SGTCid condition conc unit HFM1|YGL251C.score HFM1|YGL251C.strain.pval HFM1|YGL251C.strain.significant HFM1|YGL251C.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene SGTC_470 aa-861 153 µM 5.86241336836141 4.51443533488749e-08 yes 1 2.28093815600546e-09 24 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor. SGTC_955 1216-0110 33 µM 5.68951750577884 1.06559986480051e-07 yes 2 6.36994147299894e-09 34 3619719 SGTC_2053 5265679 138 µM 5.62226362632688 1.47860247337161e-07 yes 3 9.4235676643474e-09 2 764595 SGTC_2630 antimycin a 100 µM 5.41687074277288 3.93100852069862e-07 yes 4 3.03255768329626e-08 16 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain. SGTC_2457 5731572 11.68 µM 4.92002197241327 3.63789713842787e-06 yes 5 4.32672487021901e-07 8 2865357 SGTC_960 1222-0186 7.7 µM 4.85624668409422 4.77164930230901e-06 yes 6 5.98158259239436e-07 15 3126296 SGTC_749 1000-0129 128 µM 4.61314643548685 1.30266889254675e-05 yes 7 1.98309332261981e-06 7 708470 SGTC_674 0498-0004 451 µM 4.34858605013095 3.68365146473833e-05 yes 8 6.85090283502167e-06 16 4231473 SGTC_625 k213-0058 121 µM 4.24023382275668 5.54889161608324e-05 yes 9 1.11643535565652e-05 86 3655420 SGTC_750 4073-0104 132 µM 4.10676215520397 9.0747948877573e-05 yes 10 2.00622008154096e-05 10 22330957 SGTC_2641 levomentholum 100 µM 3.96450300617634 0.000150941440894168 yes 11 3.67745100079583e-05 8 16666 SGTC_1893 st059353 36.1 µM 3.96260239883586 0.00015195459339948 yes 12 3.70685961468854e-05 25 3112488 SGTC_2629 bisabolol 100 µM 3.84261692115034 0.000230478640058638 yes 13 6.08646956635422e-05 23 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer. SGTC_900 1112-0045 141 µM 3.77904744814855 0.00028608309384005 yes 14 7.87147137165791e-05 27 56211 YIL048W NEO1 SGTC_2648 atorvastatin 78.68 µM 3.75914348378837 0.000305912944557497 yes 15 8.52480212894457e-05 24 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11 SGTC_2461 5755302 26.15 µM 3.68104831175254 0.000396730187450003 yes 16 0.000116138491948733 46 2788904 SGTC_832 4083-0019 164 µM 3.6743190347091 0.000405626535592532 yes 17 0.000119242299167961 117 1990758 SGTC_2489 cantharidin 73.42 µM 3.66340719521745 0.000420446725363624 yes 18 0.000124441207550602 57 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_62 0180-0423 3.232 µM 3.63995250426172 0.000454017774809292 yes 19 0.000136344167560731 28 30102 YGL099W LSG1 SGTC_2332 7982454 138.89 µM 3.57930745184637 0.000552674255440646 yes 20 0.000172252985905755 68 2981748 SGTC_1082 camptothecin 424.86 nM 3.57463109026889 0.000561051095465534 yes 21 0.000175361028933732 57 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_66 0109-0187 42.4 µM 3.56923278368508 0.000570867064513867 yes 22 0.000179014097257751 50 759417 SGTC_739 1486-1183 203 µM 3.4496581505981 0.000833405879226117 yes 23 0.000280648422033683 33 4346692 SGTC_1611 st001856 99.4 µM 3.42791789895625 0.000891688950295495 yes 24 0.000304114686456778 34 647478 SGTC_2454 5-benzylidenerhodanine 10.36 µM 3.37394362251734 0.00105295090048646 no 25 0.000370497710305812 71 1273210 SGTC_2958 9077254 16.72 µM 3.36958978693418 0.00106706019425301 no 26 0.000376400805246764 48 16457351 SGTC_2723 salbutamol 83.58 µM 3.29746586277088 0.0013274651750121 no 27 0.000487807667181731 16 9884233 β2-adrenoceptor agonist SGTC_3100 9120536 49.47 µM 3.29706091220029 0.00132907857986092 no 28 0.000488511547895927 28 16421196 SGTC_952 1185-0122 232 µM 3.29204027475752 0.00134923121660536 no 29 0.000497316833650374 45 678600 SGTC_1349 flufenamic acid 69 µM 3.28450632409849 0.00137999645830512 no 30 0.000510806026931466 37 3371 A non-steroidal anti-inflammatory. SGTC_660 4031-1742 102 µM 3.25202797094634 0.00152009470217692 no 31 0.000572923725241488 86 6738706 SGTC_2978 9011784 42.97 µM 3.22428685370432 0.00164990152324996 no 32 0.000631434144924058 66 2994934 SGTC_3267 9137951 49.47 µM 3.22372982488339 0.00165260840922517 no 33 0.000632663590951913 19 16643986 SGTC_2213 7173844 200 µM 3.20618092917652 0.00173998630042342 no 34 0.000672546924264423 41 892728 SGTC_800 3448-7362 155 µM 3.13606804447454 0.0021326259690444 no 35 0.00085614735268252 247 15991913 SGTC_471 1-acyl-paf 4 µM 3.12147835561121 0.00222380420167714 no 36 0.000899727376006522 57 16759367 SGTC_244 nsc-207895 1.295 µM 3.11322585219028 0.00227692865831559 no 37 0.000925271722333525 29 42640 SGTC_1994 st072947 40.9 µM 3.06383630906881 0.00261960318734412 no 38 0.00109259219708233 55 5286565 YDL195W SEC31 SGTC_2701 st077767 14.721 µM 3.01987345887376 0.00296310727819609 no 39 0.0012644015749555 96 5721188 SGTC_672 1441-0018 53.7 µM 3.00649235489101 0.00307543925208657 no 40 0.00132140349581683 48 251141 SGTC_1692 fluoroquinolonic acid 71 µM 3.00001072917555 0.00313121801323407 no 41 0.00134985048231571 27 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2 SGTC_3283 9109332 35.8195 µM 2.97150299274499 0.00338751123227767 no 42 0.00148172992834875 39 17027281 SGTC_1519 esterone 74 µM 2.9479476414849 0.00361333958394306 no 43 0.00159945619840616 66 698 A steroid. SGTC_204 PMA1.184 62.41 µM 2.94769953366912 0.00361578847676669 no 44 0.00160074034314966 76 2252213 YGL008C PMA1 SGTC_9 0092-0002 10.449 µM 2.92200477113706 0.00387761309633535 no 45 0.00173893106416728 81 759368 SGTC_1487 3970-0795 2.82 µM 2.91219527969362 0.00398196821518623 no 46 0.00179449092463766 57 3765103 SGTC_1178 0988-0033 191 µM 2.8807725478095 0.00433338905444854 no 47 0.00198350902392172 92 5392207 SGTC_1197 1601-0112 267 µM 2.86862136573965 0.0044765500132217 no 48 0.00206132498703297 81 7350313 SGTC_3102 9121669 49.47 µM 2.86839062786599 0.0044793088786049 no 49 0.00206282906561993 39 41905072 SGTC_2543 pimpinellin 60.67 µM 2.86081729003208 0.00457070807090692 no 50 0.00211275247133389 77 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo. SGTC_203 k066-0004 30.888 µM 2.82305201297915 0.00505178861777958 no 51 0.00237844268288317 84 6795412 SGTC_512 prima-1 270 µM 2.79339618614554 0.0054606434459793 no 52 0.00260788838046581 70 322968 A re-activator of the apoptotic function of mutant p53. SGTC_246 cycloheximide 667 µM 2.77717368970726 0.00569652107711709 no 53 0.00274169340518257 61 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells. SGTC_214 4373-3496 70 µM 2.77141994342588 0.00578232918489912 no 54 0.00279061973726057 152 3779166 SGTC_3044 9093193 49.47 µM 2.76445410342543 0.00588774722624146 no 55 0.00285090639014391 97 25236277 SGTC_3129 9127257 49.47 µM 2.7583782261454 0.00598108512977642 no 56 0.00290444717548455 83 837894 SGTC_1238 0333-0287 48.8 µM 2.73151071669434 0.00640973508950208 no 57 0.00315223452908887 99 7226 SGTC_1007 4101-0031 70 µM 2.72482338781178 0.00652056312015067 no 58 0.00321679456258648 77 1146276 SGTC_491 tetrandrine 80.3 µM 2.68138232598431 0.00728266035440374 no 59 0.00366593478573149 51 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_1488 4013-0813 75.9 µM 2.67145268740665 0.00746751018427305 no 60 0.00377618592091934 39 2910057 SGTC_3264 9137442 49.47 µM 2.64754949898151 0.00792953898887371 no 61 0.00405387446453874 57 17015726 SGTC_864 0469-0573 172 µM 2.6395575806543 0.0080895287132103 no 62 0.00415071598623522 98 689425 SGTC_3104 9120930 49.47 µM 2.63438107041084 0.00819466462619906 no 63 0.00421454136593505 79 17014836 SGTC_1676 st018489 23.4 µM 2.63295855821229 0.00822376557973224 no 64 0.00423223373399059 116 3696235 SGTC_2937 9044753 11.33 µM 2.6066463639458 0.00877865544372176 no 65 0.00457168687012462 132 6465530 YGL099W LSG1 SGTC_3249 9135183 49.47 µM 2.60033082754873 0.00891662851645061 no 66 0.00465669633542805 94 4902779 SGTC_2236 dapsone 200 µM 2.58966203222592 0.00915402420592685 no 67 0.00480350995084065 75 2955 A bacterial DFR inhibitor. An anti-cancer agent. SGTC_2997 9067075 71.4286 µM 2.57804672109627 0.00941875519503914 no 68 0.004968028131924 157 27209819 SGTC_1670 st016595 4.04 µM 2.55913050724835 0.0098642267503657 no 69 0.00524671697319088 92 597879 SGTC_2005 4024620 188 µM 2.55545727462135 0.00995283224860135 no 70 0.00530241896673568 111 236743 SGTC_3296 9122258 64.045 µM 2.5494717454374 0.0100987036858461 no 71 0.00539431264102936 106 4730474 SGTC_830 4076-0286 57.8 µM 2.54195767141688 0.0102844651111581 no 72 0.00551167611672015 228 6866659 SGTC_412 gemfibrozil 100 µM 2.53569456684403 0.0104415702218765 no 73 0.00561122836503483 61 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels. SGTC_1066 ketoconazole 628 nM 2.51404758924008 0.011000786443105 no 74 0.00596771635378073 118 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W SGTC_465 cgp-37157 41 µM 2.50280032685724 0.0113014968400372 no 75 0.0061607518361574 58 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange. SGTC_1829 berberine 14.4 µM 2.50018287620383 0.0113724939879042 no 76 0.00620646054939269 99 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_1355 1499-0035 1.68 µM 2.49900552822818 0.0114045551706234 no 77 0.00622711840970921 115 1548538 SGTC_2764 methyldopa 94.69 µM 2.49395004188464 0.0115431188144743 no 78 0.00631651617726172 123 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent. SGTC_940 3232-1287 54.8 µM 2.48714118278638 0.011732049043403 no 79 0.00643871417301424 143 1585493 YIL048W NEO1 SGTC_2729 fluphenazine 10.66 µM 2.47108853255794 0.0121881275885714 no 80 0.00673512330939898 108 3372 An atypical antipsychotic. SGTC_2411 st077133 39.94 µM 2.46398957483219 0.0123946700693825 no 81 0.00687000538928512 149 1403142 YNL221C POP1 SGTC_496 calpeptin 138 µM 2.46189984200007 0.0124560450124023 no 82 0.00691016274283391 111 73364 A calpain inhibitor. SGTC_1361 1608-0041 5.61 µM 2.46060353976042 0.0124942492095218 no 83 0.00693517717480921 113 X1361 SGTC_2649 anisomycin 9.56 µM 2.4558145107989 0.0126362710231189 no 84 0.00702828455265533 66 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_3052 9092717 49.47 µM 2.4486662600259 0.012850855709605 no 85 0.00716931187476852 144 25237534 SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM 2.43469390577192 0.013279408694703 no 86 0.0074521958901787 210 6708739 YPR165W RHO1 SGTC_145 3737-0113 38.366 µM 2.43242663532968 0.0133501008814451 no 87 0.00749901477598891 213 6849351 SGTC_765 1319-0117 244 µM 2.43009406713667 0.0134231679656331 no 88 0.00754745227567891 102 3487746 YGL099W LSG1 SGTC_1459 k035-0031 35.7 µM 2.41289915576836 0.0139725260293691 no 89 0.00791309885290652 102 3877128 YMR208W ERG12 SGTC_2522 biochanin a 4.94 µM 2.4030333406606 0.0142963955229343 no 90 0.00812985245660688 101 5280373 A possible chelator. SGTC_385 1494-0393 12.4 µM 2.39499300907689 0.0145651008517338 no 91 0.00831034108443795 143 3090647 SGTC_2972 9093619 59.92 µM 2.37493322351169 0.0152545116229281 no 92 0.00877606262567818 139 25236256 SGTC_3333 9141820 12.094 µM 2.36416343420829 0.015636077567106 no 93 0.00903541932567197 102 1939433 SGTC_720 r052-1644 49.9 µM 2.36200964491383 0.0157133595949571 no 94 0.00908808465694493 125 1422863 YOR257W CDC31 SGTC_890 0929-0006 47.2 µM 2.33875517960318 0.0165688540869029 no 95 0.00967405378785039 129 1378169 SGTC_758 0868-0029 16 µM 2.33519912176094 0.0167031277788534 no 96 0.0097665105018954 111 762687 SGTC_3326 9140064 16.379 µM 2.32922353118236 0.0169308576578783 no 97 0.00992361347175967 129 1868434 SGTC_219 mitoxanthrone 164.414 µM 2.32518124383944 0.017086410228176 no 98 0.0100311354184286 167 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA.  YMR168C CEP3 SGTC_2046 4110841 106 µM 2.32131387657223 0.0172363733359147 no 99 0.0101349549227577 131 44119630 YMR134W ERG29 SGTC_637 1181-0519 7.26 µM 2.30927979213968 0.0177102270925733 no 100 0.0104640301356372 259 6252091 YGR060W ERG25 SGTC_2050 5263056 171 µM 2.30885746784144 0.0177270564476759 no 101 0.0104757459083394 186 763468 YGL055W OLE1 SGTC_1762 st045503 25.4615 µM 2.28289180314088 0.0187883110968134 no 102 0.0112183712210128 156 4645554 SGTC_919 tnp00227 403.569 nM 2.27843657526197 0.0189757323974279 no 103 0.0113502896618886 179 1269246 A methoxyflavone. YNL221C POP1 SGTC_1391 3442-0225 151 µM 2.25589530813288 0.0199485453502642 no 104 0.0120385942200431 135 5227075 SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM 2.24883342518907 0.0202618889904893 no 105 0.0122615479612023 222 368090 SGTC_490 phenamil 164 µM 2.23820683821255 0.0207412608952407 no 106 0.0126037849678222 81 4755 Irreversibly blocks amiloride-sensitive Na+ channels. SGTC_3251 9135047 49.47 µM 2.23437691888948 0.0209163693229281 no 107 0.0127291415390868 92 17682963 SGTC_3257 9139206 32.98 µM 2.23152941606987 0.0210473701161549 no 108 0.0128230406178106 84 4910041 SGTC_184 1494-0393 24.714 µM 2.22385761412919 0.0214037746598708 no 109 0.0130790128028157 219 3090647 SGTC_1609 st001574 46.4 µM 2.21239457402641 0.0219458062027241 no 110 0.0134697067380651 158 3960012 SGTC_202 3594-0513 34.79 µM 2.2096372552705 0.0220779019254158 no 111 0.0135651737757243 102 708429 SGTC_1768 st044301 37.178 µM 2.20505470294938 0.0222989241035182 no 112 0.0137251280704685 168 3931349 SGTC_451 chloral hydrate 100 µM 2.20478223301754 0.0223121242520801 no 113 0.0137346896890429 252 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1 SGTC_126 0417-1624 672.48 µM 2.20275024189898 0.022410774659026 no 114 0.0138061784861427 217 41912 YDL195W SEC31 SGTC_1190 1486-1332 13 µM 2.19566322875187 0.0227577231482214 no 115 0.0140580284722775 169 4150046 SGTC_1789 tunicamycin 25 nM 2.1880051885498 0.0231377037705934 no 116 0.0143346121881465 191 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_816 0325-0417 81.3 µM 2.18790767249019 0.0231425766091365 no 117 0.0143381641563586 145 68101 SGTC_1515 3460-0031 42.1 µM 2.186666486962 0.0232046736784413 no 118 0.0143834399076735 134 2876596 SGTC_2446 5162541 200 µM 2.18183395931391 0.0234477850615824 no 119 0.0145608946404603 150 1549321 SGTC_2083 5306046 65.942 µM 2.18114003721543 0.0234828697378372 no 120 0.0145865301500726 208 539837 SGTC_2999 9069765 71.4286 µM 2.178669784131 0.0236081243011244 no 121 0.0146781039861627 184 2097066 SGTC_3354 9151612 71.43 µM 2.17509785522286 0.0237902328318732 no 122 0.0148113920809097 162 27261949 SGTC_377 3970-0964 33.1 µM 2.16494871237533 0.0243141252014842 no 123 0.0151958065786023 272 16481235 SGTC_250 brefeldin a 552.239 µM 2.14764852786169 0.0252294729539212 no 124 0.0158708436131073 127 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.  SGTC_3216 9129716 49.47 µM 2.13587568481034 0.025868741804231 no 125 0.016344773998177 173 8056934 SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM 2.13408402190602 0.0259672078791672 no 126 0.0164179517852765 168 688798 SGTC_1955 wogonin 32.4 µM 2.12548529234062 0.0264441497350071 no 127 0.0167730700108235 159 5281703 A flavanone. SGTC_329 k048-0121 21.3 µM 2.11747126376751 0.026895229525923 no 128 0.0171099358167646 178 6832902 SGTC_1333 1482-0047 286 µM 2.11629502364077 0.0269619731937809 no 129 0.0171598618633608 212 3811116 SGTC_3047 9092122 49.47 µM 2.10193562896099 0.0277879762952535 no 130 0.0177794574905547 190 17173831 SGTC_1174 0739-0097 51.1 µM 2.09885161032726 0.027968103415589 no 131 0.0179149918138692 212 728447 SGTC_17 0960-0276 49.807 µM 2.0972958615313 0.0280593378388551 no 132 0.0179836964965844 231 6821114 SGTC_576 1073-0113 22.7 µM 2.09197479516883 0.0283732586807571 no 133 0.0182203852236758 317 5439563 SGTC_2957 9076800 11.52 µM 2.0868106862749 0.0286807087788967 no 134 0.0184526253892993 191 16459615 SGTC_125 0133-0007 11.75 µM 2.08286560245977 0.0289174453869523 no 135 0.0186317378842495 170 26541 SGTC_1704 st028805 70.8 µM 2.08196435907032 0.0289717544983265 no 136 0.0186728626641601 158 2876101 SGTC_59 0330-0160 1.33 µM 2.08025478946131 0.0290750064197108 no 137 0.0187510846118812 381 4293482 SGTC_2465 5809242 33.21 µM 2.0789460427136 0.0291542565318196 no 138 0.0188111550616305 104 2731748 SGTC_2208 7283366 200 µM 2.07425417695821 0.029439844953676 no 139 0.0190278555353951 174 898663 SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM 2.07297048977235 0.0295183849299672 no 140 0.0190875130112092 210 5355888 SGTC_1152 3909-8331 15.9 µM 2.07099949241494 0.0296393151743154 no 141 0.0191794217453628 181 16001939 SGTC_847 0342-0274 5.54 µM 2.06738016709692 0.0298624489901796 no 142 0.0193491727854066 188 18097 SGTC_1547 harmine 94.2 µM 2.06694137479364 0.0298895952880013 no 143 0.0193698392197413 265 5280953 A monoamine oxidase inhibitor YHR072W ERG7 SGTC_2776 terbinafine 19.92 µM 2.06487672941598 0.0300176013909795 no 144 0.0194673327190625 220 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_2674 ligustilide 100 µM 2.06058507349676 0.0302851348707099 no 145 0.0196713209929719 143 5319022 A signalling regulator. SGTC_1485 3909-9022 254 µM 2.05654073922285 0.0305390564032495 no 146 0.0198652118270201 184 714516 SGTC_931 2812-0076 566 µM 2.05618231610788 0.030561644638133 no 147 0.0198824730802467 208 3450959 SGTC_1683 st010134 710 nM 2.05331367878334 0.0307429284764576 no 148 0.0200210825350952 228 3818134 SGTC_3182 9108849 49.47 µM 2.05314731086038 0.0307534693715981 no 149 0.0200291463396737 216 17133045 SGTC_1104 tacrolimus 29.8 µM 2.04868201556573 0.0310375055795701 no 150 0.020246609461026 219 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41 SGTC_425 3825-7017 13.1 µM 2.04817021613471 0.0310701992134128 no 151 0.0202716618586788 235 3397440 SGTC_747 3448-8087 38.7 µM 2.04809672655435 0.0310748960500595 no 152 0.0202752613039477 236 5168703 SGTC_2226 7298446 200 µM 2.04726572626855 0.0311280474972984 no 153 0.0203160005740625 127 3283010 SGTC_772 k072-0172 35.3 µM 2.04530532899079 0.031253734126331 no 154 0.0204123828351733 190 5861980 SGTC_678 1218-2179 85.9 µM 2.04460557824146 0.0312986986559208 no 155 0.020446879557942 122 6820081 YOR116C RPO31 SGTC_159 3970-0959 50 µM 2.04099306397408 0.0315316831134461 no 156 0.0206257582612273 408 6615653 SGTC_511 blebbistatin 171 µM 2.03788298755559 0.0317334101209673 no 157 0.0207808181755637 203 3476986 A myosin inhibitor. SGTC_2808 7946468 45.46 µM 2.0322394821033 0.0321021841366171 no 158 0.0210647088476015 252 2970879 SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM 2.02971791703852 0.0322680953006294 no 159 0.0211926103046727 157 616764 SGTC_2034 5197015 53.07 µM 2.02436872517191 0.0326223990574568 no 160 0.021466113590573 205 780676 SGTC_2235 salicylic acid 500 µM 2.02211664487846 0.0327725223129512 no 161 0.0215821514233074 141 338 A COX inhibitor and kinase inhibitor. SGTC_646 4092-0839 27.3 µM 2.01770049642357 0.0330685555290434 no 162 0.0218112315539046 201 877796 SGTC_157 1348-1695 65.819 µM 2.01464101152413 0.0332749350493957 no 163 0.0219711385312951 307 5380510 SGTC_1777 st045864 34.765 µM 2.01264946259893 0.0334098454057468 no 164 0.0220757597483098 198 4691462 SGTC_1465 k213-0056 144 µM 2.00891729144687 0.03366388077559 no 165 0.0222729529090993 220 24048857 YMR208W ERG12 SGTC_507 nimesulide 162 µM 2.00231658993284 0.0341170574866905 no 166 0.02262534643053 217 4495 A COX2 inhibitor. SGTC_1353 1498-1206 8.11 µM 1.99950006082347 0.034311949539227 no 167 0.0227771376453492 292 6756808 SGTC_205 1486-1330 71.903 µM 1.99486411311827 0.0346347296284637 no 168 0.0230288512428141 153 4118834 SGTC_2328 6201408 200 µM 1.97938207259956 0.0357307905160903 no 169 0.023886502688909 215 2890418 SGTC_256 clotrimazole 625 nM 1.97785717066876 0.0358402678883898 no 170 0.0239724108924049 255 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C SGTC_1517 deoxycholic acid methyl ester 49.2 µM 1.97685538843185 0.0359123383666555 no 171 0.0240289893661268 192 229346 A bile salt which induces apoptosis. SGTC_253 dyclonine 31.25 µM 1.96603839340568 0.0366981248874049 no 172 0.0246470879142286 252 3180 An oral anasthetic. SGTC_2261 9010538 184.68 µM 1.96537144059363 0.0367470315209873 no 173 0.0246856312381923 189 6457250 SGTC_543 3844-1095 191 µM 1.95520251302258 0.0374993274847307 no 174 0.0252795860442902 275 4230703 SGTC_1686 st019653 115.5 µM 1.95196105686265 0.0377417568688268 no 175 0.025471414160788 192 97252 SGTC_2872 9044037 25.97 µM 1.9486961060495 0.0379872351141319 no 176 0.0256658635464079 152 6465195 SGTC_2995 9067767 71.4286 µM 1.94712558298965 0.0381057794403153 no 177 0.0257598402978765 202 11673567 SGTC_3323 9138564 53.9225 µM 1.94701236700703 0.038114336719328 no 178 0.0257666260152471 258 43912313 YNL103W MET4 SGTC_1034 k072-0165 12.7 µM 1.94233337318694 0.0384693654126856 no 179 0.0260483776876217 271 5835461 SGTC_529 4076-0302 30.3 µM 1.93579929769915 0.0389696580077308 no 180 0.0264461434897052 232 5816522 SGTC_2537 larixol 68.93 µM 1.93553513841203 0.0389899947109821 no 181 0.0264623305142416 265 6708759 SGTC_2266 7929956 200 µM 1.93270213610261 0.0392086414348932 no 182 0.0266364509547999 250 2967153 SGTC_1014 4130-3005 69.3 µM 1.92897515955394 0.0394978025687146 no 183 0.0268669730489407 268 743608 SGTC_721 1187-1332 279 µM 1.92777266107696 0.0395914688812838 no 184 0.0269417048259733 155 25730 SGTC_2231 micatex 6.853 µM 1.92769411367968 0.0395975934601757 no 185 0.0269465923492638 179 20737 An antifungal of unknown mechanism. SGTC_1726 st035556 14.5795 µM 1.92313602050812 0.0399543236148093 no 186 0.027231484836405 288 5919439 SGTC_106 0092-0003 11.579 µM 1.91507114572913 0.0405919012731551 no 187 0.0277417155078515 182 1072148 SGTC_1641 st009299 47.1 µM 1.9130756234703 0.0407509274601246 no 188 0.0278691859519684 163 4046054 SGTC_965 1291-5240 308 µM 1.90945966138497 0.0410403767416756 no 189 0.0281014103524922 272 2834598 SGTC_247 mechlorethamine 29.705 µM 1.90695353167127 0.0412419631034385 no 190 0.0282633025790775 198 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links. SGTC_1021 4476-0760 85.3 µM 1.90472589325246 0.0414218215465658 no 191 0.0284078556632408 271 746768 SGTC_2185 6113692 200 µM 1.90213806617379 0.0416315590209011 no 192 0.0285765535368363 222 874150 SGTC_2228 7354201 200 µM 1.89348696368588 0.0423389635383155 no 193 0.0291465701213265 187 753451 SGTC_2751 anetholtrithion 17.25 µM 1.88652802457814 0.04291502916469 no 194 0.0296119177931254 248 2194 A chloretic substance that stimulates the liver to produce bile. SGTC_91 0417-1751 58.384 µM 1.87963103808719 0.0434921993079191 no 195 0.0300791900631259 338 6795624 SGTC_1073 triclabendazole 3.09 µM 1.87205597351949 0.0441333171245448 no 196 0.0305994300477147 309 50248 An antihelmetic and likely tubulin inhibitor. SGTC_2264 7948757 110.76 µM 1.86956672028352 0.0443456514769722 no 197 0.0307720051649006 259 2971411 SGTC_2305 7443522 69.23 µM 1.86715364641542 0.0445522728165675 no 198 0.0309400673165797 261 5415886 SGTC_1401 3807-4679 7.6 µM 1.86688658724039 0.0445751875544365 no 199 0.0309587136528289 224 3291456 SGTC_2385 9074692 200 µM 1.86668798967084 0.0445922341690587 no 200 0.0309725859604343 301 17046906 SGTC_263 alizarin 107.927 µM 1.86605886958547 0.0446462693345199 no 201 0.0310165648075769 354 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. SGTC_1811 st050069 61.5 µM 1.86239533344028 0.0449619792519426 no 202 0.0312736932222062 192 3877702 SGTC_168 3970-0862 530.542 µM 1.85046541735163 0.0460025264325362 no 203 0.0321232489891669 498 3135186 SGTC_886 0866-0150 153 µM 1.85029836497697 0.0460172332117741 no 204 0.0321352790944535 296 271463 SGTC_2349 9023730 187.07 µM 1.83771506346145 0.0471359303081771 no 205 0.0330522015076703 287 4126287 SGTC_2297 7971671 152.32 µM 1.83550260253582 0.0473348606877075 no 206 0.0332156269153482 278 909016 SGTC_1018 4259-0013 28.1 µM 1.83132729140516 0.0477121105916285 no 207 0.0335258532537735 257 6801262 SGTC_2 0422-0095 29 µM 1.82727093292162 0.0480809148883466 no 208 0.0338295216728485 181 6790840 SGTC_497 capsazepine 133 µM 1.82624969833641 0.0481741241574769 no 209 0.0339063291884684 246 2733484 A calcium channel blocker. SGTC_2556 citropten 84.59 µM 1.82537392910818 0.0482541717379394 no 210 0.0339723103829899 311 2775 A potential DNA crosslinker. SGTC_3124 9127567 49.47 µM 1.81859234205119 0.0488776343117987 no 211 0.0344868235111652 243 17592030 SGTC_2256 7954252 200 µM 1.81603776757842 0.0491141506068442 no 212 0.0346822894289382 208 2972920 SGTC_1608 st001473 40.5 µM 1.81387048258787 0.0493155255238611 no 213 0.0348488340361052 295 7292267 SGTC_1470 k295-0292 231 µM 1.81182790508638 0.0495059160569517 no 214 0.0350063959578454 288 5045612 SGTC_1861 st057647 17.4 µM 1.80928669525625 0.049743603033904 no 215 0.0352032374445563 274 688668 SGTC_107 0358-0022 2.6945 µM 1.80476336091466 0.0501689358635206 no 216 0.0355558600430904 175 521106 YGL093W | YPR107C SPC105 | YTH1 SGTC_290 2043-6722 48.1 µM 1.80221773238845 0.0504095753029759 no 217 0.0357555779414588 260 773758 YLR208W SEC13 SGTC_2284 7945075 39.21 µM 1.80187402360378 0.0504421366097335 no 218 0.035782614001913 318 1245402 SGTC_1042 0350-0096 82 µM 1.80138136411165 0.0504888380084233 no 219 0.0358213957050183 287 3122515 SGTC_2934 9036370 36.88 µM 1.80034249751412 0.0505874297297558 no 220 0.0359032872138753 323 6462800 SGTC_3259 9138485 49.47 µM 1.80024572863318 0.0505966212046113 no 221 0.0359109230884911 305 17646153 SGTC_2214 7179297 48.276 µM 1.79645616197184 0.0509576158569188 no 222 0.0362109993647435 209 769744 SGTC_1146 3579-1023 7 µM 1.79253377343759 0.0513334193753565 no 223 0.0365237520898504 321 X1146 SGTC_1310 1188-0297 994 nM 1.79178425076043 0.0514054813091465 no 224 0.0365837662855794 306 1588352 SGTC_1493 4348-0038 111 µM 1.79094626222734 0.0514861439238937 no 225 0.0366509594288102 316 800424 SGTC_2883 9059145 45.46 µM 1.79086245229316 0.0514942167857668 no 226 0.0366576851812472 236 16476510 SGTC_2534 helenine 20.12 µM 1.78922690001123 0.0516519604102489 no 227 0.0367891405712552 232 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58 SGTC_1427 4048-4900 550 nM 1.78920747058164 0.0516538366209919 no 228 0.0367907045003485 277 24132586 SGTC_1217 1183-1422 255 µM 1.78425974871311 0.0521333816899901 no 229 0.0371907337738466 279 2849664 SGTC_344 k064-0035 6.43 µM 1.78331250781234 0.0522255926034359 no 230 0.0372677232328626 285 5088750 SGTC_857 0438-0306 1.35 µM 1.78156895062594 0.0523956609881177 no 231 0.0374097757646452 280 4686136 SGTC_1887 st057648 70.8 µM 1.7798995550982 0.0525589073136761 no 232 0.0375462002662327 277 688672 SGTC_2840 9008771 71.43 µM 1.76978969145698 0.0535561690816918 no 233 0.0383810908921172 220 2992978 SGTC_589 1227-0070 34.1 µM 1.7622255870822 0.0543120690238318 no 234 0.0390155953135561 287 2841384 SGTC_2135 5326629 150.42 µM 1.75979522256504 0.0545567251794278 no 235 0.0392212667019467 294 5020077 SGTC_2653 dihydrofissinolide 100 µM 1.75800960799742 0.0547370314157251 no 236 0.0393729372652784 224 6857746 SGTC_557 1315-0110 16.2 µM 1.75384019097294 0.0551598814604632 no 237 0.0397289470986141 310 6833801 SGTC_560 2332-1943 155 µM 1.74789291717351 0.0557674970875741 no 238 0.0402412857702259 267 21177716 SGTC_3118 9124250 49.47 µM 1.74739284888399 0.0558188273798775 no 239 0.0402846085389353 270 1504786 SGTC_2578 7,8-dihydroxyflavone 64.44 µM 1.73942107389519 0.0566421464717668 no 240 0.0409803620217778 306 1880 Intensifies effect of antibiotics on Staphylococcus aureus. SGTC_2268 7933382 153.85 µM 1.73770257789512 0.0568208788504749 no 241 0.0411316171305222 381 935025 YOR257W CDC31 SGTC_3014 9081533 49.47 µM 1.73256584887595 0.0573577739596177 no 242 0.0415864318319657 298 21367265 SGTC_1926 methyl fluorone black 53.6 µM 1.73050127728154 0.0575746859890065 no 243 0.041770376612208 321 72721 Reacts with homocysteine. SGTC_1266 0828-0227 32.9 µM 1.72003085434349 0.0586846987510751 no 244 0.0427134166076691 301 3913820 SGTC_2624 nerol 100 µM 1.71976888095865 0.0587126855347846 no 245 0.0427372306783019 280 637566 A natural product oil. SGTC_2834 9001755 58.44 µM 1.70790647690469 0.0599909656205995 no 246 0.0438268486018514 307 2989575 SGTC_2616 abietic acid 100 µM 1.70512927652333 0.0602933596870759 no 247 0.044085158260293 337 6708678 Abietic acid is an inhibitor of 5α-reductase. SGTC_3253 9135987 49.47 µM 1.70007373532423 0.0608468909432589 no 248 0.0445585284539519 260 4182430 SGTC_2151 5563267 85.4165 µM 1.69914047797255 0.0609495064107413 no 249 0.0446463590902117 335 5310824 SGTC_3226 9131256 49.47 µM 1.69651404861843 0.0612390192818076 no 250 0.044894285964909 168 17178073 SGTC_2594 a-mangostin 100 µM 1.69607036839735 0.0612880323378934 no 251 0.0449362772430754 366 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis. SGTC_884 0851-0618 334 µM 1.69031195084036 0.0619269447059146 no 252 0.0454841449685378 359 9642473 SGTC_3035 9091303 49.47 µM 1.68946794554808 0.062021024623323 no 253 0.0455648948317728 277 25237002 SGTC_810 3825-7150 143 µM 1.68665246080231 0.0623356688998733 no 254 0.0458350990885685 320 22330411 YGL099W LSG1 SGTC_746 1095-0025 46.6 µM 1.68472221408782 0.0625521017770099 no 255 0.0460210892836938 333 6749286 SGTC_2662 daunorubicin 22.37 µM 1.68269198359645 0.0627803771918999 no 256 0.0462173671995037 288 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_48 0382-0018 55 µM 1.68103649495005 0.0629669973665836 no 257 0.0463779130403915 282 762596 SGTC_1582 3',3',6'-trihydroxyflavone 74 µM 1.68005613007468 0.0630777156445161 no 258 0.0464731976601289 285 688803 SGTC_1911 st060208 74.3 µM 1.67599796984807 0.0635376407221879 no 259 0.0468692951336832 360 688783 SGTC_2468 5987765 72.9 µM 1.67073977759349 0.0641374458371467 no 260 0.0473865441504195 346 26772094 SGTC_131 0141-0277 33.849 µM 1.6695741750175 0.0642710009464181 no 261 0.0475018217201753 363 1547771 SGTC_3008 9078912 71.4286 µM 1.66386497790978 0.0649282868768684 no 262 0.0480697076037517 308 16648731 SGTC_553 k007-0256 45.7 µM 1.66233498469777 0.0651053148586103 no 263 0.0482228134431346 353 6287000 SGTC_1977 st070720 65.3 µM 1.65944665896583 0.0654405295613861 no 264 0.0485129103993178 302 682188 SGTC_2105 5350118 200 µM 1.65926042250275 0.0654621897373585 no 265 0.048531663358367 328 2133313 SGTC_2073 5212005 126 µM 1.65428300248424 0.0660431496000777 no 266 0.0490350124666209 235 691789 SGTC_1125 tnp00248 1.32998 µM 1.6515902114581 0.0663591105002698 no 267 0.049309058409673 456 24207736 SGTC_94 0334-0113 514.748 µM 1.65118305728349 0.0664069859784207 no 268 0.0493506008054906 347 6795178 SGTC_2093 5331342 194.4 µM 1.64914078137506 0.0666475318753978 no 269 0.0495593982657854 347 33839 SGTC_3174 9107204 49.47 µM 1.6480669717116 0.066774278881715 no 270 0.0496694644892032 350 3938802 SGTC_2156 5649887 115 µM 1.64592640320257 0.0670274970355263 no 271 0.0498894561149133 389 54680440 YKL052C | YBR257W ASK1 | POP4 SGTC_1520 flindersine 88 µM 1.6448227094249 0.0671583481452456 no 272 0.0500031887799834 354 68230 Flindersine is a natural alkaloid of the quinoline subtype. SGTC_2507 purpurin 79.67 µM 1.64463373232908 0.0671807725784205 no 273 0.0500226830744365 375 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1 SGTC_352 k048-0007 5.11 µM 1.64373648198368 0.067287321264257 no 274 0.0501153233608605 408 6811911 SGTC_3121 9125696 49.47 µM 1.63503805177026 0.0683270448950088 no 275 0.0510205355096737 273 1235365 SGTC_2471 5466956 24.79 µM 1.62901076417328 0.0690547277799099 no 276 0.0516553701278328 306 724419 SGTC_1090 efavirenz 20.7 µM 1.62616989113926 0.0693997746772055 no 277 0.0519567596658339 338 64139 A non-nucleoside reverse transcriptase inhibitor. SGTC_1743 st037606 46.3785 µM 1.62393139711543 0.0696725919957024 no 278 0.0521952253979937 376 590142 YLR208W | YDL195W SEC13 | SEC31 SGTC_2860 9025725 38.96 µM 1.61999708398957 0.0701540876982145 no 279 0.0526164516522275 317 40546248 SGTC_2868 9035608 32.47 µM 1.6136971216305 0.0709304255022069 no 280 0.053296569301545 389 6462614 SGTC_936 3005-4620 401 µM 1.61234978485793 0.0710973097903321 no 281 0.0534429227271086 393 777207 SGTC_1728 st035614 33.7865 µM 1.61116829776169 0.0712438995341638 no 282 0.053571522768178 442 15945546 SGTC_1064 honokiol 6.76 µM 1.60759100119848 0.0716891577290505 no 283 0.0539623921845609 378 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis. SGTC_1051 3253-3903 78 µM 1.6067596989668 0.0717929331139831 no 284 0.0540535460251003 400 5509239 SGTC_3151 9099821 49.47 µM 1.59733821911846 0.0729771271733471 no 285 0.0550951679065529 326 17174189 SGTC_141 0443-0274 32.331 µM 1.59339671335324 0.073476951360587 no 286 0.0555356112833344 506 1627241 SGTC_1553 gossypol 38.6 µM 1.59054158297981 0.0738406437590379 no 287 0.0558563901155953 238 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_1902 st060212 70.5 µM 1.58900679218402 0.0740367163016452 no 288 0.0560294296332741 388 688944 SGTC_1548 st061468 90.8 µM 1.58774721060148 0.0741979272918053 no 289 0.0561717564138854 350 390799 SGTC_1770 st043884 66.3 µM 1.58740434280601 0.0742418565528409 no 290 0.0562105481791163 373 670149 SGTC_144 4161-2749 112.381 µM 1.58665177091875 0.0743383479870256 no 291 0.0562957675698997 319 797501 YMR168C CEP3 SGTC_1279 0874-0590 65.2 µM 1.58196505102459 0.0749414148458056 no 292 0.0568287745458258 373 3523074 SGTC_703 3875-0075 71.8 µM 1.57618168880544 0.0756907280624683 no 293 0.0574919686313687 344 2850814 SGTC_2432 5630864 12.22 µM 1.57450598799006 0.0759089007967584 no 294 0.0576852591412185 381 5714970 SGTC_3294 9122953 26.2835 µM 1.57413234790365 0.0759576131827543 no 295 0.0577284277702822 385 16459826 SGTC_2544 sphondin 68.51 µM 1.57128248883602 0.0763299398253229 no 296 0.0580585234251155 355 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31 SGTC_2897 9048598 12.99 µM 1.5710728122195 0.0763573882785017 no 297 0.0580828684688783 354 6467404 SGTC_2646 retinol 96.75 µM 1.57064228160317 0.0764137719416914 no 298 0.0581328814803594 369 445354 A vitamin A analog and teratogen. SGTC_2232 chlorophetanol 41.5365 µM 1.56695026008774 0.0768985921406142 no 299 0.0585631591958217 525 15907 An antifungal of unknown mechanism. YFR051C RET2 SGTC_2154 5570129 200 µM 1.56429989653495 0.0772480656416557 no 300 0.058873578211387 422 673366 SGTC_2980 9014342 25.29 µM 1.56021230296793 0.077789414079157 no 301 0.0593548596041061 379 2996599 SGTC_3340 9146634 11.102 µM 1.55436260998723 0.0785691320295287 no 302 0.0600489733489933 377 4907387 SGTC_1300 1094-0077 113 µM 1.55394516875983 0.0786249992957692 no 303 0.0600987481117107 355 5532636 SGTC_1386 3228-0095 33.8 µM 1.55374395173982 0.078651939454756 no 304 0.0601227523170537 364 870181 SGTC_1514 1189-1591 158 µM 1.55362887196659 0.078667350179324 no 305 0.0601364841444009 468 767698 YMR146C TIF34 SGTC_2498 4'-Methoxychalcone 54.63 µM 1.55342550157568 0.078694589796461 no 306 0.0601607572024142 377 641818 YHR062C RPP1 SGTC_342 k048-0088 23.3 µM 1.55304818170022 0.0787451472995522 no 307 0.0602058121334836 393 6820570 SGTC_1965 Pectolinarigenin 58.4 µM 1.55241829799468 0.0788296009387057 no 308 0.0602810839995986 376 5320438 An anti-inflammatory. SGTC_150 3970-0969 77.2 µM 1.54965344894245 0.0792011186395323 no 309 0.0606123584192516 486 6615640 SGTC_1804 st050076 49.1 µM 1.54824703188225 0.0793906093769856 no 310 0.0607814159060653 390 3895976 SGTC_2234 tolnaftate 200 µM 1.54114815841724 0.0803523021370696 no 311 0.0616403656633819 290 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7 SGTC_3138 9097216 49.47 µM 1.53970277968364 0.0805491834445973 no 312 0.0618164094829791 380 25237486 SGTC_207 4185-0010 4.486 µM 1.53753877192901 0.0808446332172443 no 313 0.0620807140262151 488 3761753 SGTC_3164 9100705 49.47 µM 1.53634415939767 0.081008082560625 no 314 0.0622269971844794 319 17174235 SGTC_2388 9080168 200 µM 1.5344378270026 0.0812694272813516 no 315 0.0624609888235845 350 15943073 SGTC_2567 aureobasidin a 60 nM 1.5332926943831 0.0814267224051487 no 316 0.0626018769232494 455 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1 SGTC_149 3970-0822 46.1 µM 1.52945588583034 0.0819554190949474 no 317 0.0630757335864373 565 3114250 YBL034C STU1 SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM 1.52712948902641 0.0822772444571614 no 318 0.0633644076986037 390 6708514 SGTC_371 0195-0006 7.36 µM 1.52581504903168 0.0824594996511235 no 319 0.0635279658777627 338 3928593 SGTC_530 4358-1714 28 µM 1.52535279968616 0.0825236655551597 no 320 0.0635855624339727 479 1564641 SGTC_1410 3909-8106 77.9 µM 1.52478014149518 0.0826032096842505 no 321 0.0636569723420593 364 1039210 SGTC_1425 4048-4433 7.33 µM 1.5212689108008 0.0830921934827668 no 322 0.0640961843240538 463 23734946 SGTC_684 1140-0066 328 µM 1.51973991941525 0.0833058041909223 no 323 0.0642881772117866 455 6813534 SGTC_751 0833-0568 350 µM 1.5180901287702 0.0835367541481012 no 324 0.0644958396497307 394 6954252 SGTC_2153 5569715 200 µM 1.51627448682586 0.0837914769574609 no 325 0.0647249800553322 383 2054701 SGTC_566 0958-0068 16.5 µM 1.51608998633529 0.0838173938007298 no 326 0.0647483000073463 346 6815365 SGTC_1417 3966-0327 90.4 µM 1.51588789683855 0.0838457882860686 no 327 0.0647738506095491 447 651118 SGTC_1392 3455-1037 33.9 µM 1.51533967292516 0.0839228525991875 no 328 0.0648432031456131 412 981132 SGTC_2383 9036125 200 µM 1.51511808255041 0.08395401684175 no 329 0.0648712515771067 346 79580 SGTC_526 4469-0568 170 µM 1.51340924934548 0.0841946373545678 no 330 0.0650878685039421 415 2901964 SGTC_1935 st074532 41.6 µM 1.51285961338011 0.0842721414233569 no 331 0.0651576612274973 497 2829742 SGTC_2039 Aminomethylbenzodioxan 200 µM 1.51141243196713 0.0844764642944178 no 332 0.0653417019395141 344 15053 SGTC_1405 3909-7894 12 µM 1.50837006415413 0.0849072179859171 no 333 0.0657299201372896 408 7104060 SGTC_84 0443-0269 128.823 µM 1.50672480422382 0.0851408470849189 no 334 0.065940605456105 430 6150058 SGTC_2089 5281248 129.67 µM 1.50643209451962 0.0851824626810092 no 335 0.0659781434468432 425 2737878 SGTC_518 1021-0119 62.6 µM 1.5049359685042 0.0853954104016688 no 336 0.0661702699015476 434 1097762 SGTC_1764 st044502 93.5 µM 1.50315217770979 0.0856498230663972 no 337 0.0663999031319674 430 8407 SGTC_1331 1472-0049 76.2 µM 1.50240507100714 0.0857565474063741 no 338 0.0664962637619601 416 24051409 SGTC_376 3970-0862 59.1 µM 1.49984729285482 0.0861226803498486 no 339 0.0668269817964501 435 3135186 SGTC_3093 9117344 49.47 µM 1.4927767650946 0.087140873522877 no 340 0.0677478156365136 414 24824913 SGTC_2796 7949634 45.45 µM 1.48850583476538 0.0877602496738598 no 341 0.0683087722760876 422 2971588 SGTC_2728 chlorpromazine 9.18 µM 1.48707679351327 0.0879682227259075 no 342 0.0684972649457069 311 2726 A thorazine and dopamine antagonist. SGTC_1799 st045822 46.1415 µM 1.4834738648783 0.0884941997835921 no 343 0.0689742776006408 403 3674992 SGTC_2917 7979103 53.79 µM 1.48322381402488 0.088530790463439 no 344 0.0690074780659452 492 2980565 SGTC_2019 4016004 108 µM 1.48322371604392 0.0885308048034915 no 345 0.0690074910777668 378 45595336 SGTC_1439 4092-1168 46 µM 1.48203962418947 0.0887042295510977 no 346 0.0691648760087599 415 2886240 SGTC_2230 bromochlorosalicylanilide 954.5 nM 1.47926547098916 0.0891115288048612 no 347 0.069534688720266 344 77254 SGTC_1706 st031321 9.9705 µM 1.47824660373185 0.0892614671277406 no 348 0.0696708920126029 411 6103185 SGTC_2740 felodipine 17.08 µM 1.47768511116679 0.0893441775597743 no 349 0.069746040687055 338 3333 L-type calcium channel blocker SGTC_2149 5554786 194.827 µM 1.47547132330601 0.0896708342384689 no 350 0.0700429362341039 481 745063 YPR165W RHO1 SGTC_2942 9052777 62.25 µM 1.47534713972327 0.089689184482864 no 351 0.0700596195011542 484 6469503 SGTC_3224 9130643 49.47 µM 1.47520567097397 0.0897100923073792 no 352 0.0700786286441049 431 17644395 SGTC_1633 st005664 67.9 µM 1.47147395790354 0.0902629155616259 no 353 0.0705814926246442 455 2063822 SGTC_3069 9117009 49.47 µM 1.46991914630349 0.0904939936448552 no 354 0.0707918266932267 305 41904981 SGTC_2813 7971799 71.43 µM 1.46945411791605 0.0905631920092313 no 355 0.0708548289489526 415 2234054 SGTC_712 r015-0009 80.6 µM 1.4689391978244 0.0906398603083082 no 356 0.0709246408010813 386 6813872 YLR060W FRS1 SGTC_2503 beta-caryophyllene alcohol 24.72 µM 1.46888074117088 0.0906485671732125 no 357 0.0709325695775467 358 61125 An anti-inflammatory. SGTC_1982 st072467 71.9 µM 1.46852189473594 0.0907020293952565 no 358 0.0709812566835606 504 3163533 SGTC_1747 st037496 66.6 µM 1.46674770273777 0.0909666987466776 no 359 0.071222350479582 476 723305 SGTC_1225 1216-0074 20.6 µM 1.46323922936304 0.0914917696124209 no 360 0.0717009649513671 431 4241466 SGTC_1474 0330-0125 5.35 µM 1.44742625448734 0.0938862020918031 no 361 0.0738887884589613 434 X1474 SGTC_1584 6-fluoro-dl-tryptophan 90 µM 1.44651587588434 0.0940254483682073 no 362 0.0740162812003965 460 94937 An inhibitor of serotonin biosynthesis. SGTC_828 2074-0507 139 µM 1.44608118940264 0.0940919892405156 no 363 0.0740772155343727 478 X828 SGTC_336 4111-0029 111 µM 1.44409969755041 0.0943957519471409 no 364 0.0743554665807244 374 3131175 SGTC_3273 9137859 49.47 µM 1.44342006731271 0.0945001056387326 no 365 0.0744510872565311 388 2377234 SGTC_143 4032-1194 15.74 µM 1.44168232736197 0.0947673132996275 no 366 0.0746960057054011 550 1806963 SGTC_1363 1636-0063 10.4 µM 1.4404523964101 0.0949567727444538 no 367 0.0748697243966592 478 6072185 SGTC_505 gw-5074 63.9 µM 1.4394707370964 0.0951081883666435 no 368 0.0750085975804892 463 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases. SGTC_851 0394-0702 453 µM 1.43523327051293 0.095763835347158 no 369 0.0756103178920779 488 762646 SGTC_662 k832-1615 104 µM 1.43370172970814 0.0960016209999727 no 370 0.0758286991959733 451 5878478 SGTC_1478 0453-0656 35.7 µM 1.43103784708136 0.096416246892964 no 371 0.0762096842492357 462 5258496 SGTC_1481 3346-2004 36 µM 1.42864009329084 0.0967905744937409 no 372 0.0765538521542043 465 2770522 SGTC_5 0352-0601 109.883 µM 1.42772911732031 0.0969330717699743 no 373 0.0766849209559135 407 762456 SGTC_1027 k015-0025 8.67 µM 1.42758942388014 0.096954936600882 no 374 0.0767050347585905 482 3598955 SGTC_2839 9003951 25.97 µM 1.42088184275294 0.0980090729202301 no 375 0.0776755562066647 426 2990634 SGTC_2733 amorolfine 100 µM 1.41874417953806 0.0983467778047217 no 376 0.0779868059809653 323 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_3292 9120825 59.784 µM 1.41866204275189 0.0983597706328051 no 377 0.077998784179274 452 24824900 SGTC_3165 9101544 49.47 µM 1.41257115114039 0.0993267659251856 no 378 0.0788909282196284 486 5002184 SGTC_1707 st032323 6.317 µM 1.41198099164092 0.09942082822057 no 379 0.078977779086054 500 3132057 YMR211W DML1 SGTC_1701 st028638 40.4 µM 1.41177271532496 0.0994540397833296 no 380 0.0790084473687663 464 3490878 SGTC_1303 1160-0052 261 µM 1.41153955695626 0.0994912286363095 no 381 0.0790427901849984 464 3562476 SGTC_2866 9034245 58.44 µM 1.4113029960741 0.0995289705777845 no 382 0.079077645724032 402 6462273 SGTC_714 4296-0578 26.1 µM 1.41043502942986 0.0996675393410436 no 383 0.0792056340553191 349 1589775 SGTC_1372 2752-0194 270 µM 1.40855318418706 0.0999684553636932 no 384 0.0794836651282021 448 823334 SGTC_2452 5863136 48.41 µM 1.40598755153591 0.100379780386818 no 385 0.0798639106546772 469 2184096 SGTC_1357 1503-1303 39.5 µM 1.40435110487659 0.100642781595178 no 386 0.0801071616113918 527 292895 SGTC_818 4072-2707 53.5 µM 1.40279711914415 0.100892995048348 no 387 0.0803386731627472 437 882871 SGTC_2964 9083345 53.42 µM 1.40160519232455 0.101085219077241 no 388 0.0805165878119099 434 17741579 SGTC_1471 k673-0312 37 µM 1.40087824840572 0.101202585502348 no 389 0.0806252421510304 462 24099884 SGTC_2768 sulfasalazine 50.2 µM 1.40057166498865 0.101252113715112 no 390 0.0806710995310959 470 5384001 An antioxidant and salicylic acid derivative. SGTC_2045 5106652 78.05 µM 1.39976965415284 0.101381761207456 no 391 0.080791153895073 454 673349 SGTC_392 N-ethylmaleimide 8.33 µM 1.3995004640494 0.101425303702043 no 392 0.0808314796423265 456 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides. SGTC_1107 amlodipine 47 µM 1.39937839806832 0.10144505281426 no 393 0.0808497706185157 493 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.  SGTC_3317 9138495 8.753 µM 1.39901955555834 0.101503126332012 no 394 0.0809035594678885 503 17020139 SGTC_853 0419-0306 21 µM 1.39891982641723 0.101519270363169 no 395 0.0809185132057282 452 762713 SGTC_2155 5570423 76 µM 1.39547758828147 0.10207764238219 no 396 0.0814359342710066 469 797402 SGTC_1669 st015249 58.4 µM 1.39534986832992 0.102098402986689 no 397 0.0814551804340677 445 722793 SGTC_3024 9090631 49.47 µM 1.39303083804303 0.102475890809766 no 398 0.0818052327807704 430 25236383 SGTC_909 3448-9333 149 µM 1.39164737489903 0.102701571311556 no 399 0.0820146026939728 443 3344074 SGTC_867 0518-0118 155 µM 1.39113938821016 0.102784528372486 no 400 0.0820915814085798 489 6848158 SGTC_3158 9100007 49.47 µM 1.39112333150845 0.10278715131514 no 401 0.082094015478088 414 19297233 SGTC_231 b-estradiol 524 µM 1.38897983551127 0.103137738908474 no 402 0.0824194409145207 419 450 A steroid. SGTC_2906 7926292 26.41 µM 1.38709329383413 0.103447017177282 no 403 0.0827066583326004 496 2966319 SGTC_996 3970-0799 1.8 µM 1.38326582125038 0.104076557416671 no 404 0.0832916869641214 650 6615648 YGL040C HEM2 SGTC_3254 9136651 49.47 µM 1.3832152308688 0.104084897049548 no 405 0.0832994404750307 512 16454030 SGTC_806 3966-4455 5.86 µM 1.38297627489269 0.104124294586457 no 406 0.083336070339352 433 714982 SGTC_1734 st037168 69.4 µM 1.38059046547414 0.10451824457838 no 407 0.0837024582971518 489 708907 SGTC_680 0417-1641 114 µM 1.37852722951431 0.104859800301182 no 408 0.08402028338833 446 2835990 SGTC_2800 7887935 81.82 µM 1.37756332009509 0.105019646117557 no 409 0.0841690761443595 474 2961002 SGTC_2536 dehydroabietamide 32.04 µM 1.37464431584023 0.105504782389198 no 410 0.0846208712421839 538 3983547 SGTC_163 TUB2.036 7.546 µM 1.3707864064968 0.106148447754789 no 411 0.0852207748440069 675 15992207 YJR013W GPI14 SGTC_1576 erythromycin ethylsuccinate 23.2 µM 1.36753798546177 0.106692620278971 no 412 0.0857283697060757 519 3256 An antibiotic and ribosome inhibitor. SGTC_2343 7990716 14.84 µM 1.36580849761505 0.106983162489143 no 413 0.0859995392643951 517 6456862 SGTC_573 3702-0553 84.7 µM 1.36464599512004 0.107178775483347 no 414 0.0861821705124613 499 1222756 SGTC_713 1488-1073 324 µM 1.34563911123006 0.110413690453452 no 415 0.0892094659025431 486 3312542 SGTC_97 0535-0701 19.132 µM 1.34069931075053 0.111265774515528 no 416 0.0900090492211876 478 2832013 YGL099W LSG1 SGTC_849 0386-0493 241 µM 1.33844930330888 0.111655442979913 no 417 0.0903750080271101 489 726119 SGTC_3140 9094243 49.47 µM 1.3356467688605 0.112142165160799 no 418 0.0908323779149342 525 19291112 SGTC_1657 st012939 43.4 µM 1.33387593201195 0.112450491031022 no 419 0.0911222602638397 481 24207257 SGTC_2114 5491910 81.25 µM 1.33375722918887 0.112471180383167 no 420 0.0911417161803888 521 2849228 SGTC_685 1278-0033 54.9 µM 1.33145663214433 0.112872700981888 no 421 0.091519402864869 553 3590572 SGTC_706 4262-0057 46.9 µM 1.33067680483213 0.11300903529818 no 422 0.0916476891901979 520 883298 SGTC_2386 9075165 157.42 µM 1.32823139950066 0.113437318442979 no 423 0.0920508371824808 490 16452277 SGTC_2090 5301565 104.445 µM 1.32756553764744 0.113554136332292 no 424 0.092160837860645 592 2056344 SGTC_1898 st060199 18.6 µM 1.32654464524994 0.113733406818251 no 425 0.0923296786701243 493 688866 SGTC_2795 7780010 54.55 µM 1.3258763352463 0.113850872421688 no 426 0.0924403313728265 488 953673 SGTC_2571 chrysanthemic acid 100 µM 1.32319950828694 0.114322231894694 no 427 0.0928845197478834 498 2743 An insecticide. SGTC_375 3970-0961 9.27 µM 1.32190858532217 0.11455004505286 no 428 0.0930992966089206 528 2898222 SGTC_981 1488-1094 54.9 µM 1.31977327141142 0.11492757939954 no 429 0.093455364057385 466 3449522 SGTC_2703 st077852 53.4 µM 1.31781302984776 0.11527493845929 no 430 0.0937831225025716 503 6281836 SGTC_280 3448-3607 3.04 µM 1.31660659367954 0.115489092197871 no 431 0.0939852637392099 514 626179 SGTC_2685 mycophenolic acid 18.85 µM 1.31543685016406 0.1156970024278 no 432 0.0941815638584 476 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_2357 9067248 200 µM 1.31182280873468 0.116341041367923 no 433 0.0947899635977397 488 9150235 SGTC_2316 5844804 197.44 µM 1.31123335042273 0.116446326366783 no 434 0.0948894690585627 660 776813 SGTC_2836 9010338 19.48 µM 1.31067416207111 0.116546267205727 no 435 0.0949839358123582 494 2994051 SGTC_1596 piperlongumine 63 µM 1.29936752857732 0.118580105393671 no 436 0.0969089148858827 592 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_296 1222-0039 74.9 µM 1.29801131687593 0.118825735207932 no 437 0.0971417230976951 522 5984176 SGTC_1458 k015-0034 6.33 µM 1.29633901750026 0.119129107635561 no 438 0.0974293558984362 509 3598957 SGTC_1143 3454-2408 5.08 µM 1.29560766441558 0.11926195436798 no 439 0.0975553436120036 471 X1143 SGTC_1521 st012942 49.4 µM 1.29459130689636 0.119446744333333 no 440 0.0977306264019611 593 24207259 SGTC_801 0866-0028 10.1 µM 1.29100410595066 0.120100568970166 no 441 0.0983511268758596 590 6849771 SGTC_1776 st049249 45.9 µM 1.29098197104103 0.120104611224856 no 442 0.0983549646246322 578 1822314 SGTC_1290 0986-0249 10.2 µM 1.28625116184586 0.120970747815864 no 443 0.099177710437941 502 53329 SGTC_283 0987-0079 11.7 µM 1.2850728025831 0.121187168816662 no 444 0.0993834222940593 595 411556 SGTC_2382 9035899 200 µM 1.28175865746495 0.121797314217323 no 445 0.0999636605361227 571 6462679 SGTC_258 haloperidol 50.781 µM 1.27620340749419 0.122824889344896 no 446 0.100941812210137 555 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_650 1328-0195 38 µM 1.27244938694155 0.123522717536679 no 447 0.101606748108003 582 2780821 SGTC_2359 9039622 200 µM 1.27039724882441 0.123905357546143 no 448 0.101971581380273 596 6463596 SGTC_2781 5567276 71.43 µM 1.25863196540692 0.126115113992418 no 449 0.104081647825206 553 2853274 SGTC_264 promethazine 12.5 mM 1.25832629699908 0.126172888498719 no 450 0.104136887281567 712 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3 SGTC_1287 0971-0001 34.6 µM 1.25769840834552 0.126291623844522 no 451 0.104250424055531 624 4665869 SGTC_1071 trifluoperazine 6.31 µM 1.25571787648438 0.126666657560642 no 452 0.104609137759457 597 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. SGTC_1275 0867-0008 21.1 µM 1.2530992856652 0.12716370382404 no 453 0.105084787994264 575 3422836 SGTC_2233 sulbentine 40.3845 µM 1.25033619645088 0.127689647709528 no 454 0.105588380594734 640 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58 SGTC_2976 9009005 19.48 µM 1.25026633589757 0.127702964979199 no 455 0.105601135756046 576 2993148 SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM 1.24961247223528 0.127827655497164 no 456 0.105720572403285 637 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_2211 7117706 200 µM 1.24779341219457 0.128174991700346 no 457 0.106053360922388 547 822771 SGTC_413 propylparaben 100 µM 1.24393478510917 0.128913936707466 no 458 0.106761782847085 569 7175 A pharmaceutical preservative. SGTC_2157 5649910 96.377 µM 1.24060648402403 0.129553691008756 no 459 0.107375577739518 612 2858091 SGTC_1766 st045414 44.774 µM 1.24056039372798 0.129562565735506 no 460 0.107384095387654 616 253960 SGTC_1746 st038117 42 µM 1.23874383184211 0.129912681754809 no 461 0.107720190361424 602 2898218 SGTC_920 mycophenolic acid 780.421 nM 1.23686684313545 0.130275131648956 no 462 0.108068260684801 596 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_632 0781-2353 4.65 µM 1.23644553076178 0.130356583875256 no 463 0.108146500350042 624 6811515 YHR007C ERG11 SGTC_1865 st057639 52.2 µM 1.23623587442863 0.130397129811267 no 464 0.108185449696092 591 688818 SGTC_3048 9093155 49.47 µM 1.23617626127648 0.130408660132909 no 465 0.108196526298241 519 25236002 SGTC_2207 7258803 200 µM 1.23491838008656 0.130652122812466 no 466 0.108430441087335 527 3666799 SGTC_128 0906-2981 13.371 µM 1.23452524022265 0.130728279377338 no 467 0.10850362370523 530 6740226 SGTC_96 0929-0093 37.281 µM 1.22983659717489 0.131638899214115 no 468 0.109379150296605 554 6991579 SGTC_1194 1488-0194 225 µM 1.22960269146822 0.131684442319199 no 469 0.109422960832648 632 1391452 SGTC_1964 st076914 61 µM 1.2274522679443 0.132103654571133 no 470 0.109826325796781 584 24208661 SGTC_2180 6301957 200 µM 1.22731773648007 0.132129911229352 no 471 0.109851595915056 588 845462 SGTC_1761 st044296 37 µM 1.22487200557587 0.132607874683061 no 472 0.110311724770788 587 1826700 SGTC_1283 0922-0125 16.4 µM 1.22421339504418 0.132736788701313 no 473 0.110435868676696 648 3360884 SGTC_3078 9116413 49.47 µM 1.22400259202463 0.132778068742432 no 474 0.110475624861383 545 17177322 SGTC_3176 9106582 49.47 µM 1.22298594496859 0.132977275562811 no 475 0.110667502461103 423 17018027 SGTC_2283 7944793 200 µM 1.22222928706325 0.133125672319166 no 476 0.110810465771991 602 2970533 SGTC_396 dithiazanine 1.25 µM 1.22071147119307 0.133423691908898 no 477 0.111097641471953 570 10578 An antihelmenthic. SGTC_2367 9070478 135.38 µM 1.21973899651702 0.133614876062312 no 478 0.111281916748997 631 572802 SGTC_104 0074-0074 590.992 µM 1.21651365193505 0.134250312347709 no 479 0.11189465685553 460 3943124 SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM 1.21018865248357 0.13550244047371 no 480 0.113103255680287 539 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding. SGTC_1820 st053765 18.6 µM 1.2085032407821 0.135837438869794 no 481 0.11342687499111 580 3690829 SGTC_3150 9097574 49.47 µM 1.20729062932918 0.136078812351908 no 482 0.113660119087826 581 17217476 SGTC_1828 st055811 49 µM 1.2030282908985 0.136929570679721 no 483 0.114482686437309 561 5877589 SGTC_1375 2910-0797 186 µM 1.20302679747024 0.136929869402084 no 484 0.114482975387243 621 742508 SGTC_1859 st055998 20 µM 1.2007004754948 0.137395731732347 no 485 0.114933704812149 644 676301 SGTC_3107 9121808 49.47 µM 1.19468546351647 0.138605292554676 no 486 0.116104972010236 530 662681 SGTC_414 piperonyl butoxide 100 µM 1.19319237964432 0.138906657796944 no 487 0.116397019202039 619 5794 A potent inhibitor of cytochrome P450. SGTC_105 0111-0055 734.78 µM 1.19219333397807 0.139108554938425 no 488 0.11659272330673 542 5179370 SGTC_408 cantharidin 100 µM 1.18892155255812 0.139771146919933 no 489 0.11723526906441 640 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_1773 st048542 73.5835 µM 1.18749639784626 0.140060434983849 no 490 0.117515938298693 641 3237138 SGTC_1087 pterostilbene 9.05 µM 1.18662073821043 0.140238384251277 no 491 0.117688626027862 664 5281727 Similar to reservatol, lowers cholesterol. SGTC_613 3914-0030 117 µM 1.18558279946678 0.140449510262902 no 492 0.117893549136754 372 1145395 SGTC_2581 avocatin a 64 µM 1.18456334618998 0.14065708613321 no 493 0.11809506823349 663 6710728 A skin care supplement. SGTC_1736 st036774 51 µM 1.18244428066082 0.141089225351741 no 494 0.118514730972324 662 1272247 SGTC_2206 7254556 146.969 µM 1.18208786546175 0.141161997153766 no 495 0.118585419357482 588 4398905 SGTC_1531 st059297 52.4 µM 1.18087218538705 0.141410402539037 no 496 0.118826751193026 659 7566702 SGTC_1772 st048439 82.2 µM 1.18004752692669 0.141579077260042 no 497 0.118990656367327 645 2927068 YDL195W SEC31 SGTC_215 1287-0124 461.5 µM 1.17817663090442 0.141962253494388 no 498 0.119363098481586 580 5560863 SGTC_3172 9105863 49.47 µM 1.17702334356133 0.142198806537113 no 499 0.119593094575528 553 2348785 SGTC_2855 9016525 58.44 µM 1.17399749802845 0.142820711109712 no 500 0.120198013889721 643 43811474 SGTC_2023 5144124 124 µM 1.17396567013863 0.142827262478423 no 501 0.120204388277365 636 2830192 SGTC_266 formosanin C 406 nM 1.17192483086808 0.143247767561384 no 502 0.120613618406628 659 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1 SGTC_1198 1612-1005 86.7 µM 1.17159512791568 0.143315779636181 no 503 0.120679822536694 658 6998509 SGTC_1857 st056007 79.3 µM 1.1693889708483 0.14377143316067 no 504 0.121123475711946 616 619834 SGTC_671 0560-0003 407 µM 1.16723892013836 0.144216438151554 no 505 0.121556948710121 616 3238678 SGTC_268 camptothecin 39.6153 µM 1.16623957876197 0.14442359178969 no 506 0.121758797263833 750 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_1136 pergolide 1.05886 µM 1.16597970554775 0.144477493786848 no 507 0.12181132542839 742 47811 A dopamine receptor agonist. SGTC_2212 7123476 200 µM 1.16482330941788 0.14471751379818 no 508 0.122045260782655 541 1085715 SGTC_2763 lisinopril 49.32 µM 1.16464697465998 0.144754137185887 no 509 0.122080960462245 604 5362119 A lysine-analog of enalapril and an ACE inhibitor. SGTC_236 1509-0011 5.31 µM 1.16236945327373 0.145227721990035 no 510 0.122542712891754 913 3107280 SGTC_2615 purpurogallin-4-carboxylic acid 100 µM 1.16180548848436 0.145345152946699 no 511 0.122657242072683 685 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase. SGTC_866 0495-0101 262 µM 1.16035490484313 0.145647492533657 no 512 0.122952169451165 622 635694 SGTC_1438 4092-1045 4 µM 1.15932383251567 0.14586265189909 no 513 0.123162105391004 664 1351342 SGTC_2280 7785178 200 µM 1.15802204404049 0.146134608004761 no 514 0.123427520314401 623 2954328 SGTC_2561 acetosyringone 100 µM 1.15635942349911 0.146482440380988 no 515 0.123767085721196 738 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent. SGTC_917 harmaline 728.087 nM 1.15473890046609 0.146822000056441 no 516 0.124098682200733 658 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7 SGTC_1572 epiandrosterone 68.9 µM 1.15430985166949 0.146911990028841 no 517 0.124186579480677 710 441302 A steroid. SGTC_21 0849-0113 22.993 µM 1.15294140408206 0.147199259425617 no 518 0.124467218068289 669 1560156 SGTC_2750 bromebric acid 70.15 µM 1.15289376932592 0.147209265860741 no 519 0.124476994891945 725 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2 SGTC_2205 7238770 200 µM 1.15100801623262 0.147605764513625 no 520 0.124864468843463 638 279867 SGTC_3187 9109394 49.47 µM 1.15087848471335 0.147633026056492 no 521 0.124891115149418 665 17098090 SGTC_1026 k007-1105 30.6 µM 1.15056331428008 0.147699371736342 no 522 0.124955966369492 730 7066794 SGTC_2960 9079389 5.97 µM 1.14701138211153 0.148448459915334 no 523 0.125688458396653 678 16457355 SGTC_665 3914-0008 307 µM 1.14683940849594 0.148484792829007 no 524 0.125723999277365 651 1069549 SGTC_1097 itavastatin 7.23 µM 1.14233817203536 0.149437885111813 no 525 0.126656740112305 693 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49 SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM 1.14216886632246 0.149473813429668 no 526 0.126691917235037 654 756377 SGTC_3156 9099931 49.47 µM 1.14079310431358 0.149765977259805 no 527 0.126978015437072 702 18111053 SGTC_1638 st008370 60.6 µM 1.1382660655611 0.150303623975579 no 528 0.127504699649426 676 24207134 SGTC_2644 guaiazulene 100 µM 1.13210994549753 0.151618762493115 no 529 0.128794107055816 668 3515 A coloring agent. SGTC_1431 4049-0260 9.09 µM 1.13198635506505 0.151645243334363 no 530 0.128820085525208 689 3854841 SGTC_2338 7999974 200 µM 1.13073597776287 0.151913325638726 no 531 0.129083116833254 741 315925 SGTC_1529 apigenin 74 µM 1.13034633038588 0.151996930779956 no 532 0.129165159709084 704 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_322 k048-0136 19.3 µM 1.12998201267543 0.152075128673436 no 533 0.129241901947933 649 6823282 SGTC_2409 alverine citrate 63.97 µM 1.12938271999956 0.152203820184826 no 534 0.129368209577115 673 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_2783 7738165 71.43 µM 1.12670404432403 0.152779919998065 no 535 0.12993381596736 582 17201110 SGTC_2909 7941780 10.49 µM 1.12373263539218 0.153420667385505 no 536 0.130563233547395 707 1243215 SGTC_617 3770-0098 35 µM 1.12362358260919 0.153444217076007 no 537 0.13058637365179 644 5962639 SGTC_1253 0550-0034 176 µM 1.12283483440254 0.153614616667916 no 538 0.130753823967787 642 5969915 SGTC_2449 5812982 45.77 µM 1.12123804649396 0.153959967000968 no 539 0.13109327440227 640 776185 SGTC_842 0271-0008 11.1 µM 1.1197654406573 0.154278914493658 no 540 0.131406864966552 740 1221709 SGTC_1563 conessine 56.1 µM 1.1195542085714 0.154324700455567 no 541 0.13145188915507 794 441082 An anti-amoebic, histamine inhibitor. SGTC_2323 6148992 148.28 µM 1.11856892504128 0.154538385913337 no 542 0.131662043351386 619 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42 SGTC_108 0509-0257 621.132 µM 1.11779811788848 0.154705692630756 no 543 0.131826612772719 731 536624 SGTC_1567 st069303 68.4 µM 1.117763078722 0.154713300862179 no 544 0.131834097100551 705 5581319 SGTC_1291 0993-0025 5.79 µM 1.11687498363238 0.154906219982833 no 545 0.132023891121989 714 4353356 SGTC_2079 5212404 121 µM 1.11674853876677 0.154933700264163 no 546 0.132050928859621 698 758462 SGTC_2856 9022925 19.48 µM 1.11456677239739 0.155408370925165 no 547 0.132518057930246 698 4944862 SGTC_1127 asiatic acid 681.4 nM 1.114349912008 0.155455603999906 no 548 0.132564551152716 665 470603 A kinase inhibitor which arrests cells at G2/M. SGTC_3252 9135871 49.47 µM 1.11370720614246 0.155595643577751 no 549 0.132702408417189 689 17682838 SGTC_1161 k007-0610 110 µM 1.11370076340551 0.155597047810805 no 550 0.13270379085245 788 5843850 SGTC_42 0133-0086 60.653 µM 1.11356680264123 0.155626247254511 no 551 0.132732537418514 613 162923 Model of phenazepam hydroxylation. SGTC_2115 tiliquinol 12.7705 µM 1.1132634229372 0.15569238832456 no 552 0.132797655354823 679 71208 A bioactive hydroxyquinoline. SGTC_3040 9091894 49.47 µM 1.11116614058008 0.156150132550277 no 553 0.133248421337679 620 25236966 SGTC_1825 st052143 62.6 µM 1.11091845464686 0.156204249949867 no 554 0.133301725558566 657 674173 SGTC_2239 6685329 187.64 µM 1.11082361768675 0.156224974339797 no 555 0.133322139201431 688 805680 SGTC_691 1548-0686 185 µM 1.11078679470498 0.156233021625693 no 556 0.133330065922919 713 46495133 SGTC_1120 ficusin 1.78878 µM 1.11021667841543 0.156357649551724 no 557 0.13345283372377 710 6199 A DNA cross-linker. SGTC_2152 5568786 200 µM 1.10986517690319 0.156434520715229 no 558 0.133528564152994 677 5399883 SGTC_639 0833-0042 114 µM 1.1095453147193 0.156504494181878 no 559 0.133597503619958 735 5978911 YPR085C | YHR062C ASA1 | RPP1 SGTC_341 1486-1430 230 µM 1.10745952332705 0.156961289903126 no 560 0.134047651579914 680 2054753 YPL210C SRP72 SGTC_1610 st001799 48.1 µM 1.10697287662458 0.157067993325541 no 561 0.134152827672232 628 621897 SGTC_2419 paclitaxel 166.5 µM 1.10521803273523 0.157453161081334 no 562 0.134532562466042 735 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_2081 5214970 32.255 µM 1.10497055623278 0.157507529188009 no 563 0.134586173794922 688 2063512 SGTC_1913 st060213 96.1 µM 1.1037879086656 0.157767515330678 no 564 0.134842575567968 739 688959 SGTC_2085 5307070 144.047 µM 1.09937716285915 0.158739631774444 no 565 0.135801793856094 649 2840351 SGTC_1484 3473-2379 286 µM 1.09743069581017 0.159169874020912 no 566 0.136226580548185 815 671917 SGTC_3205 9113483 49.47 µM 1.09729638746597 0.159199589348487 no 567 0.136255924789753 727 17018033 SGTC_2849 9019321 12.99 µM 1.0968317380055 0.159302419707545 no 568 0.136357476686175 665 16489627 SGTC_2147 5545932 89.7195 µM 1.09542329473666 0.159614384291428 no 569 0.13666561662486 687 797404 SGTC_2499 avocadenofuran 51.48 µM 1.09510410332647 0.159685139454163 no 570 0.136735515610475 677 6857792 A insecticide and lysyl oxidase inhibitor. SGTC_2086 5274770 176.623 µM 1.09422551879854 0.159880001272446 no 571 0.136928041006101 690 689278 SGTC_2150 5556613 200 µM 1.093566626309 0.160026239472852 no 572 0.137072546502031 743 743190 SGTC_1227 3909-8010 46.6 µM 1.09034955706482 0.160741509108628 no 573 0.137779596487512 702 15982272 SGTC_2478 5763493 32.33 µM 1.09032706000333 0.160746518349867 no 574 0.137784549655421 746 1365576 YLR208W SEC13 SGTC_2645 abamectin 100 µM 1.0898091662339 0.160861861807209 no 575 0.137898607686814 695 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels. SGTC_525 k781-2675 26.7 µM 1.08938418732105 0.160956551948989 no 576 0.137992250769253 728 3651118 YDL195W SEC31 SGTC_452 diindolylmethane 8 µM 1.08852934898706 0.161147129833907 no 577 0.138180743684071 658 3071 Inhibits expression of several cancer promoting factors. SGTC_1183 1254-0324 198 µM 1.08666299157429 0.161563727463455 no 578 0.138592887633905 727 5799357 SGTC_1347 1493-0251 600 nM 1.08585695202272 0.161743863905328 no 579 0.138771142422111 770 3986378 SGTC_679 0422-0091 41.4 µM 1.08497708112361 0.161940649791125 no 580 0.13896590311983 760 627384 YHR062C RPP1 SGTC_877 0771-0151 33.1 µM 1.07927328928997 0.163220101651109 no 581 0.140232958269308 737 6166523 SGTC_3029 9088683 49.47 µM 1.0787647811385 0.163334486217924 no 582 0.140346299348811 697 25236615 SGTC_1691 st019933 84.6 µM 1.07655020115545 0.163833244161056 no 583 0.140840631027504 715 6176082 SGTC_1552 6-methylflavone 10.6 µM 1.07645863290871 0.163853888015567 no 584 0.140861096007801 677 689013 SGTC_494 Boc-Gly-Val-Val-CHO 140 µM 1.07336900942083 0.164551425996724 no 585 0.1415527917507 710 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA. SGTC_4 0960-0234 25.671 µM 1.07336030490892 0.164553393911172 no 586 0.141554743736327 685 6821112 SGTC_3025 9087895 49.47 µM 1.07223805751536 0.164807239138096 no 587 0.141806560322094 789 17173641 SGTC_2879 9041815 71.43 µM 1.07086771150471 0.165117546466403 no 588 0.142114457914561 630 4942971 SGTC_2820 7989630 71.43 µM 1.07007919609266 0.16529627276793 no 589 0.142291831243642 617 2984098 SGTC_1962 st076595 64.5 µM 1.06986927776513 0.165343874320304 no 590 0.142339076751224 728 279619 SGTC_350 k064-0020 19.8 µM 1.06869707352358 0.165609849027799 no 591 0.142603095321502 775 2790705 SGTC_1908 st060353 56.5 µM 1.06833423789498 0.16569223296297 no 592 0.142684884793591 795 4227716 SGTC_695 3505-6186 243 µM 1.06795204276658 0.16577904123755 no 593 0.142771072527462 759 1819379 SGTC_469 w7 172 µM 1.06691707624947 0.166014261564818 no 594 0.143004641532481 699 45115570 A P450 inhibitor. SGTC_893 0958-0369 48.9 µM 1.06472385024406 0.166513435797478 no 595 0.143500456924959 773 6819948 SGTC_1741 st038134 10.228 µM 1.06065503231214 0.167442054539388 no 596 0.144423351431188 789 1272587 SGTC_92 0063-0024 660.874 µM 1.05521672439393 0.168688429446284 no 597 0.145663108465568 824 3594437 SGTC_2601 securinine 100 µM 1.05481832335038 0.168779970538263 no 598 0.145754211364461 710 442872 A GABA receptor antagonist. SGTC_227 fluconazole 33.516 µM 1.05328283107614 0.169133080997591 no 599 0.146105692652937 789 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C SGTC_2747 doxorubicin 7.63 µM 1.05232265975068 0.169354128296064 no 600 0.146325769412619 569 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_1763 st044482 94.5 µM 1.05042678640122 0.169791133911808 no 601 0.146760967786998 772 88505 SGTC_74 000s-0487 160.283 µM 1.04923852573785 0.170065400582469 no 602 0.147034175691252 741 677548 SGTC_3318 9139014 38.6185 µM 1.04839325008092 0.170260674399714 no 603 0.14722873107693 719 16643984 SGTC_1555 citronellol 128 µM 1.04804522941667 0.170341115137606 no 604 0.147308884415967 731 8842 A terpine precursor. SGTC_2278 7948257 134.34 µM 1.04654505492867 0.170688140784577 no 605 0.147654727315421 763 1247028 SGTC_2260 7964312 200 µM 1.04357977663903 0.171375409662567 no 606 0.148339926748706 706 231951 SGTC_1939 st074455 53.6 µM 1.04332463413826 0.171434627119322 no 607 0.148398982824528 773 1644229 SGTC_790 1575-0012 79.1 µM 1.04053263291882 0.17208349278207 no 608 0.149046255567953 781 378741 YLR208W SEC13 SGTC_3119 9125183 49.47 µM 1.03652264912009 0.173018158224485 no 609 0.149979189297512 613 22695334 SGTC_140 0062-0056 502.533 µM 1.03343460558878 0.173740133610434 no 610 0.15070027941821 814 3758964 SGTC_1330 1469-0054 61.8 µM 1.03230733609067 0.174004162658363 no 611 0.150964082748195 821 7102664 SGTC_319 1348-1596 45.5 µM 1.03203041993797 0.17406906096593 no 612 0.151028933592703 809 5380505 SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM 1.03159079023842 0.174172124561127 no 613 0.151131928308665 834 91467 include heat shock SGTC_2259 7964009 200 µM 1.03122078223142 0.174258896602696 no 614 0.15121864853652 725 313134 SGTC_2508 celastrol 40.54 µM 1.03068866592876 0.174383733452498 no 615 0.151343420742851 720 122724 Celastrol is a natural product and antioxidant. SGTC_1900 st060200 72.8 µM 1.02962247267369 0.174634038048365 no 616 0.151593630876509 779 688945 SGTC_2541 muurolladie-3-one 83.07 µM 1.02957915889333 0.174644211417018 no 617 0.151603801396966 738 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils.  YMR203W TOM40 SGTC_989 1501-0895 10.3 µM 1.02598568938224 0.175489541689332 no 618 0.152449164796758 790 2830112 SGTC_3004 9076122 71.4286 µM 1.02581559564069 0.175529618839915 no 619 0.152489256728421 789 44782551 SGTC_339 3091-4833 71.4 µM 1.02485722491087 0.175755536658573 no 620 0.1527152801836 771 3240077 SGTC_2804 7954240 19.48 µM 1.0247194102463 0.175788039007709 no 621 0.152747800847223 819 828705 SGTC_2470 5664817 21.68 µM 1.02386701783768 0.175989152683647 no 622 0.152949045263039 769 2859561 SGTC_272 doxorubicin 8.13 µM 1.02329282777975 0.176124709318163 no 623 0.153084706922935 811 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_1802 st050112 57.9 µM 1.02283475086839 0.176232900971919 no 624 0.153192992157607 780 4662563 SGTC_403 arphamenine a 50 µM 1.02204895590008 0.176418593195807 no 625 0.153378865167872 761 5487158 An arginine aminopeptidase inhibitor. SGTC_1378 2093-0007 380 nM 1.02101961730036 0.176662024723043 no 626 0.153622572259036 765 3618014 SGTC_2429 5902844 64.44 µM 1.0206558498813 0.176748103993469 no 627 0.153708759429553 814 1927790 YGL093W | YPR107C SPC105 | YTH1 SGTC_537 1334-0398 209 µM 1.01902201118918 0.177135050590744 no 628 0.154096258441915 812 5846986 SGTC_3017 9080681 49.47 µM 1.01622928341447 0.177797698135433 no 629 0.154760107361963 768 16451914 SGTC_3218 9131285 49.47 µM 1.01512397601479 0.178060392519939 no 630 0.155023366990332 865 17156417 SGTC_2227 7312221 64.1025 µM 1.01486101683207 0.178122925086195 no 631 0.155086041536585 812 887188 YOR168W | YOR169C GLN4 | YOR169C SGTC_2802 7925815 54.55 µM 1.01470568045868 0.178159871094759 no 632 0.155123072772149 781 1262923 SGTC_1195 1502-0147 41.1 µM 1.01244094152897 0.178699076850622 no 633 0.155663635568724 816 817940 SGTC_3341 9147222 25.867 µM 1.01200753008502 0.178802383659387 no 634 0.155767226522683 744 1939759 SGTC_2829 7992743 58.44 µM 1.01103896042253 0.179033385221174 no 635 0.155998891493891 806 16462845 SGTC_2215 7188065 200 µM 1.0074694803961 0.179886317866409 no 636 0.156854608438495 753 940217 SGTC_1523 st012844 44.7 µM 1.0065378441631 0.18010935304875 no 637 0.157078458332222 795 4274103 SGTC_516 3992-2719 87.3 µM 1.00318379763842 0.180913753754072 no 638 0.157886094484374 743 5350887 YDR037W KRS1 SGTC_2996 9066192 71.4286 µM 1.00212986430747 0.181166982689641 no 639 0.158140437949992 776 6472854 SGTC_2183 6420625 130.508 µM 0.999803907957147 0.181726626252164 no 640 0.158702707117278 851 2897619 SGTC_1395 3486-0190 4.35 µM 0.998904025335942 0.18194343502261 no 641 0.158920593037779 851 6748079 SGTC_1719 st032227 49.2 µM 0.998203859605425 0.182112237833749 no 642 0.159090257637196 782 3125804 SGTC_2436 5633522 8.09 µM 0.997826822682807 0.182203178129241 no 643 0.159181670598485 820 5724242 SGTC_527 4476-4215 268 µM 0.995058154394855 0.182871842684642 no 644 0.159853990565873 795 4418754 SGTC_2932 9016711 44.54 µM 0.994291286550662 0.183057320418317 no 645 0.160040538280909 843 7117328 SGTC_3233 9132340 49.47 µM 0.993427371556644 0.183266410895322 no 646 0.160250864060672 791 17682950 SGTC_783 0848-0141 92.7 µM 0.993226656976848 0.183315010490849 no 647 0.160299755195395 768 6755076 YHR007C | YLR033W ERG11 | RSC58 SGTC_1245 0418-0076 17.2 µM 0.992662036178567 0.18345176683448 no 648 0.160437340838374 809 6790114 SGTC_2973 9094665 17.96 µM 0.992605362049243 0.183465497340495 no 649 0.160451155334299 865 25237061 YIL048W NEO1 SGTC_1732 st034308 51.822 µM 0.99167321317569 0.183691422019369 no 650 0.160678481041077 763 830119 SGTC_1 0258-0098 57.368 µM 0.99047855178302 0.183981225102613 no 651 0.160970133777036 708 6790032 YDR047W HEM12 SGTC_2333 9017922 200 µM 0.988954132146801 0.184351434679343 no 652 0.161342791846823 808 3163164 SGTC_2890 9046729 58.44 µM 0.987599971092698 0.184680684918039 no 653 0.161674300228346 745 903329 SGTC_2618 avocadyne 43.43 µM 0.986902062488793 0.184850516847364 no 654 0.161845326526565 803 3015189 SGTC_3237 9133362 49.47 µM 0.980836761908362 0.186330556352659 no 655 0.163336623224582 829 43845137 SGTC_870 0573-2213 57.6 µM 0.979377802451819 0.186687660434805 no 656 0.163696670405376 792 3916321 SGTC_378 3970-0959 8.33 µM 0.977688136423933 0.187101762800141 no 657 0.164114295550158 821 6615653 SGTC_3346 9158254 43.5805 µM 0.97758252185824 0.187127665608717 no 658 0.164140422630641 819 17639500 SGTC_2986 9022445 71.43 µM 0.975254465052232 0.187699203141426 no 659 0.164717025711795 835 6459286 SGTC_3250 9135583 49.47 µM 0.975155395972459 0.187723548479248 no 660 0.164741591789122 804 7699353 SGTC_3149 9097855 49.47 µM 0.971382980328421 0.188652036561272 no 661 0.165678800319757 820 25236625 YMR079W SEC14 SGTC_328 k915-0120 63.5 µM 0.967767830342706 0.189544468995825 no 662 0.166580166710917 837 6624543 SGTC_1043 0916-0009 19.3 µM 0.967143784896036 0.189698782728504 no 663 0.166736079887637 947 3101130 SGTC_3083 9117465 49.47 µM 0.966568599176852 0.189841082858382 no 664 0.166879869182284 826 16420915 SGTC_1262 0737-0114 49.6 µM 0.964229965648961 0.190420333134952 no 665 0.167465322025881 908 765919 SGTC_2033 5192550 145 µM 0.963907195186455 0.190500364494454 no 666 0.167546228090109 801 182073 SGTC_1886 st057356 49.9 µM 0.961714064231665 0.191044700932579 no 667 0.16809662779991 799 24207747 SGTC_34 0469-0683 81.75 µM 0.957705541346439 0.192042080726621 no 668 0.169105630862669 853 3690923 SGTC_3278 9139605 49.47 µM 0.956998412943393 0.19221835478587 no 669 0.169284028027381 822 7958859 SGTC_1252 0493-0875 34.8 µM 0.956512496187768 0.192339542219215 no 670 0.169406687044921 811 3960963 SGTC_1721 st082152 9.2685 µM 0.955366752634251 0.19262547509601 no 671 0.169696130591919 803 5296051 SGTC_134 0269-0018 6.916 µM 0.954946636657232 0.192730384707704 no 672 0.169802341850842 807 4378915 SGTC_2485 5633444 17.78 µM 0.954489257512427 0.192844639208076 no 673 0.169918022222618 804 5724239 SGTC_2020 4017018 200 µM 0.953829165844627 0.193009604752213 no 674 0.170085061717463 826 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope. SGTC_209 4077-0173 175.592 µM 0.951595979735032 0.193568345799111 no 675 0.17065096060476 762 15993494 SGTC_3041 9091929 49.47 µM 0.950634669374389 0.19380916816119 no 676 0.170894931416855 885 25236887 SGTC_841 0251-0215 91.2 µM 0.948911093700458 0.194241406210048 no 677 0.171332915900176 898 3888614 SGTC_2123 5259487 200 µM 0.947195587112979 0.194672203137666 no 678 0.171769561808638 889 2173474 SGTC_422 cantharidin 155 µM 0.946243342508059 0.194911580890916 no 679 0.172012242009337 836 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_2721 ifenprodil 61.44 µM 0.944036274611543 0.195467087218481 no 680 0.172575555889402 848 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor. SGTC_1627 st003713 25.6 µM 0.943391995299463 0.195629429768165 no 681 0.172740218011103 927 16195070 YER133W GLC7 SGTC_2545 solidagenone 89.61 µM 0.941886590204475 0.196009073816772 no 682 0.173125353174034 643 6708572 An anti ulcer agent SGTC_819 1013-0258 27.7 µM 0.941511255588047 0.19610379800156 no 683 0.173221461982774 847 5753198 SGTC_2819 7996655 46.38 µM 0.939368463936431 0.196645111474597 no 684 0.173770799285578 761 6456960 SGTC_2931 9014674 55.67 µM 0.93657604698531 0.197351890523162 no 685 0.174488338960568 850 2996810 SGTC_1932 st074806 40.9 µM 0.935728667692542 0.19756667126691 no 686 0.17470645326262 915 17251235 SGTC_387 norethindrone acetate 66.7 µM 0.93548413158869 0.197628678802032 no 687 0.17476942869959 813 541197 SGTC_407 eburnamonine 100 µM 0.934800258888143 0.197802152282705 no 688 0.174945623075055 810 3195 SGTC_2453 5731132 22.18 µM 0.934169898829205 0.197962133022503 no 689 0.175108130137438 916 1362040 SGTC_2121 5257820 149.641 µM 0.93385604977332 0.198041814734596 no 690 0.175189076237738 941 791256 SGTC_1619 st003326 88.7 µM 0.933066159979561 0.198242441964709 no 691 0.175392904967342 841 2849032 SGTC_2287 7945887 168.79 µM 0.932839350188625 0.198300072943152 no 692 0.175451460336371 927 1245853 SGTC_3348 9149464 3.537 µM 0.931737057829652 0.19858030263573 no 693 0.175736215024314 874 1951442 SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM 0.930010582003962 0.199019694773906 no 694 0.176182802783767 799 521171 SGTC_1587 estradiol valerate 56.1 µM 0.929473884526423 0.19915640481048 no 695 0.176321776626582 897 13791 A steroid. SGTC_1511 0906-3109 28.5 µM 0.927493729116248 0.199661288225016 no 696 0.176835123080038 963 2882180 SGTC_558 k064-0027 21.3 µM 0.927016502921918 0.19978308242722 no 697 0.176958982971698 896 5088526 SGTC_2267 7931562 200 µM 0.924041465830036 0.200543356982611 no 698 0.177732363536432 793 934880 SGTC_1699 st031318 29.054 µM 0.922788121989212 0.200864170068851 no 699 0.17805881600115 926 5340658 SGTC_1844 rapamycin 4 nM 0.921260239240626 0.201255671968751 no 700 0.178457287266642 952 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2 SGTC_85 0868-0259 160.055 µM 0.919203362166815 0.201783444314247 no 701 0.178994606441328 839 83173 SGTC_990 3985-0011 41.3 µM 0.917646624488382 0.202183436771407 no 702 0.179401949976264 828 5399565 YGL099W LSG1 SGTC_1675 st018485 24.5 µM 0.917554127166388 0.202207218208549 no 703 0.179426171603816 876 3323024 SGTC_1348 1493-0373 93.8 µM 0.916569172745516 0.202460557760894 no 704 0.179684222230295 878 3010129 SGTC_3127 9126946 49.47 µM 0.915503057047624 0.202734986525205 no 705 0.179963799164348 782 27243249 SGTC_289 k017-0060 526 µM 0.912330875983054 0.203552850983382 no 706 0.180797282701182 892 5512909 SGTC_61 0978-8327 98.565 µM 0.911275310224603 0.203825436931685 no 707 0.181075165985452 914 6150059 YHR072W ERG7 SGTC_925 2064-1272 59.6 µM 0.910322284628554 0.204071730034493 no 708 0.18132628475115 835 6815817 SGTC_1428 4049-0204 61.7 µM 0.908223876912269 0.204614652032878 no 709 0.181879975753181 934 X1428 SGTC_1067 clotrimazole 1.36 µM 0.90688516662474 0.204961465737013 no 710 0.182233763025239 921 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_1785 bathophenanthroline 24 µM 0.906232383888706 0.205130705924059 no 711 0.182406432879503 871 72812 An iron chelator. SGTC_1289 0976-0073 69.1 µM 0.903083574487615 0.205948230676124 no 712 0.183240770427749 933 3391136 SGTC_1407 3909-7909 12.3 µM 0.902915571048627 0.20599190361394 no 713 0.183285352945421 946 4411780 SGTC_1442 4112-3290 3 µM 0.90198648638135 0.206233520789554 no 714 0.18353202319019 935 704353 SGTC_837 0091-0265 12.5 µM 0.901026509502247 0.206483348152936 no 715 0.183787112489338 923 759367 SGTC_1223 0764-0573 147 µM 0.899514012118902 0.206877328734888 no 716 0.184189467832893 947 1609797 SGTC_1328 1441-0025 69.2 µM 0.898178119553048 0.207225676444272 no 717 0.184545298250941 860 4562601 SGTC_1468 k284-1086 134 µM 0.894345159186327 0.208227083866651 no 718 0.185568622432309 963 15996457 SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM 0.893950267391292 0.208330416131453 no 719 0.185674250400834 976 688788 SGTC_1460 k062-0059 9.15 µM 0.891937648590455 0.208857532586499 no 720 0.186213176802525 890 1373085 SGTC_2514 salinomycin 42.74 µM 0.891697325093074 0.208920527168643 no 721 0.186277593841139 1002 23682228 A polyether potassium ionophore. SGTC_1373 2887-0003 58.5 µM 0.890588204007052 0.209211399535122 no 722 0.186575064891072 882 776948 SGTC_2368 9071271 200 µM 0.89050545043012 0.209233111613889 no 723 0.186597271542993 886 27209959 SGTC_166 k072-0058 166.424 µM 0.890108602802704 0.209337251066005 no 724 0.186703787048013 967 5846229 SGTC_1569 carminic acid 40.6 µM 0.888522487105416 0.209753778832743 no 725 0.187129882643766 959 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_2088 5278280 127.392 µM 0.887708675661424 0.209967681801607 no 726 0.18734873898006 941 791502 SGTC_1185 1319-0113 81.3 µM 0.886488877496693 0.210288534650096 no 727 0.187677072532285 889 4672763 SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM 0.886349201694112 0.210325293007882 no 728 0.187714691792204 990 16623 A steroid. SGTC_1103 duloxetine 36.1 µM 0.885482826831296 0.210553380378404 no 729 0.187948138904067 1024 60835 A selective serotonin reuptake inhibitor. SGTC_2240 6690706 185.951 µM 0.885026900396606 0.210673468748839 no 730 0.188071061498929 806 805876 SGTC_295 k015-0027 31 µM 0.884942044243946 0.210695823800289 no 731 0.188093945092363 918 3887424 SGTC_2634 4'-methoxyflavone 100 µM 0.884564705169193 0.210795249288432 no 732 0.188195724864689 856 77793 From seeds of Psoralea corylifolia (Fabaceae) SGTC_568 1193-0097 7.48 µM 0.884226445041431 0.210884401208061 no 733 0.188286992743676 920 3646150 SGTC_1662 st014054 52 µM 0.883599048844393 0.211049816421719 no 734 0.188456346341744 914 2838777 SGTC_3350 9150499 3.57 µM 0.881618317675942 0.211572541979273 no 735 0.188991622993486 970 4910996 YPR165W RHO1 SGTC_3329 9141233 27.5565 µM 0.879989704432889 0.212002908996518 no 736 0.189432443487545 929 4909101 YNL103W MET4 SGTC_35 0133-0054 64.071 µM 0.879655256136672 0.212091351508414 no 737 0.18952304763273 885 99677 SGTC_1827 berberine 7.24 µM 0.879448988466811 0.212145908304692 no 738 0.189578940132119 842 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_148 3253-0744 288.01 µM 0.877295389392232 0.212716014649453 no 739 0.190163107938498 938 6893655 SGTC_2749 bexarotene 57.39 µM 0.876512498130692 0.21292348515037 no 740 0.190375742498138 906 82146 An retinoic acid receptor inhibitor. SGTC_2210 7115885 190.385 µM 0.87520653672833 0.213269834791148 no 741 0.190730768580573 952 2927039 SGTC_799 1310-0557 151 µM 0.87362042175928 0.213690924478082 no 742 0.191162500511463 930 5354492 SGTC_3351 9150312 21.596 µM 0.87333336475722 0.21376718552259 no 743 0.191240699861341 915 4904905 SGTC_3066 9117245 49.47 µM 0.87196304012136 0.214131451408987 no 744 0.191614270441651 995 17176980 SGTC_1140 3229-1848 2.98 µM 0.870469948273249 0.214528762721863 no 745 0.192021817607069 959 2849525 SGTC_1705 st027868 56.3335 µM 0.870238042298861 0.214590511264605 no 746 0.192085165106544 981 292948 SGTC_3258 9138477 49.47 µM 0.867337643010215 0.215363659470681 no 747 0.192878518620403 964 4970355 SGTC_3191 9110352 49.47 µM 0.866277302517615 0.215646713259914 no 748 0.193169055120069 923 17122424 SGTC_1093 fluphenazine 7.97 µM 0.865936569592588 0.215737716368139 no 749 0.19326247365876 964 6602611 An atypical antipsychotic. SGTC_2720 fluspirilene 36.88 µM 0.862184161953766 0.21674138268445 no 750 0.194293091874106 884 3396 An atypical antipsychotic. SGTC_2438 5259590 200 µM 0.860588519198023 0.217168990336801 no 751 0.194732355673006 1001 1201127 SGTC_2689 tacrolimus 100 µM 0.860471296134768 0.217200423515192 no 752 0.19476464976325 919 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). SGTC_1172 0370-0043 85 µM 0.859962699539101 0.21733683331912 no 753 0.194904802104353 963 376585 SGTC_1134 3477-0009 42.5 µM 0.857906238332518 0.217888897353137 no 754 0.195472119616595 980 3973534 SGTC_820 1582-0060 59.9 µM 0.857656971665691 0.217955868750173 no 755 0.19554095308594 943 3848840 SGTC_1362 1611-0397 101 µM 0.856652636496165 0.218225827417307 no 756 0.195818443213251 966 27816 SGTC_1389 3405-0187 19 µM 0.855473556738041 0.218543002012676 no 757 0.196144518725052 888 799890 SGTC_1325 1431-0015 227 µM 0.853748663758153 0.219007479193895 no 758 0.196622132137827 904 1103340 SGTC_232 clozapine 119 µM 0.852831415483813 0.21925470579815 no 759 0.196876399849085 954 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_1973 st070275 50.2 µM 0.851350058571653 0.219654315556879 no 760 0.197287462611296 959 17118334 SGTC_2831 7999036 19.48 µM 0.851169840596773 0.219702959544847 no 761 0.197337506820825 993 2988270 SGTC_1088 bifonazole 369 nM 0.850903644260837 0.219774821912476 no 762 0.197411440158061 942 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase. SGTC_1165 k072-0275 30.3 µM 0.850821072737501 0.219797115664033 no 763 0.197434376966085 985 6153523 YGL055W OLE1 SGTC_2655 perillic acid 100 µM 0.850422956289065 0.219904622622821 no 764 0.197544988802754 939 5702197 An apoptosis inducer. SGTC_281 1672-3440 14.9 µM 0.847116338847564 0.220798703605175 no 765 0.198465139453053 1019 6833000 SGTC_2774 tamoxifen 10.92 µM 0.846949935428392 0.220843752607118 no 766 0.198511513685735 993 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  SGTC_2671 danthron 100 µM 0.846776151169156 0.220890805379383 no 767 0.198559951829606 964 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin. SGTC_2318 6029776 164 µM 0.846504242693943 0.220964437183257 no 768 0.198635754018986 966 818325 SGTC_3271 9137798 49.47 µM 0.845584520517834 0.221213598631782 no 769 0.198892281949841 900 6498326 SGTC_1668 st014914 51.6 µM 0.843367062997614 0.221814989298898 no 770 0.199511593392157 1001 2839556 SGTC_1414 3917-0015 5.4 µM 0.839577549392201 0.222844891660495 no 771 0.200572645685891 995 6618702 SGTC_3339 9145883 14.936 µM 0.83605439359664 0.223804843368376 no 772 0.2015621517677 929 2030670 SGTC_2307 7538926 6.34 µM 0.831627757806836 0.225014290837413 no 773 0.202809544586812 989 96582 SGTC_2761 levamisole 97.89 µM 0.830438551993542 0.225339836262008 no 774 0.203145438164195 983 26879 An alkaline phosphatase inhibitor. SGTC_2051 5263410 176 µM 0.830263891783692 0.225387671994873 no 775 0.203194799247136 1051 227584 SGTC_3320 9137005 35.139 µM 0.829897008849703 0.225488172181507 no 776 0.203298508102357 916 4908713 SGTC_719 2810-4230 27.3 µM 0.828170360512152 0.225961493154991 no 777 0.203787013457573 995 721079 SGTC_2709 st078560 56 µM 0.827855575754385 0.226047844662686 no 778 0.203876148078749 1011 17250903 SGTC_419 nsc-638432 893 µM 0.827483076016465 0.22615005259043 no 779 0.203981655315221 989 368090 SGTC_2292 7671323 168.05 µM 0.826478291557052 0.226425879450602 no 780 0.204266413759533 979 937504 SGTC_3125 9127534 49.47 µM 0.824536764834058 0.226959392505948 no 781 0.204817317442811 906 1639235 SGTC_428 3448-4153 16.5 µM 0.822436062463458 0.227537443180823 no 782 0.205414380959509 930 3834874 SGTC_3155 9099265 49.47 µM 0.821481865342713 0.22780028336502 no 783 0.205685924761847 926 25236499 SGTC_1881 5652484 16 µM 0.820215606618159 0.22814934675065 no 784 0.20604660329327 974 2255129 SGTC_615 k087-0205 167 µM 0.819576408594338 0.228325665523326 no 785 0.206228813505419 990 9642773 SGTC_2760 etidronate 98.04 µM 0.818924823760842 0.228505479916439 no 786 0.206414652982677 1026 3305 A chelator and antioxidant. SGTC_2735 sertaconazole 140 nM 0.817970815601318 0.228768895910106 no 787 0.206686925988791 1001 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C SGTC_3295 9122362 53.5725 µM 0.816739486706676 0.229109136194858 no 788 0.20703866026436 978 4730473 SGTC_1077 5-fluorocytosine 377 nM 0.81620954353851 0.229255657190198 no 789 0.207190149703957 981 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_1714 st033236 13.627 µM 0.815209154208951 0.229532392340881 no 790 0.207476299408033 1026 2916566 SGTC_1830 st055982 50.3 µM 0.81498367963181 0.229594790635393 no 791 0.207540826024319 986 455313 An antimicrobial agent. SGTC_638 3970-0837 4.09 µM 0.814660501269262 0.229684244244547 no 792 0.207633334319916 997 4118451 YLR208W SEC13 SGTC_708 3448-5400 146 µM 0.814054224204996 0.229852110328793 no 793 0.207806944004572 1038 3462195 SGTC_2404 5161160 200 µM 0.812678993351722 0.23023313894087 no 794 0.208201064114071 1026 2831543 SGTC_478 N-arachidonylglycine 10 µM 0.810639476267489 0.230798868062306 no 795 0.208786369879325 934 5283389 SGTC_1323 1348-1351 11.2 µM 0.809746861025113 0.2310467091654 no 796 0.20904283959717 977 6989654 SGTC_259 usnic acid 108.925 µM 0.808113884088438 0.2315005012918 no 797 0.20951251283965 1060 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_1832 st054113 55 µM 0.808025907829467 0.231524963336864 no 798 0.209537833988816 1023 1251267 SGTC_1941 st076221 61.8 µM 0.807191312547867 0.231757096552944 no 799 0.209778135044935 1055 2828568 SGTC_2572 astragaloside iv 100 µM 0.805454054345852 0.232240710851746 no 800 0.210278854859023 1002 45006101 An anti-inflammatory agent. SGTC_1646 st011709 75.6 µM 0.804200905870158 0.232589908039094 no 801 0.210640477865796 1009 5757843 SGTC_1046 2001-0062 216 µM 0.803569780386428 0.232765885329466 no 802 0.210822740801489 983 739778 SGTC_3056 9094900 49.47 µM 0.803384029442593 0.232817692522363 no 803 0.210876401489292 1014 25236784 SGTC_2798 7813637 45.45 µM 0.80272418141608 0.233001780387361 no 804 0.211067086528562 1004 956368 SGTC_423 5-fluorouracil 457 µM 0.802393444272642 0.233094081575932 no 805 0.211162702041148 981 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_785 1270-0111 65.3 µM 0.801745011916968 0.233275103152423 no 806 0.211350236315759 1065 6741994 SGTC_1189 1431-2119 7.28 µM 0.801572005146859 0.233323414291378 no 807 0.211400288393165 1057 3107275 SGTC_3112 9123419 49.47 µM 0.800760113826382 0.233550204386846 no 808 0.211635266986769 1097 17015854 SGTC_944 3370-0224 231 µM 0.800696687272016 0.233567926824074 no 809 0.211653630415051 1051 4580514 SGTC_2830 7992007 71.43 µM 0.797223700103777 0.234539474977944 no 810 0.212660561996544 984 1952075 SGTC_2394 5221648 200 µM 0.79628843967699 0.234801490234713 no 811 0.212932201642764 1117 788586 SGTC_2182 6325192 200 µM 0.794940378501601 0.235179437049037 no 812 0.213324092340189 997 736248 SGTC_115 0527-0192 112.043 µM 0.792252087899189 0.235934136953161 no 813 0.214106851194123 1086 4233931 SGTC_2078 5212016 200 µM 0.792014968673654 0.236000768852594 no 814 0.214175974142436 1017 1899708 SGTC_1906 st060206 94.7 µM 0.79075284761496 0.236355606740783 no 815 0.214544115195655 1078 5133468 SGTC_3194 9111903 49.47 µM 0.787952489054722 0.237143958834578 no 816 0.215362248487116 1046 17087251 SGTC_1001 4048-4355 44.4 µM 0.785899319846577 0.237722880141634 no 817 0.215963236532986 1032 21824233 SGTC_415 dibenzyl ketone 100 µM 0.784828577316515 0.238025099083692 no 818 0.216277041234509 1045 7593 SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM 0.783831451446584 0.238306728869847 no 819 0.216569508186545 1072 7104 SGTC_2925 9010536 32.5 µM 0.783365914840325 0.238438278227184 no 820 0.216706133022718 1076 2994177 SGTC_2941 9056145 11.23 µM 0.780584224359353 0.239225144490877 no 821 0.217523536598216 994 2119517 SGTC_2915 7971052 15.16 µM 0.780576740078497 0.239227263507061 no 822 0.217525738262258 941 5741558 SGTC_1534 6-azauridine 81.6 µM 0.780393215743157 0.239279227758713 no 823 0.217579729962862 1125 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1 SGTC_1145 3546-0597 10.2 µM 0.778939262132005 0.239691127333543 no 824 0.218007747197867 1041 875334 SGTC_1602 st001878 87.6 µM 0.776847003739508 0.240284534672199 no 825 0.218624520701647 1050 595405 YLR310C CDC25 SGTC_1631 benzylvanillin 81.9 µM 0.774490207131504 0.240953928012473 no 826 0.219320478544819 1055 75506 SGTC_752 1896-0090 130 µM 0.774352779866418 0.240992992306619 no 827 0.219361099819555 1064 772567 SGTC_2412 st077135 33.4 µM 0.774167099177622 0.241045778315157 no 828 0.21941599089147 1061 13258915 SGTC_2110 5483698 200 µM 0.773792722640367 0.241152226607479 no 829 0.219526688372913 1079 2848765 YHR062C RPP1 SGTC_318 1488-0629 67.2 µM 0.773466274381596 0.241245068072858 no 830 0.21962324036374 1034 3662576 SGTC_1884 5633444 25 µM 0.772018747979782 0.241656976659923 no 831 0.220051661804682 1070 5724239 SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM 0.771587898167663 0.241779653116365 no 832 0.220179272073529 1152 5024745 SGTC_567 1080-0542 68.4 µM 0.771478550610602 0.241810793172233 no 833 0.220211665681379 1031 5950415 SGTC_3171 9103192 49.47 µM 0.770323137760536 0.242139965218719 no 834 0.220554117301799 1146 13018434 SGTC_82 0054-0107 293.755 µM 0.768938884424774 0.242534652583188 no 835 0.220964796205571 1083 3104697 SGTC_926 2268-1401 59.4 µM 0.76876009670095 0.242585655103617 no 836 0.221017870669026 1108 2931578 SGTC_520 3584-0023 682 µM 0.768441419018847 0.242676578234555 no 837 0.221112490595547 1014 1340790 SGTC_2589 lobaric acid 100 µM 0.768346340181108 0.242703709109218 no 838 0.221140725340439 1098 73157 A novel microtubule depolymerizer. SGTC_2789 5281112 71.43 µM 0.76742741844985 0.242966009269678 no 839 0.22141371591634 1076 765948 SGTC_1998 st075797 76.8 µM 0.766340860804804 0.243276357760098 no 840 0.22173675575617 1121 24208315 SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM 0.765339048753754 0.243562690499326 no 841 0.22203483868176 1053 17037758 SGTC_2666 tannic acid 100 µM 0.763642457622431 0.244048016250653 no 842 0.222540170187611 1119 16134267 A thiamine antagonist. SGTC_1121 fusaric acid 630.51 nM 0.761320846940921 0.244712979053361 no 843 0.223232725924146 1059 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler. SGTC_872 0588-0139 234 µM 0.761181678394706 0.244752871100127 no 844 0.223274279994748 1137 2047100 SGTC_550 4123-0385 25.7 µM 0.759669022500401 0.245186692944179 no 845 0.223726224919716 1091 5731123 SGTC_1991 st073000 8.92 µM 0.759225300661777 0.245314028448929 no 846 0.22385889684375 1116 4301969 YIL048W NEO1 SGTC_1257 0669-0121 16 µM 0.758735828697861 0.245454534157587 no 847 0.224005299815355 1168 4307855 SGTC_2129 girgensonine 121.053 µM 0.757492212524853 0.245811715663608 no 848 0.224377514831751 1131 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_792 4534-1957 155 µM 0.756862040868291 0.245992814989706 no 849 0.224566259494734 1066 1717904 SGTC_2935 9038016 29.96 µM 0.755537040472511 0.246373828236021 no 850 0.224963408127295 1111 6463195 SGTC_1228 0124-0032 52.5 µM 0.754831027677758 0.246576976312204 no 851 0.225175187143667 1138 X1228 SGTC_3181 9108277 49.47 µM 0.753783341740971 0.24687860269333 no 852 0.225489664138148 1087 17097298 SGTC_476 mead acid 10 µM 0.753344285550074 0.247005064661106 no 853 0.225621526630509 1112 5312531 An omega 9 fatty acid. SGTC_1025 k007-0731 70 µM 0.751068060262588 0.247661244270862 no 854 0.226305848299984 1124 6256118 SGTC_210 3551-0445 56.827 µM 0.750751608572139 0.247752543144685 no 855 0.22640107870473 1121 2865180 YOR207C RET1 SGTC_643 k048-0106 28.4 µM 0.749927427873729 0.247990410273933 no 856 0.226649207155363 1099 6763920 SGTC_918 glabranin 770.725 nM 0.749520980608684 0.248107760036606 no 857 0.226771628955982 1106 124049 Also referred to as licorice root. SGTC_2080 5212524 12.4 µM 0.749057282741761 0.248241675401642 no 858 0.226911340172449 1082 260183 SGTC_420 mitomycin C 81.9 mM 0.748444475235901 0.248418712552629 no 859 0.227096052270721 1096 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_2786 7743617 45.45 µM 0.747946423465145 0.248562646875719 no 860 0.227246237181886 1043 583674 SGTC_212 3807-4682 38.772 µM 0.747781676216189 0.248610267734958 no 861 0.227295928171576 1224 3125501 YBL034C STU1 SGTC_2038 4100038 30.985 µM 0.747605138699127 0.248661302012498 no 862 0.227349182131441 1079 3596803 SGTC_2296 7971656 126.45 µM 0.747136146443927 0.248796907547991 no 863 0.227490691550257 1124 666570 SGTC_1660 st012960 28.1 µM 0.746777031437736 0.248900769524976 no 864 0.227599081143406 1085 24207266 SGTC_2821 7996764 71.43 µM 0.745393839874149 0.249301026845491 no 865 0.228016833382752 1194 2987135 SGTC_3189 9110682 49.47 µM 0.741744071425452 0.250358809382229 no 866 0.229121206158003 1143 17122418 SGTC_1403 3909-7815 62.9 µM 0.741467556073364 0.250439046407204 no 867 0.22920499821487 1084 6615483 SGTC_3331 9141060 1.957 µM 0.740915910790018 0.250599159152823 no 868 0.229372213832859 1119 4906567 YPR165W RHO1 SGTC_3134 9127454 49.47 µM 0.737172276775951 0.251687164454012 no 869 0.230508795155056 1195 24262820 SGTC_943 3253-1379 105 µM 0.733212602015276 0.252840666418162 no 870 0.231714385181845 1105 668464 SGTC_1089 terbinafine 2.25 µM 0.73246504441462 0.253058751017895 no 871 0.231942385368049 1126 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_2165 5727197 32.143 µM 0.732251528551178 0.253121058056579 no 872 0.232007529241904 1234 1361712 SGTC_2732 terfenadine 20 µM 0.730896786684207 0.253516579415435 no 873 0.23242109944107 1137 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.  SGTC_3277 9138724 49.47 µM 0.728186727955209 0.254308763451413 no 874 0.23324964458213 1031 15943418 SGTC_2337 9009472 200 µM 0.728168576014043 0.254314073862254 no 875 0.233255199688807 1143 5742383 SGTC_3269 9137823 49.47 µM 0.727370090436611 0.254547730986411 no 876 0.233499635870316 1086 17682936 SGTC_1711 st032263 62.8 µM 0.72367381736069 0.255630817730998 no 877 0.234633005512445 1138 3958979 SGTC_2736 butenafine 14.65 µM 0.722966001936436 0.255838496958229 no 878 0.234850385946414 1152 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_2920 7982904 15.77 µM 0.72226375619019 0.256044628986315 no 879 0.23506616580913 1103 6456808 SGTC_1324 1418-0026 34.4 µM 0.721312867022435 0.256323883981817 no 880 0.235358521090086 1153 1372513 SGTC_2595 hexamethylquercetagetin 100 µM 0.720749546311384 0.256489393590059 no 881 0.235531811277392 1079 386331 SGTC_760 0568-0725 82.9 µM 0.719820667810637 0.256762429504191 no 882 0.235817708983829 1170 3916171 SGTC_1068 loratadine 26.9 µM 0.717454829566701 0.257458530300214 no 883 0.236546749218743 1144 3957 A H1 histamine antagonist. SGTC_844 0330-0132 15.3 µM 0.71498488681369 0.258186306458581 no 884 0.237309190999757 1178 2828079 SGTC_673 1082-0474 110 µM 0.714655628656924 0.25828340387794 no 885 0.23741093090197 1212 3098046 SGTC_2910 7948405 25.97 µM 0.71284580410256 0.258817454393428 no 886 0.237970589272838 1140 2971328 SGTC_701 4424-0219 185 µM 0.712698678507845 0.258860893922878 no 887 0.238016117200853 1212 2911779 SGTC_2181 6316240 54.2555 µM 0.710505110611783 0.259509002356364 no 888 0.238695481436383 1160 12779990 SGTC_2907 7721985 69.9 µM 0.70959945147219 0.259776831313459 no 889 0.238976279938721 1149 3267881 SGTC_2072 5231554 129 µM 0.708277481117375 0.260168031140047 no 890 0.239386479243885 1245 789545 SGTC_1845 st056753 3.01 µM 0.707744623484387 0.26032580114127 no 891 0.239551930382985 1147 5375839 SGTC_942 3253-1115 227 µM 0.707402182308212 0.260427218107699 no 892 0.239658290567233 1207 46497897 SGTC_1981 st071826 47 µM 0.706652594431511 0.260649286152108 no 893 0.239891198013633 1143 11838600 SGTC_2007 4011539 71.82 µM 0.706208131076416 0.260781005997258 no 894 0.2400293572829 1188 45595301 SGTC_3088 9117578 49.47 µM 0.702114598968516 0.261995761274502 no 895 0.241303849316526 1239 678341 SGTC_1315 1237-0019 3.69 µM 0.70182124540447 0.262082925177375 no 896 0.241395323846067 1186 825140 SGTC_1321 1326-2144 215 µM 0.700913776369824 0.262352654774031 no 897 0.241678413232432 1166 3513030 SGTC_565 1418-0001 44.5 µM 0.699524787597488 0.262765783003557 no 898 0.242112063842453 1209 2862145 SGTC_1415 3966-0071 78.1 µM 0.699481596045952 0.262778634839568 no 899 0.242125555263681 1179 2893185 SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM 0.699199090519143 0.26286270352874 no 900 0.242213809449102 1186 5379071 SGTC_991 3996-0057 64.7 µM 0.698914057779738 0.262947538207824 no 901 0.242302870799886 1156 715343 SGTC_1901 st060216 58.6 µM 0.697677666098367 0.263315689099057 no 902 0.242689399205921 1202 688792 SGTC_3217 9129673 49.47 µM 0.696280186928126 0.263732122438561 no 903 0.243126689346856 1195 17248312 SGTC_1011 4112-3381 17.4 µM 0.695230000015638 0.264045287432665 no 904 0.24345558722679 1240 2877139 SGTC_3062 9077494 49.47 µM 0.694921811666163 0.264137224928853 no 905 0.2435521513549 1157 16459633 SGTC_2791 5663188 71.43 µM 0.694837555599842 0.264162362694404 no 906 0.243578554764406 1175 54690634 SGTC_2621 lithochol-11-enic acid 100 µM 0.692236093085168 0.264939107239803 no 907 0.244394537933458 1198 6708711 SGTC_670 4204-0025 119 µM 0.689979388805564 0.265613852755898 no 908 0.245103574532413 1209 719039 SGTC_524 r073-0010 27.8 µM 0.68431188422972 0.267312247903943 no 909 0.246889122063423 1155 2772106 SGTC_1882 5615643 20 µM 0.683941566056308 0.267423412480188 no 910 0.24700603264002 1154 2253075 SGTC_2814 7977482 42.97 µM 0.683923270184527 0.267428905261254 no 911 0.247011809470308 1244 6456762 SGTC_1971 st069429 63.5 µM 0.683183707651619 0.267650984128283 no 912 0.24724538315844 1207 1246522 YGL099W LSG1 SGTC_2391 6285546 200 µM 0.682607567719167 0.267824054176339 no 913 0.247427425408424 1197 846083 SGTC_664 1222-0054 14.9 µM 0.681829099517022 0.268057992315078 no 914 0.24767351081856 1220 6813991 SGTC_1055 3448-0672 86 µM 0.68079788496586 0.268368041775872 no 915 0.247999694273443 1195 748378 SGTC_2622 2-methoxyxanthone 59.94 µM 0.679677067153825 0.268705236168386 no 916 0.248354479926851 1238 71034 A hepatoprotective. SGTC_984 1492-0255 2.91 µM 0.679121107809861 0.268872573670651 no 917 0.248530564616244 1166 1585198 SGTC_1876 myriocin 605 nM 0.678316241129651 0.269114922158838 no 918 0.248785601603259 1247 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1 SGTC_2693 st077581 40.7 µM 0.677017304360677 0.26950626811975 no 919 0.249197487614831 1247 25238761 SGTC_288 1315-0019 35.1 µM 0.676046603487551 0.269798908687693 no 920 0.249505528359886 1257 6811474 SGTC_999 SEC7.066 22.7 µM 0.674966871882042 0.270124605943511 no 921 0.249848406305406 1240 740511 YDR170C SEC7 SGTC_2504 purpurogallin 52.29 µM 0.674688974503167 0.270208464526872 no 922 0.249936695436281 1190 5281571 An antioxidant. SGTC_2290 7904846 200 µM 0.674490759476595 0.27026828603983 no 923 0.249999679274407 1250 2962154 SGTC_369 0957-0393 4.5 µM 0.674193595121801 0.270357982972655 no 924 0.250094120543256 1214 6997992 SGTC_3080 9117754 49.47 µM 0.674179355451875 0.270362281488641 no 925 0.25009864650227 1284 9550191 SGTC_2167 5876490 200 µM 0.673507885747074 0.270565016205187 no 926 0.250312116808747 1274 686534 SGTC_1533 dihydroergotamine mesylate 29.4 µM 0.673153682976225 0.270671990110601 no 927 0.250424762096992 1281 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release. SGTC_183 3914-0051 30.55 µM 0.669193507274393 0.271869451632582 no 928 0.251686023714486 1227 1596232 SGTC_1476 4112-3294 3.34 µM 0.669041087589072 0.271915592285308 no 929 0.251734634250172 1270 704369 SGTC_2258 7960471 200 µM 0.668616341367097 0.272044192472509 no 930 0.251870122836604 1186 2974708 SGTC_938 3126-1755 342 µM 0.666403186609678 0.272714757099117 no 931 0.252576713117294 1259 1777771 SGTC_1222 0366-0074 1.18 µM 0.666362466723763 0.272727102513137 no 932 0.252589723464782 1268 286520 SGTC_2472 5377652 49.4 µM 0.665191096449342 0.273082356051899 no 933 0.252964137260228 1235 1610903 SGTC_325 2810-4341 181 µM 0.663519740156607 0.273589642280245 no 934 0.253498870533526 1243 774970 SGTC_2603 homopterocarpin 100 µM 0.662629109630454 0.273860154739054 no 935 0.25378406100273 1262 101795 A weak amylase inhibitor. SGTC_1740 st038286 13.222 µM 0.660393260005699 0.274539834645917 no 936 0.254500748147359 1272 716786 SGTC_2515 chrysin 20.77 µM 0.660161915661299 0.274610208907813 no 937 0.254574964572445 1244 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor. SGTC_608 k048-0125 159 µM 0.659565969994564 0.274791534782046 no 938 0.254766199134206 1268 6817652 YLR060W | YFL022C FRS1 | FRS2 SGTC_3199 9111318 49.47 µM 0.659224992099778 0.274895309228198 no 939 0.254875650238604 1217 8548020 SGTC_1154 4088-0362 150 µM 0.658691387140091 0.275057747243782 no 940 0.255046982428255 1266 6618304 SGTC_2586 curcumin 80 µM 0.65723834627698 0.275500315997091 no 941 0.255513836309433 1268 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40 SGTC_3094 9117742 49.47 µM 0.657089377997283 0.275545708703971 no 942 0.25556172420119 1221 17149698 SGTC_1477 0139-0234 16 µM 0.656372125843627 0.275764316887521 no 943 0.255792360330744 1260 620880 SGTC_2399 5884133 200 µM 0.656361886189256 0.275767438404523 no 944 0.255795653730889 1262 722445 SGTC_1561 5-methoxyflavone 52.9 µM 0.654543117535197 0.276322157933675 no 945 0.256380978810465 1224 94525 SGTC_2440 5628896 157.78 µM 0.654501040121766 0.276334997907121 no 946 0.256394528626758 1278 5522048 SGTC_230 MPP+ 141.667 µM 0.653594943749318 0.276611565299545 no 947 0.256686401321732 1226 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death. SGTC_36 0335-0881 14.2 µM 0.652052014410677 0.277082824913882 no 948 0.257183809124812 1222 23828853 SGTC_3322 9139058 2.11 µM 0.651017290777567 0.277399082321444 no 949 0.257517662662955 1311 4908926 YPR165W RHO1 SGTC_3190 9110366 49.47 µM 0.648590441624482 0.278141526619079 no 950 0.258301567665583 1197 17123768 SGTC_299 1273-0059 1.44 µM 0.647516626795502 0.278470347061951 no 951 0.258648818573088 1228 2848077 SGTC_90 0870-0863 4.608 µM 0.645521036050838 0.279081933619136 no 952 0.2592947952948 1258 1738164 SGTC_2362 9071156 126 µM 0.644887353705161 0.279276274103306 no 953 0.25950009379679 1296 653133 SGTC_1681 tripelennamine 100 µM 0.644731718515649 0.279324015043923 no 954 0.259550528855225 1273 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist. SGTC_3260 9137109 49.47 µM 0.644303811119346 0.279455295649503 no 955 0.259689222387632 1164 17478346 SGTC_1350 1495-0454 146 µM 0.642746458887879 0.279933339108082 no 956 0.260194314836 1310 1069057 SGTC_2466 5983409 37.09 µM 0.642244218626118 0.280087590850283 no 957 0.26035731316427 1281 2879657 SGTC_458 nppb 133 µM 0.641388196091754 0.28035059372374 no 958 0.260635250069357 1343 4549 A chloride channel blocker. SGTC_1254 0550-0035 264 µM 0.641309797696172 0.280374686686892 no 959 0.260660712413523 1312 15121435 SGTC_28 pentachloropyridine N-oxide 1.606 µM 0.64078909610093 0.280534731270674 no 960 0.260829859113784 1249 140250 A respiratory chain inhibitor. SGTC_1187 1391-0724 117 µM 0.64013700038104 0.280735223926594 no 961 0.261041767991263 1305 6997986 SGTC_2012 4023501 200 µM 0.639627048298135 0.28089206152309 no 962 0.261207546684245 1253 3477460 SGTC_2826 7992541 19.48 µM 0.639007908613417 0.281082537069282 no 963 0.261408893515031 1342 2985066 SGTC_1004 4084-0029 199 µM 0.638931210361684 0.281106137285253 no 964 0.261433841656576 1300 716894 YLR208W SEC13 SGTC_1164 k060-0068 93.7 µM 0.638690803573067 0.281180117169411 no 965 0.26151204826535 1310 5963676 SGTC_2652 actinonin 100 µM 0.638301543118255 0.281299923418523 no 966 0.261638703847462 1265 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase. SGTC_2754 granisetron 64.02 µM 0.631564798697592 0.283377247022223 no 967 0.26383564730525 1313 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients. SGTC_1301 naphtanilide LB 4.81 µM 0.630449121961139 0.28372198256452 no 968 0.264200390300108 1342 67238 An a1-adrenergic receptor antagonist or alpha blocker. SGTC_3337 9144342 33.5465 µM 0.629503290987549 0.284014394285907 no 969 0.264509807433313 1328 17682949 SGTC_464 bw-b 70c 158 µM 0.628688360083776 0.28426645270963 no 970 0.264776549993769 1324 5353454 SGTC_978 1416-0512 87.4 µM 0.628433968496338 0.284345158014798 no 971 0.26485984525497 1329 6814003 SGTC_2575 plumbagin 510 nM 0.626239604632513 0.285024496411226 no 972 0.265578896836117 1266 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_1717 st033143 58.0435 µM 0.626028995658621 0.285089738112528 no 973 0.26564796145657 1352 674616 SGTC_3227 9130768 49.47 µM 0.624668907911508 0.285511232618429 no 974 0.266094191789696 1330 17720899 SGTC_1640 st009078 66.4 µM 0.623739734369403 0.285799356217592 no 975 0.266399261849413 1338 690618 SGTC_2908 7930301 100 µM 0.623091908921812 0.286000319523155 no 976 0.266612063199498 1246 2223178 SGTC_1220 1838-0075 193 µM 0.622760964213359 0.28610300849388 no 977 0.2667208069399 1237 5529645 SGTC_2580 diallyl disulphide 81.36 µM 0.622735912981287 0.286110782364182 no 978 0.26672903933233 1323 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.  SGTC_3300 9124615 50.48 µM 0.621383753561084 0.286530531776896 no 979 0.267173579477408 1368 24824903 SGTC_2186 6124449 200 µM 0.620631585189736 0.286764152993527 no 980 0.267421026469711 1294 3834182 YLR033W RSC58 SGTC_1148 3909-7663 27.7 µM 0.620314079903853 0.286862796268276 no 981 0.267525513469831 1369 4084526 SGTC_987 1497-1013 404 µM 0.619792521722651 0.287024870059829 no 982 0.267697196382635 1302 1676435 SGTC_3006 9075424 71.4286 µM 0.6187958340957 0.287334710520608 no 983 0.268025433481542 1275 7465181 SGTC_1031 k035-0009 16 µM 0.618518647695557 0.287420907622085 no 984 0.268116754710432 1325 5180959 SGTC_1307 1187-1599 12.2 µM 0.618162518310355 0.287531671698823 no 985 0.268234107304992 1301 1538471 SGTC_776 4476-4378 112 µM 0.618104586323307 0.287549691730158 no 986 0.268253199633543 1304 2892008 SGTC_76 0433-0009 400.328 µM 0.616938589348763 0.287912494329055 no 987 0.268637616190433 1322 2841569 SGTC_337 1315-0038 354 µM 0.616814927340054 0.287950984717088 no 988 0.268678402444182 1309 1626437 SGTC_1575 cyproterone acetate 48 µM 0.613949247750027 0.288843620832959 no 989 0.269624432653787 1271 9880 An androgen receptor antagonist and liver toxin. SGTC_3005 9076496 71.4286 µM 0.613457583487162 0.288996901096804 no 990 0.269786910491693 1337 21368410 SGTC_383 2324-0395 7.37 µM 0.612843451269597 0.289188415458275 no 991 0.26998992854782 1352 3146421 SGTC_459 nigericin 15.3 µM 0.611966787465402 0.289461902443129 no 992 0.270279865937783 1367 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification. SGTC_2375 9072683 200 µM 0.611933708218611 0.289472224334049 no 993 0.270290809222654 1377 16798029 SGTC_1860 st056228 74.6 µM 0.610142868992837 0.290031287133928 no 994 0.270883585537319 1294 688679 SGTC_897 1000-0139 31.4 µM 0.608891262165537 0.290422313024655 no 995 0.271298258167418 1328 6151020 SGTC_1153 4055-0057 267 µM 0.60850642104672 0.290542594334705 no 996 0.271425824297027 1304 882706 SGTC_571 k831-0106 44.2 µM 0.608437681235725 0.290564081276555 no 997 0.271448613135376 1361 4783639 SGTC_2048 5246248 200 µM 0.607940754422983 0.290719434591277 no 998 0.271613384221724 1319 677046 SGTC_3168 9103419 49.47 µM 0.606788883257799 0.291079691252115 no 999 0.271995513287301 1287 16649256 SGTC_16 erodoxin 22.806 µM 0.605202411931023 0.291576213578004 no 1000 0.272522256715031 1354 3967339 Erodoxin inhibits Ero1. YML130C ERO1 SGTC_2713 st079149 53.4 µM 0.605126193481613 0.291600077816273 no 1001 0.272547575664383 1352 3103253 SGTC_361 000s-0510 1.45 µM 0.604385186770817 0.291832136817381 no 1002 0.272793790977964 1337 660 SGTC_367 0335-0881 7.1 µM 0.60394297229593 0.291970664867243 no 1003 0.272940778742051 1342 23828853 SGTC_1234 0326-0494 15.5 µM 0.601143250998524 0.292848414947734 no 1004 0.273872289102809 1401 1547813 SGTC_959 1222-0044 107 µM 0.599174697841432 0.293466315195949 no 1005 0.274528196804285 1335 6083612 SGTC_1949 st076024 69.1 µM 0.594202790498739 0.295029607230621 no 1006 0.27618824330169 1316 2921930 SGTC_2885 9057732 51.95 µM 0.593906436204671 0.295122909455107 no 1007 0.27628734699415 1336 6471414 SGTC_1917 st066507 28.5 µM 0.59358131444159 0.295225284266428 no 1008 0.276396090868113 1358 3156428 SGTC_2184 6075246 200 µM 0.592243076026677 0.295646842740328 no 1009 0.276843914015921 1376 2267320 SGTC_2044 5102272 200 µM 0.591892269267398 0.295757396129148 no 1010 0.276961365450742 1341 592666 SGTC_1834 st055981 52.8 µM 0.591285656848253 0.295948609026083 no 1011 0.277164519138395 1426 471719 YDL150W RPC53 SGTC_1137 ixabepilone 100 µM 0.590886474258558 0.296074468035827 no 1012 0.277298244616076 1341 154225 A novel microtubule stabilizer. SGTC_641 4092-0595 30 µM 0.590163751232162 0.296302399177106 no 1013 0.277540435830798 1368 786260 SGTC_3241 9133421 49.47 µM 0.588046926534061 0.296970462228349 no 1014 0.278250397694634 1365 17018221 SGTC_3160 9100216 49.47 µM 0.587369813371741 0.297184302325474 no 1015 0.278477681459387 1313 17191039 SGTC_2441 5730946 39.09 µM 0.585810216462043 0.297677108471913 no 1016 0.279001528719322 1410 1774275 SGTC_2881 9058953 51.95 µM 0.584026664522472 0.298241137206281 no 1017 0.279601186253104 1302 17122249 SGTC_1558 st069300 45.6 µM 0.583674717858448 0.298352493943616 no 1018 0.279719589990767 1362 24208000 SGTC_740 k014-0057 261 µM 0.579368553628667 0.299716503842309 no 1019 0.281170258929339 1434 4012779 SGTC_600 1495-0418 41.6 µM 0.578682046969241 0.299934220775419 no 1020 0.28140186598967 1370 5377768 SGTC_1730 st033808 45.1 µM 0.576775668261576 0.300539179762793 no 1021 0.28204550421497 1432 1045166 SGTC_370 0180-0345 38.7 µM 0.573442944612203 0.301598088012865 no 1022 0.283172410054951 1353 3989527 SGTC_2024 5144227 134 µM 0.57279554930135 0.301803979818619 no 1023 0.28339156647417 1396 3475211 SGTC_707 0865-0008 204 µM 0.571664443571269 0.302163858080576 no 1024 0.283774663696814 1439 723043 SGTC_2919 7978188 46.38 µM 0.569620454302197 0.302814671980894 no 1025 0.284467576141306 1389 2980291 SGTC_2904 7225135 42.03 µM 0.569414318243862 0.302880341309842 no 1026 0.284537501115294 1442 4446116 SGTC_2482 5981709 142.65 µM 0.567970505539803 0.303340479277637 no 1027 0.285027497730367 1405 877755 SGTC_1946 st076057 65.1 µM 0.566683844469433 0.303750796633712 no 1028 0.285464499472908 1295 953009 SGTC_2356 9061756 188.97 µM 0.566103141905043 0.303936064273915 no 1029 0.285661833793873 1386 20104043 SGTC_1269 0831-0796 3.05 µM 0.564484549112303 0.304452726691447 no 1030 0.2862122062439 1421 927758 SGTC_922 1866-0035 480 µM 0.562159732601584 0.305195502092076 no 1031 0.287003596954267 1448 3156169 SGTC_1550 gossypolone 36.6 µM 0.561707028109857 0.305340234004238 no 1032 0.287157822555801 1378 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_2255 7941087 197.44 µM 0.561239769255864 0.305489650939451 no 1033 0.287317047614859 1483 935561 SGTC_2730 imipramine 71.33 µM 0.560064441971906 0.305865632522508 no 1034 0.287717741582467 1419 3696 A tricyclic antidepressant. SGTC_2074 5212007 75.395 µM 0.559578007432969 0.306021300519541 no 1035 0.287883654639058 1363 758611 SGTC_1528 arabinosylhypoxanthine 74.6 µM 0.559068495932758 0.306184391142791 no 1036 0.288057487215805 1438 804 An inhibitor of viral and cellular DNA polymerases. SGTC_506 n9-isopropylolomoucine 153 µM 0.55880253401723 0.30626953872292 no 1037 0.288148246441964 1446 6610355 SGTC_1311 1190-0148 100 µM 0.55847911659435 0.306373094755703 no 1038 0.288258630475292 1462 1961333 SGTC_3208 9114115 49.47 µM 0.557754872298938 0.306605048885459 no 1039 0.288505891095296 1333 650895 SGTC_1492 4158-0558 28.5 µM 0.55749567569585 0.306688080760686 no 1040 0.288594406389309 1475 3967268 SGTC_113 0099-0221 2.5 µM 0.556551796977616 0.306990529735459 no 1041 0.28891684778509 1481 89219 SGTC_1594 piperine 70.1 µM 0.556422478975737 0.307031977604 no 1042 0.288961037717991 1365 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM 0.555044560022066 0.30747376911501 no 1043 0.289432090982217 1445 364106 SGTC_52 0329-0193 875 nM 0.554579964838121 0.307622791706412 no 1044 0.289590998056287 1476 3739292 SGTC_2300 7976697 71.57 µM 0.554116602078374 0.307771450613096 no 1045 0.289749524385843 1337 2236109 SGTC_262 fenpropimorph 62.5 µM 0.553865402604724 0.307852055177026 no 1046 0.289835482126595 1357 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_2841 9004761 38.96 µM 0.55310811630852 0.308095108333151 no 1047 0.290094689661559 1308 2991039 SGTC_430 0958-0115 16.4 µM 0.551267287300681 0.308686278445181 no 1048 0.290725229939887 1426 6833180 SGTC_2390 9097792 176.6 µM 0.550556563353827 0.308914655606379 no 1049 0.290968846026684 1365 4497149 SGTC_985 1493-0307 8.71 µM 0.550466057726413 0.308943743115435 no 1050 0.290999875643985 1400 3278274 SGTC_1612 st002233 45.4 µM 0.54969338313995 0.309192120958385 no 1051 0.291264848021606 1430 1035021 SGTC_109 0132-0036 33.701 µM 0.54912652910617 0.309374392840462 no 1052 0.291459310190955 1320 67274 A color developer. SGTC_1339 1486-1321 22.7 µM 0.544683310930014 0.310804731603431 no 1053 0.292985672491028 1412 3469382 SGTC_381 3461-2219 42.7 µM 0.543478642566889 0.311193026859494 no 1054 0.293400145957968 1463 2883159 SGTC_2552 juarezic acid 87.02 µM 0.542531824498859 0.311498357972927 no 1055 0.293726095000974 1434 1549512 SGTC_1889 st059080 5.18 µM 0.540793297195219 0.31205933807957 no 1056 0.294325031672886 1495 176925 Isolated from Daphnopsis sellowiana. SGTC_2076 5212012 200 µM 0.540419149158413 0.312180123545908 no 1057 0.294454002400106 1370 604802 SGTC_698 k064-0052 127 µM 0.539848742339432 0.312364305697748 no 1058 0.29465067470982 1489 5088751 SGTC_533 1222-0222 6.71 µM 0.538444242657335 0.31281801300644 no 1059 0.295135194539442 1522 3982874 SGTC_2608 thymoquinone 42.66 µM 0.537967059696884 0.312972226023365 no 1060 0.295299895057198 1348 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC). SGTC_2304 7443016 91.4 µM 0.536897115870026 0.313318122739177 no 1061 0.295669341666758 1400 939854 SGTC_569 4130-2812 160 µM 0.536197519400773 0.313544380586337 no 1062 0.295911023865932 1404 743552 SGTC_1798 st045719 60.953 µM 0.535735383680042 0.313693879285316 no 1063 0.296070722748419 1374 3980186 SGTC_60 0986-0278 202 µM 0.535656136080996 0.313719518579356 no 1064 0.296098112080826 1251 3110598 SGTC_1684 st024538 14.6195 µM 0.534920779533405 0.313957474332616 no 1065 0.296352319377942 1431 6732859 SGTC_513 4245-1575 41.7 µM 0.534914094915515 0.313959637778888 no 1066 0.296354630659561 1461 719745 SGTC_75 0159-0059 199.013 µM 0.533553934903487 0.314399980343622 no 1067 0.296825093062963 1535 5377270 SGTC_179 1273-0063 6.77 µM 0.533477390296183 0.314424768998793 no 1068 0.296851579046195 1400 3108139 SGTC_441 propafenone 146 µM 0.53287220006201 0.314620786812015 no 1069 0.297061025186618 1401 4932 Slows the influx of sodium ions into the cardiac muscle. SGTC_1995 st072814 61.1 µM 0.532739662752658 0.314663721900418 no 1070 0.297106903134889 1387 5769371 SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM 0.532394692676112 0.314775485734775 no 1071 0.297226330127297 1464 5393153 SGTC_2254 7938975 95.19 µM 0.530437240120205 0.31540998471565 no 1072 0.297904405925224 1517 2969277 SGTC_715 0868-0130 184 µM 0.530245629453924 0.315472123705926 no 1073 0.297970819135092 1578 2876258 SGTC_1461 k072-0203 53.8 µM 0.528795455661664 0.315942581537358 no 1074 0.298473675255476 1368 5418714 SGTC_2469 5655019 90.81 µM 0.528136599114523 0.316156422935192 no 1075 0.298702265050889 1544 2788239 SGTC_1168 k815-0004 80.5 µM 0.527651884177599 0.316313783438658 no 1076 0.298870487339914 1404 642433 SGTC_3070 9117005 49.47 µM 0.527069396209484 0.316502929523807 no 1077 0.299072699079425 1508 8779016 SGTC_1864 st057645 30.4 µM 0.526257286116471 0.31676671884949 no 1078 0.299354728169799 1453 688666 SGTC_3051 9093778 49.47 µM 0.525348002553878 0.317062182618086 no 1079 0.29967064665657 1447 17217378 SGTC_395 anisomycin 6.25 µM 0.524635747435909 0.317293705214149 no 1080 0.299918215667718 1416 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_1930 st074634 34.3 µM 0.524534608720382 0.317326586731993 no 1081 0.299953377446324 1399 684253 YOR116C RPO31 SGTC_1285 0929-0069 65.5 µM 0.524411199740736 0.317366710556647 no 1082 0.299996284208077 1462 1206237 SGTC_2858 9025781 8.96 µM 0.524331814803296 0.317392522027701 no 1083 0.300023886184322 1462 4894980 YPL153C RAD53 SGTC_2946 9065502 71.43 µM 0.52190134039151 0.318183203495753 no 1084 0.300869512504073 1339 16489101 SGTC_1371 2421-0008 32.7 µM 0.518816618046139 0.319187918690545 no 1085 0.301944314114224 1474 2827552 SGTC_468 gf-109203x 121 µM 0.517069342035614 0.319757608794434 no 1086 0.302553877047313 1432 2396 A protein kinase C inhibitor. SGTC_1915 st067105 30.6 µM 0.516720556470036 0.31987137946863 no 1087 0.302675622033133 1407 69751 YOR207C | YOR116C RET1 | RPO31 SGTC_1980 st071811 45.7 µM 0.516282888171555 0.320014166854559 no 1088 0.302828422932165 1501 4974850 SGTC_1937 st074714 47.2 µM 0.515892183342709 0.320141655140728 no 1089 0.302964856887154 1410 17250970 SGTC_852 0418-0143 439 µM 0.515525621459714 0.320261284813822 no 1090 0.303092885142226 1474 5369229 SGTC_37 0566-0070 1.56 µM 0.511962841546979 0.321424991185462 no 1091 0.304338507915441 1541 1626686 SGTC_895 0964-0006 13.7 µM 0.510924014245344 0.32176463302493 no 1092 0.304702132511144 1440 6738897 SGTC_1862 st057513 3.81 µM 0.508875443513935 0.322434844215703 no 1093 0.305419766802249 1454 5393163 SGTC_2134 5324836 1.464 µM 0.507363863147018 0.322929743867189 no 1094 0.305949768170545 1522 699272 SGTC_3209 9113616 49.47 µM 0.505896787168589 0.323410372558574 no 1095 0.306464553936385 1606 16649353 SGTC_723 4182-0001 115 µM 0.505527674440363 0.323531344012582 no 1096 0.306594132987252 1426 744821 YLR208W SEC13 SGTC_941 3237-0776 460 µM 0.503220902864833 0.324287777759549 no 1097 0.307404485075106 1557 760008 SGTC_915 methyl methanesulfonate (MMS) 110 mM 0.502282114500742 0.324595832075545 no 1098 0.307734544254232 1511 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks. SGTC_1805 st050013 60.3 µM 0.50227588584665 0.324597876349184 no 1099 0.307736734644303 1512 4037144 SGTC_2566 crystal violet carbinol 226 nM 0.50189162567804 0.324724002565224 no 1100 0.307871878155389 1380 68050 Cationic dye that binds acidic phospholipids including cardiolipin. SGTC_2692 st077426 47.7 µM 0.500707088514473 0.325112931170643 no 1101 0.308288641398533 1532 25238571 SGTC_1396 3511-0007 98.6 µM 0.499982680673884 0.325350875784937 no 1102 0.308543636286597 1449 X1396 SGTC_3031 9088762 49.47 µM 0.499620425583496 0.325469891616457 no 1103 0.308671186395664 1429 205253 SGTC_1309 pyrazolanthrone 13.4 µM 0.499397601923097 0.325543107278413 no 1104 0.30874965413182 1576 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14 SGTC_1604 st002052 72.4 µM 0.49846000863891 0.325851256518902 no 1105 0.309079924864093 1498 6254834 YHR062C RPP1 SGTC_791 1348-1292 225 µM 0.497688510223413 0.326104906311518 no 1106 0.309351803855345 1507 5437054 SGTC_1687 st020778 55.3625 µM 0.496940594922122 0.326350879381752 no 1107 0.309615471741749 1499 4259299 SGTC_2148 5546263 113.568 µM 0.496736848001286 0.326417900407856 no 1108 0.309687317081345 1497 792097 SGTC_2146 5545642 200 µM 0.494818444754453 0.327049219368651 no 1109 0.310364141637629 1478 825326 SGTC_1292 0kpi-0043 232 µM 0.494595052238232 0.327122766864375 no 1110 0.31044299772153 1471 3333905 SGTC_2136 5328288 199.296 µM 0.493985016978551 0.32732364290509 no 1111 0.310658380518101 1455 262395 SGTC_1180 1193-0155 285 µM 0.491570804527599 0.328119099314962 no 1112 0.311511393403955 1475 2921347 SGTC_2047 4141938 200 µM 0.490436045895691 0.328493259540439 no 1113 0.311912687470862 1510 3807862 SGTC_2526 patulin 37.61 µM 0.49027102845501 0.328547684535226 no 1114 0.311971062565642 1543 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.  SGTC_1891 st059073 26.2 µM 0.484953015505676 0.330303579561511 no 1115 0.31385483721177 1642 688754 SGTC_1812 st052057 4.327 µM 0.482820152961904 0.331008859487053 no 1116 0.314611720058971 1460 3645418 SGTC_1462 k081-0014 26.5 µM 0.482654188353246 0.331063764687953 no 1117 0.314670648181719 1372 3270634 SGTC_3058 9093861 49.47 µM 0.482324163586165 0.331172955844583 no 1118 0.314787842250038 1530 17217477 SGTC_2738 aclarubicin 5.55 µM 0.482224536914359 0.331205920894024 no 1119 0.314823224033987 1530 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31 SGTC_811 0416-0114 265 µM 0.477304289016405 0.332835584240551 no 1120 0.316572728629001 1516 6612453 SGTC_2269 7935389 174.42 µM 0.476626131749214 0.333060449286008 no 1121 0.316814185957667 1450 97605 SGTC_1992 st073643 23.3 µM 0.476467359817864 0.333113103947704 no 1122 0.316870727851321 1529 3161292 SGTC_1036 k216-0215 33.5 µM 0.476070465085731 0.333244743352575 no 1123 0.317012088795947 1488 622330 SGTC_294 k038-0071 157 µM 0.475903452526317 0.333300143109895 no 1124 0.317071581202835 1522 24152826 SGTC_2675 theaflavin digallate 100 µM 0.474951854580564 0.333615867150465 no 1125 0.317410645016447 1532 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative. SGTC_1494 4358-1428 177 µM 0.474049140654699 0.333915481255259 no 1126 0.317732432641511 1635 1564571 SGTC_887 0885-0007 9.62 µM 0.473986663602147 0.333936221541678 no 1127 0.317754708740535 1591 5719458 SGTC_2395 5646831 180.19 µM 0.472865986831902 0.334308334753246 no 1128 0.318154396333527 1577 6808628 SGTC_2401 5128683 200 µM 0.472727067876322 0.334354473215747 no 1129 0.318203956325646 1430 708373 SGTC_2179 6298986 200 µM 0.471589796480678 0.334732283559959 no 1130 0.318609805578452 1631 738374 SGTC_1769 st044406 64.4 µM 0.471570411042201 0.334738725004218 no 1131 0.318616725398467 1528 670903 SGTC_2574 2',4'-dihydroxychalcone 14.64 µM 0.470967420098659 0.33493911268853 no 1132 0.318832000432189 1619 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_599 1935-0052 86.5 µM 0.4695769525214 0.335401375952053 no 1133 0.319328647076267 1501 9557311 SGTC_826 1683-5028 118 µM 0.467669271009616 0.336035993417374 no 1134 0.320010559646543 1538 722377 SGTC_911 3456-4043 236 µM 0.466018391599169 0.336585559583837 no 1135 0.320601168049781 1626 914281 SGTC_570 0987-0065 62.6 µM 0.465797114067242 0.336659247887243 no 1136 0.320680365504614 1506 3104428 SGTC_814 3342-0569 96 µM 0.464712946279929 0.337020380501075 no 1137 0.321068517988543 1549 4346283 SGTC_2414 st077232 92.9 µM 0.461731192757898 0.338014366620628 no 1138 0.322137049611143 1467 729801 SGTC_379 3970-0972 5.9 µM 0.459619716654116 0.338718924500326 no 1139 0.32289460218568 1566 2898042 YBL034C STU1 SGTC_804 1595-0054 20.9 µM 0.45817682938928 0.339200712473076 no 1140 0.323412702570203 1517 761523 Stimulates phospholipase C. SGTC_2926 9010726 65.15 µM 0.458148729478702 0.33921009780098 no 1141 0.323422795864724 1492 2994293 SGTC_286 k060-0067 22.9 µM 0.45772050659381 0.339353135942554 no 1142 0.323576626653278 1522 5985051 SGTC_357 1325-0123 420 µM 0.457653506418777 0.339375517926214 no 1143 0.323600697898901 1602 1098503 SGTC_1942 st076330 65.2 µM 0.457613728004057 0.339388806515235 no 1144 0.323614989494218 1553 24208414 SGTC_229 benomyl 22.8748 µM 0.457460040009218 0.339440150221498 no 1145 0.323670208986149 1519 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C SGTC_2372 9071633 200 µM 0.456479729041895 0.339767720196112 no 1146 0.324022522178978 1580 21321366 SGTC_466 geldanamycin 89.2 µM 0.45608134570887 0.339900874211321 no 1147 0.324165741932303 1557 5288382 HSP90 inhibitor. SGTC_1775 st081588 35.1725 µM 0.454222892648644 0.3405222996858 no 1148 0.324834203804137 1535 1426443 YGL099W LSG1 SGTC_626 0214-0009 33 µM 0.453657896260576 0.340711307891098 no 1149 0.32503753778513 1642 3437874 SGTC_3122 9126309 49.47 µM 0.453252494646975 0.340846951517664 no 1150 0.32518346804982 1569 17591206 SGTC_3313 9133968 57.047 µM 0.451925708753575 0.341291025599999 no 1151 0.325661251518732 1528 1494643 SGTC_346 4513-0042 7.16 µM 0.451842292802029 0.341318952198624 no 1152 0.325691299679341 1529 2827372 SGTC_2987 9018338 71.43 µM 0.45174029926261 0.341353099518006 no 1153 0.325728041412457 1562 5055682 SGTC_1739 st037196 92.5 µM 0.450952370543455 0.341616940903355 no 1154 0.326011938645451 1680 612214 SGTC_2344 7990960 76.95 µM 0.450266600295203 0.341846637083953 no 1155 0.326259109459767 1561 140813 SGTC_1272 0839-0021 27 µM 0.450188918377774 0.341872660045643 no 1156 0.326287113014485 1558 5027250 SGTC_72 0744-0168 198.391 µM 0.448794448782596 0.342339926422969 no 1157 0.326789971816394 1609 677577 SGTC_87 0100-0052 35.5 µM 0.448644517210557 0.342390180689498 no 1158 0.326844057303127 1616 200187 YGR083C | YDR527W GCD2 | RBA50 SGTC_871 0574-0004 149 µM 0.448412617458053 0.342467914657336 no 1159 0.326927718703452 1559 9551173 SGTC_3309 9129340 25.759 µM 0.448363145673627 0.342484498713014 no 1160 0.326945567536238 1615 17158987 SGTC_1700 st030840 7.9285 µM 0.448186117041376 0.342543845182616 no 1161 0.32700944060905 1659 5499307 SGTC_1585 2',4'-dihydroxychalcone 10.4 µM 0.4481248821668 0.342564374256215 no 1162 0.327031535726715 1646 5357218 A potent inhibitor of glutathione S-transferases. SGTC_1969 st069479 40.1 µM 0.446077866842096 0.343250906168357 no 1163 0.327770500003333 1632 3895485 SGTC_2302 7771753 200 µM 0.44487973676938 0.343652977630572 no 1164 0.32820333348498 1504 2203047 SGTC_1053 3366-3204 134 µM 0.444320796058677 0.34384060889492 no 1165 0.328405333982888 1525 3632071 YPR165W RHO1 SGTC_1560 lithocholic acid 53.1 µM 0.443780951875123 0.344021866150972 no 1166 0.328600480650346 1591 9903 A bile acid which acts as a detergent. SGTC_3284 9108171 64.8615 µM 0.441122376532542 0.344915027614758 no 1167 0.32956220239795 1582 8687505 SGTC_2281 7943571 200 µM 0.439877588487339 0.345333517873706 no 1168 0.330012884333064 1668 1244024 SGTC_1177 0983-0204 23.6 µM 0.43938174528807 0.345500270089482 no 1169 0.330192475699343 1683 766818 SGTC_81 0411-0046 9.971 µM 0.433035686254142 0.34763708963785 no 1170 0.332494422228116 1517 12925265 SGTC_3178 9107506 49.47 µM 0.430304293260091 0.348558290372697 no 1171 0.333487152240388 1603 8897194 SGTC_556 4058-0063 51.5 µM 0.429427413261282 0.348854220288633 no 1172 0.333806103808235 1603 6615692 SGTC_953 1188-0045 9.7 µM 0.429369202033737 0.348873868701054 no 1173 0.333827281498099 1639 6144426 SGTC_1522 st012842 45.6 µM 0.426372686482204 0.349885848299205 no 1174 0.334918150381568 1488 3491067 YOR116C RPO31 SGTC_340 k038-0059 454 µM 0.424631616053828 0.350474331207713 no 1175 0.335552620832079 1624 23733424 SGTC_265 mycophenolic acid 32.932 µM 0.424202090119356 0.35061956651922 no 1176 0.335709218321313 1658 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1 SGTC_191 3914-0123 66.505 µM 0.424079241339093 0.350661109310367 no 1177 0.335754012042807 1535 3144412 SGTC_1124 fisetin 1.16336 µM 0.423565143812093 0.350834976935454 no 1178 0.335941490102014 1566 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster. SGTC_2229 7354935 190 µM 0.423168361544776 0.350969189939349 no 1179 0.336086214241337 1613 318112 SGTC_489 paxilline 115 µM 0.421205598356757 0.351633374739819 no 1180 0.336802478346622 1555 105008 A toxic potassium channel blocker. SGTC_2706 st078239 82.5 µM 0.420927790548455 0.351727419538642 no 1181 0.336903905660359 1584 15434492 SGTC_590 k048-0076 22.4 µM 0.420316737927145 0.351934307853132 no 1182 0.337127042003338 1672 6832814 SGTC_1512 0259-0544 12.2 µM 0.418525073454302 0.352541176643386 no 1183 0.337781629164341 1662 18476 SGTC_273 hydroxyurea 18.1 mM 0.417650065119767 0.352837694193088 no 1184 0.338101493272682 1617 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12 SGTC_1240 0356-0016 42.1 µM 0.416163117860767 0.35334178690862 no 1185 0.338645323064627 1635 4305613 SGTC_2683 piperine 63.03 µM 0.415653704378187 0.353514543347159 no 1186 0.338831711262553 1597 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_331 k048-0133 24.5 µM 0.415590739378008 0.353535898645904 no 1187 0.338854752131971 1578 6813582 SGTC_1644 st010134 20.9 µM 0.415095208529868 0.353703979677267 no 1188 0.339036103457285 1654 3818134 SGTC_2265 7929201 200 µM 0.41450714672868 0.353903483650618 no 1189 0.3392513670937 1540 1265108 SGTC_439 amiodarone 34.4 µM 0.413614024352139 0.354206558228405 no 1190 0.339578400382489 1676 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1 SGTC_2486 5283202 22.39 µM 0.41299099390712 0.354418033780919 no 1191 0.339806606069288 1570 1377751 SGTC_2317 5986382 200 µM 0.412467794648871 0.354595658262721 no 1192 0.339998290621431 1733 877883 SGTC_1807 st050092 58.9 µM 0.410792770473268 0.355164536152595 no 1193 0.340612247381477 1579 5008496 SGTC_1022 4477-0945 21.3 µM 0.409479294068204 0.355610849851791 no 1194 0.341093979539128 1581 4648966 SGTC_3098 9119039 49.47 µM 0.408902779276861 0.355806809702548 no 1195 0.341305504667043 1616 17161528 SGTC_1854 st056233 32.9 µM 0.408338430920608 0.355998671040958 no 1196 0.341512614194203 1728 5393174 SGTC_1242 0402-0103 60.1 µM 0.406739822695646 0.356542347233976 no 1197 0.342099544438395 1570 432868 SGTC_1435 4092-0789 56.7 µM 0.406380463496587 0.356664603132033 no 1198 0.342231536044451 1709 2248285 SGTC_1231 0242-0792 125 µM 0.406123317171076 0.356752094710712 no 1199 0.342325996987513 1586 3707635 SGTC_2087 5276107 200 µM 0.405286974509737 0.357036704401351 no 1200 0.342633289935587 1597 144405 SGTC_1784 st039334 36.3 µM 0.402446311654037 0.358003983053265 no 1201 0.343677796385954 1730 3496984 SGTC_618 k072-0232 33.2 µM 0.401179353111585 0.358435691699019 no 1202 0.344144040381799 1638 5872756 YGL099W LSG1 SGTC_1722 st034304 3.6505 µM 0.400722882869998 0.3585912756208 no 1203 0.344312080721813 1579 4036148 YLR033W RSC58 SGTC_2823 7987624 58.44 µM 0.400037388844811 0.358824964396821 no 1204 0.344564489297517 1615 2239440 SGTC_356 1634-0012 32.5 µM 0.39918450790997 0.359115790095053 no 1205 0.344878628730062 1761 735457 SGTC_23 0213-0011 39.996 µM 0.399071723289386 0.359154254881735 no 1206 0.344920178410383 1724 627608 SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM 0.398979808302013 0.359185603211477 no 1207 0.344954041133123 1618 4000243 SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM 0.397106513175752 0.359824711550183 no 1208 0.345644458589312 1593 803109 SGTC_2100 5377183 190 µM 0.396028113131426 0.360192805100642 no 1209 0.346042144446586 1746 2844202 SGTC_334 1502-1024 68.5 µM 0.395843739311499 0.360255750961804 no 1210 0.346110153726381 1648 3296216 SGTC_2805 7950783 58.44 µM 0.395478972358757 0.360380294823871 no 1211 0.346244718567355 1662 1178958 YDL195W SEC31 SGTC_633 0437-0093 97.7 µM 0.395163867747974 0.360487894198979 no 1212 0.346360978284828 1610 2831118 SGTC_68 0986-0284 82.829 µM 0.394954595150598 0.360559361019776 no 1213 0.346438198653324 1551 423278 YIL048W NEO1 SGTC_2812 7970281 58.44 µM 0.394115073096137 0.360846107661785 no 1214 0.346748041530588 1744 2233435 SGTC_817 1391-0715 46 µM 0.393087053976994 0.361197343799041 no 1215 0.347127592758337 1606 1353946 SGTC_1588 farnesol 29.9 µM 0.392269669608123 0.36147669737587 no 1216 0.347429485786516 1608 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_3045 9092950 49.47 µM 0.392175156024032 0.361509003601839 no 1217 0.34746439971432 1755 44120432 SGTC_1340 1486-1359 257 µM 0.391885135582968 0.361608143301628 no 1218 0.347571543213858 1649 4309068 SGTC_1052 3253-3998 198 µM 0.391521888029479 0.36173232783876 no 1219 0.347705756498221 1611 5450317 SGTC_1751 st044839 27.194 µM 0.391227339926582 0.361833036580289 no 1220 0.347814600616026 1668 5291326 SGTC_2583 asiatic acid 100 µM 0.390878676731151 0.361952260143674 no 1221 0.347943458050616 1669 5320556 A kinase inhibitor; arrests cells at G2/M. SGTC_1658 st012944 20 µM 0.390457619396605 0.362096256364263 no 1222 0.348099094007522 1703 24207260 SGTC_444 curcumin 90.4 µM 0.386751289468902 0.363364613852213 no 1223 0.349470170810986 1679 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. SGTC_982 1491-0518 27.5 µM 0.384712559649514 0.364062935668383 no 1224 0.3502251944177 1661 3091256 SGTC_2422 chlorphenesin carbamate 384.24 µM 0.384550330340714 0.364118523159395 no 1225 0.350285299933382 1630 2724 A muscle relaxant with antifungal properties. SGTC_2971 9092186 9.93 µM 0.382766039306818 0.364730094691395 no 1226 0.350946622016557 1532 25236400 SGTC_1188 1403-0014 4.57 µM 0.382068023285182 0.364969435744705 no 1227 0.351205454769783 1644 9614867 SGTC_3099 9120367 49.47 µM 0.381990051559385 0.364996174553305 no 1228 0.35123437191401 1651 24824940 SGTC_815 1582-0027 36.9 µM 0.381321531344247 0.365225456820317 no 1229 0.351482339370803 1698 3128206 SGTC_802 4112-3352 742 µM 0.38074168656509 0.365424365112806 no 1230 0.351697466544083 1747 704594 SGTC_3302 9125395 16.351 µM 0.38034743865888 0.365559627463292 no 1231 0.351843762884606 1680 17599668 SGTC_1327 1436-0082 2.18 µM 0.380212841137244 0.365605810300464 no 1232 0.351893713957189 1674 15992205 SGTC_2321 7390090 138.78 µM 0.379612246109249 0.365811909019775 no 1233 0.352116634536325 1587 649046 SGTC_2003 4023581 200 µM 0.379004247700233 0.366020587720224 no 1234 0.352342354773926 1655 16641307 SGTC_2166 5933061 31.504 µM 0.378195759923356 0.366298140264759 no 1235 0.352642587528569 1774 2877375 SGTC_3215 9129942 49.47 µM 0.37763583791154 0.366490401595962 no 1236 0.352850568957032 1774 17682944 SGTC_3 0833-0587 95.581 µM 0.376896253616763 0.366744405214933 no 1237 0.353125352831359 1664 5382644 SGTC_1863 st057641 20.1 µM 0.376541906010886 0.366866123421379 no 1238 0.353257033682236 1733 3921635 SGTC_1116 jasmonic acid  1.58368 µM 0.376351785644513 0.366931435180632 no 1239 0.353327692487281 1727 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid. SGTC_934 2950-0684 338 µM 0.374768802894331 0.367475384214974 no 1240 0.353916208874881 1779 1121253 SGTC_1870 st057514 26.5 µM 0.373978640215714 0.367747001761531 no 1241 0.354210103842142 1646 5393161 SGTC_1632 st005650 90 µM 0.37347073771409 0.367921627622598 no 1242 0.354399060164402 1673 2759605 SGTC_702 1488-0190 94 µM 0.37342961033324 0.367935769138693 no 1243 0.354414362462979 1796 949357 SGTC_136 0097-0015 404.482 µM 0.373123342831876 0.368041083850989 no 1244 0.35452832305527 1725 4861337 SGTC_492 tmb-8 126 µM 0.372285393088855 0.368329276216107 no 1245 0.354840186462563 1744 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1 SGTC_2679 rapamycin 1 nM 0.368393007500879 0.369668936423783 no 1246 0.356290105316136 1699 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2 SGTC_843 0310-0051 143 µM 0.36574857994743 0.370579985675131 no 1247 0.357276346196985 1695 2065037 SGTC_593 1203-0218 61.7 µM 0.365692115613225 0.370599446513839 no 1248 0.357297415032653 1774 3666956 SGTC_2458 5808907 16.39 µM 0.364993490795592 0.370840259957873 no 1249 0.357558132579099 1778 2731747 SGTC_661 1304-0007 33.6 µM 0.362742659532571 0.3716164570365 no 1250 0.358398564686201 1652 3117130 SGTC_1209 2323-2347 50.3 µM 0.360864325780905 0.372264598629905 no 1251 0.359100436521041 1769 5412760 SGTC_2512 diallyl trisulfide 49.23 µM 0.360524616327342 0.37238185816193 no 1252 0.35922742570483 1684 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent SGTC_1667 st014849 34.6 µM 0.359879112892375 0.372604703014687 no 1253 0.359468768737065 1713 5348460 SGTC_654 1124-0271 80.9 µM 0.359468238008857 0.372746570107212 no 1254 0.359622417253455 1632 5403748 SGTC_736 0958-0254 92.6 µM 0.358925609214993 0.372933955709251 no 1255 0.359825370513496 1729 6812352 SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM 0.3582446265043 0.373169161508106 no 1256 0.360080126640865 1673 442882 SGTC_3327 9140648 26.9345 µM 0.358101747787044 0.373218516638618 no 1257 0.360133585565189 1807 8029710 SGTC_956 1185-0240 191 µM 0.356159404298594 0.373889673684145 no 1258 0.360860595913898 1706 1416193 SGTC_2771 fluoxetine 41.05 µM 0.355406862837268 0.374149809665102 no 1259 0.361142404120279 1760 3386 A selective serotonin reuptake inhibitor. SGTC_580 1123-0028 41 µM 0.352630595494818 0.375109995274358 no 1260 0.362182698674762 1724 1677248 YPR107C YTH1 SGTC_2864 9034755 47.6 µM 0.35201784797577 0.375322021531219 no 1261 0.362412438677814 1760 4930451 SGTC_2077 5212015 200 µM 0.349445572681989 0.376212504652689 no 1262 0.363377412499552 1636 780900 SGTC_1556 plumbagin 1.48 µM 0.349370088268787 0.376238646205906 no 1263 0.363405743163163 1699 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_1620 st003704 16.5 µM 0.348156903587766 0.376658870787532 no 1264 0.363861175689024 1802 2834414 SGTC_2916 7875993 68.79 µM 0.346671532544519 0.377173574691372 no 1265 0.36441904958686 1866 1299250 SGTC_453 enantio-paf c16 10 µM 0.346088937018521 0.377375512650887 no 1266 0.364637938638068 1704 13871343 A lipid and platelet activating factor SGTC_1273 0849-0096 14.1 µM 0.345412372509056 0.377610064008178 no 1267 0.364892188500309 1681 5286025 SGTC_305 1682-2595 20.8 µM 0.342975678915304 0.378455190332666 no 1268 0.365808378530633 1750 226033 SGTC_549 1661-1316 519 µM 0.342139580726464 0.378745311223974 no 1269 0.366122925884381 1831 2857282 SGTC_1790 st045711 43.5 µM 0.342058159513005 0.378773567534847 no 1270 0.366153562059212 1826 585119 SGTC_162 k030-0015 37.8 µM 0.341607472892562 0.378929984943426 no 1271 0.366323156316981 1858 1809920 YMR134W ERG29 SGTC_2334 9017922 200 µM 0.340260266675273 0.379397670778042 no 1272 0.366830268225769 1843 3163164 SGTC_2480 5767542 37.17 µM 0.339837708537207 0.379544399240447 no 1273 0.366989374416488 1762 2867358 SGTC_1697 st025554 27.742 µM 0.339148394211979 0.37978379295191 no 1274 0.36724897157919 1689 1269519 SGTC_948 3448-0295 75.3 µM 0.338249430452452 0.380096065567527 no 1275 0.367587614317391 1693 678569 SGTC_2894 9048625 32.47 µM 0.337888240225265 0.380221554073932 no 1276 0.367723704933384 1832 4092861 SGTC_756 0508-1999 28.3 µM 0.335734419336649 0.380970118525404 no 1277 0.368535573985135 1635 6753853 SGTC_1433 4060-0023 7.6 µM 0.333923248748178 0.381599939348672 no 1278 0.369218737898159 1775 3840627 SGTC_1412 3909-8563 178 µM 0.332228956310293 0.382189400640833 no 1279 0.369858190184468 1831 23767530 SGTC_2628 lathosterol 100 µM 0.330808742550691 0.382683717739278 no 1280 0.370394478378723 1729 6710616 SGTC_170 4197-0004 226 µM 0.328225656931663 0.383583271540074 no 1281 0.371370525012888 1798 218692 SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM 0.327276407334539 0.383914003607779 no 1282 0.371729417490529 1738 4620898 SGTC_400 oxethazaine 37.5 µM 0.324118272414516 0.385014950220742 no 1283 0.372924246820258 1732 4621 A local anesthetic. SGTC_614 0462-0418 107 µM 0.321857490799678 0.385803643834491 no 1284 0.373780329166131 1730 5188303 SGTC_2682 pyrogallin 40.03 µM 0.321312317219586 0.385993903251281 no 1285 0.373986861559762 1796 822798 An ATP competetive kinase inhibitor. SGTC_1390 3413-2614 145 µM 0.320902135495843 0.386137070117837 no 1286 0.374142277782396 1746 3421432 SGTC_2614 arthonioic acid 13.39 µM 0.320551682317412 0.386259402048812 no 1287 0.374275079304637 1694 6710684 SGTC_3279 9140807 49.47 µM 0.319133573363834 0.386754533603067 no 1288 0.374812612909388 1738 45595718 SGTC_1613 st002381 52.1 µM 0.318501709281211 0.386975207848378 no 1289 0.375052199145549 1770 551167 SGTC_1264 0783-0040 158 µM 0.318047654739572 0.387133805884922 no 1290 0.37522439446299 1669 2855798 SGTC_2517 totarol 10 µM 0.317967965679473 0.387161642653929 no 1291 0.375254618250969 1690 460178 An antibacterial membrane disruptor. YGL001C ERG26 SGTC_2867 9039098 71.43 µM 0.316230628265181 0.387768668707994 no 1292 0.375913730841284 1723 6463460 SGTC_873 0591-4978 488 µM 0.315851614797567 0.387901132604386 no 1293 0.376057569494155 1920 3305145 SGTC_208 k072-0098 12.366 µM 0.315414737820215 0.38805383578178 no 1294 0.37622338917662 1770 5948901 SGTC_1615 st002656 86.5 µM 0.314324597609025 0.388434951844241 no 1295 0.376637259033662 1733 1584458 SGTC_1091 telmisartan 47.6 µM 0.314303550287554 0.388442311104925 no 1296 0.376645251010188 1837 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension. SGTC_2071 5230951 39.92 µM 0.312112896475896 0.389208498479542 no 1297 0.377477362898771 1844 1799272 SGTC_2670 beta-carotene 100 µM 0.310939989497997 0.389618903361984 no 1298 0.377923121519095 1823 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.) SGTC_988 1497-1057 103 µM 0.310569007074554 0.389748737259653 no 1299 0.378064145784103 1930 3533044 SGTC_1101 ebselen 5.29 µM 0.310030101040257 0.38993736183186 no 1300 0.378269033022571 1900 3194 A potent scavenger of hydrogen peroxide and hydroperoxides. SGTC_3073 9114972 49.47 µM 0.308648137926198 0.390421186420128 no 1301 0.378794599330563 1894 41905075 SGTC_2052 5265182 7.135 µM 0.308543332893392 0.390457885543105 no 1302 0.378834466278022 1865 1239884 SGTC_1045 1348-1485 165 µM 0.306630614476936 0.391127824973475 no 1303 0.379562274236031 1778 6810614 SGTC_1625 st003711 30.1 µM 0.306194533248867 0.391280609969469 no 1304 0.379728267242176 1845 24207034 YER133W GLC7 SGTC_449 xestospongin c 11.1929 µM 0.302972393301411 0.392410034279955 no 1305 0.380955450182289 1842 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1 SGTC_778 3456-2434 196 µM 0.302774365048325 0.392479476806245 no 1306 0.381030910357488 1927 5539063 SGTC_3274 9138298 49.47 µM 0.301872855502207 0.392795652208025 no 1307 0.381374494584888 1784 17015756 SGTC_3126 9127922 49.47 µM 0.300779705095258 0.393179134355631 no 1308 0.381791242594615 1814 45595682 SGTC_1155 4088-0394 48.2 µM 0.299125090701404 0.393759777745587 no 1309 0.382422301309345 1748 2326248 SGTC_351 caspofungin 25 nM 0.298400128964587 0.394014258516285 no 1310 0.382698895322613 1829 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1 SGTC_998 3996-0085 177 µM 0.296116984009235 0.394815998106421 no 1311 0.383570371981547 1888 715391 SGTC_2828 7998861 71.43 µM 0.292540205526693 0.396072899382698 no 1312 0.384936812024616 1923 2988188 SGTC_1302 1159-0335 255 µM 0.29105557563587 0.396594925461493 no 1313 0.385504407609512 1741 649284 SGTC_2168 5727979 200 µM 0.290936015628449 0.396636973271824 no 1314 0.385550127826695 1783 695210 SGTC_2994 9053520 71.4286 µM 0.290311770225507 0.396856532350264 no 1315 0.385788867540135 1899 4647384 SGTC_2977 9011197 71.43 µM 0.289330579800657 0.397201701907096 no 1316 0.38616420661874 1867 2704722 SGTC_2293 7624732 200 µM 0.288953675684206 0.397334313114525 no 1317 0.386308413753006 1742 894453 SGTC_1873 rapamycin 2 nM 0.288528232581564 0.397484016700285 no 1318 0.386471211238949 1762 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1 SGTC_456 gingerol 170 µM 0.288329118666672 0.397554085469627 no 1319 0.386547409833051 1830 442793 A herb. SGTC_966 1300-0360 30.2 µM 0.287547174755882 0.397829285780152 no 1320 0.386846693028739 1773 70588 SGTC_1966 st070145 16.1 µM 0.286310619386382 0.398264587509351 no 1321 0.387320112665985 1749 3748532 SGTC_1394 3474-0001 65.7 µM 0.285457548167912 0.398564966051803 no 1322 0.387646811784364 1778 5017666 YIL048W NEO1 SGTC_177 1327-0068 8.361 µM 0.285074700058627 0.398699791881184 no 1323 0.387793456301809 1810 15389900 YOR207C | YLR033W RET1 | RSC58 SGTC_1080 nisoldipine 24.4 µM 0.28462847182536 0.398856953249756 no 1324 0.387964397871616 1802 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class. SGTC_1233 0325-0408 14.2 µM 0.280748783728868 0.400224066060802 no 1325 0.389451544430175 1878 12874 SGTC_3289 9119912 71.43 µM 0.279993507113705 0.400490350963405 no 1326 0.389741243158504 1833 17014829 SGTC_1463 k081-0032 34.1 µM 0.276177721292788 0.401836372314212 no 1327 0.391205783931853 1794 977755 SGTC_1472 k841-0093 193 µM 0.27605713380674 0.401878928719247 no 1328 0.39125209201668 1907 X1472 SGTC_1756 st041558 35.5 µM 0.275784919049683 0.401975000024532 no 1329 0.391356633771609 1981 3955792 SGTC_40 0327-0103 19.753 µM 0.27534564297991 0.402130043878592 no 1330 0.391525350546912 1760 409036 SGTC_2681 menadione 3.18 µM 0.274744703786832 0.402342172175526 no 1331 0.391756191805574 1843 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_976 1348-1067 47.6 µM 0.274221135544838 0.402527012392076 no 1332 0.391957343314257 1814 5310671 YGL099W LSG1 SGTC_755 1995-0008 37.3 µM 0.273675952212311 0.402719506748263 no 1333 0.39216682989447 1917 689533 SGTC_3345 9148410 3.559 µM 0.272371748428752 0.40318009308591 no 1334 0.392668096645109 1916 4903596 SGTC_98 0074-0023 107.663 µM 0.272349545270814 0.403187935411325 no 1335 0.392676631905241 1775 3563821 SGTC_3242 9133940 49.47 µM 0.271506255029153 0.403485820779272 no 1336 0.393000844754682 1893 17248444 SGTC_473 2-arachidonoylglycerol 10 µM 0.270679172873707 0.403778035174292 no 1337 0.393318898329299 1774 5282280 An endocannabinoid. SGTC_3028 9087778 49.47 µM 0.270385885300572 0.403881668806246 no 1338 0.393431698871386 1767 17217395 SGTC_980 1473-0395 201 µM 0.269792038143981 0.404091526301964 no 1339 0.393660124208263 1794 768876 SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM 0.269164902291293 0.404313177537941 no 1340 0.393901393889406 1774 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1 SGTC_1614 st002383 48.6 µM 0.268935442662825 0.404394284089457 no 1341 0.393989681039398 1873 1947235 SGTC_3001 9076041 71.4286 µM 0.268686458675894 0.404482296517929 no 1342 0.394085486567285 1826 16004211 SGTC_1835 st008666 49.2 µM 0.267665303215919 0.404843311502917 no 1343 0.394478479781051 1776 690455 SGTC_2326 6164455 177.58 µM 0.265447611123523 0.405627623605081 no 1344 0.395332331408285 1816 2888790 SGTC_764 1951-2361 146 µM 0.264843183711701 0.405841452115201 no 1345 0.395565134266864 1761 5438930 SGTC_3177 9107506 49.47 µM 0.263655403860251 0.406261735233779 no 1346 0.396022731200927 1947 8897194 SGTC_3163 9099914 49.47 µM 0.262430118827647 0.406695402357464 no 1347 0.396494927334739 1924 16268368 SGTC_1182 1222-0449 220 µM 0.26078091756913 0.407279287447032 no 1348 0.397130730483935 1868 658318 SGTC_1249 0481-0015 10.2 µM 0.260538395397237 0.407365167685013 no 1349 0.397224251190554 1793 4227577 SGTC_655 k060-0012 42 µM 0.260491416017683 0.407381804205933 no 1350 0.39724236792799 1826 5994525 SGTC_3265 9137266 49.47 µM 0.258471308993636 0.408097330034644 no 1351 0.398021594451108 2022 17224265 SGTC_1708 st033234 31.827 µM 0.258436874206902 0.40810952956718 no 1352 0.398034880698953 1941 674664 SGTC_2253 7938677 135.83 µM 0.25841889529622 0.408115899158674 no 1353 0.398041817692147 1978 2301972 SGTC_100 0086-0128 49.5915 µM 0.258303410305353 0.408156813907917 no 1354 0.398086377255476 1752 93297 SGTC_2118 5526350 200 µM 0.258138158570425 0.408215362073976 no 1355 0.398150141490682 1888 743594 SGTC_3221 9128209 49.47 µM 0.257277933387461 0.408520170199579 no 1356 0.398482112922063 1839 16460723 SGTC_3183 9108214 49.47 µM 0.256284628336919 0.408872202062104 no 1357 0.398865532898682 1957 4974831 SGTC_2891 9063876 19.48 µM 0.254950877592812 0.409345005036414 no 1358 0.399380519838222 2022 6472478 SGTC_55 0767-0285 6.563 µM 0.254045802539967 0.40966592139178 no 1359 0.399730086613861 1976 3116166 SGTC_1419 3993-2473 62.6 µM 0.254019822006398 0.409675134316078 no 1360 0.399740122253094 1878 704026 SGTC_1868 st057644 42.7 µM 0.252547773745839 0.410197216815944 no 1361 0.400308846179552 1867 688665 SGTC_3175 9106517 49.47 µM 0.251344554175846 0.410624073759762 no 1362 0.400773865611361 1848 41468073 SGTC_197 4544-0043 41.561 µM 0.248400299864633 0.411669029761633 no 1363 0.401912350795884 1878 896523 SGTC_522 1273-0010 11.6 µM 0.248256709259261 0.411720008114866 no 1364 0.401967895833219 1890 5705015 SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM 0.247543641363305 0.411973187591991 no 1365 0.402243760619274 1906 676296 Flavone; oxidizing agent. SGTC_3328 9140624 29.0385 µM 0.247210925372509 0.412091333152194 no 1366 0.402372495222768 1981 4904392 SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM 0.246164038378515 0.412463128713885 no 1367 0.402777626169028 1840 6857784 SGTC_139 0099-0334 718.624 µM 0.244985476726596 0.412881781723637 no 1368 0.40323383832997 2018 97690 SGTC_3075 9116269 49.47 µM 0.244398190665611 0.413090436668344 no 1369 0.403461221469661 1887 17015205 YNL244C SUI1 SGTC_2722 naftopidil 47.16 µM 0.24307806529331 0.413559549236367 no 1370 0.403972461522729 1952 4418 An a1-adrenergic receptor antagonist or alpha blocker.  SGTC_2193 5925765 200 µM 0.242233045120988 0.413859895829478 no 1371 0.404299795530211 1959 877370 SGTC_3022 9087993 49.47 µM 0.240641702498878 0.414425645441983 no 1372 0.404916412921387 1926 17173644 SGTC_1673 st016611 27.3 µM 0.239471211699633 0.41484188842669 no 1373 0.405370108430414 1955 5226799 SGTC_405 ebelactone b 50 µM 0.239355704375353 0.41488296964661 no 1374 0.405414887283827 1872 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).  SGTC_1990 st072050 59.8 µM 0.239144544184911 0.41495807307556 no 1375 0.405496751190676 1824 17233948 SGTC_1208 2323-2347 50.3 µM 0.236941501547022 0.415741814999621 no 1376 0.406351086488164 2029 5412760 SGTC_531 3788-1495 174 µM 0.236058209071062 0.416056144445335 no 1377 0.406693750949294 1839 2896655 SGTC_3307 9126885 69.2785 µM 0.235581773957047 0.4162257114851 no 1378 0.406878608857355 1818 24824909 SGTC_1019 4262-0212 3.4 µM 0.235406493282475 0.416288099194347 no 1379 0.406946623381036 2020 4677213 SGTC_3225 9130819 49.47 µM 0.233271732652331 0.417048094074926 no 1380 0.407775203619254 1966 4547121 SGTC_2948 9070189 9.45 µM 0.232312532172576 0.417389679610429 no 1381 0.408147639706768 2024 6473636 YDL196W YDL196W SGTC_2708 st078559 56 µM 0.232111561033512 0.417461256327013 no 1382 0.408225682831799 1977 17250902 SGTC_2979 9012552 45.46 µM 0.228995038167898 0.418571567692483 no 1383 0.409436386319944 2053 17100905 SGTC_2439 5492030 7.2 µM 0.228035918767853 0.418913400418573 no 1384 0.40980915845701 2018 5722370 SGTC_2869 9037858 32.47 µM 0.226411816279255 0.419492374390503 no 1385 0.410440569235687 2010 27187042 SGTC_1048 3161-0300 24.5 µM 0.226262003869562 0.419545789603463 no 1386 0.410498824308575 1920 2165101 SGTC_769 0302-0231 76 µM 0.225917227448772 0.419668724342137 no 1387 0.410632899310096 1929 571869 YER009W NTF2 SGTC_767 0929-0023 86 µM 0.224550133088012 0.42015625756126 no 1388 0.411164631068934 1954 1204563 SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM 0.222508088195049 0.420884719657647 no 1389 0.411959188805268 1959 688761 SGTC_2016 5121758 140 µM 0.219620420112906 0.421915304304934 no 1390 0.41308339335484 1982 2795203 SGTC_1132 3456-3614 2.5 µM 0.217991770723048 0.422496792094626 no 1391 0.413717761631 2057 3125502 SGTC_1976 st070609 63.5 µM 0.217679794918243 0.422608198261739 no 1392 0.413839303752886 1980 682556 SGTC_2407 paclitaxel 400 µM 0.21738328096517 0.422714088759348 no 1393 0.413954829769297 1961 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_2837 9008476 45.46 µM 0.217138551903077 0.422801490142742 no 1394 0.414050185272016 1951 2992805 SGTC_2963 9082507 9 µM 0.216806009976764 0.422920258687981 no 1395 0.41417976403743 1950 16459611 SGTC_554 4483-2211 187 µM 0.216764812877809 0.422934972868037 no 1396 0.414195817608952 1928 747107 SGTC_1822 st052468 42 µM 0.215359391946021 0.423437004917721 no 1397 0.41474356384389 1923 2873678 SGTC_2191 5911152 200 µM 0.213337157594461 0.424159587549144 no 1398 0.415531996508956 1939 2875902 SGTC_2054 5233173 129 µM 0.213229030591091 0.42419823057896 no 1399 0.415574162884719 1946 6889 SGTC_2943 9068529 45.32 µM 0.211714594717522 0.424739544512915 no 1400 0.416164850629927 2014 3270634 SGTC_2426 5582046 32.21 µM 0.209621016498922 0.425488098353158 no 1401 0.416981737632437 1977 2251934 SGTC_2070 5230947 200 µM 0.208231113817302 0.425985203258171 no 1402 0.417524257848805 2049 2835538 SGTC_995 3931-2021 34.6 µM 0.207441522865011 0.426267656440241 no 1403 0.417832528613761 1938 730143 SGTC_2314 7727897 200 µM 0.205935359902334 0.426806547178325 no 1404 0.418420702089918 1881 900724 SGTC_431 k089-0097 107 µM 0.204002377749049 0.427498349839997 no 1405 0.419175820404912 2011 5499420 SGTC_99 0109-0120 622.8 µM 0.202064663046747 0.428192070065881 no 1406 0.41993308640643 2033 759414 SGTC_1581 himbacine 57.9 µM 0.201476663314044 0.428402623541141 no 1407 0.420162937630103 1908 5281825 An alkaloid muscarinic receptor antagonist. SGTC_2939 9044578 71.43 µM 0.201186817192602 0.428506420391663 no 1408 0.420276249552952 1924 2653634 SGTC_495 decylubiquinone 155 µM 0.20107281266285 0.428547247931433 no 1409 0.420320820090485 1913 2971 A Co-enzyme Q analog. A free radical scavenger. SGTC_2665 lovastatin 100 µM 0.200784636047095 0.428650453750224 no 1410 0.42043348847216 1948 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1 SGTC_2421 5690543 90.72 µM 0.199635180580421 0.429062161210355 no 1411 0.420882955731018 1946 3397993 SGTC_891 0929-0073 133 µM 0.19932389987951 0.429173667814116 no 1412 0.421004692429079 2021 5603632 SGTC_2815 7968870 71.43 µM 0.19699891217634 0.430006700328375 no 1413 0.421914194530097 1932 2977326 YHR190W ERG9 SGTC_1370 2001-0092 44.6 µM 0.195315554530649 0.430610034454367 no 1414 0.422572960406029 2055 790957 SGTC_2497 7-hydroxyflavone 100 µM 0.1939534407602 0.431098349849729 no 1415 0.423106169217444 2056 5281894 SGTC_211 3455-0679 143.504 µM 0.193355879582516 0.431312607771526 no 1416 0.42334013317051 1962 748649 SGTC_2350 9023895 38.85 µM 0.19303387535369 0.431428072045058 no 1417 0.423466219144907 1994 2997209 SGTC_1953 st076800 12.1 µM 0.192668820170689 0.431558980616093 no 1418 0.423609171896718 1855 297591 SGTC_501 nsc-95397 161 µM 0.191729446509024 0.431895873977058 no 1419 0.423977069450796 2051 262093 SGTC_1265 0819-1001 68.8 µM 0.188066226350876 0.433210108197326 no 1420 0.425412368061879 2038 3106768 SGTC_1316 1272-0050 65.9 µM 0.188052194347993 0.433215143815148 no 1421 0.425417867901734 1987 7340392 SGTC_2714 st079313 56.9 µM 0.187734018793584 0.433329329318319 no 1422 0.425542580620365 1962 2939799 SGTC_1642 st009582 77.7 µM 0.187575873148434 0.433386086032768 no 1423 0.425604570472078 2097 6739311 SGTC_2699 st077704 54.6 µM 0.187552952389367 0.433394312152476 no 1424 0.425613555092483 1980 645852 SGTC_603 3794-0023 45.9 µM 0.183428313512834 0.434875086128084 no 1425 0.427230980880612 2080 3802260 SGTC_2913 7966556 36.57 µM 0.183389325745415 0.434889087399925 no 1426 0.4272462753305 2066 2976516 SGTC_2686 alizarin 95.37 µM 0.183224968898028 0.434948112064304 no 1427 0.427310751821275 1933 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1 SGTC_2687 chenodiol 100 µM 0.180655557984724 0.435871039602364 no 1428 0.428318972151275 1990 5702181 A cholesterol synthesis inhibitor. SGTC_2843 9000894 45.46 µM 0.180598758608492 0.435891445795893 no 1429 0.428341265173512 2043 2242070 SGTC_2274 7947094 46.08 µM 0.180538364096191 0.435913143793683 no 1430 0.428364969491114 2136 2971028 SGTC_477 mead ethanolamide 10 µM 0.179575898999802 0.436258955595146 no 1431 0.428742763442994 2077 16061185 SGTC_1924 st058459 75.1 µM 0.179404131873757 0.436320676314849 no 1432 0.428810193628503 2039 688683 SGTC_977 1348-1378 135 µM 0.178514593520094 0.43664033703292 no 1433 0.429159430648658 2067 X977 SGTC_332 4112-0506 40.9 µM 0.178126192256245 0.436779924249057 no 1434 0.429311936256766 1982 2790355 SGTC_255 tunicamycin 200.472 nM 0.173822578771567 0.438327119418411 no 1435 0.431002449609601 2107 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_277 nystatin 15.5 µM 0.173583369019386 0.438413145773022 no 1436 0.431096451594138 2007 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_47 0149-0135 24.25 µM 0.17270840908776 0.43872782999927 no 1437 0.431440316814487 1927 5239155 SGTC_3136 9095672 49.47 µM 0.172532162697295 0.438791222691654 no 1438 0.43150958914434 2145 17217380 SGTC_781 4335-2806 94.4 µM 0.172208305416741 0.438907712488493 no 1439 0.431636884324195 2101 845254 SGTC_3128 9127691 49.47 µM 0.171809805792484 0.439051058012918 no 1440 0.431793528127354 2022 41316314 SGTC_1159 4092-0538 61.2 µM 0.169875439463354 0.439746988108392 no 1441 0.432554048414899 2009 717301 SGTC_359 0081-0058 15.9 µM 0.16926129222488 0.439967979902428 no 1442 0.432795560481643 2073 3494159 SGTC_2799 7812892 81.82 µM 0.169056560103169 0.440041653886681 no 1443 0.432876076527761 2082 20205235 SGTC_2289 7946404 165.07 µM 0.168610222905203 0.44020227798492 no 1444 0.433051619490924 1990 1246120 YPR165W RHO1 SGTC_129 0088-0017 176.636 µM 0.167219642739916 0.440702771322959 no 1445 0.433598614676188 2118 182446 SGTC_1956 st077085 54 µM 0.166946083753435 0.440801241009217 no 1446 0.433706236170976 1965 24208685 SGTC_1135 dihydrocapsaicin 536.708 nM 0.166741339125458 0.440874942826957 no 1447 0.433786788460953 1928 107982 A Capsaicinoid. SGTC_1098 clofazimine 15.1 µM 0.165560766839592 0.441299952693024 no 1448 0.434251312315397 2087 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2 SGTC_658 3253-0951 102 µM 0.165207843500302 0.441427019392315 no 1449 0.434390195938939 2030 1184878 SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM 0.165050791822003 0.441483566297944 no 1450 0.434452002067818 2084 2333 A French combination drug. SGTC_2106 5357045 167.29 µM 0.162963828458043 0.442235096215286 no 1451 0.435273457302508 2081 668842 SGTC_454 lyso-paf C-16 6.67 µM 0.162826440066143 0.442284578048591 no 1452 0.435327544956134 1949 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_3103 9120822 49.47 µM 0.162342592256728 0.442458847946264 no 1453 0.43551803787237 2108 17141819 SGTC_2918 7977171 22.06 µM 0.162341116600807 0.442459379457724 no 1454 0.435518618867219 2046 2236483 SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM 0.159542282832811 0.443467667139259 no 1455 0.436620824014527 2100 66535 A nucleotide analog. SGTC_171 k064-0041 9.68 µM 0.159373317029326 0.443528549325807 no 1456 0.436687380062468 1977 53325 SGTC_1308 1187-1617 41.4 µM 0.158788186454725 0.443739395349676 no 1457 0.436917878281733 2023 2882570 SGTC_1628 st004252 77.7 µM 0.158683369020759 0.443777166960661 no 1458 0.43695917087134 2102 692968 SGTC_2487 5918373 44.05 µM 0.155364767338781 0.444973307903655 no 1459 0.438266879221536 2177 2876279 SGTC_2192 5915882 198.485 µM 0.155249179987649 0.445014978751997 no 1460 0.438312439118143 2105 2876149 SGTC_2525 harmine 47.85 µM 0.15334374794515 0.44570200074422 no 1461 0.439063601369517 2071 5280953 A monoamine oxidase inhibitor SGTC_1094 duloxetine 25.4 µM 0.152385020134625 0.446047741147574 no 1462 0.43944163564889 2024 60834 A selective serotonin reuptake inhibitor. SGTC_2238 6671620 73.2395 µM 0.150155772074457 0.44685182000085 no 1463 0.440320859484196 2170 729941 SGTC_1406 3909-7906 11.9 µM 0.149411229583799 0.447120421677048 no 1464 0.440614575632468 2109 X1406 SGTC_748 act1.228 77.9 µM 0.14919720763125 0.447197636882163 no 1465 0.440699011660409 2026 4421505 YNR035C ARC35 SGTC_831 k061-1017 217 µM 0.147873666152095 0.447675190784158 no 1466 0.44122123553219 2106 1240153 SGTC_2075 5212009 200 µM 0.147376307122554 0.447854665134857 no 1467 0.441417502742195 2137 780898 SGTC_226 1,3-diallylurea 8.28947 mM 0.145378081965863 0.448575841343701 no 1468 0.442206184433479 2103 74537 YKL182W FAS1 SGTC_1774 st048371 48.465 µM 0.144873713308331 0.448757899177919 no 1469 0.442405290594984 2044 4242727 SGTC_347 4534-1311 26.2 µM 0.144683783560291 0.448826459366441 no 1470 0.442480271634787 2130 2862016 SGTC_591 4299-0174 154 µM 0.144677879116489 0.4488285907568 no 1471 0.442482602641988 2078 5509088 SGTC_503 tyrphostin 8 294 µM 0.144221781160166 0.448993237782675 no 1472 0.442662670934997 2159 92970 A tyrosine kinase inhibitor. YOR207C RET1 SGTC_1337 1486-1011 40.3 µM 0.143330813980014 0.449314893777743 no 1473 0.4430144605156 2175 X1337 SGTC_2702 st077768 96.8 µM 0.142793171817124 0.449509008890958 no 1474 0.443226764959831 2030 6484119 SGTC_596 1155-0152 116 µM 0.142234596166416 0.449710694814976 no 1475 0.443447352894749 2066 280313 SGTC_321 4534-3890 65.3 µM 0.142042984786379 0.449779883278988 no 1476 0.443523026468368 2144 699746 SGTC_2870 9038528 12.99 µM 0.141801930444939 0.449866927143852 no 1477 0.443618229602581 2068 6463316 SGTC_3067 9117431 49.47 µM 0.14128197815276 0.450054688273369 no 1478 0.44382359307696 2031 17150885 SGTC_733 4069-0007 56.1 µM 0.139929302332981 0.450543208324782 no 1479 0.444357924568717 2120 5717425 YNL287W SEC21 SGTC_2853 9015042 58.44 µM 0.139603263494675 0.450660968771401 no 1480 0.44448673098982 2099 6457456 SGTC_2425 5628681 7.85 µM 0.135263300717835 0.452228909374946 no 1481 0.446201850073252 2101 5714958 SGTC_838 0109-0203 71.4 µM 0.135141034423035 0.452273092618665 no 1482 0.446250183484385 2156 759422 SGTC_2132 5317594 122.667 µM 0.135120263013035 0.452280598820232 no 1483 0.446258394764581 2080 794577 SGTC_1603 st002045 67.8 µM 0.134650153420676 0.45245048772029 no 1484 0.446444242979327 2194 5887985 SGTC_1047 2043-3044 82 µM 0.134488867756352 0.452508775379613 no 1485 0.446508006681339 2077 669592 SGTC_1821 st053465 65.6 µM 0.134120858374445 0.452641775564565 no 1486 0.446653503030597 2066 675086 SGTC_1921 5740136 50 µM 0.134114520966253 0.452644065977925 no 1487 0.446656008654012 2180 1774243 SGTC_2898 9056270 58.44 µM 0.133584999045753 0.452835446945201 no 1488 0.446865373444359 2098 19154699 SGTC_2026 5148700 152 µM 0.132765202482733 0.453131761203443 no 1489 0.447189537538557 2080 79838 SGTC_1759 st043059 70 µM 0.13273685829976 0.453142006634275 no 1490 0.447200746032423 2039 669426 SGTC_1354 1498-1681 81 µM 0.132529378549701 0.453217004256892 no 1491 0.447282793621852 2064 5754243 SGTC_1201 1889-3372 45.9 µM 0.130654688031697 0.453894723224567 no 1492 0.448024239344126 2055 5392199 SGTC_1346 1488-2224 62.4 µM 0.129891484009427 0.454170667517862 no 1493 0.448326140991944 2189 3722427 SGTC_669 0108-0021 26.2 µM 0.129609445472124 0.454272647067958 no 1494 0.448437714940932 2254 17201 SGTC_3000 9075062 71.4286 µM 0.128660212258382 0.454615893108475 no 1495 0.448813259842869 2056 17057871 SGTC_2984 9022109 38.96 µM 0.128456765954246 0.454689464420671 no 1496 0.448893755234089 2208 6459207 SGTC_285 1486-1325 46 µM 0.128387013042367 0.454714689189937 no 1497 0.448921354096171 2164 22310230 SGTC_1974 st069448 26.9 µM 0.127955486609725 0.454870746296291 no 1498 0.449092099962754 2191 6323587 YNR016C ACC1 SGTC_3310 9130229 44.1445 µM 0.127816275613711 0.454921092011636 no 1499 0.449147184817278 2156 7761258 SGTC_2949 9072542 2.23 µM 0.126697001596235 0.455325904178142 no 1500 0.449590109546809 2083 16457352 SGTC_913 3487-1245 167 µM 0.125023419062922 0.455931281665595 no 1501 0.450252505035759 2079 4016153 SGTC_1549 4'-methoxyflavonol 74.6 µM 0.124762770643506 0.456025574091321 no 1502 0.450355680881074 2171 97141 SGTC_2992 9074591 71.4286 µM 0.123722434354481 0.456401951777536 no 1503 0.450767524044243 2212 17741321 SGTC_3203 9113543 49.47 µM 0.123088365709322 0.456631367281282 no 1504 0.451018562020024 2098 17018012 SGTC_2427 5545055 42.75 µM 0.122989562529424 0.456667117050868 no 1505 0.451057681555176 2101 5372858 SGTC_3123 9126162 49.47 µM 0.122460469026119 0.456858563923376 no 1506 0.451267175725347 2152 25239884 SGTC_118 0083-0097 135.343 µM 0.117816789855312 0.458539254693006 no 1507 0.453106412911491 2153 5207356 SGTC_8 0354-0001 70 µM 0.117663080852761 0.458594899566739 no 1508 0.453167310363853 2123 4993152 SGTC_438 sphingosine 6.67 µM 0.117249966138072 0.458744457063827 no 1509 0.453330986346221 2005 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes. SGTC_1869 3',7'-dimethoxyflavone 40.3 µM 0.116010027277076 0.459193379841339 no 1510 0.453822297419315 2129 688664 SGTC_2263 7948595 193.29 µM 0.115625238407491 0.45933270416284 no 1511 0.453974779851687 2148 2971371 SGTC_894 0960-0238 55.9 µM 0.115263426145752 0.459463713672691 no 1512 0.454118163404598 2188 6741907 YDL195W SEC31 SGTC_20 0481-0013 4.944 µM 0.113547675694441 0.46008503375092 no 1513 0.454798183857511 2127 182045 SGTC_354 2783-3500 4.88 µM 0.112343852612796 0.460521029234893 no 1514 0.455275386251656 2054 6740761 SGTC_2352 9027995 87.8 µM 0.111971884347743 0.460655756730627 no 1515 0.455422849695837 2127 2997347 SGTC_1149 3909-7961 23.3 µM 0.111244682505907 0.460919163423734 no 1516 0.455711159991666 2050 735261 SGTC_2017 5132927 60.65 µM 0.110395642425559 0.461226723993688 no 1517 0.4560478044242 2134 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis SGTC_3210 9128157 49.47 µM 0.11029397053083 0.461263555693242 no 1518 0.456088119455656 1960 17590849 SGTC_3246 9135460 32.98 µM 0.109706551738277 0.461476360745846 no 1519 0.456321052124035 2177 41446951 SGTC_2025 5147754 141 µM 0.108703457539636 0.461839778594737 no 1520 0.456718849694628 2203 315777 YLR208W SEC13 SGTC_480 am 92016 50 µM 0.108669629771218 0.461852034845109 no 1521 0.45673226554807 2067 2129 K+ channel blocker. SGTC_796 1234-0020 70.7 µM 0.103150638486282 0.463852115496351 no 1522 0.458921707815516 2237 46495034 SGTC_651 3253-0966 34.4 µM 0.102864657605922 0.463955780215287 no 1523 0.459035194002887 2147 781462 SGTC_1326 1431-2094 10.8 µM 0.102808212725834 0.463976241112466 no 1524 0.459057593497322 2192 616278 SGTC_261 5-fluorouridine 15.376 µM 0.101307361404131 0.464520324608309 no 1525 0.459653236352912 2207 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_348 k064-0012 10.7 µM 0.098924096113465 0.465384433727433 no 1526 0.460599268404994 2214 5066323 SGTC_627 1391-0720 175 µM 0.098458619331017 0.465553222511529 no 1527 0.460784064621343 2155 997839 SGTC_2766 oltipraz 83.91 µM 0.0979476794385676 0.46573850402705 no 1528 0.460986919630396 2217 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40 SGTC_1710 st031758 61.5 µM 0.0978091875657369 0.465788726448514 no 1529 0.461041905872816 2221 5394341 SGTC_363 0455-0021 3.06 µM 0.0973593586583822 0.465951855277117 no 1530 0.461220509221492 2197 4597466 SGTC_705 1124-0212 310 µM 0.0973113022928744 0.465969283083219 no 1531 0.461239590334285 2240 9554485 SGTC_1278 0874-0585 172 µM 0.0964998406641763 0.466263572259577 no 1532 0.461561800234163 2159 766306 SGTC_293 4049-0273 38.5 µM 0.0956923960008383 0.466556422931681 no 1533 0.461882440148815 2187 1380311 SGTC_1589 2',5'-dimethoxyflavone 47.2 µM 0.0949027300303775 0.466842842995878 no 1534 0.462196044029218 2127 688667 SGTC_1105 epirubicin 18.1 µM 0.0948372617351897 0.466866589800588 no 1535 0.46222204482881 2114 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_1546 5-methoxyflavanone 78.7 µM 0.0943314564956578 0.467050060564035 no 1536 0.462422931324163 2242 147795 SGTC_3154 9100113 49.47 µM 0.0942518585519883 0.467078933769249 no 1537 0.462454545457162 2150 25237525 SGTC_1202 1988-0068 29.6 µM 0.0941803019218976 0.467104890231688 no 1538 0.462482966002106 2102 2850480 SGTC_974 1326-0144 138 µM 0.0934600857482654 0.467366149322616 no 1539 0.462769028908508 2120 5411856 SGTC_15 0266-0086 27.098 µM 0.0932762249313929 0.467432847263097 no 1540 0.462842059739951 2238 1712902 YIL048W NEO1 SGTC_235 0330-0087 5 mM 0.0931236822315069 0.467488184836961 no 1541 0.462902651742078 2207 46494818 YHR062C RPP1 SGTC_2661 dactinomycin 12.96 µM 0.0925938945664155 0.467680379596442 no 1542 0.463113097170536 2246 45006140 An Actinomycin D Classic transcription inhibitor. SGTC_564 3555-0129 330 µM 0.0922288426692981 0.467812816401692 no 1543 0.463258111281999 2248 563260 SGTC_2355 9061122 103.12 µM 0.0920663620808506 0.4678717637152 no 1544 0.463322657041012 2226 5302957 SGTC_3021 9087658 49.47 µM 0.0915673790471407 0.468052797180523 no 1545 0.463520885139903 2248 25237042 SGTC_2055 5235184 200 µM 0.0913691492625135 0.468124717743874 no 1546 0.463599637254528 2184 2836034 SGTC_1654 st012436 41.8 µM 0.0890010556802068 0.468983975308051 no 1547 0.464540535569797 2244 4323132 SGTC_2741 miltefosine 3.04 µM 0.0887333054273212 0.469081137066465 no 1548 0.464646931511018 2202 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis. SGTC_881 0833-0569 170 µM 0.0882347457419412 0.469262060325111 no 1549 0.464845050946296 2045 5418700 SGTC_2759 disulfiram 3.38 µM 0.0878855860109088 0.469388771335663 no 1550 0.464983806484232 2213 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_1298 1079-1278 263 µM 0.0874612760079683 0.469542758754944 no 1551 0.465152432353777 2200 2840950 SGTC_1753 st043925 64 µM 0.0865367878195431 0.469878282852801 no 1552 0.465519856646136 2238 670181 SGTC_3230 9131665 49.47 µM 0.0864795478230159 0.469899057645539 no 1553 0.465542606814117 2204 15943720 SGTC_1565 sinapyl alcohol 95.1 µM 0.0852113484916033 0.470359361229259 no 1554 0.466046684302912 2152 5280507 A phenol propionate derived from cinnamic acid. SGTC_677 0929-0063 136 µM 0.0851979177212723 0.470364236253036 no 1555 0.466052022990859 2257 1539583 SGTC_508 roscovitine 141 µM 0.084045623609815 0.470782505804167 no 1556 0.466510078833381 2261 160355 A CDKinase inhibitor. SGTC_1782 st039423 80.636 µM 0.0836303876834936 0.470933239609609 no 1557 0.466675152841918 2080 2068169 SGTC_3290 9121031 71.43 µM 0.0836116510030663 0.470940041265737 no 1558 0.466682601607702 2187 17014854 SGTC_3026 9090633 49.47 µM 0.0830271570432929 0.47115222434221 no 1559 0.466914972980804 2215 25236842 SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM 0.0826636501140962 0.471284188810983 no 1560 0.467059494459805 2170 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_1853 st056710 91.2 µM 0.0817891012701724 0.471601690487171 no 1561 0.467407211481577 2283 269167 SGTC_1271 0832-2808 169 µM 0.0813805431640099 0.471750022172342 no 1562 0.467569661043466 2251 3663794 SGTC_3243 9134147 49.47 µM 0.0806761474180625 0.472005770280866 no 1563 0.467849753286194 2281 24282180 SGTC_2659 sanguinarine 24.21 µM 0.0801118214992183 0.472210670945144 no 1564 0.468074160385982 2250 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis. SGTC_3304 9125678 46.087 µM 0.0792730437361264 0.472515235692311 no 1565 0.468407723396319 2226 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2 SGTC_2417 cerulenin 830 nM 0.0791768477099399 0.472550166020821 no 1566 0.468445979809818 2288 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1 SGTC_2022 5136654 200 µM 0.0746844358359355 0.474181663813682 no 1567 0.470232895744348 2205 1713771 SGTC_858 0438-0351 2.77 µM 0.0742230882059204 0.474349235244887 no 1568 0.470416437393682 2171 2799119 SGTC_1938 st074717 56.4 µM 0.0736482700653803 0.474558027964628 no 1569 0.470645130721045 2282 17250979 SGTC_1260 0700-1617 7.75 µM 0.0729038546525877 0.474828434328482 no 1570 0.470941313269715 2203 2853078 SGTC_2694 st077685 81.9 µM 0.0715416115736667 0.475323294424377 no 1571 0.471483354067415 2248 2838096 SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM 0.071099774984898 0.475483807983412 no 1572 0.471659173627634 2255 6728940 SGTC_898 1000-0849 28.3 µM 0.0701846429059552 0.475816276341882 no 1573 0.472023348683472 2273 6751807 SGTC_3256 9138902 49.47 µM 0.0690701591160363 0.476221192084238 no 1574 0.47246688692993 2295 17228773 SGTC_1356 1502-0781 85.8 µM 0.0679283091040099 0.476636076023234 no 1575 0.472921351693992 2248 567702 SGTC_504 lovastatin 124 µM 0.0667464927541049 0.47706550814458 no 1576 0.473391760473178 2153 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1 SGTC_3049 9092223 49.47 µM 0.0644869703193229 0.477886615955086 no 1577 0.474291240847884 2224 8623917 SGTC_3303 9125618 40.5795 µM 0.0643200906272894 0.477947263605488 no 1578 0.474357678284635 2238 22695467 SGTC_2785 7756463 72.73 µM 0.0624561821782352 0.478624682197049 no 1579 0.475099777667543 2268 2201551 SGTC_137 0438-0332 85.389 µM 0.0618674073953904 0.478838679338296 no 1580 0.475334211444388 2284 2063393 YER012W | YPR107C PRE1 | YTH1 SGTC_2928 9011484 9.79 µM 0.0612152890548009 0.479075706560668 no 1581 0.475593876831576 2229 2994751 SGTC_1199 1638-0010 4.46 µM 0.0611262922690627 0.479108055039557 no 1582 0.475629315047631 2256 3111136 SGTC_3200 9114385 49.47 µM 0.0609768822531914 0.47916236277926 no 1583 0.475688810038909 2215 17018030 YLR208W SEC13 SGTC_2833 9001315 45.46 µM 0.0607872709580865 0.479231283487149 no 1584 0.475764313939098 2164 2989378 SGTC_2803 7707263 71.43 µM 0.0598305026223296 0.479579063080026 no 1585 0.476145315753235 2255 2199229 SGTC_2120 5538279 151.968 µM 0.0596229987857326 0.479654491549669 no 1586 0.476227950284875 2266 2058197 SGTC_3082 9117008 49.47 µM 0.0591103200422681 0.479840855429469 no 1587 0.476432119405629 2188 41448529 SGTC_1928 4'-methoxychalcone 40.3 µM 0.0573939385224325 0.480464809216795 no 1588 0.47711569570165 2321 641818 SGTC_2502 avocadyne acetate 18.59 µM 0.0571648674552123 0.480548086757154 no 1589 0.477206932042526 2303 3952079 SGTC_300 r073-0011 5.04 µM 0.0561760609301175 0.480907571686009 no 1590 0.47760077582564 2315 2735780 SGTC_903 1134-0042 114 µM 0.0553158757096495 0.481220308417076 no 1591 0.477943407271725 2282 701009 SGTC_2109 5483026 200 µM 0.0549977429572663 0.481335974580483 no 1592 0.478070130966137 2246 759335 SGTC_2237 6667747 47.222 µM 0.0546999403766927 0.481444250558711 no 1593 0.478188758432867 2161 729940 YDL015C TSC13 SGTC_1139 k015-0024 46.9 µM 0.0533836842225601 0.481922835306488 no 1594 0.478713102389632 2307 2766652 SGTC_3286 9117135 37.221 µM 0.0528791525638073 0.482106287666089 no 1595 0.478914097498337 2261 3438150 SGTC_3306 9127676 59.7925 µM 0.0528761161015023 0.482107391763269 no 1596 0.47891530717919 2226 41905287 SGTC_2539 epi(13)torulosol 80 µM 0.0527587718555857 0.482150059762046 no 1597 0.478962055508229 2264 6708597 SGTC_1849 st056239 19.2 µM 0.0517604757648414 0.482513062315138 no 1598 0.479359774540798 2243 5393181 SGTC_2753 fluvastatin 17.09 µM 0.051522182478294 0.482599713182623 no 1599 0.479454713130884 2260 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5 SGTC_597 k018-0003 82.8 µM 0.0506799725306535 0.482905973532887 no 1600 0.479790267871502 2295 6786234 SGTC_1192 1488-0095 21.4 µM 0.0490687284519548 0.483491912609799 no 1601 0.480432262227742 2233 915875 SGTC_2838 9002687 71.43 µM 0.048976499801122 0.483525453231528 no 1602 0.480469011950695 2284 6457060 SGTC_2765 myclobutanil 7.74 µM 0.0488763197893189 0.483561885641981 no 1603 0.480508930186426 2255 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11 SGTC_260 nsc-65238 3.989 µM 0.0474886629866017 0.484066548020585 no 1604 0.481061882884381 2313 3246252 SGTC_2850 9015429 58.44 µM 0.0471041529767566 0.484206390992423 no 1605 0.481215108708456 2278 6457570 SGTC_2224 6650123 117.647 µM 0.0453269721287024 0.4848527612979 no 1606 0.481923344438912 2317 2908370 SGTC_541 4513-1321 94 µM 0.0450357099965129 0.484958698755165 no 1607 0.482039422678862 2229 747515 SGTC_2492 derrusnin 100 µM 0.0450336731660743 0.484959439592044 no 1608 0.482040234433056 2307 1715307 Part of coumarin class of compounds. SGTC_904 1141-0088 396 µM 0.0444265571813656 0.48518026239236 no 1609 0.482282196486829 2231 1378119 SGTC_717 1532-0246 73.2 µM 0.0426509751311311 0.485826110458312 no 1610 0.482989880077086 2290 9561992 SGTC_2737 bleomycin 30.5 nM 0.0425047169225662 0.485879311922633 no 1611 0.483048175794965 2324 16211318 Bleomycin acts by induction of DNA strand breaks. SGTC_2623 humulene 100 µM 0.0420512820208405 0.486044250588326 no 1612 0.48322890855142 2283 6187145 An anti-inflammatory. SGTC_1317 1273-0028 910 nM 0.0414524685490816 0.486262074914151 no 1613 0.483467592429978 2316 5917803 YLR359W | YHR072W ADE13 | ERG7 SGTC_2358 9037157 4 µM 0.0413924421456295 0.486283910339498 no 1614 0.483491518964633 2285 2388925 SGTC_540 1187-0821 17.3 µM 0.0400874726604479 0.486758620893088 no 1615 0.484011694571653 2320 847520 SGTC_388 3',4'-dichloroisocoumarin 16.7 µM 0.0392564725157548 0.487060924785402 no 1616 0.484342954872707 2290 1609 A potent and irreversible inhibitor of serine proteases. SGTC_1916 st067606 49.2 µM 0.0388838116884945 0.487196494958985 no 1617 0.484491511604667 2307 19590279 SGTC_1791 st048313 56.1 µM 0.0377597240080548 0.487605435386978 no 1618 0.484939628520047 2348 1204976 SGTC_3161 9100388 49.47 µM 0.0374315824073307 0.487724814998465 no 1619 0.485070445594678 2314 25236368 SGTC_1723 st034307 2.5525 µM 0.0358123304744889 0.488313923126133 no 1620 0.485716000538934 2330 867466 SGTC_1426 4048-4480 71.7 µM 0.0357661760065597 0.488330715193323 no 1621 0.485734401719078 2341 14224343 SGTC_3145 9085516 49.47 µM 0.0355424935482359 0.488412096358336 no 1622 0.485823581406865 2233 25236195 SGTC_2953 9074162 66.49 µM 0.0350755794106379 0.48858197272521 no 1623 0.486009737117031 2347 16451992 SGTC_2127 5253358 187.912 µM 0.034917713657957 0.48863940915274 no 1624 0.4860726778847 2341 20612 SGTC_307 1501-1223 22.3 µM 0.0346105883641844 0.488751151476702 no 1625 0.48619512913293 2312 2830329 SGTC_3115 9123671 49.47 µM 0.0344959578183498 0.488792858081435 no 1626 0.486240832812652 2359 3286988 SGTC_2064 5220758 200 µM 0.0344292069899931 0.48881714442561 no 1627 0.486267446731366 2293 788518 SGTC_216 k038-0035 28.382 µM 0.033157218861688 0.489279947123741 no 1628 0.486774606875369 2335 4444231 YPR107C YTH1 SGTC_3356 9151811 4.48 µM 0.0326158954720781 0.489476907720386 no 1629 0.486990446910391 2342 1859254 YPR165W RHO1 SGTC_3034 9090421 49.47 µM 0.0309586591721016 0.490079909145987 no 1630 0.487651254528888 2344 17173761 SGTC_3015 9080845 49.47 µM 0.0303176854367557 0.490313139783424 no 1631 0.487906846058436 2333 5296973 SGTC_2437 5741531 144.16 µM 0.0296107034533915 0.490570392631267 no 1632 0.488188764468164 2343 2262990 SGTC_2040 5100729 123 µM 0.0286417288485082 0.490922984312989 no 1633 0.488575165457786 2335 11840 YJR013W | YDR381W GPI14 | YRA1 SGTC_2484 5809818 12.04 µM 0.0285952970894736 0.490939880139368 no 1634 0.48859368146558 2333 2870548 SGTC_1246 0422-0085 105 µM 0.0282082802277407 0.491080710447533 no 1635 0.488748016593326 2345 264295 SGTC_2861 9024595 19.48 µM 0.0269874633552321 0.491524956734902 no 1636 0.489234866592036 2359 16482810 SGTC_3305 9127027 53.8275 µM 0.0256672107011632 0.492005398787391 no 1637 0.489761388652937 2318 41905295 SGTC_154 3389-1638 511.116 µM 0.0250303708858087 0.492237150004288 no 1638 0.49001536936465 2253 5238686 SGTC_151 3013-0144 2.285 µM 0.0245383898941416 0.49241618770873 no 1639 0.490211581109093 2352 906558 YHR107C CDC12 SGTC_364 0083-0097 67.7 µM 0.0245101294533143 0.492426472064295 no 1640 0.490222852003912 2337 5207356 SGTC_2981 9013952 38.96 µM 0.0243441174837344 0.49248688616045 no 1641 0.490289061441539 2306 2996344 SGTC_1444 4112-3581 28 µM 0.0242317495452891 0.492527778535293 no 1642 0.490333876542876 2352 2877249 SGTC_954 1189-0853 2.85 µM 0.0232185619240683 0.492896496171442 no 1643 0.490737966162084 2371 2828194 SGTC_1314 1222-0010 41.1 µM 0.022573228338843 0.493131348132653 no 1644 0.490995349537871 2339 3526027 SGTC_2099 5377090 177.372 µM 0.0215889341099999 0.493489560344953 no 1645 0.491387930388464 2341 2243829 SGTC_2481 5478948 45.16 µM 0.0199825414482881 0.494074182729429 no 1646 0.492028649845894 2356 77792 SGTC_2511 berberine 10.47 µM 0.0197217328412317 0.494169101322964 no 1647 0.492132676925109 2373 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_1344 1488-0097 29.1 µM 0.0180655238829353 0.494771868914823 no 1648 0.492793290708355 2349 747966 SGTC_2889 9059656 51.95 µM 0.0180030884429286 0.494794592171218 no 1649 0.492818194794981 2360 3949838 SGTC_935 2996-0153 430 µM 0.0179360330396792 0.494818996873016 no 1650 0.492844941711755 2374 23738523 SGTC_1044 1222-0021 1.78 µM 0.0179170024501038 0.494825923027782 no 1651 0.492852532598755 2316 4306703 SGTC_1592 4',5'-dihydroxyflavone 8.85 µM 0.0174710193461555 0.494988238357115 no 1652 0.493030426264313 2367 688669 SGTC_3352 9151559 45.5865 µM 0.0166058583956633 0.495303115597664 no 1653 0.493375525439825 2361 17159339 SGTC_2876 9059903 25.97 µM 0.0163064708654977 0.495412079042613 no 1654 0.49349494761221 2383 6916095 SGTC_1645 Cervolide 78 µM 0.0153622693037517 0.495755727672964 no 1655 0.493871582303168 2357 23173 A fragrance. SGTC_1297 1068-0111 14.1 µM 0.0150736718687005 0.495860765327851 no 1656 0.493986702690683 2374 767057 SGTC_1771 st048882 4.1505 µM 0.0149060734778967 0.495921764414958 no 1657 0.494053557263415 2369 4580403 SGTC_2365 9042475 200 µM 0.0145095311097987 0.496066090297447 no 1658 0.494211737669309 2361 6464479 SGTC_1170 0310-0127 64.8 µM 0.0142378705276131 0.496164964402012 no 1659 0.494320103366196 2375 774975 SGTC_1757 st041620 31.8375 µM 0.0140936625002591 0.496217450727297 no 1660 0.49437762827341 2358 5289815 SGTC_3089 9117425 49.47 µM 0.0138738089227014 0.496297469327686 no 1661 0.494465328585727 2331 9401657 SGTC_2200 6600604 21.907 µM 0.0126305229917614 0.49674998229926 no 1662 0.494961284326505 2380 2904777 SGTC_1119 parthenolide 318.541 nM 0.0122931276544472 0.496872783249621 no 1663 0.495095875139945 2369 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs. SGTC_2011 4012611 177 µM 0.0120924004317486 0.49694584158407 no 1664 0.495175947763614 2377 2049887 SGTC_3147 9097027 49.47 µM 0.0119055960871162 0.49701383252513 no 1665 0.495250466550092 2368 25236841 SGTC_1963 st076565 50.3 µM 0.0117327250563845 0.497076752252871 no 1666 0.495319427296402 2379 4914280 SGTC_2032 5185112 25.99 µM 0.0115166418010051 0.497155400000763 no 1667 0.495405626218524 2384 5718189 SGTC_3204 9114183 49.47 µM 0.011328737867431 0.497223791420601 no 1668 0.495480584151836 2386 17027248 SGTC_297 0986-0032 24 µM 0.00829658731425405 0.498327413542204 no 1669 0.496690178508368 2389 2847425 SGTC_846 0335-0850 148 µM 0.00814294106581153 0.498383337100294 no 1670 0.496751472422355 2387 6819598 SGTC_2793 7325131 81.82 µM 0.0079053409705429 0.498469817911991 no 1671 0.496846258094438 2389 4176441 SGTC_1752 st044819 83.042 µM 0.00757402528173744 0.498590409101038 no 1672 0.496978429971473 2389 441209 YML126C ERG13 SGTC_213 1246-0773 967 nM 0.00620221762425378 0.499089716364788 no 1673 0.497525689020872 2367 6251622 SGTC_317 4495-0002 170 µM 0.00605839993160109 0.499142062880011 no 1674 0.497583062901007 2385 15991618 SGTC_2380 9035439 200 µM 0.00520371188917626 0.499453151030697 no 1675 0.497924028681456 2374 6462575 SGTC_2247 cerulenin 830 nM 0.00394412095857589 0.499911615716384 no 1676 0.498426527470121 2397 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12 SGTC_1448 4255-0083 152 µM 0.0038754486771207 0.499936610995648 no 1677 0.498453923537285 2393 5399660 SGTC_2262 9014885 67.46 µM 0.00378922999768517 0.499967992798436 no 1678 0.498488319561277 2381 6457424 SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM 0.0036133561861975 0.499967992798436 no 1679 0.498558482580001 2400 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W SGTC_1677 st019204 53.9 µM 0.00354383421064001 0.499942688247928 no 1680 0.498586217657869 2375 3945625 SGTC_689 0833-0039 98 µM 0.00304649362268631 0.499761666649568 no 1681 0.498784626766942 2400 5374726 SGTC_410 α-linolenic acid 100 µM 0.00233325182446825 0.499502061609924 no 1682 0.499069168040981 2386 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_1216 1165-0504 9.65 µM 0.00227984297315796 0.499482621916517 no 1683 0.499090475033235 2400 6304004 SGTC_2555 cholic acid 100 µM 0.0018751403653987 0.499335318761422 no 1684 0.499251927664944 2383 6708657 Influences liver metabolism. SGTC_628 1636-0253 16 µM 0.000806809825620809 0.498946469619734 no 1685 0.499678129483236 2400 4456143 SGTC_1601 4'-hydroxyflavanone 55.5 µM 0.000350442835504544 0.498780362218687 no 1686 0.499860193538915 2404 165506 SGTC_1510 1123-0200 71.5 µM 0.000153414011578335 0.498708648186934 no 1687 0.499938796664615 2403 5378812 YNL149C | YNL150W PGA2 | YNL150W SGTC_798 1287-0182 476 µM 1.96668301559951e-06 0.498653524815906 no 1688 0.499999215406993 2404 1649755 SGTC_1888 azatryptophan 97.5 µM -0.000196673640307492 0.498581224311034 no 1689 0.499921538569947 2406 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides SGTC_1749 st037932 54.2 µM -0.000811217830833687 0.498357544678439 no 1690 0.49967637094416 2407 594497 SGTC_2547 epiafzelechin trimethyl ether 100 µM -0.00106610850325098 0.498264770615625 no 1691 0.499574684323126 2407 6708630 An antioxidant. SGTC_120 rhodamine 6G 52.259 µM -0.00126883464863027 0.498190983250431 no 1692 0.499493808347646 2407 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase SGTC_119 0121-0043 24.815 µM -0.00162199903897823 0.498062440187927 no 1693 0.499352916288314 2410 1092378 SGTC_1855 st056195 39.6 µM -0.0022420767549926 0.497836747802049 no 1694 0.499105541535922 2406 4028379 SGTC_2415 st077333 57.7 µM -0.00288509799950892 0.49760270529241 no 1695 0.498849014021656 2414 2766255 SGTC_1541 2',3',6-trimethoxyflavone 64 µM -0.00328376631834913 0.497457601111936 no 1696 0.498689969131023 2414 688801 SGTC_2398 5228213 48.84 µM -0.00451722278221115 0.49700865947847 no 1697 0.498197894970935 2411 80771 YMR134W ERG29 SGTC_135 0933-0004 26.348 µM -0.00555708580271994 0.496630183046535 no 1698 0.497783054927804 2421 21230617 YGL099W LSG1 SGTC_421 streptovitacin 30 mM -0.00583938989537154 0.496527434017003 no 1699 0.497670433718104 2480 91467 include heat shock SGTC_929 2805-0021 398 µM -0.00599340503276318 0.496471377873938 no 1700 0.497608991643399 2439 3098024 SGTC_2945 9067681 61.76 µM -0.00709411008259121 0.496070761686156 no 1701 0.497169883284516 2416 16456930 SGTC_517 1365-0151 113 µM -0.00710431826479927 0.496067046300899 no 1702 0.497165810911649 2439 768657 SGTC_728 3030-5151 22.5 µM -0.0078160597651729 0.495808000659653 no 1703 0.49688187504168 2421 3125388 SGTC_2408 sulbentine 18.36 µM -0.00806328006811709 0.49571802269512 no 1704 0.496783251519095 2469 67686 An antifungal agent of unknown mechanism. YDL205C HEM3 SGTC_1685 st024049 53.0905 µM -0.0106765313913028 0.494766921519336 no 1705 0.495740761137379 2451 1941139 SGTC_2479 5617353 43.85 µM -0.0120325106611242 0.494273419908089 no 1706 0.495199838587121 2446 2731746 SGTC_180 1486-1293 102.781 µM -0.0122530987725173 0.494193138819745 no 1707 0.495111843150713 2430 4140536 SGTC_1029 k015-0030 64.7 µM -0.0124558401474458 0.494119353100319 no 1708 0.495030967216806 2490 2208316 SGTC_174 3553-0389 74.3 µM -0.0155349286067135 0.492998775488332 no 1709 0.493802709426261 2444 738071 SGTC_2863 9028737 58.44 µM -0.0156590239410639 0.492953614372718 no 1710 0.493753208571915 2431 6460917 SGTC_2587 piperic acid 92.2 µM -0.0158500036433687 0.492884112690494 no 1711 0.49367702814884 2441 5370536 SGTC_1108 betulinic acid 729.144 nM -0.0169683417132469 0.492477129461339 no 1712 0.493230935893881 2441 64945 Apoptosis-inducing agent of unknown mechanism. SGTC_1724 st037281 8.293 µM -0.0169687038168852 0.492476997686593 no 1713 0.493230791456225 2440 574124 YDL195W SEC31 SGTC_1322 1348-1070 12 µM -0.0175249533502804 0.492274571421874 no 1714 0.493008913003431 2428 6758089 SGTC_2734 clemastine 41.6 µM -0.0177184426650686 0.492204158668319 no 1715 0.492931733918995 2440 26987 Clemastine is a selective histamine H1 antagonist. SGTC_2098 5376439 882.5 nM -0.0180570448887795 0.492080938419143 no 1716 0.492796672785941 2472 2844116 SGTC_1469 k284-2957 126 µM -0.0180815080149506 0.492072036107143 no 1717 0.492786915003682 2458 23884841 SGTC_2416 tofa 880 nM -0.0187886841750792 0.491814691212715 no 1718 0.492504840475569 2458 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_2933 9026794 32.47 µM -0.0189816323591712 0.491744477003449 no 1719 0.492427879012473 2454 17586027 SGTC_1065 prochlorperazine maleate 2.48 µM -0.0190940017101487 0.491703585701741 no 1720 0.492383058250491 2436 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine. SGTC_727 3032-0951 202 µM -0.0193990327646878 0.491592585084228 no 1721 0.492261391003062 2460 3652836 SGTC_1702 st027038 51 µM -0.0195278258755815 0.491545717543526 no 1722 0.492210019717025 2460 5521182 SGTC_2604 4'-hydroxychalcone 11.32 µM -0.0197819388413457 0.49145324671558 no 1723 0.492108662890948 2477 5282362 SGTC_1516 st013856 110 µM -0.020434840596554 0.491215660146753 no 1724 0.491848245435346 2535 5281404 A mutagen and neurotoxin. SGTC_2082 5219693 150 µM -0.0204562951032396 0.491207853048121 no 1725 0.491839688114282 2434 2834649 SGTC_1069 diphenylcyclopropenone 8.49 µM -0.0212636361474927 0.490914071505507 no 1726 0.491517675713335 2455 65057 A dermal irritant. YDR527W RBA50 SGTC_1958 st076513 41.9 µM -0.0213125556296489 0.490896270460378 no 1727 0.491498164085239 2452 732122 YGL099W LSG1 SGTC_1742 st038235 28.8875 µM -0.0225676330449731 0.490439573444142 no 1728 0.490997581168671 2484 564103 YBR002C RER2 SGTC_278 4092-0821 23.9 µM -0.023096152664408 0.490247259673816 no 1729 0.490786787299 2466 877900 SGTC_3043 9092303 49.47 µM -0.0245193574888996 0.489729405933748 no 1730 0.490219171656412 2451 25236084 SGTC_2726 cimetidine 79.27 µM -0.0252559634678038 0.489461387896964 no 1731 0.489925399388791 2449 2756 A P450 inhibitor, histamine H2-receptor antagonist. SGTC_1960 st011366 51.8 µM -0.0259626318139098 0.489204267299421 no 1732 0.489643571944634 2460 3972846 SGTC_335 4077-0256 27.6 µM -0.0262501291671805 0.489099662942045 no 1733 0.489528916173389 2512 3121989 SGTC_1248 0469-0687 58.6 µM -0.0269030662974046 0.488862098094281 no 1734 0.489268523926109 2474 4017482 SGTC_124 0136-0217 7.121 µM -0.0269075644444177 0.488860461500687 no 1735 0.48926673007448 2472 3976905 SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM -0.0302195195751843 0.487655501483122 no 1736 0.487945990635084 2490 6708760 SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM -0.0313202286649876 0.48725506441088 no 1737 0.487507079089541 2446 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis. SGTC_2125 5246583 200 µM -0.0315944673898302 0.487155298569401 no 1738 0.487397727786105 2457 835267 SGTC_2092 5303694 80.6725 µM -0.0333722616771639 0.486508571084819 no 1739 0.486688864656194 2474 1963699 SGTC_1778 st046819 58.9 µM -0.0339774384606742 0.486288427380506 no 1740 0.486447570905625 2467 671715 SGTC_2059 5238311 157 µM -0.0340294917882175 0.486269492260832 no 1741 0.486426816634318 2473 703021 SGTC_1659 st012954 42.1 µM -0.0343291040859118 0.486160504736262 no 1742 0.48630735841887 2517 24207262 SGTC_546 peri-Naphthalide 147 µM -0.0344840754052476 0.486104132487092 no 1743 0.486245570390973 2506 223824 A penicillin ester. SGTC_879 0831-1030 162 µM -0.0361880819949398 0.485484302907238 no 1744 0.485566194478281 2474 1549252 SGTC_2389 9091542 195.52 µM -0.0366837559071651 0.485304008858966 no 1745 0.485368580416831 2512 3626624 YOL127W RPL25 SGTC_676 falcarinol 140 µM -0.0372526753391781 0.485097076542218 no 1746 0.485141769442772 2465 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer. SGTC_1037 k284-1091 78.7 µM -0.038203508136057 0.484751240366165 no 1747 0.48476271192572 2461 3334711 SGTC_1929 genistein trimethyl ether 50.5 µM -0.0383447022964203 0.484699886306178 no 1748 0.484706424848225 2476 136420 SGTC_1418 3966-3099 2.4 µM -0.0393646705035115 0.484328918862401 no 1749 0.484299823459575 2464 740335 SGTC_1833 st055984 71 µM -0.0401875388919975 0.484029647460552 no 1750 0.483971806064587 2499 676288 SGTC_3299 9121982 43.1275 µM -0.0405790071979904 0.483887276359435 no 1751 0.483815760099337 2509 17594604 YPL160W CDC60 SGTC_521 r062-0005 13.8 µM -0.0407343045174711 0.48383079764164 no 1752 0.483753856615878 2465 2832033 SGTC_234 nsc-17383 10.7 µM -0.041568893991806 0.483527278712711 no 1753 0.483421185398444 2487 408974 SGTC_2773 thioridazine 9.09 µM -0.0419406270116464 0.483392091946275 no 1754 0.483273014601906 2472 5452 An antipsychotic. SGTC_578 3460-0051 92 µM -0.0424503131058266 0.483206739404376 no 1755 0.48306986020583 2485 2876744 SGTC_1806 st050005 60.3 µM -0.0425701274230624 0.483163168232361 no 1756 0.483022104378644 2493 5194765 SGTC_1554 st069299 38.7 µM -0.0426088382881136 0.483149090844511 no 1757 0.48300667497763 2520 24207999 SGTC_2506 ethyl hematommate 54.16 µM -0.0427966833955828 0.483080780387731 no 1758 0.482931803917988 2527 3940691 An allergen. SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM -0.0428602240847181 0.483057673731081 no 1759 0.482906478088511 2503 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_2888 9058547 12.99 µM -0.0442388379061795 0.482556353112378 no 1760 0.482357012085458 2500 16476514 SGTC_2244 6635614 200 µM -0.045251162005483 0.482188248000201 no 1761 0.48195355730165 2495 836499 SGTC_2187 6125751 200 µM -0.0464202186173555 0.481763170132427 no 1762 0.481487660877978 2517 874498 SGTC_1951 sophoraflavanone G 9.2 µM -0.0476156242814699 0.481328532991413 no 1763 0.481011289888867 2485 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity. SGTC_2955 9076254 12.21 µM -0.0494266652800717 0.480670099657138 no 1764 0.480289639153377 2487 16459619 SGTC_2309 7664088 163.95 µM -0.0510920362537152 0.480064673521954 no 1765 0.479626090927666 2504 704922 SGTC_2222 6885208 172.143 µM -0.0511054028832692 0.480059814424308 no 1766 0.479620765371255 2503 609514 SGTC_2956 9076196 2.52 µM -0.0518054073502595 0.479805349791714 no 1767 0.479341873448395 2499 16423868 SGTC_1122 capsaicin 818.572 nM -0.0518696335394255 0.479782002789003 no 1768 0.479316285308448 2597 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_1376 2910-0861 41.3 µM -0.0522229345139699 0.479653574820207 no 1769 0.479175529382817 2509 1112859 SGTC_2748 diazoxide 86.69 µM -0.0526831406622031 0.479486289063071 no 1770 0.47899218608591 2548 3019 A potassium channel activatior. SGTC_228 caffeine 993.056 µM -0.0534624056017226 0.479203033119945 no 1771 0.478681741886844 2503 2519 Caffeine is a phosphodiesterase inhibitor. SGTC_3152 9099253 49.47 µM -0.053729546467544 0.479105932177931 no 1772 0.478575321059217 2547 25236131 SGTC_3084 9116877 49.47 µM -0.0559511945268609 0.478298451299117 no 1773 0.477690343668783 2495 27241325 SGTC_1727 st034309 9.9045 µM -0.0560040875995279 0.478279227839302 no 1774 0.47766927542027 2659 870305 SGTC_2576 guaiol 23.12 µM -0.0560225348297587 0.478272523389312 no 1775 0.477661927576118 2588 227829 SGTC_362 0310-0100 9.03 µM -0.0564305685857173 0.478124229427934 no 1776 0.477499402768319 2556 790235 SGTC_2104 5389443 200 µM -0.0583932979754916 0.47741094653312 no 1777 0.476717676552883 2595 2244536 SGTC_744 1594-0068 283 µM -0.0589202514619812 0.477219456604409 no 1778 0.476507813869042 2516 668392 SGTC_2690 usnic acid 100 µM -0.0592330236210663 0.477105800635365 no 1779 0.476383253382026 2567 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_1284 0929-0043 16 µM -0.05993457912991 0.476850874338136 no 1780 0.476103869611888 2569 1239883 SGTC_2991 9074669 71.4286 µM -0.0604879864436821 0.476649787766749 no 1781 0.475883491879792 2559 17333109 SGTC_1885 st057546 99.9 µM -0.0605044602676857 0.476643801914357 no 1782 0.475876931790153 2655 702008 SGTC_1028 k015-0029 4.8 µM -0.0611555297615418 0.476407236552352 no 1783 0.475617672756728 2526 4588309 SGTC_1661 st013063 9.66 µM -0.0618071157765045 0.476170491837854 no 1784 0.475358218376988 2513 721395 SGTC_73 0327-0325 16.231 µM -0.0620236102606213 0.476091833436231 no 1785 0.475272014963341 2642 53298 SGTC_1709 st033179 39.1045 µM -0.0624454943255297 0.475938554029328 no 1786 0.475104033197266 2503 573381 SGTC_2560 caryophyllene 100 µM -0.0625506189413938 0.475900360585442 no 1787 0.475062176369716 2512 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor. SGTC_1081 sertraline 6 µM -0.0626253837498171 0.475873197476881 no 1788 0.475032407889102 2523 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1 SGTC_718 1130-0073 349 µM -0.0629042403631024 0.475771885929349 no 1789 0.47492137910637 2576 6740020 SGTC_1919 st067113 52.3 µM -0.0640799287421527 0.475344763246157 no 1790 0.474453291769113 2603 1268243 SGTC_1054 3429-0080 167 µM -0.0650869372863576 0.474978943750668 no 1791 0.474052390457104 2550 1162877 SGTC_2947 9072639 7.68 µM -0.0652092710693014 0.474934504562662 no 1792 0.474003689798041 2567 16488146 SGTC_1453 4237-0541 195 µM -0.0652357905562859 0.474924871087667 no 1793 0.473993132532517 2513 739892 SGTC_840 0245-0196 390 µM -0.0667957322278063 0.474358232298183 no 1794 0.473372160506056 2640 3827528 SGTC_555 4296-0685 37 µM -0.0673226302494377 0.474166851638542 no 1795 0.473162430711242 2520 2908540 YHR072W ERG7 SGTC_2131 toluylene red 5.2905 µM -0.0674295213520673 0.474128027223967 no 1796 0.473119884011832 2538 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain. SGTC_1062 mesoridazine 14.2 µM -0.0675802774631915 0.47407327081337 no 1797 0.473059877902271 2515 4078 A neuroleptic. SGTC_1591 genipin 88.4 µM -0.068429960806872 0.473764664918018 no 1798 0.47272168622341 2677 442424 A DNA cross-linking agent. SGTC_406 estrone 100 µM -0.0689738349648363 0.473567137496896 no 1799 0.472505223279729 2544 5870 A steroid. SGTC_1226 3909-7979 35.4 µM -0.0691178645749009 0.473514829060926 no 1800 0.472447900579768 2609 6615510 SGTC_1239 0337-0584 35.4 µM -0.0693105996308166 0.473444832576131 no 1801 0.472371194372153 2602 914301 YML130C ERO1 SGTC_2286 7945697 125 µM -0.0731422789999106 0.472053436787125 no 1802 0.470846448980253 2586 1245733 SGTC_2246 7293507 91.5585 µM -0.0745811027677021 0.471531044591298 no 1803 0.470274005024257 2674 887656 SGTC_2272 7805186 180 µM -0.0765320431810232 0.470822797151851 no 1804 0.469497910975417 2533 2956062 YPR165W RHO1 SGTC_1715 st032160 10.2275 µM -0.076666722413843 0.470773908099057 no 1805 0.469444339131432 2582 5289825 SGTC_1737 st035557 69.7 µM -0.0790745847619729 0.469899920315609 no 1806 0.46848664931057 2529 5716916 SGTC_2381 9035592 200 µM -0.0793368613982625 0.469804729794224 no 1807 0.468382343768016 2575 4749657 SGTC_2306 7482397 179.52 µM -0.0799399080377892 0.469585866971396 no 1808 0.46814252467617 2597 891448 SGTC_937 3122-0005 46.7 µM -0.0804293512361076 0.469408240829479 no 1809 0.467947891802585 2547 759535 SGTC_1204 4049-0315 18.3 µM -0.0823695965091492 0.468704157503995 no 1810 0.467176406171276 2796 588402 SGTC_384 k007-0144 5.16 µM -0.0824740437615595 0.468666258058111 no 1811 0.467134879040367 2621 6824886 SGTC_2667 digitoxin 100 µM -0.0842648211622998 0.46801650589769 no 1812 0.466422940769373 2585 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_2611 pyromycin 23.93 µM -0.0851274011920466 0.467703564162969 no 1813 0.46608005318431 2592 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release. SGTC_2769 toremifene 3.73 µM -0.0855592034027755 0.467546914956699 no 1814 0.465908415227294 2660 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_2201 6605497 169.863 µM -0.0858081117373549 0.467456618272877 no 1815 0.465809479015801 2605 670741 SGTC_2141 5621638 7.665 µM -0.0887043130291418 0.466406085225476 no 1816 0.46465845237461 2668 2856238 SGTC_402 epigallocatechin gallate 10 µM -0.0887849739346968 0.466376830579157 no 1817 0.46462639979469 2567 65064 An antioxidant. SGTC_2811 7967822 32.47 µM -0.0891640518533581 0.466239346454718 no 1818 0.464475767007368 2649 2232244 SGTC_2456 5770359 74.46 µM -0.0894371805998813 0.466140290512633 no 1819 0.464367238004296 2614 3118787 SGTC_2921 7974240 10.71 µM -0.0900759074599059 0.465908650846885 no 1820 0.464113447219619 2651 2979074 YDR527W RBA50 SGTC_2450 5739737 12.93 µM -0.0901697138482872 0.46587463214224 no 1821 0.464076175555382 2622 2262825 SGTC_1074 carmofur 3.8 µM -0.0908900760918913 0.465613402501009 no 1822 0.463789967842505 2562 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_1359 1582-0056 520 nM -0.0911499862631357 0.465519153218225 no 1823 0.463686707311993 2645 3661189 SGTC_2988 9073640 71.4286 µM -0.0930190716728311 0.464841438029644 no 1824 0.462944204953782 2674 9102229 SGTC_1831 st055328 12 µM -0.0934289418911955 0.464692835982368 no 1825 0.462781399383064 2583 1103068 SGTC_1837 st055472 66.5 µM -0.0937296949337932 0.46458379845671 no 1826 0.462661940481752 2715 676091 SGTC_2568 diosmetin 100 µM -0.0938130104739835 0.464553593013421 no 1827 0.462628848201774 2559 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.  SGTC_461 N-acetylfarnesylcysteine 136 µM -0.0943776212129166 0.464348902886966 no 1828 0.462404596065889 2558 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ). SGTC_146 3448-8650 53.125 µM -0.098000627418689 0.463035669760391 no 1829 0.460965897579621 2612 2891488 YIL048W NEO1 SGTC_3276 9139060 49.47 µM -0.0989971076245783 0.462674545024503 no 1830 0.460570283302775 2566 4870619 SGTC_2116 5511452 16.8835 µM -0.0992630399123826 0.462578176268712 no 1831 0.460464711660371 2685 870744 SGTC_29 0299-0004 12.984 µM -0.0994187861166573 0.462521737853783 no 1832 0.460402883746451 2576 16871 A napthoquinone isolated from Swertia calycina. SGTC_2564 betulinic acid 100 µM -0.0997498389677418 0.462401775330903 no 1833 0.460271466023055 2649 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14 SGTC_1975 st070967 30.8 µM -0.100157984708037 0.462253881621925 no 1834 0.460109450786292 2611 261391 SGTC_2562 3',7'-dimethoxyflavone 64.92 µM -0.10153064574344 0.46175652923794 no 1835 0.459564615731218 2590 688664 SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM -0.102111940247381 0.461545928425843 no 1836 0.459333911804736 2631 4330530 SGTC_709 3807-1509 243 µM -0.104098368821926 0.460826334562362 no 1837 0.458545642659139 2566 1886677 YPL242C IQG1 SGTC_1379 2144-0755 36.5 µM -0.105732823262237 0.460234341196832 no 1838 0.457897168557244 2642 5392327 SGTC_2711 st079103 59.1 µM -0.106535715195603 0.459943568901687 no 1839 0.457578660005423 2692 54693780 SGTC_735 3076-0345 636 µM -0.106620775601299 0.45991276500027 no 1840 0.45754491799488 2673 2888990 SGTC_3179 9107801 49.47 µM -0.107489094784912 0.459598324401466 no 1841 0.457200488150041 2620 4818259 SGTC_3057 9095946 49.47 µM -0.107892802413327 0.459452140130967 no 1842 0.457040363317597 2576 24540043 SGTC_1451 4152-0210 104 µM -0.109555618664194 0.458850085212208 no 1843 0.456380904941062 2586 659563 SGTC_3192 9110362 49.47 µM -0.112547791683447 0.457766949477493 no 1844 0.455194539071367 2588 16649480 SGTC_1181 1222-0449 220 µM -0.112869401786036 0.457650548463021 no 1845 0.4550670475582 2724 658318 SGTC_975 1335-0046 28.5 µM -0.113011769590546 0.457599022146242 no 1846 0.455010612105246 2645 16486740 SGTC_805 3852-0218 479 µM -0.113475263069296 0.457431277701478 no 1847 0.454826886801754 2624 6615355 SGTC_435 c-PAF 6.7 µM -0.113769195711348 0.457324903502669 no 1848 0.454710379133804 2609 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase SGTC_2780 5215298 71.43 µM -0.114504580469128 0.457058781229331 no 1849 0.454418907796647 2662 2834131 SGTC_2036 5160441 105 µM -0.115697002257491 0.456627306603352 no 1850 0.453946341075103 2640 134534 YIL048W NEO1 SGTC_287 k060-0039 29.6 µM -0.115799763905415 0.456590124962581 no 1851 0.453905618816759 2700 5861974 SGTC_3101 9120531 49.47 µM -0.115906518165985 0.456551499100843 no 1852 0.453863314884025 2728 24824904 SGTC_3338 9144300 39.5675 µM -0.117386579208902 0.456016025388357 no 1853 0.453276859391158 2672 4901274 SGTC_3238 9133470 49.47 µM -0.11739365446821 0.456013465809751 no 1854 0.453274056152699 2706 3534688 SGTC_1607 st000305 50.6 µM -0.117427914536801 0.456001071754339 no 1855 0.453260482246125 2760 5457690 SGTC_716 1683-5115 658 µM -0.117912847554258 0.455825645100891 no 1856 0.453068356694909 2607 723597 SGTC_275 trichlorophene 5.69 µM -0.120200188442165 0.454998306140299 no 1857 0.452162284251751 2702 62616 SGTC_2095 5432005 200 µM -0.121422750482318 0.454556181104524 no 1858 0.451678098959588 2662 783734 SGTC_1126 isoteolin 1.0172 µM -0.121855854596546 0.45439956762335 no 1859 0.451506588964244 2637 133323 SGTC_2257 7960413 200 µM -0.122753490540839 0.454074998778035 no 1860 0.451151152398671 2654 2974689 YIL048W NEO1 SGTC_1647 st011722 22.4 µM -0.122874135984714 0.454031377910992 no 1861 0.451103383447181 2738 2854783 SGTC_523 1934-0222 13.7 µM -0.123374865376608 0.453850338877689 no 1862 0.45090512976091 2638 1361595 SGTC_1643 st009866 20.2 µM -0.123882546923881 0.453666796077663 no 1863 0.450704136012871 2646 3156273 YOR207C RET1 SGTC_1312 1218-2183 165 µM -0.123977112959252 0.453632608582469 no 1864 0.450666698225851 2604 6744073 SGTC_2959 9079155 11 µM -0.124288934551133 0.45351988133543 no 1865 0.450543254157902 2773 16189457 SGTC_1251 0490-5699 265 µM -0.124477805723092 0.453451603961005 no 1866 0.45046848608158 2653 3883818 SGTC_433 pimozide 108 µM -0.128831561353599 0.451878096513432 no 1867 0.448745465640406 2621 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic SGTC_1151 3909-8316 15.3 µM -0.12973805962646 0.451550569737813 no 1868 0.448386834901419 2743 800431 SGTC_2299 7976368 114.88 µM -0.130025905755104 0.451446574977382 no 1869 0.448272965423661 2723 2979718 SGTC_657 3534-0529 86.7 µM -0.1302455116115 0.451367236708594 no 1870 0.448186094082121 2763 1049549 SGTC_411 enrofloxacin 100 µM -0.130564066336708 0.451252154067358 no 1871 0.448060085119027 2762 71188 A bacterial gyrase inhibitor. SGTC_2037 5169046 200 µM -0.130870945547338 0.451141293254291 no 1872 0.447938699531923 2748 5718022 SGTC_1997 st073024 93.8 µM -0.131423063595028 0.450941848954987 no 1873 0.447720322392847 2619 686268 SGTC_850 0388-0143 75.9 µM -0.131426658924067 0.45094055023725 no 1874 0.447718900397963 2664 67273 SGTC_2620 irigenin 100 µM -0.131517858269969 0.450907607055912 no 1875 0.44768283020971 2743 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro. SGTC_2282 7944268 200 µM -0.131602357440105 0.450877084425154 no 1876 0.447649410389316 2749 2970414 SGTC_878 0828-0289 13.7 µM -0.131781347290432 0.450812431008791 no 1877 0.447578620286822 2650 745350 YLR208W SEC13 SGTC_7 0192-1582 4.227 µM -0.132354254368773 0.450605498448725 no 1878 0.447352048000714 2650 252616 SGTC_2162 5663267 200 µM -0.132717345686995 0.450474357747805 no 1879 0.447208462172816 2667 6456493 SGTC_2902 5787006 60.46 µM -0.133476063649215 0.45020034276304 no 1880 0.446908446656642 2653 591003 SGTC_1479 0549-0158 134 µM -0.133534738209682 0.450179153123973 no 1881 0.446885246573291 2689 5440202 SGTC_1731 st035964 63 µM -0.134081009531295 0.449981880377195 no 1882 0.446669258117817 2716 6739575 SGTC_1605 st000082 49.1 µM -0.134501484698844 0.449830044300519 no 1883 0.446503018569029 2770 1114022 SGTC_2602 kawain 100 µM -0.136851295490711 0.448981649514476 no 1884 0.445574168543477 2590 5369129 SGTC_2107 5363541 170.161 µM -0.137097916747127 0.448892620827765 no 1885 0.445476699558177 2651 244052 SGTC_11 0438-0307 1.3 µM -0.137155345213476 0.448871889890142 no 1886 0.445454003308009 2752 4011476 SGTC_1411 3909-8223 150 µM -0.137272908523921 0.448829451482777 no 1887 0.445407541780316 2681 X1411 SGTC_2015 5119600 184 µM -0.137767048247895 0.448651081636604 no 1888 0.44521226383509 2783 2828786 SGTC_574 1315-0397 40 µM -0.138603541670084 0.448349155891434 no 1889 0.444881722239729 2645 6794277 SGTC_3074 9116018 49.47 µM -0.14034133966327 0.447722007153646 no 1890 0.44419515159047 2626 17027303 SGTC_1738 st035555 74 µM -0.140983913085875 0.447490143753398 no 1891 0.443941325449224 2747 5331140 SGTC_3344 9148862 3.898 µM -0.142542027208943 0.446927995285075 no 1892 0.443325942675011 2782 4905352 SGTC_3013 9080133 71.4286 µM -0.142963532316728 0.446775939686564 no 1893 0.44315949114151 2823 17050193 SGTC_2336 9001819 198.65 µM -0.143113886853819 0.446721702024566 no 1894 0.443100118857668 2838 2989602 SGTC_1570 verbenone 133 µM -0.143542986516717 0.446566917617137 no 1895 0.442930682201798 2778 29025 A natural terpanoid with antifungal properties. SGTC_1280 0880-0253 10.1 µM -0.144815999710059 0.446107765541027 no 1896 0.442428074725603 2695 6836607 SGTC_2002 4023503 131 µM -0.14528363943248 0.445939114744009 no 1897 0.442243465756355 2682 4736863 YCR052W RSC6 SGTC_561 1550-0330 72.9 µM -0.145568003590702 0.445836565699733 no 1898 0.44213121415497 2685 6812934 SGTC_2565 isoliquiritigenin 100 µM -0.146980106969282 0.445327378630754 no 1899 0.441573861057938 2817 638278 Binds to benzodiazepine receptor 65X better than valium. SGTC_1920 st075728 45.7 µM -0.147422589854748 0.445167843274174 no 1900 0.441399238099373 2790 3400306 SGTC_1509 1326-1131 80 µM -0.148421967192377 0.444807554664401 no 1901 0.441004882377833 2647 768313 SGTC_1729 st035615 45.989 µM -0.14855646857811 0.444759068628911 no 1902 0.440951812396559 2818 17385451 SGTC_3347 9188721 44.724 µM -0.148867744311662 0.444646860864821 no 1903 0.440828996932085 2753 44118411 YKL104C | YBL026W GFA1 | LSM2 SGTC_43 0570-0105 72.5 µM -0.149616674455441 0.444376906913538 no 1904 0.440533525977789 2676 1114046 YDL195W SEC31 SGTC_487 nimodipine 119 µM -0.150352602799197 0.444111664629494 no 1905 0.440243216794655 2690 4497 L-type voltage-gated calcium channels inhibitor SGTC_962 1254-0300 21.5 µM -0.151034843060915 0.4438657948855 no 1906 0.439974115186305 2661 7340576 SGTC_2625 euphol 100 µM -0.152200774662805 0.443445659682798 no 1907 0.439514291495023 2780 6708538 A triterpene alcohol. SGTC_1416 3966-0321 25.3 µM -0.152759299059152 0.443244421858119 no 1908 0.439294047792336 2732 582530 YLR208W SEC13 SGTC_888 0916-0002 6.97 µM -0.153630182063419 0.442930669621953 no 1909 0.438950668801738 2848 2802138 YIL048W NEO1 SGTC_2657 nystatin 74.44 µM -0.154877993531781 0.442481184120618 no 1910 0.438458751452926 2720 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_2346 9031566 143.75 µM -0.155131664725116 0.442389815952415 no 1911 0.438358759758216 2795 4771086 SGTC_892 0929-0076 29 µM -0.156405722388488 0.441930967895899 no 1912 0.437856613436553 2702 5751038 SGTC_761 k216-0224 480 µM -0.159289726435228 0.440892591177069 no 1913 0.436720307267033 2690 1340404 SGTC_2161 5662504 8.5105 µM -0.159411929980349 0.440848601090886 no 1914 0.43667217016749 2713 2859334 SGTC_2308 7584454 197.62 µM -0.159864367020048 0.440685741924934 no 1915 0.436493959227654 2802 893577 SGTC_1475 4092-1048 11.7 µM -0.160652635889537 0.440402020767247 no 1916 0.436183497918775 2744 2881759 SGTC_3170 9103054 49.47 µM -0.16084779205413 0.440331783041375 no 1917 0.436106641327703 2752 16432970 SGTC_2643 anethole 100 µM -0.162123569910228 0.43987267026132 no 1918 0.435604272813233 2715 637563 An anti-fungal, anti-helmenthic and channel blocker. SGTC_3076 9116187 49.47 µM -0.162520418849561 0.439729873124397 no 1919 0.435448025053892 2799 27241210 SGTC_1678 st019265 80.2 µM -0.164352908464561 0.439070595060817 no 1920 0.434726666491898 2890 5367020 SGTC_2822 7994718 71.43 µM -0.165532116933799 0.438646438365858 no 1921 0.434262586423852 2661 1018011 SGTC_3212 9128307 49.47 µM -0.16653131737015 0.438287084982123 no 1922 0.433869419778367 2709 27243542 SGTC_1504 k297-0033 30 µM -0.167421614716383 0.437966940460437 no 1923 0.433519159556807 2664 4388117 SGTC_2712 st079126 47.7 µM -0.169685560547027 0.437153025177441 no 1924 0.432628715199507 2683 3152970 SGTC_373 0844-0104 25.9 µM -0.17017004085959 0.436978883203876 no 1925 0.432438205992426 2817 5375804 SGTC_559 1550-0661 158 µM -0.171461407939549 0.43651477297266 no 1926 0.431930486516856 2788 5830875 SGTC_3213 9129884 49.47 µM -0.172380523755432 0.436184500990187 no 1927 0.431569191385897 2812 17190742 SGTC_1318 1280-3875 124 µM -0.172738434867777 0.436055902439285 no 1928 0.431428515615646 2782 373245 SGTC_1682 st012968 530 nM -0.173406033382346 0.435816050337027 no 1929 0.431166141497675 2735 24207270 SGTC_2573 2',4'-dihydroxychalcone 15.04 µM -0.17345284344955 0.435799233489423 no 1930 0.431147745725362 2817 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_3173 9105693 49.47 µM -0.174480924988968 0.435429917252019 no 1931 0.430743760241186 2859 17096658 SGTC_2220 6782180 200 µM -0.174685002825822 0.435356613355546 no 1932 0.430663576294106 2713 833803 SGTC_587 k089-0003 57 µM -0.17479098680902 0.435318545232911 no 1933 0.430621935398005 2685 9659696 SGTC_1129 3453-1384 223 µM -0.175061554125094 0.435221363552736 no 1934 0.430515633537344 2947 1084452 SGTC_621 3584-0052 32.1 µM -0.175217855950315 0.435165225243418 no 1935 0.430454227176739 2739 2273927 SGTC_1000 4048-0884 8.67 µM -0.175740723252776 0.434977438563264 no 1936 0.430248820321233 2850 13040088 SGTC_946 3434-1334 87.4 µM -0.176391375260767 0.434743778762142 no 1937 0.429993239988974 2853 4047976 SGTC_2923 7992654 58.14 µM -0.178588490474414 0.43395492755514 no 1938 0.429130416234293 2760 2985126 SGTC_992 3909-8734 162 µM -0.178684776950784 0.433920362895981 no 1939 0.429092611519696 2773 4288319 SGTC_1501 4491-0275 38.4 µM -0.178766140686037 0.433891155555974 no 1940 0.429060666390046 2718 5104718 SGTC_2592 piperlongumine 83.33 µM -0.18030339844337 0.433339390368816 no 1941 0.428457193911864 2800 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_1408 3909-7976 48.8 µM -0.18122801537761 0.433007581755756 no 1942 0.428094302793981 2765 24152374 SGTC_1211 1056-0033 32.3 µM -0.181983128251477 0.432736636496926 no 1943 0.427797983256124 2747 6741922 SGTC_254 nsc-64875 3.808 µM -0.183519942532479 0.432185303434101 no 1944 0.427195036307418 2879 56993 SGTC_595 3909-8003 73.7 µM -0.183636662870038 0.432143435322994 no 1945 0.427149249693957 2836 699517 SGTC_316 k060-0003 58.6 µM -0.183907801639717 0.43204617956637 no 1946 0.427042892189575 2870 6152314 SGTC_2102 5377816 72.7585 µM -0.184938544066837 0.431676496428972 no 1947 0.426638619309659 2921 1379702 SGTC_916 4466-0038 42 nM -0.186813610288574 0.431004144164712 no 1948 0.425903387656906 2840 5722064 YGL116W CDC20 SGTC_1200 1643-0193 18.4 µM -0.187332843004405 0.43081799544502 no 1949 0.425699836891486 2726 5403974 SGTC_1334 1486-0610 236 µM -0.189233013510367 0.430136901788286 no 1950 0.424955097019523 2842 3742339 SGTC_1698 5-fluorocytosine 1.055 µM -0.190682677430852 0.429617426536198 no 1951 0.424387105538484 2835 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_1878 temozolomide 1 mM -0.191012627055186 0.429499208766469 no 1952 0.42425785017125 2763 5394 DNA alkylating agent. SGTC_1215 3852-0577 11.2 µM -0.191261873046365 0.429409910521538 no 1953 0.424160215265994 2906 2884876 SGTC_930 2810-3379 265 µM -0.191374700725616 0.429369488536218 no 1954 0.424116019817204 2954 1015764 SGTC_1163 k060-0048 49.9 µM -0.192819622828034 0.428851891992392 no 1955 0.423550117536727 2753 6809982 SGTC_2636 apigenin dimethyl ether 100 µM -0.193827065887627 0.428491080473293 no 1956 0.423155646687719 2891 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_1970 st070122 35.8 µM -0.194106457080493 0.428391028258298 no 1957 0.423046262883613 2918 102928 SGTC_1118 chelidonine 707.474 nM -0.195102490855954 0.428034378113606 no 1958 0.422656356314326 2793 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor. SGTC_1385 3091-4834 14.1 µM -0.197838844710531 0.427054874399161 no 1959 0.421585576555734 2865 4072814 SGTC_2203 7227154 166.4 µM -0.199595027178228 0.426426468764608 no 1960 0.420898658633171 2763 896304 SGTC_731 3966-0296 387 µM -0.199746447139486 0.426372295669514 no 1961 0.420839443067494 2767 660956 SGTC_271 rotenone 740 µM -0.200070938160873 0.426256208105857 no 1962 0.420712550908167 2885 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria. SGTC_648 0375-0473 33.3 µM -0.201213328333199 0.42584756575888 no 1963 0.420265885060505 2782 1713139 SGTC_3336 9143619 71.43 µM -0.20373900469203 0.424944393799049 no 1964 0.419278730045722 2769 45595730 SGTC_2854 9024559 71.43 µM -0.204316362755998 0.424737987953021 no 1965 0.419053142019912 2858 3163529 SGTC_330 1488-0319 80.1 µM -0.204496494175619 0.424673595085444 no 1966 0.418982765677248 2828 6846614 SGTC_2882 9058044 58.44 µM -0.204673931595222 0.424610167226606 no 1967 0.418913444399865 2870 18076804 SGTC_687 k029-0044 34.9 µM -0.204850186326309 0.424547164071399 no 1968 0.418844587667771 2909 5829338 SGTC_921 1561-0023 372 µM -0.205087656689231 0.424462282124012 no 1969 0.41875182000077 2739 24050882 SGTC_302 1094-0063 18.9 µM -0.2055788748008 0.424286711125674 no 1970 0.418559940259086 2763 5440289 SGTC_2225 6654152 15.4 µM -0.20578610803086 0.42421264640413 no 1971 0.418478996571679 2771 97582 YGR029W | YLR033W ERV1 | RSC58 SGTC_386 1509-0011 3.07 µM -0.206111858068817 0.424096229435206 no 1972 0.418351768119915 2758 3107280 SGTC_1123 mangostin 811.285 nM -0.206639151634539 0.423907798621724 no 1973 0.418145840761952 2864 5281650 An antioxidant. SGTC_2330 7979373 200 µM -0.206931639255879 0.423803284305086 no 1974 0.418031623355193 2784 1863007 SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM -0.210197832759614 0.422636544310669 no 1975 0.41675663549417 2858 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_1332 1480-0653 17.5 µM -0.210854125130076 0.422402187010753 no 1976 0.416500551054622 2824 5749438 SGTC_1894 3',6'-dihydroxyflavone 78.7 µM -0.211499222281644 0.422171854211688 no 1977 0.416248869507994 2915 688662 SGTC_2903 5923464 63.88 µM -0.211654282354364 0.422116493770441 no 1978 0.416188378682274 2879 2876576 SGTC_1656 st012921 11 µM -0.214493800254578 0.421102985906103 no 1979 0.415081000573731 2906 6732821 SGTC_616 4092-0450 108 µM -0.215185217861581 0.420856277390186 no 1980 0.414811457708231 2844 787165 SGTC_1813 st051246 8.6015 µM -0.216150041460981 0.420512065341363 no 1981 0.414435397051057 2851 5291959 SGTC_3263 9137018 49.47 µM -0.217288590958008 0.420105952746283 no 1982 0.413991723900247 2841 43844957 SGTC_2369 9071472 200 µM -0.217604497946112 0.419993286000782 no 1983 0.413868639808833 2941 17296037 SGTC_753 1322-0200 289 µM -0.218309376128529 0.41974191815231 no 1984 0.413594034773302 2950 5403907 SGTC_1815 st051655 58.2 µM -0.218364843620908 0.419722139180602 no 1985 0.413572427649929 2872 5984156 SGTC_2593 nobiletin 86.24 µM -0.219423921054146 0.419344525180592 no 1986 0.413159918862204 2872 72344 An anti-infammatory. SGTC_1141 3253-0389 52.6 µM -0.219458384110786 0.419332238625552 no 1987 0.413146497170456 2796 5402031 SGTC_3053 9095903 49.47 µM -0.219923787227967 0.419166323703038 no 1988 0.412965255140458 2826 17174018 SGTC_584 0986-0246 15.4 µM -0.220175585157742 0.419076564428257 no 1989 0.412867205152291 2780 53315 YDR232W HEM1 SGTC_2746 daunorubicin 9.88 µM -0.221148183957897 0.418729898380214 no 1990 0.412488526765952 2773 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_2848 9016370 25.97 µM -0.221274156112646 0.418685002390997 no 1991 0.412439485840453 2847 7894410 SGTC_2370 9071495 200 µM -0.222342083333219 0.418304439860368 no 1992 0.412023797053379 2880 21791103 SGTC_1787 fluconazole 80 µM -0.223038397889687 0.418056344981645 no 1993 0.411752810965548 2839 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C SGTC_1897 st060201 15 µM -0.224350925869994 0.417588783752752 no 1994 0.411242126425917 2827 611878 SGTC_2605 digitonin 300 nM -0.224635490219326 0.417487428870201 no 1995 0.411131426599098 2852 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_2899 9053889 58.44 µM -0.225878262725037 0.41704484794051 no 1996 0.410648052382166 2867 6470052 SGTC_1085 doxorubicin 7.67 µM -0.226079053650533 0.416973351350779 no 1997 0.410569967811139 2897 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_3180 9109287 49.47 µM -0.226210591055537 0.416926515683297 no 1998 0.410518816814049 2928 18891271 SGTC_1996 st072960 66.8 µM -0.226413411575065 0.416854301012033 no 1999 0.410439948910032 2859 1719405 SGTC_3064 1327-0027 10 µM -0.227185672016739 0.416579361760444 no 2000 0.41013968425177 2804 16000455 YPR107C YTH1 SGTC_856 0433-0016 11.3 µM -0.227243015054521 0.416558948185561 no 2001 0.41011739064991 2875 3911780 SGTC_3007 9078383 71.4286 µM -0.227288369597779 0.416542802559836 no 2002 0.410099758093789 2848 6496995 SGTC_333 3486-0131 40.1 µM -0.227919407501505 0.416318175917833 no 2003 0.409854447382582 2962 6744690 SGTC_56 0957-0365 83.25 µM -0.228506308719575 0.416109284863447 no 2004 0.40962632610155 2893 6752360 SGTC_462 ag-879 158 µM -0.229138752941637 0.415884210578916 no 2005 0.40938053706182 2930 6809654 Ag-879 is a 5-Lipoxygenase inhibitor. SGTC_389 tpck 16.7 µM -0.232748973534777 0.414599935438863 no 2006 0.407978168979111 2894 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.  SGTC_1562 morin hydrate 59.1 µM -0.234132697572091 0.414107940033654 no 2007 0.40744098115399 3003 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase. SGTC_2797 7859098 81.82 µM -0.235852732929108 0.413496554096464 no 2008 0.406773473612568 2845 972681 SGTC_968 1309-0633 340 µM -0.236855947008043 0.41314005873137 no 2009 0.406384273381505 2921 3761976 SGTC_442 cape 100 µM -0.237349467458485 0.412964710904436 no 2010 0.406192844395814 2960 5281787 SGTC_2447 5741742 33.78 µM -0.239086548124995 0.412347664441857 no 2011 0.405519236190675 2907 1776504 SGTC_1765 st044815 90.4 µM -0.239918673459643 0.41205215319513 no 2012 0.405196652128108 2915 645695 SGTC_1490 4089-0339 670 nM -0.244363571519765 0.410474492646054 no 2013 0.403474626195729 2856 742542 SGTC_2322 7413319 38.22 µM -0.245268741650806 0.410153390497197 no 2014 0.403124176604835 2968 1840400 SGTC_2844 9010103 25.97 µM -0.246598091083021 0.409681923239963 no 2015 0.402609641014336 3037 2480525 SGTC_1281 0884-0031 11.8 µM -0.248466566374509 0.409019470407296 no 2016 0.401886717643703 2836 1548255 SGTC_2435 5706476 10.6 µM -0.249223781816914 0.408751079648385 no 2017 0.401593842233549 3005 5725375 SGTC_1420 4'-methoxyflavone 42 µM -0.250634273194815 0.408251253069783 no 2018 0.401048440555406 2912 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13 SGTC_1015 4130-4525 82 µM -0.250692536858353 0.408230609761616 no 2019 0.401025915595412 2871 1363237 SGTC_424 splitomicin 100 mM -0.251907314745656 0.40780026179092 no 2020 0.400556352765324 2927 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_585 0kpi-0023 191 µM -0.252859574481306 0.40746299140083 no 2021 0.400188364680663 2990 64601 SGTC_2108 5365811 200 µM -0.253580883622228 0.407207564495459 no 2022 0.399909683330061 2969 780283 SGTC_3240 9133527 49.47 µM -0.253705655957445 0.407163384650001 no 2023 0.399861482088924 2883 17617455 SGTC_2173 5763948 167 µM -0.254105156444545 0.40702193600202 no 2024 0.39970715991318 2828 2867177 SGTC_1102 cgs 12066b 26.1 µM -0.255029642777965 0.406694655415706 no 2025 0.399350102203291 2893 6438352 A 5-HT1B full agonist. SGTC_2188 6126565 140.678 µM -0.255290172737122 0.406602436067558 no 2026 0.399249494780934 2964 874518 SGTC_536 3852-0578 10.6 µM -0.256821212344575 0.40606060138891 no 2027 0.398658397042185 3026 2869208 SGTC_1429 4049-0205 9.46 µM -0.257676160893921 0.405758113431039 no 2028 0.398328422902799 2859 22774478 SGTC_195 4234-0266 16.654 µM -0.258146232492184 0.405591822122073 no 2029 0.398147026014206 2890 2303354 SGTC_1267 0828-0272 9.49 µM -0.260455302250495 0.404775219531441 no 2030 0.397256294691713 2999 745334 SGTC_1850 st056238 17 µM -0.260712943155834 0.404684130459822 no 2031 0.397156941986538 2824 5393177 SGTC_2199 6590217 200 µM -0.262237555793047 0.404145208774077 no 2032 0.39656915044026 2926 703109 SGTC_581 0958-0271 211 µM -0.262297274663491 0.404124102979402 no 2033 0.396546131498623 2874 4591145 SGTC_656 4090-1979 187 µM -0.263731200570056 0.403617409986122 no 2034 0.395993525927985 2992 22330961 SGTC_509 pifithrin 175 µM -0.264324175910914 0.40340792305097 no 2035 0.395765066426667 2939 4817 A p53 inhibitor. SGTC_3111 9122088 49.47 µM -0.26509899040349 0.403134237565732 no 2036 0.39546660253228 2919 16876704 SGTC_2195 6536160 144.242 µM -0.267597045776012 0.402252180387922 no 2037 0.394504752594138 2867 3834386 SGTC_774 k060-0086 136 µM -0.267987055862391 0.402114513576943 no 2038 0.394354641181251 3001 5911235 SGTC_1503 4585-0012 61.3 µM -0.270849336020875 0.401104550816263 no 2039 0.393253456444684 3072 2922052 SGTC_957 1187-1561 14.1 µM -0.273155534649269 0.400291282955946 no 2040 0.392366829394594 2855 1538454 SGTC_1843 st055809 45.5 µM -0.274163086270189 0.399936111028818 no 2041 0.391979647247078 3036 16413835 SGTC_1725 st036284 20.55 µM -0.274334491931501 0.399875697064742 no 2042 0.391913790077351 3126 707914 SGTC_2495 cafestol 54.53 µM -0.274672997124619 0.399756393924375 no 2043 0.391783739329379 3088 16667697 An anti-infammatory. SGTC_1972 st070201 17.4 µM -0.274807824002353 0.399708877997396 no 2044 0.391731943383164 3030 2829099 SGTC_1038 k292-0204 154 µM -0.275719111876098 0.39938775928857 no 2045 0.391381907633455 2868 4454212 SGTC_2271 7849410 118.62 µM -0.27752557571264 0.398751400741164 no 2046 0.390688285100047 2963 972430 SGTC_2241 6772625 37.8075 µM -0.277920071723091 0.398612468344152 no 2047 0.390536857820803 2847 2285411 SGTC_3195 9113082 49.47 µM -0.278367214563322 0.398455010482669 no 2048 0.390365242131453 2967 17018038 SGTC_279 1273-0055 2.93 µM -0.279219382414858 0.398154972015964 no 2049 0.390038234959407 2957 2847562 SGTC_112 phenothiazine 287.218 µM -0.280959248033348 0.397542572544645 no 2050 0.389370828331782 3041 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.  SGTC_2031 5180455 200 µM -0.283318281534821 0.39671264122005 no 2051 0.388466432263617 2897 29949 SGTC_1694 st024011 44.9 µM -0.283514404279642 0.396643664303371 no 2052 0.388391270715954 2955 2787533 SGTC_1954 st077032 68.9 µM -0.284548079665464 0.396280171277319 no 2053 0.387995196891913 2978 698907 SGTC_432 NS 1619 61.3 µM -0.28789939155999 0.395102300391492 no 2054 0.386711876335894 3090 4552 A K+/calcium channel activator. SGTC_575 k072-0246 11.9 µM -0.289313804195195 0.394605469808308 no 2055 0.386170624792246 2901 6796779 SGTC_2727 riluzole 51.77 µM -0.291014536114671 0.394008292887554 no 2056 0.38552010110457 2935 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.  SGTC_2433 5607874 27.82 µM -0.292146299720643 0.393611035408556 no 2057 0.385087383965423 2915 2252428 SGTC_292 k038-0015 474 µM -0.292602087613213 0.393451081701085 no 2058 0.384913158946185 3045 46368540 SGTC_2638 epoxomicin 18 µM -0.295194158405688 0.392541765848095 no 2059 0.383922782096761 3029 9915668 A protesome inhibitor. SGTC_31 0508-1974 57.237 µM -0.295523178115195 0.392426385354231 no 2060 0.383797124496777 3039 6810525 SGTC_2159 5658611 73.75 µM -0.295697285574651 0.39236533324819 no 2061 0.383730635168833 3030 793844 SGTC_3206 9114350 49.47 µM -0.296366387784455 0.392130732129528 no 2062 0.383475145786068 3052 17087243 SGTC_794 k038-0031 316 µM -0.296466078811996 0.39209578174046 no 2063 0.383437084187849 2926 6624242 SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM -0.297229503114134 0.391828163901349 no 2064 0.383145649445281 3008 279621 SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM -0.297369293408123 0.391779166053965 no 2065 0.383092292113326 2952 1241132 A phosphatase inhibitor. SGTC_79 0052-0007 94.094 µM -0.298720061548689 0.39130579732058 no 2066 0.382576824340445 3093 2801472 SGTC_2475 5812728 15.03 µM -0.300038342500591 0.390843968701933 no 2067 0.382073954532615 2909 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2 SGTC_172 1112-0046 2.638 µM -0.300837057678806 0.390564232521929 no 2068 0.381769374329227 2963 2802135 YIL048W NEO1 SGTC_404 fumagillin 50 µM -0.301562188828037 0.390310316919367 no 2069 0.381492917859793 2992 12015870 A methionine aminopeptidase binder. SGTC_3105 9121040 49.47 µM -0.303880097271238 0.389498980613082 no 2070 0.38060962064271 2919 41448907 SGTC_3061 glucosamine 200 µM -0.304631790393885 0.389235969054472 no 2071 0.380323302446987 3044 91431 and experimental redox chemotherapeutic SGTC_3220 9131269 49.47 µM -0.305866502755457 0.388804063001467 no 2072 0.379853145671111 2933 17722206 SGTC_169 k015-0017 16.025 µM -0.306343696626758 0.388637175951555 no 2073 0.379671486155926 3175 1840002 SGTC_393 acivicin 6.25 µM -0.30635747480454 0.388632357671234 no 2074 0.379666241434404 2927 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1 SGTC_103 0844-0104 51.839 µM -0.306382582914379 0.388623577315344 no 2075 0.379656683983357 3058 5375804 SGTC_102 gallobenzophenone 83.616 µM -0.309234626464204 0.387626583392417 no 2076 0.378571527865808 3125 70837 SGTC_223 busulfan 5 mM -0.310249630713222 0.387271944876335 no 2077 0.378185565675318 3034 2478 A DNA alkylator. SGTC_2770 toltrazuril 17.5 µM -0.310384720625675 0.387224752075232 no 2078 0.378134205983124 2975 68591 Kills coccidiodes. SGTC_1063 disulfiram 1.84 µM -0.310403734447015 0.387218109851557 no 2079 0.378126977311181 2957 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_1896 st058441 89 µM -0.311108994324172 0.386971760108209 no 2080 0.377858881869165 2997 688759 SGTC_499 genistein 192 µM -0.312019971173568 0.386653620099326 no 2081 0.377512672845686 3014 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger. SGTC_1978 st071761 42 µM -0.312109280542572 0.38662243472698 no 2082 0.377478736869381 2969 5147680 SGTC_1304 1165-0502 251 µM -0.313983467285841 0.385968168528761 no 2083 0.37676679773235 2974 767425 SGTC_2354 9060492 162 µM -0.314623877275106 0.385744679860504 no 2084 0.376523623879425 3113 6471895 SGTC_460 trequinsin 123 µM -0.319322900907665 0.384105990859238 no 2085 0.374740834287747 3047 5537 A vasodilator. SGTC_682 0kpi-0099 17 µM -0.319479753127764 0.384051327369201 no 2086 0.374681371128358 3049 1714895 YML126C ERG13 SGTC_823 0417-1665 178 µM -0.320520760637208 0.383688591492823 no 2087 0.374286797552752 3058 3429856 SGTC_2998 9066762 71.4286 µM -0.32148759328414 0.383351792878046 no 2088 0.373920456401195 3162 4945196 SGTC_2513 baicalein 25.65 µM -0.321895347240778 0.383209777157348 no 2089 0.373765989057766 3021 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2 SGTC_1713 st033146 12.748 µM -0.322358354984349 0.383048536246424 no 2090 0.37359061478645 3121 674619 SGTC_3232 9132874 49.47 µM -0.32238493765242 0.383039279535214 no 2091 0.373580546815874 2982 3784940 SGTC_2680 butyl paraben 22.24 µM -0.322431899718167 0.383022926400902 no 2092 0.373562760524082 3002 7184 An antifungal and steroid mimetic. SGTC_2245 6637752 200 µM -0.326298636241192 0.38167716892892 no 2093 0.372099209967698 3102 681890 SGTC_2451 5856223 45.7 µM -0.326716485448396 0.381531828277576 no 2094 0.371941165175816 3012 2179896 SGTC_1256 0570-0116 285 µM -0.327748892256152 0.38117279747378 no 2095 0.371550766339907 3010 410638 SGTC_1010 4112-3296 15.2 µM -0.328380776148432 0.380953103337011 no 2096 0.371311888128404 3148 704384 SGTC_1030 k029-0042 36.7 µM -0.329216254882637 0.380662682023125 no 2097 0.370996118758866 3035 6080581 SGTC_1744 st037937 38.9 µM -0.329465441569442 0.380576075084387 no 2098 0.370901955400483 3182 1016152 SGTC_1232 0279-0259 161 µM -0.330654040704863 0.380163049839145 no 2099 0.370452910720165 3033 1560000 SGTC_2968 9090663 33.37 µM -0.330890573261073 0.38008087363746 no 2100 0.370363571359291 3041 25236811 SGTC_1910 st062352 60.4 µM -0.331353195675108 0.379920164890268 no 2101 0.370188857104683 2929 2245730 SGTC_2345 9052315 157.45 µM -0.331743256846942 0.379784679043695 no 2102 0.370041567179335 3075 6469265 SGTC_3228 9131799 49.47 µM -0.332410029777643 0.379553112895183 no 2103 0.369789833032937 3049 17015818 SGTC_605 1315-0399 119 µM -0.332844981762347 0.379402080012877 no 2104 0.369625650867541 3138 24020461 SGTC_1875 nocodazole 6 µM -0.333428503419424 0.379199486652414 no 2105 0.369405425157225 3108 4122 A microtubule depolymerizer. YJL014W CCT3 SGTC_138 0850-0259 40.9225 µM -0.333568973044782 0.379150721840467 no 2106 0.369352417200051 3073 6813004 SGTC_2715 st079500 56.4 µM -0.334355679108889 0.378877648018405 no 2107 0.369055589832475 2962 28246688 SGTC_2962 9082311 13.18 µM -0.334778409992528 0.378730938709348 no 2108 0.368896124001371 2945 16459453 SGTC_1402 3909-7673 35.9 µM -0.334881678989687 0.378695101722907 no 2109 0.368857171495968 2943 5328014 SGTC_3197 9113331 49.47 µM -0.335899799192571 0.378341843818226 no 2110 0.368473214244474 3229 16610459 YLR208W | YDL195W SEC13 | SEC31 SGTC_2531 methyl deoxycholate 70.07 µM -0.336049795484713 0.378289808080913 no 2111 0.368416658175999 2973 16667744 Haematoxylin. SGTC_624 k048-0052 28 µM -0.336301156823479 0.378202612390743 no 2112 0.368321888831219 3040 6835531 SGTC_3275 9138069 49.47 µM -0.336820365537902 0.378022521750103 no 2113 0.368126159873495 3097 17617007 SGTC_2035 5154463 94.595 µM -0.337620189446614 0.377745149925684 no 2114 0.367824712854884 3155 2769623 SGTC_2551 apiole 73.87 µM -0.33820462644899 0.377542512210062 no 2115 0.367604494835861 2946 10659 A possible DNA adduct former. SGTC_1622 st003707 19.4 µM -0.338214872554606 0.377538959950657 no 2116 0.367600634453472 3128 10140899 SGTC_1086 cerivastatin 2.18 µM -0.338671992321068 0.377380489990397 no 2117 0.367428420966894 3055 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7 SGTC_2364 9055074 200 µM -0.338875699397227 0.377309877394494 no 2118 0.367351685756709 3078 6470630 SGTC_2635 hydroquinidine 100 µM -0.338985256970647 0.377271902281869 no 2119 0.367310418278898 2967 442912 An experimental heart treatment. SGTC_188 3229-0966 278.469 µM -0.340252945585837 0.376832579370374 no 2120 0.366833024647419 3125 5722370 SGTC_1940 st075990 51.1 µM -0.3409503709069 0.376590951588652 no 2121 0.366570471862961 3269 1084979 SGTC_114 0364-0001 490.298 µM -0.341804784200159 0.376295000144765 no 2122 0.366248904470241 3059 4003655 SGTC_192 3455-0609 60.9 µM -0.342273332577575 0.376132735346637 no 2123 0.366072601232081 3139 3769639 SGTC_2752 diclazuril 33.15 µM -0.343437201170484 0.375729766314155 no 2124 0.365634788494491 3125 456389 An antifungal agent for coccidioides. YHR062C RPP1 SGTC_18 0111-0177 500 nM -0.344598869622427 0.375327694157233 no 2125 0.365197977854001 3031 721752 SGTC_123 0083-0120 66.675 µM -0.344660118253144 0.375306498773828 no 2126 0.365174951987462 3026 16001701 SGTC_3261 9137475 49.47 µM -0.344899899367918 0.375223524987308 no 2127 0.365084813131727 3051 17027690 SGTC_3262 9137218 49.47 µM -0.348405403487296 0.374011142360647 no 2128 0.363767872524518 2929 17650664 SGTC_1345 1488-0192 31.4 µM -0.350083198855288 0.373431314764891 no 2129 0.363138129711642 3168 658348 SGTC_1393 3470-5649 58.2 µM -0.350416408935233 0.373316195083275 no 2130 0.363013106781459 3084 4108395 SGTC_579 4491-1009 110 µM -0.352672217506489 0.372537140868779 no 2131 0.362167094958411 3150 1271041 SGTC_200 k038-0079 37.545 µM -0.352983244082177 0.37242976717692 no 2132 0.362050501155951 3010 3436683 SGTC_2068 5226020 147 µM -0.353379168209221 0.372293099197801 no 2133 0.361902100526336 3068 1810509 SGTC_1288 0973-0013 65.5 µM -0.35397834165147 0.372086302727756 no 2134 0.361677557300338 3135 4315430 SGTC_2295 7971645 200 µM -0.354949391313024 0.371751236655477 no 2135 0.361313752766716 3059 2978226 YKL099C UTP11 SGTC_1268 0828-0275 2.46 µM -0.355027269597886 0.37172436852507 no 2136 0.361284581031553 3121 745337 SGTC_2042 p-Dimethylaminoacetophenone 200 µM -0.355674430235545 0.371501121270578 no 2137 0.361042198088995 3087 75037 A free radical scavenger. SGTC_2668 2',4'-dihydroxychalcone 15.08 µM -0.356572079606511 0.371191535927041 no 2138 0.360706091248295 3082 5357218 A potent inhibitor of glutathione S-transferases. SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM -0.357350892782119 0.3709230028487 no 2139 0.36041456737964 3041 6708784 An antioxidant flavonoid SGTC_572 0960-0087 17.7 µM -0.357441613088221 0.370891726770147 no 2140 0.360380614399181 3063 6796365 SGTC_2633 5,7-dihydroxyisoflavone 100 µM -0.35804253038909 0.37068458040032 no 2141 0.360155742909682 3181 5377381 SGTC_2418 pentamidine 31.67 µM -0.360592006863971 0.369806150166733 no 2142 0.359202232736513 3137 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_83 0170-0301 39.027 µM -0.360953002288415 0.369681822813104 no 2143 0.35906729029267 3051 3089716 SGTC_2775 cyproheptadine 69.59 µM -0.361845314194608 0.369374567761199 no 2144 0.358733813757275 3146 2913 A selective serotonin reuptake inhibitor. SGTC_2673 kobusone 100 µM -0.362654009111935 0.369096177092495 no 2145 0.358431679714386 3063 6710676 An epoxy ketone and protein crosslinker. SGTC_1263 0774-1208 64.8 µM -0.363469156831193 0.368815634538248 no 2146 0.35812722451932 3219 906585 SGTC_2194 5927483 104.545 µM -0.365130284286994 0.368244154692468 no 2147 0.357507077818096 3030 760979 SGTC_158 k038-0087 26.446 µM -0.365445323406019 0.368135804208374 no 2148 0.357389507019674 2995 X158 SGTC_2825 7998094 58.44 µM -0.365470780204968 0.368127049383753 no 2149 0.357380007278727 3088 2987815 SGTC_2940 9060638 45.86 µM -0.365514999145124 0.368111842250983 no 2150 0.357363506259536 3142 4027022 SGTC_217 ketoconazole 989 nM -0.365962416204033 0.36795798473194 no 2151 0.357196560288099 3130 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4 SGTC_763 3453-1109 128 µM -0.366852010937665 0.367652134356069 no 2152 0.356864704560608 3212 1560353 SGTC_1184 1269-1718 139 µM -0.368271600639056 0.367164240985364 no 2153 0.356335363093129 3195 5403821 SGTC_2755 lomerizine 42.69 µM -0.368569661303172 0.367061828862736 no 2154 0.356224256324384 3092 3949 A calcium channel blocker. SGTC_634 1611-4317 11.2 µM -0.370404868267368 0.366431469782248 no 2155 0.35554042350793 3165 2843522 SGTC_248 streptozotocin 5.23457 mM -0.370675228059808 0.366338636676273 no 2156 0.355439721560644 3146 5300 DNA alkylating agent. SGTC_3077 9117319 49.47 µM -0.372606398468992 0.365675760846517 no 2157 0.354720704983314 3075 17154678 SGTC_2122 5258151 111.688 µM -0.373991019998886 0.36520073500613 no 2158 0.354205498606252 3064 2173356 SGTC_2430 5571206 200 µM -0.374630098291356 0.364981554385434 no 2159 0.353967792699156 3218 1731771 SGTC_77 0828-0286 12.516 µM -0.37469281157179 0.364960048385669 no 2160 0.353944469486916 3152 745345 SGTC_1979 st071809 45.3 µM -0.375344188163887 0.364736699700479 no 2161 0.353702253467206 3191 4976333 SGTC_2061 5245884 80.95 µM -0.375448475798952 0.364700945067673 no 2162 0.353663479345153 3047 573863 SGTC_3236 9132701 49.47 µM -0.375786861088488 0.364584939018976 no 2163 0.353537678218212 3137 24282524 SGTC_198 3454-2873 16.191 µM -0.376276132758397 0.364417227670928 no 2164 0.353355810515916 3078 710957 SGTC_1839 st053978 48 µM -0.377827284675653 0.363885699304966 no 2165 0.352779451653576 3162 3788398 SGTC_2490 carminic acid 95.39 µM -0.378469382984767 0.363665750046222 no 2166 0.352540967040627 3088 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_2743 auranofin 4.32 µM -0.379711594507926 0.363240361004365 no 2167 0.352079756257409 3094 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold. SGTC_2196 6573537 42.6665 µM -0.380143203726308 0.363092598060687 no 2168 0.351919558403594 3188 2903087 SGTC_3046 9092212 49.47 µM -0.381325784931639 0.362687841655981 no 2169 0.351480761430612 3138 25236637 SGTC_486 niguldipine 82 µM -0.383364786699123 0.361990322736413 no 2170 0.350724654357305 3075 1236 A calcium channel blocker. SGTC_1748 st037455 53.6035 µM -0.38390477318086 0.361805676241636 no 2171 0.350524514233617 3251 580690 SGTC_1810 st050138 53 µM -0.384388333265681 0.361640351855977 no 2172 0.350345323148861 3216 3444541 SGTC_882 0843-0131 351 µM -0.386346714236772 0.360971065234221 no 2173 0.349619954039067 3219 5425421 SGTC_324 1315-0088 19.6 µM -0.386408581612535 0.360949928667295 no 2174 0.349597047770342 3155 6787421 SGTC_875 0709-0210 25.7 µM -0.386552403163422 0.360900794656496 no 2175 0.349543800252953 3230 6251364 SGTC_1024 4507-0395 26 µM -0.386834015009054 0.360804593752124 no 2176 0.349439546763315 3244 4201836 SGTC_1230 0170-0365 3.77 µM -0.387167966490378 0.360690524615295 no 2177 0.349315931713934 3213 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1 SGTC_2204 7233102 200 µM -0.389532674926299 0.359883156863178 no 2178 0.348441072221349 3088 2172480 SGTC_2313 7726885 200 µM -0.39027150439151 0.359631030821923 no 2179 0.348167896089761 3162 726423 SGTC_2966 9084041 48.03 µM -0.390540563043718 0.359539229546755 no 2180 0.348068433417319 2985 17741380 SGTC_3039 9090270 49.47 µM -0.390743407135416 0.359470025659874 no 2181 0.347993455131601 3246 17173750 SGTC_2606 farnesol 9.78 µM -0.39408897765108 0.358329290912075 no 2182 0.346757674235245 3247 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_635 k038-0028 24.7 µM -0.394610176977705 0.358151691740194 no 2183 0.346565300846611 3128 4035102 SGTC_2144 5628481 200 µM -0.394668596862322 0.358131787020295 no 2184 0.346543740675862 3117 2818399 SGTC_1634 st006576 41 µM -0.395910343894228 0.357708792447025 no 2185 0.346085584970845 3274 3915356 SGTC_1948 st076329 66.6 µM -0.39641265614435 0.357537732026938 no 2186 0.345900315487963 3056 24208413 SGTC_2101 5377231 179.231 µM -0.396472026156818 0.357517515697914 no 2187 0.345878420287408 3206 2844213 SGTC_3038 9091290 49.47 µM -0.396660699229337 0.35745327250233 no 2188 0.3458088425419 3263 25236843 SGTC_3065 9113888 49.47 µM -0.399464135237927 0.35649917913751 no 2189 0.344775622522684 3290 16648368 SGTC_725 1497-0963 19 µM -0.39995530231421 0.356332112462321 no 2190 0.344594719359841 3215 3549977 SGTC_1443 4112-3303 14 µM -0.400091640094552 0.356285743109984 no 2191 0.344544510697777 3116 704433 SGTC_3349 9149703 23.001 µM -0.400870113786472 0.356021019944351 no 2192 0.344257877260724 3095 4910494 SGTC_2491 paeonol 100 µM -0.400959692127081 0.355990562912577 no 2193 0.344224900316965 3058 11092 Increases levels of cortical cytochrome oxidase. SGTC_986 1493-0483 84 µM -0.403044787859983 0.355281881167443 no 2194 0.343457638217967 3224 40079 SGTC_3330 9141424 71.43 µM -0.407365592549982 0.353814921809006 no 2195 0.341869747013739 3239 27261020 SGTC_182 3448-4371 550.524 µM -0.407691311059612 0.353704424495434 no 2196 0.341750158680981 3199 3491403 SGTC_876 0720-0963 56.8 µM -0.408958767915093 0.353274567589428 no 2197 0.341284960068551 3293 765861 SGTC_276 colchicine 750 µM -0.410205261667426 0.352852002788928 no 2198 0.340827690725091 3260 2833 A microtubule depolymerizer. SGTC_1398 3558-0053 112 µM -0.410828722635422 0.352640715851643 no 2199 0.340599065174583 3047 4532369 SGTC_754 3474-0146 171 µM -0.411290924911394 0.352484107787289 no 2200 0.340429611600162 3091 24762078 SGTC_1380 2291-0730 164 µM -0.411557007547289 0.35239396230743 no 2201 0.340332074429184 3188 2999191 SGTC_2160 5660466 132.927 µM -0.412158024752638 0.352190375690993 no 2202 0.340111800542951 3222 2859134 SGTC_1574 spiramycin 23.7 µM -0.412601848063 0.35204006360598 no 2203 0.339949173518132 3079 6419898 An antibiotic and protein synthesis inhibitor. SGTC_2459 5811157 9.22 µM -0.416241357835962 0.350808324701291 no 2204 0.338616699508378 3194 2870684 YBR192W RIM2 SGTC_2806 7952793 58.44 µM -0.41729381446647 0.350452427532631 no 2205 0.338231756159856 3269 2972490 SGTC_463 ikarugamyin 104 µM -0.417845563432016 0.350265901340497 no 2206 0.338030017639733 3211 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis. SGTC_63 0099-0242 26.702 µM -0.41873861038487 0.349964071292199 no 2207 0.337703587335487 3247 3898502 YLR359W ADE13 SGTC_2351 9026858 72.31 µM -0.418754632271217 0.349958657115083 no 2208 0.337697732061539 3071 1409300 SGTC_2762 leflunomide 42.06 µM -0.421991880771986 0.348865340818574 no 2209 0.336515471884441 3144 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1 SGTC_10 0279-0212 42.575 µM -0.422023412655096 0.348854697702944 no 2210 0.336503964195265 3176 39851 YBR002C RER2 SGTC_2202 7226349 200 µM -0.424042305752633 0.348173498428647 no 2211 0.335767480132836 3126 844334 SGTC_2794 7785382 27.27 µM -0.424656364258378 0.347966404556058 no 2212 0.335543598948358 3268 2205081 SGTC_1079 idarubicin 2.36 µM -0.426701807348314 0.347276897428097 no 2213 0.334798266992915 3257 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_2892 9047358 58.44 µM -0.426842804792585 0.347229386584367 no 2214 0.334746913347264 3186 6466771 SGTC_2377 9073351 62.6 µM -0.429783478498999 0.346239038153347 no 2215 0.333676576075707 3133 7337946 YHR072W ERG7 SGTC_583 1488-1091 88.9 µM -0.430099189074327 0.346132776723982 no 2216 0.333561744949518 3257 4303273 SGTC_2060 5238662 140 µM -0.430971304357309 0.345839304337267 no 2217 0.333244617810771 3233 790130 SGTC_2809 7964133 12.99 µM -0.431394629153498 0.345696886197938 no 2218 0.333090727234002 3179 1253665 SGTC_1688 st021091 57.6 µM -0.432112825346505 0.345455315138702 no 2219 0.332829706827564 3277 3656366 SGTC_1424 4048-1941 275 µM -0.433731154105354 0.34491120806086 no 2220 0.332241840305453 3289 X1424 SGTC_1903 st060211 78.3 µM -0.433756797875782 0.344902588807034 no 2221 0.332232528386176 3300 688960 SGTC_3097 9117246 49.47 µM -0.434941327317755 0.344504538578453 no 2222 0.331802507945249 3237 16423892 SGTC_829 1635-0120 117 µM -0.436391862379667 0.344017334086466 no 2223 0.331276221056252 3294 285054 SGTC_551 k048-0028 34.9 µM -0.436395585310751 0.344016083964209 no 2224 0.331274870720847 3297 6836383 SGTC_2171 5739187 198.077 µM -0.436734173960908 0.343902396481759 no 2225 0.331152071218263 3088 2262761 SGTC_1387 3342-1166 1.8 µM -0.437056737310932 0.343794102919384 no 2226 0.331035100668131 3208 3418228 SGTC_2460 5552655 174.22 µM -0.437364947144924 0.343690640207252 no 2227 0.330923350511679 3283 5401989 SGTC_2384 9036245 200 µM -0.438257644122228 0.343391037558053 no 2228 0.330599763105414 3197 6462766 SGTC_3188 9110789 49.47 µM -0.440245495381154 0.342724238199774 no 2229 0.329879656021857 3327 849217 SGTC_697 0508-1955 564 µM -0.440394748187011 0.342674192988451 no 2230 0.329825613989918 3327 6243113 SGTC_835 0312-0010 67.2 µM -0.441332784970709 0.342359727808781 no 2231 0.32948604736561 3145 1626196 SGTC_630 4356-0227 183 µM -0.442265439946444 0.342047175130021 no 2232 0.329148568279515 3246 779312 SGTC_2096 5468907 200 µM -0.442936325266961 0.341822413969527 no 2233 0.328905895998547 3258 759785 SGTC_2718 lomofungin 53.02 µM -0.442936777314351 0.341822262542717 no 2234 0.328905732508503 3307 5351222 A RNA synthesis inhibitor. SGTC_644 1498-1197 63.3 µM -0.443431229927196 0.341656646077124 no 2235 0.328726925556019 3289 6741615 SGTC_185 k048-0037 25.491 µM -0.444179190941856 0.341406175124846 no 2236 0.328456517868794 3301 6827589 SGTC_910 3454-3003 490 µM -0.446130481486688 0.340753072187932 no 2237 0.327751497865414 3312 820824 SGTC_2013 4024628 200 µM -0.446145073021018 0.340748190151296 no 2238 0.327746228112222 3313 5230760 SGTC_3116 9124943 49.47 µM -0.447253514370163 0.34037740579302 no 2239 0.327346013307861 3203 41905195 YPL160W CDC60 SGTC_1196 1588-0294 184 µM -0.447345088685198 0.340346780191987 no 2240 0.327312958270774 3217 6144269 SGTC_2875 9039966 71.43 µM -0.447621410089946 0.340254375191869 no 2241 0.327213224381353 3224 6463691 SGTC_2857 9024691 58.44 µM -0.448888027456297 0.339830926862572 no 2242 0.32675621660725 3259 16478292 SGTC_1076 itraconazole 331 nM -0.449484276344881 0.339631662220176 no 2243 0.326541174139372 3264 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1 SGTC_3027 9089541 49.47 µM -0.449637276774041 0.339580537145539 no 2244 0.326486002461121 3286 9943819 SGTC_2474 5321570 43.32 µM -0.450568981422074 0.339269271897298 no 2245 0.326150113414261 3267 2841384 SGTC_49 0717-0965 32.132 µM -0.45307953033121 0.338431090341584 no 2246 0.32524573725809 3438 5889349 YGL099W LSG1 SGTC_730 1436-0052 41.2 µM -0.453147447516736 0.338408426341327 no 2247 0.325221285682557 3280 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2 SGTC_970 1315-0089 19.5 µM -0.453487182746681 0.338295065306559 no 2248 0.32509898535174 3273 6811083 YLR033W RSC58 SGTC_782 0083-0095 30.5 µM -0.455116943942576 0.337751459249362 no 2249 0.324512554375224 3187 3591729 An indicator and reagent. SGTC_1111 tnp00062 510.699 nM -0.455726797382964 0.337548129846279 no 2250 0.324293224784046 3348 676306 SGTC_93 0109-0045 59.227 µM -0.457304430657333 0.337022355990464 no 2251 0.323726122769617 3306 88733 SGTC_3248 9135562 49.47 µM -0.459268593766307 0.336368209120147 no 2252 0.323020648985707 3260 17650701 SGTC_683 panaxydol 45 µM -0.45957986264423 0.336264589208282 no 2253 0.322908908035158 3253 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis. SGTC_315 k915-0449 187 µM -0.46086089195814 0.335838271710002 no 2254 0.322449205691833 3270 20970215 YNL149C PGA2 SGTC_1351 1496-0003 46.5 µM -0.46141402037144 0.33565425972127 no 2255 0.322250797245399 3334 3891978 SGTC_394 menadione 8.33 µM -0.461684051050038 0.335564441579008 no 2256 0.322153955003223 3300 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_861 0443-0273 110 µM -0.462241202110319 0.335379150578919 no 2257 0.321954179724394 3296 6149169 SGTC_475 α-linolenic acid 10 µM -0.463427917572493 0.33498461967093 no 2258 0.321528835764102 3434 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_738 1315-0003 72.4 µM -0.464250197486856 0.334711354347247 no 2259 0.321234250355125 3348 6251474 SGTC_1624 st003710 6.25 µM -0.464521413342874 0.334621241344535 no 2260 0.321137110728157 3304 24207033 SGTC_854 0422-0053 192 µM -0.464625897472243 0.334586528442667 no 2261 0.321099691589079 3306 3596728 SGTC_592 k241-0073 46.5 µM -0.465178115218719 0.33440308789272 no 2262 0.320901954768838 3336 4230158 SGTC_2521 angolensin 13.4 µM -0.467071586797658 0.333774398243381 no 2263 0.320224330879227 3339 821428 A flavenoid. SGTC_1841 st054148 70 µM -0.468564483802228 0.333279040125336 no 2264 0.319690484377983 3276 675442 SGTC_2062 5245942 200 µM -0.471632766320557 0.332261866685484 no 2265 0.318594467303463 3330 1376160 SGTC_681 1642-0006 26.6 µM -0.471819201786838 0.332200100739449 no 2266 0.318527921936997 3326 4446530 SGTC_2113 5491891 107.031 µM -0.472054167027015 0.332122263403722 no 2267 0.318444062926935 3264 789979 SGTC_1147 3809-1045 12.3 µM -0.47221057537843 0.332070453757449 no 2268 0.318388245998379 3245 325925 SGTC_1703 st026983 48.3 µM -0.473154354412657 0.331757898849321 no 2269 0.318051530233604 3356 1104023 SGTC_1009 4106-0057 9.87 µM -0.473172752702963 0.331751806979941 no 2270 0.318044967696154 3370 2928005 SGTC_2600 tangeritin 87.95 µM -0.473297348665569 0.331710553103957 no 2271 0.318000526718556 3246 68077 A bioactive flavone. SGTC_1341 1486-1360 280 µM -0.473716577775821 0.33157176081987 no 2272 0.317851015024333 3208 3976547 SGTC_1205 4161-2785 76 µM -0.473880915643379 0.331517360533179 no 2273 0.317792414519212 3311 3498106 SGTC_2279 7948423 32.93 µM -0.474078976516479 0.331451801740711 no 2274 0.317721794942668 3387 1247112 SGTC_1335 1486-0900 202 µM -0.474363184517356 0.331357736990863 no 2275 0.317620470769211 3273 X1335 SGTC_777 1315-0167 517 µM -0.476915606458758 0.330513435440827 no 2276 0.316711109175608 3286 4221767 SGTC_2832 7992762 51.95 µM -0.477448340964146 0.330337323710476 no 2277 0.316521449112918 3123 2985177 SGTC_1008 4106-0037 6 µM -0.482123890104947 0.328793293178567 no 2278 0.314858969839435 3277 2905394 SGTC_2223 6903751 107.57 µM -0.482168283017542 0.328778647022067 no 2279 0.314843203001448 3312 5598863 SGTC_2405 ticlatone 3.52 µM -0.482223444227392 0.328760448543963 no 2280 0.314823612104294 3039 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W SGTC_3247 9135149 49.47 µM -0.482799256280477 0.328570504097635 no 2281 0.314619139466634 3276 8934436 YOR116C RPO31 SGTC_2886 9058944 51.95 µM -0.483191016144017 0.328441298683224 no 2282 0.314480056815324 3214 4949929 SGTC_2846 9008642 19.48 µM -0.483436571262284 0.328360323175224 no 2283 0.314392893217323 3344 2992898 SGTC_821 1114-0266 29.2 µM -0.48362369032992 0.328298623249836 no 2284 0.314326479347899 3314 3123235 SGTC_2744 captopril 92.04 µM -0.484156140072215 0.328123080936549 no 2285 0.314137530705425 3301 44093 angiotensin-converting enzyme (ACE) inhibitor  SGTC_196 k015-0023 18.111 µM -0.484227868336155 0.328099435885614 no 2286 0.314112080460027 3235 5211998 SGTC_3010 9080089 71.4286 µM -0.484805940739757 0.327908900850873 no 2287 0.313907004126741 3324 17027233 SGTC_1872 amphotericin b 148 nM -0.485140536342383 0.327798637227463 no 2288 0.313788329610456 3323 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1 SGTC_649 1123-0311 367 µM -0.487421724897012 0.327047288089077 no 2289 0.312979750506797 3312 693629 YIL048W NEO1 SGTC_2298 7976326 193.81 µM -0.487600423825633 0.326988460034907 no 2290 0.312916447655729 3273 2235818 SGTC_786 4544-0069 423 µM -0.4879257169506 0.326881383906833 no 2291 0.312801228990944 3324 748821 YLR208W SEC13 SGTC_2859 9028643 45.46 µM -0.48810578859339 0.326822116190133 no 2292 0.312737455566074 3297 17151580 SGTC_2900 5328528 85.29 µM -0.489524840373764 0.32635521084734 no 2293 0.312235086337537 3320 795359 SGTC_3196 9111891 49.47 µM -0.489955671949778 0.326213509718751 no 2294 0.312082633400247 3333 18891510 SGTC_71 0417-1750 47.813 µM -0.490446354396013 0.326052154106641 no 2295 0.311909040984693 3385 6811472 SGTC_2719 novobiocin 32.65 µM -0.490950800920573 0.325886306272997 no 2296 0.311730622692616 3384 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication. SGTC_2678 equilin 100 µM -0.491489452603243 0.325709250772247 no 2297 0.311540155114902 3376 3247 Equilin is an estrone commonly used hormone replacement therapy SGTC_2767 sibutramine 71.45 µM -0.492287576036327 0.325446978853354 no 2298 0.311258030871048 3436 64765 A serotonin-norepinephrine reuptake inhibitor.  SGTC_606 k015-0008 38.6 µM -0.492430878441057 0.32539989729331 no 2299 0.311207387427422 3381 1970475 SGTC_629 3448-6466 76.7 µM -0.492622165249482 0.325337054948479 no 2300 0.311139791739369 3329 573744 SGTC_2170 morpholine 200 µM -0.493491369446919 0.325051562914298 no 2301 0.310832718270109 3367 121171 Reacts with secondary amines. SGTC_3050 9093513 49.47 µM -0.494251004687556 0.324802143122931 no 2302 0.310564461278367 3336 25236664 SGTC_1360 1598-0022 39.8 µM -0.494753791910493 0.324637100380234 no 2303 0.310386962768734 3352 761525 SGTC_939 1165-0479 45.3 µM -0.495013163939969 0.324551973507031 no 2304 0.310295414159963 3371 1377347 SGTC_3312 9133330 71.43 µM -0.49526858056972 0.324468153767645 no 2305 0.310205273144995 3375 17617324 SGTC_863 0466-0191 129 µM -0.498655970707514 0.323357360711467 no 2306 0.309010883725113 3369 765160 YPR165W RHO1 SGTC_2393 9031399 185.94 µM -0.498768954671912 0.323320338056726 no 2307 0.308971080405872 3405 1526623 YDL150W RPC53 SGTC_1166 k206-0078 225 µM -0.500008028580686 0.322914432427301 no 2308 0.308534712146778 3333 5404595 SGTC_2626 ethyl orsellinate 100 µM -0.50263949644294 0.322053095190347 no 2309 0.307608877561238 3264 75653 A natural product. SGTC_3157 9099274 49.47 µM -0.504016642116893 0.321602705499409 no 2310 0.307124841157085 3406 17217662 SGTC_2969 9091408 28.7 µM -0.505508504787305 0.321115093827049 no 2311 0.306600863259906 3228 4286311 SGTC_1809 st050081 57.6 µM -0.505642245851202 0.321071395931482 no 2312 0.306553909475486 3448 5036894 SGTC_1907 st060210 83.7 µM -0.507096775357413 0.320596310252093 no 2313 0.306043458743051 3419 688793 SGTC_130 0136-0219 337.655 µM -0.507778360361295 0.320373788587505 no 2314 0.305804393622985 3307 234244 SGTC_416 estradiol valerate 100 µM -0.507910001842403 0.320330818140196 no 2315 0.305758230060998 3377 13791 A steroid. SGTC_1571 st070080 73.4 µM -0.508952481321017 0.31999061682306 no 2316 0.305392766149045 3438 4315245 SGTC_472 calcifediol 10 µM -0.509120649279897 0.319935751289638 no 2317 0.305333829354621 3351 5283731 A vitamin D metabolite. SGTC_1250 0485-0349 40.2 µM -0.512870629786064 0.318713328681563 no 2318 0.304020909696809 3282 6842794 YDL195W SEC31 SGTC_1084 voriconazole 435 nM -0.513718540295462 0.318437198533722 no 2319 0.303724393786302 3403 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_2533 agelasine 13.65 µM -0.513992019507113 0.318348158916435 no 2320 0.303628785121634 3478 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase. SGTC_2319 6033012 152.6 µM -0.51476598055626 0.318096228835638 no 2321 0.303358280247034 3259 847246 SGTC_380 3970-0968 6 µM -0.515021168629634 0.31801318165788 no 2322 0.303269113820537 3268 2891601 SGTC_645 0845-0943 5.41 µM -0.515549478465105 0.317841280133741 no 2323 0.303084551922649 3330 1885106 SGTC_2817 7995342 71.43 µM -0.515915016855445 0.317722364175116 no 2324 0.302956882677681 3235 18879975 SGTC_493 zm226600 134 µM -0.516751025360298 0.317450466836131 no 2325 0.302664985871185 3450 5240098 A potassium channel opener. YCR052W RSC6 SGTC_3244 9134489 49.47 µM -0.516752208864319 0.317450081991634 no 2326 0.302664572733806 3372 16584271 SGTC_116 0155-0182 31.788 µM -0.516894840400454 0.31740370339825 no 2327 0.302614784791969 3306 771486 SGTC_1792 st045773 43.6 µM -0.516936308365319 0.317390220060531 no 2328 0.30260031038853 3336 2919270 SGTC_1579 chlormadinone acetate 49.4 µM -0.517241083602772 0.317291129615311 no 2329 0.302493938037674 3417 45114258 A steroidal progestin. SGTC_510 ag-490 170 µM -0.517490213909071 0.317210140527378 no 2330 0.302406999280026 3450 5328779 SGTC_1871 st057448 67.3 µM -0.518111721510807 0.317008134488712 no 2331 0.302190161248557 3507 691747 SGTC_2145 5634607 200 µM -0.519270522755449 0.316631639770569 no 2332 0.301786053104367 3298 308662 SGTC_1397 3532-0190 20.1 µM -0.520846918913036 0.31611977330058 no 2333 0.301236707663179 3274 5322280 SGTC_1544 7-methoxy-4-methylcoumarin 105 µM -0.520893769832268 0.316104565876221 no 2334 0.301220387862467 3301 390807 SGTC_1922 5578187 25 µM -0.521801615106915 0.315809948191184 no 2335 0.300904232516082 3480 1350412 SGTC_807 1315-0151 48 µM -0.523355427372753 0.315305970159535 no 2336 0.300363467975128 3492 4011080 SGTC_2400 5203494 178.7 µM -0.52349642776781 0.315260253755166 no 2337 0.300314418140841 3389 6777674 SGTC_1502 4534-4282 27.7 µM -0.524019659330216 0.315090631685262 no 2338 0.300132433127674 3341 3278949 SGTC_1020 4335-0961 93.3 µM -0.52450661470854 0.314932804709519 no 2339 0.299963110144428 3237 669075 SGTC_1491 4138-0063 26.5 µM -0.525227352081001 0.314699268735606 no 2340 0.299712576406864 3378 23883227 SGTC_2788 5282734 71.43 µM -0.525228823001806 0.314698792198174 no 2341 0.299712065200641 3443 743706 SGTC_914 3820-6779 408 µM -0.526031606867353 0.314438758617651 no 2342 0.299433123331736 3303 2893481 SGTC_788 1182-0090 188 µM -0.526448226253588 0.314303845697423 no 2343 0.299288407751744 3479 5715185 SGTC_2303 7774051 200 µM -0.527988652329543 0.313805228483022 no 2344 0.29875360601971 3447 2953184 SGTC_2291 7917025 104.35 µM -0.528196009040435 0.313738135567659 no 2345 0.298681649556258 3285 2964612 SGTC_1399 3562-5772 25 µM -0.530362521381148 0.31303750151378 no 2346 0.297930303009032 3360 23847490 SGTC_2366 9070441 60.58 µM -0.531780481556038 0.312579308738629 no 2347 0.297439021374011 3326 6837235 SGTC_19 0279-0214 38.434 µM -0.532081565507355 0.312482055173108 no 2348 0.297334752249638 3429 3566274 YBR002C RER2 SGTC_2172 5754775 163.918 µM -0.533089958458127 0.312156427835655 no 2349 0.296985654892251 3306 2263357 SGTC_3342 9147791 14.508 µM -0.533459318265322 0.312037191927845 no 2350 0.296857832492441 3386 1838168 SGTC_1933 st074711 15.9 µM -0.534013505369027 0.311858327423801 no 2351 0.296666095128197 3391 17250958 SGTC_693 4161-2696 114 µM -0.535525225203901 0.311370643821645 no 2352 0.296143359676834 3395 805759 SGTC_1626 st003712 1.76 µM -0.537603632339932 0.310700686046089 no 2353 0.295425361000969 3436 24207035 SGTC_427 1354-0053 47.3 µM -0.539099366066188 0.310218936285906 no 2354 0.294909146496998 3504 6813657 SGTC_2197 6588183 93.1375 µM -0.539870971968714 0.309970542687621 no 2355 0.294643008953453 3387 884136 SGTC_1905 st060207 84.5 µM -0.542486964143638 0.309129054344256 no 2356 0.293741542663403 3352 1948547 SGTC_190 3970-0790 3.722 µM -0.542814398940501 0.309023798484367 no 2357 0.293628799141169 3419 2832352 SGTC_2591 skatole 100 µM -0.542860731683815 0.309008905814871 no 2358 0.293612847303041 3439 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite. SGTC_1899 st063254 59.6 µM -0.543695197371615 0.308740738425473 no 2359 0.293325618937487 3344 3093813 SGTC_2444 5485484 36.41 µM -0.544164668075743 0.308589912156698 no 2360 0.293164081411754 3463 6790631 SGTC_542 3381-0244 89.3 µM -0.545326910279818 0.30821665900627 no 2361 0.292764349623542 3484 1112843 SGTC_1422 4031-0024 15.5 µM -0.545838972588479 0.308052273487862 no 2362 0.292588315580911 3394 782427 SGTC_1437 4092-1038 11.6 µM -0.546615879143031 0.307802939503719 no 2363 0.29232132875194 3378 3977136 SGTC_1648 st011736 69.8 µM -0.546641648592499 0.307794670788741 no 2364 0.292312474926443 3488 2855514 SGTC_2008 4012253 172 µM -0.549942650620628 0.306736277390637 no 2365 0.291179354715763 3376 603940 SGTC_3198 9112019 49.47 µM -0.550343561514344 0.306607843590773 no 2366 0.29104187561158 3426 45595555 SGTC_2324 6149169 200 µM -0.552368247935923 0.305959588240601 no 2367 0.290348040184868 3344 2888231 SGTC_2340 7987427 183.45 µM -0.552703529343157 0.305852297848936 no 2368 0.290233218115163 3428 2239331 SGTC_3143 9086658 49.47 µM -0.552803472989821 0.305820319003063 no 2369 0.290198995053181 3430 25236626 SGTC_1464 k208-0027 110 µM -0.554718076136514 0.305207991857765 no 2370 0.289543755100049 3502 X1464 SGTC_111 0083-0039 52.457 µM -0.554753358858767 0.305196712867485 no 2371 0.289531686717767 3396 759313 SGTC_1623 st003709 20.3 µM -0.555302709664654 0.30502112323454 no 2372 0.289343812886582 3420 16192618 SGTC_2018 5133068 143 µM -0.55578237189653 0.304867844940063 no 2373 0.289179818881059 3417 785362 SGTC_3011 9081274 71.4286 µM -0.556325281013509 0.304694397116271 no 2374 0.288994253836848 3389 6625322 SGTC_1629 st005085 44.9 µM -0.556747430249652 0.304559559817078 no 2375 0.288850002958308 3358 24207091 SGTC_3291 9121177 71.43 µM -0.560041448488702 0.30350834136282 no 2376 0.287725583180568 3384 17015612 SGTC_675 1309-0189 238 µM -0.560509810980414 0.303359004748243 no 2377 0.287565874785603 3392 4246530 SGTC_3090 9117696 49.47 µM -0.560677292740313 0.303305611434525 no 2378 0.287508774829379 3369 7923821 SGTC_686 1319-0111 510 µM -0.563478119959987 0.30241332882147 no 2379 0.286554677529875 3520 4562600 SGTC_885 0865-0106 16.8 µM -0.564890709411231 0.301963755593461 no 2380 0.286074051649225 3436 2793380 SGTC_1999 st074831 12.5 µM -0.565559032301601 0.30175115863858 no 2381 0.28584679197514 3379 17112523 SGTC_1808 st050063 61.5 µM -0.568215262701388 0.300906864076531 no 2382 0.284944404499206 3476 4011993 SGTC_2143 5623677 140.463 µM -0.570290813422476 0.300247883518345 no 2383 0.284240235319058 3454 5375313 SGTC_448 monastrol 171 µM -0.571813768318539 0.299764765700702 no 2384 0.283724074294715 3428 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity SGTC_2339 9000433 200 µM -0.573323573114746 0.299286167205281 no 2385 0.283212813608625 3381 2988954 SGTC_1880 MG-132 525 µM -0.574932236225115 0.298776613035872 no 2386 0.282668563600058 3477 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1 SGTC_653 0203-0016 55.2 µM -0.575349165505268 0.29864461242806 no 2387 0.282527588304741 3439 295302 SGTC_711 k292-0785 179 µM -0.575794399470434 0.29850367978963 no 2388 0.282377079749009 3497 4146315 SGTC_443 clozapine 122 µM -0.577417404797299 0.29799019632375 no 2389 0.281828759748003 3430 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_1852 st056254 31.4 µM -0.577617279698999 0.297926988119375 no 2390 0.281761269034901 3389 442583 SGTC_538 2922-0838 53.3 µM -0.581139048443751 0.296814272257576 no 2391 0.280573371529036 3532 777039 SGTC_2642 cholecalciferol 100 µM -0.583490114923526 0.296072504572661 no 2392 0.279781704802099 3469 9821465 A vitamin D precursor, similar to steriods. SGTC_1498 4478-3555 97.6 µM -0.58355250684304 0.296052831350395 no 2393 0.279760710550254 3488 3437919 SGTC_1258 0671-0043 57.1 µM -0.58392373965026 0.295935787805998 no 2394 0.279635810259719 3452 4298767 SGTC_398 bronopol 33.3 µM -0.584440793336512 0.295772804772332 no 2395 0.279461894036031 3424 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them. SGTC_855 0428-0020 25 µM -0.585692180080141 0.295378519790691 no 2396 0.279041195026094 3464 6812414 SGTC_309 k408-0051 1.48 µM -0.585963765163968 0.295292981132729 no 2397 0.278949932547706 3475 3640463 SGTC_233 rapamycin 362 pM -0.586260972598727 0.295199385504705 no 2398 0.278850076668507 3499 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C SGTC_2501 sodium tetradecyl sulfate 13.37 µM -0.587062904773357 0.294946911719705 no 2399 0.278580729976388 3422 23665772 A membrane-active detergent. SGTC_2248 tofa 1.1 µM -0.587438265890183 0.294828770282843 no 2400 0.278454700177416 3436 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_2792 7535235 81.82 µM -0.587538338474758 0.294797277046724 no 2401 0.278421104883929 3415 1281891 SGTC_26 0302-0163 425.158 µM -0.587770128569332 0.294724337749034 no 2402 0.278343298388726 3452 3100915 SGTC_759 3486-0358 89.3 µM -0.591462644826102 0.293563507244214 no 2403 0.277105238569285 3550 875103 SGTC_2865 9030313 51.95 µM -0.591765745363411 0.293468314462537 no 2404 0.277003732119295 3420 42562754 SGTC_2112 5488546 200 µM -0.594052374598715 0.292750629186065 no 2405 0.276238541627788 3439 600757 SGTC_3335 9143315 29.6265 µM -0.595929061821659 0.292162218641496 no 2406 0.275611308817094 3438 4899691 SGTC_2610 ononetin 44.17 µM -0.596007653776012 0.292137589180336 no 2407 0.275585056830731 3480 259632 SGTC_1923 st058458 19.1 µM -0.596215490753292 0.292072461053334 no 2408 0.275515639193662 3571 3534982 SGTC_1060 3448-7350 82 µM -0.596888839400568 0.291861505876738 no 2409 0.275290799549221 3502 570178 SGTC_3146 9095609 49.47 µM -0.597997474757301 0.291514333289006 no 2410 0.274920809022998 3482 17173999 SGTC_899 1083-0020 478 µM -0.59928730992689 0.291110659978838 no 2411 0.274490654379944 3569 767123 SGTC_225 nsc-122657 1.016 µM -0.601097333017301 0.290544626673554 no 2412 0.273887579812774 3484 275685 SGTC_353 1988-1175 58.3 µM -0.601858270748819 0.290306818879853 no 2413 0.273634241649932 3394 2788357 SGTC_1144 3486-0183 12.5 µM -0.603771025624349 0.289709448814664 no 2414 0.27299794273511 3483 6744069 SGTC_3110 9122132 49.47 µM -0.603866007134718 0.289679800298873 no 2415 0.272966365220285 3595 918317 SGTC_2189 6047310 154.431 µM -0.604305942082044 0.289542493009443 no 2416 0.272820128248796 3495 711535 SGTC_46 0329-0187a 2.197 µM -0.604316780019973 0.289539110786263 no 2417 0.272816526144842 3499 46494817 SGTC_880 0833-0487 87.2 µM -0.604599715039185 0.289450821091439 no 2418 0.272722498029648 3507 76075 SGTC_1221 2958-7315 257 µM -0.605429533078278 0.28919194985425 no 2419 0.272446816437616 3530 4562705 SGTC_824 1304-0008 100 µM -0.606493485427247 0.288860197073612 no 2420 0.272093553499905 3510 768245 SGTC_1270 0831-1170 17.3 µM -0.606925887284155 0.288725420330802 no 2421 0.271950048694714 3542 6764716 SGTC_251 melphalan 456.522 µM -0.606987557009871 0.288706200706194 no 2422 0.271929584917116 3560 460612 A DNA alkylator. SGTC_3270 9137563 49.47 µM -0.610526485642883 0.287604289642082 no 2423 0.270756552015806 3482 17015724 SGTC_436 n,n-dimethylsphingosine 3.3 µM -0.61385940344727 0.286568345158481 no 2424 0.269654119391633 3656 5282309 SGTC_3148 9097893 49.47 µM -0.614677780982107 0.286314246271274 no 2425 0.269383768081498 3442 17174100 SGTC_933 2914-0560 114 µM -0.616549649252879 0.285733450441588 no 2426 0.268765907065231 3571 463887 SGTC_274 sirtinol 40.1 µM -0.617001680242824 0.285593280122907 no 2427 0.268616808724892 3530 6836442 NAD-dependent acetyltransferase inhibitor. SGTC_1162 k048-0130 20.1 µM -0.621184757993696 0.284297704413636 no 2428 0.26723903343465 3537 6797406 SGTC_2217 6934799 96.0675 µM -0.621252207421702 0.284276837126075 no 2429 0.267216846948592 3518 675606 SGTC_1480 1070-0044 41.2 µM -0.623673136849965 0.283528342922468 no 2430 0.266421134213781 3539 3124987 SGTC_2320 7373003 200 µM -0.62386594093873 0.283468773076694 no 2431 0.266357814808907 3546 5415828 SGTC_1988 st071872 53.4 µM -0.624338788588022 0.283322704784438 no 2432 0.26620255765148 3574 16414116 SGTC_1618 st003135 44.5 µM -0.625393324891528 0.282997075980382 no 2433 0.265856471038359 3508 1270615 SGTC_562 3772-2733 112 µM -0.62631302967267 0.282713228368667 no 2434 0.265554820836497 3566 2876874 YIL048W NEO1 SGTC_1486 3970-0793 4.53 µM -0.627578878812733 0.282322774415615 no 2435 0.265139924273058 3580 2844330 SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM -0.627642408444263 0.282303185400219 no 2436 0.265119110387434 3573 4213774 SGTC_399 oxolinic acid 75 µM -0.628284641761177 0.282105192991107 no 2437 0.264908745407547 3509 4628 A DNA gyrase inhibitor. SGTC_2696 st077691 74.316 µM -0.628816802699355 0.281941185172128 no 2438 0.264734499177618 3547 757133 SGTC_547 1120-0019 610 nM -0.629058797353921 0.281866619517284 no 2439 0.264655281797197 3532 3676939 SGTC_133 0724-0033 378.92 µM -0.63094531290203 0.281285654726029 no 2440 0.264038141203981 3474 280309 SGTC_3239 9133757 49.47 µM -0.631252421358522 0.281191133412128 no 2441 0.263937745487877 3563 17036923 SGTC_862 0452-0056 10.2 µM -0.631392489456587 0.281148028586975 no 2442 0.263891962793667 3521 1575396 YLR359W | YHR072W ADE13 | ERG7 SGTC_2058 5236698 133 µM -0.633429311165026 0.280521574068345 no 2443 0.263226664517615 3552 766665 SGTC_803 4488-1585 147 µM -0.634227187361062 0.280276359776274 no 2444 0.262966283562988 3541 747204 SGTC_1040 k898-0338 155 µM -0.634450878997193 0.280207630423515 no 2445 0.262893307101771 3616 20969351 SGTC_1968 st069590 43.6 µM -0.635219476021293 0.279971540898774 no 2446 0.262642641344573 3542 6384066 SGTC_3184 9108758 49.47 µM -0.635521658753818 0.27987874601558 no 2447 0.262544122731597 3572 902885 SGTC_2660 2',4'-dihydroxychalcone 17.14 µM -0.637854791913444 0.279162785409368 no 2448 0.261784104265299 3583 5357218 A potent inhibitor of glutathione S-transferases. SGTC_245 methotrexate 289.6 µM -0.638907558144237 0.278840018395392 no 2449 0.261441535414558 3558 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2 SGTC_1838 st055369 84.5 µM -0.640036097416893 0.278494221970184 no 2450 0.261074565920341 3557 676036 SGTC_1175 0741-0056 27.6 µM -0.640662751709683 0.278302298689264 no 2451 0.260870909820587 3630 765927 SGTC_14 0354-0009 295 µM -0.640831625553619 0.278250589301819 no 2452 0.260816041566208 3606 1713507 SGTC_1524 corynanthine 62.1 µM -0.641033905748566 0.278188657013509 no 2453 0.260750327177961 3606 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist. SGTC_1365 1672-3266 55.4 µM -0.641525896831335 0.278038051776304 no 2454 0.260590530523579 3579 6415873 SGTC_1445 4239-0156 97.7 µM -0.641536008626967 0.27803495683383 no 2455 0.260587246783266 3635 4008346 SGTC_647 0140-0236 81 µM -0.642537814079504 0.277728415096453 no 2456 0.260262022564584 3596 990837 SGTC_2445 5742597 35.57 µM -0.642781929712883 0.277653743346016 no 2457 0.260182805033199 3529 1774255 SGTC_1564 D-Arginine 115 µM -0.643415229528618 0.277460071027208 no 2458 0.259977351987858 3534 71070 D-isomer of arginine; arginine decarboxylase inhibitor. SGTC_269 exalamide 29 µM -0.643545068914848 0.277420372407929 no 2459 0.259935240258405 3544 3316 A derivative of salicylamide. SGTC_199 4063-0024 41.6 µM -0.647525020558652 0.276204844146849 no 2460 0.258646103255814 3623 306215 SGTC_2961 9083290 32.55 µM -0.648819502008021 0.275810056992441 no 2461 0.258227525254804 3571 17741490 SGTC_310 1273-0058 1.06 µM -0.651002341275568 0.275144969721869 no 2462 0.257522487768285 3623 2734232 SGTC_2347 9049783 174.81 µM -0.652904091141315 0.274566171798044 no 2463 0.256909055653689 3599 6467988 YPL169C MEX67 SGTC_2929 9013348 24.6 µM -0.653757412561358 0.274306658633397 no 2464 0.256634053975111 3591 2995952 SGTC_282 k297-0036 65.7 µM -0.659295500313388 0.272625357925056 no 2465 0.254853015662829 3619 5061378 SGTC_3139 9095020 49.47 µM -0.659730034602844 0.272493654966261 no 2466 0.254713544512002 3440 25236292 SGTC_3016 9080866 49.47 µM -0.661427170777867 0.271979572966539 no 2467 0.254169202982982 3612 17066299 SGTC_771 0250-0039 27.3 µM -0.661451951453894 0.271972070190239 no 2468 0.254161259320194 3593 3005115 SGTC_2938 9059746 27.26 µM -0.663445240761387 0.271368904905878 no 2469 0.253522719668961 3580 6471769 SGTC_3324 9138759 60.749 µM -0.66464002979788 0.27100768396414 no 2470 0.253140379757669 3631 45595710 SGTC_2463 5473429 200 µM -0.665867464610806 0.270636843166117 no 2471 0.252747909047597 3566 5399405 SGTC_2091 4-phenylthiadiazole 200 µM -0.666566955613401 0.270425621702169 no 2472 0.25252439110267 3620 270010 SGTC_1733 st037357 54.9 µM -0.668692372578153 0.269784327090178 no 2473 0.251845867029185 3593 1272339 YGL099W LSG1 SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM -0.671798723225272 0.268848430662761 no 2474 0.250855920838391 3580 279621 SGTC_2139 5578692 56.4705 µM -0.671960052041205 0.268799869307087 no 2475 0.250804564152632 3579 650991 YMR113W FOL3 SGTC_3287 9117173 37.0625 µM -0.675996694949974 0.267586241242675 no 2476 0.249521371726673 3610 2789709 SGTC_1755 st041960 45.185 µM -0.676761794932635 0.267356523577092 no 2477 0.249278550972587 3647 2257073 SGTC_1537 2',6'-dihydroxyflavanone 78 µM -0.676873104934502 0.267323111565126 no 2478 0.249243234847728 3647 5106787 A p450 inhibitor. SGTC_1573 oleylamine 1.06 µM -0.677085541262873 0.267259350230777 no 2479 0.249175841030843 3658 5356789 An amine of the fatty acid oleic acid. SGTC_1158 4092-0494 91.8 µM -0.677996716474524 0.266985954204328 no 2480 0.248886887562741 3707 1148199 SGTC_1786 berberine 21.6 µM -0.678804610100543 0.266743665777227 no 2481 0.248630836184389 3621 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_1338 1486-1223 76 µM -0.680396605280647 0.266266549677454 no 2482 0.24812668496789 3661 3444526 SGTC_479 n-linoleoylglycine 10 µM -0.681448640485289 0.265951495145733 no 2483 0.247793827128493 3641 6433346 An anti-infammatory. SGTC_1788 fluconazole 20 µM -0.682074845956495 0.265764054179019 no 2484 0.247595812587611 3620 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11 SGTC_1794 st048918 76.9 µM -0.685587538663726 0.264713849076364 no 2485 0.246486620901074 3587 672303 SGTC_997 3996-0078 137 µM -0.6864314011474 0.264461870576344 no 2486 0.246220554341359 3687 735687 SGTC_868 0527-0199 213 µM -0.687901106306576 0.264023306208866 no 2487 0.245757529930086 3616 2849450 SGTC_1530 rhein 70.4 µM -0.688156029661432 0.263947274059443 no 2488 0.245677265003886 3696 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death. SGTC_358 0075-0058 9.45 µM -0.688374000920228 0.263882271906995 no 2489 0.245608645945593 3658 1069125 SGTC_1003 4049-0218 100 µM -0.688488035365032 0.263848268453495 no 2490 0.245572751111669 3678 295161 SGTC_3109 9122853 49.47 µM -0.688686910788669 0.263788971969631 no 2491 0.245510157468338 3689 1234709 SGTC_1867 st057372 64 µM -0.688748667993729 0.263770559890191 no 2492 0.245490721876426 3658 688837 SGTC_2639 lactacystin 53 µM -0.690173075290845 0.263346073984877 no 2493 0.245042676573453 3685 3870 A proteasome inhibitor. SGTC_502 l-744,832 89.3 µM -0.692169844131371 0.262751607076384 no 2494 0.244415337011584 3629 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.  SGTC_973 1325-0077 65.9 µM -0.693352908250919 0.262399715919363 no 2495 0.244044053728462 3703 2835149 SGTC_1130 3454-2858 15.9 µM -0.694254079956462 0.262131832985982 no 2496 0.24376144153502 3674 715628 YIL048W NEO1 SGTC_1191 1487-1166 10.6 µM -0.69712056522039 0.261280672427234 no 2497 0.242863672553544 3733 3955771 SGTC_3135 9127742 49.47 µM -0.698083975048376 0.26099492121074 no 2498 0.242562339579681 3683 3643468 SGTC_2010 4012422 159 µM -0.698792952745136 0.260784738267635 no 2499 0.242340716659297 3664 952393 SGTC_2975 9084847 53.72 µM -0.700864527775125 0.260171100207575 no 2500 0.241693781725333 3708 27211724 SGTC_1840 st055363 71 µM -0.701692623969825 0.25992601148791 no 2501 0.241435436969304 3640 676033 SGTC_1847 st056231 15 µM -0.70263080073896 0.259648486562784 no 2502 0.241142931227218 3687 5393180 SGTC_971 1315-0384 26.7 µM -0.702783006547311 0.25960347652474 no 2503 0.241095494508874 3683 6769120 SGTC_1693 xanthone 101.9 µM -0.703746623681977 0.259318610845193 no 2504 0.240795289741522 3735 7020 An insecticide. SGTC_1313 1220-0047 237 µM -0.703751908907539 0.259317048865819 no 2505 0.240793643746216 3698 3528706 SGTC_912 3474-0017 2.18 µM -0.705781578803868 0.258717566052845 no 2506 0.240161989765752 3716 3360550 SGTC_326 k292-0812 17.5 µM -0.706372567937874 0.258543146588729 no 2507 0.239978237829735 3658 3579357 SGTC_3096 9117468 49.47 µM -0.707162501296428 0.258310107565109 no 2508 0.239732749388045 3613 41316311 SGTC_1568 digitonin 820 nM -0.707605627428805 0.258179428160907 no 2509 0.239595098620427 3688 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1 SGTC_1630 st005209 31.3 µM -0.70801634745607 0.258058336040265 no 2510 0.239467552879858 3679 3367314 SGTC_539 4859-0462 2.54 µM -0.708045434328777 0.258049761507487 no 2511 0.239458521595784 3710 46499474 YNL221C | YBR257W POP1 | POP4 SGTC_2553 4-methylesculetin 85.09 µM -0.708890088868906 0.257800829862303 no 2512 0.239196343013618 3722 5319502 SGTC_742 0kpi-0133 140 µM -0.709219711945527 0.257703719096547 no 2513 0.239094071431137 3700 2728852 SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM -0.709407224122709 0.257648484318813 no 2514 0.239035903019247 3692 6312947 SGTC_3054 9094397 49.47 µM -0.709459209970498 0.257633172125745 no 2515 0.23901977778732 3695 2598354 SGTC_1179 1021-1431 9.29 µM -0.710097997066497 0.257445058898976 no 2516 0.238821684148722 3693 2840958 SGTC_563 tetrahydrosecaminediol 614 µM -0.710432625249874 0.257346544403292 no 2517 0.238717948785329 3730 334274 A psychoactive constituent of the cannabis plant. SGTC_2329 6138490 200 µM -0.710646218506938 0.257283672819772 no 2518 0.238651747368209 3721 720019 SGTC_1473 k844-0725 134 µM -0.712369075017869 0.256776838779586 no 2519 0.238118130132724 3766 54682906 SGTC_13 0199-0087 65 µM -0.712487348034832 0.256742064014942 no 2520 0.238081521644094 3726 4589825 SGTC_3032 9089427 49.47 µM -0.712954192448492 0.256604825840012 no 2521 0.23793705161788 3672 17173707 SGTC_2704 st078022 71.1 µM -0.71324080477581 0.25652058939327 no 2522 0.237848380167475 3709 54697681 SGTC_519 k048-0011 62.8 µM -0.714726902541017 0.256084050729431 no 2523 0.237388905429074 3723 6836379 SGTC_663 1486-0733 13.9 µM -0.714976110869461 0.256010884166012 no 2524 0.237311902432759 3706 722445 YPR165W RHO1 SGTC_1665 st014639 11.4 µM -0.714990655568368 0.256006614237727 no 2525 0.237307408683226 3762 981133 YIL048W NEO1 SGTC_2698 st077697 67.5 µM -0.716530835550967 0.255554669614065 no 2526 0.236831817200323 3665 3154499 SGTC_3214 9129694 49.47 µM -0.719405269083432 0.254712322700017 no 2527 0.235945625636212 3676 17158655 SGTC_2285 7945142 200 µM -0.719903253868232 0.25456653716547 no 2528 0.235792282235154 3736 2970608 SGTC_1559 coumarin 343 70.1 µM -0.720051781199277 0.254523064107625 no 2529 0.235746557168947 3711 108770 A hepatotoxic, DNA x-linker. SGTC_1114 scopoletin 1.73284 µM -0.720413383176786 0.254417241644167 no 2530 0.235635256187616 3706 5280460 A coumarin with genotoxic properties. SGTC_1651 st011928 86.1 µM -0.721991116319025 0.253955789509033 no 2531 0.23514996968177 3707 720198 SGTC_1539 benzyladenosine 56 µM -0.722818422019785 0.253713996493114 no 2532 0.234895723909926 3695 92208 A nucleotide analog. SGTC_1983 st071813 46.9 µM -0.72383258856097 0.253417755488975 no 2533 0.23458425984645 3765 11838595 SGTC_160 3453-0671 289.699 µM -0.724695374815785 0.253165876293212 no 2534 0.234319466610975 3725 5322268 SGTC_1384 3089-0840 101 µM -0.725556080512422 0.252914735742522 no 2535 0.234055476822616 3682 1069836 SGTC_1489 4065-0444 182 µM -0.725848121384127 0.252829552555302 no 2536 0.233965941477975 3684 2877968 SGTC_2716 st080858 38.6235 µM -0.726855408354314 0.252535860583434 no 2537 0.233657268056014 3691 5296050 SGTC_1017 4239-0030 168 µM -0.727669665626037 0.252298581209862 no 2538 0.233407911847713 3761 1149593 SGTC_3142 9086498 49.47 µM -0.729349090853574 0.251809558262633 no 2539 0.232894075234423 3690 25236367 SGTC_2944 9067346 25.62 µM -0.732218239165149 0.250975265296974 no 2540 0.232017686780134 3666 6473075 SGTC_2724 maprotiline 69.64 µM -0.733173613317214 0.250697785911832 no 2541 0.231726273392539 3691 4011 A tricyclic antidepressant. SGTC_1150 3909-7983 10.9 µM -0.734672827595015 0.25026268104516 no 2542 0.231269386339389 3731 23965914 SGTC_969 1313-0238 134 µM -0.73553456124985 0.250012768380522 no 2543 0.231006999744398 3750 5212874 SGTC_481 bay k-8644 50 µM -0.735624852550906 0.249986590531924 no 2544 0.230979516848715 3717 2303 A calcium channel antagonist. SGTC_1816 st051957 91.6 µM -0.740730080893666 0.24850881825829 no 2545 0.229428558287706 3734 674121 SGTC_2467 5474540 200 µM -0.741733287957265 0.248218975591326 no 2546 0.229124473535159 3723 5413519 SGTC_12 0849-0099 9.267 µM -0.742315130050075 0.248050954679039 no 2547 0.228948213462517 3669 6071388 SGTC_2658 polymyxin b sulfate 77.05 µM -0.742902007503556 0.24788154117298 no 2548 0.228770505108194 3751 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides.  YIL048W NEO1 SGTC_1400 3771-8998 51.5 µM -0.743085624475137 0.247828549276456 no 2549 0.228714921214775 3680 670767 SGTC_1237 0330-0133 46.1 µM -0.743131216616583 0.24781539231217 no 2550 0.228701120894926 3681 X1237 YHR072W ERG7 SGTC_2423 st077119 87.2 µM -0.74329216154804 0.247768949861713 no 2551 0.228652408090273 3690 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae). SGTC_3231 9132313 49.47 µM -0.744406808577011 0.247447433641607 no 2552 0.228315200585075 3743 4905967 SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM -0.745184107674407 0.247223356329236 no 2553 0.228080214445142 3746 689007 SGTC_1092 toremifene 6.32 µM -0.746159448866661 0.246942341636538 no 2554 0.227785550481932 3732 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_729 4092-0585 94.1 µM -0.747620226594638 0.246521783204482 no 2555 0.227344630471878 3738 2169061 SGTC_2807 7945238 51.95 µM -0.748300901420094 0.246325947819752 no 2556 0.227139340463983 3792 17148797 SGTC_932 2857-0803 154 µM -0.7501552687843 0.245792855392896 no 2557 0.22658059785643 3857 674898 SGTC_1527 coumarin 137 µM -0.75073766693644 0.245625555812686 no 2558 0.226405274707909 3823 323 A hepatotoxic, DNA x-linker. SGTC_3114 9122766 49.47 µM -0.751997487983225 0.245263869197741 no 2559 0.226026284721644 3762 17176985 SGTC_2707 st078556 66.6 µM -0.752852256193746 0.245018633808632 no 2560 0.225769350477475 3742 17250899 SGTC_38 0929-0051 58.268 µM -0.753452545005933 0.244846488151821 no 2561 0.225589008831683 3778 1379719 SGTC_1049 3226-0134 66 µM -0.754028349916265 0.244681424964059 no 2562 0.22541609938364 3803 5702385 SGTC_2473 5854593 8.94 µM -0.754858909699377 0.244443438024599 no 2563 0.225166821376029 3682 2872951 SGTC_314 1671-0008 2.74 µM -0.755481941952523 0.244264997510458 no 2564 0.224979931683745 3696 3913060 SGTC_2911 7942208 15.64 µM -0.756246463297078 0.244046129579036 no 2565 0.224750719978267 3760 1243384 SGTC_1436 4092-1007 8.32 µM -0.756770680519533 0.243896117305085 no 2566 0.224593630589693 3753 2881121 SGTC_2027 5150920 200 µM -0.757081937596384 0.243807070178398 no 2567 0.224500387315362 3733 786715 SGTC_1583 clindamycin 39.6 µM -0.758160708436111 0.243498581898349 no 2568 0.224177390012728 3742 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis. SGTC_1100 amiodarone 5.07 µM -0.758296443692753 0.243459781610203 no 2569 0.224136767901661 3838 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. SGTC_2063 5246145 200 µM -0.758723594926917 0.243337701078904 no 2570 0.224008959680557 3807 711240 SGTC_2549 cedrol 20.94 µM -0.758923182620875 0.243280669927261 no 2571 0.223949255102199 3707 6708665 A sedative which affects the nervous system. SGTC_1286 0929-0070 131 µM -0.760922475062828 0.242709781306724 no 2572 0.223351686757647 3850 1420408 SGTC_345 1362-0200 395 µM -0.761496053790069 0.242546132554079 no 2573 0.223180417505674 3773 1419823 SGTC_1255 0566-0045 221 µM -0.761501820174642 0.242544487640244 no 2574 0.223178696056559 3832 2788469 SGTC_2529 gangaleoidin 93.61 µM -0.761729658930415 0.242479499391037 no 2575 0.223110684994739 3815 4565183 SGTC_2505 galangin 7.89 µM -0.761856396974977 0.242443352979936 no 2576 0.223072858133206 3691 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_836 0330-0104 1.35 µM -0.762683096608716 0.242207645178402 no 2577 0.22282620690662 3783 46494820 SGTC_3316 9136639 10.545 µM -0.762988066929532 0.242120723710255 no 2578 0.222735256273526 3808 4903665 SGTC_1671 st016596 74.5 µM -0.764897047726982 0.241577017823741 no 2579 0.222166426027152 3829 2829167 SGTC_1138 3761-0006 1.03 µM -0.766533863245192 0.241111357052388 no 2580 0.221679355361188 3748 12061087 SGTC_594 1487-1584 10.8 µM -0.766588016556257 0.241095959217624 no 2581 0.22166325127972 3765 5013332 SGTC_3297 9117502 71.43 µM -0.767344270748592 0.240880983419884 no 2582 0.221438426694445 3780 7453720 SGTC_2483 5729050 27.16 µM -0.767381706734126 0.240870344428459 no 2583 0.221427300847997 3787 2865180 SGTC_544 k015-0020 52.4 µM -0.767411518873544 0.24086187225266 no 2584 0.221418441011063 3793 3008304 SGTC_2406 ethylparaben 405.7 µM -0.767952862719586 0.240708058419442 no 2585 0.221257594889599 3827 8434 A possible steroid mimic. SGTC_2094 5332512 191.667 µM -0.770180087152193 0.24007579250571 no 2586 0.220596537141291 3835 755774 SGTC_3255 9139072 49.47 µM -0.770215375886693 0.240065782008518 no 2587 0.220586072281364 3790 17646060 SGTC_3132 9126706 49.47 µM -0.771777968448485 0.239622743309673 no 2588 0.220122971310148 3796 850858 SGTC_694 1315-0438 43.2 µM -0.772774388253843 0.239340463614881 no 2589 0.219827956705504 3752 6793154 SGTC_142 0335-0849 62.6745 µM -0.773408827655713 0.239160825464976 no 2590 0.219640233621381 3797 3889043 YPR107C YTH1 SGTC_2695 st077686 51.995 µM -0.774108741004381 0.238962734226229 no 2591 0.219433244410574 3846 2876092 SGTC_1466 k213-0079 57.5 µM -0.775031497527248 0.238701710514046 no 2592 0.219160523919467 3745 3657981 SGTC_1113 artemisinin 1.17947 µM -0.77545764965963 0.238581215890757 no 2593 0.21903464055617 3796 2240 An anti-malaria and mitochondrial poison. SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM -0.776341270080785 0.238331478107748 no 2594 0.218773755724877 3738 5711223 A potent inhibitor of glutathione S-transferases. SGTC_883 0850-0245 24.6 µM -0.776489403577803 0.238289625131162 no 2595 0.218730037504701 3880 6823229 YPR165W RHO1 SGTC_1369 1866-0067 208 µM -0.779469597611671 0.237448470218128 no 2596 0.217851569963948 3794 3531355 SGTC_1846 st056244 14.8 µM -0.77951051743109 0.237436932021163 no 2597 0.21783952226576 3829 5393182 SGTC_1358 1509-0022 2.48 µM -0.780193596971178 0.237244368952875 no 2598 0.217638465325394 3832 3258434 SGTC_1235 benzylparaben 21.5 µM -0.78084812739129 0.237059934509555 no 2599 0.217445912003093 3807 7180 SGTC_722 3534-0461 190 µM -0.781251175723458 0.236946402229361 no 2600 0.217327389994394 3834 658262 SGTC_2569 tetrandrine 100 µM -0.784686646529085 0.235979899104782 no 2601 0.216318656986035 3828 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_165 k038-0023 64.381 µM -0.785225582010222 0.235828477441634 no 2602 0.216160659475913 3806 46368543 SGTC_2516 gossypol 71.55 µM -0.78542999256705 0.235771059374666 no 2603 0.216100750753889 3847 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_1452 4194-0072 190 µM -0.786616026879334 0.235438059479132 no 2604 0.215753337199841 3809 1343545 SGTC_1945 st075991 56.6 µM -0.787575922629127 0.235168742096025 no 2605 0.21547240142047 3818 1084980 SGTC_2277 7947813 106.88 µM -0.788015735996428 0.235045400778026 no 2606 0.215343750743464 3909 1246798 SGTC_1947 st076332 61.6 µM -0.788663802641323 0.234863722026925 no 2607 0.215154264732249 3759 24208416 SGTC_447 ml7 120 µM -0.788731631190242 0.234844711485687 no 2608 0.215134438169251 3835 4216 Selective myosin light chain kinase inhibitor. SGTC_3245 9134821 49.47 µM -0.78878616194106 0.234829428580923 no 2609 0.215118499376299 3824 17014901 SGTC_2140 5586273 200 µM -0.7896912989079 0.234575833268647 no 2610 0.214854037040362 3773 854421 SGTC_45 0kpi-0036 14.9 µM -0.790706536787816 0.234291570931068 no 2611 0.214557630335473 3808 2795021 SGTC_360 0957-0399 1.01 µM -0.791297931986668 0.234126070686563 no 2612 0.214385077465338 3841 6752301 YPR165W RHO1 SGTC_440 fluspirilene 35.1 µM -0.792851517514507 0.233691612812654 no 2613 0.213932168553892 3943 3396 An atypical antipsychotic. SGTC_1649 st011737 51.3 µM -0.793238104275091 0.233583573887481 no 2614 0.213819555487801 3822 1761035 SGTC_221 trifluoperazine 10.304 µM -0.794046552622107 0.233357727376971 no 2615 0.21358416537941 3811 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1 SGTC_418 lividomycin a 100 µM -0.794052435626616 0.233356084356783 no 2616 0.213582453020723 3808 72394 An antibiotic. SGTC_1796 st049173 110.4 µM -0.794229103508094 0.233306747100438 no 2617 0.213531034250794 3767 94134 SGTC_983 1491-0821 12.2 µM -0.7943491828253 0.233273216386193 no 2618 0.213496089567069 3828 46495113 SGTC_1343 1487-0095 224 µM -0.794361049506488 0.233269902902504 no 2619 0.21349263638545 3793 4560101 YGL055W OLE1 SGTC_1506 4226-2149 212 µM -0.794992555862463 0.233093607714205 no 2620 0.213308916202193 3858 991114 SGTC_3106 9121286 49.47 µM -0.795505075621983 0.232950583953137 no 2621 0.213159879829419 3843 15943471 SGTC_1943 st076331 65.2 µM -0.795538589367264 0.232941233305769 no 2622 0.213150136434265 3858 24208415 SGTC_2951 9072950 58.06 µM -0.798682494482917 0.232064982154916 no 2623 0.212237269903641 3830 16488155 SGTC_808 0711-0032 135 µM -0.798843475128212 0.232020163994232 no 2624 0.212190589033133 3779 4252555 SGTC_1836 st055642 81 µM -0.79928792394859 0.231896451293225 no 2625 0.21206173974964 3849 8571 SGTC_2021 4019055 173 µM -0.799665075329486 0.231791499711951 no 2626 0.211952436429009 3793 44827708 YER133W GLC7 SGTC_2982 9019404 25.97 µM -0.802131582790221 0.231105786565121 no 2627 0.211238423725182 3785 22333232 SGTC_1842 st055362 61.2 µM -0.802913786837928 0.230888562874353 no 2628 0.211012283388579 3823 676032 SGTC_1680 diphenhydramine 100 µM -0.803817770115544 0.230637662290723 no 2629 0.210751112737369 3864 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1 SGTC_3167 9103034 49.47 µM -0.804448127442306 0.230462796785802 no 2630 0.210569107874602 3866 5127859 SGTC_2914 7968218 45.32 µM -0.80450741415814 0.230446354052426 no 2631 0.210551994599407 3831 2977111 SGTC_532 1548-0774 215 µM -0.805702295182538 0.23011510244524 no 2632 0.210207262900346 3979 5932993 SGTC_2164 5685496 200 µM -0.805710524958924 0.230112821864665 no 2633 0.210204889701188 3781 759046 SGTC_839 0122-0028 230 µM -0.806396287571258 0.229922832350991 no 2634 0.210007193417012 3839 759448 SGTC_3334 9142812 21.919 µM -0.808410451085234 0.229365319323327 no 2635 0.209427168788145 3902 45283678 SGTC_2273 7815444 169.05 µM -0.808499612867714 0.229340657198221 no 2636 0.209401514411216 3762 2824616 SGTC_374 0880-0231 82.3 µM -0.811418364169353 0.228534152657022 no 2637 0.208562728308754 3791 6833587 SGTC_3201 9113999 49.47 µM -0.811610412434874 0.228481142117674 no 2638 0.208507607329719 3894 16649224 SGTC_3343 9148379 18.9835 µM -0.81200882902001 0.228371190349198 no 2639 0.208393282681949 3905 1955036 SGTC_1218 1348-1416 30.7 µM -0.812717825569605 0.228175600805227 no 2640 0.208189929347085 3801 6787668 SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM -0.813165196496832 0.228052233908637 no 2641 0.20806167535908 3886 115019 SGTC_156 3474-0145 5.642 µM -0.814037540581849 0.227811784443386 no 2642 0.207811722633671 3735 2265471 SGTC_1224 0823-0416 294 µM -0.819490817224131 0.226311902635291 no 2643 0.206253219487222 3942 3598164 SGTC_117 lucigenin 22.078 µM -0.822303858928961 0.225540383284893 no 2644 0.205451990507476 3901 65100 An acridine derivative; a dye stuff and potential carcinogen. SGTC_88 0180-0332 8.668 µM -0.825789174431 0.224586550677213 no 2645 0.204461848055114 3932 3101745 SGTC_2731 amoxapine 43.43 µM -0.825927457591641 0.22454875373277 no 2646 0.204422621891665 3932 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine. SGTC_3355 9151058 44.0485 µM -0.828636671292887 0.223808972560351 no 2647 0.203655015348846 3864 17015728 SGTC_2310 7668677 200 µM -0.829552084302926 0.223559322251106 no 2648 0.203396038660112 3856 2197143 SGTC_1131 3454-3128 32.3 µM -0.829645960814059 0.223533729321694 no 2649 0.203369491456818 3947 710982 SGTC_313 3474-0040 5.03 µM -0.829937432464117 0.223454277963024 no 2650 0.20328707978448 3860 1043375 YIL048W NEO1 SGTC_775 4577-0580 57.3 µM -0.833076315445317 0.22259967826727 no 2651 0.202400845117636 3965 2006902 SGTC_3060 1327-0027 12.5 µM -0.83307834384908 0.222599126612397 no 2652 0.202400273164541 3808 16000455 YPR107C YTH1 SGTC_2288 7946289 167.31 µM -0.833952405372259 0.222361484992042 no 2653 0.202153902225363 3911 1246052 SGTC_338 4055-0136 114 µM -0.834553407033676 0.222198167441504 no 2654 0.201984602578137 3830 2900563 SGTC_110 0850-0284 111.64 µM -0.835728653917368 0.221879001083493 no 2655 0.201653785794861 3685 3906265 SGTC_1173 0443-0020 122 µM -0.835895637593985 0.221833673931571 no 2656 0.201606808398488 3879 5331295 SGTC_696 1560-0013 611 µM -0.836221390130944 0.221745264736325 no 2657 0.201515183546006 3918 1650269 SGTC_2176 5809774 33.9695 µM -0.836444864947293 0.221684625344156 no 2658 0.201452340917237 3876 2870539 SGTC_201 4262-0159 12.803 µM -0.837638132171393 0.221360995364582 no 2659 0.201116984933961 3912 1341029 SGTC_795 0685-0265 78 µM -0.840448696493398 0.220599801381252 no 2660 0.20032842768213 3928 302754 SGTC_789 1309-1135 70.6 µM -0.841214891675734 0.220392550752516 no 2661 0.200113779709169 3887 3092424 SGTC_2137 5261020 140 µM -0.841705823785834 0.220259815614543 no 2662 0.199976318804548 3859 763655 SGTC_1306 1185-0270 9.02 µM -0.841949782105056 0.220193872749851 no 2663 0.199908031639478 3920 1548076 SGTC_1543 azetidyl-2-carboxylic acid 198 µM -0.842356974229009 0.220083832388047 no 2664 0.199794084411164 3883 16486 A toxic proline analog. SGTC_2852 9023854 51.95 µM -0.842489804188095 0.220047942995936 no 2665 0.199756922189806 3978 19798528 SGTC_161 4065-0411 162.148 µM -0.843051435786273 0.21989623259271 no 2666 0.199599838861244 3938 1906281 YLR208W SEC13 SGTC_2190 6049624 200 µM -0.843939563129493 0.219656450274457 no 2667 0.199351589366972 3776 2265554 SGTC_2835 9006588 71.43 µM -0.844967631594494 0.219379073336723 no 2668 0.199064455782353 3987 2345538 SGTC_270 tamoxifen 5.46 µM -0.848052809946626 0.218547889323759 no 2669 0.198204280379885 3928 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  YIL048W NEO1 SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM -0.84870971925092 0.218371144517357 no 2670 0.198021418330433 3931 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair. SGTC_950 1165-0508 94.1 µM -0.848828175302087 0.218339282075596 no 2671 0.197988454888761 3926 6148369 SGTC_822 1487-0950 154 µM -0.849105714329708 0.218264639805208 no 2672 0.197911235498662 3898 1958375 SGTC_2607 solasodine 47.35 µM -0.850455912169919 0.217901722910882 no 2673 0.197535830988109 3924 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity. SGTC_2221 6807166 181.081 µM -0.850813002027245 0.217805799682582 no 2674 0.197436618943254 3830 674925 SGTC_710 3448-4187 58 µM -0.851449672252584 0.217634834645529 no 2675 0.197259804470291 3892 3946412 SGTC_3193 9111931 49.47 µM -0.851573397077956 0.217601619810589 no 2676 0.197225455038761 3929 17087244 SGTC_303 1348-1668 34.2 µM -0.852610772319391 0.217323243948898 no 2677 0.196937593386748 3906 5380509 SGTC_659 k018-0002 107 µM -0.853344584787777 0.217126452300927 no 2678 0.196734121162795 3893 6797879 YHR007C ERG11 SGTC_3293 9120939 62.045 µM -0.85391894999005 0.216972492602519 no 2679 0.196574949493511 3886 934087 SGTC_153 4077-0274 519.67 µM -0.854449888802817 0.216830229568697 no 2680 0.196427881835884 3914 3121976 SGTC_2001 4023502 57.655 µM -0.854940880678781 0.216698718173799 no 2681 0.19629193866388 3933 108941 YCR052W RSC6 SGTC_1203 3992-3522 103 µM -0.855648039950291 0.216509387775684 no 2682 0.196096244495976 4018 5322312 SGTC_2301 7769476 200 µM -0.859608329481075 0.215450855084899 no 2683 0.195002490973994 3959 977820 SGTC_2251 lansoprazole 556 µM -0.859686769045632 0.215429919597273 no 2684 0.194980865046057 3829 3883 Gastric proton pump inhibitor. YBR192W RIM2 SGTC_3131 9127911 49.47 µM -0.859746392110719 0.215414007015109 no 2685 0.1949644278361 3948 45595681 SGTC_2331 7980721 200 µM -0.861166672536849 0.215035155185026 no 2686 0.194573126346012 3895 2981221 SGTC_667 1498-1044 59 µM -0.862115498781197 0.214782276819769 no 2687 0.194311981696808 3930 6739982 SGTC_666 0272-0154 136 µM -0.862570640318879 0.214661035187694 no 2688 0.194186789250707 3934 6870312 SGTC_762 1165-0429 115 µM -0.862636770411106 0.214643422614193 no 2689 0.194168603419481 3886 5967793 SGTC_2669 eugenol 100 µM -0.863369868716638 0.214448231193768 no 2690 0.19396707026562 3898 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism. SGTC_1655 st012546 55.1 µM -0.864172999173896 0.214234511850061 no 2691 0.19374643122232 3895 720985 YLR208W SEC13 SGTC_1507 4075-3230 155 µM -0.864448734792245 0.214161165012838 no 2692 0.193670715386475 3806 659771 SGTC_80 0159-0065 512.242 µM -0.864566976947017 0.214129716577956 no 2693 0.193638252118599 3813 1548079 SGTC_889 0919-1524 82.7 µM -0.864951323571379 0.214027511873271 no 2694 0.193532753054234 3950 3905452 SGTC_2827 7993847 71.43 µM -0.865387074803338 0.213911672106964 no 2695 0.193413186386499 3990 2985692 SGTC_2895 9054447 58.44 µM -0.866501636364292 0.213615544077587 no 2696 0.193107564697065 3963 2697450 SGTC_2443 5493264 126.67 µM -0.87213280089581 0.212123055292921 no 2697 0.191567966924826 3959 5340055 SGTC_1229 0139-0193 12.2 µM -0.872670891946478 0.211980759006899 no 2698 0.191421243880414 3981 3090752 SGTC_2739 tacrine 100.86 µM -0.874678938853494 0.2114502312234 no 2699 0.190874311410882 3981 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders. SGTC_2488 5268135 45.7 µM -0.876270295029827 0.211030346310392 no 2700 0.19044155482507 4000 1270356 YLR208W SEC13 SGTC_1294 1000-1494 117 µM -0.876299261130268 0.211022708035026 no 2701 0.190433683313144 3930 712797 YDL207W GLE1 SGTC_3063 1327-0034 4 µM -0.876727034205981 0.210909924405835 no 2702 0.190317459625726 3848 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_845 0330-0138 4.51 µM -0.877518001838693 0.210701476585871 no 2703 0.190102672687357 3880 9039800 SGTC_1434 4073-0095 163 µM -0.879798818524578 0.210101078207176 no 2704 0.18948415241381 3894 24133745 SGTC_1056 3448-1962 115 µM -0.880314681673165 0.209965422751451 no 2705 0.189344430650945 3937 715507 SGTC_320 4092-0846 5.34 µM -0.881227051372614 0.209725624855034 no 2706 0.189097470231285 3927 1359356 SGTC_1455 4262-0120 131 µM -0.881284233371469 0.209710601089196 no 2707 0.189081998805007 4041 1529587 SGTC_949 1165-0505 146 µM -0.881775388262193 0.209581583114521 no 2708 0.188949141773544 3972 6244267 SGTC_2824 7998404 51.95 µM -0.884162009079536 0.208955323654104 no 2709 0.188304381671 3920 837851 SGTC_3042 9091578 49.47 µM -0.885492629235951 0.208606642390698 no 2710 0.187945496616784 3904 25236497 SGTC_175 3793-3120 23.7 µM -0.886025154808801 0.208467193327257 no 2711 0.187801986149195 3963 5322297 SGTC_3036 9090181 49.47 µM -0.886982431780139 0.208216655607071 no 2712 0.187544179537528 3972 25236586 SGTC_2520 obtusaquinone 4.71 µM -0.887665504511402 0.208037991055538 no 2713 0.187360353310639 3971 5967872 SGTC_237 nikkomycin 200 µM -0.887794564388422 0.208004244312413 no 2714 0.187325633667231 3954 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine. SGTC_640 3381-0960 37.1 µM -0.887838975725714 0.207992632326059 no 2715 0.187313687064599 3986 1745025 SGTC_1758 st042942 75.2445 µM -0.888894646617782 0.207716724588627 no 2716 0.187029851400862 3872 669317 SGTC_2974 9094440 9.66 µM -0.889348620269979 0.207598141581227 no 2717 0.186907874463724 4007 25236134 SGTC_610 4215-0184 155 µM -0.88953412655719 0.207549696774428 no 2718 0.186858045457791 3970 5605015 SGTC_1243 0416-0003 5.65 µM -0.889947283496637 0.207441825208786 no 2719 0.186747096559043 3957 2141977 SGTC_1793 st048256 72.231 µM -0.892068019289154 0.206888642012976 no 2720 0.186178237621681 3824 672022 SGTC_743 1275-0778 158 µM -0.892116376941617 0.206876038354037 no 2721 0.186165278865619 3957 2849257 YMR203W TOM40 SGTC_306 1672-3436 11.6 µM -0.893542517971924 0.206504541576259 no 2722 0.185783356737857 3992 6797378 SGTC_1586 deoxycorticosterone acetate 53.7 µM -0.894058142917442 0.206370323296202 no 2723 0.185645391521136 3956 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE. SGTC_1879 gemcitabine 100 µM -0.894145687967696 0.206347540266302 no 2724 0.185621973499764 3931 60750 A nucleoside analog which inhibits DNA replication. SGTC_2243 6634756 200 µM -0.895226657569177 0.206066347807455 no 2725 0.185332968646951 4045 885676 SGTC_69 0096-0274 206.684 µM -0.89565542320239 0.205954876037453 no 2726 0.185218412554092 4116 6741392 SGTC_3268 9137683 49.47 µM -0.897687108272577 0.20542715896476 no 2727 0.184676192151716 3995 1953228 SGTC_797 k781-0471 270 µM -0.898730955760569 0.205156338883698 no 2728 0.184397992118497 3942 23738129 SGTC_3059 1327-0034 3 µM -0.90177875195813 0.204366821120456 no 2729 0.183587204581888 3874 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_1909 st060837 51.5 µM -0.902951367136249 0.204063542958184 no 2730 0.183275853288873 3983 678937 SGTC_924 2046-0044 21.3 µM -0.90417849355903 0.203746453606624 no 2731 0.182950381060843 3972 3623589 SGTC_2847 9005661 71.43 µM -0.905442135282082 0.203420235876698 no 2732 0.182615601030682 3958 2991449 SGTC_737 1950-0117 57.9 µM -0.905882338133252 0.203306667732063 no 2733 0.182499066798548 3919 5393513 SGTC_2177 5811945 192 µM -0.906898956838832 0.203044534418592 no 2734 0.182230116429428 4018 5343475 SGTC_482 fipronil 114 µM -0.90871717431398 0.202576213844975 no 2735 0.181749718110212 4045 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels. SGTC_3113 9123498 49.47 µM -0.909900739909281 0.202271708602752 no 2736 0.181437429772863 4043 8897275 SGTC_905 2-aminofluorene 215 µM -0.912905046792076 0.201499997440133 no 2737 0.180646241505072 3977 1539 An established DNA mutagen. YPR165W RHO1 SGTC_3153 9100258 49.47 µM -0.913608929814681 0.201319447631963 no 2738 0.180461186245419 3916 25236848 SGTC_3092 9117248 49.47 µM -0.913986631693222 0.201222605048 no 2739 0.180361935098327 4071 17141857 SGTC_1944 st076371 56.9 µM -0.91454576671607 0.201079294382263 no 2740 0.18021507049292 3971 24208455 SGTC_770 0389-1121 67.2 µM -0.914896747126432 0.200989366649086 no 2741 0.180122918953645 4119 6753108 SGTC_2097 5376186 200 µM -0.915599436681771 0.200809396988608 no 2742 0.179938513456241 3955 742755 SGTC_865 0488-0499 301 µM -0.917647137945149 0.200285500859709 no 2743 0.179401815526665 3995 9634651 SGTC_1156 4092-0367 4.88 µM -0.917816900334121 0.200242104731263 no 2744 0.179357366405762 3999 1357585 SGTC_1299 1079-1439 3.74 µM -0.917837789036645 0.200236765371086 no 2745 0.179351897566391 3936 323161 SGTC_1500 4488-1866 171 µM -0.920783862458733 0.199484576892237 no 2746 0.178581640945684 4058 2900003 SGTC_1305 1181-0477 144 µM -0.920835142908005 0.199471499098232 no 2747 0.178568252046154 4041 6252086 SGTC_3314 9135860 59.4275 µM -0.921493314199116 0.199303694821415 no 2748 0.17839646511881 3993 25252478 SGTC_928 2764-0428 58.7 µM -0.92201451604898 0.199170871964369 no 2749 0.178260501992411 4029 662578 SGTC_1016 4226-1401 38 µM -0.922186649006831 0.199127017390084 no 2750 0.178215612941347 3966 2901613 SGTC_1866 st057638 64 µM -0.922592949064555 0.199023526781687 no 2751 0.178109685754647 3968 688802 SGTC_1664 st014217 9.02 µM -0.923123760573414 0.198888370112909 no 2752 0.177971356786176 4034 3982782 SGTC_1883 5-benzylidenerhodanine 20 µM -0.923198703020346 0.198869292521147 no 2753 0.177951832315573 3999 1273210 SGTC_222 nsc-310342 10.666 µM -0.923330731476352 0.198835685613697 no 2754 0.177917438730286 3950 432556 SGTC_1467 k284-1082 293 µM -0.923636584233037 0.198757846115492 no 2755 0.177837779793409 3960 3334705 SGTC_780 0109-0199 192 µM -0.924223708103838 0.198608474639185 no 2756 0.177684927228575 4103 610414 SGTC_812 4251-0442 148 µM -0.924758697393825 0.198472425806822 no 2757 0.177545719648488 4015 5723007 SGTC_588 3970-1144 52.9 µM -0.924806012538517 0.198460396178932 no 2758 0.177533411264038 3897 1888707 SGTC_3018 9082602 49.47 µM -0.924875914244372 0.198442624841112 no 2759 0.177515228281775 3967 17332089 SGTC_3095 9117207 49.47 µM -0.925659932757007 0.198243367050477 no 2760 0.177311368231347 3979 17015229 SGTC_2353 9059630 146.67 µM -0.926061865779606 0.198141262879897 no 2761 0.177206915177214 4049 4779114 SGTC_3288 9119690 36.221 µM -0.926463636224999 0.198039231746658 no 2762 0.177102543221279 4009 17595618 YKL019W RAM2 SGTC_3068 9116768 49.47 µM -0.92728207080546 0.197831485342413 no 2763 0.176890050382686 3973 41904888 SGTC_1383 3049-0032 20.7 µM -0.9273531345741 0.197813453166765 no 2764 0.176871607470701 4069 712864 SGTC_3072 9116419 49.47 µM -0.928112398202214 0.197620854744791 no 2765 0.17667463450808 4040 17170162 SGTC_193 1273-0060 1.558 µM -0.928242662829015 0.197587822595426 no 2766 0.176640854380949 3814 2847393 YHR072W ERG7 SGTC_1032 k061-1018 98.7 µM -0.928704756821136 0.197470672981339 no 2767 0.176521057450006 4118 4005393 SGTC_1441 4106-0040 13 µM -0.930403811357574 0.197040291578897 no 2768 0.176081022970125 3992 2904180 SGTC_1035 k081-0041 55.2 µM -0.930776066919788 0.196946072732524 no 2769 0.175984706121601 4027 731709 SGTC_2801 7907800 81.82 µM -0.932424612821136 0.196529149429777 no 2770 0.175558564915253 4034 6620925 SGTC_122 0236-0016 402.397 µM -0.932445802785823 0.196523793893575 no 2771 0.175553091671414 4009 6808838 SGTC_3311 9131146 2.8755 µM -0.934548819708505 0.195992718921915 no 2772 0.175010432714495 3993 4900406 YPR165W RHO1 SGTC_1450 4112-4260 37.6 µM -0.935333643066295 0.195794750728699 no 2773 0.174808191203742 3995 1633175 SGTC_382 3229-0966 23.2 µM -0.937895728567512 0.195149321332625 no 2774 0.174148999262728 4038 5722370 SGTC_2816 7982706 58.44 µM -0.940679054047478 0.194449625501093 no 2775 0.173434678053062 4076 2981853 SGTC_1795 st049545 62.3 µM -0.941348474961083 0.194281568913423 no 2776 0.173263154422822 3936 5291882 SGTC_1851 st056236 18.9 µM -0.944086233806038 0.193595181847058 no 2777 0.172562791717155 4014 5393171 SGTC_859 0439-0102 54.6 µM -0.948958991789959 0.192377190665525 no 2778 0.171320734645994 4033 610143 SGTC_1600 coumarin 106 71.1 µM -0.949452683571635 0.192254049782408 no 2779 0.17119521315293 4095 100336 A hepatotoxic, DNA x-linker. SGTC_3285 9112818 20.8695 µM -0.950234512280978 0.192059137948512 no 2780 0.170996552976511 4013 17017947 YPR165W RHO1 SGTC_3071 9117417 49.47 µM -0.950981850024227 0.1918729378775 no 2781 0.170806794758819 3966 45595590 YGL055W OLE1 SGTC_1432 4049-0298 68.4 µM -0.951285096898837 0.191797415093532 no 2782 0.170729835108266 4045 741646 SGTC_343 4130-2827 29.8 µM -0.952054015570282 0.191605999653792 no 2783 0.170534794224407 4063 1118244 SGTC_1214 0358-0031 63.7 µM -0.953979529999344 0.191127173676637 no 2784 0.170047002063714 4178 4301366 SGTC_249 wiskostatin 11.211 µM -0.954182349093649 0.191076780525019 no 2785 0.169995673845289 3992 2775510 A n-wasp and actin depolymerizer. SGTC_1219 1469-0211 33.1 µM -0.954414924143549 0.191019004132871 no 2786 0.169936827396358 4048 6822282 SGTC_450 aminopyrene 156 nM -0.955228764490035 0.190816913929328 no 2787 0.169731011245365 3934 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1 SGTC_3141 9094609 49.47 µM -0.955601254908192 0.190724462091444 no 2788 0.169636863636252 3992 25236309 YDL196W YDL196W SGTC_50 0929-0078 56.389 µM -0.955848361393791 0.190663145619978 no 2789 0.169574425523411 3909 1377751 SGTC_2965 9082772 38.63 µM -0.955915276963175 0.190646543416719 no 2790 0.169557520038725 4055 16459634 SGTC_611 3453-1652 23.7 µM -0.956369912945436 0.190533768665235 no 2791 0.169442689875541 4047 1560575 SGTC_1961 st076550 68.7 µM -0.95895781169438 0.189892607738709 no 2792 0.16878999944862 4073 1579337 SGTC_1606 st000094 49.2 µM -0.959108678897238 0.189855270828652 no 2793 0.168751999337554 4075 1242210 SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM -0.96191048456103 0.189162695039341 no 2794 0.168047285735948 4069 551469 SGTC_1499 4480-0877 67.3 µM -0.962136783270968 0.189106824452258 no 2795 0.167990449585065 3963 2861909 SGTC_446 go6976 132 µM -0.962249840273864 0.189078915766702 no 2796 0.167962059339388 4063 3501 A protein kinase C inhibitor. SGTC_1557 sumaresinolic acid 42.3 µM -0.965149041588028 0.188364100298392 no 2797 0.16723508316482 4021 9982268 A natural terpine and antifungal of unknown mechanisn. SGTC_127 0180-0333 59.125 µM -0.966593502422684 0.188008582809221 no 2798 0.166873642023639 3918 771601 SGTC_474 dl-dihydrosphingosine 5 µM -0.971446407039424 0.186817199650596 no 2799 0.165663014322538 4072 3058739 A sphingolipid protein kinase C inhibitor. SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM -0.971939713499042 0.186696355592819 no 2800 0.165540270631637 4071 2374 Ca(2+)-ATPase inhibitor. SGTC_1070 indatraline 8.81 µM -0.971954891409307 0.18669263826537 no 2801 0.165536495022289 4062 10314472 A monamine transport inhibitor. YGL099W LSG1 SGTC_1295 1013-0063 9.78 µM -0.97283562595589 0.186477009927788 no 2802 0.165317501649789 4067 6826038 SGTC_1367 1812-0510 76.9 µM -0.975014727839943 0.185944168421385 no 2803 0.164776477226458 4099 1142582 YDR527W RBA50 SGTC_2067 5224629 34.075 µM -0.975500360405552 0.185825548639239 no 2804 0.164656061501808 4075 2835000 SGTC_2373 9071805 200 µM -0.97606552195724 0.185687562348531 no 2805 0.164515997858485 4062 10149009 SGTC_1388 3346-4487 254 µM -0.97616131974653 0.185664179265066 no 2806 0.164492264006804 4121 3345614 SGTC_65 0798-0905 34.986 µM -0.978763468577794 0.185029725095238 no 2807 0.163848431928292 4177 3602145 SGTC_1540 guanosine 70.6 µM -0.978850951237004 0.185008418562135 no 2808 0.163826815139256 3938 6802 Guanosine is a purine nucleoside SGTC_1826 st055655 41.6 µM -0.979768917740515 0.184784938368211 no 2809 0.163600099080312 4092 676168 SGTC_2810 7959871 45.46 µM -0.9812018578583 0.184436422723714 no 2810 0.16324660409317 4037 2974535 SGTC_2557 derrustone 83.84 µM -0.981618506147726 0.184335163485236 no 2811 0.16314391345773 4076 629853 An antioxidant. SGTC_2442 5158906 48.48 µM -0.981895276339224 0.184267918349474 no 2812 0.163075721563954 4088 1893835 SGTC_1819 st053448 58.6 µM -0.982306907793446 0.184167935048626 no 2813 0.162974336213339 3978 2857616 SGTC_793 0488-0545 106 µM -0.983819151024997 0.183800908412884 no 2814 0.162602220666834 4090 292548 SGTC_2985 9022375 71.43 µM -0.984223864415163 0.183702760416984 no 2815 0.162502727253858 4141 4939335 SGTC_2818 7996756 12.99 µM -0.984494663135141 0.183637106620113 no 2816 0.162436177110377 4074 2241621 SGTC_1171 0368-0077 21.4 µM -0.986715142368792 0.183099314133425 no 2817 0.161891152325023 4027 3239779 SGTC_1616 st002734 56.1 µM -0.987049790673777 0.183018348735848 no 2818 0.161809115099848 4018 4026101 SGTC_1319 1306-0155 43.7 µM -0.98796843640546 0.182796204828109 no 2819 0.161584053330262 4123 3122360 SGTC_1167 k781-0610 148 µM -0.990611322007675 0.182158050058646 no 2820 0.1609377035205 4113 4525169 SGTC_2656 pseudo-anisatin 100 µM -0.991184669820378 0.182019792751635 no 2821 0.160797707418001 4104 6708809 A neurotoxin. SGTC_768 0384-0033 77.3 µM -0.993814874848775 0.181386385356835 no 2822 0.160156501504565 4046 3965305 YMR134W ERG29 SGTC_155 k072-0202 43.6 µM -0.994927754558533 0.181118797053714 no 2823 0.159885701494444 3980 5857737 SGTC_2496 diffractaic acid 79.83 µM -0.997074935411295 0.180603213677766 no 2824 0.159364069078878 4115 94870 An apoptosis inducer which activates caspases. SGTC_1115 galangin 695.678 nM -0.997984668573769 0.180385045447104 no 2825 0.159143396525875 4139 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_2893 9048488 25.97 µM -1.00022145515106 0.17984933251766 no 2826 0.158601674201517 4126 6467338 SGTC_2877 9040724 71.43 µM -1.00062191710069 0.179753527003495 no 2827 0.158504814994834 4083 6463895 SGTC_631 k072-0230 41.5 µM -1.00289176483042 0.179211100401826 no 2828 0.15795654321525 4122 5773147 SGTC_1993 st073995 70.8 µM -1.00395200269752 0.178958087967512 no 2829 0.15770087455927 4071 3098394 SGTC_252 miconazole 1.30953 nM -1.00418471881067 0.178902583292451 no 2830 0.157644793162873 3996 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_2558 carylophyllene oxide 100 µM -1.00599699264998 0.178470712112488 no 2831 0.157208508356949 4216 6708694 An oxygenated terpenoid and antifungal agent. SGTC_623 k072-0108 16.9 µM -1.00607895113121 0.178451196654427 no 2832 0.157188796544772 4059 5382803 SGTC_1259 0671-0132 43 µM -1.00766978053043 0.178072664291089 no 2833 0.156806508538403 4012 X1259 SGTC_2532 xanthone 78.9 µM -1.0083501688584 0.17791092290466 no 2834 0.15664319316816 4097 7020 An insecticide. SGTC_1497 4476-2978 41.3 µM -1.00966988730292 0.177597464694794 no 2835 0.156326737063235 4138 1528379 SGTC_1590 st077108 57.8 µM -1.01020969175307 0.177469351375964 no 2836 0.156197418450888 4122 5489485 SGTC_1013 4112-3890 241 µM -1.01050406940029 0.177399510483246 no 2837 0.156126925380598 4050 705171 SGTC_2218 6965428 192.983 µM -1.01219409296568 0.176998889402562 no 2838 0.155722630004674 3984 675684 SGTC_291 SEC14.278 35.5 µM -1.01315763760095 0.176770736656494 no 2839 0.155492435626 4150 1068044 SGTC_1117 retinoic acid 1.10837 µM -1.01366749135355 0.176650086274236 no 2840 0.155370720548971 4150 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR). SGTC_3055 9094636 49.47 µM -1.0149469078051 0.176347558039483 no 2841 0.155065568163315 4129 25236176 SGTC_2691 st077356 60.2 µM -1.01514698181751 0.176300278598888 no 2842 0.155017884508305 4154 2839272 SGTC_2216 7189485 200 µM -1.01599455349038 0.17610007811911 no 2843 0.154815990089595 4102 731273 SGTC_95 0471-0001 561.058 µM -1.0159980837912 0.176099244546264 no 2844 0.154815149523512 4103 4015405 SGTC_1735 st034310 56.75 µM -1.01722584874948 0.175809496803169 no 2845 0.154523001030052 4174 871153 SGTC_2617 dihydrotanshinone i 20.83 µM -1.02176337538208 0.174741280480503 no 2846 0.153446453770936 4094 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12 SGTC_2598 perillyl alcohol 100 µM -1.02411234140469 0.174189913172906 no 2847 0.15289110792454 4160 10819 An apoptosis inducer. SGTC_1720 st037298 9.481 µM -1.02527047921912 0.173918473600981 no 2848 0.15261779048874 4129 597396 SGTC_2374 9071832 200 µM -1.02722831507423 0.173460216145706 no 2849 0.152156484049503 4028 17381698 SGTC_2725 haloperidol 53.21 µM -1.02889786698721 0.173070043072045 no 2850 0.151763835408916 4051 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_2777 climbazole 1.536 µM -1.03033862596075 0.172733788493533 no 2851 0.151425536475186 3979 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2 SGTC_622 1348-1566 26.3 µM -1.03062559918737 0.172666862408167 no 2852 0.151358213356186 4148 7340407 SGTC_257 daunorubicin 18.5 µM -1.03254258766876 0.172220218589245 no 2853 0.150909003870234 4139 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_2936 9038235 15.59 µM -1.03367002431221 0.171957878991949 no 2854 0.150645225556848 4064 4749415 SGTC_784 4579-0127 173 µM -1.03954619097349 0.170594705860881 no 2855 0.149275393685584 4186 1948547 SGTC_1193 1488-0126 41.5 µM -1.04211624879798 0.170000675831903 no 2856 0.148678893022583 4098 1384710 SGTC_2252 omeprazole 400 µM -1.04418893957239 0.169522571715191 no 2857 0.148198991583128 4095 4594 A proton pump inhibitor. SGTC_2198 6589944 200 µM -1.04505564290508 0.169322906757948 no 2858 0.147998626654836 4141 5290268 SGTC_22 0964-0034 14.468 µM -1.046710069134 0.168942191068013 no 2859 0.1476166591491 4145 138402 SGTC_3207 9114163 49.47 µM -1.04902291123676 0.168410883522546 no 2860 0.147083786857321 4186 849233 SGTC_907 3448-6986 75.5 µM -1.051383659937 0.167869680218112 no 2861 0.146541208716328 4184 590582 SGTC_2396 5342950 42.78 µM -1.05324833899912 0.167442993584456 no 2862 0.146113594582014 4130 1886677 SGTC_958 1222-0007 33 µM -1.05352548269647 0.167379635663473 no 2863 0.146050110727761 4233 7312461 SGTC_1186 1319-0216 26 µM -1.05380319644759 0.167316162920904 no 2864 0.145986514884677 4213 4565136 SGTC_147 4466-0538 29.23 µM -1.05403941514387 0.167262186272828 no 2865 0.145932435964589 4248 6742687 YHR072W ERG7 SGTC_1169 aniline yellow 25.8 µM -1.05425869742287 0.167212089691219 no 2866 0.145882246446814 4071 6051 A DNA damaging agent. SGTC_972 1319-0219 195 µM -1.05519688051273 0.166997864383072 no 2867 0.145667645286251 4132 23903702 SGTC_1877 wortmannin 25 µM -1.05811002131623 0.166333804632216 no 2868 0.145002643090604 4150 312145 A covalent inhibitor of PI 3-kinase. SGTC_1650 st011916 45.8 µM -1.05817100443963 0.166319921581035 no 2869 0.144988743936886 4070 242528 SGTC_1848 st056003 16.4 µM -1.05992576410972 0.165920764117347 no 2870 0.144589186738986 4171 146492 SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM -1.06473734223416 0.16482944736896 no 2871 0.14349740329196 4284 16725076 SGTC_2270 7924575 90.91 µM -1.0649326413193 0.164785249879456 no 2872 0.14345320629518 4151 1262135 SGTC_1621 st003705 32.4 µM -1.06536779885995 0.164686798428647 no 2873 0.143354761385403 4162 24207032 SGTC_2688 kanamycin b 96.69 µM -1.06566156426957 0.164620357543015 no 2874 0.143288329162641 4217 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis. SGTC_1696 st025591 34.7925 µM -1.06662726490648 0.16440206756812 no 2875 0.143070091775486 4173 2787147 SGTC_57 miconazole 162.5 nM -1.06680673724554 0.16436151976907 no 2876 0.143029557821906 4045 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_2878 9043973 25.97 µM -1.06806565006382 0.164077278573116 no 2877 0.142745449594754 4213 6465167 SGTC_2138 5575593 77.673 µM -1.0712282651825 0.16336462123856 no 2878 0.142033402713694 4155 762213 SGTC_734 2023-0417 80 µM -1.07374083767352 0.162799878687009 no 2879 0.141469426343455 4161 3935732 SGTC_2163 5671233 125 µM -1.07895523275169 0.161631913084626 no 2880 0.140303842417846 4146 701023 SGTC_167 3672-0051 66.205 µM -1.07917359292768 0.161583122318812 no 2881 0.140255174631181 4079 3237971 SGTC_1526 st051518 75 µM -1.07946067850478 0.161518990044819 no 2882 0.14019120687946 4168 673993 SGTC_1551 6-bromo-3'-methylflavone 63.5 µM -1.08056650577967 0.161272113518412 no 2883 0.139944994179934 4180 688751 SGTC_787 4152-0075 138 µM -1.08153034023377 0.161057137835389 no 2884 0.139730636037569 4185 9566539 SGTC_2650 prasterone 100 µM -1.08440965913738 0.16041604274211 no 2885 0.139091601456913 4153 16759247 A steroid and weak partial agonist of the androgen receptor. SGTC_2989 9073649 71.4286 µM -1.08549170890302 0.160175550472493 no 2886 0.138851966935664 4124 21367202 SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM -1.08596230897007 0.160071030271915 no 2887 0.138747833978361 4203 4174840 SGTC_2402 5553605 200 µM -1.08703221906115 0.159833569392658 no 2888 0.138511285488052 4281 6758546 SGTC_1366 1683-0113 21.9 µM -1.08741176388843 0.159749386829636 no 2889 0.138427437260449 4190 708623 SGTC_1797 st048695 56.8 µM -1.08762737725641 0.159701576980153 no 2890 0.138379819829067 4145 592262 YIL048W NEO1 SGTC_2476 5806916 10.51 µM -1.0877958180429 0.159664233637028 no 2891 0.138342628059831 4047 2870194 SGTC_1750 st081859 2.357 µM -1.08890338994349 0.159418827136765 no 2892 0.138098245597342 4134 5291695 SGTC_132 0417-1715 25.805 µM -1.08963393716575 0.159257093838357 no 2893 0.137937213737426 4170 6769098 SGTC_582 0987-0078 156 µM -1.09058418236881 0.159046883218167 no 2894 0.137727946380842 4225 1625765 SGTC_2518 prenyletin 46.28 µM -1.09129588208974 0.158889562089047 no 2895 0.137571354571987 4154 3873459 A coumarin with calcium channel inhibitory activity. SGTC_2523 spermine 47.74 µM -1.09142291734602 0.158861491692816 no 2896 0.137543416413176 4206 1103 A DNA binding polyamine. SGTC_1207 2099-0101 141 µM -1.09187895368664 0.158760750218887 no 2897 0.137443154781451 4191 5837381 SGTC_2413 inermin 26.06 µM -1.09299985230801 0.158513314236489 no 2898 0.137196932297034 4273 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1 SGTC_2294 7971431 200 µM -1.10008256804627 0.156955671326863 no 2899 0.135648074134606 4187 5741572 SGTC_457 grayanotoxin iii 135 µM -1.10093034624914 0.15676990357355 no 2900 0.135463486692832 4035 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity. SGTC_3162 9099653 49.47 µM -1.10254225044119 0.156417097455902 no 2901 0.135113000419892 4168 25237511 SGTC_218 alverine citrate 93.75 µM -1.10303385253755 0.156309602000883 no 2902 0.135006232194441 4236 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_2335 9018011 154.17 µM -1.1035561585796 0.156195446039515 no 2903 0.134892858971044 4197 6458208 SGTC_401 neomycin 50 µM -1.10643938339615 0.155566272996591 no 2904 0.13426819354937 4168 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis. SGTC_488 nitrendipine 139 µM -1.10677218414383 0.155493757483149 no 2905 0.134196218664057 4233 4507 Dihydropyridine L-type calcium channel blocker. SGTC_2341 7987486 176.74 µM -1.10696605363596 0.155451524632704 no 2906 0.134154302687526 4232 1258686 SGTC_220 paclitaxel 373.376 µM -1.10762522836386 0.155307985539636 no 2907 0.134011851657327 4158 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_908 3448-7491 47.7 µM -1.10836473564438 0.155147057716705 no 2908 0.133852164096836 4203 1203031 SGTC_224 benfluorex 43.875 µM -1.11163586672402 0.154436531680054 no 2909 0.133147372370196 4238 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis. SGTC_3321 9137793 26.8275 µM -1.11178077473071 0.154405105888079 no 2910 0.133116209950365 4175 4904192 SGTC_67 0335-0847 266 µM -1.11273454985143 0.154198368857502 no 2911 0.132911226172575 4315 4552207 YOR254C SEC63 SGTC_552 k242-0005 476 µM -1.11311597031458 0.154115744734013 no 2912 0.132829312780457 4278 4088318 SGTC_2455 5377712 9.75 µM -1.11439308148465 0.153839307392685 no 2913 0.132555295048614 4200 2243908 SGTC_1914 st062367 72.6 µM -1.11700136369397 0.153275751343303 no 2914 0.131996871056568 4208 978205 SGTC_25 0118-0223 35.662 µM -1.11727289648898 0.153217161577892 no 2915 0.13193883022776 4215 5333628 SGTC_1006 4099-6547 255 µM -1.11926153558688 0.152788517020655 no 2916 0.131514290096833 4233 3146833 SGTC_2540 epiandrosterone 100 µM -1.11974899089859 0.15268356912967 no 2917 0.131410370855688 4258 441302 A steroid. SGTC_2175 5807670 165.306 µM -1.11986519463084 0.152658557821255 no 2918 0.13138560607606 4187 241186 SGTC_2597 laccaic acid a 100 µM -1.12054875107036 0.152511486406199 no 2919 0.13123999504906 4212 5491415 A textile dye. SGTC_24 0417-1663 219 µM -1.1228338865941 0.152020508026998 no 2920 0.130754025275648 4240 4329390 SGTC_426 0988-0037 14.6 µM -1.1236643104322 0.151842345646137 no 2921 0.130577731210683 4261 5383008 SGTC_2756 carbadox 75.1 µM -1.12523449680921 0.151505851013657 no 2922 0.1302448392929 4162 2553 A substituted quinoxaline antibiotic. YLR208W SEC13 SGTC_1931 st074438 57.1 µM -1.12552135584373 0.151444430049933 no 2923 0.130184086402765 4209 2787313 SGTC_2927 9011802 47.9 µM -1.12624632582296 0.151289276551788 no 2924 0.130030634910287 4231 43912568 SGTC_2178 5812956 200 µM -1.12731569675804 0.151060609592173 no 2925 0.129804514058363 4185 5403383 SGTC_70 0141-0289 43.283 µM -1.13172447547433 0.150120296231804 no 2926 0.128875144118336 4197 352408 SGTC_3234 9132280 49.47 µM -1.13671014072999 0.14906165418077 no 2927 0.127829739339623 4254 17612295 SGTC_2387 9077560 195.08 µM -1.13734783776649 0.148926607990839 no 2928 0.12769645199059 4224 5303272 SGTC_44 0929-0055 61.211 µM -1.13781527632888 0.148827669666636 no 2929 0.127598812357009 4119 1379590 SGTC_417 st075190 100 µM -1.13841219681165 0.148701388997287 no 2930 0.127474201723694 4232 222757 SGTC_2424 5537928 59.2 µM -1.14049258893915 0.148261834514737 no 2931 0.127040569258665 4249 5382802 SGTC_1128 3448-9350 235 µM -1.14171227477325 0.148004538474268 no 2932 0.126786818455111 4277 619386 SGTC_2250 alverine citrate 130 µM -1.14262972412991 0.147811197107566 no 2933 0.126596179459782 4114 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1 SGTC_2845 9003024 42.97 µM -1.14282629872222 0.147769793396159 no 2934 0.126555358740536 4284 2990173 SGTC_6 0844-0013 19.835 µM -1.14313935017596 0.147703872667836 no 2935 0.126490369341456 4372 1584900 SGTC_766 1391-0721 126 µM -1.14334546863408 0.147660480081336 no 2936 0.126447591899484 4259 1020919 YIL115C NUP159 SGTC_1482 3346-2049 8.48 µM -1.1436972333174 0.147586445399134 no 2937 0.126374610590498 4244 3826804 SGTC_869 0564-0080 44.1 µM -1.14559360537501 0.147187751012013 no 2938 0.125981672196329 4234 6843321 SGTC_186 3455-3465 67.277 µM -1.15171965169332 0.145904744680974 no 2939 0.124718147099698 4245 755278 SGTC_2546 rhodinyl acetate 100 µM -1.15349920673073 0.145533457129959 no 2940 0.124352771488932 4193 6708682 SGTC_1282 0886-0010 32.4 µM -1.15421461090908 0.145384373937163 no 2941 0.124206096928456 4271 2836211 YNL267W PIK1 SGTC_1653 st012112 65 µM -1.15488153517306 0.145245486035735 no 2942 0.124069470918493 4230 720429 SGTC_860 0443-0016 25.1 µM -1.15649999569667 0.144908810691285 no 2943 0.123738350664962 4271 5337942 SGTC_164 4100-3994 89.624 µM -1.15765021380673 0.144669859699028 no 2944 0.123503404371223 4240 4615967 SGTC_699 0375-0592 111 µM -1.16320973554733 0.143518645093096 no 2945 0.12237220875957 4328 762578 SGTC_834 0312-0008 75.7 µM -1.16331139333256 0.143497652467382 no 2946 0.122351592377161 4262 6385573 YIL048W NEO1 SGTC_1096 rimcazole 32.2 µM -1.16345143013916 0.143468737857737 no 2947 0.122323196652185 4171 18528119 A dopamine reuptake inhibitor. SGTC_1206 3978-0017 132 µM -1.16432694974772 0.143288050931094 no 2948 0.122145769519713 4329 3873677 SGTC_688 0527-0193 473 µM -1.16530383285965 0.143086626401531 no 2949 0.121948014095054 4300 4007154 SGTC_2431 5490079 200 µM -1.16749423993071 0.142635679747672 no 2950 0.121505416556821 4306 5722345 SGTC_1912 st060209 90.8 µM -1.16827332097585 0.142475519578019 no 2951 0.121348266630948 4253 688787 SGTC_906 1165-0455 526 µM -1.16876278385323 0.142374960118619 no 2952 0.121249609267454 4244 3252859 SGTC_301 4119-0100 24.5 µM -1.16955303070571 0.142212706375766 no 2953 0.121090444213592 4280 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1 SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM -1.17532366734017 0.141031670993804 no 2954 0.119932624643741 4239 2724278 An inhibitor of dopamine biosynthesis. SGTC_3222 9128301 49.47 µM -1.17544740507603 0.141006419527336 no 2955 0.119907883683488 4261 4911358 SGTC_194 1486-1323 56.904 µM -1.17903978230326 0.140274650898923 no 2956 0.119191167532841 4355 5178754 SGTC_27 0485-0001 32.618 µM -1.17950021464377 0.140181047463923 no 2957 0.11909952563892 4234 2054479 SGTC_1112 tnp00069 1.16933 µM -1.1861953632583 0.138824753163237 no 2958 0.117772578468762 4282 145826 SGTC_1413 3910-0535 34.4 µM -1.18701236255613 0.138659860406034 no 2959 0.117611372098054 4299 2876951 SGTC_32 0928-0142 34.1 µM -1.18942543340659 0.138173616068789 no 2960 0.117136148740883 4259 2244242 SGTC_3272 9137413 49.47 µM -1.18942954729382 0.138172788096469 no 2961 0.117135339726861 4175 17614870 SGTC_1364 1653-0028 37.6 µM -1.19144269639919 0.137768021973264 no 2962 0.116739919940346 4273 5718652 SGTC_455 paf C-16 10 µM -1.19173247530552 0.137709825367205 no 2963 0.116683080001851 4247 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis. SGTC_3120 9124077 49.47 µM -1.19222516055928 0.137610917378179 no 2964 0.116586485168046 4411 18774327 YGL155W CDC43 SGTC_1277 0873-0036 22 µM -1.19422224227726 0.13721049413633 no 2965 0.116195522377992 4350 5965735 SGTC_1039 k821-0043 94 µM -1.2008549826894 0.135886316807857 no 2966 0.114903729666734 4285 15992768 SGTC_189 3970-0742 2.116 µM -1.20159643835147 0.135738836309698 no 2967 0.114759961041518 4264 2891807 SGTC_1635 st007035 42.4 µM -1.20289126449198 0.135481549695042 no 2968 0.114509200599415 4262 3716403 SGTC_368 fentichlor 4.58 µM -1.20325494287431 0.135409345642725 no 2969 0.114438839613311 4304 7329 A pesticide. SGTC_2477 5967686 25.23 µM -1.20379555288293 0.135302062650113 no 2970 0.114334304491514 4269 776118 SGTC_1041 0206-0046 107 µM -1.20477642452701 0.135107559396083 no 2971 0.11414481174958 4283 50494 SGTC_848 0368-0089 85.6 µM -1.20552722219544 0.134958808577849 no 2972 0.113999917781834 4282 762535 SGTC_2158 5657123 3.6195 µM -1.20757879223788 0.134552916921862 no 2973 0.113604660412571 4266 2858827 SGTC_2493 resveratrol 26.09 µM -1.20780737295516 0.134507745442267 no 2974 0.113560682409736 4209 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase. SGTC_2242 6630449 61.2675 µM -1.20959870360925 0.134154108178915 no 2975 0.113216457925192 4343 691249 YDR170C SEC7 SGTC_101 0490-5701 117.494 µM -1.21002329963229 0.134070379866003 no 2976 0.113134976235936 4134 4661669 SGTC_1404 3909-7820 48.3 µM -1.21029191027936 0.134017429670654 no 2977 0.113083450383219 4271 23741373 SGTC_2884 9058502 51.95 µM -1.22061501715418 0.131993356749145 no 2978 0.111115908883876 4331 6471554 SGTC_2342 7990637 118.86 µM -1.2254170363805 0.131059036158288 no 2979 0.110209065624654 4329 2033102 YER133W GLC7 SGTC_2030 5175110 200 µM -1.22874641017432 0.130413933923614 no 2980 0.109583449828852 4316 2831986 SGTC_993 3909-8757 62.7 µM -1.22887439171858 0.130389180025501 no 2981 0.109559452079846 4245 4288324 YLR208W SEC13 SGTC_1695 st026914 34.495 µM -1.22963133994491 0.130242839284497 no 2982 0.109417594296106 4303 3289191 SGTC_2922 7999257 32.47 µM -1.23209086108642 0.129768124931225 no 2983 0.108957572429579 4279 2988377 SGTC_2950 9072895 21.46 µM -1.233088095694 0.129575989613322 no 2984 0.10877144917133 4284 17332245 SGTC_1075 aripiprazole 15.2 µM -1.23495317279902 0.129217177853292 no 2985 0.108423966167456 4374 60795 An atypical antipschotic. YIL048W NEO1 SGTC_2130 NSC 7 2.4545 µM -1.23509005911147 0.129190870217452 no 2986 0.108398494340492 4383 21448 SGTC_3319 9138450 16.7555 µM -1.23823035268852 0.128588369134886 no 2987 0.107815330006993 4250 2029690 SGTC_1578 josamycin 24.2 µM -1.24211768935447 0.127845244030277 no 2988 0.107096571415971 4320 5282165 A P450 substrate. SGTC_1033 k072-0102 21.3 µM -1.24303442408024 0.127670431631378 no 2989 0.106927574240259 4287 5965931 SGTC_1296 1068-0102 11.9 µM -1.24325479486321 0.127628433850072 no 2990 0.106886978273828 4307 767053 SGTC_1814 st052110 31.539 µM -1.24892130350986 0.126551820576776 no 2991 0.105846929445629 4254 674163 SGTC_668 1682-0499 62.6 µM -1.25564644403584 0.125282301173537 no 2992 0.104622092280604 4319 682214 SGTC_2420 aureobasidin a 50 nM -1.25571748241775 0.125268938731206 no 2993 0.104609209221614 4414 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1 SGTC_1023 4482-3888 16 µM -1.25970397465152 0.124520666910503 no 2994 0.103888085516056 4360 3303168 SGTC_3219 9131112 49.47 µM -1.2600517183102 0.124455543290418 no 2995 0.103825352933473 4215 17612988 YMR079W SEC14 SGTC_3108 9121785 49.47 µM -1.26397434006191 0.123722584322648 no 2996 0.10311961855849 4167 17140271 SGTC_1824 st053723 68.6 µM -1.26467075616438 0.123592772502154 no 2997 0.102994688623994 4349 675225 SGTC_2930 9013230 14.89 µM -1.26499884786982 0.123531649339051 no 2998 0.102935870438138 4329 2995857 SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM -1.26630391578414 0.123288726080306 no 2999 0.102702147787343 4384 6710655 SGTC_1247 0448-0043 5.84 µM -1.26786130103961 0.122999275172257 no 3000 0.102423743052566 4351 3089013 YGL099W LSG1 SGTC_3159 9100096 49.47 µM -1.26827060691333 0.122923281942732 no 3001 0.102350664964187 4283 25236875 SGTC_2912 7964298 10.93 µM -1.27439476400758 0.121790178325386 no 3002 0.101261773513497 4358 2975850 SGTC_2705 st078069 42.8 µM -1.2745121370106 0.12176853364923 no 3003 0.101240987037307 4377 1530061 SGTC_2348 9022543 33.42 µM -1.27501825901087 0.121675230988496 no 3004 0.101151389658431 4363 3162678 YDL140C RPO21 SGTC_3133 9127736 49.47 µM -1.27661143362515 0.12138186019012 no 3005 0.10086973162448 4353 27243420 SGTC_366 0181-0206 4.31 µM -1.28353899537448 0.120111987358199 no 3006 0.0996516534161019 4372 274874 SGTC_89 0302-0250 142.109 µM -1.28857526973447 0.119194697819194 no 3007 0.098772892770767 4448 4203518 YLR208W SEC13 SGTC_2954 9074818 52.69 µM -1.29015486585573 0.118908016985085 no 3008 0.0984984466746434 4380 16648742 SGTC_2677 mitomycin C 100 µM -1.29043060284289 0.118858023453555 no 3009 0.0984505961890992 4420 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_1952 st077036 64.1 µM -1.29086912449555 0.11877854621865 no 3010 0.0983745316539745 4373 2937007 SGTC_1430 4049-0248 69.1 µM -1.29135159396352 0.118691147305879 no 3011 0.0982908938069398 4380 22774488 SGTC_2664 lyso-paf C-16 73.48 µM -1.29291256277362 0.118408690531964 no 3012 0.0980206510052544 4319 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_1718 roemerine 11.9335 µM -1.29368762221202 0.118268620457153 no 3013 0.0978866712591392 4014 235224 An aporphine alkaloid with mutagenic activity. SGTC_692 k241-0027 77.8 µM -1.29374117109799 0.118258947338839 no 3014 0.0978774195529267 4395 3600480 SGTC_1276 0871-0068 94.2 µM -1.29518185020804 0.117998911735343 no 3015 0.0976287521904876 4387 3414906 SGTC_3223 9129970 49.47 µM -1.29541870695321 0.117956198984402 no 3016 0.0975879140863651 4372 17248386 SGTC_3353 9151644 39.2805 µM -1.29783229773545 0.11752157587006 no 3017 0.0971724842833416 4363 4909158 SGTC_2758 dehydroepiandrosterone 69.35 µM -1.29935427137053 0.117248092717121 no 3018 0.0969111886426017 4365 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem] SGTC_311 1315-0136 58 µM -1.30242725616832 0.116697283342584 no 3019 0.0963851850910765 4376 6759207 SGTC_2069 5228469 200 µM -1.30475235648396 0.116281747640863 no 3020 0.0959885935463944 4375 2835210 SGTC_349 k015-0014 24 µM -1.30566873771524 0.116118263219247 no 3021 0.0958326168405282 4378 2196908 SGTC_2757 clomiphene 4.22 µM -1.3059064140447 0.116075887896706 no 3022 0.0957921925578977 4391 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined. SGTC_2376 9072922 81.32 µM -1.30611191684092 0.116039257644122 no 3023 0.0957572505021781 4374 17087968 SGTC_619 1652-1634 108 µM -1.31075742135234 0.11521339896407 no 3024 0.0949698659775181 4356 5400454 SGTC_3229 9132204 49.47 µM -1.31238689962943 0.114924709280238 no 3025 0.0946948123885808 4455 17682924 SGTC_3002 9075603 71.4286 µM -1.31260711965037 0.114885733073597 no 3026 0.0946576846481801 4321 20105405 SGTC_1210 3013-0140 750 nM -1.31454278377351 0.114543549085705 no 3027 0.0943318051205755 4398 905973 SGTC_1856 st057054 55.7 µM -1.32048900432686 0.113496923352793 no 3028 0.093335902401777 4381 1266018 SGTC_1934 st074720 32.6 µM -1.32101747605788 0.113404235297809 no 3029 0.0932477685916238 4322 17250992 SGTC_2142 5622915 118.518 µM -1.323815742174 0.112914350285387 no 3030 0.0927821233187837 4382 5322196 SGTC_1780 st038448 24.544 µM -1.3242211496578 0.112843502144195 no 3031 0.0927148043707029 4408 728868 YDL195W SEC31 SGTC_397 arbidol 50 µM -1.32434130334879 0.112822510441244 no 3032 0.0926948594847884 4413 131410 A RNA synthesis inhibitor. SGTC_2983 9022671 12.99 µM -1.32586658095147 0.112556275914054 no 3033 0.0924419471266137 4379 6405161 SGTC_2627 acetyl isogambogic acid 100 µM -1.33091671935254 0.111677986493691 no 3034 0.0916082076134124 4392 6857789 A caspase activator and apoptosis inducer. SGTC_612 0302-0167 22.4 µM -1.33337895549833 0.111251551781715 no 3035 0.0912037374587555 4398 235821 SGTC_963 1269-2853 151 µM -1.33520661354451 0.110935774340224 no 3036 0.090904366452425 4374 3668223 SGTC_181 1447-1644 8.07 µM -1.33997374682188 0.110115145643129 no 3037 0.0901269401263379 4359 534600 SGTC_586 0957-0265 8.15 µM -1.34016415549558 0.11008245880367 no 3038 0.0900959910935596 4267 6752309 YPR165W | YPR107C RHO1 | YTH1 SGTC_1781 st038725 66.3 µM -1.34061831571961 0.110004522694649 no 3039 0.0900222037519817 4381 4270275 YIL048W NEO1 SGTC_732 3970-1727 52.7 µM -1.34312548267363 0.109574993116222 no 3040 0.0896156727179155 4480 1275699 SGTC_121 0557-0495 61.343 µM -1.34642569899575 0.109011435550444 no 3041 0.0890826338010394 4454 3104427 SGTC_2117 5521686 200 µM -1.34705625507024 0.108903996857555 no 3042 0.0889810577348231 4382 803312 SGTC_2327 6189656 200 µM -1.35153121684886 0.108143707230042 no 3043 0.0882626635314756 4472 5349088 SGTC_2563 tomatine 8.54 µM -1.3533508956576 0.107835641676323 no 3044 0.0879717783972065 4372 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties. SGTC_2133 5320837 200 µM -1.35336052843844 0.107834012562272 no 3045 0.0879702404514874 4419 2841355 SGTC_2596 sinensetin 100 µM -1.3570374460143 0.107213459512019 no 3046 0.0873846563252346 4415 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets. SGTC_1382 3002-2117 298 µM -1.35953774012825 0.106792958494846 no 3047 0.086988125911494 4479 1497314 SGTC_3087 9117406 49.47 µM -1.35957128261307 0.106787325400159 no 3048 0.0869828154429408 4426 42546093 SGTC_825 1988-2224 89.6 µM -1.35959479624843 0.106783376669253 no 3049 0.086979092892904 4387 1180859 SGTC_284 0988-0104 32.6 µM -1.36352041259386 0.106125609948467 no 3050 0.0863592778544 4378 4666532 SGTC_206 4546-0025 72.014 µM -1.36723797144621 0.105505408043824 no 3051 0.0857753635080601 4455 6620745 YIL048W NEO1 SGTC_1454 4239-0054 42.6 µM -1.36898328489922 0.105215142582035 no 3052 0.0855022499479714 4482 1340767 SGTC_86 0417-1630 471.922 µM -1.37740209262669 0.103823114027748 no 3053 0.0841939831316869 4398 3634867 SGTC_1176 0848-0131 83.3 µM -1.38060717531632 0.103296688160303 no 3054 0.0836998879709622 4485 6769040 SGTC_2361 9034121 116 µM -1.38146731985527 0.103155742220941 no 3055 0.0835676596676916 4439 6496917 SGTC_2084 5306078 60.6385 µM -1.38284127758311 0.102930891077871 no 3056 0.0833567695998507 4368 679340 SGTC_1496 4469-0713 57.4 µM -1.38310280965815 0.102888131159931 no 3057 0.0833166721568562 4395 746691 SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM -1.38437914843004 0.102679637760117 no 3058 0.0831211951219101 4442 23847180 SGTC_3020 9089140 49.47 µM -1.38760786034809 0.10215359020236 no 3059 0.0826282433125826 4437 17217859 SGTC_1617 st002906 78 µM -1.3884188404026 0.10202176746736 no 3060 0.0825047713110793 4410 5150859 SGTC_1927 st060202 13.8 µM -1.39085451734764 0.101626598636988 no 3061 0.0821347736625212 4356 688887 SGTC_2014 4013930 200 µM -1.39254311044162 0.101353293052138 no 3062 0.0818789982521373 4403 64556 SGTC_51 1013-0126 23.419 µM -1.39389456708567 0.101134940428088 no 3063 0.081674722571467 4426 1627850 SGTC_1936 st074407 74.3 µM -1.39925896530513 0.10027160456326 no 3064 0.0808676700444714 4460 809813 SGTC_3166 9102297 49.47 µM -1.40301056306048 0.0996710342800019 no 3065 0.0803068445395297 4440 25237072 SGTC_535 2293-4129 48.2 µM -1.40886810942288 0.0987385977228638 no 3066 0.0794370854716244 4443 396118 YIL048W NEO1 SGTC_2550 chrysin dimethyl ether 71.87 µM -1.41069407373981 0.0984492399655456 no 3067 0.0791674195784136 4278 88881 An O-methylated flavonoid and antioxidant. SGTC_1525 8-methoxypsoralen 92.5 µM -1.41485198883219 0.0977926592111166 no 3068 0.0785559486496425 4484 4114 Related to psoralen; DNA damaging agent. SGTC_1989 st071868 50.2 µM -1.41508143425467 0.0977565209229146 no 3069 0.0785223104854222 4421 16414057 SGTC_577 r071-0003 38.6 µM -1.416292460328 0.0975659431646511 no 3070 0.0783449472095154 4401 4568517 YMR134W ERG29 SGTC_173 1273-0061 2.693 µM -1.41920659874493 0.0971084655488306 no 3071 0.0779193963599898 4407 2847414 YPL266W DIM1 SGTC_1666 st014829 29 µM -1.42180353025856 0.096702113169922 no 3072 0.0775416472392045 4446 3858230 SGTC_1689 st020265 53.493 µM -1.4230083759642 0.0965140107674637 no 3073 0.077366863580431 4440 5758320 YPR016C TIF6 SGTC_3301 9125354 19.7965 µM -1.42318287979427 0.0964867892575833 no 3074 0.0773415736179964 4421 41905162 SGTC_2065 5221596 34.26 µM -1.42778147765978 0.0957714683876166 no 3075 0.0766773828699661 4418 788581 SGTC_409 arachidonic acid 100 µM -1.42796094265498 0.0957436315662882 no 3076 0.076651550365865 4446 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes. SGTC_2029 5175081 200 µM -1.42813307902194 0.0957169370819313 no 3077 0.0766267789765799 4418 1380876 SGTC_3235 9132602 49.47 µM -1.42851878735065 0.0956571422649665 no 3078 0.0765712954895054 4444 4912240 SGTC_1244 0416-0015 52.5 µM -1.43165327834117 0.0951722336384673 no 3079 0.0761215369137871 4432 96201 SGTC_3325 9138760 55.175 µM -1.43320716634345 0.0949325179411513 no 3080 0.075899321140982 4408 43844959 SGTC_3211 9128781 49.47 µM -1.43561196863913 0.0945624104752611 no 3081 0.0755563935597001 4392 17194361 SGTC_2887 9044784 58.44 µM -1.44279712553613 0.0934629282212911 no 3082 0.074538814573394 4394 6465546 SGTC_1745 st081495 74 µM -1.44616017619605 0.0929515657849676 no 3083 0.0740661403205896 4317 13842402 YBL026W LSM2 SGTC_2790 5423970 71.43 µM -1.45282010092564 0.0919450121529918 no 3084 0.0731368547081372 4486 1376240 YKL165C | YIL048W MCD4 | NEO1 SGTC_3130 9127414 49.47 µM -1.45352000582251 0.091839701943061 no 3085 0.0730397145998489 4493 1494646 SGTC_1663 st014140 55.4 µM -1.45484427335161 0.0916406923686155 no 3086 0.0728561891263475 4542 4207120 SGTC_2397 5161689 200 µM -1.45737560188949 0.0912611763421695 no 3087 0.0725063640497662 4498 2259942 SGTC_1409 3909-8004 61.9 µM -1.45976941844515 0.0909033504293626 no 3088 0.0721767280189856 4515 2119279 SGTC_2219 9098279 200 µM -1.46204320898254 0.0905644308303804 no 3089 0.0718646848187504 4410 902349 SGTC_2970 9090938 41.86 µM -1.46796562333009 0.089686070864942 no 3090 0.0710567804903976 4514 17217104 SGTC_64 000l-0018 272.079 µM -1.47100428629347 0.0892378692603787 no 3091 0.0706449788493643 4389 6811119 SGTC_757 1066-0008 322 µM -1.47507166989969 0.0886405430225319 no 3092 0.070096638015151 4502 6842497 SGTC_3308 9128332 17.569 µM -1.48443082947931 0.0872773976819995 no 3093 0.0688473304796576 4452 17332805 YDL196W YDL196W SGTC_2103 5378138 10 µM -1.4881031236465 0.08674683105808 no 3094 0.068361849921109 4556 244142 SGTC_187 1488-2104 32.728 µM -1.48870118024103 0.0866606536007209 no 3095 0.0682830370445902 4473 2852859 SGTC_2174 5790901 200 µM -1.49181352360082 0.0862132106324202 no 3096 0.0678740188316749 4455 786020 SGTC_994 3910-0338 138 µM -1.49185888932022 0.086206701476009 no 3097 0.0678680709771285 4542 3479481 SGTC_1440 4100-1550 40 µM -1.50128584451893 0.0848620650629456 no 3098 0.0666408223289022 4531 742806 SGTC_2990 9074105 71.4286 µM -1.50417869422994 0.0844526059931276 no 3099 0.0662676810457054 4419 6502001 SGTC_2647 atorvastatin 60.16 µM -1.50825912924886 0.0838775763602921 no 3100 0.0657441095853836 4476 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7 SGTC_1274 0865-0114 173 µM -1.51197945905654 0.083355861265754 no 3101 0.0652695440774578 4489 870624 SGTC_3332 9141069 11.198 µM -1.51245605231263 0.0832892035430467 no 3102 0.0652089423363866 4442 17332883 SGTC_704 1310-0270 142 µM -1.51432620719695 0.0830280253433191 no 3103 0.0649715624316585 4482 5718033 SGTC_3030 9087619 49.47 µM -1.51508598062039 0.0829220946257422 no 3104 0.0648753157511601 4513 25236973 SGTC_745 0469-0705 296 µM -1.51868141747856 0.0824221827244947 no 3105 0.0644213531263978 4525 3486736 SGTC_1959 st077091 55.8 µM -1.52312519875289 0.0818074560316592 no 3106 0.063863692800386 4505 821356 YKL052C ASK1 SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM -1.52376115088301 0.0817197655364803 no 3107 0.0637841937378966 4506 1377 SGTC_1329 1447-1697 50.6 µM -1.5279480552826 0.0811442075995938 no 3108 0.063262717746821 4510 2840515 SGTC_3298 9116858 71.43 µM -1.53134817804132 0.0806790605104677 no 3109 0.0628416822072116 4565 2506942 SGTC_2745 rifampicin 24.3 µM -1.53266936682792 0.0804988621278605 no 3110 0.0626786702864634 4610 25141428 Inhibits bacterial DNA-dependent RNA polymerase. SGTC_945 3381-0768 11.3 µM -1.53323134533374 0.0804223055002167 no 3111 0.062609431812466 4511 1126236 YIL048W NEO1 SGTC_2585 alliin 100 µM -1.5355958166919 0.0801008032631814 no 3112 0.0623187704135031 4547 87310 A garlic compound which reacts with lipids. SGTC_3282 9108498 15.4605 µM -1.53796280962333 0.079779932276321 no 3113 0.0620288541661008 4494 16459645 SGTC_391 gliotoxin 8.33 µM -1.54419403665334 0.0789398727445951 no 3114 0.0612706665379823 4554 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion SGTC_1457 k015-0032 57.3 µM -1.54486724471911 0.0788495171211408 no 3115 0.0611891889094181 4505 4302660 SGTC_390 dec-rvkr-cmk 16.7 µM -1.54725491468067 0.0785296841408516 no 3116 0.0609008943815211 4538 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1 SGTC_2772 vinpocetine 57.06 µM -1.55208845653933 0.0778852337347363 no 3117 0.0603205298280983 4523 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor. SGTC_1352 1496-0991 99 µM -1.55260937986781 0.0778160199237572 no 3118 0.0602582417048525 4518 3000039 SGTC_2448 5185112 27.17 µM -1.55352884581734 0.0776939666606279 no 3119 0.0601484217013497 4522 5718189 SGTC_2851 9015922 71.43 µM -1.55420220407024 0.0776046748554809 no 3120 0.060068095973279 4536 2996893 SGTC_2676 harmalol 100 µM -1.55852430144645 0.077033389993404 no 3121 0.0595545059363292 4480 5459187 A monoamine oxidase inhibitor SGTC_3033 9090887 49.47 µM -1.56330158069282 0.0764056652999781 no 3122 0.0589908383475915 4542 19325384 SGTC_3169 9102970 49.47 µM -1.56445636309992 0.0762545149444677 no 3123 0.0588552165596221 4598 17027839 SGTC_327 1273-0057 3.96 µM -1.56546357670638 0.0761228658763988 no 3124 0.0587371256597053 4441 3108138 SGTC_1002 4049-0206 172 µM -1.57236788362677 0.075225083725979 no 3125 0.0579326290335672 4495 4662749 SGTC_2528 xanthyletin 44.79 µM -1.57384316582731 0.0750343005252908 no 3126 0.0577618559501952 4556 65188 An natural product with antifungal activity of unknown mechanism. SGTC_78 0336-0123 156.75 µM -1.57605886155583 0.0747484607920876 no 3127 0.057506119313078 4386 6765896 SGTC_1950 st077106 7.18 µM -1.57641910758269 0.0747020652490882 no 3128 0.057464623853538 4444 13831864 SGTC_2462 5162487 171.77 µM -1.57643916769118 0.0746994823839936 no 3129 0.0574623138934544 4501 2259986 SGTC_1495 4469-0029 237 µM -1.57763338178609 0.0745458425671498 no 3130 0.0573249294110422 4535 793680 SGTC_3117 9124945 49.47 µM -1.58343587763004 0.0738027624962596 no 3131 0.0566610754862695 4459 17592065 SGTC_1652 st011932 78 µM -1.58678439722026 0.0733765275868425 no 3132 0.0562807419048988 4471 1551076 SGTC_1483 3453-0561 55.9 µM -1.58689234068073 0.073362818796206 no 3133 0.0562685149731536 4565 4546991 SGTC_1767 st044992 70.3 µM -1.59497084173231 0.072342400839507 no 3134 0.0553593781648235 4572 9600693 SGTC_901 1112-0062 60.1 µM -1.59544363100608 0.0722830200817643 no 3135 0.0553065328955004 4533 1908457 SGTC_607 4491-0986 66.8 µM -1.59830980341569 0.0719238376595182 no 3136 0.0549870233544482 4541 698981 YDR232W HEM1 SGTC_1447 4239-0816 81.9 µM -1.6005954194498 0.0716383914226217 no 3137 0.0547332787304203 4559 1341554 SGTC_2403 6032726 181.2 µM -1.60077628730512 0.0716158403426602 no 3138 0.054713238724897 4537 2881040 SGTC_548 1436-0017 110 µM -1.60088252633501 0.0716025967203264 no 3139 0.0547014702348236 4571 9677137 SGTC_2700 st077718 96.8 µM -1.60184752275821 0.071482387529458 no 3140 0.0545946656396705 4509 904970 SGTC_724 3910-0327 137 µM -1.60645743961146 0.0709102682177044 no 3141 0.0540867195251756 4561 2885483 SGTC_1904 st060225 78 µM -1.60655454768263 0.0708982544427683 no 3142 0.0540760599857956 4534 66595 SGTC_1957 st077035 62.4 µM -1.61386269088964 0.0699986028174206 no 3143 0.0532786064060818 4566 705593 SGTC_1760 st045453 10.4495 µM -1.61623693733927 0.0697082249626064 no 3144 0.0530215477544586 4556 3323419 YIL048W NEO1 SGTC_3079 9117512 49.47 µM -1.61631163883809 0.0696991038022893 no 3145 0.0530134758428191 4627 7185044 SGTC_429 1112-0049 25.5 µM -1.62185195637868 0.0690251806356888 no 3146 0.052417525287497 4517 2836170 SGTC_545 4218-0007 221 µM -1.63020034423744 0.0680191841617571 no 3147 0.0515295806033206 4566 2840508 SGTC_178 4092-0806 87.505 µM -1.63411056161687 0.0675519056263544 no 3148 0.0511178187885115 4451 2169044 SGTC_2325 6158266 200 µM -1.64079731401194 0.0667585785749365 no 3149 0.0504197480142992 4540 3623240 SGTC_323 4013-0906 34.3 µM -1.64253404519998 0.0665537140054051 no 3150 0.0502396882939036 4590 2910086 SGTC_2924 9010168 62.78 µM -1.64370708690326 0.0664156177487822 no 3151 0.050118360688741 4557 2993929 SGTC_809 3998-0021 90 µM -1.64391824834361 0.0663907823622625 no 3152 0.0500965451088626 4522 715485 SGTC_1241 0364-0022 50.8 µM -1.64593458117022 0.0661539968941179 no 3153 0.0498886141681216 4564 4563895 SGTC_2570 licareol 100 µM -1.64603636622988 0.0661420612629218 no 3154 0.0498781360330756 4530 443158 SGTC_1779 st039427 55 µM -1.65076057625544 0.0655899191432652 no 3155 0.0493937365525517 4562 1124498 SGTC_1213 1315-0166 115 µM -1.65501790668582 0.0650954112570722 no 3156 0.0489604328230782 4557 768401 SGTC_1636 st007707 68.9 µM -1.65589363832405 0.064994050847041 no 3157 0.0488716800822905 4585 403051 SGTC_3023 9089636 49.47 µM -1.66083592052388 0.0644243078753784 no 3158 0.0483732023771564 4644 17249241 SGTC_483 fpl-64176 144 µM -1.6632285628673 0.0641498834061567 no 3159 0.0481333460953444 4681 3423 SGTC_2612 dictamnine 15.46 µM -1.66619666446635 0.0638107203643874 no 3160 0.0478371250622437 4499 68085 A quinoline derivative and established mutagen. YOR116C RPO31 SGTC_33 0986-0033 35.816 µM -1.66628357881927 0.0638008097778928 no 3161 0.0478284729231842 4569 2848082 SGTC_1449 4112-4002 201 µM -1.66818462792499 0.0635843381313575 no 3162 0.0476395407401516 4604 2059539 SGTC_1925 st057770 10.1 µM -1.66979279408785 0.0634016635385416 no 3163 0.0474801832920998 4574 5989122 SGTC_1690 st023502 41.2 µM -1.67279113349622 0.0630621677138506 no 3164 0.047184210477292 4588 24207482 SGTC_3281 9140613 49.47 µM -1.6744417270355 0.0628758795911177 no 3165 0.0470219089448675 4563 16013766 SGTC_1513 0337-0559 19 µM -1.67644586975658 0.0626502661103714 no 3166 0.046825445283219 4552 775073 SGTC_1518 st038567 90.8 µM -1.68119208399947 0.0621184845847858 no 3167 0.0463628053022195 4547 77966 SGTC_298 1391-0729 10 µM -1.68216990617532 0.062009364909673 no 3168 0.0462679489292392 4552 3237558 SGTC_700 3453-2283 142 µM -1.68254177981288 0.0619679050999457 no 3169 0.0462319152152929 4609 565664 SGTC_3202 9113761 49.47 µM -1.6855403662884 0.0616343857966052 no 3170 0.0459421817924743 4512 4798415 SGTC_3186 9110464 49.47 µM -1.68617049709359 0.061564477722346 no 3171 0.0458814823414398 4578 17018021 SGTC_2434 5670830 169.91 µM -1.70388443707314 0.0596244807793172 no 3172 0.0442013395277924 4596 1549830 SGTC_1532 4',5'-dihydroxyflavone 78.7 µM -1.71856508726652 0.0580532679673385 no 3173 0.0428467966976913 4645 165521 SGTC_636 0kpi-0074 126 µM -1.72301581293922 0.0575834069461676 no 3174 0.0424428327509464 4617 616434 SGTC_2428 5615643 7.78 µM -1.72605980319312 0.0572637803477136 no 3175 0.0421683272171118 4593 2253075 SGTC_1874 staurosporine 7.6 µM -1.74250677533835 0.055560893813672 no 3176 0.0407099034690719 4595 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1 SGTC_3137 9097352 49.47 µM -1.7426688496726 0.0555443140750202 no 3177 0.0406957379551994 4576 44120435 SGTC_1508 1080-0625 72.9 µM -1.74635372748859 0.0551684144531359 no 3178 0.0403747526153657 4564 767111 SGTC_2028 5153890 36.43 µM -1.75055732973265 0.0547420559087959 no 3179 0.0400110953929062 4598 2830968 YPR165W RHO1 SGTC_1212 0520-0165 585 µM -1.75471605593064 0.0543228165049313 no 3180 0.0396539441380341 4628 5403258 SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM -1.75743552713206 0.0540500441985532 no 3181 0.0394218010952808 4608 6708561 SGTC_1674 st016616 23.6 µM -1.76474801289895 0.0533219520009355 no 3182 0.0388030626850582 4580 625830 SGTC_1895 st058434 18.3 µM -1.7667021104605 0.0531287077683504 no 3183 0.0386390648761331 4610 5393175 SGTC_1005 4092-0690 4.4 µM -1.77184336371998 0.0526229317144396 no 3184 0.0382102810211351 4620 1529343 SGTC_1421 4029-0249 71.4 µM -1.77462538169866 0.0523508453838445 no 3185 0.0379798817136744 4686 2894095 SGTC_1320 1313-0481 95.3 µM -1.77689734027374 0.0521294733740868 no 3186 0.0377925660431717 4584 6813365 YLR208W SEC13 SGTC_779 1360-0071 233 µM -1.78367603765119 0.0514733964473591 no 3187 0.0372381610201095 4629 7566 SGTC_2360 9040895 200 µM -1.78728892364379 0.0511264150542406 no 3188 0.0369454016561151 4634 4914414 SGTC_2619 obliquin 87.91 µM -1.79808754947793 0.0501004018134758 no 3189 0.0360815674724113 4618 6708593 A bioactive alkalod. YER133W GLC7 SGTC_3019 9081971 49.47 µM -1.81290977477163 0.0487188990127934 no 3190 0.0349228691873152 4611 16451803 SGTC_1342 1486-1464 234 µM -1.81532618002714 0.0484965927084296 no 3191 0.034736899016402 4646 3253938 SGTC_2519 cryptotanshinone 88.04 µM -1.81773025067275 0.0482762268641607 no 3192 0.0345526859008714 4642 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE) SGTC_2967 9089538 49.85 µM -1.83349741230439 0.0468507387130012 no 3193 0.0333643165193154 4616 728216 SGTC_604 1000-0114 314 µM -1.84041195575487 0.0462363472839938 no 3194 0.0328538897593087 4648 1572745 SGTC_2524 avocatin b 10.57 µM -1.84086767508997 0.0461960827008296 no 3195 0.0328204762212412 4663 6710748 SGTC_620 0109-0052 432 µM -1.84546125683268 0.0457917923882724 no 3196 0.0324852346818795 4667 493037 SGTC_3185 9108267 49.47 µM -1.85634889549652 0.0448449025965325 no 3197 0.0317019219604329 4636 4910486 SGTC_1967 st070177 51.4 µM -1.86704520369085 0.0439300670912556 no 3198 0.030947637773962 4651 5729214 SGTC_2510 benzyl isothiocyanate 8.31 µM -1.86875974738314 0.0437848349119169 no 3199 0.0308281236928293 4661 2346 DNA damaging agent; causes G2/M arrest. SGTC_2464 5717415 7.67 µM -1.87362740894201 0.0433746246114411 no 3200 0.0304908987611229 4619 5285744 SGTC_2378 9074213 121.43 µM -1.87466077823572 0.0432879404636278 no 3201 0.0304197029888566 4638 657714 SGTC_2379 9035213 200 µM -1.87980824932255 0.0428582268438658 no 3202 0.0300671078915593 4645 646551 SGTC_152 4469-0003 551.229 µM -1.88084874344526 0.042771786091687 no 3203 0.0299962486815115 4640 697280 SGTC_3091 9116372 49.47 µM -1.88211525009722 0.042666759198803 no 3204 0.0299101846040018 4670 17169793 SGTC_967 1306-0166 352 µM -1.88359556318026 0.0425442664707884 no 3205 0.0298098512336526 4641 4437607 SGTC_2952 9073731 13.78 µM -1.9007064271464 0.0411489197445353 no 3206 0.0286702381207778 4628 16457353 SGTC_2663 amphotericin b 100 µM -1.90474288706558 0.0408252250857785 no 3207 0.0284067505981245 4678 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_827 3253-0474 693 µM -1.90866706227255 0.0405125183712493 no 3208 0.0281525273787816 4666 5402065 SGTC_1012 4112-3522 18 µM -1.91517549593965 0.0399981684186297 no 3209 0.0277350631892749 4662 3112398 SGTC_741 4582-0002 126 µM -1.91586688427458 0.0399438424285818 no 3210 0.0276910208044924 4676 2912688 SGTC_3266 9136860 49.47 µM -1.92046798517359 0.0395838355983511 no 3211 0.0273994066452214 4422 4871271 YPR165W RHO1 SGTC_1801 st050089 28.441 µM -1.93643660812305 0.0383548150287941 no 3212 0.0264071247510896 4687 5008493 YIL048W | YNL267W NEO1 | PIK1 SGTC_2066 5222451 176 µM -1.94067367796726 0.0380339852830709 no 3213 0.0261489355268472 4611 2281147 SGTC_1545 lovastatin 49.4 µM -1.94673817312745 0.0375785958936383 no 3214 0.0257830663090849 4694 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12 SGTC_2119 5528445 120.635 µM -1.94800487541378 0.0374840421676513 no 3215 0.025707189893642 4677 791935 SGTC_2873 9040596 71.43 µM -1.95215604329144 0.0371755366822743 no 3216 0.0254598405781754 4644 6463863 SGTC_2275 7947463 200 µM -1.96617425980848 0.0361490346146547 no 3217 0.0246392423641996 4643 1225414 SGTC_1078 idebenone 36.1 µM -1.96930615605482 0.0359228983801854 no 3218 0.024458972349741 4700 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen. SGTC_2874 9043904 71.43 µM -1.97111794663988 0.0357926093639945 no 3219 0.024355193207777 4610 4463428 SGTC_609 0986-0026 86.3 µM -1.97183621368844 0.0357410648247519 no 3220 0.0243141534202403 4670 2848610 SGTC_2710 st078562 53.7235 µM -1.97340253504298 0.0356288728552744 no 3221 0.0242248595157269 4663 17250908 SGTC_601 0986-0029 62.9 µM -1.98334852769856 0.0349231830640767 no 3222 0.0236642561700584 4648 24747981 SGTC_515 4092-1064 102 µM -1.98695578729957 0.0346700923731931 no 3223 0.0234636482880736 4642 717353 SGTC_445 e6 berbamine 66 µM -1.98707025353329 0.0346620859754936 no 3224 0.0234573060546959 4682 6610268 A calcium/calmodulin antagonist. SGTC_2049 5262831 67.185 µM -1.99036814561037 0.0344320646031728 no 3225 0.0232751981203082 4649 763417 SGTC_1072 oxiconazole 14.9 nM -1.99499141867753 0.0341117135755745 no 3226 0.0230219079005806 4654 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_1236 0330-0013 258 µM -1.99519453927959 0.0340976955407694 no 3227 0.0230108331989366 4700 4617066 SGTC_598 3937-0236 20.2 µM -2.00271934954548 0.0335817118355421 no 3228 0.022603710351064 4731 1379313 SGTC_1261 0712-0010 12.7 µM -2.01077260632771 0.0330366293129837 no 3229 0.0221747404333904 4672 2840123 SGTC_961 1252-1571 372 µM -2.0120904956209 0.0329481263137449 no 3230 0.0221051991932045 4689 6813498 SGTC_1106 tegaserod maleate 11.7 µM -2.03003225327872 0.0317625657842528 no 3231 0.0211766304588748 4704 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation. SGTC_3280 9140961 49.47 µM -2.03012888364777 0.031756277325267 no 3232 0.0211717201296962 4697 4901226 SGTC_1505 k297-0037 20.6 µM -2.03322581167964 0.0315552812373916 no 3233 0.0210148572202144 4688 4089396 SGTC_773 4358-1457 44.6 µM -2.04579337948099 0.030750386345248 no 3234 0.0203883518443389 4688 1186886 SGTC_514 4466-0038 2.65 nM -2.06780600036699 0.0293815637208198 no 3235 0.0193291346185771 4525 5722064 SGTC_1446 4239-0190 62 µM -2.07002957769788 0.0292461520164473 no 3236 0.0192247873641524 4702 1340085 SGTC_2371 9071574 200 µM -2.12017668945753 0.026327334547278 no 3237 0.016995573736306 4724 45596039 SGTC_2651 TUB2.036 5 µM -2.12092415963758 0.0262857406942976 no 3238 0.0169640925877472 4588 15992207 YFL037W TUB2 SGTC_652 0437-0092 114 µM -2.13463650878883 0.0255323964640738 no 3239 0.0163953564307674 4697 3091274 SGTC_3144 9087057 49.47 µM -2.13609500057554 0.0254533427126965 no 3240 0.0163358355917311 4653 17249618 SGTC_2862 9027634 71.43 µM -2.15418534297147 0.0244897278384036 no 3241 0.0156128199156339 4688 5012562 SGTC_2905 7799065 20.05 µM -2.15625128328185 0.0243816557949486 no 3242 0.0155320245276689 4650 1296806 SGTC_355 1311-2252 105 µM -2.15726674984249 0.0243286823538613 no 3243 0.0154924430866429 4685 5338538 SGTC_2654 protoveratrine a 100 µM -2.16454461621986 0.0239518422129947 no 3244 0.015211288148689 4743 5702278 A heart drug and vasodilator. SGTC_1892 st058411 7.36 µM -2.1694765311538 0.0236992712215841 no 3245 0.0150232621177471 4706 3934738 SGTC_2043 5101342 149 µM -2.16986029642498 0.0236797122714881 no 3246 0.0150087154482139 4724 678451 SGTC_2000 st075254 36.4 µM -2.17707589982279 0.0233144819337458 no 3247 0.0147374524407818 4673 17234175 SGTC_3012 9080433 71.4286 µM -2.19168182984814 0.022589676048278 no 3248 0.014201244320686 4720 17688859 SGTC_1423 4048-0112 5.59 µM -2.20134560369531 0.0221206374860836 no 3249 0.0138557833702304 4761 X1423 SGTC_2787 5284540 71.43 µM -2.20190337721053 0.0220938182975771 no 3250 0.013836067196283 4713 736958 SGTC_2784 7567673 72.73 µM -2.21294364832513 0.0215685952161669 no 3251 0.0134507654709898 4657 3471247 SGTC_2993 9054257 71.4286 µM -2.22322275241016 0.0210891075855897 no 3252 0.0131003916774874 4665 6470217 YGL055W OLE1 SGTC_1099 5-nonyloxytryptamine 2.85 µM -2.2236144701831 0.0210710150274224 no 3253 0.013087197073661 4743 23581825 A 5-HT1D beta serotonin receptor agonist. SGTC_1133 3473-0247 50 µM -2.23162106181786 0.020704076430534 no 3254 0.0128200092073072 4700 711311 SGTC_2111 5486399 200 µM -2.23427711173692 0.0205835523949854 no 3255 0.0127324226849582 4696 689674 SGTC_176 1486-1328 72.834 µM -2.23664562229327 0.0204765779101134 no 3256 0.0126547553151053 4726 22310231 SGTC_2717 st081029 62.2815 µM -2.25961450717474 0.0194633990361429 no 3257 0.0119225932179726 4721 5292846 SGTC_485 niflumic acid 177 µM -2.26609909761633 0.019185185863135 no 3258 0.0117226582462675 4758 4488 A COX2 inhibitor. SGTC_2311 7694451 200 µM -2.28804942083098 0.0182683910513545 no 3259 0.0110673216220784 4726 2163142 SGTC_1059 3448-6867 171 µM -2.29552925280513 0.0179646316136933 no 3260 0.0108514059758404 4709 3934407 SGTC_1987 st072290 61.9 µM -2.30185350045851 0.0177111713803175 no 3261 0.0106717176293324 4747 54697379 SGTC_833 3852-0053 558 µM -2.31601440767884 0.0171546828448062 no 3262 0.0102787410217353 4750 3123681 SGTC_500 h-89 112 µM -2.33688703237362 0.0163617164370484 no 3263 0.00972252939793973 4718 449241 Protein kinase A inhibitor; also known to inhibit several other kinases. SGTC_2041 5107442 45.335 µM -2.35461226082295 0.0157131725399888 no 3264 0.00927102101236484 4757 793005 SGTC_1057 3448-5381 134 µM -2.35888439788426 0.0155602001082747 no 3265 0.00916498242602386 4725 5497911 SGTC_2871 9038510 12.99 µM -2.36801470521159 0.0152375509134543 no 3266 0.00894191253424207 4720 4945164 SGTC_979 1426-2828 121 µM -2.36813725514855 0.0152332595946431 no 3267 0.00893895105720957 4762 747872 SGTC_3009 9080819 71.4286 µM -2.37453137196599 0.0150107929696807 no 3268 0.00878562147624423 4757 17027216 SGTC_2588 indole-3-carbinol 100 µM -2.37871578784845 0.0148667236643751 no 3269 0.00868653257526971 4729 3712 Induces cell cycle arrest. SGTC_2697 mebhydrolin 72.4 µM -2.38734217645763 0.0145734658758697 no 3270 0.008485343802341 4734 22530 H1 Histamine receptor antagonist. YIL048W NEO1 SGTC_2782 7736369 71.43 µM -2.39231475471069 0.0144066934368463 no 3271 0.00837123869463936 4722 2950836 YOL077C BRX1 SGTC_2842 9000675 19.48 µM -2.39853378301182 0.0142004318273934 no 3272 0.00823042899369119 4702 2989072 SGTC_927 2425-1185 123 µM -2.40160617854512 0.0140994744193465 no 3273 0.00816163556527945 4733 730375 SGTC_372 0155-0182 15.9 µM -2.40375566969347 0.0140292114726401 no 3274 0.00811380757723924 4647 771486 SGTC_923 1900-2434 73.3 µM -2.40707800335359 0.0139212042187931 no 3275 0.00804036738867602 4722 5910570 SGTC_902 1120-0002 2.07 µM -2.41458045189768 0.0136799381154303 no 3276 0.00787667177504403 4752 3280475 SGTC_534 k292-0788 63.4 µM -2.42708049037632 0.0132859685639306 no 3277 0.00761043926458171 4764 4146317 SGTC_874 0599-0792 117 µM -2.44141382903552 0.0128463159667279 no 3278 0.00731493966257306 4749 765305 SGTC_2779 methotrexate 400 µM -2.44477461197293 0.0127450695127626 no 3279 0.00724713449818696 4734 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2 SGTC_54 0159-0055 9 µM -2.45860076211588 0.0123357740299092 no 3280 0.00697398148231213 4743 3319099 SGTC_53 0973-0023 39.979 µM -2.46651308307883 0.0121067070435748 no 3281 0.00682178720919246 4716 674768 SGTC_3315 9136395 68.55 µM -2.46996101851755 0.0120080462591515 no 3282 0.00675638880698709 4766 16876844 SGTC_1160 4092-0570 10.5 µM -2.47003255304565 0.0120060067421843 no 3283 0.0067550378683324 4757 4994975 SGTC_1336 1486-0901 104 µM -2.50450803337925 0.0110573795970462 no 3284 0.00613109103006207 4765 5006114 SGTC_642 0335-0876 158 µM -2.51859142192993 0.0106890299391261 no 3285 0.00589126456988685 4787 6812350 SGTC_2009 4012297 12.05 µM -2.52796739055898 0.0104497690182003 no 3286 0.0057362503568158 4730 45595307 SGTC_2880 9042983 58.44 µM -2.54257609008296 0.0100862775334027 no 3287 0.0055019319698019 4731 6464714 SGTC_2057 5236571 38.335 µM -2.54555562331027 0.010013510989808 no 3288 0.00545519900119501 4728 54684039 YBR257W POP4 SGTC_896 0964-0007 44.5 µM -2.55885737475711 0.00969421477431582 no 3289 0.00525084084912718 4745 6756758 SGTC_41 0478-0632 82.643 µM -2.58846299299497 0.0090153221605904 no 3290 0.00482026526272726 4745 3750424 SGTC_690 glyoxal 20.3 µM -2.59567770098883 0.00885633031096619 no 3291 0.00472022862198108 4645 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins. SGTC_2312 7706453 155.7 µM -2.65904708438431 0.0075622027807735 no 3292 0.00391810054444536 4757 976098 SGTC_1716 st033144 30.6155 µM -2.6613250061118 0.0075189579822293 no 3293 0.00389168938396876 4746 674617 SGTC_39 0986-0283 58.349 µM -2.68207629641182 0.00713493319431378 no 3294 0.0036583385343244 4773 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2 SGTC_1803 st050068 52.4 µM -2.68240275342351 0.00712903261078414 no 3295 0.00365476999865216 4769 3984059 YIL048W | YNL267W NEO1 | PIK1 SGTC_1377 2944-0135 198 µM -2.69496981145682 0.00690513610494917 no 3296 0.00351975043001245 4764 1894137 SGTC_2742 clothiapine 36.27 µM -2.7211258172369 0.00645895289203014 no 3297 0.0032529997012059 4785 16351 An atypical antipsychotic. YIL048W NEO1 SGTC_1293 1000-1278 195 µM -2.76923082285086 0.00570453015059035 no 3298 0.00280944061202384 4780 678847 SGTC_2582 agaric acid 100 µM -2.77317057140435 0.00564635627071688 no 3299 0.00277565073314659 4563 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase. SGTC_1374 2889-5571 141 µM -2.78423304953218 0.00548581532166337 no 3300 0.00268272336737932 4774 2853281 SGTC_726 3448-4391 34.2 µM -2.78662274381297 0.005451673042727 no 3301 0.00266302216808184 4790 1356692 SGTC_1142 3253-1408 9.78 µM -2.8021938859206 0.00523379129173774 no 3302 0.00253781797486042 4770 256655 SGTC_1109 tnp00067 928.257 nM -2.81222015279237 0.00509763053171818 no 3303 0.00246004077896497 4785 676295 SGTC_1061 3448-9325 110 µM -2.81551087721681 0.00505363358358739 no 3304 0.00243498741698768 4772 723482 SGTC_3085 9117376 49.47 µM -2.83117999414487 0.00484874237251018 no 3305 0.00231883072922235 4792 16480349 SGTC_1456 k015-0012 13 µM -2.83127716456109 0.00484749520676433 no 3306 0.00231812632285256 4783 2989616 SGTC_2276 7947513 42.08 µM -2.85457402268228 0.00455660973139527 no 3307 0.00215472938580109 4760 2105100 SGTC_1637 st007924 17.4 µM -2.8595740769122 0.0044962484308964 no 3308 0.00212105165194376 4744 683336 SGTC_2006 4011487 200 µM -2.87351650700874 0.0043316877716067 no 3309 0.00202964932286536 4744 45595294 SGTC_1050 3232-1156 69.3 µM -2.93137409369009 0.00370485554532978 no 3310 0.00168733065021208 4777 700529 SGTC_1985 st071382 65.5 µM -2.9615523449368 0.00341131263757347 no 3311 0.00153046229279212 4787 6123237 SGTC_484 loperamide 105 µM -2.96490043383183 0.00338006903603249 no 3312 0.00151390453457388 4806 3955 An opioid-receptor agonist. SGTC_2315 7733312 200 µM -2.98853954494991 0.00316669463805107 no 3313 0.0014015711153103 4764 726316 SGTC_2363 9053361 176 µM -3.00164965486172 0.00305365732582881 no 3314 0.00134260507583786 4781 6469797 YMR079W SEC14 SGTC_308 4092-1169 104 µM -3.00236124953069 0.00304762713804047 no 3315 0.00133947031860786 4777 2268590 YDL196W YDL196W SGTC_2249 haloperidol 116.36 µM -3.02195063019609 0.00288577859531957 no 3316 0.00125575753169614 4760 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_813 k007-0158 173 µM -3.0219921821802 0.00288544368918746 no 3317 0.0012555851680565 4790 6523916 SGTC_1984 st072354 53.1 µM -3.04269825720534 0.00272284919120664 no 3318 0.00117233655167945 4775 5762938 SGTC_1157 4092-0394 27.6 µM -3.05075838574882 0.00266182670120617 no 3319 0.00114132090099304 4802 3659885 SGTC_1783 st039459 87.517 µM -3.10407212973097 0.00228834816574413 no 3320 0.000954383951758159 4799 729761 SGTC_2124 5246320 200 µM -3.12626411665426 0.00214739613346548 no 3321 0.000885212349637913 4797 579342 SGTC_1672 st016598 6.51 µM -3.23041323667688 0.00158538515172984 no 3322 0.000618057077749637 4782 4665860 YNL267W PIK1 SGTC_365 0121-0052 13.6 µM -3.28780396788567 0.00133648963663461 no 3323 0.000504860604564081 4778 3101739 SGTC_2778 tioconazole 65.09 nM -3.31639099540841 0.00122633232013499 no 3324 0.00045594076238452 4753 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_3086 9117350 49.47 µM -3.33141621512115 0.00117182590117588 no 3325 0.000432026530023854 4802 2679265 SGTC_602 3130-1533 38.1 µM -3.34746557746008 0.00111606181442544 no 3326 0.000407770577142471 4804 720941 SGTC_2584 androsterone 48.74 µM -3.40057659342055 0.000948412657044741 yes 3327 0.000336219472224133 4761 2754130 A steroid. SGTC_312 4092-0653 6.84 µM -3.41586952394215 0.000904619861243246 yes 3328 0.000317893511970235 4763 1148278 SGTC_1986 st071812 45 µM -3.44239173181718 0.000833052139841314 yes 3329 0.000288297310136872 4798 11838594 SGTC_467 ro 31-8220 72.8 µM -3.4673055931877 0.000770606305047112 yes 3330 0.000262851928909917 4791 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7 SGTC_2896 9052656 71.43 µM -3.47687722024175 0.000747783723631752 yes 3331 0.000253645032746134 4566 6469436 SGTC_2684 capsaicin 100 µM -3.48409292997859 0.000730992083960644 yes 3332 0.00024690399936238 4809 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_2056 5235370 200 µM -3.49045094016428 0.000716485107043366 yes 3333 0.000241103069448358 4777 5511916 SGTC_3037 9091026 49.47 µM -3.52784284934722 0.000636404005243694 yes 3334 0.000209480404288927 4766 25236398 YIL048W NEO1 SGTC_3081 9117243 49.47 µM -3.57079487018838 0.00055465207345831 yes 3335 0.000177949772032154 4788 45595589 SGTC_304 1310-0298 97 µM -3.63409406704136 0.000451733401587821 yes 3336 0.000139479539864395 4726 1550234 SGTC_2004 4023728 41.89 µM -3.67573990765444 0.000393998767706482 yes 3337 0.000118580525436129 4798 360084 YDR527W RBA50 SGTC_1817 st052116 64.4 µM -3.68273777101992 0.000384997628263242 yes 3338 0.00011537124106021 4808 4361398 SGTC_1381 2324-0066 62.1 µM -3.72207291270048 0.000337855721388723 yes 3339 9.87969716745304e-05 4807 10885928 SGTC_2126 5251174 33.877 µM -3.77707698260257 0.000280882934260294 yes 3340 7.93398482957058e-05 4799 790722 SGTC_1679 SEC14.276 6.7 µM -3.80600803364522 0.000254639222819638 yes 3341 7.06138985158325e-05 4794 1005053 YMR079W SEC14 SGTC_1058 3448-5425 97.3 µM -3.92910338668593 0.000166525586523404 yes 3342 4.26315892192143e-05 4806 7279705 SGTC_1597 7-benzyloxygramine 47.5 µM -3.94872677920458 0.000155453138973571 yes 3343 3.92839815641027e-05 4782 260807 SGTC_964 1287-0107 19.4 µM -3.97842099386427 0.000140001408984283 yes 3344 3.46872277857612e-05 4798 51516812 YPR165W RHO1 SGTC_58 0957-0393 9 µM -4.00801073812529 0.000126044906053478 yes 3345 3.06161684224706e-05 4618 6997992 SGTC_1800 st050079 29.0735 µM -4.01981016501209 0.000120852353635038 yes 3346 2.91225273503361e-05 4783 3645560 SGTC_1712 st032288 53.4 µM -4.03255041326376 0.000115471458722824 yes 3347 2.7587386884182e-05 4766 2883011 SGTC_2640 pentamidine 10.38 µM -4.06218779613728 0.000103811321614356 yes 3348 2.43074710659328e-05 4798 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_2128 5255449 168.493 µM -4.07796030236499 9.80661812146978e-05 yes 3349 2.27162606227799e-05 4792 736008 SGTC_1368 1852-0141 284 µM -4.0951106566847 9.21588604061739e-05 yes 3350 2.10983398254289e-05 4767 2838987 SGTC_3003 9075612 71.4286 µM -4.22603778800943 5.69150863254426e-05 yes 3351 1.18921034239558e-05 4806 6501993 SGTC_1754 st042065 16.137 µM -4.23108466880732 5.58523243126526e-05 yes 3352 1.16283551085914e-05 4783 1126236 YIL048W NEO1 SGTC_1818 st052136 56.3 µM -4.33775410839627 3.73225987988589e-05 yes 3353 7.19730330042576e-06 4787 674169 SGTC_528 3492-0019 172 µM -4.38695739000461 3.08956749126343e-05 yes 3354 5.74736485909314e-06 4809 2869262 SGTC_947 3447-0010 211 µM -4.52077807828703 1.83000967886324e-05 yes 3355 3.08063760436388e-06 4802 748350 SGTC_951 1171-0579 82.7 µM -5.15499252272571 1.25948448044678e-06 yes 3356 1.26820525011556e-07 4794 1616050 YPR165W | YDR526C RHO1 | YDR526C