SGTCid condition conc unit YGR050C|YGR050C.score YGR050C|YGR050C.strain.pval YGR050C|YGR050C.strain.significant YGR050C|YGR050C.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene SGTC_2337 9009472 200 µM 8.75902987012747 1.9938194357495e-19 yes 1 9.84689659946665e-19 1 5742383 SGTC_2338 7999974 200 µM 7.25177080856094 6.35512527650775e-14 yes 2 2.05678775277829e-13 1 315925 SGTC_996 3970-0799 1.8 µM 6.46897451059896 1.85131762084396e-11 yes 3 4.93351184040557e-11 29 6615648 YGL040C HEM2 SGTC_3333 9141820 12.094 µM 5.64140389942292 3.81412984580983e-09 yes 4 8.43345867266134e-09 5 1939433 SGTC_3088 9117578 49.47 µM 5.36732191037081 1.91417202409268e-08 yes 5 3.99571755610348e-08 3 678341 SGTC_1930 st074634 34.3 µM 4.72097236553046 6.3854979947278e-07 yes 6 1.17359915283661e-06 21 684253 YOR116C RPO31 SGTC_2134 5324836 1.464 µM 4.01707333610322 1.81673692873749e-05 yes 7 2.9462695352177e-05 14 699272 SGTC_3052 9092717 49.47 µM 3.97448563949537 2.19009906013715e-05 yes 8 3.52657587246897e-05 26 25237534 SGTC_223 busulfan 5 mM 3.76230912211903 5.41204756068901e-05 yes 9 8.41758929336774e-05 10 2478 A DNA alkylator. SGTC_891 0929-0073 133 µM 3.75724579539663 5.52718274164038e-05 yes 10 8.58968683461797e-05 29 5603632 SGTC_3072 9116419 49.47 µM 3.73644816267906 6.02478263103434e-05 yes 11 9.33189513762368e-05 23 17170162 SGTC_2349 9023730 187.07 µM 3.69394236704182 7.17603890073571e-05 yes 12 0.000110401933554633 34 4126287 SGTC_3250 9135583 49.47 µM 3.68327423622086 7.49591827057631e-05 yes 13 0.000115128607582633 14 7699353 SGTC_2334 9017922 200 µM 3.65287403417479 8.48266723583368e-05 yes 14 0.000129660730877559 32 3163164 SGTC_2841 9004761 38.96 µM 3.63727128337037 9.03536206297894e-05 yes 15 0.000137770839479555 41 2991039 SGTC_792 4534-1957 155 µM 3.547560711761 0.000129289383450049 yes 16 0.000194408064183264 54 1717904 SGTC_1108 betulinic acid 729.144 nM 3.49087866373499 0.000161485446299386 yes 17 0.000240717422011776 25 64945 Apoptosis-inducing agent of unknown mechanism. SGTC_3316 9136639 10.545 µM 3.44231267248034 0.000194893724412874 yes 18 0.000288381588155275 24 4903665 SGTC_2909 7941780 10.49 µM 3.43941246491855 0.000197080262132906 yes 19 0.000291489140049065 38 1243215 SGTC_2457 5731572 11.68 µM 3.36887298036566 0.00025786948887847 yes 20 0.000377381011423928 25 2865357 SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM 3.2658367935739 0.000378603177612404 yes 21 0.000545705664415237 45 688761 SGTC_252 miconazole 1.30953 nM 3.25340818972119 0.000396279033791554 yes 22 0.00057014783342677 63 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_776 4476-4378 112 µM 3.20224710037843 0.000477411753647253 yes 23 0.00068179987218884 46 2892008 SGTC_2962 9082311 13.18 µM 3.18434008310493 0.000509268995854257 yes 24 0.000725422251401088 54 16459453 SGTC_1104 tacrolimus 29.8 µM 3.08302423221609 0.000729706383324503 yes 25 0.00102454234393859 66 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41 SGTC_2701 st077767 14.721 µM 3.07702587454612 0.000745180519616001 yes 26 0.00104538575774889 91 5721188 SGTC_1988 st071872 53.4 µM 3.05656336316735 0.000800271559214914 yes 27 0.00111945077071799 39 16414116 SGTC_1325 1431-0015 227 µM 3.04991136564905 0.000818972803336372 yes 28 0.00114454455245996 47 1103340 SGTC_1199 1638-0010 4.46 µM 3.03863729376455 0.000851589213674863 yes 29 0.00118825394446772 67 3111136 SGTC_1019 4262-0212 3.4 µM 2.93934404742047 0.00119487066231127 no 30 0.00164453873643308 138 4677213 SGTC_3256 9138902 49.47 µM 2.86549758990182 0.00152777300932148 no 31 0.00208177221110712 12 17228773 SGTC_2316 5844804 197.44 µM 2.86042700342048 0.001553477269497 no 32 0.00211535468723047 112 776813 SGTC_1552 6-methylflavone 10.6 µM 2.84853448903087 0.00161531785255556 no 33 0.00219605462971782 48 689013 SGTC_2222 6885208 172.143 µM 2.81848366380347 0.00178170293004121 no 34 0.00241255331421825 22 609514 SGTC_1659 st012954 42.1 µM 2.81318140545983 0.00181262922363005 no 35 0.00245269844924918 54 24207262 SGTC_3326 9140064 16.379 µM 2.80694130050673 0.00184965055582492 no 36 0.00250071772616876 70 1868434 SGTC_3240 9133527 49.47 µM 2.80228083640359 0.0018777471670327 no 37 0.0025371340223887 60 17617455 SGTC_3329 9141233 27.5565 µM 2.77931494752655 0.00202195032007516 no 38 0.00272368406171522 70 4909101 YNL103W MET4 SGTC_643 k048-0106 28.4 µM 2.77093671439048 0.00207701134904576 no 39 0.00279476446706728 58 6763920 SGTC_2557 derrustone 83.84 µM 2.75294704905064 0.00219986077165494 no 40 0.00295307240151491 114 629853 An antioxidant. SGTC_809 3998-0021 90 µM 2.75074706104162 0.00221532771993025 no 41 0.00297297676292343 48 715485 SGTC_787 4152-0075 138 µM 2.74833694316842 0.00223238504640114 no 42 0.00299492097414677 75 9566539 SGTC_2972 9093619 59.92 µM 2.73419832242426 0.00233486841598175 no 43 0.00312661839184218 83 25236256 SGTC_1288 0973-0013 65.5 µM 2.73402557663675 0.00233614647868873 no 44 0.00312825921571315 70 4315430 SGTC_2903 5923464 63.88 µM 2.71140536779673 0.00250907784042694 no 45 0.00334993311891358 45 2876576 SGTC_1464 k208-0027 110 µM 2.71044295968496 0.00251668577424183 no 46 0.00335967023899453 84 X1464 SGTC_904 1141-0088 396 µM 2.68227453903783 0.00274880681948068 no 47 0.00365617115087652 84 1378119 SGTC_2949 9072542 2.23 µM 2.67810248161216 0.00278478299719461 no 48 0.00370202803383326 129 16457352 SGTC_1425 4048-4433 7.33 µM 2.65148307087866 0.00302450146822311 no 49 0.00400695651847245 126 23734946 SGTC_231 b-estradiol 524 µM 2.640965033761 0.00312423509692815 no 50 0.00413351255047821 51 450 A steroid. SGTC_1993 st073995 70.8 µM 2.61549999525124 0.00337806759227748 no 51 0.00445484612390584 84 3098394 SGTC_915 methyl methanesulfonate (MMS) 110 mM 2.60050243105705 0.00353609234547047 no 52 0.00465436797397195 124 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks. SGTC_463 ikarugamyin 104 µM 2.54864801484602 0.0041348810795195 no 53 0.00540706928217527 32 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis. SGTC_714 4296-0578 26.1 µM 2.5213152868977 0.00448570974056052 no 54 0.0058458520533684 32 1589775 SGTC_3239 9133757 49.47 µM 2.51708390252381 0.00454233550239708 no 55 0.00591653233626675 39 17036923 SGTC_284 0988-0104 32.6 µM 2.50096029411311 0.00476400057497637 no 56 0.0061928531933993 88 4666532 SGTC_1136 pergolide 1.05886 µM 2.49504959684245 0.00484764526630432 no 57 0.00629697629055486 177 47811 A dopamine receptor agonist. SGTC_3315 9136395 68.55 µM 2.44952568614006 0.00553697239494492 no 58 0.00715222533619942 109 16876844 SGTC_548 1436-0017 110 µM 2.41555093757357 0.00610681582024251 no 59 0.00785571237690109 169 9677137 SGTC_712 r015-0009 80.6 µM 2.41372735436669 0.00613882126969805 no 60 0.00789513657028016 103 6813872 YLR060W FRS1 SGTC_2882 9058044 58.44 µM 2.40989413715519 0.00620658242001822 no 61 0.00797857496833121 112 18076804 SGTC_1920 st075728 45.7 µM 2.40690119541516 0.00625994940745654 no 62 0.00804426095705061 139 3400306 SGTC_2892 9047358 58.44 µM 2.40052461314531 0.00637500684883526 no 63 0.00818579485313467 78 6466771 SGTC_596 1155-0152 116 µM 2.37277545308905 0.00689778563022152 no 64 0.00882749670178733 183 280313 SGTC_272 doxorubicin 8.13 µM 2.35210314659202 0.00731149368246614 no 65 0.00933379881126501 175 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_830 4076-0286 57.8 µM 2.35004417334725 0.00735387346031224 no 66 0.00938559161947102 275 6866659 SGTC_617 3770-0098 35 µM 2.3481565535687 0.00739291636049183 no 67 0.0094332947877549 111 5962639 SGTC_1933 st074711 15.9 µM 2.34449775615189 0.00746911421700858 no 68 0.0095263625839292 185 17250958 SGTC_1863 st057641 20.1 µM 2.33622877704234 0.00764387723291395 no 69 0.00973966062640096 137 3921635 SGTC_392 N-ethylmaleimide 8.33 µM 2.32585703451906 0.00786816448098237 no 70 0.0100130893959375 134 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides. SGTC_2615 purpurogallin-4-carboxylic acid 100 µM 2.32379826937455 0.00791336725165385 no 71 0.0100681542732031 209 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase. SGTC_292 k038-0015 474 µM 2.31711712297775 0.00806163727323822 no 72 0.0102486762507784 113 46368540 SGTC_532 1548-0774 215 µM 2.31588269307236 0.00808929779736798 no 73 0.0102823372663404 144 5932993 SGTC_1362 1611-0397 101 µM 2.30980351324219 0.00822673752719722 no 74 0.0104495173578356 137 27816 SGTC_528 3492-0019 172 µM 2.30243646210776 0.0083960396252193 no 75 0.0106552853578814 415 2869262 SGTC_2076 5212012 200 µM 2.30167737934829 0.00841365670881127 no 76 0.0106766863941762 72 604802 SGTC_1238 0333-0287 48.8 µM 2.30031781701381 0.00844529106818682 no 77 0.0107151104969153 160 7226 SGTC_3128 9127691 49.47 µM 2.29358701331088 0.00860344628469102 no 78 0.0109071160273664 129 41316314 SGTC_3126 9127922 49.47 µM 2.28383580978054 0.00883717960749569 no 79 0.0111905911279703 185 45595682 SGTC_2833 9001315 45.46 µM 2.27920135318689 0.00895020408116224 no 80 0.0113275493516613 200 2989378 SGTC_3073 9114972 49.47 µM 2.26139784507803 0.00939625436910937 no 81 0.0118673160449414 128 41905075 SGTC_909 3448-9333 149 µM 2.25553509148959 0.00954733675470661 no 82 0.0120498811068797 130 3344074 SGTC_2897 9048598 12.99 µM 2.25136495313696 0.00965608916980524 no 83 0.0121812159888847 128 6467404 SGTC_3263 9137018 49.47 µM 2.24853376784942 0.00973053878896653 no 84 0.0122710871852366 157 43844957 SGTC_1349 flufenamic acid 69 µM 2.24754493135995 0.00975665941321815 no 85 0.0123026112168101 144 3371 A non-steroidal anti-inflammatory. SGTC_1884 5633444 25 µM 2.24205792728572 0.00990271728363588 no 86 0.0124788143481372 200 5724239 SGTC_2116 5511452 16.8835 µM 2.22611963156615 0.0103378561039532 no 87 0.0130030846535706 159 870744 SGTC_3300 9124615 50.48 µM 2.22072821959815 0.0104887765928504 no 88 0.0131846874485466 184 24824903 SGTC_1549 4'-methoxyflavonol 74.6 µM 2.20935573008486 0.01081343240066 no 89 0.013574953839617 136 97141 SGTC_847 0342-0274 5.54 µM 2.20837024864618 0.010841972929348 no 90 0.0136092369924641 147 18097 SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM 2.20496534973496 0.0109410874192861 no 91 0.0137282630544878 177 5024745 SGTC_3150 9097574 49.47 µM 2.19434331368307 0.0112553714026687 no 92 0.0141053689045517 119 17217476 SGTC_1809 st050081 57.6 µM 2.15922204182417 0.0123510561648696 no 93 0.0154164724104737 171 5036894 SGTC_141 0443-0274 32.331 µM 2.15423270419625 0.0125139733146024 no 94 0.0156109636679799 298 1627241 SGTC_2449 5812982 45.77 µM 2.15287446173293 0.0125586450109605 no 95 0.0156642730354516 132 776185 SGTC_637 1181-0519 7.26 µM 2.14419787611711 0.0128472827731109 no 96 0.0160085175983646 297 6252091 YGR060W ERG25 SGTC_1540 guanosine 70.6 µM 2.14144191682584 0.0129401560232241 no 97 0.0161192088612099 138 6802 Guanosine is a purine nucleoside SGTC_358 0075-0058 9.45 µM 2.13284205893423 0.0132337049018719 no 98 0.0164688423669893 280 1069125 SGTC_1283 0922-0125 16.4 µM 2.13264177024678 0.0132406095879943 no 99 0.016477062013451 175 3360884 SGTC_2957 9076800 11.52 µM 2.12074880682356 0.0136562215818782 no 100 0.016971473430317 179 16459615 SGTC_555 4296-0685 37 µM 2.11320564681986 0.0139256191636224 no 101 0.0172915851002064 174 2908540 YHR072W ERG7 SGTC_1197 1601-0112 267 µM 2.08907802683057 0.0148183029888965 no 102 0.0183503499835894 222 7350313 SGTC_1300 1094-0077 113 µM 2.0889359873286 0.0148237006384939 no 103 0.0183567429061825 176 5532636 SGTC_827 3253-0474 693 µM 2.07302626860951 0.0154390854097385 no 104 0.0190849174704959 204 5402065 SGTC_1065 prochlorperazine maleate 2.48 µM 2.05687801530127 0.0160859967413406 no 105 0.0198489806066712 212 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine. SGTC_760 0568-0725 82.9 µM 2.05636400400434 0.0161069642748801 no 106 0.0198737216059499 167 3916171 SGTC_2560 caryophyllene 100 µM 2.05373415443939 0.0162146078352432 no 107 0.0200007144781563 224 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor. SGTC_1097 itavastatin 7.23 µM 2.0434449441791 0.0166417025686585 no 108 0.0205042061012921 222 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49 SGTC_1787 fluconazole 80 µM 2.03911316535419 0.0168243693042198 no 109 0.0207193672774331 296 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C SGTC_2113 5491891 107.031 µM 2.03060776296133 0.0171880264277195 no 110 0.0211473998065773 237 789979 SGTC_397 arbidol 50 µM 2.0273057682399 0.0173310055353236 no 111 0.0213155759882328 219 131410 A RNA synthesis inhibitor. SGTC_2806 7952793 58.44 µM 2.02698567500346 0.0173449196957004 no 112 0.0213319388445748 214 2972490 SGTC_3170 9103054 49.47 µM 2.02256292900506 0.0175381511894174 no 113 0.0215591147326732 188 16432970 SGTC_221 trifluoperazine 10.304 µM 2.01494191717364 0.017875428285844 no 114 0.0219553676400475 440 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1 SGTC_1250 0485-0349 40.2 µM 2.01325814754357 0.0179506871759999 no 115 0.0220437394249949 226 6842794 YDL195W SEC31 SGTC_754 3474-0146 171 µM 2.01267614534173 0.0179767634960528 no 116 0.0220743552604759 229 24762078 SGTC_2992 9074591 71.4286 µM 2.01084961874253 0.0180588099623651 no 117 0.0221706716361286 177 17741321 SGTC_153 4077-0274 519.67 µM 2.00777190517042 0.0181977811430225 no 118 0.0223337678099225 190 3121976 SGTC_1986 st071812 45 µM 2.0074166878489 0.0182138791487367 no 119 0.0223526566982221 156 11838594 SGTC_1546 5-methoxyflavanone 78.7 µM 2.00319560778248 0.0184061039722401 no 120 0.0225781484657677 199 147795 SGTC_3206 9114350 49.47 µM 2.00155626218578 0.018481223016492 no 121 0.0226662385104248 204 17087243 SGTC_1674 st016616 23.6 µM 1.99519220189568 0.0187753195556578 no 122 0.0230109606141012 247 625830 SGTC_213 1246-0773 967 nM 1.99385928410105 0.0188374183165241 no 123 0.0230837173045208 227 6251622 SGTC_785 1270-0111 65.3 µM 1.99038029107955 0.0190003235228063 no 124 0.0232745296592288 256 6741994 SGTC_1563 conessine 56.1 µM 1.98400061189282 0.0193021683645729 no 125 0.0236278858592294 263 441082 An anti-amoebic, histamine inhibitor. SGTC_1071 trifluoperazine 6.31 µM 1.97708147120157 0.0196341338634182 no 126 0.0240162109110367 232 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. SGTC_2854 9024559 71.43 µM 1.97118015955553 0.0199210846897213 no 127 0.0243516362351486 249 3163529 SGTC_277 nystatin 15.5 µM 1.96658821186 0.0201468223704352 no 128 0.0246153517886076 243 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_1503 4585-0012 61.3 µM 1.96562374159711 0.0201945098650126 no 129 0.0246710447750432 203 2922052 SGTC_1452 4194-0072 190 µM 1.9617492123079 0.0203870486997279 no 130 0.0248958446190347 246 1343545 SGTC_281 1672-3440 14.9 µM 1.95361034190934 0.0207965681438998 no 131 0.0253736583189867 205 6833000 SGTC_2304 7443016 91.4 µM 1.95049256555972 0.0209552783036998 no 132 0.0255587193160056 189 939854 SGTC_3047 9092122 49.47 µM 1.93793735324458 0.0216048152963226 no 133 0.0263154330350562 233 17173831 SGTC_128 0906-2981 13.371 µM 1.92909807157196 0.0220722478617168 no 134 0.0268593441835144 193 6740226 SGTC_2152 5568786 200 µM 1.92895499310458 0.0220798836938804 no 135 0.0268682249066737 222 5399883 SGTC_1021 4476-0760 85.3 µM 1.92845341584776 0.0221066695520896 no 136 0.026899376618193 255 746768 SGTC_2045 5106652 78.05 µM 1.92465119601662 0.0223106137775405 no 137 0.0271365049662853 203 673349 SGTC_877 0771-0151 33.1 µM 1.91927532812679 0.0226016724879264 no 138 0.0274747493382405 243 6166523 SGTC_2611 pyromycin 23.93 µM 1.91288532806319 0.0229517955170053 no 139 0.0278813671297972 271 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release. SGTC_1670 st016595 4.04 µM 1.90898522029896 0.0231677284389636 no 140 0.028131999147861 240 597879 SGTC_586 0957-0265 8.15 µM 1.90682879403814 0.0232878534415687 no 141 0.0282713806824313 186 6752309 YPR165W | YPR107C RHO1 | YTH1 SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM 1.9056237777311 0.0233552076156474 no 142 0.0283495174466157 287 23847180 SGTC_1026 k007-1105 30.6 µM 1.90399996407229 0.0234462296315452 no 143 0.0284550944309165 352 7066794 SGTC_1859 st055998 20 µM 1.9011909744189 0.0236043907741685 no 144 0.028638501428168 250 676301 SGTC_2005 4024620 188 µM 1.89128344546591 0.0241694194744149 no 145 0.0292932586755775 232 236743 SGTC_1856 st057054 55.7 µM 1.883853152281 0.0246005883625293 no 146 0.0297924207879815 254 1266018 SGTC_1133 3473-0247 50 µM 1.88256016746843 0.0246762737969033 no 147 0.0298799993826599 315 711311 SGTC_2608 thymoquinone 42.66 µM 1.88215253550517 0.0247001751792232 no 148 0.0299076540214999 224 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC). SGTC_2442 5158906 48.48 µM 1.88099678662994 0.0247680478028474 no 149 0.0299861779810383 260 1893835 SGTC_2733 amorolfine 100 µM 1.88016814959632 0.0248168066580584 no 150 0.0300425824590396 119 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_1909 st060837 51.5 µM 1.87711767766458 0.0249969974893081 no 151 0.0302509835278152 279 678937 SGTC_1822 st052468 42 µM 1.87478081324863 0.0251357765278598 no 152 0.0304114419040466 218 2873678 SGTC_1960 st011366 51.8 µM 1.87350878988599 0.0252115890333575 no 153 0.0304990800516563 202 3972846 SGTC_469 w7 172 µM 1.86431553371132 0.0257652224294551 no 154 0.031138703333375 161 45115570 A P450 inhibitor. SGTC_1257 0669-0121 16 µM 1.8569053449889 0.0262188499329401 no 155 0.0316623110033602 305 4307855 SGTC_2874 9043904 71.43 µM 1.85173305581825 0.0265394220309552 no 156 0.0320320824065909 203 4463428 SGTC_2317 5986382 200 µM 1.84724452201893 0.02682026364209 no 157 0.0323558547056331 241 877883 SGTC_2948 9070189 9.45 µM 1.84438590421911 0.0270004137355168 no 158 0.0325634600482451 259 6473636 YDL196W YDL196W SGTC_2900 5328528 85.29 µM 1.83843525736346 0.0273786640986524 no 159 0.0329991468926727 315 795359 SGTC_209 4077-0173 175.592 µM 1.83228548380171 0.0277742048689831 no 160 0.0334544493298064 176 15993494 SGTC_2818 7996756 12.99 µM 1.83091536458695 0.0278629736724129 no 161 0.0335565883294436 181 2241621 SGTC_665 3914-0008 307 µM 1.82731816173981 0.0280971586819321 no 162 0.0338259730377627 279 1069549 SGTC_2267 7931562 200 µM 1.82572735210784 0.0282012449546678 no 163 0.0339456704975044 247 934880 SGTC_215 1287-0124 461.5 µM 1.82414812678899 0.0283048905582095 no 164 0.0340648406749102 175 5560863 SGTC_667 1498-1044 59 µM 1.81462584373396 0.0289365840562987 no 165 0.0347907140676135 276 6739982 SGTC_3171 9103192 49.47 µM 1.81233006673768 0.0290906229538945 no 166 0.0349676057264173 212 13018434 SGTC_618 k072-0232 33.2 µM 1.81184973279171 0.0291229377779872 no 167 0.0350047091100728 251 5872756 YGL099W LSG1 SGTC_82 0054-0107 293.755 µM 1.81030678329431 0.0292269426786441 no 168 0.0351241128575387 232 3104697 SGTC_2124 5246320 200 µM 1.80583161499767 0.0295303446928543 no 169 0.0354723227662992 282 579342 SGTC_1226 3909-7979 35.4 µM 1.79432935628235 0.0303221737872192 no 170 0.0363803075715422 337 6615510 SGTC_508 roscovitine 141 µM 1.79015371876522 0.0306139484345831 no 171 0.0367146014674148 226 160355 A CDKinase inhibitor. SGTC_2111 5486399 200 µM 1.78555618362095 0.0309378888996069 no 172 0.037085573374887 340 689674 SGTC_484 loperamide 105 µM 1.77170492082534 0.0319310314665198 no 173 0.0382217761985302 158 3955 An opioid-receptor agonist. SGTC_2971 9092186 9.93 µM 1.77036017221897 0.0320288373394245 no 174 0.0383335800323786 271 25236400 SGTC_2224 6650123 117.647 µM 1.77032784073942 0.0320311919052658 no 175 0.038336271384921 233 2908370 SGTC_2105 5350118 200 µM 1.76183497157228 0.03265466025623 no 176 0.0390485920893387 289 2133313 SGTC_1224 0823-0416 294 µM 1.75854592369688 0.0328987849378638 no 177 0.0393273324130158 284 3598164 SGTC_2319 6033012 152.6 µM 1.75717411198862 0.0330010492159426 no 178 0.0394440682139217 250 847246 SGTC_1328 1441-0025 69.2 µM 1.75037484867817 0.0335117869400157 no 179 0.040026826530925 258 4562601 SGTC_2161 5662504 8.5105 µM 1.74935013966031 0.033589320897972 no 180 0.0401152569616182 285 2859334 SGTC_861 0443-0273 110 µM 1.74819557502467 0.0336768571350186 no 181 0.0402150837872279 270 6149169 SGTC_351 caspofungin 25 nM 1.74359346103161 0.0340276454850436 no 182 0.0406150021690384 452 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1 SGTC_1902 st060212 70.5 µM 1.7425470843533 0.0341078216219839 no 183 0.0407063800334015 306 688944 SGTC_2653 dihydrofissinolide 100 µM 1.73935851332738 0.0343530966169211 no 184 0.0409858604276701 235 6857746 SGTC_3331 9141060 1.957 µM 1.73814626021016 0.0344467264570038 no 185 0.0410925227146647 300 4906567 YPR165W RHO1 SGTC_1070 indatraline 8.81 µM 1.73286618773758 0.0348569878313376 no 186 0.0415597276428122 332 10314472 A monamine transport inhibitor. YGL099W LSG1 SGTC_1865 st057639 52.2 µM 1.72608057023086 0.0353901113596003 no 187 0.0421664594020566 305 688818 SGTC_2019 4016004 108 µM 1.7259818472778 0.0353979167711714 no 188 0.0421753392734488 275 45595336 SGTC_2012 4023501 200 µM 1.72403255859237 0.0355523242848538 no 189 0.042350982824418 302 3477460 SGTC_2510 benzyl isothiocyanate 8.31 µM 1.72337413970929 0.0356046037024492 no 190 0.0424104441561047 299 2346 DNA damaging agent; causes G2/M arrest. SGTC_309 k408-0051 1.48 µM 1.72197181598798 0.0357161602940506 no 191 0.0425373120671001 404 3640463 SGTC_1548 st061468 90.8 µM 1.72106370815596 0.0357885540917132 no 192 0.0426196319740334 283 390799 SGTC_3109 9122853 49.47 µM 1.71402430779266 0.0363538183337583 no 193 0.0432621308408629 296 1234709 SGTC_2775 cyproheptadine 69.59 µM 1.71222058113389 0.0364998278666756 no 194 0.043428012998719 294 2913 A selective serotonin reuptake inhibitor. SGTC_1353 1498-1206 8.11 µM 1.70829330442855 0.0368193962909009 no 195 0.0437909665300014 383 6756808 SGTC_2228 7354201 200 µM 1.70239042942804 0.0373040226536924 no 196 0.0443411014707984 262 753451 SGTC_750 4073-0104 132 µM 1.70083806364258 0.0374323337623659 no 197 0.0444866997758549 250 22330957 SGTC_2195 6536160 144.242 µM 1.70042740431602 0.0374663371156374 no 198 0.04452528037795 285 3834386 SGTC_219 mitoxanthrone 164.414 µM 1.69797381687688 0.0376700246715413 no 199 0.044756351852454 345 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA.  YMR168C CEP3 SGTC_2314 7727897 200 µM 1.69668232140963 0.0377776023584847 no 200 0.0448783683685261 316 900724 SGTC_2934 9036370 36.88 µM 1.69658544847878 0.0377856816813001 no 201 0.0448875314115036 372 6462800 SGTC_2098 5376439 882.5 nM 1.69539124374554 0.0378853957358747 no 202 0.0450006129446553 339 2844116 SGTC_1236 0330-0013 258 µM 1.69460196722421 0.037951416754734 no 203 0.0450754768222574 284 4617066 SGTC_2274 7947094 46.08 µM 1.69352799771275 0.0380414023691313 no 204 0.0451775051360602 345 2971028 SGTC_311 1315-0136 58 µM 1.6933424886955 0.0380569633884875 no 205 0.045195147507897 305 6759207 SGTC_3063 1327-0034 4 µM 1.68683020105183 0.0386065312628607 no 206 0.0458180032252572 321 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_482 fipronil 114 µM 1.68380764945295 0.0388637907651098 no 207 0.0461094242031946 217 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels. SGTC_2480 5767542 37.17 µM 1.6833044952934 0.0389067511502483 no 208 0.046158080321631 308 2867358 SGTC_1720 st037298 9.481 µM 1.6810210624407 0.0391022018159993 no 209 0.0463794117565852 334 597396 SGTC_560 2332-1943 155 µM 1.67923051274083 0.0392560225819794 no 210 0.0465535637295445 302 21177716 SGTC_920 mycophenolic acid 780.421 nM 1.67285155758369 0.039808026145359 no 211 0.0471782611172095 350 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_2521 angolensin 13.4 µM 1.67143769371756 0.0399312253678005 no 212 0.0473176279243924 297 821428 A flavenoid. SGTC_23 0213-0011 39.996 µM 1.66745687333131 0.0402797655943978 no 213 0.047711796523691 319 627608 SGTC_1264 0783-0040 158 µM 1.65955537569799 0.0409788992060416 no 214 0.0485019659177104 318 2855798 SGTC_2748 diazoxide 86.69 µM 1.6566814302253 0.0412356174317461 no 215 0.0487919496551324 268 3019 A potassium channel activatior. SGTC_2031 5180455 200 µM 1.65407902487745 0.0414692034252391 no 216 0.0490557286308045 293 29949 SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM 1.65144748724945 0.0417064933896161 no 217 0.0493236175408726 419 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_1839 st053978 48 µM 1.64222067205108 0.0425471909919031 no 218 0.050272140045797 338 3788398 SGTC_1387 3342-1166 1.8 µM 1.64183502806284 0.0425826249814291 no 219 0.0503120988241165 238 3418228 SGTC_2323 6148992 148.28 µM 1.63761192292084 0.0429722185014187 no 220 0.0507513371440267 307 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42 SGTC_2917 7979103 53.79 µM 1.63218886013194 0.0434767298899607 no 221 0.0513198533939768 413 2980565 SGTC_510 ag-490 170 µM 1.63205168584044 0.0434895530472825 no 222 0.0513342992196688 320 5328779 SGTC_2226 7298446 200 µM 1.61529387708195 0.0450791972490648 no 223 0.0531235344920384 304 3283010 SGTC_1438 4092-1045 4 µM 1.61391336701208 0.0452122104785009 no 224 0.0532731094251293 340 1351342 SGTC_521 r062-0005 13.8 µM 1.61200083706648 0.0453970058051099 no 225 0.0534808787870967 351 2832033 SGTC_1898 st060199 18.6 µM 1.60995263811294 0.0455955830972333 no 226 0.0537040981209221 327 688866 SGTC_1025 k007-0731 70 µM 1.60941638042802 0.0456476896277891 no 227 0.0537626629410477 360 6256118 SGTC_2961 9083290 32.55 µM 1.60681735349277 0.0459009077803716 no 228 0.0540472201680062 322 17741490 SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM 1.60540345973416 0.0460391340032206 no 229 0.0542025217609858 404 5379071 SGTC_796 1234-0020 70.7 µM 1.59841085021137 0.0467276746258033 no 230 0.0549757857315807 380 46495034 SGTC_2123 5259487 200 µM 1.59758835358522 0.0468092035283588 no 231 0.0550673100331047 372 2173474 SGTC_1965 Pectolinarigenin 58.4 µM 1.59463795968925 0.047102596653969 no 232 0.0553966094399712 350 5320438 An anti-inflammatory. SGTC_2877 9040724 71.43 µM 1.59125983052606 0.0474403330950537 no 233 0.0557755564726555 340 6463895 SGTC_2913 7966556 36.57 µM 1.5856609908344 0.0480043603948995 no 234 0.0564081163446972 338 2976516 SGTC_857 0438-0306 1.35 µM 1.58491354101139 0.0480800629373453 no 235 0.0564929897520318 373 4686136 SGTC_713 1488-1073 324 µM 1.57919224009176 0.0486626916697019 no 236 0.0571459846619513 339 3312542 SGTC_2819 7996655 46.38 µM 1.57785149278414 0.0488000397149692 no 237 0.0572998654758208 333 6456960 SGTC_40 0327-0103 19.753 µM 1.57363839999428 0.0492336521730786 no 238 0.0577855351849134 374 409036 SGTC_831 k061-1017 217 µM 1.57233947245446 0.0493679568529889 no 239 0.0579359216940043 551 1240153 SGTC_883 0850-0245 24.6 µM 1.57209199867544 0.0493935779392557 no 240 0.057964608432539 419 6823229 YPR165W RHO1 SGTC_2810 7959871 45.46 µM 1.55918539214128 0.0507445829045055 no 241 0.05947625362904 459 2974535 SGTC_2727 riluzole 51.77 µM 1.55577260870135 0.0511066934910024 no 242 0.0598810868716562 340 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.  SGTC_12 0849-0099 9.267 µM 1.55427592180799 0.0512661455113656 no 243 0.0600593071979194 378 6071388 SGTC_1017 4239-0030 168 µM 1.55137629676888 0.0515761878556736 no 244 0.0604057661021586 433 1149593 SGTC_2486 5283202 22.39 µM 1.55134068205439 0.0515800052060091 no 245 0.0604100311942213 405 1377751 SGTC_2185 6113692 200 µM 1.55037257121572 0.0516838578941099 no 246 0.0605260590115558 364 874150 SGTC_756 0508-1999 28.3 µM 1.55028649560088 0.0516930995719535 no 247 0.060536383584621 386 6753853 SGTC_2623 humulene 100 µM 1.54657279966322 0.0520930803594289 no 248 0.0609831464504892 336 6187145 An anti-inflammatory. SGTC_698 k064-0052 127 µM 1.54654403852463 0.0520961876223417 no 249 0.0609866164870028 313 5088751 SGTC_721 1187-1332 279 µM 1.54388573768836 0.0523840183143966 no 250 0.0613080079093303 286 25730 SGTC_850 0388-0143 75.9 µM 1.53634943645227 0.0532068874047466 no 251 0.0622263504058377 384 67273 SGTC_3247 9135149 49.47 µM 1.53581686777158 0.0532654226769076 no 252 0.0622916507707724 334 8934436 YOR116C RPO31 SGTC_2468 5987765 72.9 µM 1.53331192731942 0.0535414287171193 no 253 0.0625995086106434 404 26772094 SGTC_122 0236-0016 402.397 µM 1.53116697584705 0.0537786689484488 no 254 0.0628640651701939 478 6808838 SGTC_509 pifithrin 175 µM 1.53092310652342 0.053805694495882 no 255 0.062894198881862 337 4817 A p53 inhibitor. SGTC_63 0099-0242 26.702 µM 1.52864922119508 0.0540582039446013 no 256 0.0631757134358267 474 3898502 YLR359W ADE13 SGTC_2104 5389443 200 µM 1.52807718134863 0.054121875018007 no 257 0.063246688109039 450 2244536 SGTC_597 k018-0003 82.8 µM 1.52484535576167 0.054482709964256 no 258 0.0636488370408682 414 6786234 SGTC_1109 tnp00067 928.257 nM 1.51621595908125 0.0554555131455755 no 259 0.0647323769671236 390 676295 SGTC_2359 9039622 200 µM 1.51340404477275 0.0557754496511173 no 260 0.0650885291079075 412 6463596 SGTC_2604 4'-hydroxychalcone 11.32 µM 1.50619365103191 0.056602497364399 no 261 0.0660087344076819 396 5282362 SGTC_2747 doxorubicin 7.63 µM 1.50518221634884 0.0567192799063041 no 262 0.0661386179894243 245 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_227 fluconazole 33.516 µM 1.50199149946529 0.0570889314396145 no 263 0.0665496520900261 493 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C SGTC_387 norethindrone acetate 66.7 µM 1.4988792584689 0.0574513158553461 no 264 0.0669524790668604 379 541197 SGTC_2018 5133068 143 µM 1.49364634778011 0.0580647042972074 no 265 0.067634039300759 429 785362 SGTC_783 0848-0141 92.7 µM 1.48877439948092 0.0586403966675515 no 266 0.0682733929131453 402 6755076 YHR007C | YLR033W ERG11 | RSC58 SGTC_2669 eugenol 100 µM 1.48747758746554 0.0587943867067204 no 267 0.0684443591858586 339 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism. SGTC_300 r073-0011 5.04 µM 1.48159532980482 0.0594968638017336 no 268 0.0692240012147215 492 2735780 SGTC_1774 st048371 48.465 µM 1.47900624277314 0.0598081380374297 no 269 0.0695693231700488 458 4242727 SGTC_148 3253-0744 288.01 µM 1.47744623611883 0.0599963056109606 no 270 0.0697780300011657 403 6893655 SGTC_638 3970-0837 4.09 µM 1.47084989613222 0.0607970834986185 no 271 0.070665857583328 437 4118451 YLR208W SEC13 SGTC_3151 9099821 49.47 µM 1.46505102449353 0.0615079326641158 no 272 0.0714534986134251 390 17174189 SGTC_2227 7312221 64.1025 µM 1.46287777222754 0.061776004863535 no 273 0.0717504136057084 375 887188 YOR168W | YOR169C GLN4 | YOR169C SGTC_2772 vinpocetine 57.06 µM 1.45843133478015 0.062327317268262 no 274 0.0723608444555953 436 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor. SGTC_2001 4023502 57.655 µM 1.45700410146857 0.0625050906454911 no 275 0.0725576240301638 464 108941 YCR052W RSC6 SGTC_781 4335-2806 94.4 µM 1.45691764212005 0.0625158725380993 no 276 0.0725695577539104 497 845254 SGTC_260 nsc-65238 3.989 µM 1.45510369470313 0.0627424149075924 no 277 0.0728202782431562 429 3246252 SGTC_3029 9088683 49.47 µM 1.45390588273341 0.0628923589996086 no 278 0.0729862008168718 429 25236615 SGTC_1998 st075797 76.8 µM 1.45352426013846 0.0629401897476304 no 279 0.0730391244435385 481 24208315 SGTC_1121 fusaric acid 630.51 nM 1.45235731947365 0.0630866243239267 no 280 0.0732011386211101 467 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler. SGTC_647 0140-0236 81 µM 1.45117883142856 0.0632347770847233 no 281 0.0733650349089558 506 990837 SGTC_1376 2910-0861 41.3 µM 1.45111997331697 0.0632421834857629 no 282 0.0733732278573473 471 1112859 SGTC_3231 9132313 49.47 µM 1.44262422496238 0.0643183470101318 no 283 0.0745631777084881 449 4905967 SGTC_2699 st077704 54.6 µM 1.44032510083878 0.0646120121005802 no 284 0.074887721544816 458 645852 SGTC_720 r052-1644 49.9 µM 1.4392316879422 0.0647520376817334 no 285 0.0750424450658792 401 1422863 YOR257W CDC31 SGTC_1423 4048-0112 5.59 µM 1.43865420865049 0.0648260863631805 no 286 0.0751242596616984 458 X1423 SGTC_2657 nystatin 74.44 µM 1.43724259804916 0.0650073703390197 no 287 0.0753245364501457 471 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_2376 9072922 81.32 µM 1.43671959385259 0.0650746361827066 no 288 0.0753988425935394 496 17087968 SGTC_1887 st057648 70.8 µM 1.43536235368351 0.0652494487261334 no 289 0.0755919339330473 454 688672 SGTC_1953 st076800 12.1 µM 1.42827288436068 0.0661685006175934 no 290 0.0766066646845894 499 297591 SGTC_476 mead acid 10 µM 1.42497061621864 0.0666000027451829 no 291 0.0770828475517284 379 5312531 An omega 9 fatty acid. SGTC_1833 st055984 71 µM 1.41249852526455 0.0682493797530128 no 292 0.0789016123062971 444 676288 SGTC_2516 gossypol 71.55 µM 1.41105752251927 0.0684419597955207 no 293 0.0791138267858952 496 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_1167 k781-0610 148 µM 1.4109682080393 0.0684539098411755 no 294 0.0791269942169792 513 4525169 SGTC_2618 avocadyne 43.43 µM 1.40741716746748 0.0689303353254127 no 295 0.0796518617577635 438 3015189 SGTC_642 0335-0876 158 µM 1.40512608180973 0.0692390728140876 no 296 0.0799918948047947 486 6812350 SGTC_2732 terfenadine 20 µM 1.40286855607918 0.0695443288933711 no 297 0.0803280194705769 398 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.  SGTC_1512 0259-0544 12.2 µM 1.3997456360799 0.0699683080240921 no 298 0.0807947512805334 517 18476 SGTC_455 paf C-16 10 µM 1.39739467158351 0.0702887936923942 no 299 0.0811474602953252 449 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis. SGTC_2054 5233173 129 µM 1.39589000779893 0.0704945025598557 no 300 0.081373810051627 539 6889 SGTC_3168 9103419 49.47 µM 1.39235727055794 0.0709792964498874 no 301 0.0819071184517123 352 16649256 SGTC_1487 3970-0795 2.82 µM 1.39210690054019 0.0710137514024099 no 302 0.0819450144785532 494 3765103 SGTC_2259 7964009 200 µM 1.38430168367934 0.0720943295905283 no 303 0.0831330493579623 447 313134 SGTC_2556 citropten 84.59 µM 1.3839759678755 0.072139695156278 no 304 0.083182906739486 543 2775 A potential DNA crosslinker. SGTC_1442 4112-3290 3 µM 1.38170337786639 0.0724568297439125 no 305 0.0835313984054543 506 704353 SGTC_1456 k015-0012 13 µM 1.37928897337543 0.0727949231663663 no 306 0.083902837456694 561 2989616 SGTC_1215 3852-0577 11.2 µM 1.37622393452504 0.0732258644644054 no 307 0.08437615709056 548 2884876 SGTC_2679 rapamycin 1 nM 1.37206531480396 0.0738136792631158 no 308 0.0850215529618781 613 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2 SGTC_1467 k284-1082 293 µM 1.36979858624237 0.0741355930061055 no 309 0.0853748917573841 517 3334705 SGTC_1838 st055369 84.5 µM 1.3686824985653 0.0742944897914213 no 310 0.0855492716803534 445 676036 SGTC_2528 xanthyletin 44.79 µM 1.36750069326035 0.0744630261136126 no 311 0.0857342100583882 467 65188 An natural product with antifungal activity of unknown mechanism. SGTC_499 genistein 192 µM 1.3655190964356 0.0747462748542407 no 312 0.0860449776186721 426 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger. SGTC_1945 st075991 56.6 µM 1.36521704802937 0.0747895216581058 no 313 0.086092420845609 482 1084980 SGTC_1520 flindersine 88 µM 1.36477681044368 0.0748525883531975 no 314 0.0861616047136061 519 68230 Flindersine is a natural alkaloid of the quinoline subtype. SGTC_3163 9099914 49.47 µM 1.36439312522002 0.0749075866625704 no 315 0.086221935220306 418 16268368 SGTC_1112 tnp00069 1.16933 µM 1.36366341780355 0.0750122696315586 no 316 0.0863367612936248 561 145826 SGTC_1683 st010134 710 nM 1.35955166708382 0.0756042233251008 no 317 0.0869859209572047 506 3818134 SGTC_640 3381-0960 37.1 µM 1.3573152263032 0.0759276864116702 no 318 0.08734053566586 525 1745025 SGTC_675 1309-0189 238 µM 1.35464884256368 0.0763147093218014 no 319 0.0877647320444562 499 4246530 SGTC_2131 toluylene red 5.2905 µM 1.35403266651505 0.076404359824485 no 320 0.0878629780659491 511 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain. SGTC_983 1491-0821 12.2 µM 1.35188646923758 0.0767172463565111 no 321 0.088205818343978 470 46495113 SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM 1.35148286479458 0.0767761951158316 no 322 0.0882704026247662 562 4174840 SGTC_2884 9058502 51.95 µM 1.34977498819681 0.0770260216210784 no 323 0.0885440850605138 521 6471554 SGTC_942 3253-1115 227 µM 1.34304872091117 0.0780159442521259 no 324 0.0896280991598578 529 46497897 SGTC_706 4262-0057 46.9 µM 1.33812719188092 0.0787463523537276 no 325 0.0904274890317974 517 883298 SGTC_842 0271-0008 11.1 µM 1.33739041814133 0.0788561420116599 no 326 0.09054761525111 565 1221709 SGTC_2715 st079500 56.4 µM 1.33595625598747 0.0790701848696784 no 327 0.0907817858306027 472 28246688 SGTC_2092 5303694 80.6725 µM 1.33458552586122 0.0792751717102077 no 328 0.0910060189377712 552 1963699 SGTC_2644 guaiazulene 100 µM 1.33303904733989 0.0795069236815237 no 329 0.0912594950634831 493 3515 A coloring agent. SGTC_1339 1486-1321 22.7 µM 1.33279530170552 0.0795434976064404 no 330 0.0912994939881765 533 3469382 SGTC_2537 larixol 68.93 µM 1.33134099276741 0.0797619806510081 no 331 0.0915384178355094 575 6708759 SGTC_1857 st056007 79.3 µM 1.32520806196855 0.0806883357018876 no 332 0.0925510760791173 487 619834 SGTC_384 k007-0144 5.16 µM 1.32511802570067 0.0807019955848884 no 333 0.0925660041812569 586 6824886 SGTC_3184 9108758 49.47 µM 1.3249878569892 0.0807217472625558 no 334 0.0925875894311965 502 902885 SGTC_2146 5545642 200 µM 1.3239251130056 0.0808831436229566 no 335 0.0927639584535697 527 825326 SGTC_1348 1493-0373 93.8 µM 1.32236415721686 0.0811206437370498 no 336 0.0930234591218906 514 3010129 SGTC_531 3788-1495 174 µM 1.31954589520994 0.0815507757796163 no 337 0.0934933386257246 518 2896655 SGTC_1412 3909-8563 178 µM 1.31803267628302 0.0817824365086034 no 338 0.0937463547825802 585 23767530 SGTC_1792 st045773 43.6 µM 1.31490405530792 0.0822629737560767 no 339 0.0942710748366996 521 2919270 SGTC_1853 st056710 91.2 µM 1.31415307182871 0.0823786361236446 no 340 0.0943973486240189 554 269167 SGTC_1852 st056254 31.4 µM 1.31392721954103 0.0824134445969903 no 341 0.0944353488424291 522 442583 SGTC_1073 triclabendazole 3.09 µM 1.31174125676177 0.0827509188158472 no 342 0.0948037256633418 606 50248 An antihelmetic and likely tubulin inhibitor. SGTC_1637 st007924 17.4 µM 1.31139503782608 0.0828044641885075 no 343 0.0948621672247681 538 683336 SGTC_1028 k015-0029 4.8 µM 1.31038780330462 0.0829603888536078 no 344 0.0950323387832509 573 4588309 SGTC_1572 epiandrosterone 68.9 µM 1.31037121452456 0.0829629587226018 no 345 0.0950351433268188 574 441302 A steroid. SGTC_625 k213-0058 121 µM 1.30777845445948 0.0833653554841434 no 346 0.0954742320321926 736 3655420 SGTC_2404 5161160 200 µM 1.30721693561047 0.0834526962491514 no 347 0.0955695226834211 560 2831543 SGTC_747 3448-8087 38.7 µM 1.30673744451787 0.0835273325287947 no 348 0.0956509484775184 558 5168703 SGTC_1618 st003135 44.5 µM 1.30671155723847 0.0835313634990566 no 349 0.0956553460325489 524 1270615 SGTC_3038 9091290 49.47 µM 1.30445447325995 0.0838833817356879 no 350 0.0960393362572084 552 25236843 SGTC_591 4299-0174 154 µM 1.29976216613297 0.0846187648555808 no 351 0.0968412481415565 541 5509088 SGTC_2682 pyrogallin 40.03 µM 1.29317911336718 0.0856586038369685 no 352 0.0979745588960152 598 822798 An ATP competetive kinase inhibitor. SGTC_1600 coumarin 106 71.1 µM 1.2893355305429 0.0862701318043708 no 353 0.0986407318846875 582 100336 A hepatotoxic, DNA x-linker. SGTC_1036 k216-0215 33.5 µM 1.28782224311441 0.0865117951240148 no 354 0.0989039237848002 593 622330 SGTC_3196 9111891 49.47 µM 1.28650357671085 0.0867227909150876 no 355 0.0991336856814188 517 18891510 SGTC_1905 st060207 84.5 µM 1.28648051494496 0.0867264843765282 no 356 0.0991377073893258 559 1948547 SGTC_1187 1391-0724 117 µM 1.28477144555502 0.0870005279784211 no 357 0.0994360816929156 585 6997986 SGTC_1643 st009866 20.2 µM 1.28383216770935 0.0871514132214504 no 358 0.0996003427963882 521 3156273 YOR207C RET1 SGTC_800 3448-7362 155 µM 1.28224376951663 0.0874070174270097 no 359 0.0998785732337573 830 15991913 SGTC_2427 5545055 42.75 µM 1.28183178764818 0.0874734046316004 no 360 0.0999508303183092 608 5372858 SGTC_329 k048-0121 21.3 µM 1.27988822787893 0.0877870995540664 no 361 0.100292224200729 533 6832902 SGTC_1847 st056231 15 µM 1.27974035175765 0.0878110014012451 no 362 0.100318234018259 617 5393180 SGTC_557 1315-0110 16.2 µM 1.27961508413769 0.0878312527374892 no 363 0.100340271095077 558 6833801 SGTC_3113 9123498 49.47 µM 1.27920087821461 0.0878982399640982 no 364 0.100413163345498 545 8897275 SGTC_174 3553-0389 74.3 µM 1.27810582922042 0.0880755196757057 no 365 0.100606056934365 521 738071 SGTC_1337 1486-1011 40.3 µM 1.27790664761652 0.0881077942251436 no 366 0.100641171937753 550 X1337 SGTC_2887 9044784 58.44 µM 1.27732327318303 0.0882023724935374 no 367 0.100744070195936 576 6465546 SGTC_2503 beta-caryophyllene alcohol 24.72 µM 1.27535991611676 0.0885212332720213 no 368 0.101090939724443 487 61125 An anti-inflammatory. SGTC_479 n-linoleoylglycine 10 µM 1.26751710181939 0.0898035217119198 no 369 0.102485226262748 523 6433346 An anti-infammatory. SGTC_251 melphalan 456.522 µM 1.26718443646405 0.0898582156578578 no 370 0.102544674711492 642 460612 A DNA alkylator. SGTC_1832 st054113 55 µM 1.26650797643199 0.0899695096892498 no 371 0.102665637768903 526 1251267 SGTC_1635 st007035 42.4 µM 1.26390511969209 0.0903986979661303 no 372 0.103132041996213 760 3716403 SGTC_1086 cerivastatin 2.18 µM 1.26323710493413 0.0905090925129727 no 373 0.103251990889884 540 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7 SGTC_709 3807-1509 243 µM 1.26168049732949 0.0907667221099661 no 374 0.103531888689284 542 1886677 YPL242C IQG1 SGTC_1526 st051518 75 µM 1.25913464402208 0.0911892511015097 no 375 0.103990851490751 528 673993 SGTC_2568 diosmetin 100 µM 1.25904730261653 0.0912037727731711 no 376 0.104006623409562 596 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.  SGTC_2791 5663188 71.43 µM 1.25786159769337 0.0914010816877745 no 377 0.104220907025993 534 54690634 SGTC_982 1491-0518 27.5 µM 1.25751571517051 0.0914586983308772 no 378 0.104283476046749 521 3091256 SGTC_1470 k295-0292 231 µM 1.25734188682912 0.0914876645831175 no 379 0.104314931304312 603 5045612 SGTC_2236 dapsone 200 µM 1.25685208463808 0.0915693203749313 no 380 0.104403600866397 598 2955 A bacterial DFR inhibitor. An anti-cancer agent. SGTC_603 3794-0023 45.9 µM 1.25087404230083 0.0925702862304258 no 381 0.105490217837799 556 3802260 SGTC_890 0929-0006 47.2 µM 1.24982993576521 0.0927459390356822 no 382 0.105680839045473 554 1378169 SGTC_2916 7875993 68.79 µM 1.24811789683088 0.0930344931283353 no 383 0.10599394257836 580 1299250 SGTC_180 1486-1293 102.781 µM 1.24667240222059 0.0932786389588954 no 384 0.106258821022266 587 4140536 SGTC_1165 k072-0275 30.3 µM 1.24064558450225 0.0943016782781158 no 385 0.107368352216033 567 6153523 YGL055W OLE1 SGTC_312 4092-0653 6.84 µM 1.24029885831251 0.0943607850486333 no 386 0.107432437271541 686 1148278 SGTC_235 0330-0087 5 mM 1.2386707114709 0.0946387023040663 no 387 0.107733734726758 612 46494818 YHR062C RPP1 SGTC_3154 9100113 49.47 µM 1.23740335687471 0.0948554512237513 no 388 0.107968686592217 587 25237525 SGTC_2291 7917025 104.35 µM 1.23668741432331 0.0949780566351594 no 389 0.108101576465311 618 2964612 SGTC_1347 1493-0251 600 nM 1.23510839411466 0.0952488769919373 no 390 0.108395082887177 640 3986378 SGTC_62 0180-0423 3.232 µM 1.23290410580362 0.0956278884139529 no 391 0.108805771721854 571 30102 YGL099W LSG1 SGTC_746 1095-0025 46.6 µM 1.23016699766588 0.096100057410837 no 392 0.109317287759134 628 6749286 SGTC_2051 5263410 176 µM 1.22928762546028 0.0962521180622881 no 393 0.109481992612236 615 227584 SGTC_2546 rhodinyl acetate 100 µM 1.22404838344701 0.0971617525484208 no 394 0.110466988001661 619 6708682 SGTC_261 5-fluorouridine 15.376 µM 1.22065559725387 0.0977541622337121 no 395 0.111108223164493 610 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_2093 5331342 194.4 µM 1.21922691476353 0.0980044132360627 no 396 0.111379039574486 619 33839 SGTC_2039 Aminomethylbenzodioxan 200 µM 1.21779395981553 0.0982558838517064 no 397 0.111651140120859 545 15053 SGTC_1660 st012960 28.1 µM 1.21751673280374 0.0983045891961019 no 398 0.111703836982629 605 24207266 SGTC_2754 granisetron 64.02 µM 1.21641490515127 0.0984983414369957 no 399 0.111913454425987 620 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients. SGTC_689 0833-0039 98 µM 1.21612348303417 0.098549633640689 no 400 0.111968943097474 631 5374726 SGTC_913 3487-1245 167 µM 1.21443222153805 0.0988476928300475 no 401 0.112291358689356 607 4016153 SGTC_2042 p-Dimethylaminoacetophenone 200 µM 1.21423208845229 0.0988830068498888 no 402 0.112329555145886 588 75037 A free radical scavenger. SGTC_2947 9072639 7.68 µM 1.2083461897003 0.0999257209120868 no 403 0.113457064287436 659 16488146 SGTC_2431 5490079 200 µM 1.20767121435362 0.100045807238494 no 404 0.113586877310394 621 5722345 SGTC_2735 sertaconazole 140 nM 1.20315364793662 0.100852250941341 no 405 0.114458434087851 541 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C SGTC_375 3970-0961 9.27 µM 1.20118005099756 0.101206047179518 no 406 0.114840682995203 617 2898222 SGTC_1366 1683-0113 21.9 µM 1.20087297895147 0.101261175560251 no 407 0.114900238666169 583 708623 SGTC_204 PMA1.184 62.41 µM 1.1993338019413 0.101537832404138 no 408 0.115199088308949 665 2252213 YGL008C PMA1 SGTC_2713 st079149 53.4 µM 1.19926008513197 0.101551096310756 no 409 0.11521341516381 648 3103253 SGTC_1550 gossypolone 36.6 µM 1.19829288374617 0.101725242296571 no 410 0.115401508006703 643 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_1957 st077035 62.4 µM 1.19505762114551 0.102309335733727 no 411 0.116032259026172 613 705593 SGTC_1656 st012921 11 µM 1.19193970838026 0.102874547284346 no 412 0.116642443409204 578 6732821 SGTC_2180 6301957 200 µM 1.1918395570444 0.102892740133341 no 413 0.116662080956644 621 845462 SGTC_981 1488-1094 54.9 µM 1.19166429710178 0.102924582354078 no 414 0.116696451345261 562 3449522 SGTC_10 0279-0212 42.575 µM 1.19073689338348 0.103093197500626 no 415 0.116878444856533 731 39851 YBR002C RER2 SGTC_880 0833-0487 87.2 µM 1.18954997556785 0.103309288561607 no 416 0.117111658731091 605 76075 SGTC_2173 5763948 167 µM 1.18778505262642 0.103631219381039 no 417 0.117459052389785 646 2867177 SGTC_460 trequinsin 123 µM 1.18576051953478 0.104001400078951 no 418 0.11785844347272 677 5537 A vasodilator. SGTC_1052 3253-3998 198 µM 1.18335638895273 0.104442233453904 no 419 0.11833396673902 676 5450317 SGTC_2936 9038235 15.59 µM 1.1826394763332 0.104573951820438 no 420 0.118476030131607 617 4749415 SGTC_1046 2001-0062 216 µM 1.18220285997784 0.104654230288017 no 421 0.118562609059982 625 739778 SGTC_1389 3405-0187 19 µM 1.18182692615119 0.1047233871168 no 422 0.11863719074742 577 799890 SGTC_3030 9087619 49.47 µM 1.18119707422348 0.104839328914831 no 423 0.118762221649881 596 25236973 SGTC_3203 9113543 49.47 µM 1.17940230227556 0.105170216395447 no 424 0.119119009406908 604 17018012 SGTC_680 0417-1641 114 µM 1.17922542259614 0.105202867124385 no 425 0.11915421273402 606 2835990 SGTC_427 1354-0053 47.3 µM 1.17865967438958 0.105307349462033 no 426 0.119266859597131 619 6813657 SGTC_1876 myriocin 605 nM 1.17730557097813 0.105557730011078 no 427 0.119536782073192 641 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1 SGTC_47 0149-0135 24.25 µM 1.17697714361396 0.105618522703867 no 428 0.119602314578306 604 5239155 SGTC_1247 0448-0043 5.84 µM 1.17646003001628 0.105714292975204 no 429 0.119705547801346 675 3089013 YGL099W LSG1 SGTC_2728 chlorpromazine 9.18 µM 1.17571910306911 0.105851623236802 no 430 0.11985357117256 531 2726 A thorazine and dopamine antagonist. SGTC_1633 st005664 67.9 µM 1.17552123857677 0.105888319079789 no 431 0.119893122627807 653 2063822 SGTC_297 0986-0032 24 µM 1.1723743742904 0.106473171193782 no 432 0.120523391599887 614 2847425 SGTC_554 4483-2211 187 µM 1.17171267677309 0.106596445429225 no 433 0.120656215871669 628 747107 SGTC_314 1671-0008 2.74 µM 1.16944501616655 0.107019692020718 no 434 0.121112190941907 689 3913060 SGTC_1518 st038567 90.8 µM 1.16776760880653 0.10733355005258 no 435 0.121450258514753 610 77966 SGTC_2591 skatole 100 µM 1.16732709254018 0.107416084517965 no 436 0.121539150806648 623 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite. SGTC_1371 2421-0008 32.7 µM 1.16699469043491 0.107478393152032 no 437 0.121606256882672 632 2827552 SGTC_2133 5320837 200 µM 1.16668017091165 0.10753737368429 no 438 0.121669776756133 607 2841355 SGTC_170 4197-0004 226 µM 1.1652226662594 0.107810997933895 no 439 0.121964436492188 583 218692 SGTC_1797 st048695 56.8 µM 1.16482180021575 0.107886342268913 no 440 0.122045566295577 658 592262 YIL048W NEO1 SGTC_488 nitrendipine 139 µM 1.16375765445202 0.108086536544981 no 441 0.122261118656789 677 4507 Dihydropyridine L-type calcium channel blocker. SGTC_1424 4048-1941 275 µM 1.15978103865603 0.108837011159549 no 442 0.123068982977064 714 X1424 SGTC_2343 7990716 14.84 µM 1.15321206571927 0.110084913504261 no 443 0.12441167615339 679 6456862 SGTC_2006 4011487 200 µM 1.1510118387231 0.110505174855139 no 444 0.124863682568162 688 45595294 SGTC_228 caffeine 993.056 µM 1.15085025268929 0.110536084382934 no 445 0.12489692336856 612 2519 Caffeine is a phosphodiesterase inhibitor. SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM 1.15049921010377 0.11060325610038 no 446 0.124969159679572 587 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding. SGTC_2646 retinol 96.75 µM 1.14920167190671 0.110851792915309 no 447 0.125236415819638 656 445354 A vitamin A analog and teratogen. SGTC_1943 st076331 65.2 µM 1.14742676242106 0.111192415399241 no 448 0.125602642850706 698 24208415 SGTC_168 3970-0862 530.542 µM 1.14691676251874 0.111290427825944 no 449 0.12570801206175 816 3135186 SGTC_2927 9011802 47.9 µM 1.14629289879708 0.111410406827748 no 450 0.12583699009472 641 43912568 SGTC_681 1642-0006 26.6 µM 1.14528953646688 0.111603563626223 no 451 0.12604461948063 641 4446530 SGTC_1663 st014140 55.4 µM 1.14483686757189 0.111690785085311 no 452 0.126138370031731 765 4207120 SGTC_1431 4049-0260 9.09 µM 1.14005449065462 0.112615246388893 no 453 0.127131800087507 682 3854841 SGTC_1463 k081-0032 34.1 µM 1.13779855486907 0.113053223765413 no 454 0.127602304278277 549 977755 SGTC_1029 k015-0030 64.7 µM 1.1372687899929 0.113156250678958 no 455 0.127712968802489 657 2208316 SGTC_1539 benzyladenosine 56 µM 1.13598120916597 0.113406934353496 no 456 0.127982214328899 643 92208 A nucleotide analog. SGTC_316 k060-0003 58.6 µM 1.12933528658048 0.114707151190192 no 457 0.129378210352333 674 6152314 SGTC_582 0987-0078 156 µM 1.12815445732017 0.114939275484236 no 458 0.129627346923167 805 1625765 SGTC_3350 9150499 3.57 µM 1.1273203733267 0.115103438727714 no 459 0.129803525785913 743 4910996 YPR165W RHO1 SGTC_1356 1502-0781 85.8 µM 1.12729354321499 0.115108722158976 no 460 0.129809195710435 672 567702 SGTC_2767 sibutramine 71.45 µM 1.12414087160235 0.115730752671918 no 461 0.130476634353333 708 64765 A serotonin-norepinephrine reuptake inhibitor.  SGTC_1289 0976-0073 69.1 µM 1.12070348973695 0.116411673671538 no 462 0.131207048132138 724 3391136 SGTC_1342 1486-1464 234 µM 1.11879772002941 0.116790415488859 no 463 0.131613222298397 713 3253938 SGTC_3222 9128301 49.47 µM 1.1173849832076 0.117071737978859 no 464 0.131914876538979 693 4911358 SGTC_2514 salinomycin 42.74 µM 1.1172472029488 0.117099200247391 no 465 0.131944321533477 781 23682228 A polyether potassium ionophore. SGTC_172 1112-0046 2.638 µM 1.11719278201816 0.117110048648043 no 466 0.131955953069656 608 2802135 YIL048W NEO1 SGTC_1430 4049-0248 69.1 µM 1.11625106494561 0.117297885599502 no 467 0.132157340875315 762 22774488 SGTC_2802 7925815 54.55 µM 1.11557028806759 0.117433807668697 no 468 0.132303058076664 697 1262923 SGTC_2688 kanamycin b 96.69 µM 1.11548708514261 0.11745042738469 no 469 0.132320874876886 1111 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis. SGTC_1269 0831-0796 3.05 µM 1.11501084158208 0.117545588694236 no 470 0.132422887927175 686 927758 SGTC_3004 9076122 71.4286 µM 1.11378154218767 0.11779147522079 no 471 0.132686458651064 689 44782551 SGTC_2078 5212016 200 µM 1.1136060504572 0.117826607038641 no 472 0.132724114807299 648 1899708 SGTC_3121 9125696 49.47 µM 1.11062007673518 0.118425507904865 no 473 0.133365958624894 675 1235365 SGTC_2815 7968870 71.43 µM 1.1105824227266 0.118433073934319 no 474 0.133374066074285 721 2977326 YHR190W ERG9 SGTC_2047 4141938 200 µM 1.10990942014168 0.118568361719134 no 475 0.133519030393634 635 3807862 SGTC_1510 1123-0200 71.5 µM 1.10715519258638 0.119123157704929 no 476 0.134113418156057 783 5378812 YNL149C | YNL150W PGA2 | YNL150W SGTC_669 0108-0021 26.2 µM 1.10664416825231 0.119226296783239 no 477 0.134223901549882 818 17201 SGTC_1867 st057372 64 µM 1.10623167616968 0.119309595243037 no 478 0.134313127868024 680 688837 SGTC_1811 st050069 61.5 µM 1.10350150604923 0.119861960113323 no 479 0.134904718943129 675 3877702 SGTC_461 N-acetylfarnesylcysteine 136 µM 1.10349476126732 0.119863326938657 no 480 0.134906182656421 647 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ). SGTC_131 0141-0277 33.849 µM 1.10060423819739 0.120450101187208 no 481 0.135534470084213 704 1547771 SGTC_3044 9093193 49.47 µM 1.10018154729023 0.120536076415515 no 482 0.135626514423081 712 25236277 SGTC_17 0960-0276 49.807 µM 1.09975338943794 0.120623207665174 no 483 0.135719792881308 746 6821114 SGTC_2939 9044578 71.43 µM 1.09905022308905 0.120766400066109 no 484 0.13587308000624 684 2653634 SGTC_2869 9037858 32.47 µM 1.09653095596886 0.121280404299584 no 485 0.136423241986648 656 27187042 SGTC_1568 digitonin 820 nM 1.09636581331816 0.121314151882729 no 486 0.136459359272638 748 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1 SGTC_553 k007-0256 45.7 µM 1.09467517894252 0.12166001986668 no 487 0.13682948324857 724 6287000 SGTC_1189 1431-2119 7.28 µM 1.0887985661271 0.122867638855641 no 488 0.138121362041728 736 3107275 SGTC_1623 st003709 20.3 µM 1.08865622929852 0.122896992362302 no 489 0.138152755328554 775 16192618 SGTC_1330 1469-0054 61.8 µM 1.08847997528849 0.122933347276008 no 490 0.13819163600601 745 7102664 SGTC_367 0335-0881 7.1 µM 1.08840378413077 0.122949065127472 no 491 0.138208445671028 739 23828853 SGTC_1591 genipin 88.4 µM 1.08678450854649 0.123283446730638 no 492 0.138566027822912 693 442424 A DNA cross-linking agent. SGTC_3356 9151811 4.48 µM 1.08590200361679 0.123465952689266 no 493 0.138761175192085 704 1859254 YPR165W RHO1 SGTC_719 2810-4230 27.3 µM 1.08462834521505 0.123729684458388 no 494 0.139043147790954 688 721079 SGTC_1113 artemisinin 1.17947 µM 1.08426418882939 0.123805161437293 no 495 0.139123839273177 765 2240 An anti-malaria and mitochondrial poison. SGTC_3311 9131146 2.8755 µM 1.08382225588529 0.123896802081691 no 496 0.139221807653284 716 4900406 YPR165W RHO1 SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM 1.08263310215022 0.124143624564028 no 497 0.139485654170748 702 616764 SGTC_3249 9135183 49.47 µM 1.08074824640781 0.124535552354982 no 498 0.139904557720659 742 4902779 SGTC_2543 pimpinellin 60.67 µM 1.07758951943743 0.125194300709828 no 499 0.140608490708732 705 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo. SGTC_2761 levamisole 97.89 µM 1.07700184817575 0.125317126739095 no 500 0.140739720010303 703 26879 An alkaline phosphatase inhibitor. SGTC_1502 4534-4282 27.7 µM 1.07675423822846 0.125368903552539 no 501 0.140795037162242 687 3278949 SGTC_3352 9151559 45.5865 µM 1.07618241781874 0.125488531891833 no 502 0.140922840724008 697 17159339 SGTC_1385 3091-4834 14.1 µM 1.07572917811037 0.125583409001963 no 503 0.14102419703818 676 4072814 SGTC_2390 9097792 176.6 µM 1.07572447792319 0.125584393158887 no 504 0.141025248382549 685 4497149 SGTC_34 0469-0683 81.75 µM 1.07552141870804 0.125626916206852 no 505 0.141070674024229 730 3690923 SGTC_1734 st037168 69.4 µM 1.07498372960279 0.125739563305797 no 506 0.141191006427599 721 708907 SGTC_1111 tnp00062 510.699 nM 1.07398727675718 0.125948508705109 no 507 0.141414192034551 756 676306 SGTC_514 4466-0038 2.65 nM 1.0730078951891 0.126154110255239 no 508 0.141633786884814 788 5722064 SGTC_1673 st016611 27.3 µM 1.07048656823901 0.12668448840837 no 509 0.142200175845138 761 5226799 SGTC_1963 st076565 50.3 µM 1.07020178368098 0.126744492221268 no 510 0.142264245836284 716 4914280 SGTC_3241 9133421 49.47 µM 1.06841333788827 0.127121768281 no 511 0.142667051574101 717 17018221 SGTC_2614 arthonioic acid 13.39 µM 1.06474895818159 0.127897215222698 no 512 0.143494774297573 674 6710684 SGTC_2712 st079126 47.7 µM 1.0640191608259 0.128052044790907 no 513 0.143660009785724 697 3152970 SGTC_1272 0839-0021 27 µM 1.06284533002097 0.128301350958858 no 514 0.143926049413837 771 5027250 SGTC_1253 0550-0034 176 µM 1.06233273359565 0.12841032532456 no 515 0.144042329589134 691 5969915 SGTC_58 0957-0393 9 µM 1.06222351909426 0.128433551854358 no 516 0.14406711258851 914 6997992 SGTC_595 3909-8003 73.7 µM 1.06211769267349 0.128456060626616 no 517 0.144091129506083 731 699517 SGTC_1102 cgs 12066b 26.1 µM 1.06067186312433 0.128763855922361 no 518 0.144419525624828 714 6438352 A 5-HT1B full agonist. SGTC_2383 9036125 200 µM 1.05636362741721 0.129684046619759 no 519 0.145401058395999 716 79580 SGTC_3097 9117246 49.47 µM 1.05593318441628 0.129776234033987 no 520 0.14549937094243 741 16423892 SGTC_906 1165-0455 526 µM 1.05409127830045 0.130171225163689 no 521 0.145920564432949 723 3252859 SGTC_1163 k060-0048 49.9 µM 1.05303345085471 0.130398448727106 no 522 0.146162830639404 782 6809982 SGTC_955 1216-0110 33 µM 1.05213833746776 0.130590935145036 no 523 0.146368042587397 748 3619719 SGTC_3264 9137442 49.47 µM 1.05139230341208 0.130751513377133 no 524 0.146539224631362 706 17015726 SGTC_677 0929-0063 136 µM 1.04763020501664 0.131563356087367 no 525 0.147404507747163 700 1539583 SGTC_2064 5220758 200 µM 1.04711074516777 0.131675725795709 no 526 0.147524252034633 797 788518 SGTC_118 0083-0097 135.343 µM 1.04488090787197 0.132158837109269 no 527 0.148039007391204 957 5207356 SGTC_854 0422-0053 192 µM 1.04461333244728 0.132216891389256 no 528 0.148100857551008 735 3596728 SGTC_2256 7954252 200 µM 1.04356967064956 0.132443496609815 no 529 0.14834226561338 648 2972920 SGTC_1475 4092-1048 11.7 µM 1.04267631028071 0.132637680087784 no 530 0.148549116614167 802 2881759 SGTC_2552 juarezic acid 87.02 µM 1.04019705389055 0.133177605683503 no 531 0.149124179992887 899 1549512 SGTC_1042 0350-0096 82 µM 1.03826296283298 0.133599855505958 no 532 0.149573823351233 726 3122515 SGTC_1840 st055363 71 µM 1.03552771049191 0.134198584585381 no 533 0.150211266117677 712 676033 SGTC_3290 9121031 71.43 µM 1.0350027838351 0.134313698104566 no 534 0.150333805559612 691 17014854 SGTC_2942 9052777 62.25 µM 1.03447645076057 0.134429188107664 no 535 0.150456740178918 834 6469503 SGTC_2358 9037157 4 µM 1.03432366980098 0.134462724650606 no 536 0.15049243747634 769 2388925 SGTC_1168 k815-0004 80.5 µM 1.03375832411485 0.134586872131739 no 537 0.150624579654992 762 642433 SGTC_2467 5474540 200 µM 1.03316216696864 0.134717870877179 no 538 0.150764007291044 764 5413519 SGTC_2268 7933382 153.85 µM 1.03274253668783 0.134810132307386 no 539 0.150862200811155 836 935025 YOR257W CDC31 SGTC_1781 st038725 66.3 µM 1.0296664924409 0.135487766086308 no 540 0.151583295047802 834 4270275 YIL048W NEO1 SGTC_1290 0986-0249 10.2 µM 1.02956351722493 0.13551049120257 no 541 0.151607474332816 701 53329 SGTC_268 camptothecin 39.6153 µM 1.02924674930609 0.135580413599132 no 542 0.151681869679205 862 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_2831 7999036 19.48 µM 1.02890216013068 0.135656505242454 no 543 0.151762826607352 820 2988270 SGTC_2633 5,7-dihydroxyisoflavone 100 µM 1.02881974684695 0.135674707949082 no 544 0.151782192834304 778 5377381 SGTC_3094 9117742 49.47 µM 1.02838276425825 0.13577125269708 no 545 0.151884906435804 813 17149698 SGTC_1782 st039423 80.636 µM 1.0278169070107 0.13589634026536 no 546 0.152017980875037 711 2068169 SGTC_966 1300-0360 30.2 µM 1.0277918653521 0.13590187776022 no 547 0.15202387178996 762 70588 SGTC_963 1269-2853 151 µM 1.02624675775295 0.136243848323088 no 548 0.152387643306765 721 3668223 SGTC_678 1218-2179 85.9 µM 1.02612357758893 0.13627113646323 no 549 0.152416669002557 732 6820081 YOR116C RPO31 SGTC_1837 st055472 66.5 µM 1.02522022103968 0.136471371599102 no 550 0.152629644552729 784 676091 SGTC_3066 9117245 49.47 µM 1.02511932336618 0.136493748743829 no 551 0.152653444462879 797 17176980 SGTC_3140 9094243 49.47 µM 1.02407247267054 0.136726067996984 no 552 0.152900522614668 820 19291112 SGTC_3218 9131285 49.47 µM 1.02400673903849 0.136740664754447 no 553 0.152916045937744 853 17156417 SGTC_1497 4476-2978 41.3 µM 1.02311789964082 0.136938144316489 no 554 0.153126052361957 835 1528379 SGTC_1406 3909-7906 11.9 µM 1.0229430840894 0.136977007214957 no 555 0.153167378583362 796 X1406 SGTC_2049 5262831 67.185 µM 1.02162572757677 0.137270108518637 no 556 0.153479038048085 769 763417 SGTC_1752 st044819 83.042 µM 1.0201487862465 0.137599225157038 no 557 0.153828951076894 741 441209 YML126C ERG13 SGTC_1131 3454-3128 32.3 µM 1.01995345847631 0.137642791632349 no 558 0.153875267117062 829 710982 SGTC_2102 5377816 72.7585 µM 1.01804142407115 0.138069754496127 no 559 0.15432913523547 820 1379702 SGTC_1125 tnp00248 1.32998 µM 1.01761886944175 0.138164233908251 no 560 0.154429558219138 913 24207736 SGTC_2990 9074105 71.4286 µM 1.0176082245096 0.138166614588382 no 561 0.154432088617449 755 6502001 SGTC_1469 k284-2957 126 µM 1.01483105035927 0.138788669884501 no 562 0.155093184904874 768 23884841 SGTC_2416 tofa 880 nM 1.01321662387336 0.139151158351339 no 563 0.155478350883324 700 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_3211 9128781 49.47 µM 1.01224608249593 0.139369384629137 no 564 0.155710203780765 742 17194361 SGTC_738 1315-0003 72.4 µM 1.00803987841289 0.140317840037678 no 565 0.156717659093582 810 6251474 SGTC_1023 4482-3888 16 µM 1.00593271371776 0.140794628065472 no 566 0.157223969202788 793 3303168 SGTC_2287 7945887 168.79 µM 1.00407368990837 0.14121618095429 no 567 0.157671547973288 845 1245853 SGTC_3069 9117009 49.47 µM 0.999709361637134 0.142209197296947 no 568 0.158725590126406 677 41904981 SGTC_993 3909-8757 62.7 µM 0.999612686321557 0.142231247211016 no 569 0.158748990652088 738 4288324 YLR208W SEC13 SGTC_1321 1326-2144 215 µM 0.99826979599392 0.142537775795106 no 570 0.159074274830688 802 3513030 SGTC_1156 4092-0367 4.88 µM 0.997828905147032 0.142638511030393 no 571 0.15918116560858 804 1357585 SGTC_424 splitomicin 100 mM 0.997418292624487 0.142732371522497 no 572 0.159280757927916 733 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_2479 5617353 43.85 µM 0.995392022302198 0.143196160961837 no 573 0.159772818562127 805 2731746 SGTC_1249 0481-0015 10.2 µM 0.99458544663924 0.143381059571387 no 574 0.159968964288577 750 4227577 SGTC_494 Boc-Gly-Val-Val-CHO 140 µM 0.99324178690444 0.14368943662252 no 575 0.160296069426722 793 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA. SGTC_3294 9122953 26.2835 µM 0.992642500702629 0.143827120213796 no 576 0.160442102583839 813 16459826 SGTC_2941 9056145 11.23 µM 0.992237659748736 0.143920181148803 no 577 0.160540802795785 730 2119517 SGTC_2594 a-mangostin 100 µM 0.991329676381767 0.144129047282948 no 578 0.160762313320551 808 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis. SGTC_2000 st075254 36.4 µM 0.990693328650228 0.144275550012492 no 579 0.160917674831361 790 17234175 SGTC_707 0865-0008 204 µM 0.990051739939679 0.144423360933672 no 580 0.161074415092665 860 723043 SGTC_953 1188-0045 9.7 µM 0.988316743841779 0.144823584936092 no 581 0.161498773829616 822 6144426 SGTC_320 4092-0846 5.34 µM 0.986409859335162 0.14526432039391 no 582 0.16196601444401 832 1359356 SGTC_2671 danthron 100 µM 0.986341002167072 0.145280252115323 no 583 0.161982902853422 807 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin. SGTC_1141 3253-0389 52.6 µM 0.984435262219232 0.145721656296649 no 584 0.162450773664487 817 5402031 SGTC_363 0455-0021 3.06 µM 0.984013088909045 0.145819561198834 no 585 0.162554538668958 815 4597466 SGTC_1319 1306-0155 43.7 µM 0.974020794666725 0.148149751305532 no 586 0.165023107169148 848 3122360 SGTC_2894 9048625 32.47 µM 0.970046538353513 0.14908343096947 no 587 0.166011647680728 833 4092861 SGTC_1712 st032288 53.4 µM 0.969593092872595 0.149190209045972 no 588 0.16612467858526 929 2883011 SGTC_703 3875-0075 71.8 µM 0.969419316961786 0.149231143612579 no 589 0.166168009091815 891 2850814 SGTC_815 1582-0027 36.9 µM 0.968836449013672 0.149368498456643 no 590 0.166313398787776 838 3128206 SGTC_160 3453-0671 289.699 µM 0.967966123588105 0.149573750698234 no 591 0.166530644305762 900 5322268 SGTC_1228 0124-0032 52.5 µM 0.966934030770435 0.149817397005148 no 592 0.166788506553706 876 X1228 SGTC_715 0868-0130 184 µM 0.966081044959562 0.150018961187307 no 593 0.167001814305578 819 2876258 SGTC_2648 atorvastatin 78.68 µM 0.965900076162358 0.150061748124405 no 594 0.167047092122072 819 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11 SGTC_1468 k284-1086 134 µM 0.963839604398069 0.150549484619735 no 595 0.167563173673088 887 15996457 SGTC_2759 disulfiram 3.38 µM 0.962360303176286 0.150900302061428 no 596 0.167934323492692 787 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_1287 0971-0001 34.6 µM 0.961876371969212 0.151015184751825 no 597 0.168055854371953 885 4665869 SGTC_1122 capsaicin 818.572 nM 0.961205332707398 0.151174582184337 no 598 0.168224467803519 861 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_2308 7584454 197.62 µM 0.960491644722513 0.151344233098889 no 599 0.168403917051501 879 893577 SGTC_1999 st074831 12.5 µM 0.958374380162897 0.151848273221709 no 600 0.168937004687925 847 17112523 SGTC_1851 st056236 18.9 µM 0.957713316592746 0.152005875521544 no 601 0.169103669963891 884 5393171 SGTC_2656 pseudo-anisatin 100 µM 0.957383984414923 0.152084431208155 no 602 0.169186739551197 858 6708809 A neurotoxin. SGTC_1569 carminic acid 40.6 µM 0.955778616723397 0.152467745940529 no 603 0.169592046900309 881 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_158 k038-0087 26.446 µM 0.955740941919113 0.152476749271949 no 604 0.169601566136738 905 X158 SGTC_2850 9015429 58.44 µM 0.955710626644804 0.152483994116814 no 605 0.169609226100612 792 6457570 SGTC_1001 4048-4355 44.4 µM 0.954506845440638 0.152771862375861 no 606 0.169913572948464 829 21824233 SGTC_75 0159-0059 199.013 µM 0.953536087127586 0.153004268674717 no 607 0.170159260476259 821 5377270 SGTC_2906 7926292 26.41 µM 0.953310595962556 0.153058286356505 no 608 0.170216362206104 837 2966319 SGTC_2414 st077232 92.9 µM 0.951351673646197 0.153528089141078 no 609 0.170712941868813 779 729801 SGTC_1184 1269-1718 139 µM 0.950843873373071 0.153650029142876 no 610 0.170841818575538 866 5403821 SGTC_774 k060-0086 136 µM 0.950198770945019 0.153805032484127 no 611 0.171005631517745 928 5911235 SGTC_408 cantharidin 100 µM 0.949327657398861 0.154014505312398 no 612 0.171226995585951 869 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_520 3584-0023 682 µM 0.949124653136522 0.154063347957955 no 613 0.17127860857132 790 1340790 SGTC_1477 0139-0234 16 µM 0.94735929958488 0.154488522448133 no 614 0.171727861611415 876 620880 SGTC_3016 9080866 49.47 µM 0.947014528574383 0.154571648860836 no 615 0.171815687858715 874 17066299 SGTC_109 0132-0036 33.701 µM 0.946862552137341 0.15460830070109 no 616 0.171854411126591 732 67274 A color developer. SGTC_1172 0370-0043 85 µM 0.946029465533898 0.15480931648806 no 617 0.172066778791805 859 376585 SGTC_2214 7179297 48.276 µM 0.945738379958553 0.154879593322954 no 618 0.172141020831769 871 769744 SGTC_3195 9113082 49.47 µM 0.944874466378982 0.155088292171621 no 619 0.172361484318209 839 17018038 SGTC_2033 5192550 145 µM 0.940326993431595 0.156189902048024 no 620 0.173524928798994 829 182073 SGTC_2119 5528445 120.635 µM 0.940109198829404 0.156242791102204 no 621 0.173580775410887 877 791935 SGTC_999 SEC7.066 22.7 µM 0.938395735884287 0.156659298467082 no 622 0.174020538245561 933 740511 YDR170C SEC7 SGTC_2904 7225135 42.03 µM 0.938153643321703 0.156718205028252 no 623 0.174082728724292 924 4446116 SGTC_2497 7-hydroxyflavone 100 µM 0.938011488272322 0.156752801339068 no 624 0.174119253118636 799 5281894 SGTC_3014 9081533 49.47 µM 0.934733644752449 0.157551925019109 no 625 0.174962791700951 889 21367265 SGTC_841 0251-0215 91.2 µM 0.934102770156076 0.157706036098276 no 626 0.175125441574642 914 3888614 SGTC_95 0471-0001 561.058 µM 0.933994456558497 0.157732505077992 no 627 0.175153376250001 834 4015405 SGTC_3208 9114115 49.47 µM 0.933540689652732 0.157843425431927 no 628 0.175270435962538 764 650895 SGTC_1706 st031321 9.9705 µM 0.931604490722282 0.15831729207902 no 629 0.175770480737505 903 6103185 SGTC_1915 st067105 30.6 µM 0.929791690146487 0.158761803315538 no 630 0.176239474837597 861 69751 YOR207C | YOR116C RET1 | RPO31 SGTC_2419 paclitaxel 166.5 µM 0.929697132003844 0.158785012055481 no 631 0.176263959919818 901 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_1745 st081495 74 µM 0.926463039556736 0.159580139800037 no 632 0.177102698195005 921 13842402 YBL026W LSM2 SGTC_2284 7945075 39.21 µM 0.92632078321547 0.159615174401866 no 633 0.177139649136609 957 1245402 SGTC_2409 alverine citrate 63.97 µM 0.925765630919153 0.159751944326349 no 634 0.177283895967873 863 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_274 sirtinol 40.1 µM 0.925468151999564 0.159825264171335 no 635 0.177361221292389 871 6836442 NAD-dependent acetyltransferase inhibitor. SGTC_1699 st031318 29.054 µM 0.92432807541087 0.160106463489542 no 636 0.177657764792828 920 5340658 SGTC_3309 9129340 25.759 µM 0.923757592799837 0.160247294093219 no 637 0.177806269487812 934 17158987 SGTC_2372 9071633 200 µM 0.920368487393445 0.161085604955223 no 638 0.1786901152266 959 21321366 SGTC_447 ml7 120 µM 0.919326807420692 0.161343843243229 no 639 0.178962330080868 919 4216 Selective myosin light chain kinase inhibitor. SGTC_233 rapamycin 362 pM 0.91614681691625 0.162133849978106 no 640 0.17979494767148 958 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C SGTC_43 0570-0105 72.5 µM 0.914816441060977 0.162465102053537 no 641 0.180144001074446 944 1114046 YDL195W SEC31 SGTC_2781 5567276 71.43 µM 0.914545976847991 0.162532499134577 no 642 0.180215015312956 851 2853274 SGTC_1443 4112-3303 14 µM 0.91439329774216 0.162570553331968 no 643 0.180255111148584 895 704433 SGTC_3267 9137951 49.47 µM 0.912875689948508 0.162949121593438 no 644 0.1806539621874 888 16643986 SGTC_9 0092-0002 10.449 µM 0.91274140071083 0.162982647711413 no 645 0.180689282128579 886 759368 SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM 0.910455902582923 0.163553923640482 no 646 0.181291063770126 871 6710655 SGTC_1743 st037606 46.3785 µM 0.904486979171564 0.165052021489617 no 647 0.182868617815234 871 590142 YLR208W | YDL195W SEC13 | SEC31 SGTC_1661 st013063 9.66 µM 0.903965372373725 0.165183356667074 no 648 0.183006881555069 968 721395 SGTC_2335 9018011 154.17 µM 0.903910426653263 0.165197195366053 no 649 0.183021449963831 940 6458208 SGTC_1773 st048542 73.5835 µM 0.903646872306096 0.165263584930537 no 650 0.18309133930428 875 3237138 SGTC_3214 9129694 49.47 µM 0.902038065983748 0.165669218941356 no 651 0.183518323479905 863 17158655 SGTC_1962 st076595 64.5 µM 0.900164694149105 0.166142369380661 no 652 0.184016305910779 916 279619 SGTC_2305 7443522 69.23 µM 0.899624124139105 0.166279061236736 no 653 0.184160157285643 942 5415886 SGTC_844 0330-0132 15.3 µM 0.89848136188356 0.16656826611973 no 654 0.184464488667854 979 2828079 SGTC_2695 st077686 51.995 µM 0.892179130898454 0.168169033296474 no 655 0.186148463059365 877 2876092 SGTC_1219 1469-0211 33.1 µM 0.892017290690713 0.1682102706477 no 656 0.186191832338404 919 6822282 SGTC_2845 9003024 42.97 µM 0.891637948157541 0.168306953709944 no 657 0.186293511541813 935 2990173 SGTC_2513 baicalein 25.65 µM 0.889273593768777 0.168910362357567 no 658 0.186928029732757 908 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2 SGTC_1684 st024538 14.6195 µM 0.889173594557844 0.168935913826226 no 659 0.186954895811075 926 6732859 SGTC_280 3448-3607 3.04 µM 0.888827269662702 0.169024424810705 no 660 0.187047958926121 948 626179 SGTC_1198 1612-1005 86.7 µM 0.888457026494466 0.169119081573642 no 661 0.187147480956762 939 6998509 SGTC_2872 9044037 25.97 µM 0.888439214349071 0.169123636303765 no 662 0.187152269719063 917 6465195 SGTC_1157 4092-0394 27.6 µM 0.885996456747985 0.169749018063024 no 663 0.187809718272015 999 3659885 SGTC_1242 0402-0103 60.1 µM 0.885468725356158 0.169884319602895 no 664 0.187951940067564 874 432868 SGTC_470 aa-861 153 µM 0.882945306069983 0.170532237727105 no 665 0.188632911602249 918 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor. SGTC_3175 9106517 49.47 µM 0.881107375717921 0.171005142923214 no 666 0.189129852753628 915 41468073 SGTC_2154 5570129 200 µM 0.880058173809076 0.171275481614778 no 667 0.189413897991062 999 673366 SGTC_1311 1190-0148 100 µM 0.878662682313894 0.171635468866439 no 668 0.18979209907629 1042 1961333 SGTC_1103 duloxetine 36.1 µM 0.878498003507147 0.171677982015455 no 669 0.189836760347405 1033 60835 A selective serotonin reuptake inhibitor. SGTC_5 0352-0601 109.883 µM 0.877513564843168 0.171932263003221 no 670 0.190103877136061 899 762456 SGTC_2564 betulinic acid 100 µM 0.876530973160136 0.172186306582426 no 671 0.190370722967902 991 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14 SGTC_1486 3970-0793 4.53 µM 0.87648519595669 0.172198147859133 no 672 0.190383160447741 964 2844330 SGTC_1762 st045503 25.4615 µM 0.874037461793706 0.172832064610142 no 673 0.191048926446556 951 4645554 SGTC_2231 micatex 6.853 µM 0.873843969219333 0.172882238871106 no 674 0.191101615852822 966 20737 An antifungal of unknown mechanism. SGTC_2300 7976697 71.57 µM 0.873081916415449 0.173079935862326 no 675 0.191309214898539 829 2236109 SGTC_2272 7805186 180 µM 0.872104179872798 0.173333797837806 no 676 0.191575773041803 945 2956062 YPR165W RHO1 SGTC_1804 st050076 49.1 µM 0.871739840431741 0.173428456442752 no 677 0.191675160251774 938 3895976 SGTC_162 k030-0015 37.8 µM 0.870031816197501 0.173872654822478 no 678 0.192141508625238 1021 1809920 YMR134W ERG29 SGTC_1195 1502-0147 41.1 µM 0.869589548827088 0.173987791186158 no 679 0.192262375624661 992 817940 SGTC_1314 1222-0010 41.1 µM 0.869439932148816 0.174026752170877 no 680 0.192303274806941 947 3526027 SGTC_420 mitomycin C 81.9 mM 0.868834612714523 0.174184437204636 no 681 0.192468799100539 932 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_52 0329-0193 875 nM 0.867295443822176 0.174585797822624 no 682 0.192890076222996 906 3739292 SGTC_3062 9077494 49.47 µM 0.866688516853489 0.174744224153275 no 683 0.193056349450593 921 16459633 SGTC_3224 9130643 49.47 µM 0.866353051140183 0.17483183002006 no 684 0.19314829091209 927 17644395 SGTC_2923 7992654 58.14 µM 0.864933821887609 0.175202765851232 no 685 0.193537556318448 927 2985126 SGTC_2202 7226349 200 µM 0.863198091284517 0.175657101800392 no 686 0.194014281481597 921 844334 SGTC_2379 9035213 200 µM 0.863107503090582 0.17568083418127 no 687 0.194039181511038 1000 646551 SGTC_3268 9137683 49.47 µM 0.862049881128921 0.175958061285617 no 688 0.194330034715907 936 1953228 SGTC_1044 1222-0021 1.78 µM 0.861715036300014 0.176045889540724 no 689 0.194422174609669 927 4306703 SGTC_1603 st002045 67.8 µM 0.861123208235644 0.176201191180872 no 690 0.194585094102832 978 5887985 SGTC_2507 purpurin 79.67 µM 0.860519927800824 0.176359587251774 no 691 0.194751251702165 983 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1 SGTC_2206 7254556 146.969 µM 0.860200304237047 0.176443543455495 no 692 0.19483931850426 969 4398905 SGTC_2587 piperic acid 92.2 µM 0.859620750052593 0.176595840663283 no 693 0.194999066503089 887 5370536 SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM 0.859367386320641 0.176662446548492 no 694 0.195068928552256 950 364106 SGTC_1818 st052136 56.3 µM 0.85846759206519 0.176899118595372 no 695 0.195317159105246 909 674169 SGTC_2017 5132927 60.65 µM 0.858157452686582 0.176980740683356 no 696 0.195402763196546 980 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis SGTC_2722 naftopidil 47.16 µM 0.853652645100326 0.178168992374351 no 697 0.196648739862848 974 4418 An a1-adrenergic receptor antagonist or alpha blocker.  SGTC_859 0439-0102 54.6 µM 0.853061939215592 0.178325177395285 no 698 0.196812478317383 1038 610143 SGTC_1786 berberine 21.6 µM 0.852977606249961 0.178347482407398 no 699 0.19683586140338 910 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_569 4130-2812 160 µM 0.85242359519676 0.178494055088382 no 700 0.196989514423502 868 743552 SGTC_3147 9097027 49.47 µM 0.848170670508039 0.179621761507959 no 701 0.198171464355399 1010 25236841 SGTC_279 1273-0055 2.93 µM 0.846577267915911 0.180045418933907 no 702 0.198615394455953 1057 2847562 SGTC_2844 9010103 25.97 µM 0.843591132447163 0.180841067246225 no 703 0.199448960597422 923 2480525 SGTC_1901 st060216 58.6 µM 0.842387646788753 0.181162355135432 no 704 0.199785502691268 1030 688792 SGTC_2153 5569715 200 µM 0.840577869950662 0.181646173852541 no 705 0.200292230317784 977 2054701 SGTC_2301 7769476 200 µM 0.840185407055774 0.18175119994263 no 706 0.20040221958752 948 977820 SGTC_1164 k060-0068 93.7 µM 0.839228933521076 0.182007318693274 no 707 0.200670426973418 1045 5963676 SGTC_13 0199-0087 65 µM 0.832665111484059 0.183771022353618 no 708 0.20251681308383 1041 4589825 SGTC_1045 1348-1485 165 µM 0.832646040629134 0.183776162168155 no 709 0.202522192420452 1104 6810614 SGTC_3233 9132340 49.47 µM 0.831545402344783 0.184072948538799 no 710 0.202832795353989 997 17682950 SGTC_2860 9025725 38.96 µM 0.830125470088943 0.184456272808436 no 711 0.203233923973201 931 40546248 SGTC_3288 9119690 36.221 µM 0.829095550036808 0.184734620020958 no 712 0.203525170800882 930 17595618 YKL019W RAM2 SGTC_662 k832-1615 104 µM 0.827979254358898 0.185036605911448 no 713 0.203841124407816 958 5878478 SGTC_606 k015-0008 38.6 µM 0.827225301167034 0.185240742521278 no 714 0.204054686790507 1079 1970475 SGTC_2706 st078239 82.5 µM 0.826567684146939 0.185418909772951 no 715 0.204241070086014 1038 15434492 SGTC_2639 lactacystin 53 µM 0.826361995298103 0.185474658594935 no 716 0.204299387688952 1007 3870 A proteasome inhibitor. SGTC_1657 st012939 43.4 µM 0.825155682389253 0.185801820678516 no 717 0.204641605162059 985 24207257 SGTC_1655 st012546 55.1 µM 0.824673693956382 0.185932639964644 no 718 0.204778435186483 951 720985 YLR208W SEC13 SGTC_2721 ifenprodil 61.44 µM 0.823298335844105 0.186306247822409 no 719 0.205169179879078 992 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor. SGTC_2998 9066762 71.4286 µM 0.822912228688136 0.186411215096842 no 720 0.205278954048367 1007 4945196 SGTC_32 0928-0142 34.1 µM 0.822114344875137 0.186628244211293 no 721 0.205505911007884 1008 2244242 SGTC_1298 1079-1278 263 µM 0.819779175951559 0.187264322419167 no 722 0.206171002166994 1030 2840950 SGTC_1537 2',6'-dihydroxyflavanone 78 µM 0.819386403089418 0.18737144162107 no 723 0.206282995010961 1068 5106787 A p450 inhibitor. SGTC_2244 6635614 200 µM 0.818297111552097 0.187668717411596 no 724 0.206593777519128 856 836499 SGTC_970 1315-0089 19.5 µM 0.816380417970716 0.188192504322004 no 725 0.207141296415642 989 6811083 YLR033W RSC58 SGTC_171 k064-0041 9.68 µM 0.813042161867132 0.189106921834268 no 726 0.208096942741572 938 53325 SGTC_2232 chlorophetanol 41.5365 µM 0.809344967537199 0.190122847399185 no 727 0.209158373760067 1121 15907 An antifungal of unknown mechanism. YFR051C RET2 SGTC_125 0133-0007 11.75 µM 0.807110708037628 0.190738406213074 no 728 0.209801351694994 1134 26541 SGTC_539 4859-0462 2.54 µM 0.804368447172613 0.191495593673046 no 729 0.210592109091389 1062 46499474 YNL221C | YBR257W POP1 | POP4 SGTC_2586 curcumin 80 µM 0.800701625228498 0.192510942022905 no 730 0.211652200731001 1086 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40 SGTC_2023 5144124 124 µM 0.796300878041726 0.193733851177086 no 731 0.2129285876814 1020 2830192 SGTC_947 3447-0010 211 µM 0.794426082239176 0.194256267471094 no 732 0.213473712562139 1086 748350 SGTC_1295 1013-0063 9.78 µM 0.793550699565699 0.19450048844701 no 733 0.213728521449902 1070 6826038 SGTC_3026 9090633 49.47 µM 0.792781240123423 0.194715312400071 no 734 0.213952644128687 1072 25236842 SGTC_2978 9011784 42.97 µM 0.792632302925481 0.194756910567638 no 735 0.213996041296465 1130 2994934 SGTC_794 k038-0031 316 µM 0.792025927549709 0.194926327044873 no 736 0.214172779219401 1066 6624242 SGTC_3295 9122362 53.5725 µM 0.792025145133684 0.194926545703587 no 737 0.214173007322073 1026 4730473 SGTC_1648 st011736 69.8 µM 0.791017168522368 0.195208364797393 no 738 0.214466986465892 1043 2855514 SGTC_951 1171-0579 82.7 µM 0.78864385487684 0.195872894142538 no 739 0.215160095747438 1095 1616050 YPR165W | YDR526C RHO1 | YDR526C SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM 0.787718355282767 0.196132406209308 no 740 0.215430733283275 1046 442882 SGTC_291 SEC14.278 35.5 µM 0.786868140652722 0.196370991880702 no 741 0.215679529697814 1080 1068044 SGTC_3273 9137859 49.47 µM 0.782897343356086 0.197487597216083 no 742 0.216843698851888 1128 2377234 SGTC_1977 st070720 65.3 µM 0.779473016886514 0.198453608695925 no 743 0.217850563239236 1014 682188 SGTC_2170 morpholine 200 µM 0.775653815096145 0.19953437184096 no 744 0.218976708175134 1063 121171 Reacts with secondary amines. SGTC_1879 gemcitabine 100 µM 0.775227315309409 0.199655282852894 no 745 0.219102675090448 1071 60750 A nucleoside analog which inhibits DNA replication. SGTC_2517 totarol 10 µM 0.774936467161816 0.199737762435906 no 746 0.219188601119404 1050 460178 An antibacterial membrane disruptor. YGL001C ERG26 SGTC_2620 irigenin 100 µM 0.774506349393482 0.199859774076762 no 747 0.219315707437236 1082 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro. SGTC_2446 5162541 200 µM 0.773806829308393 0.200058302863137 no 748 0.219522516662947 1009 1549321 SGTC_1331 1472-0049 76.2 µM 0.773215283131355 0.200226280365784 no 749 0.219697491387428 1064 24051409 SGTC_2281 7943571 200 µM 0.771494450139476 0.200715415746969 no 750 0.220206955364259 1147 1244024 SGTC_1715 st032160 10.2275 µM 0.770190254662282 0.201086602035253 no 751 0.220593521941122 1029 5289825 SGTC_908 3448-7491 47.7 µM 0.768729624041108 0.201502799606823 no 752 0.221026917432076 1122 1203031 SGTC_2302 7771753 200 µM 0.767591454156563 0.20182747153954 no 753 0.221364970545934 1093 2203047 SGTC_3092 9117248 49.47 µM 0.767007935813768 0.20199404613574 no 754 0.221538398616931 1143 17141857 SGTC_624 k048-0052 28 µM 0.76700424036985 0.201995101321154 no 755 0.221539497190942 1040 6835531 SGTC_836 0330-0104 1.35 µM 0.766889118034854 0.202027974642273 no 756 0.221573722082672 1121 46494820 SGTC_471 1-acyl-paf 4 µM 0.766428063316316 0.202159661457375 no 757 0.221710820013919 1067 16759367 SGTC_1810 st050138 53 µM 0.763990307887967 0.202856788311091 no 758 0.222436509199271 1091 3444541 SGTC_1821 st053465 65.6 µM 0.763800102224425 0.202911241904019 no 759 0.222493187954345 1064 675086 SGTC_1386 3228-0095 33.8 µM 0.763308414879112 0.203052046524737 no 760 0.222639742391953 1064 870181 SGTC_616 4092-0450 108 µM 0.762336856332444 0.203330443451279 no 761 0.222929491033792 1118 787165 SGTC_2381 9035592 200 µM 0.75740181335532 0.204748077020193 no 762 0.224404585033561 1026 4749657 SGTC_1925 st057770 10.1 µM 0.757199283960466 0.204806380637448 no 763 0.224465239570713 1060 5989122 SGTC_2318 6029776 164 µM 0.756424751724056 0.205029441958608 no 764 0.224697286242319 1081 818325 SGTC_975 1335-0046 28.5 µM 0.755254742727841 0.205366672262156 no 765 0.225048073977491 1112 16486740 SGTC_2279 7948423 32.93 µM 0.754383776987497 0.205617923451723 no 766 0.225309405038897 1094 1247112 SGTC_203 k066-0004 30.888 µM 0.753439852160843 0.205890427389394 no 767 0.225592821233298 1201 6795412 SGTC_1159 4092-0538 61.2 µM 0.74997341005742 0.206892999396071 no 768 0.226635359683739 1164 717301 SGTC_1465 k213-0056 144 µM 0.746763957510951 0.207823815384093 no 769 0.227603027719164 1044 24048857 YMR208W ERG12 SGTC_1816 st051957 91.6 µM 0.744154382469977 0.208582472768977 no 770 0.228391541056577 1113 674121 SGTC_364 0083-0097 67.7 µM 0.741894517272412 0.209240779565242 no 771 0.229075623983402 1126 5207356 SGTC_1624 st003710 6.25 µM 0.740808439945831 0.209557592405196 no 772 0.229404798527189 1148 24207033 SGTC_1262 0737-0114 49.6 µM 0.740474176095449 0.209655155181812 no 773 0.229506162460786 1171 765919 SGTC_1759 st043059 70 µM 0.738957357285733 0.2100982099726 no 774 0.229966445796921 1141 669426 SGTC_1806 st050005 60.3 µM 0.738757258859922 0.210156698708534 no 775 0.230027204830967 1111 5194765 SGTC_1057 3448-5381 134 µM 0.736902442958266 0.210699316143085 no 776 0.230590839156797 1153 5497911 SGTC_327 1273-0057 3.96 µM 0.734671068849871 0.211353181765246 no 777 0.231269922024163 1088 3108138 SGTC_1875 nocodazole 6 µM 0.731471928003624 0.212292705320499 no 778 0.232245472522957 1141 4122 A microtubule depolymerizer. YJL014W CCT3 SGTC_2597 laccaic acid a 100 µM 0.729299191443658 0.212932183998761 no 779 0.232909333384516 1104 5491415 A textile dye. SGTC_3244 9134489 49.47 µM 0.728204369276228 0.213254836940719 no 780 0.233244245812811 1133 16584271 SGTC_3325 9138760 55.175 µM 0.725439156143258 0.214071035844015 no 781 0.234091329397124 1137 43844959 SGTC_701 4424-0219 185 µM 0.725083300482527 0.214176204471574 no 782 0.234200464298129 1196 2911779 SGTC_124 0136-0217 7.121 µM 0.724955151482365 0.214214084644363 no 783 0.234239772322407 1283 3976905 SGTC_1689 st020265 53.493 µM 0.724465726492541 0.214358791971823 no 784 0.234389930621323 1134 5758320 YPR016C TIF6 SGTC_2565 isoliquiritigenin 100 µM 0.722802797545378 0.214850891468175 no 785 0.234900524181216 1110 638278 Binds to benzodiazepine receptor 65X better than valium. SGTC_1870 st057514 26.5 µM 0.722270525428019 0.21500854175078 no 786 0.23506408529497 1164 5393161 SGTC_3353 9151644 39.2805 µM 0.721589808726605 0.215210256742115 no 787 0.235273353370956 1146 4909158 SGTC_3104 9120930 49.47 µM 0.719581494906874 0.21580601477147 no 788 0.235891354508738 1149 17014836 SGTC_3144 9087057 49.47 µM 0.718186844462899 0.216220293862712 no 789 0.236321044194859 1104 17249618 SGTC_48 0382-0018 55 µM 0.715373782172152 0.217057309996038 no 790 0.237189054207441 1268 762596 SGTC_3177 9107506 49.47 µM 0.713704834907664 0.217554782657596 no 791 0.237704858040319 1121 8897194 SGTC_2622 2-methoxyxanthone 59.94 µM 0.713663610997291 0.217567078826509 no 792 0.237717606460016 1193 71034 A hepatoprotective. SGTC_876 0720-0963 56.8 µM 0.71277554276096 0.217832067061174 no 793 0.237992331007723 1184 765861 SGTC_445 e6 berbamine 66 µM 0.711525868907911 0.218205268894914 no 794 0.238379213109292 1213 6610268 A calcium/calmodulin antagonist. SGTC_1622 st003707 19.4 µM 0.703717841990616 0.220545380592224 no 795 0.240804253426455 1186 10140899 SGTC_866 0495-0101 262 µM 0.702599383373549 0.220881762709512 no 796 0.241152723447891 1161 635694 SGTC_1322 1348-1070 12 µM 0.70132276368006 0.221266071305915 no 797 0.241550805345576 1170 6758089 SGTC_541 4513-1321 94 µM 0.700598859923905 0.221484162271667 no 798 0.241776695056616 1157 747515 SGTC_556 4058-0063 51.5 µM 0.699336964018593 0.221864628151027 no 799 0.242170735853707 1247 6615692 SGTC_516 3992-2719 87.3 µM 0.698661758291602 0.222068358161807 no 800 0.242381719121083 1165 5350887 YDR037W KRS1 SGTC_2566 crystal violet carbinol 226 nM 0.698571114264937 0.222095716337346 no 801 0.242410050473329 1149 68050 Cationic dye that binds acidic phospholipids including cardiolipin. SGTC_187 1488-2104 32.728 µM 0.698552772138602 0.22210125259102 no 802 0.242415783636828 1215 2852859 SGTC_2797 7859098 81.82 µM 0.697866323844431 0.222308501770633 no 803 0.242630398282581 1223 972681 SGTC_1259 0671-0132 43 µM 0.696942622740329 0.222587555225742 no 804 0.242919351121525 1137 X1259 SGTC_3122 9126309 49.47 µM 0.696764082123273 0.222641516015402 no 805 0.242975223788102 1244 17591206 SGTC_775 4577-0580 57.3 µM 0.695471387818945 0.223032432722359 no 806 0.243379968046818 1246 2006902 SGTC_661 1304-0007 33.6 µM 0.695429805162642 0.223045013994786 no 807 0.243392993675648 1198 3117130 SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM 0.695256304766767 0.223097512735468 no 808 0.243447346162306 1212 676296 Flavone; oxidizing agent. SGTC_980 1473-0395 201 µM 0.692666160142709 0.223882089595254 no 809 0.244259540154559 1153 768876 SGTC_107 0358-0022 2.6945 µM 0.690898456142815 0.224418441203744 no 810 0.244814678207183 1156 521106 YGL093W | YPR107C SPC105 | YTH1 SGTC_3269 9137823 49.47 µM 0.688159491938724 0.225250928372068 no 811 0.245676174971438 1153 17682936 SGTC_1002 4049-0206 172 µM 0.687975624119932 0.225306876163785 no 812 0.245734065865793 1239 4662749 SGTC_2940 9060638 45.86 µM 0.685235243767944 0.226141658528108 no 813 0.246597743676328 1202 4027022 SGTC_812 4251-0442 148 µM 0.684838799548729 0.226262569034216 no 814 0.246722824354069 1205 5723007 SGTC_1011 4112-3381 17.4 µM 0.684673245840702 0.226313071643364 no 815 0.246775067657721 1252 2877139 SGTC_2750 bromebric acid 70.15 µM 0.684661399531852 0.226316685636214 no 816 0.246778806190109 1227 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2 SGTC_2035 5154463 94.595 µM 0.682183577538648 0.227073319200203 no 817 0.24756143882248 1203 2769623 SGTC_37 0566-0070 1.56 µM 0.681771912869341 0.227199164106053 no 818 0.24769159352327 1229 1626686 SGTC_361 000s-0510 1.45 µM 0.681616306400103 0.227246742867426 no 819 0.247740800638112 1199 660 SGTC_950 1165-0508 94.1 µM 0.680695916159236 0.227528279307489 no 820 0.248031960473496 1191 6148369 SGTC_778 3456-2434 196 µM 0.679717499258605 0.227827780686068 no 821 0.248341676774596 1261 5539063 SGTC_36 0335-0881 14.2 µM 0.679474197110404 0.227902291882616 no 822 0.248418725674673 1176 23828853 SGTC_31 0508-1974 57.237 µM 0.678464315250956 0.228211714360835 no 823 0.248738671104871 1190 6810525 SGTC_2368 9071271 200 µM 0.674490759476595 0.229431480989521 no 824 0.249999679274407 1216 27209959 SGTC_1072 oxiconazole 14.9 nM 0.672243230011622 0.230123022123572 no 825 0.250714432020565 1252 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_2702 st077768 96.8 µM 0.672226952120922 0.230128034908943 no 826 0.250719612612103 1168 6484119 SGTC_2234 tolnaftate 200 µM 0.671897928471462 0.230229371018208 no 827 0.250824339629828 1218 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7 SGTC_840 0245-0196 390 µM 0.670208505289542 0.230750089956068 no 828 0.251362441358299 1291 3827528 SGTC_181 1447-1644 8.07 µM 0.668891665624668 0.231156425924024 no 829 0.251782293548023 1198 534600 SGTC_2086 5274770 176.623 µM 0.668186067754799 0.231374315768325 no 830 0.252007413827084 1247 689278 SGTC_448 monastrol 171 µM 0.66483504759011 0.232410678770184 no 831 0.253078001656882 1226 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity SGTC_2058 5236698 133 µM 0.664833930471195 0.23241102468918 no 832 0.253078358953847 1234 766665 SGTC_3227 9130768 49.47 µM 0.664220331547364 0.232601070583217 no 833 0.253274651239216 1262 17720899 SGTC_2428 5615643 7.78 µM 0.662813686646489 0.233037067174592 no 834 0.253724943416488 1253 2253075 SGTC_943 3253-1379 105 µM 0.662404703969967 0.233163918496674 no 835 0.25385594491858 1250 668464 SGTC_2773 thioridazine 9.09 µM 0.661911783966394 0.233316855003938 no 836 0.254013879607674 1258 5452 An antipsychotic. SGTC_1302 1159-0335 255 µM 0.661663323422187 0.233393965054391 no 837 0.254093507476252 1251 649284 SGTC_1626 st003712 1.76 µM 0.660917995555309 0.233625363319662 no 838 0.254332452379961 1230 24207035 SGTC_2038 4100038 30.985 µM 0.660591264569597 0.233726841966922 no 839 0.254437236295494 1242 3596803 SGTC_3065 9113888 49.47 µM 0.66038274261862 0.233791619104868 no 840 0.254504121931856 1304 16648368 SGTC_1644 st010134 20.9 µM 0.66019820024294 0.233848955309942 no 841 0.254563323547231 1239 3818134 SGTC_2459 5811157 9.22 µM 0.658719311903596 0.234308718333189 no 842 0.255038014730576 1235 2870684 YBR192W RIM2 SGTC_419 nsc-638432 893 µM 0.65749092047114 0.234690985885753 no 843 0.25543265359253 1257 368090 SGTC_578 3460-0051 92 µM 0.657217305808718 0.234776179953777 no 844 0.255520599771524 1313 2876744 SGTC_2395 5646831 180.19 µM 0.656186351282685 0.23509733677284 no 845 0.255852114809553 1283 6808628 SGTC_882 0843-0131 351 µM 0.655652744932515 0.235263657902341 no 846 0.256023790062582 1275 5425421 SGTC_2793 7325131 81.82 µM 0.6554400021293 0.235329986360459 no 847 0.256092251791092 1244 4176441 SGTC_1785 bathophenanthroline 24 µM 0.655053934216315 0.235450380079419 no 848 0.256216514812925 1232 72812 An iron chelator. SGTC_2686 alizarin 95.37 µM 0.654463072873805 0.235634703601387 no 849 0.256406755203183 1228 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1 SGTC_1368 1852-0141 284 µM 0.653737606818566 0.235861126863699 no 850 0.256640435075129 1244 2838987 SGTC_2118 5526350 200 µM 0.652708190806241 0.236182620869063 no 851 0.256972210498971 1269 743594 SGTC_2666 tannic acid 100 µM 0.65257758055317 0.236223428635925 no 852 0.257014321449712 1280 16134267 A thiamine antagonist. SGTC_1808 st050063 61.5 µM 0.652461561772121 0.236259680710901 no 853 0.257051730873839 1267 4011993 SGTC_24 0417-1663 219 µM 0.651972503552267 0.236412529082725 no 854 0.257209455316024 1246 4329390 SGTC_3085 9117376 49.47 µM 0.651654617021531 0.23651190929639 no 855 0.257312002754222 1310 16480349 SGTC_2394 5221648 200 µM 0.651187076643348 0.236658117248917 no 856 0.257462865826174 1344 788586 SGTC_193 1273-0060 1.558 µM 0.650982687690194 0.236722048820701 no 857 0.257528831236293 1151 2847393 YHR072W ERG7 SGTC_192 3455-0609 60.9 µM 0.650587283121231 0.236845755828502 no 858 0.257656470799634 1299 3769639 SGTC_319 1348-1596 45.5 µM 0.650184588524163 0.236971780134049 no 859 0.257786497391343 1329 5380505 SGTC_3098 9119039 49.47 µM 0.649915256665176 0.237056088794543 no 860 0.257873481314466 1283 17161528 SGTC_2529 gangaleoidin 93.61 µM 0.647608650404778 0.237778797899921 no 861 0.258619050455302 1314 4565183 SGTC_1474 0330-0125 5.35 µM 0.6467215864185 0.238057055442704 no 862 0.258906074852573 1277 X1474 SGTC_256 clotrimazole 625 nM 0.646024617414683 0.238275808423213 no 863 0.259131706389341 1274 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C SGTC_515 4092-1064 102 µM 0.645476215874673 0.238448008907275 no 864 0.259309313242081 1303 717353 SGTC_1205 4161-2785 76 µM 0.643235901274239 0.239152184735281 no 865 0.260035520578202 1253 3498106 SGTC_1299 1079-1439 3.74 µM 0.640988431873929 0.239859749869342 no 866 0.26076509944811 1251 323161 SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM 0.64018591791896 0.240112679718033 no 867 0.261025868388894 1321 5393153 SGTC_1834 st055981 52.8 µM 0.64000850387667 0.240168615256111 no 868 0.26108353541098 1343 471719 YDL150W RPC53 SGTC_905 2-aminofluorene 215 µM 0.639787118095312 0.240238424272229 no 869 0.261155504280522 1297 1539 An established DNA mutagen. YPR165W RHO1 SGTC_1710 st031758 61.5 µM 0.639416338854266 0.240355365911669 no 870 0.261276061335452 1318 5394341 SGTC_971 1315-0384 26.7 µM 0.639125657781235 0.240447066730562 no 871 0.261370594853245 1274 6769120 SGTC_902 1120-0002 2.07 µM 0.637205451320047 0.241053310430678 no 872 0.261995513658267 1271 3280475 SGTC_2771 fluoxetine 41.05 µM 0.636755564954016 0.241195467724764 no 873 0.262142036950747 1310 3386 A selective serotonin reuptake inhibitor. SGTC_433 pimozide 108 µM 0.635459480077971 0.241605265579449 no 874 0.262564392883283 1238 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic SGTC_1711 st032263 62.8 µM 0.635050884195668 0.241734534303125 no 875 0.262697614428271 1297 3958979 SGTC_1878 temozolomide 1 mM 0.633816431189817 0.242125309889585 no 876 0.263100314335126 1263 5394 DNA alkylating agent. SGTC_374 0880-0231 82.3 µM 0.632727732317361 0.242470229917759 no 877 0.263455728311128 1262 6833587 SGTC_1913 st060213 96.1 µM 0.632426228474167 0.242565798977055 no 878 0.263554199835082 1305 688959 SGTC_887 0885-0007 9.62 µM 0.631963287107253 0.242712579328954 no 879 0.263705433601892 1338 5719458 SGTC_1619 st003326 88.7 µM 0.627285984022587 0.244198260025329 no 880 0.265235894614763 1303 2849032 SGTC_1981 st071826 47 µM 0.625056156001473 0.244908256256026 no 881 0.265967101164265 1267 11838600 SGTC_2786 7743617 45.45 µM 0.619499101251653 0.246682493007649 no 882 0.267793806902217 1236 583674 SGTC_2574 2',4'-dihydroxychalcone 14.64 µM 0.618767180374926 0.24691669004612 no 883 0.268034872948333 1344 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_253 dyclonine 31.25 µM 0.618506459907496 0.247000143045286 no 884 0.268120770431999 1374 3180 An oral anasthetic. SGTC_2484 5809818 12.04 µM 0.61572166087132 0.247892459224362 no 885 0.269039119324267 1323 2870548 SGTC_767 0929-0023 86 µM 0.61381730078239 0.248503650887443 no 886 0.269668031697227 1369 1204563 SGTC_2921 7974240 10.71 µM 0.611141836565557 0.249363677904078 no 887 0.270552842511241 1351 2979074 YDR527W RBA50 SGTC_29 0299-0004 12.984 µM 0.608809671081809 0.250114640374261 no 888 0.271325301270654 1229 16871 A napthoquinone isolated from Swertia calycina. SGTC_2445 5742597 35.57 µM 0.60864503119258 0.250167700081948 no 889 0.271379874724507 1296 1774255 SGTC_2731 amoxapine 43.43 µM 0.607970521336073 0.250385141649758 no 890 0.271603512701013 1371 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine. SGTC_3008 9078912 71.4286 µM 0.607748076387029 0.250456873130962 no 891 0.271677285836891 1307 16648731 SGTC_579 4491-1009 110 µM 0.607443115512969 0.250555231092688 no 892 0.271778441317674 1423 1271041 SGTC_1485 3909-9022 254 µM 0.606936055664095 0.250718816619154 no 893 0.271946674482887 1325 714516 SGTC_3320 9137005 35.139 µM 0.606918590590164 0.250724452135661 no 894 0.271952469997005 1317 4908713 SGTC_85 0868-0259 160.055 µM 0.60648438599875 0.250864580012061 no 895 0.272096573807447 1325 83173 SGTC_1056 3448-1962 115 µM 0.605804433598396 0.251084099661487 no 896 0.272322312641177 1351 715507 SGTC_76 0433-0009 400.328 µM 0.603501520112737 0.251828339460881 no 897 0.273087552287994 1342 2841569 SGTC_414 piperonyl butoxide 100 µM 0.602999139968525 0.251990849834655 no 898 0.273254630672778 1299 5794 A potent inhibitor of cytochrome P450. SGTC_3035 9091303 49.47 µM 0.602880697538967 0.252029171756394 no 899 0.273294028875915 1342 25237002 SGTC_2664 lyso-paf C-16 73.48 µM 0.602866128487278 0.252033885769896 no 900 0.273298875259733 1344 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_444 curcumin 90.4 µM 0.601708028518509 0.25240875343757 no 901 0.273684252443172 1320 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. SGTC_2628 lathosterol 100 µM 0.600943832741796 0.252656278321907 no 902 0.273938698542326 1372 6710616 SGTC_2849 9019321 12.99 µM 0.600124957195826 0.252921655945011 no 903 0.274211480499106 1335 16489627 SGTC_941 3237-0776 460 µM 0.599606567077062 0.253089729356777 no 904 0.274384234751316 1396 760008 SGTC_2498 4'-Methoxychalcone 54.63 µM 0.59955959587072 0.253104961351456 no 905 0.274399890627381 1259 641818 YHR062C RPP1 SGTC_2091 4-phenylthiadiazole 200 µM 0.599483342518488 0.253129690094372 no 906 0.274425307414066 1348 270010 SGTC_341 1486-1430 230 µM 0.598824815583867 0.253343301351313 no 907 0.274644856113527 1289 2054753 YPL210C SRP72 SGTC_2889 9059656 51.95 µM 0.598328797738358 0.253504260877252 no 908 0.274810282494584 1395 3949838 SGTC_472 calcifediol 10 µM 0.597498134048724 0.25377393444115 no 909 0.275087426209846 1347 5283731 A vitamin D metabolite. SGTC_1916 st067606 49.2 µM 0.593431064780598 0.255096472543753 no 910 0.276446352147378 1402 19590279 SGTC_3236 9132701 49.47 µM 0.593090380830505 0.255207420275874 no 911 0.27656033380484 1308 24282524 SGTC_811 0416-0114 265 µM 0.592835186197566 0.255290543932755 no 912 0.276645728634314 1352 6612453 SGTC_1490 4089-0339 670 nM 0.592623870821083 0.255359385663303 no 913 0.276716450090674 1323 742542 SGTC_2482 5981709 142.65 µM 0.59244105211671 0.255418951655176 no 914 0.276777641639092 1362 877755 SGTC_2885 9057732 51.95 µM 0.591186447204288 0.255827922844722 no 915 0.27719775125111 1343 6471414 SGTC_965 1291-5240 308 µM 0.591010568248728 0.255885282480943 no 916 0.277256669964156 1398 2834598 SGTC_2085 5307070 144.047 µM 0.590827502495691 0.255944993084773 no 917 0.27731800272944 1306 2840351 SGTC_1578 josamycin 24.2 µM 0.588913632124816 0.256569675718877 no 918 0.277959606265012 1292 5282165 A P450 substrate. SGTC_3235 9132602 49.47 µM 0.588562420211655 0.256684396606566 no 919 0.278077424730783 1381 4912240 SGTC_3025 9087895 49.47 µM 0.587003536451679 0.257193917141844 no 920 0.278600665799 1363 17173641 SGTC_2976 9009005 19.48 µM 0.586908224841612 0.257225086752739 no 921 0.278632672794663 1408 2993148 SGTC_399 oxolinic acid 75 µM 0.586559053935065 0.257339292356045 no 922 0.278749944649784 1329 4628 A DNA gyrase inhibitor. SGTC_483 fpl-64176 144 µM 0.583439566058905 0.258360771715066 no 923 0.279798714545844 1381 3423 SGTC_3080 9117754 49.47 µM 0.582675799549678 0.258611187587217 no 924 0.280055783781043 1478 9550191 SGTC_924 2046-0044 21.3 µM 0.582052836025144 0.258815531447959 no 925 0.280265546152551 1336 3623589 SGTC_2675 theaflavin digallate 100 µM 0.575001850363213 0.261134199658051 no 926 0.282645022788039 1380 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative. SGTC_2386 9075165 157.42 µM 0.574404492375243 0.261331126152686 no 927 0.282847056821919 1341 16452277 SGTC_856 0433-0016 11.3 µM 0.572685768421961 0.261898150077514 no 928 0.283428737586482 1374 3911780 SGTC_3149 9097855 49.47 µM 0.572596676365019 0.261927559613044 no 929 0.283458905312094 1453 25236625 YMR079W SEC14 SGTC_1698 5-fluorocytosine 1.055 µM 0.568742872454006 0.263201329890639 no 930 0.284765324229515 1410 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_710 3448-4187 58 µM 0.568342535883525 0.263333831475665 no 931 0.28490120076941 1410 3946412 SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM 0.568251164636704 0.263364077890576 no 932 0.284932217031619 1461 1377 SGTC_2245 6637752 200 µM 0.56797859975535 0.263454314956713 no 933 0.285024749619833 1418 681890 SGTC_3198 9112019 49.47 µM 0.567839853098472 0.263500255369735 no 934 0.285071857989222 1417 45595555 SGTC_2327 6189656 200 µM 0.565255922704275 0.264356567148103 no 935 0.285949852156622 1475 5349088 SGTC_3299 9121982 43.1275 µM 0.564598954818678 0.264574511267141 no 936 0.286173288171449 1389 17594604 YPL160W CDC60 SGTC_2024 5144227 134 µM 0.563707672173071 0.264870333590626 no 937 0.28647654757717 1419 3475211 SGTC_2596 sinensetin 100 µM 0.563171551652651 0.265048356311679 no 938 0.286659036294418 1377 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets. SGTC_2871 9038510 12.99 µM 0.561543838294248 0.265589222551945 no 939 0.287213427044981 1499 4945164 SGTC_1359 1582-0056 520 nM 0.559979237275238 0.266109644584141 no 940 0.287746799930033 1441 3661189 SGTC_1892 st058411 7.36 µM 0.55738111162609 0.26697497976983 no 941 0.288633533942843 1463 3934738 SGTC_1777 st045864 34.765 µM 0.555564729775441 0.267580789295722 no 942 0.289254224166881 1404 4691462 SGTC_658 3253-0951 102 µM 0.554193989878746 0.268038424292599 no 943 0.289723045528702 1430 1184878 SGTC_1461 k072-0203 53.8 µM 0.553462576248971 0.268282775043269 no 944 0.289973349911511 1348 5418714 SGTC_254 nsc-64875 3.808 µM 0.553374137653179 0.268312328211876 no 945 0.290003622238848 1528 56993 SGTC_934 2950-0684 338 µM 0.552906938526541 0.268468477428753 no 946 0.290163568004836 1500 1121253 SGTC_645 0845-0943 5.41 µM 0.551258750239897 0.26901970635696 no 947 0.290728155637016 1401 1885106 SGTC_1384 3089-0840 101 µM 0.550845158660112 0.26915811925106 no 948 0.290869912208075 1470 1069836 SGTC_1628 st004252 77.7 µM 0.549582565178687 0.269580880712661 no 949 0.2913028599259 1505 692968 SGTC_1094 duloxetine 25.4 µM 0.548931950198399 0.269798859704668 no 950 0.29152607543784 1404 60834 A selective serotonin reuptake inhibitor. SGTC_3079 9117512 49.47 µM 0.548468695291856 0.269954120229596 no 951 0.291685059330829 1484 7185044 SGTC_2040 5100729 123 µM 0.548445540877415 0.269961881636953 no 952 0.291693006726707 1436 11840 YJR013W | YDR381W GPI14 | YRA1 SGTC_3345 9148410 3.559 µM 0.545219371682451 0.271044390793003 no 953 0.292801324915169 1442 4903596 SGTC_1940 st075990 51.1 µM 0.543136180479624 0.271744533555734 no 954 0.293518021689756 1502 1084979 SGTC_357 1325-0123 420 µM 0.542934139146658 0.271812485775502 no 955 0.293587574767408 1427 1098503 SGTC_3002 9075603 71.4286 µM 0.541683748214039 0.272233215640407 no 956 0.29401819365746 1396 20105405 SGTC_526 4469-0568 170 µM 0.541148134281908 0.272413537254058 no 957 0.294202741635508 1410 2901964 SGTC_2097 5376186 200 µM 0.540976191021303 0.272471436835069 no 958 0.294261996736926 1463 742755 SGTC_1237 0330-0133 46.1 µM 0.539780749699703 0.27287415448831 no 959 0.294674122141055 1399 X1237 YHR072W ERG7 SGTC_2075 5212009 200 µM 0.539498133006135 0.272969404907844 no 960 0.294771592433722 1436 780898 SGTC_2448 5185112 27.17 µM 0.538998058258647 0.273137985685322 no 961 0.294944097186307 1394 5718189 SGTC_2258 7960471 200 µM 0.538920135586225 0.273164258932975 no 962 0.294970981418967 1375 2974708 SGTC_818 4072-2707 53.5 µM 0.538321977702265 0.273365981980909 no 963 0.295177390467819 1372 882871 SGTC_2799 7812892 81.82 µM 0.537952525318203 0.273490613119257 no 964 0.295304912286675 1482 20205235 SGTC_112 phenothiazine 287.218 µM 0.537624709144593 0.273601222235829 no 965 0.29541808399071 1461 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.  SGTC_1307 1187-1599 12.2 µM 0.537339371277107 0.273697516677211 no 966 0.295516607182556 1402 1538471 SGTC_868 0527-0199 213 µM 0.536916507615637 0.273840253483613 no 967 0.295662643897689 1444 2849450 SGTC_71 0417-1750 47.813 µM 0.535444779372907 0.274337319280906 no 968 0.296171166277423 1570 6811472 SGTC_2156 5649887 115 µM 0.533477854729502 0.275002328853997 no 969 0.296851418339606 1514 54680440 YKL052C | YBR257W ASK1 | POP4 SGTC_3274 9138298 49.47 µM 0.533150987551437 0.275112918280473 no 970 0.296964533139674 1403 17015756 SGTC_2071 5230951 39.92 µM 0.532837456360312 0.27521901629931 no 971 0.29707305144722 1448 1799272 SGTC_2960 9079389 5.97 µM 0.52890885635821 0.276550147767294 no 972 0.298434338997097 1528 16457355 SGTC_208 k072-0098 12.366 µM 0.528336432627644 0.276744365792412 no 973 0.298632924551467 1428 5948901 SGTC_2824 7998404 51.95 µM 0.528199199699049 0.276790937571897 no 974 0.298680542402578 1460 837851 SGTC_604 1000-0114 314 µM 0.527088395117044 0.277168044795552 no 975 0.299066102594854 1524 1572745 SGTC_3045 9092950 49.47 µM 0.526113647021479 0.277499169121198 no 976 0.299404623617112 1559 44120432 SGTC_78 0336-0123 156.75 µM 0.525205147945101 0.277807962463877 no 977 0.29972029331656 1403 6765896 SGTC_2270 7924575 90.91 µM 0.524321323415924 0.278108529986239 no 978 0.300027534103663 1561 1262135 SGTC_1939 st074455 53.6 µM 0.522782191879046 0.278632330038496 no 979 0.300562916779382 1548 1644229 SGTC_150 3970-0969 77.2 µM 0.52255898510327 0.278708332043162 no 980 0.300640594445656 1487 6615640 SGTC_1908 st060353 56.5 µM 0.521324750575879 0.279128771543401 no 981 0.301070281002337 1600 4227716 SGTC_568 1193-0097 7.48 µM 0.521132651697322 0.27919423735944 no 982 0.301137183213488 1378 3646150 SGTC_157 1348-1695 65.819 µM 0.519081232260842 0.279893810298927 no 983 0.3018520476775 1430 5380510 SGTC_142 0335-0849 62.6745 µM 0.518802445656404 0.279988947393718 no 984 0.301949256140817 1492 3889043 YPR107C YTH1 SGTC_2175 5807670 165.306 µM 0.516888104981146 0.280642647260042 no 985 0.302617135821041 1424 241186 SGTC_570 0987-0065 62.6 µM 0.516799002137081 0.280673091645914 no 986 0.302648238348698 1392 3104428 SGTC_347 4534-1311 26.2 µM 0.516474901162398 0.280783842942924 no 987 0.302761382163986 1429 2862016 SGTC_1391 3442-0225 151 µM 0.515857157248435 0.280994995970172 no 988 0.302977089327451 1458 5227075 SGTC_3131 9127911 49.47 µM 0.515161897445851 0.281232736692009 no 989 0.303219946136867 1498 45595681 SGTC_123 0083-0120 66.675 µM 0.51437679941397 0.281501313864857 no 990 0.303494288354966 1390 16001701 SGTC_843 0310-0051 143 µM 0.513901337204896 0.281664026678256 no 991 0.303660486275702 1467 2065037 SGTC_1080 nisoldipine 24.4 µM 0.51282453026101 0.282032699420422 no 992 0.304037034486078 1447 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class. SGTC_1439 4092-1168 46 µM 0.512537446498475 0.282131029204253 no 993 0.304137459829009 1483 2886240 SGTC_546 peri-Naphthalide 147 µM 0.510680992134531 0.282767286202813 no 994 0.304787226321277 1523 223824 A penicillin ester. SGTC_1775 st081588 35.1725 µM 0.510666651508109 0.282772203804267 no 995 0.304792247999114 1464 1426443 YGL099W LSG1 SGTC_3019 9081971 49.47 µM 0.506033818470646 0.284363013731591 no 996 0.306416454502654 1576 16451803 SGTC_790 1575-0012 79.1 µM 0.505730796588749 0.284467213418603 no 997 0.306522822848351 1511 378741 YLR208W SEC13 SGTC_2641 levomentholum 100 µM 0.505133623743855 0.284672615739329 no 998 0.306732493335617 1453 16666 SGTC_1405 3909-7894 12 µM 0.504184655166519 0.284999166560001 no 999 0.30706581123988 1548 7104060 SGTC_2250 alverine citrate 130 µM 0.502573527231218 0.285553982624572 no 1000 0.307632072705504 1446 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1 SGTC_1266 0828-0227 32.9 µM 0.502321293560287 0.285640889592257 no 1001 0.307720766567575 1520 3913820 SGTC_1697 st025554 27.742 µM 0.501672411485821 0.285864519357783 no 1002 0.30794898701362 1460 1269519 SGTC_2424 5537928 59.2 µM 0.500750596600837 0.286182355346448 no 1003 0.308273329295033 1460 5382802 SGTC_2179 6298986 200 µM 0.500446340099783 0.286287297909428 no 1004 0.308380415391389 1573 738374 SGTC_1653 st012112 65 µM 0.50003668297432 0.286428623560593 no 1005 0.308524624041087 1512 720429 SGTC_923 1900-2434 73.3 µM 0.499425073176617 0.286639681491788 no 1006 0.308739979610555 1430 5910570 SGTC_3101 9120531 49.47 µM 0.498404738567501 0.286991948664552 no 1007 0.30909939877386 1538 24824904 SGTC_1429 4049-0205 9.46 µM 0.498149896400491 0.28707996407972 no 1008 0.309189197045004 1492 22774478 SGTC_1341 1486-1360 280 µM 0.498130223947712 0.287086758930594 no 1009 0.309196129465486 1455 3976547 SGTC_396 dithiazanine 1.25 µM 0.497681683263617 0.287241705215572 no 1010 0.309354210168316 1435 10578 An antihelmenthic. SGTC_151 3013-0144 2.285 µM 0.496280925138934 0.28772584519467 no 1011 0.309848111164014 1560 906558 YHR107C CDC12 SGTC_2635 hydroquinidine 100 µM 0.494661338115204 0.288286098514802 no 1012 0.310419598335162 1502 442912 An experimental heart treatment. SGTC_3341 9147222 25.867 µM 0.493645982263849 0.28863759619484 no 1013 0.310778110265111 1486 1939759 SGTC_2511 berberine 10.47 µM 0.492181545705719 0.289144912667917 no 1014 0.311295504566265 1488 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_3279 9140807 49.47 µM 0.492101124138006 0.289172784797121 no 1015 0.311323928806633 1488 45595718 SGTC_1736 st036774 51 µM 0.492066951192803 0.289184628678373 no 1016 0.311336007250578 1668 1272247 SGTC_1401 3807-4679 7.6 µM 0.49056045146093 0.289706987637785 no 1017 0.311868681993297 1503 3291456 SGTC_1513 0337-0559 19 µM 0.489622291063739 0.290032505989659 no 1018 0.312200599875766 1435 775073 SGTC_3049 9092223 49.47 µM 0.489041472902806 0.290234121358276 no 1019 0.312406167765406 1494 8623917 SGTC_684 1140-0066 328 µM 0.488509093686771 0.290418980102181 no 1020 0.31259464304707 1476 6813534 SGTC_507 nimesulide 162 µM 0.486943720104189 0.290962845919675 no 1021 0.313149107473489 1568 4495 A COX2 inhibitor. SGTC_524 r073-0010 27.8 µM 0.486578323265756 0.291089866104951 no 1022 0.313278594061462 1443 2772106 SGTC_3138 9097216 49.47 µM 0.486306650267674 0.291184322551872 no 1023 0.313374882422317 1471 25237486 SGTC_3040 9091894 49.47 µM 0.486079050482034 0.291263466448166 no 1024 0.31345555982193 1485 25236966 SGTC_2655 perillic acid 100 µM 0.4826170502797 0.292468553333133 no 1025 0.314683835235587 1475 5702197 An apoptosis inducer. SGTC_1115 galangin 695.678 nM 0.482211515037079 0.292609867514117 no 1026 0.314827848797167 1548 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_3114 9122766 49.47 µM 0.481930273046265 0.292707888673217 no 1027 0.314927739914571 1439 17176985 SGTC_1124 fisetin 1.16336 µM 0.481594468269794 0.292824946549458 no 1028 0.315047028296735 1490 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster. SGTC_758 0868-0029 16 µM 0.480016494069019 0.293375301902587 no 1029 0.315607832361373 1619 762687 SGTC_2370 9071495 200 µM 0.479140926858527 0.29368088301746 no 1030 0.315919187905949 1482 21791103 SGTC_826 1683-5028 118 µM 0.478207865494802 0.294006692184752 no 1031 0.31625113241684 1522 722377 SGTC_2164 5685496 200 µM 0.476880927319883 0.294470324025482 no 1032 0.316723457048457 1550 759046 SGTC_3159 9100096 49.47 µM 0.476442801610523 0.29462347910174 no 1033 0.316879473907307 1437 25236875 SGTC_1220 1838-0075 193 µM 0.475110651001451 0.295089382959431 no 1034 0.317354053610772 1532 5529645 SGTC_101 0490-5701 117.494 µM 0.474869213762626 0.295173859074944 no 1035 0.317440097999032 1571 4661669 SGTC_2280 7785178 200 µM 0.473565155832186 0.295630326320038 no 1036 0.317905013936394 1542 2954328 SGTC_1596 piperlongumine 63 µM 0.473538642396027 0.295639610342378 no 1037 0.317914469349525 1623 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_1873 rapamycin 2 nM 0.471995435264688 0.296180215009793 no 1038 0.318465023400157 1514 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1 SGTC_1420 4'-methoxyflavone 42 µM 0.469677608975681 0.296993029374888 no 1039 0.319292683744725 1582 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13 SGTC_79 0052-0007 94.094 µM 0.46897895534995 0.297238232923406 no 1040 0.319542339258783 1615 2801472 SGTC_1267 0828-0272 9.49 µM 0.468928956091543 0.297255784501644 no 1041 0.319560209033707 1635 745334 SGTC_103 0844-0104 51.839 µM 0.468772098557969 0.297310850337222 no 1042 0.319616272760458 1565 5375804 SGTC_1766 st045414 44.774 µM 0.464549676488137 0.298794906457919 no 1043 0.321126988604404 1533 253960 SGTC_1926 methyl fluorone black 53.6 µM 0.463784204623623 0.299064307189349 no 1044 0.321401180561191 1432 72721 Reacts with homocysteine. SGTC_1906 st060206 94.7 µM 0.460093200337933 0.300364866996326 no 1045 0.32272466227099 1625 5133468 SGTC_177 1327-0068 8.361 µM 0.458179046533554 0.301040341751023 no 1046 0.323411906192767 1509 15389900 YOR207C | YLR033W RET1 | RSC58 SGTC_1231 0242-0792 125 µM 0.457488716125039 0.301284116372514 no 1047 0.323659905475896 1510 3707635 SGTC_1145 3546-0597 10.2 µM 0.455882966543276 0.30185149422151 no 1048 0.324237069420323 1538 875334 SGTC_1428 4049-0204 61.7 µM 0.455356723492896 0.302037542105716 no 1049 0.324426312044018 1638 X1428 SGTC_2351 9026858 72.31 µM 0.454417162400803 0.302369842367381 no 1050 0.324764300998232 1466 1409300 SGTC_3134 9127454 49.47 µM 0.454225689473251 0.302437581866273 no 1051 0.324833197397383 1596 24262820 SGTC_1713 st033146 12.748 µM 0.453767546763938 0.302599691702612 no 1052 0.324998072086124 1663 674619 SGTC_2932 9016711 44.54 µM 0.453257307668157 0.302780281215008 no 1053 0.325181735374822 1678 7117328 SGTC_2235 salicylic acid 500 µM 0.452714550213838 0.302972432948367 no 1054 0.325377150447492 1575 338 A COX inhibitor and kinase inhibitor. SGTC_1312 1218-2183 165 µM 0.451655823555782 0.303347409564107 no 1055 0.325758473875353 1559 6744073 SGTC_398 bronopol 33.3 µM 0.451653228611725 0.303348328888323 no 1056 0.325759408725082 1589 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them. SGTC_2261 9010538 184.68 µM 0.451269939439234 0.303484132392343 no 1057 0.325897503801137 1483 6457250 SGTC_285 1486-1325 46 µM 0.449058073128734 0.304268350507269 no 1058 0.326694882252137 1603 22310230 SGTC_2015 5119600 184 µM 0.44835113505463 0.30451918588391 no 1059 0.326949900884783 1670 2828786 SGTC_1616 st002734 56.1 µM 0.447908707158116 0.304676214699768 no 1060 0.327109542077688 1575 4026101 SGTC_1814 st052110 31.539 µM 0.446857112865263 0.305049596449972 no 1061 0.327489115618536 1644 674163 SGTC_3091 9116372 49.47 µM 0.446473490162674 0.305185857069286 no 1062 0.327627628875657 1552 17169793 SGTC_912 3474-0017 2.18 µM 0.445103818356494 0.305672577007507 no 1063 0.328122364770603 1659 3360550 SGTC_2663 amphotericin b 100 µM 0.444128440299553 0.306019392121648 no 1064 0.328474862728951 1558 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_1685 st024049 53.0905 µM 0.443729545927839 0.306161277108416 no 1065 0.328619065672168 1556 1941139 SGTC_226 1,3-diallylurea 8.28947 mM 0.443525980530568 0.306233695640138 no 1066 0.328692665742772 1578 74537 YKL182W FAS1 SGTC_585 0kpi-0023 191 µM 0.443476064243976 0.306251454549843 no 1067 0.328710714236338 1643 64601 SGTC_201 4262-0159 12.803 µM 0.442804330500997 0.306490484122112 no 1068 0.328953635380397 1649 1341029 SGTC_1904 st060225 78 µM 0.442339693140697 0.306655868757517 no 1069 0.329121705907878 1521 66595 SGTC_1726 st035556 14.5795 µM 0.440808869034614 0.307201034032962 no 1070 0.329675686119013 1658 5919439 SGTC_2454 5-benzylidenerhodanine 10.36 µM 0.440467736976824 0.307322577944876 no 1071 0.329799187220433 1717 1273210 SGTC_1448 4255-0083 152 µM 0.439233513198623 0.307762503405802 no 1072 0.330246172052452 1708 5399660 SGTC_1240 0356-0016 42.1 µM 0.438201428349887 0.308130591011169 no 1073 0.330620136630491 1605 4305613 SGTC_1716 st033144 30.6155 µM 0.437297085538617 0.308453278814651 no 1074 0.3309479543556 1676 674617 SGTC_1749 st037932 54.2 µM 0.433923920751349 0.309658196469683 no 1075 0.332171844265476 1555 594497 SGTC_1446 4239-0190 62 µM 0.430813780244997 0.310770975850953 no 1076 0.333301889465247 1555 1340085 SGTC_144 4161-2749 112.381 µM 0.429606052409035 0.311203557401866 no 1077 0.333741116825086 1505 797501 YMR168C CEP3 SGTC_2099 5377090 177.372 µM 0.429168474135688 0.311360352734547 no 1078 0.333900311902101 1559 2243829 SGTC_1363 1636-0063 10.4 µM 0.428445420405398 0.311619516119929 no 1079 0.334163431134654 1589 6072185 SGTC_83 0170-0301 39.027 µM 0.428360781069281 0.311649859413156 no 1080 0.334194236718974 1592 3089716 SGTC_968 1309-0633 340 µM 0.426525464467071 0.312308136655519 no 1081 0.334862498390957 1650 3761976 SGTC_1400 3771-8998 51.5 µM 0.425560235576056 0.31265457824677 no 1082 0.335214160376524 1638 670767 SGTC_2433 5607874 27.82 µM 0.424897710341575 0.312892468787264 no 1083 0.335455621929384 1533 2252428 SGTC_1613 st002381 52.1 µM 0.424730657724868 0.312952464073059 no 1084 0.3355165160576 1572 551167 SGTC_1185 1319-0113 81.3 µM 0.422585574097847 0.313723289273086 no 1085 0.336298826797684 1642 4672763 SGTC_1234 0326-0494 15.5 µM 0.422563118164705 0.313731363011994 no 1086 0.336307020220932 1683 1547813 SGTC_1562 morin hydrate 59.1 µM 0.422184621001287 0.313867460168694 no 1087 0.336445132945666 1619 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase. SGTC_1357 1503-1303 39.5 µM 0.421759331885657 0.314020412640185 no 1088 0.336600346276074 1583 292895 SGTC_1200 1643-0193 18.4 µM 0.420660897054496 0.314415605400357 no 1089 0.337001359341924 1611 5403974 SGTC_2838 9002687 71.43 µM 0.420632897210448 0.314425681912987 no 1090 0.337011583859307 1543 6457060 SGTC_28 pentachloropyridine N-oxide 1.606 µM 0.4204769516602 0.314481805730065 no 1091 0.337068531664684 1651 140250 A respiratory chain inhibitor. SGTC_2117 5521686 200 µM 0.419407470251486 0.314866820802337 no 1092 0.337459182767898 1550 803312 SGTC_571 k831-0106 44.2 µM 0.41807407083738 0.315347128718268 no 1093 0.337946481038074 1705 4783639 SGTC_3266 9136860 49.47 µM 0.417857896587887 0.315425026945261 no 1094 0.338025508742229 1573 4871271 YPR165W RHO1 SGTC_2804 7954240 19.48 µM 0.417517102344886 0.315547848553789 no 1095 0.338150108783977 1713 828705 SGTC_711 k292-0785 179 µM 0.417070209548212 0.315708938764988 no 1096 0.338313527088618 1566 4146315 SGTC_3180 9109287 49.47 µM 0.416432931873529 0.315938717054632 no 1097 0.338546617401541 1600 18891271 SGTC_2162 5663267 200 µM 0.414329030538804 0.316697809201368 no 1098 0.339316577977148 1700 6456493 SGTC_1206 3978-0017 132 µM 0.412509851673221 0.317354795859786 no 1099 0.339982880656523 1694 3873677 SGTC_1730 st033808 45.1 µM 0.412369411018435 0.317405539217111 no 1100 0.34003434006207 1600 1045166 SGTC_1062 mesoridazine 14.2 µM 0.411758561875816 0.31762628827376 no 1101 0.340258198329227 1613 4078 A neuroleptic. SGTC_1964 st076914 61 µM 0.41132455430338 0.317783169625539 no 1102 0.340417283578138 1599 24208661 SGTC_2987 9018338 71.43 µM 0.409147384531136 0.318570647619207 no 1103 0.341215752119664 1627 5055682 SGTC_3135 9127742 49.47 µM 0.408219118842394 0.318906649101612 no 1104 0.341556406505186 1603 3643468 SGTC_1606 st000094 49.2 µM 0.406676554295968 0.319465335647231 no 1105 0.342122781341841 1760 1242210 SGTC_2966 9084041 48.03 µM 0.406203218443013 0.319636850863534 no 1106 0.342296644745322 1467 17741380 SGTC_2264 7948757 110.76 µM 0.405945195377247 0.319730362846284 no 1107 0.342391434593504 1569 2971411 SGTC_1686 st019653 115.5 µM 0.40496298986987 0.320086435765291 no 1108 0.34275235789819 1720 97252 SGTC_1791 st048313 56.1 µM 0.404307735073109 0.320324073467149 no 1109 0.342993219072241 1719 1204976 SGTC_2072 5231554 129 µM 0.403969407307517 0.320446801820046 no 1110 0.343117607931032 1765 789545 SGTC_1571 st070080 73.4 µM 0.402716521366987 0.320901456958285 no 1111 0.343578389246365 1724 4315245 SGTC_3194 9111903 49.47 µM 0.402560073632969 0.320958248582187 no 1112 0.343635943304804 1677 17087251 SGTC_693 4161-2696 114 µM 0.402251284057223 0.321070353655114 no 1113 0.343749551581124 1710 805759 SGTC_690 glyoxal 20.3 µM 0.401932996749847 0.321185923920321 no 1114 0.343866668984082 1595 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins. SGTC_2589 lobaric acid 100 µM 0.401102364872454 0.32148760828664 no 1115 0.34417237989746 1575 73157 A novel microtubule depolymerizer. SGTC_1530 rhein 70.4 µM 0.401015779771069 0.321519062659654 no 1116 0.344204253081741 1628 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death. SGTC_342 k048-0088 23.3 µM 0.400966766373397 0.321536868665359 no 1117 0.344222296088072 1575 6820570 SGTC_1516 st013856 110 µM 0.400846712960802 0.321580484426535 no 1118 0.344266492124348 1609 5281404 A mutagen and neurotoxin. SGTC_1275 0867-0008 21.1 µM 0.397672164876215 0.322734698008446 no 1119 0.3454359290241 1649 3422836 SGTC_3169 9102970 49.47 µM 0.39435552221814 0.323942401598922 no 1120 0.346659288351711 1666 17027839 SGTC_1733 st037357 54.9 µM 0.394085862947002 0.324040675544068 no 1121 0.346758823983682 1535 1272339 YGL099W LSG1 SGTC_3037 9091026 49.47 µM 0.391770389450658 0.324885025034088 no 1122 0.347613937733985 1661 25236398 YIL048W NEO1 SGTC_1203 3992-3522 103 µM 0.390448641654967 0.325367411251602 no 1123 0.348102412740264 1861 5322312 SGTC_734 2023-0417 80 µM 0.390423134642674 0.325376723194353 no 1124 0.348111841784912 1692 3935732 SGTC_1515 3460-0031 42.1 µM 0.388484056645378 0.326084948639415 no 1125 0.348828925192401 1628 2876596 SGTC_412 gemfibrozil 100 µM 0.38847325588311 0.326088895251283 no 1126 0.348832920898645 1667 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels. SGTC_3276 9139060 49.47 µM 0.387642104135039 0.326392657524356 no 1127 0.349140452991255 1675 4870619 SGTC_1556 plumbagin 1.48 µM 0.384929652697649 0.32738478162031 no 1128 0.350144767905293 1637 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_2801 7907800 81.82 µM 0.38449556242212 0.327543670807087 no 1129 0.350305592144303 1636 6620925 SGTC_2429 5902844 64.44 µM 0.38190736842188 0.328491669806152 no 1130 0.351265037306543 1774 1927790 YGL093W | YPR107C SPC105 | YTH1 SGTC_2576 guaiol 23.12 µM 0.381857211615312 0.328510052084975 no 1131 0.351283639856288 1821 227829 SGTC_2778 tioconazole 65.09 nM 0.380845920890398 0.328880774791338 no 1132 0.351658791250071 1602 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_956 1185-0240 191 µM 0.379624393731067 0.329328791308378 no 1133 0.352112125245717 1668 1416193 SGTC_2881 9058953 51.95 µM 0.379490078020182 0.329378068923811 no 1134 0.352161985426241 1570 17122249 SGTC_1794 st048918 76.9 µM 0.379160098263968 0.329499144153735 no 1135 0.352284490078812 1773 672303 SGTC_612 0302-0167 22.4 µM 0.377183845558927 0.330224638904453 no 1136 0.353018492307129 1758 235821 SGTC_2817 7995342 71.43 µM 0.376031126621794 0.330648104391607 no 1137 0.353446877829763 1571 18879975 SGTC_385 1494-0393 12.4 µM 0.373352433478337 0.331632992077299 no 1138 0.354443078353438 1700 3090647 SGTC_1462 k081-0014 26.5 µM 0.372603836934218 0.331908440672326 no 1139 0.354721658356158 1573 3270634 SGTC_401 neomycin 50 µM 0.371202272591545 0.332424395208791 no 1140 0.355243440282314 1696 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis. SGTC_1478 0453-0656 35.7 µM 0.37009368505825 0.332832721977134 no 1141 0.355656343593414 1686 5258496 SGTC_1754 st042065 16.137 µM 0.367351452492579 0.333843621590069 no 1142 0.356678439595956 1662 1126236 YIL048W NEO1 SGTC_2758 dehydroepiandrosterone 69.35 µM 0.36682705820757 0.33403707258491 no 1143 0.356874011488743 1684 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem] SGTC_3342 9147791 14.508 µM 0.365779555427627 0.334423632246977 no 1144 0.35726478833704 1672 1838168 SGTC_889 0919-1524 82.7 µM 0.365197404107499 0.334638539340258 no 1145 0.357482027950598 1656 3905452 SGTC_2141 5621638 7.665 µM 0.364339730355355 0.334955257053283 no 1146 0.357802167557212 1801 2856238 SGTC_1757 st041620 31.8375 µM 0.364315581408751 0.334964176362754 no 1147 0.357811182963347 1654 5289815 SGTC_1680 diphenhydramine 100 µM 0.363541720676465 0.335250047753906 no 1148 0.358100126512845 1672 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1 SGTC_1517 deoxycholic acid methyl ester 49.2 µM 0.361634760661123 0.335954903694218 no 1149 0.358812492536247 1646 229346 A bile salt which induces apoptosis. SGTC_1015 4130-4525 82 µM 0.360666036227487 0.3363131876489 no 1150 0.359174558645312 1629 1363237 SGTC_663 1486-0733 13.9 µM 0.358822161191896 0.336995557862251 no 1151 0.359864066486115 1704 722445 YPR165W RHO1 SGTC_3252 9135871 49.47 µM 0.358413849542166 0.33714673605993 no 1152 0.360016814371459 1743 17682838 SGTC_2247 cerulenin 830 nM 0.357994832334239 0.33730190535883 no 1153 0.36017359040887 1774 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12 SGTC_605 1315-0399 119 µM 0.35712875462947 0.337622716571374 no 1154 0.36049770944843 1745 24020461 SGTC_1952 st077036 64.1 µM 0.356315591464126 0.337924034707215 no 1155 0.360802117133769 1659 2937007 SGTC_998 3996-0085 177 µM 0.354971415507792 0.338422347699071 no 1156 0.361305502837388 1809 715391 SGTC_977 1348-1378 135 µM 0.354084579915518 0.3387512705016 no 1157 0.361637748950928 1674 X977 SGTC_1531 st059297 52.4 µM 0.353339026333553 0.339027887714983 no 1158 0.361917145594058 1737 7566702 SGTC_583 1488-1091 88.9 µM 0.350864565667648 0.339946589963509 no 1159 0.362844978023183 1841 4303273 SGTC_2974 9094440 9.66 µM 0.350109663010946 0.340227055126757 no 1160 0.363128199627893 1788 25236134 SGTC_65 0798-0905 34.986 µM 0.349806673163764 0.340339648284823 no 1161 0.363241895307406 1868 3602145 SGTC_2135 5326629 150.42 µM 0.348801854388941 0.340713147841845 no 1162 0.363619035573247 1668 5020077 SGTC_115 0527-0192 112.043 µM 0.348362769001801 0.340876408630305 no 1163 0.363783879733392 1698 4233931 SGTC_1089 terbinafine 2.25 µM 0.347530584891525 0.341185913195791 no 1164 0.364096372617844 1785 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_2081 5214970 32.255 µM 0.347355147882974 0.341251175091098 no 1165 0.364162262391241 1799 2063512 SGTC_2979 9012552 45.46 µM 0.347267561655362 0.341283758609537 no 1166 0.364195159100968 1739 17100905 SGTC_629 3448-6466 76.7 µM 0.346530190318378 0.341558119779625 no 1167 0.364472149721981 1715 573744 SGTC_2151 5563267 85.4165 µM 0.344714642482277 0.342234005589209 no 1168 0.365154454507586 1710 5310824 SGTC_3296 9122258 64.045 µM 0.344648434299774 0.342258662910047 no 1169 0.365179344426118 1721 4730474 SGTC_2165 5727197 32.143 µM 0.344527568266149 0.34230367769956 no 1170 0.365224783563613 1757 1361712 SGTC_1650 st011916 45.8 µM 0.34305792760764 0.342851202995453 no 1171 0.365777440731978 1816 242528 SGTC_3303 9125618 40.5795 µM 0.341942505738024 0.343266982014045 no 1172 0.366197080308854 1799 22695467 SGTC_2464 5717415 7.67 µM 0.339299033691166 0.344253106389337 no 1173 0.367192235261523 1632 5285744 SGTC_2355 9061122 103.12 µM 0.338747640295062 0.344458932742293 no 1174 0.367399924219469 1832 5302957 SGTC_2233 sulbentine 40.3845 µM 0.338495399645827 0.344553105510945 no 1175 0.367494946632144 1718 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58 SGTC_2662 daunorubicin 22.37 µM 0.334105426694249 0.346193618263676 no 1176 0.369150002617663 1726 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_1973 st070275 50.2 µM 0.331787276181751 0.347061068666441 no 1177 0.370024946355857 1801 17118334 SGTC_51 1013-0126 23.419 µM 0.331350112093093 0.347224745203801 no 1178 0.370190021563472 1872 1627850 SGTC_2378 9074213 121.43 µM 0.330212789770001 0.347650698124402 no 1179 0.370619591763414 1703 657714 SGTC_1489 4065-0444 182 µM 0.329923193946354 0.347759189061308 no 1180 0.370728998806088 1855 2877968 SGTC_1507 4075-3230 155 µM 0.329012518649812 0.348100435469065 no 1181 0.371073112913594 1834 659771 SGTC_2037 5169046 200 µM 0.32879008976539 0.348183802277371 no 1182 0.371157177119336 1770 5718022 SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM 0.328450425428771 0.348311123331856 no 1183 0.371285560854542 1753 368090 SGTC_473 2-arachidonoylglycerol 10 µM 0.326475097482106 0.349051901070307 no 1184 0.372032463690311 1702 5282280 An endocannabinoid. SGTC_2592 piperlongumine 83.33 µM 0.326432000799522 0.349068069401537 no 1185 0.372048764610031 1667 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_2065 5221596 34.26 µM 0.325666022325111 0.349355482768856 no 1186 0.372338527084562 1770 788581 SGTC_2549 cedrol 20.94 µM 0.325296304640659 0.349494240577208 no 1187 0.37247841369475 1834 6708665 A sedative which affects the nervous system. SGTC_400 oxethazaine 37.5 µM 0.320142970743771 0.3514304118971 no 1188 0.37442997624023 1738 4621 A local anesthetic. SGTC_140 0062-0056 502.533 µM 0.320018648339273 0.351477169262053 no 1189 0.374477097007924 1671 3758964 SGTC_3332 9141069 11.198 µM 0.319909825624244 0.351518099074786 no 1190 0.374518344610856 1684 17332883 SGTC_1974 st069448 26.9 µM 0.319557890834054 0.35165047867477 no 1191 0.374651749995245 1866 6323587 YNR016C ACC1 SGTC_3304 9125678 46.087 µM 0.319042535673654 0.351844360993747 no 1192 0.37484712902975 1711 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2 SGTC_1504 k297-0033 30 µM 0.317746671309701 0.352332049685856 no 1193 0.375338552910433 1681 4388117 SGTC_974 1326-0144 138 µM 0.317109090523451 0.352572087570179 no 1194 0.375580413676634 1720 5411856 SGTC_2553 4-methylesculetin 85.09 µM 0.316919236311484 0.352643575671266 no 1195 0.375652442686145 1704 5319502 SGTC_1652 st011932 78 µM 0.31635302864577 0.352856807582796 no 1196 0.375867282596129 1829 1551076 SGTC_2487 5918373 44.05 µM 0.315152302114492 0.353309150064719 no 1197 0.376323009454464 1879 2876279 SGTC_3172 9105863 49.47 µM 0.31484653864158 0.353424371639831 no 1198 0.376439087292612 1790 2348785 SGTC_350 k064-0020 19.8 µM 0.312781691977538 0.35420282392322 no 1199 0.3772232628379 1880 2790705 SGTC_2132 5317594 122.667 µM 0.309772058430785 0.355338554423318 no 1200 0.378367150631373 1807 794577 SGTC_534 k292-0788 63.4 µM 0.309222093276094 0.355546231313759 no 1201 0.378576294452889 1935 4146317 SGTC_2944 9067346 25.62 µM 0.308589839757099 0.35578503479267 no 1202 0.378816775301547 1808 6473075 SGTC_1714 st033236 13.627 µM 0.308256682605094 0.355910891725216 no 1203 0.378943512205491 1857 2916566 SGTC_1802 st050112 57.9 µM 0.305994339376288 0.356765952971475 no 1204 0.379804477862189 1787 4662563 SGTC_2044 5102272 200 µM 0.305548492906445 0.356934547431623 no 1205 0.379974221287579 1765 592666 SGTC_3106 9121286 49.47 µM 0.305273356677883 0.357038602672015 no 1206 0.380078983160642 1857 15943471 SGTC_771 0250-0039 27.3 µM 0.305098207836407 0.357104848688799 no 1207 0.380145678056088 1780 3005115 SGTC_3105 9121040 49.47 µM 0.304306264226846 0.357404436877473 no 1208 0.3804472865824 1884 41448907 SGTC_441 propafenone 146 µM 0.303950126024574 0.357539190790663 no 1209 0.38058294408507 1757 4932 Slows the influx of sodium ions into the cardiac muscle. SGTC_2417 cerulenin 830 nM 0.303539793110172 0.357694472668521 no 1210 0.380739263239141 1761 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1 SGTC_2194 5927483 104.545 µM 0.303321316019617 0.357777160349097 no 1211 0.38082250153882 1815 760979 SGTC_1378 2093-0007 380 nM 0.299185388002715 0.359343752655993 no 1212 0.382399298832791 1757 3618014 SGTC_2178 5812956 200 µM 0.298699807196174 0.359527835046593 no 1213 0.382584552087488 1786 5403383 SGTC_379 3970-0972 5.9 µM 0.298642283687872 0.359549644216044 no 1214 0.382606499581704 1800 2898042 YBL034C STU1 SGTC_2973 9094665 17.96 µM 0.297446294060497 0.360003189157839 no 1215 0.383062902254913 1904 25237061 YIL048W NEO1 SGTC_1612 st002233 45.4 µM 0.295699811200703 0.360665846984498 no 1216 0.383729670690948 1796 1035021 SGTC_1434 4073-0095 163 µM 0.294885938810576 0.360974792961766 no 1217 0.384040506890975 1860 24133745 SGTC_2768 sulfasalazine 50.2 µM 0.294056290282106 0.361289820945802 no 1218 0.384357445145233 1914 5384001 An antioxidant and salicylic acid derivative. SGTC_45 0kpi-0036 14.9 µM 0.292526230159709 0.36187105064253 no 1219 0.384942153863232 1806 2795021 SGTC_1433 4060-0023 7.6 µM 0.292034716162199 0.362057831624291 no 1220 0.385130040340935 1850 3840627 SGTC_246 cycloheximide 667 µM 0.29154730502868 0.362243085916323 no 1221 0.385316385089384 1769 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells. SGTC_1294 1000-1494 117 µM 0.291414472447618 0.362293578267119 no 1222 0.385367173615141 1749 712797 YDL207W GLE1 SGTC_770 0389-1121 67.2 µM 0.290415884041643 0.362673238571194 no 1223 0.385749046692821 1908 6753108 SGTC_930 2810-3379 265 µM 0.290099670103883 0.362793490330711 no 1224 0.385869994085178 1937 1015764 SGTC_2260 7964312 200 µM 0.287687590150518 0.363711215300371 no 1225 0.386792945122064 1919 231951 SGTC_313 3474-0040 5.03 µM 0.286893521852778 0.364013506226485 no 1226 0.387096925449143 1774 1043375 YIL048W NEO1 SGTC_2408 sulbentine 18.36 µM 0.286259648538876 0.364254873876018 no 1227 0.38733963063891 1847 67686 An antifungal agent of unknown mechanism. YDL205C HEM3 SGTC_325 2810-4341 181 µM 0.285986233759497 0.364359001974221 no 1228 0.387444332644758 1915 774970 SGTC_1404 3909-7820 48.3 µM 0.284678726078457 0.364857095384094 no 1229 0.387945145335216 1905 23741373 SGTC_1361 1608-0041 5.61 µM 0.284386157474971 0.36496858029557 no 1230 0.388057233000325 1783 X1361 SGTC_1377 2944-0135 198 µM 0.284210231135658 0.365035623513331 no 1231 0.388124637657613 1815 1894137 SGTC_1332 1480-0653 17.5 µM 0.284041081059016 0.365100088277117 no 1232 0.388189449226511 1945 5749438 SGTC_3130 9127414 49.47 µM 0.282281141298707 0.365771044585649 no 1233 0.388863972446806 1831 1494646 SGTC_1708 st033234 31.827 µM 0.281552103303126 0.366049102191705 no 1234 0.38914348544767 1899 674664 SGTC_646 4092-0839 27.3 µM 0.281471931090705 0.366079684447097 no 1235 0.389174226960018 1904 877796 SGTC_2684 capsaicin 100 µM 0.27958533049721 0.366799586725463 no 1236 0.389897831505032 1839 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_2798 7813637 45.45 µM 0.279457131673486 0.366848522767846 no 1237 0.389947015967788 1853 956368 SGTC_1631 benzylvanillin 81.9 µM 0.279404171056415 0.366868739521061 no 1238 0.389967335229428 1828 75506 SGTC_894 0960-0238 55.9 µM 0.279278357712852 0.366916767959253 no 1239 0.390015606911852 1929 6741907 YDL195W SEC31 SGTC_1585 2',4'-dihydroxychalcone 10.4 µM 0.277778418250956 0.367489520512375 no 1240 0.390591229591742 1926 5357218 A potent inhibitor of glutathione S-transferases. SGTC_282 k297-0036 65.7 µM 0.277257275422399 0.367688588228135 no 1241 0.390791281630397 1870 5061378 SGTC_537 1334-0398 209 µM 0.276529503716639 0.367966644148247 no 1242 0.391070701030659 1963 5846986 SGTC_2059 5238311 157 µM 0.27616625914101 0.368105452996106 no 1243 0.391210185568516 1795 703021 SGTC_1744 st037937 38.9 µM 0.275882863529092 0.368213760636737 no 1244 0.391319018125638 1871 1016152 SGTC_1561 5-methoxyflavone 52.9 µM 0.274927920588112 0.368578796135096 no 1245 0.3916858079351 1938 94525 SGTC_339 3091-4833 71.4 µM 0.274386638761537 0.368785758664072 no 1246 0.391893754931961 1862 3240077 SGTC_2397 5161689 200 µM 0.27345553918271 0.369141859489358 no 1247 0.392251532431117 1882 2259942 SGTC_356 1634-0012 32.5 µM 0.272601721080969 0.369468502610809 no 1248 0.392579694401201 1988 735457 SGTC_3176 9106582 49.47 µM 0.272456283463607 0.369524151727667 no 1249 0.392635600455795 1937 17018027 SGTC_2677 mitomycin C 100 µM 0.271757155579965 0.369791698707847 no 1250 0.392904375319779 1833 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_3022 9087993 49.47 µM 0.270737331252816 0.370182084993569 no 1251 0.393296531255649 1870 17173644 SGTC_298 1391-0729 10 µM 0.268275511836065 0.371125014037043 no 1252 0.394243627134463 1823 3237558 SGTC_1555 citronellol 128 µM 0.268105428432685 0.37119018824391 no 1253 0.394309083734384 1964 8842 A terpine precursor. SGTC_574 1315-0397 40 µM 0.267254455220764 0.37151632785263 no 1254 0.394636625577738 1860 6794277 SGTC_1129 3453-1384 223 µM 0.267136322426255 0.37156161011662 no 1255 0.394682101097195 1863 1084452 SGTC_2508 celastrol 40.54 µM 0.266640265889436 0.371751776229123 no 1256 0.394873074980532 1905 122724 Celastrol is a natural product and antioxidant. SGTC_1030 k029-0042 36.7 µM 0.266399363957431 0.371844138656473 no 1257 0.394965827511411 1843 6080581 SGTC_1243 0416-0003 5.65 µM 0.26595123309373 0.372015972815034 no 1258 0.395138383561282 1812 2141977 SGTC_2465 5809242 33.21 µM 0.264328322008057 0.372638485310066 no 1259 0.395763469158573 1893 2731748 SGTC_835 0312-0010 67.2 µM 0.26432534224804 0.372639628586138 no 1260 0.395764617099565 1834 1626196 SGTC_3225 9130819 49.47 µM 0.262006456983704 0.373529679319223 no 1261 0.396658232044993 1925 4547121 SGTC_2438 5259590 200 µM 0.260707371812738 0.37402859859973 no 1262 0.397159090363658 1940 1201127 SGTC_2163 5671233 125 µM 0.260495543809537 0.374109972099987 no 1263 0.397240776111765 1945 701023 SGTC_628 1636-0253 16 µM 0.259667825744047 0.374427992862786 no 1264 0.397560006414543 1946 4456143 SGTC_1193 1488-0126 41.5 µM 0.258852496393716 0.374741337253997 no 1265 0.397874525785731 1818 1384710 SGTC_276 colchicine 750 µM 0.258327569721885 0.374943118936216 no 1266 0.398077055301664 1876 2833 A microtubule depolymerizer. SGTC_1527 coumarin 137 µM 0.258133106864483 0.375017879104069 no 1267 0.39815209079093 1915 323 A hepatotoxic, DNA x-linker. SGTC_3188 9110789 49.47 µM 0.256525543227819 0.375636077663386 no 1268 0.39877252974512 1964 849217 SGTC_2693 st077581 40.7 µM 0.254369016921101 0.37646588465317 no 1269 0.399605242411241 1961 25238761 SGTC_2827 7993847 71.43 µM 0.253496290851888 0.376801862379633 no 1270 0.399942363529242 1868 2985692 SGTC_97 0535-0701 19.132 µM 0.253395814126871 0.376840549403106 no 1271 0.399981180988429 1802 2832013 YGL099W LSG1 SGTC_1358 1509-0022 2.48 µM 0.251704501356073 0.377491948795499 no 1272 0.40063473871129 1900 3258434 SGTC_451 chloral hydrate 100 µM 0.251007072344483 0.377760661204099 no 1273 0.400904320631441 1890 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1 SGTC_2711 st079103 59.1 µM 0.250489739306932 0.377960022667953 no 1274 0.401104319341169 1964 54693780 SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM 0.250217531461874 0.378064934792789 no 1275 0.401209564124129 1829 2333 A French combination drug. SGTC_860 0443-0016 25.1 µM 0.249196351284686 0.378458589804124 no 1276 0.401604450837295 1995 5337942 SGTC_2266 7929956 200 µM 0.248767204587101 0.378624059351564 no 1277 0.40177043034109 1821 2967153 SGTC_3221 9128209 49.47 µM 0.247276506517315 0.379199012544633 no 1278 0.402347119701823 1859 16460723 SGTC_801 0866-0028 10.1 µM 0.247257701902441 0.379206267080375 no 1279 0.40235439578919 1862 6849771 SGTC_3000 9075062 71.4286 µM 0.24624867962946 0.379595594917758 no 1280 0.402744867277296 1856 17057871 SGTC_806 3966-4455 5.86 µM 0.246152425668102 0.37963274056946 no 1281 0.402782120715437 1810 714982 SGTC_2749 bexarotene 57.39 µM 0.246020365874851 0.379683705963466 no 1282 0.402833233620379 1798 82146 An retinoic acid receptor inhibitor. SGTC_3051 9093778 49.47 µM 0.243134372154078 0.380798008394617 no 1283 0.403950652417831 1952 17217378 SGTC_163 TUB2.036 7.546 µM 0.242654132910415 0.380983528409271 no 1284 0.404136671089282 1991 15992207 YJR013W GPI14 SGTC_614 0462-0418 107 µM 0.24008777128239 0.381975395949503 no 1285 0.405131107053195 1916 5188303 SGTC_733 4069-0007 56.1 µM 0.239289348871632 0.382284134904384 no 1286 0.405440611955995 1916 5717425 YNL287W SEC21 SGTC_3285 9112818 20.8695 µM 0.23827740474279 0.382675547307071 no 1287 0.405832972556311 1898 17017947 YPR165W RHO1 SGTC_2908 7930301 100 µM 0.237343732775869 0.383036790957044 no 1288 0.406195068662251 1889 2223178 SGTC_2142 5622915 118.518 µM 0.237197410790491 0.38309341309829 no 1289 0.406251822448749 1879 5322196 SGTC_1559 coumarin 343 70.1 µM 0.236535381421516 0.383349629454047 no 1290 0.406508627829254 1958 108770 A hepatotoxic, DNA x-linker. SGTC_752 1896-0090 130 µM 0.234902990535792 0.383981609641345 no 1291 0.407142014199056 1868 772567 SGTC_757 1066-0008 322 µM 0.233507529987969 0.38452210701909 no 1292 0.407683661535948 1967 6842497 SGTC_20 0481-0013 4.944 µM 0.232956156408343 0.384735729989999 no 1293 0.40789772563337 1840 182045 SGTC_2068 5226020 147 µM 0.232256118500423 0.385007001562589 no 1294 0.408169546461094 1846 1810509 SGTC_926 2268-1401 59.4 µM 0.230365625493305 0.385739867126096 no 1295 0.408903834878339 2016 2931578 SGTC_1451 4152-0210 104 µM 0.229534442023687 0.386062211710127 no 1296 0.409226777118027 2006 659563 SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM 0.229525069615202 0.386065846910298 no 1297 0.4092304189601 2032 756377 SGTC_1753 st043925 64 µM 0.229069841621653 0.386242424541936 no 1298 0.409407316585065 2017 670181 SGTC_1278 0874-0585 172 µM 0.226993123309074 0.3870482577985 no 1299 0.410214544709476 1942 766306 SGTC_1032 k061-1018 98.7 µM 0.225355589106098 0.387684017205154 no 1300 0.410851328892294 2048 4005393 SGTC_802 4112-3352 742 µM 0.224538143545787 0.388001496665042 no 1301 0.4111692951285 1997 704594 SGTC_1514 1189-1591 158 µM 0.2209443975279 0.389398121000636 no 1302 0.412567863660042 1995 767698 YMR146C TIF34 SGTC_1575 cyproterone acetate 48 µM 0.219794241054832 0.389845404995155 no 1303 0.413015702471379 1857 9880 An androgen receptor antagonist and liver toxin. SGTC_306 1672-3436 11.6 µM 0.21927614292613 0.390046935719585 no 1304 0.413217472437689 1966 6797378 SGTC_805 3852-0218 479 µM 0.218564448529447 0.390323820040207 no 1305 0.413494674581168 1862 6615355 SGTC_1075 aripiprazole 15.2 µM 0.217481179610775 0.390745371984293 no 1306 0.413916686252862 1890 60795 An atypical antipschotic. YIL048W NEO1 SGTC_2168 5727979 200 µM 0.21702267094518 0.390923838433588 no 1307 0.414095338551363 1977 695210 SGTC_525 k781-2675 26.7 µM 0.216792055013673 0.391013610322739 no 1308 0.414185201952775 2050 3651118 YDL195W SEC31 SGTC_152 4469-0003 551.229 µM 0.21636972400843 0.391178026212896 no 1309 0.414349782022536 2061 697280 SGTC_1826 st055655 41.6 µM 0.21626319592113 0.391219501282914 no 1310 0.414391297808592 1920 676168 SGTC_2374 9071832 200 µM 0.215125533773766 0.391662509572853 no 1311 0.414834723427423 2034 17381698 SGTC_632 0781-2353 4.65 µM 0.214950262345342 0.39173077318246 no 1312 0.414903048487335 1968 6811515 YHR007C ERG11 SGTC_1277 0873-0036 22 µM 0.213488246694334 0.392300319501227 no 1313 0.415473077798597 1992 5965735 SGTC_2239 6685329 187.64 µM 0.213291094104692 0.392377140421819 no 1314 0.415549959806767 1885 805680 SGTC_2697 mebhydrolin 72.4 µM 0.212915358174289 0.392523558327137 no 1315 0.415696491472372 2027 22530 H1 Histamine receptor antagonist. YIL048W NEO1 SGTC_2634 4'-methoxyflavone 100 µM 0.21209732969708 0.39284238271065 no 1316 0.416015551454315 1888 77793 From seeds of Psoralea corylifolia (Fabaceae) SGTC_423 5-fluorouracil 457 µM 0.2111797983143 0.393200073633947 no 1317 0.416373486944951 1795 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_211 3455-0679 143.504 µM 0.211086794291842 0.393236335410196 no 1318 0.416409772349305 1922 748649 SGTC_98 0074-0023 107.663 µM 0.210988953280022 0.39327448410277 no 1319 0.416447945667967 1877 3563821 SGTC_64 000l-0018 272.079 µM 0.210830448496118 0.39333628807363 no 1320 0.416509789031275 1861 6811119 SGTC_2805 7950783 58.44 µM 0.210468938842878 0.393477257482628 no 1321 0.416650845960097 1939 1178958 YDL195W SEC31 SGTC_1679 SEC14.276 6.7 µM 0.209998394408718 0.393660765533662 no 1322 0.41683446308662 2061 1005053 YMR079W SEC14 SGTC_2382 9035899 200 µM 0.209047059112235 0.394031849762051 no 1323 0.417205751114611 1902 6462679 SGTC_853 0419-0306 21 µM 0.208879040065877 0.394097398406293 no 1324 0.417271333427026 1887 762713 SGTC_197 4544-0043 41.561 µM 0.208298557810934 0.394323882859025 no 1325 0.417497928825586 2039 896523 SGTC_3058 9093861 49.47 µM 0.207164774053106 0.394766349750199 no 1326 0.417940588377779 1996 17217477 SGTC_2997 9067075 71.4286 µM 0.206648360045248 0.394967928899498 no 1327 0.418142244741084 1968 27209819 SGTC_2855 9016525 58.44 µM 0.20423870027124 0.395908896188959 no 1328 0.419083485119509 1986 43811474 SGTC_2190 6049624 200 µM 0.203650365744064 0.396138732027314 no 1329 0.419313365819024 2010 2265554 SGTC_2822 7994718 71.43 µM 0.203390570678125 0.396240233771686 no 1330 0.419414884647743 2008 1018011 SGTC_737 1950-0117 57.9 µM 0.202212083414799 0.396700756120465 no 1331 0.419875463529525 2070 5393513 SGTC_895 0964-0006 13.7 µM 0.201406023192151 0.397015826653376 no 1332 0.420190552943195 2053 6738897 SGTC_1495 4469-0029 237 µM 0.200190657119806 0.397491012540308 no 1333 0.420665736909022 1924 793680 SGTC_3220 9131269 49.47 µM 0.199582789530103 0.397728734770555 no 1334 0.420903444469125 2025 17722206 SGTC_2240 6690706 185.951 µM 0.198376152618605 0.398200733566659 no 1335 0.42137538706083 1835 805876 SGTC_878 0828-0289 13.7 µM 0.197385399211755 0.398588396885742 no 1336 0.421762977300202 1908 745350 YLR208W SEC13 SGTC_3354 9151612 71.43 µM 0.195817027828007 0.399202275825439 no 1337 0.422376690903036 2052 27261949 SGTC_2053 5265679 138 µM 0.194829319158366 0.399589004637905 no 1338 0.422763284360023 1958 764595 SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM 0.194088884462046 0.39987898010068 no 1339 0.423053142524366 1933 6708514 SGTC_2847 9005661 71.43 µM 0.193883006058502 0.399959617806747 no 1340 0.423133745205373 2085 2991449 SGTC_2736 butenafine 14.65 µM 0.193302780326391 0.400186901459442 no 1341 0.423360924504628 2055 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_874 0599-0792 117 µM 0.190168405372621 0.401415268794279 no 1342 0.424588584090551 2106 765305 SGTC_2003 4023581 200 µM 0.189107176994676 0.40183138768746 no 1343 0.425004408275633 1938 16641307 SGTC_619 1652-1634 108 µM 0.187701216531713 0.402382851047334 no 1344 0.42555543828351 1938 5400454 SGTC_1225 1216-0074 20.6 µM 0.187396406051568 0.402502433287917 no 1345 0.425674920123313 1950 4241466 SGTC_104 0074-0074 590.992 µM 0.183669764315204 0.403965191477753 no 1346 0.427136264962585 2093 3943124 SGTC_2945 9067681 61.76 µM 0.183112739281202 0.404183947422089 no 1347 0.427354780137371 2067 16456930 SGTC_1701 st028638 40.4 µM 0.179723738105249 0.405515525840972 no 1348 0.428684728285283 2067 3490878 SGTC_922 1866-0035 480 µM 0.179605563674255 0.405561977796574 no 1349 0.428731118267461 1949 3156169 SGTC_2253 7938677 135.83 µM 0.178810336270023 0.405874600008101 no 1350 0.429043314460316 2109 2301972 SGTC_2405 ticlatone 3.52 µM 0.177058195440232 0.406563618527568 no 1351 0.429731339128365 2057 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W SGTC_332 4112-0506 40.9 µM 0.176238786978007 0.406885945269623 no 1352 0.430053175028062 1987 2790355 SGTC_1079 idarubicin 2.36 µM 0.174540212991709 0.407554305783834 no 1353 0.430720465177756 2123 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_873 0591-4978 488 µM 0.174509225869616 0.407566501205234 no 1354 0.430732640409823 2125 3305145 SGTC_2926 9010726 65.15 µM 0.173908198950829 0.407803061579219 no 1355 0.430968804494618 1935 2994293 SGTC_429 1112-0049 25.5 µM 0.17317683083126 0.408090968757507 no 1356 0.431256217395095 1906 2836170 SGTC_218 alverine citrate 93.75 µM 0.172507860415386 0.408354356191863 no 1357 0.431519141140372 2088 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_2561 acetosyringone 100 µM 0.172010246979559 0.408550303716176 no 1358 0.431714736573305 2144 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent. SGTC_3348 9149464 3.537 µM 0.171533481327183 0.408738063361677 no 1359 0.431902153135792 2117 1951442 SGTC_749 1000-0129 128 µM 0.168747003555901 0.409835850487106 no 1360 0.432997822701908 2116 708470 SGTC_2865 9030313 51.95 µM 0.168491926798413 0.409936378397313 no 1361 0.433098147179779 1918 42562754 SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM 0.166245793866567 0.410821853279002 no 1362 0.433981761266956 2077 4620898 SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM 0.165079755806376 0.41128171063143 no 1363 0.434440603458773 2026 521171 SGTC_2490 carminic acid 95.39 µM 0.165078149984335 0.411282344013215 no 1364 0.43444123541935 2034 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_685 1278-0033 54.9 µM 0.164970438242637 0.411324829108767 no 1365 0.434483625040921 2089 3590572 SGTC_266 formosanin C 406 nM 0.164750648710964 0.411411524640084 no 1366 0.434570124864957 2107 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1 SGTC_2624 nerol 100 µM 0.164369251419255 0.411561976285927 no 1367 0.434720234070257 2058 637566 A natural product oil. SGTC_3129 9127257 49.47 µM 0.163016123716204 0.412095855925178 no 1368 0.43525286979827 1874 837894 SGTC_2306 7482397 179.52 µM 0.1627323993802 0.412207820683518 no 1369 0.435364567995873 2101 891448 SGTC_2350 9023895 38.85 µM 0.161837958501859 0.412560836280608 no 1370 0.435716730243728 2057 2997209 SGTC_765 1319-0117 244 µM 0.159536190833927 0.413469616558146 no 1371 0.43662322363679 2133 3487746 YGL099W LSG1 SGTC_3074 9116018 49.47 µM 0.158187799031274 0.414002202206263 no 1372 0.437154408833567 2026 17027303 SGTC_2811 7967822 32.47 µM 0.157542550434432 0.414257117496776 no 1373 0.43740863808056 2072 2232244 SGTC_2898 9056270 58.44 µM 0.156815553409559 0.414544372024023 no 1374 0.437695107331355 2051 19154699 SGTC_132 0417-1715 25.805 µM 0.155030440237349 0.415249908053263 no 1375 0.438398659789244 2159 6769098 SGTC_1285 0929-0069 65.5 µM 0.154942530944682 0.415284659807407 no 1376 0.438433311828567 2017 1206237 SGTC_1842 st055362 61.2 µM 0.15473103887217 0.415368268251166 no 1377 0.438516679597045 2031 676032 SGTC_1016 4226-1401 38 µM 0.153919795815448 0.415689009727851 no 1378 0.438836487650237 2132 2901613 SGTC_1992 st073643 23.3 µM 0.153240997184427 0.415957429779453 no 1379 0.439104114188722 2114 3161292 SGTC_2297 7971671 152.32 µM 0.153052058947253 0.416032149361709 no 1380 0.439178610879851 2104 909016 SGTC_3306 9127676 59.7925 µM 0.152117251449777 0.4164018831698 no 1381 0.439547228930832 1991 41905287 SGTC_2367 9070478 135.38 µM 0.151768686960939 0.416539765882444 no 1382 0.439684690088686 2041 572802 SGTC_1270 0831-1170 17.3 µM 0.151416834132041 0.416678959789277 no 1383 0.439823455423497 2117 6764716 SGTC_1179 1021-1431 9.29 µM 0.150581390701214 0.417009505236403 no 1384 0.440152971028075 2065 2840958 SGTC_1621 st003705 32.4 µM 0.149225294209474 0.417546173290118 no 1385 0.440687930778342 2151 24207032 SGTC_549 1661-1316 519 µM 0.148715903433763 0.417747801753925 no 1386 0.440888905832322 2155 2857282 SGTC_718 1130-0073 349 µM 0.148603312218496 0.417792370839663 no 1387 0.440933329630564 2089 6740020 SGTC_335 4077-0256 27.6 µM 0.148049110748462 0.418011766148741 no 1388 0.441152005242292 2121 3121989 SGTC_2954 9074818 52.69 µM 0.147422948830276 0.418259679603077 no 1389 0.441399096436663 2065 16648742 SGTC_3103 9120822 49.47 µM 0.146999069170105 0.418427522799145 no 1390 0.441566377517022 2134 17141819 SGTC_3006 9075424 71.4286 µM 0.146241766261381 0.418727428214058 no 1391 0.441865267628887 2013 7465181 SGTC_1910 st062352 60.4 µM 0.145724821982462 0.418932174479853 no 1392 0.442069312716227 2076 2245730 SGTC_1175 0741-0056 27.6 µM 0.145639814620466 0.418965845473475 no 1393 0.442102867775902 2121 765927 SGTC_2333 9017922 200 µM 0.144969223249578 0.419231484173801 no 1394 0.442367585671235 2135 3163164 SGTC_1938 st074717 56.4 µM 0.144821427612464 0.419290034829323 no 1395 0.442425931894288 2131 17250979 SGTC_2540 epiandrosterone 100 µM 0.143831432662436 0.419682276819906 no 1396 0.44281679063186 2198 441302 A steroid. SGTC_544 k015-0020 52.4 µM 0.14320921457674 0.419928844260722 no 1397 0.443062476327917 2041 3008304 SGTC_1092 toremifene 6.32 µM 0.143063937999353 0.419986417792069 no 1398 0.4431198426141 2179 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_1316 1272-0050 65.9 µM 0.137579310083137 0.422161233727265 no 1399 0.445286454086924 2123 7340392 SGTC_259 usnic acid 108.925 µM 0.137544943960592 0.422174868461656 no 1400 0.445300035077548 2138 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_1949 st076024 69.1 µM 0.137496017708744 0.422194280077785 no 1401 0.445319370129759 2148 2921930 SGTC_57 miconazole 162.5 nM 0.137425688560497 0.422222183679146 no 1402 0.445347163570908 2116 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_2106 5357045 167.29 µM 0.137369750341888 0.422244377853197 no 1403 0.445369270039068 2125 668842 SGTC_1265 0819-1001 68.8 µM 0.135856996945236 0.422844674707803 no 1404 0.445967165830618 2151 3106768 SGTC_2790 5423970 71.43 µM 0.13567020056248 0.422918812454148 no 1405 0.446041003184177 2144 1376240 YKL165C | YIL048W MCD4 | NEO1 SGTC_753 1322-0200 289 µM 0.135432235685359 0.423013262453635 no 1406 0.44613506926152 2092 5403907 SGTC_1746 st038117 42 µM 0.135047338660457 0.423166040261735 no 1407 0.446287223143691 2056 2898218 SGTC_1336 1486-0901 104 µM 0.134644446710268 0.423325973202218 no 1408 0.446446499082953 2079 5006114 SGTC_3192 9110362 49.47 µM 0.132877392192045 0.424027576224905 no 1409 0.447145173376205 2145 16649480 SGTC_1166 k206-0078 225 µM 0.132830077421802 0.424046365715331 no 1410 0.447163883390855 2127 5404595 SGTC_978 1416-0512 87.4 µM 0.130861411483456 0.424828308587898 no 1411 0.447942470642518 2068 6814003 SGTC_641 4092-0595 30 µM 0.130132678865219 0.425117832222481 no 1412 0.448230727973501 2137 786260 SGTC_2866 9034245 58.44 µM 0.129294191989106 0.425451010914089 no 1413 0.448562433491009 2208 6462273 SGTC_1335 1486-0900 202 µM 0.129127254866793 0.425517350923428 no 1414 0.448628478138374 2191 X1335 SGTC_1140 3229-1848 2.98 µM 0.128194624805134 0.425888012369033 no 1415 0.448997476878793 2166 2849525 SGTC_3118 9124250 49.47 µM 0.127341327542857 0.426227201428288 no 1416 0.449335125943574 2077 1504786 SGTC_2345 9052315 157.45 µM 0.124150528017521 0.427496038608195 no 1417 0.45059804600709 2060 6469265 SGTC_1116 jasmonic acid  1.58368 µM 0.123654800155972 0.427693234908749 no 1418 0.45079430057484 2160 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid. SGTC_1756 st041558 35.5 µM 0.12309510149995 0.427915899952017 no 1419 0.451015895109025 2225 3955792 SGTC_443 clozapine 122 µM 0.122275655816326 0.428241941605416 no 1420 0.451340355576987 2210 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_2738 aclarubicin 5.55 µM 0.121290388518001 0.428634025332015 no 1421 0.451730516332539 2152 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31 SGTC_1058 3448-5425 97.3 µM 0.120586164732709 0.428914311954359 no 1422 0.452009413906372 2172 7279705 SGTC_2089 5281248 129.67 µM 0.120419556946055 0.428980628417297 no 1423 0.452075399963441 2110 2737878 SGTC_2875 9039966 71.43 µM 0.119831720380284 0.429214626532794 no 1424 0.452308226879497 2157 6463691 SGTC_81 0411-0046 9.971 µM 0.119192151472197 0.429469245821812 no 1425 0.452561562270475 2145 12925265 SGTC_2421 5690543 90.72 µM 0.118888973619393 0.429589954457637 no 1426 0.452681658789118 2097 3397993 SGTC_1696 st025591 34.7925 µM 0.118580109661237 0.429712933755087 no 1427 0.45280401217121 2187 2787147 SGTC_2937 9044753 11.33 µM 0.118151997643598 0.429883404917693 no 1428 0.45297361189296 2177 6465530 YGL099W LSG1 SGTC_2223 6903751 107.57 µM 0.117012547070357 0.43033718965392 no 1429 0.453425055331281 2159 5598863 SGTC_244 nsc-207895 1.295 µM 0.116957900318827 0.430358954970058 no 1430 0.453446707561616 2164 42640 SGTC_2864 9034755 47.6 µM 0.116757646265254 0.430438716190172 no 1431 0.453526053751074 2231 4930451 SGTC_1466 k213-0079 57.5 µM 0.116217720844319 0.430653782700864 no 1432 0.453739996357599 2111 3657981 SGTC_322 k048-0136 19.3 µM 0.115356354446314 0.430996930173708 no 1433 0.454081336027365 2141 6823282 SGTC_304 1310-0298 97 µM 0.11445768735426 0.431354992864996 no 1434 0.454437493253065 2127 1550234 SGTC_2826 7992541 19.48 µM 0.113683380864247 0.431663550884968 no 1435 0.454744393625726 2224 2985066 SGTC_1690 st023502 41.2 µM 0.111529921141669 0.43252191460019 no 1436 0.455598069982116 2214 24207482 SGTC_2929 9013348 24.6 µM 0.110454180882452 0.432950821570858 no 1437 0.456024592907682 2130 2995952 SGTC_2356 9061756 188.97 µM 0.109803184295672 0.433210417957446 no 1438 0.456282732807455 2198 20104043 SGTC_1581 himbacine 57.9 µM 0.108797621414136 0.43361146052065 no 1439 0.456681505228551 2058 5281825 An alkaloid muscarinic receptor antagonist. SGTC_2277 7947813 106.88 µM 0.106397272463148 0.434569052780467 no 1440 0.457633578527215 2197 1246798 SGTC_512 prima-1 270 µM 0.105770757728103 0.434819057219863 no 1441 0.457882119281984 2194 322968 A re-activator of the apoptotic function of mutant p53. SGTC_474 dl-dihydrosphingosine 5 µM 0.105086123400474 0.435092283500579 no 1442 0.458153735127917 2195 3058739 A sphingolipid protein kinase C inhibitor. SGTC_1296 1068-0102 11.9 µM 0.104431428446234 0.435353590464407 no 1443 0.458413491369011 2188 767053 SGTC_169 k015-0017 16.025 µM 0.104012368926261 0.435520863599046 no 1444 0.458579766414833 2192 1840002 SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM 0.104006994436737 0.435523008972423 no 1445 0.458581898959737 2214 279621 SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM 0.10236157764048 0.436179910676426 no 1446 0.459234840016192 2075 688788 SGTC_3099 9120367 49.47 µM 0.10205978092629 0.436300416500547 no 1447 0.459354612216806 2226 24824940 SGTC_2536 dehydroabietamide 32.04 µM 0.101747195254018 0.436425236531835 no 1448 0.45947867005392 2208 3983547 SGTC_3115 9123671 49.47 µM 0.101519144569407 0.436516304500966 no 1449 0.459569180450117 2246 3286988 SGTC_2605 digitonin 300 nM 0.10070731268266 0.436840522348124 no 1450 0.459891403104496 2236 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_3260 9137109 49.47 µM 0.0989433508138823 0.437545134259501 no 1451 0.460591624391938 2231 17478346 SGTC_3141 9094609 49.47 µM 0.0987706475011397 0.437614131021122 no 1452 0.46066018720331 2046 25236309 YDL196W YDL196W SGTC_692 k241-0027 77.8 µM 0.0983660458724422 0.437775780985452 no 1453 0.460820817679926 2214 3600480 SGTC_1064 honokiol 6.76 µM 0.097908510519326 0.437958592002866 no 1454 0.461002471021064 2124 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis. SGTC_100 0086-0128 49.5915 µM 0.097518967452304 0.438114246729144 no 1455 0.461157136085207 2093 93297 SGTC_2880 9042983 58.44 µM 0.0966289246354495 0.438469928462467 no 1456 0.461510542718271 2149 6464714 SGTC_837 0091-0265 12.5 µM 0.0958315902856934 0.438788603960168 no 1457 0.461827163697851 2109 759367 SGTC_2650 prasterone 100 µM 0.0946656346105783 0.439254679989232 no 1458 0.46229020748083 2237 16759247 A steroid and weak partial agonist of the androgen receptor. SGTC_1675 st018485 24.5 µM 0.0936998060350418 0.439640821551635 no 1459 0.46267381218122 2106 3323024 SGTC_1488 4013-0813 75.9 µM 0.0930486336227861 0.439901194941757 no 1460 0.462932462369954 2123 2910057 SGTC_212 3807-4682 38.772 µM 0.092256393215765 0.440218009867034 no 1461 0.463247166864735 2207 3125501 YBL034C STU1 SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM 0.091994463078561 0.440322763493056 no 1462 0.463351219380713 2180 2724278 An inhibitor of dopamine biosynthesis. SGTC_2139 5578692 56.4705 µM 0.091572077633457 0.440491696748834 no 1463 0.463519018517421 2260 650991 YMR113W FOL3 SGTC_255 tunicamycin 200.472 nM 0.0905129998240541 0.440915322975077 no 1464 0.463939781995421 2242 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_2769 toremifene 3.73 µM 0.0903567264922426 0.440977837321772 no 1465 0.464001871616005 2211 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_3077 9117319 49.47 µM 0.0896556051272082 0.441258326442792 no 1466 0.464280447889637 2266 17154678 SGTC_1204 4049-0315 18.3 µM 0.0881673188735434 0.441853824562771 no 1467 0.464871845947153 2201 588402 SGTC_2700 st077718 96.8 µM 0.0877373348678 0.442025895747498 no 1468 0.465042722548304 2139 904970 SGTC_383 2324-0395 7.37 µM 0.0871296495147342 0.442269098182371 no 1469 0.465284229046495 2209 3146421 SGTC_2993 9054257 71.4286 µM 0.085137452729695 0.44306654960827 no 1470 0.4660760577059 2254 6470217 YGL055W OLE1 SGTC_106 0092-0003 11.579 µM 0.0851269881605841 0.443070739056081 no 1471 0.466080217364069 2257 1072148 SGTC_35 0133-0054 64.071 µM 0.0850492507819767 0.443101861099607 no 1472 0.466111118028224 2183 99677 SGTC_388 3',4'-dichloroisocoumarin 16.7 µM 0.084701569828085 0.443241058943908 no 1473 0.466249323956153 2169 1609 A potent and irreversible inhibitor of serine proteases. SGTC_504 lovastatin 124 µM 0.0845454856483611 0.443303551218932 no 1474 0.466311369976315 2088 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1 SGTC_879 0831-1030 162 µM 0.084191848278533 0.443445144157704 no 1475 0.466451949654805 2247 1549252 SGTC_1450 4112-4260 37.6 µM 0.0830222103985693 0.443913507048993 no 1476 0.46691693961673 2255 1633175 SGTC_2691 st077356 60.2 µM 0.0829234691179431 0.443953050020134 no 1477 0.466956196324285 2227 2839272 SGTC_2242 6630449 61.2675 µM 0.0816027332467022 0.444482019282544 no 1478 0.467481313864763 2190 691249 YDR170C SEC7 SGTC_1522 st012842 45.6 µM 0.0807771331828597 0.44481273149453 no 1479 0.467809596853848 2241 3491067 YOR116C RPO31 SGTC_2492 derrusnin 100 µM 0.0790742536302523 0.445494978335183 no 1480 0.468486781000656 2194 1715307 Part of coumarin class of compounds. SGTC_3190 9110366 49.47 µM 0.0768458793201631 0.446388004553878 no 1481 0.4693730761004 2274 17123768 SGTC_1373 2887-0003 58.5 µM 0.0752943450673393 0.447009946423002 no 1482 0.469990260347482 2206 776948 SGTC_2299 7976368 114.88 µM 0.0751619033636631 0.447063042538821 no 1483 0.470042947645759 2251 2979718 SGTC_1393 3470-5649 58.2 µM 0.074165349209714 0.447462593246179 no 1484 0.470439408607639 2207 4108395 SGTC_2975 9084847 53.72 µM 0.0735532303032024 0.447708037921703 no 1485 0.470682943544293 2119 27211724 SGTC_2840 9008771 71.43 µM 0.0725043094789703 0.448128675963225 no 1486 0.471100288014632 2269 2992978 SGTC_653 0203-0016 55.2 µM 0.071857904369632 0.448387926304613 no 1487 0.471357495425311 2224 295302 SGTC_1970 st070122 35.8 µM 0.0710352846899029 0.448717881970792 no 1488 0.471684836644345 2247 102928 SGTC_688 0527-0193 473 µM 0.0703008795858244 0.449012484437182 no 1489 0.471977091216471 2217 4007154 SGTC_1143 3454-2408 5.08 µM 0.0700026731205907 0.449132116313645 no 1490 0.472095766008287 2285 X1143 SGTC_1864 st057645 30.4 µM 0.069233617587244 0.449440660640302 no 1491 0.472401832166258 2290 688666 SGTC_503 tyrphostin 8 294 µM 0.067537705728974 0.45012116659903 no 1492 0.473076822852623 2286 92970 A tyrosine kinase inhibitor. YOR207C RET1 SGTC_3210 9128157 49.47 µM 0.0675113450653552 0.450131745309688 no 1493 0.473087315288139 2049 17590849 SGTC_393 acivicin 6.25 µM 0.0673773299282714 0.450185527028563 no 1494 0.473140658133096 2225 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1 SGTC_3286 9117135 37.221 µM 0.0653887154031622 0.450983686446923 no 1495 0.473932254327787 2218 3438150 SGTC_1182 1222-0449 220 µM 0.0648246179040632 0.451210131430436 no 1496 0.474156820209049 2232 658318 SGTC_2208 7283366 200 µM 0.0635079356653247 0.451738747265432 no 1497 0.474681020127524 2278 898663 SGTC_2785 7756463 72.73 µM 0.06348122859179 0.451749470393385 no 1498 0.474691653252674 2265 2201551 SGTC_1059 3448-6867 171 µM 0.0631885907518411 0.451866969397661 no 1499 0.474808164942661 2315 3934407 SGTC_995 3931-2021 34.6 µM 0.0631107422666105 0.451898227581508 no 1500 0.474839160130669 2224 730143 SGTC_73 0327-0325 16.231 µM 0.0631093366588761 0.451898791972173 no 1501 0.474839719771423 2312 53298 SGTC_1928 4'-methoxychalcone 40.3 µM 0.0628030026808155 0.452021795916072 no 1502 0.474961687398976 2308 641818 SGTC_598 3937-0236 20.2 µM 0.0627575550694142 0.452040045134616 no 1503 0.474979782677511 2255 1379313 SGTC_2218 6965428 192.983 µM 0.0617965131248099 0.452425969489433 no 1504 0.475362440152869 2265 675684 SGTC_1742 st038235 28.8875 µM 0.0615717231710024 0.452516244596773 no 1505 0.475451947921963 2219 564103 YBR002C RER2 SGTC_2286 7945697 125 µM 0.0610432504796019 0.452728487625291 no 1506 0.475662382178385 2233 1245733 SGTC_2588 indole-3-carbinol 100 µM 0.0595998006830517 0.453308268647787 no 1507 0.476237188560075 2295 3712 Induces cell cycle arrest. SGTC_489 paxilline 115 µM 0.0588727001185442 0.453600356144009 no 1508 0.476526751237005 2194 105008 A toxic potassium channel blocker. SGTC_1669 st015249 58.4 µM 0.0588414755994502 0.453612900077509 no 1509 0.47653918646041 2308 722793 SGTC_1511 0906-3109 28.5 µM 0.0576920988935771 0.454074675238433 no 1510 0.476996943692307 2305 2882180 SGTC_660 4031-1742 102 µM 0.0560467563040896 0.454735818232624 no 1511 0.477652279764303 2282 6738706 SGTC_2658 polymyxin b sulfate 77.05 µM 0.0552571951592114 0.45505312982331 no 1512 0.477966781673906 2277 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides.  YIL048W NEO1 SGTC_2952 9073731 13.78 µM 0.0550107421858824 0.455152181087722 no 1513 0.478064952863246 2268 16457353 SGTC_369 0957-0393 4.5 µM 0.0542634515663534 0.45545253970895 no 1514 0.478362634027699 2259 6997992 SGTC_2073 5212005 126 µM 0.0532562232490097 0.455857415385705 no 1515 0.478763879729289 2315 691789 SGTC_2310 7668677 200 µM 0.0530658485387096 0.455933945492868 no 1516 0.478839721007125 2277 2197143 SGTC_2360 9040895 200 µM 0.0530152460274324 0.455954287837649 no 1517 0.478859880111611 2253 4914414 SGTC_630 4356-0227 183 µM 0.0512277252550544 0.456672949654276 no 1518 0.479572029642604 2308 779312 SGTC_2740 felodipine 17.08 µM 0.0511746633258796 0.456694285056821 no 1519 0.479593170560343 2324 3333 L-type calcium channel blocker SGTC_2120 5538279 151.968 µM 0.0510340606291081 0.456750819887059 no 1520 0.479649189721611 2288 2058197 SGTC_1869 3',7'-dimethoxyflavone 40.3 µM 0.0487595579710738 0.457665493737371 no 1521 0.480555455939508 2298 688664 SGTC_1877 wortmannin 25 µM 0.0481049937006348 0.457928763523648 no 1522 0.480816283208762 2322 312145 A covalent inhibitor of PI 3-kinase. SGTC_928 2764-0428 58.7 µM 0.0468886178812444 0.458418046317986 no 1523 0.481300999866214 2244 662578 SGTC_189 3970-0742 2.116 µM 0.0456621400411098 0.458911456409956 no 1524 0.481789770092856 2331 2891807 SGTC_1732 st034308 51.822 µM 0.045514218430109 0.458970969332745 no 1525 0.481848720987482 2304 830119 SGTC_2720 fluspirilene 36.88 µM 0.0449742286796808 0.459188229821133 no 1526 0.482063925348596 2315 3396 An atypical antipsychotic. SGTC_2332 7982454 138.89 µM 0.0446675173689554 0.459311638057076 no 1527 0.482186162614285 2322 2981748 SGTC_1801 st050089 28.441 µM 0.0446038749120267 0.459337245701263 no 1528 0.482211527001279 2319 5008493 YIL048W | YNL267W NEO1 | PIK1 SGTC_1173 0443-0020 122 µM 0.0442734638908886 0.459470195004201 no 1529 0.482343211837408 2280 5331295 SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM 0.0431646424246576 0.459916390649569 no 1530 0.482785145031464 2318 803109 SGTC_635 k038-0028 24.7 µM 0.0426212639068136 0.460135067517666 no 1531 0.483001722372084 2287 4035102 SGTC_1996 st072960 66.8 µM 0.0424152004490581 0.460217998707647 no 1532 0.483083855523962 2348 1719405 SGTC_3166 9102297 49.47 µM 0.0417998161395598 0.460465673251491 no 1533 0.48332914079286 2280 25237072 SGTC_1632 st005650 90 µM 0.0410695991574362 0.460759584546016 no 1534 0.48362020525234 2289 2759605 SGTC_907 3448-6986 75.5 µM 0.0407293331085254 0.460896548477797 no 1535 0.48375583827655 2327 590582 SGTC_1107 amlodipine 47 µM 0.0396956432295906 0.461312657839197 no 1536 0.484167887570073 2306 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.  SGTC_1255 0566-0045 221 µM 0.0396685657184392 0.461323558397136 no 1537 0.48417868143239 2283 2788469 SGTC_944 3370-0224 231 µM 0.0391881171337849 0.461516976774263 no 1538 0.484370203756915 2317 4580514 SGTC_728 3030-5151 22.5 µM 0.0391258788998412 0.461542033229861 no 1539 0.484395014192042 2329 3125388 SGTC_3349 9149703 23.001 µM 0.0337149425604141 0.463720991764218 no 1540 0.486552231653374 2355 4910494 SGTC_2601 securinine 100 µM 0.033143079098359 0.463951343232407 no 1541 0.486780244726136 2322 442872 A GABA receptor antagonist. SGTC_1060 3448-7350 82 µM 0.0331018925844536 0.463967933978089 no 1542 0.486796666757146 2337 570178 SGTC_258 haloperidol 50.781 µM 0.0329568877453086 0.464026345305232 no 1543 0.486854483772225 2322 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_394 menadione 8.33 µM 0.032939864327442 0.464033202785398 no 1544 0.486861271448034 2355 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_1907 st060210 83.7 µM 0.0313835029385378 0.464660190945961 no 1545 0.487481848709581 2330 688793 SGTC_90 0870-0863 4.608 µM 0.0312514576326316 0.464713390134593 no 1546 0.487534501338222 2341 1738164 SGTC_88 0180-0332 8.668 µM 0.0305643540018149 0.464990224641704 no 1547 0.487808485122757 2360 3101745 SGTC_2455 5377712 9.75 µM 0.0301333298726467 0.465163893206235 no 1548 0.487980359699467 2230 2243908 SGTC_2346 9031566 143.75 µM 0.0282020003289696 0.465942146961395 no 1549 0.488750520914133 2339 4771086 SGTC_2460 5552655 174.22 µM 0.0260981029714993 0.46679008725122 no 1550 0.489589545079002 2228 5401989 SGTC_2328 6201408 200 µM 0.0258769277476751 0.466879237012469 no 1551 0.489677751436829 2332 2890418 SGTC_2365 9042475 200 µM 0.0253441424360226 0.467093995200658 no 1552 0.489890232327029 2334 6464479 SGTC_426 0988-0037 14.6 µM 0.0249035670813315 0.46727159210437 no 1553 0.490065940999179 2362 5383008 SGTC_2683 piperine 63.03 µM 0.0241538871769821 0.467573804695245 no 1554 0.490364930044618 2356 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_896 0964-0007 44.5 µM 0.023995505826477 0.467637654126564 no 1555 0.490428096753614 2366 6756758 SGTC_962 1254-0300 21.5 µM 0.0213559630264961 0.468701873616062 no 1556 0.49148085097984 2357 7340576 SGTC_2109 5483026 200 µM 0.0211499770436923 0.468784933224657 no 1557 0.491563008940397 2340 759335 SGTC_2630 antimycin a 100 µM 0.0208438257322782 0.468908384949931 no 1558 0.491685118722015 2365 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain. SGTC_2610 ononetin 44.17 µM 0.0199411159588552 0.469272408845687 no 1559 0.492045172932771 2342 259632 SGTC_2832 7992762 51.95 µM 0.019941078417328 0.469272423985101 no 1560 0.492045187906696 2362 2985177 SGTC_3254 9136651 49.47 µM 0.0198656896290695 0.469302826196535 no 1561 0.492075257725204 2374 16454030 SGTC_587 k089-0003 57 µM 0.0198607311155615 0.469304825834049 no 1562 0.49207723549569 2362 9659696 SGTC_3048 9093155 49.47 µM 0.0177998735541119 0.47013598167905 no 1563 0.492899252816908 2382 25236002 SGTC_2526 patulin 37.61 µM 0.016272009386394 0.470752262389248 no 1564 0.493508693929429 2351 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.  SGTC_1850 st056238 17 µM 0.0160063203790416 0.470859438145769 no 1565 0.493614674704143 2375 5393177 SGTC_2545 solidagenone 89.61 µM 0.014676836138371 0.471395767681616 no 1566 0.494144999726434 2378 6708572 An anti ulcer agent SGTC_60 0986-0278 202 µM 0.014608032209271 0.47142352541389 no 1567 0.494172445580439 2344 3110598 SGTC_1740 st038286 13.222 µM 0.0145602643825954 0.47144279658313 no 1568 0.494191500159603 2361 716786 SGTC_1003 4049-0218 100 µM 0.0123569446085944 0.472331762807499 no 1569 0.495070417792376 2369 295161 SGTC_3055 9094636 49.47 µM 0.0111845876258253 0.472804826312653 no 1570 0.495538088134542 2378 25236176 SGTC_3284 9108171 64.8615 µM 0.0101423067407836 0.473225434408502 no 1571 0.495953874388806 2367 8687505 SGTC_1364 1653-0028 37.6 µM 0.0101405747273514 0.47322613338026 no 1572 0.495954565326663 2372 5718652 SGTC_438 sphingosine 6.67 µM 0.00878309376446396 0.473773983904382 no 1573 0.496496097594786 2392 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes. SGTC_1207 2099-0101 141 µM 0.00876450478785688 0.473781486367714 no 1574 0.496503513238072 2390 5837381 SGTC_755 1995-0008 37.3 µM 0.00873875699510096 0.473791878126262 no 1575 0.49651378472787 2388 689533 SGTC_832 4083-0019 164 µM 0.00870669877084579 0.473804816787485 no 1576 0.496526573622422 2379 1990758 SGTC_550 4123-0385 25.7 µM 0.00789473397703738 0.474132533990085 no 1577 0.49685048954057 2384 5731123 SGTC_589 1227-0070 34.1 µM 0.00660925887834321 0.47465140044774 no 1578 0.497363306387466 2388 2841384 SGTC_229 benomyl 22.8748 µM 0.00554643545896974 0.475080428761387 no 1579 0.497787303734748 2393 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C SGTC_2155 5570423 76 µM 0.00487457217888288 0.475351653728882 no 1580 0.498055334760324 2389 797402 SGTC_1233 0325-0408 14.2 µM 0.00432684477365014 0.475572774653686 no 1581 0.498273844065121 2394 12874 SGTC_2193 5925765 200 µM 0.00402131739730599 0.475696121209191 no 1582 0.498395730791073 2385 877370 SGTC_819 1013-0258 27.7 µM 0.00309510365440292 0.476070063504814 no 1583 0.498765234261475 2399 5753198 SGTC_2339 9000433 200 µM 0.000447115955419349 0.477139256496536 no 1584 0.499821626547084 2402 2988954 SGTC_1077 5-fluorocytosine 377 nM 0.000248176160607264 0.477219590287126 no 1585 0.499900992037562 2404 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_1629 st005085 44.9 µM 0.000198177677835969 0.477239780298044 no 1586 0.499920938545797 2405 24207091 SGTC_1758 st042942 75.2445 µM 0 0.477319807490204 no 1587 0.5 2406 669317 SGTC_3032 9089427 49.47 µM -0.000145710290000496 0.477378648128412 no 1588 0.499941870004835 2397 17173707 SGTC_2016 5121758 140 µM -0.000542821187695103 0.477539011702597 no 1589 0.499783445688166 2407 2795203 SGTC_2485 5633444 17.78 µM -0.00107655312167418 0.477754552082775 no 1590 0.499570517525625 2409 5724239 SGTC_1177 0983-0204 23.6 µM -0.00137728836259575 0.477876002788608 no 1591 0.499450541613569 2411 766818 SGTC_2965 9082772 38.63 µM -0.00182282926895827 0.478055936447947 no 1592 0.499272796737373 2408 16459634 SGTC_813 k007-0158 173 µM -0.00659434697243647 0.479983207949584 no 1593 0.497369255247575 2425 6523916 SGTC_3028 9087778 49.47 µM -0.00744642780321012 0.480327423859599 no 1594 0.497029332564933 2420 17217395 SGTC_1105 epirubicin 18.1 µM -0.00904525649918276 0.480973343606529 no 1595 0.496391513951183 2417 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_2100 5377183 190 µM -0.010004423817945 0.481360867059186 no 1596 0.496008878925629 2439 2844202 SGTC_1055 3448-0672 86 µM -0.0102968300979718 0.481479008769626 no 1597 0.495892231707428 2454 748378 SGTC_1845 st056753 3.01 µM -0.0108927473293778 0.481719783865608 no 1598 0.495654508474254 2409 5375839 SGTC_822 1487-0950 154 µM -0.0111794609168486 0.481835630340541 no 1599 0.495540133267649 2419 1958375 SGTC_2800 7887935 81.82 µM -0.0114248569197039 0.481934783685598 no 1600 0.495442240679454 2437 2961002 SGTC_317 4495-0002 170 µM -0.0132413985107471 0.482668799731415 no 1601 0.494717600647463 2445 15991618 SGTC_402 epigallocatechin gallate 10 µM -0.0133569846462687 0.482715507022665 no 1602 0.494671492528718 2434 65064 An antioxidant. SGTC_3228 9131799 49.47 µM -0.013954002682519 0.482956760267328 no 1603 0.49443333900101 2438 17015818 SGTC_2651 TUB2.036 5 µM -0.013968046767432 0.482962435516493 no 1604 0.494427736767741 2440 15992207 YFL037W TUB2 SGTC_454 lyso-paf C-16 6.67 µM -0.0142837266660965 0.483090003446664 no 1605 0.49430181127387 2445 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_1130 3454-2858 15.9 µM -0.0147260198223373 0.483268739378232 no 1606 0.494125380395692 2469 715628 YIL048W NEO1 SGTC_296 1222-0039 74.9 µM -0.0149142999065692 0.48334482662485 no 1607 0.494050275757982 2450 5984176 SGTC_3187 9109394 49.47 µM -0.015003994325704 0.4833810739083 no 1608 0.49401449686534 2450 17098090 SGTC_1889 st059080 5.18 µM -0.015121760236876 0.483428665643736 no 1609 0.493967520393765 2432 176925 Isolated from Daphnopsis sellowiana. SGTC_496 calpeptin 138 µM -0.0164771250441909 0.483976414513077 no 1610 0.49342687559087 2473 73364 A calpain inhibitor. SGTC_1149 3909-7961 23.3 µM -0.017804297227153 0.484512799097883 no 1611 0.492897488306318 2441 735261 SGTC_1519 esterone 74 µM -0.0180544291919676 0.484613894597431 no 1612 0.492797716127908 2438 698 A steroid. SGTC_2681 menadione 3.18 µM -0.0194017021479984 0.485158436941625 no 1613 0.492260326273584 2460 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_1279 0874-0590 65.2 µM -0.0194080767993482 0.485161013522184 no 1614 0.492257783634398 2466 3523074 SGTC_59 0330-0160 1.33 µM -0.0197693815259274 0.485307050868843 no 1615 0.492113671555515 2461 4293482 SGTC_411 enrofloxacin 100 µM -0.0202522740392374 0.485502236391441 no 1616 0.491921063884054 2450 71188 A bacterial gyrase inhibitor. SGTC_2069 5228469 200 µM -0.0205282011231917 0.485613767891898 no 1617 0.491811007785244 2465 2835210 SGTC_2859 9028643 45.46 µM -0.0217980102871845 0.486127047287285 no 1618 0.491304540685898 2474 17151580 SGTC_639 0833-0042 114 µM -0.0222408117994656 0.486306040963823 no 1619 0.49112793126239 2464 5978911 YPR085C | YHR062C ASA1 | RPP1 SGTC_137 0438-0332 85.389 µM -0.0229083668593077 0.486575891980895 no 1620 0.49086168317973 2443 2063393 YER012W | YPR107C PRE1 | YTH1 SGTC_2703 st077852 53.4 µM -0.0229706232928808 0.486601058702539 no 1621 0.49083685299009 2461 6281836 SGTC_3013 9080133 71.4286 µM -0.02328707846569 0.486728984284206 no 1622 0.49071063940543 2467 17050193 SGTC_717 1532-0246 73.2 µM -0.0234199497344547 0.48678269730539 no 1623 0.490657645891456 2459 9561992 SGTC_1978 st071761 42 µM -0.0234237087443243 0.486784216883269 no 1624 0.490656146674765 2476 5147680 SGTC_2103 5378138 10 µM -0.023658924828694 0.486879303249702 no 1625 0.490562335032403 2447 244142 SGTC_2364 9055074 200 µM -0.0240334278922658 0.487030698071059 no 1626 0.490412972399908 2460 6470630 SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM -0.0246257291773903 0.487270142769171 no 1627 0.490176748302209 2475 6708760 SGTC_1718 roemerine 11.9335 µM -0.0246314769989054 0.487272466415635 no 1628 0.490174455948527 2453 235224 An aporphine alkaloid with mutagenic activity. SGTC_2136 5328288 199.296 µM -0.0255930838971045 0.487661217018229 no 1629 0.489790951257682 2460 262395 SGTC_464 bw-b 70c 158 µM -0.0256198083330552 0.487672021124624 no 1630 0.489780293245011 2525 5353454 SGTC_1388 3346-4487 254 µM -0.0261755851556845 0.487896711607094 no 1631 0.489558644716117 2472 3345614 SGTC_1919 st067113 52.3 µM -0.0262758467933927 0.487937245978656 no 1632 0.489518659862669 2479 1268243 SGTC_2730 imipramine 71.33 µM -0.0266713081171795 0.488097126647089 no 1633 0.489360948896947 2459 3696 A tricyclic antidepressant. SGTC_294 k038-0071 157 µM -0.0279400525089649 0.48861007885098 no 1634 0.488854981809704 2478 24152826 SGTC_2659 sanguinarine 24.21 µM -0.0284656098669727 0.48882256678021 no 1635 0.488645398129203 2463 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis. SGTC_2724 maprotiline 69.64 µM -0.0311136514649786 0.489893242671612 no 1636 0.487589451323104 2447 4011 A tricyclic antidepressant. SGTC_1590 st077108 57.8 µM -0.033608830418114 0.490902178783322 no 1637 0.486594540296151 2448 5489485 SGTC_1101 ebselen 5.29 µM -0.0337898894049226 0.490975393089673 no 1638 0.486522349214592 2458 3194 A potent scavenger of hydrogen peroxide and hydroperoxides. SGTC_200 k038-0079 37.545 µM -0.0338581847435146 0.491003009560158 no 1639 0.486495118897568 2495 3436683 SGTC_186 3455-3465 67.277 µM -0.0350467617873859 0.491483639238635 no 1640 0.486021226621254 2468 755278 SGTC_1355 1499-0035 1.68 µM -0.0351635989473948 0.491530885829635 no 1641 0.485974644050644 2473 1548538 SGTC_2895 9054447 58.44 µM -0.0352905622206023 0.491582227351268 no 1642 0.485924024450809 2465 2697450 SGTC_1835 st008666 49.2 µM -0.0356374814170173 0.491722515553903 no 1643 0.485785710721893 2479 690455 SGTC_2294 7971431 200 µM -0.0359583236238336 0.49185225957868 no 1644 0.485657795188296 2504 5741572 SGTC_378 3970-0959 8.33 µM -0.0364122231217925 0.492035811548524 no 1645 0.485476834000787 2519 6615653 SGTC_2219 9098279 200 µM -0.0368953923861013 0.492231201742387 no 1646 0.485284206795489 2473 902349 SGTC_576 1073-0113 22.7 µM -0.0372684387633723 0.492382060306171 no 1647 0.485135485110315 2476 5439563 SGTC_2842 9000675 19.48 µM -0.0374626282882125 0.492460590258421 no 1648 0.485058068761134 2512 2989072 SGTC_1473 k844-0725 134 µM -0.0374841954537662 0.49246931200587 no 1649 0.485049470745956 2467 54682906 SGTC_1274 0865-0114 173 µM -0.0378432288113042 0.492614505383221 no 1650 0.484906338716682 2502 870624 SGTC_748 act1.228 77.9 µM -0.039267140779982 0.493190345972132 no 1651 0.48433870213009 2476 4421505 YNR035C ARC35 SGTC_2481 5478948 45.16 µM -0.0393898458305508 0.4932399694883 no 1652 0.484289787740748 2531 77792 SGTC_1482 3346-2049 8.48 µM -0.0398946809645672 0.493444132465599 no 1653 0.484088545852157 2546 3826804 SGTC_1127 asiatic acid 681.4 nM -0.0401764203641196 0.493558072897657 no 1654 0.483976238136016 2489 470603 A kinase inhibitor which arrests cells at G2/M. SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM -0.0410640212365341 0.493917037894615 no 1655 0.483622428645176 2467 66535 A nucleotide analog. SGTC_3275 9138069 49.47 µM -0.0415297732683573 0.494105400082209 no 1656 0.483436778843407 2568 17617007 SGTC_1645 Cervolide 78 µM -0.0416198534538326 0.494141830995843 no 1657 0.483400873093137 2523 23173 A fragrance. SGTC_422 cantharidin 155 µM -0.0431366431040131 0.494755269697607 no 1658 0.482796304749879 2473 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_1678 st019265 80.2 µM -0.0434419435747416 0.494878744610226 no 1659 0.482674621552682 2479 5367020 SGTC_372 0155-0182 15.9 µM -0.0434754350819375 0.494892289856643 no 1660 0.482661272985818 2485 771486 SGTC_929 2805-0021 398 µM -0.0436776916160038 0.494974090259073 no 1661 0.482580660877222 2570 3098024 SGTC_2621 lithochol-11-enic acid 100 µM -0.0444912258679164 0.495303117225464 no 1662 0.482256422898089 2475 6708711 SGTC_828 2074-0507 139 µM -0.0453877480859098 0.49566571165648 no 1663 0.48189912326776 2549 X828 SGTC_1202 1988-0068 29.6 µM -0.0455737044357199 0.49574092133492 no 1664 0.48182501410454 2501 2850480 SGTC_432 NS 1619 61.3 µM -0.0457233060118601 0.495801427506954 no 1665 0.481765393860945 2619 4552 A K+/calcium channel activator. SGTC_2539 epi(13)torulosol 80 µM -0.0458844347741106 0.495866595943118 no 1666 0.481701180180482 2539 6708597 SGTC_2652 actinonin 100 µM -0.0461458736564487 0.495972334984163 no 1667 0.481596991519527 2489 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase. SGTC_3330 9141424 71.43 µM -0.0474439897841737 0.4964973625197 no 1668 0.481079684847953 2502 27261020 SGTC_1329 1447-1697 50.6 µM -0.0475399726392758 0.49653618336781 no 1669 0.481041436387682 2591 2840515 SGTC_505 gw-5074 63.9 µM -0.0498255236253187 0.497460597195492 no 1670 0.480130713514157 2588 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases. SGTC_3313 9133968 57.047 µM -0.0509936846459819 0.497933077116329 no 1671 0.479665276462578 2497 1494643 SGTC_3272 9137413 49.47 µM -0.0513004538364311 0.498057154938889 no 1672 0.479543053236629 2495 17614870 SGTC_2056 5235370 200 µM -0.0535754333466537 0.498977312719366 no 1673 0.478636714871626 2525 5511916 SGTC_2011 4012611 177 µM -0.0541988067428553 0.499229448841442 no 1674 0.478388385685131 2509 2049887 SGTC_283 0987-0079 11.7 µM -0.0545630961687874 0.499376793300763 no 1675 0.478243269964823 2490 411556 SGTC_271 rotenone 740 µM -0.0548210033977455 0.499481109313405 no 1676 0.478140533635512 2617 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria. SGTC_1827 berberine 7.24 µM -0.0550468421131263 0.499572454569451 no 1677 0.478050572864966 2508 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_1018 4259-0013 28.1 µM -0.0556760172196445 0.499826937882494 no 1678 0.47779995267315 2626 6801262 SGTC_68 0986-0284 82.829 µM -0.056531761713329 0.499826937882494 no 1679 0.477459096892877 2728 423278 YIL048W NEO1 SGTC_566 0958-0068 16.5 µM -0.0569479393069043 0.49965860594957 no 1680 0.47729333310157 2525 6815365 SGTC_773 4358-1457 44.6 µM -0.0571236731724409 0.499587526643888 no 1681 0.477223339372949 2499 1186886 SGTC_1545 lovastatin 49.4 µM -0.0577799566435483 0.499322078946732 no 1682 0.476961951891514 2542 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12 SGTC_1119 parthenolide 318.541 nM -0.058254829584345 0.499130006746639 no 1683 0.476772823572046 2656 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs. SGTC_888 0916-0002 6.97 µM -0.0592032656801954 0.498746392764331 no 1684 0.476395104285282 2672 2802138 YIL048W NEO1 SGTC_2573 2',4'-dihydroxychalcone 15.04 µM -0.0597946839153547 0.498507182373399 no 1685 0.476159579811876 2578 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_1212 0520-0165 585 µM -0.0600250740151 0.498413996841674 no 1686 0.476067832258 2645 5403258 SGTC_833 3852-0053 558 µM -0.0620426894208453 0.497597939279206 no 1687 0.475264418110493 2586 3123681 SGTC_1171 0368-0077 21.4 µM -0.0631059120377269 0.497167905322936 no 1688 0.474841083279754 2528 3239779 SGTC_615 k087-0205 167 µM -0.0653720395223418 0.49625135275194 no 1689 0.473938892838068 2539 9642773 SGTC_1944 st076371 56.9 µM -0.0655645552013338 0.496173489158939 no 1690 0.473862254609786 2528 24208455 SGTC_2956 9076196 2.52 µM -0.0660558864144698 0.495974769318241 no 1691 0.473666665822141 2523 16423868 SGTC_2572 astragaloside iv 100 µM -0.0661738154990615 0.495927072823167 no 1692 0.473619721637027 2677 45006101 An anti-inflammatory agent. SGTC_726 3448-4391 34.2 µM -0.0669810403071202 0.495600591822679 no 1693 0.473298398470871 2611 1356692 SGTC_2788 5282734 71.43 µM -0.0674341048726644 0.495417351738461 no 1694 0.473118059604227 2586 743706 SGTC_3212 9128307 49.47 µM -0.0679192291919201 0.49522114629278 no 1695 0.472924965708326 2569 27243542 SGTC_1666 st014829 29 µM -0.0681213100980599 0.495139416293808 no 1696 0.472844533376764 2518 3858230 SGTC_1280 0880-0253 10.1 µM -0.0683530947919731 0.495045673087926 no 1697 0.472752279693974 2558 6836607 SGTC_679 0422-0091 41.4 µM -0.068511816969365 0.494981479508121 no 1698 0.472689106799318 2518 627384 YHR062C RPP1 SGTC_2326 6164455 177.58 µM -0.0686087649435961 0.494942269944008 no 1699 0.472650520946726 2573 2888790 SGTC_2878 9043973 25.97 µM -0.0713366774062456 0.493839016560967 no 1700 0.471564902612033 2690 6465167 SGTC_278 4092-0821 23.9 µM -0.0728139045084911 0.493241598705788 no 1701 0.470977103065565 2603 877900 SGTC_1139 k015-0024 46.9 µM -0.0729147469216411 0.493200816713625 no 1702 0.470936979417255 2516 2766652 SGTC_3182 9108849 49.47 µM -0.0735131351336995 0.492958822162638 no 1703 0.470698896015759 2594 17133045 SGTC_2612 dictamnine 15.46 µM -0.0735432405267079 0.492946647289548 no 1704 0.470686918124026 2614 68085 A quinoline derivative and established mutagen. YOR116C RPO31 SGTC_2524 avocatin b 10.57 µM -0.0747936568107567 0.492440974410231 no 1705 0.470189444407195 2582 6710748 SGTC_538 2922-0838 53.3 µM -0.0754274913335647 0.492184654019222 no 1706 0.469937293293246 2532 777039 SGTC_1995 st072814 61.1 µM -0.0759285597491179 0.491982026040964 no 1707 0.469737967522658 2551 5769371 SGTC_513 4245-1575 41.7 µM -0.0763227645718527 0.491822614279115 no 1708 0.4695811575776 2686 719745 SGTC_61 0978-8327 98.565 µM -0.0763320938942822 0.491818841627329 no 1709 0.469577446542212 2546 6150059 YHR072W ERG7 SGTC_2968 9090663 33.37 µM -0.0768501023991838 0.491609367153479 no 1710 0.469371396303072 2651 25236811 SGTC_1246 0422-0085 105 µM -0.0769851085617125 0.49155477316729 no 1711 0.4693176957268 2557 264295 SGTC_2792 7535235 81.82 µM -0.0787894577465996 0.490825143439349 no 1712 0.468600044739408 2615 1281891 SGTC_2752 diclazuril 33.15 µM -0.0798310509841591 0.49040396528691 no 1713 0.46818581400721 2592 456389 An antifungal agent for coccidioides. YHR062C RPP1 SGTC_330 1488-0319 80.1 µM -0.0799449040441314 0.490357928357269 no 1714 0.468140537916641 2612 6846614 SGTC_2743 auranofin 4.32 µM -0.0804160998525967 0.490167399863756 no 1715 0.467953161271184 2581 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold. SGTC_2412 st077135 33.4 µM -0.0806435885570443 0.49007541538037 no 1716 0.467862700207451 2833 13258915 SGTC_2191 5911152 200 µM -0.0809121834877311 0.489966810378067 no 1717 0.467755895357055 2556 2875902 SGTC_2453 5731132 22.18 µM -0.0809838435870572 0.489937835104565 no 1718 0.467727400623744 2611 1362040 SGTC_2977 9011197 71.43 µM -0.0812105920027747 0.489846151276313 no 1719 0.467637238070591 2756 2704722 SGTC_1135 dihydrocapsaicin 536.708 nM -0.0812833515374929 0.489816731679554 no 1720 0.467608306862123 2533 107982 A Capsaicinoid. SGTC_2598 perillyl alcohol 100 µM -0.0815627696933088 0.489703752233826 no 1721 0.467497204047294 2637 10819 An apoptosis inducer. SGTC_1647 st011722 22.4 µM -0.0816990484956372 0.489648649801715 no 1722 0.467443017511104 2616 2854783 SGTC_1014 4130-3005 69.3 µM -0.0834948419649745 0.488922564623743 no 1723 0.466729039294362 2566 743608 SGTC_1597 7-benzyloxygramine 47.5 µM -0.0839378163937566 0.488743464297068 no 1724 0.466552936251886 2543 260807 SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM -0.0843249103832363 0.488586959016446 no 1725 0.466399053655912 2654 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_927 2425-1185 123 µM -0.0846616648481222 0.48845080784785 no 1726 0.466265186761869 2543 730375 SGTC_2371 9071574 200 µM -0.0853288072290899 0.488181083521283 no 1727 0.465999995093566 2542 45596039 SGTC_1318 1280-3875 124 µM -0.0858118184179122 0.487985806432885 no 1728 0.46580800569848 2605 373245 SGTC_481 bay k-8644 50 µM -0.0860277020965484 0.487898527527842 no 1729 0.465722197882296 2553 2303 A calcium channel antagonist. SGTC_3199 9111318 49.47 µM -0.0865966749227551 0.487668502155814 no 1730 0.465496054500158 2628 8548020 SGTC_997 3996-0078 137 µM -0.0872310278394667 0.487412049641335 no 1731 0.465243938350692 2602 735687 SGTC_2177 5811945 192 µM -0.0875112029695825 0.487298783717144 no 1732 0.465132590456714 2662 5343475 SGTC_360 0957-0399 1.01 µM -0.0879164892402509 0.487134941139852 no 1733 0.464971525416615 2656 6752301 YPR165W RHO1 SGTC_3143 9086658 49.47 µM -0.0882774823901499 0.486989006496465 no 1734 0.464828067761585 2648 25236626 SGTC_2110 5483698 200 µM -0.0886831044052744 0.48682503232294 no 1735 0.464666880177136 2618 2848765 YHR062C RPP1 SGTC_2295 7971645 200 µM -0.0898966501266275 0.486334465465656 no 1736 0.464184671593514 2641 2978226 YKL099C UTP11 SGTC_2197 6588183 93.1375 µM -0.0907628961444902 0.485984304543016 no 1737 0.463840496453646 2570 884136 SGTC_1154 4088-0362 150 µM -0.0913439920897072 0.485749415312276 no 1738 0.463609631720252 2562 6618304 SGTC_1190 1486-1332 13 µM -0.0919876604070793 0.485489238999931 no 1739 0.463353921795365 2557 4150046 SGTC_2770 toltrazuril 17.5 µM -0.0923884440966583 0.4853272418726 no 1740 0.463194710217516 2562 68591 Kills coccidiodes. SGTC_1392 3455-1037 33.9 µM -0.0929643452006114 0.485094466375676 no 1741 0.462965943462496 2684 981132 SGTC_1142 3253-1408 9.78 µM -0.0940904472228205 0.484639317979428 no 1742 0.462518654364172 2549 256655 SGTC_2534 helenine 20.12 µM -0.0945118986793664 0.484468980664492 no 1743 0.462351265487822 2579 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58 SGTC_1601 4'-hydroxyflavanone 55.5 µM -0.0946178375461337 0.484426163978293 no 1744 0.462309190543856 2731 165506 SGTC_2839 9003951 25.97 µM -0.0973713222165205 0.4833133687683 no 1745 0.461215759021743 2552 2990634 SGTC_1584 6-fluoro-dl-tryptophan 90 µM -0.0979801008162401 0.483067353802261 no 1746 0.460974047287931 2764 94937 An inhibitor of serotonin biosynthesis. SGTC_2241 6772625 37.8075 µM -0.0986367203930274 0.482802012934626 no 1747 0.460713356757352 2554 2285411 SGTC_960 1222-0186 7.7 µM -0.100260271997828 0.482145966462894 no 1748 0.460068848436059 2686 3126296 SGTC_1315 1237-0019 3.69 µM -0.100271851511043 0.482141287572307 no 1749 0.460064252041247 2617 825140 SGTC_49 0717-0965 32.132 µM -0.100349146353374 0.482110055397557 no 1750 0.460033570610833 2868 5889349 YGL099W LSG1 SGTC_2420 aureobasidin a 50 nM -0.100455261895081 0.482067177953003 no 1751 0.459991449473816 2864 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1 SGTC_654 1124-0271 80.9 µM -0.101909818312261 0.48147946554099 no 1752 0.459414128327235 2625 5403748 SGTC_954 1189-0853 2.85 µM -0.102565537213804 0.481214535904172 no 1753 0.459153897932805 2554 2828194 SGTC_191 3914-0123 66.505 µM -0.102738329142968 0.481144724281538 no 1754 0.459085326164799 2591 3144412 SGTC_700 3453-2283 142 µM -0.103149443645648 0.480978627587607 no 1755 0.458922181958815 2705 565664 SGTC_3084 9116877 49.47 µM -0.103436742471037 0.480862556323702 no 1756 0.458808176126313 2573 27241325 SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM -0.103587478921289 0.480801658114274 no 1757 0.458748362288446 2626 279621 SGTC_1967 st070177 51.4 µM -0.103837475427503 0.480700659380562 no 1758 0.458649163056887 2697 5729214 SGTC_551 k048-0028 34.9 µM -0.104562170069046 0.480407889348476 no 1759 0.458361617005636 2679 6836383 SGTC_1573 oleylamine 1.06 µM -0.104635046316636 0.480378448590657 no 1760 0.458332702199231 2579 5356789 An amine of the fatty acid oleic acid. SGTC_2027 5150920 200 µM -0.104801350726679 0.480311264853925 no 1761 0.458266719114346 2665 786715 SGTC_3339 9145883 14.936 µM -0.105921728230056 0.47985866887387 no 1762 0.457822227205416 2652 2030670 SGTC_1820 st053765 18.6 µM -0.107095923728904 0.479384360055228 no 1763 0.457356440481556 2667 3690829 SGTC_1861 st057647 17.4 µM -0.107288559055953 0.479306549007084 no 1764 0.457280030351377 2792 688668 SGTC_2912 7964298 10.93 µM -0.109971818837133 0.478222785151451 no 1765 0.456215862319644 2669 2975850 SGTC_1276 0871-0068 94.2 µM -0.109999177673844 0.478211735781556 no 1766 0.456205013539595 2690 3414906 SGTC_2413 inermin 26.06 µM -0.110185876325929 0.478136334541221 no 1767 0.456130981563153 2854 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1 SGTC_2988 9073640 71.4286 µM -0.11029916419168 0.478090581803838 no 1768 0.456086060049608 2734 9102229 SGTC_2101 5377231 179.231 µM -0.111452854456159 0.477624665947098 no 1769 0.455628624647726 2689 2844213 SGTC_1476 4112-3294 3.34 µM -0.11262699449444 0.47715052288635 no 1770 0.455163141350811 2720 704369 SGTC_2753 fluvastatin 17.09 µM -0.114085808296444 0.476561467555662 no 1771 0.454584886053221 2678 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5 SGTC_2276 7947513 42.08 µM -0.115371808475181 0.476042235175804 no 1772 0.454075211652008 2699 2105100 SGTC_2914 7968218 45.32 µM -0.118695631577082 0.474700406840013 no 1773 0.452758248789122 2703 2977111 SGTC_2403 6032726 181.2 µM -0.119097841203963 0.474538053857677 no 1774 0.4525989205206 2673 2881040 SGTC_1221 2958-7315 257 µM -0.119462341766338 0.474390925890702 no 1775 0.452454536626211 2702 4562705 SGTC_1843 st055809 45.5 µM -0.119726530015133 0.474284290432111 no 1776 0.452349891804882 2744 16413835 SGTC_1020 4335-0961 93.3 µM -0.120713482711934 0.473885938756617 no 1777 0.45195898971705 2598 669075 SGTC_3280 9140961 49.47 µM -0.120772832604027 0.47386198491207 no 1778 0.451935484501978 2605 4901226 SGTC_1874 staurosporine 7.6 µM -0.120913068433259 0.473805385568043 no 1779 0.451879945503092 2720 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1 SGTC_2254 7938975 95.19 µM -0.120914468997155 0.473804820301488 no 1780 0.451879390828505 2801 2969277 SGTC_799 1310-0557 151 µM -0.121285888011158 0.473654917726635 no 1781 0.451732298617243 2750 5354492 SGTC_1936 st074407 74.3 µM -0.121361253764645 0.473624500997179 no 1782 0.451702452500585 2614 809813 SGTC_230 MPP+ 141.667 µM -0.121640775441611 0.473511690688401 no 1783 0.451591759560649 2659 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death. SGTC_1324 1418-0026 34.4 µM -0.122063484795629 0.473341096248175 no 1784 0.451424370245929 2717 1372513 SGTC_1912 st060209 90.8 µM -0.122063783627502 0.473340975649172 no 1785 0.451424251914096 2691 688787 SGTC_2444 5485484 36.41 µM -0.12253896186616 0.473149211981881 no 1786 0.451236095686128 2720 6790631 SGTC_2991 9074669 71.4286 µM -0.12331079509485 0.472837743048494 no 1787 0.450930496412277 2746 17333109 SGTC_2312 7706453 155.7 µM -0.123318751936746 0.472834532196115 no 1788 0.450927346135311 2659 976098 SGTC_1903 st060211 78.3 µM -0.123372792771289 0.47281272495491 no 1789 0.450905950341905 2741 688960 SGTC_2398 5228213 48.84 µM -0.123741901408102 0.472663779750761 no 1790 0.450759817035657 2668 80771 YMR134W ERG29 SGTC_2726 cimetidine 79.27 µM -0.124647277523651 0.472298452509119 no 1791 0.450401399094172 2626 2756 A P450 inhibitor, histamine H2-receptor antagonist. SGTC_2143 5623677 140.463 µM -0.12525953652325 0.472051413796123 no 1792 0.450159042500439 2606 5375313 SGTC_1360 1598-0022 39.8 µM -0.125575746587959 0.471923831264355 no 1793 0.450033881185506 2721 761525 SGTC_2766 oltipraz 83.91 µM -0.125602919532577 0.47191286782261 no 1794 0.450023125904164 2702 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40 SGTC_2411 st077133 39.94 µM -0.125648547176522 0.471894458529009 no 1795 0.450005066179288 2932 1403142 YNL221C POP1 SGTC_789 1309-1135 70.6 µM -0.125752125392453 0.471852668257783 no 1796 0.449964069617028 2637 3092424 SGTC_2166 5933061 31.504 µM -0.125785876395586 0.47183905094809 no 1797 0.449950710986129 3111 2877375 SGTC_724 3910-0327 137 µM -0.1267511885732 0.471449596376583 no 1798 0.449568664953128 2676 2885483 SGTC_1607 st000305 50.6 µM -0.127465433203419 0.471161452396033 no 1799 0.449286015144079 2780 5457690 SGTC_264 promethazine 12.5 mM -0.12788938900548 0.470990425251276 no 1800 0.44911825421778 2622 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3 SGTC_495 decylubiquinone 155 µM -0.128208098241435 0.470861858930015 no 1801 0.448992145746049 2690 2971 A Co-enzyme Q analog. A free radical scavenger. SGTC_762 1165-0429 115 µM -0.128562697962321 0.470718818067755 no 1802 0.448851842003381 2723 5967793 SGTC_869 0564-0080 44.1 µM -0.129573459159062 0.470311111092303 no 1803 0.448451951356634 2683 6843321 SGTC_3148 9097893 49.47 µM -0.129697525977293 0.470261068858201 no 1804 0.448402870009711 2666 17174100 SGTC_1214 0358-0031 63.7 µM -0.129823045466186 0.470210441168703 no 1805 0.448353214783958 2931 4301366 SGTC_3160 9100216 49.47 µM -0.129891829136585 0.470182697806232 no 1806 0.44832600446275 2600 17191039 SGTC_972 1319-0219 195 µM -0.130459261022857 0.469953834069703 no 1807 0.448101541810131 2691 23903702 SGTC_1829 berberine 14.4 µM -0.13153923260043 0.469518273889314 no 1808 0.447674376526084 2810 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_695 3505-6186 243 µM -0.132434336505582 0.469157299769479 no 1809 0.447320378624629 2749 1819379 SGTC_1422 4031-0024 15.5 µM -0.132442735036158 0.469153912961393 no 1810 0.447317057351297 2621 782427 SGTC_129 0088-0017 176.636 µM -0.132649539142585 0.469070517432311 no 1811 0.447235276001072 2656 182446 SGTC_1704 st028805 70.8 µM -0.133567906644996 0.468700194306366 no 1812 0.446872131762727 2680 2876101 SGTC_1914 st062367 72.6 µM -0.133824642538876 0.468596672782339 no 1813 0.446770620269747 2674 978205 SGTC_2028 5153890 36.43 µM -0.134282012333848 0.46841225654909 no 1814 0.44658978824614 2651 2830968 YPR165W RHO1 SGTC_1946 st076057 65.1 µM -0.134773031606512 0.46821428004369 no 1815 0.446395664463831 2641 953009 SGTC_2555 cholic acid 100 µM -0.134878913799743 0.468171589903624 no 1816 0.446353805769034 2805 6708657 Influences liver metabolism. SGTC_3229 9132204 49.47 µM -0.135195456896513 0.468043966576143 no 1817 0.446228669494339 2633 17682924 SGTC_3007 9078383 71.4286 µM -0.137178832006033 0.467244387927812 no 1818 0.445444721166316 2692 6496995 SGTC_324 1315-0088 19.6 µM -0.137750756731833 0.467013846367599 no 1819 0.445218701830336 2716 6787421 SGTC_1848 st056003 16.4 µM -0.14048615859009 0.465911366448134 no 1820 0.444137943940112 2636 146492 SGTC_247 mechlorethamine 29.705 µM -0.140878587905577 0.465753222482357 no 1821 0.443982928902586 2648 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links. SGTC_190 3970-0790 3.722 µM -0.141132181008219 0.465651030599231 no 1822 0.443882760656875 2617 2832352 SGTC_1138 3761-0006 1.03 µM -0.143220767151513 0.464809467690772 no 1823 0.443057914540445 2644 12061087 SGTC_3018 9082602 49.47 µM -0.143238300874016 0.464802403414224 no 1824 0.44305099098006 2659 17332089 SGTC_780 0109-0199 192 µM -0.143553020501875 0.46467560584639 no 1825 0.442926720251913 2853 610414 SGTC_2138 5575593 77.673 µM -0.144262566099218 0.464389749801319 no 1826 0.442646568484958 2653 762213 SGTC_2476 5806916 10.51 µM -0.144656232959021 0.464231160369099 no 1827 0.442491148315585 2681 2870194 SGTC_2357 9067248 200 µM -0.145644253006958 0.463833159725463 no 1828 0.442101115795907 2742 9150235 SGTC_2230 bromochlorosalicylanilide 954.5 nM -0.14577928179836 0.463778769354157 no 1829 0.442047815945113 2670 77254 SGTC_957 1187-1561 14.1 µM -0.147275770432938 0.463176020707152 no 1830 0.441457178156834 2653 1538454 SGTC_764 1951-2361 146 µM -0.147280785250538 0.463174001003862 no 1831 0.441455199114474 2690 5438930 SGTC_1085 doxorubicin 7.67 µM -0.147528937768752 0.46307405948131 no 1832 0.441357270291596 2728 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_3321 9137793 26.8275 µM -0.14768302200174 0.463012004411293 no 1833 0.441296465589474 2671 4904192 SGTC_3209 9113616 49.47 µM -0.148446557941612 0.462704515290585 no 1834 0.440995179568879 2743 16649353 SGTC_3174 9107204 49.47 µM -0.149292530999061 0.462363853348691 no 1835 0.440661404313262 2775 3938802 SGTC_1152 3909-8331 15.9 µM -0.149514500030069 0.462274473974851 no 1836 0.440573834299407 2671 16001939 SGTC_2022 5136654 200 µM -0.150172235235089 0.462009637597091 no 1837 0.440314365267456 2817 1713771 SGTC_1784 st039334 36.3 µM -0.150268049067792 0.461971059662391 no 1838 0.440276569939842 2911 3496984 SGTC_3015 9080845 49.47 µM -0.150284056855772 0.461964614412881 no 1839 0.440270255460066 2785 5296973 SGTC_779 1360-0071 233 µM -0.151475251265828 0.461485029430858 no 1840 0.439800416093664 2875 7566 SGTC_2619 obliquin 87.91 µM -0.151561863877454 0.46145016063375 no 1841 0.439766257029749 2689 6708593 A bioactive alkalod. YER133W GLC7 SGTC_1769 st044406 64.4 µM -0.152077779399119 0.461242467773019 no 1842 0.43956279490646 2671 670903 SGTC_8 0354-0001 70 µM -0.152648641026502 0.461012667500236 no 1843 0.439337682237888 2682 4993152 SGTC_2182 6325192 200 µM -0.153278388585674 0.460759177808263 no 1844 0.439089371342477 2665 736248 SGTC_1605 st000082 49.1 µM -0.153669120732947 0.460601906015078 no 1845 0.438935316810451 2809 1114022 SGTC_15 0266-0086 27.098 µM -0.153931587474992 0.460496265196864 no 1846 0.438831838858378 2716 1712902 YIL048W NEO1 SGTC_3305 9127027 53.8275 µM -0.15413674084311 0.460413694506007 no 1847 0.438750959710436 2730 41905295 SGTC_486 niguldipine 82 µM -0.154811582322749 0.460142094516168 no 1848 0.438484929963455 2660 1236 A calcium channel blocker. SGTC_2342 7990637 118.86 µM -0.156861316915158 0.45931726289086 no 1849 0.437677073504359 2789 2033102 YER133W GLC7 SGTC_1027 k015-0025 8.67 µM -0.157766475226033 0.458953074571355 no 1850 0.437320408328088 2673 3598955 SGTC_179 1273-0063 6.77 µM -0.158036177020665 0.458844567335254 no 1851 0.437214145882728 2702 3108139 SGTC_1815 st051655 58.2 µM -0.159563269457464 0.458230240986707 no 1852 0.436612557456388 2706 5984156 SGTC_3278 9139605 49.47 µM -0.159703525957532 0.458173822883446 no 1853 0.436557311621838 2901 7958859 SGTC_368 fentichlor 4.58 µM -0.15971004672169 0.458171199929989 no 1854 0.43655474317876 2767 7329 A pesticide. SGTC_2188 6126565 140.678 µM -0.159985364837396 0.458060455891581 no 1855 0.436446301442832 2759 874518 SGTC_2322 7413319 38.22 µM -0.160673241401532 0.457783778471082 no 1856 0.436175382922115 2810 1840400 SGTC_961 1252-1571 372 µM -0.160895121858812 0.457694538164419 no 1857 0.43608800222125 2817 6813498 SGTC_3328 9140624 29.0385 µM -0.160977821296025 0.457661277001094 no 1858 0.43605543442388 2858 4904392 SGTC_2820 7989630 71.43 µM -0.16169574268303 0.457372546281855 no 1859 0.435772728635038 2722 2984098 SGTC_1244 0416-0015 52.5 µM -0.162571588299163 0.457020332715459 no 1860 0.435427879300195 2714 96201 SGTC_1969 st069479 40.1 µM -0.162901877587464 0.456887518551063 no 1861 0.435297846238103 2850 3895485 SGTC_1521 st012942 49.4 µM -0.163482724467656 0.456653963196062 no 1862 0.435069187019598 2934 24207259 SGTC_1896 st058441 89 µM -0.164683739754195 0.456171089093408 no 1863 0.434596458010453 2735 688759 SGTC_2984 9022109 38.96 µM -0.16650968744033 0.455437082082402 no 1864 0.433877930059038 2712 6459207 SGTC_2707 st078556 66.6 µM -0.167689251266652 0.454962993604052 no 1865 0.433413876346861 2780 17250899 SGTC_3281 9140613 49.47 µM -0.16880090170457 0.454516259463571 no 1866 0.432976624523095 2743 16013766 SGTC_2951 9072950 58.06 µM -0.16974294288638 0.454137730466383 no 1867 0.43260615027738 2705 16488155 SGTC_849 0386-0493 241 µM -0.171479884506189 0.453439905703748 no 1868 0.431923223003562 2718 726119 SGTC_599 1935-0052 86.5 µM -0.171724013238092 0.453341837267303 no 1869 0.431827253206705 2704 9557311 SGTC_3319 9138450 16.7555 µM -0.172399319128919 0.453070576405902 no 1870 0.431561803710885 2740 2029690 SGTC_674 0498-0004 451 µM -0.172965836559487 0.452843031221015 no 1871 0.431339140655513 2756 4231473 SGTC_3255 9139072 49.47 µM -0.173161441743388 0.452764468797071 no 1872 0.431262265387424 2775 17646060 SGTC_1932 st074806 40.9 µM -0.173465382807167 0.452642398265079 no 1873 0.431142817939647 2957 17251235 SGTC_410 α-linolenic acid 100 µM -0.174519450154714 0.452219092514566 no 1874 0.430728623151655 2839 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_1961 st076550 68.7 µM -0.177095771833005 0.451184690088593 no 1875 0.429716581511618 2842 1579337 SGTC_816 0325-0417 81.3 µM -0.177364575190576 0.451076783544962 no 1876 0.429611015517268 2781 68101 SGTC_1893 st059353 36.1 µM -0.177750397181144 0.450921908178838 no 1877 0.429459502093144 2769 3112488 SGTC_1880 MG-132 525 µM -0.178318783479782 0.450693762079967 no 1878 0.429236314066081 2812 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1 SGTC_1053 3366-3204 134 µM -0.178937632179053 0.450445379269029 no 1879 0.428993336711453 2770 3632071 YPR165W RHO1 SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM -0.179311841899761 0.450295194838935 no 1880 0.428846424528081 3135 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W SGTC_2282 7944268 200 µM -0.180631248330597 0.449765724363539 no 1881 0.428328513348833 2876 2970414 SGTC_2273 7815444 169.05 µM -0.182347919584973 0.449076967709644 no 1882 0.427654847313925 2928 2824616 SGTC_1895 st058434 18.3 µM -0.182350438291706 0.449075957275415 no 1883 0.427653859062936 2900 5393175 SGTC_1897 st060201 15 µM -0.182927654920554 0.448844402938672 no 1884 0.427427391759526 2762 611878 SGTC_2020 4017018 200 µM -0.186542083098017 0.447394849989715 no 1885 0.426009840216741 2828 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope. SGTC_2391 6285546 200 µM -0.187596098625775 0.446972272403626 no 1886 0.425596642396897 2712 846083 SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM -0.18843877185157 0.446634469789603 no 1887 0.425266354261646 2720 91467 include heat shock SGTC_656 4090-1979 187 µM -0.1889049124587 0.446447624512526 no 1888 0.425083671656905 2835 22330961 SGTC_2780 5215298 71.43 µM -0.189777611990923 0.446097848354021 no 1889 0.424741700055233 2852 2834131 SGTC_1831 st055328 12 µM -0.1910211328479 0.445599520302904 no 1890 0.424254518196422 2887 1103068 SGTC_1703 st026983 48.3 µM -0.192130669551067 0.445154957526897 no 1891 0.423819925797838 2873 1104023 SGTC_94 0334-0113 514.748 µM -0.192214544204863 0.445121353910448 no 1892 0.42378707684791 2759 6795178 SGTC_1078 idebenone 36.1 µM -0.193093134496397 0.444769378453706 no 1893 0.423443014678363 2820 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen. SGTC_543 3844-1095 191 µM -0.193236494263513 0.44471195066744 no 1894 0.423386879511976 2845 4230703 SGTC_1222 0366-0074 1.18 µM -0.193466956940349 0.444619633186442 no 1895 0.423296640851243 2876 286520 SGTC_1148 3909-7663 27.7 µM -0.193662696535553 0.444541227246945 no 1896 0.423220001323306 2890 4084526 SGTC_458 nppb 133 µM -0.195135290973101 0.443951430938061 no 1897 0.422643517693722 2911 4549 A chloride channel blocker. SGTC_2581 avocatin a 64 µM -0.195693375301034 0.443727942098218 no 1898 0.422425084951811 2814 6710728 A skin care supplement. SGTC_1481 3346-2004 36 µM -0.195836684974047 0.443670555604937 no 1899 0.422368997768393 2772 2770522 SGTC_2203 7227154 166.4 µM -0.195982941940431 0.443611990124316 no 1900 0.422311758724172 2755 896304 SGTC_1209 2323-2347 50.3 µM -0.197302466954271 0.443083670326008 no 1901 0.421795424470979 2739 5412760 SGTC_1494 4358-1428 177 µM -0.197765105557675 0.442898460053042 no 1902 0.42161442432189 2882 1564571 SGTC_2943 9068529 45.32 µM -0.202203059615034 0.441122432874993 no 1903 0.419878990654276 2750 3270634 SGTC_2893 9048488 25.97 µM -0.203684586516877 0.440529801547777 no 1904 0.419299993937638 2781 6467338 SGTC_1722 st034304 3.6505 µM -0.204453779012407 0.440222166310655 no 1905 0.418999454019276 2798 4036148 YLR033W RSC58 SGTC_810 3825-7150 143 µM -0.204678216889944 0.440132410136722 no 1906 0.418911770251414 2965 22330411 YGL099W LSG1 SGTC_39 0986-0283 58.349 µM -0.205996517207989 0.439605263732241 no 1907 0.418396815915657 2923 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2 SGTC_1399 3562-5772 25 µM -0.206019283314873 0.439596161227319 no 1908 0.418387924247029 2730 23847490 SGTC_673 1082-0474 110 µM -0.207115604180185 0.439157860394824 no 1909 0.417959787969892 2782 3098046 SGTC_601 0986-0029 62.9 µM -0.208123363693505 0.438755031500886 no 1910 0.417566322487968 2794 24747981 SGTC_2862 9027634 71.43 µM -0.208388023376821 0.438649250325101 no 1911 0.417463003514384 2735 5012562 SGTC_2571 chrysanthemic acid 100 µM -0.211058146534141 0.437582281779881 no 1912 0.416420949380068 2835 2743 An insecticide. SGTC_1533 dihydroergotamine mesylate 29.4 µM -0.211336490733298 0.437471082739194 no 1913 0.416312355203389 2775 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release. SGTC_3034 9090421 49.47 µM -0.213024805064389 0.436796704070523 no 1914 0.415653807531899 2762 17173761 SGTC_1640 st009078 66.4 µM -0.213876027347121 0.436456762161659 no 1915 0.415321867543695 2919 690618 SGTC_1051 3253-3903 78 µM -0.215451478463248 0.435827718096153 no 1916 0.414707669122238 2743 5509239 SGTC_2344 7990960 76.95 µM -0.215682117544625 0.435735642407012 no 1917 0.414617770644107 2828 140813 SGTC_592 k241-0073 46.5 µM -0.215748124596296 0.435709291725597 no 1918 0.414592043244933 2900 4230158 SGTC_1245 0418-0076 17.2 µM -0.216298613011613 0.43548954231977 no 1919 0.414377495067013 2971 6790114 SGTC_493 zm226600 134 µM -0.21739341179057 0.435052568987482 no 1920 0.413950882533973 2978 5240098 A potassium channel opener. YCR052W RSC6 SGTC_2149 5554786 194.827 µM -0.217575769220872 0.434979791308677 no 1921 0.413879832782556 2814 745063 YPR165W RHO1 SGTC_2112 5488546 200 µM -0.21789378736301 0.434852877583163 no 1922 0.413755933911378 2785 600757 SGTC_932 2857-0803 154 µM -0.218918826357508 0.434443853846293 no 1923 0.413356640424763 3020 674898 SGTC_3243 9134147 49.47 µM -0.219234627243166 0.434317853189 no 1924 0.413233641444717 2834 24282180 SGTC_2512 diallyl trisulfide 49.23 µM -0.219925740534273 0.434042130807878 no 1925 0.412964494503052 2776 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent SGTC_1 0258-0098 57.368 µM -0.22065698154425 0.433750434252572 no 1926 0.412679764774874 2854 6790032 YDR047W HEM12 SGTC_403 arphamenine a 50 µM -0.221136554929415 0.433559149046311 no 1927 0.412493054012463 2794 5487158 An arginine aminopeptidase inhibitor. SGTC_917 harmaline 728.087 nM -0.221253015656585 0.433512699244207 no 1928 0.412447715718802 2914 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7 SGTC_3152 9099253 49.47 µM -0.221437968066271 0.433438933750724 no 1929 0.412375715936235 2893 25236131 SGTC_814 3342-0569 96 µM -0.221908977366591 0.433251089235284 no 1930 0.412192370916145 2785 4346283 SGTC_2734 clemastine 41.6 µM -0.222317479801509 0.433088185463266 no 1931 0.412033372825767 2777 26987 Clemastine is a selective histamine H1 antagonist. SGTC_1161 k007-0610 110 µM -0.222714290370903 0.432929955092479 no 1932 0.411878939290299 2879 5843850 SGTC_1855 st056195 39.6 µM -0.222886049782603 0.432861468426725 no 1933 0.411812096982111 2986 4028379 SGTC_2593 nobiletin 86.24 µM -0.223233913878109 0.432722768658856 no 1934 0.411676729190329 2878 72344 An anti-infammatory. SGTC_2217 6934799 96.0675 µM -0.224337732955327 0.432282710792839 no 1935 0.411247258840336 2884 675606 SGTC_1041 0206-0046 107 µM -0.224426796385569 0.432247207665854 no 1936 0.41121261095892 2886 50494 SGTC_113 0099-0221 2.5 µM -0.224595406991309 0.432179996350621 no 1937 0.411147019151805 2971 89219 SGTC_1589 2',5'-dimethoxyflavone 47.2 µM -0.225267025897574 0.431912296094045 no 1938 0.410885774978792 2767 688667 SGTC_2890 9046729 58.44 µM -0.225614757654534 0.431773706135676 no 1939 0.41075053091402 2836 903329 SGTC_1417 3966-0327 90.4 µM -0.227291453981589 0.431105569898232 no 1940 0.410098558979713 2853 651118 SGTC_2159 5658611 73.75 µM -0.22866937245923 0.430556639239887 no 1941 0.409562950659914 2841 793844 SGTC_2493 resveratrol 26.09 µM -0.229276450329567 0.430314836053204 no 1942 0.409327027956089 2778 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase. SGTC_1444 4112-3581 28 µM -0.229775270838944 0.43011617205042 no 1943 0.409133200816845 2810 2877249 SGTC_2007 4011539 71.82 µM -0.229893921143233 0.430068920091514 no 1944 0.409087100028853 2802 45595301 SGTC_1543 azetidyl-2-carboxylic acid 198 µM -0.234466733578225 0.42824858718986 no 1945 0.407311328099138 2794 16486 A toxic proline analog. SGTC_1453 4237-0541 195 µM -0.234822984507681 0.428106835340109 no 1946 0.407173063712505 2951 739892 SGTC_885 0865-0106 16.8 µM -0.234903428358667 0.428074828104258 no 1947 0.407141844286124 2814 2793380 SGTC_893 0958-0369 48.9 µM -0.235377077268779 0.427886380886525 no 1948 0.40695803801291 2969 6819948 SGTC_2125 5246583 200 µM -0.236095762014001 0.427600474483912 no 1949 0.406679181205374 2913 835267 SGTC_2207 7258803 200 µM -0.237139886391933 0.427185169803264 no 1950 0.406274134928751 2908 3666799 SGTC_1181 1222-0449 220 µM -0.237591778000475 0.427005453084734 no 1951 0.40609886407089 3013 658318 SGTC_3344 9148862 3.898 µM -0.237691833314527 0.42696566326074 no 1952 0.406060059120492 2971 4905352 SGTC_1303 1160-0052 261 µM -0.238870888470903 0.426496834728927 no 1953 0.405602849903912 2843 3562476 SGTC_84 0443-0269 128.823 µM -0.239595156653423 0.426208894903838 no 1954 0.405322059929377 2822 6150058 SGTC_986 1493-0483 84 µM -0.240343330923663 0.42591149228441 no 1955 0.405032053017059 2899 40079 SGTC_2050 5263056 171 µM -0.241277325873973 0.425540284266079 no 1956 0.404670091587809 2993 763468 YGL055W OLE1 SGTC_70 0141-0289 43.283 µM -0.243960912593042 0.42447408478938 no 1957 0.403630546300655 2930 352408 SGTC_911 3456-4043 236 µM -0.245083611565121 0.424028195549598 no 1958 0.40319584605158 2934 914281 SGTC_1093 fluphenazine 7.97 µM -0.246321776766691 0.423536560705444 no 1959 0.402716576879024 2851 6602611 An atypical antipsychotic. SGTC_305 1682-2595 20.8 µM -0.246504059382035 0.423464192281681 no 1960 0.402646031222066 2904 226033 SGTC_2764 methyldopa 94.69 µM -0.247236225034008 0.423173539614047 no 1961 0.40236270589553 3009 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent. SGTC_1208 2323-2347 50.3 µM -0.247663376095302 0.423003989916654 no 1962 0.402197435402728 3005 5412760 SGTC_3245 9134821 49.47 µM -0.24843098400975 0.422699338039728 no 1963 0.401900481529807 2852 17014901 SGTC_1860 st056228 74.6 µM -0.248552427392093 0.422651143243894 no 1964 0.401853505589253 2959 688679 SGTC_2924 9010168 62.78 µM -0.249318194690392 0.422347275253731 no 1965 0.401557329141261 2938 2993929 SGTC_126 0417-1624 672.48 µM -0.252452967077072 0.421103834061444 no 1966 0.400345481873159 2933 41912 YDL195W SEC31 SGTC_1741 st038134 10.228 µM -0.253759334333599 0.420585880907264 no 1967 0.399840745875369 3086 1272587 SGTC_2090 5301565 104.445 µM -0.254227951014863 0.42040011554452 no 1968 0.399659729011675 2867 2056344 SGTC_3334 9142812 21.919 µM -0.254361309048989 0.420347254033325 no 1969 0.399608219520575 2986 45283678 SGTC_338 4055-0136 114 µM -0.254949323706113 0.420114189282717 no 1970 0.39938111992622 2857 2900563 SGTC_2858 9025781 8.96 µM -0.255453481622791 0.41991438418428 no 1971 0.399186434097471 2958 4894980 YPL153C RAD53 SGTC_613 3914-0030 117 µM -0.255538047950582 0.41988087134151 no 1972 0.399153780383694 2796 1145395 SGTC_1615 st002656 86.5 µM -0.255970520108909 0.419709495768019 no 1973 0.398986800343897 2832 1584458 SGTC_1441 4106-0040 13 µM -0.25657997215278 0.41946801429881 no 1974 0.3987515187153 2856 2904180 SGTC_2144 5628481 200 µM -0.256590377010152 0.419463891874475 no 1975 0.398747502193746 2859 2818399 SGTC_1421 4029-0249 71.4 µM -0.257072957156978 0.41927270241974 no 1976 0.398561226608268 3024 2894095 SGTC_588 3970-1144 52.9 µM -0.25740685335424 0.4191404299874 no 1977 0.398432356441799 2988 1888707 SGTC_1565 sinapyl alcohol 95.1 µM -0.2608899350765 0.417761160463908 no 1978 0.397088693390988 2947 5280507 A phenol propionate derived from cinnamic acid. SGTC_1232 0279-0259 161 µM -0.260973023569441 0.417728270436084 no 1979 0.39705665531507 2888 1560000 SGTC_3158 9100007 49.47 µM -0.261203530496068 0.417637028814379 no 1980 0.396967777831438 2894 19297233 SGTC_2665 lovastatin 100 µM -0.262089954543613 0.417286196686208 no 1981 0.396626045637231 2895 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1 SGTC_348 k064-0012 10.7 µM -0.262533729423033 0.417110582568166 no 1982 0.396454992352693 2825 5066323 SGTC_27 0485-0001 32.618 µM -0.263018308733363 0.416918839884568 no 1983 0.396268233737956 2842 2054479 SGTC_1144 3486-0183 12.5 µM -0.263532487139966 0.416715406774685 no 1984 0.396070093552258 2878 6744069 SGTC_2126 5251174 33.877 µM -0.265177359362214 0.416064768170604 no 1985 0.395436417678896 3031 790722 SGTC_166 k072-0058 166.424 µM -0.265228564127424 0.416044517514977 no 1986 0.395416695817038 2947 5846229 SGTC_1688 st021091 57.6 µM -0.265389682325537 0.415980799330511 no 1987 0.395354641800157 2996 3656366 SGTC_1370 2001-0092 44.6 µM -0.265697579805037 0.415859039785787 no 1988 0.395236063723077 3094 790957 SGTC_2779 methotrexate 400 µM -0.266095341538564 0.415701754946106 no 1989 0.395082891310993 2962 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2 SGTC_870 0573-2213 57.6 µM -0.266453459947897 0.415560157609717 no 1990 0.39494499884939 2859 3916321 SGTC_456 gingerol 170 µM -0.268123144961548 0.414900121673537 no 1991 0.394302265388733 3059 442793 A herb. SGTC_2883 9059145 45.46 µM -0.269109928986366 0.414510153144656 no 1992 0.39392254498478 2820 16476510 SGTC_666 0272-0154 136 µM -0.269670425197919 0.414288687372366 no 1993 0.393706907560853 2918 6870312 SGTC_1035 k081-0041 55.2 µM -0.2702825420354 0.414046856157939 no 1994 0.393471447577564 3030 731709 SGTC_303 1348-1668 34.2 µM -0.2727795473442 0.413060693780642 no 1995 0.392511341199899 2907 5380509 SGTC_2963 9082507 9 µM -0.273411657124035 0.412811136314684 no 1996 0.392268396479658 3052 16459611 SGTC_1790 st045711 43.5 µM -0.273983395489699 0.412585443877609 no 1997 0.392048691033029 3055 585119 SGTC_2723 salbutamol 83.58 µM -0.27493688321745 0.412209121053154 no 1998 0.391682364976394 2991 9884233 β2-adrenoceptor agonist SGTC_562 3772-2733 112 µM -0.276462806798397 0.411607037138688 no 1999 0.391096311344462 3008 2876874 YIL048W NEO1 SGTC_1309 pyrazolanthrone 13.4 µM -0.277436702782654 0.41122287553056 no 2000 0.390722401260026 2988 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14 SGTC_33 0986-0033 35.816 µM -0.27772199278575 0.411110356548342 no 2001 0.390612888339919 2890 2848082 SGTC_552 k242-0005 476 µM -0.277969372074909 0.411012795551165 no 2002 0.390517935049082 3024 4088318 SGTC_3020 9089140 49.47 µM -0.278043331235298 0.410983628739568 no 2003 0.390489548064379 2985 17217859 SGTC_2331 7980721 200 µM -0.280707434003365 0.409933332532882 no 2004 0.389467403207385 2954 2981221 SGTC_91 0417-1751 58.384 µM -0.281899206937603 0.409463696457162 no 2005 0.389010398829113 2859 6795624 SGTC_2183 6420625 130.508 µM -0.282862177814432 0.409084318124304 no 2006 0.388641244359702 2892 2897619 SGTC_1375 2910-0797 186 µM -0.28458372568516 0.408406298209989 no 2007 0.38798154046726 2963 742508 SGTC_2920 7982904 15.77 µM -0.285831915145455 0.407914878571299 no 2008 0.387503431340408 3021 6456808 SGTC_2380 9035439 200 µM -0.285881732262799 0.407895268275396 no 2009 0.387484352821234 3056 6462575 SGTC_1419 3993-2473 62.6 µM -0.28613566731705 0.407795311410404 no 2010 0.387387107242502 2934 704026 SGTC_795 0685-0265 78 µM -0.286681403141433 0.407580512854517 no 2011 0.387178139154482 2905 302754 SGTC_1789 tunicamycin 25 nM -0.286803634218866 0.407532407194654 no 2012 0.387131340045646 3037 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_2030 5175110 200 µM -0.286866234691951 0.407507770489012 no 2013 0.387107372583606 3036 2831986 SGTC_3289 9119912 71.43 µM -0.288101468629213 0.407021713408603 no 2014 0.386634534231395 3012 17014829 SGTC_3108 9121785 49.47 µM -0.291079121899403 0.405850614741726 no 2015 0.385495403613205 2834 17140271 SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM -0.291626390528737 0.405635467557098 no 2016 0.385286147689405 3031 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair. SGTC_2029 5175081 200 µM -0.292264936696981 0.40538447255743 no 2017 0.385042032721024 2902 1380876 SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM -0.292975212038615 0.405105328493775 no 2018 0.384770549348745 2850 4000243 SGTC_2483 5729050 27.16 µM -0.293252347201068 0.404996425174713 no 2019 0.384664637306634 3094 2865180 SGTC_2373 9071805 200 µM -0.293997527157171 0.40470363499981 no 2020 0.384379896480423 3062 10149009 SGTC_1297 1068-0111 14.1 µM -0.294209866578001 0.404620214045028 no 2021 0.384298770844902 2926 767057 SGTC_3067 9117431 49.47 µM -0.294372160113108 0.404556457343788 no 2022 0.384236768977358 2950 17150885 SGTC_3179 9107801 49.47 µM -0.294935809024551 0.404335048654198 no 2023 0.384021458185121 2916 4818259 SGTC_3042 9091578 49.47 µM -0.295922681726115 0.403947465922225 no 2024 0.383644564454432 2972 25236497 SGTC_696 1560-0013 611 µM -0.297595762203424 0.40329059869313 no 2025 0.383005854691588 3131 1650269 SGTC_3340 9146634 11.102 µM -0.2988864551148 0.402784046714782 no 2026 0.382513341119457 3008 4907387 SGTC_173 1273-0061 2.693 µM -0.299208572645777 0.402657652217425 no 2027 0.382390454364844 3032 2847414 YPL266W DIM1 SGTC_3 0833-0587 95.581 µM -0.299937431427196 0.402371695610123 no 2028 0.382112440926291 2986 5382644 SGTC_1024 4507-0395 26 µM -0.300518433467106 0.4021437857437 no 2029 0.381890868987652 3095 4201836 SGTC_2830 7992007 71.43 µM -0.300707716101029 0.402069542961397 no 2030 0.381818692187214 2790 1952075 SGTC_138 0850-0259 40.9225 µM -0.301779651356982 0.401649161957965 no 2031 0.381410021980996 3018 6813004 SGTC_729 4092-0585 94.1 µM -0.302962665292453 0.401185351309436 no 2032 0.380959157008534 2923 2169061 SGTC_1664 st014217 9.02 µM -0.304276334611115 0.400670479257405 no 2033 0.380458686582363 2981 3982782 SGTC_4 0960-0234 25.671 µM -0.304430785036299 0.400609956156765 no 2034 0.380399858514039 3026 6821112 SGTC_2809 7964133 12.99 µM -0.304601096732314 0.400543220408662 no 2035 0.38033499230989 2982 1253665 SGTC_2696 st077691 74.316 µM -0.30586425470377 0.400048349297234 no 2036 0.379854001528581 3103 757133 SGTC_2958 9077254 16.72 µM -0.305974630052309 0.400005114834496 no 2037 0.379811981140525 3144 16457351 SGTC_2057 5236571 38.335 µM -0.306247437225377 0.399898260439938 no 2038 0.379708128320848 3118 54684039 YBR257W POP4 SGTC_2853 9015042 58.44 µM -0.306457300738007 0.399816065214098 no 2039 0.379628242932828 2871 6457456 SGTC_702 1488-0190 94 µM -0.306537573186663 0.399784626848786 no 2040 0.379597688261424 3034 949357 SGTC_222 nsc-310342 10.666 µM -0.307098900127041 0.399564803690058 no 2041 0.379384047427916 3022 432556 SGTC_145 3737-0113 38.366 µM -0.307696389641766 0.399330853759082 no 2042 0.379156683592773 3074 6849351 SGTC_676 falcarinol 140 µM -0.30794558174789 0.399233292052655 no 2043 0.379061870387624 3139 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer. SGTC_2762 leflunomide 42.06 µM -0.308409160666064 0.399051812079412 no 2044 0.378885506139343 2940 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1 SGTC_2303 7774051 200 µM -0.308483803015356 0.399022593437003 no 2045 0.378857111513922 3139 2953184 SGTC_2325 6158266 200 µM -0.30878600098383 0.398904304252157 no 2046 0.378742159354205 3020 3623240 SGTC_2108 5365811 200 µM -0.308860640123409 0.398875089724079 no 2047 0.378713769251907 3050 780283 SGTC_736 0958-0254 92.6 µM -0.308879360812182 0.398867762342515 no 2048 0.378706648663297 3061 6812352 SGTC_6 0844-0013 19.835 µM -0.309796589325289 0.39850879770955 no 2049 0.378357822715354 3023 1584900 SGTC_769 0302-0231 76 µM -0.309944973377625 0.398450734497051 no 2050 0.378301400928462 3060 571869 YER009W NTF2 SGTC_1793 st048256 72.231 µM -0.310106614433145 0.398387486329886 no 2051 0.378239941230665 2920 672022 SGTC_821 1114-0266 29.2 µM -0.316599173966188 0.395849251124224 no 2052 0.375773881320943 3036 3123235 SGTC_3167 9103034 49.47 µM -0.318423395221286 0.395136869517113 no 2053 0.37508189713712 2972 5127859 SGTC_948 3448-0295 75.3 µM -0.318661111451048 0.395044064056881 no 2054 0.374991753485095 2950 678569 SGTC_2714 st079313 56.9 µM -0.31916748201652 0.394846394619429 no 2055 0.374799757005397 2965 2939799 SGTC_2649 anisomycin 9.56 µM -0.319940387025961 0.39454473161355 no 2056 0.374506760629097 3023 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_2680 butyl paraben 22.24 µM -0.320166958140471 0.39445631341681 no 2057 0.374420884735593 2996 7184 An antifungal and steroid mimetic. SGTC_1216 1165-0504 9.65 µM -0.32031003296784 0.394400482011697 no 2058 0.374366659148658 3094 6304004 SGTC_1825 st052143 62.6 µM -0.321507620175 0.393933238467656 no 2059 0.373912869243624 3146 674173 SGTC_788 1182-0090 188 µM -0.322179266535389 0.393671259657798 no 2060 0.373658445336521 3166 5715185 SGTC_872 0588-0139 234 µM -0.322667583841455 0.393480819408949 no 2061 0.373473502194532 2968 2047100 SGTC_2814 7977482 42.97 µM -0.323018951876401 0.393343804154399 no 2062 0.373340444639244 3129 6456762 SGTC_2385 9074692 200 µM -0.323184832351616 0.393279123987258 no 2063 0.373277633555565 3010 17046906 SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM -0.323355122299497 0.393212727541122 no 2064 0.373213156315999 2988 689007 SGTC_1304 1165-0502 251 µM -0.325787414377253 0.39226471110635 no 2065 0.372292600785061 2995 767425 SGTC_376 3970-0862 59.1 µM -0.32603272226481 0.392169134654986 no 2066 0.372199798906406 3094 3135186 SGTC_425 3825-7017 13.1 µM -0.326065036804283 0.392156544802616 no 2067 0.372187574618333 3215 3397440 SGTC_344 k064-0035 6.43 µM -0.326460497364243 0.392002481197752 no 2068 0.372037986023537 2978 5088750 SGTC_54 0159-0055 9 µM -0.326953589437315 0.391810406007217 no 2069 0.37185149397014 3216 3319099 SGTC_3161 9100388 49.47 µM -0.329013714693095 0.39100820679873 no 2070 0.371072660900669 3005 25236368 SGTC_2544 sphondin 68.51 µM -0.329227374913606 0.390925035387156 no 2071 0.370991916525916 3178 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31 SGTC_1868 st057644 42.7 µM -0.329808363353853 0.390698899533035 no 2072 0.37077238380282 2961 688665 SGTC_2774 tamoxifen 10.92 µM -0.329972824720707 0.390634893588545 no 2073 0.370710247944283 2972 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  SGTC_2046 4110841 106 µM -0.330281042432588 0.390514947771405 no 2074 0.370593807963114 3149 44119630 YMR134W ERG29 SGTC_2354 9060492 162 µM -0.330418025300878 0.390461642945286 no 2075 0.370542061715074 3141 6471895 SGTC_3202 9113761 49.47 µM -0.332924705755005 0.389486570410461 no 2076 0.369595559874737 3142 4798415 SGTC_1770 st043884 66.3 µM -0.333159001736419 0.389395467157992 no 2077 0.36950713191374 2961 670149 SGTC_2562 3',7'-dimethoxyflavone 64.92 µM -0.333829549843227 0.389134765977523 no 2078 0.369254091887686 3079 688664 SGTC_1819 st053448 58.6 µM -0.335167327050239 0.38861480320102 no 2079 0.368749433614842 3001 2857616 SGTC_1796 st049173 110.4 µM -0.335593902054304 0.388449045359551 no 2080 0.368588561522344 3106 94134 SGTC_3081 9117243 49.47 µM -0.33581959119852 0.388361355642806 no 2081 0.368503457820086 3164 45595589 SGTC_1947 st076332 61.6 µM -0.336537232853161 0.38808255953538 no 2082 0.368232889714941 3100 24208416 SGTC_2910 7948405 25.97 µM -0.336548798282914 0.388078066961427 no 2083 0.368228529805351 3164 2971328 SGTC_3283 9109332 35.8195 µM -0.337211990654989 0.387820475945527 no 2084 0.367978549445915 3011 17027281 SGTC_3146 9095609 49.47 µM -0.337780660262691 0.387599637886073 no 2085 0.367764242528477 3051 17173999 SGTC_156 3474-0145 5.642 µM -0.338149736404111 0.38745632972249 no 2086 0.367625175756435 3059 2265471 SGTC_418 lividomycin a 100 µM -0.338409945620594 0.387355302590865 no 2087 0.367527140142016 3147 72394 An antibiotic. SGTC_1308 1187-1617 41.4 µM -0.340074776060902 0.386709107199815 no 2088 0.366900108356167 2998 2882570 SGTC_232 clozapine 119 µM -0.340935393548745 0.386375185926119 no 2089 0.366576109584755 3003 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_1210 3013-0140 750 nM -0.340995804856175 0.386351749377585 no 2090 0.36655336995985 3129 905973 SGTC_1911 st060208 74.3 µM -0.342090130009725 0.385927278123751 no 2091 0.366141532491364 3110 688783 SGTC_2848 9016370 25.97 µM -0.343353137396022 0.385437547474412 no 2092 0.365666404929353 3124 7894410 SGTC_1282 0886-0010 32.4 µM -0.344412566695228 0.3850268949451 no 2093 0.365268019734807 3192 2836211 YNL267W PIK1 SGTC_2627 acetyl isogambogic acid 100 µM -0.344461477800508 0.385007939291821 no 2094 0.365249630829541 3094 6857789 A caspase activator and apoptosis inducer. SGTC_1692 fluoroquinolonic acid 71 µM -0.344616663424139 0.384947798432786 no 2095 0.365191288385738 3118 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2 SGTC_42 0133-0086 60.653 µM -0.344785682469362 0.384882299698626 no 2096 0.365127748780334 2944 162923 Model of phenazepam hydroxylation. SGTC_2216 7189485 200 µM -0.345341399513051 0.384666969837732 no 2097 0.364918863274625 3121 731273 SGTC_2583 asiatic acid 100 µM -0.345546415602989 0.384587538953728 no 2098 0.364841810992338 3190 5320556 A kinase inhibitor; arrests cells at G2/M. SGTC_2930 9013230 14.89 µM -0.346148804953733 0.384354178882517 no 2099 0.364615443405818 3146 2995857 SGTC_1899 st063254 59.6 µM -0.347829086831739 0.383703474927491 no 2100 0.363984271952864 2981 3093813 SGTC_2181 6316240 54.2555 µM -0.347944781559422 0.38365868316725 no 2101 0.363940826600922 3100 12779990 SGTC_1261 0712-0010 12.7 µM -0.348165020627968 0.383573420868477 no 2102 0.363858127892069 3207 2840123 SGTC_3204 9114183 49.47 µM -0.348825699373615 0.383317682696878 no 2103 0.363610084263605 2963 17027248 SGTC_1251 0490-5699 265 µM -0.350246855479445 0.382767748321185 no 2104 0.363076722691056 3202 3883818 SGTC_2813 7971799 71.43 µM -0.350899654730261 0.382515218494921 no 2105 0.362831815260758 3121 2234054 SGTC_2251 lansoprazole 556 µM -0.351057254184812 0.382454259970334 no 2106 0.362772697863876 2987 3883 Gastric proton pump inhibitor. YBR192W RIM2 SGTC_3258 9138477 49.47 µM -0.351355304016259 0.382338984045619 no 2107 0.362660904832183 3055 4970355 SGTC_354 2783-3500 4.88 µM -0.351407575694672 0.382318768144783 no 2108 0.362641299889518 3037 6740761 SGTC_3302 9125395 16.351 µM -0.351456746201644 0.382299751904647 no 2109 0.36262285839658 3055 17599668 SGTC_1798 st045719 60.953 µM -0.353264019700251 0.381601002865948 no 2110 0.361945258451647 3106 3980186 SGTC_87 0100-0052 35.5 µM -0.353810489466645 0.381389796220859 no 2111 0.361740455942546 3143 200187 YGR083C | YDR527W GCD2 | RBA50 SGTC_626 0214-0009 33 µM -0.354067957387578 0.381290298952071 no 2112 0.361643977449754 3156 3437874 SGTC_848 0368-0089 85.6 µM -0.355374426536383 0.3807855411292 no 2113 0.361154552410106 3142 762535 SGTC_3132 9126706 49.47 µM -0.355871878083098 0.380593402675947 no 2114 0.360968258478679 3218 850858 SGTC_1006 4099-6547 255 µM -0.356028664850962 0.380532850583865 no 2115 0.360909549194133 3125 3146833 SGTC_1641 st009299 47.1 µM -0.356332091260508 0.380415673601557 no 2116 0.360795939556499 3115 4046054 SGTC_18 0111-0177 500 nM -0.359151498837592 0.379327402865 no 2117 0.359740878787894 3059 721752 SGTC_1592 4',5'-dihydroxyflavone 8.85 µM -0.359512521017401 0.379188119770185 no 2118 0.35960585633103 3059 688669 SGTC_430 0958-0115 16.4 µM -0.360029180871486 0.378988818626222 no 2119 0.359412655801998 3051 6833180 SGTC_336 4111-0029 111 µM -0.360944692674223 0.378635739678071 no 2120 0.359070396283003 3055 3131175 SGTC_3005 9076496 71.4286 µM -0.361053469512857 0.378593795211679 no 2121 0.359029738115855 3135 21368410 SGTC_1499 4480-0877 67.3 µM -0.362588141119257 0.378002176823463 no 2122 0.358456285142479 3040 2861909 SGTC_2660 2',4'-dihydroxychalcone 17.14 µM -0.364196128833056 0.377382601764907 no 2123 0.357855778765781 3151 5357218 A potent inhibitor of glutathione S-transferases. SGTC_1658 st012944 20 µM -0.364318411202296 0.377335497932473 no 2124 0.357810126526494 3125 24207260 SGTC_533 1222-0222 6.71 µM -0.366616704666725 0.376450522992963 no 2125 0.356952473034284 3217 3982874 SGTC_919 tnp00227 403.569 nM -0.36730173569721 0.376186872059536 no 2126 0.356696979768457 3050 1269246 A methoxyflavone. YNL221C POP1 SGTC_289 k017-0060 526 µM -0.367550764226834 0.376091041655107 no 2127 0.356604116525349 3067 5512909 SGTC_898 1000-0849 28.3 µM -0.369054812188707 0.375512421079337 no 2128 0.356043434857788 3137 6751807 SGTC_69 0096-0274 206.684 µM -0.36933944595122 0.375402951407948 no 2129 0.355937363557321 3329 6741392 SGTC_1927 st060202 13.8 µM -0.37012261871867 0.375101796266299 no 2130 0.355645564838249 3170 688887 SGTC_2796 7949634 45.45 µM -0.372008636137375 0.37437687456174 no 2131 0.354943209688088 3025 2971588 SGTC_2745 rifampicin 24.3 µM -0.372261410157469 0.374279750400621 no 2132 0.35484911372785 3106 25141428 Inhibits bacterial DNA-dependent RNA polymerase. SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM -0.372329866554491 0.37425344855536 no 2133 0.354823632132305 3244 551469 SGTC_446 go6976 132 µM -0.37257366235534 0.374159783766674 no 2134 0.354732889044811 3176 3501 A protein kinase C inhibitor. SGTC_1256 0570-0116 285 µM -0.372906968816674 0.374031741574799 no 2135 0.354608842586102 3075 410638 SGTC_633 0437-0093 97.7 µM -0.373318490762926 0.373873671486918 no 2136 0.354455707988557 3075 2831118 SGTC_2315 7733312 200 µM -0.374150816360922 0.373554030960714 no 2137 0.354146056834504 3047 726316 SGTC_407 eburnamonine 100 µM -0.374831215724441 0.37329279972098 no 2138 0.353892998605925 3027 3195 SGTC_355 1311-2252 105 µM -0.374955059602118 0.373245257598005 no 2139 0.353846944783959 3074 5338538 SGTC_195 4234-0266 16.654 µM -0.374957562743059 0.373244296693251 no 2140 0.353846013963001 3093 2303354 SGTC_2525 harmine 47.85 µM -0.375073313212819 0.373199863309921 no 2141 0.353802971810411 3079 5280953 A monoamine oxidase inhibitor SGTC_1239 0337-0584 35.4 µM -0.37525029484883 0.373131928246731 no 2142 0.353737164281566 3229 914301 YML130C ERO1 SGTC_1484 3473-2379 286 µM -0.375495178931244 0.373037935080179 no 2143 0.353646115621972 3138 671917 SGTC_1493 4348-0038 111 µM -0.375885676607071 0.372888067093163 no 2144 0.353500944698603 3155 800424 SGTC_682 0kpi-0099 17 µM -0.376038020885996 0.372829604532622 no 2145 0.353444315158294 3153 1714895 YML126C ERG13 SGTC_946 3434-1334 87.4 µM -0.379765651653446 0.371400031030292 no 2146 0.352059690745957 3194 4047976 SGTC_1007 4101-0031 70 µM -0.380162509982358 0.371247937014457 no 2147 0.351912393228055 3209 1146276 SGTC_1662 st014054 52 µM -0.380851298801476 0.370984009805023 no 2148 0.351656795861791 3104 2838777 SGTC_92 0063-0024 660.874 µM -0.381850575223168 0.370601219157974 no 2149 0.351286101240139 3112 3594437 SGTC_295 k015-0027 31 µM -0.382513751467272 0.370347248348534 no 2150 0.351040165414324 3141 3887424 SGTC_2896 9052656 71.43 µM -0.382841418021178 0.370221785602189 no 2151 0.350918674815556 3161 6469436 SGTC_2502 avocadyne acetate 18.59 µM -0.383298816458891 0.370046671915814 no 2152 0.350749108351549 3017 3952079 SGTC_1990 st072050 59.8 µM -0.383309831808186 0.370042455052805 no 2153 0.350745025114554 3055 17233948 SGTC_165 k038-0023 64.381 µM -0.383404374286785 0.370006263226976 no 2154 0.350709980239848 3081 46368543 SGTC_1923 st058458 19.1 µM -0.384249856760799 0.369682655119808 no 2155 0.350396634477251 3280 3534982 SGTC_2532 xanthone 78.9 µM -0.384898907686265 0.369434293712795 no 2156 0.350156157608444 3184 7020 An insecticide. SGTC_2547 epiafzelechin trimethyl ether 100 µM -0.385723417464333 0.369118870983312 no 2157 0.349850758920071 3118 6708630 An antioxidant. SGTC_3298 9116858 71.43 µM -0.386045136208936 0.368995818820956 no 2158 0.349731620522105 3213 2506942 SGTC_958 1222-0007 33 µM -0.388793075675706 0.367945325148406 no 2159 0.348714611728567 3246 7312461 SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM -0.389286083880109 0.367756960115836 no 2160 0.348532264744734 3184 17037758 SGTC_2873 9040596 71.43 µM -0.389308884163401 0.367748249516479 no 2161 0.348523832540927 3204 6463863 SGTC_130 0136-0219 337.655 µM -0.389383513638914 0.367719738615708 no 2162 0.348496232927162 3040 234244 SGTC_838 0109-0203 71.4 µM -0.389528092073298 0.367664506998656 no 2163 0.348442766939149 3099 759422 SGTC_2436 5633522 8.09 µM -0.390505630392704 0.367291141268771 no 2164 0.348081346349104 3259 5724242 SGTC_205 1486-1330 71.903 µM -0.390857343904263 0.367156836770737 no 2165 0.347951342714725 3107 4118834 SGTC_176 1486-1328 72.834 µM -0.391446759427439 0.366931800388264 no 2166 0.347733517516534 3139 22310231 SGTC_154 3389-1638 511.116 µM -0.391470335646855 0.366922800036679 no 2167 0.347724805701784 3145 5238686 SGTC_1924 st058459 75.1 µM -0.393652451922187 0.366090082435812 no 2168 0.346918825218104 3176 688683 SGTC_80 0159-0065 512.242 µM -0.394382266481986 0.365811718294325 no 2169 0.346649417184855 3193 1548079 SGTC_3197 9113331 49.47 µM -0.395722850763325 0.365300579941556 no 2170 0.346154748126338 3307 16610459 YLR208W | YDL195W SEC13 | SEC31 SGTC_1447 4239-0816 81.9 µM -0.395944245598595 0.365216189443342 no 2171 0.346073079733492 3101 1341554 SGTC_1761 st044296 37 µM -0.395999664086391 0.365195066241835 no 2172 0.34605263801524 3064 1826700 SGTC_1500 4488-1866 171 µM -0.397867839471266 0.364483235849682 no 2173 0.345363803785835 3233 2900003 SGTC_2052 5265182 7.135 µM -0.398462360378709 0.364256803551754 no 2174 0.34514469910405 3239 1239884 SGTC_834 0312-0008 75.7 µM -0.401382216925164 0.36314542091236 no 2175 0.344069370022565 3117 6385573 YIL048W NEO1 SGTC_2922 7999257 32.47 µM -0.402502106661455 0.362719463143415 no 2176 0.343657269139176 3178 2988377 SGTC_1931 st074438 57.1 µM -0.402688915483775 0.362648425635528 no 2177 0.343588544646905 3154 2787313 SGTC_1803 st050068 52.4 µM -0.402727691507525 0.362633680928135 no 2178 0.343574280109023 3209 3984059 YIL048W | YNL267W NEO1 | PIK1 SGTC_2290 7904846 200 µM -0.402759142623648 0.362621721689981 no 2179 0.343562710348903 3175 2962154 SGTC_2399 5884133 200 µM -0.402926445857288 0.36255810714771 no 2180 0.343501167833485 3112 722445 SGTC_697 0508-1955 564 µM -0.404998033913125 0.361770731747952 no 2181 0.342739478068363 3277 6243113 SGTC_135 0933-0004 26.348 µM -0.405759020032967 0.361481640557826 no 2182 0.342459835935191 3234 21230617 YGL099W LSG1 SGTC_607 4491-0986 66.8 µM -0.405982578691464 0.361396727825676 no 2183 0.34237770048255 3243 698981 YDR232W HEM1 SGTC_2462 5162487 171.77 µM -0.406294746431972 0.361278170744228 no 2184 0.342263022525104 3212 2259986 SGTC_1779 st039427 55 µM -0.407386235834531 0.360863742633687 no 2185 0.341862167311153 3328 1124498 SGTC_2902 5787006 60.46 µM -0.408167516151769 0.360567198207578 no 2186 0.341575347420043 3079 591003 SGTC_2569 tetrandrine 100 µM -0.409149478466755 0.360194601411616 no 2187 0.341214983834561 3149 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_2541 muurolladie-3-one 83.07 µM -0.409332308437573 0.360125242868336 no 2188 0.341147904299157 3290 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils.  YMR203W TOM40 SGTC_988 1497-1057 103 µM -0.410021474691746 0.3598638415378 no 2189 0.340895097283859 3256 3533044 SGTC_1783 st039459 87.517 µM -0.414204651808238 0.358278569073638 no 2190 0.339362117662345 3320 729761 SGTC_2911 7942208 15.64 µM -0.415090832052575 0.35794305114549 no 2191 0.33903770529972 3212 1243384 SGTC_1671 st016596 74.5 µM -0.416795418140104 0.357297984094658 no 2192 0.338414027042884 3177 2829167 SGTC_1118 chelidonine 707.474 nM -0.418818926277074 0.35653275646354 no 2193 0.337674235908935 3241 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor. SGTC_1634 st006576 41 µM -0.419980003743998 0.356093933591611 no 2194 0.33725003076483 3313 3915356 SGTC_2928 9011484 9.79 µM -0.421392927847195 0.355560183717937 no 2195 0.336734091262485 3255 2994751 SGTC_1137 ixabepilone 100 µM -0.422413283862513 0.355174907368265 no 2196 0.336361691765086 3170 154225 A novel microtubule stabilizer. SGTC_2907 7721985 69.9 µM -0.423735022986905 0.354676051805951 no 2197 0.335879535046123 3210 3267881 SGTC_782 0083-0095 30.5 µM -0.424539047787653 0.354372715662391 no 2198 0.335586367156302 3106 3591729 An indicator and reagent. SGTC_3307 9126885 69.2785 µM -0.425633496824908 0.353959958998297 no 2199 0.33518746402459 3145 24824909 SGTC_2432 5630864 12.22 µM -0.427146785756485 0.353389525217898 no 2200 0.334636208871901 3271 5714970 SGTC_1735 st034310 56.75 µM -0.429230242010744 0.352604705803608 no 2201 0.33387783835731 3314 871153 SGTC_2271 7849410 118.62 µM -0.429905239253223 0.352350574659471 no 2202 0.33363228706999 3303 972430 SGTC_2447 5741742 33.78 µM -0.431462143141346 0.351764664086119 no 2203 0.333066186581107 3253 1776504 SGTC_2674 ligustilide 100 µM -0.431984788712477 0.351568055386824 no 2204 0.332876234386705 3243 5319022 A signalling regulator. SGTC_1693 xanthone 101.9 µM -0.433111955611145 0.351144173175135 no 2205 0.332466718797762 3191 7020 An insecticide. SGTC_731 3966-0296 387 µM -0.433645359687986 0.350943645819168 no 2206 0.332272995240252 3149 660956 SGTC_216 k038-0035 28.382 µM -0.434052073731329 0.350790774064799 no 2207 0.332125313515598 3225 4444231 YPR107C YTH1 SGTC_1651 st011928 86.1 µM -0.434099453575041 0.350772966956134 no 2208 0.332108111140136 3259 720198 SGTC_2157 5649910 96.377 µM -0.434967581981179 0.35044675005689 no 2209 0.331792979206101 3149 2858091 SGTC_3346 9158254 43.5805 µM -0.436720291327443 0.349788470160063 no 2210 0.331157105821877 3230 17639500 SGTC_2061 5245884 80.95 µM -0.437340916578117 0.349555484767496 no 2211 0.330932062929208 3156 573863 SGTC_2746 daunorubicin 9.88 µM -0.437690542405771 0.349424258669782 no 2212 0.3308053131406 3201 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_1043 0916-0009 19.3 µM -0.437766098640998 0.34939590228825 no 2213 0.33077792430031 3346 3101130 SGTC_214 4373-3496 70 µM -0.438928511942409 0.348959752653709 no 2214 0.330356668270129 3284 3779166 SGTC_1479 0549-0158 134 µM -0.439532315891615 0.348733277773109 no 2215 0.330137935811233 3226 5440202 SGTC_220 paclitaxel 373.376 µM -0.441386655427275 0.348038089000844 no 2216 0.329466550680098 3256 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_2478 5763493 32.33 µM -0.442154305605709 0.347750447488044 no 2217 0.329188774689167 3160 1365576 YLR208W SEC13 SGTC_359 0081-0058 15.9 µM -0.443733022742447 0.347159171543509 no 2218 0.32861780867048 3505 3494159 SGTC_1367 1812-0510 76.9 µM -0.444207985107201 0.346981356885307 no 2219 0.328446109811257 3227 1142582 YDR527W RBA50 SGTC_823 0417-1665 178 µM -0.446431162924749 0.346149500240944 no 2220 0.327642913271496 3243 3429856 SGTC_2489 cantharidin 73.42 µM -0.446581953363312 0.346093105109225 no 2221 0.327588464054905 3259 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_457 grayanotoxin iii 135 µM -0.446687216778776 0.346053738958395 no 2222 0.327550456453853 3280 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity. SGTC_530 4358-1714 28 µM -0.446742336838912 0.346033125958759 no 2223 0.327530554893497 3252 1564641 SGTC_1866 st057638 64 µM -0.448121460594087 0.345517529935129 no 2224 0.327032770336037 3197 688802 SGTC_1217 1183-1422 255 µM -0.448133207790442 0.345513139384587 no 2225 0.32702853159196 3313 2849664 SGTC_611 3453-1652 23.7 µM -0.448645174869819 0.345321810322451 no 2226 0.326843820054814 3301 1560575 SGTC_739 1486-1183 203 µM -0.449164328529753 0.345127835893829 no 2227 0.326656559005621 3309 4346692 SGTC_183 3914-0051 30.55 µM -0.449939710445942 0.344838201168099 no 2228 0.326376956592555 3311 1596232 SGTC_786 4544-0069 423 µM -0.450983218882653 0.344448554471773 no 2229 0.326000821835142 3265 748821 YLR208W SEC13 SGTC_149 3970-0822 46.1 µM -0.451626646474807 0.344208380424971 no 2230 0.325768985219481 3326 3114250 YBL034C STU1 SGTC_2013 4024628 200 µM -0.4525180596832 0.343875743903108 no 2231 0.325447906985749 3323 5230760 SGTC_1929 genistein trimethyl ether 50.5 µM -0.453319434485718 0.343576808895657 no 2232 0.325159370222816 3366 136420 SGTC_2009 4012297 12.05 µM -0.454781650878677 0.343031613798089 no 2233 0.32463316616013 3276 45595307 SGTC_1695 st026914 34.495 µM -0.455073554273241 0.342922815152326 no 2234 0.324528161491829 3192 3289191 SGTC_1180 1193-0155 285 µM -0.455148931036395 0.342894722734038 no 2235 0.324501048923631 3308 2921347 SGTC_340 k038-0059 454 µM -0.45547537754538 0.342773068319406 no 2236 0.324383638817326 3280 23733424 SGTC_2501 sodium tetradecyl sulfate 13.37 µM -0.455523294125543 0.342755212972394 no 2237 0.324366406556956 3160 23665772 A membrane-active detergent. SGTC_517 1365-0151 113 µM -0.456061497387862 0.342554684275777 no 2238 0.324172878131545 3346 768657 SGTC_1031 k035-0009 16 µM -0.458392969321476 0.341686516137822 no 2239 0.323335070938208 3340 5180959 SGTC_2834 9001755 58.44 µM -0.459256311721055 0.341365246132751 no 2240 0.323025058387034 3181 2989575 SGTC_16 erodoxin 22.806 µM -0.46115052073799 0.340660769384291 no 2241 0.322345308863976 3333 3967339 Erodoxin inhibits Ero1. YML130C ERO1 SGTC_1426 4048-4480 71.7 µM -0.461236881701838 0.340628664032192 no 2242 0.322314331788879 3316 14224343 SGTC_2074 5212007 75.395 µM -0.461276345771578 0.34061399334529 no 2243 0.322300176713186 3306 758611 SGTC_1813 st051246 8.6015 µM -0.461528181574896 0.340520379582232 no 2244 0.322209853658383 3279 5291959 SGTC_2857 9024691 58.44 µM -0.462045677304084 0.340328044120116 no 2245 0.322024282363677 3280 16478292 SGTC_2578 7,8-dihydroxyflavone 64.44 µM -0.462961423575239 0.339987794343927 no 2246 0.321696009224911 3155 1880 Intensifies effect of antibiotics on Staphylococcus aureus. SGTC_3011 9081274 71.4286 µM -0.464116184585289 0.339558923290213 no 2247 0.321282253403872 3215 6625322 SGTC_2629 bisabolol 100 µM -0.464918473756386 0.339261080308568 no 2248 0.320994920244501 3351 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer. SGTC_1984 st072354 53.1 µM -0.465562315571346 0.33902213215701 no 2249 0.320764411175208 3159 5762938 SGTC_491 tetrandrine 80.3 µM -0.467522801154309 0.338294938831469 no 2250 0.320062941387788 3286 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_331 k048-0133 24.5 µM -0.467533175114733 0.338291092469928 no 2251 0.32005923124962 3229 6813582 SGTC_2140 5586273 200 µM -0.468149235752137 0.338062705447577 no 2252 0.31983893589792 3308 854421 SGTC_2803 7707263 71.43 µM -0.470255786083212 0.337282212273524 no 2253 0.319086141008991 3194 2199229 SGTC_1721 st082152 9.2685 µM -0.470358978854276 0.337243996506057 no 2254 0.319049283264755 3262 5296051 SGTC_727 3032-0951 202 µM -0.472794767411679 0.336342430125309 no 2255 0.318179803790716 3264 3652836 SGTC_644 1498-1197 63.3 µM -0.472906019258161 0.336301274531307 no 2256 0.318140115180998 3337 6741615 SGTC_708 3448-5400 146 µM -0.473937572670379 0.335919763612125 no 2257 0.31777221250116 3327 3462195 SGTC_547 1120-0019 610 nM -0.474003461143549 0.33589540108028 no 2258 0.317748719537597 3257 3676939 SGTC_1668 st014914 51.6 µM -0.474922402499881 0.335555690674653 no 2259 0.317421141532396 3330 2839556 SGTC_1862 st057513 3.81 µM -0.475008035076067 0.335524041221497 no 2260 0.317390623087219 3197 5393163 SGTC_659 k018-0002 107 µM -0.476454889601224 0.334989466242107 no 2261 0.316875168928689 3349 6797879 YHR007C ERG11 SGTC_3324 9138759 60.749 µM -0.476851003391509 0.334843170750454 no 2262 0.316734111942623 3343 45595710 SGTC_2520 obtusaquinone 4.71 µM -0.478060328205256 0.334396689651373 no 2263 0.316303633631889 3400 5967872 SGTC_1780 st038448 24.544 µM -0.478172402886612 0.334355323675398 no 2264 0.316263751464802 3379 728868 YDL195W SEC31 SGTC_2661 dactinomycin 12.96 µM -0.478203976493456 0.334343670442472 no 2265 0.316252516272302 3263 45006140 An Actinomycin D Classic transcription inhibitor. SGTC_11 0438-0307 1.3 µM -0.478625423479337 0.334188137464228 no 2266 0.316102564287258 3340 4011476 SGTC_299 1273-0059 1.44 µM -0.479707268500796 0.333789018153801 no 2267 0.315717779397051 3307 2848077 SGTC_1707 st032323 6.317 µM -0.480466913352996 0.333508878740355 no 2268 0.315447712238031 3297 3132057 YMR211W DML1 SGTC_2533 agelasine 13.65 µM -0.481652275542731 0.333071930098584 no 2269 0.31502649196643 3443 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase. SGTC_2870 9038528 12.99 µM -0.48332390711459 0.332456117717809 no 2270 0.314432883819759 3352 6463316 SGTC_1812 st052057 4.327 µM -0.484006972570915 0.332204613196034 no 2271 0.31419046036392 3248 3645418 SGTC_2491 paeonol 100 µM -0.486161755183672 0.33141171835131 no 2272 0.313426242416088 3327 11092 Increases levels of cortical cytochrome oxidase. SGTC_14 0354-0009 295 µM -0.487430520282345 0.330945204078201 no 2273 0.31297663467376 3266 1713507 SGTC_370 0180-0345 38.7 µM -0.487605255179719 0.330880976063307 no 2274 0.312914736258757 3200 3989527 SGTC_2121 5257820 149.641 µM -0.487984835398146 0.330741469376429 no 2275 0.312780291229261 3375 791256 SGTC_1989 st071868 50.2 µM -0.491216115203633 0.329554834233082 no 2276 0.311636801095095 3368 16414057 SGTC_3136 9095672 49.47 µM -0.492116945325914 0.329224324001354 no 2277 0.311318336868931 3278 17217380 SGTC_3071 9117417 49.47 µM -0.492662027272544 0.329024400833427 no 2278 0.311125706358849 3236 45595590 YGL055W OLE1 SGTC_1081 sertraline 6 µM -0.493457431371113 0.328732753166899 no 2279 0.310844705483597 3386 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1 SGTC_2 0422-0095 29 µM -0.493665289411858 0.328656555861539 no 2280 0.310771291428218 3279 6790840 SGTC_2504 purpurogallin 52.29 µM -0.494897361812316 0.328205044924683 no 2281 0.310336286520321 3233 5281571 An antioxidant. SGTC_2384 9036245 200 µM -0.495814706136251 0.327869033570639 no 2282 0.310012574099535 3282 6462766 SGTC_722 3534-0461 190 µM -0.496587075836007 0.327586232545441 no 2283 0.309740134453525 3316 658262 SGTC_3076 9116187 49.47 µM -0.497087572082643 0.327403030021103 no 2284 0.309563649099095 3334 27241210 SGTC_1402 3909-7673 35.9 µM -0.497134197681212 0.327385965220718 no 2285 0.30954721018119 3321 5328014 SGTC_321 4534-3890 65.3 µM -0.497420388208221 0.327281228426207 no 2286 0.309446315533672 3344 699746 SGTC_2607 solasodine 47.35 µM -0.497767696736784 0.327154142614854 no 2287 0.309323893414778 3272 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity. SGTC_1008 4106-0037 6 µM -0.497844737990511 0.327125954688122 no 2288 0.309296740158041 3325 2905394 SGTC_2198 6589944 200 µM -0.498725285765776 0.326803849111598 no 2289 0.308986464335602 3340 5290268 SGTC_2418 pentamidine 31.67 µM -0.498737904491259 0.326799234101826 no 2290 0.308982018905057 3378 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_3023 9089636 49.47 µM -0.500869668763476 0.326019970975101 no 2291 0.308231425106375 3429 17249241 SGTC_2025 5147754 141 µM -0.501561611043248 0.325767195591368 no 2292 0.307987964430422 3316 315777 YLR208W SEC13 SGTC_3237 9133362 49.47 µM -0.501566458327064 0.325765425098786 no 2293 0.307986259205985 3352 43845137 SGTC_1608 st001473 40.5 µM -0.501964231842025 0.325620149899013 no 2294 0.307846340719098 3268 7292267 SGTC_561 1550-0330 72.9 µM -0.501974452219956 0.32561641755229 no 2295 0.307842746026713 3276 6812934 SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM -0.502570982077171 0.325398603045229 no 2296 0.307632967611328 3296 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1 SGTC_161 4065-0411 162.148 µM -0.503551168200133 0.325040831336484 no 2297 0.307288407456789 3329 1906281 YLR208W SEC13 SGTC_353 1988-1175 58.3 µM -0.505017215157569 0.324506019601767 no 2298 0.306773372363859 3226 2788357 SGTC_1747 st037496 66.6 µM -0.505476261760341 0.324338634398162 no 2299 0.306612183609936 3272 723305 SGTC_1610 st001799 48.1 µM -0.506633958200125 0.323916653550512 no 2300 0.306205838419937 3230 621897 SGTC_1390 3413-2614 145 µM -0.507173642433916 0.323720015683171 no 2301 0.306016493572397 3338 3421432 SGTC_459 nigericin 15.3 µM -0.508927946273421 0.323081162478533 no 2302 0.305401365218596 3417 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification. SGTC_1323 1348-1351 11.2 µM -0.509926518453907 0.322717751846491 no 2303 0.305051471368635 3299 6989654 SGTC_2654 protoveratrine a 100 µM -0.510050810039236 0.322672530215663 no 2304 0.305007932784035 3318 5702278 A heart drug and vasodilator. SGTC_2249 haloperidol 116.36 µM -0.513390946925748 0.321458255528736 no 2305 0.303838938509113 3376 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_1067 clotrimazole 1.36 µM -0.513929905605179 0.321262500480048 no 2306 0.303650499037925 3323 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_1646 st011709 75.6 µM -0.514284429811544 0.321133760896149 no 2307 0.30352657299003 3396 5757843 SGTC_2918 7977171 22.06 µM -0.516165765360812 0.320450945085375 no 2308 0.302869319278907 3341 2236483 SGTC_269 exalamide 29 µM -0.517287850987657 0.320043981972297 no 2309 0.302477616815123 3312 3316 A derivative of salicylamide. SGTC_1012 4112-3522 18 µM -0.518137671401983 0.319735909242643 no 2310 0.302181109098705 3414 3112398 SGTC_46 0329-0187a 2.197 µM -0.518896462593574 0.319460941028779 no 2311 0.301916472355692 3357 46494817 SGTC_202 3594-0513 34.79 µM -0.519196537446984 0.319352228282051 no 2312 0.301811846701203 3345 708429 SGTC_1985 st071382 65.5 µM -0.520012862370251 0.319056564257654 no 2313 0.301527305122228 3400 6123237 SGTC_914 3820-6779 408 µM -0.52015079423597 0.319006618193308 no 2314 0.301479238945236 3287 2893481 SGTC_1047 2043-3044 82 µM -0.521654987320576 0.318462153149576 no 2315 0.300955285222893 3313 669592 SGTC_3078 9116413 49.47 µM -0.522088064255734 0.318305467109868 no 2316 0.300804508225318 3302 17177322 SGTC_1351 1496-0003 46.5 µM -0.522395372750513 0.318194303456204 no 2317 0.30069753855175 3422 3891978 SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM -0.523603340171051 0.317757500405851 no 2318 0.300277228916025 3372 1241132 A phosphatase inhibitor. SGTC_500 h-89 112 µM -0.527664052953999 0.316291001058917 no 2319 0.298866263589908 3463 449241 Protein kinase A inhibitor; also known to inhibit several other kinases. SGTC_3287 9117173 37.0625 µM -0.528901428269269 0.315844703570018 no 2320 0.298436915568906 3332 2789709 SGTC_188 3229-0966 278.469 µM -0.529286859785787 0.315705740609577 no 2321 0.298303234793534 3447 5722370 SGTC_1354 1498-1681 81 µM -0.529575424840582 0.315601718803721 no 2322 0.298203168455056 3403 5754243 SGTC_1950 st077106 7.18 µM -0.530241514024664 0.315361663050914 no 2323 0.29797224563737 3344 13831864 SGTC_1074 carmofur 3.8 µM -0.530411641384894 0.315300362351327 no 2324 0.297913278183593 3420 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_593 1203-0218 61.7 µM -0.530606168581241 0.315230276074665 no 2325 0.297845860078946 3442 3666956 SGTC_683 panaxydol 45 µM -0.530754141008027 0.315176967486147 no 2326 0.297794581315236 3408 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis. SGTC_1022 4477-0945 21.3 µM -0.531239699905683 0.315002066938627 no 2327 0.297626342718797 3378 4648966 SGTC_664 1222-0054 14.9 µM -0.533465543752574 0.314200839046595 no 2328 0.296855678286685 3406 6813991 SGTC_1037 k284-1091 78.7 µM -0.535185776036553 0.313582213085559 no 2329 0.296260700523052 3426 3334711 SGTC_573 3702-0553 84.7 µM -0.535869819159043 0.313336364563567 no 2330 0.296024262195589 3406 1222756 SGTC_1398 3558-0053 112 µM -0.537410762487817 0.312782845751019 no 2331 0.295491955374477 3296 4532369 SGTC_3061 glucosamine 200 µM -0.537742377856613 0.312663782056284 no 2332 0.295377459024023 3403 91431 and experimental redox chemotherapeutic SGTC_519 k048-0011 62.8 µM -0.539395656747982 0.312070478084783 no 2333 0.294806938642352 3397 6836379 SGTC_1440 4100-1550 40 µM -0.539795117722992 0.311927198526556 no 2334 0.294669167220707 3405 742806 SGTC_127 0180-0333 59.125 µM -0.540223590439254 0.31177354460096 no 2335 0.294521422862111 3436 771601 SGTC_3191 9110352 49.47 µM -0.540625231960651 0.311629542313492 no 2336 0.294382961385061 3415 17122424 SGTC_2229 7354935 190 µM -0.541220001274796 0.311416349987971 no 2337 0.294177976459859 3390 318112 SGTC_577 r071-0003 38.6 µM -0.54280783830749 0.310847506944279 no 2338 0.293631057925147 3389 4568517 YMR134W ERG29 SGTC_2519 cryptotanshinone 88.04 µM -0.543602786524982 0.310562886141101 no 2339 0.293357420922603 3460 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE) SGTC_2694 st077685 81.9 µM -0.544935195864232 0.310086088714653 no 2340 0.292899044301513 3334 2838096 SGTC_3201 9113999 49.47 µM -0.547227243127144 0.309266635634675 no 2341 0.292111310937173 3442 16649224 SGTC_184 1494-0393 24.714 µM -0.547577415528272 0.309141525310842 no 2342 0.291991050173472 3339 3090647 SGTC_2570 licareol 100 µM -0.548412444928458 0.308843273600433 no 2343 0.291704366576305 3380 443158 SGTC_2807 7945238 51.95 µM -0.548548483872892 0.308794695808648 no 2344 0.291657673903308 3423 17148797 SGTC_2293 7624732 200 µM -0.548748220170768 0.308723378556342 no 2345 0.291589124688992 3404 894453 SGTC_1717 st033143 58.0435 µM -0.548944455962309 0.308653318209006 no 2346 0.291521784160048 3497 674616 SGTC_1849 st056239 19.2 µM -0.549130855161767 0.308586776183635 no 2347 0.291457825886197 3332 5393181 SGTC_3355 9151058 44.0485 µM -0.549421475153579 0.30848304126739 no 2348 0.291358119886242 3447 17015728 SGTC_1372 2752-0194 270 µM -0.55016894001015 0.308216308780848 no 2349 0.291101752541854 3439 823334 SGTC_2475 5812728 15.03 µM -0.550941270489808 0.307940809350618 no 2350 0.290836967448526 3429 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2 SGTC_1090 efavirenz 20.7 µM -0.551346158676339 0.307796424163366 no 2351 0.290698200942025 3441 64139 A non-nucleoside reverse transcriptase inhibitor. SGTC_431 k089-0097 107 µM -0.551859024382201 0.307613576364196 no 2352 0.290522471987189 3388 5499420 SGTC_969 1313-0238 134 µM -0.553046207398805 0.307190503129246 no 2353 0.290115884939109 3360 5212874 SGTC_3335 9143315 29.6265 µM -0.554366797484766 0.306720189332202 no 2354 0.289663922118348 3373 4899691 SGTC_2220 6782180 200 µM -0.55551799478931 0.306310462338763 no 2355 0.289270202624497 3403 833803 SGTC_535 2293-4129 48.2 µM -0.556277515988168 0.306040270783763 no 2356 0.289010577561146 3486 396118 YIL048W NEO1 SGTC_1627 st003713 25.6 µM -0.557199347617808 0.30571248074897 no 2357 0.28869561770363 3427 16195070 YER133W GLC7 SGTC_3145 9085516 49.47 µM -0.557234561252789 0.305699962372333 no 2358 0.288683589556894 3423 25236195 SGTC_1427 4048-4900 550 nM -0.558759185568582 0.305158179391656 no 2359 0.288163040333448 3464 24132586 SGTC_3039 9090270 49.47 µM -0.559159860335193 0.305015868333727 no 2360 0.288026312322566 3494 17173750 SGTC_2757 clomiphene 4.22 µM -0.559441211087177 0.304915956217358 no 2361 0.28793032126483 3542 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined. SGTC_650 1328-0195 38 µM -0.559462377689947 0.304908440208978 no 2362 0.28792310026871 3448 2780821 SGTC_1778 st046819 58.9 µM -0.561176729748403 0.304299967767753 no 2363 0.287338532415741 3396 671715 SGTC_1534 6-azauridine 81.6 µM -0.562685767133977 0.303764815275849 no 2364 0.286824438856165 3415 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1 SGTC_1038 k292-0204 154 µM -0.563017647576068 0.303647176308155 no 2365 0.286711433498415 3416 4454212 SGTC_2938 9059746 27.26 µM -0.56332336290185 0.303538829875977 no 2366 0.286607356050218 3428 6471769 SGTC_2084 5306078 60.6385 µM -0.564067602403515 0.303275141358916 no 2367 0.286354062765282 3360 679340 SGTC_2238 6671620 73.2395 µM -0.5648169305287 0.303009753414448 no 2368 0.286099145029913 3436 729941 SGTC_1942 st076330 65.2 µM -0.565104040919057 0.3029080956831 no 2369 0.286001500067633 3526 24208414 SGTC_2473 5854593 8.94 µM -0.565767017018912 0.302673412802992 no 2370 0.285776085387964 3401 2872951 SGTC_105 0111-0055 734.78 µM -0.566087234282713 0.302560090222976 no 2371 0.285667240434652 3436 5179370 SGTC_1365 1672-3266 55.4 µM -0.56684316798139 0.30229264620764 no 2372 0.285410369512382 3483 6415873 SGTC_3003 9075612 71.4286 µM -0.567464965490302 0.302072738168755 no 2373 0.285199161375177 3455 6501993 SGTC_326 k292-0812 17.5 µM -0.567660621551437 0.302003556321506 no 2374 0.285132717604844 3448 3579357 SGTC_2689 tacrolimus 100 µM -0.567825920532876 0.301945113952654 no 2375 0.285076588689878 3428 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). SGTC_991 3996-0057 64.7 µM -0.568753310199718 0.301617324465495 no 2376 0.284761782012161 3432 715343 SGTC_333 3486-0131 40.1 µM -0.571179030400329 0.300760702045824 no 2377 0.283939145589051 3542 6744690 SGTC_1000 4048-0884 8.67 µM -0.571700042469912 0.300576854379115 no 2378 0.283762602832294 3481 13040088 SGTC_1983 st071813 46.9 µM -0.572257645286032 0.300380151298597 no 2379 0.283573719701347 3435 11838595 SGTC_1570 verbenone 133 µM -0.573539606609908 0.299928140200717 no 2380 0.283139694989843 3514 29025 A natural terpanoid with antifungal properties. SGTC_22 0964-0034 14.468 µM -0.574103267304617 0.299729494643357 no 2381 0.282948961253958 3455 138402 SGTC_3338 9144300 39.5675 µM -0.575039848057082 0.299399556265906 no 2382 0.282632173833509 3419 4901274 SGTC_3232 9132874 49.47 µM -0.575533037321991 0.299225881927397 no 2383 0.282465426912603 3421 3784940 SGTC_25 0118-0223 35.662 µM -0.575955275574641 0.299077228994131 no 2384 0.282322706076174 3517 5333628 SGTC_1286 0929-0070 131 µM -0.576348981856168 0.298938651222008 no 2385 0.282189660602421 3523 1420408 SGTC_723 4182-0001 115 µM -0.577243751793471 0.298623816263851 no 2386 0.281887402573772 3410 744821 YLR208W SEC13 SGTC_1040 k898-0338 155 µM -0.577888603387691 0.29839701144566 no 2387 0.281669665050793 3542 20969351 SGTC_1956 st077085 54 µM -0.57892895762148 0.298031267268087 no 2388 0.281318555030789 3447 24208685 SGTC_453 enantio-paf c16 10 µM -0.580554986834948 0.297460034313006 no 2389 0.280770208593035 3499 13871343 A lipid and platelet activating factor SGTC_2213 7173844 200 µM -0.581877564540514 0.29699577459745 no 2390 0.28032457674534 3451 892728 SGTC_225 nsc-122657 1.016 µM -0.581893035528671 0.296990345833621 no 2391 0.28031936594868 3449 275685 SGTC_892 0929-0076 29 µM -0.582007778519424 0.296950083978885 no 2392 0.280280720728709 3445 5751038 SGTC_1033 k072-0102 21.3 µM -0.582225659751253 0.296873639101878 no 2393 0.280207345849323 3505 5965931 SGTC_2616 abietic acid 100 µM -0.582783464830527 0.296677971051312 no 2394 0.280019538771014 3517 6708678 Abietic acid is an inhibitor of 5α-reductase. SGTC_389 tpck 16.7 µM -0.584025025864077 0.296242665795873 no 2395 0.279601737482752 3460 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.  SGTC_1636 st007707 68.9 µM -0.585835721342752 0.295608341322886 no 2396 0.278992958125461 3559 403051 SGTC_3215 9129942 49.47 µM -0.586027768452111 0.295541099846027 no 2397 0.278928427226412 3467 17682944 SGTC_182 3448-4371 550.524 µM -0.586172933806312 0.29549027775129 no 2398 0.278879654165891 3521 3491403 SGTC_1132 3456-3614 2.5 µM -0.586391932030289 0.295413614525724 no 2399 0.27880608238503 3554 3125502 SGTC_467 ro 31-8220 72.8 µM -0.587712351315704 0.294951578303296 no 2400 0.278362691865224 3409 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7 SGTC_2868 9035608 32.47 µM -0.590017728762572 0.294145688380909 no 2401 0.277589381869322 3504 6462614 SGTC_2423 st077119 87.2 µM -0.591282242230444 0.293704085434389 no 2402 0.277165662895653 3470 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae). SGTC_3246 9135460 32.98 µM -0.59182225581866 0.293515591352399 no 2403 0.276984809139099 3459 41446951 SGTC_952 1185-0122 232 µM -0.593522639779472 0.292922431220815 no 2404 0.276415718090013 3482 678600 SGTC_1755 st041960 45.185 µM -0.594347239756133 0.292634979087504 no 2405 0.27613994442249 3502 2257073 SGTC_3123 9126162 49.47 µM -0.595837336303073 0.292115870238839 no 2406 0.275641949348769 3524 25239884 SGTC_3297 9117502 71.43 µM -0.596183711825857 0.291995263904651 no 2407 0.275526252811681 3502 7453720 SGTC_2983 9022671 12.99 µM -0.597990353505693 0.291366575883622 no 2408 0.274923184852412 3533 6405161 SGTC_2307 7538926 6.34 µM -0.598633879943505 0.291142789636394 no 2409 0.274708529040227 3472 96582 SGTC_2645 abamectin 100 µM -0.598797635633317 0.291085856427056 no 2410 0.274653919597713 3514 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels. SGTC_1134 3477-0009 42.5 µM -0.600914961297127 0.290350191068068 no 2411 0.273948313850497 3594 3973534 SGTC_1350 1495-0454 146 µM -0.601606372834004 0.290110148656003 no 2412 0.273718092906751 3556 1069057 SGTC_1326 1431-2094 10.8 µM -0.601894509498196 0.290010141600409 no 2413 0.273622179615816 3478 616278 SGTC_3060 1327-0027 12.5 µM -0.602219343831797 0.289897416828192 no 2414 0.273514070559092 3451 16000455 YPR107C YTH1 SGTC_2265 7929201 200 µM -0.603536165134706 0.289440661041013 no 2415 0.27307603213404 3490 1265108 SGTC_2043 5101342 149 µM -0.603632560144948 0.289407238520046 no 2416 0.2730439801571 3453 678451 SGTC_2458 5808907 16.39 µM -0.604250885733742 0.289192892957682 no 2417 0.272838427176108 3611 2731747 SGTC_627 1391-0720 175 µM -0.606824381944148 0.288301580740194 no 2418 0.271983732735567 3466 997839 SGTC_38 0929-0051 58.268 µM -0.607311993772793 0.28813284592139 no 2419 0.271821940142637 3499 1379719 SGTC_146 3448-8650 53.125 µM -0.607376790669781 0.288110426895589 no 2420 0.271800443740524 3521 2891488 YIL048W NEO1 SGTC_657 3534-0529 86.7 µM -0.609629750959797 0.287331439338663 no 2421 0.271053549547015 3536 1049549 SGTC_1483 3453-0561 55.9 µM -0.609658764685691 0.287321414003654 no 2422 0.271043937690107 3537 4546991 SGTC_1966 st070145 16.1 µM -0.609953939501756 0.287219429395976 no 2423 0.27094615991052 3482 3748532 SGTC_1281 0884-0031 11.8 µM -0.61312709248446 0.286124170253298 no 2424 0.269896153753327 3539 1548255 SGTC_53 0973-0023 39.979 µM -0.61326982144372 0.286074951977749 no 2425 0.269848972212383 3553 674768 SGTC_2575 plumbagin 510 nM -0.613968577397418 0.285834052902337 no 2426 0.269618045883264 3498 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_2999 9069765 71.4286 µM -0.614980540279683 0.285485345521445 no 2427 0.26928378588767 3506 2097066 SGTC_2257 7960413 200 µM -0.615623556743765 0.285263876881001 no 2428 0.269071500087742 3528 2974689 YIL048W NEO1 SGTC_164 4100-3994 89.624 µM -0.615908947743859 0.285165608343065 no 2429 0.268977307866967 3598 4615967 SGTC_1445 4239-0156 97.7 µM -0.616088463153488 0.285103804160389 no 2430 0.268918067966148 3596 4008346 SGTC_2283 7944793 200 µM -0.616694821965533 0.284895092085919 no 2431 0.268718018625629 3517 2970533 SGTC_2756 carbadox 75.1 µM -0.617132167817724 0.284744600469059 no 2432 0.268573776309298 3516 2553 A substituted quinoxaline antibiotic. YLR208W SEC13 SGTC_468 gf-109203x 121 µM -0.619189144071986 0.284037300003237 no 2433 0.267895881311594 3468 2396 A protein kinase C inhibitor. SGTC_3120 9124077 49.47 µM -0.620371736533787 0.283631041185752 no 2434 0.267506537867842 3568 18774327 YGL155W CDC43 SGTC_1830 st055982 50.3 µM -0.620968430361036 0.283426163240235 no 2435 0.267310197463219 3531 455313 An antimicrobial agent. SGTC_2964 9083345 53.42 µM -0.621072570526331 0.283390413442519 no 2436 0.267275937892234 3481 17741579 SGTC_858 0438-0351 2.77 µM -0.621367378970427 0.28328922173368 no 2437 0.267178965129798 3534 2799119 SGTC_2441 5730946 39.09 µM -0.62155274396038 0.283225604886385 no 2438 0.267118001225146 3564 1774275 SGTC_1554 st069299 38.7 µM -0.622103898978467 0.283036490216084 no 2439 0.26693677568432 3549 24207999 SGTC_273 hydroxyurea 18.1 mM -0.622312590291521 0.282964898982199 no 2440 0.266868172009302 3597 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12 SGTC_2717 st081029 62.2815 µM -0.622583131549061 0.282872103162619 no 2441 0.266779249491412 3537 5292846 SGTC_390 dec-rvkr-cmk 16.7 µM -0.622621246788367 0.282859030786473 no 2442 0.266766722834736 3553 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1 SGTC_1117 retinoic acid 1.10837 µM -0.622873510793815 0.282772519165584 no 2443 0.266683823213263 3588 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR). SGTC_236 1509-0011 5.31 µM -0.623603995549261 0.282522077858547 no 2444 0.266443842983543 3625 3107280 SGTC_1681 tripelennamine 100 µM -0.623732721074588 0.282477956317165 no 2445 0.26640156515576 3556 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist. SGTC_2285 7945142 200 µM -0.624166661759119 0.282329244639939 no 2446 0.266259069329986 3565 2970608 SGTC_1087 pterostilbene 9.05 µM -0.624362586434058 0.282262113506072 no 2447 0.266194744959015 3579 5281727 Similar to reservatol, lowers cholesterol. SGTC_602 3130-1533 38.1 µM -0.62504740552257 0.282027529195617 no 2448 0.265969972636963 3583 720941 SGTC_1471 k673-0312 37 µM -0.625202079222546 0.281974558826394 no 2449 0.265919218723326 3553 24099884 SGTC_74 000s-0487 160.283 µM -0.627560584779761 0.281167446817015 no 2450 0.26514591800665 3542 677548 SGTC_1498 4478-3555 97.6 µM -0.629459156518437 0.280518541930218 no 2451 0.264524249991115 3558 3437919 SGTC_2888 9058547 12.99 µM -0.629465371742791 0.280516418845526 no 2452 0.26452221609765 3501 16476514 SGTC_1824 st053723 68.6 µM -0.629763278298817 0.280414664810012 no 2453 0.264424737364529 3543 675225 SGTC_501 nsc-95397 161 µM -0.632232673220575 0.279571898080062 no 2454 0.263617425114922 3589 262093 SGTC_2685 mycophenolic acid 18.85 µM -0.632950521297334 0.279327138395719 no 2455 0.263382977225356 3524 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_3064 1327-0027 10 µM -0.633335929214117 0.279195771496838 no 2456 0.263257147628119 3476 16000455 YPR107C YTH1 SGTC_2082 5219693 150 µM -0.633453229998985 0.279155795300152 no 2457 0.263218856869932 3581 2834649 SGTC_686 1319-0111 510 µM -0.635855031569841 0.278337871860818 no 2458 0.262435457372549 3627 4562600 SGTC_2430 5571206 200 µM -0.63613198066114 0.278243633175924 no 2459 0.262345201262315 3618 1731771 SGTC_3156 9099931 49.47 µM -0.638227156964939 0.277531202779011 no 2460 0.26166291081701 3567 18111053 SGTC_3213 9129884 49.47 µM -0.640370023658509 0.276803479378954 no 2461 0.260966033208431 3517 17190742 SGTC_3181 9108277 49.47 µM -0.640503829485828 0.276758069576158 no 2462 0.260922550148425 3535 17097298 SGTC_804 1595-0054 20.9 µM -0.642297895375671 0.276149568594483 no 2463 0.260339890265716 3564 761523 Stimulates phospholipase C. SGTC_3057 9095946 49.47 µM -0.642871213759059 0.275955252308331 no 2464 0.260153834729829 3597 24540043 SGTC_1800 st050079 29.0735 µM -0.645220368712991 0.275159749189683 no 2465 0.259392194130478 3561 3645560 SGTC_301 4119-0100 24.5 µM -0.645276095944439 0.27514089178886 no 2466 0.259374140302323 3584 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1 SGTC_2919 7978188 46.38 µM -0.646815383597671 0.274620267730892 no 2467 0.258875717416057 3591 2980291 SGTC_155 k072-0202 43.6 µM -0.647131312796028 0.274513473017881 no 2468 0.258773480549689 3551 5857737 SGTC_1437 4092-1038 11.6 µM -0.647480431166501 0.274395483085202 no 2469 0.258660527747355 3588 3977136 SGTC_651 3253-0966 34.4 µM -0.649278029287207 0.273788353663121 no 2470 0.258079342091548 3591 781462 SGTC_2905 7799065 20.05 µM -0.649984242092038 0.27355001585593 no 2471 0.257851200200647 3540 1296806 SGTC_2311 7694451 200 µM -0.650082247223649 0.273516948490517 no 2472 0.257819547936038 3532 2163142 SGTC_2289 7946404 165.07 µM -0.653287931947902 0.27243642830119 no 2473 0.256785335503275 3638 1246120 YPR165W RHO1 SGTC_1665 st014639 11.4 µM -0.653773296926165 0.272273014327663 no 2474 0.256628936341344 3662 981133 YIL048W NEO1 SGTC_1751 st044839 27.194 µM -0.655505005559872 0.271690375233879 no 2475 0.256071332339767 3614 5291326 SGTC_1174 0739-0097 51.1 µM -0.655609929670452 0.27165509312204 no 2476 0.256037567466747 3614 728447 SGTC_1293 1000-1278 195 µM -0.65611144268181 0.271486484292209 no 2477 0.255876211258777 3650 678847 SGTC_2471 5466956 24.79 µM -0.65727513065736 0.271095452951413 no 2478 0.255502012188813 3562 724419 SGTC_1505 k297-0037 20.6 µM -0.657986889906701 0.270856420680354 no 2479 0.255273277697742 3577 4089396 SGTC_1414 3917-0015 5.4 µM -0.658161197688571 0.270797898407063 no 2480 0.255217277605357 3592 6618702 SGTC_3070 9117005 49.47 µM -0.658174653913177 0.270793380862882 no 2481 0.255212954773317 3638 8779016 SGTC_1069 diphenylcyclopropenone 8.49 µM -0.66039621961876 0.270048069654041 no 2482 0.254499798762102 3660 65057 A dermal irritant. YDR527W RBA50 SGTC_93 0109-0045 59.227 µM -0.661234393293967 0.269767138382022 no 2483 0.254231003940298 3669 88733 SGTC_257 daunorubicin 18.5 µM -0.662291886560777 0.269412906534719 no 2484 0.253892087781457 3652 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_2931 9014674 55.67 µM -0.662918247957193 0.269203202305156 no 2485 0.253691457015161 3613 2996810 SGTC_2096 5468907 200 µM -0.663202148696575 0.269108180022366 no 2486 0.253600547768499 3624 759785 SGTC_2899 9053889 58.44 µM -0.663382358100567 0.26904787222064 no 2487 0.253542850912138 3582 6470052 SGTC_2340 7987427 183.45 µM -0.663826083361005 0.268899406696486 no 2488 0.253400814738452 3589 2239331 SGTC_3053 9095903 49.47 µM -0.664840485976984 0.26856015347956 no 2489 0.253076262258449 3669 17174018 SGTC_2387 9077560 195.08 µM -0.665282921261198 0.268412254398038 no 2490 0.252934776066231 3602 5303272 SGTC_845 0330-0138 4.51 µM -0.665522092461471 0.268332320326638 no 2491 0.252858308947186 3593 9039800 SGTC_1176 0848-0131 83.3 µM -0.665882391245108 0.268211926477951 no 2492 0.252743138248048 3674 6769040 SGTC_1155 4088-0394 48.2 µM -0.6659699012472 0.268182689111281 no 2493 0.252715169555902 3596 2326248 SGTC_1807 st050092 58.9 µM -0.666410164748683 0.268035620027582 no 2494 0.252574483578375 3585 5008496 SGTC_1457 k015-0032 57.3 µM -0.666496795350711 0.268006686041247 no 2495 0.252546805672548 3623 4302660 SGTC_529 4076-0302 30.3 µM -0.667506229752129 0.267669658307679 no 2496 0.252224415867286 3599 5816522 SGTC_362 0310-0100 9.03 µM -0.668913232946205 0.267200247822566 no 2497 0.251775414188873 3652 790235 SGTC_3107 9121808 49.47 µM -0.669062181034844 0.267150579448912 no 2498 0.251727906715298 3576 662681 SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM -0.670516053892645 0.266666014495968 no 2499 0.251264437994231 3635 115019 SGTC_3083 9117465 49.47 µM -0.671445998935577 0.266356303933001 no 2500 0.250968224882048 3624 16420915 SGTC_1380 2291-0730 164 µM -0.67277668643358 0.265913446178877 no 2501 0.250544685881314 3616 2999191 SGTC_777 1315-0167 517 µM -0.672878477354706 0.265879585148938 no 2502 0.250512302871209 3597 4221767 SGTC_2324 6149169 200 µM -0.674003342499273 0.265505541209545 no 2503 0.250154594322758 3565 2888231 SGTC_2996 9066192 71.4286 µM -0.674044689606481 0.26549179741883 no 2504 0.25014145105408 3628 6472854 SGTC_89 0302-0250 142.109 µM -0.674490759476595 0.265343546617178 no 2505 0.249999679274407 3692 4203518 YLR208W SEC13 SGTC_2425 5628681 7.85 µM -0.67583172307745 0.264898132086763 no 2506 0.249573745525664 3646 5714958 SGTC_851 0394-0702 453 µM -0.675991755026138 0.264845001260065 no 2507 0.249522939924821 3639 762646 SGTC_1958 st076513 41.9 µM -0.676386993950379 0.264713804608766 no 2508 0.249397486335783 3602 732122 YGL099W LSG1 SGTC_55 0767-0285 6.563 µM -0.677388378179255 0.264381550495243 no 2509 0.249079785070126 3612 3116166 SGTC_1449 4112-4002 201 µM -0.678011873865106 0.264174785135306 no 2510 0.248882082333285 3611 2059539 SGTC_3337 9144342 33.5465 µM -0.678661780781305 0.263959348916453 no 2511 0.248676093866976 3639 17682949 SGTC_732 3970-1727 52.7 µM -0.67900344278156 0.263846128050905 no 2512 0.248567840274651 3641 1275699 SGTC_77 0828-0286 12.516 µM -0.680474334468949 0.263358982952156 no 2513 0.248102083746469 3627 745345 SGTC_1263 0774-1208 64.8 µM -0.680670821809334 0.263293943033905 no 2514 0.248039901473876 3682 906585 SGTC_3068 9116768 49.47 µM -0.682430797206084 0.262711733842794 no 2515 0.247483293734612 3618 41904888 SGTC_784 4579-0127 173 µM -0.682668337143668 0.262633204846456 no 2516 0.247408220786877 3720 1948547 SGTC_2115 tiliquinol 12.7705 µM -0.68449609587623 0.262029362986933 no 2517 0.246830976917255 3637 71208 A bioactive hydroxyquinoline. SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM -0.685216497594012 0.261791557502671 no 2518 0.246603657448484 3618 6857784 SGTC_2469 5655019 90.81 µM -0.68534391369821 0.261749508816655 no 2519 0.246563463553097 3686 2788239 SGTC_111 0083-0039 52.457 µM -0.685631144689843 0.261654732208509 no 2520 0.246472868317035 3573 759313 SGTC_670 4204-0025 119 µM -0.686788224829906 0.261273112960079 no 2521 0.246108095565286 3662 719039 SGTC_1700 st030840 7.9285 µM -0.686880180236627 0.261242797207121 no 2522 0.246079118791484 3675 5499307 SGTC_2437 5741531 144.16 µM -0.687236370711351 0.261125385801669 no 2523 0.2459668941538 3698 2262990 SGTC_1987 st072290 61.9 µM -0.688290391984629 0.260778106712352 no 2524 0.245634965475874 3661 54697379 SGTC_2070 5230947 200 µM -0.689896950781305 0.260249234983979 no 2525 0.245129496762822 3723 2835538 SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM -0.690719664426901 0.259978615606099 no 2526 0.244870864589348 3669 6708739 YPR165W RHO1 SGTC_178 4092-0806 87.505 µM -0.691389254885649 0.259758470986519 no 2527 0.244660477399591 3635 2169044 SGTC_691 1548-0686 185 µM -0.69257140614236 0.259370044152133 no 2528 0.244289279922567 3653 46495133 SGTC_1731 st035964 63 µM -0.692932360692454 0.259251502886017 no 2529 0.244176000115321 3654 6739575 SGTC_2010 4012422 159 µM -0.693543580553894 0.259050835731384 no 2530 0.243984243152821 3648 952393 SGTC_1501 4491-0275 38.4 µM -0.696220690878975 0.258172871582985 no 2531 0.243145315916547 3659 5104718 SGTC_2708 st078559 56 µM -0.696379484125258 0.258120843500042 no 2532 0.243095603855606 3607 17250902 SGTC_1333 1482-0047 286 µM -0.697150068111693 0.257868441427452 no 2533 0.242854441705617 3654 3811116 SGTC_3036 9090181 49.47 µM -0.700398507771455 0.256805836048393 no 2534 0.241839233961634 3691 25236586 SGTC_250 brefeldin a 552.239 µM -0.702087213009538 0.256254341086852 no 2535 0.241312388104392 3580 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.  SGTC_2309 7664088 163.95 µM -0.702883213171837 0.255994598754613 no 2536 0.24106426671349 3684 704922 SGTC_1980 st071811 45.7 µM -0.70291958179379 0.255982734613574 no 2537 0.241052933556818 3719 4974850 SGTC_3102 9121669 49.47 µM -0.704079752295214 0.255604415367769 no 2538 0.240691554363162 3702 41905072 SGTC_308 4092-1169 104 µM -0.704635893095263 0.255423167374689 no 2539 0.240518427785665 3648 2268590 YDL196W YDL196W SGTC_572 0960-0087 17.7 µM -0.705476871830375 0.255149217444913 no 2540 0.240256760034114 3694 6796365 SGTC_391 gliotoxin 8.33 µM -0.705591384002688 0.255111926843765 no 2541 0.240221141953568 3734 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion SGTC_3257 9139206 32.98 µM -0.706641408738944 0.254770121880163 no 2542 0.23989467449954 3669 4910041 SGTC_2995 9067767 71.4286 µM -0.707192723126203 0.254590753580535 no 2543 0.239723360039788 3684 11673567 SGTC_139 0099-0334 718.624 µM -0.708031447130313 0.254318004434669 no 2544 0.239462864506373 3730 97690 SGTC_386 1509-0011 3.07 µM -0.708074872761471 0.254303886793279 no 2545 0.239449381344011 3717 3107280 SGTC_2107 5363541 170.161 µM -0.708204717451402 0.254261676829053 no 2546 0.239409068524308 3652 244052 SGTC_2606 farnesol 9.78 µM -0.709736279427044 0.253764073374248 no 2547 0.238933845020789 3716 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_1551 6-bromo-3'-methylflavone 63.5 µM -0.710174283452403 0.253621860241299 no 2548 0.238798033056617 3722 688751 SGTC_2626 ethyl orsellinate 100 µM -0.71050773632207 0.253513621324129 no 2549 0.238694667600684 3680 75653 A natural product. SGTC_1883 5-benzylidenerhodanine 20 µM -0.711141202378724 0.253308064891005 no 2550 0.238498369944139 3685 1273210 SGTC_249 wiskostatin 11.211 µM -0.711400283241083 0.253224019755572 no 2551 0.238418111766933 3686 2775510 A n-wasp and actin depolymerizer. SGTC_2296 7971656 126.45 µM -0.712477340669602 0.252874782471694 no 2552 0.238084619057154 3742 666570 SGTC_2189 6047310 154.431 µM -0.713342424175278 0.2525944617121 no 2553 0.237816945747833 3642 711535 SGTC_867 0518-0118 155 µM -0.714578490905441 0.252194212159969 no 2554 0.237434769725668 3720 6848158 SGTC_1564 D-Arginine 115 µM -0.71474719282418 0.252139610909345 no 2555 0.237382635412158 3669 71070 D-isomer of arginine; arginine decarboxylase inhibitor. SGTC_900 1112-0045 141 µM -0.715795588962859 0.251800431890952 no 2556 0.237058788260126 3628 56211 YIL048W NEO1 SGTC_672 1441-0018 53.7 µM -0.716972839930907 0.251419852838724 no 2557 0.236695427714943 3686 251141 SGTC_865 0488-0499 301 µM -0.717473915450446 0.251257958555886 no 2558 0.236540862887676 3695 9634651 SGTC_1100 amiodarone 5.07 µM -0.71757975397014 0.251223769862365 no 2559 0.236508222395114 3751 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. SGTC_716 1683-5115 658 µM -0.718347673186477 0.25097578496193 no 2560 0.236271471136459 3717 723597 SGTC_2246 7293507 91.5585 µM -0.71837451860842 0.250967118087686 no 2561 0.236263196992754 3757 887656 SGTC_945 3381-0768 11.3 µM -0.72019051753908 0.250381202280939 no 2562 0.235703850737535 3708 1126236 YIL048W NEO1 SGTC_2145 5634607 200 µM -0.720275038179245 0.250353950122333 no 2563 0.235677835313185 3670 308662 SGTC_365 0121-0052 13.6 µM -0.720773685201902 0.250193202376783 no 2564 0.235524384165547 3728 3101739 SGTC_2495 cafestol 54.53 µM -0.721205548526681 0.250054027790724 no 2565 0.235391529258323 3707 16667697 An anti-infammatory. SGTC_1994 st072947 40.9 µM -0.721542908239098 0.249945337026821 no 2566 0.235287775453355 3737 5286565 YDL195W SEC31 SGTC_1975 st070967 30.8 µM -0.72156152563774 0.249939339591748 no 2567 0.235282050472415 3702 261391 SGTC_1394 3474-0001 65.7 µM -0.721875876724284 0.249838085622104 no 2568 0.235185396916726 3689 5017666 YIL048W NEO1 SGTC_1750 st081859 2.357 µM -0.722093070097475 0.249768139333414 no 2569 0.235118629261949 3716 5291695 SGTC_307 1501-1223 22.3 µM -0.723054788362277 0.249458546668967 no 2570 0.234823112236618 3688 2830329 SGTC_1544 7-methoxy-4-methylcoumarin 105 µM -0.724947852582747 0.248849734980729 no 2571 0.234242011274019 3684 390807 SGTC_2705 st078069 42.8 µM -0.725151037220439 0.248784437596412 no 2572 0.234179688418042 3720 1530061 SGTC_1223 0764-0573 147 µM -0.726000675339469 0.248511488516526 no 2573 0.233919178272343 3727 1609797 SGTC_270 tamoxifen 5.46 µM -0.727628871889867 0.247988871137624 no 2574 0.233420400910472 3777 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  YIL048W NEO1 SGTC_3043 9092303 49.47 µM -0.728387085681002 0.247745700499355 no 2575 0.233188333233741 3717 25236084 SGTC_2262 9014885 67.46 µM -0.729239630636684 0.247472428568525 no 2576 0.232927546505845 3658 6457424 SGTC_2439 5492030 7.2 µM -0.729822228938878 0.247285777127578 no 2577 0.232749427535144 3730 5722370 SGTC_2969 9091408 28.7 µM -0.730729549203732 0.246995241993673 no 2578 0.232472181450235 3693 4286311 SGTC_265 mycophenolic acid 32.932 µM -0.730871710488538 0.246949736753893 no 2579 0.232428758465302 3806 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1 SGTC_3230 9131665 49.47 µM -0.732469754928947 0.246438518144425 no 2580 0.231940948300918 3656 15943720 SGTC_2585 alliin 100 µM -0.733045807690924 0.246254376512746 no 2581 0.231765245535498 3777 87310 A garlic compound which reacts with lipids. SGTC_1604 st002052 72.4 µM -0.734597593390895 0.245758698312814 no 2582 0.231292302055999 3743 6254834 YHR062C RPP1 SGTC_2225 6654152 15.4 µM -0.734859724996936 0.24567502000172 no 2583 0.231212464417398 3658 97582 YGR029W | YLR033W ERV1 | RSC58 SGTC_2205 7238770 200 µM -0.736381518549705 0.245189531622759 no 2584 0.230749274360425 3746 279867 SGTC_2823 7987624 58.44 µM -0.736904070295693 0.245022944235998 no 2585 0.23059034430974 3739 2239440 SGTC_2846 9008642 19.48 µM -0.737146401118477 0.244945710818632 no 2586 0.230516662040095 3762 2992898 SGTC_1068 loratadine 26.9 µM -0.740721754445279 0.243807731457336 no 2587 0.22943108308562 3774 3957 A H1 histamine antagonist. SGTC_497 capsazepine 133 µM -0.741743002809366 0.243483208709399 no 2588 0.229121529946152 3733 2733484 A calcium channel blocker. SGTC_119 0121-0043 24.815 µM -0.744918459794227 0.242475634252 no 2589 0.228160507444087 3823 1092378 SGTC_1317 1273-0028 910 nM -0.745126440998602 0.242409720587043 no 2590 0.228097643048707 3736 5917803 YLR359W | YHR072W ADE13 | ERG7 SGTC_2625 euphol 100 µM -0.745743105173535 0.242214343674896 no 2591 0.227911307411618 3741 6708538 A triterpene alcohol. SGTC_1170 0310-0127 64.8 µM -0.746369210642736 0.242016062850464 no 2592 0.227722206574551 3760 774975 SGTC_3027 9089541 49.47 µM -0.746867778775383 0.241858234701827 no 2593 0.2275716886572 3730 9943819 SGTC_1458 k015-0034 6.33 µM -0.748147377722145 0.241453416935308 no 2594 0.227185633739994 3787 3598957 SGTC_871 0574-0004 149 µM -0.750898082684587 0.240584442990267 no 2595 0.226356997160441 3746 9551173 SGTC_416 estradiol valerate 100 µM -0.7510349518497 0.240541249227511 no 2596 0.226315810617236 3785 13791 A steroid. SGTC_3217 9129673 49.47 µM -0.751180734761737 0.240495247070281 no 2597 0.226271946413553 3747 17248312 SGTC_2450 5739737 12.93 µM -0.752157278957348 0.240187219710246 no 2598 0.225978240694611 3781 2262825 SGTC_875 0709-0210 25.7 µM -0.754133411518233 0.239564554601232 no 2599 0.225384558350333 3755 6251364 SGTC_2829 7992743 58.44 µM -0.75551839896784 0.239128680824207 no 2600 0.224968998471877 3817 16462845 SGTC_490 phenamil 164 µM -0.757292228562015 0.238571066936408 no 2601 0.224437402891913 3735 4755 Irreversibly blocks amiloride-sensitive Na+ channels. SGTC_987 1497-1013 404 µM -0.75788246358878 0.238385680974823 no 2602 0.224260674689077 3765 1676435 SGTC_99 0109-0120 622.8 µM -0.758426231777798 0.238214959547583 no 2603 0.22409792953799 3792 759414 SGTC_1979 st071809 45.3 µM -0.7591711121319 0.237981205723198 no 2604 0.223875102166751 3876 4976333 SGTC_3162 9099653 49.47 µM -0.760380695566902 0.237601889636052 no 2605 0.223513529498631 3721 25237511 SGTC_1583 clindamycin 39.6 µM -0.760682816679448 0.237507198581054 no 2606 0.223423270332028 3749 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis. SGTC_1382 3002-2117 298 µM -0.762424004531892 0.236961877896551 no 2607 0.222903491993703 3811 1497314 SGTC_2760 etidronate 98.04 µM -0.762460731813183 0.236950382736546 no 2608 0.222892535611646 3780 3305 A chelator and antioxidant. SGTC_990 3985-0011 41.3 µM -0.76284919351576 0.236828818059158 no 2609 0.222776669564785 3779 5399565 YGL099W LSG1 SGTC_636 0kpi-0074 126 µM -0.763529457737075 0.23661601973219 no 2610 0.222573850602685 3793 616434 SGTC_2221 6807166 181.081 µM -0.763721450482166 0.236555980145609 no 2611 0.222516627532933 3718 674925 SGTC_1123 mangostin 811.285 nM -0.765698031085605 0.235938355474032 no 2612 0.221927999436984 3809 5281650 An antioxidant. SGTC_3234 9132280 49.47 µM -0.765969384390751 0.235853634795192 no 2613 0.221847259566414 3811 17612295 SGTC_2321 7390090 138.78 µM -0.766055270538741 0.235826823312173 no 2614 0.22182170805213 3785 649046 SGTC_862 0452-0056 10.2 µM -0.76609589840776 0.235814140904555 no 2615 0.221809621664545 3724 1575396 YLR359W | YHR072W ADE13 | ERG7 SGTC_1066 ketoconazole 628 nM -0.769239767282543 0.234833891060147 no 2616 0.220875493366326 3838 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W SGTC_3312 9133330 71.43 µM -0.769587327159176 0.234725661257492 no 2617 0.220772362387606 3842 17617324 SGTC_96 0929-0093 37.281 µM -0.770517856504112 0.234436031143637 no 2618 0.220496383445154 3757 6991579 SGTC_323 4013-0906 34.3 µM -0.770889637659973 0.234320368426228 no 2619 0.22038617486847 3820 2910086 SGTC_1886 st057356 49.9 µM -0.77091486354331 0.234312521689723 no 2620 0.220378698202919 3776 24207747 SGTC_1611 st001856 99.4 µM -0.771807697886086 0.234034891273768 no 2621 0.220114165893167 3769 647478 SGTC_623 k072-0108 16.9 µM -0.771850692619197 0.234021526489094 no 2622 0.220101431850454 3790 5382803 SGTC_1169 aniline yellow 25.8 µM -0.772355714998232 0.233864573437429 no 2623 0.219951887571832 3728 6051 A DNA damaging agent. SGTC_3183 9108214 49.47 µM -0.773382703592615 0.233545581444434 no 2624 0.2196479616037 3735 4974831 SGTC_377 3970-0964 33.1 µM -0.774896576302269 0.233075799151038 no 2625 0.219200387690876 3776 16481235 SGTC_3046 9092212 49.47 µM -0.775341602245607 0.232937799349507 no 2626 0.219068916303385 3811 25236637 SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM -0.775970236255397 0.232742941175856 no 2627 0.218883279956697 3852 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_1617 st002906 78 µM -0.776402052697019 0.232609143198205 no 2628 0.218755816514889 3807 5150859 SGTC_66 0109-0187 42.4 µM -0.777134793534636 0.232382201910107 no 2629 0.218539624073855 3776 759417 SGTC_1099 5-nonyloxytryptamine 2.85 µM -0.777624000246023 0.232230755534474 no 2630 0.218395353975987 3775 23581825 A 5-HT1D beta serotonin receptor agonist. SGTC_1397 3532-0190 20.1 µM -0.777625084730189 0.23223041986585 no 2631 0.218395034215822 3713 5322280 SGTC_1088 bifonazole 369 nM -0.777781205770186 0.23218210023045 no 2632 0.21834900473958 3723 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase. SGTC_1327 1436-0082 2.18 µM -0.779419851345027 0.231675275308188 no 2633 0.217866216880601 3802 15992205 SGTC_1435 4092-0789 56.7 µM -0.77958441985044 0.231624409177796 no 2634 0.217817764735764 3795 2248285 SGTC_1192 1488-0095 21.4 µM -0.78043418044707 0.231361857547827 no 2635 0.217567677735183 3839 915875 SGTC_2298 7976326 193.81 µM -0.781470815838825 0.231041791834442 no 2636 0.217262817448724 3681 2235818 SGTC_1737 st035557 69.7 µM -0.781690606878496 0.230973962157974 no 2637 0.2171982116263 3704 5716916 SGTC_3282 9108498 15.4605 µM -0.783067937125104 0.23054915770218 no 2638 0.216793609138304 3816 16459645 SGTC_735 3076-0345 636 µM -0.783148933553689 0.230524189898802 no 2639 0.216769829323149 3846 2888990 SGTC_824 1304-0008 100 µM -0.783956592753995 0.230275305109211 no 2640 0.216532790443288 3833 768245 SGTC_2825 7998094 58.44 µM -0.785039552046413 0.229941820991708 no 2641 0.216215189565336 3809 2987815 SGTC_2782 7736369 71.43 µM -0.785223893722775 0.229885082154237 no 2642 0.216161154319868 3868 2950836 YOL077C BRX1 SGTC_1432 4049-0298 68.4 µM -0.786773951087704 0.229408297516358 no 2643 0.215707102426365 3812 741646 SGTC_744 1594-0068 283 µM -0.786936955016498 0.229358191102419 no 2644 0.215659386510034 3821 668392 SGTC_2288 7946289 167.31 µM -0.787227088441619 0.22926902103566 no 2645 0.215574471292767 3824 1246052 SGTC_2255 7941087 197.44 µM -0.787382715987178 0.229221198229759 no 2646 0.2155289307679 3817 935561 SGTC_1459 k035-0031 35.7 µM -0.788075160814397 0.229008484607512 no 2647 0.215326371690952 3671 3877128 YMR208W ERG12 SGTC_1976 st070609 63.5 µM -0.789722694131686 0.228502820788592 no 2648 0.214844867394473 3732 682556 SGTC_2388 9080168 200 µM -0.79176668045476 0.227876349631075 no 2649 0.214248366893514 3793 15943073 SGTC_1194 1488-0194 225 µM -0.792218304240805 0.227738059762623 no 2650 0.214116698721241 3771 1391452 SGTC_3155 9099265 49.47 µM -0.792888258249338 0.227533002928583 no 2651 0.213921464460614 3832 25236499 SGTC_3127 9126946 49.47 µM -0.793085427629665 0.227472673925089 no 2652 0.213864026204876 3820 27243249 SGTC_302 1094-0063 18.9 µM -0.79395449037228 0.227206869399664 no 2653 0.213610962864131 3777 5440289 SGTC_3056 9094900 49.47 µM -0.794138589482613 0.227150584807293 no 2654 0.213557377243076 3803 25236784 SGTC_2741 miltefosine 3.04 µM -0.794419968070965 0.227064574163507 no 2655 0.213475491677462 3771 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis. SGTC_2950 9072895 21.46 µM -0.795369928398031 0.226774329899844 no 2656 0.21319917359182 3765 17332245 SGTC_2784 7567673 72.73 µM -0.797163989707501 0.226226756279469 no 2657 0.212677898401111 3820 3471247 SGTC_3238 9133470 49.47 µM -0.797284374722997 0.226190039785393 no 2658 0.212642946483399 3806 3534688 SGTC_67 0335-0847 266 µM -0.797661746699716 0.226074966089134 no 2659 0.212533404136956 3993 4552207 YOR254C SEC63 SGTC_1091 telmisartan 47.6 µM -0.798224952585248 0.22590328680102 no 2660 0.212369979831048 3865 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension. SGTC_1310 1188-0297 994 nM -0.798378827107423 0.225856394810042 no 2661 0.212325343148841 3746 1588352 SGTC_2470 5664817 21.68 µM -0.799385912935785 0.22554962965531 no 2662 0.212033338111944 3856 2859561 SGTC_2002 4023503 131 µM -0.799781656986176 0.225429147909307 no 2663 0.211918656234189 3840 4736863 YCR052W RSC6 SGTC_2876 9059903 25.97 µM -0.799892754929754 0.225395331401656 no 2664 0.211886467907056 3768 6916095 SGTC_2472 5377652 49.4 µM -0.799996396776216 0.225363787005012 no 2665 0.211856442408394 3899 1610903 SGTC_1049 3226-0134 66 µM -0.80008312732432 0.225337391646538 no 2666 0.211831318100473 3868 5702385 SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM -0.800998913273803 0.225058790489045 no 2667 0.211566137488243 3885 6708561 SGTC_263 alizarin 107.927 µM -0.801043067911303 0.225045362662847 no 2668 0.211553356712916 3837 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. SGTC_1724 st037281 8.293 µM -0.801278316138288 0.22497382919409 no 2669 0.2114852705857 3841 574124 YDL195W SEC31 SGTC_743 1275-0778 158 µM -0.801880580605863 0.224790753434243 no 2670 0.211311020190244 3836 2849257 YMR203W TOM40 SGTC_1602 st001878 87.6 µM -0.803387980700631 0.224332905943372 no 2671 0.210875259946186 3853 595405 YLR310C CDC25 SGTC_2237 6667747 47.222 µM -0.804323237405669 0.224049103725608 no 2672 0.210605160401183 3817 729940 YDL015C TSC13 SGTC_1667 st014849 34.6 µM -0.804428975692757 0.224017030441958 no 2673 0.210574636254723 3884 5348460 SGTC_1408 3909-7976 48.8 µM -0.80663602157984 0.223348169404432 no 2674 0.209938107056521 3894 24152374 SGTC_2440 5628896 157.78 µM -0.806645891895863 0.223345180689352 no 2675 0.209935262922822 3856 5522048 SGTC_881 0833-0569 170 µM -0.807146406417367 0.22319365557516 no 2676 0.20979106924544 3853 5418700 SGTC_1196 1588-0294 184 µM -0.808106924306364 0.222903033615435 no 2677 0.209514515924499 3862 6144269 SGTC_2985 9022375 71.43 µM -0.808595312125222 0.222755345811485 no 2678 0.209373981074712 3855 4939335 SGTC_1235 benzylparaben 21.5 µM -0.809880565852969 0.222366953443827 no 2679 0.209004411190836 3850 7180 SGTC_1258 0671-0043 57.1 µM -0.81015893866592 0.222282882552064 no 2680 0.208924416782597 3881 4298767 SGTC_1937 st074714 47.2 µM -0.810413325913161 0.222206071360342 no 2681 0.208851330743915 3807 17250970 SGTC_2967 9089538 49.85 µM -0.810676487184969 0.222126626829413 no 2682 0.208775739762087 3904 728216 SGTC_2776 terbinafine 19.92 µM -0.81068713495744 0.222123412764244 no 2683 0.208772681613549 3860 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_2687 chenodiol 100 µM -0.811444078004827 0.221894995040444 no 2684 0.208555347521212 3890 5702181 A cholesterol synthesis inhibitor. SGTC_2434 5670830 169.91 µM -0.812017486482881 0.221722050671561 no 2685 0.20839079885501 3889 1549830 SGTC_2167 5876490 200 µM -0.812889594926993 0.221459163808758 no 2686 0.208140680342191 4011 686534 SGTC_2174 5790901 200 µM -0.813228775085504 0.221356970076558 no 2687 0.208043452194654 3896 786020 SGTC_791 1348-1292 225 µM -0.815486835447161 0.220677312553859 no 2688 0.207396848516037 3828 5437054 SGTC_590 k048-0076 22.4 µM -0.816525743256534 0.220365011816781 no 2689 0.207099753033651 3840 6832814 SGTC_1768 st044301 37.178 µM -0.816853106193255 0.220266657445238 no 2690 0.207006189556055 3858 3931349 SGTC_465 cgp-37157 41 µM -0.816871683009314 0.220261076899077 no 2691 0.207000880873299 3802 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange. SGTC_487 nimodipine 119 µM -0.816902726247836 0.220251751573146 no 2692 0.20699200985016 3735 4497 L-type voltage-gated calcium channels inhibitor SGTC_328 k915-0120 63.5 µM -0.817968497185954 0.219931733473035 no 2693 0.206687587921224 3850 6624543 SGTC_117 lucigenin 22.078 µM -0.819275435814995 0.219539664624009 no 2694 0.20631464206996 3894 65100 An acridine derivative; a dye stuff and potential carcinogen. SGTC_2765 myclobutanil 7.74 µM -0.819563609728312 0.21945326930969 no 2695 0.206232462933781 3886 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11 SGTC_921 1561-0023 372 µM -0.820415844982948 0.219197881218353 no 2696 0.2059895428564 3832 24050882 SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM -0.822102674775897 0.218692895484166 no 2697 0.205509231656785 3936 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_2989 9073649 71.4286 µM -0.822928527588025 0.218445904543618 no 2698 0.205274319401042 3786 21367202 SGTC_2452 5863136 48.41 µM -0.824067174506481 0.218105628666874 no 2699 0.204950695184599 3839 2184096 SGTC_2915 7971052 15.16 µM -0.826056079819082 0.217511993097288 no 2700 0.20438614022307 3715 5741558 SGTC_671 0560-0003 407 µM -0.827802222231323 0.21699158550716 no 2701 0.203891257993525 3784 3238678 SGTC_2704 st078022 71.1 µM -0.827817121284809 0.216987148199984 no 2702 0.203887038459392 3891 54697681 SGTC_334 1502-1024 68.5 µM -0.828156283457457 0.21688615148959 no 2703 0.203790999027691 3924 3296216 SGTC_1415 3966-0071 78.1 µM -0.828684553047446 0.216728895955686 no 2704 0.20364146439707 3806 2893185 SGTC_2088 5278280 127.392 µM -0.83008778492264 0.216311501591227 no 2705 0.203244576418917 3935 791502 SGTC_730 1436-0052 41.2 µM -0.83065900202933 0.216141725182222 no 2706 0.203083146544288 3891 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2 SGTC_2640 pentamidine 10.38 µM -0.831801730901633 0.215802316491709 no 2707 0.202760433371913 3888 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_1694 st024011 44.9 µM -0.833076296160498 0.21542411496376 no 2708 0.20240085055542 3897 2787533 SGTC_1614 st002383 48.6 µM -0.835486026208767 0.214710127842253 no 2709 0.201722055755701 3870 1947235 SGTC_352 k048-0007 5.11 µM -0.836716873468718 0.214345967132272 no 2710 0.201375866131746 3899 6811911 SGTC_1951 sophoraflavanone G 9.2 µM -0.836749887959868 0.214336204354299 no 2711 0.201366585341654 3871 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity. SGTC_2313 7726885 200 µM -0.838120642290509 0.213931084328454 no 2712 0.200981475342575 3918 726423 SGTC_1178 0988-0033 191 µM -0.838191206409969 0.213910241505311 no 2713 0.200961662495245 3949 5392207 SGTC_1396 3511-0007 98.6 µM -0.84064834077125 0.213185204975735 no 2714 0.200272484435019 3895 X1396 SGTC_3317 9138495 8.753 µM -0.841252986381813 0.213007009745901 no 2715 0.200103111165996 3842 17020139 SGTC_2172 5754775 163.918 µM -0.84146600509277 0.212944251666405 no 2716 0.200043460902111 3862 2263357 SGTC_1654 st012436 41.8 µM -0.841536269930531 0.212923553099208 no 2717 0.200023787434934 3831 4323132 SGTC_964 1287-0107 19.4 µM -0.841919456511698 0.21281069492444 no 2718 0.199916519411452 3920 51516812 YPR165W RHO1 SGTC_2617 dihydrotanshinone i 20.83 µM -0.841972961759232 0.212794939049652 no 2719 0.199901544076801 3897 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12 SGTC_2320 7373003 200 µM -0.844001688155404 0.212198035561686 no 2720 0.199334231129781 3973 5415828 SGTC_2393 9031399 185.94 µM -0.847115571647568 0.211283757621003 no 2721 0.198465353245627 3936 1526623 YDL150W RPC53 SGTC_1846 st056244 14.8 µM -0.847738723813196 0.211101069309992 no 2722 0.198291747688565 3934 5393182 SGTC_1917 st066507 28.5 µM -0.850005622980432 0.210437268331173 no 2723 0.197660980022853 3887 3156428 SGTC_1260 0700-1617 7.75 µM -0.850460671178025 0.210304167413984 no 2724 0.197534508571167 3927 2853078 SGTC_2402 5553605 200 µM -0.850648139250195 0.210249347663918 no 2725 0.19748241984081 3962 6758546 SGTC_705 1124-0212 310 µM -0.852261891302027 0.209777798541308 no 2726 0.197034376115379 3845 9554485 SGTC_1882 5615643 20 µM -0.852759870673416 0.209632411278713 no 2727 0.196896240942947 3824 2253075 SGTC_2742 clothiapine 36.27 µM -0.853104794380174 0.209531744035743 no 2728 0.196800596467497 3846 16351 An atypical antipsychotic. YIL048W NEO1 SGTC_2959 9079155 11 µM -0.853781402583414 0.209334356084158 no 2729 0.196613060382366 3957 16189457 SGTC_1492 4158-0558 28.5 µM -0.858562303165197 0.207942738196571 no 2730 0.195291021666671 3915 3967268 SGTC_502 l-744,832 89.3 µM -0.861317739661339 0.207143176882411 no 2731 0.194531533978846 3923 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.  SGTC_207 4185-0010 4.486 µM -0.864019789658148 0.206360875873213 no 2732 0.193788509706513 3973 3761753 SGTC_3323 9138564 53.9225 µM -0.864177966053922 0.206315134748216 no 2733 0.193745067178458 3943 43912313 YNL103W MET4 SGTC_1771 st048882 4.1505 µM -0.869932837263795 0.204655042581174 no 2734 0.192168554483487 3942 4580403 SGTC_2558 carylophyllene oxide 100 µM -0.870471554164618 0.204500048194012 no 2735 0.19202137898592 4016 6708694 An oxygenated terpenoid and antifungal agent. SGTC_2048 5246248 200 µM -0.870780301729584 0.20441124984786 no 2736 0.191937061378129 3921 677046 SGTC_2946 9065502 71.43 µM -0.870950660745335 0.20436226301741 no 2737 0.191890546780498 3778 16489101 SGTC_275 trichlorophene 5.69 µM -0.872939024282001 0.203791024955244 no 2738 0.19134815707379 3958 62616 SGTC_3327 9140648 26.9345 µM -0.876599375726809 0.202741932765897 no 2739 0.190352139198953 3962 8029710 SGTC_1525 8-methoxypsoralen 92.5 µM -0.878921084591679 0.202078184255881 no 2740 0.189722032809283 4001 4114 Related to psoralen; DNA damaging agent. SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM -0.879312945346178 0.201966284402073 no 2741 0.189615809384066 3967 6708784 An antioxidant flavonoid SGTC_1702 st027038 51 µM -0.881180714093155 0.201433433815605 no 2742 0.189110008031951 3975 5521182 SGTC_1320 1313-0481 95.3 µM -0.881520118851993 0.201336696507788 no 2743 0.189018184779388 3942 6813365 YLR208W SEC13 SGTC_839 0122-0028 230 µM -0.884808512751799 0.200400879652426 no 2744 0.188129958693758 3929 759448 SGTC_1528 arabinosylhypoxanthine 74.6 µM -0.886139482917875 0.200022853849699 no 2745 0.187771184661426 4037 804 An inhibitor of viral and cellular DNA polymerases. SGTC_1553 gossypol 38.6 µM -0.887190325965488 0.199724693602718 no 2746 0.187488219961658 3812 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_2982 9019404 25.97 µM -0.888467906170839 0.199362560611848 no 2747 0.1871445560132 3911 22333232 SGTC_1705 st027868 56.3335 µM -0.890730271850473 0.198722258668239 no 2748 0.186536945266062 3913 292948 SGTC_2466 5983409 37.09 µM -0.890750987351446 0.198716401436028 no 2749 0.186531387288515 3975 2879657 SGTC_1948 st076329 66.6 µM -0.890824791316615 0.198695534480644 no 2750 0.186511586487472 3825 24208413 SGTC_994 3910-0338 138 µM -0.891333005652973 0.198551880438984 no 2751 0.186375273455919 4048 3479481 SGTC_1039 k821-0043 94 µM -0.892337826232402 0.198268037995064 no 2752 0.186105942611108 3968 15992768 SGTC_1252 0493-0875 34.8 µM -0.892772286060577 0.198145387347691 no 2753 0.185989565289333 3944 3960963 SGTC_1271 0832-2808 169 µM -0.893100550549138 0.198052746677635 no 2754 0.185901664094883 4010 3663794 SGTC_2795 7780010 54.55 µM -0.893113953754324 0.198048964668053 no 2755 0.185898075592126 3967 953673 SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM -0.893545021535081 0.197927352656627 no 2756 0.185782686708525 3915 4330530 SGTC_1579 chlormadinone acetate 49.4 µM -0.896311667549486 0.197147906140589 no 2757 0.185043164678027 3998 45114258 A steroidal progestin. SGTC_2055 5235184 200 µM -0.897583253005616 0.196790286543389 no 2758 0.184703885306806 4034 2836034 SGTC_2363 9053361 176 µM -0.897881587252911 0.196706440206914 no 2759 0.184624340997977 4039 6469797 YMR079W SEC14 SGTC_3291 9121177 71.43 µM -0.90071779875841 0.195910408885305 no 2760 0.183869191381264 3992 17015612 SGTC_2584 androsterone 48.74 µM -0.901366125138129 0.195728719825723 no 2761 0.183696843086848 3944 2754130 A steroid. SGTC_2079 5212404 121 µM -0.903236581487876 0.195205110639004 no 2762 0.183200173350419 3920 758462 SGTC_224 benfluorex 43.875 µM -0.903368979964571 0.195168079747632 no 2763 0.183165048823891 3975 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis. SGTC_315 k915-0449 187 µM -0.903485659805679 0.195135448783778 no 2764 0.183134097839986 3998 20970215 YNL149C PGA2 SGTC_1229 0139-0193 12.2 µM -0.904001737205721 0.194991161114735 no 2765 0.182997240114956 4034 3090752 SGTC_1098 clofazimine 15.1 µM -0.905842163312208 0.194477133340073 no 2766 0.182509700291321 4042 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2 SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM -0.90624766611544 0.194363988103405 no 2767 0.182402389355955 4001 2374 Ca(2+)-ATPase inhibitor. SGTC_1687 st020778 55.3625 µM -0.906707405517501 0.194235758012344 no 2768 0.182280773115687 3984 4259299 SGTC_2353 9059630 146.67 µM -0.90734869898947 0.194056975108433 no 2769 0.182111214495863 4031 4779114 SGTC_742 0kpi-0133 140 µM -0.907847699496232 0.19391793070815 no 2770 0.181979346507944 4041 2728852 SGTC_475 α-linolenic acid 10 µM -0.909729486815549 0.193394124997504 no 2771 0.181482594763302 3993 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_3226 9131256 49.47 µM -0.914670278184039 0.192022943327756 no 2772 0.180182376041793 3906 17178073 SGTC_120 rhodamine 6G 52.259 µM -0.915895807597531 0.191683754219242 no 2773 0.179860772954762 4018 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase SGTC_2215 7188065 200 µM -0.916795536387859 0.191434970500571 no 2774 0.179624896035619 3999 940217 SGTC_2709 st078560 56 µM -0.916885924262742 0.191409988319783 no 2775 0.179601210296659 3967 17250903 SGTC_2739 tacrine 100.86 µM -0.917035168135645 0.191368743383267 no 2776 0.179562105902477 4043 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders. SGTC_694 1315-0438 43.2 µM -0.919053079067182 0.190811609691057 no 2777 0.179033904847785 3965 6793154 SGTC_2863 9028737 58.44 µM -0.919862353902851 0.190588453414206 no 2778 0.178822346931165 3969 6460917 SGTC_1291 0993-0025 5.79 µM -0.920112566027924 0.190519490248234 no 2779 0.178756969176261 3990 4353356 SGTC_2407 paclitaxel 400 µM -0.922159077591611 0.189956008487828 no 2780 0.178222802570754 4156 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_704 1310-0270 142 µM -0.922251897981281 0.189930475846598 no 2781 0.178198599093335 4012 5718033 SGTC_2451 5856223 45.7 µM -0.924200296095635 0.189395005781107 no 2782 0.177691020752869 3980 2179896 SGTC_108 0509-0257 621.132 µM -0.926806560993526 0.188680191315549 no 2783 0.177013488925158 3970 536624 SGTC_580 1123-0028 41 µM -0.928643698816803 0.188177324293599 no 2784 0.176536883666854 4063 1677248 YPR107C YTH1 SGTC_3277 9138724 49.47 µM -0.929581176250865 0.187921034087321 no 2785 0.17629398868215 3943 15943418 SGTC_480 am 92016 50 µM -0.930044999452386 0.187794312533562 no 2786 0.176173893006185 3972 2129 K+ channel blocker. SGTC_290 2043-6722 48.1 µM -0.93106111641154 0.18751688281715 no 2787 0.175910975398849 4024 773758 YLR208W SEC13 SGTC_1305 1181-0477 144 µM -0.931542496235018 0.187385540476429 no 2788 0.175786506416067 4057 6252086 SGTC_86 0417-1630 471.922 µM -0.931835571729698 0.187305603990679 no 2789 0.175710754065451 4025 3634867 SGTC_175 3793-3120 23.7 µM -0.932929166728006 0.187007511565281 no 2790 0.175428270964019 4021 5322297 SGTC_248 streptozotocin 5.23457 mM -0.936927917218115 0.185920031753014 no 2791 0.174397818873829 4021 5300 DNA alkylating agent. SGTC_1114 scopoletin 1.73284 µM -0.937522361594896 0.185758705146608 no 2792 0.174244963358225 4048 5280460 A coumarin with genotoxic properties. SGTC_3112 9123419 49.47 µM -0.938010399244368 0.185626321255647 no 2793 0.174119532945199 4050 17015854 SGTC_1211 1056-0033 32.3 µM -0.938032865009399 0.185620228657287 no 2794 0.174113760407621 4067 6741922 SGTC_699 0375-0592 111 µM -0.938035643246242 0.18561947522256 no 2795 0.174113046553156 4091 762578 SGTC_2667 digitoxin 100 µM -0.938916881741111 0.185380586439047 no 2796 0.173886710486834 3945 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_2396 5342950 42.78 µM -0.94235286804419 0.184450973085413 no 2797 0.173006004606224 4018 1886677 SGTC_2095 5432005 200 µM -0.946047839651328 0.183454532758725 no 2798 0.172062093117126 4036 783734 SGTC_1728 st035614 33.7865 µM -0.946852768829759 0.183237909662183 no 2799 0.171856904083146 4012 15945546 SGTC_2551 apiole 73.87 µM -0.947826945285926 0.182975952079341 no 2800 0.171608780357849 3881 10659 A possible DNA adduct former. SGTC_21 0849-0113 22.993 µM -0.947947522965847 0.182943544811099 no 2801 0.171578085026973 3975 1560156 SGTC_1268 0828-0275 2.46 µM -0.949165908252111 0.182616284366273 no 2802 0.171268118825365 4089 745337 SGTC_2087 5276107 200 µM -0.949759333066314 0.182457021885473 no 2803 0.171117276912262 3988 144405 SGTC_3157 9099274 49.47 µM -0.950647754041667 0.182218751006949 no 2804 0.170891609163687 4041 17217662 SGTC_381 3461-2219 42.7 µM -0.950968218686975 0.18213285144496 no 2805 0.170810254715471 4036 2883159 SGTC_1054 3429-0080 167 µM -0.951337365783939 0.182033934080335 no 2806 0.170716572267464 4082 1162877 SGTC_1739 st037196 92.5 µM -0.95150589597661 0.181988785576486 no 2807 0.17067381347587 4115 612214 SGTC_2415 st077333 57.7 µM -0.952453012099323 0.181735187561448 no 2808 0.170433642581418 4076 2766255 SGTC_1799 st045822 46.1415 µM -0.95465031589155 0.181147693633996 no 2809 0.169877281561827 4003 3674992 SGTC_449 xestospongin c 11.1929 µM -0.954661929040335 0.181144591785905 no 2810 0.16987434418989 4046 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1 SGTC_373 0844-0104 25.9 µM -0.954802163704218 0.181107138023064 no 2811 0.169838876504311 4060 5375804 SGTC_621 3584-0052 32.1 µM -0.95489595985959 0.181082089728004 no 2812 0.169815156542384 4036 2273927 SGTC_3185 9108267 49.47 µM -0.955412374759734 0.180944219827157 no 2813 0.169684599239024 4038 4910486 SGTC_3200 9114385 49.47 µM -0.955478944845634 0.180926452061921 no 2814 0.169667774025298 4093 17018030 YLR208W SEC13 SGTC_3261 9137475 49.47 µM -0.956323444768207 0.180701147302029 no 2815 0.169454424334219 3957 17027690 SGTC_540 1187-0821 17.3 µM -0.956410746504699 0.18067786604402 no 2816 0.169432378739196 3982 847520 SGTC_2925 9010536 32.5 µM -0.956599215562348 0.180627612325681 no 2817 0.169384792462246 3996 2994177 SGTC_687 k029-0044 34.9 µM -0.957291467030048 0.180443104420393 no 2818 0.169210080523348 4119 5829338 SGTC_3054 9094397 49.47 µM -0.959242714288895 0.179923669124039 no 2819 0.168718243399635 4052 2598354 SGTC_3087 9117406 49.47 µM -0.961724064128841 0.17926447480764 no 2820 0.16809411553551 4074 42546093 SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM -0.964070555880532 0.178642505981922 no 2821 0.167505276739413 4176 16725076 SGTC_1529 apigenin 74 µM -0.964609128909094 0.178499942009238 no 2822 0.167370312627917 4082 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_1241 0364-0022 50.8 µM -0.964812315145561 0.178446175842934 no 2823 0.167319413231893 4073 4563895 SGTC_287 k060-0039 29.6 µM -0.965041297458733 0.178385595871349 no 2824 0.167262063718343 4103 5861974 SGTC_1227 3909-8010 46.6 µM -0.965630179758608 0.17822985963304 no 2825 0.167114634047395 4037 15982272 SGTC_1292 0kpi-0043 232 µM -0.965828209021132 0.178177507930029 no 2826 0.167065075247636 4061 3333905 SGTC_1369 1866-0067 208 µM -0.966894777486407 0.177895712898271 no 2827 0.166798318835493 4062 3531355 SGTC_1410 3909-8106 77.9 µM -0.966962326465813 0.17787787544331 no 2828 0.166781433609972 4104 1039210 SGTC_2341 7987486 176.74 µM -0.967446175425369 0.177750139890854 no 2829 0.166660518077193 4089 1258686 SGTC_936 3005-4620 401 µM -0.969766780949693 0.177138307422197 no 2830 0.16608137727447 4101 777207 SGTC_2456 5770359 74.46 µM -0.972658629775241 0.176377729702614 no 2831 0.165361496436077 4085 3118787 SGTC_1854 st056233 32.9 µM -0.973892771411782 0.176053771253173 no 2832 0.165054891628979 3951 5393174 SGTC_2377 9073351 62.6 µM -0.975324698888746 0.175678367047395 no 2833 0.164699611323484 4032 7337946 YHR072W ERG7 SGTC_134 0269-0018 6.916 µM -0.975386401714916 0.175662202005764 no 2834 0.1646843131724 4029 4378915 SGTC_3133 9127736 49.47 µM -0.978917323238853 0.174738733825307 no 2835 0.163810415986072 4044 27243420 SGTC_2128 5255449 168.493 µM -0.979710369623577 0.174531747096841 no 2836 0.163614552998173 4053 736008 SGTC_2021 4019055 173 µM -0.980225492638755 0.174397382393254 no 2837 0.163487411753671 3939 44827708 YER133W GLC7 SGTC_1284 0929-0043 16 µM -0.980733632193115 0.174264903656828 no 2838 0.163362057030547 4037 1239883 SGTC_2187 6125751 200 µM -0.982035573357857 0.17392576220353 no 2839 0.163041161625748 4085 874498 SGTC_1381 2324-0066 62.1 µM -0.982056634900825 0.173920279353478 no 2840 0.163035973860788 4129 10885928 SGTC_1153 4055-0057 267 µM -0.98333793206565 0.173586932175741 no 2841 0.162720573523872 4116 882706 SGTC_3110 9122132 49.47 µM -0.98606306914449 0.172879302986458 no 2842 0.162051082385104 4178 918317 SGTC_1411 3909-8223 150 µM -0.987372031459491 0.172540062650554 no 2843 0.161730145116469 4100 X1411 SGTC_2210 7115885 190.385 µM -0.987376847493713 0.172538815275903 no 2844 0.161728965064902 4137 2927039 SGTC_2004 4023728 41.89 µM -0.987903813216855 0.172402363510018 no 2845 0.161599878882699 4069 360084 YDR527W RBA50 SGTC_2496 diffractaic acid 79.83 µM -0.987962432053139 0.172387189086235 no 2846 0.161585523691646 4107 94870 An apoptosis inducer which activates caspases. SGTC_1844 rapamycin 4 nM -0.988112176349748 0.17234842924709 no 2847 0.161548856523281 3984 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2 SGTC_26 0302-0163 425.158 µM -0.996037450605715 0.170304986401391 no 2848 0.159615974562043 4130 3100915 SGTC_903 1134-0042 114 µM -0.997082501886303 0.170036694617115 no 2849 0.159362232864981 4110 701009 SGTC_44 0929-0055 61.211 µM -0.998181850618275 0.169754755816371 no 2850 0.159095592791757 3999 1379590 SGTC_949 1165-0505 146 µM -0.998515603891108 0.16966922086505 no 2851 0.159014700916297 4098 6244267 SGTC_318 1488-0629 67.2 µM -1.00059871442709 0.16913598204906 no 2852 0.158510425936038 4135 3662576 SGTC_3343 9148379 18.9835 µM -1.00133395317253 0.168948031377451 no 2853 0.158332691600874 4128 1955036 SGTC_1344 1488-0097 29.1 µM -1.00176901897013 0.168836877774331 no 2854 0.158227581744363 4126 747966 SGTC_725 1497-0963 19 µM -1.00293413052653 0.16853943852273 no 2855 0.157946321818363 4197 3549977 SGTC_1763 st044482 94.5 µM -1.00420491151326 0.168215407447877 no 2856 0.157639927615923 4092 88505 SGTC_959 1222-0044 107 µM -1.00579910252935 0.167809478557947 no 2857 0.157256109556238 4098 6083612 SGTC_110 0850-0284 111.64 µM -1.00691763850258 0.167525042539601 no 2858 0.156987177484861 3898 3906265 SGTC_940 3232-1287 54.8 µM -1.00891621264944 0.167017592604899 no 2859 0.15650740956642 4029 1585493 YIL048W NEO1 SGTC_1836 st055642 81 µM -1.01027495666348 0.166673166006 no 2860 0.156181787996396 4108 8571 SGTC_3164 9100705 49.47 µM -1.0138651842487 0.165765290363405 no 2861 0.155323543139506 4129 17174235 SGTC_136 0097-0015 404.482 µM -1.01428207259858 0.165660077648777 no 2862 0.155224087944139 4093 4861337 SGTC_1147 3809-1045 12.3 µM -1.014930623555 0.165496484659347 no 2863 0.155069449616079 4081 325925 SGTC_2147 5545932 89.7195 µM -1.01519340609692 0.165430229138553 no 2864 0.15500682159035 4128 797404 SGTC_2777 climbazole 1.536 µM -1.01688892333766 0.165003149970984 no 2865 0.154603136628438 3969 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2 SGTC_2550 chrysin dimethyl ether 71.87 µM -1.01815713341683 0.16468417113892 no 2866 0.15430164365475 3935 88881 An O-methylated flavonoid and antioxidant. SGTC_2716 st080858 38.6235 µM -1.01844482193173 0.164611867665133 no 2867 0.154233305286073 4074 5296050 SGTC_310 1273-0058 1.06 µM -1.01856440826486 0.164581818617745 no 2868 0.154204904290361 3972 2734232 SGTC_2861 9024595 19.48 µM -1.01890822794288 0.164495445155279 no 2869 0.15412326856702 4000 16482810 SGTC_1574 spiramycin 23.7 µM -1.01904984258626 0.164459877646591 no 2870 0.154089652238416 4077 6419898 An antibiotic and protein synthesis inhibitor. SGTC_1416 3966-0321 25.3 µM -1.02044983465367 0.164108528098432 no 2871 0.153757584674886 4140 582530 YLR208W SEC13 SGTC_1588 farnesol 29.9 µM -1.02163641593012 0.16381111876925 no 2872 0.153476507714567 4109 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_2953 9074162 66.49 µM -1.02166726426892 0.163803391490413 no 2873 0.153469204912445 4113 16451992 SGTC_3041 9091929 49.47 µM -1.02181166981414 0.163767222124066 no 2874 0.153435022497631 4117 25236887 SGTC_2787 5284540 71.43 µM -1.02371810940301 0.163290200786401 no 2875 0.152984219624329 4166 736958 SGTC_2186 6124449 200 µM -1.02606261137472 0.162704808305491 no 2876 0.152431036202012 4119 3834182 YLR033W RSC58 SGTC_600 1495-0418 41.6 µM -1.02874313455534 0.162037190241918 no 2877 0.151800197363878 4103 5377768 SGTC_1379 2144-0755 36.5 µM -1.03121753142228 0.161422496501158 no 2878 0.151219410588067 4181 5392327 SGTC_2067 5224629 34.075 µM -1.03424001633115 0.160673711749327 no 2879 0.150511985514046 4142 2835000 SGTC_2026 5148700 152 µM -1.03526929587295 0.16041923856062 no 2880 0.150271582381471 4101 79838 SGTC_863 0466-0191 129 µM -1.03559360749449 0.160339112199772 no 2881 0.150195887755258 4170 765160 YPR165W RHO1 SGTC_820 1582-0060 59.9 µM -1.03565087667718 0.160324965651927 no 2882 0.150182523716725 4143 3848840 SGTC_1146 3579-1023 7 µM -1.03671945235233 0.160061157294649 no 2883 0.149933311821681 4161 X1146 SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM -1.03782398560695 0.159788770277193 no 2884 0.149676003955237 4047 5355888 SGTC_564 3555-0129 330 µM -1.03817847026523 0.159701415753038 no 2885 0.149593487043707 3965 563260 SGTC_366 0181-0206 4.31 µM -1.04015436797149 0.159215074210646 no 2886 0.149134093992031 4155 274874 SGTC_1403 3909-7815 62.9 µM -1.04053720626288 0.159120955840391 no 2887 0.149045193784829 4084 6615483 SGTC_1955 wogonin 32.4 µM -1.04254766221593 0.158627296353791 no 2888 0.148578920002397 4197 5281703 A flavanone. SGTC_2647 atorvastatin 60.16 µM -1.04414962226088 0.158234661094631 no 2889 0.148208085281086 4107 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7 SGTC_2348 9022543 33.42 µM -1.04502334459729 0.158020783559839 no 2890 0.14800609014036 4180 3162678 YDL140C RPO21 SGTC_2698 st077697 67.5 µM -1.04591647213821 0.157802352091258 no 2891 0.147799799262989 4114 3154499 SGTC_3259 9138485 49.47 µM -1.04758230545013 0.157395470731231 no 2892 0.147415546681273 4139 17646153 SGTC_581 0958-0271 211 µM -1.04774824327761 0.157354978060435 no 2893 0.147377307013956 4136 4591145 SGTC_933 2914-0560 114 µM -1.04796491101444 0.157302116426648 no 2894 0.147327386861538 4188 463887 SGTC_1760 st045453 10.4495 µM -1.048124005873 0.157263308602818 no 2895 0.147290738691641 4195 3323419 YIL048W NEO1 SGTC_293 4049-0273 38.5 µM -1.04967618484949 0.156885017708672 no 2896 0.146933508350919 4013 1380311 SGTC_2867 9039098 71.43 µM -1.04988036027288 0.156835301480293 no 2897 0.146886561139973 4088 6463460 SGTC_288 1315-0019 35.1 µM -1.05172263514976 0.156387180774168 no 2898 0.146463411438418 4203 6811474 SGTC_511 blebbistatin 171 µM -1.05238457116059 0.156226375516952 no 2899 0.146311572253371 4203 3476986 A myosin inhibitor. SGTC_2891 9063876 19.48 µM -1.05311887168735 0.156048118113293 no 2900 0.146143257331843 4139 6472478 SGTC_7 0192-1582 4.227 µM -1.05374435938725 0.155896381666794 no 2901 0.145999986889473 4188 252616 SGTC_1048 3161-0300 24.5 µM -1.05556359818279 0.155455607343404 no 2902 0.145583819556057 4136 2165101 SGTC_2041 5107442 45.335 µM -1.06321156316158 0.153611622228449 no 2903 0.143843009875888 4202 793005 SGTC_852 0418-0143 439 µM -1.06386516837333 0.153454707365653 no 2904 0.143694892052823 4171 5369229 SGTC_2563 tomatine 8.54 µM -1.0644835380536 0.153306349476375 no 2905 0.1435548539696 4106 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties. SGTC_1788 fluconazole 20 µM -1.06490743047941 0.153204705057893 no 2906 0.14345891109664 4200 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11 SGTC_2636 apigenin dimethyl ether 100 µM -1.06955593785124 0.152092978298489 no 2907 0.14240961869809 4155 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_2278 7948257 134.34 µM -1.07062180787293 0.151838824121017 no 2908 0.142169756869783 4155 1247028 SGTC_1158 4092-0494 91.8 µM -1.07095678285361 0.151759008442071 no 2909 0.1420944310887 4265 1148199 SGTC_1120 ficusin 1.78878 µM -1.07453781658377 0.150907485230164 no 2910 0.141290852529223 4214 6199 A DNA cross-linker. SGTC_3100 9120536 49.47 µM -1.07561998181254 0.150650787374699 no 2911 0.141048623589904 4008 16421196 SGTC_741 4582-0002 126 µM -1.07632265131492 0.15048426459881 no 2912 0.140891490839879 4155 2912688 SGTC_2122 5258151 111.688 µM -1.07642307896936 0.150460474677742 no 2913 0.140869042653939 4162 2173356 SGTC_217 ketoconazole 989 nM -1.07944944001074 0.149744746994795 no 2914 0.140193710642228 4015 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4 SGTC_3262 9137218 49.47 µM -1.07988056846239 0.149642971202006 no 2915 0.140097683653478 4069 17650664 SGTC_772 k072-0172 35.3 µM -1.08139512789552 0.149285797565133 no 2916 0.139760693983901 4214 5861980 SGTC_1959 st077091 55.8 µM -1.08159650652134 0.149238350006302 no 2917 0.139715928754331 4168 821356 YKL052C ASK1 SGTC_2292 7671323 168.05 µM -1.0825245723693 0.149019815148966 no 2918 0.139509751417979 4250 937504 SGTC_1576 erythromycin ethylsuccinate 23.2 µM -1.08318258155453 0.148865001043249 no 2919 0.13936369478759 4166 3256 An antibiotic and ribosome inhibitor. SGTC_2400 5203494 178.7 µM -1.08365937869232 0.148752889051999 no 2920 0.139257926358708 4086 6777674 SGTC_973 1325-0077 65.9 µM -1.08388116053976 0.148700759474164 no 2921 0.139208746867166 4179 2835149 SGTC_2032 5185112 25.99 µM -1.08592725698404 0.148220402812843 no 2922 0.138755588341771 4059 5718189 SGTC_2060 5238662 140 µM -1.08600957176616 0.148201099736458 no 2923 0.138737378750057 4172 790130 SGTC_1162 k048-0130 20.1 µM -1.0861316942775 0.14817246472075 no 2924 0.138710365932191 4131 6797406 SGTC_3270 9137563 49.47 µM -1.08666311803842 0.148047900763727 no 2925 0.138592859678744 4164 17015724 SGTC_462 ag-879 158 µM -1.08764648459614 0.14781758780256 no 2926 0.138375600580867 4203 6809654 Ag-879 is a 5-Lipoxygenase inhibitor. SGTC_984 1492-0255 2.91 µM -1.08770173767136 0.147804654176206 no 2927 0.138363400190121 4152 1585198 SGTC_436 n,n-dimethylsphingosine 3.3 µM -1.09037770430331 0.147179171523413 no 2928 0.137773399493775 4286 5282309 SGTC_1407 3909-7909 12.3 µM -1.09080404225524 0.147079683052878 no 2929 0.137679558707056 4180 4411780 SGTC_1719 st032227 49.2 µM -1.09153512426841 0.146909185743526 no 2930 0.137518742589079 4190 3125804 SGTC_210 3551-0445 56.827 µM -1.09207047253933 0.146784420058574 no 2931 0.137401063386207 4230 2865180 YOR207C RET1 SGTC_2352 9027995 87.8 µM -1.09339089627206 0.146476992446052 no 2932 0.13711110445968 4147 2997347 SGTC_2201 6605497 169.863 µM -1.09341158294589 0.146472179513196 no 2933 0.137106565090533 4114 670741 SGTC_2243 6634756 200 µM -1.09542612706425 0.146003986991478 no 2934 0.136664996489398 4252 885676 SGTC_3082 9117008 49.47 µM -1.09799368682138 0.145408729137916 no 2935 0.136103623006755 4236 41448529 SGTC_3271 9137798 49.47 µM -1.09816514714168 0.145369036352601 no 2936 0.136066191074814 4133 6498326 SGTC_1509 1326-1131 80 µM -1.09911168026555 0.145150046660313 no 2937 0.135859677890134 4154 768313 SGTC_2783 7738165 71.43 µM -1.09959662222908 0.145037936648041 no 2938 0.135753957168578 4189 17201110 SGTC_3223 9129970 49.47 µM -1.10088908301184 0.144739427293666 no 2939 0.135472466984239 4214 17248386 SGTC_2329 6138490 200 µM -1.10109114882624 0.144692795193685 no 2940 0.135428494446021 4296 720019 SGTC_1076 itraconazole 331 nM -1.10126852536638 0.144651869146275 no 2941 0.135389902725135 4192 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1 SGTC_1409 3909-8004 61.9 µM -1.10169937960231 0.14455249072604 no 2942 0.135296193386188 4217 2119279 SGTC_3165 9101544 49.47 µM -1.1026816261792 0.144326103245182 no 2943 0.135082724327803 4202 5002184 SGTC_1273 0849-0096 14.1 µM -1.10286382698321 0.144284136025191 no 2944 0.135043152516798 4219 5286025 SGTC_1383 3049-0032 20.7 µM -1.10339653276518 0.144161482432155 no 2945 0.134927500868571 4261 712864 SGTC_1921 5740136 50 µM -1.10517640278121 0.143752183699562 no 2946 0.134541579820362 4161 1774243 SGTC_2981 9013952 38.96 µM -1.10559487822329 0.143656065089574 no 2947 0.134450953836576 4174 2996344 SGTC_3089 9117425 49.47 µM -1.10579595939457 0.143609894673944 no 2948 0.13440742215647 4201 9401657 SGTC_542 3381-0244 89.3 µM -1.10753102591164 0.143211920665407 no 2949 0.134032202921395 4219 1112843 SGTC_1725 st036284 20.55 µM -1.10880965761912 0.142919116771648 no 2950 0.133756151671704 4267 707914 SGTC_910 3454-3003 490 µM -1.10934538457899 0.142796556806829 no 2951 0.133640606722633 4135 820824 SGTC_1567 st069303 68.4 µM -1.11104895411434 0.142407298032774 no 2952 0.133273639081497 4251 5581319 SGTC_2488 5268135 45.7 µM -1.11414467096843 0.141701778042198 no 2953 0.132608563624578 4270 1270356 YLR208W SEC13 SGTC_2130 NSC 7 2.4545 µM -1.11458015330493 0.141602721036635 no 2954 0.132515189533222 4279 21448 SGTC_1186 1319-0216 26 µM -1.11503835877159 0.141498545973329 no 2955 0.13241699217324 4277 4565136 SGTC_3186 9110464 49.47 µM -1.1204180462951 0.140279334114425 no 2956 0.131267829127123 4218 17018021 SGTC_2518 prenyletin 46.28 µM -1.12085730495767 0.140180099859691 no 2957 0.131174303497066 4185 3873459 A coumarin with calcium channel inhibitory activity. SGTC_450 aminopyrene 156 nM -1.12143992810592 0.140048551286096 no 2958 0.131050324157335 4161 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1 SGTC_1691 st019933 84.6 µM -1.12277661645708 0.139747061850664 no 2959 0.130766189448372 4208 6176082 SGTC_1609 st001574 46.4 µM -1.122795656437 0.139742770581757 no 2960 0.130762145271296 4192 3960012 SGTC_3086 9117350 49.47 µM -1.12748922003479 0.138687658127749 no 2961 0.129767847868773 4154 2679265 SGTC_2505 galangin 7.89 µM -1.1294150607823 0.138256303561277 no 2962 0.129361391212863 4115 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_380 3970-0968 6 µM -1.12956286482737 0.138223235879088 no 2963 0.129330233052364 4102 2891601 SGTC_2970 9090938 41.86 µM -1.12971119392658 0.138190056149712 no 2964 0.129298969435955 4299 17217104 SGTC_1558 st069300 45.6 µM -1.13285125145487 0.137488930995694 no 2965 0.128638362257685 4156 24208000 SGTC_2789 5281112 71.43 µM -1.13328520651829 0.137392227040777 no 2966 0.128547251065615 4244 765948 SGTC_2531 methyl deoxycholate 70.07 µM -1.13381428209268 0.13727438896661 no 2967 0.128436229413865 4171 16667744 Haematoxylin. SGTC_1871 st057448 67.3 µM -1.13389295401034 0.137256872702742 no 2968 0.128419726520561 4272 691747 SGTC_159 3970-0959 50 µM -1.1341111049936 0.137208309479054 no 2969 0.128373973007695 4298 6615653 SGTC_1128 3448-9350 235 µM -1.13422061894192 0.137183934686441 no 2970 0.128351008559514 4267 619386 SGTC_1968 st069590 43.6 µM -1.13571028360507 0.13685267006245 no 2971 0.128038917650327 4205 6384066 SGTC_2263 7948595 193.29 µM -1.1359717989794 0.136794571968046 no 2972 0.127984183539864 4228 2971371 SGTC_652 0437-0092 114 µM -1.13598929286029 0.136790686139989 no 2973 0.127980522721488 4169 3091274 SGTC_2269 7935389 174.42 µM -1.13840625561804 0.136254543597498 no 2974 0.127475441565432 4204 97605 SGTC_395 anisomycin 6.25 µM -1.13893807719207 0.136136765594041 no 2975 0.12736449126414 4256 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_2886 9058944 51.95 µM -1.14079994751123 0.135724982084018 no 2976 0.12697659123996 4094 4949929 SGTC_938 3126-1755 342 µM -1.1409980725523 0.135681213719524 no 2977 0.126935362542932 4224 1777771 SGTC_2673 kobusone 100 µM -1.14105215595573 0.135669267681566 no 2978 0.126924109712689 4329 6710676 An epoxy ketone and protein crosslinker. SGTC_1729 st035615 45.989 µM -1.14372511066676 0.135079758325667 no 2979 0.126368828077561 4269 17385451 SGTC_1150 3909-7983 10.9 µM -1.14562265444205 0.13466233037267 no 2980 0.125975659707122 4207 23965914 SGTC_2678 equilin 100 µM -1.14689085547091 0.134383841367854 no 2981 0.125713366267331 4229 3247 Equilin is an estrone commonly used hormone replacement therapy SGTC_167 3672-0051 66.205 µM -1.15194609968939 0.133277672901426 no 2982 0.12467161151411 4154 3237971 SGTC_2366 9070441 60.58 µM -1.16083205814581 0.13134850223013 no 2983 0.122855101555985 4222 6837235 SGTC_1395 3486-0190 4.35 µM -1.16097772888441 0.131317038103398 no 2984 0.122825478284803 4241 6748079 SGTC_72 0744-0168 198.391 µM -1.1610475557693 0.131301957702615 no 2985 0.122811280223959 4138 677577 SGTC_939 1165-0479 45.3 µM -1.16229726146978 0.131032262980289 no 2986 0.122557369313307 4247 1377347 SGTC_761 k216-0224 480 µM -1.16233868840155 0.131023329334063 no 2987 0.122548958643419 4295 1340404 SGTC_2737 bleomycin 30.5 nM -1.16416022522859 0.130630934063622 no 2988 0.122179542894572 4327 16211318 Bleomycin acts by induction of DNA strand breaks. SGTC_2184 6075246 200 µM -1.16701038320752 0.13001858499767 no 2989 0.121603088205297 4252 2267320 SGTC_1805 st050013 60.3 µM -1.16762545927459 0.129886698571932 no 2990 0.12147893803864 4205 4037144 SGTC_2014 4013930 200 µM -1.16983141383625 0.129414453205685 no 2991 0.121034409585809 4227 64556 SGTC_1709 st033179 39.1045 µM -1.17302597245491 0.128732681137196 no 2992 0.120392695251032 4253 573381 SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM -1.17380770477999 0.128566226619842 no 2993 0.120236028597143 4339 4213774 SGTC_3021 9087658 49.47 µM -1.1779016213415 0.12769694737946 no 2994 0.119417914324037 4260 25237042 SGTC_2986 9022445 71.43 µM -1.17838018824699 0.127595598513598 no 2995 0.119322536175692 4265 6459286 SGTC_2248 tofa 1.1 µM -1.1785849644556 0.127552248966972 no 2996 0.119281740805732 4253 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_2808 7946468 45.46 µM -1.17884781603274 0.127496620321529 no 2997 0.119229390130743 4251 2970879 SGTC_114 0364-0001 490.298 µM -1.17978165338182 0.127299123913994 no 2998 0.119043534138635 4298 4003655 SGTC_649 1123-0311 367 µM -1.18139653495575 0.126958096494988 no 2999 0.118722616950462 4172 693629 YIL048W NEO1 SGTC_1997 st073024 93.8 µM -1.18871305186182 0.125420978832872 no 3000 0.117276301405357 4293 686268 SGTC_2036 5160441 105 µM -1.18994330095047 0.125163798531941 no 3001 0.117034338924514 4256 134534 YIL048W NEO1 SGTC_206 4546-0025 72.014 µM -1.19013398545037 0.125123969431204 no 3002 0.116996867234663 4328 6620745 YIL048W NEO1 SGTC_563 tetrahydrosecaminediol 614 µM -1.19084606689459 0.124975312130777 no 3003 0.116857010228341 4320 334274 A psychoactive constituent of the cannabis plant. SGTC_2515 chrysin 20.77 µM -1.19093751998042 0.124956228920325 no 3004 0.116839056892243 4291 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor. SGTC_1523 st012844 44.7 µM -1.19160814652273 0.12481635370956 no 3005 0.116707464605444 4360 4274103 SGTC_1213 1315-0166 115 µM -1.19295156640307 0.124536480549389 no 3006 0.116444171031155 4310 768401 SGTC_1151 3909-8316 15.3 µM -1.1939188288728 0.124335243696306 no 3007 0.116254860709276 4322 800431 SGTC_2668 2',4'-dihydroxychalcone 15.08 µM -1.19419239738124 0.124278369641515 no 3008 0.116201358168555 4335 5357218 A potent inhibitor of glutathione S-transferases. SGTC_2477 5967686 25.23 µM -1.19493226322428 0.124124644960456 no 3009 0.116056748123872 4257 776118 SGTC_3293 9120939 62.045 µM -1.19650710149175 0.123797878030177 no 3010 0.115749364489605 4279 934087 SGTC_492 tmb-8 126 µM -1.19808381964266 0.123471324798553 no 3011 0.115442193627181 4253 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1 SGTC_3347 9188721 44.724 µM -1.19842335190983 0.123401083482684 no 3012 0.115376122977008 4301 44118411 YKL104C | YBL026W GFA1 | LSM2 SGTC_1334 1486-0610 236 µM -1.20256179086542 0.122547186402442 no 3013 0.114572970559128 4348 3742339 SGTC_985 1493-0307 8.71 µM -1.20343398696223 0.122367753655112 no 3014 0.114404211198114 4311 3278274 SGTC_2034 5197015 53.07 µM -1.20350160922743 0.122353849755017 no 3015 0.114391134506333 4296 780676 SGTC_3093 9117344 49.47 µM -1.20481831356809 0.122083341471719 no 3016 0.114136724268182 4306 24824913 SGTC_829 1635-0120 117 µM -1.20641661780849 0.121755544982938 no 3017 0.113828445866975 4297 285054 SGTC_382 3229-0966 23.2 µM -1.20829151212361 0.121371811394065 no 3018 0.113467576082193 4326 5722370 SGTC_2080 5212524 12.4 µM -1.20883252001714 0.121261241863197 no 3019 0.113363597569567 4239 260183 SGTC_1188 1403-0014 4.57 µM -1.20955132855898 0.121114443594084 no 3020 0.113225551984087 4280 9614867 SGTC_3265 9137266 49.47 µM -1.21049862899912 0.12092117269297 no 3021 0.113043808265147 4254 17224265 SGTC_3351 9150312 21.596 µM -1.21388425955942 0.120232201101282 no 3022 0.112395962215171 4201 4904905 SGTC_2426 5582046 32.21 µM -1.21540807404592 0.11992301101148 no 3023 0.112105245048602 4307 2251934 SGTC_234 nsc-17383 10.7 µM -1.21725390397853 0.119549233516265 no 3024 0.11175381338428 4322 408974 SGTC_3059 1327-0034 3 µM -1.21966255201493 0.119062723232438 no 3025 0.111296411571141 4158 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_1941 st076221 61.8 µM -1.22327420936195 0.118335845602274 no 3026 0.110613072434175 4183 2828568 SGTC_3017 9080681 49.47 µM -1.22631093300674 0.117727110743628 no 3027 0.110040844325925 4328 16451914 SGTC_518 1021-0119 62.6 µM -1.22700046103525 0.11758919877691 no 3028 0.109911208818405 4279 1097762 SGTC_1738 st035555 74 µM -1.22740361571832 0.117508617123373 no 3029 0.109835464050912 4346 5331140 SGTC_2212 7123476 200 µM -1.23014355462755 0.116961999977072 no 3030 0.109321676287924 4300 1085715 SGTC_536 3852-0578 10.6 µM -1.23072398601396 0.11684643573267 no 3031 0.109213056951961 4355 2869208 SGTC_1506 4226-2149 212 µM -1.23402809051842 0.116190128187369 no 3032 0.108596218527524 4328 991114 SGTC_768 0384-0033 77.3 µM -1.23544235171404 0.115910008836036 no 3033 0.108332959477661 4267 3965305 YMR134W ERG29 SGTC_559 1550-0661 158 µM -1.23683971223913 0.115633708232263 no 3034 0.108073297790321 4373 5830875 SGTC_1491 4138-0063 26.5 µM -1.24005937789863 0.114998864375152 no 3035 0.107476716291727 4309 23883227 SGTC_3189 9110682 49.47 µM -1.24385648220889 0.114253353175965 no 3036 0.106776194079571 4362 17122418 SGTC_1472 k841-0093 193 µM -1.24734248761949 0.113571958177539 no 3037 0.106135972403131 4446 X1472 SGTC_1009 4106-0057 9.87 µM -1.25408701672936 0.11226186944637 no 3038 0.104905189449338 4331 2928005 SGTC_1582 3',3',6'-trihydroxyflavone 74 µM -1.25655658250035 0.111784881189815 no 3039 0.104457122430979 4317 688803 SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM -1.25857235776334 0.111396616902033 no 3040 0.104092418267743 4308 16623 A steroid. SGTC_3090 9117696 49.47 µM -1.26120312402689 0.110891350604488 no 3041 0.103617836696089 4289 7923821 SGTC_2980 9014342 25.29 µM -1.26881855128901 0.109437988381608 no 3042 0.102252893517582 4389 2996599 SGTC_2755 lomerizine 42.69 µM -1.26946959355988 0.109314378319952 no 3043 0.102136814318179 4294 3949 A calcium channel blocker. SGTC_1346 1488-2224 62.4 µM -1.27092396863948 0.109038605941199 no 3044 0.101877849250628 4356 3722427 SGTC_3242 9133940 49.47 µM -1.27274224609107 0.108694535761578 no 3045 0.101554760614091 4343 17248444 SGTC_237 nikkomycin 200 µM -1.27899242996628 0.107517778376948 no 3046 0.100449860827545 4357 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine. SGTC_286 k060-0067 22.9 µM -1.27902852114546 0.107511010053389 no 3047 0.100443506245974 4380 5985051 SGTC_609 0986-0026 86.3 µM -1.2802048679006 0.107290573109908 no 3048 0.100236547183909 4315 2848610 SGTC_1765 st044815 90.4 µM -1.28277602699039 0.106809895598559 no 3049 0.0997852776287851 4381 645695 SGTC_1638 st008370 60.6 µM -1.29113853910976 0.105257275994575 no 3050 0.0983278212215692 4296 24207134 SGTC_2879 9041815 71.43 µM -1.29159394232684 0.105173195214 no 3051 0.0982489014878854 4385 4942971 SGTC_2435 5706476 10.6 µM -1.29646411126235 0.10427705706499 no 3052 0.0974078183788344 4354 5725375 SGTC_440 fluspirilene 35.1 µM -1.29678234431936 0.104218693630264 no 3053 0.097353043615199 4408 3396 An atypical antipsychotic. SGTC_1795 st049545 62.3 µM -1.30932990819168 0.101936329049498 no 3054 0.0952113114079638 4317 5291882 SGTC_1900 st060200 72.8 µM -1.31051748441816 0.10172221166189 no 3055 0.095010416648061 4364 688945 SGTC_2389 9091542 195.52 µM -1.31339487383272 0.101204782850453 no 3056 0.0945249619777252 4343 3626624 YOL127W RPL25 SGTC_1971 st069429 63.5 µM -1.31594341675382 0.100748093086822 no 3057 0.094096517457844 4370 1246522 YGL099W LSG1 SGTC_584 0986-0246 15.4 µM -1.31641897935273 0.100663040623633 no 3058 0.0940167278297253 4460 53315 YDR232W HEM1 SGTC_3033 9090887 49.47 µM -1.31661518631319 0.100627965061097 no 3059 0.09398382288717 4388 19325384 SGTC_545 4218-0007 221 µM -1.3193597361557 0.100138261088556 no 3060 0.0935244379173026 4369 2840508 SGTC_2252 omeprazole 400 µM -1.32009677215341 0.100007050219251 no 3061 0.0934013551682445 4401 4594 A proton pump inhibitor. SGTC_2062 5245942 200 µM -1.32287311456698 0.0995139189005873 no 3062 0.0929387887560506 4425 1376160 SGTC_2935 9038016 29.96 µM -1.32496674413 0.099143227470575 no 3063 0.0925910908257705 4345 6463195 SGTC_1560 lithocholic acid 53.1 µM -1.32631815616637 0.0989044876343122 no 3064 0.0923671676899572 4317 9903 A bile acid which acts as a detergent. SGTC_1340 1486-1359 257 µM -1.32740405792601 0.098712957707931 no 3065 0.0921875290385243 4325 4309068 SGTC_2204 7233102 200 µM -1.32930844667554 0.0983777198419936 no 3066 0.0918731143478612 4326 2172480 SGTC_3173 9105693 49.47 µM -1.33422487398144 0.0975161156792636 no 3067 0.0910650849708847 4368 17096658 SGTC_1338 1486-1223 76 µM -1.33543222426811 0.0973053764412563 no 3068 0.0908674619505609 4413 3444526 SGTC_886 0866-0150 153 µM -1.34374266789164 0.0958638734251802 no 3069 0.0895158073365834 4439 271463 SGTC_846 0335-0850 148 µM -1.3447735202142 0.0956861658569172 no 3070 0.0893491919923918 4390 6819598 SGTC_798 1287-0182 476 µM -1.3472485706838 0.0952604842643485 no 3071 0.0889500948414566 4434 1649755 SGTC_50 0929-0078 56.389 µM -1.34897372486237 0.0949646023726476 no 3072 0.0886727029050096 4243 1377751 SGTC_3010 9080089 71.4286 µM -1.35015508423462 0.0947623778533868 no 3073 0.0884831211154975 4404 17027233 SGTC_2933 9026794 32.47 µM -1.35044893512052 0.0947121259244806 no 3074 0.088436011545787 4336 17586027 SGTC_1630 st005209 31.3 µM -1.35047851612595 0.0947070683157879 no 3075 0.0884312702153625 4394 3367314 SGTC_2422 chlorphenesin carbamate 384.24 µM -1.35167646883646 0.094502415721329 no 3076 0.0882394179499243 4370 2724 A muscle relaxant with antifungal properties. SGTC_485 niflumic acid 177 µM -1.35181029319251 0.0944795740606253 no 3077 0.0882180052425625 4435 4488 A COX2 inhibitor. SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM -1.35297272112987 0.094281337568272 no 3078 0.0880321726431479 4381 6312947 SGTC_3125 9127534 49.47 µM -1.35795416681508 0.0934352924976575 no 3079 0.0872391139883061 4309 1639235 SGTC_668 1682-0499 62.6 µM -1.35989450113887 0.0931072695717394 no 3080 0.0869316556798076 4406 682214 SGTC_1620 st003704 16.5 µM -1.36064742239346 0.0929802140508339 no 3081 0.0868125687666828 4395 2834414 SGTC_466 geldanamycin 89.2 µM -1.3621249300944 0.0927312571307321 no 3082 0.0865792309302018 4420 5288382 HSP90 inhibitor. SGTC_3050 9093513 49.47 µM -1.36235089328271 0.0926932263145377 no 3083 0.0865435866921968 4370 25236664 SGTC_2692 st077426 47.7 µM -1.37408325490433 0.0907344219810812 no 3084 0.084707918667694 4411 25238571 SGTC_3012 9080433 71.4286 µM -1.38338572855523 0.0892032706205249 no 3085 0.0832733120687263 4416 17688859 SGTC_3336 9143619 71.43 µM -1.3833917879065 0.0892022795795675 no 3086 0.0832723835994778 4430 45595730 SGTC_3153 9100258 49.47 µM -1.3876921235798 0.0885009998911892 no 3087 0.082615407734835 4350 25236848 SGTC_3075 9116269 49.47 µM -1.38870357067968 0.0883366558312586 no 3088 0.0824614539850113 4432 17015205 YNL244C SUI1 SGTC_2523 spermine 47.74 µM -1.38923370993409 0.0882506075320525 no 3089 0.0823808470851555 4445 1103 A DNA binding polyamine. SGTC_371 0195-0006 7.36 µM -1.39492136556472 0.0873313564942819 no 3090 0.081519776723526 4278 3928593 SGTC_620 0109-0052 432 µM -1.39802807140624 0.0868322722917902 no 3091 0.0810523188390102 4480 493037 SGTC_452 diindolylmethane 8 µM -1.40345853857796 0.0859650049988446 no 3092 0.0802400736997478 4434 3071 Inhibits expression of several cancer promoting factors. SGTC_2643 anethole 100 µM -1.40574114892973 0.0856024040873997 no 3093 0.0799005016065134 4435 637563 An anti-fungal, anti-helmenthic and channel blocker. SGTC_477 mead ethanolamide 10 µM -1.4094301306474 0.0850188187940288 no 3094 0.0793540099183838 4419 16061185 SGTC_1436 4092-1007 8.32 µM -1.41085260215701 0.0847945866671425 no 3095 0.0791440401939574 4436 2881121 SGTC_506 n9-isopropylolomoucine 153 µM -1.41760248779386 0.0837366060185828 no 3096 0.0781534267101826 4439 6610355 SGTC_925 2064-1272 59.6 µM -1.41785913994851 0.0836965748069748 no 3097 0.0781159468838593 4424 6815817 SGTC_793 0488-0545 106 µM -1.42290004437879 0.0829132334023956 no 3098 0.0773825666920337 4464 292548 SGTC_2499 avocadenofuran 51.48 µM -1.42571970222242 0.0824774791752126 no 3099 0.076974633537321 4418 6857792 A insecticide and lysyl oxidase inhibitor. SGTC_56 0957-0365 83.25 µM -1.42959840577349 0.0818808784703118 no 3100 0.0764161566853749 4396 6752360 SGTC_404 fumagillin 50 µM -1.43259912141066 0.0814215607605173 no 3101 0.0759862164939314 4458 12015870 A methionine aminopeptidase binder. SGTC_2580 diallyl disulphide 81.36 µM -1.43390819648101 0.0812217913355946 no 3102 0.0757992312638371 4446 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.  SGTC_2836 9010338 19.48 µM -1.44122335502089 0.0801122743005958 no 3103 0.0747607961594686 4425 2994051 SGTC_1642 st009582 77.7 µM -1.44150493121964 0.0800697967449689 no 3104 0.0747210426043899 4442 6739311 SGTC_1374 2889-5571 141 µM -1.44476086672946 0.0795798543063743 no 3105 0.074262533300587 4465 2853281 SGTC_1418 3966-3099 2.4 µM -1.44635972335555 0.0793400956477268 no 3106 0.0740381662468238 4465 740335 SGTC_1004 4084-0029 199 µM -1.44700030387948 0.0792441901163633 no 3107 0.0739484192299683 4474 716894 YLR208W SEC13 SGTC_1682 st012968 530 nM -1.44982473953496 0.0788223716565469 no 3108 0.0735536993807189 4446 24207270 SGTC_1532 4',5'-dihydroxyflavone 78.7 µM -1.45154782823651 0.0785658718571344 no 3109 0.0733136871286362 4516 165521 SGTC_2744 captopril 92.04 µM -1.45179906541025 0.0785285254824143 no 3110 0.0732787419335387 4534 44093 angiotensin-converting enzyme (ACE) inhibitor  SGTC_3193 9111931 49.47 µM -1.45339602140247 0.0782914527317497 no 3111 0.0730569152517053 4461 17087244 SGTC_3139 9095020 49.47 µM -1.45502592217586 0.0780500493009629 no 3112 0.0728310426272732 4343 25236292 SGTC_143 4032-1194 15.74 µM -1.45551150613832 0.0779782391012191 no 3113 0.0727638535848177 4495 1806963 SGTC_1126 isoteolin 1.0172 µM -1.45938466052906 0.0774072542671381 no 3114 0.0722296327757003 4410 133323 SGTC_1625 st003711 30.1 µM -1.46574175455471 0.0764769754808537 no 3115 0.0713593271407087 4489 24207034 YER133W GLC7 SGTC_2211 7117706 200 µM -1.46910119500652 0.0759888120276256 no 3116 0.0709026718478462 4431 822771 SGTC_2199 6590217 200 µM -1.47085139535281 0.0757354305658277 no 3117 0.0706656548155645 4427 703109 SGTC_1160 4092-0570 10.5 µM -1.47276200810004 0.0754595610587399 no 3118 0.0704076099569995 4496 4994975 SGTC_1817 st052116 64.4 µM -1.48035946081156 0.0743701530696754 no 3119 0.0693886713281275 4509 4361398 SGTC_1301 naphtanilide LB 4.81 µM -1.48184074892528 0.0741591552842732 no 3120 0.0691913368493254 4533 67238 An a1-adrenergic receptor antagonist or alpha blocker. SGTC_2690 usnic acid 100 µM -1.49581743695458 0.0721907407833935 no 3121 0.0673506180701179 4493 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_442 cape 100 µM -1.50446279436448 0.0709933668530239 no 3122 0.0662311231282495 4519 5281787 SGTC_2406 ethylparaben 405.7 µM -1.50629174554253 0.0707420247565061 no 3123 0.0659961481023771 4445 8434 A possible steroid mimic. SGTC_1541 2',3',6-trimethoxyflavone 64 µM -1.50692740843068 0.0706548296127157 no 3124 0.0659146325643942 4572 688801 SGTC_1248 0469-0687 58.6 µM -1.50793988445732 0.0705161168431663 no 3125 0.0657849567574244 4458 4017482 SGTC_558 k064-0027 21.3 µM -1.51091310173988 0.0701099855379202 no 3126 0.0654052961655797 4506 5088526 SGTC_1764 st044502 93.5 µM -1.51173210835887 0.0699984287304619 no 3127 0.0653010134468643 4520 8407 SGTC_3031 9088762 49.47 µM -1.5121655189707 0.0699394492011929 no 3128 0.0652458802265951 4473 205253 SGTC_1677 st019204 53.9 µM -1.51250646611468 0.0698930791953415 no 3129 0.0652025344679724 4503 3945625 SGTC_2835 9006588 71.43 µM -1.51385052286951 0.0697105132030406 no 3130 0.0650318776317825 4473 2345538 SGTC_1748 st037455 53.6035 µM -1.51503832053373 0.0695494779583616 no 3131 0.0648813499862258 4504 580690 SGTC_2582 agaric acid 100 µM -1.51608914881504 0.0694072512254586 no 3132 0.0647484058806492 4101 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase. SGTC_567 1080-0542 68.4 µM -1.51872727783754 0.0690511748528831 no 3133 0.0644155787450536 4392 5950415 SGTC_1005 4092-0690 4.4 µM -1.51896746762358 0.0690188257523742 no 3134 0.0643853424754171 4522 1529343 SGTC_2375 9072683 200 µM -1.52144589288996 0.0686857096640479 no 3135 0.0640739897947065 4555 16798029 SGTC_1460 k062-0059 9.15 µM -1.52310159511461 0.0684638645073821 no 3136 0.0638666449250065 4394 1373085 SGTC_1306 1185-0270 9.02 µM -1.53034388080335 0.0674999730734843 no 3137 0.0629658160114843 4525 1548076 SGTC_1649 st011737 51.3 µM -1.53176419987321 0.0673121756988494 no 3138 0.0627903166920556 4531 1761035 SGTC_976 1348-1067 47.6 µM -1.53512918824717 0.0668688624801845 no 3139 0.0623760489396447 4533 5310671 YGL099W LSG1 SGTC_745 0469-0705 296 µM -1.53972832262474 0.0662666167963097 no 3140 0.0618132950083549 4543 3486736 SGTC_1082 camptothecin 424.86 nM -1.54070738969905 0.0661389542690559 no 3141 0.0616940087481134 4392 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_1547 harmine 94.2 µM -1.54097549951936 0.0661040281396925 no 3142 0.0616613745106549 4427 5280953 A monoamine oxidase inhibitor YHR072W ERG7 SGTC_1455 4262-0120 131 µM -1.54129112470662 0.0660629305910224 no 3143 0.061622973993658 4558 1529587 SGTC_751 0833-0568 350 µM -1.54329217854566 0.0658028338439503 no 3144 0.0613799502454619 4521 6954252 SGTC_2602 kawain 100 µM -1.54507811237431 0.065571369319975 no 3145 0.0611636852514706 4480 5369129 SGTC_1828 st055811 49 µM -1.55480066877761 0.0643223424331031 no 3146 0.0599967749111877 4526 5877589 SGTC_1218 1348-1416 30.7 µM -1.5574645003473 0.0639833754920899 no 3147 0.0596801213270566 4492 6787668 SGTC_565 1418-0001 44.5 µM -1.55825179922781 0.0638834597562526 no 3148 0.0595867850882144 4564 2862145 SGTC_2506 ethyl hematommate 54.16 µM -1.56224339397884 0.0633787544157155 no 3149 0.0591153307495492 4542 3940691 An allergen. SGTC_198 3454-2873 16.191 µM -1.56335420625492 0.063238854566725 no 3150 0.0589846524854477 4530 710957 SGTC_3301 9125354 19.7965 µM -1.56461575099323 0.0630802626356381 no 3151 0.0588365167051186 4500 41905162 SGTC_2171 5739187 198.077 µM -1.5658649665885 0.0629235260341453 no 3152 0.0586901165032779 4498 2262761 SGTC_2763 lisinopril 49.32 µM -1.56627251444203 0.0628724575029241 no 3153 0.0586424163703518 4438 5362119 A lysine-analog of enalapril and an ACE inhibitor. SGTC_2812 7970281 58.44 µM -1.56703257531957 0.062777302956488 no 3154 0.0585535387887103 4553 2233435 SGTC_3322 9139058 2.11 µM -1.56746972000277 0.0627226262158386 no 3155 0.0585024692799532 4558 4908926 YPR165W RHO1 SGTC_1183 1254-0324 198 µM -1.57045998102809 0.0623496080201413 no 3156 0.0581540688000949 4566 5799357 SGTC_2083 5306046 65.942 µM -1.57055238147851 0.0623381091998142 no 3157 0.0581433290857866 4532 539837 SGTC_262 fenpropimorph 62.5 µM -1.57504927797321 0.0617804869128956 no 3158 0.0576225352506622 4563 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_345 1362-0200 395 µM -1.57846981797842 0.0613589478433996 no 3159 0.0572288583321661 4525 1419823 SGTC_2063 5246145 200 µM -1.57939196629174 0.0612456899192177 no 3160 0.0571230894655548 4578 711240 SGTC_1776 st049249 45.9 µM -1.58002119220711 0.0611685024231185 no 3161 0.0570510066689374 4549 1822314 SGTC_2158 5657123 3.6195 µM -1.58048607417477 0.0611115239383013 no 3162 0.0569977967807082 4531 2858827 SGTC_740 k014-0057 261 µM -1.58469847204028 0.0605971184530408 no 3163 0.0565174296070737 4523 4012779 SGTC_1586 deoxycorticosterone acetate 53.7 µM -1.58930584526302 0.0600383649705942 no 3164 0.055995679861698 4544 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE. SGTC_1723 st034307 2.5525 µM -1.59511592808914 0.0593395153759793 no 3165 0.0553431571291587 4540 867466 SGTC_967 1306-0166 352 µM -1.59560770943004 0.0592806568195869 no 3166 0.0552882026052801 4539 4437607 SGTC_1772 st048439 82.2 µM -1.59841809095839 0.0589451758433487 no 3167 0.0549749805428353 4577 2927068 YDL195W SEC31 SGTC_2160 5660466 132.927 µM -1.60072015182388 0.0586714854841445 no 3168 0.0547194578678766 4479 2859134 SGTC_2794 7785382 27.27 µM -1.601038318091 0.0586337375140653 no 3169 0.0546842162253514 4536 2205081 SGTC_2196 6573537 42.6665 µM -1.60213666163527 0.0585035740291825 no 3170 0.0545626962377081 4579 2903087 SGTC_133 0724-0033 378.92 µM -1.60560623463831 0.0580938887519679 no 3171 0.0541802273709343 4459 280309 SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM -1.60593173141424 0.0580555702262894 no 3172 0.0541444553153996 4529 6728940 SGTC_478 N-arachidonylglycine 10 µM -1.60810885547089 0.057799782675897 no 3173 0.0539056700415514 4589 5283389 SGTC_1352 1496-0991 99 µM -1.60997616349527 0.0575811016246214 no 3174 0.0537015300661392 4548 3000039 SGTC_337 1315-0038 354 µM -1.61223485343195 0.0573174559121938 no 3175 0.053455421792354 4536 1626437 SGTC_884 0851-0618 334 µM -1.61451558627914 0.0570522020089903 no 3176 0.0532078194233308 4567 9642473 SGTC_1557 sumaresinolic acid 42.3 µM -1.61631081725448 0.0568440934556698 no 3177 0.0530135646141882 4532 9982268 A natural terpine and antifungal of unknown mechanisn. SGTC_2670 beta-carotene 100 µM -1.61720440665448 0.0567407289839707 no 3178 0.0529170827245937 4545 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.) SGTC_3111 9122088 49.47 µM -1.61774660052896 0.0566780838124694 no 3179 0.0528586093436725 4492 16876704 SGTC_1191 1487-1166 10.6 µM -1.62126771473769 0.0562725786197748 no 3180 0.0524801179466867 4565 3955771 SGTC_3251 9135047 49.47 µM -1.62339369256725 0.0560288523142499 no 3181 0.0522526360981097 4597 17682963 SGTC_3095 9117207 49.47 µM -1.62647390719742 0.0556772083021454 no 3182 0.051924439849976 4568 17015229 SGTC_1061 3448-9325 110 µM -1.62729389846766 0.0555838904746532 no 3183 0.051837346581973 4528 723482 SGTC_2066 5222451 176 µM -1.62729691048443 0.0555835479245009 no 3184 0.0518370268824845 4499 2281147 SGTC_2094 5332512 191.667 µM -1.63296199278223 0.0549422138459662 no 3185 0.0512384952543843 4574 755774 SGTC_935 2996-0153 430 µM -1.63411933538227 0.0548119152929273 no 3186 0.0511168978281675 4571 23738523 SGTC_2851 9015922 71.43 µM -1.63811657831516 0.0543637665025498 no 3187 0.0506986886496264 4562 2996893 SGTC_2852 9023854 51.95 µM -1.64031370651093 0.0541186739942717 no 3188 0.0504699785901281 4566 19798528 SGTC_916 4466-0038 42 nM -1.64169690675425 0.0539648253270148 no 3189 0.0503264165174589 4599 5722064 YGL116W CDC20 SGTC_655 k060-0012 42 µM -1.64606759796803 0.0534809628378403 no 3190 0.0498749212729983 4554 5994525 SGTC_527 4476-4215 268 µM -1.64793833153126 0.0532749144878818 no 3191 0.0496826632679405 4556 4418754 SGTC_3142 9086498 49.47 µM -1.64885139412029 0.0531745757325488 no 3192 0.0495890414788376 4424 25236367 SGTC_3119 9125183 49.47 µM -1.65464449794252 0.0525414433983074 no 3193 0.0489983158043788 4469 22695334 SGTC_1676 st018489 23.4 µM -1.65667413028649 0.0523210441514392 no 3194 0.0487926879860175 4533 3696235 SGTC_3292 9120825 59.784 µM -1.66126680188802 0.0518250325792461 no 3195 0.0483299371838027 4555 24824900 SGTC_245 methotrexate 289.6 µM -1.66535814311303 0.0513863192011578 no 3196 0.0479206624581138 4528 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2 SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM -1.66544435925498 0.051377106147373 no 3197 0.0479120678226504 4573 7104 SGTC_2856 9022925 19.48 µM -1.66658352586464 0.0512554981722899 no 3198 0.0477986234549548 4570 4944862 SGTC_2719 novobiocin 32.65 µM -1.66798923924938 0.0511057516448309 no 3199 0.0476589314726112 4602 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication. SGTC_2751 anetholtrithion 17.25 µM -1.66842155553475 0.0510597683249602 no 3200 0.0476160360844039 4536 2194 A chloretic substance that stimulates the liver to produce bile. SGTC_435 c-PAF 6.7 µM -1.67240424534519 0.0506376969084084 no 3201 0.0472223177671426 4495 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase SGTC_19 0279-0214 38.434 µM -1.67704860776533 0.0501490186321834 no 3202 0.0467664885720564 4644 3566274 YBR002C RER2 SGTC_1096 rimcazole 32.2 µM -1.68150476957899 0.0496836840939274 no 3203 0.0463324553981867 4542 18528119 A dopamine reuptake inhibitor. SGTC_1727 st034309 9.9045 µM -1.69067453619196 0.0487369727379267 no 3204 0.0454494901190201 4593 870305 SGTC_1524 corynanthine 62.1 µM -1.69661440626332 0.0481314580592192 no 3205 0.0448847921869407 4638 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist. SGTC_428 3448-4153 16.5 µM -1.71175685211489 0.0466150377210628 no 3206 0.0434707433372424 4563 3834874 SGTC_409 arachidonic acid 100 µM -1.71713268928827 0.0460859940042208 no 3207 0.0429774653123078 4616 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes. SGTC_3024 9090631 49.47 µM -1.72215667968006 0.0455959460801748 no 3208 0.0425205699489941 4593 25236383 SGTC_2821 7996764 71.43 µM -1.72272486788628 0.0455407887922091 no 3209 0.0424691455321017 4562 2987135 SGTC_1345 1488-0192 31.4 µM -1.72580157682509 0.0452430461796209 no 3210 0.042191558033611 4634 658348 SGTC_3116 9124943 49.47 µM -1.73095513544398 0.0447478308188884 no 3211 0.0417298833273869 4584 41905195 YPL160W CDC60 SGTC_1894 3',6'-dihydroxyflavone 78.7 µM -1.73311976352159 0.0445411335208486 no 3212 0.0415371921421171 4606 688662 SGTC_1230 0170-0365 3.77 µM -1.73330113215809 0.044523849864023 no 3213 0.0415210798274282 4609 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1 SGTC_196 k015-0023 18.111 µM -1.73888655282053 0.0439942232283549 no 3214 0.0410273600033762 4560 5211998 SGTC_3178 9107506 49.47 µM -1.73980073346998 0.0439080236273129 no 3215 0.0409470068303166 4585 8897194 SGTC_992 3909-8734 162 µM -1.74213687221303 0.043688363995015 no 3216 0.0407422484855027 4618 4288319 SGTC_2114 5491910 81.25 µM -1.74361136374155 0.0435501793172722 no 3217 0.0406134402130491 4607 2849228 SGTC_3219 9131112 49.47 µM -1.74648982480391 0.043281435649692 no 3218 0.0403629368210011 4483 17612988 YMR079W SEC14 SGTC_1313 1220-0047 237 µM -1.75119133408076 0.0428453669382711 no 3219 0.0399564788483362 4609 3528706 SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM -1.75151525619187 0.042815454125937 no 3220 0.0399285978503027 4579 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis. SGTC_1013 4112-3890 241 µM -1.76185050980065 0.0418698660144953 no 3221 0.0390472790824008 4594 705171 SGTC_1587 estradiol valerate 56.1 µM -1.77355402479258 0.0408195844566717 no 3222 0.0380684740797738 4652 13791 A steroid. SGTC_2200 6600604 21.907 µM -1.77423153023269 0.0407594451424206 no 3223 0.0380124304047895 4643 2904777 SGTC_2718 lomofungin 53.02 µM -1.7760906887795 0.0405947847113719 no 3224 0.0378589853483541 4576 5351222 A RNA synthesis inhibitor. SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM -1.77633315335175 0.0405733501635001 no 3225 0.0378390109237853 4561 5711223 A potent inhibitor of glutathione S-transferases. SGTC_185 k048-0037 25.491 µM -1.78061353639632 0.0401964626799026 no 3226 0.0374878034368234 4659 6827589 SGTC_1254 0550-0035 264 µM -1.78385702777381 0.0399127714932385 no 3227 0.0372234500658097 4599 15121435 SGTC_759 3486-0358 89.3 µM -1.7889865904703 0.0394674392765674 no 3228 0.0368084875804767 4597 875103 SGTC_439 amiodarone 34.4 µM -1.78936245887857 0.0394349671612247 no 3229 0.0367782305719645 4499 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1 SGTC_610 4215-0184 155 µM -1.79599109816519 0.038865867242444 no 3230 0.0362479663948441 4639 5605015 SGTC_2369 9071472 200 µM -1.79791735630101 0.0387017489673568 no 3231 0.0360950526238398 4631 17296037 SGTC_2843 9000894 45.46 µM -1.80578556761406 0.0380372266459645 no 3232 0.0354759203415521 4642 2242070 SGTC_1672 st016598 6.51 µM -1.81436075881195 0.0373236257856107 no 3233 0.034811101501771 4603 4665860 YNL267W PIK1 SGTC_2710 st078562 53.7235 µM -1.81653494358461 0.0371444454250165 no 3234 0.0346441763490127 4624 17250908 SGTC_1034 k072-0165 12.7 µM -1.8189405224628 0.0369470150550875 no 3235 0.0344602523468231 4636 5835461 SGTC_121 0557-0495 61.343 µM -1.82674651151275 0.0363122639831527 no 3236 0.0338689457464399 4645 3104427 SGTC_102 gallobenzophenone 83.616 µM -1.83606041914718 0.0355666038133809 no 3237 0.0331743606694736 4620 70837 SGTC_1063 disulfiram 1.84 µM -1.83892345971891 0.035339930848816 no 3238 0.0329632223543267 4666 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_1050 3232-1156 69.3 µM -1.8424710039005 0.0350607092877889 no 3239 0.032703142053479 4601 700529 SGTC_1954 st077032 68.9 µM -1.84394560200526 0.0349451799023478 no 3240 0.0325955341583043 4588 698907 SGTC_575 k072-0246 11.9 µM -1.84397043912821 0.0349432366833747 no 3241 0.0325937241882451 4699 6796779 SGTC_1934 st074720 32.6 µM -1.84480738854332 0.0348778068603184 no 3242 0.0325327811312165 4582 17250992 SGTC_1480 1070-0044 41.2 µM -1.85217912652408 0.0343058432672886 no 3243 0.032000052556677 4683 3124987 SGTC_937 3122-0005 46.7 µM -1.85584278669479 0.0340244652668879 no 3244 0.0317379849556575 4619 759535 SGTC_1413 3910-0535 34.4 µM -1.86895509271541 0.0330329190662119 no 3245 0.0308145312173023 4670 2876951 SGTC_343 4130-2827 29.8 µM -1.87552565006677 0.0325450838696798 no 3246 0.0303602220689021 4643 1118244 SGTC_594 1487-1584 10.8 µM -1.88146299050021 0.0321093880453765 no 3247 0.029954482580679 4643 5013332 SGTC_1891 st059073 26.2 µM -1.8884894615373 0.0316000024435884 no 3248 0.0294801356832332 4692 688754 SGTC_1872 amphotericin b 148 nM -1.89459476756442 0.0311628367785601 no 3249 0.0290730542701317 4676 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1 SGTC_1767 st044992 70.3 µM -1.903084827556 0.0305632395564139 no 3250 0.0285147386949945 4659 9600693 SGTC_1841 st054148 70 µM -1.9155779767447 0.0296983323079269 no 3251 0.0277094175161027 4678 675442 SGTC_2176 5809774 33.9695 µM -1.91700252584855 0.029601012813408 no 3252 0.0276188053802929 4606 2870539 SGTC_3001 9076041 71.4286 µM -1.91719202072799 0.0295880872496497 no 3253 0.0276067707001225 4660 16004211 SGTC_803 4488-1585 147 µM -1.91926029494602 0.0294473133311799 no 3254 0.027475700117659 4668 747204 SGTC_1982 st072467 71.9 µM -1.92164309647846 0.0292858213861723 no 3255 0.0273253409423612 4654 3163533 SGTC_3207 9114163 49.47 µM -1.93254093100766 0.028556578404623 no 3256 0.0266463875647353 4632 849233 SGTC_405 ebelactone b 50 µM -1.94308465920318 0.0278654704456588 no 3257 0.0260029651240381 4649 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).  SGTC_3310 9130229 44.1445 µM -1.95483000659394 0.0271120635911638 no 3258 0.0253015690896508 4664 7761258 SGTC_2994 9053520 71.4286 µM -1.95568930681946 0.027057617407144 no 3259 0.0252508825817997 4665 4647384 SGTC_631 k072-0230 41.5 µM -1.96109687088881 0.0267170783905685 no 3260 0.0249338618467153 4682 5773147 SGTC_3124 9127567 49.47 µM -1.96321508303659 0.0265846641317901 no 3261 0.0248105937482105 4642 17592030 SGTC_901 1112-0062 60.1 µM -1.9761244401639 0.0257894717172413 no 3262 0.0240703424926245 4695 1908457 SGTC_1881 5652484 16 µM -1.97974306511915 0.0255701767988121 no 3263 0.0238662034227136 4653 2255129 SGTC_1496 4469-0713 57.4 µM -1.98483630664336 0.025264164702159 no 3264 0.0235813433227699 4713 746691 SGTC_2725 haloperidol 53.21 µM -1.99029789426469 0.0249394370438817 no 3265 0.0232790649236892 4658 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_1508 1080-0625 72.9 µM -1.99046125781908 0.0249297781544865 no 3266 0.0232700738330872 4651 767111 SGTC_3216 9129716 49.47 µM -1.99710123996963 0.0245398349342175 no 3267 0.0229070931375924 4605 8056934 SGTC_825 1988-2224 89.6 µM -1.99789995316548 0.024493276041027 no 3268 0.0228637538673902 4674 1180859 SGTC_41 0478-0632 82.643 µM -2.00036406171922 0.0243501042608687 no 3269 0.0227304830587986 4654 3750424 SGTC_2567 aureobasidin a 60 nM -2.00938319652091 0.0238320456489281 no 3270 0.0222482554330934 4702 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1 SGTC_2401 5128683 200 µM -2.00952801253587 0.0238238035962337 no 3271 0.0222405834922215 4654 708373 SGTC_2638 epoxomicin 18 µM -2.01536421041291 0.0234936310808078 no 3272 0.0219332507735631 4668 9915668 A protesome inhibitor. SGTC_1454 4239-0054 42.6 µM -2.01740716060644 0.0233789681612778 no 3273 0.0218265203126921 4720 1340767 SGTC_2729 fluphenazine 10.66 µM -2.0238315658863 0.0230214556072054 no 3274 0.0214937425776014 4668 3372 An atypical antipsychotic. SGTC_2676 harmalol 100 µM -2.03115182835715 0.0226197127115691 no 3275 0.0211197976312542 4696 5459187 A monoamine oxidase inhibitor SGTC_116 0155-0182 31.788 µM -2.03650276874195 0.0223298010918213 no 3276 0.020849947680711 4571 771486 SGTC_3137 9097352 49.47 µM -2.07519167662848 0.0203255246889827 no 3277 0.018984386868275 4655 44120435 SGTC_763 3453-1109 128 µM -2.0848920852537 0.0198476098335866 no 3278 0.0185395486391454 4721 1560353 SGTC_2137 5261020 140 µM -2.0879813907404 0.019697423882052 no 3279 0.0183997566882284 4686 763655 SGTC_1594 piperine 70.1 µM -2.09463970936096 0.0193770092477421 no 3280 0.0181015162316472 4692 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_522 1273-0010 11.6 µM -2.09470642304579 0.0193738213639832 no 3281 0.0180985489568879 4698 5705015 SGTC_608 k048-0125 159 µM -2.10214197103721 0.0190212986939586 no 3282 0.0177704206169876 4726 6817652 YLR060W | YFL022C FRS1 | FRS2 SGTC_2127 5253358 187.912 µM -2.10339297317431 0.018962527467494 no 3283 0.0177157160942921 4649 20612 SGTC_2275 7947463 200 µM -2.10798416329238 0.0187481582713938 no 3284 0.0175161796567422 4671 1225414 SGTC_1888 azatryptophan 97.5 µM -2.12429783429537 0.0180030556011393 no 3285 0.0168226233575228 4718 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides SGTC_417 st075190 100 µM -2.12461560469892 0.0179887962956468 no 3286 0.0168093503505011 4703 222757 SGTC_1201 1889-3372 45.9 µM -2.15506763072899 0.0166662757635841 no 3287 0.0155782711371521 4645 5392199 SGTC_2148 5546263 113.568 µM -2.19329899787239 0.0151244470778693 no 3288 0.0141429219031678 4745 792097 SGTC_2463 5473429 200 µM -2.19397665200975 0.0150982624353914 no 3289 0.0141185440485604 4735 5399405 SGTC_2336 9001819 198.65 µM -2.20843539942034 0.0145487859534977 no 3290 0.0136069682081644 4688 2989602 SGTC_2603 homopterocarpin 100 µM -2.21522774124609 0.014296654865888 no 3291 0.0133722183402276 4698 101795 A weak amylase inhibitor. SGTC_2192 5915882 198.485 µM -2.21806669814508 0.0141923934867382 no 3292 0.0132751425217148 4734 2876149 SGTC_2461 5755302 26.15 µM -2.22870078751962 0.0138076556151348 no 3293 0.012916909915988 4721 2788904 SGTC_817 1391-0715 46 µM -2.23050356615143 0.0137433314448655 no 3294 0.0128570154861939 4734 1353946 SGTC_2347 9049783 174.81 µM -2.23170088482689 0.0137007534269222 no 3295 0.0128173693683494 4700 6467988 YPL169C MEX67 SGTC_1084 voriconazole 435 nM -2.23289059073169 0.0136585588986591 no 3296 0.0127780801166433 4755 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_346 4513-0042 7.16 µM -2.23609177223859 0.0135455809893855 no 3297 0.0126728801489512 4697 2827372 SGTC_864 0469-0573 172 µM -2.24917417045385 0.0130922139963467 no 3298 0.0122507085614708 4721 689425 SGTC_808 0711-0032 135 µM -2.26600404659783 0.0125283123989053 no 3299 0.0117255677437762 4721 4252555 SGTC_3009 9080819 71.4286 µM -2.26691562016559 0.0124983788858999 no 3300 0.0116976904135075 4742 17027216 SGTC_2443 5493264 126.67 µM -2.29337299831838 0.0116561675512124 no 3301 0.0109132699042904 4754 5340055 SGTC_3318 9139014 38.6185 µM -2.31652530294049 0.0109600342346188 no 3302 0.0102648022666693 4734 16643984 SGTC_2361 9034121 116 µM -2.35633608414925 0.00984738338895505 no 3303 0.00922810552771561 4748 6496917 SGTC_2129 girgensonine 121.053 µM -2.37042821009511 0.00947787429951595 no 3304 0.00888374701610566 4723 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_415 dibenzyl ketone 100 µM -2.37789470502577 0.00928705387369978 no 3305 0.00870589855025659 4745 7593 SGTC_406 estrone 100 µM -2.37929188824001 0.00925172202300951 no 3306 0.00867296729188279 4734 5870 A steroid. SGTC_199 4063-0024 41.6 µM -2.38226055639557 0.00917704088139477 no 3307 0.00860335896708651 4781 306215 SGTC_2008 4012253 172 µM -2.38450088088445 0.00912103217862797 no 3308 0.00855115353167697 4730 603940 SGTC_1972 st070201 17.4 µM -2.41510638077606 0.00838532997516597 no 3309 0.00786530728993664 4761 2829099 SGTC_2150 5556613 200 µM -2.41750622384165 0.0083299085082528 no 3310 0.0078136333712819 4769 743190 SGTC_766 1391-0721 126 µM -2.43443937610573 0.00794791837773273 no 3311 0.00745743903519006 4763 1020919 YIL115C NUP159 SGTC_147 4466-0538 29.23 µM -2.44897669557243 0.00763235256685702 no 3312 0.00716313585216868 4736 6742687 YHR072W ERG7 SGTC_979 1426-2828 121 µM -2.46748361209615 0.00724661183971172 no 3313 0.00680332247700475 4771 747872 SGTC_648 0375-0473 33.3 µM -2.49178959974688 0.00676616959570021 no 3314 0.00635506519742002 4776 1713139 SGTC_918 glabranin 770.725 nM -2.49588726289905 0.00668800674788281 no 3315 0.00628212629155389 4746 124049 Also referred to as licorice root. SGTC_3248 9135562 49.47 µM -2.52410960388897 0.00617100963239443 no 3316 0.00579958791283237 4759 17650701 SGTC_1106 tegaserod maleate 11.7 µM -2.5285845243589 0.0060923708852767 no 3317 0.00572617535034753 4769 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation. SGTC_2642 cholecalciferol 100 µM -2.53121350230648 0.00604658652272339 no 3318 0.00568343177286698 4767 9821465 A vitamin D precursor, similar to steriods. SGTC_899 1083-0020 478 µM -2.53613435803537 0.00596170745683876 no 3319 0.0056041860956129 4774 767123 SGTC_989 1501-0895 10.3 µM -2.55069868160951 0.00571664754496506 no 3320 0.0053753613901705 4768 2830112 SGTC_2474 5321570 43.32 µM -2.57428870090134 0.00533865650242628 no 3321 0.00502232096875638 4767 2841384 SGTC_897 1000-0139 31.4 µM -2.5754060007448 0.00532131805911266 no 3322 0.00500612418775195 4752 6151020 SGTC_413 propylparaben 100 µM -2.61934313829514 0.00467799168141113 no 3323 0.00440496398254342 4767 7175 A pharmaceutical preservative. SGTC_931 2812-0076 566 µM -2.62654172657171 0.00457947759612269 no 3324 0.00431287080413192 4741 3450959 SGTC_2837 9008476 45.46 µM -2.63360600778795 0.00448460611211408 no 3325 0.0042241729187766 4746 2992805 SGTC_349 k015-0014 24 µM -2.64892637634354 0.00428486451278888 no 3326 0.0040373960174894 4776 2196908 SGTC_523 1934-0222 13.7 µM -2.66235061941707 0.00411642233963946 no 3327 0.00387985016665494 4767 1361595 SGTC_1343 1487-0095 224 µM -2.67211283352172 0.00399767703939511 no 3328 0.00376876494023837 4760 4560101 YGL055W OLE1 SGTC_622 1348-1566 26.3 µM -2.68794882324889 0.0038115646982514 no 3329 0.00359462070284723 4786 7340407 SGTC_1922 5578187 25 µM -2.69105500339355 0.00377598393611783 no 3330 0.0035613225241141 4767 1350412 SGTC_3314 9135860 59.4275 µM -2.6966214062949 0.00371296605664419 no 3331 0.00350234291752309 4769 25252478 SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM -2.73001639358108 0.00335431433415504 no 3332 0.00316655880747345 4771 688798 SGTC_421 streptovitacin 30 mM -2.73834394973474 0.00326987508712797 no 3333 0.00308747288513089 4767 91467 include heat shock SGTC_2362 9071156 126 µM -2.7505864387358 0.00314920865448613 no 3334 0.00297443471588646 4769 653133 SGTC_634 1611-4317 11.2 µM -2.77480001482297 0.00292228548875536 no 3335 0.00276178308329601 4793 2843522 SGTC_2077 5212015 200 µM -2.77726370889297 0.00290004317882852 no 3336 0.00274093412738254 4770 780900 SGTC_194 1486-1323 56.904 µM -2.78479703937764 0.00283297577196357 no 3337 0.00267806187436231 4799 5178754 SGTC_3253 9135987 49.47 µM -2.81278567891555 0.00259588121567843 no 3338 0.00245571872077197 4789 4182430 SGTC_2600 tangeritin 87.95 µM -2.82008346279911 0.00253708247963708 no 3339 0.00240055800619547 4763 68077 A bioactive flavone. SGTC_855 0428-0020 25 µM -2.86995141714188 0.00216647731050068 no 3340 0.00205267435253491 4789 6812414 SGTC_2955 9076254 12.21 µM -2.89884853727164 0.00197489514277493 no 3341 0.00187267887461591 4771 16459619 SGTC_1991 st073000 8.92 µM -2.97012089028314 0.00156636656761436 no 3342 0.00148841289123853 4791 4301969 YIL048W NEO1 SGTC_2816 7982706 58.44 µM -3.04812488107273 0.00120871608065263 no 3343 0.00115137105081202 4767 2981853 SGTC_2522 biochanin a 4.94 µM -3.08598045980594 0.00106361305590824 no 3344 0.00101441077205411 4784 5280373 A possible chelator. SGTC_3117 9124945 49.47 µM -3.09672700178919 0.00102543480302236 no 3345 0.000978349914407869 4786 17592065 SGTC_1935 st074532 41.6 µM -3.32251573747895 0.000463682480939625 yes 3346 0.000446048194822794 4789 2829742 SGTC_807 1315-0151 48 µM -3.34573201263938 0.000426157783590443 yes 3347 0.000410328348085637 4793 4011080 SGTC_3096 9117468 49.47 µM -3.37992753024551 0.000375990015226673 yes 3348 0.000362524723768979 4803 41316311 SGTC_1010 4112-3296 15.2 µM -3.39038367965933 0.000361781204965037 yes 3349 0.000348974332497908 4803 704384 SGTC_1885 st057546 99.9 µM -3.58531937055691 0.000173031187974318 yes 3350 0.000168332977381786 4804 702008 SGTC_2595 hexamethylquercetagetin 100 µM -3.6213067814481 0.000150396912246557 yes 3351 0.000146559340671862 4793 386331 SGTC_2330 7979373 200 µM -3.63609009735975 0.000141928395937125 yes 3352 0.000138403774992132 4790 1863007 SGTC_3205 9113483 49.47 µM -3.67326386944426 0.000122566123667406 yes 3353 0.000119735984429429 4792 17018033 SGTC_797 k781-0471 270 µM -3.67613571042669 0.000121178376792252 yes 3354 0.000118396794299172 4804 23738129 SGTC_2828 7998861 71.43 µM -4.91520806936706 4.18685754796695e-07 yes 3355 4.43441080234578e-07 4808 2988188 SGTC_3308 9128332 17.569 µM -5.02105825506077 2.40467157794045e-07 yes 3356 2.56937850114662e-07 4804 17332805 YDL196W YDL196W