SGTCid condition conc unit TIF4631|YGR162W.score TIF4631|YGR162W.strain.pval TIF4631|YGR162W.strain.significant TIF4631|YGR162W.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene
SGTC_2129 girgensonine 121.053 µM 9.30699232723155 9.02495600901131e-18 yes 1 6.57516929498554e-21 2 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_625 k213-0058 121 µM 7.62276687476112 1.54845682598209e-12 yes 2 1.24147534621491e-14 15 3655420
SGTC_2821 7996764 71.43 µM 6.89003184308032 1.42660502362231e-10 yes 3 2.78899502794522e-12 3 2987135
SGTC_1781 st038725 66.3 µM 6.69812130088985 4.34081761348097e-10 yes 4 1.05557998536621e-11 46 4270275 YIL048W NEO1
SGTC_832 4083-0019 164 µM 6.51589396341793 1.21473471336752e-09 yes 5 3.61290039396728e-11 14 1990758
SGTC_831 k061-1017 217 µM 5.86741422097173 3.80605396075688e-08 yes 6 2.21321937107104e-09 11 1240153
SGTC_800 3448-7362 155 µM 5.33983904451502 4.88892119195553e-07 yes 7 4.65145687521171e-08 72 15991913
SGTC_2358 9037157 4 µM 5.31386781250478 5.51178509473461e-07 yes 8 5.36612421353549e-08 9 2388925
SGTC_366 0181-0206 4.31 µM 5.15951662051269 1.11167263002473e-06 yes 9 1.23794122363832e-07 13 274874
SGTC_2674 ligustilide 100 µM 5.04157157365155 1.87598435437455e-06 yes 10 2.30862048005472e-07 2 5319022 A signalling regulator.
SGTC_118 0083-0097 135.343 µM 4.9553286428739 2.73118084334987e-06 yes 11 3.61040678165907e-07 61 5207356
SGTC_1728 st035614 33.7865 µM 4.79050767914941 5.50735191891775e-06 yes 12 8.31799280246476e-07 26 15945546
SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM 4.47825534262825 1.96023510414686e-05 yes 13 3.7627776836825e-06 15 5355888
SGTC_3133 9127736 49.47 µM 4.42995094472019 2.36923157997965e-05 yes 14 4.71272630166247e-06 13 27243420
SGTC_1942 st076330 65.2 µM 4.39842881689738 2.67844038926235e-05 yes 15 5.45186885508543e-06 19 24208414
SGTC_104 0074-0074 590.992 µM 4.3192193667309 3.63284844698683e-05 yes 16 7.82910403957658e-06 6 3943124
SGTC_3120 9124077 49.47 µM 4.30376072488646 3.85326746786502e-05 yes 17 8.39615100565673e-06 15 18774327 YGL155W CDC43
SGTC_1365 1672-3266 55.4 µM 4.24294777182293 4.84922146559158e-05 yes 18 1.10301395234646e-05 11 6415873
SGTC_582 0987-0078 156 µM 4.07187625749591 9.11500846762812e-05 yes 19 2.33179770887705e-05 63 1625765
SGTC_2688 kanamycin b 96.69 µM 3.83261640021849 0.000212012169507953 yes 20 6.33937875888722e-05 391 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis.
SGTC_309 k408-0051 1.48 µM 3.76327205302267 0.000268521002246812 yes 21 8.3852294802757e-05 59 3640463
SGTC_691 1548-0686 185 µM 3.74908304823319 0.000281692095895417 yes 22 8.87411548944261e-05 43 46495133
SGTC_1981 st071826 47 µM 3.6871326364651 0.000346557404366792 yes 23 0.000113397580331507 19 11838600
SGTC_201 4262-0159 12.803 µM 3.66811849461076 0.000369095068808877 yes 24 0.000122170972481252 54 1341029
SGTC_361 000s-0510 1.45 µM 3.65209923237613 0.000389131654851105 yes 25 0.000130052665483504 39 660
SGTC_682 0kpi-0099 17 µM 3.65129285004084 0.000390166476195895 yes 26 0.000130461754625227 81 1714895 YML126C ERG13
SGTC_3210 9128157 49.47 µM 3.64334205327462 0.000400507293170211 yes 27 0.000134560410154182 60 17590849
SGTC_2452 5863136 48.41 µM 3.62193061690648 0.000429633309094232 yes 28 0.000146206279057639 33 2184096
SGTC_2696 st077691 74.316 µM 3.61102169896828 0.000445216771703452 yes 29 0.000152496570172978 37 757133
SGTC_1040 k898-0338 155 µM 3.56217881135455 0.000521626391244699 yes 30 0.000183894867405079 30 20969351
SGTC_2578 7,8-dihydroxyflavone 64.44 µM 3.48715497226643 0.000662908732991344 yes 31 0.000244094191667733 49 1880 Intensifies effect of antibiotics on Staphylococcus aureus.
SGTC_1423 4048-0112 5.59 µM 3.44936706405362 0.00074673493859738 yes 32 0.000280951160352135 39 X1423
SGTC_679 0422-0091 41.4 µM 3.4389882252836 0.000771411099281282 yes 33 0.000291946314840003 54 627384 YHR062C RPP1
SGTC_3112 9123419 49.47 µM 3.43041059909153 0.000792369231942644 yes 34 0.000301334265547278 30 17015854
SGTC_2280 7785178 200 µM 3.41609973986581 0.000828505831965711 yes 35 0.000317624875532278 20 2954328
SGTC_2957 9076800 11.52 µM 3.37266232281313 0.000947679990644848 yes 36 0.00037222595443653 37 16459615
SGTC_2974 9094440 9.66 µM 3.34067322332338 0.00104529851377823 no 37 0.000417877633518762 66 25236134
SGTC_2017 5132927 60.65 µM 3.33833730847282 0.00105277625947423 no 38 0.000421406846719536 52 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis
SGTC_2477 5967686 25.23 µM 3.30416571690062 0.00116792307572959 no 39 0.00047629752507973 50 776118
SGTC_1389 3405-0187 19 µM 3.26771602989108 0.00130336743432494 no 40 0.000542095441257866 35 799890
SGTC_654 1124-0271 80.9 µM 3.25677071556758 0.00134675789229364 no 41 0.000563437088075144 58 5403748
SGTC_3114 9122766 49.47 µM 3.23711916335228 0.00142798904271166 no 42 0.000603714906130298 46 17176985
SGTC_2134 5324836 1.464 µM 3.22025967415601 0.00150121746913519 no 43 0.000640372636609728 38 699272
SGTC_2250 alverine citrate 130 µM 3.21401329146355 0.00152920684869946 no 44 0.000654468070376605 231 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1
SGTC_764 1951-2361 146 µM 3.2027187195069 0.00158102781413373 no 45 0.000680684392098004 66 5438930
SGTC_1232 0279-0259 161 µM 3.16454365933913 0.00176824928301565 no 46 0.000776631782320884 58 1560000
SGTC_731 3966-0296 387 µM 3.12915934802612 0.00195956946973308 no 47 0.000876536055438652 46 660956
SGTC_969 1313-0238 134 µM 3.11278060019954 0.00205433856257245 no 48 0.00092666869482462 62 5212874
SGTC_1184 1269-1718 139 µM 3.10105561693723 0.00212471451206918 no 49 0.000964160340653706 61 5403821
SGTC_165 k038-0023 64.381 µM 3.08443240588102 0.00222824035893694 no 50 0.00101970473359717 128 46368543
SGTC_56 0957-0365 83.25 µM 3.07455754662039 0.00229188219911747 no 51 0.00105407523288086 90 6752360
SGTC_2558 carylophyllene oxide 100 µM 3.03840865395464 0.00253914388946057 no 52 0.00118915597982239 51 6708694 An oxygenated terpenoid and antifungal agent.
SGTC_830 4076-0286 57.8 µM 3.02760153789507 0.0026176126776048 no 53 0.00123251442513141 138 6866659
SGTC_2835 9006588 71.43 µM 3.02450266087567 0.00264051380945174 no 54 0.00124521140487304 95 2345538
SGTC_1539 benzyladenosine 56 µM 3.02266576030955 0.00265417404243131 no 55 0.00125279408584669 43 92208 A nucleotide analog.
SGTC_3301 9125354 19.7965 µM 3.01359608785765 0.00272256138388986 no 56 0.00129085635771357 42 41905162
SGTC_2794 7785382 27.27 µM 2.99358188461109 0.00287913246226658 no 57 0.00137861755042395 97 2205081
SGTC_1272 0839-0021 27 µM 2.96690686978204 0.00310042441145909 no 58 0.00150406030152208 62 5027250
SGTC_1805 st050013 60.3 µM 2.96548010468121 0.00311268107030956 no 59 0.00151105445945672 28 4037144
SGTC_439 amiodarone 34.4 µM 2.96343001954006 0.00313036875149927 no 60 0.00152115614733474 158 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1
SGTC_1321 1326-2144 215 µM 2.93398677994346 0.00339457274133773 no 61 0.00167319230615298 41 3513030
SGTC_2497 7-hydroxyflavone 100 µM 2.91602351549421 0.00356544282240122 no 62 0.00177261889575008 60 5281894
SGTC_1197 1601-0112 267 µM 2.8958382254448 0.00376662978585377 no 63 0.00189073642449989 78 7350313
SGTC_2137 5261020 140 µM 2.89178542041011 0.00380823035938127 no 64 0.0019152973700418 90 763655
SGTC_2194 5927483 104.545 µM 2.85750016458401 0.00417696836235409 no 65 0.00213496206405781 70 760979
SGTC_1544 7-methoxy-4-methylcoumarin 105 µM 2.83848074624759 0.0043950137725119 no 66 0.0022664426992776 71 390807
SGTC_2517 totarol 10 µM 2.82672562802328 0.00453481086382299 no 67 0.00235133008600072 73 460178 An antibacterial membrane disruptor. YGL001C ERG26
SGTC_3168 9103419 49.47 µM 2.82636066264551 0.00453921403558757 no 68 0.00235401108885269 21 16649256
SGTC_2887 9044784 58.44 µM 2.81768885633492 0.00464496518950687 no 69 0.00241853293093854 116 6465546
SGTC_1772 st048439 82.2 µM 2.79182299895166 0.00497357210857097 no 70 0.00262060089494104 91 2927068 YDL195W SEC31
SGTC_188 3229-0966 278.469 µM 2.78722622499561 0.00503409100900753 no 71 0.00265806763769206 106 5722370
SGTC_3029 9088683 49.47 µM 2.78094415892763 0.00511785793718318 no 72 0.00271005296891809 80 25236615
SGTC_2662 daunorubicin 22.37 µM 2.77095726456836 0.00525358193880211 no 73 0.00279458809201026 65 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_981 1488-1094 54.9 µM 2.74984965527628 0.00555102070907311 no 74 0.00298113068685696 64 3449522
SGTC_2940 9060638 45.86 µM 2.74517884759422 0.00561882681954465 no 75 0.00302389643160476 107 4027022
SGTC_3175 9106517 49.47 µM 2.74124359180445 0.00567652477182023 no 76 0.00306035559932516 65 41468073
SGTC_708 3448-5400 146 µM 2.7390655784451 0.00570868398587651 no 77 0.0030807041077939 124 3462195
SGTC_773 4358-1457 44.6 µM 2.70660718815206 0.00620747643353008 no 78 0.00339873173358385 125 1186886
SGTC_2339 9000433 200 µM 2.70072397580973 0.00630190676933929 no 79 0.00345943666792867 109 2988954
SGTC_2943 9068529 45.32 µM 2.69407595425506 0.00641014147624268 no 80 0.00352920389107948 99 3270634
SGTC_2489 cantharidin 73.42 µM 2.69042988880965 0.00647019788381372 no 81 0.00356800139590656 138 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_2561 acetosyringone 100 µM 2.67954191846257 0.00665251285471242 no 82 0.00368614859606357 119 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent.
SGTC_1596 piperlongumine 63 µM 2.66352234939096 0.0069290102706951 no 83 0.00386636375005466 78 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_143 4032-1194 15.74 µM 2.66020459288898 0.00698752690706096 no 84 0.00390465991539335 175 1806963
SGTC_2651 TUB2.036 5 µM 2.65964920039364 0.00699736510232432 no 85 0.00391110379678899 287 15992207 YFL037W TUB2
SGTC_2985 9022375 71.43 µM 2.65503356678464 0.00707960036434402 no 86 0.00396502585642096 111 4939335
SGTC_3007 9078383 71.4286 µM 2.63568903566202 0.00743360493219782 no 87 0.00419833206854835 96 6496995
SGTC_2995 9067767 71.4286 µM 2.61754082138412 0.00777980340659377 no 88 0.00442829471188498 98 11673567
SGTC_410 α-linolenic acid 100 µM 2.61396658028282 0.00784963445532942 no 89 0.0044748895152016 98 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_2845 9003024 42.97 µM 2.60255463627639 0.00807629748536505 no 90 0.00462660349874646 154 2990173
SGTC_3278 9139605 49.47 µM 2.58639105843393 0.00840717523418688 no 91 0.00484934120770025 82 7958859
SGTC_2944 9067346 25.62 µM 2.58247243926019 0.00848916179667266 no 92 0.00490475984704293 125 6473075
SGTC_2453 5731132 22.18 µM 2.56748059311842 0.00880933808593754 no 93 0.00512202617232654 115 1362040
SGTC_33 0986-0033 35.816 µM 2.52102959673037 0.00986953675721343 no 94 0.00585060048384241 93 2848082
SGTC_2028 5153890 36.43 µM 2.5118223589306 0.0100924369876254 no 95 0.00600547661165214 112 2830968 YPR165W RHO1
SGTC_3052 9092717 49.47 µM 2.4987979891292 0.010415243910801 no 96 0.00623076621693569 133 25237534
SGTC_3013 9080133 71.4286 µM 2.49097856065888 0.0106133402310818 no 97 0.00636959033162385 119 17050193
SGTC_391 gliotoxin 8.33 µM 2.48859400805875 0.0106743995735935 no 98 0.00641246630570606 168 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion
SGTC_74 000s-0487 160.283 µM 2.48105730008945 0.0108694019288272 no 99 0.00654966568680971 119 677548
SGTC_3174 9107204 49.47 µM 2.48100223761644 0.0108708379309302 no 100 0.00655067753193807 136 3938802
SGTC_1062 mesoridazine 14.2 µM 2.47644554527054 0.0109902478743078 no 101 0.00663489329628139 108 4078 A neuroleptic.
SGTC_774 k060-0086 136 µM 2.47153484640407 0.011120210665542 no 102 0.00672672195297949 126 5911235
SGTC_2505 galangin 7.89 µM 2.46580600260565 0.0112735130326021 no 103 0.00683526757996054 70 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_146 3448-8650 53.125 µM 2.46404469858111 0.0113210127839435 no 104 0.00686894889950932 298 2891488 YIL048W NEO1
SGTC_2725 haloperidol 53.21 µM 2.44530233479125 0.011837335859217 no 105 0.00723653797297723 156 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_1382 3002-2117 298 µM 2.44236569069688 0.0119200601324517 no 106 0.0072956789276235 95 1497314
SGTC_2197 6588183 93.1375 µM 2.43986765680982 0.0119908231487746 no 107 0.00734632170921224 90 884136
SGTC_187 1488-2104 32.728 µM 2.43899655875279 0.0120155846893089 no 108 0.00736405425452486 136 2852859
SGTC_2639 lactacystin 53 µM 2.43827293299794 0.0120361879355886 no 109 0.00737881344849148 135 3870 A proteasome inhibitor.
SGTC_2967 9089538 49.85 µM 2.42816379520293 0.0123272367862995 no 110 0.00758774394438723 155 728216
SGTC_3076 9116187 49.47 µM 2.42693355704985 0.0123630689524841 no 111 0.00761352212800209 111 27241210
SGTC_2826 7992541 19.48 µM 2.42458144032322 0.0124318283830368 no 112 0.00766302267935505 130 2985066
SGTC_59 0330-0160 1.33 µM 2.42136995125216 0.012526244493116 no 113 0.00773106622942564 295 4293482
SGTC_1446 4239-0190 62 µM 2.41503024065824 0.0127144523656591 no 114 0.00786695166316215 153 1340085
SGTC_1449 4112-4002 201 µM 2.41357934711398 0.0127578677142943 no 115 0.00789834397303762 108 2059539
SGTC_237 nikkomycin 200 µM 2.41324372685446 0.0127679287863403 no 116 0.00790562130427573 128 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine.
SGTC_1393 3470-5649 58.2 µM 2.38696828406856 0.0135772062488737 no 117 0.00849397837718247 90 4108395
SGTC_15 0266-0086 27.098 µM 2.37398385291964 0.0139932127350039 no 118 0.00879866001078748 209 1712902 YIL048W NEO1
SGTC_117 lucigenin 22.078 µM 2.36779201086884 0.0141954313808254 no 119 0.00894729624835066 228 65100 An acridine derivative; a dye stuff and potential carcinogen.
SGTC_2040 5100729 123 µM 2.36308135771166 0.0143509576303906 no 120 0.00906184519505985 144 11840 YJR013W | YDR381W GPI14 | YRA1
SGTC_2730 imipramine 71.33 µM 2.36203574811369 0.0143856776386315 no 121 0.00908744476518108 174 3696 A tricyclic antidepressant.
SGTC_648 0375-0473 33.3 µM 2.3611078137244 0.0144165507321632 no 122 0.00911021631682274 144 1713139
SGTC_1073 triclabendazole 3.09 µM 2.3495917698737 0.0148044703364757 no 123 0.00939700531136163 180 50248 An antihelmetic and likely tubulin inhibitor.
SGTC_2200 6600604 21.907 µM 2.32498898970523 0.0156633865109051 no 124 0.0100362744733029 177 2904777
SGTC_2049 5262831 67.185 µM 2.32207874397772 0.0157677607337315 no 125 0.010114347997685 163 763417
SGTC_123 0083-0120 66.675 µM 2.31962957180305 0.0158560605497563 no 126 0.0101804623537641 177 16001701
SGTC_1403 3909-7815 62.9 µM 2.31858547875562 0.0158938318723117 no 127 0.0102087616149874 111 6615483
SGTC_2095 5432005 200 µM 2.31301448112844 0.0160966760056374 no 128 0.0103609214872532 114 783734
SGTC_1195 1502-0147 41.1 µM 2.30095342979727 0.0165434395409278 no 129 0.0106971317748691 166 817940
SGTC_2983 9022671 12.99 µM 2.2955475107663 0.0167471041079291 no 130 0.0108508834524613 129 6405161
SGTC_2081 5214970 32.255 µM 2.28988103523346 0.0169628836125736 no 131 0.0110141069475185 142 2063512
SGTC_174 3553-0389 74.3 µM 2.28682154883392 0.0170803739581978 no 132 0.0111031205895132 140 738071
SGTC_1841 st054148 70 µM 2.28373731510759 0.017199517940563 no 133 0.0111934868179051 133 675442
SGTC_1167 k781-0610 148 µM 2.28107003122221 0.017303127040707 no 134 0.0112721515884781 175 4525169
SGTC_2726 cimetidine 79.27 µM 2.26357714306345 0.0179959278547696 no 135 0.0118000674900032 86 2756 A P450 inhibitor, histamine H2-receptor antagonist.
SGTC_2046 4110841 106 µM 2.2627039902769 0.0180311199134792 no 136 0.0118269713437748 139 44119630 YMR134W ERG29
SGTC_3305 9127027 53.8275 µM 2.25762610033301 0.018236947032485 no 137 0.0119844900078929 160 41905295
SGTC_433 pimozide 108 µM 2.25422340012583 0.0183759895335229 no 138 0.0120910587000701 108 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic
SGTC_421 streptovitacin 30 mM 2.25179849738399 0.0184756270523554 no 139 0.0121675043472524 176 91467 include heat shock
SGTC_449 xestospongin c 11.1929 µM 2.2490882913343 0.0185875315734096 no 140 0.0122534396671614 221 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1
SGTC_747 3448-8087 38.7 µM 2.24585865874224 0.0187216362781965 no 141 0.0123565313150669 190 5168703
SGTC_2195 6536160 144.242 µM 2.24086168808379 0.0189307488070614 no 142 0.0125175177921295 128 3834386
SGTC_532 1548-0774 215 µM 2.24028149058781 0.0189551570758786 no 143 0.0125363270569042 158 5932993
SGTC_1503 4585-0012 61.3 µM 2.2360056652106 0.0191358631742672 no 144 0.0126757000324337 149 2922052
SGTC_1380 2291-0730 164 µM 2.22812840371031 0.0194726099067773 no 145 0.0129359768470711 160 2999191
SGTC_1094 duloxetine 25.4 µM 2.19828197480325 0.0207945522549745 no 146 0.0139645090509361 181 60834 A selective serotonin reuptake inhibitor.
SGTC_3292 9120825 59.784 µM 2.19271733686781 0.0210492413878007 no 147 0.0141638754288199 164 24824900
SGTC_301 4119-0100 24.5 µM 2.19088378520702 0.021133737672574 no 148 0.0142301017055166 239 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1
SGTC_1807 st050092 58.9 µM 2.18398726440148 0.0214541266720597 no 149 0.0144815919532015 165 5008496
SGTC_269 exalamide 29 µM 2.1803086188686 0.0216266968246138 no 150 0.0146172963096666 126 3316 A derivative of salicylamide.
SGTC_2713 st079149 53.4 µM 2.17902980352815 0.0216869618517563 no 151 0.0146647271283376 195 3103253
SGTC_2751 anetholtrithion 17.25 µM 2.1770443651756 0.0217808080706561 no 152 0.0147386287160676 183 2194 A chloretic substance that stimulates the liver to produce bile.
SGTC_3115 9123671 49.47 µM 2.17541153417832 0.0218582443474813 no 153 0.0147996454670523 109 3286988
SGTC_2467 5474540 200 µM 2.16799682440868 0.0222128148929465 no 154 0.015079464076965 182 5413519
SGTC_2236 dapsone 200 µM 2.16363800499224 0.0224235093541832 no 155 0.0152460711818611 163 2955 A bacterial DFR inhibitor. An anti-cancer agent.
SGTC_1271 0832-2808 169 µM 2.16131437980489 0.0225365146929986 no 156 0.015335531439538 171 3663794
SGTC_3199 9111318 49.47 µM 2.15773937629887 0.022711316079541 no 157 0.0154740503266063 187 8548020
SGTC_2022 5136654 200 µM 2.15491479219733 0.0228502322049803 no 158 0.01558425131271 174 1713771
SGTC_1460 k062-0059 9.15 µM 2.14188672725308 0.0235002668119207 no 159 0.0161012990863132 186 1373085
SGTC_961 1252-1571 372 µM 2.13703083142544 0.023746498833813 no 160 0.0162977420105846 202 6813498
SGTC_872 0588-0139 234 µM 2.136439884832 0.0237766119902636 no 161 0.016321787998746 207 2047100
SGTC_583 1488-1091 88.9 µM 2.13577042625596 0.023810764700025 no 162 0.0163490653901613 224 4303273
SGTC_2058 5236698 133 µM 2.12142153016775 0.0245527530107243 no 163 0.0169431725035118 192 766665
SGTC_2283 7944793 200 µM 2.11404610686479 0.0249416293280101 no 164 0.017255664756585 230 2970533
SGTC_1737 st035557 69.7 µM 2.1126375866632 0.0250164791935624 no 165 0.0173158995291263 158 5716916
SGTC_2645 abamectin 100 µM 2.10660238306395 0.0253393300374927 no 166 0.0175760300042511 190 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels.
SGTC_2681 menadione 3.18 µM 2.10643188529636 0.0253485012097347 no 167 0.017583427018626 180 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_26 0302-0163 425.158 µM 2.09279994843028 0.0260908225201691 no 168 0.018183508216453 154 3100915
SGTC_3116 9124943 49.47 µM 2.08509085731057 0.0265186068259549 no 169 0.0185305270050611 184 41905195 YPL160W CDC60
SGTC_752 1896-0090 130 µM 2.08499628788534 0.0265238907370099 no 170 0.018534818745475 176 772567
SGTC_3000 9075062 71.4286 µM 2.06710496122504 0.027539485641443 no 171 0.0193621323618711 192 17057871
SGTC_1622 st003707 19.4 µM 2.06174392660718 0.0278500421243943 no 172 0.0196160610549721 256 10140899
SGTC_1339 1486-1321 22.7 µM 2.05760903838571 0.0280915579932173 no 173 0.0198138391648423 215 3469382
SGTC_2818 7996756 12.99 µM 2.05541123371493 0.028220638412693 no 174 0.0199196506862094 137 2241621
SGTC_87 0100-0052 35.5 µM 2.04669850002636 0.0287372183472176 no 175 0.020343848315457 433 200187 YGR083C | YDR527W GCD2 | RBA50
SGTC_2008 4012253 172 µM 2.04660678464108 0.0287426977137403 no 176 0.0203483540822791 243 603940
SGTC_2033 5192550 145 µM 2.04301870616213 0.028957743588758 no 177 0.0205252931966857 193 182073
SGTC_1950 st077106 7.18 µM 2.04028326887252 0.0291225845899455 no 178 0.0206610601267115 220 13831864
SGTC_2396 5342950 42.78 µM 2.03253721187836 0.0295936062041024 no 179 0.0210496502881795 273 1886677
SGTC_3200 9114385 49.47 µM 2.02821088230955 0.0298594218172753 no 180 0.0212693648600091 214 17018030 YLR208W SEC13
SGTC_3336 9143619 71.43 µM 2.0234045098411 0.0301570511725858 no 181 0.0215157298062044 213 45595730
SGTC_1780 st038448 24.544 µM 2.01929068009762 0.0304137449975023 no 182 0.0217285079996105 225 728868 YDL195W SEC31
SGTC_661 1304-0007 33.6 µM 2.01800754986908 0.0304941788814998 no 183 0.021795237518404 197 3117130
SGTC_3044 9093193 49.47 µM 2.01607536390463 0.030615631660023 no 184 0.0218960478745337 250 25236277
SGTC_1584 6-fluoro-dl-tryptophan 90 µM 2.01550599129459 0.0306514974403634 no 185 0.0219258294685047 224 94937 An inhibitor of serotonin biosynthesis.
SGTC_3318 9139014 38.6185 µM 2.00844854468099 0.0310989539146938 no 186 0.0222978243610998 191 16643984
SGTC_408 cantharidin 100 µM 1.99016323280149 0.03228347007112 no 187 0.0232864785267929 244 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_1876 myriocin 605 nM 1.98662729003982 0.0325167702374636 no 188 0.0234818573552619 207 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1
SGTC_2581 avocatin a 64 µM 1.97360181872318 0.0333882134112397 no 189 0.0242135183919848 272 6710728 A skin care supplement.
SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM 1.96987099881407 0.0336413298855108 no 190 0.0244265784763163 244 6708784 An antioxidant flavonoid
SGTC_1484 3473-2379 286 µM 1.964836772422 0.0339853766999613 no 191 0.0247165663158928 238 671917
SGTC_2984 9022109 38.96 µM 1.9648036854732 0.0339876474490371 no 192 0.0247184817439174 150 6459207
SGTC_3188 9110789 49.47 µM 1.95587386755791 0.0346050755161951 no 193 0.0252400072261765 230 849217
SGTC_1721 st082152 9.2685 µM 1.95374575734064 0.0347535693939625 no 194 0.0253656460032069 221 5296051
SGTC_422 cantharidin 155 µM 1.9532592100802 0.0347875927534812 no 195 0.0253944441073993 303 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM 1.94566928545914 0.0353218922177632 no 196 0.0258472392054119 235 6312947
SGTC_2438 5259590 200 µM 1.93852414514906 0.0358310133014534 no 197 0.0262796539846509 223 1201127
SGTC_1206 3978-0017 132 µM 1.93439407564514 0.0361280299492273 no 198 0.0265323471564202 231 3873677
SGTC_88 0180-0332 8.668 µM 1.93166693483646 0.0363252569749383 no 199 0.0267003142123077 238 3101745
SGTC_3249 9135183 49.47 µM 1.92971139991294 0.0364672232629298 no 200 0.02682130333229 242 4902779
SGTC_1839 st053978 48 µM 1.92846783180544 0.0365577387127281 no 201 0.0268984808583699 235 3788398
SGTC_2679 rapamycin 1 nM 1.92825149028933 0.036573504292744 no 202 0.0269119262206281 403 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2
SGTC_3002 9075603 71.4286 µM 1.92627684762108 0.0367176608026054 no 203 0.027034907365859 246 20105405
SGTC_343 4130-2827 29.8 µM 1.91583564547001 0.0374876529690985 no 204 0.0276930095011746 262 1118244
SGTC_3238 9133470 49.47 µM 1.9137143749599 0.0376456877757732 no 205 0.0278283306430521 198 3534688
SGTC_838 0109-0203 71.4 µM 1.91207847711916 0.0377679333876675 no 206 0.0279330645030338 222 759422
SGTC_3129 9127257 49.47 µM 1.90935834660154 0.0379719174989276 no 207 0.0281079401271464 232 837894
SGTC_502 l-744,832 89.3 µM 1.90448031840093 0.0383399743987921 no 208 0.028423828774672 246 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.
SGTC_2529 gangaleoidin 93.61 µM 1.90014553976774 0.0386694778783337 no 209 0.0287070114258406 203 4565183
SGTC_3209 9113616 49.47 µM 1.89644202994484 0.0389528205170915 no 210 0.0289508093146939 259 16649353
SGTC_126 0417-1624 672.48 µM 1.89588065026879 0.038995916904266 no 211 0.0289879140667076 331 41912 YDL195W SEC31
SGTC_1534 6-azauridine 81.6 µM 1.88788357939884 0.0396140678206486 no 212 0.0295207907232576 290 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1
SGTC_1099 5-nonyloxytryptamine 2.85 µM 1.8838470755858 0.0399290911102727 no 213 0.029792831886181 247 23581825 A 5-HT1D beta serotonin receptor agonist.
SGTC_1766 st045414 44.774 µM 1.87968100392807 0.0402563584016821 no 214 0.0300757830101828 285 253960
SGTC_3194 9111903 49.47 µM 1.87805794728196 0.0403844465079231 no 215 0.0301866191574896 250 17087251
SGTC_1662 st014054 52 µM 1.8723193624997 0.0408399790499082 no 216 0.0305812167841925 191 2838777
SGTC_3324 9138759 60.749 µM 1.86632817191387 0.0413200026543564 no 217 0.0309977328180996 248 45595710
SGTC_2156 5649887 115 µM 1.86035598717657 0.0418030448410581 no 218 0.031417588643687 293 54680440 YKL052C | YBR257W ASK1 | POP4
SGTC_2444 5485484 36.41 µM 1.85861128148448 0.0419450200174848 no 219 0.0315411284284386 299 6790631
SGTC_262 fenpropimorph 62.5 µM 1.85214145669313 0.0424749123351842 no 220 0.0320027563943599 249 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_1849 st056239 19.2 µM 1.85203936602776 0.0424833169652379 no 221 0.0320100851322479 297 5393181
SGTC_2011 4012611 177 µM 1.84660787191752 0.042932408361458 no 222 0.0324019962411772 286 2049887
SGTC_1768 st044301 37.178 µM 1.84421802036112 0.0431312196397399 no 223 0.0325756865885576 267 3931349
SGTC_1627 st003713 25.6 µM 1.84308659953022 0.0432256013449716 no 224 0.0326581837733577 389 16195070 YER133W GLC7
SGTC_1769 st044406 64.4 µM 1.84230314325871 0.0432910539676621 no 225 0.0327154101305334 289 670903
SGTC_3217 9129673 49.47 µM 1.83803596265236 0.0436489551565145 no 226 0.0330285531113676 293 17248312
SGTC_1374 2889-5571 141 µM 1.82882008701509 0.0444300657738419 no 227 0.0337132823931593 314 2853281
SGTC_274 sirtinol 40.1 µM 1.82829608729167 0.0444748146996366 no 228 0.0337525633683986 263 6836442 NAD-dependent acetyltransferase inhibitor.
SGTC_825 1988-2224 89.6 µM 1.82747828671825 0.044544726406487 no 229 0.0338139439949523 301 1180859
SGTC_2064 5220758 200 µM 1.82723757943861 0.0445653207195767 no 230 0.0338320279403959 325 788518
SGTC_957 1187-1561 14.1 µM 1.82717329341705 0.044570822168422 no 231 0.0338368589903574 306 1538454
SGTC_1889 st059080 5.18 µM 1.8255438053033 0.0447104527586814 no 232 0.0339595035181933 294 176925 Isolated from Daphnopsis sellowiana.
SGTC_1294 1000-1494 117 µM 1.82035659594654 0.0451572909529384 no 233 0.0343523588728138 274 712797 YDL207W GLE1
SGTC_1730 st033808 45.1 µM 1.81483438989945 0.0456369282234663 no 234 0.0347746818675078 349 1045166
SGTC_1146 3579-1023 7 µM 1.81396382600413 0.0457129143749333 no 235 0.0348416475733286 311 X1146
SGTC_2910 7948405 25.97 µM 1.81394179937927 0.0457148382614119 no 236 0.0348433432824366 240 2971328
SGTC_2771 fluoxetine 41.05 µM 1.81316266164079 0.0457829328970212 no 237 0.0349033684253512 251 3386 A selective serotonin reuptake inhibitor.
SGTC_1038 k292-0204 154 µM 1.80706873851915 0.0463183424968437 no 238 0.0353757810977429 272 4454212
SGTC_2218 6965428 192.983 µM 1.80493984748976 0.0465065666179232 no 239 0.0355420477137347 244 675684
SGTC_2481 5478948 45.16 µM 1.80428739200043 0.0465643756726208 no 240 0.0355931326298413 298 77792
SGTC_2892 9047358 58.44 µM 1.80326642172336 0.0466549516937473 no 241 0.0356731916973402 207 6466771
SGTC_2018 5133068 143 µM 1.7968094519959 0.0472310646700045 no 242 0.0361829376530412 300 785362
SGTC_1778 st046819 58.9 µM 1.79329336723762 0.0475471715861777 no 243 0.0364630137090472 343 671715
SGTC_2302 7771753 200 µM 1.78805754139595 0.0480210269442055 no 244 0.0368833623904156 343 2203047
SGTC_1466 k213-0079 57.5 µM 1.78343396021967 0.0484426082714524 no 245 0.0372578446022613 286 3657981
SGTC_771 0250-0039 27.3 µM 1.78334746780653 0.0484505228216353 no 246 0.0372648794563446 276 3005115
SGTC_3180 9109287 49.47 µM 1.77786039966485 0.0489547382192117 no 247 0.0377133927678209 249 18891271
SGTC_1562 morin hydrate 59.1 µM 1.77643074514401 0.0490867975816822 no 248 0.0378309736620338 286 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase.
SGTC_2840 9008771 71.43 µM 1.76529929448204 0.0501247844575193 no 249 0.0387567390196127 221 2992978
SGTC_1158 4092-0494 91.8 µM 1.76447106631261 0.0502027093755258 no 250 0.0388263512559005 299 1148199
SGTC_594 1487-1584 10.8 µM 1.76008169853878 0.0506173020225871 no 251 0.0391969776805752 304 5013332
SGTC_1750 st081859 2.357 µM 1.75934351041715 0.050687293861342 no 252 0.0392595902463186 532 5291695
SGTC_2976 9009005 19.48 µM 1.75905996881832 0.0507141985428464 no 253 0.0392836616589603 285 2993148
SGTC_3250 9135583 49.47 µM 1.75595003284648 0.0510100410343243 no 254 0.0395484703942352 246 7699353
SGTC_2595 hexamethylquercetagetin 100 µM 1.75528579650583 0.051073406296177 no 255 0.0396052173717206 279 386331
SGTC_3296 9122258 64.045 µM 1.75388671857485 0.051207077180857 no 256 0.0397249599007926 320 4730474
SGTC_632 0781-2353 4.65 µM 1.75173685640028 0.0514130219259539 no 257 0.0399095331314615 335 6811515 YHR007C ERG11
SGTC_388 3',4'-dichloroisocoumarin 16.7 µM 1.7467008355434 0.0518980236532913 no 258 0.0403446226912933 282 1609 A potent and irreversible inhibitor of serine proteases.
SGTC_2172 5754775 163.918 µM 1.74470797402385 0.0520909503990963 no 259 0.0405178572844192 305 2263357
SGTC_620 0109-0052 432 µM 1.74430156021222 0.0521303647278076 no 260 0.0405532598722705 296 493037
SGTC_1069 diphenylcyclopropenone 8.49 µM 1.74062432451772 0.0524880636366132 no 261 0.0408747255046322 376 65057 A dermal irritant. YDR527W RBA50
SGTC_750 4073-0104 132 µM 1.73680427818982 0.0528617147076059 no 262 0.0412108618324758 237 22330957
SGTC_2038 4100038 30.985 µM 1.73550962654295 0.0529888264255291 no 263 0.0413252889469197 334 3596803
SGTC_3306 9127676 59.7925 µM 1.73205936792214 0.0533287643280792 no 264 0.041631496328548 313 41905287
SGTC_2855 9016525 58.44 µM 1.73114969878808 0.0534186771150409 no 265 0.0417125340991883 318 43811474
SGTC_2241 6772625 37.8075 µM 1.7225799065208 0.0542716338607973 no 266 0.0424822606172658 313 2285411
SGTC_2819 7996655 46.38 µM 1.7223116415406 0.0542985073788451 no 267 0.0425065399861974 274 6456960
SGTC_1255 0566-0045 221 µM 1.71763321379111 0.0547688650220147 no 268 0.0429317690758952 339 2788469
SGTC_2933 9026794 32.47 µM 1.71552035700501 0.0549823395098514 no 269 0.0431249331855318 355 17586027
SGTC_91 0417-1751 58.384 µM 1.71137697099173 0.0554028789773686 no 270 0.043505772789546 417 6795624
SGTC_992 3909-8734 162 µM 1.70958133808023 0.0555859165902456 no 271 0.0436716595006545 309 4288319
SGTC_1952 st077036 64.1 µM 1.7074177015281 0.0558071003185068 no 272 0.0438722212568946 341 2937007
SGTC_2447 5741742 33.78 µM 1.70613501150886 0.0559385543702332 no 273 0.0439914726201465 349 1776504
SGTC_518 1021-0119 62.6 µM 1.69954921127063 0.0566173381905104 no 274 0.0446078752703403 355 1097762
SGTC_2471 5466956 24.79 µM 1.69838739223286 0.0567377549133475 no 275 0.0447173350441817 272 724419
SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM 1.69138543983287 0.0574677490447597 no 276 0.0453816056557717 360 5379071
SGTC_2254 7938975 95.19 µM 1.68810754019488 0.057812018508804 no 277 0.045695293648793 401 2969277
SGTC_416 estradiol valerate 100 µM 1.67735494211968 0.0589527292471086 no 278 0.0467365473635144 326 13791 A steroid.
SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM 1.67128180685628 0.0596047703883453 no 279 0.0473330141129037 352 5393153
SGTC_362 0310-0100 9.03 µM 1.66568990675214 0.0602101288552604 no 280 0.0478875966711581 355 790235
SGTC_2350 9023895 38.85 µM 1.66533045218919 0.0602492061130379 no 281 0.0479234231472958 335 2997209
SGTC_2290 7904846 200 µM 1.6652661148255 0.0602562024924422 no 282 0.0479298378511146 348 2962154
SGTC_2859 9028643 45.46 µM 1.66130586755251 0.0606880860051241 no 283 0.0483260160954386 300 17151580
SGTC_396 dithiazanine 1.25 µM 1.6575791675287 0.0610967076967045 no 284 0.048701218698939 283 10578 An antihelmenthic.
SGTC_666 0272-0154 136 µM 1.65131996003253 0.0617878464540401 no 285 0.0493366293478519 390 6870312
SGTC_429 1112-0049 25.5 µM 1.64682400597179 0.0622880428629943 no 286 0.049797112784158 340 2836170
SGTC_2906 7926292 26.41 µM 1.64533673220145 0.0624542025541075 no 287 0.0499501944239205 357 2966319
SGTC_2234 tolnaftate 200 µM 1.63901711628279 0.0631640931488214 no 288 0.0506048475245335 252 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7
SGTC_3202 9113761 49.47 µM 1.63753056388569 0.0633319889064061 no 289 0.0507598290508479 438 4798415
SGTC_2359 9039622 200 µM 1.63698292345837 0.0633939285820914 no 290 0.050817018852089 354 6463596
SGTC_697 0508-1955 564 µM 1.63558465272185 0.0635522908447835 no 291 0.0509632722690678 385 6243113
SGTC_1421 4029-0249 71.4 µM 1.63518537090812 0.0635975682823182 no 292 0.0510050969608293 369 2894095
SGTC_934 2950-0684 338 µM 1.63086347539192 0.064089266769809 no 293 0.0514595650692253 375 1121253
SGTC_1190 1486-1332 13 µM 1.62863797528693 0.0643436102419203 no 294 0.0516948400664195 336 4150046
SGTC_1029 k015-0030 64.7 µM 1.62541368573868 0.0647134919003081 no 295 0.0520372208649311 357 2208316
SGTC_3140 9094243 49.47 µM 1.62460531844973 0.0648064839731857 no 296 0.0521233415899611 369 19291112
SGTC_2070 5230947 200 µM 1.62399580018958 0.064876669654448 no 297 0.052188352444337 356 2835538
SGTC_306 1672-3436 11.6 µM 1.62319982284598 0.0649684148284239 no 298 0.0522733478586547 357 6797378
SGTC_312 4092-0653 6.84 µM 1.61548000307895 0.0658634417957153 no 299 0.053103393687503 471 1148278
SGTC_508 roscovitine 141 µM 1.6121504008426 0.0662524092360118 no 300 0.0534646076881114 308 160355 A CDKinase inhibitor.
SGTC_2377 9073351 62.6 µM 1.60944664592623 0.0665695715146703 no 301 0.0537593562931386 355 7337946 YHR072W ERG7
SGTC_2503 beta-caryophyllene alcohol 24.72 µM 1.60889273639832 0.0666346923368399 no 302 0.0538198990176479 301 61125 An anti-inflammatory.
SGTC_795 0685-0265 78 µM 1.60643315192072 0.0669244510665237 no 303 0.0540893858415665 388 302754
SGTC_535 2293-4129 48.2 µM 1.60357556556999 0.0672623205594179 no 304 0.0544038201321735 457 396118 YIL048W NEO1
SGTC_1682 st012968 530 nM 1.59885118463221 0.0678238027051071 no 305 0.0549268364153566 327 24207270
SGTC_1719 st032227 49.2 µM 1.59453106102267 0.0683404020661605 no 306 0.0554085697411645 378 3125804
SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM 1.59280241650462 0.0685479614816284 no 307 0.0556022614346703 367 6708760
SGTC_3139 9095020 49.47 µM 1.59019933454211 0.0688614321299058 no 308 0.0558949402380144 254 25236292
SGTC_3321 9137793 26.8275 µM 1.58828463421472 0.0690927104196394 no 309 0.0561109952498661 412 4904192
SGTC_2630 antimycin a 100 µM 1.58825305069189 0.0690965304326511 no 310 0.0561145646518287 420 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain.
SGTC_1761 st044296 37 µM 1.58778622866426 0.0691530113316371 no 311 0.0561673432821746 380 1826700
SGTC_744 1594-0068 283 µM 1.58730880957699 0.0692108111596944 no 312 0.0562213604875192 434 668392
SGTC_711 k292-0785 179 µM 1.58384748434762 0.0696309781494568 no 313 0.0566142152575007 372 4146315
SGTC_1448 4255-0083 152 µM 1.58351448579083 0.0696715038588294 no 314 0.0566521238157727 370 5399660
SGTC_14 0354-0009 295 µM 1.58332990596275 0.0696939749251821 no 315 0.0566731449975659 378 1713507
SGTC_956 1185-0240 191 µM 1.58170845577576 0.0698916129071596 no 316 0.0568580707409944 368 1416193
SGTC_899 1083-0020 478 µM 1.57947784668962 0.0701642054798647 no 317 0.0571132469653834 405 767123
SGTC_1076 itraconazole 331 nM 1.57506565374934 0.0707058071367218 no 318 0.0576206454683685 380 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1
SGTC_1726 st035556 14.5795 µM 1.57137188133156 0.0711616875876716 no 319 0.0580481467174989 417 5919439
SGTC_3319 9138450 16.7555 µM 1.56933800072527 0.0714136680792796 no 320 0.0582846010932589 361 2029690
SGTC_946 3434-1334 87.4 µM 1.56924331406007 0.0714254156119907 no 321 0.0582956275557299 386 4047976
SGTC_2151 5563267 85.4165 µM 1.56814649665843 0.0715616030610513 no 322 0.058423473717626 403 5310824
SGTC_2980 9014342 25.29 µM 1.56701470662165 0.0717023417066159 no 323 0.0585556270470399 375 2996599
SGTC_2488 5268135 45.7 µM 1.56317139969793 0.0721818437985046 no 324 0.0590061426356786 480 1270356 YLR208W SEC13
SGTC_1483 3453-0561 55.9 µM 1.55819674201328 0.0728061412491265 no 325 0.059593308535343 425 4546991
SGTC_2507 purpurin 79.67 µM 1.55579721055149 0.0731087458658902 no 326 0.0598781608322407 417 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1
SGTC_1372 2752-0194 270 µM 1.55242795205071 0.0735352658791031 no 327 0.0602799297726306 363 823334
SGTC_1181 1222-0449 220 µM 1.54969451235367 0.0738826924189949 no 328 0.0606074279496819 392 658318
SGTC_853 0419-0306 21 µM 1.5495008754134 0.0739073516216009 no 329 0.0606306806188031 369 762713
SGTC_2242 6630449 61.2675 µM 1.54708952031519 0.0742149589871042 no 330 0.0609208303038993 353 691249 YDR170C SEC7
SGTC_2941 9056145 11.23 µM 1.54574800084052 0.0743865143031541 no 331 0.0610827198464305 310 2119517
SGTC_2324 6149169 200 µM 1.5444059464447 0.0745584408284745 no 332 0.0612450101929916 350 2888231
SGTC_479 n-linoleoylglycine 10 µM 1.53831566196865 0.0753424620681088 no 333 0.0619857260554508 340 6433346 An anti-infammatory.
SGTC_970 1315-0089 19.5 µM 1.5353761599972 0.0757231146439311 no 334 0.0623457281064237 376 6811083 YLR033W RSC58
SGTC_279 1273-0055 2.93 µM 1.5330012394164 0.0760317249189444 no 335 0.0626377747646736 436 2847562
SGTC_2513 baicalein 25.65 µM 1.52851120129587 0.076617800455414 no 336 0.0631928322928992 395 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2
SGTC_2598 perillyl alcohol 100 µM 1.52737676490616 0.0767664184462914 no 337 0.0633336753730986 418 10819 An apoptosis inducer.
SGTC_852 0418-0143 439 µM 1.52662507133333 0.0768650155005698 no 338 0.063427134514848 494 5369229
SGTC_93 0109-0045 59.227 µM 1.52660704536334 0.0768673810863578 no 339 0.0634293770268501 518 88733
SGTC_726 3448-4391 34.2 µM 1.52557806781023 0.077002507737685 no 340 0.0635574888115945 433 1356692
SGTC_2567 aureobasidin a 60 nM 1.52146181422782 0.0775448655970424 no 341 0.064071993464166 460 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1
SGTC_1773 st048542 73.5835 µM 1.52052722258891 0.0776684105571036 no 342 0.0641892611267241 440 3237138
SGTC_2333 9017922 200 µM 1.51547532382256 0.0783388163023951 no 343 0.0648260373945865 409 3163164
SGTC_2608 thymoquinone 42.66 µM 1.51183839780547 0.078824159979432 no 344 0.0652874892540394 355 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC).
SGTC_3346 9158254 43.5805 µM 1.51066363917826 0.0789814159886189 no 345 0.0654370854597012 429 17639500
SGTC_3177 9107506 49.47 µM 1.50969099428987 0.07911179629426 no 346 0.0655611451475205 338 8897194
SGTC_432 NS 1619 61.3 µM 1.50104203446019 0.0802783421351307 no 347 0.0666723449165681 394 4552 A K+/calcium channel activator.
SGTC_459 nigericin 15.3 µM 1.50004093868165 0.0804142020065431 no 348 0.0668018991520409 462 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification.
SGTC_1860 st056228 74.6 µM 1.49718484228275 0.0808027609379972 no 349 0.0671725841606163 395 688679
SGTC_541 4513-1321 94 µM 1.48367660095307 0.0826597229198433 no 350 0.0689473683870173 434 747515
SGTC_2972 9093619 59.92 µM 1.48328624171035 0.0827138586731382 no 351 0.0689991880857312 433 25236256
SGTC_1771 st048882 4.1505 µM 1.48066186138236 0.0830785055283549 no 352 0.0693483509059495 412 4580403
SGTC_1806 st050005 60.3 µM 1.47913010729929 0.0832918944736772 no 353 0.0695527724671585 427 5194765
SGTC_2700 st077718 96.8 µM 1.4781316866415 0.0834312062968637 no 354 0.0696862671355137 379 904970
SGTC_2747 doxorubicin 7.63 µM 1.47730730531628 0.0835463659700079 no 355 0.0697966403235219 255 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_704 1310-0270 142 µM 1.4735699701762 0.0840699412616564 no 356 0.0702987058650174 467 5718033
SGTC_607 4491-0986 66.8 µM 1.47017882776475 0.0845471455252104 no 357 0.0707566636652565 473 698981 YDR232W HEM1
SGTC_1695 st026914 34.495 µM 1.46322234325741 0.0855324224838471 no 358 0.0717032744499359 439 3289191
SGTC_1852 st056254 31.4 µM 1.46188394723691 0.0857229676416157 no 359 0.0718865073234684 426 442583
SGTC_386 1509-0011 3.07 µM 1.45887737003769 0.0861521673643262 no 360 0.0722994313524952 556 3107280
SGTC_1651 st011928 86.1 µM 1.45854552742512 0.086199637421965 no 361 0.0723451178467932 442 720198
SGTC_2520 obtusaquinone 4.71 µM 1.45826581742605 0.0862396651070454 no 362 0.0723836441522503 435 5967872
SGTC_2424 5537928 59.2 µM 1.45740436552252 0.0863630298616897 no 363 0.0725023963737709 487 5382802
SGTC_2808 7946468 45.46 µM 1.45510012210808 0.0866936589835107 no 364 0.0728207726942277 495 2970879
SGTC_2811 7967822 32.47 µM 1.45399252923691 0.0868529204678258 no 365 0.0729741887227749 462 2232244
SGTC_31 0508-1974 57.237 µM 1.45064313563528 0.0873358618706426 no 366 0.073439628648923 455 6810525
SGTC_2071 5230951 39.92 µM 1.44920306869593 0.0875441169851474 no 367 0.0736404404061621 471 1799272
SGTC_1301 naphtanilide LB 4.81 µM 1.4385865516751 0.0890908725675853 no 368 0.0751338494386213 484 67238 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_492 tmb-8 126 µM 1.43767086024296 0.0892252295260433 no 369 0.0752637324145785 287 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1
SGTC_275 trichlorophene 5.69 µM 1.4367016100425 0.0893676092089366 no 370 0.0754013986476428 642 62616
SGTC_1871 st057448 67.3 µM 1.43669480416501 0.0893686095672708 no 371 0.07540236598998 480 691747
SGTC_1276 0871-0068 94.2 µM 1.42982969874455 0.0903819207072175 no 372 0.0763829515178081 428 3414906
SGTC_2531 methyl deoxycholate 70.07 µM 1.42901389313845 0.0905029010936598 no 373 0.0765001201571739 445 16667744 Haematoxylin.
SGTC_2769 toremifene 3.73 µM 1.42639864597193 0.0908915412065297 no 374 0.076876652164866 428 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_817 1391-0715 46 µM 1.42553837339464 0.0910196526985959 no 375 0.0770008179553618 431 1353946
SGTC_2235 salicylic acid 500 µM 1.42194479921864 0.091556255035508 no 376 0.0775211382356169 421 338 A COX inhibitor and kinase inhibitor.
SGTC_751 0833-0568 350 µM 1.41747359360962 0.0922271763225663 no 377 0.0781722547306316 467 6954252
SGTC_1022 4477-0945 21.3 µM 1.41681847754465 0.0923257838465663 no 378 0.0782680029910667 479 4648966
SGTC_1873 rapamycin 2 nM 1.41145473426796 0.0931360662085633 no 379 0.0790552868577464 531 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1
SGTC_1474 0330-0125 5.35 µM 1.41131771097697 0.0931568344736602 no 380 0.079075477249824 459 X1474
SGTC_2755 lomerizine 42.69 µM 1.41071827267557 0.0932477300193817 no 381 0.0791638504402045 495 3949 A calcium channel blocker.
SGTC_1638 st008370 60.6 µM 1.40732086285028 0.0937641331529042 no 382 0.0796661328213028 502 24207134
SGTC_1803 st050068 52.4 µM 1.40730114726739 0.0937671360520163 no 383 0.0796690546470211 687 3984059 YIL048W | YNL267W NEO1 | PIK1
SGTC_3091 9116372 49.47 µM 1.40590169359514 0.0939804695811653 no 384 0.0798766591774659 440 17169793
SGTC_3148 9097893 49.47 µM 1.40177859673424 0.0946110787013474 no 385 0.0804906858716556 468 17174100
SGTC_2932 9016711 44.54 µM 1.40149433536188 0.0946546698579729 no 386 0.0805331501502431 526 7117328
SGTC_527 4476-4215 268 µM 1.39627427167397 0.0954577944868051 no 387 0.0813159591931435 496 4418754
SGTC_2475 5812728 15.03 µM 1.39614844635225 0.0954772148588154 no 388 0.0813348987558175 507 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2
SGTC_2663 amphotericin b 100 µM 1.39356157361824 0.0958771276094956 no 389 0.0817250195686188 455 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_163 TUB2.036 7.546 µM 1.39109607933551 0.0962594214643764 no 390 0.0820981468173022 662 15992207 YJR013W GPI14
SGTC_581 0958-0271 211 µM 1.38886352071469 0.0966065624301211 no 391 0.0824371275630141 592 4591145
SGTC_1846 st056244 14.8 µM 1.38854927158869 0.0966554988243592 no 392 0.0824849260893625 515 5393182
SGTC_1529 apigenin 74 µM 1.38719741004795 0.0968662248923655 no 393 0.0826907874988519 524 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_578 3460-0051 92 µM 1.38522135561131 0.0971748557979576 no 394 0.0829923962999429 543 2876744
SGTC_1844 rapamycin 4 nM 1.38457497454523 0.0972759675658569 no 395 0.0830912340121481 636 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2
SGTC_1583 clindamycin 39.6 µM 1.38394771830243 0.0973741614660158 no 396 0.0831872319664675 471 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis.
SGTC_1862 st057513 3.81 µM 1.38347730256349 0.0974478504523461 no 397 0.0832592810911857 464 5393163
SGTC_2732 terfenadine 20 µM 1.37886650164827 0.0981722826002117 no 398 0.0839679590570608 414 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.
SGTC_3031 9088762 49.47 µM 1.37661516852529 0.0985274339134057 no 399 0.0843156293410969 501 205253
SGTC_640 3381-0960 37.1 µM 1.37510707652441 0.0987658632977103 no 400 0.0845491253985571 512 1745025
SGTC_1576 erythromycin ethylsuccinate 23.2 µM 1.37480485783163 0.0988136948252168 no 401 0.084595975839383 514 3256 An antibiotic and ribosome inhibitor.
SGTC_3234 9132280 49.47 µM 1.37334842626297 0.099044438923549 no 402 0.0848220273345549 520 17612295
SGTC_254 nsc-64875 3.808 µM 1.37034679856096 0.099521232862211 no 403 0.0852893354657368 481 56993
SGTC_176 1486-1328 72.834 µM 1.3700632288333 0.0995663631071053 no 404 0.0853335825123409 537 22310231
SGTC_1124 fisetin 1.16336 µM 1.36713571331266 0.100033152921118 no 405 0.0857913854935744 456 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster.
SGTC_575 k072-0246 11.9 µM 1.3663820735316 0.100153578354717 no 406 0.0859095362092381 517 6796779
SGTC_1816 st051957 91.6 µM 1.36338827383293 0.100633008212975 no 407 0.0863800873662782 475 674121
SGTC_462 ag-879 158 µM 1.3583544438371 0.101442900464043 no 408 0.0871756211716269 539 6809654 Ag-879 is a 5-Lipoxygenase inhibitor.
SGTC_1200 1643-0193 18.4 µM 1.3579711474866 0.101504762923213 no 409 0.0872364197759372 543 5403974
SGTC_1910 st062352 60.4 µM 1.35371362254988 0.102193758325616 no 410 0.0879138801638941 511 2245730
SGTC_72 0744-0168 198.391 µM 1.35315443848886 0.102284503254891 no 411 0.0880031486322392 498 677577
SGTC_115 0527-0192 112.043 µM 1.34930761617187 0.102910358048956 no 412 0.0886190901655921 610 4233931
SGTC_1416 3966-0321 25.3 µM 1.34311280669921 0.10392405610085 no 413 0.0896177246572686 533 582530 YLR208W SEC13
SGTC_2310 7668677 200 µM 1.34011171016215 0.104417741283674 no 414 0.0901045147719738 511 2197143
SGTC_198 3454-2873 16.191 µM 1.33997797116188 0.104439781047734 no 415 0.0901262534163017 512 710957
SGTC_1675 st018485 24.5 µM 1.33898875638096 0.104602905191906 no 416 0.0902871666238542 520 3323024
SGTC_2402 5553605 200 µM 1.33801983150203 0.104762862317542 no 417 0.0904449860820245 536 6758546
SGTC_2361 9034121 116 µM 1.33779793884441 0.10479951887649 no 418 0.0904811569888401 506 6496917
SGTC_71 0417-1750 47.813 µM 1.33298321417842 0.105597197459946 no 419 0.0912686561988003 558 6811472
SGTC_2099 5377090 177.372 µM 1.33294798248858 0.1056030505995 no 420 0.0912744373843897 544 2243829
SGTC_2469 5655019 90.81 µM 1.33196486688724 0.105766472972939 no 421 0.0914358668254854 543 2788239
SGTC_1541 2',3',6-trimethoxyflavone 64 µM 1.33167945545489 0.105813950867875 no 422 0.0914827715354675 555 688801
SGTC_3255 9139072 49.47 µM 1.32702077106811 0.106591097141212 no 423 0.0922509058953142 527 17646060
SGTC_356 1634-0012 32.5 µM 1.32626930064928 0.106716839851013 no 424 0.0923752558498562 562 735457
SGTC_3160 9100216 49.47 µM 1.3251213571823 0.106909130567972 no 425 0.0925654517865802 524 17191039
SGTC_1874 staurosporine 7.6 µM 1.32464060625449 0.106989734833223 no 426 0.0926451905616749 539 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1
SGTC_2724 maprotiline 69.64 µM 1.32415078739361 0.107071904533041 no 427 0.092726485612931 518 4011 A tricyclic antidepressant.
SGTC_1575 cyproterone acetate 48 µM 1.32283718201283 0.10729249345434 no 428 0.0929447646415083 525 9880 An androgen receptor antagonist and liver toxin.
SGTC_3245 9134821 49.47 µM 1.32231341670873 0.10738053873702 no 429 0.093031903459417 551 17014901
SGTC_2238 6671620 73.2395 µM 1.31905703420009 0.10792910735271 no 430 0.0935750229008497 509 729941
SGTC_1457 k015-0032 57.3 µM 1.3186476517848 0.107998214265184 no 431 0.0936434675543491 535 4302660
SGTC_1843 st055809 45.5 µM 1.3168898064354 0.108295314262305 no 432 0.09393778191637 507 16413835
SGTC_1899 st063254 59.6 µM 1.31671464892215 0.108324950480575 no 433 0.0939671457291722 463 3093813
SGTC_2920 7982904 15.77 µM 1.31647004351023 0.108366346877342 no 434 0.0940081632828736 459 6456808
SGTC_147 4466-0538 29.23 µM 1.31414697871697 0.108760063973704 no 435 0.0943983736574553 570 6742687 YHR072W ERG7
SGTC_246 cycloheximide 667 µM 1.30884777930302 0.109662028558865 no 436 0.095292959312528 468 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells.
SGTC_1605 st000082 49.1 µM 1.30606057105823 0.110138582314006 no 437 0.0957659800505251 529 1114022
SGTC_2319 6033012 152.6 µM 1.30487039323333 0.110342529563781 no 438 0.0959684921131845 478 847246
SGTC_595 3909-8003 73.7 µM 1.30476432546828 0.11036071832535 no 439 0.095986555110152 536 699517
SGTC_2800 7887935 81.82 µM 1.30403925236479 0.110485113229124 no 440 0.0961100996763481 526 2961002
SGTC_1623 st003709 20.3 µM 1.30249255147929 0.110750803978054 no 441 0.0963740312849916 621 16192618
SGTC_1757 st041620 31.8375 µM 1.30154400910937 0.110913969957558 no 442 0.0965361553945942 557 5289815
SGTC_2010 4012422 159 µM 1.2990055688213 0.111351473226489 no 443 0.0969710090283819 556 952393
SGTC_482 fipronil 114 µM 1.29628283282675 0.111822111647358 no 444 0.0974390304072205 467 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels.
SGTC_2369 9071472 200 µM 1.29365021247557 0.11227852432387 no 445 0.0978931349651331 553 17296037
SGTC_717 1532-0246 73.2 µM 1.28985546275309 0.112938753365335 no 446 0.0985504233798851 572 9561992
SGTC_681 1642-0006 26.6 µM 1.28832227391189 0.113206289497679 no 447 0.0988169013380875 498 4446530
SGTC_2678 equilin 100 µM 1.28642016212462 0.113538829445496 no 448 0.099148232794862 567 3247 Equilin is an estrone commonly used hormone replacement therapy
SGTC_89 0302-0250 142.109 µM 1.28547461925813 0.113704394521471 no 449 0.0993132402028482 607 4203518 YLR208W SEC13
SGTC_2831 7999036 19.48 µM 1.28435332631686 0.113900956494503 no 450 0.099509178000999 582 2988270
SGTC_1716 st033144 30.6155 µM 1.28288844646014 0.114158113666466 no 451 0.0997655805698041 583 674617
SGTC_2123 5259487 200 µM 1.28256742935939 0.114214522869899 no 452 0.0998218336266374 596 2173474
SGTC_2094 5332512 191.667 µM 1.28222295644194 0.114275075811554 no 453 0.0998822227026506 580 755774
SGTC_2856 9022925 19.48 µM 1.28143560194797 0.114413566228039 no 454 0.100020352930049 578 4944862
SGTC_3065 9113888 49.47 µM 1.27839543453597 0.114949432747963 no 455 0.100555016500207 509 16648368
SGTC_579 4491-1009 110 µM 1.27270029324308 0.115958069749146 no 456 0.10156220677118 713 1271041
SGTC_2734 clemastine 41.6 µM 1.26608090800837 0.117138271369082 no 457 0.102742058568661 400 26987 Clemastine is a selective histamine H1 antagonist.
SGTC_2618 avocadyne 43.43 µM 1.26340084923712 0.117618523916198 no 458 0.103222579555258 546 3015189
SGTC_840 0245-0196 390 µM 1.26315977925748 0.11766179062221 no 459 0.103265882045961 633 3827528
SGTC_1479 0549-0158 134 µM 1.2598316233974 0.118260272264358 no 460 0.103865054626653 651 5440202
SGTC_3285 9112818 20.8695 µM 1.25688147016721 0.118792576851949 no 461 0.104398279624233 620 17017947 YPR165W RHO1
SGTC_1427 4048-4900 550 nM 1.2529261078193 0.119508906676452 no 462 0.105116299733036 578 24132586
SGTC_1740 st038286 13.222 µM 1.24804903198811 0.12039635016134 no 463 0.106006550824849 592 716786
SGTC_1163 k060-0048 49.9 µM 1.24745894659676 0.120504037354029 no 464 0.106114632125043 623 6809982
SGTC_3107 9121808 49.47 µM 1.24566611547527 0.12083163477706 no 465 0.106443499235827 479 662681
SGTC_3192 9110362 49.47 µM 1.2448847123534 0.120974613641544 no 466 0.106587065576168 603 16649480
SGTC_2215 7188065 200 µM 1.24351158719369 0.121226152384677 no 467 0.106839686881712 518 940217
SGTC_402 epigallocatechin gallate 10 µM 1.24174433345115 0.121550431425041 no 468 0.10716545358024 617 65064 An antioxidant.
SGTC_1275 0867-0008 21.1 µM 1.24119818701137 0.121650768797022 no 469 0.107266272211556 587 3422836
SGTC_1045 1348-1485 165 µM 1.240648942672 0.121751734000413 no 470 0.107367731663639 638 6810614
SGTC_2889 9059656 51.95 µM 1.23667442323677 0.122484107397915 no 471 0.108103988896644 630 3949838
SGTC_1109 tnp00067 928.257 nM 1.23337333291402 0.123094735605527 no 472 0.108718254743214 612 676295
SGTC_2862 9027634 71.43 µM 1.23033530594222 0.123658585602434 no 473 0.109285784223081 559 5012562
SGTC_1432 4049-0298 68.4 µM 1.22967195401 0.123781942192229 no 474 0.109409986646123 570 741646
SGTC_2939 9044578 71.43 µM 1.229149134741 0.123879226084496 no 475 0.109507947913302 580 2653634
SGTC_974 1326-0144 138 µM 1.22728529964733 0.12422647566852 no 476 0.109857689408472 617 5411856
SGTC_3124 9127567 49.47 µM 1.22353674241768 0.124926926663226 no 477 0.11056351769058 566 17592030
SGTC_2166 5933061 31.504 µM 1.22335055806605 0.124961788633627 no 478 0.110598659501136 600 2877375
SGTC_1663 st014140 55.4 µM 1.22202730925991 0.125209755310031 no 479 0.110848649921147 690 4207120
SGTC_308 4092-1169 104 µM 1.22180819164395 0.125250849404792 no 480 0.110890085032354 643 2268590 YDL196W YDL196W
SGTC_2785 7756463 72.73 µM 1.21727590035236 0.12610296378021 no 481 0.111749630202454 583 2201551
SGTC_1869 3',7'-dimethoxyflavone 40.3 µM 1.21408489818712 0.126705321977514 no 482 0.112357653109783 623 688664
SGTC_1949 st076024 69.1 µM 1.20675745413631 0.128096081419131 no 483 0.113762782728075 589 2921930
SGTC_868 0527-0199 213 µM 1.2065186706923 0.128141580569045 no 484 0.113808782241108 636 2849450
SGTC_3330 9141424 71.43 µM 1.20583912363016 0.128271126736936 no 485 0.113939763493406 659 27261020
SGTC_3023 9089636 49.47 µM 1.20442500448515 0.128541000282132 no 486 0.114212676193031 656 17249241
SGTC_418 lividomycin a 100 µM 1.20019430755934 0.129350747676602 no 487 0.115031942802148 668 72394 An antibiotic.
SGTC_885 0865-0106 16.8 µM 1.19974071895664 0.129437773037991 no 488 0.115120026817587 615 2793380
SGTC_1521 st012942 49.4 µM 1.19829290577974 0.129715821378849 no 489 0.115401503719323 674 24207259
SGTC_2265 7929201 200 µM 1.19686139213512 0.129991145865324 no 490 0.115680292279646 609 1265108
SGTC_598 3937-0236 20.2 µM 1.19505375301839 0.130339388491583 no 491 0.116033014623154 686 1379313
SGTC_1194 1488-0194 225 µM 1.19437171748541 0.130470950533429 no 492 0.116166297527942 660 1391452
SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM 1.19300779216602 0.130734321907414 no 493 0.116433160675243 617 4330530
SGTC_705 1124-0212 310 µM 1.19123852165651 0.131076511908149 no 494 0.116779980466051 645 9554485
SGTC_1865 st057639 52.2 µM 1.18881000384488 0.131547211983072 no 495 0.117257220267165 629 688818
SGTC_2576 guaiol 23.12 µM 1.18773803989708 0.131755352843763 no 496 0.117468315974791 663 227829
SGTC_2314 7727897 200 µM 1.18696291724766 0.131905998173677 no 497 0.117621123965674 602 900724
SGTC_511 blebbistatin 171 µM 1.18689989512318 0.131918251763947 no 498 0.117633554355073 616 3476986 A myosin inhibitor.
SGTC_1587 estradiol valerate 56.1 µM 1.18401752480408 0.132479519397579 no 499 0.118203062846264 657 13791 A steroid.
SGTC_1669 st015249 58.4 µM 1.18224917199454 0.13282467400402 no 500 0.118553423490136 625 722793
SGTC_2145 5634607 200 µM 1.18212296828594 0.132849330631669 no 501 0.118578456036962 560 308662
SGTC_1867 st057372 64 µM 1.18100716163293 0.133067464743076 no 502 0.118799939153642 625 688837
SGTC_1281 0884-0031 11.8 µM 1.18076796891757 0.133114257684072 no 503 0.118847455952764 654 1548255
SGTC_663 1486-0733 13.9 µM 1.17977269020452 0.133309084279362 no 504 0.119045317052721 701 722445 YPR165W RHO1
SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM 1.17798844963183 0.133658841680656 no 505 0.11940060549522 690 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_1637 st007924 17.4 µM 1.17650289346669 0.133950530140878 no 506 0.119696988430886 638 683336
SGTC_2774 tamoxifen 10.92 µM 1.17645341720812 0.133960252309094 no 507 0.119706868346508 626 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.
SGTC_1520 flindersine 88 µM 1.17576783977254 0.134095019343735 no 508 0.119843830525764 655 68230 Flindersine is a natural alkaloid of the quinoline subtype.
SGTC_1362 1611-0397 101 µM 1.17275021645433 0.134689314188368 no 509 0.120447993688123 641 27816
SGTC_1668 st014914 51.6 µM 1.17244109272345 0.134750295341812 no 510 0.120510004751086 627 2839556
SGTC_1471 k673-0312 37 µM 1.17238707061104 0.134760954283383 no 511 0.120520844041449 614 24099884
SGTC_2919 7978188 46.38 µM 1.16701274849721 0.135824238211892 no 512 0.12160261061213 657 2980291
SGTC_2159 5658611 73.75 µM 1.16619976024118 0.135985582965298 no 513 0.121766844747533 637 793844
SGTC_2065 5221596 34.26 µM 1.1649563354213 0.136232605406046 no 514 0.122018333986202 628 788581
SGTC_47 0149-0135 24.25 µM 1.16388807630524 0.136445073992232 no 515 0.122234686168842 611 5239155
SGTC_2569 tetrandrine 100 µM 1.15998604377549 0.137223083913999 no 516 0.123027244162339 576 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_141 0443-0274 32.331 µM 1.15774022610673 0.137672239365486 no 517 0.123485031435753 760 1627241
SGTC_1812 st052057 4.327 µM 1.157044269885 0.137811631517594 no 518 0.123627136947808 680 3645418
SGTC_1930 st074634 34.3 µM 1.15626026336502 0.137968774450993 no 519 0.123787358343063 660 684253 YOR116C RPO31
SGTC_2371 9071574 200 µM 1.15075287924125 0.139076095562059 no 520 0.124916957610585 590 45596039
SGTC_782 0083-0095 30.5 µM 1.15018934524463 0.139189740583544 no 521 0.125032946829207 700 3591729 An indicator and reagent.
SGTC_921 1561-0023 372 µM 1.14784345650774 0.13966350298507 no 522 0.125516596970535 668 24050882
SGTC_1135 dihydrocapsaicin 536.708 nM 1.14604664437246 0.140027117690711 no 523 0.125887926308657 644 107982 A Capsaicinoid.
SGTC_528 3492-0019 172 µM 1.1441561989793 0.140410374463156 no 524 0.126279432221448 856 2869262
SGTC_227 fluconazole 33.516 µM 1.14373031296368 0.140496814073016 no 525 0.126367749001505 701 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C
SGTC_2431 5490079 200 µM 1.14070307228267 0.141112276476695 no 526 0.126996753817923 683 5722345
SGTC_954 1189-0853 2.85 µM 1.14050272901747 0.141153072276936 no 527 0.127038458199629 689 2828194
SGTC_2830 7992007 71.43 µM 1.14041483791242 0.141170972022758 no 528 0.127056757026532 628 1952075
SGTC_614 0462-0418 107 µM 1.14023985448997 0.141206613416799 no 529 0.127093193834788 610 5188303
SGTC_2653 dihydrofissinolide 100 µM 1.13878823576515 0.141502520735363 no 530 0.127395744858951 649 6857746
SGTC_988 1497-1057 103 µM 1.13856959747781 0.141547125755801 no 531 0.127441357520256 687 3533044
SGTC_1513 0337-0559 19 µM 1.13843427959526 0.141574737115108 no 532 0.127469593437568 600 775073
SGTC_860 0443-0016 25.1 µM 1.13711289926112 0.141844554084572 no 533 0.127745546088034 682 5337942
SGTC_1665 st014639 11.4 µM 1.13618128879929 0.142034991833424 no 534 0.127940349895605 721 981133 YIL048W NEO1
SGTC_314 1671-0008 2.74 µM 1.13568038496127 0.142137457002256 no 535 0.128045176351242 711 3913060
SGTC_2248 tofa 1.1 µM 1.13472500195176 0.142333029363095 no 536 0.128245279147805 629 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_729 4092-0585 94.1 µM 1.1341978006442 0.14244102839736 no 537 0.128355793190709 625 2169061
SGTC_42 0133-0086 60.653 µM 1.13397678888635 0.142486319915134 no 538 0.128402142221185 602 162923 Model of phenazepam hydroxylation.
SGTC_478 N-arachidonylglycine 10 µM 1.13366477650224 0.142550276597767 no 539 0.128467595040285 545 5283389
SGTC_3322 9139058 2.11 µM 1.13268741960036 0.142750742058686 no 540 0.128672771283485 696 4908926 YPR165W RHO1
SGTC_2326 6164455 177.58 µM 1.1323174740085 0.142826671215186 no 541 0.128750493140525 613 2888790
SGTC_3156 9099931 49.47 µM 1.13158410556328 0.142977271457731 no 542 0.128904662757806 710 18111053
SGTC_1008 4106-0037 6 µM 1.13126361490632 0.143043119220257 no 543 0.128972076886246 666 2905394
SGTC_3008 9078912 71.4286 µM 1.12900510184316 0.143507732488955 no 544 0.129447840742487 660 16648731
SGTC_3272 9137413 49.47 µM 1.12882182631329 0.14354547991632 no 545 0.129486501664033 649 17614870
SGTC_2321 7390090 138.78 µM 1.1272195258217 0.1438757751349 no 546 0.129824838466359 601 649046
SGTC_725 1497-0963 19 µM 1.12472744758039 0.144390505533827 no 547 0.130352273482774 707 3549977
SGTC_2780 5215298 71.43 µM 1.12390277046559 0.144561112785888 no 548 0.130527137945619 724 2834131
SGTC_2978 9011784 42.97 µM 1.12060867363785 0.145243942034274 no 549 0.131227235673638 801 2994934
SGTC_1304 1165-0502 251 µM 1.11873407588267 0.145633492429709 no 550 0.13162680164845 729 767425
SGTC_3075 9116269 49.47 µM 1.11414036056442 0.146591055977381 no 551 0.132609488067777 690 17015205 YNL244C SUI1
SGTC_167 3672-0051 66.205 µM 1.11335991431212 0.146754159583494 no 552 0.132776941896356 631 3237971
SGTC_647 0140-0236 81 µM 1.11140975781851 0.147162250209165 no 553 0.133196007045115 788 990837
SGTC_1456 k015-0012 13 µM 1.10982623853474 0.147494177327143 no 554 0.133536955179145 777 2989616
SGTC_1506 4226-2149 212 µM 1.10977990065806 0.147503897922269 no 555 0.133546941235322 744 991114
SGTC_3263 9137018 49.47 µM 1.10690557041838 0.148107703788009 no 556 0.134167378628203 652 43844957
SGTC_914 3820-6779 408 µM 1.10573863646329 0.148353311108388 no 557 0.134419830902497 669 2893481
SGTC_1705 st027868 56.3335 µM 1.10451612867299 0.148610907223293 no 558 0.134684655525917 684 292948
SGTC_2044 5102272 200 µM 1.10295059595686 0.148941218954396 no 559 0.135024310139973 642 592666
SGTC_791 1348-1292 225 µM 1.0981340152988 0.149960543375492 no 560 0.136072987021763 797 5437054
SGTC_2110 5483698 200 µM 1.0947682601239 0.150675586870697 no 561 0.136809087516316 693 2848765 YHR062C RPP1
SGTC_192 3455-0609 60.9 µM 1.09439071463849 0.150755936543461 no 562 0.136891827287327 697 3769639
SGTC_2269 7935389 174.42 µM 1.09406324910758 0.150825651240513 no 563 0.136963619637308 681 97605
SGTC_3246 9135460 32.98 µM 1.09155392690556 0.151360577399674 no 564 0.137514608264903 626 41446951
SGTC_839 0122-0028 230 µM 1.08852768423983 0.152007374738029 no 565 0.138181110934093 758 759448
SGTC_2399 5884133 200 µM 1.08791368820244 0.152138827495805 no 566 0.138316606350582 689 722445
SGTC_1549 4'-methoxyflavonol 74.6 µM 1.08763413510573 0.152198703087819 no 567 0.138378327562982 723 97141
SGTC_3277 9138724 49.47 µM 1.08727874250053 0.152274844818313 no 568 0.138456820121406 617 15943418
SGTC_3049 9092223 49.47 µM 1.08496669135884 0.152770811699124 no 569 0.138968204020481 679 8623917
SGTC_1399 3562-5772 25 µM 1.08274132126401 0.153249195070963 no 570 0.13946162872109 626 23847490
SGTC_1894 3',6'-dihydroxyflavone 78.7 µM 1.08119649014804 0.153581867411353 no 571 0.139804859484513 698 688662
SGTC_933 2914-0560 114 µM 1.08114187634587 0.15359363699003 no 572 0.139817004085446 786 463887
SGTC_3081 9117243 49.47 µM 1.07689467453515 0.154510761957841 no 573 0.140763661262789 715 45595589
SGTC_1246 0422-0085 105 µM 1.07469297756064 0.154987609916776 no 574 0.141256104408885 758 264295
SGTC_1868 st057644 42.7 µM 1.0724945179349 0.155464725424368 no 575 0.141748987473235 770 688665
SGTC_445 e6 berbamine 66 µM 1.06885177459476 0.156257414093199 no 576 0.142568232646805 841 6610268 A calcium/calmodulin antagonist.
SGTC_1360 1598-0022 39.8 µM 1.06844925980167 0.156345167447117 no 577 0.142658953419109 812 761525
SGTC_2555 cholic acid 100 µM 1.06807615334213 0.156426538392792 no 578 0.142743080847645 727 6708657 Influences liver metabolism.
SGTC_3224 9130643 49.47 µM 1.06760509657492 0.156529311188523 no 579 0.142849341842087 689 17644395
SGTC_766 1391-0721 126 µM 1.06672211170304 0.156722076130558 no 580 0.143048669593137 744 1020919 YIL115C NUP159
SGTC_2416 tofa 880 nM 1.06637180088077 0.156798595961216 no 581 0.143127801889278 657 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_855 0428-0020 25 µM 1.06522263473589 0.157049785623378 no 582 0.143387596532839 678 6812414
SGTC_559 1550-0661 158 µM 1.06288211798376 0.157562203866528 no 583 0.143917706667056 740 5830875
SGTC_1156 4092-0367 4.88 µM 1.05732136911312 0.158784040543726 no 584 0.145182471954116 744 1357585
SGTC_1743 st037606 46.3785 µM 1.05556708286401 0.15917078679173 no 585 0.145583023169875 734 590142 YLR208W | YDL195W SEC13 | SEC31
SGTC_1602 st001878 87.6 µM 1.05509427180061 0.159275127192044 no 586 0.145691105787659 749 595405 YLR310C CDC25
SGTC_501 nsc-95397 161 µM 1.05427915988652 0.159455112023043 no 587 0.145877563572242 732 262093
SGTC_2773 thioridazine 9.09 µM 1.05414576860983 0.159484578818423 no 588 0.145908092242368 766 5452 An antipsychotic.
SGTC_2178 5812956 200 µM 1.05000893316281 0.160400195658527 no 589 0.146857002810937 734 5403383
SGTC_1752 st044819 83.042 µM 1.04981278354343 0.160443695103816 no 590 0.146902098325849 710 441209 YML126C ERG13
SGTC_78 0336-0123 156.75 µM 1.0456868333435 0.161360479321775 no 591 0.147852821878763 697 6765896
SGTC_2790 5423970 71.43 µM 1.04514614954784 0.161480871710883 no 592 0.147977713742699 791 1376240 YKL165C | YIL048W MCD4 | NEO1
SGTC_2370 9071495 200 µM 1.04245383829404 0.162081232036469 no 593 0.148600658340052 715 21791103
SGTC_881 0833-0569 170 µM 1.04227543956803 0.162121064577283 no 594 0.148641997925468 750 5418700
SGTC_2881 9058953 51.95 µM 1.04199470631301 0.162183759091949 no 595 0.148707066627111 803 17122249
SGTC_929 2805-0021 398 µM 1.03953767677204 0.162733146730041 no 596 0.14927737245131 739 3098024
SGTC_2676 harmalol 100 µM 1.03924388880336 0.16279891814734 no 597 0.149345661757256 796 5459187 A monoamine oxidase inhibitor
SGTC_94 0334-0113 514.748 µM 1.03664138448036 0.163382305322776 no 598 0.149951509370844 769 6795178
SGTC_989 1501-0895 10.3 µM 1.0360882096871 0.163506481854419 no 599 0.150080496097488 778 2830112
SGTC_1975 st070967 30.8 µM 1.03362379500154 0.164060437564938 no 600 0.150656035458427 840 261391
SGTC_297 0986-0032 24 µM 1.03062296978282 0.164736610493134 no 601 0.151358830116791 729 2847425
SGTC_199 4063-0024 41.6 µM 1.03053956941113 0.164755428764386 no 602 0.151378393612312 794 306215
SGTC_2749 bexarotene 57.39 µM 1.02939229858833 0.165014437687798 no 603 0.151647683314749 736 82146 An retinoic acid receptor inhibitor.
SGTC_2652 actinonin 100 µM 1.02829538049282 0.165262325334077 no 604 0.151905451697874 759 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase.
SGTC_1153 4055-0057 267 µM 1.02733170516982 0.165480300789407 no 605 0.152132148979318 784 882706
SGTC_1863 st057641 20.1 µM 1.02659452308851 0.165647170820784 no 606 0.152305717033956 816 3921635
SGTC_1259 0671-0132 43 µM 1.02561885409712 0.165868192483705 no 607 0.152535638404074 755 X1259
SGTC_1608 st001473 40.5 µM 1.02361518561161 0.166322687815271 no 608 0.153008534871015 741 7292267
SGTC_3017 9080681 49.47 µM 1.02237389483721 0.166604654845755 no 609 0.153301985561327 761 16451914
SGTC_1982 st072467 71.9 µM 1.02066990230084 0.166992229652939 no 610 0.153705429404911 821 3163533
SGTC_3088 9117578 49.47 µM 1.0181901434727 0.167557291208005 no 611 0.154293801333047 786 678341
SGTC_1402 3909-7673 35.9 µM 1.01793837457087 0.167614730472372 no 612 0.154353621668428 760 5328014
SGTC_1355 1499-0035 1.68 µM 1.01698416939528 0.167832540626316 no 613 0.154580480166184 761 1548538
SGTC_2614 arthonioic acid 13.39 µM 1.01657385098765 0.167926257318459 no 614 0.154678099459523 724 6710684
SGTC_2963 9082507 9 µM 1.01645168150119 0.167954167326234 no 615 0.154707172801723 711 16459611
SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM 1.01574624017655 0.168115386033477 no 616 0.154875121156099 751 364106
SGTC_3226 9131256 49.47 µM 1.01462655445811 0.16837147886046 no 617 0.155141938167831 695 17178073
SGTC_2606 farnesol 9.78 µM 1.01096938716158 0.169209687592723 no 618 0.156015540941828 789 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_142 0335-0849 62.6745 µM 1.01031921598956 0.169358984342435 no 619 0.156171188807558 898 3889043 YPR107C YTH1
SGTC_3344 9148862 3.898 µM 1.00767521464406 0.169966988694999 no 620 0.156805203730333 805 4905352
SGTC_1353 1498-1206 8.11 µM 1.0074184851911 0.170026099647867 no 621 0.156866855933004 844 6756808
SGTC_140 0062-0056 502.533 µM 1.00545207076952 0.170479295792874 no 622 0.157339608698478 856 3758964
SGTC_2382 9035899 200 µM 1.0051872728466 0.170540382358068 no 623 0.157403341197783 816 6462679
SGTC_2263 7948595 193.29 µM 1.00359135176106 0.170908844127309 no 624 0.157787812386388 737 2971371
SGTC_828 2074-0507 139 µM 1.00157607905088 0.171374851735759 no 625 0.158274189472176 825 X828
SGTC_2213 7173844 200 µM 0.99988255005626 0.171767087415951 no 626 0.15868367504837 818 892728
SGTC_1383 3049-0032 20.7 µM 0.998845524843546 0.172007554078368 no 627 0.158934764372318 818 712864
SGTC_2802 7925815 54.55 µM 0.994808836473691 0.172945631453655 no 628 0.159914623851526 799 1262923
SGTC_809 3998-0021 90 µM 0.992820670136072 0.173408853019056 no 629 0.160398677448131 784 715485
SGTC_1465 k213-0056 144 µM 0.991698232425633 0.17367071751558 no 630 0.160672376782185 783 24048857 YMR208W ERG12
SGTC_2130 NSC 7 2.4545 µM 0.991412802488156 0.173737348366045 no 631 0.160742025681062 844 21448
SGTC_2384 9036245 200 µM 0.987946834344029 0.17454774232668 no 632 0.161589343339906 834 6462766
SGTC_1220 1838-0075 193 µM 0.987201567484688 0.174722309692999 no 633 0.161771916764703 833 5529645
SGTC_1250 0485-0349 40.2 µM 0.986437721348329 0.174901343943169 no 634 0.161959181130164 776 6842794 YDL195W SEC31
SGTC_1048 3161-0300 24.5 µM 0.985162467832532 0.175200503857296 no 635 0.162272136573042 838 2165101
SGTC_1265 0819-1001 68.8 µM 0.98066319079399 0.176258573221293 no 636 0.163379430736753 779 3106768
SGTC_179 1273-0063 6.77 µM 0.980068389019923 0.176398751375163 no 637 0.163526180834153 773 3108139
SGTC_877 0771-0151 33.1 µM 0.97913373779625 0.17661916499175 no 638 0.163756951811923 837 6166523
SGTC_672 1441-0018 53.7 µM 0.97292180378818 0.178088513129547 no 639 0.165296083729925 778 251141
SGTC_1164 k060-0068 93.7 µM 0.971848033505254 0.178343277802 no 640 0.165563077843627 871 5963676
SGTC_2699 st077704 54.6 µM 0.971168836360504 0.178504543847957 no 641 0.165732104862527 817 645852
SGTC_982 1491-0518 27.5 µM 0.97089085621955 0.178570572900793 no 642 0.165801315990679 780 3091256
SGTC_3080 9117754 49.47 µM 0.97029479331993 0.178712208490208 no 643 0.165949785920947 898 9550191
SGTC_1014 4130-3005 69.3 µM 0.969589288465556 0.178879940891561 no 644 0.16612562712468 833 743608
SGTC_481 bay k-8644 50 µM 0.969081953302948 0.179000620059787 no 645 0.166252150559765 762 2303 A calcium channel antagonist.
SGTC_2842 9000675 19.48 µM 0.968890919440914 0.179046074314542 no 646 0.166299808288276 768 2989072
SGTC_741 4582-0002 126 µM 0.967908738838759 0.179279887243527 no 647 0.166544974783916 817 2912688
SGTC_3122 9126309 49.47 µM 0.966605021456064 0.179590540028637 no 648 0.166870761692852 884 17591206
SGTC_1935 st074532 41.6 µM 0.96631365190703 0.179660014461093 no 649 0.166943628413747 916 2829742
SGTC_1051 3253-3903 78 µM 0.965569833146347 0.179837447886742 no 650 0.167129738273688 874 5509239
SGTC_1021 4476-0760 85.3 µM 0.964122667280342 0.180182975745525 no 651 0.167492214781103 790 746768
SGTC_673 1082-0474 110 µM 0.963027266577003 0.180444792422153 no 652 0.167766920007624 918 3098046
SGTC_2422 chlorphenesin carbamate 384.24 µM 0.96072523320941 0.180995789152013 no 653 0.168345170165681 855 2724 A muscle relaxant with antifungal properties.
SGTC_968 1309-0633 340 µM 0.959815434288059 0.18121384187453 no 654 0.168574056498415 847 3761976
SGTC_92 0063-0024 660.874 µM 0.957560587787615 0.18175497277754 no 655 0.169142190481866 943 3594437
SGTC_943 3253-1379 105 µM 0.954821661263787 0.182413634154745 no 656 0.169833945622295 841 668464
SGTC_1903 st060211 78.3 µM 0.954352773504563 0.182526542334625 no 657 0.169952551555061 900 688960
SGTC_1959 st077091 55.8 µM 0.953944223774709 0.182624956694001 no 658 0.170055938162523 872 821356 YKL052C ASK1
SGTC_2007 4011539 71.82 µM 0.953782469987186 0.182663930249576 no 659 0.170096882321961 835 45595301
SGTC_2060 5238662 140 µM 0.951661967395589 0.183175332186354 no 660 0.170634221788013 798 790130
SGTC_451 chloral hydrate 100 µM 0.948019939546808 0.184055762309461 no 661 0.171559651701722 913 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1
SGTC_3024 9090631 49.47 µM 0.947248933654626 0.184242483959194 no 662 0.171755972876973 820 25236383
SGTC_1468 k284-1086 134 µM 0.943293027001311 0.185202375570831 no 663 0.172765520771547 907 15996457
SGTC_2184 6075246 200 µM 0.942495613883137 0.185396241490884 no 664 0.172969477835341 851 2267320
SGTC_1422 4031-0024 15.5 µM 0.941297740731571 0.185687703339723 no 665 0.173276150111875 855 782427
SGTC_2893 9048488 25.97 µM 0.940988983805163 0.185762874932402 no 666 0.17335525228706 835 6467338
SGTC_1308 1187-1617 41.4 µM 0.94078360726535 0.18581288744265 no 667 0.173407881588694 885 2882570
SGTC_920 mycophenolic acid 780.421 nM 0.940322728510557 0.185925149270951 no 668 0.173526022294784 822 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_1624 st003710 6.25 µM 0.940019208235792 0.185999104349934 no 669 0.173603854022002 913 24207033
SGTC_2189 6047310 154.431 µM 0.93601586415209 0.186976256340405 no 670 0.174632509892845 829 711535
SGTC_2418 pentamidine 31.67 µM 0.928599503979609 0.188794843784838 no 671 0.176548339515567 821 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_1537 2',6'-dihydroxyflavanone 78 µM 0.927155337766158 0.189150235896481 no 672 0.176922943947005 925 5106787 A p450 inhibitor.
SGTC_2923 7992654 58.14 µM 0.926513639190268 0.18930828238555 no 673 0.177089556165164 855 2985126
SGTC_2867 9039098 71.43 µM 0.926497857680119 0.189312170300265 no 674 0.177093654964258 840 6463460
SGTC_448 monastrol 171 µM 0.926357284562326 0.189346803900975 no 675 0.177130167484028 899 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity
SGTC_2643 anethole 100 µM 0.926084292680722 0.189414073219633 no 676 0.17720108809164 923 637563 An anti-fungal, anti-helmenthic and channel blocker.
SGTC_683 panaxydol 45 µM 0.925502364618399 0.189557518161499 no 677 0.17735232713549 907 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis.
SGTC_1179 1021-1431 9.29 µM 0.925073463454927 0.18966328483068 no 678 0.177463847711041 917 2840958
SGTC_2297 7971671 152.32 µM 0.922802037440168 0.190224021556844 no 679 0.178055189436257 869 909016
SGTC_2817 7995342 71.43 µM 0.918173622000192 0.191369765652902 no 680 0.179263988043867 807 18879975
SGTC_2776 terbinafine 19.92 µM 0.916602288390781 0.19175970208265 no 681 0.179675542394565 875 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_281 1672-3440 14.9 µM 0.910140609866481 0.193368316435611 no 682 0.181374180123526 955 6833000
SGTC_2619 obliquin 87.91 µM 0.909572361178712 0.193510172943847 no 683 0.181524040075706 939 6708593 A bioactive alkalod. YER133W GLC7
SGTC_609 0986-0026 86.3 µM 0.908105615097539 0.193876621889729 no 684 0.181911212050658 901 2848610
SGTC_1901 st060216 58.6 µM 0.907742538986622 0.19396739737301 no 685 0.182007131702902 922 688792
SGTC_854 0422-0053 192 µM 0.906723636332152 0.194222279443642 no 686 0.182276480455963 923 3596728
SGTC_3046 9092212 49.47 µM 0.905649396678124 0.194491225040441 no 687 0.182560727248489 884 25236637
SGTC_521 r062-0005 13.8 µM 0.903045311486823 0.195144121401036 no 688 0.183250923559098 880 2832033
SGTC_3182 9108849 49.47 µM 0.903002010184039 0.195154989152999 no 689 0.18326241403285 937 17133045
SGTC_282 k297-0036 65.7 µM 0.902204544311213 0.195355202734644 no 690 0.183474110642871 888 5061378
SGTC_333 3486-0131 40.1 µM 0.90139732589306 0.195557991842417 no 691 0.183688551351726 960 6744690
SGTC_1798 st045719 60.953 µM 0.90002728272153 0.195902466022325 no 692 0.18405286590611 867 3980186
SGTC_1429 4049-0205 9.46 µM 0.89883351897402 0.196202917688488 no 693 0.184370671653999 947 22774478
SGTC_2345 9052315 157.45 µM 0.898247202727698 0.196350586579246 no 694 0.184526886673365 878 6469265
SGTC_194 1486-1323 56.904 µM 0.896042153865436 0.196906550328998 no 695 0.185115124943865 908 5178754
SGTC_587 k089-0003 57 µM 0.894701735135065 0.197244978288343 no 696 0.185473275455616 825 9659696
SGTC_13 0199-0087 65 µM 0.894362421499793 0.197330703731333 no 697 0.185564005858508 972 4589825
SGTC_3054 9094397 49.47 µM 0.89218536157648 0.197881260086444 no 698 0.186146793512843 962 2598354
SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM 0.891116289354332 0.198151956982298 no 699 0.186433393459416 948 4174840
SGTC_3043 9092303 49.47 µM 0.889372149347029 0.198594065578238 no 700 0.186901553842505 889 25236084
SGTC_1765 st044815 90.4 µM 0.88766253912852 0.199027998370703 no 701 0.187361151103664 905 645695
SGTC_2135 5326629 150.42 µM 0.886518963511692 0.199318579052389 no 702 0.187668969994559 875 5020077
SGTC_906 1165-0455 526 µM 0.882831828018232 0.200257212334785 no 703 0.188663570557493 896 3252859
SGTC_2266 7929956 200 µM 0.881026373719968 0.200717793534832 no 704 0.189151772674853 928 2967153
SGTC_484 loperamide 105 µM 0.880872778334569 0.200757005879109 no 705 0.189193341361796 870 3955 An opioid-receptor agonist.
SGTC_2232 chlorophetanol 41.5365 µM 0.88001909791183 0.200975031175122 no 706 0.18942448188393 1055 15907 An antifungal of unknown mechanism. YFR051C RET2
SGTC_337 1315-0038 354 µM 0.879613448871881 0.20107868148078 no 707 0.189534375358098 913 1626437
SGTC_3240 9133527 49.47 µM 0.879443329043056 0.201122159563382 no 708 0.189580473813184 904 17617455
SGTC_973 1325-0077 65.9 µM 0.878690642586789 0.20131459375581 no 709 0.189784516827683 1001 2835149
SGTC_1922 5578187 25 µM 0.877541511341917 0.201608597066867 no 710 0.190096290971771 910 1350412
SGTC_218 alverine citrate 93.75 µM 0.875959953806054 0.202013656274857 no 711 0.190525902312762 906 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_3273 9137859 49.47 µM 0.874361159451491 0.202423624747184 no 712 0.190960801189897 950 2377234
SGTC_2331 7980721 200 µM 0.873698233438644 0.202593760370975 no 713 0.191141306626463 954 2981221
SGTC_3135 9127742 49.47 µM 0.873270521325576 0.20270357523522 no 714 0.191257822127757 880 3643468
SGTC_2412 st077135 33.4 µM 0.872646915322098 0.20286374947757 no 715 0.191427780198724 928 13258915
SGTC_3162 9099653 49.47 µM 0.871521330662261 0.203153049094987 no 716 0.191734782109821 922 25237511
SGTC_2902 5787006 60.46 µM 0.87020810855526 0.203490886704033 no 717 0.19209334274784 898 591003
SGTC_1425 4048-4433 7.33 µM 0.869221933809699 0.203744808772048 no 718 0.192362876308925 1003 23734946
SGTC_441 propafenone 146 µM 0.869121527669246 0.203770672118578 no 719 0.192390331495139 948 4932 Slows the influx of sodium ions into the cardiac muscle.
SGTC_1612 st002233 45.4 µM 0.868887473994233 0.203830968970558 no 720 0.192454340740036 933 1035021
SGTC_596 1155-0152 116 µM 0.868081867190481 0.204038590485905 no 721 0.192674758451714 964 280313
SGTC_1441 4106-0040 13 µM 0.867690361503379 0.204139535065268 no 722 0.192781931880622 972 2904180
SGTC_2391 6285546 200 µM 0.86511048092922 0.204805466751999 no 723 0.193489076317491 974 846083
SGTC_2320 7373003 200 µM 0.862646861022512 0.205442592994456 no 724 0.194165828584044 978 5415828
SGTC_1064 honokiol 6.76 µM 0.862524959060445 0.205474149061613 no 725 0.194199352241175 949 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis.
SGTC_1011 4112-3381 17.4 µM 0.861204711591193 0.205816098359747 no 726 0.194562652781191 929 2877139
SGTC_1337 1486-1011 40.3 µM 0.861152675668043 0.205829582781603 no 727 0.194576980290332 1000 X1337
SGTC_2844 9010103 25.97 µM 0.860299051255749 0.206050863087269 no 728 0.194812107868277 903 2480525
SGTC_428 3448-4153 16.5 µM 0.86028489797668 0.206054533151535 no 729 0.194816007790694 875 3834874
SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM 0.859163359406848 0.206345480759293 no 730 0.195125197615813 915 279621
SGTC_321 4534-3890 65.3 µM 0.858828791194242 0.206432320992508 no 731 0.195217490322392 991 699746
SGTC_2270 7924575 90.91 µM 0.858508890912765 0.206515374277351 no 732 0.195305761593859 979 1262135
SGTC_1802 st050112 57.9 µM 0.857359746967043 0.206813881027334 no 733 0.195623049109939 1003 4662563
SGTC_456 gingerol 170 µM 0.856506610683988 0.207035660621493 no 734 0.195858808918424 1026 442793 A herb.
SGTC_2936 9038235 15.59 µM 0.854022351058366 0.207682264707107 no 735 0.19654630263391 985 4749415
SGTC_1317 1273-0028 910 nM 0.8535583727221 0.207803161258097 no 736 0.19667486579832 984 5917803 YLR359W | YHR072W ADE13 | ERG7
SGTC_2293 7624732 200 µM 0.849823364027511 0.208777887172289 no 737 0.197711648939432 956 894453
SGTC_2104 5389443 200 µM 0.848326237683671 0.209169347692418 no 738 0.198128154666047 1009 2244536
SGTC_2257 7960413 200 µM 0.84795244942034 0.209267151203244 no 739 0.198232226439284 1003 2974689 YIL048W NEO1
SGTC_2072 5231554 129 µM 0.847670304139583 0.209340993707792 no 740 0.198310804420173 1075 789545
SGTC_3097 9117246 49.47 µM 0.846469701406334 0.209655384491545 no 741 0.198645384630461 1006 16423892
SGTC_670 4204-0025 119 µM 0.844904029152743 0.210065789537572 no 742 0.199082212342794 1013 719039
SGTC_3354 9151612 71.43 µM 0.844748947332201 0.210106466352728 no 743 0.199125512160328 1000 27261949
SGTC_2024 5144227 134 µM 0.843785353054412 0.21035931368564 no 744 0.199394680848757 1005 3475211
SGTC_2395 5646831 180.19 µM 0.84197071016781 0.210835961047112 no 745 0.199902174250645 954 6808628
SGTC_2284 7945075 39.21 µM 0.841275709560805 0.211018682599577 no 746 0.200096747630493 1060 1245402
SGTC_2274 7947094 46.08 µM 0.841226898168549 0.211031519016253 no 747 0.200110417215907 1050 2971028
SGTC_1032 k061-1018 98.7 µM 0.841219332992275 0.211033508546772 no 748 0.200112535886789 1058 4005393
SGTC_960 1222-0186 7.7 µM 0.839215592824756 0.21156084986121 no 749 0.200674169398056 975 3126296
SGTC_2168 5727979 200 µM 0.837307163537576 0.21206382398105 no 750 0.201209966834512 943 695210
SGTC_662 k832-1615 104 µM 0.830521328368455 0.21385791197036 no 751 0.203122047062169 954 5878478
SGTC_1438 4092-1045 4 µM 0.826945699557489 0.214806807032009 no 752 0.204133919722489 1014 1351342
SGTC_3047 9092122 49.47 µM 0.826004121172475 0.215057087977196 no 753 0.204400877008054 990 17173831
SGTC_2219 9098279 200 µM 0.825506618635108 0.215189397461016 no 754 0.204542013317193 1011 902349
SGTC_2982 9019404 25.97 µM 0.823109915387487 0.215827456075312 no 755 0.205222745362098 941 22333232
SGTC_2183 6420625 130.508 µM 0.822227279645356 0.216062710380234 no 756 0.205473777818227 1063 2897619
SGTC_383 2324-0395 7.37 µM 0.822063064431639 0.216106496048126 no 757 0.205520502753626 1025 3146421
SGTC_2149 5554786 194.827 µM 0.820812828322515 0.216440022316048 no 758 0.205876445180496 1041 745063 YPR165W RHO1
SGTC_972 1319-0219 195 µM 0.820421062682684 0.216544595145179 no 759 0.205988056132628 970 23903702
SGTC_655 k060-0012 42 µM 0.818857502376639 0.216962242644679 no 760 0.206433859468569 982 5994525
SGTC_2758 dehydroepiandrosterone 69.35 µM 0.815621958557167 0.217827975875328 no 761 0.207358193240217 1010 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem]
SGTC_3171 9103192 49.47 µM 0.815564064393162 0.217843484717759 no 762 0.207374754762528 1086 13018434
SGTC_2347 9049783 174.81 µM 0.814937576565668 0.218011350669415 no 763 0.207554021321772 1041 6467988 YPL169C MEX67
SGTC_2908 7930301 100 µM 0.812883599521156 0.218562231794435 no 764 0.208142399204526 1036 2223178
SGTC_2712 st079126 47.7 µM 0.812000475262233 0.218799333801129 no 765 0.20839567939242 997 3152970
SGTC_760 0568-0725 82.9 µM 0.811588410180717 0.218910016032146 no 766 0.208513921899168 1067 3916171
SGTC_756 0508-1999 28.3 µM 0.811354737153753 0.218972795794996 no 767 0.208580992192667 989 6753853
SGTC_1467 k284-1082 293 µM 0.810272840598134 0.21926359846229 no 768 0.208891690634082 1031 3334705
SGTC_1296 1068-0102 11.9 µM 0.808681553439666 0.219691723173107 no 769 0.209349170678736 1008 767053
SGTC_927 2425-1185 123 µM 0.807456329208107 0.220021688008097 no 770 0.209701812506825 1033 730375
SGTC_1338 1486-1223 76 µM 0.806404727587326 0.220305121187156 no 771 0.210004760952879 1045 3444526
SGTC_1252 0493-0875 34.8 µM 0.805212991896387 0.220626576921927 no 772 0.210348390292062 997 3960963
SGTC_2313 7726885 200 µM 0.80367758485649 0.221041129527543 no 773 0.21079160136473 996 726423
SGTC_1085 doxorubicin 7.67 µM 0.803506768284663 0.221087276729643 no 774 0.210840943163874 1090 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_2050 5263056 171 µM 0.797903332688481 0.222604134781948 no 775 0.212463294627077 1079 763468 YGL055W OLE1
SGTC_2996 9066192 71.4286 µM 0.797545883358071 0.222701097719773 no 776 0.212567033075116 1054 6472854
SGTC_1292 0kpi-0043 232 µM 0.795709516996883 0.223199616137222 no 777 0.213100446971309 1008 3333905
SGTC_643 k048-0106 28.4 µM 0.795421578285463 0.223277840438067 no 778 0.213184156000319 1041 6763920
SGTC_599 1935-0052 86.5 µM 0.794667926875535 0.22348265874418 no 779 0.213403346961523 1078 9557311
SGTC_157 1348-1695 65.819 µM 0.794220255692718 0.223604372010476 no 780 0.213533609214977 1039 5380510
SGTC_320 4092-0846 5.34 µM 0.793857495722887 0.223703027179538 no 781 0.213639198191001 1057 1359356
SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM 0.79370962897525 0.22374324769797 no 782 0.213682246666113 1029 2724278 An inhibitor of dopamine biosynthesis.
SGTC_2946 9065502 71.43 µM 0.79366629551891 0.223755035400591 no 783 0.213694863301052 886 16489101
SGTC_18 0111-0177 500 nM 0.793548041423221 0.22378720504657 no 784 0.213729295459293 1148 721752
SGTC_1101 ebselen 5.29 µM 0.792810909626081 0.223987792406649 no 785 0.213943999671479 1130 3194 A potent scavenger of hydrogen peroxide and hydroperoxides.
SGTC_3050 9093513 49.47 µM 0.792243208139752 0.224142344211956 no 786 0.214109439510883 1110 25236664
SGTC_1972 st070201 17.4 µM 0.792074491656519 0.224188287482744 no 787 0.214158621296149 1041 2829099
SGTC_48 0382-0018 55 µM 0.789813995356312 0.224804359957023 no 788 0.21481820221304 1093 762596
SGTC_1550 gossypolone 36.6 µM 0.78862560770227 0.225128626043019 no 789 0.21516542973635 1088 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_288 1315-0019 35.1 µM 0.788285291336981 0.225221534304663 no 790 0.215264924611634 1064 6811474
SGTC_43 0570-0105 72.5 µM 0.787551990904607 0.225421803200921 no 791 0.215479403015176 1088 1114046 YDL195W SEC31
SGTC_1102 cgs 12066b 26.1 µM 0.787450011866211 0.225449662291765 no 792 0.215509240033234 1015 6438352 A 5-HT1B full agonist.
SGTC_1688 st021091 57.6 µM 0.786740573828134 0.225643523689175 no 793 0.215716873660614 1087 3656366
SGTC_667 1498-1044 59 µM 0.785650813173894 0.225941495878642 no 794 0.216036043375055 1077 6739982
SGTC_1893 st059353 36.1 µM 0.784164555468632 0.226348240257447 no 795 0.216471780016456 1026 3112488
SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM 0.783698237000661 0.226475942891886 no 796 0.216608598629291 1098 676296 Flavone; oxidizing agent.
SGTC_1683 st010134 710 nM 0.783109017652199 0.226637360442368 no 797 0.216781548080479 1088 3818134
SGTC_664 1222-0054 14.9 µM 0.782768979802059 0.226730543878629 no 798 0.216881393347957 1082 6813991
SGTC_2775 cyproheptadine 69.59 µM 0.7821023685658 0.226913283690617 no 799 0.217077207438076 1110 2913 A selective serotonin reuptake inhibitor.
SGTC_552 k242-0005 476 µM 0.775498876367559 0.228727996628606 no 800 0.219022464584242 1062 4088318
SGTC_2087 5276107 200 µM 0.774799772607431 0.228920593938743 no 801 0.219228991840049 1087 144405
SGTC_1174 0739-0097 51.1 µM 0.774272847135801 0.229065817680227 no 802 0.219384728629167 1060 728447
SGTC_144 4161-2749 112.381 µM 0.773688797965746 0.229226845418467 no 803 0.219557423015418 977 797501 YMR168C CEP3
SGTC_1028 k015-0029 4.8 µM 0.77350023106602 0.229278848602371 no 804 0.219613196026465 1113 4588309
SGTC_2860 9025725 38.96 µM 0.773210357221802 0.229358803223295 no 805 0.219698948768986 1023 40546248
SGTC_1498 4478-3555 97.6 µM 0.772567435236585 0.229536193314844 no 806 0.219889211559481 1060 3437919
SGTC_2965 9082772 38.63 µM 0.772377476842724 0.229588619882406 no 807 0.219945444892035 1116 16459634
SGTC_397 arbidol 50 µM 0.77139685806774 0.229859367277425 no 808 0.220235868428011 1103 131410 A RNA synthesis inhibitor.
SGTC_1140 3229-1848 2.98 µM 0.771217890346798 0.229908799281884 no 809 0.220288895861527 1102 2849525
SGTC_543 3844-1095 191 µM 0.770978424808168 0.229974950469184 no 810 0.220359860010055 1097 4230703
SGTC_228 caffeine 993.056 µM 0.770976390377249 0.229975512516436 no 811 0.220360462957356 1039 2519 Caffeine is a phosphodiesterase inhibitor.
SGTC_792 4534-1957 155 µM 0.770622180330615 0.230073380977757 no 812 0.220465455128282 1048 1717904
SGTC_2570 licareol 100 µM 0.770069448122869 0.230226147784263 no 813 0.220629348944407 1012 443158
SGTC_2462 5162487 171.77 µM 0.769432027263567 0.230402391669625 no 814 0.220818440910135 1100 2259986
SGTC_2296 7971656 126.45 µM 0.767791833157235 0.230856244247489 no 815 0.221305433614707 1088 666570
SGTC_1770 st043884 66.3 µM 0.765107058801887 0.231600215353837 no 816 0.222103898451976 1113 670149
SGTC_3222 9128301 49.47 µM 0.764910298667826 0.231654791568777 no 817 0.222162480465917 1122 4911358
SGTC_561 1550-0330 72.9 µM 0.763909877699757 0.231932393521531 no 818 0.222460475319491 1066 6812934
SGTC_3350 9150499 3.57 µM 0.763810478183826 0.231959985524267 no 819 0.222490095844238 1118 4910996 YPR165W RHO1
SGTC_2971 9092186 9.93 µM 0.761165981566624 0.232694733963135 no 820 0.223278967156954 1035 25236400
SGTC_1152 3909-8331 15.9 µM 0.761092930258892 0.232715048923195 no 821 0.223300781429997 1066 16001939
SGTC_3096 9117468 49.47 µM 0.761077763673392 0.232719266747826 no 822 0.223305310563764 1011 41316311
SGTC_1233 0325-0408 14.2 µM 0.760704095816533 0.23282319712689 no 823 0.223416913937537 1080 12874
SGTC_713 1488-1073 324 µM 0.760023927756145 0.233012442337652 no 824 0.22362014115658 1098 3312542
SGTC_1307 1187-1599 12.2 µM 0.759721161193334 0.233096709459822 no 825 0.223710638492423 1102 1538471
SGTC_1462 k081-0014 26.5 µM 0.759518515705028 0.233153119961136 no 826 0.223771221133789 917 3270634
SGTC_1848 st056003 16.4 µM 0.75773669905015 0.233649451082644 no 827 0.224304312166557 1173 146492
SGTC_2192 5915882 198.485 µM 0.757627859087694 0.233679787798937 no 828 0.224336898690194 1059 2876149
SGTC_7 0192-1582 4.227 µM 0.753467153366231 0.234841127781909 no 829 0.225584621134268 1149 252616
SGTC_1625 st003711 30.1 µM 0.752191147678384 0.235197925798139 no 830 0.225968058196772 1131 24207034 YER133W GLC7
SGTC_2594 a-mangostin 100 µM 0.752142392123015 0.235211564811337 no 831 0.225982716444899 1107 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis.
SGTC_1108 betulinic acid 729.144 nM 0.751163102956285 0.235485606321428 no 832 0.226277251341767 1134 64945 Apoptosis-inducing agent of unknown mechanism.
SGTC_1672 st016598 6.51 µM 0.75008347507557 0.235787930403487 no 833 0.226602215693857 1047 4665860 YNL267W PIK1
SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM 0.749800999112746 0.235867066377437 no 834 0.226687283464923 1128 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1
SGTC_1325 1431-0015 227 µM 0.749581555532994 0.235928553858619 no 835 0.226753381440511 1067 1103340
SGTC_2273 7815444 169.05 µM 0.748521579606488 0.23622568053072 no 836 0.227072806853316 1099 2824616
SGTC_1218 1348-1416 30.7 µM 0.747327618276644 0.236560611919135 no 837 0.227432912605412 1125 6787668
SGTC_517 1365-0151 113 µM 0.74584729703334 0.236976235888673 no 838 0.227879832517025 1115 768657
SGTC_3072 9116419 49.47 µM 0.744601124197076 0.237326429862875 no 839 0.228256444064654 1103 17170162
SGTC_1671 st016596 74.5 µM 0.743206482522499 0.237718682646235 no 840 0.228678339623885 1175 2829167
SGTC_347 4534-1311 26.2 µM 0.743162505167076 0.237731057368411 no 841 0.228691650410402 1146 2862016
SGTC_325 2810-4341 181 µM 0.741608195986765 0.238168648977572 no 842 0.229162378153193 1140 774970
SGTC_1130 3454-2858 15.9 µM 0.740624417683969 0.238445844391284 no 843 0.229460599304013 1055 715628 YIL048W NEO1
SGTC_736 0958-0254 92.6 µM 0.738911009240847 0.238929046323226 no 844 0.229980518383811 1156 6812352
SGTC_319 1348-1596 45.5 µM 0.738372915553082 0.239080905670017 no 845 0.230143934232812 1153 5380505
SGTC_1327 1436-0082 2.18 µM 0.736650956550676 0.239567226654454 no 846 0.230667319247572 1085 15992205
SGTC_563 tetrahydrosecaminediol 614 µM 0.736069693883186 0.239731510484589 no 847 0.230844142550652 1166 334274 A psychoactive constituent of the cannabis plant.
SGTC_2161 5662504 8.5105 µM 0.736005446053541 0.239749672793543 no 848 0.230863691738786 1082 2859334
SGTC_2695 st077686 51.995 µM 0.733228280391556 0.240535470853579 no 849 0.231709604716878 1137 2876092
SGTC_1782 st039423 80.636 µM 0.73263138866598 0.240704544069293 no 850 0.231891640653491 1107 2068169
SGTC_3315 9136395 68.55 µM 0.732056339961745 0.240867491270391 no 851 0.232067090360632 1192 16876844
SGTC_1162 k048-0130 20.1 µM 0.732008828906917 0.240880956801924 no 852 0.2320815894817 1106 6797406
SGTC_1614 st002383 48.6 µM 0.731707394833411 0.240966398459811 no 853 0.232173590960208 1183 1947235
SGTC_1670 st016595 4.04 µM 0.731619254745689 0.240991384931435 no 854 0.232200496260684 1156 597879
SGTC_3058 9093861 49.47 µM 0.731578415087896 0.24100296287604 no 855 0.232212963404053 1137 17217477
SGTC_851 0394-0702 453 µM 0.731562147308788 0.241007574836473 no 856 0.2322179295811 1165 762646
SGTC_1361 1608-0041 5.61 µM 0.731416067316446 0.241048991069374 no 857 0.232262527075307 1135 X1361
SGTC_826 1683-5028 118 µM 0.731402196621339 0.241052923855219 no 858 0.232266761977177 1134 722377
SGTC_3221 9128209 49.47 µM 0.730902784126674 0.241194546515749 no 859 0.23241926766259 1128 16460723
SGTC_721 1187-1332 279 µM 0.730205818089956 0.241392266695199 no 860 0.232632193376883 1065 25730
SGTC_1963 st076565 50.3 µM 0.727203136284892 0.242245094326052 no 861 0.233550762617646 1174 4914280
SGTC_2664 lyso-paf C-16 73.48 µM 0.726541713476279 0.242433172188423 no 862 0.233753372624442 1163 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_1518 st038567 90.8 µM 0.726019052239634 0.242581848653388 no 863 0.233913545449239 1162 77966
SGTC_788 1182-0090 188 µM 0.725520456266717 0.242723725506896 no 864 0.23406639997974 1207 5715185
SGTC_1059 3448-6867 171 µM 0.725271064857178 0.242794707366417 no 865 0.234142876636127 1151 3934407
SGTC_905 2-aminofluorene 215 µM 0.724597037533175 0.242986605430181 no 866 0.234349638438741 1208 1539 An established DNA mutagen. YPR165W RHO1
SGTC_185 k048-0037 25.491 µM 0.722954449016885 0.243454599829903 no 867 0.23485393493942 1175 6827589
SGTC_1243 0416-0003 5.65 µM 0.72284803103365 0.243484936456682 no 868 0.234886627349494 1146 2141977
SGTC_560 2332-1943 155 µM 0.720811616699389 0.244065851331457 no 869 0.235512713572313 1158 21177716
SGTC_390 dec-rvkr-cmk 16.7 µM 0.720451043044133 0.24416878771127 no 870 0.23562366615837 1188 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1
SGTC_1107 amlodipine 47 µM 0.71773140011256 0.244945943569055 no 871 0.236461459198373 1083 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.
SGTC_65 0798-0905 34.986 µM 0.715372984804983 0.24562095229678 no 872 0.237189300494358 1225 3602145
SGTC_2896 9052656 71.43 µM 0.715347949547798 0.24562812306366 no 873 0.237197033335067 1157 6469436
SGTC_1693 xanthone 101.9 µM 0.714625221538988 0.245835180149567 no 874 0.237420327828978 1179 7020 An insecticide.
SGTC_3269 9137823 49.47 µM 0.713210422871389 0.246240782247251 no 875 0.237857778791146 1111 17682936
SGTC_1342 1486-1464 234 µM 0.712670148276033 0.246395765694911 no 876 0.238024946416836 1202 3253938
SGTC_25 0118-0223 35.662 µM 0.712125919090759 0.246551936397602 no 877 0.238193402728146 1196 5333628
SGTC_802 4112-3352 742 µM 0.711904746743609 0.246615418634939 no 878 0.238261881294584 1197 704594
SGTC_1071 trifluoperazine 6.31 µM 0.710839178267833 0.246921387262553 no 879 0.23859194976687 1197 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels.
SGTC_862 0452-0056 10.2 µM 0.710647812386384 0.246976357804927 no 880 0.238651253396571 1129 1575396 YLR359W | YHR072W ADE13 | ERG7
SGTC_1150 3909-7983 10.9 µM 0.708546293483018 0.247580457290694 no 881 0.239303037277657 1181 23965914
SGTC_629 3448-6466 76.7 µM 0.708226464230253 0.247672464087095 no 882 0.239402317174523 1180 573744
SGTC_799 1310-0557 151 µM 0.707037551339224 0.248014644340231 no 883 0.239771571095383 1184 5354492
SGTC_1712 st032288 53.4 µM 0.70702392475093 0.248018567661389 no 884 0.239775805057139 1186 2883011
SGTC_1908 st060353 56.5 µM 0.705520141540764 0.24845173522465 no 885 0.240243301004112 1202 4227716
SGTC_68 0986-0284 82.829 µM 0.704106221803496 0.248859384906234 no 886 0.240683312870802 1134 423278 YIL048W NEO1
SGTC_2506 ethyl hematommate 54.16 µM 0.703379256579073 0.249069116032563 no 887 0.240909715096303 1161 3940691 An allergen.
SGTC_24 0417-1663 219 µM 0.702460765530464 0.249334237197262 no 888 0.241195930686003 1168 4329390
SGTC_1260 0700-1617 7.75 µM 0.700825205066763 0.249806710637926 no 889 0.241706053131772 1183 2853078
SGTC_1201 1889-3372 45.9 µM 0.698979948016518 0.250340330418063 no 890 0.242282281154696 1126 5392199
SGTC_1913 st060213 96.1 µM 0.69870456798179 0.250420017849961 no 891 0.24236833931089 1200 688959
SGTC_1478 0453-0656 35.7 µM 0.698314010251964 0.250533057599447 no 892 0.242490419686473 1216 5258496
SGTC_2249 haloperidol 116.36 µM 0.698243314712588 0.250553522012115 no 893 0.24251252122892 1208 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_1193 1488-0126 41.5 µM 0.697986992386144 0.250627727696176 no 894 0.242592664411867 1222 1384710
SGTC_90 0870-0863 4.608 µM 0.697962612814436 0.250634786223662 no 895 0.242600287812983 1191 1738164
SGTC_923 1900-2434 73.3 µM 0.697911290334498 0.250649645776155 no 896 0.242616336584958 1187 5910570
SGTC_452 diindolylmethane 8 µM 0.695833032195222 0.251251761953508 no 897 0.243266700033656 1140 3071 Inhibits expression of several cancer promoting factors.
SGTC_2960 9079389 5.97 µM 0.695768941427219 0.251270342579661 no 898 0.243286771360847 1178 16457355
SGTC_2557 derrustone 83.84 µM 0.694587222717588 0.251613066128963 no 899 0.243657010954011 1203 629853 An antioxidant.
SGTC_808 0711-0032 135 µM 0.6927396802039 0.252149387162102 no 900 0.244236466277619 1187 4252555
SGTC_335 4077-0256 27.6 µM 0.69268302908989 0.252165841872658 no 901 0.24425424582207 1224 3121989
SGTC_873 0591-4978 488 µM 0.691944012512732 0.252380546255384 no 902 0.244486244761905 1251 3305145
SGTC_1964 st076914 61 µM 0.691276998947552 0.252574414509579 no 903 0.244695741735753 1217 24208661
SGTC_2374 9071832 200 µM 0.690824973188275 0.252705840897606 no 904 0.244837769831788 1174 17381698
SGTC_1834 st055981 52.8 µM 0.690619021685914 0.252765733190862 no 905 0.244902495234185 1225 471719 YDL150W RPC53
SGTC_622 1348-1566 26.3 µM 0.690541511171951 0.252788275784695 no 906 0.244926857233318 1230 7340407
SGTC_2760 etidronate 98.04 µM 0.689613496716066 0.253058254936229 no 907 0.245218638745838 1212 3305 A chelator and antioxidant.
SGTC_2858 9025781 8.96 µM 0.685878924785915 0.254146253039872 no 908 0.246394730580296 1240 4894980 YPL153C RAD53
SGTC_1293 1000-1278 195 µM 0.680930894408806 0.255591539392069 no 909 0.247957609187149 1264 678847
SGTC_2122 5258151 111.688 µM 0.680035526128582 0.255853528379672 no 910 0.24824098326908 1212 2173356
SGTC_2107 5363541 170.161 µM 0.679704477477313 0.255950430257595 no 911 0.248345800188313 1204 244052
SGTC_580 1123-0028 41 µM 0.678250888784144 0.256376139488408 no 912 0.248806315824903 1286 1677248 YPR107C YTH1
SGTC_341 1486-1430 230 µM 0.677934443826155 0.256468864891863 no 913 0.248906629893524 1202 2054753 YPL210C SRP72
SGTC_1617 st002906 78 µM 0.677746943276332 0.25652381496127 no 914 0.24896607832512 1237 5150859
SGTC_1486 3970-0793 4.53 µM 0.677483369797848 0.256601069801924 no 915 0.249049659014061 1247 2844330
SGTC_2208 7283366 200 µM 0.675511217743888 0.2571795027397 no 916 0.249675513393493 1234 898663
SGTC_202 3594-0513 34.79 µM 0.675232939931638 0.25726117627138 no 917 0.249763890917318 1204 708429
SGTC_2814 7977482 42.97 µM 0.674495218527907 0.2574777600661 no 918 0.249998262295459 1266 6456762
SGTC_2027 5150920 200 µM 0.67428524551743 0.257539422263711 no 919 0.250064991277652 1218 786715
SGTC_2791 5663188 71.43 µM 0.669561021234488 0.258928797144026 no 920 0.251568834504572 1219 54690634
SGTC_3184 9108758 49.47 µM 0.66900202880793 0.259093450674101 no 921 0.251747091892352 1241 902885
SGTC_1004 4084-0029 199 µM 0.667876139745016 0.259425250206721 no 922 0.252106329602117 1244 716894 YLR208W SEC13
SGTC_2362 9071156 126 µM 0.667692377000395 0.259479425919606 no 923 0.252164988486929 1248 653133
SGTC_887 0885-0007 9.62 µM 0.664936054602961 0.260292727141182 no 924 0.253045696883012 1283 5719458
SGTC_2150 5556613 200 µM 0.664859984577337 0.260315191545391 no 925 0.253070025932397 1255 743190
SGTC_564 3555-0129 330 µM 0.664333150591548 0.260470799441628 no 926 0.253238554056241 1162 563260
SGTC_483 fpl-64176 144 µM 0.662582653018815 0.260988177531043 no 927 0.253798941582382 1268 3423
SGTC_66 0109-0187 42.4 µM 0.662113863925719 0.261126822761291 no 928 0.253949125675089 1251 759417
SGTC_2705 st078069 42.8 µM 0.660906970346061 0.261483937845062 no 929 0.254335987839233 1230 1530061
SGTC_124 0136-0217 7.121 µM 0.657254798106432 0.262566126769361 no 930 0.255508547931223 1369 3976905
SGTC_328 k915-0120 63.5 µM 0.654524569822699 0.263376625680088 no 931 0.256386951519842 1236 6624543
SGTC_1155 4088-0394 48.2 µM 0.653096616353619 0.263801037870212 no 932 0.256846996758716 1232 2326248
SGTC_951 1171-0579 82.7 µM 0.652891974584246 0.263861889461375 no 933 0.256912961585662 1250 1616050 YPR165W | YDR526C RHO1 | YDR526C
SGTC_1352 1496-0991 99 µM 0.652517366922477 0.263973300078182 no 934 0.257033736549718 1254 3000039
SGTC_1126 isoteolin 1.0172 µM 0.652321284602663 0.264031625720486 no 935 0.257096966023368 1244 133323
SGTC_1600 coumarin 106 71.1 µM 0.651413909473628 0.26430161435682 no 936 0.257389667056351 1317 100336 A hepatotoxic, DNA x-linker.
SGTC_2311 7694451 200 µM 0.651179982696214 0.264371241838568 no 937 0.257465155211526 1242 2163142
SGTC_2407 paclitaxel 400 µM 0.646402297528318 0.265795342844753 no 938 0.259009426434937 1389 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_1415 3966-0071 78.1 µM 0.644035864756665 0.266502150732899 no 939 0.25977608875202 1271 2893185
SGTC_2587 piperic acid 92.2 µM 0.643844400824766 0.266559378863764 no 940 0.259838169223111 1238 5370536
SGTC_1986 st071812 45 µM 0.642185990132904 0.267055333924724 no 941 0.260376214189312 1262 11838594
SGTC_1706 st031321 9.9705 µM 0.642049197325835 0.267096263211355 no 942 0.260420620046889 1294 6103185
SGTC_3275 9138069 49.47 µM 0.641267889291355 0.267330096281467 no 943 0.260674324010869 1300 17617007
SGTC_1980 st071811 45.7 µM 0.641118824205877 0.267374720820522 no 944 0.26072274241692 1322 4974850
SGTC_2638 epoxomicin 18 µM 0.640345627188797 0.267606247511634 no 945 0.260973961763691 1283 9915668 A protesome inhibitor.
SGTC_2360 9040895 200 µM 0.638606350941109 0.268127426788072 no 946 0.261539524358117 1249 4914414
SGTC_1819 st053448 58.6 µM 0.635669147575127 0.269008726747165 no 947 0.262496044808466 1262 2857616
SGTC_1758 st042942 75.2445 µM 0.635050444985526 0.269194552014495 no 948 0.262697757650113 1259 669317
SGTC_406 estrone 100 µM 0.63483035003022 0.26926067232792 no 949 0.262769533343008 1345 5870 A steroid.
SGTC_108 0509-0257 621.132 µM 0.634334551189922 0.269409648670169 no 950 0.262931256230243 1278 536624
SGTC_3276 9139060 49.47 µM 0.63324796100467 0.269736288905447 no 951 0.263285865154614 1343 4870619
SGTC_2670 beta-carotene 100 µM 0.628256010431621 0.271239464890282 no 952 0.264918121857511 1233 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.)
SGTC_2476 5806916 10.51 µM 0.627198667103264 0.271558387155326 no 953 0.265264508418509 1228 2870194
SGTC_1106 tegaserod maleate 11.7 µM 0.626373567308019 0.271807388382229 no 954 0.265534971437162 1328 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation.
SGTC_1870 st057514 26.5 µM 0.626037600786873 0.271908809961649 no 955 0.265645139413952 1299 5393161
SGTC_2792 7535235 81.82 µM 0.625385031416989 0.272105861395917 no 956 0.265859191970881 1269 1281891
SGTC_1533 dihydroergotamine mesylate 29.4 µM 0.622473160546631 0.272986001255697 no 957 0.266815393367699 1339 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release.
SGTC_404 fumagillin 50 µM 0.6224090046662 0.273005408842913 no 958 0.266836480452741 1318 12015870 A methionine aminopeptidase binder.
SGTC_2762 leflunomide 42.06 µM 0.62227992284915 0.273044459037079 no 959 0.26687891028028 1317 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1
SGTC_1199 1638-0010 4.46 µM 0.622078560221198 0.273105381353353 no 960 0.266945105970818 1298 3111136
SGTC_2735 sertaconazole 140 nM 0.622049059127378 0.273114307482843 no 961 0.266954804818827 1382 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C
SGTC_1191 1487-1166 10.6 µM 0.621298293694011 0.273341514807466 no 962 0.267201688089445 1379 3955771
SGTC_1847 st056231 15 µM 0.620635945152307 0.273542041843922 no 963 0.267419591804092 1320 5393180
SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM 0.620109661633903 0.273701426878033 no 964 0.267592795845219 1337 4213774
SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM 0.620064118270534 0.273715221851225 no 965 0.267607787182271 1300 7104
SGTC_3237 9133362 49.47 µM 0.617355384657712 0.274536308609646 no 966 0.268500171512206 1311 43845137
SGTC_700 3453-2283 142 µM 0.617262401649588 0.2745645157077 no 967 0.268530831028593 1378 565664
SGTC_2262 9014885 67.46 µM 0.617029952651759 0.274635037121566 no 968 0.268607484707489 1267 6457424
SGTC_377 3970-0964 33.1 µM 0.616527279915822 0.274787570760963 no 969 0.268773286468425 1333 16481235
SGTC_2825 7998094 58.44 µM 0.615404836510083 0.27512832152476 no 970 0.269143699076799 1313 2987815
SGTC_2603 homopterocarpin 100 µM 0.61406185241673 0.275536297148646 no 971 0.269587227651641 1320 101795 A weak amylase inhibitor.
SGTC_724 3910-0327 137 µM 0.611618554749225 0.276279291436066 no 972 0.2703950794815 1301 2885483
SGTC_3356 9151811 4.48 µM 0.610058740231814 0.276754136581537 no 973 0.270911448504481 1304 1859254 YPR165W RHO1
SGTC_161 4065-0411 162.148 µM 0.609875574393664 0.27680992289971 no 974 0.270972116934321 1343 1906281 YLR208W SEC13
SGTC_735 3076-0345 636 µM 0.609701411240139 0.276862972402972 no 975 0.271029809769195 1391 2888990
SGTC_2502 avocadyne acetate 18.59 µM 0.609405821666329 0.276953019374827 no 976 0.271127740027562 1287 3952079
SGTC_1610 st001799 48.1 µM 0.609210856957123 0.277012420323473 no 977 0.271192342436708 1279 621897
SGTC_3351 9150312 21.596 µM 0.608778669747832 0.277144119360532 no 978 0.271335576915641 1327 4904905
SGTC_1995 st072814 61.1 µM 0.608310886257754 0.277286700055807 no 979 0.271490651105781 1266 5769371
SGTC_547 1120-0019 610 nM 0.607211102431972 0.277622056094648 no 980 0.271855412578058 1339 3676939
SGTC_605 1315-0399 119 µM 0.606857884364401 0.277729804568592 no 981 0.271972614895083 1378 24020461
SGTC_3051 9093778 49.47 µM 0.605587205738167 0.278117591377713 no 982 0.272394450183182 1334 17217378
SGTC_1227 3909-8010 46.6 µM 0.605564040354427 0.278124663460264 no 983 0.272402143558679 1336 15982272
SGTC_2146 5545642 200 µM 0.600327670546529 0.279725504102763 no 984 0.274143940596874 1343 825326
SGTC_3025 9087895 49.47 µM 0.599927602834244 0.27984799470535 no 985 0.274277242790834 1340 17173641
SGTC_941 3237-0776 460 µM 0.598983683360577 0.280137102009257 no 986 0.274591882677581 1398 760008
SGTC_2292 7671323 168.05 µM 0.59853752057294 0.280273804827017 no 987 0.274740665579951 1331 937504
SGTC_1652 st011932 78 µM 0.597057703816428 0.280727447011953 no 988 0.275234427748715 1343 1551076
SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM 0.597003259728062 0.28074414377828 no 989 0.275252602131116 1382 279621
SGTC_1597 7-benzyloxygramine 47.5 µM 0.596744689796299 0.280823447864517 no 990 0.275338925330161 1338 260807
SGTC_1983 st071813 46.9 µM 0.595118194446778 0.281322546516594 no 991 0.275882233744321 1335 11838595
SGTC_1907 st060210 83.7 µM 0.594825112638843 0.28141252571872 no 992 0.275980189666934 1382 688793
SGTC_114 0364-0001 490.298 µM 0.594716456328199 0.281445887879041 no 993 0.276016509905087 1314 4003655
SGTC_959 1222-0044 107 µM 0.594423188065467 0.28153594337378 no 994 0.276114551574888 1339 6083612
SGTC_3308 9128332 17.569 µM 0.59409395250246 0.281637060103216 no 995 0.276224637734812 1408 17332805 YDL196W YDL196W
SGTC_394 menadione 8.33 µM 0.593363235446106 0.281861544696057 no 996 0.276469043777543 1335 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_5 0352-0601 109.883 µM 0.59124876830398 0.282511618339012 no 997 0.277176875413726 1279 762456
SGTC_1279 0874-0590 65.2 µM 0.590840315973335 0.282637276312905 no 998 0.277313709596865 1369 3523074
SGTC_2660 2',4'-dihydroxychalcone 17.14 µM 0.590216321766767 0.28282929633643 no 999 0.277522815469747 1369 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_3327 9140648 26.9345 µM 0.589886847977343 0.282930709671801 no 1000 0.277633256071055 1363 8029710
SGTC_534 k292-0788 63.4 µM 0.589661368669712 0.283000123156232 no 1001 0.277708849783314 1413 4146317
SGTC_1938 st074717 56.4 µM 0.588138980392509 0.283469002033942 no 1002 0.278219505343125 1283 17250979
SGTC_1476 4112-3294 3.34 µM 0.585555877450949 0.284265420192782 no 1003 0.27908700314495 1422 704369
SGTC_1565 sinapyl alcohol 95.1 µM 0.583618307700182 0.284863509800688 no 1004 0.279738570053419 1321 5280507 A phenol propionate derived from cinnamic acid.
SGTC_2999 9069765 71.4286 µM 0.583313028073767 0.284957798324799 no 1005 0.279841296904661 1393 2097066
SGTC_216 k038-0035 28.382 µM 0.582552108025842 0.285192880503475 no 1006 0.280097426757084 1316 4444231 YPR107C YTH1
SGTC_159 3970-0959 50 µM 0.582232379342425 0.285291686538319 no 1007 0.280205083070861 1422 6615653
SGTC_1828 st055811 49 µM 0.580509978102848 0.285824242063431 no 1008 0.280785379946402 1338 5877589
SGTC_1722 st034304 3.6505 µM 0.576064969297555 0.287200790527532 no 1009 0.282285634157237 1371 4036148 YLR033W RSC58
SGTC_2079 5212404 121 µM 0.576015507670733 0.28721612564323 no 1010 0.28230234984126 1416 758462
SGTC_2807 7945238 51.95 µM 0.575973784843711 0.287229061717624 no 1011 0.282316450548291 1413 17148797
SGTC_2429 5902844 64.44 µM 0.575624373608031 0.287337406756312 no 1012 0.28243455137554 1411 1927790 YGL093W | YPR107C SPC105 | YTH1
SGTC_1589 2',5'-dimethoxyflavone 47.2 µM 0.574450925174266 0.287701409748457 no 1013 0.282831350175597 1346 688667
SGTC_1087 pterostilbene 9.05 µM 0.573626064233735 0.28795741145875 no 1014 0.283110435111787 1469 5281727 Similar to reservatol, lowers cholesterol.
SGTC_2163 5671233 125 µM 0.572463715528609 0.288318337442634 no 1015 0.283503930437461 1479 701023
SGTC_2661 dactinomycin 12.96 µM 0.572216098930655 0.288395253509514 no 1016 0.283587791092624 1375 45006140 An Actinomycin D Classic transcription inhibitor.
SGTC_419 nsc-638432 893 µM 0.572149490832397 0.288415945344251 no 1017 0.283610351377565 1381 368090
SGTC_2346 9031566 143.75 µM 0.571667077248936 0.288565828218606 no 1018 0.283773771401545 1411 4771086
SGTC_1090 efavirenz 20.7 µM 0.571130915467777 0.288732453366374 no 1019 0.283955451783158 1407 64139 A non-nucleoside reverse transcriptase inhibitor.
SGTC_2504 purpurogallin 52.29 µM 0.568965291852035 0.289405933537125 no 1020 0.28468984717005 1362 5281571 An antioxidant.
SGTC_3066 9117245 49.47 µM 0.567920896799428 0.289730990081698 no 1021 0.28504434093589 1478 17176980
SGTC_471 1-acyl-paf 4 µM 0.567350774893166 0.289908506553097 no 1022 0.285237943311435 1325 16759367
SGTC_2560 caryophyllene 100 µM 0.566239707907314 0.290254601314508 no 1023 0.285615420104005 1408 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor.
SGTC_316 k060-0003 58.6 µM 0.566208113100469 0.290264445852124 no 1024 0.285626157681184 1403 6152314
SGTC_380 3970-0968 6 µM 0.565624378589066 0.290446358189423 no 1025 0.285824575922788 1344 2891601
SGTC_3123 9126162 49.47 µM 0.564081164577217 0.290927535161366 no 1026 0.286349448022718 1422 25239884
SGTC_2668 2',4'-dihydroxychalcone 15.08 µM 0.563641972066684 0.291064544261339 no 1027 0.286498908107346 1408 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_64 000l-0018 272.079 µM 0.563516044182646 0.291103833882859 no 1028 0.2865417690169 1406 6811119
SGTC_96 0929-0093 37.281 µM 0.556656070898854 0.293247884952195 no 1029 0.288881218112461 1365 6991579
SGTC_2706 st078239 82.5 µM 0.556605677280085 0.293263662281629 no 1030 0.288898437002806 1385 15434492
SGTC_846 0335-0850 148 µM 0.556103766776551 0.293420822841626 no 1031 0.289069960110312 1378 6819598
SGTC_815 1582-0027 36.9 µM 0.556030716582234 0.293443699911825 no 1032 0.289094928306843 1442 3128206
SGTC_3212 9128307 49.47 µM 0.555761445599432 0.293528034422776 no 1033 0.289186972560718 1336 27243542
SGTC_2406 ethylparaben 405.7 µM 0.555388101124875 0.293644982869116 no 1034 0.289314614796315 1264 8434 A possible steroid mimic.
SGTC_1628 st004252 77.7 µM 0.553806693906823 0.294140590449088 no 1035 0.289855573331932 1498 692968
SGTC_980 1473-0395 201 µM 0.553802358516685 0.294141949676581 no 1036 0.28985705700875 1357 768876
SGTC_51 1013-0126 23.419 µM 0.552072552859893 0.294684508193637 no 1037 0.290449322979765 1520 1627850
SGTC_646 4092-0839 27.3 µM 0.550372083764986 0.295218314667538 no 1038 0.291032096006458 1483 877796
SGTC_1058 3448-5425 97.3 µM 0.550217777964671 0.295266775931374 no 1039 0.291085005646858 1333 7279705
SGTC_1039 k821-0043 94 µM 0.54875894494447 0.295725117709085 no 1040 0.291585444174374 1454 15992768
SGTC_1351 1496-0003 46.5 µM 0.547716244772926 0.296052917478753 no 1041 0.291943378009493 1422 3891978
SGTC_1267 0828-0272 9.49 µM 0.547374042777518 0.296160533863028 no 1042 0.292060892284274 1502 745334
SGTC_2861 9024595 19.48 µM 0.546160856001394 0.296542203849051 no 1043 0.292477685401823 1381 16482810
SGTC_2380 9035439 200 µM 0.544975057463907 0.296915475098969 no 1044 0.292885336201938 1498 6462575
SGTC_1817 st052116 64.4 µM 0.543246897183942 0.297459858152666 no 1045 0.293479910510114 1452 4361398
SGTC_2153 5569715 200 µM 0.542543835928652 0.297681457918965 no 1046 0.293721958929172 1438 2054701
SGTC_3134 9127454 49.47 µM 0.542205506727064 0.297788123649247 no 1047 0.293838471096957 1483 24262820
SGTC_1532 4',5'-dihydroxyflavone 78.7 µM 0.540537296006411 0.298314318520609 no 1048 0.294413273763907 1417 165521
SGTC_718 1130-0073 349 µM 0.538851341250862 0.298846539951762 no 1049 0.294994717207025 1494 6740020
SGTC_2261 9010538 184.68 µM 0.538058572385812 0.299096949911894 no 1050 0.295268306017643 1355 6457250
SGTC_2403 6032726 181.2 µM 0.536968928112039 0.299441288526161 no 1051 0.295644538585377 1439 2881040
SGTC_442 cape 100 µM 0.534649990209566 0.300174693951969 no 1052 0.296445954437045 1514 5281787
SGTC_2873 9040596 71.43 µM 0.534430159860952 0.300244261346143 no 1053 0.296521978584968 1414 6463863
SGTC_2059 5238311 157 µM 0.534117741381223 0.300343141668139 no 1054 0.296630037945103 1406 703021
SGTC_1305 1181-0477 144 µM 0.533369779172298 0.300579931171507 no 1055 0.296888816501966 1504 6252086
SGTC_1896 st058441 89 µM 0.533360415190522 0.300582896150355 no 1056 0.296892056889419 1372 688759
SGTC_257 daunorubicin 18.5 µM 0.532446286249006 0.300872406323894 no 1057 0.297208467283564 1555 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_37 0566-0070 1.56 µM 0.531740243436039 0.301096100403417 no 1058 0.29745295760131 1496 1626686
SGTC_1924 st058459 75.1 µM 0.531416558784503 0.301198677790283 no 1059 0.29756507465071 1413 688683
SGTC_2801 7907800 81.82 µM 0.53084543751634 0.301379707538703 no 1060 0.297762945185892 1443 6620925
SGTC_3339 9145883 14.936 µM 0.53063713147052 0.301445747019714 no 1061 0.29783512978269 1439 2030670
SGTC_1003 4049-0218 100 µM 0.530364626877914 0.301532149263971 no 1062 0.29792957324195 1502 295161
SGTC_363 0455-0021 3.06 µM 0.528235627044703 0.302207568317049 no 1063 0.298667902301369 1463 4597466
SGTC_1196 1588-0294 184 µM 0.527813873634263 0.302341448906704 no 1064 0.298814263451853 1404 6144269
SGTC_1746 st038117 42 µM 0.527213099587907 0.302532203389177 no 1065 0.299022806423223 1468 2898218
SGTC_1452 4194-0072 190 µM 0.525589565584478 0.303047968686423 no 1066 0.299586704061027 1544 1343545
SGTC_3099 9120367 49.47 µM 0.524997990200848 0.303235998463386 no 1067 0.299792294041614 1435 24824940
SGTC_3154 9100113 49.47 µM 0.524945321969532 0.30325274137016 no 1068 0.299810600909785 1400 25237525
SGTC_2511 berberine 10.47 µM 0.52434219505857 0.303444501161817 no 1069 0.300020276926038 1441 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_2882 9058044 58.44 µM 0.524170085093062 0.303499232200184 no 1070 0.300080122819904 1367 18076804
SGTC_2288 7946289 167.31 µM 0.521864467417535 0.304232844275556 no 1071 0.300882349861307 1574 1246052
SGTC_338 4055-0136 114 µM 0.521293405143941 0.304414669479701 no 1072 0.301081197207901 1407 2900563
SGTC_1916 st067606 49.2 µM 0.519566340431583 0.304964857891605 no 1073 0.301682931695996 1545 19590279
SGTC_1531 st059297 52.4 µM 0.519051719275767 0.305128885358109 no 1074 0.301862337721256 1474 7566702
SGTC_2629 bisabolol 100 µM 0.516718181465521 0.305873155029644 no 1075 0.302676451113115 1512 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer.
SGTC_3087 9117406 49.47 µM 0.515420353360429 0.306287437965961 no 1076 0.303129656370116 1432 42546093
SGTC_3283 9109332 35.8195 µM 0.514168492522082 0.306687282384429 no 1077 0.303567097074536 1411 17027281
SGTC_1447 4239-0816 81.9 µM 0.513132579187806 0.307018327223373 no 1078 0.303929291720204 1409 1341554
SGTC_685 1278-0033 54.9 µM 0.512575364757234 0.307196460288063 no 1079 0.304124194720207 1536 3590572
SGTC_2833 9001315 45.46 µM 0.511653701286468 0.307491202094391 no 1080 0.30444669724047 1499 2989378
SGTC_1169 aniline yellow 25.8 µM 0.511122118312352 0.30766125532205 no 1081 0.304632774499698 1504 6051 A DNA damaging agent.
SGTC_2654 protoveratrine a 100 µM 0.510274851780565 0.307932381054246 no 1082 0.304929459299748 1462 5702278 A heart drug and vasodilator.
SGTC_1435 4092-0789 56.7 µM 0.508696507783551 0.308437731552268 no 1083 0.305482485309436 1536 2248285
SGTC_1117 retinoic acid 1.10837 µM 0.50835685518172 0.308546528246434 no 1084 0.305601552160174 1575 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR).
SGTC_84 0443-0269 128.823 µM 0.507679656966233 0.308763496897119 no 1085 0.305839008599547 1442 6150058
SGTC_1430 4049-0248 69.1 µM 0.507162764301554 0.308929149923628 no 1086 0.30602030958571 1555 22774488
SGTC_1626 st003712 1.76 µM 0.50617521458637 0.309245746508923 no 1087 0.306366826469517 1509 24207035
SGTC_892 0929-0076 29 µM 0.505646926610627 0.309415167481182 no 1088 0.306552266212961 1462 5751038
SGTC_1247 0448-0043 5.84 µM 0.502875381724321 0.310304660016822 no 1089 0.307525945267667 1482 3089013 YGL099W LSG1
SGTC_2112 5488546 200 µM 0.502147826793543 0.310538343915585 no 1090 0.307781769853115 1442 600757
SGTC_1063 disulfiram 1.84 µM 0.495647408773847 0.312629603186297 no 1091 0.310071599015984 1475 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_1371 2421-0008 32.7 µM 0.495477269237987 0.312684420521542 no 1092 0.310131631712127 1498 2827552
SGTC_2365 9042475 200 µM 0.49437973469579 0.313038135213023 no 1093 0.310519011639469 1466 6464479
SGTC_129 0088-0017 176.636 µM 0.492981612590125 0.313488972909167 no 1094 0.31101278980738 1529 182446
SGTC_3325 9138760 55.175 µM 0.492109621405666 0.313770295920676 no 1095 0.311320925474816 1450 43844959
SGTC_1704 st028805 70.8 µM 0.488023540656886 0.315089993763581 no 1096 0.312766583458257 1483 2876101
SGTC_1694 st024011 44.9 µM 0.4875962268889 0.315228141805498 no 1097 0.312917934328098 1531 2787533
SGTC_2303 7774051 200 µM 0.486795309008966 0.315487143471019 no 1098 0.313201697505568 1581 2953184
SGTC_1187 1391-0724 117 µM 0.486049933684451 0.315728265194763 no 1099 0.313465881510478 1521 6997986
SGTC_1636 st007707 68.9 µM 0.483359608508141 0.31659921142113 no 1100 0.314420211227616 1600 403051
SGTC_900 1112-0045 141 µM 0.48329436409055 0.316620345832531 no 1101 0.314443370598008 1425 56211 YIL048W NEO1
SGTC_232 clozapine 119 µM 0.482460935506777 0.316890368284292 no 1102 0.314739271334517 1515 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_2378 9074213 121.43 µM 0.482314960837104 0.316937672649003 no 1103 0.314791110477042 1476 657714
SGTC_3137 9097352 49.47 µM 0.482132776166423 0.316996715378331 no 1104 0.314855813788555 1578 44120435
SGTC_1335 1486-0900 202 µM 0.481790005840174 0.317107813620821 no 1105 0.314977564875784 1486 X1335
SGTC_850 0388-0143 75.9 µM 0.481154172751375 0.3173139426113 no 1106 0.315203464296102 1480 67273
SGTC_1166 k206-0078 225 µM 0.480475196693409 0.31753412058027 no 1107 0.315444767907203 1474 5404595
SGTC_1801 st050089 28.441 µM 0.480254075817367 0.317605839472719 no 1108 0.315523369807485 1504 5008493 YIL048W | YNL267W NEO1 | PIK1
SGTC_1289 0976-0073 69.1 µM 0.4798796183672 0.317727307540517 no 1109 0.315656497338986 1543 3391136
SGTC_875 0709-0210 25.7 µM 0.47943873831251 0.317870347199066 no 1110 0.315813270174576 1545 6251364
SGTC_813 k007-0158 173 µM 0.478914810269279 0.318040366389955 no 1111 0.31599961719195 1616 6523916
SGTC_1074 carmofur 3.8 µM 0.477337264644239 0.31855252511216 no 1112 0.316560989675828 1523 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_2461 5755302 26.15 µM 0.475549346759311 0.319133401683867 no 1113 0.317197734688328 1622 2788904
SGTC_1349 flufenamic acid 69 µM 0.475373230056764 0.319190644296649 no 1114 0.317260485819554 1483 3371 A non-steroidal anti-inflammatory.
SGTC_529 4076-0302 30.3 µM 0.474782973396478 0.319382524841314 no 1115 0.317470835084149 1494 5816522
SGTC_2466 5983409 37.09 µM 0.473888357065898 0.319673438801376 no 1116 0.317789761123629 1508 2879657
SGTC_2521 angolensin 13.4 µM 0.473370647695851 0.319841839760265 no 1117 0.317974383592002 1553 821428 A flavenoid.
SGTC_2562 3',7'-dimethoxyflavone 64.92 µM 0.47291135159682 0.319991271090495 no 1118 0.318138212944935 1538 688664
SGTC_465 cgp-37157 41 µM 0.472588677290331 0.320096270186643 no 1119 0.318253331055628 1548 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange.
SGTC_710 3448-4187 58 µM 0.47191699152536 0.32031488477186 no 1120 0.318493019684639 1534 3946412
SGTC_2717 st081029 62.2815 µM 0.471738505696227 0.320372987318473 no 1121 0.318556724487829 1531 5292846
SGTC_447 ml7 120 µM 0.47119234384282 0.320550806901971 no 1122 0.31875169279156 1601 4216 Selective myosin light chain kinase inhibitor.
SGTC_641 4092-0595 30 µM 0.469835787591293 0.320992653169726 no 1123 0.319236171877174 1557 786260
SGTC_1673 st016611 27.3 µM 0.46748818106919 0.321757895074997 no 1124 0.320075323028443 1608 5226799
SGTC_2210 7115885 190.385 µM 0.466477926391503 0.322087437698445 no 1125 0.320436722017726 1519 2927039
SGTC_1299 1079-1439 3.74 µM 0.465377927254945 0.32244641387746 no 1126 0.320830419059757 1473 323161
SGTC_1508 1080-0625 72.9 µM 0.464787724607073 0.322639090220448 no 1127 0.321041739654525 1516 767111
SGTC_1927 st060202 13.8 µM 0.463521591423718 0.323052590110043 no 1128 0.321495271023683 1594 688887
SGTC_2727 riluzole 51.77 µM 0.462715974157048 0.323315806412687 no 1129 0.321783983331191 1534 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.
SGTC_2240 6690706 185.951 µM 0.461790713587493 0.323618222467336 no 1130 0.322115705492971 1454 805876
SGTC_125 0133-0007 11.75 µM 0.461666160990974 0.323658940664254 no 1131 0.322160370617271 1696 26541
SGTC_3153 9100258 49.47 µM 0.459888081083047 0.324240452861413 no 1132 0.322798277896902 1492 25236848
SGTC_624 k048-0052 28 µM 0.456759083159295 0.325264817166588 no 1133 0.323922109243517 1534 6835531
SGTC_2656 pseudo-anisatin 100 µM 0.45639190172008 0.325385111000732 no 1134 0.324054094072346 1570 6708809 A neurotoxin.
SGTC_184 1494-0393 24.714 µM 0.45633018162715 0.325405333162879 no 1135 0.324076281777191 1496 3090647
SGTC_2495 cafestol 54.53 µM 0.456298077213947 0.325415852155355 no 1136 0.324087823213052 1578 16667697 An anti-infammatory.
SGTC_1992 st073643 23.3 µM 0.455605578415879 0.325642782829232 no 1137 0.324336815499719 1556 3161292
SGTC_562 3772-2733 112 µM 0.454940850067608 0.325860673975162 no 1138 0.324575896656104 1568 2876874 YIL048W NEO1
SGTC_2690 usnic acid 100 µM 0.454077579614761 0.3261437339809 no 1139 0.324886494869255 1688 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_613 3914-0030 117 µM 0.451724656022295 0.326915748578205 no 1140 0.325733676818747 1495 1145395
SGTC_494 Boc-Gly-Val-Val-CHO 140 µM 0.448875244015745 0.32785165781703 no 1141 0.326760827699372 1548 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA.
SGTC_3254 9136651 49.47 µM 0.446199511155732 0.328731506537318 no 1142 0.327726568005883 1522 16454030
SGTC_910 3454-3003 490 µM 0.445498073507846 0.328962314389754 no 1143 0.327979925849022 1564 820824
SGTC_1469 k284-2957 126 µM 0.44350623326006 0.329618084219824 no 1144 0.328699805819181 1598 23884841
SGTC_531 3788-1495 174 µM 0.442062234417618 0.330093817168629 no 1145 0.329222085888833 1547 2896655
SGTC_235 0330-0087 5 mM 0.441376414018652 0.330319860597335 no 1146 0.329470257194083 1544 46494818 YHR062C RPP1
SGTC_755 1995-0008 37.3 µM 0.441112059070307 0.330407007383501 no 1147 0.329565936872362 1563 689533
SGTC_645 0845-0943 5.41 µM 0.439129839377053 0.331060755221345 no 1148 0.330283729467632 1556 1885106
SGTC_730 1436-0052 41.2 µM 0.438673596783681 0.331211299776616 no 1149 0.330449030586213 1574 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2
SGTC_2748 diazoxide 86.69 µM 0.438623891612234 0.331227702443131 no 1150 0.3304670412513 1607 3019 A potassium channel activatior.
SGTC_1123 mangostin 811.285 nM 0.438159084468942 0.331381104095083 no 1151 0.330635483084238 1540 5281650 An antioxidant.
SGTC_3069 9117009 49.47 µM 0.43662934051333 0.331886169621985 no 1152 0.331190090325871 1540 41904981
SGTC_2926 9010726 65.15 µM 0.434026538244194 0.332746221892847 no 1153 0.332134584926272 1530 2994293
SGTC_3241 9133421 49.47 µM 0.432808102354321 0.333149136554884 no 1154 0.3325770932998 1598 17018221
SGTC_58 0957-0393 9 µM 0.431012043222694 0.333743411968152 no 1155 0.333229806855684 1546 6997992
SGTC_1019 4262-0212 3.4 µM 0.430008756225665 0.334075558750833 no 1156 0.333594635843091 1597 4677213
SGTC_1667 st014849 34.6 µM 0.423516829916552 0.336227899033225 no 1157 0.335959111028393 1604 5348460
SGTC_1904 st060225 78 µM 0.422775475916854 0.336474031882546 no 1158 0.336229541048263 1555 66595
SGTC_2039 Aminomethylbenzodioxan 200 µM 0.422137324452813 0.336685957165524 no 1159 0.336462392896639 1575 15053
SGTC_1571 st070080 73.4 µM 0.421564471202688 0.33687624159191 no 1160 0.336671471848657 1696 4315245
SGTC_2306 7482397 179.52 µM 0.420983416879875 0.337069292826543 no 1161 0.336883595600306 1721 891448
SGTC_1985 st071382 65.5 µM 0.420673019338936 0.337172437829279 no 1162 0.336996932765053 1592 6123237
SGTC_8 0354-0001 70 µM 0.420332927351521 0.337285464340631 no 1163 0.337121129417942 1616 4993152
SGTC_2084 5306078 60.6385 µM 0.420258084725663 0.337310339585725 no 1164 0.337148463241609 1636 679340
SGTC_350 k064-0020 19.8 µM 0.4190060465737 0.337726581572214 no 1165 0.337605856664309 1691 2790705
SGTC_3239 9133757 49.47 µM 0.418678189018861 0.337835611140642 no 1166 0.337725668962126 1646 17036923
SGTC_166 k072-0058 166.424 µM 0.417864773261818 0.338106172633872 no 1167 0.338022994698476 1630 5846229
SGTC_3157 9099274 49.47 µM 0.416524116226439 0.338552289639359 no 1168 0.338513262070883 1682 17217662
SGTC_1397 3532-0190 20.1 µM 0.415727751044915 0.338817395446446 no 1169 0.338804616035145 1620 5322280
SGTC_21 0849-0113 22.993 µM 0.415271789271616 0.338969218699234 no 1170 0.338971475245594 1570 1560156
SGTC_62 0180-0423 3.232 µM 0.413777961726794 0.339466807028075 no 1171 0.339518362618048 1617 30102 YGL099W LSG1
SGTC_1303 1160-0052 261 µM 0.413740456879738 0.339479303358014 no 1172 0.339532097425553 1611 3562476
SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM 0.411914881371506 0.340087784393324 no 1173 0.340200906461712 1597 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding.
SGTC_1785 bathophenanthroline 24 µM 0.41077278312176 0.34046866822321 no 1174 0.340619576020825 1549 72812 An iron chelator.
SGTC_1500 4488-1866 171 µM 0.410466370238699 0.340570883036315 no 1175 0.340731934079986 1699 2900003
SGTC_567 1080-0542 68.4 µM 0.408497713304996 0.341227876948814 no 1176 0.34145415450551 1681 5950415
SGTC_2133 5320837 200 µM 0.407291764411873 0.341630572616548 no 1177 0.341896855398331 1668 2841355
SGTC_2740 felodipine 17.08 µM 0.406992745413024 0.341730450249046 no 1178 0.342006658213575 1721 3333 L-type calcium channel blocker
SGTC_998 3996-0085 177 µM 0.406807779095264 0.341792237816971 no 1179 0.342074586415698 1752 715391
SGTC_1962 st076595 64.5 µM 0.406318170432866 0.34195581090538 no 1180 0.342254418069405 1619 279619
SGTC_1223 0764-0573 147 µM 0.404984756804288 0.342401440686374 no 1181 0.342744357817753 1602 1609797
SGTC_2863 9028737 58.44 µM 0.404613210131676 0.342525651534293 no 1182 0.342880923384616 1727 6460917
SGTC_102 gallobenzophenone 83.616 µM 0.403727057960988 0.342821967602833 no 1183 0.343206720022604 1712 70837
SGTC_1573 oleylamine 1.06 µM 0.403571026033883 0.34287415237138 no 1184 0.34326409772906 1591 5356789 An amine of the fatty acid oleic acid.
SGTC_1436 4092-1007 8.32 µM 0.403107361090145 0.343029242473655 no 1185 0.343434622811014 1612 2881121
SGTC_3193 9111931 49.47 µM 0.402739559052139 0.343152286450816 no 1186 0.343569914439285 1638 17087244
SGTC_3164 9100705 49.47 µM 0.402456892520683 0.34324686061842 no 1187 0.343673903599717 1698 17174235
SGTC_436 n,n-dimethylsphingosine 3.3 µM 0.401447589778072 0.343584631779583 no 1188 0.344045308798531 1694 5282309
SGTC_2449 5812982 45.77 µM 0.401064559009354 0.343712848778194 no 1189 0.34418629662719 1623 776185
SGTC_1923 st058458 19.1 µM 0.398876311513853 0.344445694443913 no 1190 0.344992172234106 1744 3534982
SGTC_1821 st053465 65.6 µM 0.398852000252743 0.34445383958977 no 1191 0.345001129408527 1597 675086
SGTC_1933 st074711 15.9 µM 0.398391843839325 0.344608022119029 no 1192 0.345170684551614 1585 17250958
SGTC_2456 5770359 74.46 µM 0.398369624691858 0.34461546764195 no 1193 0.345178872491105 1708 3118787
SGTC_2267 7931562 200 µM 0.397310217131996 0.344970539520367 no 1194 0.34556935698149 1526 934880
SGTC_34 0469-0683 81.75 µM 0.396453065505589 0.345257923100595 no 1195 0.34588541277265 1694 3690923
SGTC_2953 9074162 66.49 µM 0.396243779048865 0.345328105684876 no 1196 0.345962598869578 1785 16451992
SGTC_2721 ifenprodil 61.44 µM 0.395403059966071 0.345610087861673 no 1197 0.34627272557118 1714 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor.
SGTC_1488 4013-0813 75.9 µM 0.395187977593626 0.345682241538556 no 1198 0.346352082302489 1611 2910057
SGTC_962 1254-0300 21.5 µM 0.394952845506932 0.345761127706724 no 1199 0.346438844288547 1651 7340576
SGTC_2115 tiliquinol 12.7705 µM 0.391595247088203 0.346888321863494 no 1200 0.347678650137653 1647 71208 A bioactive hydroxyquinoline.
SGTC_1009 4106-0057 9.87 µM 0.387537934132478 0.348252229679566 no 1201 0.34917900362963 1718 2928005
SGTC_783 0848-0141 92.7 µM 0.387249459147512 0.348349278557464 no 1202 0.349285768922514 1618 6755076 YHR007C | YLR033W ERG11 | RSC58
SGTC_1759 st043059 70 µM 0.38704901219528 0.348416718854075 no 1203 0.349359961850419 1584 669426
SGTC_1256 0570-0116 285 µM 0.385846826441444 0.348821294261474 no 1204 0.349805056546119 1589 410638
SGTC_138 0850-0259 40.9225 µM 0.384021961401236 0.349435750421584 no 1205 0.350481085169549 1636 6813004
SGTC_2012 4023501 200 µM 0.38319865879457 0.349713096608734 no 1206 0.350786236197641 1609 3477460
SGTC_2034 5197015 53.07 µM 0.38205678023013 0.350097894342543 no 1207 0.351209624395338 1750 780676
SGTC_2784 7567673 72.73 µM 0.378090171413764 0.351435782387413 no 1208 0.352681804710676 1627 3471247
SGTC_945 3381-0768 11.3 µM 0.375935105387209 0.352163433144171 no 1209 0.353482570636457 1704 1126236 YIL048W NEO1
SGTC_1969 st069479 40.1 µM 0.375726452657966 0.352233912831383 no 1210 0.353560135021441 1739 3895485
SGTC_1239 0337-0584 35.4 µM 0.374226318015412 0.352740784560433 no 1211 0.354117972624567 1799 914301 YML130C ERO1
SGTC_1509 1326-1131 80 µM 0.373906518311337 0.352848873661964 no 1212 0.35423693336134 1772 768313
SGTC_1002 4049-0206 172 µM 0.37297019669032 0.35316540927596 no 1213 0.35458531284697 1622 4662749
SGTC_2937 9044753 11.33 µM 0.371713867246425 0.353590287290188 no 1214 0.355052949552623 1625 6465530 YGL099W LSG1
SGTC_1607 st000305 50.6 µM 0.3716270996185 0.353619637973732 no 1215 0.355085254668189 1718 5457690
SGTC_576 1073-0113 22.7 µM 0.370049829558246 0.354153328986467 no 1216 0.355672681452412 1735 5439563
SGTC_856 0433-0016 11.3 µM 0.368064013918315 0.354825664507745 no 1217 0.356412751491826 1672 3911780
SGTC_389 tpck 16.7 µM 0.367890693738896 0.354884366835038 no 1218 0.356477369842157 1680 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.
SGTC_1154 4088-0362 150 µM 0.367666154874292 0.354960421694135 no 1219 0.356561090000487 1640 6618304
SGTC_1214 0358-0031 63.7 µM 0.366955014984156 0.355201334132042 no 1220 0.356826286770119 1847 4301366
SGTC_1554 st069299 38.7 µM 0.366754076301792 0.355269416503204 no 1221 0.356901232941067 1732 24207999
SGTC_2852 9023854 51.95 µM 0.366738096500923 0.355274831003656 no 1222 0.356907193329188 1738 19798528
SGTC_178 4092-0806 87.505 µM 0.366324426114175 0.355415006776047 no 1223 0.357061502526966 1645 2169044
SGTC_1497 4476-2978 41.3 µM 0.366159269691785 0.355470976916899 no 1224 0.357123116455624 1688 1528379
SGTC_253 dyclonine 31.25 µM 0.365950660135481 0.355541677419166 no 1225 0.357200946513118 1744 3180 An oral anasthetic.
SGTC_1984 st072354 53.1 µM 0.364580928592012 0.356006020693235 no 1226 0.357712126572449 1710 5762938
SGTC_2501 sodium tetradecyl sulfate 13.37 µM 0.363965806607398 0.356214618533389 no 1227 0.357941771542315 1627 23665772 A membrane-active detergent.
SGTC_181 1447-1644 8.07 µM 0.36246706486023 0.35672304622945 no 1228 0.358501515519621 1792 534600
SGTC_2714 st079313 56.9 µM 0.362296691112206 0.356780859336153 no 1229 0.358565165288548 1675 2939799
SGTC_1359 1582-0056 520 nM 0.361968364183374 0.356892280142979 no 1230 0.358687835718173 1727 3661189
SGTC_2083 5306046 65.942 µM 0.35913709822713 0.357853602342094 no 1231 0.359746264985875 1666 539837
SGTC_908 3448-7491 47.7 µM 0.358717634446353 0.357996103089793 no 1232 0.359903167426735 1638 1203031
SGTC_1699 st031318 29.054 µM 0.350879158961654 0.360662619952856 no 1233 0.362839503703313 1758 5340658
SGTC_149 3970-0822 46.1 µM 0.349299418541471 0.361200847122255 no 1234 0.363432267465386 1700 3114250 YBL034C STU1
SGTC_295 k015-0027 31 µM 0.348647248424016 0.361423125674675 no 1235 0.363677075825716 1721 3887424
SGTC_2865 9030313 51.95 µM 0.348638835039059 0.361425993506887 no 1236 0.363680234364044 1641 42562754
SGTC_2620 irigenin 100 µM 0.347818615562496 0.361705615340818 no 1237 0.363988204180112 1799 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro.
SGTC_1253 0550-0034 176 µM 0.347592070483896 0.361782860071622 no 1238 0.364073281110433 1697 5969915
SGTC_40 0327-0103 19.753 µM 0.346180199271597 0.362264390460014 no 1239 0.364603647252925 1662 409036
SGTC_789 1309-1135 70.6 µM 0.345403037074993 0.362529541164291 no 1240 0.36489569712979 1640 3092424
SGTC_2199 6590217 200 µM 0.34477433560044 0.362744088586916 no 1241 0.365132014311353 1774 703109
SGTC_413 propylparaben 100 µM 0.341284434581008 0.363935816143848 no 1242 0.366444732333938 1666 7175 A pharmaceutical preservative.
SGTC_1127 asiatic acid 681.4 nM 0.340354082391021 0.364253734644811 no 1243 0.366794946813242 1664 470603 A kinase inhibitor which arrests cells at G2/M.
SGTC_35 0133-0054 64.071 µM 0.340105817104538 0.364338587272326 no 1244 0.366888420608573 1625 99677
SGTC_3037 9091026 49.47 µM 0.338890583140822 0.36475402833152 no 1245 0.367346079349106 1758 25236398 YIL048W NEO1
SGTC_2330 7979373 200 µM 0.337874436834987 0.365101531070114 no 1246 0.367728906156443 1596 1863007
SGTC_3252 9135871 49.47 µM 0.336743644643781 0.365488370789175 no 1247 0.368155079615954 1775 17682838
SGTC_2171 5739187 198.077 µM 0.336719849809758 0.365496512383276 no 1248 0.368164049168857 1659 2262761
SGTC_1284 0929-0043 16 µM 0.335665381196172 0.365857368112293 no 1249 0.368561607203905 1704 1239883
SGTC_867 0518-0118 155 µM 0.334507912332704 0.366253608815094 no 1250 0.368998160633608 1759 6848158
SGTC_1965 Pectolinarigenin 58.4 µM 0.330224320764822 0.367721264809146 no 1251 0.370615235660061 1709 5320438 An anti-inflammatory.
SGTC_2739 tacrine 100.86 µM 0.329147237927605 0.368090602990386 no 1252 0.371022200444158 1736 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders.
SGTC_990 3985-0011 41.3 µM 0.328961301794584 0.368154373962325 no 1253 0.371092469136301 1734 5399565 YGL099W LSG1
SGTC_2903 5923464 63.88 µM 0.32873660163043 0.368231444777324 no 1254 0.371177393205875 1823 2876576
SGTC_803 4488-1585 147 µM 0.328560859560665 0.368291726954157 no 1255 0.371243818231606 1812 747204
SGTC_1020 4335-0961 93.3 µM 0.328436298223948 0.368334455332398 no 1256 0.37129090085802 1657 669075
SGTC_1685 st024049 53.0905 µM 0.327065635533328 0.368804742332452 no 1257 0.371809121274622 1755 1941139
SGTC_1128 3448-9350 235 µM 0.326514111514462 0.368994030793331 no 1258 0.372017707192892 1710 619386
SGTC_1358 1509-0022 2.48 µM 0.325866758534917 0.369216249232114 no 1259 0.372262583462364 1779 3258434
SGTC_3121 9125696 49.47 µM 0.323885738711381 0.369896550015685 no 1260 0.373012270686871 1817 1235365
SGTC_807 1315-0151 48 µM 0.322520519646599 0.370365616279299 no 1261 0.373529197574358 1888 4011080
SGTC_2951 9072950 58.06 µM 0.322305844740605 0.370439392521109 no 1262 0.373610502870181 1826 16488155
SGTC_772 k072-0172 35.3 µM 0.322275826813746 0.370449709010412 no 1263 0.373621872213387 1648 5861980
SGTC_2463 5473429 200 µM 0.320551848231334 0.371042357963882 no 1264 0.374275016429308 1722 5399405
SGTC_1526 st051518 75 µM 0.320213884976855 0.371158574888096 no 1265 0.37440309911623 1735 673993
SGTC_785 1270-0111 65.3 µM 0.319161616425521 0.371520498350365 no 1266 0.374801980837113 1729 6741994
SGTC_1902 st060212 70.5 µM 0.317174244315276 0.372204356545007 no 1267 0.375555695903342 1733 688944
SGTC_2109 5483026 200 µM 0.314443698192114 0.373144599482628 no 1268 0.376592035792387 1765 759335
SGTC_136 0097-0015 404.482 µM 0.314405756900386 0.373157669617916 no 1269 0.376606442155944 1865 4861337
SGTC_1648 st011736 69.8 µM 0.311428501097336 0.374183738048809 no 1270 0.37773744484374 1843 2855514
SGTC_2693 st077581 40.7 µM 0.311110317662819 0.374293448278178 no 1271 0.377858378874302 1810 25238761
SGTC_3165 9101544 49.47 µM 0.310526409315952 0.374494807420038 no 1272 0.378080339822335 1833 5002184
SGTC_2387 9077560 195.08 µM 0.309502224983497 0.374848077142997 no 1273 0.378469759953859 1727 5303272
SGTC_1341 1486-1360 280 µM 0.309005026746959 0.375019612565815 no 1274 0.378658851518695 1734 3976547
SGTC_2992 9074591 71.4286 µM 0.307552085115883 0.375521024943182 no 1275 0.379211592246325 1808 17741321
SGTC_3095 9117207 49.47 µM 0.305284237259529 0.376304082812267 no 1276 0.380074840063563 1904 17015229
SGTC_1588 farnesol 29.9 µM 0.304725060862761 0.376497237438889 no 1277 0.380287780506951 1751 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_1842 st055362 61.2 µM 0.304716150889735 0.37650031543462 no 1278 0.380291173815291 1829 676032
SGTC_1417 3966-0327 90.4 µM 0.304214211614962 0.376673725599108 no 1279 0.380482349167212 1788 651118
SGTC_1943 st076331 65.2 µM 0.303861827972349 0.376795482100357 no 1280 0.380616580191759 1930 24208415
SGTC_1864 st057645 30.4 µM 0.302724526798299 0.377188528869651 no 1281 0.381049902315275 1871 688666
SGTC_1286 0929-0070 131 µM 0.302299781592112 0.377335351789135 no 1282 0.381211772410551 1846 1420408
SGTC_477 mead ethanolamide 10 µM 0.300895174725579 0.377821012529183 no 1283 0.381747214962558 1781 16061185
SGTC_2332 7982454 138.89 µM 0.299810586964974 0.378196154807685 no 1284 0.382160819686777 1788 2981748
SGTC_1030 k029-0042 36.7 µM 0.294635929503496 0.379987565123127 no 1285 0.384136006065694 1794 6080581
SGTC_139 0099-0334 718.624 µM 0.293672886320926 0.380321245929877 no 1286 0.384503937380483 1909 97690
SGTC_2472 5377652 49.4 µM 0.293138459785587 0.380506455596143 no 1287 0.384708160330001 1766 1610903
SGTC_233 rapamycin 362 pM 0.292365906128576 0.380774238478141 no 1288 0.385003436470805 1876 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C
SGTC_3111 9122088 49.47 µM 0.290626518478879 0.381377354688594 no 1289 0.385668488139789 1891 16876704
SGTC_793 0488-0545 106 µM 0.290164529124914 0.381537593622439 no 1290 0.385845185515222 1753 292548
SGTC_2417 cerulenin 830 nM 0.28915815066407 0.381886721734406 no 1291 0.386230177711917 1784 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1
SGTC_1037 k284-1091 78.7 µM 0.28891102850972 0.381972466902159 no 1292 0.386324731960973 1754 3334711
SGTC_2961 9083290 32.55 µM 0.287772270494942 0.382367662025346 no 1293 0.38676053240902 1810 17741490
SGTC_2870 9038528 12.99 µM 0.284789412375533 0.383403414520474 no 1294 0.387902742095447 1796 6463316
SGTC_32 0928-0142 34.1 µM 0.283168992772827 0.3839664308177 no 1295 0.388523648082689 1893 2244242
SGTC_1655 st012546 55.1 µM 0.280273515926602 0.384973076233301 no 1296 0.389633834032674 1837 720985 YLR208W SEC13
SGTC_3196 9111891 49.47 µM 0.280085369707294 0.385038514318604 no 1297 0.389706004478763 1824 18891510
SGTC_2246 7293507 91.5585 µM 0.27845171998352 0.385606842354262 no 1298 0.39033281092156 1961 887656
SGTC_2815 7968870 71.43 µM 0.277722768974782 0.385860515411388 no 1299 0.390612590399749 1774 2977326 YHR190W ERG9
SGTC_2738 aclarubicin 5.55 µM 0.277651726106185 0.385885240757472 no 1300 0.390639860471849 1881 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31
SGTC_871 0574-0004 149 µM 0.276244855145561 0.386374975301041 no 1301 0.39118000381429 1822 9551173
SGTC_359 0081-0058 15.9 µM 0.275345105779394 0.38668827479895 no 1302 0.391525556886925 1941 3494159
SGTC_1103 duloxetine 36.1 µM 0.273068889243278 0.387481199894748 no 1303 0.392400130491052 1910 60835 A selective serotonin reuptake inhibitor.
SGTC_289 k017-0060 526 µM 0.270587217262725 0.388346230875636 no 1304 0.393354264165483 1833 5512909
SGTC_3243 9134147 49.47 µM 0.26984913826946 0.388603608562016 no 1305 0.39363815885839 1946 24282180
SGTC_3355 9151058 44.0485 µM 0.269662880654583 0.388668566733554 no 1306 0.393709809926021 1902 17015728
SGTC_2604 4'-hydroxychalcone 11.32 µM 0.268552835146775 0.38905576454747 no 1307 0.39413690566069 1789 5282362
SGTC_196 k015-0023 18.111 µM 0.26740293868384 0.389456979089373 no 1308 0.394579468527743 1825 5211998
SGTC_680 0417-1641 114 µM 0.263687088835948 0.390754293491079 no 1309 0.396010522574093 1806 2835990
SGTC_271 rotenone 740 µM 0.26258640421825 0.391138809709017 no 1310 0.396434690144779 1918 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria.
SGTC_1917 st066507 28.5 µM 0.260228351464336 0.391962936205521 no 1311 0.397343818051287 1798 3156428
SGTC_1006 4099-6547 255 µM 0.258630999059925 0.392521477864405 no 1312 0.397959981507797 1905 3146833
SGTC_2078 5212016 200 µM 0.256381697594287 0.39330835992857 no 1313 0.398828059442829 1992 1899708
SGTC_225 nsc-122657 1.016 µM 0.256118206658793 0.393400566601489 no 1314 0.398929781932105 1906 275685
SGTC_3071 9117417 49.47 µM 0.255392673045343 0.39365449252181 no 1315 0.399209914634064 1988 45595590 YGL055W OLE1
SGTC_1831 st055328 12 µM 0.25500295067939 0.393790908204861 no 1316 0.399360410121923 1960 1103068
SGTC_2680 butyl paraben 22.24 µM 0.252909716072507 0.39452383199089 no 1317 0.400168990583577 1932 7184 An antifungal and steroid mimetic.
SGTC_794 k038-0031 316 µM 0.251957149273161 0.394857486932404 no 1318 0.400537092684379 1816 6624242
SGTC_2459 5811157 9.22 µM 0.250566871635457 0.395344596929699 no 1319 0.401074498671988 1991 2870684 YBR192W RIM2
SGTC_548 1436-0017 110 µM 0.250380285228449 0.395409983462761 no 1320 0.401146637137107 1968 9677137
SGTC_671 0560-0003 407 µM 0.250346513867691 0.39542181846704 no 1321 0.401159694258419 1914 3238678
SGTC_302 1094-0063 18.9 µM 0.250134634852431 0.395496072607411 no 1322 0.401241616188498 1847 5440289
SGTC_3163 9099914 49.47 µM 0.249301686610585 0.395788020548323 no 1323 0.401563713389155 1961 16268368
SGTC_1888 azatryptophan 97.5 µM 0.247050521061121 0.396577345093424 no 1324 0.40243456270664 1858 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides
SGTC_2816 7982706 58.44 µM 0.246511157724085 0.396766524757558 no 1325 0.402643284138825 1839 2981853
SGTC_2055 5235184 200 µM 0.245711843270151 0.397046925977399 no 1326 0.402952651806983 1872 2836034
SGTC_2030 5175110 200 µM 0.244048709156115 0.39763052742642 no 1327 0.40359654786044 1922 2831986
SGTC_3328 9140624 29.0385 µM 0.242997973599481 0.397999353616997 no 1328 0.404003483623491 1988 4904392
SGTC_206 4546-0025 72.014 µM 0.242802315691435 0.398068042975133 no 1329 0.404079270791615 1881 6620745 YIL048W NEO1
SGTC_1147 3809-1045 12.3 µM 0.242584313080788 0.398144580578928 no 1330 0.404163717315506 1857 325925
SGTC_258 haloperidol 50.781 µM 0.239262393481545 0.399311342351381 no 1331 0.405451062126307 1826 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_2439 5492030 7.2 µM 0.23850259380423 0.399578334535393 no 1332 0.405745651913662 1999 5722370
SGTC_1234 0326-0494 15.5 µM 0.238300833013255 0.399649240796535 no 1333 0.405823887653107 1978 1547813
SGTC_1501 4491-0275 38.4 µM 0.237799834544424 0.399825324637695 no 1334 0.406018173501722 2004 5104718
SGTC_1096 rimcazole 32.2 µM 0.237455245435282 0.39994644776133 no 1335 0.406151817663338 1872 18528119 A dopamine reuptake inhibitor.
SGTC_219 mitoxanthrone 164.414 µM 0.236627155459738 0.400237560855674 no 1336 0.406473025695686 1961 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA. YMR168C CEP3
SGTC_2853 9015042 58.44 µM 0.234666496272504 0.400927046757506 no 1337 0.407233796867019 1851 6457456
SGTC_1283 0922-0125 16.4 µM 0.234655255721597 0.400931000504511 no 1338 0.407238159415758 1953 3360884
SGTC_2082 5219693 150 µM 0.234218120826233 0.401084766029309 no 1339 0.407407823924871 1880 2834649
SGTC_3349 9149703 23.001 µM 0.232664836622156 0.401631269370614 no 1340 0.408010838109225 1944 4910494
SGTC_205 1486-1330 71.903 µM 0.232426542100682 0.401715127327667 no 1341 0.408103367849519 1906 4118834
SGTC_2217 6934799 96.0675 µM 0.230963389301721 0.40223012285305 no 1342 0.408671622099401 1987 675606
SGTC_1687 st020778 55.3625 µM 0.230289465973521 0.402467385242852 no 1343 0.40893342279812 1924 4259299
SGTC_2413 inermin 26.06 µM 0.228692680379488 0.403029695094238 no 1344 0.409553892126891 2036 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1
SGTC_364 0083-0097 67.7 µM 0.228623369069163 0.403054107701527 no 1345 0.409580829841143 1880 5207356
SGTC_1786 berberine 21.6 µM 0.228463160991245 0.403110537122662 no 1346 0.409643096051645 1847 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_460 trequinsin 123 µM 0.227166982741948 0.40356715867205 no 1347 0.410146950257654 1988 5537 A vasodilator.
SGTC_2196 6573537 42.6665 µM 0.223597390553362 0.404825343134943 no 1348 0.411535297151247 2025 2903087
SGTC_1231 0242-0792 125 µM 0.221357078689236 0.405615496065824 no 1349 0.412407204850018 1855 3707635
SGTC_2230 bromochlorosalicylanilide 954.5 nM 0.219450554632922 0.406288225971242 no 1350 0.413149546364045 2023 77254
SGTC_283 0987-0079 11.7 µM 0.218132520964946 0.406753464978438 no 1351 0.413662929689297 2015 411556
SGTC_1091 telmisartan 47.6 µM 0.218102764737283 0.406763969841891 no 1352 0.413674521655123 1994 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension.
SGTC_1989 st071868 50.2 µM 0.217199443918584 0.407082901767862 no 1353 0.41402645901472 2032 16414057
SGTC_630 4356-0227 183 µM 0.217160089409439 0.407096797911794 no 1354 0.414041793258764 1962 779312
SGTC_1731 st035964 63 µM 0.215058307416913 0.407839110170893 no 1355 0.414860929589717 1863 6739575
SGTC_762 1165-0429 115 µM 0.214212964595461 0.408137763795273 no 1356 0.415190493224707 2038 5967793
SGTC_818 4072-2707 53.5 µM 0.214043157032335 0.408197762046358 no 1357 0.415256701262123 1917 882871
SGTC_3279 9140807 49.47 µM 0.213841612520987 0.408268976733712 no 1358 0.415335286671444 2025 45595718
SGTC_172 1112-0046 2.638 µM 0.213479618628437 0.408396892968078 no 1359 0.415476442348306 1913 2802135 YIL048W NEO1
SGTC_3053 9095903 49.47 µM 0.212044222271081 0.408904208805863 no 1360 0.416036267141069 2049 17174018
SGTC_311 1315-0136 58 µM 0.212041225088857 0.408905268267705 no 1361 0.416037436263019 2008 6759207
SGTC_245 methotrexate 289.6 µM 0.211617837954769 0.409054936360318 no 1362 0.416202595908675 1980 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2
SGTC_2914 7968218 45.32 µM 0.210960175947821 0.409287447319177 no 1363 0.41645917348468 2005 2977111
SGTC_2922 7999257 32.47 µM 0.210910091667215 0.409305155510863 no 1364 0.416478714622004 1971 2988377
SGTC_145 3737-0113 38.366 µM 0.210659928054535 0.409393608092994 no 1365 0.416576322817353 2061 6849351
SGTC_367 0335-0881 7.1 µM 0.208856412775196 0.410031429329446 no 1366 0.417280165637616 2002 23828853
SGTC_949 1165-0505 146 µM 0.208015679281513 0.410328839959531 no 1367 0.417608362416318 1872 6244267
SGTC_2642 cholecalciferol 100 µM 0.207740827063719 0.410426080505523 no 1368 0.417715668821617 2016 9821465 A vitamin D precursor, similar to steriods.
SGTC_222 nsc-310342 10.666 µM 0.206880778130903 0.410730394582328 no 1369 0.418051484300497 2047 432556
SGTC_3155 9099265 49.47 µM 0.205983679690317 0.411047875278891 no 1370 0.418401829832718 1976 25236499
SGTC_2366 9070441 60.58 µM 0.203670763144447 0.41186667846435 no 1371 0.41930539545541 1923 6837235
SGTC_1067 clotrimazole 1.36 µM 0.202772315321778 0.412184844650007 no 1372 0.419656498786421 1925 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_1300 1094-0077 113 µM 0.202596733616802 0.412247029925559 no 1373 0.419725121628026 1911 5532636
SGTC_1504 k297-0033 30 µM 0.202287740731234 0.412356470410788 no 1374 0.419845891673385 1862 4388117
SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM 0.196930194772886 0.414255106429904 no 1375 0.421941082163107 1911 6708561
SGTC_520 3584-0023 682 µM 0.195459035905236 0.414776816489167 no 1376 0.422516801875063 1898 1340790
SGTC_3003 9075612 71.4286 µM 0.19540274890833 0.41479678027079 no 1377 0.422538832386972 1966 6501993
SGTC_2989 9073649 71.4286 µM 0.195119819637887 0.414897132501819 no 1378 0.422649573472924 2102 21367202
SGTC_2878 9043973 25.97 µM 0.194367398596269 0.415164035854902 no 1379 0.422944107627303 2055 6465167
SGTC_3253 9135987 49.47 µM 0.193034941963951 0.415636788945775 no 1380 0.423465801483429 2016 4182430
SGTC_2580 diallyl disulphide 81.36 µM 0.192743641143283 0.415740158218074 no 1381 0.423579871769765 1929 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.
SGTC_937 3122-0005 46.7 µM 0.191926749734712 0.416030066511319 no 1382 0.423899791844293 2079 759535
SGTC_3152 9099253 49.47 µM 0.189994037070946 0.416716152618968 no 1383 0.424656901577737 2029 25236131
SGTC_1747 st037496 66.6 µM 0.189699324868092 0.416820793700557 no 1384 0.424772374940597 1974 723305
SGTC_2176 5809774 33.9695 µM 0.187750447886553 0.41751291372139 no 1385 0.425536140858136 2097 2870539
SGTC_3039 9090270 49.47 µM 0.186702800909914 0.417885078620735 no 1386 0.425946829954624 2104 17173750
SGTC_2351 9026858 72.31 µM 0.185418845922988 0.41834128957924 no 1387 0.42645026389978 1958 1409300
SGTC_2993 9054257 71.4286 µM 0.185090639207626 0.418457924642674 no 1388 0.426578971792894 2027 6470217 YGL055W OLE1
SGTC_3293 9120939 62.045 µM 0.184269925987691 0.418749613466095 no 1389 0.426900852750052 2017 934087
SGTC_1543 azetidyl-2-carboxylic acid 198 µM 0.183541969435867 0.419008373132503 no 1390 0.427186395601798 2049 16486 A toxic proline analog.
SGTC_1944 st076371 56.9 µM 0.18222538571279 0.41947645532035 no 1391 0.427702925797672 1908 24208455
SGTC_221 trifluoperazine 10.304 µM 0.180083844463565 0.420238076069842 no 1392 0.428543372755853 2067 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1
SGTC_1176 0848-0131 83.3 µM 0.179183213412494 0.420558467173931 no 1393 0.42889692208381 2121 6769040
SGTC_513 4245-1575 41.7 µM 0.178857708693723 0.420674275404988 no 1394 0.429024715402138 2058 719745
SGTC_651 3253-0966 34.4 µM 0.178512079274889 0.420797251127301 no 1395 0.429160417832101 1984 781462
SGTC_2268 7933382 153.85 µM 0.177361888563773 0.421206547156093 no 1396 0.429612070599848 2118 935025 YOR257W CDC31
SGTC_2956 9076196 2.52 µM 0.177312444099644 0.421224143909563 no 1397 0.429631488344763 2109 16423868
SGTC_1789 tunicamycin 25 nM 0.176300972610996 0.421584150228358 no 1398 0.430028748984466 2107 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_3216 9129716 49.47 µM 0.175936375769604 0.421713934846188 no 1399 0.430171963664965 1981 8056934
SGTC_2103 5378138 10 µM 0.172804064822295 0.422829284604647 no 1400 0.431402720923764 2050 244142
SGTC_250 brefeldin a 552.239 µM 0.171361074193719 0.42334331186111 no 1401 0.431969930150126 2006 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.
SGTC_1720 st037298 9.481 µM 0.171194875922551 0.42340252399802 no 1402 0.432035268220494 1977 597396
SGTC_859 0439-0102 54.6 µM 0.170975329320743 0.423480745414369 no 1403 0.432121582144352 2130 610143
SGTC_3059 1327-0034 3 µM 0.170287002846586 0.4237260061482 no 1404 0.43239221610306 1969 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_619 1652-1634 108 µM 0.170246275050276 0.423740518981271 no 1405 0.432408230320504 1979 5400454
SGTC_1592 4',5'-dihydroxyflavone 8.85 µM 0.169493069738607 0.424008932755373 no 1406 0.432704411523685 1948 688669
SGTC_3132 9126706 49.47 µM 0.167999990671349 0.424541113539963 no 1407 0.433291643208858 2030 850858
SGTC_1373 2887-0003 58.5 µM 0.16543695453889 0.425454981290888 no 1408 0.434300034440663 2006 776948
SGTC_1385 3091-4834 14.1 µM 0.16360073226639 0.426109945301121 no 1409 0.435022734104037 2057 4072814
SGTC_3108 9121785 49.47 µM 0.163402016401681 0.426180837724575 no 1410 0.435100957681515 2136 17140271
SGTC_2148 5546263 113.568 µM 0.162772026558788 0.426405604067958 no 1411 0.435348967034542 2009 792097
SGTC_2733 amorolfine 100 µM 0.161455463675151 0.42687540147569 no 1412 0.435867342961549 2161 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_348 k064-0012 10.7 µM 0.160842883411768 0.427094027748158 no 1413 0.43610857442446 2056 5066323
SGTC_17 0960-0276 49.807 µM 0.160626564006369 0.427171236218406 no 1414 0.436193765755758 2107 6821114
SGTC_3036 9090181 49.47 µM 0.160470674806409 0.427226877739938 no 1415 0.436255160180847 2044 25236586
SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM 0.16042827887853 0.427242010366045 no 1416 0.436271857392966 2098 66535 A nucleotide analog.
SGTC_2575 plumbagin 510 nM 0.159720690528745 0.427494589795324 no 1417 0.43655055072916 1948 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_1060 3448-7350 82 µM 0.156128347000487 0.428777362447133 no 1418 0.437965927335533 2132 570178
SGTC_1762 st045503 25.4615 µM 0.155397322136902 0.42903849320831 no 1419 0.438254047573813 1996 4645554
SGTC_1836 st055642 81 µM 0.15470339665064 0.429286400370206 no 1420 0.438527576047909 1930 8571
SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM 0.154493209294368 0.429361496002725 no 1421 0.438610432569221 1991 442882
SGTC_1820 st053765 18.6 µM 0.152770939411978 0.429976923771015 no 1422 0.439289457835458 1998 3690829
SGTC_251 melphalan 456.522 µM 0.151985150325192 0.430257770546993 no 1423 0.439599323953337 2081 460612 A DNA alkylator.
SGTC_1563 conessine 56.1 µM 0.15155181131578 0.430412664187536 no 1424 0.439770221626803 2131 441082 An anti-amoebic, histamine inhibitor.
SGTC_3022 9087993 49.47 µM 0.151460103064665 0.430445445958449 no 1425 0.439806390424084 2130 17173644
SGTC_3118 9124250 49.47 µM 0.151326226765885 0.430493301860481 no 1426 0.43985919077047 2036 1504786
SGTC_623 k072-0108 16.9 µM 0.150008975439242 0.430964225574542 no 1427 0.440378767006874 2053 5382803
SGTC_385 1494-0393 12.4 µM 0.149520877632208 0.431138747862652 no 1428 0.440571318285457 2062 3090647
SGTC_2357 9067248 200 µM 0.147081124280219 0.432011297169124 no 1429 0.441533994239374 2049 9150235
SGTC_3201 9113999 49.47 µM 0.146737147103098 0.432134343373378 no 1430 0.441669748402303 2085 16649224
SGTC_2004 4023728 41.89 µM 0.146121537843456 0.432354573196901 no 1431 0.441912722080836 2168 360084 YDR527W RBA50
SGTC_2691 st077356 60.2 µM 0.145700731549834 0.432505125746821 no 1432 0.442078821919882 2097 2839272
SGTC_2203 7227154 166.4 µM 0.145650533090429 0.432523085985692 no 1433 0.442098636838288 2153 896304
SGTC_888 0916-0002 6.97 µM 0.145554701405268 0.432557373479958 no 1434 0.442136465035345 2126 2802138 YIL048W NEO1
SGTC_2623 humulene 100 µM 0.145211169412601 0.432680289517355 no 1435 0.442272073745506 2037 6187145 An anti-inflammatory.
SGTC_1068 loratadine 26.9 µM 0.144336385421517 0.432993317357386 no 1436 0.442617423850934 2021 3957 A H1 histamine antagonist.
SGTC_1499 4480-0877 67.3 µM 0.143428919870451 0.433318084218209 no 1437 0.442975722168783 2153 2861909
SGTC_1238 0333-0287 48.8 µM 0.143127550308448 0.433425949355248 no 1438 0.443094723470178 2069 7226
SGTC_790 1575-0012 79.1 µM 0.142950633417238 0.433489273139287 no 1439 0.443164584742784 2174 378741 YLR208W SEC13
SGTC_591 4299-0174 154 µM 0.142616743485514 0.433608786864357 no 1440 0.443296436635047 2081 5509088
SGTC_3288 9119690 36.221 µM 0.141472182402007 0.434018521052182 no 1441 0.443748467113562 2014 17595618 YKL019W RAM2
SGTC_285 1486-1325 46 µM 0.140349828107114 0.434420374428657 no 1442 0.444191798378391 2144 22310230
SGTC_2136 5328288 199.296 µM 0.139762160705414 0.434630812879442 no 1443 0.444423955584887 2047 262395
SGTC_2868 9035608 32.47 µM 0.139387218412243 0.43476508604982 no 1444 0.444572085996204 2157 6462614
SGTC_2446 5162541 200 µM 0.137428473752801 0.435466667589829 no 1445 0.445346062883076 2051 1549321
SGTC_870 0573-2213 57.6 µM 0.137361778449992 0.43549056004742 no 1446 0.445372420499565 2165 3916321
SGTC_2866 9034245 58.44 µM 0.136092113630282 0.435945440682171 no 1447 0.445874230967822 2188 6462273
SGTC_2523 spermine 47.74 µM 0.135787298046371 0.436054659075604 no 1448 0.445994716371225 2151 1103 A DNA binding polyamine.
SGTC_120 rhodamine 6G 52.259 µM 0.135748316847033 0.436068626770963 no 1449 0.446010124950955 2184 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase
SGTC_1825 st052143 62.6 µM 0.135279900346376 0.436236475425583 no 1450 0.446195288091971 2159 674173
SGTC_1133 3473-0247 50 µM 0.132183797208236 0.437346195876261 no 1451 0.447419458307461 1927 711311
SGTC_2425 5628681 7.85 µM 0.131601515020178 0.437554955660003 no 1452 0.447649743568537 2113 5714958
SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM 0.131438852467684 0.437613276539926 no 1453 0.447714077713179 2167 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_265 mycophenolic acid 32.932 µM 0.130960201860008 0.437784899340181 no 1454 0.44790339525305 2151 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1
SGTC_1998 st075797 76.8 µM 0.130798273538424 0.437842962279067 no 1455 0.447967444390169 2190 24208315
SGTC_1835 st008666 49.2 µM 0.130438586495976 0.437971940715907 no 1456 0.448109719873437 2032 690455
SGTC_103 0844-0104 51.839 µM 0.127394481871071 0.439063774015372 no 1457 0.449314091743026 2167 5375804
SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM 0.126541268707052 0.43936988075743 no 1458 0.44965174193742 2145 616764
SGTC_2101 5377231 179.231 µM 0.125310193344745 0.439811616732022 no 1459 0.450138991336202 2133 2844213
SGTC_1477 0139-0234 16 µM 0.124448892982268 0.440120714176863 no 1460 0.450479931600137 2184 620880
SGTC_738 1315-0003 72.4 µM 0.123247233452194 0.440552018278302 no 1461 0.450955661881715 2179 6251474
SGTC_2053 5265679 138 µM 0.121792831126297 0.441074132069297 no 1462 0.451531545807965 2133 764595
SGTC_1696 st025591 34.7925 µM 0.121131807832578 0.441311465780091 no 1463 0.451793317830162 2180 2787147
SGTC_911 3456-4043 236 µM 0.12024139985247 0.441631191037583 no 1464 0.452145961660506 2135 914281
SGTC_1755 st041960 45.185 µM 0.119270123935073 0.441979997501043 no 1465 0.452530676080465 2107 2257073
SGTC_1080 nisoldipine 24.4 µM 0.11790771927006 0.442469342626823 no 1466 0.453070388411786 2155 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class.
SGTC_3014 9081533 49.47 µM 0.116146747357819 0.44310197411257 no 1467 0.453768120227785 2210 21367265
SGTC_2227 7312221 64.1025 µM 0.116014162303344 0.443149611361174 no 1468 0.453820658846309 2184 887188 YOR168W | YOR169C GLN4 | YOR169C
SGTC_1946 st076057 65.1 µM 0.115054142284357 0.443494566962738 no 1469 0.45420110379909 2173 953009
SGTC_1168 k815-0004 80.5 µM 0.114771268338736 0.443596217764802 no 1470 0.454313211539311 2145 642433
SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM 0.114769580639676 0.4435968242509 no 1471 0.454313880413992 2133 5711223 A potent inhibitor of glutathione S-transferases.
SGTC_1264 0783-0040 158 µM 0.114668195520291 0.443633257923153 no 1472 0.454354061949866 2094 2855798
SGTC_3001 9076041 71.4286 µM 0.114457951452226 0.443708812574894 no 1473 0.454437388581103 2184 16004211
SGTC_3 0833-0587 95.581 µM 0.11409424515498 0.443839521224105 no 1474 0.454581542068161 2128 5382644
SGTC_2890 9046729 58.44 µM 0.112708331995779 0.44433764611451 no 1475 0.45513089768398 2076 903329
SGTC_505 gw-5074 63.9 µM 0.112337325926752 0.444471008064345 no 1476 0.455277973644074 2176 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases.
SGTC_1528 arabinosylhypoxanthine 74.6 µM 0.112057543988206 0.444571582720528 no 1477 0.4553888901634 2175 804 An inhibitor of viral and cellular DNA polymerases.
SGTC_6 0844-0013 19.835 µM 0.111546723832648 0.44475521907772 no 1478 0.455591408246065 2206 1584900
SGTC_1159 4092-0538 61.2 µM 0.110056734515158 0.445290927656118 no 1479 0.456182190252119 2216 717301
SGTC_593 1203-0218 61.7 µM 0.109312238499617 0.445558640161035 no 1480 0.456477419923635 2216 3666956
SGTC_1493 4348-0038 111 µM 0.109092579510288 0.445637631844257 no 1481 0.456564530227579 2207 800424
SGTC_1967 st070177 51.4 µM 0.108331536324234 0.445911327650815 no 1482 0.456866353722471 2177 5729214
SGTC_2565 isoliquiritigenin 100 µM 0.10761388651427 0.446169441407953 no 1483 0.457150990559762 1955 638278 Binds to benzodiazepine receptor 65X better than valium.
SGTC_3079 9117512 49.47 µM 0.106112034258754 0.446709679294898 no 1484 0.457746731548559 2233 7185044
SGTC_3070 9117005 49.47 µM 0.105178264609535 0.447045619619374 no 1485 0.458117178688242 2229 8779016
SGTC_1898 st060199 18.6 µM 0.104673453975745 0.447227250109462 no 1486 0.458317463440385 2196 688866
SGTC_1674 st016616 23.6 µM 0.102515679988177 0.448003739890058 no 1487 0.459173683794202 2210 625830
SGTC_1053 3366-3204 134 µM 0.101951451562754 0.448206814349962 no 1488 0.459397605123529 2119 3632071 YPR165W RHO1
SGTC_754 3474-0146 171 µM 0.101746721514009 0.448280503191932 no 1489 0.459478858073088 2035 24762078
SGTC_2536 dehydroabietamide 32.04 µM 0.101160937009844 0.448491355475287 no 1490 0.459711352672057 2209 3983547
SGTC_2918 7977171 22.06 µM 0.100913525463821 0.448580415276927 no 1491 0.459809553076267 2217 2236483
SGTC_1407 3909-7909 12.3 µM 0.100484067447105 0.448735011810681 no 1492 0.459980015574843 2172 4411780
SGTC_2212 7123476 200 µM 0.100253477317434 0.448818022986218 no 1493 0.46007154553238 2179 1085715
SGTC_740 k014-0057 261 µM 0.0997436385667113 0.44900157007465 no 1494 0.460273927350296 2210 4012779
SGTC_1838 st055369 84.5 µM 0.098699770839873 0.449377406985313 no 1495 0.460688325410717 2236 676036
SGTC_2291 7917025 104.35 µM 0.098151979564735 0.449574653405145 no 1496 0.460905806512319 2156 2964612
SGTC_610 4215-0184 155 µM 0.0962859139183019 0.450246671844873 no 1497 0.461646749084866 2176 5605015
SGTC_1609 st001574 46.4 µM 0.0935110258329143 0.451246243993388 no 1498 0.462748795364464 2229 3960012
SGTC_3142 9086498 49.47 µM 0.0921686769902899 0.451729897210761 no 1499 0.463282012113152 2254 25236367
SGTC_835 0312-0010 67.2 µM 0.089935942336693 0.452534518069947 no 1500 0.464169059508752 2223 1626196
SGTC_2386 9075165 157.42 µM 0.0898296801323379 0.452572817155662 no 1501 0.46421128109751 2151 16452277
SGTC_1991 st073000 8.92 µM 0.0892445964839062 0.452783701239825 no 1502 0.46444376194119 2215 4301969 YIL048W NEO1
SGTC_1398 3558-0053 112 µM 0.0887249578595444 0.452971007876382 no 1503 0.464650248625422 2177 4532369
SGTC_2516 gossypol 71.55 µM 0.0875640953509779 0.453389484973364 no 1504 0.465111570141606 2240 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_1458 k015-0034 6.33 µM 0.0875572801890436 0.453391941911296 no 1505 0.465114278595237 2069 3598957
SGTC_2144 5628481 200 µM 0.087498933374997 0.453412976627654 no 1506 0.465137466612279 2191 2818399
SGTC_412 gemfibrozil 100 µM 0.0852121607078039 0.454237487572671 no 1507 0.466046361449784 2254 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels.
SGTC_2584 androsterone 48.74 µM 0.0838932128645057 0.454713132822171 no 1508 0.466570667943886 2270 2754130 A steroid.
SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM 0.0813356762192182 0.455635628312009 no 1509 0.467587501223579 2230 23847180
SGTC_525 k781-2675 26.7 µM 0.0811966187359063 0.455685792814861 no 1510 0.467642794248519 2281 3651118 YDL195W SEC31
SGTC_2202 7226349 200 µM 0.0796595721692644 0.456240323896895 no 1511 0.468254006981201 2252 844334
SGTC_604 1000-0114 314 µM 0.0791448778355819 0.45642603289048 no 1512 0.468458694045413 2274 1572745
SGTC_1581 himbacine 57.9 µM 0.0774232685942403 0.457047282787411 no 1513 0.46914341533834 2126 5281825 An alkaloid muscarinic receptor antagonist.
SGTC_1331 1472-0049 76.2 µM 0.0725175419676464 0.458818105488766 no 1514 0.47109502287525 2272 24051409
SGTC_2451 5856223 45.7 µM 0.0721479042231056 0.458951567377002 no 1515 0.47124210173546 2232 2179896
SGTC_2427 5545055 42.75 µM 0.0715174424027763 0.459179213415405 no 1516 0.471492971536306 2223 5372858
SGTC_1955 wogonin 32.4 µM 0.0713078211904958 0.459254906040667 no 1517 0.471576385333857 2247 5281703 A flavanone.
SGTC_1226 3909-7979 35.4 µM 0.0707158452210903 0.459468672026936 no 1518 0.471811954873241 2276 6615510
SGTC_1324 1418-0026 34.4 µM 0.0701388970307701 0.459677022670747 no 1519 0.472041553783161 2189 1372513
SGTC_2962 9082311 13.18 µM 0.0677812691796378 0.460528536442768 no 1520 0.472979877247676 2222 16459453
SGTC_2585 alliin 100 µM 0.0673043634122893 0.460700804524559 no 1521 0.473169701633572 2242 87310 A garlic compound which reacts with lipids.
SGTC_1725 st036284 20.55 µM 0.0663539508711211 0.461044134866917 no 1522 0.473548015621004 2279 707914
SGTC_2116 5511452 16.8835 µM 0.0659331569797658 0.461196153210187 no 1523 0.473715521277223 2224 870744
SGTC_3261 9137475 49.47 µM 0.0658716165384254 0.461218386128359 no 1524 0.473740019104862 2290 17027690
SGTC_1118 chelidonine 707.474 nM 0.0649825732385749 0.461539587222434 no 1525 0.474093937732825 2296 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor.
SGTC_2624 nerol 100 µM 0.0645419137925288 0.461698801712277 no 1526 0.474269367141213 2277 637566 A natural product oil.
SGTC_3314 9135860 59.4275 µM 0.0631427664378691 0.462204367653192 no 1527 0.474826409765108 2282 25252478
SGTC_3223 9129970 49.47 µM 0.0628874237789749 0.462296639424677 no 1528 0.47492807469619 2285 17248386
SGTC_2019 4016004 108 µM 0.0628446573136768 0.462312093905413 no 1529 0.474945102366252 2231 45595336
SGTC_3205 9113483 49.47 µM 0.0614418936447967 0.462819040807896 no 1530 0.475503644530237 2271 17018033
SGTC_1633 st005664 67.9 µM 0.0612721301750589 0.46288039600028 no 1531 0.475571242992681 2282 2063822
SGTC_776 4476-4378 112 µM 0.0612329649180938 0.46289455106657 no 1532 0.475586838386167 2160 2892008
SGTC_2519 cryptotanshinone 88.04 µM 0.0597071835126422 0.463446033783048 no 1533 0.476194425164521 2301 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE)
SGTC_592 k241-0073 46.5 µM 0.0593885194453792 0.463561221522206 no 1534 0.476321328537793 2299 4230158
SGTC_2170 morpholine 200 µM 0.0579310086702256 0.464088107827877 no 1535 0.47690179162183 2258 121171 Reacts with secondary amines.
SGTC_1443 4112-3303 14 µM 0.0555221466601964 0.464959042736342 no 1536 0.477861243339086 2294 704433
SGTC_1775 st081588 35.1725 µM 0.0547874383447537 0.465224713442584 no 1537 0.478153904060157 2301 1426443 YGL099W LSG1
SGTC_2979 9012552 45.46 µM 0.0533810178599908 0.465733318571184 no 1538 0.47871416459984 2328 17100905
SGTC_2154 5570129 200 µM 0.052972555585295 0.465881041683702 no 1539 0.478876887236164 2310 673366
SGTC_323 4013-0906 34.3 µM 0.0510865636615343 0.466563183922354 no 1540 0.479628271328662 2319 2910086
SGTC_2782 7736369 71.43 µM 0.0509809508168927 0.466601385833064 no 1541 0.479670349926346 2256 2950836 YOL077C BRX1
SGTC_1635 st007035 42.4 µM 0.0505769625966528 0.466747517883029 no 1542 0.479831310254962 2315 3716403
SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM 0.050344685354147 0.46683154006074 no 1543 0.479923857566161 2332 16623 A steroid.
SGTC_1690 st023502 41.2 µM 0.0474816816027143 0.467867301184897 no 1544 0.481064664915301 2326 24207482
SGTC_1241 0364-0022 50.8 µM 0.0466197598401078 0.46817916524162 no 1545 0.481408141538515 2281 4563895
SGTC_2325 6158266 200 µM 0.0464927158168664 0.468225134485647 no 1546 0.481458769873048 2268 3623240
SGTC_231 b-estradiol 524 µM 0.0453820830106012 0.468627020641211 no 1547 0.481901380979418 2306 450 A steroid.
SGTC_1404 3909-7820 48.3 µM 0.0451519297979829 0.468710306355384 no 1548 0.481993104802813 2321 23741373
SGTC_1437 4092-1038 11.6 µM 0.0441218246386418 0.469083088003724 no 1549 0.482403648088557 2312 3977136
SGTC_1411 3909-8223 150 µM 0.0423769675056809 0.469714590757512 no 1550 0.483099094559888 2340 X1411
SGTC_248 streptozotocin 5.23457 mM 0.0413855066139649 0.470073456637384 no 1551 0.483494283472571 2331 5300 DNA alkylating agent.
SGTC_849 0386-0493 241 µM 0.0388570896590659 0.470988743373624 no 1552 0.484502164101491 2253 726119
SGTC_586 0957-0265 8.15 µM 0.0373219648368073 0.471544533525388 no 1553 0.48511414614221 2339 6752309 YPR165W | YPR107C RHO1 | YTH1
SGTC_2836 9010338 19.48 µM 0.0368409968690495 0.471718678870433 no 1554 0.485305892723645 2317 2994051
SGTC_2874 9043904 71.43 µM 0.0365492185983994 0.471824326438374 no 1555 0.485422217068363 2217 4463428
SGTC_665 3914-0008 307 µM 0.0354973841651342 0.472205192824705 no 1556 0.48584156609811 2333 1069549
SGTC_2484 5809818 12.04 µM 0.0345827908669654 0.472536385240586 no 1557 0.486206212095105 2318 2870548
SGTC_745 0469-0705 296 µM 0.0345378450407045 0.4725526615092 no 1558 0.486224132180315 2343 3486736
SGTC_2617 dihydrotanshinone i 20.83 µM 0.0330809944486265 0.473080256663999 no 1559 0.486804999343587 2336 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12
SGTC_1947 st076332 61.6 µM 0.0329068984037217 0.473143308331186 no 1560 0.48687441582297 2347 24208416
SGTC_2687 chenodiol 100 µM 0.0320454202049428 0.473455316311895 no 1561 0.487217914697429 2318 5702181 A cholesterol synthesis inhibitor.
SGTC_1442 4112-3290 3 µM 0.0307614754066775 0.473920362334984 no 1562 0.487729882020681 2354 704353
SGTC_2047 4141938 200 µM 0.0288154884074715 0.474625268221058 no 1563 0.488505874023332 2324 3807862
SGTC_1911 st060208 74.3 µM 0.0274602771292375 0.47511622113343 no 1564 0.489046311074467 2346 688783
SGTC_3173 9105693 49.47 µM 0.0273138012675921 0.475169287276313 no 1565 0.489104724578053 2337 17096658
SGTC_466 geldanamycin 89.2 µM 0.0268881597924256 0.475323493687818 no 1566 0.489274468610694 2367 5288382 HSP90 inhibitor.
SGTC_286 k060-0067 22.9 µM 0.0264917493774311 0.475467113251121 no 1567 0.489432557167081 2350 5985051
SGTC_2843 9000894 45.46 µM 0.0261315606407933 0.475597612458452 no 1568 0.489576201950796 2356 2242070
SGTC_474 dl-dihydrosphingosine 5 µM 0.0258218788243947 0.47570981470539 no 1569 0.489699705443846 2347 3058739 A sphingolipid protein kinase C inhibitor.
SGTC_2088 5278280 127.392 µM 0.0249124453115631 0.476039326855959 no 1570 0.490062400196307 2345 791502
SGTC_984 1492-0255 2.91 µM 0.0217825702985387 0.477173488352803 no 1571 0.491310698887996 2335 1585198
SGTC_2298 7976326 193.81 µM 0.0203161515140923 0.477704933403472 no 1572 0.491895585700602 2353 2235818
SGTC_1547 harmine 94.2 µM 0.0198605258367515 0.477870064890995 no 1573 0.492077317373937 2378 5280953 A monoamine oxidase inhibitor YHR072W ERG7
SGTC_2904 7225135 42.03 µM 0.0196108967079363 0.477960539081306 no 1574 0.492176885594868 2362 4446116
SGTC_3038 9091290 49.47 µM 0.0189378854579379 0.478204467174274 no 1575 0.492445328364448 2371 25236843
SGTC_2779 methotrexate 400 µM 0.0187656742736843 0.478266885196481 no 1576 0.492514018479959 2368 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2
SGTC_2045 5106652 78.05 µM 0.0185151821199 0.478357677142971 no 1577 0.49261393303081 2363 673349
SGTC_600 1495-0418 41.6 µM 0.0179254703232668 0.478571425117823 no 1578 0.49284915494857 2364 5377768
SGTC_63 0099-0242 26.702 µM 0.0163720363441882 0.479134514872303 no 1579 0.493468794261959 2383 3898502 YLR359W ADE13
SGTC_1777 st045864 34.765 µM 0.0161263831476735 0.479223563244559 no 1580 0.493566782770977 2380 4691462
SGTC_699 0375-0592 111 µM 0.0159023300328299 0.479304782571734 no 1581 0.493656155570366 2377 762578
SGTC_276 colchicine 750 µM 0.0149212789699505 0.47966042397621 no 1582 0.494047491824308 2312 2833 A microtubule depolymerizer.
SGTC_952 1185-0122 232 µM 0.014672381705989 0.479750654457845 no 1583 0.494146776596516 2373 678600
SGTC_2593 nobiletin 86.24 µM 0.013585593340596 0.480144650144391 no 1584 0.494580299130147 2367 72344 An anti-infammatory.
SGTC_3295 9122362 53.5725 µM 0.0135046719327586 0.4801739875344 no 1585 0.494612579139762 2346 4730473
SGTC_1459 k035-0031 35.7 µM 0.0132014992708112 0.480283901239887 no 1586 0.494733516750046 2385 3877128 YMR208W ERG12
SGTC_1931 st074438 57.1 µM 0.0122070840373889 0.480644431899183 no 1587 0.495130199001235 2382 2787313
SGTC_2258 7960471 200 µM 0.0109391187952898 0.481104162530594 no 1588 0.495636010038047 2360 2974708
SGTC_1136 pergolide 1.05886 µM 0.00965687838012166 0.481569094517527 no 1589 0.496147522794888 2378 47811 A dopamine receptor agonist.
SGTC_3320 9137005 35.139 µM 0.00875618074294749 0.481895696616327 no 1590 0.496506833924107 2376 4908713
SGTC_77 0828-0286 12.516 µM 0.00872795042747539 0.481905933412584 no 1591 0.496518095760194 2386 745345
SGTC_866 0495-0101 262 µM 0.00861081970601432 0.481948407147166 no 1592 0.496564822401313 2378 635694
SGTC_1530 rhein 70.4 µM 0.00828806983629227 0.482065443191472 no 1593 0.496693576373625 2393 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death.
SGTC_674 0498-0004 451 µM 0.00821078790554649 0.482093467511437 no 1594 0.496724406354247 2387 4231473
SGTC_2414 st077232 92.9 µM 0.00760484575246927 0.482313200025384 no 1595 0.496966134736702 2381 729801
SGTC_515 4092-1064 102 µM 0.00689864046442339 0.482569297687336 no 1596 0.497247862471077 2393 717353
SGTC_107 0358-0022 2.6945 µM 0.00600758561881909 0.482892439279094 no 1597 0.497603334509906 2372 521106 YGL093W | YPR107C SPC105 | YTH1
SGTC_407 eburnamonine 100 µM 0.00563378423430261 0.483028001941115 no 1598 0.497752457159608 2391 3195
SGTC_819 1013-0258 27.7 µM 0.00450655240198742 0.483436815207142 no 1599 0.498202151793426 2394 5753198
SGTC_278 4092-0821 23.9 µM 0.00423408868711967 0.483535632275669 no 1600 0.498310848050787 2382 877900
SGTC_1370 2001-0092 44.6 µM 0.00229594401950803 0.484238586901485 no 1601 0.499084051661899 2382 790957
SGTC_1177 0983-0204 23.6 µM 0.00210610017157361 0.484307444911671 no 1602 0.499159788215947 2404 766818
SGTC_2390 9097792 176.6 µM 0.000195733370642918 0.485000377223222 no 1603 0.499921913683264 2404 4497149
SGTC_1312 1218-2183 165 µM 0 0.485071376641647 no 1604 0.5 2405 6744073
SGTC_1203 3992-3522 103 µM -0.00093526241340069 0.485410635902337 no 1605 0.499626884334419 2408 5322312
SGTC_507 nimesulide 162 µM -0.00120075891694079 0.485506944655933 no 1606 0.499520966614577 2408 4495 A COX2 inhibitor.
SGTC_925 2064-1272 59.6 µM -0.00156114756153307 0.485637676848409 no 1607 0.499377192484741 2409 6815817
SGTC_38 0929-0051 58.268 µM -0.00188652161327395 0.485755708705971 no 1608 0.499247387211994 2412 1379719
SGTC_1482 3346-2049 8.48 µM -0.00281537456651733 0.48609266385514 no 1609 0.49887682953402 2414 3826804
SGTC_1381 2324-0066 62.1 µM -0.00298963650381953 0.486155881064176 no 1610 0.498807309372292 2415 10885928
SGTC_2393 9031399 185.94 µM -0.00333819863688119 0.486282330403645 no 1611 0.498668253896771 2409 1526623 YDL150W RPC53
SGTC_904 1141-0088 396 µM -0.00335057030943369 0.486286818552341 no 1612 0.498663318341113 2415 1378119
SGTC_1857 st056007 79.3 µM -0.003953606069518 0.486505587685258 no 1613 0.498422743487835 2418 619834
SGTC_2829 7992743 58.44 µM -0.00423352840632695 0.486607139211074 no 1614 0.498311071568481 2411 16462845
SGTC_3011 9081274 71.4286 µM -0.0050739834203774 0.486912048577592 no 1615 0.497975782169244 2416 6625322
SGTC_1632 st005650 90 µM -0.00586474080625127 0.487198935089583 no 1616 0.497660320341084 2426 2759605
SGTC_1405 3909-7894 12 µM -0.00667694790923667 0.487493610446784 no 1617 0.497336302966976 2424 7104060
SGTC_1512 0259-0544 12.2 µM -0.00686063854347253 0.487560255858627 no 1618 0.497263022685313 2424 18476
SGTC_3335 9143315 29.6265 µM -0.00710289743103818 0.487648151144746 no 1619 0.497166377728009 2424 4899691
SGTC_2016 5121758 140 µM -0.0077227626693028 0.487873050599643 no 1620 0.496919094074491 2422 2795203
SGTC_2743 auranofin 4.32 µM -0.00774968184973361 0.487882817502369 no 1621 0.496908355196624 2419 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold.
SGTC_1376 2910-0861 41.3 µM -0.00896086810101076 0.488322271383646 no 1622 0.496425178686802 2418 1112859
SGTC_642 0335-0876 158 µM -0.00927266853523878 0.488435404038666 no 1623 0.496300793480319 2425 6812350
SGTC_2255 7941087 197.44 µM -0.00973372634773707 0.488602694457822 no 1624 0.496116866332321 2422 935561
SGTC_1412 3909-8563 178 µM -0.00988368364058397 0.488657105461396 no 1625 0.496057044905806 2424 23767530
SGTC_1827 berberine 7.24 µM -0.0109793260301996 0.489054658336677 no 1626 0.495619970635296 2429 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_907 3448-6986 75.5 µM -0.013449948499588 0.489951160825712 no 1627 0.494634408648356 2434 590582
SGTC_195 4234-0266 16.654 µM -0.0134950095602154 0.489967512393887 no 1628 0.49461643351746 2433 2303354
SGTC_2600 tangeritin 87.95 µM -0.013668146104345 0.4900303396115 no 1629 0.494547368399954 2432 68077 A bioactive flavone.
SGTC_2834 9001755 58.44 µM -0.0137187253070606 0.490048693672377 no 1630 0.494527192109203 2484 2989575
SGTC_3016 9080866 49.47 µM -0.014448498358077 0.49031351430879 no 1631 0.494236083662353 2423 17066299
SGTC_2167 5876490 200 µM -0.0145464033893679 0.490349042493338 no 1632 0.494197029310283 2461 686534
SGTC_991 3996-0057 64.7 µM -0.0146837765740506 0.490398893174408 no 1633 0.494142231191538 2446 715343
SGTC_2440 5628896 157.78 µM -0.0154667125357778 0.490683011804503 no 1634 0.49382992043189 2439 5522048
SGTC_2683 piperine 63.03 µM -0.0155224634947781 0.490703243380731 no 1635 0.493807681686899 2436 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_499 genistein 192 µM -0.017441695168328 0.49139973140493 no 1636 0.493042123136389 2432 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger.
SGTC_3215 9129942 49.47 µM -0.0187186406303799 0.491863148806508 no 1637 0.492532778893612 2442 17682944
SGTC_1654 st012436 41.8 µM -0.0192611306748219 0.492060027706346 no 1638 0.492316395699953 2445 4323132
SGTC_806 3966-4455 5.86 µM -0.0193048398560309 0.492075890599358 no 1639 0.492298961501139 2450 714982
SGTC_1180 1193-0155 285 µM -0.0196312993382638 0.492194369347868 no 1640 0.492168747689645 2468 2921347
SGTC_2897 9048598 12.99 µM -0.0202848350885792 0.492431552747587 no 1641 0.491908076572738 2455 6467404
SGTC_2793 7325131 81.82 µM -0.0208799989022498 0.492647553937305 no 1642 0.491670690855083 2459 4176441
SGTC_2276 7947513 42.08 µM -0.0217415196568004 0.492960227131936 no 1643 0.491327071847156 2491 2105100
SGTC_214 4373-3496 70 µM -0.0227717703422376 0.493334143430194 no 1644 0.490916163093615 2462 3779166
SGTC_709 3807-1509 243 µM -0.0236132944158863 0.493639568181304 no 1645 0.490580533849105 2437 1886677 YPL242C IQG1
SGTC_55 0767-0285 6.563 µM -0.0254042061388729 0.494289578133889 no 1646 0.489866278089142 2449 3116166
SGTC_3195 9113082 49.47 µM -0.0255312481818629 0.49433568853624 no 1647 0.48981561208062 2441 17018038
SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM -0.0263847459091103 0.494645470779098 no 1648 0.489475230458208 2452 16725076
SGTC_480 am 92016 50 µM -0.0265973344792375 0.494722631616065 no 1649 0.489390449643171 2486 2129 K+ channel blocker.
SGTC_155 k072-0202 43.6 µM -0.0268552409737835 0.494816241245491 no 1650 0.489287596578639 2440 5857737
SGTC_1318 1280-3875 124 µM -0.0271311178686848 0.494916373719471 no 1651 0.489177577710347 2475 373245
SGTC_1440 4100-1550 40 µM -0.0279193438945086 0.495202470541802 no 1652 0.488863240129925 2454 742806
SGTC_1779 st039427 55 µM -0.0282410415396586 0.495319235576808 no 1653 0.48873495192574 2449 1124498
SGTC_2605 digitonin 300 nM -0.0284990610095206 0.495412887943458 no 1654 0.488632058466069 2459 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_2142 5622915 118.518 µM -0.0292461106220296 0.495684043168097 no 1655 0.488334152993792 2481 5322196
SGTC_1314 1222-0010 41.1 µM -0.0302351345080349 0.496043030396629 no 1656 0.487939764023415 2480 3526027
SGTC_3185 9108267 49.47 µM -0.0310226091061809 0.496328863335236 no 1657 0.487625754444687 2478 4910486
SGTC_688 0527-0193 473 µM -0.0319061113473043 0.496649554064147 no 1658 0.487273462486064 2485 4007154
SGTC_3228 9131799 49.47 µM -0.0323057034724223 0.496794597419004 no 1659 0.487114130433551 2487 17015818
SGTC_797 k781-0471 270 µM -0.0329370216064795 0.497023753191693 no 1660 0.486862404914578 2531 23738129
SGTC_1057 3448-5381 134 µM -0.0332141710012026 0.497124353156938 no 1661 0.486751898766514 2496 5497911
SGTC_879 0831-1030 162 µM -0.0336845318012976 0.497295085606993 no 1662 0.486564356903854 2469 1549252
SGTC_2385 9074692 200 µM -0.0341577796123467 0.497466866489661 no 1663 0.48637566693348 2470 17046906
SGTC_305 1682-2595 20.8 µM -0.0353825307520583 0.4979114323637 no 1664 0.485887357214972 2513 226033
SGTC_1723 st034307 2.5525 µM -0.0359337209769745 0.498111506838494 no 1665 0.4856676038853 2494 867466
SGTC_2067 5224629 34.075 µM -0.0359658787116371 0.498123179669277 no 1666 0.485654783092699 2515 2835000
SGTC_1877 wortmannin 25 µM -0.0361096211140181 0.49817535627264 no 1667 0.485597475396347 2468 312145 A covalent inhibitor of PI 3-kinase.
SGTC_2942 9052777 62.25 µM -0.0364654421265468 0.49830451475725 no 1668 0.48545561678034 2482 6469503
SGTC_1010 4112-3296 15.2 µM -0.0371560511772395 0.498555197520393 no 1669 0.485180290237474 2475 704384
SGTC_22 0964-0034 14.468 µM -0.0375911666434332 0.498713139490426 no 1670 0.485006825471468 2485 138402
SGTC_2173 5763948 167 µM -0.0376658709472183 0.498740256324814 no 1671 0.484977043857606 2483 2867177
SGTC_1005 4092-0690 4.4 µM -0.0378620903664589 0.498811481826859 no 1672 0.484898819433691 2493 1529343
SGTC_966 1300-0360 30.2 µM -0.0382884602338714 0.498966249550696 no 1673 0.484728845720149 2498 70588
SGTC_1545 lovastatin 49.4 µM -0.0384031833165063 0.499007892836178 no 1674 0.484683111468205 2495 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12
SGTC_2434 5670830 169.91 µM -0.0384991221361916 0.49904271763795 no 1675 0.484644865700183 2527 1549830
SGTC_3286 9117135 37.221 µM -0.0402772061513924 0.499688144831135 no 1676 0.483936062943059 2499 3438150
SGTC_2783 7738165 71.43 µM -0.0405214993443832 0.499776820984458 no 1677 0.483838683559057 2495 17201110
SGTC_935 2996-0153 430 µM -0.0410493856791146 0.499968438838266 no 1678 0.483628262468855 2476 23738523
SGTC_1041 0206-0046 107 µM -0.0412232808007317 0.499968438838266 no 1679 0.483558947025116 2574 50494
SGTC_2885 9057732 51.95 µM -0.0416824372291138 0.49980176930238 no 1680 0.483375927426596 2526 6471414
SGTC_1515 3460-0031 42.1 µM -0.0419134957966846 0.49971789719112 no 1681 0.4832838288814 2493 2876596
SGTC_2655 perillic acid 100 µM -0.0419446021829032 0.499706605863072 no 1682 0.483271430132319 2482 5702197 An apoptosis inducer.
SGTC_1334 1486-0610 236 µM -0.042269695889513 0.499588599895703 no 1683 0.483141851431458 2591 3742339
SGTC_230 MPP+ 141.667 µM -0.0424794825695303 0.499512449316312 no 1684 0.483058233760985 2503 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death.
SGTC_2187 6125751 200 µM -0.0430894704883805 0.499291029585735 no 1685 0.482815106418941 2508 874498
SGTC_3303 9125618 40.5795 µM -0.0431053421005585 0.499285268346232 no 1686 0.482808780439409 2523 22695467
SGTC_3027 9089541 49.47 µM -0.0433399185124442 0.499200119428192 no 1687 0.48271528536529 2530 9943819
SGTC_2709 st078560 56 µM -0.0447891174093621 0.498674075514566 no 1688 0.482137699719128 2499 17250903
SGTC_694 1315-0438 43.2 µM -0.0452015622415064 0.498524362772466 no 1689 0.481973324518088 2519 6793154
SGTC_1524 corynanthine 62.1 µM -0.0461693349711857 0.498173073227878 no 1690 0.481587641774362 2654 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist.
SGTC_2430 5571206 200 µM -0.046744764688304 0.497964200003767 no 1691 0.481358326128638 2493 1731771
SGTC_1018 4259-0013 28.1 µM -0.0470120757325168 0.497867169887411 no 1692 0.48125180156419 2606 6801262
SGTC_2612 dictamnine 15.46 µM -0.0473840977438101 0.497732131386908 no 1693 0.481103551472848 2537 68085 A quinoline derivative and established mutagen. YOR116C RPO31
SGTC_526 4469-0568 170 µM -0.0481391828063621 0.497458047466589 no 1694 0.480802659512533 2490 2901964
SGTC_2583 asiatic acid 100 µM -0.0483286104246348 0.497389288424086 no 1695 0.480727176683463 2546 5320556 A kinase inhibitor; arrests cells at G2/M.
SGTC_2786 7743617 45.45 µM -0.0485856269968468 0.497295995851381 no 1696 0.48062476221625 2509 583674
SGTC_2231 micatex 6.853 µM -0.0493104957400377 0.497032881841618 no 1697 0.480335927651704 2519 20737 An antifungal of unknown mechanism.
SGTC_2482 5981709 142.65 µM -0.0507990512573659 0.496492567764139 no 1698 0.479742823444865 2553 877755
SGTC_2128 5255449 168.493 µM -0.0512513492048314 0.496328394432307 no 1699 0.479562617414178 2502 736008
SGTC_322 k048-0136 19.3 µM -0.0513805826563177 0.496281485894864 no 1700 0.479511128564548 2566 6823282
SGTC_2767 sibutramine 71.45 µM -0.0514054404843187 0.496272463125738 no 1701 0.4795012248137 2524 64765 A serotonin-norepinephrine reuptake inhibitor.
SGTC_2193 5925765 200 µM -0.0517627747842207 0.496142759935486 no 1702 0.47935885859262 2532 877370
SGTC_2205 7238770 200 µM -0.0526847954443288 0.495808091989491 no 1703 0.478991526838893 2540 279867
SGTC_427 1354-0053 47.3 µM -0.053213336357841 0.495616247601495 no 1704 0.478780964897105 2730 6813657
SGTC_765 1319-0117 244 µM -0.0542543324877194 0.49523840045442 no 1705 0.478366266662499 2509 3487746 YGL099W LSG1
SGTC_1915 st067105 30.6 µM -0.0544493418207911 0.495167618984506 no 1706 0.478288584021376 2485 69751 YOR207C | YOR116C RET1 | RPO31
SGTC_3093 9117344 49.47 µM -0.0545711792423274 0.495123396399768 no 1707 0.478240050082319 2634 24824913
SGTC_1866 st057638 64 µM -0.054651685010256 0.495094175745743 no 1708 0.478207980785231 2528 688802
SGTC_2307 7538926 6.34 µM -0.0556099753103741 0.494746353424727 no 1709 0.477826258827685 2543 96582
SGTC_1343 1487-0095 224 µM -0.0559946441942372 0.494606734603909 no 1710 0.477673036891432 2499 4560101 YGL055W OLE1
SGTC_2421 5690543 90.72 µM -0.0567887154402368 0.494318521846099 no 1711 0.477356751603082 2554 3397993
SGTC_1185 1319-0113 81.3 µM -0.0569222227937323 0.494270064866033 no 1712 0.477303575890986 2562 4672763
SGTC_1837 st055472 66.5 µM -0.0571438431793858 0.494189627127126 no 1713 0.477215305826906 2627 676091
SGTC_1735 st034310 56.75 µM -0.0573657069858323 0.494109101274598 no 1714 0.4771269399295 2719 871153
SGTC_2515 chrysin 20.77 µM -0.0573989588791643 0.494097032462968 no 1715 0.47711369616539 2559 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor.
SGTC_109 0132-0036 33.701 µM -0.0576710311262936 0.493998283742547 no 1716 0.477005334544946 2497 67274 A color developer.
SGTC_467 ro 31-8220 72.8 µM -0.0580340541560064 0.493866524976506 no 1717 0.476860751466748 2518 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7
SGTC_883 0850-0245 24.6 µM -0.0582572361243768 0.493785521684411 no 1718 0.476771865129223 2675 6823229 YPR165W RHO1
SGTC_519 k048-0011 62.8 µM -0.0596925236421692 0.493264594227181 no 1719 0.476200263193823 2616 6836379
SGTC_3113 9123498 49.47 µM -0.0599613901697464 0.493167012272449 no 1720 0.476093192756795 2495 8897275
SGTC_2958 9077254 16.72 µM -0.0603854905971755 0.493013090826757 no 1721 0.475924307197401 2602 16457351
SGTC_1659 st012954 42.1 µM -0.0630176496172283 0.492057808888641 no 1722 0.474876224946052 2596 24207262
SGTC_1070 indatraline 8.81 µM -0.065403685298432 0.49119189100115 no 1723 0.473926294960368 2543 10314472 A monamine transport inhibitor. YGL099W LSG1
SGTC_2909 7941780 10.49 µM -0.065490121679463 0.491160523067788 no 1724 0.473891885605136 2519 1243215
SGTC_2745 rifampicin 24.3 µM -0.0658536489965188 0.491028598887268 no 1725 0.47374717158684 2561 25141428 Inhibits bacterial DNA-dependent RNA polymerase.
SGTC_2641 levomentholum 100 µM -0.066131989405502 0.49092758972574 no 1726 0.473636371362965 2526 16666
SGTC_327 1273-0057 3.96 µM -0.0665921468535357 0.49076060081404 no 1727 0.473453198886151 2528 3108138
SGTC_2204 7233102 200 µM -0.0671187587888668 0.490569497879199 no 1728 0.473243580107507 2512 2172480
SGTC_2190 6049624 200 µM -0.0675359521789714 0.49041810352647 no 1729 0.473077520824241 2516 2265554
SGTC_1939 st074455 53.6 µM -0.0683904498663616 0.490108021153048 no 1730 0.472737411967134 2533 1644229
SGTC_2591 skatole 100 µM -0.0690940361053295 0.489852706403484 no 1731 0.472457384091817 2588 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite.
SGTC_2809 7964133 12.99 µM -0.0697598714459175 0.489611094386509 no 1732 0.472192393638246 2560 1253665
SGTC_2795 7780010 54.55 µM -0.0698209772847429 0.489588921068574 no 1733 0.472168075231609 2609 953673
SGTC_2981 9013952 38.96 µM -0.0709816302552992 0.489167764110213 no 1734 0.471706187770592 2592 2996344
SGTC_549 1661-1316 519 µM -0.071404448895081 0.489014342233093 no 1735 0.471537934471856 2544 2857282
SGTC_1122 capsaicin 818.572 nM -0.072123492019279 0.488753437551851 no 1736 0.471251815489771 2651 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_2124 5246320 200 µM -0.0728223110042624 0.48849987580677 no 1737 0.470973758238671 2615 579342
SGTC_1895 st058434 18.3 µM -0.0728443489350972 0.488491879567597 no 1738 0.470964989664461 2531 5393175
SGTC_2237 6667747 47.222 µM -0.0734803501406251 0.488261115001513 no 1739 0.470711940057574 2603 729940 YDL015C TSC13
SGTC_675 1309-0189 238 µM -0.0749774108737558 0.487717942105051 no 1740 0.470116342402294 2568 4246530
SGTC_3353 9151644 39.2805 µM -0.0756457472948386 0.487475459418873 no 1741 0.469850469814053 2606 4909158
SGTC_398 bronopol 33.3 µM -0.0756489888886284 0.487474283330226 no 1742 0.469849180300155 2551 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them.
SGTC_148 3253-0744 288.01 µM -0.0756788362854529 0.487463454346018 no 1743 0.469837306947929 2527 6893655
SGTC_1754 st042065 16.137 µM -0.0769073105779191 0.487017757635141 no 1744 0.469348640887324 2590 1126236 YIL048W NEO1
SGTC_3034 9090421 49.47 µM -0.0769383887046826 0.487006482540893 no 1745 0.469336279135731 2525 17173761
SGTC_3128 9127691 49.47 µM -0.0773530180916692 0.48685605666544 no 1746 0.469171357437066 2677 41316314
SGTC_2925 9010536 32.5 µM -0.077668976227492 0.486741429577754 no 1747 0.46904568645873 2590 2994177
SGTC_2021 4019055 173 µM -0.0792007645163651 0.486185724723229 no 1748 0.468436468254176 2632 44827708 YER133W GLC7
SGTC_833 3852-0053 558 µM -0.0804506512220984 0.485732308446166 no 1749 0.467939421785 2639 3123681
SGTC_357 1325-0123 420 µM -0.0804746625494902 0.48572359813405 no 1750 0.467929873609961 2542 1098503
SGTC_3300 9124615 50.48 µM -0.082947454406494 0.484826609197938 no 1751 0.466946660430359 2681 24824903
SGTC_70 0141-0289 43.283 µM -0.0830401093727967 0.484793000684032 no 1752 0.466909823531225 2667 352408
SGTC_2540 epiandrosterone 100 µM -0.0832891479215975 0.484702668064039 no 1753 0.466810814508419 2563 441302 A steroid.
SGTC_2640 pentamidine 10.38 µM -0.0839745068871339 0.484454074991116 no 1754 0.466538350358814 2595 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_1392 3455-1037 33.9 µM -0.0853767795893429 0.483945462247656 no 1755 0.465980926475816 2669 981132
SGTC_890 0929-0006 47.2 µM -0.0859685531142979 0.483730830220791 no 1756 0.465745707815273 2558 1378169
SGTC_1297 1068-0111 14.1 µM -0.0860982303347007 0.483683797847567 no 1757 0.465694165195348 2545 767057
SGTC_3312 9133330 71.43 µM -0.0862591107025982 0.483625448782433 no 1758 0.465630221104802 2705 17617324
SGTC_2341 7987486 176.74 µM -0.0863260572063522 0.483601168322686 no 1759 0.46560361256763 2579 1258686
SGTC_2597 laccaic acid a 100 µM -0.0871100638307331 0.483316825816303 no 1760 0.465292013008185 2632 5491415 A textile dye.
SGTC_1111 tnp00062 510.699 nM -0.0872134830725155 0.483279318490046 no 1761 0.465250911126051 2675 676306
SGTC_1480 1070-0044 41.2 µM -0.0873839196646068 0.483217506129517 no 1762 0.465183175365071 2659 3124987
SGTC_1492 4158-0558 28.5 µM -0.0874747077615777 0.483184580110138 no 1763 0.465147094318188 2665 3967268
SGTC_376 3970-0862 59.1 µM -0.0879464983145539 0.483013478200096 no 1764 0.464959599721739 2628 3135186
SGTC_1016 4226-1401 38 µM -0.0896725930239296 0.482387510999229 no 1765 0.464273697887818 2555 2901613
SGTC_1800 st050079 29.0735 µM -0.0909957309442945 0.481907705147734 no 1766 0.463747991598785 2598 3645560
SGTC_2029 5175081 200 µM -0.0911400452815372 0.481855374410469 no 1767 0.463690656750931 2556 1380876
SGTC_1505 k297-0037 20.6 µM -0.0916437544620677 0.481672723685133 no 1768 0.463490543333013 2590 4089396
SGTC_2950 9072895 21.46 µM -0.0923688717654776 0.481409794600312 no 1769 0.463202485201927 2633 17332245
SGTC_500 h-89 112 µM -0.092710580038711 0.481285893245979 no 1770 0.463066745780033 2711 449241 Protein kinase A inhibitor; also known to inhibit several other kinases.
SGTC_2260 7964312 200 µM -0.0929084199542907 0.481214158514012 no 1771 0.462988158263818 2770 231951
SGTC_2364 9055074 200 µM -0.0929332344177056 0.481205161086004 no 1772 0.462978301370772 2622 6470630
SGTC_1732 st034308 51.822 µM -0.0940846789714363 0.480787671651192 no 1773 0.462520945400393 2539 830119
SGTC_131 0141-0277 33.849 µM -0.0940993563081703 0.480782350094452 no 1774 0.462515115852796 2671 1547771
SGTC_2052 5265182 7.135 µM -0.0970355943958579 0.479717829436153 no 1775 0.461349063787696 2654 1239884
SGTC_411 enrofloxacin 100 µM -0.0973824221388457 0.479592097914194 no 1776 0.461211351738523 2673 71188 A bacterial gyrase inhibitor.
SGTC_3126 9127922 49.47 µM -0.09853042533425 0.479175939909047 no 1777 0.460755556786275 2804 45595682
SGTC_1856 st057054 55.7 µM -0.0996579457430855 0.478767229129754 no 1778 0.460307944351202 2753 1266018
SGTC_2766 oltipraz 83.91 µM -0.100003860397266 0.478641844238263 no 1779 0.460170630328738 2641 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40
SGTC_963 1269-2853 151 µM -0.100701059839218 0.478389134360561 no 1780 0.459893885011235 2619 3668223
SGTC_1056 3448-1962 115 µM -0.100746815517077 0.478372549865484 no 1781 0.459875723497937 2673 715507
SGTC_2854 9024559 71.43 µM -0.101239133115842 0.478194107964948 no 1782 0.459680316275636 2653 3163529
SGTC_2686 alizarin 95.37 µM -0.10208795752517 0.477886459452242 no 1783 0.459343429787485 2641 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1
SGTC_3338 9144300 39.5675 µM -0.102606733047816 0.47769844056496 no 1784 0.459137549424726 2641 4901274
SGTC_307 1501-1223 22.3 µM -0.102937187633706 0.477578677084203 no 1785 0.459006411495532 2634 2830329
SGTC_2846 9008642 19.48 µM -0.103069510252982 0.477530721235711 no 1786 0.458953901704544 2713 2992898
SGTC_491 tetrandrine 80.3 µM -0.103340881787716 0.47743237283927 no 1787 0.458846215157353 2673 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_300 r073-0011 5.04 µM -0.103638878330217 0.477324376794656 no 1788 0.458727966665951 2596 2735780
SGTC_2423 st077119 87.2 µM -0.106259880329019 0.476374579842039 no 1789 0.4576880810894 2541 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae).
SGTC_3282 9108498 15.4605 µM -0.106325237296568 0.476350897520478 no 1790 0.457662154307985 2686 16459645
SGTC_2132 5317594 122.667 µM -0.106435254525105 0.476311032588728 no 1791 0.457618511431859 2610 794577
SGTC_1601 4'-hydroxyflavanone 55.5 µM -0.108481908698292 0.475569467591067 no 1792 0.45680671529225 2768 165506
SGTC_1681 tripelennamine 100 µM -0.109988805688745 0.475023526963024 no 1793 0.456209126407444 2585 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist.
SGTC_340 k038-0059 454 µM -0.111734630058962 0.474391082939543 no 1794 0.455516910215687 2588 23733424
SGTC_1647 st011722 22.4 µM -0.111797118873728 0.474368446867868 no 1795 0.455492136004559 2707 2854783
SGTC_2666 tannic acid 100 µM -0.112041086863134 0.474280072214402 no 1796 0.455395414520768 2631 16134267 A thiamine antagonist.
SGTC_1919 st067113 52.3 µM -0.112425110896789 0.474140966403711 no 1797 0.455243172961553 2723 1268243
SGTC_2322 7413319 38.22 µM -0.113928628309874 0.473596374711312 no 1798 0.454647185603234 2710 1840400
SGTC_1559 coumarin 343 70.1 µM -0.115027456756296 0.473198397273157 no 1799 0.454211679570536 2716 108770 A hepatotoxic, DNA x-linker.
SGTC_3204 9114183 49.47 µM -0.11560392417234 0.472989621009512 no 1800 0.453983226361089 2594 17027248
SGTC_3073 9114972 49.47 µM -0.116476887487982 0.472673478482315 no 1801 0.45363730125975 2655 41905075
SGTC_2032 5185112 25.99 µM -0.118009638904227 0.472118436320043 no 1802 0.453030010255862 2691 5718189
SGTC_430 0958-0115 16.4 µM -0.118967590541493 0.471771568910415 no 1803 0.452650516194981 2647 6833180
SGTC_2977 9011197 71.43 µM -0.120706629508673 0.471141930282008 no 1804 0.451961703903288 2844 2704722
SGTC_3141 9094609 49.47 µM -0.120855291027411 0.471088109030425 no 1805 0.451902827553339 2617 25236309 YDL196W YDL196W
SGTC_2445 5742597 35.57 µM -0.121094278664184 0.471001587318334 no 1806 0.451808180396666 2631 1774255
SGTC_3213 9129884 49.47 µM -0.121211593949324 0.470959115666574 no 1807 0.451761720592858 2708 17190742
SGTC_1929 genistein trimethyl ether 50.5 µM -0.122629626931211 0.470445771464106 no 1808 0.451200196302564 2630 136420
SGTC_537 1334-0398 209 µM -0.12375131743722 0.470039741382196 no 1809 0.450756089235396 2613 5846986
SGTC_3265 9137266 49.47 µM -0.126708951107823 0.468969286137596 no 1810 0.449585380493431 2598 17224265
SGTC_2334 9017922 200 µM -0.126847598121513 0.468919111118965 no 1811 0.449530511065018 2767 3163164
SGTC_1229 0139-0193 12.2 µM -0.126959621499614 0.468878571298094 no 1812 0.449486178620728 2692 3090752
SGTC_2592 piperlongumine 83.33 µM -0.128207981724153 0.468426827705124 no 1813 0.448992191849252 2723 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_1213 1315-0166 115 µM -0.130163841838353 0.467719143378044 no 1814 0.448218400593393 2768 768401
SGTC_1254 0550-0035 264 µM -0.131966260895157 0.467067068540473 no 1815 0.447505489105725 2754 15121435
SGTC_1242 0402-0103 60.1 µM -0.134056632322733 0.466310929781272 no 1816 0.446678896206917 2654 432868
SGTC_2988 9073640 71.4286 µM -0.134199016301107 0.466259430386392 no 1817 0.446622601877425 2795 9102229
SGTC_3092 9117248 49.47 µM -0.134404826704674 0.466184991048739 no 1818 0.446541232554319 2643 17141857
SGTC_1066 ketoconazole 628 nM -0.134569573468528 0.466125404825947 no 1819 0.446476099797956 2789 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W
SGTC_119 0121-0043 24.815 µM -0.135176414662863 0.46590592680399 no 1820 0.446236197146418 2631 1092378
SGTC_2968 9090663 33.37 µM -0.135853295603159 0.465661129539446 no 1821 0.445968628888425 2745 25236811
SGTC_2287 7945887 168.79 µM -0.136367330277344 0.465475235089512 no 1822 0.445765449521458 2721 1245853
SGTC_2388 9080168 200 µM -0.138357526489595 0.464755576008008 no 1823 0.444978931529288 2646 15943073
SGTC_1217 1183-1422 255 µM -0.138767815712442 0.464607228827698 no 1824 0.444816813607033 2767 2849664
SGTC_1748 st037455 53.6035 µM -0.140050674470105 0.464143420839622 no 1825 0.444309976227483 2799 580690
SGTC_2682 pyrogallin 40.03 µM -0.141036073594589 0.463787190209817 no 1826 0.443920722273441 2679 822798 An ATP competetive kinase inhibitor.
SGTC_287 k060-0039 29.6 µM -0.14271775911945 0.463179312998304 no 1827 0.443256545273799 2774 5861974
SGTC_1519 esterone 74 µM -0.144102040222041 0.46267900271229 no 1828 0.442709946837181 2653 698 A steroid.
SGTC_801 0866-0028 10.1 µM -0.147194913245382 0.461561383392924 no 1829 0.4414890877543 2649 6849771
SGTC_1208 2323-2347 50.3 µM -0.147749077721942 0.461361166134597 no 1830 0.441270399112484 2758 5412760
SGTC_3028 9087778 49.47 µM -0.150184943494875 0.460481215038525 no 1831 0.440309352256011 2678 17217395
SGTC_3332 9141069 11.198 µM -0.150870761796978 0.460233499423742 no 1832 0.440038832573972 2669 17332883
SGTC_1463 k081-0032 34.1 µM -0.152304840706702 0.459715564200991 no 1833 0.439473253565773 2732 977755
SGTC_1273 0849-0096 14.1 µM -0.152562129493101 0.459622648400455 no 1834 0.439371795799411 2716 5286025
SGTC_897 1000-0139 31.4 µM -0.152961270160845 0.459478509388963 no 1835 0.439214408869151 2807 6151020
SGTC_2348 9022543 33.42 µM -0.155617099410224 0.458519563983127 no 1836 0.438167422885613 2795 3162678 YDL140C RPO21
SGTC_544 k015-0020 52.4 µM -0.15683790778558 0.458078844974602 no 1837 0.437686298222775 2716 3008304
SGTC_1523 st012844 44.7 µM -0.158562815880899 0.457456230973281 no 1838 0.43700666335567 2825 4274103
SGTC_75 0159-0059 199.013 µM -0.159275175611686 0.457199131622534 no 1839 0.436726039032599 2978 5377270
SGTC_1749 st037932 54.2 µM -0.159779686052387 0.457017058454864 no 1840 0.436527313330874 2816 594497
SGTC_1727 st034309 9.9045 µM -0.160712581733109 0.456680408797353 no 1841 0.436159889731655 2999 870305
SGTC_1455 4262-0120 131 µM -0.162288447449887 0.45611180431902 no 1842 0.435539355842142 2878 1529587
SGTC_1149 3909-7961 23.3 µM -0.164615317729273 0.455272386731129 no 1843 0.434623386949451 2705 735261
SGTC_2626 ethyl orsellinate 100 µM -0.165556135963043 0.454933043374425 no 1844 0.434253134621586 2702 75653 A natural product.
SGTC_2550 chrysin dimethyl ether 71.87 µM -0.16604030920059 0.454758419921464 no 1845 0.434062614140037 2686 88881 An O-methylated flavonoid and antioxidant.
SGTC_2337 9009472 200 µM -0.166500647431446 0.454592400984583 no 1846 0.433881486853255 2829 5742383
SGTC_608 k048-0125 159 µM -0.166706158424384 0.454518286917628 no 1847 0.43380062981429 2786 6817652 YLR060W | YFL022C FRS1 | FRS2
SGTC_344 k064-0035 6.43 µM -0.167017763064549 0.454405914990871 no 1848 0.433678036166314 2710 5088750
SGTC_1388 3346-4487 254 µM -0.167055025003862 0.454392477707487 no 1849 0.433663376743852 2777 3345614
SGTC_417 st075190 100 µM -0.167174314610437 0.454349460215774 no 1850 0.433616446983888 2839 222757
SGTC_3106 9121286 49.47 µM -0.167268124078094 0.454315631592721 no 1851 0.433579542030368 2913 15943471
SGTC_260 nsc-65238 3.989 µM -0.167829924312949 0.454113047807574 no 1852 0.433358540097173 2819 3246252
SGTC_1897 st060201 15 µM -0.168060465855574 0.454029918544803 no 1853 0.43326785529833 2729 611878
SGTC_2888 9058547 12.99 µM -0.169202719073111 0.453618071716631 no 1854 0.432818595559111 2728 16476514
SGTC_686 1319-0111 510 µM -0.170676290793399 0.453086839581775 no 1855 0.432239153232195 2851 4562600
SGTC_2025 5147754 141 µM -0.17149892920069 0.452790309568291 no 1856 0.431915736171762 2804 315777 YLR208W SEC13
SGTC_351 caspofungin 25 nM -0.172387076237565 0.452470195731766 no 1857 0.431566615876576 2745 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1
SGTC_2571 chrysanthemic acid 100 µM -0.17267981528827 0.452364690884316 no 1858 0.43145155525097 2775 2743 An insecticide.
SGTC_701 4424-0219 185 µM -0.173233810918591 0.452165036865669 no 1859 0.431233824061957 2816 2911779
SGTC_329 k048-0121 21.3 µM -0.173974520409508 0.451898112102695 no 1860 0.430942743306209 2798 6832902
SGTC_2543 pimpinellin 60.67 µM -0.174266731203042 0.451792815933646 no 1861 0.430827921903108 2718 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo.
SGTC_1346 1488-2224 62.4 µM -0.174814620467317 0.4515953969151 no 1862 0.430612649885859 2717 3722427
SGTC_1017 4239-0030 168 µM -0.176177450580238 0.451104385139081 no 1863 0.430077267760764 2743 1149593
SGTC_1979 st071809 45.3 µM -0.176345315616774 0.451043910486088 no 1864 0.430011331552666 2847 4976333
SGTC_270 tamoxifen 5.46 µM -0.17647731536868 0.450996357372015 no 1865 0.429959484347389 2889 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen. YIL048W NEO1
SGTC_1739 st037196 92.5 µM -0.17657598705328 0.450960811204887 no 1866 0.42992072861572 2834 612214
SGTC_3101 9120531 49.47 µM -0.176970459328284 0.450818707727895 no 1867 0.429765796674237 2941 24824904
SGTC_2062 5245942 200 µM -0.177545617681333 0.450611525755706 no 1868 0.429539918309145 2682 1376160
SGTC_2443 5493264 126.67 µM -0.177609666694363 0.450588455026715 no 1869 0.429514766164276 2871 5340055
SGTC_2711 st079103 59.1 µM -0.177619166170803 0.450585033288805 no 1870 0.429511035729787 2800 54693780
SGTC_3117 9124945 49.47 µM -0.177891513530724 0.450486934573162 no 1871 0.429404087883959 2702 17592065
SGTC_203 k066-0004 30.888 µM -0.179856413616778 0.449779273356442 no 1872 0.42863264700323 2692 6795412
SGTC_2100 5377183 190 µM -0.180054934985141 0.44970778448198 no 1873 0.428554720494531 2814 2844202
SGTC_497 capsazepine 133 µM -0.180527164964995 0.449537737866512 no 1874 0.428369365080521 2738 2733484 A calcium channel blocker.
SGTC_1228 0124-0032 52.5 µM -0.183584576924646 0.448437011411948 no 1875 0.427169681650799 2795 X1228
SGTC_1516 st013856 110 µM -0.183838413106421 0.448345643283527 no 1876 0.427070110187268 2864 5281404 A mutagen and neurotoxin.
SGTC_1461 k072-0203 53.8 µM -0.18500576136988 0.447925492567986 no 1877 0.426612258331461 2705 5418714
SGTC_1420 4'-methoxyflavone 42 µM -0.187749552262539 0.44693818116937 no 1878 0.425536491918131 2747 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13
SGTC_707 0865-0008 204 µM -0.189933323512869 0.446152618977714 no 1879 0.424680689676459 2763 723043
SGTC_2684 capsaicin 100 µM -0.190524721058031 0.445939913352683 no 1880 0.424448986678852 2832 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_1189 1431-2119 7.28 µM -0.192838456728462 0.445107891216854 no 1881 0.423542742296995 2750 3107275
SGTC_296 1222-0039 74.9 µM -0.193606020248098 0.444831927671794 no 1882 0.423242191955951 2777 5984176
SGTC_3169 9102970 49.47 µM -0.195338899340506 0.444209000936729 no 1883 0.422563823153081 2737 17027839
SGTC_2510 benzyl isothiocyanate 8.31 µM -0.196435516198165 0.443814865670795 no 1884 0.422134649915321 2723 2346 DNA damaging agent; causes G2/M arrest.
SGTC_1764 st044502 93.5 µM -0.196512842541827 0.443787075888163 no 1885 0.422104390871466 2869 8407
SGTC_565 1418-0001 44.5 µM -0.197975128292173 0.443261607263183 no 1886 0.421532261660504 2911 2862145
SGTC_931 2812-0076 566 µM -0.198065184040266 0.443229249213431 no 1887 0.421497032140164 2727 3450959
SGTC_2308 7584454 197.62 µM -0.20306967102408 0.44143168155211 no 1888 0.419540288417764 2905 893577
SGTC_556 4058-0063 51.5 µM -0.204047158932722 0.441080716099038 no 1889 0.419158323282084 2780 6615692
SGTC_3119 9125183 49.47 µM -0.20482003724961 0.440803248128957 no 1890 0.418856365710995 2837 22695334
SGTC_2026 5148700 152 µM -0.206292178514961 0.440274821050006 no 1891 0.418281343891767 2760 79838
SGTC_2020 4017018 200 µM -0.209193256351759 0.439233787458054 no 1892 0.417148688309152 2871 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope.
SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM -0.209348899704301 0.439177947627849 no 1893 0.417087940473041 2805 689007
SGTC_1204 4049-0315 18.3 µM -0.209528286860531 0.439113590785785 no 1894 0.417017927849823 3033 588402
SGTC_757 1066-0008 322 µM -0.209709016684921 0.439048753876349 no 1895 0.416947393860683 2940 6842497
SGTC_767 0929-0023 86 µM -0.209879635539517 0.438987545782702 no 1896 0.416880808364136 2791 1204563
SGTC_1084 voriconazole 435 nM -0.209950283960553 0.438962201676852 no 1897 0.416853237899407 2815 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_2518 prenyletin 46.28 µM -0.211029786229962 0.438574976934689 no 1898 0.416432014326322 2883 3873459 A coumarin with calcium channel inhibitory activity.
SGTC_1035 k081-0041 55.2 µM -0.211915005355782 0.43825748672053 no 1899 0.416086671935287 2770 731709
SGTC_293 4049-0273 38.5 µM -0.214653361941303 0.437275607866638 no 1900 0.415018793348578 2812 1380311
SGTC_880 0833-0487 87.2 µM -0.215771089879984 0.436874940382167 no 1901 0.414583092211138 2795 76075
SGTC_786 4544-0069 423 µM -0.216224994811349 0.436712249349798 no 1902 0.414406185656141 2906 748821 YLR208W SEC13
SGTC_3262 9137218 49.47 µM -0.217324368614828 0.436318250324956 no 1903 0.413977783738601 2733 17650664
SGTC_2455 5377712 9.75 µM -0.218767194737686 0.43580125908283 no 1904 0.413415701339221 2875 2243908
SGTC_2470 5664817 21.68 µM -0.219787358516786 0.435435781705415 no 1905 0.413018382680857 2781 2859561
SGTC_823 0417-1665 178 µM -0.22232688682029 0.4345262266124 no 1906 0.412029711578109 2892 3429856
SGTC_154 3389-1638 511.116 µM -0.222437105781774 0.434486758501531 no 1907 0.411986814507631 2895 5238686
SGTC_204 PMA1.184 62.41 µM -0.223391861896929 0.434144898957355 no 1908 0.411615268786521 2773 2252213 YGL008C PMA1
SGTC_1245 0418-0076 17.2 µM -0.224496697895893 0.4337493633586 no 1909 0.411185418024256 2992 6790114
SGTC_3100 9120536 49.47 µM -0.224887000611091 0.43360964929909 no 1910 0.411033591151288 2748 16421196
SGTC_1274 0865-0114 173 µM -0.225278439434084 0.433469536886158 no 1911 0.41088133571909 2852 870624
SGTC_2272 7805186 180 µM -0.225538289830522 0.433376530120035 no 1912 0.410780270800791 2929 2956062 YPR165W RHO1
SGTC_290 2043-6722 48.1 µM -0.226683786408989 0.432966573131192 no 1913 0.410334817761954 2884 773758 YLR208W SEC13
SGTC_2987 9018338 71.43 µM -0.227838110494856 0.432553529870281 no 1914 0.409886048936672 2766 5055682
SGTC_1718 roemerine 11.9335 µM -0.228216133522646 0.43241828067853 no 1915 0.409739109810872 2937 235224 An aporphine alkaloid with mutagenic activity.
SGTC_571 k831-0106 44.2 µM -0.229139581136339 0.432087922645011 no 1916 0.409380215220908 2858 4783639
SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM -0.230115548075658 0.431738827737988 no 1917 0.409000991724267 2937 5024745
SGTC_1702 st027038 51 µM -0.230208480672442 0.43170558932947 no 1918 0.408964886099834 2864 5521182
SGTC_1088 bifonazole 369 nM -0.23039629659918 0.431638416286596 no 1919 0.408891919321928 2787 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase.
SGTC_2778 tioconazole 65.09 nM -0.232018250970675 0.431058400910118 no 1920 0.408261919167455 2777 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_761 k216-0224 480 µM -0.235108582306153 0.429953702308398 no 1921 0.40706222883254 3005 1340404
SGTC_2710 st078562 53.7235 µM -0.236571835713909 0.429430824806939 no 1922 0.40649448593134 2787 17250908
SGTC_573 3702-0553 84.7 µM -0.237027869058295 0.429267891567483 no 1923 0.406317584922495 2834 1222756
SGTC_2752 diclazuril 33.15 µM -0.237301248356618 0.429170223400075 no 1924 0.40621154685553 2991 456389 An antifungal agent for coccidioides. YHR062C RPP1
SGTC_215 1287-0124 461.5 µM -0.237359914643235 0.429149264701647 no 1925 0.406188792335861 2885 5560863
SGTC_2537 larixol 68.93 µM -0.237697040508316 0.429028829397293 no 1926 0.406058039613871 2773 6708759
SGTC_656 4090-1979 187 µM -0.240005833682463 0.428204211107508 no 1927 0.405162867071537 2951 22330961
SGTC_435 c-PAF 6.7 µM -0.241072685938328 0.427823275317134 no 1928 0.404749391006393 3016 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase
SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM -0.241502067394329 0.427669977115582 no 1929 0.404583007174566 2809 2333 A French combination drug.
SGTC_3326 9140064 16.379 µM -0.241877126780657 0.427536081967302 no 1930 0.404437687072809 2825 1868434
SGTC_424 splitomicin 100 mM -0.24235868922809 0.427364177764061 no 1931 0.404251120742683 2915 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_1221 2958-7315 257 µM -0.244245941625581 0.426690615139998 no 1932 0.403520173993026 2926 4562705
SGTC_2973 9094665 17.96 µM -0.244402267763063 0.426634831713994 no 1933 0.403459642802287 3056 25237061 YIL048W NEO1
SGTC_965 1291-5240 308 µM -0.244605069405374 0.426562466153621 no 1934 0.403381119233969 2956 2834598
SGTC_1912 st060209 90.8 µM -0.245015918979441 0.426415870582756 no 1935 0.403222052707717 2904 688787
SGTC_1988 st071872 53.4 µM -0.245324598338858 0.426305737136205 no 1936 0.403102553433058 2962 16414116
SGTC_1921 5740136 50 µM -0.24636938912857 0.425933009810163 no 1937 0.402698149992459 3040 1774243
SGTC_2763 lisinopril 49.32 µM -0.246519731237999 0.425879380957438 no 1938 0.402639966165315 2847 5362119 A lysine-analog of enalapril and an ACE inhibitor.
SGTC_2568 diosmetin 100 µM -0.247302972927225 0.425600011350435 no 1939 0.402336879086197 2985 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.
SGTC_2097 5376186 200 µM -0.249514566330275 0.424811373903527 no 1940 0.401481387422662 2980 742755
SGTC_2616 abietic acid 100 µM -0.250523057864572 0.42445185314703 no 1941 0.401091437749792 2961 6708678 Abietic acid is an inhibitor of 5α-reductase.
SGTC_1042 0350-0096 82 µM -0.252463451098631 0.42376029245841 no 1942 0.400341430539056 2832 3122515
SGTC_2610 ononetin 44.17 µM -0.252837397808141 0.423627043889402 no 1943 0.400196933554072 2913 259632
SGTC_538 2922-0838 53.3 µM -0.253186447815008 0.423502674651345 no 1944 0.400062069246536 3041 777039
SGTC_1666 st014829 29 µM -0.253480510381919 0.423397903780746 no 1945 0.399948459977689 2808 3858230
SGTC_1379 2144-0755 36.5 µM -0.253623045714247 0.423347122145845 no 1946 0.399893395372864 3010 5392327
SGTC_3214 9129694 49.47 µM -0.254618980828611 0.422992331922087 no 1947 0.399508698841717 3004 17158655
SGTC_1790 st045711 43.5 µM -0.255076661731288 0.422829309384264 no 1948 0.399331944657978 3016 585119
SGTC_2092 5303694 80.6725 µM -0.255642865588848 0.422627650065267 no 1949 0.3991133079826 2867 1963699
SGTC_3280 9140961 49.47 µM -0.25719314670312 0.422075605437247 no 1950 0.398514837123563 2829 4901226
SGTC_3109 9122853 49.47 µM -0.258958932214418 0.421447007664235 no 1951 0.397833463603281 2904 1234709
SGTC_1075 aripiprazole 15.2 µM -0.259542678693197 0.421239245087397 no 1952 0.397608278501093 2862 60795 An atypical antipschotic. YIL048W NEO1
SGTC_820 1582-0060 59.9 µM -0.260621340784375 0.420855393673852 no 1953 0.3971922653623 2918 3848840
SGTC_334 1502-1024 68.5 µM -0.260647987744794 0.420845912068799 no 1954 0.39718198977064 2950 3296216
SGTC_259 usnic acid 108.925 µM -0.261554529591771 0.420523370891894 no 1955 0.396832451976482 3065 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_702 1488-0190 94 µM -0.263588471345958 0.419799903256501 no 1956 0.396048521490967 2960 949357
SGTC_555 4296-0685 37 µM -0.264872547808213 0.419343300070296 no 1957 0.395553823451915 2901 2908540 YHR072W ERG7
SGTC_677 0929-0063 136 µM -0.265651970151579 0.419066199150123 no 1958 0.395253628389884 2886 1539583
SGTC_2155 5570423 76 µM -0.26688720990578 0.418627127894104 no 1959 0.394778002298323 2898 797402
SGTC_399 oxolinic acid 75 µM -0.267088241026334 0.418555680097769 no 1960 0.394700610565242 2870 4628 A DNA gyrase inhibitor.
SGTC_2787 5284540 71.43 µM -0.267372851444249 0.41845453225874 no 1961 0.394591050091142 2949 736958
SGTC_631 k072-0230 41.5 µM -0.267404632920756 0.418443237758416 no 1962 0.394578816363266 2984 5773147
SGTC_2105 5350118 200 µM -0.268275588554245 0.418133743768798 no 1963 0.394243597610144 2911 2133313
SGTC_1049 3226-0134 66 µM -0.268626043140536 0.41800922405959 no 1964 0.394108734580049 2884 5702385
SGTC_2400 5203494 178.7 µM -0.269913115651025 0.41755198607222 no 1965 0.393613548358833 2831 6777674
SGTC_1396 3511-0007 98.6 µM -0.270110841670421 0.417481752923039 no 1966 0.393537490788113 2994 X1396
SGTC_2634 4'-methoxyflavone 100 µM -0.270318005099976 0.41740817038831 no 1967 0.393457807367292 2956 77793 From seeds of Psoralea corylifolia (Fabaceae)
SGTC_3348 9149464 3.537 µM -0.27197966700897 0.416818068290806 no 1968 0.39281882679853 2851 1951442
SGTC_590 k048-0076 22.4 µM -0.275664943510559 0.415509995127757 no 1969 0.391402711846075 3007 6832814
SGTC_1406 3909-7906 11.9 µM -0.276046711220603 0.415374541552704 no 1970 0.391256094577375 2938 X1406
SGTC_352 k048-0007 5.11 µM -0.277424606605905 0.414885739400837 no 1971 0.390727044753627 2986 6811911
SGTC_2054 5233173 129 µM -0.278261276275595 0.414588998856498 no 1972 0.39040589985382 3063 6889
SGTC_2899 9053889 58.44 µM -0.279034471671656 0.414314813976155 no 1973 0.390109185199265 2999 6470052
SGTC_415 dibenzyl ketone 100 µM -0.279638168901528 0.414100764310768 no 1974 0.389877560158618 2974 7593
SGTC_3251 9135047 49.47 µM -0.280445696331953 0.4138144835724 no 1975 0.38956779120031 2994 17682963
SGTC_3167 9103034 49.47 µM -0.281380296377021 0.413483210846918 no 1976 0.389209364543355 2876 5127859
SGTC_668 1682-0499 62.6 µM -0.28226905502225 0.413168243903039 no 1977 0.388868605853957 2948 682214
SGTC_2929 9013348 24.6 µM -0.285053824488536 0.412181712918909 no 1978 0.38780145285206 3011 2995952
SGTC_901 1112-0062 60.1 µM -0.285333059361295 0.412082821812802 no 1979 0.387694493692027 2915 1908457
SGTC_489 paxilline 115 µM -0.285759992685684 0.411931634054519 no 1980 0.387530976047416 2978 105008 A toxic potassium channel blocker.
SGTC_743 1275-0778 158 µM -0.286776304162017 0.41157178540048 no 1981 0.387141803873085 3014 2849257 YMR203W TOM40
SGTC_1970 st070122 35.8 µM -0.286817861811304 0.411557072531329 no 1982 0.387125892776153 3091 102928
SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM -0.286938091492109 0.411514507697073 no 1983 0.387079861738543 3043 756377
SGTC_208 k072-0098 12.366 µM -0.290489902751445 0.410257534190094 no 1984 0.38572073717912 2911 5948901
SGTC_2363 9053361 176 µM -0.291265285092713 0.409983251193345 no 1985 0.385424217731232 3084 6469797 YMR079W SEC14
SGTC_2140 5586273 200 µM -0.292790350917962 0.409443904495869 no 1986 0.384841202036217 2914 854421
SGTC_692 k241-0027 77.8 µM -0.293953183476402 0.409032778372647 no 1987 0.384396838907012 3091 3600480
SGTC_1175 0741-0056 27.6 µM -0.294703463759462 0.408767565548852 no 1988 0.384110208469507 3117 765927
SGTC_953 1188-0045 9.7 µM -0.295254835886121 0.40857269039387 no 1989 0.383899607531641 3038 6144426
SGTC_758 0868-0029 16 µM -0.297326444684612 0.407840710166908 no 1990 0.383108647044358 3039 762687
SGTC_742 0kpi-0133 140 µM -0.297883529278016 0.407643925199841 no 1991 0.382896029668569 3093 2728852
SGTC_1137 ixabepilone 100 µM -0.297999270318001 0.407603043672445 no 1992 0.382851860270007 2905 154225 A novel microtubule stabilizer.
SGTC_1792 st045773 43.6 µM -0.298580227436453 0.407397855832417 no 1993 0.382630176919519 2914 2919270
SGTC_3045 9092950 49.47 µM -0.299207208803669 0.407176441225493 no 1994 0.382390974641064 3076 44120432
SGTC_469 w7 172 µM -0.299970358009257 0.40690697981117 no 1995 0.382099882955407 2955 45115570 A P450 inhibitor.
SGTC_1830 st055982 50.3 µM -0.300189508135103 0.406829607926356 no 1996 0.382016303772318 3053 455313 An antimicrobial agent.
SGTC_1298 1079-1278 263 µM -0.302006121759403 0.406188385032447 no 1997 0.381323698118161 2957 2840950
SGTC_3317 9138495 8.753 µM -0.302419025447617 0.40604267453487 no 1998 0.381166326562516 2941 17020139
SGTC_2753 fluvastatin 17.09 µM -0.302599130920158 0.405979120790655 no 1999 0.381097688431074 3026 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5
SGTC_3247 9135149 49.47 µM -0.302878614791789 0.405880504337608 no 2000 0.380991184633995 2926 8934436 YOR116C RPO31
SGTC_2460 5552655 174.22 µM -0.304282655148738 0.405385176325073 no 2001 0.3804562791212 3070 5401989
SGTC_1741 st038134 10.228 µM -0.304486213828221 0.405313375904667 no 2002 0.380378747114728 3178 1272587
SGTC_315 k915-0449 187 µM -0.305421967307469 0.404983352435868 no 2003 0.380022396542432 2983 20970215 YNL149C PGA2
SGTC_2938 9059746 27.26 µM -0.305644449145256 0.404904897014945 no 2004 0.379937686711329 3065 6471769
SGTC_326 k292-0812 17.5 µM -0.306373491572779 0.404647836175187 no 2005 0.379660144611802 3020 3579357
SGTC_948 3448-0295 75.3 µM -0.306617421967199 0.40456183533965 no 2006 0.379567295599714 2924 678569
SGTC_370 0180-0345 38.7 µM -0.308010618153483 0.404070734378309 no 2007 0.379037126378336 2864 3989527
SGTC_2329 6138490 200 µM -0.308976991937991 0.403730176836803 no 2008 0.378669514421185 3165 720019
SGTC_958 1222-0007 33 µM -0.309080190187111 0.403693813289295 no 2009 0.378630263927647 3124 7312461
SGTC_2340 7987427 183.45 µM -0.309503155438443 0.403544783444023 no 2010 0.378469406115865 3074 2239331
SGTC_1093 fluphenazine 7.97 µM -0.309624024532821 0.403502198350872 no 2011 0.378423442287217 2954 6602611 An atypical antipsychotic.
SGTC_80 0159-0065 512.242 µM -0.311236402683969 0.402934228311874 no 2012 0.377810455494252 2905 1548079
SGTC_16 erodoxin 22.806 µM -0.311337645381899 0.402898571773623 no 2013 0.377771975739788 3059 3967339 Erodoxin inhibits Ero1. YML130C ERO1
SGTC_2002 4023503 131 µM -0.311873237001323 0.402709955878279 no 2014 0.377568431281935 3091 4736863 YCR052W RSC6
SGTC_551 k048-0028 34.9 µM -0.312358569031806 0.402539059135847 no 2015 0.377384016670607 3101 6836383
SGTC_3207 9114163 49.47 µM -0.31249464076374 0.402491148442412 no 2016 0.377332317669429 3217 849233
SGTC_486 niguldipine 82 µM -0.313143080502791 0.402262853719962 no 2017 0.377085980129974 2956 1236 A calcium channel blocker.
SGTC_695 3505-6186 243 µM -0.31335671891192 0.402187645821776 no 2018 0.377004831401566 3062 1819379
SGTC_1454 4239-0054 42.6 µM -0.313374340713727 0.402181442517071 no 2019 0.376998138152853 3136 1340767
SGTC_861 0443-0273 110 µM -0.313432467308146 0.402160980710584 no 2020 0.376976060323369 3049 6149169
SGTC_2093 5331342 194.4 µM -0.313439280527062 0.402158582329119 no 2021 0.376973472531047 3102 33839
SGTC_816 0325-0417 81.3 µM -0.313727848637088 0.402057004299094 no 2022 0.376863873856703 3002 68101
SGTC_983 1491-0821 12.2 µM -0.314034940818444 0.401948912929555 no 2023 0.376747250605292 3084 46495113
SGTC_1649 st011737 51.3 µM -0.316975246911225 0.400914354598072 no 2024 0.375631192308991 3017 1761035
SGTC_2915 7971052 15.16 µM -0.318467857271173 0.400389439037331 no 2025 0.375065036298828 3029 5741558
SGTC_213 1246-0773 967 nM -0.318575475055108 0.400351599363094 no 2026 0.37502422661701 2997 6251622
SGTC_780 0109-0199 192 µM -0.319244999933313 0.400116207591987 no 2027 0.3747703678939 3154 610414
SGTC_2891 9063876 19.48 µM -0.319781497865932 0.399927611659169 no 2028 0.374566987150309 3063 6472478
SGTC_2152 5568786 200 µM -0.32118662108629 0.399433777281318 no 2029 0.374034485148931 2988 5399883
SGTC_443 clozapine 122 µM -0.322547436335532 0.398955668378539 no 2030 0.373519003629691 3031 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_60 0986-0278 202 µM -0.322676527142227 0.398910321467221 no 2031 0.373470115319848 2967 3110598
SGTC_858 0438-0351 2.77 µM -0.322724028579215 0.398893635545277 no 2032 0.373452126441543 3004 2799119
SGTC_2398 5228213 48.84 µM -0.323028563600904 0.398786665328081 no 2033 0.373336805042291 3186 80771 YMR134W ERG29
SGTC_2342 7990637 118.86 µM -0.324166356995673 0.398387074161939 no 2034 0.37290604559499 3085 2033102 YER133W GLC7
SGTC_3258 9138477 49.47 µM -0.32487494918689 0.398138271551479 no 2035 0.372637858515899 3013 4970355
SGTC_1961 st076550 68.7 µM -0.324948884245445 0.398112313678351 no 2036 0.372609879222627 3081 1579337
SGTC_1270 0831-1170 17.3 µM -0.325623383325075 0.397875524509765 no 2037 0.372354659143956 2970 6764716
SGTC_2547 epiafzelechin trimethyl ether 100 µM -0.326817293019497 0.397456483684582 no 2038 0.371903039550771 2923 6708630 An antioxidant.
SGTC_1558 st069300 45.6 µM -0.328899952262223 0.396725791223165 no 2039 0.371115655198633 3095 24208000
SGTC_1050 3232-1156 69.3 µM -0.330385184796529 0.396204924738828 no 2040 0.370554467234625 3037 700529
SGTC_3078 9116413 49.47 µM -0.331620757423361 0.395771754313288 no 2041 0.370087821797621 2908 17177322
SGTC_2667 digitoxin 100 µM -0.331936215782278 0.395661180663156 no 2042 0.369968711531531 3063 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_1631 benzylvanillin 81.9 µM -0.332073546838671 0.395613046358639 no 2043 0.369916862185268 3128 75506
SGTC_354 2783-3500 4.88 µM -0.333694146156693 0.395045149463776 no 2044 0.369305183664846 3014 6740761
SGTC_1131 3454-3128 32.3 µM -0.334513165437019 0.394758230156697 no 2045 0.368996178979277 3139 710982
SGTC_798 1287-0182 476 µM -0.335199915614901 0.394517691421051 no 2046 0.368737142841005 3185 1649755
SGTC_1845 st056753 3.01 µM -0.335284690794339 0.394488001147311 no 2047 0.368705170519669 2939 5375839
SGTC_3190 9110366 49.47 µM -0.335342296302467 0.394467826685081 no 2048 0.368683445554073 3104 17123768
SGTC_3229 9132204 49.47 µM -0.335659080733656 0.394356888264832 no 2049 0.36856398304126 2997 17682924
SGTC_2085 5307070 144.047 µM -0.338115343376033 0.393496992566613 no 2050 0.367638134212216 2967 2840351
SGTC_455 paf C-16 10 µM -0.338157709870936 0.393482165321599 no 2051 0.367622171569745 2988 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis.
SGTC_955 1216-0110 33 µM -0.340288014175653 0.392736810107168 no 2052 0.366819821234907 2961 3619719
SGTC_3026 9090633 49.47 µM -0.340536422402093 0.392649922075177 no 2053 0.366726299422902 2990 25236842
SGTC_874 0599-0792 117 µM -0.340801849677245 0.392557087046079 no 2054 0.366626378947796 3174 765305
SGTC_1157 4092-0394 27.6 µM -0.341485564396239 0.3923179812503 no 2055 0.366369035211056 3193 3659885
SGTC_722 3534-0461 190 µM -0.342252247567916 0.392049908429894 no 2056 0.366080534395733 3037 658262
SGTC_1309 pyrazolanthrone 13.4 µM -0.344042695349332 0.391424073305328 no 2057 0.365407088755574 3112 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14
SGTC_916 4466-0038 42 nM -0.344269685021214 0.39134475111486 no 2058 0.365321740138901 3226 5722064 YGL116W CDC20
SGTC_3159 9100096 49.47 µM -0.344534089478252 0.391252359917902 no 2059 0.365222331889789 2916 25236875
SGTC_2508 celastrol 40.54 µM -0.34473757533206 0.391181259766387 no 2060 0.365145833398051 3043 122724 Celastrol is a natural product and antioxidant.
SGTC_2486 5283202 22.39 µM -0.345434445073907 0.390937793528879 no 2061 0.364883892792671 3048 1377751
SGTC_1794 st048918 76.9 µM -0.345765159994237 0.390822266199602 no 2062 0.364759605148857 3093 672303
SGTC_3299 9121982 43.1275 µM -0.34632309894252 0.390627385447926 no 2063 0.364549955514338 3028 17594604 YPL160W CDC60
SGTC_2541 muurolladie-3-one 83.07 µM -0.347019045989199 0.390384338787021 no 2064 0.36428850510981 3176 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils. YMR203W TOM40
SGTC_2315 7733312 200 µM -0.347912260630866 0.390072462833748 no 2065 0.363953038589951 3009 726316
SGTC_81 0411-0046 9.971 µM -0.348369135960074 0.389912967000733 no 2066 0.363781489230173 3065 12925265
SGTC_2921 7974240 10.71 µM -0.348708883221853 0.38979437275827 no 2067 0.363653937279808 3145 2979074 YDR527W RBA50
SGTC_1641 st009299 47.1 µM -0.350470550745006 0.389179599145624 no 2068 0.362992793745169 3101 4046054
SGTC_1883 5-benzylidenerhodanine 20 µM -0.35088034513041 0.389036631853491 no 2069 0.36283905874214 3135 1273210
SGTC_653 0203-0016 55.2 µM -0.352064284273761 0.388623668751313 no 2070 0.362395026384861 3075 295302
SGTC_633 0437-0093 97.7 µM -0.354181860560839 0.387885363069091 no 2071 0.361601298408147 3039 2831118
SGTC_1105 epirubicin 18.1 µM -0.355333371475811 0.387484051744715 no 2072 0.361169928864078 3019 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_1708 st033234 31.827 µM -0.356154741391871 0.387197870775796 no 2073 0.360862341825017 3146 674664
SGTC_978 1416-0512 87.4 µM -0.356425518662672 0.387103540229593 no 2074 0.36076096071929 3111 6814003
SGTC_714 4296-0578 26.1 µM -0.356955262365442 0.386919012958495 no 2075 0.360562648877725 3022 1589775
SGTC_1144 3486-0183 12.5 µM -0.357172957704029 0.386843189871252 no 2076 0.360481164555887 3050 6744069
SGTC_869 0564-0080 44.1 µM -0.357516224557849 0.386723639114935 no 2077 0.360352691136713 3071 6843321
SGTC_493 zm226600 134 µM -0.358509110905211 0.386377903634471 no 2078 0.359981175445938 3206 5240098 A potassium channel opener. YCR052W RSC6
SGTC_177 1327-0068 8.361 µM -0.358847437807957 0.386260114550866 no 2079 0.359854611332376 3139 15389900 YOR207C | YLR033W RET1 | RSC58
SGTC_684 1140-0066 328 µM -0.360190249648296 0.385792715793888 no 2080 0.359352432857276 3104 6813534
SGTC_2635 hydroquinidine 100 µM -0.360212642076395 0.385784922960686 no 2081 0.359344060698275 3001 442912 An experimental heart treatment.
SGTC_1394 3474-0001 65.7 µM -0.360223023861573 0.385781309990728 no 2082 0.359340179143189 3068 5017666 YIL048W NEO1
SGTC_1879 gemcitabine 100 µM -0.360924901960914 0.385537072056966 no 2083 0.359077793747498 3050 60750 A nucleoside analog which inhibits DNA replication.
SGTC_1354 1498-1681 81 µM -0.361009537019889 0.385507624007139 no 2084 0.359046158833336 3131 5754243
SGTC_1054 3429-0080 167 µM -0.361260542872337 0.385420292534916 no 2085 0.358952343485898 3216 1162877
SGTC_137 0438-0332 85.389 µM -0.361445533447971 0.385355933214764 no 2086 0.358883207295184 3149 2063393 YER012W | YPR107C PRE1 | YTH1
SGTC_2927 9011802 47.9 µM -0.362081711315062 0.385134627263628 no 2087 0.358645484995974 3139 43912568
SGTC_585 0kpi-0023 191 µM -0.36227402625656 0.385067734400676 no 2088 0.358573632926873 3168 64601
SGTC_365 0121-0052 13.6 µM -0.362436673623507 0.385011163472871 no 2089 0.358512869065293 3157 3101739
SGTC_2768 sulfasalazine 50.2 µM -0.36436144148883 0.384341889653639 no 2090 0.357794062315443 3189 5384001 An antioxidant and salicylic acid derivative.
SGTC_169 k015-0017 16.025 µM -0.364600211571454 0.384258889311329 no 2091 0.357704928443403 3284 1840002
SGTC_1485 3909-9022 254 µM -0.365571100789722 0.383921447216704 no 2092 0.357342571399086 3127 714516
SGTC_2601 securinine 100 µM -0.36639333344671 0.383635740971208 no 2093 0.357035796778376 3030 442872 A GABA receptor antagonist.
SGTC_769 0302-0231 76 µM -0.367083995464176 0.383395801258776 no 2094 0.356778182503185 3162 571869 YER009W NTF2
SGTC_133 0724-0033 378.92 µM -0.367375171119118 0.383294658658983 no 2095 0.356669594667538 2961 280309
SGTC_719 2810-4230 27.3 µM -0.367942657515015 0.383097559789683 no 2096 0.356457995938478 3075 721079
SGTC_1345 1488-0192 31.4 µM -0.36821700643511 0.383002284014974 no 2097 0.356355715257334 3198 658348
SGTC_116 0155-0182 31.788 µM -0.368520932394986 0.382896745002311 no 2098 0.356242419951786 3064 771486
SGTC_3010 9080089 71.4286 µM -0.368924810732334 0.382756510742123 no 2099 0.356091884762856 3154 17027233
SGTC_2487 5918373 44.05 µM -0.369070944539944 0.382705774083121 no 2100 0.356037422695821 3195 2876279
SGTC_476 mead acid 10 µM -0.371376424216498 0.381905594214048 no 2101 0.35517859138525 3045 5312531 An omega 9 fatty acid.
SGTC_2759 disulfiram 3.38 µM -0.374931584312504 0.380672667903944 no 2102 0.353855674375507 3023 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_379 3970-0972 5.9 µM -0.374980712641005 0.380655638697844 no 2103 0.353837405455903 3115 2898042 YBL034C STU1
SGTC_1885 st057546 99.9 µM -0.375016807661246 0.380643127335894 no 2104 0.353823983332523 3236 702008
SGTC_1494 4358-1428 177 µM -0.376057875454447 0.380282323129473 no 2105 0.353436935040745 3204 1564571
SGTC_2736 butenafine 14.65 µM -0.376329820075114 0.380188092073915 no 2106 0.353335856382962 3076 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_975 1335-0046 28.5 µM -0.377716044330562 0.379707864547814 no 2107 0.352820773812124 3088 16486740
SGTC_3267 9137951 49.47 µM -0.378639070820057 0.379388204724414 no 2108 0.352477952197712 3015 16643986
SGTC_2228 7354201 200 µM -0.381107694436872 0.378533683846082 no 2109 0.351561669086541 3096 753451
SGTC_2389 9091542 195.52 µM -0.382959316606409 0.377893129056586 no 2110 0.350874964683573 3120 3626624 YOL127W RPL25
SGTC_2824 7998404 51.95 µM -0.384868237601591 0.377233103480318 no 2111 0.350167519688766 3048 837851
SGTC_2522 biochanin a 4.94 µM -0.385275992197756 0.377092165279687 no 2112 0.35001647334418 3206 5280373 A possible chelator.
SGTC_1439 4092-1168 46 µM -0.385323669467118 0.377075686954665 no 2113 0.349998813590664 3152 2886240
SGTC_3042 9091578 49.47 µM -0.38551644922003 0.377009060265978 no 2114 0.34992741090271 3182 25236497
SGTC_1776 st049249 45.9 µM -0.386496038847174 0.37667056051596 no 2115 0.34956466784316 3130 1822314
SGTC_2533 agelasine 13.65 µM -0.387904916216487 0.376183885539783 no 2116 0.349043199918901 3290 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase.
SGTC_3302 9125395 16.351 µM -0.388488144841705 0.375982475756044 no 2117 0.348827412782078 3111 17599668
SGTC_2799 7812892 81.82 µM -0.389264001627971 0.375714596914462 no 2118 0.348540431471211 3238 20205235
SGTC_588 3970-1144 52.9 µM -0.390139555955287 0.375412367599907 no 2119 0.348216677168157 3183 1888707
SGTC_2327 6189656 200 µM -0.390267457830617 0.375368224026613 no 2120 0.348169392058063 3186 5349088
SGTC_440 fluspirilene 35.1 µM -0.390663533266849 0.375231534390707 no 2121 0.348022978603758 3291 3396 An atypical antipsychotic.
SGTC_112 phenothiazine 287.218 µM -0.391216875215652 0.375040596725902 no 2122 0.34781846786282 3235 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.
SGTC_1363 1636-0063 10.4 µM -0.392479879147988 0.374604895956428 no 2123 0.347351837667488 3114 6072185
SGTC_3181 9108277 49.47 µM -0.393338936208754 0.374308636888641 no 2124 0.347034582026853 3091 17097298
SGTC_3307 9126885 69.2785 µM -0.393377995719733 0.374295168376591 no 2125 0.347020159628619 3083 24824909
SGTC_121 0557-0495 61.343 µM -0.393813162614932 0.374145124379063 no 2126 0.346859492878502 3119 3104427
SGTC_637 1181-0519 7.26 µM -0.394445411565914 0.373927161163802 no 2127 0.346626111080245 3132 6252091 YGR060W ERG25
SGTC_1287 0971-0001 34.6 µM -0.395476881310245 0.373571656034659 no 2128 0.346245490024383 3133 4665869
SGTC_971 1315-0384 26.7 µM -0.395523760313983 0.373555501326334 no 2129 0.346228194960976 3113 6769120
SGTC_156 3474-0145 5.642 µM -0.396054087640433 0.373372763706619 no 2130 0.346032563725832 3220 2265471
SGTC_3006 9075424 71.4286 µM -0.396807709590891 0.373113133297011 no 2131 0.345754632534888 3116 7465181
SGTC_1340 1486-1359 257 µM -0.397189290350338 0.372981696814948 no 2132 0.345613939554146 3118 4309068
SGTC_2224 6650123 117.647 µM -0.397473702336287 0.372883739983737 no 2133 0.345509087626005 3144 2908370
SGTC_330 1488-0319 80.1 µM -0.397602155988774 0.372839500826387 no 2134 0.345461735514041 3177 6846614
SGTC_903 1134-0042 114 µM -0.398934414101311 0.372380773034545 no 2135 0.344970765427869 3115 701009
SGTC_1310 1188-0297 994 nM -0.399388559630506 0.372224441385997 no 2136 0.344803461144794 3127 1588352
SGTC_2804 7954240 19.48 µM -0.399433588214053 0.372208942231293 no 2137 0.344786874558041 3223 828705
SGTC_3083 9117465 49.47 µM -0.399801431287426 0.372082335817235 no 2138 0.344651388221056 3189 16420915
SGTC_69 0096-0274 206.684 µM -0.399827011790623 0.372073531881789 no 2139 0.344641966985638 3378 6741392
SGTC_1065 prochlorperazine maleate 2.48 µM -0.400322163195601 0.371903130862109 no 2140 0.344459622950642 3177 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine.
SGTC_1401 3807-4679 7.6 µM -0.400634575367536 0.371795630486351 no 2141 0.344344592902651 3157 3291456
SGTC_2253 7938677 135.83 µM -0.401360492819467 0.371545882414947 no 2142 0.344077365967181 3265 2301972
SGTC_2394 5221648 200 µM -0.402291715005283 0.371225579503772 no 2143 0.34373467563105 3215 788586
SGTC_1336 1486-0901 104 µM -0.402823079214126 0.371042851569761 no 2144 0.343539190776433 3160 5006114
SGTC_2223 6903751 107.57 µM -0.404371152678157 0.370510658909896 no 2145 0.34296990498504 3185 5598863
SGTC_3005 9076496 71.4286 µM -0.404932763661771 0.370317650929702 no 2146 0.342763467163149 3230 21368410
SGTC_1348 1493-0373 93.8 µM -0.405111869972279 0.370256104603581 no 2147 0.342697640862123 3163 3010129
SGTC_2945 9067681 61.76 µM -0.406033398624306 0.369939492128228 no 2148 0.342359030278633 3186 16456930
SGTC_1092 toremifene 6.32 µM -0.406129983410609 0.369906313290711 no 2149 0.342323548065454 3110 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_1926 methyl fluorone black 53.6 µM -0.407205122618862 0.36953704655135 no 2150 0.34192866976967 3124 72721 Reacts with homocysteine.
SGTC_2175 5807670 165.306 µM -0.409412299116336 0.368779348219914 no 2151 0.341118557639256 3238 241186
SGTC_2317 5986382 200 µM -0.410854223828869 0.36828462713253 no 2152 0.34058971503416 3181 877883
SGTC_2031 5180455 200 µM -0.411193174650529 0.368168365537695 no 2153 0.340465446322543 3114 29949
SGTC_2611 pyromycin 23.93 µM -0.411512827334823 0.368058734347963 no 2154 0.340348268707342 3145 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release.
SGTC_2869 9037858 32.47 µM -0.413362672938234 0.367424504602964 no 2155 0.339670459152056 3078 27187042
SGTC_2279 7948423 32.93 µM -0.413501114833508 0.367377053554832 no 2156 0.339619752900412 3312 1247112
SGTC_1677 st019204 53.9 µM -0.413538584718097 0.367364211076123 no 2157 0.339606029537995 3205 3945625
SGTC_1676 st018489 23.4 µM -0.414564918403699 0.367012501817211 no 2158 0.339230217091499 3130 3696235
SGTC_1285 0929-0069 65.5 µM -0.419449036508112 0.36534032088999 no 2159 0.337443996522104 3171 1206237
SGTC_1490 4089-0339 670 nM -0.419718807207699 0.365248033417662 no 2160 0.337345442143003 3249 742542
SGTC_749 1000-0129 128 µM -0.420889824018777 0.364847523782253 no 2161 0.336917768118434 3305 708470
SGTC_1613 st002381 52.1 µM -0.421652611616066 0.36458671543455 no 2162 0.336639299230119 3238 551167
SGTC_1920 st075728 45.7 µM -0.421808067431485 0.364533570477991 no 2163 0.336582558359551 3300 3400306
SGTC_1887 st057648 70.8 µM -0.424394353197371 0.363649791686309 no 2164 0.335639119105503 3246 688672
SGTC_2707 st078556 66.6 µM -0.425830040034111 0.363159505179568 no 2165 0.335115847918257 3201 17250899
SGTC_171 k064-0041 9.68 µM -0.427367338621686 0.362634766801645 no 2166 0.33455589642739 3154 53325
SGTC_1161 k007-0610 110 µM -0.427773398136606 0.362496206288115 no 2167 0.334408053118596 3279 5843850
SGTC_2622 2-methoxyxanthone 59.94 µM -0.428757897197468 0.36216033846563 no 2168 0.334049710829113 3159 71034 A hepatoprotective.
SGTC_1615 st002656 86.5 µM -0.429051604907729 0.362060158836249 no 2169 0.333942835082707 3252 1584458
SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM -0.429605732963527 0.361871179171507 no 2170 0.333741233031444 3148 4000243
SGTC_414 piperonyl butoxide 100 µM -0.432093233499168 0.361023258232676 no 2171 0.332836826192167 3151 5794 A potent inhibitor of cytochrome P450.
SGTC_837 0091-0265 12.5 µM -0.432316348505116 0.360947237718652 no 2172 0.332755753325831 3163 759367
SGTC_2850 9015429 58.44 µM -0.432722767083259 0.360808775496998 no 2173 0.332608093893909 3202 6457570
SGTC_1001 4048-4355 44.4 µM -0.433614738267993 0.360504954958521 no 2174 0.332284115222817 3128 21824233
SGTC_127 0180-0333 59.125 µM -0.433740909870054 0.360461985871124 no 2175 0.332238297721625 3243 771601
SGTC_1263 0774-1208 64.8 µM -0.435532978832193 0.35985186812664 no 2176 0.331587803251019 3342 906585
SGTC_2703 st077852 53.4 µM -0.436201341341844 0.359624412476265 no 2177 0.331345327413443 3269 6281836
SGTC_2737 bleomycin 30.5 nM -0.437527009209404 0.359173411292143 no 2178 0.330864596387465 3246 16211318 Bleomycin acts by induction of DNA strand breaks.
SGTC_1450 4112-4260 37.6 µM -0.437685548241574 0.359119488361164 no 2179 0.330807123537539 3299 1633175
SGTC_3343 9148379 18.9835 µM -0.438336543919222 0.358898098535333 no 2180 0.330571169361485 3319 1955036
SGTC_1567 st069303 68.4 µM -0.43974673549141 0.358418684883871 no 2181 0.330060274683086 3258 5581319
SGTC_2828 7998861 71.43 µM -0.439818194007604 0.35839439752912 no 2182 0.330034394585335 3262 2988188
SGTC_503 tyrphostin 8 294 µM -0.440660103692449 0.358108292017876 no 2183 0.329729541816559 3248 92970 A tyrosine kinase inhibitor. YOR207C RET1
SGTC_1810 st050138 53 µM -0.441007555215511 0.357990241051188 no 2184 0.329603763698928 3280 3444541
SGTC_1475 4092-1048 11.7 µM -0.442049708751578 0.357636237934941 no 2185 0.329226617758335 3283 2881759
SGTC_2648 atorvastatin 78.68 µM -0.442801202022948 0.357381043481586 no 2186 0.328954766910694 3283 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11
SGTC_3244 9134489 49.47 µM -0.443509311448499 0.357140639798272 no 2187 0.328698692825773 3254 16584271
SGTC_36 0335-0881 14.2 µM -0.444023571745969 0.356966083577255 no 2188 0.32851277092761 3220 23828853
SGTC_510 ag-490 170 µM -0.446584728823731 0.356097192299857 no 2189 0.327587461892794 3310 5328779
SGTC_247 mechlorethamine 29.705 µM -0.44831778241796 0.355509664498478 no 2190 0.326961934408563 3189 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links.
SGTC_821 1114-0266 29.2 µM -0.453996006302851 0.353587083076453 no 2191 0.324915850633109 3270 3123235
SGTC_183 3914-0051 30.55 µM -0.455429335979284 0.353102361624583 no 2192 0.324400197119887 3326 1596232
SGTC_1855 st056195 39.6 µM -0.456281778839687 0.352814196605217 no 2193 0.324093682492189 3339 4028379
SGTC_777 1315-0167 517 µM -0.457491647829941 0.352405350023622 no 2194 0.323658852103351 3259 4221767
SGTC_2005 4024620 188 µM -0.457910257608287 0.352263930432378 no 2195 0.323508458549683 3239 236743
SGTC_814 3342-0569 96 µM -0.459201190853451 0.351827941142763 no 2196 0.323044847744878 3335 4346283
SGTC_458 nppb 133 µM -0.459444882362312 0.351745660592483 no 2197 0.322957362009458 3375 4549 A chloride channel blocker.
SGTC_3227 9130768 49.47 µM -0.459570339046354 0.351703303822227 no 2198 0.322912326629775 3260 17720899
SGTC_696 1560-0013 611 µM -0.459720626924758 0.351652565950793 no 2199 0.322858380976163 3388 1650269
SGTC_387 norethindrone acetate 66.7 µM -0.459880073566253 0.351598738928148 no 2200 0.322801151870164 3230 541197
SGTC_3150 9097574 49.47 µM -0.461489672460503 0.351055526963243 no 2201 0.322223664600329 3322 17217476
SGTC_2454 5-benzylidenerhodanine 10.36 µM -0.461653215411629 0.351000351035123 no 2202 0.322165013107917 3351 1273210
SGTC_1957 st077035 62.4 µM -0.461687383264139 0.350988823921989 no 2203 0.322152760032609 3327 705593
SGTC_678 1218-2179 85.9 µM -0.461861335711778 0.35093014019615 no 2204 0.322090381221092 3275 6820081 YOR116C RPO31
SGTC_506 n9-isopropylolomoucine 153 µM -0.461909953083129 0.350913739519108 no 2205 0.322072948077566 3322 6610355
SGTC_1211 1056-0033 32.3 µM -0.463269368282574 0.350455264361136 no 2206 0.321585649663636 3328 6741922
SGTC_1793 st048256 72.231 µM -0.463861526191642 0.350255621766004 no 2207 0.321373479559488 3266 672022
SGTC_509 pifithrin 175 µM -0.464130247985648 0.350165037419347 no 2208 0.321277215792728 3335 4817 A p53 inhibitor.
SGTC_698 k064-0052 127 µM -0.464627509606567 0.349997436286577 no 2209 0.321099114245973 3343 5088751
SGTC_1878 temozolomide 1 mM -0.465945139658305 0.349553472811967 no 2210 0.320627384752281 3322 5394 DNA alkylating agent.
SGTC_844 0330-0132 15.3 µM -0.466927496858163 0.349222610287674 no 2211 0.320275875861288 3347 2828079
SGTC_2301 7769476 200 µM -0.467074815944933 0.349173002398667 no 2212 0.320223175763102 3255 977820
SGTC_864 0469-0573 172 µM -0.469242699804367 0.348443292579634 no 2213 0.319448083715533 3228 689425
SGTC_2478 5763493 32.33 µM -0.469815958146786 0.348250427389483 no 2214 0.319243256036571 3213 1365576 YLR208W SEC13
SGTC_2367 9070478 135.38 µM -0.471393787197248 0.347719790405816 no 2215 0.318679775904125 3264 572802
SGTC_1036 k216-0215 33.5 µM -0.471929464517005 0.347539705432253 no 2216 0.31848856805011 3270 622330
SGTC_1445 4239-0156 97.7 µM -0.471985361692207 0.347520915799997 no 2217 0.318468618563431 3383 4008346
SGTC_810 3825-7150 143 µM -0.472090625454106 0.347485532786123 no 2218 0.318431051760819 3382 22330411 YGL099W LSG1
SGTC_234 nsc-17383 10.7 µM -0.472518623482027 0.347341680628551 no 2219 0.318278325951208 3370 408974
SGTC_2883 9059145 45.46 µM -0.472646762090369 0.34729861691324 no 2220 0.318232607277879 3177 16476510
SGTC_1616 st002734 56.1 µM -0.475953867647092 0.346187876854669 no 2221 0.317053622073792 3207 4026101
SGTC_2534 helenine 20.12 µM -0.477065115179404 0.34581494423684 no 2222 0.316657877358308 3247 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58
SGTC_3068 9116768 49.47 µM -0.479109538491685 0.345129230404207 no 2223 0.31593035217387 3327 41904888
SGTC_2001 4023502 57.655 µM -0.482424759932885 0.344018362957566 no 2224 0.314752117817201 3315 108941 YCR052W RSC6
SGTC_168 3970-0862 530.542 µM -0.483592884963077 0.343627266475926 no 2225 0.314337412633947 3307 3135186
SGTC_2820 7989630 71.43 µM -0.483880070751035 0.343531140261709 no 2226 0.314235492416504 3288 2984098
SGTC_3067 9117431 49.47 µM -0.48553893428083 0.342976087193777 no 2227 0.313647050776483 3255 17150885
SGTC_1291 0993-0025 5.79 µM -0.485923550086322 0.342847443687673 no 2228 0.313510685250623 3387 4353356
SGTC_3197 9113331 49.47 µM -0.486073739508779 0.342797214363864 no 2229 0.313457442511622 3427 16610459 YLR208W | YDL195W SEC13 | SEC31
SGTC_2838 9002687 71.43 µM -0.486585377271619 0.342626123182987 no 2230 0.313276094097838 3209 6457060
SGTC_1973 st070275 50.2 µM -0.489012175081986 0.34181504448727 no 2231 0.312416538636167 3318 17118334
SGTC_1027 k015-0025 8.67 µM -0.489031582445997 0.34180856113931 no 2232 0.312409668782196 3283 3598955
SGTC_336 4111-0029 111 µM -0.489896375185916 0.341519710338721 no 2233 0.312103614089276 3284 3131175
SGTC_985 1493-0307 8.71 µM -0.490206747469684 0.341416065017156 no 2234 0.31199380331071 3400 3278274
SGTC_1999 st074831 12.5 µM -0.491930188191667 0.340840759200128 no 2235 0.31138434823207 3253 17112523
SGTC_987 1497-1013 404 µM -0.492020423848875 0.340810647603149 no 2236 0.311352452689223 3355 1676435
SGTC_2185 6113692 200 µM -0.494770576745652 0.339893410158093 no 2237 0.310381037995183 3372 874150
SGTC_2077 5212015 200 µM -0.496402846714285 0.339349459112961 no 2238 0.30980510850955 3276 780900
SGTC_2954 9074818 52.69 µM -0.496666356340931 0.339261676339103 no 2239 0.309712175578597 3381 16648742
SGTC_212 3807-4682 38.772 µM -0.497267560186298 0.339061430392372 no 2240 0.309500192292868 3350 3125501 YBL034C STU1
SGTC_2239 6685329 187.64 µM -0.497355232872954 0.339032232612369 no 2241 0.309469284369701 3364 805680
SGTC_2532 xanthone 78.9 µM -0.49779509960847 0.338885757662035 no 2242 0.309314235129543 3339 7020 An insecticide.
SGTC_2428 5615643 7.78 µM -0.498253888011415 0.3387330077761 no 2243 0.309152552332957 3348 2253075
SGTC_229 benomyl 22.8748 µM -0.499531732778057 0.338307699564396 no 2244 0.308702418673684 3347 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C
SGTC_1590 st077108 57.8 µM -0.499918744592693 0.338178930132007 no 2245 0.308566146518611 3365 5489485
SGTC_152 4469-0003 551.229 µM -0.500282236711056 0.338058003583246 no 2246 0.30843817997824 3397 697280
SGTC_2864 9034755 47.6 µM -0.502208507845091 0.33741745087854 no 2247 0.307760429463685 3391 4930451
SGTC_1606 st000094 49.2 µM -0.504032702393866 0.336811276246005 no 2248 0.307119198302971 3412 1242210
SGTC_384 k007-0144 5.16 µM -0.504462088886642 0.336668653882885 no 2249 0.306968348271841 3320 6824886
SGTC_1809 st050081 57.6 µM -0.50478742674727 0.336560607309881 no 2250 0.306854073868389 3446 5036894
SGTC_601 0986-0029 62.9 µM -0.505432769054383 0.336346325354179 no 2251 0.306627453952886 3339 24747981
SGTC_2847 9005661 71.43 µM -0.506415103429678 0.336020249293745 no 2252 0.306282637009609 3326 2991449
SGTC_374 0880-0231 82.3 µM -0.506692523484053 0.335928184813626 no 2253 0.306185288650043 3329 6833587
SGTC_1966 st070145 16.1 µM -0.509312799356908 0.335059107605522 no 2254 0.305266493870723 3258 3748532
SGTC_1574 spiramycin 23.7 µM -0.509657763385051 0.3349447576585 no 2255 0.305145624064764 3310 6419898 An antibiotic and protein synthesis inhibitor.
SGTC_546 peri-Naphthalide 147 µM -0.510336946782068 0.334719664167383 no 2256 0.304907711319179 3294 223824 A penicillin ester.
SGTC_2164 5685496 200 µM -0.510580198305767 0.334639060711749 no 2257 0.304822522220762 3403 759046
SGTC_2352 9027995 87.8 µM -0.510949373609854 0.33451674590204 no 2258 0.30469325357821 3317 2997347
SGTC_638 3970-0837 4.09 µM -0.511158126107377 0.334447589995863 no 2259 0.304620168601719 3316 4118451 YLR208W SEC13
SGTC_1664 st014217 9.02 µM -0.51119248804035 0.334436207050729 no 2260 0.304608139116694 3425 3982782
SGTC_1511 0906-3109 28.5 µM -0.511273762161141 0.334409284291686 no 2261 0.304579687372646 3375 2882180
SGTC_3166 9102297 49.47 µM -0.512758436527641 0.333917623000004 no 2262 0.304060153556839 3339 25237072
SGTC_918 glabranin 770.725 nM -0.512850351148528 0.333887194127397 no 2263 0.304028002754525 3338 124049 Also referred to as licorice root.
SGTC_2182 6325192 200 µM -0.514088249482086 0.33347748712875 no 2264 0.303595146201435 3383 736248
SGTC_375 3970-0961 9.27 µM -0.514296146955674 0.333408698797545 no 2265 0.303522477578139 3316 2898222
SGTC_420 mitomycin C 81.9 mM -0.514394557547779 0.333376139025654 no 2266 0.30348808178249 3293 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_3144 9087057 49.47 µM -0.516047317500904 0.332829500613412 no 2267 0.30291068081414 3381 17249618
SGTC_2757 clomiphene 4.22 µM -0.518098158764449 0.332151693491208 no 2268 0.302194892415571 3499 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined.
SGTC_976 1348-1067 47.6 µM -0.518972189276699 0.331862991301146 no 2269 0.30189006756042 3350 5310671 YGL099W LSG1
SGTC_3248 9135562 49.47 µM -0.519230016334588 0.331777847156292 no 2270 0.301800174789192 3357 17650701
SGTC_2375 9072683 200 µM -0.522003254895234 0.330862570102365 no 2271 0.300834032168021 3461 16798029
SGTC_554 4483-2211 187 µM -0.522122368760592 0.330823280460932 no 2272 0.300792566468663 3365 747107
SGTC_423 5-fluorouracil 457 µM -0.522710305521847 0.330629377158216 no 2273 0.300587932792542 3235 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_3208 9114115 49.47 µM -0.523872232986173 0.330246303704193 no 2274 0.300183704393635 3345 650895
SGTC_2114 5491910 81.25 µM -0.525115411060353 0.329836639847969 no 2275 0.299751481730966 3423 2849228
SGTC_2201 6605497 169.863 µM -0.526581588180328 0.329353753442815 no 2276 0.299242090283284 3363 670741
SGTC_11 0438-0307 1.3 µM -0.527289108906719 0.329120832734194 no 2277 0.298996418127926 3422 4011476
SGTC_2997 9067075 71.4286 µM -0.527512113485617 0.329047431828855 no 2278 0.298919003320913 3376 27209819
SGTC_1244 0416-0015 52.5 µM -0.528313998967634 0.32878354948106 no 2279 0.298640708472577 3321 96201
SGTC_1585 2',4'-dihydroxychalcone 10.4 µM -0.528633916733947 0.328678295597486 no 2280 0.298529713702458 3438 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_1319 1306-0155 43.7 µM -0.528772727190165 0.328632630777077 no 2281 0.298481559556331 3375 3122360
SGTC_938 3126-1755 342 µM -0.530241128592694 0.328149723948466 no 2282 0.2979723792371 3441 1777771
SGTC_76 0433-0009 400.328 µM -0.531075200507976 0.327875554104261 no 2283 0.29768333433976 3395 2841569
SGTC_628 1636-0253 16 µM -0.533164794863543 0.327189085856054 no 2284 0.296959754618537 3382 4456143
SGTC_2934 9036370 36.88 µM -0.53518052684578 0.326527436124367 no 2285 0.296262515231628 3370 6462800
SGTC_266 formosanin C 406 nM -0.535190488157387 0.326524167746978 no 2286 0.296259071490376 3387 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1
SGTC_2323 6148992 148.28 µM -0.53569507536196 0.326358626512564 no 2287 0.296084653850702 3307 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42
SGTC_2282 7944268 200 µM -0.536652830238557 0.326044507462379 no 2288 0.29575372213371 3484 2970414
SGTC_1400 3771-8998 51.5 µM -0.536857563309832 0.32597737626404 no 2289 0.295683003051937 3354 670767
SGTC_889 0919-1524 82.7 µM -0.537108415752947 0.325895130387878 no 2290 0.295596363971448 3383 3905452
SGTC_2066 5222451 176 µM -0.537769699098509 0.325678358963224 no 2291 0.295368026769203 3379 2281147
SGTC_2281 7943571 200 µM -0.537796131340208 0.325669695589128 no 2292 0.29535890156045 3502 1244024
SGTC_1733 st037357 54.9 µM -0.538688642436597 0.325377223382734 no 2293 0.295050855919714 3314 1272339 YGL099W LSG1
SGTC_2411 st077133 39.94 µM -0.538883380634108 0.325313422760354 no 2294 0.294983662698866 3554 1403142 YNL221C POP1
SGTC_847 0342-0274 5.54 µM -0.539025203758464 0.325266961530352 no 2295 0.294934731936804 3426 18097
SGTC_3334 9142812 21.919 µM -0.53945836281527 0.325125075519304 no 2296 0.294785309773849 3420 45283678
SGTC_1496 4469-0713 57.4 µM -0.541779779563068 0.324365102404326 no 2297 0.293985111320774 3447 746691
SGTC_1579 chlormadinone acetate 49.4 µM -0.542150901895941 0.324243674033406 no 2298 0.293857277647175 3457 45114258 A steroidal progestin.
SGTC_1951 sophoraflavanone G 9.2 µM -0.542253291610285 0.324210176196104 no 2299 0.293822013874353 3352 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity.
SGTC_999 SEC7.066 22.7 µM -0.542986136855083 0.323970459966861 no 2300 0.293569673737287 3377 740511 YDR170C SEC7
SGTC_2574 2',4'-dihydroxychalcone 14.64 µM -0.543966224870736 0.323649983843469 no 2301 0.293232357581422 3396 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_2277 7947813 106.88 µM -0.543968603381184 0.3236492062602 no 2302 0.293231539189862 3505 1246798
SGTC_1689 st020265 53.493 µM -0.545516052117222 0.323143477233974 no 2303 0.292699321726327 3454 5758320 YPR016C TIF6
SGTC_1328 1441-0025 69.2 µM -0.546861861338217 0.322703912543087 no 2304 0.292236819676949 3395 4562601
SGTC_2335 9018011 154.17 µM -0.548353033610478 0.322217158946676 no 2305 0.291724759427318 3395 6458208
SGTC_1555 citronellol 128 µM -0.550232816295149 0.321603988036945 no 2306 0.291079848982981 3435 8842 A terpine precursor.
SGTC_770 0389-1121 67.2 µM -0.55080653476223 0.321416942065157 no 2307 0.290883152016898 3517 6753108
SGTC_2252 omeprazole 400 µM -0.551831674963199 0.321082834539143 no 2308 0.290531841771785 3354 4594 A proton pump inhibitor.
SGTC_2343 7990716 14.84 µM -0.552291857765233 0.320932901598505 no 2309 0.290374204102056 3378 6456862
SGTC_574 1315-0397 40 µM -0.552475954197846 0.320872929001785 no 2310 0.290311152265747 3444 6794277
SGTC_1165 k072-0275 30.3 µM -0.552773852249221 0.320775893460578 no 2311 0.290209137696291 3490 6153523 YGL055W OLE1
SGTC_1656 st012921 11 µM -0.553136252179093 0.320657863968235 no 2312 0.290085057239688 3410 6732821
SGTC_457 grayanotoxin iii 135 µM -0.553712675510525 0.320470166868975 no 2313 0.289887749531672 3436 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity.
SGTC_2499 avocadenofuran 51.48 µM -0.554618277008519 0.320175374288021 no 2314 0.289577892464606 3312 6857792 A insecticide and lysyl oxidase inhibitor.
SGTC_461 N-acetylfarnesylcysteine 136 µM -0.55512972132581 0.320008938392041 no 2315 0.289402967414051 3464 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ).
SGTC_834 0312-0008 75.7 µM -0.556130142678477 0.319683482714884 no 2316 0.289060945206196 3458 6385573 YIL048W NEO1
SGTC_1290 0986-0249 10.2 µM -0.55802765567873 0.319066567878518 no 2317 0.288412749754491 3404 53329
SGTC_41 0478-0632 82.643 µM -0.558911209691797 0.318779479711542 no 2318 0.288111159351286 3487 3750424
SGTC_728 3030-5151 22.5 µM -0.561355185264713 0.317985939347854 no 2319 0.287277714093867 3466 3125388
SGTC_650 1328-0195 38 µM -0.564205777922589 0.317061428426199 no 2320 0.286307048027705 3452 2780821
SGTC_611 3453-1652 23.7 µM -0.564913650222402 0.31683202620614 no 2321 0.286066249324725 3475 1560575
SGTC_1932 st074806 40.9 µM -0.565373903853161 0.316682908248836 no 2322 0.285909735330622 3578 17251235
SGTC_1767 st044992 70.3 µM -0.565452507840091 0.316657444254735 no 2323 0.28588300930475 3418 9600693
SGTC_2512 diallyl trisulfide 49.23 µM -0.566809083403372 0.3162181145597 no 2324 0.285421949293414 3472 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent
SGTC_1202 1988-0068 29.6 µM -0.567398524119753 0.316027303790029 no 2325 0.285221726193615 3363 2850480
SGTC_1709 st033179 39.1045 µM -0.568124615093897 0.315792324644801 no 2326 0.284975177338839 3426 573381
SGTC_584 0986-0246 15.4 µM -0.568497795984333 0.315671583981688 no 2327 0.284848500924964 3524 53315 YDR232W HEM1
SGTC_28 pentachloropyridine N-oxide 1.606 µM -0.569912566450135 0.315214021367807 no 2328 0.284368500627704 3475 140250 A respiratory chain inhibitor.
SGTC_1645 Cervolide 78 µM -0.571631566604595 0.314658446600184 no 2329 0.283785802592036 3436 23173 A fragrance.
SGTC_1851 st056236 18.9 µM -0.57180110526395 0.31460367500376 no 2330 0.28372836421547 3522 5393171
SGTC_3191 9110352 49.47 µM -0.571985033099237 0.314544259416559 no 2331 0.283666057195116 3468 17122424
SGTC_2120 5538279 151.968 µM -0.572907613813366 0.314246303740675 no 2332 0.283353624549034 3490 2058197
SGTC_1953 st076800 12.1 µM -0.573792400824849 0.313960667536994 no 2333 0.283054145853822 3404 297591
SGTC_2305 7443522 69.23 µM -0.574346418798698 0.313781870375841 no 2334 0.282866701739399 3450 5415886
SGTC_3057 9095946 49.47 µM -0.575737638794514 0.313333077433117 no 2335 0.28239626519505 3466 24540043
SGTC_1236 0330-0013 258 µM -0.578315535164867 0.312502205789582 no 2336 0.28152555392793 3416 4617066
SGTC_277 nystatin 15.5 µM -0.579697571847828 0.312057158759653 no 2337 0.281059290548323 3406 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_378 3970-0959 8.33 µM -0.581478399352673 0.311484096385076 no 2338 0.280459036127343 3488 6615653
SGTC_2063 5246145 200 µM -0.582017719885365 0.311310635411254 no 2339 0.280277372617139 3502 711240
SGTC_572 0960-0087 17.7 µM -0.582635271618895 0.311112064478528 no 2340 0.280069427907264 3436 6796365
SGTC_100 0086-0128 49.5915 µM -0.583300369585567 0.310898266750831 no 2341 0.279845556891661 3464 93297
SGTC_1701 st028638 40.4 µM -0.583843980357405 0.310723568837224 no 2342 0.279662642778661 3505 3490878
SGTC_2473 5854593 8.94 µM -0.584685291520049 0.310453284316991 no 2343 0.279379672902374 3444 2872951
SGTC_1171 0368-0077 21.4 µM -0.586834781620117 0.309763191505706 no 2344 0.278657337295506 3456 3239779
SGTC_979 1426-2828 121 µM -0.588818180158084 0.309127016449562 no 2345 0.277991624420268 3542 747872
SGTC_332 4112-0506 40.9 µM -0.589573936854487 0.308884757880517 no 2346 0.277738164691938 3481 2790355
SGTC_1822 st052468 42 µM -0.590345209349406 0.308637611400401 no 2347 0.277479617808876 3432 2873678
SGTC_3287 9117173 37.0625 µM -0.590369125615375 0.308629949059286 no 2348 0.277471602450597 3444 2789709
SGTC_3020 9089140 49.47 µM -0.591157830035749 0.308377309059941 no 2349 0.277207337465393 3521 17217859
SGTC_1714 st033236 13.627 µM -0.592020308990495 0.308101141241804 no 2350 0.276918494438394 3579 2916566
SGTC_739 1486-1183 203 µM -0.595182303442354 0.307089593032972 no 2351 0.275860809048909 3518 4346692
SGTC_1621 st003705 32.4 µM -0.595205752882612 0.307082096831597 no 2352 0.275852972644355 3538 24207032
SGTC_947 3447-0010 211 µM -0.596569026823617 0.306646430833883 no 2353 0.275397577759427 3531 748350
SGTC_3145 9085516 49.47 µM -0.597265606159652 0.306423928015543 no 2354 0.275165031770832 3494 25236195
SGTC_1568 digitonin 820 nM -0.597991543369059 0.306192123567448 no 2355 0.274922787883234 3553 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1
SGTC_130 0136-0219 337.655 µM -0.598025004224462 0.306181440800481 no 2356 0.274911624592533 3492 234244
SGTC_3086 9117350 49.47 µM -0.599347340327357 0.305759401651054 no 2357 0.274470642582998 3458 2679265
SGTC_1313 1220-0047 237 µM -0.600741715913064 0.305314649541371 no 2358 0.274006014770286 3509 3528706
SGTC_660 4031-1742 102 µM -0.603057916935177 0.304576505680342 no 2359 0.27323508038868 3467 6738706
SGTC_2955 9076254 12.21 µM -0.603447487697692 0.304452432453411 no 2360 0.273105519613764 3458 16459619
SGTC_2796 7949634 45.45 µM -0.605971371481872 0.303649153828783 no 2361 0.272266881964073 3517 2971588
SGTC_1586 deoxycorticosterone acetate 53.7 µM -0.605980351010076 0.303646297596393 no 2362 0.27226390052696 3513 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE.
SGTC_1104 tacrolimus 29.8 µM -0.606077837544736 0.303615289590181 no 2363 0.272231533503909 3549 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41
SGTC_2658 polymyxin b sulfate 77.05 µM -0.606558898772865 0.303462296860044 no 2364 0.27207184181143 3504 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides. YIL048W NEO1
SGTC_273 hydroxyurea 18.1 mM -0.608800031428494 0.302750000000887 no 2365 0.271328496391588 3565 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12
SGTC_2879 9041815 71.43 µM -0.609819878598411 0.30242611115065 no 2366 0.270990565912706 3492 4942971
SGTC_1262 0737-0114 49.6 µM -0.611413198747762 0.301920406773871 no 2367 0.270463033460555 3579 765919
SGTC_1572 epiandrosterone 68.9 µM -0.611666271754099 0.301840118830498 no 2368 0.270379290756518 3516 441302 A steroid.
SGTC_1753 st043925 64 µM -0.612408345764551 0.301604749628345 no 2369 0.270133810726077 3534 670181
SGTC_3304 9125678 46.087 µM -0.613277500743417 0.301329178222347 no 2370 0.269846433803317 3522 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2
SGTC_522 1273-0010 11.6 µM -0.61366680432782 0.301205783687223 no 2371 0.269717764331305 3602 5705015
SGTC_3225 9130819 49.47 µM -0.614164428906436 0.301048088639998 no 2372 0.269553338235648 3543 4547121
SGTC_294 k038-0071 157 µM -0.614906189807222 0.300813096965684 no 2373 0.26930833740905 3534 24152826
SGTC_2126 5251174 33.877 µM -0.615191189567285 0.300722830352083 no 2374 0.269214232768758 3588 790722
SGTC_2900 5328528 85.29 µM -0.616015704180857 0.300461754635939 no 2375 0.268942077562906 3555 795359
SGTC_2810 7959871 45.46 µM -0.616262450671613 0.300383644314099 no 2376 0.268860658515748 3507 2974535
SGTC_542 3381-0244 89.3 µM -0.617603669261127 0.299959227358134 no 2377 0.268418312642387 3576 1112843
SGTC_1431 4049-0260 9.09 µM -0.617700223112638 0.299928684205473 no 2378 0.268386482446269 3531 3854841
SGTC_1620 st003704 16.5 µM -0.618162021963036 0.299782621539629 no 2379 0.268234270880563 3538 2834414
SGTC_3130 9127414 49.47 µM -0.619944245880313 0.299219223026421 no 2380 0.26764724714814 3557 1494646
SGTC_1928 4'-methoxychalcone 40.3 µM -0.620470960654453 0.299052809418594 no 2381 0.267473883413343 3610 641818
SGTC_1692 fluoroquinolonic acid 71 µM -0.620490285909433 0.299046704474172 no 2382 0.267467523745477 3565 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2
SGTC_523 1934-0222 13.7 µM -0.621919491433934 0.298595368255277 no 2383 0.266997403901556 3550 1361595
SGTC_932 2857-0803 154 µM -0.622145831267578 0.298523919651077 no 2384 0.266922990451328 3625 674898
SGTC_446 go6976 132 µM -0.623418054075537 0.298122462386109 no 2385 0.266504918460939 3528 3501 A protein kinase C inhibitor.
SGTC_473 2-arachidonoylglycerol 10 µM -0.623655924152889 0.29804742840829 no 2386 0.266426787460706 3471 5282280 An endocannabinoid.
SGTC_912 3474-0017 2.18 µM -0.625531099042013 0.297456222914025 no 2387 0.265811272003642 3584 3360550
SGTC_1751 st044839 27.194 µM -0.625585604148876 0.297439046545698 no 2388 0.265793391798512 3574 5291326
SGTC_2312 7706453 155.7 µM -0.625759775807938 0.297384162311421 no 2389 0.26573625949641 3542 976098
SGTC_1783 st039459 87.517 µM -0.626976536801349 0.29700087086096 no 2390 0.265337307707645 3604 729761
SGTC_1081 sertraline 6 µM -0.62743162098294 0.296857573039431 no 2391 0.265188172787643 3568 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1
SGTC_2948 9070189 9.45 µM -0.628144908101121 0.29663303544502 no 2392 0.264954508263061 3505 6473636 YDL196W YDL196W
SGTC_2544 sphondin 68.51 µM -0.629082318746369 0.296338063746137 no 2393 0.264647582670493 3584 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31
SGTC_3094 9117742 49.47 µM -0.630449861303543 0.295907985340719 no 2394 0.264200148505332 3523 17149698
SGTC_1170 0310-0127 64.8 µM -0.632107065273606 0.295387195801035 no 2395 0.263658459386869 3532 774975
SGTC_1787 fluconazole 80 µM -0.632560120347378 0.29524489307108 no 2396 0.263510468267291 3516 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C
SGTC_2051 5263410 176 µM -0.635434866117941 0.294342683541649 no 2397 0.262572417217281 3633 227584
SGTC_1198 1612-1005 86.7 µM -0.636141810312587 0.294121011528299 no 2398 0.262341998127796 3645 6998509
SGTC_1391 3442-0225 151 µM -0.636385405772268 0.294044646718995 no 2399 0.262262625412502 3535 5227075
SGTC_444 curcumin 90.4 µM -0.636948505611756 0.293868155481965 no 2400 0.262079193050534 3557 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties.
SGTC_2271 7849410 118.62 µM -0.637910550760981 0.293566737051624 no 2401 0.261765954630968 3574 972430
SGTC_2441 5730946 39.09 µM -0.638603075605981 0.293349850699555 no 2402 0.261540589996105 3596 1774275
SGTC_1934 st074720 32.6 µM -0.638980895926254 0.293231555469915 no 2403 0.261417679968829 3573 17250992
SGTC_2975 9084847 53.72 µM -0.639390097005157 0.293103459902365 no 2404 0.261284594827482 3548 27211724
SGTC_2698 st077697 67.5 µM -0.640390644198292 0.29279035977426 no 2405 0.260959331880961 3518 3154499
SGTC_1774 st048371 48.465 µM -0.640536812738768 0.292744632417656 no 2406 0.26091183210876 3541 4242727
SGTC_98 0074-0023 107.663 µM -0.640989553694035 0.292603018015749 no 2407 0.260764735017646 3552 3563821
SGTC_2498 4'-Methoxychalcone 54.63 µM -0.641045826845827 0.292585418367009 no 2408 0.260746454659265 3501 641818 YHR062C RPP1
SGTC_557 1315-0110 16.2 µM -0.641210278178249 0.292533988387584 no 2409 0.26069303635033 3565 6833801
SGTC_1892 st058411 7.36 µM -0.642985098103183 0.291979204457044 no 2410 0.260116884695819 3561 3934738
SGTC_2964 9083345 53.42 µM -0.644542181006544 0.291492885886142 no 2411 0.259611957116437 3532 17741579
SGTC_1900 st060200 72.8 µM -0.645776358197473 0.291107687997281 no 2412 0.259212100520356 3597 688945
SGTC_1618 st003135 44.5 µM -0.645891018879671 0.291071913431497 no 2413 0.259174968188561 3539 1270615
SGTC_2990 9074105 71.4286 µM -0.646743082670512 0.290806130664022 no 2414 0.258899117432647 3565 6502001
SGTC_2420 aureobasidin a 50 nM -0.647055281827886 0.290708775338103 no 2415 0.258798082785657 3651 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1
SGTC_313 3474-0040 5.03 µM -0.647995282862866 0.290415740080695 no 2416 0.258494000626254 3574 1043375 YIL048W NEO1
SGTC_1713 st033146 12.748 µM -0.649150317595413 0.290055859840336 no 2417 0.258120610499247 3615 674619
SGTC_2080 5212524 12.4 µM -0.649771669122858 0.289862348592554 no 2418 0.257919860840072 3582 260183
SGTC_898 1000-0849 28.3 µM -0.652395450608751 0.289045877005486 no 2419 0.25707304921112 3570 6751807
SGTC_2539 epi(13)torulosol 80 µM -0.652799366209176 0.288920282192414 no 2420 0.256942816137332 3569 6708597
SGTC_2229 7354935 190 µM -0.653345597779392 0.288750476053316 no 2421 0.25676675124502 3552 318112
SGTC_2198 6589944 200 µM -0.655024961269027 0.28822870952966 no 2422 0.256225841554108 3565 5290268
SGTC_3271 9137798 49.47 µM -0.655320316005596 0.288136990877529 no 2423 0.256130771597849 3547 6498326
SGTC_606 k015-0008 38.6 µM -0.655554322195588 0.288064333014169 no 2424 0.256055461818831 3648 1970475
SGTC_805 3852-0218 479 µM -0.656964191935848 0.287626757931399 no 2425 0.255601970598435 3571 6615355
SGTC_1745 st081495 74 µM -0.657139378973841 0.287572407850951 no 2426 0.255545650180452 3571 13842402 YBL026W LSM2
SGTC_2075 5212009 200 µM -0.658221731553093 0.287236726160332 no 2427 0.255197831313201 3544 780898
SGTC_2108 5365811 200 µM -0.659216934435877 0.286928236893712 no 2428 0.254878236980176 3625 780283
SGTC_1473 k844-0725 134 µM -0.659492454557087 0.286842859949155 no 2429 0.25478979490503 3674 54682906
SGTC_3089 9117425 49.47 µM -0.660559236115264 0.286512404047319 no 2430 0.254447509164488 3554 9401657
SGTC_2003 4023581 200 µM -0.661094316374706 0.286346720794329 no 2431 0.254275914996693 3629 16641307
SGTC_2841 9004761 38.96 µM -0.661977572563984 0.286073327240978 no 2432 0.253992797543864 3516 2991039
SGTC_158 k038-0087 26.446 µM -0.663497800526925 0.285603062998039 no 2433 0.253505893839886 3578 X158
SGTC_2708 st078559 56 µM -0.663979214027298 0.28545422025353 no 2434 0.253351807417812 3548 17250902
SGTC_2907 7721985 69.9 µM -0.664197469874613 0.285386752389688 no 2435 0.253281966308927 3581 3267881
SGTC_1646 st011709 75.6 µM -0.66445815109146 0.285306179829254 no 2436 0.253198562497011 3597 5757843
SGTC_1188 1403-0014 4.57 µM -0.66513092999956 0.285098284289794 no 2437 0.252983376592979 3646 9614867
SGTC_644 1498-1197 63.3 µM -0.665507006989288 0.284982104142006 no 2438 0.252863131670795 3646 6741615
SGTC_1151 3909-8316 15.3 µM -0.666902851560197 0.284551088297831 no 2439 0.252417094694095 3642 800431
SGTC_917 harmaline 728.087 nM -0.668907878360284 0.283932511456685 no 2440 0.25177712213948 3603 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7
SGTC_2405 ticlatone 3.52 µM -0.670417208749342 0.283467288359426 no 2441 0.251295933760453 3537 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W
SGTC_490 phenamil 164 µM -0.670822280750699 0.283342494642068 no 2442 0.251166875894838 3560 4755 Irreversibly blocks amiloride-sensitive Na+ channels.
SGTC_2013 4024628 200 µM -0.670862107628456 0.283330226285126 no 2443 0.251154188755284 3642 5230760
SGTC_1237 0330-0133 46.1 µM -0.671338997037083 0.283183344037227 no 2444 0.251002298523266 3585 X1237 YHR072W ERG7
SGTC_1047 2043-3044 82 µM -0.672879928323923 0.282708986088911 no 2445 0.250511841286636 3624 669592
SGTC_3270 9137563 49.47 µM -0.673896267760051 0.282396326804784 no 2446 0.250188632555479 3597 17015724
SGTC_2165 5727197 32.143 µM -0.675387857955049 0.281937766222028 no 2447 0.249714688857218 3764 1361712
SGTC_1138 3761-0006 1.03 µM -0.676183534984148 0.28169329749514 no 2448 0.249462062471785 3619 12061087
SGTC_3313 9133968 57.047 µM -0.676861328454002 0.281485128683823 no 2449 0.24924697113054 3625 1494643
SGTC_2041 5107442 45.335 µM -0.677116418804129 0.281406802725436 no 2450 0.249166046171437 3649 793005
SGTC_737 1950-0117 57.9 µM -0.678819857866111 0.280884028447593 no 2451 0.248626004952839 3610 5393513
SGTC_1990 st072050 59.8 µM -0.679169330056618 0.280776835789379 no 2452 0.248515288924072 3649 17233948
SGTC_2857 9024691 58.44 µM -0.679896515975247 0.28055385144998 no 2453 0.248284993914565 3663 16478292
SGTC_1278 0874-0585 172 µM -0.682010190766525 0.279906201058783 no 2454 0.247616253509126 3660 766306
SGTC_369 0957-0393 4.5 µM -0.682755238319954 0.279678084236765 no 2455 0.247380759278128 3631 6997992
SGTC_2353 9059630 146.67 µM -0.68300218091276 0.279602495875775 no 2456 0.247302732218 3664 4779114
SGTC_207 4185-0010 4.486 µM -0.683707957036577 0.279386514686414 no 2457 0.247079798953863 3701 3761753
SGTC_2119 5528445 120.635 µM -0.683734904267011 0.279378269917505 no 2458 0.247071289272539 3657 791935
SGTC_540 1187-0821 17.3 µM -0.68730199645058 0.278287927780063 no 2459 0.245946220502888 3647 847520
SGTC_3331 9141060 1.957 µM -0.687438693325597 0.278246185371833 no 2460 0.245903160767179 3648 4906567 YPR165W RHO1
SGTC_1367 1812-0510 76.9 µM -0.687510963761734 0.278224117761254 no 2461 0.245880397098481 3660 1142582 YDR527W RBA50
SGTC_2827 7993847 71.43 µM -0.688046773314466 0.278060536175771 no 2462 0.245711663630008 3620 2985692
SGTC_244 nsc-207895 1.295 µM -0.689594561966444 0.277588263100195 no 2463 0.245224594056957 3538 42640
SGTC_1142 3253-1408 9.78 µM -0.691858065407274 0.276898312120908 no 2464 0.244513233778676 3645 256655
SGTC_2952 9073731 13.78 µM -0.695007859364724 0.275939605560533 no 2465 0.243525188095341 3683 16457353
SGTC_1072 oxiconazole 14.9 nM -0.695951209835105 0.275652794448152 no 2466 0.24322969264968 3682 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_2872 9044037 25.97 µM -0.698248767627249 0.274954871313977 no 2467 0.242510816445689 3668 6465195
SGTC_3242 9133940 49.47 µM -0.698463452846657 0.274889701451246 no 2468 0.242443703047635 3704 17248444
SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM -0.699078701816265 0.27470297860249 no 2469 0.242251423947319 3619 1241132 A phosphatase inhibitor.
SGTC_1145 3546-0597 10.2 µM -0.700748956975329 0.274196385900131 no 2470 0.241729848776873 3647 875334
SGTC_170 4197-0004 226 µM -0.700802292334756 0.274180216753446 no 2471 0.24171320364583 3676 218692
SGTC_669 0108-0021 26.2 µM -0.70098779827668 0.274123982443044 no 2472 0.241655314989489 3743 17201
SGTC_1703 st026983 48.3 µM -0.702678019666173 0.273611870997261 no 2473 0.241128214354064 3687 1104023
SGTC_1833 st055984 71 µM -0.702701061939484 0.273604892810088 no 2474 0.241121032872768 3708 676288
SGTC_3352 9151559 45.5865 µM -0.704767502224873 0.272979444516353 no 2475 0.240477467800625 3669 17159339
SGTC_2057 5236571 38.335 µM -0.70560159181198 0.27272719206003 no 2476 0.240217967037143 3672 54684039 YBR257W POP4
SGTC_3090 9117696 49.47 µM -0.706344471946942 0.272502621364787 no 2477 0.239986971774947 3652 7923821
SGTC_3009 9080819 71.4286 µM -0.707049614050317 0.272289543751356 no 2478 0.239767823085057 3703 17027216
SGTC_1143 3454-2408 5.08 µM -0.707295406133471 0.272215290538204 no 2479 0.239691459879756 3640 X1143
SGTC_3158 9100007 49.47 µM -0.707514498824868 0.272149111632938 no 2480 0.239623402887807 3696 19297233
SGTC_1015 4130-4525 82 µM -0.707626222541697 0.272115367565147 no 2481 0.239588702093806 3698 1363237
SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM -0.708487472271435 0.271855312965553 no 2482 0.239321294594291 3688 688798
SGTC_197 4544-0043 41.561 µM -0.708494520474965 0.271853185268724 no 2483 0.239319106886146 3686 896523
SGTC_2728 chlorpromazine 9.18 µM -0.70926584429244 0.271620389739401 no 2484 0.239079759934428 3704 2726 A thorazine and dopamine antagonist.
SGTC_3074 9116018 49.47 µM -0.7100041488201 0.271397652873809 no 2485 0.23885078170754 3734 17027303
SGTC_1875 nocodazole 6 µM -0.711961648053955 0.270807541699712 no 2486 0.238244262690434 3670 4122 A microtubule depolymerizer. YJL014W CCT3
SGTC_299 1273-0059 1.44 µM -0.712767109870905 0.27056491188611 no 2487 0.237994940562252 3648 2848077
SGTC_977 1348-1378 135 µM -0.713023616867543 0.270487666912174 no 2488 0.237915571590534 3693 X977
SGTC_727 3032-0951 202 µM -0.713176104724985 0.270441751670084 no 2489 0.237868395333828 3681 3652836
SGTC_1914 st062367 72.6 µM -0.713491150907182 0.270346901230475 no 2490 0.23777094349739 3700 978205
SGTC_2061 5245884 80.95 µM -0.713644171703299 0.270300837509986 no 2491 0.237723618156645 3681 573863
SGTC_2106 5357045 167.29 µM -0.713833079800613 0.270243976078423 no 2492 0.237665200937641 3728 668842
SGTC_2665 lovastatin 100 µM -0.714641315767748 0.270000764208116 no 2493 0.237415354090043 3716 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1
SGTC_2657 nystatin 74.44 µM -0.715111583413555 0.269859303144377 no 2494 0.23727004846473 3710 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_3004 9076122 71.4286 µM -0.715145538096656 0.269849090683178 no 2495 0.237259558869628 3684 44782551
SGTC_54 0159-0055 9 µM -0.718693464155252 0.268783057796578 no 2496 0.236164905615464 3729 3319099
SGTC_2479 5617353 43.85 µM -0.720381982331459 0.268276458623259 no 2497 0.235644920209154 3729 2731746
SGTC_298 1391-0729 10 µM -0.720893279416054 0.268123151062577 no 2498 0.235487589036426 3679 3237558
SGTC_1129 3453-1384 223 µM -0.723268100564521 0.267411662073165 no 2499 0.23475759344088 3814 1084452
SGTC_659 k018-0002 107 µM -0.725886415726425 0.266628328344172 no 2500 0.233954202415128 3690 6797879 YHR007C ERG11
SGTC_3230 9131665 49.47 µM -0.727558369216246 0.266128729773746 no 2501 0.233441986282431 3647 15943720
SGTC_1375 2910-0797 186 µM -0.729193532229056 0.265640583524245 no 2502 0.232941643498153 3741 742508
SGTC_3138 9097216 49.47 µM -0.729286566373558 0.265612823640289 no 2503 0.232913193943328 3727 25237486
SGTC_1796 st049173 110.4 µM -0.730185118020039 0.265344786109247 no 2504 0.232638518982842 3667 94134
SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM -0.730696682531084 0.265192248010962 no 2505 0.232482221175931 3782 6728940
SGTC_2286 7945697 125 µM -0.731130786389923 0.265062842032687 no 2506 0.232349635661249 3736 1245733
SGTC_52 0329-0193 875 nM -0.731198548900179 0.265042644982855 no 2507 0.232328943195159 3791 3739292
SGTC_261 5-fluorouridine 15.376 µM -0.733189421072221 0.264449601920351 no 2508 0.231721453341384 3760 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_3035 9091303 49.47 µM -0.733508028293762 0.264354757595596 no 2509 0.231624316535719 3768 25237002
SGTC_516 3992-2719 87.3 µM -0.734395890238491 0.264090546550365 no 2510 0.231353745418046 3700 5350887 YDR037W KRS1
SGTC_1316 1272-0050 65.9 µM -0.736341955702781 0.2635119049944 no 2511 0.230761309583802 3728 7340392
SGTC_317 4495-0002 170 µM -0.73815933568837 0.262972111572001 no 2512 0.230208815170745 3754 15991618
SGTC_409 arachidonic acid 100 µM -0.738449788774776 0.262885894376474 no 2513 0.230120584316557 3742 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes.
SGTC_2247 cerulenin 830 nM -0.740179825787186 0.262372655141772 no 2514 0.229595443578142 3761 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12
SGTC_1433 4060-0023 7.6 µM -0.741008127293999 0.262127109898667 no 2515 0.229344256256636 3750 3840627
SGTC_3179 9107801 49.47 µM -0.741384998711956 0.262015427515729 no 2516 0.229230018786352 3741 4818259
SGTC_1112 tnp00069 1.16933 µM -0.742477980207376 0.261691670499634 no 2517 0.228898894154811 3798 145826
SGTC_2671 danthron 100 µM -0.74264075057248 0.261643473117316 no 2518 0.228849604970825 3724 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin.
SGTC_224 benfluorex 43.875 µM -0.743123514650226 0.261500550276363 no 2519 0.228703452176139 3720 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis.
SGTC_1808 st050063 61.5 µM -0.743360544594976 0.261430391972482 no 2520 0.228631712526326 3723 4011993
SGTC_426 0988-0037 14.6 µM -0.743971651564341 0.261249555504654 no 2521 0.228446812765736 3729 5383008
SGTC_723 4182-0001 115 µM -0.746871702972276 0.260392260279769 no 2522 0.227570504162844 3731 744821 YLR208W SEC13
SGTC_1426 4048-4480 71.7 µM -0.74712207872611 0.260318313762462 no 2523 0.227494936980499 3729 14224343
SGTC_1611 st001856 99.4 µM -0.747783132741075 0.260123128642638 no 2524 0.227295488828384 3740 647478
SGTC_3256 9138902 49.47 µM -0.748268113949272 0.259979979387605 no 2525 0.227149226695862 3771 17228773
SGTC_2408 sulbentine 18.36 µM -0.752657359013929 0.25868628003595 no 2526 0.225827919955169 3770 67686 An antifungal agent of unknown mechanism. YDL205C HEM3
SGTC_3064 1327-0027 10 µM -0.753263246704819 0.258507960988702 no 2527 0.225645869933863 3646 16000455 YPR107C YTH1
SGTC_3183 9108214 49.47 µM -0.753674355830724 0.258387003562747 no 2528 0.225522391991111 3694 4974831
SGTC_83 0170-0301 39.027 µM -0.753991856961767 0.258293607758219 no 2529 0.225427055688351 3705 3089716
SGTC_1023 4482-3888 16 µM -0.754560084845507 0.25812650211673 no 2530 0.225256490444931 3742 3303168
SGTC_569 4130-2812 160 µM -0.754872426886739 0.258034671798417 no 2531 0.225162765720265 3634 743552
SGTC_1258 0671-0043 57.1 µM -0.757811075986045 0.25717152277887 no 2532 0.22428204536774 3788 4298767
SGTC_2991 9074669 71.4286 µM -0.758232178724615 0.257047958282662 no 2533 0.224156000251482 3730 17333109
SGTC_1240 0356-0016 42.1 µM -0.76035983804604 0.256424110089406 no 2534 0.223519761481698 3770 4305613
SGTC_928 2764-0428 58.7 µM -0.760603972867152 0.256352578128339 no 2535 0.223446823047386 3817 662578
SGTC_2206 7254556 146.969 µM -0.760759087072084 0.256307134778506 no 2536 0.223400487708771 3779 4398905
SGTC_1729 st035615 45.989 µM -0.760864602113551 0.2562762247487 no 2537 0.223368971636358 3848 17385451
SGTC_1763 st044482 94.5 µM -0.760985926423035 0.256240685885833 no 2538 0.223332736653066 3800 88505
SGTC_1826 st055655 41.6 µM -0.761563499300099 0.256071535875477 no 2539 0.223160283349611 3813 676168
SGTC_2556 citropten 84.59 µM -0.76162166179556 0.256054505432239 no 2540 0.223142921233866 3807 2775 A potential DNA crosslinker.
SGTC_2157 5649910 96.377 µM -0.762599074306758 0.255768399652966 no 2541 0.222851268411962 3743 2858091
SGTC_1540 guanosine 70.6 µM -0.76303220522964 0.255641668022775 no 2542 0.222722094757464 3689 6802 Guanosine is a purine nucleoside
SGTC_2928 9011484 9.79 µM -0.763211807013189 0.255589127188436 no 2543 0.222668544213515 3792 2994751
SGTC_784 4579-0127 173 µM -0.763345118038962 0.25555013193281 no 2544 0.222628800590595 3890 1948547
SGTC_2096 5468907 200 µM -0.764780988368951 0.255130317774766 no 2545 0.222200985229802 3816 759785
SGTC_368 fentichlor 4.58 µM -0.764910938781929 0.25509234118775 no 2546 0.222162289868434 3797 7329 A pesticide.
SGTC_3041 9091929 49.47 µM -0.765356532605129 0.254962143721393 no 2547 0.222029634510222 3806 25236887
SGTC_748 act1.228 77.9 µM -0.765533294283092 0.254910505596029 no 2548 0.22197702426475 3724 4421505 YNR035C ARC35
SGTC_2015 5119600 184 µM -0.765687958790508 0.254865327299212 no 2549 0.221930996722889 3783 2828786
SGTC_2970 9090938 41.86 µM -0.765759528257475 0.254844422908825 no 2550 0.221909699778957 3779 17217104
SGTC_438 sphingosine 6.67 µM -0.766279254323443 0.254692645483237 no 2551 0.221755079780366 3745 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes.
SGTC_1850 st056238 17 µM -0.766688304201236 0.254573222509935 no 2552 0.221633429561158 3783 5393177
SGTC_1978 st071761 42 µM -0.766760367415259 0.254552186542251 no 2553 0.221612002127032 3798 5147680
SGTC_1248 0469-0687 58.6 µM -0.769926110600731 0.25362897410112 no 2554 0.220671862174345 3790 4017482
SGTC_2299 7976368 114.88 µM -0.771016412710952 0.253311421497769 no 2555 0.220348601652821 3832 2979718
SGTC_1266 0828-0227 32.9 µM -0.771055008637822 0.253300184190999 no 2556 0.220337163435073 3822 3913820
SGTC_657 3534-0529 86.7 µM -0.772220683839103 0.252960918281402 no 2557 0.219991866499027 3803 1049549
SGTC_1378 2093-0007 380 nM -0.772734715195605 0.252811387165957 no 2558 0.21983969855091 3854 3618014
SGTC_405 ebelactone b 50 µM -0.774117918125399 0.252409246266297 no 2559 0.21943053115486 3764 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).
SGTC_3033 9090887 49.47 µM -0.774736733805189 0.252229446166303 no 2560 0.219247620085268 3831 19325384
SGTC_2383 9036125 200 µM -0.775981200749542 0.251868064438785 no 2561 0.218880042932156 3718 79580
SGTC_2409 alverine citrate 63.97 µM -0.77654048563213 0.251705742326667 no 2562 0.218714962968359 3976 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_2741 miltefosine 3.04 µM -0.776950750405916 0.251586705686329 no 2563 0.218593913737743 3755 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis.
SGTC_2947 9072639 7.68 µM -0.778800831979478 0.251050281763021 no 2564 0.218048523785163 3832 16488146
SGTC_1884 5633444 25 µM -0.778880590406684 0.251027169732477 no 2565 0.218025029259433 3837 5724239
SGTC_2898 9056270 58.44 µM -0.78067781899405 0.250506675730253 no 2566 0.217496004786359 3753 19154699
SGTC_1882 5615643 20 µM -0.781762818224375 0.250192726979808 no 2567 0.217176988099547 3725 2253075
SGTC_468 gf-109203x 121 µM -0.785623029066826 0.249077453957823 no 2568 0.216044184374464 3757 2396 A protein kinase C inhibitor.
SGTC_1886 st057356 49.9 µM -0.785636727111802 0.249073501101128 no 2569 0.216040170698846 3792 24207747
SGTC_2426 5582046 32.21 µM -0.786975192961026 0.248687419854944 no 2570 0.21564819405526 3795 2251934
SGTC_2702 st077768 96.8 µM -0.787110408522741 0.24864843458118 no 2571 0.215608618424664 3782 6484119
SGTC_3268 9137683 49.47 µM -0.788430260291941 0.248268066692853 no 2572 0.215222538231351 3836 1953228
SGTC_1854 st056233 32.9 µM -0.788773097561773 0.248169315254696 no 2573 0.215122317901224 3729 5393174
SGTC_1098 clofazimine 15.1 µM -0.789391815497092 0.247991151705943 no 2574 0.214941518996498 3891 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2
SGTC_2328 6201408 200 µM -0.789576693296066 0.247937928279186 no 2575 0.214887511987574 3823 2890418
SGTC_652 0437-0092 114 µM -0.78960430512498 0.24792997978875 no 2576 0.214879446621078 3774 3091274
SGTC_487 nimodipine 119 µM -0.791393393839064 0.247415253033353 no 2577 0.214357231886522 3687 4497 L-type voltage-gated calcium channels inhibitor
SGTC_1804 st050076 49.1 µM -0.793052338273861 0.246938480011117 no 2578 0.213873664979569 3853 3895976
SGTC_712 r015-0009 80.6 µM -0.795683385079524 0.246183338595371 no 2579 0.213108043204565 3856 6813872 YLR060W FRS1
SGTC_190 3970-0790 3.722 µM -0.796352645759443 0.245991450651162 no 2580 0.212913546978455 3750 2832352
SGTC_236 1509-0011 5.31 µM -0.798734821571661 0.245309093688199 no 2581 0.212222095532543 3892 3107280
SGTC_1470 k295-0292 231 µM -0.79954467895996 0.24507734787945 no 2582 0.211987325264071 3886 5045612
SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM -0.799830333827385 0.244995634036631 no 2583 0.211904552776003 3861 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W
SGTC_3018 9082602 49.47 µM -0.80013886392849 0.244907393019724 no 2584 0.211815173110847 3826 17332089
SGTC_919 tnp00227 403.569 nM -0.800294313923489 0.244862940091974 no 2585 0.211770148363657 3828 1269246 A methoxyflavone. YNL221C POP1
SGTC_626 0214-0009 33 µM -0.801909393159221 0.24440134442954 no 2586 0.21130268609589 3892 3437874
SGTC_3220 9131269 49.47 µM -0.802270047779415 0.244298332077889 no 2587 0.211198382245833 3873 17722206
SGTC_1329 1447-1697 50.6 µM -0.803039338993935 0.244078680697097 no 2588 0.21097599865667 3851 2840515
SGTC_2457 5731572 11.68 µM -0.803961809551232 0.243815433385582 no 2589 0.210709515689901 3913 2865357
SGTC_2102 5377816 72.7585 µM -0.804507289484105 0.243659840788433 no 2590 0.210552030586057 3864 1379702
SGTC_2673 kobusone 100 µM -0.804685431172131 0.243609039301544 no 2591 0.210500614398875 3872 6710676 An epoxy ketone and protein crosslinker.
SGTC_2245 6637752 200 µM -0.804902702050237 0.243547086906224 no 2592 0.210437914515816 3904 681890
SGTC_1941 st076221 61.8 µM -0.804957170386876 0.243531557194748 no 2593 0.210422197798872 3791 2828568
SGTC_2697 mebhydrolin 72.4 µM -0.805228337568632 0.243454251465125 no 2594 0.210343963368872 3873 22530 H1 Histamine receptor antagonist. YIL048W NEO1
SGTC_113 0099-0221 2.5 µM -0.805437021604369 0.243394767779391 no 2595 0.210283767578585 3811 89219
SGTC_463 ikarugamyin 104 µM -0.805966262986734 0.243243947050756 no 2596 0.210131151035421 3876 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis.
SGTC_160 3453-0671 289.699 µM -0.806554736831088 0.243076305866837 no 2597 0.209961530135572 3876 5322268
SGTC_395 anisomycin 6.25 µM -0.806928009027998 0.242970002536585 no 2598 0.209853980383842 3847 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_865 0488-0499 301 µM -0.807599757890509 0.242778760093202 no 2599 0.209660513080029 3793 9634651
SGTC_1954 st077032 68.9 µM -0.807770974144378 0.242730028994295 no 2600 0.20961121865258 3764 698907
SGTC_1115 galangin 695.678 nM -0.809323334360951 0.242288442228573 no 2601 0.209164593814491 3878 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_635 k038-0028 24.7 µM -0.809698880532903 0.242181679230549 no 2602 0.20905663079319 3849 4035102
SGTC_530 4358-1714 28 µM -0.810118063753428 0.242062540901687 no 2603 0.208936161643319 3899 1564641
SGTC_2935 9038016 29.96 µM -0.810367055004513 0.241991788801261 no 2604 0.208864623361031 3856 6463195
SGTC_39 0986-0283 58.349 µM -0.810812098518998 0.241865355422728 no 2605 0.208736792780739 3926 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2
SGTC_2764 methyldopa 94.69 µM -0.813370925370123 0.241139108683883 no 2606 0.208002711886135 3823 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent.
SGTC_1548 st061468 90.8 µM -0.815107646103852 0.240646868423483 no 2607 0.207505347665758 3842 390799
SGTC_1700 st030840 7.9285 µM -0.816726909218749 0.240188412448647 no 2608 0.20704225490294 3917 5499307
SGTC_400 oxethazaine 37.5 µM -0.817206318050352 0.240052770584186 no 2609 0.206905266265534 3878 4621 A local anesthetic.
SGTC_2233 sulbentine 40.3845 µM -0.817674648089078 0.239920303642428 no 2610 0.206771495149473 3835 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58
SGTC_2316 5844804 197.44 µM -0.818905433889682 0.239572366568547 no 2611 0.206420184716502 3920 776813
SGTC_1097 itavastatin 7.23 µM -0.818909841572444 0.239571121033562 no 2612 0.206418927241545 3854 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49
SGTC_1799 st045822 46.1415 µM -0.819730028410092 0.239339411947344 no 2613 0.206185013822049 3810 3674992
SGTC_3340 9146634 11.102 µM -0.821143988020373 0.238940245076781 no 2614 0.2057821283717 3892 4907387
SGTC_1173 0443-0020 122 µM -0.821368288271451 0.238876957623079 no 2615 0.205718260515318 3858 5331295
SGTC_2930 9013230 14.89 µM -0.824111189236926 0.238103776210675 no 2616 0.204938191487885 3902 2995857
SGTC_1121 fusaric acid 630.51 nM -0.824938060565228 0.237870963281749 no 2617 0.204703378330359 3875 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler.
SGTC_2295 7971645 200 µM -0.826515061910234 0.237427290885512 no 2618 0.204255988778077 3920 2978226 YKL099C UTP11
SGTC_3178 9107506 49.47 µM -0.829632081136958 0.236551688976952 no 2619 0.20337341634046 3917 8897194
SGTC_1487 3970-0795 2.82 µM -0.832231308020044 0.235822900860228 no 2620 0.202639197621647 3932 3765103
SGTC_2435 5706476 10.6 µM -0.833620818609272 0.235433809187956 no 2621 0.202247345158771 3885 5725375
SGTC_252 miconazole 1.30953 nM -0.833854071453003 0.235368528318694 no 2622 0.20218161055806 3816 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_1183 1254-0324 198 µM -0.83417490596532 0.235278752144165 no 2623 0.202091214845934 3956 5799357
SGTC_1788 fluconazole 20 µM -0.834271612026246 0.235251695483973 no 2624 0.202063972480294 3929 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11
SGTC_2564 betulinic acid 100 µM -0.834326917210759 0.235236222835279 no 2625 0.20204839384424 3895 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14
SGTC_1428 4049-0204 61.7 µM -0.834654458664306 0.235144598572319 no 2626 0.201956145094111 3937 X1428
SGTC_372 0155-0182 15.9 µM -0.835638786811463 0.234869367831796 no 2627 0.201679070756173 3827 771486
SGTC_1591 genipin 88.4 µM -0.836666459548267 0.234582207470915 no 2628 0.201390038615639 3930 442424 A DNA cross-linking agent.
SGTC_539 4859-0462 2.54 µM -0.836696420506754 0.234573838459593 no 2629 0.201381615846074 3935 46499474 YNL221C | YBR257W POP1 | POP4
SGTC_3186 9110464 49.47 µM -0.837071850046458 0.23446898351694 no 2630 0.20127609117794 3880 17018021
SGTC_1510 1123-0200 71.5 µM -0.83826384753016 0.234136238578375 no 2631 0.200941267696016 3940 5378812 YNL149C | YNL150W PGA2 | YNL150W
SGTC_1564 D-Arginine 115 µM -0.839377769569252 0.233825524821636 no 2632 0.200628677294492 3898 71070 D-isomer of arginine; arginine decarboxylase inhibitor.
SGTC_1557 sumaresinolic acid 42.3 µM -0.841100233187705 0.233345516656897 no 2633 0.200145892245219 3847 9982268 A natural terpine and antifungal of unknown mechanisn.
SGTC_1684 st024538 14.6195 µM -0.842277279991524 0.233017817445171 no 2634 0.199816382694075 3872 6732859
SGTC_1481 3346-2004 36 µM -0.842774285663022 0.232879523882556 no 2635 0.199677345976434 3922 2770522
SGTC_863 0466-0191 129 µM -0.843077956535465 0.232795048848156 no 2636 0.199592423083627 3931 765160 YPR165W RHO1
SGTC_2338 7999974 200 µM -0.843453853382563 0.232690505609785 no 2637 0.199487331989749 3926 315925
SGTC_2788 5282734 71.43 µM -0.843920263190145 0.232560825477274 no 2638 0.199356982112184 3967 743706
SGTC_993 3909-8757 62.7 µM -0.844082527601164 0.232515719060392 no 2639 0.199311645294252 3867 4288324 YLR208W SEC13
SGTC_1976 st070609 63.5 µM -0.8440957269194 0.232512050115193 no 2640 0.199307957666304 3803 682556
SGTC_2216 7189485 200 µM -0.846930037572305 0.231724957718277 no 2641 0.198517059368739 3906 731273
SGTC_1326 1431-2094 10.8 µM -0.8476203363426 0.231533485757677 no 2642 0.198324722502895 3887 616278
SGTC_545 4218-0007 221 µM -0.84820019609313 0.231372715057515 no 2643 0.198163244033401 3883 2840508
SGTC_2090 5301565 104.445 µM -0.848830055250927 0.231198152190006 no 2644 0.19798793177138 3904 2056344
SGTC_1386 3228-0095 33.8 µM -0.849748047994115 0.230943865930601 no 2645 0.197732589471885 3920 870181
SGTC_1697 st025554 27.742 µM -0.849769906248809 0.230937813043859 no 2646 0.197726511962651 3867 1269519
SGTC_331 k048-0133 24.5 µM -0.849961777545953 0.23088468473336 no 2647 0.19767316855983 3874 6813582
SGTC_848 0368-0089 85.6 µM -0.850828801518404 0.230644694762334 no 2648 0.197432229988518 3913 762535
SGTC_1760 st045453 10.4495 µM -0.851113290557507 0.230565979319071 no 2649 0.197353211620562 3967 3323419 YIL048W NEO1
SGTC_135 0933-0004 26.348 µM -0.851292956418062 0.230516275199567 no 2650 0.197303318312678 3900 21230617 YGL099W LSG1
SGTC_2607 solasodine 47.35 µM -0.853124495476516 0.230009926248751 no 2651 0.196795134366825 3927 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity.
SGTC_1956 st077085 54 µM -0.853582643968479 0.229883363493879 no 2652 0.196668139247302 3945 24208685
SGTC_703 3875-0075 71.8 µM -0.854159674199659 0.229724015344409 no 2653 0.196508261707853 3931 2850814
SGTC_1546 5-methoxyflavanone 78.7 µM -0.855717176353322 0.22929421671921 no 2654 0.196077118537162 3895 147795
SGTC_1738 st035555 74 µM -0.856684301027278 0.229027562045241 no 2655 0.195809690898606 3981 5331140
SGTC_2765 myclobutanil 7.74 µM -0.858679807782121 0.22847791307427 no 2656 0.195258596851371 3958 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11
SGTC_1603 st002045 67.8 µM -0.86288617493696 0.227321728469196 no 2657 0.194100026298424 3919 5887985
SGTC_1797 st048695 56.8 µM -0.863209495227488 0.22723299556265 no 2658 0.194011147011152 3896 592262 YIL048W NEO1
SGTC_255 tunicamycin 200.472 nM -0.865272763894752 0.226667206419207 no 2659 0.193444548027954 3867 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_2798 7813637 45.45 µM -0.865976137289014 0.22647450937289 no 2660 0.193251623992693 3944 956368
SGTC_1125 tnp00248 1.32998 µM -0.86614612987498 0.226427951876399 no 2661 0.19320501537994 4025 24207736
SGTC_3231 9132313 49.47 µM -0.866852586895138 0.226234525645535 no 2662 0.193011392324074 3915 4905967
SGTC_264 promethazine 12.5 mM -0.866890917453977 0.226224033501519 no 2663 0.193000890220175 3866 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3
SGTC_3048 9093155 49.47 µM -0.868158517678569 0.22587721085076 no 2664 0.192653779888741 3846 25236002
SGTC_2259 7964009 200 µM -0.870532448553846 0.225228499350272 no 2665 0.192004747200661 3977 313134
SGTC_1366 1683-0113 21.9 µM -0.871088910432125 0.225076590775821 no 2666 0.19185280434362 3934 708623
SGTC_1905 st060207 84.5 µM -0.872115347975444 0.224796535868353 no 2667 0.191572727022829 3871 1948547
SGTC_2191 5911152 200 µM -0.872407654225271 0.224716818710713 no 2668 0.191493013164151 3937 2875902
SGTC_2803 7707263 71.43 µM -0.872461629796989 0.224702100357837 no 2669 0.191478295889751 3907 2199229
SGTC_3125 9127534 49.47 µM -0.872698352920248 0.22463755586475 no 2670 0.191413757854263 3810 1639235
SGTC_811 0416-0114 265 µM -0.873224448220267 0.224494149348062 no 2671 0.191270375762728 4012 6612453
SGTC_1356 1502-0781 85.8 µM -0.873543695719235 0.224407152097975 no 2672 0.191183400107198 3891 567702
SGTC_496 calpeptin 138 µM -0.874593696931696 0.224121154181043 no 2673 0.190897509281138 3958 73364 A calpain inhibitor.
SGTC_134 0269-0018 6.916 µM -0.875177002651388 0.223962363643271 no 2674 0.19073880212555 3898 4378915
SGTC_512 prima-1 270 µM -0.875614307728737 0.223843360102516 no 2675 0.19061987228341 3952 322968 A re-activator of the apoptotic function of mutant p53.
SGTC_67 0335-0847 266 µM -0.876036632804014 0.223728467180895 no 2676 0.190505059632666 4113 4552207 YOR254C SEC63
SGTC_2917 7979103 53.79 µM -0.876847298200662 0.223508020810293 no 2677 0.190284792381137 3997 2980565
SGTC_1742 st038235 28.8875 µM -0.878031890835855 0.223186113719749 no 2678 0.189963206202655 3993 564103 YBR002C RER2
SGTC_2490 carminic acid 95.39 µM -0.878070859528595 0.223175528659439 no 2679 0.189952632892335 3850 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_1691 st019933 84.6 µM -0.878405867520685 0.223084542277858 no 2680 0.189861750657777 3884 6176082
SGTC_1522 st012842 45.6 µM -0.87988982990701 0.222681760121116 no 2681 0.189459497332202 3816 3491067 YOR116C RPO31
SGTC_2715 st079500 56.4 µM -0.880400404855641 0.222543274021327 no 2682 0.189321218635283 3888 28246688
SGTC_2553 4-methylesculetin 85.09 µM -0.882191547052512 0.222057840995537 no 2683 0.188836616152142 3980 5319502
SGTC_994 3910-0338 138 µM -0.882873135792846 0.221873276599099 no 2684 0.188652409865697 4038 3479481
SGTC_822 1487-0950 154 µM -0.88309007249471 0.221814551655624 no 2685 0.188593803763498 3961 1958375
SGTC_450 aminopyrene 156 nM -0.883548551110266 0.221690470331753 no 2686 0.188469981322477 3851 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1
SGTC_175 3793-3120 23.7 µM -0.887459874844389 0.220633534674141 no 2687 0.187415679950187 3966 5322297
SGTC_1686 st019653 115.5 µM -0.887890959056685 0.220517222012362 no 2688 0.187299704202058 3897 97252
SGTC_189 3970-0742 2.116 µM -0.889391756009092 0.220112559818377 no 2689 0.186896287001529 3908 2891807
SGTC_1451 4152-0210 104 µM -0.890868088880255 0.219714909813176 no 2690 0.186499970827988 3936 659563
SGTC_2300 7976697 71.57 µM -0.892510652822601 0.219272970616947 no 2691 0.18605964271682 3868 2236109
SGTC_1832 st054113 55 µM -0.893738452913864 0.218942959449366 no 2692 0.185730923144364 3977 1251267
SGTC_884 0851-0618 334 µM -0.894420667890224 0.218759715552207 no 2693 0.185548429169959 3985 9642473
SGTC_577 r071-0003 38.6 µM -0.894928149135118 0.218623462643932 no 2694 0.185412749048071 3993 4568517 YMR134W ERG29
SGTC_2588 indole-3-carbinol 100 µM -0.894971112669013 0.218611929670104 no 2695 0.185401265151535 4024 3712 Induces cell cycle arrest.
SGTC_2401 5128683 200 µM -0.896015732765066 0.218331623478695 no 2696 0.185122180324106 3960 708373
SGTC_3063 1327-0034 4 µM -0.896025867724998 0.218328904947592 no 2697 0.185119473907008 3872 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_1698 5-fluorocytosine 1.055 µM -0.897926909744155 0.217819327638815 no 2698 0.184612258610017 3998 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_1472 k841-0093 193 µM -0.898264959605468 0.217728784734423 no 2699 0.184522154415711 4066 X1472
SGTC_779 1360-0071 233 µM -0.898368449080012 0.217701070568662 no 2700 0.184494575682817 4036 7566
SGTC_1186 1319-0216 26 µM -0.899227266360438 0.217471160459796 no 2701 0.184265809864297 4028 4565136
SGTC_303 1348-1668 34.2 µM -0.899951533916194 0.217277379043872 no 2702 0.18407302173804 3976 5380509
SGTC_3290 9121031 71.43 µM -0.900078227964129 0.217243491667185 no 2703 0.184039310772132 3986 17014854
SGTC_3098 9119039 49.47 µM -0.901074362580227 0.216977157834269 no 2704 0.183774391530136 3965 17161528
SGTC_1077 5-fluorocytosine 377 nM -0.904574886035066 0.216042730419192 no 2705 0.182845322523994 4000 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_86 0417-1630 471.922 µM -0.905587050736567 0.215772978922694 no 2706 0.18257723265281 3983 3634867
SGTC_1302 1159-0335 255 µM -0.907874490587776 0.215164074162245 no 2707 0.181972268269921 3986 649284
SGTC_2285 7945142 200 µM -0.908259258462041 0.21506174901602 no 2708 0.181870631134967 4037 2970608
SGTC_164 4100-3994 89.624 µM -0.90946132292766 0.214742254138751 no 2709 0.181553332407543 3921 4615967
SGTC_939 1165-0479 45.3 µM -0.909991761636239 0.214601357393393 no 2710 0.181413427257951 3961 1377347
SGTC_715 0868-0130 184 µM -0.911691450055275 0.21415024309101 no 2711 0.180965583032392 4022 2876258
SGTC_1818 st052136 56.3 µM -0.919429427977852 0.212103492739359 no 2712 0.17893550139509 3793 674169
SGTC_1491 4138-0063 26.5 µM -0.922430396985884 0.211312803455899 no 2713 0.178152060222507 3944 23883227
SGTC_2483 5729050 27.16 µM -0.923951103011877 0.210912790955984 no 2714 0.177755887268321 3981 2865180
SGTC_2563 tomatine 8.54 µM -0.924263595278558 0.210830646786929 no 2715 0.177674545959419 3878 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties.
SGTC_2514 salinomycin 42.74 µM -0.924442359804022 0.210783663779066 no 2716 0.177628024360731 4074 23682228 A polyether potassium ionophore.
SGTC_2886 9058944 51.95 µM -0.924780054376411 0.210694927432951 no 2717 0.177540163856379 3855 4949929
SGTC_676 falcarinol 140 µM -0.925270862594082 0.210565996338791 no 2718 0.177412515550493 3967 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer.
SGTC_2006 4011487 200 µM -0.92550520946537 0.210504451767212 no 2719 0.177351587581422 4056 45595294
SGTC_913 3487-1245 167 µM -0.925813135690219 0.210423599713674 no 2720 0.177271549764147 3942 4016153
SGTC_1269 0831-0796 3.05 µM -0.927416496312783 0.210002900700949 no 2721 0.176855164462437 4044 927758
SGTC_263 alizarin 107.927 µM -0.927989862679391 0.209852577578258 no 2722 0.176706414057614 4013 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium.
SGTC_996 3970-0799 1.8 µM -0.928764416630033 0.209649608288349 no 2723 0.176505594511813 4024 6615648 YGL040C HEM2
SGTC_280 3448-3607 3.04 µM -0.929405548064719 0.209481689289726 no 2724 0.176339476824903 3976 626179
SGTC_220 paclitaxel 373.376 µM -0.929733233177967 0.209395895710944 no 2725 0.176254611552633 3971 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_401 neomycin 50 µM -0.930267109352757 0.20925616207085 no 2726 0.176116401418852 3989 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis.
SGTC_2139 5578692 56.4705 µM -0.934229707372443 0.208220731571785 no 2727 0.175092707361945 3965 650991 YMR113W FOL3
SGTC_1958 st076513 41.9 µM -0.934993140025598 0.208021593802195 no 2728 0.174895917371889 3983 732122 YGL099W LSG1
SGTC_2211 7117706 200 µM -0.935297391573509 0.207942262577262 no 2729 0.174817529599425 3941 822771
SGTC_1249 0481-0015 10.2 µM -0.937866983563801 0.207272974253637 no 2730 0.174156386211148 3968 4227577
SGTC_2379 9035213 200 µM -0.938734622847852 0.207047272741832 no 2731 0.17393350625321 3989 646551
SGTC_2628 lathosterol 100 µM -0.940522153703606 0.206582735821416 no 2732 0.173474895768056 4120 6710616
SGTC_746 1095-0025 46.6 µM -0.941324618265052 0.206374395219848 no 2733 0.173269265292829 4044 6749286
SGTC_223 busulfan 5 mM -0.941649455024047 0.206290094590619 no 2734 0.17318607045319 4033 2478 A DNA alkylator.
SGTC_1414 3917-0015 5.4 µM -0.942885308092109 0.205969556416052 no 2735 0.172869785263859 3970 6618702
SGTC_3203 9113543 49.47 µM -0.943004057709422 0.205938772375803 no 2736 0.17283941371281 4118 17018012
SGTC_1974 st069448 26.9 µM -0.951664966311936 0.203700929126155 no 2737 0.170633461090286 4012 6323587 YNR016C ACC1
SGTC_568 1193-0097 7.48 µM -0.953311638884429 0.203277100955002 no 2738 0.170216098075955 3896 3646150
SGTC_2894 9048625 32.47 µM -0.953405597407372 0.203252933359342 no 2739 0.170192303240035 4006 4092861
SGTC_1660 st012960 28.1 µM -0.95528373994527 0.202770205668509 no 2740 0.16971711399465 4036 24207266
SGTC_1139 k015-0024 46.9 µM -0.956579115079161 0.202437662694127 no 2741 0.169389867195208 4068 2766652
SGTC_1653 st012112 65 µM -0.956582361624535 0.202436829665235 no 2742 0.169389047539109 4035 720429
SGTC_3084 9116877 49.47 µM -0.957020373724631 0.202324459229126 no 2743 0.169278485857114 3954 27241325
SGTC_495 decylubiquinone 155 µM -0.958995676871011 0.201818165936294 no 2744 0.168780461531446 4098 2971 A Co-enzyme Q analog. A free radical scavenger.
SGTC_706 4262-0057 46.9 µM -0.962553401563992 0.200908195385376 no 2745 0.167885845995725 4031 883298
SGTC_924 2046-0044 21.3 µM -0.963640318468875 0.200630682889812 no 2746 0.167613142769053 4034 3623589
SGTC_1209 2323-2347 50.3 µM -0.964025857466585 0.200532302085239 no 2747 0.167516481122101 4061 5412760
SGTC_997 3996-0078 137 µM -0.964779110791034 0.200340172540233 no 2748 0.167327730443961 4093 735687
SGTC_2221 6807166 181.081 µM -0.967182821713681 0.19972780681505 no 2749 0.166726324065177 3990 674925
SGTC_524 r073-0010 27.8 µM -0.97121499302901 0.198703109349744 no 2750 0.165720614644741 3970 2772106
SGTC_936 3005-4620 401 µM -0.971918209200085 0.198524725908037 no 2751 0.165545620068951 4105 777207
SGTC_1212 0520-0165 585 µM -0.973304375106543 0.198173382979734 no 2752 0.165201024324811 4220 5403258
SGTC_2304 7443016 91.4 µM -0.973416434911689 0.198144996280952 no 2753 0.165173186966825 3973 939854
SGTC_1306 1185-0270 9.02 µM -0.978232544771288 0.196927313074679 no 2754 0.163979661836855 4090 1548076
SGTC_2912 7964298 10.93 µM -0.979390502493237 0.196635217291958 no 2755 0.163693534022886 4080 2975850
SGTC_2895 9054447 58.44 µM -0.979788351299587 0.196534920214556 no 2756 0.163595301652983 4119 2697450
SGTC_226 1,3-diallylurea 8.28947 mM -0.980630135716979 0.196322809849018 no 2757 0.16338758387324 4025 74537 YKL182W FAS1
SGTC_558 k064-0027 21.3 µM -0.98097416440853 0.196236162471292 no 2758 0.163302741076215 4079 5088526
SGTC_2243 6634756 200 µM -0.982067754606969 0.195960883891128 no 2759 0.163033234958399 4149 885676
SGTC_2931 9014674 55.67 µM -0.985750969778828 0.195035469436186 no 2760 0.162127665510544 4066 2996810
SGTC_1007 4101-0031 70 µM -0.986382577924553 0.194877044031247 no 2761 0.161972705543821 4039 1146276
SGTC_618 k072-0232 33.2 µM -0.986408425549671 0.194870562374208 no 2762 0.161966366092965 4113 5872756 YGL099W LSG1
SGTC_2875 9039966 71.43 µM -0.987528358209887 0.194589849363359 no 2763 0.161691843929247 4088 6463691
SGTC_1502 4534-4282 27.7 µM -0.988451195465268 0.194358723672654 no 2764 0.161465862581455 4025 3278949
SGTC_2186 6124449 200 µM -0.99146275855359 0.193605637572468 no 2765 0.160729834278951 4077 3834182 YLR033W RSC58
SGTC_1113 artemisinin 1.17947 µM -0.992004369145914 0.193470388838842 no 2766 0.160597697047515 4123 2240 An anti-malaria and mitochondrial poison.
SGTC_1418 3966-3099 2.4 µM -0.992281312940191 0.193401253868272 no 2767 0.160530158241604 4088 740335
SGTC_1207 2099-0101 141 µM -0.992337640858935 0.193387194271464 no 2768 0.160516423716786 4098 5837381
SGTC_3131 9127911 49.47 µM -0.994448785039099 0.192860696908828 no 2769 0.160002213701754 4149 45595681
SGTC_2839 9003951 25.97 µM -0.996913079981798 0.192247236169764 no 2770 0.159403351081577 4144 2990634
SGTC_1350 1495-0454 146 µM -0.998342117693341 0.191892039399083 no 2771 0.159056745451404 4145 1069057
SGTC_1619 st003326 88.7 µM -0.998411745126788 0.191874743309966 no 2772 0.159039870305775 4079 2849032
SGTC_3264 9137442 49.47 µM -0.998693417531434 0.19180478305733 no 2773 0.15897161517906 4097 17015726
SGTC_12 0849-0099 9.267 µM -1.00120101958763 0.191182647205784 no 2774 0.158364816866733 3973 6071388
SGTC_2704 st078022 71.1 µM -1.0044968676883 0.190366831734434 no 2775 0.157569590134712 4157 54697681
SGTC_1012 4112-3522 18 µM -1.00614207810734 0.189960396948675 no 2776 0.15717361500084 4125 3112398
SGTC_2349 9023730 187.07 µM -1.00630351006059 0.18992054536078 no 2777 0.157134796264596 4116 4126287
SGTC_3323 9138564 53.9225 µM -1.0088884109763 0.189283129027381 no 2778 0.156514076871438 4117 43912313 YNL103W MET4
SGTC_841 0251-0215 91.2 µM -1.00934983087558 0.189169485178665 no 2779 0.156403444886758 4123 3888614
SGTC_753 1322-0200 289 µM -1.00935217024353 0.189168909119038 no 2780 0.156402884121258 4182 5403907
SGTC_2621 lithochol-11-enic acid 100 µM -1.01000309983492 0.189008662384218 no 2781 0.156246902453558 4028 6708711
SGTC_186 3455-3465 67.277 µM -1.01071177979411 0.188834293692218 no 2782 0.156077198678704 4048 755278
SGTC_46 0329-0187a 2.197 µM -1.01260810177308 0.188368196779941 no 2783 0.155623694247356 4158 46494817
SGTC_2415 st077333 57.7 µM -1.01314821605148 0.188235572067817 no 2784 0.155494685381632 4153 2766255
SGTC_893 0958-0369 48.9 µM -1.01327173596744 0.188205249928975 no 2785 0.155465191977637 4038 6819948
SGTC_2797 7859098 81.82 µM -1.01424649646816 0.187966067769909 no 2786 0.155232573542079 4095 972681
SGTC_2226 7298446 200 µM -1.01430954407121 0.187950603909101 no 2787 0.155217535673966 4085 3283010
SGTC_1881 5652484 16 µM -1.01809616744037 0.187023288940343 no 2788 0.154316128261387 4096 2255129
SGTC_1141 3253-0389 52.6 µM -1.01813467093834 0.187013874289387 no 2789 0.154306980299985 4105 5402031
SGTC_2278 7948257 134.34 µM -1.01878035097353 0.186856040055538 no 2790 0.154153628029531 4106 1247028
SGTC_1215 3852-0577 11.2 µM -1.01978759499763 0.186609987426016 no 2791 0.153914603841774 4156 2884876
SGTC_291 SEC14.278 35.5 µM -1.02085778625398 0.186348777781067 no 2792 0.153660910828226 4154 1068044
SGTC_2442 5158906 48.48 µM -1.02356240206939 0.18568965207556 no 2793 0.153021005720745 4142 1893835
SGTC_2436 5633522 8.09 µM -1.02607296822056 0.18507911321803 no 2794 0.152428595461096 4106 5724242
SGTC_2582 agaric acid 100 µM -1.02669050071201 0.184929128207019 no 2795 0.152283111853155 3851 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase.
SGTC_796 1234-0020 70.7 µM -1.02708700185375 0.184832866660089 no 2796 0.152189749318767 4051 46495034
SGTC_1993 st073995 70.8 µM -1.0270953049503 0.184830851188228 no 2797 0.152187794628262 4093 3098394
SGTC_2742 clothiapine 36.27 µM -1.02763338732325 0.184700267612602 no 2798 0.152061156406267 4100 16351 An atypical antipsychotic. YIL048W NEO1
SGTC_2474 5321570 43.32 µM -1.02809482858287 0.184588329248043 no 2799 0.151952611505483 4127 2841384
SGTC_2450 5739737 12.93 µM -1.03038427589284 0.18403356960653 no 2800 0.151414825796772 4161 2262825
SGTC_1630 st005209 31.3 µM -1.03089769450559 0.183909304959682 no 2801 0.151294398940231 4086 3367314
SGTC_2602 kawain 100 µM -1.03174279580731 0.183704875723962 no 2802 0.151096311757915 4129 5369129
SGTC_2222 6885208 172.143 µM -1.03433392750241 0.183078966294446 no 2803 0.150490040585971 4080 609514
SGTC_79 0052-0007 94.094 µM -1.03452028928698 0.183034000397152 no 2804 0.150446498341312 4129 2801472
SGTC_878 0828-0289 13.7 µM -1.03472183085549 0.182985379634787 no 2805 0.150399418884094 4074 745350 YLR208W SEC13
SGTC_2913 7966556 36.57 µM -1.03598990864987 0.182679647950254 no 2806 0.150103425214304 3994 2976516
SGTC_2998 9066762 71.4286 µM -1.03913645394306 0.181922399144222 no 2807 0.14937063957333 4198 4945196
SGTC_1715 st032160 10.2275 µM -1.03938566145932 0.181862508777856 no 2808 0.149312704923863 4065 5289825
SGTC_1100 amiodarone 5.07 µM -1.03954520215777 0.181824173910014 no 2809 0.149275623493044 4217 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death.
SGTC_488 nitrendipine 139 µM -1.04055147379848 0.181582500750854 no 2810 0.14904188135528 4172 4507 Dihydropyridine L-type calcium channel blocker.
SGTC_3012 9080433 71.4286 µM -1.04062723531738 0.181564313481456 no 2811 0.149024292968153 4137 17688859
SGTC_2911 7942208 15.64 µM -1.0422775458488 0.181168423761155 no 2812 0.148641509801052 4163 1243384
SGTC_2214 7179297 48.276 µM -1.0437090000451 0.180825473300503 no 2813 0.148310022295717 4161 769744
SGTC_1724 st037281 8.293 µM -1.04380810964986 0.180801743509508 no 2814 0.148287089411719 4103 574124 YDL195W SEC31
SGTC_3232 9132874 49.47 µM -1.04381009622329 0.180801267884625 no 2815 0.148286629764499 4090 3784940
SGTC_3103 9120822 49.47 µM -1.04417316454493 0.180714355334054 no 2816 0.148202640143172 4166 17141819
SGTC_812 4251-0442 148 µM -1.04550047125792 0.180396843041445 no 2817 0.147895861447772 4179 5723007
SGTC_45 0kpi-0036 14.9 µM -1.05043119017255 0.179220406530048 no 2818 0.146759955894608 4169 2795021
SGTC_1960 st011366 51.8 µM -1.05220515209302 0.17879833406726 no 2819 0.146352718119283 4150 3972846
SGTC_2042 p-Dimethylaminoacetophenone 200 µM -1.05258073219071 0.178709053954463 no 2820 0.146266595871481 4151 75037 A free radical scavenger.
SGTC_687 k029-0044 34.9 µM -1.05298584104441 0.178612785956478 no 2821 0.146173740703212 4223 5829338
SGTC_1013 4112-3890 241 µM -1.05396332508908 0.178380636138977 no 2822 0.145949854233503 4092 705171
SGTC_2924 9010168 62.78 µM -1.05435751346584 0.178287071279795 no 2823 0.145859633137378 4233 2993929
SGTC_882 0843-0131 351 µM -1.05438382879805 0.178280826153529 no 2824 0.145853611468435 4147 5425421
SGTC_3102 9121669 49.47 µM -1.05469116184677 0.178207900412561 no 2825 0.145783297617078 4177 41905072
SGTC_153 4077-0274 519.67 µM -1.05722364806124 0.177607693580728 no 2826 0.145204764801876 4137 3121976
SGTC_2074 5212007 75.395 µM -1.06037662388806 0.176862213947963 no 2827 0.144486646267012 4032 758611
SGTC_1644 st010134 20.9 µM -1.06098546341488 0.176718489997494 no 2828 0.144348253737976 4132 3818134
SGTC_886 0866-0150 153 µM -1.06215369891205 0.176442920689429 no 2829 0.144082957719463 4223 271463
SGTC_1251 0490-5699 265 µM -1.0622281319843 0.176425372255599 no 2830 0.144066065771458 4209 3883818
SGTC_1344 1488-0097 29.1 µM -1.06477197043342 0.175826297502095 no 2831 0.143489566115805 4184 747966
SGTC_1311 1190-0148 100 µM -1.06477221342248 0.17582624033971 no 2832 0.143489511122686 4215 1961333
SGTC_2437 5741531 144.16 µM -1.06733257265913 0.175224577741513 no 2833 0.14291084219944 4186 2262990
SGTC_2294 7971431 200 µM -1.06740964974387 0.175206485551661 no 2834 0.142893446431688 4148 5741572
SGTC_1756 st041558 35.5 µM -1.06748361247976 0.175189125502234 no 2835 0.142876754896615 4251 3955792
SGTC_2677 mitomycin C 100 µM -1.07086380912673 0.174396912264155 no 2836 0.142115335369947 4204 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_1561 5-methoxyflavone 52.9 µM -1.0731597568655 0.17386011330954 no 2837 0.141599721658733 4098 94525
SGTC_1419 3993-2473 62.6 µM -1.07373676506987 0.173725372590103 no 2838 0.141470339257518 4234 704026
SGTC_1288 0973-0013 65.5 µM -1.07465149052533 0.173511905613788 no 2839 0.141265394814728 4206 4315430
SGTC_693 4161-2696 114 µM -1.07483033608286 0.173470188433713 no 2840 0.141225347962356 4198 805759
SGTC_930 2810-3379 265 µM -1.07541126963412 0.173334725011758 no 2841 0.141095319225427 4214 1015764
SGTC_1517 deoxycholic acid methyl ester 49.2 µM -1.07737427155173 0.17287748614915 no 2842 0.140656546765088 4178 229346 A bile salt which induces apoptosis.
SGTC_2524 avocatin b 10.57 µM -1.07896660633539 0.172507151336424 no 2843 0.140301307207574 4140 6710748
SGTC_1604 st002052 72.4 µM -1.07949452318981 0.172384483641217 no 2844 0.140183666990214 4254 6254834 YHR062C RPP1
SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM -1.08140146180668 0.171941847651194 no 2845 0.139759285845916 4199 551469
SGTC_105 0111-0055 734.78 µM -1.08169319264295 0.171874195543133 no 2846 0.139694439488461 4184 5179370
SGTC_2781 5567276 71.43 µM -1.08270867662224 0.171638838339282 no 2847 0.139468875778313 4216 2853274
SGTC_2264 7948757 110.76 µM -1.0835707725741 0.171439193325642 no 2848 0.139277577817227 4139 2971411
SGTC_2805 7950783 58.44 µM -1.08747048038459 0.17053795036031 no 2849 0.138414468828638 4206 1178958 YDL195W SEC31
SGTC_649 1123-0311 367 µM -1.08763590780029 0.170499786407958 no 2850 0.138377936118962 4074 693629 YIL048W NEO1
SGTC_27 0485-0001 32.618 µM -1.0881281122949 0.170386267631152 no 2851 0.138269277383407 4131 2054479
SGTC_339 3091-4833 71.4 µM -1.09024333745352 0.169898977336705 no 2852 0.13780298387898 4050 3240077
SGTC_2336 9001819 198.65 µM -1.09200893555324 0.169492916463 no 2853 0.137414586826572 4256 2989602
SGTC_2177 5811945 192 µM -1.09339430817493 0.169174738080106 no 2854 0.137110355763538 4240 5343475
SGTC_2633 5,7-dihydroxyisoflavone 100 µM -1.09400442560688 0.169034734193584 no 2855 0.136976518612877 4210 5377381
SGTC_1650 st011916 45.8 µM -1.09407115959651 0.169019425234864 no 2856 0.136961885067323 4117 242528
SGTC_2069 5228469 200 µM -1.09417575517033 0.168995432517496 no 2857 0.136938951317149 4196 2835210
SGTC_61 0978-8327 98.565 µM -1.09523994541796 0.168751446974774 no 2858 0.136705764879431 4112 6150059 YHR072W ERG7
SGTC_2722 naftopidil 47.16 µM -1.09745138468395 0.168245157462844 no 2859 0.136222060742035 4121 4418 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_4 0960-0234 25.671 µM -1.09893542489148 0.167905948011636 no 2860 0.13589811675351 4201 6821112
SGTC_2729 fluphenazine 10.66 µM -1.09972003472017 0.167726786516445 no 2861 0.13572706138371 4115 3372 An atypical antipsychotic.
SGTC_1205 4161-2785 76 µM -1.10014891298545 0.167628906494409 no 2862 0.135633622585278 4257 3498106
SGTC_3040 9091894 49.47 µM -1.10094154583603 0.167448106041506 no 2863 0.13546104935015 4048 25236966
SGTC_2147 5545932 89.7195 µM -1.1027289468981 0.167040859148384 no 2864 0.135072446075629 4210 797404
SGTC_733 4069-0007 56.1 µM -1.10467649303998 0.166597852038119 no 2865 0.13464989635384 4204 5717425 YNL287W SEC21
SGTC_597 k018-0003 82.8 µM -1.10543999687268 0.166424385397759 no 2866 0.134484490404003 4266 6786234
SGTC_1332 1480-0653 17.5 µM -1.10546331380575 0.16641908966997 no 2867 0.13447944120497 4198 5749438
SGTC_2777 climbazole 1.536 µM -1.10732894519286 0.165995721229814 no 2868 0.134075867101825 4053 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2
SGTC_1525 8-methoxypsoralen 92.5 µM -1.10802003216143 0.165839069415752 no 2869 0.133926582321411 4258 4114 Related to psoralen; DNA damaging agent.
SGTC_2376 9072922 81.32 µM -1.11243864799105 0.164839741382681 no 2870 0.132974797646352 4217 17087968
SGTC_1178 0988-0033 191 µM -1.11360165975526 0.164577360740424 no 2871 0.132725057036993 4248 5392207
SGTC_1861 st057647 17.4 µM -1.11393625801917 0.164501924040268 no 2872 0.132653266589709 4297 688668
SGTC_1784 st039334 36.3 µM -1.1144999559222 0.164374886474588 no 2873 0.132532381677996 4266 3496984
SGTC_1410 3909-8106 77.9 µM -1.11598412731731 0.1640407110153 no 2874 0.132214464470249 4262 1039210
SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM -1.11654458439191 0.163914633437428 no 2875 0.132094548521604 4264 368090
SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM -1.11706106784388 0.16379850362887 no 2876 0.131984107631947 4258 91467 include heat shock
SGTC_2848 9016370 25.97 µM -1.11821653143715 0.163538894401989 no 2877 0.131737262743024 4209 7894410
SGTC_2180 6301957 200 µM -1.11893197230501 0.16337828336877 no 2878 0.131584580908275 4233 845462
SGTC_2289 7946404 165.07 µM -1.11913266202635 0.16333324846135 no 2879 0.131541773771138 4216 1246120 YPR165W RHO1
SGTC_3030 9087619 49.47 µM -1.12129515399619 0.16284849550757 no 2880 0.131081123814218 4244 25236973
SGTC_940 3232-1287 54.8 µM -1.12265187898079 0.16254484463209 no 2881 0.130792686386 4191 1585493 YIL048W NEO1
SGTC_589 1227-0070 34.1 µM -1.12446509137188 0.162139602115298 no 2882 0.130407885884986 4282 2841384
SGTC_1257 0669-0121 16 µM -1.12506123923775 0.162006510339228 no 2883 0.130281542419478 4223 4307855
SGTC_2884 9058502 51.95 µM -1.12768164323677 0.161422341475113 no 2884 0.12972719643373 4257 6471554
SGTC_1114 scopoletin 1.73284 µM -1.12886445764952 0.161159106181268 no 2885 0.129477508114316 4247 5280460 A coumarin with genotoxic properties.
SGTC_150 3970-0969 77.2 µM -1.13173251589943 0.160521983533871 no 2886 0.128873453424957 4309 6615640
SGTC_249 wiskostatin 11.211 µM -1.13230716512651 0.160394526654363 no 2887 0.128752659399542 4199 2775510 A n-wasp and actin depolymerizer.
SGTC_2160 5660466 132.927 µM -1.13500392456798 0.159797270520721 no 2888 0.128186837009563 4147 2859134
SGTC_926 2268-1401 59.4 µM -1.13535914811568 0.159718707112927 no 2889 0.12811243445988 4201 2931578
SGTC_1033 k072-0102 21.3 µM -1.13605152222737 0.159565650077975 no 2890 0.127967501019992 4194 5965931
SGTC_553 k007-0256 45.7 µM -1.13794514317908 0.159147534482561 no 2891 0.127571694688839 4291 6287000
SGTC_2646 retinol 96.75 µM -1.1390607721172 0.15890153746715 no 2892 0.127338903798372 4237 445354 A vitamin A analog and teratogen.
SGTC_836 0330-0104 1.35 µM -1.13973945306002 0.158752009785301 no 2893 0.127197432580573 4264 46494820
SGTC_2756 carbadox 75.1 µM -1.14083673678933 0.158510450297689 no 2894 0.126968934895321 4176 2553 A substituted quinoxaline antibiotic. YLR208W SEC13
SGTC_1384 3089-0840 101 µM -1.14120661310033 0.15842907891929 no 2895 0.126891976504847 4213 1069836
SGTC_716 1683-5115 658 µM -1.14161728652602 0.158338764438252 no 2896 0.126806567702856 4206 723597
SGTC_2716 st080858 38.6235 µM -1.14230771059428 0.158187003899206 no 2897 0.12666306866946 4206 5296050
SGTC_2464 5717415 7.67 µM -1.14249140978156 0.158146641483579 no 2898 0.126624907341046 4214 5285744
SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM -1.14361664593594 0.157899551934942 no 2899 0.126391327620305 4254 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_2251 lansoprazole 556 µM -1.14636459808328 0.157297197753314 no 2900 0.125822162240418 4160 3883 Gastric proton pump inhibitor. YBR192W RIM2
SGTC_634 1611-4317 11.2 µM -1.14781554068954 0.156979759719178 no 2901 0.125522360203966 4273 2843522
SGTC_324 1315-0088 19.6 µM -1.14846855145471 0.156837031266163 no 2902 0.125387594194913 4202 6787421
SGTC_2404 5161160 200 µM -1.15329812028651 0.155784085155503 no 2903 0.12439402070529 4186 2831543
SGTC_3082 9117008 49.47 µM -1.15352884373254 0.155733899591026 no 2904 0.124346692807484 4286 41448529
SGTC_1578 josamycin 24.2 µM -1.15382004967237 0.155670573462671 no 2905 0.124286976220702 4252 5282165 A P450 substrate.
SGTC_842 0271-0008 11.1 µM -1.15617264638541 0.155159596749204 no 2906 0.123805272979055 4277 1221709
SGTC_876 0720-0963 56.8 µM -1.15725215380114 0.154925502109636 no 2907 0.123584677676097 4270 765861
SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM -1.15731803237149 0.154911223686854 no 2908 0.123571224431947 4246 1377
SGTC_193 1273-0060 1.558 µM -1.15816124586635 0.154728543616504 no 2909 0.123399120057168 4083 2847393 YHR072W ERG7
SGTC_3143 9086658 49.47 µM -1.15833787036149 0.154690296403855 no 2910 0.123363091336005 4283 25236626
SGTC_1413 3910-0535 34.4 µM -1.15841193251524 0.154674260448194 no 2911 0.123347985971939 4272 2876951
SGTC_1464 k208-0027 110 µM -1.15969121571334 0.154397443099399 no 2912 0.123087273955448 4257 X1464
SGTC_1948 st076329 66.6 µM -1.16197545382901 0.153903983901378 no 2913 0.122622717846183 4155 24208413
SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM -1.16235011447875 0.153823146485576 no 2914 0.122546638944434 4283 4620898
SGTC_1182 1222-0449 220 µM -1.16478684349225 0.153298079585792 no 2915 0.122052642854329 4256 658318
SGTC_2994 9053520 71.4286 µM -1.16644102531088 0.152942313604519 no 2916 0.121718089831126 4297 4647384
SGTC_73 0327-0325 16.231 µM -1.16644263587932 0.152941967485459 no 2917 0.121717764413077 4103 53298
SGTC_3233 9132340 49.47 µM -1.16904525346693 0.152383330667995 no 2918 0.121192699661518 4258 17682950
SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM -1.17046719140751 0.152078692723746 no 2919 0.120906504873802 4243 803109
SGTC_2036 5160441 105 µM -1.17292891268697 0.151552247025736 no 2920 0.120412156988942 4230 134534 YIL048W NEO1
SGTC_392 N-ethylmaleimide 8.33 µM -1.177020872694 0.150679854049996 no 2921 0.119593587667376 4204 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides.
SGTC_2625 euphol 100 µM -1.17728815566602 0.150622986745993 no 2922 0.119540256388203 4275 6708538 A triterpene alcohol.
SGTC_1315 1237-0019 3.69 µM -1.17825796510609 0.150416769472345 no 2923 0.119346890074247 4276 825140
SGTC_403 arphamenine a 50 µM -1.18385246579742 0.149230845816909 no 2924 0.118235734683387 4245 5487158 An arginine aminopeptidase inhibitor.
SGTC_1078 idebenone 36.1 µM -1.18452150637396 0.149089441557718 no 2925 0.118103344065898 4317 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen.
SGTC_1225 1216-0074 20.6 µM -1.18598504280139 0.148780429700852 no 2926 0.117814103185566 4282 4241466
SGTC_3198 9112019 49.47 µM -1.18667550756477 0.14863479331999 no 2927 0.117677819770053 4314 45595555
SGTC_1634 st006576 41 µM -1.19113072964851 0.147697366916461 no 2928 0.116801133949187 4251 3915356
SGTC_2111 5486399 200 µM -1.19222867888977 0.147466956108857 no 2929 0.116585795575566 4232 689674
SGTC_759 3486-0358 89.3 µM -1.19322823285078 0.147257403636861 no 2930 0.116390000214001 4276 875103
SGTC_1387 3342-1166 1.8 µM -1.19372306571099 0.147153737814299 no 2931 0.116293157374054 4248 3418228
SGTC_566 0958-0068 16.5 µM -1.19750437217513 0.146363182434297 no 2932 0.115555012217365 4191 6815365
SGTC_2113 5491891 107.031 µM -1.19774273379347 0.146313444042453 no 2933 0.115508593660774 4280 789979
SGTC_612 0302-0167 22.4 µM -1.19783178139565 0.146294865588581 no 2934 0.115491255924864 4290 235821
SGTC_2318 6029776 164 µM -1.20441970048996 0.144924787593522 no 2935 0.114213700693566 4334 818325
SGTC_2309 7664088 163.95 µM -1.2064012033315 0.144514393274624 no 2936 0.113831416150376 4292 704922
SGTC_1333 1482-0047 286 µM -1.21109168418738 0.143546058428886 no 2937 0.112930134063237 4301 3811116
SGTC_1120 ficusin 1.78878 µM -1.21205520999469 0.1433476851091 no 2938 0.112745623696809 4313 6199 A DNA cross-linker.
SGTC_1347 1493-0251 600 nM -1.21284377478554 0.143185471050662 no 2939 0.112594777739483 4340 3986378
SGTC_533 1222-0222 6.71 µM -1.21541961057271 0.142656465365104 no 2940 0.112103046133052 4324 3982874
SGTC_284 0988-0104 32.6 µM -1.21677828714946 0.142377963655162 no 2941 0.111844291674243 4267 4666532
SGTC_2118 5526350 200 µM -1.21757404697664 0.142215019606877 no 2942 0.111692940925229 4334 743594
SGTC_967 1306-0166 352 µM -1.22223409022989 0.141263337991881 no 2943 0.110809557842237 4322 4437607
SGTC_3281 9140613 49.47 µM -1.22490983031319 0.140718849541142 no 2944 0.110304598087841 4313 16013766
SGTC_2468 5987765 72.9 µM -1.22509383152576 0.140681459395919 no 2945 0.110269934525027 4344 26772094
SGTC_1489 4065-0444 182 µM -1.22579884201902 0.140538259465342 no 2946 0.110137191541785 4313 2877968
SGTC_3056 9094900 49.47 µM -1.22716443300411 0.140261165650444 no 2947 0.109880397216845 4284 25236784
SGTC_1859 st055998 20 µM -1.22883193446319 0.139923314291671 no 2948 0.109567412798134 4266 676301
SGTC_1717 st033143 58.0435 µM -1.23043568765153 0.139598901086502 no 2949 0.109266998122903 4373 674616
SGTC_10 0279-0212 42.575 µM -1.23164089084836 0.139355444938415 no 2950 0.109041629514119 4294 39851 YBR002C RER2
SGTC_2480 5767542 37.17 µM -1.23284389247486 0.13911272174361 no 2951 0.108817005959564 4239 2867358
SGTC_209 4077-0173 175.592 µM -1.23324135359424 0.139032591420785 no 2952 0.108742865489974 4298 15993494
SGTC_2545 solidagenone 89.61 µM -1.23331189062523 0.139018374055327 no 2953 0.108729711650544 4175 6708572 An anti ulcer agent
SGTC_2089 5281248 129.67 µM -1.23416451397278 0.138846598528666 no 2954 0.108570803813235 4301 2737878
SGTC_2068 5226020 147 µM -1.23754837035159 0.138166288427271 no 2955 0.107941784208604 4329 1810509
SGTC_2419 paclitaxel 166.5 µM -1.23851945808515 0.13797147574093 no 2956 0.107761755862044 4249 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_2448 5185112 27.17 µM -1.24036509177563 0.137601734536481 no 2957 0.107420193276903 4329 5718189
SGTC_1853 st056710 91.2 µM -1.24139541472509 0.1373956213446 no 2958 0.107229856090523 4380 269167
SGTC_2949 9072542 2.23 µM -1.24206951150386 0.137260884329394 no 2959 0.107105458176562 4338 16457352
SGTC_1560 lithocholic acid 53.1 µM -1.24232341043307 0.137210158961464 no 2960 0.107058630626054 4244 9903 A bile acid which acts as a detergent.
SGTC_1811 st050069 61.5 µM -1.24760477041453 0.136157921770649 no 2961 0.106087915320162 4303 3877702
SGTC_2525 harmine 47.85 µM -1.2493936944817 0.135802759077759 no 2962 0.105760556783409 4311 5280953 A monoamine oxidase inhibitor
SGTC_1434 4073-0095 163 µM -1.25100699454862 0.135483008303528 no 2963 0.105465962774257 4314 24133745
SGTC_3333 9141820 12.094 µM -1.25722376008256 0.134255692348031 no 2964 0.104336310955475 4315 1939433
SGTC_1052 3253-3998 198 µM -1.26079177166866 0.133554753580222 no 2965 0.103691939572961 4276 5450317
SGTC_2056 5235370 200 µM -1.26170701662253 0.133375359273508 no 2966 0.103527115577748 4249 5511916
SGTC_3342 9147791 14.508 µM -1.26339702709605 0.133044541400936 no 2967 0.103223266009153 4298 1838168
SGTC_514 4466-0038 2.65 nM -1.26811391746061 0.132124204656729 no 2968 0.102378636054804 4141 5722064
SGTC_1710 st031758 61.5 µM -1.26828091722212 0.13209170113114 no 2969 0.102348824635829 4379 5394341
SGTC_2916 7875993 68.79 µM -1.26893840620308 0.131963786214264 no 2970 0.102231516484354 4187 1299250
SGTC_1160 4092-0570 10.5 µM -1.26979602486501 0.131797064371962 no 2971 0.102078648535044 4333 4994975
SGTC_2675 theaflavin digallate 100 µM -1.2714324552503 0.131479344157834 no 2972 0.101787421306637 4274 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative.
SGTC_3235 9132602 49.47 µM -1.27293462491007 0.131188157053979 no 2973 0.101520620636187 4339 4912240
SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM -1.27362811578807 0.131053878158636 no 2974 0.101397621560415 4319 6857784
SGTC_1678 st019265 80.2 µM -1.27379204060666 0.131022151688137 no 2975 0.101368563361288 4329 5367020
SGTC_381 3461-2219 42.7 µM -1.27468056485349 0.130850276542239 no 2976 0.101211164304022 4334 2883159
SGTC_1707 st032323 6.317 µM -1.27639911407498 0.130518284600558 no 2977 0.100907234629471 4199 3132057 YMR211W DML1
SGTC_2754 granisetron 64.02 µM -1.28047082625269 0.12973403148558 no 2978 0.100189799313929 4357 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients.
SGTC_922 1866-0035 480 µM -1.2814338933142 0.129549013219609 no 2979 0.100020652837318 4269 3156169
SGTC_658 3253-0951 102 µM -1.28192813849001 0.129454133017044 no 2980 0.0999339280221646 4347 1184878
SGTC_1711 st032263 62.8 µM -1.2900123767217 0.127909034807521 no 2981 0.0985231804402025 4349 3958979
SGTC_1872 amphotericin b 148 nM -1.29053451804778 0.127809683074981 no 2982 0.0984325675045308 4369 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1
SGTC_3015 9080845 49.47 µM -1.29068003071448 0.127782004850562 no 2983 0.0984073259648292 4401 5296973
SGTC_2433 5607874 27.82 µM -1.29163701078748 0.12760007974867 no 2984 0.0982414402812036 4320 2252428
SGTC_2573 2',4'-dihydroxychalcone 15.04 µM -1.29373745887599 0.127201409145763 no 2985 0.0978780608973647 4319 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_2528 xanthyletin 44.79 µM -1.29497455810336 0.12696701036443 no 2986 0.0976645031326441 4391 65188 An natural product with antifungal activity of unknown mechanism.
SGTC_2188 6126565 140.678 µM -1.29672808527283 0.126635277007545 no 2987 0.097362381167561 4259 874518
SGTC_1997 st073024 93.8 µM -1.29837997569719 0.12632332397168 no 2988 0.0970783982927696 4392 686268
SGTC_3274 9138298 49.47 µM -1.29849014454311 0.126302538081346 no 2989 0.0970594803879938 4337 17015756
SGTC_358 0075-0058 9.45 µM -1.30073642428419 0.125879245340662 no 2990 0.0966743449938852 4327 1069125
SGTC_2849 9019321 12.99 µM -1.30536637425563 0.125009893556627 no 2991 0.0958840613235885 4393 16489627
SGTC_787 4152-0075 138 µM -1.30607997732125 0.124876276363659 no 2992 0.0957626806277518 4385 9566539
SGTC_110 0850-0284 111.64 µM -1.31076815543152 0.124000928858122 no 2993 0.0949680521566936 4242 3906265
SGTC_349 k015-0014 24 µM -1.31425842724851 0.123352041457852 no 2994 0.0943796261655448 4384 2196908
SGTC_1295 1013-0063 9.78 µM -1.31677234390077 0.122886147583028 no 2995 0.0939574728607811 4402 6826038
SGTC_1824 st053723 68.6 µM -1.3207585266903 0.12214993655454 no 2996 0.0932909461752653 4389 675225
SGTC_3341 9147222 25.867 µM -1.3211640781503 0.122075208888345 no 2997 0.0932233304984847 4382 1939759
SGTC_1210 3013-0140 750 nM -1.32344987770152 0.121654623604434 no 2998 0.0928429070718685 4407 905973
SGTC_1936 st074407 74.3 µM -1.32413788835647 0.121528229812943 no 2999 0.0927286271739705 4408 809813
SGTC_2073 5212005 126 µM -1.3242153372961 0.121514007523286 no 3000 0.0927157692728999 4276 691789
SGTC_1046 2001-0062 216 µM -1.3285508322801 0.120719726684768 no 3001 0.0919981012607373 4328 739778
SGTC_1086 cerivastatin 2.18 µM -1.33049080916157 0.120365500931684 no 3002 0.0916783062765628 4382 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7
SGTC_617 3770-0098 35 µM -1.3338282574514 0.119757821451818 no 3003 0.0911300739645597 4308 5962639
SGTC_3257 9139206 32.98 µM -1.34207152895361 0.118266174136465 no 3004 0.0897864021353842 4398 4910041
SGTC_2772 vinpocetine 57.06 µM -1.34227621221332 0.118229303912831 no 3005 0.0897532266958708 4410 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor.
SGTC_1055 3448-0672 86 µM -1.34236369367476 0.118213548088223 no 3006 0.089739050319538 4368 748378
SGTC_2000 st075254 36.4 µM -1.3437281666001 0.117967992224906 no 3007 0.0895181528087883 4286 17234175
SGTC_1514 1189-1591 158 µM -1.34452774069072 0.117824265546599 no 3008 0.0893888960622564 4407 767698 YMR146C TIF34
SGTC_3345 9148410 3.559 µM -1.34628293362967 0.117509197163801 no 3009 0.08910564380281 4344 4903596
SGTC_318 1488-0629 67.2 µM -1.34724667848352 0.117336452687051 no 3010 0.0889503994474107 4445 3662576
SGTC_2627 acetyl isogambogic acid 100 µM -1.34962459617878 0.116910997229653 no 3011 0.0885682152092001 4405 6857789 A caspase activator and apoptosis inducer.
SGTC_1424 4048-1941 275 µM -1.35087461252564 0.116687784104811 no 3012 0.0883678009679005 4473 X1424
SGTC_1906 st060206 94.7 µM -1.35294600013153 0.116318565770829 no 3013 0.0880364411396674 4425 5133468
SGTC_132 0417-1715 25.805 µM -1.35415595927548 0.116103278245688 no 3014 0.0878433131239465 4390 6769098
SGTC_2871 9038510 12.99 µM -1.35463286775264 0.116018499874001 no 3015 0.0877672781086537 4387 4945164
SGTC_1357 1503-1303 39.5 µM -1.35630118315617 0.11572227499232 no 3016 0.0875016796030126 4385 292895
SGTC_1364 1653-0028 37.6 µM -1.3567167983192 0.115648562320657 no 3017 0.0874356064243709 4395 5718652
SGTC_99 0109-0120 622.8 µM -1.35689160632513 0.115617568689962 no 3018 0.0874078271307651 4409 759414
SGTC_2207 7258803 200 µM -1.35739157541806 0.115528956254222 no 3019 0.0873284118256678 4421 3666799
SGTC_1224 0823-0416 294 µM -1.35746032964728 0.115516774316695 no 3020 0.0873174950887424 4431 3598164
SGTC_1642 st009582 77.7 µM -1.35932035521049 0.115187559552167 no 3021 0.0870225483074371 4387 6739311
SGTC_2789 5281112 71.43 µM -1.36082780860384 0.114921237993221 no 3022 0.0867840558214056 4410 765948
SGTC_2179 6298986 200 µM -1.36928395113981 0.113435410928025 no 3023 0.0854552663363313 4387 738374
SGTC_20 0481-0013 4.944 µM -1.37036168621952 0.113247031135585 no 3024 0.0852870129320944 4455 182045
SGTC_1024 4507-0395 26 µM -1.37165102971783 0.113021957163668 no 3025 0.0850860499419024 4469 4201836
SGTC_2009 4012297 12.05 µM -1.37458641855673 0.112510732854063 no 3026 0.0846298507783527 4385 45595307
SGTC_639 0833-0042 114 µM -1.37467306330534 0.112495668032476 no 3027 0.0846164129409519 4436 5978911 YPR085C | YHR062C ASA1 | RPP1
SGTC_1556 plumbagin 1.48 µM -1.37495889368558 0.112445981254418 no 3028 0.0845720945143368 4345 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_2552 juarezic acid 87.02 µM -1.37889846558266 0.111762750031807 no 3029 0.0839630306726323 4364 1549512
SGTC_3055 9094636 49.47 µM -1.3851296891901 0.110688154276979 no 3030 0.0830064075696451 4452 25236176
SGTC_453 enantio-paf c16 10 µM -1.38593158141338 0.110550404811528 no 3031 0.0828838981239589 4097 13871343 A lipid and platelet activating factor
SGTC_1629 st005085 44.9 µM -1.39215210951978 0.109486011772579 no 3032 0.0819381706663354 4383 24207091
SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM -1.39498345126647 0.109003986596588 no 3033 0.0815104149844409 4458 6710655
SGTC_3309 9129340 25.759 µM -1.3955744219104 0.108903568801454 no 3034 0.0814213446645013 4432 17158987
SGTC_550 4123-0385 25.7 µM -1.40102138435789 0.107981150567071 no 3035 0.0806038392565987 4453 5731123
SGTC_2344 7990960 76.95 µM -1.40394356810884 0.107488617049553 no 3036 0.0801678272685765 4418 140813
SGTC_292 k038-0015 474 µM -1.40417141619486 0.107450281453488 no 3037 0.0801339056724382 4429 46368540
SGTC_1230 0170-0365 3.77 µM -1.4066475513723 0.107034305347971 no 3038 0.0797659626724737 4469 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1
SGTC_3061 glucosamine 200 µM -1.40745004877227 0.106899740066642 no 3039 0.0796469896286127 4374 91431 and experimental redox chemotherapeutic
SGTC_162 k030-0015 37.8 µM -1.40856694487883 0.106712658632693 no 3040 0.0794816293933828 4493 1809920 YMR134W ERG29
SGTC_2465 5809242 33.21 µM -1.40956444783501 0.106545775541312 no 3041 0.0793341654710257 4502 2731748
SGTC_1734 st037168 69.4 µM -1.40971615558503 0.10652041122071 no 3042 0.0793117562046574 4444 708907
SGTC_2091 4-phenylthiadiazole 200 µM -1.41057255501231 0.106377309854553 no 3043 0.0791853444044308 4455 270010
SGTC_3291 9121177 71.43 µM -1.41343836830101 0.105899452069915 no 3044 0.0787634354452353 4431 17015612
SGTC_1840 st055363 71 µM -1.41450532881663 0.105721939483484 no 3045 0.0786067919385389 4468 676033
SGTC_128 0906-2981 13.371 µM -1.4164319773243 0.105401943820059 no 3046 0.078324533495487 4431 6740226
SGTC_272 doxorubicin 8.13 µM -1.41783959073672 0.10516859764093 no 3047 0.0781188012449249 4488 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_1968 st069590 43.6 µM -1.41961012236533 0.104875620071642 no 3048 0.0778606084364731 4408 6384066
SGTC_2174 5790901 200 µM -1.42038891603553 0.104746936996225 no 3049 0.0777472439330813 4422 786020
SGTC_2969 9091408 28.7 µM -1.42339845303407 0.104250734355316 no 3050 0.077310340343403 4372 4286311
SGTC_2244 6635614 200 µM -1.42536245580974 0.103927836042021 no 3051 0.0770262274432611 4390 836499
SGTC_2905 7799065 20.05 µM -1.42583701260943 0.103849923893083 no 3052 0.0769576971770239 4334 1296806
SGTC_200 k038-0079 37.545 µM -1.42679706795451 0.103692432760608 no 3053 0.0768191982898503 4451 3436683
SGTC_690 glyoxal 20.3 µM -1.42711569093312 0.103640202952062 no 3054 0.0767732752138726 4253 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins.
SGTC_2770 toltrazuril 17.5 µM -1.42864465375721 0.103389835518594 no 3055 0.0765531964353491 4396 68591 Kills coccidiodes.
SGTC_2723 salbutamol 83.58 µM -1.43243879317279 0.102770442959208 no 3056 0.0760091415253111 4451 9884233 β2-adrenoceptor agonist
SGTC_2181 6316240 54.2555 µM -1.43425252466099 0.102475306096776 no 3057 0.0757501064910051 4456 12779990
SGTC_111 0083-0039 52.457 µM -1.43917078450226 0.101678091593733 no 3058 0.0750510703769283 4419 759313
SGTC_1795 st049545 62.3 µM -1.44230024631784 0.101173184740354 no 3059 0.0746088453700334 4398 5291882
SGTC_3161 9100388 49.47 µM -1.44242101617022 0.101153736434066 no 3060 0.0745918192938811 4530 25236368
SGTC_1569 carminic acid 40.6 µM -1.44488209611937 0.100758006999697 no 3061 0.074245503045963 4545 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_2368 9071271 200 µM -1.44526979158968 0.100695770571083 no 3062 0.0741910597677496 4435 27209959
SGTC_1408 3909-7976 48.8 µM -1.44639942997568 0.100514590542564 no 3063 0.074032600826818 4506 24152374
SGTC_2432 5630864 12.22 µM -1.4470378936453 0.10041229412405 no 3064 0.0739431553880731 4461 5714970
SGTC_964 1287-0107 19.4 µM -1.4479091828036 0.100272816366507 no 3065 0.0738212255738978 4445 51516812 YPR165W RHO1
SGTC_3170 9103054 49.47 µM -1.45130046320623 0.0997312795816771 no 3066 0.0733481061908583 4445 16432970
SGTC_2086 5274770 176.623 µM -1.45460418591292 0.0992057821202924 no 3067 0.0728894357548057 4511 689278
SGTC_2731 amoxapine 43.43 µM -1.45783605637075 0.0986936756334906 no 3068 0.0724428686089835 4627 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine.
SGTC_454 lyso-paf C-16 6.67 µM -1.45819464372973 0.0986369750883186 no 3069 0.0723934498839386 4488 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_1031 k035-0009 16 µM -1.45875379541039 0.0985486084988217 no 3070 0.0723164419283299 4507 5180959
SGTC_1034 k072-0165 12.7 µM -1.45928641584177 0.0984644887350908 no 3071 0.0722431463209817 4491 5835461
SGTC_2546 rhodinyl acetate 100 µM -1.46120797546773 0.0981614429236192 no 3072 0.0719791874906522 4421 6708682
SGTC_3147 9097027 49.47 µM -1.4614716824166 0.0981199075384477 no 3073 0.0719430206437891 4482 25236841
SGTC_353 1988-1175 58.3 µM -1.46229021045681 0.097991066602016 no 3074 0.0718308500129019 4290 2788357
SGTC_1945 st075991 56.6 µM -1.46317337352966 0.0978521908410797 no 3075 0.0717099723214178 4456 1084980
SGTC_1044 1222-0021 1.78 µM -1.46428365151739 0.0976778064329916 no 3076 0.0715582310894778 4395 4306703
SGTC_2035 5154463 94.595 µM -1.46507844700574 0.0975531128987518 no 3077 0.0714497581167011 4488 2769623
SGTC_1680 diphenhydramine 100 µM -1.46554375210346 0.0974801665099461 no 3078 0.0713863122859712 4441 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1
SGTC_895 0964-0006 13.7 µM -1.46576772391687 0.0974450684707053 no 3079 0.0713557884370788 4467 6738897
SGTC_1891 st059073 26.2 µM -1.47022080000991 0.096749161675843 no 3080 0.0707509815345275 4544 688754
SGTC_3172 9105863 49.47 µM -1.4754498819196 0.0959366517153745 no 3081 0.0700458165283873 4575 2348785
SGTC_1089 terbinafine 2.25 µM -1.48063572808276 0.0951358271341256 no 3082 0.069351834663224 4486 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_616 4092-0450 108 µM -1.48155256578149 0.0949947580496991 no 3083 0.0692296941612535 4486 787165
SGTC_2014 4013930 200 µM -1.48205117392107 0.0949181045051554 no 3084 0.0691633395283034 4462 64556
SGTC_1994 st072947 40.9 µM -1.48579242980634 0.0943443956730602 no 3085 0.0686670165687117 4534 5286565 YDL195W SEC31
SGTC_2685 mycophenolic acid 18.85 µM -1.48636079239425 0.0942574634434842 no 3086 0.0685918573176373 4488 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_2397 5161689 200 µM -1.48852964711975 0.0939262755253943 no 3087 0.068305634784976 4507 2259942
SGTC_2650 prasterone 100 µM -1.4899885705975 0.0937039790048329 no 3088 0.0681136205851207 4503 16759247 A steroid and weak partial agonist of the androgen receptor.
SGTC_2275 7947463 200 µM -1.50058265969931 0.0921013954761397 no 3089 0.0667317695578457 4447 1225414
SGTC_1119 parthenolide 318.541 nM -1.503731201898 0.0916290449819157 no 3090 0.0663252959123951 4539 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs.
SGTC_2121 5257820 149.641 µM -1.50413004769882 0.0915693376765686 no 3091 0.0662739424330705 4520 791256
SGTC_1116 jasmonic acid 1.58368 µM -1.50612333206454 0.0912713746115798 no 3092 0.0660177580344575 4528 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid.
SGTC_1390 3413-2614 145 µM -1.50826457441555 0.0909520958098465 no 3093 0.0657434130502691 4485 3421432
SGTC_1977 st070720 65.3 µM -1.50892661625711 0.0908535472076936 no 3094 0.0656587685688376 4520 682188
SGTC_180 1486-1293 102.781 µM -1.50966584652175 0.0907436023269206 no 3095 0.0655643551321553 4424 4140536
SGTC_1551 6-bromo-3'-methylflavone 63.5 µM -1.51387908258122 0.0901188569754593 no 3096 0.0650282551289048 4495 688751
SGTC_995 3931-2021 34.6 µM -1.51581041817844 0.0898335459108179 no 3097 0.0647836484762466 4518 730143
SGTC_2647 atorvastatin 60.16 µM -1.51593137996026 0.0898156989163672 no 3098 0.0647683522856121 4480 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7
SGTC_1219 1469-0211 33.1 µM -1.51897341749793 0.0893677354717311 no 3099 0.06438459361602 4502 6822282
SGTC_843 0310-0051 143 µM -1.52282149018518 0.0888034607987788 no 3100 0.0639016859606555 4528 2065037
SGTC_1082 camptothecin 424.86 nM -1.52628956476989 0.0882971851622685 no 3101 0.0634688831608845 4380 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_3187 9109394 49.47 µM -1.52905416367252 0.0878951474370214 no 3102 0.0631255085297155 4508 17098090
SGTC_2750 bromebric acid 70.15 µM -1.5295863924699 0.0878179058083364 no 3103 0.0630595698843973 4509 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2
SGTC_2718 lomofungin 53.02 µM -1.53154807486163 0.08753364675743 no 3104 0.0628169971985639 4483 5351222 A RNA synthesis inhibitor.
SGTC_2644 guaiazulene 100 µM -1.53215190122891 0.0874462872048292 no 3105 0.0627424773152778 4544 3515 A coloring agent.
SGTC_1744 st037937 38.9 µM -1.53283032705513 0.0873482125031536 no 3106 0.0626588331111165 4536 1016152
SGTC_1553 gossypol 38.6 µM -1.53704940253683 0.0867401362939027 no 3107 0.0621406060017982 4439 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_1814 st052110 31.539 µM -1.53820599558596 0.0865739955416569 no 3108 0.0619991277499145 4451 674163
SGTC_268 camptothecin 39.6153 µM -1.53954645329329 0.0863817409784628 no 3109 0.0618354731744486 4471 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_2162 5663267 200 µM -1.54112956181803 0.0861550957021768 no 3110 0.0616426281980047 4526 6456493
SGTC_3127 9126946 49.47 µM -1.54113979251475 0.0861536324754762 no 3111 0.0616413834836077 4460 27243249
SGTC_2832 7992762 51.95 µM -1.5412466437829 0.0861383513790945 no 3112 0.0616283846315567 4442 2985177
SGTC_44 0929-0055 61.211 µM -1.54197035212786 0.0860349052098251 no 3113 0.0615403991701863 4387 1379590
SGTC_2692 st077426 47.7 µM -1.54355776126694 0.0858083280740663 no 3114 0.0613477521432899 4505 25238571
SGTC_2694 st077685 81.9 µM -1.55132161849517 0.0847065929946196 no 3115 0.0604123142753811 4447 2838096
SGTC_191 3914-0123 66.505 µM -1.55334541234006 0.0844211558854184 no 3116 0.0601703182732842 4585 3144412
SGTC_1368 1852-0141 284 µM -1.55426142560538 0.0842921983190955 no 3117 0.060061035384498 4505 2838987
SGTC_2117 5521686 200 µM -1.55896807105081 0.0836319209591095 no 3118 0.0595019687011031 4517 803312
SGTC_896 0964-0007 44.5 µM -1.56211216175066 0.0831930183337371 no 3119 0.0591307841682036 4488 6756758
SGTC_1495 4469-0029 237 µM -1.56245200218223 0.0831456818656892 no 3120 0.0590907723442032 4525 793680
SGTC_2659 sanguinarine 24.21 µM -1.56383257865942 0.0829535892381234 no 3121 0.0589284456233862 4492 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis.
SGTC_360 0957-0399 1.01 µM -1.56886025760013 0.0822568619170926 no 3122 0.0583402520146831 4542 6752301 YPR165W RHO1
SGTC_464 bw-b 70c 158 µM -1.57138856621392 0.0819081628629708 no 3123 0.0580462100927763 4526 5353454
SGTC_310 1273-0058 1.06 µM -1.58003375459661 0.080724251374499 no 3124 0.0570495682774771 4249 2734232
SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM -1.58608200269193 0.0799036909378498 no 3125 0.0563603544435616 4514 688761
SGTC_382 3229-0966 23.2 µM -1.5915652465284 0.079165249629873 no 3126 0.0557412120606169 4567 5722370
SGTC_2491 paeonol 100 µM -1.59435179563314 0.0787919644098578 no 3127 0.0554286313316458 4516 11092 Increases levels of cortical cytochrome oxidase.
SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM -1.59698148335979 0.0784409168638724 no 3128 0.0551349173967479 4569 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair.
SGTC_3206 9114350 49.47 µM -1.59714854012343 0.0784186559092757 no 3129 0.0551163001797166 4412 17087243
SGTC_217 ketoconazole 989 nM -1.60071127779051 0.0779450470102058 no 3130 0.0547204410562758 4350 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4
SGTC_986 1493-0483 84 µM -1.60086801844501 0.0779242608049104 no 3131 0.0547030772094338 4514 40079
SGTC_57 miconazole 162.5 nM -1.60218518025618 0.0777497511914623 no 3132 0.0545573330993456 4382 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_2876 9059903 25.97 µM -1.60236445452518 0.0777260222543954 no 3133 0.0545375201439647 4539 6916095
SGTC_1661 st013063 9.66 µM -1.60342791142826 0.0775853749566919 no 3134 0.0544201064476574 4617 721395
SGTC_1280 0880-0253 10.1 µM -1.60539767023412 0.0773253754267036 no 3135 0.0542031584028003 4528 6836607
SGTC_346 4513-0042 7.16 µM -1.60761096847498 0.0770340200122736 no 3136 0.0539602042329645 4488 2827372
SGTC_2493 resveratrol 26.09 µM -1.61314477172988 0.0763092095570228 no 3137 0.0533565294191717 4511 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase.
SGTC_1148 3909-7663 27.7 µM -1.6144308938278 0.076141500529799 no 3138 0.0532169975766525 4580 4084526
SGTC_1925 st057770 10.1 µM -1.61568022715691 0.0759788575025266 no 3139 0.0530817340816485 4547 5989122
SGTC_2986 9022445 71.43 µM -1.61691151593367 0.0758188225379857 no 3140 0.052948691121824 4520 6459286
SGTC_1043 0916-0009 19.3 µM -1.6173960879671 0.0757559114397164 no 3141 0.0528964048227316 4560 3101130
SGTC_827 3253-0474 693 µM -1.62123968327472 0.075258312228773 no 3142 0.0524831225851387 4558 5402065
SGTC_3298 9116858 71.43 µM -1.62624214739153 0.0746144204184964 no 3143 0.0519490766871727 4601 2506942
SGTC_1594 piperine 70.1 µM -1.63121783379148 0.0739781546471668 no 3144 0.0514221817910761 4546 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_615 k087-0205 167 µM -1.63151566377276 0.0739402015498547 no 3145 0.0513907787251377 4574 9642773
SGTC_2 0422-0095 29 µM -1.6337911890478 0.0736507175358271 no 3146 0.0511513515223674 4480 6790840
SGTC_1507 4075-3230 155 µM -1.63416539281273 0.0736031957714841 no 3147 0.0511120635107673 4522 659771
SGTC_1570 verbenone 133 µM -1.63824873400055 0.0730861570921767 no 3148 0.0506849086130078 4578 29025 A natural terpanoid with antifungal properties.
SGTC_2851 9015922 71.43 µM -1.63921055041386 0.0729647758889713 no 3149 0.0505847086614165 4563 2996893
SGTC_1026 k007-1105 30.6 µM -1.64610175335116 0.0720996149931683 no 3150 0.0498714057641041 4532 7066794
SGTC_256 clotrimazole 625 nM -1.64627363682723 0.0720781367185032 no 3151 0.0498537173246546 4508 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C
SGTC_2959 9079155 11 µM -1.64814893920887 0.0718441206204397 no 3152 0.0496610558946424 4568 16189457
SGTC_1640 st009078 66.4 µM -1.64816567475573 0.071842034843657 no 3153 0.0496593392266052 4543 690618
SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM -1.65135105410763 0.0714458811546335 no 3154 0.0493334565167608 4545 521171
SGTC_536 3852-0578 10.6 µM -1.66461760564866 0.0698139808141338 no 3155 0.0479945353118113 4584 2869208
SGTC_2720 fluspirilene 36.88 µM -1.67445272473378 0.0686228073526981 no 3156 0.047020829053215 4563 3396 An atypical antipsychotic.
SGTC_3347 9188721 44.724 µM -1.67944102411281 0.068024674999882 no 3157 0.0465330618445278 4581 44118411 YKL104C | YBL026W GFA1 | LSM2
SGTC_3316 9136639 10.545 µM -1.68125216160303 0.0678085056144359 no 3158 0.0463569728083542 4565 4903665
SGTC_902 1120-0002 2.07 µM -1.68975959779598 0.0668001883047911 no 3159 0.0455369780980138 4567 3280475
SGTC_1996 st072960 66.8 µM -1.691788826365 0.0665614025299969 no 3160 0.0453431224010626 4612 1719405
SGTC_1815 st051655 58.2 µM -1.69201099918682 0.0665352989284224 no 3161 0.0453219382275833 4554 5984156
SGTC_3021 9087658 49.47 µM -1.69229725913038 0.0665016772657029 no 3162 0.0452946550865651 4610 25237042
SGTC_829 1635-0120 117 µM -1.6971348302895 0.0659354843455154 no 3163 0.0448355862804375 4569 285054
SGTC_1791 st048313 56.1 µM -1.70580565189593 0.0649300019178702 no 3164 0.0440221352391713 4602 1204976
SGTC_2586 curcumin 80 µM -1.71124531083418 0.0643053122270049 no 3165 0.0435179187008674 4486 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40
SGTC_627 1391-0720 175 µM -1.71442847846563 0.0639419299448542 no 3166 0.0432250310006328 4587 997839
SGTC_3032 9089427 49.47 µM -1.7160953864532 0.0637522780944769 no 3167 0.0430722927573591 4565 17173707
SGTC_3110 9122132 49.47 µM -1.71818143176026 0.0635155558385037 no 3168 0.0428817636424615 4608 918317
SGTC_570 0987-0065 62.6 µM -1.71837471125782 0.0634936573539451 no 3169 0.0428641449745 4504 3104428
SGTC_636 0kpi-0074 126 µM -1.72362286577717 0.0629012867690238 no 3170 0.0423879739538052 4619 616434
SGTC_2744 captopril 92.04 µM -1.72395090655507 0.0628644035534034 no 3171 0.0423583530955279 4648 44093 angiotensin-converting enzyme (ACE) inhibitor
SGTC_1000 4048-0884 8.67 µM -1.72764563360897 0.0624501502489642 no 3172 0.0420258880530423 4588 13040088
SGTC_1527 coumarin 137 µM -1.72794591544471 0.0624165763504169 no 3173 0.0419989606668943 4627 323 A hepatotoxic, DNA x-linker.
SGTC_2596 sinensetin 100 µM -1.72967127521703 0.0622239400868108 no 3174 0.041844511812006 4589 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets.
SGTC_894 0960-0238 55.9 µM -1.73174504966275 0.0619930173885451 no 3175 0.041659482902184 4599 6741907 YDL195W SEC31
SGTC_689 0833-0039 98 µM -1.73175101803801 0.0619923537536047 no 3176 0.0416589513423006 4564 5374726
SGTC_3329 9141233 27.5565 µM -1.7356792322423 0.0615567694708405 no 3177 0.0413102837922761 4569 4909101 YNL103W MET4
SGTC_1330 1469-0054 61.8 µM -1.75966160383594 0.0589490951691123 no 3178 0.0392325998270597 4575 7102664
SGTC_2966 9084041 48.03 µM -1.7630790040644 0.0585846724370427 no 3179 0.0389435829195478 4564 17741380
SGTC_2158 5657123 3.6195 µM -1.77124426692789 0.0577211114720023 no 3180 0.0382600454738625 4622 2858827
SGTC_1377 2944-0135 198 µM -1.77424007718769 0.0574067950548766 no 3181 0.0380117238254593 4615 1894137
SGTC_2131 toluylene red 5.2905 µM -1.77443094731144 0.057386814936409 no 3182 0.0379959473264006 4570 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain.
SGTC_2485 5633444 17.78 µM -1.77480954023544 0.057347200347884 no 3183 0.0379646702788479 4589 5724239
SGTC_3149 9097855 49.47 µM -1.77578716943319 0.0572450042977786 no 3184 0.037884001640229 4604 25236625 YMR079W SEC14
SGTC_122 0236-0016 402.397 µM -1.78632837744326 0.0561521663050766 no 3185 0.0370230523942764 4603 6808838
SGTC_2373 9071805 200 µM -1.78891566823747 0.0558864647716497 no 3186 0.0368141990272118 4619 10149009
SGTC_2356 9061756 188.97 µM -1.79231338874808 0.0555390439458371 no 3187 0.0365413899005399 4640 20104043
SGTC_373 0844-0104 25.9 µM -1.79256825765224 0.0555130522024684 no 3188 0.0365209928821649 4634 5375804
SGTC_1658 st012944 20 µM -1.80053474375276 0.0547054538899524 no 3189 0.0358881213227685 4478 24207260
SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM -1.80115283808073 0.0546431852349297 no 3190 0.0358393967536157 4601 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis.
SGTC_1657 st012939 43.4 µM -1.81589745938097 0.0531743167039349 no 3191 0.0346930515611437 4630 24207257
SGTC_2636 apigenin dimethyl ether 100 µM -1.82145790248459 0.0526285786453153 no 3192 0.0342686401623479 4589 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_3337 9144342 33.5465 µM -1.8228018941466 0.0524973398533713 no 3193 0.0341667003794247 4635 17682949
SGTC_2761 levamisole 97.89 µM -1.8240158425832 0.0523790230033817 no 3194 0.0340748385902708 4631 26879 An alkaline phosphatase inhibitor.
SGTC_345 1362-0200 395 µM -1.82538670112547 0.0522456676282177 no 3195 0.0339713473701675 4630 1419823
SGTC_3310 9130229 44.1445 µM -1.82688419604145 0.052100301515428 no 3196 0.0338585914728207 4643 7761258
SGTC_95 0471-0001 561.058 µM -1.82690251519201 0.0520985252143608 no 3197 0.0338572140161703 4612 4015405
SGTC_3236 9132701 49.47 µM -1.82893269260911 0.0519019686655577 no 3198 0.033704845969866 4655 24282524
SGTC_50 0929-0078 56.389 µM -1.8317847077834 0.051626839805351 no 3199 0.0334917512247147 4502 1377751
SGTC_211 3455-0679 143.504 µM -1.83294459134387 0.0515152800961096 no 3200 0.033405405750197 4605 748649
SGTC_3151 9099821 49.47 µM -1.83476745731774 0.0513403410001215 no 3201 0.0332700761768489 4581 17174189
SGTC_1395 3486-0190 4.35 µM -1.8394766011796 0.0508905948079344 no 3202 0.0329225582032277 4624 6748079
SGTC_1192 1488-0095 21.4 µM -1.84684357193892 0.0501933107647547 no 3203 0.0323849074386317 4665 915875
SGTC_1172 0370-0043 85 µM -1.84992420740034 0.0499039960707875 no 3204 0.0321622371627262 4659 376585
SGTC_2551 apiole 73.87 µM -1.85189161921105 0.0497199256174273 no 3205 0.0320206938223584 4594 10659 A possible DNA adduct former.
SGTC_425 3825-7017 13.1 µM -1.85608164002495 0.0493297138836429 no 3206 0.0317209611399761 4626 3397440
SGTC_2037 5169046 200 µM -1.86375904101421 0.0486210741448487 no 3207 0.0311777750186195 4692 5718022
SGTC_2746 daunorubicin 9.88 µM -1.87066869026033 0.0479902795993324 no 3208 0.0306955085704823 4681 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_2589 lobaric acid 100 µM -1.87401236161141 0.0476873903465853 no 3209 0.0304643606623204 4580 73157 A novel microtubule depolymerizer.
SGTC_355 1311-2252 105 µM -1.87749432030251 0.0473736034398493 no 3210 0.0302251875288064 4612 5338538
SGTC_1277 0873-0036 22 µM -1.88495460448523 0.0467068681328993 no 3211 0.0297179834715464 4688 5965735
SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM -1.88648546200246 0.0465709887638406 no 3212 0.0296147828350481 4598 17037758
SGTC_2549 cedrol 20.94 µM -1.89004007007998 0.0462567040798188 no 3213 0.0293763006119213 4626 6708665 A sedative which affects the nervous system.
SGTC_1268 0828-0275 2.46 µM -1.89034944683931 0.0462294309440074 no 3214 0.029355619864636 4685 745337
SGTC_775 4577-0580 57.3 µM -1.90378417333293 0.0450574945655085 no 3215 0.0284691492889861 4656 2006902
SGTC_1909 st060837 51.5 µM -1.90421678686629 0.0450201579567688 no 3216 0.0284409781681338 4609 678937
SGTC_621 3584-0052 32.1 µM -1.92393857324122 0.0433443498887956 no 3217 0.0271811417531267 4694 2273927
SGTC_732 3970-1727 52.7 µM -1.92922929830417 0.0429034571100339 no 3218 0.0268512012392773 4697 1275699
SGTC_97 0535-0701 19.132 µM -1.93255253325303 0.0426283794743659 no 3219 0.0266456723041323 4580 2832013 YGL099W LSG1
SGTC_1322 1348-1070 12 µM -1.93261193426259 0.0426234756145122 no 3220 0.0266420105743855 4667 6758089
SGTC_210 3551-0445 56.827 µM -1.93978061961196 0.0420350045194009 no 3221 0.0262031784638492 4642 2865180 YOR207C RET1
SGTC_2372 9071633 200 µM -1.94046010965389 0.0419795686690848 no 3222 0.02616189877499 4697 21321366
SGTC_2220 6782180 200 µM -1.94350085670213 0.0417322154815569 no 3223 0.0259778359867761 4656 833803
SGTC_2143 5623677 140.463 µM -1.94404650170334 0.041687954503415 no 3224 0.0259449218575072 4657 5375313
SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM -1.94562315723447 0.0415602748811376 no 3225 0.0258500116151099 4612 6708739 YPR165W RHO1
SGTC_1444 4112-3581 28 µM -1.96560848816475 0.0399691360784316 no 3226 0.0246719264275024 4725 2877249
SGTC_3136 9095672 49.47 µM -1.96591729487612 0.0399449442835742 no 3227 0.0246540824660505 4557 17217380
SGTC_3085 9117376 49.47 µM -1.97395597102832 0.0393193733349405 no 3228 0.0241933747847325 4712 16480349
SGTC_1132 3456-3614 2.5 µM -1.97629713026177 0.0391386904015823 no 3229 0.0240605672240327 4640 3125502
SGTC_1679 SEC14.276 6.7 µM -1.97892918387862 0.0389363648375114 no 3230 0.0239119899672095 4627 1005053 YMR079W SEC14
SGTC_2141 5621638 7.665 µM -1.98536296592667 0.0384453849380921 no 3231 0.0235520515982651 4688 2856238
SGTC_3297 9117502 71.43 µM -1.99495620524601 0.0377226812898242 no 3232 0.0230238282915573 4697 7453720
SGTC_504 lovastatin 124 µM -1.99984670073109 0.0373585471694041 no 3233 0.0227584099927942 4675 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1
SGTC_342 k048-0088 23.3 µM -2.00263726485588 0.0371520585896051 no 3234 0.0226081184908397 4695 6820570
SGTC_2098 5376439 882.5 nM -2.00659137713235 0.036861070918943 no 3235 0.0223965951091215 4707 2844116
SGTC_915 methyl methanesulfonate (MMS) 110 mM -2.01219917456481 0.0364515848294182 no 3236 0.0220994727413475 4695 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks.
SGTC_3062 9077494 49.47 µM -2.01624671277188 0.0361583492529371 no 3237 0.0218870919932616 4633 16459633
SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM -2.02143350518409 0.0357854035577808 no 3238 0.0216174546253425 4676 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_2023 5144124 124 µM -2.02386339479502 0.0356117746864198 no 3239 0.0214921046085172 4667 2830192
SGTC_1216 1165-0504 9.65 µM -2.03044386673941 0.0351450289465043 no 3240 0.021155720764326 4717 6304004
SGTC_1261 0712-0010 12.7 µM -2.03444948054835 0.0348633808263131 no 3241 0.0209531486531564 4678 2840123
SGTC_470 aa-861 153 µM -2.0399187036791 0.0344818162713645 no 3242 0.0206792117657137 4655 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor.
SGTC_106 0092-0003 11.579 µM -2.04558975903844 0.0340898007681013 no 3243 0.0203983749416332 4657 1072148
SGTC_891 0929-0073 133 µM -2.04619827258693 0.034047955427461 no 3244 0.0203684336196765 4704 5603632
SGTC_1061 3448-9325 110 µM -2.05401556804335 0.0335141344415236 no 3245 0.0199870924800753 4675 723482
SGTC_804 1595-0054 20.9 µM -2.0798156254749 0.031801007528276 no 3246 0.0187712236706152 4697 761523 Stimulates phospholipase C.
SGTC_151 3013-0144 2.285 µM -2.08497204005142 0.031467445252038 no 3247 0.0185359192946172 4482 906558 YHR107C CDC12
SGTC_845 0330-0138 4.51 µM -2.08553174770865 0.0314314130911813 no 3248 0.0185105297264702 4681 9039800
SGTC_3289 9119912 71.43 µM -2.09041497241843 0.0311184917721387 no 3249 0.0182902695406273 4692 17014829
SGTC_781 4335-2806 94.4 µM -2.0971262888742 0.0306926340670244 no 3250 0.0179911986928589 4714 845254
SGTC_3104 9120930 49.47 µM -2.10136998741795 0.0304258545865033 no 3251 0.0178042502043307 4706 17014836
SGTC_603 3794-0023 45.9 µM -2.10776557180203 0.0300274287928199 no 3252 0.0175256361147205 4726 3802260
SGTC_3019 9081971 49.47 µM -2.10826044669431 0.0299967807358999 no 3253 0.0175042336290926 4700 16451803
SGTC_393 acivicin 6.25 µM -2.11903060131122 0.0293361748291948 no 3254 0.0170439404412206 4602 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1
SGTC_2880 9042983 58.44 µM -2.12746659657444 0.0288272159246002 no 3255 0.0166906669417332 4660 6464714
SGTC_1971 st069429 63.5 µM -2.13149840820242 0.0285865743236616 no 3256 0.016524051721033 4708 1246522 YGL099W LSG1
SGTC_82 0054-0107 293.755 µM -2.13534973014889 0.0283582680230419 no 3257 0.0163662268095629 4695 3104697
SGTC_2048 5246248 200 µM -2.13969415974141 0.0281025535850875 no 3258 0.0161897456738248 4731 677046
SGTC_1940 st075990 51.1 µM -2.13978432048847 0.0280972670992239 no 3259 0.0161861004651411 4710 1084979
SGTC_1025 k007-0731 70 µM -2.14360759700165 0.0278738539445369 no 3260 0.0160321707779482 4693 6256118
SGTC_3146 9095609 49.47 µM -2.14399021090742 0.0278515775878039 no 3261 0.0160168355751772 4712 17173999
SGTC_3311 9131146 2.8755 µM -2.15032297669201 0.0274850235726858 no 3262 0.0157648380837272 4692 4900406 YPR165W RHO1
SGTC_2225 6654152 15.4 µM -2.15865384007044 0.0270089496866529 no 3263 0.0154385162142713 4709 97582 YGR029W | YLR033W ERV1 | RSC58
SGTC_950 1165-0508 94.1 µM -2.16081117717368 0.0268867950158259 no 3264 0.0153549641601259 4696 6148369
SGTC_3176 9106582 49.47 µM -2.16145477324071 0.0268504421931607 no 3265 0.0153301134838602 4746 17018027
SGTC_3284 9108171 64.8615 µM -2.16478222583335 0.0266631486014636 no 3266 0.0152021833039591 4695 8687505
SGTC_1079 idarubicin 2.36 µM -2.1746625627407 0.0261134304556826 no 3267 0.0148277061474319 4737 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_602 3130-1533 38.1 µM -2.17468542099433 0.0261121697510511 no 3268 0.0148268490723528 4730 720941
SGTC_2076 5212012 200 µM -2.17933203785685 0.0258569489360897 no 3269 0.0146535054286283 4722 604802
SGTC_1829 berberine 14.4 µM -2.18509527440336 0.0255432997302088 no 3270 0.0144409308363809 4664 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_1582 3',3',6'-trihydroxyflavone 74 µM -2.18550064317537 0.025521359024479 no 3271 0.0144260794219395 4708 688803
SGTC_1323 1348-1351 11.2 µM -2.18564139659591 0.0255137443957751 no 3272 0.0144209257436156 4711 6989654
SGTC_101 0490-5701 117.494 µM -2.18827717341732 0.0253715023573409 no 3273 0.0143247092945675 4640 4661669
SGTC_1643 st009866 20.2 µM -2.1921019082553 0.0251662789489588 no 3274 0.0141860745012659 4722 3156273 YOR207C RET1
SGTC_485 niflumic acid 177 µM -2.19519320899379 0.0250014276016203 no 3275 0.0140748706059283 4741 4488 A COX2 inhibitor.
SGTC_3266 9136860 49.47 µM -2.19879397524009 0.0248105501111971 no 3276 0.0139462875480654 4501 4871271 YPR165W RHO1
SGTC_2256 7954252 200 µM -2.19956367667614 0.0247699070084867 no 3277 0.01391893333659 4731 2972920
SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM -2.21510514868511 0.0239611331508103 no 3278 0.0133764240649415 4716 2374 Ca(2+)-ATPase inhibitor.
SGTC_857 0438-0306 1.35 µM -2.21614346197207 0.0239078997708232 no 3279 0.0133408392518857 4746 4686136
SGTC_2615 purpurogallin-4-carboxylic acid 100 µM -2.22369253506734 0.0235238465046527 no 3280 0.0130845689126978 4687 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase.
SGTC_1937 st074714 47.2 µM -2.22667139485508 0.0233737339037048 no 3281 0.01298462177493 4694 17250970
SGTC_1369 1866-0067 208 µM -2.22832584305641 0.0232907106334081 no 3282 0.0129293971096078 4713 3531355
SGTC_2719 novobiocin 32.65 µM -2.23312303463424 0.0230513807435617 no 3283 0.0127704159891216 4741 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication.
SGTC_3218 9131285 49.47 µM -2.23971776395402 0.0227257557385226 no 3284 0.0125546257894386 4691 17156417
SGTC_1736 st036774 51 µM -2.24098514518266 0.0226636229880583 no 3285 0.0125135186242558 4738 1272247
SGTC_3260 9137109 49.47 µM -2.2440564333488 0.0225136482732154 no 3286 0.0124143852997999 4730 17478346
SGTC_2458 5808907 16.39 µM -2.25293305905557 0.0220848887930996 no 3287 0.012131685022379 4768 2731747
SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM -2.27377338411645 0.021105275356637 no 3288 0.0114898076588396 4714 115019
SGTC_1409 3909-8004 61.9 µM -2.27549632120307 0.0210259589721552 no 3289 0.0114380865574663 4763 2119279
SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM -2.27599873609802 0.0210028775738676 no 3290 0.0114230426308 4757 688788
SGTC_2649 anisomycin 9.56 µM -2.27785189850172 0.0209179269252902 no 3291 0.0113677014959303 4761 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_768 0384-0033 77.3 µM -2.28348624976185 0.0206614274632004 no 3292 0.0112008709496446 4716 3965305 YMR134W ERG29
SGTC_1235 benzylparaben 21.5 µM -2.29987773026001 0.0199303178605431 no 3293 0.0107275740482613 4761 7180
SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM -2.31952931024213 0.0190828430285732 no 3294 0.010183176885478 4708 6708514
SGTC_2381 9035592 200 µM -2.33935814459302 0.0182589780695492 no 3295 0.00965845290297629 4744 4749657
SGTC_942 3253-1115 227 µM -2.34430538389033 0.018058215164172 no 3296 0.00953127803965203 4750 46497897
SGTC_2492 derrusnin 100 µM -2.36732422808088 0.0171486620378172 no 3297 0.00895861431020819 4762 1715307 Part of coumarin class of compounds.
SGTC_2669 eugenol 100 µM -2.36880976657265 0.0170913326081575 no 3298 0.00892271479308506 4780 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism.
SGTC_2812 7970281 58.44 µM -2.3750797937491 0.016851162990163 no 3299 0.0087725784263747 4742 2233435
SGTC_1320 1313-0481 95.3 µM -2.3771393261935 0.0167729061878996 no 3300 0.00872374826247095 4725 6813365 YLR208W SEC13
SGTC_371 0195-0006 7.36 µM -2.38128964974913 0.0166161489212403 no 3301 0.00862607033643667 4644 3928593
SGTC_909 3448-9333 149 µM -2.40875277757411 0.0156101383831278 no 3302 0.00800356850885079 4720 3344074
SGTC_2701 st077767 14.721 µM -2.41404324830097 0.0154224664051154 no 3303 0.00788829479755026 4735 5721188
SGTC_1453 4237-0541 195 µM -2.41689784947589 0.0153220104250444 no 3304 0.00782670467307244 4752 739892
SGTC_1134 3477-0009 42.5 µM -2.41955341486521 0.0152290637282364 no 3305 0.0077697891480806 4726 3973534
SGTC_3211 9128781 49.47 µM -2.42275267469532 0.0151177309300309 no 3306 0.00770170480567507 4672 17194361
SGTC_53 0973-0023 39.979 µM -2.45299787956007 0.0140993245717842 no 3307 0.00708355868865963 4715 674768
SGTC_2043 5101342 149 µM -2.4931086388278 0.012840308830419 no 3308 0.00633150475068903 4762 678451
SGTC_1222 0366-0074 1.18 µM -2.50388628903486 0.0125190589811806 no 3309 0.0061418753026073 4762 286520
SGTC_2806 7952793 58.44 µM -2.50628643913017 0.0124484725374762 no 3310 0.0061003368136824 4743 2972490
SGTC_778 3456-2434 196 µM -2.50873969049566 0.0123766808633987 no 3311 0.00605813676311385 4705 5539063
SGTC_2138 5575593 77.673 µM -2.53398524091178 0.0116584901814619 no 3312 0.00563867407412019 4777 762213
SGTC_720 r052-1644 49.9 µM -2.538597179487 0.0115312724040752 no 3313 0.00556489439869465 4764 1422863 YOR257W CDC31
SGTC_2526 patulin 37.61 µM -2.53959336120063 0.0115039521592057 no 3314 0.00554907101256603 4751 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.
SGTC_19 0279-0214 38.434 µM -2.54174951284542 0.0114450122450354 no 3315 0.00551495942582337 4794 3566274 YBR002C RER2
SGTC_475 α-linolenic acid 10 µM -2.55036488132298 0.0112121157072963 no 3316 0.0053805113977058 4755 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_472 calcifediol 10 µM -2.55494544063787 0.011089976763793 no 3317 0.00531022217417674 4786 5283731 A vitamin D metabolite.
SGTC_1 0258-0098 57.368 µM -2.56677160028232 0.0107799728508741 no 3318 0.00513251005199691 4701 6790032 YDR047W HEM12
SGTC_763 3453-1109 128 µM -2.57580697665928 0.010548235183145 no 3319 0.00500032285036996 4772 1560353
SGTC_2496 diffractaic acid 79.83 µM -2.58961144448886 0.0102025625769625 no 3320 0.00480421581070433 4748 94870 An apoptosis inducer which activates caspases.
SGTC_173 1273-0061 2.693 µM -2.59928529695353 0.00996625027974949 no 3321 0.00467090483761475 4734 2847414 YPL266W DIM1
SGTC_49 0717-0965 32.132 µM -2.61602149420713 0.00956869076894384 no 3322 0.00444804786410031 4777 5889349 YGL099W LSG1
SGTC_9 0092-0002 10.449 µM -2.66074617750104 0.00857355113702421 no 3323 0.00389838540025866 4774 759368
SGTC_2813 7971799 71.43 µM -2.67672576081906 0.00824068204737596 no 3324 0.00371727298655553 4757 2234054
SGTC_1552 6-methylflavone 10.6 µM -2.67740075469675 0.0082268747011601 no 3325 0.00370979150110754 4773 689013
SGTC_85 0868-0259 160.055 µM -2.71319563952439 0.0075231831731698 no 3326 0.00333188758915899 4770 83173
SGTC_2566 crystal violet carbinol 226 nM -2.74595229283474 0.0069262470856169 no 3327 0.00301677683296741 4711 68050 Cationic dye that binds acidic phospholipids including cardiolipin.
SGTC_304 1310-0298 97 µM -2.76177051100738 0.00665325999186007 no 3328 0.00287444354609778 4613 1550234
SGTC_1987 st072290 61.9 µM -2.77666171894535 0.00640500732981842 no 3329 0.00274601529640556 4788 54697379
SGTC_3060 1327-0027 12.5 µM -2.77944827344927 0.00635947381982231 no 3330 0.00272256624538079 4738 16000455 YPR107C YTH1
SGTC_23 0213-0011 39.996 µM -2.78344004434666 0.00629474574885217 no 3331 0.0026892901134852 4772 627608
SGTC_1282 0886-0010 32.4 µM -2.80779964996186 0.00591223818839881 no 3332 0.00249406245969378 4789 2836211 YNL267W PIK1
SGTC_824 1304-0008 100 µM -2.83933702902946 0.0054477128905858 no 3333 0.00226036904455082 4784 768245
SGTC_29 0299-0004 12.984 µM -2.86638535132342 0.00507545403630898 no 3334 0.00207594257556194 4760 16871 A napthoquinone isolated from Swertia calycina.
SGTC_2877 9040724 71.43 µM -2.88396312914308 0.00484584591338817 no 3335 0.00196352364796702 4773 6463895
SGTC_3189 9110682 49.47 µM -2.89601298151785 0.00469384121065711 no 3336 0.00188968382790496 4782 17122418
SGTC_2689 tacrolimus 100 µM -2.92294999209165 0.00436932224804569 no 3337 0.00173366099525374 4779 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12).
SGTC_3077 9117319 49.47 µM -2.92885340205243 0.00430093882567569 no 3338 0.0017010741887554 4770 17154678
SGTC_734 2023-0417 80 µM -2.94801389243835 0.00408553288177298 no 3339 0.00159911345869393 4785 3935732
SGTC_3294 9122953 26.2835 µM -2.96520316335427 0.00390055912659819 no 3340 0.00151241548930712 4776 16459826
SGTC_3259 9138485 49.47 µM -2.99898761416828 0.00355872549469403 no 3341 0.00135439159177441 4775 17646153
SGTC_2837 9008476 45.46 µM -3.06114906152647 0.00299929913134466 no 3342 0.00110244647822396 4776 2992805
SGTC_182 3448-4371 550.524 µM -3.06320252084256 0.00298225211984502 no 3343 0.00109490902940579 4769 3491403
SGTC_2572 astragaloside iv 100 µM -3.11232380551843 0.00259963693631432 no 3344 0.000928103895881948 4781 45006101 An anti-inflammatory agent.
SGTC_944 3370-0224 231 µM -3.13719639081978 0.00242333266220466 no 3345 0.000852859155223424 4780 4580514
SGTC_1880 MG-132 525 µM -3.19666728726024 0.00204481828687709 no 3346 0.000695125923237117 4781 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1
SGTC_2125 5246583 200 µM -3.28992057711067 0.00155821829834192 no 3347 0.000501078326689086 4789 835267
SGTC_2127 5253358 187.912 µM -3.40874035146103 0.00109153699839156 no 3348 0.000326317825210285 4791 20612
SGTC_1813 st051246 8.6015 µM -3.45853004357492 0.000937249296254477 yes 3349 0.000271565846830067 4803 5291959
SGTC_2354 9060492 162 µM -3.67575193648553 0.000471378814992322 yes 3350 0.00011857493772881 4788 6471895
SGTC_3105 9121040 49.47 µM -3.67881223486327 0.00046671461478033 yes 3351 0.000117161348130354 4801 41448907
SGTC_2355 9061122 103.12 µM -4.00170768296021 0.000156886004998114 yes 3352 3.14434811196741e-05 4793 5302957
SGTC_2823 7987624 58.44 µM -4.06374668193705 0.000126056230557054 yes 3353 2.41456172531816e-05 4790 2239440
SGTC_2822 7994718 71.43 µM -4.24180970251169 6.61543815670434e-05 yes 3354 1.10862328869352e-05 4806 1018011
SGTC_431 k089-0097 107 µM -5.00216544358242 3.18147642255692e-06 yes 3355 2.83449533023439e-07 4751 5499420
SGTC_3219 9131112 49.47 µM -8.31490265635119 2.57304204471124e-14 yes 3356 4.5913805399989e-17 4809 17612988 YMR079W SEC14