304539 no 158 0.0344103886555733 244 3121976 SGTC_2251 lansoprazole 556 µM 1.81793950923807 0.0340802745134411 no 159 0.0345366893954444 215 3883 Gastric proton pump inhibitor. YBR192W RIM2 SGTC_526 4469-0568 170 µM 1.80375388894657 0.0351560749041715 no 160 0.0356349487139509 297 2901964 SGTC_76 0433-0009 400.328 µM 1.79212133083025 0.036058910737067 no 161 0.0365567663474881 219 2841569 SGTC_440 fluspirilene 35.1 µM 1.78915679311181 0.0362920083474495 no 162 0.0367947839273849 301 3396 An atypical antipsychotic. SGTC_3243 9134147 49.47 µM 1.78892459542062 0.0363103177097201 no 163 0.036813480071301 209 24282180 SGTC_3301 9125354 19.7965 µM 1.78411250425798 0.0366914680867793 no 164 0.0372026929105919 239 41905162 SGTC_1116 jasmonic acid  1.58368 µM 1.78014834476417 0.0370079093310331 no 165 0.0375258432289255 288 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid. SGTC_2661 dactinomycin 12.96 µM 1.77894764186651 0.0371041951061762 no 166 0.0376241731611018 304 45006140 An Actinomycin D Classic transcription inhibitor. SGTC_1156 4092-0367 4.88 µM 1.77587856022629 0.0373512391063072 no 167 0.0378764677237218 322 1357585 SGTC_1916 st067606 49.2 µM 1.77332355161097 0.0375579265106181 no 168 0.038087554322944 356 19590279 SGTC_286 k060-0067 22.9 µM 1.77089509321323 0.0377552413668721 no 169 0.0382890742355236 294 5985051 SGTC_3207 9114163 49.47 µM 1.77057111283224 0.0377816289741756 no 170 0.0383160245934 357 849233 SGTC_587 k089-0003 57 µM 1.76178811312707 0.0385027421577832 no 171 0.0390525519259502 171 9659696 SGTC_3233 9132340 49.47 µM 1.7580195808031 0.0388155712519225 no 172 0.0393720888493095 281 17682950 SGTC_277 nystatin 15.5 µM 1.75593362075111 0.0389896167555944 no 173 0.0395498717136094 312 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_1903 st060211 78.3 µM 1.7536435568173 0.0391814231877849 no 174 0.0397458013193518 335 688960 SGTC_317 4495-0002 170 µM 1.74862386303621 0.0396045394284859 no 175 0.0401780293131181 267 15991618 SGTC_1636 st007707 68.9 µM 1.74725233283894 0.0397207915522721 no 176 0.0402967887797341 347 403051 SGTC_3279 9140807 49.47 µM 1.74282854960257 0.0400976472569392 no 177 0.0406817838803346 272 45595718 SGTC_1212 0520-0165 585 µM 1.73756446389584 0.0405498667270079 no 178 0.0411437929961816 320 5403258 SGTC_940 3232-1287 54.8 µM 1.73524966998967 0.0407500289748226 no 179 0.0413482960897353 307 1585493 YIL048W NEO1 SGTC_2330 7979373 200 µM 1.73462146617011 0.0408044884044566 no 180 0.0414039373743306 350 1863007 SGTC_514 4466-0038 2.65 nM 1.73366528910569 0.0408874933949945 no 181 0.0414887443691855 465 5722064 SGTC_1829 berberine 14.4 µM 1.73064012445556 0.041151008199805 no 182 0.0417579852720549 289 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_326 k292-0812 17.5 µM 1.72205553873674 0.0419062958556995 no 183 0.0425297290842001 254 3579357 SGTC_79 0052-0007 94.094 µM 1.71707365429283 0.0423497330235307 no 184 0.0429828576026927 314 2801472 SGTC_1998 st075797 76.8 µM 1.7118237564792 0.0428211258320663 no 185 0.0434645763363204 360 24208315 SGTC_2106 5357045 167.29 µM 1.71178467042514 0.0428246512414977 no 186 0.0434681790608175 337 668842 SGTC_3030 9087619 49.47 µM 1.71090800234993 0.0429037849321192 no 187 0.0435490485677647 305 25236973 SGTC_751 0833-0568 350 µM 1.7063142431977 0.0433203810309566 no 188 0.0439747938018345 301 6954252 SGTC_1214 0358-0031 63.7 µM 1.70582840424367 0.0433646308463325 no 189 0.0440200164941601 319 4301366 SGTC_2879 9041815 71.43 µM 1.70455714524797 0.0434805887691881 no 190 0.0441385248438168 201 4942971 SGTC_332 4112-0506 40.9 µM 1.70396576207619 0.0435346170359023 no 191 0.0441937419111029 307 2790355 SGTC_3195 9113082 49.47 µM 1.69800402409564 0.0440823082043256 no 192 0.0447535011677641 276 17018038 SGTC_537 1334-0398 209 µM 1.68873573861607 0.0449447828632905 no 193 0.0456350417700159 337 5846986 SGTC_2051 5263410 176 µM 1.68845370979536 0.0449712389448675 no 194 0.0456620838634597 322 227584 SGTC_2326 6164455 177.58 µM 1.68159563996467 0.0456184364737595 no 195 0.0463236383240906 322 2888790 SGTC_3275 9138069 49.47 µM 1.67633961461597 0.046119500098163 no 196 0.0468358447896186 297 17617007 SGTC_2808 7946468 45.46 µM 1.66977667873539 0.0467513485396896 no 197 0.0474817780841004 390 2970879 SGTC_3165 9101544 49.47 µM 1.664444026606 0.0472698489324406 no 198 0.0480118639951162 349 5002184 SGTC_2001 4023502 57.655 µM 1.66425761660441 0.0472880568436302 no 199 0.0480304791904029 359 108941 YCR052W RSC6 SGTC_438 sphingosine 6.67 µM 1.66121464817673 0.0475860794557964 no 200 0.0483351723387291 270 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes. SGTC_1683 st010134 710 nM 1.65923890594968 0.0477803841452366 no 201 0.0485338303270958 359 3818134 SGTC_2839 9003951 25.97 µM 1.64767189957166 0.0489307225930277 no 202 0.0497100087006948 311 2990634 SGTC_1347 1493-0251 600 nM 1.64243522162274 0.0494587359287162 no 203 0.0502499202911409 357 3986378 SGTC_3147 9097027 49.47 µM 1.64175915053302 0.0495272343108703 no 204 0.0503199639081179 347 25236841 SGTC_1366 1683-0113 21.9 µM 1.63957317753363 0.0497492317242696 no 205 0.0505469719377735 325 708623 SGTC_2889 9059656 51.95 µM 1.62751330035784 0.0509882839908073 no 206 0.051814063071723 373 3949838 SGTC_2658 polymyxin b sulfate 77.05 µM 1.62563656184495 0.0511832932930634 no 207 0.0520134962871984 373 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides.  YIL048W NEO1 SGTC_2243 6634756 200 µM 1.62534693176245 0.0512134411440987 no 208 0.0520443283236588 300 885676 SGTC_2770 toltrazuril 17.5 µM 1.62506918712368 0.0512423650981118 no 209 0.0520739087532381 368 68591 Kills coccidiodes. SGTC_3091 9116372 49.47 µM 1.62467536595231 0.0512833993837017 no 210 0.0521158744880017 338 17169793 SGTC_3324 9138759 60.749 µM 1.62110877114873 0.0516562130137246 no 211 0.0524971566114912 348 45595710 SGTC_3158 9100007 49.47 µM 1.62101579055959 0.0516659609502396 no 212 0.0525071261147655 305 19297233 SGTC_1077 5-fluorocytosine 377 nM 1.61493100055302 0.0523070661285897 no 213 0.0531628189911458 340 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_1798 st045719 60.953 µM 1.6129994451895 0.0525118942255572 no 214 0.0533723141625996 306 3980186 SGTC_450 aminopyrene 156 nM 1.61237206522013 0.052578560344114 no 215 0.0534404999528719 391 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1 SGTC_1120 ficusin 1.78878 µM 1.60635141433057 0.0532217421777423 no 216 0.0540983598045208 347 6199 A DNA cross-linker. SGTC_1148 3909-7663 27.7 µM 1.60623617386436 0.0532341137976135 no 217 0.0541110140471789 366 4084526 SGTC_2750 bromebric acid 70.15 µM 1.60078892777911 0.0538215070384936 no 218 0.0547118383879619 429 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2 SGTC_1189 1431-2119 7.28 µM 1.59627520182397 0.0543121142795702 no 219 0.0552136820553036 418 3107275 SGTC_666 0272-0154 136 µM 1.59104436612085 0.0548850844385518 no 220 0.0557997957583469 415 6870312 SGTC_3115 9123671 49.47 µM 1.58923329984371 0.0550845729224568 no 221 0.0560038655345997 331 3286988 SGTC_1994 st072947 40.9 µM 1.58406832114201 0.0556566414067165 no 222 0.0565890862189242 376 5286565 YDL195W SEC31 SGTC_2756 carbadox 75.1 µM 1.58303306192525 0.0557718679449134 no 223 0.0567069644631435 428 2553 A substituted quinoxaline antibiotic. YLR208W SEC13 SGTC_234 nsc-17383 10.7 µM 1.58222530506074 0.0558619036578572 no 224 0.0567990727618379 438 408974 SGTC_631 k072-0230 41.5 µM 1.57463591877913 0.0567134564918982 no 225 0.0576702534950554 413 5773147 SGTC_1656 st012921 11 µM 1.57350731220565 0.0568409584757155 no 226 0.0578006982560617 340 6732821 SGTC_2228 7354201 200 µM 1.569453844791 0.0573007527745358 no 227 0.0582711130351115 329 753451 SGTC_1427 4048-4900 550 nM 1.56568869527362 0.0577304596590632 no 228 0.058710757047269 376 24132586 SGTC_2771 fluoxetine 41.05 µM 1.56047204762805 0.0583300047719292 no 229 0.0593241852574702 357 3386 A selective serotonin reuptake inhibitor. SGTC_305 1682-2595 20.8 µM 1.55924126304702 0.0584721684379205 no 230 0.0594696439695288 380 226033 SGTC_1043 0916-0009 19.3 µM 1.55697834351568 0.058734260287726 no 231 0.0597378136130538 479 3101130 SGTC_1490 4089-0339 670 nM 1.55651928922491 0.0587875403862722 no 232 0.059792329737771 317 742542 SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM 1.55544928097505 0.0589118780551491 no 233 0.0599195525052393 486 551469 SGTC_1395 3486-0190 4.35 µM 1.55387167860536 0.0590955757206376 no 234 0.0601075142573586 398 6748079 SGTC_1336 1486-0901 104 µM 1.55213251812067 0.0592986057219634 no 235 0.0603152593229274 388 5006114 SGTC_163 TUB2.036 7.546 µM 1.55165788534971 0.0593541093544432 no 236 0.0603720523475754 575 15992207 YJR013W GPI14 SGTC_1978 st071761 42 µM 1.55041443064638 0.0594997122842138 no 237 0.0605210385665364 369 5147680 SGTC_778 3456-2434 196 µM 1.54704739553323 0.0598953824638734 no 238 0.0609259086583036 503 5539063 SGTC_880 0833-0487 87.2 µM 1.54270553904564 0.0604086455516971 no 239 0.0614511186696098 402 76075 SGTC_38 0929-0051 58.268 µM 1.53876168420303 0.0608778369115042 no 240 0.0619312435495506 437 1379719 SGTC_844 0330-0132 15.3 µM 1.53615707827077 0.0611892599018138 no 241 0.0622499300450926 392 2828079 SGTC_181 1447-1644 8.07 µM 1.53146388563928 0.0617535484389884 no 242 0.0628273926993503 396 534600 SGTC_1027 k015-0025 8.67 µM 1.5220180046983 0.0629015879179081 no 243 0.0640022846954692 427 3598955 SGTC_885 0865-0106 16.8 µM 1.52146100119848 0.0629698010726123 no 244 0.064072095406394 422 2793380 SGTC_2578 7,8-dihydroxyflavone 64.44 µM 1.52099510875808 0.0630269006015808 no 245 0.0641305323843674 411 1880 Intensifies effect of antibiotics on Staphylococcus aureus. SGTC_529 4076-0302 30.3 µM 1.52094306488662 0.0630332815740669 no 246 0.0641370628289908 418 5816522 SGTC_1723 st034307 2.5525 µM 1.51802473192907 0.0633918971313813 no 247 0.064504082005872 397 867466 SGTC_2764 methyldopa 94.69 µM 1.51748326298214 0.0634586091707217 no 248 0.0645723580255926 435 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent. SGTC_482 fipronil 114 µM 1.51570295672006 0.0636783382089212 no 249 0.0647972398397733 296 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels. SGTC_3136 9095672 49.47 µM 1.51245919768273 0.0640802108334041 no 250 0.0652085425284506 350 17217380 SGTC_826 1683-5028 118 µM 1.51155257824167 0.0641928846848267 no 251 0.0653238616655894 401 722377 SGTC_37 0566-0070 1.56 µM 1.51136592499416 0.0642161008876256 no 252 0.065347622997224 461 1626686 SGTC_2819 7996655 46.38 µM 1.51120770150363 0.0642357860663222 no 253 0.0653677704140468 363 6456960 SGTC_2741 miltefosine 3.04 µM 1.50804095430493 0.0646307600802798 no 254 0.0657720228059256 337 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis. SGTC_2703 st077852 53.4 µM 1.50485375001712 0.0650301876410845 no 255 0.0661808406158813 412 6281836 SGTC_3242 9133940 49.47 µM 1.50316662739865 0.065242395741168 no 256 0.0663980405005009 405 17248444 SGTC_1055 3448-0672 86 µM 1.50018087371801 0.0656192633351088 no 257 0.0667837781175277 415 748378 SGTC_1380 2291-0730 164 µM 1.49611618595949 0.0661350263627808 no 258 0.0673116903384373 393 2999191 SGTC_2700 st077718 96.8 µM 1.4954593498062 0.0662186653922935 no 259 0.0673973006353527 369 904970 SGTC_383 2324-0395 7.37 µM 1.49058706983316 0.0668416431359625 no 260 0.0680349705686142 449 3146421 SGTC_2135 5326629 150.42 µM 1.48906340922987 0.0670373887869691 no 261 0.0682353360233484 413 5020077 SGTC_3287 9117173 37.0625 µM 1.48739455557747 0.0672522958996688 no 262 0.0684553170037187 337 2789709 SGTC_1243 0416-0003 5.65 µM 1.48555583201162 0.0674896943591574 no 263 0.0686983225535688 442 2141977 SGTC_2534 helenine 20.12 µM 1.48449393381237 0.0676270912349339 no 264 0.0688389656445445 376 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58 SGTC_1488 4013-0813 75.9 µM 1.48252094145977 0.0678829464142794 no 265 0.0691008678396087 368 2910057 SGTC_2867 9039098 71.43 µM 1.48235906586203 0.0679039713764555 no 266 0.0691223898340817 450 6463460 SGTC_1288 0973-0013 65.5 µM 1.48068745294057 0.068121380429466 no 267 0.0693449394973455 430 4315430 SGTC_869 0564-0080 44.1 µM 1.47711217730146 0.0685881820641507 no 268 0.069822784931887 460 6843321 SGTC_334 1502-1024 68.5 µM 1.47028552216913 0.0694863444587471 no 269 0.0707422202465556 447 3296216 SGTC_2498 4'-Methoxychalcone 54.63 µM 1.46927103841506 0.069620586517943 no 270 0.0708796444565853 434 641818 YHR062C RPP1 SGTC_3347 9188721 44.724 µM 1.46809105027694 0.0697769801165197 no 271 0.0710397461494706 390 44118411 YKL104C | YBL026W GFA1 | LSM2 SGTC_809 3998-0021 90 µM 1.46377181431779 0.0703517513893959 no 272 0.0716281530298895 404 715485 SGTC_2073 5212005 126 µM 1.46295243639598 0.070461197669547 no 273 0.0717401971321718 325 691789 SGTC_1327 1436-0082 2.18 µM 1.45574184979618 0.0714299847960747 no 274 0.072731998108287 430 15992205 SGTC_1619 st003326 88.7 µM 1.45552070954441 0.0714598571266994 no 275 0.0727625805909027 400 2849032 SGTC_2328 6201408 200 µM 1.45232561353657 0.0718925315571267 no 276 0.0732055444021537 433 2890418 SGTC_1717 st033143 58.0435 µM 1.44565427397397 0.0728024261866578 no 277 0.0741370978159061 512 674616 SGTC_1470 k295-0292 231 µM 1.4435175537796 0.0730957070059978 no 278 0.0744373656195186 470 5045612 SGTC_1052 3253-3998 198 µM 1.44153866507395 0.0733681298801038 no 279 0.0747162810658829 513 5450317 SGTC_941 3237-0776 460 µM 1.43767144441412 0.0739027499894678 no 280 0.0752636495003808 422 760008 SGTC_3351 9150312 21.596 µM 1.43652739053968 0.0740614778314496 no 281 0.0754261640316399 478 4904905 SGTC_2482 5981709 142.65 µM 1.43554944322049 0.0741973661413597 no 282 0.0755652947824737 499 877755 SGTC_162 k030-0015 37.8 µM 1.43326108924048 0.0745160829058817 no 283 0.0758916187050942 443 1809920 YMR134W ERG29 SGTC_1002 4049-0206 172 µM 1.43147672778973 0.0747653290654885 no 284 0.0761468160534125 517 4662749 SGTC_2528 xanthyletin 44.79 µM 1.43098646450224 0.0748339221176922 no 285 0.0762170472146356 428 65188 An natural product with antifungal activity of unknown mechanism. SGTC_515 4092-1064 102 µM 1.42544292883616 0.075612865835612 no 286 0.0770146031506136 522 717353 SGTC_3054 9094397 49.47 µM 1.42454130555764 0.0757401383854858 no 287 0.0771449184659402 496 2598354 SGTC_2624 nerol 100 µM 1.42225294631783 0.0760638942849602 no 288 0.077476416656804 423 637566 A natural product oil. SGTC_2419 paclitaxel 166.5 µM 1.41748125576721 0.0767423781358752 no 289 0.0781711353965298 546 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_970 1315-0089 19.5 µM 1.41705593567653 0.076803076813232 no 290 0.0782332871094216 449 6811083 YLR033W RSC58 SGTC_651 3253-0966 34.4 µM 1.41568219937202 0.0769993761042772 no 291 0.0784342862062047 507 781462 SGTC_578 3460-0051 92 µM 1.41521890906568 0.0770656636327347 no 292 0.0785021610318299 521 2876744 SGTC_77 0828-0286 12.516 µM 1.41380493634514 0.077268242869994 no 293 0.0787095918990835 489 745345 SGTC_1008 4106-0037 6 µM 1.41372651794775 0.0772794896675227 no 294 0.0787211080820639 438 2905394 SGTC_1172 0370-0043 85 µM 1.41316383481798 0.0773602263836547 no 295 0.0788037787196587 438 376585 SGTC_325 2810-4341 181 µM 1.40346903219202 0.0787613682549868 no 296 0.0802385101275784 454 774970 SGTC_1099 5-nonyloxytryptamine 2.85 µM 1.39691421504251 0.07971954378638 no 297 0.0812196846986999 471 23581825 A 5-HT1D beta serotonin receptor agonist. SGTC_2280 7785178 200 µM 1.39436601153461 0.0800944083072736 no 298 0.0816035531593407 443 2954328 SGTC_3308 9128332 17.569 µM 1.3863961563618 0.0812754507016955 no 299 0.0828129847364932 592 17332805 YDL196W YDL196W SGTC_1603 st002045 67.8 µM 1.38162888227724 0.0819881595847768 no 300 0.0835428405192025 488 5887985 SGTC_2846 9008642 19.48 µM 1.38129306927297 0.0820385407127789 no 301 0.0835944341756258 448 2992898 SGTC_1684 st024538 14.6195 µM 1.37810426001798 0.082518112160357 no 302 0.0840855502475129 494 6732859 SGTC_2678 equilin 100 µM 1.37803579488212 0.0825284318627934 no 303 0.0840961184276944 499 3247 Equilin is an estrone commonly used hormone replacement therapy SGTC_3328 9140624 29.0385 µM 1.37733400064769 0.082634268845445 no 304 0.0842045038819508 492 4904392 SGTC_1064 honokiol 6.76 µM 1.37656907243615 0.0827497433266118 no 305 0.0843227591657824 512 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis. SGTC_749 1000-0129 128 µM 1.36962999761103 0.0838028269948879 no 306 0.0854012153201453 541 708470 SGTC_329 k048-0121 21.3 µM 1.36898763323145 0.083900819868261 no 307 0.085501570317973 478 6832902 SGTC_330 1488-0319 80.1 µM 1.36861914445449 0.0839570717652862 no 308 0.0855591782558313 482 6846614 SGTC_1733 st037357 54.9 µM 1.36802794196169 0.0840473813323884 no 309 0.0856516650072346 528 1272339 YGL099W LSG1 SGTC_1519 esterone 74 µM 1.36632090912936 0.0843085496867808 no 310 0.0859191305039928 515 698 A steroid. SGTC_536 3852-0578 10.6 µM 1.36529729336329 0.0844654501308559 no 311 0.0860798146739021 489 2869208 SGTC_2877 9040724 71.43 µM 1.36243219179211 0.0849057792826317 no 312 0.0865307650595968 480 6463895 SGTC_2618 avocadyne 43.43 µM 1.36206168358302 0.0849628470437305 no 313 0.086589209625486 472 3015189 SGTC_10 0279-0212 42.575 µM 1.35998877599856 0.0852826584764722 no 314 0.0869167378759146 633 39851 YBR002C RER2 SGTC_855 0428-0020 25 µM 1.35840354527961 0.0855278382930302 no 315 0.0871678349700862 461 6812414 SGTC_1017 4239-0030 168 µM 1.35354905589726 0.0862819414019617 no 316 0.0879401446644255 547 1149593 SGTC_3004 9076122 71.4286 µM 1.34888434994039 0.0870112375973164 no 317 0.088687057883585 521 44782551 SGTC_3267 9137951 49.47 µM 1.34617679468036 0.087436652661895 no 318 0.0891227534611943 439 16643986 SGTC_2021 4019055 173 µM 1.34311532059041 0.087919543892007 no 319 0.0896173177151815 689 44827708 YER133W GLC7 SGTC_2037 5169046 200 µM 1.34186473782139 0.0881173714636321 no 320 0.0898199284785666 478 5718022 SGTC_1648 st011736 69.8 µM 1.33988456621876 0.0884312898916645 no 321 0.0901414382604155 507 2855514 SGTC_345 1362-0200 395 µM 1.33922318332152 0.0885363249506589 no 322 0.0902490136748639 487 1419823 SGTC_180 1486-1293 102.781 µM 1.33645339916295 0.0889772076186322 no 323 0.0907005612540476 517 4140536 SGTC_1716 st033144 30.6155 µM 1.33478371404139 0.0892437694776172 no 324 0.0909735726209033 553 674617 SGTC_1682 st012968 530 nM 1.32720132443298 0.0904617616211552 no 325 0.092221047203348 486 24207270 SGTC_2668 2',4'-dihydroxychalcone 15.08 µM 1.32617590483168 0.0906274221276937 no 326 0.0923907192327604 502 5357218 A potent inhibitor of glutathione S-transferases. SGTC_505 gw-5074 63.9 µM 1.32372204260122 0.091024767084178 no 327 0.0927976875133582 544 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases. SGTC_1213 1315-0166 115 µM 1.32299675554592 0.0911424572217753 no 328 0.0929182283933619 459 768401 SGTC_2002 4023503 131 µM 1.32076969882011 0.0915045401922903 no 329 0.0932890830136957 659 4736863 YCR052W RSC6 SGTC_1512 0259-0544 12.2 µM 1.32001437498173 0.0916275852678607 no 330 0.0934151092993135 571 18476 SGTC_1960 st011366 51.8 µM 1.31462641285141 0.0925088627845221 no 331 0.0943177443819991 513 3972846 SGTC_2523 spermine 47.74 µM 1.31339355509196 0.0927113928646076 no 332 0.0945251840475549 514 1103 A DNA binding polyamine. SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM 1.31254193167329 0.0928514863170803 no 333 0.0946686738218422 330 4000243 SGTC_2514 salinomycin 42.74 µM 1.30700487365552 0.0937661605035946 no 334 0.0956055281393996 609 23682228 A polyether potassium ionophore. SGTC_3102 9121669 49.47 µM 1.30031263458158 0.094880517687609 no 335 0.0967469197241983 490 41905072 SGTC_2225 6654152 15.4 µM 1.29741213028455 0.0953665142356056 no 336 0.0972447104999658 456 97582 YGR029W | YLR033W ERV1 | RSC58 SGTC_55 0767-0285 6.563 µM 1.29506401904634 0.0957612944400782 no 337 0.0976490729403777 593 3116166 SGTC_113 0099-0221 2.5 µM 1.29467606854945 0.0958266348365547 no 338 0.0977159994403603 519 89219 SGTC_806 3966-4455 5.86 µM 1.2946165835458 0.0958366564718731 no 339 0.0977262643490319 481 714982 SGTC_144 4161-2749 112.381 µM 1.29264591169513 0.0961690980352234 no 340 0.0980667763867069 469 797501 YMR168C CEP3 SGTC_739 1486-1183 203 µM 1.28677235491935 0.0971649625321094 no 341 0.0990868226380467 570 4346692 SGTC_1263 0774-1208 64.8 µM 1.28087003034108 0.098173307375946 no 342 0.100119660531603 649 906585 SGTC_1853 st056710 91.2 µM 1.27985741838485 0.0983470682025872 no 343 0.10029764285306 578 269167 SGTC_1137 ixabepilone 100 µM 1.2788430567958 0.0985213549684171 no 344 0.100476164112774 624 154225 A novel microtubule stabilizer. SGTC_1883 5-benzylidenerhodanine 20 µM 1.27842946662781 0.0985924825466298 no 345 0.10054901987871 635 1273210 SGTC_237 nikkomycin 200 µM 1.27735026971937 0.0987782555011079 no 346 0.100739306730543 591 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine. SGTC_1588 farnesol 29.9 µM 1.27675945047891 0.098880067567109 no 347 0.100843592721181 558 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_759 3486-0358 89.3 µM 1.27618271049123 0.098979527483378 no 348 0.100945469476636 608 875103 SGTC_59 0330-0160 1.33 µM 1.27510001721743 0.0991664376286025 no 349 0.101136921652053 718 4293482 SGTC_3355 9151058 44.0485 µM 1.27386454301835 0.099380038192954 no 350 0.101355713127119 549 17015728 SGTC_2372 9071633 200 µM 1.27280361048994 0.0995637305840458 no 351 0.101543869841848 612 21321366 SGTC_1034 k072-0165 12.7 µM 1.2726765160966 0.0995857526426308 no 352 0.101566427122883 593 5835461 SGTC_2793 7325131 81.82 µM 1.27059035806234 0.0999477368911456 no 353 0.10193720945024 514 4176441 SGTC_2222 6885208 172.143 µM 1.27008721839165 0.100035183910819 no 354 0.102026782004742 506 609514 SGTC_3264 9137442 49.47 µM 1.2698553558548 0.100075501038882 no 355 0.102068079118619 525 17015726 SGTC_174 3553-0389 74.3 µM 1.26932422515064 0.100167900752359 no 356 0.102162724823159 529 738071 SGTC_946 3434-1334 87.4 µM 1.26878848960333 0.100261164637577 no 357 0.10225825575727 550 4047976 SGTC_2035 5154463 94.595 µM 1.26647282039568 0.100665018575697 no 358 0.102671927125877 594 2769623 SGTC_737 1950-0117 57.9 µM 1.26219899331471 0.101413489618765 no 359 0.103438595435588 557 5393513 SGTC_400 oxethazaine 37.5 µM 1.26107747807962 0.101610569223757 no 360 0.103640467048835 554 4621 A local anesthetic. SGTC_3064 1327-0027 10 µM 1.26031421759946 0.101744853475097 no 361 0.103778016546207 396 16000455 YPR107C YTH1 SGTC_1832 st054113 55 µM 1.2542213640743 0.102821434114105 no 362 0.104880778331608 534 1251267 SGTC_1745 st081495 74 µM 1.25242140218079 0.103141057782242 no 363 0.105208175845866 638 13842402 YBL026W LSM2 SGTC_50 0929-0078 56.389 µM 1.25200752763366 0.103214652426103 no 364 0.105283560508384 573 1377751 SGTC_1649 st011737 51.3 µM 1.25097436078265 0.103398535224503 no 365 0.10547191592221 571 1761035 SGTC_378 3970-0959 8.33 µM 1.24981081158838 0.103605908021861 no 366 0.105684332843209 583 6615653 SGTC_1345 1488-0192 31.4 µM 1.24945564636896 0.103669267190868 no 367 0.105749233189165 591 658348 SGTC_417 st075190 100 µM 1.24783105811604 0.103959441598136 no 368 0.106046466116209 615 222757 SGTC_143 4032-1194 15.74 µM 1.24778420489739 0.10396781897432 no 369 0.106055047277317 679 1806963 SGTC_453 enantio-paf c16 10 µM 1.24694856830021 0.104117313402108 no 370 0.106208178291676 750 13871343 A lipid and platelet activating factor SGTC_1552 6-methylflavone 10.6 µM 1.24575815681386 0.104330545689295 no 371 0.106426597777452 522 689013 SGTC_2821 7996764 71.43 µM 1.24422239512207 0.104606106067775 no 372 0.106708861799214 624 2987135 SGTC_1448 4255-0083 152 µM 1.2439467428515 0.104655621868649 no 373 0.106759582211729 593 5399660 SGTC_758 0868-0029 16 µM 1.23640450950818 0.106017037070949 no 374 0.108154120365243 589 762687 SGTC_2450 5739737 12.93 µM 1.23409899976197 0.106435737029679 no 375 0.108583008108348 575 2262825 SGTC_2892 9047358 58.44 µM 1.23278161917071 0.106675519794237 no 376 0.108828625412266 542 6466771 SGTC_2224 6650123 117.647 µM 1.23130327490363 0.106945064290794 no 377 0.109104728753486 544 2908370 SGTC_1310 1188-0297 994 nM 1.22993688288148 0.107194633294235 no 378 0.109360370644507 608 1588352 SGTC_2242 6630449 61.2675 µM 1.22891427644994 0.10738168505046 no 379 0.109551974087129 517 691249 YDR170C SEC7 SGTC_3098 9119039 49.47 µM 1.22774060383648 0.107596659178423 no 380 0.109772179420203 600 17161528 SGTC_1976 st070609 63.5 µM 1.22256649373423 0.108548064957275 no 381 0.110746737443736 634 682556 SGTC_3129 9127257 49.47 µM 1.22245299274122 0.108569002925858 no 382 0.1107681849422 516 837894 SGTC_3276 9139060 49.47 µM 1.22124302439072 0.108792391065179 no 383 0.110997009297191 553 4870619 SGTC_2193 5925765 200 µM 1.22082620203058 0.108869422597416 no 384 0.111075915421279 541 877370 SGTC_897 1000-0139 31.4 µM 1.21879220803163 0.109245880725768 no 385 0.111461534842922 602 6151020 SGTC_2987 9018338 71.43 µM 1.21795351961938 0.109401379885404 no 386 0.111620818165723 619 5055682 SGTC_848 0368-0089 85.6 µM 1.21502660284987 0.109945297726717 no 387 0.112177972595586 630 762535 SGTC_1905 st060207 84.5 µM 1.21478009212059 0.10999119600773 no 388 0.11222498784079 606 1948547 SGTC_2368 9071271 200 µM 1.2143541591302 0.110070533643097 no 389 0.112306256207982 588 27209959 SGTC_2011 4012611 177 µM 1.21231966502635 0.110450060965713 no 390 0.112695019551271 612 2049887 SGTC_3012 9080433 71.4286 µM 1.21176472447955 0.110553745731212 no 391 0.112801227538684 630 17688859 SGTC_477 mead ethanolamide 10 µM 1.21146950073681 0.110608933584708 no 392 0.112857758415067 439 16061185 SGTC_1529 apigenin 74 µM 1.21064917349556 0.110762385676759 no 393 0.113014944829835 648 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_1428 4049-0204 61.7 µM 1.20882031814434 0.11110504410328 no 394 0.113365941947891 623 X1428 SGTC_2723 salbutamol 83.58 µM 1.20868474195147 0.11113047615193 no 395 0.113391992889635 507 9884233 β2-adrenoceptor agonist SGTC_1014 4130-3005 69.3 µM 1.20751703470705 0.111349692999242 no 396 0.11361654439418 638 743608 SGTC_3018 9082602 49.47 µM 1.20062659606172 0.112649557113666 no 397 0.114948039746012 657 17332089 SGTC_3239 9133757 49.47 µM 1.19670943576078 0.113393333220239 no 398 0.115709913981765 612 17036923 SGTC_2871 9038510 12.99 µM 1.19613922407621 0.113501894291456 no 399 0.115821116558358 672 4945164 SGTC_2373 9071805 200 µM 1.18924859523329 0.114819644843817 no 400 0.117170928488061 632 10149009 SGTC_2952 9073731 13.78 µM 1.18613661287153 0.115418328470413 no 401 0.11778417683594 675 16457353 SGTC_1857 st056007 79.3 µM 1.18310020132224 0.116004608747425 no 402 0.118384719041011 599 619834 SGTC_933 2914-0560 114 µM 1.18230725387499 0.116158061172127 no 403 0.118541904185092 696 463887 SGTC_1596 piperlongumine 63 µM 1.17982811493967 0.116638757137071 no 404 0.119034292520971 707 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_2810 7959871 45.46 µM 1.17616549182077 0.117351504998674 no 405 0.11976437558787 690 2974535 SGTC_149 3970-0822 46.1 µM 1.17151401284744 0.118261123258915 no 406 0.120696114308012 787 3114250 YBL034C STU1 SGTC_1489 4065-0444 182 µM 1.16957922182737 0.118640944888279 no 407 0.121085171529805 616 2877968 SGTC_1724 st037281 8.293 µM 1.16508355431066 0.119526821904149 no 408 0.121992586554764 656 574124 YDL195W SEC31 SGTC_507 nimesulide 162 µM 1.15933213153173 0.12066693663037 no 409 0.123160414631662 671 4495 A COX2 inhibitor. SGTC_2767 sibutramine 71.45 µM 1.15769342789877 0.120993176666576 no 410 0.123494583451945 660 64765 A serotonin-norepinephrine reuptake inhibitor.  SGTC_1765 st044815 90.4 µM 1.15454036621437 0.121622646213843 no 411 0.124139349599723 644 645695 SGTC_786 4544-0069 423 µM 1.15432220267467 0.121666284826212 no 412 0.124184048577635 687 748821 YLR208W SEC13 SGTC_483 fpl-64176 144 µM 1.15430813364187 0.121669099391166 no 413 0.124186931532724 603 3423 SGTC_1590 st077108 57.8 µM 1.15415279663029 0.121700178208482 no 414 0.124218765520233 639 5489485 SGTC_1273 0849-0096 14.1 µM 1.1529224093347 0.12194654317606 no 415 0.124471116592063 670 5286025 SGTC_1614 st002383 48.6 µM 1.15285295216735 0.121960461277996 no 416 0.124485372860926 668 1947235 SGTC_1787 fluconazole 80 µM 1.15271033073253 0.121989043822786 no 417 0.124514649869615 702 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C SGTC_3026 9090633 49.47 µM 1.15234051227148 0.12206318049278 no 418 0.124590587798734 658 25236842 SGTC_3057 9095946 49.47 µM 1.14939846472061 0.122654093252122 no 419 0.125195856417743 668 24540043 SGTC_810 3825-7150 143 µM 1.14378385566142 0.123787354725269 no 420 0.126356643387384 721 22330411 YGL099W LSG1 SGTC_2442 5158906 48.48 µM 1.14112239362359 0.124327101463507 no 421 0.126909496791814 689 1893835 SGTC_668 1682-0499 62.6 µM 1.13663459726374 0.125240953771677 no 422 0.127845535353662 717 682214 SGTC_2348 9022543 33.42 µM 1.1343818667425 0.125701442198686 no 423 0.128317201010265 691 3162678 YDL140C RPO21 SGTC_2961 9083290 32.55 µM 1.13370247521906 0.125840550508675 no 424 0.12845968551123 620 17741490 SGTC_522 1273-0010 11.6 µM 1.13063631559366 0.126469695352037 no 425 0.129104097933506 653 5705015 SGTC_1251 0490-5699 265 µM 1.13020261213666 0.126558863492227 no 426 0.129195429676818 731 3883818 SGTC_1357 1503-1303 39.5 µM 1.12872683978593 0.126862605879023 no 427 0.129506541674204 716 292895 SGTC_2104 5389443 200 µM 1.12728150807945 0.127160574536207 no 428 0.12981173911412 722 2244536 SGTC_172 1112-0046 2.638 µM 1.1264589989878 0.127330359723244 no 429 0.129985642993028 595 2802135 YIL048W NEO1 SGTC_3063 1327-0034 4 µM 1.12636148285223 0.127350499793947 no 430 0.130006271610489 658 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_385 1494-0393 12.4 µM 1.12552617489151 0.127523107268294 no 431 0.130183065960684 706 3090647 SGTC_312 4092-0653 6.84 µM 1.12451718527979 0.12773182103846 no 432 0.130396842083512 783 1148278 SGTC_2292 7671323 168.05 µM 1.12062311740877 0.128539551308041 no 433 0.131224160274428 687 937504 SGTC_2614 arthonioic acid 13.39 µM 1.1169740995113 0.129299663042454 no 434 0.132002699817945 633 6710684 SGTC_1233 0325-0408 14.2 µM 1.11548343013876 0.129611072670006 no 435 0.132321657585285 689 12874 SGTC_2044 5102272 200 µM 1.11386484130637 0.129949793307833 no 436 0.132668587309766 633 592666 SGTC_704 1310-0270 142 µM 1.11342910338251 0.130041084389066 no 437 0.132762090695787 712 5718033 SGTC_1736 st036774 51 µM 1.11192060730988 0.130357470909775 no 438 0.133086143758958 729 1272247 SGTC_2529 gangaleoidin 93.61 µM 1.11060744218734 0.130633322608382 no 439 0.133368678986892 698 4565183 SGTC_1084 voriconazole 435 nM 1.11023827807394 0.130710944161915 no 440 0.13344818107612 712 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_2188 6126565 140.678 µM 1.10967030902642 0.130830429289905 no 441 0.133570560851971 653 874518 SGTC_892 0929-0076 29 µM 1.10770076347795 0.13124535237834 no 442 0.133995534772574 732 5751038 SGTC_1016 4226-1401 38 µM 1.10702642350109 0.131387623834637 no 443 0.134141252125638 710 2901613 SGTC_1843 st055809 45.5 µM 1.10672473058878 0.13145130911459 no 444 0.134206479833737 677 16413835 SGTC_354 2783-3500 4.88 µM 1.10642308089913 0.131515006573511 no 445 0.134271719974752 683 6740761 SGTC_1943 st076331 65.2 µM 1.10615408549856 0.131571826601073 no 446 0.134329916085917 730 24208415 SGTC_295 k015-0027 31 µM 1.10523222890941 0.131766679330901 no 447 0.134529487565132 697 3887424 SGTC_2887 9044784 58.44 µM 1.09974450237007 0.132930739392219 no 448 0.135721729483066 767 6465546 SGTC_909 3448-9333 149 µM 1.09855709598304 0.133183541675028 no 449 0.135980650209728 659 3344074 SGTC_297 0986-0032 24 µM 1.09635165320368 0.133653964348196 no 450 0.136462456444535 680 2847425 SGTC_868 0527-0199 213 µM 1.09517630036892 0.133905134149412 no 451 0.136719703209284 733 2849450 SGTC_1474 0330-0125 5.35 µM 1.09260160328276 0.134456473180825 no 452 0.137284379240925 720 X1474 SGTC_1169 aniline yellow 25.8 µM 1.09082360874839 0.134838116895495 no 453 0.137675252994527 676 6051 A DNA damaging agent. SGTC_1103 duloxetine 36.1 µM 1.09011963223595 0.134989429526809 no 454 0.137830224658285 794 60835 A selective serotonin reuptake inhibitor. SGTC_3081 9117243 49.47 µM 1.08925936811721 0.135174492659014 no 455 0.138019762619233 698 45595589 SGTC_887 0885-0007 9.62 µM 1.08823443383312 0.13539520722726 no 456 0.138245813552915 743 5719458 SGTC_2352 9027995 87.8 µM 1.08609982748886 0.135855676755239 no 457 0.138717414342497 657 2997347 SGTC_1370 2001-0092 44.6 µM 1.08508992973314 0.136073901495518 no 458 0.13894091351842 826 790957 SGTC_2314 7727897 200 µM 1.08325116067056 0.136471849571381 no 459 0.13934847844335 692 900724 SGTC_215 1287-0124 461.5 µM 1.0831440416532 0.136495056879061 no 460 0.13937224652262 693 5560863 SGTC_2943 9068529 45.32 µM 1.08262198239702 0.136608199516302 no 461 0.139488122998302 772 3270634 SGTC_2342 7990637 118.86 µM 1.07886296060154 0.137424762050465 no 462 0.140324411342226 745 2033102 YER133W GLC7 SGTC_2226 7298446 200 µM 1.0749754253895 0.138272740099663 no 463 0.14119286541872 682 3283010 SGTC_129 0088-0017 176.636 µM 1.07104488198612 0.13913371874159 no 464 0.142074624735369 701 182446 SGTC_1085 doxorubicin 7.67 µM 1.07033537762189 0.139289522361803 no 465 0.142234187833019 782 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_729 4092-0585 94.1 µM 1.06782633001603 0.139841448654953 no 466 0.142799429341532 677 2169061 SGTC_2679 rapamycin 1 nM 1.06453558865694 0.140567578175676 no 467 0.143543070619247 815 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2 SGTC_2014 4013930 200 µM 1.06434876772397 0.140608878406872 no 468 0.143585366659559 813 64556 SGTC_1622 st003707 19.4 µM 1.06407781709711 0.140668791700167 no 469 0.143646724509533 773 10140899 SGTC_374 0880-0231 82.3 µM 1.06220878431188 0.141082548928983 no 470 0.144070456431487 741 6833587 SGTC_2446 5162541 200 µM 1.0609181807517 0.141368737593219 no 471 0.144363543060046 697 1549321 SGTC_2644 guaiazulene 100 µM 1.0608435626579 0.141385296024647 no 472 0.144380500562811 736 3515 A coloring agent. SGTC_923 1900-2434 73.3 µM 1.06012067604637 0.141545779168713 no 473 0.144544851283651 713 5910570 SGTC_2227 7312221 64.1025 µM 1.04912803869032 0.144001390027619 no 474 0.147059596472127 766 887188 YOR168W | YOR169C GLN4 | YOR169C SGTC_1572 epiandrosterone 68.9 µM 1.04687152154791 0.144508999452625 no 475 0.147579419038184 800 441302 A steroid. SGTC_2491 paeonol 100 µM 1.04563876724647 0.144786819380418 no 476 0.147863921746647 727 11092 Increases levels of cortical cytochrome oxidase. SGTC_1569 carminic acid 40.6 µM 1.04313776051772 0.14535156373781 no 477 0.148442247148289 774 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_2078 5212016 200 µM 1.04286261802076 0.145413783143346 no 478 0.148505962523584 724 1899708 SGTC_2219 9098279 200 µM 1.04243088011763 0.145511450388741 no 479 0.14860597791059 752 902349 SGTC_2294 7971431 200 µM 1.04198148569954 0.145613158718385 no 480 0.148710131386637 682 5741572 SGTC_485 niflumic acid 177 µM 1.04082753286042 0.145874543793153 no 481 0.148977799645699 726 4488 A COX2 inhibitor. SGTC_1140 3229-1848 2.98 µM 1.04058075054319 0.145930484046577 no 482 0.149035084459159 777 2849525 SGTC_1059 3448-6867 171 µM 1.04029501179152 0.145995272893237 no 483 0.149101430488343 784 3934407 SGTC_612 0302-0167 22.4 µM 1.03952242920976 0.146170546221869 no 484 0.149280916145505 849 235821 SGTC_1420 4'-methoxyflavone 42 µM 1.03625592257183 0.146913169648101 no 485 0.150041381775569 780 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13 SGTC_1449 4112-4002 201 µM 1.0327537364449 0.147712179941882 no 486 0.15085957951425 722 2059539 SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM 1.03238116317557 0.147797352043473 no 487 0.150946796352601 830 5024745 SGTC_1356 1502-0781 85.8 µM 1.03228649148111 0.147818999702049 no 488 0.150968963690947 751 567702 SGTC_2299 7976368 114.88 µM 1.0321385011831 0.147852843461757 no 489 0.151003619898707 757 2979718 SGTC_2875 9039966 71.43 µM 1.03148448635997 0.148002471606208 no 490 0.151156839777365 751 6463691 SGTC_2725 haloperidol 53.21 µM 1.03031930960396 0.148269296486985 no 491 0.151430068753785 765 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_982 1491-0518 27.5 µM 1.03023150086492 0.148289417674946 no 492 0.151450672827114 717 3091256 SGTC_2686 alizarin 95.37 µM 1.02913224518183 0.148541464371328 no 493 0.151708767810037 702 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1 SGTC_1 0258-0098 57.368 µM 1.02751209665354 0.148913467735588 no 494 0.152089696174484 676 6790032 YDR047W HEM12 SGTC_3241 9133421 49.47 µM 1.02732420160434 0.148956650688211 no 495 0.152133915016948 764 17018221 SGTC_1754 st042065 16.137 µM 1.02673154117793 0.149092913594216 no 496 0.152273446455455 871 1126236 YIL048W NEO1 SGTC_1997 st073024 93.8 µM 1.02284624506818 0.149988272088455 no 497 0.153190274412133 783 686268 SGTC_1735 st034310 56.75 µM 1.02126273350746 0.150354215364349 no 498 0.15356498874199 769 871153 SGTC_1113 artemisinin 1.17947 µM 1.01712401286602 0.151313464664431 no 499 0.154547219161323 831 2240 An anti-malaria and mitochondrial poison. SGTC_1809 st050081 57.6 µM 1.01610547270805 0.151550158902355 no 500 0.154789581618859 788 5036894 SGTC_2436 5633522 8.09 µM 1.01430113080783 0.151970066216994 no 501 0.155219542317098 801 5724242 SGTC_1177 0983-0204 23.6 µM 1.01400980917343 0.152037935121104 no 502 0.15528903585288 839 766818 SGTC_2474 5321570 43.32 µM 1.01301946303126 0.152268805570851 no 503 0.155525432246424 794 2841384 SGTC_2355 9061122 103.12 µM 1.01049401179489 0.152858594183378 no 504 0.156129333476652 790 5302957 SGTC_2768 sulfasalazine 50.2 µM 1.00955299014104 0.153078745297479 no 505 0.156354750896356 788 5384001 An antioxidant and salicylic acid derivative. SGTC_1852 st056254 31.4 µM 1.00556843404044 0.154013256341034 no 506 0.157311607341386 771 442583 SGTC_1260 0700-1617 7.75 µM 1.00480055037991 0.154193783518603 no 507 0.157496449409268 810 2853078 SGTC_2714 st079313 56.9 µM 1.00458599714493 0.154244249355431 no 508 0.157548121358641 779 2939799 SGTC_1119 parthenolide 318.541 nM 1.00452602806714 0.154258356850602 no 509 0.157562566009088 860 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs. SGTC_344 k064-0035 6.43 µM 1.00287958347281 0.154646009926342 no 510 0.157959482241585 773 5088750 SGTC_2735 sertaconazole 140 nM 1.00245537881637 0.154745992529074 no 511 0.15806185354641 756 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C SGTC_2526 patulin 37.61 µM 0.99990658167715 0.155347628426031 no 512 0.158677859486558 837 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.  SGTC_1303 1160-0052 261 µM 0.999195937332525 0.155515648713053 no 513 0.158849891776722 810 3562476 SGTC_1220 1838-0075 193 µM 0.999049267000009 0.155550341445313 no 514 0.158885412842123 817 5529645 SGTC_2145 5634607 200 µM 0.99752768770156 0.155910550071883 no 515 0.159254220631024 741 308662 SGTC_360 0957-0399 1.01 µM 0.997118164364979 0.15600759175775 no 516 0.159353578567222 826 6752301 YPR165W RHO1 SGTC_2353 9059630 146.67 µM 0.996420196298532 0.15617307575955 no 517 0.159523012050181 812 4779114 SGTC_398 bronopol 33.3 µM 0.994503892146021 0.156628014334738 no 518 0.159988805741722 812 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them. SGTC_551 k048-0028 34.9 µM 0.991748592039813 0.157283661463313 no 519 0.160660090377369 855 6836383 SGTC_2525 harmine 47.85 µM 0.990225725125111 0.157646813755069 no 520 0.161031900632113 773 5280953 A monoamine oxidase inhibitor SGTC_698 k064-0052 127 µM 0.989628575837534 0.15778936391233 no 521 0.16117784868116 823 5088751 SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM 0.98536138710647 0.158810481064824 no 522 0.162223294601407 844 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_2165 5727197 32.143 µM 0.983713443100869 0.159205982717726 no 523 0.162628214082474 762 1361712 SGTC_840 0245-0196 390 µM 0.980008328102804 0.160097552993636 no 524 0.16354100388127 875 3827528 SGTC_2403 6032726 181.2 µM 0.979300466576849 0.160268258027932 no 525 0.163715769994921 780 2881040 SGTC_896 0964-0007 44.5 µM 0.978488576842087 0.160464196507266 no 526 0.163916369169276 839 6756758 SGTC_1289 0976-0073 69.1 µM 0.978423905203424 0.160479810849525 no 527 0.163932354890703 864 3391136 SGTC_2068 5226020 147 µM 0.977581994209476 0.160683172697478 no 528 0.164140553167911 859 1810509 SGTC_1439 4092-1168 46 µM 0.977185670071763 0.160778962202125 no 529 0.164238620499016 837 2886240 SGTC_592 k241-0073 46.5 µM 0.976537203533967 0.16093577362383 no 530 0.164399160435277 891 4230158 SGTC_2984 9022109 38.96 µM 0.973850609057908 0.161586505967508 no 531 0.165065360185705 811 6459207 SGTC_1089 terbinafine 2.25 µM 0.970770975805691 0.162334545104779 no 532 0.165831169423265 838 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_2398 5228213 48.84 µM 0.970318760189772 0.162444577224552 no 533 0.165943814491723 916 80771 YMR134W ERG29 SGTC_604 1000-0114 314 µM 0.968850830918373 0.162802084993936 no 534 0.166309810399096 897 1572745 SGTC_495 decylubiquinone 155 µM 0.967535279411095 0.163122916258406 no 535 0.166638256852107 768 2971 A Co-enzyme Q analog. A free radical scavenger. SGTC_1277 0873-0036 22 µM 0.965798336916276 0.163547143607903 no 536 0.167072550433058 865 5965735 SGTC_99 0109-0120 622.8 µM 0.965462324262158 0.163629293293237 no 537 0.167156648982525 804 759414 SGTC_3088 9117578 49.47 µM 0.965156387624967 0.16370411317383 no 538 0.167233243722274 845 678341 SGTC_2274 7947094 46.08 µM 0.964681546309952 0.163820284370302 no 539 0.167352170481425 889 2971028 SGTC_849 0386-0493 241 µM 0.963991397978195 0.163989226375946 no 540 0.167525119281556 820 726119 SGTC_586 0957-0265 8.15 µM 0.959255034973803 0.165151693251472 no 541 0.168715140733408 771 6752309 YPR165W | YPR107C RHO1 | YTH1 SGTC_1926 methyl fluorone black 53.6 µM 0.955089445286846 0.166178470216578 no 542 0.169766233028669 770 72721 Reacts with homocysteine. SGTC_939 1165-0479 45.3 µM 0.952804818317081 0.166743355558011 no 543 0.170344486278001 861 1377347 SGTC_1799 st045822 46.1415 µM 0.951120164587673 0.167160687238604 no 544 0.17077168977906 845 3674992 SGTC_2266 7929956 200 µM 0.94947242384157 0.16756952547286 no 545 0.171190195398019 854 2967153 SGTC_3258 9138477 49.47 µM 0.949329301328679 0.167605067478637 no 546 0.171226577664261 860 4970355 SGTC_2662 daunorubicin 22.37 µM 0.94916366170425 0.16764620728166 no 547 0.171268690034044 816 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_2957 9076800 11.52 µM 0.94890015790259 0.1677116669467 no 548 0.171335697127015 764 16459615 SGTC_442 cape 100 µM 0.947933772576634 0.167951877428882 no 549 0.171581585271605 834 5281787 SGTC_2434 5670830 169.91 µM 0.947182480076852 0.168138776085422 no 550 0.171772900660951 836 1549830 SGTC_1042 0350-0096 82 µM 0.943878640221373 0.168962258103489 no 551 0.172615834154318 827 3122515 SGTC_2776 terbinafine 19.92 µM 0.942397728325712 0.169332214818667 no 552 0.172994524924454 840 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_2141 5621638 7.665 µM 0.940356138462264 0.16984309013895 no 553 0.173517456335272 868 2856238 SGTC_1132 3456-3614 2.5 µM 0.939789395850294 0.169985083517181 no 554 0.173662799603976 955 3125502 SGTC_1685 st024049 53.0905 µM 0.938402417875267 0.170332901986568 no 555 0.174018821927992 847 1941139 SGTC_2 0422-0095 29 µM 0.937014975262413 0.170681292760091 no 556 0.174375427432703 748 6790840 SGTC_1413 3910-0535 34.4 µM 0.935901262233755 0.170961279044849 no 557 0.174662013625743 914 2876951 SGTC_2281 7943571 200 µM 0.934228491315607 0.171382363655983 no 558 0.17509302093685 958 1244024 SGTC_2755 lomerizine 42.69 µM 0.931208467910197 0.172144267821685 no 559 0.175872869223717 885 3949 A calcium channel blocker. SGTC_1290 0986-0249 10.2 µM 0.928586428373578 0.172807517332945 no 560 0.176551728964588 843 53329 SGTC_2880 9042983 58.44 µM 0.927592904677458 0.173059255814404 no 561 0.176809389807919 859 6464714 SGTC_2003 4023581 200 µM 0.927013142881386 0.173206263414344 no 562 0.176959855235185 854 16641307 SGTC_1884 5633444 25 µM 0.926508262535619 0.17333434842213 no 563 0.177090952591791 886 5724239 SGTC_569 4130-2812 160 µM 0.924278672625595 0.173900702446378 no 564 0.177670621940656 784 743552 SGTC_2920 7982904 15.77 µM 0.923262892380325 0.174159117772354 no 565 0.177935110379774 823 6456808 SGTC_2745 rifampicin 24.3 µM 0.92190251539654 0.17450558088305 no 566 0.178289713490764 752 25141428 Inhibits bacterial DNA-dependent RNA polymerase. SGTC_837 0091-0265 12.5 µM 0.916417572594941 0.175906931995526 no 567 0.179723961024001 906 759367 SGTC_3320 9137005 35.139 µM 0.913401142853926 0.17668063013168 no 568 0.180515802364938 844 4908713 SGTC_2652 actinonin 100 µM 0.913367123079707 0.176689368274351 no 569 0.180524745338346 870 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase. SGTC_2301 7769476 200 µM 0.908747990171745 0.17787835141241 no 570 0.181741582966277 864 977820 SGTC_1453 4237-0541 195 µM 0.907461379160094 0.178210426668385 no 571 0.182081431936334 923 739892 SGTC_1141 3253-0389 52.6 µM 0.904488719626386 0.178979165415364 no 572 0.182868156577278 909 5402031 SGTC_3256 9138902 49.47 µM 0.901139157208319 0.179847868648109 no 573 0.183757167810705 955 17228773 SGTC_1122 capsaicin 818.572 nM 0.898126684470611 0.180631406237028 no 574 0.184559007121035 917 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_3201 9113999 49.47 µM 0.897313521061433 0.180843274619588 no 575 0.184775821773975 862 16649224 SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM 0.89707331399507 0.180905889964427 no 576 0.184839898728787 965 676296 Flavone; oxidizing agent. SGTC_3 0833-0587 95.581 µM 0.896637373240975 0.181019562374218 no 577 0.184956224317724 908 5382644 SGTC_1349 flufenamic acid 69 µM 0.895912597594084 0.181208648080668 no 578 0.185149722707748 881 3371 A non-steroidal anti-inflammatory. SGTC_9 0092-0002 10.449 µM 0.895555682882138 0.181301808504057 no 579 0.185245056896199 910 759368 SGTC_65 0798-0905 34.986 µM 0.89254933703216 0.182087702472909 no 580 0.186049280273343 979 3602145 SGTC_1815 st051655 58.2 µM 0.892298231909557 0.182153440520949 no 581 0.186116550855586 912 5984156 SGTC_270 tamoxifen 5.46 µM 0.891890788019226 0.182260138825994 no 582 0.18622573636849 983 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  YIL048W NEO1 SGTC_2556 citropten 84.59 µM 0.891555617045479 0.182347940123983 no 583 0.186315584166173 985 2775 A potential DNA crosslinker. SGTC_1525 8-methoxypsoralen 92.5 µM 0.890453114732277 0.182636937732103 no 584 0.186611316501241 995 4114 Related to psoralen; DNA damaging agent. SGTC_3254 9136651 49.47 µM 0.890282689836227 0.182681636514663 no 585 0.186657056752104 973 16454030 SGTC_3107 9121808 49.47 µM 0.889449268629109 0.182900323324066 no 586 0.186880838199756 903 662681 SGTC_2031 5180455 200 µM 0.887198585772467 0.183491710552923 no 587 0.187485996854841 895 29949 SGTC_2190 6049624 200 µM 0.887190199531661 0.183493916339805 no 588 0.18748825399114 870 2265554 SGTC_1320 1313-0481 95.3 µM 0.885592627438794 0.183914418393376 no 589 0.187918542910626 977 6813365 YLR208W SEC13 SGTC_1429 4049-0205 9.46 µM 0.884999364244605 0.184070725777097 no 590 0.18807848712577 962 22774478 SGTC_2931 9014674 55.67 µM 0.884482673975941 0.184206925807381 no 591 0.188217855657276 922 2996810 SGTC_2946 9065502 71.43 µM 0.884482321501909 0.184207018741262 no 592 0.188217950752978 762 16489101 SGTC_2468 5987765 72.9 µM 0.884310499264067 0.184252325148794 no 593 0.188264311048949 977 26772094 SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM 0.883799243698784 0.18438717497761 no 594 0.188402297368901 927 279621 SGTC_108 0509-0257 621.132 µM 0.882800828864336 0.184650695924158 no 595 0.18867194629423 947 536624 SGTC_672 1441-0018 53.7 µM 0.882123867286923 0.184829505860236 no 596 0.188854913344195 882 251141 SGTC_1783 st039459 87.517 µM 0.882035495190507 0.18485285605305 no 597 0.188878806342382 991 729761 SGTC_1708 st033234 31.827 µM 0.881086330756504 0.185103765421369 no 598 0.189135547572566 998 674664 SGTC_827 3253-0474 693 µM 0.880728616286304 0.185198381256537 no 599 0.189232362149979 974 5402065 SGTC_2492 derrusnin 100 µM 0.8805629573878 0.185242208374768 no 600 0.189277207675208 855 1715307 Part of coumarin class of compounds. SGTC_2897 9048598 12.99 µM 0.877952133515272 0.185933784662243 no 601 0.189984847751217 908 6467404 SGTC_2869 9037858 32.47 µM 0.876882978357819 0.186217452634488 no 602 0.190275101261705 950 27187042 SGTC_716 1683-5115 658 µM 0.876581124554301 0.186297588930847 no 603 0.190357097611103 1021 723597 SGTC_253 dyclonine 31.25 µM 0.874983381398685 0.186722114347259 no 604 0.190791474058936 990 3180 An oral anasthetic. SGTC_1800 st050079 29.0735 µM 0.874237773326604 0.186920429544723 no 605 0.190994389575922 1000 3645560 SGTC_1074 carmofur 3.8 µM 0.873555528344794 0.187102005708149 no 606 0.19118017689771 1010 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_2371 9071574 200 µM 0.872267452165704 0.187445118188092 no 607 0.19153124466204 926 45596039 SGTC_2695 st077686 51.995 µM 0.870911814279114 0.187806647212426 no 608 0.191901152760251 912 2876092 SGTC_2389 9091542 195.52 µM 0.869593037612609 0.188158758812987 no 609 0.192261421994499 928 3626624 YOL127W RPL25 SGTC_2604 4'-hydroxychalcone 11.32 µM 0.868827758745406 0.188363273918665 no 610 0.192470673813518 906 5282362 SGTC_919 tnp00227 403.569 nM 0.866957114175071 0.188863766770333 no 611 0.192982753950666 963 1269246 A methoxyflavone. YNL221C POP1 SGTC_1776 st049249 45.9 µM 0.866476092627855 0.188992596899239 no 612 0.193114565690988 978 1822314 SGTC_1106 tegaserod maleate 11.7 µM 0.865847899608609 0.189160924881194 no 613 0.193286788774854 953 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation. SGTC_83 0170-0301 39.027 µM 0.864770922665072 0.189449721862131 no 614 0.193582266819485 903 3089716 SGTC_413 propylparaben 100 µM 0.864598035763925 0.189496107648221 no 615 0.193629725501126 924 7175 A pharmaceutical preservative. SGTC_2128 5255449 168.493 µM 0.863803150910211 0.189709466233393 no 616 0.193848018325697 1005 736008 SGTC_762 1165-0429 115 µM 0.863725042974947 0.189730439502004 no 617 0.193869476569858 957 5967793 SGTC_585 0kpi-0023 191 µM 0.86340627459181 0.18981604885437 no 618 0.193957065393833 924 64601 SGTC_2649 anisomycin 9.56 µM 0.862956071889472 0.18993699704052 no 619 0.194080809840708 939 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_2978 9011784 42.97 µM 0.860985138737776 0.190467051122412 no 620 0.194623114070546 1060 2994934 SGTC_597 k018-0003 82.8 µM 0.860969471104621 0.190471268342306 no 621 0.194627428726155 1050 6786234 SGTC_1153 4055-0057 267 µM 0.860275140036093 0.190658217368759 no 622 0.194818696609479 970 882706 SGTC_1547 harmine 94.2 µM 0.856032796163098 0.191802915452973 no 623 0.195989819553118 1037 5280953 A monoamine oxidase inhibitor YHR072W ERG7 SGTC_171 k064-0041 9.68 µM 0.85566077686374 0.191903496514351 no 624 0.196092720859374 871 53325 SGTC_715 0868-0130 184 µM 0.855110388201617 0.19205236164366 no 625 0.196245019586634 964 2876258 SGTC_230 MPP+ 141.667 µM 0.854235665233627 0.192289095710052 no 626 0.19648721277219 913 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death. SGTC_2885 9057732 51.95 µM 0.853614681717426 0.192457266286084 no 627 0.196659260495446 982 6471414 SGTC_510 ag-490 170 µM 0.852239943170649 0.192829883478772 no 628 0.197040465686519 1071 5328779 SGTC_661 1304-0007 33.6 µM 0.851591307155899 0.193005846505577 no 629 0.197220483005896 932 3117130 SGTC_2174 5790901 200 µM 0.851338618534646 0.193074422814718 no 630 0.197290639133959 926 786020 SGTC_2343 7990716 14.84 µM 0.851112539841666 0.193135790153112 no 631 0.19735342011077 971 6456862 SGTC_2783 7738165 71.43 µM 0.850518591249368 0.193297069698081 no 632 0.197518414368245 865 17201110 SGTC_1362 1611-0397 101 µM 0.85012754956616 0.193403297184645 no 633 0.197627088193159 978 27816 SGTC_912 3474-0017 2.18 µM 0.845259687365994 0.194728644050724 no 634 0.198982931762465 992 3360550 SGTC_981 1488-1094 54.9 µM 0.844661264981954 0.194891953824112 no 635 0.199149996133229 938 3449522 SGTC_1268 0828-0275 2.46 µM 0.844624694692738 0.194901936574394 no 636 0.19916020837042 1019 745337 SGTC_2099 5377090 177.372 µM 0.842639252448217 0.195444377951323 no 637 0.199715115589834 942 2243829 SGTC_836 0330-0104 1.35 µM 0.84236710646264 0.195518802170976 no 638 0.19979124954039 994 46494820 SGTC_785 1270-0111 65.3 µM 0.840260011076185 0.196095615373586 no 639 0.200381308724933 1030 6741994 SGTC_1641 st009299 47.1 µM 0.838792633225132 0.196497916137082 no 640 0.200792842679018 948 4046054 SGTC_1222 0366-0074 1.18 µM 0.83853637999178 0.196568222561816 no 641 0.200864762258059 1040 286520 SGTC_256 clotrimazole 625 nM 0.838346536482968 0.19662031843716 no 642 0.200918053367864 968 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C SGTC_2079 5212404 121 µM 0.838075056825685 0.196694831013791 no 643 0.200994275357998 1009 758462 SGTC_2098 5376439 882.5 nM 0.838069999851081 0.19669621915557 no 644 0.200995695344102 1032 2844116 SGTC_139 0099-0334 718.624 µM 0.836912149816032 0.197014205698855 no 645 0.201320975212805 1090 97690 SGTC_1463 k081-0032 34.1 µM 0.836684808839467 0.197076678091221 no 646 0.201384880149087 858 977755 SGTC_1352 1496-0991 99 µM 0.835039885581278 0.1975290535208 no 647 0.201847625780832 1009 3000039 SGTC_363 0455-0021 3.06 µM 0.834687662252398 0.197626001090306 no 648 0.201946795045687 986 4597466 SGTC_1699 st031318 29.054 µM 0.834148914259847 0.197774344194004 no 649 0.202098537156194 1029 5340658 SGTC_1821 st053465 65.6 µM 0.833933308808296 0.197833729538645 no 650 0.202159283038718 955 675086 SGTC_2752 diclazuril 33.15 µM 0.833556353922178 0.197937582087154 no 651 0.202265514653756 1114 456389 An antifungal agent for coccidioides. YHR062C RPP1 SGTC_3331 9141060 1.957 µM 0.8324596673417 0.19823991074906 no 652 0.202574767431054 959 4906567 YPR165W RHO1 SGTC_1515 3460-0031 42.1 µM 0.831760877897258 0.198432694571833 no 653 0.202771965210269 936 2876596 SGTC_3253 9135987 49.47 µM 0.83169077841798 0.19845204003667 no 654 0.202791753550873 941 4182430 SGTC_2383 9036125 200 µM 0.830551130187295 0.198766710174615 no 655 0.203113626002437 977 79580 SGTC_2926 9010726 65.15 µM 0.830181900608212 0.198868723241395 no 656 0.203217973411738 986 2994293 SGTC_1229 0139-0193 12.2 µM 0.829889068501945 0.198949651169741 no 657 0.203300752994129 1055 3090752 SGTC_257 daunorubicin 18.5 µM 0.829382859517273 0.19908959535055 no 658 0.203443898715832 1011 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_2656 pseudo-anisatin 100 µM 0.828758007355942 0.199262420833513 no 659 0.203620677235864 1010 6708809 A neurotoxin. SGTC_1606 st000094 49.2 µM 0.82607849678058 0.200004560337994 no 660 0.204379782401702 1061 1242210 SGTC_1546 5-methoxyflavanone 78.7 µM 0.821879587088362 0.201170862216708 no 661 0.205572715895652 1045 147795 SGTC_2374 9071832 200 µM 0.82068141190704 0.20150441743618 no 662 0.205913880685088 998 17381698 SGTC_1803 st050068 52.4 µM 0.820215841894527 0.20163411496872 no 663 0.206046536242814 1106 3984059 YIL048W | YNL267W NEO1 | PIK1 SGTC_628 1636-0253 16 µM 0.819250227420384 0.201903273217114 no 664 0.206321831721685 1022 4456143 SGTC_3200 9114385 49.47 µM 0.818907955204518 0.201998730802131 no 665 0.206419465405952 985 17018030 YLR208W SEC13 SGTC_1567 st069303 68.4 µM 0.818010772972636 0.202249077499018 no 666 0.206675517928304 1011 5581319 SGTC_1165 k072-0275 30.3 µM 0.817880954902553 0.20228531685876 no 667 0.206712583099904 1029 6153523 YGL055W OLE1 SGTC_229 benomyl 22.8748 µM 0.817689330196879 0.202338816945544 no 668 0.206767302264036 1010 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C SGTC_384 k007-0144 5.16 µM 0.816508075774452 0.202668800569887 no 669 0.207104803281467 1023 6824886 SGTC_1425 4048-4433 7.33 µM 0.816121519316353 0.202776854986152 no 670 0.207215318636736 1083 23734946 SGTC_1703 st026983 48.3 µM 0.815383889650202 0.202983140642353 no 671 0.207426301542118 1047 1104023 SGTC_214 4373-3496 70 µM 0.815256667035348 0.203018732411083 no 672 0.207462703636584 1144 3779166 SGTC_3053 9095903 49.47 µM 0.814923159013096 0.203112052224504 no 673 0.207558147914691 1063 17174018 SGTC_2883 9059145 45.46 µM 0.807498170208071 0.205196283829204 no 674 0.209689764148265 1013 16476510 SGTC_1945 st075991 56.6 µM 0.806602517417355 0.205448554140448 no 675 0.209947761457083 971 1084980 SGTC_1334 1486-0610 236 µM 0.804367271099974 0.20607893830882 no 676 0.210592448598039 1038 3742339 SGTC_1487 3970-0795 2.82 µM 0.802132962037657 0.206710202953965 no 677 0.211238024850747 1052 3765103 SGTC_2111 5486399 200 µM 0.801893774872327 0.206777848851711 no 678 0.211307203695785 1068 689674 SGTC_2563 tomatine 8.54 µM 0.801889379487216 0.206779092058468 no 679 0.211308475074061 1036 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties. SGTC_1517 deoxycholic acid methyl ester 49.2 µM 0.800096212014281 0.207286647145531 no 680 0.211827527848242 1037 229346 A bile salt which induces apoptosis. SGTC_347 4534-1311 26.2 µM 0.799760499043835 0.207381752326829 no 681 0.211924786633802 1051 2862016 SGTC_2589 lobaric acid 100 µM 0.798799337706824 0.207654185358512 no 682 0.212203387323888 1032 73157 A novel microtubule depolymerizer. SGTC_3096 9117468 49.47 µM 0.79831368209522 0.207791920698839 no 683 0.212344240066796 954 41316311 SGTC_1231 0242-0792 125 µM 0.796215106470497 0.208387711522001 no 684 0.212953509301043 1036 3707635 SGTC_500 h-89 112 µM 0.794375973874503 0.208910673309811 no 685 0.213488293469003 1076 449241 Protein kinase A inhibitor; also known to inhibit several other kinases. SGTC_1925 st057770 10.1 µM 0.793253948651213 0.20923010325601 no 686 0.21381494074352 991 5989122 SGTC_1968 st069590 43.6 µM 0.792349275109996 0.209487864477614 no 687 0.214078523769356 1031 6384066 SGTC_1218 1348-1416 30.7 µM 0.792315165786037 0.209497586621092 no 688 0.214088465459788 1072 6787668 SGTC_599 1935-0052 86.5 µM 0.790713002387218 0.209954548490264 no 689 0.214555743414813 1085 9557311 SGTC_308 4092-1169 104 µM 0.789942632657762 0.21017447826744 no 690 0.214780636023979 1062 2268590 YDL196W YDL196W SGTC_1740 st038286 13.222 µM 0.787946235096951 0.210745051162354 no 691 0.215364077623392 1047 716786 SGTC_1393 3470-5649 58.2 µM 0.786011967562056 0.21129873287457 no 692 0.215930237979838 961 4108395 SGTC_2247 cerulenin 830 nM 0.784983289949593 0.211593537358622 no 693 0.216231682978083 1097 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12 SGTC_2005 4024620 188 µM 0.784645448734236 0.211690410383126 no 694 0.216330737524851 1056 236743 SGTC_2872 9044037 25.97 µM 0.783888187122027 0.211907642827704 no 695 0.216552860911068 1077 6465195 SGTC_2532 xanthone 78.9 µM 0.783427949023839 0.212039733076871 no 696 0.216687924465319 971 7020 An insecticide. SGTC_1461 k072-0203 53.8 µM 0.782324625677705 0.212356587473567 no 697 0.217011909049293 1028 5418714 SGTC_1597 7-benzyloxygramine 47.5 µM 0.781329162558679 0.212642703663991 no 698 0.217304461181246 1098 260807 SGTC_1389 3405-0187 19 µM 0.780271718387861 0.212946880896009 no 699 0.217615477972117 1013 799890 SGTC_48 0382-0018 55 µM 0.778930328830485 0.213333101034314 no 700 0.218010378497278 1124 762596 SGTC_1563 conessine 56.1 µM 0.77887903182695 0.213347878847953 no 701 0.218025488357961 1169 441082 An anti-amoebic, histamine inhibitor. SGTC_2633 5,7-dihydroxyisoflavone 100 µM 0.77763801747055 0.213705576274322 no 702 0.218391221017999 1046 5377381 SGTC_2401 5128683 200 µM 0.774980106725494 0.214472839777827 no 703 0.219175707333839 1051 708373 SGTC_558 k064-0027 21.3 µM 0.774121092157533 0.214721154994193 no 704 0.219429592742951 1071 5088526 SGTC_3020 9089140 49.47 µM 0.773767299553048 0.214823474323498 no 705 0.219534206758443 1103 17217859 SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM 0.77321433143801 0.214983453343412 no 706 0.219697772955366 1027 521171 SGTC_3259 9138485 49.47 µM 0.772471814733053 0.215198379389199 no 707 0.219917517040183 1182 17646153 SGTC_2387 9077560 195.08 µM 0.772410232971804 0.215216210209246 no 708 0.219935747515144 1059 5303272 SGTC_309 k408-0051 1.48 µM 0.771695723660979 0.215423156988861 no 709 0.220147332044805 1086 3640463 SGTC_2108 5365811 200 µM 0.771458827250337 0.215491795913304 no 710 0.220217508908488 1093 780283 SGTC_542 3381-0244 89.3 µM 0.771363545517097 0.215519406643967 no 711 0.220245738251612 1116 1112843 SGTC_3274 9138298 49.47 µM 0.770505024233574 0.215768281369324 no 712 0.220500187930257 1101 17015756 SGTC_107 0358-0022 2.6945 µM 0.769696225985186 0.216002894318897 no 713 0.220740054658788 1019 521106 YGL093W | YPR107C SPC105 | YTH1 SGTC_3220 9131269 49.47 µM 0.766951486075347 0.216800178354724 no 714 0.221555180219229 1109 17722206 SGTC_2018 5133068 143 µM 0.766787197239638 0.216847954407451 no 715 0.221604024790651 1044 785362 SGTC_1709 st033179 39.1045 µM 0.76636020541116 0.216972154328916 no 716 0.221731002140115 1096 573381 SGTC_3037 9091026 49.47 µM 0.765664684741514 0.21717454974594 no 717 0.221937922638868 1144 25236398 YIL048W NEO1 SGTC_3280 9140961 49.47 µM 0.765229420660071 0.217301266371607 no 718 0.222067471718022 1060 4901226 SGTC_2823 7987624 58.44 µM 0.765013824443005 0.217364047813087 no 719 0.222131656311836 1065 2239440 SGTC_2054 5233173 129 µM 0.764383573647208 0.217547636376334 no 720 0.222319347357803 1079 6889 SGTC_1257 0669-0121 16 µM 0.763637276523319 0.217765144279482 no 721 0.222541714387277 1162 4307855 SGTC_2042 p-Dimethylaminoacetophenone 200 µM 0.763182384096077 0.217897783951342 no 722 0.222677316525779 1080 75037 A free radical scavenger. SGTC_2623 humulene 100 µM 0.762442869069418 0.218113514624327 no 723 0.222897864338166 998 6187145 An anti-inflammatory. SGTC_1673 st016611 27.3 µM 0.761369733182389 0.218426787716461 no 724 0.223218130119451 1095 5226799 SGTC_2575 plumbagin 510 nM 0.760929983532485 0.218555235588085 no 725 0.223349444263344 1044 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_2838 9002687 71.43 µM 0.760636921297674 0.218640861210626 no 726 0.223436980314919 1037 6457060 SGTC_1278 0874-0585 172 µM 0.759680571967615 0.218920417403985 no 727 0.223722772249611 1101 766306 SGTC_2157 5649910 96.377 µM 0.757918412493504 0.219436062906632 no 728 0.224249913419407 1089 2858091 SGTC_2596 sinensetin 100 µM 0.755331554124349 0.220194295560153 no 729 0.225025035157523 1069 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets. SGTC_640 3381-0960 37.1 µM 0.755136412551658 0.220251554281873 no 730 0.225083568560964 1140 1745025 SGTC_274 sirtinol 40.1 µM 0.755019646359606 0.220285820068635 no 731 0.22511859711744 1130 6836442 NAD-dependent acetyltransferase inhibitor. SGTC_709 3807-1509 243 µM 0.754719322597076 0.220373966038719 no 732 0.225208705085554 1118 1886677 YPL242C IQG1 SGTC_145 3737-0113 38.366 µM 0.753941523157937 0.220602346586907 no 733 0.225442167935395 1179 6849351 SGTC_1660 st012960 28.1 µM 0.753744241307462 0.2206602948146 no 734 0.225501405468128 1072 24207266 SGTC_1339 1486-1321 22.7 µM 0.752643224685516 0.220983860021583 no 735 0.225832167863539 1090 3469382 SGTC_1993 st073995 70.8 µM 0.752108241627049 0.221141178069235 no 736 0.225992984034872 1108 3098394 SGTC_2489 cantharidin 73.42 µM 0.751359292255658 0.221361523029953 no 737 0.22621822730411 1126 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_227 fluconazole 33.516 µM 0.751006726626668 0.221465293193445 no 738 0.226324303778888 1122 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C SGTC_963 1269-2853 151 µM 0.749973493715806 0.221769563358963 no 739 0.226635334490566 1085 3668223 SGTC_2706 st078239 82.5 µM 0.749682036244044 0.221855435973318 no 740 0.226723114582129 1136 15434492 SGTC_1886 st057356 49.9 µM 0.749490741890618 0.221911807677854 no 741 0.22678073834013 1081 24207747 SGTC_1720 st037298 9.481 µM 0.748829267183149 0.222106797827585 no 742 0.226980058594639 1083 597396 SGTC_2282 7944268 200 µM 0.74778532852394 0.222414729943529 no 743 0.227294826497829 1121 2970414 SGTC_445 e6 berbamine 66 µM 0.744857482895601 0.22327965877783 no 744 0.228178940166979 1166 6610268 A calcium/calmodulin antagonist. SGTC_658 3253-0951 102 µM 0.743102876246339 0.223798911535995 no 745 0.228709699208088 1148 1184878 SGTC_235 0330-0087 5 mM 0.741840313382002 0.224172974679485 no 746 0.229092046124979 1156 46494818 YHR062C RPP1 SGTC_3337 9144342 33.5465 µM 0.739883240854173 0.224753503346794 no 747 0.229685422168704 1130 17682949 SGTC_3225 9130819 49.47 µM 0.738999922509906 0.225015802048907 no 748 0.22995352220674 1114 4547121 SGTC_1208 2323-2347 50.3 µM 0.738164628654124 0.22526399953174 no 749 0.230207207158744 1130 5412760 SGTC_2317 5986382 200 µM 0.735839047662265 0.225955833991627 no 750 0.2309143273724 1175 877883 SGTC_603 3794-0023 45.9 µM 0.734047015303381 0.22648976216445 no 751 0.231460042134927 1130 3802260 SGTC_2895 9054447 58.44 µM 0.733898900258652 0.226533924241251 no 752 0.231505178697406 1162 2697450 SGTC_642 0335-0876 158 µM 0.733403497728415 0.226681669094749 no 753 0.231656183259014 1148 6812350 SGTC_1625 st003711 30.1 µM 0.73180967846894 0.227157365616359 no 754 0.232142370430457 1161 24207034 YER133W GLC7 SGTC_2490 carminic acid 95.39 µM 0.730260577745308 0.227620254045821 no 755 0.23261546017451 1111 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_2991 9074669 71.4286 µM 0.72973895938286 0.227776238818296 no 756 0.232774881069739 1146 17333109 SGTC_359 0081-0058 15.9 µM 0.728331502345016 0.228197424838988 no 757 0.233205341360593 1162 3494159 SGTC_3325 9138760 55.175 µM 0.726769249570313 0.228665446290843 no 758 0.23368366175496 1133 43844959 SGTC_1921 5740136 50 µM 0.724774276492741 0.229263885450887 no 759 0.234295259566986 1153 1774243 SGTC_2186 6124449 200 µM 0.724753044297821 0.229270259266937 no 760 0.234301773470816 1117 3834182 YLR033W RSC58 SGTC_2114 5491910 81.25 µM 0.724231968591063 0.229426715148817 no 761 0.234461667632543 1164 2849228 SGTC_1211 1056-0033 32.3 µM 0.722833658146555 0.229846861246456 no 762 0.234891043001994 1147 6741922 SGTC_2231 micatex 6.853 µM 0.722231685039354 0.230027866832821 no 763 0.235076022963071 1138 20737 An antifungal of unknown mechanism. SGTC_1969 st069479 40.1 µM 0.721019066550232 0.230392727717115 no 764 0.235448891976285 1125 3895485 SGTC_3210 9128157 49.47 µM 0.720120643053957 0.230663260012128 no 765 0.235725359276118 1087 17590849 SGTC_128 0906-2981 13.371 µM 0.719592735956289 0.230822305561623 no 766 0.235887892908901 1109 6740226 SGTC_1642 st009582 77.7 µM 0.71876816390388 0.231070851531728 no 767 0.236141888198189 1161 6739311 SGTC_3221 9128209 49.47 µM 0.718398078257519 0.231182452847247 no 768 0.236255935702786 1164 16460723 SGTC_1496 4469-0713 57.4 µM 0.717716539531546 0.231388053179587 no 769 0.236466041538242 1148 746691 SGTC_2611 pyromycin 23.93 µM 0.716681216980245 0.2317005747746 no 770 0.236785409087176 1154 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release. SGTC_3298 9116858 71.43 µM 0.7152523284174 0.23213228392679 no 771 0.23722656987525 1175 2506942 SGTC_2865 9030313 51.95 µM 0.714307117193071 0.232418105826072 no 772 0.237518646109048 1122 42562754 SGTC_2253 7938677 135.83 µM 0.712603981921836 0.23293360971445 no 773 0.238045423528587 1181 2301972 SGTC_937 3122-0005 46.7 µM 0.710895852459752 0.233451262512944 no 774 0.23857438817754 1174 759535 SGTC_52 0329-0193 875 nM 0.710268939660078 0.233641409927768 no 775 0.238768688544182 1228 3739292 SGTC_804 1595-0054 20.9 µM 0.710182788681835 0.2336675468833 no 776 0.238795396257062 1133 761523 Stimulates phospholipase C. SGTC_1005 4092-0690 4.4 µM 0.709480249225778 0.233880747647901 no 777 0.239013251894268 1154 1529343 SGTC_876 0720-0963 56.8 µM 0.709218458301067 0.233960221313269 no 778 0.239094460351954 1192 765861 SGTC_216 k038-0035 28.382 µM 0.708951672039147 0.234041226836677 no 779 0.239177233894111 1130 4444231 YPR107C YTH1 SGTC_1421 4029-0249 71.4 µM 0.708230482181704 0.234260282722543 no 780 0.239401069801367 1245 2894095 SGTC_432 NS 1619 61.3 µM 0.707799344855658 0.234391291563546 no 781 0.239534936640134 1156 4552 A K+/calcium channel activator. SGTC_930 2810-3379 265 µM 0.7076271221486 0.234443635864939 no 782 0.239588422691806 1218 1015764 SGTC_2045 5106652 78.05 µM 0.706245958514953 0.234863652008512 no 783 0.240017597119065 1164 673349 SGTC_444 curcumin 90.4 µM 0.704565845234357 0.23537513983799 no 784 0.240540229944847 1134 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. SGTC_2432 5630864 12.22 µM 0.704450985473815 0.235410129782065 no 785 0.240575981984599 1151 5714970 SGTC_2663 amphotericin b 100 µM 0.704200604803645 0.235486413663401 no 786 0.24065392722181 1172 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_293 4049-0273 38.5 µM 0.703779182190565 0.235614839962632 no 787 0.240785150034646 1116 1380311 SGTC_1505 k297-0037 20.6 µM 0.702532961398926 0.235994845074082 no 788 0.241173426679372 1192 4089396 SGTC_1654 st012436 41.8 µM 0.702181983918967 0.236101928151707 no 789 0.241282839767267 1158 4323132 SGTC_1826 st055655 41.6 µM 0.701879938828905 0.236194103404654 no 790 0.241377020350785 1185 676168 SGTC_866 0495-0101 262 µM 0.701146365372786 0.23641805088816 no 791 0.241605838788658 1163 635694 SGTC_2254 7938975 95.19 µM 0.700742646363974 0.236541349271873 no 792 0.241731818261083 1211 2969277 SGTC_2409 alverine citrate 63.97 µM 0.700270826202016 0.236685491016374 no 793 0.241879093692755 1202 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_565 1418-0001 44.5 µM 0.700189594983982 0.236710312145753 no 794 0.241904454372285 1207 2862145 SGTC_409 arachidonic acid 100 µM 0.699170781689748 0.237021743777562 no 795 0.242222654034285 1220 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes. SGTC_2462 5162487 171.77 µM 0.697936895244255 0.237399220453568 no 796 0.242608329741825 1176 2259986 SGTC_2125 5246583 200 µM 0.697289429369668 0.237597428395176 no 797 0.242810841000736 1230 835267 SGTC_3005 9076496 71.4286 µM 0.697139119391933 0.23764345559075 no 798 0.242857867312702 1199 21368410 SGTC_2214 7179297 48.276 µM 0.694484315446765 0.238457202595046 no 799 0.243689266816159 1199 769744 SGTC_2753 fluvastatin 17.09 µM 0.693864787996332 0.23864731864617 no 800 0.243883503865137 1189 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5 SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM 0.693510544682947 0.238756063505542 no 801 0.243994605362908 1149 6857784 SGTC_2702 st077768 96.8 µM 0.692794020241399 0.238976103503101 no 802 0.244219412703518 1139 6484119 SGTC_1311 1190-0148 100 µM 0.691884863257244 0.239255459227243 no 803 0.244504818574721 1251 1961333 SGTC_2176 5809774 33.9695 µM 0.690284542359643 0.239747621303114 no 804 0.24500763333223 1200 2870539 SGTC_687 k029-0044 34.9 µM 0.689994801113888 0.239836787239587 no 805 0.245098728371616 1227 5829338 SGTC_3186 9110464 49.47 µM 0.689720261323583 0.239921291718458 no 806 0.245185060858149 1210 17018021 SGTC_2603 homopterocarpin 100 µM 0.689200819892865 0.240081222350142 no 807 0.245348450469913 1222 101795 A weak amylase inhibitor. SGTC_595 3909-8003 73.7 µM 0.688342076189174 0.240345748049443 no 808 0.245618695457328 1240 699517 SGTC_2654 protoveratrine a 100 µM 0.688087979418565 0.24042404994329 no 809 0.245698689861489 1189 5702278 A heart drug and vasodilator. SGTC_471 1-acyl-paf 4 µM 0.688054082639955 0.240434496549236 no 810 0.245709362257314 1161 16759367 SGTC_488 nitrendipine 139 µM 0.686767597271455 0.24083115955912 no 811 0.246114595924817 1233 4507 Dihydropyridine L-type calcium channel blocker. SGTC_1610 st001799 48.1 µM 0.686420109653924 0.240938361720421 no 812 0.24622411348854 1134 621897 SGTC_2388 9080168 200 µM 0.685013208545711 0.241372664907658 no 813 0.246667793019141 1185 15943073 SGTC_2915 7971052 15.16 µM 0.682740938881513 0.242075000199389 no 814 0.247385277909966 1104 5741558 SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM 0.68248450861606 0.242154329697567 no 815 0.247466317528929 1288 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W SGTC_1004 4084-0029 199 µM 0.682246223528715 0.242228058418666 no 816 0.24754163544396 1227 716894 YLR208W SEC13 SGTC_1989 st071868 50.2 µM 0.681332188413476 0.242510986421608 no 817 0.247830660151447 1215 16414057 SGTC_3203 9113543 49.47 µM 0.680340490222098 0.242818156383421 no 818 0.248144446144505 1242 17018012 SGTC_1986 st071812 45 µM 0.678087593724011 0.243516753442535 no 819 0.248858078195844 1186 11838594 SGTC_2712 st079126 47.7 µM 0.677227256895809 0.243783820087873 no 820 0.249130888208982 1200 3152970 SGTC_2878 9043973 25.97 µM 0.677199560783906 0.243792420169344 no 821 0.249139673198294 1256 6465167 SGTC_1070 indatraline 8.81 µM 0.676936275622433 0.243874182559549 no 822 0.249223193412699 1210 10314472 A monamine transport inhibitor. YGL099W LSG1 SGTC_4 0960-0234 25.671 µM 0.676757385672326 0.243929744720349 no 823 0.249279949985101 1215 6821112 SGTC_287 k060-0039 29.6 µM 0.673564044607086 0.244922725784591 no 824 0.250294259362479 1261 5861974 SGTC_1796 st049173 110.4 µM 0.673056770314464 0.245080664544427 no 825 0.250455587413664 1184 94134 SGTC_231 b-estradiol 524 µM 0.67260945171233 0.245219981667641 no 826 0.250597893512299 1177 450 A steroid. SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM 0.671139563739245 0.245678077132211 no 827 0.251065812514364 1243 688761 SGTC_2161 5662504 8.5105 µM 0.670808876328678 0.245781200247287 no 828 0.251171146046526 1207 2859334 SGTC_1706 st031321 9.9705 µM 0.669802332276491 0.246095228630413 no 829 0.251491903311689 1250 6103185 SGTC_40 0327-0103 19.753 µM 0.668743998787415 0.246425646596799 no 830 0.251829397714462 1174 409036 SGTC_2394 5221648 200 µM 0.667815702979217 0.2467156616365 no 831 0.25212562082085 1302 788586 SGTC_1402 3909-7673 35.9 µM 0.665683604849024 0.24738245589059 no 832 0.252806677561725 1234 5328014 SGTC_2720 fluspirilene 36.88 µM 0.665679016505423 0.24738389189117 no 833 0.25280814426139 1218 3396 An atypical antipsychotic. SGTC_750 4073-0104 132 µM 0.664039656979354 0.247897242531883 no 834 0.253332464870751 1122 22330957 SGTC_34 0469-0683 81.75 µM 0.663506170634251 0.248064421501856 no 835 0.253503214392078 1249 3690923 SGTC_2521 angolensin 13.4 µM 0.662999425177006 0.248223276345707 no 836 0.253665461112886 1264 821428 A flavenoid. SGTC_1949 st076024 69.1 µM 0.662983596757508 0.248228239120852 no 837 0.253670529839483 1231 2921930 SGTC_1748 st037455 53.6035 µM 0.662978049178389 0.248229978497673 no 838 0.253672306350466 1241 580690 SGTC_1181 1222-0449 220 µM 0.662750416884715 0.248301355474393 no 839 0.253745207072973 1300 658318 SGTC_2692 st077426 47.7 µM 0.661212183022902 0.248783974770923 no 840 0.254238124655648 1229 25238571 SGTC_2180 6301957 200 µM 0.660144638425323 0.249119209152925 no 841 0.254580507651251 1224 845462 SGTC_1855 st056195 39.6 µM 0.658838883427489 0.249529573733688 no 842 0.254999617657477 1221 4028379 SGTC_1632 st005650 90 µM 0.658803925573542 0.249540565005562 no 843 0.255010843088239 1255 2759605 SGTC_1216 1165-0504 9.65 µM 0.658289049323673 0.249702479585754 no 844 0.255176206624893 1252 6304004 SGTC_1644 st010134 20.9 µM 0.657993120640199 0.249795566353128 no 845 0.255271275831022 1243 3818134 SGTC_327 1273-0057 3.96 µM 0.65696729371535 0.250118391110536 no 846 0.255600973359164 1199 3108138 SGTC_1845 st056753 3.01 µM 0.655238570923021 0.250662915482844 no 847 0.256157082188596 1217 5375839 SGTC_1813 st051246 8.6015 µM 0.652077611911177 0.25166019633562 no 848 0.257175552945591 1218 5291959 SGTC_2795 7780010 54.55 µM 0.652035323000686 0.251673552655286 no 849 0.257189192821253 1257 953673 SGTC_3022 9087993 49.47 µM 0.649458323434945 0.252488165438753 no 850 0.258021088157761 1284 17173644 SGTC_3353 9151644 39.2805 µM 0.648943197019403 0.25265116800494 no 851 0.258187546150957 1271 4909158 SGTC_1938 st074717 56.4 µM 0.647537725170249 0.253096186258346 no 852 0.258641993440578 1188 17250979 SGTC_2354 9060492 162 µM 0.646472593604735 0.253433716120035 no 853 0.258986670254719 1277 6471895 SGTC_3307 9126885 69.2785 µM 0.645829760131101 0.253637538220742 no 854 0.259194806208955 1258 24824909 SGTC_2244 6635614 200 µM 0.645623780626349 0.253702865995957 no 855 0.259261516325057 1223 836499 SGTC_1065 prochlorperazine maleate 2.48 µM 0.645510617304034 0.253738760259496 no 856 0.259298170050331 1308 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine. SGTC_265 mycophenolic acid 32.932 µM 0.644979017918012 0.253907413897662 no 857 0.259470391508215 1356 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1 SGTC_2422 chlorphenesin carbamate 384.24 µM 0.644770148603805 0.25397369524986 no 858 0.259538074750292 1280 2724 A muscle relaxant with antifungal properties. SGTC_2179 6298986 200 µM 0.643112410355321 0.2545000739078 no 859 0.260075581149509 1252 738374 SGTC_961 1252-1571 372 µM 0.642978322957289 0.254542675412321 no 860 0.260119082831597 1302 6813498 SGTC_637 1181-0519 7.26 µM 0.642483938618171 0.254699780737441 no 861 0.260279507268994 1286 6252091 YGR060W ERG25 SGTC_936 3005-4620 401 µM 0.642289719865348 0.254761513410494 no 862 0.260342543910111 1322 777207 SGTC_1818 st052136 56.3 µM 0.641094446237724 0.255141605010591 no 863 0.260730661159181 1189 674169 SGTC_2533 agelasine 13.65 µM 0.640686528442471 0.255271388866323 no 864 0.260863184240145 1322 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase. SGTC_1992 st073643 23.3 µM 0.639397902751506 0.255681606938085 no 865 0.261282056490088 1265 3161292 SGTC_75 0159-0059 199.013 µM 0.639384193426934 0.255685972982029 no 866 0.261286514610468 1394 5377270 SGTC_2437 5741531 144.16 µM 0.639245455378319 0.255730159436495 no 867 0.261331632884642 1371 2262990 SGTC_1302 1159-0335 255 µM 0.63783042438786 0.256181057941537 no 868 0.261792036154148 1287 649284 SGTC_3110 9122132 49.47 µM 0.63743464163439 0.256307247950879 no 869 0.26192088491212 1354 918317 SGTC_1695 st026914 34.495 µM 0.636375116570144 0.256645222667541 no 870 0.262265977779142 1266 3289191 SGTC_877 0771-0151 33.1 µM 0.635516435943995 0.256919300776722 no 871 0.262545825328668 1326 6166523 SGTC_3152 9099253 49.47 µM 0.63505563446972 0.257066444535126 no 872 0.26269606541604 1291 25236131 SGTC_1418 3966-3099 2.4 µM 0.634749331497156 0.25716427786523 no 873 0.262795957016392 1305 740335 SGTC_2126 5251174 33.877 µM 0.634583374757265 0.257217292619912 no 874 0.262850086982113 1342 790722 SGTC_971 1315-0384 26.7 µM 0.633004195399901 0.25772204438706 no 875 0.263365451638441 1283 6769120 SGTC_3052 9092717 49.47 µM 0.631862427999372 0.25808730655464 no 876 0.263738388144274 1288 25237534 SGTC_1947 st076332 61.6 µM 0.631113945701921 0.258326898696089 no 877 0.263983011655701 1285 24208416 SGTC_203 k066-0004 30.888 µM 0.630269210726831 0.258597440081278 no 878 0.264259231878069 1364 6795412 SGTC_2968 9090663 33.37 µM 0.629825528469962 0.258739595949513 no 879 0.264404370643309 1284 25236811 SGTC_1057 3448-5381 134 µM 0.629397951610696 0.258876629907143 no 880 0.264544279341008 1310 5497911 SGTC_2834 9001755 58.44 µM 0.629357645572174 0.258889549511666 no 881 0.264557469942358 1291 2989575 SGTC_2944 9067346 25.62 µM 0.625956035703197 0.259981094474645 no 882 0.26567188920689 1284 6473075 SGTC_1412 3909-8563 178 µM 0.625705875498573 0.260061462146129 no 883 0.265753939369866 1367 23767530 SGTC_2824 7998404 51.95 µM 0.624991476318982 0.260291043967711 no 884 0.265988326195569 1298 837851 SGTC_1548 st061468 90.8 µM 0.624399805228257 0.260481264488245 no 885 0.266182526481187 1294 390799 SGTC_1319 1306-0155 43.7 µM 0.621556410004531 0.26139640531563 no 886 0.267116795586271 1332 3122360 SGTC_3184 9108758 49.47 µM 0.620167953053047 0.261843876545191 no 887 0.267573608896483 1314 902885 SGTC_1168 k815-0004 80.5 µM 0.620016605442998 0.261892676515137 no 888 0.267623427251625 1285 642433 SGTC_2417 cerulenin 830 nM 0.619660287387437 0.262007584819168 no 889 0.267740733187688 1382 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1 SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM 0.619474033407513 0.262067659780761 no 890 0.267802061460592 1271 4620898 SGTC_798 1287-0182 476 µM 0.617871374682031 0.262584878097446 no 891 0.268330064835694 1342 1649755 SGTC_776 4476-4378 112 µM 0.61733873572953 0.262756889684245 no 892 0.268505661074976 1306 2892008 SGTC_964 1287-0107 19.4 µM 0.617141902266577 0.262820470094669 no 893 0.268570566204997 1364 51516812 YPR165W RHO1 SGTC_1917 st066507 28.5 µM 0.61708529694124 0.262838755992124 no 894 0.268589233068323 1322 3156428 SGTC_2080 5212524 12.4 µM 0.61438630908991 0.263711396852152 no 895 0.269480040341948 1300 260183 SGTC_712 r015-0009 80.6 µM 0.613776021085604 0.263908920749432 no 896 0.26968167241225 1306 6813872 YLR060W FRS1 SGTC_1056 3448-1962 115 µM 0.613597503752606 0.263966713361822 no 897 0.269740666748582 1336 715507 SGTC_15 0266-0086 27.098 µM 0.613247855848232 0.264079925906757 no 898 0.269856233053315 1399 1712902 YIL048W NEO1 SGTC_1927 st060202 13.8 µM 0.611284523412447 0.264716092731326 no 899 0.270505617528986 1285 688887 SGTC_70 0141-0289 43.283 µM 0.609700797123158 0.265229825321107 no 900 0.271030013210834 1395 352408 SGTC_1249 0481-0015 10.2 µM 0.609498832447494 0.265295375438315 no 901 0.27109692320247 1280 4227577 SGTC_87 0100-0052 35.5 µM 0.608458003218843 0.265633319703136 no 902 0.271441875828373 1382 200187 YGR083C | YDR527W GCD2 | RBA50 SGTC_770 0389-1121 67.2 µM 0.607319331151971 0.266003282209676 no 903 0.27181950592105 1420 6753108 SGTC_3121 9125696 49.47 µM 0.606426538625046 0.266293539180423 no 904 0.272115775057945 1380 1235365 SGTC_2144 5628481 200 µM 0.605971574389654 0.266441514843152 no 905 0.272266814593229 1315 2818399 SGTC_1775 st081588 35.1725 µM 0.605353274539212 0.266642681550217 no 906 0.272472145222405 1335 1426443 YGL099W LSG1 SGTC_401 neomycin 50 µM 0.605348457038662 0.266644249247661 no 907 0.272473745363592 1321 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis. SGTC_1698 5-fluorocytosine 1.055 µM 0.604194842743449 0.267019789272868 no 908 0.272857054656148 1365 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_1186 1319-0216 26 µM 0.600957416367652 0.268075104391512 no 909 0.273934174727046 1408 4565136 SGTC_2800 7887935 81.82 µM 0.600916830523218 0.268088347613203 no 910 0.273947691320834 1356 2961002 SGTC_2962 9082311 13.18 µM 0.60027525615859 0.268297738025851 no 911 0.274161403200799 1306 16459453 SGTC_819 1013-0258 27.7 µM 0.599131291503457 0.268671297401499 no 912 0.274542668211378 1332 5753198 SGTC_1620 st003704 16.5 µM 0.597514261479886 0.26919978074431 no 913 0.275082044122617 1311 2834414 SGTC_2517 totarol 10 µM 0.597419412130915 0.269230795920115 no 914 0.27511369823232 1287 460178 An antibacterial membrane disruptor. YGL001C ERG26 SGTC_91 0417-1751 58.384 µM 0.597033390257071 0.269357041277118 no 915 0.275242543964158 1394 6795624 SGTC_3284 9108171 64.8615 µM 0.595329598774017 0.269914606995609 no 916 0.275811587265742 1342 8687505 SGTC_2537 larixol 68.93 µM 0.595137660375767 0.269977455018617 no 917 0.275875728305636 1327 6708759 SGTC_490 phenamil 164 µM 0.592709106586506 0.270773289048453 no 918 0.276687922953639 1359 4755 Irreversibly blocks amiloride-sensitive Na+ channels. SGTC_56 0957-0365 83.25 µM 0.592355958669927 0.270889112635205 no 919 0.276806125666791 1299 6752360 SGTC_112 phenothiazine 287.218 µM 0.592083277835359 0.270978561966334 no 920 0.276897412031804 1364 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.  SGTC_2970 9090938 41.86 µM 0.588490757634122 0.272158414756863 no 921 0.278101467838495 1389 17217104 SGTC_1879 gemcitabine 100 µM 0.587231037292482 0.27257273501658 no 922 0.278524275016168 1356 60750 A nucleoside analog which inhibits DNA replication. SGTC_509 pifithrin 175 µM 0.584805437243163 0.273371392363316 no 923 0.279339273973923 1445 4817 A p53 inhibitor. SGTC_2646 retinol 96.75 µM 0.583539060298718 0.273788821803918 no 924 0.279765235112229 1360 445354 A vitamin A analog and teratogen. SGTC_1475 4092-1048 11.7 µM 0.583462610267381 0.273814031727504 no 925 0.279790960084312 1348 2881759 SGTC_1128 3448-9350 235 µM 0.582324733034607 0.274189390201005 no 926 0.280173984464886 1362 619386 SGTC_29 0299-0004 12.984 µM 0.58217677165794 0.274238217785064 no 927 0.280223808862108 1266 16871 A napthoquinone isolated from Swertia calycina. SGTC_998 3996-0085 177 µM 0.581579347981781 0.274435412590748 no 928 0.280425028483583 1417 715391 SGTC_726 3448-4391 34.2 µM 0.581000443663765 0.274626561350097 no 929 0.280620077266506 1468 1356692 SGTC_2547 epiafzelechin trimethyl ether 100 µM 0.580233256611306 0.274879980433069 no 930 0.280878664768137 1254 6708630 An antioxidant. SGTC_2562 3',7'-dimethoxyflavone 64.92 µM 0.579255254766555 0.275203203383058 no 931 0.281208476273573 1419 688664 SGTC_3040 9091894 49.47 µM 0.578128448971878 0.275575836866876 no 932 0.281588700626326 1318 25236966 SGTC_2487 5918373 44.05 µM 0.575620510918229 0.276406098949605 no 933 0.282435857095587 1407 2876279 SGTC_647 0140-0236 81 µM 0.575300618102582 0.276512088795565 no 934 0.282544001782252 1404 990837 SGTC_2836 9010338 19.48 µM 0.574842027376346 0.276664068066362 no 935 0.282699070149102 1250 2994051 SGTC_371 0195-0006 7.36 µM 0.574764475634647 0.276689773149186 no 936 0.282725297621496 1294 3928593 SGTC_2995 9067767 71.4286 µM 0.572627215394474 0.277398643612978 no 937 0.2834485642274 1389 11673567 SGTC_2620 irigenin 100 µM 0.57041137383867 0.278134513542198 no 938 0.284199358534472 1466 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro. SGTC_212 3807-4682 38.772 µM 0.569595601814505 0.278405666945711 no 939 0.284476006106725 1483 3125501 YBL034C STU1 SGTC_1384 3089-0840 101 µM 0.56878688429221 0.278674602603565 no 940 0.284750388244975 1427 1069836 SGTC_3322 9139058 2.11 µM 0.564668047276606 0.28004626400295 no 941 0.286149785794824 1447 4908926 YPR165W RHO1 SGTC_2813 7971799 71.43 µM 0.564512007409329 0.280098292909722 no 942 0.286202865361758 1438 2234054 SGTC_738 1315-0003 72.4 µM 0.564049797092649 0.280252436761902 no 943 0.286360121355492 1439 6251474 SGTC_3108 9121785 49.47 µM 0.563739231307183 0.280356031317168 no 944 0.286465806960977 1406 17140271 SGTC_2154 5570129 200 µM 0.562662845028003 0.280715221899527 no 945 0.286832244617164 1375 673366 SGTC_761 k216-0224 480 µM 0.560179994590047 0.281544598040415 no 946 0.287678335546124 1500 1340404 SGTC_3120 9124077 49.47 µM 0.559550291374348 0.281755133061271 no 947 0.28789310939063 1411 18774327 YGL155W CDC43 SGTC_3015 9080845 49.47 µM 0.559027453455025 0.281929996373264 no 948 0.288071492038106 1478 5296973 SGTC_671 0560-0003 407 µM 0.558499246007834 0.282106708597726 no 949 0.288251759620744 1403 3238678 SGTC_2790 5423970 71.43 µM 0.558183836281418 0.282212254597736 no 950 0.288359428581113 1482 1376240 YKL165C | YIL048W MCD4 | NEO1 SGTC_1087 pterostilbene 9.05 µM 0.55740536639012 0.282472836383705 no 951 0.288625249901715 1497 5281727 Similar to reservatol, lowers cholesterol. SGTC_2719 novobiocin 32.65 µM 0.55649180445917 0.282778785807357 no 952 0.288937347747885 1468 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication. SGTC_2625 euphol 100 µM 0.555173083639199 0.283220702398514 no 953 0.289388138845381 1476 6708538 A triterpene alcohol. SGTC_1779 st039427 55 µM 0.553016872910474 0.283943983137683 no 954 0.290125928215799 1549 1124498 SGTC_2900 5328528 85.29 µM 0.552099595515199 0.284251943039392 no 955 0.290440059521927 1367 795359 SGTC_2486 5283202 22.39 µM 0.551991695661897 0.284288179028299 no 956 0.290477021426708 1351 1377751 SGTC_1524 corynanthine 62.1 µM 0.551738082816762 0.284373358478872 no 957 0.290563907078714 1469 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist. SGTC_436 n,n-dimethylsphingosine 3.3 µM 0.55142502314805 0.284478520799444 no 958 0.290671175485314 1504 5282309 SGTC_1690 st023502 41.2 µM 0.551414932370156 0.284481910780553 no 959 0.290674633350491 1465 24207482 SGTC_2120 5538279 151.968 µM 0.551072060791582 0.284597109419066 no 960 0.29079213856809 1444 2058197 SGTC_2916 7875993 68.79 µM 0.550088769895765 0.284927600827179 no 961 0.291129244441279 1500 1299250 SGTC_2698 st077697 67.5 µM 0.549194669332431 0.285228273511939 no 962 0.291435931136387 1348 3154499 SGTC_1504 k297-0033 30 µM 0.548612156947169 0.285424245040474 no 963 0.291635820578827 1319 4388117 SGTC_406 estrone 100 µM 0.54779100363528 0.285700610107908 no 964 0.291917708286201 1504 5870 A steroid. SGTC_2822 7994718 71.43 µM 0.547471281838545 0.285808249206352 no 965 0.292027497551904 1426 1018011 SGTC_2445 5742597 35.57 µM 0.543239155163009 0.287234871663396 no 966 0.293482575413303 1379 1774255 SGTC_486 niguldipine 82 µM 0.543016514279901 0.287310015680819 no 967 0.293559216064208 1419 1236 A calcium channel blocker. SGTC_2742 clothiapine 36.27 µM 0.541661276735721 0.287767625422421 no 968 0.29402593522186 1454 16351 An atypical antipsychotic. YIL048W NEO1 SGTC_517 1365-0151 113 µM 0.540389071142288 0.288197511659862 no 969 0.294464371577662 1438 768657 SGTC_120 rhodamine 6G 52.259 µM 0.539727591677085 0.288421149356359 no 970 0.294692454417028 1409 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase SGTC_2391 6285546 200 µM 0.537464244819473 0.28918697595639 no 971 0.295473488228106 1387 846083 SGTC_743 1275-0778 158 µM 0.536955248312454 0.289359331720856 no 972 0.295649263349254 1501 2849257 YMR203W TOM40 SGTC_2524 avocatin b 10.57 µM 0.533844784897507 0.290413640224549 no 973 0.296724462943541 1437 6710748 SGTC_2512 diallyl trisulfide 49.23 µM 0.53367190769195 0.29047229061168 no 974 0.296784274208938 1391 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent SGTC_2759 disulfiram 3.38 µM 0.53298170863705 0.290706503042193 no 975 0.297023121106764 1377 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_1173 0443-0020 122 µM 0.532816563956854 0.290762556397664 no 976 0.297080283296465 1428 5331295 SGTC_2425 5628681 7.85 µM 0.532146456471913 0.290990055911973 no 977 0.297312281887572 1478 5714958 SGTC_1000 4048-0884 8.67 µM 0.532066420439145 0.291017233467854 no 978 0.297339996776593 1461 13040088 SGTC_388 3',4'-dichloroisocoumarin 16.7 µM 0.531508333592376 0.291206774022879 no 979 0.297533283971614 1454 1609 A potent and irreversible inhibitor of serine proteases. SGTC_1118 chelidonine 707.474 nM 0.530493716677253 0.291551511415179 no 980 0.29788483215752 1522 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor. SGTC_2033 5192550 145 µM 0.530176964363291 0.291659173628602 no 981 0.297994620439468 1410 182073 SGTC_337 1315-0038 354 µM 0.529976030747482 0.291727479365898 no 982 0.298064274813808 1423 1626437 SGTC_3209 9113616 49.47 µM 0.529594782998301 0.291857101904089 no 983 0.298196456131365 1533 16649353 SGTC_1715 st032160 10.2275 µM 0.528998391201514 0.292059926253938 no 984 0.298403282955722 1454 5289825 SGTC_2049 5262831 67.185 µM 0.527798269649077 0.29246826922208 no 985 0.298819679130416 1456 763417 SGTC_2297 7971671 152.32 µM 0.52775349871285 0.292483507726582 no 986 0.298835218036653 1521 909016 SGTC_1187 1391-0724 117 µM 0.52693368094573 0.292762611047478 no 987 0.299119821796357 1464 6997986 SGTC_853 0419-0306 21 µM 0.525902848644451 0.293113728741895 no 988 0.299477854794038 1381 762713 SGTC_2699 st077704 54.6 µM 0.524811410978996 0.293485702293122 no 989 0.299857149100991 1467 645852 SGTC_1407 3909-7909 12.3 µM 0.524794587253722 0.293491437708103 no 990 0.299862997351053 1429 4411780 SGTC_2669 eugenol 100 µM 0.522170657046938 0.294386602537373 no 991 0.300775757173973 1475 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism. SGTC_2065 5221596 34.26 µM 0.521187922053802 0.294722190885906 no 992 0.301117933538824 1488 788581 SGTC_470 aa-861 153 µM 0.520725090271783 0.29488030165242 no 993 0.301279146670044 1414 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor. SGTC_1316 1272-0050 65.9 µM 0.520719593450541 0.294882179689682 no 994 0.301281061551192 1456 7340392 SGTC_2038 4100038 30.985 µM 0.518846764998788 0.295522368624326 no 995 0.301933801749577 1483 3596803 SGTC_3349 9149703 23.001 µM 0.517625471813069 0.295940187236337 no 996 0.30235980315644 1418 4910494 SGTC_1317 1273-0028 910 nM 0.516799759720878 0.296222826544567 no 997 0.302647973898004 1436 5917803 YLR359W | YHR072W ADE13 | ERG7 SGTC_1157 4092-0394 27.6 µM 0.516527113973731 0.296316179727425 no 998 0.302743153364844 1558 3659885 SGTC_2223 6903751 107.57 µM 0.515388275994678 0.29670626061688 no 999 0.303140861719946 1460 5598863 SGTC_1920 st075728 45.7 µM 0.515147378057916 0.296788804390116 no 1000 0.30322501874024 1560 3400306 SGTC_430 0958-0115 16.4 µM 0.51424680860454 0.29709747793222 no 1001 0.303539722635669 1467 6833180 SGTC_1756 st041558 35.5 µM 0.514052694724041 0.297164030415216 no 1002 0.303607574813384 1620 3955792 SGTC_2439 5492030 7.2 µM 0.513483385645519 0.297359258908307 no 1003 0.303806614879145 1469 5722370 SGTC_1904 st060225 78 µM 0.513418681495244 0.297381451079456 no 1004 0.303829240226239 1415 66595 SGTC_747 3448-8087 38.7 µM 0.513416871096688 0.297382072019201 no 1005 0.303829873286019 1454 5168703 SGTC_3163 9099914 49.47 µM 0.512887843566465 0.297563545950571 no 1006 0.304014888722087 1504 16268368 SGTC_1827 berberine 7.24 µM 0.51130449505442 0.298106988659981 no 1007 0.304568928974165 1350 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_2635 hydroquinidine 100 µM 0.510670543710333 0.298324702470531 no 1008 0.304790885057412 1478 442912 An experimental heart treatment. SGTC_2833 9001315 45.46 µM 0.510421678787459 0.298410188321937 no 1009 0.304878036129182 1500 2989378 SGTC_2690 usnic acid 100 µM 0.508536511837648 0.299058110603344 no 1010 0.305538570094558 1607 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_2256 7954252 200 µM 0.506797783795473 0.299656268173084 no 1011 0.306148355756438 1432 2972920 SGTC_1401 3807-4679 7.6 µM 0.505229720172312 0.300196178086212 no 1012 0.30669874910844 1486 3291456 SGTC_169 k015-0017 16.025 µM 0.504479373849043 0.300454690077048 no 1013 0.306962276484567 1559 1840002 SGTC_1973 st070275 50.2 µM 0.504441549719205 0.300467724043045 no 1014 0.306975563251101 1449 17118334 SGTC_774 k060-0086 136 µM 0.50169258389205 0.301415683938518 no 1015 0.307941890990914 1521 5911235 SGTC_2937 9044753 11.33 µM 0.501156583833101 0.301600676192207 no 1016 0.308130463467136 1429 6465530 YGL099W LSG1 SGTC_3155 9099265 49.47 µM 0.501083556499079 0.301625884416479 no 1017 0.308156159448538 1495 25236499 SGTC_1143 3454-2408 5.08 µM 0.499805178048193 0.302067319853299 no 1018 0.308606132120497 1454 X1143 SGTC_707 0865-0008 204 µM 0.499451973127645 0.302189335780008 no 1019 0.308730506412882 1559 723043 SGTC_2762 leflunomide 42.06 µM 0.498093768442936 0.302658738481693 no 1020 0.30920897628351 1509 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1 SGTC_973 1325-0077 65.9 µM 0.498073982508448 0.302665579018694 no 1021 0.309215948889204 1597 2835149 SGTC_690 glyoxal 20.3 µM 0.497647379743656 0.302813084069696 no 1022 0.309366301326361 1388 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins. SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM 0.497232274971986 0.302956644389788 no 1023 0.309512632039808 1454 16623 A steroid. SGTC_2316 5844804 197.44 µM 0.497108391443952 0.302999494315241 no 1024 0.309556308711472 1549 776813 SGTC_3127 9126946 49.47 µM 0.494750434630834 0.303815601666241 no 1025 0.310388147839701 1430 27243249 SGTC_2465 5809242 33.21 µM 0.494567132810117 0.303879084924429 no 1026 0.310452853707989 1539 2731748 SGTC_934 2950-0684 338 µM 0.492794197392182 0.304493414015255 no 1027 0.311079005579738 1602 1121253 SGTC_2081 5214970 32.255 µM 0.492430618242363 0.304619463876044 no 1028 0.311207479379081 1568 2063512 SGTC_1264 0783-0040 158 µM 0.49221509120588 0.304694196258141 no 1029 0.3112836485599 1425 2855798 SGTC_602 3130-1533 38.1 µM 0.491147009247835 0.30506466589933 no 1030 0.311661237468147 1572 720941 SGTC_1190 1486-1332 13 µM 0.488448820271789 0.306001435962418 no 1031 0.312615984402254 1464 4150046 SGTC_3112 9123419 49.47 µM 0.488266096195246 0.306064920967137 no 1032 0.312680686407808 1514 17015854 SGTC_152 4469-0003 551.229 µM 0.486059840976799 0.306831913814626 no 1033 0.313462369432508 1510 697280 SGTC_508 roscovitine 141 µM 0.485718628633205 0.306950610120648 no 1034 0.313583336976822 1558 160355 A CDKinase inhibitor. SGTC_678 1218-2179 85.9 µM 0.483995842186251 0.307550218473495 no 1035 0.314194409952874 1528 6820081 YOR116C RPO31 SGTC_1738 st035555 74 µM 0.481191928135716 0.308527208415625 no 1036 0.315190048594107 1514 5331140 SGTC_466 geldanamycin 89.2 µM 0.480219801658354 0.308866251347084 no 1037 0.315535553999765 1481 5288382 HSP90 inhibitor. SGTC_1850 st056238 17 µM 0.479577844304786 0.309090232448761 no 1038 0.315763801801266 1490 5393177 SGTC_3217 9129673 49.47 µM 0.478612154829629 0.309427298483247 no 1039 0.316107284847945 1508 17248312 SGTC_2588 indole-3-carbinol 100 µM 0.477746903678076 0.309729443600713 no 1040 0.316415178188174 1631 3712 Induces cell cycle arrest. SGTC_768 0384-0033 77.3 µM 0.476744573852944 0.310079617277077 no 1041 0.316772009117101 1478 3965305 YMR134W ERG29 SGTC_493 zm226600 134 µM 0.475193486886484 0.310621844186854 no 1042 0.317324534493875 1542 5240098 A potassium channel opener. YCR052W RSC6 SGTC_1877 wortmannin 25 µM 0.475120638350013 0.310647320610904 no 1043 0.317350494491292 1563 312145 A covalent inhibitor of PI 3-kinase. SGTC_1822 st052468 42 µM 0.475029498871872 0.310679194980044 no 1044 0.317382973836851 1482 2873678 SGTC_2213 7173844 200 µM 0.474469098312051 0.310875216074803 no 1045 0.317582714496197 1494 892728 SGTC_566 0958-0068 16.5 µM 0.472862204925048 0.31143758475315 no 1046 0.318155745503517 1535 6815365 SGTC_2116 5511452 16.8835 µM 0.472724584019375 0.311485768786312 no 1047 0.318204842482938 1540 870744 SGTC_2565 isoliquiritigenin 100 µM 0.472167486299806 0.311680853640869 no 1048 0.318403622643306 1434 638278 Binds to benzodiazepine receptor 65X better than valium. SGTC_2192 5915882 198.485 µM 0.471122734113496 0.312046848166972 no 1049 0.318776545608406 1508 2876149 SGTC_1882 5615643 20 µM 0.471015644389054 0.312084374019755 no 1050 0.318814781529065 1468 2253075 SGTC_898 1000-0849 28.3 µM 0.465875206039914 0.313887948546624 no 1051 0.320652414669683 1543 6751807 SGTC_1031 k035-0009 16 µM 0.465742312110176 0.31393463498278 no 1052 0.320699980937726 1650 5180959 SGTC_3141 9094609 49.47 µM 0.465726227924772 0.313940285655853 no 1053 0.320705738094734 1470 25236309 YDL196W YDL196W SGTC_723 4182-0001 115 µM 0.464409497061646 0.314403025554708 no 1054 0.321177193575254 1502 744821 YLR208W SEC13 SGTC_724 3910-0327 137 µM 0.463827301754335 0.314607720040711 no 1055 0.321385740585032 1495 2885483 SGTC_864 0469-0573 172 µM 0.46305784682898 0.314878340710366 no 1056 0.321661451887472 1497 689425 SGTC_2775 cyproheptadine 69.59 µM 0.462796791808629 0.31497017750204 no 1057 0.32175501552351 1538 2913 A selective serotonin reuptake inhibitor. SGTC_1179 1021-1431 9.29 µM 0.462394785577963 0.315111622025787 no 1058 0.321899118998423 1553 2840958 SGTC_547 1120-0019 610 nM 0.46173449694868 0.315344001164132 no 1059 0.322135864715799 1553 3676939 SGTC_1484 3473-2379 286 µM 0.461717764234813 0.315349890953066 no 1060 0.322141865149046 1601 671917 SGTC_3073 9114972 49.47 µM 0.4615315497905 0.315415440197921 no 1061 0.322208645690312 1631 41905075 SGTC_2340 7987427 183.45 µM 0.460982226251053 0.315608841118572 no 1062 0.3224056784665 1568 2239331 SGTC_1605 st000082 49.1 µM 0.4598549405109 0.316005883948204 no 1063 0.322810172429392 1589 1114022 SGTC_2043 5101342 149 µM 0.459827875012314 0.316015419335795 no 1064 0.322819886682587 1530 678451 SGTC_3283 9109332 35.8195 µM 0.45804817380678 0.316642690430461 no 1065 0.323458915834594 1490 17027281 SGTC_1441 4106-0040 13 µM 0.457588487259644 0.316804796752304 no 1066 0.323624058127893 1523 2904180 SGTC_1221 2958-7315 257 µM 0.456887637270137 0.317052015940991 no 1067 0.323875905187501 1542 4562705 SGTC_1050 3232-1156 69.3 µM 0.454984773422236 0.317723647553559 no 1068 0.324560096622586 1504 700529 SGTC_3352 9151559 45.5865 µM 0.454419108301619 0.317923419598973 no 1069 0.324763600848763 1492 17159339 SGTC_3097 9117246 49.47 µM 0.453884300231509 0.318112342817944 no 1070 0.324956052027992 1528 16423892 SGTC_1468 k284-1086 134 µM 0.453341742219218 0.318304052106886 no 1071 0.325151339772804 1541 15996457 SGTC_1530 rhein 70.4 µM 0.452798915194447 0.318495905161004 no 1072 0.325346772421105 1552 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death. SGTC_3092 9117248 49.47 µM 0.452493621333214 0.318603827516877 no 1073 0.325456707712629 1641 17141857 SGTC_2799 7812892 81.82 µM 0.451806882812142 0.318846648015014 no 1074 0.325704055436585 1646 20205235 SGTC_907 3448-6986 75.5 µM 0.449435452437615 0.319685747967867 no 1075 0.326558780750746 1648 590582 SGTC_2408 sulbentine 18.36 µM 0.448363860360601 0.320065220266597 no 1076 0.32694530968284 1642 67686 An antifungal agent of unknown mechanism. YDL205C HEM3 SGTC_1076 itraconazole 331 nM 0.448141369224657 0.320144032472858 no 1077 0.327025586712555 1547 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1 SGTC_2160 5660466 132.927 µM 0.447417489047645 0.320400505992835 no 1078 0.327286825300047 1629 2859134 SGTC_2630 antimycin a 100 µM 0.446857265266622 0.320599054330172 no 1079 0.327489060596247 1483 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain. SGTC_298 1391-0729 10 µM 0.446445242648709 0.320745111615345 no 1080 0.327637829041062 1542 3237558 SGTC_2418 pentamidine 31.67 µM 0.444778746053572 0.321336148464092 no 1081 0.32823982769175 1489 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_1130 3454-2858 15.9 µM 0.444218461450799 0.321534959813338 no 1082 0.328442323022002 1513 715628 YIL048W NEO1 SGTC_2277 7947813 106.88 µM 0.444165599602016 0.321553719948433 no 1083 0.328461430696688 1672 1246798 SGTC_3161 9100388 49.47 µM 0.443937652426261 0.321634621305889 no 1084 0.328543830616075 1621 25236368 SGTC_2986 9022445 71.43 µM 0.442888411006704 0.322007119490147 no 1085 0.328923225129453 1669 6459286 SGTC_1203 3992-3522 103 µM 0.442513856243837 0.322140136021242 no 1086 0.329058702868154 1776 5322312 SGTC_1691 st019933 84.6 µM 0.440991869921545 0.322680876924562 no 1087 0.32960944139016 1625 6176082 SGTC_2496 diffractaic acid 79.83 µM 0.438543478025878 0.323551544010364 no 1088 0.330496179939679 1686 94870 An apoptosis inducer which activates caspases. SGTC_2724 maprotiline 69.64 µM 0.436731231741264 0.324196615828631 no 1089 0.33115313822578 1628 4011 A tricyclic antidepressant. SGTC_596 1155-0152 116 µM 0.436007291870881 0.324454451053817 no 1090 0.331415719518272 1559 280313 SGTC_2367 9070478 135.38 µM 0.435396688848793 0.324671986174697 no 1091 0.331637256685144 1574 572802 SGTC_5 0352-0601 109.883 µM 0.434789108326187 0.324888503869873 no 1092 0.331857755705722 1580 762456 SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM 0.434345001889771 0.325046803293151 no 1093 0.332018964672355 1615 17037758 SGTC_331 k048-0133 24.5 µM 0.433886096531594 0.325210410899228 no 1094 0.332185578262867 1554 6813582 SGTC_1694 st024011 44.9 µM 0.433659689562801 0.325291141271309 no 1095 0.332267791484022 1601 2787533 SGTC_1859 st055998 20 µM 0.433420314796814 0.325376504513857 no 1096 0.332354722369265 1721 676301 SGTC_3223 9129970 49.47 µM 0.432984900676474 0.325531800680575 no 1097 0.332512869655428 1605 17248386 SGTC_393 acivicin 6.25 µM 0.432345089637652 0.325760052646949 no 1098 0.332745310284789 1574 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1 SGTC_641 4092-0595 30 µM 0.431973706444881 0.325892573213314 no 1099 0.332880261721229 1623 786260 SGTC_692 k241-0027 77.8 µM 0.43029091194503 0.326493319792809 no 1100 0.333492018583669 1667 3600480 SGTC_501 nsc-95397 161 µM 0.430191048589888 0.326528984522899 no 1101 0.333528336479536 1648 262093 SGTC_3356 9151811 4.48 µM 0.429970827377537 0.326607638896939 no 1102 0.333608431141555 1553 1859254 YPR165W RHO1 SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM 0.427520897649111 0.327483176829217 no 1103 0.334499983687147 1574 6708784 An antioxidant flavonoid SGTC_115 0527-0192 112.043 µM 0.427483962506742 0.327496383718072 no 1104 0.334513431893876 1586 4233931 SGTC_1309 pyrazolanthrone 13.4 µM 0.427394727880279 0.327528292210068 no 1105 0.33454592339083 1678 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14 SGTC_1422 4031-0024 15.5 µM 0.426920405812157 0.327697921299965 no 1106 0.334718651066511 1589 782427 SGTC_1913 st060213 96.1 µM 0.426413825990223 0.327879125821721 no 1107 0.334903164256348 1709 688959 SGTC_1232 0279-0259 161 µM 0.425624086243252 0.32816169799605 no 1108 0.335190893187895 1571 1560000 SGTC_1591 genipin 88.4 µM 0.424196872330304 0.328672610508501 no 1109 0.335711120809546 1663 442424 A DNA cross-linking agent. SGTC_2923 7992654 58.14 µM 0.42415997078826 0.328685824736437 no 1110 0.335724575814335 1589 2985126 SGTC_3123 9126162 49.47 µM 0.422120816471614 0.329416366630132 no 1111 0.336468417242867 1614 25239884 SGTC_3229 9132204 49.47 µM 0.421790768027078 0.329534670231578 no 1112 0.336588872402334 1641 17682924 SGTC_101 0490-5701 117.494 µM 0.421630228614125 0.329592220652077 no 1113 0.336647469259883 1674 4661669 SGTC_151 3013-0144 2.285 µM 0.420935634365659 0.329841266378087 no 1114 0.336901041728898 1666 906558 YHR107C CDC12 SGTC_183 3914-0051 30.55 µM 0.420234909129421 0.330092586816915 no 1115 0.337156927545231 1741 1596232 SGTC_2851 9015922 71.43 µM 0.419460451184719 0.3303704412735 no 1116 0.337439826212516 1669 2996893 SGTC_2485 5633444 17.78 µM 0.416671581134727 0.331371786102594 no 1117 0.338459321935918 1549 5724239 SGTC_11 0438-0307 1.3 µM 0.415880639241261 0.331655994045975 no 1118 0.338748673678606 1698 4011476 SGTC_1755 st041960 45.185 µM 0.413345312422788 0.332567661848831 no 1119 0.339676817884813 1614 2257073 SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM 0.411073949909224 0.333385253868748 no 1120 0.340509155424259 1739 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair. SGTC_3172 9105863 49.47 µM 0.410233696297694 0.333687909684062 no 1121 0.340817262362835 1655 2348785 SGTC_1494 4358-1428 177 µM 0.409138486415726 0.334082562165719 no 1122 0.34121901693107 1748 1564571 SGTC_1844 rapamycin 4 nM 0.407443589784584 0.334693669939573 no 1123 0.341841108696396 1619 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2 SGTC_1753 st043925 64 µM 0.407039818902148 0.33483931725757 no 1124 0.341989371463461 1696 670181 SGTC_3185 9108267 49.47 µM 0.406792347470102 0.334928596874938 no 1125 0.342080253854507 1569 4910486 SGTC_645 0845-0943 5.41 µM 0.406355909917052 0.335086072035677 no 1126 0.34224055520771 1609 1885106 SGTC_1668 st014914 51.6 µM 0.40511279024582 0.335534772623698 no 1127 0.342697302649615 1615 2839556 SGTC_2287 7945887 168.79 µM 0.404681464865771 0.335690513185713 no 1128 0.342855834158177 1715 1245853 SGTC_380 3970-0968 6 µM 0.403693930765755 0.336047192751744 no 1129 0.343218901602162 1588 2891601 SGTC_2568 diosmetin 100 µM 0.403658731359509 0.33605990887218 no 1130 0.343231845356626 1667 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.  SGTC_3019 9081971 49.47 µM 0.399023633956343 0.337736016132855 no 1131 0.344937895015253 1732 16451803 SGTC_1314 1222-0010 41.1 µM 0.396363734708917 0.338699325798993 no 1132 0.345918357721529 1649 3526027 SGTC_2272 7805186 180 µM 0.395663727475424 0.338953016363743 no 1133 0.346176558806516 1690 2956062 YPR165W RHO1 SGTC_3177 9107506 49.47 µM 0.395424889698483 0.339039590605182 no 1134 0.346264671656461 1713 8897194 SGTC_125 0133-0007 11.75 µM 0.394534256376428 0.339362503502778 no 1135 0.346593320493078 1810 26541 SGTC_105 0111-0055 734.78 µM 0.393578900676754 0.339709013670659 no 1136 0.346945980652719 1638 5179370 SGTC_3032 9089427 49.47 µM 0.392207767398778 0.340206564276279 no 1137 0.347452352715823 1601 17173707 SGTC_1875 nocodazole 6 µM 0.392129069443929 0.340235130286913 no 1138 0.347481424863775 1712 4122 A microtubule depolymerizer. YJL014W CCT3 SGTC_2677 mitomycin C 100 µM 0.392035567627852 0.34026907103767 no 1139 0.347515966935577 1638 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_630 4356-0227 183 µM 0.392006987821621 0.340279445640719 no 1140 0.347526525333113 1645 779312 SGTC_3051 9093778 49.47 µM 0.3918240784244 0.340345845468157 no 1141 0.347594101374721 1652 17217378 SGTC_2522 biochanin a 4.94 µM 0.389593406451007 0.341156022477004 no 1142 0.348418614270687 1687 5280373 A possible chelator. SGTC_1400 3771-8998 51.5 µM 0.388445232651924 0.341573323563553 no 1143 0.348843288078427 1698 670767 SGTC_224 benfluorex 43.875 µM 0.386153542626215 0.342406811754094 no 1144 0.349691478954194 1746 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis. SGTC_2484 5809818 12.04 µM 0.38395908581787 0.343205656272992 no 1145 0.35050438614005 1668 2870548 SGTC_208 k072-0098 12.366 µM 0.383725295431174 0.343290803995023 no 1146 0.350591031111515 1655 5948901 SGTC_1617 st002906 78 µM 0.377853210944971 0.345432048126534 no 1147 0.352769821140008 1649 5150859 SGTC_1415 3966-0071 78.1 µM 0.377847456332971 0.345434148976312 no 1148 0.352771958727065 1678 2893185 SGTC_81 0411-0046 9.971 µM 0.377579063823965 0.345532136951616 no 1149 0.352871659986158 1622 12925265 SGTC_1200 1643-0193 18.4 µM 0.375851900746213 0.346162957885905 no 1150 0.353513500328535 1711 5403974 SGTC_2564 betulinic acid 100 µM 0.375283904911639 0.346370503424953 no 1151 0.353724667460727 1864 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14 SGTC_2077 5212015 200 µM 0.373827672745709 0.346902820953384 no 1152 0.354266264926277 1590 780900 SGTC_962 1254-0300 21.5 µM 0.372819570282681 0.347271504326192 no 1153 0.354641368153415 1677 7340576 SGTC_639 0833-0042 114 µM 0.372229920971557 0.347487217989665 no 1154 0.354860835198185 1630 5978911 YPR085C | YHR062C ASA1 | RPP1 SGTC_133 0724-0033 378.92 µM 0.371396905023915 0.347792047580424 no 1155 0.355170965215935 1649 280309 SGTC_2685 mycophenolic acid 18.85 µM 0.371116031013478 0.347894851373796 no 1156 0.355275555638901 1729 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_3000 9075062 71.4286 µM 0.370522182913124 0.348112244843629 no 1157 0.355496725633559 1661 17057871 SGTC_2323 6148992 148.28 µM 0.369691500894455 0.348416421246951 no 1158 0.355806182580541 1633 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42 SGTC_916 4466-0038 42 nM 0.366955088027997 0.349419120636754 no 1159 0.356826259527209 1781 5722064 YGL116W CDC20 SGTC_2356 9061756 188.97 µM 0.365357413018641 0.350005040910521 no 1160 0.357422313312681 1793 20104043 SGTC_1235 benzylparaben 21.5 µM 0.365254468319006 0.350042806404528 no 1161 0.357460731431731 1688 7180 SGTC_3162 9099653 49.47 µM 0.365156812002263 0.350078633214311 no 1162 0.357497177304768 1731 25237511 SGTC_2606 farnesol 9.78 µM 0.364781178573101 0.350216452889702 no 1163 0.357637377872403 1765 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_2057 5236571 38.335 µM 0.36314632500451 0.350816509226836 no 1164 0.358247790448439 1793 54684039 YBR257W POP4 SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM 0.3587006856143 0.352450114874804 no 1165 0.359909507715171 1769 6710655 SGTC_1358 1509-0022 2.48 µM 0.358634867774935 0.35247432100771 no 1166 0.35993412948727 1712 3258434 SGTC_2020 4017018 200 µM 0.358459651668944 0.352538763962152 no 1167 0.359999678850795 1676 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope. SGTC_2017 5132927 60.65 µM 0.358319481368983 0.352590320422529 no 1168 0.360052120338966 1621 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis SGTC_2913 7966556 36.57 µM 0.356948622444872 0.353094682788214 no 1169 0.360565134328703 1788 2976516 SGTC_1807 st050092 58.9 µM 0.35684642111546 0.353132294752013 no 1170 0.360603391010462 1678 5008496 SGTC_2551 apiole 73.87 µM 0.356605263288794 0.353221050942279 no 1171 0.360693668342823 1717 10659 A possible DNA adduct former. SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM 0.355813142501799 0.353512640763059 no 1172 0.360990253040191 1647 4174840 SGTC_2322 7413319 38.22 µM 0.355353980551941 0.353681703545602 no 1173 0.361162210067483 1713 1840400 SGTC_947 3447-0010 211 µM 0.354081936001107 0.35415021920867 no 1174 0.361638739629187 1671 748350 SGTC_3156 9099931 49.47 µM 0.353970305260575 0.354191345262878 no 1175 0.361680568662869 1709 18111053 SGTC_80 0159-0065 512.242 µM 0.353350600143688 0.354419682700391 no 1176 0.361912807739055 1795 1548079 SGTC_1297 1068-0111 14.1 µM 0.352132408500444 0.354868691837278 no 1177 0.362369482249735 1644 767057 SGTC_727 3032-0951 202 µM 0.351233267319811 0.355200232641312 no 1178 0.362706677146559 1735 3652836 SGTC_3214 9129694 49.47 µM 0.349588692880781 0.355806920964355 no 1179 0.363323698955796 1817 17158655 SGTC_1498 4478-3555 97.6 µM 0.346623661048524 0.356901652266001 no 1180 0.364437033892032 1806 3437919 SGTC_2313 7726885 200 µM 0.346000388116635 0.357131923689363 no 1181 0.364671211528868 1710 726423 SGTC_713 1488-1073 324 µM 0.344219010520281 0.357790349612407 no 1182 0.365340793284764 1792 3312542 SGTC_1885 st057546 99.9 µM 0.342669294907327 0.358363493981307 no 1183 0.365923632379577 1800 702008 SGTC_1101 ebselen 5.29 µM 0.342654648810486 0.358368912195365 no 1184 0.365929142170767 1848 3194 A potent scavenger of hydrogen peroxide and hydroperoxides. SGTC_42 0133-0086 60.653 µM 0.340749220086834 0.359074054122542 no 1185 0.366646190713744 1622 162923 Model of phenazepam hydroxylation. SGTC_261 5-fluorouridine 15.376 µM 0.340228171990636 0.35926696211721 no 1186 0.366842352063454 1799 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_1198 1612-1005 86.7 µM 0.338306740145387 0.359978644942495 no 1187 0.367566022483 1821 6998509 SGTC_1025 k007-0731 70 µM 0.336469360680197 0.360659649781596 no 1188 0.368258476355421 1688 6256118 SGTC_838 0109-0203 71.4 µM 0.336443786991173 0.360669131517666 no 1189 0.368268117347385 1714 759422 SGTC_1819 st053448 58.6 µM 0.336418384566 0.360678549840513 no 1190 0.368277693856933 1737 2857616 SGTC_2516 gossypol 71.55 µM 0.334479514294876 0.361397663515888 no 1191 0.369008873425131 1844 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_2848 9016370 25.97 µM 0.332591713156285 0.36209830683137 no 1192 0.369721249768584 1886 7894410 SGTC_1983 st071813 46.9 µM 0.329283396852405 0.363327277645718 no 1193 0.370970746204018 1751 11838595 SGTC_553 k007-0256 45.7 µM 0.328889949971746 0.36347352893282 no 1194 0.371119435446712 1757 6287000 SGTC_894 0960-0238 55.9 µM 0.328751160626941 0.363525124179705 no 1195 0.371171890530991 1791 6741907 YDL195W SEC31 SGTC_1681 tripelennamine 100 µM 0.328068079037153 0.36377909733544 no 1196 0.371430094363285 1693 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist. SGTC_426 0988-0037 14.6 µM 0.326223445150454 0.364465240273798 no 1197 0.372127652085931 1910 5383008 SGTC_988 1497-1057 103 µM 0.325867697070598 0.364597616866803 no 1198 0.37226222840207 1901 3533044 SGTC_2815 7968870 71.43 µM 0.325159317475049 0.364861258431451 no 1199 0.372530248515637 1693 2977326 YHR190W ERG9 SGTC_3027 9089541 49.47 µM 0.325068160893523 0.364895189326001 no 1200 0.372564742698554 1734 9943819 SGTC_1975 st070967 30.8 µM 0.324567521645052 0.36508155937401 no 1201 0.372754205730087 1871 261391 SGTC_535 2293-4129 48.2 µM 0.323642071873965 0.36542615504455 no 1202 0.373104516030237 1858 396118 YIL048W NEO1 SGTC_2411 st077133 39.94 µM 0.321688821494747 0.366153813605925 no 1203 0.373844223616319 1891 1403142 YNL221C POP1 SGTC_2904 7225135 42.03 µM 0.320728768341057 0.366511645887632 no 1204 0.374207972059566 1843 4446116 SGTC_1830 st055982 50.3 µM 0.314924439559845 0.368677505056567 no 1205 0.376409512488941 1887 455313 An antimicrobial agent. SGTC_1795 st049545 62.3 µM 0.314643547909906 0.368782425046617 no 1206 0.376516155401764 1903 5291882 SGTC_188 3229-0966 278.469 µM 0.314172416437635 0.368958426280128 no 1207 0.376695045646205 1882 5722370 SGTC_2023 5144124 124 µM 0.313154315222847 0.369338853570205 no 1208 0.377081712582067 1740 2830192 SGTC_1322 1348-1070 12 µM 0.311959928080926 0.369785315608319 no 1209 0.377535488687645 1858 6758089 SGTC_891 0929-0073 133 µM 0.311801921560011 0.36984439162578 no 1210 0.377595531804237 1830 5603632 SGTC_734 2023-0417 80 µM 0.310878662553279 0.370189644227859 no 1211 0.377946433057848 1820 3935732 SGTC_1520 flindersine 88 µM 0.308565506332994 0.371055107598349 no 1212 0.378826031581726 1912 68230 Flindersine is a natural alkaloid of the quinoline subtype. SGTC_1374 2889-5571 141 µM 0.308175126745646 0.371201231921512 no 1213 0.378974538998509 1746 2853281 SGTC_2693 st077581 40.7 µM 0.307409563729979 0.371487846340243 no 1214 0.379265824797443 1818 25238761 SGTC_2929 9013348 24.6 µM 0.307358471888806 0.371506976838274 no 1215 0.37928526695581 1765 2995952 SGTC_1369 1866-0067 208 µM 0.307205807672762 0.371564141329226 no 1216 0.379343362626856 1857 3531355 SGTC_1980 st071811 45.7 µM 0.306727904792308 0.371743108414159 no 1217 0.379525243997634 1842 4974850 SGTC_969 1313-0238 134 µM 0.306572274460316 0.371801395502382 no 1218 0.379584479902288 1758 5212874 SGTC_1757 st041620 31.8375 µM 0.304018115143718 0.372758405043657 no 1219 0.380557045043225 1735 5289815 SGTC_2284 7945075 39.21 µM 0.301691918264392 0.373630684167606 no 1220 0.381443464843686 1924 1245402 SGTC_3323 9138564 53.9225 µM 0.300582655067883 0.374046864924609 no 1221 0.381866379700407 1910 43912313 YNL103W MET4 SGTC_1346 1488-2224 62.4 µM 0.299929416588764 0.37429202002844 no 1222 0.382115497749058 1908 3722427 SGTC_1326 1431-2094 10.8 µM 0.298478872892752 0.374836578967909 no 1223 0.382668849321708 1725 616278 SGTC_2155 5570423 76 µM 0.298465598885755 0.374841563411793 no 1224 0.382673914181172 1776 797402 SGTC_2390 9097792 176.6 µM 0.296983615289085 0.375398185599515 no 1225 0.383239509110818 1706 4497149 SGTC_1889 st059080 5.18 µM 0.296232618457486 0.375680353658761 no 1226 0.383526220096748 1927 176925 Isolated from Daphnopsis sellowiana. SGTC_2092 5303694 80.6725 µM 0.295237569531396 0.376054320529771 no 1227 0.383906202032516 1749 1963699 SGTC_676 falcarinol 140 µM 0.295080626369293 0.376113314743215 no 1228 0.383966144530411 1909 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer. SGTC_2440 5628896 157.78 µM 0.294812106990763 0.376214256656914 no 1229 0.384068708620167 1786 5522048 SGTC_367 0335-0881 7.1 µM 0.294339085064583 0.376392095845372 no 1230 0.38424940457484 1866 23828853 SGTC_917 harmaline 728.087 nM 0.293777526315067 0.376603255755421 no 1231 0.384463954552973 1833 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7 SGTC_1896 st058441 89 µM 0.292118154805032 0.377227435838996 no 1232 0.38509814312632 1753 688759 SGTC_1734 st037168 69.4 µM 0.291335785028868 0.377521839180637 no 1233 0.385397260670146 1750 708907 SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM 0.290989145743984 0.377652301242956 no 1234 0.38552981046513 1805 368090 SGTC_995 3931-2021 34.6 µM 0.290208778977671 0.377946053172904 no 1235 0.385828260218275 1823 730143 SGTC_1797 st048695 56.8 µM 0.289302030488158 0.378287467378288 no 1236 0.386175129309644 1904 592262 YIL048W NEO1 SGTC_2586 curcumin 80 µM 0.288870096613476 0.378450135068268 no 1237 0.386340394036311 1872 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40 SGTC_35 0133-0054 64.071 µM 0.288150542519782 0.378721169282619 no 1238 0.386615752581904 1713 99677 SGTC_1138 3761-0006 1.03 µM 0.28783476959906 0.378840130212269 no 1239 0.386736610415754 1836 12061087 SGTC_555 4296-0685 37 µM 0.286637928594343 0.379291119472032 no 1240 0.387194784826224 1829 2908540 YHR072W ERG7 SGTC_109 0132-0036 33.701 µM 0.286606204034412 0.379303076043132 no 1241 0.387206931756727 1908 67274 A color developer. SGTC_1560 lithocholic acid 53.1 µM 0.284881514913843 0.379953262240114 no 1242 0.387867459198208 1916 9903 A bile acid which acts as a detergent. SGTC_266 formosanin C 406 nM 0.28443629398889 0.380121160152657 no 1243 0.388038024245464 1867 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1 SGTC_2139 5578692 56.4705 µM 0.283693092102499 0.38040148042272 no 1244 0.388322794518703 1921 650991 YMR113W FOL3 SGTC_1586 deoxycorticosterone acetate 53.7 µM 0.281232566766497 0.381329986840048 no 1245 0.389266013776953 1902 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE. SGTC_1873 rapamycin 2 nM 0.281010873510514 0.381413678882748 no 1246 0.389351029945001 1774 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1 SGTC_1060 3448-7350 82 µM 0.279674479187778 0.381918302191185 no 1247 0.389863629964739 1920 570178 SGTC_2232 chlorophetanol 41.5365 µM 0.278624301139258 0.382314990933771 no 1248 0.390266580668868 1896 15907 An antifungal of unknown mechanism. YFR051C RET2 SGTC_2308 7584454 197.62 µM 0.278500457330635 0.382361779195597 no 1249 0.390314107011089 1902 893577 SGTC_86 0417-1630 471.922 µM 0.277916386002232 0.382582464818894 no 1250 0.390538272507827 1926 3634867 SGTC_3281 9140613 49.47 µM 0.277799688563531 0.382626562374712 no 1251 0.390583065133178 1718 16013766 SGTC_2665 lovastatin 100 µM 0.27695472956108 0.382945900327277 no 1252 0.390907433722207 1805 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1 SGTC_487 nimodipine 119 µM 0.276950598533025 0.382947461775058 no 1253 0.390909019755917 1921 4497 L-type voltage-gated calcium channels inhibitor SGTC_461 N-acetylfarnesylcysteine 136 µM 0.276321698597631 0.383185195819631 no 1254 0.391150495693563 1893 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ). SGTC_6 0844-0013 19.835 µM 0.274820215745585 0.383752957672317 no 1255 0.39172718298898 1892 1584900 SGTC_60 0986-0278 202 µM 0.274817052706021 0.383754153989333 no 1256 0.39172839809615 1655 3110598 SGTC_780 0109-0199 192 µM 0.274225650986166 0.383977851946137 no 1257 0.391955608387563 1953 610414 SGTC_3206 9114350 49.47 µM 0.271919755406171 0.384850426555925 no 1258 0.392841860382722 1901 17087243 SGTC_94 0334-0113 514.748 µM 0.27167698563864 0.384942327161754 no 1259 0.392935199363677 1729 6795178 SGTC_1881 5652484 16 µM 0.271562790221865 0.384985558124385 no 1260 0.392979106810958 1933 2255129 SGTC_842 0271-0008 11.1 µM 0.270085059141297 0.385545111603943 no 1261 0.393547408102051 1890 1221709 SGTC_1062 mesoridazine 14.2 µM 0.269702194283936 0.385690125045992 no 1262 0.393694686145214 1832 4078 A neuroleptic. SGTC_1180 1193-0155 285 µM 0.269510206709947 0.385762848049556 no 1263 0.39376854444316 1810 2921347 SGTC_2782 7736369 71.43 µM 0.269198217339817 0.385881035116042 no 1264 0.393888576006304 1788 2950836 YOL077C BRX1 SGTC_1152 3909-8331 15.9 µM 0.26718940790577 0.386642260743243 no 1265 0.394661665529364 1821 16001939 SGTC_1247 0448-0043 5.84 µM 0.266515057679297 0.38689789947511 no 1266 0.394921282146138 1819 3089013 YGL099W LSG1 SGTC_2942 9052777 62.25 µM 0.266378229416131 0.386949775552784 no 1267 0.394973965057747 1826 6469503 SGTC_1063 disulfiram 1.84 µM 0.266013209441656 0.387088176462754 no 1268 0.395114517891325 1845 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_2806 7952793 58.44 µM 0.265941959002206 0.387115193442141 no 1269 0.395141954835035 1863 2972490 SGTC_2701 st077767 14.721 µM 0.265741591471582 0.387191172401966 no 1270 0.395219114656465 1820 5721188 SGTC_2471 5466956 24.79 µM 0.265676914123234 0.387215698843699 no 1271 0.395244022227142 1868 724419 SGTC_1972 st070201 17.4 µM 0.264977438800276 0.387480977189375 no 1272 0.395513420999745 1952 2829099 SGTC_782 0083-0095 30.5 µM 0.26485647237784 0.387526859440445 no 1273 0.395560015568132 1830 3591729 An indicator and reagent. SGTC_1553 gossypol 38.6 µM 0.263983146152795 0.387858156390665 no 1274 0.395896452829915 1881 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_717 1532-0246 73.2 µM 0.263416118305856 0.388073302555534 no 1275 0.396114934281596 1827 9561992 SGTC_1700 st030840 7.9285 µM 0.262890599135617 0.388272729850548 no 1276 0.396317451169603 1962 5499307 SGTC_202 3594-0513 34.79 µM 0.262827041525754 0.388296851087139 no 1277 0.396341945968949 1926 708429 SGTC_659 k018-0002 107 µM 0.260865583033685 0.389041470656271 no 1278 0.397098083422077 1973 6797879 YHR007C ERG11 SGTC_314 1671-0008 2.74 µM 0.259975981840127 0.389379320476055 no 1279 0.397441150231984 1874 3913060 SGTC_1849 st056239 19.2 µM 0.259832776281839 0.38943371443439 no 1280 0.39749638360706 1741 5393181 SGTC_1248 0469-0687 58.6 µM 0.259083065528761 0.389718513404019 no 1281 0.397785575283392 1892 4017482 SGTC_986 1493-0483 84 µM 0.258899795447604 0.389788142775522 no 1282 0.397856278007531 1968 40079 SGTC_954 1189-0853 2.85 µM 0.25770069035797 0.390243803143431 no 1283 0.39831895663413 1926 2828194 SGTC_161 4065-0411 162.148 µM 0.257099880938073 0.390472167697491 no 1284 0.398550834728548 1862 1906281 YLR208W SEC13 SGTC_567 1080-0542 68.4 µM 0.257055544104498 0.390489021396925 no 1285 0.398567947632241 1956 5950415 SGTC_1561 5-methoxyflavone 52.9 µM 0.255859603898865 0.390943710035679 no 1286 0.399029623982701 1964 94525 SGTC_1908 st060353 56.5 µM 0.253734231374415 0.391752130393987 no 1287 0.399850443233462 2015 4227716 SGTC_1631 benzylvanillin 81.9 µM 0.253214540507662 0.391949874640225 no 1288 0.400051215441466 1867 75506 SGTC_1462 k081-0014 26.5 µM 0.251881524284556 0.392457219625184 no 1289 0.400566320374628 1819 3270634 SGTC_824 1304-0008 100 µM 0.246052011290623 0.394678065249733 no 1290 0.4028209853117 1873 768245 SGTC_2339 9000433 200 µM 0.245287770082567 0.394969470725565 no 1291 0.403116810308668 1787 2988954 SGTC_1782 st039423 80.636 µM 0.244282035701601 0.395353047167962 no 1292 0.403506197766633 1813 2068169 SGTC_1955 wogonin 32.4 µM 0.243714860895137 0.395569406377239 no 1293 0.40372583151736 1968 5281703 A flavanone. SGTC_1658 st012944 20 µM 0.243648178437642 0.395594845736853 no 1294 0.403751655743198 1946 24207260 SGTC_1007 4101-0031 70 µM 0.243477559902919 0.395659938738126 no 1295 0.403817733375879 1991 1146276 SGTC_1500 4488-1866 171 µM 0.242978889205775 0.395850204221086 no 1296 0.404010875714865 1981 2900003 SGTC_353 1988-1175 58.3 µM 0.240798433515585 0.396682437888853 no 1297 0.404855671888964 1811 2788357 SGTC_1371 2421-0008 32.7 µM 0.239182465146877 0.397299522746045 no 1298 0.40548204944969 1849 2827552 SGTC_2988 9073640 71.4286 µM 0.239152282288955 0.397311051032079 no 1299 0.40549375116098 1904 9102229 SGTC_1650 st011916 45.8 µM 0.239081641829863 0.397338032373734 no 1300 0.405521138369475 1996 242528 SGTC_1747 st037496 66.6 µM 0.238744477517165 0.397466820090914 no 1301 0.405651862878409 1862 723305 SGTC_2119 5528445 120.635 µM 0.238079562977406 0.397720832342889 no 1302 0.405909692716354 1983 791935 SGTC_2786 7743617 45.45 µM 0.237869842421983 0.397800959295769 no 1303 0.405991023244141 1801 583674 SGTC_1630 st005209 31.3 µM 0.237836113666618 0.397813846286298 no 1304 0.406004103778465 2037 3367314 SGTC_2030 5175110 200 µM 0.233886006489447 0.39932386001796 no 1305 0.407536738577224 1947 2831986 SGTC_609 0986-0026 86.3 µM 0.233561053560707 0.399448147701314 no 1306 0.407662883125202 1920 2848610 SGTC_2910 7948405 25.97 µM 0.232438555916129 0.399877557850728 no 1307 0.408098702763391 2009 2971328 SGTC_2152 5568786 200 µM 0.232297448383345 0.399931546950507 no 1308 0.408153497068401 1913 5399883 SGTC_244 nsc-207895 1.295 µM 0.232141008943615 0.399991404421333 no 1309 0.408214247096773 1873 42640 SGTC_2359 9039622 200 µM 0.231803585969999 0.400120518518714 no 1310 0.408345285855404 1947 6463596 SGTC_2177 5811945 192 µM 0.230303141069949 0.400694792223881 no 1311 0.408928109994563 1974 5343475 SGTC_358 0075-0058 9.45 µM 0.229168330629003 0.401129267265957 no 1312 0.40936904305141 2118 1069125 SGTC_369 0957-0393 4.5 µM 0.229070874896 0.401166585008054 no 1313 0.409406915042771 1826 6997992 SGTC_927 2425-1185 123 µM 0.227767025652559 0.401665941463894 no 1314 0.409913681325339 1849 730375 SGTC_1006 4099-6547 255 µM 0.226464818562018 0.402164829308432 no 1315 0.410419959588123 1971 3146833 SGTC_817 1391-0715 46 µM 0.226012420065092 0.402338184803192 no 1316 0.410595880217533 1862 1353946 SGTC_3327 9140648 26.9345 µM 0.222944813518781 0.403514172238897 no 1317 0.411789228931769 2005 8029710 SGTC_2495 cafestol 54.53 µM 0.222076004317939 0.403847395130269 no 1318 0.412127358626895 1950 16667697 An anti-infammatory. SGTC_1139 k015-0024 46.9 µM 0.221999903039638 0.403876586325926 no 1319 0.412156979405723 2039 2766652 SGTC_2717 st081029 62.2815 µM 0.22187879960594 0.403923040710208 no 1320 0.412204117333271 2037 5292846 SGTC_1781 st038725 66.3 µM 0.220068457302247 0.404617635859563 no 1321 0.41290892002173 1856 4270275 YIL048W NEO1 SGTC_1009 4106-0057 9.87 µM 0.219948329398232 0.40466373739624 no 1322 0.412955698192688 2056 2928005 SGTC_1897 st060201 15 µM 0.218373609488709 0.405268190482251 no 1323 0.41356901296773 1844 611878 SGTC_1659 st012954 42.1 µM 0.217689737111214 0.405530764005776 no 1324 0.413835430263483 1977 24207262 SGTC_1880 MG-132 525 µM 0.216408117469571 0.406022957639869 no 1325 0.414334819680005 2012 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1 SGTC_1878 temozolomide 1 mM 0.215995748812145 0.406181355466649 no 1326 0.414495530655898 2068 5394 DNA alkylating agent. SGTC_1554 st069299 38.7 µM 0.215459188660069 0.406387480349705 no 1327 0.414704663770291 1971 24207999 SGTC_3076 9116187 49.47 µM 0.215355906043945 0.406427160366466 no 1328 0.414744922639688 2038 27241210 SGTC_140 0062-0056 502.533 µM 0.215113837554847 0.406520164115737 no 1329 0.414839282817445 1924 3758964 SGTC_164 4100-3994 89.624 µM 0.214456547312375 0.406772724425055 no 1330 0.415095524430526 2056 4615967 SGTC_2238 6671620 73.2395 µM 0.213991368694082 0.406951490296623 no 1331 0.415276894035079 1983 729941 SGTC_255 tunicamycin 200.472 nM 0.213335687167512 0.407203498421017 no 1332 0.41553256992603 2046 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_1328 1441-0025 69.2 µM 0.212214873974688 0.407634366635071 no 1333 0.415969701626019 1856 4562601 SGTC_1770 st043884 66.3 µM 0.21139919400362 0.407948004409289 no 1334 0.416287892812099 2002 670149 SGTC_1323 1348-1351 11.2 µM 0.211090941392159 0.408066546244677 no 1335 0.416408154348068 1890 6989654 SGTC_1307 1187-1599 12.2 µM 0.210774085610049 0.408188405291991 no 1336 0.416531780477334 1900 1538471 SGTC_182 3448-4371 550.524 µM 0.210387975232835 0.408336910853405 no 1337 0.416682438505689 2112 3491403 SGTC_1049 3226-0134 66 µM 0.209426273233049 0.408706857339432 no 1338 0.417057742204123 2014 5702385 SGTC_1092 toremifene 6.32 µM 0.208559348531588 0.409040414733457 no 1339 0.417396123909055 2059 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_2455 5377712 9.75 µM 0.20786068698889 0.409309279254449 no 1340 0.417668872965259 1847 2243908 SGTC_2366 9070441 60.58 µM 0.207854833306974 0.409311532095536 no 1341 0.41767115833973 1911 6837235 SGTC_1372 2752-0194 270 µM 0.207495492041874 0.409449833481502 no 1342 0.417811456449069 1944 823334 SGTC_2210 7115885 190.385 µM 0.206310787322703 0.409905876171923 no 1343 0.418274076362947 1957 2927039 SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM 0.205860123017448 0.410079387862118 no 1344 0.418450087730158 1931 5379071 SGTC_850 0388-0143 75.9 µM 0.205188037016252 0.410338182518852 no 1345 0.418712607839297 1930 67273 SGTC_1767 st044992 70.3 µM 0.204921697072573 0.410440750671519 no 1346 0.418816651558871 1906 9600693 SGTC_84 0443-0269 128.823 µM 0.20398637300547 0.41080099470394 no 1347 0.419182073895276 2034 6150058 SGTC_315 k915-0449 187 µM 0.203738173840287 0.410896602311845 no 1348 0.419279054699115 1987 20970215 YNL149C PGA2 SGTC_1291 0993-0025 5.79 µM 0.202929140605232 0.411208282839192 no 1349 0.419595208608629 2027 4353356 SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM 0.202805407135828 0.411255956177624 no 1350 0.419643565740336 1903 442882 SGTC_1701 st028638 40.4 µM 0.202786452595512 0.411263259298957 no 1351 0.419650973602343 2024 3490878 SGTC_3237 9133362 49.47 µM 0.202528350421262 0.411362708267385 no 1352 0.419751848587928 2039 43845137 SGTC_3046 9092212 49.47 µM 0.201568987733752 0.411732408772585 no 1353 0.420126845876137 2000 25236637 SGTC_2296 7971656 126.45 µM 0.201076689782227 0.41192215141538 no 1354 0.42031930429801 1916 666570 SGTC_294 k038-0071 157 µM 0.200662192732673 0.412081923821903 no 1355 0.420481362096139 1932 24152826 SGTC_3198 9112019 49.47 µM 0.200527282072929 0.412133929751491 no 1356 0.420534111639804 1959 45595555 SGTC_416 estradiol valerate 100 µM 0.200011572559874 0.412332741843079 no 1357 0.420735765201145 1953 13791 A steroid. SGTC_534 k292-0788 63.4 µM 0.199767712315147 0.412426760677414 no 1358 0.420831127072146 2093 4146317 SGTC_1637 st007924 17.4 µM 0.198809661111424 0.412796180097775 no 1359 0.421205819188185 1940 683336 SGTC_206 4546-0025 72.014 µM 0.197821322676054 0.413177359059996 no 1360 0.421592431377401 1953 6620745 YIL048W NEO1 SGTC_1100 amiodarone 5.07 µM 0.197625966697657 0.413252712981348 no 1361 0.421668858494571 2091 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. SGTC_2134 5324836 1.464 µM 0.197282548645526 0.41338518607035 no 1362 0.42180321757035 1985 699272 SGTC_867 0518-0118 155 µM 0.196523694996669 0.413677947875468 no 1363 0.422100144167864 2103 6848158 SGTC_2386 9075165 157.42 µM 0.196334880556998 0.413750798969957 no 1364 0.422174030951068 1987 16452277 SGTC_593 1203-0218 61.7 µM 0.195660451308383 0.414011041156105 no 1365 0.422437970654673 2069 3666956 SGTC_1026 k007-1105 30.6 µM 0.194363605599011 0.41451156137222 no 1366 0.422945592499985 1910 7066794 SGTC_796 1234-0020 70.7 µM 0.193942357049422 0.414674173013311 no 1367 0.423110508591478 2059 46495034 SGTC_772 k072-0172 35.3 µM 0.193813368578138 0.414723968459354 no 1368 0.423161009442283 1841 5861980 SGTC_845 0330-0138 4.51 µM 0.193040435255067 0.415022384734107 no 1369 0.42346365043096 2065 9039800 SGTC_1368 1852-0141 284 µM 0.191423854157569 0.415646677256092 no 1370 0.424096766347377 1968 2838987 SGTC_2938 9059746 27.26 µM 0.190843813723116 0.415870729712342 no 1371 0.424323980550295 2008 6471769 SGTC_2344 7990960 76.95 µM 0.189650326655117 0.416331824402542 no 1372 0.424791573918137 1939 140813 SGTC_622 1348-1566 26.3 µM 0.188806023092677 0.416658084282494 no 1373 0.425122425502145 2018 7340407 SGTC_546 peri-Naphthalide 147 µM 0.188666859069426 0.416711866237685 no 1374 0.425176963845646 2028 223824 A penicillin ester. SGTC_499 genistein 192 µM 0.188648701253268 0.416718883704095 no 1375 0.425184079994573 2093 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger. SGTC_1281 0884-0031 11.8 µM 0.188383308147855 0.41682145342721 no 1376 0.425288091806136 1937 1548255 SGTC_584 0986-0246 15.4 µM 0.187641514126142 0.417108173657471 no 1377 0.425578840330807 2086 53315 YDR232W HEM1 SGTC_3154 9100113 49.47 µM 0.186795500264291 0.41743523103157 no 1378 0.425910487545611 1933 25237525 SGTC_362 0310-0100 9.03 µM 0.186439880132288 0.417572725972303 no 1379 0.42604991040887 1964 790235 SGTC_1195 1502-0147 41.1 µM 0.185598722514046 0.417897986441498 no 1380 0.426379727723178 1959 817940 SGTC_184 1494-0393 24.714 µM 0.185593227820173 0.417900111325339 no 1381 0.426381882358338 1921 3090647 SGTC_3124 9127567 49.47 µM 0.185273872999824 0.418023614932258 no 1382 0.426507114786502 2085 17592030 SGTC_1911 st060208 74.3 µM 0.183684851324769 0.418638254838544 no 1383 0.427130346795009 2046 688783 SGTC_1811 st050069 61.5 µM 0.183413648113581 0.418743177209788 no 1384 0.427236733934159 2122 3877702 SGTC_1142 3253-1408 9.78 µM 0.183390671298336 0.418752066684188 no 1385 0.427245747483841 2103 256655 SGTC_1411 3909-8223 150 µM 0.181599394602223 0.419445219069971 no 1386 0.427948561993555 2084 X1411 SGTC_33 0986-0033 35.816 µM 0.181427164366407 0.419511878488411 no 1387 0.428016149293336 2082 2848082 SGTC_2220 6782180 200 µM 0.181381468886758 0.419529564702885 no 1388 0.428034081656584 2077 833803 SGTC_1793 st048256 72.231 µM 0.179678416156249 0.420188838660977 no 1389 0.428702519533598 2084 672022 SGTC_1601 4'-hydroxyflavanone 55.5 µM 0.178869605101871 0.420502018549927 no 1390 0.42902004473517 2077 165506 SGTC_2265 7929201 200 µM 0.177524154041563 0.421023102328878 no 1391 0.429548347177131 2069 1265108 SGTC_828 2074-0507 139 µM 0.176942477522474 0.421248424473291 no 1392 0.429776786382005 2085 X828 SGTC_405 ebelactone b 50 µM 0.176247939302604 0.421517499268977 no 1393 0.430049580047779 1971 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).  SGTC_2932 9016711 44.54 µM 0.176023441394339 0.421604481058043 no 1394 0.430137763203265 2117 7117328 SGTC_2979 9012552 45.46 µM 0.174613380130792 0.422150897064457 no 1395 0.430691717145025 2140 17100905 SGTC_1471 k673-0312 37 µM 0.174284873151342 0.422278219106653 no 1396 0.430820793392786 2100 24099884 SGTC_1653 st012112 65 µM 0.174025484320573 0.422378758221907 no 1397 0.430922717110092 2081 720429 SGTC_2140 5586273 200 µM 0.173657932115272 0.422521230122301 no 1398 0.4310671502001 2103 854421 SGTC_2641 levomentholum 100 µM 0.173481860144581 0.422589483361517 no 1399 0.431136342601273 2066 16666 SGTC_343 4130-2827 29.8 µM 0.172395939515778 0.423010485249446 no 1400 0.431563132093659 1946 1118244 SGTC_2458 5808907 16.39 µM 0.172004471707483 0.423162275469039 no 1401 0.431717006740695 2115 2731747 SGTC_2397 5161689 200 µM 0.171223795796804 0.423465013748101 no 1402 0.432023898722015 2050 2259942 SGTC_2990 9074105 71.4286 µM 0.168929156950394 0.424355112608681 no 1403 0.432926182422614 2079 6502001 SGTC_3304 9125678 46.087 µM 0.168900478434088 0.424366239562104 no 1404 0.432937461434468 1982 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2 SGTC_1939 st074455 53.6 µM 0.168185555572394 0.424643641341644 no 1405 0.433218652032143 2122 1644229 SGTC_3293 9120939 62.045 µM 0.167191270435231 0.425029502286394 no 1406 0.433609776463713 2046 934087 SGTC_2333 9017922 200 µM 0.166874376278507 0.425152497292091 no 1407 0.433734447593477 2099 3163164 SGTC_1985 st071382 65.5 µM 0.166463943268105 0.425311808028517 no 1408 0.433895928172368 2118 6123237 SGTC_1638 st008370 60.6 µM 0.164316451790295 0.426145561197177 no 1409 0.434741015532347 2093 24207134 SGTC_72 0744-0168 198.391 µM 0.163092616001026 0.426620857479762 no 1410 0.435222756767725 2006 677577 SGTC_3192 9110362 49.47 µM 0.162985707491045 0.426662382188095 no 1411 0.435264843982352 2076 16649480 SGTC_1033 k072-0102 21.3 µM 0.162675722839446 0.426782789004816 no 1412 0.435386881354545 2139 5965931 SGTC_1751 st044839 27.194 µM 0.16261306311747 0.426807128644554 no 1413 0.435411550510483 2138 5291326 SGTC_2264 7948757 110.76 µM 0.161644351517473 0.42718345188743 no 1414 0.435792964553073 1923 2971411 SGTC_246 cycloheximide 667 µM 0.161095615040962 0.427396653417949 no 1415 0.436009046914679 2024 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells. SGTC_1044 1222-0021 1.78 µM 0.160703128342196 0.427549159964156 no 1416 0.436163612700637 2047 4306703 SGTC_1634 st006576 41 µM 0.159731503746169 0.427926745684254 no 1417 0.436546291558438 2140 3915356 SGTC_2085 5307070 144.047 µM 0.159668509270202 0.42795122842392 no 1418 0.43657110427931 1982 2840351 SGTC_2501 sodium tetradecyl sulfate 13.37 µM 0.159401674377814 0.428054936611003 no 1419 0.436676209907547 1936 23665772 A membrane-active detergent. SGTC_1727 st034309 9.9045 µM 0.159347760240919 0.428075891511044 no 1420 0.436697447100731 2139 870305 SGTC_820 1582-0060 59.9 µM 0.158912560754142 0.428245048663671 no 1421 0.436868882201081 2002 3848840 SGTC_441 propafenone 146 µM 0.157944609628261 0.428621327628624 no 1422 0.437250222906945 2073 4932 Slows the influx of sodium ions into the cardiac muscle. SGTC_3072 9116419 49.47 µM 0.157107376121991 0.428946844096961 no 1423 0.437580112235663 2011 17170162 SGTC_1226 3909-7979 35.4 µM 0.157066947785843 0.428962563863034 no 1424 0.437596043033513 2111 6615510 SGTC_2112 5488546 200 µM 0.155675216101746 0.429503779987118 no 1425 0.438144516825357 2054 600757 SGTC_1670 st016595 4.04 µM 0.155182056173633 0.429695591698889 no 1426 0.438338897007996 2162 597879 SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM 0.15462091196979 0.429913865687153 no 1427 0.438560091449265 1981 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding. SGTC_895 0964-0006 13.7 µM 0.154331088070618 0.43002660984121 no 1428 0.438674343107115 2132 6738897 SGTC_1565 sinapyl alcohol 95.1 µM 0.154162147923822 0.430092331740174 no 1429 0.438740943464739 1989 5280507 A phenol propionate derived from cinnamic acid. SGTC_660 4031-1742 102 µM 0.154009566726141 0.43015169126772 no 1430 0.438801096213409 2019 6738706 SGTC_2286 7945697 125 µM 0.153113405751939 0.430500361669223 no 1431 0.439154422136078 1980 1245733 SGTC_3028 9087778 49.47 µM 0.152057537978228 0.430911238900914 no 1432 0.439570777235467 2071 17217395 SGTC_2546 rhodinyl acetate 100 µM 0.151253910627138 0.431224010196649 no 1433 0.43988771244898 2159 6708682 SGTC_301 4119-0100 24.5 µM 0.15040846062952 0.431553105397736 no 1434 0.440221183294424 2027 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1 SGTC_338 4055-0136 114 µM 0.150250951130913 0.431614421933594 no 1435 0.440283314459779 2091 2900563 SGTC_650 1328-0195 38 µM 0.148335806296577 0.432360095960209 no 1436 0.441038879291609 2162 2780821 SGTC_250 brefeldin a 552.239 µM 0.147622209910078 0.432638001096954 no 1437 0.441320463084821 2048 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.  SGTC_2449 5812982 45.77 µM 0.14744437081083 0.432707264486747 no 1438 0.441390642682281 2132 776185 SGTC_1437 4092-1038 11.6 µM 0.1469151805477 0.432913381618752 no 1439 0.441599484799198 2072 3977136 SGTC_1036 k216-0215 33.5 µM 0.146419005833551 0.433106655930631 no 1440 0.441795312256105 2063 622330 SGTC_783 0848-0141 92.7 µM 0.1455867915394 0.433430863221227 no 1441 0.442123797851747 2144 6755076 YHR007C | YLR033W ERG11 | RSC58 SGTC_1865 st057639 52.2 µM 0.14532396994956 0.433533260441848 no 1442 0.442227545165417 2163 688818 SGTC_3079 9117512 49.47 µM 0.144344554984239 0.433914886939903 no 1443 0.442614198441927 2166 7185044 SGTC_1791 st048313 56.1 µM 0.143978857220944 0.434057395939058 no 1444 0.442758582579741 2164 1204976 SGTC_1665 st014639 11.4 µM 0.140915085510482 0.435251654073596 no 1445 0.443968512276256 2157 981133 YIL048W NEO1 SGTC_351 caspofungin 25 nM 0.139950037375472 0.435627952694012 no 1446 0.444349733084913 2078 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1 SGTC_27 0485-0001 32.618 µM 0.139612074881193 0.435759747298008 no 1447 0.444483249845303 2153 2054479 SGTC_1961 st076550 68.7 µM 0.139293961243999 0.43588380799892 no 1448 0.444608930796102 2081 1579337 SGTC_881 0833-0569 170 µM 0.139002419724275 0.435997511417239 no 1449 0.444724118474506 1942 5418700 SGTC_394 menadione 8.33 µM 0.137434203986152 0.436609218054325 no 1450 0.445343798337671 2161 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_2917 7979103 53.79 µM 0.137234105300842 0.436687280557871 no 1451 0.445422876898684 2116 2980565 SGTC_2545 solidagenone 89.61 µM 0.13630866649547 0.437048344788944 no 1452 0.445788636479664 2154 6708572 An anti ulcer agent SGTC_3021 9087658 49.47 µM 0.13608457761882 0.437135781998844 no 1453 0.445877209690289 2170 25237042 SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM 0.134233875418336 0.437858024266037 no 1454 0.446608819797998 2060 279621 SGTC_2010 4012422 159 µM 0.13397131831404 0.437960504817147 no 1455 0.446712627307011 2118 952393 SGTC_1321 1326-2144 215 µM 0.133845408452504 0.438009651077071 no 1456 0.446762409731885 2167 3513030 SGTC_1082 camptothecin 424.86 nM 0.131744704155407 0.43882975719382 no 1457 0.447593112432399 2074 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_2830 7992007 71.43 µM 0.131670025195435 0.438858916401411 no 1458 0.447622647740834 2006 1952075 SGTC_2572 astragaloside iv 100 µM 0.130947316855896 0.43914112281014 no 1459 0.447908491738561 2050 45006101 An anti-inflammatory agent. SGTC_1438 4092-1045 4 µM 0.127684462097445 0.440415600104952 no 1460 0.449199343442267 2162 1351342 SGTC_3025 9087895 49.47 µM 0.127195417038279 0.440606675575043 no 1461 0.449392866297164 2187 17173641 SGTC_3010 9080089 71.4286 µM 0.125784355670934 0.441158070675831 no 1462 0.449951312886999 2185 17027233 SGTC_3002 9075603 71.4286 µM 0.124860985383049 0.441518954401474 no 1463 0.450316802872237 2201 20105405 SGTC_765 1319-0117 244 µM 0.124217141413039 0.441770618724094 no 1464 0.450571675233249 2205 3487746 YGL099W LSG1 SGTC_794 k038-0031 316 µM 0.12420107799712 0.441776897857957 no 1465 0.450578034365303 2180 6624242 SGTC_1051 3253-3903 78 µM 0.124061883962326 0.441831308938466 no 1466 0.450633138571304 2178 5509239 SGTC_307 1501-1223 22.3 µM 0.124010120808021 0.441851543484726 no 1467 0.450653630838214 2119 2830329 SGTC_802 4112-3352 742 µM 0.123510336017941 0.442046920335763 no 1468 0.450851495000343 2156 704594 SGTC_1640 st009078 66.4 µM 0.123302929701947 0.442128004162056 no 1469 0.450933610485747 2182 690618 SGTC_193 1273-0060 1.558 µM 0.122363271545977 0.442495386266608 no 1470 0.451305662471262 2175 2847393 YHR072W ERG7 SGTC_2094 5332512 191.667 µM 0.121900947366067 0.442676161269806 no 1471 0.45148873266746 2175 755774 SGTC_1743 st037606 46.3785 µM 0.121784518965975 0.442721688230703 no 1472 0.451534837378337 2113 590142 YLR208W | YDL195W SEC13 | SEC31 SGTC_1107 amlodipine 47 µM 0.121747655696754 0.44273610302102 no 1473 0.451549435073022 2145 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.  SGTC_1344 1488-0097 29.1 µM 0.120592380299492 0.443187893256615 no 1474 0.45200695221787 2117 747966 SGTC_2447 5741742 33.78 µM 0.118830582926551 0.443877016331545 no 1475 0.452704789336726 2150 1776504 SGTC_484 loperamide 105 µM 0.118141794863824 0.444146480497807 no 1476 0.452977653903927 2204 3955 An opioid-receptor agonist. SGTC_1559 coumarin 343 70.1 µM 0.117878996928169 0.44424929778303 no 1477 0.453081767614066 2162 108770 A hepatotoxic, DNA x-linker. SGTC_273 hydroxyurea 18.1 mM 0.117686080083707 0.444324777119911 no 1478 0.453158198305851 2183 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12 SGTC_1287 0971-0001 34.6 µM 0.117506524395827 0.444395030675583 no 1479 0.45322933707176 2120 4665869 SGTC_3036 9090181 49.47 µM 0.11693698134284 0.44461788353392 no 1480 0.453454996151065 2162 25236586 SGTC_2841 9004761 38.96 µM 0.116679308112613 0.444718712600506 no 1481 0.4535570939968 1995 2991039 SGTC_811 0416-0114 265 µM 0.115984690937063 0.444990538230998 no 1482 0.453832337383052 2064 6612453 SGTC_3062 9077494 49.47 µM 0.115880467987003 0.445031326196782 no 1483 0.453873637843139 2156 16459633 SGTC_1643 st009866 20.2 µM 0.11587831349443 0.445032169370088 no 1484 0.453874491609829 2195 3156273 YOR207C RET1 SGTC_1984 st072354 53.1 µM 0.115516110010234 0.445173923360432 no 1485 0.454018026006415 2102 5762938 SGTC_2653 dihydrofissinolide 100 µM 0.11539872984201 0.445219863427472 no 1486 0.454064542838462 2133 6857746 SGTC_3008 9078912 71.4286 µM 0.115115712675043 0.445330633268693 no 1487 0.454176702892653 2106 16648731 SGTC_2902 5787006 60.46 µM 0.113539892959058 0.445947469775157 no 1488 0.454801268769843 2121 591003 SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM 0.112661710937576 0.446291280902535 no 1489 0.45514937908436 2097 689007 SGTC_497 capsazepine 133 µM 0.112242499431463 0.446455417830624 no 1490 0.455315566190995 2132 2733484 A calcium channel blocker. SGTC_2580 diallyl disulphide 81.36 µM 0.112076830881826 0.446520285772824 no 1491 0.455381243971617 2112 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.  SGTC_2312 7706453 155.7 µM 0.1118313754872 0.446616397087628 no 1492 0.45547855475824 2110 976098 SGTC_548 1436-0017 110 µM 0.110499072623416 0.447138132504041 no 1493 0.456006792653108 2207 9677137 SGTC_966 1300-0360 30.2 µM 0.108172820486232 0.448049321464723 no 1494 0.45692930226577 2126 70588 SGTC_557 1315-0110 16.2 µM 0.107299525430331 0.448391460679769 no 1495 0.457275680510879 2213 6833801 SGTC_2862 9027634 71.43 µM 0.107223332575077 0.448421313313011 no 1496 0.457305902707888 2158 5012562 SGTC_1584 6-fluoro-dl-tryptophan 90 µM 0.106319007177736 0.4487756534976 no 1497 0.457664625757129 2200 94937 An inhibitor of serotonin biosynthesis. SGTC_711 k292-0785 179 µM 0.105904342131327 0.448938144634376 no 1498 0.457829124461369 2187 4146315 SGTC_3070 9117005 49.47 µM 0.105898744070092 0.448940338355945 no 1499 0.45783134527633 2226 8779016 SGTC_190 3970-0790 3.722 µM 0.104676224023741 0.449419446597229 no 1500 0.458316364388701 2226 2832352 SGTC_949 1165-0505 146 µM 0.103666992506059 0.449815022208502 no 1501 0.458716810822591 2124 6244267 SGTC_2162 5663267 200 µM 0.103650870161057 0.44982134188429 no 1502 0.45872320824447 2204 6456493 SGTC_111 0083-0039 52.457 µM 0.103405812808356 0.449917401623998 no 1503 0.458820449463083 2232 759313 SGTC_387 norethindrone acetate 66.7 µM 0.102431559181879 0.450299327112449 no 1504 0.459207067401533 2120 541197 SGTC_2229 7354935 190 µM 0.102274032607577 0.450361084783227 no 1505 0.459269583092964 2223 318112 SGTC_2464 5717415 7.67 µM 0.101969025786476 0.450480664917225 no 1506 0.459390630371407 2181 5285744 SGTC_1259 0671-0132 43 µM 0.101937951266311 0.450492848160504 no 1507 0.459402963048402 2128 X1259 SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM 0.10186891559657 0.450519914822904 no 1508 0.459430361668083 2252 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis. SGTC_2826 7992541 19.48 µM 0.100874015939138 0.450910008425088 no 1509 0.459825235074801 2248 2985066 SGTC_1228 0124-0032 52.5 µM 0.0980696453027445 0.452009837681999 no 1510 0.460938495423994 2188 X1228 SGTC_2052 5265182 7.135 µM 0.0966363885180817 0.452572080828523 no 1511 0.461507578930003 2208 1239884 SGTC_1331 1472-0049 76.2 µM 0.0959856554186235 0.452827384220925 no 1512 0.461765982636416 2221 24051409 SGTC_582 0987-0078 156 µM 0.0955797347600132 0.452986649752091 no 1513 0.461927180409605 2244 1625765 SGTC_2470 5664817 21.68 µM 0.0951200580395003 0.453167015943789 no 1514 0.462109733149614 2266 2859561 SGTC_1924 st058459 75.1 µM 0.0942446380854937 0.453510536564885 no 1515 0.462457413241325 2265 688683 SGTC_209 4077-0173 175.592 µM 0.0937934697275189 0.453687591634373 no 1516 0.462636609610003 2190 15993494 SGTC_82 0054-0107 293.755 µM 0.0936757308383846 0.45373379822398 no 1517 0.462683374735677 2242 3104697 SGTC_3035 9091303 49.47 µM 0.092881878940436 0.454045361464952 no 1518 0.462998701008775 2239 25237002 SGTC_2683 piperine 63.03 µM 0.0927662120343979 0.454090759647805 no 1519 0.463044647058462 2177 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_670 4204-0025 119 µM 0.0925742704910063 0.454166096238344 no 1520 0.463120892561915 2195 719039 SGTC_1283 0922-0125 16.4 µM 0.092118212114698 0.454345104654507 no 1521 0.463302059399913 2213 3360884 SGTC_2461 5755302 26.15 µM 0.0910446794147921 0.454766515736796 no 1522 0.463728544707035 2244 2788904 SGTC_2801 7907800 81.82 µM 0.0905119027509009 0.454975674075606 no 1523 0.463940217875152 2140 6620925 SGTC_2320 7373003 200 µM 0.0902952613258969 0.455060727095595 no 1524 0.46402629284238 2155 5415828 SGTC_1075 aripiprazole 15.2 µM 0.0901454928638346 0.455119527119475 no 1525 0.46408579913843 2203 60795 An atypical antipschotic. YIL048W NEO1 SGTC_397 arbidol 50 µM 0.0900612910920078 0.455152585687409 no 1526 0.464119254702746 2236 131410 A RNA synthesis inhibitor. SGTC_2733 amorolfine 100 µM 0.0895240413769469 0.455363523304844 no 1527 0.46433272401772 2258 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_1839 st053978 48 µM 0.0894525269171258 0.455391602613084 no 1528 0.464361140150929 2258 3788398 SGTC_3100 9120536 49.47 µM 0.0893356091648379 0.455437509467928 no 1529 0.464407597586635 2275 16421196 SGTC_568 1193-0097 7.48 µM 0.0892898590197112 0.455455473072015 no 1530 0.464425776604207 2223 3646150 SGTC_873 0591-4978 488 µM 0.0891555349057744 0.455508215402435 no 1531 0.464479151299429 2238 3305145 SGTC_2082 5219693 150 µM 0.0888278490653529 0.455636884455332 no 1532 0.464609362408276 2233 2834649 SGTC_2552 juarezic acid 87.02 µM 0.0884929398728829 0.455768394636302 no 1533 0.464742447745697 2268 1549512 SGTC_2906 7926292 26.41 µM 0.0869517487684109 0.456373642781838 no 1534 0.465354932838999 2154 2966319 SGTC_251 melphalan 456.522 µM 0.0857964984244882 0.45682739284265 no 1535 0.465814095034361 2185 460612 A DNA alkylator. SGTC_2617 dihydrotanshinone i 20.83 µM 0.0849795785313428 0.457148290168716 no 1536 0.466138812971795 2212 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12 SGTC_324 1315-0088 19.6 µM 0.0838591438738477 0.457588457654734 no 1537 0.466584211778934 2247 6787421 SGTC_2050 5263056 171 µM 0.0821793507224921 0.458248468792074 no 1538 0.467252046816272 2250 763468 YGL055W OLE1 SGTC_2964 9083345 53.42 µM 0.0820312692606329 0.458306657346133 no 1539 0.467310923983671 2177 17741579 SGTC_2009 4012297 12.05 µM 0.0815419172240535 0.458498954390993 no 1540 0.467505495361164 2152 45595307 SGTC_591 4299-0174 154 µM 0.0813380061702937 0.458579086676773 no 1541 0.467586574777195 2207 5509088 SGTC_279 1273-0055 2.93 µM 0.0811122536430526 0.4586678041152 no 1542 0.467676340400759 2258 2847562 SGTC_2399 5884133 200 µM 0.0808330917648077 0.458777513493276 no 1543 0.467787345373418 2185 722445 SGTC_2091 4-phenylthiadiazole 200 µM 0.0801571541940492 0.459043166945249 no 1544 0.468056133231364 2213 270010 SGTC_1363 1636-0063 10.4 µM 0.0784204275920421 0.459725809747988 no 1545 0.468746812349629 2242 6072185 SGTC_2212 7123476 200 µM 0.0783224707563645 0.459764316502877 no 1546 0.468785771643485 2219 1085715 SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM 0.0778758142272565 0.459939901610935 no 1547 0.468963419210768 2239 23847180 SGTC_130 0136-0219 337.655 µM 0.0744668158702567 0.461280267544283 no 1548 0.470319472465249 2297 234244 SGTC_396 dithiazanine 1.25 µM 0.0740462625114916 0.461445653476801 no 1549 0.470486787054386 2142 10578 An antihelmenthic. SGTC_2097 5376186 200 µM 0.0732836418340856 0.46174557707498 no 1550 0.47079020431063 2261 742755 SGTC_1485 3909-9022 254 µM 0.0720688600943116 0.462223371517873 no 1551 0.471273553904416 2258 714516 SGTC_1124 fisetin 1.16336 µM 0.0692538289148977 0.46333077983449 no 1552 0.472393788320135 2129 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster. SGTC_454 lyso-paf C-16 6.67 µM 0.0683522846954321 0.463685499838057 no 1553 0.47275260212165 2198 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_1680 diphenhydramine 100 µM 0.0682742198681423 0.463716216450011 no 1554 0.472783672898208 2130 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1 SGTC_2972 9093619 59.92 µM 0.0679374301899831 0.463848737478903 no 1555 0.472917721293748 2219 25236256 SGTC_1423 4048-0112 5.59 µM 0.0676549752413499 0.46395988180612 no 1556 0.473030145847678 2291 X1423 SGTC_24 0417-1663 219 µM 0.0655527999139742 0.464787162965161 no 1557 0.473866934223768 2213 4329390 SGTC_2739 tacrine 100.86 µM 0.0638897035780557 0.46544175887987 no 1558 0.474529025441995 2240 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders. SGTC_2737 bleomycin 30.5 nM 0.0632035196760995 0.465711868711985 no 1559 0.474802221044627 2286 16211318 Bleomycin acts by induction of DNA strand breaks. SGTC_2341 7987486 176.74 µM 0.0622220749724685 0.466098232603128 no 1560 0.475192991631262 2285 1258686 SGTC_1722 st034304 3.6505 µM 0.0621200221953608 0.466138409409894 no 1561 0.475233626191781 2249 4036148 YLR033W RSC58 SGTC_361 000s-0510 1.45 µM 0.0606756407788366 0.4667070797751 no 1562 0.475808765885439 2237 660 SGTC_2769 toremifene 3.73 µM 0.0603951368829515 0.466817525456245 no 1563 0.475920465897139 2262 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_1508 1080-0625 72.9 µM 0.0596800422476125 0.46709909855456 no 1564 0.476205233688365 2293 767111 SGTC_1531 st059297 52.4 µM 0.0595525287632726 0.467149309540545 no 1565 0.476256013889334 2267 7566702 SGTC_2086 5274770 176.623 µM 0.0594765223429748 0.467179238838127 no 1566 0.476286282411239 2240 689278 SGTC_1497 4476-2978 41.3 µM 0.0587736936657973 0.46745600276245 no 1567 0.476566180821475 2256 1528379 SGTC_617 3770-0098 35 µM 0.0587175488011957 0.467478112490982 no 1568 0.476588540765862 2234 5962639 SGTC_757 1066-0008 322 µM 0.0580904796549698 0.46772505779266 no 1569 0.47683827886159 2274 6842497 SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM 0.057624364499243 0.467908626061719 no 1570 0.477023920926224 2253 5393153 SGTC_2291 7917025 104.35 µM 0.0557835715107346 0.468633644526925 no 1571 0.477757111299282 2280 2964612 SGTC_1540 guanosine 70.6 µM 0.0551030255830755 0.468901712197497 no 1572 0.478028192871138 2303 6802 Guanosine is a purine nucleoside SGTC_1126 isoteolin 1.0172 µM 0.0550805066205493 0.468910582679323 no 1573 0.478037163014413 2306 133323 SGTC_1528 arabinosylhypoxanthine 74.6 µM 0.054190187907545 0.469261301919947 no 1574 0.478391819057258 2288 804 An inhibitor of viral and cellular DNA polymerases. SGTC_195 4234-0266 16.654 µM 0.0533644948632096 0.469586584786223 no 1575 0.47872074693978 2222 2303354 SGTC_2593 nobiletin 86.24 µM 0.0519226663410607 0.470154643581325 no 1576 0.479295156752618 2250 72344 An anti-infammatory. SGTC_491 tetrandrine 80.3 µM 0.0508378195297372 0.470582097050866 no 1577 0.479727377099958 2292 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_104 0074-0074 590.992 µM 0.0502965814130052 0.47079536946135 no 1578 0.479943023980493 2336 3943124 SGTC_1111 tnp00062 510.699 nM 0.0496500726106115 0.471050134279065 no 1579 0.480200621817194 2310 676306 SGTC_695 3505-6186 243 µM 0.0491568558896232 0.471244500422356 no 1580 0.480397146842671 2279 1819379 SGTC_890 0929-0006 47.2 µM 0.048989414288505 0.471310487129868 no 1581 0.480463865992779 2277 1378169 SGTC_100 0086-0128 49.5915 µM 0.0489444678724692 0.471328200102351 no 1582 0.480481775534208 2291 93297 SGTC_2271 7849410 118.62 µM 0.0481955726514346 0.471623341194948 no 1583 0.480780189300803 2340 972430 SGTC_859 0439-0102 54.6 µM 0.0481143171308526 0.471655365096918 no 1584 0.480812568000236 2324 610143 SGTC_2448 5185112 27.17 µM 0.0472312952437749 0.472003387763912 no 1585 0.481164442674659 2255 5718189 SGTC_3122 9126309 49.47 µM 0.0468301979719148 0.472161478059267 no 1586 0.481324280464207 2327 17591206 SGTC_2478 5763493 32.33 µM 0.0444286399431632 0.473108129901643 no 1587 0.482281366404705 2293 1365576 YLR208W SEC13 SGTC_2404 5161160 200 µM 0.0429439970555579 0.473693426277473 no 1588 0.482873088251161 2309 2831543 SGTC_1608 st001473 40.5 µM 0.0412639038445435 0.474355844206975 no 1589 0.483542754553212 2275 7292267 SGTC_1409 3909-8004 61.9 µM 0.0407755599515342 0.474548399137725 no 1590 0.483737411741784 2282 2119279 SGTC_1726 st035556 14.5795 µM 0.0407633912202281 0.474553197367856 no 1591 0.483742262330322 2304 5919439 SGTC_614 0462-0418 107 µM 0.0403836403613134 0.474702938084221 no 1592 0.48389363635503 2306 5188303 SGTC_2945 9067681 61.76 µM 0.0396324426058622 0.474999155662315 no 1593 0.484193081145501 2346 16456930 SGTC_3313 9133968 57.047 µM 0.0381074492024629 0.475600544112074 no 1594 0.484801006010537 2334 1494643 SGTC_1760 st045453 10.4495 µM 0.0378932431717443 0.475685021769758 no 1595 0.484886400174771 2330 3323419 YIL048W NEO1 SGTC_929 2805-0021 398 µM 0.0375802865739145 0.475808446217409 no 1596 0.485011162926398 2225 3098024 SGTC_54 0159-0055 9 µM 0.0372690796996784 0.475931182907408 no 1597 0.485135229591238 2342 3319099 SGTC_23 0213-0011 39.996 µM 0.0364645964236421 0.476248473131559 no 1598 0.485455953942749 2326 627608 SGTC_3310 9130229 44.1445 µM 0.0351735614225272 0.476757691970607 no 1599 0.485970672055195 2326 7761258 SGTC_1810 st050138 53 µM 0.0338331308106251 0.477286433914945 no 1600 0.486505108247506 2354 3444541 SGTC_2785 7756463 72.73 µM 0.0313929590876999 0.478249078202492 no 1601 0.487478078109765 2335 2201551 SGTC_764 1951-2361 146 µM 0.0312148095320224 0.478319362988676 no 1602 0.487549114685589 2337 5438930 SGTC_73 0327-0325 16.231 µM 0.0311094305460155 0.478360938147472 no 1603 0.487591134411389 2352 53298 SGTC_3029 9088683 49.47 µM 0.0307490158545617 0.478503134289918 no 1604 0.487734850312542 2313 25236615 SGTC_1794 st048918 76.9 µM 0.0306290761970399 0.478550455267845 no 1605 0.487782676785786 2346 672303 SGTC_1270 0831-1170 17.3 µM 0.0303589515802659 0.478657031307722 no 1606 0.487890390823596 2346 6764716 SGTC_201 4262-0159 12.803 µM 0.02878516287558 0.479277990261914 no 1607 0.488517967143766 2349 1341029 SGTC_2170 morpholine 200 µM 0.0281831709939433 0.479515527427941 no 1608 0.488758029747301 2319 121171 Reacts with secondary amines. SGTC_1518 st038567 90.8 µM 0.0267288139639273 0.48008942523375 no 1609 0.489338015559281 2360 77966 SGTC_2129 girgensonine 121.053 µM 0.0267003816959902 0.480100645188488 no 1610 0.489349354346291 2329 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_1544 7-methoxy-4-methylcoumarin 105 µM 0.0238889704679199 0.481210162014391 no 1611 0.490470586032654 2361 390807 SGTC_3346 9158254 43.5805 µM 0.0237460911692651 0.481266552952926 no 1612 0.490527570460627 2326 17639500 SGTC_1948 st076329 66.6 µM 0.0227585667083293 0.481656314712419 no 1613 0.490921429216667 2371 24208413 SGTC_2627 acetyl isogambogic acid 100 µM 0.0224596015804937 0.481774315440857 no 1614 0.491040668566357 2334 6857789 A caspase activator and apoptosis inducer. SGTC_1710 st031758 61.5 µM 0.0217660183513947 0.482048076999747 no 1615 0.491317300594349 2365 5394341 SGTC_158 k038-0087 26.446 µM 0.0211585267157004 0.482287864636795 no 1616 0.49155959887784 2314 X158 SGTC_1361 1608-0041 5.61 µM 0.0198932532100045 0.482787310821282 no 1617 0.492064263619984 2363 X1361 SGTC_721 1187-1332 279 µM 0.0197199505905242 0.482855721338968 no 1618 0.492133387802023 2357 25730 SGTC_1465 k213-0056 144 µM 0.0196352592825463 0.482889153078667 no 1619 0.492167168204891 2334 24048857 YMR208W ERG12 SGTC_89 0302-0250 142.109 µM 0.0190086685606037 0.483136502348149 no 1620 0.492417095074304 2365 4203518 YLR208W SEC13 SGTC_3208 9114115 49.47 µM 0.0181982937944373 0.483456410737873 no 1621 0.49274033188338 2333 650895 SGTC_3335 9143315 29.6265 µM 0.0176056471291289 0.483690374234555 no 1622 0.492976725809189 2346 4899691 SGTC_701 4424-0219 185 µM 0.0173293685763833 0.483799444681343 no 1623 0.493086928191279 2374 2911779 SGTC_1117 retinoic acid 1.10837 µM 0.0167534937210541 0.484026794944962 no 1624 0.493316635658979 2368 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR). SGTC_1367 1812-0510 76.9 µM 0.0153642772889893 0.484575266450508 no 1625 0.493870781327491 2368 1142582 YDR527W RBA50 SGTC_1929 genistein trimethyl ether 50.5 µM 0.01503721742553 0.484704396052789 no 1626 0.494001244261235 2392 136420 SGTC_1149 3909-7961 23.3 µM 0.014851451704427 0.484777740691694 no 1627 0.494075345786401 2344 735261 SGTC_541 4513-1321 94 µM 0.0142246960967212 0.485025202207688 no 1628 0.494325358671495 2359 747515 SGTC_744 1594-0068 283 µM 0.0137835572176124 0.485199380253217 no 1629 0.494501330364234 2367 668392 SGTC_925 2064-1272 59.6 µM 0.0128096921418132 0.48558390837651 no 1630 0.494889811959691 2367 6815817 SGTC_1324 1418-0026 34.4 µM 0.0114520981042529 0.486119973185271 no 1631 0.495431373730102 2326 1372513 SGTC_1687 st020778 55.3625 µM 0.0111696311088929 0.486231512375088 no 1632 0.495544054548817 2374 4259299 SGTC_1792 st045773 43.6 µM 0.0109638665555258 0.486312764357221 no 1633 0.495626137702182 2377 2919270 SGTC_1477 0139-0234 16 µM 0.00981876297911998 0.486764951336704 no 1634 0.496082943245827 2384 620880 SGTC_2416 tofa 880 nM 0.00981524361563899 0.486766341115543 no 1635 0.496084347201066 2372 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_1773 st048542 73.5835 µM 0.00966785949119907 0.486824542504966 no 1636 0.496143142169888 2371 3237138 SGTC_1915 st067105 30.6 µM 0.00611194695036399 0.488228840027146 no 1637 0.497561701126745 2394 69751 YOR207C | YOR116C RET1 | RPO31 SGTC_795 0685-0265 78 µM 0.0037111320736411 0.48917705110607 no 1638 0.498519475906092 2401 302754 SGTC_2156 5649887 115 µM 0.00294993658586112 0.489477701222165 no 1639 0.498823147278251 2397 54680440 YKL052C | YBR257W ASK1 | POP4 SGTC_1988 st071872 53.4 µM 0.00191305177500745 0.489887250202207 no 1640 0.499236803227873 2404 16414116 SGTC_518 1021-0119 62.6 µM 0.00180395224670502 0.489930342984228 no 1641 0.499280327567296 2400 1097762 SGTC_2645 abamectin 100 µM -3.09314097218372e-05 0.4906551134834 no 1642 0.499987660152871 2402 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels. SGTC_951 1171-0579 82.7 µM -0.000152406109525935 0.49070309653937 no 1643 0.499939198759354 2400 1616050 YPR165W | YDR526C RHO1 | YDR526C SGTC_1730 st033808 45.1 µM -0.000882874375705486 0.490991637621687 no 1644 0.499647784129005 2409 1045166 SGTC_2110 5483698 200 µM -0.0010155776695751 0.491044057044475 no 1645 0.499594843198221 2406 2848765 YHR062C RPP1 SGTC_160 3453-0671 289.699 µM -0.00128710362859915 0.491151313597531 no 1646 0.499486520085069 2409 5322268 SGTC_1250 0485-0349 40.2 µM -0.00196558379992718 0.4914193255385 no 1647 0.499215846021469 2414 6842794 YDL195W SEC31 SGTC_1269 0831-0796 3.05 µM -0.00238904247029951 0.491586601344512 no 1648 0.499046910855553 2414 927758 SGTC_2981 9013952 38.96 µM -0.00368251275496881 0.492097560563493 no 1649 0.498530893284328 2419 2996344 SGTC_2615 purpurogallin-4-carboxylic acid 100 µM -0.00381765674721487 0.492150947221053 no 1650 0.498476979011023 2411 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase. SGTC_3056 9094900 49.47 µM -0.0038261023951137 0.49215428355541 no 1651 0.498473609709598 2417 25236784 SGTC_2911 7942208 15.64 µM -0.00434704202182756 0.492360074476264 no 1652 0.498265786604653 2422 1243384 SGTC_808 0711-0032 135 µM -0.0056534169468985 0.492876150967663 no 1653 0.497744624965204 2412 4252555 SGTC_1974 st069448 26.9 µM -0.00610022550865922 0.49305266310231 no 1654 0.497566377218255 2417 6323587 YNR016C ACC1 SGTC_2454 5-benzylidenerhodanine 10.36 µM -0.00630438278100788 0.493133316076014 no 1655 0.497484931817165 2424 1273210 SGTC_2476 5806916 10.51 µM -0.0094305199526252 0.494368339509288 no 1656 0.496237822629501 2428 2870194 SGTC_2076 5212012 200 µM -0.0102931088006682 0.494709127088422 no 1657 0.495893716211589 2419 604802 SGTC_356 1634-0012 32.5 µM -0.0111894592767752 0.495063257141603 no 1658 0.495536144748613 2425 735457 SGTC_348 k064-0012 10.7 µM -0.0115805722140265 0.495217779235857 no 1659 0.495380123374489 2425 5066323 SGTC_1325 1431-0015 227 µM -0.0116803487479504 0.49525719936953 no 1660 0.495340320988609 2422 1103340 SGTC_1210 3013-0140 750 nM -0.0119087108854905 0.495347421819259 no 1661 0.495249224013412 2430 905973 SGTC_424 splitomicin 100 mM -0.0146780272340838 0.496441554683176 no 1662 0.494144524599174 2466 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_2999 9069765 71.4286 µM -0.0146967860354191 0.496448966223406 no 1663 0.494137041727338 2439 2097066 SGTC_3109 9122853 49.47 µM -0.0149106599995344 0.496533467203743 no 1664 0.494051727709342 2473 1234709 SGTC_175 3793-3120 23.7 µM -0.0161279960050857 0.497014435963289 no 1665 0.493566139417633 2441 5322297 SGTC_2803 7707263 71.43 µM -0.0163277124376969 0.497093344244578 no 1666 0.493486474578995 2445 2199229 SGTC_950 1165-0508 94.1 µM -0.0171770891072444 0.497428935555259 no 1667 0.493147669868618 2445 6148369 SGTC_1010 4112-3296 15.2 µM -0.0174047315991218 0.497518878116558 no 1668 0.493056867228889 2435 704384 SGTC_3219 9131112 49.47 µM -0.0183468371824722 0.497891109514006 no 1669 0.492681081537749 2439 17612988 YMR079W SEC14 SGTC_994 3910-0338 138 µM -0.0184323155821052 0.497924882622749 no 1670 0.492646986355667 2462 3479481 SGTC_2262 9014885 67.46 µM -0.0187466010615602 0.498049059122201 no 1671 0.492521626252401 2473 6457424 SGTC_2626 ethyl orsellinate 100 µM -0.0203537751734404 0.498684068105637 no 1672 0.491880579135155 2455 75653 A natural product. SGTC_1742 st038235 28.8875 µM -0.020960898841419 0.498923949095741 no 1673 0.491638423510795 2477 564103 YBR002C RER2 SGTC_1995 st072814 61.1 µM -0.0216598297240325 0.499200104564834 no 1674 0.491359653742586 2456 5769371 SGTC_2206 7254556 146.969 µM -0.0232985428810376 0.499847579872727 no 1675 0.490706067005986 2442 4398905 SGTC_2918 7977171 22.06 µM -0.02344386360666 0.499904997886309 no 1676 0.490648108255445 2445 2236483 SGTC_1155 4088-0394 48.2 µM -0.0236107480434003 0.499970935990848 no 1677 0.490581549421607 2448 2326248 SGTC_3314 9135860 59.4275 µM -0.0236788133639182 0.499997829440965 no 1678 0.490554402876976 2446 25252478 SGTC_2503 beta-caryophyllene alcohol 24.72 µM -0.023689800410624 0.499997829440965 no 1679 0.490550020908705 2520 61125 An anti-inflammatory. SGTC_1377 2944-0135 198 µM -0.0239477386926675 0.499895914836068 no 1680 0.490447147608437 2461 1894137 SGTC_719 2810-4230 27.3 µM -0.0255308207347775 0.499270419943106 no 1681 0.489815782551766 2443 721079 SGTC_2687 chenodiol 100 µM -0.0258546212862341 0.49914248259328 no 1682 0.489686647451039 2459 5702181 A cholesterol synthesis inhibitor. SGTC_410 α-linolenic acid 100 µM -0.027038935197746 0.498674547294386 no 1683 0.489214339788513 2543 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_1568 digitonin 820 nM -0.0276700696071514 0.498425179933244 no 1684 0.488962647776418 2460 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1 SGTC_2329 6138490 200 µM -0.0284181349211546 0.49812961283583 no 1685 0.48866433023333 2591 720019 SGTC_3078 9116413 49.47 µM -0.0294467168871079 0.497723212884296 no 1686 0.488254157127191 2459 17177322 SGTC_2788 5282734 71.43 µM -0.030529460759417 0.497295415744186 no 1687 0.487822399019312 2491 743706 SGTC_1856 st057054 55.7 µM -0.0321136960457818 0.496669482754988 no 1688 0.487190690589537 2483 1266018 SGTC_3101 9120531 49.47 µM -0.0330551664168987 0.496297510629454 no 1689 0.486815297605358 2460 24824904 SGTC_2840 9008771 71.43 µM -0.0336421191639929 0.496065608964449 no 1690 0.486581267513665 2508 2992978 SGTC_503 tyrphostin 8 294 µM -0.0336810265792281 0.496050236913894 no 1691 0.486565754492112 2463 92970 A tyrosine kinase inhibitor. YOR207C RET1 SGTC_1112 tnp00069 1.16933 µM -0.0340843731705538 0.495890877816198 no 1692 0.486404934824259 2558 145826 SGTC_1837 st055472 66.5 µM -0.0350608168365725 0.495505095291498 no 1693 0.486015622911769 2568 676091 SGTC_132 0417-1715 25.805 µM -0.0352153370716792 0.495444046363242 no 1694 0.485954016300972 2474 6769098 SGTC_1816 st051957 91.6 µM -0.0354338547145448 0.495357713076878 no 1695 0.48586689474767 2461 674121 SGTC_1024 4507-0395 26 µM -0.0358396277133534 0.495197398379399 no 1696 0.485705117502647 2603 4201836 SGTC_1895 st058434 18.3 µM -0.0358774855449615 0.495182441369076 no 1697 0.485690024119903 2464 5393175 SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM -0.0364227928026591 0.494967000148641 no 1698 0.485472620103435 2477 364106 SGTC_2541 muurolladie-3-one 83.07 µM -0.0381994834315116 0.494265071721414 no 1699 0.484764316379369 2599 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils.  YMR203W TOM40 SGTC_990 3985-0011 41.3 µM -0.0389645016094187 0.493962836482964 no 1700 0.484459345360226 2521 5399565 YGL099W LSG1 SGTC_2258 7960471 200 µM -0.0391359550337245 0.49389510095835 no 1701 0.484390997472648 2522 2974708 SGTC_346 4513-0042 7.16 µM -0.039728639937768 0.493660952305556 no 1702 0.484154734163975 2482 2827372 SGTC_1201 1889-3372 45.9 µM -0.0412969054623082 0.49304139731654 no 1703 0.483529600025471 2526 5392199 SGTC_2046 4110841 106 µM -0.0419737623807809 0.492774005042233 no 1704 0.483259807132556 2491 44119630 YMR134W ERG29 SGTC_2616 abietic acid 100 µM -0.0425061330284893 0.492563694333428 no 1705 0.483047611360554 2488 6708678 Abietic acid is an inhibitor of 5α-reductase. SGTC_2305 7443522 69.23 µM -0.0447352737981136 0.491683105090695 no 1706 0.482159158703219 2513 5415886 SGTC_1447 4239-0816 81.9 µM -0.04499560412198 0.491580267989718 no 1707 0.482055406404912 2494 1341554 SGTC_528 3492-0019 172 µM -0.0451005669160667 0.491538805173624 no 1708 0.482013574775132 2486 2869262 SGTC_2977 9011197 71.43 µM -0.0454026004136025 0.49141949522411 no 1709 0.481893204148254 2620 2704722 SGTC_781 4335-2806 94.4 µM -0.0459651442364131 0.491197279956316 no 1710 0.481669015700272 2614 845254 SGTC_1828 st055811 49 µM -0.0462369513904953 0.491089912052177 no 1711 0.481560695502723 2481 5877589 SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM -0.0472576538452023 0.49068672509554 no 1712 0.481153938843129 2478 66535 A nucleotide analog. SGTC_2338 7999974 200 µM -0.0473835146323966 0.490637009565464 no 1713 0.481103783839641 2556 315925 SGTC_85 0868-0259 160.055 µM -0.0474945122114851 0.490593165184576 no 1714 0.481059552011335 2566 83173 SGTC_1473 k844-0725 134 µM -0.0483331842166954 0.49026189090634 no 1715 0.480725354134296 2480 54682906 SGTC_2260 7964312 200 µM -0.0487174057431411 0.490110126166419 no 1716 0.480572252284239 2629 231951 SGTC_3211 9128781 49.47 µM -0.0492100451607503 0.489915539237018 no 1717 0.480375953043092 2597 17194361 SGTC_1207 2099-0101 141 µM -0.0495474828055542 0.489782256613105 no 1718 0.480241498917392 2510 5837381 SGTC_322 k048-0136 19.3 µM -0.0517258163886932 0.488921876819577 no 1719 0.479373583133736 2568 6823282 SGTC_589 1227-0070 34.1 µM -0.0522617708490188 0.48871019780292 no 1720 0.479160057055193 2563 2841384 SGTC_899 1083-0020 478 µM -0.0524195571343988 0.488647879593296 no 1721 0.479097195599649 2611 767123 SGTC_2428 5615643 7.78 µM -0.0529733287165151 0.488429167898556 no 1722 0.478876579233883 2543 2253075 SGTC_252 miconazole 1.30953 nM -0.0539365448375902 0.488048754701017 no 1723 0.478492860229798 2505 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_1385 3091-4834 14.1 µM -0.0546933355217521 0.48774987490911 no 1724 0.478191389450177 2550 4072814 SGTC_576 1073-0113 22.7 µM -0.0552927042387829 0.487513170741435 no 1725 0.47795263722515 2507 5439563 SGTC_2941 9056145 11.23 µM -0.0565030928358197 0.487035174597027 no 1726 0.477470515868318 2500 2119517 SGTC_3132 9126706 49.47 µM -0.0568296868350516 0.486906202095566 no 1727 0.477340432735483 2648 850858 SGTC_1223 0764-0573 147 µM -0.0568879049623403 0.486883211805844 no 1728 0.4773172445761 2521 1609797 SGTC_1521 st012942 49.4 µM -0.0571645166484937 0.486773978679486 no 1729 0.477207071765678 2691 24207259 SGTC_1962 st076595 64.5 µM -0.0584277525048401 0.486275143360347 no 1730 0.476703954612538 2521 279619 SGTC_8 0354-0001 70 µM -0.0588385883563493 0.486112914245423 no 1731 0.476540336311555 2504 4993152 SGTC_1965 Pectolinarigenin 58.4 µM -0.0591832490648958 0.48597681786135 no 1732 0.476403075781764 2521 5320438 An anti-inflammatory. SGTC_53 0973-0023 39.979 µM -0.060663383021479 0.485392375229789 no 1733 0.475813647031604 2501 674768 SGTC_2181 6316240 54.2555 µM -0.0633963508971205 0.484313324573231 no 1734 0.474725446485173 2563 12779990 SGTC_292 k038-0015 474 µM -0.0637040905586165 0.484191827565668 no 1735 0.474602923785258 2583 46368540 SGTC_280 3448-3607 3.04 µM -0.0637319815204247 0.48418081616041 no 1736 0.474591819465949 2516 626179 SGTC_44 0929-0055 61.211 µM -0.064616087898058 0.483831775562371 no 1737 0.474239837594368 2529 1379590 SGTC_685 1278-0033 54.9 µM -0.0655648611672813 0.483457218601216 no 1738 0.473862132809109 2519 3590572 SGTC_3017 9080681 49.47 µM -0.06639760158091 0.483128481139815 no 1739 0.473530639826141 2588 16451914 SGTC_572 0960-0087 17.7 µM -0.0666942272926482 0.483011386202972 no 1740 0.473412565017162 2518 6796365 SGTC_2738 aclarubicin 5.55 µM -0.0667135542366707 0.483003756816341 no 1741 0.473404871816191 2596 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31 SGTC_392 N-ethylmaleimide 8.33 µM -0.0671334393025439 0.482838007087908 no 1742 0.473237736609891 2547 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides. SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM -0.0683157621556528 0.482371300891574 no 1743 0.472767138528147 2493 2333 A French combination drug. SGTC_2217 6934799 96.0675 µM -0.0686762763020105 0.482228997511189 no 1744 0.472623651188482 2538 675606 SGTC_1239 0337-0584 35.4 µM -0.068802483045563 0.482179181286597 no 1745 0.472573420794611 2600 914301 YML130C ERO1 SGTC_1245 0418-0076 17.2 µM -0.0696892904274719 0.481829149278548 no 1746 0.472220483029112 2611 6790114 SGTC_2688 kanamycin b 96.69 µM -0.0699776838113255 0.481715320444639 no 1747 0.472105710912278 2563 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis. SGTC_463 ikarugamyin 104 µM -0.070054795558004 0.481684884699692 no 1748 0.47207502308854 2530 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis. SGTC_1990 st072050 59.8 µM -0.0711195413323768 0.481264644143394 no 1749 0.471651307907891 2511 17233948 SGTC_3045 9092950 49.47 µM -0.0721635710024289 0.480852600161587 no 1750 0.471235867844155 2531 44120432 SGTC_1108 betulinic acid 729.144 nM -0.0732996576888483 0.480404247575859 no 1751 0.470783832046849 2549 64945 Apoptosis-inducing agent of unknown mechanism. SGTC_340 k038-0059 454 µM -0.07441419184392 0.479964424704697 no 1752 0.47034040832701 2519 23733424 SGTC_1941 st076221 61.8 µM -0.0745286102796326 0.479919273718455 no 1753 0.47029488837713 2643 2828568 SGTC_2205 7238770 200 µM -0.0745753494553867 0.479900829912687 no 1754 0.470276293889699 2610 279867 SGTC_2807 7945238 51.95 µM -0.0747860882366167 0.479817670548392 no 1755 0.470192455398607 2597 17148797 SGTC_2868 9035608 32.47 µM -0.0749168018407664 0.479766090259332 no 1756 0.470140454094424 2509 6462614 SGTC_2071 5230951 39.92 µM -0.0752978419373229 0.479615731730739 no 1757 0.469988869247213 2542 1799272 SGTC_1114 scopoletin 1.73284 µM -0.0785574444399754 0.478329612405923 no 1758 0.468692318649264 2535 5280460 A coumarin with genotoxic properties. SGTC_2639 lactacystin 53 µM -0.0794645677441938 0.477971734456026 no 1759 0.468331556652785 2597 3870 A proteasome inhibitor. SGTC_67 0335-0847 266 µM -0.0796870662198535 0.477883957141403 no 1760 0.468243073200027 2861 4552207 YOR254C SEC63 SGTC_1923 st058458 19.1 µM -0.0801445073805095 0.477703496553318 no 1761 0.468061162399945 2576 3534982 SGTC_1762 st045503 25.4615 µM -0.0806125718333431 0.477518849807765 no 1762 0.467875033934624 2595 4645554 SGTC_429 1112-0049 25.5 µM -0.0808021077583001 0.477444081151464 no 1763 0.467799665902187 2570 2836170 SGTC_2230 bromochlorosalicylanilide 954.5 nM -0.0810680744861311 0.477339163199855 no 1764 0.467693907482135 2541 77254 SGTC_1431 4049-0260 9.09 µM -0.0825715447591697 0.476746107402363 no 1765 0.467096113990252 2532 3854841 SGTC_2075 5212009 200 µM -0.0835099579902062 0.476375968866835 no 1766 0.466723029860191 2588 780898 SGTC_1510 1123-0200 71.5 µM -0.083749911903725 0.476281327051906 no 1767 0.466627636272683 2704 5378812 YNL149C | YNL150W PGA2 | YNL150W SGTC_1633 st005664 67.9 µM -0.0840329464251877 0.476169695248893 no 1768 0.466515118470392 2553 2063822 SGTC_381 3461-2219 42.7 µM -0.0848562499984667 0.475844986293203 no 1769 0.46618783686196 2593 2883159 SGTC_1146 3579-1023 7 µM -0.0849089143285584 0.475824216151225 no 1770 0.466166902387027 2671 X1146 SGTC_390 dec-rvkr-cmk 16.7 µM -0.0855266207806875 0.475580605501667 no 1771 0.465921366340591 2611 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1 SGTC_1304 1165-0502 251 µM -0.0857150033460572 0.475506313126131 no 1772 0.465846487539501 2593 767425 SGTC_1746 st038117 42 µM -0.0860487835725009 0.475374682411495 no 1773 0.465713818661595 2640 2898218 SGTC_3341 9147222 25.867 µM -0.086464043079309 0.475210923001935 no 1774 0.465548769229472 2644 1939759 SGTC_1202 1988-0068 29.6 µM -0.0865754352487965 0.475166995722036 no 1775 0.465504496200412 2582 2850480 SGTC_3038 9091290 49.47 µM -0.087416520978226 0.474835325023841 no 1776 0.465170218903197 2605 25236843 SGTC_1817 st052116 64.4 µM -0.0881936045913901 0.474528908181815 no 1777 0.464861400154151 2648 4361398 SGTC_1464 k208-0027 110 µM -0.0883860866704134 0.47445301165529 no 1778 0.464784909622014 2571 X1464 SGTC_1928 4'-methoxychalcone 40.3 µM -0.0898446088395352 0.473877940303577 no 1779 0.464205349389932 2723 641818 SGTC_825 1988-2224 89.6 µM -0.0905518515096099 0.473599105648804 no 1780 0.463924345803626 2567 1180859 SGTC_2778 tioconazole 65.09 nM -0.0912926821523559 0.473307042607377 no 1781 0.463630016252524 2548 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_2954 9074818 52.69 µM -0.0919653172251942 0.473041877224356 no 1782 0.463362797811679 2642 16648742 SGTC_993 3909-8757 62.7 µM -0.0927456290284907 0.472734278626076 no 1783 0.463052823241462 2617 4288324 YLR208W SEC13 SGTC_475 α-linolenic acid 10 µM -0.0930485118040304 0.472614886728397 no 1784 0.462932510758676 2757 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_2666 tannic acid 100 µM -0.0934352764473829 0.472462433420832 no 1785 0.462778883267068 2593 16134267 A thiamine antagonist. SGTC_635 k038-0028 24.7 µM -0.0959102626401225 0.471486949925601 no 1786 0.461795921875253 2600 4035102 SGTC_653 0203-0016 55.2 µM -0.0968396071736705 0.471120704764891 no 1787 0.461426884878165 2652 295302 SGTC_624 k048-0052 28 µM -0.0969298663524961 0.471085135843347 no 1788 0.461391045277825 2628 6835531 SGTC_1604 st002052 72.4 µM -0.0980034693453738 0.470662073087333 no 1789 0.460964769246423 2705 6254834 YHR062C RPP1 SGTC_1046 2001-0062 216 µM -0.0981028970612356 0.470622894384266 no 1790 0.460925293551685 2581 739778 SGTC_2766 oltipraz 83.91 µM -0.0989467192096057 0.470290404442365 no 1791 0.460590287158353 2637 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40 SGTC_1922 5578187 25 µM -0.0989928568017712 0.470272225513048 no 1792 0.460571970846457 2759 1350412 SGTC_459 nigericin 15.3 µM -0.0990127149464826 0.470264401114065 no 1793 0.460564087323129 2680 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification. SGTC_2866 9034245 58.44 µM -0.0998730599651341 0.469925423678248 no 1794 0.460222552212874 2710 6462273 SGTC_556 4058-0063 51.5 µM -0.0999819640786617 0.469882516816741 no 1795 0.460179322134348 2596 6615692 SGTC_2797 7859098 81.82 µM -0.100067538675941 0.469848801738795 no 1796 0.460145353164058 2612 972681 SGTC_205 1486-1330 71.903 µM -0.100155492693571 0.469814149431017 no 1797 0.460110439982266 2572 4118834 SGTC_562 3772-2733 112 µM -0.100503323519117 0.469677112557351 no 1798 0.459972372206294 2603 2876874 YIL048W NEO1 SGTC_3245 9134821 49.47 µM -0.100775454788539 0.469569901968467 no 1799 0.459864355934724 2575 17014901 SGTC_2063 5246145 200 µM -0.10079413215597 0.469562543793228 no 1800 0.45985694249025 2671 711240 SGTC_693 4161-2696 114 µM -0.100943657479306 0.469503636855022 no 1801 0.459797593211752 2693 805759 SGTC_2636 apigenin dimethyl ether 100 µM -0.101297492022855 0.469364242996946 no 1802 0.459657153515413 2688 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_745 0469-0705 296 µM -0.102568503106727 0.468863556613723 no 1803 0.459152720920113 2651 3486736 SGTC_1887 st057648 70.8 µM -0.10339432892635 0.468538267346341 no 1804 0.458825006443282 2733 688672 SGTC_1842 st055362 61.2 µM -0.103968545691118 0.468312098178441 no 1805 0.4585971550809 2594 676032 SGTC_1069 diphenylcyclopropenone 8.49 µM -0.10460470528157 0.468061543274194 no 1806 0.458344740459054 2607 65057 A dermal irritant. YDR527W RBA50 SGTC_3273 9137859 49.47 µM -0.104735837204493 0.468009897824735 no 1807 0.458292712180197 2580 2377234 SGTC_1123 mangostin 811.285 nM -0.104753971887258 0.468002755640997 no 1808 0.458285517067533 2681 5281650 An antioxidant. SGTC_2820 7989630 71.43 µM -0.105107317903254 0.467863595509196 no 1809 0.458145326312149 2585 2984098 SGTC_2598 perillyl alcohol 100 µM -0.105569294906415 0.467681658587086 no 1810 0.457962043846358 2710 10819 An apoptosis inducer. SGTC_47 0149-0135 24.25 µM -0.105578909309826 0.467677872290615 no 1811 0.45795822957043 2553 5239155 SGTC_364 0083-0097 67.7 µM -0.107390731934168 0.466964401907663 no 1812 0.457239503415774 2723 5207356 SGTC_646 4092-0839 27.3 µM -0.108770679402663 0.466421068991676 no 1813 0.45669219012614 2689 877796 SGTC_533 1222-0222 6.71 µM -0.110186200364613 0.46586379458633 no 1814 0.456130853072792 2781 3982874 SGTC_1436 4092-1007 8.32 µM -0.111816699975593 0.465221968561277 no 1815 0.455484372949228 2618 2881121 SGTC_2067 5224629 34.075 µM -0.113040917404914 0.4647401298648 no 1816 0.454999057848473 2722 2835000 SGTC_760 0568-0725 82.9 µM -0.114148329424278 0.464304309026502 no 1817 0.454560105612562 2741 3916171 SGTC_1481 3346-2004 36 µM -0.115975861113078 0.463585179744616 no 1818 0.453835836360735 2623 2770522 SGTC_3183 9108214 49.47 µM -0.117596011825854 0.462947753780719 no 1819 0.4531938825611 2605 4974831 SGTC_2721 ifenprodil 61.44 µM -0.117745318028302 0.46288901607588 no 1820 0.453134728956983 2710 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor. SGTC_2744 captopril 92.04 µM -0.11781740275152 0.462860657924008 no 1821 0.453106170092412 2641 44093 angiotensin-converting enzyme (ACE) inhibitor  SGTC_2734 clemastine 41.6 µM -0.120177556523846 0.461932277813767 no 1822 0.452171248103427 2609 26987 Clemastine is a selective histamine H1 antagonist. SGTC_2876 9059903 25.97 µM -0.121163725569021 0.461544423663208 no 1823 0.451780677595764 2615 6916095 SGTC_1225 1216-0074 20.6 µM -0.121183189109411 0.461536769140661 no 1824 0.451772969563354 2649 4241466 SGTC_2072 5231554 129 µM -0.121662893927073 0.461348117770611 no 1825 0.451583000614567 2704 789545 SGTC_1594 piperine 70.1 µM -0.123545271782207 0.460607927863547 no 1826 0.450837663578125 2634 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_299 1273-0059 1.44 µM -0.124398244369432 0.460272566176261 no 1827 0.45049998167119 2678 2848077 SGTC_2757 clomiphene 4.22 µM -0.125440303499588 0.459862900047714 no 1828 0.450087491252846 2741 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined. SGTC_1713 st033146 12.748 µM -0.125823842986441 0.459712129349586 no 1829 0.449935683895406 2695 674619 SGTC_3317 9138495 8.753 µM -0.126763230289778 0.459342877468932 no 1830 0.449563899442116 2641 17020139 SGTC_3059 1327-0034 3 µM -0.12695423027696 0.459267803978264 no 1831 0.44948831214379 2669 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_1714 st033236 13.627 µM -0.127173307595078 0.459181696342263 no 1832 0.449401615637848 2750 2916566 SGTC_1582 3',3',6'-trihydroxyflavone 74 µM -0.127308953722236 0.459128382027445 no 1833 0.449347936963236 2629 688803 SGTC_19 0279-0214 38.434 µM -0.128113882988532 0.458812028015293 no 1834 0.449029424774759 2631 3566274 YBR002C RER2 SGTC_3188 9110789 49.47 µM -0.128528383049301 0.458649130996309 no 1835 0.448865419035229 2756 849217 SGTC_2758 dehydroepiandrosterone 69.35 µM -0.128791784367913 0.458545618840962 no 1836 0.448761203255916 2697 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem] SGTC_173 1273-0061 2.693 µM -0.129254716199511 0.458363701466253 no 1837 0.448578051006727 2731 2847414 YPL266W DIM1 SGTC_775 4577-0580 57.3 µM -0.129518072975215 0.458260214582155 no 1838 0.448473862615047 2845 2006902 SGTC_1392 3455-1037 33.9 µM -0.131410899410907 0.457516506068749 no 1839 0.447725133475591 2772 981132 SGTC_2993 9054257 71.4286 µM -0.131977543632492 0.457293895273251 no 1840 0.447501026972008 2633 6470217 YGL055W OLE1 SGTC_1254 0550-0035 264 µM -0.132445092978393 0.457110224792269 no 1841 0.447316124882812 2758 15121435 SGTC_2362 9071156 126 µM -0.132510388188923 0.457084575173921 no 1842 0.447290303447353 2788 653133 SGTC_2754 granisetron 64.02 µM -0.134346662671391 0.456363313486144 no 1843 0.446564228092964 2753 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients. SGTC_1136 pergolide 1.05886 µM -0.134421808832655 0.456333800221693 no 1844 0.446534518590615 2662 47811 A dopamine receptor agonist. SGTC_3202 9113761 49.47 µM -0.135155222828621 0.456045768358637 no 1845 0.446244574587416 2841 4798415 SGTC_2335 9018011 154.17 µM -0.138319979417111 0.454803148106733 no 1846 0.444993767995352 2765 6458208 SGTC_323 4013-0906 34.3 µM -0.138939227336545 0.454560055943766 no 1847 0.444749086321286 2770 2910086 SGTC_1452 4194-0072 190 µM -0.139007305695851 0.454533332117726 no 1848 0.444722187994951 2828 1343545 SGTC_519 k048-0011 62.8 µM -0.140910206376272 0.453786441495475 no 1849 0.443970439539653 2786 6836379 SGTC_1772 st048439 82.2 µM -0.141392904533507 0.453597007813745 no 1850 0.443779779660827 2720 2927068 YDL195W SEC31 SGTC_2779 methotrexate 400 µM -0.141629074150075 0.453504327483417 no 1851 0.443686500283655 2645 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2 SGTC_281 1672-3440 14.9 µM -0.142138936048471 0.453304250398609 no 1852 0.443485131932782 2752 6833000 SGTC_3113 9123498 49.47 µM -0.143230992010019 0.452875752000237 no 1853 0.443053877037152 2635 8897275 SGTC_110 0850-0284 111.64 µM -0.143385917765585 0.452814967022448 no 1854 0.442992702024569 2631 3906265 SGTC_854 0422-0053 192 µM -0.14363653013776 0.45271664183016 no 1855 0.442893746436909 2674 3596728 SGTC_1876 myriocin 605 nM -0.144565062958607 0.452352366824847 no 1856 0.442527141559321 2745 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1 SGTC_3130 9127414 49.47 µM -0.145578921152296 0.451954663422814 no 1857 0.442126904584249 2644 1494646 SGTC_2982 9019404 25.97 µM -0.145605485537023 0.451944243730087 no 1858 0.442116418654648 2693 22333232 SGTC_1562 morin hydrate 59.1 µM -0.145687806061644 0.451911954294628 no 1859 0.442083924004717 2839 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase. SGTC_520 3584-0023 682 µM -0.145805705807668 0.451865709805238 no 1860 0.442037385731166 2746 1340790 SGTC_2896 9052656 71.43 µM -0.146182062261586 0.451718093741166 no 1861 0.441888832840047 2676 6469436 SGTC_2731 amoxapine 43.43 µM -0.146780960131797 0.451483205345969 no 1862 0.441652456754675 2654 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine. SGTC_1262 0737-0114 49.6 µM -0.14733877670671 0.451264444355084 no 1863 0.441432313533208 2693 765919 SGTC_2133 5320837 200 µM -0.148044837379407 0.450987567159251 no 1864 0.441153691488762 2797 2841355 SGTC_2973 9094665 17.96 µM -0.148241693901371 0.450910375373312 no 1865 0.441076014162762 2914 25237061 YIL048W NEO1 SGTC_2310 7668677 200 µM -0.149148050095441 0.450554997107094 no 1866 0.440718405692365 2825 2197143 SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM -0.149213644629767 0.450529279314222 no 1867 0.440692526833423 2721 4330530 SGTC_2967 9089538 49.85 µM -0.149877305340523 0.450269088104963 no 1868 0.440430708582202 2870 728216 SGTC_2064 5220758 200 µM -0.150590604894778 0.449989459595072 no 1869 0.440149336539271 2815 788518 SGTC_2898 9056270 58.44 µM -0.151789191417894 0.449519644311656 no 1870 0.439676603675098 2656 19154699 SGTC_1382 3002-2117 298 µM -0.152532477084447 0.449228330829279 no 1871 0.439383488555184 2754 1497314 SGTC_574 1315-0397 40 µM -0.152988270633829 0.449049706702902 no 1872 0.43920376253938 2671 6794277 SGTC_1957 st077035 62.4 µM -0.15300700380642 0.449042365449366 no 1873 0.439196376045244 2689 705593 SGTC_3343 9148379 18.9835 µM -0.1535820221722 0.448817032746434 no 1874 0.438969656486368 2804 1955036 SGTC_1414 3917-0015 5.4 µM -0.155879008549298 0.447917077076314 no 1875 0.438064195892292 2697 6618702 SGTC_1255 0566-0045 221 µM -0.155922146043169 0.447900178423235 no 1876 0.438047194393268 2799 2788469 SGTC_755 1995-0008 37.3 µM -0.157462649686102 0.447296764764997 no 1877 0.437440120936777 2673 689533 SGTC_3248 9135562 49.47 µM -0.157762319641742 0.447179398485783 no 1878 0.437322045662738 2719 17650701 SGTC_103 0844-0104 51.839 µM -0.159222096599567 0.446607740537748 no 1879 0.436746947683683 2817 5375804 SGTC_2216 7189485 200 µM -0.15959968737614 0.446459891597402 no 1880 0.436598212631137 2779 731273 SGTC_2016 5121758 140 µM -0.1606849115558 0.446035004170889 no 1881 0.436170786918027 2657 2795203 SGTC_1651 st011928 86.1 µM -0.160907398217884 0.445947903737115 no 1882 0.436083167650983 2792 720198 SGTC_3006 9075424 71.4286 µM -0.161220484987921 0.445825339039993 no 1883 0.435959873738315 2704 7465181 SGTC_1286 0929-0070 131 µM -0.161769880577974 0.445610278580974 no 1884 0.435743536202391 2808 1420408 SGTC_2302 7771753 200 µM -0.161981700480693 0.445527366122473 no 1885 0.435660132226787 2751 2203047 SGTC_3235 9132602 49.47 µM -0.162163776984324 0.445456097997706 no 1886 0.435588441985934 2786 4912240 SGTC_2746 daunorubicin 9.88 µM -0.162728286830364 0.445235149574641 no 1887 0.435366187085639 2657 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_800 3448-7362 155 µM -0.16372316024495 0.444845798856117 no 1888 0.434974542164535 2747 15991913 SGTC_634 1611-4317 11.2 µM -0.163751469131834 0.444834720750576 no 1889 0.434963398932824 2683 2843522 SGTC_740 k014-0057 261 µM -0.164095987212156 0.444699904081542 no 1890 0.434827790367512 2808 4012779 SGTC_1029 k015-0030 64.7 µM -0.164871573872771 0.444396425272208 no 1891 0.434522533469757 2802 2208316 SGTC_2863 9028737 58.44 µM -0.165881004591481 0.444001494615116 no 1892 0.434125298260033 2817 6460917 SGTC_583 1488-1091 88.9 µM -0.166477510707574 0.443768143092664 no 1893 0.433890590028614 2711 4303273 SGTC_1467 k284-1082 293 µM -0.166754556009527 0.443659770371427 no 1894 0.433781588484298 2806 3334705 SGTC_2571 chrysanthemic acid 100 µM -0.167110008559088 0.443520733001379 no 1895 0.433641745530642 2763 2743 An insecticide. SGTC_2309 7664088 163.95 µM -0.167175681667308 0.443495045336576 no 1896 0.433615909175057 2772 704922 SGTC_831 k061-1017 217 µM -0.168093178247925 0.443136196617457 no 1897 0.433254987981276 2765 1240153 SGTC_2029 5175081 200 µM -0.168614986721578 0.442932129118274 no 1898 0.433049745827682 2700 1380876 SGTC_511 blebbistatin 171 µM -0.169273564985497 0.44267459566105 no 1899 0.432790733999062 2841 3476986 A myosin inhibitor. SGTC_2594 a-mangostin 100 µM -0.170194407772934 0.442314545716424 no 1900 0.432428624755745 2866 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis. SGTC_2384 9036245 200 µM -0.170672114000471 0.44212778111698 no 1901 0.43224079543799 2771 6462766 SGTC_991 3996-0057 64.7 µM -0.171038144904609 0.441984685937646 no 1902 0.432096886101855 2797 715343 SGTC_1364 1653-0028 37.6 µM -0.174683997241089 0.440559802044398 no 1903 0.430663971390039 2784 5718652 SGTC_1657 st012939 43.4 µM -0.176007492431846 0.440042738692162 no 1904 0.430144028115153 2859 24207257 SGTC_879 0831-1030 162 µM -0.177218962338154 0.439569531000979 no 1905 0.429668200806514 2743 1549252 SGTC_2955 9076254 12.21 µM -0.177932217919657 0.43929096926045 no 1906 0.429388104158056 2788 16459619 SGTC_2070 5230947 200 µM -0.179555778190784 0.438657000615428 no 1907 0.428750662110504 2795 2835538 SGTC_3131 9127911 49.47 µM -0.180772616713336 0.438181951960192 no 1908 0.428273028832398 2969 45595681 SGTC_2167 5876490 200 µM -0.181729766430275 0.437808347271895 no 1909 0.427897402348446 2967 686534 SGTC_1348 1493-0373 93.8 µM -0.183770227116786 0.437012078772741 no 1910 0.427096856819452 2802 3010129 SGTC_414 piperonyl butoxide 100 µM -0.183923508913942 0.436952272411865 no 1911 0.427036730981255 2728 5794 A potent inhibitor of cytochrome P450. SGTC_156 3474-0145 5.642 µM -0.18402324409236 0.436913359249365 no 1912 0.426997610082383 2661 2265471 SGTC_3149 9097855 49.47 µM -0.184025574802042 0.436912449895632 no 1913 0.426996695875349 2880 25236625 YMR079W SEC14 SGTC_1350 1495-0454 146 µM -0.184257459791767 0.436821978912888 no 1914 0.426905742325931 2879 1069057 SGTC_2199 6590217 200 µM -0.18481401567469 0.43660484959678 no 1915 0.426687457157658 2785 703109 SGTC_1669 st015249 58.4 µM -0.185032315895393 0.436519689276375 no 1916 0.426601844387953 2802 722793 SGTC_300 r073-0011 5.04 µM -0.187238320440843 0.435659278463799 no 1917 0.425736890364863 2754 2735780 SGTC_2234 tolnaftate 200 µM -0.187594574935854 0.435520356509892 no 1918 0.425597239658798 2772 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7 SGTC_779 1360-0071 233 µM -0.188810411959745 0.435046299128431 no 1919 0.425120705529618 2940 7566 SGTC_2905 7799065 20.05 µM -0.189434528326288 0.434802991075407 no 1920 0.424876132334019 2881 1296806 SGTC_1571 st070080 73.4 µM -0.189740019396067 0.434683906192787 no 1921 0.424756429732913 2879 4315245 SGTC_3330 9141424 71.43 µM -0.18996618771728 0.434595746293286 no 1922 0.424667813162026 2871 27261020 SGTC_1135 dihydrocapsaicin 536.708 nM -0.190052652276689 0.434562043462865 no 1923 0.424633935891999 2720 107982 A Capsaicinoid. SGTC_2576 guaiol 23.12 µM -0.191332677528263 0.434063160995416 no 1924 0.424132480507519 2918 227829 SGTC_1230 0170-0365 3.77 µM -0.191423987391902 0.434027577505115 no 1925 0.424096714159544 2840 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1 SGTC_3016 9080866 49.47 µM -0.191468597723432 0.434010193035487 no 1926 0.424079240385932 2769 17066299 SGTC_51 1013-0126 23.419 µM -0.192298728826482 0.433686717551555 no 1927 0.423754107033671 2963 1627850 SGTC_1040 k898-0338 155 µM -0.193387544488033 0.433262508343562 no 1928 0.4233277346873 2943 20969351 SGTC_945 3381-0768 11.3 µM -0.193681157226608 0.433148128174672 no 1929 0.423212773407511 2855 1126236 YIL048W NEO1 SGTC_389 tpck 16.7 µM -0.193827850010049 0.433090984436074 no 1930 0.423155339689458 2818 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.  SGTC_1814 st052110 31.539 µM -0.193884280516654 0.433069002472167 no 1931 0.423133246237145 2853 674163 SGTC_2655 perillic acid 100 µM -0.195065307365567 0.432608992386808 no 1932 0.422670910774078 2744 5702197 An apoptosis inducer. SGTC_523 1934-0222 13.7 µM -0.195613297600062 0.432395581110455 no 1933 0.422456425689596 2761 1361595 SGTC_1282 0886-0010 32.4 µM -0.195933351384185 0.432270947339272 no 1934 0.422331166272635 2887 2836211 YNL267W PIK1 SGTC_1587 estradiol valerate 56.1 µM -0.196012562180306 0.432240102500372 no 1935 0.422300166763474 2879 13791 A steroid. SGTC_2414 st077232 92.9 µM -0.196216430262295 0.43216071777037 no 1936 0.422220384266433 2725 729801 SGTC_2246 7293507 91.5585 µM -0.197324457669133 0.431729308033098 no 1937 0.421786820571932 2933 887656 SGTC_2203 7227154 166.4 µM -0.197755705228401 0.431561424061764 no 1938 0.421618101889638 2759 896304 SGTC_177 1327-0068 8.361 µM -0.197886477660805 0.431510517008397 no 1939 0.421566942117164 2736 15389900 YOR207C | YLR033W RET1 | RSC58 SGTC_1628 st004252 77.7 µM -0.198809010405696 0.431151426102419 no 1940 0.421206073702326 2909 692968 SGTC_1739 st037196 92.5 µM -0.19916240322684 0.431013884906223 no 1941 0.421067854057086 2892 612214 SGTC_2817 7995342 71.43 µM -0.199463444465263 0.430896725649439 no 1942 0.420950117930802 2740 18879975 SGTC_74 000s-0487 160.283 µM -0.20269931943042 0.429637773590072 no 1943 0.419685027575415 2730 677548 SGTC_2584 androsterone 48.74 µM -0.204857052712287 0.428798680831147 no 1944 0.418841905254474 2895 2754130 A steroid. SGTC_1154 4088-0362 150 µM -0.206783323025161 0.428049870355092 no 1945 0.418089540482282 2751 6618304 SGTC_263 alizarin 107.927 µM -0.207546072976469 0.427753433485718 no 1946 0.417791707431481 2748 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. SGTC_1612 st002233 45.4 µM -0.207785818171724 0.427660266784461 no 1947 0.4176981032024 2762 1035021 SGTC_2427 5545055 42.75 µM -0.20911130744821 0.42714524508512 no 1948 0.41718067388523 2798 5372858 SGTC_1956 st077085 54 µM -0.211077446073416 0.426381526620315 no 1949 0.416413419584569 2822 24208685 SGTC_2088 5278280 127.392 µM -0.211251523716714 0.426313921903348 no 1950 0.416345503854614 2863 791502 SGTC_1476 4112-3294 3.34 µM -0.212244698745719 0.425928254359993 no 1951 0.415958068228982 2901 704369 SGTC_1766 st045414 44.774 µM -0.212925598454174 0.425663889791135 no 1952 0.415692497753466 2770 253960 SGTC_2304 7443016 91.4 µM -0.21293472595381 0.425660346195614 no 1953 0.415688938027257 2729 939854 SGTC_679 0422-0091 41.4 µM -0.213013044725179 0.425629940519842 no 1954 0.415658393979229 2766 627384 YHR062C RPP1 SGTC_71 0417-1750 47.813 µM -0.213114160545984 0.425590685005718 no 1955 0.415618959914985 2998 6811472 SGTC_1351 1496-0003 46.5 µM -0.213150362672248 0.42557663067733 no 1956 0.415604841688234 2909 3891978 SGTC_3234 9132280 49.47 µM -0.213765746870484 0.425337741741107 no 1957 0.415364868772349 2859 17612295 SGTC_2781 5567276 71.43 µM -0.21559619873108 0.424627332218213 no 1958 0.414651259548274 2950 2853274 SGTC_1732 st034308 51.822 µM -0.216918336182098 0.424114354720411 no 1959 0.414135993801084 2724 830119 SGTC_1047 2043-3044 82 µM -0.217265500685724 0.423979679272126 no 1960 0.414000720693647 2795 669592 SGTC_1403 3909-7815 62.9 µM -0.219506184572403 0.423110665499707 no 1961 0.413127881373354 2763 6615483 SGTC_2728 chlorpromazine 9.18 µM -0.219764922432671 0.423010342121231 no 1962 0.413027119806411 2759 2726 A thorazine and dopamine antagonist. SGTC_1430 4049-0248 69.1 µM -0.221427890884056 0.422365659849669 no 1963 0.412379638787988 2903 22774488 SGTC_1093 fluphenazine 7.97 µM -0.221669258543487 0.422272106190649 no 1964 0.412285681442505 2809 6602611 An atypical antipsychotic. SGTC_874 0599-0792 117 µM -0.221703845567998 0.422258700682914 no 1965 0.412272218140679 2959 765305 SGTC_1697 st025554 27.742 µM -0.22211639475939 0.422098808609231 no 1966 0.412111637723314 2779 1269519 SGTC_2293 7624732 200 µM -0.222365305535197 0.422002344236673 no 1967 0.412014758946948 2758 894453 SGTC_1479 0549-0158 134 µM -0.22324601323643 0.421661067107139 no 1968 0.411672021036579 2841 5440202 SGTC_1575 cyproterone acetate 48 µM -0.223475223927639 0.421572256848569 no 1969 0.411582832001111 2850 9880 An androgen receptor antagonist and liver toxin. SGTC_3354 9151612 71.43 µM -0.223475951977449 0.421571974763841 no 1970 0.411582548714184 2945 27261949 SGTC_2019 4016004 108 µM -0.223614091416625 0.421518453019406 no 1971 0.411528798971404 2869 45595336 SGTC_336 4111-0029 111 µM -0.223854580766012 0.421425279544592 no 1972 0.41143522907228 2853 3131175 SGTC_699 0375-0592 111 µM -0.225816032888264 0.420665513275258 no 1973 0.410672253348782 2879 762578 SGTC_2000 st075254 36.4 µM -0.22806535475798 0.419794604776893 no 1974 0.409797716626304 2817 17234175 SGTC_247 mechlorethamine 29.705 µM -0.228333741169899 0.419690715148072 no 1975 0.40969339781278 2791 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links. SGTC_3240 9133527 49.47 µM -0.228884450025558 0.419477558928101 no 1976 0.40947936342934 2843 17617455 SGTC_200 k038-0079 37.545 µM -0.231380214896922 0.418511850440914 no 1977 0.408509717194469 2845 3436683 SGTC_691 1548-0686 185 µM -0.235452144408167 0.416937318924081 no 1978 0.406928909009691 2841 46495133 SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM -0.236958078877027 0.416355340894018 no 1979 0.406344656163912 2915 6708739 YPR165W RHO1 SGTC_1215 3852-0577 11.2 µM -0.237097972502023 0.416301287392367 no 1980 0.406290392619063 2981 2884876 SGTC_1728 st035614 33.7865 µM -0.238936777006792 0.415590939187409 no 1981 0.40557730370819 2935 15945546 SGTC_1758 st042942 75.2445 µM -0.239406242242941 0.415409624260931 no 1982 0.405395295059882 2820 669317 SGTC_260 nsc-65238 3.989 µM -0.240561213252536 0.414963632860339 no 1983 0.404947607381715 2945 3246252 SGTC_3299 9121982 43.1275 µM -0.24129605351529 0.414679931706237 no 1984 0.404662834690197 2865 17594604 YPL160W CDC60 SGTC_621 3584-0052 32.1 µM -0.24186850613754 0.414458954678091 no 1985 0.404441027069868 2900 2273927 SGTC_2550 chrysin dimethyl ether 71.87 µM -0.242713977398327 0.414132637071371 no 1986 0.404113489392843 2791 88881 An O-methylated flavonoid and antioxidant. SGTC_3071 9117417 49.47 µM -0.245225555057604 0.413163620374329 no 1987 0.403140895148281 2909 45595590 YGL055W OLE1 SGTC_3080 9117754 49.47 µM -0.24522594818148 0.413163468740543 no 1988 0.403140742960006 3049 9550191 SGTC_673 1082-0474 110 µM -0.246065101129048 0.412839824400985 no 1989 0.402815918938093 2861 3098046 SGTC_1771 st048882 4.1505 µM -0.246301095784282 0.412748816692774 no 1990 0.40272458087856 2823 4580403 SGTC_3261 9137475 49.47 µM -0.247512132133709 0.412281873039597 no 1991 0.402255951728637 2821 17027690 SGTC_1330 1469-0054 61.8 µM -0.249063956259731 0.411683712151458 no 1992 0.401655654886568 2999 7102664 SGTC_2252 omeprazole 400 µM -0.249561329133044 0.411492039836951 no 1993 0.401463303650919 2903 4594 A proton pump inhibitor. SGTC_2164 5685496 200 µM -0.24959788976882 0.411477951317358 no 1994 0.401449165334159 2882 759046 SGTC_2263 7948595 193.29 µM -0.25237492994991 0.410408162987303 no 1995 0.40037563804988 2847 2971371 SGTC_3090 9117696 49.47 µM -0.252776339273831 0.410253584571021 no 1996 0.400220526288306 2922 7923821 SGTC_2860 9025725 38.96 µM -0.253933092693877 0.409808209325447 no 1997 0.399773624126642 2819 40546248 SGTC_191 3914-0123 66.505 µM -0.254133300208871 0.40973113686919 no 1998 0.399696288909957 2844 3144412 SGTC_489 paxilline 115 µM -0.254435357650054 0.409614862576455 no 1999 0.399579619030323 2919 105008 A toxic potassium channel blocker. SGTC_1652 st011932 78 µM -0.254836201851999 0.409460573485094 no 2000 0.399424806547181 2956 1551076 SGTC_3167 9103034 49.47 µM -0.255333896639159 0.409269025114615 no 2001 0.399232610817552 2833 5127859 SGTC_2831 7999036 19.48 µM -0.256244878106753 0.408918470760502 no 2002 0.398880878690478 3137 2988270 SGTC_2402 5553605 200 µM -0.256906396136883 0.408663957952105 no 2003 0.398625516431467 3048 6758546 SGTC_1689 st020265 53.493 µM -0.257030879882786 0.408616068310138 no 2004 0.398577467486504 2990 5758320 YPR016C TIF6 SGTC_447 ml7 120 µM -0.257125447531261 0.408579688481854 no 2005 0.398540966754671 2915 4216 Selective myosin light chain kinase inhibitor. SGTC_564 3555-0129 330 µM -0.258148722263936 0.408186088879839 no 2006 0.398146065289669 2874 563260 SGTC_217 ketoconazole 989 nM -0.259927200338932 0.40750222314033 no 2007 0.397459964682498 2943 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4 SGTC_1209 2323-2347 50.3 µM -0.260462851407268 0.407296308103022 no 2008 0.397253383455306 2889 5412760 SGTC_1094 duloxetine 25.4 µM -0.260633718542644 0.407230628727952 no 2009 0.397187492246562 2853 60834 A selective serotonin reuptake inhibitor. SGTC_2980 9014342 25.29 µM -0.262624106392969 0.406465738993815 no 2010 0.396420158938641 3053 2996599 SGTC_2325 6158266 200 µM -0.263497335329862 0.406130276691751 no 2011 0.396083638552941 2952 3623240 SGTC_2240 6690706 185.951 µM -0.264882643601976 0.405598233873434 no 2012 0.395549934653285 2795 805876 SGTC_2893 9048488 25.97 µM -0.265340589828641 0.405422392905542 no 2013 0.395373549294118 2908 6467338 SGTC_856 0433-0016 11.3 µM -0.265680937892554 0.405291719327877 no 2014 0.395242472640944 2946 3911780 SGTC_3265 9137266 49.47 µM -0.266276075791442 0.405063246862269 no 2015 0.395013298464205 2957 17224265 SGTC_3168 9103419 49.47 µM -0.269002338777374 0.404017053666318 no 2016 0.393963941450737 2929 16649256 SGTC_138 0850-0259 40.9225 µM -0.269252379039066 0.40392113589354 no 2017 0.393867737670897 2963 6813004 SGTC_3295 9122362 53.5725 µM -0.270196394715873 0.403559054811962 no 2018 0.393504583091303 2991 4730473 SGTC_886 0866-0150 153 µM -0.272433029725556 0.402701514680574 no 2019 0.392644539371686 3068 271463 SGTC_2453 5731132 22.18 µM -0.27407951520252 0.402070540395511 no 2020 0.392011757892314 3044 1362040 SGTC_2934 9036370 36.88 µM -0.274862821619184 0.401770447304378 no 2021 0.391710815701807 2990 6462800 SGTC_2006 4011487 200 µM -0.276158763191615 0.401274085426096 no 2022 0.391213064132044 3047 45595294 SGTC_985 1493-0307 8.71 µM -0.276508090012031 0.401140316093448 no 2023 0.391078923423475 3038 3278274 SGTC_846 0335-0850 148 µM -0.276726478322542 0.401056693534901 no 2024 0.390995069387269 2972 6819598 SGTC_2569 tetrandrine 100 µM -0.27690339093474 0.400988955662247 no 2025 0.390927144390629 2943 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_207 4185-0010 4.486 µM -0.278701821226461 0.400300525954901 no 2026 0.390236832368251 2976 3761753 SGTC_2965 9082772 38.63 µM -0.2798088297391 0.399876922711615 no 2027 0.389812088521447 3083 16459634 SGTC_382 3229-0966 23.2 µM -0.280565878453827 0.399587301413111 no 2028 0.389521695116689 3075 5722370 SGTC_3061 glucosamine 200 µM -0.281841630551466 0.399099366760759 no 2029 0.389032473890359 2990 91431 and experimental redox chemotherapeutic SGTC_377 3970-0964 33.1 µM -0.28285784236892 0.398710810755605 no 2030 0.388642906125797 2894 16481235 SGTC_1869 3',7'-dimethoxyflavone 40.3 µM -0.283392941607725 0.39850625197224 no 2031 0.38843781924773 2931 688664 SGTC_863 0466-0191 129 µM -0.28345140443796 0.398483904375788 no 2032 0.388415414148564 3028 765160 YPR165W RHO1 SGTC_865 0488-0499 301 µM -0.285306074746846 0.397775124121037 no 2033 0.387704829606863 3057 9634651 SGTC_2236 dapsone 200 µM -0.286746238053584 0.397224984247088 no 2034 0.387153315344184 2935 2955 A bacterial DFR inhibitor. An anti-cancer agent. SGTC_2567 aureobasidin a 60 nM -0.28680679787794 0.397201854970719 no 2035 0.387130128784431 3158 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1 SGTC_656 4090-1979 187 µM -0.287324384087646 0.39700419090916 no 2036 0.386931976820711 3048 22330961 SGTC_2349 9023730 187.07 µM -0.28740381384048 0.396973859350909 no 2037 0.386901570654529 3063 4126287 SGTC_735 3076-0345 636 µM -0.287546570217511 0.396919347045776 no 2038 0.386846924437346 3070 2888990 SGTC_2202 7226349 200 µM -0.287601698365717 0.396898296599195 no 2039 0.386825822339326 2901 844334 SGTC_3144 9087057 49.47 µM -0.288647634921127 0.396498967204482 no 2040 0.386425519442931 3020 17249618 SGTC_176 1486-1328 72.834 µM -0.28900644214189 0.396362002740965 no 2041 0.386288223853656 2982 22310231 SGTC_1761 st044296 37 µM -0.289159191214371 0.396303699002085 no 2042 0.386229779589282 2894 1826700 SGTC_1394 3474-0001 65.7 µM -0.289399794190923 0.39621186646663 no 2043 0.386137726236825 2953 5017666 YIL048W NEO1 SGTC_3257 9139206 32.98 µM -0.290025822897086 0.395972952930978 no 2044 0.385898241203717 3035 4910041 SGTC_900 1112-0045 141 µM -0.292020666304773 0.395211914857281 no 2045 0.385135411445766 2955 56211 YIL048W NEO1 SGTC_1205 4161-2785 76 µM -0.292320061996444 0.395097729013628 no 2046 0.385020960560132 3022 3498106 SGTC_913 3487-1245 167 µM -0.29277827214046 0.394922990732119 no 2047 0.384845818597548 2867 4016153 SGTC_1613 st002381 52.1 µM -0.293873744243499 0.394505318539151 no 2048 0.384427190872248 2931 551167 SGTC_131 0141-0277 33.849 µM -0.295290446715283 0.393965350244139 no 2049 0.383886006872172 3106 1547771 SGTC_1442 4112-3290 3 µM -0.296061533127794 0.393671540502947 no 2050 0.383591544936382 2932 704353 SGTC_421 streptovitacin 30 mM -0.296556992087703 0.393482785978025 no 2051 0.383402374877558 3109 91467 include heat shock SGTC_1891 st059073 26.2 µM -0.297120042934883 0.393268311423614 no 2052 0.383187431455393 3119 688754 SGTC_684 1140-0066 328 µM -0.299377295974652 0.392408815515381 no 2053 0.382326091708042 2992 6813534 SGTC_1646 st011709 75.6 µM -0.300139583347383 0.392118677060632 no 2054 0.382035343537888 3052 5757843 SGTC_2249 haloperidol 116.36 µM -0.300928669455474 0.391818401759608 no 2055 0.381734443980327 2904 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_2452 5863136 48.41 µM -0.30206014716124 0.39138794676169 no 2056 0.3813031060945 2894 2184096 SGTC_570 0987-0065 62.6 µM -0.303606567752173 0.390799847657348 no 2057 0.380713823651573 2880 3104428 SGTC_2969 9091408 28.7 µM -0.304412079785052 0.390493612661809 no 2058 0.380406982942894 2919 4286311 SGTC_2886 9058944 51.95 µM -0.30456582586664 0.390435170061911 no 2059 0.380348425563056 2978 4949929 SGTC_1335 1486-0900 202 µM -0.30564596998823 0.390024651046614 no 2060 0.379937107671064 2907 X1335 SGTC_269 exalamide 29 µM -0.306437449186803 0.389723919692049 no 2061 0.37963579928548 2954 3316 A derivative of salicylamide. SGTC_918 glabranin 770.725 nM -0.307278957142596 0.389404251755534 no 2062 0.379315525589706 2990 124049 Also referred to as licorice root. SGTC_1914 st062367 72.6 µM -0.309988796623874 0.388375360594632 no 2063 0.378284738004243 2943 978205 SGTC_1946 st076057 65.1 µM -0.310430865383095 0.388207586856232 no 2064 0.378116662749562 2923 953009 SGTC_987 1497-1013 404 µM -0.310471815349484 0.388192046598429 no 2065 0.378101094673069 2946 1676435 SGTC_1068 loratadine 26.9 µM -0.312382828025672 0.387467028667482 no 2066 0.377374799564014 3005 3957 A H1 histamine antagonist. SGTC_3103 9120822 49.47 µM -0.313899300800257 0.386891974006355 no 2067 0.3767987607226 3179 17141819 SGTC_1999 st074831 12.5 µM -0.314649398468506 0.386607624592126 no 2068 0.376513934091104 2980 17112523 SGTC_3306 9127676 59.7925 µM -0.315215123798604 0.386393207888115 no 2069 0.376299161668473 3041 41905287 SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM -0.315444121072419 0.386306425025155 no 2070 0.376212235842656 2989 6708561 SGTC_2610 ononetin 44.17 µM -0.317518630680986 0.385520509864217 no 2071 0.375425052530666 3019 259632 SGTC_2713 st079149 53.4 µM -0.317587635843283 0.385494375740527 no 2072 0.375398877058692 3038 3103253 SGTC_443 clozapine 122 µM -0.318514657355082 0.385143338039794 no 2073 0.375047289092349 3022 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_833 3852-0053 558 µM -0.31867457675898 0.385082790442836 no 2074 0.374986647550729 3130 3123681 SGTC_1109 tnp00067 928.257 nM -0.318862592033952 0.385011608961614 no 2075 0.374915355989138 2986 676295 SGTC_960 1222-0186 7.7 µM -0.319271330263743 0.384856876434666 no 2076 0.374760385528245 3084 3126296 SGTC_2664 lyso-paf C-16 73.48 µM -0.320819730760994 0.384270878230352 no 2077 0.37417350307711 2968 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_531 3788-1495 174 µM -0.321259460271156 0.384104509033141 no 2078 0.374006887698032 2915 2896655 SGTC_1667 st014849 34.6 µM -0.321508278649105 0.384010379451053 no 2079 0.373912619782526 2953 5348460 SGTC_3099 9120367 49.47 µM -0.321883783121994 0.383868336665497 no 2080 0.373770369554452 2955 24824940 SGTC_561 1550-0330 72.9 µM -0.324718702605893 0.382796471064238 no 2081 0.372696989223911 2976 6812934 SGTC_1556 plumbagin 1.48 µM -0.32630518444321 0.382197022956416 no 2082 0.372096733048549 3002 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_1261 0712-0010 12.7 µM -0.328950755276593 0.38119802917663 no 2083 0.371096454988693 3171 2840123 SGTC_1354 1498-1681 81 µM -0.330546964210488 0.380595667087358 no 2084 0.37049335626915 3084 5754243 SGTC_2882 9058044 58.44 µM -0.330565572152712 0.380588646703271 no 2085 0.370486327467462 3068 18076804 SGTC_1176 0848-0131 83.3 µM -0.330726082852684 0.380528091034746 no 2086 0.370425699351754 3068 6769040 SGTC_1041 0206-0046 107 µM -0.331103216712794 0.380385821742493 no 2087 0.370283260983905 3049 50494 SGTC_1645 Cervolide 78 µM -0.332355933465493 0.379913365372183 no 2088 0.369810254532779 3038 23173 A fragrance. SGTC_290 2043-6722 48.1 µM -0.332878133277275 0.379716472982404 no 2089 0.369613138075638 3081 773758 YLR208W SEC13 SGTC_2531 methyl deoxycholate 70.07 µM -0.333038171425785 0.379656137773023 no 2090 0.369552734813328 2966 16667744 Haematoxylin. SGTC_2696 st077691 74.316 µM -0.334225592771351 0.379208565396057 no 2091 0.369104666548967 3153 757133 SGTC_2211 7117706 200 µM -0.334762961606047 0.379006069189915 no 2092 0.368901951164737 3092 822771 SGTC_2028 5153890 36.43 µM -0.336821011946511 0.378230843483772 no 2093 0.368125916214618 2996 2830968 YPR165W RHO1 SGTC_1147 3809-1045 12.3 µM -0.337442294775308 0.377996915011575 no 2094 0.367891752853588 3017 325925 SGTC_2221 6807166 181.081 µM -0.339617807634663 0.377178133216178 no 2095 0.367072182939589 3060 674925 SGTC_3175 9106517 49.47 µM -0.340221212153562 0.37695113189645 no 2096 0.366844972500489 3079 41468073 SGTC_2345 9052315 157.45 µM -0.340541284120839 0.376830737792512 no 2097 0.366724469140746 3091 6469265 SGTC_710 3448-4187 58 µM -0.34117105681238 0.376593885671101 no 2098 0.366487405428057 3043 3946412 SGTC_36 0335-0881 14.2 µM -0.341939520800966 0.376304935865217 no 2099 0.366198203504973 3017 23828853 SGTC_1164 k060-0068 93.7 µM -0.342368640734958 0.376143612815876 no 2100 0.366036742574181 3013 5963676 SGTC_815 1582-0027 36.9 µM -0.343059655003343 0.375883878881541 no 2101 0.36577679098243 3100 3128206 SGTC_1058 3448-5425 97.3 µM -0.34385602982609 0.375584612447953 no 2102 0.365477280398202 3010 7279705 SGTC_2187 6125751 200 µM -0.345617614800694 0.374922899746799 no 2103 0.364815053097815 3044 874498 SGTC_2370 9071495 200 µM -0.345801456726055 0.374853863488439 no 2104 0.364745965156074 3086 21791103 SGTC_858 0438-0351 2.77 µM -0.347281756434494 0.37429812815139 no 2105 0.364189827583757 3049 2799119 SGTC_1676 st018489 23.4 µM -0.347484244323795 0.374222130254486 no 2106 0.364113776591226 3015 3696235 SGTC_1777 st045864 34.765 µM -0.347581748817823 0.374185536542478 no 2107 0.364077157477241 3091 4691462 SGTC_211 3455-0679 143.504 µM -0.348901590072791 0.373690308042178 no 2108 0.363581595701369 3103 748649 SGTC_2113 5491891 107.031 µM -0.349641504162107 0.373412769929703 no 2109 0.363303879363914 3038 789979 SGTC_847 0342-0274 5.54 µM -0.35039776371662 0.373129168556511 no 2110 0.363020102222397 3144 18097 SGTC_1573 oleylamine 1.06 µM -0.350759977056407 0.372993360950927 no 2111 0.362884212721173 3007 5356789 An amine of the fatty acid oleic acid. SGTC_2288 7946289 167.31 µM -0.351310646310116 0.372786924268545 no 2112 0.362677654374263 3220 1246052 SGTC_871 0574-0004 149 µM -0.351529951128831 0.372704720731874 no 2113 0.362595403338683 3004 9551173 SGTC_2859 9028643 45.46 µM -0.352634642118363 0.372290730014097 no 2114 0.362181181622083 3085 17151580 SGTC_2651 TUB2.036 5 µM -0.353039869990761 0.372138904982257 no 2115 0.362029275311517 3189 15992207 YFL037W TUB2 SGTC_2619 obliquin 87.91 µM -0.353272765536239 0.372051655974742 no 2116 0.361941980430642 2992 6708593 A bioactive alkalod. YER133W GLC7 SGTC_2852 9023854 51.95 µM -0.35456271014779 0.371568526694399 no 2117 0.361458608169779 3188 19798528 SGTC_3268 9137683 49.47 µM -0.356114974207841 0.37098741777912 no 2118 0.360877231790054 3016 1953228 SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM -0.356418025313718 0.370874001185366 no 2119 0.360763766155527 3173 756377 SGTC_613 3914-0030 117 µM -0.356789930146071 0.37073483147936 no 2120 0.360624537684833 2944 1145395 SGTC_2456 5770359 74.46 µM -0.35689271107913 0.370696373029622 no 2121 0.360586063270327 3192 3118787 SGTC_1072 oxiconazole 14.9 nM -0.357328925282069 0.370533165288707 no 2122 0.360422789101442 3079 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_2561 acetosyringone 100 µM -0.359612358455647 0.369679209007359 no 2123 0.359568520176852 2998 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent. SGTC_2069 5228469 200 µM -0.359747790250846 0.369628580485197 no 2124 0.359517874962311 3138 2835210 SGTC_2364 9055074 200 µM -0.360147033293271 0.369479344454421 no 2125 0.359368590929513 3114 6470630 SGTC_3139 9095020 49.47 µM -0.362278718674945 0.368682859170047 no 2126 0.358571879823667 2930 25236292 SGTC_1267 0828-0272 9.49 µM -0.362331161788488 0.368663271358754 no 2127 0.35855228710379 3183 745334 SGTC_288 1315-0019 35.1 µM -0.36313854740941 0.368361751175056 no 2128 0.358250695271354 3136 6811474 SGTC_3050 9093513 49.47 µM -0.364821780883395 0.367733404230162 no 2129 0.357622222631964 3056 25236664 SGTC_1907 st060210 83.7 µM -0.365403356156515 0.367516385764123 no 2130 0.35740516817609 3194 688793 SGTC_652 0437-0092 114 µM -0.365951287093631 0.367311960593348 no 2131 0.357200712592645 3066 3091274 SGTC_2751 anetholtrithion 17.25 µM -0.366799232975704 0.366995678291245 no 2132 0.356884389909829 3173 2194 A chloretic substance that stimulates the liver to produce bile. SGTC_458 nppb 133 µM -0.367398539681118 0.366772192380917 no 2133 0.356660880357287 3238 4549 A chloride channel blocker. SGTC_2275 7947463 200 µM -0.3683132100097 0.36643119210487 no 2134 0.356319851817543 3187 1225414 SGTC_807 1315-0151 48 µM -0.36873250999013 0.366274907173348 no 2135 0.356163557087676 3260 4011080 SGTC_92 0063-0024 660.874 µM -0.370583555930362 0.365585235513848 no 2136 0.355473865899335 3090 3594437 SGTC_2515 chrysin 20.77 µM -0.371194934381604 0.365357540471507 no 2137 0.355246172905989 3146 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor. SGTC_2183 6420625 130.508 µM -0.371230309820626 0.36534436708485 no 2138 0.355232999767046 3111 2897619 SGTC_1404 3909-7820 48.3 µM -0.372494854970482 0.36487357017646 no 2139 0.354762220992552 3161 23741373 SGTC_669 0108-0021 26.2 µM -0.373572306328242 0.364472589943119 no 2140 0.354361270453231 3369 17201 SGTC_221 trifluoperazine 10.304 µM -0.375521377624248 0.363747607845187 no 2141 0.353636375362497 3095 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1 SGTC_3218 9131285 49.47 µM -0.37578775366078 0.363648563670058 no 2142 0.353537346408739 3244 17156417 SGTC_2026 5148700 152 µM -0.376345344074761 0.36344126941141 no 2143 0.353330086604588 3046 79838 SGTC_2881 9058953 51.95 µM -0.376547700875723 0.363366049517883 no 2144 0.353254880082744 3028 17122249 SGTC_600 1495-0418 41.6 µM -0.376553667124602 0.363363831828995 no 2145 0.353252662795117 3066 5377768 SGTC_467 ro 31-8220 72.8 µM -0.377382980982724 0.36305561570829 no 2146 0.352944506358389 3088 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7 SGTC_3250 9135583 49.47 µM -0.378760986569286 0.362543673391849 no 2147 0.352432680374424 3208 7699353 SGTC_1802 st050112 57.9 µM -0.379385847948411 0.362311612284789 no 2148 0.352200679078677 3091 4662563 SGTC_1910 st062352 60.4 µM -0.38032727189671 0.36196208167318 no 2149 0.351851246896719 2994 2245730 SGTC_2115 tiliquinol 12.7705 µM -0.381467011529439 0.361539074722903 no 2150 0.351428372488702 3131 71208 A bioactive hydroxyquinoline. SGTC_1410 3909-8106 77.9 µM -0.381707236858528 0.361449938223957 no 2151 0.351339265795466 3169 1039210 SGTC_1167 k781-0610 148 µM -0.382083276017953 0.361310422599473 no 2152 0.351199798134453 3108 4525169 SGTC_1533 dihydroergotamine mesylate 29.4 µM -0.382919546660517 0.361000220993969 no 2153 0.350889708911236 3125 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release. SGTC_893 0958-0369 48.9 µM -0.385776154340005 0.359941297189939 no 2154 0.349831228466733 3198 6819948 SGTC_1030 k029-0042 36.7 µM -0.386976838557115 0.359496532339791 no 2155 0.349386677427893 3121 6080581 SGTC_1466 k213-0079 57.5 µM -0.387295628408103 0.359378476178756 no 2156 0.349268680765068 3092 3657981 SGTC_366 0181-0206 4.31 µM -0.387648468435935 0.359247826002686 no 2157 0.349138097777657 3286 274874 SGTC_943 3253-1379 105 µM -0.388380306992657 0.358976892119462 no 2158 0.348867307725861 3260 668464 SGTC_588 3970-1144 52.9 µM -0.389481422695992 0.358569381845869 no 2159 0.348460025230846 3181 1888707 SGTC_2959 9079155 11 µM -0.390831522441506 0.358069945165605 no 2160 0.347960886477392 3237 16189457 SGTC_1192 1488-0095 21.4 µM -0.390933639349269 0.358032179356475 no 2161 0.347923144037726 3164 915875 SGTC_2393 9031399 185.94 µM -0.391002146103833 0.358006844340297 no 2162 0.34789782476516 3225 1526623 YDL150W RPC53 SGTC_2676 harmalol 100 µM -0.391392691983254 0.357862425475566 no 2163 0.347753496661933 3179 5459187 A monoamine oxidase inhibitor SGTC_1932 st074806 40.9 µM -0.391712244553002 0.357744274158059 no 2164 0.347635420885288 3330 17251235 SGTC_2634 4'-methoxyflavone 100 µM -0.391780531907116 0.357719027369411 no 2165 0.34761019038863 3149 77793 From seeds of Psoralea corylifolia (Fabaceae) SGTC_1272 0839-0021 27 µM -0.392513935965151 0.357447916908636 no 2166 0.347339258214365 3167 5027250 SGTC_1162 k048-0130 20.1 µM -0.392807627073796 0.357339371087698 no 2167 0.347230785486724 3085 6797406 SGTC_2191 5911152 200 µM -0.392877994739901 0.357313365490094 no 2168 0.347204797546342 3142 2875902 SGTC_2048 5246248 200 µM -0.392956347184585 0.357284409758137 no 2169 0.347175861540823 3224 677046 SGTC_1840 st055363 71 µM -0.393804541432543 0.356971005860355 no 2170 0.346862675613865 3129 676033 SGTC_2175 5807670 165.306 µM -0.394508805170152 0.356710856941555 no 2171 0.34660271383364 3214 241186 SGTC_3247 9135149 49.47 µM -0.394677589003014 0.356648519551179 no 2172 0.346540422122409 3113 8934436 YOR116C RPO31 SGTC_777 1315-0167 517 µM -0.396115888189739 0.356117464095891 no 2173 0.346009768934473 3162 4221767 SGTC_127 0180-0333 59.125 µM -0.396612632366104 0.355934118683607 no 2174 0.345826567862682 3164 771601 SGTC_1602 st001878 87.6 µM -0.396708855573676 0.355898607102584 no 2175 0.345791084562617 3250 595405 YLR310C CDC25 SGTC_832 4083-0019 164 µM -0.397238871676729 0.355703024839374 no 2176 0.34559565994412 3225 1990758 SGTC_2207 7258803 200 µM -0.39734420179733 0.355664161291015 no 2177 0.345556828101052 3181 3666799 SGTC_2378 9074213 121.43 µM -0.39991674338958 0.354715439900493 no 2178 0.344608919823792 3106 657714 SGTC_2058 5236698 133 µM -0.400882922923454 0.354359357155302 no 2179 0.344253161693465 3123 766665 SGTC_903 1134-0042 114 µM -0.405481613300322 0.352666272063754 no 2180 0.342561765529348 3126 701009 SGTC_1516 st013856 110 µM -0.405550153970085 0.352641059624856 no 2181 0.342536580060657 3203 5281404 A mutagen and neurotoxin. SGTC_2681 menadione 3.18 µM -0.406019189873335 0.352468543830099 no 2182 0.342364250244335 3217 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_465 cgp-37157 41 µM -0.406988126736122 0.352112255907139 no 2183 0.342008354343495 3170 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange. SGTC_1718 roemerine 11.9335 µM -0.407696671731825 0.351851798847715 no 2184 0.341748190630102 3211 235224 An aporphine alkaloid with mutagenic activity. SGTC_106 0092-0003 11.579 µM -0.410640128255323 0.350770546524073 no 2185 0.340668217290266 3168 1072148 SGTC_1506 4226-2149 212 µM -0.41085503904005 0.350691648175562 no 2186 0.34058941613451 3212 991114 SGTC_3077 9117319 49.47 µM -0.412192004711579 0.350200964214986 no 2187 0.340099348455777 3167 17154678 SGTC_2924 9010168 62.78 µM -0.414950752088465 0.34918925847213 no 2188 0.339088977759876 3220 2993929 SGTC_857 0438-0306 1.35 µM -0.416431534748409 0.348646657391238 no 2189 0.338547128481208 3229 4686136 SGTC_167 3672-0051 66.205 µM -0.416808357879981 0.348508627981074 no 2190 0.338409294310312 3090 3237971 SGTC_2025 5147754 141 µM -0.417716302231922 0.348176132549207 no 2191 0.338077275839382 3166 315777 YLR208W SEC13 SGTC_677 0929-0063 136 µM -0.418142003799543 0.348020277881081 no 2192 0.337921647982057 3197 1539583 SGTC_1035 k081-0041 55.2 µM -0.418207730959404 0.347996216632798 no 2193 0.337897621933724 3287 731709 SGTC_451 chloral hydrate 100 µM -0.418325990290783 0.347952926068609 no 2194 0.337854394824814 3224 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1 SGTC_1964 st076914 61 µM -0.418414216383494 0.347920630902976 no 2195 0.337822147101371 3177 24208661 SGTC_481 bay k-8644 50 µM -0.418613918869609 0.347847533872978 no 2196 0.337749157780383 3154 2303 A calcium channel antagonist. SGTC_924 2046-0044 21.3 µM -0.42101961933328 0.346967421239309 no 2197 0.336870377763141 3137 3623589 SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM -0.421295617727217 0.34686650136719 no 2198 0.336769614922726 3106 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1 SGTC_2673 kobusone 100 µM -0.421518771604659 0.346784912237142 no 2199 0.336688153381661 3179 6710676 An epoxy ketone and protein crosslinker. SGTC_680 0417-1641 114 µM -0.421698617374716 0.34671916251155 no 2200 0.336622506889255 3097 2835990 SGTC_1861 st057647 17.4 µM -0.422022185851991 0.346600880898234 no 2201 0.336504411919192 3315 688668 SGTC_1979 st071809 45.3 µM -0.426237300436237 0.345061400620769 no 2202 0.334967470091147 3281 4976333 SGTC_2689 tacrolimus 100 µM -0.426353410507964 0.345019030034168 no 2203 0.334925172242021 3203 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). SGTC_2130 NSC 7 2.4545 µM -0.427671279517799 0.3445382529909 no 2204 0.334445231347073 3252 21448 SGTC_952 1185-0122 232 µM -0.430900567616624 0.343361226056611 no 2205 0.333270335361957 3149 678600 SGTC_2708 st078559 56 µM -0.43168458129433 0.34307569337876 no 2206 0.332985337616428 3263 17250902 SGTC_1486 3970-0793 4.53 µM -0.431804005602166 0.343032207681195 no 2207 0.332941934004478 3245 2844330 SGTC_1252 0493-0875 34.8 µM -0.432086683253257 0.342929285205669 no 2208 0.332839206460422 3138 3960963 SGTC_2947 9072639 7.68 µM -0.432647388177278 0.342725167941509 no 2209 0.332635478492298 3239 16488146 SGTC_2674 ligustilide 100 µM -0.433868297759987 0.342280870719629 no 2210 0.332192041085741 3247 5319022 A signalling regulator. SGTC_2103 5378138 10 µM -0.434678780293827 0.341986051133146 no 2211 0.331897801461936 3277 244142 SGTC_843 0310-0051 143 µM -0.434866368935033 0.341917827965455 no 2212 0.331829713572891 3208 2065037 SGTC_2459 5811157 9.22 µM -0.436603511743217 0.341286300718471 no 2213 0.331199457706479 3241 2870684 YBR192W RIM2 SGTC_66 0109-0187 42.4 µM -0.436848100302479 0.341197417736798 no 2214 0.331110756437213 3270 759417 SGTC_766 1391-0721 126 µM -0.437220745367156 0.341062016221023 no 2215 0.330975633053276 3295 1020919 YIL115C NUP159 SGTC_974 1326-0144 138 µM -0.439373309467889 0.340280277699218 no 2216 0.330195531440316 3201 5411856 SGTC_1182 1222-0449 220 µM -0.439664220806094 0.340174681076094 no 2217 0.330090160000223 3239 658318 SGTC_2650 prasterone 100 µM -0.439820893588425 0.340117816306354 no 2218 0.330033416895341 3230 16759247 A steroid and weak partial agonist of the androgen receptor. SGTC_2300 7976697 71.57 µM -0.43998604809047 0.340057877012808 no 2219 0.329973606149219 3122 2236109 SGTC_3230 9131665 49.47 µM -0.440017663130153 0.340046403471374 no 2220 0.329962157249889 3204 15943720 SGTC_2090 5301565 104.445 µM -0.440978962149953 0.339697605344509 no 2221 0.329614113715958 3183 2056344 SGTC_598 3937-0236 20.2 µM -0.441103097938535 0.3396525738628 no 2222 0.329569180427691 3244 1379313 SGTC_2107 5363541 170.161 µM -0.441945847061045 0.33934691884743 no 2223 0.329264196577212 3282 244052 SGTC_1499 4480-0877 67.3 µM -0.44290006731681 0.339000962147972 no 2224 0.328919009362695 3216 2861909 SGTC_170 4197-0004 226 µM -0.443298322277719 0.338856613209691 no 2225 0.328774984575401 3290 218692 SGTC_3286 9117135 37.221 µM -0.443579626124528 0.338754667878943 no 2226 0.328673269269448 3173 3438150 SGTC_3176 9106582 49.47 µM -0.444895646507855 0.338277895253181 no 2227 0.328197584459595 3215 17018027 SGTC_1871 st057448 67.3 µM -0.445809335615018 0.337947033046998 no 2228 0.327867488834164 3381 691747 SGTC_1935 st074532 41.6 µM -0.445886560945417 0.337919074187579 no 2229 0.327839595191892 3276 2829742 SGTC_2136 5328288 199.296 µM -0.446517651461824 0.337690626058815 no 2230 0.327611682506886 3179 262395 SGTC_2142 5622915 118.518 µM -0.446710725167042 0.337620747348616 no 2231 0.327541968493024 3223 5322196 SGTC_543 3844-1095 191 µM -0.446913939274779 0.337547204593346 no 2232 0.327468599531663 3266 4230703 SGTC_3169 9102970 49.47 µM -0.447387828761283 0.337375729098688 no 2233 0.327297531102595 3289 17027839 SGTC_2716 st080858 38.6235 µM -0.447487124250941 0.337339803600594 no 2234 0.32726169121444 3304 5296050 SGTC_2643 anethole 100 µM -0.447834501511596 0.337214132813774 no 2235 0.327136320789207 3252 637563 An anti-fungal, anti-helmenthic and channel blocker. SGTC_1219 1469-0211 33.1 µM -0.447916496177813 0.337184472225025 no 2236 0.327106731293181 3282 6822282 SGTC_530 4358-1714 28 µM -0.448636154069604 0.336924188037727 no 2237 0.326847074283516 3257 1564641 SGTC_752 1896-0090 130 µM -0.449493360438072 0.33661425752221 no 2238 0.326537898325821 3233 772567 SGTC_1151 3909-8316 15.3 µM -0.449963562067928 0.336444299087138 no 2239 0.326368357252589 3305 800431 SGTC_914 3820-6779 408 µM -0.450182327482978 0.336365235827766 no 2240 0.326289489011249 3149 2893481 SGTC_2864 9034755 47.6 µM -0.45019089130935 0.336362140951755 no 2241 0.326286401780252 3300 4930451 SGTC_2357 9067248 200 µM -0.450558590029786 0.33622926899553 no 2242 0.326153858840414 3280 9150235 SGTC_3333 9141820 12.094 µM -0.451851151694871 0.335762350130362 no 2243 0.325688108468139 3173 1939433 SGTC_3271 9137798 49.47 µM -0.453263382868738 0.335252492118161 no 2244 0.32517954832395 3274 6498326 SGTC_1967 st070177 51.4 µM -0.453643001660254 0.335115489985119 no 2245 0.325042898840508 3347 5729214 SGTC_3142 9086498 49.47 µM -0.455044371717935 0.334609934026259 no 2246 0.324538658531136 3262 25236367 SGTC_2283 7944793 200 µM -0.45540475187957 0.334479972281779 no 2247 0.324409038641639 3257 2970533 SGTC_1549 4'-methoxyflavonol 74.6 µM -0.455555323144143 0.334425678539538 no 2248 0.32435488815693 3268 97141 SGTC_2062 5245942 200 µM -0.456544674240498 0.334069019533606 no 2249 0.323999176694355 3290 1376160 SGTC_2539 epi(13)torulosol 80 µM -0.45690053574798 0.333940768816866 no 2250 0.323871269452924 3289 6708597 SGTC_1078 idebenone 36.1 µM -0.457592497313046 0.333691444838492 no 2251 0.323622617366821 3274 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen. SGTC_2558 carylophyllene oxide 100 µM -0.458390217651389 0.333404105524039 no 2252 0.323336059215532 3306 6708694 An oxygenated terpenoid and antifungal agent. SGTC_1274 0865-0114 173 µM -0.458449077482192 0.333382908049286 no 2253 0.323314919658033 3243 870624 SGTC_2747 doxorubicin 7.63 µM -0.459981297509948 0.332831289638175 no 2254 0.322764822421318 3207 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_1391 3442-0225 151 µM -0.460652641140417 0.332589711382276 no 2255 0.322523918853785 3175 5227075 SGTC_3197 9113331 49.47 µM -0.460977601937001 0.332472801497275 no 2256 0.322407337339196 3390 16610459 YLR208W | YDL195W SEC13 | SEC31 SGTC_2763 lisinopril 49.32 µM -0.462034493010788 0.332092680626945 no 2257 0.322028292524542 3310 5362119 A lysine-analog of enalapril and an ACE inhibitor. SGTC_1937 st074714 47.2 µM -0.462209423846911 0.33202978174611 no 2258 0.321965572937792 3191 17250970 SGTC_1539 benzyladenosine 56 µM -0.462341942580056 0.331982135893259 no 2259 0.321918063134244 3211 92208 A nucleotide analog. SGTC_1450 4112-4260 37.6 µM -0.464417403638122 0.331236278446627 no 2260 0.321174361764303 3331 1633175 SGTC_2361 9034121 116 µM -0.464431545324538 0.331231198647103 no 2261 0.321169296818996 3225 6496917 SGTC_1789 tunicamycin 25 nM -0.464753367638273 0.331115606061973 no 2262 0.321054042868301 3331 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_1386 3228-0095 33.8 µM -0.465530271867155 0.33083662286072 no 2263 0.320775881870159 3331 870181 SGTC_789 1309-1135 70.6 µM -0.465658575206802 0.33079055867724 no 2264 0.320729954112151 3307 3092424 SGTC_1959 st077091 55.8 µM -0.466643460318397 0.330437045074763 no 2265 0.32037749379309 3176 821356 YKL052C ASK1 SGTC_1574 spiramycin 23.7 µM -0.46719081498854 0.330240643545868 no 2266 0.320181682259345 3210 6419898 An antibiotic and protein synthesis inhibitor. SGTC_420 mitomycin C 81.9 mM -0.468139884213261 0.329900209861192 no 2267 0.31984227941315 3210 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_3069 9117009 49.47 µM -0.468933446250072 0.329615665119304 no 2268 0.319558604230335 3221 41904981 SGTC_2012 4023501 200 µM -0.469608393481336 0.329373729259773 no 2269 0.319317413419654 3261 3477460 SGTC_663 1486-0733 13.9 µM -0.474913473281666 0.327474608909598 no 2270 0.317424323872437 3230 722445 YPR165W RHO1 SGTC_2502 avocadyne acetate 18.59 µM -0.476083783451781 0.327056257730553 no 2271 0.317007344795569 3165 3952079 SGTC_1191 1487-1166 10.6 µM -0.477093105693605 0.326695629388067 no 2272 0.31664791190042 3332 3955771 SGTC_1416 3966-0321 25.3 µM -0.477676698793149 0.326487186841695 no 2273 0.31644016567265 3276 582530 YLR208W SEC13 SGTC_2007 4011539 71.82 µM -0.478479855061567 0.326200411268379 no 2274 0.316154354508543 3240 45595301 SGTC_989 1501-0895 10.3 µM -0.478561305383261 0.326171334291035 no 2275 0.316125375730271 3360 2830112 SGTC_888 0916-0002 6.97 µM -0.478959260837293 0.326029283238353 no 2276 0.315983805512616 3384 2802138 YIL048W NEO1 SGTC_504 lovastatin 124 µM -0.479257127501724 0.325922975610743 no 2277 0.315877858924156 3275 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1 SGTC_902 1120-0002 2.07 µM -0.480507158981281 0.325476997880377 no 2278 0.315433406954386 3311 3280475 SGTC_521 r062-0005 13.8 µM -0.481216060711179 0.325224191679717 no 2279 0.315181473641798 3286 2832033 SGTC_851 0394-0702 453 µM -0.481762974551538 0.32502920801447 no 2280 0.3149871671715 3373 762646 SGTC_2132 5317594 122.667 µM -0.482274281795616 0.324846962010784 no 2281 0.314805557240748 3201 794577 SGTC_1898 st060199 18.6 µM -0.482801926885016 0.324658936626884 no 2282 0.314618191259091 3241 688866 SGTC_2379 9035213 200 µM -0.483592144015314 0.324377427730007 no 2283 0.314337675609411 3372 646551 SGTC_289 k017-0060 526 µM -0.483735385407832 0.324326409801741 no 2284 0.314286838458006 3254 5512909 SGTC_342 k048-0088 23.3 µM -0.483814878877087 0.324298098234545 no 2285 0.314258627312011 3223 6820570 SGTC_17 0960-0276 49.807 µM -0.483970340547607 0.324242733558718 no 2286 0.314203459225314 3268 6821114 SGTC_1459 k035-0031 35.7 µM -0.484054693023656 0.324212694677315 no 2287 0.314173527122672 3201 3877128 YMR208W ERG12 SGTC_2936 9038235 15.59 µM -0.484111887275894 0.324192327800913 no 2288 0.314153232690752 3271 4749415 SGTC_512 prima-1 270 µM -0.484399741026764 0.324089831052032 no 2289 0.314051101092663 3380 322968 A re-activator of the apoptotic function of mutant p53. SGTC_3117 9124945 49.47 µM -0.484773423545368 0.323956792944837 no 2290 0.313918538366202 3193 17592065 SGTC_155 k072-0202 43.6 µM -0.485445327302177 0.32371763895197 no 2291 0.313680242982868 3331 5857737 SGTC_3251 9135047 49.47 µM -0.485574337482753 0.323671728052017 no 2292 0.313634497507489 3320 17682963 SGTC_157 1348-1695 65.819 µM -0.487288393017593 0.323062001382788 no 2293 0.31302698598861 3350 5380510 SGTC_3058 9093861 49.47 µM -0.488239633014024 0.322723829611156 no 2294 0.312690057413448 3397 17217477 SGTC_1581 himbacine 57.9 µM -0.488817277319199 0.322518544948868 no 2295 0.312485532515029 3254 5281825 An alkaloid muscarinic receptor antagonist. SGTC_1507 4075-3230 155 µM -0.489491311148973 0.32227907353081 no 2296 0.312246952250455 3312 659771 SGTC_379 3970-0972 5.9 µM -0.490721173423068 0.321842316903744 no 2297 0.31181183443943 3318 2898042 YBL034C STU1 SGTC_1671 st016596 74.5 µM -0.490741487517857 0.32183510489516 no 2298 0.311804649638469 3361 2829167 SGTC_2921 7974240 10.71 µM -0.491032346386544 0.321731850128618 no 2299 0.311701784927028 3355 2979074 YDR527W RBA50 SGTC_627 1391-0720 175 µM -0.493556584389579 0.320836325672666 no 2300 0.310809684368047 3306 997839 SGTC_648 0375-0473 33.3 µM -0.494253850264884 0.320589139859171 no 2301 0.310563456582666 3280 1713139 SGTC_689 0833-0039 98 µM -0.495025934392465 0.320315523238649 no 2302 0.310290906972244 3323 5374726 SGTC_3060 1327-0027 12.5 µM -0.496710210832255 0.319718976511159 no 2303 0.309696710430545 3292 16000455 YPR107C YTH1 SGTC_124 0136-0217 7.121 µM -0.496983262741596 0.319622309277763 no 2304 0.309600427115295 3456 3976905 SGTC_457 grayanotoxin iii 135 µM -0.49901139047045 0.318904685008522 no 2305 0.308885679843166 3363 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity. SGTC_2560 caryophyllene 100 µM -0.500084189806733 0.318525364293624 no 2306 0.308507899038048 3285 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor. SGTC_2930 9013230 14.89 µM -0.500203409011619 0.318483222462272 no 2307 0.30846592910791 3376 2995857 SGTC_57 miconazole 162.5 nM -0.501956419469015 0.31786383635681 no 2308 0.307849088484892 3324 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_1457 k015-0032 57.3 µM -0.502462808389119 0.317685010148545 no 2309 0.307671003798837 3362 4302660 SGTC_1543 azetidyl-2-carboxylic acid 198 µM -0.50272602639806 0.317592074121651 no 2310 0.307578454310493 3335 16486 A toxic proline analog. SGTC_318 1488-0629 67.2 µM -0.504245331636641 0.317055868320738 no 2311 0.307044494321072 3368 3662576 SGTC_1712 st032288 53.4 µM -0.504889166217379 0.316828756633852 no 2312 0.306818341893439 3389 2883011 SGTC_3190 9110366 49.47 µM -0.505197649775552 0.316719963968116 no 2313 0.306710010434897 3332 17123768 SGTC_1258 0671-0043 57.1 µM -0.505765477043743 0.316519750194941 no 2314 0.306510648305143 3328 4298767 SGTC_2168 5727979 200 µM -0.507072672974717 0.316059042178925 no 2315 0.306051914138148 3332 695210 SGTC_2850 9015429 58.44 µM -0.5130635343747 0.313951284625594 no 2316 0.30395343925794 3322 6457570 SGTC_822 1487-0950 154 µM -0.513600334304945 0.313762717582241 no 2317 0.303765722902426 3411 1958375 SGTC_2059 5238311 157 µM -0.514253754210387 0.31353324991995 no 2318 0.303537294936419 3268 703021 SGTC_1071 trifluoperazine 6.31 µM -0.5157135412687 0.313020863375396 no 2319 0.303027247784377 3434 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. SGTC_3160 9100216 49.47 µM -0.516641073582554 0.312695486153319 no 2320 0.302703368920889 3354 17191039 SGTC_1677 st019204 53.9 µM -0.521128362156247 0.311123414770788 no 2321 0.301138677206958 3348 3945625 SGTC_1022 4477-0945 21.3 µM -0.522363404099806 0.310691334034437 no 2322 0.300708665579836 3355 4648966 SGTC_63 0099-0242 26.702 µM -0.523165368764135 0.31041090555102 no 2323 0.300429589427249 3422 3898502 YLR359W ADE13 SGTC_1224 0823-0416 294 µM -0.524575290653069 0.309918155662843 no 2324 0.299939233784463 3428 3598164 SGTC_69 0096-0274 206.684 µM -0.525359124754453 0.309644363080606 no 2325 0.299666781483553 3554 6741392 SGTC_357 1325-0123 420 µM -0.525689204489431 0.309529098097378 no 2326 0.299552082875774 3403 1098503 SGTC_852 0418-0143 439 µM -0.526797058382209 0.309142368696298 no 2327 0.299167262947534 3420 5369229 SGTC_2198 6589944 200 µM -0.528360915496233 0.308596817659342 no 2328 0.298624429711319 3379 5290268 SGTC_706 4262-0057 46.9 µM -0.530210584158333 0.307952106404189 no 2329 0.297982966738848 3345 883298 SGTC_2351 9026858 72.31 µM -0.53030679295683 0.307918588535703 no 2330 0.297949618827503 3305 1409300 SGTC_1780 st038448 24.544 µM -0.530464851999484 0.307863526342016 no 2331 0.297894836066917 3457 728868 YDL195W SEC31 SGTC_931 2812-0076 566 µM -0.531909246706791 0.307360550715963 no 2332 0.297394426353952 3305 3450959 SGTC_187 1488-2104 32.728 µM -0.532353576866641 0.307205896232814 no 2333 0.297240565687348 3387 2852859 SGTC_472 calcifediol 10 µM -0.532843617485691 0.307035371427207 no 2334 0.297070918805617 3401 5283731 A vitamin D metabolite. SGTC_767 0929-0023 86 µM -0.533813136252433 0.306698120332734 no 2335 0.296735412184392 3448 1204563 SGTC_1355 1499-0035 1.68 µM -0.536347539489281 0.305817290988482 no 2336 0.295859190370941 3382 1548538 SGTC_2605 digitonin 300 nM -0.536767768351752 0.305671349181929 no 2337 0.295714019150405 3508 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_908 3448-7491 47.7 µM -0.53681940773854 0.305653417403671 no 2338 0.295696182194494 3384 1203031 SGTC_2022 5136654 200 µM -0.53720024422426 0.305521186320757 no 2339 0.295564651295472 3407 1713771 SGTC_1831 st055328 12 µM -0.537745378442797 0.305331953196862 no 2340 0.295376423109233 3436 1103068 SGTC_657 3534-0529 86.7 µM -0.538249813026434 0.305156894516577 no 2341 0.295202297153927 3431 1049549 SGTC_1166 k206-0078 225 µM -0.540173849549453 0.30448958746302 no 2342 0.294538572575568 3409 5404595 SGTC_905 2-aminofluorene 215 µM -0.542132096035551 0.30381108308195 no 2343 0.293863754737001 3460 1539 An established DNA mutagen. YPR165W RHO1 SGTC_926 2268-1401 59.4 µM -0.542597471485949 0.303649936397897 no 2344 0.293703490139917 3432 2931578 SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM -0.544026402751816 0.303155375531084 no 2345 0.293211652061392 3461 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_2327 6189656 200 µM -0.546532450710071 0.302288889858205 no 2346 0.292349993812578 3437 5349088 SGTC_2659 sanguinarine 24.21 µM -0.548004784514248 0.301780337690873 no 2347 0.291844308797132 3350 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis. SGTC_2270 7924575 90.91 µM -0.548311426673027 0.301674470216478 no 2348 0.291739041345416 3457 1262135 SGTC_186 3455-3465 67.277 µM -0.550627722628587 0.300875314721696 no 2349 0.290944450341407 3401 755278 SGTC_835 0312-0010 67.2 µM -0.551053949422156 0.300728364408454 no 2350 0.290798346117109 3387 1626196 SGTC_2430 5571206 200 µM -0.55153102467582 0.300563921484881 no 2351 0.290634852491906 3495 1731771 SGTC_2694 st077685 81.9 µM -0.552293008225261 0.300301357857401 no 2352 0.290373810057036 3356 2838096 SGTC_2121 5257820 149.641 µM -0.553183752784507 0.299994557368222 no 2353 0.290068795567668 3482 791256 SGTC_1061 3448-9325 110 µM -0.553218524302637 0.299982583838614 no 2354 0.290056891926617 3454 723482 SGTC_2084 5306078 60.6385 µM -0.553735441167934 0.299804609659033 no 2355 0.289879958218269 3344 679340 SGTC_2477 5967686 25.23 µM -0.555383624258571 0.29923746068524 no 2356 0.289316145546687 3362 776118 SGTC_3277 9138724 49.47 µM -0.555647191190213 0.299146811003294 no 2357 0.289226032034114 3353 15943418 SGTC_2184 6075246 200 µM -0.555879526057984 0.299066913433921 no 2358 0.289146607704758 3422 2267320 SGTC_310 1273-0058 1.06 µM -0.557588323142789 0.298479573620305 no 2359 0.288562765940668 3469 2734232 SGTC_2853 9015042 58.44 µM -0.559185412527505 0.297931104416491 no 2360 0.288017593819418 3347 6457456 SGTC_1399 3562-5772 25 µM -0.560218517146955 0.297576562633885 no 2361 0.287665199056479 3412 23847490 SGTC_983 1491-0821 12.2 µM -0.560496194133608 0.29748130204179 no 2362 0.287570517445337 3451 46495113 SGTC_1847 st056231 15 µM -0.566245597583748 0.295512033857366 no 2363 0.285613418503412 3459 5393180 SGTC_922 1866-0035 480 µM -0.56692509315718 0.295279691758724 no 2364 0.285382537441123 3431 3156169 SGTC_3212 9128307 49.47 µM -0.567963104479128 0.294924923632116 no 2365 0.28503001051523 3262 27243542 SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM -0.569362137156276 0.294447077827393 no 2366 0.284555203159278 3584 16725076 SGTC_2117 5521686 200 µM -0.570025205664173 0.294220728740785 no 2367 0.284330301254178 3416 803312 SGTC_1375 2910-0797 186 µM -0.570431111530076 0.294082205930376 no 2368 0.284192666611003 3400 742508 SGTC_1696 st025591 34.7925 µM -0.571440088343753 0.293738004773876 no 2369 0.283850680628582 3474 2787147 SGTC_3263 9137018 49.47 µM -0.571662493704848 0.293662158755317 no 2370 0.283775324316329 3427 43844957 SGTC_1953 st076800 12.1 µM -0.572430835448001 0.293400203997404 no 2371 0.283515065295449 3402 297591 SGTC_2499 avocadenofuran 51.48 µM -0.573730258736604 0.292957431382815 no 2372 0.283075174464923 3345 6857792 A insecticide and lysyl oxidase inhibitor. SGTC_146 3448-8650 53.125 µM -0.573790489136826 0.292936915667191 no 2373 0.283054792749517 3449 2891488 YIL048W NEO1 SGTC_3119 9125183 49.47 µM -0.574131716848911 0.292820699066335 no 2374 0.282939336020241 3345 22695334 SGTC_1860 st056228 74.6 µM -0.574365849864146 0.292740969559248 no 2375 0.282860128596566 3460 688679 SGTC_2729 fluphenazine 10.66 µM -0.574767240019565 0.292604307302645 no 2376 0.282724362705196 3393 3372 An atypical antipsychotic. SGTC_3291 9121177 71.43 µM -0.576923814708841 0.291870561166879 no 2377 0.281995461099306 3419 17015612 SGTC_2197 6588183 93.1375 µM -0.578724690321289 0.291258494411582 no 2378 0.281387476701369 3452 884136 SGTC_579 4491-1009 110 µM -0.579842749195943 0.29087879948449 no 2379 0.281010333133637 3583 1271041 SGTC_996 3970-0799 1.8 µM -0.580111178422582 0.290787674859336 no 2380 0.280919822972986 3535 6615648 YGL040C HEM2 SGTC_1899 st063254 59.6 µM -0.580241365073726 0.290743484740366 no 2381 0.280875931133595 3432 3093813 SGTC_3193 9111931 49.47 µM -0.581290117769768 0.290387614250216 no 2382 0.28052246989049 3453 17087244 SGTC_1664 st014217 9.02 µM -0.582111363243302 0.290109085644346 no 2383 0.280245835808138 3549 3982782 SGTC_2400 5203494 178.7 µM -0.587732306865169 0.288206090143438 no 2384 0.278355993523633 3484 6777674 SGTC_1854 st056233 32.9 µM -0.587737677263181 0.288204274790283 no 2385 0.278354190892605 3471 5393174 SGTC_3204 9114183 49.47 µM -0.58784329434309 0.288168574193851 no 2386 0.278318740556336 3464 17027248 SGTC_1495 4469-0029 237 µM -0.588112659977363 0.288077532896143 no 2387 0.278228338039701 3496 793680 SGTC_1558 st069300 45.6 µM -0.588215657260197 0.288042725041427 no 2388 0.278193774632212 3478 24208000 SGTC_1170 0310-0127 64.8 µM -0.588284027958381 0.288019620311357 no 2389 0.278170832228892 3438 774975 SGTC_1160 4092-0570 10.5 µM -0.589198546996715 0.287710658089312 no 2390 0.277864045878532 3500 4994975 SGTC_271 rotenone 740 µM -0.589532633404842 0.287597828999463 no 2391 0.277752013801676 3538 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria. SGTC_655 k060-0012 42 µM -0.591281922350735 0.287007393394744 no 2392 0.277165770042386 3437 5994525 SGTC_245 methotrexate 289.6 µM -0.591980211453439 0.286771861072205 no 2393 0.276931919781872 3480 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2 SGTC_2814 7977482 42.97 µM -0.593537192155136 0.286247022963302 no 2394 0.276410850120841 3547 6456762 SGTC_2380 9035439 200 µM -0.594803266516585 0.285820582167733 no 2395 0.275987491920013 3584 6462575 SGTC_422 cantharidin 155 µM -0.596240748885663 0.285336774054349 no 2396 0.275507203553056 3493 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_449 xestospongin c 11.1929 µM -0.596715408120753 0.285177105466749 no 2397 0.275348701815072 3492 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1 SGTC_1576 erythromycin ethylsuccinate 23.2 µM -0.597292782652871 0.284982942338971 no 2398 0.275155961132604 3523 3256 An antibiotic and ribosome inhibitor. SGTC_1707 st032323 6.317 µM -0.597897163979511 0.28477976475685 no 2399 0.274954276164703 3459 3132057 YMR211W DML1 SGTC_3041 9091929 49.47 µM -0.598771730892278 0.284485880120718 no 2400 0.274662557985114 3595 25236887 SGTC_1443 4112-3303 14 µM -0.599326087834036 0.284299672124247 no 2401 0.274477727254024 3505 704433 SGTC_283 0987-0079 11.7 µM -0.599870153052567 0.284116977771742 no 2402 0.274296387632964 3534 411556 SGTC_2891 9063876 19.48 µM -0.599961648141833 0.284086259699062 no 2403 0.274265897679818 3461 6472478 SGTC_1870 st057514 26.5 µM -0.600490784357967 0.283908641497612 no 2404 0.274089600410557 3478 5393161 SGTC_812 4251-0442 148 µM -0.600916019355273 0.283765938947279 no 2405 0.273947961473252 3526 5723007 SGTC_2151 5563267 85.4165 µM -0.601118399926198 0.283698035097743 no 2406 0.273880564469519 3472 5310824 SGTC_1902 st060212 70.5 µM -0.602243702166838 0.283320609468456 no 2407 0.273505964643172 3549 688944 SGTC_3013 9080133 71.4286 µM -0.602896040880024 0.283101925800618 no 2408 0.273288924971357 3600 17050193 SGTC_1158 4092-0494 91.8 µM -0.60361351630341 0.2828614999147 no 2409 0.273050312212247 3566 1148199 SGTC_3222 9128301 49.47 µM -0.603676294083111 0.28284046775838 no 2410 0.273029438949087 3482 4911358 SGTC_2424 5537928 59.2 µM -0.604609138905128 0.282528029504688 no 2411 0.272719366462355 3502 5382802 SGTC_1127 asiatic acid 681.4 nM -0.604632448817401 0.282520224427872 no 2412 0.272711620613996 3478 470603 A kinase inhibitor which arrests cells at G2/M. SGTC_2574 2',4'-dihydroxychalcone 14.64 µM -0.60503891455216 0.282384140357342 no 2413 0.272576570220545 3561 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM -0.60539554657592 0.282264766507764 no 2414 0.272458104692014 3551 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_349 k015-0014 24 µM -0.605960387565848 0.282075749501358 no 2415 0.272270528932179 3460 2196908 SGTC_415 dibenzyl ketone 100 µM -0.606506107224466 0.281893189117772 no 2416 0.272089364065564 3500 7593 SGTC_1432 4049-0298 68.4 µM -0.6072908412365 0.281630770747475 no 2417 0.27182895769 3540 741646 SGTC_1545 lovastatin 49.4 µM -0.607419556473587 0.281587739076598 no 2418 0.27178625662773 3523 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12 SGTC_3232 9132874 49.47 µM -0.608425904940213 0.281251409201841 no 2419 0.271452517345538 3482 3784940 SGTC_2036 5160441 105 µM -0.609714825880604 0.280820924799139 no 2420 0.271025365852374 3537 134534 YIL048W NEO1 SGTC_2595 hexamethylquercetagetin 100 µM -0.609875436574136 0.280767305050999 no 2421 0.270972162585638 3457 386331 SGTC_339 3091-4833 71.4 µM -0.610862359889069 0.280437930241633 no 2422 0.270645352675705 3525 3240077 SGTC_1365 1672-3266 55.4 µM -0.61307822139308 0.2796990930238 no 2423 0.26991230989192 3546 6415873 SGTC_249 wiskostatin 11.211 µM -0.613436014686888 0.279579882234692 no 2424 0.269794039348014 3547 2775510 A n-wasp and actin depolymerizer. SGTC_439 amiodarone 34.4 µM -0.614808631542893 0.279122778033057 no 2425 0.269340554156717 3469 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1 SGTC_611 3453-1652 23.7 µM -0.615349772649741 0.278942668974373 no 2426 0.269161877047538 3544 1560575 SGTC_686 1319-0111 510 µM -0.615443017610708 0.27891163978191 no 2427 0.269131094892993 3601 4562600 SGTC_2832 7992762 51.95 µM -0.615619634565189 0.2788528714346 no 2428 0.269072794703257 3373 2985177 SGTC_2960 9079389 5.97 µM -0.615718096494057 0.27882011137038 no 2429 0.269040295767103 3538 16457355 SGTC_2861 9024595 19.48 µM -0.616332479148114 0.278615737468822 no 2430 0.268837553443979 3475 16482810 SGTC_304 1310-0298 97 µM -0.617207515223675 0.278324783416942 no 2431 0.268548929691021 3502 1550234 SGTC_404 fumagillin 50 µM -0.6172350997934 0.278315613812396 no 2432 0.268539833671123 3494 12015870 A methionine aminopeptidase binder. SGTC_2772 vinpocetine 57.06 µM -0.618286625469549 0.277966177707391 no 2433 0.268193208287719 3594 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor. SGTC_1440 4100-1550 40 µM -0.618528763922164 0.277885742185619 no 2434 0.268113421565078 3556 742806 SGTC_58 0957-0393 9 µM -0.620061247140338 0.27737693310458 no 2435 0.267608732275549 3529 6997992 SGTC_513 4245-1575 41.7 µM -0.620269192419352 0.277307927040141 no 2436 0.267540287037623 3538 719745 SGTC_12 0849-0099 9.267 µM -0.620918489534478 0.277092513641797 no 2437 0.267326627561474 3501 6071388 SGTC_3135 9127742 49.47 µM -0.623119061599124 0.276363052743437 no 2438 0.266603142209763 3497 3643468 SGTC_2347 9049783 174.81 µM -0.624205634331087 0.276003215787971 no 2439 0.266246273550245 3559 6467988 YPL169C MEX67 SGTC_502 l-744,832 89.3 µM -0.625050556697494 0.275723564553144 no 2440 0.265968938576005 3538 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.  SGTC_1719 st032227 49.2 µM -0.627052128526794 0.27506164334707 no 2441 0.265312532714454 3570 3125804 SGTC_1337 1486-1011 40.3 µM -0.627414305953148 0.274941954698321 no 2442 0.265193846289722 3587 X1337 SGTC_333 3486-0131 40.1 µM -0.633206791380037 0.273031208832613 no 2443 0.263299305670652 3638 6744690 SGTC_2536 dehydroabietamide 32.04 µM -0.634412450752472 0.272634331650644 no 2444 0.262905843075719 3590 3983547 SGTC_1805 st050013 60.3 µM -0.634984053427367 0.272446272428322 no 2445 0.262719407703613 3527 4037144 SGTC_2208 7283366 200 µM -0.636709559135956 0.271878966245793 no 2446 0.262157022931641 3589 898663 SGTC_1315 1237-0019 3.69 µM -0.637103774787377 0.271749439819767 no 2447 0.262028624970787 3576 825140 SGTC_2047 4141938 200 µM -0.637297338095438 0.27168585246404 no 2448 0.261965592259166 3543 3807862 SGTC_2267 7931562 200 µM -0.637538747007898 0.271606557760888 no 2449 0.261886989813623 3501 934880 SGTC_3302 9125395 16.351 µM -0.638588476705525 0.271261890939763 no 2450 0.261545339809818 3530 17599668 SGTC_1434 4073-0095 163 µM -0.638769742372708 0.271202396498537 no 2451 0.26148636740066 3577 24133745 SGTC_2748 diazoxide 86.69 µM -0.639589240560907 0.270933504622817 no 2452 0.261219839634496 3519 3019 A potassium channel activatior. SGTC_285 1486-1325 46 µM -0.641755287401831 0.270223427362315 no 2453 0.260516042657585 3599 22310230 SGTC_2570 licareol 100 µM -0.642637523886332 0.269934478008994 no 2454 0.260229664410549 3526 443158 SGTC_1121 fusaric acid 630.51 nM -0.645307960393498 0.269060802439644 no 2455 0.259363817538828 3571 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler. SGTC_1585 2',4'-dihydroxychalcone 10.4 µM -0.645401969430525 0.269030071773682 no 2456 0.259333363736199 3616 5357218 A potent inhibitor of glutathione S-transferases. SGTC_1426 4048-4480 71.7 µM -0.646002557116418 0.268833786920706 no 2457 0.259138849684835 3587 14224343 SGTC_268 camptothecin 39.6153 µM -0.646041144057773 0.268821178345376 no 2458 0.259126355000965 3610 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_2743 auranofin 4.32 µM -0.647205691222719 0.26844079353213 no 2459 0.258749414217297 3546 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold. SGTC_2573 2',4'-dihydroxychalcone 15.04 µM -0.647742293179958 0.268265610321872 no 2460 0.258575822383634 3567 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_728 3030-5151 22.5 µM -0.648130689543961 0.268138847342248 no 2461 0.258450212996493 3616 3125388 SGTC_1609 st001574 46.4 µM -0.649909242169827 0.267558757055793 no 2462 0.257875423941014 3562 3960012 SGTC_967 1306-0166 352 µM -0.650283327844948 0.267436826370004 no 2463 0.257754612170041 3586 4437607 SGTC_95 0471-0001 561.058 µM -0.651524170094959 0.267032583018478 no 2464 0.257354089949683 3542 4015405 SGTC_3296 9122258 64.045 µM -0.653684083408882 0.266329660176533 no 2465 0.256657679892475 3599 4730474 SGTC_2479 5617353 43.85 µM -0.654443485295682 0.26608274287066 no 2466 0.256413063101287 3636 2731746 SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM -0.654920403193357 0.265927733697023 no 2467 0.256259501531745 3564 2724278 An inhibitor of dopamine biosynthesis. SGTC_1115 galangin 695.678 nM -0.655602220769922 0.265706206953489 no 2468 0.256040048133505 3645 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_1340 1486-1359 257 µM -0.65736880171698 0.265132669484913 no 2469 0.255471903473883 3576 4309068 SGTC_979 1426-2828 121 µM -0.659177970820866 0.264545957750516 no 2470 0.254890745613705 3657 747872 SGTC_3303 9125618 40.5795 µM -0.659447508115054 0.264458603647292 no 2471 0.254804221635126 3625 22695467 SGTC_552 k242-0005 476 µM -0.659531041607089 0.264431534331723 no 2472 0.254777409728433 3632 4088318 SGTC_2997 9067075 71.4286 µM -0.660097387771772 0.264248045106916 no 2473 0.254595667464726 3588 27209819 SGTC_2791 5663188 71.43 µM -0.660143621094847 0.26423306893922 no 2474 0.254580834044724 3589 54690634 SGTC_259 usnic acid 108.925 µM -0.661359458309271 0.263839383066794 no 2475 0.254190909471929 3685 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_3085 9117376 49.47 µM -0.661478660343752 0.263800801769227 no 2476 0.254152697697367 3631 16480349 SGTC_594 1487-1584 10.8 µM -0.663139304741497 0.263263611866089 no 2477 0.253620669864415 3594 5013332 SGTC_1021 4476-0760 85.3 µM -0.664367978742895 0.26286651687191 no 2478 0.253227411110409 3589 746768 SGTC_1104 tacrolimus 29.8 µM -0.666135756334444 0.262295726871363 no 2479 0.252662165803055 3665 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41 SGTC_3042 9091578 49.47 µM -0.666154625110637 0.262289637840459 no 2480 0.252656136115093 3588 25236497 SGTC_1942 st076330 65.2 µM -0.668037741109381 0.261682313041424 no 2481 0.252054750797856 3667 24208414 SGTC_448 monastrol 171 µM -0.670048367839877 0.261034662158258 no 2482 0.251413478718236 3570 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity SGTC_2640 pentamidine 10.38 µM -0.671218321285694 0.260658183486589 no 2483 0.251040729397591 3643 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_935 2996-0153 430 µM -0.673601328020921 0.259892222313399 no 2484 0.250282404321128 3635 23738523 SGTC_2185 6113692 200 µM -0.675186354298666 0.259383396828113 no 2485 0.24977868754982 3628 874150 SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM -0.675686541087275 0.259222933650863 no 2486 0.249619841440192 3628 6312947 SGTC_965 1291-5240 308 µM -0.67637834927053 0.259001081669108 no 2487 0.249400229902493 3629 2834598 SGTC_2321 7390090 138.78 µM -0.676750996357184 0.258881620327908 no 2488 0.249281977255861 3579 649046 SGTC_2034 5197015 53.07 µM -0.679766674064275 0.257915919307653 no 2489 0.248326105649761 3649 780676 SGTC_2710 st078562 53.7235 µM -0.680372192583668 0.257722241567823 no 2490 0.248134411834042 3620 17250908 SGTC_720 r052-1644 49.9 µM -0.680675250057031 0.257625335670306 no 2491 0.248038500163855 3629 1422863 YOR257W CDC31 SGTC_626 0214-0009 33 µM -0.680970566914415 0.257530923123399 no 2492 0.247945057276314 3674 3437874 SGTC_2726 cimetidine 79.27 µM -0.68102426368727 0.257513758242114 no 2493 0.247928068793536 3647 2756 A P450 inhibitor, histamine H2-receptor antagonist. SGTC_3093 9117344 49.47 µM -0.682590091383319 0.257013482228453 no 2494 0.247432948504654 3639 24824913 SGTC_2511 berberine 10.47 µM -0.684287428815622 0.256471760941907 no 2495 0.246896841798784 3653 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_2429 5902844 64.44 µM -0.685514322264651 0.256080557031818 no 2496 0.246509713007697 3675 1927790 YGL093W | YPR107C SPC105 | YTH1 SGTC_1240 0356-0016 42.1 µM -0.685613512346832 0.256048943155615 no 2497 0.246478429202572 3637 4305613 SGTC_2587 piperic acid 92.2 µM -0.686690025412037 0.255705967757739 no 2498 0.24613904195802 3630 5370536 SGTC_2189 6047310 154.431 µM -0.687599086719885 0.25541652915201 no 2499 0.245852641748848 3601 711535 SGTC_797 k781-0471 270 µM -0.687677784308489 0.255391480458447 no 2500 0.245827856450415 3654 23738129 SGTC_2289 7946404 165.07 µM -0.68824583566642 0.255210713201584 no 2501 0.245648992123682 3703 1246120 YPR165W RHO1 SGTC_3297 9117502 71.43 µM -0.688573135956322 0.255106588964662 no 2502 0.245545965676748 3643 7453720 SGTC_3262 9137218 49.47 µM -0.689560381559086 0.254792650573071 no 2503 0.245235344591923 3532 17650664 SGTC_403 arphamenine a 50 µM -0.690310333246689 0.254554305517716 no 2504 0.244999525525392 3619 5487158 An arginine aminopeptidase inhibitor. SGTC_2540 epiandrosterone 100 µM -0.692372537048488 0.25389951118522 no 2505 0.244351703905209 3735 441302 A steroid. SGTC_2711 st079103 59.1 µM -0.692457521666164 0.253872545708679 no 2506 0.244325026620274 3658 54693780 SGTC_1824 st053723 68.6 µM -0.692460083235583 0.253871732950339 no 2507 0.244324222549515 3635 675225 SGTC_2765 myclobutanil 7.74 µM -0.693015286985364 0.253695605023526 no 2508 0.244149979027419 3679 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11 SGTC_799 1310-0557 151 µM -0.694297519404482 0.253289086307704 no 2509 0.243747823159901 3684 5354492 SGTC_1045 1348-1485 165 µM -0.695521074317539 0.25290149025843 no 2510 0.243364404410295 3689 6810614 SGTC_1958 st076513 41.9 µM -0.697401751663075 0.252306341097461 no 2511 0.242775702817215 3648 732122 YGL099W LSG1 SGTC_1018 4259-0013 28.1 µM -0.69768218937083 0.252217658574812 no 2512 0.242687984504422 3697 6801262 SGTC_2346 9031566 143.75 µM -0.698532830138943 0.251948761916931 no 2513 0.242422016953034 3650 4771086 SGTC_43 0570-0105 72.5 µM -0.69854207487165 0.251945840389188 no 2514 0.242419127295101 3705 1114046 YDL195W SEC31 SGTC_114 0364-0001 490.298 µM -0.698891389988515 0.251835462651601 no 2515 0.242309954341327 3681 4003655 SGTC_2816 7982706 58.44 µM -0.69923982657042 0.251725387953412 no 2516 0.242201082508902 3674 2981853 SGTC_3228 9131799 49.47 µM -0.700781367812101 0.251238704241189 no 2517 0.241719733787748 3659 17015818 SGTC_3150 9097574 49.47 µM -0.700817044687133 0.251227446502755 no 2518 0.241708599777349 3652 17217476 SGTC_3226 9131256 49.47 µM -0.702179958727185 0.250797582597954 no 2519 0.241283471175168 3585 17178073 SGTC_2406 ethylparaben 405.7 µM -0.702310282631533 0.250756498769011 no 2520 0.241242841029907 3641 8434 A possible steroid mimic. SGTC_2466 5983409 37.09 µM -0.703275259051456 0.250452406658907 no 2521 0.240942113008317 3679 2879657 SGTC_3236 9132701 49.47 µM -0.703666330292861 0.250329224420906 no 2522 0.240820296530672 3676 24282524 SGTC_904 1141-0088 396 µM -0.704168518213111 0.250171089024773 no 2523 0.240663916993324 3633 1378119 SGTC_319 1348-1596 45.5 µM -0.705090195452108 0.249880997342537 no 2524 0.240377053841301 3740 5380505 SGTC_1785 bathophenanthroline 24 µM -0.705341919259046 0.249801800029132 no 2525 0.240298739628488 3641 72812 An iron chelator. SGTC_320 4092-0846 5.34 µM -0.706065590476996 0.249574192926659 no 2526 0.240073674519997 3658 1359356 SGTC_910 3454-3003 490 µM -0.706379986179791 0.24947534438659 no 2527 0.239975931817252 3619 820824 SGTC_2131 toluylene red 5.2905 µM -0.706565340669986 0.249417077192701 no 2528 0.239918316998259 3687 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain. SGTC_134 0269-0018 6.916 µM -0.706886786151724 0.249316046205145 no 2529 0.239818418110215 3620 4378915 SGTC_1616 st002734 56.1 µM -0.70758748280698 0.249095891206989 no 2530 0.239600734139297 3665 4026101 SGTC_20 0481-0013 4.944 µM -0.708124722575625 0.24892716352459 no 2531 0.239433904057337 3682 182045 SGTC_2507 purpurin 79.67 µM -0.708463417647284 0.248820822857994 no 2532 0.239328761046809 3689 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1 SGTC_921 1561-0023 372 µM -0.708653510394711 0.248761149713122 no 2533 0.239269760541113 3678 24050882 SGTC_2950 9072895 21.46 µM -0.708763789674474 0.248726534781503 no 2534 0.239235535980039 3641 17332245 SGTC_2760 etidronate 98.04 µM -0.710639978195209 0.248138021938702 no 2535 0.23865368135738 3693 3305 A chelator and antioxidant. SGTC_64 000l-0018 272.079 µM -0.711597462187051 0.247837969934435 no 2536 0.238357039503183 3639 6811119 SGTC_2493 resveratrol 26.09 µM -0.711786246375049 0.247778832466441 no 2537 0.238298575378167 3615 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase. SGTC_232 clozapine 119 µM -0.712482122472599 0.247560911336915 no 2538 0.238083139022571 3660 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_1541 2',3',6-trimethoxyflavone 64 µM -0.712771127823413 0.247470436285979 no 2539 0.237993697206464 3763 688801 SGTC_1271 0832-2808 169 µM -0.712784688288469 0.247466191526049 no 2540 0.237989500945543 3710 3663794 SGTC_1458 k015-0034 6.33 µM -0.713131670444365 0.247357590791363 no 2541 0.237882141754709 3713 3598957 SGTC_179 1273-0063 6.77 µM -0.713969142834204 0.247095578210213 no 2542 0.237623130204309 3693 3108139 SGTC_135 0933-0004 26.348 µM -0.714035993379976 0.247074669671245 no 2543 0.237602461491451 3678 21230617 YGL099W LSG1 SGTC_2497 7-hydroxyflavone 100 µM -0.714334993478113 0.246981164364576 no 2544 0.237510029337272 3674 5281894 SGTC_524 r073-0010 27.8 µM -0.714754098339315 0.246850130972893 no 2545 0.237380501520011 3644 2772106 SGTC_2909 7941780 10.49 µM -0.715618305919231 0.246580053463133 no 2546 0.23711353352183 3696 1243215 SGTC_2381 9035592 200 µM -0.71651228388786 0.246300838916935 no 2547 0.236837542639933 3693 4749657 SGTC_1301 naphtanilide LB 4.81 µM -0.717079757400789 0.246123688906844 no 2548 0.236662442634963 3743 67238 An a1-adrenergic receptor antagonist or alpha blocker. SGTC_1131 3454-3128 32.3 µM -0.717988511378303 0.245840142693104 no 2549 0.236382185298794 3774 710982 SGTC_2405 ticlatone 3.52 µM -0.718119270917617 0.245799357996935 no 2550 0.236341874442087 3630 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W SGTC_386 1509-0011 3.07 µM -0.718952788647447 0.245539464136646 no 2551 0.236085004623717 3738 3107280 SGTC_41 0478-0632 82.643 µM -0.719401186111481 0.245399713267829 no 2552 0.235946883124246 3691 3750424 SGTC_1692 fluoroquinolonic acid 71 µM -0.720009273698956 0.245210260506256 no 2553 0.23575964286887 3715 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2 SGTC_683 panaxydol 45 µM -0.722563366822341 0.244415379456521 no 2554 0.234974090711108 3685 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis. SGTC_714 4296-0578 26.1 µM -0.722880356997056 0.244316823193138 no 2555 0.234876696302865 3730 1589775 SGTC_435 c-PAF 6.7 µM -0.723021182878237 0.24427304551445 no 2556 0.234833435075127 3738 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase SGTC_168 3970-0862 530.542 µM -0.723185631167396 0.244221929834957 no 2557 0.23478292269957 3713 3135186 SGTC_2843 9000894 45.46 µM -0.723565778672808 0.244103790158899 no 2558 0.234666178570584 3613 2242070 SGTC_2553 4-methylesculetin 85.09 µM -0.725951424844663 0.243363099257418 no 2559 0.23393427473218 3763 5319502 SGTC_2773 thioridazine 9.09 µM -0.726179032227313 0.243292495667973 no 2560 0.233864512118446 3727 5452 An antipsychotic. SGTC_468 gf-109203x 121 µM -0.726983012631777 0.243043190370764 no 2561 0.23361818106934 3659 2396 A protein kinase C inhibitor. SGTC_1067 clotrimazole 1.36 µM -0.729057493612559 0.242400555814311 no 2562 0.232983247162552 3745 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_3338 9144300 39.5675 µM -0.729229229918546 0.242347396481353 no 2563 0.232930727026448 3736 4901274 SGTC_573 3702-0553 84.7 µM -0.729613050023388 0.242228611473894 no 2564 0.232813371521694 3692 1222756 SGTC_1196 1588-0294 184 µM -0.731958115363526 0.241503544364444 no 2565 0.232097066474225 3734 6144269 SGTC_1615 st002656 86.5 µM -0.732242727555101 0.241415625842404 no 2566 0.232010214651979 3736 1584458 SGTC_3157 9099274 49.47 µM -0.733699700818237 0.240965829943223 no 2567 0.231565890449895 3690 17217662 SGTC_860 0443-0016 25.1 µM -0.734266301232019 0.240791032578739 no 2568 0.231393225975766 3753 5337942 SGTC_1523 st012844 44.7 µM -0.734458672084336 0.240731701477742 no 2569 0.231334619665957 3829 4274103 SGTC_123 0083-0120 66.675 µM -0.735536320413301 0.240399479885279 no 2570 0.231006464272217 3703 16001701 SGTC_1678 st019265 80.2 µM -0.738682926935936 0.239430862639731 no 2571 0.230049777691012 3736 5367020 SGTC_2908 7930301 100 µM -0.741268066279026 0.238636678865254 no 2572 0.229265459994826 3747 2223178 SGTC_272 doxorubicin 8.13 µM -0.741368900588292 0.238605730674863 no 2573 0.229234897805955 3739 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_2004 4023728 41.89 µM -0.742491034670393 0.238261472185607 no 2574 0.228894940857813 3726 360084 YDR527W RBA50 SGTC_328 k915-0120 63.5 µM -0.742544468799417 0.238245085967416 no 2575 0.228878759742788 3744 6624543 SGTC_1661 st013063 9.66 µM -0.743810617974154 0.237856986785999 no 2576 0.228495527787325 3783 721395 SGTC_787 4152-0075 138 µM -0.744233494901449 0.237727444112167 no 2577 0.228367613777755 3769 9566539 SGTC_1329 1447-1697 50.6 µM -0.747781771609656 0.23664200340731 no 2578 0.227295899397271 3772 2840515 SGTC_884 0851-0618 334 µM -0.747891937227133 0.236608346730762 no 2579 0.227262670618428 3786 9642473 SGTC_1013 4112-3890 241 µM -0.748690482800062 0.236364461977549 no 2580 0.227021890624855 3712 705171 SGTC_3312 9133330 71.43 µM -0.751053346630107 0.235643628193753 no 2581 0.226310275599554 3801 17617324 SGTC_1011 4112-3381 17.4 µM -0.751240309426226 0.235586643668276 no 2582 0.226254022545531 3828 2877139 SGTC_78 0336-0123 156.75 µM -0.751992079144116 0.235357587989507 no 2583 0.226027911087317 3635 6765896 SGTC_1693 xanthone 101.9 µM -0.752778638428593 0.235118063978337 no 2584 0.225791472692067 3815 7020 An insecticide. SGTC_2290 7904846 200 µM -0.75338676869095 0.234932967721546 no 2585 0.225608765690164 3824 2962154 SGTC_196 k015-0023 18.111 µM -0.754127177622442 0.234707718623078 no 2586 0.225386429787513 3742 5211998 SGTC_3334 9142812 21.919 µM -0.756057539754348 0.23412102079607 no 2587 0.224807348962261 3818 45283678 SGTC_412 gemfibrozil 100 µM -0.75678930757906 0.233898825980809 no 2588 0.224588049863981 3730 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels. SGTC_1088 bifonazole 369 nM -0.757587533108039 0.233656585170996 no 2589 0.224348972911072 3695 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase. SGTC_1763 st044482 94.5 µM -0.757903122022008 0.233560850476222 no 2590 0.224254490571347 3792 88505 SGTC_732 3970-1727 52.7 µM -0.758549439613403 0.233364856309708 no 2591 0.224061063814456 3782 1275699 SGTC_1808 st050063 61.5 µM -0.758749032814235 0.233304348625876 no 2592 0.224001349698918 3745 4011993 SGTC_1846 st056244 14.8 µM -0.759462837078194 0.233088026527595 no 2593 0.22378786837945 3803 5393182 SGTC_1686 st019653 115.5 µM -0.760381650989773 0.232809739201663 no 2594 0.223513244031829 3749 97252 SGTC_1527 coumarin 137 µM -0.760710497407873 0.232710184161952 no 2595 0.223415001707198 3849 323 A hepatotoxic, DNA x-linker. SGTC_2566 crystal violet carbinol 226 nM -0.760773988605944 0.232690965547621 no 2596 0.223396036646611 3761 68050 Cationic dye that binds acidic phospholipids including cardiolipin. SGTC_2433 5607874 27.82 µM -0.762327705514805 0.232220934664558 no 2597 0.222932221109794 3774 2252428 SGTC_1032 k061-1018 98.7 µM -0.765217383773266 0.231348155137964 no 2598 0.222071054909489 3904 4005393 SGTC_2667 digitoxin 100 µM -0.765297356880943 0.231324026627984 no 2599 0.222047248794752 3738 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_803 4488-1585 147 µM -0.767077050144844 0.230787442605587 no 2600 0.221517853023648 3807 747204 SGTC_178 4092-0806 87.505 µM -0.768338272204799 0.230407600824808 no 2601 0.221143121312934 3746 2169044 SGTC_1801 st050089 28.441 µM -0.769688968930284 0.230001199858547 no 2602 0.220742207572641 3805 5008493 YIL048W | YNL267W NEO1 | PIK1 SGTC_2890 9046729 58.44 µM -0.7705252158183 0.22974978903615 no 2603 0.220494201587835 3730 903329 SGTC_1312 1218-2183 165 µM -0.771272147767895 0.229525360201606 no 2604 0.220272818827358 3788 6744073 SGTC_1308 1187-1617 41.4 µM -0.771486559906048 0.229460959004917 no 2605 0.22020929287923 3781 2882570 SGTC_1749 st037932 54.2 µM -0.773758533777353 0.228779167545773 no 2606 0.219536799101066 3821 594497 SGTC_2015 5119600 184 µM -0.77515823010666 0.228359702629975 no 2607 0.219123083358483 3806 2828786 SGTC_538 2922-0838 53.3 µM -0.775273224329586 0.228325260062701 no 2608 0.219089113838672 3787 777039 SGTC_1834 st055981 52.8 µM -0.776234154009765 0.228037560764074 no 2609 0.218805371720498 3849 471719 YDL150W RPC53 SGTC_3082 9117008 49.47 µM -0.779019428156307 0.227204811531742 no 2610 0.217984135155667 3874 41448529 SGTC_3318 9139014 38.6185 µM -0.779253252435279 0.227134980149207 no 2611 0.217915273146421 3774 16643984 SGTC_1454 4239-0054 42.6 µM -0.779300313806788 0.227120926781324 no 2612 0.217901414936361 3930 1340767 SGTC_1178 0988-0033 191 µM -0.782599055300553 0.226137085670759 no 2613 0.216931298216315 3851 5392207 SGTC_1806 st050005 60.3 µM -0.783583224589863 0.225844026865021 no 2614 0.216642351150318 3809 5194765 SGTC_1725 st036284 20.55 µM -0.786802640937229 0.224886874316751 no 2615 0.215698703642305 3893 707914 SGTC_2849 9019321 12.99 µM -0.79063833501138 0.223749506443368 no 2616 0.214577534930844 3817 16489627 SGTC_1663 st014140 55.4 µM -0.793339979207225 0.222950376025763 no 2617 0.213789884977893 3881 4207120 SGTC_2660 2',4'-dihydroxychalcone 17.14 µM -0.793636534064411 0.222862755979348 no 2618 0.213703528667959 3843 5357218 A potent inhibitor of glutathione S-transferases. SGTC_1204 4049-0315 18.3 µM -0.794073792988604 0.222733599330299 no 2619 0.213576236627592 3930 588402 SGTC_45 0kpi-0036 14.9 µM -0.794930165291766 0.222480769453464 no 2620 0.213327062994953 3818 2795021 SGTC_2235 salicylic acid 500 µM -0.79512633648694 0.222422876173537 no 2621 0.213270008079724 3826 338 A COX inhibitor and kinase inhibitor. SGTC_154 3389-1638 511.116 µM -0.79592055485561 0.22218857736942 no 2622 0.213039106599321 3788 5238686 SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM -0.796441667037455 0.222034922955541 no 2623 0.212887683996679 3815 803109 SGTC_3339 9145883 14.936 µM -0.797697781261069 0.221664796315269 no 2624 0.212522945862497 3735 2030670 SGTC_2912 7964298 10.93 µM -0.797936452125155 0.221594509433904 no 2625 0.212453684247597 3882 2975850 SGTC_1627 st003713 25.6 µM -0.798505295166099 0.221427040547885 no 2626 0.212288660774381 3900 16195070 YER133W GLC7 SGTC_813 k007-0158 173 µM -0.798720299886179 0.221363761442517 no 2627 0.212226306623258 3845 6523916 SGTC_88 0180-0332 8.668 µM -0.798920345716271 0.221304894250176 no 2628 0.212168300359364 3895 3101745 SGTC_920 mycophenolic acid 780.421 nM -0.799273211588767 0.221201078756567 no 2629 0.212066004248607 3863 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_3321 9137793 26.8275 µM -0.800848225752184 0.220738038923177 no 2630 0.211609758130464 3794 4904192 SGTC_1246 0422-0085 105 µM -0.801819878789341 0.220452658857034 no 2631 0.211328578954185 3852 264295 SGTC_1206 3978-0017 132 µM -0.803418803568278 0.219983506063747 no 2632 0.210866355151753 3924 3873677 SGTC_2543 pimpinellin 60.67 µM -0.803870733139448 0.219851005854091 no 2633 0.210735817022975 3717 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo. SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM -0.804564491097066 0.219647693682704 no 2634 0.210535519953612 3748 1241132 A phosphatase inhibitor. SGTC_2421 5690543 90.72 µM -0.80478524072619 0.219583023616808 no 2635 0.210471810063866 3884 3397993 SGTC_97 0535-0701 19.132 µM -0.805635776868909 0.219333955681572 no 2636 0.210226445190616 3756 2832013 YGL099W LSG1 SGTC_1579 chlormadinone acetate 49.4 µM -0.805652715264144 0.219328997152409 no 2637 0.210221560465106 3872 45114258 A steroidal progestin. SGTC_1600 coumarin 106 71.1 µM -0.806257154946726 0.219152096244853 no 2638 0.210047294674289 3935 100336 A hepatotoxic, DNA x-linker. SGTC_262 fenpropimorph 62.5 µM -0.80815036669811 0.21859854253594 no 2639 0.209502013016644 3792 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_665 3914-0008 307 µM -0.80922662335663 0.21828421646519 no 2640 0.209192401867783 3806 1069549 SGTC_213 1246-0773 967 nM -0.809588401333356 0.218178615927514 no 2641 0.209088388242375 3835 6251622 SGTC_1383 3049-0032 20.7 µM -0.811266918787017 0.217689053402186 no 2642 0.208606201657283 3918 712864 SGTC_742 0kpi-0133 140 µM -0.811591913632593 0.217594337512052 no 2643 0.208512916413271 3910 2728852 SGTC_2412 st077135 33.4 µM -0.811927563743788 0.217496541240963 no 2644 0.208416598548795 3946 13258915 SGTC_1919 st067113 52.3 µM -0.812453658500795 0.217343307366682 no 2645 0.208265683662437 3897 1268243 SGTC_532 1548-0774 215 µM -0.812576668100613 0.21730748776301 no 2646 0.208230406583861 3993 5932993 SGTC_722 3534-0461 190 µM -0.812971370795714 0.217192575901101 no 2647 0.208117236316877 3893 658262 SGTC_1629 st005085 44.9 µM -0.813136020626263 0.2171446509113 no 2648 0.208070038186081 3835 24207091 SGTC_2407 paclitaxel 400 µM -0.813638943477733 0.216998301882981 no 2649 0.20792591063963 4029 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_623 k072-0108 16.9 µM -0.815870055809751 0.216349742717069 no 2650 0.207287230034837 3854 5382803 SGTC_2847 9005661 71.43 µM -0.816211981071313 0.21625044815014 no 2651 0.20718945276131 3828 2991449 SGTC_2061 5245884 80.95 µM -0.81674812476916 0.216094805982961 no 2652 0.207036191532621 3837 573863 SGTC_90 0870-0863 4.608 µM -0.817360227973217 0.215917192165556 no 2653 0.206861298665179 3844 1738164 SGTC_427 1354-0053 47.3 µM -0.817880184620272 0.215766382957173 no 2654 0.206712803039776 3985 6813657 SGTC_2171 5739187 198.077 µM -0.818140890992456 0.215690790175715 no 2655 0.206638371065662 3790 2262761 SGTC_2248 tofa 1.1 µM -0.818596894155721 0.215558607284662 no 2656 0.206508219795808 3793 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_1731 st035964 63 µM -0.818711622545493 0.215525358048882 no 2657 0.206475481956443 3851 6739575 SGTC_2385 9074692 200 µM -0.820490039358739 0.215010338691751 no 2658 0.205968402617084 3892 17046906 SGTC_494 Boc-Gly-Val-Val-CHO 140 µM -0.821116562541971 0.214829071524766 no 2659 0.205789938383325 3891 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA. SGTC_3344 9148862 3.898 µM -0.822424807339292 0.214450853418693 no 2660 0.205417582682382 3888 4905352 SGTC_2928 9011484 9.79 µM -0.823311110988503 0.214194840115273 no 2661 0.205165548372592 3895 2994751 SGTC_2423 st077119 87.2 µM -0.825456574240204 0.213575848906935 no 2662 0.204556213602313 3804 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae). SGTC_1623 st003709 20.3 µM -0.826970830775542 0.21313959633157 no 2663 0.204126797339912 3846 16192618 SGTC_1174 0739-0097 51.1 µM -0.827045721454452 0.213118034058044 no 2664 0.204105573617071 3876 728447 SGTC_2844 9010103 25.97 µM -0.82773407003037 0.212919906643432 no 2665 0.203910559919227 3944 2480525 SGTC_2989 9073649 71.4286 µM -0.827889139504927 0.212875287826401 no 2666 0.203866643042608 3792 21367202 SGTC_1098 clofazimine 15.1 µM -0.829475807523686 0.212419062588343 no 2667 0.203417610382978 3948 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2 SGTC_1478 0453-0656 35.7 µM -0.830644144322227 0.212083488424981 no 2668 0.203087344464337 3891 5258496 SGTC_3315 9136395 68.55 µM -0.832788196244753 0.211468472685741 no 2669 0.202482096487398 3868 16876844 SGTC_938 3126-1755 342 µM -0.834117773776648 0.21108761201185 no 2670 0.202107310174697 3914 1777771 SGTC_1509 1326-1131 80 µM -0.835404452394814 0.2107194229055 no 2671 0.201745011894713 3779 768313 SGTC_2510 benzyl isothiocyanate 8.31 µM -0.838096235118326 0.209950376290753 no 2672 0.200988328610585 3856 2346 DNA damaging agent; causes G2/M arrest. SGTC_159 3970-0959 50 µM -0.83864467752229 0.209793887935234 no 2673 0.20083436577902 3960 6615653 SGTC_754 3474-0146 171 µM -0.840060813915996 0.209390135678824 no 2674 0.200437144890948 3868 24762078 SGTC_1977 st070720 65.3 µM -0.840278534959429 0.209328102177286 no 2675 0.200376116843582 3919 682188 SGTC_608 k048-0125 159 µM -0.841947004941366 0.208853077629293 no 2676 0.199908808925465 3923 6817652 YLR060W | YFL022C FRS1 | FRS2 SGTC_1066 ketoconazole 628 nM -0.844841499882697 0.208030503876073 no 2677 0.199099670224851 3962 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W SGTC_1607 st000305 50.6 µM -0.846068662805473 0.207682339936433 no 2678 0.198757220616181 3906 5457690 SGTC_2873 9040596 71.43 µM -0.846506421542615 0.207558224778124 no 2679 0.198635146533847 3868 6463863 SGTC_2975 9084847 53.72 µM -0.846950461800787 0.207432373449357 no 2680 0.198511366983035 3973 27211724 SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM -0.849120502681295 0.206817982629842 no 2681 0.197907121461817 3987 4213774 SGTC_1217 1183-1422 255 µM -0.849873191460559 0.206605130193325 no 2682 0.19769779587986 3933 2849664 SGTC_18 0111-0177 500 nM -0.850403662243851 0.206455196629423 no 2683 0.197550350371338 3945 721752 SGTC_2172 5754775 163.918 µM -0.852019887299121 0.205998780397021 no 2684 0.197101527106688 3880 2263357 SGTC_1175 0741-0056 27.6 µM -0.852930492503543 0.205741892489121 no 2685 0.196848925411484 4007 765927 SGTC_883 0850-0245 24.6 µM -0.854340914357932 0.205344378390621 no 2686 0.196458061825814 4004 6823229 YPR165W RHO1 SGTC_2268 7933382 153.85 µM -0.854636333232869 0.205261175187027 no 2687 0.196376253393242 3925 935025 YOR257W CDC31 SGTC_2298 7976326 193.81 µM -0.858496612331993 0.2041757894268 no 2688 0.195309150151388 3787 2235818 SGTC_1862 st057513 3.81 µM -0.858637487400605 0.204136244664163 no 2689 0.195270274573471 3886 5393163 SGTC_554 4483-2211 187 µM -0.860316174955994 0.203665374750815 no 2690 0.194807389512648 3958 747107 SGTC_411 enrofloxacin 100 µM -0.862437086214594 0.203071388519816 no 2691 0.194223519905277 4017 71188 A bacterial gyrase inhibitor. SGTC_741 4582-0002 126 µM -0.863985621647776 0.202638356914639 no 2692 0.193797894596673 3881 2912688 SGTC_1812 st052057 4.327 µM -0.864035326281095 0.202624466685642 no 2693 0.193784242370858 3937 3645418 SGTC_2008 4012253 172 µM -0.864183007377467 0.202583199760761 no 2694 0.193743682696315 3930 603940 SGTC_126 0417-1624 672.48 µM -0.865030624377977 0.202346445046938 no 2695 0.193510990189292 3978 41912 YDL195W SEC31 SGTC_2196 6573537 42.6665 µM -0.865358918221062 0.202254791131949 no 2696 0.19342091096618 3936 2903087 SGTC_3068 9116768 49.47 µM -0.867145918201912 0.201756327554241 no 2697 0.192931032019987 3883 41904888 SGTC_3033 9090887 49.47 µM -0.868194060293952 0.201464302698399 no 2698 0.192644052661921 3955 19325384 SGTC_2805 7950783 58.44 µM -0.869939119876295 0.200978670622388 no 2699 0.192166837698993 3959 1178958 YDL195W SEC31 SGTC_3260 9137109 49.47 µM -0.871468267600585 0.200553702444389 no 2700 0.191749262436154 3839 17478346 SGTC_906 1165-0455 526 µM -0.875294645155729 0.199492674091757 no 2701 0.190706803498584 3907 3252859 SGTC_3114 9122766 49.47 µM -0.877696939658203 0.198828264171301 no 2702 0.190054102865015 3943 17176985 SGTC_2585 alliin 100 µM -0.879355595290917 0.198370304150542 no 2703 0.189604250283373 4000 87310 A garlic compound which reacts with lipids. SGTC_959 1222-0044 107 µM -0.879434344488766 0.198348577089511 no 2704 0.189582908606923 3913 6083612 SGTC_2259 7964009 200 µM -0.879954016046672 0.198205234679355 no 2705 0.189442110424958 3991 313134 SGTC_31 0508-1974 57.237 µM -0.880045056717163 0.198180129123981 no 2706 0.189417450777295 3894 6810525 SGTC_3003 9075612 71.4286 µM -0.880280844252826 0.198115116811852 no 2707 0.189353593587315 3971 6501993 SGTC_2854 9024559 71.43 µM -0.880387411240516 0.198085737947973 no 2708 0.189324736917425 3999 3163529 SGTC_2319 6033012 152.6 µM -0.881855904808247 0.197681165018516 no 2709 0.188927367595946 3901 847246 SGTC_1163 k060-0048 49.9 µM -0.882932290355777 0.197384936059624 no 2710 0.188636427969475 3941 6809982 SGTC_1674 st016616 23.6 µM -0.883599233167571 0.197201523432566 no 2711 0.188456296573437 3919 625830 SGTC_3345 9148410 3.559 µM -0.884224159008849 0.197029759291046 no 2712 0.188287609643944 3917 4903596 SGTC_1405 3909-7894 12 µM -0.884309666721422 0.197006264092849 no 2713 0.188264535698975 3957 7104060 SGTC_2976 9009005 19.48 µM -0.885808861226367 0.196594601711732 no 2714 0.187860267004476 3967 2993148 SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM -0.886324565293355 0.196453115579633 no 2715 0.187721327663558 3962 1377 SGTC_1256 0570-0116 285 µM -0.891202745279035 0.195117816043344 no 2716 0.186410205954157 3966 410638 SGTC_1159 4092-0538 61.2 µM -0.891729715834122 0.194973899795038 no 2717 0.186268910923747 3992 717301 SGTC_3126 9127922 49.47 µM -0.891976873208513 0.194906423079456 no 2718 0.186202664227621 4010 45595682 SGTC_1079 idarubicin 2.36 µM -0.897954067968141 0.193278909771278 no 2719 0.184605018815563 3972 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_3159 9100096 49.47 µM -0.899085632408803 0.19297173563434 no 2720 0.18430352517873 3923 25236875 SGTC_2441 5730946 39.09 µM -0.899212231989057 0.192937387504298 no 2721 0.184269813097732 4040 1774275 SGTC_1199 1638-0010 4.46 µM -0.899596695658877 0.192833100347771 no 2722 0.18416745815857 3953 3111136 SGTC_2835 9006588 71.43 µM -0.900980188051155 0.192458108048337 no 2723 0.183799426812996 4056 2345538 SGTC_3095 9117207 49.47 µM -0.901784310176271 0.192240357690993 no 2724 0.1835857279938 3948 17015229 SGTC_1894 3',6'-dihydroxyflavone 78.7 µM -0.906163283080031 0.191057210860628 no 2725 0.182424716957818 3975 688662 SGTC_2363 9053361 176 µM -0.908129315653909 0.190527467734654 no 2726 0.181904951793119 4056 6469797 YMR079W SEC14 SGTC_756 0508-1999 28.3 µM -0.908226687825674 0.190501254477724 no 2727 0.181879233352091 3979 6753853 SGTC_1266 0828-0227 32.9 µM -0.90849445294311 0.190429181688479 no 2728 0.181808521572547 4005 3913820 SGTC_3024 9090631 49.47 µM -0.909123861264678 0.190259833440326 no 2729 0.181642374291888 3943 25236383 SGTC_116 0155-0182 31.788 µM -0.909334816113951 0.190203094754661 no 2730 0.181586709012771 3901 771486 SGTC_942 3253-1115 227 µM -0.909554938954028 0.190143901319194 no 2731 0.181528635932138 4043 46497897 SGTC_984 1492-0255 2.91 µM -0.911281436321482 0.189680019997331 no 2732 0.181073552486387 3953 1585198 SGTC_1333 1482-0047 286 µM -0.912051560652238 0.189473325009941 no 2733 0.180870787920766 3970 3811116 SGTC_1185 1319-0113 81.3 µM -0.912812884635308 0.189269128257503 no 2734 0.180670480321195 4055 4672763 SGTC_1037 k284-1091 78.7 µM -0.91282747759216 0.189265215565109 no 2735 0.180666642210918 3952 3334711 SGTC_98 0074-0023 107.663 µM -0.913186755863515 0.189168900871603 no 2736 0.180572164146438 3991 3563821 SGTC_1086 cerivastatin 2.18 µM -0.914737863526468 0.188753429157532 no 2737 0.180164630916804 3953 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7 SGTC_1835 st008666 49.2 µM -0.914876019518525 0.188716450701769 no 2738 0.1801283602615 3935 690455 SGTC_1234 0326-0494 15.5 µM -0.915305326644319 0.188601572027301 no 2739 0.18001568176844 4070 1547813 SGTC_1820 st053765 18.6 µM -0.917537813590467 0.188004874192212 no 2740 0.179430443739245 4051 3690829 SGTC_402 epigallocatechin gallate 10 µM -0.918240575565464 0.187817281806677 no 2741 0.1792464651429 3933 65064 An antioxidant. SGTC_2899 9053889 58.44 µM -0.919314031815928 0.187530961055457 no 2742 0.178965670258285 3954 6470052 SGTC_3083 9117465 49.47 µM -0.921876211707642 0.1868486471452 no 2743 0.178296574336087 3995 16420915 SGTC_3215 9129942 49.47 µM -0.922181897998125 0.186767344949008 no 2744 0.178216851819809 3969 17682944 SGTC_16 erodoxin 22.806 µM -0.923437210450139 0.186433704016149 no 2745 0.177889703872546 4010 3967339 Erodoxin inhibits Ero1. YML130C ERO1 SGTC_316 k060-0003 58.6 µM -0.923973131764794 0.186291377666259 no 2746 0.177750152444555 4020 6152314 SGTC_2182 6325192 200 µM -0.925547635797025 0.185873621143612 no 2747 0.177340558549228 3915 736248 SGTC_2948 9070189 9.45 µM -0.926046985291728 0.185741252284146 no 2748 0.177210781577376 3947 6473636 YDL196W YDL196W SGTC_25 0118-0223 35.662 µM -0.927621214648732 0.185324334378151 no 2749 0.176802044599957 3991 5333628 SGTC_3205 9113483 49.47 µM -0.929396390141996 0.184854895652737 no 2750 0.176341848953661 4074 17018033 SGTC_2395 5646831 180.19 µM -0.930011207196376 0.184692481968718 no 2751 0.176182640935253 4043 6808628 SGTC_2336 9001819 198.65 µM -0.930829518112898 0.184476449822288 no 2752 0.175970878979123 4061 2989602 SGTC_1279 0874-0590 65.2 µM -0.932202249445779 0.184114405150496 no 2753 0.175616006595082 4071 3523074 SGTC_901 1112-0062 60.1 µM -0.93309468208386 0.183879272043356 no 2754 0.175385542307148 4006 1908457 SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM -0.936388193653252 0.183013135953756 no 2755 0.174536677231005 4020 7104 SGTC_3089 9117425 49.47 µM -0.938310882273965 0.182508681162085 no 2756 0.174042334443337 4008 9401657 SGTC_2143 5623677 140.463 µM -0.938373645767996 0.182492228589185 no 2757 0.174026212327824 3938 5375313 SGTC_3180 9109287 49.47 µM -0.940515549840463 0.181931313735894 no 2758 0.173476588643305 4063 18891271 SGTC_1675 st018485 24.5 µM -0.940838104504238 0.181846937677196 no 2759 0.173393915265142 4074 3323024 SGTC_68 0986-0284 82.829 µM -0.941759695042509 0.181605996610533 no 2760 0.173157842360178 4104 423278 YIL048W NEO1 SGTC_1537 2',6'-dihydroxyflavanone 78 µM -0.941901632400529 0.181568906202226 no 2761 0.173121502152177 4015 5106787 A p450 inhibitor. SGTC_2504 purpurogallin 52.29 µM -0.942573514946869 0.181393397333589 no 2762 0.172949546056751 3930 5281571 An antioxidant. SGTC_830 4076-0286 57.8 µM -0.943315939382393 0.181199585116897 no 2763 0.172759662660435 4084 6866659 SGTC_2173 5763948 167 µM -0.944127632488834 0.18098783857676 no 2764 0.172552215142896 4008 2867177 SGTC_478 N-arachidonylglycine 10 µM -0.945499655027143 0.180630271504057 no 2765 0.17220192342636 3972 5283389 SGTC_1080 nisoldipine 24.4 µM -0.946352203925016 0.1804083093899 no 2766 0.17198448752574 4015 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class. SGTC_2520 obtusaquinone 4.71 µM -0.948102346833477 0.179953194086233 no 2767 0.171538676825217 4075 5967872 SGTC_550 4123-0385 25.7 µM -0.953454003206056 0.178566002725568 no 2768 0.170180045385859 4067 5731123 SGTC_1359 1582-0056 520 nM -0.953987509481413 0.178428083825571 no 2769 0.170044982477401 4101 3661189 SGTC_2581 avocatin a 64 µM -0.95537729977595 0.178069118641461 no 2770 0.169693464673804 4016 6710728 A skin care supplement. SGTC_649 1123-0311 367 µM -0.955720529107352 0.177980537018235 no 2771 0.169606723954515 3939 693629 YIL048W NEO1 SGTC_2369 9071472 200 µM -0.955893539270319 0.177935896587618 no 2772 0.169563011709829 4104 17296037 SGTC_1729 st035615 45.989 µM -0.956097399348687 0.177883305262287 no 2773 0.169511514292053 4072 17385451 SGTC_1408 3909-7976 48.8 µM -0.956515060036775 0.177775588799016 no 2774 0.169406039707879 4075 24152374 SGTC_2194 5927483 104.545 µM -0.958059564777143 0.177377612010366 no 2775 0.16901636179216 4051 760979 SGTC_620 0109-0052 432 µM -0.962617836810643 0.176206352478637 no 2776 0.167869671482894 4036 493037 SGTC_1737 st035557 69.7 µM -0.96371444394531 0.175925308599092 no 2777 0.167594555373288 3925 5716916 SGTC_2505 galangin 7.89 µM -0.964229600912829 0.175793379687284 no 2778 0.167465413436906 3938 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_629 3448-6466 76.7 µM -0.964252725160183 0.175787459162723 no 2779 0.167459618047378 4050 573744 SGTC_1557 sumaresinolic acid 42.3 µM -0.96427998566385 0.175780479790474 no 2780 0.167452786196924 4020 9982268 A natural terpine and antifungal of unknown mechanisn. SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM -0.965915403403493 0.175362093029919 no 2781 0.167043256988371 4063 6728940 SGTC_284 0988-0104 32.6 µM -0.966491703464053 0.175214809512508 no 2782 0.166899098216291 4032 4666532 SGTC_119 0121-0043 24.815 µM -0.966692671996573 0.17516346695814 no 2783 0.166848845752361 4062 1092378 SGTC_1570 verbenone 133 µM -0.968233867930327 0.174770046258698 no 2784 0.166463792036805 4076 29025 A natural terpanoid with antifungal properties. SGTC_3106 9121286 49.47 µM -0.969708000247461 0.17439427013254 no 2785 0.166096030782623 4071 15943471 SGTC_1851 st056236 18.9 µM -0.970349083612316 0.174231009639062 no 2786 0.165936259504217 4050 5393171 SGTC_2149 5554786 194.827 µM -0.97260675301859 0.173656837403773 no 2787 0.165374392538548 4076 745063 YPR165W RHO1 SGTC_2845 9003024 42.97 µM -0.972654666392241 0.173644665097474 no 2788 0.165362481675048 4136 2990173 SGTC_28 pentachloropyridine N-oxide 1.606 µM -0.972694258454658 0.17363460721494 no 2789 0.165352639838683 4047 140250 A respiratory chain inhibitor. SGTC_1906 st060206 94.7 µM -0.973053121267699 0.173543459383346 no 2790 0.165263450631427 4084 5133468 SGTC_21 0849-0113 22.993 µM -0.974018461673647 0.173298423012032 no 2791 0.165023686348188 4012 1560156 SGTC_2951 9072950 58.06 µM -0.97467862880575 0.173130976941859 no 2792 0.164859848541394 4038 16488155 SGTC_2481 5478948 45.16 µM -0.974683686076928 0.173129694603661 no 2793 0.164858593853525 4106 77792 SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM -0.975243571909968 0.17298776553158 no 2794 0.164719726759088 4116 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_1241 0364-0022 50.8 µM -0.976578584058957 0.172649643894193 no 2795 0.164388912880015 4090 4563895 SGTC_2166 5933061 31.504 µM -0.976948412611207 0.172556051134844 no 2796 0.164297346193001 4168 2877375 SGTC_1491 4138-0063 26.5 µM -0.977902568472111 0.172314731717752 no 2797 0.164061257345973 4022 23883227 SGTC_2376 9072922 81.32 µM -0.978110804378061 0.172262094568839 no 2798 0.164009762355653 4105 17087968 SGTC_834 0312-0008 75.7 µM -0.979825655093548 0.17182901075329 no 2799 0.163586092981236 4061 6385573 YIL048W NEO1 SGTC_2137 5261020 140 µM -0.981493445606254 0.171408479528946 no 2800 0.163174732518407 4023 763655 SGTC_303 1348-1668 34.2 µM -0.98200751174188 0.171278991160435 no 2801 0.163048073777422 4070 5380509 SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM -0.982590660325308 0.171132177313024 no 2802 0.162904471468827 4113 688788 SGTC_636 0kpi-0074 126 µM -0.984414405756843 0.170673549644638 no 2803 0.162455898913885 4065 616434 SGTC_198 3454-2873 16.191 µM -0.988561455693604 0.169633599035073 no 2804 0.161438876199331 4051 710957 SGTC_1424 4048-1941 275 µM -0.990633871488418 0.169115428342781 no 2805 0.160932196041752 4144 X1424 SGTC_889 0919-1524 82.7 µM -0.990968279197056 0.169031910983121 no 2806 0.160850534839017 4110 3905452 SGTC_1532 4',5'-dihydroxyflavone 78.7 µM -0.991674660636457 0.16885558135125 no 2807 0.160678127881868 4103 165521 SGTC_2732 terfenadine 20 µM -0.992215342065134 0.168720694267278 no 2808 0.160546244999661 4117 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.  SGTC_2953 9074162 66.49 µM -0.992343929090245 0.168688625075811 no 2809 0.160514890495113 4072 16451992 SGTC_1564 D-Arginine 115 µM -0.993129189189613 0.168492868746763 no 2810 0.160323500438246 4093 71070 D-isomer of arginine; arginine decarboxylase inhibitor. SGTC_1054 3429-0080 167 µM -0.993715715656614 0.168346749760331 no 2811 0.16018064471734 4139 1162877 SGTC_1028 k015-0029 4.8 µM -0.993778895509031 0.168331014880758 no 2812 0.160165261454765 4035 4588309 SGTC_1419 3993-2473 62.6 µM -0.995304918449335 0.167951247746288 no 2813 0.159793993182152 4148 704026 SGTC_291 SEC14.278 35.5 µM -0.995751751722769 0.167840152967629 no 2814 0.159685389135511 4133 1068044 SGTC_2884 9058502 51.95 µM -0.997964582660519 0.167290681124994 no 2815 0.159148266572574 4135 6471554 SGTC_3269 9137823 49.47 µM -0.999685539265435 0.166864149837016 no 2816 0.158731356186937 3991 17682936 SGTC_1711 st032263 62.8 µM -1.00143302393834 0.166431762164317 no 2817 0.15830875254117 4094 3958979 SGTC_2438 5259590 200 µM -1.00402035493927 0.165792897362928 no 2818 0.157684401245835 4108 1201127 SGTC_102 gallobenzophenone 83.616 µM -1.00406916274135 0.165780860976224 no 2819 0.157672638955184 4107 70837 SGTC_1446 4239-0190 62 µM -1.00712576689166 0.165028203982635 no 2820 0.156937170121768 4107 1340085 SGTC_147 4466-0538 29.23 µM -1.00754329802983 0.164925563298363 no 2821 0.156836880806584 4190 6742687 YHR072W ERG7 SGTC_2802 7925815 54.55 µM -1.00826080699276 0.164749276365206 no 2822 0.156664636538459 4065 1262923 SGTC_296 1222-0039 74.9 µM -1.00829433944132 0.164741040663964 no 2823 0.156656589829216 4095 5984176 SGTC_341 1486-1430 230 µM -1.00930696297476 0.164492461983801 no 2824 0.156413720905195 4070 2054753 YPL210C SRP72 SGTC_2940 9060638 45.86 µM -1.01022029951797 0.164268464892556 no 2825 0.156194877900949 4085 4027022 SGTC_664 1222-0054 14.9 µM -1.01243609584025 0.163725860086327 no 2826 0.155664793499937 4082 6813991 SGTC_479 n-linoleoylglycine 10 µM -1.01377930992821 0.163397500522592 no 2827 0.155344035015818 4137 6433346 An anti-infammatory. SGTC_236 1509-0011 5.31 µM -1.01381918492893 0.163387759298014 no 2828 0.155334519567763 4156 3107280 SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM -1.01421924693451 0.163290047417874 no 2829 0.155239073292081 4054 5711223 A potent inhibitor of glutathione S-transferases. SGTC_456 gingerol 170 µM -1.01490250056513 0.163123256102518 no 2830 0.155076153057501 4156 442793 A herb. SGTC_2396 5342950 42.78 µM -1.01516654671954 0.163058828591667 no 2831 0.155013222123459 4096 1886677 SGTC_2303 7774051 200 µM -1.01678091070924 0.16266528201285 no 2832 0.154628832568179 4155 2953184 SGTC_96 0929-0093 37.281 µM -1.02086008647546 0.161673623820575 no 2833 0.15366036585009 4105 6991579 SGTC_2518 prenyletin 46.28 µM -1.02558038436005 0.160531035671383 no 2834 0.152544708710605 4074 3873459 A coumarin with calcium channel inhibitory activity. SGTC_2375 9072683 200 µM -1.02725293790831 0.160127448699604 no 2835 0.152150688304422 4184 16798029 SGTC_2519 cryptotanshinone 88.04 µM -1.02732155230748 0.160110906230478 no 2836 0.152134538558164 4106 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE) SGTC_1003 4049-0218 100 µM -1.0329977092122 0.158746292722713 no 2837 0.150802485347828 4157 295161 SGTC_2215 7188065 200 µM -1.03614248392916 0.157993544623901 no 2838 0.150067837410327 4148 940217 SGTC_1750 st081859 2.357 µM -1.03630176455391 0.15795548091715 no 2839 0.150030691603121 4090 5291695 SGTC_2508 celastrol 40.54 µM -1.03631788398191 0.157951629150885 no 2840 0.150026932735704 4071 122724 Celastrol is a natural product and antioxidant. SGTC_643 k048-0106 28.4 µM -1.04007470854424 0.157055611258823 no 2841 0.149152596434123 4133 6763920 SGTC_1621 st003705 32.4 µM -1.04147783572117 0.156721818911704 no 2842 0.148826917324033 4133 24207032 SGTC_1097 itavastatin 7.23 µM -1.04163084728492 0.156685446981971 no 2843 0.148791430650154 4143 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49 SGTC_1237 0330-0133 46.1 µM -1.04210438315935 0.156572919366242 no 2844 0.148681643325961 4081 X1237 YHR072W ERG7 SGTC_1020 4335-0961 93.3 µM -1.04259735908311 0.156455828698621 no 2845 0.148567406451927 4067 669075 SGTC_821 1114-0266 29.2 µM -1.04350104238277 0.15624133739588 no 2846 0.148358149146961 4159 3123235 SGTC_3194 9111903 49.47 µM -1.04428544094086 0.15605531572345 no 2847 0.148176673371696 4180 17087251 SGTC_1342 1486-1464 234 µM -1.04457507280969 0.15598666586384 no 2848 0.148109702693472 4169 3253938 SGTC_375 3970-0961 9.27 µM -1.04642302853389 0.155549123731328 no 2849 0.147682882581636 4084 2898222 SGTC_2983 9022671 12.99 µM -1.05212204761405 0.15420486503336 no 2850 0.146371778958841 4152 6405161 SGTC_197 4544-0043 41.561 µM -1.05267783175319 0.154074181628482 no 2851 0.146244336032025 4129 896523 SGTC_823 0417-1665 178 µM -1.05287657430905 0.154027468408465 no 2852 0.146198781876687 4138 3429856 SGTC_2350 9023895 38.85 µM -1.05567922085379 0.153369721368777 no 2853 0.145557396809804 4175 2997209 SGTC_1096 rimcazole 32.2 µM -1.05650830448414 0.153175502693363 no 2854 0.145368024402878 4069 18528119 A dopamine reuptake inhibitor. SGTC_1672 st016598 6.51 µM -1.05732935885319 0.152983325630415 no 2855 0.145180649377485 4153 4665860 YNL267W PIK1 SGTC_1129 3453-1384 223 µM -1.05924691169706 0.152535123542148 no 2856 0.144743672759401 4252 1084452 SGTC_1688 st021091 57.6 µM -1.05949808618283 0.15247647950184 no 2857 0.144686500186912 4178 3656366 SGTC_2730 imipramine 71.33 µM -1.05982364853501 0.152400489703177 no 2858 0.144612418016221 4122 3696 A tricyclic antidepressant. SGTC_1396 3511-0007 98.6 µM -1.06205403824951 0.151880568500977 no 2859 0.144105576944134 4164 X1396 SGTC_2269 7935389 174.42 µM -1.06235787490305 0.151809833119937 no 2860 0.144036624920486 4125 97605 SGTC_3246 9135460 32.98 µM -1.06417872932795 0.151386383707927 no 2861 0.143623870464814 4125 41446951 SGTC_882 0843-0131 351 µM -1.06820324240319 0.150453250787099 no 2862 0.14271442125042 4168 5425421 SGTC_1305 1181-0477 144 µM -1.06902326702502 0.150263588905293 no 2863 0.142529592690346 4225 6252086 SGTC_2337 9009472 200 µM -1.07154169648408 0.149682102808357 no 2864 0.141962966411871 4144 5742383 SGTC_638 3970-0837 4.09 µM -1.0724479954786 0.14947321314053 no 2865 0.14175943013278 4134 4118451 YLR208W SEC13 SGTC_2796 7949634 45.45 µM -1.07255690402836 0.149448124293914 no 2866 0.141734984801415 4136 2971588 SGTC_1513 0337-0559 19 µM -1.0735175154159 0.149226953658377 no 2867 0.141519492111024 4135 775073 SGTC_694 1315-0438 43.2 µM -1.07374373653902 0.149174900445067 no 2868 0.141468776536745 4157 6793154 SGTC_2602 kawain 100 µM -1.07424150040579 0.149060408266174 no 2869 0.141357228290666 4160 5369129 SGTC_878 0828-0289 13.7 µM -1.07601540431287 0.148652864673146 no 2870 0.140960183583551 4108 745350 YLR208W SEC13 SGTC_93 0109-0045 59.227 µM -1.07844417604503 0.148096078385244 no 2871 0.140417790793243 4278 88733 SGTC_1502 4534-4282 27.7 µM -1.07957298715785 0.147837778570676 no 2872 0.140166187915827 4117 3278949 SGTC_233 rapamycin 362 pM -1.08082726804403 0.147551122169349 no 2873 0.139886978244929 4156 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C SGTC_275 trichlorophene 5.69 µM -1.0810513876189 0.147499940574052 no 2874 0.139837127857027 4225 62616 SGTC_2276 7947513 42.08 µM -1.08263649726079 0.147138292846845 no 2875 0.139484900388129 4124 2105100 SGTC_2555 cholic acid 100 µM -1.08277430390327 0.147106879941859 no 2876 0.139454306889116 4133 6708657 Influences liver metabolism. SGTC_2041 5107442 45.335 µM -1.08296387061494 0.147063675721288 no 2877 0.139412229953622 4218 793005 SGTC_1867 st057372 64 µM -1.0852946895694 0.146533153351176 no 2878 0.13889557857765 4131 688837 SGTC_2200 6600604 21.907 µM -1.08627577777308 0.1463102305187 no 2879 0.138678500074308 4191 2904777 SGTC_3244 9134489 49.47 µM -1.08632812353834 0.146298342918125 no 2880 0.138666924392011 4186 16584271 SGTC_725 1497-0963 19 µM -1.0897276656282 0.145527703574181 no 2881 0.137916562788998 4297 3549977 SGTC_2777 climbazole 1.536 µM -1.09011383679207 0.145440335738394 no 2882 0.137831500946828 4034 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2 SGTC_1981 st071826 47 µM -1.09128335001228 0.145175958878303 no 2883 0.137574110892125 4212 11838600 SGTC_2804 7954240 19.48 µM -1.09347139046453 0.144682205612234 no 2884 0.13709344183737 4220 828705 SGTC_2903 5923464 63.88 µM -1.09362913554849 0.144646652616967 no 2885 0.137058832769822 4186 2876576 SGTC_1053 3366-3204 134 µM -1.09472647577105 0.144399494105694 no 2886 0.136818242949582 4210 3632071 YPR165W RHO1 SGTC_3048 9093155 49.47 µM -1.09681504987185 0.143929862628869 no 2887 0.136361124939801 4167 25236002 SGTC_1841 st054148 70 µM -1.09862305584071 0.143524151831668 no 2888 0.135966258422259 4226 675442 SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM -1.10113525070234 0.142961705974373 no 2889 0.135418898519851 4212 115019 SGTC_1338 1486-1223 76 µM -1.10114548831644 0.142959416964902 no 2890 0.135416671030713 4206 3444526 SGTC_972 1319-0219 195 µM -1.10232614157686 0.142695602970878 no 2891 0.135159954174424 4171 23903702 SGTC_3187 9109394 49.47 µM -1.1060821760492 0.141858516761896 no 2892 0.134345476349944 4203 17098090 SGTC_581 0958-0271 211 µM -1.10614093421638 0.141845448131429 no 2893 0.13433276175884 4194 4591145 SGTC_3319 9138450 16.7555 µM -1.10699562039907 0.141655446259887 no 2894 0.134147910931477 4135 2029690 SGTC_1626 st003712 1.76 µM -1.10745542458121 0.141553300385694 no 2895 0.134048537181127 4237 24207035 SGTC_792 4534-1957 155 µM -1.10872523855279 0.14127146944116 no 2896 0.13377436533641 4151 1717904 SGTC_2727 riluzole 51.77 µM -1.10883783201199 0.141246498073576 no 2897 0.133750073342055 4227 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.  SGTC_2469 5655019 90.81 µM -1.10976410768704 0.141041179015854 no 2898 0.133550344820994 4255 2788239 SGTC_1589 2',5'-dimethoxyflavone 47.2 µM -1.11114153041208 0.14073623278225 no 2899 0.133253717008894 4182 688667 SGTC_1194 1488-0194 225 µM -1.1118036243894 0.140589811793409 no 2900 0.133111296596879 4147 1391452 SGTC_2671 danthron 100 µM -1.11681565871034 0.139484763097553 no 2901 0.132036576109637 4198 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin. SGTC_1306 1185-0270 9.02 µM -1.11742565946611 0.139350675072957 no 2902 0.13190618448968 4246 1548076 SGTC_3181 9108277 49.47 µM -1.12143528563465 0.138471477446888 no 2903 0.13105131173231 4168 17097298 SGTC_496 calpeptin 138 µM -1.12280320568119 0.138172397924781 no 2904 0.130760541801927 4220 73364 A calpain inhibitor. SGTC_1838 st055369 84.5 µM -1.12320126104842 0.138085450624619 no 2905 0.130676013571227 4198 676036 SGTC_2318 6029776 164 µM -1.12325611710369 0.138073471333224 no 2906 0.130664367688538 4273 818325 SGTC_352 k048-0007 5.11 µM -1.12361306751883 0.137995538943699 no 2907 0.130588605017444 4185 6811911 SGTC_1242 0402-0103 60.1 µM -1.12377516542249 0.137960158286102 no 2908 0.130554209793028 4139 432868 SGTC_708 3448-5400 146 µM -1.12430180493903 0.137845252856671 no 2909 0.130442506465343 4172 3462195 SGTC_577 r071-0003 38.6 µM -1.12840918298877 0.136951320600495 no 2910 0.129573575686416 4213 4568517 YMR134W ERG29 SGTC_1848 st056003 16.4 µM -1.13114995475884 0.136357025879829 no 2911 0.128995990786856 4233 146492 SGTC_136 0097-0015 404.482 µM -1.13314177857913 0.135926237742011 no 2912 0.128577359573932 4219 4861337 SGTC_1039 k821-0043 94 µM -1.133415694846 0.135867068581234 no 2913 0.128519863102216 4227 15992768 SGTC_911 3456-4043 236 µM -1.13744498934177 0.134998730906674 no 2914 0.127676154473723 4230 914281 SGTC_625 k213-0058 121 µM -1.13962729128864 0.134530023870981 no 2915 0.127220805185083 4293 3655420 SGTC_2415 st077333 57.7 µM -1.13984736326146 0.134482819678443 no 2916 0.127174948750815 4277 2766255 SGTC_575 k072-0246 11.9 µM -1.14002011711318 0.134445772922361 no 2917 0.127138960059462 4312 6796779 SGTC_2935 9038016 29.96 µM -1.14053200523329 0.134336040568934 no 2918 0.127032363332431 4214 6463195 SGTC_1741 st038134 10.228 µM -1.14053643054898 0.134335092191767 no 2919 0.127031442066061 4288 1272587 SGTC_1105 epirubicin 18.1 µM -1.14110237797891 0.134213843454621 no 2920 0.126913660919981 4268 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_2740 felodipine 17.08 µM -1.14175073387601 0.134075031912615 no 2921 0.126778822934483 4260 3333 L-type calcium channel blocker SGTC_1825 st052143 62.6 µM -1.14449563828133 0.133488446988685 no 2922 0.126209072869527 4282 674173 SGTC_1578 josamycin 24.2 µM -1.14492603851481 0.133396630962994 no 2923 0.126119898329893 4237 5282165 A P450 substrate. SGTC_2124 5246320 200 µM -1.14529102608249 0.133318803278465 no 2924 0.126044311052165 4255 579342 SGTC_2122 5258151 111.688 µM -1.14778145810117 0.132788592841649 no 2925 0.125529396820286 4246 2173356 SGTC_1388 3346-4487 254 µM -1.14909225997126 0.132510108537643 no 2926 0.125258969811557 4308 3345614 SGTC_2761 levamisole 97.89 µM -1.14958384952323 0.132405772500878 no 2927 0.125157656621329 4262 26879 An alkaline phosphatase inhibitor. SGTC_841 0251-0215 91.2 µM -1.15194105832875 0.131906260065724 no 2928 0.12467264739325 4281 3888614 SGTC_1996 st072960 66.8 µM -1.15200096061971 0.131893583223595 no 2929 0.124660339292854 4272 1719405 SGTC_2549 cedrol 20.94 µM -1.15531853856388 0.131192811545872 no 2930 0.123980003512844 4187 6708665 A sedative which affects the nervous system. SGTC_3014 9081533 49.47 µM -1.15565217097721 0.131122480981573 no 2931 0.123911729576118 4295 21367265 SGTC_1081 sertraline 6 µM -1.15610116356361 0.13102787331424 no 2932 0.123819890083227 4238 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1 SGTC_1019 4262-0212 3.4 µM -1.16199338681832 0.129790686834615 no 2933 0.122619075603677 4269 4677213 SGTC_3055 9094636 49.47 µM -1.16580952194497 0.128993744618933 no 2934 0.121845733260382 4290 25236176 SGTC_2066 5222451 176 µM -1.16842025848989 0.128450490478141 no 2935 0.121318643610456 4215 2281147 SGTC_1987 st072290 61.9 µM -1.16869701901722 0.128392994108582 no 2936 0.121262861711132 4267 54697379 SGTC_654 1124-0271 80.9 µM -1.17083321809963 0.127949804778012 no 2937 0.120832911368553 4228 5403748 SGTC_527 4476-4215 268 µM -1.17705059991855 0.126665960470719 no 2938 0.119587655330679 4263 4418754 SGTC_1944 st076371 56.9 µM -1.18150554599139 0.125751581215203 no 2939 0.11870097578503 4241 24208455 SGTC_218 alverine citrate 93.75 µM -1.18219886608832 0.125609692127945 no 2940 0.118563401235419 4313 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_2102 5377816 72.7585 µM -1.18247241534245 0.125553740571215 no 2941 0.118509152245229 4320 1379702 SGTC_418 lividomycin a 100 µM -1.18315953243956 0.125413274878835 no 2942 0.118372963822879 4286 72394 An antibiotic. SGTC_3039 9090270 49.47 µM -1.1846835314608 0.125102118979619 no 2943 0.118071298107141 4283 17173750 SGTC_793 0488-0545 106 µM -1.18935634131282 0.12415143073695 no 2944 0.117149736596607 4304 292548 SGTC_2451 5856223 45.7 µM -1.19265013553603 0.123484349068791 no 2945 0.116503211033885 4254 2179896 SGTC_3009 9080819 71.4286 µM -1.19277583799541 0.123458940779931 no 2946 0.11647858763873 4293 17027216 SGTC_2475 5812728 15.03 µM -1.19384304614019 0.123243373088951 no 2947 0.116269684836708 4216 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2 SGTC_1868 st057644 42.7 µM -1.19388371235033 0.123235164052863 no 2948 0.116261729809255 4306 688665 SGTC_3329 9141233 27.5565 µM -1.198198577822 0.122366325204502 no 2949 0.115419859465348 4252 4909101 YNL103W MET4 SGTC_3292 9120825 59.784 µM -1.2001569863992 0.121973402983119 no 2950 0.115039188523504 4281 24824900 SGTC_2147 5545932 89.7195 µM -1.20048065220967 0.121908550227662 no 2951 0.114976361180992 4324 797404 SGTC_1624 st003710 6.25 µM -1.20080784744873 0.121843014905209 no 2952 0.114912873542627 4325 24207033 SGTC_228 caffeine 993.056 µM -1.20181968244706 0.121640506809004 no 2953 0.114716698978491 4292 2519 Caffeine is a phosphodiesterase inhibitor. SGTC_185 k048-0037 25.491 µM -1.20193390073599 0.121617662090099 no 2954 0.1146945693141 4343 6827589 SGTC_1778 st046819 58.9 µM -1.20195469763036 0.121613502842533 no 2955 0.114690540266246 4319 671715 SGTC_2089 5281248 129.67 µM -1.2021956244698 0.121565326283079 no 2956 0.114643872092028 4278 2737878 SGTC_1970 st070122 35.8 µM -1.20319223671342 0.121366182788052 no 2957 0.114450969200207 4311 102928 SGTC_141 0443-0274 32.331 µM -1.20367986800198 0.121268827708633 no 2958 0.114356668193116 4261 1627241 SGTC_702 1488-0190 94 µM -1.20566244379812 0.120873574116897 no 2959 0.113973835741949 4311 949357 SGTC_2680 butyl paraben 22.24 µM -1.20923008770012 0.120164600950806 no 2960 0.113287230749141 4393 7184 An antifungal and steroid mimetic. SGTC_118 0083-0097 135.343 µM -1.20965666162186 0.120080027399074 no 2961 0.113205333082039 4273 5207356 SGTC_1197 1601-0112 267 µM -1.21067428476473 0.119878440462485 no 2962 0.113010130834975 4272 7350313 SGTC_2285 7945142 200 µM -1.21270140125424 0.119477588344081 no 2963 0.11262200195621 4335 2970608 SGTC_3199 9111318 49.47 µM -1.2133069721857 0.119358023384666 no 2964 0.112506239118368 4225 8548020 SGTC_2360 9040895 200 µM -1.21511192756082 0.119002150876357 no 2965 0.112161702498077 4325 4914414 SGTC_376 3970-0862 59.1 µM -1.21611079551982 0.118805532264083 no 2966 0.111971359329728 4331 3135186 SGTC_433 pimozide 108 µM -1.21928361864594 0.1181825116115 no 2967 0.111368281974874 4219 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic SGTC_2513 baicalein 25.65 µM -1.22445073784951 0.117172839299637 no 2968 0.110391119524663 4298 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2 SGTC_790 1575-0012 79.1 µM -1.22507544262376 0.117051185219293 no 2969 0.110273398416337 4358 378741 YLR208W SEC13 SGTC_2914 7968218 45.32 µM -1.22647247234104 0.116779453661588 no 2970 0.110010464103086 4270 2977111 SGTC_3170 9103054 49.47 µM -1.22654455767868 0.116765444727707 no 2971 0.109996909169811 4282 16432970 SGTC_3326 9140064 16.379 µM -1.22873621394521 0.11634009086154 no 2972 0.109585361880481 4242 1868434 SGTC_3049 9092223 49.47 µM -1.22880392958845 0.116326966226076 no 2973 0.109572663928203 4291 8623917 SGTC_39 0986-0283 58.349 µM -1.22990810009243 0.11611310427805 no 2974 0.109365760315836 4392 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2 SGTC_1514 1189-1591 158 µM -1.23050728750706 0.115997167168991 no 2975 0.109253599867801 4311 767698 YMR146C TIF34 SGTC_1381 2324-0066 62.1 µM -1.23053459717071 0.115991884965715 no 2976 0.109248489807567 4342 10885928 SGTC_2736 butenafine 14.65 µM -1.23545477222702 0.115043015595866 no 2977 0.108330649485178 4260 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_2195 6536160 144.242 µM -1.23810445755885 0.114534309265641 no 2978 0.107838665638968 4291 3834386 SGTC_2315 7733312 200 µM -1.24077140814425 0.114023907042959 no 2979 0.107345103173715 4223 726316 SGTC_2055 5235184 200 µM -1.24685166351114 0.112866328513054 no 2980 0.106225946493725 4363 2836034 SGTC_142 0335-0849 62.6745 µM -1.24729315478566 0.112782603870649 no 2981 0.106145013228331 4301 3889043 YPR107C YTH1 SGTC_2922 7999257 32.47 µM -1.24817286018693 0.112615908295983 no 2982 0.105983880288759 4290 2988377 SGTC_1744 st037937 38.9 µM -1.24880478807692 0.112496272788062 no 2983 0.105868241135647 4367 1016152 SGTC_1353 1498-1206 8.11 µM -1.25499778749388 0.111328627412718 no 2984 0.104739781572854 4361 6756808 SGTC_1804 st050076 49.1 µM -1.25894102602052 0.110589693509473 no 2985 0.104025816942689 4345 3895976 SGTC_2600 tangeritin 87.95 µM -1.26572585823335 0.109326506420519 no 2986 0.10280562361753 4248 68077 A bioactive flavone. SGTC_2024 5144227 134 µM -1.2658198588192 0.109309078669233 no 2987 0.102788791782812 4333 3475211 SGTC_1125 tnp00248 1.32998 µM -1.26906967554748 0.108707787928167 no 2988 0.102208107330976 4376 24207736 SGTC_1012 4112-3522 18 µM -1.27322970441809 0.107941563263906 no 2989 0.101468271407219 4352 3112398 SGTC_3137 9097352 49.47 µM -1.27378727416972 0.107839162276966 no 2990 0.101369408200014 4366 44120435 SGTC_2148 5546263 113.568 µM -1.27809448768096 0.107050474340621 no 2991 0.100608056167157 4355 792097 SGTC_1788 fluconazole 20 µM -1.27811673309797 0.107046411840516 no 2992 0.100604134877862 4365 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11 SGTC_2295 7971645 200 µM -1.27847586658626 0.106980841591826 no 2993 0.100540844398795 4396 2978226 YKL099C UTP11 SGTC_2250 alverine citrate 130 µM -1.27903215176307 0.10687933277996 no 2994 0.1004428670186 4234 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1 SGTC_1752 st044819 83.042 µM -1.27995943702698 0.106710279771279 no 2995 0.100279701034186 4305 441209 YML126C ERG13 SGTC_2118 5526350 200 µM -1.28090004177961 0.106538995731865 no 2996 0.100114389074459 4382 743594 SGTC_1704 st028805 70.8 µM -1.28363290411903 0.106042468010286 no 2997 0.0996352155344188 4392 2876101 SGTC_2178 5812956 200 µM -1.28441191012596 0.105901238848507 no 2998 0.0994989339159036 4306 5403383 SGTC_2483 5729050 27.16 µM -1.28491893477129 0.105809391352857 no 2999 0.0994103067465483 4372 2865180 SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM -1.28590680776113 0.105630603610869 no 3000 0.099237793762203 4385 2374 Ca(2+)-ATPase inhibitor. SGTC_2413 inermin 26.06 µM -1.28865751411624 0.105133925003972 no 3001 0.0987585894684077 4414 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1 SGTC_313 3474-0040 5.03 µM -1.292332830277 0.104472935951509 no 3002 0.0981209535978281 4368 1043375 YIL048W NEO1 SGTC_3105 9121040 49.47 µM -1.29337507160087 0.104286042704374 no 3003 0.097940683797344 4286 41448907 SGTC_2311 7694451 200 µM -1.29344411032864 0.104273671339641 no 3004 0.0979287511883855 4355 2163142 SGTC_254 nsc-64875 3.808 µM -1.29537040464945 0.103928918647435 no 3005 0.0975962412025136 4356 56993 SGTC_1534 6-azauridine 81.6 µM -1.29743051238695 0.10356113268438 no 3006 0.0972415498176726 4395 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1 SGTC_3086 9117350 49.47 µM -1.29994168807479 0.10311409718359 no 3007 0.0968104777968933 4316 2679265 SGTC_999 SEC7.066 22.7 µM -1.3022254547401 0.102708762997482 no 3008 0.0964196629961164 4319 740511 YDR170C SEC7 SGTC_2927 9011802 47.9 µM -1.30419902699334 0.102359417456085 no 3009 0.0960828657809181 4358 43912568 SGTC_1900 st060200 72.8 µM -1.30557173024192 0.102116942865608 no 3010 0.0958491195963997 4357 688945 SGTC_2307 7538926 6.34 µM -1.30677314532843 0.101905067806208 no 3011 0.0956448841105665 4337 96582 SGTC_350 k064-0020 19.8 µM -1.30738330572236 0.101797585810885 no 3012 0.0955412821144227 4394 2790705 SGTC_1023 4482-3888 16 µM -1.31078842984317 0.101199275758859 no 3013 0.0949646263013311 4391 3303168 SGTC_1455 4262-0120 131 µM -1.31134934746977 0.101100963964247 no 3014 0.0948698817134436 4439 1529587 SGTC_222 nsc-310342 10.666 µM -1.31181695572677 0.101019059680324 no 3015 0.0947909512559987 4402 432556 SGTC_2647 atorvastatin 60.16 µM -1.31194800578582 0.100996114185795 no 3016 0.0947688391989852 4347 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7 SGTC_2949 9072542 2.23 µM -1.31266882810949 0.100869973654302 no 3017 0.094647282906474 4373 16457352 SGTC_2798 7813637 45.45 µM -1.31589648796187 0.100306556957696 no 3018 0.0941043938519189 4374 956368 SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM -1.31790044031288 0.0999579069560694 no 3019 0.0937684891507675 4325 6708514 SGTC_1295 1013-0063 9.78 µM -1.32213254216347 0.0992245105998354 no 3020 0.0930620095752509 4411 6826038 SGTC_1417 3966-0327 90.4 µM -1.32238602793051 0.0991807083521798 no 3021 0.0930198195284253 4461 651118 SGTC_753 1322-0200 289 µM -1.32321697689781 0.0990372198288141 no 3022 0.0928816159280724 4435 5403907 SGTC_117 lucigenin 22.078 µM -1.32374865707395 0.0989454888292468 no 3023 0.0927932664555779 4370 65100 An acridine derivative; a dye stuff and potential carcinogen. SGTC_3111 9122088 49.47 µM -1.32381058503051 0.098934808416342 no 3024 0.0927829799083953 4273 16876704 SGTC_2377 9073351 62.6 µM -1.3241628100341 0.0988740779268904 no 3025 0.0927244895884687 4373 7337946 YHR072W ERG7 SGTC_32 0928-0142 34.1 µM -1.32886797371057 0.0980654299034818 no 3026 0.0919457657585711 4371 2244242 SGTC_1406 3909-7906 11.9 µM -1.32974222917484 0.0979157122718402 no 3027 0.0918016080222754 4409 X1406 SGTC_667 1498-1044 59 µM -1.3349594417536 0.0970257379728772 no 3028 0.0909448105910211 4391 6739982 SGTC_1188 1403-0014 4.57 µM -1.33503648358864 0.0970126404853933 no 3029 0.0909322029851384 4401 9614867 SGTC_2420 aureobasidin a 50 nM -1.34208471922488 0.0958198901214648 no 3030 0.0897842639571918 4463 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1 SGTC_428 3448-4153 16.5 µM -1.34352455495199 0.0955775638810482 no 3031 0.0895510902507197 4354 3834874 SGTC_697 0508-1955 564 µM -1.34522291494307 0.0952923077440607 no 3032 0.0892766291483064 4391 6243113 SGTC_3179 9107801 49.47 µM -1.34536761436422 0.0952680330724946 no 3033 0.089253274163901 4390 4818259 SGTC_46 0329-0187a 2.197 µM -1.34633453640712 0.0951059397763407 no 3034 0.0890973262892478 4421 46494817 SGTC_192 3455-0609 60.9 µM -1.34646699826426 0.0950837499067859 no 3035 0.089075978275817 4462 3769639 SGTC_3031 9088762 49.47 µM -1.34790959568702 0.0948423343764403 no 3036 0.0888437307052435 4378 205253 SGTC_968 1309-0633 340 µM -1.34974880170943 0.0945352026193608 no 3037 0.088548286286604 4432 3761976 SGTC_644 1498-1197 63.3 µM -1.35033577681886 0.094437337286002 no 3038 0.0884541506388646 4424 6741615 SGTC_365 0121-0052 13.6 µM -1.35095411230467 0.0943343241106569 no 3039 0.0883550662634313 4410 3101739 SGTC_2842 9000675 19.48 µM -1.35109047845903 0.0943116170012403 no 3040 0.088333225580383 4419 2989072 SGTC_1647 st011722 22.4 µM -1.35122712818209 0.094288866717146 no 3041 0.0883113435165688 4371 2854783 SGTC_1991 st073000 8.92 µM -1.35489396556233 0.0936798998146125 no 3042 0.0877256712677517 4438 4301969 YIL048W NEO1 SGTC_2582 agaric acid 100 µM -1.35663286821655 0.0933921301841232 no 3043 0.0874489463638885 4008 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase. SGTC_2888 9058547 12.99 µM -1.35783856111072 0.0931929847115829 no 3044 0.0872574580425092 4330 16476514 SGTC_1038 k292-0204 154 µM -1.36105560783773 0.0926631579013888 no 3045 0.0867480584834521 4348 4454212 SGTC_2697 mebhydrolin 72.4 µM -1.36790243528894 0.0915429523296226 no 3046 0.0856713086942503 4451 22530 H1 Histamine receptor antagonist. YIL048W NEO1 SGTC_3174 9107204 49.47 µM -1.36899225815563 0.0913655768071493 no 3047 0.0855008474620066 4436 3938802 SGTC_580 1123-0028 41 µM -1.37473864372292 0.0904345281437981 no 3048 0.0846062430598994 4481 1677248 YPR107C YTH1 SGTC_632 0781-2353 4.65 µM -1.37638783525493 0.0901686261040738 no 3049 0.0843507960676973 4463 6811515 YHR007C ERG11 SGTC_2382 9035899 200 µM -1.37746893949249 0.0899946331980118 no 3050 0.0841836557210754 4414 6462679 SGTC_1551 6-bromo-3'-methylflavone 63.5 µM -1.37759669153332 0.0899740892793849 no 3051 0.0841639214979582 4413 688751 SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM -1.37815511731474 0.0898843292454274 no 3052 0.0840777006335381 4417 6708760 SGTC_3350 9150499 3.57 µM -1.37874655922638 0.0897893348666971 no 3053 0.0839864544108338 4422 4910996 YPR165W RHO1 SGTC_3342 9147791 14.508 µM -1.38099733151545 0.0894285096756936 no 3054 0.0836398905720058 4375 1838168 SGTC_516 3992-2719 87.3 µM -1.38138438324335 0.0893665695781466 no 3055 0.0835804025055817 4329 5350887 YDR037W KRS1 SGTC_748 act1.228 77.9 µM -1.38298787866716 0.089110301292235 no 3056 0.0833342913023904 4404 4421505 YNR035C ARC35 SGTC_2460 5552655 174.22 µM -1.38384767519696 0.0889731153203824 no 3057 0.0832025506954678 4430 5401989 SGTC_13 0199-0087 65 µM -1.38845744895882 0.0882402768924028 no 3058 0.0824988966102167 4530 4589825 SGTC_997 3996-0078 137 µM -1.38874526520872 0.088194670990129 no 3059 0.0824551122421209 4471 735687 SGTC_2704 st078022 71.1 µM -1.38951672297973 0.0880725163718299 no 3060 0.0823378396626108 4455 54697681 SGTC_544 k015-0020 52.4 µM -1.389868194748 0.0880169052680292 no 3061 0.0822844526078358 4456 3008304 SGTC_563 tetrahydrosecaminediol 614 µM -1.39164078957352 0.0877368380105728 no 3062 0.0820156002655329 4467 334274 A psychoactive constituent of the cannabis plant. SGTC_3309 9129340 25.759 µM -1.39424065550958 0.0873272665711128 no 3063 0.0816224723817435 4430 17158987 SGTC_137 0438-0332 85.389 µM -1.39562126489874 0.0871103525044484 no 3064 0.0814142876920225 4374 2063393 YER012W | YPR107C PRE1 | YTH1 SGTC_1073 triclabendazole 3.09 µM -1.39749556419375 0.0868165167598187 no 3065 0.0811322998201362 4461 50248 An antihelmetic and likely tubulin inhibitor. SGTC_1445 4239-0156 97.7 µM -1.39815671813098 0.0867130438962225 no 3066 0.081033005415457 4469 4008346 SGTC_1456 k015-0012 13 µM -1.39969698624361 0.086472344144275 no 3067 0.0808020383395384 4453 2989616 SGTC_2324 6149169 200 µM -1.40063820156353 0.0863255052621658 no 3068 0.0806611456137971 4368 2888231 SGTC_2825 7998094 58.44 µM -1.40442094871152 0.0857372397301149 no 3069 0.0800967681880925 4406 2987815 SGTC_1705 st027868 56.3335 µM -1.40526616910128 0.0856062082903937 no 3070 0.0799710722007097 4370 292948 SGTC_975 1335-0046 28.5 µM -1.40535344816918 0.0855926862800617 no 3071 0.0799581010942996 4441 16486740 SGTC_2621 lithochol-11-enic acid 100 µM -1.411854117982 0.0845900373440254 no 3072 0.0789964599121682 4399 6708711 SGTC_1482 3346-2049 8.48 µM -1.41567372976359 0.0840050323348596 no 3073 0.0784355266555567 4473 3826804 SGTC_1376 2910-0861 41.3 µM -1.41631281564035 0.0839074484402087 no 3074 0.0783419686291102 4395 1112859 SGTC_1511 0906-3109 28.5 µM -1.41810505386951 0.0836342404710176 no 3075 0.0780800479924212 4440 2882180 SGTC_2628 lathosterol 100 µM -1.42052572492311 0.083266296209185 no 3076 0.0777273423966031 4474 6710616 SGTC_335 4077-0256 27.6 µM -1.4221473675906 0.0830204866016687 no 3077 0.0774917371556939 4383 3121989 SGTC_1764 st044502 93.5 µM -1.42891898704113 0.0819999359934038 no 3078 0.0765137597510458 4481 8407 SGTC_22 0964-0034 14.468 µM -1.43034005294984 0.0817869722530493 no 3079 0.0763097222549497 4459 138402 SGTC_1102 cgs 12066b 26.1 µM -1.43046939389356 0.0817676096822483 no 3080 0.0762911719816231 4460 6438352 A 5-HT1B full agonist. SGTC_1373 2887-0003 58.5 µM -1.4336298033432 0.0812955637789275 no 3081 0.0758389669220823 4411 776948 SGTC_2691 st077356 60.2 µM -1.43476465635191 0.0811265621548583 no 3082 0.0756770863117551 4453 2839272 SGTC_1444 4112-3581 28 µM -1.4356013672086 0.0810021295701009 no 3083 0.0755579027407629 4533 2877249 SGTC_2707 st078556 66.6 µM -1.43821745894924 0.0806140032582896 no 3084 0.075186181499946 4388 17250899 SGTC_2894 9048625 32.47 µM -1.43909054810636 0.0804847838743453 no 3085 0.0750624348279966 4478 4092861 SGTC_1872 amphotericin b 148 nM -1.44012294589439 0.0803321883969347 no 3086 0.0749163091518856 4469 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1 SGTC_1909 st060837 51.5 µM -1.44077071399412 0.0802365555084376 no 3087 0.074824734847534 4410 678937 SGTC_1912 st060209 90.8 µM -1.44547875307194 0.0795440704353242 no 3088 0.0741617283853409 4436 688787 SGTC_311 1315-0136 58 µM -1.44882559037655 0.0790545554160007 no 3089 0.0736931476734191 4480 6759207 SGTC_2027 5150920 200 µM -1.45149880596759 0.078665207233763 no 3090 0.0733205072424471 4416 786715 SGTC_1048 3161-0300 24.5 µM -1.45523003168542 0.0781241942091749 no 3091 0.072802794718885 4473 2165101 SGTC_3340 9146634 11.102 µM -1.45802164020962 0.0777212712508375 no 3092 0.0724172891423101 4451 4907387 SGTC_1183 1254-0324 198 µM -1.46040722885411 0.0773782022785074 no 3093 0.0720890936199345 4516 5799357 SGTC_1893 st059353 36.1 µM -1.46081609282547 0.0773195196222696 no 3094 0.0720329591099206 4472 3112488 SGTC_1294 1000-1494 117 µM -1.46144128704863 0.0772298533039491 no 3095 0.0719471885931964 4469 712797 YDL207W GLE1 SGTC_3125 9127534 49.47 µM -1.4663877181844 0.0765232116102766 no 3096 0.0712713451816668 4378 1639235 SGTC_1293 1000-1278 195 µM -1.47078289189857 0.075899458231137 no 3097 0.0706749202810787 4492 678847 SGTC_1285 0929-0069 65.5 µM -1.47709205238721 0.0750108540432928 no 3098 0.0698254818365671 4515 1206237 SGTC_2583 asiatic acid 100 µM -1.4797934473362 0.0746328150830632 no 3099 0.0694641889637749 4479 5320556 A kinase inhibitor; arrests cells at G2/M. SGTC_2435 5706476 10.6 µM -1.48160720610568 0.0743798108590984 no 3100 0.0692224202500719 4471 5725375 SGTC_2331 7980721 200 µM -1.48232408134485 0.0742799935008133 no 3101 0.0691270418413348 4444 2981221 SGTC_3094 9117742 49.47 µM -1.48234403481342 0.0742772166535853 no 3102 0.0691243885328973 4448 17149698 SGTC_2684 capsaicin 100 µM -1.4864735036434 0.0737042385699489 no 3103 0.068576960125775 4511 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_861 0443-0273 110 µM -1.48981165225724 0.0732435334974249 no 3104 0.0681368832234645 4481 6149169 SGTC_3116 9124943 49.47 µM -1.48986147793809 0.0732366736739579 no 3105 0.0681303311241626 4461 41905195 YPL160W CDC60 SGTC_718 1130-0073 349 µM -1.48986174388555 0.0732366370605721 no 3106 0.0681302961532585 4500 6740020 SGTC_2963 9082507 9 µM -1.48994627305054 0.0732250005129206 no 3107 0.0681191816471402 4491 16459611 SGTC_321 4534-3890 65.3 µM -1.49038620271331 0.0731644612653724 no 3108 0.0680613591094465 4486 699746 SGTC_731 3966-0296 387 µM -1.49265980095206 0.0728521989237169 no 3109 0.0677631305171292 4485 660956 SGTC_1866 st057638 64 µM -1.49904662253643 0.0719804734437937 no 3110 0.0669307687407626 4509 688802 SGTC_1332 1480-0653 17.5 µM -1.50213619904039 0.0715616634839285 no 3111 0.0665309689173566 4495 5749438 SGTC_1469 k284-2957 126 µM -1.50306250679289 0.0714364621366424 no 3112 0.0664114630308523 4498 23884841 SGTC_425 3825-7017 13.1 µM -1.50327246513469 0.071408107190815 no 3113 0.0663843987620821 4516 3397440 SGTC_3270 9137563 49.47 µM -1.50774715198206 0.0708058509374908 no 3114 0.0658096262785674 4501 17015724 SGTC_121 0557-0495 61.343 µM -1.51106880397468 0.0703613131782014 no 3115 0.0653854609272354 4537 3104427 SGTC_2358 9037157 4 µM -1.51185689365991 0.0702561585233601 no 3116 0.0652851360767859 4504 2388925 SGTC_26 0302-0163 425.158 µM -1.51213207111647 0.0702194701297498 no 3117 0.0652501337688769 4561 3100915 SGTC_2828 7998861 71.43 µM -1.51382600048642 0.0699939492413388 no 3118 0.0650349881664227 4499 2988188 SGTC_932 2857-0803 154 µM -1.51810887156634 0.0694262360836239 no 3119 0.0644934775335743 4502 674898 SGTC_3007 9078383 71.4286 µM -1.51872767305009 0.0693445053052561 no 3120 0.0644155289846972 4508 6496995 SGTC_2237 6667747 47.222 µM -1.52014131027536 0.0691580713567782 no 3121 0.0642377320215332 4498 729940 YDL015C TSC13 SGTC_1296 1068-0102 11.9 µM -1.52026496063503 0.0691417824299053 no 3122 0.0642221983413161 4509 767053 SGTC_3034 9090421 49.47 µM -1.52095918422354 0.0690503846328078 no 3123 0.0641350401256434 4420 17173761 SGTC_2809 7964133 12.99 µM -1.52463941168637 0.0685674197838514 no 3124 0.0636745307570018 4484 1253665 SGTC_1836 st055642 81 µM -1.53501420159862 0.067219935157823 no 3125 0.0623901698250423 4504 8571 SGTC_3148 9097893 49.47 µM -1.53508630057819 0.0672106430539319 no 3126 0.062381315449737 4486 17174100 SGTC_791 1348-1292 225 µM -1.53659619049671 0.0670162767973108 no 3127 0.0621961130174114 4479 5437054 SGTC_3011 9081274 71.4286 µM -1.53738550813609 0.0669148421012682 no 3128 0.0620994665271294 4511 6625322 SGTC_1298 1079-1278 263 µM -1.53950829082849 0.0666426338812368 no 3129 0.0618401277077021 4494 2840950 SGTC_2040 5100729 123 µM -1.54422562409222 0.066040790818575 no 3130 0.0612668416506763 4543 11840 YJR013W | YDR381W GPI14 | YRA1 SGTC_1145 3546-0597 10.2 µM -1.54723539801924 0.0656590062331328 no 3131 0.0609032465701191 4494 875334 SGTC_545 4218-0007 221 µM -1.54765522128342 0.0656058886461566 no 3132 0.0608526642653501 4520 2840508 SGTC_3153 9100258 49.47 µM -1.55361269224222 0.0648557136062949 no 3133 0.0601384149775164 4446 25236848 SGTC_3043 9092303 49.47 µM -1.55638554079855 0.0645088308508232 no 3134 0.0598082206919519 4534 25236084 SGTC_2444 5485484 36.41 µM -1.56033516943037 0.064017223971504 no 3135 0.0593403482338738 4570 6790631 SGTC_955 1216-0110 33 µM -1.56192897591776 0.0638196711277637 no 3136 0.0591523607480053 4498 3619719 SGTC_1635 st007035 42.4 µM -1.56193704488875 0.063818672183903 no 3137 0.0591514102126621 4479 3716403 SGTC_1284 0929-0043 16 µM -1.56259124553031 0.0637377221766827 no 3138 0.0590743843719999 4526 1239883 SGTC_928 2764-0428 58.7 µM -1.56423331647075 0.0635348861507358 no 3139 0.0588813928729376 4546 662578 SGTC_2123 5259487 200 µM -1.56847191506192 0.0630136369889413 no 3140 0.0583855196629633 4538 2173474 SGTC_373 0844-0104 25.9 µM -1.57604401779062 0.0620907420197471 no 3141 0.0575078296191126 4550 5375804 SGTC_506 n9-isopropylolomoucine 153 µM -1.58063493996433 0.0615363524104581 no 3142 0.0569807660250016 4547 6610355 SGTC_2365 9042475 200 µM -1.59023668075797 0.0603893708571195 no 3143 0.0558907326212351 4572 6464479 SGTC_1360 1598-0022 39.8 µM -1.59360861036826 0.0599905679555651 no 3144 0.0555118623769736 4562 761525 SGTC_1662 st014054 52 µM -1.5942978922424 0.0599093000731928 no 3145 0.0554346647817087 4622 2838777 SGTC_2792 7535235 81.82 µM -1.59684101228165 0.0596102062680282 no 3146 0.0551505756840897 4509 1281891 SGTC_3047 9092122 49.47 µM -1.60066420451903 0.0591627678718473 no 3147 0.0547256567192047 4530 17173831 SGTC_220 paclitaxel 373.376 µM -1.60594212557358 0.0585494118438371 no 3148 0.0541433133066137 4523 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_681 1642-0006 26.6 µM -1.60618906830925 0.0585208369390416 no 3149 0.054116187254728 4577 4446530 SGTC_399 oxolinic acid 75 µM -1.60650244979044 0.0584845898615438 no 3150 0.0540817785573693 4528 4628 A DNA gyrase inhibitor. SGTC_1492 4158-0558 28.5 µM -1.6120831337118 0.0578420513836776 no 3151 0.0534719252189261 4566 3967268 SGTC_2096 5468907 200 µM -1.61390561613072 0.057633424083152 no 3152 0.0532739501558192 4563 759785 SGTC_839 0122-0028 230 µM -1.61405462745757 0.0576163923285959 no 3153 0.0532577888820279 4563 759448 SGTC_166 k072-0058 166.424 µM -1.61830856811262 0.057131841245078 no 3154 0.0527980575541398 4426 5846229 SGTC_3164 9100705 49.47 µM -1.62132619359401 0.056790063386995 no 3155 0.052473850150429 4573 17174235 SGTC_2506 ethyl hematommate 54.16 µM -1.62198542865276 0.0567156128393471 no 3156 0.0524032340710087 4569 3940691 An allergen. SGTC_2998 9066762 71.4286 µM -1.62846838870881 0.0559875507811276 no 3157 0.0517128033938963 4560 4945196 SGTC_560 2332-1943 155 µM -1.63005604963358 0.0558103787412194 no 3158 0.0515448257251032 4554 21177716 SGTC_1951 sophoraflavanone G 9.2 µM -1.63143064699163 0.0556573406984828 no 3159 0.051399741302171 4496 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity. SGTC_1583 clindamycin 39.6 µM -1.63686866973737 0.0550551538819951 no 3160 0.0508289567738277 4540 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis. SGTC_2629 bisabolol 100 µM -1.64052430080246 0.0546532442814405 no 3161 0.0504481000181418 4563 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer. SGTC_2463 5473429 200 µM -1.64498031870016 0.0541664793670083 no 3162 0.0499869349267622 4569 5399405 SGTC_773 4358-1457 44.6 µM -1.64766249027148 0.0538751433572326 no 3163 0.0497109746503678 4560 1186886 SGTC_2682 pyrogallin 40.03 µM -1.64773741062585 0.0538670233965342 no 3164 0.0497032838142044 4574 822798 An ATP competetive kinase inhibitor. SGTC_1150 3909-7983 10.9 µM -1.6477722567702 0.0538632470584777 no 3165 0.0496997070591991 4569 23965914 SGTC_606 k015-0008 38.6 µM -1.64788414009657 0.0538511234822993 no 3166 0.0496882242716258 4625 1970475 SGTC_14 0354-0009 295 µM -1.64983575815935 0.0536399952852274 no 3167 0.0494882664890971 4660 1713507 SGTC_1483 3453-0561 55.9 µM -1.65632834756153 0.0529423356360471 no 3168 0.0488276713947702 4602 4546991 SGTC_1318 1280-3875 124 µM -1.65886532021082 0.0526716892018043 no 3169 0.0485714671179981 4596 373245 SGTC_2907 7721985 69.9 µM -1.66471631795024 0.0520516854273816 no 3170 0.0479846829323527 4572 3267881 SGTC_1134 3477-0009 42.5 µM -1.66474127121945 0.0520490537125557 no 3171 0.0479821926270086 4586 3973534 SGTC_2919 7978188 46.38 µM -1.66972113715394 0.0515259605560076 no 3172 0.0474872748654662 4578 2980291 SGTC_2749 bexarotene 57.39 µM -1.67207447451279 0.0512802210391703 no 3173 0.0472548186483305 4577 82146 An retinoic acid receptor inhibitor. SGTC_2472 5377652 49.4 µM -1.67215077423217 0.0512722693237619 no 3174 0.0472472972624519 4608 1610903 SGTC_2994 9053520 71.4286 µM -1.67287613979291 0.0511967230015405 no 3175 0.0471758409231721 4576 4647384 SGTC_2971 9092186 9.93 µM -1.67304944975865 0.0511786860033817 no 3176 0.0471587808485959 4543 25236400 SGTC_801 0866-0028 10.1 µM -1.67380924429828 0.0510996710897949 no 3177 0.0470840474814433 4621 6849771 SGTC_1378 2093-0007 380 nM -1.67627473072276 0.050843941025619 no 3178 0.0468421960800701 4586 3618014 SGTC_2488 5268135 45.7 µM -1.68303459162574 0.0501480059839298 no 3179 0.0461841975901662 4592 1270356 YLR208W SEC13 SGTC_3278 9139605 49.47 µM -1.68405607897109 0.0500435063549427 no 3180 0.0460854157163598 4554 7958859 SGTC_1275 0867-0008 21.1 µM -1.68469260293355 0.0499784768923704 no 3181 0.04602394720077 4565 3422836 SGTC_3238 9133470 49.47 µM -1.69539655811525 0.0488949868130403 no 3182 0.0450001092093591 4590 3534688 SGTC_2787 5284540 71.43 µM -1.6958886932108 0.0488456261507738 no 3183 0.0449534806697329 4581 736958 SGTC_2138 5575593 77.673 µM -1.69861554476716 0.0485728468250606 no 3184 0.0446958228000619 4594 762213 SGTC_2146 5545642 200 µM -1.70116587179988 0.0483188295920847 no 3185 0.044455922205816 4546 825326 SGTC_223 busulfan 5 mM -1.70485983664091 0.0479527893595817 no 3186 0.0441102842698823 4586 2478 A DNA alkylator. SGTC_49 0717-0965 32.132 µM -1.70497426951224 0.0479414855867429 no 3187 0.0440996116799797 4635 5889349 YGL099W LSG1 SGTC_1227 3909-8010 46.6 µM -1.70731892943798 0.0477103473805066 no 3188 0.0438813947969699 4598 15982272 SGTC_1936 st074407 74.3 µM -1.70767271971796 0.0476755481053248 no 3189 0.0438485433829274 4606 809813 SGTC_306 1672-3436 11.6 µM -1.70970289075264 0.0474762506522553 no 3190 0.0436604139666228 4593 6797378 SGTC_2642 cholecalciferol 100 µM -1.71388680632978 0.0470676301481745 no 3191 0.0432747583058014 4595 9821465 A vitamin D precursor, similar to steriods. SGTC_1161 k007-0610 110 µM -1.72481081546119 0.0460140242980292 no 3192 0.0422807859999487 4538 5843850 SGTC_189 3970-0742 2.116 µM -1.729818927893 0.045537374530251 no 3193 0.0418313157936786 4585 2891807 SGTC_1786 berberine 21.6 µM -1.73131871937685 0.0453954061349198 no 3194 0.0416974672628366 4511 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_1952 st077036 64.1 µM -1.73398553668654 0.0451438479410177 no 3195 0.0414603247256179 4613 2937007 SGTC_276 colchicine 750 µM -1.73529523088391 0.0450207171671746 no 3196 0.0413442630273098 4622 2833 A microtubule depolymerizer. SGTC_2827 7993847 71.43 µM -1.74239147413459 0.044358257124199 no 3197 0.040719983384366 4629 2985692 SGTC_1982 st072467 71.9 µM -1.74259601326971 0.0443392797585183 no 3198 0.0407021034593882 4588 3163533 SGTC_2709 st078560 56 µM -1.74330205736584 0.0442738224805994 no 3199 0.0406404330927636 4576 17250903 SGTC_948 3448-0295 75.3 µM -1.7565163219443 0.0430630372283289 no 3200 0.0395001434754923 4588 678569 SGTC_278 4092-0821 23.9 µM -1.75861079123343 0.0428736062151764 no 3201 0.0393218194080583 4593 877900 SGTC_2201 6605497 169.863 µM -1.7594508321901 0.042797819478281 no 3202 0.0392504822402888 4591 670741 SGTC_2870 9038528 12.99 µM -1.7720877832163 0.0416707530325596 no 3203 0.0381899932870408 4630 6463316 SGTC_771 0250-0039 27.3 µM -1.77683780444272 0.0412533743618839 no 3204 0.0377974649428064 4567 3005115 SGTC_2467 5474540 200 µM -1.78254453028886 0.0407564196580017 no 3205 0.0373302381332627 4608 5413519 SGTC_225 nsc-122657 1.016 µM -1.78866379877373 0.0402289483771091 no 3206 0.0368344882139171 4623 275685 SGTC_2101 5377231 179.231 µM -1.78924806323897 0.0401788770264527 no 3207 0.0367874371457624 4639 2844213 SGTC_2607 solasodine 47.35 µM -1.7973044555551 0.0394935940275101 no 3208 0.0361436496347282 4561 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity. SGTC_2774 tamoxifen 10.92 µM -1.79977937054108 0.039284995078279 no 3209 0.0359477413027267 4612 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  SGTC_282 k297-0036 65.7 µM -1.80026420055046 0.0392442362458857 no 3210 0.0359094653968863 4617 5061378 SGTC_2812 7970281 58.44 µM -1.80196627650902 0.0391014180333059 no 3211 0.0357753557636964 4636 2233435 SGTC_1276 0871-0068 94.2 µM -1.8082836258992 0.0385750355245742 no 3212 0.0352811844843157 4642 3414906 SGTC_610 4215-0184 155 µM -1.80963576042959 0.0384631247857327 no 3213 0.0351761452636536 4645 5605015 SGTC_2939 9044578 71.43 µM -1.81451732277857 0.0380612978551614 no 3214 0.0347990591275885 4567 2653634 SGTC_3216 9129716 49.47 µM -1.82087708090471 0.0375429364885073 no 3215 0.0343127719177836 4545 8056934 SGTC_700 3453-2283 142 µM -1.82206151525023 0.037447037130583 no 3216 0.0342228261422752 4664 565664 SGTC_2557 derrustone 83.84 µM -1.82972808136735 0.0368311312053083 no 3217 0.0336453048183576 4609 629853 An antioxidant. SGTC_872 0588-0139 234 µM -1.84265117891245 0.0358116994522956 no 3218 0.0326899782033073 4614 2047100 SGTC_3001 9076041 71.4286 µM -1.84276655919385 0.0358027029466993 no 3219 0.0326815506461712 4635 16004211 SGTC_2996 9066192 71.4286 µM -1.84542172057951 0.0355961841365713 no 3220 0.0324881079565384 4614 6472854 SGTC_1864 st057645 30.4 µM -1.84799953034079 0.0353966169979893 no 3221 0.0323012053884689 4680 688666 SGTC_2306 7482397 179.52 µM -1.86113877744166 0.0343936207914512 no 3222 0.0313622906891864 4628 891448 SGTC_688 0527-0193 473 µM -1.86331358219112 0.0342298796985688 no 3223 0.0312090801651221 4667 4007154 SGTC_2638 epoxomicin 18 µM -1.86384168554883 0.0341902156268514 no 3224 0.0311719699335725 4615 9915668 A protesome inhibitor. SGTC_730 1436-0052 41.2 µM -1.86501509163047 0.0341022202650425 no 3225 0.031089644427116 4662 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2 SGTC_3023 9089636 49.47 µM -1.8673982258294 0.0339240787996508 no 3226 0.0309229986943614 4704 17249241 SGTC_3151 9099821 49.47 µM -1.87495567841056 0.0333642082568839 no 3227 0.0303994106090189 4590 17174189 SGTC_2060 5238662 140 µM -1.87733924101561 0.0331892157567751 no 3228 0.0302358065951783 4623 790130 SGTC_1193 1488-0126 41.5 µM -1.87881197998322 0.0330814710044045 no 3229 0.0301350853366309 4636 1384710 SGTC_2837 9008476 45.46 µM -1.87917257162172 0.0330551342893748 no 3230 0.0301104667523328 4618 2992805 SGTC_2013 4024628 200 µM -1.89158422890369 0.0321590965523732 no 3231 0.0292731994128945 4644 5230760 SGTC_3282 9108498 15.4605 µM -1.89218400695041 0.0321163095349506 no 3232 0.0292332342393982 4633 16459645 SGTC_2150 5556613 200 µM -1.89244713794978 0.0320975531110085 no 3233 0.0292157152681336 4672 743190 SGTC_2163 5671233 125 µM -1.89269061711181 0.0320802055600791 no 3234 0.0291995124634308 4602 701023 SGTC_1721 st082152 9.2685 µM -1.89746884577229 0.0317413271046038 no 3235 0.0288830433903668 4604 5296051 SGTC_1341 1486-1360 280 µM -1.9011090358829 0.0314851494171211 no 3236 0.0286438661536244 4662 3976547 SGTC_3336 9143619 71.43 µM -1.91569956179548 0.0304754406568554 no 3237 0.0277016741263397 4657 45595730 SGTC_3138 9097216 49.47 µM -1.92140136255444 0.0300882176309253 no 3238 0.0273405634525805 4614 25237486 SGTC_165 k038-0023 64.381 µM -1.92243056087702 0.0300187587570928 no 3239 0.0272758016117186 4624 46368543 SGTC_2705 st078069 42.8 µM -1.93693702783949 0.0290538069487868 no 3240 0.0263765207498706 4663 1530061 SGTC_1901 st060216 58.6 µM -1.93937410188254 0.0288942522972498 no 3241 0.0262279008426927 4649 688792 SGTC_1759 st043059 70 µM -1.95485922349313 0.0278973768674579 no 3242 0.0252998443087755 4685 669426 SGTC_1702 st027038 51 µM -1.9563511446502 0.0278028641094821 no 3243 0.0252119015753307 4705 5521182 SGTC_2784 7567673 72.73 µM -1.95675684099641 0.0277772095530252 no 3244 0.0251880317604068 4606 3471247 SGTC_2789 5281112 71.43 µM -1.95740712201689 0.0277361296222999 no 3245 0.0251498109101807 4664 765948 SGTC_473 2-arachidonoylglycerol 10 µM -1.95894459078349 0.0276392050649319 no 3246 0.025059638086803 4550 5282280 An endocannabinoid. SGTC_148 3253-0744 288.01 µM -1.96047690194207 0.0275428866990594 no 3247 0.0249700375710821 4580 6893655 SGTC_1398 3558-0053 112 µM -1.96161810069583 0.0274713349053039 no 3248 0.0249034816510327 4683 4532369 SGTC_3231 9132313 49.47 µM -1.96602234365738 0.0271966458331385 no 3249 0.0246480148388133 4665 4905967 SGTC_2648 atorvastatin 78.68 µM -1.96728157943805 0.0271185308747193 no 3250 0.0245753787434208 4688 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11 SGTC_674 0498-0004 451 µM -1.96763052776507 0.0270969175031883 no 3251 0.0245552822836034 4654 4231473 SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM -1.97099704491115 0.026889137494912 no 3252 0.0243621069129537 4613 5355888 SGTC_1522 st012842 45.6 µM -1.97737065707811 0.02649940333132 no 3253 0.0239998741201276 4528 3491067 YOR116C RPO31 SGTC_2233 sulbentine 40.3845 µM -1.97983904427311 0.0263497394984761 no 3254 0.023860808781034 4678 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58 SGTC_1236 0330-0013 258 µM -1.98182571043865 0.0262297972309411 no 3255 0.0237493754244778 4695 4617066 SGTC_3272 9137413 49.47 µM -1.98513357185344 0.0260311024794662 no 3256 0.023564806268495 4637 17614870 SGTC_3166 9102297 49.47 µM -1.99472421238592 0.0254621216788975 no 3257 0.023036483569285 4686 25237072 SGTC_1874 staurosporine 7.6 µM -2.00474411065894 0.024878837355269 no 3258 0.0224952051006615 4682 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1 SGTC_1618 st003135 44.5 µM -2.01383552221589 0.0243593389991423 no 3259 0.0220134024434201 4676 1270615 SGTC_1768 st044301 37.178 µM -2.0139222252549 0.0243544288262028 no 3260 0.0220088498532284 4700 3931349 SGTC_1379 2144-0755 36.5 µM -2.01398924708685 0.0243506338103321 no 3261 0.0220053312256181 4693 5392327 SGTC_3065 9113888 49.47 µM -2.02553455141119 0.0237042661103342 no 3262 0.0214062521596546 4692 16648368 SGTC_616 4092-0450 108 µM -2.03723039356447 0.0230642423874425 no 3263 0.0208134797099034 4706 787165 SGTC_2093 5331342 194.4 µM -2.03823971066884 0.0230096988483313 no 3264 0.0207629829700847 4699 33839 SGTC_1592 4',5'-dihydroxyflavone 8.85 µM -2.04242302276693 0.022784789344622 no 3265 0.0205547939724014 4685 688669 SGTC_3332 9141069 11.198 µM -2.06291653257521 0.0217095789525039 no 3266 0.0195602795401272 4656 17332883 SGTC_370 0180-0345 38.7 µM -2.0660081812593 0.0215511543193681 no 3267 0.0194138535466723 4590 3989527 SGTC_1934 st074720 32.6 µM -2.07625709963486 0.0210329422660414 no 3268 0.0189350893892712 4656 17250992 SGTC_150 3970-0969 77.2 µM -2.08273722370526 0.0207107620540158 no 3269 0.0186375912422875 4693 6615640 SGTC_2241 6772625 37.8075 µM -2.0838484892238 0.0206559338665342 no 3270 0.0185869755411444 4537 2285411 SGTC_3118 9124250 49.47 µM -2.09216343686159 0.0202495752598711 no 3271 0.0182119490041148 4695 1504786 SGTC_2105 5350118 200 µM -2.09561173964671 0.020083052927722 no 3272 0.0180583234814503 4688 2133313 SGTC_590 k048-0076 22.4 µM -2.09771924500285 0.0199818521421185 no 3273 0.0179649769014253 4722 6832814 SGTC_355 1311-2252 105 µM -2.10253411744254 0.0197522679432715 no 3274 0.0177532571327838 4669 5338538 SGTC_1666 st014829 29 µM -2.10485228720687 0.0196425332562445 no 3275 0.0176520840290959 4728 3858230 SGTC_1888 azatryptophan 97.5 µM -2.10578055832826 0.0195987372594259 no 3276 0.0176117091891706 4715 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides SGTC_2083 5306046 65.942 µM -2.11265159568899 0.0192771319201286 no 3277 0.0173152995559292 4716 539837 SGTC_2255 7941087 197.44 µM -2.11464609146409 0.0191846218145746 no 3278 0.0172300610842351 4731 935561 SGTC_3252 9135871 49.47 µM -2.11846740720824 0.019008432792603 no 3279 0.0170677511916071 4717 17682838 SGTC_2204 7233102 200 µM -2.11985089518795 0.0189449846457507 no 3280 0.0170093108108619 4729 2172480 SGTC_3316 9136639 10.545 µM -2.12268484371239 0.0188155792020209 no 3281 0.0168901349520373 4719 4903665 SGTC_875 0709-0210 25.7 µM -2.12272509844145 0.0188137464975269 no 3282 0.0168884472788651 4705 6251364 SGTC_957 1187-1561 14.1 µM -2.12363746458894 0.0187722492973441 no 3283 0.0168502351261702 4657 1538454 SGTC_2473 5854593 8.94 µM -2.12649152135993 0.0186429406357748 no 3284 0.0167311772415752 4707 2872951 SGTC_2608 thymoquinone 42.66 µM -2.15070743891321 0.0175759872361409 no 3285 0.0157496494223205 4673 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC). SGTC_2670 beta-carotene 100 µM -2.1588877273763 0.0172275436313417 no 3286 0.0154294391100148 4735 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.) SGTC_1265 0819-1001 68.8 µM -2.16671399049736 0.0168997212263873 no 3287 0.0151283345745027 4668 3106768 SGTC_1966 st070145 16.1 µM -2.1670198035003 0.0168870205272235 no 3288 0.0151166720668753 4712 3748532 SGTC_814 3342-0569 96 µM -2.18005306688543 0.0163532718335255 no 3289 0.01462676407654 4739 4346283 SGTC_607 4491-0986 66.8 µM -2.18279703706245 0.0162427584208441 no 3290 0.0145253799903794 4713 698981 YDR232W HEM1 SGTC_1774 st048371 48.465 µM -2.19551950141335 0.0157386828078616 no 3291 0.0140631767836447 4721 4242727 SGTC_1863 st057641 20.1 µM -2.19767270898446 0.0156547122113081 no 3292 0.0139862188555677 4744 3921635 SGTC_862 0452-0056 10.2 µM -2.22062307252846 0.0147833215046705 no 3293 0.0131882508706206 4707 1575396 YLR359W | YHR072W ADE13 | ERG7 SGTC_1930 st074634 34.3 µM -2.2297432341191 0.0144488081924097 no 3294 0.0128822469453492 4668 684253 YOR116C RPO31 SGTC_469 w7 172 µM -2.2337196048853 0.0143050134612217 no 3295 0.0127507641065899 4769 45115570 A P450 inhibitor. SGTC_2032 5185112 25.99 µM -2.23569555220559 0.0142340182025477 no 3296 0.0126858602948879 4664 5718189 SGTC_464 bw-b 70c 158 µM -2.24184375471263 0.0140150530957872 no 3297 0.0124857361200533 4717 5353454 SGTC_419 nsc-638432 893 µM -2.24297353061485 0.0139751340683882 no 3298 0.0124492607224117 4721 368090 SGTC_61 0978-8327 98.565 µM -2.25018519341219 0.0137226227862549 no 3299 0.0122185959051153 4693 6150059 YHR072W ERG7 SGTC_3224 9130643 49.47 µM -2.2526342189976 0.0136377718728092 no 3300 0.0121411108442143 4713 17644395 SGTC_2829 7992743 58.44 µM -2.25335038969267 0.0136130445586125 no 3301 0.0121185324614954 4694 16462845 SGTC_194 1486-1323 56.904 µM -2.2548893879311 0.0135600382524423 no 3302 0.0120701362942134 4775 5178754 SGTC_1769 st044406 64.4 µM -2.25848830353755 0.0134367790096333 no 3303 0.0119576164880543 4729 670903 SGTC_1144 3486-0183 12.5 µM -2.27498640927592 0.0128840403112919 no 3304 0.0114533725654017 4747 6744069 SGTC_733 4069-0007 56.1 µM -2.28244862319359 0.0126405619197246 no 3305 0.011231433723751 4727 5717425 YNL287W SEC21 SGTC_1171 0368-0077 21.4 µM -2.28838373840106 0.0124497629943059 no 3306 0.0110575919005217 4738 3239779 SGTC_1550 gossypolone 36.6 µM -2.28874438710009 0.0124382498597798 no 3307 0.0110471042008908 4748 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_3290 9121031 71.43 µM -2.29351741348903 0.0122867449502511 no 3308 0.0109091169984362 4726 17014854 SGTC_977 1348-1378 135 µM -2.2994562132773 0.0121004706430571 no 3309 0.0107395235248317 4722 X977 SGTC_1931 st074438 57.1 µM -2.34116791895283 0.0108598188022481 no 3310 0.0096117594481048 4738 2787313 SGTC_662 k832-1615 104 µM -2.36247358458676 0.0102699507530625 no 3311 0.0090767175558639 4755 5878478 SGTC_1526 st051518 75 µM -2.36815381651345 0.0101174848277832 no 3312 0.00893855090993205 4728 673993 SGTC_1299 1079-1439 3.74 µM -2.37205364077303 0.0100139545487772 no 3313 0.00884476118384802 4759 323161 SGTC_1313 1220-0047 237 µM -2.3729483931456 0.009990332007775 no 3314 0.00882336466828175 4759 3528706 SGTC_2257 7960413 200 µM -2.38309744779519 0.00972577104796997 no 3315 0.00858382458098804 4765 2974689 YIL048W NEO1 SGTC_199 4063-0024 41.6 µM -2.39933878252925 0.00931512866134184 no 3316 0.00821235533370948 4783 306215 SGTC_2056 5235370 200 µM -2.40394143847486 0.0092015499649858 no 3317 0.00810968565207224 4697 5511916 SGTC_1280 0880-0253 10.1 µM -2.41173581693967 0.00901197289650564 no 3318 0.00793839047912353 4755 6836607 SGTC_915 methyl methanesulfonate (MMS) 110 mM -2.41293027948004 0.00898322520242561 no 3319 0.00791242318074446 4748 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks. SGTC_2443 5493264 126.67 µM -2.4300050286745 0.00858097527685505 no 3320 0.00754930667254086 4772 5340055 SGTC_976 1348-1067 47.6 µM -2.44837327890962 0.00816597799042886 no 3321 0.00717514495446851 4769 5310671 YGL099W LSG1 SGTC_1480 1070-0044 41.2 µM -2.48261380595852 0.00743924304211671 no 3322 0.00652111997024572 4787 3124987 SGTC_3133 9127736 49.47 µM -2.5060706975198 0.00697486874996147 no 3323 0.00610406036330217 4750 27243420 SGTC_2601 securinine 100 µM -2.51551520161072 0.00679524475845675 no 3324 0.00594292756878853 4737 442872 A GABA receptor antagonist. SGTC_3182 9108849 49.47 µM -2.51968454549578 0.00671725731941499 no 3325 0.00587300246436731 4750 17133045 SGTC_2811 7967822 32.47 µM -2.5214262774669 0.00668491321354365 no 3326 0.00584400821144901 4751 2232244 SGTC_2087 5276107 200 µM -2.52338900787113 0.00664863017234483 no 3327 0.00581148727709786 4765 144405 SGTC_2239 6685329 187.64 µM -2.52858099101024 0.00655348915600615 no 3328 0.00572623298923175 4740 805680 SGTC_2933 9026794 32.47 µM -2.54505497848978 0.00625953258170357 no 3329 0.00546302670252809 4739 17586027 SGTC_3213 9129884 49.47 µM -2.56205189634806 0.00596854109373151 no 3330 0.0052027884301216 4736 17190742 SGTC_615 k087-0205 167 µM -2.56572433365495 0.00590726682496749 no 3331 0.00514803093247436 4768 9642773 SGTC_446 go6976 132 µM -2.58248297648782 0.00563467582993602 no 3332 0.00490461007181869 4770 3501 A protein kinase C inhibitor. SGTC_525 k781-2675 26.7 µM -2.6053820167891 0.00528028133383123 no 3333 0.00458859370648709 4738 3651118 YDL195W SEC31 SGTC_1001 4048-4355 44.4 µM -2.62562631312239 0.0049836317359819 no 3334 0.00432448558910782 4772 21824233 SGTC_1950 st077106 7.18 µM -2.68449755945962 0.00420353114695397 no 3335 0.00363194568232093 4741 13831864 SGTC_696 1560-0013 611 µM -2.70603478059425 0.00394665794237859 no 3336 0.00340459569959996 4781 1650269 SGTC_391 gliotoxin 8.33 µM -2.72759294489451 0.00370370621685637 no 3337 0.00318991407303793 4784 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion SGTC_1933 st074711 15.9 µM -2.77466503940368 0.00321925546996543 no 3338 0.00276292943429811 4768 17250958 SGTC_3128 9127691 49.47 µM -2.77915086139496 0.00317620387616584 no 3339 0.00272506034306547 4775 41316314 SGTC_122 0236-0016 402.397 µM -2.81720390109468 0.00283133013252029 no 3340 0.00242218800400873 4775 6808838 SGTC_3044 9093193 49.47 µM -2.82737756244002 0.00274503863163651 no 3341 0.00234654791226952 4758 25236277 SGTC_956 1185-0240 191 µM -2.84355644487854 0.00261269205605264 no 3342 0.00223065532408115 4767 1416193 SGTC_395 anisomycin 6.25 µM -2.85457829653995 0.00252586160263001 no 3343 0.00215470039347793 4785 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_3189 9110682 49.47 µM -2.87341211330819 0.00238350749127267 no 3344 0.00203032020100625 4779 17122418 SGTC_2856 9022925 19.48 µM -2.9486900260926 0.00188419799087278 no 3345 0.00159561940441893 4765 4944862 SGTC_62 0180-0423 3.232 µM -2.98614071198998 0.0016730329160051 no 3346 0.0014126130522903 4774 30102 YGL099W LSG1 SGTC_372 0155-0182 15.9 µM -3.03094418978786 0.00144883648628283 no 3347 0.00121895152705117 4695 771486 SGTC_619 1652-1634 108 µM -3.14747008735243 0.000988063459079979 yes 3348 0.000823449778062561 4787 5400454 SGTC_978 1416-0512 87.4 µM -3.24124307722318 0.000719605174771605 yes 3349 0.000595048285060302 4797 6814003 SGTC_1963 st076565 50.3 µM -3.25455273238087 0.000687491890397671 yes 3350 0.000567855367683585 4802 4914280 SGTC_2127 5253358 187.912 µM -3.29520814745121 0.000597403970975968 yes 3351 0.000491744015209525 4788 20612 SGTC_2985 9022375 71.43 µM -3.31141640977002 0.000564631877416548 yes 3352 0.00046412483778317 4786 4939335 SGTC_1940 st075990 51.1 µM -3.46629430515966 0.00032533835105594 yes 3353 0.000263842663169106 4795 1084979 SGTC_462 ag-879 158 µM -3.51488757283297 0.000272416831655505 yes 3354 0.000219970097231866 4800 6809654 Ag-879 is a 5-Lipoxygenase inhibitor. SGTC_1954 st077032 68.9 µM -3.69876258976961 0.000136426561909305 yes 3355 0.000108326565904756 4797 698907 SGTC_368 fentichlor 4.58 µM -3.93118636949768 5.44200390479486e-05 yes 3356 4.22638565743759e-05 4802 7329 A pesticide.