SGTCid condition conc unit ADH4|YGL256W.score ADH4|YGL256W.strain.pval ADH4|YGL256W.strain.significant ADH4|YGL256W.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene SGTC_1158 4092-0494 91.8 µM 5.67077158772324 4.57806248235552e-10 yes 1 7.10779107512506e-09 3 1148199 SGTC_571 k831-0106 44.2 µM 5.37199144536898 3.30280460310801e-09 yes 2 3.89359020515561e-08 4 4783639 SGTC_631 k072-0230 41.5 µM 5.29137962382559 5.53182762804838e-09 yes 3 6.06985411678881e-08 3 5773147 SGTC_2174 5790901 200 µM 4.79892056772032 1.10057993515644e-07 yes 4 7.97615201853827e-07 24 786020 SGTC_3324 9138759 60.749 µM 4.16734053206849 3.41181841501726e-06 yes 5 1.54086977837669e-05 15 45595710 SGTC_1673 st016611 27.3 µM 4.16307545129877 3.48653823471269e-06 yes 6 1.5699477714141e-05 36 5226799 SGTC_1149 3909-7961 23.3 µM 4.1247393414111 4.23217758452758e-06 yes 7 1.85577426959928e-05 15 735261 SGTC_68 0986-0284 82.829 µM 4.10803217064969 4.60279511794189e-06 yes 8 1.99522265456968e-05 65 423278 YIL048W NEO1 SGTC_2829 7992743 58.44 µM 3.97299375593745 8.96835413712402e-06 yes 9 3.5487455208917e-05 37 16462845 SGTC_252 miconazole 1.30953 nM 3.78825786500503 2.16109984992958e-05 yes 10 7.58536736726645e-05 37 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_321 4534-3890 65.3 µM 3.78040109191522 2.24157321765201e-05 yes 11 7.82879564866852e-05 5 699746 SGTC_2175 5807670 165.306 µM 3.77140011626006 2.3372580938201e-05 yes 12 8.11670681326863e-05 23 241186 SGTC_219 mitoxanthrone 164.414 µM 3.66808143276645 3.75214988867457e-05 yes 13 0.000122188678879548 59 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA.  YMR168C CEP3 SGTC_1195 1502-0147 41.1 µM 3.63343844084835 4.38586081153879e-05 yes 14 0.000139834597158752 36 817940 SGTC_976 1348-1067 47.6 µM 3.60224213871995 5.04186118553229e-05 yes 15 0.000157742144482698 42 5310671 YGL099W LSG1 SGTC_3185 9108267 49.47 µM 3.57804315874063 5.61339304283584e-05 yes 16 0.000173088149391552 27 4910486 SGTC_668 1682-0499 62.6 µM 3.51032121636386 7.55500256614745e-05 yes 17 0.000223782834581529 38 682214 SGTC_1395 3486-0190 4.35 µM 3.49473752322348 8.08367353148803e-05 yes 18 0.000237264084437634 25 6748079 SGTC_2920 7982904 15.77 µM 3.4381321119487 0.000103115335689379 yes 19 0.000292870924655732 37 6456808 SGTC_1197 1601-0112 267 µM 3.42952993090039 0.000106967936442272 yes 20 0.000302313871117927 34 7350313 SGTC_3328 9140624 29.0385 µM 3.36783543345311 0.000138823911641138 yes 21 0.000378804017184447 33 4904392 SGTC_1877 wortmannin 25 µM 3.25423518108523 0.000221895954665764 yes 22 0.000568490552584861 127 312145 A covalent inhibitor of PI 3-kinase. SGTC_882 0843-0131 351 µM 3.22817383040644 0.000246607527087172 yes 23 0.000622916216089595 36 5425421 SGTC_837 0091-0265 12.5 µM 3.17233592892189 0.000308435901644848 yes 24 0.000756089888277144 50 759367 SGTC_2260 7964312 200 µM 3.15868646786351 0.000325603273954361 yes 25 0.000792409440781408 39 231951 SGTC_2927 9011802 47.9 µM 3.15125937440072 0.000335313836824101 yes 26 0.000812840267041385 56 43912568 SGTC_1207 2099-0101 141 µM 3.09274299035928 0.000421780339275831 yes 27 0.000991579018780175 62 5837381 SGTC_1561 5-methoxyflavone 52.9 µM 3.08136954341755 0.000440821131722362 yes 28 0.0010302537305988 18 94525 SGTC_863 0466-0191 129 µM 3.07962500717078 0.000443811258293532 yes 29 0.00103630685670243 121 765160 YPR165W RHO1 SGTC_857 0438-0306 1.35 µM 3.01359994197183 0.000571806409967889 yes 30 0.0012908399611554 39 4686136 SGTC_2636 apigenin dimethyl ether 100 µM 3.0058297066826 0.000588930729494457 yes 31 0.00132428641615293 95 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_659 k018-0002 107 µM 3.00414043020556 0.000592715781051443 yes 32 0.00133166181798865 57 6797879 YHR007C ERG11 SGTC_657 3534-0529 86.7 µM 2.95754856740645 0.00070639972367762 yes 33 0.00155047947019168 49 1049549 SGTC_1044 1222-0021 1.78 µM 2.94256269006663 0.000747036950236073 yes 34 0.00162753936410948 90 4306703 SGTC_1461 k072-0203 53.8 µM 2.93485070675383 0.00076877889459441 yes 35 0.00166854102323533 59 5418714 SGTC_2168 5727979 200 µM 2.90254318373592 0.000866344949263005 yes 36 0.00185073062054017 63 695210 SGTC_2620 irigenin 100 µM 2.86367882807154 0.000998750010134339 yes 37 0.00209376182650907 94 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro. SGTC_1606 st000094 49.2 µM 2.85741958127111 0.00102173357221566 no 38 0.00213550422878346 69 1242210 SGTC_272 doxorubicin 8.13 µM 2.8555799733746 0.00102858018734123 no 39 0.00214791512377993 99 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_1124 fisetin 1.16336 µM 2.84742887559799 0.00105942610649807 no 40 0.0022036970748876 96 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster. SGTC_2394 5221648 200 µM 2.76673913651465 0.0014138762913587 no 41 0.00283100207866858 95 788586 SGTC_1763 st044482 94.5 µM 2.73100379601804 0.00160302848006237 no 42 0.00315708721802007 82 88505 SGTC_210 3551-0445 56.827 µM 2.7292499223374 0.00161288003941364 no 43 0.00317392875228122 120 2865180 YOR207C RET1 SGTC_2634 4'-methoxyflavone 100 µM 2.72386996096486 0.00164344458714543 no 44 0.00322609528438992 104 77793 From seeds of Psoralea corylifolia (Fabaceae) SGTC_865 0488-0499 301 µM 2.72248354704478 0.00165140609858986 no 45 0.00323966298404658 67 9634651 SGTC_2457 5731572 11.68 µM 2.71871388537083 0.00167323140158849 no 46 0.00327681347938841 54 2865357 SGTC_2798 7813637 45.45 µM 2.7124454158188 0.00171010636229268 no 47 0.00333943900779511 109 956368 SGTC_653 0203-0016 55.2 µM 2.71015670159867 0.0017237532941716 no 48 0.00336257134691626 84 295302 SGTC_2480 5767542 37.17 µM 2.68328813298275 0.00189154199303412 no 49 0.00364510753872429 67 2867358 SGTC_827 3253-0474 693 µM 2.65088455970864 0.00211356883128286 no 50 0.00401406379365998 92 5402065 SGTC_1765 st044815 90.4 µM 2.64178795582348 0.00218001303599772 no 51 0.00412348347683891 97 645695 SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM 2.6412764458236 0.00218380488535844 no 52 0.00412971476128875 135 551469 SGTC_290 2043-6722 48.1 µM 2.6387779414567 0.00220241248831831 no 53 0.00416027313683168 89 773758 YLR208W SEC13 SGTC_2188 6126565 140.678 µM 2.62660914045774 0.00229511026118711 no 54 0.00431201655872547 76 874518 SGTC_3166 9102297 49.47 µM 2.58792598693938 0.00261372872721159 no 55 0.00482778623594977 120 25237072 SGTC_2876 9059903 25.97 µM 2.57625682494089 0.00271740189928148 no 56 0.00499382155326714 82 6916095 SGTC_1879 gemcitabine 100 µM 2.56759803158057 0.00279671369247245 no 57 0.00512029145082997 98 60750 A nucleoside analog which inhibits DNA replication. SGTC_3233 9132340 49.47 µM 2.55708814340375 0.00289578355830365 no 58 0.00527762339332163 92 17682950 SGTC_1863 st057641 20.1 µM 2.53611888617528 0.00310295500790924 no 59 0.00560443370947375 97 3921635 SGTC_1460 k062-0059 9.15 µM 2.51974244077942 0.0032739294834431 no 60 0.00587203664712409 95 1373085 SGTC_1000 4048-0884 8.67 µM 2.51140126613567 0.00336423035869227 no 61 0.00601264598163676 124 13040088 SGTC_554 4483-2211 187 µM 2.50492527320978 0.00343587600695336 no 62 0.00612386333677347 94 747107 SGTC_2716 st080858 38.6235 µM 2.50058408392516 0.0034846681971907 no 63 0.00619943479897997 91 5296050 SGTC_891 0929-0073 133 µM 2.49255352947544 0.00357656962169746 no 64 0.00634141057850573 96 5603632 SGTC_58 0957-0393 9 µM 2.46008753828695 0.00397068641813095 no 65 0.00694515655574774 580 6997992 SGTC_2774 tamoxifen 10.92 µM 2.45120292226139 0.00408511191918684 no 66 0.00711898307502215 114 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  SGTC_2277 7947813 106.88 µM 2.44946143019146 0.00410788358054876 no 67 0.00715350158662838 142 1246798 SGTC_1157 4092-0394 27.6 µM 2.43777297047459 0.00426368330783003 no 68 0.00738902599183161 145 3659885 SGTC_1451 4152-0210 104 µM 2.43605290102769 0.00428705132729367 no 69 0.00742425640402957 139 659563 SGTC_873 0591-4978 488 µM 2.433208438566 0.00432594611274716 no 70 0.00748284143771406 117 3305145 SGTC_1885 st057546 99.9 µM 2.42995957152437 0.0043707562843526 no 71 0.00755025355965619 134 702008 SGTC_809 3998-0021 90 µM 2.42581169252513 0.00442856872119184 no 72 0.00763709666055572 87 715485 SGTC_2482 5981709 142.65 µM 2.42355131306127 0.00446036022987778 no 73 0.00768479088420371 156 877755 SGTC_811 0416-0114 265 µM 2.4129942311537 0.00461155746913184 no 74 0.00791103499768049 144 6612453 SGTC_2065 5221596 34.26 µM 2.40823047497664 0.00468126873716099 no 75 0.00801502885221731 117 788581 SGTC_2795 7780010 54.55 µM 2.38979564505829 0.00495997938235877 no 76 0.00842887490574237 142 953673 SGTC_42 0133-0086 60.653 µM 2.36665343981676 0.0053307300709146 no 77 0.00897486600206325 123 162923 Model of phenazepam hydroxylation. SGTC_1998 st075797 76.8 µM 2.35067357651778 0.00560092218857733 no 78 0.00936973257220366 148 24208315 SGTC_2486 5283202 22.39 µM 2.34699947896624 0.00566473866587327 no 79 0.00946264062344009 158 1377751 SGTC_34 0469-0683 81.75 µM 2.33676791628832 0.00584586866488744 no 80 0.00972562746587754 137 3690923 SGTC_523 1934-0222 13.7 µM 2.30110643325047 0.00651799418159588 no 81 0.0106928078972826 155 1361595 SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM 2.30013343782147 0.00653725347669634 no 82 0.0107203307034614 213 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_796 1234-0020 70.7 µM 2.28498626738942 0.00684363121139026 no 83 0.0111568165001025 150 46495034 SGTC_1517 deoxycholic acid methyl ester 49.2 µM 2.28183092595115 0.00690902680440175 no 84 0.0112496620905641 125 229346 A bile salt which induces apoptosis. SGTC_1494 4358-1428 177 µM 2.2809567384355 0.00692724199819179 no 85 0.0112755034837505 149 1564571 SGTC_2035 5154463 94.595 µM 2.27725556793195 0.00700483286148289 no 86 0.0113854842868179 169 2769623 SGTC_2252 omeprazole 400 µM 2.27600039410573 0.00703131980852472 no 87 0.0114229930131589 79 4594 A proton pump inhibitor. SGTC_687 k029-0044 34.9 µM 2.26966094153832 0.00716645140200936 no 88 0.0116140814838273 138 5829338 SGTC_2967 9089538 49.85 µM 2.24611545757531 0.00768861092964676 no 89 0.0123483067487085 184 728216 SGTC_880 0833-0487 87.2 µM 2.23369650970925 0.00797728739611279 no 90 0.0127515244077893 156 76075 SGTC_3245 9134821 49.47 µM 2.23050169814101 0.00805307432342881 no 91 0.0128570774233135 174 17014901 SGTC_364 0083-0097 67.7 µM 2.22789772916834 0.00811531276097348 no 92 0.012943667826746 161 5207356 SGTC_674 0498-0004 451 µM 2.22145974987483 0.00827100709236411 no 93 0.0131599189922655 170 4231473 SGTC_1422 4031-0024 15.5 µM 2.21685415117397 0.00838399146581148 no 94 0.0133165298477858 130 782427 SGTC_3084 9116877 49.47 µM 2.20137372107808 0.00877374854237538 no 95 0.0138547888976235 96 27241325 SGTC_738 1315-0003 72.4 µM 2.18630580060563 0.00916828337449986 no 96 0.0143966200248641 177 6251474 SGTC_1655 st012546 55.1 µM 2.18475683233574 0.00920970838155709 no 97 0.0144533403510296 163 720985 YLR208W SEC13 SGTC_1066 ketoconazole 628 nM 2.17990004167728 0.00934066049752098 no 98 0.014632435926005 182 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W SGTC_62 0180-0423 3.232 µM 2.1752659583414 0.00946712354752141 no 99 0.0148050959777287 166 30102 YGL099W LSG1 SGTC_3010 9080089 71.4286 µM 2.16612769109668 0.00972089838284619 no 100 0.0151507153526435 162 17027233 SGTC_1738 st035555 74 µM 2.16516531284985 0.00974796698660155 no 101 0.0151875138416526 210 5331140 SGTC_3073 9114972 49.47 µM 2.16391710149522 0.00978317322943545 no 102 0.0152353560981693 150 41905075 SGTC_2110 5483698 200 µM 2.16348540616641 0.00979537517183609 no 103 0.0152519324985415 163 2848765 YHR062C RPP1 SGTC_1135 dihydrocapsaicin 536.708 nM 2.15462687626759 0.0100487147389175 no 104 0.0155955220678725 203 107982 A Capsaicinoid. SGTC_769 0302-0231 76 µM 2.1535909395174 0.0100787110836702 no 105 0.0156361327202106 255 571869 YER009W NTF2 SGTC_611 3453-1652 23.7 µM 2.15344252843878 0.0100830148330495 no 106 0.0156419581354934 206 1560575 SGTC_1453 4237-0541 195 µM 2.1378165115008 0.0105452191245924 no 107 0.0162658191858235 182 739892 SGTC_3014 9081533 49.47 µM 2.13625388570955 0.0105924400518484 no 108 0.0163293627038503 148 21367265 SGTC_2176 5809774 33.9695 µM 2.13456678923568 0.0106436290452241 no 109 0.016398206320146 159 2870539 SGTC_2918 7977171 22.06 µM 2.12400636924233 0.0109689693250122 no 110 0.0168348054922934 175 2236483 SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM 2.12165861530304 0.0110424622933467 no 111 0.0169332081444549 255 368090 SGTC_3100 9120536 49.47 µM 2.11962229542904 0.0111065527610399 no 112 0.0170189553566705 107 16421196 SGTC_1855 st056195 39.6 µM 2.11307334234729 0.011314870478741 no 113 0.0172972454635453 187 4028379 SGTC_1294 1000-1494 117 µM 2.10539979984085 0.0115632736816063 no 114 0.017628260607027 195 712797 YDL207W GLE1 SGTC_2863 9028737 58.44 µM 2.06859216854644 0.0128217108515367 no 115 0.0192921867277845 137 6460917 SGTC_637 1181-0519 7.26 µM 2.06771214626103 0.0128531947326035 no 116 0.0193335495362544 322 6252091 YGR060W ERG25 SGTC_600 1495-0418 41.6 µM 2.06121766862425 0.0130876170500613 no 117 0.0196411393195814 184 5377768 SGTC_5 0352-0601 109.883 µM 2.04105959746842 0.0138389193880353 no 118 0.0206224518191133 149 762456 SGTC_990 3985-0011 41.3 µM 2.02868554289743 0.014318297282518 no 119 0.0212451646716344 179 5399565 YGL099W LSG1 SGTC_2387 9077560 195.08 µM 2.02596401535142 0.0144256286897832 no 120 0.0213842361656063 206 5303272 SGTC_2239 6685329 187.64 µM 2.01129911831002 0.0150159809126469 no 121 0.0221469357917587 232 805680 SGTC_307 1501-1223 22.3 µM 2.003668624543 0.015331286259313 no 122 0.0225527846851808 187 2830329 SGTC_2200 6600604 21.907 µM 1.99411760089019 0.0157339492349713 no 123 0.0230696020905984 254 2904777 SGTC_1638 st008370 60.6 µM 1.99283716119166 0.0157886150778908 no 124 0.0231396405455737 257 24207134 SGTC_356 1634-0012 32.5 µM 1.98520484633545 0.0161178524076006 no 125 0.0235608426735011 238 735457 SGTC_1873 rapamycin 2 nM 1.98400426857384 0.0161701739030294 no 126 0.0236276820387067 289 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1 SGTC_1128 3448-9350 235 µM 1.97675399318162 0.0164892455662506 no 127 0.024034722196257 229 619386 SGTC_2629 bisabolol 100 µM 1.97405670655978 0.0166093161973834 no 128 0.0241876476833413 254 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer. SGTC_1275 0867-0008 21.1 µM 1.96952462644653 0.0168127481359083 no 129 0.0244464387442129 226 3422836 SGTC_1848 st056003 16.4 µM 1.96755521434038 0.0169018113961905 no 130 0.0245596185296864 220 146492 SGTC_268 camptothecin 39.6153 µM 1.96235041967666 0.0171391334871488 no 131 0.0248608504417608 356 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_599 1935-0052 86.5 µM 1.95984341020575 0.017254457614927 no 132 0.0250070478081091 232 9557311 SGTC_2205 7238770 200 µM 1.94810364075408 0.0178033550715638 no 133 0.025701281638744 162 279867 SGTC_3136 9095672 49.47 µM 1.94320496295533 0.0180367612714605 no 134 0.0259956993458752 207 17217380 SGTC_2434 5670830 169.91 µM 1.9426771970646 0.0180620625920114 no 135 0.0260275865331226 262 1549830 SGTC_2954 9074818 52.69 µM 1.94249856856843 0.0180706329684748 no 136 0.0260383865299245 266 16648742 SGTC_1405 3909-7894 12 µM 1.94037192855442 0.0181729331544906 no 137 0.0261672527910909 223 7104060 SGTC_2879 9041815 71.43 µM 1.93575221420886 0.0183968622381524 no 138 0.0264490280428338 119 4942971 SGTC_2275 7947463 200 µM 1.9320862368083 0.0185762298791932 no 139 0.0266744313963425 210 1225414 SGTC_1584 6-fluoro-dl-tryptophan 90 µM 1.9217875900401 0.0190881039316367 no 140 0.0273162452449538 254 94937 An inhibitor of serotonin biosynthesis. SGTC_1150 3909-7983 10.9 µM 1.9144894805366 0.0194580606747854 no 141 0.0277788209887653 282 23965914 SGTC_2777 climbazole 1.536 µM 1.91418095417052 0.0194738338049234 no 142 0.0277985192253894 282 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2 SGTC_2126 5251174 33.877 µM 1.90866344505045 0.0197577505638077 no 143 0.0281527608413077 326 790722 SGTC_2474 5321570 43.32 µM 1.90491562721486 0.0199526011125211 no 144 0.0283955197683099 207 2841384 SGTC_84 0443-0269 128.823 µM 1.90073021402909 0.02017212704669 no 145 0.0286686794542263 259 6150058 SGTC_2256 7954252 200 µM 1.89820559473254 0.0203055316721834 no 146 0.0288345020565469 184 2972920 SGTC_1309 pyrazolanthrone 13.4 µM 1.89107248254149 0.0206865039964068 no 147 0.0293073346137943 264 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14 SGTC_2246 7293507 91.5585 µM 1.88548367631346 0.0209892103053091 no 148 0.0296822831356814 265 887656 SGTC_2685 mycophenolic acid 18.85 µM 1.88514855923213 0.0210074797530407 no 149 0.0297048917955761 190 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_1085 doxorubicin 7.67 µM 1.88480930840975 0.0210259882636828 no 150 0.0297277938910409 303 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_716 1683-5115 658 µM 1.88369624300836 0.0210868107203934 no 151 0.0298030374607776 298 723597 SGTC_2024 5144227 134 µM 1.88201749961148 0.0211788256737962 no 152 0.029916819829917 290 3475211 SGTC_2972 9093619 59.92 µM 1.88139961382649 0.0212127785119211 no 153 0.0299587896834456 253 25236256 SGTC_924 2046-0044 21.3 µM 1.88008147634812 0.0212853640895956 no 154 0.0300484872974924 241 3623589 SGTC_1843 st055809 45.5 µM 1.8786883904533 0.0213623050212286 no 155 0.0301435269729899 236 16413835 SGTC_3292 9120825 59.784 µM 1.87620959143398 0.0214997920181407 no 156 0.0303132527760745 242 24824900 SGTC_901 1112-0062 60.1 µM 1.87436768615176 0.021602437305321 no 157 0.0304398820706248 214 1908457 SGTC_2468 5987765 72.9 µM 1.85972720010626 0.0224331395814213 no 158 0.0314620658491305 248 26772094 SGTC_630 4356-0227 183 µM 1.85749027814926 0.0225624052392225 no 159 0.0316207165331427 221 779312 SGTC_23 0213-0011 39.996 µM 1.85582354122441 0.0226591292439879 no 160 0.0317393569684166 258 627608 SGTC_357 1325-0123 420 µM 1.84941165881171 0.0230344880750129 no 161 0.0321991966093927 223 1098503 SGTC_3204 9114183 49.47 µM 1.84157405945181 0.0235004096160926 no 162 0.0327687391853454 272 17027248 SGTC_2462 5162487 171.77 µM 1.83942187141071 0.0236297295011854 no 163 0.0329265798139642 255 2259986 SGTC_173 1273-0061 2.693 µM 1.83608092887365 0.0238316641941238 no 164 0.0331728442029963 402 2847414 YPL266W DIM1 SGTC_2193 5925765 200 µM 1.83187652997479 0.0240878479065947 no 165 0.0334849089942887 204 877370 SGTC_844 0330-0132 15.3 µM 1.83112286163056 0.0241340143288221 no 166 0.033541103464887 263 2828079 SGTC_2334 9017922 200 µM 1.82750092306936 0.0243569165891126 no 167 0.0338122437719692 260 3163164 SGTC_1496 4469-0713 57.4 µM 1.82738452792674 0.024364108379785 no 168 0.0338209869943486 264 746691 SGTC_3323 9138564 53.9225 µM 1.82339068728023 0.0246119609872581 no 169 0.0341221198874595 306 43912313 YNL103W MET4 SGTC_2764 methyldopa 94.69 µM 1.8195978120828 0.0248492972473413 no 170 0.0344101375605296 294 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent. SGTC_2046 4110841 106 µM 1.81518194607173 0.0251280319358594 no 171 0.0347479766101123 267 44119630 YMR134W ERG29 SGTC_744 1594-0068 283 µM 1.81461962261428 0.025163713835761 no 172 0.0347911924157647 327 668392 SGTC_2718 lomofungin 53.02 µM 1.81124664546558 0.0253786364537693 no 173 0.0350513403213253 243 5351222 A RNA synthesis inhibitor. SGTC_1789 tunicamycin 25 nM 1.80515367526804 0.0257707719038468 no 174 0.0355253188518825 291 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_3118 9124250 49.47 µM 1.80044201215942 0.0260774739217679 no 175 0.0358954360628038 249 1504786 SGTC_230 MPP+ 141.667 µM 1.79327829610162 0.0265496356847922 no 176 0.0364642180178819 274 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death. SGTC_1996 st072960 66.8 µM 1.79235693148947 0.0266108781936249 no 177 0.0365379045388615 285 1719405 SGTC_567 1080-0542 68.4 µM 1.78853883492871 0.0268659237577532 no 178 0.0368445579911896 248 5950415 SGTC_3001 9076041 71.4286 µM 1.78175770893174 0.0273239278030161 no 179 0.0373943757763229 263 16004211 SGTC_3013 9080133 71.4286 µM 1.76622747491749 0.0283974302514571 no 180 0.0386788466866823 334 17050193 SGTC_773 4358-1457 44.6 µM 1.76518767209939 0.0284705413067643 no 181 0.0387661149028692 354 1186886 SGTC_2730 imipramine 71.33 µM 1.76276406427414 0.028641559095707 no 182 0.0389701453223171 365 3696 A tricyclic antidepressant. SGTC_418 lividomycin a 100 µM 1.76119207036496 0.0287529403208388 no 183 0.0391029498628275 275 72394 An antibiotic. SGTC_2250 alverine citrate 130 µM 1.7601254694269 0.0288287175896481 no 184 0.0391932676204029 514 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1 SGTC_3117 9124945 49.47 µM 1.7592324644516 0.0288922892571394 no 185 0.0392690161214031 228 17592065 SGTC_644 1498-1197 63.3 µM 1.74988159257349 0.0295649885682951 no 186 0.0400693737975861 329 6741615 SGTC_3142 9086498 49.47 µM 1.74404782502656 0.0299912162845527 no 187 0.0405753753992502 292 25236367 SGTC_1917 st066507 28.5 µM 1.74216295725613 0.0301300132203163 no 188 0.0407399668776504 374 3156428 SGTC_2049 5262831 67.185 µM 1.74067056343898 0.0302402867236285 no 189 0.0408706704806583 304 763417 SGTC_1414 3917-0015 5.4 µM 1.73946425497211 0.0303296655621508 no 190 0.0409765672152049 251 6618702 SGTC_3353 9151644 39.2805 µM 1.73107247308905 0.0309575130400967 no 191 0.041719419621296 299 4909158 SGTC_517 1365-0151 113 µM 1.72027831701311 0.0317808763005708 no 192 0.0426909314526781 314 768657 SGTC_1506 4226-2149 212 µM 1.71259075710326 0.0323782365182318 no 193 0.0433939274543537 375 991114 SGTC_864 0469-0573 172 µM 1.71115560532006 0.0324907745462409 no 194 0.0435261957804906 305 689425 SGTC_2915 7971052 15.16 µM 1.7070624418706 0.0328135153283479 no 195 0.0439052235186564 209 5741558 SGTC_1872 amphotericin b 148 nM 1.70605344575937 0.0328934781546858 no 196 0.0439990645980134 319 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1 SGTC_2769 toremifene 3.73 µM 1.7005544591835 0.033332099868898 no 197 0.0445133409549223 307 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_1375 2910-0797 186 µM 1.67960528991611 0.0350474312472291 no 198 0.0465170688894281 331 742508 SGTC_2748 diazoxide 86.69 µM 1.674342634107 0.0354895417414459 no 199 0.0470316400255973 259 3019 A potassium channel activatior. SGTC_1194 1488-0194 225 µM 1.67120107501907 0.035755633570175 no 200 0.0473409840013897 386 1391452 SGTC_180 1486-1293 102.781 µM 1.66950474274158 0.0358999922517543 no 201 0.047508695624741 331 4140536 SGTC_1420 4'-methoxyflavone 42 µM 1.6693247858739 0.0359153346404392 no 202 0.047526515347067 303 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13 SGTC_256 clotrimazole 625 nM 1.66820505766061 0.0360109188326355 no 203 0.0476375136204529 342 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C SGTC_3193 9111931 49.47 µM 1.663196224826 0.0364410453681898 no 204 0.0481365815453382 338 17087244 SGTC_2934 9036370 36.88 µM 1.65821780347837 0.0368727173957193 no 205 0.0486367562816947 386 6462800 SGTC_2160 5660466 132.927 µM 1.65496480856014 0.0371570320261525 no 206 0.0489658182947667 325 2859134 SGTC_1040 k898-0338 155 µM 1.6418873915001 0.0383181399487866 no 207 0.0503066716643359 391 20969351 SGTC_2962 9082311 13.18 µM 1.63188790748241 0.0392257834789123 no 208 0.0513515509560535 330 16459453 SGTC_140 0062-0056 502.533 µM 1.63179891015563 0.0392339395621908 no 209 0.0513609275009284 395 3758964 SGTC_939 1165-0479 45.3 µM 1.63063820943163 0.0393404374114717 no 210 0.0514833408884479 386 1377347 SGTC_2976 9009005 19.48 µM 1.62995039282946 0.0394036576077907 no 211 0.0515559909313916 346 2993148 SGTC_386 1509-0011 3.07 µM 1.62887651944356 0.0395025271929755 no 212 0.0516695808569276 466 3107280 SGTC_3330 9141424 71.43 µM 1.6286125802177 0.0395268584695746 no 213 0.0516975297037136 390 27261020 SGTC_993 3909-8757 62.7 µM 1.62750204707153 0.0396293667100649 no 214 0.0518152570980387 303 4288324 YLR208W SEC13 SGTC_2089 5281248 129.67 µM 1.62665334944597 0.0397078517627067 no 215 0.0519053709206883 358 2737878 SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM 1.62207907387385 0.040133046233624 no 216 0.0523932090852414 372 2333 A French combination drug. SGTC_257 daunorubicin 18.5 µM 1.62025015743439 0.0403040820922854 no 217 0.0525892754698912 308 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_1054 3429-0080 167 µM 1.61981127578212 0.0403452131977796 no 218 0.0526364116805947 399 1162877 SGTC_2472 5377652 49.4 µM 1.61745517712909 0.0405666050788353 no 219 0.0528900317855407 418 1610903 SGTC_96 0929-0093 37.281 µM 1.6075600699558 0.0415071942728402 no 220 0.0539657816718866 348 6991579 SGTC_204 PMA1.184 62.41 µM 1.60373667283117 0.0418753315368829 no 221 0.0543860543304855 404 2252213 YGL008C PMA1 SGTC_249 wiskostatin 11.211 µM 1.60296737342712 0.0419497223689912 no 222 0.0544709287618597 343 2775510 A n-wasp and actin depolymerizer. SGTC_2655 perillic acid 100 µM 1.60234382524507 0.0420100976100737 no 223 0.0545397997519752 286 5702197 An apoptosis inducer. SGTC_1930 st074634 34.3 µM 1.59652868113506 0.0425765437953751 no 224 0.0551854037730585 394 684253 YOR116C RPO31 SGTC_3040 9091894 49.47 µM 1.59642193008765 0.0425869997302126 no 225 0.0551973115800015 296 25236966 SGTC_1938 st074717 56.4 µM 1.59468841286805 0.0427570831738738 no 226 0.0553909652207094 314 17250979 SGTC_1866 st057638 64 µM 1.59465608662966 0.0427602600589687 no 227 0.0553945815189217 345 688802 SGTC_763 3453-1109 128 µM 1.59451936078673 0.0427736990029523 no 228 0.0554098789397073 384 1560353 SGTC_2536 dehydroabietamide 32.04 µM 1.59050438094467 0.0431698605136239 no 229 0.0558605794558172 406 3983547 SGTC_502 l-744,832 89.3 µM 1.58830107090874 0.0433885192349758 no 230 0.0561091377328667 381 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.  SGTC_3199 9111318 49.47 µM 1.5805817913824 0.0441616512987928 no 231 0.0569868459446973 377 8548020 SGTC_1591 genipin 88.4 µM 1.58057796925882 0.0441620368402614 no 232 0.0569872831953241 327 442424 A DNA cross-linking agent. SGTC_2449 5812982 45.77 µM 1.57920974735829 0.0443002252052966 no 233 0.0571439774641866 327 776185 SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM 1.57476534660563 0.0447515091660713 no 234 0.0576553089877509 369 4213774 SGTC_766 1391-0721 126 µM 1.57357172285257 0.0448733381514777 no 235 0.0577932474136256 378 1020919 YIL115C NUP159 SGTC_3313 9133968 57.047 µM 1.57225168730267 0.0450083803246538 no 236 0.0579460963217392 398 1494643 SGTC_2598 perillyl alcohol 100 µM 1.56838116328074 0.0454062288327538 no 237 0.0583961022367217 397 10819 An apoptosis inducer. SGTC_1979 st071809 45.3 µM 1.5633808816267 0.0459243862945683 no 238 0.0589815171280728 371 4976333 SGTC_2318 6029776 164 µM 1.56238511302213 0.0460281385835762 no 239 0.0590986460002938 405 818325 SGTC_292 k038-0015 474 µM 1.56210450998727 0.0460574094862482 no 240 0.0591316853091235 355 46368540 SGTC_3004 9076122 71.4286 µM 1.55762041062195 0.046527196861016 no 241 0.0596616286855382 405 44782551 SGTC_1021 4476-0760 85.3 µM 1.55492428040355 0.0468115097363658 no 242 0.059982051962498 409 746768 SGTC_1332 1480-0653 17.5 µM 1.55369311044392 0.0469418019948497 no 243 0.060128818622524 402 5749438 SGTC_2929 9013348 24.6 µM 1.55299885159119 0.0470154021646873 no 244 0.0602117044844937 401 2995952 SGTC_28 pentachloropyridine N-oxide 1.606 µM 1.5516600129862 0.0471575971581803 no 245 0.0603717976681166 388 140250 A respiratory chain inhibitor. SGTC_670 4204-0025 119 µM 1.55039170736539 0.0472926187917017 no 246 0.0605237638613801 422 719039 SGTC_2625 euphol 100 µM 1.5480760659828 0.0475399370997301 no 247 0.0608019918679544 447 6708538 A triterpene alcohol. SGTC_117 lucigenin 22.078 µM 1.54499375557045 0.0478707444359833 no 248 0.0611738868958049 473 65100 An acridine derivative; a dye stuff and potential carcinogen. SGTC_145 3737-0113 38.366 µM 1.54410562179049 0.047966404164234 no 249 0.0612813735858848 513 6849351 SGTC_2071 5230951 39.92 µM 1.54371738557643 0.048008268612401 no 250 0.061328406330984 418 1799272 SGTC_1310 1188-0297 994 nM 1.54239007965073 0.0481516161543759 no 251 0.0614894154018861 412 1588352 SGTC_393 acivicin 6.25 µM 1.54227019124149 0.0481645808138122 no 252 0.0615039747276084 363 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1 SGTC_3 0833-0587 95.581 µM 1.54101292581568 0.0483007090226618 no 253 0.0616568200666872 372 5382644 SGTC_779 1360-0071 233 µM 1.5373196824241 0.0487023690226468 no 254 0.0621075219497939 431 7566 SGTC_41 0478-0632 82.643 µM 1.53595516201355 0.0488514416447562 no 255 0.0622746888284766 470 3750424 SGTC_508 roscovitine 141 µM 1.53593438069776 0.048853714800488 no 256 0.0622772374499137 348 160355 A CDKinase inhibitor. SGTC_3310 9130229 44.1445 µM 1.53441694412058 0.049019927531482 no 257 0.0624635558740156 379 7761258 SGTC_154 3389-1638 511.116 µM 1.5303440075517 0.049468291702383 no 258 0.062965800333008 357 5238686 SGTC_2745 rifampicin 24.3 µM 1.52375962968548 0.050200041976622 no 259 0.0637843838077694 237 25141428 Inhibits bacterial DNA-dependent RNA polymerase. SGTC_2928 9011484 9.79 µM 1.52125785387499 0.0504803269308751 no 260 0.0640975711218278 371 2994751 SGTC_846 0335-0850 148 µM 1.51986767371856 0.0506366130040901 no 261 0.0642721182254123 368 6819598 SGTC_2646 retinol 96.75 µM 1.51714705102165 0.0509435843258624 no 262 0.0646147805995815 398 445354 A vitamin A analog and teratogen. SGTC_728 3030-5151 22.5 µM 1.51496436572532 0.0511909289267504 no 263 0.064890714253966 373 3125388 SGTC_1279 0874-0590 65.2 µM 1.51402139253181 0.0512980829737977 no 264 0.0650102069238571 414 3523074 SGTC_2958 9077254 16.72 µM 1.51360053352171 0.0513459645238009 no 265 0.065063592870784 379 16457351 SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM 1.51131543249802 0.0516065636003128 no 266 0.0653540519449707 392 689007 SGTC_3106 9121286 49.47 µM 1.51076600554519 0.0516693782857962 no 267 0.0654240393492356 354 15943471 SGTC_1257 0669-0121 16 µM 1.51031397447234 0.0517211034922776 no 268 0.0654816637942162 485 4307855 SGTC_1314 1222-0010 41.1 µM 1.50701177375102 0.0521002188446736 no 269 0.065903819671446 386 3526027 SGTC_1450 4112-4260 37.6 µM 1.50694764296432 0.0521076032927001 no 270 0.0659120390293047 427 1633175 SGTC_1004 4084-0029 199 µM 1.50658667571028 0.0521491829891454 no 271 0.065958317417878 454 716894 YLR208W SEC13 SGTC_983 1491-0821 12.2 µM 1.50650623893635 0.052158452063656 no 272 0.0659686333737664 377 46495113 SGTC_458 nppb 133 µM 1.50586599593713 0.0522322766783142 no 273 0.0660507886417526 358 4549 A chloride channel blocker. SGTC_2789 5281112 71.43 µM 1.5032319104685 0.0525368790331388 no 274 0.0663896257163118 436 765948 SGTC_1355 1499-0035 1.68 µM 1.50075183471141 0.0528249589582711 no 275 0.0667098803411229 420 1548538 SGTC_2717 st081029 62.2815 µM 1.50048185299142 0.0528563949054979 no 276 0.0667448153786959 377 5292846 SGTC_1697 st025554 27.742 µM 1.50020455216194 0.0528886985170729 no 277 0.0667807122288408 385 1269519 SGTC_2594 a-mangostin 100 µM 1.49970562167018 0.0529468598718804 no 278 0.0668453368609005 454 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis. SGTC_2164 5685496 200 µM 1.49796645103195 0.0531499952687886 no 279 0.0670709835663378 429 759046 SGTC_288 1315-0019 35.1 µM 1.49755934488652 0.053197634462245 no 280 0.0671238880756357 426 6811474 SGTC_1125 tnp00248 1.32998 µM 1.49633378321166 0.0533412529467604 no 281 0.0672833478296775 531 24207736 SGTC_449 xestospongin c 11.1929 µM 1.49459420508556 0.0535456343398904 no 282 0.0675101897186261 447 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1 SGTC_2690 usnic acid 100 µM 1.49409085153403 0.0536048884647484 no 283 0.0675759374056966 506 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_3021 9087658 49.47 µM 1.49048388633072 0.0540310168127116 no 284 0.0680485251207487 354 25237042 SGTC_1139 k015-0024 46.9 µM 1.49023799456754 0.0540601639172981 no 285 0.0680808347419378 388 2766652 SGTC_842 0271-0008 11.1 µM 1.48491970651657 0.0546936248942117 no 286 0.0687825475489663 463 1221709 SGTC_3139 9095020 49.47 µM 1.47963681453665 0.0553286656164391 no 287 0.0694850981217429 303 25236292 SGTC_641 4092-0595 30 µM 1.47757625098109 0.0555779327217755 no 288 0.0697606174635525 457 786260 SGTC_803 4488-1585 147 µM 1.47265329782945 0.0561770530655109 no 289 0.0704222727592429 385 747204 SGTC_2894 9048625 32.47 µM 1.46987690412988 0.056517177539246 no 290 0.0707975479040263 414 4092861 SGTC_2875 9039966 71.43 µM 1.46977019910098 0.0565302818404988 no 291 0.0708120014404418 367 6463691 SGTC_2197 6588183 93.1375 µM 1.46851285895242 0.0566848744812666 no 292 0.070982482960211 376 884136 SGTC_3039 9090270 49.47 µM 1.46836609098383 0.0567029416005763 no 293 0.0710024036148848 395 17173750 SGTC_1492 4158-0558 28.5 µM 1.46813747111652 0.0567310937149541 no 294 0.0710334424907581 409 3967268 SGTC_1137 ixabepilone 100 µM 1.46513848783173 0.0571014070734142 no 295 0.0714415689281063 490 154225 A novel microtubule stabilizer. SGTC_874 0599-0792 117 µM 1.46458783619503 0.0571696076424264 no 296 0.071516701322094 513 765305 SGTC_2845 9003024 42.97 µM 1.46320666090435 0.057340954228669 no 297 0.0717054193633785 460 2990173 SGTC_1798 st045719 60.953 µM 1.46224518402872 0.0574604720160026 no 298 0.0718370169214453 379 3980186 SGTC_1224 0823-0416 294 µM 1.46211202332669 0.0574770401906343 no 299 0.0718552572503749 438 3598164 SGTC_998 3996-0085 177 µM 1.4617145223123 0.0575265205761043 no 300 0.0719097279944557 483 715391 SGTC_224 benfluorex 43.875 µM 1.46125787138952 0.05758340521018 no 301 0.0719723433020682 310 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis. SGTC_789 1309-1135 70.6 µM 1.45931481100524 0.0578259454246691 no 302 0.0722392403704914 469 3092424 SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM 1.45696879499707 0.0581198535053665 no 303 0.0725624970946026 493 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis. SGTC_1834 st055981 52.8 µM 1.45610848950782 0.0582279259536154 no 304 0.0726813155376553 448 471719 YDL150W RPC53 SGTC_179 1273-0063 6.77 µM 1.45319351445455 0.0585952821087488 no 305 0.0730850161859829 382 3108139 SGTC_316 k060-0003 58.6 µM 1.45053408437891 0.058932018484143 no 306 0.0734548207529845 431 6152314 SGTC_1199 1638-0010 4.46 µM 1.4485110681334 0.0591891876237595 no 307 0.073737086409695 491 3111136 SGTC_1270 0831-1170 17.3 µM 1.44597697243565 0.0595125667794435 no 308 0.074091830358473 486 6764716 SGTC_328 k915-0120 63.5 µM 1.44198929397221 0.0600242416001354 no 309 0.0746526969334998 428 6624543 SGTC_2763 lisinopril 49.32 µM 1.43619392445004 0.0607740020486485 no 310 0.0754735836808208 408 5362119 A lysine-analog of enalapril and an ACE inhibitor. SGTC_1886 st057356 49.9 µM 1.43101879115304 0.0614496931641395 no 311 0.0762124148419378 434 24207747 SGTC_547 1120-0019 610 nM 1.42882273510345 0.0617381884779664 no 312 0.0765275946540609 464 3676939 SGTC_281 1672-3440 14.9 µM 1.428473341471 0.0617841855696673 no 313 0.0765778312134711 490 6833000 SGTC_1167 k781-0610 148 µM 1.42530317285707 0.0622027564447012 no 314 0.077034791692212 502 4525169 SGTC_452 diindolylmethane 8 µM 1.4240596190708 0.0623675509092494 no 315 0.0772146072253291 398 3071 Inhibits expression of several cancer promoting factors. SGTC_438 sphingosine 6.67 µM 1.42330058828029 0.0624683040876964 no 316 0.0773245182658894 377 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes. SGTC_3007 9078383 71.4286 µM 1.42207268672854 0.0626315634669254 no 317 0.0775025754633589 458 6496995 SGTC_2828 7998861 71.43 µM 1.41908440974776 0.0630302684148052 no 318 0.0779372042833262 371 2988188 SGTC_1043 0916-0009 19.3 µM 1.41877327952123 0.063071893726265 no 319 0.0779825625976767 572 3101130 SGTC_2314 7727897 200 µM 1.41862983013839 0.0630910926594545 no 320 0.0780034822005738 451 900724 SGTC_1236 0330-0013 258 µM 1.41764842390455 0.063222563908847 no 321 0.0781467174946531 443 4617066 SGTC_3024 9090631 49.47 µM 1.41632428677841 0.0634002860623546 no 322 0.078340290102326 416 25236383 SGTC_255 tunicamycin 200.472 nM 1.41337198786919 0.0637979356796626 no 323 0.0787731887548965 492 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_436 n,n-dimethylsphingosine 3.3 µM 1.41152897995243 0.064047155050014 no 324 0.0790443483816592 479 5282309 SGTC_1163 k060-0048 49.9 µM 1.40856160258788 0.0644500060869401 no 325 0.0794824197187102 513 6809982 SGTC_2037 5169046 200 µM 1.40833539989263 0.0644807959316919 no 326 0.0795158890440386 440 5718022 SGTC_2093 5331342 194.4 µM 1.40706990530902 0.0646532610564359 no 327 0.0797033304796407 484 33839 SGTC_1482 3346-2049 8.48 µM 1.40604448165579 0.0647932712366415 no 328 0.0798554582963349 464 3826804 SGTC_1631 benzylvanillin 81.9 µM 1.40555187750186 0.0648606145076976 no 329 0.0799286171485075 499 75506 SGTC_1726 st035556 14.5795 µM 1.40534380047891 0.0648890767657536 no 330 0.0799595348216975 521 5919439 SGTC_1313 1220-0047 237 µM 1.4023667865744 0.0652973565285559 no 331 0.0804028730679947 534 3528706 SGTC_1050 3232-1156 69.3 µM 1.39995908262081 0.0656290141817265 no 332 0.0807627858647341 488 700529 SGTC_2478 5763493 32.33 µM 1.39555435950814 0.0662391367751664 no 333 0.0814243672391819 486 1365576 YLR208W SEC13 SGTC_1548 st061468 90.8 µM 1.39500273852814 0.0663158533688766 no 334 0.0815075068742248 476 390799 SGTC_1107 amlodipine 47 µM 1.39355836716807 0.0665170550226739 no 335 0.0817255040003468 496 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.  SGTC_2906 7926292 26.41 µM 1.39242781547102 0.0666748708844142 no 336 0.0818964431529912 492 2966319 SGTC_1072 oxiconazole 14.9 nM 1.38626198328537 0.0675406757875888 no 337 0.082833460417801 525 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_2455 5377712 9.75 µM 1.38530644526844 0.0676756262586039 no 338 0.0829793918848753 442 2243908 SGTC_2758 dehydroepiandrosterone 69.35 µM 1.38448229857816 0.067792187584586 no 339 0.0831054122873594 529 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem] SGTC_2125 5246583 200 µM 1.38395428705312 0.0678669471602049 no 340 0.0831862262251095 564 835267 SGTC_2192 5915882 198.485 µM 1.38073403504093 0.068324272047605 no 341 0.0836803762033116 425 2876149 SGTC_2843 9000894 45.46 µM 1.38063962493831 0.0683377155148819 no 342 0.083694896704016 343 2242070 SGTC_941 3237-0776 460 µM 1.38008744881124 0.0684163831705609 no 343 0.083779860632657 465 760008 SGTC_923 1900-2434 73.3 µM 1.37833781963158 0.0686661115446704 no 344 0.0840495058226886 480 5910570 SGTC_2793 7325131 81.82 µM 1.37322936528356 0.0693992755765403 no 345 0.0848405266932354 451 4176441 SGTC_48 0382-0018 55 µM 1.37194120735396 0.0695851001581073 no 346 0.0850408704868934 464 762596 SGTC_2519 cryptotanshinone 88.04 µM 1.37066463948862 0.0697696305189994 no 347 0.0852397613152816 465 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE) SGTC_2564 betulinic acid 100 µM 1.36028206976367 0.0712844685730765 no 348 0.086870340077804 559 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14 SGTC_1741 st038134 10.228 µM 1.3545177149753 0.0721363313079325 no 349 0.0877856327798383 540 1272587 SGTC_3081 9117243 49.47 µM 1.35132815563826 0.0726110295839908 no 350 0.0882951683335133 479 45595589 SGTC_1552 6-methylflavone 10.6 µM 1.34672426108619 0.0733004358545375 no 351 0.0890345277822156 446 689013 SGTC_2989 9073649 71.4286 µM 1.34377186585279 0.0737451677929027 no 352 0.0895110849299304 614 21367202 SGTC_2801 7907800 81.82 µM 1.34204419095909 0.0740063697809304 no 353 0.0897908338178107 544 6620925 SGTC_301 4119-0100 24.5 µM 1.33861332774647 0.0745271665033682 no 354 0.0903482925289422 581 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1 SGTC_3069 9117009 49.47 µM 1.33837078187065 0.0745640899911855 no 355 0.0903877992910336 396 41904981 SGTC_1216 1165-0504 9.65 µM 1.3347829584703 0.0751119073254784 no 356 0.0909736963026932 537 6304004 SGTC_2523 spermine 47.74 µM 1.32523681570778 0.0765844325221607 no 357 0.0925463090559812 508 1103 A DNA binding polyamine. SGTC_1136 pergolide 1.05886 µM 1.32013315236518 0.0773806450831978 no 358 0.0933952828848937 617 47811 A dopamine receptor agonist. SGTC_1082 camptothecin 424.86 nM 1.32000292282748 0.0774010438930845 no 359 0.0934170210662402 470 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_1792 st045773 43.6 µM 1.31868117057994 0.0776083108101882 no 360 0.0936378621573556 519 2919270 SGTC_1169 aniline yellow 25.8 µM 1.31835890420748 0.0776589099590139 no 361 0.0936917654935887 492 6051 A DNA damaging agent. SGTC_474 dl-dihydrosphingosine 5 µM 1.31596168009061 0.0780360852671382 no 362 0.0940934523231691 543 3058739 A sphingolipid protein kinase C inhibitor. SGTC_183 3914-0051 30.55 µM 1.31301201027831 0.0785020866521026 no 363 0.094589450580177 530 1596232 SGTC_1503 4585-0012 61.3 µM 1.31191671781999 0.0786756616846995 no 364 0.0947741180673565 490 2922052 SGTC_2155 5570423 76 µM 1.30964886444884 0.0790359811181142 no 365 0.0951573248973521 516 797402 SGTC_2146 5545642 200 µM 1.30731265938532 0.0794084657936716 no 366 0.0955532732581482 541 825326 SGTC_1241 0364-0022 50.8 µM 1.30507484275463 0.0797665078622625 no 367 0.0959336820747268 574 4563895 SGTC_3225 9130819 49.47 µM 1.30274173797109 0.080141094482221 no 368 0.0963314737325523 544 4547121 SGTC_2747 doxorubicin 7.63 µM 1.30028095946805 0.0805376187159878 no 369 0.0967523457496073 356 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_1343 1487-0095 224 µM 1.298845440272 0.0807696184517354 no 370 0.0969984883741686 514 4560101 YGL055W OLE1 SGTC_1112 tnp00069 1.16933 µM 1.2984611589642 0.0808318091620594 no 371 0.0970644574531176 611 145826 SGTC_3090 9117696 49.47 µM 1.29674311140238 0.0811102940259043 no 372 0.0973597952238426 508 7923821 SGTC_935 2996-0153 430 µM 1.29411727362251 0.0815373241474561 no 373 0.0978124579200401 544 23738523 SGTC_398 bronopol 33.3 µM 1.29029662446225 0.0821616868848676 no 374 0.0984738442281831 551 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them. SGTC_396 dithiazanine 1.25 µM 1.2898302107294 0.0822381532611534 no 375 0.0985548080767512 520 10578 An antihelmenthic. SGTC_589 1227-0070 34.1 µM 1.28914083353077 0.0823512716073098 no 376 0.0986745649466532 551 2841384 SGTC_94 0334-0113 514.748 µM 1.28857860649353 0.0824436128807534 no 377 0.0987723124381141 542 6795178 SGTC_2647 atorvastatin 60.16 µM 1.27689535561091 0.0843801767322318 no 378 0.100819597026111 540 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7 SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM 1.27605619381431 0.0845205753904058 no 379 0.100967827721974 549 6710655 SGTC_1184 1269-1718 139 µM 1.27422122077985 0.0848281919118468 no 380 0.10129251329891 575 5403821 SGTC_564 3555-0129 330 µM 1.26714487983044 0.086022338938384 no 381 0.102551745286016 465 563260 SGTC_2378 9074213 121.43 µM 1.26684623519707 0.0860730110453593 no 382 0.102605138141633 589 657714 SGTC_1221 2958-7315 257 µM 1.26211549326187 0.0868786742631647 no 383 0.103453615520179 565 4562705 SGTC_2460 5552655 174.22 µM 1.25586616912603 0.0879515775809492 no 384 0.104582248086848 562 5401989 SGTC_128 0906-2981 13.371 µM 1.24997413673525 0.0889721603683259 no 385 0.105654497644867 521 6740226 SGTC_702 1488-0190 94 µM 1.24645610458144 0.0895857216969963 no 386 0.106298497387138 585 949357 SGTC_783 0848-0141 92.7 µM 1.24311788769037 0.0901708263789902 no 387 0.106912197545554 548 6755076 YHR007C | YLR033W ERG11 | RSC58 SGTC_775 4577-0580 57.3 µM 1.24280771711737 0.0902253352084347 no 388 0.106969349042692 594 2006902 SGTC_793 0488-0545 106 µM 1.23951576005358 0.090805367039979 no 389 0.107577277982184 599 292548 SGTC_3038 9091290 49.47 µM 1.23593323996228 0.091439734136356 no 390 0.108241690056063 597 25236843 SGTC_3350 9150499 3.57 µM 1.23370759378313 0.0918354864817645 no 391 0.108655941612763 656 4910996 YPR165W RHO1 SGTC_381 3461-2219 42.7 µM 1.23336649856468 0.0918962501332798 no 392 0.108719529075142 644 2883159 SGTC_1508 1080-0625 72.9 µM 1.2288685316646 0.0927003176988428 no 393 0.1095605508129 551 767111 SGTC_1530 rhein 70.4 µM 1.22847689203919 0.092770573640558 no 394 0.109633999369258 640 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death. SGTC_1036 k216-0215 33.5 µM 1.22790568869317 0.0928731119672563 no 395 0.109741186888805 631 622330 SGTC_71 0417-1750 47.813 µM 1.22502015443762 0.0933923834789667 no 396 0.110283813443325 635 6811472 SGTC_829 1635-0120 117 µM 1.22336109854849 0.0936919112598385 no 397 0.110596669798816 634 285054 SGTC_163 TUB2.036 7.546 µM 1.21824186543598 0.0946206133365674 no 398 0.111566037298972 780 15992207 YJR013W GPI14 SGTC_1546 5-methoxyflavanone 78.7 µM 1.21810579320568 0.0946453910330843 no 399 0.111591886341942 642 147795 SGTC_2133 5320837 200 µM 1.21679353657456 0.094884588272294 no 400 0.111841389908893 561 2841355 SGTC_2640 pentamidine 10.38 µM 1.21453357642002 0.0952975758176405 no 401 0.11227201811568 664 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_2430 5571206 200 µM 1.21427086261778 0.0953456701533477 no 402 0.112322154166573 678 1731771 SGTC_3177 9107506 49.47 µM 1.2130235796843 0.0955742508306432 no 403 0.112560402731712 555 8897194 SGTC_2379 9035213 200 µM 1.21213065678855 0.0957381379773214 no 404 0.112731185106307 660 646551 SGTC_1779 st039427 55 µM 1.21088732083208 0.0959666842070943 no 405 0.112969296312074 703 1124498 SGTC_930 2810-3379 265 µM 1.20877883190511 0.096355176924296 no 406 0.113373913068193 688 1015764 SGTC_1409 3909-8004 61.9 µM 1.20857693137085 0.0963924379931747 no 407 0.113412711721144 628 2119279 SGTC_394 menadione 8.33 µM 1.20702218989213 0.0966797228016691 no 408 0.11371179922417 642 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_3075 9116269 49.47 µM 1.20587214492197 0.096892632158316 no 409 0.113933396227768 624 17015205 YNL244C SUI1 SGTC_2356 9061756 188.97 µM 1.20425149991767 0.0971932484095131 no 410 0.114246193102744 573 20104043 SGTC_1291 0993-0025 5.79 µM 1.20029891963926 0.0979292884465919 no 411 0.115011634606482 628 4353356 SGTC_1433 4060-0023 7.6 µM 1.19961288685045 0.0980574547841132 no 412 0.115144859657913 638 3840627 SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM 1.19928634060657 0.0981185041151375 no 413 0.115208312269601 597 803109 SGTC_1657 st012939 43.4 µM 1.19925275698149 0.0981247843080757 no 414 0.115214839458372 572 24207257 SGTC_2669 eugenol 100 µM 1.19474315038905 0.0989707651414699 no 415 0.116093698903377 557 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism. SGTC_410 α-linolenic acid 100 µM 1.19459313613492 0.0989989985185259 no 416 0.11612301614511 662 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM 1.19429041007799 0.0990559909038743 no 417 0.116182193809962 606 756377 SGTC_2948 9070189 9.45 µM 1.19248825886495 0.0993957676364434 no 418 0.116534925901404 558 6473636 YDL196W YDL196W SGTC_1285 0929-0069 65.5 µM 1.19176838463886 0.099531730248546 no 419 0.116676037776885 632 1206237 SGTC_1064 honokiol 6.76 µM 1.19127714705058 0.0996245882603232 no 420 0.116772401143742 636 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis. SGTC_385 1494-0393 12.4 µM 1.18978333712705 0.0999073501451445 no 421 0.117065780208131 635 3090647 SGTC_2866 9034245 58.44 µM 1.18656941985326 0.100517695805298 no 422 0.117698752024625 594 6462273 SGTC_1637 st007924 17.4 µM 1.18642163089936 0.100545827253456 no 423 0.117727916778475 625 683336 SGTC_3125 9127534 49.47 µM 1.18530221270254 0.100759093684027 no 424 0.117948989477306 528 1639235 SGTC_1733 st037357 54.9 µM 1.17664704371365 0.102419181237133 no 425 0.119668206342113 636 1272339 YGL099W LSG1 SGTC_2947 9072639 7.68 µM 1.17510917711569 0.102716217716677 no 426 0.119975519795708 680 16488146 SGTC_981 1488-1094 54.9 µM 1.17401126649448 0.102928660109576 no 427 0.120195256459328 577 3449522 SGTC_1499 4480-0877 67.3 µM 1.17100493193759 0.10351201013617 no 428 0.120798397366938 595 2861909 SGTC_3155 9099265 49.47 µM 1.16906107361231 0.103890472066992 no 429 0.121189512907119 600 25236499 SGTC_1483 3453-0561 55.9 µM 1.16674398613236 0.104342910213607 no 430 0.121656886848376 690 4546991 SGTC_2898 9056270 58.44 µM 1.16619940325531 0.104449453252099 no 431 0.121766916897507 564 19154699 SGTC_2563 tomatine 8.54 µM 1.16578868165961 0.104529859589097 no 432 0.1218499472321 716 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties. SGTC_2305 7443522 69.23 µM 1.16247257617847 0.105180691517732 no 433 0.122521778953414 681 5415886 SGTC_784 4579-0127 173 µM 1.16238122565641 0.105198661740256 no 434 0.122540322972477 684 1948547 SGTC_3288 9119690 36.221 µM 1.16010277159337 0.105647591905275 no 435 0.123003482942461 579 17595618 YKL019W RAM2 SGTC_1222 0366-0074 1.18 µM 1.15653361933301 0.106353613705168 no 436 0.123731478183897 691 286520 SGTC_1616 st002734 56.1 µM 1.15443328348675 0.10677067487615 no 437 0.124161288103221 689 4026101 SGTC_2010 4012422 159 µM 1.15430724938591 0.106795738798232 no 438 0.124187112731547 673 952393 SGTC_1117 retinoic acid 1.10837 µM 1.15286705516404 0.107082446226611 no 439 0.124482478090871 724 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR). SGTC_2108 5365811 200 µM 1.15131802079146 0.10739144025107 no 440 0.124800713033037 663 780283 SGTC_3119 9125183 49.47 µM 1.1508859468482 0.107477742835499 no 441 0.124889579984098 516 22695334 SGTC_2887 9044784 58.44 µM 1.14988174406194 0.10767851567554 no 442 0.125096290479755 704 6465546 SGTC_2524 avocatin b 10.57 µM 1.14880591535412 0.107893908523591 no 443 0.125318009830748 600 6710748 SGTC_2856 9022925 19.48 µM 1.14356426254109 0.10894778485053 no 444 0.126402194847191 677 4944862 SGTC_3060 1327-0027 12.5 µM 1.14212604509335 0.109238239455396 no 445 0.126700815399795 638 16000455 YPR107C YTH1 SGTC_1946 st076057 65.1 µM 1.13998274265145 0.109672120885869 no 446 0.127146745438297 537 953009 SGTC_2722 naftopidil 47.16 µM 1.13762170087667 0.110151511172859 no 447 0.127639240540706 704 4418 An a1-adrenergic receptor antagonist or alpha blocker.  SGTC_2393 9031399 185.94 µM 1.1369039615106 0.110297539784248 no 448 0.127789217938704 667 1526623 YDL150W RPC53 SGTC_232 clozapine 119 µM 1.13614210423121 0.110452696302043 no 449 0.127948548080408 659 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM 1.13600591252478 0.110480448987165 no 450 0.127977044911464 717 676296 Flavone; oxidizing agent. SGTC_2518 prenyletin 46.28 µM 1.13558812534571 0.110565615433717 no 451 0.128064490451209 576 3873459 A coumarin with calcium channel inhibitory activity. SGTC_3151 9099821 49.47 µM 1.13368234691874 0.110954707728815 no 452 0.128463908567184 655 17174189 SGTC_1776 st049249 45.9 µM 1.12948040862897 0.111816057300502 no 453 0.129347614773191 683 1822314 SGTC_250 brefeldin a 552.239 µM 1.12888571139293 0.111938348745665 no 454 0.129473024564829 572 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.  SGTC_2122 5258151 111.688 µM 1.12762818539567 0.112197256826119 no 455 0.129738489082813 684 2173356 SGTC_1376 2910-0861 41.3 µM 1.12723684034194 0.112277916887046 no 456 0.129821179117413 696 1112859 SGTC_2556 citropten 84.59 µM 1.12715276996822 0.112295250023096 no 457 0.129838947695707 718 2775 A potential DNA crosslinker. SGTC_2692 st077426 47.7 µM 1.12503572157831 0.112732361134993 no 458 0.130286948720693 705 25238571 SGTC_1490 4089-0339 670 nM 1.12490070854852 0.112760278692703 no 459 0.130315555851488 653 742542 SGTC_1103 duloxetine 36.1 µM 1.12486794186941 0.112767054824984 no 460 0.130322499249019 762 60835 A selective serotonin reuptake inhibitor. SGTC_419 nsc-638432 893 µM 1.12252947010769 0.113251400598463 no 461 0.13081869228549 677 368090 SGTC_2292 7671323 168.05 µM 1.12090754756762 0.113588204708242 no 462 0.131163608926055 686 937504 SGTC_520 3584-0023 682 µM 1.1144668885476 0.114932701837052 no 463 0.132539470874119 654 1340790 SGTC_539 4859-0462 2.54 µM 1.11364353028051 0.115105391719331 no 464 0.132716071952272 704 46499474 YNL221C | YBR257W POP1 | POP4 SGTC_1532 4',5'-dihydroxyflavone 78.7 µM 1.11162489889728 0.115529556763614 no 465 0.133149731202141 730 165521 SGTC_211 3455-0679 143.504 µM 1.11127798802183 0.115602563116353 no 466 0.133224355578619 725 748649 SGTC_1426 4048-4480 71.7 µM 1.11083881760115 0.115695032213819 no 467 0.133318867277185 708 14224343 SGTC_974 1326-0144 138 µM 1.11074493397421 0.115714806603005 no 468 0.133339077492299 725 5411856 SGTC_2101 5377231 179.231 µM 1.10986246039375 0.115900796351667 no 469 0.1335291495356 693 2844213 SGTC_470 aa-861 153 µM 1.10941877816578 0.115994386770352 no 470 0.133624782628496 721 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor. SGTC_1172 0370-0043 85 µM 1.10682997429364 0.116541539441421 no 471 0.134183723077642 684 376585 SGTC_2052 5265182 7.135 µM 1.10412890198769 0.117114369064437 no 472 0.134768612766697 716 1239884 SGTC_92 0063-0024 660.874 µM 1.10266884622806 0.117424839511741 no 473 0.135085500277035 764 3594437 SGTC_1060 3448-7350 82 µM 1.10122176708654 0.117733125195136 no 474 0.135400075167952 714 570178 SGTC_1732 st034308 51.822 µM 1.09809754578057 0.118400661407072 no 475 0.13608094845571 668 830119 SGTC_330 1488-0319 80.1 µM 1.09722426814401 0.118587727631376 no 476 0.136271683501672 703 6846614 SGTC_2645 abamectin 100 µM 1.09601771463106 0.118846528893779 no 477 0.13653551111701 686 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels. SGTC_1059 3448-6867 171 µM 1.09504262556469 0.119055973163413 no 478 0.136748981289346 724 3934407 SGTC_2886 9058944 51.95 µM 1.09381335594299 0.119320385326137 no 479 0.137018422610474 545 4949929 SGTC_2754 granisetron 64.02 µM 1.09133562969289 0.119854595554262 no 480 0.137562612685876 714 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients. SGTC_2390 9097792 176.6 µM 1.09102380297805 0.119921946235187 no 481 0.137631204452897 672 4497149 SGTC_1713 st033146 12.748 µM 1.09086137458095 0.119957039309289 no 482 0.137666942678904 729 674619 SGTC_1590 st077108 57.8 µM 1.0887237510529 0.120419552993257 no 483 0.138137862372509 711 5489485 SGTC_85 0868-0259 160.055 µM 1.07847863457264 0.122653701751792 no 484 0.140410105731063 697 83173 SGTC_701 4424-0219 185 µM 1.07593050827559 0.123213857467061 no 485 0.14097916821883 799 2911779 SGTC_1736 st036774 51 µM 1.0759257832882 0.123214897825611 no 486 0.140980224881664 760 1272247 SGTC_466 geldanamycin 89.2 µM 1.07584695631337 0.123232255037555 no 487 0.140997853982354 599 5288382 HSP90 inhibitor. SGTC_506 n9-isopropylolomoucine 153 µM 1.07520120217375 0.123374510615313 no 488 0.141142328665566 735 6610355 SGTC_2218 6965428 192.983 µM 1.0741057288706 0.123616099546364 no 489 0.14138764860362 730 675684 SGTC_389 tpck 16.7 µM 1.07353058208837 0.12374307141148 no 490 0.141516562412785 721 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.  SGTC_590 k048-0076 22.4 µM 1.07260657746597 0.123947249753971 no 491 0.14172383617825 722 6832814 SGTC_2002 4023503 131 µM 1.07074674694089 0.124358933217141 no 492 0.142141658678191 844 4736863 YCR052W RSC6 SGTC_3294 9122953 26.2835 µM 1.07011459810371 0.124499080260621 no 493 0.142283864495398 735 16459826 SGTC_104 0074-0074 590.992 µM 1.06671054901056 0.125255654238077 no 494 0.143051281037207 599 3943124 SGTC_798 1287-0182 476 µM 1.0639680911488 0.125867515336357 no 495 0.143671577421353 807 1649755 SGTC_721 1187-1332 279 µM 1.0636940473903 0.125928770732317 no 496 0.143733660967187 659 25730 SGTC_2823 7987624 58.44 µM 1.0624698484092 0.126202662602694 no 497 0.144011219510289 742 2239440 SGTC_1201 1889-3372 45.9 µM 1.06233794706773 0.126232197846778 no 498 0.144041146617815 715 5392199 SGTC_3262 9137218 49.47 µM 1.06013260359763 0.126726730340199 no 499 0.144542138492156 590 17650664 SGTC_760 0568-0725 82.9 µM 1.06013169874961 0.126726933522384 no 500 0.144542344288771 788 3916171 SGTC_2583 asiatic acid 100 µM 1.05971886626843 0.126819658062163 no 501 0.14463625857912 721 5320556 A kinase inhibitor; arrests cells at G2/M. SGTC_1523 st012844 44.7 µM 1.05862814030944 0.127064868585694 no 502 0.144884582987276 738 4274103 SGTC_2847 9005661 71.43 µM 1.0565449047735 0.127534125662471 no 503 0.145359668289767 635 2991449 SGTC_2699 st077704 54.6 µM 1.05177664625266 0.128612726284132 no 504 0.146451018058555 744 645852 SGTC_1698 5-fluorocytosine 1.055 µM 1.04846775820606 0.129364921554604 no 505 0.147211574760899 759 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_270 tamoxifen 5.46 µM 1.04820410342515 0.129424987929069 no 506 0.147272290196227 816 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  YIL048W NEO1 SGTC_2988 9073640 71.4286 µM 1.04776169218206 0.129525822384174 no 507 0.147374208062296 711 9102229 SGTC_2017 5132927 60.65 µM 1.04588996249363 0.129953029525203 no 508 0.147805919576424 744 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis SGTC_3303 9125618 40.5795 µM 1.04541749676475 0.13006102000881 no 509 0.147915026769244 824 22695467 SGTC_2050 5263056 171 µM 1.04442893220531 0.130287174995182 no 510 0.14814349179979 830 763468 YGL055W OLE1 SGTC_1755 st041960 45.185 µM 1.04400120223654 0.13038511151857 no 511 0.148242416701785 752 2257073 SGTC_2840 9008771 71.43 µM 1.0422822553666 0.130779209011164 no 512 0.148640418387932 706 2992978 SGTC_1383 3049-0032 20.7 µM 1.03846625514742 0.131657031807584 no 513 0.149526518831186 772 712864 SGTC_2311 7694451 200 µM 1.0381913032562 0.131720437700797 no 514 0.149590500350538 751 2163142 SGTC_712 r015-0009 80.6 µM 1.03766501761555 0.131841861729968 no 515 0.149713018373204 707 6813872 YLR060W FRS1 SGTC_2708 st078559 56 µM 1.03656092347734 0.132096847947363 no 516 0.149970266297824 664 17250902 SGTC_2861 9024595 19.48 µM 1.03648411913169 0.132114598251766 no 517 0.149988172250705 679 16482810 SGTC_3045 9092950 49.47 µM 1.03454247560113 0.13256387918734 no 518 0.150441315209372 799 44120432 SGTC_2908 7930301 100 µM 1.03445817927928 0.132583408501762 no 519 0.150461009016658 844 2223178 SGTC_2099 5377090 177.372 µM 1.03341807625596 0.132824537037124 no 520 0.150704145389735 757 2243829 SGTC_1308 1187-1617 41.4 µM 1.03200321344398 0.133153031199069 no 521 0.151035306066889 795 2882570 SGTC_2700 st077718 96.8 µM 1.03120601687175 0.133338365465988 no 522 0.151222109838467 718 904970 SGTC_1574 spiramycin 23.7 µM 1.03111105619999 0.133360453985508 no 523 0.151244371819288 760 6419898 An antibiotic and protein synthesis inhibitor. SGTC_7 0192-1582 4.227 µM 1.02915760674931 0.133815398613108 no 524 0.151702809858235 870 252616 SGTC_1281 0884-0031 11.8 µM 1.02722123520747 0.134267417629588 no 525 0.152158150542115 799 1548255 SGTC_2186 6124449 200 µM 1.02579732628617 0.134600477726621 no 526 0.152493563321226 788 3834182 YLR033W RSC58 SGTC_1143 3454-2408 5.08 µM 1.02567159209688 0.134629914865829 no 527 0.152523204540812 740 X1143 SGTC_1413 3910-0535 34.4 µM 1.02562714345693 0.1346403223271 no 528 0.152533684004661 810 2876951 SGTC_2570 licareol 100 µM 1.02474644676967 0.134846647597889 no 529 0.152741420571272 748 443158 SGTC_746 1095-0025 46.6 µM 1.02334281442681 0.13517593180485 no 530 0.153072893603079 821 6749286 SGTC_2537 larixol 68.93 µM 1.02295814701743 0.135266268769088 no 531 0.153163817431271 833 6708759 SGTC_1829 berberine 14.4 µM 1.02253762058683 0.135365074364742 no 532 0.153263258200506 779 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_1796 st049173 110.4 µM 1.02233348215949 0.13541305593186 no 533 0.153311545692762 738 94134 SGTC_1654 st012436 41.8 µM 1.01788646093102 0.136461195967445 no 534 0.154365958265143 740 4323132 SGTC_2222 6885208 172.143 µM 1.01764241894853 0.136518875594503 no 535 0.1544239603821 758 609514 SGTC_2891 9063876 19.48 µM 1.01735945601659 0.136585775109275 no 536 0.154491230982321 726 6472478 SGTC_946 3434-1334 87.4 µM 1.01708664122909 0.136650296572878 no 537 0.154556107337636 755 4047976 SGTC_936 3005-4620 401 µM 1.0128858984333 0.137646415355241 no 538 0.155557332378203 849 777207 SGTC_2216 7189485 200 µM 1.01139916628158 0.138000147397025 no 539 0.155912710025682 819 731273 SGTC_782 0083-0095 30.5 µM 1.0113230657416 0.138018270349705 no 540 0.155930914932695 829 3591729 An indicator and reagent. SGTC_3188 9110789 49.47 µM 1.00955334654848 0.13844017770966 no 541 0.156354665480032 790 849217 SGTC_1556 plumbagin 1.48 µM 1.00507738965569 0.139511181330337 no 542 0.157429793253229 739 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_956 1185-0240 191 µM 1.00181116932991 0.140296267581458 no 543 0.158217400848693 765 1416193 SGTC_2243 6634756 200 µM 0.999668811374548 0.140812842650706 no 544 0.158735405153499 768 885676 SGTC_2358 9037157 4 µM 0.999353038690398 0.140889092178719 no 545 0.158811850267778 795 2388925 SGTC_830 4076-0286 57.8 µM 0.998927536157549 0.140991882431269 no 546 0.158914897939195 933 6866659 SGTC_1434 4073-0095 163 µM 0.998003150548266 0.141215364996649 no 547 0.159138915457697 840 24133745 SGTC_3157 9099274 49.47 µM 0.995348616108795 0.141858468670875 no 548 0.159783370215513 789 17217662 SGTC_1012 4112-3522 18 µM 0.994582537641993 0.142044431683876 no 549 0.159969671992997 824 3112398 SGTC_1656 st012921 11 µM 0.992226497326061 0.142617386483112 no 550 0.160543524755861 755 6732821 SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM 0.9858295342804 0.144180907944499 no 551 0.162108385087718 845 16623 A steroid. SGTC_2531 methyl deoxycholate 70.07 µM 0.982810193242468 0.144922883557661 no 552 0.162850432059223 765 16667744 Haematoxylin. SGTC_1411 3909-8223 150 µM 0.981892693117821 0.145148859248017 no 553 0.163076357944083 875 X1411 SGTC_1939 st074455 53.6 µM 0.98179792174249 0.145172214468048 no 554 0.163099706118056 831 1644229 SGTC_826 1683-5028 118 µM 0.981353297228387 0.145281820380152 no 555 0.163209274217137 811 722377 SGTC_3244 9134489 49.47 µM 0.979969023834603 0.145623418784992 no 556 0.163550704655335 799 16584271 SGTC_2526 patulin 37.61 µM 0.977999369539239 0.146110402352334 no 557 0.164037317950785 856 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.  SGTC_2396 5342950 42.78 µM 0.976955807201098 0.146368858850942 no 558 0.164295515687075 829 1886677 SGTC_435 c-PAF 6.7 µM 0.97670687523399 0.146430556531395 no 559 0.164357145231124 844 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase SGTC_2055 5235184 200 µM 0.976045335386243 0.146594603737559 no 560 0.164520999353887 798 2836034 SGTC_319 1348-1596 45.5 µM 0.975707365441992 0.146678460370644 no 561 0.164604750605072 858 5380505 SGTC_2851 9015922 71.43 µM 0.973273524262493 0.147283292072802 no 562 0.165208688676184 816 2996893 SGTC_56 0957-0365 83.25 µM 0.972046440392563 0.147588866557275 no 563 0.165513722765565 827 6752360 SGTC_708 3448-5400 146 µM 0.970898326471488 0.147875159854958 no 564 0.165799455812946 822 3462195 SGTC_3202 9113761 49.47 µM 0.970623166557423 0.147943828832354 no 565 0.165867982666249 899 4798415 SGTC_3018 9082602 49.47 µM 0.970513165766893 0.147971286628804 no 566 0.165895382795665 862 17332089 SGTC_1093 fluphenazine 7.97 µM 0.967499427348747 0.148724886550833 no 567 0.166647213693528 852 6602611 An atypical antipsychotic. SGTC_2941 9056145 11.23 µM 0.965522046649649 0.149220731575901 no 568 0.167141699437943 763 2119517 SGTC_1099 5-nonyloxytryptamine 2.85 µM 0.963787418843684 0.149656612191197 no 569 0.167576257788689 792 23581825 A 5-HT1D beta serotonin receptor agonist. SGTC_2143 5623677 140.463 µM 0.962828176870902 0.149898016782673 no 570 0.167816878977978 818 5375313 SGTC_1688 st021091 57.6 µM 0.958591484784847 0.150967335516153 no 571 0.168882291976496 866 3656366 SGTC_1646 st011709 75.6 µM 0.956545918599381 0.151485438569086 no 572 0.169398248464602 810 5757843 SGTC_2982 9019404 25.97 µM 0.952964332158598 0.152395430263517 no 573 0.170304071413158 723 22333232 SGTC_2616 abietic acid 100 µM 0.949157020825772 0.153366743356744 no 574 0.171270378555125 905 6708678 Abietic acid is an inhibitor of 5α-reductase. SGTC_3043 9092303 49.47 µM 0.948557006398782 0.153520191023429 no 575 0.171422983168326 802 25236084 SGTC_951 1171-0579 82.7 µM 0.946137073715433 0.154140096185158 no 576 0.172039338254833 906 1616050 YPR165W | YDR526C RHO1 | YDR526C SGTC_3089 9117425 49.47 µM 0.944910480966263 0.154454939348212 no 577 0.172352290101829 784 9401657 SGTC_739 1486-1183 203 µM 0.944576618114145 0.15454070918289 no 578 0.172437534428561 890 4346692 SGTC_1115 galangin 695.678 nM 0.944031122557735 0.154680915482026 no 579 0.172576872231942 939 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_1317 1273-0028 910 nM 0.943989714893986 0.154691561741096 no 580 0.172587452064604 875 5917803 YLR359W | YHR072W ADE13 | ERG7 SGTC_3124 9127567 49.47 µM 0.94148289883817 0.155336987203463 no 581 0.173228724439665 830 17592030 SGTC_1504 k297-0033 30 µM 0.941349670221045 0.155371339001936 no 582 0.173262848261729 725 4388117 SGTC_528 3492-0019 172 µM 0.941120111595626 0.1554305403846 no 583 0.173321655112154 1012 2869262 SGTC_561 1550-0330 72.9 µM 0.940125891256035 0.155687113876343 no 584 0.173576494755658 813 6812934 SGTC_135 0933-0004 26.348 µM 0.93634178870217 0.156666211707523 no 585 0.174548619425998 814 21230617 YGL099W LSG1 SGTC_2048 5246248 200 µM 0.935437505694457 0.156900784393845 no 586 0.174781437911953 865 677046 SGTC_1446 4239-0190 62 µM 0.934801165574984 0.157065990646963 no 587 0.174945389399788 890 1340085 SGTC_621 3584-0052 32.1 µM 0.934774157975308 0.157073004874409 no 588 0.174952350000476 905 2273927 SGTC_38 0929-0051 58.268 µM 0.934324882382202 0.157189717850962 no 589 0.175068166444122 915 1379719 SGTC_3277 9138724 49.47 µM 0.934212231605337 0.157218991250315 no 590 0.175097213733252 769 15943418 SGTC_1868 st057644 42.7 µM 0.933188189492868 0.157485262935799 no 591 0.175361405796203 934 688665 SGTC_2507 purpurin 79.67 µM 0.931203043674936 0.158002284687113 no 592 0.175874271877933 875 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1 SGTC_2736 butenafine 14.65 µM 0.924079872076337 0.159866643647791 no 593 0.177722366011883 906 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_1177 0983-0204 23.6 µM 0.923080831721064 0.160129270039003 no 594 0.177982541485259 932 766818 SGTC_1515 3460-0031 42.1 µM 0.921587615269449 0.160522330341921 no 595 0.178371860465289 827 2876596 SGTC_3217 9129673 49.47 µM 0.921100084816275 0.160650799662971 no 596 0.178499087984923 831 17248312 SGTC_206 4546-0025 72.014 µM 0.919615919242643 0.161042305906865 no 597 0.178886752384906 928 6620745 YIL048W NEO1 SGTC_2438 5259590 200 µM 0.919042782729525 0.161193659405826 no 598 0.179036597496017 937 1201127 SGTC_2288 7946289 167.31 µM 0.914098308159654 0.162503245281551 no 599 0.180332595718158 969 1246052 SGTC_2283 7944793 200 µM 0.913523185478015 0.162656019617127 no 600 0.180483722606099 900 2970533 SGTC_612 0302-0167 22.4 µM 0.913438895392087 0.162678418099552 no 601 0.180505878463734 966 235821 SGTC_847 0342-0274 5.54 µM 0.912731520182178 0.162866468634552 no 602 0.180691881016319 931 18097 SGTC_1923 st058458 19.1 µM 0.910839824713023 0.163370056220112 no 603 0.181189887783156 959 3534982 SGTC_794 k038-0031 316 µM 0.910376929477905 0.163493437273025 no 604 0.18131188014214 948 6624242 SGTC_2750 bromebric acid 70.15 µM 0.907427968705497 0.164280879728514 no 605 0.182090262354859 946 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2 SGTC_516 3992-2719 87.3 µM 0.906351712892782 0.164568877072889 no 606 0.182374861113301 896 5350887 YDR037W KRS1 SGTC_1086 cerivastatin 2.18 µM 0.906160689301673 0.164620027608997 no 607 0.182425403294029 891 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7 SGTC_884 0851-0618 334 µM 0.905867697038903 0.164698502392038 no 608 0.182502941966287 928 9642473 SGTC_1981 st071826 47 µM 0.904756318237488 0.164996393376919 no 609 0.182797248904074 844 11838600 SGTC_1847 st056231 15 µM 0.902296387571286 0.165656986430278 no 610 0.183449722015206 960 5393180 SGTC_182 3448-4371 550.524 µM 0.898477564660747 0.166685881646951 no 611 0.184465500435306 981 3491403 SGTC_1557 sumaresinolic acid 42.3 µM 0.896844003388628 0.167127264288868 no 612 0.184901081858498 857 9982268 A natural terpine and antifungal of unknown mechanisn. SGTC_1261 0712-0010 12.7 µM 0.895526006570285 0.167483931248029 no 613 0.18525298500017 949 2840123 SGTC_543 3844-1095 191 µM 0.890148116601461 0.168944336175224 no 614 0.186693179697929 932 4230703 SGTC_2574 2',4'-dihydroxychalcone 14.64 µM 0.886299644590572 0.169994422668728 no 615 0.187728040259737 982 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_713 1488-1073 324 µM 0.882691737536169 0.170982660349673 no 616 0.188701423768008 946 3312542 SGTC_3176 9106582 49.47 µM 0.880040099773378 0.171711305728461 no 617 0.189418793384468 824 17018027 SGTC_390 dec-rvkr-cmk 16.7 µM 0.879868497609921 0.171758528642007 no 618 0.189465276097334 965 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1 SGTC_101 0490-5701 117.494 µM 0.879827489912354 0.171769814709848 no 619 0.189476385090944 874 4661669 SGTC_360 0957-0399 1.01 µM 0.877862536963496 0.172311160724788 no 620 0.190009160908522 956 6752301 YPR165W RHO1 SGTC_1209 2323-2347 50.3 µM 0.875528320957622 0.172955651878471 no 621 0.190643253719164 956 5412760 SGTC_422 cantharidin 155 µM 0.871905733008605 0.173958907493336 no 622 0.191629902931442 911 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_1973 st070275 50.2 µM 0.871164862765698 0.17416454225871 no 623 0.191832071141257 933 17118334 SGTC_1604 st002052 72.4 µM 0.870418292560321 0.174371915310621 no 624 0.192035926788931 931 6254834 YHR062C RPP1 SGTC_1340 1486-1359 257 µM 0.870401132487127 0.174376683667316 no 625 0.192040614011913 960 4309068 SGTC_202 3594-0513 34.79 µM 0.869713048541004 0.174567953302635 no 626 0.192228619778713 933 708429 SGTC_639 0833-0042 114 µM 0.868407719078465 0.174931167265772 no 627 0.192585585309134 967 5978911 YPR085C | YHR062C ASA1 | RPP1 SGTC_3064 1327-0027 10 µM 0.867633099180751 0.175146935401372 no 628 0.19279761031073 823 16000455 YPR107C YTH1 SGTC_2341 7987486 176.74 µM 0.867373750637723 0.175219213893529 no 629 0.192868629723076 984 1258686 SGTC_1251 0490-5699 265 µM 0.866872506777653 0.175358960395354 no 630 0.193005934476562 1027 3883818 SGTC_1245 0418-0076 17.2 µM 0.865658524921111 0.175697710567983 no 631 0.193338725423482 934 6790114 SGTC_824 1304-0008 100 µM 0.86191143205933 0.176745914056653 no 632 0.19436812878754 952 768245 SGTC_751 0833-0568 350 µM 0.860305079993589 0.177196479611497 no 633 0.194810446669794 948 6954252 SGTC_1964 st076914 61 µM 0.85898228109011 0.17756805553243 no 634 0.195175145894213 1009 24208661 SGTC_1909 st060837 51.5 µM 0.858356336492716 0.177744055456839 no 635 0.195347865039249 901 678937 SGTC_1846 st056244 14.8 µM 0.857747350045922 0.177915392758847 no 636 0.195515993946873 973 5393182 SGTC_1997 st073024 93.8 µM 0.857702395647489 0.177928044729396 no 637 0.195528408433857 975 686268 SGTC_970 1315-0089 19.5 µM 0.855897398419375 0.178436512033469 no 638 0.196027267056383 934 6811083 YLR033W RSC58 SGTC_666 0272-0154 136 µM 0.853971328851847 0.178980093860674 no 639 0.196560437819563 964 6870312 SGTC_3080 9117754 49.47 µM 0.852814464508801 0.179307088359937 no 640 0.196881100652052 1018 9550191 SGTC_25 0118-0223 35.662 µM 0.851325217467196 0.179728585476093 no 641 0.197294360209735 964 5333628 SGTC_1735 st034310 56.75 µM 0.850921689325813 0.179842901936649 no 642 0.197406427794752 943 871153 SGTC_1753 st043925 64 µM 0.850105710020992 0.180074202196344 no 643 0.197633158654767 1001 670181 SGTC_1258 0671-0043 57.1 µM 0.848135537041399 0.180633443548271 no 644 0.19818124625565 971 4298767 SGTC_2281 7943571 200 µM 0.845680357665243 0.181331878343875 no 645 0.198865541838767 1061 1244024 SGTC_3309 9129340 25.759 µM 0.844037894075821 0.181800059292628 no 646 0.199324115321104 1020 17158987 SGTC_258 haloperidol 50.781 µM 0.844010099538839 0.18180798857034 no 647 0.199331880990837 948 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_542 3381-0244 89.3 µM 0.843360940998045 0.18199324326423 no 648 0.199513304804253 1029 1112843 SGTC_2332 7982454 138.89 µM 0.842528960058725 0.182230843712937 no 649 0.199745968232369 981 2981748 SGTC_1217 1183-1422 255 µM 0.839950443849353 0.182968457443912 no 650 0.200468086309729 1033 2849664 SGTC_671 0560-0003 407 µM 0.837487459812362 0.183674758964147 no 651 0.201159311436166 956 3238678 SGTC_1218 1348-1416 30.7 µM 0.836145879133676 0.184060193172029 no 652 0.201536420403563 1013 6787668 SGTC_468 gf-109203x 121 µM 0.835287202435731 0.184307153843025 no 653 0.201778010595787 903 2396 A protein kinase C inhibitor. SGTC_2499 avocadenofuran 51.48 µM 0.834970212356166 0.184398374210988 no 654 0.201867240119237 985 6857792 A insecticide and lysyl oxidase inhibitor. SGTC_1722 st034304 3.6505 µM 0.833538214033435 0.184810810913207 no 655 0.202270627592016 989 4036148 YLR033W RSC58 SGTC_1925 st057770 10.1 µM 0.832936575803563 0.184984262546926 no 656 0.20244025011271 920 5989122 SGTC_913 3487-1245 167 µM 0.832916276432919 0.184990116596346 no 657 0.202445974686697 956 4016153 SGTC_861 0443-0273 110 µM 0.829064623723419 0.186102960690879 no 658 0.203533920173168 1018 6149169 SGTC_1600 coumarin 106 71.1 µM 0.82877679707004 0.18618628770759 no 659 0.203615360054411 1015 100336 A hepatotoxic, DNA x-linker. SGTC_2715 st079500 56.4 µM 0.826971687232556 0.186709401606259 no 660 0.204126554615944 953 28246688 SGTC_1851 st056236 18.9 µM 0.826716527767049 0.186783419165895 no 661 0.204198875618699 1048 5393171 SGTC_2338 7999974 200 µM 0.825098310050691 0.187253260200626 no 662 0.204657889543708 1075 315925 SGTC_2033 5192550 145 µM 0.822242785969631 0.188084127276035 no 663 0.20546936605603 1006 182073 SGTC_1432 4049-0298 68.4 µM 0.822123666541399 0.188118836626815 no 664 0.20550325861281 1014 741646 SGTC_953 1188-0045 9.7 µM 0.821606319763734 0.188269628435216 no 665 0.20565049565636 1022 6144426 SGTC_2229 7354935 190 µM 0.820877099519015 0.188482301906475 no 666 0.205858138247958 984 318112 SGTC_2642 cholecalciferol 100 µM 0.820659877339639 0.188545682307264 no 667 0.205920015443774 1008 9821465 A vitamin D precursor, similar to steriods. SGTC_2628 lathosterol 100 µM 0.820619848322546 0.188557363281143 no 668 0.205931419181735 1034 6710616 SGTC_1404 3909-7820 48.3 µM 0.820389162633342 0.188624688980402 no 669 0.205997145785766 1018 23741373 SGTC_105 0111-0055 734.78 µM 0.820188571928453 0.188683243492485 no 670 0.206054307885761 901 5179370 SGTC_3025 9087895 49.47 µM 0.817454925691864 0.18948233969184 no 671 0.2068342490223 1064 17173641 SGTC_2303 7774051 200 µM 0.816700890437569 0.189703124291951 no 672 0.207049691172352 979 2953184 SGTC_2997 9067075 71.4286 µM 0.812963251795536 0.190799854495518 no 673 0.208119563853716 1018 27209819 SGTC_1178 0988-0033 191 µM 0.812593788296722 0.190908476561437 no 674 0.208225497079873 1029 5392207 SGTC_834 0312-0008 75.7 µM 0.811855825728422 0.191125550680938 no 675 0.208437182222278 1016 6385573 YIL048W NEO1 SGTC_648 0375-0473 33.3 µM 0.810292568290887 0.191585887617981 no 676 0.20888602280703 1030 1713139 SGTC_814 3342-0569 96 µM 0.810099061342144 0.191642917369469 no 677 0.208941621865088 1018 4346283 SGTC_169 k015-0017 16.025 µM 0.80996045354969 0.191683773806999 no 678 0.208981452473422 992 1840002 SGTC_2644 guaiazulene 100 µM 0.808652400450268 0.192069602008583 no 679 0.209357557384347 1043 3515 A coloring agent. SGTC_1389 3405-0187 19 µM 0.807890932631948 0.192294426067253 no 680 0.20957668577692 974 799890 SGTC_1700 st030840 7.9285 µM 0.807204380823057 0.192497269024196 no 681 0.209774371110371 1039 5499307 SGTC_3301 9125354 19.7965 µM 0.807196673852887 0.19249954680447 no 682 0.20977659087298 959 41905162 SGTC_2964 9083345 53.42 µM 0.806508702384318 0.192702941832657 no 683 0.209974796140181 985 17741579 SGTC_2346 9031566 143.75 µM 0.805822905636689 0.192905824561804 no 684 0.210172484352778 1026 4771086 SGTC_2739 tacrine 100.86 µM 0.805519283725409 0.192995688222152 no 685 0.210260041502821 1033 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders. SGTC_3180 9109287 49.47 µM 0.803035740412026 0.193731707501607 no 686 0.210977038600472 982 18891271 SGTC_2933 9026794 32.47 µM 0.802631200464003 0.193851758246861 no 687 0.211093964589752 1006 17586027 SGTC_1079 idarubicin 2.36 µM 0.800768167115835 0.194405214608127 no 688 0.211632935443261 1011 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_3072 9116419 49.47 µM 0.800185973173451 0.194578365620937 no 689 0.211801527733831 1016 17170162 SGTC_273 hydroxyurea 18.1 mM 0.799893617297748 0.194665350925435 no 690 0.211886218064986 1103 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12 SGTC_2772 vinpocetine 57.06 µM 0.799822607751498 0.194686482126887 no 691 0.211906791265623 1012 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor. SGTC_3240 9133527 49.47 µM 0.798911087140691 0.194957858669177 no 692 0.212170984816484 1002 17617455 SGTC_918 glabranin 770.725 nM 0.798463545367414 0.195091184277237 no 693 0.212300769997596 1036 124049 Also referred to as licorice root. SGTC_2066 5222451 176 µM 0.798447341050384 0.195096012688237 no 694 0.21230547004977 1099 2281147 SGTC_566 0958-0068 16.5 µM 0.796781129195694 0.195592882595241 no 695 0.212789078295344 1001 6815365 SGTC_2611 pyromycin 23.93 µM 0.796382067435102 0.195711998086265 no 696 0.212904999018494 1029 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release. SGTC_3284 9108171 64.8615 µM 0.794773248697737 0.196192658998606 no 697 0.21337270741035 977 8687505 SGTC_21 0849-0113 22.993 µM 0.793621299982824 0.196537261882623 no 698 0.213707964313518 1049 1560156 SGTC_597 k018-0003 82.8 µM 0.791932912482946 0.1970430014219 no 699 0.214199897478108 1130 6786234 SGTC_3218 9131285 49.47 µM 0.791720381946756 0.197106718578735 no 700 0.214261867603737 1071 17156417 SGTC_37 0566-0070 1.56 µM 0.791071030303658 0.197301472965995 no 701 0.214451271598333 1087 1626686 SGTC_444 curcumin 90.4 µM 0.789371555405844 0.19781173236031 no 702 0.214947437909081 1010 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. SGTC_2352 9027995 87.8 µM 0.788588444776107 0.198047125768351 no 703 0.215176293389043 994 2997347 SGTC_347 4534-1311 26.2 µM 0.786951776217869 0.198539634054684 no 704 0.21565504822364 1071 2862016 SGTC_3211 9128781 49.47 µM 0.786866910505711 0.198565192079278 no 705 0.21567988979364 944 17194361 SGTC_3065 9113888 49.47 µM 0.78584130870213 0.198874217589429 no 706 0.215980231215963 1020 16648368 SGTC_697 0508-1955 564 µM 0.785305933267539 0.199035647403381 no 707 0.216137108952362 1081 6243113 SGTC_2782 7736369 71.43 µM 0.782409139682848 0.199910475591439 no 708 0.216987082099233 1098 2950836 YOL077C BRX1 SGTC_647 0140-0236 81 µM 0.781909878003455 0.200061485289083 no 709 0.217133769688187 1113 990837 SGTC_2408 sulbentine 18.36 µM 0.781414902376285 0.200211266275021 no 710 0.217279254535647 1015 67686 An antifungal agent of unknown mechanism. YDL205C HEM3 SGTC_3120 9124077 49.47 µM 0.780909217375584 0.200364357518121 no 711 0.21742794523839 1154 18774327 YGL155W CDC43 SGTC_2085 5307070 144.047 µM 0.778683801357273 0.201038915980385 no 712 0.218083000263269 1015 2840351 SGTC_1069 diphenylcyclopropenone 8.49 µM 0.777929054527828 0.201268000553102 no 713 0.218305419349333 1155 65057 A dermal irritant. YDR527W RBA50 SGTC_3344 9148862 3.898 µM 0.774826594243914 0.202211317587254 no 714 0.219221066203601 1089 4905352 SGTC_3028 9087778 49.47 µM 0.774795201240926 0.202220876268602 no 715 0.219230342668498 1077 17217395 SGTC_164 4100-3994 89.624 µM 0.773917767759213 0.202488150468104 no 716 0.219489710854437 1112 4615967 SGTC_354 2783-3500 4.88 µM 0.773741857929471 0.202541759602388 no 717 0.219541730773773 1048 6740761 SGTC_1685 st024049 53.0905 µM 0.77347558767929 0.202622922529521 no 718 0.219620485477734 1046 1941139 SGTC_916 4466-0038 42 nM 0.773324761230369 0.202668905180865 no 719 0.219665102586158 1144 5722064 YGL116W CDC20 SGTC_511 blebbistatin 171 µM 0.772658106861085 0.202872223634223 no 720 0.219862372972149 1076 3476986 A myosin inhibitor. SGTC_887 0885-0007 9.62 µM 0.771690730139791 0.203167473967204 no 721 0.220148811165163 1084 5719458 SGTC_1651 st011928 86.1 µM 0.769266452527766 0.203908506893816 no 722 0.220867574111668 1063 720198 SGTC_1799 st045822 46.1415 µM 0.769033448979744 0.203979814217261 no 723 0.220936726965229 1086 3674992 SGTC_2679 rapamycin 1 nM 0.76855427433549 0.204126505288283 no 724 0.221078979599974 1124 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2 SGTC_2015 5119600 184 µM 0.768401491947189 0.204173290195251 no 725 0.221124347143462 1081 2828786 SGTC_2261 9010538 184.68 µM 0.763551743824496 0.205661692712807 no 726 0.222567207846645 1024 6457250 SGTC_1760 st045453 10.4495 µM 0.763432517479127 0.205698364566244 no 727 0.222602746648094 1110 3323419 YIL048W NEO1 SGTC_2278 7948257 134.34 µM 0.763328095815143 0.205730485956919 no 728 0.222633875150753 1081 1247028 SGTC_1244 0416-0015 52.5 µM 0.762977007114544 0.205838506995385 no 729 0.222738554248246 1080 96201 SGTC_3111 9122088 49.47 µM 0.762918952516343 0.205856372156216 no 730 0.222755866259848 1011 16876704 SGTC_359 0081-0058 15.9 µM 0.757441627698068 0.207546045474034 no 731 0.224392662325128 1077 3494159 SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM 0.756670625054123 0.20778454464328 no 732 0.224623608868503 1105 7104 SGTC_584 0986-0246 15.4 µM 0.75634241293349 0.207886121696242 no 733 0.224721962603121 1206 53315 YDR232W HEM1 SGTC_1019 4262-0212 3.4 µM 0.755538071371794 0.208135178089689 no 734 0.224963098976317 1195 4677213 SGTC_1622 st003707 19.4 µM 0.75532380979379 0.208201551753683 no 735 0.225027357932422 1109 10140899 SGTC_821 1114-0266 29.2 µM 0.754767761062908 0.208373862037978 no 736 0.225194170415895 1073 3123235 SGTC_3131 9127911 49.47 µM 0.753607707901766 0.208733613958066 no 737 0.225542407312246 1106 45595681 SGTC_2491 paeonol 100 µM 0.753007791964185 0.208919801447066 no 738 0.225722615849143 1086 11092 Increases levels of cortical cytochrome oxidase. SGTC_872 0588-0139 234 µM 0.751722131627143 0.209319143139474 no 739 0.226109089103232 1147 2047100 SGTC_423 5-fluorouracil 457 µM 0.750751262277673 0.209621004432056 no 740 0.226401182928172 1081 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_1368 1852-0141 284 µM 0.749052583664062 0.210149770539946 no 741 0.226912756243364 1087 2838987 SGTC_3340 9146634 11.102 µM 0.748261348162895 0.210396334215149 no 742 0.227151266777671 1118 4907387 SGTC_430 0958-0115 16.4 µM 0.74620832755664 0.211036885031703 no 743 0.227770789198291 1032 6833180 SGTC_2571 chrysanthemic acid 100 µM 0.746005728821078 0.211100158575691 no 744 0.227831977190713 1064 2743 An insecticide. SGTC_1353 1498-1206 8.11 µM 0.744274284312398 0.211641358816722 no 745 0.228355277713163 1161 6756808 SGTC_1173 0443-0020 122 µM 0.743521088913543 0.211877039509784 no 746 0.22858312924943 1120 5331295 SGTC_2213 7173844 200 µM 0.741780082240508 0.212422401293156 no 747 0.229110295116166 1129 892728 SGTC_2374 9071832 200 µM 0.740884066110602 0.212703393311165 no 748 0.229381868731204 1096 17381698 SGTC_822 1487-0950 154 µM 0.740837572151775 0.212717979807657 no 749 0.229395965512248 1128 1958375 SGTC_317 4495-0002 170 µM 0.739696828854807 0.21307604681136 no 750 0.229741986358325 1078 15991618 SGTC_1280 0880-0253 10.1 µM 0.739470879974037 0.213147011422121 no 751 0.229810557934636 1104 6836607 SGTC_462 ag-879 158 µM 0.737710601802153 0.213700340428963 no 752 0.230345164131167 1156 6809654 Ag-879 is a 5-Lipoxygenase inhibitor. SGTC_1497 4476-2978 41.3 µM 0.736303686586369 0.214143193712478 no 753 0.230772951581245 1170 1528379 SGTC_500 h-89 112 µM 0.736135453292844 0.214196184058869 no 754 0.230824134379639 1152 449241 Protein kinase A inhibitor; also known to inhibit several other kinases. SGTC_76 0433-0009 400.328 µM 0.735185628792477 0.214495504138359 no 755 0.231113225075329 1028 2841569 SGTC_2280 7785178 200 µM 0.734985642099381 0.214558557319543 no 756 0.231174119209444 1109 2954328 SGTC_1934 st074720 32.6 µM 0.733976708228227 0.214876825191965 no 757 0.231481466893504 1175 17250992 SGTC_1521 st012942 49.4 µM 0.733752516507668 0.214947583620276 no 758 0.231549792486603 1170 24207259 SGTC_1415 3966-0071 78.1 µM 0.732951452471596 0.215200522548063 no 759 0.231794019891096 1128 2893185 SGTC_1390 3413-2614 145 µM 0.732476478730077 0.215350578811251 no 760 0.231938897035926 1182 3421432 SGTC_3137 9097352 49.47 µM 0.731816197196012 0.215559279335733 no 761 0.232140380767012 1230 44120435 SGTC_3299 9121982 43.1275 µM 0.731159571609597 0.215766940569696 no 762 0.232340845466387 1171 17594604 YPL160W CDC60 SGTC_3278 9139605 49.47 µM 0.729672416583541 0.216237689514378 no 763 0.232795222742162 1162 7958859 SGTC_2306 7482397 179.52 µM 0.729257874576063 0.216369015909644 no 764 0.232921967600785 1126 891448 SGTC_675 1309-0189 238 µM 0.729141620372594 0.216405853384309 no 765 0.232957518822913 1131 4246530 SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM 0.728971627132043 0.216459725683917 no 766 0.233009509185196 1114 4620898 SGTC_1254 0550-0035 264 µM 0.72848696159698 0.216613362900798 no 767 0.233157773605687 1164 15121435 SGTC_685 1278-0033 54.9 µM 0.727906841397532 0.216797341813001 no 768 0.233335307477714 1160 3590572 SGTC_1610 st001799 48.1 µM 0.72743132734365 0.216948213365404 no 769 0.233480884709982 1051 621897 SGTC_1398 3558-0053 112 µM 0.726556597058365 0.217225907062648 no 770 0.233748812347469 1076 4532369 SGTC_3086 9117350 49.47 µM 0.725756644664148 0.217480041255012 no 771 0.233993984825262 1096 2679265 SGTC_2525 harmine 47.85 µM 0.725238319234657 0.217644797911129 no 772 0.234152919211295 1101 5280953 A monoamine oxidase inhibitor SGTC_2426 5582046 32.21 µM 0.723898365360725 0.218071053736466 no 773 0.234564066805428 1153 2251934 SGTC_1813 st051246 8.6015 µM 0.722621122985454 0.218477807861381 no 774 0.23495634361763 1114 5291959 SGTC_2806 7952793 58.44 µM 0.721334247000006 0.218888071446816 no 775 0.235351945512063 1145 2972490 SGTC_203 k066-0004 30.888 µM 0.719577295455596 0.219448912865279 no 776 0.23589264770656 1247 6795412 SGTC_2063 5246145 200 µM 0.719446065193398 0.219490836353527 no 777 0.235933061309886 1187 711240 SGTC_2547 epiafzelechin trimethyl ether 100 µM 0.718920720651252 0.219658711666181 no 778 0.236094884351586 1030 6708630 An antioxidant. SGTC_3264 9137442 49.47 µM 0.718886221003786 0.219669738703972 no 779 0.236105513493565 1157 17015726 SGTC_2834 9001755 58.44 µM 0.718389876017193 0.21982841941488 no 780 0.236258463691068 1063 2989575 SGTC_2121 5257820 149.641 µM 0.718190558357924 0.219892159467249 no 781 0.236319899377447 1207 791256 SGTC_2626 ethyl orsellinate 100 µM 0.717425516481631 0.220136911663581 no 782 0.236555789906688 1166 75653 A natural product. SGTC_2691 st077356 60.2 µM 0.717066850151797 0.220251709971569 no 783 0.23666642451268 1187 2839272 SGTC_340 k038-0059 454 µM 0.715779745902026 0.220663955849548 no 784 0.237063680337707 1148 23733424 SGTC_2207 7258803 200 µM 0.715118753368886 0.220875836424825 no 785 0.237267833434527 1122 3666799 SGTC_2820 7989630 71.43 µM 0.714520959940402 0.221067558847635 no 786 0.237452550079615 1064 2984098 SGTC_1563 conessine 56.1 µM 0.713132071794842 0.221513366142343 no 787 0.237882017588881 1250 441082 An anti-amoebic, histamine inhibitor. SGTC_1346 1488-2224 62.4 µM 0.710897709248315 0.222231632283239 no 788 0.23857381282783 1170 3722427 SGTC_496 calpeptin 138 µM 0.709156403880411 0.222792318753945 no 789 0.239113712060513 1141 73364 A calpain inhibitor. SGTC_2753 fluvastatin 17.09 µM 0.70903412837849 0.222831720758668 no 790 0.239151649183443 1158 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5 SGTC_2399 5884133 200 µM 0.708120754091401 0.223126171665278 no 791 0.239435136165647 1200 722445 SGTC_303 1348-1668 34.2 µM 0.707445349049662 0.223344049149976 no 792 0.239644881815615 1182 5380509 SGTC_1942 st076330 65.2 µM 0.706283675602631 0.223719073979068 no 793 0.240005871574985 1222 24208414 SGTC_1605 st000082 49.1 µM 0.699144315449295 0.226031730711028 no 794 0.242230923093994 1190 1114022 SGTC_1955 wogonin 32.4 µM 0.697337518923616 0.226619142822913 no 795 0.242795796637187 1222 5281703 A flavanone. SGTC_2395 5646831 180.19 µM 0.696846301955959 0.226778992440042 no 796 0.24294949297376 1194 6808628 SGTC_2895 9054447 58.44 µM 0.696674742039444 0.226834835682298 no 797 0.243003184566349 1219 2697450 SGTC_819 1013-0258 27.7 µM 0.695545629103746 0.227202558641685 no 798 0.243356713147844 1225 5753198 SGTC_2008 4012253 172 µM 0.694891141076991 0.2274158622357 no 799 0.243561762449795 1223 603940 SGTC_3348 9149464 3.537 µM 0.694736161880609 0.227466387877333 no 800 0.243610330667105 1211 1951442 SGTC_1448 4255-0083 152 µM 0.694648444073605 0.22749498805597 no 801 0.24363782246473 1238 5399660 SGTC_640 3381-0960 37.1 µM 0.693548647188091 0.227853746003199 no 802 0.243982653945913 1233 1745025 SGTC_549 1661-1316 519 µM 0.692438971537375 0.228216048868382 no 803 0.244330849505671 1228 2857282 SGTC_610 4215-0184 155 µM 0.691946267575896 0.22837701770743 no 804 0.244485536651026 1214 5605015 SGTC_1749 st037932 54.2 µM 0.687238403634452 0.229918313796325 no 805 0.245966253721229 1186 594497 SGTC_225 nsc-122657 1.016 µM 0.686945668687231 0.230014343477242 no 806 0.246058483339138 1144 275685 SGTC_3165 9101544 49.47 µM 0.686515617277978 0.230155459576395 no 807 0.246194009776729 1198 5002184 SGTC_2585 alliin 100 µM 0.684851458380674 0.230701989007533 no 808 0.246718829886921 1281 87310 A garlic compound which reacts with lipids. SGTC_465 cgp-37157 41 µM 0.684723558895207 0.230744022689079 no 809 0.246759189886542 1138 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange. SGTC_1585 2',4'-dihydroxychalcone 10.4 µM 0.684232239644305 0.230905532674548 no 810 0.246914263601798 1248 5357218 A potent inhibitor of glutathione S-transferases. SGTC_749 1000-0129 128 µM 0.684141533714701 0.230935357078674 no 811 0.246942898561818 1268 708470 SGTC_2741 miltefosine 3.04 µM 0.683835903223632 0.23103586520703 no 812 0.247039396149313 1133 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis. SGTC_1915 st067105 30.6 µM 0.681950711678154 0.231656359437897 no 813 0.247635058787474 1216 69751 YOR207C | YOR116C RET1 | RPO31 SGTC_1187 1391-0724 117 µM 0.680722027122307 0.23206126953132 no 814 0.248023697914198 1255 6997986 SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM 0.680635504862451 0.232089797579488 no 815 0.248051077601404 1214 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1 SGTC_501 nsc-95397 161 µM 0.679428808634303 0.232487871880189 no 816 0.248433100702706 1235 262093 SGTC_994 3910-0338 138 µM 0.679130245466772 0.232586422771334 no 817 0.248527669979513 1275 3479481 SGTC_1706 st031321 9.9705 µM 0.677954381920533 0.232974782153404 no 818 0.248900308818165 1235 6103185 SGTC_966 1300-0360 30.2 µM 0.67734873775305 0.233174952259339 no 819 0.249092357381003 1223 70588 SGTC_1323 1348-1351 11.2 µM 0.675547537269068 0.233770826827601 no 820 0.24966397999576 1182 6989654 SGTC_2463 5473429 200 µM 0.675475019987709 0.233794834712888 no 821 0.249687008404582 1192 5399405 SGTC_1096 rimcazole 32.2 µM 0.675061071927131 0.23393190431064 no 822 0.249818482324506 1173 18528119 A dopamine reuptake inhibitor. SGTC_2380 9035439 200 µM 0.674151315185668 0.234233306201226 no 823 0.250107558991462 1296 6462575 SGTC_1204 4049-0315 18.3 µM 0.673505303778814 0.234447459872537 no 824 0.250312937841644 1257 588402 SGTC_253 dyclonine 31.25 µM 0.672997124206206 0.234615998199324 no 825 0.250474560239463 1288 3180 An oral anasthetic. SGTC_2603 homopterocarpin 100 µM 0.672742308416722 0.23470053335895 no 826 0.250555623150094 1248 101795 A weak amylase inhibitor. SGTC_619 1652-1634 108 µM 0.672614970834793 0.234742783922614 no 827 0.250596137445128 1192 5400454 SGTC_2612 dictamnine 15.46 µM 0.672366035698347 0.234825392655101 no 828 0.250675349785005 1195 68085 A quinoline derivative and established mutagen. YOR116C RPO31 SGTC_2411 st077133 39.94 µM 0.669172549537963 0.235886570095804 no 829 0.251692707378637 1337 1403142 YNL221C POP1 SGTC_1693 xanthone 101.9 µM 0.669090251696523 0.235913952098058 no 830 0.251718954017313 1269 7020 An insecticide. SGTC_2386 9075165 157.42 µM 0.668393535495476 0.236145832547472 no 831 0.251941210435284 1206 16452277 SGTC_996 3970-0799 1.8 µM 0.66622386661723 0.236868743371221 no 832 0.252634010015249 1344 6615648 YGL040C HEM2 SGTC_2676 harmalol 100 µM 0.66443988537293 0.23746405749771 no 833 0.25320440606295 1247 5459187 A monoamine oxidase inhibitor SGTC_1189 1431-2119 7.28 µM 0.663845172837934 0.237662695316189 no 834 0.253394705147441 1268 3107275 SGTC_2297 7971671 152.32 µM 0.66336305571012 0.237823792428967 no 835 0.253549030544233 1271 909016 SGTC_3076 9116187 49.47 µM 0.663360049622126 0.237824797086603 no 836 0.253549992946033 1203 27241210 SGTC_1809 st050081 57.6 µM 0.659063492721255 0.239263115860881 no 837 0.254927498800297 1316 5036894 SGTC_1471 k673-0312 37 µM 0.658763342018508 0.239363771837642 no 838 0.255023875330553 1247 24099884 SGTC_868 0527-0199 213 µM 0.658675023871144 0.239393393860873 no 839 0.255052237369422 1219 2849450 SGTC_213 1246-0773 967 nM 0.657612808327006 0.239749819154563 no 840 0.255393481066009 1236 6251622 SGTC_1089 terbinafine 2.25 µM 0.655874342734162 0.240333783652264 no 841 0.255952488903238 1255 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_3055 9094636 49.47 µM 0.655511687677621 0.240455699998239 no 842 0.256069181946293 1296 25236176 SGTC_2819 7996655 46.38 µM 0.654265989315591 0.240874731768248 no 843 0.25647022681756 1164 6456960 SGTC_2765 myclobutanil 7.74 µM 0.651743952300934 0.241724317115382 no 844 0.257283181821212 1285 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11 SGTC_2221 6807166 181.081 µM 0.651309632000608 0.241870788299693 no 845 0.257423315969083 1221 674925 SGTC_1703 st026983 48.3 µM 0.650687044245959 0.242080835197603 no 846 0.257624264061715 1281 1104023 SGTC_777 1315-0167 517 µM 0.650589718893127 0.242113679487685 no 847 0.257655684413644 1232 4221767 SGTC_1401 3807-4679 7.6 µM 0.649914113267931 0.242341742032598 no 848 0.257873850620651 1271 3291456 SGTC_2453 5731132 22.18 µM 0.649171818374188 0.242592450863831 no 849 0.258113662556714 1317 1362040 SGTC_1220 1838-0075 193 µM 0.648794299822397 0.242720010967749 no 850 0.258235671173198 1201 5529645 SGTC_473 2-arachidonoylglycerol 10 µM 0.648290625008114 0.242890254652041 no 851 0.258398498231895 1233 5282280 An endocannabinoid. SGTC_2926 9010726 65.15 µM 0.647998699897318 0.242988955832639 no 852 0.258492895583007 1255 2994293 SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM 0.646928301394631 0.243351047884478 no 853 0.258839174038922 1268 91467 include heat shock SGTC_684 1140-0066 328 µM 0.646172047468449 0.243607047475182 no 854 0.259083970009361 1259 6813534 SGTC_283 0987-0079 11.7 µM 0.645799830404423 0.243733100094956 no 855 0.25920449893083 1280 411556 SGTC_968 1309-0633 340 µM 0.644476507604836 0.244181533005716 no 856 0.259633243323733 1255 3761976 SGTC_1811 st050069 61.5 µM 0.642240970474442 0.244940096396374 no 857 0.260358367498822 1266 3877702 SGTC_97 0535-0701 19.132 µM 0.641948507995323 0.245039428595097 no 858 0.260453308439343 1236 2832013 YGL099W LSG1 SGTC_692 k241-0027 77.8 µM 0.640484177902146 0.245537100581319 no 859 0.260928936116608 1350 3600480 SGTC_152 4469-0003 551.229 µM 0.63957012136339 0.245848029848274 no 860 0.261226056235646 1265 697280 SGTC_1514 1189-1591 158 µM 0.636860146642579 0.246771106859652 no 861 0.262107972040867 1354 767698 YMR146C TIF34 SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM 0.636522730879634 0.24688616785358 no 862 0.262217885064388 1335 688788 SGTC_2756 carbadox 75.1 µM 0.636384973841602 0.246933152162799 no 863 0.262262766141141 1289 2553 A substituted quinoxaline antibiotic. YLR208W SEC13 SGTC_1554 st069299 38.7 µM 0.635938320095791 0.247085523691096 no 864 0.262408312451159 1280 24207999 SGTC_1372 2752-0194 270 µM 0.634494842646745 0.247578295536545 no 865 0.262878965755584 1255 823334 SGTC_977 1348-1378 135 µM 0.633114393609036 0.248050041512554 no 866 0.263329471751837 1269 X977 SGTC_3257 9139206 32.98 µM 0.631681583646634 0.248540187718899 no 867 0.263797482195542 1257 4910041 SGTC_1065 prochlorperazine maleate 2.48 µM 0.63167516455988 0.248542384767954 no 868 0.263799579868343 1331 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine. SGTC_214 4373-3496 70 µM 0.631473805504452 0.248611308815651 no 869 0.263865385667042 1361 3779166 SGTC_2608 thymoquinone 42.66 µM 0.630610709253924 0.248906857018115 no 870 0.264147547419801 1228 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC). SGTC_1812 st052057 4.327 µM 0.630352147960962 0.248995431996514 no 871 0.264232105684951 1279 3645418 SGTC_46 0329-0187a 2.197 µM 0.6290976211495 0.24942543148458 no 872 0.264642573881064 1328 46494817 SGTC_635 k038-0028 24.7 µM 0.627700794291519 0.249904669459636 no 873 0.265099982465172 1335 4035102 SGTC_1345 1488-0192 31.4 µM 0.627424039765135 0.249999679274407 no 874 0.265190656867899 1305 658348 SGTC_2549 cedrol 20.94 µM 0.626621588642124 0.250275269025728 no 875 0.265453656752392 1296 6708665 A sedative which affects the nervous system. SGTC_314 1671-0008 2.74 µM 0.626468110151329 0.25032799724632 no 876 0.26550397373639 1232 3913060 SGTC_3269 9137823 49.47 µM 0.6257093125717 0.250588772052895 no 877 0.265752811955607 1241 17682936 SGTC_604 1000-0114 314 µM 0.62511077432151 0.250794572266296 no 878 0.265949178498498 1356 1572745 SGTC_2814 7977482 42.97 µM 0.624772508703495 0.250910920415935 no 879 0.266060188119719 1356 6456762 SGTC_1682 st012968 530 nM 0.624363782117682 0.2510515420731 no 880 0.266194352426198 1264 24207270 SGTC_2944 9067346 25.62 µM 0.62427263785518 0.251082905779866 no 881 0.266224275156621 1286 6473075 SGTC_1714 st033236 13.627 µM 0.622512225744584 0.251689088683045 no 882 0.266802553629829 1373 2916566 SGTC_699 0375-0592 111 µM 0.620320076745303 0.252445015623768 no 883 0.267523539793949 1331 762578 SGTC_1200 1643-0193 18.4 µM 0.618872067804305 0.252944993373598 no 884 0.268000320435537 1300 5403974 SGTC_1892 st058411 7.36 µM 0.617144988001081 0.253542011239511 no 885 0.268569548634248 1326 3934738 SGTC_1080 nisoldipine 24.4 µM 0.616610545344277 0.253726907538572 no 886 0.268745818616688 1286 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class. SGTC_3247 9135149 49.47 µM 0.615871740173114 0.253982621832174 no 887 0.26898958714666 1287 8934436 YOR116C RPO31 SGTC_320 4092-0846 5.34 µM 0.614740126814584 0.254374556421435 no 888 0.269363177685636 1320 1359356 SGTC_342 k048-0088 23.3 µM 0.614105446547602 0.254594516777923 no 889 0.269572824678827 1296 6820570 SGTC_1783 st039459 87.517 µM 0.614024703407579 0.254622506970053 no 890 0.269599501538579 1399 729761 SGTC_1357 1503-1303 39.5 µM 0.61390981627459 0.254662336201743 no 891 0.269637461568522 1319 292895 SGTC_1756 st041558 35.5 µM 0.613844583001234 0.254684952816233 no 892 0.26965901658397 1393 3955792 SGTC_3044 9093193 49.47 µM 0.609941314326129 0.256040142391734 no 893 0.270950341687617 1286 25236277 SGTC_3265 9137266 49.47 µM 0.60777263609418 0.256794715734261 no 894 0.271669140200915 1289 17224265 SGTC_1788 fluconazole 20 µM 0.606968810648123 0.257074693773285 no 895 0.271935805414709 1318 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11 SGTC_1808 st050063 61.5 µM 0.606400747532093 0.257272649838501 no 896 0.272124336099943 1357 4011993 SGTC_172 1112-0046 2.638 µM 0.603781967500432 0.258186253986808 no 897 0.272994304911082 1327 2802135 YIL048W NEO1 SGTC_1658 st012944 20 µM 0.602340452966068 0.258689866615403 no 898 0.273473769288225 1282 24207260 SGTC_2742 clothiapine 36.27 µM 0.602092964698569 0.25877638111282 no 899 0.273556128652214 1322 16351 An atypical antipsychotic. YIL048W NEO1 SGTC_2414 st077232 92.9 µM 0.600584391126268 0.259304056954468 no 900 0.27405841839634 1302 729801 SGTC_541 4513-1321 94 µM 0.600384727145427 0.259373937985996 no 901 0.27412493199851 1279 747515 SGTC_107 0358-0022 2.6945 µM 0.600137717549999 0.259460403121396 no 902 0.27420722877025 1382 521106 YGL093W | YPR107C SPC105 | YTH1 SGTC_2910 7948405 25.97 µM 0.600101020403107 0.259473250142539 no 903 0.27421945628658 1346 2971328 SGTC_893 0958-0369 48.9 µM 0.599500607286341 0.259683490791698 no 904 0.274419552615515 1392 6819948 SGTC_99 0109-0120 622.8 µM 0.599121328042858 0.259816344507482 no 905 0.274545990021195 1388 759414 SGTC_1705 st027868 56.3335 µM 0.598183702591624 0.260144925854336 no 906 0.274858682305519 1345 292948 SGTC_443 clozapine 122 µM 0.597502515183253 0.260383775350393 no 907 0.275085964121389 1277 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_2767 sibutramine 71.45 µM 0.597321723742211 0.260447186478844 no 908 0.275146301690907 1425 64765 A serotonin-norepinephrine reuptake inhibitor.  SGTC_2981 9013952 38.96 µM 0.595899621373659 0.260946254498863 no 909 0.275621143094983 1245 2996344 SGTC_341 1486-1430 230 µM 0.594929901374582 0.261286846695891 no 910 0.275945164455635 1299 2054753 YPL210C SRP72 SGTC_1491 4138-0063 26.5 µM 0.594202546315993 0.261542463505199 no 911 0.276188324951538 1329 23883227 SGTC_492 tmb-8 126 µM 0.593091435145605 0.261933192688789 no 912 0.276559981030109 1264 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1 SGTC_3271 9137798 49.47 µM 0.592436507488248 0.262163642217022 no 913 0.276779162863574 1310 6498326 SGTC_1640 st009078 66.4 µM 0.591088546758391 0.262638276176773 no 914 0.277230546734372 1393 690618 SGTC_296 1222-0039 74.9 µM 0.590840850786305 0.262725540847041 no 915 0.27731353040945 1307 5984176 SGTC_1961 st076550 68.7 µM 0.590805750852586 0.262737907948873 no 916 0.27732529065265 1353 1579337 SGTC_3150 9097574 49.47 µM 0.590172092129292 0.262961222307112 no 917 0.277537640129018 1361 17217476 SGTC_1049 3226-0134 66 µM 0.58841685681894 0.263580309532407 no 918 0.278126262946697 1372 5702385 SGTC_3114 9122766 49.47 µM 0.588028497449111 0.263717387772856 no 919 0.278256582511598 1295 17176985 SGTC_1531 st059297 52.4 µM 0.586907082976227 0.264113414632018 no 920 0.278633056260171 1376 7566702 SGTC_3181 9108277 49.47 µM 0.586184155381236 0.264368876601854 no 921 0.278875884082648 1304 17097298 SGTC_1213 1315-0166 115 µM 0.585974376084185 0.264443030154246 no 922 0.27894636718685 1311 768401 SGTC_1794 st048918 76.9 µM 0.585493915368897 0.264612905040343 no 923 0.279107828357254 1313 672303 SGTC_3164 9100705 49.47 µM 0.583005716807152 0.265493536294531 no 924 0.279944725882125 1405 17174235 SGTC_1570 verbenone 133 µM 0.581451918825736 0.26604421465542 no 925 0.280467957236033 1403 29025 A natural terpanoid with antifungal properties. SGTC_1403 3909-7815 62.9 µM 0.581196311562754 0.266134859282984 no 926 0.280554076638927 1371 6615483 SGTC_3345 9148410 3.559 µM 0.58065773730637 0.26632590214705 no 927 0.280735575383528 1360 4903596 SGTC_1183 1254-0324 198 µM 0.578759999530057 0.266999619649234 no 928 0.281375562466206 1423 5799357 SGTC_1990 st072050 59.8 µM 0.57861849918973 0.267049888264999 no 929 0.281423309787404 1358 17233948 SGTC_2550 chrysin dimethyl ether 71.87 µM 0.577190622113239 0.267557415132527 no 930 0.281905345704423 1283 88881 An O-methylated flavonoid and antioxidant. SGTC_726 3448-4391 34.2 µM 0.576581754974545 0.267773979622348 no 931 0.28211101359786 1479 1356692 SGTC_3215 9129942 49.47 µM 0.576471508287969 0.267813202080842 no 932 0.282148261307178 1334 17682944 SGTC_1838 st055369 84.5 µM 0.575876403043447 0.268024972611697 no 933 0.28234936316093 1336 676036 SGTC_1900 st060200 72.8 µM 0.574903627264151 0.268371320123416 no 934 0.282678238318548 1386 688945 SGTC_383 2324-0395 7.37 µM 0.574770871477383 0.268418604000577 no 935 0.282723134546683 1426 3146421 SGTC_1007 4101-0031 70 µM 0.574273262182566 0.268595875706448 no 936 0.282891449825077 1384 1146276 SGTC_106 0092-0003 11.579 µM 0.573934689006927 0.268716524935757 no 937 0.283005998978839 1412 1072148 SGTC_1045 1348-1485 165 µM 0.570268508992555 0.270024694977163 no 938 0.284247798087587 1375 6810614 SGTC_3067 9117431 49.47 µM 0.56941571377758 0.270329446419565 no 939 0.284537027698131 1376 17150885 SGTC_2994 9053520 71.4286 µM 0.565273290457941 0.271812207728697 no 940 0.285943946476158 1440 4647384 SGTC_2985 9022375 71.43 µM 0.563000438522034 0.272627480505006 no 941 0.286717292665854 1395 4939335 SGTC_2544 sphondin 68.51 µM 0.562829866122037 0.272688713810613 no 942 0.286775370528613 1428 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31 SGTC_1351 1496-0003 46.5 µM 0.561519221406229 0.273159446042886 no 943 0.287221815323773 1392 3891978 SGTC_2041 5107442 45.335 µM 0.560805231962747 0.273416052394391 no 944 0.287465159817026 1406 793005 SGTC_3326 9140064 16.379 µM 0.560471869867969 0.273535902910541 no 945 0.287578810884417 1357 1868434 SGTC_369 0957-0393 4.5 µM 0.558625371609862 0.274200227450356 no 946 0.288208710414536 1354 6997992 SGTC_2167 5876490 200 µM 0.555930735573275 0.275171118778461 no 947 0.289129102967062 1593 686534 SGTC_161 4065-0411 162.148 µM 0.55471269924699 0.27561053839706 no 948 0.289545594274748 1448 1906281 YLR208W SEC13 SGTC_740 k014-0057 261 µM 0.554574715606792 0.275660339217963 no 949 0.289592793702754 1476 4012779 SGTC_1180 1193-0155 285 µM 0.554288165682566 0.275763774460465 no 950 0.289690824053263 1379 2921347 SGTC_910 3454-3003 490 µM 0.552912468008667 0.276260622209884 no 951 0.290161674743229 1358 820824 SGTC_588 3970-1144 52.9 µM 0.552823145226585 0.276292897255916 no 952 0.290192259038006 1400 1888707 SGTC_2963 9082507 9 µM 0.552103111838473 0.276553134826212 no 953 0.290438855016036 1440 16459611 SGTC_3354 9151612 71.43 µM 0.551322180928825 0.276835518007717 no 954 0.290706417924094 1466 27261949 SGTC_585 0kpi-0023 191 µM 0.550880180912048 0.276995406962016 no 955 0.290857907243782 1439 64601 SGTC_1744 st037937 38.9 µM 0.550409791779825 0.277165615025594 no 956 0.291019167055699 1457 1016152 SGTC_1828 st055811 49 µM 0.549963379725699 0.277327194409068 no 957 0.291172245612859 1389 5877589 SGTC_1161 k007-0610 110 µM 0.549660422955774 0.277436876210016 no 958 0.291276153522486 1460 5843850 SGTC_1010 4112-3296 15.2 µM 0.54831037393261 0.27792590261637 no 959 0.291739402711313 1460 704384 SGTC_233 rapamycin 362 pM 0.547760725982131 0.278125121279182 no 960 0.291928104505263 1439 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C SGTC_3160 9100216 49.47 µM 0.547484941694298 0.278225104908263 no 961 0.292022806501052 1383 17191039 SGTC_1365 1672-3266 55.4 µM 0.54695989971149 0.278415503569755 no 962 0.292203141007702 1440 6415873 SGTC_2469 5655019 90.81 µM 0.546007129466985 0.278761173585107 no 963 0.292530518237004 1514 2788239 SGTC_1891 st059073 26.2 µM 0.54475285933248 0.279216547611126 no 964 0.292961752237715 1514 688754 SGTC_407 eburnamonine 100 µM 0.543662859779816 0.279612575128764 no 965 0.293336747315349 1368 3195 SGTC_1229 0139-0193 12.2 µM 0.54291476042379 0.279884538373761 no 966 0.293594246327253 1477 3090752 SGTC_2402 5553605 200 µM 0.542549115719998 0.280017511120098 no 967 0.293720140869702 1488 6758546 SGTC_892 0929-0076 29 µM 0.542255756758715 0.280124218097786 no 968 0.293821164883186 1410 5751038 SGTC_3047 9092122 49.47 µM 0.540995455011932 0.280582866830375 no 969 0.294255357704598 1379 17173831 SGTC_2384 9036245 200 µM 0.53985156711891 0.280999464581489 no 970 0.294649700596198 1484 6462766 SGTC_531 3788-1495 174 µM 0.539273335585842 0.281210167034459 no 971 0.294849132332165 1409 2896655 SGTC_503 tyrphostin 8 294 µM 0.53896747297382 0.281321651505918 no 972 0.294954649332409 1434 92970 A tyrosine kinase inhibitor. YOR207C RET1 SGTC_2561 acetosyringone 100 µM 0.538236169247399 0.281588292308575 no 973 0.295207006233068 1392 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent. SGTC_904 1141-0088 396 µM 0.537834932581429 0.281734639056798 no 974 0.295345506434176 1342 1378119 SGTC_3246 9135460 32.98 µM 0.537233982086044 0.281953897828517 no 975 0.295553000423144 1449 41446951 SGTC_1262 0737-0114 49.6 µM 0.536803754925046 0.282110918098847 no 976 0.295701588839786 1446 765919 SGTC_129 0088-0017 176.636 µM 0.536563786681156 0.28219851774232 no 977 0.295784482064272 1422 182446 SGTC_1989 st071868 50.2 µM 0.53543891606218 0.28260932261668 no 978 0.296173193013986 1494 16414057 SGTC_109 0132-0036 33.701 µM 0.535033402843531 0.282757487268865 no 979 0.296313379847797 1345 67274 A color developer. SGTC_2282 7944268 200 µM 0.533750626962123 0.283226427921619 no 980 0.296757038591273 1506 2970414 SGTC_1038 k292-0204 154 µM 0.533728443236315 0.283234540842302 no 981 0.296764713692399 1367 4454212 SGTC_1980 st071811 45.7 µM 0.533636670559826 0.28326810466861 no 982 0.296796466067929 1476 4974850 SGTC_1246 0422-0085 105 µM 0.533093287640896 0.283466874027455 no 983 0.2969845026671 1454 264295 SGTC_2839 9003951 25.97 µM 0.532500387545831 0.283683832997186 no 984 0.297189736737025 1441 2990634 SGTC_3272 9137413 49.47 µM 0.531870939905434 0.283914252753846 no 985 0.29740769276549 1350 17614870 SGTC_3266 9136860 49.47 µM 0.530697179185033 0.284344166439386 no 986 0.297814320542252 1387 4871271 YPR165W RHO1 SGTC_1982 st072467 71.9 µM 0.528288452574446 0.285227384485574 no 987 0.298649572546894 1435 3163533 SGTC_2991 9074669 71.4286 µM 0.528155873554897 0.285276035730821 no 988 0.298695576667971 1525 17333109 SGTC_1252 0493-0875 34.8 µM 0.527989297920264 0.285337167989939 no 989 0.29875338197603 1427 3960963 SGTC_943 3253-1379 105 µM 0.527830700448326 0.285395378109307 no 990 0.298808423415786 1515 668464 SGTC_2520 obtusaquinone 4.71 µM 0.527269444850484 0.285601421473398 no 991 0.299003244833164 1535 5967872 SGTC_535 2293-4129 48.2 µM 0.526792608039926 0.285776529335122 no 992 0.299168808352639 1541 396118 YIL048W NEO1 SGTC_717 1532-0246 73.2 µM 0.525462558764057 0.286265230438318 no 993 0.299630837309606 1407 9561992 SGTC_8 0354-0001 70 µM 0.525407471209645 0.28628547985923 no 994 0.299649980447313 1476 4993152 SGTC_431 k089-0097 107 µM 0.524885356535111 0.286477435733319 no 995 0.299831444817575 1381 5499420 SGTC_1076 itraconazole 331 nM 0.524164837880116 0.28674243523554 no 996 0.300081947460021 1445 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1 SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM 0.523612226711819 0.28694575876706 no 997 0.300274137847692 1413 4174840 SGTC_3050 9093513 49.47 µM 0.523287363613745 0.287065318283074 no 998 0.300387146623358 1420 25236664 SGTC_2088 5278280 127.392 µM 0.522808582966149 0.287241567137476 no 999 0.300553733078205 1470 791502 SGTC_487 nimodipine 119 µM 0.522122439920354 0.28749423954151 no 1000 0.300792541697428 1430 4497 L-type voltage-gated calcium channels inhibitor SGTC_3048 9093155 49.47 µM 0.521579617332841 0.287694208573117 no 1001 0.300981528984736 1428 25236002 SGTC_3148 9097893 49.47 µM 0.52114169845527 0.287855580279253 no 1002 0.30113403235187 1339 17174100 SGTC_3002 9075603 71.4286 µM 0.520372578375875 0.288139101996146 no 1003 0.301401959352474 1427 20105405 SGTC_1565 sinapyl alcohol 95.1 µM 0.519650787141484 0.288405296607747 no 1004 0.301653496661331 1384 5280507 A phenol propionate derived from cinnamic acid. SGTC_2541 muurolladie-3-one 83.07 µM 0.518835829170449 0.288705990118927 no 1005 0.301937615098263 1471 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils.  YMR203W TOM40 SGTC_451 chloral hydrate 100 µM 0.518029608626101 0.289003604987509 no 1006 0.302218805644012 1489 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1 SGTC_305 1682-2595 20.8 µM 0.516904028370256 0.28941935216483 no 1007 0.302611577702071 1479 226033 SGTC_3216 9129716 49.47 µM 0.516600651420628 0.289531456293196 no 1008 0.30271748043554 1395 8056934 SGTC_1922 5578187 25 µM 0.51564657910201 0.289884138798444 no 1009 0.303050635859634 1553 1350412 SGTC_287 k060-0039 29.6 µM 0.514629579429725 0.290260304753526 no 1010 0.303405945589859 1541 5861974 SGTC_973 1325-0077 65.9 µM 0.513637029416396 0.290627647628242 no 1011 0.303752892687443 1570 2835149 SGTC_870 0573-2213 57.6 µM 0.513497761354653 0.290679208147883 no 1012 0.30380158817214 1422 3916321 SGTC_3168 9103419 49.47 µM 0.513106916755812 0.290823931441238 no 1013 0.303938266726727 1439 16649256 SGTC_2783 7738165 71.43 µM 0.513081245843264 0.290833438134527 no 1014 0.303947244817421 1372 17201110 SGTC_1805 st050013 60.3 µM 0.512875317257885 0.290909704797584 no 1015 0.304019270124365 1494 4037144 SGTC_2659 sanguinarine 24.21 µM 0.511812406971594 0.291303507396038 no 1016 0.304391153126204 1445 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis. SGTC_1011 4112-3381 17.4 µM 0.511731342379659 0.291333551603914 no 1017 0.304419523700989 1505 2877139 SGTC_2522 biochanin a 4.94 µM 0.510495554076571 0.291791739154068 no 1018 0.304852164270093 1509 5280373 A possible chelator. SGTC_467 ro 31-8220 72.8 µM 0.510177749980048 0.291909624169711 no 1019 0.304963469345542 1468 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7 SGTC_3103 9120822 49.47 µM 0.509789101368591 0.29205381811576 no 1020 0.305099610947895 1523 17141819 SGTC_82 0054-0107 293.755 µM 0.509325008220646 0.292226046438265 no 1021 0.305262215720105 1531 3104697 SGTC_2831 7999036 19.48 µM 0.508714909335218 0.292452530404405 no 1022 0.305476035144457 1637 2988270 SGTC_2429 5902844 64.44 µM 0.507911810206125 0.292750785223374 no 1023 0.305757595931989 1553 1927790 YGL093W | YPR107C SPC105 | YTH1 SGTC_1784 st039334 36.3 µM 0.507764052520936 0.292805674828128 no 1024 0.305809411231013 1553 3496984 SGTC_2151 5563267 85.4165 µM 0.505767481565041 0.293547836888527 no 1025 0.306509944626233 1472 5310824 SGTC_1802 st050112 57.9 µM 0.50576397126344 0.293549142498824 no 1026 0.306511176903559 1465 4662563 SGTC_1121 fusaric acid 630.51 nM 0.505496793649973 0.293648523571947 no 1027 0.306604974954693 1447 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler. SGTC_1853 st056710 91.2 µM 0.505202420435942 0.293758038522279 no 1028 0.306708335234713 1639 269167 SGTC_2848 9016370 25.97 µM 0.504839998546979 0.29389289540687 no 1029 0.306835609868704 1525 7894410 SGTC_1661 st013063 9.66 µM 0.504143816679753 0.294152024399251 no 1030 0.307080159025502 1491 721395 SGTC_1906 st060206 94.7 µM 0.503898865786051 0.294243223777806 no 1031 0.307166223822439 1506 5133468 SGTC_2630 antimycin a 100 µM 0.503699540626719 0.294317445557755 no 1032 0.307236265615297 1417 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain. SGTC_1717 st033143 58.0435 µM 0.502696468652418 0.294691085957706 no 1033 0.307588846432263 1587 674616 SGTC_988 1497-1057 103 µM 0.499263630803351 0.295971457123242 no 1034 0.308796836496186 1536 3533044 SGTC_1455 4262-0120 131 µM 0.498785879435404 0.296149849883594 no 1035 0.30896511814437 1554 1529587 SGTC_397 arbidol 50 µM 0.497485319536077 0.296635729803264 no 1036 0.309423426406252 1565 131410 A RNA synthesis inhibitor. SGTC_2802 7925815 54.55 µM 0.495416574816552 0.297409349444345 no 1037 0.310153048592861 1463 1262923 SGTC_858 0438-0351 2.77 µM 0.495275802714704 0.297462025496928 no 1038 0.310202724488915 1462 2799119 SGTC_1976 st070609 63.5 µM 0.495246259421904 0.297473080955816 no 1039 0.310213150215508 1456 682556 SGTC_2978 9011784 42.97 µM 0.494635301977131 0.297701750698278 no 1040 0.310428789185727 1666 2994934 SGTC_926 2268-1401 59.4 µM 0.494137095360449 0.297888279296552 no 1041 0.310604680713608 1451 2931578 SGTC_2372 9071633 200 µM 0.492542450776522 0.298485672296218 no 1042 0.311167959947304 1524 21321366 SGTC_1299 1079-1439 3.74 µM 0.490031939881474 0.299427274142326 no 1043 0.312055648780646 1445 323161 SGTC_405 ebelactone b 50 µM 0.488644840962727 0.299948101754438 no 1044 0.312546580528593 1481 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).  SGTC_3128 9127691 49.47 µM 0.487391967281596 0.300418882585832 no 1045 0.312990292470439 1509 41316314 SGTC_3200 9114385 49.47 µM 0.486682095843695 0.300685772520197 no 1046 0.313241817573013 1462 17018030 YLR208W SEC13 SGTC_2481 5478948 45.16 µM 0.485317995096098 0.30119893280264 no 1047 0.313725396277811 1484 77792 SGTC_3085 9117376 49.47 µM 0.484485662995843 0.301512241014552 no 1048 0.314020618412802 1562 16480349 SGTC_2149 5554786 194.827 µM 0.484044779253083 0.301678258795554 no 1049 0.31417704491689 1508 745063 YPR165W RHO1 SGTC_2162 5663267 200 µM 0.483255423709301 0.30197559864372 no 1050 0.314457193350224 1590 6456493 SGTC_3182 9108849 49.47 µM 0.480929369633175 0.302852557110498 no 1051 0.315283349117224 1496 17133045 SGTC_425 3825-7017 13.1 µM 0.478871974488353 0.303629175913227 no 1052 0.316014854787757 1579 3397440 SGTC_1397 3532-0190 20.1 µM 0.477611964387559 0.30410523895417 no 1053 0.316463206834088 1529 5322280 SGTC_538 2922-0838 53.3 µM 0.477515199152005 0.304141813008072 no 1054 0.316497650178118 1640 777039 SGTC_1974 st069448 26.9 µM 0.477027680107698 0.304326108862789 no 1055 0.316671205568355 1593 6323587 YNR016C ACC1 SGTC_3190 9110366 49.47 µM 0.473467308120355 0.305673533893053 no 1056 0.317939909683579 1614 17123768 SGTC_156 3474-0145 5.642 µM 0.472471977315816 0.306050689638145 no 1057 0.318294969560297 1617 2265471 SGTC_212 3807-4682 38.772 µM 0.472416585413928 0.306071685061574 no 1058 0.318314734172476 1624 3125501 YBL034C STU1 SGTC_1342 1486-1464 234 µM 0.471701691090343 0.306342711586419 no 1059 0.318569864950281 1507 3253938 SGTC_2165 5727197 32.143 µM 0.471344677883601 0.306478100022494 no 1060 0.318697307692192 1605 1361712 SGTC_1710 st031758 61.5 µM 0.471159258259351 0.306548426257853 no 1061 0.318763505262017 1599 5394341 SGTC_3293 9120939 62.045 µM 0.47004378803691 0.306971653766257 no 1062 0.319161866747795 1572 934087 SGTC_491 tetrandrine 80.3 µM 0.46936490726634 0.307229358169047 no 1063 0.319404413838801 1575 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_477 mead ethanolamide 10 µM 0.466936420464428 0.308151995180894 no 1064 0.320272683538194 1480 16061185 SGTC_450 aminopyrene 156 nM 0.466059249144615 0.308485551042837 no 1065 0.320586545616274 1586 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1 SGTC_254 nsc-64875 3.808 µM 0.465675066729404 0.308631691241615 no 1066 0.320724050967859 1644 56993 SGTC_2316 5844804 197.44 µM 0.463959246459507 0.309284746596555 no 1067 0.321338471999748 1622 776813 SGTC_1031 k035-0009 16 µM 0.463942680489923 0.309291054683214 no 1068 0.321344406523523 1653 5180959 SGTC_3260 9137109 49.47 µM 0.462106891898546 0.309990444900657 no 1069 0.322002334060052 1599 17478346 SGTC_2800 7887935 81.82 µM 0.462068893036921 0.31000492880788 no 1070 0.322015958361353 1573 2961002 SGTC_1315 1237-0019 3.69 µM 0.461788455139591 0.310111831560437 no 1071 0.322116515359734 1608 825140 SGTC_2684 capsaicin 100 µM 0.461709662366088 0.310141870205729 no 1072 0.322144770535558 1523 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_1617 st002906 78 µM 0.461486420340464 0.310226984992148 no 1073 0.3222248309547 1526 5150859 SGTC_1562 morin hydrate 59.1 µM 0.459762717816134 0.31088451767446 no 1074 0.322843273169247 1560 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase. SGTC_1441 4106-0040 13 µM 0.45975877700029 0.31088602165206 no 1075 0.322844687645415 1519 2904180 SGTC_2909 7941780 10.49 µM 0.45927209856582 0.311071782462499 no 1076 0.323019390725272 1615 1243215 SGTC_2324 6149169 200 µM 0.458966602520479 0.311188412171016 no 1077 0.323129074670873 1578 2888231 SGTC_1226 3909-7979 35.4 µM 0.458934657777713 0.311200608861114 no 1078 0.323140544858028 1625 6615510 SGTC_995 3931-2021 34.6 µM 0.457920873886314 0.311587785117572 no 1079 0.32350464482385 1578 730143 SGTC_801 0866-0028 10.1 µM 0.456306707807842 0.312204684542519 no 1080 0.324084720524997 1549 6849771 SGTC_1485 3909-9022 254 µM 0.456000911862192 0.312321612567697 no 1081 0.324194661249218 1540 714516 SGTC_960 1222-0186 7.7 µM 0.454817904526718 0.312774140224566 no 1082 0.324620124093085 1631 3126296 SGTC_2103 5378138 10 µM 0.454260826607514 0.312987333226574 no 1083 0.324820553792741 1596 244142 SGTC_3029 9088683 49.47 µM 0.453563109762221 0.313254436789066 no 1084 0.325071655174243 1557 25236615 SGTC_754 3474-0146 171 µM 0.452127215404874 0.31380444153457 no 1085 0.325588669305573 1451 24762078 SGTC_1795 st049545 62.3 µM 0.451486014015701 0.314050181009571 no 1086 0.325819651454893 1635 5291882 SGTC_1470 k295-0292 231 µM 0.45091506214169 0.314269066885226 no 1087 0.326025383673934 1615 5045612 SGTC_3203 9113543 49.47 µM 0.450560033856894 0.314405207060719 no 1088 0.326153338432892 1600 17018012 SGTC_521 r062-0005 13.8 µM 0.449727714754344 0.31472446950057 no 1089 0.326453392473562 1547 2832033 SGTC_365 0121-0052 13.6 µM 0.44751548727539 0.315573712664428 no 1090 0.327251454107049 1589 3101739 SGTC_1061 3448-9325 110 µM 0.447202771996829 0.315693838430196 no 1091 0.327364330064206 1549 723482 SGTC_3251 9135047 49.47 µM 0.445658437245229 0.316287361169024 no 1092 0.327921995809415 1655 17682963 SGTC_1924 st058459 75.1 µM 0.445307345513354 0.316422359782778 no 1093 0.328048830107254 1548 688683 SGTC_2703 st077852 53.4 µM 0.443775108730413 0.317011807781723 no 1094 0.328602593127206 1577 6281836 SGTC_1113 artemisinin 1.17947 µM 0.443588338708548 0.317083689585598 no 1095 0.32867011913066 1663 2240 An anti-malaria and mitochondrial poison. SGTC_1335 1486-0900 202 µM 0.442790765097387 0.317390727793603 no 1096 0.328958541823851 1544 X1335 SGTC_2584 androsterone 48.74 µM 0.442623032197521 0.317455315152602 no 1097 0.329019211232765 1574 2754130 A steroid. SGTC_1865 st057639 52.2 µM 0.442398642284306 0.317541727595393 no 1098 0.329100380668344 1554 688818 SGTC_2999 9069765 71.4286 µM 0.44183828012065 0.317757566193228 no 1099 0.329303117833036 1618 2097066 SGTC_1748 st037455 53.6035 µM 0.440062059834009 0.318442134418743 no 1100 0.329946079936756 1616 580690 SGTC_2532 xanthone 78.9 µM 0.439767460339581 0.318555735247155 no 1101 0.330052768690677 1634 7020 An insecticide. SGTC_1841 st054148 70 µM 0.439054403350282 0.318830768517068 no 1102 0.330311058387863 1516 675442 SGTC_3334 9142812 21.919 µM 0.438862324148819 0.318904872471451 no 1103 0.330380648816451 1608 45283678 SGTC_3026 9090633 49.47 µM 0.437932874356507 0.319263555460355 no 1104 0.330717471961379 1537 25236842 SGTC_4 0960-0234 25.671 µM 0.437661076235806 0.319368476781113 no 1105 0.330815994757681 1558 6821112 SGTC_3332 9141069 11.198 µM 0.436805492637287 0.319698849265875 no 1106 0.331126207639417 1524 17332883 SGTC_2919 7978188 46.38 µM 0.436701840182456 0.319738883038034 no 1107 0.331163797265351 1693 2980291 SGTC_1152 3909-8331 15.9 µM 0.436148373614535 0.319952684419375 no 1108 0.331364541045363 1566 16001939 SGTC_553 k007-0256 45.7 µM 0.43554851176325 0.320184475618093 no 1109 0.331582167243372 1592 6287000 SGTC_2248 tofa 1.1 µM 0.435312707448753 0.320275611429383 no 1110 0.331667731175631 1591 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_1379 2144-0755 36.5 µM 0.434885794019367 0.320440636422048 no 1111 0.331822663287469 1662 5392327 SGTC_2818 7996756 12.99 µM 0.434223258565439 0.320696812301828 no 1112 0.332063162473629 1545 2241621 SGTC_2931 9014674 55.67 µM 0.434130658106196 0.320732623990656 no 1113 0.332096781788596 1508 2996810 SGTC_2858 9025781 8.96 µM 0.432841087576571 0.321231517240273 no 1114 0.33256511073629 1604 4894980 YPL153C RAD53 SGTC_1569 carminic acid 40.6 µM 0.432770164953051 0.321258964288055 no 1115 0.332590875056179 1649 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_2641 levomentholum 100 µM 0.430100703360831 0.322292754433388 no 1116 0.333561194206594 1572 16666 SGTC_265 mycophenolic acid 32.932 µM 0.427938795117245 0.323130995712214 no 1117 0.334347840642578 1648 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1 SGTC_2330 7979373 200 µM 0.427598156053832 0.323263154507074 no 1118 0.334471854334736 1482 1863007 SGTC_1479 0549-0158 134 µM 0.427119831902794 0.323448769064217 no 1119 0.33464602440672 1587 5440202 SGTC_1297 1068-0111 14.1 µM 0.426882837109588 0.323540751608477 no 1120 0.334732333465956 1541 767057 SGTC_237 nikkomycin 200 µM 0.425203350473246 0.324192903553931 no 1121 0.33534422097925 1662 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine. SGTC_537 1334-0398 209 µM 0.424899647173271 0.324310890549276 no 1122 0.335454915939581 1699 5846986 SGTC_672 1441-0018 53.7 µM 0.423850628037471 0.324718564138034 no 1123 0.335837376351885 1553 251141 SGTC_545 4218-0007 221 µM 0.422375294428728 0.325292268981701 no 1124 0.336375553900633 1597 2840508 SGTC_1844 rapamycin 4 nM 0.421449757144226 0.325652389146127 no 1125 0.336713346050377 1594 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2 SGTC_2735 sertaconazole 140 nM 0.421392193896513 0.325674791988307 no 1126 0.336734359190263 1666 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C SGTC_2953 9074162 66.49 µM 0.421010967462115 0.325823176081226 no 1127 0.3368735366198 1746 16451992 SGTC_2354 9060492 162 µM 0.420702372982666 0.325943309977486 no 1128 0.336986214073581 1707 6471895 SGTC_689 0833-0039 98 µM 0.418499983778195 0.326801210376026 no 1129 0.337790799203434 1700 5374726 SGTC_2817 7995342 71.43 µM 0.4156691781467 0.327905244553502 no 1130 0.338826049017386 1508 18879975 SGTC_1818 st052136 56.3 µM 0.415233417247021 0.32807532834611 no 1131 0.338985518929805 1545 674169 SGTC_1988 st071872 53.4 µM 0.414011452423296 0.328552469013259 no 1132 0.339432859804424 1673 16414116 SGTC_65 0798-0905 34.986 µM 0.412976929969231 0.328956637726887 no 1133 0.339811758133824 1795 3602145 SGTC_1821 st053465 65.6 µM 0.411724347998014 0.329446265995268 no 1134 0.340270738376429 1573 675086 SGTC_2935 9038016 29.96 µM 0.411061407422931 0.329705524734629 no 1135 0.340513753762255 1634 6463195 SGTC_1210 3013-0140 750 nM 0.410443104877352 0.329947400481586 no 1136 0.340740465796194 1742 905973 SGTC_2102 5377816 72.7585 µM 0.410148834604948 0.330062541991643 no 1137 0.340848385634254 1735 1379702 SGTC_2014 4013930 200 µM 0.408769694870163 0.33060238352917 no 1138 0.341354340850167 1616 64556 SGTC_318 1488-0629 67.2 µM 0.408077730734903 0.330873374408951 no 1139 0.341608304364463 1582 3662576 SGTC_1529 apigenin 74 µM 0.407609951521561 0.331056618960122 no 1140 0.341780028543269 1704 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_758 0868-0029 16 µM 0.405206434542617 0.331998793310108 no 1141 0.342662887810581 1741 762687 SGTC_2809 7964133 12.99 µM 0.402687266369059 0.332987444049441 no 1142 0.34358915131176 1636 1253665 SGTC_519 k048-0011 62.8 µM 0.401197702128028 0.333572572610645 no 1143 0.344137286203486 1668 6836379 SGTC_917 harmaline 728.087 nM 0.400550481765713 0.333826939147415 no 1144 0.344375554720574 1669 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7 SGTC_2308 7584454 197.62 µM 0.400084157911229 0.334010258209432 no 1145 0.344547266065589 1712 893577 SGTC_1468 k284-1086 134 µM 0.399785131604718 0.33412783088696 no 1146 0.344657391403732 1628 15996457 SGTC_3058 9093861 49.47 µM 0.399563366945309 0.334215035952775 no 1147 0.34473907134372 1650 17217477 SGTC_60 0986-0278 202 µM 0.399236411889856 0.334343621621211 no 1148 0.34485950801239 1451 3110598 SGTC_790 1575-0012 79.1 µM 0.398445626639199 0.334654703886129 no 1149 0.345150865445385 1693 378741 YLR208W SEC13 SGTC_2141 5621638 7.665 µM 0.398441113881712 0.334656479458702 no 1150 0.345152528392319 1734 2856238 SGTC_2860 9025725 38.96 µM 0.39767772726474 0.334956891870298 no 1151 0.34543387866204 1572 40546248 SGTC_839 0122-0028 230 µM 0.397573403304543 0.334997954259765 no 1152 0.345472334460154 1649 759448 SGTC_586 0957-0265 8.15 µM 0.397097994378963 0.335185102362639 no 1153 0.345647599433067 1664 6752309 YPR165W | YPR107C RHO1 | YTH1 SGTC_536 3852-0578 10.6 µM 0.396619436337175 0.335373531465166 no 1154 0.345824058783691 1732 2869208 SGTC_1027 k015-0025 8.67 µM 0.396070563452366 0.335589697574783 no 1155 0.346026486659029 1585 3598955 SGTC_87 0100-0052 35.5 µM 0.395256361333675 0.335910460223524 no 1156 0.346326850725561 1691 200187 YGR083C | YDR527W GCD2 | RBA50 SGTC_954 1189-0853 2.85 µM 0.394804628555119 0.336088476220329 no 1157 0.346493539378848 1615 2828194 SGTC_1418 3966-3099 2.4 µM 0.394065451131821 0.336379845878175 no 1158 0.346766358748079 1696 740335 SGTC_263 alizarin 107.927 µM 0.393620178010564 0.336555411511417 no 1159 0.346930740787609 1668 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. SGTC_2859 9028643 45.46 µM 0.390774156664972 0.337678402600865 no 1160 0.347982089546382 1705 17151580 SGTC_667 1498-1044 59 µM 0.390171531964112 0.337916373891266 no 1161 0.348204855469762 1676 6739982 SGTC_890 0929-0006 47.2 µM 0.388879154596723 0.338426940940664 no 1162 0.34868277154055 1594 1378169 SGTC_1526 st051518 75 µM 0.387132057561971 0.339117621997136 no 1163 0.349329222949893 1629 673993 SGTC_1857 st056007 79.3 µM 0.386753204371286 0.339267465745965 no 1164 0.349469461924973 1662 619834 SGTC_3308 9128332 17.569 µM 0.384032883609145 0.340344150509742 no 1165 0.350477037581843 1768 17332805 YDL196W YDL196W SGTC_2485 5633444 17.78 µM 0.38350696618874 0.340552455657868 no 1166 0.350671953053193 1604 5724239 SGTC_353 1988-1175 58.3 µM 0.382589545091246 0.340915943830412 no 1167 0.351012061671685 1583 2788357 SGTC_896 0964-0007 44.5 µM 0.382173495771717 0.341080833970769 no 1168 0.351166339870246 1736 6756758 SGTC_3241 9133421 49.47 µM 0.381267364623787 0.341440060092777 no 1169 0.351502433655775 1673 17018221 SGTC_1141 3253-0389 52.6 µM 0.380209479950113 0.341859629097528 no 1170 0.351894961374706 1738 5402031 SGTC_264 promethazine 12.5 mM 0.380120020740759 0.341895118597487 no 1171 0.35192816242822 1644 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3 SGTC_170 4197-0004 226 µM 0.379470837298306 0.342152698994347 no 1172 0.352169128103854 1722 218692 SGTC_2183 6420625 130.508 µM 0.378982934169988 0.342346335599561 no 1173 0.352350268395223 1616 2897619 SGTC_1452 4194-0072 190 µM 0.378738665758558 0.3424432952258 no 1174 0.352440968760037 1802 1343545 SGTC_1674 st016616 23.6 µM 0.378710263574899 0.342454569830419 no 1175 0.352451515442884 1590 625830 SGTC_144 4161-2749 112.381 µM 0.378411634331521 0.342573122967192 no 1176 0.352562413356706 1647 797501 YMR168C CEP3 SGTC_2602 kawain 100 µM 0.377657793992698 0.342872459803752 no 1177 0.352842412604666 1651 5369129 SGTC_574 1315-0397 40 µM 0.37716372691061 0.343068698750376 no 1178 0.353025967415344 1641 6794277 SGTC_767 0929-0023 86 µM 0.377162824863019 0.343069057074198 no 1179 0.353026302573551 1647 1204563 SGTC_634 1611-4317 11.2 µM 0.3765408475025 0.3433161611052 no 1180 0.353257427066056 1750 2843522 SGTC_2144 5628481 200 µM 0.374744372249761 0.344030254748122 no 1181 0.353925294363524 1679 2818399 SGTC_919 tnp00227 403.569 nM 0.373730158650962 0.344433647681133 no 1182 0.35430254262008 1683 1269246 A methoxyflavone. YNL221C POP1 SGTC_2711 st079103 59.1 µM 0.373617151137031 0.344478606215739 no 1183 0.354344585909066 1765 54693780 SGTC_2262 9014885 67.46 µM 0.373485727389655 0.34453089416709 no 1184 0.35439348300187 1786 6457424 SGTC_1087 pterostilbene 9.05 µM 0.373151635944227 0.34466382839825 no 1185 0.354517794784757 1770 5281727 Similar to reservatol, lowers cholesterol. SGTC_1803 st050068 52.4 µM 0.373136754282308 0.344669750224299 no 1186 0.354523332449486 1683 3984059 YIL048W | YNL267W NEO1 | PIK1 SGTC_2097 5376186 200 µM 0.372165027093149 0.345056509751437 no 1187 0.354884991596428 1767 742755 SGTC_3322 9139058 2.11 µM 0.372122413333118 0.345073474267686 no 1188 0.354900854657431 1721 4908926 YPR165W RHO1 SGTC_1088 bifonazole 369 nM 0.371321443621097 0.345392397800324 no 1189 0.355199064074443 1650 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase. SGTC_733 4069-0007 56.1 µM 0.371236270824202 0.345426317666709 no 1190 0.355230780020012 1712 5717425 YNL287W SEC21 SGTC_285 1486-1325 46 µM 0.371198995056873 0.345441163044077 no 1191 0.35524466077916 1731 22310230 SGTC_1421 4029-0249 71.4 µM 0.371184198009835 0.345447056154274 no 1192 0.355250170960329 1791 2894095 SGTC_632 0781-2353 4.65 µM 0.370005324228944 0.345916677753591 no 1193 0.355689261668862 1709 6811515 YHR007C ERG11 SGTC_2327 6189656 200 µM 0.368848035805164 0.346377931188868 no 1194 0.356120498902468 1791 5349088 SGTC_2343 7990716 14.84 µM 0.36820658182845 0.346633689835004 no 1195 0.356359601491239 1712 6456862 SGTC_1910 st062352 60.4 µM 0.366969243642189 0.347127235117499 no 1196 0.356820979970386 1580 2245730 SGTC_2233 sulbentine 40.3845 µM 0.365917435032718 0.347546981012129 no 1197 0.357213343002283 1662 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58 SGTC_208 k072-0098 12.366 µM 0.365128232347977 0.347862051425048 no 1198 0.357507843634351 1688 5948901 SGTC_1874 staurosporine 7.6 µM 0.362718090180968 0.348824893074887 no 1199 0.35840774236759 1745 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1 SGTC_1652 st011932 78 µM 0.361244478473528 0.349414075187268 no 1200 0.358958347422462 1762 1551076 SGTC_2194 5927483 104.545 µM 0.360510046005143 0.349707852950331 no 1201 0.359232872687559 1716 760979 SGTC_1024 4507-0395 26 µM 0.35845565134574 0.350530101767917 no 1202 0.360001175443032 1704 4201836 SGTC_67 0335-0847 266 µM 0.358132131039066 0.350659651174486 no 1203 0.360122217261192 1894 4552207 YOR254C SEC63 SGTC_75 0159-0059 199.013 µM 0.35803633286427 0.350698015613884 no 1204 0.360158061861635 1801 5377270 SGTC_1296 1068-0102 11.9 µM 0.356030246883336 0.351501745136058 no 1205 0.360908956813973 1761 767053 SGTC_304 1310-0298 97 µM 0.354025067780618 0.352305775327804 no 1206 0.361660048451831 1687 1550234 SGTC_2707 st078556 66.6 µM 0.354001505243078 0.352315227290839 no 1207 0.361668877584829 1817 17250899 SGTC_3213 9129884 49.47 µM 0.353185849395213 0.352642478674814 no 1208 0.36197455786178 1571 17190742 SGTC_108 0509-0257 621.132 µM 0.351817115177149 0.353191877066055 no 1209 0.362487711050583 1789 536624 SGTC_591 4299-0174 154 µM 0.351054113093185 0.353498272646091 no 1210 0.362773876092108 1730 5509088 SGTC_1533 dihydroergotamine mesylate 29.4 µM 0.350583992843369 0.353687104174081 no 1211 0.362950233553763 1748 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release. SGTC_1660 st012960 28.1 µM 0.35038075617568 0.353768748673704 no 1212 0.363026483268056 1702 24207266 SGTC_2415 st077333 57.7 µM 0.350332062967104 0.353788310771988 no 1213 0.363044752644248 1914 2766255 SGTC_1015 4130-4525 82 µM 0.347372263309004 0.354978109254281 no 1214 0.364155834086477 1651 1363237 SGTC_1288 0973-0013 65.5 µM 0.347332796765202 0.35499398384759 no 1215 0.364170657203117 1740 4315430 SGTC_2235 salicylic acid 500 µM 0.347018257139778 0.355120509840791 no 1216 0.364288801425661 1747 338 A COX inhibitor and kinase inhibitor. SGTC_2663 amphotericin b 100 µM 0.346589609767299 0.355292962275222 no 1217 0.364449826417424 1715 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_493 zm226600 134 µM 0.344308267935876 0.356211284388161 no 1218 0.365307233541049 1743 5240098 A potassium channel opener. YCR052W RSC6 SGTC_3087 9117406 49.47 µM 0.343013672952774 0.356732776963213 no 1219 0.365794086986662 1698 42546093 SGTC_2543 pimpinellin 60.67 µM 0.342894911174146 0.356780630363265 no 1220 0.365838760119664 1663 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo. SGTC_2643 anethole 100 µM 0.341896676349743 0.357182944172963 no 1221 0.366214325485924 1726 637563 An anti-fungal, anti-helmenthic and channel blocker. SGTC_2451 5856223 45.7 µM 0.341133147632343 0.357490772734039 no 1222 0.36650167404332 1671 2179896 SGTC_2083 5306046 65.942 µM 0.339236368503084 0.358255889946057 no 1223 0.367215836902903 1696 539837 SGTC_715 0868-0130 184 µM 0.338284977934307 0.358639873758909 no 1224 0.367574221501496 1868 2876258 SGTC_1047 2043-3044 82 µM 0.336590662815532 0.359324057672554 no 1225 0.368212747950286 1652 669592 SGTC_3355 9151058 44.0485 µM 0.335541685172726 0.359747873254812 no 1226 0.368608252576702 1743 17015728 SGTC_2761 levamisole 97.89 µM 0.335497728104194 0.359765636879434 no 1227 0.36862482911222 1840 26879 An alkaline phosphatase inhibitor. SGTC_2808 7946468 45.46 µM 0.335229417201591 0.35987407138087 no 1228 0.36872601643638 1757 2970879 SGTC_660 4031-1742 102 µM 0.334135227200604 0.360316391311375 no 1229 0.369138759359715 1716 6738706 SGTC_1882 5615643 20 µM 0.333517424837844 0.360566216966719 no 1230 0.369371869267516 1741 2253075 SGTC_2031 5180455 200 µM 0.331275248681827 0.361473402937624 no 1231 0.370218292737234 1719 29949 SGTC_938 3126-1755 342 µM 0.328412913404609 0.362632637735407 no 1232 0.371299740241849 1862 1777771 SGTC_3037 9091026 49.47 µM 0.327171652198976 0.363135736179016 no 1233 0.371769030170489 1774 25236398 YIL048W NEO1 SGTC_2623 humulene 100 µM 0.326759408184563 0.363302876054204 no 1234 0.371924931557609 1697 6187145 An anti-inflammatory. SGTC_1944 st076371 56.9 µM 0.326547358545577 0.363388859426407 no 1235 0.372005132129216 1678 24208455 SGTC_3329 9141233 27.5565 µM 0.326374111704445 0.363459113877963 no 1236 0.37207066098322 1825 4909101 YNL103W MET4 SGTC_869 0564-0080 44.1 µM 0.326072676904291 0.363581361606879 no 1237 0.372184684458778 1704 6843321 SGTC_1370 2001-0092 44.6 µM 0.324633667179439 0.364165147295131 no 1238 0.372729171700706 1873 790957 SGTC_732 3970-1727 52.7 µM 0.321802830569804 0.365314496471874 no 1239 0.373801034897227 1876 1275699 SGTC_1666 st014829 29 µM 0.321451634916776 0.365457170193735 no 1240 0.373934079297344 1723 3858230 SGTC_2355 9061122 103.12 µM 0.320910994062807 0.365676842679057 no 1241 0.374138921090399 1861 5302957 SGTC_2998 9066762 71.4286 µM 0.320040866021044 0.366030484456704 no 1242 0.374468675908505 1849 4945196 SGTC_1253 0550-0034 176 µM 0.31727738383924 0.367154386300925 no 1243 0.375516568306054 1751 5969915 SGTC_2942 9052777 62.25 µM 0.315942932841628 0.367697512975967 no 1244 0.376022911988153 1763 6469503 SGTC_2370 9071495 200 µM 0.315453153777692 0.367896921393541 no 1245 0.376208807217145 1724 21791103 SGTC_1740 st038286 13.222 µM 0.314374393561683 0.368336252838769 no 1246 0.376618350990932 1788 716786 SGTC_110 0850-0284 111.64 µM 0.314267934950031 0.368379618079719 no 1247 0.376658774796406 1766 3906265 SGTC_187 1488-2104 32.728 µM 0.314094172315374 0.368450402789611 no 1248 0.376724757774275 1830 2852859 SGTC_36 0335-0881 14.2 µM 0.312026363288939 0.369293096636983 no 1249 0.377510243923787 1784 23828853 SGTC_2001 4023502 57.655 µM 0.311126389247923 0.369660059427571 no 1250 0.3778522701561 1785 108941 YCR052W RSC6 SGTC_2746 daunorubicin 9.88 µM 0.310928561467869 0.369740739279241 no 1251 0.377927465497127 1877 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_2034 5197015 53.07 µM 0.310506106882205 0.369913047589638 no 1252 0.378088058106349 1879 780676 SGTC_3230 9131665 49.47 µM 0.310407048451463 0.369953454745637 no 1253 0.378125717397799 1782 15943720 SGTC_1778 st046819 58.9 µM 0.309905689133105 0.370157987410084 no 1254 0.378316338179266 1748 671715 SGTC_940 3232-1287 54.8 µM 0.308554407653934 0.370709433851408 no 1255 0.37883025347192 1900 1585493 YIL048W NEO1 SGTC_222 nsc-310342 10.666 µM 0.307681857657296 0.371065655314541 no 1256 0.37916221298118 1878 432556 SGTC_2605 digitonin 300 nM 0.306703694800078 0.371465124955539 no 1257 0.379534458601718 1921 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_1429 4049-0205 9.46 µM 0.306479975903555 0.371556508465676 no 1258 0.379619611847577 1790 22774478 SGTC_3343 9148379 18.9835 µM 0.300678912412042 0.373928609968803 no 1259 0.381829675275936 1895 1955036 SGTC_2980 9014342 25.29 µM 0.300001039981298 0.374206111249728 no 1260 0.382088181174914 1775 2996599 SGTC_2682 pyrogallin 40.03 µM 0.298695239894417 0.374740851504574 no 1261 0.382586294680023 1830 822798 An ATP competetive kinase inhibitor. SGTC_1092 toremifene 6.32 µM 0.295371186145463 0.376103175192366 no 1262 0.38385517100969 1813 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_2946 9065502 71.43 µM 0.295277886396489 0.376141435353395 no 1263 0.383890803953324 1792 16489101 SGTC_608 k048-0125 159 µM 0.295116374265608 0.376207670779233 no 1264 0.383952490819759 1895 6817652 YLR060W | YFL022C FRS1 | FRS2 SGTC_2294 7971431 200 µM 0.294704539489791 0.376376578936327 no 1265 0.384109797552475 1835 5741572 SGTC_1330 1469-0054 61.8 µM 0.294471901714435 0.37647200246735 no 1266 0.384198665629244 1933 7102664 SGTC_1769 st044406 64.4 µM 0.294416826180077 0.376494594495325 no 1267 0.384219705480535 1770 670903 SGTC_1875 nocodazole 6 µM 0.294363839167606 0.376516330209271 no 1268 0.38423994780066 1919 4122 A microtubule depolymerizer. YJL014W CCT3 SGTC_2418 pentamidine 31.67 µM 0.2889135798558 0.378754151685851 no 1269 0.386323755726613 1854 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_2688 kanamycin b 96.69 µM 0.288437403904219 0.37894985918023 no 1270 0.386505969781264 1769 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis. SGTC_947 3447-0010 211 µM 0.288293032313095 0.37900920178897 no 1271 0.386561220131872 1808 748350 SGTC_1138 3761-0006 1.03 µM 0.287863232578671 0.379185883876512 no 1272 0.3867257161429 1835 12061087 SGTC_2351 9026858 72.31 µM 0.28692044712165 0.379573532509593 no 1273 0.38708661694843 1723 1409300 SGTC_166 k072-0058 166.424 µM 0.286872495346583 0.379593252259819 no 1274 0.387104975628553 1926 5846229 SGTC_2914 7968218 45.32 µM 0.286794313562189 0.379625404509889 no 1275 0.387134908625535 1894 2977111 SGTC_1623 st003709 20.3 µM 0.286166449627683 0.379883643647491 no 1276 0.387375319497325 1749 16192618 SGTC_605 1315-0399 119 µM 0.285409388859497 0.380195092408791 no 1277 0.387665257641042 1854 24020461 SGTC_2573 2',4'-dihydroxychalcone 15.04 µM 0.284028423568242 0.380763410517142 no 1278 0.388194299197836 1876 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_2560 caryophyllene 100 µM 0.283369043412724 0.381034860610936 no 1279 0.388446978018794 1782 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor. SGTC_16 erodoxin 22.806 µM 0.282932127222374 0.38121476019282 no 1280 0.38861443319741 1838 3967339 Erodoxin inhibits Ero1. YML130C ERO1 SGTC_3129 9127257 49.47 µM 0.281815463325498 0.381674661438198 no 1281 0.389042506648088 1690 837894 SGTC_1793 st048256 72.231 µM 0.279760700965475 0.382521357403737 no 1282 0.389830552134103 1847 672022 SGTC_1362 1611-0397 101 µM 0.279613620115517 0.382581985894065 no 1283 0.389886978213223 1784 27816 SGTC_1472 k841-0093 193 µM 0.277289317636184 0.38354047243555 no 1284 0.390778980693371 1905 X1472 SGTC_1572 epiandrosterone 68.9 µM 0.275392325719884 0.384323275189215 no 1285 0.391507419710584 1861 441302 A steroid. SGTC_133 0724-0033 378.92 µM 0.274939007428698 0.384510409138529 no 1286 0.391681548970265 1880 280309 SGTC_1264 0783-0040 158 µM 0.273892167164531 0.384942657184466 no 1287 0.392083745601422 1750 2855798 SGTC_2361 9034121 116 µM 0.273868957795077 0.384952242126483 no 1288 0.392092663962895 1804 6496917 SGTC_805 3852-0218 479 µM 0.273570522239107 0.385075495489404 no 1289 0.392207344948108 1759 6615355 SGTC_22 0964-0034 14.468 µM 0.272562494591074 0.385491894929303 no 1290 0.392594772801035 1813 138402 SGTC_2140 5586273 200 µM 0.272170451711083 0.385653877001175 no 1291 0.392745480310442 1833 854421 SGTC_1371 2421-0008 32.7 µM 0.271649333865662 0.385869220411298 no 1292 0.392945831178228 1807 2827552 SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM 0.27142181507786 0.385963249857244 no 1293 0.393033312779442 1895 66535 A nucleotide analog. SGTC_681 1642-0006 26.6 µM 0.271067072946363 0.386109871801085 no 1294 0.393169722884015 1854 4446530 SGTC_2593 nobiletin 86.24 µM 0.269297064802622 0.386841693895625 no 1295 0.393850545364332 1775 72344 An anti-infammatory. SGTC_2425 5628681 7.85 µM 0.267202915142815 0.387708054230044 no 1296 0.394656465885208 1920 5714958 SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM 0.266569032065995 0.387970405354827 no 1297 0.394900500945771 1876 4000243 SGTC_709 3807-1509 243 µM 0.266332687475117 0.38806823659913 no 1298 0.394991500472453 1862 1886677 YPL242C IQG1 SGTC_2134 5324836 1.464 µM 0.263992743434149 0.389037203197394 no 1299 0.395892755183492 1854 699272 SGTC_1190 1486-1332 13 µM 0.263750825724544 0.38913742037317 no 1300 0.395985964243798 1843 4150046 SGTC_3056 9094900 49.47 µM 0.26329306898084 0.389327071512531 no 1301 0.396162350718399 1742 25236784 SGTC_2454 5-benzylidenerhodanine 10.36 µM 0.26256211709984 0.389629963547793 no 1302 0.396444050984019 1976 1273210 SGTC_1487 3970-0795 2.82 µM 0.262402317222962 0.389696190401305 no 1303 0.396505643186011 1886 3765103 SGTC_2263 7948595 193.29 µM 0.260431127917107 0.390513385473521 no 1304 0.397265617254789 1804 2971371 SGTC_399 oxolinic acid 75 µM 0.260043257664386 0.390674241760564 no 1305 0.397415203130322 1843 4628 A DNA gyrase inhibitor. SGTC_1712 st032288 53.4 µM 0.25997306514441 0.390703353773922 no 1306 0.397442275160466 1855 2883011 SGTC_2377 9073351 62.6 µM 0.257572462663542 0.391699359955266 no 1307 0.398368442184226 1798 7337946 YHR072W ERG7 SGTC_2846 9008642 19.48 µM 0.257437472224169 0.391755388429828 no 1308 0.398420539374531 1804 2992898 SGTC_897 1000-0139 31.4 µM 0.256035059445827 0.392337599669909 no 1309 0.398961882911244 1973 6151020 SGTC_3315 9136395 68.55 µM 0.255190766574881 0.392688223938774 no 1310 0.399287881123111 2000 16876844 SGTC_838 0109-0203 71.4 µM 0.254794389165616 0.392852864583215 no 1311 0.399440954541397 1859 759422 SGTC_69 0096-0274 206.684 µM 0.254326660679948 0.393047166505862 no 1312 0.399621602272264 1931 6741392 SGTC_3261 9137475 49.47 µM 0.253030908597658 0.393585581757511 no 1313 0.400122164289948 1907 17027690 SGTC_624 k048-0052 28 µM 0.250805407452023 0.394510803929525 no 1314 0.400982280318944 1877 6835531 SGTC_3094 9117742 49.47 µM 0.250744162848746 0.394536273991559 no 1315 0.401005957060705 1906 17149698 SGTC_967 1306-0166 352 µM 0.249492870473441 0.395056753005718 no 1316 0.401489777558636 1989 4437607 SGTC_2508 celastrol 40.54 µM 0.248096198224293 0.395637924426532 no 1317 0.402029988530356 1961 122724 Celastrol is a natural product and antioxidant. SGTC_215 1287-0124 461.5 µM 0.247647968687837 0.395824487167619 no 1318 0.402203396432214 2007 5560863 SGTC_2076 5212012 200 µM 0.247206537024013 0.396008243817256 no 1319 0.402374193235095 1906 604802 SGTC_1759 st043059 70 µM 0.247150109841817 0.396031734668884 no 1320 0.402396027137132 1792 669426 SGTC_2956 9076196 2.52 µM 0.24681042761371 0.396173153653412 no 1321 0.402527470018242 1978 16423868 SGTC_2321 7390090 138.78 µM 0.246319479248222 0.396377573002441 no 1322 0.402717466067689 1794 649046 SGTC_802 4112-3352 742 µM 0.245468274475939 0.396732062133115 no 1323 0.403046935066577 1970 704594 SGTC_2023 5144124 124 µM 0.24367358559606 0.397479750049514 no 1324 0.403741816221363 1860 2830192 SGTC_1519 esterone 74 µM 0.243388188486543 0.397598684547554 no 1325 0.403852346488511 1770 698 A steroid. SGTC_1094 duloxetine 25.4 µM 0.243341382173002 0.397618191209076 no 1326 0.403870474645349 1880 60834 A selective serotonin reuptake inhibitor. SGTC_2986 9022445 71.43 µM 0.242103221561315 0.39813429090583 no 1327 0.404350091002506 1995 6459286 SGTC_2234 tolnaftate 200 µM 0.242015454714893 0.398170881339295 no 1328 0.40438409400845 1974 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7 SGTC_575 k072-0246 11.9 µM 0.240484673229267 0.398809215475693 no 1329 0.40497727183908 1879 6796779 SGTC_352 k048-0007 5.11 µM 0.239801714090379 0.399094096110348 no 1330 0.405241989043649 1957 6811911 SGTC_439 amiodarone 34.4 µM 0.238786604362513 0.399517624975798 no 1331 0.405635528987124 1944 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1 SGTC_2539 epi(13)torulosol 80 µM 0.236381756228457 0.40052145819707 no 1332 0.406568225766474 1827 6708597 SGTC_3219 9131112 49.47 µM 0.235827838065679 0.400752768456996 no 1333 0.406783132830068 1974 17612988 YMR079W SEC14 SGTC_234 nsc-17383 10.7 µM 0.234242917333367 0.401414806285238 no 1334 0.407398199228819 1967 408974 SGTC_3351 9150312 21.596 µM 0.233715841976283 0.401635033951217 no 1335 0.407602794105326 1986 4904905 SGTC_327 1273-0057 3.96 µM 0.231173832836362 0.402697598037595 no 1336 0.408589878910779 1989 3108138 SGTC_331 k048-0133 24.5 µM 0.230457770497671 0.402997043457269 no 1337 0.408868037303047 1863 6813582 SGTC_1321 1326-2144 215 µM 0.230224627175671 0.40309455242383 no 1338 0.408958613034377 2000 3513030 SGTC_3274 9138298 49.47 µM 0.23006772852314 0.403160176505766 no 1339 0.40901957059569 2010 17015756 SGTC_2890 9046729 58.44 µM 0.228885295627481 0.403654825870897 no 1340 0.409479034804751 1829 903329 SGTC_2043 5101342 149 µM 0.228710451479491 0.40372798185096 no 1341 0.409546985490079 1923 678451 SGTC_515 4092-1064 102 µM 0.227453937834088 0.404253814627218 no 1342 0.410035391416953 2034 717353 SGTC_3336 9143619 71.43 µM 0.226902465989137 0.404484652303698 no 1343 0.410249792240999 1999 45595730 SGTC_3127 9126946 49.47 µM 0.224029899215796 0.40568760078424 no 1344 0.411367019123179 1828 27243249 SGTC_1594 piperine 70.1 µM 0.223623040049154 0.405858054036153 no 1345 0.411525317136013 1856 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_2117 5521686 200 µM 0.222738405377161 0.40622873242773 no 1346 0.411869554481782 1849 803312 SGTC_3191 9110352 49.47 µM 0.222358752291335 0.406387839936129 no 1347 0.412017309471906 1932 17122424 SGTC_1400 3771-8998 51.5 µM 0.221859623167297 0.406597041764007 no 1348 0.412211581627368 1958 670767 SGTC_2680 butyl paraben 22.24 µM 0.219425222322391 0.407617762216279 no 1349 0.41315941207939 2001 7184 An antifungal and steroid mimetic. SGTC_3049 9092223 49.47 µM 0.219147144303626 0.407734397669771 no 1350 0.41326771368354 1940 8623917 SGTC_2441 5730946 39.09 µM 0.218965130804627 0.407810744799673 no 1351 0.413338605111602 1976 1774275 SGTC_2353 9059630 146.67 µM 0.215912506693193 0.409091713829636 no 1352 0.414527974049357 1997 4779114 SGTC_2009 4012297 12.05 µM 0.214481438368955 0.409692566636275 no 1353 0.415085820106542 1889 45595307 SGTC_199 4063-0024 41.6 µM 0.213616302687019 0.410055908187912 no 1354 0.41542314256737 2010 306215 SGTC_3105 9121040 49.47 µM 0.21352109101204 0.410095900116158 no 1355 0.415460270078804 2064 41448907 SGTC_251 melphalan 456.522 µM 0.212930438463891 0.410344013829017 no 1356 0.415690610148099 1982 460612 A DNA alkylator. SGTC_736 0958-0254 92.6 µM 0.211807589788747 0.410815784523507 no 1357 0.416128573533834 1984 6812352 SGTC_2148 5546263 113.568 µM 0.211518804978005 0.410937139848853 no 1358 0.416241229949804 1932 792097 SGTC_3098 9119039 49.47 µM 0.211164017004552 0.411086243188643 no 1359 0.416379643953239 2010 17161528 SGTC_138 0850-0259 40.9225 µM 0.209930257423566 0.411604843372781 no 1360 0.416861053190816 2033 6813004 SGTC_2107 5363541 170.161 µM 0.209642742223299 0.411725720129402 no 1361 0.416973258690097 2029 244052 SGTC_3209 9113616 49.47 µM 0.209423049101214 0.411818088865576 no 1362 0.417059000547201 2099 16649353 SGTC_93 0109-0045 59.227 µM 0.20786201301808 0.412474558125207 no 1363 0.417668355261865 2060 88733 SGTC_3006 9075424 71.4286 µM 0.206242472664201 0.413155889296294 no 1364 0.41830075627182 1891 7465181 SGTC_698 k064-0052 127 µM 0.205813164005359 0.413336540897352 no 1365 0.418468428973212 1996 5088751 SGTC_2545 solidagenone 89.61 µM 0.20270044464009 0.414646908979048 no 1366 0.419684587809525 1980 6708572 An anti ulcer agent SGTC_911 3456-4043 236 µM 0.201779513975998 0.415034777959681 no 1367 0.420044548804548 1997 914281 SGTC_3033 9090887 49.47 µM 0.200292731451825 0.415661141800833 no 1368 0.420625823417845 1908 19325384 SGTC_63 0099-0242 26.702 µM 0.200215315440924 0.415693762132565 no 1369 0.420656094844351 2068 3898502 YLR359W ADE13 SGTC_2595 hexamethylquercetagetin 100 µM 0.199911784405517 0.415821664831886 no 1370 0.42077478692888 1950 386331 SGTC_177 1327-0068 8.361 µM 0.199664497147975 0.415925873974042 no 1371 0.420871490899287 2035 15389900 YOR207C | YLR033W RET1 | RSC58 SGTC_1041 0206-0046 107 µM 0.199569668807771 0.41596583708404 no 1372 0.420908575666143 1947 50494 SGTC_1916 st067606 49.2 µM 0.199511695606135 0.415990268915471 no 1373 0.420931247743337 2016 19590279 SGTC_3282 9108498 15.4605 µM 0.198841020559621 0.41627293722239 no 1374 0.421193553432264 1926 16459645 SGTC_414 piperonyl butoxide 100 µM 0.198176467333441 0.416553068096234 no 1375 0.421453499340193 1912 5794 A potent inhibitor of cytochrome P450. SGTC_2276 7947513 42.08 µM 0.19729280314015 0.41692562702325 no 1376 0.421799205464061 1793 2105100 SGTC_1999 st074831 12.5 µM 0.196708193190254 0.417172143649079 no 1377 0.422027949064492 1931 17112523 SGTC_200 k038-0079 37.545 µM 0.196253591646021 0.417363861220567 no 1378 0.422205841735452 1998 3436683 SGTC_614 0462-0418 107 µM 0.196238146771394 0.41737037508065 no 1379 0.422211885834639 2011 5188303 SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM 0.19312077123897 0.418685586853116 no 1380 0.423432192880084 2057 688798 SGTC_2274 7947094 46.08 µM 0.190299654948078 0.419876592097259 no 1381 0.424537162011186 2119 2971028 SGTC_2348 9022543 33.42 µM 0.190119586784986 0.419952637446768 no 1382 0.424607710981186 1977 3162678 YDL140C RPO21 SGTC_1334 1486-0610 236 µM 0.189589872802609 0.420176360522924 no 1383 0.424815261806573 2018 3742339 SGTC_417 st075190 100 µM 0.18665204135841 0.421417610920804 no 1384 0.425966730299144 2091 222757 SGTC_1958 st076513 41.9 µM 0.185426070284188 0.421935822400453 no 1385 0.426447430918713 1955 732122 YGL099W LSG1 SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM 0.18433904134004 0.422395416891052 no 1386 0.426873744061774 1938 279621 SGTC_2734 clemastine 41.6 µM 0.183604325020803 0.422706113932822 no 1387 0.427161934965139 2089 26987 Clemastine is a selective histamine H1 antagonist. SGTC_2939 9044578 71.43 µM 0.182031161119877 0.423371535408056 no 1388 0.427779135691625 1976 2653634 SGTC_2501 sodium tetradecyl sulfate 13.37 µM 0.181795450825264 0.423471255717347 no 1389 0.427871627374431 1891 23665772 A membrane-active detergent. SGTC_952 1185-0122 232 µM 0.180586833739398 0.423982653787017 no 1390 0.428345945559801 2036 678600 SGTC_1130 3454-2858 15.9 µM 0.180447836353171 0.424041475507516 no 1391 0.428400501322137 1897 715628 YIL048W NEO1 SGTC_1952 st077036 64.1 µM 0.179789256270489 0.424320200230838 no 1392 0.428659009216222 2123 2937007 SGTC_922 1866-0035 480 µM 0.179486840803934 0.424448201406371 no 1393 0.428777724533815 1950 3156169 SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM 0.178705470834418 0.424778963000934 no 1394 0.429084486617644 2040 688761 SGTC_1518 st038567 90.8 µM 0.178125752305727 0.425024397798212 no 1395 0.429312109009156 2088 77966 SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM 0.177954672184915 0.425096833359616 no 1396 0.429379286907286 2002 6312947 SGTC_2551 apiole 73.87 µM 0.17795308625812 0.425097504855063 no 1397 0.429379909661499 2076 10659 A possible DNA adduct former. SGTC_1269 0831-0796 3.05 µM 0.177876559254793 0.425129907324068 no 1398 0.429409960131086 2080 927758 SGTC_1443 4112-3303 14 µM 0.177191656206369 0.425419926144535 no 1399 0.429678924674288 1990 704433 SGTC_836 0330-0104 1.35 µM 0.176319109411361 0.425789460224937 no 1400 0.430021625037685 2094 46494820 SGTC_1354 1498-1681 81 µM 0.176245104096738 0.425820805370661 no 1401 0.430050693699661 1980 5754243 SGTC_862 0452-0056 10.2 µM 0.175041499986896 0.42633066072463 no 1402 0.430523512336293 2071 1575396 YLR359W | YHR072W ADE13 | ERG7 SGTC_1048 3161-0300 24.5 µM 0.173695232185517 0.426901095319745 no 1403 0.43105249236665 2062 2165101 SGTC_428 3448-4153 16.5 µM 0.173579476732857 0.426950149860198 no 1404 0.43109798117384 1867 3834874 SGTC_2054 5233173 129 µM 0.173346232193632 0.427048997046805 no 1405 0.431189642835867 2009 6889 SGTC_277 nystatin 15.5 µM 0.170171147498219 0.428395025837519 no 1406 0.432437770853701 2028 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_3242 9133940 49.47 µM 0.169889414524163 0.428514502727451 no 1407 0.432548553045459 2064 17248444 SGTC_1292 0kpi-0043 232 µM 0.168831464141822 0.428963215122498 no 1408 0.432964604381258 1989 3333905 SGTC_1971 st069429 63.5 µM 0.168784088652825 0.428983310815543 no 1409 0.432983237087175 2116 1246522 YGL099W LSG1 SGTC_1182 1222-0449 220 µM 0.168134494107514 0.429258873800589 no 1410 0.43323873661845 2047 658318 SGTC_2905 7799065 20.05 µM 0.167879720525383 0.429366960127162 no 1411 0.433338952182621 2110 1296806 SGTC_262 fenpropimorph 62.5 µM 0.16711290102511 0.429692311113581 no 1412 0.433640607604104 2084 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_1897 st060201 15 µM 0.166761749398502 0.429841315882855 no 1413 0.433778758362547 1936 611878 SGTC_1074 carmofur 3.8 µM 0.164506047352326 0.430798719181461 no 1414 0.434666393252627 2116 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_1761 st044296 37 µM 0.163466564869238 0.431240051242569 no 1415 0.435075548198292 2047 1826700 SGTC_2937 9044753 11.33 µM 0.16338684477371 0.431273901477493 no 1416 0.435106930026825 2067 6465530 YGL099W LSG1 SGTC_1933 st074711 15.9 µM 0.162823252574406 0.431513224761985 no 1417 0.43532879983597 2131 17250958 SGTC_2226 7298446 200 µM 0.161793663460194 0.431950493416842 no 1418 0.435734171562493 2126 3283010 SGTC_3229 9132204 49.47 µM 0.161365272442823 0.432132456575208 no 1419 0.435902858383837 2041 17682924 SGTC_457 grayanotoxin iii 135 µM 0.160296177627314 0.432586627483494 no 1420 0.436323884877473 2047 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity. SGTC_731 3966-0296 387 µM 0.158563761260822 0.433322778320255 no 1421 0.437006290915208 2051 660956 SGTC_127 0180-0333 59.125 µM 0.158473859489788 0.433360986365817 no 1422 0.437041708732299 2132 771601 SGTC_3133 9127736 49.47 µM 0.158400138207928 0.433392318205554 no 1423 0.437070752439672 2160 27243420 SGTC_2201 6605497 169.863 µM 0.157204662793058 0.433900458338714 no 1424 0.43754177680884 2094 670741 SGTC_3101 9120531 49.47 µM 0.157164992371839 0.433917322238551 no 1425 0.437557408710186 2130 24824904 SGTC_2712 st079126 47.7 µM 0.156982171470271 0.433995040975191 no 1426 0.437629449494254 2042 3152970 SGTC_2053 5265679 138 µM 0.156687550605076 0.434120292205368 no 1427 0.437745549530799 2045 764595 SGTC_3152 9099253 49.47 µM 0.154805757295605 0.434920448520532 no 1428 0.438487226132873 2077 25236131 SGTC_1814 st052110 31.539 µM 0.154329054758164 0.435123189400928 no 1429 0.438675144678533 2127 674163 SGTC_112 phenothiazine 287.218 µM 0.15423903028278 0.43516147859283 no 1430 0.438710634334246 2146 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.  SGTC_2773 thioridazine 9.09 µM 0.151175854396368 0.436464667926193 no 1431 0.43991849838523 2174 5452 An antipsychotic. SGTC_171 k064-0041 9.68 µM 0.150656440600394 0.436685714739899 no 1432 0.440123368148119 2001 53325 SGTC_2825 7998094 58.44 µM 0.150597929863758 0.436710616381395 no 1433 0.440146447248482 2057 2987815 SGTC_1303 1160-0052 261 µM 0.150035030203549 0.436950194195025 no 1434 0.440368488974808 2154 3562476 SGTC_1412 3909-8563 178 µM 0.149913285251974 0.437002013560372 no 1435 0.440416515027967 2157 23767530 SGTC_2781 5567276 71.43 µM 0.149867277811089 0.437021596390077 no 1436 0.440434664311047 2086 2853274 SGTC_3091 9116372 49.47 µM 0.148697217049717 0.437519678449254 no 1437 0.440896278648737 2066 17169793 SGTC_813 k007-0158 173 µM 0.148182787638027 0.437738696806242 no 1438 0.441099257661206 2116 6523916 SGTC_1950 st077106 7.18 µM 0.147471056485893 0.438041747833423 no 1439 0.441380111753927 1990 13831864 SGTC_441 propafenone 146 µM 0.147259388583893 0.438131881826475 no 1440 0.441463643082751 2100 4932 Slows the influx of sodium ions into the cardiac muscle. SGTC_1559 coumarin 343 70.1 µM 0.145044433096921 0.439075262222472 no 1441 0.442337895081622 2117 108770 A hepatotoxic, DNA x-linker. SGTC_2231 micatex 6.853 µM 0.144804553422085 0.439177451187777 no 1442 0.442432593505132 2081 20737 An antifungal of unknown mechanism. SGTC_843 0310-0051 143 µM 0.143976264023179 0.439530334366532 no 1443 0.44275960644862 2042 2065037 SGTC_1008 4106-0037 6 µM 0.143743234227156 0.439629622706493 no 1444 0.442851614857725 2077 2905394 SGTC_2878 9043973 25.97 µM 0.140773252194788 0.440895390478547 no 1445 0.444024537132906 2136 6465167 SGTC_1907 st060210 83.7 µM 0.139350484518109 0.441501970387236 no 1446 0.444586599064468 2135 688793 SGTC_1520 flindersine 88 µM 0.1384373667975 0.441891339548212 no 1447 0.444947383439916 2161 68230 Flindersine is a natural alkaloid of the quinoline subtype. SGTC_176 1486-1328 72.834 µM 0.138313081807761 0.441944341163701 no 1448 0.444996493546369 2041 22310231 SGTC_3304 9125678 46.087 µM 0.137448452264873 0.442313093107731 no 1449 0.445338167532111 2064 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2 SGTC_2662 daunorubicin 22.37 µM 0.136667836424907 0.442646057375745 no 1450 0.445646676872908 2137 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_1477 0139-0234 16 µM 0.135102606565546 0.443313813127097 no 1451 0.446265374666957 2173 620880 SGTC_1327 1436-0082 2.18 µM 0.134815336834537 0.443436385203885 no 1452 0.446378939751548 2047 15992205 SGTC_2785 7756463 72.73 µM 0.134748852480457 0.443464753479927 no 1453 0.446405223347147 2089 2201551 SGTC_2788 5282734 71.43 µM 0.134530338843096 0.443557993324432 no 1454 0.446491611105549 2146 743706 SGTC_1921 5740136 50 µM 0.13356529158006 0.443969816630665 no 1455 0.446873165758179 2181 1774243 SGTC_2268 7933382 153.85 µM 0.133423007836224 0.444030539782579 no 1456 0.446929425228145 2183 935025 YOR257W CDC31 SGTC_3238 9133470 49.47 µM 0.132394684000076 0.444469441717193 no 1457 0.447336059609163 2182 3534688 SGTC_2312 7706453 155.7 µM 0.13179962371806 0.444723452294804 no 1458 0.447571392092749 2063 976098 SGTC_2369 9071472 200 µM 0.131513321003205 0.444845673080277 no 1459 0.447684624730628 2097 17296037 SGTC_134 0269-0018 6.916 µM 0.130311841455925 0.445358634005028 no 1460 0.448159855914296 2048 4378915 SGTC_2114 5491910 81.25 µM 0.130213287474704 0.445400714816042 no 1461 0.448198841100354 2144 2849228 SGTC_2170 morpholine 200 µM 0.129487713891781 0.445710540839049 no 1462 0.448485873000491 2138 121171 Reacts with secondary amines. SGTC_2365 9042475 200 µM 0.129129497262186 0.445863514590193 no 1463 0.448627590979266 2056 6464479 SGTC_3214 9129694 49.47 µM 0.128887623486949 0.445966809548846 no 1464 0.448723285004114 2161 17158655 SGTC_2873 9040596 71.43 µM 0.128184153884448 0.446267255097464 no 1465 0.449001619990658 2006 6463863 SGTC_497 capsazepine 133 µM 0.127493725058672 0.446562161047526 no 1466 0.449274819666511 2052 2733484 A calcium channel blocker. SGTC_2245 6637752 200 µM 0.127145139151941 0.446711065342547 no 1467 0.449412762734192 2174 681890 SGTC_747 3448-8087 38.7 µM 0.127042303458272 0.446754994763682 no 1468 0.449453458236046 2073 5168703 SGTC_1629 st005085 44.9 µM 0.125763962514079 0.447301131686163 no 1469 0.449959384483494 2063 24207091 SGTC_151 3013-0144 2.285 µM 0.125211280500179 0.447537281275532 no 1470 0.450178143490386 2186 906558 YHR107C CDC12 SGTC_934 2950-0684 338 µM 0.124634193775245 0.447783878340009 no 1471 0.450406578367129 2203 1121253 SGTC_2413 inermin 26.06 µM 0.124633558855492 0.447784149661051 no 1472 0.450406829703781 2182 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1 SGTC_2796 7949634 45.45 µM 0.123438840785558 0.448294733144006 no 1473 0.450879800871574 2129 2971588 SGTC_1322 1348-1070 12 µM 0.123081883114142 0.448447301853667 no 1474 0.451021128685083 2177 6758089 SGTC_3171 9103192 49.47 µM 0.122954190403699 0.448501881359939 no 1475 0.451071686696878 2205 13018434 SGTC_2172 5754775 163.918 µM 0.12231047807898 0.448777037187682 no 1476 0.45132656699878 2075 2263357 SGTC_636 0kpi-0074 126 µM 0.122150316384268 0.448845502384631 no 1477 0.451389986742469 2083 616434 SGTC_1284 0929-0043 16 µM 0.121654419631431 0.449057495737158 no 1478 0.451586356442755 2086 1239883 SGTC_1972 st070201 17.4 µM 0.121031080546633 0.449323990665122 no 1479 0.451833208714459 2199 2829099 SGTC_2092 5303694 80.6725 µM 0.120638283381769 0.449491934210659 no 1480 0.451988772261218 2077 1963699 SGTC_481 bay k-8644 50 µM 0.120308046642436 0.449633136552132 no 1481 0.452119565057048 2059 2303 A calcium channel antagonist. SGTC_3296 9122258 64.045 µM 0.119572053549472 0.449947854767031 no 1482 0.452411079447322 2098 4730474 SGTC_852 0418-0143 439 µM 0.11952713524151 0.44996706331874 no 1483 0.452428871660067 2210 5369229 SGTC_2913 7966556 36.57 µM 0.119322782645307 0.450054452715755 no 1484 0.452509817251582 2184 2976516 SGTC_695 3505-6186 243 µM 0.119188089543146 0.450112054233289 no 1485 0.452563171276031 2150 1819379 SGTC_3183 9108214 49.47 µM 0.119095327886241 0.450151724375619 no 1486 0.452599916103535 2188 4974831 SGTC_2109 5483026 200 µM 0.117687774364661 0.450753734936176 no 1487 0.453157527050193 2087 759335 SGTC_2466 5983409 37.09 µM 0.117441096331899 0.450859250824741 no 1488 0.453255259607522 2082 2879657 SGTC_556 4058-0063 51.5 µM 0.116431377054575 0.451291191747959 no 1489 0.453655334600159 2099 6615692 SGTC_326 k292-0812 17.5 µM 0.115864041480267 0.451533913706089 no 1490 0.453880147225469 2199 3579357 SGTC_2490 carminic acid 95.39 µM 0.115222942788181 0.451808215382691 no 1491 0.454134207035406 2178 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_3194 9111903 49.47 µM 0.114955793046583 0.451922525366115 no 1492 0.454240080856043 2157 17087251 SGTC_2830 7992007 71.43 µM 0.114034056935735 0.452316955090312 no 1493 0.454605397997378 2085 1952075 SGTC_1680 diphenhydramine 100 µM 0.113981339948395 0.452339515193359 no 1494 0.454626292797563 2052 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1 SGTC_2899 9053889 58.44 µM 0.113535140711954 0.45253047119793 no 1495 0.45480315246181 2227 6470052 SGTC_2284 7945075 39.21 µM 0.11258112937528 0.452938787907805 no 1496 0.455181323249585 2214 1245402 SGTC_3342 9147791 14.508 µM 0.112342392322335 0.45304097513278 no 1497 0.455275965158526 2195 1838168 SGTC_1895 st058434 18.3 µM 0.112194710868034 0.453104189156706 no 1498 0.455334511404442 2224 5393175 SGTC_2973 9094665 17.96 µM 0.110540425125793 0.453812375561276 no 1499 0.455990395838317 2196 25237061 YIL048W NEO1 SGTC_2190 6049624 200 µM 0.110318056771609 0.453907580911503 no 1500 0.456078568716846 2182 2265554 SGTC_2075 5212009 200 µM 0.110227745966329 0.453946247564951 no 1501 0.456114379122902 2204 780898 SGTC_139 0099-0334 718.624 µM 0.110059897630068 0.454018113142117 no 1502 0.456180935971341 2228 97690 SGTC_2588 indole-3-carbinol 100 µM 0.109635216035666 0.454199950604408 no 1503 0.456349340318338 2206 3712 Induces cell cycle arrest. SGTC_3057 9095946 49.47 µM 0.109080162050601 0.454437624554248 no 1504 0.456569454689776 2226 24540043 SGTC_2638 epoxomicin 18 µM 0.107422142534514 0.455147684833721 no 1505 0.457227044470984 2210 9915668 A protesome inhibitor. SGTC_1540 guanosine 70.6 µM 0.106214998879496 0.455664744164665 no 1506 0.457705885439736 2195 6802 Guanosine is a purine nucleoside SGTC_478 N-arachidonylglycine 10 µM 0.104806552208699 0.456268123071883 no 1507 0.458264655388275 2223 5283389 SGTC_1771 st048882 4.1505 µM 0.103856932585638 0.456674997368313 no 1508 0.458641442516377 2085 4580403 SGTC_710 3448-4187 58 µM 0.103791787468949 0.456702911133608 no 1509 0.458667291959643 2186 3946412 SGTC_1223 0764-0573 147 µM 0.102760250530624 0.457144938573795 no 1510 0.459076626839037 2197 1609797 SGTC_1913 st060213 96.1 µM 0.101327447038207 0.457759001985891 no 1511 0.459645264366518 2215 688959 SGTC_2651 TUB2.036 5 µM 0.0999970478243643 0.458329267834386 no 1512 0.460173334596783 2222 15992207 YFL037W TUB2 SGTC_1282 0886-0010 32.4 µM 0.0987114846942982 0.458880396532602 no 1513 0.460683674968356 2222 2836211 YNL267W PIK1 SGTC_43 0570-0105 72.5 µM 0.0985905585321907 0.458932242394339 no 1514 0.460731683348546 2191 1114046 YDL195W SEC31 SGTC_2400 5203494 178.7 µM 0.0964932419644348 0.459831555897266 no 1515 0.461564420506601 2239 6777674 SGTC_2932 9016711 44.54 µM 0.095982124667715 0.460050750459332 no 1516 0.461767384728663 2239 7117328 SGTC_2622 2-methoxyxanthone 59.94 µM 0.0954501799686278 0.460278889823826 no 1517 0.461978630067024 2201 71034 A hepatoprotective. SGTC_2604 4'-hydroxychalcone 11.32 µM 0.095348918614552 0.460322320072028 no 1518 0.462018844090122 2136 5282362 SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM 0.0925141954710575 0.461538302152578 no 1519 0.463144756617174 2177 115019 SGTC_2881 9058953 51.95 µM 0.0919841872039653 0.46176569460591 no 1520 0.463355301553222 2223 17122249 SGTC_3116 9124943 49.47 µM 0.0912040608665748 0.462100419351104 no 1521 0.463665224149678 2126 41905195 YPL160W CDC60 SGTC_27 0485-0001 32.618 µM 0.0909467737077595 0.462210818110574 no 1522 0.463767442059863 2241 2054479 SGTC_550 4123-0385 25.7 µM 0.0907113416159908 0.462311841680328 no 1523 0.463860979241317 2174 5731123 SGTC_1876 myriocin 605 nM 0.0888447611287561 0.463112874186006 no 1524 0.464602642041718 2258 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1 SGTC_2357 9067248 200 µM 0.0883149892936459 0.463340250180735 no 1525 0.464813162886246 2160 9150235 SGTC_2450 5739737 12.93 µM 0.0876570836890379 0.463622637350693 no 1526 0.46507461526021 2156 2262825 SGTC_921 1561-0023 372 µM 0.085460786880624 0.464565466888177 no 1527 0.465947534458187 2277 24050882 SGTC_2058 5236698 133 µM 0.0849451465643427 0.464786850764332 no 1528 0.466152499849901 2208 766665 SGTC_680 0417-1641 114 µM 0.0848064769775763 0.464846388721662 no 1529 0.466207622105312 2183 2835990 SGTC_948 3448-0295 75.3 µM 0.0846644602052781 0.464907364612964 no 1530 0.466264075565292 2253 678569 SGTC_2838 9002687 71.43 µM 0.0826931996791942 0.465753823536413 no 1531 0.46704774611184 2150 6457060 SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM 0.0812268339329604 0.466383581450193 no 1532 0.467630779813969 2229 364106 SGTC_362 0310-0100 9.03 µM 0.0808787684499301 0.466533077035421 no 1533 0.467769182481241 2190 790235 SGTC_376 3970-0862 59.1 µM 0.0796244720003696 0.467071841638324 no 1534 0.468267965583678 2268 3135186 SGTC_294 k038-0071 157 µM 0.0794812043112378 0.467133384026126 no 1535 0.46832494054927 2185 24152826 SGTC_2649 anisomycin 9.56 µM 0.0794570049195951 0.467143779248332 no 1536 0.46833456427319 2197 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_2337 9009472 200 µM 0.0788926014276034 0.467386233821503 no 1537 0.468559024052845 2245 5742383 SGTC_1659 st012954 42.1 µM 0.0784857045502669 0.467561034739049 no 1538 0.468720850629807 2225 24207262 SGTC_1750 st081859 2.357 µM 0.0776179597986082 0.467933834512809 no 1539 0.469065977813632 2207 5291695 SGTC_2328 6201408 200 µM 0.0771841693339648 0.468120209773468 no 1540 0.469238517558292 2192 2890418 SGTC_786 4544-0069 423 µM 0.0771386183053792 0.468139780883684 no 1541 0.469256635772303 2199 748821 YLR208W SEC13 SGTC_2135 5326629 150.42 µM 0.0768727424693982 0.468254016618187 no 1542 0.469362390861783 2193 5020077 SGTC_1671 st016596 74.5 µM 0.0768118402497398 0.468280184124893 no 1543 0.469386615705815 2260 2829167 SGTC_652 0437-0092 114 µM 0.0765425717654617 0.468395880807946 no 1544 0.469493722962519 2256 3091274 SGTC_602 3130-1533 38.1 µM 0.076343594411674 0.468481377192154 no 1545 0.469572871848454 2257 720941 SGTC_1247 0448-0043 5.84 µM 0.0757526570986978 0.468735299081566 no 1546 0.469807941000758 2188 3089013 YGL099W LSG1 SGTC_1 0258-0098 57.368 µM 0.0755782379498027 0.468810248282025 no 1547 0.469877325267632 2171 6790032 YDR047W HEM12 SGTC_1347 1493-0251 600 nM 0.0750883524220225 0.469020761626281 no 1548 0.470072207541249 2266 3986378 SGTC_1620 st003704 16.5 µM 0.075006544125684 0.469055917088713 no 1549 0.470104752551678 2255 2834414 SGTC_770 0389-1121 67.2 µM 0.0748207714520818 0.469135750037256 no 1550 0.470178657455154 2249 6753108 SGTC_800 3448-7362 155 µM 0.0741748987817686 0.469413313517469 no 1551 0.47043560934424 2278 15991913 SGTC_3104 9120930 49.47 µM 0.0729339146291529 0.469946667485307 no 1552 0.470929352914007 2187 17014836 SGTC_1399 3562-5772 25 µM 0.0728544605644312 0.469980817343403 no 1553 0.470960966397982 2267 23847490 SGTC_3268 9137683 49.47 µM 0.0728304213529145 0.469991149591637 no 1554 0.470970531246508 2193 1953228 SGTC_1363 1636-0063 10.4 µM 0.0722384337038082 0.47024559704643 no 1555 0.471206079691225 2269 6072185 SGTC_663 1486-0733 13.9 µM 0.071372522572132 0.470617803833695 no 1556 0.471550638817976 2209 722445 YPR165W RHO1 SGTC_2723 salbutamol 83.58 µM 0.0697992165357186 0.471294145611778 no 1557 0.472176735386303 2269 9884233 β2-adrenoceptor agonist SGTC_734 2023-0417 80 µM 0.0697450142404445 0.471317447890405 no 1558 0.472198306404172 2253 3935732 SGTC_2452 5863136 48.41 µM 0.0697096211573083 0.471332663894695 no 1559 0.472212391918642 2266 2184096 SGTC_2885 9057732 51.95 µM 0.0685866924937969 0.471815448965524 no 1560 0.472659305886429 2217 6471414 SGTC_1525 8-methoxypsoralen 92.5 µM 0.0672769802669731 0.472378590892079 no 1561 0.473180601223194 2302 4114 Related to psoralen; DNA damaging agent. SGTC_279 1273-0055 2.93 µM 0.0670557432585734 0.472473722488872 no 1562 0.473268663157667 2288 2847562 SGTC_1301 naphtanilide LB 4.81 µM 0.0669937230082913 0.472500391389707 no 1563 0.473293350144561 2281 67238 An a1-adrenergic receptor antagonist or alpha blocker. SGTC_1991 st073000 8.92 µM 0.0638400876426495 0.473856624320769 no 1564 0.474548779010617 2267 4301969 YIL048W NEO1 SGTC_1558 st069300 45.6 µM 0.0634185861875565 0.474037915935094 no 1565 0.47471659370194 2295 24208000 SGTC_1889 st059080 5.18 µM 0.0634026576435262 0.474044767052606 no 1566 0.474722935508886 2293 176925 Isolated from Daphnopsis sellowiana. SGTC_2779 methotrexate 400 µM 0.0629980380175175 0.474218802891336 no 1567 0.474884033327378 2296 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2 SGTC_2749 bexarotene 57.39 µM 0.0627659548945251 0.474318629191553 no 1568 0.474976438225579 2219 82146 An retinoic acid receptor inhibitor. SGTC_2439 5492030 7.2 µM 0.0627494715176545 0.474325719275302 no 1569 0.474983001204556 2298 5722370 SGTC_2521 angolensin 13.4 µM 0.0626318742503704 0.474376302257617 no 1570 0.475029823627167 2230 821428 A flavenoid. SGTC_1231 0242-0792 125 µM 0.0616757527533527 0.47478758112914 no 1571 0.475410524849636 2253 3707635 SGTC_1488 4013-0813 75.9 µM 0.0609616087488381 0.475094790123497 no 1572 0.475694891971026 2232 2910057 SGTC_540 1187-0821 17.3 µM 0.0608030327067616 0.475163008053585 no 1573 0.475758037520842 2220 847520 SGTC_2367 9070478 135.38 µM 0.0578859269584426 0.476418047493215 no 1574 0.476919746492631 2294 572802 SGTC_2258 7960471 200 µM 0.0576774481455869 0.476507751369917 no 1575 0.477002778778818 2162 2974708 SGTC_388 3',4'-dichloroisocoumarin 16.7 µM 0.0566401444699922 0.476954098079393 no 1576 0.477415927597549 2239 1609 A potent and irreversible inhibitor of serine proteases. SGTC_3201 9113999 49.47 µM 0.0563959361479315 0.47705918395422 no 1577 0.477513197144561 2276 16649224 SGTC_683 panaxydol 45 µM 0.0563527674076424 0.477077760165594 no 1578 0.477530391635905 2285 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis. SGTC_915 methyl methanesulfonate (MMS) 110 mM 0.0562036351828574 0.477141934571553 no 1579 0.477589792642662 2241 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks. SGTC_14 0354-0009 295 µM 0.0558858107429787 0.477278702391552 no 1580 0.477716387275174 2304 1713507 SGTC_2064 5220758 200 µM 0.0538702672559258 0.478146102891583 no 1581 0.47851926277417 2250 788518 SGTC_3254 9136651 49.47 µM 0.0536981373896383 0.478220184806054 no 1582 0.478587833405191 2323 16454030 SGTC_1020 4335-0961 93.3 µM 0.053215265689949 0.478428008995385 no 1583 0.478780196293975 2215 669075 SGTC_1522 st012842 45.6 µM 0.0532014186492495 0.478433968739798 no 1584 0.478785712649685 2309 3491067 YOR116C RPO31 SGTC_1970 st070122 35.8 µM 0.0530751897087265 0.478488297698298 no 1585 0.478835999663693 2283 102928 SGTC_1689 st020265 53.493 µM 0.0527889822771155 0.478611482906954 no 1586 0.478950020065296 2315 5758320 YPR016C TIF6 SGTC_1752 st044819 83.042 µM 0.0525935264626917 0.478695609309255 no 1587 0.479027887484117 2263 441209 YML126C ERG13 SGTC_3208 9114115 49.47 µM 0.0525048345266791 0.478733783639078 no 1588 0.479063221627476 2183 650895 SGTC_373 0844-0104 25.9 µM 0.0523921647009456 0.478782278690943 no 1589 0.479108108603625 2321 5375804 SGTC_1707 st032323 6.317 µM 0.0507647219143234 0.47948279304023 no 1590 0.479756501223759 2264 3132057 YMR211W DML1 SGTC_1675 st018485 24.5 µM 0.0492677042044193 0.480127223403338 no 1591 0.48035297828039 2194 3323024 SGTC_2027 5150920 200 µM 0.0472071916805421 0.48101430943201 no 1592 0.481174047891001 2291 786715 SGTC_1926 methyl fluorone black 53.6 µM 0.0468481608644004 0.481168888106752 no 1593 0.481317122163554 2318 72721 Reacts with homocysteine. SGTC_2432 5630864 12.22 µM 0.0458952838546886 0.481579157548183 no 1594 0.481696856578425 2279 5714970 SGTC_2705 st078069 42.8 µM 0.0454806866219196 0.481757672090894 no 1595 0.481862084405088 2282 1530061 SGTC_153 4077-0274 519.67 µM 0.0453161478130415 0.481828519142159 no 1596 0.481927658283397 2337 3121976 SGTC_2038 4100038 30.985 µM 0.0442851642961206 0.482272452566405 no 1597 0.482338548624787 2282 3596803 SGTC_1628 st004252 77.7 µM 0.043022189854713 0.482816309366219 no 1598 0.482841922640819 2317 692968 SGTC_2279 7948423 32.93 µM 0.0424141474450852 0.483078153524473 no 1599 0.483084275234068 2323 1247112 SGTC_2841 9004761 38.96 µM 0.0422897105200815 0.483131741285227 no 1600 0.483133873882512 2288 2991039 SGTC_1156 4092-0367 4.88 µM 0.0410643952371844 0.483659429576092 no 1601 0.483622279566251 2293 1357585 SGTC_2786 7743617 45.45 µM 0.0408420602458279 0.4837551823718 no 1602 0.483710904044344 2279 583674 SGTC_1438 4092-1045 4 µM 0.0407824353191754 0.483780861140841 no 1603 0.483734671146591 2332 1351342 SGTC_1402 3909-7673 35.9 µM 0.0404602384853783 0.48391962336302 no 1604 0.483863103079607 2329 5328014 SGTC_2719 novobiocin 32.65 µM 0.0397932747815192 0.484206874334371 no 1605 0.484128968966606 2324 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication. SGTC_2407 paclitaxel 400 µM 0.0390713041502578 0.484517825174157 no 1606 0.484416769731888 2236 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_2310 7668677 200 µM 0.0388171790982639 0.484627278411425 no 1607 0.484518074108388 2310 2197143 SGTC_1171 0368-0077 21.4 µM 0.0385633994748829 0.484736584026393 no 1608 0.484619241780553 2314 3239779 SGTC_247 mechlorethamine 29.705 µM 0.037977123686899 0.484989103689501 no 1609 0.484852960760408 2320 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links. SGTC_72 0744-0168 198.391 µM 0.0379759843289878 0.484989594437605 no 1610 0.484853414970797 2224 677577 SGTC_2013 4024628 200 µM 0.0378682234289122 0.485036009680629 no 1611 0.484896374449171 2299 5230760 SGTC_866 0495-0101 262 µM 0.0378277879522723 0.485053426277136 no 1612 0.484912494320666 2306 635694 SGTC_3279 9140807 49.47 µM 0.0377788808549881 0.485074491855955 no 1613 0.484931991492976 2320 45595718 SGTC_1417 3966-0327 90.4 µM 0.0376881475429952 0.485113573200685 no 1614 0.484968163087305 2312 651118 SGTC_2161 5662504 8.5105 µM 0.0375505652063777 0.48517283398759 no 1615 0.485023011673343 2290 2859334 SGTC_984 1492-0255 2.91 µM 0.0371470348491827 0.485346648346986 no 1616 0.485183884750453 2280 1585198 SGTC_2333 9017922 200 µM 0.0368775898466733 0.485462709099345 no 1617 0.485291304151145 2339 3163164 SGTC_2921 7974240 10.71 µM 0.0363598952992936 0.485685704319267 no 1618 0.485497695966998 2310 2979074 YDR527W RBA50 SGTC_313 3474-0040 5.03 µM 0.0359102869780595 0.485879375256144 no 1619 0.485676946668403 2340 1043375 YIL048W NEO1 SGTC_2566 crystal violet carbinol 226 nM 0.0348499622692318 0.486336128308523 no 1620 0.486099690337727 2215 68050 Cationic dye that binds acidic phospholipids including cardiolipin. SGTC_246 cycloheximide 667 µM 0.0341306236812332 0.486646005983713 no 1621 0.486386494269327 2311 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells. SGTC_123 0083-0120 66.675 µM 0.0341291782919483 0.486646628638695 no 1622 0.48638707056048 2330 16001701 SGTC_24 0417-1663 219 µM 0.0336334848144263 0.486860168877765 no 1623 0.486584710172533 2301 4329390 SGTC_3212 9128307 49.47 µM 0.0331248595730229 0.48707928391867 no 1624 0.486787509276298 2244 27243542 SGTC_1219 1469-0211 33.1 µM 0.0320746812749085 0.487531711523938 no 1625 0.487206247217183 2361 6822282 SGTC_1154 4088-0362 150 µM 0.0312680924322607 0.487879209213804 no 1626 0.487527868254952 2339 6618304 SGTC_2301 7769476 200 µM 0.0312541551551361 0.487885213806473 no 1627 0.487533425707875 2310 977820 SGTC_2182 6325192 200 µM 0.030777757364241 0.488090461757314 no 1628 0.487723389533573 2350 736248 SGTC_3226 9131256 49.47 µM 0.0302995564086847 0.488296489743349 no 1629 0.487914075173096 2345 17178073 SGTC_848 0368-0089 85.6 µM 0.0283471970543319 0.489137675603221 no 1630 0.488692618951034 2356 762535 SGTC_2116 5511452 16.8835 µM 0.028076038088123 0.489254509993615 no 1631 0.488800752686901 2329 870744 SGTC_572 0960-0087 17.7 µM 0.0272151272176042 0.489625457125301 no 1632 0.489144075200175 2343 6796365 SGTC_1462 k081-0014 26.5 µM 0.025889892152601 0.490196488535758 no 1633 0.489672581119784 2343 3270634 SGTC_1832 st054113 55 µM 0.0257604545854224 0.490252263070403 no 1634 0.489724202021086 2361 1251267 SGTC_2503 beta-caryophyllene alcohol 24.72 µM 0.0251614738582574 0.490510365807253 no 1635 0.489963083313501 2229 61125 An anti-inflammatory. SGTC_1037 k284-1091 78.7 µM 0.0243174946018979 0.490874045923431 no 1636 0.490299679291444 2347 3334711 SGTC_3228 9131799 49.47 µM 0.024140641799179 0.490950254748854 no 1637 0.490370212645502 2308 17015818 SGTC_57 miconazole 162.5 nM 0.0238248678384251 0.491086327840407 no 1638 0.490496152005335 2368 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_2488 5268135 45.7 µM 0.0231959621521429 0.491357338508204 no 1639 0.490746979739053 2346 1270356 YLR208W SEC13 SGTC_3126 9127922 49.47 µM 0.0230204055676137 0.491432990803281 no 1640 0.490816997986181 2328 45595682 SGTC_2871 9038510 12.99 µM 0.0222335471040809 0.491772074106126 no 1641 0.491130828740055 2376 4945164 SGTC_2804 7954240 19.48 µM 0.0220789120266343 0.491838712175562 no 1642 0.491192504070398 2353 828705 SGTC_3147 9097027 49.47 µM 0.0219769304937714 0.491882659977524 no 1643 0.491233178946141 2338 25236841 SGTC_3333 9141820 12.094 µM 0.0218000129280868 0.491958900858866 no 1644 0.491303741937574 2346 1939433 SGTC_420 mitomycin C 81.9 mM 0.0214838236074594 0.492095160260258 no 1645 0.491429853688554 2370 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_136 0097-0015 404.482 µM 0.0209958634966212 0.492305444791831 no 1646 0.491624477700577 2366 4861337 SGTC_384 k007-0144 5.16 µM 0.0192665423822167 0.493050705889072 no 1647 0.492314237141616 2342 6824886 SGTC_2129 girgensonine 121.053 µM 0.0188934020598912 0.493211516174748 no 1648 0.492463071498159 2351 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_2977 9011197 71.43 µM 0.0186973722407488 0.4932959985394 no 1649 0.492541262268796 2361 2704722 SGTC_871 0574-0004 149 µM 0.0184649234550508 0.493396176662768 no 1650 0.492633979910046 2318 9551173 SGTC_2424 5537928 59.2 µM 0.0184197243353187 0.493415656111833 no 1651 0.492652008683715 2358 5382802 SGTC_2156 5649887 115 µM 0.0178671131096289 0.493653816036857 no 1652 0.492872432380539 2350 54680440 YKL052C | YBR257W ASK1 | POP4 SGTC_876 0720-0963 56.8 µM 0.0177312647197558 0.493712363228934 no 1653 0.492926619462727 2369 765861 SGTC_1205 4161-2785 76 µM 0.0176874773449341 0.493731234499885 no 1654 0.492944085358832 2308 3498106 SGTC_3320 9137005 35.139 µM 0.0169195575493061 0.494062191100726 no 1655 0.493250395165935 2336 4908713 SGTC_1215 3852-0577 11.2 µM 0.0167202303941725 0.494148097413104 no 1656 0.493329903947954 2372 2884876 SGTC_598 3937-0236 20.2 µM 0.0164369493004913 0.494270186784148 no 1657 0.493442901223387 2364 1379313 SGTC_1696 st025591 34.7925 µM 0.0136209604252211 0.495483857802027 no 1658 0.494566191010164 2385 2787147 SGTC_1198 1612-1005 86.7 µM 0.0133664314229899 0.495593560205114 no 1659 0.49466772414648 2363 6998509 SGTC_231 b-estradiol 524 µM 0.0133111289130559 0.495617395718836 no 1660 0.494689784693275 2375 450 A steroid. SGTC_920 mycophenolic acid 780.421 nM 0.0125147604751555 0.495960634108258 no 1661 0.495007463238914 2373 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_2849 9019321 12.99 µM 0.0120046403561849 0.496180499768079 no 1662 0.495210956427135 2365 16489627 SGTC_3178 9107506 49.47 µM 0.011159175448984 0.496544904110589 no 1663 0.495548225493674 2369 8897194 SGTC_1772 st048439 82.2 µM 0.0109678855867818 0.496627352480937 no 1664 0.495624534437087 2370 2927068 YDL195W SEC31 SGTC_1967 st070177 51.4 µM 0.0103458963351682 0.496895438758792 no 1665 0.49587265815349 2385 5729214 SGTC_2381 9035592 200 µM 0.0100664016420578 0.497015905439253 no 1666 0.495984154596166 2357 4749657 SGTC_2272 7805186 180 µM 0.00992405059513629 0.497077261121239 no 1667 0.496040941610683 2383 2956062 YPR165W RHO1 SGTC_1815 st051655 58.2 µM 0.00963448646846253 0.497202068314481 no 1668 0.496156455459634 2389 5984156 SGTC_1977 st070720 65.3 µM 0.00886742043150164 0.497532688457475 no 1669 0.49646245743201 2348 682188 SGTC_3000 9075062 71.4286 µM 0.00778907748104348 0.497997477721541 no 1670 0.496892639087978 2389 17057871 SGTC_2045 5106652 78.05 µM 0.00710078960460081 0.498294146226526 no 1671 0.497167218607889 2390 673349 SGTC_280 3448-3607 3.04 µM 0.00674355103653363 0.498448124959307 no 1672 0.497309732761697 2384 626179 SGTC_1954 st077032 68.9 µM 0.00638214573436348 0.498603899893566 no 1673 0.497453909511359 2358 698907 SGTC_1068 loratadine 26.9 µM 0.00350671832060381 0.499843288318218 no 1674 0.49860102466367 2392 3957 A H1 histamine antagonist. SGTC_490 phenamil 164 µM 0.00350342052477538 0.499844709762219 no 1675 0.498602340285777 2398 4755 Irreversibly blocks amiloride-sensitive Na+ channels. SGTC_1850 st056238 17 µM 0.00323043473507245 0.499962374423796 no 1676 0.498711245241614 2396 5393177 SGTC_2586 curcumin 80 µM 0.00314314219393736 0.5 no 1677 0.498746069750193 2397 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40 SGTC_2572 astragaloside iv 100 µM 0.00280837166897132 0.49985570435368 no 1678 0.498879623274892 2392 45006101 An anti-inflammatory agent. SGTC_3031 9088762 49.47 µM 0.00274186188725582 0.499827036742071 no 1679 0.498906156736703 2401 205253 SGTC_66 0109-0187 42.4 µM 0.00256055198369518 0.499748887010835 no 1680 0.498978488668782 2400 759417 SGTC_1425 4048-4433 7.33 µM 0.00248526526975024 0.499716436295995 no 1681 0.499008523626533 2400 23734946 SGTC_2242 6630449 61.2675 µM 0.00244882430494158 0.499700729204453 no 1682 0.499023061423892 2385 691249 YDR170C SEC7 SGTC_90 0870-0863 4.608 µM 0.000700409046909277 0.49894711352867 no 1683 0.499720577240458 2400 1738164 SGTC_2443 5493264 126.67 µM 0.000589884070367278 0.498899474283308 no 1684 0.499764670317443 2401 5340055 SGTC_1869 3',7'-dimethoxyflavone 40.3 µM -1.02939404038961e-05 0.498640781667465 no 1685 0.499995893311941 2406 688664 SGTC_1837 st055472 66.5 µM -8.13713011968442e-05 0.498610145478511 no 1686 0.499967537547577 2406 676091 SGTC_432 NS 1619 61.3 µM -0.000622977725543505 0.498376699322004 no 1687 0.499751467861608 2415 4552 A K+/calcium channel activator. SGTC_1953 st076800 12.1 µM -0.000801143881622383 0.498299905290771 no 1688 0.499680389867125 2408 297591 SGTC_2650 prasterone 100 µM -0.00113101305510463 0.498157723665699 no 1689 0.49954879116883 2403 16759247 A steroid and weak partial agonist of the androgen receptor. SGTC_1888 azatryptophan 97.5 µM -0.00223651817807519 0.497681225918519 no 1690 0.499107759081713 2430 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides SGTC_2123 5259487 200 µM -0.00244427821280671 0.497591676986599 no 1691 0.499024875046827 2414 2173474 SGTC_2345 9052315 157.45 µM -0.0024618397152105 0.497584107616279 no 1692 0.499017869042091 2413 6469265 SGTC_982 1491-0518 27.5 µM -0.00347914710125106 0.497145628690142 no 1693 0.498612023921693 2419 3091256 SGTC_40 0327-0103 19.753 µM -0.00377503735687071 0.497018094958748 no 1694 0.498493981565272 2417 409036 SGTC_115 0527-0192 112.043 µM -0.00391392955462901 0.496958230164139 no 1695 0.498438572004692 2416 4233931 SGTC_2398 5228213 48.84 µM -0.00459197337916369 0.496665983264148 no 1696 0.498168074106641 2412 80771 YMR134W ERG29 SGTC_2299 7976368 114.88 µM -0.0047848076900308 0.496582869148833 no 1697 0.498091145192536 2414 2979718 SGTC_2405 ticlatone 3.52 µM -0.00529360971379803 0.496363569529558 no 1698 0.497888165132307 2412 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W SGTC_2702 st077768 96.8 µM -0.00551343198561602 0.496268823897113 no 1699 0.497800470014353 2419 6484119 SGTC_2476 5806916 10.51 µM -0.00657091610696766 0.495813040533604 no 1700 0.497378602607959 2421 2870194 SGTC_931 2812-0076 566 µM -0.0071115989672641 0.495580004354332 no 1701 0.497162906404978 2420 3450959 SGTC_752 1896-0090 130 µM -0.00735470435775322 0.495475225578596 no 1702 0.497065923923379 2421 772567 SGTC_2687 chenodiol 100 µM -0.00770917108093142 0.495322450468386 no 1703 0.496924516172342 2421 5702181 A cholesterol synthesis inhibitor. SGTC_322 k048-0136 19.3 µM -0.00812116406286166 0.495144882411946 no 1704 0.496760159902314 2446 6823282 SGTC_2220 6782180 200 µM -0.00861069117784491 0.49493389857046 no 1705 0.496564873674733 2420 833803 SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM -0.00864209407214807 0.49492036412119 no 1706 0.496552346198592 2432 6708739 YPR165W RHO1 SGTC_446 go6976 132 µM -0.00903348630195299 0.494751677035692 no 1707 0.49639620938867 2415 3501 A protein kinase C inhibitor. SGTC_1427 4048-4900 550 nM -0.00924106374774803 0.494662213108276 no 1708 0.496313401426115 2434 24132586 SGTC_719 2810-4230 27.3 µM -0.00961527906885228 0.494500930504682 no 1709 0.496164117748515 2416 721079 SGTC_2040 5100729 123 µM -0.0101232126431852 0.494282018277728 no 1710 0.495961491440602 2430 11840 YJR013W | YDR381W GPI14 | YRA1 SGTC_111 0083-0039 52.457 µM -0.0101926224542841 0.494252103757581 no 1711 0.495933802360848 2425 759313 SGTC_3349 9149703 23.001 µM -0.0107576499305742 0.494008587155919 no 1712 0.495708401380758 2423 4910494 SGTC_1273 0849-0096 14.1 µM -0.0110932115138595 0.493863967246178 no 1713 0.495574539667577 2435 5286025 SGTC_1104 tacrolimus 29.8 µM -0.0120943688122187 0.493432494598179 no 1714 0.495175162550841 2428 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41 SGTC_1852 st056254 31.4 µM -0.0124890017845099 0.493262420177126 no 1715 0.495017738666659 2452 442583 SGTC_1148 3909-7663 27.7 µM -0.0125655037102495 0.49322945038977 no 1716 0.494987221208635 2430 4084526 SGTC_2000 st075254 36.4 µM -0.0133671329621342 0.492883977649639 no 1717 0.494667444297855 2440 17234175 SGTC_1191 1487-1166 10.6 µM -0.0140867985512917 0.492573832774394 no 1718 0.494380366321052 2469 3955771 SGTC_2287 7945887 168.79 µM -0.0156853549819767 0.491884940130944 no 1719 0.493742705296382 2437 1245853 SGTC_1543 azetidyl-2-carboxylic acid 198 µM -0.0162318359896487 0.491649441383625 no 1720 0.493524718679529 2440 16486 A toxic proline analog. SGTC_1444 4112-3581 28 µM -0.0163374498552178 0.491603928821114 no 1721 0.493482590429533 2435 2877249 SGTC_2259 7964009 200 µM -0.0167424711193929 0.491429392571239 no 1722 0.493321032424143 2512 313134 SGTC_1249 0481-0015 10.2 µM -0.0173514392756059 0.491166972366338 no 1723 0.493078124579878 2446 4227577 SGTC_1146 3579-1023 7 µM -0.0202189636537322 0.489931334861215 no 1724 0.491934350084711 2485 X1146 SGTC_2495 cafestol 54.53 µM -0.0202243994476359 0.489928992625349 no 1725 0.491932181960031 2554 16667697 An anti-infammatory. SGTC_3306 9127676 59.7925 µM -0.0205815628802233 0.489775094803139 no 1726 0.491789724020914 2461 41905287 SGTC_2465 5809242 33.21 µM -0.0214462883483137 0.489402500392572 no 1727 0.491444824641112 2449 2731748 SGTC_1003 4049-0218 100 µM -0.0215063224856832 0.489376633118833 no 1728 0.4914208800081 2467 295161 SGTC_2591 skatole 100 µM -0.0215801585820838 0.489344818972385 no 1729 0.491391430502149 2464 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite. SGTC_1684 st024538 14.6195 µM -0.022702217598562 0.488861359974802 no 1730 0.490943903452373 2453 6732859 SGTC_2671 danthron 100 µM -0.0239072925297206 0.488342150346819 no 1731 0.490463278674527 2458 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin. SGTC_2882 9058044 58.44 µM -0.0240310412764383 0.488288833985266 no 1732 0.49041392424696 2471 18076804 SGTC_2067 5224629 34.075 µM -0.0242290109122094 0.488203540460687 no 1733 0.490334968778723 2476 2835000 SGTC_898 1000-0849 28.3 µM -0.0246877531135693 0.488005897386498 no 1734 0.49015201185214 2439 6751807 SGTC_2325 6158266 200 µM -0.0247140156229584 0.487994582616689 no 1735 0.490141537822523 2481 3623240 SGTC_2683 piperine 63.03 µM -0.0247637581481459 0.487973151895117 no 1736 0.490121699497674 2452 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_1785 bathophenanthroline 24 µM -0.0249699168474304 0.487884332294233 no 1737 0.490039479500895 2457 72812 An iron chelator. SGTC_1102 cgs 12066b 26.1 µM -0.0250435172524008 0.487852623088384 no 1738 0.490010126366723 2482 6438352 A 5-HT1B full agonist. SGTC_315 k915-0449 187 µM -0.0262491326148826 0.487333219826572 no 1739 0.489529313603288 2471 20970215 YNL149C PGA2 SGTC_1014 4130-3005 69.3 µM -0.0263518683252924 0.487288960204433 no 1740 0.489488342157476 2467 743608 SGTC_3189 9110682 49.47 µM -0.0265195363595023 0.487216727392304 no 1741 0.489421475658424 2476 17122418 SGTC_248 streptozotocin 5.23457 mM -0.0289833188145472 0.486155358603285 no 1742 0.488438947331694 2506 5300 DNA alkylating agent. SGTC_411 enrofloxacin 100 µM -0.0295713103629936 0.485902072904194 no 1743 0.48820447315849 2466 71188 A bacterial gyrase inhibitor. SGTC_1715 st032160 10.2275 µM -0.0298030233056827 0.485802260824264 no 1744 0.488112073794982 2473 5289825 SGTC_658 3253-0951 102 µM -0.0300465679067754 0.48569735312801 no 1745 0.48801495705012 2483 1184878 SGTC_368 fentichlor 4.58 µM -0.030399725924739 0.485545230826014 no 1746 0.487874131718161 2480 7329 A pesticide. SGTC_378 3970-0959 8.33 µM -0.0308317073479926 0.485359158319393 no 1747 0.487701876813501 2499 6615653 SGTC_1644 st010134 20.9 µM -0.0317162685806454 0.484978150708993 no 1748 0.487349160481146 2475 3818134 SGTC_2189 6047310 154.431 µM -0.0317589253940427 0.484959777457034 no 1749 0.487332151443283 2447 711535 SGTC_3071 9117417 49.47 µM -0.0327422003078924 0.484536267697495 no 1750 0.486940085469379 2482 45595590 YGL055W OLE1 SGTC_1276 0871-0068 94.2 µM -0.0334057458702251 0.484250479507942 no 1751 0.486675513839848 2495 3414906 SGTC_1265 0819-1001 68.8 µM -0.0335407125823688 0.484192350510267 no 1752 0.486621700068424 2465 3106768 SGTC_1702 st027038 51 µM -0.0335591970572546 0.484184389432649 no 1753 0.486614329978913 2500 5521182 SGTC_440 fluspirilene 35.1 µM -0.0343831652950837 0.483829521042277 no 1754 0.486285803841467 2675 3396 An atypical antipsychotic. SGTC_2607 solasodine 47.35 µM -0.034629446159258 0.483723454750327 no 1755 0.486187610468242 2485 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity. SGTC_1737 st035557 69.7 µM -0.0347848704059978 0.483656518459084 no 1756 0.486125642499022 2456 5716916 SGTC_1442 4112-3290 3 µM -0.0350624328827007 0.483536982254812 no 1757 0.486014978598795 2453 704353 SGTC_3068 9116768 49.47 µM -0.0355926872554983 0.483308624836036 no 1758 0.485803569676789 2506 41904888 SGTC_595 3909-8003 73.7 µM -0.0364268396251973 0.482949402921895 no 1759 0.485471006725467 2497 699517 SGTC_3297 9117502 71.43 µM -0.0371270616486918 0.482647867853175 no 1760 0.485191847411817 2463 7453720 SGTC_617 3770-0098 35 µM -0.0378922202438902 0.482318380646209 no 1761 0.484886807971068 2477 5962639 SGTC_1350 1495-0454 146 µM -0.0380139935040777 0.482265944610361 no 1762 0.484838262444999 2492 1069057 SGTC_1720 st037298 9.481 µM -0.0391243697073274 0.481787826596562 no 1763 0.484395615812096 2509 597396 SGTC_1119 parthenolide 318.541 nM -0.0412140884161086 0.480888084083988 no 1764 0.483562611142047 2604 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs. SGTC_31 0508-1974 57.237 µM -0.0420611653929506 0.480523396837365 no 1765 0.483224969141821 2477 6810525 SGTC_2766 oltipraz 83.91 µM -0.0420797383524697 0.48051540090795 no 1766 0.483217566157253 2501 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40 SGTC_1256 0570-0116 285 µM -0.0424144304160519 0.480371312449566 no 1767 0.483084162446482 2494 410638 SGTC_3096 9117468 49.47 µM -0.0427182956672133 0.480240497479279 no 1768 0.482963047524208 2471 41316311 SGTC_3302 9125395 16.351 µM -0.0439611152807034 0.479705481930562 no 1769 0.482467699697208 2512 17599668 SGTC_310 1273-0058 1.06 µM -0.0454902099932845 0.4790472794297 no 1770 0.481858289057776 2487 2734232 SGTC_1116 jasmonic acid  1.58368 µM -0.0466105896935718 0.478565045456997 no 1771 0.481411795925084 2551 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid. SGTC_2447 5741742 33.78 µM -0.0479020063586191 0.478009232705682 no 1772 0.480897170192636 2545 1776504 SGTC_387 norethindrone acetate 66.7 µM -0.0508690273808875 0.476732420455818 no 1773 0.47971494305671 2529 541197 SGTC_1126 isoteolin 1.0172 µM -0.0512510585574713 0.476568036244624 no 1774 0.479562733213515 2501 133323 SGTC_2459 5811157 9.22 µM -0.0517795416567066 0.476340641808668 no 1775 0.479352178536397 2490 2870684 YBR192W RIM2 SGTC_2030 5175110 200 µM -0.0523535049317934 0.476093687002147 no 1776 0.479123510482585 2560 2831986 SGTC_312 4092-0653 6.84 µM -0.0524812826918049 0.47603871028493 no 1777 0.479072604513907 2588 1148278 SGTC_2740 felodipine 17.08 µM -0.0542688251776001 0.47526966372838 no 1778 0.47836049342114 2528 3333 L-type calcium channel blocker SGTC_1070 indatraline 8.81 µM -0.0544432348686565 0.475194633099414 no 1779 0.478291016734348 2520 10314472 A monamine transport inhibitor. YGL099W LSG1 SGTC_2576 guaiol 23.12 µM -0.0546618639079253 0.475100580656165 no 1780 0.478203926053586 2583 227829 SGTC_2635 hydroquinidine 100 µM -0.0554628972850384 0.474755994474818 no 1781 0.477884844053674 2517 442912 An experimental heart treatment. SGTC_1456 k015-0012 13 µM -0.0577671302861695 0.473764872483004 no 1782 0.476967060335222 2503 2989616 SGTC_2729 fluphenazine 10.66 µM -0.0582291523886064 0.473566161810721 no 1783 0.476783049931782 2517 3372 An atypical antipsychotic. SGTC_1134 3477-0009 42.5 µM -0.059934264309212 0.472832869062165 no 1784 0.4761039949818 2566 3973534 SGTC_3095 9117207 49.47 µM -0.0601510348947086 0.472739652225087 no 1785 0.476017671773346 2497 17015229 SGTC_3173 9105693 49.47 µM -0.0608108594565709 0.472455920176644 no 1786 0.475754920866645 2581 17096658 SGTC_367 0335-0881 7.1 µM -0.0608133788873607 0.472454836819511 no 1787 0.475753917615965 2554 23828853 SGTC_2489 cantharidin 73.42 µM -0.0608414395528138 0.472442770726047 no 1788 0.475742743720792 2529 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_61 0978-8327 98.565 µM -0.0616318057328399 0.472102923491095 no 1789 0.475428023884025 2522 6150059 YHR072W ERG7 SGTC_429 1112-0049 25.5 µM -0.0620760594180809 0.471911909052656 no 1790 0.475251131019077 2536 2836170 SGTC_3232 9132874 49.47 µM -0.062278313680503 0.471824948525238 no 1791 0.475170599061469 2525 3784940 SGTC_3132 9126706 49.47 µM -0.0625444529825425 0.471710522259328 no 1792 0.475064631424376 2673 850858 SGTC_1861 st057647 17.4 µM -0.0630473234338552 0.471494320108765 no 1793 0.474864410299659 2600 688668 SGTC_259 usnic acid 108.925 µM -0.0638048298598575 0.471168656643336 no 1794 0.474562816212841 2652 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_850 0388-0143 75.9 µM -0.0658187289559417 0.470302945314461 no 1795 0.473761072508686 2538 67273 SGTC_512 prima-1 270 µM -0.0659516009937606 0.470245832731288 no 1796 0.473708179160806 2647 322968 A re-activator of the apoptotic function of mutant p53. SGTC_1382 3002-2117 298 µM -0.0659669109705318 0.470239252060789 no 1797 0.473702084635682 2521 1497314 SGTC_1645 Cervolide 78 µM -0.0664175669292935 0.470045550753445 no 1798 0.473522692347921 2583 23173 A fragrance. SGTC_1212 0520-0165 585 µM -0.0675233038868614 0.469570312128511 no 1799 0.473082555270473 2681 5403258 SGTC_1948 st076329 66.6 µM -0.0676476609854798 0.469516866947325 no 1800 0.4730330571439 2515 24208413 SGTC_3172 9105863 49.47 µM -0.068997450522681 0.468936800927295 no 1801 0.472495824426519 2520 2348785 SGTC_479 n-linoleoylglycine 10 µM -0.0699699984576765 0.46851889359497 no 1802 0.472108769427852 2538 6433346 An anti-infammatory. SGTC_3149 9097855 49.47 µM -0.0710231315011596 0.468066397683803 no 1803 0.471689672850089 2604 25236625 YMR079W SEC14 SGTC_2253 7938677 135.83 µM -0.0719768070468476 0.46765667089927 no 1804 0.47131018263188 2670 2301972 SGTC_1248 0469-0687 58.6 µM -0.0724548587790928 0.467451298819893 no 1805 0.471119964239214 2590 4017482 SGTC_2436 5633522 8.09 µM -0.0727697389047805 0.467316030352198 no 1806 0.470994675974157 2561 5724242 SGTC_645 0845-0943 5.41 µM -0.0730674922012928 0.467188122822627 no 1807 0.470876204977052 2572 1885106 SGTC_961 1252-1571 372 µM -0.0748845208683528 0.466407645682179 no 1808 0.47015329626561 2578 6813498 SGTC_2291 7917025 104.35 µM -0.0749764961268211 0.466368142512371 no 1809 0.470116706309224 2549 2964612 SGTC_2320 7373003 200 µM -0.0750584722294928 0.466332934237072 no 1810 0.470084094468689 2573 5415828 SGTC_2778 tioconazole 65.09 nM -0.0756152896237686 0.466093791282976 no 1811 0.469862585965163 2527 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_1607 st000305 50.6 µM -0.0758679303964976 0.465985290693424 no 1812 0.469762085568184 2551 5457690 SGTC_2198 6589944 200 µM -0.0759178974238982 0.465963831859676 no 1813 0.469742208932904 2560 5290268 SGTC_1498 4478-3555 97.6 µM -0.0760388581296798 0.465911884498965 no 1814 0.469694091677331 2525 3437919 SGTC_1625 st003711 30.1 µM -0.0761322660203269 0.465871770271037 no 1815 0.469656935026408 2604 24207034 YER133W GLC7 SGTC_3287 9117173 37.0625 µM -0.0763966292576296 0.465758240767188 no 1816 0.469551775616628 2538 2789709 SGTC_2349 9023730 187.07 µM -0.0766012454141655 0.465670371268635 no 1817 0.469470384084621 2591 4126287 SGTC_3059 1327-0034 3 µM -0.076625467949276 0.465659969356111 no 1818 0.46946074900981 2563 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_1283 0922-0125 16.4 µM -0.0767479342891151 0.465607378847121 no 1819 0.469412035458298 2601 3360884 SGTC_2533 agelasine 13.65 µM -0.0772061604505828 0.465410608912846 no 1820 0.469229770473294 2587 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase. SGTC_355 1311-2252 105 µM -0.0793909864245946 0.464472525419694 no 1821 0.468360818902053 2577 5338538 SGTC_2582 agaric acid 100 µM -0.0795153959691626 0.464419114453532 no 1822 0.468311343087091 2540 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase. SGTC_3153 9100258 49.47 µM -0.0802882684924289 0.46408732257424 no 1823 0.468003994239462 2589 25236848 SGTC_1587 estradiol valerate 56.1 µM -0.0806542494722241 0.463930216725132 no 1824 0.467858460926748 2556 13791 A steroid. SGTC_2670 beta-carotene 100 µM -0.0808829934292045 0.46383202591513 no 1825 0.467767502462475 2549 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.) SGTC_2119 5528445 120.635 µM -0.0848939861832878 0.462110627352259 no 1826 0.466172836429706 2648 791935 SGTC_780 0109-0199 192 µM -0.0853792627079717 0.461902408599745 no 1827 0.465979939458756 2612 610414 SGTC_2693 st077581 40.7 µM -0.0855831926739837 0.461814910996747 no 1828 0.465898879867721 2558 25238761 SGTC_958 1222-0007 33 µM -0.0864662584868141 0.461436046707929 no 1829 0.465547888707399 2662 7312461 SGTC_278 4092-0821 23.9 µM -0.0867828285032258 0.461300236258428 no 1830 0.465422068495927 2640 877900 SGTC_1725 st036284 20.55 µM -0.0877802683333979 0.460872358130646 no 1831 0.465025660403271 2692 707914 SGTC_3337 9144342 33.5465 µM -0.0881782208390497 0.46070165851861 no 1832 0.464867513565862 2654 17682949 SGTC_1601 4'-hydroxyflavanone 55.5 µM -0.088384481926406 0.460613186768841 no 1833 0.464785547326516 2712 165506 SGTC_2922 7999257 32.47 µM -0.0914935119737783 0.45927986642559 no 1834 0.46355023065501 2563 2988377 SGTC_1230 0170-0365 3.77 µM -0.0925385045432083 0.45883181912847 no 1835 0.463135100124315 2650 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1 SGTC_825 1988-2224 89.6 µM -0.0933792219265386 0.458471394064607 no 1836 0.462801148442392 2578 1180859 SGTC_3273 9137859 49.47 µM -0.0964921829472418 0.457137131966726 no 1837 0.461564841031052 2563 2377234 SGTC_573 3702-0553 84.7 µM -0.0965263838786685 0.457122475586171 no 1838 0.461551260227063 2586 1222756 SGTC_324 1315-0088 19.6 µM -0.0966751193715695 0.457058737533213 no 1839 0.46149219956264 2560 6787421 SGTC_1665 st014639 11.4 µM -0.0976151503799376 0.456655928932713 no 1840 0.461118946849985 2607 981133 YIL048W NEO1 SGTC_395 anisomycin 6.25 µM -0.0981927218071038 0.45640845837246 no 1841 0.460889630846358 2615 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_568 1193-0097 7.48 µM -0.0987482323138223 0.456170456148304 no 1842 0.46066908606606 2591 3646150 SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM -0.0990069111878396 0.456059633457213 no 1843 0.46056639136691 2761 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W SGTC_2799 7812892 81.82 µM -0.100735700565489 0.455319077111864 no 1844 0.459880135278034 2654 20205235 SGTC_1768 st044301 37.178 µM -0.102186528758091 0.454697709862353 no 1845 0.459304310136563 2622 3931349 SGTC_1614 st002383 48.6 µM -0.104633443715706 0.453649985951539 no 1846 0.458333338054183 2593 1947235 SGTC_1716 st033144 30.6155 µM -0.105616289971202 0.453229239665619 no 1847 0.457943399757595 2639 674617 SGTC_1734 st037168 69.4 µM -0.107541430441135 0.452405259556783 no 1848 0.457179729571125 2703 708907 SGTC_2217 6934799 96.0675 µM -0.109338123804782 0.451636440948367 no 1849 0.456467154709523 2613 675606 SGTC_29 0299-0004 12.984 µM -0.109383452940828 0.451617046603388 no 1850 0.456449178816545 2593 16871 A napthoquinone isolated from Swertia calycina. SGTC_3237 9133362 49.47 µM -0.109407680534991 0.451606680728064 no 1851 0.456439571067068 2601 43845137 SGTC_1392 3455-1037 33.9 µM -0.109999548643281 0.45135345780138 no 1852 0.45620486643686 2722 981132 SGTC_1695 st026914 34.495 µM -0.110016201750858 0.451346333275811 no 1853 0.45619826288648 2594 3289191 SGTC_1780 st038448 24.544 µM -0.110450436917215 0.451160564506279 no 1854 0.456026077450539 2807 728868 YDL195W SEC31 SGTC_1263 0774-1208 64.8 µM -0.111581376195694 0.450676791266608 no 1855 0.455577669718471 2633 906585 SGTC_2329 6138490 200 µM -0.111776415274652 0.450593368279734 no 1856 0.4555003440997 2876 720019 SGTC_1611 st001856 99.4 µM -0.113371311496154 0.449911274364466 no 1857 0.454868091578626 2617 647478 SGTC_2096 5468907 200 µM -0.11377838129827 0.449737205255662 no 1858 0.45470673825586 2724 759785 SGTC_146 3448-8650 53.125 µM -0.113785743727581 0.449734057060197 no 1859 0.454703820023036 2643 2891488 YIL048W NEO1 SGTC_2654 protoveratrine a 100 µM -0.114003152465829 0.449641093899615 no 1860 0.454617647216334 2609 5702278 A heart drug and vasodilator. SGTC_1912 st060209 90.8 µM -0.114396764509159 0.449472793901912 no 1861 0.454461639353655 2673 688787 SGTC_3138 9097216 49.47 µM -0.11552414968835 0.448990798780584 no 1862 0.454014839968654 2575 25237486 SGTC_527 4476-4215 268 µM -0.115831351172914 0.448859472822456 no 1863 0.453893101550934 2621 4418754 SGTC_2854 9024559 71.43 µM -0.115845902455016 0.448853252415006 no 1864 0.45388733524717 2685 3163529 SGTC_391 gliotoxin 8.33 µM -0.116676999279463 0.44849799460747 no 1865 0.453558008839481 2734 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion SGTC_933 2914-0560 114 µM -0.116692042543944 0.448491564644699 no 1866 0.453552048161819 2726 463887 SGTC_1406 3909-7906 11.9 µM -0.119748980539393 0.44718521660907 no 1867 0.452340999316948 2655 X1406 SGTC_2850 9015429 58.44 µM -0.119868685809248 0.447134073471681 no 1868 0.45229358534154 2663 6457570 SGTC_1643 st009866 20.2 µM -0.120046464184934 0.447058120677955 no 1869 0.452223170486519 2635 3156273 YOR207C RET1 SGTC_2219 9098279 200 µM -0.120771691081696 0.446748299941089 no 1870 0.451935936594351 2630 902349 SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM -0.120783224163505 0.446743373210035 no 1871 0.4519313689964 2658 2374 Ca(2+)-ATPase inhibitor. SGTC_3077 9117319 49.47 µM -0.121348796413948 0.446501780725685 no 1872 0.451707385803922 2607 17154678 SGTC_2877 9040724 71.43 µM -0.123329201216687 0.445655978832332 no 1873 0.450923209055679 2720 6463895 SGTC_2118 5526350 200 µM -0.12336471337896 0.445640814353077 no 1874 0.450909149117804 2761 743594 SGTC_2546 rhodinyl acetate 100 µM -0.123693159408203 0.445500564401344 no 1875 0.450779114033515 2632 6708682 SGTC_2060 5238662 140 µM -0.125825977605306 0.4445899950311 no 1876 0.449934839020222 2719 790130 SGTC_3206 9114350 49.47 µM -0.127558274029689 0.44385063633791 no 1877 0.44924927689905 2694 17087243 SGTC_626 0214-0009 33 µM -0.127931964725308 0.443691167537371 no 1878 0.449101407345305 2727 3437874 SGTC_3012 9080433 71.4286 µM -0.128238310107468 0.443560444481778 no 1879 0.448980191630292 2629 17688859 SGTC_1941 st076221 61.8 µM -0.129453377184942 0.443042014245532 no 1880 0.448499457034156 2801 2828568 SGTC_1800 st050079 29.0735 µM -0.131684153784013 0.442090467698591 no 1881 0.447617059903438 2704 3645560 SGTC_1464 k208-0027 110 µM -0.131735022648523 0.442068773258747 no 1882 0.447596941423429 2735 X1464 SGTC_1234 0326-0494 15.5 µM -0.131946217094395 0.441978705381561 no 1883 0.447513416109731 2752 1547813 SGTC_1550 gossypolone 36.6 µM -0.132553120982748 0.441719896418211 no 1884 0.447273404594105 2658 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_1510 1123-0200 71.5 µM -0.133419737353922 0.441350378445855 no 1885 0.446930718400387 2846 5378812 YNL149C | YNL150W PGA2 | YNL150W SGTC_453 enantio-paf c16 10 µM -0.133890905807129 0.4411494975588 no 1886 0.446744420824544 2683 13871343 A lipid and platelet activating factor SGTC_565 1418-0001 44.5 µM -0.133969232220643 0.441116104855028 no 1887 0.446713452102825 2764 2862145 SGTC_2255 7941087 197.44 µM -0.134886836676478 0.440724936086054 no 1888 0.446350673620706 2750 935561 SGTC_2493 resveratrol 26.09 µM -0.13539787472366 0.440507108961888 no 1889 0.446148652192558 2615 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase. SGTC_276 colchicine 750 µM -0.135550198949822 0.440442185087666 no 1890 0.446088438716957 2759 2833 A microtubule depolymerizer. SGTC_3121 9125696 49.47 µM -0.135957778629539 0.440268473705912 no 1891 0.445927329365846 2602 1235365 SGTC_3017 9080681 49.47 µM -0.136794244200272 0.439912006229326 no 1892 0.445596716668772 2722 16451914 SGTC_1833 st055984 71 µM -0.137060532976819 0.439798535031178 no 1893 0.445491474058905 2688 676288 SGTC_406 estrone 100 µM -0.137487583006825 0.439616570440413 no 1894 0.445322703433231 2754 5870 A steroid. SGTC_2470 5664817 21.68 µM -0.138579575173527 0.439151334329344 no 1895 0.444891192103626 2652 2859561 SGTC_2359 9039622 200 µM -0.138901684187639 0.439014117915919 no 1896 0.444763920040717 2664 6463596 SGTC_548 1436-0017 110 µM -0.1392496407806 0.438865898831214 no 1897 0.444626441452761 2724 9677137 SGTC_2713 st079149 53.4 µM -0.139664422065946 0.438689225630977 no 1898 0.444462568952833 2724 3103253 SGTC_2955 9076254 12.21 µM -0.139912097371294 0.438583735882007 no 1899 0.44436472149422 2684 16459619 SGTC_1140 3229-1848 2.98 µM -0.140175832087906 0.438471410912817 no 1900 0.444260533276987 2751 2849525 SGTC_937 3122-0005 46.7 µM -0.140351317640023 0.438396674126409 no 1901 0.444191209964739 2784 759535 SGTC_17 0960-0276 49.807 µM -0.140351516758771 0.43839658932583 no 1902 0.444191131306405 2651 6821114 SGTC_1002 4049-0206 172 µM -0.140382984491565 0.438383187901221 no 1903 0.444178700563768 2663 4662749 SGTC_1239 0337-0584 35.4 µM -0.140788400503804 0.438210536342625 no 1904 0.444018553423031 2791 914301 YML130C ERO1 SGTC_576 1073-0113 22.7 µM -0.140828507771005 0.438193456792142 no 1905 0.444002710775711 2680 5439563 SGTC_607 4491-0986 66.8 µM -0.140836370298113 0.438190108573808 no 1906 0.443999605033735 2758 698981 YDR232W HEM1 SGTC_1969 st069479 40.1 µM -0.141305887779237 0.43799017490288 no 1907 0.443814149256214 2789 3895485 SGTC_79 0052-0007 94.094 µM -0.141933357253036 0.437723005576847 no 1908 0.443566322877671 2788 2801472 SGTC_2678 equilin 100 µM -0.142420481679503 0.437515613135097 no 1909 0.443373942623259 2731 3247 Equilin is an estrone commonly used hormone replacement therapy SGTC_3222 9128301 49.47 µM -0.144926936006172 0.436448766851004 no 1910 0.442384279547477 2697 4911358 SGTC_1260 0700-1617 7.75 µM -0.145660971797312 0.436136419269971 no 1911 0.442094516338842 2743 2853078 SGTC_1155 4088-0394 48.2 µM -0.145888254668669 0.436039713720086 no 1912 0.44200480190067 2651 2326248 SGTC_1349 flufenamic acid 69 µM -0.146024387186515 0.435981793148018 no 1913 0.441951068292862 2654 3371 A non-steroidal anti-inflammatory. SGTC_1541 2',3',6-trimethoxyflavone 64 µM -0.146981198143753 0.435574735700624 no 1914 0.441573430419132 2686 688801 SGTC_757 1066-0008 322 µM -0.146981814659275 0.435574473437504 no 1915 0.441573187107469 2825 6842497 SGTC_1001 4048-4355 44.4 µM -0.147233675289632 0.435467335352178 no 1916 0.441473790597678 2681 21824233 SGTC_309 k408-0051 1.48 µM -0.147329896759406 0.435426405298172 no 1917 0.441435817877364 2684 3640463 SGTC_2196 6573537 42.6665 µM -0.147461062045848 0.435370612188274 no 1918 0.441384055840118 2746 2903087 SGTC_2917 7979103 53.79 µM -0.148433877051964 0.434956851051967 no 1919 0.441000183082179 2805 2980565 SGTC_2385 9074692 200 µM -0.150429523496877 0.434108278991083 no 1920 0.440212874951517 2707 17046906 SGTC_2084 5306078 60.6385 µM -0.151678015249046 0.433577559888709 no 1921 0.439720448906855 2751 679340 SGTC_3307 9126885 69.2785 µM -0.151964548774297 0.43345577472959 no 1922 0.439607448416457 2679 24824909 SGTC_3298 9116858 71.43 µM -0.153101343696863 0.43297266588592 no 1923 0.439159178127208 2792 2506942 SGTC_3300 9124615 50.48 µM -0.154477529128045 0.432387956263251 no 1924 0.438616613848322 2852 24824903 SGTC_2757 clomiphene 4.22 µM -0.154578564792608 0.432345034344823 no 1925 0.438576784836909 2825 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined. SGTC_351 caspofungin 25 nM -0.155572129357097 0.431922991372579 no 1926 0.438185147483871 2715 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1 SGTC_2752 diclazuril 33.15 µM -0.155918063113078 0.431776065017763 no 1927 0.438048803566968 2809 456389 An antifungal agent for coccidioides. YHR062C RPP1 SGTC_633 0437-0093 97.7 µM -0.15663543990598 0.431471408004468 no 1928 0.437766085138477 2656 2831118 SGTC_1767 st044992 70.3 µM -0.157616232956489 0.431054948841394 no 1929 0.437379605709368 2727 9600693 SGTC_2127 5253358 187.912 µM -0.158224061679542 0.430796894259226 no 1930 0.437140122046244 2667 20612 SGTC_1475 4092-1048 11.7 µM -0.159629975097356 0.430200125021648 no 1931 0.436586282521697 2742 2881759 SGTC_1193 1488-0126 41.5 µM -0.160381324271813 0.429881264482935 no 1932 0.436290350127683 2710 1384710 SGTC_2404 5161160 200 µM -0.160464819686246 0.429845833187707 no 1933 0.436257466154596 2665 2831543 SGTC_2811 7967822 32.47 µM -0.160860530190429 0.429677921047622 no 1934 0.436101624866285 2809 2232244 SGTC_2437 5741531 144.16 µM -0.161025034389431 0.429608120596804 no 1935 0.436036841668789 2846 2262990 SGTC_124 0136-0217 7.121 µM -0.161172035319441 0.42954574878502 no 1936 0.435978952864076 2742 3976905 SGTC_2827 7993847 71.43 µM -0.161796151058023 0.429280958977863 no 1937 0.435733192059329 2794 2985692 SGTC_703 3875-0075 71.8 µM -0.161859406822931 0.429254123611145 no 1938 0.435708284941484 2712 2850814 SGTC_707 0865-0008 204 µM -0.161937333772138 0.429221064650777 no 1939 0.435677601358215 2712 723043 SGTC_80 0159-0065 512.242 µM -0.163472968068379 0.428569703872158 no 1940 0.435073027595652 2649 1548079 SGTC_972 1319-0219 195 µM -0.165126921651224 0.427868373935341 no 1941 0.434422041729129 2766 23903702 SGTC_2581 avocatin a 64 µM -0.165471396367485 0.427722334081024 no 1942 0.434286480928718 2766 6710728 A skin care supplement. SGTC_1023 4482-3888 16 µM -0.165738776337946 0.427608985323538 no 1943 0.434181264474324 2907 3303168 SGTC_1773 st048542 73.5835 µM -0.165752127765056 0.427603325491147 no 1944 0.434176010688279 2677 3237138 SGTC_1118 chelidonine 707.474 nM -0.166379276523781 0.427337486307723 no 1945 0.433929240791761 2709 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor. SGTC_2619 obliquin 87.91 µM -0.166904999995138 0.42711466523328 no 1946 0.43372239945524 2716 6708593 A bioactive alkalod. YER133W GLC7 SGTC_2363 9053361 176 µM -0.167125616571217 0.42702116668105 no 1947 0.433635605181123 2839 6469797 YMR079W SEC14 SGTC_2689 tacrolimus 100 µM -0.167455065683844 0.42688155191843 no 1948 0.433506000314134 2793 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). SGTC_2012 4023501 200 µM -0.168153631933478 0.426585542102547 no 1949 0.433231208899653 2768 3477460 SGTC_1586 deoxycorticosterone acetate 53.7 µM -0.168224316034197 0.426555592787827 no 1950 0.433203406054336 2702 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE. SGTC_1063 disulfiram 1.84 µM -0.169724755960671 0.425919946771855 no 1951 0.432613302045711 2685 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_51 1013-0126 23.419 µM -0.170367775377469 0.425647596988286 no 1952 0.432360456577429 2820 1627850 SGTC_656 4090-1979 187 µM -0.170391993141594 0.425637340287634 no 1953 0.432350934307742 2784 22330961 SGTC_562 3772-2733 112 µM -0.172684770148891 0.424666532853412 no 1954 0.431449607800788 2808 2876874 YIL048W NEO1 SGTC_361 000s-0510 1.45 µM -0.172752844789617 0.424637715648659 no 1955 0.431422852025883 2799 660 SGTC_2592 piperlongumine 83.33 µM -0.173754460686116 0.424213760488506 no 1956 0.431029217498445 2781 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM -0.175379527869088 0.423526103091504 no 1957 0.430390712834715 2659 5711223 A potent inhibitor of glutathione S-transferases. SGTC_1787 fluconazole 80 µM -0.175970752628604 0.423275980274141 no 1958 0.430158459944022 2753 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C SGTC_1807 st050092 58.9 µM -0.17631763038278 0.423129244984133 no 1959 0.430022205983895 2737 5008496 SGTC_149 3970-0822 46.1 µM -0.176499419789978 0.423052349177382 no 1960 0.429950802233436 2714 3114250 YBL034C STU1 SGTC_2139 5578692 56.4705 µM -0.177383382919408 0.422678480017423 no 1961 0.42960362942657 2758 650991 YMR113W FOL3 SGTC_2732 terfenadine 20 µM -0.178135967799859 0.422360231704695 no 1962 0.429308097763761 2710 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.  SGTC_118 0083-0097 135.343 µM -0.178401764836675 0.42224784524214 no 1963 0.429203731699499 2755 5207356 SGTC_81 0411-0046 9.971 µM -0.178812838452192 0.422074044225365 no 1964 0.429042332065606 2704 12925265 SGTC_122 0236-0016 402.397 µM -0.178985349936733 0.422001111269066 no 1965 0.428974602497673 2749 6808838 SGTC_587 k089-0003 57 µM -0.179404098737155 0.421824087300418 no 1966 0.428810206637055 2696 9659696 SGTC_1509 1326-1131 80 µM -0.179559202976923 0.421758521762983 no 1967 0.42874931766717 2720 768313 SGTC_745 0469-0705 296 µM -0.18013174628646 0.421516515516316 no 1968 0.428524570147212 2873 3486736 SGTC_845 0330-0138 4.51 µM -0.180556403229307 0.421337037960487 no 1969 0.428357889262141 2810 9039800 SGTC_1862 st057513 3.81 µM -0.180571334200635 0.421330727812783 no 1970 0.428352028981581 2750 5393163 SGTC_1985 st071382 65.5 µM -0.181541207606358 0.42092088193124 no 1971 0.427971395738211 2730 6123237 SGTC_1320 1313-0481 95.3 µM -0.182462944340173 0.420531456890783 no 1972 0.427609716151838 2831 6813365 YLR208W SEC13 SGTC_2737 bleomycin 30.5 nM -0.182938462215214 0.420330585475484 no 1973 0.427423151813445 2741 16211318 Bleomycin acts by induction of DNA strand breaks. SGTC_1904 st060225 78 µM -0.183020314467015 0.420296010995861 no 1974 0.427391039596336 2726 66595 SGTC_900 1112-0045 141 µM -0.183394752707146 0.420137855723995 no 1975 0.427244146389676 2759 56211 YIL048W NEO1 SGTC_2776 terbinafine 19.92 µM -0.183465406675635 0.420108014337085 no 1976 0.427216429763719 2700 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_1739 st037196 92.5 µM -0.183803960586139 0.419965029194642 no 1977 0.4270836244889 2855 612214 SGTC_184 1494-0393 24.714 µM -0.184377100484776 0.419722992897867 no 1978 0.426858816505672 2714 3090647 SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM -0.184703159481649 0.419585312116487 no 1979 0.426730933955012 2866 5024745 SGTC_1495 4469-0029 237 µM -0.185371232004838 0.419303244401949 no 1980 0.426468935448811 2723 793680 SGTC_1854 st056233 32.9 µM -0.185847418994062 0.419102218215249 no 1981 0.426282208635297 2713 5393174 SGTC_700 3453-2283 142 µM -0.186001420979861 0.419037209548721 no 1982 0.42622182349712 2913 565664 SGTC_2016 5121758 140 µM -0.186629227826125 0.418772217117481 no 1983 0.425975674433915 2691 2795203 SGTC_3112 9123419 49.47 µM -0.1870344911521 0.418601178155843 no 1984 0.425816795032661 2722 17015854 SGTC_2331 7980721 200 µM -0.18830639077881 0.418064480602877 no 1985 0.425318237928148 2822 2981221 SGTC_401 neomycin 50 µM -0.188958273526902 0.417789467742177 no 1986 0.425062760239159 2772 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis. SGTC_476 mead acid 10 µM -0.18927184460354 0.417657194338677 no 1987 0.42493988060844 2743 5312531 An omega 9 fatty acid. SGTC_174 3553-0389 74.3 µM -0.190465827286013 0.417153623097935 no 1988 0.424472059436263 2880 738071 SGTC_235 0330-0087 5 mM -0.190810126500332 0.417008437499432 no 1989 0.424337177327123 2759 46494818 YHR062C RPP1 SGTC_1754 st042065 16.137 µM -0.191660256640114 0.416649999414559 no 1990 0.424004169687367 2794 1126236 YIL048W NEO1 SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM -0.193114380281321 0.41603706194396 no 1991 0.423434695400503 2908 6728940 SGTC_682 0kpi-0099 17 µM -0.19359006750109 0.415836596059625 no 1992 0.423248438025577 2842 1714895 YML126C ERG13 SGTC_851 0394-0702 453 µM -0.193692727266927 0.415793335668969 no 1993 0.423208243401906 2800 762646 SGTC_768 0384-0033 77.3 µM -0.195578807355613 0.414998731617724 no 1994 0.422469924601376 2768 3965305 YMR134W ERG29 SGTC_382 3229-0966 23.2 µM -0.195607712242847 0.41498655670774 no 1995 0.422458611699941 2921 5722370 SGTC_3234 9132280 49.47 µM -0.196057512380513 0.414797108749222 no 1996 0.422282575510055 2823 17612295 SGTC_1101 ebselen 5.29 µM -0.197537897507432 0.414173736549087 no 1997 0.421703313866337 2891 3194 A potent scavenger of hydrogen peroxide and hydroperoxides. SGTC_1839 st053978 48 µM -0.197598721881121 0.414148128756347 no 1998 0.42167951743942 2763 3788398 SGTC_1949 st076024 69.1 µM -0.19842633633607 0.413799729432651 no 1999 0.421355756834057 2701 2921930 SGTC_59 0330-0160 1.33 µM -0.200104160656845 0.413093627288483 no 2000 0.420699559721368 2770 4293482 SGTC_2842 9000675 19.48 µM -0.200566751956992 0.412898997885757 no 2001 0.420518678920804 2822 2989072 SGTC_2673 kobusone 100 µM -0.202084171512083 0.412260713456481 no 2002 0.419925460944338 2787 6710676 An epoxy ketone and protein crosslinker. SGTC_1170 0310-0127 64.8 µM -0.202329863147356 0.412157387981064 no 2003 0.419829427658396 2843 774975 SGTC_2236 dapsone 200 µM -0.202748397739081 0.411981387524458 no 2004 0.419665846384794 2793 2955 A bacterial DFR inhibitor. An anti-cancer agent. SGTC_2179 6298986 200 µM -0.205434107739983 0.410852426481364 no 2005 0.418616487192912 2900 738374 SGTC_2 0422-0095 29 µM -0.205896256274585 0.410658232585192 no 2006 0.418435974929356 2748 6790840 SGTC_2130 NSC 7 2.4545 µM -0.206268165331188 0.410501973038263 no 2007 0.418290722099913 2895 21448 SGTC_3175 9106517 49.47 µM -0.206538790777471 0.410388277261042 no 2008 0.418185033607801 2863 41468073 SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM -0.206544857765635 0.410385728470468 no 2009 0.418182664309105 2788 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_2743 auranofin 4.32 µM -0.206701792132343 0.41031980039504 no 2010 0.418121378854166 2801 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold. SGTC_3097 9117246 49.47 µM -0.209407191860563 0.409183662829126 no 2011 0.417065189465612 2763 16423892 SGTC_1380 2291-0730 164 µM -0.20973451586699 0.409046254030772 no 2012 0.416937442430946 2867 2999191 SGTC_3009 9080819 71.4286 µM -0.209810413318826 0.409014394297978 no 2013 0.416907822652341 2849 17027216 SGTC_1624 st003710 6.25 µM -0.210003769532702 0.408933231215911 no 2014 0.416832365488621 2961 24207033 SGTC_1929 genistein trimethyl ether 50.5 µM -0.210655876877329 0.408659531859062 no 2015 0.416577903537604 2935 136420 SGTC_2147 5545932 89.7195 µM -0.212585853187606 0.407849752962096 no 2016 0.415825003376644 2805 797404 SGTC_720 r052-1644 49.9 µM -0.213215336913544 0.407585719298982 no 2017 0.415579503088696 2900 1422863 YOR257W CDC31 SGTC_3019 9081971 49.47 µM -0.214565449984069 0.40701956312157 no 2018 0.415053066719531 2935 16451803 SGTC_2826 7992541 19.48 µM -0.214891698261693 0.406882783320099 no 2019 0.41492587876344 2728 2985066 SGTC_55 0767-0285 6.563 µM -0.215219293781616 0.406745450114056 no 2020 0.414798174556583 2907 3116166 SGTC_3275 9138069 49.47 µM -0.217086570773092 0.40596287761635 no 2021 0.414070439697303 2863 17617007 SGTC_2431 5490079 200 µM -0.217124414855298 0.405947021101043 no 2022 0.414055693744066 2837 5722345 SGTC_300 r073-0011 5.04 µM -0.217682344853981 0.405713268637347 no 2023 0.413838310294297 2830 2735780 SGTC_162 k030-0015 37.8 µM -0.217870590407389 0.405634408148312 no 2024 0.413764971082438 2876 1809920 YMR134W ERG29 SGTC_1947 st076332 61.6 µM -0.218726931116068 0.405275715272827 no 2025 0.41343138445491 2879 24208416 SGTC_2681 menadione 3.18 µM -0.218937943195874 0.405187341477204 no 2026 0.413349194505112 2850 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_2492 derrusnin 100 µM -0.221611306467357 0.404068132449791 no 2027 0.412308240026413 2744 1715307 Part of coumarin class of compounds. SGTC_2100 5377183 190 µM -0.222730337085705 0.403599880460581 no 2028 0.411872694403632 2893 2844202 SGTC_3252 9135871 49.47 µM -0.223075431895942 0.403455505341414 no 2029 0.411738399546934 2941 17682838 SGTC_2042 p-Dimethylaminoacetophenone 200 µM -0.224175886316803 0.402995203189589 no 2030 0.411310222965257 2867 75037 A free radical scavenger. SGTC_218 alverine citrate 93.75 µM -0.22476729795653 0.402747880820564 no 2031 0.411080153797293 2928 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_198 3454-2873 16.191 µM -0.225975794745798 0.402242620776122 no 2032 0.410610123203656 2801 710957 SGTC_2104 5389443 200 µM -0.2261640280498 0.402163937049561 no 2033 0.410536923612536 2988 2244536 SGTC_2725 haloperidol 53.21 µM -0.226530116688419 0.402010919064853 no 2034 0.410394569109182 2815 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_1035 k081-0041 55.2 µM -0.228043292993152 0.40137860015093 no 2035 0.409806292073058 2865 731709 SGTC_464 bw-b 70c 158 µM -0.229750987181954 0.400665307184824 no 2036 0.409142636225507 2946 5353454 SGTC_1804 st050076 49.1 µM -0.230280730709505 0.400444103868586 no 2037 0.408936816475213 2930 3895976 SGTC_1505 k297-0037 20.6 µM -0.230812309816513 0.400222166168867 no 2038 0.408730308789508 2824 4089396 SGTC_1782 st039423 80.636 µM -0.231291928144411 0.400021950074722 no 2039 0.408544008551666 2863 2068169 SGTC_216 k038-0035 28.382 µM -0.231659743286005 0.399868423886638 no 2040 0.408401150511719 2871 4444231 YPR107C YTH1 SGTC_878 0828-0289 13.7 µM -0.231962182110604 0.399742197393629 no 2041 0.40828369350971 2839 745350 YLR208W SEC13 SGTC_3158 9100007 49.47 µM -0.232564971733409 0.399490647132585 no 2042 0.408049615011976 2836 19297233 SGTC_366 0181-0206 4.31 µM -0.233035651669857 0.399294256591899 no 2043 0.407866860865433 2978 274874 SGTC_804 1595-0054 20.9 µM -0.233630481197154 0.399046101267055 no 2044 0.407635930977581 2832 761523 Stimulates phospholipase C. SGTC_19 0279-0214 38.434 µM -0.234002013484898 0.398891123406675 no 2045 0.40749170776096 2822 3566274 YBR002C RER2 SGTC_377 3970-0964 33.1 µM -0.234399824877913 0.398725201370994 no 2046 0.407337297293248 2804 16481235 SGTC_2975 9084847 53.72 µM -0.234612695703702 0.398636423191709 no 2047 0.407254677407261 2923 27211724 SGTC_2230 bromochlorosalicylanilide 954.5 nM -0.235321716864437 0.398340762431934 no 2048 0.406979520357426 2871 77254 SGTC_1641 st009299 47.1 µM -0.235483231776219 0.398273419110086 no 2049 0.406916846038656 2835 4046054 SGTC_1316 1272-0050 65.9 µM -0.235735563436503 0.398168215990008 no 2050 0.406818935919672 2817 7340392 SGTC_879 0831-1030 162 µM -0.236217893687681 0.397967141545624 no 2051 0.406631797604405 2844 1549252 SGTC_625 k213-0058 121 µM -0.236776959765946 0.39773411128218 no 2052 0.406414913395365 2875 3655420 SGTC_1009 4106-0057 9.87 µM -0.238346135159024 0.397080241804527 no 2053 0.405806320746519 2841 2928005 SGTC_2514 salinomycin 42.74 µM -0.238433616578213 0.397043797120377 no 2054 0.405772398432832 2994 23682228 A polyether potassium ionophore. SGTC_831 k061-1017 217 µM -0.239372526116029 0.39665270488128 no 2055 0.405408365903797 2879 1240153 SGTC_155 k072-0202 43.6 µM -0.239646336400381 0.396538671836516 no 2056 0.405302220004763 2782 5857737 SGTC_3197 9113331 49.47 µM -0.240009980511908 0.396387239616832 no 2057 0.405161259694595 3040 16610459 YLR208W | YDL195W SEC13 | SEC31 SGTC_1272 0839-0021 27 µM -0.241227746895411 0.395880239420064 no 2058 0.404689303432467 2919 5027250 SGTC_2315 7733312 200 µM -0.241603187019056 0.395723965590958 no 2059 0.404543826177922 2851 726316 SGTC_2477 5967686 25.23 µM -0.24198393380227 0.395565500027559 no 2060 0.404396306151138 2823 776118 SGTC_1052 3253-3998 198 µM -0.243575141978058 0.394903431517721 no 2061 0.4037799411754 2789 5450317 SGTC_987 1497-1013 404 µM -0.243666195403561 0.394865555246077 no 2062 0.403744678241573 2823 1676435 SGTC_1766 st045414 44.774 µM -0.244291598599757 0.394605427800862 no 2063 0.403502494874108 2831 253960 SGTC_885 0865-0106 16.8 µM -0.244527963645482 0.394507127395399 no 2064 0.403410973658687 2839 2793380 SGTC_514 4466-0038 2.65 nM -0.248187262675768 0.392986144671168 no 2065 0.401994760509215 2882 5722064 SGTC_1920 st075728 45.7 µM -0.248319905533146 0.392931042364006 no 2066 0.401943449425862 3049 3400306 SGTC_1481 3346-2004 36 µM -0.248449600200137 0.392877166864312 no 2067 0.401893280443934 2868 2770522 SGTC_2056 5235370 200 µM -0.248579835461417 0.392823068865287 no 2068 0.401842903973947 2878 5511916 SGTC_1278 0874-0585 172 µM -0.248733892018789 0.392759078488949 no 2069 0.401783315263233 2911 766306 SGTC_1028 k015-0029 4.8 µM -0.249973097517669 0.392244456039273 no 2070 0.401304076684237 2827 4588309 SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM -0.252901974323609 0.391028890186335 no 2071 0.400171981884552 2870 6708514 SGTC_2567 aureobasidin a 60 nM -0.253834535870082 0.390642073756975 no 2072 0.399811695637046 3111 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1 SGTC_332 4112-0506 40.9 µM -0.256872217640615 0.389382828358312 no 2073 0.398638709110948 2860 2790355 SGTC_2502 avocadyne acetate 18.59 µM -0.257320789683419 0.389196974632245 no 2074 0.398465572411617 2794 3952079 SGTC_1691 st019933 84.6 µM -0.258151196280094 0.388852984980376 no 2075 0.398145110645331 2908 6176082 SGTC_1751 st044839 27.194 µM -0.258687571169899 0.388630842031495 no 2076 0.397938154998346 2836 5291326 SGTC_433 pimozide 108 µM -0.260358032636043 0.387939243785747 no 2077 0.397293805994806 2822 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic SGTC_2309 7664088 163.95 µM -0.261009388263181 0.387669668107783 no 2078 0.39704263367839 3037 704922 SGTC_1174 0739-0097 51.1 µM -0.262924665692975 0.38687730891111 no 2079 0.396304322249536 2921 728447 SGTC_3253 9135987 49.47 µM -0.263097261925023 0.386805928144034 no 2080 0.396237807146848 2994 4182430 SGTC_3179 9107801 49.47 µM -0.263838672689433 0.386499345856135 no 2081 0.395952116785921 2873 4818259 SGTC_3243 9134147 49.47 µM -0.264754859792518 0.386120589311462 no 2082 0.395599156463774 2925 24282180 SGTC_730 1436-0052 41.2 µM -0.265196838148873 0.385937911921267 no 2083 0.395428915260826 2872 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2 SGTC_346 4513-0042 7.16 µM -0.265345837753 0.385876333474959 no 2084 0.395371528095735 2874 2827372 SGTC_1307 1187-1599 12.2 µM -0.266886475945257 0.385239788511703 no 2085 0.394778284861573 2864 1538471 SGTC_1227 3909-8010 46.6 µM -0.267223648434346 0.385100520231128 no 2086 0.394648484590099 2889 15982272 SGTC_2304 7443016 91.4 µM -0.267905132757127 0.384819080044098 no 2087 0.39438617135482 2813 939854 SGTC_488 nitrendipine 139 µM -0.26825986724585 0.384672605387194 no 2088 0.394249647830505 2871 4507 Dihydropyridine L-type calcium channel blocker. SGTC_2271 7849410 118.62 µM -0.268392283069591 0.384617933324848 no 2089 0.394198689452813 2903 972430 SGTC_835 0312-0010 67.2 µM -0.269578306360176 0.384128348524998 no 2090 0.393742345829634 2860 1626196 SGTC_3174 9107204 49.47 µM -0.269665175099548 0.384092496775921 no 2091 0.393708927258699 3000 3938802 SGTC_2420 aureobasidin a 50 nM -0.270425879741833 0.383778587436385 no 2092 0.393416316190295 3154 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1 SGTC_3093 9117344 49.47 µM -0.270974634723532 0.383552187726849 no 2093 0.393205270598889 3029 24824913 SGTC_1633 st005664 67.9 µM -0.271568894210081 0.383307059068865 no 2094 0.392976759829945 2852 2063822 SGTC_1501 4491-0275 38.4 µM -0.271730533563148 0.383240391831571 no 2095 0.392914610979573 2958 5104718 SGTC_1774 st048371 48.465 µM -0.274485355849029 0.382104714095446 no 2096 0.391855827981053 2881 4242727 SGTC_413 propylparaben 100 µM -0.274756024579866 0.381993185221652 no 2097 0.391751842750002 2876 7175 A pharmaceutical preservative. SGTC_1962 st076595 64.5 µM -0.275408460925686 0.381724389518419 no 2098 0.391501222233056 2888 279619 SGTC_1287 0971-0001 34.6 µM -0.277616543281662 0.380815110644255 no 2099 0.390653365730431 2919 4665869 SGTC_3186 9110464 49.47 µM -0.277884374326268 0.380704863603485 no 2100 0.390550559582451 3017 17018021 SGTC_1627 st003713 25.6 µM -0.277923717493138 0.380688669628469 no 2101 0.390535458469491 2975 16195070 YER133W GLC7 SGTC_579 4491-1009 110 µM -0.278665556896763 0.380383361514199 no 2102 0.390250748709412 3003 1271041 SGTC_2113 5491891 107.031 µM -0.278681146534311 0.380376946311147 no 2103 0.390244766209763 2902 789979 SGTC_181 1447-1644 8.07 µM -0.281462578199209 0.379232903349367 no 2104 0.389177813310496 3008 534600 SGTC_293 4049-0273 38.5 µM -0.285702981079582 0.377490801088554 no 2105 0.387552810630402 2952 1380311 SGTC_2376 9072922 81.32 µM -0.285946187468011 0.377390958759586 no 2106 0.387459668739785 3035 17087968 SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM -0.286086279711769 0.377333451094987 no 2107 0.38740601989627 3010 616764 SGTC_2803 7707263 71.43 µM -0.287348844101685 0.376815293090473 no 2108 0.386922613312716 2929 2199229 SGTC_2902 5787006 60.46 µM -0.287997404916133 0.376549209095056 no 2109 0.386674362565242 2915 591003 SGTC_2664 lyso-paf C-16 73.48 µM -0.288081744231689 0.376514611646921 no 2110 0.386642083263842 2918 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_103 0844-0104 51.839 µM -0.288472541818428 0.376354312658673 no 2111 0.386492523009557 3018 5375804 SGTC_1484 3473-2379 286 µM -0.292402236433062 0.374743603666906 no 2112 0.384989549244156 2952 671917 SGTC_651 3253-0966 34.4 µM -0.292439029176718 0.37472853327392 no 2113 0.384975485400898 2927 781462 SGTC_1528 arabinosylhypoxanthine 74.6 µM -0.29256288229941 0.374677804154209 no 2114 0.384928144272929 3134 804 An inhibitor of viral and cellular DNA polymerases. SGTC_1122 capsaicin 818.572 nM -0.2941291693919 0.374036454525781 no 2115 0.384329601124778 3059 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_1690 st023502 41.2 µM -0.294194165599667 0.374009847962803 no 2116 0.384304769330747 3010 24207482 SGTC_1694 st024011 44.9 µM -0.294441292066926 0.373908690835033 no 2117 0.384210359026675 2990 2787533 SGTC_592 k241-0073 46.5 µM -0.294647695246654 0.37382420976557 no 2118 0.384131511600175 3043 4230158 SGTC_2760 etidronate 98.04 µM -0.297482549214401 0.372664515563113 no 2119 0.383049064503407 2954 3305 A chelator and antioxidant. SGTC_1232 0279-0259 161 µM -0.298853813456641 0.372103966110259 no 2120 0.382525794462674 2971 1560000 SGTC_2667 digitoxin 100 µM -0.298863168957059 0.372100142670328 no 2121 0.382522225169027 3005 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_620 0109-0052 432 µM -0.29887815749027 0.372094017128356 no 2122 0.38251650679167 3075 493037 SGTC_1500 4488-1866 171 µM -0.299154985277512 0.371980888448307 no 2123 0.382410896944668 3060 2900003 SGTC_950 1165-0508 94.1 µM -0.299383654263585 0.371887448718913 no 2124 0.38232366628384 3016 6148369 SGTC_2540 epiandrosterone 100 µM -0.300209876452046 0.371549897085597 no 2125 0.382008536009932 2954 441302 A steroid. SGTC_2077 5212015 200 µM -0.300778218740631 0.371317759145152 no 2126 0.38179180933953 2878 780900 SGTC_2154 5570129 200 µM -0.303121454318637 0.370361165745855 no 2127 0.380898652331849 2946 673366 SGTC_735 3076-0345 636 µM -0.304043947103415 0.369984790319765 no 2128 0.380547205035402 3102 2888990 SGTC_1618 st003135 44.5 µM -0.304103520678411 0.369960488681906 no 2129 0.380524512338462 2970 1270615 SGTC_1898 st060199 18.6 µM -0.305029236443163 0.369582931499918 no 2130 0.380171942638553 2926 688866 SGTC_1391 3442-0225 151 µM -0.305186158425183 0.369518942642108 no 2131 0.380112186921785 2938 5227075 SGTC_1797 st048695 56.8 µM -0.305387803457356 0.369436722149423 no 2132 0.380035404918534 3067 592262 YIL048W NEO1 SGTC_1845 st056753 3.01 µM -0.305836340222549 0.369253853299903 no 2133 0.379864628921006 2888 5375839 SGTC_3314 9135860 59.4275 µM -0.306549381072989 0.368963206800352 no 2134 0.37959319380534 3112 25252478 SGTC_209 4077-0173 175.592 µM -0.307333287941747 0.368643760668178 no 2135 0.379294850404272 3017 15993494 SGTC_1348 1493-0373 93.8 µM -0.308633956397647 0.368113931787871 no 2136 0.378799993788564 3006 3010129 SGTC_2078 5212016 200 µM -0.308919829406333 0.367997514649329 no 2137 0.37869125619671 2964 1899708 SGTC_1630 st005209 31.3 µM -0.308933739532412 0.367991850285673 no 2138 0.378685965443299 2990 3367314 SGTC_2080 5212524 12.4 µM -0.308936559769806 0.367990701856003 no 2139 0.378684892761286 3028 260183 SGTC_426 0988-0037 14.6 µM -0.309040840385985 0.367948238545135 no 2140 0.378645230110607 3159 5383008 SGTC_3285 9112818 20.8695 µM -0.309224873454896 0.367873303785966 no 2141 0.378575237101461 2930 17017947 YPR165W RHO1 SGTC_2021 4019055 173 µM -0.309635796637466 0.367706001848242 no 2142 0.378418965709528 3106 44827708 YER133W GLC7 SGTC_494 Boc-Gly-Val-Val-CHO 140 µM -0.310145488638349 0.3674985223693 no 2143 0.378225160811015 2964 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA. SGTC_2952 9073731 13.78 µM -0.311170206894534 0.367081509087259 no 2144 0.377835615472704 2979 16457353 SGTC_3312 9133330 71.43 µM -0.311932879707345 0.366771237997072 no 2145 0.377545766969018 3097 17617324 SGTC_530 4358-1714 28 µM -0.31208929886697 0.366707614192384 no 2146 0.377486329469597 3038 1564641 SGTC_1153 4055-0057 267 µM -0.312506836769243 0.366537797757818 no 2147 0.377327684034735 2945 882706 SGTC_886 0866-0150 153 µM -0.312786939684167 0.366423892012445 no 2148 0.377221269250756 3129 271463 SGTC_1120 ficusin 1.78878 µM -0.312923275865868 0.366368454238382 no 2149 0.377169476713695 3101 6199 A DNA cross-linker. SGTC_1025 k007-0731 70 µM -0.313688288576108 0.366057432282363 no 2150 0.376878898250582 2952 6256118 SGTC_2738 aclarubicin 5.55 µM -0.314711355448009 0.365641633915341 no 2151 0.376490410827736 3019 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31 SGTC_1228 0124-0032 52.5 µM -0.315956787864194 0.365135674003798 no 2152 0.376017653744227 3040 X1228 SGTC_178 4092-0806 87.505 µM -0.316953127518897 0.364731077545899 no 2153 0.375639584343838 3047 2169044 SGTC_1097 itavastatin 7.23 µM -0.317699278622617 0.364428176970004 no 2154 0.375356529232625 3008 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49 SGTC_2714 st079313 56.9 µM -0.31794490148003 0.364328484702366 no 2155 0.375263365987001 2962 2939799 SGTC_1225 1216-0074 20.6 µM -0.319457625026115 0.363714710022951 no 2156 0.374689759779298 2990 4241466 SGTC_337 1315-0038 354 µM -0.319619355732722 0.36364910982575 no 2157 0.374628449857297 2983 1626437 SGTC_1649 st011737 51.3 µM -0.320743022357569 0.363193445658806 no 2158 0.374202570625766 3033 1761035 SGTC_2238 6671620 73.2395 µM -0.321166231126271 0.36302187811066 no 2159 0.374042210651994 2895 729941 SGTC_1564 D-Arginine 115 µM -0.321295552318085 0.362969457173899 no 2160 0.373993213312917 3006 71070 D-isomer of arginine; arginine decarboxylase inhibitor. SGTC_1507 4075-3230 155 µM -0.321439242201917 0.362911214833231 no 2161 0.373938774337522 2981 659771 SGTC_629 3448-6466 76.7 µM -0.32324451697254 0.36217974684939 no 2162 0.373255034638561 3009 573744 SGTC_2212 7123476 200 µM -0.323828838864369 0.361943096741595 no 2163 0.373033810701424 2995 1085715 SGTC_3062 9077494 49.47 µM -0.323891950960266 0.361917539527012 no 2164 0.373009919001043 3097 16459633 SGTC_1145 3546-0597 10.2 µM -0.324676517107873 0.361599881260629 no 2165 0.372712954621202 3022 875334 SGTC_3078 9116413 49.47 µM -0.324799996808248 0.361549894987594 no 2166 0.372666223480281 2889 17177322 SGTC_2073 5212005 126 µM -0.325014265589629 0.361463161659551 no 2167 0.372585137477201 2932 691789 SGTC_339 3091-4833 71.4 µM -0.325890182851588 0.361108675360836 no 2168 0.372253721770207 2982 3240077 SGTC_2844 9010103 25.97 µM -0.327038922254361 0.360643957914117 no 2169 0.371819223347635 3151 2480525 SGTC_596 1155-0152 116 µM -0.327753981591969 0.360354787659741 no 2170 0.371548842162994 3008 280313 SGTC_1098 clofazimine 15.1 µM -0.327892922482391 0.360298609174833 no 2171 0.371496312608594 3109 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2 SGTC_1300 1094-0077 113 µM -0.327954134543663 0.360273860032399 no 2172 0.371473170848167 2982 5532636 SGTC_2704 st078022 71.1 µM -0.328363954600484 0.36010817746557 no 2173 0.371318246726591 3147 54697681 SGTC_3066 9117245 49.47 µM -0.329012925332557 0.359845864520056 no 2174 0.371072959218587 3031 17176980 SGTC_677 0929-0063 136 µM -0.329075002126939 0.359820776634353 no 2175 0.371049499174106 3015 1539583 SGTC_1603 st002045 67.8 µM -0.329091820284306 0.359813979802146 no 2176 0.371043143343359 3116 5887985 SGTC_3255 9139072 49.47 µM -0.329549687045961 0.359628956144768 no 2177 0.370870122233738 3071 17646060 SGTC_454 lyso-paf C-16 6.67 µM -0.329628836116737 0.359596975391137 no 2178 0.370840215610402 3056 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_1686 st019653 115.5 µM -0.329977712950992 0.359456020908466 no 2179 0.370708401152503 3115 97252 SGTC_2285 7945142 200 µM -0.33143752035939 0.358866431826067 no 2180 0.370157013879102 3102 2970608 SGTC_881 0833-0569 170 µM -0.331501924200178 0.35884042804249 no 2181 0.370132693889024 3002 5418700 SGTC_1634 st006576 41 µM -0.331591181053764 0.358804390653822 no 2182 0.370098989835363 3178 3915356 SGTC_2011 4012611 177 µM -0.332013164964575 0.358634031983791 no 2183 0.369939659073229 2963 2049887 SGTC_2257 7960413 200 µM -0.332017569156004 0.358632254120651 no 2184 0.369937996276353 2979 2974689 YIL048W NEO1 SGTC_849 0386-0493 241 µM -0.332275509436726 0.35852813535441 no 2185 0.369840615493429 2971 726119 SGTC_762 1165-0429 115 µM -0.332335458110756 0.358503938305395 no 2186 0.36981798412873 3118 5967793 SGTC_1993 st073995 70.8 µM -0.333030815278489 0.358223313220534 no 2187 0.369555511176362 3008 3098394 SGTC_985 1493-0307 8.71 µM -0.333672776927856 0.357964304917861 no 2188 0.369313247111768 3139 3278274 SGTC_1903 st060211 78.3 µM -0.33379377838161 0.357915492526675 no 2189 0.369267589283541 3157 688960 SGTC_1719 st032227 49.2 µM -0.334388828536463 0.357675481119177 no 2190 0.369043084132813 2988 3125804 SGTC_3141 9094609 49.47 µM -0.334694563015691 0.357552186057506 no 2191 0.368927751616709 2940 25236309 YDL196W YDL196W SGTC_9 0092-0002 10.449 µM -0.338476132393402 0.356028406450958 no 2192 0.367502205196405 3055 759368 SGTC_2565 isoliquiritigenin 100 µM -0.338537588399051 0.356003661716487 no 2193 0.367479053001626 3133 638278 Binds to benzodiazepine receptor 65X better than valium. SGTC_2945 9067681 61.76 µM -0.338552367587166 0.355997711093401 no 2194 0.367473485340287 3007 16456930 SGTC_1030 k029-0042 36.7 µM -0.338689950760921 0.35594231693213 no 2195 0.367421655919564 3052 6080581 SGTC_269 exalamide 29 µM -0.339219409661115 0.355729172937261 no 2196 0.367222224211784 3013 3316 A derivative of salicylamide. SGTC_445 e6 berbamine 66 µM -0.339470988319121 0.35562791084848 no 2197 0.367127474426431 3093 6610268 A calcium/calmodulin antagonist. SGTC_217 ketoconazole 989 nM -0.340172554133295 0.355345579766871 no 2198 0.366863292826576 3081 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4 SGTC_823 0417-1665 178 µM -0.340722396205279 0.355124362331298 no 2199 0.366656288372744 3086 3429856 SGTC_2995 9067767 71.4286 µM -0.341247244136623 0.354913246304309 no 2200 0.366458729881457 3068 11673567 SGTC_908 3448-7491 47.7 µM -0.34202866368765 0.354599008864731 no 2201 0.366164660596891 2980 1203031 SGTC_2768 sulfasalazine 50.2 µM -0.342591464855505 0.354372747159312 no 2202 0.365952911987686 3151 5384001 An antioxidant and salicylic acid derivative. SGTC_2295 7971645 200 µM -0.343003261511888 0.354207226013843 no 2203 0.365798003255405 3042 2978226 YKL099C UTP11 SGTC_2870 9038528 12.99 µM -0.343614519675475 0.353961582354583 no 2204 0.365568101894307 3121 6463316 SGTC_1927 st060202 13.8 µM -0.343966978929426 0.353819968704655 no 2205 0.36543555977897 3092 688887 SGTC_2106 5357045 167.29 µM -0.344078994565572 0.353774966479293 no 2206 0.365393439722472 3100 668842 SGTC_1090 efavirenz 20.7 µM -0.345161252411794 0.353340275251628 no 2207 0.36498657341637 3058 64139 A non-nucleoside reverse transcriptase inhibitor. SGTC_3054 9094397 49.47 µM -0.347581262852395 0.352368965430395 no 2208 0.364077339984966 3040 2598354 SGTC_2487 5918373 44.05 µM -0.348199742133098 0.352120882996885 no 2209 0.363845090712782 3146 2876279 SGTC_2375 9072683 200 µM -0.34942634871408 0.351629056711208 no 2210 0.363384627530998 3191 16798029 SGTC_404 fumagillin 50 µM -0.34960963580004 0.351555586306891 no 2211 0.363315839225556 3093 12015870 A methionine aminopeptidase binder. SGTC_1758 st042942 75.2445 µM -0.349831646634428 0.351466600961423 no 2212 0.363232523660613 3074 669317 SGTC_1919 st067113 52.3 µM -0.35029900900845 0.351279301566786 no 2213 0.363057154452841 3150 1268243 SGTC_3144 9087057 49.47 µM -0.350308279992405 0.351275586507291 no 2214 0.363053675975462 3168 17249618 SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM -0.350393487160797 0.351241443040812 no 2215 0.363021706736371 3107 17037758 SGTC_654 1124-0271 80.9 µM -0.351667562788307 0.350731050001603 no 2216 0.362543794844255 3046 5403748 SGTC_1864 st057645 30.4 µM -0.353482485904013 0.350004459338377 no 2217 0.361863378312035 3101 688666 SGTC_1567 st069303 68.4 µM -0.35360195002769 0.349956652008901 no 2218 0.361818606375686 3124 5581319 SGTC_799 1310-0557 151 µM -0.354937289839729 0.349422435775466 no 2219 0.361318285822529 3183 5354492 SGTC_1185 1319-0113 81.3 µM -0.355403696403958 0.349235915294617 no 2220 0.361143590030769 3139 4672763 SGTC_1016 4226-1401 38 µM -0.357049470866885 0.34857804538374 no 2221 0.360527385444257 3091 2901613 SGTC_2874 9043904 71.43 µM -0.357458793297685 0.348414496411002 no 2222 0.360374184658218 3086 4463428 SGTC_188 3229-0966 278.469 µM -0.360562039979701 0.34717548091705 no 2223 0.359213435343144 3161 5722370 SGTC_2529 gangaleoidin 93.61 µM -0.360597914183025 0.347161167145492 no 2224 0.359200024400705 3012 4565183 SGTC_552 k242-0005 476 µM -0.363422378006639 0.346034894704083 no 2225 0.358144693830376 3174 4088318 SGTC_706 4262-0057 46.9 µM -0.363908511309027 0.345841183013985 no 2226 0.357963164352788 3042 883298 SGTC_1337 1486-1011 40.3 µM -0.365134481218596 0.345352844621043 no 2227 0.3575055114583 3098 X1337 SGTC_12 0849-0099 9.267 µM -0.36675974810278 0.344705851764779 no 2228 0.356899117395243 3110 6071388 SGTC_1447 4239-0816 81.9 µM -0.367274595093441 0.344500993964145 no 2229 0.356707101068002 3049 1341554 SGTC_1743 st037606 46.3785 µM -0.368276580002956 0.344102434591431 no 2230 0.35633350685725 3051 590142 YLR208W | YDL195W SEC13 | SEC31 SGTC_1206 3978-0017 132 µM -0.368543190044332 0.343996414301375 no 2231 0.356234123405924 3303 3873677 SGTC_3042 9091578 49.47 µM -0.369507729212939 0.343612957636127 no 2232 0.355874656549212 3147 25236497 SGTC_975 1335-0046 28.5 µM -0.369925731461372 0.343446828997273 no 2233 0.355718914198836 3067 16486740 SGTC_601 0986-0029 62.9 µM -0.37394958289336 0.341849161205857 no 2234 0.354220913147823 3084 24747981 SGTC_2510 benzyl isothiocyanate 8.31 µM -0.374923030959328 0.341463078016306 no 2235 0.35385885507015 3065 2346 DNA damaging agent; causes G2/M arrest. SGTC_2511 berberine 10.47 µM -0.375036455128972 0.341418103175779 no 2236 0.353816677394533 3064 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_3321 9137793 26.8275 µM -0.375417811906853 0.341266904477609 no 2237 0.353674880016608 3143 4904192 SGTC_2181 6316240 54.2555 µM -0.375888206099017 0.341080439705514 no 2238 0.353500004407304 3146 12779990 SGTC_2822 7994718 71.43 µM -0.376662494332548 0.340773595528011 no 2239 0.353212219291843 3088 1018011 SGTC_1553 gossypol 38.6 µM -0.376669470788435 0.340770831293321 no 2240 0.353209626685004 3048 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_694 1315-0438 43.2 µM -0.377356775797602 0.34049854693776 no 2241 0.352954242206461 3095 6793154 SGTC_3027 9089541 49.47 µM -0.379215003933492 0.339762803402884 no 2242 0.352264105340876 3166 9943819 SGTC_942 3253-1115 227 µM -0.381306389353403 0.33893547368355 no 2243 0.351487956569199 3269 46497897 SGTC_1709 st033179 39.1045 µM -0.381626543675066 0.338808892469476 no 2244 0.351369196377347 3065 573381 SGTC_2497 7-hydroxyflavone 100 µM -0.381815170572881 0.338734322512335 no 2245 0.351299232642269 3222 5281894 SGTC_2624 nerol 100 µM -0.384235525263512 0.337778044366131 no 2246 0.35040194505146 3054 637566 A natural product oil. SGTC_2907 7721985 69.9 µM -0.38513083099662 0.337424575297804 no 2247 0.350070243333316 3151 3267881 SGTC_2473 5854593 8.94 µM -0.386700187441842 0.336805335388771 no 2248 0.349489088685814 3015 2872951 SGTC_1142 3253-1408 9.78 µM -0.387327931229974 0.336557762650299 no 2249 0.34925672503281 3218 256655 SGTC_964 1287-0107 19.4 µM -0.388432470263511 0.336122321025651 no 2250 0.348848009554775 3240 51516812 YPR165W RHO1 SGTC_841 0251-0215 91.2 µM -0.38903100382996 0.335886453358245 no 2251 0.348626605821967 3149 3888614 SGTC_469 w7 172 µM -0.389715494252754 0.335616791375091 no 2252 0.348373468949637 3142 45115570 A P450 inhibitor. SGTC_2970 9090938 41.86 µM -0.390092265385701 0.335468394651431 no 2253 0.348234161010434 3274 17217104 SGTC_2601 securinine 100 µM -0.390168182660343 0.33543849664793 no 2254 0.34820609371804 3069 442872 A GABA receptor antagonist. SGTC_818 4072-2707 53.5 µM -0.390604265397797 0.335266777227147 no 2255 0.348044886154649 3029 882871 SGTC_114 0364-0001 490.298 µM -0.390867293099807 0.33516321956357 no 2256 0.34794766545995 3151 4003655 SGTC_2992 9074591 71.4286 µM -0.392758809713442 0.33441887255675 no 2257 0.347248814965587 3210 17741321 SGTC_1662 st014054 52 µM -0.394425104176911 0.333763693415773 no 2258 0.346633606234336 3128 2838777 SGTC_2232 chlorophetanol 41.5365 µM -0.394763604669227 0.333630658452323 no 2259 0.346508678598389 3199 15907 An antifungal of unknown mechanism. YFR051C RET2 SGTC_125 0133-0007 11.75 µM -0.394766454030226 0.333629538706257 no 2260 0.346507627078626 3245 26541 SGTC_2553 4-methylesculetin 85.09 µM -0.396232944467604 0.333053432000302 no 2261 0.34596659490224 3161 5319502 SGTC_1192 1488-0095 21.4 µM -0.397175988642958 0.3326831676445 no 2262 0.34561884367991 3176 915875 SGTC_533 1222-0222 6.71 µM -0.398008887989577 0.332356284750058 no 2263 0.345311817085238 3270 3982874 SGTC_894 0960-0238 55.9 µM -0.398437966072621 0.332187936842612 no 2264 0.34515368835881 3229 6741907 YDL195W SEC31 SGTC_686 1319-0111 510 µM -0.399705311153528 0.331690894399627 no 2265 0.34468678988742 3259 4562600 SGTC_688 0527-0193 473 µM -0.400151885381669 0.331515822136837 no 2266 0.344522325238176 3098 4007154 SGTC_3317 9138495 8.753 µM -0.400679055064854 0.331309201086308 no 2267 0.344328216664843 3133 17020139 SGTC_3015 9080845 49.47 µM -0.40089090444662 0.331226182427807 no 2268 0.344250223380561 3239 5296973 SGTC_2112 5488546 200 µM -0.406534951745016 0.329017481749718 no 2269 0.342174790589543 3100 600757 SGTC_1579 chlormadinone acetate 49.4 µM -0.406916262102738 0.328868476467612 no 2270 0.342034745808956 3230 45114258 A steroidal progestin. SGTC_1463 k081-0032 34.1 µM -0.407022914565472 0.328826804573523 no 2271 0.34199557918792 3182 977755 SGTC_2852 9023854 51.95 µM -0.408799544122909 0.328132942453141 no 2272 0.34134338724282 3276 19798528 SGTC_1931 st074438 57.1 µM -0.410535532114781 0.327455525225401 no 2273 0.340706571984942 3166 2787313 SGTC_778 3456-2434 196 µM -0.411390526755169 0.32712209773324 no 2274 0.340393099579255 3237 5539063 SGTC_2770 toltrazuril 17.5 µM -0.412810841684704 0.32656851379528 no 2275 0.339872603780005 3241 68591 Kills coccidiodes. SGTC_1836 st055642 81 µM -0.413061267504645 0.326470947024178 no 2276 0.339780863079883 3140 8571 SGTC_1613 st002381 52.1 µM -0.413550529327488 0.326280363169795 no 2277 0.339601654864024 3217 551167 SGTC_485 niflumic acid 177 µM -0.413902124604284 0.326143433045099 no 2278 0.339472893930312 3239 4488 A COX2 inhibitor. SGTC_1668 st014914 51.6 µM -0.413939844411065 0.326128744313853 no 2279 0.339459081326275 3205 2839556 SGTC_482 fipronil 114 µM -0.415903611854605 0.325364393083116 no 2280 0.338740268221764 3199 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels. SGTC_2633 5,7-dihydroxyisoflavone 100 µM -0.416175670235188 0.325258558443672 no 2281 0.338640730802094 3267 5377381 SGTC_73 0327-0325 16.231 µM -0.416777212122347 0.325024600000768 no 2282 0.338420685969055 3224 53298 SGTC_957 1187-1561 14.1 µM -0.416865143592253 0.324990406479982 no 2283 0.338388525138188 3239 1538454 SGTC_1132 3456-3614 2.5 µM -0.418649822022177 0.324296725412204 no 2284 0.337736036173495 3352 3125502 SGTC_2270 7924575 90.91 µM -0.419414203969486 0.32399980643223 no 2285 0.337456722583798 3276 1262135 SGTC_925 2064-1272 59.6 µM -0.422100940822543 0.322957050933494 no 2286 0.336475670625917 3149 6815817 SGTC_333 3486-0131 40.1 µM -0.422298834423007 0.322880300870163 no 2287 0.336403454410729 3291 6744690 SGTC_3162 9099653 49.47 µM -0.423152902008185 0.322549150129202 no 2288 0.336091853513875 3272 25237511 SGTC_714 4296-0578 26.1 µM -0.423481934558703 0.322421610672694 no 2289 0.335971838202625 3128 1589775 SGTC_471 1-acyl-paf 4 µM -0.423705786416818 0.322334853255069 no 2290 0.335890197326363 3149 16759367 SGTC_1386 3228-0095 33.8 µM -0.424061957079686 0.322196833486813 no 2291 0.335760314501063 3267 870181 SGTC_2990 9074105 71.4286 µM -0.425698506426466 0.321562969231964 no 2292 0.335163775264699 3214 6502001 SGTC_33 0986-0033 35.816 µM -0.426370090260079 0.321303003163749 no 2293 0.334919096131154 3223 2848082 SGTC_88 0180-0332 8.668 µM -0.426828124190545 0.32112575117469 no 2294 0.334752260125834 3137 3101745 SGTC_2606 farnesol 9.78 µM -0.427044478742467 0.321042039502997 no 2295 0.334673465667513 3296 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_2865 9030313 51.95 µM -0.427426868119208 0.320894108058267 no 2296 0.334534220565826 3094 42562754 SGTC_544 k015-0020 52.4 µM -0.430151028919356 0.319841060986991 no 2297 0.333542891107294 3200 3008304 SGTC_2087 5276107 200 µM -0.43076809127704 0.319602731549128 no 2298 0.333318501508325 3131 144405 SGTC_1822 st052468 42 µM -0.431859213587635 0.319181487163855 no 2299 0.332921869951513 3214 2873678 SGTC_1018 4259-0013 28.1 µM -0.434762596143408 0.318061729817194 no 2300 0.331867378655052 3267 6801262 SGTC_2893 9048488 25.97 µM -0.434906618045248 0.318006227565187 no 2301 0.331815105325884 3193 6467338 SGTC_2862 9027634 71.43 µM -0.435305927587843 0.317852365551798 no 2302 0.331670191445269 3131 5012562 SGTC_1575 cyproterone acetate 48 µM -0.436809225075524 0.31727339692193 no 2303 0.331124854100158 3194 9880 An androgen receptor antagonist and liver toxin. SGTC_1729 st035615 45.989 µM -0.436997719825184 0.317200832979794 no 2304 0.331056500837492 3243 17385451 SGTC_2724 maprotiline 69.64 µM -0.437180213789158 0.317130585827229 no 2305 0.330990328985132 3296 4011 A tricyclic antidepressant. SGTC_2391 6285546 200 µM -0.437421564281786 0.317037693230987 no 2306 0.330902824011409 3150 846083 SGTC_2744 captopril 92.04 µM -0.437459475675256 0.317023102687241 no 2307 0.330889079548456 3225 44093 angiotensin-converting enzyme (ACE) inhibitor  SGTC_909 3448-9333 149 µM -0.438627502080387 0.316573716626699 no 2308 0.330465732985215 3155 3344074 SGTC_2293 7624732 200 µM -0.439306081762341 0.316312764358662 no 2309 0.330219884006468 3171 894453 SGTC_489 paxilline 115 µM -0.440235302570955 0.31595557476359 no 2310 0.329883346803458 3241 105008 A toxic potassium channel blocker. SGTC_2070 5230947 200 µM -0.44349236697332 0.314704927164159 no 2311 0.32870481952904 3294 2835538 SGTC_1058 3448-5425 97.3 µM -0.443956060719593 0.314527050313047 no 2312 0.328537175949504 3236 7279705 SGTC_1051 3253-3903 78 µM -0.44415182474403 0.314451966493844 no 2313 0.328466409890693 3124 5509239 SGTC_1727 st034309 9.9045 µM -0.445565378813601 0.313910036392954 no 2314 0.327955611874262 3372 870305 SGTC_661 1304-0007 33.6 µM -0.446078596290996 0.313713377642748 no 2315 0.327770236554836 3227 3117130 SGTC_2868 9035608 32.47 µM -0.447139467271044 0.313307032476716 no 2316 0.327387182105431 3161 6462614 SGTC_2555 cholic acid 100 µM -0.4472112253065 0.313279555187738 no 2317 0.327361278597206 3345 6708657 Influences liver metabolism. SGTC_2897 9048598 12.99 µM -0.447962514632711 0.312991936858641 no 2318 0.327090125044088 3187 6467404 SGTC_132 0417-1715 25.805 µM -0.44873023300142 0.312698146475105 no 2319 0.326813136216931 3352 6769098 SGTC_1073 triclabendazole 3.09 µM -0.450676283975947 0.311953965157553 no 2320 0.326111438795517 3287 50248 An antihelmetic and likely tubulin inhibitor. SGTC_1849 st056239 19.2 µM -0.452379206024199 0.311303386770886 no 2321 0.325497912193202 3167 5393181 SGTC_3016 9080866 49.47 µM -0.454984860618928 0.310309071972139 no 2322 0.324560065256656 3197 17066299 SGTC_2069 5228469 200 µM -0.455551058062434 0.310093194592476 no 2323 0.324356421972474 3278 2835210 SGTC_992 3909-8734 162 µM -0.457637500478023 0.309298249937923 no 2324 0.32360644848462 3234 4288319 SGTC_2832 7992762 51.95 µM -0.457639763596135 0.309297388162515 no 2325 0.323605635393042 3083 2985177 SGTC_2086 5274770 176.623 µM -0.458557835289805 0.308947881135819 no 2326 0.323275860701205 3263 689278 SGTC_2444 5485484 36.41 µM -0.459181623696705 0.308710505467024 no 2327 0.32305187281767 3297 6790631 SGTC_205 1486-1330 71.903 µM -0.459802828109061 0.308474192511084 no 2328 0.322828876536382 3229 4118834 SGTC_484 loperamide 105 µM -0.46269682593624 0.307374330843614 no 2329 0.321790846866523 3221 3955 An opioid-receptor agonist. SGTC_2996 9066192 71.4286 µM -0.464238695957988 0.306789049999893 no 2330 0.321238370053642 3243 6472854 SGTC_1573 oleylamine 1.06 µM -0.464293739553886 0.306768165006589 no 2331 0.321218654350536 3252 5356789 An amine of the fatty acid oleic acid. SGTC_2496 diffractaic acid 79.83 µM -0.465277883739055 0.306394860642424 no 2332 0.32086623530925 3420 94870 An apoptosis inducer which activates caspases. SGTC_1547 harmine 94.2 µM -0.466631406682927 0.30588177209053 no 2333 0.320381806442955 3273 5280953 A monoamine oxidase inhibitor YHR072W ERG7 SGTC_2003 4023581 200 µM -0.467143248708313 0.305687844035374 no 2334 0.320198696710664 3328 16641307 SGTC_2614 arthonioic acid 13.39 µM -0.467160012804639 0.305681493331617 no 2335 0.320192700152773 3277 6710684 SGTC_1435 4092-0789 56.7 µM -0.467559218800325 0.305530280320851 no 2336 0.320049917077848 3305 2248285 SGTC_1984 st072354 53.1 µM -0.467806271965664 0.305436717043129 no 2337 0.319961567497631 3163 5762938 SGTC_980 1473-0395 201 µM -0.468073930831832 0.305335364373293 no 2338 0.319865860561137 3191 768876 SGTC_2214 7179297 48.276 µM -0.468292260050407 0.3052527020946 no 2339 0.319787801334034 3268 769744 SGTC_3187 9109394 49.47 µM -0.468863494386626 0.305036472346627 no 2340 0.319583605732742 3245 17098090 SGTC_1164 k060-0068 93.7 µM -0.469518020867258 0.304788797618295 no 2341 0.319349703431242 3232 5963676 SGTC_3198 9112019 49.47 µM -0.469554731048744 0.304774909026258 no 2342 0.319336586768279 3278 45595555 SGTC_1959 st077091 55.8 µM -0.470397500739436 0.304456140699741 no 2343 0.319035524718897 3187 821356 YKL052C ASK1 SGTC_297 0986-0032 24 µM -0.47457269474909 0.302879113186606 no 2344 0.317545786153036 3241 2847425 SGTC_696 1560-0013 611 µM -0.476391288475492 0.302193350876314 no 2345 0.316897819909573 3409 1650269 SGTC_1502 4534-4282 27.7 µM -0.477920585147439 0.301617217815705 no 2346 0.316353364680714 3267 3278949 SGTC_2022 5136654 200 µM -0.477925617108067 0.301615322937173 no 2347 0.316351573874502 3335 1713771 SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM -0.478137963979857 0.30153536464722 no 2348 0.31627600644269 3267 2724278 An inhibitor of dopamine biosynthesis. SGTC_2923 7992654 58.14 µM -0.478138837273559 0.301535035831972 no 2349 0.316275695681348 3266 2985126 SGTC_1678 st019265 80.2 µM -0.478348498975738 0.30145609802788 no 2350 0.316201091373456 3419 5367020 SGTC_1100 amiodarone 5.07 µM -0.478397328079982 0.301437715165092 no 2351 0.316183717497815 3348 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. SGTC_2210 7115885 190.385 µM -0.47851378685951 0.301393873559928 no 2352 0.316142281956736 3295 2927039 SGTC_2223 6903751 107.57 µM -0.478645919295905 0.301344134988898 no 2353 0.316095272590946 3308 5598863 SGTC_2726 cimetidine 79.27 µM -0.478654347943936 0.301340962320995 no 2354 0.31609227399286 3275 2756 A P450 inhibitor, histamine H2-receptor antagonist. SGTC_2968 9090663 33.37 µM -0.47901485688626 0.301205275498991 no 2355 0.315964029706002 3237 25236811 SGTC_1588 farnesol 29.9 µM -0.479902677840639 0.300871238633556 no 2356 0.315648298517769 3268 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_1721 st082152 9.2685 µM -0.480195498875661 0.300761103274048 no 2357 0.315544193568192 3282 5296051 SGTC_3316 9136639 10.545 µM -0.481435369635025 0.30029496686669 no 2358 0.315103551855003 3339 4903665 SGTC_2710 st078562 53.7235 µM -0.481565997010055 0.300245875786813 no 2359 0.315057143067979 3246 17250908 SGTC_1560 lithocholic acid 53.1 µM -0.484729144467913 0.299058242533374 no 2360 0.313934244979241 3307 9903 A bile acid which acts as a detergent. SGTC_785 1270-0111 65.3 µM -0.485854646003283 0.298636177544736 no 2361 0.313535113318535 3252 6741994 SGTC_2949 9072542 2.23 µM -0.486160747371426 0.298521435879336 no 2362 0.313426599661242 3329 16457352 SGTC_1581 himbacine 57.9 µM -0.486450265538265 0.298412928862158 no 2363 0.313323979646534 3248 5281825 An alkaloid muscarinic receptor antagonist. SGTC_1160 4092-0570 10.5 µM -0.487775328919819 0.297916544431093 no 2364 0.312854494085246 3257 4994975 SGTC_306 1672-3436 11.6 µM -0.488697934683578 0.297571147848214 no 2365 0.312527783096421 3353 6797378 SGTC_113 0099-0221 2.5 µM -0.488821966546533 0.297524727892835 no 2366 0.312483872449666 3415 89219 SGTC_2513 baicalein 25.65 µM -0.489418400955978 0.297301553546813 no 2367 0.312272755666536 3292 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2 SGTC_522 1273-0010 11.6 µM -0.489603889322435 0.297232162944908 no 2368 0.312207111873456 3433 5705015 SGTC_3034 9090421 49.47 µM -0.489910740052506 0.297117387326853 no 2369 0.312098531381613 3312 17173761 SGTC_1242 0402-0103 60.1 µM -0.493802929318886 0.295663300123079 no 2370 0.310722682088569 3269 432868 SGTC_2587 piperic acid 92.2 µM -0.494800747272708 0.29529105162974 no 2371 0.310370388414024 3257 5370536 SGTC_2515 chrysin 20.77 µM -0.495584613463503 0.294998771888401 no 2372 0.310093755368398 3323 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor. SGTC_2993 9054257 71.4286 µM -0.497139533148072 0.294419384635211 no 2373 0.309545329064988 3298 6470217 YGL055W OLE1 SGTC_2298 7976326 193.81 µM -0.497901800215456 0.294135544093011 no 2374 0.309276629198671 3287 2235818 SGTC_126 0417-1624 672.48 µM -0.498642283008352 0.293859936367834 no 2375 0.309015705940996 3432 41912 YDL195W SEC31 SGTC_646 4092-0839 27.3 µM -0.498714475442562 0.293833072732899 no 2376 0.308990272709265 3426 877796 SGTC_1268 0828-0275 2.46 µM -0.5005476519004 0.293151307712646 no 2377 0.308344755886034 3358 745337 SGTC_2835 9006588 71.43 µM -0.501212734401226 0.292904142568931 no 2378 0.308110706518986 3419 2345538 SGTC_1056 3448-1962 115 µM -0.502345914647888 0.292483240816029 no 2379 0.30771210846811 3355 715507 SGTC_3341 9147222 25.867 µM -0.503842277535302 0.291927871778265 no 2380 0.30718610791553 3386 1939759 SGTC_2047 4141938 200 µM -0.504869246060726 0.291547000972449 no 2381 0.306825337918061 3284 3807862 SGTC_2145 5634607 200 µM -0.505204438271969 0.291422738744615 no 2382 0.306707626680087 3262 308662 SGTC_2888 9058547 12.99 µM -0.505231210038458 0.291412814999238 no 2383 0.306698225955361 3272 16476514 SGTC_1359 1582-0056 520 nM -0.505351437026711 0.291368251261631 no 2384 0.306656010629367 3382 3661189 SGTC_1424 4048-1941 275 µM -0.505354028369591 0.29136729078082 no 2385 0.306655100758867 3404 X1424 SGTC_2950 9072895 21.46 µM -0.505758070815948 0.291217550591675 no 2386 0.306513248236962 3375 17332245 SGTC_2095 5432005 200 µM -0.506594611374227 0.290907638647979 no 2387 0.306219645034013 3272 783734 SGTC_1324 1418-0026 34.4 µM -0.506899406156055 0.290794760099539 no 2388 0.306112701187031 3356 1372513 SGTC_750 4073-0104 132 µM -0.507554305263071 0.29055229223632 no 2389 0.305882971555903 3314 22330957 SGTC_159 3970-0959 50 µM -0.507641074933915 0.290520173994836 no 2390 0.305852539670964 3452 6615653 SGTC_3184 9108758 49.47 µM -0.507865802548328 0.290436997633736 no 2391 0.305773729366614 3329 902885 SGTC_3167 9103034 49.47 µM -0.507982508007161 0.29039380691593 no 2392 0.305732805177568 3377 5127859 SGTC_582 0987-0078 156 µM -0.508180288155948 0.290320618692761 no 2393 0.305663456701904 3440 1625765 SGTC_338 4055-0136 114 µM -0.508879763974793 0.290061848123999 no 2394 0.305418252514289 3291 2900563 SGTC_723 4182-0001 115 µM -0.509354100237257 0.289886429307838 no 2395 0.305252021592094 3302 744821 YLR208W SEC13 SGTC_3331 9141060 1.957 µM -0.509829317605492 0.289710734552249 no 2396 0.305085522156161 3278 4906567 YPR165W RHO1 SGTC_833 3852-0053 558 µM -0.510312263763707 0.289532233566269 no 2397 0.304916356148335 3446 3123681 SGTC_1440 4100-1550 40 µM -0.510582425996364 0.289432401850604 no 2398 0.304821742110282 3345 742806 SGTC_509 pifithrin 175 µM -0.510739245739 0.2893744604436 no 2399 0.304766827950705 3413 4817 A p53 inhibitor. SGTC_795 0685-0265 78 µM -0.51106881385377 0.289252710119855 no 2400 0.304651436178463 3430 302754 SGTC_2059 5238311 157 µM -0.51132651609545 0.289157525541599 no 2401 0.304561220362512 3258 703021 SGTC_1304 1165-0502 251 µM -0.511718326205289 0.289012835273044 no 2402 0.304424079145349 3288 767425 SGTC_1835 st008666 49.2 µM -0.511894775600822 0.288947685980061 no 2403 0.304362327376682 3253 690455 SGTC_455 paf C-16 10 µM -0.512388978410776 0.288765251396151 no 2404 0.304189401544373 3323 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis. SGTC_1549 4'-methoxyflavonol 74.6 µM -0.514735251120096 0.287899867414388 no 2405 0.303369018349523 3372 97141 SGTC_1436 4092-1007 8.32 µM -0.515293257181818 0.287694236487897 no 2406 0.303174055028823 3301 2881121 SGTC_463 ikarugamyin 104 µM -0.517243377106789 0.286976143046085 no 2407 0.302493137624734 3375 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis. SGTC_1374 2889-5571 141 µM -0.518317645730546 0.28658092770307 no 2408 0.302118331661146 3329 2853281 SGTC_875 0709-0210 25.7 µM -0.518912685500341 0.286362128210779 no 2409 0.301910815576235 3431 6251364 SGTC_221 trifluoperazine 10.304 µM -0.519534266378554 0.286133654117256 no 2410 0.301694111876292 3398 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1 SGTC_197 4544-0043 41.561 µM -0.51995712297398 0.285978274493452 no 2411 0.301546730036078 3377 896523 SGTC_2930 9013230 14.89 µM -0.521536882037925 0.285398143466534 no 2412 0.300996409834275 3406 2995857 SGTC_3231 9132313 49.47 µM -0.521639415179225 0.285360509850085 no 2413 0.300960707343921 3356 4905967 SGTC_3063 1327-0034 4 µM -0.521752418732338 0.285319035926905 no 2414 0.300921361222131 3365 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_1670 st016595 4.04 µM -0.522089455835379 0.285195355536684 no 2415 0.300804023797738 3380 597879 SGTC_3270 9137563 49.47 µM -0.522627472833598 0.284997975777325 no 2416 0.300616759227649 3364 17015724 SGTC_421 streptovitacin 30 mM -0.522662993416896 0.284984946801081 no 2417 0.300604397628971 3444 91467 include heat shock SGTC_3036 9090181 49.47 µM -0.522786982688707 0.2849394696708 no 2418 0.300561249640299 3387 25236586 SGTC_83 0170-0301 39.027 µM -0.523228411738544 0.284777589199305 no 2419 0.300407656026989 3364 3089716 SGTC_1786 berberine 21.6 µM -0.523262860718291 0.284764957946259 no 2420 0.300395671123079 3368 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_1123 mangostin 811.285 nM -0.523636723134078 0.284627892688906 no 2421 0.300265617158334 3342 5281650 An antioxidant. SGTC_3099 9120367 49.47 µM -0.525728142607557 0.283861719041634 no 2422 0.299538553675494 3405 24824940 SGTC_167 3672-0051 66.205 µM -0.525951394640225 0.283779990920027 no 2423 0.299460989236732 3333 3237971 SGTC_2228 7354201 200 µM -0.526642044153902 0.283527229256836 no 2424 0.299221094600081 3369 753451 SGTC_807 1315-0151 48 µM -0.526793532777477 0.283471802373663 no 2425 0.299168487232292 3497 4011080 SGTC_1589 2',5'-dimethoxyflavone 47.2 µM -0.527025703033713 0.283386865654871 no 2426 0.299087869747567 3287 688667 SGTC_495 decylubiquinone 155 µM -0.528320418019923 0.282913433498043 no 2427 0.298638481211935 3378 2971 A Co-enzyme Q analog. A free radical scavenger. SGTC_1326 1431-2094 10.8 µM -0.531488288379819 0.281756657820425 no 2428 0.297540227475915 3306 616278 SGTC_3130 9127414 49.47 µM -0.531958888448573 0.281585008767169 no 2429 0.297377234827942 3402 1494646 SGTC_1084 voriconazole 435 nM -0.532184539221924 0.281502721653868 no 2430 0.297299095001819 3433 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_718 1130-0073 349 µM -0.532486561573488 0.281392602597919 no 2431 0.297194523410483 3497 6740020 SGTC_1731 st035964 63 µM -0.532818903944257 0.281271452720836 no 2432 0.297079473312118 3307 6739575 SGTC_737 1950-0117 57.9 µM -0.533144827294957 0.281152667253287 no 2433 0.296966665131205 3428 5393513 SGTC_622 1348-1566 26.3 µM -0.533308951818619 0.281092859883545 no 2434 0.296909865976796 3391 7340407 SGTC_2694 st077685 81.9 µM -0.533680808588942 0.280957377126543 no 2435 0.296781194582522 3297 2838096 SGTC_1352 1496-0991 99 µM -0.535038179415826 0.280463098982502 no 2436 0.296311728398913 3359 3000039 SGTC_2025 5147754 141 µM -0.535158837207872 0.280419182577621 no 2437 0.296270013655163 3378 315777 YLR208W SEC13 SGTC_3134 9127454 49.47 µM -0.537018687853146 0.279742665178684 no 2438 0.295627352732514 3477 24262820 SGTC_1672 st016598 6.51 µM -0.537491492133542 0.279570809787367 no 2439 0.295464080088904 3347 4665860 YNL267W PIK1 SGTC_2289 7946404 165.07 µM -0.537857055862428 0.279437969448034 no 2440 0.295337869067996 3352 1246120 YPR165W RHO1 SGTC_1366 1683-0113 21.9 µM -0.541278455923127 0.278196172686375 no 2441 0.29415783385303 3369 708623 SGTC_102 gallobenzophenone 83.616 µM -0.543204690253068 0.277498232149905 no 2442 0.293494438814619 3487 70837 SGTC_2709 st078560 56 µM -0.543233898953912 0.277487655429508 no 2443 0.293484384674471 3483 17250903 SGTC_1459 k035-0031 35.7 µM -0.543392074038166 0.277430382301426 no 2444 0.293429940845281 3358 3877128 YMR208W ERG12 SGTC_2648 atorvastatin 78.68 µM -0.543479024015746 0.277398901313989 no 2445 0.293400014675188 3457 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11 SGTC_1186 1319-0216 26 µM -0.543649066191578 0.277337341129165 no 2446 0.293341494180478 3479 4565136 SGTC_2265 7929201 200 µM -0.544861186304486 0.276898712233831 no 2447 0.292924496413313 3315 1265108 SGTC_1894 3',6'-dihydroxyflavone 78.7 µM -0.545966010109369 0.276499206719183 no 2448 0.29254465091633 3425 688662 SGTC_380 3970-0968 6 µM -0.547077840234353 0.276097453229783 no 2449 0.292162627838036 3346 2891601 SGTC_2951 9072950 58.06 µM -0.54725057078283 0.276035063758292 no 2450 0.29210329873339 3465 16488155 SGTC_1513 0337-0559 19 µM -0.548585837786514 0.275553005253855 no 2451 0.291644853522051 3325 775073 SGTC_1653 st012112 65 µM -0.551427272435492 0.274528569575408 no 2452 0.29067040471161 3469 720429 SGTC_927 2425-1185 123 µM -0.552584151790499 0.274112013419967 no 2453 0.29027409828258 3334 730375 SGTC_2094 5332512 191.667 µM -0.555022030826977 0.273235232877902 no 2454 0.28943979577454 3470 755774 SGTC_1329 1447-1697 50.6 µM -0.556177021351937 0.27282032737913 no 2455 0.289044923075874 3445 2840515 SGTC_613 3914-0030 117 µM -0.556441452379073 0.272725380206567 no 2456 0.288954554017734 3273 1145395 SGTC_1679 SEC14.276 6.7 µM -0.557045910187134 0.272508403882761 no 2457 0.28874803106362 3425 1005053 YMR079W SEC14 SGTC_2081 5214970 32.255 µM -0.55849332161549 0.271989189326995 no 2458 0.288253781809649 3434 2063512 SGTC_3154 9100113 49.47 µM -0.558561520278312 0.271964737286149 no 2459 0.288230503779944 3362 25237525 SGTC_1458 k015-0034 6.33 µM -0.558580225345041 0.271958030937283 no 2460 0.288224119394773 3412 3598957 SGTC_1764 st044502 93.5 µM -0.559104726503104 0.27177001443676 no 2461 0.288045124615699 3471 8407 SGTC_2032 5185112 25.99 µM -0.559174882456056 0.271744870729461 no 2462 0.28802118670391 3372 5718189 SGTC_2157 5649910 96.377 µM -0.559650863308433 0.271574311036801 no 2463 0.287858802085915 3399 2858091 SGTC_1512 0259-0544 12.2 µM -0.561334795617919 0.270971330597868 no 2464 0.287284662655158 3451 18476 SGTC_284 0988-0104 32.6 µM -0.56144078323898 0.270933401034396 no 2465 0.28724854413902 3437 4666532 SGTC_859 0439-0102 54.6 µM -0.562025578079763 0.270724169399604 no 2466 0.287049296103126 3498 610143 SGTC_302 1094-0063 18.9 µM -0.562356780963532 0.270605705311018 no 2467 0.286936479543667 3376 5440289 SGTC_603 3794-0023 45.9 µM -0.563875829350204 0.270062706566453 no 2468 0.286419320336697 3460 3802260 SGTC_1243 0416-0003 5.65 µM -0.564941104086521 0.269682239128903 no 2469 0.286056912213409 3384 2141977 SGTC_3290 9121031 71.43 µM -0.565983927887197 0.269310050380029 no 2470 0.285702353124991 3390 17014854 SGTC_191 3914-0123 66.505 µM -0.566781285658577 0.269025643497885 no 2471 0.28543139337229 3346 3144412 SGTC_1902 st060212 70.5 µM -0.567939548700773 0.268612775239017 no 2472 0.285038008169384 3509 688944 SGTC_704 1310-0270 142 µM -0.56830805200206 0.268481487321753 no 2473 0.284912906244138 3448 5718033 SGTC_2199 6590217 200 µM -0.568442171623435 0.268433712079541 no 2474 0.284867380934322 3398 703109 SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM -0.568650278399897 0.268359590064879 no 2475 0.284796748435846 3540 1377 SGTC_1650 st011916 45.8 µM -0.569653306766921 0.268002482874969 no 2476 0.284456432766308 3489 242528 SGTC_618 k072-0232 33.2 µM -0.569714389480554 0.267980743388747 no 2477 0.284435714400787 3430 5872756 YGL099W LSG1 SGTC_810 3825-7150 143 µM -0.569807540141469 0.267947592551779 no 2478 0.284404120443405 3516 22330411 YGL099W LSG1 SGTC_3236 9132701 49.47 µM -0.571001783808924 0.267522763288398 no 2479 0.283999216834032 3437 24282524 SGTC_2244 6635614 200 µM -0.571288623050194 0.267420776340397 no 2480 0.283902006213847 3283 836499 SGTC_1388 3346-4487 254 µM -0.571879948845012 0.267210589768692 no 2481 0.28370165452134 3463 3345614 SGTC_1545 lovastatin 49.4 µM -0.572901045707179 0.266847837607888 no 2482 0.283355848259808 3472 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12 SGTC_1978 st071761 42 µM -0.573432855723498 0.266659006784379 no 2483 0.283175824724228 3399 5147680 SGTC_1596 piperlongumine 63 µM -0.574112439018841 0.266417804170967 no 2484 0.282945858203146 3503 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_3083 9117465 49.47 µM -0.574998008721235 0.266103657095961 no 2485 0.282646321858373 3457 16420915 SGTC_828 2074-0507 139 µM -0.575078743145646 0.266075026692164 no 2486 0.282619021714926 3507 X828 SGTC_1005 4092-0690 4.4 µM -0.575982381952239 0.265754680730672 no 2487 0.282313545029326 3412 1529343 SGTC_3032 9089427 49.47 µM -0.576100440993747 0.265712842461338 no 2488 0.282273646699516 3464 17173707 SGTC_1188 1403-0014 4.57 µM -0.577997175886501 0.265041127546077 no 2489 0.281633012954795 3447 9614867 SGTC_2269 7935389 174.42 µM -0.579211233391089 0.264611631141769 no 2490 0.281223325996593 3451 97605 SGTC_2039 Aminomethylbenzodioxan 200 µM -0.57953334437986 0.264497737584749 no 2491 0.281114677104335 3442 15053 SGTC_1555 citronellol 128 µM -0.581082615379936 0.263950287617962 no 2492 0.280592387359067 3482 8842 A terpine precursor. SGTC_525 k781-2675 26.7 µM -0.582207226154568 0.263553257555203 no 2493 0.280213553288128 3525 3651118 YDL195W SEC31 SGTC_2445 5742597 35.57 µM -0.582220995116802 0.263548398480794 no 2494 0.28020891663973 3388 1774255 SGTC_2471 5466956 24.79 µM -0.583171895361739 0.263212935891502 no 2495 0.279888794365303 3404 724419 SGTC_2665 lovastatin 100 µM -0.583631359408729 0.263050922425377 no 2496 0.2797341785504 3494 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1 SGTC_1467 k284-1082 293 µM -0.585151953664607 0.262515103241011 no 2497 0.279222773931601 3486 3334705 SGTC_1957 st077035 62.4 µM -0.585922526753732 0.262243786108357 no 2498 0.278963789220281 3550 705593 SGTC_3280 9140961 49.47 µM -0.586806655268131 0.261932663416013 no 2499 0.278666783274229 3396 4901226 SGTC_3079 9117512 49.47 µM -0.586930469344783 0.261889108654176 no 2500 0.278625202613609 3515 7185044 SGTC_555 4296-0685 37 µM -0.58789767430149 0.261548997498507 no 2501 0.278300488800461 3463 2908540 YHR072W ERG7 SGTC_3224 9130643 49.47 µM -0.587991953073699 0.261515857130809 no 2502 0.27826884703405 3559 17644395 SGTC_3070 9117005 49.47 µM -0.589560176098059 0.260964920140423 no 2503 0.277742778657121 3528 8779016 SGTC_2464 5717415 7.67 µM -0.590847731516057 0.260513031891588 no 2504 0.277311225047497 3400 5285744 SGTC_1077 5-fluorocytosine 377 nM -0.591016350209191 0.260453882305511 no 2505 0.277254732934261 3491 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_1013 4112-3890 241 µM -0.591994114212412 0.26011102981377 no 2506 0.276927264863505 3387 705171 SGTC_2120 5538279 151.968 µM -0.592347293770672 0.25998724478941 no 2507 0.276809026220169 3510 2058197 SGTC_266 formosanin C 406 nM -0.592834681504183 0.259816471378213 no 2508 0.276645897530784 3458 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1 SGTC_3267 9137951 49.47 µM -0.593296036973056 0.259654872624253 no 2509 0.276491525259875 3465 16643986 SGTC_1410 3909-8106 77.9 µM -0.594046154425473 0.259392240153083 no 2510 0.27624062171945 3523 1039210 SGTC_78 0336-0123 156.75 µM -0.594764743352166 0.259140775268872 no 2511 0.276000368848157 3349 6765896 SGTC_906 1165-0455 526 µM -0.595845859907425 0.258762684099888 no 2512 0.275639102003262 3500 3252859 SGTC_1935 st074532 41.6 µM -0.595922012175717 0.258736062678698 no 2513 0.275613663662872 3560 2829742 SGTC_186 3455-3465 67.277 µM -0.596684797696279 0.258469485237221 no 2514 0.275358922121632 3481 755278 SGTC_883 0850-0245 24.6 µM -0.597137330901957 0.258311401697432 no 2515 0.275207847908297 3559 6823229 YPR165W RHO1 SGTC_1730 st033808 45.1 µM -0.598108409969929 0.257972343600445 no 2516 0.274883799540393 3446 1045166 SGTC_546 peri-Naphthalide 147 µM -0.598348776485494 0.257888453844614 no 2517 0.274803618454766 3421 223824 A penicillin ester. SGTC_95 0471-0001 561.058 µM -0.599239342360289 0.257577762949307 no 2518 0.274506645415483 3473 4015405 SGTC_787 4152-0075 138 µM -0.599697651148019 0.257417948978533 no 2519 0.274353876963728 3455 9566539 SGTC_1302 1159-0335 255 µM -0.60209869700183 0.256581538129791 no 2520 0.273554220912421 3508 649284 SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM -0.603710514378337 0.256020852233176 no 2521 0.273018061224055 3491 5379071 SGTC_2883 9059145 45.46 µM -0.604598129430649 0.255712360084415 no 2522 0.272723024931918 3490 16476510 SGTC_2701 st077767 14.721 µM -0.604699175835203 0.255677253540572 no 2523 0.272689447931127 3510 5721188 SGTC_2940 9060638 45.86 µM -0.604983373888302 0.255578528130297 no 2524 0.272595021941798 3499 4027022 SGTC_2853 9015042 58.44 µM -0.605268435502997 0.255479522740307 no 2525 0.272500325338341 3450 6457456 SGTC_1237 0330-0133 46.1 µM -0.606188972161746 0.255159945972615 no 2526 0.272194637441094 3483 X1237 YHR072W ERG7 SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM -0.606532083641504 0.255040883680398 no 2527 0.272080742058896 3504 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair. SGTC_1176 0848-0131 83.3 µM -0.607427836429629 0.254730187687673 no 2528 0.271783509880591 3533 6769040 SGTC_792 4534-1957 155 µM -0.607612783870587 0.254666062505876 no 2529 0.271722160033175 3458 1717904 SGTC_1757 st041620 31.8375 µM -0.60800594426205 0.254529773591344 no 2530 0.271591765724867 3518 5289815 SGTC_3008 9078912 71.4286 µM -0.608868630368351 0.254230857714075 no 2531 0.271305759269432 3523 16648731 SGTC_1305 1181-0477 144 µM -0.609191316700316 0.254119096037693 no 2532 0.271198817609374 3549 6252086 SGTC_513 4245-1575 41.7 µM -0.610987761631747 0.253497372815696 no 2533 0.270603841226381 3515 719745 SGTC_2600 tangeritin 87.95 µM -0.611253005383743 0.253405643609441 no 2534 0.270516048678107 3515 68077 A bioactive flavone. SGTC_175 3793-3120 23.7 µM -0.611839300896725 0.253202947036594 no 2535 0.270322042295229 3486 5322297 SGTC_1208 2323-2347 50.3 µM -0.612201516826283 0.253077762831242 no 2536 0.270202219074332 3542 5412760 SGTC_402 epigallocatechin gallate 10 µM -0.613869095656205 0.25250185688753 no 2537 0.269650916771814 3487 65064 An antioxidant. SGTC_518 1021-0119 62.6 µM -0.615700146169246 0.251870291558681 no 2538 0.269046220412377 3457 1097762 SGTC_1240 0356-0016 42.1 µM -0.616831399098087 0.251480517308461 no 2539 0.268672969542671 3490 4305613 SGTC_10 0279-0212 42.575 µM -0.61730397833757 0.251317784132275 no 2540 0.268517121627295 3546 39851 YBR002C RER2 SGTC_1333 1482-0047 286 µM -0.617738061694785 0.251168356124162 no 2541 0.268374008997695 3552 3811116 SGTC_1356 1502-0781 85.8 µM -0.617893238746505 0.251114949682658 no 2542 0.268322858096468 3518 567702 SGTC_3305 9127027 53.8275 µM -0.618239868375997 0.250995673748619 no 2543 0.268208616532221 3473 41905295 SGTC_1683 st010134 710 nM -0.618324136258659 0.250966681535846 no 2544 0.268180847374974 3547 3818134 SGTC_2912 7964298 10.93 µM -0.618741457398929 0.250823129076014 no 2545 0.268043347075115 3555 2975850 SGTC_2019 4016004 108 µM -0.619948940612135 0.25040801722626 no 2546 0.267645701666553 3500 45595336 SGTC_2403 6032726 181.2 µM -0.619965648951833 0.250402275743262 no 2547 0.267640201403489 3525 2881040 SGTC_3283 9109332 35.8195 µM -0.620014087445819 0.25038563122888 no 2548 0.267624256128023 3445 17027281 SGTC_1075 aripiprazole 15.2 µM -0.62032318320804 0.250279433051071 no 2549 0.267522517400191 3557 60795 An atypical antipschotic. YIL048W NEO1 SGTC_2534 helenine 20.12 µM -0.621041295343374 0.250032798503007 no 2550 0.26728622643081 3547 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58 SGTC_2132 5317594 122.667 µM -0.621277407609755 0.249951734274578 no 2551 0.267208557960125 3534 794577 SGTC_456 gingerol 170 µM -0.621333801724412 0.249932374593761 no 2552 0.267190008958952 3617 442793 A herb. SGTC_1826 st055655 41.6 µM -0.622334149471264 0.24958909494414 no 2553 0.266861085307952 3532 676168 SGTC_2660 2',4'-dihydroxychalcone 17.14 µM -0.623738748517712 0.249107515368582 no 2554 0.266399585622226 3562 5357218 A potent inhibitor of glutathione S-transferases. SGTC_505 gw-5074 63.9 µM -0.624051149059117 0.249000473231225 no 2555 0.266296997191875 3547 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases. SGTC_2892 9047358 58.44 µM -0.624273002765708 0.248924471278609 no 2556 0.266224155352824 3514 6466771 SGTC_2204 7233102 200 µM -0.625578561257192 0.24847746733561 no 2557 0.26579570215961 3498 2172480 SGTC_2880 9042983 58.44 µM -0.62568767078119 0.248440129223683 no 2558 0.26575991084506 3572 6464714 SGTC_1884 5633444 25 µM -0.626363283249708 0.248208996076659 no 2559 0.265538343375401 3589 5724239 SGTC_616 4092-0450 108 µM -0.627601345186202 0.24778574165261 no 2560 0.265132563636106 3567 787165 SGTC_1932 st074806 40.9 µM -0.627834144154428 0.247706198072852 no 2561 0.265056298037552 3662 17251235 SGTC_3221 9128209 49.47 µM -0.629135595623616 0.247261764818959 no 2562 0.264630144267531 3554 16460723 SGTC_741 4582-0002 126 µM -0.629209375823272 0.247236582361368 no 2563 0.26460599575328 3537 2912688 SGTC_2652 actinonin 100 µM -0.629457120993234 0.247152032686868 no 2564 0.264524916105791 3540 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase. SGTC_2925 9010536 32.5 µM -0.629787952795339 0.247039151591629 no 2565 0.264416664382095 3553 2994177 SGTC_606 k015-0008 38.6 µM -0.630405064309137 0.246828664480051 no 2566 0.264214799132165 3611 1970475 SGTC_1582 3',3',6'-trihydroxyflavone 74 µM -0.630408417568546 0.246827520997881 no 2567 0.26421370245158 3510 688803 SGTC_1960 st011366 51.8 µM -0.630886156897909 0.246664637921382 no 2568 0.264057481914476 3573 3972846 SGTC_196 k015-0023 18.111 µM -0.632359835092492 0.246162556837836 no 2569 0.263575886517773 3557 5211998 SGTC_1312 1218-2183 165 µM -0.632698346201346 0.246047303806167 no 2570 0.263465325026491 3588 6744073 SGTC_459 nigericin 15.3 µM -0.633364613969346 0.245820543900419 no 2571 0.263247783736377 3621 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification. SGTC_1290 0986-0249 10.2 µM -0.633658254154268 0.245720640998147 no 2572 0.263151937207655 3537 53329 SGTC_650 1328-0195 38 µM -0.633660084087542 0.245720018482628 no 2573 0.263151339958556 3555 2780821 SGTC_1017 4239-0030 168 µM -0.634587388921363 0.24540467242256 no 2574 0.262848777618412 3515 1149593 SGTC_160 3453-0671 289.699 µM -0.635053794689735 0.245246145310082 no 2575 0.262696665347546 3526 5322268 SGTC_764 1951-2361 146 µM -0.636609043741548 0.244717928312624 no 2576 0.262189766443375 3525 5438930 SGTC_529 4076-0302 30.3 µM -0.639446380131408 0.243755849808132 no 2577 0.261266292496941 3545 5816522 SGTC_791 1348-1292 225 µM -0.639617107809969 0.243698024993695 no 2578 0.261210778743247 3582 5437054 SGTC_2552 juarezic acid 87.02 µM -0.639681304010234 0.243676283901283 no 2579 0.261189906296819 3641 1549512 SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM -0.639701810651449 0.243669339212785 no 2580 0.261183239045907 3596 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_3249 9135183 49.47 µM -0.640445520539418 0.243417549940073 no 2581 0.260941498427214 3614 4902779 SGTC_2266 7929956 200 µM -0.640906226645439 0.243261644533728 no 2582 0.260791805057535 3585 2967153 SGTC_2807 7945238 51.95 µM -0.641592811181781 0.243029400853266 no 2583 0.260568800916451 3595 17148797 SGTC_3143 9086658 49.47 µM -0.6420801679704 0.242864620636722 no 2584 0.260410565974707 3614 25236626 SGTC_2812 7970281 58.44 µM -0.643710641074445 0.242313781063421 no 2585 0.259881544169438 3616 2233435 SGTC_3109 9122853 49.47 µM -0.645763829013399 0.241621095574002 no 2586 0.259216158205336 3606 1234709 SGTC_2792 7535235 81.82 µM -0.645982083989174 0.241547526002286 no 2587 0.259145479133133 3541 1281891 SGTC_2296 7971656 126.45 µM -0.646122612347923 0.241500163022706 no 2588 0.259099976101271 3582 666570 SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM -0.646698657790078 0.241306068253328 no 2589 0.258913495978256 3542 6857784 SGTC_1901 st060216 58.6 µM -0.647425623511436 0.241061242911312 no 2590 0.258678258376967 3599 688792 SGTC_2456 5770359 74.46 µM -0.647865822185413 0.240913059797025 no 2591 0.258535869038236 3598 3118787 SGTC_1029 k015-0030 64.7 µM -0.648225324157663 0.240792078202435 no 2592 0.258419612464114 3595 2208316 SGTC_375 3970-0961 9.27 µM -0.649215741004512 0.240458948698413 no 2593 0.258099469329851 3547 2898222 SGTC_2653 dihydrofissinolide 100 µM -0.649673330384779 0.240305122031656 no 2594 0.257951627262483 3610 6857746 SGTC_1663 st014140 55.4 µM -0.650381374717348 0.240067206257925 no 2595 0.257722952582167 3659 4207120 SGTC_781 4335-2806 94.4 µM -0.650908689571997 0.239890102342454 no 2596 0.257552715886097 3659 845254 SGTC_1908 st060353 56.5 µM -0.652198055987399 0.239457356184361 no 2597 0.257136706944609 3644 4227716 SGTC_2254 7938975 95.19 µM -0.653306227089216 0.239085764960326 no 2598 0.256779439360015 3651 2969277 SGTC_1619 st003326 88.7 µM -0.653540791276662 0.239007151485617 no 2599 0.256703850448814 3579 2849032 SGTC_1728 st035614 33.7865 µM -0.653745443664861 0.238938574404882 no 2600 0.256637910156159 3560 15945546 SGTC_2589 lobaric acid 100 µM -0.654830105086771 0.238575294308363 no 2601 0.256288572707503 3575 73157 A novel microtubule depolymerizer. SGTC_1608 st001473 40.5 µM -0.655121939359249 0.238477603386749 no 2602 0.256194623832529 3552 7292267 SGTC_6 0844-0013 19.835 µM -0.65516810950098 0.238462150033632 no 2603 0.256179762134941 3691 1584900 SGTC_3196 9111891 49.47 µM -0.656823585729053 0.237908417150774 no 2604 0.255647178405708 3610 18891510 SGTC_245 methotrexate 289.6 µM -0.656842340450368 0.237902148008847 no 2605 0.255641148133088 3589 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2 SGTC_2969 9091408 28.7 µM -0.659991277189675 0.236850838104697 no 2606 0.254629713513493 3547 4286311 SGTC_816 0325-0417 81.3 µM -0.661409875965116 0.236378057974815 no 2607 0.254174747063864 3604 68101 SGTC_2596 sinensetin 100 µM -0.662839686257371 0.235902067533095 no 2608 0.253716616664769 3588 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets. SGTC_194 1486-1323 56.904 µM -0.66358869075783 0.235652931506266 no 2609 0.25347679875744 3591 5178754 SGTC_1806 st050005 60.3 µM -0.664069951844059 0.235492929673239 no 2610 0.253322770403933 3586 5194765 SGTC_2458 5808907 16.39 µM -0.66425463333038 0.235431545705287 no 2611 0.253263675875641 3679 2731747 SGTC_643 k048-0106 28.4 µM -0.665172375473735 0.235126639886173 no 2612 0.252970123555177 3625 6763920 SGTC_2171 5739187 198.077 µM -0.666185627588859 0.23479025581542 no 2613 0.252646229157553 3565 2262761 SGTC_2816 7982706 58.44 µM -0.667646029607586 0.234305893261871 no 2614 0.252179784169568 3617 2981853 SGTC_412 gemfibrozil 100 µM -0.668477663778235 0.234030317608373 no 2615 0.251914367539395 3608 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels. SGTC_2721 ifenprodil 61.44 µM -0.669404732586685 0.233723329841391 no 2616 0.251618666756773 3630 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor. SGTC_2504 purpurogallin 52.29 µM -0.669806915275039 0.233590221302665 no 2617 0.251490442348644 3593 5281571 An antioxidant. SGTC_1602 st001878 87.6 µM -0.672234712015714 0.232787598104542 no 2618 0.250717142945662 3652 595405 YLR310C CDC25 SGTC_1311 1190-0148 100 µM -0.672987563041708 0.232539019178427 no 2619 0.250477601620341 3680 1961333 SGTC_2339 9000433 200 µM -0.676406078531653 0.231412140703934 no 2620 0.249391429508723 3609 2988954 SGTC_991 3996-0057 64.7 µM -0.676550078683891 0.231364739466289 no 2621 0.249345731051995 3631 715343 SGTC_1381 2324-0066 62.1 µM -0.677895757150159 0.23092203770909 no 2622 0.248918895170699 3639 10885928 SGTC_3145 9085516 49.47 µM -0.678371296779137 0.230765707692071 no 2623 0.248768151757408 3642 25236195 SGTC_2006 4011487 200 µM -0.678745797802465 0.230642634963276 no 2624 0.248649471240836 3670 45595294 SGTC_1430 4049-0248 69.1 µM -0.679860022234155 0.230276682986623 no 2625 0.248296548530502 3675 22774488 SGTC_64 000l-0018 272.079 µM -0.680273037804444 0.230141116133847 no 2626 0.248165796646366 3603 6811119 SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM -0.681067979084077 0.229880312975185 no 2627 0.247914238658263 3646 4330530 SGTC_150 3970-0969 77.2 µM -0.681762371391809 0.22965263322449 no 2628 0.247694610654933 3685 6615640 SGTC_569 4130-2812 160 µM -0.682867806098026 0.229290440203199 no 2629 0.247345189327745 3562 743552 SGTC_1881 5652484 16 µM -0.683058734228177 0.229227915511007 no 2630 0.247284864779241 3616 2255129 SGTC_2082 5219693 150 µM -0.683516740935685 0.229077967540077 no 2631 0.247140187699127 3654 2834649 SGTC_201 4262-0159 12.803 µM -0.683647111213065 0.229035295348477 no 2632 0.247099014067974 3620 1341029 SGTC_2090 5301565 104.445 µM -0.683793292043097 0.228987453424388 no 2633 0.247052851501211 3674 2056344 SGTC_559 1550-0661 158 µM -0.684113827102774 0.228882568642375 no 2634 0.246951645618002 3662 5830875 SGTC_2656 pseudo-anisatin 100 µM -0.687066188412182 0.22791777227855 no 2635 0.246020509923531 3679 6708809 A neurotoxin. SGTC_35 0133-0054 64.071 µM -0.687240180383466 0.22786098526604 no 2636 0.245965693992014 3604 99677 SGTC_220 paclitaxel 373.376 µM -0.688102784412033 0.227579568583205 no 2637 0.245694028589547 3616 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_371 0195-0006 7.36 µM -0.688301085834173 0.227514902233317 no 2638 0.245631599039524 3556 3928593 SGTC_2889 9059656 51.95 µM -0.688365701375665 0.227493833257306 no 2639 0.245611258518652 3713 3949838 SGTC_1746 st038117 42 µM -0.691010143283705 0.22663251211543 no 2640 0.244779583366802 3671 2898218 SGTC_1454 4239-0054 42.6 µM -0.691897876328545 0.226343781783752 no 2641 0.244500732196856 3749 1340767 SGTC_1255 0566-0045 221 µM -0.692514421085395 0.226143376282867 no 2642 0.244307166359244 3692 2788469 SGTC_1319 1306-0155 43.7 µM -0.69305772289543 0.225966861263616 no 2643 0.244136663822524 3701 3122360 SGTC_2115 tiliquinol 12.7705 µM -0.693520782891519 0.225816477764621 no 2644 0.243991393965606 3659 71208 A bioactive hydroxyquinoline. SGTC_526 4469-0568 170 µM -0.694061096125599 0.225641077059902 no 2645 0.243821947411666 3670 2901964 SGTC_507 nimesulide 162 µM -0.694963103905069 0.225348432082193 no 2646 0.243539212128298 3698 4495 A COX2 inhibitor. SGTC_2900 5328528 85.29 µM -0.695634165799021 0.225130854056831 no 2647 0.243328982009331 3687 795359 SGTC_3146 9095609 49.47 µM -0.69680237568546 0.224752370096873 no 2648 0.242963239579592 3708 17173999 SGTC_2728 chlorpromazine 9.18 µM -0.697773113604431 0.224438139024434 no 2649 0.24265954793164 3679 2726 A thorazine and dopamine antagonist. SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM -0.698026403302288 0.224356189346587 no 2650 0.24258034103978 3734 5393153 SGTC_2177 5811945 192 µM -0.698758406756069 0.224119451495474 no 2651 0.242351513020959 3698 5343475 SGTC_1423 4048-0112 5.59 µM -0.698782240114526 0.224111745914709 no 2652 0.24234406455798 3673 X1423 SGTC_1699 st031318 29.054 µM -0.699307052420506 0.22394210660201 no 2653 0.242180080299484 3729 5340658 SGTC_1091 telmisartan 47.6 µM -0.700771166348101 0.223469235159899 no 2654 0.241722917503588 3738 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension. SGTC_1945 st075991 56.6 µM -0.700944900195372 0.223413161285482 no 2655 0.241668701019887 3600 1084980 SGTC_2936 9038235 15.59 µM -0.701450794281245 0.223249925859011 no 2656 0.241510866114865 3675 4749415 SGTC_2302 7771753 200 µM -0.702308818772514 0.222973224770444 no 2657 0.241243297386044 3673 2203047 SGTC_2158 5657123 3.6195 µM -0.703135430993222 0.222706838545293 no 2658 0.240985676789578 3664 2858827 SGTC_888 0916-0002 6.97 µM -0.703323101746201 0.222646384551132 no 2659 0.240927208480688 3723 2802138 YIL048W NEO1 SGTC_3107 9121808 49.47 µM -0.704933055625317 0.222128157902351 no 2660 0.24042594892217 3623 662681 SGTC_772 k072-0172 35.3 µM -0.705831353863459 0.221839304962354 no 2661 0.240146510613077 3663 5861980 SGTC_3289 9119912 71.43 µM -0.705843447662587 0.221835417596235 no 2662 0.240142749740115 3688 17014829 SGTC_673 1082-0474 110 µM -0.709472206154275 0.220670767424213 no 2663 0.239015746658544 3714 3098046 SGTC_228 caffeine 993.056 µM -0.71125701328812 0.220099220931222 no 2664 0.238462492164559 3693 2519 Caffeine is a phosphodiesterase inhibitor. SGTC_207 4185-0010 4.486 µM -0.711476991875878 0.220028836295807 no 2665 0.238394351772029 3744 3761753 SGTC_1106 tegaserod maleate 11.7 µM -0.712809953979026 0.219602616291045 no 2666 0.237981682632349 3735 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation. SGTC_1966 st070145 16.1 µM -0.714030017939743 0.219212911880122 no 2667 0.237604308925498 3653 3748532 SGTC_1394 3474-0001 65.7 µM -0.716099389429111 0.218552837317307 no 2668 0.236964990386533 3675 5017666 YIL048W NEO1 SGTC_693 4161-2696 114 µM -0.717421068965657 0.218131856172214 no 2669 0.236557161618021 3720 805759 SGTC_2267 7931562 200 µM -0.718164662402052 0.217895212502735 no 2670 0.236327881934073 3629 934880 SGTC_2751 anetholtrithion 17.25 µM -0.719388070610839 0.217506193314764 no 2671 0.235950922507163 3696 2194 A chloretic substance that stimulates the liver to produce bile. SGTC_1476 4112-3294 3.34 µM -0.719700551701341 0.217406894931144 no 2672 0.235854693252504 3738 704369 SGTC_742 0kpi-0133 140 µM -0.721911097368355 0.216705188756267 no 2673 0.235174568988389 3718 2728852 SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM -0.722019687763091 0.216670752071213 no 2674 0.235141186635296 3769 6708561 SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM -0.72204260368558 0.216663485273022 no 2675 0.235134142263626 3703 6708760 SGTC_840 0245-0196 390 µM -0.72450826329532 0.215882431403312 no 2676 0.234376877981314 3790 3827528 SGTC_3020 9089140 49.47 µM -0.725014245493604 0.215722352016016 no 2677 0.234221645556111 3744 17217859 SGTC_1899 st063254 59.6 µM -0.726126467387216 0.215370716392263 no 2678 0.233880622437726 3659 3093813 SGTC_3159 9100096 49.47 µM -0.726369444151284 0.215293942114845 no 2679 0.233806158925499 3687 25236875 SGTC_1718 roemerine 11.9335 µM -0.72685276698791 0.215141272014447 no 2680 0.233658077182031 3627 235224 An aporphine alkaloid with mutagenic activity. SGTC_914 3820-6779 408 µM -0.727146828617245 0.215048415752267 no 2681 0.233568007241905 3695 2893481 SGTC_1956 st077085 54 µM -0.728375818973133 0.214660587652758 no 2682 0.233191780714907 3758 24208685 SGTC_2810 7959871 45.46 µM -0.728483014701132 0.214626779564164 no 2683 0.23315898121869 3733 2974535 SGTC_1293 1000-1278 195 µM -0.729138081581944 0.214420247546278 no 2684 0.232958601053262 3764 678847 SGTC_2916 7875993 68.79 µM -0.72984647294912 0.214197033296729 no 2685 0.232742017005131 3687 1299250 SGTC_2959 9079155 11 µM -0.730074054621857 0.214125350973937 no 2686 0.2326724597904 3708 16189457 SGTC_2128 5255449 168.493 µM -0.731148069494233 0.213787252593363 no 2687 0.232344357866074 3727 736008 SGTC_1166 k206-0078 225 µM -0.732020840477925 0.213512734629709 no 2688 0.232077923819344 3747 5404595 SGTC_2435 5706476 10.6 µM -0.733075717149941 0.213181212201422 no 2689 0.231756124829515 3729 5725375 SGTC_1168 k815-0004 80.5 µM -0.733417250026527 0.213073940981771 no 2690 0.231651990655 3708 642433 SGTC_2666 tannic acid 100 µM -0.73383781287728 0.212941890703908 no 2691 0.231523795888477 3737 16134267 A thiamine antagonist. SGTC_1449 4112-4002 201 µM -0.734157081394904 0.212841677186898 no 2692 0.231426503784422 3732 2059539 SGTC_1995 st072814 61.1 µM -0.735184419187296 0.212519398388848 no 2693 0.231113593362226 3704 5769371 SGTC_1669 st015249 58.4 µM -0.736000075246344 0.212263727874971 no 2694 0.230865325998043 3800 722793 SGTC_774 k060-0086 136 µM -0.736049764073687 0.212248158533564 no 2695 0.230850206650295 3746 5911235 SGTC_1968 st069590 43.6 µM -0.737384793991791 0.211830094400848 no 2696 0.230444189971565 3709 6384066 SGTC_1527 coumarin 137 µM -0.739272224504346 0.211239869037654 no 2697 0.229870855898483 3791 323 A hepatotoxic, DNA x-linker. SGTC_3250 9135583 49.47 µM -0.741562476006522 0.210524971564178 no 2698 0.229176232824694 3769 7699353 SGTC_729 4092-0585 94.1 µM -0.74173983607524 0.210469668270828 no 2699 0.229122489460618 3734 2169061 SGTC_49 0717-0965 32.132 µM -0.741937979455842 0.210407894542505 no 2700 0.229062456731632 3807 5889349 YGL099W LSG1 SGTC_2516 gossypol 71.55 µM -0.743878593048896 0.209803446304476 no 2701 0.228474963619028 3774 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_3113 9123498 49.47 µM -0.744255587022462 0.209686141484356 no 2702 0.22836093234447 3770 8897275 SGTC_1770 st043884 66.3 µM -0.744957843317051 0.20946773144354 no 2703 0.228148602633513 3732 670149 SGTC_3169 9102970 49.47 µM -0.746430757288616 0.209010072719205 no 2704 0.227703622586442 3809 17027839 SGTC_2597 laccaic acid a 100 µM -0.747603096411555 0.208646228840896 no 2705 0.227349798245019 3760 5491415 A textile dye. SGTC_1396 3511-0007 98.6 µM -0.74881509485613 0.208270469202092 no 2706 0.226984330181546 3724 X1396 SGTC_2780 5215298 71.43 µM -0.749946482755101 0.20792006206526 no 2707 0.226643468746002 3742 2834131 SGTC_3170 9103054 49.47 µM -0.750355391100952 0.207793502949153 no 2708 0.226520345077244 3740 16432970 SGTC_949 1165-0505 146 µM -0.751198209381109 0.207532790187783 no 2709 0.226266688847659 3795 6244267 SGTC_379 3970-0972 5.9 µM -0.751463993192342 0.207450614199605 no 2710 0.226186731327771 3764 2898042 YBL034C STU1 SGTC_3248 9135562 49.47 µM -0.751835799332052 0.207335690127673 no 2711 0.226074905196061 3783 17650701 SGTC_2813 7971799 71.43 µM -0.751903435596053 0.207314788025286 no 2712 0.226054565960745 3821 2234054 SGTC_480 am 92016 50 µM -0.752483316593958 0.207135634529929 no 2713 0.225880229532226 3682 2129 K+ channel blocker. SGTC_2005 4024620 188 µM -0.754306877979682 0.206572844705751 no 2714 0.225332486644459 3752 236743 SGTC_1928 4'-methoxychalcone 40.3 µM -0.754435413316185 0.206533210166033 no 2715 0.225293906898889 3811 641818 SGTC_3281 9140613 49.47 µM -0.756582597299268 0.20587178120798 no 2716 0.224649985322368 3737 16013766 SGTC_1745 st081495 74 µM -0.757522989657467 0.205582494349719 no 2717 0.224368298984306 3690 13842402 YBL026W LSM2 SGTC_524 r073-0010 27.8 µM -0.7575806479608 0.205564765151517 no 2718 0.224351034467318 3719 2772106 SGTC_1777 st045864 34.765 µM -0.758259819716625 0.205355996762999 no 2719 0.224147728114662 3758 4691462 SGTC_1062 mesoridazine 14.2 µM -0.758661018931754 0.20523273263592 no 2720 0.224027680499165 3772 4078 A neuroleptic. SGTC_45 0kpi-0036 14.9 µM -0.760830079870529 0.204567073742069 no 2721 0.223379282736206 3753 2795021 SGTC_2639 lactacystin 53 µM -0.761001914524977 0.204514394714956 no 2722 0.223327961861078 3788 3870 A proteasome inhibitor. SGTC_1469 k284-2957 126 µM -0.762484981418244 0.204060069300818 no 2723 0.222885301703981 3768 23884841 SGTC_2446 5162541 200 µM -0.763980878997937 0.203602422940576 no 2724 0.222439318688947 3748 1549321 SGTC_1108 betulinic acid 729.144 nM -0.766790162652044 0.20274462262783 no 2725 0.221603143091923 3794 64945 Apoptosis-inducing agent of unknown mechanism. SGTC_2004 4023728 41.89 µM -0.766849658203675 0.20272647934907 no 2726 0.221585453850484 3777 360084 YDR527W RBA50 SGTC_808 0711-0032 135 µM -0.7692522834211 0.201994605293793 no 2727 0.220871778990538 3744 4252555 SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM -0.770011407779342 0.201763694317093 no 2728 0.220646562869991 3901 16725076 SGTC_867 0518-0118 155 µM -0.77105096105736 0.201447738858502 no 2729 0.220338362952581 3807 6848158 SGTC_1306 1185-0270 9.02 µM -0.771973361281597 0.201167638602852 no 2730 0.220065102560678 3812 1548076 SGTC_2966 9084041 48.03 µM -0.772104051770604 0.201127971431009 no 2731 0.220026401328736 3747 17741380 SGTC_776 4476-4378 112 µM -0.772643190913668 0.200964381537075 no 2732 0.219866787928251 3853 2892008 SGTC_121 0557-0495 61.343 µM -0.772670593120541 0.200956069073432 no 2733 0.219858677216039 3916 3104427 SGTC_1267 0828-0272 9.49 µM -0.772881354749455 0.200892141396112 no 2734 0.219796300136852 3826 745334 SGTC_2960 9079389 5.97 µM -0.77398205475926 0.200558478209326 no 2735 0.219470701719146 3763 16457355 SGTC_2448 5185112 27.17 µM -0.774258617576377 0.200474694055136 no 2736 0.2193889351639 3792 5718189 SGTC_902 1120-0002 2.07 µM -0.775404685526719 0.200127719169106 no 2737 0.219050283652113 3774 3280475 SGTC_1647 st011722 22.4 µM -0.776845378970052 0.199692058142962 no 2738 0.218625000054837 3765 2854783 SGTC_2943 9068529 45.32 µM -0.777413861731659 0.199520307918791 no 2739 0.218457318407029 3804 3270634 SGTC_1165 k072-0275 30.3 µM -0.778504198885996 0.199191143749013 no 2740 0.218135916121604 3792 6153523 YGL055W OLE1 SGTC_1181 1222-0449 220 µM -0.778856784093767 0.199084771090072 no 2741 0.218032041757849 3810 658318 SGTC_899 1083-0020 478 µM -0.778917973903302 0.199066314009107 no 2742 0.218014017664956 3851 767123 SGTC_148 3253-0744 288.01 µM -0.784853779757496 0.197280762718859 no 2743 0.216269652071393 3761 6893655 SGTC_1914 st062367 72.6 µM -0.787574425562086 0.196465612752065 no 2744 0.215472839406628 3830 978205 SGTC_1431 4049-0260 9.09 µM -0.788401567010768 0.196218192829133 no 2745 0.215230927259088 3785 3854841 SGTC_1648 st011736 69.8 µM -0.788863482338991 0.196080103967025 no 2746 0.215095900572682 3816 2855514 SGTC_2675 theaflavin digallate 100 µM -0.790414957612974 0.195616724508528 no 2747 0.214642734834242 3784 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative. SGTC_1516 st013856 110 µM -0.792003773338041 0.195142882277967 no 2748 0.214179238030927 3874 5281404 A mutagen and neurotoxin. SGTC_594 1487-1584 10.8 µM -0.792795539123482 0.194907009795504 no 2749 0.213948477970303 3795 5013332 SGTC_424 splitomicin 100 mM -0.7930386747636 0.194834612821587 no 2750 0.213877645170035 3913 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_11 0438-0307 1.3 µM -0.796136417783172 0.193913649630732 no 2751 0.21297637442882 3820 4011476 SGTC_486 niguldipine 82 µM -0.796292570179398 0.193867295659207 no 2752 0.21293100152315 3849 1236 A calcium channel blocker. SGTC_120 rhodamine 6G 52.259 µM -0.796488512562606 0.193809139551477 no 2753 0.212874074897357 3866 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase SGTC_2837 9008476 45.46 µM -0.799188724423306 0.193008794503519 no 2754 0.212090494521927 3807 2992805 SGTC_2202 7226349 200 µM -0.80005040544655 0.192753816923191 no 2755 0.211840796845729 3791 844334 SGTC_2072 5231554 129 µM -0.802570927582074 0.1920091586831 no 2756 0.211111388780544 3878 789545 SGTC_1896 st058441 89 µM -0.80277017415893 0.191950368837839 no 2757 0.211053792119562 3865 688759 SGTC_74 000s-0487 160.283 µM -0.80307254749564 0.191861171382619 no 2758 0.210966401969414 3761 677548 SGTC_945 3381-0768 11.3 µM -0.805365324786257 0.19118564837849 no 2759 0.210304447687383 3880 1126236 YIL048W NEO1 SGTC_2562 3',7'-dimethoxyflavone 64.92 µM -0.807337588579818 0.190605726782794 no 2760 0.209736006776002 3900 688664 SGTC_185 k048-0037 25.491 µM -0.809729148949252 0.189903966167009 no 2761 0.209047930576971 3862 6827589 SGTC_190 3970-0790 3.722 µM -0.810015336237876 0.189820096170854 no 2762 0.208965680741213 3759 2832352 SGTC_3295 9122362 53.5725 µM -0.810205673152878 0.189764328681813 no 2763 0.208910988727889 3894 4730473 SGTC_2615 purpurogallin-4-carboxylic acid 100 µM -0.811593150867595 0.189358111156581 no 2764 0.208512561329201 3838 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase. SGTC_1817 st052116 64.4 µM -0.811764095435488 0.189308100077261 no 2765 0.208463503994387 3827 4361398 SGTC_2568 diosmetin 100 µM -0.812700457388488 0.189034304836863 no 2766 0.20819490946343 3875 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.  SGTC_3210 9128157 49.47 µM -0.812868528809993 0.188985186045909 no 2767 0.208146719962834 3929 17590849 SGTC_416 estradiol valerate 100 µM -0.81343391165714 0.188820010902264 no 2768 0.207984661505798 3893 13791 A steroid. SGTC_2007 4011539 71.82 µM -0.814140304742047 0.188613765037202 no 2769 0.207782289302788 3846 45595301 SGTC_1250 0485-0349 40.2 µM -0.814446128613199 0.188524516619959 no 2770 0.207694710928738 3866 6842794 YDL195W SEC31 SGTC_2697 mebhydrolin 72.4 µM -0.815977078304987 0.188078131973508 no 2771 0.207256622846902 3898 22530 H1 Histamine receptor antagonist. YIL048W NEO1 SGTC_761 k216-0224 480 µM -0.816459680095498 0.187937553337929 no 2772 0.207118637554097 3860 1340404 SGTC_403 arphamenine a 50 µM -0.817331879845929 0.187683652080556 no 2773 0.206869396487303 3831 5487158 An arginine aminopeptidase inhibitor. SGTC_1936 st074407 74.3 µM -0.817846073229326 0.187534067414683 no 2774 0.206722543056082 3898 809813 SGTC_1131 3454-3128 32.3 µM -0.817922099530908 0.187511956757786 no 2775 0.206700835212922 3932 710982 SGTC_3205 9113483 49.47 µM -0.819111441429641 0.187166271347898 no 2776 0.20636141734317 3930 17018033 SGTC_3022 9087993 49.47 µM -0.819184033970735 0.187145184901044 no 2777 0.206340711371701 3887 17173644 SGTC_3325 9138760 55.175 µM -0.8201959699524 0.186851394019924 no 2778 0.206052199512431 3827 43844959 SGTC_1524 corynanthine 62.1 µM -0.820909148058349 0.18664451174795 no 2779 0.205849009940325 3989 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist. SGTC_2775 cyproheptadine 69.59 µM -0.821752451146599 0.186400065243697 no 2780 0.205608900278167 3857 2913 A selective serotonin reuptake inhibitor. SGTC_2759 disulfiram 3.38 µM -0.822171810010737 0.186278580431544 no 2781 0.205489560151513 3796 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_2884 9058502 51.95 µM -0.82503240891286 0.185451197778274 no 2782 0.204676595663845 3872 6471554 SGTC_291 SEC14.278 35.5 µM -0.826956770476327 0.184895892338587 no 2783 0.204130782119779 3864 1068044 SGTC_2373 9071805 200 µM -0.829543945093793 0.184150951986894 no 2784 0.20339834043273 3823 10149009 SGTC_907 3448-6986 75.5 µM -0.829675291046946 0.184113182672233 no 2785 0.20336119762642 3888 590582 SGTC_832 4083-0019 164 µM -0.829837501195554 0.184066544828955 no 2786 0.203315332441251 3945 1990758 SGTC_1133 3473-0247 50 µM -0.829940692549837 0.184036879599526 no 2787 0.203286158129623 3889 711311 SGTC_1687 st020778 55.3625 µM -0.82999482608849 0.184021318596229 no 2788 0.203270854467444 3876 4259299 SGTC_260 nsc-65238 3.989 µM -0.830683930315732 0.183823303136274 no 2789 0.203076103383231 3841 3246252 SGTC_1626 st003712 1.76 µM -0.830877105397551 0.183767817720992 no 2790 0.203021529236405 3857 24207035 SGTC_2706 st078239 82.5 µM -0.833084972554177 0.183134396296784 no 2791 0.20239840406195 3857 15434492 SGTC_1965 Pectolinarigenin 58.4 µM -0.833794546856479 0.182931113991493 no 2792 0.20219838438232 3856 5320438 An anti-inflammatory. SGTC_895 0964-0006 13.7 µM -0.834992524648484 0.182588231176516 no 2793 0.201860958660255 3844 6738897 SGTC_1233 0325-0408 14.2 µM -0.835182268611659 0.182533959880935 no 2794 0.201807545797769 3941 12874 SGTC_2300 7976697 71.57 µM -0.835490472033927 0.182445827833223 no 2795 0.201720804676363 3791 2236109 SGTC_2264 7948757 110.76 µM -0.835757652987458 0.182369447845006 no 2796 0.201645627037109 3838 2971411 SGTC_1439 4092-1168 46 µM -0.836206481502805 0.182241184586905 no 2797 0.201519376370911 3888 2886240 SGTC_1880 MG-132 525 µM -0.837446580839352 0.18188709033538 no 2798 0.20117079597619 3817 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1 SGTC_2224 6650123 117.647 µM -0.838243989408314 0.181659628143279 no 2799 0.200946842960378 3842 2908370 SGTC_1840 st055363 71 µM -0.839059341305216 0.18142723171838 no 2800 0.20071800527699 3923 676033 SGTC_1367 1812-0510 76.9 µM -0.839226358878015 0.181379650358664 no 2801 0.200671149226879 3936 1142582 YDR527W RBA50 SGTC_1039 k821-0043 94 µM -0.8400431821373 0.181147059490883 no 2802 0.200442087635078 3870 15992768 SGTC_1437 4092-1038 11.6 µM -0.845013812896126 0.179735700500568 no 2803 0.199051563462214 3907 3977136 SGTC_944 3370-0224 231 µM -0.84571505370916 0.17953714798794 no 2804 0.198855861616772 3937 4580514 SGTC_2225 6654152 15.4 µM -0.848387719053222 0.178781662061058 no 2805 0.198111039912361 3786 97582 YGR029W | YLR033W ERV1 | RSC58 SGTC_2350 9023895 38.85 µM -0.854621369902687 0.177027378642355 no 2806 0.196380396594681 3943 2997209 SGTC_860 0443-0016 25.1 µM -0.856417167043292 0.176524027442589 no 2807 0.19588353618877 3936 5337942 SGTC_1692 fluoroquinolonic acid 71 µM -0.856989829531942 0.176363704116352 no 2808 0.195725252718794 3962 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2 SGTC_1377 2944-0135 198 µM -0.859728152967485 0.175598353634245 no 2809 0.19496945601258 3968 1894137 SGTC_1360 1598-0022 39.8 µM -0.859817733217644 0.175573351915857 no 2810 0.194944761240039 3984 761525 SGTC_442 cape 100 µM -0.860721267979941 0.175321302809298 no 2811 0.194695788295134 3853 5281787 SGTC_580 1123-0028 41 µM -0.860794583941521 0.175300860734161 no 2812 0.194675594251218 3980 1677248 YPR107C YTH1 SGTC_2971 9092186 9.93 µM -0.861638288887409 0.175065726332859 no 2813 0.19444329708817 3951 25236400 SGTC_1951 sophoraflavanone G 9.2 µM -0.866269583854087 0.173778584221465 no 2814 0.19317117103616 3900 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity. SGTC_3311 9131146 2.8755 µM -0.866578901715759 0.173692832735906 no 2815 0.193086388853695 3907 4900406 YPR165W RHO1 SGTC_1597 7-benzyloxygramine 47.5 µM -0.866622972045175 0.173680617410271 no 2816 0.193074311288342 3894 260807 SGTC_70 0141-0289 43.283 µM -0.866702365355014 0.173658612710907 no 2817 0.193052554550796 3944 352408 SGTC_962 1254-0300 21.5 µM -0.867389565869065 0.173468221914407 no 2818 0.192864298458796 3895 7340576 SGTC_2617 dihydrotanshinone i 20.83 µM -0.867604507324645 0.17340869907796 no 2819 0.192805439055593 3925 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12 SGTC_959 1222-0044 107 µM -0.868340063117965 0.173205103083943 no 2820 0.192604098070874 3896 6083612 SGTC_345 1362-0200 395 µM -0.868689236457067 0.173108507985415 no 2821 0.192508565132769 3930 1419823 SGTC_979 1426-2828 121 µM -0.869519650172473 0.172878920712691 no 2822 0.192281482443292 4034 747872 SGTC_1105 epirubicin 18.1 µM -0.870637835813003 0.172570078872189 no 2823 0.191975965379743 3944 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_1937 st074714 47.2 µM -0.8711320972816 0.172433676505461 no 2824 0.191841015180258 3881 17250970 SGTC_1856 st057054 55.7 µM -0.872806733733312 0.171972034979607 no 2825 0.191384214345864 3949 1266018 SGTC_223 busulfan 5 mM -0.87308147406505 0.17189637362873 no 2826 0.191309335444123 3950 2478 A DNA alkylator. SGTC_3003 9075612 71.4286 µM -0.873185690819748 0.171867678706424 no 2827 0.191280936463518 3962 6501993 SGTC_2098 5376439 882.5 nM -0.87485115840614 0.171409525841864 no 2828 0.190827448588889 3958 2844116 SGTC_3346 9158254 43.5805 µM -0.87512292289918 0.171334840397175 no 2829 0.190753512861851 3953 17639500 SGTC_504 lovastatin 124 µM -0.875901296676955 0.171121045353485 no 2830 0.190541847281784 3961 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1 SGTC_2427 5545055 42.75 µM -0.876471937022436 0.170964416655008 no 2831 0.190386762939411 3906 5372858 SGTC_1775 st081588 35.1725 µM -0.878172021772638 0.170498323232229 no 2832 0.189925186398268 3960 1426443 YGL099W LSG1 SGTC_3256 9138902 49.47 µM -0.878795834965126 0.17032750352652 no 2833 0.189755992495744 3995 17228773 SGTC_2020 4017018 200 µM -0.878822423244807 0.170320225254592 no 2834 0.189748783142611 4037 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope. SGTC_2211 7117706 200 µM -0.879039712004822 0.170260752127271 no 2835 0.189689872090453 3864 822771 SGTC_771 0250-0039 27.3 µM -0.879117581536317 0.170239442047453 no 2836 0.189668762940656 3896 3005115 SGTC_2057 5236571 38.335 µM -0.879237130257047 0.170206729203853 no 2837 0.189636358060024 3942 54684039 YBR257W POP4 SGTC_1071 trifluoperazine 6.31 µM -0.881191244492967 0.169672584096851 no 2838 0.189107158703326 4054 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. SGTC_195 4234-0266 16.654 µM -0.881601727640691 0.169560517851366 no 2839 0.188996110268336 3939 2303354 SGTC_142 0335-0849 62.6745 µM -0.881691312341732 0.169536066593774 no 2840 0.188971880166645 3948 3889043 YPR107C YTH1 SGTC_3108 9121785 49.47 µM -0.882242073187371 0.169385791582753 no 2841 0.188822957148097 3809 17140271 SGTC_2286 7945697 125 µM -0.883683839915612 0.168992810709501 no 2842 0.188433453126007 3972 1245733 SGTC_363 0455-0021 3.06 µM -0.884934268402735 0.168652457290832 no 2843 0.188096042129252 3948 4597466 SGTC_3156 9099931 49.47 µM -0.885691555104074 0.168446546221653 no 2844 0.187891880107863 3968 18111053 SGTC_2558 carylophyllene oxide 100 µM -0.886182265812359 0.168313205210992 no 2845 0.187759659192448 4051 6708694 An oxygenated terpenoid and antifungal agent. SGTC_1609 st001574 46.4 µM -0.887608290582979 0.167926096383109 no 2846 0.187375746254422 3934 3960012 SGTC_3192 9110362 49.47 µM -0.887674900629914 0.167908028434073 no 2847 0.187357825435833 3974 16649480 SGTC_2406 ethylparaben 405.7 µM -0.888493253983123 0.167686152545136 no 2848 0.187137741497341 4002 8434 A possible steroid mimic. SGTC_100 0086-0128 49.5915 µM -0.889816814959003 0.167327702180381 no 2849 0.186782128090078 4019 93297 SGTC_856 0433-0016 11.3 µM -0.891210791529679 0.166950716005686 no 2850 0.186408048038162 4013 3911780 SGTC_1408 3909-7976 48.8 µM -0.89129206747001 0.166928752703624 no 2851 0.186386251591762 4009 24152374 SGTC_2528 xanthyletin 44.79 µM -0.891858976829389 0.166775607894826 no 2852 0.186234262699774 4000 65188 An natural product with antifungal activity of unknown mechanism. SGTC_2307 7538926 6.34 µM -0.89208520278383 0.166714520561963 no 2853 0.186173632770105 3984 96582 SGTC_1369 1866-0067 208 µM -0.892604709532943 0.166574293869638 no 2854 0.186034448114915 3926 3531355 SGTC_806 3966-4455 5.86 µM -0.892873983256122 0.166501640729932 no 2855 0.185962330515167 3946 714982 SGTC_2677 mitomycin C 100 µM -0.893124997474049 0.166433932639727 no 2856 0.185895118837717 3975 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_609 0986-0026 86.3 µM -0.895048541666574 0.165915669712307 no 2857 0.185380569956958 3922 2848610 SGTC_1373 2887-0003 58.5 µM -0.895528753737361 0.165786448444694 no 2858 0.185252251078484 3953 776948 SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM -0.896602394052702 0.165497775745157 no 2859 0.184965560067782 3966 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_2440 5628896 157.78 µM -0.897520450367433 0.165251193387372 no 2860 0.184720632972474 3967 5522048 SGTC_3286 9117135 37.221 µM -0.898029561876101 0.165114552772911 no 2861 0.184584894701902 3938 3438150 SGTC_3163 9099914 49.47 µM -0.898181567272529 0.165073770174388 no 2862 0.184544379361122 3960 16268368 SGTC_1175 0741-0056 27.6 µM -0.898801334683874 0.164907555916629 no 2863 0.184379244532293 4065 765927 SGTC_2696 st077691 74.316 µM -0.899057677458786 0.164838839526263 no 2864 0.184310969792842 4020 757133 SGTC_1445 4239-0156 97.7 µM -0.900188365648244 0.164535963545928 no 2865 0.184010008274741 4074 4008346 SGTC_3352 9151559 45.5865 µM -0.901058582396543 0.164303105480334 no 2866 0.183778586373618 3967 17159339 SGTC_3135 9127742 49.47 µM -0.901593005580074 0.16416020712619 no 2867 0.183636553948881 4052 3643468 SGTC_2974 9094440 9.66 µM -0.903532437870509 0.163642303446244 no 2868 0.18312169021057 4028 25236134 SGTC_1612 st002233 45.4 µM -0.904972595665404 0.163258412520188 no 2869 0.182739952744646 3968 1035021 SGTC_2383 9036125 200 µM -0.906875501028055 0.162752068929457 no 2870 0.182236318960848 3875 79580 SGTC_2241 6772625 37.8075 µM -0.907660243502888 0.162543554789006 no 2871 0.182028877419267 3862 2285411 SGTC_570 0987-0065 62.6 µM -0.907786436429319 0.162510040262095 no 2872 0.181995532929519 3774 3104428 SGTC_3122 9126309 49.47 µM -0.907914765379633 0.162475963058163 no 2873 0.181961627946288 4012 17591206 SGTC_2461 5755302 26.15 µM -0.911242752663868 0.161593854423074 no 2874 0.181083741187694 4040 2788904 SGTC_1592 4',5'-dihydroxyflavone 8.85 µM -0.91124496833467 0.161593268184375 no 2875 0.181083157603191 3988 688669 SGTC_3347 9188721 44.724 µM -0.91587198403749 0.160372042605364 no 2876 0.179867021288462 4014 44118411 YKL104C | YBL026W GFA1 | LSM2 SGTC_2867 9039098 71.43 µM -0.916381327907877 0.160237979023138 no 2877 0.179733462624874 3956 6463460 SGTC_1704 st028805 70.8 µM -0.917565195087687 0.159926658331878 no 2878 0.179423273216304 4025 2876101 SGTC_1824 st053723 68.6 µM -0.919241379484019 0.159486550372059 no 2879 0.178984665931051 4027 675225 SGTC_409 arachidonic acid 100 µM -0.924824015680182 0.158026466532883 no 2880 0.17752872813567 3994 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes. SGTC_2815 7968870 71.43 µM -0.928793914918795 0.156993533991255 no 2881 0.176497949309129 4003 2977326 YHR190W ERG9 SGTC_2821 7996764 71.43 µM -0.928923524155375 0.156959885856011 no 2882 0.176464360388898 4049 2987135 SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM -0.929681826700391 0.15676311637178 no 2883 0.176267923309351 4047 6708784 An antioxidant flavonoid SGTC_344 k064-0035 6.43 µM -0.930305501825125 0.156601402641917 no 2884 0.176106465001087 3967 5088750 SGTC_2388 9080168 200 µM -0.931745538372327 0.156228432916406 no 2885 0.175734023132559 3983 15943073 SGTC_2382 9035899 200 µM -0.932367835818645 0.156067438999772 no 2886 0.175573230615711 3997 6462679 SGTC_1905 st060207 84.5 µM -0.933068341113319 0.155886342865263 no 2887 0.175392341925293 3960 1948547 SGTC_3041 9091929 49.47 µM -0.935317422502103 0.155305842269301 no 2888 0.174812369586922 4018 25236887 SGTC_1364 1653-0028 37.6 µM -0.935472569086756 0.155265850730933 no 2889 0.17477240675001 4005 5718652 SGTC_2896 9052656 71.43 µM -0.935479170823724 0.155264149177365 no 2890 0.174770706395599 3889 6469436 SGTC_15 0266-0086 27.098 µM -0.937599334358376 0.154718327875874 no 2891 0.174225176797951 4076 1712902 YIL048W NEO1 SGTC_2790 5423970 71.43 µM -0.937979211785215 0.154620665177672 no 2892 0.174127546707914 4101 1376240 YKL165C | YIL048W MCD4 | NEO1 SGTC_1708 st033234 31.827 µM -0.938304375242954 0.154537101263532 no 2893 0.174044005964604 4112 674664 SGTC_2322 7413319 38.22 µM -0.938342190786231 0.154527384966777 no 2894 0.174034292078772 4072 1840400 SGTC_1887 st057648 70.8 µM -0.93891910732097 0.15437920254554 no 2895 0.173886139108976 4033 688672 SGTC_2371 9071574 200 µM -0.941185684461311 0.153797936584707 no 2896 0.173304855781299 4032 45596039 SGTC_3239 9133757 49.47 µM -0.943326562385113 0.153250238384329 no 2897 0.172756946672701 4024 17036923 SGTC_1277 0873-0036 22 µM -0.945063129957455 0.152806924893911 no 2898 0.172313323592348 4082 5965735 SGTC_1867 st057372 64 µM -0.947501971018301 0.152185771295324 no 2899 0.171691526178428 3997 688837 SGTC_978 1416-0512 87.4 µM -0.948176147584494 0.152014360032133 no 2900 0.171519893935037 4109 6814003 SGTC_54 0159-0055 9 µM -0.950374343644511 0.151456353597934 no 2901 0.170961037826575 4023 3319099 SGTC_2805 7950783 58.44 µM -0.951163104494495 0.15125646112311 no 2902 0.170760792339217 4051 1178958 YDL195W SEC31 SGTC_753 1322-0200 289 µM -0.952377341163284 0.150949085185308 no 2903 0.17045282335273 4121 5403907 SGTC_298 1391-0729 10 µM -0.953525181855701 0.150658899464363 no 2904 0.170162021764881 3985 3237558 SGTC_475 α-linolenic acid 10 µM -0.953958074430201 0.150549556384204 no 2905 0.170052432489119 4044 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_755 1995-0008 37.3 µM -0.954136596555965 0.150504479395832 no 2906 0.170007251750698 3996 689533 SGTC_581 0958-0271 211 µM -0.954539219120085 0.150402849863013 no 2907 0.169905383471058 4036 4591145 SGTC_1825 st052143 62.6 µM -0.954966965625305 0.150294928676492 no 2908 0.169797201419018 4075 674173 SGTC_2335 9018011 154.17 µM -0.958521715375093 0.149400055886437 no 2909 0.168899873380399 4051 6458208 SGTC_2131 toluylene red 5.2905 µM -0.959965232240084 0.149037682423432 no 2910 0.168536356722883 4036 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain. SGTC_2771 fluoxetine 41.05 µM -0.960319464574763 0.148948847453112 no 2911 0.168447228341991 4039 3386 A selective serotonin reuptake inhibitor. SGTC_2755 lomerizine 42.69 µM -0.962232249068359 0.148469767570659 no 2912 0.167966476542178 4017 3949 A calcium channel blocker. SGTC_2237 6667747 47.222 µM -0.962562332990985 0.148387198453419 no 2913 0.167883603972188 4043 729940 YDL015C TSC13 SGTC_1259 0671-0132 43 µM -0.965791301334084 0.147581105344633 no 2914 0.167074311046146 3964 X1259 SGTC_1081 sertraline 6 µM -0.966003409199221 0.147528256721209 no 2915 0.167021237556017 4042 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1 SGTC_1344 1488-0097 29.1 µM -0.966955060493833 0.14729130012281 no 2916 0.166783249832821 4075 747966 SGTC_1576 erythromycin ethylsuccinate 23.2 µM -0.966990380995776 0.147282510399829 no 2917 0.16677442114029 4042 3256 An antibiotic and ribosome inhibitor. SGTC_1474 0330-0125 5.35 µM -0.96712622912357 0.147248707038674 no 2918 0.166740467429882 4051 X1474 SGTC_1289 0976-0073 69.1 µM -0.967694519777688 0.147107354522547 no 2919 0.166598477938222 4099 3391136 SGTC_1493 4348-0038 111 µM -0.967805876670397 0.147079667076419 no 2920 0.166570664159461 4030 800424 SGTC_227 fluconazole 33.516 µM -0.96878480327619 0.146836420055048 no 2921 0.166326285182952 4052 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C SGTC_2227 7312221 64.1025 µM -0.969931456468498 0.146551839126915 no 2922 0.166040329574877 4117 887188 YOR168W | YOR169C GLN4 | YOR169C SGTC_2397 5161689 200 µM -0.972509489878291 0.14591336514403 no 2923 0.165398573047879 4117 2259942 SGTC_2904 7225135 42.03 µM -0.973422989230085 0.14568757770807 no 2924 0.165171558868554 4161 4446116 SGTC_2498 4'-Methoxychalcone 54.63 µM -0.973895314631641 0.145570926344709 no 2925 0.165054260182693 4036 641818 YHR062C RPP1 SGTC_711 k292-0785 179 µM -0.975313600749625 0.145221026275307 no 2926 0.164702363013274 4013 4146315 SGTC_141 0443-0274 32.331 µM -0.975667018394645 0.145133924080006 no 2927 0.164614750723488 4070 1627241 SGTC_3030 9087619 49.47 µM -0.978843849627021 0.144352550866015 no 2928 0.16382856986376 4097 25236973 SGTC_2733 amorolfine 100 µM -0.981529792339197 0.143694132462264 no 2929 0.163165775089263 4154 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_335 4077-0256 27.6 µM -0.982063281071433 0.143563597355351 no 2930 0.163034336834386 4055 3121989 SGTC_1615 st002656 86.5 µM -0.982262309708221 0.143514919130935 no 2931 0.162985318798669 4062 1584458 SGTC_1878 temozolomide 1 mM -0.982374671580333 0.143487442698136 no 2932 0.162957649835492 3969 5394 DNA alkylating agent. SGTC_669 0108-0021 26.2 µM -0.982600568065001 0.143432213803424 no 2933 0.162902032365129 3978 17201 SGTC_2251 lansoprazole 556 µM -0.983144793127126 0.143299216457773 no 2934 0.162768090616771 3996 3883 Gastric proton pump inhibitor. YBR192W RIM2 SGTC_447 ml7 120 µM -0.983190369833336 0.143288082234249 no 2935 0.162756876773993 4083 4216 Selective myosin light chain kinase inhibitor. SGTC_2187 6125751 200 µM -0.985058812620502 0.142832131357702 no 2936 0.162297591519974 4090 874498 SGTC_1747 st037496 66.6 µM -0.985235207479621 0.142789136930169 no 2937 0.162254275213767 4059 723305 SGTC_3195 9113082 49.47 µM -0.986580944400206 0.142461415411455 no 2938 0.161924057843325 4037 17018038 SGTC_1053 3366-3204 134 µM -0.987655738245673 0.142200041193156 no 2939 0.161660639268524 4098 3632071 YPR165W RHO1 SGTC_1636 st007707 68.9 µM -0.989183477760304 0.141829075974282 no 2940 0.161286690320948 4115 403051 SGTC_1339 1486-1321 22.7 µM -0.991303551984851 0.141315366874 no 2941 0.160768689549046 4084 3469382 SGTC_1385 3091-4834 14.1 µM -0.991790936353009 0.141197448692413 no 2942 0.160649759967445 4058 4072814 SGTC_854 0422-0053 192 µM -0.993039332917287 0.140895714933284 no 2943 0.16034539338922 4097 3596728 SGTC_2864 9034755 47.6 µM -0.993895687241561 0.140688989740941 no 2944 0.160136827117579 4023 4930451 SGTC_2961 9083290 32.55 µM -0.995414822913861 0.140322774834798 no 2945 0.159767276122094 4019 17741490 SGTC_2467 5474540 200 µM -0.995740578539602 0.140244329966033 no 2946 0.159688104219264 4038 5413519 SGTC_2336 9001819 198.65 µM -0.995818767411142 0.140225505819744 no 2947 0.159669104955712 4157 2989602 SGTC_2857 9024691 58.44 µM -0.996760795903019 0.139998845241795 no 2948 0.159440315923487 4186 16478292 SGTC_1701 st028638 40.4 µM -0.997176721000191 0.139898849169931 no 2949 0.159339369158024 4094 3490878 SGTC_2203 7227154 166.4 µM -0.999035093608063 0.139452655159844 no 2950 0.158888845672927 4068 896304 SGTC_348 k064-0012 10.7 µM -1.00087603365572 0.139011602099146 no 2951 0.158443372281465 3993 5066323 SGTC_1022 4477-0945 21.3 µM -1.00282927489347 0.138544683220003 no 2952 0.157971620697525 4048 4648966 SGTC_1911 st060208 74.3 µM -1.00304132750094 0.13849405679608 no 2953 0.157920460785864 4136 688783 SGTC_3220 9131269 49.47 µM -1.00466919425563 0.138105832185182 no 2954 0.157528083252178 4108 17722206 SGTC_510 ag-490 170 µM -1.0078904710729 0.137339789398518 no 2955 0.156753523343356 4203 5328779 SGTC_130 0136-0219 337.655 µM -1.00885213746552 0.137111661718928 no 2956 0.156522776145632 3937 234244 SGTC_1179 1021-1431 9.29 µM -1.00945190105886 0.136969516212169 no 2957 0.156378979066286 4133 2840958 SGTC_2797 7859098 81.82 µM -1.00990083486369 0.136863183673828 no 2958 0.156271401328134 4091 972681 SGTC_1111 tnp00062 510.699 nM -1.0107889427652 0.136652996488052 no 2959 0.156058728212901 4147 676306 SGTC_788 1182-0090 188 µM -1.01176103409094 0.136423186201321 no 2960 0.155826162534439 4145 5715185 SGTC_765 1319-0117 244 µM -1.01183796822153 0.136405009643975 no 2961 0.155807766374196 4065 3487746 YGL099W LSG1 SGTC_350 k064-0020 19.8 µM -1.01566566728815 0.13550276373173 no 2962 0.154894311253687 4132 2790705 SGTC_2512 diallyl trisulfide 49.23 µM -1.01666476916702 0.135267935017159 no 2963 0.154656465505407 4132 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent SGTC_1642 st009582 77.7 µM -1.01736903700913 0.135102571771473 no 2964 0.154488952914461 4101 6739311 SGTC_748 act1.228 77.9 µM -1.02081464693795 0.134295535456646 no 2965 0.153671131813251 4055 4421505 YNR035C ARC35 SGTC_2091 4-phenylthiadiazole 200 µM -1.02090082980917 0.1342753920959 no 2966 0.153650712980401 4097 270010 SGTC_2273 7815444 169.05 µM -1.02129813022118 0.134182558648642 no 2967 0.153556606012387 4080 2824616 SGTC_2342 7990637 118.86 µM -1.02625978451909 0.133026928305234 no 2968 0.15238457394467 4175 2033102 YER133W GLC7 SGTC_336 4111-0029 111 µM -1.0264464437727 0.132983587195735 no 2969 0.152340597862861 4114 3131175 SGTC_2668 2',4'-dihydroxychalcone 15.08 µM -1.02899963247496 0.132391728564774 no 2970 0.151739923784247 4153 5357218 A potent inhibitor of glutathione S-transferases. SGTC_1114 scopoletin 1.73284 µM -1.02926054555761 0.13233134829455 no 2971 0.151678629019708 4154 5280460 A coumarin with genotoxic properties. SGTC_2124 5246320 200 µM -1.03014067815878 0.132127808816198 no 2972 0.1514719860804 4135 579342 SGTC_192 3455-0609 60.9 µM -1.03079838555344 0.131975848389201 no 2973 0.151317687758565 4188 3769639 SGTC_1790 st045711 43.5 µM -1.04196591353763 0.12941402950022 no 2974 0.148713741328612 4132 585119 SGTC_1571 st070080 73.4 µM -1.0427019653121 0.129246398832405 no 2975 0.148543173692618 4179 4315245 SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM -1.04421154044197 0.128903074627807 no 2976 0.148193764398722 4066 1241132 A phosphatase inhibitor. SGTC_168 3970-0862 530.542 µM -1.04442390983054 0.12885482604239 no 2977 0.148144653112575 4102 3135186 SGTC_1033 k072-0102 21.3 µM -1.04546501218613 0.128618477356305 no 2978 0.147904051526489 4108 5965931 SGTC_2855 9016525 58.44 µM -1.04923122499632 0.127765993680305 no 2979 0.147035855349715 4100 43811474 SGTC_2136 5328288 199.296 µM -1.04976533227639 0.127645416987756 no 2980 0.146913008940767 4130 262395 SGTC_299 1273-0059 1.44 µM -1.05426423586835 0.126632912065023 no 2981 0.145880978952831 4001 2848077 SGTC_2153 5569715 200 µM -1.05664210415245 0.126100024138121 no 2982 0.145337478530857 4177 2054701 SGTC_3061 glucosamine 200 µM -1.05909927765466 0.125551008110721 no 2983 0.144777284457692 4072 91431 and experimental redox chemotherapeutic SGTC_3339 9145883 14.936 µM -1.05964225500744 0.125429913887862 no 2984 0.144653691215402 4049 2030670 SGTC_2340 7987427 183.45 µM -1.05981117926836 0.125392257213102 no 2985 0.144615254944686 4179 2239331 SGTC_415 dibenzyl ketone 100 µM -1.06335080979113 0.124605015796071 no 2986 0.143811445640113 4139 7593 SGTC_724 3910-0327 137 µM -1.06487492152307 0.124267107797313 no 2987 0.143466267568785 4217 2885483 SGTC_1026 k007-1105 30.6 µM -1.0652747516364 0.124178568426117 no 2988 0.143375807456604 4148 7066794 SGTC_39 0986-0283 58.349 µM -1.06660995818281 0.123883216773651 no 2989 0.143074000921398 4249 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2 SGTC_815 1582-0027 36.9 µM -1.07943710254772 0.121070852763787 no 2990 0.140196459273274 4203 3128206 SGTC_13 0199-0087 65 µM -1.07956199171214 0.121043693293718 no 2991 0.140168637233892 4244 4589825 SGTC_1055 3448-0672 86 µM -1.08088217746629 0.120756856484097 no 2992 0.139874763754822 4178 748378 SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM -1.08170894438532 0.120577468623304 no 2993 0.13969093875029 4227 23847180 SGTC_1416 3966-0321 25.3 µM -1.08194344138947 0.120526622779792 no 2994 0.139638830133545 4216 582530 YLR208W SEC13 SGTC_912 3474-0017 2.18 µM -1.08345585838643 0.120199049027139 no 2995 0.139303066806612 4218 3360550 SGTC_2903 5923464 63.88 µM -1.08450418187893 0.119972361503081 no 2996 0.139070656905904 4178 2876576 SGTC_797 k781-0471 270 µM -1.08622945918045 0.119599947134927 no 2997 0.138688743463499 4148 23738129 SGTC_1810 st050138 53 µM -1.08633589774976 0.119576998285863 no 2998 0.138665205267982 4184 3444541 SGTC_1057 3448-5381 134 µM -1.086532522731 0.119534612827988 no 2999 0.138621730092942 4165 5497911 SGTC_2152 5568786 200 µM -1.08786896198433 0.119246804166418 no 3000 0.13832647998055 4185 5399883 SGTC_3074 9116018 49.47 µM -1.0879886216635 0.119221058752265 no 3001 0.138300065334111 4239 17027303 SGTC_2061 5245884 80.95 µM -1.08877704846483 0.119051522634545 no 3002 0.138126107585958 4155 573863 SGTC_2051 5263410 176 µM -1.0927751705546 0.118194423150488 no 3003 0.137246262912048 4178 227584 SGTC_2483 5729050 27.16 µM -1.09347704482065 0.118044409866766 no 3004 0.137092201175781 4215 2865180 SGTC_499 genistein 192 µM -1.0982591302088 0.117025907345512 no 3005 0.136045676386243 4278 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger. SGTC_2344 7990960 76.95 µM -1.09958012829775 0.116745658238553 no 3006 0.135757552034464 4168 140813 SGTC_1067 clotrimazole 1.36 µM -1.10048552479442 0.116553853829313 no 3007 0.135560316557421 4229 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_2044 5102272 200 µM -1.1022405033396 0.116182705741729 no 3008 0.135178563802509 4190 592666 SGTC_1325 1431-0015 227 µM -1.105515556155 0.115492332543086 no 3009 0.134468128782273 4205 1103340 SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM -1.10593580932126 0.11540395565393 no 3010 0.134377152018368 4243 279621 SGTC_2517 totarol 10 µM -1.10636368484351 0.115314025212975 no 3011 0.134284568591103 4216 460178 An antibacterial membrane disruptor. YGL001C ERG26 SGTC_408 cantharidin 100 µM -1.10667496882449 0.115248631171783 no 3012 0.13421724070035 4164 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_1816 st051957 91.6 µM -1.11102258165067 0.114338045909029 no 3013 0.133279314711955 4195 674121 SGTC_1235 benzylparaben 21.5 µM -1.11473960596992 0.113563605834078 no 3014 0.132481011769456 4230 7180 SGTC_1295 1013-0063 9.78 µM -1.11527743988901 0.113451858887851 no 3015 0.132365774953685 4222 6826038 SGTC_2872 9044037 25.97 µM -1.11666490995115 0.113163943293956 no 3016 0.132068813328177 4221 6465195 SGTC_2674 ligustilide 100 µM -1.11766817276635 0.112956080040401 no 3017 0.131854370381662 4262 5319022 A signalling regulator. SGTC_759 3486-0358 89.3 µM -1.12264700196304 0.111928562080872 no 3018 0.130793722445421 4207 875103 SGTC_2575 plumbagin 510 nM -1.12573399017872 0.111294843757747 no 3019 0.130139065963547 4129 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM -1.13185154565894 0.110046587186102 no 3020 0.128848426345717 4224 521171 SGTC_2215 7188065 200 µM -1.1341802442169 0.109574077272783 no 3021 0.128359474576328 4261 940217 SGTC_1819 st053448 58.6 µM -1.13450795508926 0.109507699456174 no 3022 0.128290769373235 4115 2857616 SGTC_2249 haloperidol 116.36 µM -1.136212775834 0.109162853959502 no 3023 0.127933762451142 4192 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_2731 amoxapine 43.43 µM -1.13696344194923 0.109011259400245 no 3024 0.127776784371574 4364 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine. SGTC_743 1275-0778 158 µM -1.13862396656086 0.108676459607833 no 3025 0.127430013896336 4211 2849257 YMR203W TOM40 SGTC_2442 5158906 48.48 µM -1.13912478500004 0.10857562844497 no 3026 0.12732555562372 4237 1893835 SGTC_1151 3909-8316 15.3 µM -1.13994676777264 0.108410282271025 no 3027 0.127154239586897 4271 800431 SGTC_116 0155-0182 31.788 µM -1.14349006096046 0.107699603969082 no 3028 0.126417589492386 4126 771486 SGTC_483 fpl-64176 144 µM -1.14408035244563 0.10758153610824 no 3029 0.12629515751008 4341 3423 SGTC_1544 7-methoxy-4-methylcoumarin 105 µM -1.14411402879282 0.107574803106562 no 3030 0.126288175212678 4232 390807 SGTC_460 trequinsin 123 µM -1.14580765857803 0.107236582734507 no 3031 0.125937372798022 4309 5537 A vasodilator. SGTC_2484 5809818 12.04 µM -1.1469978492144 0.106999359071554 no 3032 0.125691254915062 4203 2870548 SGTC_2401 5128683 200 µM -1.14878837729712 0.106643192196776 no 3033 0.125321626549637 4258 708373 SGTC_3338 9144300 39.5675 µM -1.14954380076779 0.10649318240836 no 3034 0.125165908249794 4229 4901274 SGTC_2569 tetrandrine 100 µM -1.15021610617464 0.106359806136471 no 3035 0.125027437067912 4249 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM -1.15283371011772 0.105841658222903 no 3036 0.124489322544873 4240 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding. SGTC_955 1216-0110 33 µM -1.15584867871772 0.105247116896508 no 3037 0.123871528901883 4224 3619719 SGTC_165 k038-0023 64.381 µM -1.15594121504022 0.105228907354384 no 3038 0.123852601397058 4243 46368543 SGTC_448 monastrol 171 µM -1.15627268858166 0.105163697823514 no 3039 0.123784817963784 4164 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity SGTC_229 benomyl 22.8748 µM -1.15931723644771 0.104566122900789 no 3040 0.123163449220168 4264 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C SGTC_1384 3089-0840 101 µM -1.16115267898739 0.104207058206014 no 3041 0.122789907449439 4234 1069836 SGTC_1489 4065-0444 182 µM -1.16227532749233 0.103987877254289 no 3042 0.122561822605619 4242 2877968 SGTC_311 1315-0136 58 µM -1.16333949463117 0.103780422761349 no 3043 0.122345893813171 4266 6759207 SGTC_3088 9117578 49.47 µM -1.16438823686781 0.103576269175237 no 3044 0.122133356239648 4305 678341 SGTC_1338 1486-1223 76 µM -1.16760165726158 0.102952543022287 no 3045 0.121483740703357 4265 3444526 SGTC_2206 7254556 146.969 µM -1.16766980321028 0.102939345477925 no 3046 0.121469990871751 4271 4398905 SGTC_274 sirtinol 40.1 µM -1.17115613439534 0.102265801094581 no 3047 0.120768011840892 4309 6836442 NAD-dependent acetyltransferase inhibitor. SGTC_343 4130-2827 29.8 µM -1.17584310345093 0.101365357976511 no 3048 0.119828789223927 4258 1118244 SGTC_1667 st014849 34.6 µM -1.17586768800719 0.101360650158959 no 3049 0.119823876335896 4335 5348460 SGTC_2313 7726885 200 µM -1.17658992245965 0.101222417000004 no 3050 0.119679611004021 4277 726423 SGTC_1465 k213-0056 144 µM -1.177162381845 0.101112947898114 no 3051 0.11956535009333 4156 24048857 YMR208W ERG12 SGTC_2079 5212404 121 µM -1.17916624867757 0.100730436176811 no 3052 0.119165991411899 4232 758462 SGTC_963 1269-2853 151 µM -1.18258896527394 0.100079527387777 no 3053 0.118486043945977 4244 3668223 SGTC_1987 st072290 61.9 µM -1.18749746110001 0.09915143123942 no 3054 0.117515728724872 4288 54697379 SGTC_1129 3453-1384 223 µM -1.18761430348591 0.0991294156922724 no 3055 0.11749269998771 4338 1084452 SGTC_1762 st045503 25.4615 µM -1.18851563373661 0.0989597063875129 no 3056 0.117315162102437 4346 4645554 SGTC_1860 st056228 74.6 µM -1.18956483156792 0.0987624232828177 no 3057 0.117108737684751 4257 688679 SGTC_756 0508-1999 28.3 µM -1.19108033393448 0.0984779682085432 no 3058 0.116811024713315 4292 6753853 SGTC_2727 riluzole 51.77 µM -1.19407564654293 0.0979175226807017 no 3059 0.116224189311277 4326 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.  SGTC_727 3032-0951 202 µM -1.19628924732374 0.0975048459413024 no 3060 0.115791851698209 4323 3652836 SGTC_3005 9076496 71.4286 µM -1.20405129263689 0.0960678642615892 no 3061 0.114284877038176 4248 21368410 SGTC_1238 0333-0287 48.8 µM -1.20876124368982 0.0952035396729727 no 3062 0.113377292569163 4273 7226 SGTC_1621 st003705 32.4 µM -1.20997824536451 0.0949811411386959 no 3063 0.113143620346643 4300 24207032 SGTC_534 k292-0788 63.4 µM -1.21055575740736 0.0948757388538312 no 3064 0.113032854591046 4346 4146317 SGTC_77 0828-0286 12.516 µM -1.2109473577604 0.0948043165399248 no 3065 0.112957790400994 4196 745345 SGTC_3115 9123671 49.47 µM -1.21102325069175 0.0947904793371421 no 3066 0.112943246927841 4418 3286988 SGTC_2062 5245942 200 µM -1.21250761492958 0.0945201412999046 no 3067 0.112659064718504 4339 1376160 SGTC_2150 5556613 200 µM -1.21297139227248 0.0944357930672033 no 3068 0.112570379121991 4314 743190 SGTC_1034 k072-0165 12.7 µM -1.21395040044429 0.0942579209051543 no 3069 0.112383332518606 4324 5835461 SGTC_1407 3909-7909 12.3 µM -1.21499312304884 0.0940687446065362 no 3070 0.112184357134583 4311 4411780 SGTC_374 0880-0231 82.3 µM -1.21751381050245 0.0936125854556574 no 3071 0.111704392564759 4172 6833587 SGTC_1677 st019204 53.9 µM -1.21845666736742 0.0934423806759015 no 3072 0.111525241041251 4324 3945625 SGTC_3227 9130768 49.47 µM -1.21862713608513 0.0934116320314123 no 3073 0.11149287236767 4360 17720899 SGTC_2911 7942208 15.64 µM -1.23107518223432 0.0911864413334661 no 3074 0.109147373325613 4341 1243384 SGTC_812 4251-0442 148 µM -1.23137339983461 0.091133618832897 no 3075 0.10909162049047 4335 5723007 SGTC_1893 st059353 36.1 µM -1.23181859852751 0.0910548041875477 no 3076 0.10900842710843 4332 3112488 SGTC_18 0111-0177 500 nM -1.23413098184821 0.0906462502514944 no 3077 0.108577050211728 4390 721752 SGTC_2658 polymyxin b sulfate 77.05 µM -1.23415649678074 0.0906417498524955 no 3078 0.108572297240462 4334 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides.  YIL048W NEO1 SGTC_3082 9117008 49.47 µM -1.23569806477633 0.0903701511558907 no 3079 0.108285408584905 4347 41448529 SGTC_1883 5-benzylidenerhodanine 20 µM -1.23621996267695 0.0902783384752011 no 3080 0.108188406147406 4293 1273210 SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM -1.23715139689418 0.0901146520342128 no 3081 0.108015440791783 4294 442882 SGTC_91 0417-1751 58.384 µM -1.23875034597999 0.0898341735556931 no 3082 0.107718983782323 4412 6795624 SGTC_563 tetrahydrosecaminediol 614 µM -1.24584538815044 0.0885974266356357 no 3083 0.10641058136348 4372 334274 A psychoactive constituent of the cannabis plant. SGTC_557 1315-0110 16.2 µM -1.24816395308485 0.0881960363149634 no 3084 0.105985510889053 4313 6833801 SGTC_1480 1070-0044 41.2 µM -1.2486626047846 0.0881098870457464 no 3085 0.10589425190248 4358 3124987 SGTC_3291 9121177 71.43 µM -1.25126090746832 0.087662007689781 no 3086 0.105419651531347 4312 17015612 SGTC_2180 6301957 200 µM -1.25178408723801 0.0875720310003449 no 3087 0.105324275020991 4351 845462 SGTC_1428 4049-0204 61.7 µM -1.25194336272683 0.0875446524193114 no 3088 0.105295251243385 4359 X1428 SGTC_2163 5671233 125 µM -1.25208249114447 0.0875207422362717 no 3089 0.105269903475933 4304 701023 SGTC_86 0417-1630 471.922 µM -1.25456591554992 0.0870947680469385 no 3090 0.10481819160201 4334 3634867 SGTC_705 1124-0212 310 µM -1.25677701245985 0.0867168100526975 no 3091 0.104417196111262 4321 9554485 SGTC_2506 ethyl hematommate 54.16 µM -1.25850999849561 0.0864214367088733 no 3092 0.104103686763205 4382 3940691 An allergen. SGTC_392 N-ethylmaleimide 8.33 µM -1.26255250815664 0.085735348959 no 3093 0.10337502231988 4294 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides. SGTC_2627 acetyl isogambogic acid 100 µM -1.26483196688364 0.0853502852800156 no 3094 0.102965784745538 4348 6857789 A caspase activator and apoptosis inducer. SGTC_2208 7283366 200 µM -1.26485746869667 0.0853459846579369 no 3095 0.102961213000697 4323 898663 SGTC_2018 5133068 143 µM -1.268484301374 0.0847360079655177 no 3096 0.102312526702353 4298 785362 SGTC_2362 9071156 126 µM -1.27125183586833 0.0842727553408353 no 3097 0.101819535496916 4356 653133 SGTC_2787 5284540 71.43 µM -1.27414151635965 0.083791088043198 no 3098 0.101306633654732 4369 736958 SGTC_1046 2001-0062 216 µM -1.2770551475377 0.083307525136096 no 3099 0.100791389154272 4278 739778 SGTC_1711 st032263 62.8 µM -1.27765415857695 0.0832083703426967 no 3100 0.100685697699144 4336 3958979 SGTC_3263 9137018 49.47 µM -1.27837093902667 0.0830898377320669 no 3101 0.100559332890566 4307 43844957 SGTC_1578 josamycin 24.2 µM -1.28382029576184 0.0821928373039999 no 3102 0.0996024202332076 4360 5282165 A P450 substrate. SGTC_427 1354-0053 47.3 µM -1.28389717960103 0.0821802340991314 no 3103 0.0995889671200786 4404 6813657 SGTC_131 0141-0277 33.849 µM -1.28405042953304 0.0821551169036907 no 3104 0.0995621554502744 4316 1547771 SGTC_889 0919-1524 82.7 µM -1.28467082950542 0.0820534943317537 no 3105 0.0994536679728739 4369 3905452 SGTC_44 0929-0055 61.211 µM -1.28659717785469 0.0817385587432129 no 3106 0.0991173639385979 4236 1379590 SGTC_583 1488-1091 88.9 µM -1.29051820130935 0.081100333178549 no 3107 0.0984353982038846 4460 4303273 SGTC_3092 9117248 49.47 µM -1.29074822149783 0.0810630098671368 no 3108 0.0983954987951087 4477 17141857 SGTC_577 r071-0003 38.6 µM -1.29316373898761 0.0806718480332182 no 3109 0.0979772170124315 4327 4568517 YMR134W ERG29 SGTC_691 1548-0686 185 µM -1.29320147474909 0.0806657485429448 no 3110 0.0979706928729466 4331 46495133 SGTC_2686 alizarin 95.37 µM -1.29369561956368 0.0805859086619049 no 3111 0.0978852895062463 4337 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1 SGTC_2578 7,8-dihydroxyflavone 64.44 µM -1.29562587100241 0.0802746063002682 no 3112 0.0975522057756431 4227 1880 Intensifies effect of antibiotics on Staphylococcus aureus. SGTC_820 1582-0060 59.9 µM -1.29766745355306 0.0799463388103766 no 3113 0.0972008160812894 4395 3848840 SGTC_358 0075-0058 9.45 µM -1.29888873206328 0.0797504543919567 no 3114 0.0969910585911684 4322 1069125 SGTC_3259 9138485 49.47 µM -1.30206410757801 0.0792428459615999 no 3115 0.096447235782393 4377 17646153 SGTC_2610 ononetin 44.17 µM -1.30401213716378 0.0789326511752025 no 3116 0.0961147220782122 4342 259632 SGTC_551 k048-0028 34.9 µM -1.30420138519469 0.078902565323549 no 3117 0.0960824638634175 4340 6836383 SGTC_349 k015-0014 24 µM -1.30427220206676 0.0788913093905398 no 3118 0.0960703948422159 4377 2196908 SGTC_119 0121-0043 24.815 µM -1.30464808109517 0.0788315859509479 no 3119 0.0960063540217955 4378 1092378 SGTC_2720 fluspirilene 36.88 µM -1.3092061110056 0.0781100841464989 no 3120 0.0952322713844414 4358 3396 An atypical antipsychotic. SGTC_1078 idebenone 36.1 µM -1.30926829937427 0.0781002749519753 no 3121 0.0952217419099335 4404 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen. SGTC_2068 5226020 147 µM -1.31268295934811 0.0775631015411069 no 3122 0.0946449010259354 4381 1810509 SGTC_3052 9092717 49.47 µM -1.31581517317009 0.0770728320178375 no 3123 0.094118042645349 4382 25237534 SGTC_1478 0453-0656 35.7 µM -1.31590432417439 0.0770589122131945 no 3124 0.0941030786106166 4377 5258496 SGTC_323 4013-0906 34.3 µM -1.32060791511165 0.0763272122119123 no 3125 0.0933160661560948 4403 2910086 SGTC_2074 5212007 75.395 µM -1.32266499546633 0.076008875305757 no 3126 0.0929734046519916 4295 758611 SGTC_877 0771-0151 33.1 µM -1.32591791562541 0.0755075445388371 no 3127 0.0924334440098962 4394 6166523 SGTC_2317 5986382 200 µM -1.32603732296127 0.0754891898813132 no 3128 0.0924136675214031 4409 877883 SGTC_308 4092-1169 104 µM -1.32670616291032 0.0753864422341235 no 3129 0.0923029507564544 4338 2268590 YDL196W YDL196W SGTC_2433 5607874 27.82 µM -1.32812253495139 0.0751692101075617 no 3130 0.0920688150043757 4343 2252428 SGTC_3161 9100388 49.47 µM -1.32895944377221 0.0750410760630562 no 3131 0.0919306752289757 4464 25236368 SGTC_2794 7785382 27.27 µM -1.32924122470236 0.0749979717952156 no 3132 0.0918841991594768 4380 2205081 SGTC_2323 6148992 148.28 µM -1.3299037322199 0.0748967018555502 no 3133 0.0917749957922641 4348 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42 SGTC_1963 st076565 50.3 µM -1.3338550712517 0.0742948710848966 no 3134 0.0911256792113996 4406 4914280 SGTC_2957 9076800 11.52 µM -1.33714846679031 0.0737960797371843 no 3135 0.0905870896907597 4363 16459615 SGTC_649 1123-0311 367 µM -1.33790258026536 0.0736822286880541 no 3136 0.0904640979657761 4305 693629 YIL048W NEO1 SGTC_2661 dactinomycin 12.96 µM -1.33968557052276 0.0734135787387128 no 3137 0.0901737953338318 4357 45006140 An Actinomycin D Classic transcription inhibitor. SGTC_903 1134-0042 114 µM -1.3399104193852 0.0733797531643007 no 3138 0.0901372351202371 4393 701009 SGTC_3335 9143315 29.6265 µM -1.34016776992291 0.073341052768616 no 3139 0.0900954036807826 4399 4899691 SGTC_3207 9114163 49.47 µM -1.34484013268402 0.0726411343490054 no 3140 0.0893384334448248 4395 849233 SGTC_244 nsc-207895 1.295 µM -1.34678431543023 0.0723514080796933 no 3141 0.0890248538216626 4171 42640 SGTC_1341 1486-1360 280 µM -1.35189183756342 0.0715944929166703 no 3142 0.0882049595485851 4384 3976547 SGTC_3110 9122132 49.47 µM -1.35510380361071 0.0711216128895979 no 3143 0.0876922435136946 4438 918317 SGTC_928 2764-0428 58.7 µM -1.35617993992828 0.070963716820074 no 3144 0.0875209614852859 4434 662578 SGTC_1724 st037281 8.293 µM -1.36067701513609 0.0703067958601611 no 3145 0.0868078906772765 4374 574124 YDL195W SEC31 SGTC_1266 0828-0227 32.9 µM -1.36215504734462 0.0700919129124968 no 3146 0.0865744794941595 4390 3913820 SGTC_2368 9071271 200 µM -1.38117341888312 0.0673718157857292 no 3147 0.0836128228123167 4394 27209959 SGTC_665 3914-0008 307 µM -1.38255041450688 0.067178084138044 no 3148 0.0834013810339768 4385 1069549 SGTC_1635 st007035 42.4 µM -1.38483821378911 0.0668571628272268 no 3149 0.0830509715898534 4386 3716403 SGTC_2836 9010338 19.48 µM -1.38586637898581 0.066713323698347 no 3150 0.0828938543707886 4396 2994051 SGTC_2479 5617353 43.85 µM -1.39020638029284 0.0661088000648552 no 3151 0.0822331082869042 4431 2731746 SGTC_3102 9121669 49.47 µM -1.39267112121354 0.065767377819199 no 3152 0.0818596326463727 4470 41905072 SGTC_2409 alverine citrate 63.97 µM -1.39548011952332 0.0653799364113156 no 3153 0.0814355528719719 4472 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_1271 0832-2808 169 µM -1.39776536417835 0.0650660436365865 no 3154 0.0810917692341286 4470 3663794 SGTC_137 0438-0332 85.389 µM -1.40713127362504 0.0637917830608595 no 3155 0.0796942330755437 4383 2063393 YER012W | YPR107C PRE1 | YTH1 SGTC_50 0929-0078 56.389 µM -1.40821247864567 0.0636459403176027 no 3156 0.0795340811471521 4287 1377751 SGTC_986 1493-0483 84 µM -1.40910953812327 0.063525133819927 no 3157 0.0794013904613968 4392 40079 SGTC_2695 st077686 51.995 µM -1.40946461571685 0.0634773650446367 no 3158 0.0793489146263691 4423 2876092 SGTC_989 1501-0895 10.3 µM -1.41123808036315 0.0632391983107543 no 3159 0.079087212620691 4421 2830112 SGTC_1486 3970-0793 4.53 µM -1.41546669451171 0.062674125713677 no 3160 0.0784658534320083 4471 2844330 SGTC_3356 9151811 4.48 µM -1.41592998009358 0.06261245649798 no 3161 0.0783980031015913 4451 1859254 YPR165W RHO1 SGTC_1583 clindamycin 39.6 µM -1.41739612235585 0.062417605939942 no 3162 0.0781835728805783 4404 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis. SGTC_3035 9091303 49.47 µM -1.42395778106029 0.0615513482278878 no 3163 0.0772293469247855 4523 25237002 SGTC_1994 st072947 40.9 µM -1.42774202811919 0.0610560447360884 no 3164 0.0766830621930891 4493 5286565 YDL195W SEC31 SGTC_2657 nystatin 74.44 µM -1.42780173255848 0.0610482553217058 no 3165 0.0766744670131555 4475 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_1203 3992-3522 103 µM -1.4313998859862 0.0605802501495677 no 3166 0.0761578205334139 4523 5322312 SGTC_2428 5615643 7.78 µM -1.43569660981784 0.060025065539582 no 3167 0.0755443451733009 4440 2253075 SGTC_1723 st034307 2.5525 µM -1.44056565353368 0.0594007551653966 no 3168 0.0748537147892421 4452 867466 SGTC_1830 st055982 50.3 µM -1.44136553789353 0.059298682304603 no 3169 0.0747407204481643 4462 455313 An antimicrobial agent. SGTC_2698 st077697 67.5 µM -1.44139423198528 0.0592950232221457 no 3170 0.0747366694442941 4436 3154499 SGTC_3011 9081274 71.4286 µM -1.44753707787813 0.0585157526017557 no 3171 0.0738732798119407 4468 6625322 SGTC_2618 avocadyne 43.43 µM -1.44939904618419 0.0582811415005547 no 3172 0.0736130874533261 4396 3015189 SGTC_2505 galangin 7.89 µM -1.45012636825484 0.0581896986452562 no 3173 0.0735116416264982 4360 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_1378 2093-0007 380 nM -1.45061954024726 0.0581277585563847 no 3174 0.0734429155562402 4508 3618014 SGTC_664 1222-0054 14.9 µM -1.452571707978 0.0578830837116471 no 3175 0.0731713530317786 4435 6813991 SGTC_2290 7904846 200 µM -1.45382635511385 0.0577262604220832 no 3176 0.0729972273282509 4505 2962154 SGTC_143 4032-1194 15.74 µM -1.45799608939985 0.0572074681112166 no 3177 0.0724208104610146 4496 1806963 SGTC_1632 st005650 90 µM -1.46115370603071 0.0568170491091071 no 3178 0.0719866321577982 4488 2759605 SGTC_2347 9049783 174.81 µM -1.46225617891532 0.0566812307389278 no 3179 0.0718355110025865 4454 6467988 YPL169C MEX67 SGTC_1859 st055998 20 µM -1.46694323578374 0.0561066651135045 no 3180 0.0711957488347001 4402 676301 SGTC_1211 1056-0033 32.3 µM -1.4760395231478 0.0550047059450629 no 3181 0.069966641216276 4514 6741922 SGTC_2833 9001315 45.46 µM -1.47986310324866 0.0545466385409606 no 3182 0.0694548920435237 4429 2989378 SGTC_2762 leflunomide 42.06 µM -1.48334616238699 0.0541319963881697 no 3183 0.0689912317415474 4462 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1 SGTC_2029 5175081 200 µM -1.48811284025947 0.0535685927936748 no 3184 0.068360568889264 4450 1380876 SGTC_1042 0350-0096 82 µM -1.49264945638291 0.0530367059920517 no 3185 0.0677644851279674 4483 3122515 SGTC_261 5-fluorouridine 15.376 µM -1.49366910558831 0.0529177375282682 no 3186 0.0676310636490746 4507 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_1943 st076331 65.2 µM -1.4966909472191 0.0525664043746632 no 3187 0.067236846452697 4479 24208415 SGTC_2557 derrustone 83.84 µM -1.49710423017623 0.0525184984502214 no 3188 0.0671830696195007 4465 629853 An antioxidant. SGTC_1393 3470-5649 58.2 µM -1.49805866765261 0.0524079967226647 no 3189 0.0670590042558587 4487 4108395 SGTC_2036 5160441 105 µM -1.50338749447379 0.051794430490049 no 3190 0.0663695747519586 4467 134534 YIL048W NEO1 SGTC_627 1391-0720 175 µM -1.50630661685617 0.0514607483108559 no 3191 0.0659942401569832 4476 997839 SGTC_905 2-aminofluorene 215 µM -1.51624560149447 0.0503374361150194 no 3192 0.0647286305880535 4505 1539 An established DNA mutagen. YPR165W RHO1 SGTC_1336 1486-0901 104 µM -1.52728629773478 0.0491126103407713 no 3193 0.0633449176084762 4515 5006114 SGTC_1387 3342-1166 1.8 µM -1.52801261493219 0.0490328765088505 no 3194 0.0632547029526029 4498 3418228 SGTC_1162 k048-0130 20.1 µM -1.52905536649688 0.0489185859032349 no 3195 0.0631253594494391 4504 6797406 SGTC_193 1273-0060 1.558 µM -1.53338109120606 0.04844673687461 no 3196 0.0625909924589008 4364 2847393 YHR072W ERG7 SGTC_929 2805-0021 398 µM -1.53494562849989 0.0482769764719453 no 3197 0.0623985921011077 4536 3098024 SGTC_532 1548-0774 215 µM -1.53741724234076 0.0480097635858443 no 3198 0.0620955833444972 4579 5932993 SGTC_158 k038-0087 26.446 µM -1.53774488996496 0.0479744297459041 no 3199 0.0620555015423371 4430 X158 SGTC_1791 st048313 56.1 µM -1.54200222807952 0.0475172040194514 no 3200 0.061536526080851 4528 1204976 SGTC_1473 k844-0725 134 µM -1.5421889490777 0.0474972309157497 no 3201 0.0615138423587082 4559 54682906 SGTC_1202 1988-0068 29.6 µM -1.54628796270751 0.0470604611639891 no 3202 0.0610175188856917 4492 2850480 SGTC_461 N-acetylfarnesylcysteine 136 µM -1.54927821387388 0.0467438714949069 no 3203 0.0606574272986478 4581 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ). SGTC_2142 5622915 118.518 µM -1.55631330905598 0.0460057752917418 no 3204 0.0598168040850214 4532 5322196 SGTC_89 0302-0250 142.109 µM -1.55699346068436 0.0459349154519299 no 3205 0.0597360189989524 4597 4203518 YLR208W SEC13 SGTC_1664 st014217 9.02 µM -1.5606023525863 0.0455603982048512 no 3206 0.0593088016756161 4596 3982782 SGTC_1127 asiatic acid 681.4 nM -1.5642108692147 0.0451883786034164 no 3207 0.0588840277445866 4473 470603 A kinase inhibitor which arrests cells at G2/M. SGTC_3235 9132602 49.47 µM -1.5722445857239 0.0443689200348265 no 3208 0.0579469194827038 4511 4912240 SGTC_2364 9055074 200 µM -1.57337370121474 0.0442547133961392 no 3209 0.057816156407708 4521 6470630 SGTC_1318 1280-3875 124 µM -1.57470623096603 0.0441202369666957 no 3210 0.0576621344535217 4553 373245 SGTC_2621 lithochol-11-enic acid 100 µM -1.57503273140904 0.0440873374490763 no 3211 0.0576244447915892 4484 6708711 SGTC_3223 9129970 49.47 µM -1.57933544161734 0.0436556240095271 no 3212 0.057129568321028 4554 17248386 SGTC_1358 1509-0022 2.48 µM -1.58356331251464 0.0432347487995753 no 3213 0.0566465641303588 4564 3258434 SGTC_932 2857-0803 154 µM -1.58502145018091 0.0430903566449444 no 3214 0.0564807303845545 4534 674898 SGTC_157 1348-1695 65.819 µM -1.58922353444335 0.0426764228886359 no 3215 0.0560049674870357 4460 5380510 SGTC_999 SEC7.066 22.7 µM -1.59090823127959 0.0425113742056962 no 3216 0.055815114921692 4498 740511 YDR170C SEC7 SGTC_20 0481-0013 4.944 µM -1.59398325362153 0.0422114474490697 no 3217 0.0554698928843632 4597 182045 SGTC_1983 st071813 46.9 µM -1.5970900030554 0.0419101672976489 no 3218 0.0551228231293945 4605 11838595 SGTC_615 k087-0205 167 µM -1.59765994459029 0.0418550860933842 no 3219 0.0550593388777536 4558 9642773 SGTC_725 1497-0963 19 µM -1.60794963436357 0.0408706973489181 no 3220 0.0539231049824532 4604 3549977 SGTC_2824 7998404 51.95 µM -1.60869120348401 0.0408004850444928 no 3221 0.0538419401064155 4527 837851 SGTC_690 glyoxal 20.3 µM -1.61165649335798 0.0405207067198273 no 3222 0.0535183549832754 4355 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins. SGTC_2419 paclitaxel 166.5 µM -1.6180932789817 0.0399187478280423 no 3223 0.0528212483686757 4491 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_147 4466-0538 29.23 µM -1.62043102907529 0.0397019321587301 no 3224 0.0525698594738741 4580 6742687 YHR072W ERG7 SGTC_1975 st070967 30.8 µM -1.62957008903339 0.0388634971897494 no 3225 0.0515961951790005 4561 261391 SGTC_3123 9126162 49.47 µM -1.63406866405105 0.0384561169691554 no 3226 0.0511222168539254 4557 25239884 SGTC_628 1636-0253 16 µM -1.63627554877483 0.038257543088948 no 3227 0.0508909655371676 4554 4456143 SGTC_3140 9094243 49.47 µM -1.64383578129607 0.037583608345406 no 3228 0.0501050640703054 4524 19291112 SGTC_1457 k015-0032 57.3 µM -1.6476943513916 0.0372434017369896 no 3229 0.0497077038790336 4567 4302660 SGTC_47 0149-0135 24.25 µM -1.65259566348641 0.0368148897983115 no 3230 0.0492065906200712 4580 5239155 SGTC_1871 st057448 67.3 µM -1.65840522183793 0.0363122021751213 no 3231 0.0486178516629966 4565 691747 SGTC_1286 0929-0070 131 µM -1.65842586768228 0.0363104258078288 no 3232 0.0486157695058123 4615 1420408 SGTC_679 0422-0091 41.4 µM -1.65976200310838 0.0361956159645656 no 3233 0.0484811702390411 4593 627384 YHR062C RPP1 SGTC_2028 5153890 36.43 µM -1.66290920820941 0.0359263609735427 no 3234 0.0481653054420828 4561 2830968 YPR165W RHO1 SGTC_623 k072-0108 16.9 µM -1.66374097164682 0.0358554753246993 no 3235 0.0480821023583962 4547 5382803 SGTC_189 3970-0742 2.116 µM -1.67177031989199 0.035177062959587 no 3236 0.0472848107903821 4557 2891807 SGTC_578 3460-0051 92 µM -1.6722803934739 0.0351343242108112 no 3237 0.0472345220057284 4612 2876744 SGTC_2938 9059746 27.26 µM -1.67989793345894 0.0345011092835634 no 3238 0.0464885879797834 4556 6471769 SGTC_2791 5663188 71.43 µM -1.68047016884218 0.034453922752244 no 3239 0.0464329368329929 4580 54690634 SGTC_1827 berberine 7.24 µM -1.68140583475168 0.0343768819804891 no 3240 0.0463420564900167 4492 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_855 0428-0020 25 µM -1.68333212836768 0.0342187206898251 no 3241 0.0461554070726058 4607 6812414 SGTC_472 calcifediol 10 µM -1.69656764912792 0.0331481019151353 no 3242 0.0448892151850978 4619 5283731 A vitamin D metabolite. SGTC_3053 9095903 49.47 µM -1.69660093284354 0.0331454447946804 no 3243 0.044886066671098 4682 17174018 SGTC_1940 st075990 51.1 µM -1.70249435932354 0.032677716854405 no 3244 0.0443313674893589 4614 1084979 SGTC_1781 st038725 66.3 µM -1.70332354668585 0.0326123478221398 no 3245 0.0442537682046296 4591 4270275 YIL048W NEO1 SGTC_1870 st057514 26.5 µM -1.70619858746037 0.0323865285506153 no 3246 0.0439855558295603 4591 5393161 SGTC_2178 5812956 200 µM -1.70830828320264 0.0322216451066366 no 3247 0.0437895775775871 4567 5403383 SGTC_3276 9139060 49.47 µM -1.71323217898823 0.031839512129873 no 3248 0.0433349169151477 4656 4870619 SGTC_638 3970-0837 4.09 µM -1.71680235323194 0.0315647861625872 no 3249 0.0430076454262855 4588 4118451 YLR208W SEC13 SGTC_1109 tnp00067 928.257 nM -1.72215816342091 0.0311563315544799 no 3250 0.0425204355960625 4596 676295 SGTC_325 2810-4341 181 µM -1.72415665902973 0.0310050430849829 no 3251 0.0423397829611004 4597 774970 SGTC_1986 st071812 45 µM -1.72736959512173 0.0307630946120884 no 3252 0.0420506537744748 4559 11838594 SGTC_3051 9093778 49.47 µM -1.72774430484724 0.030734979349636 no 3253 0.0420170382959395 4689 17217378 SGTC_2475 5812728 15.03 µM -1.7301185422249 0.0305573293700523 no 3254 0.0418045490114576 4556 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2 SGTC_1328 1441-0025 69.2 µM -1.75381778902527 0.0288302393785686 no 3255 0.0397308669567748 4638 4562601 SGTC_997 3996-0078 137 µM -1.75816006977279 0.0285227607342466 no 3256 0.039360138619253 4646 735687 SGTC_560 2332-1943 155 µM -1.7619681420266 0.0282553594485095 no 3257 0.0390373401236697 4616 21177716 SGTC_2366 9070441 60.58 µM -1.76313605401909 0.028173768466097 no 3258 0.0389387728349608 4576 6837235 SGTC_2195 6536160 144.242 µM -1.77966484040577 0.0270399383143049 no 3259 0.0375654138945966 4626 3834386 SGTC_1801 st050089 28.441 µM -1.78076371585461 0.0269659281662202 no 3260 0.0374755296425231 4650 5008493 YIL048W | YNL267W NEO1 | PIK1 SGTC_676 falcarinol 140 µM -1.78478010209025 0.0266968582588847 no 3261 0.0371484960411375 4635 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer. SGTC_1831 st055328 12 µM -1.78531432699633 0.0266612384552016 no 3262 0.037105173129316 4599 1103068 SGTC_1006 4099-6547 255 µM -1.79544272634368 0.0259933962303039 no 3263 0.0362915951058723 4628 3146833 SGTC_655 k060-0012 42 µM -1.79903355927021 0.0257600106508856 no 3264 0.0360066861541872 4631 5994525 SGTC_969 1313-0238 134 µM -1.80092842388375 0.0256375628244508 no 3265 0.035857081124212 4644 5212874 SGTC_334 1502-1024 68.5 µM -1.80601248024332 0.0253114321028886 no 3266 0.0354581950790929 4633 3296216 SGTC_2111 5486399 200 µM -1.82116596141595 0.0243599240295817 no 3267 0.0342908164780804 4595 689674 SGTC_558 k064-0027 21.3 µM -1.82228684212307 0.0242907513755039 no 3268 0.034205736813523 4637 5088526 SGTC_593 1203-0218 61.7 µM -1.83531979419857 0.0234984901659589 no 3269 0.0332291599350529 4680 3666956 SGTC_400 oxethazaine 37.5 µM -1.84207007975952 0.0230967653264743 no 3270 0.0327324498432445 4659 4621 A local anesthetic. SGTC_817 1391-0715 46 µM -1.84419100611895 0.0229717443582404 no 3271 0.032577654318448 4630 1353946 SGTC_1214 0358-0031 63.7 µM -1.84424449542282 0.0229685987400075 no 3272 0.0325737582279373 4641 4301366 SGTC_1568 digitonin 820 nM -1.84494934602226 0.0229271815122193 no 3273 0.0325224537272396 4611 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1 SGTC_1676 st018489 23.4 µM -1.84972279424679 0.0226483448858022 no 3274 0.0321767567163611 4599 3696235 SGTC_2319 6033012 152.6 µM -1.85133716199664 0.0225546922659821 no 3275 0.0320605315030441 4592 847246 SGTC_965 1291-5240 308 µM -1.85546290354641 0.0223168323865853 no 3276 0.0317650759522017 4634 2834598 SGTC_2965 9082772 38.63 µM -1.85728167144138 0.022212649626572 no 3277 0.0316355453272775 4617 16459634 SGTC_1361 1608-0041 5.61 µM -1.87150863162155 0.0214117757997755 no 3278 0.0306373072971482 4664 X1361 SGTC_3023 9089636 49.47 µM -1.87397962079378 0.0212751955677039 no 3279 0.0304666170237398 4706 17249241 SGTC_2185 6113692 200 µM -1.88037683189224 0.0209250181371214 no 3280 0.0300283693866508 4644 874150 SGTC_3258 9138477 49.47 µM -1.88247050783948 0.0208114770704837 no 3281 0.0298860802665966 4684 4970355 SGTC_1842 st055362 61.2 µM -1.88662660876986 0.0205876346247409 no 3282 0.0296052826157326 4643 676032 SGTC_1274 0865-0114 173 µM -1.90034015616467 0.0198634539141237 no 3283 0.0286942474035327 4653 870624 SGTC_2580 diallyl disulphide 81.36 µM -1.90042802216572 0.0198588845258751 no 3284 0.0286884862105805 4619 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.  SGTC_1820 st053765 18.6 µM -1.91920926999903 0.0189024418602531 no 3285 0.0274789274150367 4685 3690829 SGTC_2326 6164455 177.58 µM -1.93885909627365 0.0179439964419848 no 3286 0.0262592489125158 4591 2888790 SGTC_2105 5350118 200 µM -1.94719258538195 0.0175502123837194 no 3287 0.0257558251445204 4647 2133313 SGTC_286 k060-0067 22.9 µM -1.95222288389633 0.0173161034801203 no 3288 0.0254558742119389 4702 5985051 SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM -1.96460878212241 0.016751009462883 no 3289 0.0247297673710112 4611 5355888 SGTC_98 0074-0023 107.663 µM -1.96862740729851 0.0165710863731503 no 3290 0.0244979464553659 4680 3563821 SGTC_275 trichlorophene 5.69 µM -1.96931773743969 0.0165403457625037 no 3291 0.0244583077924901 4696 62616 SGTC_1511 0906-3109 28.5 µM -1.97219156256291 0.0164128974565826 no 3292 0.0242938712508199 4668 2882180 SGTC_2173 5763948 167 µM -1.98243116194638 0.015965604717588 no 3293 0.02371550238453 4657 2867177 SGTC_2389 9091542 195.52 µM -1.98357412941634 0.0159163313130714 no 3294 0.0236516678023982 4651 3626624 YOL127W RPL25 SGTC_370 0180-0345 38.7 µM -2.00483285896714 0.0150233531172383 no 3295 0.0224904592181664 4576 3989527 SGTC_1419 3993-2473 62.6 µM -2.01158453842414 0.0147489096364109 no 3296 0.0221318753050145 4736 704026 SGTC_1681 tripelennamine 100 µM -2.01423334780322 0.014642424147269 no 3297 0.021992520019995 4626 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist. SGTC_3318 9139014 38.6185 µM -2.01518982779847 0.0146041353352329 no 3298 0.021942381475348 4669 16643984 SGTC_971 1315-0384 26.7 µM -2.01547925091234 0.0145925664428074 no 3299 0.0219272289909682 4697 6769120 SGTC_678 1218-2179 85.9 µM -2.02246317710216 0.0143157847538937 no 3300 0.0215642620109005 4713 6820081 YOR116C RPO31 SGTC_32 0928-0142 34.1 µM -2.02867722548948 0.0140733272355128 no 3301 0.0212455885274454 4697 2244242 SGTC_2191 5911152 200 µM -2.03252495913738 0.0139249786118737 no 3302 0.0210502698268398 4697 2875902 SGTC_1032 k061-1018 98.7 µM -2.0530993010228 0.0131544118983617 no 3303 0.020031473874637 4718 4005393 SGTC_1537 2',6'-dihydroxyflavanone 78 µM -2.07643106957255 0.0123254191826245 no 3304 0.0189270500925692 4716 5106787 A p450 inhibitor. SGTC_282 k297-0036 65.7 µM -2.07831472636265 0.0122605106769487 no 3305 0.0188401904817941 4694 5061378 SGTC_2869 9037858 32.47 µM -2.08880961897102 0.0119042653174721 no 3306 0.018362432095653 4676 27187042 SGTC_3319 9138450 16.7555 µM -2.11014477575704 0.0112076434002489 no 3307 0.0174229437718954 4676 2029690 SGTC_3327 9140648 26.9345 µM -2.1117632436043 0.0111562747094508 no 3308 0.0173533807149142 4726 8029710 SGTC_1539 benzyladenosine 56 µM -2.11703413011096 0.0109903979921774 no 3309 0.0171284756395527 4738 92208 A nucleotide analog. SGTC_1196 1588-0294 184 µM -2.13738884972207 0.0103698067181463 no 3310 0.0162831887854537 4739 6144269 SGTC_1742 st038235 28.8875 µM -2.13856250718432 0.0103349738200897 no 3311 0.0162355583546804 4716 564103 YBR002C RER2 SGTC_1331 1472-0049 76.2 µM -2.15551981851022 0.00984296748699096 no 3312 0.0155605897322486 4715 24051409 SGTC_1159 4092-0538 61.2 µM -2.17661755212323 0.00925947931952237 no 3313 0.0147545572340236 4742 717301 SGTC_295 k015-0027 31 µM -2.20955702224152 0.00840897003176927 no 3314 0.0135679604168493 4747 3887424 SGTC_853 0419-0306 21 µM -2.22084841030371 0.00813363023447712 no 3315 0.0131806152184137 4755 762713 SGTC_3046 9092212 49.47 µM -2.25860535053598 0.00726961864780291 no 3316 0.0119539723490153 4755 25236637 SGTC_1992 st073643 23.3 µM -2.27722352132483 0.00687416304507936 no 3317 0.011386440612082 4740 3161292 SGTC_329 k048-0121 21.3 µM -2.28400890719906 0.00673483502239446 no 3318 0.0111855037358225 4738 6832902 SGTC_1466 k213-0079 57.5 µM -2.31132850123433 0.00619879390582781 no 3319 0.0104073584471902 4756 3657981 SGTC_2247 cerulenin 830 nM -2.35129878922652 0.00548260249369352 no 3320 0.00935400232471761 4754 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12 SGTC_1551 6-bromo-3'-methylflavone 63.5 µM -2.35425525667795 0.00543267190087936 no 3321 0.00927993061569716 4747 688751 SGTC_226 1,3-diallylurea 8.28947 mM -2.35938718056419 0.00534695992888502 no 3322 0.00915257297070492 4744 74537 YKL182W FAS1 SGTC_2924 9010168 62.78 µM -2.36313392280743 0.00528514442730662 no 3323 0.00906055991719984 4720 2993929 SGTC_2184 6075246 200 µM -2.3855865281219 0.00492785293387165 no 3324 0.00852595523043601 4750 2267320 SGTC_2983 9022671 12.99 µM -2.41476806370159 0.00449571606240484 no 3325 0.00787261612677656 4745 6405161 SGTC_2987 9018338 71.43 µM -2.4192052899905 0.00443305874103856 no 3326 0.00777722954737954 4746 5055682 SGTC_2360 9040895 200 µM -2.41921071687749 0.00443298258892435 no 3327 0.00777711351158294 4748 4914414 SGTC_642 0335-0876 158 µM -2.43149917193579 0.00426351409838359 no 3328 0.0075182413461862 4773 6812350 SGTC_2166 5933061 31.504 µM -2.4463481420173 0.00406647831786533 no 3329 0.00721557881938161 4704 2877375 SGTC_1144 3486-0183 12.5 µM -2.46217918677253 0.00386542490466726 no 3330 0.0069047827396791 4777 6744069 SGTC_2026 5148700 152 µM -2.47651340115168 0.00369111480203805 no 3331 0.0066336322115631 4758 79838 SGTC_271 rotenone 740 µM -2.48911403043403 0.00354374508458782 no 3332 0.00640309421498309 4766 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria. SGTC_289 k017-0060 526 µM -2.5468818416603 0.00293353779838155 no 3333 0.0054345114158783 4767 5512909 SGTC_722 3534-0461 190 µM -2.55665352013781 0.00284024016596223 no 3334 0.00528422126342759 4761 658262 SGTC_1534 6-azauridine 81.6 µM -2.57904125539795 0.00263649999644186 no 3335 0.00495374767806826 4784 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1 SGTC_662 k832-1615 104 µM -2.59052798821994 0.00253717415175581 no 3336 0.00479144143993197 4775 5878478 SGTC_52 0329-0193 875 nM -2.59118291715789 0.00253161425387177 no 3337 0.00478233189899769 4756 3739292 SGTC_26 0302-0163 425.158 µM -2.6191703860027 0.0023040700379518 no 3338 0.00440719546738891 4794 3100915 SGTC_2159 5658611 73.75 µM -2.64973229865987 0.00207688456785373 no 3339 0.0040277785976903 4769 793844 SGTC_2412 st077135 33.4 µM -2.67350327617015 0.00191444921731379 no 3340 0.0037531771498526 4752 13258915 SGTC_53 0973-0023 39.979 µM -2.688300086215 0.00181925658687379 no 3341 0.00359084120902616 4735 674768 SGTC_2138 5575593 77.673 µM -2.69189215774161 0.00179680662721682 no 3342 0.00355239574997096 4785 762213 SGTC_2784 7567673 72.73 µM -2.69713775072919 0.00176447487822334 no 3343 0.0034969166264491 4737 3471247 SGTC_1298 1079-1278 263 µM -2.7058527568461 0.00171192746444782 no 3344 0.0034064623261143 4769 2840950 SGTC_2979 9012552 45.46 µM -2.81553006087398 0.00116195431212276 no 3345 0.00243484204473431 4779 17100905 SGTC_2984 9022109 38.96 µM -2.90917709495006 0.000826035870827617 yes 3346 0.00181190760021376 4783 6459207 SGTC_2416 tofa 880 nM -2.91398154786299 0.000811492158395802 yes 3347 0.00178425499228201 4762 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_236 1509-0011 5.31 µM -2.96605638215244 0.000668290657519516 yes 3348 0.00150822592079757 4794 3107280 SGTC_2417 cerulenin 830 nM -3.16492917140006 0.000309812777684627 yes 3349 0.000775603535010684 4785 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1 SGTC_2137 5261020 140 µM -3.24178729966442 0.000227520481700844 yes 3350 0.000593913198073571 4803 763655 SGTC_372 0155-0182 15.9 µM -3.52333921282542 6.9452095108183e-05 yes 3351 0.000213072786433152 4708 771486 SGTC_1147 3809-1045 12.3 µM -3.59811276420102 4.99367799232704e-05 yes 3352 0.000160267324490512 4803 325925 SGTC_2240 6690706 185.951 µM -3.81962391637386 1.81203570932891e-05 yes 3353 6.68276509316682e-05 4785 805876