SGTCid condition conc unit GTO1|YGR154C.score GTO1|YGR154C.strain.pval GTO1|YGR154C.strain.significant GTO1|YGR154C.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene SGTC_2954 9074818 52.69 µM 5.68044681791844 2.49290709076564e-09 yes 1 6.71716601982503e-09 13 16648742 SGTC_3071 9117417 49.47 µM 5.14043098245971 6.06489645284919e-08 yes 2 1.37054499058529e-07 8 45595590 YGL055W OLE1 SGTC_1259 0671-0132 43 µM 4.7472650957178 5.12853640933341e-07 yes 3 1.03092818005481e-06 8 X1259 SGTC_1855 st056195 39.6 µM 4.54511159664032 1.4451822304842e-06 yes 4 2.74530779885982e-06 7 4028379 SGTC_766 1391-0721 126 µM 4.27968293717393 5.28630043765748e-06 yes 5 9.35798738324268e-06 9 1020919 YIL115C NUP159 SGTC_245 methotrexate 289.6 µM 4.10447025495562 1.19639131598065e-05 yes 6 2.02621202702562e-05 43 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2 SGTC_763 3453-1109 128 µM 4.03283465625444 1.65577412996145e-05 yes 7 2.75540274128317e-05 13 1560353 SGTC_1262 0737-0114 49.6 µM 3.97040239782049 2.18854231402551e-05 yes 8 3.58756725962691e-05 19 765919 SGTC_1861 st057647 17.4 µM 3.80409260713061 4.51367604778243e-05 yes 9 7.11624660710584e-05 24 688668 SGTC_935 2996-0153 430 µM 3.80043934535772 4.58458370198798e-05 yes 10 7.22198854135757e-05 22 23738523 SGTC_777 1315-0167 517 µM 3.74884933962464 5.70521651513159e-05 yes 11 8.88238795831203e-05 34 4221767 SGTC_50 0929-0078 56.389 µM 3.6997825747944 7.00677214862163e-05 yes 12 0.000107892128574028 57 1377751 SGTC_536 3852-0578 10.6 µM 3.66635009982831 8.04866563419958e-05 yes 13 0.000123018515997042 36 2869208 SGTC_959 1222-0044 107 µM 3.63994743555196 8.97273961452728e-05 yes 14 0.00013634685149883 28 6083612 SGTC_3242 9133940 49.47 µM 3.55303175864801 0.000127690229223763 yes 15 0.000190409243353713 18 17248444 SGTC_595 3909-8003 73.7 µM 3.54222206998023 0.000133347465449234 yes 16 0.00019838564685989 22 699517 SGTC_2796 7949634 45.45 µM 3.50455508958758 0.000154949798103331 yes 17 0.000228685464554849 34 2971588 SGTC_1731 st035964 63 µM 3.47591321935183 0.00017352422359473 yes 18 0.000254558500002169 47 6739575 SGTC_1737 st035557 69.7 µM 3.35887872503814 0.000273252805994723 yes 19 0.000391297018450483 28 5716916 SGTC_2935 9038016 29.96 µM 3.24947450143203 0.00041260779390598 yes 20 0.000578092215227152 48 6463195 SGTC_1925 st057770 10.1 µM 3.16965985980877 0.000553143226892568 yes 21 0.000763087399831947 47 5989122 SGTC_1718 roemerine 11.9335 µM 3.16212737281491 0.000568472471845106 yes 22 0.000783105205223033 103 235224 An aporphine alkaloid with mutagenic activity. SGTC_3356 9151811 4.48 µM 3.12282122110198 0.000655031518695925 yes 23 0.000895632593887402 51 1859254 YPR165W RHO1 SGTC_318 1488-0629 67.2 µM 3.08658261482435 0.000745454725497357 yes 24 0.001012358372445 54 3662576 SGTC_973 1325-0077 65.9 µM 3.06252248234327 0.000811698984553786 yes 25 0.00109739993836975 42 2835149 SGTC_2035 5154463 94.595 µM 3.04562647708816 0.000861411390283791 yes 26 0.00116098048477221 52 2769623 SGTC_739 1486-1183 203 µM 3.04229770578932 0.000871529725640688 yes 27 0.00117389783273875 45 4346692 SGTC_1977 st070720 65.3 µM 3.02530806130049 0.000924895816251471 yes 28 0.001241899991692 44 682188 SGTC_3329 9141233 27.5565 µM 3.02132568897899 0.0009378316309965 yes 29 0.00125835249041371 40 4909101 YNL103W MET4 SGTC_1098 clofazimine 15.1 µM 2.98187360997304 0.00107526280089085 no 30 0.00143245123075571 78 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2 SGTC_3200 9114385 49.47 µM 2.96721341080999 0.00113087168375833 no 31 0.0015025614634861 91 17018030 YLR208W SEC13 SGTC_1675 st018485 24.5 µM 2.89442221147326 0.00144804255484174 no 32 0.00189928507756 87 3323024 SGTC_1031 k035-0009 16 µM 2.88871639812459 0.00147605182296202 no 33 0.00193408884880017 89 5180959 SGTC_415 dibenzyl ketone 100 µM 2.88389868887405 0.00150008545817037 no 34 0.00196392547701174 48 7593 SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM 2.88306903358628 0.00150426012986246 no 35 0.00196910561858257 26 4000243 SGTC_358 0075-0058 9.45 µM 2.8826896702441 0.00150617254460423 no 36 0.00197147839146565 145 1069125 SGTC_1650 st011916 45.8 µM 2.87806139385965 0.00152968347753976 no 37 0.00200063630006531 43 242528 SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM 2.82964459250356 0.00179648264462197 no 38 0.00232998689758995 57 803109 SGTC_1741 st038134 10.228 µM 2.8081824905775 0.00192776109483919 no 39 0.00249109924910499 93 1272587 SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM 2.80439471439283 0.00195181493202479 no 40 0.00252055744246057 64 689007 SGTC_234 nsc-17383 10.7 µM 2.79083405310594 0.00204018199979514 no 41 0.00262862093845035 83 408974 SGTC_3061 glucosamine 200 µM 2.78649437732125 0.00206921882311404 no 42 0.00266407712143924 55 91431 and experimental redox chemotherapeutic SGTC_1447 4239-0816 81.9 µM 2.77224881554565 0.00216719111472931 no 43 0.00278352328747158 94 1341554 SGTC_2064 5220758 200 µM 2.771055362029 0.00217558691499685 no 44 0.00279374629388006 109 788518 SGTC_3194 9111903 49.47 µM 2.76742335896171 0.00220131934037368 no 45 0.00282506643568006 82 17087251 SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM 2.76059985132068 0.00225041047992046 no 46 0.00288476590950737 61 17037758 SGTC_2369 9071472 200 µM 2.74471057102158 0.00236859043497597 no 47 0.00302821429150688 75 17296037 SGTC_326 k292-0812 17.5 µM 2.72990741320144 0.00248371715015038 no 48 0.00316760575973539 44 3579357 SGTC_2764 methyldopa 94.69 µM 2.71456907777165 0.00260832206532647 no 49 0.00331810293738158 99 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent. SGTC_2823 7987624 58.44 µM 2.67744444307547 0.00293361193405717 no 50 0.00370930773429742 131 2239440 SGTC_1305 1181-0477 144 µM 2.65310030529684 0.00316632247429866 no 51 0.00398780830643268 90 6252086 SGTC_3315 9136395 68.55 µM 2.6523115317839 0.00317413295011291 no 52 0.00399713720077281 77 16876844 SGTC_773 4358-1457 44.6 µM 2.64604374107027 0.00323681582729531 no 53 0.00407196425120061 130 1186886 SGTC_2969 9091408 28.7 µM 2.63855634336562 0.00331315395876394 no 54 0.00416299317163434 118 4286311 SGTC_159 3970-0959 50 µM 2.6374102567311 0.00332498073259174 no 55 0.00417708637061181 221 6615653 SGTC_2504 purpurogallin 52.29 µM 2.6334474050261 0.00336616753850246 no 56 0.00422614626903947 90 5281571 An antioxidant. SGTC_361 000s-0510 1.45 µM 2.63161988205749 0.0033853154375636 no 57 0.00424894403073117 132 660 SGTC_2636 apigenin dimethyl ether 100 µM 2.58868356871484 0.003864279740142 no 58 0.00481717904378028 155 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_607 4491-0986 66.8 µM 2.57746677006345 0.00399902017947381 no 59 0.00497637252896026 105 698981 YDR232W HEM1 SGTC_3010 9080089 71.4286 µM 2.57555608374388 0.00402238685140058 no 60 0.00500395207863055 94 17027233 SGTC_3075 9116269 49.47 µM 2.56192229041588 0.00419269948253658 no 61 0.00520473033831251 95 17015205 YNL244C SUI1 SGTC_418 lividomycin a 100 µM 2.55995662140339 0.00421777939183426 no 62 0.00523426146485091 87 72394 An antibiotic. SGTC_2493 resveratrol 26.09 µM 2.54489662081474 0.00441442391006326 no 63 0.00546550473974681 69 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase. SGTC_1610 st001799 48.1 µM 2.51502133124504 0.00482891671937269 no 64 0.005951259100848 82 621897 SGTC_692 k241-0027 77.8 µM 2.50859719715929 0.00492245307007193 no 65 0.00606058079240702 84 3600480 SGTC_2006 4011487 200 µM 2.47806907782016 0.0053893697845932 no 66 0.00660477840496509 197 45595294 SGTC_2827 7993847 71.43 µM 2.44785937573854 0.00588976599796236 no 67 0.00718538657242074 114 2985692 SGTC_1131 3454-3128 32.3 µM 2.44691778975739 0.00590600392331973 no 68 0.00720418497470113 170 710982 SGTC_3203 9113543 49.47 µM 2.4462256663881 0.00591796509854759 no 69 0.00721803059799542 138 17018012 SGTC_1069 diphenylcyclopropenone 8.49 µM 2.43343126442579 0.00614297855516371 no 70 0.0074782374201964 155 65057 A dermal irritant. YDR527W RBA50 SGTC_842 0271-0008 11.1 µM 2.41845443651464 0.00641597691893458 no 71 0.00779329872742332 117 1221709 SGTC_2161 5662504 8.5105 µM 2.41616770006373 0.00645859102709263 no 72 0.00784241778370363 130 2859334 SGTC_3131 9127911 49.47 µM 2.41205421248293 0.00653587795718927 no 73 0.00793146132903929 131 45595681 SGTC_108 0509-0257 621.132 µM 2.40337366110979 0.00670166327485525 no 74 0.00812228954969947 188 536624 SGTC_1088 bifonazole 369 nM 2.39844729181031 0.00679739327206558 no 75 0.00823237295097285 106 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase. SGTC_2158 5657123 3.6195 µM 2.39256338566257 0.0069133118075358 no 76 0.00836556892322065 84 2858827 SGTC_1638 st008370 60.6 µM 2.38628017385751 0.00703902098255216 no 77 0.00850988957250656 159 24207134 SGTC_539 4859-0462 2.54 µM 2.36961984801193 0.00738216382193439 no 78 0.00890319152525477 140 46499474 YNL221C | YBR257W POP1 | POP4 SGTC_2845 9003024 42.97 µM 2.35183441002886 0.0077646689348506 no 79 0.00934054457352254 192 2990173 SGTC_2825 7998094 58.44 µM 2.33530450211978 0.00813569952763977 no 80 0.00976375957687473 150 2987815 SGTC_252 miconazole 1.30953 nM 2.33500288990667 0.00814261182565339 no 81 0.00977163488429448 166 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_1404 3909-7820 48.3 µM 2.31491766268638 0.00861469253801438 no 82 0.0103087192735594 118 23741373 SGTC_1413 3910-0535 34.4 µM 2.28179662479526 0.00944569461706706 no 83 0.0112506750776403 129 2876951 SGTC_3238 9133470 49.47 µM 2.26971999654669 0.0097656893019372 no 84 0.0116122886752827 107 3534688 SGTC_2952 9073731 13.78 µM 2.26879430091158 0.00979060373824426 no 85 0.0116404188576149 205 16457353 SGTC_1063 disulfiram 1.84 µM 2.2211654114343 0.0111497198515587 no 86 0.013169879987144 168 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_700 3453-2283 142 µM 2.21975559945942 0.0111923335579027 no 87 0.0132176811987941 200 565664 SGTC_2663 amphotericin b 100 µM 2.21639455122523 0.0112944979504781 no 88 0.0133322462701879 124 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_135 0933-0004 26.348 µM 2.205144968005 0.0116423657168142 no 89 0.0137219617213377 185 21230617 YGL099W LSG1 SGTC_1760 st045453 10.4495 µM 2.20282758420379 0.0117151698451063 no 90 0.013803451592622 278 3323419 YIL048W NEO1 SGTC_2820 7989630 71.43 µM 2.18882433232467 0.0121635664520564 no 91 0.0143048052375258 133 2984098 SGTC_2381 9035592 200 µM 2.18844223984369 0.0121760070684886 no 92 0.0143187021450553 154 4749657 SGTC_2164 5685496 200 µM 2.15857156040247 0.0131833273916001 no 93 0.0154417105562156 160 759046 SGTC_616 4092-0450 108 µM 2.14781068422878 0.0135634582278393 no 94 0.0158643989565997 198 787165 SGTC_2116 5511452 16.8835 µM 2.14724704875041 0.0135836269133006 no 95 0.0158868094459986 182 870744 SGTC_2588 indole-3-carbinol 100 µM 2.12886449796385 0.0142557517622955 no 96 0.0166327363940522 249 3712 Induces cell cycle arrest. SGTC_1009 4106-0057 9.87 µM 2.12212059099699 0.0145094147922274 no 97 0.0169138063408093 166 2928005 SGTC_410 α-linolenic acid 100 µM 2.12090178687982 0.0145556706124942 no 98 0.0169650341353177 185 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_3334 9142812 21.919 µM 2.09950415259802 0.0153886607408045 no 99 0.0178862410723727 199 45283678 SGTC_2921 7974240 10.71 µM 2.08930054332715 0.0158000818812896 no 100 0.0183403387604253 223 2979074 YDR527W RBA50 SGTC_2282 7944268 200 µM 2.07587641953808 0.0163556999575172 no 101 0.0189526910678816 238 2970414 SGTC_977 1348-1378 135 µM 2.0746822201611 0.0164059280246072 no 102 0.0190079981406216 200 X977 SGTC_3012 9080433 71.4286 µM 2.07410147802221 0.0164304017520676 no 103 0.0190349436748239 180 17688859 SGTC_2021 4019055 173 µM 2.06559990805678 0.0167922698966405 no 104 0.0194331365659482 384 44827708 YER133W GLC7 SGTC_417 st075190 100 µM 2.05544967201723 0.0172332215234562 no 105 0.0199177959940843 196 222757 SGTC_355 1311-2252 105 µM 2.05199567538994 0.0173855106126501 no 106 0.0200850413511718 225 5338538 SGTC_546 peri-Naphthalide 147 µM 2.04303859299489 0.0177857989045114 no 107 0.0205243089352418 203 223824 A penicillin ester. SGTC_2799 7812892 81.82 µM 2.02835183342866 0.0184591567974109 no 108 0.0212621761481865 230 20205235 SGTC_1885 st057546 99.9 µM 2.02477931277426 0.0186261940761111 no 109 0.0214450151143795 219 702008 SGTC_962 1254-0300 21.5 µM 2.02258944340156 0.0187292186758693 no 110 0.0215577467432302 185 7340576 SGTC_320 4092-0846 5.34 µM 2.00928445340334 0.0193656447523304 no 111 0.0222534878430349 215 1359356 SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM 2.00775027966645 0.0194401979169625 no 112 0.0223349173736722 218 6312947 SGTC_992 3909-8734 162 µM 2.00021169331655 0.0198100876083174 no 113 0.0227387048407124 201 4288319 SGTC_1215 3852-0577 11.2 µM 1.98971735883408 0.0203349374939087 no 114 0.0233110396940441 224 2884876 SGTC_1782 st039423 80.636 µM 1.9891715658809 0.020362553510467 no 115 0.0233411346194477 229 2068169 SGTC_1637 st007924 17.4 µM 1.98625262963767 0.0205107859338397 no 116 0.0235026398212196 221 683336 SGTC_1297 1068-0111 14.1 µM 1.98588891751711 0.0205293202376873 no 117 0.0235228297842521 192 767057 SGTC_1790 st045711 43.5 µM 1.98231886921309 0.0207119997118524 no 118 0.0237217817269748 197 585119 SGTC_2638 epoxomicin 18 µM 1.97785963091414 0.0209421109824812 no 119 0.023972272081042 240 9915668 A protesome inhibitor. SGTC_1296 1068-0102 11.9 µM 1.9745100957052 0.0211163777929498 no 120 0.0241618853155336 204 767053 SGTC_540 1187-0821 17.3 µM 1.97072680859943 0.0213146853832481 no 121 0.0243775661998008 229 847520 SGTC_3081 9117243 49.47 µM 1.96588408443253 0.0215708212560826 no 122 0.0246560009650296 207 45595589 SGTC_1922 5578187 25 µM 1.96235740476374 0.0217589831260053 no 123 0.0248604441068325 255 1350412 SGTC_3277 9138724 49.47 µM 1.96234168328225 0.0217598250214982 no 124 0.0248613586611888 167 15943418 SGTC_2797 7859098 81.82 µM 1.96160350550016 0.0217993859077756 no 125 0.0249043319182601 251 972681 SGTC_736 0958-0254 92.6 µM 1.957027671216 0.0220459746876476 no 126 0.0251721075605936 270 6812352 SGTC_3137 9097352 49.47 µM 1.95699817719622 0.0220475717073522 no 127 0.0251738413322738 281 44120435 SGTC_33 0986-0033 35.816 µM 1.9519943043451 0.0223199349966539 no 128 0.0254694404171116 182 2848082 SGTC_356 1634-0012 32.5 µM 1.95035135421673 0.0224099782851023 no 129 0.0255671278421893 249 735457 SGTC_971 1315-0384 26.7 µM 1.9434762583152 0.0227901041713031 no 130 0.0259793206210315 245 6769120 SGTC_1871 st057448 67.3 µM 1.9406833096611 0.02294607162671 no 131 0.0261483510253516 262 691747 SGTC_782 0083-0095 30.5 µM 1.93948863480096 0.0230130602374544 no 132 0.0262209335499695 285 3591729 An indicator and reagent. SGTC_1030 k029-0042 36.7 µM 1.93868575608867 0.0230581722721706 no 133 0.0262698070644934 277 6080581 SGTC_1474 0330-0125 5.35 µM 1.93293688437832 0.0233833696073527 no 134 0.026621986711619 217 X1474 SGTC_912 3474-0017 2.18 µM 1.93176897652445 0.0234499043538704 no 135 0.0266940134175758 249 3360550 SGTC_54 0159-0055 9 µM 1.92137788981629 0.0240489188691357 no 136 0.0273420419585356 234 3319099 SGTC_3182 9108849 49.47 µM 1.91345086986769 0.02451448645061 no 137 0.0278451786933564 278 17133045 SGTC_440 fluspirilene 35.1 µM 1.90965816046307 0.0247399005262086 no 138 0.0280886206761491 257 3396 An atypical antipsychotic. SGTC_1166 k206-0078 225 µM 1.907512909169 0.0248681684725346 no 139 0.0282271004917959 279 5404595 SGTC_2443 5493264 126.67 µM 1.90695814711415 0.0249014291799318 no 140 0.0282630037163723 232 5340055 SGTC_922 1866-0035 480 µM 1.90018411768993 0.0253105829614569 no 141 0.0287044808966998 330 3156169 SGTC_1434 4073-0095 163 µM 1.89920227555197 0.0253703513365854 no 142 0.0287689428378997 227 24133745 SGTC_1358 1509-0022 2.48 µM 1.89888587827318 0.025389636783234 no 143 0.028789741234765 245 3258434 SGTC_1907 st060210 83.7 µM 1.89814915836717 0.0254345898551815 no 144 0.0288382180145434 285 688793 SGTC_2102 5377816 72.7585 µM 1.89691397777274 0.0255101074997156 no 145 0.0289196461676836 257 1379702 SGTC_2753 fluvastatin 17.09 µM 1.89432850780005 0.0256687883838317 no 146 0.0290907096653752 284 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5 SGTC_184 1494-0393 24.714 µM 1.88674401847792 0.0261390536393935 no 147 0.029597382002917 303 3090647 SGTC_1003 4049-0218 100 µM 1.88469553216957 0.0262672957527417 no 148 0.0297354779609232 288 295161 SGTC_2691 st077356 60.2 µM 1.88162326004582 0.0264606159866796 no 149 0.029943592892953 270 2839272 SGTC_232 clozapine 119 µM 1.86349771598888 0.0276254982092776 no 150 0.0311961367934272 290 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_1558 st069300 45.6 µM 1.86187168945086 0.027732056462801 no 151 0.0313105892143689 174 24208000 SGTC_1747 st037496 66.6 µM 1.86053261008043 0.027820067207978 no 152 0.0314051045921952 288 723305 SGTC_577 r071-0003 38.6 µM 1.86022734129062 0.0278401634816533 no 153 0.0314266841682848 377 4568517 YMR134W ERG29 SGTC_552 k242-0005 476 µM 1.85960341563592 0.0278812750060603 no 154 0.0314708278636857 231 4088318 SGTC_374 0880-0231 82.3 µM 1.8584250244647 0.027959059167408 no 155 0.0315543406748045 270 6833587 SGTC_917 harmaline 728.087 nM 1.85685730786943 0.0280628223246623 no 156 0.0316657289205998 293 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7 SGTC_2397 5161689 200 µM 1.85326290970401 0.0283019372176635 no 157 0.0319223423084218 292 2259942 SGTC_2703 st077852 53.4 µM 1.85046729513078 0.0284890837769691 no 158 0.0321231137839626 273 6281836 SGTC_1678 st019265 80.2 µM 1.8395585199174 0.0292292224154179 no 159 0.0329165394701012 308 5367020 SGTC_873 0591-4978 488 µM 1.83824041909273 0.0293197248715529 no 160 0.0330134931386038 275 3305145 SGTC_3259 9138485 49.47 µM 1.83592899887533 0.0294789916983874 no 161 0.0331840790943229 292 17646153 SGTC_3128 9127691 49.47 µM 1.82204466217997 0.0304508647292926 no 162 0.0342241046014575 233 41316314 SGTC_2469 5655019 90.81 µM 1.81033159742043 0.0312912598052323 no 163 0.0351221899338661 293 2788239 SGTC_558 k064-0027 21.3 µM 1.80362024932346 0.0317813723301656 no 164 0.0356454297207627 289 5088526 SGTC_196 k015-0023 18.111 µM 1.79283966934192 0.0325819145063515 no 165 0.0364992821970386 302 5211998 SGTC_230 MPP+ 141.667 µM 1.79131908406726 0.03269615681736 no 166 0.0366210526844829 275 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death. SGTC_2175 5807670 165.306 µM 1.78703570317417 0.0330197461189727 no 167 0.0369658591125959 267 241186 SGTC_169 k015-0017 16.025 µM 1.77861162510316 0.0336638450828486 no 168 0.0376517284373986 260 1840002 SGTC_1310 1188-0297 994 nM 1.77368727855421 0.0340451218732697 no 169 0.0380574459236196 313 1588352 SGTC_1244 0416-0015 52.5 µM 1.77262597438505 0.0341277587568138 no 170 0.0381453523696367 311 96201 SGTC_3262 9137218 49.47 µM 1.76674894761173 0.0345883548716934 no 171 0.0386351410052481 142 17650664 SGTC_958 1222-0007 33 µM 1.76475591863632 0.0347457078037918 no 172 0.0388023980548954 321 7312461 SGTC_2230 bromochlorosalicylanilide 954.5 nM 1.76107947281532 0.0350375113859666 no 173 0.0391124764050277 177 77254 SGTC_3069 9117009 49.47 µM 1.75968573569129 0.0351486582644614 no 174 0.0392305528409495 189 41904981 SGTC_3155 9099265 49.47 µM 1.75788799810443 0.0352924501700742 no 175 0.03938328417393 271 25236499 SGTC_299 1273-0059 1.44 µM 1.7575283941112 0.0353212709006431 no 176 0.0394138932275122 271 2848077 SGTC_2852 9023854 51.95 µM 1.75675126191241 0.0353836206781795 no 177 0.0394801078821525 307 19798528 SGTC_1256 0570-0116 285 µM 1.75018553346992 0.03591400342648 no 178 0.0400431521319488 282 410638 SGTC_1590 st077108 57.8 µM 1.74930733075882 0.0359854363649731 no 179 0.0401189547393082 249 5489485 SGTC_1702 st027038 51 µM 1.74891698085627 0.0360172247338757 no 180 0.040152685437085 317 5521182 SGTC_1929 genistein trimethyl ether 50.5 µM 1.74738983303052 0.0361418099676759 no 181 0.0402848699283639 307 136420 SGTC_268 camptothecin 39.6153 µM 1.74417131629079 0.0364055332829283 no 182 0.0405646106935762 434 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_1736 st036774 51 µM 1.74301409434668 0.0365007394334314 no 183 0.0406655764441034 324 1272247 SGTC_1339 1486-1321 22.7 µM 1.73696987002169 0.0370013217853141 no 184 0.0411962446308122 320 3469382 SGTC_2692 st077426 47.7 µM 1.73091947684825 0.03750802142519 no 185 0.0417330636407066 321 25238571 SGTC_892 0929-0076 29 µM 1.72815839376286 0.0377411282669451 no 186 0.0419799153869875 381 5751038 SGTC_1128 3448-9350 235 µM 1.72058903537631 0.0383862476090437 no 187 0.0426627122589548 316 619386 SGTC_2141 5621638 7.665 µM 1.71686168324456 0.0387072089930099 no 188 0.0430022236652837 295 2856238 SGTC_895 0964-0006 13.7 µM 1.71456014484506 0.0389064833791667 no 189 0.0432129505633526 302 6738897 SGTC_749 1000-0129 128 µM 1.70004913699452 0.0401822094228236 no 190 0.0445608416625547 346 708470 SGTC_1528 arabinosylhypoxanthine 74.6 µM 1.69953926639284 0.0402276450951628 no 191 0.0446088113017746 355 804 An inhibitor of viral and cellular DNA polymerases. SGTC_944 3370-0224 231 µM 1.69948319571773 0.0402326442202525 no 192 0.04461408907993 322 4580514 SGTC_1371 2421-0008 32.7 µM 1.69938516276439 0.0402413858124493 no 193 0.0446233178601275 361 2827552 SGTC_1796 st049173 110.4 µM 1.69895441644388 0.0402798137176693 no 194 0.0446638863570584 244 94134 SGTC_2447 5741742 33.78 µM 1.69116098065665 0.0409802469053125 no 195 0.0454030305340327 357 1776504 SGTC_1406 3909-7906 11.9 µM 1.68973464623315 0.0411095016309539 no 196 0.0455393659047414 333 X1406 SGTC_565 1418-0001 44.5 µM 1.68827332882804 0.0412422691647457 no 197 0.0456793862922135 380 2862145 SGTC_3030 9087619 49.47 µM 1.68613295118059 0.0414373597242431 no 198 0.0458850972703111 319 25236973 SGTC_2067 5224629 34.075 µM 1.68224653927858 0.0417935087372979 no 199 0.0462605215107376 351 2835000 SGTC_340 k038-0059 454 µM 1.68198777591043 0.0418173094437742 no 200 0.046285605165104 351 23733424 SGTC_1982 st072467 71.9 µM 1.67982947748415 0.0420162546692877 no 201 0.0464952490573447 401 3163533 SGTC_3244 9134489 49.47 µM 1.67882242445739 0.0421093434644234 no 202 0.0465933284488782 328 16584271 SGTC_2913 7966556 36.57 µM 1.67839735427725 0.0421486856707576 no 203 0.0466347768863913 295 2976516 SGTC_1781 st038725 66.3 µM 1.6732139847142 0.0426308274431081 no 204 0.0471425891344224 451 4270275 YIL048W NEO1 SGTC_2524 avocatin b 10.57 µM 1.66755995843551 0.0431618230733324 no 205 0.0477015562923573 295 6710748 SGTC_1176 0848-0131 83.3 µM 1.66659623830774 0.043252861098365 no 206 0.0477973586956461 360 6769040 SGTC_1113 artemisinin 1.17947 µM 1.65750878995841 0.0441189548925446 no 207 0.0487083266217796 345 2240 An anti-malaria and mitochondrial poison. SGTC_1758 st042942 75.2445 µM 1.64667135691977 0.0451700557839853 no 208 0.0498128073419419 318 669317 SGTC_2929 9013348 24.6 µM 1.64384972417961 0.0454470009867321 no 209 0.0501036236697967 361 2995952 SGTC_2788 5282734 71.43 µM 1.64147366740207 0.0456812702702937 no 210 0.0503495644360527 406 743706 SGTC_141 0443-0274 32.331 µM 1.63972274406701 0.0458545244731758 no 211 0.0505314138583018 488 1627241 SGTC_3150 9097574 49.47 µM 1.63360270930019 0.046464255242048 no 212 0.051171149289689 290 17217476 SGTC_425 3825-7017 13.1 µM 1.62929199412655 0.0468976193854666 no 213 0.0516256100734339 396 3397440 SGTC_11 0438-0307 1.3 µM 1.62632903695641 0.047197366396975 no 214 0.051939838949669 323 4011476 SGTC_1791 st048313 56.1 µM 1.62386498899023 0.0474478092449235 no 215 0.0522023130790379 306 1204976 SGTC_229 benomyl 22.8748 µM 1.60950692114362 0.0489283942938445 no 216 0.0537527714221766 396 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C SGTC_271 rotenone 740 µM 1.60720472143102 0.0491691919239974 no 217 0.0540047333346048 400 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria. SGTC_183 3914-0051 30.55 µM 1.60646250530134 0.0492470251528489 no 218 0.0540861634239952 354 1596232 SGTC_2515 chrysin 20.77 µM 1.6046374937129 0.0494388252058974 no 219 0.0542868025499448 330 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor. SGTC_1689 st020265 53.493 µM 1.60371149550143 0.0495363710014935 no 220 0.0543888304107994 341 5758320 YPR016C TIF6 SGTC_3090 9117696 49.47 µM 1.59550431530125 0.0504076542120663 no 221 0.0552997528907443 340 7923821 SGTC_1733 st037357 54.9 µM 1.59492262059862 0.0504698680748315 no 222 0.0553647702453753 417 1272339 YGL099W LSG1 SGTC_2985 9022375 71.43 µM 1.58953088607071 0.051049444805936 no 223 0.0559702933536746 382 4939335 SGTC_1521 st012942 49.4 µM 1.58566493446051 0.0514682610495786 no 224 0.0564076688100922 415 24207259 SGTC_2585 alliin 100 µM 1.58429771544574 0.0516170305643738 no 225 0.0565629927271582 412 87310 A garlic compound which reacts with lipids. SGTC_3314 9135860 59.4275 µM 1.57823083205017 0.0522813076990433 no 226 0.0572562947505427 377 25252478 SGTC_861 0443-0273 110 µM 1.57791792055115 0.0523157523492003 no 227 0.0572922337306795 358 6149169 SGTC_1050 3232-1156 69.3 µM 1.57640966684989 0.0524820306149396 no 228 0.0574657109973605 384 700529 SGTC_2291 7917025 104.35 µM 1.575083438349 0.0526285877904952 no 229 0.0576185931615266 417 2964612 SGTC_2967 9089538 49.85 µM 1.57394127344736 0.0527550648337763 no 230 0.0577505134341438 421 728216 SGTC_1988 st071872 53.4 µM 1.56862521476953 0.0533469121370848 no 231 0.0583676467907133 322 16414116 SGTC_1859 st055998 20 µM 1.56355694320234 0.053916061200758 no 232 0.0589608265642158 409 676301 SGTC_2659 sanguinarine 24.21 µM 1.5633872004399 0.0539352055947677 no 233 0.0589807744495169 381 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis. SGTC_2946 9065502 71.43 µM 1.55960690978556 0.0543629608803922 no 234 0.0594264013139318 238 16489101 SGTC_2761 levamisole 97.89 µM 1.55943498655144 0.0543824783143912 no 235 0.0594467304826741 368 26879 An alkaline phosphatase inhibitor. SGTC_2671 danthron 100 µM 1.55522582392442 0.0548620511603473 no 236 0.0599461480376475 384 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin. SGTC_604 1000-0114 314 µM 1.55409636936529 0.0549913032415344 no 237 0.0600807155580555 423 1572745 SGTC_1656 st012921 11 µM 1.5506043057178 0.0553924491745118 no 238 0.0604982698353491 354 6732821 SGTC_3063 1327-0034 4 µM 1.54874844659327 0.055606576739952 no 239 0.0607211014155204 376 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_2101 5377231 179.231 µM 1.5484496437213 0.0556411133631881 no 240 0.0607570383662907 356 2844213 SGTC_2999 9069765 71.4286 µM 1.54766726164592 0.0557316238707741 no 241 0.0608512140698792 399 2097066 SGTC_1135 dihydrocapsaicin 536.708 nM 1.54579169748151 0.0559490731574123 no 242 0.0610774414070213 414 107982 A Capsaicinoid. SGTC_3225 9130819 49.47 µM 1.54394957761952 0.0561632958962184 no 243 0.0613002741159654 407 4547121 SGTC_730 1436-0052 41.2 µM 1.54302676853752 0.0562708535597904 no 244 0.061412140595562 340 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2 SGTC_1878 temozolomide 1 mM 1.5426655704133 0.0563129970642713 no 245 0.0614559698257765 345 5394 DNA alkylating agent. SGTC_3344 9148862 3.898 µM 1.54179451007327 0.0564147321037238 no 246 0.0615617682910125 373 4905352 SGTC_564 3555-0129 330 µM 1.54178111424922 0.0564162977922869 no 247 0.0615633964495724 302 563260 SGTC_2176 5809774 33.9695 µM 1.54110051828934 0.0564958901496393 no 248 0.0616461618764384 398 2870539 SGTC_1469 k284-2957 126 µM 1.54076702766698 0.0565349225306493 no 249 0.0616867484687284 356 23884841 SGTC_2201 6605497 169.863 µM 1.53987115436041 0.0566398824782469 no 250 0.0617958816590334 358 670741 SGTC_2205 7238770 200 µM 1.53983341310096 0.0566443075879589 no 251 0.0618004825172274 342 279867 SGTC_1622 st003707 19.4 µM 1.53719899039101 0.056953863562614 no 252 0.062122293757124 455 10140899 SGTC_357 1325-0123 420 µM 1.53545963137647 0.0571589747157156 no 253 0.0623354828867871 364 1098503 SGTC_4 0960-0234 25.671 µM 1.53347407423094 0.057393828592689 no 254 0.0625795448790623 374 6821112 SGTC_404 fumagillin 50 µM 1.53050922305464 0.057745926872033 no 255 0.0629453661455069 431 12015870 A methionine aminopeptidase binder. SGTC_2303 7774051 200 µM 1.52157533451383 0.0588171686518525 no 256 0.0640577608851481 382 2953184 SGTC_1567 st069303 68.4 µM 1.51814789150683 0.0592322609480237 no 257 0.0644885601461145 442 5581319 SGTC_2249 haloperidol 116.36 µM 1.51623102104304 0.0594654098058041 no 258 0.0647304733285187 554 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_2960 9079389 5.97 µM 1.515388860416 0.0595680689379669 no 259 0.0648369783763437 416 16457355 SGTC_2375 9072683 200 µM 1.51486524646211 0.0596319673173752 no 260 0.0649032665278657 447 16798029 SGTC_3139 9095020 49.47 µM 1.51096998056493 0.0601090072199132 no 261 0.0653980497102789 289 25236292 SGTC_2011 4012611 177 µM 1.50631717858836 0.0606827301589166 no 262 0.0659928851440508 438 2049887 SGTC_2543 pimpinellin 60.67 µM 1.50507033008922 0.0608372006799303 no 263 0.0661529980380593 396 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo. SGTC_1120 ficusin 1.78878 µM 1.50230232964764 0.0611812236965589 no 264 0.0665095236415537 404 6199 A DNA cross-linker. SGTC_1545 lovastatin 49.4 µM 1.5016070250264 0.0612678786083311 no 265 0.066599314001492 468 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12 SGTC_274 sirtinol 40.1 µM 1.50055236588536 0.0613995024212099 no 266 0.0667356898005584 416 6836442 NAD-dependent acetyltransferase inhibitor. SGTC_1207 2099-0101 141 µM 1.49853861203705 0.0616514368239044 no 267 0.0669966842619944 462 5837381 SGTC_1295 1013-0063 9.78 µM 1.49540642501818 0.0620448980641169 no 268 0.0674042023751081 430 6826038 SGTC_1522 st012842 45.6 µM 1.49187865926481 0.0624903944957478 no 269 0.0678654790852049 394 3491067 YOR116C RPO31 SGTC_2888 9058547 12.99 µM 1.49168720244559 0.062514643377117 no 270 0.0678905827943109 337 16476514 SGTC_902 1120-0002 2.07 µM 1.49128239791731 0.0625659378730195 no 271 0.0679436841428929 471 3280475 SGTC_413 propylparaben 100 µM 1.48887401381587 0.0628717929810613 no 272 0.0682602738183396 383 7175 A pharmaceutical preservative. SGTC_556 4058-0063 51.5 µM 1.48800138042873 0.062982900986309 no 273 0.0683752647922898 455 6615692 SGTC_2915 7971052 15.16 µM 1.48711919642991 0.0630953804342349 no 274 0.0684916661675242 293 5741558 SGTC_3117 9124945 49.47 µM 1.48375417158674 0.0635258618549368 no 275 0.0689370745567062 357 17592065 SGTC_109 0132-0036 33.701 µM 1.47778584698029 0.0642949965526645 no 276 0.069732553882376 295 67274 A color developer. SGTC_70 0141-0289 43.283 µM 1.47577746853702 0.0645554363166489 no 277 0.0700018206430902 681 352408 SGTC_316 k060-0003 58.6 µM 1.46731269232865 0.0656621347442543 no 278 0.0711455062800281 423 6152314 SGTC_3027 9089541 49.47 µM 1.46626441652221 0.0658002054691178 no 279 0.0712881327610507 460 9943819 SGTC_110 0850-0284 111.64 µM 1.46234747816101 0.0663181061484549 no 280 0.0718230071016067 304 3906265 SGTC_563 tetrahydrosecaminediol 614 µM 1.4584783143803 0.0668327836295834 no 281 0.0723543741088666 463 334274 A psychoactive constituent of the cannabis plant. SGTC_1309 pyrazolanthrone 13.4 µM 1.45787092474342 0.0669138586937299 no 282 0.072438062089327 460 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14 SGTC_1461 k072-0203 53.8 µM 1.45521292474974 0.0672695468365901 no 283 0.0728051619256215 419 5418714 SGTC_2717 st081029 62.2815 µM 1.45397472369646 0.0674357386305912 no 284 0.072976657040767 397 5292846 SGTC_3106 9121286 49.47 µM 1.45339461310863 0.0675137103646687 no 285 0.0730571106454443 386 15943471 SGTC_3343 9148379 18.9835 µM 1.45090401465293 0.0678492595582097 no 286 0.073403294928305 427 1955036 SGTC_2789 5281112 71.43 µM 1.44767050188252 0.0682868186694522 no 287 0.073854611731043 459 765948 SGTC_679 0422-0091 41.4 µM 1.44649449523217 0.0684464948597151 no 288 0.0740192774436337 493 627384 YHR062C RPP1 SGTC_1712 st032288 53.4 µM 1.44569336195786 0.0685554362296202 no 289 0.0741316135120099 639 2883011 SGTC_1812 st052057 4.327 µM 1.44170370587858 0.0690999585193349 no 290 0.0746929888693691 467 3645418 SGTC_1071 trifluoperazine 6.31 µM 1.44071563749029 0.0692353271266698 no 291 0.0748325176323155 480 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. SGTC_1798 st045719 60.953 µM 1.4293162639106 0.0708118902229473 no 292 0.0764566767526045 401 3980186 SGTC_964 1287-0107 19.4 µM 1.42825543959057 0.070959996567007 no 293 0.0766091743064909 503 51516812 YPR165W RHO1 SGTC_645 0845-0943 5.41 µM 1.42170520882201 0.0718797787461021 no 294 0.077555923681682 464 1885106 SGTC_98 0074-0023 107.663 µM 1.42134161941847 0.0719311004882246 no 295 0.0776087348285141 500 3563821 SGTC_214 4373-3496 70 µM 1.42014732198124 0.0720998769194159 no 296 0.0777823979735293 647 3779166 SGTC_381 3461-2219 42.7 µM 1.4134173936102 0.073056621255221 no 297 0.0787665171680341 484 2883159 SGTC_2186 6124449 200 µM 1.41286301062321 0.0731358649017712 no 298 0.0788480034449204 447 3834182 YLR033W RSC58 SGTC_105 0111-0055 734.78 µM 1.41038286553212 0.0734911829770268 no 299 0.0792133310150353 389 5179370 SGTC_1709 st033179 39.1045 µM 1.40998197593141 0.073548740165919 no 300 0.0792725025337304 493 573381 SGTC_1693 xanthone 101.9 µM 1.4080607466434 0.0738250566094368 no 301 0.079556541528532 498 7020 An insecticide. SGTC_2354 9060492 162 µM 1.40221897107143 0.0746701112017228 no 302 0.080424934120049 529 6471895 SGTC_1424 4048-1941 275 µM 1.4011020631996 0.0748325172344251 no 303 0.0805917773671874 498 X1424 SGTC_2795 7780010 54.55 µM 1.39604588979328 0.0755710923555624 no 304 0.0813503383036255 447 953673 SGTC_1589 2',5'-dimethoxyflavone 47.2 µM 1.39284825322098 0.0760410426661828 no 305 0.0818328416210818 524 688667 SGTC_1367 1812-0510 76.9 µM 1.38638720553255 0.0769973952209382 no 306 0.0828143505725017 477 1142582 YDR527W RBA50 SGTC_2547 epiafzelechin trimethyl ether 100 µM 1.38241245072432 0.0775902566239923 no 307 0.0834225476498434 305 6708630 An antioxidant. SGTC_1497 4476-2978 41.3 µM 1.38067591167512 0.0778503584039517 no 308 0.0836893154927383 539 1528379 SGTC_2565 isoliquiritigenin 100 µM 1.37890544391736 0.0781162227868632 no 309 0.0839619547414825 398 638278 Binds to benzodiazepine receptor 65X better than valium. SGTC_3346 9158254 43.5805 µM 1.37719909565642 0.0783731098242434 no 310 0.0842253506860834 506 17639500 SGTC_3126 9127922 49.47 µM 1.37696018121625 0.0784091289386947 no 311 0.0842622795254539 516 45595682 SGTC_3255 9139072 49.47 µM 1.37628947888899 0.0785103121429 no 312 0.084366014459567 495 17646060 SGTC_1817 st052116 64.4 µM 1.37446689724511 0.0787857695929638 no 313 0.084648390107883 473 4361398 SGTC_2257 7960413 200 µM 1.37261144153407 0.0790669470692036 no 314 0.0849365865332698 562 2974689 YIL048W NEO1 SGTC_1667 st014849 34.6 µM 1.37224079824212 0.079123205652942 no 315 0.084994244294677 506 5348460 SGTC_2862 9027634 71.43 µM 1.35781934122834 0.0813357960283132 no 316 0.0872605080895696 486 5012562 SGTC_1086 cerivastatin 2.18 µM 1.35700160419868 0.081462640459426 no 317 0.0873903503977077 475 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7 SGTC_360 0957-0399 1.01 µM 1.35294242231051 0.082094495302467 no 318 0.0880370126837923 543 6752301 YPR165W RHO1 SGTC_633 0437-0093 97.7 µM 1.35262606500055 0.0821438943400827 no 319 0.0880875605719766 482 2831118 SGTC_107 0358-0022 2.6945 µM 1.35130723218878 0.0823500706939951 no 320 0.088298518138819 358 521106 YGL093W | YPR107C SPC105 | YTH1 SGTC_2068 5226020 147 µM 1.34955740946595 0.0826242259427886 no 321 0.0885789967882226 566 1810509 SGTC_1062 mesoridazine 14.2 µM 1.34777790553671 0.0829037354766986 no 322 0.0888649131316844 532 4078 A neuroleptic. SGTC_3252 9135871 49.47 µM 1.34491834925043 0.0833543796330066 no 323 0.0893258019554564 508 17682838 SGTC_2829 7992743 58.44 µM 1.34069250740731 0.0840237076504492 no 324 0.0900101541079462 517 16462845 SGTC_1500 4488-1866 171 µM 1.33485724616042 0.0849545730252532 no 325 0.0909615365155205 567 2900003 SGTC_2216 7189485 200 µM 1.33270775475565 0.0852994102559146 no 326 0.0913138637103837 503 731273 SGTC_2087 5276107 200 µM 1.33107730990268 0.0855616768000654 no 327 0.0915817870427117 507 144405 SGTC_416 estradiol valerate 100 µM 1.33095703356001 0.0855810478386933 no 328 0.0916015745355328 502 13791 A steroid. SGTC_221 trifluoperazine 10.304 µM 1.3283520291196 0.0860014015419297 no 329 0.0920309195204219 700 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1 SGTC_2182 6325192 200 µM 1.32824527379686 0.0860186608926381 no 330 0.0920485461768501 496 736248 SGTC_3095 9117207 49.47 µM 1.32645042184887 0.0863092264674185 no 331 0.092345273386821 450 17015229 SGTC_1891 st059073 26.2 µM 1.31840011215195 0.0876215115223098 no 332 0.0936848716397417 584 688754 SGTC_3170 9103054 49.47 µM 1.316733753875 0.0878949955362321 no 333 0.0939639426013767 481 16432970 SGTC_1028 k015-0029 4.8 µM 1.31373638412629 0.0883885277970174 no 334 0.0944674661743547 568 4588309 SGTC_2619 obliquin 87.91 µM 1.30669109181753 0.089556697601532 no 335 0.0956588226644104 649 6708593 A bioactive alkalod. YER133W GLC7 SGTC_838 0109-0203 71.4 µM 1.30361900161634 0.090069656066054 no 336 0.0961817593264426 550 759422 SGTC_2597 laccaic acid a 100 µM 1.30209106633249 0.0903255925750339 no 337 0.0964426283693763 560 5491415 A textile dye. SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM 1.29809803172663 0.0909969945433006 no 338 0.0971268252961363 604 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_2759 disulfiram 3.38 µM 1.29330827945577 0.0918072342897659 no 339 0.0979522291225073 528 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_835 0312-0010 67.2 µM 1.29146690752914 0.0921201408117277 no 340 0.0982709114922663 514 1626196 SGTC_1016 4226-1401 38 µM 1.290045758304 0.092362177704783 no 341 0.0985173855398045 568 2901613 SGTC_1826 st055655 41.6 µM 1.28926796695983 0.09249484297879 no 342 0.0986524716414233 574 676168 SGTC_2053 5265679 138 µM 1.28870129304115 0.0925915873968578 no 343 0.0987509763969448 587 764595 SGTC_2292 7671323 168.05 µM 1.28789743838589 0.0927289524578172 no 344 0.0988908336571452 562 937504 SGTC_1633 st005664 67.9 µM 1.28747471940162 0.0928012483662346 no 345 0.0989644378042955 573 2063822 SGTC_1654 st012436 41.8 µM 1.2860555343229 0.0930442706744516 no 346 0.0992118405043471 507 4323132 SGTC_295 k015-0027 31 µM 1.2800295292587 0.0940814085849123 no 347 0.100267375408315 547 3887424 SGTC_149 3970-0822 46.1 µM 1.28000887284187 0.0940849783782205 no 348 0.10027100769686 711 3114250 YBL034C STU1 SGTC_2374 9071832 200 µM 1.27980215909943 0.0941207076646448 no 349 0.100307362173582 521 17381698 SGTC_2690 usnic acid 100 µM 1.27853965237657 0.0943391420119727 no 350 0.10052960639911 637 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_22 0964-0034 14.468 µM 1.27785177770771 0.0944583128271168 no 351 0.100650846876568 587 138402 SGTC_671 0560-0003 407 µM 1.27353685855913 0.0952083835952597 no 352 0.101413800938954 539 3238678 SGTC_591 4299-0174 154 µM 1.26961779848114 0.0958934340045889 no 353 0.102110403154471 565 5509088 SGTC_1686 st019653 115.5 µM 1.26951510889895 0.0959114327237588 no 354 0.102128702634568 558 97252 SGTC_2252 omeprazole 400 µM 1.26945050000327 0.0959227581970935 no 355 0.102140217286171 464 4594 A proton pump inhibitor. SGTC_2096 5468907 200 µM 1.26817991120544 0.0961456831489636 no 356 0.102366854641676 554 759785 SGTC_2353 9059630 146.67 µM 1.26805509421479 0.0961676028329117 no 357 0.102389138198771 540 4779114 SGTC_3029 9088683 49.47 µM 1.2680478666592 0.0961688722095979 no 358 0.102390428641132 551 25236615 SGTC_3018 9082602 49.47 µM 1.26730596439107 0.0962992381518613 no 359 0.102522954345258 594 17332089 SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM 1.26446701608205 0.0967992933304443 no 360 0.103031226130526 558 2724278 An inhibitor of dopamine biosynthesis. SGTC_1087 pterostilbene 9.05 µM 1.26443632183155 0.0968047102459998 no 361 0.103036731466572 605 5281727 Similar to reservatol, lowers cholesterol. SGTC_72 0744-0168 198.391 µM 1.26379880647475 0.096917269165392 no 362 0.103151124849389 563 677577 SGTC_663 1486-0733 13.9 µM 1.26133257099046 0.0973536095052668 no 363 0.103594525484588 647 722445 YPR165W RHO1 SGTC_1000 4048-0884 8.67 µM 1.2606996589803 0.097465819909395 no 364 0.103708538437448 580 13040088 SGTC_2924 9010168 62.78 µM 1.26001047438186 0.0975881148663015 no 365 0.103832791857327 595 2993929 SGTC_1452 4194-0072 190 µM 1.25758331729622 0.0980197068592636 no 366 0.104271244902551 645 1343545 SGTC_1303 1160-0052 261 µM 1.25704106413313 0.0981163200367138 no 367 0.104369383180577 578 3562476 SGTC_1359 1582-0056 520 nM 1.25511762458132 0.0984595816539728 no 368 0.104718031659798 635 3661189 SGTC_1115 galangin 695.678 nM 1.25357424117411 0.0987356527635952 no 369 0.104998399362954 635 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_285 1486-1325 46 µM 1.2535054930757 0.0987479631744638 no 370 0.105010900623019 612 22310230 SGTC_182 3448-4371 550.524 µM 1.25323789305964 0.0987958917940284 no 371 0.105059571680748 615 3491403 SGTC_1040 k898-0338 155 µM 1.25107705609855 0.0991835332961965 no 372 0.105453182760406 621 20969351 SGTC_1273 0849-0096 14.1 µM 1.25046685054101 0.0992932017303956 no 373 0.105564528720948 569 5286025 SGTC_2460 5552655 174.22 µM 1.24799365620313 0.0997386014098697 no 374 0.106016690188431 571 5401989 SGTC_1426 4048-4480 71.7 µM 1.24215925129312 0.100795103925875 no 375 0.107088905436496 603 14224343 SGTC_2129 girgensonine 121.053 µM 1.24145823333105 0.10092259241363 no 376 0.107218259136376 650 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_1764 st044502 93.5 µM 1.23328106561516 0.102418399626209 no 377 0.108735459798689 594 8407 SGTC_2309 7664088 163.95 µM 1.23087757712137 0.102861107720238 no 378 0.109184327577207 660 704922 SGTC_1552 6-methylflavone 10.6 µM 1.22941656627195 0.103130895687422 no 379 0.109457831083315 539 689013 SGTC_3149 9097855 49.47 µM 1.22557913088781 0.103841957193131 no 380 0.110178547577017 579 25236625 YMR079W SEC14 SGTC_729 4092-0585 94.1 µM 1.22297111073541 0.104327238353933 no 381 0.110670303977355 563 2169061 SGTC_2278 7948257 134.34 µM 1.22266801432733 0.104383742726835 no 382 0.110727556319982 598 1247028 SGTC_1551 6-bromo-3'-methylflavone 63.5 µM 1.2214907714939 0.104603419107006 no 383 0.110950128816493 637 688751 SGTC_1360 1598-0022 39.8 µM 1.21874641547814 0.105116822465503 no 384 0.111470227543328 703 761525 SGTC_2112 5488546 200 µM 1.21860807830272 0.105142750236532 no 385 0.111496490733783 613 600757 SGTC_303 1348-1668 34.2 µM 1.21747405559678 0.105355468323983 no 386 0.111711950884999 576 5380509 SGTC_1460 k062-0059 9.15 µM 1.21267522006071 0.106259072124604 no 387 0.112627008752994 595 1373085 SGTC_1343 1487-0095 224 µM 1.2098597091204 0.106791821380153 no 388 0.113166364958425 588 4560101 YGL055W OLE1 SGTC_1225 1216-0074 20.6 µM 1.20578308175814 0.107566609891916 no 389 0.113950570237421 609 4241466 SGTC_20 0481-0013 4.944 µM 1.20250662440269 0.108192250876898 no 390 0.114583650554668 603 182045 SGTC_3181 9108277 49.47 µM 1.19651840632208 0.109342463720587 no 391 0.115747160056943 593 17097298 SGTC_547 1120-0019 610 nM 1.19650940436471 0.109344199397421 no 392 0.115748915428844 620 3676939 SGTC_657 3534-0529 86.7 µM 1.19600671174191 0.109441155502556 no 393 0.115846969953309 610 1049549 SGTC_2402 5553605 200 µM 1.19509825425163 0.109616529506929 no 394 0.116024321997487 640 6758546 SGTC_2564 betulinic acid 100 µM 1.19404803807246 0.109819520802165 no 395 0.116229588735119 681 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14 SGTC_687 k029-0044 34.9 µM 1.19252554409769 0.110114275288648 no 396 0.116527620438183 661 5829338 SGTC_575 k072-0246 11.9 µM 1.19138194594812 0.110336048569598 no 397 0.116751838589324 635 6796779 SGTC_576 1073-0113 22.7 µM 1.19126420056327 0.110358900620781 no 398 0.116774941547576 803 5439563 SGTC_1999 st074831 12.5 µM 1.18649589717107 0.111287187332567 no 399 0.117713260392124 658 17112523 SGTC_2902 5787006 60.46 µM 1.18501753933697 0.111576123964746 no 400 0.118005256124058 611 591003 SGTC_1466 k213-0079 57.5 µM 1.18342313940693 0.111888341540665 no 401 0.118320745601163 643 3657981 SGTC_2075 5212009 200 µM 1.18148693370136 0.112268331397527 no 402 0.118704670549839 561 780898 SGTC_3248 9135562 49.47 µM 1.18077181503199 0.112408909889668 no 403 0.118846691797211 681 17650701 SGTC_635 k038-0028 24.7 µM 1.17895926821081 0.112765784754585 no 404 0.119207197721846 653 4035102 SGTC_2983 9022671 12.99 µM 1.17289176008901 0.113966309439582 no 405 0.1204196071514 613 6405161 SGTC_535 2293-4129 48.2 µM 1.17005949187225 0.114529812228847 no 406 0.120988514267246 727 396118 YIL048W NEO1 SGTC_2062 5245942 200 µM 1.16986263414731 0.114569052254476 no 407 0.121028126512034 676 1376160 SGTC_2721 ifenprodil 61.44 µM 1.1684905855926 0.114842811077961 no 408 0.121304467266114 641 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor. SGTC_270 tamoxifen 5.46 µM 1.16848442514872 0.114844041292739 no 409 0.121305709024931 709 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  YIL048W NEO1 SGTC_2840 9008771 71.43 µM 1.16727224982873 0.115086290046226 no 410 0.121550220781801 597 2992978 SGTC_1962 st076595 64.5 µM 1.1666943326097 0.115201912486937 no 411 0.121666916180442 648 279619 SGTC_1933 st074711 15.9 µM 1.16588198290042 0.115364576833146 no 412 0.12183108222249 688 17250958 SGTC_1252 0493-0875 34.8 µM 1.1640891673537 0.115724146482778 no 413 0.122193939076059 629 3960963 SGTC_2654 protoveratrine a 100 µM 1.16399553081068 0.115742948210049 no 414 0.122212911468552 638 5702278 A heart drug and vasodilator. SGTC_2518 prenyletin 46.28 µM 1.16270654948511 0.116001989426412 no 415 0.122474291703294 551 3873459 A coumarin with calcium channel inhibitory activity. SGTC_2295 7971645 200 µM 1.16070932655559 0.116404175467961 no 416 0.122880063862419 654 2978226 YKL099C UTP11 SGTC_502 l-744,832 89.3 µM 1.15576792346555 0.117403487345602 no 417 0.123888048344949 671 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.  SGTC_2859 9028643 45.46 µM 1.15564968533561 0.117427473120816 no 418 0.123912238136029 611 17151580 SGTC_2604 4'-hydroxychalcone 11.32 µM 1.15539612043694 0.117478922970155 no 419 0.123964124949332 605 5282362 SGTC_2211 7117706 200 µM 1.15425945568127 0.117709755249572 no 420 0.124196906735596 629 822771 SGTC_1156 4092-0367 4.88 µM 1.15394762212332 0.117773138044363 no 421 0.1242608217024 671 1357585 SGTC_2640 pentamidine 10.38 µM 1.15299762541129 0.117966381728044 no 422 0.124455679579197 718 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_1231 0242-0792 125 µM 1.15243961784218 0.118079993414063 no 423 0.124570234445252 640 3707635 SGTC_1559 coumarin 343 70.1 µM 1.15038082457961 0.118499838114569 no 424 0.124993527216754 619 108770 A hepatotoxic, DNA x-linker. SGTC_1568 digitonin 820 nM 1.14987668734504 0.11860280620131 no 425 0.125097331985815 709 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1 SGTC_1124 fisetin 1.16336 µM 1.14931237286668 0.118718140232444 no 426 0.125213598996365 612 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster. SGTC_396 dithiazanine 1.25 µM 1.14927676751683 0.118725419874832 no 427 0.125220937378241 630 10578 An antihelmenthic. SGTC_90 0870-0863 4.608 µM 1.1480377227881 0.118978943499453 no 428 0.125476495722147 703 1738164 SGTC_212 3807-4682 38.772 µM 1.147267041733 0.11913682692539 no 429 0.125635635526803 822 3125501 YBL034C STU1 SGTC_2968 9090663 33.37 µM 1.14638463459319 0.119317780353046 no 430 0.125818018784546 668 25236811 SGTC_1749 st037932 54.2 µM 1.14604320527166 0.119387848583476 no 431 0.12588863776731 623 594497 SGTC_2998 9066762 71.4286 µM 1.14347541458395 0.119915741733784 no 432 0.126420628339026 710 4945196 SGTC_846 0335-0850 148 µM 1.13811703745709 0.121022625280216 no 433 0.127535807380278 650 6819598 SGTC_1001 4048-4355 44.4 µM 1.13759416432413 0.121131019225078 no 434 0.127644992266041 667 21824233 SGTC_139 0099-0334 718.624 µM 1.13693716149327 0.121267315647415 no 435 0.127782277835542 779 97690 SGTC_419 nsc-638432 893 µM 1.12852364496718 0.123022253299416 no 436 0.12954941840253 673 368090 SGTC_769 0302-0231 76 µM 1.12751624577431 0.12323356964565 no 437 0.129762137863267 783 571869 YER009W NTF2 SGTC_2532 xanthone 78.9 µM 1.1261849623929 0.123513215306633 no 438 0.130043618609764 618 7020 An insecticide. SGTC_24 0417-1663 219 µM 1.12307768567041 0.124167649659534 no 439 0.130702251122696 668 4329390 SGTC_1560 lithocholic acid 53.1 µM 1.12260449355166 0.124267522737762 no 440 0.130802753048517 601 9903 A bile acid which acts as a detergent. SGTC_147 4466-0538 29.23 µM 1.12062336879556 0.124686273759799 no 441 0.131224106749045 705 6742687 YHR072W ERG7 SGTC_1029 k015-0030 64.7 µM 1.11977762431861 0.124865339105429 no 442 0.131404268339952 673 2208316 SGTC_16 erodoxin 22.806 µM 1.11966519652701 0.124889156415678 no 443 0.131428230708233 737 3967339 Erodoxin inhibits Ero1. YML130C ERO1 SGTC_1015 4130-4525 82 µM 1.11668847077026 0.125520916871466 no 444 0.132063774552274 697 1363237 SGTC_1604 st002052 72.4 µM 1.1131183869567 0.126281544755717 no 445 0.132828793896202 688 6254834 YHR062C RPP1 SGTC_1849 st056239 19.2 µM 1.11175059548153 0.126573810331577 no 446 0.133122699574226 694 5393181 SGTC_1945 st075991 56.6 µM 1.11083140300276 0.126770485125946 no 447 0.133320463332184 636 1084980 SGTC_2628 lathosterol 100 µM 1.11073410839808 0.126791315188877 no 448 0.133341408036538 700 6710616 SGTC_2081 5214970 32.255 µM 1.10912844602853 0.127135419961512 no 449 0.133687387498008 684 2063512 SGTC_994 3910-0338 138 µM 1.1062856188225 0.127746250479178 no 450 0.134301457197908 725 3479481 SGTC_3204 9114183 49.47 µM 1.10279471259405 0.128499118388175 no 451 0.135058162390233 670 17027248 SGTC_3260 9137109 49.47 µM 1.10133298718945 0.128815275025167 no 452 0.135375879667522 588 17478346 SGTC_2083 5306046 65.942 µM 1.09651579742403 0.129861002731152 no 453 0.136426556941808 704 539837 SGTC_8 0354-0001 70 µM 1.09628574649878 0.129911089396745 no 454 0.136476872525266 807 4993152 SGTC_2248 tofa 1.1 µM 1.09625974119846 0.129916752109512 no 455 0.136482561072396 675 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_2988 9073640 71.4286 µM 1.09614972437769 0.129940710410889 no 456 0.136506628571104 662 9102229 SGTC_1815 st051655 58.2 µM 1.09545264546716 0.13009258397952 no 457 0.136659190403364 680 5984156 SGTC_1592 4',5'-dihydroxyflavone 8.85 µM 1.09261623744286 0.130711822906252 no 458 0.137281165219707 724 688669 SGTC_2069 5228469 200 µM 1.09212664738687 0.13081891509953 no 459 0.13738871912916 670 2835210 SGTC_2103 5378138 10 µM 1.09159373671157 0.130935552091823 no 460 0.137505855164094 799 244142 SGTC_3107 9121808 49.47 µM 1.09053919354377 0.13116656939004 no 461 0.137737849137768 658 662681 SGTC_2226 7298446 200 µM 1.08746848432014 0.131840868227458 no 462 0.138414909676254 669 3283010 SGTC_3282 9108498 15.4605 µM 1.0873574739608 0.131865289764182 no 463 0.138439428753992 683 16459645 SGTC_2024 5144227 134 µM 1.0872442307213 0.131890205734829 no 464 0.138464444062113 760 3475211 SGTC_2608 thymoquinone 42.66 µM 1.08587617643215 0.13219146397272 no 465 0.138766889147574 667 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC). SGTC_42 0133-0086 60.653 µM 1.08470723113083 0.132449252155275 no 466 0.139025672078344 640 162923 Model of phenazepam hydroxylation. SGTC_1728 st035614 33.7865 µM 1.08346650208007 0.132723249604087 no 467 0.139300705807286 781 15945546 SGTC_353 1988-1175 58.3 µM 1.08228949142686 0.132983536348916 no 468 0.139561956970879 668 2788357 SGTC_2318 6029776 164 µM 1.08186432085143 0.133077645850879 no 469 0.139656410380688 716 818325 SGTC_1499 4480-0877 67.3 µM 1.08095774160234 0.133278465944183 no 470 0.139857955850566 683 2861909 SGTC_2596 sinensetin 100 µM 1.08003429247186 0.133483237219186 no 471 0.14006345489132 678 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets. SGTC_143 4032-1194 15.74 µM 1.07635443236143 0.134301380562913 no 472 0.140884386689106 815 1806963 SGTC_3125 9127534 49.47 µM 1.07407295183846 0.134810348085788 no 473 0.141394993131587 613 1639235 SGTC_292 k038-0015 474 µM 1.07104544642571 0.135487784624319 no 474 0.142074497844686 700 46368540 SGTC_1229 0139-0193 12.2 µM 1.06855360180605 0.136047108661066 no 475 0.142635432555969 787 3090752 SGTC_3327 9140648 26.9345 µM 1.06772386738899 0.136233702663786 no 476 0.142822544480141 711 8029710 SGTC_2041 5107442 45.335 µM 1.06359257965957 0.137165369382159 no 477 0.143756652677776 743 793005 SGTC_2742 clothiapine 36.27 µM 1.06279218924219 0.137346371414499 no 478 0.143938101215982 689 16351 An atypical antipsychotic. YIL048W NEO1 SGTC_1935 st074532 41.6 µM 1.05458658298739 0.139211412904371 no 479 0.145807221358079 836 2829742 SGTC_2645 abamectin 100 µM 1.05137497634602 0.139946046035883 no 480 0.146543202027939 720 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels. SGTC_59 0330-0160 1.33 µM 1.05104301284378 0.140022130381818 no 481 0.146619417639817 876 4293482 SGTC_2147 5545932 89.7195 µM 1.049848522318 0.140296134027998 no 482 0.146893881158961 730 797404 SGTC_1314 1222-0010 41.1 µM 1.04843279579865 0.140621358168656 no 483 0.147219625073195 753 3526027 SGTC_3080 9117754 49.47 µM 1.04796845457871 0.140728139114214 no 484 0.147326570520066 818 9550191 SGTC_1230 0170-0365 3.77 µM 1.04552137547604 0.141291783829409 no 485 0.147891033285643 891 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1 SGTC_2048 5246248 200 µM 1.04494329600624 0.141425158142728 no 486 0.148024588836218 745 677046 SGTC_682 0kpi-0099 17 µM 1.04438719452127 0.141553542197054 no 487 0.148153142898647 775 1714895 YML126C ERG13 SGTC_3162 9099653 49.47 µM 1.04362383563958 0.141729903170106 no 488 0.148329730307488 698 25237511 SGTC_223 busulfan 5 mM 1.04150392638106 0.142220452105291 no 489 0.148820865938674 682 2478 A DNA alkylator. SGTC_2038 4100038 30.985 µM 1.03876894277465 0.142855025285181 no 490 0.149456104307153 765 3596803 SGTC_2916 7875993 68.79 µM 1.03696332322136 0.143275013844268 no 491 0.149876475232435 765 1299250 SGTC_3023 9089636 49.47 µM 1.0362809770369 0.143433945006071 no 492 0.150035539108543 807 17249241 SGTC_2899 9053889 58.44 µM 1.03581791512499 0.143541868539621 no 493 0.150143549020931 753 6470052 SGTC_493 zm226600 134 µM 1.03467863446867 0.143807628287854 no 494 0.150409508593507 772 5240098 A potassium channel opener. YCR052W RSC6 SGTC_131 0141-0277 33.849 µM 1.03461135011727 0.143823334068681 no 495 0.150425225610752 758 1547771 SGTC_84 0443-0269 128.823 µM 1.03322489279522 0.144147224059638 no 496 0.150749333099087 796 6150058 SGTC_2165 5727197 32.143 µM 1.03280786864829 0.144244741112963 no 497 0.150846910329603 723 1361712 SGTC_718 1130-0073 349 µM 1.0319916064062 0.144435744813554 no 498 0.151038024793896 786 6740020 SGTC_942 3253-1115 227 µM 1.03051572010264 0.14478153170713 no 499 0.151383988331085 783 46497897 SGTC_491 tetrandrine 80.3 µM 1.02876785140069 0.145191762139041 no 500 0.151794388543347 737 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_3230 9131665 49.47 µM 1.02844349999501 0.145267974418604 no 501 0.151870627621088 647 15943720 SGTC_369 0957-0393 4.5 µM 1.02630093051839 0.145772086265414 no 502 0.152374879408157 720 6997992 SGTC_1641 st009299 47.1 µM 1.02569142413282 0.145915707810513 no 503 0.152518528981496 715 4046054 SGTC_2933 9026794 32.47 µM 1.02478791317721 0.146128782264619 no 504 0.152731635369484 788 17586027 SGTC_2464 5717415 7.67 µM 1.02455634464942 0.146183426564419 no 505 0.152786286004111 750 5285744 SGTC_2167 5876490 200 µM 1.02178558859545 0.146838319230963 no 506 0.153441195841903 794 686534 SGTC_3186 9110464 49.47 µM 1.01826587800207 0.147673067777609 no 507 0.154275809795399 764 17018021 SGTC_937 3122-0005 46.7 µM 1.01752633916069 0.147848863004609 no 508 0.154451554434686 832 759535 SGTC_2208 7283366 200 µM 1.01716655065587 0.147934438705782 no 509 0.154537102718944 803 898663 SGTC_590 k048-0076 22.4 µM 1.01538464392532 0.148358753936499 no 510 0.154961255063211 775 6832814 SGTC_114 0364-0001 490.298 µM 1.01506282458037 0.148435473632263 no 511 0.155037940529235 782 4003655 SGTC_217 ketoconazole 989 nM 1.01266586226824 0.149007728950505 no 512 0.15560989450799 780 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4 SGTC_1026 k007-1105 30.6 µM 1.01144643219068 0.149299422878013 no 513 0.155901403695917 839 7066794 SGTC_2773 thioridazine 9.09 µM 1.01025635753997 0.14958446219105 no 514 0.156186242241397 812 5452 An antipsychotic. SGTC_1524 corynanthine 62.1 µM 1.00967953296859 0.149722750220257 no 515 0.156324425674292 779 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist. SGTC_266 formosanin C 406 nM 1.00669087531986 0.150440616968346 no 516 0.157041674192303 792 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1 SGTC_308 4092-1169 104 µM 1.00655480334822 0.150473355540987 no 517 0.157074381569194 836 2268590 YDL196W YDL196W SGTC_778 3456-2434 196 µM 1.00543482866432 0.150742998908352 no 518 0.157343758072856 893 5539063 SGTC_832 4083-0019 164 µM 1.00491232183883 0.150868906833266 no 519 0.157469535331699 964 1990758 SGTC_390 dec-rvkr-cmk 16.7 µM 1.00387123710136 0.151119984580432 no 520 0.157720341025041 834 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1 SGTC_820 1582-0060 59.9 µM 1.00380092734899 0.151136951154919 no 521 0.157737288664193 804 3848840 SGTC_698 k064-0052 127 µM 1.00307311066802 0.151312656384475 no 522 0.157912793701662 803 5088751 SGTC_1964 st076914 61 µM 1.00066259665142 0.151895558286754 no 523 0.158494978056372 818 24208661 SGTC_568 1193-0097 7.48 µM 0.999130250647144 0.152266879310879 no 524 0.15886579933357 805 3646150 SGTC_857 0438-0306 1.35 µM 0.998344715078918 0.152457465246779 no 525 0.159056115918987 800 4686136 SGTC_75 0159-0059 199.013 µM 0.997951886464828 0.152552832325887 no 526 0.159151344952759 776 5377270 SGTC_2415 st077333 57.7 µM 0.992913474350234 0.153779517712165 no 527 0.160376061371579 901 2766255 SGTC_235 0330-0087 5 mM 0.991294688413505 0.154175020194443 no 528 0.160770852934347 838 46494818 YHR062C RPP1 SGTC_2873 9040596 71.43 µM 0.990302502774396 0.154417763690193 no 529 0.161013141821677 797 6463863 SGTC_445 e6 berbamine 66 µM 0.988412024774145 0.15488097820544 no 530 0.161475450384116 902 6610268 A calcium/calmodulin antagonist. SGTC_3217 9129673 49.47 µM 0.987704476573656 0.155054581053452 no 531 0.161648700735808 767 17248312 SGTC_1196 1588-0294 184 µM 0.982731740525643 0.156278306852833 no 532 0.162869742350681 772 6144269 SGTC_1346 1488-2224 62.4 µM 0.982687013779148 0.156289342314746 no 533 0.162880752024067 839 3722427 SGTC_435 c-PAF 6.7 µM 0.982384910950997 0.156363893802496 no 534 0.16295512855577 835 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase SGTC_852 0418-0143 439 µM 0.980790542913348 0.15675773223049 no 535 0.163348021415113 900 5369229 SGTC_492 tmb-8 126 µM 0.980607640106631 0.156802954316109 no 536 0.163393132635905 666 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1 SGTC_722 3534-0461 190 µM 0.979434624019854 0.157093182544944 no 537 0.163682638142435 823 658262 SGTC_487 nimodipine 119 µM 0.978003610729039 0.157447722675245 no 538 0.164036269134844 722 4497 L-type voltage-gated calcium channels inhibitor SGTC_1510 1123-0200 71.5 µM 0.977468297970717 0.157580483927444 no 539 0.164168682533824 889 5378812 YNL149C | YNL150W PGA2 | YNL150W SGTC_3337 9144342 33.5465 µM 0.977404381759381 0.157596340502329 no 540 0.164184497292466 839 17682949 SGTC_1022 4477-0945 21.3 µM 0.977304824831069 0.157621041048909 no 541 0.164209132585251 804 4648966 SGTC_1541 2',3',6-trimethoxyflavone 64 µM 0.977230991184523 0.15763936116972 no 542 0.164227404217883 898 688801 SGTC_1534 6-azauridine 81.6 µM 0.976718463559605 0.1577665716679 no 543 0.164354275908947 887 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1 SGTC_632 0781-2353 4.65 µM 0.976017631960118 0.157940628737817 no 544 0.164527863412015 836 6811515 YHR007C ERG11 SGTC_2851 9015922 71.43 µM 0.974839039404288 0.158233625726847 no 545 0.164820054354514 814 2996893 SGTC_436 n,n-dimethylsphingosine 3.3 µM 0.971395567456201 0.159091711703996 no 546 0.165675667487114 842 5282309 SGTC_2678 equilin 100 µM 0.970959285113204 0.159200646994514 no 547 0.165784276921783 854 3247 Equilin is an estrone commonly used hormone replacement therapy SGTC_630 4356-0227 183 µM 0.970632835940584 0.159282190000133 no 548 0.165865574256615 793 779312 SGTC_3339 9145883 14.936 µM 0.969936690963585 0.159456169828115 no 549 0.166039024910528 787 2030670 SGTC_1899 st063254 59.6 µM 0.966780020521275 0.160246642069826 no 550 0.166827007174509 740 3093813 SGTC_1467 k284-1082 293 µM 0.964002528615721 0.160944277642233 no 551 0.167522329068833 863 3334705 SGTC_1190 1486-1332 13 µM 0.961588265389578 0.161552287469126 no 552 0.1681282341839 847 4150046 SGTC_2171 5739187 198.077 µM 0.959992298019416 0.161955038144025 no 553 0.168529545633832 778 2262761 SGTC_810 3825-7150 143 µM 0.959752349932318 0.162015646805693 no 554 0.168589934612967 905 22330411 YGL099W LSG1 SGTC_49 0717-0965 32.132 µM 0.958936996214768 0.162221707972981 no 555 0.168795242839099 877 5889349 YGL099W LSG1 SGTC_809 3998-0021 90 µM 0.958895423040088 0.162232219169403 no 556 0.168805715377473 826 715485 SGTC_792 4534-1957 155 µM 0.958144928445932 0.162422047496886 no 557 0.168994841375523 843 1717904 SGTC_334 1502-1024 68.5 µM 0.957910138452662 0.162481464397372 no 558 0.16905403681826 870 3296216 SGTC_2887 9044784 58.44 µM 0.955240478285319 0.163158053947534 no 559 0.169728050052721 955 6465546 SGTC_2927 9011802 47.9 µM 0.949445396192953 0.164633031274566 no 560 0.171197065546513 809 43912568 SGTC_15 0266-0086 27.098 µM 0.949212429849355 0.164692506485734 no 561 0.171256290488415 950 1712902 YIL048W NEO1 SGTC_1771 st048882 4.1505 µM 0.947986579742017 0.165005689554974 no 562 0.171568143137521 841 4580403 SGTC_3179 9107801 49.47 µM 0.947778961908534 0.165058770408239 no 563 0.171620996410696 858 4818259 SGTC_3205 9113483 49.47 µM 0.94580983624632 0.165562758759252 no 564 0.172122793849511 858 17018033 SGTC_1618 st003135 44.5 µM 0.945063281985809 0.16575409570076 no 565 0.172313284787069 842 1270615 SGTC_685 1278-0033 54.9 µM 0.944803434853473 0.165820726335528 no 566 0.172379618976776 879 3590572 SGTC_1983 st071813 46.9 µM 0.941816673262767 0.166587842052327 no 567 0.173143253648324 845 11838595 SGTC_1711 st032263 62.8 µM 0.940557184326321 0.166912012952703 no 568 0.173465915976716 839 3958979 SGTC_2989 9073649 71.4286 µM 0.939940962109009 0.167070766144547 no 569 0.17362392228309 933 21367202 SGTC_869 0564-0080 44.1 µM 0.93724258782959 0.167767076356124 no 570 0.174316893817578 844 6843321 SGTC_3317 9138495 8.753 µM 0.936886398424838 0.16785912974983 no 571 0.17440849820418 869 17020139 SGTC_163 TUB2.036 7.546 µM 0.936791191385424 0.167883740511086 no 572 0.174432988620868 976 15992207 YJR013W GPI14 SGTC_1173 0443-0020 122 µM 0.936399216674595 0.167985089376782 no 573 0.174533840561041 858 5331295 SGTC_1432 4049-0298 68.4 µM 0.932176026202959 0.169079533170914 no 574 0.17562278145927 889 741646 SGTC_1044 1222-0021 1.78 µM 0.928041147113898 0.170155517223994 no 575 0.17669311301581 850 4306703 SGTC_426 0988-0037 14.6 µM 0.927915767383483 0.170188212107699 no 576 0.176725632402787 923 5383008 SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM 0.926132130690021 0.170653761418556 no 577 0.177188658951163 843 279621 SGTC_2100 5377183 190 µM 0.926059022049099 0.170672860975563 no 578 0.177207654060166 955 2844202 SGTC_166 k072-0058 166.424 µM 0.922542984597258 0.171593037251821 no 579 0.178122709936067 927 5846229 SGTC_1556 plumbagin 1.48 µM 0.92247069589025 0.171611989002833 no 580 0.178141554414549 841 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM 0.922272415891238 0.17166397844273 no 581 0.178193249203951 920 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_3054 9094397 49.47 µM 0.921811506326249 0.171784868790581 no 582 0.178313452281916 910 2598354 SGTC_1754 st042065 16.137 µM 0.920950002791126 0.172010975279071 no 583 0.178538265378264 955 1126236 YIL048W NEO1 SGTC_567 1080-0542 68.4 µM 0.920056452011393 0.172245693371984 no 584 0.178771629860148 838 5950415 SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM 0.919142499571064 0.172485981891881 no 585 0.179010521103335 922 23847180 SGTC_1103 duloxetine 36.1 µM 0.918079909775292 0.172765617495132 no 586 0.179288515955928 979 60835 A selective serotonin reuptake inhibitor. SGTC_1836 st055642 81 µM 0.914444567524694 0.173724493363088 no 587 0.180241646306224 914 8571 SGTC_694 1315-0438 43.2 µM 0.914330841638036 0.173754544776032 no 588 0.180271514676778 824 6793154 SGTC_826 1683-5028 118 µM 0.913486485457705 0.173977764455641 no 589 0.180493369087556 880 722377 SGTC_2502 avocadyne acetate 18.59 µM 0.912213088346612 0.17431475295452 no 590 0.180828277663762 988 3952079 SGTC_291 SEC14.278 35.5 µM 0.910226150690704 0.174841398785772 no 591 0.181351627795204 930 1068044 SGTC_327 1273-0057 3.96 µM 0.909458728087428 0.175045077301823 no 592 0.181554016972081 862 3108138 SGTC_2594 a-mangostin 100 µM 0.907568018187269 0.175547524911562 no 593 0.182053248919521 896 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis. SGTC_2741 miltefosine 3.04 µM 0.907493928927746 0.175567232389718 no 594 0.182072829255747 806 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis. SGTC_1171 0368-0077 21.4 µM 0.906364962896048 0.175867706763267 no 595 0.182371355671549 853 3239779 SGTC_373 0844-0104 25.9 µM 0.904769262234626 0.176292957723751 no 596 0.182793819468291 962 5375804 SGTC_1150 3909-7983 10.9 µM 0.899967487975249 0.177576541608996 no 597 0.184068776443557 906 23965914 SGTC_649 1123-0311 367 µM 0.898559520372099 0.177954027246466 no 598 0.184443664158138 945 693629 YIL048W NEO1 SGTC_185 k048-0037 25.491 µM 0.898379416127206 0.178002350891601 no 599 0.184491653243435 944 6827589 SGTC_2743 auranofin 4.32 µM 0.898204078636247 0.178049403520128 no 600 0.184538379678755 891 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold. SGTC_2453 5731132 22.18 µM 0.897829724704173 0.17814988937479 no 601 0.184638167483627 955 1362040 SGTC_2109 5483026 200 µM 0.894261333782366 0.179109527498068 no 602 0.185591041423705 913 759335 SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM 0.893375286583355 0.17934831293366 no 603 0.185828116316748 914 115019 SGTC_1894 3',6'-dihydroxyflavone 78.7 µM 0.890390455610655 0.18015418245169 no 604 0.186628132744101 900 688662 SGTC_3157 9099274 49.47 µM 0.889947616581343 0.180273937155766 no 605 0.186747007129145 914 17217662 SGTC_2143 5623677 140.463 µM 0.889479806140334 0.180400498999792 no 606 0.186872635661176 904 5375313 SGTC_2218 6965428 192.983 µM 0.888302006865673 0.180719388618995 no 607 0.187189160237063 925 675684 SGTC_3064 1327-0027 10 µM 0.886347435450569 0.181249368956515 no 608 0.187715167529153 796 16000455 YPR107C YTH1 SGTC_205 1486-1330 71.903 µM 0.885571072076328 0.181460149032365 no 609 0.187924352782306 898 4118834 SGTC_495 decylubiquinone 155 µM 0.882883279793243 0.182191060225641 no 610 0.188649669183302 867 2971 A Co-enzyme Q analog. A free radical scavenger. SGTC_1912 st060209 90.8 µM 0.882565756353372 0.182277528087072 no 611 0.188735468566741 879 688787 SGTC_446 go6976 132 µM 0.87837474869383 0.183421223747424 no 612 0.18987019156422 915 3501 A protein kinase C inhibitor. SGTC_402 epigallocatechin gallate 10 µM 0.878239084228797 0.183458320193454 no 613 0.189906992917384 948 65064 An antioxidant. SGTC_2308 7584454 197.62 µM 0.877499930171098 0.183660518558348 no 614 0.190107578377866 971 893577 SGTC_1845 st056753 3.01 µM 0.8754802999231 0.184213703668514 no 615 0.190656312316311 943 5375839 SGTC_156 3474-0145 5.642 µM 0.874356157115297 0.184522059794839 no 616 0.190962162864104 929 2265471 SGTC_176 1486-1328 72.834 µM 0.873484389053222 0.184761409557515 no 617 0.191199555756444 977 22310231 SGTC_612 0302-0167 22.4 µM 0.871277980485901 0.185368055684428 no 618 0.191801195204585 1015 235821 SGTC_3301 9125354 19.7965 µM 0.87108493691817 0.185421191262024 no 619 0.191853889057322 871 41905162 SGTC_1224 0823-0416 294 µM 0.870021656703826 0.185714030419539 no 620 0.192144284585732 966 3598164 SGTC_95 0471-0001 561.058 µM 0.868510623439309 0.186130678999874 no 621 0.192557429580944 933 4015405 SGTC_1616 st002734 56.1 µM 0.86808990128674 0.186246790924576 no 622 0.192672559524892 967 4026101 SGTC_382 3229-0966 23.2 µM 0.864129249812681 0.187342060152559 no 623 0.193758446270699 990 5722370 SGTC_2335 9018011 154.17 µM 0.861115351908283 0.1881781785145 no 624 0.194587257365334 985 6458208 SGTC_1767 st044992 70.3 µM 0.860968822159598 0.188218887547898 no 625 0.194627607438148 977 9600693 SGTC_658 3253-0951 102 µM 0.856820737328957 0.1893735657763 no 626 0.195771981593705 1015 1184878 SGTC_548 1436-0017 110 µM 0.855299974839568 0.189797981511159 no 627 0.196192550738346 1025 9677137 SGTC_1271 0832-2808 169 µM 0.85517405761072 0.18983314880325 no 628 0.196227397878311 1006 3663794 SGTC_1665 st014639 11.4 µM 0.854137437190853 0.190122817689951 no 629 0.196514421447757 1021 981133 YIL048W NEO1 SGTC_2483 5729050 27.16 µM 0.854059313010381 0.190144659386104 no 630 0.196536063084098 1031 2865180 SGTC_2589 lobaric acid 100 µM 0.853106845720556 0.190411070966961 no 631 0.196800027732039 942 73157 A novel microtubule depolymerizer. SGTC_3098 9119039 49.47 µM 0.853035948669554 0.190430910516777 no 632 0.196819684562839 969 17161528 SGTC_2325 6158266 200 µM 0.852840808619893 0.190485524290238 no 633 0.196873794996802 933 3623240 SGTC_1468 k284-1086 134 µM 0.851626275213714 0.190825651461506 no 634 0.197210775710446 1017 15996457 SGTC_1739 st037196 92.5 µM 0.851481713111751 0.190866160533679 no 635 0.19725090869488 1016 612214 SGTC_1162 k048-0130 20.1 µM 0.851391751856702 0.190891372064814 no 636 0.197275886016805 948 6797406 SGTC_1321 1326-2144 215 µM 0.851205136511865 0.190943677300075 no 637 0.197327704995423 989 3513030 SGTC_2193 5925765 200 µM 0.850997105153783 0.191001995455776 no 638 0.197385480433332 960 877370 SGTC_726 3448-4391 34.2 µM 0.849454207892127 0.191434862110905 no 639 0.197814300271233 1008 1356692 SGTC_2665 lovastatin 100 µM 0.84694237444682 0.19214085275328 no 640 0.198513620977483 980 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1 SGTC_756 0508-1999 28.3 µM 0.845806556002089 0.192460614873851 no 641 0.198830333771484 921 6753853 SGTC_470 aa-861 153 µM 0.845540369666377 0.192535600208999 no 642 0.198904601479186 970 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor. SGTC_908 3448-7491 47.7 µM 0.844500430983779 0.192828724591136 no 643 0.199194911313484 1018 1203031 SGTC_2105 5350118 200 µM 0.844364629972221 0.192867022527343 no 644 0.199232840426903 985 2133313 SGTC_3211 9128781 49.47 µM 0.843964998969126 0.192979751457559 no 645 0.199344482276604 892 17194361 SGTC_2959 9079155 11 µM 0.840916316986253 0.193841055131676 no 646 0.200197408337688 931 16189457 SGTC_2803 7707263 71.43 µM 0.840117425542413 0.194067142200301 no 647 0.200421275359971 930 2199229 SGTC_2481 5478948 45.16 µM 0.839553170382005 0.194226923732524 no 648 0.200579482685586 937 77792 SGTC_154 3389-1638 511.116 µM 0.839329597240257 0.194290255648402 no 649 0.200642189439791 886 5238686 SGTC_1390 3413-2614 145 µM 0.83749400771336 0.194810701291215 no 650 0.201157471905176 1040 3421432 SGTC_496 calpeptin 138 µM 0.836455992289135 0.195105385311891 no 651 0.201449212140481 922 73364 A calpain inhibitor. SGTC_92 0063-0024 660.874 µM 0.836282505359275 0.19515466323425 no 652 0.201497996363927 1078 3594437 SGTC_734 2023-0417 80 µM 0.834083810161102 0.195779844648372 no 653 0.202116878796873 971 3935732 SGTC_2365 9042475 200 µM 0.832339732486978 0.196276622687329 no 654 0.202608604792304 995 6464479 SGTC_2428 5615643 7.78 µM 0.831189071890233 0.196604791552701 no 655 0.202933413665805 972 2253075 SGTC_2416 tofa 880 nM 0.830658524643213 0.196756215742463 no 656 0.20308328142491 888 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_530 4358-1714 28 µM 0.830221863372186 0.19688089678492 no 657 0.203206678051937 1023 1564641 SGTC_3305 9127027 53.8275 µM 0.830197663211236 0.196887808119317 no 658 0.20321351811277 985 41905295 SGTC_3281 9140613 49.47 µM 0.829389715775639 0.197118634483028 no 659 0.203441959502241 945 16013766 SGTC_1742 st038235 28.8875 µM 0.827539571479711 0.197647827541801 no 660 0.203965651385339 968 564103 YBR002C RER2 SGTC_2513 baicalein 25.65 µM 0.827446306820863 0.197674526559365 no 661 0.203992071626582 1007 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2 SGTC_2328 6201408 200 µM 0.826745068025426 0.197875341069323 no 662 0.204190785566156 936 2890418 SGTC_2882 9058044 58.44 µM 0.826489300991515 0.197948616012559 no 663 0.204263292376081 1012 18076804 SGTC_2905 7799065 20.05 µM 0.826294415565396 0.198004459925818 no 664 0.204318550288541 971 1296806 SGTC_1691 st019933 84.6 µM 0.825529165660472 0.198223832316129 no 665 0.204535615705703 1008 6176082 SGTC_2346 9031566 143.75 µM 0.824928476830746 0.198396133107444 no 666 0.204706098981807 998 4771086 SGTC_46 0329-0187a 2.197 µM 0.822461715532719 0.199104642689507 no 667 0.205407083592473 1039 46494817 SGTC_1240 0356-0016 42.1 µM 0.822116906954416 0.199203800791062 no 668 0.205505181989579 968 4305613 SGTC_106 0092-0003 11.579 µM 0.82209942458562 0.199208829063983 no 669 0.205510156482422 974 1072148 SGTC_3274 9138298 49.47 µM 0.820821213077062 0.199576674913251 no 670 0.205874056822024 1043 17015756 SGTC_1178 0988-0033 191 µM 0.820431083080387 0.199689028548212 no 671 0.205985200952931 1013 5392207 SGTC_3224 9130643 49.47 µM 0.820324327883474 0.199719779634217 no 672 0.206015620640335 1006 17644395 SGTC_310 1273-0058 1.06 µM 0.819134359596076 0.200062745635808 no 673 0.206354880134968 1088 2734232 SGTC_1919 st067113 52.3 µM 0.817013704166136 0.200674826080965 no 674 0.206960298256291 979 1268243 SGTC_2718 lomofungin 53.02 µM 0.816771107242291 0.200744917922131 no 675 0.207029623297173 997 5351222 A RNA synthesis inhibitor. SGTC_584 0986-0246 15.4 µM 0.816710994824294 0.200762288056217 no 676 0.207046803280344 1132 53315 YDR232W HEM1 SGTC_2519 cryptotanshinone 88.04 µM 0.813826419178207 0.201596877316267 no 677 0.207872198971178 1030 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE) SGTC_1059 3448-6867 171 µM 0.81204712450671 0.202112712415506 no 678 0.208382295835304 1043 3934407 SGTC_1275 0867-0008 21.1 µM 0.811702988234748 0.202212571992349 no 679 0.208481039636577 1024 3422836 SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM 0.811477793067776 0.202277933865458 no 680 0.208545670329459 1006 4330530 SGTC_2288 7946289 167.31 µM 0.810658033879073 0.202515971950594 no 681 0.208781039801722 1071 1246052 SGTC_789 1309-1135 70.6 µM 0.809077015096001 0.202975533937539 no 682 0.209235424160443 1071 3092424 SGTC_2993 9054257 71.4286 µM 0.808828403421289 0.203047855659501 no 683 0.209306928015334 1079 6470217 YGL055W OLE1 SGTC_1751 st044839 27.194 µM 0.80144302704535 0.205203289287805 no 684 0.211437607183106 1053 5291326 SGTC_2312 7706453 155.7 µM 0.800658173555139 0.205433146441518 no 685 0.211664781466048 1003 976098 SGTC_1377 2944-0135 198 µM 0.799389778166749 0.205804939787608 no 686 0.212032217838904 1058 1894137 SGTC_2749 bexarotene 57.39 µM 0.797708997548895 0.206298226483596 no 687 0.212519690631922 1005 82146 An retinoic acid receptor inhibitor. SGTC_1330 1469-0054 61.8 µM 0.795926536492202 0.206822119892888 no 688 0.213037368123908 1090 7102664 SGTC_2057 5236571 38.335 µM 0.794399428274007 0.207271586855162 no 689 0.213481468460094 1064 54684039 YBR257W POP4 SGTC_2986 9022445 71.43 µM 0.79348896870037 0.207539832992861 no 690 0.213746496930808 1033 6459286 SGTC_670 4204-0025 119 µM 0.789236073027843 0.20879556639736 no 691 0.214987021030126 1080 719039 SGTC_428 3448-4153 16.5 µM 0.788476264681262 0.20902038205156 no 692 0.215209088367207 999 3834874 SGTC_948 3448-0295 75.3 µM 0.788152213495925 0.209116307185364 no 693 0.215303838503093 1064 678569 SGTC_14 0354-0009 295 µM 0.786278282196342 0.209671533605075 no 694 0.215852236497376 1076 1713507 SGTC_188 3229-0966 278.469 µM 0.784468261791904 0.210208646057267 no 695 0.216382698974114 1172 5722370 SGTC_541 4513-1321 94 µM 0.782130537452421 0.210903545897046 no 696 0.21706893088612 995 747515 SGTC_2533 agelasine 13.65 µM 0.781872832611126 0.210980232246059 no 697 0.217144656241661 1098 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase. SGTC_102 gallobenzophenone 83.616 µM 0.781326481717048 0.211142866310079 no 698 0.217305249348997 1044 70837 SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM 0.779791213807037 0.211600267655544 no 699 0.217756889415705 1096 688788 SGTC_3169 9102970 49.47 µM 0.778580548931457 0.211961368950188 no 700 0.218113420381112 1103 17027839 SGTC_1242 0402-0103 60.1 µM 0.77821244716199 0.212071232948722 no 701 0.218221890025422 1036 432868 SGTC_1784 st039334 36.3 µM 0.778178577029157 0.212081343532899 no 702 0.218231872199678 1067 3496984 SGTC_1553 gossypol 38.6 µM 0.77675935668659 0.21250524873606 no 703 0.218650379938541 1019 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_2351 9026858 72.31 µM 0.774872884430753 0.213069482361241 no 704 0.219207388112011 1041 1409300 SGTC_2237 6667747 47.222 µM 0.773228702268804 0.213561960377872 no 705 0.219693521224245 1004 729940 YDL015C TSC13 SGTC_2139 5578692 56.4705 µM 0.773121149609918 0.21359419846912 no 706 0.219725342728997 1043 650991 YMR113W FOL3 SGTC_3261 9137475 49.47 µM 0.772985853949902 0.213634756340507 no 707 0.219765376287545 932 17027690 SGTC_904 1141-0088 396 µM 0.772513296905761 0.21377645098187 no 708 0.219905237274345 1068 1378119 SGTC_2450 5739737 12.93 µM 0.772171290524337 0.213879034578041 no 709 0.220006491511294 1049 2262825 SGTC_2400 5203494 178.7 µM 0.770460374893017 0.214392647789045 no 710 0.220513425767801 1039 6777674 SGTC_1487 3970-0795 2.82 µM 0.769388773445594 0.214714705240327 no 711 0.220831275588964 1089 3765103 SGTC_2707 st078556 66.6 µM 0.768965942278262 0.21484185957769 no 712 0.220956764516466 1054 17250899 SGTC_3300 9124615 50.48 µM 0.768127786638842 0.215094040086146 no 713 0.221205635126713 1079 24824903 SGTC_785 1270-0111 65.3 µM 0.767504329988514 0.215281734335603 no 714 0.221390859875643 1109 6741994 SGTC_653 0203-0016 55.2 µM 0.76720144202168 0.215372954326808 no 715 0.221480877837815 1093 295302 SGTC_2696 st077691 74.316 µM 0.766497306870523 0.215585103545819 no 716 0.221690226853471 1019 757133 SGTC_1351 1496-0003 46.5 µM 0.764492462852074 0.216189807266974 no 717 0.222286913281078 1112 3891978 SGTC_1399 3562-5772 25 µM 0.763133848193401 0.216600152142771 no 718 0.22269178772042 1012 23847490 SGTC_2056 5235370 200 µM 0.762726483953182 0.216723276856028 no 719 0.222813266302625 1038 5511916 SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM 0.76132014583499 0.217148649597116 no 720 0.223232935254994 1045 1241132 A phosphatase inhibitor. SGTC_1483 3453-0561 55.9 µM 0.760478372441824 0.217403489977741 no 721 0.223484346107084 1088 4546991 SGTC_1721 st082152 9.2685 µM 0.75997254367014 0.217556708744564 no 722 0.223635498462574 1074 5296051 SGTC_38 0929-0051 58.268 µM 0.759901502962734 0.217578232418728 no 723 0.223656731585902 1120 1379719 SGTC_2162 5663267 200 µM 0.758727697161686 0.217934046012631 no 724 0.224007732448769 1122 6456493 SGTC_655 k060-0012 42 µM 0.758172194566369 0.218102551390982 no 725 0.224173952344071 1091 5994525 SGTC_68 0986-0284 82.829 µM 0.754524659013612 0.219210853539695 no 726 0.225267122097466 977 423278 YIL048W NEO1 SGTC_1214 0358-0031 63.7 µM 0.754471347707352 0.219227076126191 no 727 0.225283121898421 1078 4301366 SGTC_2111 5486399 200 µM 0.753662691434276 0.219473234174052 no 728 0.225525894902712 1137 689674 SGTC_2238 6671620 73.2395 µM 0.751479943639262 0.220138463079707 no 729 0.22618193335612 1122 729941 SGTC_2061 5245884 80.95 µM 0.75147936257459 0.220138640322719 no 730 0.226182108142177 1131 573863 SGTC_2114 5491910 81.25 µM 0.751264017272431 0.220204333053213 no 731 0.226246889932744 1109 2849228 SGTC_1209 2323-2347 50.3 µM 0.750980680388471 0.220290784259535 no 732 0.226332141428901 1123 5412760 SGTC_1117 retinoic acid 1.10837 µM 0.750566775575745 0.220417109071493 no 733 0.226456711315282 1142 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR). SGTC_3114 9122766 49.47 µM 0.749513871442977 0.22073864520001 no 734 0.226773770566613 1036 17176985 SGTC_2376 9072922 81.32 µM 0.749115674729796 0.220860316583598 no 735 0.226893744114801 1150 17087968 SGTC_1398 3558-0053 112 µM 0.748712409266669 0.220983575878818 no 736 0.227015281316798 1044 4532369 SGTC_1427 4048-4900 550 nM 0.743274125477599 0.222649644823845 no 737 0.228657866733235 1117 24132586 SGTC_3003 9075612 71.4286 µM 0.743049229774829 0.222718697547132 no 738 0.228725937889777 1103 6501993 SGTC_3232 9132874 49.47 µM 0.74294297707315 0.222751325974546 no 739 0.228758102284821 1114 3784940 SGTC_2347 9049783 174.81 µM 0.742872920864288 0.222772840554564 no 740 0.228779310810594 1121 6467988 YPL169C MEX67 SGTC_2174 5790901 200 µM 0.742486927961977 0.222891401962799 no 741 0.228896184492584 1118 786020 SGTC_2745 rifampicin 24.3 µM 0.741313686083986 0.22325199502006 no 742 0.229251632661255 1032 25141428 Inhibits bacterial DNA-dependent RNA polymerase. SGTC_414 piperonyl butoxide 100 µM 0.741170866031954 0.223295913077013 no 743 0.229294922886775 1138 5794 A potent inhibitor of cytochrome P450. SGTC_2670 beta-carotene 100 µM 0.739064231479785 0.223944287241218 no 744 0.229933997583812 1080 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.) SGTC_2452 5863136 48.41 µM 0.738713803116469 0.224052244794296 no 745 0.23004040116944 1125 2184096 SGTC_3195 9113082 49.47 µM 0.737333179798407 0.224477865272142 no 746 0.230459879743473 1098 17018038 SGTC_1393 3470-5649 58.2 µM 0.736932965228502 0.224601329699352 no 747 0.230581557925654 1038 4108395 SGTC_2526 patulin 37.61 µM 0.736646996536907 0.224689573369605 no 748 0.230668523649492 1155 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.  SGTC_2298 7976326 193.81 µM 0.736619019778769 0.224698207439796 no 749 0.230677032624344 1053 2235818 SGTC_913 3487-1245 167 µM 0.735250197657039 0.225120877367875 no 750 0.231093566353504 1101 4016153 SGTC_3040 9091894 49.47 µM 0.734381589053797 0.225389322971224 no 751 0.231358102229343 1059 25236966 SGTC_796 1234-0020 70.7 µM 0.734079616223288 0.225482690848525 no 752 0.231450107993066 1133 46495034 SGTC_797 k781-0471 270 µM 0.734004941706343 0.225505783060394 no 753 0.23147286313931 1138 23738129 SGTC_1573 oleylamine 1.06 µM 0.732355939066332 0.226016058669111 no 754 0.23197567223109 1153 5356789 An amine of the fatty acid oleic acid. SGTC_442 cape 100 µM 0.732016021276849 0.226121325609715 no 755 0.232079394527668 1093 5281787 SGTC_1759 st043059 70 µM 0.731712580886001 0.226215319503551 no 756 0.232172007940008 1149 669426 SGTC_3188 9110789 49.47 µM 0.730304413322959 0.226651803225151 no 757 0.232602065583521 1160 849217 SGTC_2399 5884133 200 µM 0.7294054966371 0.226930684996199 no 758 0.232876828245959 1160 722445 SGTC_3148 9097893 49.47 µM 0.728451567995398 0.227226845337753 no 759 0.233168602942136 1110 17174100 SGTC_1419 3993-2473 62.6 µM 0.727475016563862 0.227530254747245 no 760 0.233467507282067 1168 704026 SGTC_1966 st070145 16.1 µM 0.726667784753557 0.227781229587269 no 761 0.233714746390731 1123 3748532 SGTC_2009 4012297 12.05 µM 0.725947809657237 0.228005207004362 no 762 0.233935382895241 1121 45595307 SGTC_3072 9116419 49.47 µM 0.724765802055437 0.228373186838279 no 763 0.234297859459019 1130 17170162 SGTC_91 0417-1751 58.384 µM 0.721020750813715 0.229541288523222 no 764 0.235448373854533 1275 6795624 SGTC_2839 9003951 25.97 µM 0.720120945286219 0.229822440679977 no 765 0.235725266241628 1149 2990634 SGTC_2664 lyso-paf C-16 73.48 µM 0.719414088930354 0.230043439327793 no 766 0.235942909281403 1176 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_2647 atorvastatin 60.16 µM 0.719413912848858 0.230043494394486 no 767 0.23594296351118 1123 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7 SGTC_2855 9016525 58.44 µM 0.719270846176653 0.230088238663049 no 768 0.235987027615839 1200 43811474 SGTC_2421 5690543 90.72 µM 0.71867702513246 0.230274008928662 no 769 0.236169971177891 1147 3397993 SGTC_3218 9131285 49.47 µM 0.718426629709682 0.230352367468644 no 770 0.236247136060157 1174 17156417 SGTC_2019 4016004 108 µM 0.718178972872884 0.230429883660918 no 771 0.236323470642226 1138 45595336 SGTC_127 0180-0333 59.125 µM 0.717926556484499 0.230508904588412 no 772 0.236401286219864 1150 771601 SGTC_2488 5268135 45.7 µM 0.717601483342676 0.230610693590783 no 773 0.236501521385275 1159 1270356 YLR208W SEC13 SGTC_1554 st069299 38.7 µM 0.714983185636424 0.231431467103514 no 774 0.237309716597504 1165 24207999 SGTC_899 1083-0020 478 µM 0.713859633944664 0.231784172442976 no 775 0.2376569900669 1181 767123 SGTC_2451 5856223 45.7 µM 0.712662813799386 0.232160207373939 no 776 0.238027216237372 1146 2179896 SGTC_2207 7258803 200 µM 0.712561988618855 0.232191901643122 no 777 0.238058420084129 1124 3666799 SGTC_1019 4262-0212 3.4 µM 0.712288687835979 0.232277825510622 no 778 0.238143013758386 1235 4677213 SGTC_2550 chrysin dimethyl ether 71.87 µM 0.711285623897068 0.2325933334154 no 779 0.238453629161847 1038 88881 An O-methylated flavonoid and antioxidant. SGTC_458 nppb 133 µM 0.710654972458338 0.232791823068908 no 780 0.238649034369604 1177 4549 A chloride channel blocker. SGTC_2001 4023502 57.655 µM 0.71038990927893 0.232875276474418 no 781 0.238731189443493 1154 108941 YCR052W RSC6 SGTC_276 colchicine 750 µM 0.710105831010155 0.232964735104661 no 782 0.238819255329686 1224 2833 A microtubule depolymerizer. SGTC_3308 9128332 17.569 µM 0.708799870763851 0.233376238412252 no 783 0.2392243389954 1189 17332805 YDL196W YDL196W SGTC_2012 4023501 200 µM 0.707304344796235 0.233847968118037 no 784 0.239688683047203 1150 3477460 SGTC_1072 oxiconazole 14.9 nM 0.706803644477433 0.234006020649759 no 785 0.239844254719722 1175 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_55 0767-0285 6.563 µM 0.705194999186214 0.234514210564576 no 786 0.240344446487902 1162 3116166 SGTC_269 exalamide 29 µM 0.704484192893761 0.234738956945773 no 787 0.240565645317173 1140 3316 A derivative of salicylamide. SGTC_366 0181-0206 4.31 µM 0.703748787280375 0.234971606545249 no 788 0.240794615924165 1193 274874 SGTC_791 1348-1292 225 µM 0.703579691582366 0.235025118906289 no 789 0.240847281108601 1197 5437054 SGTC_2886 9058944 51.95 µM 0.703417021292442 0.235076604223131 no 790 0.240897951000626 1055 4949929 SGTC_2805 7950783 58.44 µM 0.703399965435314 0.235082002780577 no 791 0.240903264036416 1173 1178958 YDL195W SEC31 SGTC_2277 7947813 106.88 µM 0.702870305591311 0.23524968596112 no 792 0.241068289031572 1202 1246798 SGTC_3091 9116372 49.47 µM 0.702250817648769 0.235445891270387 no 793 0.241261379538153 1202 17169793 SGTC_988 1497-1057 103 µM 0.700739131920166 0.235925053865226 no 794 0.241732915090696 1187 3533044 SGTC_2245 6637752 200 µM 0.700709410398668 0.235934480150555 no 795 0.241742191046248 1152 681890 SGTC_1973 st070275 50.2 µM 0.700171376166507 0.236105155489697 no 796 0.241910142550921 1136 17118334 SGTC_1660 st012960 28.1 µM 0.699881964624477 0.236196990810224 no 797 0.242000510755964 1171 24207266 SGTC_2246 7293507 91.5585 µM 0.697079662975082 0.237087226650627 no 798 0.242876470338956 1223 887656 SGTC_675 1309-0189 238 µM 0.697033485399708 0.237101911778501 no 799 0.242890919145683 1169 4246530 SGTC_249 wiskostatin 11.211 µM 0.696814387867766 0.23717159473083 no 800 0.242959480358298 1207 2775510 A n-wasp and actin depolymerizer. SGTC_506 n9-isopropylolomoucine 153 µM 0.696584525449337 0.237244713497208 no 801 0.243031421430942 1197 6610355 SGTC_2080 5212524 12.4 µM 0.696080578497557 0.237405061314684 no 802 0.243189184281241 1168 260183 SGTC_88 0180-0332 8.668 µM 0.695983033309218 0.237436105497102 no 803 0.243219727633806 1242 3101745 SGTC_538 2922-0838 53.3 µM 0.692408532045248 0.238575241938768 no 804 0.244340404624264 1240 777039 SGTC_779 1360-0071 233 µM 0.691809234376299 0.238766520908231 no 805 0.244528568360973 1264 7566 SGTC_1284 0929-0043 16 µM 0.690374192371857 0.239224886758608 no 806 0.244979450937429 1181 1239883 SGTC_203 k066-0004 30.888 µM 0.689715667495977 0.239435386598629 no 807 0.24518650558404 1276 6795412 SGTC_621 3584-0052 32.1 µM 0.688854732510621 0.23971074005237 no 808 0.245457344272488 1215 2273927 SGTC_1416 3966-0321 25.3 µM 0.687714862158966 0.240075571296487 no 809 0.245816179485162 1223 582530 YLR208W SEC13 SGTC_501 nsc-95397 161 µM 0.686828999408247 0.240359312812293 no 810 0.246095246549199 1217 262093 SGTC_1218 1348-1416 30.7 µM 0.686654794673542 0.240415132012156 no 811 0.24615014501997 1207 6787668 SGTC_746 1095-0025 46.6 µM 0.686637257587915 0.240420751688503 no 812 0.246155671979781 1214 6749286 SGTC_1167 k781-0610 148 µM 0.686488109783132 0.240468548290485 no 813 0.246202679852844 1228 4525169 SGTC_2791 5663188 71.43 µM 0.686413871420425 0.240492340991668 no 814 0.24622607982938 1189 54690634 SGTC_1581 himbacine 57.9 µM 0.685466656124018 0.240796027136993 no 815 0.246524747306342 1212 5281825 An alkaloid muscarinic receptor antagonist. SGTC_1673 st016611 27.3 µM 0.685222957278101 0.240874193017059 no 816 0.246601619632082 1220 5226799 SGTC_3132 9126706 49.47 µM 0.684851313481339 0.240993423536407 no 817 0.246718875609398 1227 850858 SGTC_1938 st074717 56.4 µM 0.684782006669811 0.241015662052604 no 818 0.246740745650839 1125 17250979 SGTC_2479 5617353 43.85 µM 0.683868012959657 0.241309040109323 no 819 0.247029257102373 1243 2731746 SGTC_1529 apigenin 74 µM 0.683614793461717 0.241390354024612 no 820 0.247109220340491 1263 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_732 3970-1727 52.7 µM 0.68131805985312 0.242128561108669 no 821 0.247835129120791 1219 1275699 SGTC_1203 3992-3522 103 µM 0.681074350670125 0.242206964923784 no 822 0.247912222929242 1344 5322312 SGTC_477 mead ethanolamide 10 µM 0.680761795099993 0.242307537487385 no 823 0.248011114008151 1103 16061185 SGTC_1322 1348-1070 12 µM 0.679677832203541 0.242656504906649 no 824 0.248354237664419 1200 6758089 SGTC_81 0411-0046 9.971 µM 0.678959238521584 0.242887996472763 no 825 0.248581844719945 1123 12925265 SGTC_882 0843-0131 351 µM 0.674458953941925 0.244340455564495 no 826 0.250009786429736 1256 5425421 SGTC_175 3793-3120 23.7 µM 0.672982881647416 0.244817872854125 no 827 0.250479090766493 1233 5322297 SGTC_1433 4060-0023 7.6 µM 0.670965382472299 0.245471219249567 no 828 0.251121291387068 1245 3840627 SGTC_115 0527-0192 112.043 µM 0.670437936123251 0.245642181680869 no 829 0.251289329069549 1262 4233931 SGTC_631 k072-0230 41.5 µM 0.668629177342185 0.246228944265622 no 830 0.251866027761522 1256 5773147 SGTC_3059 1327-0034 3 µM 0.666741867090456 0.246841989282586 no 831 0.252468515523712 1201 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_1804 st050076 49.1 µM 0.665534801019149 0.247234502132042 no 832 0.252854246144674 1260 3895976 SGTC_965 1291-5240 308 µM 0.665049783337297 0.247392313763757 no 833 0.253009325955354 1242 2834598 SGTC_813 k007-0158 173 µM 0.662759928805529 0.248138097028261 no 834 0.253742160598255 1263 6523916 SGTC_2220 6782180 200 µM 0.662533210691909 0.248212002091113 no 835 0.253814779023654 1181 833803 SGTC_1208 2323-2347 50.3 µM 0.661421987645368 0.248574405788229 no 836 0.254170864497976 1247 5412760 SGTC_1006 4099-6547 255 µM 0.661157399267237 0.248660737652469 no 837 0.254255689027491 1263 3146833 SGTC_1704 st028805 70.8 µM 0.661063469990299 0.24869138943615 no 838 0.254285805433979 1245 2876101 SGTC_747 3448-8087 38.7 µM 0.660638732447973 0.248830018445515 no 839 0.254422011755243 1260 5168703 SGTC_1970 st070122 35.8 µM 0.660216434558745 0.248967891957315 no 840 0.254557473615927 1283 102928 SGTC_2412 st077135 33.4 µM 0.658463889657222 0.249540504026424 no 841 0.255120046619485 1318 13258915 SGTC_2084 5306078 60.6385 µM 0.658432057587637 0.249550911040532 no 842 0.255130270833796 1203 679340 SGTC_1976 st070609 63.5 µM 0.657721088252725 0.249783411799374 no 843 0.255358684512742 1207 682556 SGTC_803 4488-1585 147 µM 0.657361285917138 0.249901117955398 no 844 0.255474319211125 1223 747204 SGTC_968 1309-0633 340 µM 0.657356368164273 0.249902726958732 no 845 0.255475899887505 1234 3761976 SGTC_1811 st050069 61.5 µM 0.656950616680277 0.250035500738563 no 846 0.255606335142117 1241 3877702 SGTC_571 k831-0106 44.2 µM 0.655142716696028 0.250627553242475 no 847 0.256187935764163 1250 4783639 SGTC_2964 9083345 53.42 µM 0.654400224948341 0.250870919961935 no 848 0.256426994761095 1226 17741579 SGTC_833 3852-0053 558 µM 0.653830813689295 0.251057640759564 no 849 0.25661040600223 1313 3123681 SGTC_3032 9089427 49.47 µM 0.65373186807358 0.251090094408356 no 850 0.256642284024289 1241 17173707 SGTC_2270 7924575 90.91 µM 0.653346667377131 0.251216459374052 no 851 0.256766406546978 1253 1262135 SGTC_1557 sumaresinolic acid 42.3 µM 0.652901767331312 0.251362450534899 no 852 0.256909804762097 1216 9982268 A natural terpine and antifungal of unknown mechanisn. SGTC_1628 st004252 77.7 µM 0.650919050003702 0.252013611702058 no 853 0.257549371741483 1267 692968 SGTC_1820 st053765 18.6 µM 0.650772568868573 0.25206175410806 no 854 0.257596655079998 1238 3690829 SGTC_1479 0549-0158 134 µM 0.647598819170541 0.253106027146958 no 855 0.258622230612576 1303 5440202 SGTC_2275 7947463 200 µM 0.644708370989734 0.254059060611309 no 856 0.259558095278891 1230 1225414 SGTC_306 1672-3436 11.6 µM 0.643597529360056 0.254425825481492 no 857 0.259918226387972 1284 6797378 SGTC_3045 9092950 49.47 µM 0.642087085760115 0.254924971106326 no 858 0.260408320263901 1330 44120432 SGTC_2843 9000894 45.46 µM 0.64201701275537 0.254948140069111 no 859 0.260431068410485 1152 2242070 SGTC_2221 6807166 181.081 µM 0.641781503350611 0.25502601705515 no 860 0.260507530494535 1244 674925 SGTC_686 1319-0111 510 µM 0.640816664441288 0.255345194692314 no 861 0.260820902293124 1356 4562600 SGTC_891 0929-0073 133 µM 0.640288224782167 0.255520095872793 no 862 0.260992617334673 1323 5603632 SGTC_2054 5233173 129 µM 0.638945205964832 0.255964885217695 no 863 0.261429289124086 1301 6889 SGTC_1877 wortmannin 25 µM 0.638356357080453 0.256160031175177 no 864 0.26162086685572 1273 312145 A covalent inhibitor of PI 3-kinase. SGTC_1844 rapamycin 4 nM 0.636038875800748 0.256928802963642 no 865 0.262375541824997 1245 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2 SGTC_2336 9001819 198.65 µM 0.634992030439732 0.257276463331552 no 866 0.262716806379704 1371 2989602 SGTC_1509 1326-1131 80 µM 0.633860512696431 0.257652518447649 no 867 0.263085928756711 1253 768313 SGTC_1617 st002906 78 µM 0.633599814547232 0.257739200805221 no 868 0.263171010946374 1308 5150859 SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM 0.632392039565517 0.258140984452987 no 869 0.263565367159967 1241 2333 A French combination drug. SGTC_1228 0124-0032 52.5 µM 0.631465275368774 0.258449505889355 no 870 0.263868173570442 1355 X1228 SGTC_3088 9117578 49.47 µM 0.631370923934264 0.258480926358096 no 871 0.263899011442106 1347 678341 SGTC_2126 5251174 33.877 µM 0.630588724322801 0.258741486949724 no 872 0.264154736697698 1349 790722 SGTC_219 mitoxanthrone 164.414 µM 0.630008906048426 0.258934719455046 no 873 0.264344378661716 1310 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA.  YMR168C CEP3 SGTC_978 1416-0512 87.4 µM 0.629108696090958 0.259234874798304 no 874 0.264638948856354 1328 6814003 SGTC_1914 st062367 72.6 µM 0.62797816530466 0.259612080156851 no 875 0.265009121883126 1305 978205 SGTC_1234 0326-0494 15.5 µM 0.627244358191562 0.259857068906632 no 876 0.265249535227616 1353 1547813 SGTC_43 0570-0105 72.5 µM 0.62640162485583 0.260138570820174 no 877 0.265525772035581 1340 1114046 YDL195W SEC31 SGTC_1525 8-methoxypsoralen 92.5 µM 0.625334771368744 0.26049516189679 no 878 0.265875681646345 1349 4114 Related to psoralen; DNA damaging agent. SGTC_1609 st001574 46.4 µM 0.625002549137168 0.260606257086163 no 879 0.265984692522045 1279 3960012 SGTC_197 4544-0043 41.561 µM 0.62402411250559 0.26093358814805 no 880 0.266305874867504 1302 896523 SGTC_1380 2291-0730 164 µM 0.621909195341631 0.26164184481855 no 881 0.267000789183438 1291 2999191 SGTC_770 0389-1121 67.2 µM 0.621595555888681 0.261746962298917 no 882 0.267103921990142 1399 6753108 SGTC_1950 st077106 7.18 µM 0.620446691613183 0.262132193576803 no 883 0.267481870119312 1291 13831864 SGTC_611 3453-1652 23.7 µM 0.619340140445526 0.26250351114042 no 884 0.267846153073738 1323 1560575 SGTC_1184 1269-1718 139 µM 0.619129643342959 0.262574176635448 no 885 0.267915478201088 1363 5403821 SGTC_920 mycophenolic acid 780.421 nM 0.617512821089865 0.263117280681014 no 886 0.268448263622198 1315 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_1724 st037281 8.293 µM 0.615768882169442 0.263703727045477 no 887 0.269023533911944 1320 574124 YDL195W SEC31 SGTC_1928 4'-methoxychalcone 40.3 µM 0.614232637693937 0.264220882333775 no 888 0.269530804468348 1384 641818 SGTC_514 4466-0038 2.65 nM 0.613237566982185 0.264556134434788 no 889 0.269859634124715 1279 5722064 SGTC_515 4092-1064 102 µM 0.6126296284999 0.26476106316439 no 890 0.270060631400761 1384 717353 SGTC_2834 9001755 58.44 µM 0.612479519504289 0.26481167551832 no 891 0.270110272126524 1327 2989575 SGTC_1365 1672-3266 55.4 µM 0.612158989538981 0.264919765290938 no 892 0.270216285981924 1316 6415873 SGTC_893 0958-0369 48.9 µM 0.611090448259752 0.265280262867925 no 893 0.270569851477466 1366 6819948 SGTC_1066 ketoconazole 628 nM 0.610881146029258 0.265350905063463 no 894 0.270639133740573 1375 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W SGTC_2492 derrusnin 100 µM 0.610854789120371 0.265359801536127 no 895 0.270647858911578 1250 1715307 Part of coumarin class of compounds. SGTC_652 0437-0092 114 µM 0.61027528968346 0.265555443180082 no 896 0.270839731455039 1294 3091274 SGTC_1278 0874-0585 172 µM 0.609888454269971 0.265686081282965 no 897 0.270967850623198 1318 766306 SGTC_727 3032-0951 202 µM 0.60968049644554 0.265756324139409 no 898 0.27103673836191 1330 3652836 SGTC_2476 5806916 10.51 µM 0.607539310796576 0.266480109173628 no 899 0.271746531331435 1274 2870194 SGTC_2754 granisetron 64.02 µM 0.60751608568705 0.266487965420812 no 900 0.271754235414953 1361 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients. SGTC_3253 9135987 49.47 µM 0.607163838755424 0.266607132673605 no 901 0.271871093820001 1331 4182430 SGTC_2744 captopril 92.04 µM 0.606965711833201 0.266674172039354 no 902 0.271936833683491 1348 44093 angiotensin-converting enzyme (ACE) inhibitor  SGTC_1021 4476-0760 85.3 µM 0.606898932966895 0.266696769640963 no 903 0.271958993148126 1292 746768 SGTC_1282 0886-0010 32.4 µM 0.605676273271233 0.267110681996455 no 904 0.272364871277982 1377 2836211 YNL267W PIK1 SGTC_466 geldanamycin 89.2 µM 0.603566394148338 0.267825710538819 no 905 0.273065980586842 1251 5288382 HSP90 inhibitor. SGTC_1304 1165-0502 251 µM 0.602552921215585 0.268169514451929 no 906 0.273403073710338 1349 767425 SGTC_896 0964-0007 44.5 µM 0.60253114512814 0.268176904065642 no 907 0.27341031895596 1322 6756758 SGTC_2910 7948405 25.97 µM 0.601980416799456 0.268363825214736 no 908 0.273593586501393 1335 2971328 SGTC_468 gf-109203x 121 µM 0.601250310311365 0.268611729571937 no 909 0.273836639939092 1279 2396 A protein kinase C inhibitor. SGTC_1661 st013063 9.66 µM 0.601177243937615 0.268636545262392 no 910 0.273860969709526 1367 721395 SGTC_1471 k673-0312 37 µM 0.601121418250126 0.268655506237651 no 911 0.27387955936596 1337 24099884 SGTC_1879 gemcitabine 100 µM 0.600391291950537 0.268903552660192 no 912 0.274122744953315 1341 60750 A nucleoside analog which inhibits DNA replication. SGTC_2435 5706476 10.6 µM 0.600180289300869 0.268975258179844 no 913 0.274193044168957 1366 5725375 SGTC_1132 3456-3614 2.5 µM 0.597957066594194 0.269731363993827 no 914 0.274934290341066 1463 3125502 SGTC_406 estrone 100 µM 0.595047732757853 0.270722417743174 no 915 0.275905782400174 1425 5870 A steroid. SGTC_3183 9108214 49.47 µM 0.594435203373242 0.27093130505022 no 916 0.27611053443605 1272 4974831 SGTC_2326 6164455 177.58 µM 0.593001289010354 0.271420618748411 no 917 0.276590144800592 1354 2888790 SGTC_702 1488-0190 94 µM 0.5925699451126 0.271567898068014 no 918 0.276734498963753 1357 949357 SGTC_1107 amlodipine 47 µM 0.592019421466275 0.271755928261875 no 919 0.276918791593284 1257 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.  SGTC_1423 4048-0112 5.59 µM 0.591774528605036 0.271839591721158 no 920 0.277000790938698 1362 X1423 SGTC_1579 chlormadinone acetate 49.4 µM 0.591712931415118 0.271860637364988 no 921 0.277021417866498 1385 45114258 A steroidal progestin. SGTC_2667 digitoxin 100 µM 0.590097409886302 0.272412894844843 no 922 0.277562672612166 1329 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_1396 3511-0007 98.6 µM 0.589385473860193 0.272656443162513 no 923 0.277801359362762 1319 X1396 SGTC_2541 muurolladie-3-one 83.07 µM 0.588351986807832 0.273010184021438 no 924 0.278148028939557 1366 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils.  YMR203W TOM40 SGTC_2196 6573537 42.6665 µM 0.585196570403155 0.274091622402927 no 925 0.279207775343042 1425 2903087 SGTC_1634 st006576 41 µM 0.584306362191599 0.274397100858982 no 926 0.279507106254089 1393 3915356 SGTC_3004 9076122 71.4286 µM 0.58315099944246 0.274793818557946 no 927 0.279895827107638 1390 44782551 SGTC_206 4546-0025 72.014 µM 0.582991023579509 0.274848771857505 no 928 0.27994967151332 1372 6620745 YIL048W NEO1 SGTC_439 amiodarone 34.4 µM 0.582967365285853 0.274856899176341 no 929 0.279957634808112 1365 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1 SGTC_39 0986-0283 58.349 µM 0.582777481703238 0.27492213405503 no 930 0.280021552902979 1430 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2 SGTC_956 1185-0240 191 µM 0.581781373357449 0.275264473978766 no 931 0.280356976031887 1382 1416193 SGTC_2675 theaflavin digallate 100 µM 0.580753867806558 0.275617824132612 no 932 0.280703175381115 1370 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative. SGTC_1901 st060216 58.6 µM 0.579820819364785 0.275938884406959 no 933 0.281017728154231 1356 688792 SGTC_2163 5671233 125 µM 0.579430960793581 0.276073088425823 no 934 0.281149209161764 1466 701023 SGTC_629 3448-6466 76.7 µM 0.578985683419552 0.276226408878663 no 935 0.281299416669277 1358 573744 SGTC_2861 9024595 19.48 µM 0.578939423889134 0.276242339620517 no 936 0.281315023835051 1324 16482810 SGTC_2771 fluoxetine 41.05 µM 0.578736593945628 0.276312195012889 no 937 0.281383460085161 1413 3386 A selective serotonin reuptake inhibitor. SGTC_3191 9110352 49.47 µM 0.578701542465349 0.27632426775218 no 938 0.281395287515429 1402 17122424 SGTC_1827 berberine 7.24 µM 0.577003587972692 0.276909401869495 no 939 0.281968515868447 1268 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_533 1222-0222 6.71 µM 0.575092401479896 0.27756874307562 no 940 0.282614403308749 1477 3982874 SGTC_3087 9117406 49.47 µM 0.574414737141576 0.277802714929517 no 941 0.282843591327758 1346 42546093 SGTC_3319 9138450 16.7555 µM 0.571755670291943 0.27872171924727 no 942 0.283743756683818 1360 2029690 SGTC_1161 k007-0610 110 µM 0.569454797155442 0.279518120194738 no 943 0.284523769309324 1434 5843850 SGTC_3185 9108267 49.47 µM 0.569290378886093 0.279575072543808 no 944 0.284579547475068 1338 4910486 SGTC_1400 3771-8998 51.5 µM 0.56904731013703 0.279659278714506 no 945 0.284662017030456 1371 670767 SGTC_2712 st079126 47.7 µM 0.568910787861249 0.279706579447898 no 946 0.284708341979908 1330 3152970 SGTC_317 4495-0002 170 µM 0.568855510731191 0.27972573236279 no 947 0.284727099724454 1340 15991618 SGTC_2074 5212007 75.395 µM 0.567567994039042 0.280172022616712 no 948 0.28516417250167 1338 758611 SGTC_1020 4335-0961 93.3 µM 0.566864158523281 0.28041613797911 no 949 0.285403238366893 1320 669075 SGTC_1212 0520-0165 585 µM 0.564650955744251 0.281184426277799 no 950 0.286155599536952 1589 5403258 SGTC_3330 9141424 71.43 µM 0.563915877509492 0.281439825065231 no 951 0.286405691949489 1442 27261020 SGTC_1338 1486-1223 76 µM 0.563416904691567 0.28161325411217 no 952 0.286575514348738 1460 3444526 SGTC_3058 9093861 49.47 µM 0.563018489450965 0.281751769142273 no 953 0.286711146866686 1411 17217477 SGTC_2311 7694451 200 µM 0.562465277597668 0.281944155976989 no 954 0.286899527256877 1435 2163142 SGTC_52 0329-0193 875 nM 0.562103692752369 0.282069936140843 no 955 0.287022686263767 1466 3739292 SGTC_2847 9005661 71.43 µM 0.561951784021012 0.282122786860112 no 956 0.287074435194289 1321 2991449 SGTC_1288 0973-0013 65.5 µM 0.560688376550269 0.282562524832299 no 957 0.287504996188733 1440 4315430 SGTC_3283 9109332 35.8195 µM 0.559445711124116 0.282995364566825 no 958 0.287928786068033 1341 17027281 SGTC_2572 astragaloside iv 100 µM 0.558599068622105 0.283290445532618 no 959 0.288217687903307 1412 45006101 An anti-inflammatory agent. SGTC_1354 1498-1681 81 µM 0.558060767937725 0.283478136589832 no 960 0.288401444604517 1414 5754243 SGTC_2094 5332512 191.667 µM 0.557533168744386 0.283662154138755 no 961 0.288581601771852 1502 755774 SGTC_265 mycophenolic acid 32.932 µM 0.556285393430884 0.284097584298682 no 962 0.289007885410795 1461 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1 SGTC_2255 7941087 197.44 µM 0.555748894142709 0.284284902108992 no 963 0.289191263331107 1495 935561 SGTC_1443 4112-3303 14 µM 0.555107597134663 0.284508887295095 no 964 0.289410533339977 1386 704433 SGTC_2593 nobiletin 86.24 µM 0.552920950603709 0.28527324826645 no 965 0.290158770364673 1356 72344 An anti-infammatory. SGTC_1369 1866-0067 208 µM 0.551908984657625 0.285627320459195 no 966 0.290505356192766 1470 3531355 SGTC_1818 st052136 56.3 µM 0.551313147957999 0.285835892836648 no 967 0.290709513479032 1328 674169 SGTC_1142 3253-1408 9.78 µM 0.551219174784103 0.285868794716166 no 968 0.290741718540662 1407 256655 SGTC_263 alizarin 107.927 µM 0.547940281190605 0.287017926660899 no 969 0.291866454451144 1441 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. SGTC_1186 1319-0216 26 µM 0.546589461188318 0.28749197502247 no 970 0.292330405519276 1504 4565136 SGTC_1148 3909-7663 27.7 µM 0.545500650154569 0.287874344864623 no 971 0.292704616746202 1471 4084526 SGTC_3056 9094900 49.47 µM 0.545159343386978 0.287994254769465 no 972 0.292821965551935 1342 25236784 SGTC_923 1900-2434 73.3 µM 0.544939483363167 0.288071509772545 no 973 0.292897569849095 1374 5910570 SGTC_2767 sibutramine 71.45 µM 0.543654075531253 0.288523375440802 no 974 0.293339770284115 1506 64765 A serotonin-norepinephrine reuptake inhibitor.  SGTC_617 3770-0098 35 µM 0.543122061938328 0.288710494441008 no 975 0.293522881773965 1424 5962639 SGTC_807 1315-0151 48 µM 0.542750504817827 0.288841211821444 no 976 0.293650797821176 1484 4011080 SGTC_1504 k297-0033 30 µM 0.542646593387822 0.288877773849444 no 977 0.293686576047695 1330 4388117 SGTC_879 0831-1030 162 µM 0.541712883540397 0.289206404448988 no 978 0.29400815649615 1417 1549252 SGTC_793 0488-0545 106 µM 0.541626853312827 0.2892366926803 no 979 0.29403779448843 1381 292548 SGTC_1216 1165-0504 9.65 µM 0.5402522514277 0.289720844003818 no 980 0.294511541307272 1455 6304004 SGTC_2970 9090938 41.86 µM 0.539891347668646 0.289848021655465 no 981 0.294635982594481 1496 17217104 SGTC_1792 st045773 43.6 µM 0.539017120142145 0.290156196223689 no 982 0.294937520785611 1406 2919270 SGTC_930 2810-3379 265 µM 0.536255985249806 0.291130532689796 no 983 0.295890822813406 1574 1015764 SGTC_2142 5622915 118.518 µM 0.535023452092295 0.291565955966009 no 984 0.296316820227372 1413 5322196 SGTC_1683 st010134 710 nM 0.532974493809628 0.292290473137185 no 985 0.29702561829879 1409 3818134 SGTC_1786 berberine 21.6 µM 0.532824368799412 0.292343590653759 no 986 0.297077581661793 1391 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_512 prima-1 270 µM 0.532499241006426 0.292458643373066 no 987 0.29719013367773 1497 322968 A re-activator of the apoptotic function of mutant p53. SGTC_1407 3909-7909 12.3 µM 0.53200001061467 0.292635346603592 no 988 0.297362994076184 1409 4411780 SGTC_3289 9119912 71.43 µM 0.531651350729101 0.292758784620015 no 989 0.297483746104853 1453 17014829 SGTC_705 1124-0212 310 µM 0.531217271821544 0.292912497792086 no 990 0.29763411274506 1510 9554485 SGTC_462 ag-879 158 µM 0.527538884818945 0.294216565009894 no 991 0.29890971041268 1511 6809654 Ag-879 is a 5-Lipoxygenase inhibitor. SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM 0.527438617811006 0.29425214934082 no 992 0.298944515932236 1670 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W SGTC_1269 0831-0796 3.05 µM 0.52719770580852 0.294337656102492 no 993 0.299028150838757 1504 927758 SGTC_1041 0206-0046 107 µM 0.527032287815615 0.294396374460978 no 994 0.299085583429025 1464 50494 SGTC_194 1486-1323 56.904 µM 0.526552818352268 0.294566602092165 no 995 0.299252081957404 1407 5178754 SGTC_3039 9090270 49.47 µM 0.526507505981641 0.294582691841721 no 996 0.29926781911337 1469 17173750 SGTC_1866 st057638 64 µM 0.525873442889309 0.294807880747944 no 997 0.299488070973693 1446 688802 SGTC_953 1188-0045 9.7 µM 0.52551900597779 0.294933794368779 no 998 0.299611222259841 1501 6144426 SGTC_1748 st037455 53.6035 µM 0.525274706319599 0.295020596183321 no 999 0.299696119035619 1484 580690 SGTC_3100 9120536 49.47 µM 0.523993839523984 0.295475891889259 no 1000 0.300141412336827 1411 16421196 SGTC_2456 5770359 74.46 µM 0.52327154751696 0.295732779541077 no 1001 0.300392648993739 1525 3118787 SGTC_2413 inermin 26.06 µM 0.522674975528008 0.295945031438109 no 1002 0.300600227759097 1594 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1 SGTC_367 0335-0881 7.1 µM 0.521360154661521 0.29641307293148 no 1003 0.301057951564569 1520 23828853 SGTC_1816 st051957 91.6 µM 0.518178726216786 0.297546978773701 no 1004 0.30216678811824 1458 674121 SGTC_876 0720-0963 56.8 µM 0.517547220975265 0.297772291459521 no 1005 0.302387107155843 1572 765861 SGTC_405 ebelactone b 50 µM 0.516929902662573 0.29799261762948 no 1006 0.302602546280403 1443 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).  SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM 0.516237362208856 0.298239879620306 no 1007 0.302844319162262 1462 756377 SGTC_1942 st076330 65.2 µM 0.515546847963894 0.298486511158507 no 1008 0.303085470748121 1475 24208414 SGTC_2763 lisinopril 49.32 µM 0.515424440950145 0.298530241052683 no 1009 0.303128228495826 1429 5362119 A lysine-analog of enalapril and an ACE inhibitor. SGTC_2808 7946468 45.46 µM 0.514186377945256 0.298972702654542 no 1010 0.303560845344179 1503 2970879 SGTC_3144 9087057 49.47 µM 0.513643642485881 0.299166760467619 no 1011 0.303750580494996 1491 17249618 SGTC_2525 harmine 47.85 µM 0.513056166968439 0.299376879720231 no 1012 0.303956015964287 1527 5280953 A monoamine oxidase inhibitor SGTC_3111 9122088 49.47 µM 0.512411466999302 0.299607543129635 no 1013 0.304181533634256 1429 16876704 SGTC_246 cycloheximide 667 µM 0.510024430413843 0.300462287095947 no 1014 0.305017173175273 1407 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells. SGTC_1453 4237-0541 195 µM 0.50767543395702 0.30130448337047 no 1015 0.305840489634564 1506 739892 SGTC_2269 7935389 174.42 µM 0.506972130509409 0.301556848552171 no 1016 0.306087186714466 1424 97605 SGTC_1987 st072290 61.9 µM 0.506969689597622 0.301557724585974 no 1017 0.306088043064017 1491 54697379 SGTC_2560 caryophyllene 100 µM 0.506691381616329 0.301657615750726 no 1018 0.30618568931023 1482 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor. SGTC_3294 9122953 26.2835 µM 0.506044999350575 0.301889674675318 no 1019 0.306412530042916 1440 16459826 SGTC_71 0417-1750 47.813 µM 0.505952269501568 0.301922972372637 no 1020 0.306445078649981 1614 6811472 SGTC_2657 nystatin 74.44 µM 0.505487172319384 0.302090005675144 no 1021 0.306608352951808 1508 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_837 0091-0265 12.5 µM 0.505418549346957 0.302114654190854 no 1022 0.3066324465826 1423 759367 SGTC_2700 st077718 96.8 µM 0.505058870177235 0.302243861228215 no 1023 0.30675874415708 1465 904970 SGTC_728 3030-5151 22.5 µM 0.505015628271135 0.302259396626393 no 1024 0.306773929644988 1507 3125388 SGTC_1926 methyl fluorone black 53.6 µM 0.502732981950815 0.303079984676608 no 1025 0.307576008850387 1375 72721 Reacts with homocysteine. SGTC_3199 9111318 49.47 µM 0.498872680844756 0.304469986191226 no 1026 0.308934540505086 1534 8548020 SGTC_1772 st048439 82.2 µM 0.498609856139998 0.304564726115638 no 1027 0.309027130151563 1458 2927068 YDL195W SEC31 SGTC_1795 st049545 62.3 µM 0.498161779094632 0.304726273831002 no 1028 0.309185009708238 1513 5291882 SGTC_1311 1190-0148 100 µM 0.497758359527374 0.304871753518622 no 1029 0.30932718439309 1578 1961333 SGTC_490 phenamil 164 µM 0.496810192313233 0.305213799552521 no 1030 0.309661453536137 1548 4755 Irreversibly blocks amiloride-sensitive Na+ channels. SGTC_2523 spermine 47.74 µM 0.493953444889667 0.306245383153404 no 1031 0.31066952932105 1547 1103 A DNA binding polyamine. SGTC_255 tunicamycin 200.472 nM 0.493358238428009 0.306460508598656 no 1032 0.310879742415221 1501 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_2030 5175110 200 µM 0.492576773542845 0.306743054713415 no 1033 0.311155831389073 1555 2831986 SGTC_2491 paeonol 100 µM 0.492369124281091 0.306818151616297 no 1034 0.311229211070504 1461 11092 Increases levels of cortical cytochrome oxidase. SGTC_2584 androsterone 48.74 µM 0.489849419918623 0.30773005473045 no 1035 0.312120228478284 1511 2754130 A steroid. SGTC_969 1313-0238 134 µM 0.489831223726424 0.307736644422954 no 1036 0.312126667019845 1516 5212874 SGTC_1102 cgs 12066b 26.1 µM 0.487863361235741 0.308449665186 no 1037 0.312823313938087 1490 6438352 A 5-HT1B full agonist. SGTC_1908 st060353 56.5 µM 0.487546797720055 0.308564434057509 no 1038 0.312935443751031 1668 4227716 SGTC_1578 josamycin 24.2 µM 0.485929084667009 0.309151221483734 no 1039 0.313508723151109 1439 5282165 A P450 substrate. SGTC_2355 9061122 103.12 µM 0.484631840126515 0.309622118583594 no 1040 0.313968761824856 1581 5302957 SGTC_2660 2',4'-dihydroxychalcone 17.14 µM 0.484355370489043 0.309722516938701 no 1041 0.314066842998889 1531 5357218 A potent inhibitor of glutathione S-transferases. SGTC_1012 4112-3522 18 µM 0.483862146378532 0.309901663683775 no 1042 0.314241853236003 1589 3112398 SGTC_1320 1313-0481 95.3 µM 0.483721098700025 0.309952902719902 no 1043 0.314291908730395 1551 6813365 YLR208W SEC13 SGTC_1886 st057356 49.9 µM 0.483512598593542 0.310028652269975 no 1044 0.314365908234301 1449 24207747 SGTC_1924 st058459 75.1 µM 0.483470002956763 0.310044128555453 no 1045 0.314381026918949 1484 688683 SGTC_2432 5630864 12.22 µM 0.482716519191327 0.310317947646799 no 1046 0.314648516167048 1478 5714970 SGTC_1455 4262-0120 131 µM 0.482379185405778 0.310440570221622 no 1047 0.314768302326675 1577 1529587 SGTC_2866 9034245 58.44 µM 0.481934282975007 0.310602326773937 no 1048 0.314926315578803 1599 6462273 SGTC_2570 licareol 100 µM 0.47985807638928 0.311357672813054 no 1049 0.315664156694965 1478 443158 SGTC_2701 st077767 14.721 µM 0.478896436094564 0.311707797329225 no 1050 0.316006153237322 1477 5721188 SGTC_2546 rhodinyl acetate 100 µM 0.478475489751503 0.311861113680036 no 1051 0.316155907650962 1570 6708682 SGTC_1213 1315-0166 115 µM 0.476783194604813 0.312477807334933 no 1052 0.316758256910226 1456 768401 SGTC_1895 st058434 18.3 µM 0.476302063781814 0.312653233483638 no 1053 0.316929597655299 1604 5393175 SGTC_3266 9136860 49.47 µM 0.475865287853207 0.312812524061029 no 1054 0.317085176702077 1464 4871271 YPR165W RHO1 SGTC_3340 9146634 11.102 µM 0.474870293166704 0.313175525465775 no 1055 0.317439713294645 1516 4907387 SGTC_1716 st033144 30.6155 µM 0.47438340472407 0.313353221773241 no 1056 0.31761326249983 1613 674617 SGTC_900 1112-0045 141 µM 0.473517531486585 0.313669340589066 no 1057 0.317921998159446 1440 56211 YIL048W NEO1 SGTC_1099 5-nonyloxytryptamine 2.85 µM 0.473347446012324 0.313731452626254 no 1058 0.317982658699526 1481 23581825 A 5-HT1D beta serotonin receptor agonist. SGTC_3096 9117468 49.47 µM 0.47239480468158 0.314079437003649 no 1059 0.318322505986779 1457 41316311 SGTC_1505 k297-0037 20.6 µM 0.471460734169889 0.314420798340329 no 1060 0.318655876811601 1491 4089396 SGTC_207 4185-0010 4.486 µM 0.470947454387443 0.314608446933895 no 1061 0.318839129477843 1563 3761753 SGTC_3176 9106582 49.47 µM 0.470120359690403 0.314910923046514 no 1062 0.319134514469197 1490 17018027 SGTC_1896 st058441 89 µM 0.46943443841818 0.315161864961136 no 1063 0.319379568545747 1470 688759 SGTC_1841 st054148 70 µM 0.469273876844714 0.31522061818255 no 1064 0.319436942607056 1475 675442 SGTC_516 3992-2719 87.3 µM 0.467834943511147 0.315747365916798 no 1065 0.31995131482321 1427 5350887 YDR037W KRS1 SGTC_2848 9016370 25.97 µM 0.467339119340352 0.315928958179391 no 1066 0.32012863624221 1607 7894410 SGTC_1533 dihydroergotamine mesylate 29.4 µM 0.466344756909659 0.316293270582936 no 1067 0.320484373527439 1572 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release. SGTC_352 k048-0007 5.11 µM 0.464726969308184 0.316886373285116 no 1068 0.321063496230898 1501 6811911 SGTC_1619 st003326 88.7 µM 0.464516943191731 0.316963406251258 no 1069 0.321138711674077 1607 2849032 SGTC_2766 oltipraz 83.91 µM 0.464039490504605 0.317138554926517 no 1070 0.321309726353685 1604 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40 SGTC_2965 9082772 38.63 µM 0.463854775886061 0.317206326604375 no 1071 0.321375897864895 1649 16459634 SGTC_289 k017-0060 526 µM 0.463757154573382 0.317242146279144 no 1072 0.321410871668646 1521 5512909 SGTC_1060 3448-7350 82 µM 0.462860783368444 0.31757112704765 no 1073 0.321732079530585 1643 570178 SGTC_1699 st031318 29.054 µM 0.462361443683144 0.317754454217659 no 1074 0.321911071964027 1589 5340658 SGTC_1584 6-fluoro-dl-tryptophan 90 µM 0.462070026444444 0.317861465561275 no 1075 0.322015551980308 1621 94937 An inhibitor of serotonin biosynthesis. SGTC_2072 5231554 129 µM 0.461106387175092 0.318215431889308 no 1076 0.322361139741359 1640 789545 SGTC_398 bronopol 33.3 µM 0.460694866421574 0.318366643318734 no 1077 0.322508769309758 1578 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them. SGTC_27 0485-0001 32.618 µM 0.459763724192193 0.318708898985833 no 1078 0.322842911951319 1532 2054479 SGTC_2262 9014885 67.46 µM 0.4563432086501 0.319967488333973 no 1079 0.32407159865152 1562 6457424 SGTC_2871 9038510 12.99 µM 0.45633919206643 0.319968967470912 no 1080 0.324073042582915 1679 4945164 SGTC_247 mechlorethamine 29.705 µM 0.455877665273468 0.320138947213252 no 1081 0.324238975587313 1558 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links. SGTC_2398 5228213 48.84 µM 0.453947827390271 0.32085011277853 no 1082 0.324933189274949 1695 80771 YMR134W ERG29 SGTC_2042 p-Dimethylaminoacetophenone 200 µM 0.453790016612293 0.320908296842812 no 1083 0.32498998492132 1533 75037 A free radical scavenger. SGTC_3105 9121040 49.47 µM 0.453224411365271 0.321116868864785 no 1084 0.325193578032918 1486 41448907 SGTC_811 0416-0114 265 µM 0.453067591118727 0.321174707738555 no 1085 0.325250035696475 1552 6612453 SGTC_3310 9130229 44.1445 µM 0.452226655912601 0.321484937744427 no 1086 0.325552853509436 1607 7761258 SGTC_1831 st055328 12 µM 0.448986386806845 0.322681470773271 no 1087 0.3267207384658 1646 1103068 SGTC_2124 5246320 200 µM 0.448041604997802 0.323030696741777 no 1088 0.327061585244084 1586 579342 SGTC_2475 5812728 15.03 µM 0.447247332148885 0.323324409855741 no 1089 0.327348244916378 1514 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2 SGTC_1778 st046819 58.9 µM 0.446776066519561 0.323498730632027 no 1090 0.327518376750884 1564 671715 SGTC_2661 dactinomycin 12.96 µM 0.446759231357895 0.323504958661737 no 1091 0.327524455083736 1555 45006140 An Actinomycin D Classic transcription inhibitor. SGTC_624 k048-0052 28 µM 0.446540493011259 0.323585883609736 no 1092 0.3276034346897 1557 6835531 SGTC_755 1995-0008 37.3 µM 0.446105451840338 0.323746857250726 no 1093 0.327760537437367 1557 689533 SGTC_745 0469-0705 296 µM 0.444548537959667 0.324323215500298 no 1094 0.328323022275267 1683 3486736 SGTC_1449 4112-4002 201 µM 0.44412081571981 0.324481628980913 no 1095 0.328477618825347 1496 2059539 SGTC_2740 felodipine 17.08 µM 0.442059835610957 0.325245389387608 no 1096 0.329222953791137 1665 3333 L-type calcium channel blocker SGTC_73 0327-0325 16.231 µM 0.441049320500558 0.325620135888553 no 1097 0.329588645882889 1692 53298 SGTC_497 capsazepine 133 µM 0.440991372537835 0.325641631065625 no 1098 0.329609621431491 1482 2733484 A calcium channel blocker. SGTC_298 1391-0729 10 µM 0.440088883032185 0.325976474686932 no 1099 0.329936366643625 1552 3237558 SGTC_2273 7815444 169.05 µM 0.439830227018969 0.326072467699581 no 1100 0.330030036675186 1692 2824616 SGTC_3299 9121982 43.1275 µM 0.439527756608534 0.326184735832637 no 1101 0.330139587227944 1540 17594604 YPL160W CDC60 SGTC_1679 SEC14.276 6.7 µM 0.438274593488478 0.32665004092962 no 1102 0.330593620473412 1706 1005053 YMR079W SEC14 SGTC_283 0987-0079 11.7 µM 0.436656472090543 0.32725125569814 no 1103 0.331180250566925 1637 411556 SGTC_202 3594-0513 34.79 µM 0.434411081172346 0.328086275859777 no 1104 0.33199497617119 1583 708429 SGTC_383 2324-0395 7.37 µM 0.433603048995659 0.328386979001036 no 1105 0.332288360149962 1641 3146421 SGTC_676 falcarinol 140 µM 0.433176200169793 0.328545872506534 no 1106 0.332443383862609 1692 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer. SGTC_974 1326-0144 138 µM 0.432938757401331 0.328634273461754 no 1107 0.332529631157726 1556 5411856 SGTC_1996 st072960 66.8 µM 0.43278509393652 0.328691488137257 no 1108 0.332585451684238 1631 1719405 SGTC_1833 st055984 71 µM 0.431724810936097 0.329086380685097 no 1109 0.332970716291484 1585 676288 SGTC_3 0833-0587 95.581 µM 0.430079524173176 0.32969953009194 no 1110 0.333568897066674 1566 5382644 SGTC_934 2950-0684 338 µM 0.429568645108164 0.329890012777077 no 1111 0.333754724782389 1694 1121253 SGTC_3177 9107506 49.47 µM 0.428128733669958 0.330427125063257 no 1112 0.334278699108177 1656 8897194 SGTC_1319 1306-0155 43.7 µM 0.42590710476199 0.331256517075515 no 1113 0.335087768829228 1615 3122360 SGTC_1149 3909-7961 23.3 µM 0.425851836349941 0.331277160792666 no 1114 0.335107906180032 1546 735261 SGTC_1588 farnesol 29.9 µM 0.425164543975951 0.331533919314928 no 1115 0.335358364526013 1563 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_3116 9124943 49.47 µM 0.424406507960321 0.331817198060154 no 1116 0.335634687664964 1502 41905195 YPL160W CDC60 SGTC_2127 5253358 187.912 µM 0.423971152959422 0.331979934112437 no 1117 0.335793425685012 1535 20612 SGTC_60 0986-0278 202 µM 0.422981917396192 0.332349828979858 no 1118 0.336154227107912 1421 3110598 SGTC_863 0466-0191 129 µM 0.422312526233132 0.332600220352056 no 1119 0.336398458157507 1679 765160 YPR165W RHO1 SGTC_1422 4031-0024 15.5 µM 0.422293888190055 0.332607193137637 no 1120 0.336405259338591 1601 782427 SGTC_801 0866-0028 10.1 µM 0.418836957337692 0.333901484748264 no 1121 0.337667646597181 1612 6849771 SGTC_622 1348-1566 26.3 µM 0.416986536838899 0.334595105131965 no 1122 0.338344127639309 1687 7340407 SGTC_3146 9095609 49.47 µM 0.416680014387142 0.334710058059188 no 1123 0.338456237296962 1666 17173999 SGTC_628 1636-0253 16 µM 0.416464707207057 0.334790812438173 no 1124 0.338534993807858 1673 4456143 SGTC_481 bay k-8644 50 µM 0.415081757304262 0.335309691794358 no 1125 0.339041026774172 1558 2303 A calcium channel antagonist. SGTC_2315 7733312 200 µM 0.414636570697696 0.33547679163137 no 1126 0.339203986148395 1565 726316 SGTC_80 0159-0065 512.242 µM 0.413096021893008 0.33605528433973 no 1127 0.339768131947898 1624 1548079 SGTC_1168 k815-0004 80.5 µM 0.41306360686773 0.336067460709969 no 1128 0.339780006125093 1579 642433 SGTC_180 1486-1293 102.781 µM 0.412659739579783 0.336219183715306 no 1129 0.339927962935465 1771 4140536 SGTC_1280 0880-0253 10.1 µM 0.411881580645882 0.336511594100028 no 1130 0.340213111033004 1586 6836607 SGTC_67 0335-0847 266 µM 0.41118745871252 0.336772509190765 no 1131 0.340467541799398 1830 4552207 YOR254C SEC63 SGTC_907 3448-6986 75.5 µM 0.410789484109306 0.33692214023198 no 1132 0.340613452368222 1694 590582 SGTC_2953 9074162 66.49 µM 0.410526445070042 0.337021052183049 no 1133 0.340709904220324 1762 16451992 SGTC_2705 st078069 42.8 µM 0.410170364743495 0.337154968891598 no 1134 0.340840489291067 1588 1530061 SGTC_3048 9093155 49.47 µM 0.40919246216772 0.33752285016133 no 1135 0.341199212847 1644 25236002 SGTC_1615 st002656 86.5 µM 0.408676973401846 0.337716836589752 no 1136 0.341388367162569 1591 1584458 SGTC_2462 5162487 171.77 µM 0.407783075800856 0.338053326337464 no 1137 0.341716469902519 1655 2259986 SGTC_1048 3161-0300 24.5 µM 0.40713849762699 0.338296045139878 no 1138 0.341953134849448 1564 2165101 SGTC_3103 9120822 49.47 µM 0.406224365590351 0.338640380889594 no 1139 0.342288876365208 1707 17141819 SGTC_164 4100-3994 89.624 µM 0.405692294218144 0.338840863962547 no 1140 0.342484352443988 1753 4615967 SGTC_250 brefeldin a 552.239 µM 0.404847359881475 0.339159326777268 no 1141 0.342794856989883 1590 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.  SGTC_609 0986-0026 86.3 µM 0.403299146438642 0.339743159512291 no 1142 0.343364084794653 1677 2848610 SGTC_2466 5983409 37.09 µM 0.401510217083405 0.340418245456383 no 1143 0.344022258696818 1612 2879657 SGTC_1411 3909-8223 150 µM 0.40128303492123 0.340504013554071 no 1144 0.344105876295754 1732 X1411 SGTC_3164 9100705 49.47 µM 0.399825153403193 0.341054603823037 no 1145 0.34464265142184 1703 17174235 SGTC_1143 3454-2408 5.08 µM 0.398954388720792 0.341383622456125 no 1146 0.344963406269378 1614 X1143 SGTC_2981 9013952 38.96 µM 0.396852880718078 0.342178174058687 no 1147 0.345737976336398 1521 2996344 SGTC_1140 3229-1848 2.98 µM 0.396685823942888 0.342241366001319 no 1148 0.345799577590687 1714 2849525 SGTC_818 4072-2707 53.5 µM 0.396478335373574 0.342319858078566 no 1149 0.345876093527451 1559 882871 SGTC_2352 9027995 87.8 µM 0.394896816962369 0.342918363650604 no 1150 0.346459519592468 1683 2997347 SGTC_3192 9110362 49.47 µM 0.393271666703429 0.343533792036453 no 1151 0.347059421249321 1669 16649480 SGTC_1383 3049-0032 20.7 µM 0.392197326524098 0.343940862046992 no 1152 0.347456209672352 1744 712864 SGTC_198 3454-2873 16.191 µM 0.386729440152943 0.346015452513041 no 1153 0.349478259341131 1673 710957 SGTC_1211 1056-0033 32.3 µM 0.385901328201017 0.346330054731097 no 1154 0.349784873457598 1737 6741922 SGTC_637 1181-0519 7.26 µM 0.384650625425293 0.346805401464783 no 1155 0.350248140435958 1631 6252091 YGR060W ERG25 SGTC_1680 diphenhydramine 100 µM 0.383741466485048 0.347151091250565 no 1156 0.350585037712742 1641 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1 SGTC_1985 st071382 65.5 µM 0.381092734840802 0.348158943650277 no 1157 0.351567219074462 1655 6123237 SGTC_1141 3253-0389 52.6 µM 0.38033107348349 0.348448957691643 no 1158 0.351849836099596 1736 5402031 SGTC_661 1304-0007 33.6 µM 0.379812231496199 0.348646565351781 no 1159 0.352042401070392 1625 3117130 SGTC_1017 4239-0030 168 µM 0.379663073566721 0.348703381675702 no 1160 0.352097767131886 1578 1149593 SGTC_331 k048-0133 24.5 µM 0.378242801932355 0.349244552670389 no 1161 0.352625115913544 1628 6813582 SGTC_1921 5740136 50 µM 0.377560443374084 0.349504663233888 no 1162 0.3528785774032 1807 1774243 SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM 0.376879062011254 0.349764471828339 no 1163 0.353131741082387 1612 4174840 SGTC_1307 1187-1599 12.2 µM 0.376812037731395 0.349790031781091 no 1164 0.353156647116852 1647 1538471 SGTC_1133 3473-0247 50 µM 0.37659078112251 0.349874413625779 no 1165 0.353238869917457 1588 711311 SGTC_1172 0370-0043 85 µM 0.376259541501415 0.350000754153442 no 1166 0.353361977121838 1704 376585 SGTC_780 0109-0199 192 µM 0.375442729137922 0.350312371475526 no 1167 0.353665615913065 1794 610414 SGTC_2586 curcumin 80 µM 0.374759079925784 0.350573263994743 no 1168 0.35391982473023 1756 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40 SGTC_1960 st011366 51.8 µM 0.374354670492515 0.350727626914877 no 1169 0.354070231413627 1648 3972846 SGTC_881 0833-0569 170 µM 0.373390892341372 0.35109559996997 no 1170 0.354428768512975 1594 5418700 SGTC_10 0279-0212 42.575 µM 0.373383204647362 0.351098535713853 no 1171 0.354431628947064 1640 39851 YBR002C RER2 SGTC_3140 9094243 49.47 µM 0.370368474391026 0.352250471548649 no 1172 0.355553980044731 1706 19291112 SGTC_1079 idarubicin 2.36 µM 0.369140061538616 0.352720240811197 no 1173 0.356011664760898 1720 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_3324 9138759 60.749 µM 0.367375947242175 0.353395265709627 no 1174 0.356669305244287 1693 45595710 SGTC_1571 st070080 73.4 µM 0.366719301846222 0.353646644023029 no 1175 0.356914203688819 1766 4315245 SGTC_296 1222-0039 74.9 µM 0.36640797335431 0.353765849737856 no 1176 0.357030335472436 1624 5984176 SGTC_337 1315-0038 354 µM 0.365804153854544 0.353997089279867 no 1177 0.357255610035953 1672 1626437 SGTC_517 1365-0151 113 µM 0.365701267355706 0.354036496207239 no 1178 0.357294000165033 1695 768657 SGTC_1004 4084-0029 199 µM 0.365480798733575 0.354120943950003 no 1179 0.357376268677904 1801 716894 YLR208W SEC13 SGTC_851 0394-0702 453 µM 0.365353240682894 0.354169806739661 no 1180 0.357423870366128 1796 762646 SGTC_2655 perillic acid 100 µM 0.361607639713623 0.355605675870554 no 1181 0.358822627416051 1664 5702197 An apoptosis inducer. SGTC_945 3381-0768 11.3 µM 0.357861148299288 0.357043939075934 no 1182 0.360223613479445 1756 1126236 YIL048W NEO1 SGTC_2708 st078559 56 µM 0.357323296869803 0.357250585543019 no 1183 0.360424895643738 1676 17250902 SGTC_93 0109-0045 59.227 µM 0.356593239797087 0.357531145814406 no 1184 0.36069816953519 1745 88733 SGTC_1345 1488-0192 31.4 µM 0.355078176564641 0.358113628837471 no 1185 0.361265512678851 1798 658348 SGTC_3007 9078383 71.4286 µM 0.35503828397957 0.358128970458899 no 1186 0.361280455317225 1673 6496995 SGTC_2516 gossypol 71.55 µM 0.355030267700263 0.358132053333195 no 1187 0.361283458015129 1824 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_359 0081-0058 15.9 µM 0.352439335894621 0.359128948966132 no 1188 0.362254403115667 1835 3494159 SGTC_1221 2958-7315 257 µM 0.351028715347687 0.359672108131129 no 1189 0.362783402872675 1725 4562705 SGTC_3293 9120939 62.045 µM 0.349892465374774 0.36010982723173 no 1190 0.363209700913742 1755 934087 SGTC_2014 4013930 200 µM 0.349566667932838 0.360235368488125 no 1191 0.363331964825869 1777 64556 SGTC_1397 3532-0190 20.1 µM 0.349345279453868 0.360320685886986 no 1192 0.363415054522617 1728 5322280 SGTC_2411 st077133 39.94 µM 0.349321322689539 0.360329918622051 no 1193 0.363424046163082 1847 1403142 YNL221C POP1 SGTC_562 3772-2733 112 µM 0.348566060919123 0.360621031877361 no 1194 0.363707555484055 1795 2876874 YIL048W NEO1 SGTC_2157 5649910 96.377 µM 0.348312923725686 0.360718620892421 no 1195 0.363802594550504 1650 2858091 SGTC_2783 7738165 71.43 µM 0.348312265670778 0.36071887459644 no 1196 0.363802841624781 1587 17201110 SGTC_1032 k061-1018 98.7 µM 0.347727550472398 0.360944327712624 no 1197 0.364022402035512 1853 4005393 SGTC_3142 9086498 49.47 µM 0.347283074453891 0.361115740068054 no 1198 0.36418933254089 1844 25236367 SGTC_2683 piperine 63.03 µM 0.346952907519925 0.361243087136114 no 1199 0.364313349013452 1713 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_1840 st055363 71 µM 0.344956406589289 0.362013474903336 no 1200 0.365063571942322 1632 676033 SGTC_2172 5754775 163.918 µM 0.343008231028666 0.362765754745221 no 1201 0.365796133967417 1651 2263357 SGTC_2549 cedrol 20.94 µM 0.339955057123975 0.363945790346719 no 1202 0.366945186756244 1797 6708665 A sedative which affects the nervous system. SGTC_3229 9132204 49.47 µM 0.339461140652391 0.364136808100809 no 1203 0.36713118311159 1764 17682924 SGTC_975 1335-0046 28.5 µM 0.337143633359997 0.36503353330215 no 1204 0.36800431311477 1624 16486740 SGTC_1854 st056233 32.9 µM 0.336947647877549 0.365109400929085 no 1205 0.368078182773437 1845 5393174 SGTC_814 3342-0569 96 µM 0.336545530647899 0.365265080415932 no 1206 0.3682297616293 1732 4346283 SGTC_821 1114-0266 29.2 µM 0.335949615218298 0.365495829610489 no 1207 0.368454430806997 1703 3123235 SGTC_226 1,3-diallylurea 8.28947 mM 0.335095144236932 0.365826781117465 no 1208 0.368776657833494 1754 74537 YKL182W FAS1 SGTC_812 4251-0442 148 µM 0.332913499949446 0.366672222520503 no 1209 0.369599789341396 1837 5723007 SGTC_2131 toluylene red 5.2905 µM 0.332046250158087 0.367008483403142 no 1210 0.369927167859946 1664 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain. SGTC_1459 k035-0031 35.7 µM 0.331623799598661 0.367172318172073 no 1211 0.370086673078381 1630 3877128 YMR208W ERG12 SGTC_2951 9072950 58.06 µM 0.33121461036412 0.367331032996686 no 1212 0.37024119250716 1799 16488155 SGTC_644 1498-1197 63.3 µM 0.331175217060956 0.36734631392379 no 1213 0.370256069445667 1787 6741615 SGTC_284 0988-0104 32.6 µM 0.330694324163041 0.367532872440721 no 1214 0.370437694991447 1804 4666532 SGTC_2606 farnesol 9.78 µM 0.33048749425111 0.367613120053171 no 1215 0.370515820222427 1829 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_394 menadione 8.33 µM 0.32982413429566 0.367870535024735 no 1216 0.370766425169128 1831 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_1061 3448-9325 110 µM 0.328223983491568 0.368491713128221 no 1217 0.371371157609165 1811 723482 SGTC_1873 rapamycin 2 nM 0.326721733761717 0.369075199050469 no 1218 0.37193918022223 1710 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1 SGTC_1719 st032227 49.2 µM 0.325507651625377 0.369546978958205 no 1219 0.372398446258768 1669 3125804 SGTC_1183 1254-0324 198 µM 0.324791649931869 0.369825302050999 no 1220 0.372669382313377 1824 5799357 SGTC_1159 4092-0538 61.2 µM 0.322962420868504 0.370536666598403 no 1221 0.373361851024948 1769 717301 SGTC_2994 9053520 71.4286 µM 0.322406239933299 0.37075304639639 no 1222 0.373572478811523 1846 4647384 SGTC_1627 st003713 25.6 µM 0.321705487674059 0.371025729244808 no 1223 0.373837910064458 1719 16195070 YER133W GLC7 SGTC_2693 st077581 40.7 µM 0.321552174799628 0.371085396332063 no 1224 0.373895989966137 1789 25238761 SGTC_155 k072-0202 43.6 µM 0.321370037178818 0.37115628560922 no 1225 0.373964993340268 1855 5857737 SGTC_1993 st073995 70.8 µM 0.320618570022472 0.371448808257351 no 1226 0.374249731573502 1774 3098394 SGTC_3287 9117173 37.0625 µM 0.320087433844205 0.371655607754859 no 1227 0.374451025644356 1788 2789709 SGTC_3298 9116858 71.43 µM 0.320019101577456 0.371682215822871 no 1228 0.374476925217855 1849 2506942 SGTC_909 3448-9333 149 µM 0.318873038100385 0.372128575546303 no 1229 0.374911395178881 1673 3344074 SGTC_2285 7945142 200 µM 0.318613269296672 0.372229772157661 no 1230 0.375009895014979 1730 2970608 SGTC_1986 st071812 45 µM 0.318469893900287 0.372285629850826 no 1231 0.375064263976815 1754 11838594 SGTC_862 0452-0056 10.2 µM 0.31564079590708 0.373388367809624 no 1232 0.376137584409411 1798 1575396 YLR359W | YHR072W ADE13 | ERG7 SGTC_2490 carminic acid 95.39 µM 0.312998121482437 0.37441937848941 no 1233 0.377141044669853 1766 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_79 0052-0007 94.094 µM 0.309792062681687 0.375671393370217 no 1234 0.378359543974256 1857 2801472 SGTC_2948 9070189 9.45 µM 0.307786665749203 0.376455198495133 no 1235 0.379122334284632 1899 6473636 YDL196W YDL196W SGTC_1251 0490-5699 265 µM 0.307647010801861 0.376509801354073 no 1236 0.37917547223442 1909 3883818 SGTC_1664 st014217 9.02 µM 0.307643390261833 0.376511216960394 no 1237 0.379176849860624 1831 3982782 SGTC_1968 st069590 43.6 µM 0.306929435113111 0.37679040095903 no 1238 0.379448541874085 1854 6384066 SGTC_120 rhodamine 6G 52.259 µM 0.306731015603026 0.376868002089814 no 1239 0.379524059991924 1724 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase SGTC_389 tpck 16.7 µM 0.304876243935097 0.377593636575853 no 1240 0.38023020476979 1777 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.  SGTC_2894 9048625 32.47 µM 0.304703693078052 0.377661164934802 no 1241 0.380295918311575 1890 4092861 SGTC_3231 9132313 49.47 µM 0.304101558843071 0.377896841475942 no 1242 0.380525259631953 1793 4905967 SGTC_2066 5222451 176 µM 0.302704456295472 0.378443845151397 no 1243 0.381057550701322 1768 2281147 SGTC_457 grayanotoxin iii 135 µM 0.301396432639177 0.378956192912694 no 1244 0.38155610713213 1826 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity. SGTC_2436 5633522 8.09 µM 0.301138719712693 0.379057163176075 no 1245 0.381654358253629 1912 5724242 SGTC_2739 tacrine 100.86 µM 0.300785941777432 0.379195392676432 no 1246 0.381788864559294 1773 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders. SGTC_208 k072-0098 12.366 µM 0.300744520300278 0.379211623928814 no 1247 0.381804658575115 1791 5948901 SGTC_699 0375-0592 111 µM 0.299217482350275 0.379810151243616 no 1248 0.382387055510815 1933 762578 SGTC_2669 eugenol 100 µM 0.299144559469832 0.379838740812659 no 1249 0.382414874233598 1888 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism. SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM 0.299001049479899 0.379895006124767 no 1250 0.382469622398144 1803 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_2521 angolensin 13.4 µM 0.296347011469965 0.38093601992942 no 1251 0.383482543708717 1819 821428 A flavenoid. SGTC_1837 st055472 66.5 µM 0.293298924351037 0.382132658362616 no 1252 0.384646837880016 1841 676091 SGTC_2908 7930301 100 µM 0.293119477634484 0.382203141986092 no 1253 0.384715414658265 1746 2223178 SGTC_737 1950-0117 57.9 µM 0.292564283063118 0.382421237700462 no 1254 0.384927608860356 1913 5393513 SGTC_1130 3454-2858 15.9 µM 0.292413288816807 0.382480558852789 no 1255 0.384985324509544 1713 715628 YIL048W NEO1 SGTC_560 2332-1943 155 µM 0.290336273582796 0.383296835734908 no 1256 0.385779495530129 1793 21177716 SGTC_3097 9117246 49.47 µM 0.289215492958148 0.383737523428954 no 1257 0.386208238282989 1765 16423892 SGTC_2725 haloperidol 53.21 µM 0.286092475862674 0.384966276546551 no 1258 0.387403647106982 1802 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_1327 1436-0082 2.18 µM 0.285949374748186 0.385022607567895 no 1259 0.387458448135144 1808 15992205 SGTC_1994 st072947 40.9 µM 0.285585544796002 0.385165838291986 no 1260 0.387597788071849 1848 5286565 YDL195W SEC31 SGTC_3247 9135149 49.47 µM 0.285129343776323 0.385345455325377 no 1261 0.387772524824067 1820 8934436 YOR116C RPO31 SGTC_2602 kawain 100 µM 0.284664022336355 0.385528688621622 no 1262 0.387950778348946 1875 5369129 SGTC_3136 9095672 49.47 µM 0.28398350625731 0.385796706808838 no 1263 0.388211510306661 1955 17217380 SGTC_3246 9135460 32.98 µM 0.283321450809814 0.386057506692333 no 1264 0.388465217646076 1882 41446951 SGTC_2091 4-phenylthiadiazole 200 µM 0.282034421768267 0.386564646279961 no 1265 0.388958558226537 1800 270010 SGTC_1695 st026914 34.495 µM 0.280773740015149 0.387061591914966 no 1266 0.389441973084885 1803 3289191 SGTC_1043 0916-0009 19.3 µM 0.280657579785933 0.387107390214426 no 1267 0.389486523940068 1983 3101130 SGTC_1575 cyproterone acetate 48 µM 0.280594744371503 0.387132164883328 no 1268 0.389510623770002 1748 9880 An androgen receptor antagonist and liver toxin. SGTC_2648 atorvastatin 78.68 µM 0.278184116360478 0.388082970574667 no 1269 0.390435513569457 1900 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11 SGTC_2027 5150920 200 µM 0.276864070907658 0.388603910880551 no 1270 0.390942240893976 1890 786715 SGTC_1752 st044819 83.042 µM 0.276622526329256 0.388699255306164 no 1271 0.391034982953257 1770 441209 YML126C ERG13 SGTC_601 0986-0029 62.9 µM 0.276565033643201 0.38872195027138 no 1272 0.391057058425695 1816 24747981 SGTC_9 0092-0002 10.449 µM 0.275762194706913 0.389038906783876 no 1273 0.39136536121661 1841 759368 SGTC_951 1171-0579 82.7 µM 0.275704496043078 0.389061688754624 no 1274 0.391387521043365 1768 1616050 YPR165W | YDR526C RHO1 | YDR526C SGTC_3118 9124250 49.47 µM 0.274114548671593 0.389689619732958 no 1275 0.391998296836809 1802 1504786 SGTC_1507 4075-3230 155 µM 0.273287005442883 0.390016562268226 no 1276 0.39231630171686 1947 659771 SGTC_1093 fluphenazine 7.97 µM 0.27303563424199 0.390115888436899 no 1277 0.392412911851165 1850 6602611 An atypical antipsychotic. SGTC_2616 abietic acid 100 µM 0.273007787982467 0.390126891977655 no 1278 0.392423614483125 1998 6708678 Abietic acid is an inhibitor of 5α-reductase. SGTC_2762 leflunomide 42.06 µM 0.272792398199036 0.390212006930147 no 1279 0.39250640169202 1819 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1 SGTC_1697 st025554 27.742 µM 0.272418481481468 0.390359779005706 no 1280 0.392650131857489 1796 1269519 SGTC_2389 9091542 195.52 µM 0.271728243981821 0.390632602810526 no 1281 0.392915491283562 1803 3626624 YOL127W RPL25 SGTC_3335 9143315 29.6265 µM 0.269770456092583 0.391406732136697 no 1282 0.393668426507738 1808 4899691 SGTC_3216 9129716 49.47 µM 0.268969889140881 0.39172340861878 no 1283 0.393976427025302 1788 8056934 SGTC_3321 9137793 26.8275 µM 0.268598796201318 0.391870224450884 no 1284 0.39411921937747 1865 4904192 SGTC_1138 3761-0006 1.03 µM 0.267912603144483 0.392141744173837 no 1285 0.394383296159128 1869 12061087 SGTC_2215 7188065 200 µM 0.267619823287373 0.392257610226909 no 1286 0.394495985301644 1920 940217 SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM 0.26690013581385 0.392542463254033 no 1287 0.394773026036231 1899 616764 SGTC_3076 9116187 49.47 µM 0.266261977747672 0.392795095026892 no 1288 0.39501872688313 1962 27241210 SGTC_1707 st032323 6.317 µM 0.264677187366179 0.3934226714308 no 1289 0.395629076384424 1861 3132057 YMR211W DML1 SGTC_1648 st011736 69.8 µM 0.264444358016642 0.393514895143058 no 1290 0.395718767439466 1924 2855514 SGTC_2327 6189656 200 µM 0.263912002866047 0.393725783472745 no 1291 0.395923863250986 1927 5349088 SGTC_478 N-arachidonylglycine 10 µM 0.262177052773747 0.394413286429709 no 1292 0.396592472003674 1941 5283389 SGTC_1165 k072-0275 30.3 µM 0.261752860513026 0.394581429841997 no 1293 0.396755992025111 1939 6153523 YGL055W OLE1 SGTC_335 4077-0256 27.6 µM 0.261746371887381 0.394584001987907 no 1294 0.396758493438129 1914 3121989 SGTC_2231 micatex 6.853 µM 0.261467907504642 0.394694391946254 no 1295 0.396865847512488 1883 20737 An antifungal of unknown mechanism. SGTC_2746 daunorubicin 9.88 µM 0.26140542080703 0.39471916433342 no 1296 0.3968899385672 1959 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_2938 9059746 27.26 µM 0.259762087838049 0.395370804003741 no 1297 0.397523648399594 1875 6471769 SGTC_2422 chlorphenesin carbamate 384.24 µM 0.259386392897683 0.39551982150957 no 1298 0.397668563716931 1813 2724 A muscle relaxant with antifungal properties. SGTC_1281 0884-0031 11.8 µM 0.257118883450118 0.396419541322104 no 1299 0.398543500296099 1817 1548255 SGTC_1875 nocodazole 6 µM 0.256895482467187 0.396508214021682 no 1300 0.398629729025108 1989 4122 A microtubule depolymerizer. YJL014W CCT3 SGTC_2748 diazoxide 86.69 µM 0.256485154281265 0.396671096128293 no 1301 0.398788121155051 1920 3019 A potassium channel activatior. SGTC_2666 tannic acid 100 µM 0.256264023739406 0.396758882633311 no 1302 0.398873487395712 1890 16134267 A thiamine antagonist. SGTC_1481 3346-2004 36 µM 0.256233935407854 0.396770827789782 no 1303 0.398885103206134 1914 2770522 SGTC_534 k292-0788 63.4 µM 0.256171479711515 0.396795623194857 no 1304 0.398909214949532 2017 4146317 SGTC_3219 9131112 49.47 µM 0.255205241169923 0.397179280638631 no 1305 0.399282291602625 1924 17612988 YMR079W SEC14 SGTC_2405 ticlatone 3.52 µM 0.253881538118488 0.397705035450844 no 1306 0.399793539022099 1619 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W SGTC_634 1611-4317 11.2 µM 0.253675403944129 0.397786925572896 no 1307 0.399873168710849 1995 2843522 SGTC_2454 5-benzylidenerhodanine 10.36 µM 0.253261640975324 0.397951313168778 no 1308 0.400033018025001 1995 1273210 SGTC_1428 4049-0204 61.7 µM 0.252592202074978 0.3982173189049 no 1309 0.40029167825181 1951 X1428 SGTC_1388 3346-4487 254 µM 0.251737635686696 0.398556954935654 no 1310 0.400621932252426 1915 3345614 SGTC_1789 tunicamycin 25 nM 0.250383018005639 0.399095487055081 no 1311 0.40114558056019 1980 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_1532 4',5'-dihydroxyflavone 78.7 µM 0.248492731477507 0.399847296737021 no 1312 0.401876596598139 1891 165521 SGTC_116 0155-0182 31.788 µM 0.248151780450859 0.399982940285967 no 1313 0.402008486611211 1840 771486 SGTC_1517 deoxycholic acid methyl ester 49.2 µM 0.247955424086586 0.4000610639449 no 1314 0.402084448166731 1825 229346 A bile salt which induces apoptosis. SGTC_2551 apiole 73.87 µM 0.246274347297666 0.400730071822739 no 1315 0.402734933197456 1925 10659 A possible DNA adduct former. SGTC_2972 9093619 59.92 µM 0.245407239314012 0.401075263494647 no 1316 0.403070562104797 1780 25236256 SGTC_329 k048-0121 21.3 µM 0.245258463791641 0.401134498111691 no 1317 0.403128155389194 1865 6832902 SGTC_1472 k841-0093 193 µM 0.244636769660784 0.401382048712897 no 1318 0.403368845438899 1976 X1472 SGTC_586 0957-0265 8.15 µM 0.244520513967161 0.401428344630398 no 1319 0.403413858114536 1999 6752309 YPR165W | YPR107C RHO1 | YTH1 SGTC_1915 st067105 30.6 µM 0.244353576253115 0.401494825812783 no 1320 0.403478496439738 1879 69751 YOR207C | YOR116C RET1 | RPO31 SGTC_972 1319-0219 195 µM 0.243265836216521 0.401928076536184 no 1321 0.403899734145418 1846 23903702 SGTC_3184 9108758 49.47 µM 0.242614898439467 0.402187405055277 no 1322 0.404151869356674 1884 902885 SGTC_761 k216-0224 480 µM 0.241205960086169 0.402748862403997 no 1323 0.404697745889531 2029 1340404 SGTC_1331 1472-0049 76.2 µM 0.240823735517573 0.402901212294403 no 1324 0.404845866324763 1834 24051409 SGTC_2623 humulene 100 µM 0.237931563650076 0.404054471782918 no 1325 0.40596708706659 1833 6187145 An anti-inflammatory. SGTC_3060 1327-0027 12.5 µM 0.237501607883793 0.40422598901538 no 1326 0.406133835986295 2001 16000455 YPR107C YTH1 SGTC_844 0330-0132 15.3 µM 0.237088415340963 0.40439083643999 no 1327 0.406294099703117 1972 2828079 SGTC_2943 9068529 45.32 µM 0.236512981977847 0.40462043978891 no 1328 0.406517317419145 1956 3270634 SGTC_431 k089-0097 107 µM 0.235613549802378 0.404979387494481 no 1329 0.406866279110847 1924 5499420 SGTC_392 N-ethylmaleimide 8.33 µM 0.235562925953909 0.404999592969786 no 1330 0.406885922352377 1853 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides. SGTC_2183 6420625 130.508 µM 0.235137871948079 0.405169254581437 no 1331 0.407050862520044 1918 2897619 SGTC_324 1315-0088 19.6 µM 0.234305483802777 0.405501556466703 no 1332 0.407373914474279 1937 6787421 SGTC_443 clozapine 122 µM 0.234080798047203 0.405591266090345 no 1333 0.407461126395714 2033 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_1053 3366-3204 134 µM 0.233341489235119 0.405886482734665 no 1334 0.407748121944999 1817 3632071 YPR165W RHO1 SGTC_1254 0550-0035 264 µM 0.233259741180329 0.405919129198642 no 1335 0.407779859125908 1954 15121435 SGTC_1070 indatraline 8.81 µM 0.232720810457999 0.406134370040924 no 1336 0.407989104217863 1854 10314472 A monamine transport inhibitor. YGL099W LSG1 SGTC_464 bw-b 70c 158 µM 0.232331253160668 0.406289971049563 no 1337 0.408140369970689 1980 5353454 SGTC_1246 0422-0085 105 µM 0.232085854455795 0.406387998340926 no 1338 0.408235665730141 2017 264295 SGTC_2198 6589944 200 µM 0.23175560450387 0.406519929684184 no 1339 0.408363920368244 1943 5290268 SGTC_2787 5284540 71.43 µM 0.231624157614826 0.406572444271671 no 1340 0.408414971323166 1874 736958 SGTC_351 caspofungin 25 nM 0.230636930193615 0.406966906945291 no 1341 0.408798437412874 1918 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1 SGTC_507 nimesulide 162 µM 0.230507975904777 0.407018439694518 no 1342 0.408848533235784 2008 4495 A COX2 inhibitor. SGTC_3273 9137859 49.47 µM 0.227853768353388 0.408079471165584 no 1343 0.409879962410436 2045 2377234 SGTC_2140 5586273 200 µM 0.227831972137236 0.408088187103904 no 1344 0.40988843504633 1960 854421 SGTC_3086 9117350 49.47 µM 0.226752585064775 0.408519872553328 no 1345 0.410308067477542 1931 2679265 SGTC_319 1348-1596 45.5 µM 0.226666753845385 0.408554204296233 no 1346 0.410341440425555 2018 5380505 SGTC_13 0199-0087 65 µM 0.225808118473112 0.408897689578826 no 1347 0.410675331261627 1991 4589825 SGTC_3019 9081971 49.47 µM 0.225754676316104 0.408919070695363 no 1348 0.410696115038796 2007 16451803 SGTC_3341 9147222 25.867 µM 0.225699291952515 0.408941229135106 no 1349 0.410717654409136 1913 1939759 SGTC_602 3130-1533 38.1 µM 0.224913935752663 0.409255469470481 no 1350 0.411023113933466 2003 720941 SGTC_691 1548-0686 185 µM 0.224537884522342 0.409405957479837 no 1351 0.411169395891516 1842 46495133 SGTC_2484 5809818 12.04 µM 0.224292681476058 0.409504089914813 no 1352 0.411264785245851 1887 2870548 SGTC_2575 plumbagin 510 nM 0.224187096377456 0.409546347755059 no 1353 0.41130586177749 1826 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_1496 4469-0713 57.4 µM 0.222519010413706 0.410214097297827 no 1354 0.411954938016959 1990 746691 SGTC_2241 6772625 37.8075 µM 0.222077462849606 0.410390896356019 no 1355 0.412126790929836 2047 2285411 SGTC_3250 9135583 49.47 µM 0.219531074213791 0.411410844356266 no 1356 0.413118188228099 2038 7699353 SGTC_2348 9022543 33.42 µM 0.219481621682103 0.411430658364778 no 1357 0.413137447318965 1928 3162678 YDL140C RPO21 SGTC_866 0495-0101 262 µM 0.219126384835409 0.411572996762098 no 1358 0.41327579903084 1822 635694 SGTC_3323 9138564 53.9225 µM 0.218549592044979 0.411804134285296 no 1359 0.413500461582864 2035 43912313 YNL103W MET4 SGTC_2650 prasterone 100 µM 0.218380758978234 0.411871796363239 no 1360 0.413566227939169 1963 16759247 A steroid and weak partial agonist of the androgen receptor. SGTC_3101 9120531 49.47 µM 0.21817360207694 0.411954820803075 no 1361 0.413646926075784 2022 24824904 SGTC_1998 st075797 76.8 µM 0.217227959777229 0.41233386577259 no 1362 0.414015348066516 2030 24208315 SGTC_2010 4012422 159 µM 0.216748696223205 0.412526001838594 no 1363 0.414202097941335 1940 952393 SGTC_1734 st037168 69.4 µM 0.21663830528862 0.412570260376693 no 1364 0.414245115632171 1854 708907 SGTC_1511 0906-3109 28.5 µM 0.215852681357602 0.412885269100817 no 1365 0.414551291174208 1990 2882180 SGTC_3026 9090633 49.47 µM 0.215839131325717 0.41289070269978 no 1366 0.414556572386329 1896 25236842 SGTC_2391 6285546 200 µM 0.213230302940567 0.413937159583111 no 1367 0.415573666699901 1866 846083 SGTC_1047 2043-3044 82 µM 0.212389109420661 0.414274711015062 no 1368 0.415901740700176 1898 669592 SGTC_2738 aclarubicin 5.55 µM 0.212226842585353 0.414339832223287 no 1369 0.415965033162227 1993 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31 SGTC_938 3126-1755 342 µM 0.211739338086168 0.41453549253378 no 1370 0.416155198246885 2058 1777771 SGTC_2236 dapsone 200 µM 0.210899830995329 0.414872479038757 no 1371 0.416482718003344 2053 2955 A bacterial DFR inhibitor. An anti-cancer agent. SGTC_2751 anetholtrithion 17.25 µM 0.210875960198492 0.414882061931474 no 1372 0.416492031647482 2013 2194 A chloretic substance that stimulates the liver to produce bile. SGTC_1835 st008666 49.2 µM 0.210427252754447 0.415062204226013 no 1373 0.416667112085164 1881 690455 SGTC_113 0099-0221 2.5 µM 0.210398631961115 0.415073695204166 no 1374 0.416678280147826 2019 89219 SGTC_1806 st050005 60.3 µM 0.209548352810083 0.415415107349975 no 1375 0.417010096517596 1880 5194765 SGTC_2455 5377712 9.75 µM 0.20951848361106 0.415427101876698 no 1376 0.417021753870792 1845 2243908 SGTC_2495 cafestol 54.53 µM 0.209196802316413 0.415556283914876 no 1377 0.417147304291756 1977 16667697 An anti-infammatory. SGTC_134 0269-0018 6.916 µM 0.209173082254878 0.415565809871874 no 1378 0.417156562434539 1896 4378915 SGTC_1530 rhein 70.4 µM 0.208606738655178 0.41579326771494 no 1379 0.417377624813026 2022 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death. SGTC_551 k048-0028 34.9 µM 0.20834583253243 0.41589806367753 no 1380 0.417479473774187 2011 6836383 SGTC_391 gliotoxin 8.33 µM 0.2077370176133 0.416142624481064 no 1381 0.417717156130947 1973 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion SGTC_1537 2',6'-dihydroxyflavanone 78 µM 0.20767560436004 0.416167295974414 no 1382 0.417741133637738 1936 5106787 A p450 inhibitor. SGTC_1847 st056231 15 µM 0.207602150813837 0.416196804838103 no 1383 0.417769812424056 1947 5393180 SGTC_1824 st053723 68.6 µM 0.20717645271767 0.416367831979118 no 1384 0.417936028183304 1895 675225 SGTC_1946 st076057 65.1 µM 0.207073276020161 0.41640928631302 no 1385 0.417976316202723 1931 953009 SGTC_2909 7941780 10.49 µM 0.205457785273381 0.41705847915623 no 1386 0.418607238482851 2072 1243215 SGTC_1154 4088-0362 150 µM 0.204956867566966 0.41725982141025 no 1387 0.418802912141038 2001 6618304 SGTC_2784 7567673 72.73 µM 0.204313933943869 0.41751827829508 no 1388 0.41905409096099 1985 3471247 SGTC_2571 chrysanthemic acid 100 µM 0.203254184854081 0.417944371154792 no 1389 0.419468181607115 1851 2743 An insecticide. SGTC_641 4092-0595 30 µM 0.20313292677637 0.417993131489367 no 1390 0.419515568174666 2003 786260 SGTC_1164 k060-0068 93.7 µM 0.200615434168264 0.41900575005626 no 1391 0.42049964435146 2038 5963676 SGTC_1649 st011737 51.3 µM 0.199688459054485 0.419378745599372 no 1392 0.420862120164996 1939 1761035 SGTC_2020 4017018 200 µM 0.19921059817667 0.419571055222374 no 1393 0.42104900471377 1957 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope. SGTC_3109 9122853 49.47 µM 0.198939823652619 0.419680033850307 no 1394 0.421154908653476 2007 1234709 SGTC_2382 9035899 200 µM 0.197298543488543 0.420340731453223 no 1395 0.421796959536554 1921 6462679 SGTC_1267 0828-0272 9.49 µM 0.196205767382134 0.420780753278533 no 1396 0.422224557038734 2054 745334 SGTC_871 0574-0004 149 µM 0.196134295605057 0.420809535859946 no 1397 0.422252526766429 1937 9551173 SGTC_2980 9014342 25.29 µM 0.1952456073882 0.421167457064125 no 1398 0.422600338249748 1961 2996599 SGTC_1884 5633444 25 µM 0.19485735024979 0.421323848980872 no 1399 0.422752311841767 1985 5724239 SGTC_775 4577-0580 57.3 µM 0.194062025251591 0.42164424859882 no 1400 0.423063657890425 2025 2006902 SGTC_2747 doxorubicin 7.63 µM 0.192854283328157 0.422130891044365 no 1401 0.423536544718471 2074 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_2371 9071574 200 µM 0.191927033713661 0.42250459383391 no 1402 0.423899680620579 2073 45596039 SGTC_916 4466-0038 42 nM 0.191005846962465 0.422875922235471 no 1403 0.424260506141366 2112 5722064 YGL116W CDC20 SGTC_2433 5607874 27.82 µM 0.190920458536522 0.422910345602419 no 1404 0.424293955699196 1953 2252428 SGTC_362 0310-0100 9.03 µM 0.189858238659326 0.423338616516076 no 1405 0.424710108952799 1960 790235 SGTC_697 0508-1955 564 µM 0.189335998519289 0.42354920905532 no 1406 0.424914741402705 2086 6243113 SGTC_1347 1493-0251 600 nM 0.187553357808972 0.42426822035515 no 1407 0.425613396173271 2076 3986378 SGTC_192 3455-0609 60.9 µM 0.186800901770688 0.424571792204279 no 1408 0.425908369926155 2002 3769639 SGTC_1446 4239-0190 62 µM 0.186665736271947 0.424626328296139 no 1409 0.425961361172894 1922 1340085 SGTC_1892 st058411 7.36 µM 0.18459065931131 0.425463753423713 no 1410 0.426775056415525 2077 3934738 SGTC_1435 4092-0789 56.7 µM 0.183264182267346 0.425999247494452 no 1411 0.427295368407181 2078 2248285 SGTC_2026 5148700 152 µM 0.183109386965374 0.426061746719973 no 1412 0.42735609528383 1960 79838 SGTC_731 3966-0296 387 µM 0.181921292684517 0.426541506280776 no 1413 0.427822247088918 1989 660956 SGTC_473 2-arachidonoylglycerol 10 µM 0.1773718974655 0.428379578326708 no 1414 0.429608139941898 1931 5282280 An endocannabinoid. SGTC_1949 st076024 69.1 µM 0.175310379232187 0.429212998747937 no 1415 0.430417878310268 2009 2921930 SGTC_598 3937-0236 20.2 µM 0.174197574784044 0.429663009261952 no 1416 0.43085509572083 2048 1379313 SGTC_193 1273-0060 1.558 µM 0.173808978081848 0.429820176675463 no 1417 0.431007794152441 2099 2847393 YHR072W ERG7 SGTC_422 cantharidin 155 µM 0.173487634356264 0.429950152115672 no 1418 0.431134073429902 1893 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_1313 1220-0047 237 µM 0.171851342192617 0.430612108528231 no 1419 0.43177720033435 2032 3528706 SGTC_2614 arthonioic acid 13.39 µM 0.171638781406028 0.430698113620992 no 1420 0.431860758357941 2071 6710684 SGTC_2898 9056270 58.44 µM 0.171020317693377 0.430948371444838 no 1421 0.432103894870149 2019 19154699 SGTC_3318 9139014 38.6185 µM 0.170213413275313 0.431274922402718 no 1422 0.432421151690039 1974 16643984 SGTC_348 k064-0012 10.7 µM 0.169594402570133 0.43152546539137 no 1423 0.432664562440919 2023 5066323 SGTC_2366 9070441 60.58 µM 0.169298632437267 0.431645187323905 no 1424 0.432780875806541 2006 6837235 SGTC_1493 4348-0038 111 µM 0.168884686661736 0.431812754973473 no 1425 0.432943672224963 2082 800424 SGTC_325 2810-4341 181 µM 0.16876866171603 0.431859724746861 no 1426 0.43298930450951 2116 774970 SGTC_2401 5128683 200 µM 0.168720861119328 0.431879075893233 no 1427 0.433008104609571 1965 708373 SGTC_2930 9013230 14.89 µM 0.167216522712549 0.432488161461343 no 1428 0.433599842105874 2069 2995857 SGTC_140 0062-0056 502.533 µM 0.166078450002393 0.432949057873493 no 1429 0.434047606517659 2046 3758964 SGTC_3258 9138477 49.47 µM 0.16602413638322 0.432971056075583 no 1430 0.434068977840297 2096 4970355 SGTC_2229 7354935 190 µM 0.16548276634619 0.433190334107844 no 1431 0.434282006643687 2106 318112 SGTC_3291 9121177 71.43 µM 0.161991566708604 0.434604910533903 no 1432 0.435656247474442 1986 17015612 SGTC_2125 5246583 200 µM 0.160461715066756 0.435225046164788 no 1433 0.436258688875222 2139 835267 SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM 0.158969876594323 0.435829926380361 no 1434 0.436846303493052 2026 6708514 SGTC_1948 st076329 66.6 µM 0.158067469466889 0.436195888973508 no 1435 0.437201816959165 2130 24208413 SGTC_168 3970-0862 530.542 µM 0.155788449470408 0.437120366275354 no 1436 0.438099887723113 2047 3135186 SGTC_3249 9135183 49.47 µM 0.153267899607031 0.438143219209316 no 1437 0.439093506974612 2066 4902779 SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM 0.152617476762569 0.438407231734963 no 1438 0.439349970998743 2063 676296 Flavone; oxidizing agent. SGTC_1081 sertraline 6 µM 0.152147742661516 0.438597918116961 no 1439 0.439535204652252 2140 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1 SGTC_1508 1080-0625 72.9 µM 0.151282807028782 0.438949071985759 no 1440 0.439876315593464 2144 767111 SGTC_1247 0448-0043 5.84 µM 0.151074226511697 0.439033760466819 no 1441 0.439958581694916 2019 3089013 YGL099W LSG1 SGTC_1620 st003704 16.5 µM 0.151030852440792 0.439051371686567 no 1442 0.439975689158751 2129 2834414 SGTC_421 streptovitacin 30 mM 0.150762972141891 0.43916014207912 no 1443 0.44008134814103 1995 91467 include heat shock SGTC_2128 5255449 168.493 µM 0.149891423331679 0.439514058401614 no 1444 0.440425139229932 2075 736008 SGTC_3068 9116768 49.47 µM 0.149391969798881 0.439716897031925 no 1445 0.440622173900166 2047 41904888 SGTC_280 3448-3607 3.04 µM 0.149381499219013 0.439721149525142 no 1446 0.440626304706705 2141 626179 SGTC_3342 9147791 14.508 µM 0.148363568270988 0.440134602400344 no 1447 0.441027925070085 2115 1838168 SGTC_2620 irigenin 100 µM 0.146369833110795 0.44094458629822 no 1448 0.441814720246511 2097 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro. SGTC_321 4534-3890 65.3 µM 0.144997744548815 0.441502160984811 no 1449 0.442356326280514 2138 699746 SGTC_2798 7813637 45.45 µM 0.143678377736199 0.442038420539475 no 1450 0.442877223043734 2083 956368 SGTC_1381 2324-0066 62.1 µM 0.14346209426236 0.44212633959675 no 1451 0.4429626229655 2058 10885928 SGTC_1819 st053448 58.6 µM 0.143168652854306 0.4422456278489 no 1452 0.443078493073215 2070 2857616 SGTC_2824 7998404 51.95 µM 0.142873324265676 0.442365688555406 no 1453 0.443195113279875 2067 837851 SGTC_888 0916-0002 6.97 µM 0.142455927633039 0.442535382929842 no 1454 0.443359944458303 2130 2802138 YIL048W NEO1 SGTC_474 dl-dihydrosphingosine 5 µM 0.142356070070157 0.442575982010416 no 1455 0.443399379962472 2127 3058739 A sphingolipid protein kinase C inhibitor. SGTC_588 3970-1144 52.9 µM 0.140483467655442 0.443337437038499 no 1456 0.444139006926253 2159 1888707 SGTC_527 4476-4215 268 µM 0.14032128047696 0.443403396987417 no 1457 0.444203075638953 2029 4418754 SGTC_341 1486-1430 230 µM 0.139814638190196 0.443609453573197 no 1458 0.444403223649481 2098 2054753 YPL210C SRP72 SGTC_853 0419-0306 21 µM 0.139397526718673 0.443779108509915 no 1459 0.444568013336118 2000 762713 SGTC_1136 pergolide 1.05886 µM 0.139281520802878 0.443826294315407 no 1460 0.444613845902868 2007 47811 A dopamine receptor agonist. SGTC_1867 st057372 64 µM 0.138987845599545 0.443945751273502 no 1461 0.444729876814979 2151 688837 SGTC_1944 st076371 56.9 µM 0.138820537787242 0.444013808607189 no 1462 0.444795982158377 1978 24208455 SGTC_605 1315-0399 119 µM 0.137503877908267 0.444549455889716 no 1463 0.445316263866934 2106 24020461 SGTC_2333 9017922 200 µM 0.137019178395591 0.444746668269066 no 1464 0.445507817958471 2149 3163164 SGTC_3014 9081533 49.47 µM 0.136456827032881 0.444975492424709 no 1465 0.445730076136059 2171 21367265 SGTC_2156 5649887 115 µM 0.136063301101476 0.445135631405774 no 1466 0.445885619571933 2151 54680440 YKL052C | YBR257W ASK1 | POP4 SGTC_2264 7948757 110.76 µM 0.135757770648197 0.445259968232996 no 1467 0.446006388022809 2071 2971411 SGTC_1889 st059080 5.18 µM 0.135381720711805 0.445413010634535 no 1468 0.446155037915442 2215 176925 Isolated from Daphnopsis sellowiana. SGTC_2345 9052315 157.45 µM 0.134847884216061 0.445630281968417 no 1469 0.446366072716657 2039 6469265 SGTC_3207 9114163 49.47 µM 0.134487861383142 0.445776820404633 no 1470 0.446508404551679 2184 849233 SGTC_2531 methyl deoxycholate 70.07 µM 0.134418149146043 0.445805195912205 no 1471 0.446535965463534 2063 16667744 Haematoxylin. SGTC_62 0180-0423 3.232 µM 0.133748302986005 0.446077862669446 no 1472 0.44680080400606 2122 30102 YGL099W LSG1 SGTC_2555 cholic acid 100 µM 0.133455063215431 0.44619723652435 no 1473 0.44691675033035 2076 6708657 Influences liver metabolism. SGTC_2122 5258151 111.688 µM 0.132706249368876 0.446502090385715 no 1474 0.447212850151165 2077 2173356 SGTC_273 hydroxyurea 18.1 mM 0.1322395907823 0.446692090420388 no 1475 0.447397393581936 2138 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12 SGTC_12 0849-0099 9.267 µM 0.13189985188753 0.446830422805298 no 1476 0.447531752891019 2178 6071388 SGTC_2206 7254556 146.969 µM 0.13170971043899 0.44690784602687 no 1477 0.447606952307873 2160 4398905 SGTC_2426 5582046 32.21 µM 0.131541533037053 0.446976327449707 no 1478 0.447673466690186 2129 2251934 SGTC_2045 5106652 78.05 µM 0.130480598495857 0.447408373740249 no 1479 0.448093101533466 2147 673349 SGTC_1744 st037937 38.9 µM 0.130454036514124 0.447419191427054 no 1480 0.448103608426714 2121 1016152 SGTC_2578 7,8-dihydroxyflavone 64.44 µM 0.129660065396085 0.447742563745687 no 1481 0.448417689487525 2094 1880 Intensifies effect of antibiotics on Staphylococcus aureus. SGTC_2213 7173844 200 µM 0.128873748383662 0.448062852899562 no 1482 0.448728774587984 2152 892728 SGTC_467 ro 31-8220 72.8 µM 0.128164216283194 0.448351894457392 no 1483 0.449009508874145 2183 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7 SGTC_2407 paclitaxel 400 µM 0.128117921475073 0.448370754493099 no 1484 0.449027826819853 2080 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_2752 diclazuril 33.15 µM 0.127817181385166 0.448493275797583 no 1485 0.449146826406438 2176 456389 An antifungal agent for coccidioides. YHR062C RPP1 SGTC_2831 7999036 19.48 µM 0.127429276832712 0.448651315097237 no 1486 0.449300322777714 2180 2988270 SGTC_2263 7948595 193.29 µM 0.125171645156653 0.449571275826799 no 1487 0.450193832277318 2114 2971371 SGTC_2247 cerulenin 830 nM 0.123912548898936 0.45008446215111 no 1488 0.450692258470989 2157 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12 SGTC_931 2812-0076 566 µM 0.123709686497995 0.450167153263212 no 1489 0.450772570932031 2118 3450959 SGTC_2283 7944793 200 µM 0.122555554732476 0.450637643451938 no 1490 0.451229525610034 2108 2970533 SGTC_151 3013-0144 2.285 µM 0.121189332453653 0.451194683493526 no 1491 0.45177053665433 2192 906558 YHR107C CDC12 SGTC_875 0709-0210 25.7 µM 0.120192675888506 0.451601103851295 no 1492 0.452165259755399 2234 6251364 SGTC_1501 4491-0275 38.4 µM 0.120105347383576 0.451636717420636 no 1493 0.452199848229237 2223 5104718 SGTC_1651 st011928 86.1 µM 0.118776167852525 0.452178820011419 no 1494 0.452726345150421 2153 720198 SGTC_454 lyso-paf C-16 6.67 µM 0.118265735761616 0.452387022230678 no 1495 0.452928552863607 2061 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_683 panaxydol 45 µM 0.118251865526783 0.452392680000099 no 1496 0.452934047728828 2159 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis. SGTC_1336 1486-0901 104 µM 0.116027480020943 0.453300147290147 no 1497 0.453815381484316 2115 5006114 SGTC_2926 9010726 65.15 µM 0.11548485765736 0.453521554401512 no 1498 0.454030411005031 2069 2994293 SGTC_3345 9148410 3.559 µM 0.11515820951395 0.453654844160899 no 1499 0.454159861109329 2183 4903596 SGTC_2060 5238662 140 µM 0.115152055765811 0.453657355266522 no 1500 0.454162299876037 2106 790130 SGTC_1666 st014829 29 µM 0.114962849829219 0.453734563764817 no 1501 0.454237284148426 2177 3858230 SGTC_465 cgp-37157 41 µM 0.114577219537904 0.453891931762697 no 1502 0.454390118474138 2201 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange. SGTC_2832 7992762 51.95 µM 0.113579889305952 0.454298955765668 no 1503 0.454785415089612 1945 2985177 SGTC_3020 9089140 49.47 µM 0.113458591340075 0.454348462393944 no 1504 0.454833495181611 2119 17217859 SGTC_2626 ethyl orsellinate 100 µM 0.112574393968175 0.45470936064584 no 1505 0.455183993314661 2138 75653 A natural product. SGTC_2293 7624732 200 µM 0.112352901015396 0.454799772142468 no 1506 0.455271799171223 2183 894453 SGTC_2566 crystal violet carbinol 226 nM 0.111475519848394 0.455157934466719 no 1507 0.455619638461592 1954 68050 Cationic dye that binds acidic phospholipids including cardiolipin. SGTC_1289 0976-0073 69.1 µM 0.111343403904787 0.455211869668535 no 1508 0.455672019011093 2144 3391136 SGTC_2896 9052656 71.43 µM 0.111186309474719 0.455276003197781 no 1509 0.455734303886225 2189 6469436 SGTC_1094 duloxetine 25.4 µM 0.11077718237087 0.455443034096559 no 1510 0.455896519899299 2161 60834 A selective serotonin reuptake inhibitor. SGTC_1261 0712-0010 12.7 µM 0.11077114198652 0.455445500212802 no 1511 0.455898914924261 2184 2840123 SGTC_1498 4478-3555 97.6 µM 0.110173542709876 0.455689491384615 no 1512 0.456135872188751 2227 3437919 SGTC_1403 3909-7815 62.9 µM 0.109441105985908 0.455988557528172 no 1513 0.456426315836543 2132 6615483 SGTC_2880 9042983 58.44 µM 0.108174844068773 0.456505652138763 no 1514 0.456928499682645 2132 6464714 SGTC_2202 7226349 200 µM 0.106339510798769 0.457255265011146 no 1515 0.457656492105176 2204 844334 SGTC_3038 9091290 49.47 µM 0.105945798861292 0.457416090336102 no 1516 0.457812678143107 2197 25236843 SGTC_648 0375-0473 33.3 µM 0.105871251272304 0.457446542675872 no 1517 0.457842252002973 2135 1713139 SGTC_2331 7980721 200 µM 0.105843009326039 0.457458079443464 no 1518 0.457853455958968 2168 2981221 SGTC_1096 rimcazole 32.2 µM 0.105016440188695 0.457795746799697 no 1519 0.458181381734847 2093 18528119 A dopamine reuptake inhibitor. SGTC_2082 5219693 150 µM 0.1033925255293 0.458459231670719 no 1520 0.458825722059333 2199 2834649 SGTC_237 nikkomycin 200 µM 0.102099051412777 0.458987790939858 no 1521 0.459339026972015 2214 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine. SGTC_2486 5283202 22.39 µM 0.101693386754476 0.459153574846658 no 1522 0.45950002576916 2095 1377751 SGTC_1612 st002233 45.4 µM 0.101580571371974 0.459199680631594 no 1523 0.459544800732447 2229 1035021 SGTC_798 1287-0182 476 µM 0.101015184957725 0.459430752982378 no 1524 0.459769202991338 2223 1649755 SGTC_423 5-fluorouracil 457 µM 0.099954200539571 0.459864412224619 no 1525 0.460190342977087 2128 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_603 3794-0023 45.9 µM 0.099003339616192 0.46025310096107 no 1526 0.460567809251727 2230 3802260 SGTC_349 k015-0014 24 µM 0.0977681401899358 0.460758077003818 no 1527 0.461058203296877 2155 2196908 SGTC_1344 1488-0097 29.1 µM 0.0968807026083191 0.461120919655795 no 1528 0.461410566898316 2173 747966 SGTC_2150 5556613 200 µM 0.0962262468772151 0.461388524810514 no 1529 0.461670442771893 2157 743190 SGTC_2710 st078562 53.7235 µM 0.0948082417804427 0.461968403027574 no 1530 0.462233570184809 2231 17250908 SGTC_1626 st003712 1.76 µM 0.0947746690518277 0.461982133225211 no 1531 0.462246903727216 2169 24207035 SGTC_2856 9022925 19.48 µM 0.0938907143624769 0.462343659341416 no 1532 0.462597985058996 2162 4944862 SGTC_1489 4065-0444 182 µM 0.0938151454804759 0.462374567491444 no 1533 0.462628000197316 2251 2877968 SGTC_1374 2889-5571 141 µM 0.0934259307038793 0.462533762387734 no 1534 0.462782595441582 2147 2853281 SGTC_3245 9134821 49.47 µM 0.0932493136966356 0.462606003471334 no 1535 0.462852749180002 2224 17014901 SGTC_3264 9137442 49.47 µM 0.0931426193955747 0.462649644894194 no 1536 0.46289512960022 2244 17015726 SGTC_1655 st012546 55.1 µM 0.092240183742391 0.463018788219964 no 1537 0.463253606052708 2195 720985 YLR208W SEC13 SGTC_25 0118-0223 35.662 µM 0.0896413551526719 0.464082021689789 no 1538 0.464286110008398 2233 5333628 SGTC_733 4069-0007 56.1 µM 0.0895818578779806 0.464106366264229 no 1539 0.464309750875106 2240 5717425 YNL287W SEC21 SGTC_2123 5259487 200 µM 0.0886505571286678 0.464487445215879 no 1540 0.464679813721317 2237 2173474 SGTC_2984 9022109 38.96 µM 0.0877013657865904 0.464875878339959 no 1541 0.465057017033877 2266 6459207 SGTC_2046 4110841 106 µM 0.0866888840003803 0.465290248403015 no 1542 0.465459406217756 2280 44119630 YMR134W ERG29 SGTC_2145 5634607 200 µM 0.086433409926683 0.465394810132843 no 1543 0.46556094450887 2189 308662 SGTC_2756 carbadox 75.1 µM 0.0863470177884583 0.465430169688056 no 1544 0.465595281612599 2172 2553 A substituted quinoxaline antibiotic. YLR208W SEC13 SGTC_224 benfluorex 43.875 µM 0.0852591605263963 0.465875443525284 no 1545 0.466027679222679 2252 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis. SGTC_711 k292-0785 179 µM 0.0833318849097533 0.466664406531383 no 1546 0.466793823981918 2242 4146315 SGTC_2819 7996655 46.38 µM 0.0824547874819291 0.467023504823128 no 1547 0.467142535108083 2245 6456960 SGTC_2015 5119600 184 µM 0.0816558025165588 0.467350645942901 no 1548 0.467460212708533 2228 2828786 SGTC_1239 0337-0584 35.4 µM 0.0800257620510895 0.468018127489303 no 1549 0.468108383260825 2254 914301 YML130C ERO1 SGTC_503 tyrphostin 8 294 µM 0.0765750092083465 0.469431462782247 no 1550 0.469480820163801 2269 92970 A tyrosine kinase inhibitor. YOR207C RET1 SGTC_87 0100-0052 35.5 µM 0.0762971502984586 0.469545283294371 no 1551 0.469591346484937 2258 200187 YGR083C | YDR527W GCD2 | RBA50 SGTC_2860 9025725 38.96 µM 0.0757590560478867 0.469765712170261 no 1552 0.469805395504104 2119 40546248 SGTC_2786 7743617 45.45 µM 0.0741606332271233 0.470420556203982 no 1553 0.470441284845592 2181 583674 SGTC_1930 st074634 34.3 µM 0.0739252255574715 0.470517005139064 no 1554 0.470534941835286 2279 684253 YOR116C RPO31 SGTC_338 4055-0136 114 µM 0.0737651392959426 0.470582595109579 no 1555 0.470598633118676 2265 2900563 SGTC_2341 7987486 176.74 µM 0.0729675440360781 0.47090939484515 no 1556 0.470915972373472 2265 1258686 SGTC_836 0330-0104 1.35 µM 0.0728251245916548 0.470967750615756 no 1557 0.470972638752123 2283 46494820 SGTC_2540 epiandrosterone 100 µM 0.0726603500411459 0.471035267075192 no 1558 0.47103820059687 2300 441302 A steroid. SGTC_2836 9010338 19.48 µM 0.0722435144147203 0.471206069406701 no 1559 0.471204058062911 2193 2994051 SGTC_277 nystatin 15.5 µM 0.0721935803757857 0.471226530706235 no 1560 0.471223926981298 2281 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_2591 skatole 100 µM 0.0707754546523429 0.471807662714335 no 1561 0.471788233587035 2215 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite. SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM 0.0706561571679547 0.471856552239199 no 1562 0.471835707546838 2278 1377 SGTC_614 0462-0418 107 µM 0.070276517102033 0.472012136062062 no 1563 0.471986786462019 2248 5188303 SGTC_816 0325-0417 81.3 µM 0.0701789500619249 0.472052121608114 no 1564 0.472025614213359 2190 68101 SGTC_1445 4239-0156 97.7 µM 0.0697828405745214 0.472214460611177 no 1565 0.472183252558383 2274 4008346 SGTC_841 0251-0215 91.2 µM 0.069529110853826 0.472318450019667 no 1566 0.472284230803158 2216 3888614 SGTC_132 0417-1715 25.805 µM 0.0682533890418946 0.472841324418732 no 1567 0.472791963855301 2304 6769098 SGTC_2395 5646831 180.19 µM 0.0678987272468587 0.47298669641677 no 1568 0.472933125963296 2251 6808628 SGTC_1647 st011722 22.4 µM 0.06774879587226 0.473048152733593 no 1569 0.472992802511826 2260 2854783 SGTC_674 0498-0004 451 µM 0.0674349834391543 0.473176785366089 no 1570 0.473117709902932 2197 4231473 SGTC_2811 7967822 32.47 µM 0.0669079741784266 0.47339281428694 no 1571 0.473327482395016 2253 2232244 SGTC_3265 9137266 49.47 µM 0.0664272251402181 0.473589887282555 no 1572 0.473518847769606 2307 17224265 SGTC_2253 7938677 135.83 µM 0.0650292154787507 0.474163008607056 no 1573 0.474075369445266 2297 2301972 SGTC_883 0850-0245 24.6 µM 0.0636863086637344 0.47471359060534 no 1574 0.474610003359182 2239 6823229 YPR165W RHO1 SGTC_1658 st012944 20 µM 0.063359563340725 0.474847561149457 no 1575 0.474740093151141 2268 24207260 SGTC_1902 st060212 70.5 µM 0.06207505857401 0.475374255033178 no 1576 0.475251529529548 2311 688944 SGTC_1349 flufenamic acid 69 µM 0.0619487267907283 0.475426058019173 no 1577 0.475301831808109 2273 3371 A non-steroidal anti-inflammatory. SGTC_998 3996-0085 177 µM 0.0617554823634201 0.475505299676313 no 1578 0.47537877785405 2255 715391 SGTC_2324 6149169 200 µM 0.0615928780492192 0.475571977823619 no 1579 0.47544352433448 2271 2888231 SGTC_3269 9137823 49.47 µM 0.0611739746203069 0.475743758113543 no 1580 0.475610328074262 2222 17682936 SGTC_3066 9117245 49.47 µM 0.0606619458540004 0.475953732555371 no 1581 0.475814219324499 2263 17176980 SGTC_610 4215-0184 155 µM 0.0599965256051849 0.47622662025063 no 1582 0.476079200936323 2246 5605015 SGTC_2612 dictamnine 15.46 µM 0.0596174014159132 0.476382103420548 no 1583 0.476230179347155 2230 68085 A quinoline derivative and established mutagen. YOR116C RPO31 SGTC_3214 9129694 49.47 µM 0.0589634783871258 0.476650293177022 no 1584 0.476490598750834 2274 17158655 SGTC_1085 doxorubicin 7.67 µM 0.0587108226959798 0.476753916267255 no 1585 0.476591219472406 2316 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_2313 7726885 200 µM 0.0586301889152801 0.47678698738147 no 1586 0.476623332379179 2256 726423 SGTC_1562 morin hydrate 59.1 µM 0.0563642470610611 0.477716404617644 no 1587 0.477525819184258 2256 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase. SGTC_227 fluconazole 33.516 µM 0.0559440529644472 0.477888768337069 no 1588 0.477693188284475 2251 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C SGTC_2286 7945697 125 µM 0.0556554489183193 0.478007156184067 no 1589 0.477808145534843 2246 1245733 SGTC_955 1216-0110 33 µM 0.0548604728020736 0.478333272187279 no 1590 0.478124811281671 2279 3619719 SGTC_3304 9125678 46.087 µM 0.0548348854557829 0.478343768899621 no 1591 0.47813500381348 2283 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2 SGTC_2835 9006588 71.43 µM 0.0537940681872108 0.478770756640787 no 1592 0.478549617789586 2181 2345538 SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM 0.0535369120997547 0.478876256834683 no 1593 0.478652060602118 2270 368090 SGTC_2853 9015042 58.44 µM 0.0526674869710741 0.479232955865513 no 1594 0.478998422347299 2299 6457456 SGTC_2875 9039966 71.43 µM 0.0515451935824198 0.47969342370419 no 1595 0.479445545210335 2270 6463691 SGTC_1605 st000082 49.1 µM 0.0506202524598712 0.480072939913979 no 1596 0.479814062191761 2288 1114022 SGTC_199 4063-0024 41.6 µM 0.0505098469571855 0.480118242041189 no 1597 0.479858051342523 2301 306215 SGTC_1570 verbenone 133 µM 0.0502764373575708 0.480214016657188 no 1598 0.479951050141478 2333 29025 A natural terpanoid with antifungal properties. SGTC_3127 9126946 49.47 µM 0.0499119859496435 0.4803635637468 no 1599 0.480096262901465 2189 27243249 SGTC_3206 9114350 49.47 µM 0.0491550954463924 0.480674151053773 no 1600 0.480397848309915 2326 17087243 SGTC_444 curcumin 90.4 µM 0.0490805763721 0.480704730326463 no 1601 0.480427541279666 2298 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. SGTC_2437 5741531 144.16 µM 0.0470172887428189 0.481551455125165 no 1602 0.481249724171156 2311 2262990 SGTC_1067 clotrimazole 1.36 µM 0.0470113809739097 0.481553879656135 no 1603 0.481252078426657 2264 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_1101 ebselen 5.29 µM 0.0463360093319754 0.481831054664942 no 1604 0.481521219411875 2332 3194 A potent scavenger of hydrogen peroxide and hydroperoxides. SGTC_117 lucigenin 22.078 µM 0.0450034627286074 0.482377962330538 no 1605 0.48205227444711 2215 65100 An acridine derivative; a dye stuff and potential carcinogen. SGTC_2528 xanthyletin 44.79 µM 0.0443179650467431 0.482659319272428 no 1606 0.482325475853329 2287 65188 An natural product with antifungal activity of unknown mechanism. SGTC_3303 9125618 40.5795 µM 0.0442153396594287 0.482701441773683 no 1607 0.482366377365712 2271 22695467 SGTC_1941 st076221 61.8 µM 0.0436888389046778 0.482917546578286 no 1608 0.482576217993498 2331 2828568 SGTC_1194 1488-0194 225 µM 0.0425558955654466 0.483382585638479 no 1609 0.483027776927824 2306 1391452 SGTC_825 1988-2224 89.6 µM 0.0423126333641491 0.48348244040274 no 1610 0.483124737169053 2312 1180859 SGTC_804 1595-0054 20.9 µM 0.0416979984157885 0.483734741610749 no 1611 0.483369724803951 2269 761523 Stimulates phospholipase C. SGTC_103 0844-0104 51.839 µM 0.0413454743305147 0.483879452000508 no 1612 0.48351024038521 2335 5375804 SGTC_1860 st056228 74.6 µM 0.0411740427723714 0.48394982506031 no 1613 0.483578573493067 2233 688679 SGTC_839 0122-0028 230 µM 0.0410863439858985 0.48398582581288 no 1614 0.483613530666012 2297 759448 SGTC_725 1497-0963 19 µM 0.0410720170296563 0.483991707106295 no 1615 0.483619241474081 2323 3549977 SGTC_146 3448-8650 53.125 µM 0.0387545782678902 0.484943073258463 no 1616 0.484543029448635 2234 2891488 YIL048W NEO1 SGTC_2195 6536160 144.242 µM 0.0386507563961537 0.484985696761037 no 1617 0.484584417373858 2338 3834386 SGTC_1478 0453-0656 35.7 µM 0.0374594825479283 0.485474779890742 no 1618 0.485059322849677 2334 5258496 SGTC_3352 9151559 45.5865 µM 0.0369278234209477 0.485693062163388 no 1619 0.485271277495364 2306 17159339 SGTC_768 0384-0033 77.3 µM 0.0367043753949586 0.485784804076028 no 1620 0.485360359967443 2281 3965305 YMR134W ERG29 SGTC_1947 st076332 61.6 µM 0.0360214854133233 0.486065185476446 no 1621 0.485632613593772 2342 24208416 SGTC_2573 2',4'-dihydroxychalcone 15.04 µM 0.0359799401267786 0.486082243390159 no 1622 0.485649177028115 2310 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_738 1315-0003 72.4 µM 0.0353450921663132 0.486342906234692 no 1623 0.485902283713291 2326 6251474 SGTC_2879 9041815 71.43 µM 0.0348865092135756 0.486531199893666 no 1624 0.486085119076927 2340 4942971 SGTC_1192 1488-0095 21.4 µM 0.0348123730216876 0.48656164041605 no 1625 0.486114677184004 2280 915875 SGTC_2384 9036245 200 µM 0.0347177620319466 0.486600488059918 no 1626 0.486152398705796 2302 6462766 SGTC_3210 9128157 49.47 µM 0.0342734930999718 0.486782908322093 no 1627 0.486329530944711 2188 17590849 SGTC_1317 1273-0028 910 nM 0.0339875007400506 0.486900340464274 no 1628 0.486443558954131 2337 5917803 YLR359W | YHR072W ADE13 | ERG7 SGTC_1038 k292-0204 154 µM 0.0339710676451155 0.486907088139066 no 1629 0.486450111026922 2342 4454212 SGTC_2536 dehydroabietamide 32.04 µM 0.0338350121543013 0.486962954704224 no 1630 0.486504358129439 2345 3983547 SGTC_244 nsc-207895 1.295 µM 0.0337003141067195 0.487018264133466 no 1631 0.486558064247599 2336 42640 SGTC_2032 5185112 25.99 µM 0.0336701613791727 0.48703064541733 no 1632 0.486570086622686 2339 5718189 SGTC_2192 5915882 198.485 µM 0.0321304160652334 0.48766291050429 no 1633 0.487184023707269 2340 2876149 SGTC_1266 0828-0227 32.9 µM 0.0312976758445781 0.488004871355402 no 1634 0.487516071954434 2320 3913820 SGTC_3297 9117502 71.43 µM 0.0308885130970394 0.488172895358032 no 1635 0.48767922538701 2371 7453720 SGTC_3270 9137563 49.47 µM 0.0301839862478652 0.488462216484588 no 1636 0.487960159918014 2331 17015724 SGTC_710 3448-4187 58 µM 0.0299513216015529 0.488557763932526 no 1637 0.48805293773436 2343 3946412 SGTC_3151 9099821 49.47 µM 0.0297774165187473 0.488629181257686 no 1638 0.488122284892993 2327 17174189 SGTC_662 k832-1615 104 µM 0.0281563348029983 0.489294925555114 no 1639 0.488768731591527 2326 5878478 SGTC_1646 st011709 75.6 µM 0.0264474207321174 0.489996773019465 no 1640 0.489450235543763 2361 5757843 SGTC_1583 clindamycin 39.6 µM 0.0257874575036276 0.490267826958352 no 1641 0.489713432992829 2320 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis. SGTC_2778 tioconazole 65.09 nM 0.0255893911636058 0.490349175799852 no 1642 0.48979242396288 2344 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_3153 9100258 49.47 µM 0.0227383363405778 0.491520189941282 no 1643 0.490929497877707 2346 25236848 SGTC_2385 9074692 200 µM 0.0219744057633653 0.491833972086694 no 1644 0.491234185924668 2353 17046906 SGTC_145 3737-0113 38.366 µM 0.0206764843915508 0.492367100798454 no 1645 0.491751863873415 2365 6849351 SGTC_3227 9130768 49.47 µM 0.0199379898988238 0.492670447830566 no 1646 0.492046419802395 2366 17720899 SGTC_1350 1495-0454 146 µM 0.0194899909720186 0.492854471787316 no 1647 0.492225110787645 2369 1069057 SGTC_1953 st076800 12.1 µM 0.0187515263903644 0.493157813257387 no 1648 0.492519661675828 2322 297591 SGTC_2876 9059903 25.97 µM 0.0181020273718155 0.493424613333302 no 1649 0.492778730304247 2377 6916095 SGTC_2302 7771753 200 µM 0.0175040584260349 0.493670248579064 no 1650 0.493017247593709 2346 2203047 SGTC_2225 6654152 15.4 µM 0.0174533541008165 0.493691077145936 no 1651 0.493037472603177 2372 97582 YGR029W | YLR033W ERV1 | RSC58 SGTC_261 5-fluorouridine 15.376 µM 0.0170291864510289 0.493865319443946 no 1652 0.493206665862206 2371 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_849 0386-0493 241 µM 0.0167223671114648 0.493991357384548 no 1653 0.493329051640247 2358 726119 SGTC_3338 9144300 39.5675 µM 0.0165356526821247 0.494068057870608 no 1654 0.493403529622178 2355 4901274 SGTC_639 0833-0042 114 µM 0.0160473784222178 0.494268637254856 no 1655 0.493598297018291 2356 5978911 YPR085C | YHR062C ASA1 | RPP1 SGTC_1206 3978-0017 132 µM 0.0156628889459886 0.49442658365482 no 1656 0.493751666847114 2328 3873677 SGTC_743 1275-0778 158 µM 0.014497782020423 0.49490520912548 no 1657 0.494216424384852 2375 2849257 YMR203W TOM40 SGTC_1821 st053465 65.6 µM 0.0144267229084132 0.494934400425253 no 1658 0.494244769904551 2360 675086 SGTC_1692 fluoroquinolonic acid 71 µM 0.0108168033733287 0.496417398648583 no 1659 0.495684803944404 2357 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2 SGTC_939 1165-0479 45.3 µM 0.010561512232978 0.496522277424483 no 1660 0.495786644555602 2389 1377347 SGTC_56 0957-0365 83.25 µM 0.0103550088150703 0.496607113391134 no 1661 0.495869022994704 2378 6752360 SGTC_3102 9121669 49.47 µM 0.0102159557850186 0.496664239400183 no 1662 0.495924494193306 2362 41905072 SGTC_1223 0764-0573 147 µM 0.00978243513580585 0.496842339545388 no 1663 0.496097435262472 2384 1609797 SGTC_126 0417-1624 672.48 µM 0.00947997797026948 0.49696659620466 no 1664 0.496218092617128 2386 41912 YDL195W SEC31 SGTC_1700 st030840 7.9285 µM 0.00810057214087903 0.497533292760212 no 1665 0.496768374620416 2393 5499307 SGTC_2362 9071156 126 µM 0.00783840868068557 0.497640997071259 no 1666 0.496872959387477 2387 653133 SGTC_2089 5281248 129.67 µM 0.00610009817344983 0.498355149142929 no 1667 0.497566428016709 2393 2737878 SGTC_903 1134-0042 114 µM 0.00605072477958096 0.49837543335798 no 1668 0.497586124787535 2387 701009 SGTC_724 3910-0327 137 µM 0.00560660427467737 0.498557892859661 no 1669 0.497763300223432 2385 2885483 SGTC_3307 9126885 69.2785 µM 0.00478183882252746 0.49889673476025 no 1670 0.498092329585758 2393 24824909 SGTC_664 1222-0054 14.9 µM 0.00427125121903187 0.499106502052684 no 1671 0.498296022479624 2393 6813991 SGTC_2621 lithochol-11-enic acid 100 µM 0.00401812667241561 0.499210494588026 no 1672 0.498397003695853 2398 6708711 SGTC_412 gemfibrozil 100 µM 0.00401228854430213 0.499212893098638 no 1673 0.498399332753222 2392 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels. SGTC_2962 9082311 13.18 µM 0.00352479238290813 0.499413173947338 no 1674 0.498593814200602 2389 16459453 SGTC_1049 3226-0134 66 µM 0.00250861200888388 0.499830657585265 no 1675 0.498999209654218 2398 5702385 SGTC_1340 1486-1359 257 µM 0.00242923372901121 0.499863269066304 no 1676 0.499030876909681 2396 4309068 SGTC_1931 st074438 57.1 µM 0.00226945676229161 0.499928911251186 no 1677 0.499094618521164 2401 2787313 SGTC_2920 7982904 15.77 µM 0.00210948206896404 0.499994634671272 no 1678 0.499158439037087 2400 6456808 SGTC_2844 9010103 25.97 µM 0.00208336301393198 0.499994634671272 no 1679 0.499168859009566 2396 2480525 SGTC_2918 7977171 22.06 µM 0.00150384442040791 0.499756547377725 no 1680 0.499400053103688 2403 2236483 SGTC_2461 5755302 26.15 µM 0.00118930459770519 0.49962732302145 no 1681 0.49952553622355 2402 2788904 SGTC_1444 4112-3581 28 µM 0.00117159163278803 0.499620045894683 no 1682 0.499532602669243 2401 2877249 SGTC_3085 9117376 49.47 µM 0.000490976703777398 0.499340424778739 no 1683 0.49980412864204 2403 16480349 SGTC_1936 st074407 74.3 µM 0.000397158132799256 0.499301880754494 no 1684 0.499841556832986 2405 809813 SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM 0.000260192746506902 0.499245610487234 no 1685 0.499896198113536 2404 6708760 SGTC_2603 homopterocarpin 100 µM 0 0.499138714066227 no 1686 0.5 2405 101795 A weak amylase inhibitor. SGTC_2307 7538926 6.34 µM -0.000284346907472265 0.499021894329047 no 1687 0.499886561997837 2408 96582 SGTC_2713 st079149 53.4 µM -0.000835076469701726 0.498795635450641 no 1688 0.499666852727588 2408 3103253 SGTC_2463 5473429 200 µM -0.00196161659880221 0.49833281482959 no 1689 0.499217428702682 2416 5399405 SGTC_3325 9138760 55.175 µM -0.00211468425136854 0.4982699296427 no 1690 0.499156363671205 2411 43844959 SGTC_2503 beta-caryophyllene alcohol 24.72 µM -0.00315410202903201 0.497842904116093 no 1691 0.498741697430261 2423 61125 An anti-inflammatory. SGTC_2497 7-hydroxyflavone 100 µM -0.00316546360253992 0.497838236436987 no 1692 0.498737164840844 2408 5281894 SGTC_3174 9107204 49.47 µM -0.00318483354278624 0.497830278678535 no 1693 0.498729437391663 2412 3938802 SGTC_297 0986-0032 24 µM -0.00372756835743008 0.49760730713188 no 1694 0.49851291882291 2413 2847425 SGTC_330 1488-0319 80.1 µM -0.00406224021879693 0.497469814380822 no 1695 0.498379405080697 2421 6846614 SGTC_1917 st066507 28.5 µM -0.00411678958098488 0.497447403974233 no 1696 0.498357643215729 2388 3156428 SGTC_2473 5854593 8.94 µM -0.00419709013003827 0.497414414273148 no 1697 0.498325608208367 2411 2872951 SGTC_211 3455-0679 143.504 µM -0.00507023804262849 0.497055701991874 no 1698 0.497977276339565 2408 748649 SGTC_859 0439-0102 54.6 µM -0.00539117344115932 0.496923853815515 no 1699 0.497849243391884 2415 610143 SGTC_3263 9137018 49.47 µM -0.00618487532519479 0.496597782981338 no 1700 0.497532607464509 2422 43844957 SGTC_3326 9140064 16.379 µM -0.00673369931211345 0.496372314887803 no 1701 0.497313662941869 2424 1868434 SGTC_1204 4049-0315 18.3 µM -0.00678278800193064 0.496352148307678 no 1702 0.497294079835236 2440 588402 SGTC_2380 9035439 200 µM -0.00749946563739812 0.496057724406822 no 1703 0.497008174121221 2462 6462575 SGTC_2870 9038528 12.99 µM -0.00756967376798702 0.496028881772769 no 1704 0.496980165924528 2466 6463316 SGTC_1940 st075990 51.1 µM -0.00988875926237925 0.495076176565698 no 1705 0.496055020124623 2524 1084979 SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM -0.0108440572421533 0.494683737761151 no 1706 0.495673931861483 2418 442882 SGTC_650 1328-0195 38 µM -0.0128469654044097 0.493860955219997 no 1707 0.494874943302801 2424 2780821 SGTC_2804 7954240 19.48 µM -0.0132651420871481 0.493689173950734 no 1708 0.494708129162814 2440 828705 SGTC_376 3970-0862 59.1 µM -0.0133929313478413 0.493636680099935 no 1709 0.49465715315226 2439 3135186 SGTC_69 0096-0274 206.684 µM -0.0137096988310681 0.493506557396743 no 1710 0.494530792813494 2569 6741392 SGTC_1745 st081495 74 µM -0.0145348894205909 0.493167586393974 no 1711 0.494201622233676 2441 13842402 YBL026W LSM2 SGTC_1958 st076513 41.9 µM -0.0146659730904481 0.493113740416964 no 1712 0.494149332989151 2435 732122 YGL099W LSG1 SGTC_3147 9097027 49.47 µM -0.0149908985537604 0.492980269498285 no 1713 0.494019720734944 2444 25236841 SGTC_2137 5261020 140 µM -0.015688153980765 0.492693857798599 no 1714 0.493741588794802 2430 763655 SGTC_2685 mycophenolic acid 18.85 µM -0.0167427204345365 0.492260680607636 no 1715 0.49332093297573 2445 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_2658 polymyxin b sulfate 77.05 µM -0.0168401588814099 0.492220656922973 no 1716 0.493282066139237 2442 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides.  YIL048W NEO1 SGTC_2199 6590217 200 µM -0.0173849414858882 0.491996884211531 no 1717 0.493064761147429 2444 703109 SGTC_2711 st079103 59.1 µM -0.0175235112303083 0.491939966259656 no 1718 0.493009488237727 2454 54693780 SGTC_1118 chelidonine 707.474 nM -0.0177197292810128 0.491859369368348 no 1719 0.492931220714067 2438 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor. SGTC_3099 9120367 49.47 µM -0.0178770387315081 0.491794754489286 no 1720 0.492868473262656 2444 24824940 SGTC_3309 9129340 25.759 µM -0.0182851093260298 0.491627140442688 no 1721 0.492705703259227 2464 17158987 SGTC_1708 st033234 31.827 µM -0.0184358309661282 0.49156523225224 no 1722 0.492645584158612 2479 674664 SGTC_1279 0874-0590 65.2 µM -0.0188000052599663 0.491415650249943 no 1723 0.492500324813746 2463 3523074 SGTC_1909 st060837 51.5 µM -0.0189382234356264 0.491358878431775 no 1724 0.492445193555035 2453 678937 SGTC_2697 mebhydrolin 72.4 µM -0.0202631426854224 0.490814689335203 no 1725 0.491916728811153 2445 22530 H1 Histamine receptor antagonist. YIL048W NEO1 SGTC_765 1319-0117 244 µM -0.0203992213492782 0.490758798181719 no 1726 0.491862452497628 2441 3487746 YGL099W LSG1 SGTC_2807 7945238 51.95 µM -0.0208177018804488 0.49058691815611 no 1727 0.491695538370141 2466 17148797 SGTC_1565 sinapyl alcohol 95.1 µM -0.0209289044138497 0.490541244891995 no 1728 0.491651184641299 2454 5280507 A phenol propionate derived from cinnamic acid. SGTC_2704 st078022 71.1 µM -0.021765788218155 0.490197522795391 no 1729 0.491317392382483 2446 54697681 SGTC_887 0885-0007 9.62 µM -0.0220684827118439 0.490073202911972 no 1730 0.491196663751502 2526 5719458 SGTC_1814 st052110 31.539 µM -0.0223914224748762 0.489940569142317 no 1731 0.491067861255713 2445 674163 SGTC_2219 9098279 200 µM -0.0224743088346905 0.48990652727485 no 1732 0.491034802701456 2445 902349 SGTC_2329 6138490 200 µM -0.0234454480052015 0.489507680811495 no 1733 0.490647476345566 2565 720019 SGTC_3223 9129970 49.47 µM -0.0236353166986239 0.489429703029801 no 1734 0.49057175068073 2462 17248386 SGTC_397 arbidol 50 µM -0.0243508460286171 0.489135843652997 no 1735 0.490286377936009 2502 131410 A RNA synthesis inhibitor. SGTC_594 1487-1584 10.8 µM -0.0248483048447631 0.48893154670564 no 1736 0.490087980621604 2446 5013332 SGTC_3141 9094609 49.47 µM -0.0280381604594904 0.487621604518056 no 1737 0.488815857727922 2465 25236309 YDL196W YDL196W SGTC_1181 1222-0449 220 µM -0.0286250665816247 0.487380600497195 no 1738 0.488581810016133 2471 658318 SGTC_2043 5101342 149 µM -0.0287108538471303 0.487345373652879 no 1739 0.488547599909523 2470 678451 SGTC_1270 0831-1170 17.3 µM -0.0291479445401941 0.487165892541221 no 1740 0.488373298905478 2454 6764716 SGTC_2992 9074591 71.4286 µM -0.0291598533772098 0.487161002490913 no 1741 0.488368549985483 2455 17741321 SGTC_823 0417-1665 178 µM -0.0303737327585837 0.486662565145912 no 1742 0.487884496704764 2492 3429856 SGTC_1379 2144-0755 36.5 µM -0.0314989697152113 0.48620054432017 no 1743 0.487435806893384 2467 5392327 SGTC_1788 fluconazole 20 µM -0.0316566438963543 0.486135804972563 no 1744 0.487372935350307 2525 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11 SGTC_1394 3474-0001 65.7 µM -0.0322679661095186 0.485884806021262 no 1745 0.487129177618227 2499 5017666 YIL048W NEO1 SGTC_784 4579-0127 173 µM -0.0326762855890445 0.485717159797222 no 1746 0.486966367574321 2555 1948547 SGTC_3311 9131146 2.8755 µM -0.0336682065427803 0.485309911322827 no 1747 0.486570866047665 2511 4900406 YPR165W RHO1 SGTC_2485 5633444 17.78 µM -0.0338371813976074 0.485240537600858 no 1748 0.486503493221818 2499 5724239 SGTC_2148 5546263 113.568 µM -0.033838698962696 0.485239914556695 no 1749 0.486502888147447 2475 792097 SGTC_1464 k208-0027 110 µM -0.0346485467918134 0.484907432538237 no 1750 0.486179994988459 2455 X1464 SGTC_1766 st045414 44.774 µM -0.0373345508634236 0.483804773296483 no 1751 0.485109128541028 2481 253960 SGTC_532 1548-0774 215 µM -0.0382348295315984 0.483435217906291 no 1752 0.484750225619493 2585 5932993 SGTC_2991 9074669 71.4286 µM -0.038289009789953 0.483412977902852 no 1753 0.48472862663964 2508 17333109 SGTC_1202 1988-0068 29.6 µM -0.0385536627295074 0.48330434346279 no 1754 0.484623123293444 2482 2850480 SGTC_1188 1403-0014 4.57 µM -0.0388074488627828 0.483200170781141 no 1755 0.484521952988056 2476 9614867 SGTC_2598 perillyl alcohol 100 µM -0.0389917965229235 0.483124501525795 no 1756 0.484448464533929 2512 10819 An apoptosis inducer. SGTC_1846 st056244 14.8 µM -0.039420711048196 0.482948447171752 no 1757 0.484277483856733 2527 5393182 SGTC_3202 9113761 49.47 µM -0.0395376996190414 0.482900428046373 no 1758 0.484230848526781 2542 4798415 SGTC_1597 7-benzyloxygramine 47.5 µM -0.0399857819654941 0.482716510479974 no 1759 0.484052230787964 2476 260807 SGTC_2911 7942208 15.64 µM -0.0401381571989183 0.482653968164442 no 1760 0.483991490627293 2508 1243384 SGTC_1663 st014140 55.4 µM -0.040424792844653 0.482536319907853 no 1761 0.483877232284778 2476 4207120 SGTC_333 3486-0131 40.1 µM -0.0409895189254033 0.482304535195382 no 1762 0.483652125763514 2564 6744690 SGTC_2812 7970281 58.44 µM -0.0415937861599711 0.482056527939771 no 1763 0.483411263441392 2516 2233435 SGTC_1169 aniline yellow 25.8 µM -0.0417846374640677 0.481978198954986 no 1764 0.483335190922418 2509 6051 A DNA damaging agent. SGTC_1373 2887-0003 58.5 µM -0.0433805354171358 0.481323239772451 no 1765 0.482699096790011 2528 776948 SGTC_2467 5474540 200 µM -0.0438367697709868 0.481136009620634 no 1766 0.482517258602458 2487 5413519 SGTC_2003 4023581 200 µM -0.0438778689539254 0.48111914347878 no 1767 0.482500878161871 2545 16641307 SGTC_508 roscovitine 141 µM -0.0447024654609466 0.480780755572006 no 1768 0.482172234255429 2476 160355 A CDKinase inhibitor. SGTC_1201 1889-3372 45.9 µM -0.0450658937432437 0.480631620666634 no 1769 0.482027393319549 2535 5392199 SGTC_459 nigericin 15.3 µM -0.04556557992642 0.480426575970835 no 1770 0.481828251951217 2523 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification. SGTC_450 aminopyrene 156 nM -0.0460927802436472 0.480210246549828 no 1771 0.481618150212544 2473 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1 SGTC_3041 9091929 49.47 µM -0.0463244623639438 0.480115180808396 no 1772 0.481525821044301 2524 25236887 SGTC_2923 7992654 58.14 µM -0.0464227254296046 0.480074861028359 no 1773 0.481486661881558 2505 2985126 SGTC_485 niflumic acid 177 µM -0.0465526453268561 0.480021551975914 no 1774 0.481434887316885 2568 4488 A COX2 inhibitor. SGTC_2686 alizarin 95.37 µM -0.0466115096945431 0.479997398721055 no 1775 0.481411429296282 2527 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1 SGTC_2337 9009472 200 µM -0.0468822025434285 0.479886328851564 no 1776 0.481303556404223 2507 5742383 SGTC_2294 7971431 200 µM -0.0486971120908579 0.47914168142488 no 1777 0.480580338682394 2542 5741572 SGTC_1485 3909-9022 254 µM -0.049010814079314 0.479012978526961 no 1778 0.480455338954338 2484 714516 SGTC_2356 9061756 188.97 µM -0.0494032412754566 0.478851980024438 no 1779 0.480298972576883 2482 20104043 SGTC_1539 benzyladenosine 56 µM -0.0510609056211468 0.4781719394539 no 1780 0.479638494063969 2495 92208 A nucleotide analog. SGTC_1503 4585-0012 61.3 µM -0.0512548533080063 0.478092378428407 no 1781 0.479561221314166 2613 2922052 SGTC_1011 4112-3381 17.4 µM -0.0518495781395727 0.477848416461601 no 1782 0.479324275503682 2633 2877139 SGTC_2997 9067075 71.4286 µM -0.0520159614606222 0.477780165871247 no 1783 0.479257987612175 2544 27209819 SGTC_1793 st048256 72.231 µM -0.0520929670593921 0.477748578324733 no 1784 0.479227308416381 2503 672022 SGTC_583 1488-1091 88.9 µM -0.0525091587326701 0.477577859736041 no 1785 0.479061498895288 2481 4303273 SGTC_3197 9113331 49.47 µM -0.0530294896033724 0.477364429849546 no 1786 0.478854205728952 2536 16610459 YLR208W | YDL195W SEC13 | SEC31 SGTC_1694 st024011 44.9 µM -0.0531062244329968 0.477332955220932 no 1787 0.478823636036508 2500 2787533 SGTC_2973 9094665 17.96 µM -0.0536842162218736 0.47709588259974 no 1788 0.478593379148366 2564 25237061 YIL048W NEO1 SGTC_2276 7947513 42.08 µM -0.0542098140095991 0.476880307254906 no 1789 0.478384000867301 2574 2105100 SGTC_772 k072-0172 35.3 µM -0.0549286064672139 0.476585503562866 no 1790 0.478097670805453 2522 5861980 SGTC_424 splitomicin 100 mM -0.055332105125037 0.476420019265509 no 1791 0.477936942572709 2590 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_587 k089-0003 57 µM -0.0555509005344827 0.476330287816576 no 1792 0.477849789879518 2498 9659696 SGTC_3082 9117008 49.47 µM -0.0587247841803721 0.47502876535398 no 1793 0.476585659239483 2554 41448529 SGTC_1876 myriocin 605 nM -0.0588347235196591 0.474983686946395 no 1794 0.47654187549188 2529 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1 SGTC_2299 7976368 114.88 µM -0.0589210099594014 0.474948307157248 no 1795 0.476507511797149 2547 2979718 SGTC_302 1094-0063 18.9 µM -0.0590325360956605 0.474902578698179 no 1796 0.476463096617023 2515 5440289 SGTC_582 0987-0078 156 µM -0.0594063285862893 0.474749316997318 no 1797 0.476314236240552 2518 1625765 SGTC_2296 7971656 126.45 µM -0.0603647487974543 0.47435636445415 no 1798 0.475932566910587 2539 666570 SGTC_619 1652-1634 108 µM -0.0610670552560133 0.474068434434289 no 1799 0.475652903130748 2546 5400454 SGTC_1333 1482-0047 286 µM -0.0612447202352371 0.473995597887111 no 1800 0.475582157478534 2514 3811116 SGTC_377 3970-0964 33.1 µM -0.0614772705923535 0.473900261531617 no 1801 0.475489557800009 2523 16481235 SGTC_2472 5377652 49.4 µM -0.0627904061463612 0.473361956625581 no 1802 0.474966702790488 2558 1610903 SGTC_7 0192-1582 4.227 µM -0.0636468539406393 0.473010891790885 no 1803 0.47462571164785 2522 252616 SGTC_1490 4089-0339 670 nM -0.064823118726784 0.47252876562174 no 1804 0.474157417038954 2520 742542 SGTC_2281 7943571 200 µM -0.0653615374793049 0.472308092496332 no 1805 0.473943073605691 2544 1244024 SGTC_453 enantio-paf c16 10 µM -0.0661742470105512 0.471975016294436 no 1806 0.473619549865356 2537 13871343 A lipid and platelet activating factor SGTC_2544 sphondin 68.51 µM -0.0668916994950134 0.47168099597266 no 1807 0.473333960541339 2650 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31 SGTC_2121 5257820 149.641 µM -0.0679364527657554 0.471252871648289 no 1808 0.472918110330775 2537 791256 SGTC_1853 st056710 91.2 µM -0.0694483297290668 0.470633385942952 no 1809 0.472316380096139 2663 269167 SGTC_2837 9008476 45.46 µM -0.069544420580447 0.470594015476262 no 1810 0.472278137854534 2638 2992805 SGTC_1975 st070967 30.8 µM -0.0705843900822908 0.470167936309359 no 1811 0.471864267166182 2540 261391 SGTC_511 blebbistatin 171 µM -0.0734087791399096 0.469010947899521 no 1812 0.470740415851445 2665 3476986 A myosin inhibitor. SGTC_3243 9134147 49.47 µM -0.0742538631212826 0.46866481641111 no 1813 0.470404193764768 2538 24282180 SGTC_2118 5526350 200 µM -0.0743418002899873 0.46862880025434 no 1814 0.470369208605522 2659 743594 SGTC_2130 NSC 7 2.4545 µM -0.0746105977973118 0.46851871127585 no 1815 0.470262270902843 2572 21448 SGTC_1361 1608-0041 5.61 µM -0.0757636676444127 0.468046486241231 no 1816 0.469803561015616 2546 X1361 SGTC_2842 9000675 19.48 µM -0.0760149511962918 0.467943582214258 no 1817 0.46970360163988 2615 2989072 SGTC_2817 7995342 71.43 µM -0.0765734603970977 0.467714872793177 no 1818 0.469481436241222 2546 18879975 SGTC_500 h-89 112 µM -0.0777261447260823 0.467242882537933 no 1819 0.46902294826545 2642 449241 Protein kinase A inhibitor; also known to inhibit several other kinases. SGTC_336 4111-0029 111 µM -0.0780884181416806 0.467094551733292 no 1820 0.468878860022875 2590 3131175 SGTC_61 0978-8327 98.565 µM -0.0806980345284612 0.46602619530359 no 1821 0.467841049969687 2556 6150059 YHR072W ERG7 SGTC_1725 st036284 20.55 µM -0.0818763820238492 0.465543868860692 no 1822 0.467372507891421 2618 707914 SGTC_45 0kpi-0036 14.9 µM -0.0820026129438961 0.465492202447353 no 1823 0.467322317813614 2615 2795021 SGTC_2059 5238311 157 µM -0.0823014328562059 0.465369897545683 no 1824 0.467203507516688 2566 703021 SGTC_388 3',4'-dichloroisocoumarin 16.7 µM -0.0823766593836301 0.465339108368711 no 1825 0.467173598035272 2656 1609 A potent and irreversible inhibitor of serine proteases. SGTC_3221 9128209 49.47 µM -0.0835427257217182 0.464861880197146 no 1826 0.466710002948111 2600 16460723 SGTC_288 1315-0019 35.1 µM -0.0837429666585968 0.464779933993566 no 1827 0.466630397325341 2600 6811474 SGTC_2097 5376186 200 µM -0.0838479896224925 0.464736955201228 no 1828 0.466588646064306 2575 742755 SGTC_2914 7968218 45.32 µM -0.0845912441456618 0.464432803207368 no 1829 0.466293180138609 2618 2977111 SGTC_537 1334-0398 209 µM -0.0847893011665944 0.464351758511457 no 1830 0.466214449670905 2550 5846986 SGTC_1005 4092-0690 4.4 µM -0.0848451060040528 0.464328923505693 no 1831 0.466192266697163 2593 1529343 SGTC_1237 0330-0133 46.1 µM -0.0851981931385554 0.464184445088407 no 1832 0.466051913513314 2575 X1237 YHR072W ERG7 SGTC_1893 st059353 36.1 µM -0.0853901006471179 0.464105921145243 no 1833 0.465975631479013 2608 3112488 SGTC_2445 5742597 35.57 µM -0.0858135314026983 0.463932668400318 no 1834 0.465807324827946 2578 1774255 SGTC_589 1227-0070 34.1 µM -0.0905054691527853 0.462013360129373 no 1835 0.463942774018249 2651 2841384 SGTC_2146 5545642 200 µM -0.0914368563363499 0.461632465847927 no 1836 0.463572738637476 2575 825326 SGTC_2363 9053361 176 µM -0.0915131762961047 0.461601256069316 no 1837 0.463542418499025 2656 6469797 YMR079W SEC14 SGTC_1337 1486-1011 40.3 µM -0.0927293433132014 0.461103956822939 no 1838 0.463059292423696 2572 X1337 SGTC_2185 6113692 200 µM -0.0928260504731988 0.461064415185238 no 1839 0.463020877536994 2659 874150 SGTC_279 1273-0055 2.93 µM -0.0938258397152623 0.460655643846217 no 1840 0.4626237525506 2594 2847562 SGTC_3180 9109287 49.47 µM -0.0942016721491507 0.46050199266145 no 1841 0.462474478249969 2663 18891271 SGTC_2138 5575593 77.673 µM -0.0960852331792573 0.459732027655329 no 1842 0.461726439627378 2577 762213 SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM -0.0964275664199156 0.459592104272154 no 1843 0.461590499647316 2645 6728940 SGTC_2000 st075254 36.4 µM -0.0971232663839932 0.459307763180147 no 1844 0.461314252151602 2581 17234175 SGTC_1874 staurosporine 7.6 µM -0.0975162107042823 0.459147171215031 no 1845 0.461158230651668 2664 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1 SGTC_2188 6126565 140.678 µM -0.0997935627689721 0.458216574894705 no 1846 0.460254109352979 2599 874518 SGTC_264 promethazine 12.5 mM -0.0998015062972602 0.45821332932174 no 1847 0.460250956085411 2569 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3 SGTC_1979 st071809 45.3 µM -0.100780773938175 0.457813240796996 no 1848 0.459862244649653 2724 4976333 SGTC_1342 1486-1464 234 µM -0.101931263169898 0.457343252802168 no 1849 0.459405617386783 2581 3253938 SGTC_2191 5911152 200 µM -0.102218187000132 0.457226050407277 no 1850 0.459291746114565 2597 2875902 SGTC_1967 st070177 51.4 µM -0.102871210615735 0.456959317777175 no 1851 0.459032593525552 2693 5729214 SGTC_1881 5652484 16 µM -0.103349025870243 0.456764162656831 no 1852 0.458842983442307 2607 2255129 SGTC_2737 bleomycin 30.5 nM -0.103477574158926 0.45671166117865 no 1853 0.458791973583092 2604 16211318 Bleomycin acts by induction of DNA strand breaks. SGTC_96 0929-0093 37.281 µM -0.103961102758166 0.456514186006825 no 1854 0.458600108377712 2576 6991579 SGTC_1730 st033808 45.1 µM -0.104591285880299 0.456256832620054 no 1855 0.458350064819564 2598 1045166 SGTC_1010 4112-3296 15.2 µM -0.104885202935815 0.456136809412672 no 1856 0.458233450273642 2602 704384 SGTC_1684 st024538 14.6195 µM -0.105479023195845 0.455894330732396 no 1857 0.457997857095797 2595 6732859 SGTC_1621 st003705 32.4 µM -0.107183910791365 0.455198253934866 no 1858 0.457321539611052 2672 24207032 SGTC_1412 3909-8563 178 µM -0.107219353944741 0.455183784546086 no 1859 0.457307480854111 2627 23767530 SGTC_840 0245-0196 390 µM -0.107791844723825 0.454950077934567 no 1860 0.457080406082126 2712 3827528 SGTC_2939 9044578 71.43 µM -0.107947104482799 0.454886699279778 no 1861 0.457018825713255 2610 2653634 SGTC_1355 1499-0035 1.68 µM -0.107955473396446 0.454883283034445 no 1862 0.45701550639701 2608 1548538 SGTC_3113 9123498 49.47 µM -0.108842426767727 0.454521241828787 no 1863 0.456663736000502 2582 8897275 SGTC_2780 5215298 71.43 µM -0.108936858748631 0.454482698315298 no 1864 0.45662628577296 2641 2834131 SGTC_717 1532-0246 73.2 µM -0.11035811535758 0.453902647837934 no 1865 0.4560626846384 2656 9561992 SGTC_1415 3966-0071 78.1 µM -0.111071955237383 0.453611348886573 no 1866 0.455779643793495 2620 2893185 SGTC_1386 3228-0095 33.8 µM -0.11207199698514 0.453203300616296 no 1867 0.455383160344047 2693 870181 SGTC_74 000s-0487 160.283 µM -0.113662423043562 0.45255445904263 no 1868 0.45475270074243 2591 677548 SGTC_2379 9035213 200 µM -0.114148817643787 0.452356051242104 no 1869 0.454559912105959 2598 646551 SGTC_2884 9058502 51.95 µM -0.114230194206132 0.452322857657417 no 1870 0.454527658522742 2685 6471554 SGTC_1582 3',3',6'-trihydroxyflavone 74 µM -0.114405112418564 0.452251509464322 no 1871 0.454458330741489 2603 688803 SGTC_744 1594-0068 283 µM -0.114798151136053 0.452091196724896 no 1872 0.454302557274337 2622 668392 SGTC_932 2857-0803 154 µM -0.115778572839763 0.451691336152246 no 1873 0.453914016346317 2838 674898 SGTC_2958 9077254 16.72 µM -0.116092766714926 0.451563203945753 no 1874 0.453789510689 2750 16457351 SGTC_2244 6635614 200 µM -0.116239636399975 0.451503310374326 no 1875 0.453731312172189 2595 836499 SGTC_2342 7990637 118.86 µM -0.116361481483469 0.451453622692571 no 1876 0.453683030646982 2695 2033102 YER133W GLC7 SGTC_2259 7964009 200 µM -0.117765424418865 0.450881158392715 no 1877 0.453126763088251 2791 313134 SGTC_2377 9073351 62.6 µM -0.117806836144174 0.450864274113252 no 1878 0.453110356405425 2606 7337946 YHR072W ERG7 SGTC_2477 5967686 25.23 µM -0.117810920960688 0.45086260866745 no 1879 0.453108738068858 2623 776118 SGTC_2649 anisomycin 9.56 µM -0.118142046773918 0.450727606194349 no 1880 0.452977554105247 2668 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_672 1441-0018 53.7 µM -0.119489591016006 0.450178261281505 no 1881 0.452443743060392 2618 251141 SGTC_627 1391-0720 175 µM -0.119607340797047 0.450130263485849 no 1882 0.452397102179834 2685 997839 SGTC_3001 9076041 71.4286 µM -0.119951736928585 0.449989883081752 no 1883 0.452260690082313 2638 16004211 SGTC_1217 1183-1422 255 µM -0.12048026645553 0.449774459654275 no 1884 0.452051355428693 2731 2849664 SGTC_2625 euphol 100 µM -0.120576762527384 0.449735130402096 no 1885 0.452013137673382 2705 6708538 A triterpene alcohol. SGTC_3196 9111891 49.47 µM -0.120622962704297 0.449716300604052 no 1886 0.451994840017996 2570 18891510 SGTC_307 1501-1223 22.3 µM -0.121194689176447 0.44948329152843 no 1887 0.451768415267407 2668 2830329 SGTC_2723 salbutamol 83.58 µM -0.122446333653795 0.448973240464097 no 1888 0.451272772801693 2706 9884233 β2-adrenoceptor agonist SGTC_1797 st048695 56.8 µM -0.122670182629267 0.448882029808066 no 1889 0.451184138156607 2688 592262 YIL048W NEO1 SGTC_2583 asiatic acid 100 µM -0.123032227193727 0.448734514986009 no 1890 0.45104078910697 2746 5320556 A kinase inhibitor; arrests cells at G2/M. SGTC_2587 piperic acid 92.2 µM -0.123707215396538 0.448459510421051 no 1891 0.45077354924423 2685 5370536 SGTC_1800 st050079 29.0735 µM -0.125074628023729 0.447902473440789 no 1892 0.450232234723405 2690 3645560 SGTC_2297 7971671 152.32 µM -0.126618725304823 0.447273584736519 no 1893 0.449621087789978 2737 909016 SGTC_2190 6049624 200 µM -0.12798476140681 0.446717328245585 no 1894 0.449080516247336 2608 2265554 SGTC_1897 st060201 15 µM -0.130753676347931 0.445590135412351 no 1895 0.447985084603648 2667 611878 SGTC_1376 2910-0861 41.3 µM -0.131488434279679 0.445291097507743 no 1896 0.447694467623864 2646 1112859 SGTC_1056 3448-1962 115 µM -0.131503453426425 0.445284985214323 no 1897 0.447688527430344 2739 715507 SGTC_2260 7964312 200 µM -0.133468192204359 0.444485514525934 no 1898 0.446911559061514 2846 231951 SGTC_1690 st023502 41.2 µM -0.13365629854622 0.444408984079112 no 1899 0.446837181858799 2720 24207482 SGTC_2758 dehydroepiandrosterone 69.35 µM -0.135026681275332 0.443851511095685 no 1900 0.446295389451274 2704 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem] SGTC_526 4469-0568 170 µM -0.135201045388396 0.443780587553955 no 1901 0.446226460291718 2624 2901964 SGTC_1440 4100-1550 40 µM -0.135850533625479 0.443516420579952 no 1902 0.445969720636958 2647 742806 SGTC_2976 9009005 19.48 µM -0.135866517485957 0.44350991976501 no 1903 0.445963402577012 2772 2993148 SGTC_2004 4023728 41.89 µM -0.136110937108499 0.443410513463817 no 1904 0.445866790716812 2703 360084 YDR527W RBA50 SGTC_3083 9117465 49.47 µM -0.136930340071526 0.443077285476617 no 1905 0.445542928399743 2732 16420915 SGTC_456 gingerol 170 µM -0.137245296856238 0.442949212166625 no 1906 0.445418453963209 2804 442793 A herb. SGTC_2629 bisabolol 100 µM -0.13756609164604 0.442818771031085 no 1907 0.445291677812962 2788 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer. SGTC_2979 9012552 45.46 µM -0.138210992830819 0.442556560967189 no 1908 0.445036833727672 2705 17100905 SGTC_1210 3013-0140 750 nM -0.138836518919295 0.442302252651364 no 1909 0.444789667753156 2805 905973 SGTC_1906 st060206 94.7 µM -0.139136822229376 0.442180172452328 no 1910 0.444671015637555 2698 5133468 SGTC_947 3447-0010 211 µM -0.139566561794089 0.442005482994214 no 1911 0.444501230901876 2617 748350 SGTC_1119 parthenolide 318.541 nM -0.14059484246571 0.441587531965523 no 1912 0.444095011440968 2839 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs. SGTC_1882 5615643 20 µM -0.140655756501261 0.441562775115384 no 1913 0.444070949356424 2628 2253075 SGTC_2600 tangeritin 87.95 µM -0.141268809188497 0.441313629280476 no 1914 0.443828794566151 2675 68077 A bioactive flavone. SGTC_1306 1185-0270 9.02 µM -0.145309334400041 0.439672137188494 no 1915 0.442233322581105 2753 1548076 SGTC_287 k060-0039 29.6 µM -0.145648760882213 0.439534289574502 no 1916 0.442099336387528 2781 5861974 SGTC_2802 7925815 54.55 µM -0.146448312043218 0.439209605493632 no 1917 0.441783745449621 2679 1262923 SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM -0.146755845948641 0.439084732100912 no 1918 0.441662368532579 2844 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis. SGTC_1794 st048918 76.9 µM -0.147075995839411 0.438954742458534 no 1919 0.441536018181369 2622 672303 SGTC_2319 6033012 152.6 µM -0.14818980195888 0.438502557987622 no 1920 0.441096489908279 2704 847246 SGTC_941 3237-0776 460 µM -0.148458484052394 0.438393490072909 no 1921 0.440990473878144 2818 760008 SGTC_543 3844-1095 191 µM -0.148468315711018 0.43838949913082 no 1922 0.440986594602575 2774 4230703 SGTC_753 1322-0200 289 µM -0.149188939846111 0.438096994954055 no 1923 0.440702273524485 2813 5403907 SGTC_3112 9123419 49.47 µM -0.149305733776623 0.438049591017714 no 1924 0.440656195544112 2656 17015854 SGTC_2438 5259590 200 µM -0.14942187272266 0.438002453805808 no 1925 0.440610376767429 2795 1201127 SGTC_1900 st060200 72.8 µM -0.150427496349235 0.43759433908399 no 1926 0.440213674567891 2652 688945 SGTC_1920 st075728 45.7 µM -0.151063060536109 0.437336440705971 no 1927 0.439962985732971 2809 3400306 SGTC_2321 7390090 138.78 µM -0.151207066807451 0.437278009731104 no 1928 0.439906187943238 2757 649046 SGTC_2223 6903751 107.57 µM -0.151525466751851 0.437148822860284 no 1929 0.439780611602213 2778 5598863 SGTC_1039 k821-0043 94 µM -0.152391321183507 0.436797546976986 no 1930 0.439439150912687 2770 15992768 SGTC_294 k038-0071 157 µM -0.152545696054226 0.436734922542625 no 1931 0.439378275947306 2726 24152826 SGTC_213 1246-0773 967 nM -0.153564904922113 0.436321505351778 no 1932 0.438976405226191 2703 6251622 SGTC_2699 st077704 54.6 µM -0.153566427775945 0.436320887695233 no 1933 0.438975804816864 2728 645852 SGTC_161 4065-0411 162.148 µM -0.153583696301291 0.436313883739288 no 1934 0.438968996436109 2800 1906281 YLR208W SEC13 SGTC_138 0850-0259 40.9225 µM -0.154389222851542 0.435987191765341 no 1935 0.438651425349274 2717 6813004 SGTC_2729 fluphenazine 10.66 µM -0.154538916315104 0.435926486401365 no 1936 0.438592414487881 2703 3372 An atypical antipsychotic. SGTC_1248 0469-0687 58.6 µM -0.154861101143497 0.435795835536611 no 1937 0.438465410206403 2779 4017482 SGTC_231 b-estradiol 524 µM -0.155781814811757 0.435422510762169 no 1938 0.438102502644887 2688 450 A steroid. SGTC_1451 4152-0210 104 µM -0.156432902829281 0.435158546696302 no 1939 0.437845901854486 2772 659563 SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM -0.15643891814216 0.43515610810303 no 1940 0.437843531276659 2800 5024745 SGTC_786 4544-0069 423 µM -0.156754043312439 0.435028360573283 no 1941 0.437719346553533 2815 748821 YLR208W SEC13 SGTC_1750 st081859 2.357 µM -0.158351872949784 0.434380726448447 no 1942 0.437089767512965 2699 5291695 SGTC_3193 9111931 49.47 µM -0.159163702350562 0.434051742176003 no 1943 0.436769950293644 2699 17087244 SGTC_2982 9019404 25.97 µM -0.160497240839131 0.433511440693272 no 1944 0.436244697472485 2711 22333232 SGTC_2052 5265182 7.135 µM -0.160777257583959 0.433398003801069 no 1945 0.436134419003284 2816 1239884 SGTC_31 0508-1974 57.237 µM -0.161266269773418 0.433199914442835 no 1946 0.435941844160975 2740 6810525 SGTC_1332 1480-0653 17.5 µM -0.162370669829322 0.43275260521212 no 1947 0.435506983204635 2653 5749438 SGTC_2605 digitonin 300 nM -0.163382031801505 0.432343054258821 no 1948 0.4351088246672 2703 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_278 4092-0821 23.9 µM -0.163411578066907 0.432331090591522 no 1949 0.435097193718202 2778 877900 SGTC_1630 st005209 31.3 µM -0.163651107691284 0.432234104221291 no 1950 0.435002904455854 2678 3367314 SGTC_3163 9099914 49.47 µM -0.164690573166007 0.431813268453211 no 1951 0.434593768592975 2744 16268368 SGTC_660 4031-1742 102 µM -0.166129878310053 0.431230682283702 no 1952 0.434027370685068 2685 6738706 SGTC_2919 7978188 46.38 µM -0.166631304864967 0.431027755404534 no 1953 0.433830080167313 2800 2980291 SGTC_982 1491-0518 27.5 µM -0.167219909624968 0.430789570817486 no 1954 0.433598509682704 2735 3091256 SGTC_673 1082-0474 110 µM -0.167696575654814 0.430596701759207 no 1955 0.433410995136028 2720 3098046 SGTC_19 0279-0214 38.434 µM -0.167706842967738 0.430592547571335 no 1956 0.433406956266303 2692 3566274 YBR002C RER2 SGTC_2694 st077685 81.9 µM -0.167934331858473 0.430500506804795 no 1957 0.433317470373085 2692 2838096 SGTC_328 k915-0120 63.5 µM -0.168181097998621 0.430400670837239 no 1958 0.433220405373426 2834 6624543 SGTC_1277 0873-0036 22 µM -0.168549494795507 0.430251634152721 no 1959 0.433075504680058 2773 5965735 SGTC_2119 5528445 120.635 µM -0.169436693397541 0.429892754536099 no 1960 0.432726581786531 2831 791935 SGTC_2204 7233102 200 µM -0.170013562212577 0.42965943709405 no 1961 0.432499735411244 2719 2172480 SGTC_1129 3453-1384 223 µM -0.170382738681453 0.429510134733419 no 1962 0.432354573097537 2942 1084452 SGTC_2987 9018338 71.43 µM -0.171019002570561 0.429252840541805 no 1963 0.432104411911545 2672 5055682 SGTC_2170 morpholine 200 µM -0.171758911504486 0.428953671876696 no 1964 0.431813534627558 2822 121171 Reacts with secondary amines. SGTC_2187 6125751 200 µM -0.173056846134832 0.428428974398299 no 1965 0.431303372437687 2754 874498 SGTC_924 2046-0044 21.3 µM -0.173957771374367 0.428064844546206 no 1966 0.430949324854432 2695 3623589 SGTC_3130 9127414 49.47 µM -0.174749470557136 0.427744911488236 no 1967 0.43063824695888 2695 1494646 SGTC_2506 ethyl hematommate 54.16 µM -0.175261581369354 0.427537987998062 no 1968 0.430437049054839 2782 3940691 An allergen. SGTC_1698 5-fluorocytosine 1.055 µM -0.175271450906857 0.427534000308405 no 1969 0.430433171691835 2792 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_581 0958-0271 211 µM -0.175523677416182 0.427432093178708 no 1970 0.430334083840706 2704 4591145 SGTC_411 enrofloxacin 100 µM -0.177083753599042 0.426801883112068 no 1971 0.429721301498726 2874 71188 A bacterial gyrase inhibitor. SGTC_2642 cholecalciferol 100 µM -0.178123036252949 0.426382156937019 no 1972 0.429313175503503 2814 9821465 A vitamin D precursor, similar to steriods. SGTC_1057 3448-5381 134 µM -0.178393659235374 0.426272876414448 no 1973 0.429206914316888 2854 5497911 SGTC_2890 9046729 58.44 µM -0.179156233499443 0.425964971055113 no 1974 0.428907514128304 2769 903329 SGTC_1414 3917-0015 5.4 µM -0.179161463115113 0.42596285964366 no 1975 0.428905461029405 2746 6618702 SGTC_364 0083-0097 67.7 µM -0.179422748915215 0.425857370497314 no 1976 0.428802885083264 2857 5207356 SGTC_1808 st050063 61.5 µM -0.180250260157646 0.425523313700854 no 1977 0.428478051321832 2821 4011993 SGTC_2028 5153890 36.43 µM -0.180624379120449 0.425372303698919 no 1978 0.428331209424858 2730 2830968 YPR165W RHO1 SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM -0.181758615691272 0.42491454555349 no 1979 0.427886081677198 2868 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_2031 5180455 200 µM -0.181893876714437 0.424859963301562 no 1980 0.427833005006206 2725 29949 SGTC_1074 carmofur 3.8 µM -0.181977857855711 0.424826074885929 no 1981 0.427800051310964 2722 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_1943 st076331 65.2 µM -0.18228817686686 0.424700858503052 no 1982 0.427678288365874 2791 24208415 SGTC_2093 5331342 194.4 µM -0.182745324366615 0.424516409410091 no 1983 0.427498925422136 2854 33839 SGTC_2340 7987427 183.45 µM -0.184123222963203 0.423960557385148 no 1984 0.426958394316343 2851 2239331 SGTC_2846 9008642 19.48 µM -0.184699533999634 0.423728115073864 no 1985 0.426732355851339 2861 2992898 SGTC_1300 1094-0077 113 µM -0.186275375164154 0.423092670102536 no 1986 0.426114408630655 2741 5532636 SGTC_2581 avocatin a 64 µM -0.186590176958396 0.422965752789026 no 1987 0.425990984568086 2801 6710728 A skin care supplement. SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM -0.188318822074944 0.422268965044987 no 1988 0.425313365717224 2753 6708561 SGTC_554 4483-2211 187 µM -0.190450111936216 0.421410212967551 no 1989 0.424478216267752 2854 747107 SGTC_2420 aureobasidin a 50 nM -0.191131092365186 0.421135906831273 no 1990 0.42421144423379 3042 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1 SGTC_3037 9091026 49.47 µM -0.192727223321174 0.420493118584104 no 1991 0.423586301004087 2813 25236398 YIL048W NEO1 SGTC_2553 4-methylesculetin 85.09 µM -0.192749987768799 0.420483952494795 no 1992 0.423577386430796 2782 5319502 SGTC_384 k007-0144 5.16 µM -0.193034966478989 0.420369209661521 no 1993 0.423465791883872 2818 6824886 SGTC_1600 coumarin 106 71.1 µM -0.193932120461855 0.420008026939626 no 1994 0.423114516317322 2906 100336 A hepatotoxic, DNA x-linker. SGTC_1121 fusaric acid 630.51 nM -0.197289309200684 0.418657065710461 no 1995 0.421800572478982 2769 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler. SGTC_987 1497-1013 404 µM -0.198094800322948 0.418333071269668 no 1996 0.421485446482489 2743 1676435 SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM -0.19986940456977 0.417619464140492 no 1997 0.420791359616545 2954 688798 SGTC_1978 st071761 42 µM -0.200247455306146 0.417467476644688 no 1998 0.420643527366807 2786 5147680 SGTC_2310 7668677 200 µM -0.20084234663094 0.417228337839933 no 1999 0.420410924848814 2957 2197143 SGTC_1997 st073024 93.8 µM -0.201264707247614 0.417058572781814 no 2000 0.42024579870491 2849 686268 SGTC_918 glabranin 770.725 nM -0.202257272979941 0.416659678469496 no 2001 0.419857800420393 2814 124049 Also referred to as licorice root. SGTC_3047 9092122 49.47 µM -0.203149135274922 0.416301328226743 no 2002 0.419509233971429 2828 17173831 SGTC_822 1487-0950 154 µM -0.203821896111429 0.416031058953245 no 2003 0.419246340691938 2835 1958375 SGTC_1290 0986-0249 10.2 µM -0.204386408071275 0.415804307302345 no 2004 0.419025775397357 2834 53329 SGTC_1220 1838-0075 193 µM -0.205551459345868 0.415336421325442 no 2005 0.418570648780848 2789 5529645 SGTC_751 0833-0568 350 µM -0.208486538983968 0.414158223369408 no 2006 0.417424546027279 2850 6954252 SGTC_1158 4092-0494 91.8 µM -0.209212395115824 0.413866969299535 no 2007 0.417141218313881 2906 1148199 SGTC_3336 9143619 71.43 µM -0.209526925548937 0.413740776803402 no 2008 0.417018459143259 2780 45595730 SGTC_177 1327-0068 8.361 µM -0.210360709008652 0.413406298365817 no 2009 0.416693078091032 2773 15389900 YOR207C | YLR033W RET1 | RSC58 SGTC_2595 hexamethylquercetagetin 100 µM -0.212077259542083 0.412717889437764 no 2010 0.416023380219873 2877 386331 SGTC_2449 5812982 45.77 µM -0.213423571151451 0.412178149552728 no 2011 0.415498298442866 2806 776185 SGTC_2071 5230951 39.92 µM -0.215210468265012 0.411462034409581 no 2012 0.414801614826333 2811 1799272 SGTC_399 oxolinic acid 75 µM -0.216712964612421 0.4108601235288 no 2013 0.414216021901283 2777 4628 A DNA gyrase inhibitor. SGTC_2850 9015429 58.44 µM -0.216952007387475 0.410764380579152 no 2014 0.414122873325067 2852 6457570 SGTC_1506 4226-2149 212 µM -0.217003630279517 0.410743704944278 no 2015 0.414102757898772 2893 991114 SGTC_2180 6301957 200 µM -0.217095788180606 0.410706795131448 no 2016 0.414066848121696 2864 845462 SGTC_544 k015-0020 52.4 µM -0.217179385804381 0.410673314446883 no 2017 0.414034274519993 2819 3008304 SGTC_41 0478-0632 82.643 µM -0.217254891353919 0.410643075181604 no 2018 0.414004854482744 2796 3750424 SGTC_3276 9139060 49.47 µM -0.217940184661913 0.41036864593909 no 2019 0.413737858386536 2769 4870619 SGTC_3034 9090421 49.47 µM -0.219699777923448 0.409664209034289 no 2020 0.413052488816015 2773 17173761 SGTC_659 k018-0002 107 µM -0.219712670189803 0.409659048807598 no 2021 0.413047468194777 2906 6797879 YHR007C ERG11 SGTC_1520 flindersine 88 µM -0.220955040372534 0.4091618543313 no 2022 0.412563720164031 3079 68230 Flindersine is a natural alkaloid of the quinoline subtype. SGTC_1068 loratadine 26.9 µM -0.221083976554827 0.409110262640714 no 2023 0.412513523216153 2844 3957 A H1 histamine antagonist. SGTC_1688 st021091 57.6 µM -0.221666033658609 0.408877381682228 no 2024 0.412286936762413 2864 3656366 SGTC_2893 9048488 25.97 µM -0.22257038485751 0.408515614744382 no 2025 0.41193494387673 2831 6467338 SGTC_943 3253-1379 105 µM -0.22318308676347 0.408270560329867 no 2026 0.411696507392174 2962 668464 SGTC_2444 5485484 36.41 µM -0.223222749558367 0.408254698152657 no 2027 0.411681073509172 2925 6790631 SGTC_1813 st051246 8.6015 µM -0.225297958252401 0.40742497884117 no 2028 0.410873743961564 2875 5291959 SGTC_3024 9090631 49.47 µM -0.225460845830998 0.407359869918284 no 2029 0.41081039086478 2864 25236383 SGTC_228 caffeine 993.056 µM -0.225687054088462 0.40726945489349 no 2030 0.41072241383726 2934 2519 Caffeine is a phosphodiesterase inhibitor. SGTC_2937 9044753 11.33 µM -0.22757754636582 0.406514022229939 no 2031 0.409987338668706 2787 6465530 YGL099W LSG1 SGTC_529 4076-0302 30.3 µM -0.22781173353621 0.406420466187966 no 2032 0.409896302242975 2816 5816522 SGTC_1106 tegaserod maleate 11.7 µM -0.227938223494036 0.406369936607145 no 2033 0.409847133363937 2856 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation. SGTC_452 diindolylmethane 8 µM -0.228284822801132 0.406231486827645 no 2034 0.409712411362495 2912 3071 Inhibits expression of several cancer promoting factors. SGTC_449 xestospongin c 11.1929 µM -0.228999823843307 0.405945915302343 no 2035 0.409434526520378 2936 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1 SGTC_2907 7721985 69.9 µM -0.22914867948346 0.405886468625113 no 2036 0.40937667955834 2865 3267881 SGTC_805 3852-0218 479 µM -0.230809013363074 0.405223548554195 no 2037 0.408731589316699 2796 6615355 SGTC_2558 carylophyllene oxide 100 µM -0.232454107454206 0.404566981333596 no 2038 0.408092663963108 2803 6708694 An oxygenated terpenoid and antifungal agent. SGTC_251 melphalan 456.522 µM -0.233006959844278 0.404346394743748 no 2039 0.407878000665215 2884 460612 A DNA alkylator. SGTC_128 0906-2981 13.371 µM -0.233116389909966 0.404302736049718 no 2040 0.407835514084853 2970 6740226 SGTC_2716 st080858 38.6235 µM -0.233141846265906 0.40429258004229 no 2041 0.407825630726898 2954 5296050 SGTC_1476 4112-3294 3.34 µM -0.233685703786124 0.404075619354171 no 2042 0.407614493610928 2933 704369 SGTC_1243 0416-0003 5.65 µM -0.234395787036484 0.403792390772257 no 2043 0.407338864508862 2874 2141977 SGTC_3119 9125183 49.47 µM -0.235822093087829 0.403223637291256 no 2044 0.406785361891948 2883 22695334 SGTC_3050 9093513 49.47 µM -0.235832060987728 0.403219663212481 no 2045 0.40678149433054 2826 25236664 SGTC_2828 7998861 71.43 µM -0.236327669855516 0.40302208267987 no 2046 0.406589208753318 2935 2988188 SGTC_713 1488-1073 324 µM -0.236646190891972 0.402895113441748 no 2047 0.406465641329364 2810 3312542 SGTC_3165 9101544 49.47 µM -0.238631736612644 0.402103864179331 no 2048 0.405695576849944 2934 5002184 SGTC_2877 9040724 71.43 µM -0.24028663944989 0.40144468390514 no 2049 0.405054025912001 3036 6463895 SGTC_1480 1070-0044 41.2 µM -0.242740655509194 0.400467717785463 no 2050 0.404103155318714 2913 3124987 SGTC_281 1672-3440 14.9 µM -0.242741617030116 0.40046733511682 no 2051 0.404102782863737 2930 6833000 SGTC_2563 tomatine 8.54 µM -0.243018452822725 0.400357163249734 no 2052 0.40399555130119 2907 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties. SGTC_1872 amphotericin b 148 nM -0.244019665461851 0.39995877861416 no 2053 0.40360779469278 2968 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1 SGTC_1746 st038117 42 µM -0.245384299102069 0.399415955696778 no 2054 0.403079442475267 2937 2898218 SGTC_1293 1000-1278 195 µM -0.246264280072908 0.399066020569728 no 2055 0.402738829477461 2985 678847 SGTC_178 4092-0806 87.505 µM -0.246279972771785 0.399059780912523 no 2056 0.402732755995645 2905 2169044 SGTC_979 1426-2828 121 µM -0.24823253184137 0.398283615291019 no 2057 0.401977248558955 2985 747872 SGTC_3251 9135047 49.47 µM -0.249206918040535 0.397896435367413 no 2058 0.401600364195436 2940 17682963 SGTC_1263 0774-1208 64.8 µM -0.24992846783345 0.397609786720021 no 2059 0.4013213337725 2990 906585 SGTC_2393 9031399 185.94 µM -0.25000754705566 0.397578374433425 no 2060 0.40129075611403 3013 1526623 YDL150W RPC53 SGTC_1669 st015249 58.4 µM -0.250381061917358 0.397430013771454 no 2061 0.401146336844871 2925 722793 SGTC_525 k781-2675 26.7 µM -0.25209283647487 0.396750284475435 no 2062 0.400484653431228 2847 3651118 YDL195W SEC31 SGTC_2974 9094440 9.66 µM -0.25230537596405 0.396665908923243 no 2063 0.400402516555408 3042 25236134 SGTC_1743 st037606 46.3785 µM -0.252336284919755 0.396653638852448 no 2064 0.400390572012227 2861 590142 YLR208W | YDL195W SEC13 | SEC31 SGTC_2858 9025781 8.96 µM -0.25366540684041 0.396126108156151 no 2065 0.399877030700686 2954 4894980 YPL153C RAD53 SGTC_119 0121-0043 24.815 µM -0.254026333493241 0.395982888558176 no 2066 0.399737607020131 2845 1092378 SGTC_2772 vinpocetine 57.06 µM -0.254610233861317 0.395751220316952 no 2067 0.399512077079518 3051 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor. SGTC_2800 7887935 81.82 µM -0.255568425644176 0.395371128090102 no 2068 0.399142050774867 3050 2961002 SGTC_2234 tolnaftate 200 µM -0.25849374526936 0.394211339430382 no 2069 0.39801293774789 2899 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7 SGTC_486 niguldipine 82 µM -0.258596691041953 0.394170541985342 no 2070 0.39797321829673 2842 1236 A calcium channel blocker. SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM -0.258870204397507 0.394062154190409 no 2071 0.397867694085377 2850 4620898 SGTC_1123 mangostin 811.285 nM -0.258948842332359 0.394030993090064 no 2072 0.397837356159449 2935 5281650 An antioxidant. SGTC_2092 5303694 80.6725 µM -0.259966949689963 0.3936276187649 no 2073 0.397444633807933 2872 1963699 SGTC_1965 Pectolinarigenin 58.4 µM -0.261016596820278 0.393211867858751 no 2074 0.397039854191381 2869 5320438 An anti-inflammatory. SGTC_966 1300-0360 30.2 µM -0.261131927038984 0.393166194548269 no 2075 0.396995385691897 2868 70588 SGTC_2212 7123476 200 µM -0.261671727714759 0.392952441131479 no 2076 0.396787269622442 2891 1085715 SGTC_1972 st070201 17.4 µM -0.26251941502251 0.392616834131796 no 2077 0.396460509535817 3004 2829099 SGTC_865 0488-0499 301 µM -0.262828993217875 0.392494289238092 no 2078 0.396341193790036 2955 9634651 SGTC_3011 9081274 71.4286 µM -0.26692478253597 0.390874000401093 no 2079 0.394763537501009 2900 6625322 SGTC_1939 st074455 53.6 µM -0.267127750859919 0.390793755390608 no 2080 0.394685400799289 3106 1644229 SGTC_2891 9063876 19.48 µM -0.267604728026978 0.390605197291033 no 2081 0.394501795612745 2989 6472478 SGTC_1623 st003709 20.3 µM -0.268091590580389 0.390412757839179 no 2082 0.394314409363341 2870 16192618 SGTC_1146 3579-1023 7 µM -0.268678314528864 0.390180882401796 no 2083 0.394088620428527 2989 X1146 SGTC_2002 4023503 131 µM -0.270894442505988 0.389305413652261 no 2084 0.393236109754742 2986 4736863 YCR052W RSC6 SGTC_2423 st077119 87.2 µM -0.271569655299693 0.389038786090688 no 2085 0.392976467191569 2845 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae). SGTC_1227 3909-8010 46.6 µM -0.272293545351668 0.38875299492017 no 2086 0.392698159427069 2896 15982272 SGTC_1685 st024049 53.0905 µM -0.272983339371558 0.388480720840719 no 2087 0.392433011305422 2978 1941139 SGTC_260 nsc-65238 3.989 µM -0.27459050862203 0.387846555033328 no 2088 0.391815429580177 3012 3246252 SGTC_2934 9036370 36.88 µM -0.275384445043699 0.38753338940697 no 2089 0.391510446661443 2991 6462800 SGTC_3288 9119690 36.221 µM -0.27548325355383 0.387494419828142 no 2090 0.391472494999353 2937 17595618 YKL019W RAM2 SGTC_1037 k284-1091 78.7 µM -0.275683901535462 0.387415288762915 no 2091 0.391395430683144 2862 3334711 SGTC_1260 0700-1617 7.75 µM -0.276325492475707 0.38716229108577 no 2092 0.391149038849002 3009 2853078 SGTC_669 0108-0021 26.2 µM -0.277188036838297 0.386822240688933 no 2093 0.390817862547257 3050 17201 SGTC_3133 9127736 49.47 µM -0.277994722571958 0.386504290658934 no 2094 0.390508204962499 3018 27243420 SGTC_3015 9080845 49.47 µM -0.278244542408537 0.386405841205008 no 2095 0.390412322201669 3030 5296973 SGTC_1805 st050013 60.3 µM -0.280865333352166 0.385373477006869 no 2096 0.389406845377986 2953 4037144 SGTC_370 0180-0345 38.7 µM -0.282198137179776 0.384848778845428 no 2097 0.388895793308149 2828 3989527 SGTC_2990 9074105 71.4286 µM -0.285657394301068 0.383487924467754 no 2098 0.387570269933082 2968 6502001 SGTC_919 tnp00227 403.569 nM -0.286134844036395 0.383300210548084 no 2099 0.387387422510143 2929 1269246 A methoxyflavone. YNL221C POP1 SGTC_2720 fluspirilene 36.88 µM -0.286309223685455 0.383231658352401 no 2100 0.387320647109906 2997 3396 An atypical antipsychotic. SGTC_774 k060-0086 136 µM -0.289421657362402 0.382008714121186 no 2101 0.386129361827358 3076 5911235 SGTC_3078 9116413 49.47 µM -0.292707894347871 0.380718755498828 no 2102 0.384872717620849 2835 17177322 SGTC_1555 citronellol 128 µM -0.294463966966199 0.380029980097811 no 2103 0.384201696825695 3022 8842 A terpine precursor. SGTC_2290 7904846 200 µM -0.294897675755407 0.379859927195785 no 2104 0.384036023756675 2989 2962154 SGTC_57 miconazole 162.5 nM -0.294960411573286 0.379835331027914 no 2105 0.384012060961205 2884 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_2941 9056145 11.23 µM -0.296874158934562 0.379085262391278 no 2106 0.383281292712792 2925 2119517 SGTC_2904 7225135 42.03 µM -0.298591797293353 0.378412443516606 no 2107 0.382625762449277 3036 4446116 SGTC_1984 st072354 53.1 µM -0.300087891569478 0.377826706169548 no 2108 0.382055057479335 2903 5762938 SGTC_3110 9122132 49.47 µM -0.301093521420493 0.377433148745745 no 2109 0.381671590549853 3093 918317 SGTC_2688 kanamycin b 96.69 µM -0.301120522554624 0.377422583491922 no 2110 0.381661296072034 3082 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis. SGTC_304 1310-0298 97 µM -0.301209197721927 0.377387886496603 no 2111 0.381627488283114 2989 1550234 SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM -0.301643315839237 0.377218038185651 no 2112 0.381461991919527 3000 4213774 SGTC_1385 3091-4834 14.1 µM -0.302638488945134 0.376828767305795 no 2113 0.381082689599738 3044 4072814 SGTC_2922 7999257 32.47 µM -0.305438625096914 0.375734141761373 no 2114 0.380016053899325 2931 2988377 SGTC_2322 7413319 38.22 µM -0.308133164746104 0.374681739167722 no 2115 0.378990503161768 3071 1840400 SGTC_2151 5563267 85.4165 µM -0.308555112813912 0.374517023764109 no 2116 0.378829985231641 2970 5310824 SGTC_26 0302-0163 425.158 µM -0.308923291157426 0.374373317092859 no 2117 0.37868993950836 2948 3100915 SGTC_339 3091-4833 71.4 µM -0.308942761758092 0.374365717850683 no 2118 0.378682533827947 2957 3240077 SGTC_385 1494-0393 12.4 µM -0.309423856982102 0.374177965186316 no 2119 0.378499562489493 2991 3090647 SGTC_1457 k015-0032 57.3 µM -0.310186224547289 0.373880504043118 no 2120 0.378209672741414 2918 4302660 SGTC_1825 st052143 62.6 µM -0.310546110858717 0.373740109416329 no 2121 0.378072850022836 3124 674173 SGTC_1518 st038567 90.8 µM -0.310929657907646 0.37359050298033 no 2122 0.377927048722066 2984 77966 SGTC_1484 3473-2379 286 µM -0.31128595062062 0.373451544440844 no 2123 0.377791623442006 2993 671917 SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM -0.311820369959301 0.373243145180613 no 2124 0.377588521185382 2988 66535 A nucleotide analog. SGTC_489 paxilline 115 µM -0.311834685462618 0.37323756329436 no 2125 0.377583081145668 3024 105008 A toxic potassium channel blocker. SGTC_2652 actinonin 100 µM -0.312209945080962 0.373091251944177 no 2126 0.377440487264086 2942 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase. SGTC_1576 erythromycin ethylsuccinate 23.2 µM -0.312667345392433 0.372912939206617 no 2127 0.377266703556182 2931 3256 An antibiotic and ribosome inhibitor. SGTC_3292 9120825 59.784 µM -0.313101338442286 0.372743776714796 no 2128 0.377101836129907 3116 24824900 SGTC_991 3996-0057 64.7 µM -0.313938125448209 0.372417681859371 no 2129 0.376784016603637 3043 715343 SGTC_1550 gossypolone 36.6 µM -0.314477817149666 0.372207413168108 no 2130 0.376579080921439 2958 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_1315 1237-0019 3.69 µM -0.314525442090873 0.372188859895398 no 2131 0.376560998099415 3079 825140 SGTC_1395 3486-0190 4.35 µM -0.314992022442256 0.372007109647256 no 2132 0.376383855478259 3124 6748079 SGTC_150 3970-0969 77.2 µM -0.315005629726998 0.372001809535934 no 2133 0.376378689705899 3065 6615640 SGTC_1631 benzylvanillin 81.9 µM -0.315675662320888 0.371740858219544 no 2134 0.376124350725129 3100 75506 SGTC_1910 st062352 60.4 µM -0.315756578246702 0.371709348637013 no 2135 0.376093639329005 2907 2245730 SGTC_1324 1418-0026 34.4 µM -0.316252961885925 0.371516070012859 no 2136 0.375905255590617 3073 1372513 SGTC_2755 lomerizine 42.69 µM -0.316690410461265 0.371345765986383 no 2137 0.37573926295023 2997 3949 A calcium channel blocker. SGTC_475 α-linolenic acid 10 µM -0.316877492011497 0.371272940560564 no 2138 0.375668280685813 3189 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_122 0236-0016 402.397 µM -0.319414406553649 0.370285849227127 no 2139 0.374706143853698 3015 6808838 SGTC_40 0327-0103 19.753 µM -0.320502695985168 0.369862666537936 no 2140 0.374293643485289 2994 409036 SGTC_1927 st060202 13.8 µM -0.320655732330456 0.369803170789044 no 2141 0.374235648798821 2972 688887 SGTC_505 gw-5074 63.9 µM -0.321133362326755 0.369617503219074 no 2142 0.374054664339144 3068 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases. SGTC_2224 6650123 117.647 µM -0.321315931410977 0.369546541754762 no 2143 0.373985492248024 2980 2908370 SGTC_2889 9059656 51.95 µM -0.323178927952639 0.36882268142892 no 2144 0.373279869214176 3059 3949838 SGTC_3124 9127567 49.47 µM -0.323537821522063 0.368683288027374 no 2145 0.373143984474603 3174 17592030 SGTC_1152 3909-8331 15.9 µM -0.324410930458966 0.36834424677937 no 2146 0.372813472770227 3009 16001939 SGTC_403 arphamenine a 50 µM -0.32470969509405 0.368228255529283 no 2147 0.372700398161516 2973 5487158 An arginine aminopeptidase inhibitor. SGTC_259 usnic acid 108.925 µM -0.325115821319881 0.368070601882826 no 2148 0.372546707587306 3183 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_1198 1612-1005 86.7 µM -0.325568891397763 0.367894751377816 no 2149 0.372375275971478 3168 6998509 SGTC_696 1560-0013 611 µM -0.325606476245095 0.367880164779587 no 2150 0.37236105583859 3177 1650269 SGTC_2906 7926292 26.41 µM -0.32761899660485 0.367099388703342 no 2151 0.371599878395117 3102 2966319 SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM -0.328884616164848 0.366608660896328 no 2152 0.371121451301398 2959 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1 SGTC_1405 3909-7894 12 µM -0.329435059854846 0.36639530135855 no 2153 0.370913435713615 3070 7104060 SGTC_1869 3',7'-dimethoxyflavone 40.3 µM -0.33327023475214 0.364909884212378 no 2154 0.369465152778404 3016 688664 SGTC_1696 st025591 34.7925 µM -0.334003010135737 0.364626299772027 no 2155 0.369188643612671 2997 2787147 SGTC_566 0958-0068 16.5 µM -0.334346953394042 0.364493219088909 no 2156 0.369058881652007 3161 6815365 SGTC_997 3996-0078 137 µM -0.334425124126446 0.364462975055808 no 2157 0.369029391694949 3055 735687 SGTC_2854 9024559 71.43 µM -0.334621453930488 0.364387019336409 no 2158 0.368955329555085 3074 3163529 SGTC_1770 st043884 66.3 µM -0.336725375137515 0.363573392946627 no 2159 0.368161966369203 2966 670149 SGTC_2498 4'-Methoxychalcone 54.63 µM -0.337293150044816 0.363353928794217 no 2160 0.367947961475279 3000 641818 YHR062C RPP1 SGTC_1992 st073643 23.3 µM -0.337310742357443 0.363347129487944 no 2161 0.367941331260561 2967 3161292 SGTC_3173 9105693 49.47 µM -0.338080231266767 0.363049769540451 no 2162 0.367651363755737 3159 17096658 SGTC_2900 5328528 85.29 µM -0.340926244013293 0.361950679796465 no 2163 0.366579553633234 3000 795359 SGTC_1519 esterone 74 µM -0.34110899434257 0.361880142984317 no 2164 0.366510765182908 2984 698 A steroid. SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM -0.341646586375559 0.361672673832303 no 2165 0.366308436801541 3190 5393153 SGTC_1199 1638-0010 4.46 µM -0.342002543041272 0.36153532432157 no 2166 0.366174489233041 2998 3111136 SGTC_1717 st033143 58.0435 µM -0.342188884762896 0.361463429580426 no 2167 0.366104374781567 3177 674616 SGTC_3254 9136651 49.47 µM -0.342777225057776 0.361236467046852 no 2168 0.365883030428859 3047 16454030 SGTC_760 0568-0725 82.9 µM -0.343650290071036 0.360899757007435 no 2169 0.365554649723873 3138 3916171 SGTC_2556 citropten 84.59 µM -0.343730733930927 0.36086873809848 no 2170 0.365524397810605 3037 2775 A potential DNA crosslinker. SGTC_1591 genipin 88.4 µM -0.344610431576622 0.360529589111513 no 2171 0.365193631205098 3132 442424 A DNA cross-linking agent. SGTC_1729 st035615 45.989 µM -0.344790507942186 0.360460177959669 no 2172 0.36512593478682 3113 17385451 SGTC_1078 idebenone 36.1 µM -0.345048484554343 0.360360747860236 no 2173 0.3650289605188 3085 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen. SGTC_3354 9151612 71.43 µM -0.345060144832986 0.360356253944586 no 2174 0.365024577585056 3135 27261949 SGTC_2154 5570129 200 µM -0.345186272752618 0.36030764499867 no 2175 0.36497716901199 3055 673366 SGTC_2078 5212016 200 µM -0.346129660248329 0.359944140753654 no 2176 0.364622636931998 3065 1899708 SGTC_342 k048-0088 23.3 µM -0.346906655987521 0.359644845335555 no 2177 0.3643307230324 2991 6820570 SGTC_2722 naftopidil 47.16 µM -0.348235723078695 0.359133094002962 no 2178 0.363831580806953 3137 4418 An a1-adrenergic receptor antagonist or alpha blocker.  SGTC_834 0312-0008 75.7 µM -0.348651569250953 0.358973026146496 no 2179 0.363675453711992 3016 6385573 YIL048W NEO1 SGTC_2520 obtusaquinone 4.71 µM -0.349079527943885 0.358808321778936 no 2180 0.363514802672886 3182 5967872 SGTC_767 0929-0023 86 µM -0.34975534766811 0.358548278974326 no 2181 0.363261156179956 3067 1204563 SGTC_1713 st033146 12.748 µM -0.351560500221952 0.357854011764467 no 2182 0.362583946298043 3180 674619 SGTC_2442 5158906 48.48 µM -0.35188076250274 0.357730886927017 no 2183 0.362463843497249 3154 1893835 SGTC_3122 9126309 49.47 µM -0.353222588864989 0.357215182827494 no 2184 0.361960787253247 3105 17591206 SGTC_2166 5933061 31.504 µM -0.353650821000273 0.357050655212689 no 2185 0.361800291396332 3475 2877375 SGTC_2239 6685329 187.64 µM -0.355913205735783 0.356181884411999 no 2186 0.360952782894797 3162 805680 SGTC_3123 9126162 49.47 µM -0.356801375643062 0.355841024929181 no 2187 0.360620253174484 3007 25239884 SGTC_2088 5278280 127.392 µM -0.35758729458979 0.355539503117197 no 2188 0.360326093946144 3130 791502 SGTC_372 0155-0182 15.9 µM -0.359336899288832 0.354868583159283 no 2189 0.359671536748227 3001 771486 SGTC_233 rapamycin 362 pM -0.36055414559109 0.354402071595803 no 2190 0.359216386545313 3079 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C SGTC_1116 jasmonic acid  1.58368 µM -0.361799067496523 0.35392517916767 no 2191 0.358751094519739 3175 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid. SGTC_1643 st009866 20.2 µM -0.361799995374841 0.353924823810522 no 2192 0.358750747801445 3130 3156273 YOR207C RET1 SGTC_2358 9037157 4 µM -0.361855813999594 0.353903446729353 no 2193 0.358729890390189 3130 2388925 SGTC_1356 1502-0781 85.8 µM -0.362841075830728 0.353526192945941 no 2194 0.358361802898837 3038 567702 SGTC_970 1315-0089 19.5 µM -0.362934958093681 0.353490253210677 no 2195 0.358326735949046 3095 6811083 YLR033W RSC58 SGTC_2489 cantharidin 73.42 µM -0.363755385165405 0.353176235315336 no 2196 0.358020340492444 3024 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_3092 9117248 49.47 µM -0.364396687266398 0.352930846962482 no 2197 0.357780904431054 3096 17141857 SGTC_720 r052-1644 49.9 µM -0.36625278934517 0.352220971545652 no 2198 0.357088227174556 3152 1422863 YOR257W CDC31 SGTC_1495 4469-0029 237 µM -0.366842575538771 0.351995512515498 no 2199 0.356868223787929 3064 793680 SGTC_2222 6885208 172.143 µM -0.367027715819055 0.351924749206475 no 2200 0.356799172151792 3083 609514 SGTC_3233 9132340 49.47 µM -0.370094130308855 0.350753468516735 no 2201 0.355656177721814 3052 17682950 SGTC_111 0083-0039 52.457 µM -0.373160499486754 0.349583621913443 no 2202 0.354514496557069 3008 759313 SGTC_886 0866-0150 153 µM -0.373525364638476 0.349444517461145 no 2203 0.354378735442934 3227 271463 SGTC_1283 0922-0125 16.4 µM -0.373605273690621 0.349414054917824 no 2204 0.354349004894544 3148 3360884 SGTC_2487 5918373 44.05 µM -0.374131020249114 0.349213656541724 no 2205 0.354153420488663 3209 2876279 SGTC_2184 6075246 200 µM -0.375134876133964 0.34883113442638 no 2206 0.353780080218319 3118 2267320 SGTC_2 0422-0095 29 µM -0.377164757595957 0.348058112023628 no 2207 0.353025584461574 3118 6790840 SGTC_2641 levomentholum 100 µM -0.37727002069231 0.348018042759666 no 2208 0.35298647447354 3124 16666 SGTC_625 k213-0058 121 µM -0.377278468154572 0.348014827237179 no 2209 0.352983335927616 3132 3655420 SGTC_2261 9010538 184.68 µM -0.377827840188505 0.347805732509669 no 2210 0.352779245303035 3156 6457250 SGTC_1830 st055982 50.3 µM -0.37793278579503 0.347765794761892 no 2211 0.352740263034735 3180 455313 An antimicrobial agent. SGTC_1632 st005650 90 µM -0.378156973189797 0.347680484418358 no 2212 0.352656993330743 3162 2759605 SGTC_3328 9140624 29.0385 µM -0.378889702152155 0.347401711855545 no 2213 0.352384885790229 3209 4904392 SGTC_1235 benzylparaben 21.5 µM -0.379050553039889 0.347340525896781 no 2214 0.352325162022549 3138 7180 SGTC_2108 5365811 200 µM -0.379628702905133 0.347120636722352 no 2215 0.352110525652173 3178 780283 SGTC_1611 st001856 99.4 µM -0.379956003563861 0.346996176457504 no 2216 0.351989037160287 3109 647478 SGTC_2173 5763948 167 µM -0.380921701582909 0.346629053654823 no 2217 0.351630674407635 3098 2867177 SGTC_1753 st043925 64 µM -0.381731949645347 0.346321138265853 no 2218 0.351330099553926 3175 670181 SGTC_3158 9100007 49.47 µM -0.382876389266445 0.345886394409964 no 2219 0.350905709248484 3067 19297233 SGTC_830 4076-0286 57.8 µM -0.383270546334324 0.345736711034624 no 2220 0.350759587772989 3084 6866659 SGTC_585 0kpi-0023 191 µM -0.385016268143124 0.345074053456525 no 2221 0.350112681336328 3198 64601 SGTC_983 1491-0821 12.2 µM -0.385142912517922 0.345025999036234 no 2222 0.350065768033346 3183 46495113 SGTC_1058 3448-5425 97.3 µM -0.385182660023371 0.34501091760777 no 2223 0.35005104470256 3114 7279705 SGTC_2562 3',7'-dimethoxyflavone 64.92 µM -0.385825353675215 0.344767094020431 no 2224 0.349813008456249 3211 688664 SGTC_925 2064-1272 59.6 µM -0.386341725101493 0.344571240953899 no 2225 0.349621801280009 3098 6815817 SGTC_1348 1493-0373 93.8 µM -0.386494197511124 0.344513418086358 no 2226 0.349565349563101 3131 3010129 SGTC_2076 5212012 200 µM -0.386698111621447 0.344436092406558 no 2227 0.349489857158543 3099 604802 SGTC_2545 solidagenone 89.61 µM -0.387268316475416 0.344219901189524 no 2228 0.34927878941519 2985 6708572 An anti ulcer agent SGTC_856 0433-0016 11.3 µM -0.387897871080396 0.343981266839329 no 2229 0.349045806827785 3172 3911780 SGTC_162 k030-0015 37.8 µM -0.387987229451234 0.343947400343867 no 2230 0.349012742113552 3155 1809920 YMR134W ERG29 SGTC_2050 5263056 171 µM -0.388138868279364 0.343889932647993 no 2231 0.348956634777933 3224 763468 YGL055W OLE1 SGTC_2874 9043904 71.43 µM -0.389210353660313 0.343483966693077 no 2232 0.348560272506121 3138 4463428 SGTC_667 1498-1044 59 µM -0.389273790266309 0.343459937393266 no 2233 0.348536811309523 3123 6739982 SGTC_688 0527-0193 473 µM -0.389365746108052 0.34342510634897 no 2234 0.348502803676288 3083 4007154 SGTC_2099 5377090 177.372 µM -0.390566026391766 0.342970586091341 no 2235 0.348059020945345 3178 2243829 SGTC_3055 9094636 49.47 µM -0.390931605607022 0.342832194223586 no 2236 0.347923895694766 3277 25236176 SGTC_204 PMA1.184 62.41 µM -0.39349135700318 0.341863778974187 no 2237 0.346978303176346 3117 2252213 YGL008C PMA1 SGTC_1035 k081-0041 55.2 µM -0.394647982857231 0.341426540317351 no 2238 0.346551348327897 3242 731709 SGTC_1934 st074720 32.6 µM -0.394833517687182 0.341356422469974 no 2239 0.346482878446388 3059 17250992 SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM -0.395160127711159 0.341233002392665 no 2240 0.346362358280578 3200 7104 SGTC_2181 6316240 54.2555 µM -0.395397260455269 0.341143404816285 no 2241 0.346274865268528 3183 12779990 SGTC_570 0987-0065 62.6 µM -0.395457632847165 0.341120595309821 no 2242 0.34625259144967 3079 3104428 SGTC_1722 st034304 3.6505 µM -0.395900423292079 0.340953320838197 no 2243 0.346089244390426 3104 4036148 YLR033W RSC58 SGTC_1773 st048542 73.5835 µM -0.396816779054351 0.340607245284215 no 2244 0.345751288277725 3075 3237138 SGTC_1527 coumarin 137 µM -0.397003030106358 0.340536921163582 no 2245 0.345682613071492 3264 323 A hepatotoxic, DNA x-linker. SGTC_2869 9037858 32.47 µM -0.397940785111576 0.340182930669796 no 2246 0.345336917615077 3061 27187042 SGTC_2732 terfenadine 20 µM -0.399585817673379 0.339562292278294 no 2247 0.344730802004676 3128 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.  SGTC_51 1013-0126 23.419 µM -0.400110796713159 0.339364319467713 no 2248 0.344537456172816 3367 1627850 SGTC_2816 7982706 58.44 µM -0.400392496667191 0.339258106961288 no 2249 0.344433724936769 3196 2981853 SGTC_1546 5-methoxyflavanone 78.7 µM -0.400657435352306 0.339158225798059 no 2250 0.344336176429725 3180 147795 SGTC_2903 5923464 63.88 µM -0.402099481974421 0.338614776481512 no 2251 0.34380540699921 3205 2876576 SGTC_2063 5246145 200 µM -0.403091738866905 0.338241029786255 no 2252 0.343440368853246 3224 711240 SGTC_642 0335-0876 158 µM -0.404424632078025 0.337739228725829 no 2253 0.342950244924982 3146 6812350 SGTC_1318 1280-3875 124 µM -0.404858161119895 0.337576077942194 no 2254 0.342790886976824 3169 373245 SGTC_757 1066-0008 322 µM -0.405053537008264 0.337502561749757 no 2255 0.342719079243168 3236 6842497 SGTC_2144 5628481 200 µM -0.406127534574537 0.33709854791531 no 2256 0.342324447673623 3136 2818399 SGTC_3154 9100113 49.47 µM -0.406520111129357 0.336950916256108 no 2257 0.342180241577525 3119 25237525 SGTC_708 3448-5400 146 µM -0.406758982989481 0.336861098806113 no 2258 0.342092507458847 3212 3462195 SGTC_1863 st057641 20.1 µM -0.409260649063822 0.335921014983332 no 2259 0.341174195219239 3197 3921635 SGTC_262 fenpropimorph 62.5 µM -0.411613000181455 0.335037976531863 no 2260 0.340311550725236 3180 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_1635 st007035 42.4 µM -0.413313162479646 0.334400327137892 no 2261 0.339688593744181 3213 3716403 SGTC_2777 climbazole 1.536 µM -0.414802740390781 0.333842050184819 no 2262 0.339143156653593 3202 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2 SGTC_2367 9070478 135.38 µM -0.414883173271463 0.333811915300468 no 2263 0.339113714213223 3113 572802 SGTC_2372 9071633 200 µM -0.418504868163124 0.332456128791168 no 2264 0.337789013999435 3270 21321366 SGTC_393 acivicin 6.25 µM -0.420754903098246 0.331614926270482 no 2265 0.336967032659214 3093 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1 SGTC_1185 1319-0113 81.3 µM -0.423407060058441 0.330624475215473 no 2266 0.335999147364004 3240 4672763 SGTC_1799 st045822 46.1415 µM -0.423716409410497 0.330509025379461 no 2267 0.335886323213158 3277 3674992 SGTC_179 1273-0063 6.77 µM -0.423967789382917 0.330415221715692 no 2268 0.335794652217723 3120 3108139 SGTC_345 1362-0200 395 µM -0.426819424373506 0.329351867365028 no 2269 0.334755428676231 3163 1419823 SGTC_2635 hydroquinidine 100 µM -0.427520213912731 0.329090758655992 no 2270 0.334500232635881 3122 442912 An experimental heart treatment. SGTC_1779 st039427 55 µM -0.428145063114575 0.328858015016696 no 2271 0.334272755117366 3349 1124498 SGTC_522 1273-0010 11.6 µM -0.428153679513255 0.328854806046733 no 2272 0.334269618726493 3352 5705015 SGTC_2065 5221596 34.26 µM -0.43111193055576 0.327753823860432 no 2273 0.333193493081272 3268 788581 SGTC_118 0083-0097 135.343 µM -0.431842780917561 0.327482050867761 no 2274 0.332927841971675 3225 5207356 SGTC_542 3381-0244 89.3 µM -0.432541798484152 0.327222200679807 no 2275 0.33267383994766 3308 1112843 SGTC_350 k064-0020 19.8 µM -0.432609235049785 0.327197136487767 no 2276 0.332649339581435 3324 2790705 SGTC_28 pentachloropyridine N-oxide 1.606 µM -0.432620714134923 0.327192870126362 no 2277 0.332645169188316 3266 140250 A respiratory chain inhibitor. SGTC_347 4534-1311 26.2 µM -0.433572906699202 0.32683905319533 no 2278 0.33229930634141 3190 2862016 SGTC_3115 9123671 49.47 µM -0.433699947706883 0.326791858896163 no 2279 0.3322531722992 3292 3286988 SGTC_1236 0330-0013 258 µM -0.436373626158572 0.325799261365201 no 2280 0.331282835503961 3173 4617066 SGTC_1137 ixabepilone 100 µM -0.437601815332652 0.325343711731851 no 2281 0.330837477514568 3210 154225 A novel microtubule stabilizer. SGTC_1291 0993-0025 5.79 µM -0.439536032494277 0.324626817164494 no 2282 0.33013658962402 3293 4353356 SGTC_1257 0669-0121 16 µM -0.440272112221109 0.324354168377535 no 2283 0.329870018233526 3230 4307855 SGTC_3008 9078912 71.4286 µM -0.441375873238084 0.323945504466819 no 2284 0.329470452910862 3192 16648731 SGTC_2471 5466956 24.79 µM -0.441718440717694 0.323818713083726 no 2285 0.329346481847797 3155 724419 SGTC_706 4262-0057 46.9 µM -0.442240537105052 0.323625513622739 no 2286 0.329157577508754 3180 883298 SGTC_580 1123-0028 41 µM -0.442665301602634 0.323468366457391 no 2287 0.329003921858747 3220 1677248 YPR107C YTH1 SGTC_2838 9002687 71.43 µM -0.442703054373918 0.323454400850336 no 2288 0.328990266449697 3128 6457060 SGTC_800 3448-7362 155 µM -0.443472024016701 0.323169995672213 no 2289 0.328712175099985 3282 15991913 SGTC_2821 7996764 71.43 µM -0.444190043676322 0.322904527740406 no 2290 0.328452594979087 3400 2987135 SGTC_3017 9080681 49.47 µM -0.445474728008468 0.322429776346148 no 2291 0.327988359557752 3254 16451914 SGTC_471 1-acyl-paf 4 µM -0.448316177758826 0.321380755659705 no 2292 0.326962513368942 3181 16759367 SGTC_3031 9088762 49.47 µM -0.448455706177804 0.32132928044942 no 2293 0.326912173127271 3141 205253 SGTC_2966 9084041 48.03 µM -0.448918102727924 0.321158716370428 no 2294 0.326745368313828 3063 17741380 SGTC_995 3931-2021 34.6 µM -0.449070484078084 0.32110251576857 no 2295 0.326690405887739 3257 730143 SGTC_2731 amoxapine 43.43 µM -0.449502111719827 0.320943347053929 no 2296 0.326534742540004 3265 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine. SGTC_1783 st039459 87.517 µM -0.450423638150786 0.320603631460149 no 2297 0.326202501874168 3366 729761 SGTC_1971 st069429 63.5 µM -0.45068405255379 0.320507658348987 no 2298 0.326108638871513 3285 1246522 YGL099W LSG1 SGTC_1112 tnp00069 1.16933 µM -0.452072547166676 0.319996145314113 no 2299 0.32560836002051 3275 145826 SGTC_2228 7354201 200 µM -0.453059568094643 0.319632740662599 no 2300 0.325252924214516 3235 753451 SGTC_2120 5538279 151.968 µM -0.453387706777316 0.319511963794771 no 2301 0.325134793476254 3233 2058197 SGTC_578 3460-0051 92 µM -0.453632112516631 0.319422018659303 no 2302 0.325046818223515 3345 2876744 SGTC_2512 diallyl trisulfide 49.23 µM -0.453792791424306 0.319362892095537 no 2303 0.324988986239301 3286 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent SGTC_2235 salicylic acid 500 µM -0.454427458057827 0.319129392620476 no 2304 0.32476059655191 3271 338 A COX inhibitor and kinase inhibitor. SGTC_112 phenothiazine 287.218 µM -0.454875265982855 0.318964683279731 no 2305 0.324599489037838 3339 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.  SGTC_3166 9102297 49.47 µM -0.455841882851124 0.318609271414124 no 2306 0.324251841921882 3253 25237072 SGTC_1701 st028638 40.4 µM -0.456310027257052 0.318437201026765 no 2307 0.324083527190279 3316 3490878 SGTC_3062 9077494 49.47 µM -0.456951236087094 0.318201582916189 no 2308 0.323853047930734 3297 16459633 SGTC_86 0417-1630 471.922 µM -0.459451426745844 0.317283567885299 no 2309 0.322955012697811 3295 3634867 SGTC_2687 chenodiol 100 µM -0.459938821529024 0.317104737864021 no 2310 0.322780066918539 3305 5702181 A cholesterol synthesis inhibitor. SGTC_712 r015-0009 80.6 µM -0.460016559488301 0.317076218976958 no 2311 0.322752167233407 3298 6813872 YLR060W FRS1 SGTC_136 0097-0015 404.482 µM -0.460144166740835 0.317029407435482 no 2312 0.322706371922528 3309 4861337 SGTC_1769 st044406 64.4 µM -0.464421252660419 0.315462095782381 no 2313 0.321172983206369 3190 670903 SGTC_1084 voriconazole 435 nM -0.464655137323224 0.315376485521235 no 2314 0.321089220179982 3324 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_2627 acetyl isogambogic acid 100 µM -0.464748314789854 0.315342381952713 no 2315 0.321055852307427 3297 6857789 A caspase activator and apoptosis inducer. SGTC_2727 riluzole 51.77 µM -0.464804566376627 0.315321794261785 no 2316 0.321035708696817 3281 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.  SGTC_386 1509-0011 3.07 µM -0.466029597808679 0.314873583562027 no 2317 0.32059715745189 3243 3107280 SGTC_3121 9125696 49.47 µM -0.468465610441261 0.313983113078396 no 2318 0.319725829066994 3255 1235365 SGTC_2361 9034121 116 µM -0.470384593121588 0.3132824015197 no 2319 0.319040134799154 3234 6496917 SGTC_365 0121-0052 13.6 µM -0.471794603733585 0.312767968883583 no 2320 0.318536701511056 3333 3101739 SGTC_2912 7964298 10.93 µM -0.47228761223182 0.312588184078468 no 2321 0.318360755627703 3315 2975850 SGTC_790 1575-0012 79.1 µM -0.472379992849079 0.312554500710947 no 2322 0.318327791199636 3348 378741 YLR208W SEC13 SGTC_2233 sulbentine 40.3845 µM -0.472669438356958 0.312448974648877 no 2323 0.318224516883493 3272 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58 SGTC_3161 9100388 49.47 µM -0.474829732518951 0.311661860640187 no 2324 0.317454169424396 3261 25236368 SGTC_2079 5212404 121 µM -0.476434984884942 0.311077535398361 no 2325 0.316882257744331 3375 758462 SGTC_1008 4106-0037 6 µM -0.478737032470976 0.310240401662216 no 2326 0.316062858568592 3258 2905394 SGTC_2552 juarezic acid 87.02 µM -0.479436214293708 0.309986340256876 no 2327 0.315814167787554 3279 1549512 SGTC_1761 st044296 37 µM -0.479679077177087 0.309898112491366 no 2328 0.315727803805436 3208 1826700 SGTC_3350 9150499 3.57 µM -0.481910994276662 0.309087809824402 no 2329 0.314934587815613 3254 4910996 YPR165W RHO1 SGTC_906 1165-0455 526 µM -0.482686742266489 0.308806389833292 no 2330 0.314659089074134 3285 3252859 SGTC_561 1550-0330 72.9 µM -0.483627993808479 0.308465080408664 no 2331 0.314324951991875 3245 6812934 SGTC_2977 9011197 71.43 µM -0.48388270866019 0.308372746093911 no 2332 0.314234556306718 3411 2704722 SGTC_1757 st041620 31.8375 µM -0.485759853089206 0.307692654018113 no 2333 0.313568720903521 3322 5289815 SGTC_3042 9091578 49.47 µM -0.486283856908353 0.3075029244804 no 2334 0.313382961592488 3343 25236497 SGTC_2301 7769476 200 µM -0.486483680882976 0.307430586446867 no 2335 0.313312136473033 3293 977820 SGTC_1134 3477-0009 42.5 µM -0.487493041189044 0.307065303661053 no 2336 0.312954486545703 3445 3973534 SGTC_519 k048-0011 62.8 µM -0.487930690391211 0.306906979921391 no 2337 0.312799467542629 3305 6836379 SGTC_1294 1000-1494 117 µM -0.488279680859116 0.306780755119372 no 2338 0.312675875923534 3294 712797 YDL207W GLE1 SGTC_469 w7 172 µM -0.48835481283633 0.306753583966601 no 2339 0.312649271410532 3338 45115570 A P450 inhibitor. SGTC_133 0724-0033 378.92 µM -0.489866182508258 0.306207229374232 no 2340 0.312114297253512 3182 280309 SGTC_878 0828-0289 13.7 µM -0.489890922558215 0.306198289516651 no 2341 0.312105543396935 3276 745350 YLR208W SEC13 SGTC_2197 6588183 93.1375 µM -0.49007109884836 0.306133185999824 no 2342 0.31204179420352 3268 884136 SGTC_2289 7946404 165.07 µM -0.492290388975195 0.305331787395015 no 2343 0.311257036736734 3258 1246120 YPR165W RHO1 SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM -0.493769307633578 0.30479825850728 no 2344 0.310734555723098 3350 279621 SGTC_771 0250-0039 27.3 µM -0.494391000481051 0.304574102811936 no 2345 0.310515034259511 3250 3005115 SGTC_553 k007-0256 45.7 µM -0.495064838204565 0.304331228771472 no 2346 0.310277176484505 3307 6287000 SGTC_1514 1189-1591 158 µM -0.495268792089239 0.304257733856827 no 2347 0.310205198500766 3422 767698 YMR146C TIF34 SGTC_2189 6047310 154.431 µM -0.495467884577464 0.304185998375142 no 2348 0.310134943179568 3266 711535 SGTC_34 0469-0683 81.75 µM -0.496014380761638 0.303989127791953 no 2349 0.309942132427734 3339 3690923 SGTC_579 4491-1009 110 µM -0.496303742694633 0.30388491063397 no 2350 0.309840063042975 3428 1271041 SGTC_2630 antimycin a 100 µM -0.497144598517511 0.303582156837017 no 2351 0.309543543181177 3266 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain. SGTC_2115 tiliquinol 12.7705 µM -0.499333019124926 0.3027948386357 no 2352 0.308772398707906 3309 71208 A bioactive hydroxyquinoline. SGTC_1408 3909-7976 48.8 µM -0.499610289385086 0.302695151664267 no 2353 0.308674755685789 3322 24152374 SGTC_1523 st012844 44.7 µM -0.500312810516613 0.302442640100138 no 2354 0.308427417603022 3388 4274103 SGTC_3220 9131269 49.47 µM -0.503323358109064 0.301361611546624 no 2355 0.307368473295026 3389 17722206 SGTC_1200 1643-0193 18.4 µM -0.505907830782251 0.300434968296639 no 2356 0.306460677387848 3405 5403974 SGTC_1027 k015-0025 8.67 µM -0.506011868137335 0.300397693448753 no 2357 0.306424159077069 3327 3598955 SGTC_740 k014-0057 261 µM -0.506772235875153 0.30012532984436 no 2358 0.306157319624709 3351 4012779 SGTC_2643 anethole 100 µM -0.506805946225563 0.300113257387998 no 2359 0.30614549187076 3355 637563 An anti-fungal, anti-helmenthic and channel blocker. SGTC_799 1310-0557 151 µM -0.507097107807129 0.300008994831877 no 2360 0.306043342116561 3407 5354492 SGTC_2634 4'-methoxyflavone 100 µM -0.507721631064958 0.299785413510511 no 2361 0.305824288200446 3326 77793 From seeds of Psoralea corylifolia (Fabaceae) SGTC_173 1273-0061 2.693 µM -0.509132508008832 0.29928059303967 no 2362 0.305329673488972 3356 2847414 YPL266W DIM1 SGTC_2446 5162541 200 µM -0.509567068339531 0.299125182393838 no 2363 0.305177400080722 3284 1549321 SGTC_1547 harmine 94.2 µM -0.510366060839258 0.298839536485697 no 2364 0.304897514730098 3380 5280953 A monoamine oxidase inhibitor YHR072W ERG7 SGTC_2963 9082507 9 µM -0.511270833317753 0.298516223159801 no 2365 0.304580712656374 3397 16459611 SGTC_1352 1496-0991 99 µM -0.511762929620388 0.298340443254848 no 2366 0.304408468818708 3312 3000039 SGTC_1645 Cervolide 78 µM -0.513106172119345 0.297860868570567 no 2367 0.303938527152646 3360 23173 A fragrance. SGTC_1652 st011932 78 µM -0.514456781804793 0.297379018339612 no 2368 0.303466334485147 3358 1551076 SGTC_1768 st044301 37.178 µM -0.516318207614612 0.296715510994887 no 2369 0.302816090754139 3317 3931349 SGTC_2682 pyrogallin 40.03 µM -0.518662109430041 0.295880990086948 no 2370 0.301998194475932 3348 822798 An ATP competetive kinase inhibitor. SGTC_332 4112-0506 40.9 µM -0.519348407005939 0.295636845424602 no 2371 0.301758901284808 3344 2790355 SGTC_2268 7933382 153.85 µM -0.519670132643401 0.29552242608966 no 2372 0.30164675370871 3400 935025 YOR257W CDC31 SGTC_668 1682-0499 62.6 µM -0.519974076587018 0.295414349392157 no 2373 0.301540821723186 3355 682214 SGTC_1762 st045503 25.4615 µM -0.521885059881824 0.294735256921774 no 2374 0.300875180546902 3373 4645554 SGTC_3349 9149703 23.001 µM -0.521886202282721 0.294734851170315 no 2375 0.300874782819625 3392 4910494 SGTC_76 0433-0009 400.328 µM -0.522255009032791 0.294603873951256 no 2376 0.300746395016137 3378 2841569 SGTC_125 0133-0007 11.75 µM -0.523118649845331 0.294297267564307 no 2377 0.300445843961197 3459 26541 SGTC_1957 st077035 62.4 µM -0.523350754516726 0.2942148918034 no 2378 0.300365093584416 3444 705593 SGTC_1437 4092-1038 11.6 µM -0.524307570706983 0.293875422782762 no 2379 0.300032316034787 3335 3977136 SGTC_528 3492-0019 172 µM -0.524620244341006 0.29376452852513 no 2380 0.29992360533619 3411 2869262 SGTC_2243 6634756 200 µM -0.524678047354182 0.29374402996558 no 2381 0.299903510276285 3484 885676 SGTC_940 3232-1287 54.8 µM -0.525020799696151 0.293622494033147 no 2382 0.299784365881885 3416 1585493 YIL048W NEO1 SGTC_2505 galangin 7.89 µM -0.526136236219959 0.2932271346603 no 2383 0.299396776630489 3307 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_623 k072-0108 16.9 µM -0.526594688135808 0.293064710890246 no 2384 0.299237540758589 3369 5382803 SGTC_905 2-aminofluorene 215 µM -0.526650178274629 0.293045054260937 no 2385 0.299218269761981 3431 1539 An established DNA mutagen. YPR165W RHO1 SGTC_1905 st060207 84.5 µM -0.527455443246257 0.292759868925765 no 2386 0.298938675218373 3315 1948547 SGTC_735 3076-0345 636 µM -0.52793330095145 0.292590696129407 no 2387 0.298772815263814 3463 2888990 SGTC_2917 7979103 53.79 µM -0.530697580662446 0.291612969012216 no 2388 0.297814181414458 3433 2980565 SGTC_680 0417-1641 114 µM -0.53085495286476 0.291557352242366 no 2389 0.297759648008984 3273 2835990 SGTC_2662 daunorubicin 22.37 µM -0.531744575392554 0.291243044588568 no 2390 0.297451457240285 3345 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_2728 chlorpromazine 9.18 µM -0.531985113240258 0.291158088654615 no 2391 0.297368153053716 3380 2726 A thorazine and dopamine antagonist. SGTC_795 0685-0265 78 µM -0.533380401673217 0.290665512977395 no 2392 0.296885140626036 3473 302754 SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM -0.533590515259863 0.290591370810993 no 2393 0.296812435901325 3375 6708739 YPR165W RHO1 SGTC_843 0310-0051 143 µM -0.533645441884727 0.290571990472606 no 2394 0.296793431215059 3369 2065037 SGTC_1105 epirubicin 18.1 µM -0.536605477014779 0.289528465814649 no 2395 0.295770080033427 3332 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_400 oxethazaine 37.5 µM -0.537886331577129 0.289077462157295 no 2396 0.295327762688983 3401 4621 A local anesthetic. SGTC_438 sphingosine 6.67 µM -0.539646089714526 0.288458370405625 no 2397 0.294720562512334 3264 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes. SGTC_441 propafenone 146 µM -0.542527767241929 0.287445933435135 no 2398 0.293727492101854 3362 4932 Slows the influx of sodium ions into the cardiac muscle. SGTC_167 3672-0051 66.205 µM -0.542773574394442 0.287359650389979 no 2399 0.293642854901931 3377 3237971 SGTC_3272 9137413 49.47 µM -0.542932403887215 0.287303904695916 no 2400 0.293588172166517 3392 17614870 SGTC_1089 terbinafine 2.25 µM -0.543039624461849 0.287266275501875 no 2401 0.293551260313537 3439 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_1456 k015-0012 13 µM -0.543088782807467 0.287249024099144 no 2402 0.293534337735087 3505 2989616 SGTC_2227 7312221 64.1025 µM -0.544019936156748 0.286922342084049 no 2403 0.293213877002769 3418 887188 YOR168W | YOR169C GLN4 | YOR169C SGTC_53 0973-0023 39.979 µM -0.545116863511743 0.286537726568981 no 2404 0.292836572599624 3481 674768 SGTC_510 ag-490 170 µM -0.545646782103441 0.286352008934143 no 2405 0.292654380032941 3505 5328779 SGTC_1033 k072-0102 21.3 µM -0.546067280382813 0.286204679902796 no 2406 0.292509845003003 3451 5965931 SGTC_715 0868-0130 184 µM -0.546467190102261 0.286064597847142 no 2407 0.292372417526242 3487 2876258 SGTC_2765 myclobutanil 7.74 µM -0.546503547270673 0.286051864121238 no 2408 0.29235992501046 3446 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11 SGTC_3002 9075603 71.4286 µM -0.54705539101328 0.285858619579766 no 2409 0.292170339058284 3447 20105405 SGTC_1292 0kpi-0043 232 µM -0.547929832441253 0.285552535012866 no 2410 0.291870041849851 3393 3333905 SGTC_3005 9076496 71.4286 µM -0.548674962965639 0.28529183687155 no 2411 0.291614265585618 3437 21368410 SGTC_2949 9072542 2.23 µM -0.548683328978257 0.285288910506078 no 2412 0.291611394430453 3423 16457352 SGTC_2025 5147754 141 µM -0.549006784176069 0.285175779385685 no 2413 0.291500397047065 3409 315777 YLR208W SEC13 SGTC_2768 sulfasalazine 50.2 µM -0.549377393939244 0.285046181856473 no 2414 0.291373242259354 3501 5384001 An antioxidant and salicylic acid derivative. SGTC_1436 4092-1007 8.32 µM -0.551599244967921 0.284269818146386 no 2415 0.29061147692152 3382 2881121 SGTC_1629 st005085 44.9 µM -0.552526237789238 0.283946205533095 no 2416 0.290293931576138 3347 24207091 SGTC_2152 5568786 200 µM -0.552848561176507 0.283833723961767 no 2417 0.290183556413451 3414 5399883 SGTC_1157 4092-0394 27.6 µM -0.552865329898076 0.28382787274507 no 2418 0.290177814736006 3544 3659885 SGTC_1574 spiramycin 23.7 µM -0.553145898240842 0.283729980815319 no 2419 0.290081754908415 3405 6419898 An antibiotic and protein synthesis inhibitor. SGTC_626 0214-0009 33 µM -0.556043386193016 0.282719977240244 no 2420 0.289090597823598 3470 3437874 SGTC_3028 9087778 49.47 µM -0.56145837658058 0.280837069407234 no 2421 0.28724254887898 3367 17217395 SGTC_2029 5175081 200 µM -0.562449020684869 0.280493258459385 no 2422 0.286905063968008 3450 1380876 SGTC_754 3474-0146 171 µM -0.562898882842229 0.280337197496861 no 2423 0.28675187048889 3314 24762078 SGTC_2706 st078239 82.5 µM -0.563184379164798 0.280238178238838 no 2424 0.286654669326154 3483 15434492 SGTC_2735 sertaconazole 140 nM -0.563526421521632 0.280119569320458 no 2425 0.286538236862975 3467 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C SGTC_1587 estradiol valerate 56.1 µM -0.564501410682693 0.27978160906271 no 2426 0.286206470184862 3494 13791 A steroid. SGTC_815 1582-0027 36.9 µM -0.565095672826264 0.279575717194243 no 2427 0.286004345794542 3463 3128206 SGTC_220 paclitaxel 373.376 µM -0.567671719905861 0.278684054932755 no 2428 0.28512894888314 3454 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_946 3434-1334 87.4 µM -0.568194799909199 0.278503167449994 no 2429 0.28495135102195 3440 4047976 SGTC_976 1348-1067 47.6 µM -0.568525818569341 0.278388726694737 no 2430 0.284838989730954 3468 5310671 YGL099W LSG1 SGTC_1073 triclabendazole 3.09 µM -0.568909414080539 0.278256137587347 no 2431 0.284708808151587 3472 50248 An antihelmetic and likely tubulin inhibitor. SGTC_2090 5301565 104.445 µM -0.570277088709697 0.277783654012752 no 2432 0.284244888949405 3441 2056344 SGTC_2931 9014674 55.67 µM -0.573785947679626 0.276573261228617 no 2433 0.283056329535078 3389 2996810 SGTC_996 3970-0799 1.8 µM -0.577034052735267 0.27545512555725 no 2434 0.281958226030537 3525 6615648 YGL040C HEM2 SGTC_5 0352-0601 109.883 µM -0.577538790286605 0.275281573299861 no 2435 0.281787771215466 3421 762456 SGTC_2440 5628896 157.78 µM -0.577973079682056 0.275132287487572 no 2436 0.281641147195496 3456 5522048 SGTC_884 0851-0618 334 µM -0.578284437794086 0.275025283516248 no 2437 0.28153604966629 3489 9642473 SGTC_1450 4112-4260 37.6 µM -0.578659081001305 0.274896557632145 no 2438 0.281409615619832 3506 1633175 SGTC_2733 amorolfine 100 µM -0.579060233120803 0.274758756319498 no 2439 0.281274265768618 3476 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_218 alverine citrate 93.75 µM -0.580232056273472 0.27435641398062 no 2440 0.280879069443359 3508 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_3201 9113999 49.47 µM -0.584188785442863 0.273000034432369 no 2441 0.279546652871108 3488 16649224 SGTC_3348 9149464 3.537 µM -0.584218443456721 0.27298988013578 no 2442 0.279536677223278 3496 1951442 SGTC_1904 st060225 78 µM -0.584562680784292 0.272872034026205 no 2443 0.279420903615828 3491 66595 SGTC_2677 mitomycin C 100 µM -0.584617279976171 0.272853344872834 no 2444 0.279402543001844 3484 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_371 0195-0006 7.36 µM -0.58678051251146 0.27211338761427 no 2445 0.278675563220361 3432 3928593 SGTC_2242 6630449 61.2675 µM -0.586981202655711 0.272044789966779 no 2446 0.278608165645032 3486 691249 YDR170C SEC7 SGTC_854 0422-0053 192 µM -0.588316199193117 0.271588695433162 no 2447 0.278160037200683 3513 3596728 SGTC_1418 3966-3099 2.4 µM -0.5903911415955 0.270880558957457 no 2448 0.277464224058995 3507 740335 SGTC_1363 1636-0063 10.4 µM -0.591690321532107 0.270437644321516 no 2449 0.277028989381437 3503 6072185 SGTC_1174 0739-0097 51.1 µM -0.592647258117866 0.270111638441748 no 2450 0.276708622568453 3474 728447 SGTC_2406 ethylparaben 405.7 µM -0.593447316156261 0.269839228380495 no 2451 0.276440915546692 3275 8434 A possible steroid mimic. SGTC_2770 toltrazuril 17.5 µM -0.594902348749463 0.269344160225437 no 2452 0.275954373597628 3521 68591 Kills coccidiodes. SGTC_2258 7960471 200 µM -0.595166396237525 0.269254368129278 no 2453 0.275866125028777 3459 2974708 SGTC_152 4469-0003 551.229 µM -0.595515653311623 0.269135622694492 no 2454 0.27574941946096 3523 697280 SGTC_2073 5212005 126 µM -0.596578850083965 0.268774303607791 no 2455 0.275394297690905 3415 691789 SGTC_432 NS 1619 61.3 µM -0.596955209514767 0.268646459223056 no 2456 0.275268642617704 3523 4552 A K+/calcium channel activator. SGTC_1676 st018489 23.4 µM -0.600082018471481 0.267585505955688 no 2457 0.274225787849988 3453 3696235 SGTC_2177 5811945 192 µM -0.600147016970505 0.267563473835567 no 2458 0.274204130239266 3536 5343475 SGTC_2132 5317594 122.667 µM -0.600557562145064 0.267424335132656 no 2459 0.27406735540927 3483 794577 SGTC_463 ikarugamyin 104 µM -0.600950842879788 0.267291081789505 no 2460 0.273936363920309 3525 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis. SGTC_2107 5363541 170.161 µM -0.601852270885884 0.266985781904966 no 2461 0.273636238724129 3505 244052 SGTC_387 norethindrone acetate 66.7 µM -0.602063847047492 0.266914149821816 no 2462 0.273565819256831 3473 541197 SGTC_890 0929-0006 47.2 µM -0.602814990632414 0.266659918046875 no 2463 0.273315886564669 3442 1378169 SGTC_2775 cyproheptadine 69.59 µM -0.603120454650224 0.266556565836383 no 2464 0.273214279972416 3563 2913 A selective serotonin reuptake inhibitor. SGTC_2792 7535235 81.82 µM -0.603443291542887 0.266447357623896 no 2465 0.273106914979952 3448 1281891 SGTC_2794 7785382 27.27 µM -0.604358080616735 0.266138028741272 no 2466 0.27280279966845 3523 2205081 SGTC_3209 9113616 49.47 µM -0.605157977375513 0.265867698904182 no 2467 0.272537017254631 3573 16649353 SGTC_1959 st077091 55.8 µM -0.606531123757367 0.265403960663389 no 2468 0.272081060658056 3522 821356 YKL052C ASK1 SGTC_3168 9103419 49.47 µM -0.607961209525172 0.264921429633714 no 2469 0.271606600732423 3492 16649256 SGTC_2159 5658611 73.75 µM -0.608751163533468 0.264655079342647 no 2470 0.271344694237097 3560 793844 SGTC_1180 1193-0155 285 µM -0.608938707655519 0.264591864747505 no 2471 0.271282533129561 3530 2921347 SGTC_3312 9133330 71.43 µM -0.610848245946757 0.263948663414005 no 2472 0.270650024980545 3566 17617324 SGTC_1341 1486-1360 280 µM -0.611860446652591 0.263608041200719 no 2473 0.270315046421208 3504 3976547 SGTC_1100 amiodarone 5.07 µM -0.612704734105913 0.263324096214668 no 2474 0.270035795849818 3564 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. SGTC_2724 maprotiline 69.64 µM -0.613226885446856 0.263148568040884 no 2475 0.269863165018959 3546 4011 A tricyclic antidepressant. SGTC_1822 st052468 42 µM -0.61392071540248 0.262915420326714 no 2476 0.269633860256369 3471 2873678 SGTC_504 lovastatin 124 µM -0.61441123186961 0.262750655801705 no 2477 0.269471807751065 3487 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1 SGTC_1014 4130-3005 69.3 µM -0.615041531783813 0.26253901556974 no 2478 0.269263646514617 3531 743608 SGTC_613 3914-0030 117 µM -0.615213880911319 0.262481159886966 no 2479 0.269206740977525 3341 1145395 SGTC_2214 7179297 48.276 µM -0.617217251623484 0.261809129856158 no 2480 0.268545719092665 3557 769744 SGTC_1077 5-fluorocytosine 377 nM -0.617828687332945 0.261604199882196 no 2481 0.268344135537343 3528 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_2040 5100729 123 µM -0.618001252890187 0.261546377377175 no 2482 0.268287256365985 3519 11840 YJR013W | YDR381W GPI14 | YRA1 SGTC_1624 st003710 6.25 µM -0.618680758668366 0.261318755378832 no 2483 0.268063344080541 3561 24207033 SGTC_1608 st001473 40.5 µM -0.618780088414639 0.261285490258838 no 2484 0.26803062059986 3448 7292267 SGTC_2644 guaiazulene 100 µM -0.619646584109076 0.260995396736059 no 2485 0.267745245056224 3542 3515 A coloring agent. SGTC_665 3914-0008 307 µM -0.620014219960622 0.260872366227563 no 2486 0.267624212506658 3511 1069549 SGTC_129 0088-0017 176.636 µM -0.620236197165808 0.260798095295118 no 2487 0.267551146843976 3513 182446 SGTC_309 k408-0051 1.48 µM -0.621002173449374 0.26054189230512 no 2488 0.267299096568609 3534 3640463 SGTC_1687 st020778 55.3625 µM -0.621167825506673 0.260486502216282 no 2489 0.26724460327037 3549 4259299 SGTC_2210 7115885 190.385 µM -0.623126680528692 0.259831968039454 no 2490 0.266600639043855 3560 2927039 SGTC_3013 9080133 71.4286 µM -0.624185185563915 0.259478631374899 no 2491 0.266252987410655 3627 17050193 SGTC_2955 9076254 12.21 µM -0.624509941987658 0.25937027509272 no 2492 0.266146371584911 3490 16459619 SGTC_2865 9030313 51.95 µM -0.625340523440142 0.259093254650375 no 2493 0.26587379443943 3500 42562754 SGTC_2995 9067767 71.4286 µM -0.626495036952526 0.258708448737643 no 2494 0.265495145599423 3513 11673567 SGTC_894 0960-0238 55.9 µM -0.627787526798458 0.258278005775391 no 2495 0.265071569122409 3549 6741907 YDL195W SEC31 SGTC_3043 9092303 49.47 µM -0.628782233943409 0.257946987488512 no 2496 0.264745816305461 3512 25236084 SGTC_2240 6690706 185.951 µM -0.62909776639267 0.257842030712441 no 2497 0.264642526340235 3487 805876 SGTC_1494 4358-1428 177 µM -0.630313147199061 0.257437961087865 no 2498 0.264244861446112 3594 1564571 SGTC_1323 1348-1351 11.2 µM -0.63161406331348 0.25700581892188 no 2499 0.263819547374754 3510 6989654 SGTC_3306 9127676 59.7925 µM -0.631686653310956 0.256981716881821 no 2500 0.263795825502188 3538 41905287 SGTC_3134 9127454 49.47 µM -0.632228330458359 0.256801901076434 no 2501 0.263618843777191 3656 24262820 SGTC_1738 st035555 74 µM -0.632552463547171 0.256694332789069 no 2502 0.263512969020335 3573 5331140 SGTC_2633 5,7-dihydroxyisoflavone 100 µM -0.632614640626945 0.256673701101425 no 2503 0.263492661994408 3580 5377381 SGTC_1672 st016598 6.51 µM -0.633260483708898 0.256459447600107 no 2504 0.263281776976808 3506 4665860 YNL267W PIK1 SGTC_1431 4049-0260 9.09 µM -0.633262445055402 0.256458797080357 no 2505 0.263281136676092 3561 3854841 SGTC_827 3253-0474 693 µM -0.634707229677961 0.255979839063722 no 2506 0.262809688790462 3586 5402065 SGTC_1454 4239-0054 42.6 µM -0.635882835808173 0.255590460579377 no 2507 0.262426395413898 3673 1340767 SGTC_2702 st077768 96.8 µM -0.637481977236513 0.255061297861082 no 2508 0.261905472893752 3510 6484119 SGTC_2022 5136654 200 µM -0.637801562115266 0.254955614613509 no 2509 0.261801431290461 3563 1713771 SGTC_2872 9044037 25.97 µM -0.638691715716382 0.254661371325047 no 2510 0.261511751513779 3562 6465195 SGTC_1544 7-methoxy-4-methylcoumarin 105 µM -0.639171963776323 0.254502697589813 no 2511 0.261355534324939 3525 390807 SGTC_3089 9117425 49.47 µM -0.63918238890588 0.254499253706392 no 2512 0.261352143724825 3529 9401657 SGTC_2779 methotrexate 400 µM -0.639222541725056 0.254485989674586 no 2513 0.261339084898852 3635 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2 SGTC_2615 purpurogallin-4-carboxylic acid 100 µM -0.640784059641987 0.253970440888374 no 2514 0.260831495452068 3621 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase. SGTC_550 4123-0385 25.7 µM -0.644451730567274 0.252761686017535 no 2515 0.259641274345679 3580 5731123 SGTC_3065 9113888 49.47 µM -0.646734446459922 0.252010903186704 no 2516 0.258901912594042 3650 16648368 SGTC_1540 guanosine 70.6 µM -0.64692215899181 0.251949217136392 no 2517 0.258841161824699 3550 6802 Guanosine is a purine nucleoside SGTC_2522 biochanin a 4.94 µM -0.647362233237898 0.251804631280851 no 2518 0.258698766323626 3567 5280373 A possible chelator. SGTC_2885 9057732 51.95 µM -0.650208823693175 0.250870446596773 no 2519 0.257778671102497 3618 6471414 SGTC_2306 7482397 179.52 µM -0.650215969178522 0.25086810392548 no 2520 0.257776363626872 3605 891448 SGTC_2370 9071495 200 µM -0.650621011536325 0.25073532836748 no 2521 0.257645581732742 3541 21791103 SGTC_2459 5811157 9.22 µM -0.650782498779565 0.250682402161091 no 2522 0.257593449614625 3578 2870684 YBR192W RIM2 SGTC_2539 epi(13)torulosol 80 µM -0.651619376525929 0.250408216704952 no 2523 0.257323372340769 3564 6708597 SGTC_3333 9141820 12.094 µM -0.65297668705773 0.249963860533629 no 2524 0.256885654049775 3576 1939433 SGTC_2863 9028737 58.44 µM -0.654192387690821 0.249566220124906 no 2525 0.256493932639093 3580 6460917 SGTC_1963 st076565 50.3 µM -0.654654830626556 0.249415049128064 no 2526 0.256345006644983 3622 4914280 SGTC_480 am 92016 50 µM -0.655990841117267 0.248978585471301 no 2527 0.25591500861762 3544 2129 K+ channel blocker. SGTC_666 0272-0154 136 µM -0.657606379056593 0.248451345876677 no 2528 0.255395547237438 3617 6870312 SGTC_2017 5132927 60.65 µM -0.658842644756163 0.24804828606462 no 2529 0.254998409860335 3587 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis SGTC_35 0133-0054 64.071 µM -0.659559472502777 0.247814738533342 no 2530 0.254768284545707 3552 99677 SGTC_1241 0364-0022 50.8 µM -0.660157827968249 0.247619880035728 no 2531 0.254576276026783 3602 4563895 SGTC_160 3453-0671 289.699 µM -0.660436427988086 0.247529179990104 no 2532 0.254486900897377 3571 5322268 SGTC_3228 9131799 49.47 µM -0.660666850126139 0.247454177980005 no 2533 0.254412993698193 3583 17015818 SGTC_2507 purpurin 79.67 µM -0.661102135686401 0.247312526424685 no 2534 0.254273407882002 3586 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1 SGTC_130 0136-0219 337.655 µM -0.662738731302358 0.246780330101676 no 2535 0.253748949753549 3582 234244 SGTC_2569 tetrandrine 100 µM -0.662901853869384 0.24672731871441 no 2536 0.25369670716895 3572 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_2251 lansoprazole 556 µM -0.663785346725137 0.246440308182789 no 2537 0.253413852766018 3530 3883 Gastric proton pump inhibitor. YBR192W RIM2 SGTC_788 1182-0090 188 µM -0.66427931678259 0.24627991562056 no 2538 0.253255778194201 3683 5715185 SGTC_704 1310-0270 142 µM -0.664314720857149 0.24626842203252 no 2539 0.253244450584112 3601 5718033 SGTC_3178 9107506 49.47 µM -0.664337785685955 0.246260934415158 no 2540 0.253237071085658 3649 8897194 SGTC_929 2805-0021 398 µM -0.6654499466556 0.245900034526665 no 2541 0.25288137391216 3638 3098024 SGTC_2033 5192550 145 µM -0.666320055555525 0.245617879357689 no 2542 0.252603274566586 3593 182073 SGTC_654 1124-0271 80.9 µM -0.667145574089393 0.245350344590816 no 2543 0.252339575951198 3625 5403748 SGTC_1298 1079-1278 263 µM -0.667299814354563 0.24530037564259 no 2544 0.252290322474673 3652 2840950 SGTC_3226 9131256 49.47 µM -0.66904745318206 0.244734578509515 no 2545 0.251732604000573 3547 17178073 SGTC_615 k087-0205 167 µM -0.673702958626172 0.243230796132045 no 2546 0.250250090256139 3610 9642773 SGTC_2689 tacrolimus 100 µM -0.673956702141953 0.243148977814541 no 2547 0.250169420630231 3630 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). SGTC_395 anisomycin 6.25 µM -0.674128522425943 0.243093583681266 no 2548 0.25011480370533 3593 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM -0.674157183503735 0.243084344135126 no 2549 0.250105693755524 3593 6857784 SGTC_3167 9103034 49.47 µM -0.675893463973455 0.242524969283535 no 2550 0.249554143892733 3641 5127859 SGTC_1543 azetidyl-2-carboxylic acid 198 µM -0.676611708885957 0.242293777416917 no 2551 0.249326174064143 3644 16486 A toxic proline analog. SGTC_1441 4106-0040 13 µM -0.677417498988369 0.242034548343142 no 2552 0.249070549363705 3633 2904180 SGTC_1801 st050089 28.441 µM -0.678372786641934 0.241727419682448 no 2553 0.248767679555595 3660 5008493 YIL048W | YNL267W NEO1 | PIK1 SGTC_1561 5-methoxyflavone 52.9 µM -0.678477337938227 0.241693818885162 no 2554 0.2487345439299 3610 94525 SGTC_2095 5432005 200 µM -0.679322462741354 0.241422304952563 no 2555 0.248466783349136 3650 783734 SGTC_2168 5727979 200 µM -0.679350066113301 0.24141343958989 no 2556 0.248458040374109 3588 695210 SGTC_860 0443-0016 25.1 µM -0.680703396088215 0.240979008159115 no 2557 0.248029593508001 3661 5337942 SGTC_354 2783-3500 4.88 µM -0.682894154919996 0.240276656465976 no 2558 0.247336863838378 3629 6740761 SGTC_401 neomycin 50 µM -0.683287763276852 0.24015058493886 no 2559 0.247212512462971 3627 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis. SGTC_2323 6148992 148.28 µM -0.683630794152345 0.240040742631022 no 2560 0.247104167132485 3615 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42 SGTC_518 1021-0119 62.6 µM -0.684625585769943 0.239722354233103 no 2561 0.246790108705944 3614 1097762 SGTC_3160 9100216 49.47 µM -0.685766947261174 0.239357339418468 no 2562 0.246430041176546 3600 17191039 SGTC_2474 5321570 43.32 µM -0.686463886528671 0.239134603085418 no 2563 0.246210314906137 3666 2841384 SGTC_3275 9138069 49.47 µM -0.687340760673351 0.238854521973954 no 2564 0.245934009299318 3687 17617007 SGTC_2978 9011784 42.97 µM -0.687410181775346 0.238832355946415 no 2565 0.245912141617472 3714 2994934 SGTC_933 2914-0560 114 µM -0.687953475326595 0.238658922199996 no 2566 0.245741039921067 3674 463887 SGTC_3332 9141069 11.198 µM -0.688183765139463 0.238585428372081 no 2567 0.245668533086724 3618 17332883 SGTC_638 3970-0837 4.09 µM -0.688695430932847 0.238422181613284 no 2568 0.245507476047104 3648 4118451 YLR208W SEC13 SGTC_2070 5230947 200 µM -0.688810093696106 0.238385606896946 no 2569 0.245471391431661 3720 2835538 SGTC_606 k015-0008 38.6 µM -0.690451833939824 0.237862267571832 no 2570 0.244955044928837 3707 1970475 SGTC_1726 st035556 14.5795 µM -0.691690497728591 0.237467834736136 no 2571 0.24456585781393 3727 5919439 SGTC_368 fentichlor 4.58 µM -0.694659797506134 0.236523771972809 no 2572 0.243634264070384 3641 7329 A pesticide. SGTC_63 0099-0242 26.702 µM -0.694773599662997 0.236487630719735 no 2573 0.243598597733643 3692 3898502 YLR359W ADE13 SGTC_2940 9060638 45.86 µM -0.696733229997874 0.23586576894181 no 2574 0.242984879385269 3659 4027022 SGTC_2574 2',4'-dihydroxychalcone 14.64 µM -0.697108887444108 0.235746662257115 no 2575 0.242867326342022 3701 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_482 fipronil 114 µM -0.697516892285528 0.235617337025475 no 2576 0.242739685822629 3704 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels. SGTC_2468 5987765 72.9 µM -0.699379372829603 0.235027484194078 no 2577 0.242157487587516 3704 26772094 SGTC_928 2764-0428 58.7 µM -0.700309748609724 0.23473313738573 no 2578 0.241866942487754 3703 662578 SGTC_2651 TUB2.036 5 µM -0.700612908175982 0.234637269592197 no 2579 0.241772310295507 3760 15992207 YFL037W TUB2 SGTC_3135 9127742 49.47 µM -0.70152377587719 0.23434935727338 no 2580 0.241488101062702 3697 3643468 SGTC_2996 9066192 71.4286 µM -0.703161573746504 0.233832164856347 no 2581 0.240977531623845 3699 6472854 SGTC_2396 5342950 42.78 µM -0.703597925274414 0.233694478265794 no 2582 0.240841601888283 3684 1886677 SGTC_2857 9024691 58.44 µM -0.703860959950743 0.233611501882816 no 2583 0.24075968298498 3719 16478292 SGTC_2086 5274770 176.623 µM -0.704726707872047 0.233338510212849 no 2584 0.240490163596262 3705 689278 SGTC_1357 1503-1303 39.5 µM -0.704906357671421 0.233281884385633 no 2585 0.24043425670279 3691 292895 SGTC_346 4513-0042 7.16 µM -0.705263401735918 0.23316936632118 no 2586 0.240323165853963 3672 2827372 SGTC_592 k241-0073 46.5 µM -0.706043006084767 0.232923788297596 no 2587 0.240080696633132 3696 4230158 SGTC_3129 9127257 49.47 µM -0.706715129806478 0.23271218241427 no 2588 0.239871762678221 3635 837894 SGTC_781 4335-2806 94.4 µM -0.706791697355547 0.232688083300034 no 2589 0.239847967460641 3792 845254 SGTC_1705 st027868 56.3335 µM -0.707036659155632 0.232610992561415 no 2590 0.239771848307412 3698 292948 SGTC_1036 k216-0215 33.5 µM -0.707947196505369 0.232324566285103 no 2591 0.239489024545275 3690 622330 SGTC_1170 0310-0127 64.8 µM -0.707964508838077 0.232319122273781 no 2592 0.239483648893415 3687 774975 SGTC_1735 st034310 56.75 µM -0.708279487509937 0.232220086925091 no 2593 0.239385856381313 3775 871153 SGTC_802 4112-3352 742 µM -0.710700477428929 0.23145966591958 no 2594 0.238634931876239 3761 704594 SGTC_1378 2093-0007 380 nM -0.711240593084048 0.231290207872276 no 2595 0.238467578901584 3716 3618014 SGTC_3156 9099931 49.47 µM -0.711255517616212 0.231285526372578 no 2596 0.238462955499196 3718 18111053 SGTC_1175 0741-0056 27.6 µM -0.712082447635747 0.231026219104841 no 2597 0.238206861348226 3755 765927 SGTC_2434 5670830 169.91 µM -0.712865263255486 0.230780894748384 no 2598 0.23796456800701 3697 1549830 SGTC_3073 9114972 49.47 µM -0.71290669969004 0.230767913158216 no 2599 0.23795174656648 3622 41905075 SGTC_2431 5490079 200 µM -0.713640575318054 0.230538065393693 no 2600 0.237724730365492 3733 5722345 SGTC_65 0798-0905 34.986 µM -0.713847410205391 0.230473308412816 no 2601 0.237660769779384 3791 3602145 SGTC_3172 9105863 49.47 µM -0.714012721192414 0.230421559269862 no 2602 0.237609656626112 3677 2348785 SGTC_451 chloral hydrate 100 µM -0.714352911081829 0.230315086273561 no 2603 0.237504490960241 3774 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1 SGTC_2881 9058953 51.95 µM -0.715837530547261 0.229850750642568 no 2604 0.237045837653953 3684 17122249 SGTC_2284 7945075 39.21 µM -0.716382017243823 0.229680586212279 no 2605 0.236877747852958 3770 1245402 SGTC_961 1252-1571 372 µM -0.71812416525802 0.229136599815518 no 2606 0.236340365676864 3702 6813498 SGTC_2271 7849410 118.62 µM -0.718143288776716 0.229130632501759 no 2607 0.23633447057175 3672 972430 SGTC_1222 0366-0074 1.18 µM -0.719327430993932 0.228761301925346 no 2608 0.235969599120243 3735 286520 SGTC_794 k038-0031 316 µM -0.720255608797379 0.22847203972741 no 2609 0.235683815530145 3730 6624242 SGTC_3145 9085516 49.47 µM -0.722631557146394 0.227732523780488 no 2610 0.23495313752745 3736 25236195 SGTC_1250 0485-0349 40.2 µM -0.723090671890218 0.227589779411364 no 2611 0.234812089911869 3720 6842794 YDL195W SEC31 SGTC_1389 3405-0187 19 µM -0.724439395527672 0.227170736309694 no 2612 0.234398010616925 3675 799890 SGTC_723 4182-0001 115 µM -0.725088498624103 0.226969217662953 no 2613 0.234198869913485 3694 744821 YLR208W SEC13 SGTC_2409 alverine citrate 63.97 µM -0.726310431875412 0.226590133499626 no 2614 0.233824242826623 3860 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_3021 9087658 49.47 µM -0.727131127507175 0.226335727296336 no 2615 0.233572815944587 3687 25237042 SGTC_2272 7805186 180 µM -0.728276424864052 0.22598096812079 no 2616 0.233222195378397 3686 2956062 YPR165W RHO1 SGTC_3215 9129942 49.47 µM -0.729148316368296 0.225711108082919 no 2617 0.232955471066081 3652 17682944 SGTC_960 1222-0186 7.7 µM -0.729297573957238 0.225664929495597 no 2618 0.23290982798584 3739 3126296 SGTC_2339 9000433 200 µM -0.729700417903755 0.225540320882432 no 2619 0.232786662812333 3734 2988954 SGTC_174 3553-0389 74.3 µM -0.734408508511899 0.224086893731813 no 2620 0.23134990133842 3702 738071 SGTC_1366 1683-0113 21.9 µM -0.735879893518939 0.223633758315313 no 2621 0.230901897255939 3745 708623 SGTC_3353 9151644 39.2805 µM -0.738186353261155 0.222924498559669 no 2622 0.230200607251984 3778 4909158 SGTC_2617 dihydrotanshinone i 20.83 µM -0.738311609467034 0.222886017724893 no 2623 0.230162556647379 3762 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12 SGTC_494 Boc-Gly-Val-Val-CHO 140 µM -0.738858876436534 0.222717932406734 no 2624 0.229996347964407 3761 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA. SGTC_1470 k295-0292 231 µM -0.741080649389188 0.222036288707704 no 2625 0.229322270840061 3799 5045612 SGTC_158 k038-0087 26.446 µM -0.741479741542246 0.221913972867456 no 2626 0.229201305307521 3690 X158 SGTC_3143 9086658 49.47 µM -0.742070731245275 0.221732913967521 no 2627 0.229022241035336 3813 25236626 SGTC_1723 st034307 2.5525 µM -0.742210923270026 0.221689976345538 no 2628 0.228979775702255 3802 867466 SGTC_1787 fluconazole 80 µM -0.742484378236674 0.221606236994507 no 2629 0.228896956627968 3636 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C SGTC_36 0335-0881 14.2 µM -0.74381148612298 0.221200097289551 no 2630 0.228495265143934 3693 23828853 SGTC_1245 0418-0076 17.2 µM -0.74391648434732 0.221167982484518 no 2631 0.228463501000416 3767 6790114 SGTC_1462 k081-0014 26.5 µM -0.74463307999659 0.220948875449935 no 2632 0.228246782188626 3501 3270634 SGTC_1458 k015-0034 6.33 µM -0.745559403235005 0.220665826095093 no 2633 0.227966807139326 3781 3598957 SGTC_1644 st010134 20.9 µM -0.745800965941119 0.220592047825301 no 2634 0.227893828186005 3742 3818134 SGTC_1163 k060-0048 49.9 µM -0.746719222846982 0.220311722087538 no 2635 0.227616531890788 3757 6809982 SGTC_2849 9019321 12.99 µM -0.748790874032411 0.219680038507506 no 2636 0.226991630524007 3742 16489627 SGTC_2769 toremifene 3.73 µM -0.749452610964278 0.219478482419124 no 2637 0.226792225538587 3764 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_1316 1272-0050 65.9 µM -0.749924495202505 0.219334817797258 no 2638 0.226650090341483 3748 7340392 SGTC_2287 7945887 168.79 µM -0.750100886296483 0.219281129607651 no 2639 0.226596972885999 3788 1245853 SGTC_1856 st057054 55.7 µM -0.751515122775408 0.218850951325849 no 2640 0.226171351504956 3774 1266018 SGTC_254 nsc-64875 3.808 µM -0.753300056283751 0.218308709265937 no 2641 0.225634812499973 3788 56993 SGTC_569 4130-2812 160 µM -0.753951672894899 0.218110948732056 no 2642 0.225439120527007 3632 743552 SGTC_889 0919-1524 82.7 µM -0.75398187972293 0.218101783701483 no 2643 0.225430051214076 3806 3905452 SGTC_545 4218-0007 221 µM -0.754693837542399 0.217885833405577 no 2644 0.225216352462033 3711 2840508 SGTC_1151 3909-8316 15.3 µM -0.754760087110885 0.217865744929145 no 2645 0.225196473061941 3803 800431 SGTC_100 0086-0128 49.5915 µM -0.756015250053262 0.217485350948156 no 2646 0.224820026218427 3769 93297 SGTC_1952 st077036 64.1 µM -0.756959532752255 0.217199426286116 no 2647 0.224537053510431 3765 2937007 SGTC_2394 5221648 200 µM -0.757897731324852 0.216915559035512 no 2648 0.224256104271312 3840 788586 SGTC_2133 5320837 200 µM -0.757942238899539 0.216902097874503 no 2649 0.224242781169494 3748 2841355 SGTC_476 mead acid 10 µM -0.7605611575185 0.216110865637787 no 2650 0.223459613707157 3789 5312531 An omega 9 fatty acid. SGTC_600 1495-0418 41.6 µM -0.761500425661448 0.21582750010574 no 2651 0.223179112362387 3776 5377768 SGTC_3241 9133421 49.47 µM -0.761631233488628 0.215788054098724 no 2652 0.223140064056657 3789 17018221 SGTC_2300 7976697 71.57 µM -0.763781749340423 0.215140150441323 no 2653 0.222498657305038 3707 2236109 SGTC_2883 9059145 45.46 µM -0.764208866313295 0.21501160393521 no 2654 0.22237139186742 3771 16476510 SGTC_1312 1218-2183 165 µM -0.764907471095072 0.214801445743036 no 2655 0.222163322392321 3780 6744073 SGTC_2567 aureobasidin a 60 nM -0.766267584382382 0.214392631395138 no 2656 0.22175855094576 3921 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1 SGTC_3051 9093778 49.47 µM -0.770491392605348 0.213125953607288 no 2657 0.220504229448483 3800 17217378 SGTC_1706 st031321 9.9705 µM -0.771413384441819 0.212850039054064 no 2658 0.220230972097398 3814 6103185 SGTC_759 3486-0358 89.3 µM -0.771992438494875 0.212676858434226 no 2659 0.220059453002923 3780 875103 SGTC_828 2074-0507 139 µM -0.77230332344517 0.212583914456667 no 2660 0.219967398741697 3846 X828 SGTC_3138 9097216 49.47 µM -0.772779540679271 0.212441587786964 no 2661 0.219826431793191 3782 25237486 SGTC_2782 7736369 71.43 µM -0.772845818239848 0.212421783878814 no 2662 0.219806816821527 3844 2950836 YOL077C BRX1 SGTC_447 ml7 120 µM -0.773758721084239 0.212149115892938 no 2663 0.219536743707767 3812 4216 Selective myosin light chain kinase inhibitor. SGTC_2681 menadione 3.18 µM -0.774370537675092 0.211966491642238 no 2664 0.219355850655575 3825 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_3320 9137005 35.139 µM -0.776576581720582 0.211308762292471 no 2665 0.21870431121626 3832 4908713 SGTC_2008 4012253 172 µM -0.776779559677584 0.211248304783864 no 2666 0.21864441912642 3810 603940 SGTC_1516 st013856 110 µM -0.777329299728143 0.211084614192157 no 2667 0.218482256418738 3839 5281404 A mutagen and neurotoxin. SGTC_651 3253-0966 34.4 µM -0.77746982834968 0.211042782325274 no 2668 0.218440814304935 3827 781462 SGTC_97 0535-0701 19.132 µM -0.777777673938933 0.210951161352852 no 2669 0.218350045974616 3723 2832013 YGL099W LSG1 SGTC_165 k038-0023 64.381 µM -0.777918142161514 0.21090936296438 no 2670 0.218308636112334 3793 46368543 SGTC_2944 9067346 25.62 µM -0.778048960799358 0.21087044031958 no 2671 0.218270075005121 3731 6473075 SGTC_1429 4049-0205 9.46 µM -0.778892705610763 0.210619501008006 no 2672 0.218021460598413 3815 22774478 SGTC_2726 cimetidine 79.27 µM -0.780150758498979 0.210245667336356 no 2673 0.217651071209977 3787 2756 A P450 inhibitor, histamine H2-receptor antagonist. SGTC_2160 5660466 132.927 µM -0.780340269572132 0.210189387420442 no 2674 0.217595307829424 3735 2859134 SGTC_258 haloperidol 50.781 µM -0.780743471719776 0.210069676194354 no 2675 0.217476693571078 3829 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_1475 4092-1048 11.7 µM -0.781209869511172 0.209931252080073 no 2676 0.217339534948811 3823 2881759 SGTC_2760 etidronate 98.04 µM -0.781220889868776 0.209927981951339 no 2677 0.217336294677754 3805 3305 A chelator and antioxidant. SGTC_1670 st016595 4.04 µM -0.781769876347627 0.20976511619806 no 2678 0.217174913721559 3809 597879 SGTC_1179 1021-1431 9.29 µM -0.783451270801072 0.209266765633582 no 2679 0.216681079179424 3834 2840958 SGTC_23 0213-0011 39.996 µM -0.783617782579769 0.209217450956562 no 2680 0.216632209148751 3820 627608 SGTC_636 0kpi-0074 126 µM -0.78463042202697 0.208917691664976 no 2681 0.216335143943335 3837 616434 SGTC_2971 9092186 9.93 µM -0.786610636171051 0.20833224470157 no 2682 0.215754915515095 3836 25236400 SGTC_2457 5731572 11.68 µM -0.786700445690503 0.208305715630412 no 2683 0.215728621562495 3875 2865357 SGTC_3171 9103192 49.47 µM -0.787580439840726 0.208045877284708 no 2684 0.215471079855429 3832 13018434 SGTC_1042 0350-0096 82 µM -0.789224767307243 0.20756086516767 no 2685 0.214990324349996 3822 3122515 SGTC_2330 7979373 200 µM -0.789489890611716 0.207482726790518 no 2686 0.214912868043753 3784 1863007 SGTC_1482 3346-2049 8.48 µM -0.789705180407936 0.207419288370899 no 2687 0.21484998262365 3831 3826804 SGTC_2818 7996756 12.99 µM -0.790608033822912 0.207153373748614 no 2688 0.214586378635716 3811 2241621 SGTC_2232 chlorophetanol 41.5365 µM -0.792722078726667 0.206531520064202 no 2689 0.213969881902321 3891 15907 An antifungal of unknown mechanism. YFR051C RET2 SGTC_867 0518-0118 155 µM -0.793850740571797 0.206199973512358 no 2690 0.213641164709313 3832 6848158 SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM -0.795518874263739 0.205710534273415 no 2691 0.213155868141904 3804 16623 A steroid. SGTC_1364 1653-0028 37.6 µM -0.795521861177634 0.205709658515931 no 2692 0.213154999760408 3829 5718652 SGTC_253 dyclonine 31.25 µM -0.796035814050354 0.205559001457924 no 2693 0.213005609652631 3894 3180 An oral anasthetic. SGTC_967 1306-0166 352 µM -0.796842330473559 0.205322716175019 no 2694 0.212771303613619 3774 4437607 SGTC_21 0849-0113 22.993 µM -0.798628542450477 0.204799983960021 no 2695 0.212252916157398 3777 1560156 SGTC_2813 7971799 71.43 µM -0.799214886663261 0.204628563917144 no 2696 0.212082910703281 3912 2234054 SGTC_1308 1187-1617 41.4 µM -0.800971841419956 0.204115422647128 no 2697 0.211573973792004 3823 2882570 SGTC_2841 9004761 38.96 µM -0.802406957857163 0.203696847693362 no 2698 0.211158794790898 3831 2991039 SGTC_572 0960-0087 17.7 µM -0.80409394036581 0.203205466868718 no 2699 0.21067136196062 3850 6796365 SGTC_181 1447-1644 8.07 µM -0.805070618429026 0.20292130575019 no 2700 0.210389464831871 3835 534600 SGTC_1668 st014914 51.6 µM -0.806697681279067 0.202448444794506 no 2701 0.20992034017196 3853 2839556 SGTC_1182 1222-0449 220 µM -0.807155930545283 0.202315386283902 no 2702 0.209788325995514 3844 658318 SGTC_549 1661-1316 519 µM -0.807175160113648 0.202309803877562 no 2703 0.209782787336194 3840 2857282 SGTC_2814 7977482 42.97 µM -0.80897917442238 0.201786502484849 no 2704 0.209263562656744 3930 6456762 SGTC_472 calcifediol 10 µM -0.809799590362647 0.20154878782145 no 2705 0.209027684042368 3888 5283731 A vitamin D metabolite. SGTC_1052 3253-3998 198 µM -0.810341461187537 0.201391873361046 no 2706 0.208871976117354 3801 5450317 SGTC_479 n-linoleoylglycine 10 µM -0.810896041937202 0.201231354212224 no 2707 0.20871268674429 3877 6433346 An anti-infammatory. SGTC_1139 k015-0024 46.9 µM -0.812078620141433 0.200889322303926 no 2708 0.208373260099424 3825 2766652 SGTC_1727 st034309 9.9045 µM -0.813051457023301 0.200608214644433 no 2709 0.208094278199181 3973 870305 SGTC_170 4197-0004 226 µM -0.814823799284428 0.200096692093972 no 2710 0.207586587981684 3893 218692 SGTC_3331 9141060 1.957 µM -0.815209575848088 0.199985455618537 no 2711 0.207476178753889 3832 4906567 YPR165W RHO1 SGTC_3046 9092212 49.47 µM -0.816237679897414 0.199689189302846 no 2712 0.207182105002861 3890 25236637 SGTC_488 nitrendipine 139 µM -0.81660905520141 0.199582235914063 no 2713 0.207075939305137 3893 4507 Dihydropyridine L-type calcium channel blocker. SGTC_3296 9122258 64.045 µM -0.820295360800887 0.198522477218562 no 2714 0.20602387521415 3897 4730474 SGTC_3284 9108171 64.8615 µM -0.821068062374233 0.198300767980419 no 2715 0.205803750309443 3841 8687505 SGTC_3067 9117431 49.47 µM -0.823998747589513 0.197461233320662 no 2716 0.204970134791475 3909 17150885 SGTC_3120 9124077 49.47 µM -0.827051933216905 0.196588896409498 no 2717 0.204103813287144 3932 18774327 YGL155W CDC43 SGTC_1362 1611-0397 101 µM -0.827521420328542 0.196454964933266 no 2718 0.203970793128148 3833 27816 SGTC_3053 9095903 49.47 µM -0.828181818905658 0.196266665405666 no 2719 0.203783769330952 3946 17174018 SGTC_3240 9133527 49.47 µM -0.830070299717772 0.195728806792752 no 2720 0.203249519065562 3818 17617455 SGTC_343 4130-2827 29.8 µM -0.830439977921418 0.195623623475961 no 2721 0.203145035209231 3932 1118244 SGTC_2077 5212015 200 µM -0.832034674412925 0.195170283217677 no 2722 0.20269468640749 3758 780900 SGTC_885 0865-0106 16.8 µM -0.832482228646719 0.195043167349406 no 2723 0.20256840256111 3812 2793380 SGTC_3049 9092223 49.47 µM -0.835919642325307 0.194068540196563 no 2724 0.201600055703891 3862 8623917 SGTC_980 1473-0395 201 µM -0.837095264035238 0.193735892356685 no 2725 0.201269511138884 3783 768876 SGTC_2343 7990716 14.84 µM -0.8373322044218 0.193668891045858 no 2726 0.201202930979653 3880 6456862 SGTC_1526 st051518 75 µM -0.837508475351757 0.193619054833709 no 2727 0.201153407482855 3893 673993 SGTC_1842 st055362 61.2 µM -0.839731016086724 0.192991357996491 no 2728 0.200529609754568 3860 676032 SGTC_2815 7968870 71.43 µM -0.839849505015644 0.192957928914326 no 2729 0.200496386264592 3878 2977326 YHR190W ERG9 SGTC_1832 st054113 55 µM -0.84003736439646 0.192904935711758 no 2730 0.20044371854754 3876 1251267 SGTC_1681 tripelennamine 100 µM -0.840248634740116 0.192845349138123 no 2731 0.200384497328979 3851 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist. SGTC_2314 7727897 200 µM -0.842306797896472 0.192265454379832 no 2732 0.199808123470756 3909 900724 SGTC_3235 9132602 49.47 µM -0.843591468146682 0.191904035215735 no 2733 0.199448866770222 3904 4912240 SGTC_1995 st072814 61.1 µM -0.84456002714696 0.191631823498965 no 2734 0.199178267526234 3887 5769371 SGTC_806 3966-4455 5.86 µM -0.84504591331705 0.191495355213813 no 2735 0.199042602363221 3882 714982 SGTC_1160 4092-0570 10.5 µM -0.845534053248309 0.191358313900432 no 2736 0.198906364003702 3882 4994975 SGTC_1255 0566-0045 221 µM -0.845703492758962 0.191310759192473 no 2737 0.198859087098901 3955 2788469 SGTC_703 3875-0075 71.8 µM -0.846170993326478 0.191179588562032 no 2738 0.198728680517734 3924 2850814 SGTC_1803 st050068 52.4 µM -0.84619954916346 0.191171578194031 no 2739 0.198720716703398 3961 3984059 YIL048W | YNL267W NEO1 | PIK1 SGTC_2774 tamoxifen 10.92 µM -0.847941782582854 0.190683243255421 no 2740 0.19823519683131 3912 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  SGTC_684 1140-0066 328 µM -0.848594089127105 0.190500603795312 no 2741 0.198053598581656 3959 6813534 SGTC_681 1642-0006 26.6 µM -0.848705307422936 0.190469474480374 no 2742 0.198022646099011 3914 4446530 SGTC_236 1509-0011 5.31 µM -0.851765453716153 0.189614184130905 no 2743 0.197172141976035 3967 3107280 SGTC_695 3505-6186 243 µM -0.852177882694872 0.189499093943379 no 2744 0.197057685157486 3910 1819379 SGTC_1219 1469-0211 33.1 µM -0.852712768346946 0.189349895702872 no 2745 0.196909304209945 3917 6822282 SGTC_1097 itavastatin 7.23 µM -0.855788436305063 0.188493388760783 no 2746 0.196057406302005 3904 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49 SGTC_171 k064-0041 9.68 µM -0.855948351929893 0.188448921160099 no 2747 0.196013174127961 3936 53325 SGTC_1302 1159-0335 255 µM -0.857052203413055 0.18814215061917 no 2748 0.195708017315985 3926 649284 SGTC_409 arachidonic acid 100 µM -0.857255702212607 0.188085630083497 no 2749 0.195651792112173 3917 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes. SGTC_1834 st055981 52.8 µM -0.858463864954725 0.187750286189832 no 2750 0.195318187720026 3969 471719 YDL150W RPC53 SGTC_2256 7954252 200 µM -0.860508352544664 0.187183649522342 no 2751 0.194754440643221 3944 2972920 SGTC_2736 butenafine 14.65 µM -0.862666724634891 0.186586598296466 no 2752 0.194160366324009 3867 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_3271 9137798 49.47 µM -0.863881510915599 0.186251082010772 no 2753 0.193826492286189 3845 6498326 SGTC_257 daunorubicin 18.5 µM -0.865841482058245 0.185710539152415 no 2754 0.193288548670358 3962 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_85 0868-0259 160.055 µM -0.866060199339085 0.18565027926438 no 2755 0.193228574979654 3861 83173 SGTC_1286 0929-0070 131 µM -0.867184765246389 0.18534063609563 no 2756 0.192920391114308 4029 1420408 SGTC_2194 5927483 104.545 µM -0.868387345944597 0.185009866983601 no 2757 0.192591159913757 3928 760979 SGTC_646 4092-0839 27.3 µM -0.870097053937321 0.184540244624412 no 2758 0.192123683775449 3975 877796 SGTC_2785 7756463 72.73 µM -0.871723783783284 0.184094103628485 no 2759 0.191679541029574 3899 2201551 SGTC_2320 7373003 200 µM -0.872088135191263 0.183994270050287 no 2760 0.191580149164219 4012 5415828 SGTC_1372 2752-0194 270 µM -0.872589924049645 0.183856833316564 no 2761 0.191443317258987 3895 823334 SGTC_3159 9100096 49.47 µM -0.872621220669791 0.183848263492898 no 2762 0.191434785024074 3904 25236875 SGTC_484 loperamide 105 µM -0.874015464239489 0.183466736015075 no 2763 0.19105491608837 3908 3955 An opioid-receptor agonist. SGTC_1276 0871-0068 94.2 µM -0.878618689332477 0.182210595657115 no 2764 0.189804029441487 3946 3414906 SGTC_172 1112-0046 2.638 µM -0.878660718968046 0.182199151317637 no 2765 0.189792631502139 3909 2802135 YIL048W NEO1 SGTC_2034 5197015 53.07 µM -0.882411517658892 0.181179647833043 no 2766 0.188777154749949 3940 780676 SGTC_2104 5389443 200 µM -0.884205377923546 0.180693324812121 no 2767 0.188292677885128 4013 2244536 SGTC_1756 st041558 35.5 µM -0.884281496176183 0.180672706953768 no 2768 0.188272137225351 4029 3955792 SGTC_989 1501-0895 10.3 µM -0.885776377819401 0.180268093109402 no 2769 0.187869020705529 3894 2830112 SGTC_776 4476-4378 112 µM -0.886143539302414 0.180168801980897 no 2770 0.187770091875701 4010 2892008 SGTC_2975 9084847 53.72 µM -0.888482686359175 0.179537034955498 no 2771 0.18714058248288 4027 27211724 SGTC_1653 st012112 65 µM -0.892837048370008 0.17836470361991 no 2772 0.185972221488022 3943 720429 SGTC_3175 9106517 49.47 µM -0.894259147353176 0.177982876997224 no 2773 0.185591626203737 3990 41468073 SGTC_1153 4055-0057 267 µM -0.89438931523074 0.177947953324823 no 2774 0.185556813633525 4001 882706 SGTC_3236 9132701 49.47 µM -0.894836141777421 0.177828103910019 no 2775 0.185437343551704 3964 24282524 SGTC_2203 7227154 166.4 µM -0.895350585317568 0.177690181095367 no 2776 0.185299853548321 3947 896304 SGTC_379 3970-0972 5.9 µM -0.896799171598725 0.177302176429595 no 2777 0.184913045048921 3963 2898042 YBL034C STU1 SGTC_2427 5545055 42.75 µM -0.897109516684375 0.17721911996024 no 2778 0.184830240518416 3938 5372858 SGTC_2005 4024620 188 µM -0.897653707759051 0.17707353951571 no 2779 0.184685098164666 3956 236743 SGTC_2734 clemastine 41.6 µM -0.898561768154589 0.176830786060565 no 2780 0.184443065281698 3983 26987 Clemastine is a selective histamine H1 antagonist. SGTC_829 1635-0120 117 µM -0.899921942943185 0.176467561767381 no 2781 0.184080895907779 3982 285054 SGTC_2673 kobusone 100 µM -0.902131822763407 0.175878437309398 no 2782 0.183493423006342 4017 6710676 An epoxy ketone and protein crosslinker. SGTC_2007 4011539 71.82 µM -0.902641179612299 0.175742826411954 no 2783 0.183358181838205 3951 45595301 SGTC_874 0599-0792 117 µM -0.903443718216377 0.175529293405424 no 2784 0.183145223066227 3973 765305 SGTC_3222 9128301 49.47 µM -0.905829165146203 0.174895564186535 no 2785 0.182513140735595 3993 4911358 SGTC_344 k064-0035 6.43 µM -0.906215645671914 0.174793026774361 no 2786 0.182410861707638 3931 5088750 SGTC_1 0258-0098 57.368 µM -0.908617948476302 0.174156526187083 no 2787 0.181775914498221 3913 6790032 YDR047W HEM12 SGTC_89 0302-0250 142.109 µM -0.909383296792216 0.173954053633372 no 2788 0.181573917781845 4066 4203518 YLR208W SEC13 SGTC_1114 scopoletin 1.73284 µM -0.909798577516417 0.173844253969702 no 2789 0.181464372459701 3998 5280460 A coumarin with genotoxic properties. SGTC_557 1315-0110 16.2 µM -0.912176827493336 0.173216297163615 no 2790 0.180837820114883 3957 6833801 SGTC_2646 retinol 96.75 µM -0.912416956059933 0.173152973629718 no 2791 0.180774633459423 3991 445354 A vitamin A analog and teratogen. SGTC_2364 9055074 200 µM -0.913910047295452 0.172759566240854 no 2792 0.180382056903362 4015 6470630 SGTC_3268 9137683 49.47 µM -0.914202039431673 0.172682697300509 no 2793 0.180305346363767 4022 1953228 SGTC_1594 piperine 70.1 µM -0.915319989810649 0.172388590761209 no 2794 0.180011833968684 3959 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_2576 guaiol 23.12 µM -0.91569753505507 0.172289339674654 no 2795 0.179912779119085 3932 227829 SGTC_380 3970-0968 6 µM -0.918245859979929 0.171620376385555 no 2796 0.179245082166505 3891 2891601 SGTC_2254 7938975 95.19 µM -0.919799494665302 0.171213345608447 no 2797 0.178838773743595 4076 2969277 SGTC_716 1683-5115 658 µM -0.920701551360736 0.170977302718943 no 2798 0.178603133011759 3940 723597 SGTC_1055 3448-0672 86 µM -0.92087753913593 0.170931275944478 no 2799 0.178557183220465 4037 748378 SGTC_1606 st000094 49.2 µM -0.921243833568152 0.170835502945078 no 2800 0.178461568906014 4008 1242210 SGTC_1334 1486-0610 236 µM -0.924456331085094 0.169997020464109 no 2801 0.177624388804787 4085 3742339 SGTC_2368 9071271 200 µM -0.925465723251413 0.169734108208148 no 2802 0.177361852697821 4005 27209959 SGTC_2350 9023895 38.85 µM -0.929619758368801 0.168654870373612 no 2803 0.176283996811218 4030 2997209 SGTC_678 1218-2179 85.9 µM -0.929920559633856 0.168576892421084 no 2804 0.176206108570362 3981 6820081 YOR116C RPO31 SGTC_1387 3342-1166 1.8 µM -0.930998087983324 0.168297750555482 no 2805 0.175927276607783 3991 3418228 SGTC_3093 9117344 49.47 µM -0.931074168914739 0.168278052458464 no 2806 0.175907599715017 4057 24824913 SGTC_719 2810-4230 27.3 µM -0.931708104367865 0.168113978034871 no 2807 0.175743698503066 3999 721079 SGTC_1034 k072-0165 12.7 µM -0.933047128537899 0.167767751852374 no 2808 0.175397817828791 4059 5835461 SGTC_1233 0325-0408 14.2 µM -0.933153398627375 0.167740293694715 no 2809 0.175370385909222 4046 12874 SGTC_1155 4088-0394 48.2 µM -0.934817914816512 0.167310592241826 no 2810 0.174941072748211 3994 2326248 SGTC_1682 st012968 530 nM -0.935781911637112 0.16706205734334 no 2811 0.174692743247906 4029 24207270 SGTC_1715 st032160 10.2275 µM -0.936529454399111 0.16686949197786 no 2812 0.174500327334887 3967 5289825 SGTC_1586 deoxycorticosterone acetate 53.7 µM -0.940387476526932 0.165877951390885 no 2813 0.17350942183036 4024 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE. SGTC_3036 9090181 49.47 µM -0.942196704999248 0.16541428049048 no 2814 0.173045970290841 4043 25236586 SGTC_1850 st056238 17 µM -0.943452849696418 0.165092848127624 no 2815 0.172724660825806 4027 5393177 SGTC_2217 6934799 96.0675 µM -0.943735135359731 0.165020670292892 no 2816 0.172652507296248 3974 675606 SGTC_2680 butyl paraben 22.24 µM -0.945152701558744 0.16465852069074 no 2817 0.172290461383005 4085 7184 An antifungal and steroid mimetic. SGTC_1662 st014054 52 µM -0.946951074774542 0.16419982686837 no 2818 0.171831855072208 4059 2838777 SGTC_2334 9017922 200 µM -0.94715011139504 0.164149111486701 no 2819 0.171781146352402 4105 3163164 SGTC_1465 k213-0056 144 µM -0.953575963077157 0.16251723682869 no 2820 0.170149163860496 3911 24048857 YMR208W ERG12 SGTC_1657 st012939 43.4 µM -0.954610128083949 0.162255595417718 no 2821 0.169887446716799 4053 24207257 SGTC_3152 9099253 49.47 µM -0.956862295076491 0.161686751705869 no 2822 0.169318382244983 3972 25236131 SGTC_2695 st077686 51.995 µM -0.957328470217397 0.161569169540257 no 2823 0.169200744836684 4075 2876092 SGTC_1898 st060199 18.6 µM -0.957494576319211 0.161527286495849 no 2824 0.169158841317813 4009 688866 SGTC_721 1187-1332 279 µM -0.957731432665782 0.161467576281148 no 2825 0.169099101189648 3987 25730 SGTC_2656 pseudo-anisatin 100 µM -0.957938679095064 0.161415342375425 no 2826 0.169046840417541 4066 6708809 A neurotoxin. SGTC_1492 4158-0558 28.5 µM -0.958982207949162 0.161152501250006 no 2827 0.168783854199055 4017 3967268 SGTC_2134 5324836 1.464 µM -0.961693023670417 0.160471014277383 no 2828 0.168101913878462 4011 699272 SGTC_2332 7982454 138.89 µM -0.963663317914751 0.159976874423435 no 2829 0.167607375381717 3977 2981748 SGTC_709 3807-1509 243 µM -0.965029482011774 0.159634832185454 no 2830 0.16726502263307 4110 1886677 YPL242C IQG1 SGTC_2480 5767542 37.17 µM -0.966131268708286 0.159359330172181 no 2831 0.166989249886826 4005 2867358 SGTC_926 2268-1401 59.4 µM -0.967568294205687 0.159000469724334 no 2832 0.166630009113796 4014 2931578 SGTC_3347 9188721 44.724 µM -0.975270491236423 0.157086074317998 no 2833 0.164713051935253 4092 44118411 YKL104C | YBL026W GFA1 | LSM2 SGTC_1852 st056254 31.4 µM -0.977458143128127 0.156545105289428 no 2834 0.164171195075818 3980 442583 SGTC_2592 piperlongumine 83.33 µM -0.978665925109351 0.156246967532168 no 2835 0.163872536905606 4086 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_3044 9093193 49.47 µM -0.978731651340959 0.156230753926066 no 2836 0.16385629436251 4101 25236277 SGTC_1548 st061468 90.8 µM -0.97929524509173 0.156091769899539 no 2837 0.163717059593755 4054 390799 SGTC_1677 st019204 53.9 µM -0.982916097029111 0.15520079994486 no 2838 0.162824367343948 4087 3945625 SGTC_1147 3809-1045 12.3 µM -0.983554994386697 0.155043937911013 no 2839 0.162667181439631 4037 325925 SGTC_77 0828-0286 12.516 µM -0.985149423993854 0.154652930445977 no 2840 0.16227533964789 3984 745345 SGTC_312 4092-0653 6.84 µM -0.986748647729576 0.154261402429638 no 2841 0.161882937446207 4033 1148278 SGTC_1956 st077085 54 µM -0.992097288430028 0.152956694206282 no 2842 0.160575034577638 4123 24208685 SGTC_1268 0828-0275 2.46 µM -0.994359975179563 0.152406959545951 no 2843 0.16002382333299 4134 745337 SGTC_448 monastrol 171 µM -0.995088811918321 0.152230163425674 no 2844 0.159846535797003 3996 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity SGTC_420 mitomycin C 81.9 mM -0.995497082256623 0.152131187585265 no 2845 0.159747281323628 4068 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_323 4013-0906 34.3 µM -0.996312384815759 0.151933663958878 no 2846 0.159549194065748 4082 2910086 SGTC_1065 prochlorperazine maleate 2.48 µM -0.996687003735362 0.151842962057247 no 2847 0.159458229964101 4126 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine. SGTC_1515 3460-0031 42.1 µM -0.998684877831845 0.151359848870977 no 2848 0.158973684245044 4021 2876596 SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM -0.999047620658896 0.151272242482073 no 2849 0.158885811587543 4109 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair. SGTC_1092 toremifene 6.32 µM -1.00291963507129 0.15033921004191 no 2850 0.157949819028227 4067 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_2568 diosmetin 100 µM -1.00851963056209 0.148996586351624 no 2851 0.156602534259889 4154 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.  SGTC_608 k048-0125 159 µM -1.01372947217995 0.147754717926249 no 2852 0.155355928434298 4145 6817652 YLR060W | YFL022C FRS1 | FRS2 SGTC_222 nsc-310342 10.666 µM -1.01525259448303 0.147392964904245 no 2853 0.154992717738531 4108 432556 SGTC_1564 D-Arginine 115 µM -1.01597579652523 0.1472214069506 no 2854 0.154820456181297 4120 71070 D-isomer of arginine; arginine decarboxylase inhibitor. SGTC_225 nsc-122657 1.016 µM -1.0177580684776 0.146799188089662 no 2855 0.154396471850352 4112 275685 SGTC_3234 9132280 49.47 µM -1.02027296171878 0.146204794931856 no 2856 0.153799511438311 4142 17612295 SGTC_2892 9047358 58.44 µM -1.02195169419524 0.145808928579864 no 2857 0.153401881969807 4120 6466771 SGTC_2868 9035608 32.47 µM -1.02673384031014 0.144685190277093 no 2858 0.152272905001254 4090 6462614 SGTC_1780 st038448 24.544 µM -1.02682153320119 0.144664638272132 no 2859 0.152252253952731 4174 728868 YDL195W SEC31 SGTC_2806 7952793 58.44 µM -1.02811043608737 0.14436279344913 no 2860 0.151948941049826 4192 2972490 SGTC_3084 9116877 49.47 µM -1.02924016909077 0.144098573524371 no 2861 0.151683415349845 4058 27241325 SGTC_1512 0259-0544 12.2 µM -1.03044685370237 0.143816716668815 no 2862 0.151400144210358 4086 18476 SGTC_1402 3909-7673 35.9 µM -1.03074798361275 0.143746436909397 no 2863 0.151329508366789 4126 5328014 SGTC_1249 0481-0015 10.2 µM -1.03764709086075 0.142142622658571 no 2864 0.14971719285697 4071 4227577 SGTC_3189 9110682 49.47 µM -1.03860977239226 0.141919797644887 no 2865 0.14949312951197 4211 17122418 SGTC_32 0928-0142 34.1 µM -1.03863380800927 0.141914237320248 no 2866 0.1494875381068 4119 2244242 SGTC_2793 7325131 81.82 µM -1.04048714301129 0.141485936735162 no 2867 0.149056817133737 4098 4176441 SGTC_48 0382-0018 55 µM -1.04085787047724 0.141400367884866 no 2868 0.14897075848433 4192 762596 SGTC_2878 9043973 25.97 µM -1.04087946336352 0.141395385039479 no 2869 0.148965747052856 4183 6465167 SGTC_2418 pentamidine 31.67 µM -1.04162393860821 0.14122366026812 no 2870 0.148793032799021 4087 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_898 1000-0849 28.3 µM -1.04406266060465 0.140662121707413 no 2871 0.148228199961916 4125 6751807 SGTC_985 1493-0307 8.71 µM -1.04961235303708 0.139389907330428 no 2872 0.146948187625614 4157 3278274 SGTC_2373 9071805 200 µM -1.05124842503051 0.13901635198206 no 2873 0.146572253850002 4158 10149009 SGTC_2790 5423970 71.43 µM -1.05336620037149 0.138533824830629 no 2874 0.146086594430218 4208 1376240 YKL165C | YIL048W MCD4 | NEO1 SGTC_1353 1498-1206 8.11 µM -1.05372544815598 0.138452084924258 no 2875 0.146004317198186 4187 6756808 SGTC_707 0865-0008 204 µM -1.05541882075582 0.138067233288777 no 2876 0.145616909459269 4154 723043 SGTC_936 3005-4620 401 µM -1.05837312444282 0.137397558785204 no 2877 0.144942683555157 4218 777207 SGTC_99 0109-0120 622.8 µM -1.05881677069666 0.137297185975669 no 2878 0.144841617192655 4121 759414 SGTC_3256 9138902 49.47 µM -1.0592664535541 0.137195498529794 no 2879 0.144739224077782 4230 17228773 SGTC_1144 3486-0183 12.5 µM -1.06008308565414 0.137010963883297 no 2880 0.144553401032944 4138 6744069 SGTC_2316 5844804 197.44 µM -1.06183824773146 0.136614923486522 no 2881 0.14415456148594 4172 776813 SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM -1.06251256780611 0.136462976098624 no 2882 0.144001527801457 4120 688761 SGTC_999 SEC7.066 22.7 µM -1.06386583272254 0.136158388089892 no 2883 0.143694741552613 4119 740511 YDR170C SEC7 SGTC_3208 9114115 49.47 µM -1.06604189657891 0.135669583715305 no 2884 0.143202351555451 4181 650895 SGTC_286 k060-0067 22.9 µM -1.06611077802017 0.135654130682862 no 2885 0.143186784001516 4156 5985051 SGTC_1951 sophoraflavanone G 9.2 µM -1.06825183269738 0.135174402349285 no 2886 0.142703464779497 4120 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity. SGTC_643 k048-0106 28.4 µM -1.07491015288423 0.133689967222848 no 2887 0.141207477977685 4176 6763920 SGTC_2016 5121758 140 µM -1.07728192749416 0.133163910755584 no 2888 0.140677166835794 4080 2795203 SGTC_293 4049-0273 38.5 µM -1.07941956105437 0.13269100851839 no 2889 0.140200367359617 4039 1380311 SGTC_2049 5262831 67.185 µM -1.08175642584565 0.132175355900252 no 2890 0.139680386617583 4176 763417 SGTC_758 0868-0029 16 µM -1.08336662541914 0.13182085420272 no 2891 0.139322861661844 4199 762687 SGTC_483 fpl-64176 144 µM -1.0844147112694 0.131590460259151 no 2892 0.139090481940397 4264 3423 SGTC_1923 st058458 19.1 µM -1.08559618513423 0.131331077895091 no 2893 0.138828844156807 4198 3534982 SGTC_2719 novobiocin 32.65 µM -1.08843445119653 0.130709404613095 no 2894 0.138201679585703 4210 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication. SGTC_531 3788-1495 174 µM -1.08909558559819 0.130564887117074 no 2895 0.138055868188371 4156 2896655 SGTC_190 3970-0790 3.722 µM -1.08986871930057 0.130396027867961 no 2896 0.137885488775538 4115 2832352 SGTC_742 0kpi-0133 140 µM -1.09030693933166 0.130300383835172 no 2897 0.137788979717576 4216 2728852 SGTC_2136 5328288 199.296 µM -1.09224209766586 0.12987860487937 no 2898 0.137363351648432 4169 262395 SGTC_559 1550-0661 158 µM -1.09463965034221 0.129357356695606 no 2899 0.136837268740974 4240 5830875 SGTC_2809 7964133 12.99 µM -1.09540129756313 0.129192072006856 no 2900 0.13667043295081 4193 1253665 SGTC_3351 9150312 21.596 µM -1.09588965575229 0.129086170698028 no 2901 0.136563533241975 4109 4904905 SGTC_1776 st049249 45.9 µM -1.09743246194561 0.128752006030884 no 2902 0.136226194704431 4209 1822314 SGTC_2698 st077697 67.5 µM -1.09908887702187 0.128393902799715 no 2903 0.135864650543369 4163 3154499 SGTC_984 1492-0255 2.91 µM -1.09910450134506 0.128390528245508 no 2904 0.135861243368107 4162 1585198 SGTC_1596 piperlongumine 63 µM -1.09937355595444 0.128332427268497 no 2905 0.135802580168078 4238 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_1671 st016596 74.5 µM -1.10147828826677 0.127878550957838 no 2906 0.135344274448605 4258 2829167 SGTC_3104 9120930 49.47 µM -1.10183351001109 0.127802059094518 no 2907 0.135267029553236 4224 17014836 SGTC_1531 st059297 52.4 µM -1.10393941608549 0.127349235760332 no 2908 0.134809709571729 4207 7566702 SGTC_2179 6298986 200 µM -1.10706307582422 0.126679626828747 no 2909 0.134133329170647 4185 738374 SGTC_2499 avocadenofuran 51.48 µM -1.10739135029445 0.126609398325681 no 2910 0.134062382003519 4172 6857792 A insecticide and lysyl oxidase inhibitor. SGTC_101 0490-5701 117.494 µM -1.10769700828956 0.126544032599232 no 2911 0.133996345925653 3986 4661669 SGTC_748 act1.228 77.9 µM -1.11109123717707 0.125819747954172 no 2912 0.133264539670501 4148 4421505 YNR035C ARC35 SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM -1.11301866032075 0.125409750275055 no 2913 0.13285020765179 4234 551469 SGTC_290 2043-6722 48.1 µM -1.11369718182434 0.125265638684699 no 2914 0.13270455936617 4226 773758 YLR208W SEC13 SGTC_690 glyoxal 20.3 µM -1.11376626064377 0.125250973480104 no 2915 0.132689737397399 4009 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins. SGTC_64 000l-0018 272.079 µM -1.11383939264848 0.125235449104058 no 2916 0.132674046995357 4128 6811119 SGTC_2684 capsaicin 100 µM -1.11549814151417 0.124883692627506 no 2917 0.132318507206635 4224 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_301 4119-0100 24.5 µM -1.11921460298807 0.124098082416412 no 2918 0.131524298519883 4235 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1 SGTC_499 genistein 192 µM -1.12010113949487 0.123911192371654 no 2919 0.131335332557378 4310 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger. SGTC_1829 berberine 14.4 µM -1.12077480778167 0.123769308685831 no 2920 0.131191865035828 4186 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_2826 7992541 19.48 µM -1.12099721271217 0.12372249217104 no 2921 0.131144524426518 4223 2985066 SGTC_2051 5263410 176 µM -1.12361864878191 0.123171610815663 no 2922 0.130587420636443 4203 227584 SGTC_3313 9133968 57.047 µM -1.12498537440405 0.122885083185602 no 2923 0.130297615984515 4216 1494643 SGTC_1961 st076550 68.7 µM -1.12502913301055 0.122875917126498 no 2924 0.130288344633404 4245 1579337 SGTC_3187 9109394 49.47 µM -1.13038483815365 0.12175768267887 no 2925 0.129157050030209 4230 17098090 SGTC_2279 7948423 32.93 µM -1.13294172043656 0.121226352496726 no 2926 0.128619364113668 4213 1247112 SGTC_2439 5492030 7.2 µM -1.1345464105663 0.120893725604646 no 2927 0.128282708784208 4221 5722370 SGTC_1755 st041960 45.185 µM -1.13942403576113 0.119886615967528 no 2928 0.127263167791208 4265 2257073 SGTC_2757 clomiphene 4.22 µM -1.13995675952144 0.119776980944685 no 2929 0.127152158113333 4261 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined. SGTC_2349 9023730 187.07 µM -1.14050640333252 0.119663937880535 no 2930 0.127037693251407 4256 4126287 SGTC_3286 9117135 37.221 µM -1.14170032916158 0.119418647177491 no 2931 0.126789301979842 4210 3438150 SGTC_2458 5808907 16.39 µM -1.14254024722271 0.119246299682313 no 2932 0.126614763289155 4380 2731747 SGTC_2957 9076800 11.52 µM -1.1431388665816 0.119123572818229 no 2933 0.126490469717585 4207 16459615 SGTC_3022 9087993 49.47 µM -1.14331882267734 0.119086696282012 no 2934 0.126453121384529 4303 17173644 SGTC_2557 derrustone 83.84 µM -1.14396003920561 0.118955363953893 no 2935 0.126320104895852 4222 629853 An antioxidant. SGTC_2338 7999974 200 µM -1.14543759205909 0.118653124832442 no 2936 0.126013966789938 4234 315925 SGTC_2610 ononetin 44.17 µM -1.14635871090367 0.118464981208267 no 2937 0.125823379699522 4222 259632 SGTC_2822 7994718 71.43 µM -1.14740837957376 0.118250837738757 no 2938 0.125606439792469 4201 1018011 SGTC_104 0074-0074 590.992 µM -1.14807906740448 0.118114153748029 no 2939 0.12546796234972 4003 3943124 SGTC_1473 k844-0725 134 µM -1.14820092563109 0.118089331439124 no 2940 0.125442813628901 4286 54682906 SGTC_2465 5809242 33.21 µM -1.14893866245259 0.117939134511326 no 2941 0.125290636929958 4286 2731748 SGTC_1023 4482-3888 16 µM -1.14970633272743 0.117782986925764 no 2942 0.125132422591812 4253 3303168 SGTC_1642 st009582 77.7 µM -1.15062121111304 0.117597087686172 no 2943 0.124944051431885 4230 6739311 SGTC_2611 pyromycin 23.93 µM -1.15127092649311 0.117465194584607 no 2944 0.124810397022238 4205 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release. SGTC_1549 4'-methoxyflavonol 74.6 µM -1.15226931547983 0.117262724465369 no 2945 0.124605210949122 4185 97141 SGTC_2106 5357045 167.29 µM -1.15856503867942 0.115991665127483 no 2946 0.123316763276577 4259 668842 SGTC_1301 naphtanilide LB 4.81 µM -1.15943310367877 0.115817179530171 no 2947 0.123139844869385 4313 67238 An a1-adrenergic receptor antagonist or alpha blocker. SGTC_378 3970-0959 8.33 µM -1.16035619728164 0.115631837479364 no 2948 0.122951906456171 4276 6615653 SGTC_2676 harmalol 100 µM -1.16078983951289 0.11554484201136 no 2949 0.122863687977821 4203 5459187 A monoamine oxidase inhibitor SGTC_195 4234-0266 16.654 µM -1.16138459737513 0.115425599850535 no 2950 0.122742764966138 4256 2303354 SGTC_1862 st057513 3.81 µM -1.1620302607424 0.115296250743281 no 2951 0.122611586640469 4236 5393163 SGTC_1025 k007-0731 70 µM -1.16209102835905 0.115284082156905 no 2952 0.122599245653183 4217 6256118 SGTC_1328 1441-0025 69.2 µM -1.16494739097339 0.114713131224635 no 2953 0.122020144368505 4237 4562601 SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM -1.16529326385002 0.114644132394845 no 2954 0.121950152429464 4305 91467 include heat shock SGTC_2801 7907800 81.82 µM -1.16815907260395 0.114073562817235 no 2955 0.121371302941833 4271 6620925 SGTC_305 1682-2595 20.8 µM -1.17097275047801 0.113515343067449 no 2956 0.120804865221986 4276 226033 SGTC_461 N-acetylfarnesylcysteine 136 µM -1.17177837477765 0.113355870494557 no 2957 0.120643023533341 4314 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ). SGTC_1189 1431-2119 7.28 µM -1.17471839036724 0.112775252982096 no 2958 0.12005369967219 4252 3107275 SGTC_1809 st050081 57.6 µM -1.17525792500086 0.112668932423328 no 2959 0.119945771075741 4338 5036894 SGTC_189 3970-0742 2.116 µM -1.17595046759972 0.112532565088933 no 2960 0.119807335008314 4231 2891807 SGTC_3355 9151058 44.0485 µM -1.17692922229356 0.112340041350332 no 2961 0.119611878640735 4277 17015728 SGTC_1903 st060211 78.3 µM -1.17803781599777 0.112122262312154 no 2962 0.119390765321776 4291 688960 SGTC_1108 betulinic acid 729.144 nM -1.17931487277783 0.111871763596015 no 2963 0.119136409070223 4261 64945 Apoptosis-inducing agent of unknown mechanism. SGTC_1572 epiandrosterone 68.9 µM -1.17997900165343 0.111741650926013 no 2964 0.119004283303635 4189 441302 A steroid. SGTC_2200 6600604 21.907 µM -1.18063000615978 0.111614214607078 no 2965 0.118874869030665 4298 2904777 SGTC_2730 imipramine 71.33 µM -1.18150997752476 0.111442122577101 no 2966 0.118700096084003 4237 3696 A tricyclic antidepressant. SGTC_656 4090-1979 187 µM -1.1823001480838 0.111287754378156 no 2967 0.118543313425101 4313 22330961 SGTC_142 0335-0849 62.6745 µM -1.18632775841051 0.110503296506285 no 2968 0.117746444283178 4260 3889043 YPR107C YTH1 SGTC_647 0140-0236 81 µM -1.18745219592832 0.1102849992819 no 2969 0.11752465100142 4285 990837 SGTC_2155 5570423 76 µM -1.18805391249118 0.110168309713334 no 2970 0.117406085054163 4237 797402 SGTC_1126 isoteolin 1.0172 µM -1.18990933137313 0.10980905006005 no 2971 0.117041015228158 4215 133323 SGTC_2932 9016711 44.54 µM -1.19045658161697 0.109703248263055 no 2972 0.116933492750629 4293 7117328 SGTC_618 k072-0232 33.2 µM -1.19434602204336 0.108953397144575 no 2973 0.116171321036153 4324 5872756 YGL099W LSG1 SGTC_981 1488-1094 54.9 µM -1.1946820896054 0.108888779519614 no 2974 0.116105631360372 4248 3449522 SGTC_2448 5185112 27.17 µM -1.19616575906146 0.108603835251258 no 2975 0.115815940027387 4301 5718189 SGTC_957 1187-1561 14.1 µM -1.19651715995838 0.108536426023157 no 2976 0.115747403095383 4238 1538454 SGTC_1205 4161-2785 76 µM -1.19699996062486 0.108443859472179 no 2977 0.11565328504826 4323 3498106 SGTC_2344 7990960 76.95 µM -1.19760380537793 0.108328165309292 no 2978 0.115535646978276 4256 140813 SGTC_3057 9095946 49.47 µM -1.19796875219578 0.108258286082894 no 2979 0.115464591061819 4328 24540043 SGTC_1226 3909-7979 35.4 µM -1.19943030699428 0.107978755878786 no 2980 0.115180334475536 4290 6615510 SGTC_1969 st069479 40.1 µM -1.20139970838805 0.107602919807326 no 2981 0.114798094600274 4287 3895485 SGTC_1954 st077032 68.9 µM -1.20347048576953 0.107208754975924 no 2982 0.114397152981554 4240 698907 SGTC_3285 9112818 20.8695 µM -1.20627339164503 0.106676892029203 no 2983 0.11385604687447 4258 17017947 YPR165W RHO1 SGTC_1007 4101-0031 70 µM -1.20644885789698 0.106643660036209 no 2984 0.113822233561037 4258 1146276 SGTC_1477 0139-0234 16 µM -1.20807006845318 0.106336968317747 no 2985 0.11351015585417 4294 620880 SGTC_1075 aripiprazole 15.2 µM -1.20895993339306 0.106168899554626 no 2986 0.113339119364005 4352 60795 An atypical antipschotic. YIL048W NEO1 SGTC_2430 5571206 200 µM -1.20912245404617 0.106138225018732 no 2987 0.113307901944607 4293 1731771 SGTC_847 0342-0274 5.54 µM -1.21464018443183 0.105100591231778 no 2988 0.112251677706885 4295 18097 SGTC_186 3455-3465 67.277 µM -1.2162261974775 0.104803697368896 no 2989 0.111949383353228 4301 755278 SGTC_3295 9122362 53.5725 µM -1.2219317734283 0.103740664252567 no 2990 0.11086671436981 4306 4730473 SGTC_153 4077-0274 519.67 µM -1.22291603633014 0.103558075442719 no 2991 0.110680705488199 4353 3121976 SGTC_2390 9097792 176.6 µM -1.22993054066847 0.102263577668436 no 2992 0.109361558228234 4342 4497149 SGTC_2098 5376439 882.5 nM -1.23690304842305 0.100988534305664 no 2993 0.108061539096662 4349 2844116 SGTC_2250 alverine citrate 130 µM -1.23947652382898 0.100520870064652 no 2994 0.107584538756956 4196 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1 SGTC_714 4296-0578 26.1 µM -1.24228367846549 0.100012544450367 no 2995 0.107065957570045 4380 1589775 SGTC_1607 st000305 50.6 µM -1.24247928754438 0.0999771932203069 no 2996 0.107029888930933 4321 5457690 SGTC_1513 0337-0559 19 µM -1.24381774138422 0.0997355474705562 no 2997 0.106783324641416 4301 775073 SGTC_693 4161-2696 114 µM -1.24456522510804 0.0996007818662787 no 2998 0.106645804857891 4360 805759 SGTC_1448 4255-0083 152 µM -1.24779803407605 0.0990194632777674 no 2999 0.106052514412799 4350 5399660 SGTC_18 0111-0177 500 nM -1.25256214479388 0.0981673179545122 no 3000 0.105182549359787 4401 721752 SGTC_144 4161-2749 112.381 µM -1.25505628314503 0.0977233455775853 no 3001 0.104729164456498 4296 797501 YMR168C CEP3 SGTC_2425 5628681 7.85 µM -1.25661193639315 0.0974471759372524 no 3002 0.10444709518031 4404 5714958 SGTC_1703 st026983 48.3 µM -1.25799912376075 0.0972013966656792 no 3003 0.104196036571034 4361 1104023 SGTC_248 streptozotocin 5.23457 mM -1.26325027247314 0.0962751280243031 no 3004 0.10324962554511 4373 5300 DNA alkylating agent. SGTC_216 k038-0035 28.382 µM -1.26761272861694 0.0955105659545823 no 3005 0.102468142061211 4252 4444231 YPR107C YTH1 SGTC_430 0958-0115 16.4 µM -1.26795353639028 0.0954510248661524 no 3006 0.102407271903223 4281 6833180 SGTC_2403 6032726 181.2 µM -1.27614120730231 0.0940287932110913 no 3007 0.10095280359391 4384 2881040 SGTC_2709 st078560 56 µM -1.2790839391959 0.0935214675475778 no 3008 0.100433749349089 4347 17250903 SGTC_850 0388-0143 75.9 µM -1.2862141606042 0.0923006088544364 no 3009 0.0991841651841598 4336 67273 SGTC_2360 9040895 200 µM -1.28711849283719 0.0921466130673699 no 3010 0.0990264953517678 4372 4914414 SGTC_2781 5567276 71.43 µM -1.2888815696164 0.0918469315034614 no 3011 0.0987196311704118 4383 2853274 SGTC_2280 7785178 200 µM -1.28964881641968 0.0917167432686377 no 3012 0.0985863091189139 4347 2954328 SGTC_1636 st007707 68.9 µM -1.28983886026968 0.0916845173188779 no 3013 0.0985533061765986 4365 403051 SGTC_83 0170-0301 39.027 µM -1.29023221880194 0.0916178417234179 no 3014 0.0984850213819232 4361 3089716 SGTC_94 0334-0113 514.748 µM -1.29399373692714 0.0909820653796893 no 3015 0.0978337920872575 4365 6795178 SGTC_2514 salinomycin 42.74 µM -1.29413334878439 0.0909585311642121 no 3016 0.0978096820710393 4412 23682228 A polyether potassium ionophore. SGTC_1080 nisoldipine 24.4 µM -1.29471865079056 0.0908599166071518 no 3017 0.0977086518080151 4365 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class. SGTC_1051 3253-3903 78 µM -1.2982162861552 0.090272270709848 no 3018 0.0971065116285399 4352 5509239 SGTC_2534 helenine 20.12 µM -1.29863324876756 0.0902024045955772 no 3019 0.0970349109470056 4381 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58 SGTC_870 0573-2213 57.6 µM -1.29972908742235 0.0900189777496319 no 3020 0.0968469186682867 4369 3916321 SGTC_66 0109-0187 42.4 µM -1.30098978331895 0.0898082992932106 no 3021 0.0966309759178363 4232 759417 SGTC_1125 tnp00248 1.32998 µM -1.30192018281024 0.0896530528112851 no 3022 0.0964718361260174 4407 24207736 SGTC_1274 0865-0114 173 µM -1.30282557492959 0.0895021707087899 no 3023 0.0963171586632215 4360 870624 SGTC_455 paf C-16 10 µM -1.30301909786633 0.0894699449417752 no 3024 0.0962841208023784 4320 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis. SGTC_824 1304-0008 100 µM -1.30611375027654 0.0889557899908847 no 3025 0.0957569388016204 4394 768245 SGTC_408 cantharidin 100 µM -1.31024780211533 0.088272382095277 no 3026 0.095056009673006 4343 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_1563 conessine 56.1 µM -1.31054269690274 0.0882237824190979 no 3027 0.0950061549989559 4448 441082 An anti-amoebic, histamine inhibitor. SGTC_123 0083-0120 66.675 µM -1.31073583333578 0.088191963680173 no 3028 0.0949735139498156 4351 16001701 SGTC_2810 7959871 45.46 µM -1.31184388838287 0.0880095797145682 no 3029 0.0947864066025744 4334 2974535 SGTC_3035 9091303 49.47 µM -1.3133947687635 0.0877547799531716 no 3030 0.0945249796708814 4446 25237002 SGTC_2055 5235184 200 µM -1.31407599440976 0.0876430330269318 no 3031 0.0944103158269926 4410 2836034 SGTC_1375 2910-0797 186 µM -1.31613173997619 0.0873064561864907 no 3032 0.094064914719651 4372 742508 SGTC_620 0109-0052 432 µM -1.31876436322096 0.086876840423965 no 3033 0.0936239508012335 4421 493037 SGTC_272 doxorubicin 8.13 µM -1.32173967417427 0.0863932051554334 no 3034 0.0931274262757173 4412 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_1486 3970-0793 4.53 µM -1.32203392279033 0.0863454848052978 no 3035 0.0930784275565478 4416 2844330 SGTC_1401 3807-4679 7.6 µM -1.32413166173428 0.0860058508807574 no 3036 0.0927296609612381 4296 3291456 SGTC_3052 9092717 49.47 µM -1.32429170403058 0.0859799803692101 no 3037 0.0927030923282439 4391 25237534 SGTC_677 0929-0063 136 µM -1.32805999450057 0.0853725253579147 no 3038 0.092079144069972 4403 1539583 SGTC_1232 0279-0259 161 µM -1.33254522192126 0.084653696067674 no 3039 0.0913405458610654 4374 1560000 SGTC_1990 st072050 59.8 µM -1.33730557683037 0.0838957489953056 no 3040 0.0905614556838306 4376 17233948 SGTC_2618 avocadyne 43.43 µM -1.33853991036727 0.0837000521268251 no 3041 0.0903602496674642 4318 3015189 SGTC_1491 4138-0063 26.5 µM -1.34208374191334 0.0831401027081956 no 3042 0.0897844223807044 4395 23883227 SGTC_1932 st074806 40.9 µM -1.34262051499663 0.0830555351476605 no 3043 0.089697442024749 4445 17251235 SGTC_322 k048-0136 19.3 µM -1.34343468982943 0.0829273869860527 no 3044 0.0895656302384345 4446 6823282 SGTC_1913 st060213 96.1 µM -1.34572494131851 0.0825677074243457 no 3045 0.089195619838115 4401 688959 SGTC_311 1315-0136 58 µM -1.34980927299965 0.0819291873650782 no 3046 0.0885385848065894 4411 6759207 SGTC_2429 5902844 64.44 µM -1.35578842529448 0.0810011630280297 no 3047 0.0875832475558248 4393 1927790 YGL093W | YPR107C SPC105 | YTH1 SGTC_2135 5326629 150.42 µM -1.36142854366975 0.0801330530855813 no 3048 0.0866891504277728 4355 5020077 SGTC_1807 st050092 58.9 µM -1.36833877400606 0.0790790604646574 no 3049 0.0856030296230406 4430 5008496 SGTC_44 0929-0055 61.211 µM -1.36879043343941 0.0790105377442871 no 3050 0.0855323960643792 4291 1379590 SGTC_314 1671-0008 2.74 µM -1.37109824282855 0.0786611142618398 no 3051 0.0851721663390822 4296 3913060 SGTC_927 2425-1185 123 µM -1.37733563161337 0.0777225771916669 no 3052 0.0842042518732971 4362 730375 SGTC_2928 9011484 9.79 µM -1.38110465339546 0.0771595887177311 no 3053 0.0836233925072153 4420 2994751 SGTC_1391 3442-0225 151 µM -1.38340585507715 0.076817379030873 no 3054 0.0832702281288747 4390 5227075 SGTC_3237 9133362 49.47 µM -1.38356345446783 0.0767939848506204 no 3055 0.0832460825116104 4383 43845137 SGTC_3302 9125395 16.351 µM -1.38538930778252 0.0765233484958902 no 3056 0.0829667293214934 4372 17599668 SGTC_275 trichlorophene 5.69 µM -1.38935745125648 0.0759376746308985 no 3057 0.0823620409408889 4460 62616 SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM -1.38980084114794 0.0758724455534277 no 3058 0.0822946813112441 4450 2374 Ca(2+)-ATPase inhibitor. SGTC_2601 securinine 100 µM -1.3951092508656 0.0750948116707786 no 3059 0.0814914484806629 4396 442872 A GABA receptor antagonist. SGTC_520 3584-0023 682 µM -1.39541520974432 0.0750501774081516 no 3060 0.0814453336855151 4430 1340790 SGTC_2517 totarol 10 µM -1.39771065271866 0.0747159558882162 no 3061 0.0810999870041471 4429 460178 An antibacterial membrane disruptor. YGL001C ERG26 SGTC_3212 9128307 49.47 µM -1.39786173115987 0.0746939984367148 no 3062 0.0810772962501485 4341 27243542 SGTC_1991 st073000 8.92 µM -1.39817132882245 0.074649017490375 no 3063 0.0810308121671251 4463 4301969 YIL048W NEO1 SGTC_2925 9010536 32.5 µM -1.40269816717451 0.0739936791610236 no 3064 0.0803534320521001 4356 2994177 SGTC_845 0330-0138 4.51 µM -1.40500704929363 0.0736611256843977 no 3065 0.080009591043966 4378 9039800 SGTC_1569 carminic acid 40.6 µM -1.41027096245201 0.0729072256700758 no 3066 0.0792298446038359 4525 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_3094 9117742 49.47 µM -1.41083745665414 0.072826445428113 no 3067 0.0791462735898888 4405 17149698 SGTC_1430 4049-0248 69.1 µM -1.41214765973313 0.0726398772365769 no 3068 0.0789532440288526 4475 22774488 SGTC_701 4424-0219 185 µM -1.41290495715707 0.0725322078706971 no 3069 0.0788418356789379 4461 2911779 SGTC_3239 9133757 49.47 µM -1.42047098831083 0.0714632033376076 no 3070 0.0777353044464934 4509 17036923 SGTC_808 0711-0032 135 µM -1.42387423214177 0.0709863195217391 no 3071 0.0772414411173139 4418 4252555 SGTC_990 3985-0011 41.3 µM -1.42695577936286 0.0705566258905389 no 3072 0.0767963206315348 4421 5399565 YGL099W LSG1 SGTC_741 4582-0002 126 µM -1.42751719412277 0.0704785574754141 no 3073 0.0767154363556207 4466 2912688 SGTC_3108 9121785 49.47 µM -1.42753412648548 0.0704762039510145 no 3074 0.0767129978791301 4317 17140271 SGTC_2149 5554786 194.827 µM -1.42946904927631 0.0702076558739415 no 3075 0.0764347323108931 4483 745063 YPR165W RHO1 SGTC_3077 9117319 49.47 µM -1.42956649074376 0.070194152809555 no 3076 0.0764207393724746 4427 17154678 SGTC_2036 5160441 105 µM -1.43067829912861 0.070040224060175 no 3077 0.0762612177252064 4418 134534 YIL048W NEO1 SGTC_47 0149-0135 24.25 µM -1.43152737676283 0.0699228451107192 no 3078 0.0761395632986784 4470 5239155 SGTC_524 r073-0010 27.8 µM -1.43370230938302 0.0696228666191744 no 3079 0.0758286164497701 4392 2772106 SGTC_1392 3455-1037 33.9 µM -1.43395759255128 0.0695877216547091 no 3080 0.0757921825119364 4444 981132 SGTC_1018 4259-0013 28.1 µM -1.4356966153616 0.0693486728517707 no 3081 0.0755443443842124 4494 6801262 SGTC_157 1348-1695 65.819 µM -1.43617129570721 0.0692835325645239 no 3082 0.0754768023633614 4380 5380510 SGTC_1258 0671-0043 57.1 µM -1.43853076606605 0.0689604421722027 no 3083 0.0751417572566429 4457 4298767 SGTC_1238 0333-0287 48.8 µM -1.43961373508847 0.0688125369045538 no 3084 0.0749883557529931 4446 7226 SGTC_1880 MG-132 525 µM -1.44050659088033 0.0686907801820416 no 3085 0.0748620633412285 4420 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1 SGTC_1076 itraconazole 331 nM -1.44496800221691 0.0680848752680658 no 3086 0.0742334367986199 4464 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1 SGTC_910 3454-3003 490 µM -1.4468018553746 0.0678370192396421 no 3087 0.073976213496142 4377 820824 SGTC_897 1000-0139 31.4 µM -1.44985169133211 0.0674263599086555 no 3088 0.0735499405947632 4424 6151020 SGTC_37 0566-0070 1.56 µM -1.45277440155371 0.0670346234616688 no 3089 0.0731432007804916 4391 1626686 SGTC_2013 4024628 200 µM -1.45694745063981 0.0664783554874137 no 3090 0.072565443203816 4487 5230760 SGTC_1502 4534-4282 27.7 µM -1.4584345686414 0.0662809884214859 no 3091 0.0723603990522503 4446 3278949 SGTC_1603 st002045 67.8 µM -1.45876245189378 0.0662375335874773 no 3092 0.0723152502264936 4459 5887985 SGTC_3278 9139605 49.47 µM -1.45975072941322 0.0661066892394981 no 3093 0.0721792971007729 4459 7958859 SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM -1.46240660087374 0.0657560535554311 no 3094 0.0718149108327158 4566 16725076 SGTC_2897 9048598 12.99 µM -1.46519277474895 0.0653897662391703 no 3095 0.0714341651563582 4458 6467404 SGTC_1329 1447-1697 50.6 µM -1.46535958439513 0.0653678867454054 no 3096 0.0714114189666505 4478 2840515 SGTC_1848 st056003 16.4 µM -1.46918469804413 0.0648677244500559 no 3097 0.0708913497771666 4480 146492 SGTC_1980 st071811 45.7 µM -1.47977509593407 0.0634984469128413 no 3098 0.069466638470588 4542 4974850 SGTC_2388 9080168 200 µM -1.48307915796182 0.063075886225429 no 3099 0.0690266903765058 4501 15943073 SGTC_3190 9110366 49.47 µM -1.48416219653 0.0629378526737313 no 3100 0.0688829480600867 4495 17123768 SGTC_3213 9129884 49.47 µM -1.4854366253304 0.0627757278870416 no 3101 0.0687140998306959 4462 17190742 SGTC_1888 azatryptophan 97.5 µM -1.48873582942119 0.062357535637964 no 3102 0.0682784730687507 4508 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides SGTC_2529 gangaleoidin 93.61 µM -1.48983543387395 0.0622186384707136 no 3103 0.0681337558695664 4477 4565183 SGTC_2561 acetosyringone 100 µM -1.49068309355481 0.0621117306663383 no 3104 0.0680223584234032 4433 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent. SGTC_2047 4141938 200 µM -1.49123991810719 0.0620415813481455 no 3105 0.0679492584077993 4505 3807862 SGTC_954 1189-0853 2.85 µM -1.49160823857691 0.0619952139439256 no 3106 0.0679009385802919 4416 2828194 SGTC_2383 9036125 200 µM -1.49651220017565 0.0613804340323172 no 3107 0.0672601155218512 4443 79580 SGTC_848 0368-0089 85.6 µM -1.49831262556508 0.0611559245847696 no 3108 0.0670260226532714 4485 762535 SGTC_1122 capsaicin 818.572 nM -1.50015471270029 0.0609268847232571 no 3109 0.066787165576899 4538 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_2776 terbinafine 19.92 µM -1.50246811940849 0.0606401929460805 no 3110 0.06648812769969 4500 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_1382 3002-2117 298 µM -1.502892739204 0.0605876862174716 no 3111 0.066433352835302 4554 1497314 SGTC_2830 7992007 71.43 µM -1.50493707422449 0.0603353898625708 no 3112 0.0661701277495711 4386 1952075 SGTC_3016 9080866 49.47 µM -1.50566809334487 0.0602453728568258 no 3113 0.0660761993132595 4468 17066299 SGTC_2482 5981709 142.65 µM -1.50574252577806 0.060236213217153 no 3114 0.0660666413084406 4435 877755 SGTC_2945 9067681 61.76 µM -1.50662821043466 0.060127304690775 no 3115 0.0659529911100525 4531 16456930 SGTC_2085 5307070 144.047 µM -1.51680187804285 0.0588873245459401 no 3116 0.0646583563751379 4450 2840351 SGTC_1002 4049-0206 172 µM -1.51770248143318 0.0587785317221946 no 3117 0.064544709120386 4466 4662749 SGTC_1024 4507-0395 26 µM -1.5194386795809 0.0585692443449735 no 3118 0.0643260560421914 4536 4201836 SGTC_1613 st002381 52.1 µM -1.52050969088853 0.0584404329642427 no 3119 0.0641914625056994 4498 551167 SGTC_2037 5169046 200 µM -1.52961490870834 0.0573543076216157 no 3120 0.0630560384784159 4567 5718022 SGTC_2414 st077232 92.9 µM -1.53134142114031 0.0571501615970781 no 3121 0.0628425167405166 4449 729801 SGTC_599 1935-0052 86.5 µM -1.53340358798576 0.0569070772053667 no 3122 0.0625882226242988 4507 9557311 SGTC_1640 st009078 66.4 µM -1.53424013784149 0.0568086987054031 no 3123 0.0624852932700636 4475 690618 SGTC_640 3381-0960 37.1 µM -1.53468161594787 0.0567568347796935 no 3124 0.0624310268936585 4560 1745025 SGTC_2386 9075165 157.42 µM -1.53959706594501 0.056181894168777 no 3125 0.0618293005602428 4499 16452277 SGTC_3025 9087895 49.47 µM -1.54279782896992 0.0558099891037269 no 3126 0.0614399182072356 4501 17173641 SGTC_1370 2001-0092 44.6 µM -1.54332559996055 0.0557488529849435 no 3127 0.0613758976514945 4499 790957 SGTC_2378 9074213 121.43 µM -1.54335949108822 0.0557449288992319 no 3128 0.0613717883148301 4493 657714 SGTC_2317 5986382 200 µM -1.54369413433811 0.0557061939162116 no 3129 0.061331223989206 4525 877883 SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM -1.54584927199225 0.0554572452049858 no 3130 0.0610704871017637 4538 6710655 SGTC_2044 5102272 200 µM -1.54707477031369 0.0553160751550576 no 3131 0.0609226084531373 4519 592666 SGTC_3280 9140961 49.47 µM -1.54813696842143 0.0551939460338834 no 3132 0.0607946615580802 4542 4901226 SGTC_950 1165-0508 94.1 µM -1.54864721445307 0.055135354886215 no 3133 0.0607332747185727 4505 6148369 SGTC_1326 1431-2094 10.8 µM -1.54948178847685 0.055039627332558 no 3134 0.0606329730293944 4530 616278 SGTC_78 0336-0123 156.75 µM -1.55216639241525 0.054732587513445 no 3135 0.0603112076334225 4375 6765896 SGTC_596 1155-0152 116 µM -1.55426841685326 0.0544931241677002 no 3136 0.0600602019075146 4534 280313 SGTC_817 1391-0715 46 µM -1.55470579060558 0.0544434026970242 no 3137 0.0600080774382398 4512 1353946 SGTC_2274 7947094 46.08 µM -1.55550759279698 0.054352345513181 no 3138 0.0599126138378761 4474 2971028 SGTC_215 1287-0124 461.5 µM -1.55598131684702 0.0542986033810921 no 3139 0.0598562675673067 4554 5560863 SGTC_1421 4029-0249 71.4 µM -1.559249165169 0.0539290232959155 no 3140 0.0594687091763976 4599 2894095 SGTC_2508 celastrol 40.54 µM -1.5592628632342 0.0539274783037583 no 3141 0.0594670887709332 4448 122724 Celastrol is a natural product and antioxidant. SGTC_1785 bathophenanthroline 24 µM -1.56011575035692 0.0538313509480459 no 3142 0.0593662650804825 4452 72812 An iron chelator. SGTC_986 1493-0483 84 µM -1.56548537867327 0.0532292624930816 no 3143 0.0587345715429112 4488 40079 SGTC_1488 4013-0813 75.9 µM -1.56570221877666 0.0532050611335369 no 3144 0.0587091733067397 4516 2910057 SGTC_187 1488-2104 32.728 µM -1.56649772706992 0.0531163497505298 no 3145 0.0586160701383844 4518 2852859 SGTC_6 0844-0013 19.835 µM -1.56790577788924 0.0529596180149596 no 3146 0.0584515615874984 4627 1584900 SGTC_82 0054-0107 293.755 µM -1.56826170235834 0.0529200577913579 no 3147 0.0584100348827015 4503 3104697 SGTC_1843 st055809 45.5 µM -1.56905309487473 0.0528321802480229 no 3148 0.058317783934586 4563 16413835 SGTC_3033 9090887 49.47 µM -1.57066095246456 0.0526539976010977 no 3149 0.0581307118597671 4546 19325384 SGTC_855 0428-0020 25 µM -1.57681883446388 0.051975988368931 no 3150 0.057418608307182 4559 6812414 SGTC_1625 st003711 30.1 µM -1.57714125549553 0.0519406804334346 no 3151 0.057381513140417 4539 24207034 YER133W GLC7 SGTC_1054 3429-0080 167 µM -1.57807427228579 0.0518386142623449 no 3152 0.0572742739687606 4543 1162877 SGTC_2950 9072895 21.46 µM -1.57999959969982 0.0516284994120044 no 3153 0.0570534790740603 4480 17332245 SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM -1.5812328900038 0.0514942641168023 no 3154 0.0569123988595726 4518 5379071 SGTC_2478 5763493 32.33 µM -1.58462261281362 0.0511267452133427 no 3155 0.0565260520314193 4485 1365576 YLR208W SEC13 SGTC_1710 st031758 61.5 µM -1.59066848227611 0.0504764271181125 no 3156 0.0558421017857077 4565 5394341 SGTC_831 k061-1017 217 µM -1.59136293090805 0.0504021532919657 no 3157 0.055763960839114 4582 1240153 SGTC_2961 9083290 32.55 µM -1.59578805927577 0.0499309130042236 no 3158 0.0552680600621527 4510 17741490 SGTC_2266 7929956 200 µM -1.60417482213508 0.049047436059213 no 3159 0.0543377614480498 4496 2967153 SGTC_200 k038-0079 37.545 µM -1.60730931098979 0.0487204665158988 no 3160 0.0539932664000759 4554 3436683 SGTC_1082 camptothecin 424.86 nM -1.60873367708835 0.0485724627549624 no 3161 0.0538372942932582 4419 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_29 0299-0004 12.984 µM -1.61302659858411 0.0481285651304515 no 3162 0.0533693645966243 4467 16871 A napthoquinone isolated from Swertia calycina. SGTC_2153 5569715 200 µM -1.61379215359428 0.0480497471627578 no 3163 0.0532862585325188 4571 2054701 SGTC_2387 9077560 195.08 µM -1.61665351426367 0.0477560690334862 no 3164 0.0529765467400721 4556 5303272 SGTC_1272 0839-0021 27 µM -1.62101336622936 0.0473113573113014 no 3165 0.0525073860747994 4596 5027250 SGTC_1674 st016616 23.6 µM -1.62430074399044 0.0469782392088221 no 3166 0.0521558192748517 4521 625830 SGTC_2639 lactacystin 53 µM -1.63110559632357 0.0462946635692881 no 3167 0.0514340200204629 4567 3870 A proteasome inhibitor. SGTC_2679 rapamycin 1 nM -1.63128780667314 0.0462764701604824 no 3168 0.0514148025090499 4424 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2 SGTC_1810 st050138 53 µM -1.63281812480681 0.0461238968592263 no 3169 0.0512536269643237 4566 3444541 SGTC_921 1561-0023 372 µM -1.63457878825167 0.0459488581551706 no 3170 0.0510686886500264 4543 24050882 SGTC_1916 st067606 49.2 µM -1.63552252374682 0.0458552553695611 no 3171 0.0509697784729405 4463 19590279 SGTC_2113 5491891 107.031 µM -1.63576561210395 0.0458311699020639 no 3172 0.050944325801663 4550 789979 SGTC_1145 3546-0597 10.2 µM -1.63936951730627 0.0454752821970611 no 3173 0.0505681630397042 4548 875334 SGTC_911 3456-4043 236 µM -1.64007932069848 0.0454054513444356 no 3174 0.0504943377437543 4544 914281 SGTC_375 3970-0961 9.27 µM -1.64259234713474 0.0451589113313406 no 3175 0.0502336526060864 4541 2898222 SGTC_1064 honokiol 6.76 µM -1.64573602845953 0.0448520188110305 no 3176 0.0499090589800364 4565 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis. SGTC_137 0438-0332 85.389 µM -1.64607323656167 0.0448191998306234 no 3177 0.0498743408962167 4511 2063393 YER012W | YPR107C PRE1 | YTH1 SGTC_1013 4112-3890 241 µM -1.64631926343509 0.0447952673198505 no 3178 0.0498490227546714 4544 705171 SGTC_300 r073-0011 5.04 µM -1.647646525683 0.0446663339947039 no 3179 0.0497126135938685 4565 2735780 SGTC_1659 st012954 42.1 µM -1.67401700072583 0.0421660498970735 no 3180 0.047063629105615 4559 24207262 SGTC_1325 1431-0015 227 µM -1.67798728854813 0.0417996155927914 no 3181 0.0466747902787674 4576 1103340 SGTC_2058 5236698 133 µM -1.68025470242198 0.0415915061674258 no 3182 0.0464538851348778 4551 766665 SGTC_915 methyl methanesulfonate (MMS) 110 mM -1.68069379117773 0.0415513025814091 no 3183 0.0464112036078592 4582 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks. SGTC_574 1315-0397 40 µM -1.68088643512706 0.0415336737697018 no 3184 0.0463924876329873 4569 6794277 SGTC_2582 agaric acid 100 µM -1.68426054465162 0.0412258910343816 no 3185 0.046065663474429 4209 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase. SGTC_2510 benzyl isothiocyanate 8.31 µM -1.68481052555377 0.0411758980590086 no 3186 0.0460125667595469 4602 2346 DNA damaging agent; causes G2/M arrest. SGTC_2404 5161160 200 µM -1.68569186669387 0.0410958871181888 no 3187 0.0459275821225024 4534 2831543 SGTC_750 4073-0104 132 µM -1.68839770115059 0.0408510303129595 no 3188 0.0456674557375234 4270 22330957 SGTC_2622 2-methoxyxanthone 59.94 µM -1.68998837100845 0.0407076404453903 no 3189 0.045515089724555 4551 71034 A hepatoprotective. SGTC_2537 larixol 68.93 µM -1.69743857757878 0.0400414738878047 no 3190 0.0448068871602501 4558 6708759 SGTC_764 1951-2361 146 µM -1.69776473442844 0.0400125138923677 no 3191 0.0447760871758506 4585 5438930 SGTC_858 0438-0351 2.77 µM -1.69814765268062 0.0399785356836754 no 3192 0.0447399487984589 4575 2799119 SGTC_2018 5133068 143 µM -1.70421477213026 0.0394432929026626 no 3193 0.0441704852189315 4562 785362 SGTC_762 1165-0429 115 µM -1.70536671456379 0.039342329728739 no 3194 0.0440630260768121 4593 5967793 SGTC_3009 9080819 71.4286 µM -1.70885304384089 0.0390380474746873 no 3195 0.0437390871355915 4601 17027216 SGTC_3267 9137951 49.47 µM -1.71621994864686 0.0384013747128489 no 3196 0.043060896693312 4617 16643986 SGTC_1410 3909-8106 77.9 µM -1.71753362526456 0.0382887365405319 no 3197 0.0429408580498789 4632 1039210 SGTC_1974 st069448 26.9 µM -1.71964592355735 0.0381081873252187 no 3198 0.0427484115301397 4591 6323587 YNR016C ACC1 SGTC_2674 ligustilide 100 µM -1.72092785958044 0.0379989525419625 no 3199 0.0426319577055993 4639 5319022 A signalling regulator. SGTC_1937 st074714 47.2 µM -1.72122161318584 0.0379739575725739 no 3200 0.0426053086506387 4543 17250970 SGTC_1828 st055811 49 µM -1.72215482781859 0.037894640989627 no 3201 0.0425207376357777 4593 5877589 SGTC_1046 2001-0062 216 µM -1.72329837444379 0.0377976320637741 no 3202 0.0424172907924599 4550 739778 SGTC_1774 st048371 48.465 µM -1.72401897522998 0.0377366064906845 no 3203 0.04235220884636 4589 4242727 SGTC_1177 0983-0204 23.6 µM -1.72435334416355 0.0377083170926235 no 3204 0.0423220373546858 4635 766818 SGTC_513 4245-1575 41.7 µM -1.72519460952966 0.0376372181115591 no 3205 0.0422462034081389 4422 719745 SGTC_210 3551-0445 56.827 µM -1.72626600936123 0.0375468279581775 no 3206 0.0421497837274621 4581 2865180 YOR207C RET1 SGTC_509 pifithrin 175 µM -1.73755673855786 0.03660500520367 no 3207 0.041144474133479 4679 4817 A p53 inhibitor. SGTC_2864 9034755 47.6 µM -1.74484787115066 0.0360071457834378 no 3208 0.0405056766930588 4561 4930451 SGTC_1614 st002383 48.6 µM -1.74556611472392 0.0359486863724576 no 3209 0.0404431873184066 4640 1947235 SGTC_2833 9001315 45.46 µM -1.75362271791997 0.0352982539834819 no 3210 0.0397475878368277 4543 2989378 SGTC_2895 9054447 58.44 µM -1.7671121076312 0.0342308484733139 no 3211 0.0386047276053975 4674 2697450 SGTC_2470 5664817 21.68 µM -1.76799073237362 0.0341622540056983 no 3212 0.0385312265021497 4669 2859561 SGTC_880 0833-0487 87.2 µM -1.77100620212511 0.0339276944238996 no 3213 0.0382798351835698 4607 76075 SGTC_2653 dihydrofissinolide 100 µM -1.77236567474201 0.0338223813322185 no 3214 0.038166937921366 4693 6857746 SGTC_1091 telmisartan 47.6 µM -1.77561739944209 0.0335715734108487 no 3215 0.037898000091434 4640 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension. SGTC_1887 st057648 70.8 µM -1.77754277945845 0.0334237903736552 no 3216 0.0377394894021899 4617 688672 SGTC_2867 9039098 71.43 µM -1.77864058974301 0.0333397677072411 no 3217 0.0376493525243085 4599 6463460 SGTC_1601 4'-hydroxyflavanone 55.5 µM -1.7791392448075 0.033301659832659 no 3218 0.0376084680077333 4644 165506 SGTC_1090 efavirenz 20.7 µM -1.79120154587433 0.0323907183622333 no 3219 0.0366304791200547 4637 64139 A non-nucleoside reverse transcriptase inhibitor. SGTC_2511 berberine 10.47 µM -1.7928645612797 0.0322667559438737 no 3220 0.0364972915771736 4610 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_1883 5-benzylidenerhodanine 20 µM -1.79805826638678 0.0318821318329719 no 3221 0.0360838874061662 4611 1273210 SGTC_17 0960-0276 49.807 µM -1.80248676597302 0.0315571740185516 no 3222 0.0357344274978428 4624 6821114 SGTC_2265 7929201 200 µM -1.80445068325195 0.0314139429567592 no 3223 0.0355803418692332 4600 1265108 SGTC_2714 st079313 56.9 µM -1.80945985937809 0.03105104951932 no 3224 0.0351897954266281 4625 2939799 SGTC_315 k915-0449 187 µM -1.81394312510803 0.0307292041301771 no 3225 0.03484324121993 4656 20970215 YNL149C PGA2 SGTC_2305 7443522 69.23 µM -1.81657187156692 0.0305417792211604 no 3226 0.0346413468549548 4539 5415886 SGTC_433 pimozide 108 µM -1.81860329491285 0.0303975918209938 no 3227 0.0344859873942166 4559 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic SGTC_1187 1391-0724 117 µM -1.8188420409266 0.0303806830832141 no 3228 0.0344677661954483 4664 6997986 SGTC_124 0136-0217 7.121 µM -1.82286675282141 0.0300968115340553 no 3229 0.0341617872571007 4678 3976905 SGTC_689 0833-0039 98 µM -1.82404240503665 0.0300143064848834 no 3230 0.0340728308315435 4594 5374726 SGTC_2178 5812956 200 µM -1.82639364735089 0.0298498633229827 no 3231 0.033895494041347 4613 5403383 SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM -1.82800815605232 0.0297373797902003 no 3232 0.0337741637954256 4563 5355888 SGTC_1425 4048-4433 7.33 µM -1.83356489881723 0.029352924113646 no 3233 0.0333593033365983 4699 23734946 SGTC_1109 tnp00067 928.257 nM -1.83439563720728 0.0292958038332971 no 3234 0.0332976433839256 4629 676295 SGTC_2039 Aminomethylbenzodioxan 200 µM -1.83603596256857 0.0291832886934183 no 3235 0.0331761690364782 4655 15053 SGTC_460 trequinsin 123 µM -1.83625984849098 0.0291679595230385 no 3236 0.033159617506334 4707 5537 A vasodilator. SGTC_1981 st071826 47 µM -1.8402230794283 0.0288977077840844 no 3237 0.0328677464698605 4670 11838600 SGTC_1777 st045864 34.765 µM -1.84559584608042 0.028534666454047 no 3238 0.0324754550564615 4658 4691462 SGTC_256 clotrimazole 625 nM -1.84876797852887 0.0283221103037246 no 3239 0.0322456615042151 4590 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM -1.85132558808901 0.0281516927077572 no 3240 0.0320613635226775 4640 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding. SGTC_1111 tnp00062 510.699 nM -1.85918550083391 0.0276333092534778 no 3241 0.0315004246326221 4628 676306 SGTC_282 k297-0036 65.7 µM -1.86213240760117 0.0274410142451599 no 3242 0.0312922144981818 4636 5061378 SGTC_1802 st050112 57.9 µM -1.86355767515236 0.0273484121026636 no 3243 0.0311919230246112 4666 4662563 SGTC_1765 st044815 90.4 µM -1.86510973471492 0.0272478686383533 no 3244 0.0310830121687421 4650 645695 SGTC_2110 5483698 200 µM -1.87731862254944 0.0264676727926614 no 3245 0.0302372186791371 4639 2848765 YHR062C RPP1 SGTC_2304 7443016 91.4 µM -1.88016528135492 0.0262884688531166 no 3246 0.0300427778499841 4613 939854 SGTC_2424 5537928 59.2 µM -1.88336358125821 0.0260883393818548 no 3247 0.029825556141566 4650 5382802 SGTC_1299 1079-1439 3.74 µM -1.89039859125297 0.0256526137324279 no 3248 0.0293523358466049 4647 323161 SGTC_1602 st001878 87.6 µM -1.89324598099022 0.025477995915507 no 3249 0.0291625825994729 4630 595405 YLR310C CDC25 SGTC_949 1165-0505 146 µM -1.89540098927697 0.0253465015407012 no 3250 0.0290196488714564 4643 6244267 SGTC_901 1112-0062 60.1 µM -1.89964854540172 0.0250889882939156 no 3251 0.0287396284967062 4666 1908457 SGTC_3198 9112019 49.47 µM -1.90019177927053 0.0250562128017799 no 3252 0.0287039783553458 4683 45595555 SGTC_3316 9136639 10.545 µM -1.91011892423575 0.0244635609175089 no 3253 0.0280589514647143 4666 4903665 SGTC_1763 st044482 94.5 µM -1.93737762256789 0.0228964326507019 no 3254 0.0263495999906439 4653 88505 SGTC_3257 9139206 32.98 µM -1.94276841030054 0.0225967441307032 no 3255 0.0260220731659466 4667 4910041 SGTC_1335 1486-0900 202 µM -1.94511849025277 0.0224671356148447 no 3256 0.025880359488483 4676 X1335 SGTC_2267 7931562 200 µM -1.94882201750647 0.0222641562511013 no 3257 0.0256583417163611 4640 934880 SGTC_2117 5521686 200 µM -1.95103547938946 0.022143583259116 no 3258 0.0255264127019114 4673 803312 SGTC_1865 st057639 52.2 µM -1.95530726454802 0.0219124457380889 no 3259 0.0252734071351001 4682 688818 SGTC_2357 9067248 200 µM -1.96717102819352 0.0212811826777847 no 3260 0.0245817484344726 4630 9150235 SGTC_2942 9052777 62.25 µM -1.97278779094278 0.0209877243749982 no 3261 0.0242598723726681 4677 6469503 SGTC_429 1112-0049 25.5 µM -1.98697248616579 0.0202618268166303 no 3262 0.0234627229637172 4650 2836170 SGTC_1384 3089-0840 101 µM -1.987491321895 0.0202356841747838 no 3263 0.0234339883198355 4668 1069836 SGTC_523 1934-0222 13.7 µM -1.98939831327471 0.0201398419519354 no 3264 0.023328627840877 4661 1361595 SGTC_3290 9121031 71.43 µM -1.99572576244735 0.0198245880250947 no 3265 0.022981890640961 4688 17014854 SGTC_1989 st071868 50.2 µM -1.9988938539924 0.0196683233628653 no 3266 0.0228099199379099 4676 16414057 SGTC_2417 cerulenin 830 nM -2.01320353608897 0.0189754717356593 no 3267 0.0220466106992076 4677 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1 SGTC_2668 2',4'-dihydroxychalcone 15.08 µM -2.02445138249585 0.0184455422316227 no 3268 0.0214618647469004 4736 5357218 A potent inhibitor of glutathione S-transferases. SGTC_914 3820-6779 408 µM -2.02857226250231 0.0182545720460973 no 3269 0.0212509380647768 4624 2893481 SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM -2.03123433919616 0.0181321036245987 no 3270 0.0211156142557292 4702 6708784 An antioxidant flavonoid SGTC_597 k018-0003 82.8 µM -2.04156049003171 0.0176636560068679 no 3271 0.020597573920931 4730 6786234 SGTC_121 0557-0495 61.343 µM -2.04626837178216 0.0174535337781283 no 3272 0.0203649868503103 4689 3104427 SGTC_1868 st057644 42.7 µM -2.05344557991223 0.0171373089997554 no 3273 0.0200146912833765 4712 688665 SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM -2.06811408889378 0.0165062253381157 no 3274 0.0193146480882758 4657 521171 SGTC_993 3909-8757 62.7 µM -2.07014024281286 0.0164206374672826 no 3275 0.0192196066425112 4684 4288324 YLR208W SEC13 SGTC_1838 st055369 84.5 µM -2.072261031341 0.0163314593727129 no 3276 0.0191205522330611 4688 676036 SGTC_3006 9075424 71.4286 µM -2.07636493805961 0.0161600696003808 no 3277 0.0189301057431067 4664 7465181 SGTC_573 3702-0553 84.7 µM -2.08439439003734 0.015829192808526 no 3278 0.0185621538548158 4674 1222756 SGTC_1409 3909-8004 61.9 µM -2.10961590663693 0.0148273901903845 no 3279 0.0174457265515246 4738 2119279 SGTC_1104 tacrolimus 29.8 µM -2.13442360006508 0.0138957052688126 no 3280 0.0164040607184713 4751 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41 SGTC_1195 1502-0147 41.1 µM -2.147785186444 0.0134151376108184 no 3281 0.0158654121783016 4722 817940 SGTC_363 0455-0021 3.06 µM -2.1491920554107 0.0133653827561777 no 3282 0.0158095893993466 4643 4597466 SGTC_407 eburnamonine 100 µM -2.14972623482939 0.0133465329318986 no 3283 0.0157884380019483 4618 3195 SGTC_877 0771-0151 33.1 µM -2.1692203421007 0.0126741670680795 no 3284 0.0150329797385754 4731 6166523 SGTC_3279 9140807 49.47 µM -2.1854792224429 0.0121360042238975 no 3285 0.0144268638798213 4752 45595718 SGTC_1193 1488-0126 41.5 µM -2.18862804702426 0.012034100652434 no 3286 0.0143119427871061 4710 1384710 SGTC_3079 9117512 49.47 µM -2.1996289349356 0.0116838874159916 no 3287 0.0139166162696561 4770 7185044 SGTC_593 1203-0218 61.7 µM -2.20479577213778 0.0115224775611729 no 3288 0.0137342144334435 4752 3666956 SGTC_864 0469-0573 172 µM -2.20606223088421 0.0114832106967918 no 3289 0.0136898213765613 4713 689425 SGTC_209 4077-0173 175.592 µM -2.22962313683285 0.0107736081837714 no 3290 0.0128862362623895 4713 15993494 SGTC_1285 0929-0069 65.5 µM -2.24126691568087 0.0104372404004811 no 3291 0.0125043953255268 4744 1206237 SGTC_952 1185-0122 232 µM -2.24225188372658 0.0104092109272528 no 3292 0.0124725488019506 4696 678600 SGTC_1585 2',4'-dihydroxychalcone 10.4 µM -2.24817930992805 0.0102419142991497 no 3293 0.012282379219734 4735 5357218 A potent inhibitor of glutathione S-transferases. SGTC_2580 diallyl disulphide 81.36 µM -2.2593036263172 0.00993426187217354 no 3294 0.0119322522514608 4706 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.  SGTC_2936 9038235 15.59 µM -2.26252827174255 0.00984660350380618 no 3295 0.0118323920660743 4678 4749415 SGTC_2501 sodium tetradecyl sulfate 13.37 µM -2.268221184264 0.00969349620712366 no 3296 0.011657864451265 4724 23665772 A membrane-active detergent. SGTC_1420 4'-methoxyflavone 42 µM -2.30175098592077 0.00883325921969315 no 3297 0.010674609545469 4751 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13 SGTC_2956 9076196 2.52 µM -2.30440902111579 0.00876801902062407 no 3298 0.0105998470424378 4722 16423868 SGTC_2947 9072639 7.68 µM -2.30466625900532 0.00876172771492492 no 3299 0.0105926359827993 4683 16488146 SGTC_521 r062-0005 13.8 µM -2.30701896069817 0.00870437071397 no 3300 0.0105268815560987 4699 2832033 SGTC_1191 1487-1166 10.6 µM -2.31202924594263 0.00858332001798533 no 3301 0.0103880358434877 4735 3955771 SGTC_2441 5730946 39.09 µM -2.31242099832864 0.00857391765836045 no 3302 0.0103772471470626 4743 1774275 SGTC_201 4262-0159 12.803 µM -2.34318050147857 0.00786330556355078 no 3303 0.00956006521533795 4768 1341029 SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM -2.34598269941768 0.00780121949831201 no 3304 0.00948849415091987 4698 5711223 A potent inhibitor of glutathione S-transferases. SGTC_1287 0971-0001 34.6 µM -2.34869066102208 0.00774163157143478 no 3305 0.00941977557496821 4751 4665869 SGTC_1197 1601-0112 267 µM -2.35783157851915 0.007543436054449 no 3306 0.00919101536009647 4735 7350313 SGTC_2496 diffractaic acid 79.83 µM -2.37065717228387 0.0072728866318422 no 3307 0.00887824627941595 4728 94870 An apoptosis inducer which activates caspases. SGTC_1911 st060208 74.3 µM -2.38865809537366 0.00690760639360307 no 3308 0.00845501554153904 4746 688783 SGTC_2023 5144124 124 µM -2.3886773458545 0.00690722459071522 no 3309 0.0084545725786276 4729 2830192 SGTC_963 1269-2853 151 µM -2.39101654666863 0.00686096871956868 no 3310 0.00840089781471607 4739 3668223 SGTC_191 3914-0123 66.505 µM -2.39384352854289 0.00680543262065426 no 3311 0.0083364299264583 4777 3144412 SGTC_148 3253-0744 288.01 µM -2.39512600755142 0.00678036951214725 no 3312 0.00830732715676003 4698 6893655 SGTC_3000 9075062 71.4286 µM -2.40839227421566 0.00652585717197463 no 3313 0.0080114771182172 4743 17057871 SGTC_2408 sulbentine 18.36 µM -2.46477000012818 0.00553607140201573 no 3314 0.00685506128665039 4659 67686 An antifungal agent of unknown mechanism. YDL205C HEM3 SGTC_1955 wogonin 32.4 µM -2.46477724901575 0.00553595322510563 no 3315 0.00685492261481371 4729 5281703 A flavanone. SGTC_2624 nerol 100 µM -2.50770630812416 0.00487417635331229 no 3316 0.00607588103852852 4708 637566 A natural product oil. SGTC_1839 st053978 48 µM -2.52147873955453 0.00467733435598799 no 3317 0.0058431368593531 4785 3788398 SGTC_1417 3966-0327 90.4 µM -2.5220136581037 0.0046698342014389 no 3318 0.00583425887915653 4788 651118 SGTC_2419 paclitaxel 166.5 µM -2.5264194615016 0.00460846693539596 no 3319 0.00576159029974876 4729 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_1720 st037298 9.481 µM -2.52874769326908 0.0045763291471073 no 3320 0.00572351416604326 4747 597396 SGTC_1442 4112-3290 3 µM -2.53792506612837 0.00445158887862039 no 3321 0.00557559290164171 4781 704353 SGTC_1368 1852-0141 284 µM -2.57073958366461 0.00403004023761141 no 3322 0.00507408026714347 4730 2838987 SGTC_1775 st081588 35.1725 µM -2.5870476972401 0.00383413970364575 no 3323 0.00484010956409984 4752 1426443 YGL099W LSG1 SGTC_1463 k081-0032 34.1 µM -2.58986581215032 0.00380116572007721 no 3324 0.00480066750895995 4362 977755 SGTC_872 0588-0139 234 µM -2.59518144728248 0.00373966020137479 no 3325 0.00472704972702892 4757 2047100 SGTC_819 1013-0258 27.7 µM -2.60520275468726 0.00362612922795561 no 3326 0.00459099530907123 4766 5753198 SGTC_1864 st057645 30.4 µM -2.60651396525759 0.003611505705284 no 3327 0.0045734546936255 4794 688666 SGTC_2715 st079500 56.4 µM -2.61440428340774 0.00352461962970427 no 3328 0.00446916006450938 4768 28246688 SGTC_1740 st038286 13.222 µM -2.62221389431642 0.00344047526218585 no 3329 0.00436802918379027 4755 716786 SGTC_787 4152-0075 138 µM -2.63448291042632 0.00331192389135533 no 3330 0.00421327728083492 4763 9566539 SGTC_555 4296-0685 37 µM -2.65312645088721 0.00312483875711171 no 3331 0.00398749941434185 4783 2908540 YHR072W ERG7 SGTC_427 1354-0053 47.3 µM -2.70718659317398 0.00263493271227032 no 3332 0.00339280532781342 4765 6813657 SGTC_1870 st057514 26.5 µM -2.72190378857537 0.00251416194603877 no 3333 0.00324535181038129 4770 5393161 SGTC_1438 4092-1045 4 µM -2.75607175123318 0.00225284781179159 no 3334 0.00292500812736239 4799 1351342 SGTC_2750 bromebric acid 70.15 µM -2.83422458341306 0.00174520343627893 no 3335 0.0022968517977299 4777 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2 SGTC_783 0848-0141 92.7 µM -2.85405725633429 0.00163415147199351 no 3336 0.00215823755215817 4765 6755076 YHR007C | YLR033W ERG11 | RSC58 SGTC_752 1896-0090 130 µM -2.86691814803565 0.00156561961787847 no 3337 0.00207245099200806 4793 772567 SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM -2.90217558572819 0.00139096470233071 no 3338 0.0018529038330244 4773 364106 SGTC_1127 asiatic acid 681.4 nM -2.90820354929987 0.00136295062737514 no 3339 0.00181755822874241 4767 470603 A kinase inhibitor which arrests cells at G2/M. SGTC_2359 9039622 200 µM -2.93006710833993 0.00126561400716089 no 3340 0.00169444403998247 4773 6463596 SGTC_1264 0783-0040 158 µM -2.98531671908104 0.00104730186154135 no 3341 0.00141642422002232 4765 2855798 SGTC_2607 solasodine 47.35 µM -3.08638408225162 0.000734952055920775 yes 3342 0.00101303463419851 4756 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity. SGTC_1439 4092-1168 46 µM -3.08804320349679 0.000730629772039968 yes 3343 0.00100739588776254 4803 2886240 SGTC_1851 st056236 18.9 µM -3.14760273939795 0.000590137749476688 yes 3344 0.00082307622744544 4788 5393171 SGTC_1045 1348-1485 165 µM -3.16313757245203 0.000557842518960201 yes 3345 0.000780392780349975 4786 6810614 SGTC_1265 0819-1001 68.8 µM -3.20727363384113 0.000474789971333885 yes 3346 0.000669997358018414 4772 3106768 SGTC_1732 st034308 51.822 µM -3.23042064059964 0.000435961929406118 yes 3347 0.000618041070689066 4768 830119 SGTC_868 0527-0199 213 µM -3.36494197449278 0.000262736752680966 yes 3348 0.000382798789381484 4793 2849450 SGTC_1857 st056007 79.3 µM -3.36938669155213 0.000258297570656286 yes 3349 0.000376678290279985 4796 619834 SGTC_3074 9116018 49.47 µM -3.45458786837035 0.00018560966514783 yes 3350 0.000275567295968394 4798 17027303 SGTC_3322 9139058 2.11 µM -3.50654362094462 0.000151193343743441 yes 3351 0.000226983510866966 4805 4908926 YPR165W RHO1 SGTC_58 0957-0393 9 µM -3.59211242170826 0.000107220650335089 yes 3352 0.000164004140470913 4566 6997992 SGTC_313 3474-0040 5.03 µM -3.69418033518936 7.04800056584954e-05 yes 3353 0.000110298605494812 4803 1043375 YIL048W NEO1 SGTC_3070 9117005 49.47 µM -3.73537265998928 5.93251723718329e-05 yes 3354 9.3718704641186e-05 4804 8779016 SGTC_1253 0550-0034 176 µM -3.77904311593976 4.93286544204648e-05 yes 3355 7.87160830206741e-05 4802 5969915 SGTC_1714 st033236 13.627 µM -4.93152879585538 1.88006980012886e-07 yes 3356 4.07942686932607e-07 4810 2916566