SGTCid condition conc unit PUS6|YGR169C.score PUS6|YGR169C.strain.pval PUS6|YGR169C.strain.significant PUS6|YGR169C.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene
SGTC_2641 levomentholum 100 µM 6.31056342922841 4.47731924549225e-14 yes 1 1.39010718382893e-10 2 16666
SGTC_358 0075-0058 9.45 µM 4.49719936617308 5.06792558342987e-08 yes 2 3.44272094128802e-06 43 1069125
SGTC_2337 9009472 200 µM 4.2606631804651 2.25251867209978e-07 yes 3 1.01910602131142e-05 23 5742383
SGTC_2336 9001819 198.65 µM 3.80189796305215 3.28596580969557e-06 yes 4 7.17959331551956e-05 61 2989602
SGTC_987 1497-1013 404 µM 3.57165924745071 1.13511737596467e-05 yes 5 0.000177363376179158 18 1676435
SGTC_2297 7971671 152.32 µM 3.53664930053241 1.36218625374847e-05 yes 6 0.000202618690688523 42 909016
SGTC_2322 7413319 38.22 µM 3.44653242851006 2.16199589828077e-05 yes 7 0.000283915205791051 192 1840400
SGTC_1698 5-fluorocytosine 1.055 µM 3.33087044895545 3.85058196659685e-05 yes 8 0.000432874418860091 18 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_1748 st037455 53.6035 µM 3.26755991393833 5.24202986966848e-05 yes 9 0.000542394513996224 63 580690
SGTC_535 2293-4129 48.2 µM 3.26265444368134 5.36765487523347e-05 yes 10 0.000551870065439911 102 396118 YIL048W NEO1
SGTC_2327 6189656 200 µM 3.24873036489494 5.73989349630317e-05 yes 11 0.000579606514661274 49 5349088
SGTC_3291 9121177 71.43 µM 3.15713342815018 8.86553697357022e-05 yes 12 0.000796642115622985 35 17015612
SGTC_431 k089-0097 107 µM 3.14320581311942 9.46225143331051e-05 yes 13 0.000835541487793436 88 5499420
SGTC_2434 5670830 169.91 µM 3.11666744650588 0.000107051607560744 yes 14 0.000914538867796147 64 1549830
SGTC_1735 st034310 56.75 µM 3.09016956260072 0.000120979206318116 yes 15 0.00100021128372448 63 871153
SGTC_1498 4478-3555 97.6 µM 3.02838315518189 0.000160331466831978 yes 16 0.0012293306804808 22 3437919
SGTC_2697 mebhydrolin 72.4 µM 2.95434788402744 0.000223214818561704 yes 17 0.00156665289473564 133 22530 H1 Histamine receptor antagonist. YIL048W NEO1
SGTC_1810 st050138 53 µM 2.91188689931325 0.000268992907341107 yes 18 0.00179626344747772 38 3444541
SGTC_851 0394-0702 453 µM 2.90440363242264 0.000277916061393093 yes 19 0.00183976728481505 51 762646
SGTC_397 arbidol 50 µM 2.89311890124201 0.000291894797605033 yes 20 0.00190718434962089 70 131410 A RNA synthesis inhibitor.
SGTC_2481 5478948 45.16 µM 2.77466366440532 0.000483736803149618 yes 21 0.0027629411144169 112 77792
SGTC_1315 1237-0019 3.69 µM 2.75389027961283 0.000527554631945971 yes 22 0.00294457538340305 56 825140
SGTC_532 1548-0774 215 µM 2.74677270863029 0.000543393521604377 yes 23 0.00300924137629505 81 5932993
SGTC_3009 9080819 71.4286 µM 2.68612220884282 0.000697320150535387 yes 24 0.0036143321961171 95 17027216
SGTC_1073 triclabendazole 3.09 µM 2.68522108013671 0.000699883896614846 yes 25 0.00362409220862013 121 50248 An antihelmetic and likely tubulin inhibitor.
SGTC_1689 st020265 53.493 µM 2.67484993850987 0.000730022395481065 yes 26 0.00373813530254663 71 5758320 YPR016C TIF6
SGTC_2462 5162487 171.77 µM 2.65225791489187 0.000799859048474265 yes 27 0.00399777204127388 86 2259986
SGTC_2568 diosmetin 100 µM 2.63237140230873 0.000866368177768887 yes 28 0.00423955577767757 103 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.
SGTC_874 0599-0792 117 µM 2.60767343183595 0.000956040096797533 yes 29 0.00455799388498527 116 765305
SGTC_2347 9049783 174.81 µM 2.58391429922368 0.00105027186301677 no 30 0.00488430321434561 129 6467988 YPL169C MEX67
SGTC_383 2324-0395 7.37 µM 2.5806798612977 0.00106373904446006 no 31 0.00493029879302917 144 3146421
SGTC_2309 7664088 163.95 µM 2.57573757424227 0.00108462324863999 no 32 0.00500132653891055 151 704922
SGTC_2130 NSC 7 2.4545 µM 2.56538856236118 0.00112957689576525 no 33 0.00515301602420189 142 21448
SGTC_2820 7989630 71.43 µM 2.44566774492273 0.00178896796822543 no 34 0.00722920864870496 103 2984098
SGTC_1715 st032160 10.2275 µM 2.42586771821911 0.00192689881110875 no 35 0.00763591783018453 146 5289825
SGTC_2326 6164455 177.58 µM 2.42267823999857 0.00194999968006391 no 36 0.0077032828851121 118 2888790
SGTC_2586 curcumin 80 µM 2.40388612978997 0.0020912897501491 no 37 0.00811091267478128 205 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40
SGTC_3019 9081971 49.47 µM 2.40071652383979 0.00211601594022588 no 38 0.00818150350021946 105 16451803
SGTC_1948 st076329 66.6 µM 2.38516173722819 0.00224124591504667 no 39 0.00853580702530389 139 24208413
SGTC_193 1273-0060 1.558 µM 2.379919143401 0.00228494303952644 no 40 0.00865821860946864 80 2847393 YHR072W ERG7
SGTC_537 1334-0398 209 µM 2.36883916857277 0.00237984347665354 no 41 0.00892200553833569 148 5846986
SGTC_2487 5918373 44.05 µM 2.36819844183199 0.00238543891126261 no 42 0.00893747277378981 129 2876279
SGTC_3153 9100258 49.47 µM 2.36103251977049 0.00244883472922983 no 43 0.00911206622340166 150 25236848
SGTC_2245 6637752 200 µM 2.32630312341082 0.00277820111607536 no 44 0.01000119276224 92 681890
SGTC_2114 5491910 81.25 µM 2.31167874668128 0.00292847720251689 no 45 0.0103976967321494 117 2849228
SGTC_813 k007-0158 173 µM 2.30861338295097 0.00296089000606515 no 46 0.0104825223214472 187 6523916
SGTC_2096 5468907 200 µM 2.30825845938509 0.00296466373615667 no 47 0.0104923827117014 121 759785
SGTC_2693 st077581 40.7 µM 2.30066275137326 0.00304647114973203 no 48 0.0107053505413204 197 25238761
SGTC_530 4358-1714 28 µM 2.29785016970499 0.00307727539605952 no 49 0.0107851591061767 189 1564641
SGTC_374 0880-0231 82.3 µM 2.27797927699725 0.00330301857878286 no 50 0.0113639061533011 159 6833587
SGTC_1235 benzylparaben 21.5 µM 2.27393805670108 0.00335071131347632 no 51 0.0114848555638374 129 7180
SGTC_1859 st055998 20 µM 2.26198150433235 0.00349546373033044 no 52 0.0118492730272798 154 676301
SGTC_718 1130-0073 349 µM 2.26033783468118 0.00351579594547844 no 53 0.0119001457569736 153 6740020
SGTC_476 mead acid 10 µM 2.22950880652914 0.00391734821041598 no 54 0.0128900350080311 84 5312531 An omega 9 fatty acid.
SGTC_1243 0416-0003 5.65 µM 2.22488281168169 0.00398102402197063 no 55 0.0130445530924954 198 2141977
SGTC_411 enrofloxacin 100 µM 2.20691382876966 0.00423724665177165 no 56 0.0136600400574704 138 71188 A bacterial gyrase inhibitor.
SGTC_189 3970-0742 2.116 µM 2.19968196793005 0.00434446149286227 no 57 0.0139147335192846 108 2891807
SGTC_1411 3909-8223 150 µM 2.1924096417167 0.00445471472699971 no 58 0.0141749705300273 139 X1411
SGTC_1525 8-methoxypsoralen 92.5 µM 2.1903267965783 0.0044867490868654 no 59 0.0142502723957094 190 4114 Related to psoralen; DNA damaging agent.
SGTC_1501 4491-0275 38.4 µM 2.18822642121872 0.0045192612351191 no 60 0.0143265567207951 137 5104718
SGTC_1211 1056-0033 32.3 µM 2.18289198747358 0.00460278155528232 no 61 0.0145218826207446 140 6741922
SGTC_2800 7887935 81.82 µM 2.17294381699158 0.0047622259826569 no 62 0.0148922730450948 184 2961002
SGTC_2345 9052315 157.45 µM 2.16754505997859 0.00485080064671072 no 63 0.0150966588757342 192 6469265
SGTC_1813 st051246 8.6015 µM 2.16558317335104 0.00488335029116071 no 64 0.0151715266747006 131 5291959
SGTC_1784 st039334 36.3 µM 2.16487425968645 0.00489515966115677 no 65 0.0151986579625484 172 3496984
SGTC_457 grayanotoxin iii 135 µM 2.1259106257506 0.00558467417201688 no 66 0.0167553509854493 287 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity.
SGTC_499 genistein 192 µM 2.12078196987507 0.00568157874691062 no 67 0.016970077341115 95 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger.
SGTC_1853 st056710 91.2 µM 2.10607597427011 0.00596777227359153 no 68 0.0175988767165288 189 269167
SGTC_617 3770-0098 35 µM 2.10048300752433 0.0060799277588728 no 69 0.0178431869264636 170 5962639
SGTC_1976 st070609 63.5 µM 2.09471699655126 0.00619750485641383 no 70 0.0180980787091961 168 682556
SGTC_2458 5808907 16.39 µM 2.0930780272036 0.00623129127809528 no 71 0.0181710949086739 144 2731747
SGTC_1207 2099-0101 141 µM 2.09214323474862 0.00625063445320369 no 72 0.0182128523008926 196 5837381
SGTC_1716 st033144 30.6155 µM 2.09092278251679 0.0062759686529717 no 73 0.0182674932324432 191 674617
SGTC_3262 9137218 49.47 µM 2.08975774586508 0.00630023730648598 no 74 0.0183197833958659 82 17650664
SGTC_378 3970-0959 8.33 µM 2.08973045091195 0.00630080687705272 no 75 0.0183210099982854 180 6615653
SGTC_254 nsc-64875 3.808 µM 2.08520610820985 0.0063958498125505 no 76 0.0185252978440026 170 56993
SGTC_483 fpl-64176 144 µM 2.08408998995601 0.0064194903381142 no 77 0.0185759912070534 119 3423
SGTC_3081 9117243 49.47 µM 2.06731575931117 0.00678421493637588 no 78 0.0193522051181006 183 45595589
SGTC_288 1315-0019 35.1 µM 2.06518944568344 0.00683173115366193 no 79 0.0194525393811343 210 6811474
SGTC_181 1447-1644 8.07 µM 2.06464995088499 0.0068438337703261 no 80 0.0194780666684138 216 534600
SGTC_1422 4031-0024 15.5 µM 2.06231973939642 0.00689632577725442 no 81 0.0195886524651683 178 782427
SGTC_1257 0669-0121 16 µM 2.06032757342077 0.00694148430808106 no 82 0.0196836178211884 231 4307855
SGTC_910 3454-3003 490 µM 2.06005706027234 0.0069476364048655 no 83 0.0196965431129098 221 820824
SGTC_526 4469-0568 170 µM 2.04656245117641 0.00726070967932094 no 84 0.0203505323871015 225 2901964
SGTC_1262 0737-0114 49.6 µM 2.04318479973498 0.00734099128321538 no 85 0.0205170739348386 239 765919
SGTC_557 1315-0110 16.2 µM 2.03042183233129 0.00765145548055673 no 86 0.0211568396552245 214 6833801
SGTC_940 3232-1287 54.8 µM 2.01434385095989 0.00805897220752745 no 87 0.0219867225229801 219 1585493 YIL048W NEO1
SGTC_1811 st050069 61.5 µM 2.00983813351021 0.00817654508461398 no 88 0.0222241616726352 143 3877702
SGTC_2007 4011539 71.82 µM 2.00328788055609 0.00835015584786225 no 89 0.022573198791124 246 45595301
SGTC_2287 7945887 168.79 µM 2.00020957951753 0.00843285652420085 no 90 0.0227388189186943 190 1245853
SGTC_3323 9138564 53.9225 µM 1.98665902058635 0.00880550861157371 no 91 0.0234800979676801 246 43912313 YNL103W MET4
SGTC_996 3970-0799 1.8 µM 1.98511061286454 0.00884899675195173 no 92 0.0235660831440732 367 6615648 YGL040C HEM2
SGTC_2109 5483026 200 µM 1.96812562205823 0.00933852839160301 no 93 0.0245267927244994 262 759335
SGTC_907 3448-6986 75.5 µM 1.96305939041804 0.00948905934694884 no 94 0.0248196367505288 262 590582
SGTC_2982 9019404 25.97 µM 1.95995101573286 0.00958246382996675 no 95 0.0250007579724749 221 22333232
SGTC_2103 5378138 10 µM 1.93428709066921 0.0103848431663017 no 96 0.0265389197803616 249 244142
SGTC_1309 pyrazolanthrone 13.4 µM 1.9310802945919 0.010489108753697 no 97 0.0267365617425161 256 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14
SGTC_2986 9022445 71.43 µM 1.91387691770468 0.0110641730960562 no 98 0.0278179421828538 249 6459286
SGTC_1490 4089-0339 670 nM 1.91282415373237 0.0111002380243523 no 99 0.0278852839592278 165 742542
SGTC_384 k007-0144 5.16 µM 1.9015603914583 0.0114925483310102 no 100 0.0286143251253315 311 6824886
SGTC_1245 0418-0076 17.2 µM 1.89544130122314 0.0117106791193208 no 101 0.0290169806859281 264 6790114
SGTC_1726 st035556 14.5795 µM 1.89258972017059 0.0118135526984326 no 102 0.0292062259449777 298 5919439
SGTC_2563 tomatine 8.54 µM 1.86802255505479 0.0127327847100294 no 103 0.0308794635603748 330 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties.
SGTC_1499 4480-0877 67.3 µM 1.86707570736906 0.0127694185497798 no 104 0.030945508137334 189 2861909
SGTC_3330 9141424 71.43 µM 1.86354371615317 0.0129068780584114 no 105 0.0311929039835008 282 27261020
SGTC_2123 5259487 200 µM 1.86265530533035 0.0129416543533388 no 106 0.0312553889460712 264 2173474
SGTC_1630 st005209 31.3 µM 1.85737699417394 0.0131499458062745 no 107 0.031628768604211 307 3367314
SGTC_988 1497-1057 103 µM 1.84803533070434 0.0135256894661625 no 108 0.0322986159648664 276 3533044
SGTC_2739 tacrine 100.86 µM 1.84596180569405 0.0136103372038726 no 109 0.032448875703094 235 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders.
SGTC_1138 3761-0006 1.03 µM 1.83985964451871 0.0138621038255942 no 110 0.0328944230381565 213 12061087
SGTC_2275 7947463 200 µM 1.82412614292337 0.014529848339687 no 111 0.0340665020275717 244 1225414
SGTC_159 3970-0959 50 µM 1.8186168760344 0.0147701226406003 no 112 0.0344849506649181 505 6615653
SGTC_1035 k081-0041 55.2 µM 1.812181332367 0.0150551147754702 no 113 0.0349790912574998 304 731709
SGTC_417 st075190 100 µM 1.81161291659029 0.0150805121825037 no 114 0.0350230138601739 285 222757
SGTC_2219 9098279 200 µM 1.81041464382461 0.015134172895833 no 115 0.0351157550384563 252 902349
SGTC_1270 0831-1170 17.3 µM 1.81028521516056 0.0151399787391752 no 116 0.0351257843093561 283 6764716
SGTC_3352 9151559 45.5865 µM 1.80861185842681 0.0152152137798111 no 117 0.0352556624507167 266 17159339
SGTC_447 ml7 120 µM 1.80852211771246 0.0152192576294796 no 118 0.0352626388209192 270 4216 Selective myosin light chain kinase inhibitor.
SGTC_12 0849-0099 9.267 µM 1.80636836395664 0.0153165863047834 no 119 0.0354304098767875 258 6071388
SGTC_2877 9040724 71.43 µM 1.80396523162623 0.0154258149495319 no 120 0.035618378815471 240 6463895
SGTC_1887 st057648 70.8 µM 1.7946499996683 0.0158555596243956 no 121 0.0363547407767145 269 688672
SGTC_1708 st033234 31.827 µM 1.79410509811422 0.0158810126122377 no 122 0.0363981977463147 300 674664
SGTC_2490 carminic acid 95.39 µM 1.79339771230098 0.0159141076868677 no 123 0.036454676565318 198 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_212 3807-4682 38.772 µM 1.7895089738051 0.0160971004103448 no 124 0.0367664417865828 417 3125501 YBL034C STU1
SGTC_1213 1315-0166 115 µM 1.78279552709425 0.0164172601784396 no 125 0.0373097970764246 251 768401
SGTC_2645 abamectin 100 µM 1.78118841590332 0.0164947060422076 no 126 0.0374408377240949 309 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels.
SGTC_846 0335-0850 148 µM 1.76334689850344 0.0173756963923811 no 127 0.0389209999844688 261 6819598
SGTC_2660 2',4'-dihydroxychalcone 17.14 µM 1.76061409036067 0.0175141263737457 no 128 0.039151871067713 275 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_857 0438-0306 1.35 µM 1.75379157103754 0.0178638353947509 no 129 0.0397331139472827 291 4686136
SGTC_112 phenothiazine 287.218 µM 1.75142579661232 0.0179864830707335 no 130 0.0399362963376655 280 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.
SGTC_39 0986-0283 58.349 µM 1.74165427027667 0.0185006989466601 no 131 0.0407844794438208 366 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2
SGTC_725 1497-0963 19 µM 1.7367090837623 0.0187656701977772 no 132 0.0412192667839102 288 3549977
SGTC_2302 7771753 200 µM 1.73161071607071 0.019042223283076 no 133 0.041671448474137 367 2203047
SGTC_3132 9126706 49.47 µM 1.72248583267063 0.019545843587852 no 134 0.042490773510267 301 850858
SGTC_1179 1021-1431 9.29 µM 1.71769269737381 0.0198148878192788 no 135 0.0429263410321225 399 2840958
SGTC_804 1595-0054 20.9 µM 1.70582498370828 0.0204945927955975 no 136 0.044020335016137 311 761523 Stimulates phospholipase C.
SGTC_1414 3917-0015 5.4 µM 1.70330214391101 0.0206416031070033 no 137 0.0442557698003475 267 6618702
SGTC_990 3985-0011 41.3 µM 1.69181704848191 0.0213221975983189 no 138 0.0453404309813318 287 5399565 YGL099W LSG1
SGTC_1346 1488-2224 62.4 µM 1.68404601228481 0.0217933860278026 no 139 0.0460863883761477 310 3722427
SGTC_2395 5646831 180.19 µM 1.67879130189858 0.0221169594899666 no 140 0.0465963621948339 348 6808628
SGTC_937 3122-0005 46.7 µM 1.67378335641366 0.0224291020469603 no 141 0.0470865922495371 352 759535
SGTC_512 prima-1 270 µM 1.67138938362761 0.0225796247236902 no 142 0.0473223957497399 338 322968 A re-activator of the apoptotic function of mutant p53.
SGTC_687 k029-0044 34.9 µM 1.67097610677425 0.0226056957985234 no 143 0.0473631986560155 334 5829338
SGTC_2975 9084847 53.72 µM 1.66915878574054 0.0227206406612825 no 144 0.0475429577902526 358 27211724
SGTC_46 0329-0187a 2.197 µM 1.66696121794371 0.0228602935795016 no 145 0.0477610583460282 453 46494817
SGTC_659 k018-0002 107 µM 1.66586188586897 0.0229304258190309 no 146 0.0478704632697632 342 6797879 YHR007C ERG11
SGTC_2635 hydroquinidine 100 µM 1.65625417699694 0.0235511011780987 no 147 0.0488351779634581 331 442912 An experimental heart treatment.
SGTC_306 1672-3436 11.6 µM 1.6549184795606 0.0236384984131396 no 148 0.0489705175951804 341 6797378
SGTC_2229 7354935 190 µM 1.65383352735689 0.0237096895196374 no 149 0.0490806708679447 258 318112
SGTC_2107 5363541 170.161 µM 1.64786410040493 0.0241046166117134 no 150 0.0496902808256891 343 244052
SGTC_1526 st051518 75 µM 1.64246552154527 0.0244665220514906 no 151 0.050246782920697 314 673993
SGTC_2564 betulinic acid 100 µM 1.62902597821622 0.0253873248489619 no 152 0.0516537598126603 411 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14
SGTC_644 1498-1197 63.3 µM 1.62650857309825 0.0255629920609756 no 153 0.0519207555479122 379 6741615
SGTC_1894 3',6'-dihydroxyflavone 78.7 µM 1.6261440526196 0.0255885128485933 no 154 0.0519595072845276 344 688662
SGTC_2022 5136654 200 µM 1.62076938517288 0.0259672864582339 no 155 0.0525335532986581 369 1713771
SGTC_1022 4477-0945 21.3 µM 1.6190089756338 0.0260923645516338 no 156 0.0527226659642558 377 4648966
SGTC_2331 7980721 200 µM 1.61877434872338 0.0261090729162786 no 157 0.0527479115924752 371 2981221
SGTC_3142 9086498 49.47 µM 1.61630070820421 0.0262857720678432 no 158 0.0530146568976203 335 25236367
SGTC_155 k072-0202 43.6 µM 1.60119465497329 0.0273866623321663 no 159 0.0546669061686058 327 5857737
SGTC_3339 9145883 14.936 µM 1.59685448571883 0.0277099827002281 no 160 0.0551490736500274 344 2030670
SGTC_3195 9113082 49.47 µM 1.58940037741567 0.028272696556985 no 161 0.0559850147286464 326 17018038
SGTC_522 1273-0010 11.6 µM 1.58549306627169 0.0285714404799105 no 162 0.0564271755281972 360 5705015
SGTC_1701 st028638 40.4 µM 1.58091232696804 0.0289250119443341 no 163 0.0569490426913349 368 3490878
SGTC_2048 5246248 200 µM 1.57788825016321 0.0291604170875974 no 164 0.057295642399715 318 677046
SGTC_716 1683-5115 658 µM 1.5772961657746 0.0292066929034559 no 165 0.057363697118817 436 723597
SGTC_2965 9082772 38.63 µM 1.56913571034019 0.029850731121821 no 166 0.0583081602255865 405 16459634
SGTC_2191 5911152 200 µM 1.56087692432764 0.030514479860368 no 167 0.0592763964419925 367 2875902
SGTC_1389 3405-0187 19 µM 1.55249405706224 0.0312006565895626 no 168 0.0602720268041731 375 799890
SGTC_3061 glucosamine 200 µM 1.54969148274244 0.0314328878613258 no 169 0.0606077917033334 343 91431 and experimental redox chemotherapeutic
SGTC_3038 9091290 49.47 µM 1.54758881517979 0.0316080591188547 no 170 0.0608606630010035 394 25236843
SGTC_3139 9095020 49.47 µM 1.54659988932962 0.031690724125714 no 171 0.0609798782185483 275 25236292
SGTC_559 1550-0661 158 µM 1.54483710789165 0.0318385192679642 no 172 0.0611928345251306 378 5830875
SGTC_1225 1216-0074 20.6 µM 1.54166136141157 0.0321062169763444 no 173 0.0615779529726192 377 4241466
SGTC_1692 fluoroquinolonic acid 71 µM 1.54139860771901 0.0321284486340871 no 174 0.0616099013434167 351 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2
SGTC_514 4466-0038 2.65 nM 1.54062494382537 0.0321939823468788 no 175 0.0617040467426795 526 5722064
SGTC_3045 9092950 49.47 µM 1.54035067775941 0.0322172407104245 no 176 0.0617374485096666 424 44120432
SGTC_3001 9076041 71.4286 µM 1.5359205748333 0.0325948482806966 no 177 0.0622789306466821 385 16004211
SGTC_973 1325-0077 65.9 µM 1.52906179658962 0.0331866628543661 no 178 0.0631245624964962 432 2835149
SGTC_3264 9137442 49.47 µM 1.52635459988285 0.0334226787754867 no 179 0.0634607888679207 360 17015726
SGTC_746 1095-0025 46.6 µM 1.52335869493326 0.033685473689996 no 180 0.0638344949767265 425 6749286
SGTC_3064 1327-0027 10 µM 1.52159139213058 0.033841293820769 no 181 0.0640557478636996 245 16000455 YPR107C YTH1
SGTC_3315 9136395 68.55 µM 1.51865965248594 0.0341010877745196 no 182 0.0644240937464905 422 16876844
SGTC_2271 7849410 118.62 µM 1.51750693488586 0.0342036831179039 no 183 0.0645693719660872 385 972430
SGTC_984 1492-0255 2.91 µM 1.50969011969098 0.0349061162315276 no 184 0.0655612567835731 392 1585198
SGTC_497 capsazepine 133 µM 1.5087790915939 0.0349887479021786 no 185 0.0656776228191756 386 2733484 A calcium channel blocker.
SGTC_183 3914-0051 30.55 µM 1.50694381209259 0.0351556981092457 no 186 0.065912530040248 411 1596232
SGTC_2905 7799065 20.05 µM 1.50467187261744 0.0353632748064756 no 187 0.0662042289823988 368 1296806
SGTC_1673 st016611 27.3 µM 1.50201133465486 0.0356076326110681 no 188 0.0665470907900069 446 5226799
SGTC_2987 9018338 71.43 µM 1.50075086537426 0.0357238830053543 no 189 0.0667100057458901 427 5055682
SGTC_2764 methyldopa 94.69 µM 1.50065166180474 0.0357330455268177 no 190 0.0667228408422611 444 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent.
SGTC_3209 9113616 49.47 µM 1.49707261231724 0.0360648996444018 no 191 0.0671871825949296 460 16649353
SGTC_433 pimozide 108 µM 1.49450723547852 0.0363043142891829 no 192 0.06752154609354 322 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic
SGTC_76 0433-0009 400.328 µM 1.49445802638285 0.0363089194306766 no 193 0.0675279724053169 345 2841569
SGTC_1314 1222-0010 41.1 µM 1.48729908833611 0.0369839876053507 no 194 0.0684679176026757 401 3526027
SGTC_3319 9138450 16.7555 µM 1.4795791997611 0.0377234135998529 no 195 0.0694927904276323 410 2029690
SGTC_261 5-fluorouridine 15.376 µM 1.47510135911049 0.0381578109188045 no 196 0.0700926475609418 431 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_3270 9137563 49.47 µM 1.47249030718628 0.0384129875764752 no 197 0.0704442612772115 374 17015724
SGTC_2929 9013348 24.6 µM 1.45769945063566 0.0398848665536147 no 198 0.0724617017283228 447 2995952
SGTC_2650 prasterone 100 µM 1.45729128528146 0.0399261252754509 no 199 0.0725179957010462 338 16759247 A steroid and weak partial agonist of the androgen receptor.
SGTC_865 0488-0499 301 µM 1.45710388167664 0.0399450802758914 no 200 0.072543853536707 477 9634651
SGTC_1855 st056195 39.6 µM 1.45520748625346 0.0401373035764694 no 201 0.0728059145008615 442 4028379
SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM 1.45489655379935 0.0401688920456974 no 202 0.0728489510175251 427 6710655
SGTC_605 1315-0399 119 µM 1.4513042950393 0.040535305815981 no 203 0.0733475729246538 488 24020461
SGTC_1913 st060213 96.1 µM 1.45054398852135 0.0406132046564599 no 204 0.0734534408919199 481 688959
SGTC_1395 3486-0190 4.35 µM 1.45025474425755 0.0406428716870473 no 205 0.0734937470331104 470 6748079
SGTC_5 0352-0601 109.883 µM 1.44463477312548 0.0412227964255771 no 206 0.0742802500430069 394 762456
SGTC_294 k038-0071 157 µM 1.44376130295647 0.0413135292318766 no 207 0.0744030653297278 477 24152826
SGTC_3298 9116858 71.43 µM 1.44210297540632 0.0414862354565238 no 208 0.0746366629083031 451 2506942
SGTC_2677 mitomycin C 100 µM 1.44195961896853 0.0415011927185469 no 209 0.0746568828319527 374 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_2406 ethylparaben 405.7 µM 1.43518307681666 0.0422132309495203 no 210 0.0756174673723335 407 8434 A possible steroid mimic.
SGTC_426 0988-0037 14.6 µM 1.43367326560292 0.0423732118100767 no 211 0.0758327624143921 522 5383008
SGTC_1851 st056236 18.9 µM 1.43352599756074 0.0423888426725192 no 212 0.0758537874070884 462 5393171
SGTC_214 4373-3496 70 µM 1.43346150645197 0.0423956891537279 no 213 0.0758629959963532 636 3779166
SGTC_831 k061-1017 217 µM 1.42561502886156 0.0432353819468147 no 214 0.0769897478537303 625 1240153
SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM 1.42527325858755 0.0432722596607373 no 215 0.0770391135001805 442 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair.
SGTC_3346 9158254 43.5805 µM 1.41871798578712 0.0439845156604213 no 216 0.0779906257249205 482 17639500
SGTC_2991 9074669 71.4286 µM 1.41518748950896 0.0443720173887189 no 217 0.0785067657982417 545 17333109
SGTC_3246 9135460 32.98 µM 1.41490667552635 0.04440295683285 no 218 0.07854793023976 385 41446951
SGTC_1354 1498-1681 81 µM 1.41331318413325 0.0445788534279265 no 219 0.0787818295812719 515 5754243
SGTC_1230 0170-0365 3.77 µM 1.41181074632625 0.0447452128057532 no 220 0.0790028467047125 633 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1
SGTC_3155 9099265 49.47 µM 1.40918523830218 0.0450371254554868 no 221 0.0793902007603034 426 25236499
SGTC_402 epigallocatechin gallate 10 µM 1.40793933237955 0.0451761846328071 no 222 0.0795745175329046 506 65064 An antioxidant.
SGTC_265 mycophenolic acid 32.932 µM 1.40662057969353 0.0453237506021953 no 223 0.0797699636517521 516 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1
SGTC_1177 0983-0204 23.6 µM 1.40570341797451 0.0454266077060333 no 224 0.0799061057977268 508 766818
SGTC_2978 9011784 42.97 µM 1.40265890943794 0.0457693872706591 no 225 0.0803592879916914 556 2994934
SGTC_621 3584-0052 32.1 µM 1.3950354689849 0.0466368306804311 no 226 0.081502571994203 501 2273927
SGTC_2930 9013230 14.89 µM 1.38591477405717 0.0476919203229039 no 227 0.0828864644789468 531 2995857
SGTC_2299 7976368 114.88 µM 1.38476760529546 0.0478259685858924 no 228 0.0830617697132738 466 2979718
SGTC_2078 5212016 200 µM 1.37805415818641 0.0486165031476686 no 229 0.0840932837965272 429 1899708
SGTC_845 0330-0138 4.51 µM 1.37733004759446 0.0487023905459957 no 230 0.0842051146902998 491 9039800
SGTC_196 k015-0023 18.111 µM 1.37674397966188 0.0487719933520891 no 231 0.084295708122662 526 5211998
SGTC_1556 plumbagin 1.48 µM 1.37400296704709 0.0490985785133246 no 232 0.0847203806503673 425 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_370 0180-0345 38.7 µM 1.37373542792719 0.0491305485128312 no 233 0.0847619170017934 442 3989527
SGTC_3261 9137475 49.47 µM 1.36936704452754 0.049654910965004 no 234 0.0854422851586693 287 17027690
SGTC_29 0299-0004 12.984 µM 1.35472942697771 0.0514445663704574 no 235 0.0877518893464967 402 16871 A napthoquinone isolated from Swertia calycina.
SGTC_552 k242-0005 476 µM 1.35443837690316 0.0514806647530253 no 236 0.0877982804648406 487 4088318
SGTC_3144 9087057 49.47 µM 1.35324480936213 0.0516289113791936 no 237 0.0879887171963776 506 17249618
SGTC_847 0342-0274 5.54 µM 1.3465069615806 0.0524721595385421 no 238 0.0890695383964053 512 18097
SGTC_2167 5876490 200 µM 1.34252308161174 0.0529758664047187 no 239 0.0897132257736945 527 686534
SGTC_180 1486-1293 102.781 µM 1.34040352843927 0.0532454134103333 no 240 0.0900570946099937 511 4140536
SGTC_1818 st052136 56.3 µM 1.33972605671465 0.0533317974956813 no 241 0.090167211504058 521 674169
SGTC_182 3448-4371 550.524 µM 1.33921344379159 0.0533972343078792 no 242 0.0902505985434233 549 3491403
SGTC_2317 5986382 200 µM 1.33821714822329 0.0535245968767617 no 243 0.0904128303385307 523 877883
SGTC_2507 purpurin 79.67 µM 1.3371653404916 0.0536593169579718 no 244 0.0905843363267287 540 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1
SGTC_821 1114-0266 29.2 µM 1.33356562633689 0.0541224174499322 no 245 0.0911731272327346 501 3123235
SGTC_1989 st071868 50.2 µM 1.3275767018565 0.054899890949378 no 246 0.0921589927265229 544 16414057
SGTC_156 3474-0145 5.642 µM 1.32610541991519 0.0550922348351146 no 247 0.0924023905658881 518 2265471
SGTC_808 0711-0032 135 µM 1.32601363893996 0.0551042511811074 no 248 0.092417589868772 502 4252555
SGTC_1229 0139-0193 12.2 µM 1.32490776328096 0.0552491998445383 no 249 0.092600872834969 559 3090752
SGTC_1261 0712-0010 12.7 µM 1.32456940515507 0.0552936090296479 no 250 0.0926570045055245 567 2840123
SGTC_3136 9095672 49.47 µM 1.32279786033218 0.0555265829879932 no 251 0.0929513044926695 453 17217380
SGTC_2518 prenyletin 46.28 µM 1.3217464241729 0.0556652222477541 no 252 0.0931263020422677 423 3873459 A coumarin with calcium channel inhibitory activity.
SGTC_859 0439-0102 54.6 µM 1.32026017414469 0.0558616606314978 no 253 0.0933740837490989 579 610143
SGTC_2916 7875993 68.79 µM 1.31885279262099 0.0560481786845502 no 254 0.0936091654349304 525 1299250
SGTC_2163 5671233 125 µM 1.31419449377457 0.0566690408298489 no 255 0.0943903805007173 583 701023
SGTC_488 nitrendipine 139 µM 1.31233182555574 0.056918810127984 no 256 0.0947040992160226 575 4507 Dihydropyridine L-type calcium channel blocker.
SGTC_1679 SEC14.276 6.7 µM 1.3114355189309 0.0570393063914212 no 257 0.0948553326669913 611 1005053 YMR079W SEC14
SGTC_600 1495-0418 41.6 µM 1.309695264734 0.0572738333641697 no 258 0.0951494730674478 503 5377768
SGTC_3067 9117431 49.47 µM 1.30799093732601 0.0575042534865683 no 259 0.0954381915923752 482 17150885
SGTC_2821 7996764 71.43 µM 1.30483663157294 0.0579326295199449 no 260 0.0959742413434158 571 2987135
SGTC_2106 5357045 167.29 µM 1.30472695121431 0.05794756985683 no 261 0.0959929204202308 559 668842
SGTC_1636 st007707 68.9 µM 1.30361162948148 0.0580996677419118 no 262 0.096183016746884 601 403051
SGTC_2273 7815444 169.05 µM 1.30172421753209 0.0583577709818998 no 263 0.096505338906629 505 2824616
SGTC_1117 retinoic acid 1.10837 µM 1.30028018920088 0.0585558489890339 no 264 0.0967524777010642 589 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR).
SGTC_3226 9131256 49.47 µM 1.28711065984734 0.0603867642328706 no 265 0.0990278602416912 406 17178073
SGTC_281 1672-3440 14.9 µM 1.28587852107074 0.0605603311254294 no 266 0.0992427304414324 599 6833000
SGTC_753 1322-0200 289 µM 1.28553706202483 0.0606085002160157 no 267 0.0993023370801079 549 5403907
SGTC_2280 7785178 200 µM 1.28547732859592 0.0606169297961365 no 268 0.099312767107593 521 2954328
SGTC_807 1315-0151 48 µM 1.28378567408009 0.0608560370123832 no 269 0.0996084787592346 640 4011080
SGTC_2858 9025781 8.96 µM 1.28367968812594 0.0608710421314683 no 270 0.0996270271539338 688 4894980 YPL153C RAD53
SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM 1.28366108567291 0.0608736760998293 no 271 0.0996302829932318 605 676296 Flavone; oxidizing agent.
SGTC_3281 9140613 49.47 µM 1.27831936717948 0.0616337172886968 no 272 0.100568420884805 504 16013766
SGTC_2360 9040895 200 µM 1.2735508735735 0.0623184391232137 no 273 0.101411316035799 525 4914414
SGTC_714 4296-0578 26.1 µM 1.26927667889479 0.0629372119660683 no 274 0.102171200518472 481 1589775
SGTC_188 3229-0966 278.469 µM 1.26918359337345 0.0629507409679441 no 275 0.102187795619826 663 5722370
SGTC_2003 4023581 200 µM 1.26883712706391 0.0630011161130475 no 276 0.102249580174311 553 16641307
SGTC_3087 9117406 49.47 µM 1.2687702309658 0.0630108462175096 no 277 0.102261512733382 548 42546093
SGTC_3090 9117696 49.47 µM 1.26690096087915 0.06328320703394 no 278 0.102595352558268 534 7923821
SGTC_695 3505-6186 243 µM 1.26300171232246 0.0638542938805072 no 279 0.103294282171481 581 1819379
SGTC_2859 9028643 45.46 µM 1.26247354783513 0.0639319565183164 no 280 0.103389219414805 525 17151580
SGTC_1143 3454-2408 5.08 µM 1.25805342655517 0.0645847849916291 no 281 0.104186217543379 510 X1143
SGTC_2218 6965428 192.983 µM 1.25627932057922 0.0648482626869986 no 282 0.104507358388583 583 675684
SGTC_129 0088-0017 176.636 µM 1.25564118839968 0.0649432373826913 no 283 0.104623045454257 545 182446
SGTC_1435 4092-0789 56.7 µM 1.2549256964083 0.0650498540853044 no 284 0.104752867368983 579 2248285
SGTC_1911 st060208 74.3 µM 1.25414363095044 0.0651665463561981 no 285 0.104894902057483 619 688783
SGTC_2448 5185112 27.17 µM 1.25341392961818 0.0652755717805602 no 286 0.105027552336113 526 5718189
SGTC_2121 5257820 149.641 µM 1.25337125163219 0.0652819527198637 no 287 0.105035314399587 624 791256
SGTC_2639 lactacystin 53 µM 1.24856112858226 0.0660042372458553 no 288 0.105912818608566 625 3870 A proteasome inhibitor.
SGTC_143 4032-1194 15.74 µM 1.24527792403391 0.0665007857497088 no 289 0.106514803762833 681 1806963
SGTC_1927 st060202 13.8 µM 1.2446196907924 0.0666006833851527 no 290 0.106635789425604 577 688887
SGTC_2722 naftopidil 47.16 µM 1.24316892412281 0.0668212709888529 no 291 0.106902795771109 613 4418 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_1491 4138-0063 26.5 µM 1.24122592718608 0.0671175866825725 no 292 0.10726114972747 549 23883227
SGTC_2927 9011802 47.9 µM 1.24076326449071 0.067188294368292 no 293 0.107346607806078 571 43912568
SGTC_4 0960-0234 25.671 µM 1.23979270596005 0.0673368097439623 no 294 0.107526038397926 543 6821112
SGTC_2960 9079389 5.97 µM 1.23907585571736 0.0674466653808721 no 295 0.107658703743986 600 16457355
SGTC_1814 st052110 31.539 µM 1.23795667156741 0.0676184546287326 no 296 0.10786606355221 555 674163
SGTC_1343 1487-0095 224 µM 1.23480122892289 0.0681046198713881 no 297 0.108452244951225 564 4560101 YGL055W OLE1
SGTC_101 0490-5701 117.494 µM 1.23456393898747 0.0681412884048786 no 298 0.108496418390016 536 4661669
SGTC_3211 9128781 49.47 µM 1.2304665355048 0.068776868474702 no 299 0.109261225516703 587 17194361
SGTC_1941 st076221 61.8 µM 1.22898617579494 0.0690076193052733 no 300 0.109538494596839 649 2828568
SGTC_754 3474-0146 171 µM 1.22310889644448 0.0699296300265931 no 301 0.110644284440134 564 24762078
SGTC_2461 5755302 26.15 µM 1.22258960298657 0.0700115489162831 no 302 0.110742371012624 638 2788904
SGTC_1448 4255-0083 152 µM 1.21073297772764 0.0719020927313642 no 303 0.112998879580144 631 5399660
SGTC_2475 5812728 15.03 µM 1.21007049017115 0.07200887033031 no 304 0.113125922765592 635 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2
SGTC_190 3970-0790 3.722 µM 1.20959088894166 0.072086246737091 no 305 0.113217957983695 574 2832352
SGTC_3292 9120825 59.784 µM 1.20914314839024 0.0721585404172235 no 306 0.113303927357656 625 24824900
SGTC_2342 7990637 118.86 µM 1.20724823502005 0.072465114845133 no 307 0.113668279754456 633 2033102 YER133W GLC7
SGTC_897 1000-0139 31.4 µM 1.20466794120589 0.0728841788930195 no 308 0.114165758429068 616 6151020
SGTC_1256 0570-0116 285 µM 1.19715962567393 0.074114154932099 no 309 0.115622171616065 586 410638
SGTC_1685 st024049 53.0905 µM 1.19701044730029 0.0741387522733853 no 310 0.115651241359926 590 1941139
SGTC_1738 st035555 74 µM 1.19524794024747 0.0744298362573522 no 311 0.115995086552577 627 5331140
SGTC_3306 9127676 59.7925 µM 1.19521012326417 0.0744360914074465 no 312 0.116002472162803 591 41905287
SGTC_2044 5102272 200 µM 1.18899675148758 0.0754692792013307 no 313 0.117220472625625 575 592666
SGTC_2831 7999036 19.48 µM 1.18721769443333 0.0757671123389108 no 314 0.117570881572679 655 2988270
SGTC_2994 9053520 71.4286 µM 1.18622637124756 0.0759334583819085 no 315 0.117766457268214 629 4647384
SGTC_230 MPP+ 141.667 µM 1.18537367337023 0.0760767651730443 no 316 0.117934868017062 600 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death.
SGTC_998 3996-0085 177 µM 1.17193442145205 0.0783626839357849 no 317 0.120611693006658 705 715391
SGTC_135 0933-0004 26.348 µM 1.17097775175747 0.0785273710096384 no 318 0.120803860044912 616 21230617 YGL099W LSG1
SGTC_922 1866-0035 480 µM 1.17092087544881 0.0785371703076893 no 319 0.120815291619251 743 3156169
SGTC_3244 9134489 49.47 µM 1.16888003995672 0.0788894023554904 no 320 0.121225983211193 632 16584271
SGTC_2097 5376186 200 µM 1.16848715643425 0.0789573480972891 no 321 0.121305158479425 653 742755
SGTC_2620 irigenin 100 µM 1.16380050669183 0.0797712843848184 no 322 0.122252433386615 656 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro.
SGTC_2871 9038510 12.99 µM 1.16147216284606 0.0801780030373475 no 323 0.122724968671333 700 4945164
SGTC_2919 7978188 46.38 µM 1.15553822947988 0.0812216372917235 no 324 0.123935043399642 669 2980291
SGTC_2491 paeonol 100 µM 1.15288367426561 0.0816918135022358 no 325 0.124479066927512 625 11092 Increases levels of cortical cytochrome oxidase.
SGTC_1891 st059073 26.2 µM 1.15074529590897 0.0820720540516399 no 326 0.124918517948569 713 688754
SGTC_2709 st078560 56 µM 1.15033303376045 0.0821455144373131 no 327 0.125003365040157 665 17250903
SGTC_2351 9026858 72.31 µM 1.14673711117833 0.0827883680278768 no 328 0.125745143850059 618 1409300
SGTC_1259 0671-0132 43 µM 1.14374732367135 0.0833257371257708 no 329 0.126364220634238 657 X1259
SGTC_266 formosanin C 406 nM 1.13909276055695 0.0841675368817819 no 330 0.12733223334315 688 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1
SGTC_1979 st071809 45.3 µM 1.1371617023091 0.0845186454864888 no 331 0.127735346843869 689 4976333
SGTC_489 paxilline 115 µM 1.13655105843739 0.0846299022407039 no 332 0.127863004763616 627 105008 A toxic potassium channel blocker.
SGTC_704 1310-0270 142 µM 1.13465315313006 0.0849763938832746 no 333 0.128260336494559 692 5718033
SGTC_3146 9095609 49.47 µM 1.1332161627176 0.0852394450149189 no 334 0.128561744184913 696 17173999
SGTC_31 0508-1974 57.237 µM 1.13229945631067 0.0854075729850024 no 335 0.128754279309654 664 6810525
SGTC_597 k018-0003 82.8 µM 1.13156045186555 0.0855432903719163 no 336 0.12890963739783 745 6786234
SGTC_399 oxolinic acid 75 µM 1.13036962285941 0.085762324557885 no 337 0.129160254306465 660 4628 A DNA gyrase inhibitor.
SGTC_169 k015-0017 16.025 µM 1.12827860541597 0.0861479495740754 no 338 0.12960113798851 616 1840002
SGTC_643 k048-0106 28.4 µM 1.128072871431 0.086185960970623 no 339 0.129644572538976 693 6763920
SGTC_454 lyso-paf C-16 6.67 µM 1.12804891131642 0.0861903886551959 no 340 0.129649631652803 645 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_2856 9022925 19.48 µM 1.12554308621945 0.0866543899708387 no 341 0.130179485000206 687 4944862
SGTC_1509 1326-1131 80 µM 1.12392497193347 0.0869550051647876 no 342 0.130522428224578 651 768313
SGTC_783 0848-0141 92.7 µM 1.12080980925851 0.0875359362488359 no 343 0.131184413918312 654 6755076 YHR007C | YLR033W ERG11 | RSC58
SGTC_2696 st077691 74.316 µM 1.12040376973408 0.0876118693852788 no 344 0.131270869621933 605 757133
SGTC_798 1287-0182 476 µM 1.11962285058853 0.0877580466116357 no 345 0.13143725691862 754 1649755
SGTC_1209 2323-2347 50.3 µM 1.11879043230183 0.0879140640092454 no 346 0.131614777185833 679 5412760
SGTC_2685 mycophenolic acid 18.85 µM 1.11641852356775 0.0883597573525087 no 347 0.132121514080592 658 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_2456 5770359 74.46 µM 1.11594667045105 0.0884486213259093 no 348 0.132222481452866 716 3118787
SGTC_1114 scopoletin 1.73284 µM 1.11574721616761 0.0884862045148076 no 349 0.132265176773242 695 5280460 A coumarin with genotoxic properties.
SGTC_515 4092-1064 102 µM 1.11574012308871 0.0884875412833629 no 350 0.132266695297536 760 717353
SGTC_882 0843-0131 351 µM 1.11468857475579 0.0886858835983866 no 351 0.132491949356418 750 5425421
SGTC_2884 9058502 51.95 µM 1.11176471159562 0.0892391207044241 no 352 0.133119664074957 701 6471554
SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM 1.11017811577955 0.0895404002515936 no 353 0.133461140537937 679 4330530
SGTC_1323 1348-1351 11.2 µM 1.10695335925273 0.0901550810245954 no 354 0.134157047029152 658 6989654
SGTC_2519 cryptotanshinone 88.04 µM 1.10693581383473 0.090158433963355 no 355 0.134160840157654 694 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE)
SGTC_663 1486-0733 13.9 µM 1.1065346788913 0.0902351163365109 no 356 0.134247581264906 740 722445 YPR165W RHO1
SGTC_1156 4092-0367 4.88 µM 1.10345465483716 0.0908255192726721 no 357 0.13491488654532 706 1357585
SGTC_2216 7189485 200 µM 1.09955100600213 0.0915779134073615 no 358 0.135763899421906 727 731273
SGTC_875 0709-0210 25.7 µM 1.09547007901332 0.0923694041098209 no 359 0.136655373498079 756 6251364
SGTC_886 0866-0150 153 µM 1.09129433020685 0.0931845137968542 no 360 0.137571695892925 753 271463
SGTC_2021 4019055 173 µM 1.09041439244022 0.0933569543927903 no 361 0.137765322391705 837 44827708 YER133W GLC7
SGTC_1186 1319-0216 26 µM 1.08758783825828 0.0939124663720094 no 362 0.138388551037575 757 4565136
SGTC_1830 st055982 50.3 µM 1.08660310959654 0.0941065702148143 no 363 0.138606125102799 727 455313 An antimicrobial agent.
SGTC_534 k292-0788 63.4 µM 1.08452908938767 0.0945163566225946 no 364 0.13906513820431 805 4146317
SGTC_3100 9120536 49.47 µM 1.07987641101578 0.0954404192503059 no 365 0.14009860944499 597 16421196
SGTC_1170 0310-0127 64.8 µM 1.07896084850956 0.0956230383815902 no 366 0.140302590642537 745 774975
SGTC_985 1493-0307 8.71 µM 1.07246359222297 0.0969263801034571 no 367 0.141755929152709 677 3278274
SGTC_2949 9072542 2.23 µM 1.07107959704804 0.097205684955177 no 368 0.14206682064533 731 16457352
SGTC_228 caffeine 993.056 µM 1.06998542636389 0.0974269178528727 no 369 0.142312934323113 690 2519 Caffeine is a phosphodiesterase inhibitor.
SGTC_1553 gossypol 38.6 µM 1.06740492767913 0.0979501370653345 no 370 0.14289451212806 641 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_1093 fluphenazine 7.97 µM 1.06594483005923 0.098247095631043 no 371 0.143224291020123 754 6602611 An atypical antipsychotic.
SGTC_941 3237-0776 460 µM 1.06356370528875 0.0987327888968814 no 372 0.143763195814116 706 760008
SGTC_3252 9135871 49.47 µM 1.06334579556904 0.0987773249489405 no 373 0.143812582176016 733 17682838
SGTC_628 1636-0253 16 µM 1.06321522910472 0.0988040169636221 no 374 0.143842178825007 754 4456143
SGTC_335 4077-0256 27.6 µM 1.06139973449502 0.0991757099486968 no 375 0.144254138765704 822 3121989
SGTC_1962 st076595 64.5 µM 1.05957108567217 0.0995511286905663 no 376 0.144669886827707 739 279619
SGTC_699 0375-0592 111 µM 1.05848733659679 0.0997741102480542 no 377 0.144916660525316 776 762578
SGTC_743 1275-0778 158 µM 1.05828117351408 0.0998165696111955 no 378 0.144963636691498 787 2849257 YMR203W TOM40
SGTC_3328 9140624 29.0385 µM 1.05554382554661 0.100381578968578 no 379 0.145588338433539 784 4904392
SGTC_186 3455-3465 67.277 µM 1.05377184368682 0.100748571724043 no 380 0.145993693666627 669 755278
SGTC_2593 nobiletin 86.24 µM 1.04841669162456 0.101863615159409 no 381 0.147223333258955 694 72344 An anti-infammatory.
SGTC_1373 2887-0003 58.5 µM 1.04651926259539 0.102260842860391 no 382 0.147660678105369 728 776948
SGTC_342 k048-0088 23.3 µM 1.04510194372087 0.102558293542873 no 383 0.147987927912399 741 6820570
SGTC_759 3486-0358 89.3 µM 1.0444765346438 0.102689747070356 no 384 0.148132485094055 828 875103
SGTC_2744 captopril 92.04 µM 1.04073804785915 0.103478086879884 no 385 0.148998569821169 695 44093 angiotensin-converting enzyme (ACE) inhibitor
SGTC_3010 9080089 71.4286 µM 1.03616082580754 0.10444926162184 no 386 0.150063559591661 772 17027233
SGTC_2333 9017922 200 µM 1.03476258093033 0.104747247769819 no 387 0.1503899009918 762 3163164
SGTC_2180 6301957 200 µM 1.0339192087621 0.104927279938253 no 388 0.150586967103881 798 845462
SGTC_2196 6573537 42.6665 µM 1.03058666575319 0.105640859432663 no 389 0.15136734586403 765 2903087
SGTC_2036 5160441 105 µM 1.02976105782241 0.105818183477923 no 390 0.15156109270754 832 134534 YIL048W NEO1
SGTC_2492 derrusnin 100 µM 1.02971824359859 0.105827384979849 no 391 0.151571144489942 700 1715307 Part of coumarin class of compounds.
SGTC_3251 9135047 49.47 µM 1.02959470636021 0.105853938466845 no 392 0.151600150639887 745 17682963
SGTC_3018 9082602 49.47 µM 1.02887341666364 0.106009070911593 no 393 0.151769580823567 802 17332089
SGTC_2 0422-0095 29 µM 1.02884828619301 0.106014478844597 no 394 0.151775486211956 646 6790840
SGTC_1507 4075-3230 155 µM 1.0285727046901 0.106073795481194 no 395 0.151840254897997 699 659771
SGTC_2316 5844804 197.44 µM 1.02855214519327 0.106078221703637 no 396 0.151845087640451 914 776813
SGTC_895 0964-0006 13.7 µM 1.0281195129445 0.106171393385176 no 397 0.15194680644984 769 6738897
SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM 1.02654119017402 0.106511802183694 no 398 0.152318279259745 868 551469
SGTC_282 k297-0036 65.7 µM 1.02468994197727 0.106912078129847 no 399 0.152754755185576 765 5061378
SGTC_1798 st045719 60.953 µM 1.02297130987299 0.107284650247051 no 400 0.153160705536043 739 3980186
SGTC_132 0417-1715 25.805 µM 1.02167906469144 0.107565404335061 no 401 0.153466411430638 812 6769098
SGTC_1384 3089-0840 101 µM 1.01963205565819 0.108011221868686 no 402 0.153951498105681 745 1069836
SGTC_1008 4106-0037 6 µM 1.01874734794409 0.108204313325559 no 403 0.154161463970249 774 2905394
SGTC_334 1502-1024 68.5 µM 1.01812524496333 0.108340238815455 no 404 0.154309219763507 799 3296216
SGTC_2094 5332512 191.667 µM 1.01213001652961 0.109656458844383 no 405 0.155737946067544 828 755774
SGTC_372 0155-0182 15.9 µM 1.01070325210717 0.109971381443114 no 406 0.156079240035703 851 771486
SGTC_3069 9117009 49.47 µM 1.01028018234352 0.110064888150506 no 407 0.156180536529947 664 41904981
SGTC_2101 5377231 179.231 µM 1.0073742876891 0.110708689471572 no 408 0.15687747133536 794 2844213
SGTC_2596 sinensetin 100 µM 1.00732805157862 0.110718954852246 no 409 0.156888576878682 732 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets.
SGTC_1739 st037196 92.5 µM 1.00698064928653 0.110796107222285 no 410 0.156972036670078 853 612214
SGTC_982 1491-0518 27.5 µM 1.00443742872437 0.111362088318506 no 411 0.157583908375594 746 3091256
SGTC_410 α-linolenic acid 100 µM 1.00320325772978 0.111637491523237 no 412 0.157881400749512 825 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_1946 st076057 65.1 µM 1.00227519064758 0.111844908885489 no 413 0.158105350681321 668 953009
SGTC_1921 5740136 50 µM 0.998541062479626 0.112682248977429 no 414 0.159008531617384 846 1774243
SGTC_2073 5212005 126 µM 0.998130046277135 0.112774687932487 no 415 0.159108151041123 716 691789
SGTC_1445 4239-0156 97.7 µM 0.9964099749572 0.113162125278274 no 416 0.159525494181955 889 4008346
SGTC_3266 9136860 49.47 µM 0.992181328758427 0.114118641236011 no 417 0.160554539432274 803 4871271 YPR165W RHO1
SGTC_195 4234-0266 16.654 µM 0.989950808121523 0.114625496715725 no 418 0.161099081824009 855 2303354
SGTC_337 1315-0038 354 µM 0.989752786082158 0.114670571836901 no 419 0.161147483600194 808 1626437
SGTC_2531 methyl deoxycholate 70.07 µM 0.985509877927008 0.115639403265191 no 420 0.162186840903105 760 16667744 Haematoxylin.
SGTC_2033 5192550 145 µM 0.98461561738117 0.115844339698397 no 421 0.162406457729233 784 182073
SGTC_1388 3346-4487 254 µM 0.984432574670368 0.115886319117057 no 422 0.162451434094562 867 3345614
SGTC_2954 9074818 52.69 µM 0.984352720834618 0.115904636355358 no 423 0.162471057930267 797 16648742
SGTC_2829 7992743 58.44 µM 0.98072328806078 0.116739343303425 no 424 0.163364608237968 839 16462845
SGTC_163 TUB2.036 7.546 µM 0.980187063595887 0.116863026118357 no 425 0.163496894488809 939 15992207 YJR013W GPI14
SGTC_1330 1469-0054 61.8 µM 0.979624474157206 0.116992889959644 no 426 0.163635759724006 887 7102664
SGTC_2872 9044037 25.97 µM 0.979176297741104 0.117096416734124 no 427 0.163746438915423 792 6465195
SGTC_656 4090-1979 187 µM 0.977539559650599 0.117475047323443 no 428 0.16415105145415 883 22330961
SGTC_3342 9147791 14.508 µM 0.97522360157546 0.118012283355855 no 429 0.164724678647941 823 1838168
SGTC_1141 3253-0389 52.6 µM 0.974689579570082 0.118136407367455 no 430 0.164857131710276 829 5402031
SGTC_1889 st059080 5.18 µM 0.974652629588118 0.118144999154002 no 431 0.164866298936392 875 176925 Isolated from Daphnopsis sellowiana.
SGTC_2230 bromochlorosalicylanilide 954.5 nM 0.971491542610136 0.118881666866743 no 432 0.16565178131972 775 77254
SGTC_1451 4152-0210 104 µM 0.970774729605991 0.119049165042678 no 433 0.165830234573796 861 659563
SGTC_1988 st071872 53.4 µM 0.97041296793648 0.119133761372182 no 434 0.165920343648739 872 16414116
SGTC_1130 3454-2858 15.9 µM 0.969251150650538 0.119405734053032 no 435 0.166209947811873 797 715628 YIL048W NEO1
SGTC_3297 9117502 71.43 µM 0.968861096836451 0.119497140870215 no 436 0.166307249009271 855 7453720
SGTC_2220 6782180 200 µM 0.968856293021119 0.119498266923728 no 437 0.166308447578271 741 833803
SGTC_2403 6032726 181.2 µM 0.967856976430465 0.119732677662235 no 438 0.166557901898755 794 2881040
SGTC_935 2996-0153 430 µM 0.966418905543316 0.120070576229615 no 439 0.166917303847121 844 23738523
SGTC_2428 5615643 7.78 µM 0.962719611279235 0.120942872929462 no 440 0.167844126135458 815 2253075
SGTC_219 mitoxanthrone 164.414 µM 0.962691339419393 0.120949556582935 no 441 0.167851222108946 784 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA. YMR168C CEP3
SGTC_185 k048-0037 25.491 µM 0.958045161247534 0.122051476525941 no 442 0.169019993135297 873 6827589
SGTC_1085 doxorubicin 7.67 µM 0.95695314884994 0.122311485808841 no 443 0.169295451545501 905 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_2845 9003024 42.97 µM 0.956530855649377 0.122412138430899 no 444 0.169402051565312 860 2990173
SGTC_1032 k061-1018 98.7 µM 0.955829474944937 0.122579439345348 no 445 0.16957919717324 928 4005393
SGTC_1489 4065-0444 182 µM 0.954681267192057 0.12285366842616 no 446 0.169869452966498 843 2877968
SGTC_469 w7 172 µM 0.95458628532309 0.12287637241329 no 447 0.169893477719256 835 45115570 A P450 inhibitor.
SGTC_1280 0880-0253 10.1 µM 0.953172197628923 0.123214736809012 no 448 0.170251415265256 845 6836607
SGTC_1368 1852-0141 284 µM 0.951048030939967 0.123724235844639 no 449 0.170789997110463 815 2838987
SGTC_3105 9121040 49.47 µM 0.949834289981862 0.124016023031056 no 450 0.171098229753115 647 41448907
SGTC_939 1165-0479 45.3 µM 0.948993481048938 0.124218438295698 no 451 0.171311963815844 865 1377347
SGTC_666 0272-0154 136 µM 0.948524896949864 0.124331344862987 no 452 0.171431152171117 857 6870312
SGTC_645 0845-0943 5.41 µM 0.948059436822929 0.124443569738133 no 453 0.171549598375449 822 1885106
SGTC_3164 9100705 49.47 µM 0.94476252609219 0.125240499914167 no 454 0.172390063714443 839 17174235
SGTC_2085 5307070 144.047 µM 0.943152710254701 0.125630917055742 no 455 0.172801398944671 804 2840351
SGTC_2997 9067075 71.4286 µM 0.942109617784624 0.125884343748967 no 456 0.173068260449392 880 27209819
SGTC_463 ikarugamyin 104 µM 0.941689997156216 0.125986394042489 no 457 0.17317568888168 860 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis.
SGTC_1569 carminic acid 40.6 µM 0.940702522246052 0.12622677209971 no 458 0.173428663042292 893 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_2704 st078022 71.1 µM 0.940067584422689 0.126381501853254 no 459 0.173591447424848 885 54697681
SGTC_69 0096-0274 206.684 µM 0.94002761932808 0.126391245476716 no 460 0.173601696865753 912 6741392
SGTC_109 0132-0036 33.701 µM 0.938529711074681 0.126756818005851 no 461 0.173986127807116 743 67274 A color developer.
SGTC_2598 perillyl alcohol 100 µM 0.937339625224403 0.127047789200198 no 462 0.174291943150079 871 10819 An apoptosis inducer.
SGTC_3194 9111903 49.47 µM 0.935388932852096 0.127525730394242 no 463 0.174793949147658 836 17087251
SGTC_1007 4101-0031 70 µM 0.933581773930615 0.127969618592079 no 464 0.17525983527676 893 1146276
SGTC_198 3454-2873 16.191 µM 0.928968300239639 0.129107679715972 no 465 0.176452757369277 857 710957
SGTC_2627 acetyl isogambogic acid 100 µM 0.928105607106387 0.129321266995006 no 466 0.176676395682064 829 6857789 A caspase activator and apoptosis inducer.
SGTC_2907 7721985 69.9 µM 0.927395585251211 0.129497239235566 no 467 0.176860590986349 870 3267881
SGTC_2798 7813637 45.45 µM 0.926727739084916 0.12966290997546 no 468 0.17703395571936 856 956368
SGTC_2240 6690706 185.951 µM 0.926074222765431 0.129825168003847 no 469 0.17720370449959 759 805876
SGTC_436 n,n-dimethylsphingosine 3.3 µM 0.924870582487308 0.130124381140503 no 470 0.177516615148494 895 5282309
SGTC_491 tetrandrine 80.3 µM 0.924709629925116 0.130164428510698 no 471 0.177558484444797 859 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_1291 0993-0025 5.79 µM 0.923480933923056 0.130470427258643 no 472 0.177878315894593 910 4353356
SGTC_2515 chrysin 20.77 µM 0.922832529981424 0.13063210843452 no 473 0.178047242808144 902 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor.
SGTC_2708 st078559 56 µM 0.918909526002028 0.131613273707472 no 474 0.179071448447187 807 17250902
SGTC_844 0330-0132 15.3 µM 0.918888568526733 0.131618528910998 no 475 0.179076929894289 949 2828079
SGTC_2014 4013930 200 µM 0.918201018225115 0.131791016286672 no 476 0.179256817849829 953 64556
SGTC_73 0327-0325 16.231 µM 0.917458102468549 0.131977568554324 no 477 0.17945131909554 973 53298
SGTC_814 3342-0569 96 µM 0.915497204067856 0.132470840776961 no 478 0.179965334796491 905 4346283
SGTC_2119 5528445 120.635 µM 0.912341183595535 0.133267415885509 no 479 0.180794570486168 918 791935
SGTC_989 1501-0895 10.3 µM 0.911112148622424 0.133578512404063 no 480 0.181118143007178 929 2830112
SGTC_3133 9127736 49.47 µM 0.910746591213214 0.133671139524594 no 481 0.181214454595245 896 27243420
SGTC_1650 st011916 45.8 µM 0.905621481548015 0.134974420948901 no 482 0.182568117357841 916 242528
SGTC_2035 5154463 94.595 µM 0.905457085447044 0.135016369559848 no 483 0.182611642534099 895 2769623
SGTC_2787 5284540 71.43 µM 0.902034717963232 0.135891678852442 no 484 0.183519212705708 899 736958
SGTC_1115 galangin 695.678 nM 0.901351780800517 0.136066811784653 no 485 0.183700655234653 994 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_379 3970-0972 5.9 µM 0.899400980313624 0.136567927271642 no 486 0.184219558612957 892 2898042 YBL034C STU1
SGTC_551 k048-0028 34.9 µM 0.896492268333498 0.137317449372723 no 487 0.184994953919381 959 6836383
SGTC_2281 7943571 200 µM 0.894880716098079 0.13773392422158 no 488 0.185425428129006 1008 1244024
SGTC_1601 4'-hydroxyflavanone 55.5 µM 0.890655581204395 0.138829918672452 no 489 0.186556985649036 950 165506
SGTC_1797 st048695 56.8 µM 0.890624851384362 0.138837911641703 no 490 0.186565231209988 924 592262 YIL048W NEO1
SGTC_1044 1222-0021 1.78 µM 0.888693345741465 0.139340934203967 no 491 0.187083954137455 894 4306703
SGTC_2041 5107442 45.335 µM 0.888611689871923 0.139362227148296 no 492 0.18710590318006 936 793005
SGTC_775 4577-0580 57.3 µM 0.887938548631462 0.139537842764799 no 493 0.187286903770553 931 2006902
SGTC_3207 9114163 49.47 µM 0.88728867942067 0.139707529682614 no 494 0.187461749428055 978 849233
SGTC_363 0455-0021 3.06 µM 0.887036506063259 0.139773412266953 no 495 0.187529623188141 914 4597466
SGTC_1746 st038117 42 µM 0.885375293885293 0.140207946874064 no 496 0.187977126454178 905 2898218
SGTC_2915 7971052 15.16 µM 0.882888598415647 0.140860122010229 no 497 0.1886482322201 779 5741558
SGTC_1502 4534-4282 27.7 µM 0.880755738703781 0.141421135277864 no 498 0.18922502046282 896 3278949
SGTC_1113 artemisinin 1.17947 µM 0.879515646203864 0.141748016220202 no 499 0.189560876728027 967 2240 An anti-malaria and mitochondrial poison.
SGTC_1587 estradiol valerate 56.1 µM 0.877153096017624 0.142372185448075 no 500 0.190201744198943 974 13791 A steroid.
SGTC_1871 st057448 67.3 µM 0.874965808759917 0.142951706613128 no 501 0.190796254889419 967 691747
SGTC_1714 st033236 13.627 µM 0.874199194021483 0.14315519771539 no 502 0.191004892445197 956 2916566
SGTC_3188 9110789 49.47 µM 0.873048716499199 0.143460948806276 no 503 0.191318262387865 944 849217
SGTC_3236 9132701 49.47 µM 0.872032484565064 0.143731389214791 no 504 0.191595328123405 924 24282524
SGTC_2948 9070189 9.45 µM 0.871385431439947 0.143903762616656 no 505 0.191771868852575 855 6473636 YDL196W YDL196W
SGTC_2675 theaflavin digallate 100 µM 0.869758898877914 0.144337682623195 no 506 0.192216088551807 965 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative.
SGTC_130 0136-0219 337.655 µM 0.869480350306659 0.144412081074716 no 507 0.192292225583665 945 234244
SGTC_1394 3474-0001 65.7 µM 0.86675228066931 0.14514209605969 no 508 0.193038876653472 835 5017666 YIL048W NEO1
SGTC_1560 lithocholic acid 53.1 µM 0.865825487438162 0.145390664524655 no 509 0.193292934944167 902 9903 A bile acid which acts as a detergent.
SGTC_3190 9110366 49.47 µM 0.86508706807981 0.145588915448951 no 510 0.193495501008346 881 17123768
SGTC_533 1222-0222 6.71 µM 0.864728675274793 0.145685202286129 no 511 0.193593863372995 986 3982874
SGTC_1449 4112-4002 201 µM 0.864158047891924 0.145838597000416 no 512 0.193750537296923 887 2059539
SGTC_2038 4100038 30.985 µM 0.863616945005294 0.145984155245251 no 513 0.193899176230398 927 3596803
SGTC_2648 atorvastatin 78.68 µM 0.863043551306228 0.146138506301995 no 514 0.194056761147516 949 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11
SGTC_2604 4'-hydroxychalcone 11.32 µM 0.862159102742938 0.146376804666772 no 515 0.194299985746531 914 5282362
SGTC_2311 7694451 200 µM 0.861847703055221 0.146460767637033 no 516 0.194385665263543 925 2163142
SGTC_877 0771-0151 33.1 µM 0.861630777633516 0.146519276530281 no 517 0.194445364415953 966 6166523
SGTC_3327 9140648 26.9345 µM 0.858607383498755 0.147336376257607 no 518 0.195278581585795 962 8029710
SGTC_1653 st012112 65 µM 0.856880132105192 0.147804549731319 no 519 0.195755566989918 932 720429
SGTC_1832 st054113 55 µM 0.856713505973916 0.147849766559236 no 520 0.195801618642087 957 1251267
SGTC_1312 1218-2183 165 µM 0.854838005629627 0.148359354168319 no 521 0.196320417426078 1006 6744073
SGTC_133 0724-0033 378.92 µM 0.852381090627479 0.14902869206841 no 522 0.197001305914534 924 280309
SGTC_299 1273-0059 1.44 µM 0.851431099769117 0.149288038251616 no 523 0.197264961017465 936 2848077
SGTC_749 1000-0129 128 µM 0.850537680497476 0.149532215272052 no 524 0.197513110228169 1028 708470
SGTC_2814 7977482 42.97 µM 0.84879970284846 0.15000797849397 no 525 0.197996377778423 1020 6456762
SGTC_1828 st055811 49 µM 0.848167599245517 0.150181263911197 no 526 0.198172319448222 942 5877589
SGTC_1755 st041960 45.185 µM 0.846432888076925 0.150657504384117 no 527 0.198655649030088 971 2257073
SGTC_2415 st077333 57.7 µM 0.845042308684316 0.151039993785327 no 528 0.199043608614258 1049 2766255
SGTC_49 0717-0965 32.132 µM 0.844187232651284 0.151275509492342 no 529 0.199282393907887 1072 5889349 YGL099W LSG1
SGTC_33 0986-0033 35.816 µM 0.843432395177091 0.151483619132029 no 530 0.199493330255743 952 2848082
SGTC_1466 k213-0079 57.5 µM 0.843385603475235 0.151496525925639 no 531 0.199506410433987 985 3657981
SGTC_255 tunicamycin 200.472 nM 0.841854454177004 0.151919274050593 no 532 0.199934713519928 980 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_2446 5162541 200 µM 0.841645685965526 0.15197697530685 no 533 0.199993154331647 925 1549321
SGTC_2228 7354201 200 µM 0.841082860070293 0.15213260676174 no 534 0.2001507582246 1026 753451
SGTC_324 1315-0088 19.6 µM 0.841018798255605 0.152150327708686 no 535 0.200168701702305 941 6787421
SGTC_1128 3448-9350 235 µM 0.838212008073705 0.152928095024588 no 536 0.200955822070816 880 619386
SGTC_777 1315-0167 517 µM 0.837618299840987 0.153092949973343 no 537 0.20112255587734 911 4221767
SGTC_2716 st080858 38.6235 µM 0.832126683901526 0.154623388927112 no 538 0.202668720769529 1025 5296050
SGTC_2249 haloperidol 116.36 µM 0.829940126379522 0.155235557589136 no 539 0.203286318190763 1078 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_2983 9022671 12.99 µM 0.82941989398841 0.155381441882721 no 540 0.203433424073962 969 6405161
SGTC_2080 5212524 12.4 µM 0.829039862664162 0.155488067961 no 541 0.203540925493331 982 260183
SGTC_3080 9117754 49.47 µM 0.827764809321386 0.155846164596658 no 542 0.203901853865857 1039 9550191
SGTC_1895 st058434 18.3 µM 0.822416492375303 0.157354149815298 no 543 0.205419948042751 1049 5393175
SGTC_2536 dehydroabietamide 32.04 µM 0.822004232311477 0.157470785489642 no 544 0.20553724407127 1035 3983547
SGTC_2795 7780010 54.55 µM 0.821013885353961 0.157751204312676 no 545 0.205819179545651 949 953673
SGTC_1604 st002052 72.4 µM 0.820284625773842 0.157957905259788 no 546 0.206026934359504 1003 6254834 YHR062C RPP1
SGTC_1929 genistein trimethyl ether 50.5 µM 0.81825869738473 0.158533066114727 no 547 0.206604742410069 1052 136420
SGTC_2391 6285546 200 µM 0.817866374161508 0.158644605182637 no 548 0.206716746384598 1035 846083
SGTC_1379 2144-0755 36.5 µM 0.816586352036584 0.159008878342952 no 549 0.207082428574181 1075 5392327
SGTC_806 3966-4455 5.86 µM 0.815487346101637 0.159322074213062 no 550 0.207396702422795 911 714982
SGTC_2320 7373003 200 µM 0.813647117652254 0.159847408342303 no 551 0.207923568573007 1044 5415828
SGTC_1690 st023502 41.2 µM 0.809458153562056 0.161047461763959 no 552 0.209125831852369 1012 24207482
SGTC_1004 4084-0029 199 µM 0.804296050788286 0.162534365600871 no 553 0.210613008955169 1062 716894 YLR208W SEC13
SGTC_1561 5-methoxyflavone 52.9 µM 0.80413991226607 0.162579478837076 no 554 0.210658088192085 1017 94525
SGTC_2479 5617353 43.85 µM 0.803414166529741 0.162789276098804 no 555 0.21086769478832 1014 2731746
SGTC_1845 st056753 3.01 µM 0.800015395966776 0.16377412841156 no 556 0.211850938529342 1049 5375839
SGTC_1596 piperlongumine 63 µM 0.796273408307415 0.164862897159522 no 557 0.212936569048301 1075 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_1751 st044839 27.194 µM 0.794245869786655 0.165454783458825 no 558 0.213526154839799 1067 5291326
SGTC_490 phenamil 164 µM 0.791256269039908 0.166330022981944 no 559 0.214397230925409 985 4755 Irreversibly blocks amiloride-sensitive Na+ channels.
SGTC_2809 7964133 12.99 µM 0.791119114419838 0.16637024815321 no 560 0.21443724300458 1022 1253665
SGTC_1234 0326-0494 15.5 µM 0.789533441397439 0.166835755761478 no 561 0.21490014614428 1059 1547813
SGTC_1433 4060-0023 7.6 µM 0.789441484975219 0.166862777252518 no 562 0.214927008638121 1052 3840627
SGTC_3287 9117173 37.0625 µM 0.786281891525382 0.167792941877163 no 563 0.215851179465173 1041 2789709
SGTC_2126 5251174 33.877 µM 0.785186578438598 0.168116173012962 no 564 0.216172091749758 1119 790722
SGTC_1088 bifonazole 369 nM 0.782103577206451 0.16902812799426 no 565 0.217076852312837 1019 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase.
SGTC_2201 6605497 169.863 µM 0.780804899317769 0.169413227566212 no 566 0.21745862603908 1066 670741
SGTC_1277 0873-0036 22 µM 0.780215483962561 0.16958819371284 no 567 0.217632024901475 1099 5965735
SGTC_110 0850-0284 111.64 µM 0.779964421793275 0.169662755943926 no 568 0.21770590857621 939 3906265
SGTC_1317 1273-0028 910 nM 0.779508280599571 0.16979827780382 no 569 0.217840180828411 1059 5917803 YLR359W | YHR072W ADE13 | ERG7
SGTC_2445 5742597 35.57 µM 0.778595808281383 0.170069586215169 no 570 0.218108924533958 1022 1774255
SGTC_790 1575-0012 79.1 µM 0.775591698720373 0.1709647698776 no 571 0.218995051684345 1115 378741 YLR208W SEC13
SGTC_715 0868-0130 184 µM 0.775346011351566 0.171038114470967 no 572 0.219067613974129 1082 2876258
SGTC_912 3474-0017 2.18 µM 0.774330445775833 0.171341502878356 no 573 0.21936770182354 1100 3360550
SGTC_222 nsc-310342 10.666 µM 0.773410502456846 0.171616622014533 no 574 0.219639738189474 1036 432556
SGTC_1756 st041558 35.5 µM 0.773395600380966 0.171621080965436 no 575 0.219644146475029 1168 3955792
SGTC_1997 st073024 93.8 µM 0.773278599502686 0.171656092161339 no 576 0.219678759074867 1084 686268
SGTC_2592 piperlongumine 83.33 µM 0.77106633454473 0.172318946200717 no 577 0.220333806974776 1044 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_2825 7998094 58.44 µM 0.770546019831715 0.172475083362535 no 578 0.22048803377175 1025 2987815
SGTC_2580 diallyl disulphide 81.36 µM 0.762879383013507 0.174786156941076 no 579 0.222767666413914 1051 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.
SGTC_1310 1188-0297 994 nM 0.760886010358447 0.175390255421626 no 580 0.223362577560117 1072 1588352
SGTC_2899 9053889 58.44 µM 0.760455701923222 0.175520835387162 no 581 0.223491119294222 1077 6470052
SGTC_2278 7948257 134.34 µM 0.75908919418913 0.175935919673958 no 582 0.223899601360781 1088 1247028
SGTC_2893 9048488 25.97 µM 0.757353131056199 0.176464154172834 no 583 0.224419163807708 1070 6467338
SGTC_2076 5212012 200 µM 0.757327622002675 0.176471923321674 no 584 0.22442680315887 1000 604802
SGTC_18 0111-0177 500 nM 0.75590423899969 0.176905777904162 no 585 0.224853306120618 1209 721752
SGTC_772 k072-0172 35.3 µM 0.75543262378745 0.17704967723723 no 586 0.2249947223465 1069 5861980
SGTC_1791 st048313 56.1 µM 0.754444522895217 0.177351406492119 no 587 0.225291172810315 1054 1204976
SGTC_1060 3448-7350 82 µM 0.754439488405962 0.177352944668714 no 588 0.225292683826175 1060 570178
SGTC_1644 st010134 20.9 µM 0.754054259842024 0.177470667697863 no 589 0.225408320611904 1091 3818134
SGTC_674 0498-0004 451 µM 0.753116506456252 0.177757444395002 no 590 0.225689953099523 1077 4231473
SGTC_287 k060-0039 29.6 µM 0.752302689295968 0.178006556650912 no 591 0.225934525481871 1125 5861974
SGTC_1467 k284-1082 293 µM 0.751218825158645 0.178338672853641 no 592 0.226260486294352 1110 3334705
SGTC_2832 7992762 51.95 µM 0.750411737862906 0.17858623291147 no 593 0.226503381839862 1010 2985177
SGTC_1119 parthenolide 318.541 nM 0.749301028315435 0.178927277513462 no 594 0.226837894079152 1166 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs.
SGTC_1061 3448-9325 110 µM 0.749130279506502 0.178979742449952 no 595 0.226889343177698 1098 723482
SGTC_2141 5621638 7.665 µM 0.748301157856219 0.179234639168316 no 596 0.227139263143117 1108 2856238
SGTC_1237 0330-0133 46.1 µM 0.748114549694917 0.179292039541189 no 597 0.227195533337858 1066 X1237 YHR072W ERG7
SGTC_2284 7945075 39.21 µM 0.748054545488015 0.179310499195461 no 598 0.22721362879457 1195 1245402
SGTC_1794 st048918 76.9 µM 0.747842415142193 0.179375768414355 no 599 0.227277607412064 1061 672303
SGTC_1925 st057770 10.1 µM 0.747357080456936 0.179525154548214 no 600 0.227424022769516 1077 5989122
SGTC_2941 9056145 11.23 µM 0.747191351625877 0.179576183827671 no 601 0.227474031869779 1037 2119517
SGTC_1779 st039427 55 µM 0.74578701187794 0.180008957499261 no 602 0.227898043515933 1179 1124498
SGTC_1392 3455-1037 33.9 µM 0.745419114012506 0.180122440301356 no 603 0.228009196208042 1112 981132
SGTC_99 0109-0120 622.8 µM 0.745312889492116 0.180155214967303 no 604 0.22804129541098 1118 759414
SGTC_3349 9149703 23.001 µM 0.744812462636689 0.180309667740805 no 605 0.228192549890267 1130 4910494
SGTC_2365 9042475 200 µM 0.743349881023513 0.180761558069951 no 606 0.228634939698859 1145 6464479
SGTC_2851 9015922 71.43 µM 0.742845357201055 0.180917604142002 no 607 0.228787655622127 1098 2996893
SGTC_1923 st058458 19.1 µM 0.739447444957633 0.18197075501155 no 608 0.229817670712542 1171 3534982
SGTC_1558 st069300 45.6 µM 0.739168669088076 0.182057328795911 no 609 0.229902291621578 1070 24208000
SGTC_2723 salbutamol 83.58 µM 0.738510103236702 0.182261948524346 no 610 0.23010226498156 1079 9884233 β2-adrenoceptor agonist
SGTC_2292 7671323 168.05 µM 0.737160896322917 0.182681602533716 no 611 0.230512255095639 1123 937504
SGTC_2686 alizarin 95.37 µM 0.735856451177021 0.183087907073606 no 612 0.230909031129434 1112 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1
SGTC_1351 1496-0003 46.5 µM 0.735310977373176 0.183257976596854 no 613 0.231075062133532 1155 3891978
SGTC_2371 9071574 200 µM 0.734326298511078 0.183565232186305 no 614 0.231374946751098 1118 45596039
SGTC_2896 9052656 71.43 µM 0.733901700627585 0.183697821165431 no 615 0.231504325267776 1137 6469436
SGTC_1152 3909-8331 15.9 µM 0.732600993355027 0.184104363643131 no 616 0.23190091253732 1121 16001939
SGTC_2158 5657123 3.6195 µM 0.731290584567453 0.184514504263743 no 617 0.232300840138505 1123 2858827
SGTC_1078 idebenone 36.1 µM 0.730199904116907 0.184856305800897 no 618 0.232634000581466 1156 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen.
SGTC_2928 9011484 9.79 µM 0.730032490637556 0.184908805281413 no 619 0.232685162389253 1121 2994751
SGTC_1281 0884-0031 11.8 µM 0.729748211858898 0.184997973974421 no 620 0.232772052730178 1175 1548255
SGTC_1464 k208-0027 110 µM 0.729180209402542 0.18517621724689 no 621 0.232945717735454 1131 X1464
SGTC_368 fentichlor 4.58 µM 0.728619540343939 0.185352263813077 no 622 0.233117211132548 1110 7329 A pesticide.
SGTC_1173 0443-0020 122 µM 0.728133095120461 0.185505088717218 no 623 0.233266058251855 1145 5331295
SGTC_1324 1418-0026 34.4 µM 0.725101262701497 0.186459351316026 no 624 0.234194954914988 1146 1372513
SGTC_810 3825-7150 143 µM 0.725097869346092 0.186460421067736 no 625 0.234195995721602 1201 22330411 YGL099W LSG1
SGTC_1294 1000-1494 117 µM 0.723992365485203 0.186809132321527 no 626 0.234535211059837 1142 712797 YDL207W GLE1
SGTC_316 k060-0003 58.6 µM 0.721988197500798 0.187442339289342 no 627 0.235150866955548 1182 6152314
SGTC_3299 9121982 43.1275 µM 0.719700112510467 0.188166868080326 no 628 0.235854828487137 1184 17594604 YPL160W CDC60
SGTC_1360 1598-0022 39.8 µM 0.719312258303877 0.188289854333464 no 629 0.235974272338891 1184 761525
SGTC_2525 harmine 47.85 µM 0.718059391892324 0.18868746951628 no 630 0.236360333618337 1112 5280953 A monoamine oxidase inhibitor
SGTC_51 1013-0126 23.419 µM 0.717771023445716 0.188779060614112 no 631 0.236449241369945 1191 1627850
SGTC_1203 3992-3522 103 µM 0.717767668377337 0.188780126406476 no 632 0.236450275889583 1242 5322312
SGTC_3096 9117468 49.47 µM 0.716950674769239 0.189039768183091 no 633 0.236702266199479 1071 41316311
SGTC_679 0422-0091 41.4 µM 0.716949867422945 0.189040024867676 no 634 0.236702515287245 1204 627384 YHR062C RPP1
SGTC_2190 6049624 200 µM 0.712814830734097 0.190357517751858 no 635 0.237980173566574 1107 2265554
SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM 0.712741504785904 0.190380931418443 no 636 0.238002864141905 1156 2374 Ca(2+)-ATPase inhibitor.
SGTC_2258 7960471 200 µM 0.712022532926654 0.190610599593946 no 637 0.238225411428714 1129 2974708
SGTC_2453 5731132 22.18 µM 0.711554690582414 0.190760138327811 no 638 0.23837028643083 1208 1362040
SGTC_1981 st071826 47 µM 0.71103957612681 0.190924870123108 no 639 0.238529855804969 1138 11838600
SGTC_1562 morin hydrate 59.1 µM 0.710214369998846 0.19118894995441 no 640 0.238785605525613 1172 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase.
SGTC_3202 9113761 49.47 µM 0.709450611880185 0.191433564830449 no 641 0.239022444745204 1197 4798415
SGTC_2567 aureobasidin a 60 nM 0.70743037579283 0.192081525825814 no 642 0.239649532865772 1202 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1
SGTC_1246 0422-0085 105 µM 0.707187314362715 0.192159574545019 no 643 0.239725040425087 1184 264295
SGTC_1900 st060200 72.8 µM 0.706358633755675 0.192425815465796 no 644 0.23998256940058 1197 688945
SGTC_453 enantio-paf c16 10 µM 0.705437225961594 0.192722112716994 no 645 0.240269092229989 1180 13871343 A lipid and platelet activating factor
SGTC_773 4358-1457 44.6 µM 0.704450441986672 0.193039741958533 no 646 0.240576151161026 1218 1186886
SGTC_1169 aniline yellow 25.8 µM 0.702244302186307 0.193751016690673 no 647 0.241263410813491 1149 6051 A DNA damaging agent.
SGTC_562 3772-2733 112 µM 0.701576491332805 0.193966638160676 no 648 0.241471658325706 1206 2876874 YIL048W NEO1
SGTC_173 1273-0061 2.693 µM 0.6986759330381 0.194904860414642 no 649 0.242377288878443 1158 2847414 YPL266W DIM1
SGTC_2985 9022375 71.43 µM 0.696981277726795 0.195454293068329 no 650 0.242907255309617 1238 4939335
SGTC_146 3448-8650 53.125 µM 0.695700156803367 0.195870275406954 no 651 0.243308313660214 1206 2891488 YIL048W NEO1
SGTC_801 0866-0028 10.1 µM 0.695647129220563 0.195887505131959 no 652 0.243324921797386 1227 6849771
SGTC_1333 1482-0047 286 µM 0.694494615422915 0.196262207143102 no 653 0.243686038227037 1189 3811116
SGTC_326 k292-0812 17.5 µM 0.694385011338117 0.196297863925541 no 654 0.243720395467561 1172 3579357
SGTC_1648 st011736 69.8 µM 0.693587406737387 0.196557461689377 no 655 0.243970496761295 1216 2855514
SGTC_2981 9013952 38.96 µM 0.69170557578676 0.197170768277434 no 656 0.244561122353482 1133 2996344
SGTC_102 gallobenzophenone 83.616 µM 0.691055206969106 0.197382998599792 no 657 0.244765424017866 1242 70837
SGTC_1055 3448-0672 86 µM 0.687924419720194 0.19840657841874 no 658 0.245750188905893 1179 748378
SGTC_1548 st061468 90.8 µM 0.687159551460827 0.198657130471675 no 659 0.245991095208489 1212 390799
SGTC_1185 1319-0113 81.3 µM 0.686104824748086 0.199002945838759 no 660 0.246323504339889 1212 4672763
SGTC_2721 ifenprodil 61.44 µM 0.685574894483328 0.199176831968901 no 661 0.24649060873308 1215 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor.
SGTC_1528 arabinosylhypoxanthine 74.6 µM 0.685233605313723 0.199288867692013 no 662 0.246598260549167 1251 804 An inhibitor of viral and cellular DNA polymerases.
SGTC_2718 lomofungin 53.02 µM 0.683722721105081 0.199785304581541 no 663 0.2470751365808 1236 5351222 A RNA synthesis inhibitor.
SGTC_740 k014-0057 261 µM 0.683425106031985 0.199883180706178 no 664 0.247169130093654 1218 4012779
SGTC_2755 lomerizine 42.69 µM 0.682910468977004 0.200052496483901 no 665 0.247331709128623 1228 3949 A calcium channel blocker.
SGTC_477 mead ethanolamide 10 µM 0.682581333429156 0.200160827389031 no 666 0.247435716330653 1101 16061185
SGTC_1033 k072-0102 21.3 µM 0.682370789534787 0.200230143801319 no 667 0.247502260693403 1195 5965931
SGTC_822 1487-0950 154 µM 0.68163643375152 0.200472025304184 no 668 0.247734435513117 1225 1958375
SGTC_1529 apigenin 74 µM 0.680285001959108 0.20091761718615 no 669 0.248162009598598 1275 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_2891 9063876 19.48 µM 0.67999067205916 0.201014741906221 no 670 0.24825518362285 1185 6472478
SGTC_2477 5967686 25.23 µM 0.679580582965564 0.201150112477019 no 671 0.248385033845254 1222 776118
SGTC_965 1291-5240 308 µM 0.679159137716405 0.201289288664682 no 672 0.248518517579961 1207 2834598
SGTC_359 0081-0058 15.9 µM 0.67850660476906 0.201504892069935 no 673 0.24872526876293 1308 3494159
SGTC_2307 7538926 6.34 µM 0.678325513153363 0.201564751070139 no 674 0.248782662796825 1226 96582
SGTC_2493 resveratrol 26.09 µM 0.678298337451963 0.201573734792399 no 675 0.248791276300581 1159 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase.
SGTC_2766 oltipraz 83.91 µM 0.677656166509768 0.201786092965662 no 676 0.248994862482531 1211 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40
SGTC_2232 chlorophetanol 41.5365 µM 0.676745428560064 0.202087492623353 no 677 0.249283743873678 1283 15907 An antifungal of unknown mechanism. YFR051C RET2
SGTC_1040 k898-0338 155 µM 0.676205177968569 0.202266410410927 no 678 0.249455192751296 1267 20969351
SGTC_942 3253-1115 227 µM 0.676015141830969 0.202329368253543 no 679 0.249515515738422 1264 46497897
SGTC_1883 5-benzylidenerhodanine 20 µM 0.675286548851836 0.202570855361552 no 680 0.249746864108668 1218 1273210
SGTC_869 0564-0080 44.1 µM 0.675212224090548 0.202595499470371 no 681 0.249770470671438 1213 6843321
SGTC_2771 fluoxetine 41.05 µM 0.675180390934085 0.202606055044263 no 682 0.249780581680563 1236 3386 A selective serotonin reuptake inhibitor.
SGTC_2166 5933061 31.504 µM 0.674301051012303 0.202897765789009 no 683 0.250059967995686 1419 2877375
SGTC_1571 st070080 73.4 µM 0.67339713680927 0.203197890098641 no 684 0.250347334837853 1270 4315245
SGTC_3223 9129970 49.47 µM 0.673265458699015 0.203241632945427 no 685 0.250389211736667 1277 17248386
SGTC_1208 2323-2347 50.3 µM 0.672291295157902 0.203565420030912 no 686 0.250699135167344 1237 5412760
SGTC_2457 5731572 11.68 µM 0.671803810680718 0.203727562850229 no 687 0.250854301235825 1265 2865357
SGTC_1426 4048-4480 71.7 µM 0.670582480702248 0.204134128891693 no 688 0.251243273096525 1227 14224343
SGTC_3103 9120822 49.47 µM 0.670510645914387 0.204158056865998 no 689 0.251266161124756 1301 17141819
SGTC_3214 9129694 49.47 µM 0.67030532241342 0.20422645878156 no 690 0.251331587457714 1207 17158655
SGTC_604 1000-0114 314 µM 0.669765631503526 0.204406317648763 no 691 0.251503602903955 1271 1572745
SGTC_2225 6654152 15.4 µM 0.669084104061494 0.204633580009557 no 692 0.25172091469486 1196 97582 YGR029W | YLR033W ERV1 | RSC58
SGTC_1212 0520-0165 585 µM 0.668943113219771 0.204680613620587 no 693 0.251765883399618 1378 5403258
SGTC_67 0335-0847 266 µM 0.668941334716168 0.20468120695868 no 694 0.251766450676343 1305 4552207 YOR254C SEC63
SGTC_1390 3413-2614 145 µM 0.668781513275695 0.204734530200562 no 695 0.251817430546854 1250 3421432
SGTC_223 busulfan 5 mM 0.667502021984842 0.205161720796723 no 696 0.252225759279437 1227 2478 A DNA alkylator.
SGTC_25 0118-0223 35.662 µM 0.666482433431157 0.205502515181538 no 697 0.252551394100595 1276 5333628
SGTC_2373 9071805 200 µM 0.665549652693926 0.205814588539774 no 698 0.252849498251974 1253 10149009
SGTC_2882 9058044 58.44 µM 0.663587140997105 0.206472088591183 no 699 0.253477294840232 1205 18076804
SGTC_3231 9132313 49.47 µM 0.663586908000576 0.206472166725787 no 700 0.253477369423125 1254 4905967
SGTC_827 3253-0474 693 µM 0.66292206633594 0.2066951904776 no 701 0.253690234199864 1248 5402065
SGTC_2288 7946289 167.31 µM 0.662703983975644 0.206768378121607 no 702 0.25376007886477 1280 1246052
SGTC_802 4112-3352 742 µM 0.662677855988478 0.206777147607782 no 703 0.253768447483831 1293 704594
SGTC_508 roscovitine 141 µM 0.662463654892418 0.206849049451807 no 704 0.253837060121321 1282 160355 A CDKinase inhibitor.
SGTC_3063 1327-0034 4 µM 0.661314472357159 0.207235053325448 no 705 0.254205331091526 1176 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_1182 1222-0449 220 µM 0.660362125251758 0.207555263860959 no 706 0.254510735672253 1238 658318
SGTC_1893 st059353 36.1 µM 0.659855166641063 0.207725839266012 no 707 0.254673388674825 1217 3112488
SGTC_162 k030-0015 37.8 µM 0.659751409482575 0.207760760446755 no 708 0.25470668491328 1298 1809920 YMR134W ERG29
SGTC_32 0928-0142 34.1 µM 0.657468268029181 0.208530066621675 no 709 0.255439934018823 1224 2244242
SGTC_3020 9089140 49.47 µM 0.657078593491978 0.208661535335631 no 710 0.255565191209954 1261 17217859
SGTC_1833 st055984 71 µM 0.655993291774801 0.209027952744759 no 711 0.255914220213879 1263 676288
SGTC_1888 azatryptophan 97.5 µM 0.655992564946478 0.209028198262001 no 712 0.255914454042489 1225 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides
SGTC_1994 st072947 40.9 µM 0.655204080858143 0.209294642381182 no 713 0.256168183633616 1277 5286565 YDL195W SEC31
SGTC_328 k915-0120 63.5 µM 0.653621616416356 0.209829990700144 no 714 0.256677807024167 1239 6624543
SGTC_1135 dihydrocapsaicin 536.708 nM 0.652962096962514 0.210053343816079 no 715 0.256890357140257 1220 107982 A Capsaicinoid.
SGTC_2807 7945238 51.95 µM 0.651152636745303 0.210666853211323 no 716 0.257473980498814 1291 17148797
SGTC_1339 1486-1321 22.7 µM 0.648066483761383 0.21171565581698 no 717 0.258470975296773 1279 3469382
SGTC_3042 9091578 49.47 µM 0.647887715588915 0.211776502133468 no 718 0.25852878832463 1233 25236497
SGTC_1991 st073000 8.92 µM 0.647410292101129 0.21193905022472 no 719 0.258683218299618 1339 4301969 YIL048W NEO1
SGTC_462 ag-879 158 µM 0.646555129481269 0.212230389295355 no 720 0.258959953137725 1272 6809654 Ag-879 is a 5-Lipoxygenase inhibitor.
SGTC_763 3453-1109 128 µM 0.646102205848344 0.212384787299757 no 721 0.259106583462076 1281 1560353
SGTC_113 0099-0221 2.5 µM 0.645115090490576 0.21272151425304 no 722 0.259426302655372 1331 89219
SGTC_1417 3966-0327 90.4 µM 0.644944792534084 0.212779638174959 no 723 0.259481481478545 1315 651118
SGTC_2750 bromebric acid 70.15 µM 0.639405951476059 0.214675133708017 no 724 0.261279439152292 1322 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2
SGTC_108 0509-0257 621.132 µM 0.63933681370431 0.214698855795728 no 725 0.261301922271948 1272 536624
SGTC_1942 st076330 65.2 µM 0.639040091967574 0.214800682260787 no 726 0.26139842538928 1320 24208414
SGTC_3320 9137005 35.139 µM 0.638594070147236 0.214953797044496 no 727 0.26154351995478 1270 4908713
SGTC_2159 5658611 73.75 µM 0.637569199052465 0.215305865001922 no 728 0.261877075524429 1296 793844
SGTC_2182 6325192 200 µM 0.637548501527235 0.215312978546736 no 729 0.261883814008349 1234 736248
SGTC_2436 5633522 8.09 µM 0.637499135961069 0.215329945578205 no 730 0.261899886292335 1274 5724242
SGTC_1263 0774-1208 64.8 µM 0.637392486682663 0.21536660377019 no 731 0.261934610551853 1322 906585
SGTC_1815 st051655 58.2 µM 0.63705975273076 0.215480996542272 no 732 0.262042961570313 1254 5984156
SGTC_1352 1496-0991 99 µM 0.636721634981146 0.215597276340311 no 733 0.262153089291337 1283 3000039
SGTC_213 1246-0773 967 nM 0.636617062273011 0.215633246601671 no 734 0.26218715428022 1280 6251622
SGTC_1799 st045822 46.1415 µM 0.635636944642854 0.215970550394681 no 735 0.2625065418303 1259 3674992
SGTC_1375 2910-0797 186 µM 0.635578830539434 0.215990559739822 no 736 0.26252548552517 1286 742508
SGTC_1413 3910-0535 34.4 µM 0.635561683478441 0.215996463872652 no 737 0.262531075157316 1318 2876951
SGTC_2242 6630449 61.2675 µM 0.634101931291615 0.216499433264082 no 738 0.263007151234369 1307 691249 YDR170C SEC7
SGTC_2655 perillic acid 100 µM 0.633863966318635 0.21658149020986 no 739 0.263084801717088 1278 5702197 An apoptosis inducer.
SGTC_571 k831-0106 44.2 µM 0.632971500393158 0.216889397528935 no 740 0.263376127091787 1295 4783639
SGTC_519 k048-0011 62.8 µM 0.632919998319507 0.216907173843227 no 741 0.263392943807553 1300 6836379
SGTC_778 3456-2434 196 µM 0.629150700733208 0.21821045890503 no 742 0.264625200221718 1336 5539063
SGTC_2334 9017922 200 µM 0.627267471469304 0.218863297420932 no 743 0.265241961058014 1334 3163164
SGTC_80 0159-0065 512.242 µM 0.62546976575361 0.219487535435532 no 744 0.265831392898245 1263 1548079
SGTC_2843 9000894 45.46 µM 0.624974490634558 0.219659695044899 no 745 0.265993900293503 1180 2242070
SGTC_3225 9130819 49.47 µM 0.624146832186619 0.219947565417974 no 746 0.266265580049851 1333 4547121
SGTC_911 3456-4043 236 µM 0.62381166277863 0.220064203253023 no 747 0.266375639702189 1382 914281
SGTC_1876 myriocin 605 nM 0.622810099398839 0.220412955323313 no 748 0.266704660397334 1380 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1
SGTC_1255 0566-0045 221 µM 0.621587341431421 0.22083915819507 no 749 0.267106623387515 1354 2788469
SGTC_2791 5663188 71.43 µM 0.621451381345773 0.220886577393233 no 750 0.267151337075015 1316 54690634
SGTC_2765 myclobutanil 7.74 µM 0.620691869882107 0.221151581649303 no 751 0.267401189860306 1325 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11
SGTC_1218 1348-1416 30.7 µM 0.619346220677485 0.221621543977184 no 752 0.267844150744093 1302 6787668
SGTC_1086 cerivastatin 2.18 µM 0.619182086393366 0.221678906213124 no 753 0.267898205758786 1290 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7
SGTC_1468 k284-1086 134 µM 0.618497815852481 0.221918138913001 no 754 0.268123618556827 1326 15996457
SGTC_2343 7990716 14.84 µM 0.618181231298088 0.222028872161299 no 755 0.268227940313926 1310 6456862
SGTC_3249 9135183 49.47 µM 0.617431119260849 0.222291368207105 no 756 0.268475200655386 1335 4902779
SGTC_52 0329-0193 875 nM 0.615466184519378 0.222979821034016 no 757 0.269123447275245 1382 3739292
SGTC_1729 st035615 45.989 µM 0.612819380749368 0.223909096702649 no 758 0.269997887267632 1315 17385451
SGTC_377 3970-0964 33.1 µM 0.611906426612242 0.224230138735686 no 759 0.270299834697326 1343 16481235
SGTC_2074 5212007 75.395 µM 0.6102267782441 0.224821472476419 no 760 0.270855796695135 1260 758611
SGTC_224 benfluorex 43.875 µM 0.610073850210196 0.224875355903409 no 761 0.270906444060218 1338 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis.
SGTC_1250 0485-0349 40.2 µM 0.609359421269364 0.225127178332648 no 762 0.271143114306151 1326 6842794 YDL195W SEC31
SGTC_916 4466-0038 42 nM 0.608209611251879 0.225532799479893 no 763 0.271524230440799 1370 5722064 YGL116W CDC20
SGTC_1654 st012436 41.8 µM 0.607138357940648 0.22591107991568 no 764 0.271879548084986 1303 4323132
SGTC_1621 st003705 32.4 µM 0.606325302297801 0.226198425035623 no 765 0.272149380003504 1348 24207032
SGTC_607 4491-0986 66.8 µM 0.606198208994666 0.226243360224532 no 766 0.272191570976802 1379 698981 YDR232W HEM1
SGTC_2065 5221596 34.26 µM 0.604998987952333 0.226667605797316 no 767 0.272589834574258 1349 788581
SGTC_1034 k072-0165 12.7 µM 0.602394588673012 0.227590502491854 no 768 0.273455755596192 1353 5835461
SGTC_938 3126-1755 342 µM 0.599861589148656 0.228490123942842 no 769 0.274299241566086 1350 1777771
SGTC_1129 3453-1384 223 µM 0.59985309630713 0.228493143621435 no 770 0.274302071832046 1414 1084452
SGTC_863 0466-0191 129 µM 0.599696833527526 0.228548707751389 no 771 0.274354149464476 1335 765160 YPR165W RHO1
SGTC_2469 5655019 90.81 µM 0.598890665114307 0.22883548675306 no 772 0.274622898400523 1442 2788239
SGTC_2451 5856223 45.7 µM 0.598742792356433 0.228888111573374 no 773 0.274672208202718 1315 2179896
SGTC_321 4534-3890 65.3 µM 0.598598621817156 0.228939425389913 no 774 0.274720287662669 1362 699746
SGTC_1520 flindersine 88 µM 0.598001752332597 0.229151934490157 no 775 0.274919381920694 1485 68230 Flindersine is a natural alkaloid of the quinoline subtype.
SGTC_3025 9087895 49.47 µM 0.597668578914427 0.229270605477098 no 776 0.275030547539533 1343 17173641
SGTC_3312 9133330 71.43 µM 0.595828724142302 0.229926552173354 no 777 0.275644826291603 1395 17617324
SGTC_111 0083-0039 52.457 µM 0.595142343336613 0.230171530062623 no 778 0.275874163289358 1265 759313
SGTC_1497 4476-2978 41.3 µM 0.592564771613149 0.231092800132482 no 779 0.276736230558435 1363 1528379
SGTC_345 1362-0200 395 µM 0.590667278424862 0.231772310992686 no 780 0.277371688259408 1329 1419823
SGTC_1960 st011366 51.8 µM 0.590130972653662 0.231964568909285 no 781 0.277551422687574 1349 3972846
SGTC_959 1222-0044 107 µM 0.589504495590072 0.232189264352882 no 782 0.277761448647057 1354 6083612
SGTC_2806 7952793 58.44 µM 0.589210881001706 0.232294615325708 no 783 0.277859909418115 1393 2972490
SGTC_917 harmaline 728.087 nM 0.588508412018666 0.232546774017937 no 784 0.27809554462125 1382 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7
SGTC_883 0850-0245 24.6 µM 0.5869882659102 0.233092967253152 no 785 0.278605793743782 1435 6823229 YPR165W RHO1
SGTC_2799 7812892 81.82 µM 0.586447183703957 0.233287551526834 no 786 0.278787522247259 1390 20205235
SGTC_507 nimesulide 162 µM 0.58444235681603 0.23400931365229 no 787 0.279461368223593 1408 4495 A COX2 inhibitor.
SGTC_2910 7948405 25.97 µM 0.582848228615981 0.234584100908528 no 788 0.279997737442875 1395 2971328
SGTC_2713 st079149 53.4 µM 0.582480401953386 0.234716837215188 no 789 0.280121569270041 1383 3103253
SGTC_2656 pseudo-anisatin 100 µM 0.582037415661107 0.234876751218382 no 790 0.280270739415394 1367 6708809 A neurotoxin.
SGTC_2426 5582046 32.21 µM 0.581064393949874 0.235228214455606 no 791 0.280598527432091 1408 2251934
SGTC_1649 st011737 51.3 µM 0.578597954654295 0.236120411708462 no 792 0.281430242580088 1356 1761035
SGTC_887 0885-0007 9.62 µM 0.57843399088244 0.236179789143502 no 793 0.281485575421017 1413 5719458
SGTC_3062 9077494 49.47 µM 0.577355886351049 0.236570416005996 no 794 0.281849533927937 1388 16459633
SGTC_669 0108-0021 26.2 µM 0.577079634741132 0.236670566732083 no 795 0.281942830500704 1582 17201
SGTC_53 0973-0023 39.979 µM 0.576635465093298 0.236831642417205 no 796 0.282092868069898 1364 674768
SGTC_2272 7805186 180 µM 0.576351959025769 0.236934485845033 no 797 0.282188654640131 1350 2956062 YPR165W RHO1
SGTC_1563 conessine 56.1 µM 0.574435881246571 0.237630197125341 no 798 0.282836438981922 1433 441082 An anti-amoebic, histamine inhibitor.
SGTC_2875 9039966 71.43 µM 0.573956544111412 0.237804415413563 no 799 0.282998604089066 1488 6463691
SGTC_920 mycophenolic acid 780.421 nM 0.573770078690128 0.237872206439523 no 800 0.283061699480373 1381 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_2398 5228213 48.84 µM 0.573411419560538 0.238002629683248 no 801 0.283183080039539 1429 80771 YMR134W ERG29
SGTC_1066 ketoconazole 628 nM 0.571378563274918 0.238742600248404 no 802 0.283871528500421 1443 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W
SGTC_280 3448-3607 3.04 µM 0.56982474455263 0.239309046212861 no 803 0.28439828539791 1375 626179
SGTC_933 2914-0560 114 µM 0.569559760802625 0.239405719494753 no 804 0.284488163590396 1451 463887
SGTC_3318 9139014 38.6185 µM 0.569418276201349 0.239457345659869 no 805 0.284536158429257 1381 16643984
SGTC_2102 5377816 72.7585 µM 0.569076433333847 0.239582105423217 no 806 0.284652135368044 1437 1379702
SGTC_2380 9035439 200 µM 0.568688406404763 0.239723763615541 no 807 0.284783808502938 1457 6462575
SGTC_3150 9097574 49.47 µM 0.567488783833092 0.240162002475212 no 808 0.28519107239669 1405 17217476
SGTC_257 daunorubicin 18.5 µM 0.566996223515229 0.240342068003342 no 809 0.285358373693085 1486 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_1628 st004252 77.7 µM 0.566590607317191 0.240490404528994 no 810 0.285496178943799 1471 692968
SGTC_3345 9148410 3.559 µM 0.566018752422622 0.240699620310388 no 811 0.285690516424835 1390 4903596
SGTC_398 bronopol 33.3 µM 0.565053622049178 0.241052942321719 no 812 0.286018646153722 1389 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them.
SGTC_2181 6316240 54.2555 µM 0.564039903362943 0.241424355356151 no 813 0.286363487908463 1358 12779990
SGTC_1434 4073-0095 163 µM 0.563321824087267 0.241687638022761 no 814 0.286607879877986 1385 24133745
SGTC_2262 9014885 67.46 µM 0.563280490997388 0.241702797479204 no 815 0.286621950242199 1353 6457424
SGTC_1922 5578187 25 µM 0.562454827589005 0.242005728539736 no 816 0.286903086271157 1476 1350412
SGTC_1030 k029-0042 36.7 µM 0.562317774017712 0.242056032610846 no 817 0.286949765261195 1444 6080581
SGTC_786 4544-0069 423 µM 0.561133963115891 0.242490773868703 no 818 0.287353108352322 1449 748821 YLR208W SEC13
SGTC_3176 9106582 49.47 µM 0.559747924941658 0.243000317823738 no 819 0.287825694053257 1323 17018027
SGTC_595 3909-8003 73.7 µM 0.559688082464854 0.243022330521298 no 820 0.287846106300344 1421 699517
SGTC_1272 0839-0021 27 µM 0.558156931244046 0.243585922021262 no 821 0.288368613821684 1399 5027250
SGTC_622 1348-1566 26.3 µM 0.55773326986549 0.243741989367555 no 822 0.288513267808768 1466 7340407
SGTC_2998 9066762 71.4286 µM 0.557348752328905 0.243883683716499 no 823 0.288644586203666 1492 4945196
SGTC_3148 9097893 49.47 µM 0.556038406456629 0.244366878582442 no 824 0.289092299897897 1294 17174100
SGTC_1892 st058411 7.36 µM 0.555157130258878 0.244692142373322 no 825 0.289393594366024 1466 3934738
SGTC_2847 9005661 71.43 µM 0.555072096729339 0.244723539104239 no 826 0.289422673794338 1328 2991449
SGTC_1508 1080-0625 72.9 µM 0.554999613948966 0.244750303463732 no 827 0.289447462251005 1375 767111
SGTC_2243 6634756 200 µM 0.554349251312744 0.244990521187963 no 828 0.289669925007418 1485 885676
SGTC_412 gemfibrozil 100 µM 0.553368637908945 0.245352959908217 no 829 0.290005504837546 1385 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels.
SGTC_2999 9069765 71.4286 µM 0.553188371628642 0.245419618406342 no 830 0.290067214344755 1445 2097066
SGTC_2231 micatex 6.853 µM 0.55276388997076 0.245576620801058 no 831 0.290212548986435 1429 20737 An antifungal of unknown mechanism.
SGTC_2429 5902844 64.44 µM 0.552029271008737 0.245848460643147 no 832 0.290464149459707 1454 1927790 YGL093W | YPR107C SPC105 | YTH1
SGTC_2138 5575593 77.673 µM 0.551750112805701 0.245951803225939 no 833 0.290559785429811 1382 762213
SGTC_83 0170-0301 39.027 µM 0.551208771260174 0.24615227081751 no 834 0.290745283981248 1394 3089716
SGTC_2015 5119600 184 µM 0.550788077366323 0.246308121108691 no 835 0.290889479090246 1487 2828786
SGTC_357 1325-0123 420 µM 0.549862193904443 0.246651310202288 no 836 0.291206948332885 1417 1098503
SGTC_565 1418-0001 44.5 µM 0.54965232564812 0.246729135814342 no 837 0.291278930969095 1451 2862145
SGTC_3160 9100216 49.47 µM 0.549099186263231 0.246934319913336 no 838 0.291468691823676 1375 17191039
SGTC_81 0411-0046 9.971 µM 0.548164179333948 0.247281363270831 no 839 0.291789587803399 1319 12925265
SGTC_1496 4469-0713 57.4 µM 0.545267390503028 0.248358207924749 no 840 0.292784814204136 1456 746691
SGTC_968 1309-0633 340 µM 0.54432591410094 0.248708727349709 no 841 0.293108608695379 1414 3761976
SGTC_1178 0988-0033 191 µM 0.543032294836181 0.249190781821033 no 842 0.293553783548733 1428 5392207
SGTC_420 mitomycin C 81.9 mM 0.542966924382692 0.249215154658935 no 843 0.293576287874646 1388 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_3093 9117344 49.47 µM 0.541479000980626 0.249770257355609 no 844 0.294088733837951 1415 24824913
SGTC_1540 guanosine 70.6 µM 0.541087607396337 0.249916384363129 no 845 0.294223599787352 1387 6802 Guanosine is a purine nucleoside
SGTC_1972 st070201 17.4 µM 0.540641513932179 0.250082988914511 no 846 0.294377348989193 1462 2829099
SGTC_11 0438-0307 1.3 µM 0.540522581536285 0.250127417082819 no 847 0.294418346125626 1489 4011476
SGTC_2024 5144227 134 µM 0.538953311108342 0.250714022731026 no 848 0.294959535338097 1465 3475211
SGTC_1132 3456-3614 2.5 µM 0.537612536184777 0.251215791515877 no 849 0.295422286835632 1621 3125502
SGTC_305 1682-2595 20.8 µM 0.534279374710751 0.252465484345219 no 850 0.296574129928018 1451 226033
SGTC_1162 k048-0130 20.1 µM 0.53344233060298 0.252779828793683 no 851 0.296863710770734 1420 6797406
SGTC_734 2023-0417 80 µM 0.533421128132046 0.252787793867661 no 852 0.29687104758328 1462 3935732
SGTC_350 k064-0020 19.8 µM 0.533097249559036 0.252909480865112 no 853 0.296983131455854 1507 2790705
SGTC_2669 eugenol 100 µM 0.530046018400931 0.254057394889811 no 854 0.298040012495236 1454 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism.
SGTC_2863 9028737 58.44 µM 0.530009851769945 0.254071017632895 no 855 0.298052550113155 1486 6460917
SGTC_1118 chelidonine 707.474 nM 0.52966958211056 0.254199204430993 no 856 0.298170520639862 1525 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor.
SGTC_7 0192-1582 4.227 µM 0.528841886344219 0.254511156508752 no 857 0.298457569166851 1470 252616
SGTC_1010 4112-3296 15.2 µM 0.52738555912236 0.255060521414724 no 858 0.298962934851276 1510 704384
SGTC_570 0987-0065 62.6 µM 0.526212225520157 0.255503584477824 no 859 0.299370380317273 1374 3104428
SGTC_1977 st070720 65.3 µM 0.525121415175882 0.255915846273121 no 860 0.29974939493064 1433 682188
SGTC_1619 st003326 88.7 µM 0.525119633192842 0.255916520041197 no 861 0.299750014278927 1504 2849032
SGTC_3152 9099253 49.47 µM 0.524843710037106 0.256020857798131 no 862 0.299845921472708 1456 25236131
SGTC_2246 7293507 91.5585 µM 0.52362567217462 0.256481712470356 no 863 0.300269461044604 1566 887656
SGTC_728 3030-5151 22.5 µM 0.522998650276114 0.256719119772057 no 864 0.300487596257187 1484 3125388
SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM 0.522873132178368 0.2567666580288 no 865 0.300531271457676 1513 5024745
SGTC_3314 9135860 59.4275 µM 0.522033278030646 0.257084859129722 no 866 0.300823580326381 1451 25252478
SGTC_737 1950-0117 57.9 µM 0.52120731830128 0.257397995864159 no 867 0.301111178304867 1455 5393513
SGTC_2970 9090938 41.86 µM 0.519926870245131 0.257883829067034 no 868 0.30155727320355 1560 17217104
SGTC_2418 pentamidine 31.67 µM 0.519605615888163 0.258005795421015 no 869 0.301669241547563 1395 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_676 falcarinol 140 µM 0.519304054761809 0.258120312328109 no 870 0.301774363122561 1565 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer.
SGTC_2741 miltefosine 3.04 µM 0.519284552240614 0.25812771925759 no 871 0.301781162097994 1424 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis.
SGTC_2968 9090663 33.37 µM 0.514511901126625 0.259943648742809 no 872 0.303447070934919 1464 25236811
SGTC_2724 maprotiline 69.64 µM 0.514084330624526 0.260106654554559 no 873 0.303596516076145 1501 4011 A tricyclic antidepressant.
SGTC_60 0986-0278 202 µM 0.513643351554329 0.260274827395527 no 874 0.303750682216088 1290 3110598
SGTC_2524 avocatin b 10.57 µM 0.513135184321917 0.260468692733757 no 875 0.303928380624713 1483 6710748
SGTC_3071 9117417 49.47 µM 0.512404615903334 0.260747534167211 no 876 0.304183930565093 1487 45595590 YGL055W OLE1
SGTC_1236 0330-0013 258 µM 0.512106530905301 0.260861350570759 no 877 0.304288227007476 1446 4617066
SGTC_1555 citronellol 128 µM 0.512048615458125 0.260883467120169 no 878 0.304308492790241 1515 8842 A terpine precursor.
SGTC_1829 berberine 14.4 µM 0.51193549239314 0.26092666894405 no 879 0.304348078565043 1554 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_766 1391-0721 126 µM 0.511294536906731 0.261171520017642 no 880 0.304572414918395 1567 1020919 YIL115C NUP159
SGTC_2279 7948423 32.93 µM 0.510602934966445 0.261435850897489 no 881 0.304814560157082 1609 1247112
SGTC_3060 1327-0027 12.5 µM 0.50921433513456 0.261966989505902 no 882 0.305300998035446 1457 16000455 YPR107C YTH1
SGTC_2161 5662504 8.5105 µM 0.507569764720493 0.262596751557588 no 883 0.305877549512239 1446 2859334
SGTC_848 0368-0089 85.6 µM 0.506899896400836 0.262853488839786 no 884 0.306112529187343 1450 762535
SGTC_964 1287-0107 19.4 µM 0.506598660829981 0.262968983805509 no 885 0.306218224086543 1576 51516812 YPR165W RHO1
SGTC_567 1080-0542 68.4 µM 0.502101451191982 0.264696311697542 no 886 0.307798079722082 1502 5950415
SGTC_303 1348-1668 34.2 µM 0.501882022655264 0.264780739140763 no 887 0.307875255852658 1484 5380509
SGTC_3027 9089541 49.47 µM 0.501110413013433 0.265077732768962 no 888 0.308146709391431 1458 9943819
SGTC_415 dibenzyl ketone 100 µM 0.500065150605464 0.26548032543251 no 889 0.308514601830392 1588 7593
SGTC_428 3448-4153 16.5 µM 0.499644328168052 0.265642496702858 no 890 0.308662769578024 1410 3834874
SGTC_815 1582-0027 36.9 µM 0.498521496064221 0.266075445350225 no 891 0.309058260956333 1539 3128206
SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM 0.494836929164936 0.267498669705039 no 892 0.310357617153123 1664 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis.
SGTC_1189 1431-2119 7.28 µM 0.492423566959706 0.268432946604077 no 893 0.311209971237496 1496 3107275
SGTC_416 estradiol valerate 100 µM 0.491755846047573 0.268691728663336 no 894 0.311445976853914 1498 13791 A steroid.
SGTC_1625 st003711 30.1 µM 0.491372998933165 0.268840161489637 no 895 0.311581328936393 1563 24207034 YER133W GLC7
SGTC_1955 wogonin 32.4 µM 0.491137835236 0.268931356709324 no 896 0.311664481528413 1574 5281703 A flavanone.
SGTC_2353 9059630 146.67 µM 0.489751147810811 0.26946942226374 no 897 0.312155001767778 1559 4779114
SGTC_611 3453-1652 23.7 µM 0.489528105198635 0.269556018105487 no 898 0.312233930934185 1555 1560575
SGTC_1239 0337-0584 35.4 µM 0.489176382352118 0.269692602114258 no 899 0.312358414306495 1645 914301 YML130C ERO1
SGTC_3260 9137109 49.47 µM 0.488831784259125 0.269826452988526 no 900 0.31248039682657 1543 17478346
SGTC_788 1182-0090 188 µM 0.487788926349311 0.270231728694215 no 901 0.312849677927165 1656 5715185
SGTC_1872 amphotericin b 148 nM 0.486885837426268 0.270582933102719 no 902 0.31316961796699 1559 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1
SGTC_2006 4011487 200 µM 0.485689804038466 0.271048412044479 no 903 0.313593556870491 1619 45595294
SGTC_1098 clofazimine 15.1 µM 0.482740093454475 0.272198101377633 no 904 0.314640145749828 1552 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2
SGTC_3271 9137798 49.47 µM 0.481719844236624 0.272596320599497 no 905 0.315002488566017 1578 6498326
SGTC_1410 3909-8106 77.9 µM 0.481532234893462 0.272669578925574 no 906 0.31506913766205 1569 1039210
SGTC_2830 7992007 71.43 µM 0.480851562083804 0.272935452333034 no 907 0.315311000399678 1515 1952075
SGTC_406 estrone 100 µM 0.480659522284663 0.273010487058239 no 908 0.315379252018835 1618 5870 A steroid.
SGTC_1677 st019204 53.9 µM 0.479896516889801 0.273308713236625 no 909 0.315650489041753 1455 3945625
SGTC_2979 9012552 45.46 µM 0.47829469587618 0.273935321021195 no 910 0.316220235515484 1548 17100905
SGTC_2570 licareol 100 µM 0.477495482093936 0.274248226509837 no 911 0.316504668610913 1483 443158
SGTC_1656 st012921 11 µM 0.477440750916097 0.27426966113198 no 912 0.316524150925141 1545 6732821
SGTC_671 0560-0003 407 µM 0.474255026511263 0.275518724491677 no 913 0.317659029019022 1554 3238678
SGTC_2935 9038016 29.96 µM 0.474194901681923 0.275542325193796 no 914 0.317680464331939 1507 6463195
SGTC_1295 1013-0063 9.78 µM 0.473562761090555 0.275790518479888 no 915 0.317905867961576 1608 6826038
SGTC_1882 5615643 20 µM 0.472680871263226 0.276136952636299 no 916 0.318220437906263 1465 2253075
SGTC_1641 st009299 47.1 µM 0.472253145259151 0.276305053803197 no 917 0.31837305494016 1508 4046054
SGTC_1793 st048256 72.231 µM 0.472201494480857 0.276325356541306 no 918 0.318391486555404 1482 672022
SGTC_2259 7964009 200 µM 0.471731023392267 0.276510321638706 no 919 0.31855939517387 1551 313134
SGTC_2411 st077133 39.94 µM 0.471182404297653 0.276726087159874 no 920 0.318755241465366 1664 1403142 YNL221C POP1
SGTC_2254 7938975 95.19 µM 0.469155195549552 0.277524079654263 no 921 0.319479354212338 1622 2969277
SGTC_1928 4'-methoxychalcone 40.3 µM 0.468148603619457 0.27792073291907 no 922 0.31983916190788 1694 641818
SGTC_270 tamoxifen 5.46 µM 0.468100585028664 0.277939661829929 no 923 0.319856330460819 1646 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen. YIL048W NEO1
SGTC_2967 9089538 49.85 µM 0.4636002082485 0.279716496056857 no 924 0.32146710256558 1704 728216
SGTC_506 n9-isopropylolomoucine 153 µM 0.463365570201616 0.279809286585215 no 925 0.321551176566256 1677 6610355
SGTC_945 3381-0768 11.3 µM 0.462719157227593 0.28006499582666 no 926 0.321782842389455 1553 1126236 YIL048W NEO1
SGTC_451 chloral hydrate 100 µM 0.462634259693512 0.280098588163478 no 927 0.321813273688305 1561 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1
SGTC_1745 st081495 74 µM 0.462300914329768 0.280230505456365 no 928 0.321932772019877 1557 13842402 YBL026W LSM2
SGTC_1954 st077032 68.9 µM 0.461659630829607 0.280484370059882 no 929 0.322162712433528 1448 698907
SGTC_2397 5161689 200 µM 0.46109081149447 0.280709641428184 no 930 0.322366726874334 1607 2259942
SGTC_1363 1636-0063 10.4 µM 0.460979760462534 0.280753631536956 no 931 0.322406563014385 1546 6072185
SGTC_2879 9041815 71.43 µM 0.460311229086576 0.281018524064014 no 932 0.322646421149888 1505 4942971
SGTC_1219 1469-0211 33.1 µM 0.460027595814012 0.281130944694599 no 933 0.322748206443487 1572 6822282
SGTC_3316 9136639 10.545 µM 0.4592690150421 0.281431721787931 no 934 0.323020497743093 1618 4903665
SGTC_1973 st070275 50.2 µM 0.458951980578342 0.281557471869021 no 935 0.323134324853897 1525 17118334
SGTC_1968 st069590 43.6 µM 0.458866035459781 0.281591566224749 no 936 0.323165185187714 1607 6384066
SGTC_2698 st077697 67.5 µM 0.458806821898392 0.281615057352824 no 937 0.32318644772318 1490 3154499
SGTC_3101 9120531 49.47 µM 0.456248243772525 0.282630994773574 no 938 0.324105738513859 1611 24824904
SGTC_3295 9122362 53.5725 µM 0.455492402024229 0.282931454389509 no 939 0.324377516253586 1534 4730473
SGTC_3106 9121286 49.47 µM 0.453080104461775 0.283891407127151 no 940 0.325245530556193 1598 15943471
SGTC_1079 idarubicin 2.36 µM 0.453013193134931 0.283918056109597 no 941 0.325269620731567 1556 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_443 clozapine 122 µM 0.452470985079258 0.284134047146036 no 942 0.325464859556372 1581 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_1885 st057546 99.9 µM 0.45179323793766 0.284404141244597 no 943 0.325708970790582 1615 702008
SGTC_697 0508-1955 564 µM 0.451691609248654 0.284444652630552 no 944 0.325745581899811 1651 6243113
SGTC_1924 st058459 75.1 µM 0.450811835360766 0.284795464646656 no 945 0.326062585240269 1541 688683
SGTC_861 0443-0273 110 µM 0.45026916729293 0.285011957784789 no 946 0.326258184099464 1577 6149169
SGTC_1421 4029-0249 71.4 µM 0.449342854056701 0.285381684330395 no 947 0.326592174135455 1659 2894095
SGTC_850 0388-0143 75.9 µM 0.448468896206551 0.285730723149462 no 948 0.326907414480219 1530 67273
SGTC_717 1532-0246 73.2 µM 0.447705969478309 0.286035584586288 no 949 0.327182706457285 1533 9561992
SGTC_1494 4358-1428 177 µM 0.447539939037982 0.286101949935214 no 950 0.327242628801347 1677 1564571
SGTC_1338 1486-1223 76 µM 0.447339441349405 0.286182102212152 no 951 0.327314996716888 1623 3444526
SGTC_100 0086-0128 49.5915 µM 0.445883925200271 0.28676428844998 no 952 0.327840547202189 1460 93297
SGTC_3006 9075424 71.4286 µM 0.444066935358391 0.287491846050541 no 953 0.328497095505122 1510 7465181
SGTC_2717 st081029 62.2815 µM 0.443911088427024 0.287554290775407 no 954 0.328553433696556 1599 5292846
SGTC_2226 7298446 200 µM 0.443644950745292 0.287660941603842 no 955 0.328649650669348 1623 3283010
SGTC_545 4218-0007 221 µM 0.442614813520739 0.288073930322662 no 956 0.329022184064462 1565 2840508
SGTC_1795 st049545 62.3 µM 0.441014091611805 0.288716224808097 no 957 0.329601397695577 1663 5291882
SGTC_2215 7188065 200 µM 0.440190522935327 0.289046946741935 no 958 0.329899561552077 1612 940217
SGTC_3111 9122088 49.47 µM 0.439809826897089 0.289199883724443 no 959 0.330037424855838 1629 16876704
SGTC_2551 apiole 73.87 µM 0.439787113291425 0.289209009661486 no 960 0.330045650973991 1559 10659 A possible DNA adduct former.
SGTC_8 0354-0001 70 µM 0.438249358901046 0.289827167594246 no 961 0.33060276577498 1593 4993152
SGTC_179 1273-0063 6.77 µM 0.438137227852589 0.289872267101193 no 962 0.330643404565743 1512 3108139
SGTC_1590 st077108 57.8 µM 0.437837086079821 0.289993001385197 no 963 0.330752192456262 1632 5489485
SGTC_742 0kpi-0133 140 µM 0.437672849143661 0.290059076905835 no 964 0.330811727009932 1676 2728852
SGTC_564 3555-0129 330 µM 0.436487922741927 0.290536003443359 no 965 0.331241379934664 1562 563260
SGTC_2826 7992541 19.48 µM 0.435955739925118 0.29075032353271 no 966 0.331434421163134 1625 2985066
SGTC_1821 st053465 65.6 µM 0.435563629613439 0.290908281060733 no 967 0.331576681881323 1540 675086
SGTC_385 1494-0393 12.4 µM 0.434636614198054 0.291281878904384 no 968 0.331913106993302 1596 3090647
SGTC_2374 9071832 200 µM 0.431673315608087 0.292477621757234 no 969 0.33298943213686 1553 17381698
SGTC_3201 9113999 49.47 µM 0.43148109116426 0.292555266424277 no 970 0.333059299294558 1655 16649224
SGTC_936 3005-4620 401 µM 0.430996668037869 0.292750980537337 no 971 0.333235396602111 1680 777207
SGTC_50 0929-0078 56.389 µM 0.430934957921888 0.292775916702826 no 972 0.333257832080723 1629 1377751
SGTC_1789 tunicamycin 25 nM 0.429916497226657 0.293187604321749 no 973 0.333628192235018 1545 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_1058 3448-5425 97.3 µM 0.429382085962878 0.293403734212416 no 974 0.333822594180508 1547 7279705
SGTC_2346 9031566 143.75 µM 0.427922200103124 0.293994526157213 no 975 0.334353881835569 1680 4771086
SGTC_769 0302-0231 76 µM 0.426446808062981 0.294592151388331 no 976 0.334891149876859 1632 571869 YER009W NTF2
SGTC_586 0957-0265 8.15 µM 0.425110176082937 0.295134053591569 no 977 0.335378180023976 1589 6752309 YPR165W | YPR107C RHO1 | YTH1
SGTC_3273 9137859 49.47 µM 0.424779374800155 0.295268239076923 no 978 0.335498757231359 1634 2377234
SGTC_2588 indole-3-carbinol 100 µM 0.424008740790021 0.295580946167294 no 979 0.335779719350859 1715 3712 Induces cell cycle arrest.
SGTC_1945 st075991 56.6 µM 0.423984743810074 0.295590686081536 no 980 0.335788469780797 1546 1084980
SGTC_646 4092-0839 27.3 µM 0.423188280716693 0.29591403886903 no 981 0.336078948253921 1667 877796
SGTC_1283 0922-0125 16.4 µM 0.422819370629804 0.296063866184571 no 982 0.336213526837271 1689 3360884
SGTC_2661 dactinomycin 12.96 µM 0.422253646877212 0.296293694035514 no 983 0.336419943919859 1596 45006140 An Actinomycin D Classic transcription inhibitor.
SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM 0.421768371820126 0.296490904403436 no 984 0.33659704677582 1695 756377
SGTC_784 4579-0127 173 µM 0.421548300894326 0.296580358591998 no 985 0.336677374391904 1732 1948547
SGTC_3125 9127534 49.47 µM 0.419002254645694 0.297616170392126 no 986 0.337607242292807 1568 1639235
SGTC_2174 5790901 200 µM 0.417133826383511 0.298377354659288 no 987 0.338290262031015 1602 786020
SGTC_3354 9151612 71.43 µM 0.412527383369191 0.300257760919216 no 988 0.339976457009022 1695 27261949
SGTC_218 alverine citrate 93.75 µM 0.412284085845322 0.300357226717341 no 989 0.340065605845438 1662 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_3047 9092122 49.47 µM 0.411905715016285 0.300511943261835 no 990 0.340204265874386 1573 17173831
SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM 0.410956497468153 0.300900238417378 no 991 0.340552216875928 1684 1377
SGTC_1447 4239-0816 81.9 µM 0.410837030531509 0.300949124624292 no 992 0.340596019032074 1553 1341554
SGTC_983 1491-0821 12.2 µM 0.410667434113902 0.301018530105773 no 993 0.340658204688443 1718 46495113
SGTC_252 miconazole 1.30953 nM 0.410425587508828 0.301117515666145 no 994 0.340746889701054 1622 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_1655 st012546 55.1 µM 0.409856807326931 0.301350369881535 no 995 0.340955495760562 1605 720985 YLR208W SEC13
SGTC_1516 st013856 110 µM 0.409112899376302 0.301655042346424 no 996 0.341228405149093 1593 5281404 A mutagen and neurotoxin.
SGTC_934 2950-0684 338 µM 0.409021472382524 0.301692496438757 no 997 0.341261951706818 1722 1121253
SGTC_2621 lithochol-11-enic acid 100 µM 0.408654432677884 0.301842879409577 no 998 0.341396639203496 1759 6708711
SGTC_1624 st003710 6.25 µM 0.408048147883145 0.302091359281422 no 999 0.34161916341243 1713 24207033
SGTC_2908 7930301 100 µM 0.407303149897607 0.302396815092245 no 1000 0.341892674796476 1529 2223178
SGTC_1376 2910-0861 41.3 µM 0.406971462811433 0.302532854302051 no 1001 0.342014473910693 1637 1112859
SGTC_2923 7992654 58.14 µM 0.406908952149998 0.302558495698063 no 1002 0.34203743034882 1614 2985126
SGTC_1052 3253-3998 198 µM 0.406724728641923 0.302634068439257 no 1003 0.342105088053134 1584 5450317
SGTC_446 go6976 132 µM 0.406333846249222 0.30279444543785 no 1004 0.342248659838922 1706 3501 A protein kinase C inhibitor.
SGTC_2605 digitonin 300 nM 0.404755512395722 0.303442414302928 no 1005 0.342828616386709 1700 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_3329 9141233 27.5565 µM 0.404522376742935 0.303538178253483 no 1006 0.342914313197573 1696 4909101 YNL103W MET4
SGTC_3355 9151058 44.0485 µM 0.404365221992404 0.303602739528414 no 1007 0.342972085245833 1605 17015728
SGTC_2584 androsterone 48.74 µM 0.403675007352401 0.303886361504563 no 1008 0.343225860219864 1637 2754130 A steroid.
SGTC_2565 isoliquiritigenin 100 µM 0.402413013304636 0.304405243531119 no 1009 0.343690047225614 1530 638278 Binds to benzodiazepine receptor 65X better than valium.
SGTC_1142 3253-1408 9.78 µM 0.402158988394936 0.304509736188469 no 1010 0.343783511267466 1674 256655
SGTC_2576 guaiol 23.12 µM 0.400750770622715 0.305089293095068 no 1011 0.344301813524499 1789 227829
SGTC_1831 st055328 12 µM 0.400080939024951 0.305365136377962 no 1012 0.344548451446145 1719 1103068
SGTC_1691 st019933 84.6 µM 0.397701213470608 0.306346024177631 no 1013 0.345425221419367 1727 6176082
SGTC_1350 1495-0454 146 µM 0.395663173026669 0.307187179409572 no 1014 0.346176763346008 1707 1069057
SGTC_3230 9131665 49.47 µM 0.395208791836696 0.3073748536 no 1015 0.3463444023904 1644 15943720
SGTC_986 1493-0483 84 µM 0.394066255885092 0.307846980883192 no 1016 0.346766061682401 1716 40079
SGTC_208 k072-0098 12.366 µM 0.394052998419987 0.307852461102025 no 1017 0.346770955539522 1635 5948901
SGTC_538 2922-0838 53.3 µM 0.39327431840808 0.308174418067909 no 1018 0.347058442096607 1762 777039
SGTC_2081 5214970 32.255 µM 0.392045664113635 0.308682723896277 no 1019 0.347512236962687 1729 2063512
SGTC_649 1123-0311 367 µM 0.39113479041773 0.309059797731163 no 1020 0.347848802949972 1697 693629 YIL048W NEO1
SGTC_2756 carbadox 75.1 µM 0.390835722716648 0.309183646517217 no 1021 0.347959334024735 1636 2553 A substituted quinoxaline antibiotic. YLR208W SEC13
SGTC_3141 9094609 49.47 µM 0.389255197550317 0.309838527523371 no 1022 0.348543687521629 1581 25236309 YDL196W YDL196W
SGTC_1099 5-nonyloxytryptamine 2.85 µM 0.388843910303082 0.310009041007064 no 1023 0.348695808110154 1589 23581825 A 5-HT1D beta serotonin receptor agonist.
SGTC_283 0987-0079 11.7 µM 0.388746344359668 0.310049496373243 no 1024 0.348731897868871 1733 411556
SGTC_2084 5306078 60.6385 µM 0.388229757237946 0.310263735670526 no 1025 0.348923006865064 1688 679340
SGTC_3243 9134147 49.47 µM 0.387886654742594 0.310406062926336 no 1026 0.349049957219466 1691 24282180
SGTC_1996 st072960 66.8 µM 0.38604857650493 0.311169025549541 no 1027 0.349730346596843 1757 1719405
SGTC_40 0327-0103 19.753 µM 0.386026152604617 0.311178338442381 no 1028 0.349738650091022 1592 409036
SGTC_1223 0764-0573 147 µM 0.385917315617666 0.311223541359188 no 1029 0.34977895307889 1627 1609797
SGTC_958 1222-0007 33 µM 0.385903292244845 0.311229365848721 no 1030 0.349784146140923 1737 7312461
SGTC_898 1000-0849 28.3 µM 0.383917586317556 0.31205458866902 no 1031 0.350519765687366 1696 6751807
SGTC_1084 voriconazole 435 nM 0.383349954285232 0.312290659785917 no 1032 0.350730152415331 1754 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_2511 berberine 10.47 µM 0.383290840086562 0.312315249080551 no 1033 0.350752065092752 1640 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_1570 verbenone 133 µM 0.382017336419627 0.312845181780931 no 1034 0.351224252760307 1788 29025 A natural terpanoid with antifungal properties.
SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM 0.380583113653628 0.313442456561162 no 1035 0.351756306669737 1711 5393153
SGTC_104 0074-0074 590.992 µM 0.378650072646008 0.314248236069826 no 1036 0.352473866727349 1720 3943124
SGTC_2077 5212015 200 µM 0.376917384513429 0.314971252669608 no 1037 0.353117500830718 1582 780900
SGTC_1481 3346-2004 36 µM 0.37646345556041 0.315160785690111 no 1038 0.35328618941488 1664 2770522
SGTC_2375 9072683 200 µM 0.376090277242947 0.315316638629485 no 1039 0.353424891129599 1814 16798029
SGTC_1643 st009866 20.2 µM 0.376061857611499 0.315328509056198 no 1040 0.353435454844613 1746 3156273 YOR207C RET1
SGTC_1699 st031318 29.054 µM 0.374353759024133 0.316042304261939 no 1041 0.354070570429807 1721 5340658
SGTC_1546 5-methoxyflavanone 78.7 µM 0.37310377059425 0.316565095462151 no 1042 0.354535606228993 1771 147795
SGTC_2055 5235184 200 µM 0.372218838711703 0.316935428332578 no 1043 0.354864960468674 1683 2836034
SGTC_1760 st045453 10.4495 µM 0.371631188613391 0.317181453914929 no 1044 0.355083732240007 1766 3323419 YIL048W NEO1
SGTC_639 0833-0042 114 µM 0.37161936519379 0.317186404737381 no 1045 0.355088134381256 1631 5978911 YPR085C | YHR062C ASA1 | RPP1
SGTC_2362 9071156 126 µM 0.369559376190016 0.318049483064156 no 1046 0.355855412235794 1729 653133
SGTC_3293 9120939 62.045 µM 0.369325652833395 0.318147469236721 no 1047 0.35594250342821 1718 934087
SGTC_318 1488-0629 67.2 µM 0.367801311205681 0.318786846141814 no 1048 0.356510695626799 1647 3662576
SGTC_2581 avocatin a 64 µM 0.367585065457312 0.318877593019859 no 1049 0.356591326192899 1663 6710728 A skin care supplement.
SGTC_1554 st069299 38.7 µM 0.366381557709717 0.319382839706073 no 1050 0.357040189648562 1738 24207999
SGTC_1387 3342-1166 1.8 µM 0.366256952106832 0.319435169786081 no 1051 0.357086674205115 1697 3418228
SGTC_2533 agelasine 13.65 µM 0.366079952207615 0.319509509856282 no 1052 0.357152708284373 1843 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase.
SGTC_1347 1493-0251 600 nM 0.365598880281988 0.319711597016021 no 1053 0.357332205377167 1788 3986378
SGTC_2742 clothiapine 36.27 µM 0.364751227881654 0.320067806376439 no 1054 0.357648557427655 1778 16351 An atypical antipsychotic. YIL048W NEO1
SGTC_581 0958-0271 211 µM 0.363870352514546 0.320438152860093 no 1055 0.357977412258984 1624 4591145
SGTC_1104 tacrolimus 29.8 µM 0.363630396636923 0.320539068540469 no 1056 0.358067012621007 1702 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41
SGTC_1694 st024011 44.9 µM 0.363370405579358 0.320648425178839 no 1057 0.358164103013894 1705 2787533
SGTC_2550 chrysin dimethyl ether 71.87 µM 0.362028376942647 0.321213152548751 no 1058 0.358665412493205 1681 88881 An O-methylated flavonoid and antioxidant.
SGTC_2788 5282734 71.43 µM 0.361584396800469 0.32140007109073 no 1059 0.358831313184723 1806 743706
SGTC_1842 st055362 61.2 µM 0.361228805080775 0.32154981015812 no 1060 0.358964205257317 1745 676032
SGTC_505 gw-5074 63.9 µM 0.36096727837345 0.321659957117664 no 1061 0.359061954160288 1761 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases.
SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM 0.360233346298513 0.321969150315798 no 1062 0.359336319791691 1721 6708739 YPR165W RHO1
SGTC_1589 2',5'-dimethoxyflavone 47.2 µM 0.359973040357252 0.322078842444802 no 1063 0.359433647327266 1667 688667
SGTC_3215 9129942 49.47 µM 0.358636487979066 0.322642305493996 no 1064 0.359933523378705 1817 17682944
SGTC_2217 6934799 96.0675 µM 0.35704571483966 0.323313473943431 no 1065 0.360528791350046 1755 675606
SGTC_3290 9121031 71.43 µM 0.356419253109719 0.323577944573361 no 1066 0.360763306480252 1648 17014854
SGTC_1600 coumarin 106 71.1 µM 0.355296132354078 0.324052310677385 no 1067 0.361183876318996 1733 100336 A hepatotoxic, DNA x-linker.
SGTC_3321 9137793 26.8275 µM 0.352860173089015 0.325082154389082 no 1068 0.362096634960519 1691 4904192
SGTC_480 am 92016 50 µM 0.351977279816299 0.325455743438652 no 1069 0.362427650818428 1656 2129 K+ channel blocker.
SGTC_1158 4092-0494 91.8 µM 0.351370049316423 0.325712789898296 no 1070 0.362655374444046 1783 1148199
SGTC_744 1594-0068 283 µM 0.350515844659138 0.326074523165797 no 1071 0.362975800576786 1693 668392
SGTC_1064 honokiol 6.76 µM 0.350366055855004 0.326137971677384 no 1072 0.363031998700232 1716 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis.
SGTC_1780 st038448 24.544 µM 0.350023556256906 0.326283068784625 no 1073 0.363160509602807 1793 728868 YDL195W SEC31
SGTC_3265 9137266 49.47 µM 0.349966694455113 0.326307160360022 no 1074 0.363181846481438 1858 17224265
SGTC_103 0844-0104 51.839 µM 0.349341451908877 0.326572114938018 no 1075 0.363416491101737 1787 5375804
SGTC_332 4112-0506 40.9 µM 0.348482656838815 0.326936183030866 no 1076 0.363738868194039 1725 2790355
SGTC_2363 9053361 176 µM 0.34375981236636 0.328941270814588 no 1077 0.365513462709398 1820 6469797 YMR079W SEC14
SGTC_1618 st003135 44.5 µM 0.340816076695077 0.330193535972235 no 1078 0.36662102342186 1814 1270615
SGTC_1672 st016598 6.51 µM 0.339301135229 0.330838735305039 no 1079 0.367191443766295 1671 4665860 YNL267W PIK1
SGTC_284 0988-0104 32.6 µM 0.339157059924466 0.3309001218366 no 1080 0.36724570767747 1789 4666532
SGTC_1545 lovastatin 49.4 µM 0.338949861428794 0.330988411398109 no 1081 0.367323750687917 1738 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12
SGTC_2823 7987624 58.44 µM 0.33826859817832 0.331278771414727 no 1082 0.367580392693764 1723 2239440
SGTC_54 0159-0055 9 µM 0.338189398116079 0.33131253372126 no 1083 0.367610232375919 1827 3319099
SGTC_2640 pentamidine 10.38 µM 0.337322261729732 0.331682276154362 no 1084 0.367936989845176 1862 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_387 norethindrone acetate 66.7 µM 0.336760777310228 0.33192177770742 no 1085 0.368148621436882 1688 541197
SGTC_2684 capsaicin 100 µM 0.335999379515554 0.332246662170924 no 1086 0.368435667187918 1756 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_2435 5706476 10.6 µM 0.335146494440828 0.332610733526559 no 1087 0.368757290701696 1884 5725375
SGTC_2162 5663267 200 µM 0.33498989983745 0.33267759629181 no 1088 0.368816352624897 1819 6456493
SGTC_201 4262-0159 12.803 µM 0.334899047940687 0.332716390675552 no 1089 0.368850620154219 1841 1341029
SGTC_2762 leflunomide 42.06 µM 0.334898627919808 0.332716570031511 no 1090 0.368850778580165 1734 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1
SGTC_3168 9103419 49.47 µM 0.334534874655032 0.33287191314623 no 1091 0.368987989541318 1799 16649256
SGTC_1605 st000082 49.1 µM 0.333956598219837 0.333118928780873 no 1092 0.369206154913714 1794 1114022
SGTC_2227 7312221 64.1025 µM 0.333376941998129 0.333366606482421 no 1093 0.369424883122705 1781 887188 YOR168W | YOR169C GLN4 | YOR169C
SGTC_1713 st033146 12.748 µM 0.333085201323185 0.333491290039074 no 1094 0.369534984912342 1845 674619
SGTC_1190 1486-1332 13 µM 0.332578421173418 0.333707920471594 no 1095 0.369726267189876 1679 4150046
SGTC_2549 cedrol 20.94 µM 0.332145291143127 0.333893112055517 no 1096 0.369889776060256 1816 6708665 A sedative which affects the nervous system.
SGTC_2257 7960413 200 µM 0.329988821874325 0.334815746029445 no 1097 0.370704204170578 1803 2974689 YIL048W NEO1
SGTC_1420 4'-methoxyflavone 42 µM 0.329555283046706 0.335001353993695 no 1098 0.370868007748838 1857 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13
SGTC_892 0929-0076 29 µM 0.329387936259284 0.335073009794331 no 1099 0.370931242494656 1719 5751038
SGTC_2394 5221648 200 µM 0.328935553804344 0.33526674434385 no 1100 0.371102200115301 1845 788586
SGTC_2075 5212009 200 µM 0.328642251129974 0.335392375777873 no 1101 0.371213054277852 1819 780898
SGTC_2152 5568786 200 µM 0.327916347457109 0.335703383957164 no 1102 0.37148745653513 1753 5399883
SGTC_2747 doxorubicin 7.63 µM 0.327587690217273 0.335844231810169 no 1103 0.371611715293617 1838 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_587 k089-0003 57 µM 0.324122205248482 0.337330784489677 no 1104 0.372922758132878 1846 9659696
SGTC_1875 nocodazole 6 µM 0.323832860494488 0.337455017004136 no 1105 0.373032288259492 1862 4122 A microtubule depolymerizer. YJL014W CCT3
SGTC_723 4182-0001 115 µM 0.322570943998532 0.337997038089243 no 1106 0.373510100830845 1721 744821 YLR208W SEC13
SGTC_1552 6-methylflavone 10.6 µM 0.322416845766409 0.338063249738042 no 1107 0.37356846198966 1858 689013
SGTC_1787 fluconazole 80 µM 0.321779585464535 0.338337115628455 no 1108 0.373809840438909 1742 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C
SGTC_1029 k015-0030 64.7 µM 0.32060412218881 0.338842501349618 no 1109 0.374255206671271 1788 2208316
SGTC_1971 st069429 63.5 µM 0.320448455995422 0.338909451187706 no 1110 0.374314198966354 1872 1246522 YGL099W LSG1
SGTC_3021 9087658 49.47 µM 0.319195718689515 0.33944842096491 no 1111 0.374789051644722 1840 25237042
SGTC_680 0417-1641 114 µM 0.318841273213425 0.339600975026093 no 1112 0.374923439436738 1723 2835990
SGTC_1658 st012944 20 µM 0.318841138694684 0.339601032928227 no 1113 0.374923490442323 1822 24207260
SGTC_2534 helenine 20.12 µM 0.31874075437183 0.339644243326843 no 1114 0.374961553860986 1731 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58
SGTC_2989 9073649 71.4286 µM 0.318470996175443 0.3397603710942 no 1115 0.375063845976828 1900 21367202
SGTC_221 trifluoperazine 10.304 µM 0.31748672412429 0.340184217698424 no 1116 0.375437155720244 1754 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1
SGTC_1620 st003704 16.5 µM 0.315754112915968 0.340930804177287 no 1117 0.376094575026278 1882 2834414
SGTC_226 1,3-diallylurea 8.28947 mM 0.315538724191579 0.341023659336623 no 1118 0.37617632696709 1779 74537 YKL182W FAS1
SGTC_1652 st011932 78 µM 0.314106273268208 0.341641440864587 no 1119 0.376720162556319 1833 1551076
SGTC_2069 5228469 200 µM 0.313201750486013 0.342031758455098 no 1120 0.377063694296136 1726 2835210
SGTC_1430 4049-0248 69.1 µM 0.313005396554372 0.342116510974457 no 1121 0.377138281081075 1869 22774488
SGTC_2356 9061756 188.97 µM 0.312513056408715 0.342329055403377 no 1122 0.377325321010685 1889 20104043
SGTC_1606 st000094 49.2 µM 0.311907917849791 0.34259036360301 no 1123 0.377555252459004 1915 1242210
SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM 0.311029270043699 0.342969911436573 no 1124 0.377889185079296 1864 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_694 1315-0438 43.2 µM 0.309926410915322 0.343446535731929 no 1125 0.378308459006529 1808 6793154
SGTC_1919 st067113 52.3 µM 0.309814670198348 0.343494840794206 no 1126 0.378350947476776 1732 1268243
SGTC_2936 9038235 15.59 µM 0.309277598195706 0.343727050516894 no 1127 0.378555185117215 1743 4749415
SGTC_373 0844-0104 25.9 µM 0.308125105072852 0.344225544134595 no 1128 0.378993569434411 1879 5375804
SGTC_702 1488-0190 94 µM 0.307624458936476 0.344442175528315 no 1129 0.37918405331098 1904 949357
SGTC_873 0591-4978 488 µM 0.306965082333583 0.344727568036292 no 1130 0.379434975091696 1937 3305145
SGTC_1703 st026983 48.3 µM 0.30691143950582 0.344750789706536 no 1131 0.379455390781089 1871 1104023
SGTC_2294 7971431 200 µM 0.306705045761479 0.344840141820236 no 1132 0.379533944408323 1814 5741572
SGTC_2211 7117706 200 µM 0.306658459492824 0.344860311175253 no 1133 0.379551675868122 1846 822771
SGTC_3183 9108214 49.47 µM 0.305706703727829 0.345272466800493 no 1134 0.379913984346241 1850 4974831
SGTC_3054 9094397 49.47 µM 0.305051719264977 0.345556212970149 no 1135 0.380163381029356 1716 2598354
SGTC_2745 rifampicin 24.3 µM 0.304856783971425 0.345640677760852 no 1136 0.380237615647496 1906 25141428 Inhibits bacterial DNA-dependent RNA polymerase.
SGTC_1393 3470-5649 58.2 µM 0.303977617494032 0.346021712998566 no 1137 0.380572471716706 1762 4108395
SGTC_3325 9138760 55.175 µM 0.301693278466449 0.347012485470426 no 1138 0.381442946343289 1731 43844959
SGTC_1123 mangostin 811.285 nM 0.300344002459109 0.347598190974258 no 1139 0.381957386236892 1744 5281650 An antioxidant.
SGTC_329 k048-0121 21.3 µM 0.30028998085617 0.347621648730516 no 1140 0.38197798745777 1760 6832902
SGTC_2002 4023503 131 µM 0.299617412306999 0.347913746443856 no 1141 0.382234500466015 1968 4736863 YCR052W RSC6
SGTC_1754 st042065 16.137 µM 0.298157535882431 0.348548083821317 no 1142 0.38279146501706 1818 1126236 YIL048W NEO1
SGTC_824 1304-0008 100 µM 0.297490316166914 0.348838141616323 no 1143 0.383046100057156 1789 768245
SGTC_616 4092-0450 108 µM 0.297155805096742 0.34898359556197 no 1144 0.383173780542514 1817 787165
SGTC_569 4130-2812 160 µM 0.29666348908509 0.349197707482388 no 1145 0.38336171712876 1910 743552
SGTC_3177 9107506 49.47 µM 0.295470782499973 0.349716623433882 no 1146 0.383817134356592 1876 8897194
SGTC_2840 9008771 71.43 µM 0.295290672790682 0.349795008969351 no 1147 0.383885920528823 1943 2992978
SGTC_2372 9071633 200 µM 0.295001516960619 0.349920865850332 no 1148 0.383996360442134 1906 21321366
SGTC_2056 5235370 200 µM 0.293950162648069 0.350378613273536 no 1149 0.384397993085413 1761 5511916
SGTC_1416 3966-0321 25.3 µM 0.293482017408366 0.350582508252444 no 1150 0.384576871347912 1806 582530 YLR208W SEC13
SGTC_2867 9039098 71.43 µM 0.291941395307924 0.351253811217038 no 1151 0.385165716282486 1764 6463460
SGTC_152 4469-0003 551.229 µM 0.291825248037049 0.351304439496583 no 1152 0.385210119968838 1931 697280
SGTC_1788 fluconazole 20 µM 0.290406328376734 0.351923155498149 no 1153 0.385752701437825 1756 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11
SGTC_217 ketoconazole 989 nM 0.290149368418333 0.352035244180756 no 1154 0.385850984442375 1820 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4
SGTC_2364 9055074 200 µM 0.289250934904956 0.352427251506314 no 1155 0.386194678210918 1737 6470630
SGTC_3343 9148379 18.9835 µM 0.289023113837566 0.352526680047016 no 1156 0.38628184486793 1913 1955036
SGTC_1273 0849-0096 14.1 µM 0.288703414925987 0.352666224065513 no 1157 0.386404174600105 1767 5286025
SGTC_623 k072-0108 16.9 µM 0.288575928549407 0.352721875582621 no 1158 0.38645295919305 1821 5382803
SGTC_1917 st066507 28.5 µM 0.288300614546689 0.352842068916281 no 1159 0.386558318388372 1755 3156428
SGTC_1125 tnp00248 1.32998 µM 0.288166337516062 0.352900695325027 no 1160 0.386609707548426 1967 24207736
SGTC_134 0269-0018 6.916 µM 0.287961980770736 0.352989925791259 no 1161 0.386687920730609 1753 4378915
SGTC_344 k064-0035 6.43 µM 0.287583856457681 0.3531550515626 no 1162 0.386832651875342 1729 5088750
SGTC_2050 5263056 171 µM 0.287501563346094 0.35319099238661 no 1163 0.386864152534362 1928 763468 YGL055W OLE1
SGTC_2205 7238770 200 µM 0.287319718136679 0.353270416395241 no 1164 0.386933762995156 1905 279867
SGTC_1311 1190-0148 100 µM 0.286061755843326 0.353820027829779 no 1165 0.387415411247281 1899 1961333
SGTC_2898 9056270 58.44 µM 0.285057660631851 0.354258941986212 no 1166 0.387799983383818 1817 19154699
SGTC_881 0833-0569 170 µM 0.284429719818939 0.354533528480976 no 1167 0.388040542985337 1727 5418700
SGTC_2463 5473429 200 µM 0.283727603071945 0.354840640231389 no 1168 0.388309569731138 1796 5399405
SGTC_2488 5268135 45.7 µM 0.283486396822813 0.354946167652129 no 1169 0.388402003961857 1883 1270356 YLR208W SEC13
SGTC_2763 lisinopril 49.32 µM 0.283469732723353 0.354953458585079 no 1170 0.388408390154324 1922 5362119 A lysine-analog of enalapril and an ACE inhibitor.
SGTC_592 k241-0073 46.5 µM 0.281999674838781 0.355596852013286 no 1171 0.3889718798144 1919 4230158
SGTC_3073 9114972 49.47 µM 0.280818924174109 0.356113923912752 no 1172 0.389424644027042 1943 41905075
SGTC_2379 9035213 200 µM 0.279976379416996 0.356483051285771 no 1173 0.38974781347843 1960 646551
SGTC_1094 duloxetine 25.4 µM 0.279398323772255 0.356736381112905 no 1174 0.389969578660103 1826 60834 A selective serotonin reuptake inhibitor.
SGTC_302 1094-0063 18.9 µM 0.278663913333258 0.357058323748198 no 1175 0.390251379425916 1814 5440289
SGTC_304 1310-0298 97 µM 0.278040207193357 0.357331817027644 no 1176 0.390490747121495 1832 1550234
SGTC_348 k064-0012 10.7 µM 0.277457627816577 0.357587342560178 no 1177 0.390714368571842 1774 5066323
SGTC_2545 solidagenone 89.61 µM 0.277030525932286 0.357774714575883 no 1178 0.390878333394751 1833 6708572 An anti ulcer agent
SGTC_2178 5812956 200 µM 0.276622391314917 0.357953797572701 no 1179 0.391035034794315 1832 5403383
SGTC_2310 7668677 200 µM 0.273997309032373 0.359106387745714 no 1180 0.392043344818375 1851 2197143
SGTC_460 trequinsin 123 µM 0.271775627548106 0.360082860928813 no 1181 0.392897273242411 1892 5537 A vasodilator.
SGTC_225 nsc-122657 1.016 µM 0.271574041378949 0.360171507364405 no 1182 0.39297478074861 1883 275685
SGTC_1557 sumaresinolic acid 42.3 µM 0.271482312481783 0.36021184714387 no 1183 0.393010050833386 1786 9982268 A natural terpine and antifungal of unknown mechanisn.
SGTC_1424 4048-1941 275 µM 0.269533816710815 0.361069107610339 no 1184 0.393759461386275 1953 X1424
SGTC_1359 1582-0056 520 nM 0.268224244966091 0.361645659638349 no 1185 0.394263356875649 1880 3661189
SGTC_696 1560-0013 611 µM 0.267740749060626 0.361858603032938 no 1186 0.39444944065422 1889 1650269
SGTC_1583 clindamycin 39.6 µM 0.267551602658497 0.361941919368133 no 1187 0.394522244265344 1749 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis.
SGTC_2628 lathosterol 100 µM 0.26573961135241 0.3627404071724 no 1188 0.39521987720392 1836 6710616
SGTC_2079 5212404 121 µM 0.263171399258667 0.363873160307611 no 1189 0.396209237042692 1966 758462
SGTC_2796 7949634 45.45 µM 0.26283723531909 0.364020636683328 no 1190 0.396338017302121 1797 2971588
SGTC_528 3492-0019 172 µM 0.261863232439941 0.364450607643919 no 1191 0.396713443484507 1859 2869262
SGTC_2465 5809242 33.21 µM 0.261525533975473 0.364599723584978 no 1192 0.396843630613291 1899 2731748
SGTC_626 0214-0009 33 µM 0.260991276220087 0.36483567514013 no 1193 0.397049617372098 1923 3437874
SGTC_2139 5578692 56.4705 µM 0.260872267156896 0.364888241715408 no 1194 0.397095506050237 1968 650991 YMR113W FOL3
SGTC_1998 st075797 76.8 µM 0.260537295732161 0.365036212991248 no 1195 0.397224675253719 1956 24208315
SGTC_1139 k015-0024 46.9 µM 0.260106390018847 0.365226592122997 no 1196 0.397390854504908 1978 2766652
SGTC_599 1935-0052 86.5 µM 0.259981322439617 0.36528185464918 no 1197 0.397439090440147 1847 9557311
SGTC_2460 5552655 174.22 µM 0.259912233160125 0.365312383729282 no 1198 0.397465737394926 1808 5401989
SGTC_439 amiodarone 34.4 µM 0.259608828853514 0.365446461727426 no 1199 0.397582762672347 1904 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1
SGTC_3013 9080133 71.4286 µM 0.258652236252514 0.365869299046528 no 1200 0.397951787790023 1883 17050193
SGTC_3107 9121808 49.47 µM 0.257836781515659 0.366229878695348 no 1201 0.398266438210002 1969 662681
SGTC_720 r052-1644 49.9 µM 0.257818754424925 0.36623785129171 no 1202 0.398273394870565 1846 1422863 YOR257W CDC31
SGTC_1385 3091-4834 14.1 µM 0.252750616036739 0.368481546258153 no 1203 0.400230465736738 1922 4072814
SGTC_1097 itavastatin 7.23 µM 0.252647258555217 0.36852735022099 no 1204 0.400270403677308 1865 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49
SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM 0.252454759846254 0.368612663042414 no 1205 0.40034478909369 1968 6728940
SGTC_3300 9124615 50.48 µM 0.252066779060953 0.368784630550015 no 1206 0.400494723743164 1920 24824903
SGTC_2376 9072922 81.32 µM 0.251852971567391 0.368879409211854 no 1207 0.400577355628165 1908 17087968
SGTC_2314 7727897 200 µM 0.250783900679183 0.369353436854732 no 1208 0.400990594647753 1796 900724
SGTC_3015 9080845 49.47 µM 0.248528181714179 0.370354277206866 no 1209 0.401862884031677 1966 5296973
SGTC_2485 5633444 17.78 µM 0.247949646884224 0.370611109214817 no 1210 0.402086683165734 1785 5724239
SGTC_1693 xanthone 101.9 µM 0.247335695331416 0.370883727031915 no 1211 0.402324217939019 1926 7020 An insecticide.
SGTC_2214 7179297 48.276 µM 0.246412198380114 0.371293916820312 no 1212 0.40268158218518 1920 769744
SGTC_220 paclitaxel 373.376 µM 0.24589083107921 0.371525557232662 no 1213 0.402883370854355 1940 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_624 k048-0052 28 µM 0.244935789656916 0.371949997132781 no 1214 0.403253074711216 1889 6835531
SGTC_1753 st043925 64 µM 0.244433430155352 0.37217331845505 no 1215 0.403447576659464 1990 670181
SGTC_3083 9117465 49.47 µM 0.243614778210222 0.37253733805402 no 1216 0.403764590862349 1799 16420915
SGTC_3131 9127911 49.47 µM 0.243156947723586 0.372740965419669 no 1217 0.403941908399151 1903 45595681
SGTC_2649 anisomycin 9.56 µM 0.243032435240307 0.372796350474458 no 1218 0.403990135442539 1894 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_842 0271-0008 11.1 µM 0.242625304518631 0.372977466791087 no 1219 0.404147838336937 1937 1221709
SGTC_1089 terbinafine 2.25 µM 0.241958244867205 0.373274275857614 no 1220 0.404406258880485 1987 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_484 loperamide 105 µM 0.240909167917427 0.373741216118287 no 1221 0.404812758205046 1905 3955 An opioid-receptor agonist.
SGTC_2665 lovastatin 100 µM 0.239886637604955 0.374196518991232 no 1222 0.405209070047718 1887 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1
SGTC_28 pentachloropyridine N-oxide 1.606 µM 0.239373340719225 0.374425141311421 no 1223 0.405408050102602 1976 140250 A respiratory chain inhibitor.
SGTC_3089 9117425 49.47 µM 0.238975240670132 0.374602485395936 no 1224 0.405562390825255 1815 9401657
SGTC_3232 9132874 49.47 µM 0.23835862546045 0.374877225130521 no 1225 0.405801477389906 1834 3784940
SGTC_2496 diffractaic acid 79.83 µM 0.237921241958749 0.375072144704914 no 1226 0.405971089908615 2004 94870 An apoptosis inducer which activates caspases.
SGTC_2860 9025725 38.96 µM 0.237576431030309 0.375225831889796 no 1227 0.406104816244317 1796 40546248
SGTC_1812 st052057 4.327 µM 0.237309493205883 0.375344823518474 no 1228 0.406208348959122 1854 3645418
SGTC_2092 5303694 80.6725 µM 0.237139072659022 0.375420797295031 no 1229 0.406274450560472 1847 1963699
SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM 0.236264571349235 0.375810727456422 no 1230 0.406613688365992 1880 688788
SGTC_459 nigericin 15.3 µM 0.235918829581897 0.375964924781314 no 1231 0.406747828358633 1912 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification.
SGTC_161 4065-0411 162.148 µM 0.233564884506624 0.377015285743118 no 1232 0.407661395921889 1895 1906281 YLR208W SEC13
SGTC_45 0kpi-0036 14.9 µM 0.232194377172477 0.377627243987736 no 1233 0.408193522398308 1910 2795021
SGTC_1825 st052143 62.6 µM 0.231921967757376 0.377748916763195 no 1234 0.40829931092851 1981 674173
SGTC_2179 6298986 200 µM 0.230366167225604 0.37844405355922 no 1235 0.408903624417582 2028 738374
SGTC_525 k781-2675 26.7 µM 0.229859517057124 0.378670511580289 no 1236 0.409100467378676 2011 3651118 YDL195W SEC31
SGTC_2208 7283366 200 µM 0.229752014522997 0.378718567475265 no 1237 0.409142237051343 1997 898663
SGTC_1728 st035614 33.7865 µM 0.229637909806415 0.378769576736248 no 1238 0.40918657310382 1888 15945546
SGTC_2946 9065502 71.43 µM 0.229633149850656 0.378771704668109 no 1239 0.409188422637611 1981 16489101
SGTC_2001 4023502 57.655 µM 0.228876220449246 0.379110135662154 no 1240 0.409482561676494 1918 108941 YCR052W RSC6
SGTC_1723 st034307 2.5525 µM 0.228751723404715 0.379165808465931 no 1241 0.409530945499683 1867 867466
SGTC_2767 sibutramine 71.45 µM 0.226766630551127 0.380053843583454 no 1242 0.410302606364652 2019 64765 A serotonin-norepinephrine reuptake inhibitor.
SGTC_1322 1348-1070 12 µM 0.226743060745001 0.380064391391904 no 1243 0.410311770697436 1987 6758089
SGTC_1757 st041620 31.8375 µM 0.226449111345387 0.380195945233165 no 1244 0.410426067227552 1870 5289815
SGTC_3066 9117245 49.47 µM 0.226341576081378 0.380244074928944 no 1245 0.410467882133248 1954 17176980
SGTC_314 1671-0008 2.74 µM 0.22593860732385 0.380424448659808 no 1246 0.410624584902894 1933 3913060
SGTC_2964 9083345 53.42 µM 0.225415708016287 0.380658543524233 no 1247 0.410827946423171 1857 17741579
SGTC_194 1486-1323 56.904 µM 0.225253361734046 0.38073123262753 no 1248 0.41089108962792 1863 5178754
SGTC_1862 st057513 3.81 µM 0.224789509781847 0.380938941403418 no 1249 0.411071513615527 1901 5393163
SGTC_854 0422-0053 192 µM 0.223251544398383 0.381627873807458 no 1250 0.41166986873156 1985 3596728
SGTC_2947 9072639 7.68 µM 0.222870665134765 0.381798546916733 no 1251 0.411818084004576 1864 16488146
SGTC_468 gf-109203x 121 µM 0.222666492328502 0.381890046809732 no 1252 0.411897540946991 2032 2396 A protein kinase C inhibitor.
SGTC_2705 st078069 42.8 µM 0.221228755201007 0.382534554204651 no 1253 0.412457160245463 1902 1530061
SGTC_418 lividomycin a 100 µM 0.221152820887947 0.38256860302933 no 1254 0.412486721586123 2010 72394 An antibiotic.
SGTC_550 4123-0385 25.7 µM 0.221017913486046 0.382629097531754 no 1255 0.412539242462065 1898 5731123
SGTC_891 0929-0073 133 µM 0.220110606939256 0.383036021727407 no 1256 0.412892507118001 1998 5603632
SGTC_2495 cafestol 54.53 µM 0.219285928811308 0.383405999357836 no 1257 0.413213661175415 1955 16667697 An anti-infammatory.
SGTC_3044 9093193 49.47 µM 0.217774788304553 0.384084222271222 no 1258 0.413802294566924 1847 25236277
SGTC_44 0929-0055 61.211 µM 0.217771618808949 0.38408564516312 no 1259 0.413803529382148 1890 1379590
SGTC_2513 baicalein 25.65 µM 0.217117005050065 0.384379556489727 no 1260 0.41405858096643 1843 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2
SGTC_105 0111-0055 734.78 µM 0.216309132274582 0.384742370355503 no 1261 0.414373395522271 1943 5179370
SGTC_1103 duloxetine 36.1 µM 0.216085787189956 0.384842691963409 no 1262 0.414460439095421 2003 60835 A selective serotonin reuptake inhibitor.
SGTC_1072 oxiconazole 14.9 nM 0.215570041276725 0.385074382921404 no 1263 0.41466145516237 1947 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_1761 st044296 37 µM 0.215462216994855 0.385122826518867 no 1264 0.414703483359268 1921 1826700
SGTC_944 3370-0224 231 µM 0.215393917368648 0.385153513295152 no 1265 0.414730105976711 1870 4580514
SGTC_1702 st027038 51 µM 0.215260369073901 0.385213518141293 no 1266 0.414782163105579 1955 5521182
SGTC_1480 1070-0044 41.2 µM 0.213951369768349 0.385801812470001 no 1267 0.415292490155469 2017 3124987
SGTC_3227 9130768 49.47 µM 0.212790155668173 0.386323908725192 no 1268 0.415745321272922 1971 17720899
SGTC_291 SEC14.278 35.5 µM 0.212715928379318 0.386357289245351 no 1269 0.415774271017902 2015 1068044
SGTC_3285 9112818 20.8695 µM 0.212668885952269 0.386378444982423 no 1270 0.415792618499719 1966 17017947 YPR165W RHO1
SGTC_1724 st037281 8.293 µM 0.212257909941106 0.38656328187194 no 1271 0.415952915117187 1878 574124 YDL195W SEC31
SGTC_2066 5222451 176 µM 0.211889437934146 0.386729024426552 no 1272 0.416096645410994 1977 2281147
SGTC_1023 4482-3888 16 µM 0.209336191275511 0.387878067510327 no 1273 0.417092900517844 2033 3303168
SGTC_2149 5554786 194.827 µM 0.208610080253039 0.388205020683068 no 1274 0.417376320401728 1919 745063 YPR165W RHO1
SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM 0.207212642449765 0.388834481625141 no 1275 0.417921897167114 1995 4000243
SGTC_1515 3460-0031 42.1 µM 0.206994860285737 0.388932605612563 no 1276 0.418006936237172 1992 2876596
SGTC_2131 toluylene red 5.2905 µM 0.206033827116649 0.38936569350127 no 1277 0.418382243953528 1885 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain.
SGTC_2108 5365811 200 µM 0.204796723172318 0.389923394489741 no 1278 0.418865473642102 1984 780283
SGTC_1635 st007035 42.4 µM 0.204570343566235 0.39002547364456 no 1279 0.418953913880667 1990 3716403
SGTC_1205 4161-2785 76 µM 0.203982320552358 0.390290660565567 no 1280 0.419183657302608 1832 3498106
SGTC_2732 terfenadine 20 µM 0.203676622031354 0.390428544819989 no 1281 0.419303106078662 2021 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.
SGTC_992 3909-8734 162 µM 0.202109693898681 0.391135518326598 no 1282 0.419915484808203 1902 4288319
SGTC_1475 4092-1048 11.7 µM 0.202038961279342 0.391167440286347 no 1283 0.419943132750151 1963 2881759
SGTC_3108 9121785 49.47 µM 0.200652645668687 0.391793238708929 no 1284 0.420485094914115 2071 17140271
SGTC_2378 9074213 121.43 µM 0.199217641941884 0.392441310501001 no 1285 0.421046249868734 2032 657714
SGTC_2104 5389443 200 µM 0.196449624168444 0.393692235307573 no 1286 0.422129129205014 2026 2244536
SGTC_1603 st002045 67.8 µM 0.196275657651243 0.39377089119771 no 1287 0.422197206596835 2074 5887985
SGTC_175 3793-3120 23.7 µM 0.196208642985138 0.393801191852699 no 1288 0.422223431709972 1933 5322297
SGTC_2059 5238311 157 µM 0.195422093268966 0.394156878013127 no 1289 0.422531261052043 1922 703021
SGTC_1398 3558-0053 112 µM 0.195285108015854 0.394218833239467 no 1290 0.422584877357597 1953 4532369
SGTC_41 0478-0632 82.643 µM 0.194741364769188 0.394464781977293 no 1291 0.422797713702407 2117 3750424
SGTC_2277 7947813 106.88 µM 0.19377340350013 0.394902719258702 no 1292 0.42317665660417 2036 1246798
SGTC_482 fipronil 114 µM 0.193744450689009 0.394915820504235 no 1293 0.423187992309499 2072 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels.
SGTC_1602 st001878 87.6 µM 0.19305582116346 0.39522746269736 no 1294 0.423457625658408 2023 595405 YLR310C CDC25
SGTC_796 1234-0020 70.7 µM 0.192480313074721 0.395487962731424 no 1295 0.423682993737552 2064 46495034
SGTC_647 0140-0236 81 µM 0.19228381368763 0.395576917616047 no 1296 0.423759948315288 2002 990837
SGTC_153 4077-0274 519.67 µM 0.192237185823547 0.39559802675687 no 1297 0.423778209499411 2078 3121976
SGTC_96 0929-0093 37.281 µM 0.191715989353088 0.395834001130358 no 1298 0.423982340311501 1924 6991579
SGTC_34 0469-0683 81.75 µM 0.189723362015467 0.396736524711916 no 1299 0.424762956526581 2019 3690923
SGTC_1342 1486-1464 234 µM 0.189601627835042 0.396791679937883 no 1300 0.424810655761285 1938 3253938
SGTC_207 4185-0010 4.486 µM 0.188691415135315 0.397204143752313 no 1301 0.425167340225916 2064 3761753
SGTC_2619 obliquin 87.91 µM 0.188657819032665 0.397219370063859 no 1302 0.425180506683177 2029 6708593 A bioactive alkalod. YER133W GLC7
SGTC_957 1187-1561 14.1 µM 0.188511402170201 0.397285730445687 no 1303 0.425237889056082 2083 1538454
SGTC_1642 st009582 77.7 µM 0.18839798278406 0.397337137455093 no 1304 0.425282340445125 2095 6739311
SGTC_2419 paclitaxel 166.5 µM 0.188133855278125 0.397456859395602 no 1305 0.425385861125117 1938 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_3040 9091894 49.47 µM 0.18776395004807 0.3976245437883 no 1306 0.425530848389125 2037 25236966
SGTC_2749 bexarotene 57.39 µM 0.186798617227145 0.398062234764385 no 1307 0.425909265563796 1925 82146 An retinoic acid receptor inhibitor.
SGTC_2874 9043904 71.43 µM 0.185880675096107 0.398478557386324 no 1308 0.426269168564116 1949 4463428
SGTC_692 k241-0027 77.8 µM 0.185265573235205 0.398757594811324 no 1309 0.426510369571391 2072 3600480
SGTC_1500 4488-1866 171 µM 0.184605031181208 0.399057303550742 no 1310 0.426769419730668 2077 2900003
SGTC_1796 st049173 110.4 µM 0.184434906283607 0.399134504221988 no 1311 0.426836144118134 2079 94134
SGTC_2886 9058944 51.95 µM 0.184348116676034 0.399173889841809 no 1312 0.426870184524374 2041 4949929
SGTC_3256 9138902 49.47 µM 0.184169780720743 0.39925482293827 no 1313 0.426940132722834 2048 17228773
SGTC_323 4013-0906 34.3 µM 0.183130368880032 0.399726618808753 no 1314 0.427347863885705 2094 2910086
SGTC_448 monastrol 171 µM 0.182986553467393 0.399791909118343 no 1315 0.427404284629377 2064 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity
SGTC_128 0906-2981 13.371 µM 0.182522754682886 0.400002486757671 no 1316 0.427586249314494 2092 6740226
SGTC_107 0358-0022 2.6945 µM 0.182443984140426 0.400038253680937 no 1317 0.427617155318728 2072 521106 YGL093W | YPR107C SPC105 | YTH1
SGTC_2521 angolensin 13.4 µM 0.182265101651024 0.400119481020037 no 1318 0.427687342380045 1994 821428 A flavenoid.
SGTC_151 3013-0144 2.285 µM 0.182051707746238 0.400216385027508 no 1319 0.427771073473785 2076 906558 YHR107C CDC12
SGTC_339 3091-4833 71.4 µM 0.18070481197767 0.400828163514475 no 1320 0.428299640779797 2017 3240077
SGTC_1758 st042942 75.2445 µM 0.179162900604745 0.401528819389518 no 1321 0.428904896684565 2110 669317
SGTC_650 1328-0195 38 µM 0.17882898415282 0.401680595278955 no 1322 0.429035993028969 2093 2780821
SGTC_1289 0976-0073 69.1 µM 0.178585296675234 0.401791368527481 no 1323 0.429131670218692 2021 3391136
SGTC_1847 st056231 15 µM 0.178582021531331 0.401792857366519 no 1324 0.429132956142289 2067 5393180
SGTC_2784 7567673 72.73 µM 0.178327190290455 0.401908704797154 no 1325 0.429233013136584 2055 3471247
SGTC_1775 st081588 35.1725 µM 0.177018068023888 0.402503973340377 no 1326 0.429747098733303 2079 1426443 YGL099W LSG1
SGTC_3005 9076496 71.4286 µM 0.175648775672309 0.403126843663077 no 1327 0.430284940287011 2115 21368410
SGTC_3200 9114385 49.47 µM 0.172945544935058 0.404357222772677 no 1328 0.431347115665034 1948 17018030 YLR208W SEC13
SGTC_864 0469-0573 172 µM 0.171915289165624 0.404826394857352 no 1329 0.431752063262499 1916 689425
SGTC_1985 st071382 65.5 µM 0.170916924434617 0.405281174536292 no 1330 0.432144544352267 2092 6123237
SGTC_204 PMA1.184 62.41 µM 0.170177790183027 0.405617950805492 no 1331 0.432435158901237 2105 2252213 YGL008C PMA1
SGTC_2854 9024559 71.43 µM 0.169430507326259 0.405958510910717 no 1332 0.432729014501225 1959 3163529
SGTC_2499 avocadenofuran 51.48 µM 0.169126703729513 0.406096984050334 no 1333 0.432848490471931 1906 6857792 A insecticide and lysyl oxidase inhibitor.
SGTC_442 cape 100 µM 0.1683360033058 0.406457438933842 no 1334 0.433159475718262 2106 5281787
SGTC_684 1140-0066 328 µM 0.167150192890098 0.406998160269108 no 1335 0.433625936641667 1991 6813534
SGTC_2032 5185112 25.99 µM 0.167132992930813 0.407006004638488 no 1336 0.433632703252374 2081 5718189
SGTC_712 r015-0009 80.6 µM 0.166676893428651 0.40721403111387 no 1337 0.433812143778194 2066 6813872 YLR060W FRS1
SGTC_1835 st008666 49.2 µM 0.166116076427948 0.407469854997476 no 1338 0.434032801384923 1963 690455
SGTC_1284 0929-0043 16 µM 0.164772521989988 0.408082894969423 no 1339 0.434561516330992 2006 1239883
SGTC_1959 st077091 55.8 µM 0.162988275319881 0.408897362654305 no 1340 0.43526383308357 2043 821356 YKL052C ASK1
SGTC_3109 9122853 49.47 µM 0.162950557288433 0.40891458433045 no 1341 0.435278681900875 2056 1234709
SGTC_2883 9059145 45.46 µM 0.16284256623538 0.408963892938202 no 1342 0.435321196273705 2022 16476510
SGTC_2746 daunorubicin 9.88 µM 0.162678396957542 0.409038855227341 no 1343 0.435385828558847 2105 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_3170 9103054 49.47 µM 0.162211666014864 0.409251990124155 no 1344 0.435569586658266 2010 16432970
SGTC_943 3253-1379 105 µM 0.159864078475858 0.410324432720648 no 1345 0.436494072878549 2071 668464
SGTC_1412 3909-8563 178 µM 0.158784386637209 0.410817891413076 no 1346 0.436919375199194 2141 23767530
SGTC_1334 1486-0610 236 µM 0.156890383314676 0.411683860865511 no 1347 0.437665619501061 2075 3742339
SGTC_1018 4259-0013 28.1 µM 0.156750031868176 0.411748049032038 no 1348 0.437720927347462 2017 6801262
SGTC_1840 st055363 71 µM 0.154978452611412 0.412558463510769 no 1349 0.43841915218759 1959 676033
SGTC_3186 9110464 49.47 µM 0.154621759675538 0.412721679022155 no 1350 0.438559757282165 2117 17018021
SGTC_686 1319-0111 510 µM 0.154515638553388 0.412770240826702 no 1351 0.438601590756 2123 4562600
SGTC_1978 st071761 42 µM 0.154380908522518 0.412831896201262 no 1352 0.43865470299208 1980 5147680
SGTC_1167 k781-0610 148 µM 0.15431107807571 0.412863852969459 no 1353 0.43868223144824 2026 4525169
SGTC_3149 9097855 49.47 µM 0.153846170976895 0.413076624852276 no 1354 0.438865513997082 2125 25236625 YMR079W SEC14
SGTC_117 lucigenin 22.078 µM 0.153456461274599 0.41325500116723 no 1355 0.439019161218721 1906 65100 An acridine derivative; a dye stuff and potential carcinogen.
SGTC_3224 9130643 49.47 µM 0.15317671314878 0.413383057366989 no 1356 0.439129460578661 2065 17644395
SGTC_3313 9133968 57.047 µM 0.15308200634948 0.413426411998999 no 1357 0.439166802737865 2089 1494643
SGTC_2083 5306046 65.942 µM 0.153056003514172 0.413438315693965 no 1358 0.439177055549656 2028 539837
SGTC_1356 1502-0781 85.8 µM 0.152896262605107 0.413511444351489 no 1359 0.439240041632925 2009 567702
SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM 0.152847454671856 0.413533788998586 no 1360 0.439259286982102 2130 688798
SGTC_546 peri-Naphthalide 147 µM 0.152201969782753 0.413829323256008 no 1361 0.439513820201697 2094 223824 A penicillin ester.
SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM 0.150473983039978 0.414620719114226 no 1362 0.440195337770906 2106 23847180
SGTC_1320 1313-0481 95.3 µM 0.150430376492776 0.414640694854086 no 1363 0.440212538483997 2123 6813365 YLR208W SEC13
SGTC_2037 5169046 200 µM 0.149816154567521 0.414922087440095 no 1364 0.440454831852533 2064 5718022
SGTC_3110 9122132 49.47 µM 0.149202068247073 0.415203461543871 no 1365 0.440697094018338 2118 918317
SGTC_1725 st036284 20.55 µM 0.14869236722762 0.415437039386049 no 1366 0.440898192176279 2133 707914
SGTC_1355 1499-0035 1.68 µM 0.14707952484515 0.416176344193216 no 1367 0.441534625457142 2033 1548538
SGTC_2647 atorvastatin 60.16 µM 0.146781288507665 0.416313084217251 no 1368 0.441652327155294 2110 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7
SGTC_2197 6588183 93.1375 µM 0.146758974052612 0.416323315702378 no 1369 0.441661133966372 2078 884136
SGTC_2608 thymoquinone 42.66 µM 0.14633498080248 0.416517733216275 no 1370 0.44182847619467 2167 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC).
SGTC_548 1436-0017 110 µM 0.145789418699515 0.416767924852907 no 1371 0.442043814653254 2157 9677137
SGTC_1539 benzyladenosine 56 µM 0.145566505910774 0.416870161081746 no 1372 0.4421318053459 2077 92208 A nucleotide analog.
SGTC_713 1488-1073 324 µM 0.144269218865828 0.417465257303276 no 1373 0.442643941890976 2158 3312542
SGTC_2591 skatole 100 µM 0.143909842229856 0.417630145362768 no 1374 0.442785831808597 2045 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite.
SGTC_343 4130-2827 29.8 µM 0.142764090526055 0.418155932120844 no 1375 0.443238249061862 2018 1118244
SGTC_909 3448-9333 149 µM 0.142440931710271 0.418304256559912 no 1376 0.443365866575609 2035 3344074
SGTC_3269 9137823 49.47 µM 0.14225735397245 0.418388520817391 no 1377 0.443438365233027 1995 17682936
SGTC_2260 7964312 200 µM 0.141541959297421 0.418716930766733 no 1378 0.443720907476288 2154 231951
SGTC_2690 usnic acid 100 µM 0.141040667407401 0.418947088205504 no 1379 0.443918907744472 2133 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_3098 9119039 49.47 µM 0.140867726799865 0.419026496623315 no 1380 0.443987219075198 2185 17161528
SGTC_2012 4023501 200 µM 0.140159254801815 0.419351837161327 no 1381 0.444267082009015 2034 3477460
SGTC_2348 9022543 33.42 µM 0.139742125702268 0.419543414653538 no 1382 0.444431870722164 2071 3162678 YDL140C RPO21
SGTC_1043 0916-0009 19.3 µM 0.13825315823091 0.420227417302075 no 1383 0.4450201721156 2213 3101130
SGTC_1050 3232-1156 69.3 µM 0.138223321003591 0.420241126412865 no 1384 0.445031962253539 2022 700529
SGTC_486 niguldipine 82 µM 0.137177358060331 0.420721769028539 no 1385 0.445445303678899 2116 1236 A calcium channel blocker.
SGTC_3216 9129716 49.47 µM 0.137123418966728 0.420746558420944 no 1386 0.445466620827894 2071 8056934
SGTC_1201 1889-3372 45.9 µM 0.136064452282065 0.421233303113197 no 1387 0.445885164548886 2049 5392199
SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM 0.135591275204772 0.421450833746085 no 1388 0.446072201564623 2112 688761
SGTC_762 1165-0429 115 µM 0.135537432705325 0.421475587930137 no 1389 0.446093485141305 2176 5967793
SGTC_139 0099-0334 718.624 µM 0.134908266255893 0.421764871290904 no 1390 0.446342201888696 2194 97690
SGTC_1020 4335-0961 93.3 µM 0.13349800429115 0.422413446383148 no 1391 0.446899771244917 1969 669075
SGTC_2625 euphol 100 µM 0.132992336826701 0.422646052620779 no 1392 0.447099720495439 2188 6708538 A triterpene alcohol.
SGTC_3267 9137951 49.47 µM 0.132386841610144 0.422924614949956 no 1393 0.447339160971368 2029 16643986
SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM 0.130553469238255 0.423768305263741 no 1394 0.448064276871525 2191 1241132 A phosphatase inhibitor.
SGTC_953 1188-0045 9.7 µM 0.130427819258068 0.423826140332939 no 1395 0.448113978995511 2109 6144426
SGTC_1879 gemcitabine 100 µM 0.129632740894228 0.42419214266442 no 1396 0.448428499158299 2143 60750 A nucleoside analog which inhibits DNA replication.
SGTC_1559 coumarin 343 70.1 µM 0.129108388261854 0.424433556291193 no 1397 0.448635942345294 2140 108770 A hepatotoxic, DNA x-linker.
SGTC_1686 st019653 115.5 µM 0.12888965411074 0.424534270578607 no 1398 0.448722481603379 2181 97252
SGTC_2602 kawain 100 µM 0.128085452417248 0.424904600749019 no 1399 0.449040674252722 2209 5369129
SGTC_1455 4262-0120 131 µM 0.127231285133831 0.425298012365796 no 1400 0.449378672315539 2141 1529587
SGTC_1200 1643-0193 18.4 µM 0.126937079912274 0.425433534393056 no 1401 0.449495099240758 2186 5403974
SGTC_1930 st074634 34.3 µM 0.126573757542042 0.425600906543897 no 1402 0.44963888415124 2167 684253 YOR116C RPO31
SGTC_2274 7947094 46.08 µM 0.12656093772658 0.42560681250867 no 1403 0.449643957717004 2213 2971028
SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM 0.125362629411671 0.426158935058533 no 1404 0.450118236038743 2048 6857784
SGTC_3014 9081533 49.47 µM 0.125050994779647 0.42630254499731 no 1405 0.450241589578609 2196 21367265
SGTC_2222 6885208 172.143 µM 0.124276339696572 0.426659569986953 no 1406 0.450548240121789 2138 609514
SGTC_1287 0971-0001 34.6 µM 0.123570063090897 0.42698513291659 no 1407 0.450827848484625 2102 4665869
SGTC_736 0958-0254 92.6 µM 0.122182881200841 0.427624708285893 no 1408 0.451377091846301 2138 6812352
SGTC_932 2857-0803 154 µM 0.121736874359236 0.427830385110134 no 1409 0.451553704448289 2178 674898
SGTC_1938 st074717 56.4 µM 0.121329891948909 0.428018082865018 no 1410 0.45171487227839 2185 17250979
SGTC_3347 9188721 44.724 µM 0.121145662982399 0.428103053475893 no 1411 0.451787830832885 2104 44118411 YKL104C | YBL026W GFA1 | LSM2
SGTC_1736 st036774 51 µM 0.12100321294481 0.42816875697539 no 1412 0.451844245167216 2215 1272247
SGTC_1276 0871-0068 94.2 µM 0.120710441620176 0.428303800751368 no 1413 0.451960194130108 2166 3414906
SGTC_1348 1493-0373 93.8 µM 0.119178119877532 0.429010736490733 no 1414 0.452567120449089 2142 3010129
SGTC_2909 7941780 10.49 µM 0.118232578780976 0.429447075111549 no 1415 0.452941688426898 2195 1243215
SGTC_2177 5811945 192 µM 0.115987966998517 0.430483239861684 no 1416 0.453831039185275 2162 5343475
SGTC_1452 4194-0072 190 µM 0.115143454862509 0.430873210561072 no 1417 0.454165708467676 2195 1343545
SGTC_1506 4226-2149 212 µM 0.114906023734844 0.430982861382507 no 1418 0.454259805236827 2102 991114
SGTC_2264 7948757 110.76 µM 0.112120540093987 0.432269652989737 no 1419 0.455363915735897 2176 2971411
SGTC_1623 st003709 20.3 µM 0.112110556624983 0.432274266288285 no 1420 0.455367873610419 2069 16192618
SGTC_632 0781-2353 4.65 µM 0.111846675164224 0.432396207605545 no 1421 0.455472489123448 2141 6811515 YHR007C ERG11
SGTC_1316 1272-0050 65.9 µM 0.111462200498523 0.432573887340534 no 1422 0.45562491920386 2186 7340392
SGTC_602 3130-1533 38.1 µM 0.111443762656801 0.432582408481097 no 1423 0.45563222929507 2194 720941
SGTC_2412 st077135 33.4 µM 0.111062596371024 0.432758573400581 no 1424 0.455783354482832 2158 13258915
SGTC_3030 9087619 49.47 µM 0.109412460726453 0.433521375945992 no 1425 0.45643767542655 2167 25236973
SGTC_2018 5133068 143 µM 0.107678495296756 0.434323197050477 no 1426 0.457125364290491 2173 785362
SGTC_1216 1165-0504 9.65 µM 0.107380258774708 0.434461135053656 no 1427 0.457243657580531 2222 6304004
SGTC_2157 5649910 96.377 µM 0.107301542603578 0.434497543567676 no 1428 0.457274880394499 2115 2858091
SGTC_3180 9109287 49.47 µM 0.107078058056223 0.434600914684502 no 1429 0.457363527103684 2148 18891271
SGTC_1631 benzylvanillin 81.9 µM 0.106190689529775 0.435011404456887 no 1430 0.457715528928839 2126 75506
SGTC_1582 3',3',6'-trihydroxyflavone 74 µM 0.1059033040809 0.435144361767515 no 1431 0.457829536267754 2092 688803
SGTC_1204 4049-0315 18.3 µM 0.105193937969651 0.435472577489266 no 1432 0.458110960417378 2171 588402
SGTC_2026 5148700 152 µM 0.105006818179758 0.435559163130922 no 1433 0.458185199254162 2153 79838
SGTC_1819 st053448 58.6 µM 0.104456972344739 0.435813610277711 no 1434 0.458403356258808 2142 2857616
SGTC_1487 3970-0795 2.82 µM 0.104367374304005 0.435855075267056 no 1435 0.458438906394331 2152 3765103
SGTC_3222 9128301 49.47 µM 0.104239281220972 0.435914356563753 no 1436 0.458489730922949 2159 4911358
SGTC_1937 st074714 47.2 µM 0.103756796195102 0.436137662862839 no 1437 0.458681176494586 2215 17250970
SGTC_2624 nerol 100 µM 0.103257662351655 0.436368696080232 no 1438 0.458879238247683 2190 637566 A natural product oil.
SGTC_88 0180-0332 8.668 µM 0.101995475183684 0.436953019156262 no 1439 0.459380133317419 2237 3101745
SGTC_2553 4-methylesculetin 85.09 µM 0.10167368304377 0.437102013235284 no 1440 0.459507845879582 2176 5319502
SGTC_1240 0356-0016 42.1 µM 0.10158892938422 0.437141256802144 no 1441 0.459541483528095 2153 4305613
SGTC_2852 9023854 51.95 µM 0.101547022436098 0.437160661244368 no 1442 0.459558115969328 2187 19798528
SGTC_2770 toltrazuril 17.5 µM 0.100940102960333 0.437441703975817 no 1443 0.459799004053597 2241 68591 Kills coccidiodes.
SGTC_1301 naphtanilide LB 4.81 µM 0.100720225519941 0.437543529161964 no 1444 0.459886277687997 2226 67238 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_1741 st038134 10.228 µM 0.0996142162738025 0.43805578435969 no 1445 0.460325303506004 2184 1272587
SGTC_2501 sodium tetradecyl sulfate 13.37 µM 0.0994250770836391 0.438143395793797 no 1446 0.460400386387139 2223 23665772 A membrane-active detergent.
SGTC_2474 5321570 43.32 µM 0.0992554535998011 0.438221969908655 no 1447 0.460467723288729 2212 2841384
SGTC_94 0334-0113 514.748 µM 0.0989792072146167 0.438349939802433 no 1448 0.460577389631485 2214 6795178
SGTC_1674 st016616 23.6 µM 0.0988367927611225 0.438415915175759 no 1449 0.460633927551447 2220 625830
SGTC_3162 9099653 49.47 µM 0.0986632643042337 0.438496306834438 no 1450 0.460702818671227 2224 25237511
SGTC_148 3253-0744 288.01 µM 0.0975384380242746 0.439017473828275 no 1451 0.461149405305394 2257 6893655
SGTC_382 3229-0966 23.2 µM 0.0966539833504566 0.439427343487328 no 1452 0.461500592312285 2225 5722370
SGTC_2144 5628481 200 µM 0.0961347235202171 0.439668006622692 no 1453 0.4617067868156 2160 2818399
SGTC_2370 9071495 200 µM 0.0946024798672613 0.440378290488787 no 1454 0.462315290011689 2077 21791103
SGTC_1512 0259-0544 12.2 µM 0.0942772613616524 0.440529072906339 no 1455 0.46244445612799 2132 18476
SGTC_1009 4106-0057 9.87 µM 0.0937711513475623 0.440763739955988 no 1456 0.462645474286602 2249 2928005
SGTC_1878 temozolomide 1 mM 0.0937595707096683 0.440769109771689 no 1457 0.462650074027851 2255 5394 DNA alkylating agent.
SGTC_1391 3442-0225 151 µM 0.0924522483162426 0.441375370710593 no 1458 0.463169364493643 2178 5227075
SGTC_229 benomyl 22.8748 µM 0.0920707608679586 0.44155230860753 no 1459 0.463320909600762 2151 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C
SGTC_1816 st051957 91.6 µM 0.0915256188609 0.441805171448226 no 1460 0.463537475378555 2204 674121
SGTC_2839 9003951 25.97 µM 0.0909804842106008 0.442058054594012 no 1461 0.463754049039248 2306 2990634
SGTC_2813 7971799 71.43 µM 0.090751728687168 0.442164179299407 no 1462 0.463844933313892 2176 2234054
SGTC_1934 st074720 32.6 µM 0.0907311433163639 0.442173729508183 no 1463 0.463853111947786 2231 17250992
SGTC_354 2783-3500 4.88 µM 0.0888079346848681 0.443066114713671 no 1464 0.464617275822052 2119 6740761
SGTC_2361 9034121 116 µM 0.0879587704333333 0.443460226369722 no 1465 0.464954722754509 2151 6496917
SGTC_3166 9102297 49.47 µM 0.0878787866423049 0.443497351103871 no 1466 0.464986508585136 2157 25237072
SGTC_1174 0739-0097 51.1 µM 0.0871265018345278 0.443846550743864 no 1467 0.465285480031888 2157 728447
SGTC_2516 gossypol 71.55 µM 0.0865434410508086 0.444117229067491 no 1468 0.46551721231141 2243 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_2049 5262831 67.185 µM 0.0863651505591122 0.444200003300734 no 1469 0.465588074606553 2180 763417
SGTC_2547 epiafzelechin trimethyl ether 100 µM 0.0859045753058906 0.444413844038999 no 1470 0.465771137195303 2258 6708630 An antioxidant.
SGTC_2601 securinine 100 µM 0.0853213530138425 0.444684651849276 no 1471 0.466002958089687 2185 442872 A GABA receptor antagonist.
SGTC_1012 4112-3522 18 µM 0.0845338689593483 0.445050345542942 no 1472 0.466315987833388 2250 3112398
SGTC_2670 beta-carotene 100 µM 0.084272885125184 0.445171552162065 no 1473 0.466419735115918 2262 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.)
SGTC_1313 1220-0047 237 µM 0.0839766510694242 0.445309135967948 no 1474 0.466537497964645 2181 3528706
SGTC_608 k048-0125 159 µM 0.0836694723313714 0.445451809910799 no 1475 0.466659614780895 2250 6817652 YLR060W | YFL022C FRS1 | FRS2
SGTC_2206 7254556 146.969 µM 0.083469650677872 0.445544623979756 no 1476 0.466739054204625 2252 4398905
SGTC_2440 5628896 157.78 µM 0.0834643602727066 0.445547081331748 no 1477 0.466741157431832 2198 5522048
SGTC_216 k038-0035 28.382 µM 0.0830908632227926 0.445720573084089 no 1478 0.466889645408054 2250 4444231 YPR107C YTH1
SGTC_761 k216-0224 480 µM 0.0827923447754105 0.445859244274538 no 1479 0.467008328107348 2283 1340404
SGTC_1428 4049-0204 61.7 µM 0.0815828290570644 0.446421169904172 no 1480 0.46748922809963 2259 X1428
SGTC_1264 0783-0040 158 µM 0.0815151711219574 0.446452606109449 no 1481 0.467516130109257 2201 2855798
SGTC_249 wiskostatin 11.211 µM 0.0813683794913721 0.446520811710125 no 1482 0.467574497606842 2257 2775510 A n-wasp and actin depolymerizer.
SGTC_2688 kanamycin b 96.69 µM 0.0813007961086615 0.446552214340446 no 1483 0.46760137044235 2176 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis.
SGTC_3229 9132204 49.47 µM 0.0807364760820487 0.44681443880256 no 1484 0.467825763886356 2181 17682924
SGTC_2498 4'-Methoxychalcone 54.63 µM 0.0803709007651462 0.446984324319668 no 1485 0.467971134921369 2234 641818 YHR062C RPP1
SGTC_1592 4',5'-dihydroxyflavone 8.85 µM 0.0799995219437734 0.447156916729273 no 1486 0.468118818093539 2230 688669
SGTC_2129 girgensonine 121.053 µM 0.0799359509828864 0.44718646132789 no 1487 0.468144098276925 2203 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_705 1124-0212 310 µM 0.0799116558831924 0.447197752550803 no 1488 0.46815375971234 2272 9554485
SGTC_2247 cerulenin 830 nM 0.0798560629792204 0.447223589686293 no 1489 0.468175867420161 2245 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12
SGTC_2427 5545055 42.75 µM 0.0793952418625763 0.447437767676695 no 1490 0.468359126569944 2205 5372858
SGTC_466 geldanamycin 89.2 µM 0.078714709810004 0.447754089763223 no 1491 0.468629772524368 2282 5288382 HSP90 inhibitor.
SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM 0.0770157924822581 0.448543918064894 no 1492 0.469305490849034 2250 5711223 A potent inhibitor of glutathione S-transferases.
SGTC_1404 3909-7820 48.3 µM 0.0750087068228086 0.44947727674497 no 1493 0.470103892184039 2266 23741373
SGTC_2914 7968218 45.32 µM 0.0749596888497717 0.449500075180397 no 1494 0.470123392626961 2247 2977111
SGTC_2769 toremifene 3.73 µM 0.0741867725988926 0.449859583296218 no 1495 0.47043088539193 2236 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_3307 9126885 69.2785 µM 0.0734983930623735 0.450179805336192 no 1496 0.47070476138431 2236 24824909
SGTC_3126 9127922 49.47 µM 0.0728731565168941 0.45047068248627 no 1497 0.470953527565188 2204 45595682
SGTC_648 0375-0473 33.3 µM 0.0720618113935183 0.450848182081226 no 1498 0.471276358636655 2214 1713139
SGTC_114 0364-0001 490.298 µM 0.0720438158582509 0.450856555481217 no 1499 0.471283519204954 2134 4003655
SGTC_72 0744-0168 198.391 µM 0.0720305432931613 0.450862731276876 no 1500 0.471288800471361 2146 677577
SGTC_2557 derrustone 83.84 µM 0.0711188857233337 0.451286958819777 no 1501 0.471651568797441 2108 629853 An antioxidant.
SGTC_2962 9082311 13.18 µM 0.0706773136693159 0.451492458446687 no 1502 0.471827288371992 2215 16459453
SGTC_2143 5623677 140.463 µM 0.0704894620234339 0.451579885141056 no 1503 0.471902043887206 2276 5375313
SGTC_991 3996-0057 64.7 µM 0.0701014884614641 0.451760456578009 no 1504 0.472056440999041 2214 715343
SGTC_665 3914-0008 307 µM 0.0699491740970671 0.451831349766724 no 1505 0.472117056840203 2243 1069549
SGTC_2110 5483698 200 µM 0.0695204586916084 0.452030899278597 no 1506 0.47228767418429 2205 2848765 YHR062C RPP1
SGTC_3039 9090270 49.47 µM 0.0684288308844599 0.452539062039968 no 1507 0.472722135943075 2291 17173750
SGTC_1241 0364-0022 50.8 µM 0.0669102896215424 0.453246086060285 no 1508 0.473326560732234 2232 4563895
SGTC_231 b-estradiol 524 µM 0.0666847327219077 0.453351116744963 no 1509 0.473416344389159 2257 450 A steroid.
SGTC_566 0958-0068 16.5 µM 0.0660602361411192 0.453641930896657 no 1510 0.473664934314259 2272 6815365
SGTC_2503 beta-caryophyllene alcohol 24.72 µM 0.0658479512217515 0.453740792925917 no 1511 0.473749439747021 2144 61125 An anti-inflammatory.
SGTC_2827 7993847 71.43 µM 0.0657710305796769 0.453776615918215 no 1512 0.473780060264496 2232 2985692
SGTC_1844 rapamycin 4 nM 0.0651094793585603 0.454084724841816 no 1513 0.474043416506373 2205 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2
SGTC_275 trichlorophene 5.69 µM 0.064751256869511 0.454251573876777 no 1514 0.474186025668475 2218 62616
SGTC_2862 9027634 71.43 µM 0.0645062879618992 0.454365677521239 no 1515 0.474283550235912 2266 5012562
SGTC_308 4092-1169 104 µM 0.0640767209019374 0.454565773906947 no 1516 0.474454568887566 2255 2268590 YDL196W YDL196W
SGTC_2057 5236571 38.335 µM 0.063840493869628 0.454675815602306 no 1517 0.47454861727941 2266 54684039 YBR257W POP4
SGTC_1633 st005664 67.9 µM 0.063746517519865 0.454719593595585 no 1518 0.474586032209054 2276 2063822
SGTC_1750 st081859 2.357 µM 0.0634158196440795 0.454873650441181 no 1519 0.474717695175953 2244 5291695
SGTC_1771 st048882 4.1505 µM 0.0632986856361385 0.454928219387091 no 1520 0.474764331188396 2242 4580403
SGTC_464 bw-b 70c 158 µM 0.0626243300424818 0.455242396360082 no 1521 0.475032827434001 2287 5353454
SGTC_2270 7924575 90.91 µM 0.0620788627064025 0.455496545796537 no 1522 0.47525001482161 2308 1262135
SGTC_248 streptozotocin 5.23457 mM 0.0619367321146103 0.455562771657065 no 1523 0.475306607820213 2296 5300 DNA alkylating agent.
SGTC_924 2046-0044 21.3 µM 0.0619256333318401 0.455567943195587 no 1524 0.475311027110758 2305 3623589
SGTC_2610 ononetin 44.17 µM 0.0618552182542646 0.455600753661394 no 1525 0.475339064912575 2230 259632
SGTC_3099 9120367 49.47 µM 0.060339592519254 0.456307044572565 no 1526 0.475942584552903 2306 24824940
SGTC_2881 9058953 51.95 µM 0.0593171644094299 0.456783580485585 no 1527 0.476349744982286 2289 17122249
SGTC_452 diindolylmethane 8 µM 0.0579409987415814 0.457425085315968 no 1528 0.476897812843134 2273 3071 Inhibits expression of several cancer promoting factors.
SGTC_1127 asiatic acid 681.4 nM 0.0578511269673628 0.457466983260732 no 1529 0.476933606454104 2265 470603 A kinase inhibitor which arrests cells at G2/M.
SGTC_1067 clotrimazole 1.36 µM 0.0558841943162639 0.458384078795341 no 1530 0.477717031129926 2241 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_1651 st011928 86.1 µM 0.0536104148682436 0.459444519521663 no 1531 0.478622779290907 2281 720198
SGTC_3228 9131799 49.47 µM 0.0533859887144413 0.459549202715391 no 1532 0.478712184339512 2234 17015818
SGTC_2483 5729050 27.16 µM 0.0520766727088471 0.460159986592983 no 1533 0.479233800110345 2297 2865180
SGTC_1669 st015249 58.4 µM 0.0501208944332882 0.461072513855813 no 1534 0.480013024656139 2330 722793
SGTC_1874 staurosporine 7.6 µM 0.0494318788933467 0.461394043891113 no 1535 0.480287561761955 2294 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1
SGTC_701 4424-0219 185 µM 0.0494055204945095 0.461406344576156 no 1536 0.480298064409038 2322 2911779
SGTC_407 eburnamonine 100 µM 0.048682825372272 0.461743619355697 no 1537 0.480586031506458 2308 3195
SGTC_3134 9127454 49.47 µM 0.0472217474793781 0.462425573979058 no 1538 0.481168247436229 2329 24262820
SGTC_1016 4226-1401 38 µM 0.0467516586573825 0.462645010400204 no 1539 0.481355578836493 2326 2901613
SGTC_1077 5-fluorocytosine 377 nM 0.0465131278775377 0.462756360392126 no 1540 0.481450635439218 2267 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_3268 9137683 49.47 µM 0.0440080816476267 0.463925930736741 no 1541 0.482448980943519 2315 1953228
SGTC_1453 4237-0541 195 µM 0.0433896856981117 0.464214699361866 no 1542 0.482695449789983 2330 739892
SGTC_2663 amphotericin b 100 µM 0.0431744677405123 0.464315202822709 no 1543 0.482781228948279 2326 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_3348 9149464 3.537 µM 0.0418454157874459 0.464935899752674 no 1544 0.483310965068165 2339 1951442
SGTC_1418 3966-3099 2.4 µM 0.0417168263489507 0.464995958442275 no 1545 0.483362220075468 2320 740335
SGTC_2402 5553605 200 µM 0.0396218828597107 0.465974529310728 no 1546 0.48419729056836 2300 6758546
SGTC_1147 3809-1045 12.3 µM 0.0387031682635708 0.466403736133409 no 1547 0.484563523697302 2313 325925
SGTC_2289 7946404 165.07 µM 0.0364565855554876 0.467453462490221 no 1548 0.485459147693207 2309 1246120 YPR165W RHO1
SGTC_1932 st074806 40.9 µM 0.0354745722884199 0.467912384353164 no 1549 0.485850660992029 2293 17251235
SGTC_504 lovastatin 124 µM 0.0334532563348058 0.468857134569907 no 1550 0.486656570494617 2306 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1
SGTC_2027 5150920 200 µM 0.0334255687197743 0.468870076814845 no 1551 0.486667610080969 2318 786715
SGTC_2629 bisabolol 100 µM 0.033163125140828 0.468992754562924 no 1552 0.486772251906015 2312 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer.
SGTC_1777 st045864 34.765 µM 0.0326321993888104 0.469240941755347 no 1553 0.486983946049116 2354 4691462
SGTC_503 tyrphostin 8 294 µM 0.0309818433835153 0.470012495054875 no 1554 0.48764200980135 2339 92970 A tyrosine kinase inhibitor. YOR207C RET1
SGTC_832 4083-0019 164 µM 0.0306080102718563 0.470187280468249 no 1555 0.487791076935545 2319 1990758
SGTC_1215 3852-0577 11.2 µM 0.030464898037489 0.470254194016906 no 1556 0.487848143843691 2345 2884876
SGTC_1056 3448-1962 115 µM 0.0302256642049821 0.470366052049545 no 1557 0.487943540401744 2317 715507
SGTC_2325 6158266 200 µM 0.0298524378340815 0.470540565342688 no 1558 0.488092369017895 2309 3623240
SGTC_197 4544-0043 41.561 µM 0.0296476150339328 0.47063633885274 no 1559 0.488174045340334 2350 896523
SGTC_1707 st032323 6.317 µM 0.0294969904855743 0.470706770776011 no 1560 0.488234109571623 2346 3132057 YMR211W DML1
SGTC_2366 9070441 60.58 µM 0.0289167298471171 0.470978108750525 no 1561 0.488465501356358 2359 6837235
SGTC_978 1416-0512 87.4 µM 0.0288346323023938 0.471016499799357 no 1562 0.488498239886436 2324 6814003
SGTC_1059 3448-6867 171 µM 0.0287638545188029 0.471049597635672 no 1563 0.488526464429723 2372 3934407
SGTC_2090 5301565 104.445 µM 0.0283828626556057 0.471227764405359 no 1564 0.488678396157533 2350 2056344
SGTC_768 0384-0033 77.3 µM 0.0276187884721944 0.471585092844079 no 1565 0.4889830981736 2321 3965305 YMR134W ERG29
SGTC_2175 5807670 165.306 µM 0.0262770777445999 0.472212615104676 no 1566 0.489518168953691 2357 241186
SGTC_2184 6075246 200 µM 0.0256500766743734 0.472505889191308 no 1567 0.489768221890901 2322 2267320
SGTC_1905 st060207 84.5 µM 0.023034989886453 0.473729231341508 no 1568 0.490811181227211 2335 1948547
SGTC_3050 9093513 49.47 µM 0.0221890264648341 0.474125028103638 no 1569 0.491148585524782 2374 25236664
SGTC_1248 0469-0687 58.6 µM 0.0219676599550621 0.47422860200031 no 1570 0.49123687646334 2335 4017482
SGTC_2993 9054257 71.4286 µM 0.0216794750581304 0.474363441774866 no 1571 0.491351818228094 2379 6470217 YGL055W OLE1
SGTC_826 1683-5028 118 µM 0.0213146087569859 0.474534164473624 no 1572 0.491497345191958 2342 722377
SGTC_1584 6-fluoro-dl-tryptophan 90 µM 0.0202512055625938 0.475031762509847 no 1573 0.49192149005716 2362 94937 An inhibitor of serotonin biosynthesis.
SGTC_1381 2324-0066 62.1 µM 0.0193158764097602 0.475469463107011 no 1574 0.492294559374058 2350 10885928
SGTC_885 0865-0106 16.8 µM 0.0178436687131149 0.476158463432394 no 1575 0.492881783850734 2362 2793380
SGTC_2938 9059746 27.26 µM 0.0173705280117529 0.476379910806126 no 1576 0.493070510423504 2360 6471769
SGTC_3128 9127691 49.47 µM 0.0169912296357783 0.476557441767096 no 1577 0.493221806250066 2349 41316314
SGTC_1817 st052116 64.4 µM 0.0163546187097793 0.476855418549617 no 1578 0.493475741962534 2364 4361398
SGTC_1133 3473-0247 50 µM 0.0140041501809461 0.477955706909915 no 1579 0.494413334998265 2351 711311
SGTC_662 k832-1615 104 µM 0.0139636012439801 0.477974689953208 no 1580 0.494429510102057 2365 5878478
SGTC_2958 9077254 16.72 µM 0.0136583382526413 0.478117600863794 no 1581 0.49455128080147 2354 16457351
SGTC_2045 5106652 78.05 µM 0.0130670330961937 0.478394432314268 no 1582 0.494787156365488 2378 673349
SGTC_2504 purpurogallin 52.29 µM 0.0121030170160427 0.478845778201399 no 1583 0.495171712669189 2368 5281571 An antioxidant.
SGTC_2013 4024628 200 µM 0.0120965710179906 0.478848796266566 no 1584 0.495174284062112 2374 5230760
SGTC_2127 5253358 187.912 µM 0.0113013308254424 0.479221143005058 no 1585 0.495491517279759 2386 20612
SGTC_2942 9052777 62.25 µM 0.00885889823269371 0.480364848854359 no 1586 0.4964658571639 2383 6469503
SGTC_1109 tnp00067 928.257 nM 0.00739002746018496 0.481052748165193 no 1587 0.497051832427299 2378 676295
SGTC_1403 3909-7815 62.9 µM 0.00614071977214635 0.481637866512052 no 1588 0.497550222647017 2390 6615483
SGTC_620 0109-0052 432 µM 0.00595717458192233 0.481723834012835 no 1589 0.497623445244048 2390 493037
SGTC_2441 5730946 39.09 µM 0.00589377366104646 0.48175352945183 no 1590 0.497648738107962 2386 1774275
SGTC_1003 4049-0218 100 µM 0.00578329971534799 0.481805272984883 no 1591 0.497692810084581 2388 295161
SGTC_1880 MG-132 525 µM 0.00554269828668763 0.481917966389168 no 1592 0.497788794627863 2397 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1
SGTC_365 0121-0052 13.6 µM 0.004914742933691 0.48221209622477 no 1593 0.498039309139766 2392 3101739
SGTC_82 0054-0107 293.755 µM 0.00487807591247275 0.482229271098299 no 1594 0.498053936989474 2391 3104697
SGTC_2606 farnesol 9.78 µM 0.00426048062170612 0.482518558350188 no 1595 0.498300319287186 2395 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_2940 9060638 45.86 µM 0.00381137670970629 0.482728928496457 no 1596 0.49847948436528 2396 4027022
SGTC_3178 9107506 49.47 µM 0.00312107906482062 0.483052288445449 no 1597 0.498754871622061 2395 8897194
SGTC_1198 1612-1005 86.7 µM 0.002831820227971 0.483187790891154 no 1598 0.498870268690491 2388 6998509
SGTC_2818 7996756 12.99 µM 0.00243455969186313 0.483373889574728 no 1599 0.499028752164199 2403 2241621
SGTC_1646 st011709 75.6 µM 0.00224081405449659 0.483464652003417 no 1600 0.499106045279272 2401 5757843
SGTC_884 0851-0618 334 µM 0.00217487872067069 0.483495540383787 no 1601 0.499132349607591 2400 9642473
SGTC_894 0960-0238 55.9 µM 0.00199056193055998 0.483581886829603 no 1602 0.49920588120857 2385 6741907 YDL195W SEC31
SGTC_2105 5350118 200 µM 0.00193274256506939 0.483608973488311 no 1603 0.499228947753706 2399 2133313
SGTC_568 1193-0097 7.48 µM 0.00149729753224585 0.483812968999013 no 1604 0.499402664931241 2401 3646150
SGTC_2711 st079103 59.1 µM 0.00137487834042073 0.483870320207419 no 1605 0.499451503072401 2399 54693780
SGTC_2313 7726885 200 µM 0.0013406577526207 0.483886352002317 no 1606 0.49946515509915 2404 726423
SGTC_739 1486-1183 203 µM 0.000138466650926491 0.484449575540243 no 1607 0.499944759798696 2405 4346692
SGTC_554 4483-2211 187 µM 0 0.484514448835377 no 1608 0.5 2406 747107
SGTC_2425 5628681 7.85 µM 0 0.484514448835377 no 1609 0.5 2405 5714958
SGTC_2849 9019321 12.99 µM -5.98317795455894e-05 0.484542480872275 no 1610 0.499976130573442 2407 16489627
SGTC_2833 9001315 45.46 µM -0.000115824267977512 0.484568714216062 no 1611 0.499953792802511 2408 2989378
SGTC_866 0495-0101 262 µM -0.000378803066879687 0.484691924728033 no 1612 0.49984887944429 2407 635694
SGTC_1149 3909-7961 23.3 µM -0.000617972505594489 0.484803981376481 no 1613 0.499753464655084 2405 735261
SGTC_1191 1487-1166 10.6 µM -0.000682898942946727 0.484834401185246 no 1614 0.499727562759592 2411 3955771
SGTC_298 1391-0729 10 µM -0.000912976666624347 0.484942199590592 no 1615 0.499635775057262 2408 3237558
SGTC_1279 0874-0590 65.2 µM -0.00134685540097643 0.485145487950814 no 1616 0.499462682597414 2410 3523074
SGTC_553 k007-0256 45.7 µM -0.00208970185745452 0.485493548140338 no 1617 0.49916633018238 2413 6287000
SGTC_2099 5377090 177.372 µM -0.00210728571779169 0.485501787180794 no 1618 0.499159315252485 2416 2243829
SGTC_521 r062-0005 13.8 µM -0.00211580169186778 0.485505777402094 no 1619 0.499155917877941 2408 2832033
SGTC_98 0074-0023 107.663 µM -0.00304624492169332 0.485941751967649 no 1620 0.498784725983823 2419 3563821
SGTC_2917 7979103 53.79 µM -0.00394662379814205 0.486363655386697 no 1621 0.498425528989368 2412 2980565
SGTC_1640 st009078 66.4 µM -0.00427628599869611 0.486518133765444 no 1622 0.498294013911487 2413 690618
SGTC_2761 levamisole 97.89 µM -0.00534408186083875 0.487018512373545 no 1623 0.497868029943687 2419 26879 An alkaline phosphatase inhibitor.
SGTC_1157 4092-0394 27.6 µM -0.00767636790565753 0.488111512282319 no 1624 0.496937602358672 2424 3659885
SGTC_896 0964-0007 44.5 µM -0.00798803388554387 0.488257578019841 no 1625 0.496813269435995 2405 6756758
SGTC_425 3825-7017 13.1 µM -0.00853364425572735 0.488513288185431 no 1626 0.496595609820235 2465 3397440
SGTC_26 0302-0163 425.158 µM -0.00874463555197541 0.488612174343339 no 1627 0.49651143961259 2423 3100915
SGTC_2740 felodipine 17.08 µM -0.00985152272266425 0.48913095503128 no 1628 0.496069874631112 2425 3333 L-type calcium channel blocker
SGTC_3193 9111931 49.47 µM -0.0100561267825484 0.489226851790838 no 1629 0.495988253464581 2438 17087244
SGTC_3068 9116768 49.47 µM -0.0105468413872278 0.489456849463529 no 1630 0.495792497050296 2437 41904888
SGTC_154 3389-1638 511.116 µM -0.0112626543829832 0.489792356897898 no 1631 0.495506945965972 2451 5238686
SGTC_610 4215-0184 155 µM -0.0114088122017405 0.489860863164519 no 1632 0.49544864117868 2432 5605015
SGTC_636 0kpi-0074 126 µM -0.0120401218139363 0.490156770447884 no 1633 0.495196802396401 2447 616434
SGTC_2846 9008642 19.48 µM -0.0121671059266021 0.490216291069079 no 1634 0.495146146775549 2452 2992898
SGTC_977 1348-1378 135 µM -0.0126371626335742 0.490436620258624 no 1635 0.494958635704047 2430 X977
SGTC_1145 3546-0597 10.2 µM -0.012895504355289 0.490557713751072 no 1636 0.494855580667009 2452 875334
SGTC_1634 st006576 41 µM -0.0129179161215354 0.490568218944227 no 1637 0.494846640410554 2439 3915356
SGTC_1999 st074831 12.5 µM -0.0131576896889355 0.490680609764032 no 1638 0.494750992726673 2442 17112523
SGTC_2646 retinol 96.75 µM -0.0131885649474273 0.490695082203968 no 1639 0.494738676349327 2436 445354 A vitamin A analog and teratogen.
SGTC_539 4859-0462 2.54 µM -0.0136635449456172 0.490917725418613 no 1640 0.494549203825314 2428 46499474 YNL221C | YBR257W POP1 | POP4
SGTC_1329 1447-1697 50.6 µM -0.0139263779525934 0.491040927586232 no 1641 0.494444358602996 2475 2840515
SGTC_1146 3579-1023 7 µM -0.0142382111245045 0.491187099538856 no 1642 0.494319967501467 2444 X1146
SGTC_15 0266-0086 27.098 µM -0.0152614990416209 0.491666774462298 no 1643 0.493911779108899 2425 1712902 YIL048W NEO1
SGTC_3173 9105693 49.47 µM -0.0159884424459122 0.492007542734351 no 1644 0.493621806054982 2448 17096658
SGTC_3104 9120930 49.47 µM -0.01670414197448 0.492343045929808 no 1645 0.493336321402543 2466 17014836
SGTC_2700 st077718 96.8 µM -0.0170462080331226 0.492503400423329 no 1646 0.493199876218961 2442 904970
SGTC_1790 st045711 43.5 µM -0.0173332766538405 0.492637974030682 no 1647 0.493085369328086 2445 585119
SGTC_1860 st056228 74.6 µM -0.017368655070419 0.492654558977748 no 1648 0.493071257506284 2490 688679
SGTC_1877 wortmannin 25 µM -0.0186610347171771 0.493260418420039 no 1649 0.492555756314515 2434 312145 A covalent inhibitor of PI 3-kinase.
SGTC_3086 9117350 49.47 µM -0.0188343599991689 0.493341673434106 no 1650 0.492486621682007 2448 2679265
SGTC_2042 p-Dimethylaminoacetophenone 200 µM -0.0191470691053159 0.493488272379501 no 1651 0.49236189129247 2463 75037 A free radical scavenger.
SGTC_2573 2',4'-dihydroxychalcone 15.04 µM -0.0192069893975211 0.493516363289105 no 1652 0.49233799094964 2456 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_1028 k015-0029 4.8 µM -0.0192823803344816 0.493551706954049 no 1653 0.492307919886378 2433 4588309
SGTC_588 3970-1144 52.9 µM -0.0192908512268097 0.493555678155776 no 1654 0.49230454111774 2463 1888707
SGTC_227 fluconazole 33.516 µM -0.0206333354236564 0.494185050070097 no 1655 0.491769074149501 2444 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C
SGTC_43 0570-0105 72.5 µM -0.0214002615326865 0.494544600380504 no 1656 0.491463182470688 2445 1114046 YDL195W SEC31
SGTC_315 k915-0449 187 µM -0.0215426233970528 0.494611342968393 no 1657 0.491406401394119 2463 20970215 YNL149C PGA2
SGTC_615 k087-0205 167 µM -0.0237439496386073 0.495643394500383 no 1658 0.490528424566933 2451 9642773
SGTC_2878 9043973 25.97 µM -0.0238198287023596 0.495678969570623 no 1659 0.490498161759415 2531 6465167
SGTC_1783 st039459 87.517 µM -0.0240514163980456 0.495787547143487 no 1660 0.4904057980982 2473 729761
SGTC_1282 0886-0010 32.4 µM -0.0243269635987052 0.495916735096074 no 1661 0.490295902825453 2460 2836211 YNL267W PIK1
SGTC_1820 st053765 18.6 µM -0.0244419342564811 0.495970638234816 no 1662 0.490250049803247 2470 3690829
SGTC_142 0335-0849 62.6745 µM -0.0246559051584316 0.496070957097639 no 1663 0.490164713481665 2450 3889043 YPR107C YTH1
SGTC_170 4197-0004 226 µM -0.0248591353759269 0.496166240490724 no 1664 0.49008366119908 2475 218692
SGTC_800 3448-7362 155 µM -0.0261045289356612 0.496750141128527 no 1665 0.489586982363316 2443 15991913
SGTC_48 0382-0018 55 µM -0.0263661885798675 0.496872820731552 no 1666 0.489482631186792 2449 762596
SGTC_472 calcifediol 10 µM -0.0277783630968725 0.497534926149599 no 1667 0.488919461525058 2495 5283731 A vitamin D metabolite.
SGTC_68 0986-0284 82.829 µM -0.0281492017684258 0.49770879700288 no 1668 0.488771576133121 2603 423278 YIL048W NEO1
SGTC_1749 st037932 54.2 µM -0.0288652390134914 0.498044518334696 no 1669 0.488486034655694 2505 594497
SGTC_927 2425-1185 123 µM -0.029034479751954 0.4981238687843 no 1670 0.488418545656637 2459 730375
SGTC_1527 coumarin 137 µM -0.0295620529631193 0.498371227960901 no 1671 0.488208164712796 2578 323 A hepatotoxic, DNA x-linker.
SGTC_3182 9108849 49.47 µM -0.0296037449334152 0.498390775780931 no 1672 0.488191539299533 2498 17133045
SGTC_1456 k015-0012 13 µM -0.0298671000748414 0.49851425333583 no 1673 0.488086522237224 2457 2989616
SGTC_928 2764-0428 58.7 µM -0.0299541373474614 0.498555061948656 no 1674 0.488051814918055 2551 662578
SGTC_1482 3346-2049 8.48 µM -0.0304102782537529 0.498768930073652 no 1675 0.487869923893402 2513 3826804
SGTC_961 1252-1571 372 µM -0.031332708268934 0.499201425469342 no 1676 0.487502102890174 2465 6813498
SGTC_540 1187-0821 17.3 µM -0.0316640090467367 0.499356761152688 no 1677 0.487369998552675 2460 847520
SGTC_2349 9023730 187.07 µM -0.0328628432650256 0.499918854446955 no 1678 0.486891981779853 2482 4126287
SGTC_2282 7944268 200 µM -0.0332089780407924 0.499918854446955 no 1679 0.486753969315751 2492 2970414
SGTC_1024 4507-0395 26 µM -0.0347277986131426 0.499206730416521 no 1680 0.486148397102244 2597 4201836
SGTC_160 3453-0671 289.699 µM -0.0363098950666864 0.498464941168722 no 1681 0.485517630010761 2480 5322268
SGTC_1940 st075990 51.1 µM -0.0369046124018596 0.498186100412445 no 1682 0.485280531044699 2660 1084979
SGTC_362 0310-0100 9.03 µM -0.038547536868035 0.497415799485783 no 1683 0.48462556534329 2507 790235
SGTC_2651 TUB2.036 5 µM -0.0393296895979504 0.497049082869823 no 1684 0.48431376802314 2511 15992207 YFL037W TUB2
SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM -0.0403828323387037 0.496555315090092 no 1685 0.483893958446671 2457 368090
SGTC_2082 5219693 150 µM -0.0407226573612927 0.496395988635259 no 1686 0.483758499306658 2470 2834649
SGTC_2544 sphondin 68.51 µM -0.0417500978420078 0.495914278299528 no 1687 0.483348958224149 2483 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31
SGTC_683 panaxydol 45 µM -0.0418837425861142 0.49585162005189 no 1688 0.48329568828095 2535 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis.
SGTC_2541 muurolladie-3-one 83.07 µM -0.0424052479891945 0.495607117492654 no 1689 0.483087822411915 2615 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils. YMR203W TOM40
SGTC_584 0986-0246 15.4 µM -0.0425791207859672 0.4955255993442 no 1690 0.483018519796115 2467 53315 YDR232W HEM1
SGTC_1372 2752-0194 270 µM -0.0430742053007294 0.495293486018918 no 1691 0.482821190698745 2489 823334
SGTC_2409 alverine citrate 63.97 µM -0.0437419670973205 0.494980417947155 no 1692 0.482555043153789 2745 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_601 0986-0029 62.9 µM -0.0437888803522079 0.494958423627904 no 1693 0.482536345388447 2497 24747981
SGTC_2671 danthron 100 µM -0.0438526611295005 0.494928521340643 no 1694 0.48251092495835 2502 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin.
SGTC_127 0180-0333 59.125 µM -0.0443164699687551 0.494711075106858 no 1695 0.48232607171772 2471 771601
SGTC_3124 9127567 49.47 µM -0.0446089239743886 0.494573965496356 no 1696 0.482209514719772 2488 17592030
SGTC_3197 9113331 49.47 µM -0.0448779515072127 0.494447839356504 no 1697 0.482102295641362 2520 16610459 YLR208W | YDL195W SEC13 | SEC31
SGTC_2944 9067346 25.62 µM -0.0450650817537998 0.494360108827384 no 1698 0.482027716927695 2509 6473075
SGTC_888 0916-0002 6.97 µM -0.0458733918735626 0.493981159516649 no 1699 0.481705581026356 2632 2802138 YIL048W NEO1
SGTC_1380 2291-0730 164 µM -0.0461348386612594 0.493858590033428 no 1700 0.481601389162038 2529 2999191
SGTC_1866 st057638 64 µM -0.0469510080442702 0.493475963528901 no 1701 0.481276137174594 2521 688802
SGTC_618 k072-0232 33.2 µM -0.047038647846926 0.493434877663804 no 1702 0.481241212538952 2519 5872756 YGL099W LSG1
SGTC_1710 st031758 61.5 µM -0.0479900034190789 0.49298888321043 no 1703 0.480862104772385 2600 5394341
SGTC_2636 apigenin dimethyl ether 100 µM -0.0483486070449774 0.492820772466536 no 1704 0.480719208500895 2564 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_1565 sinapyl alcohol 95.1 µM -0.0487945982121864 0.492611696868032 no 1705 0.480541493525408 2522 5280507 A phenol propionate derived from cinnamic acid.
SGTC_2466 5983409 37.09 µM -0.0489818446906052 0.492523918445291 no 1706 0.480466882204416 2546 2879657
SGTC_3187 9109394 49.47 µM -0.0493963913386311 0.492329586306617 no 1707 0.480301701973937 2527 17098090
SGTC_251 melphalan 456.522 µM -0.0505714578638725 0.491778745944006 no 1708 0.479833503518904 2529 460612 A DNA alkylator.
SGTC_122 0236-0016 402.397 µM -0.0507263184214016 0.491706152523497 no 1709 0.479771802287168 2490 6808838
SGTC_1140 3229-1848 2.98 µM -0.0507540160438156 0.491693168838631 no 1710 0.47976076674952 2493 2849525
SGTC_2869 9037858 32.47 µM -0.0507569885142618 0.49169177544809 no 1711 0.479759582431837 2489 27187042
SGTC_862 0452-0056 10.2 µM -0.0512668186905677 0.491452786345638 no 1712 0.479556454084638 2500 1575396 YLR359W | YHR072W ADE13 | ERG7
SGTC_2751 anetholtrithion 17.25 µM -0.0512889884766177 0.491442394057496 no 1713 0.479547621239917 2538 2194 A chloretic substance that stimulates the liver to produce bile.
SGTC_27 0485-0001 32.618 µM -0.0521574339690384 0.49103530700307 no 1714 0.479201624755874 2480 2054479
SGTC_3049 9092223 49.47 µM -0.0528025824332881 0.490732897282325 no 1715 0.478944601944463 2570 8623917
SGTC_3052 9092717 49.47 µM -0.053316953047897 0.490491792752528 no 1716 0.478739686417207 2575 25237534
SGTC_1967 st070177 51.4 µM -0.0537279132896039 0.490299162981322 no 1717 0.478575971663197 2546 5729214
SGTC_264 promethazine 12.5 mM -0.0539558844979043 0.490192306800466 no 1718 0.478485156040114 2488 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3
SGTC_1951 sophoraflavanone G 9.2 µM -0.0541387234265413 0.490106605830188 no 1719 0.478412320319418 2494 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity.
SGTC_979 1426-2828 121 µM -0.0557143496539068 0.489368091550285 no 1720 0.47778468394423 2581 747872
SGTC_1961 st076550 68.7 µM -0.0558204717766891 0.489318352162883 no 1721 0.477742413124929 2569 1579337
SGTC_780 0109-0199 192 µM -0.0573378144915745 0.488607192912351 no 1722 0.477138049139391 2512 610414
SGTC_918 glabranin 770.725 nM -0.0576572312504424 0.488457490875327 no 1723 0.477010830753422 2542 124049 Also referred to as licorice root.
SGTC_2659 sanguinarine 24.21 µM -0.0578248743596199 0.488378921711953 no 1724 0.476944062226165 2504 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis.
SGTC_2432 5630864 12.22 µM -0.0580148316733616 0.488289895113177 no 1725 0.476868407229107 2589 5714970
SGTC_2067 5224629 34.075 µM -0.0581091240860511 0.488245703649762 no 1726 0.476830853353045 2565 2835000
SGTC_1454 4239-0054 42.6 µM -0.0581715752217132 0.488216435127402 no 1727 0.476805981028083 2660 1340767
SGTC_360 0957-0399 1.01 µM -0.058506433090681 0.488059500796578 no 1728 0.476672619204499 2566 6752301 YPR165W RHO1
SGTC_2301 7769476 200 µM -0.0588200767721579 0.487912510373216 no 1729 0.476547708596786 2544 977820
SGTC_1939 st074455 53.6 µM -0.0588322798903732 0.487906791363872 no 1730 0.476542848673186 2513 1644229
SGTC_1792 st045773 43.6 µM -0.0597349526912832 0.487483759399295 no 1731 0.476183366603429 2515 2919270
SGTC_3032 9089427 49.47 µM -0.0600650826419381 0.48732904955369 no 1732 0.47605189987248 2579 17173707
SGTC_1408 3909-7976 48.8 µM -0.061182748604785 0.48680528850248 no 1733 0.475606834305233 2539 24152374
SGTC_693 4161-2696 114 µM -0.0628009648322978 0.486046999963107 no 1734 0.47496249878125 2589 805759
SGTC_2332 7982454 138.89 µM -0.063018243459177 0.485945187998348 no 1735 0.474875988507337 2495 2981748
SGTC_1564 D-Arginine 115 µM -0.0639348446851472 0.485515699074558 no 1736 0.474511053489029 2547 71070 D-isomer of arginine; arginine decarboxylase inhibitor.
SGTC_3145 9085516 49.47 µM -0.0640804805648636 0.485447460467175 no 1737 0.474453072075227 2592 25236195
SGTC_3208 9114115 49.47 µM -0.0643926611075023 0.485301187748894 no 1738 0.474328786744437 2587 650895
SGTC_1254 0550-0035 264 µM -0.0644070680173726 0.485294437414636 no 1739 0.47432305112509 2587 15121435
SGTC_2790 5423970 71.43 µM -0.0645454828326402 0.485229583592409 no 1740 0.474267946262907 2586 1376240 YKL165C | YIL048W MCD4 | NEO1
SGTC_3344 9148862 3.898 µM -0.0646061317174153 0.485201166873006 no 1741 0.4742438012538 2573 4905352
SGTC_893 0958-0369 48.9 µM -0.0648204362225714 0.485100756215087 no 1742 0.47415848495732 2664 6819948
SGTC_2977 9011197 71.43 µM -0.0649121605624172 0.485057779799296 no 1743 0.474121969143532 2696 2704722
SGTC_106 0092-0003 11.579 µM -0.0649940719876242 0.485019401261838 no 1744 0.474089360072705 2624 1072148
SGTC_1781 st038725 66.3 µM -0.0654373242271972 0.484811723581777 no 1745 0.473912903656435 2528 4270275 YIL048W NEO1
SGTC_475 α-linolenic acid 10 µM -0.0654861139533168 0.484788864304116 no 1746 0.473893481031725 2667 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_2523 spermine 47.74 µM -0.0659354493720652 0.484578341130917 no 1747 0.47371460873074 2545 1103 A DNA binding polyamine.
SGTC_1647 st011722 22.4 µM -0.0683209088645395 0.483460776165245 no 1748 0.472765090074421 2570 2854783
SGTC_2890 9046729 58.44 µM -0.0690370229832743 0.483125308503838 no 1749 0.472480074854146 2561 903329
SGTC_1111 tnp00062 510.699 nM -0.0708894372965704 0.482257590664901 no 1750 0.47174287502119 2644 676306
SGTC_1808 st050063 61.5 µM -0.0729928407985024 0.481272405240411 no 1751 0.470905907265035 2521 4011993
SGTC_700 3453-2283 142 µM -0.0744690775780795 0.480581038106519 no 1752 0.470318572672723 2616 565664
SGTC_1854 st056233 32.9 µM -0.0751801782575219 0.480248028481003 no 1753 0.470035677587379 2536 5393174
SGTC_3174 9107204 49.47 µM -0.0756108471648627 0.480046352206163 no 1754 0.46986435319071 2602 3938802
SGTC_902 1120-0002 2.07 µM -0.0759062040355773 0.479908043630456 no 1755 0.469746860497933 2561 3280475
SGTC_2912 7964298 10.93 µM -0.0759530305178374 0.479886116127762 no 1756 0.469728233207807 2598 2975850
SGTC_2124 5246320 200 µM -0.0763989430055599 0.479677311119127 no 1757 0.469550855254578 2625 579342
SGTC_2597 laccaic acid a 100 µM -0.0765108112035933 0.47962492808095 no 1758 0.469506356546037 2605 5491415 A textile dye.
SGTC_1717 st033143 58.0435 µM -0.0769459959185668 0.479421153258655 no 1759 0.469333253266472 2589 674616
SGTC_1305 1181-0477 144 µM -0.0771973809284692 0.479303444918057 no 1760 0.469233262573688 2617 6252086
SGTC_733 4069-0007 56.1 µM -0.0772761631339949 0.479266556364419 no 1761 0.469201926628092 2543 5717425 YNL287W SEC21
SGTC_115 0527-0192 112.043 µM -0.0775052621119841 0.479159285308826 no 1762 0.469110802654011 2585 4233931
SGTC_2642 cholecalciferol 100 µM -0.0778947664435303 0.478976911094792 no 1763 0.468955881268123 2554 9821465 A vitamin D precursor, similar to steriods.
SGTC_2165 5727197 32.143 µM -0.077944136971736 0.47895379507673 no 1764 0.468936244977878 2898 1361712
SGTC_1151 3909-8316 15.3 µM -0.07820888037828 0.47882983947257 no 1765 0.468830949068297 2641 800431
SGTC_2618 avocadyne 43.43 µM -0.079556674815855 0.478198820161191 no 1766 0.468294927215309 2569 3015189
SGTC_2468 5987765 72.9 µM -0.0808276343903087 0.477603823940199 no 1767 0.467789515450104 2619 26772094
SGTC_1306 1185-0270 9.02 µM -0.0814693445872487 0.477303427962247 no 1768 0.467534351646445 2573 1548076
SGTC_2300 7976697 71.57 µM -0.0817455247303952 0.477174147075361 no 1769 0.467424537987219 2580 2236109
SGTC_2644 guaiazulene 100 µM -0.0818717268112025 0.477115072240643 no 1770 0.467374358838379 2606 3515 A coloring agent.
SGTC_2612 dictamnine 15.46 µM -0.082579872959088 0.476783600409969 no 1771 0.467092802827443 2636 68085 A quinoline derivative and established mutagen. YOR116C RPO31
SGTC_2253 7938677 135.83 µM -0.0828374877941653 0.476663019018633 no 1772 0.466990380299966 2710 2301972
SGTC_1969 st069479 40.1 µM -0.0838596579152548 0.47618459454312 no 1773 0.466584007425894 2619 3895485
SGTC_1206 3978-0017 132 µM -0.0845966464212958 0.475839669954023 no 1774 0.466291032640106 2805 3873677
SGTC_64 000l-0018 272.079 µM -0.0846751326185878 0.475802937988258 no 1775 0.466259833122658 2573 6811119
SGTC_1765 st044815 90.4 µM -0.0853878986649561 0.47546936906669 no 1776 0.465976506746065 2627 645695
SGTC_1367 1812-0510 76.9 µM -0.0855307576836702 0.475402514226717 no 1777 0.46591972198047 2601 1142582 YDR527W RBA50
SGTC_2754 granisetron 64.02 µM -0.0857469055875815 0.47530136313744 no 1778 0.465833807071676 2618 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients.
SGTC_22 0964-0034 14.468 µM -0.0862100006502898 0.475084653148099 no 1779 0.465649740469077 2585 138402
SGTC_187 1488-2104 32.728 µM -0.0886442467556116 0.473945645910468 no 1780 0.464682321323728 2634 2852859
SGTC_2638 epoxomicin 18 µM -0.0888706171295076 0.473839735708053 no 1781 0.46459236763176 2657 9915668 A protesome inhibitor.
SGTC_1843 st055809 45.5 µM -0.0896741809949688 0.473463793315143 no 1782 0.464273066921039 2675 16413835
SGTC_2918 7977171 22.06 µM -0.090714025878587 0.472977343433465 no 1783 0.463859912772389 2559 2236483
SGTC_23 0213-0011 39.996 µM -0.0908131034062411 0.472930996062142 no 1784 0.463820549031707 2634 627608
SGTC_2060 5238662 140 µM -0.0922786712203472 0.472245462791545 no 1785 0.463238316977934 2657 790130
SGTC_779 1360-0071 233 µM -0.0940441889368158 0.471419734456836 no 1786 0.462537027282333 2741 7566
SGTC_1062 mesoridazine 14.2 µM -0.0943622254933631 0.471271002488692 no 1787 0.46241071078079 2559 4078 A neuroleptic.
SGTC_1510 1123-0200 71.5 µM -0.0966138169439855 0.470218146162367 no 1788 0.461516541747163 2743 5378812 YNL149C | YNL150W PGA2 | YNL150W
SGTC_2537 larixol 68.93 µM -0.0967724209985124 0.470143989811971 no 1789 0.461453562985098 2551 6708759
SGTC_168 3970-0862 530.542 µM -0.0974670721034555 0.469819213432596 no 1790 0.461177741176405 2627 3135186
SGTC_292 k038-0015 474 µM -0.0984762617983676 0.469347413872812 no 1791 0.460777060333842 2674 46368540
SGTC_1168 k815-0004 80.5 µM -0.0989356258492544 0.469132673855004 no 1792 0.460594691159819 2578 642433
SGTC_1462 k081-0014 26.5 µM -0.09917666244759 0.469019999484428 no 1793 0.460499002079679 2562 3270634
SGTC_3311 9131146 2.8755 µM -0.0995234570570822 0.46885789209142 no 1794 0.460361332158317 2637 4900406 YPR165W RHO1
SGTC_828 2074-0507 139 µM -0.0997573399222618 0.468748567637837 no 1795 0.46026848842677 2683 X828
SGTC_1053 3366-3204 134 µM -0.100723395646773 0.46829702684951 no 1796 0.459885019389232 2617 3632071 YPR165W RHO1
SGTC_1337 1486-1011 40.3 µM -0.100962420170528 0.468185311488869 no 1797 0.459790146026836 2584 X1337
SGTC_1087 pterostilbene 9.05 µM -0.101031657517894 0.468152951782229 no 1798 0.459762664839202 2680 5281727 Similar to reservatol, lowers cholesterol.
SGTC_3036 9090181 49.47 µM -0.102216500771981 0.467599220142807 no 1799 0.459292415317079 2577 25236586
SGTC_2312 7706453 155.7 µM -0.102216627919568 0.467599160724248 no 1800 0.45929236485683 2612 976098
SGTC_1975 st070967 30.8 µM -0.102912607886768 0.467273926501718 no 1801 0.459016165593568 2618 261391
SGTC_3198 9112019 49.47 µM -0.103849232794206 0.466836272458996 no 1802 0.458644497768072 2599 45595555
SGTC_2782 7736369 71.43 µM -0.104398524296103 0.466579625206723 no 1803 0.458426546862689 2629 2950836 YOL077C BRX1
SGTC_541 4513-1321 94 µM -0.104673965555303 0.466450935117028 no 1804 0.458317260464682 2600 747515
SGTC_1586 deoxycorticosterone acetate 53.7 µM -0.104678713918518 0.466448716644641 no 1805 0.458315376491632 2596 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE.
SGTC_2736 butenafine 14.65 µM -0.105368617797375 0.466126399276825 no 1806 0.458041658391849 2623 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_3065 9113888 49.47 µM -0.105615759236341 0.466010942240894 no 1807 0.457943610312546 2721 16648368
SGTC_2198 6589944 200 µM -0.105878227639188 0.465888328041531 no 1808 0.457839484390532 2627 5290268
SGTC_774 k060-0086 136 µM -0.105942448007311 0.465858327479028 no 1809 0.457814007459236 2590 5911235
SGTC_1740 st038286 13.222 µM -0.106049713093148 0.465808218997646 no 1810 0.457771454598284 2725 716786
SGTC_634 1611-4317 11.2 µM -0.106202229931628 0.465736972263739 no 1811 0.457710950862529 2584 2843522
SGTC_263 alizarin 107.927 µM -0.106309703142878 0.465686767874602 no 1812 0.457668316612568 2574 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium.
SGTC_149 3970-0822 46.1 µM -0.107062395603342 0.465335174997962 no 1813 0.457369739804789 2580 3114250 YBL034C STU1
SGTC_1031 k035-0009 16 µM -0.107115907621596 0.46531017983408 no 1814 0.457348513659452 2768 5180959
SGTC_3140 9094243 49.47 µM -0.107288693612679 0.465229473400737 no 1815 0.457279976979075 2585 19291112
SGTC_653 0203-0016 55.2 µM -0.110138689585738 0.463898480484506 no 1816 0.456149692468497 2678 295302
SGTC_71 0417-1750 47.813 µM -0.1108554095286 0.463563823986932 no 1817 0.455865502813309 2633 6811472
SGTC_1002 4049-0206 172 µM -0.111714917823136 0.463162529649713 no 1818 0.455524725331672 2624 4662749
SGTC_1180 1193-0155 285 µM -0.111924549227176 0.463064660877263 no 1819 0.455441615715915 2698 2921347
SGTC_2894 9048625 32.47 µM -0.111938137723094 0.463058317012608 no 1820 0.455436228543223 2665 4092861
SGTC_1660 st012960 28.1 µM -0.112629745045515 0.462735448742707 no 1821 0.455162050977446 2667 24207266
SGTC_333 3486-0131 40.1 µM -0.112994469124201 0.46256519171944 no 1822 0.455017470065591 2746 6744690
SGTC_542 3381-0244 89.3 µM -0.113223873326713 0.462458106944337 no 1823 0.454926534594469 2761 1112843
SGTC_856 0433-0016 11.3 µM -0.113247995531228 0.462446846973595 no 1824 0.454916972727058 2676 3911780
SGTC_830 4076-0286 57.8 µM -0.114207906250676 0.461998796086106 no 1825 0.454536492319354 2634 6866659
SGTC_1607 st000305 50.6 µM -0.114580785882653 0.461824762611626 no 1826 0.454388705017127 2748 5457690
SGTC_2298 7976326 193.81 µM -0.114614827078276 0.461808874986064 no 1827 0.454375213426629 2656 2235818
SGTC_2654 protoveratrine a 100 µM -0.117514603606564 0.460455724507693 no 1828 0.453226136110088 2619 5702278 A heart drug and vasodilator.
SGTC_1861 st057647 17.4 µM -0.117716375406964 0.460361586656555 no 1829 0.453146195648995 2812 688668
SGTC_2303 7774051 200 µM -0.117735655878901 0.460352591352226 no 1830 0.453138556971188 2717 2953184
SGTC_3138 9097216 49.47 µM -0.118256345780267 0.460109671162983 no 1831 0.452932272819966 2578 25237486
SGTC_3241 9133421 49.47 µM -0.118801071275147 0.459855553459088 no 1832 0.452716479970798 2594 17018221
SGTC_1057 3448-5381 134 µM -0.118998495310918 0.459763458007784 no 1833 0.452638273939801 2731 5497911
SGTC_2885 9057732 51.95 µM -0.12041893421783 0.459100907787412 no 1834 0.452075646601338 2736 6471414
SGTC_2743 auranofin 4.32 µM -0.120569789763541 0.459030549292679 no 1835 0.452015899256723 2663 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold.
SGTC_809 3998-0021 90 µM -0.120583795558982 0.459024017104127 no 1836 0.452010352223173 2601 715485
SGTC_1983 st071813 46.9 µM -0.121728756463956 0.458490054273242 no 1837 0.451556919112624 2680 11838595
SGTC_726 3448-4391 34.2 µM -0.121738081532312 0.458485705749786 no 1838 0.451553226411323 2757 1356692
SGTC_191 3914-0123 66.505 µM -0.123524895129157 0.457652560089528 no 1839 0.450845730893789 2627 3144412
SGTC_2920 7982904 15.77 µM -0.123536733213676 0.45764704090868 no 1840 0.450841044078206 2720 6456808
SGTC_1767 st044992 70.3 µM -0.12377161194859 0.457537536857836 no 1841 0.450748054665328 2660 9600693
SGTC_527 4476-4215 268 µM -0.125190756082652 0.456875979075508 no 1842 0.450186267624041 2633 4418754
SGTC_1531 st059297 52.4 µM -0.125960868131353 0.456517028360148 no 1843 0.449881450250427 2731 7566702
SGTC_685 1278-0033 54.9 µM -0.126612879819928 0.456213152174784 no 1844 0.449623401182881 2670 3590572
SGTC_1712 st032288 53.4 µM -0.126790165049485 0.456130531145386 no 1845 0.449553240033544 2656 2883011
SGTC_401 neomycin 50 µM -0.127335045114964 0.455876610137694 no 1846 0.449337612031778 2670 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis.
SGTC_969 1313-0238 134 µM -0.127383086734299 0.455854222997943 no 1847 0.44931860100808 2643 5212874
SGTC_3024 9090631 49.47 µM -0.127805085706672 0.45565757974625 no 1848 0.449151612630782 2629 25236383
SGTC_1772 st048439 82.2 µM -0.127849201411146 0.455637023318757 no 1849 0.449134156212219 2689 2927068 YDL195W SEC31
SGTC_2111 5486399 200 µM -0.128049766361707 0.455543568327614 no 1850 0.449054794656415 2617 689674
SGTC_2319 6033012 152.6 µM -0.12838614176452 0.455386836794602 no 1851 0.448921698832835 2669 847246
SGTC_2566 crystal violet carbinol 226 nM -0.128427268295689 0.455367674679443 no 1852 0.448905426427219 2798 68050 Cationic dye that binds acidic phospholipids including cardiolipin.
SGTC_273 hydroxyurea 18.1 mM -0.12925928497532 0.454980034891409 no 1853 0.448576243491546 2648 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12
SGTC_444 curcumin 90.4 µM -0.12958681806498 0.454827447696591 no 1854 0.448446666480229 2742 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties.
SGTC_876 0720-0963 56.8 µM -0.131205783879138 0.4540733216077 no 1855 0.447806260320374 2832 765861
SGTC_236 1509-0011 5.31 µM -0.132230768408874 0.453595961741576 no 1856 0.447400882561571 2703 3107280
SGTC_1271 0832-2808 169 µM -0.133098850644357 0.453191727435784 no 1857 0.447057602056628 2761 3663794
SGTC_572 0960-0087 17.7 µM -0.133633222701729 0.452942913904862 no 1858 0.446846305941634 2645 6796365
SGTC_172 1112-0046 2.638 µM -0.133821054585907 0.452855460282534 no 1859 0.44677203889607 2700 2802135 YIL048W NEO1
SGTC_1362 1611-0397 101 µM -0.134020818526189 0.452762453661593 no 1860 0.446693056070784 2660 27816
SGTC_2587 piperic acid 92.2 µM -0.134553344531528 0.452514531479057 no 1861 0.446482515856255 2709 5370536
SGTC_590 k048-0076 22.4 µM -0.134793537620872 0.452402713518342 no 1862 0.44638755771887 2742 6832814
SGTC_1585 2',4'-dihydroxychalcone 10.4 µM -0.135776827922748 0.451944998268046 no 1863 0.445998855018191 2672 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_75 0159-0059 199.013 µM -0.136472284365389 0.451621306334063 no 1864 0.445723966704917 2909 5377270
SGTC_79 0052-0007 94.094 µM -0.136979715180257 0.451385148975097 no 1865 0.445523414450565 2775 2801472
SGTC_2193 5925765 200 µM -0.13817646868316 0.450828250401651 no 1866 0.445050475979441 2756 877370
SGTC_259 usnic acid 108.925 µM -0.138339848478998 0.45075223055412 no 1867 0.444985916863336 2831 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_1477 0139-0234 16 µM -0.138473343257156 0.450690117405153 no 1868 0.444933167820056 2628 620880
SGTC_325 2810-4341 181 µM -0.139154310615657 0.450373292172333 no 1869 0.444664105996146 2765 774970
SGTC_2186 6124449 200 µM -0.139289844395267 0.450310237819409 no 1870 0.444610557325188 2777 3834182 YLR033W RSC58
SGTC_1153 4055-0057 267 µM -0.140081230603037 0.449942086467545 no 1871 0.444297905085459 2653 882706
SGTC_2318 6029776 164 µM -0.140948718793224 0.449538582119104 no 1872 0.443955227128506 2787 818325
SGTC_271 rotenone 740 µM -0.141013611438337 0.449508399979671 no 1873 0.443929594709621 2790 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria.
SGTC_1068 loratadine 26.9 µM -0.142088788619336 0.449008368271465 no 1874 0.443504936855746 2706 3957 A H1 histamine antagonist.
SGTC_3238 9133470 49.47 µM -0.142791050864784 0.448681811454341 no 1875 0.443227602515019 2779 3534688
SGTC_2719 novobiocin 32.65 µM -0.143180020226759 0.448500952948341 no 1876 0.44307400439081 2725 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication.
SGTC_1645 Cervolide 78 µM -0.143243186781128 0.448471583498609 no 1877 0.443049061679616 2724 23173 A fragrance.
SGTC_260 nsc-65238 3.989 µM -0.143435423911369 0.448382204095311 no 1878 0.442973153985548 2765 3246252
SGTC_3114 9122766 49.47 µM -0.144663363784847 0.447811343448372 no 1879 0.442488333138154 2710 17176985
SGTC_2340 7987427 183.45 µM -0.145007137837577 0.447651544611992 no 1880 0.442352618089777 2768 2239331
SGTC_2836 9010338 19.48 µM -0.145251187337103 0.447538106574645 no 1881 0.442256276384748 2686 2994051
SGTC_1678 st019265 80.2 µM -0.146389277903927 0.447009161029875 no 1882 0.441807045561064 2796 5367020
SGTC_1544 7-methoxy-4-methylcoumarin 105 µM -0.146455930267877 0.446978186204604 no 1883 0.441780738636623 2699 390807
SGTC_2047 4141938 200 µM -0.146813052204772 0.446812229268679 no 1884 0.441639791076388 2674 3807862
SGTC_994 3910-0338 138 µM -0.147013339498607 0.446719158507773 no 1885 0.441560745664085 2804 3479481
SGTC_1377 2944-0135 198 µM -0.14701433662922 0.446718695162178 no 1886 0.441560352142193 2755 1894137
SGTC_2189 6047310 154.431 µM -0.147454327953673 0.446514247566825 no 1887 0.441386713304928 2645 711535
SGTC_1680 diphenhydramine 100 µM -0.148094949627871 0.446216599946345 no 1888 0.4411339175553 2742 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1
SGTC_867 0518-0118 155 µM -0.148622629631716 0.44597145038628 no 1889 0.440925707732048 2689 6848158
SGTC_1822 st052468 42 µM -0.148775814072425 0.445900287827287 no 1890 0.44086526789588 2705 2873678
SGTC_2880 9042983 58.44 µM -0.148898749659992 0.445843178776973 no 1891 0.440816763921632 2810 6464714
SGTC_1194 1488-0194 225 µM -0.149040925804228 0.445777133033182 no 1892 0.440760669733942 2642 1391452
SGTC_2472 5377652 49.4 µM -0.149646400432379 0.445495885965 no 1893 0.44052179904697 2719 1610903
SGTC_660 4031-1742 102 µM -0.149732421255986 0.445455930931319 no 1894 0.440487864030736 2651 6738706
SGTC_2125 5246583 200 µM -0.150688851392646 0.445011724769296 no 1895 0.440110584053311 2703 835267
SGTC_967 1306-0166 352 µM -0.152047140249942 0.444380997382823 no 1896 0.439574877653215 2737 4437607
SGTC_2699 st077704 54.6 µM -0.152348169919173 0.444241231943039 no 1897 0.439456167097093 2727 645852
SGTC_47 0149-0135 24.25 µM -0.153254828789514 0.443820320127397 no 1898 0.439098660592748 2642 5239155
SGTC_2780 5215298 71.43 µM -0.15400906072504 0.44347022001045 no 1899 0.438801295698774 2750 2834131
SGTC_3053 9095903 49.47 µM -0.154941773912135 0.443037333337555 no 1900 0.438433610237314 2681 17174018
SGTC_1065 prochlorperazine maleate 2.48 µM -0.155086652511027 0.442970099017243 no 1901 0.438376502311921 2686 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine.
SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM -0.155760054952163 0.44265761236635 no 1902 0.438111078889649 2698 689007
SGTC_2926 9010726 65.15 µM -0.156350789468059 0.442383516423145 no 1903 0.437878262175371 2789 2994293
SGTC_2955 9076254 12.21 µM -0.157474793735864 0.441862063979283 no 1904 0.437435335857531 2733 16459619
SGTC_340 k038-0059 454 µM -0.157575695392216 0.441815258203428 no 1905 0.437395578269846 2675 23733424
SGTC_752 1896-0090 130 µM -0.15770627784254 0.441754685449511 no 1906 0.437344126700906 2682 772567
SGTC_253 dyclonine 31.25 µM -0.157777040796764 0.441721861492645 no 1907 0.437316245410493 2669 3180 An oral anasthetic.
SGTC_2306 7482397 179.52 µM -0.158477950261334 0.441396760734887 no 1908 0.437040097115731 2811 891448
SGTC_1901 st060216 58.6 µM -0.159538358205444 0.440904989980718 no 1909 0.436622369914609 2682 688792
SGTC_1293 1000-1278 195 µM -0.160564465221368 0.440429213225246 no 1910 0.436218222167746 2808 678847
SGTC_1974 st069448 26.9 µM -0.16157289281597 0.43996171769225 no 1911 0.435821102595244 2809 6323587 YNR016C ACC1
SGTC_1471 k673-0312 37 µM -0.163556166859726 0.439042539223792 no 1912 0.435040276848348 2697 24099884
SGTC_2506 ethyl hematommate 54.16 µM -0.163842287004194 0.43890995950594 no 1913 0.434927650627795 2763 3940691 An allergen.
SGTC_395 anisomycin 6.25 µM -0.16427181886642 0.438710939858938 no 1914 0.434758582792927 2753 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_3263 9137018 49.47 µM -0.165495946654698 0.438143836655883 no 1915 0.434276819972823 2721 43844957
SGTC_3088 9117578 49.47 µM -0.166257522564663 0.437791084447803 no 1916 0.433977146412515 2706 678341
SGTC_2308 7584454 197.62 µM -0.166644168752403 0.437612013786675 no 1917 0.433825018978692 2816 893577
SGTC_1063 disulfiram 1.84 µM -0.167019417728165 0.437438233828452 no 1918 0.433677385194154 2677 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_2439 5492030 7.2 µM -0.168252858872996 0.436867105346292 no 1919 0.43319217912351 2805 5722370
SGTC_703 3875-0075 71.8 µM -0.168441030937165 0.436779986316951 no 1920 0.433118165594745 2726 2850814
SGTC_2454 5-benzylidenerhodanine 10.36 µM -0.169320776384735 0.436372726593374 no 1921 0.432772167365534 2881 1273210
SGTC_1217 1183-1422 255 µM -0.169366546917013 0.436351539926348 no 1922 0.432754167517545 2830 2849664
SGTC_2004 4023728 41.89 µM -0.171152511684751 0.435524979996834 no 1923 0.432051923309374 2793 360084 YDR527W RBA50
SGTC_923 1900-2434 73.3 µM -0.171847056156917 0.435203614661236 no 1924 0.431778885152474 2696 5910570
SGTC_3338 9144300 39.5675 µM -0.172290785242556 0.434998323853491 no 1925 0.431604464171005 2783 4901274
SGTC_166 k072-0058 166.424 µM -0.173097989290839 0.43462491669122 no 1926 0.431287202704619 2728 5846229
SGTC_3219 9131112 49.47 µM -0.173220522087197 0.434568238933265 no 1927 0.431239046589973 2748 17612988 YMR079W SEC14
SGTC_2888 9058547 12.99 µM -0.173242655969362 0.434558001010955 no 1928 0.431230347952168 2736 16476514
SGTC_2835 9006588 71.43 µM -0.173686616063909 0.434352658650095 no 1929 0.431055878241263 2954 2345538
SGTC_366 0181-0206 4.31 µM -0.173747189542677 0.4343246433121 no 1930 0.431032074807675 2814 274874
SGTC_951 1171-0579 82.7 µM -0.174052940883186 0.434183237828797 no 1931 0.430911928166616 2662 1616050 YPR165W | YDR526C RHO1 | YDR526C
SGTC_852 0418-0143 439 µM -0.174129072343845 0.434148029460433 no 1932 0.430882012891638 2789 5369229
SGTC_549 1661-1316 519 µM -0.174616851873519 0.433922459418492 no 1933 0.430690353074937 2786 2857282
SGTC_1492 4158-0558 28.5 µM -0.174955713897008 0.433765767839175 no 1934 0.430557215984305 2824 3967268
SGTC_747 3448-8087 38.7 µM -0.175310038331221 0.433601937491766 no 1935 0.430418012236166 2770 5168703
SGTC_1572 epiandrosterone 68.9 µM -0.17614625583991 0.433215337674168 no 1936 0.430089521050722 2714 441302 A steroid.
SGTC_3016 9080866 49.47 µM -0.176326182412025 0.433132162418765 no 1937 0.430018846842672 2732 17066299
SGTC_563 tetrahydrosecaminediol 614 µM -0.176435726846611 0.433081524398738 no 1938 0.429975819464792 2856 334274 A psychoactive constituent of the cannabis plant.
SGTC_908 3448-7491 47.7 µM -0.176807703965683 0.432909582427563 no 1939 0.429829718753022 2740 1203031
SGTC_300 r073-0011 5.04 µM -0.177902960956901 0.432403386866748 no 1940 0.429399592717632 2735 2735780
SGTC_1446 4239-0190 62 µM -0.178587541396487 0.432087050209986 no 1941 0.429130788871584 2736 1340085
SGTC_3181 9108277 49.47 µM -0.180857956814336 0.43103823037603 no 1942 0.428239535082749 2739 17097298
SGTC_1105 epirubicin 18.1 µM -0.180990004631274 0.430977245691683 no 1943 0.428187710799437 2729 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_435 c-PAF 6.7 µM -0.18124488689202 0.430859536063043 no 1944 0.428087681672238 2847 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase
SGTC_2811 7967822 32.47 µM -0.181742665942128 0.430629669651061 no 1945 0.427892340473737 2854 2232244
SGTC_793 0488-0545 106 µM -0.181830476975657 0.430589122355214 no 1946 0.427857883016242 2711 292548
SGTC_1266 0828-0227 32.9 µM -0.183938905230293 0.429615763066635 no 1947 0.42703069176403 2847 3913820
SGTC_1041 0206-0046 107 µM -0.184640395612739 0.429292013435885 no 1948 0.426755549772066 2822 50494
SGTC_517 1365-0151 113 µM -0.186611577468115 0.428382535044786 no 1949 0.4259825943521 2901 768657
SGTC_1541 2',3',6-trimethoxyflavone 64 µM -0.186971786012057 0.42821638032489 no 1950 0.425841377163796 2756 688801
SGTC_465 cgp-37157 41 µM -0.187146007620807 0.428136021046736 no 1951 0.425773078237059 2828 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange.
SGTC_2061 5245884 80.95 µM -0.187247220437043 0.428089338258549 no 1952 0.425733401479207 2721 573863
SGTC_1081 sertraline 6 µM -0.188178629944603 0.427659787889463 no 1953 0.425368312026636 2851 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1
SGTC_1659 st012954 42.1 µM -0.189185648601917 0.427195464318748 no 1954 0.424973657655777 2875 24207262
SGTC_2779 methotrexate 400 µM -0.190555429925957 0.426564037461423 no 1955 0.424436955997369 2766 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2
SGTC_2261 9010538 184.68 µM -0.191349730761136 0.426197975411338 no 1956 0.424125800657496 2875 6457250
SGTC_2757 clomiphene 4.22 µM -0.191686895115511 0.426042608809651 no 1957 0.423993735906515 2927 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined.
SGTC_2088 5278280 127.392 µM -0.192780435207209 0.42553878053735 no 1958 0.423565463254195 2832 791502
SGTC_760 0568-0725 82.9 µM -0.194313331843714 0.424832731704922 no 1959 0.422965273642094 2905 3916171
SGTC_3055 9094636 49.47 µM -0.195295115550367 0.424380650780873 no 1960 0.42258096033974 2914 25236176
SGTC_3341 9147222 25.867 µM -0.195342072697894 0.424359030959696 no 1961 0.422562581091389 2874 1939759
SGTC_2748 diazoxide 86.69 µM -0.195446117350358 0.424311127949821 no 1962 0.422521858125824 2830 3019 A potassium channel activatior.
SGTC_1116 jasmonic acid 1.58368 µM -0.196208226194231 0.423960280931405 no 1963 0.422223594815478 2909 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid.
SGTC_2283 7944793 200 µM -0.19627251434311 0.423930687772828 no 1964 0.422198436672273 2823 2970533
SGTC_2838 9002687 71.43 µM -0.196352807324579 0.423893727862739 no 1965 0.422167015738565 2726 6457060
SGTC_274 sirtinol 40.1 µM -0.196656128090966 0.423754111388582 no 1966 0.422048322143555 2783 6836442 NAD-dependent acetyltransferase inhibitor.
SGTC_899 1083-0020 478 µM -0.197367898024026 0.423426526166176 no 1967 0.421769824579872 2930 767123
SGTC_116 0155-0182 31.788 µM -0.19796851497372 0.423150139189485 no 1968 0.42153484879427 2762 771486
SGTC_178 4092-0806 87.505 µM -0.199353002179201 0.422513181505373 no 1969 0.42099331068408 2768 2169044
SGTC_1884 5633444 25 µM -0.199788156247728 0.422313022985341 no 1970 0.420823132266805 2908 5724239
SGTC_651 3253-0966 34.4 µM -0.200013720602394 0.422209277675829 no 1971 0.420734925226936 2793 781462
SGTC_9 0092-0002 10.449 µM -0.200020235219408 0.422206281444979 no 1972 0.420732377742199 2799 759368
SGTC_57 miconazole 162.5 nM -0.200122050586782 0.422159454665724 no 1973 0.420692564153265 2715 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM -0.20049717670903 0.421986936692256 no 1974 0.420545882914881 2779 6708561
SGTC_10 0279-0212 42.575 µM -0.202329661546102 0.421144405036618 no 1975 0.419829506456155 2791 39851 YBR002C RER2
SGTC_1873 rapamycin 2 nM -0.202463316196866 0.421082967979107 no 1976 0.419777266975845 2773 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1
SGTC_853 0419-0306 21 µM -0.203371942724544 0.42066535047127 no 1977 0.419422164006912 2767 762713
SGTC_1881 5652484 16 µM -0.203411450044082 0.420647194374397 no 1978 0.419406725523192 2898 2255129
SGTC_277 nystatin 15.5 µM -0.204560789512289 0.420119074679747 no 1979 0.418957646474885 2722 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_3034 9090421 49.47 µM -0.204770858329059 0.420022563900765 no 1980 0.418875578112199 2741 17173761
SGTC_184 1494-0393 24.714 µM -0.207260041704282 0.418879339524052 no 1981 0.41790338932543 2738 3090647
SGTC_1 0258-0098 57.368 µM -0.2072999980354 0.418860994062757 no 1982 0.417887787840476 2830 6790032 YDR047W HEM12
SGTC_1744 st037937 38.9 µM -0.207636879539689 0.41870632605451 no 1983 0.417756253082629 2952 1016152
SGTC_2775 cyproheptadine 69.59 µM -0.207679835957971 0.418686604937636 no 1984 0.417739481489948 2812 2913 A selective serotonin reuptake inhibitor.
SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM -0.208797084368685 0.418173752655956 no 1985 0.417303323755487 2819 4213774
SGTC_1551 6-bromo-3'-methylflavone 63.5 µM -0.208961311489397 0.418098378929075 no 1986 0.417239220409747 2938 688751
SGTC_174 3553-0389 74.3 µM -0.209862597612701 0.417684778011221 no 1987 0.41688745745659 2931 738071
SGTC_849 0386-0493 241 µM -0.210746096822172 0.417279427880248 no 1988 0.416542701128026 2788 726119
SGTC_2210 7115885 190.385 µM -0.210863250413346 0.417225684312068 no 1989 0.416496990630348 2785 2927039
SGTC_756 0508-1999 28.3 µM -0.210888716992446 0.417214001863006 no 1990 0.416487054336533 2799 6753853
SGTC_1958 st076513 41.9 µM -0.212395879302109 0.41652274202084 no 1991 0.415899100143501 2766 732122 YGL099W LSG1
SGTC_509 pifithrin 175 µM -0.212444641641178 0.41650038147746 no 1992 0.41588008076163 2799 4817 A p53 inhibitor.
SGTC_855 0428-0020 25 µM -0.212466400856749 0.416490403620743 no 1993 0.415871593807598 2796 6812414
SGTC_2455 5377712 9.75 µM -0.212816843766629 0.416329712728274 no 1994 0.415734912629936 2859 2243908
SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM -0.212974043273658 0.416257635545943 no 1995 0.415673604345786 2774 2724278 An inhibitor of dopamine biosynthesis.
SGTC_1047 2043-3044 82 µM -0.214395140315994 0.415606179711682 no 1996 0.415119465515548 2790 669592
SGTC_812 4251-0442 148 µM -0.215053349803974 0.415304523390811 no 1997 0.414862862180206 2789 5723007
SGTC_1000 4048-0884 8.67 µM -0.215422088378457 0.415135552914606 no 1998 0.414719125107554 2917 13040088
SGTC_573 3702-0553 84.7 µM -0.215554973923272 0.415074663392231 no 1999 0.41466732811934 2804 1222756
SGTC_389 tpck 16.7 µM -0.215633475416396 0.415038694159639 no 2000 0.41463672999604 2858 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.
SGTC_14 0354-0009 295 µM -0.216449190590855 0.414664977243372 no 2001 0.414318813182886 2753 1713507
SGTC_2329 6138490 200 µM -0.216896452379086 0.414460098653137 no 2002 0.414144521195321 3051 720019
SGTC_2064 5220758 200 µM -0.217354300684514 0.414250394767645 no 2003 0.413966121294841 2943 788518
SGTC_1450 4112-4260 37.6 µM -0.218894078736076 0.413545324599115 no 2004 0.413366279554516 2917 1633175
SGTC_2571 chrysanthemic acid 100 µM -0.219606145098622 0.413219360824405 no 2005 0.41308895257159 2854 2743 An insecticide.
SGTC_1457 k015-0032 57.3 µM -0.219717106992831 0.413168570998736 no 2006 0.413045740378698 2775 4302660
SGTC_1222 0366-0074 1.18 µM -0.220398940952514 0.412856511754312 no 2007 0.412780235066508 2939 286520
SGTC_269 exalamide 29 µM -0.2211176816499 0.412527620786101 no 2008 0.412500401511623 2820 3316 A derivative of salicylamide.
SGTC_237 nikkomycin 200 µM -0.221394762122464 0.41240084698959 no 2009 0.412392535234566 2949 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine.
SGTC_1070 indatraline 8.81 µM -0.221450374427471 0.41237540355804 no 2010 0.412370886392264 2825 10314472 A monamine transport inhibitor. YGL099W LSG1
SGTC_825 1988-2224 89.6 µM -0.221992704098131 0.412127299234115 no 2011 0.412159781464123 2792 1180859
SGTC_2497 7-hydroxyflavone 100 µM -0.223533053377161 0.411422813934093 no 2012 0.411560330487696 2983 5281894
SGTC_3286 9117135 37.221 µM -0.22533288214321 0.410600016403867 no 2013 0.410860160552954 2837 3438150
SGTC_2793 7325131 81.82 µM -0.22623629523433 0.410187166209401 no 2014 0.410508821398715 2880 4176441
SGTC_1953 st076800 12.1 µM -0.226757484969759 0.409949033272459 no 2015 0.41030616231304 2831 297591
SGTC_3048 9093155 49.47 µM -0.226901419868498 0.409883274893474 no 2016 0.410250198976538 2855 25236002
SGTC_2988 9073640 71.4286 µM -0.227035209719524 0.40982215367358 no 2017 0.410198181775602 2997 9102229
SGTC_2794 7785382 27.27 µM -0.227211469420507 0.409741633661758 no 2018 0.410129654802128 2807 2205081
SGTC_3172 9105863 49.47 µM -0.227731057181349 0.409504294631733 no 2019 0.409927663306054 2842 2348785
SGTC_661 1304-0007 33.6 µM -0.228965143562876 0.408940717609539 no 2020 0.409448003947433 2818 3117130
SGTC_2421 5690543 90.72 µM -0.228985824432021 0.408931274763333 no 2021 0.409439966949213 2893 3397993
SGTC_2046 4110841 106 µM -0.229362130656395 0.408759463280689 no 2022 0.409293733495361 2960 44119630 YMR134W ERG29
SGTC_1210 3013-0140 750 nM -0.229442323959734 0.408722851401637 no 2023 0.409262571826185 2967 905973
SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM -0.230112219016523 0.408417045081071 no 2024 0.409002285125016 2795 803109
SGTC_3163 9099914 49.47 µM -0.230372927808032 0.408298046881799 no 2025 0.408900997961482 2918 16268368
SGTC_2164 5685496 200 µM -0.230895564941101 0.40805951930835 no 2026 0.408697968158039 2838 759046
SGTC_1332 1480-0653 17.5 µM -0.231215764982837 0.40791339929293 no 2027 0.4085735915613 2917 5749438
SGTC_2113 5491891 107.031 µM -0.231509323604516 0.407779448069751 no 2028 0.408459571489374 2834 789979
SGTC_657 3534-0529 86.7 µM -0.232392555242778 0.407376493264927 no 2029 0.408116565360968 2981 1049549
SGTC_1242 0402-0103 60.1 µM -0.232922646409361 0.407134697979794 no 2030 0.40791073637058 2796 432868
SGTC_1622 st003707 19.4 µM -0.233146325775259 0.407032679695578 no 2031 0.407823891576172 2936 10140899
SGTC_290 2043-6722 48.1 µM -0.233491708741788 0.406875165809916 no 2032 0.407689803558921 2898 773758 YLR208W SEC13
SGTC_930 2810-3379 265 µM -0.235636230445724 0.40589748243627 no 2033 0.40685747856483 3026 1015764
SGTC_2132 5317594 122.667 µM -0.236838814047179 0.405349483171344 no 2034 0.406390919395462 2813 794577
SGTC_1687 st020778 55.3625 µM -0.238019488955114 0.404811647810434 no 2035 0.405932989264118 2861 4259299
SGTC_1776 st049249 45.9 µM -0.238154214225462 0.404750287528871 no 2036 0.405880743623087 2866 1822314
SGTC_1432 4049-0298 68.4 µM -0.238688627574795 0.404506913414423 no 2037 0.405673517895504 2933 741646
SGTC_1547 harmine 94.2 µM -0.238827271218162 0.404443780540645 no 2038 0.405619761335226 2852 5280953 A monoamine oxidase inhibitor YHR072W ERG7
SGTC_424 splitomicin 100 mM -0.240062392799074 0.403881464642505 no 2039 0.405140943997706 2913 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_3000 9075062 71.4286 µM -0.241632331148203 0.403167002902772 no 2040 0.404532533829257 2881 17057871
SGTC_388 3',4'-dichloroisocoumarin 16.7 µM -0.24188126647384 0.403053744783517 no 2041 0.404436083185311 2972 1609 A potent and irreversible inhibitor of serine proteases.
SGTC_3058 9093861 49.47 µM -0.242498185098157 0.402773100353339 no 2042 0.404197081489784 3015 17217477
SGTC_392 N-ethylmaleimide 8.33 µM -0.243457748073343 0.402336682075546 no 2043 0.403825406335649 2879 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides.
SGTC_1742 st038235 28.8875 µM -0.24374648026923 0.402205387748823 no 2044 0.403713586376622 2961 564103 YBR002C RER2
SGTC_2692 st077426 47.7 µM -0.244813249721206 0.401720394665041 no 2045 0.403300517127348 3007 25238571
SGTC_3023 9089636 49.47 µM -0.245281645982722 0.401507492062165 no 2046 0.403119181069558 2883 17249241
SGTC_3304 9125678 46.087 µM -0.245283867176941 0.401506482520734 no 2047 0.403118321200673 2868 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2
SGTC_1220 1838-0075 193 µM -0.245714025464645 0.401310986301346 no 2048 0.402951807124884 2856 5529645
SGTC_2913 7966556 36.57 µM -0.246101959324091 0.401134701215079 no 2049 0.402801653197531 2936 2976516
SGTC_2393 9031399 185.94 µM -0.246539122104385 0.400936069619425 no 2050 0.402632461872456 3004 1526623 YDL150W RPC53
SGTC_3017 9080681 49.47 µM -0.247585806818442 0.40046059655169 no 2051 0.402227446701289 2916 16451914
SGTC_594 1487-1584 10.8 µM -0.248565369032586 0.400015748507798 no 2052 0.401848499671507 2862 5013332
SGTC_1383 3049-0032 20.7 µM -0.248806528357608 0.399906250833515 no 2053 0.401755220491796 2994 712864
SGTC_3137 9097352 49.47 µM -0.249410231803397 0.399632175606844 no 2054 0.40152173567429 3153 44120435
SGTC_1503 4585-0012 61.3 µM -0.249775444099685 0.399466396933626 no 2055 0.401380505360718 3038 2922052
SGTC_2512 diallyl trisulfide 49.23 µM -0.249975833821416 0.399375442902802 no 2056 0.401303018636066 2846 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent
SGTC_2876 9059903 25.97 µM -0.250722703163319 0.39903649773014 no 2057 0.401014253313299 2812 6916095
SGTC_2153 5569715 200 µM -0.251633246169376 0.398623376951102 no 2058 0.400662279288935 2856 2054701
SGTC_2546 rhodinyl acetate 100 µM -0.253063524871465 0.397974677320358 no 2059 0.400109562279254 2991 6708682
SGTC_2354 9060492 162 µM -0.254565240666326 0.39729388098328 no 2060 0.399529454388343 2999 6471895
SGTC_147 4466-0538 29.23 µM -0.254729365218508 0.397219494753447 no 2061 0.39946606703006 3065 6742687 YHR072W ERG7
SGTC_2095 5432005 200 µM -0.25627578547206 0.396518794058391 no 2062 0.398868946721068 2866 783734
SGTC_1982 st072467 71.9 µM -0.257706034083561 0.3958710293617 no 2063 0.398316894422443 2812 3163533
SGTC_732 3970-1727 52.7 µM -0.257858065248398 0.395802190776427 no 2064 0.398258224851786 2978 1275699
SGTC_524 r073-0010 27.8 µM -0.259780569749395 0.394931976055352 no 2065 0.397516519810129 2851 2772106
SGTC_2155 5570423 76 µM -0.26000342309892 0.394831136091863 no 2066 0.397430566566502 2887 797402
SGTC_904 1141-0088 396 µM -0.26136708713237 0.394214239007348 no 2067 0.396904717885978 2913 1378119
SGTC_981 1488-1094 54.9 µM -0.262342269690374 0.393773246542546 no 2068 0.396528788175373 2826 3449522
SGTC_1801 st050089 28.441 µM -0.262691714150091 0.393615255531109 no 2069 0.396394101856343 2875 5008493 YIL048W | YNL267W NEO1 | PIK1
SGTC_311 1315-0136 58 µM -0.263440815534036 0.393276630462897 no 2070 0.396105417514446 3050 6759207
SGTC_125 0133-0007 11.75 µM -0.264546831269722 0.392776812863139 no 2071 0.395679291777646 2999 26541
SGTC_1027 k015-0025 8.67 µM -0.264582449197662 0.392760719762193 no 2072 0.395665570971916 2858 3598955
SGTC_843 0310-0051 143 µM -0.265943878663241 0.3921457283888 no 2073 0.395141215609876 2906 2065037
SGTC_1912 st060209 90.8 µM -0.267170174566927 0.391592010676367 no 2074 0.394669069482889 2940 688787
SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM -0.268322632277366 0.391071833727226 no 2075 0.394225493360298 2866 4620898
SGTC_77 0828-0286 12.516 µM -0.268599910926765 0.390946709398932 no 2076 0.394118790422444 2843 745345
SGTC_993 3909-8757 62.7 µM -0.269054449811976 0.390741619319923 no 2077 0.393943891031741 2918 4288324 YLR208W SEC13
SGTC_2971 9092186 9.93 µM -0.269322723171931 0.390620587377594 no 2078 0.393840673710859 2834 25236400
SGTC_3167 9103034 49.47 µM -0.269513868406357 0.390534358372973 no 2079 0.393767135739857 2861 5127859
SGTC_2321 7390090 138.78 µM -0.270189412196618 0.390229651752957 no 2080 0.393507268865803 2961 649046
SGTC_1224 0823-0416 294 µM -0.270352220893785 0.390156226340751 no 2081 0.393444647020535 3014 3598164
SGTC_126 0417-1624 672.48 µM -0.271415334845247 0.389676866949775 no 2082 0.393035804525897 2974 41912 YDL195W SEC31
SGTC_1345 1488-0192 31.4 µM -0.27157585481971 0.389604502856687 no 2083 0.392974083483091 3030 658348
SGTC_322 k048-0136 19.3 µM -0.272881117968298 0.389016218796812 no 2084 0.392472300775529 2979 6823282
SGTC_2291 7917025 104.35 µM -0.273017145281999 0.388954925694148 no 2085 0.392420018022146 2860 2964612
SGTC_2726 cimetidine 79.27 µM -0.274522729643655 0.388276703189471 no 2086 0.391841469295669 2886 2756 A P450 inhibitor, histamine H2-receptor antagonist.
SGTC_2634 4'-methoxyflavone 100 µM -0.275261807265863 0.387943894437275 no 2087 0.391557552415921 2965 77793 From seeds of Psoralea corylifolia (Fabaceae)
SGTC_2702 st077768 96.8 µM -0.275276521892885 0.387937269233625 no 2088 0.391551900373644 2971 6484119
SGTC_642 0335-0876 158 µM -0.27669506443029 0.387298729386947 no 2089 0.391007130992241 2894 6812350
SGTC_1302 1159-0335 255 µM -0.277622641401845 0.386881356484059 no 2090 0.390651024900109 2901 649284
SGTC_1427 4048-4900 550 nM -0.279147255462741 0.38619562486732 no 2091 0.390065909630503 3017 24132586
SGTC_2019 4016004 108 µM -0.279515642403937 0.386029987257254 no 2092 0.389924567658296 2977 45595336
SGTC_1251 0490-5699 265 µM -0.279684726954716 0.385953968820814 no 2093 0.389859698504383 3070 3883818
SGTC_84 0443-0269 128.823 µM -0.279696429980771 0.385948707439175 no 2094 0.3898552087612 2912 6150058
SGTC_3072 9116419 49.47 µM -0.280827315748538 0.385440389175609 no 2095 0.389421425709203 2959 17170162
SGTC_59 0330-0160 1.33 µM -0.280838467016848 0.385435377805396 no 2096 0.389417149011481 2933 4293482
SGTC_1308 1187-1617 41.4 µM -0.281984517971995 0.384920445652114 no 2097 0.388977690830119 2886 2882570
SGTC_1870 st057514 26.5 µM -0.282898229343769 0.384510051315494 no 2098 0.388627425971999 2865 5393161
SGTC_2897 9048598 12.99 µM -0.283295191163352 0.384331795828762 no 2099 0.388475281629673 2905 6467404
SGTC_2464 5717415 7.67 µM -0.286081966754715 0.38308108634433 no 2100 0.387407671527072 2924 5285744
SGTC_3324 9138759 60.749 µM -0.288958142825857 0.381791530791716 no 2101 0.386306704489704 3048 45595710
SGTC_1353 1498-1206 8.11 µM -0.289058419897437 0.381746594362257 no 2102 0.386268336034478 2935 6756808
SGTC_2408 sulbentine 18.36 µM -0.289396235701818 0.381595223170308 no 2103 0.386139087648159 2955 67686 An antifungal agent of unknown mechanism. YDL205C HEM3
SGTC_2616 abietic acid 100 µM -0.289498233379199 0.381549522797682 no 2104 0.386100065801585 3062 6708678 Abietic acid is an inhibitor of 5α-reductase.
SGTC_946 3434-1334 87.4 µM -0.28979432810169 0.381416866004233 no 2105 0.385986793644699 3068 4047976
SGTC_371 0195-0006 7.36 µM -0.29114897784841 0.380810131698762 no 2106 0.385468691342896 2837 3928593
SGTC_341 1486-1430 230 µM -0.293137621712796 0.379919968764003 no 2107 0.384708480611877 2897 2054753 YPL210C SRP72
SGTC_1260 0700-1617 7.75 µM -0.293993321987643 0.379537132933322 no 2108 0.384381503143524 3044 2853078
SGTC_789 1309-1135 70.6 µM -0.294944751989804 0.379111606752827 no 2109 0.38401804230972 2909 3092424
SGTC_1406 3909-7906 11.9 µM -0.29587199439061 0.378697039352813 no 2110 0.383663919631569 2968 X1406
SGTC_2401 5128683 200 µM -0.296389942616932 0.378465526907766 no 2111 0.383466152552592 2958 708373
SGTC_612 0302-0167 22.4 µM -0.297800241510603 0.37783537293846 no 2112 0.382927815106582 3000 235821
SGTC_91 0417-1751 58.384 µM -0.298840399304072 0.377370814633585 no 2113 0.382530912223383 2916 6795624
SGTC_1696 st025591 34.7925 µM -0.299297182119146 0.377166860975611 no 2114 0.382356652225355 2934 2787147
SGTC_235 0330-0087 5 mM -0.300396739591858 0.376676048846759 no 2115 0.381937275173112 2967 46494818 YHR062C RPP1
SGTC_2583 asiatic acid 100 µM -0.300466711326804 0.376644822129936 no 2116 0.3819105922646 3109 5320556 A kinase inhibitor; arrests cells at G2/M.
SGTC_2776 terbinafine 19.92 µM -0.301936382011151 0.37598912994942 no 2117 0.381350280232053 2973 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_1718 roemerine 11.9335 µM -0.302575657760413 0.37570402925225 no 2118 0.381106633831946 3095 235224 An aporphine alkaloid with mutagenic activity.
SGTC_3037 9091026 49.47 µM -0.302793847938755 0.375606737514704 no 2119 0.381023486052873 3037 25236398 YIL048W NEO1
SGTC_2358 9037157 4 µM -0.302870802125783 0.375572425269213 no 2120 0.38099416170873 3022 2388925
SGTC_279 1273-0055 2.93 µM -0.303116393722057 0.375462927750565 no 2121 0.380900580567286 3010 2847562
SGTC_2676 harmalol 100 µM -0.303165092357075 0.375441216555461 no 2122 0.380882025084507 3050 5459187 A monoamine oxidase inhibitor
SGTC_1626 st003712 1.76 µM -0.303606930109074 0.375244251129773 no 2123 0.380713685603418 3100 24207035
SGTC_1543 azetidyl-2-carboxylic acid 198 µM -0.304218198647574 0.37497180933043 no 2124 0.380480830497192 2920 16486 A toxic proline analog.
SGTC_2252 omeprazole 400 µM -0.304410533471194 0.374886098779031 no 2125 0.38040757190248 2969 4594 A proton pump inhibitor.
SGTC_1916 st067606 49.2 µM -0.304978176209567 0.374633175056491 no 2126 0.380191386935734 3020 19590279
SGTC_3205 9113483 49.47 µM -0.305080609152906 0.374587539904048 no 2127 0.380152379652653 3125 17018033
SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM -0.3051880399339 0.374539680039825 no 2128 0.38011147046271 2987 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_1126 isoteolin 1.0172 µM -0.305261974622654 0.374506743636357 no 2129 0.380083317223062 2938 133323
SGTC_1920 st075728 45.7 µM -0.305354144226127 0.374465685230692 no 2130 0.380048221286484 3134 3400306
SGTC_3331 9141060 1.957 µM -0.305423979634841 0.374434576892666 no 2131 0.380021630324146 2948 4906567 YPR165W RHO1
SGTC_2837 9008476 45.46 µM -0.305781456312551 0.374275350916552 no 2132 0.379885524177115 3127 2992805
SGTC_727 3032-0951 202 µM -0.30704930049897 0.373710805372862 no 2133 0.37940292354639 2995 3652836
SGTC_1042 0350-0096 82 µM -0.307305467301024 0.373596772296069 no 2134 0.379305437301057 2933 3122515
SGTC_2595 hexamethylquercetagetin 100 µM -0.307520651797511 0.373500991112215 no 2135 0.379223553117454 3019 386331
SGTC_2976 9009005 19.48 µM -0.308458555673571 0.373083610242603 no 2136 0.37886671575814 3154 2993148
SGTC_461 N-acetylfarnesylcysteine 136 µM -0.310608206964958 0.372127546611873 no 2137 0.37804924367466 3031 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ).
SGTC_2738 aclarubicin 5.55 µM -0.310748302457129 0.37206526601608 no 2138 0.37799598688754 3015 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31
SGTC_579 4491-1009 110 µM -0.310848843301199 0.372020571825059 no 2139 0.377957768083626 3075 1271041
SGTC_3012 9080433 71.4286 µM -0.31087611205577 0.372008450134088 no 2140 0.377947402560114 3058 17688859
SGTC_591 4299-0174 154 µM -0.311808647364513 0.371593989660035 no 2141 0.377592975911051 3005 5509088
SGTC_2952 9073731 13.78 µM -0.311846421474222 0.371577204285956 no 2142 0.377578621357669 2980 16457353
SGTC_124 0136-0217 7.121 µM -0.312155288850441 0.371439964564344 no 2143 0.37746125489751 3106 3976905
SGTC_3158 9100007 49.47 µM -0.312443071896184 0.371312107995788 no 2144 0.377351910451213 2970 19297233
SGTC_2063 5246145 200 µM -0.314288139311696 0.37049271733028 no 2145 0.376651102817182 3071 711240
SGTC_1122 capsaicin 818.572 nM -0.314999030809213 0.370177168366778 no 2146 0.376381194869134 3091 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_2520 obtusaquinone 4.71 µM -0.316367057708367 0.369570177544951 no 2147 0.375861958991126 3115 5967872
SGTC_2030 5175110 200 µM -0.31660451399199 0.369464851714276 no 2148 0.375771855097702 3093 2831986
SGTC_1514 1189-1591 158 µM -0.317233030750831 0.369186114855183 no 2149 0.375533394189414 3153 767698 YMR146C TIF34
SGTC_1521 st012942 49.4 µM -0.317939734648949 0.368872785417182 no 2150 0.375265325659496 3168 24207259
SGTC_520 3584-0023 682 µM -0.318455858958701 0.368644007787905 no 2151 0.375069586259102 3010 1340790
SGTC_1807 st050092 58.9 µM -0.319663117152099 0.368109059564379 no 2152 0.374611861040195 2986 5008496
SGTC_513 4245-1575 41.7 µM -0.31990202321288 0.368003228158882 no 2153 0.374521302051957 3058 719745
SGTC_829 1635-0120 117 µM -0.3199486236421 0.367982586112342 no 2154 0.374503638644713 3102 285054
SGTC_1265 0819-1001 68.8 µM -0.321961902191427 0.367091152422587 no 2155 0.373740778310588 2984 3106768
SGTC_1688 st021091 57.6 µM -0.322024848284228 0.367063292851766 no 2156 0.373716935081292 3095 3656366
SGTC_3046 9092212 49.47 µM -0.322464911588173 0.366868542980009 no 2157 0.373550257854682 3000 25236637
SGTC_1232 0279-0259 161 µM -0.323645474708981 0.36634625451688 no 2158 0.373103227763457 3020 1560000
SGTC_2025 5147754 141 µM -0.324086589402012 0.366151166089939 no 2159 0.372936239793655 3049 315777 YLR208W SEC13
SGTC_1662 st014054 52 µM -0.324151343812093 0.36612253056218 no 2160 0.372911728432712 2996 2838777
SGTC_164 4100-3994 89.624 µM -0.324230942072349 0.366087331846983 no 2161 0.372881598962954 3091 4615967
SGTC_137 0438-0332 85.389 µM -0.325678681512345 0.36544733174983 no 2162 0.372333737644815 3062 2063393 YER012W | YPR107C PRE1 | YTH1
SGTC_1425 4048-4433 7.33 µM -0.325894751067022 0.365351846262506 no 2163 0.372251993568919 3058 23734946
SGTC_2020 4017018 200 µM -0.326638157592288 0.365023383734138 no 2164 0.371970789794601 3095 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope.
SGTC_745 0469-0705 296 µM -0.326774920277512 0.364962968060309 no 2165 0.371919064853551 3194 3486736
SGTC_121 0557-0495 61.343 µM -0.327392439613337 0.364690217234042 no 2166 0.371685541995177 2994 3104427
SGTC_3253 9135987 49.47 µM -0.327623561733038 0.364588150990305 no 2167 0.371598152337093 3099 4182430
SGTC_1409 3909-8004 61.9 µM -0.3290326875989 0.36396607234949 no 2168 0.371065490616517 3024 2119279
SGTC_492 tmb-8 126 µM -0.329766835393547 0.363642114236992 no 2169 0.370788074193699 3041 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1
SGTC_1720 st037298 9.481 µM -0.331010794450493 0.363093413812492 no 2170 0.370318165980212 3075 597396
SGTC_2848 9016370 25.97 µM -0.331350711650889 0.362943527860092 no 2171 0.370189795151257 3108 7894410
SGTC_2381 9035592 200 µM -0.33350647822255 0.361993435599556 no 2172 0.369376000090508 3051 4749657
SGTC_1001 4048-4355 44.4 µM -0.334590142325168 0.361516162316541 no 2173 0.368967141009249 2976 21824233
SGTC_2224 6650123 117.647 µM -0.33473437184875 0.361452656185237 no 2174 0.368912735359874 3015 2908370
SGTC_3250 9135583 49.47 µM -0.334919969650699 0.361370940680274 no 2175 0.368842728808711 3128 7699353
SGTC_93 0109-0045 59.227 µM -0.335476644573857 0.361125884273641 no 2176 0.36863277995413 2998 88733
SGTC_471 1-acyl-paf 4 µM -0.335500585764102 0.361115346290465 no 2177 0.368623751460112 2986 16759367
SGTC_3334 9142812 21.919 µM -0.336361250859394 0.360736584963465 no 2178 0.368299233102854 3109 45283678
SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM -0.337423370605242 0.360269355790826 no 2179 0.367898884705622 2966 2333 A French combination drug.
SGTC_536 3852-0578 10.6 µM -0.338008353366346 0.360012109432321 no 2180 0.367678446406965 3150 2869208
SGTC_1523 st012844 44.7 µM -0.341713778937306 0.358384124017584 no 2181 0.366283150789827 3124 4274103
SGTC_2339 9000433 200 µM -0.343025629441134 0.357808374740638 no 2182 0.365789589564786 3051 2988954
SGTC_1405 3909-7894 12 µM -0.34357942515146 0.357565420035156 no 2183 0.365581300050459 3089 7104060
SGTC_2407 paclitaxel 400 µM -0.343830359423252 0.357455352111243 no 2184 0.365486933565541 3204 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_974 1326-0144 138 µM -0.344021055701632 0.357371714456477 no 2185 0.365415225658851 3040 5411856
SGTC_3 0833-0587 95.581 µM -0.345397325467479 0.356768298406507 no 2186 0.364897843785901 3065 5382644
SGTC_2585 alliin 100 µM -0.347512383096495 0.355841664592985 no 2187 0.364103208572234 3212 87310 A garlic compound which reacts with lipids.
SGTC_2932 9016711 44.54 µM -0.348116781928146 0.355577025839504 no 2188 0.363876240749165 3156 7117328
SGTC_1990 st072050 59.8 µM -0.348532904120451 0.355394865310811 no 2189 0.36372000355765 3000 17233948
SGTC_2526 patulin 37.61 µM -0.349315886976817 0.355052198423392 no 2190 0.363426086347839 3174 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.
SGTC_1048 3161-0300 24.5 µM -0.349843562197224 0.354821331197843 no 2191 0.363228052206611 3031 2165101
SGTC_1188 1403-0014 4.57 µM -0.350785525776801 0.354409338055957 no 2192 0.362874628405885 3039 9614867
SGTC_511 blebbistatin 171 µM -0.351073849265103 0.354283266032464 no 2193 0.362766473045662 3170 3476986 A myosin inhibitor.
SGTC_474 dl-dihydrosphingosine 5 µM -0.352279305410366 0.353756342629137 no 2194 0.362314403276581 3170 3058739 A sphingolipid protein kinase C inhibitor.
SGTC_2822 7994718 71.43 µM -0.352836578420373 0.353512844625336 no 2195 0.36210547977418 3018 1018011
SGTC_429 1112-0049 25.5 µM -0.352855362445749 0.353504638071254 no 2196 0.362098438295964 2986 2836170
SGTC_948 3448-0295 75.3 µM -0.353006763496197 0.35343849494308 no 2197 0.36204168500884 3016 678569
SGTC_606 k015-0008 38.6 µM -0.354065109823991 0.352976255030863 no 2198 0.36164504444195 3180 1970475
SGTC_3203 9113543 49.47 µM -0.355248834858322 0.35245951208955 no 2199 0.361201591280197 3176 17018012
SGTC_375 3970-0961 9.27 µM -0.356277811077438 0.352010544235954 no 2200 0.360816262369846 3069 2898222
SGTC_834 0312-0008 75.7 µM -0.357147597637745 0.351631195588542 no 2201 0.360490656614164 3032 6385573 YIL048W NEO1
SGTC_234 nsc-17383 10.7 µM -0.3573970172808 0.351522440956056 no 2202 0.360397304687857 3178 408974
SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM -0.358632388838312 0.350983960288873 no 2203 0.359935056843146 3002 91467 include heat shock
SGTC_2797 7859098 81.82 µM -0.359156650032709 0.350755532725905 no 2204 0.359738952115453 3035 972681
SGTC_2293 7624732 200 µM -0.359541164981544 0.350588028741725 no 2205 0.359595144225749 3011 894453
SGTC_2990 9074105 71.4286 µM -0.359983034972378 0.350395575386537 no 2206 0.359429910205128 3114 6502001
SGTC_3282 9108498 15.4605 µM -0.360043695699418 0.350369158031781 no 2207 0.359407228625096 3118 16459645
SGTC_2447 5741742 33.78 µM -0.36034203003167 0.350239245893048 no 2208 0.359295686001499 3140 1776504
SGTC_1943 st076331 65.2 µM -0.360447415323125 0.350193359188148 no 2209 0.359256286925472 3150 24208415
SGTC_823 0417-1665 178 µM -0.361070997971327 0.349921884545685 no 2210 0.359023186548861 3110 3429856
SGTC_405 ebelactone b 50 µM -0.362089718504248 0.349478552976641 no 2211 0.358642493276728 3049 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).
SGTC_2569 tetrandrine 100 µM -0.362610225169418 0.349252115633062 no 2212 0.358448035432722 3085 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_1321 1326-2144 215 µM -0.36264697456405 0.349236130476817 no 2213 0.358434307488647 3143 3513030
SGTC_3129 9127257 49.47 µM -0.364937855646609 0.34824017799016 no 2214 0.357578897740979 3042 837894
SGTC_1837 st055472 66.5 µM -0.36522457898701 0.348115599513102 no 2215 0.357471886156333 3217 676091
SGTC_1856 st057054 55.7 µM -0.368274018107304 0.346791664560411 no 2216 0.356334461895003 3266 1266018
SGTC_1827 berberine 7.24 µM -0.36949536626572 0.346261931008339 no 2217 0.355879263193361 3050 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_3301 9125354 19.7965 µM -0.369625213443919 0.346205630243097 no 2218 0.355830880979261 3040 41905162
SGTC_2995 9067767 71.4286 µM -0.36966513154771 0.346188322734845 no 2219 0.355816007605179 3114 11673567
SGTC_593 1203-0218 61.7 µM -0.372445778266773 0.344983495074055 no 2220 0.354780487676554 3197 3666956
SGTC_2207 7258803 200 µM -0.373131813014506 0.344686483749305 no 2221 0.354525171167888 3138 3666799
SGTC_2335 9018011 154.17 µM -0.373262977794908 0.344629708269305 no 2222 0.354476363974054 3142 6458208
SGTC_1800 st050079 29.0735 µM -0.374853612637202 0.343941471100987 no 2223 0.353884669707752 3160 3645560
SGTC_1253 0550-0034 176 µM -0.375783565482995 0.343539337560684 no 2224 0.353538903344726 3177 5969915
SGTC_3033 9090887 49.47 µM -0.375850673999119 0.343510325098544 no 2225 0.353513956354924 3075 19325384
SGTC_1505 k297-0037 20.6 µM -0.376104242542388 0.343400710260248 no 2226 0.353419700201354 3089 4089396
SGTC_87 0100-0052 35.5 µM -0.377970094260668 0.342594529028347 no 2227 0.352726405098485 3189 200187 YGR083C | YDR527W GCD2 | RBA50
SGTC_2170 morpholine 200 µM -0.378201865630204 0.342494437192775 no 2228 0.35264031982386 3175 121171 Reacts with secondary amines.
SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM -0.379141033848377 0.342088965118414 no 2229 0.352291568192403 3167 17037758
SGTC_2715 st079500 56.4 µM -0.380954508453264 0.341306539510528 no 2230 0.351618502355657 3043 28246688
SGTC_3237 9133362 49.47 µM -0.38113594995484 0.341228293835291 no 2231 0.351551186417668 3161 43845137
SGTC_2338 7999974 200 µM -0.381810745935804 0.340937351607854 no 2232 0.351300873729812 3100 315925
SGTC_2543 pimpinellin 60.67 µM -0.382537337822228 0.340624183009711 no 2233 0.351031419672479 3069 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo.
SGTC_297 0986-0032 24 µM -0.383473321725543 0.340220926186479 no 2234 0.350684423699946 3055 2847425
SGTC_3076 9116187 49.47 µM -0.3836842776033 0.340130063724559 no 2235 0.350606233515671 3181 27241210
SGTC_758 0868-0029 16 µM -0.383690120064344 0.340127547404395 no 2236 0.350604068114477 3181 762687
SGTC_449 xestospongin c 11.1929 µM -0.384381429624064 0.339829853963295 no 2237 0.350347881171725 3171 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1
SGTC_1100 amiodarone 5.07 µM -0.385273495989372 0.339445857717503 no 2238 0.350017397953569 3175 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death.
SGTC_1700 st030840 7.9285 µM -0.385507939184471 0.339344967629616 no 2239 0.349930562778492 3182 5499307
SGTC_2324 6149169 200 µM -0.385831002114263 0.339205959867478 no 2240 0.349810916689575 3123 2888231
SGTC_3077 9117319 49.47 µM -0.386107298240872 0.339087092320254 no 2241 0.349708602477918 3102 17154678
SGTC_1970 st070122 35.8 µM -0.386493432841263 0.338920997126479 no 2242 0.349565632667837 3242 102928
SGTC_2951 9072950 58.06 µM -0.386752233079196 0.338809692132036 no 2243 0.349469821491735 3132 16488155
SGTC_730 1436-0052 41.2 µM -0.387182473717813 0.338624685074224 no 2244 0.349310562099477 3109 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2
SGTC_2386 9075165 157.42 µM -0.388800168776912 0.337929411446043 no 2245 0.348711987983503 3134 16452277
SGTC_799 1310-0557 151 µM -0.389646605708707 0.337565839016646 no 2246 0.348398942118613 3241 5354492
SGTC_1483 3453-0561 55.9 µM -0.390204679448426 0.337326210921641 no 2247 0.348192600826418 3169 4546991
SGTC_2937 9044753 11.33 µM -0.390417213543191 0.337234969461077 no 2248 0.348114030620408 3037 6465530 YGL099W LSG1
SGTC_976 1348-1067 47.6 µM -0.390553653821154 0.337176400326126 no 2249 0.348063594427835 3090 5310671 YGL099W LSG1
SGTC_1046 2001-0062 216 µM -0.39065936009126 0.337131026960221 no 2250 0.348024521143995 3060 739778
SGTC_868 0527-0199 213 µM -0.391557570512021 0.336745574717847 no 2251 0.347692571632042 3116 2849450
SGTC_956 1185-0240 191 µM -0.392510178295303 0.336336966049106 no 2252 0.347340646164108 3092 1416193
SGTC_3336 9143619 71.43 µM -0.393244208429566 0.336022245195019 no 2253 0.347069560388515 3214 45595730
SGTC_1995 st072814 61.1 µM -0.393552111087941 0.335890263852519 no 2254 0.346955871678883 3098 5769371
SGTC_1438 4092-1045 4 µM -0.393782248482268 0.335791629517978 no 2255 0.346870905690655 3099 1351342
SGTC_3075 9116269 49.47 µM -0.394537349462317 0.335468081080282 no 2256 0.346592178926535 3277 17015205 YNL244C SUI1
SGTC_3248 9135562 49.47 µM -0.396140066623388 0.334781747394296 no 2257 0.346000851004589 3147 17650701
SGTC_3097 9117246 49.47 µM -0.397177011093095 0.334337988994393 no 2258 0.345618466718055 3105 16423892
SGTC_2953 9074162 66.49 µM -0.397563594278335 0.334172610643228 no 2259 0.345475950336027 3214 16451992
SGTC_1014 4130-3005 69.3 µM -0.398517478802737 0.333764681374887 no 2260 0.345124388392827 3091 743608
SGTC_2808 7946468 45.46 µM -0.398904820246511 0.33359909062427 no 2261 0.344981668665418 3147 2970879
SGTC_2657 nystatin 74.44 µM -0.401885755047264 0.332325810021663 no 2262 0.343884053378397 3168 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_1865 st057639 52.2 µM -0.402267422887747 0.332162923168422 no 2263 0.343743613515813 3100 688818
SGTC_2266 7929956 200 µM -0.402731900855565 0.331964737671768 no 2264 0.343572731629343 3117 2967153
SGTC_2213 7173844 200 µM -0.402966137454074 0.33186481039751 no 2265 0.343486567883439 3130 892728
SGTC_2703 st077852 53.4 µM -0.405837312701236 0.330640916852871 no 2266 0.342431070360387 3218 6281836
SGTC_336 4111-0029 111 µM -0.406307416523602 0.330440698043266 no 2267 0.342258368346648 3135 3131175
SGTC_2134 5324836 1.464 µM -0.407517497373597 0.329925543836061 no 2268 0.341813972817802 3099 699272
SGTC_1769 st044406 64.4 µM -0.408162172393213 0.329651225097189 no 2269 0.341577308884668 3107 670903
SGTC_2489 cantharidin 73.42 µM -0.41006397633518 0.328842513716164 no 2270 0.340879508733514 3151 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_2866 9034245 58.44 µM -0.410441669881091 0.328682000821183 no 2271 0.340740992031 3158 6462273
SGTC_1423 4048-0112 5.59 µM -0.412496928864878 0.327809107593162 no 2272 0.339987615628375 3216 X1423
SGTC_3257 9139206 32.98 µM -0.413049281914967 0.3275746766623 no 2273 0.339785253650522 3233 4910041
SGTC_516 3992-2719 87.3 µM -0.413060774385921 0.327569799723208 no 2274 0.339781043719093 3026 5350887 YDR037W KRS1
SGTC_1226 3909-7979 35.4 µM -0.413843912469421 0.327237536994705 no 2275 0.339494211036648 3244 6615510
SGTC_2906 7926292 26.41 µM -0.414668991524502 0.326887627964972 no 2276 0.339192117574934 3246 2966319
SGTC_794 k038-0031 316 µM -0.414693966951198 0.326877038469576 no 2277 0.339182974712514 3244 6624242
SGTC_3234 9132280 49.47 µM -0.415226174280753 0.326651417536687 no 2278 0.338988169790568 3201 17612295
SGTC_296 1222-0039 74.9 µM -0.416004426802341 0.326321603737623 no 2279 0.338703381957889 3165 5984176
SGTC_3102 9121669 49.47 µM -0.416401253728559 0.326153485633797 no 2280 0.338558205596213 3144 41905072
SGTC_37 0566-0070 1.56 µM -0.417990289154466 0.325480635477046 no 2281 0.337977108602981 3202 1626686
SGTC_2367 9070478 135.38 µM -0.418154619253123 0.325411085068918 no 2282 0.33791703645063 3127 572802
SGTC_1908 st060353 56.5 µM -0.41816854509845 0.325405191429713 no 2283 0.337911945938695 3337 4227716
SGTC_1090 efavirenz 20.7 µM -0.420363225620615 0.324476914192463 no 2284 0.337110064209632 3178 64139 A non-nucleoside reverse transcriptase inhibitor.
SGTC_2438 5259590 200 µM -0.420984401191529 0.324214375058256 no 2285 0.336883236216718 3232 1201127
SGTC_1419 3993-2473 62.6 µM -0.421520913265776 0.323987689172234 no 2286 0.33668737161289 3197 704026
SGTC_140 0062-0056 502.533 µM -0.421573964828875 0.323965277488 no 2287 0.336668006470338 3101 3758964
SGTC_2681 menadione 3.18 µM -0.421855965643458 0.323846156682955 no 2288 0.336565076416597 3239 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_1849 st056239 19.2 µM -0.422276100606879 0.323668719682213 no 2289 0.336411750229517 3115 5393181
SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM -0.423488738132147 0.323156807316582 no 2290 0.335969356761395 3238 616764
SGTC_2341 7987486 176.74 µM -0.423825725910924 0.323014608030285 no 2291 0.335846457451335 3292 1258686
SGTC_2016 5121758 140 µM -0.424420658820159 0.322763626361571 no 2292 0.335629528506849 3171 2795203
SGTC_1899 st063254 59.6 µM -0.424810985779238 0.322599004724758 no 2293 0.335487234283723 3111 3093813
SGTC_3303 9125618 40.5795 µM -0.425184942862103 0.322441319746755 no 2294 0.335350929850137 3201 22695467
SGTC_1549 4'-methoxyflavonol 74.6 µM -0.425185506896348 0.322441081936821 no 2295 0.335350724280428 3206 97141
SGTC_3078 9116413 49.47 µM -0.428219364482623 0.321162990491316 no 2296 0.334245709612128 3095 17177322
SGTC_2768 sulfasalazine 50.2 µM -0.428295640385938 0.321130884482519 no 2297 0.334217946276282 3317 5384001 An antioxidant and salicylic acid derivative.
SGTC_3003 9075612 71.4286 µM -0.430031278681305 0.320400682360131 no 2298 0.333586444190173 3222 6501993
SGTC_123 0083-0120 66.675 µM -0.430895218354555 0.320037472227394 no 2299 0.3332722802095 3178 16001701
SGTC_494 Boc-Gly-Val-Val-CHO 140 µM -0.43238523841981 0.319411455973814 no 2300 0.332730722511136 3146 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA.
SGTC_2295 7971645 200 µM -0.432645023092226 0.319302362787401 no 2301 0.332636337724636 3167 2978226 YKL099C UTP11
SGTC_721 1187-1332 279 µM -0.43379789513533 0.318818418048309 no 2302 0.332217605119526 3126 25730
SGTC_2540 epiandrosterone 100 µM -0.43437319999275 0.318577035945517 no 2303 0.332008727942097 3203 441302 A steroid.
SGTC_1517 deoxycholic acid methyl ester 49.2 µM -0.436201109256168 0.317810606672395 no 2304 0.331345411599752 3277 229346 A bile salt which induces apoptosis.
SGTC_2574 2',4'-dihydroxychalcone 14.64 µM -0.436342757041943 0.317751247288457 no 2305 0.331294032140826 3215 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_1397 3532-0190 20.1 µM -0.439206088938656 0.316552336109316 no 2306 0.330256106740457 3083 5322280
SGTC_2223 6903751 107.57 µM -0.43923529379727 0.316540117583445 no 2307 0.330245527018508 3238 5598863
SGTC_138 0850-0259 40.9225 µM -0.439336967584444 0.316497581572534 no 2308 0.330208695835991 3278 6813004
SGTC_1931 st074438 57.1 µM -0.440041827657452 0.316202764700506 no 2309 0.32995340654617 3232 2787313
SGTC_2966 9084041 48.03 µM -0.440646090618027 0.315950116856613 no 2310 0.329734614980487 3053 17741380
SGTC_1075 aripiprazole 15.2 µM -0.441155519088509 0.315737186938594 no 2311 0.3295502063433 3172 60795 An atypical antipschotic. YIL048W NEO1
SGTC_1511 0906-3109 28.5 µM -0.44136267511142 0.315650617751125 no 2312 0.329475229529742 3214 2882180
SGTC_3189 9110682 49.47 µM -0.441965462675948 0.315398774200071 no 2313 0.329257099202235 3271 17122418
SGTC_3206 9114350 49.47 µM -0.443327827986394 0.314829896444128 no 2314 0.328764315152427 3262 17087243
SGTC_3284 9108171 64.8615 µM -0.443420835173202 0.314791075780415 no 2315 0.328730684166735 3228 8687505
SGTC_2377 9073351 62.6 µM -0.443695637660046 0.314676386764535 no 2316 0.328631324911784 3162 7337946 YHR072W ERG7
SGTC_331 k048-0133 24.5 µM -0.443699801534031 0.314674649106187 no 2317 0.328629819489388 3173 6813582
SGTC_85 0868-0259 160.055 µM -0.444068829075121 0.314520663682379 no 2318 0.32849641095626 3213 83173
SGTC_1436 4092-1007 8.32 µM -0.445220478400627 0.314040318430285 no 2319 0.328080214508752 3188 2881121
SGTC_1666 st014829 29 µM -0.446182999463153 0.31363909882278 no 2320 0.327732531084652 3184 3858230
SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM -0.44756752237637 0.313062357435169 no 2321 0.327232673340747 3266 66535 A nucleotide analog.
SGTC_63 0099-0242 26.702 µM -0.448167582684321 0.312812536249174 no 2322 0.327016128217776 3300 3898502 YLR359W ADE13
SGTC_1144 3486-0183 12.5 µM -0.449155504980506 0.312401424992946 no 2323 0.326659741334719 3228 6744069
SGTC_3084 9116877 49.47 µM -0.44960831386971 0.31221307232382 no 2324 0.326496446140882 3236 27241325
SGTC_376 3970-0862 59.1 µM -0.450069689851099 0.312021206513541 no 2325 0.326330095611572 3288 3135186
SGTC_2727 riluzole 51.77 µM -0.450326310014401 0.311914511630778 no 2326 0.326237585368633 3255 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.
SGTC_1906 st060206 94.7 µM -0.451459743423614 0.311443453258203 no 2327 0.325829116425968 3294 5133468
SGTC_1297 1068-0111 14.1 µM -0.45177185295347 0.311313793728959 no 2328 0.325716674459783 3178 767057
SGTC_3029 9088683 49.47 µM -0.45276999336181 0.310899293854742 no 2329 0.325357186424182 3309 25236615
SGTC_1637 st007924 17.4 µM -0.453624108665002 0.310544793964991 no 2330 0.325049699101532 3197 683336
SGTC_2816 7982706 58.44 µM -0.453957388674086 0.310406514040787 no 2331 0.324929748327035 3277 2981853
SGTC_2470 5664817 21.68 µM -0.454227847872226 0.310294318549282 no 2332 0.324832420721986 3283 2859561
SGTC_2973 9094665 17.96 µM -0.45437973348643 0.310231319072854 no 2333 0.324777768318223 3370 25237061 YIL048W NEO1
SGTC_97 0535-0701 19.132 µM -0.454881359605617 0.310023292971735 no 2334 0.324597296966085 3237 2832013 YGL099W LSG1
SGTC_1233 0325-0408 14.2 µM -0.456407206204254 0.309390893010139 no 2335 0.324048592372766 3311 12874
SGTC_797 k781-0471 270 µM -0.457945868979269 0.308753752445965 no 2336 0.323495665814991 3204 23738129
SGTC_2437 5741531 144.16 µM -0.461509191268443 0.307280437101023 no 2337 0.322216664327566 3371 2262990
SGTC_3085 9117376 49.47 µM -0.46167218633361 0.307213118146956 no 2338 0.322158209843033 3310 16480349
SGTC_803 4488-1585 147 µM -0.46170535410838 0.307199420245984 no 2339 0.322146315511183 3305 747204
SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM -0.46185058935214 0.307139442966241 no 2340 0.322094234687314 3523 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W
SGTC_2473 5854593 8.94 µM -0.462027809954699 0.307066263796019 no 2341 0.322030688763616 3139 2872951
SGTC_1036 k216-0215 33.5 µM -0.462376979831491 0.306922104616577 no 2342 0.321905502280233 3247 622330
SGTC_2115 tiliquinol 12.7705 µM -0.463028333223842 0.306653264955361 no 2343 0.321672029168094 3257 71208 A bioactive hydroxyquinoline.
SGTC_209 4077-0173 175.592 µM -0.463542570200968 0.306441092183955 no 2344 0.321487754214092 3259 15993494
SGTC_919 tnp00227 403.569 nM -0.463617936452762 0.306410001723418 no 2345 0.321460750680618 3211 1269246 A methoxyflavone. YNL221C POP1
SGTC_921 1561-0023 372 µM -0.464328267048239 0.306117041106726 no 2346 0.32120628743188 3201 24050882
SGTC_782 0083-0095 30.5 µM -0.464716698142876 0.305956893444097 no 2347 0.321067174413456 3223 3591729 An indicator and reagent.
SGTC_3191 9110352 49.47 µM -0.464827771250392 0.305911105528212 no 2348 0.32102739921904 3284 17122424
SGTC_1431 4049-0260 9.09 µM -0.467436301839289 0.30483665843988 no 2349 0.320093877661319 3265 3854841
SGTC_2561 acetosyringone 100 µM -0.469302532941912 0.304068993334084 no 2350 0.319426702500818 3176 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent.
SGTC_1980 st071811 45.7 µM -0.470045764706048 0.303763508639595 no 2351 0.31916116064638 3373 4974850
SGTC_3154 9100113 49.47 µM -0.470583536390904 0.303542558011357 no 2352 0.318969083400262 3203 25237525
SGTC_356 1634-0012 32.5 µM -0.471085421445297 0.303336416653012 no 2353 0.318789867715458 3341 735457
SGTC_2887 9044784 58.44 µM -0.472181945459455 0.30288625456466 no 2354 0.318398462754216 3255 6465546
SGTC_2137 5261020 140 µM -0.472367602506892 0.302810065361241 no 2355 0.318332212395768 3224 763655
SGTC_3199 9111318 49.47 µM -0.473730490725277 0.302251031641343 no 2356 0.317846053691131 3292 8548020
SGTC_414 piperonyl butoxide 100 µM -0.473745535961777 0.302244862924693 no 2357 0.317840688623169 3214 5794 A potent inhibitor of cytochrome P450.
SGTC_293 4049-0273 38.5 µM -0.473819674929706 0.30221446593685 no 2358 0.317814251538017 3247 1380311
SGTC_2265 7929201 200 µM -0.474674475971173 0.30186409653223 no 2359 0.317509506635719 3154 1265108
SGTC_233 rapamycin 362 pM -0.475029875271579 0.301718477731957 no 2360 0.31738283969652 3334 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C
SGTC_1469 k284-2957 126 µM -0.475937460485398 0.30134675356966 no 2361 0.317059466668528 3277 23884841
SGTC_1834 st055981 52.8 µM -0.477555220787524 0.300684671371511 no 2362 0.316483404383847 3383 471719 YDL150W RPC53
SGTC_3117 9124945 49.47 µM -0.477963893753725 0.300517522405945 no 2363 0.316337951878921 3185 17592065
SGTC_558 k064-0027 21.3 µM -0.478236861011678 0.30040590102705 no 2364 0.316240814783771 3311 5088526
SGTC_1657 st012939 43.4 µM -0.478811861500962 0.300170833962179 no 2365 0.316036238779442 3356 24207257
SGTC_1681 tripelennamine 100 µM -0.479196514684727 0.30001362959464 no 2366 0.315899416744979 3337 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist.
SGTC_1530 rhein 70.4 µM -0.480377152026768 0.299531346313676 no 2367 0.3154796188423 3312 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death.
SGTC_1296 1068-0102 11.9 µM -0.48257486585746 0.298634530572797 no 2368 0.31469881444273 3297 767053
SGTC_192 3455-0609 60.9 µM -0.482780287335403 0.298550767162458 no 2369 0.314625874492546 3375 3769639
SGTC_3255 9139072 49.47 µM -0.483296375355753 0.298340372397268 no 2370 0.314442656661869 3334 17646060
SGTC_3302 9125395 16.351 µM -0.483828646115688 0.298123451107666 no 2371 0.314253741617375 3242 17599668
SGTC_211 3455-0679 143.504 µM -0.484526718668575 0.29783906802537 no 2372 0.314006053471514 3353 748649
SGTC_2185 6113692 200 µM -0.487178471362635 0.296759917633742 no 2373 0.313065930238836 3363 874150
SGTC_456 gingerol 170 µM -0.487347161584129 0.296691328498721 no 2374 0.313006165671629 3420 442793 A herb.
SGTC_735 3076-0345 636 µM -0.488601605684048 0.296181501696819 no 2375 0.312561888013795 3400 2888990
SGTC_2532 xanthone 78.9 µM -0.48875669966519 0.29611849686806 no 2376 0.312506978365726 3325 7020 An insecticide.
SGTC_1015 4130-4525 82 µM -0.488856766834812 0.296077849200393 no 2377 0.312471552681082 3248 1363237
SGTC_1992 st073643 23.3 µM -0.490795625904357 0.295290783202452 no 2378 0.311785502025477 3276 3161292
SGTC_1734 st037168 69.4 µM -0.491793174322483 0.294886211055523 no 2379 0.311432781148063 3311 708907
SGTC_2276 7947513 42.08 µM -0.492087094510125 0.294767055638426 no 2380 0.31132888756079 3297 2105100
SGTC_781 4335-2806 94.4 µM -0.492334422050055 0.294666806111451 no 2381 0.311241474974487 3377 845254
SGTC_351 caspofungin 25 nM -0.493163375697381 0.294330920211715 no 2382 0.310948576822029 3289 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1
SGTC_2974 9094440 9.66 µM -0.49317267044527 0.294327155051011 no 2383 0.310945293342754 3400 25236134
SGTC_2870 9038528 12.99 µM -0.493511959159207 0.294189729591832 no 2384 0.310825445908601 3370 6463316
SGTC_3184 9108758 49.47 µM -0.494611464263223 0.293744590010616 no 2385 0.310437204088434 3302 902885
SGTC_2653 dihydrofissinolide 100 µM -0.496554591414148 0.292958669343001 no 2386 0.309751590650651 3369 6857746
SGTC_2244 6635614 200 µM -0.49710730510755 0.29273529615376 no 2387 0.309556691724718 3122 836499
SGTC_2558 carylophyllene oxide 100 µM -0.497211716982378 0.292693108121 no 2388 0.309519879827412 3376 6708694 An oxygenated terpenoid and antifungal agent.
SGTC_841 0251-0215 91.2 µM -0.498457709941732 0.292189877781352 no 2389 0.309080734778561 3337 3888614
SGTC_2664 lyso-paf C-16 73.48 µM -0.499428627786277 0.291798023775189 no 2390 0.308738727797262 3267 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_3092 9117248 49.47 µM -0.499676963882799 0.29169783681973 no 2391 0.308651277725372 3359 17141857
SGTC_3277 9138724 49.47 µM -0.499685954614087 0.291694209963537 no 2392 0.308648111896601 3270 15943418
SGTC_478 N-arachidonylglycine 10 µM -0.50027290880868 0.291457478444735 no 2393 0.308441463553364 3315 5283389
SGTC_2199 6590217 200 µM -0.500480827496149 0.291373641772568 no 2394 0.308368276390272 3297 703109
SGTC_1181 1222-0449 220 µM -0.501388371198601 0.291007835129506 no 2395 0.308048911142025 3431 658318
SGTC_878 0828-0289 13.7 µM -0.501735857567905 0.290867829475161 no 2396 0.307926668905069 3297 745350 YLR208W SEC13
SGTC_3218 9131285 49.47 µM -0.501826729894368 0.290831221320771 no 2397 0.307894704442255 3449 17156417
SGTC_1005 4092-0690 4.4 µM -0.502547518163039 0.290540926208663 no 2398 0.3076412178509 3283 1529343
SGTC_915 methyl methanesulfonate (MMS) 110 mM -0.503850169322888 0.290016631970582 no 2399 0.307183334849352 3327 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks.
SGTC_627 1391-0720 175 µM -0.504604666184905 0.289713163207184 no 2400 0.306918265914448 3322 997839
SGTC_78 0336-0123 156.75 µM -0.505202516342964 0.289472805724728 no 2401 0.306708301557349 3146 6765896
SGTC_3276 9139060 49.47 µM -0.505641091995576 0.289296541955964 no 2402 0.306554314557297 3362 4870619
SGTC_1159 4092-0538 61.2 µM -0.509714489111384 0.287661856539794 no 2403 0.305125750323457 3363 717301
SGTC_1682 st012968 530 nM -0.510311281753877 0.287422726202979 no 2404 0.304916700083695 3248 24207270
SGTC_835 0312-0010 67.2 µM -0.511191010426312 0.28707039707062 no 2405 0.304608656398029 3296 1626196
SGTC_574 1315-0397 40 µM -0.511739578199868 0.286850800628651 no 2406 0.304416641316685 3343 6794277
SGTC_1444 4112-3581 28 µM -0.512696049633986 0.286468107328226 no 2407 0.304081976722913 3374 2877249
SGTC_688 0527-0193 473 µM -0.512874956111767 0.286396552052955 no 2408 0.304019396445032 3301 4007154
SGTC_1163 k060-0048 49.9 µM -0.513634363172055 0.286092914748658 no 2409 0.303753824914865 3354 6809982
SGTC_1550 gossypolone 36.6 µM -0.513868477498601 0.285999338567166 no 2410 0.303671973894076 3347 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_3151 9099821 49.47 µM -0.513986199230216 0.285952290343428 no 2411 0.303630819757571 3368 17174189
SGTC_1429 4049-0205 9.46 µM -0.514349877143347 0.285806967441807 no 2412 0.303503697955422 3402 22774478
SGTC_962 1254-0300 21.5 µM -0.514688201393665 0.285671807212559 no 2413 0.303385459747773 3327 7340576
SGTC_2824 7998404 51.95 µM -0.5162024939538 0.285067221695965 no 2414 0.302856494309687 3293 837851
SGTC_86 0417-1630 471.922 µM -0.516420105319542 0.284980389908144 no 2415 0.302780513292732 3389 3634867
SGTC_120 rhodamine 6G 52.259 µM -0.517478312156374 0.284558321683734 no 2416 0.302411152368052 3283 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase
SGTC_575 k072-0246 11.9 µM -0.517585956915183 0.284515404058501 no 2417 0.302373590918499 3368 6796779
SGTC_2720 fluspirilene 36.88 µM -0.517962121142619 0.284365452853517 no 2418 0.302242349002412 3370 3396 An atypical antipsychotic.
SGTC_485 niflumic acid 177 µM -0.517987570107271 0.284355309438734 no 2419 0.302233470902529 3406 4488 A COX2 inhibitor.
SGTC_3239 9133757 49.47 µM -0.518224362352806 0.284260937387927 no 2420 0.30215086941208 3379 17036923
SGTC_1935 st074532 41.6 µM -0.519728558590852 0.283661799406996 no 2421 0.301626389520901 3391 2829742
SGTC_289 k017-0060 526 µM -0.519742167589498 0.283656381554642 no 2422 0.301621646234248 3319 5512909
SGTC_2803 7707263 71.43 µM -0.521238699060351 0.28306090291229 no 2423 0.301100249306131 3284 2199229
SGTC_2902 5787006 60.46 µM -0.522460615034653 0.282575140752214 no 2424 0.300674830859091 3266 591003
SGTC_1524 corynanthine 62.1 µM -0.522755547142241 0.282457953100343 no 2425 0.300572188875376 3424 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist.
SGTC_2010 4012422 159 µM -0.524047574759576 0.281944857432985 no 2426 0.300122725272102 3326 952393
SGTC_3051 9093778 49.47 µM -0.524082275488282 0.281931083121289 no 2427 0.300110657962258 3358 17217378
SGTC_1137 ixabepilone 100 µM -0.524336585353371 0.28183014576018 no 2428 0.300022227441618 3416 154225 A novel microtubule stabilizer.
SGTC_3070 9117005 49.47 µM -0.525142025140534 0.281510576056856 no 2429 0.299742231747285 3425 8779016
SGTC_971 1315-0384 26.7 µM -0.526344756155607 0.281033701065018 no 2430 0.299324345833128 3346 6769120
SGTC_963 1269-2853 151 µM -0.529253185098383 0.279882143757739 no 2431 0.298314913234949 3319 3668223
SGTC_1069 diphenylcyclopropenone 8.49 µM -0.531086623844537 0.279157393774814 no 2432 0.297679376508044 3359 65057 A dermal irritant. YDR527W RBA50
SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM -0.531316117107718 0.279066740419799 no 2433 0.297599869299428 3447 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_3350 9150499 3.57 µM -0.531554058788317 0.278972764928504 no 2434 0.29751744539947 3378 4910996 YPR165W RHO1
SGTC_118 0083-0097 135.343 µM -0.532480492250358 0.278607015095432 no 2435 0.297196624674763 3473 5207356
SGTC_3326 9140064 16.379 µM -0.533757820361006 0.278103117631211 no 2436 0.296754549846528 3322 1868434
SGTC_199 4063-0024 41.6 µM -0.53395754322676 0.278024368493923 no 2437 0.296685454306304 3434 306215
SGTC_2594 a-mangostin 100 µM -0.534958245780348 0.277629963344216 no 2438 0.296339365155765 3448 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis.
SGTC_2484 5809818 12.04 µM -0.535029805120702 0.277601770261639 no 2439 0.296314623724848 3359 2870548
SGTC_3317 9138495 8.753 µM -0.537389834745339 0.276672745984326 no 2440 0.295499181749976 3431 17020139
SGTC_2028 5153890 36.43 µM -0.53760563667636 0.276587871767703 no 2441 0.295424668977118 3381 2830968 YPR165W RHO1
SGTC_954 1189-0853 2.85 µM -0.537755262904068 0.27652903173879 no 2442 0.295373010634628 3423 2828194
SGTC_950 1165-0508 94.1 µM -0.537817679843663 0.27650448829373 no 2443 0.295351462461729 3387 6148369
SGTC_1091 telmisartan 47.6 µM -0.538719652400499 0.276149936007583 no 2444 0.295040155649908 3449 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension.
SGTC_2678 equilin 100 µM -0.538974977193448 0.276049612088247 no 2445 0.29495206030586 3463 3247 Equilin is an estrone commonly used hormone replacement therapy
SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM -0.539972345129199 0.275657891207814 no 2446 0.29460805218418 3397 442882
SGTC_2286 7945697 125 µM -0.540267656342506 0.275541958817961 no 2447 0.294506230161121 3369 1245733
SGTC_975 1335-0046 28.5 µM -0.540790815946226 0.275336637277132 no 2448 0.294325886886075 3352 16486740
SGTC_2195 6536160 144.242 µM -0.541913065717666 0.27489644830322 no 2449 0.293939197735501 3316 3834386
SGTC_210 3551-0445 56.827 µM -0.545202565594491 0.27360818313689 no 2450 0.292807103594493 3481 2865180 YOR207C RET1
SGTC_246 cycloheximide 667 µM -0.546206449516464 0.273215628387171 no 2451 0.292462016645782 3337 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells.
SGTC_1074 carmofur 3.8 µM -0.546372354197998 0.273150780562185 no 2452 0.29240500481371 3447 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_1518 st038567 90.8 µM -0.546605642846228 0.273059607002007 no 2453 0.292324845756741 3435 77966
SGTC_3169 9102970 49.47 µM -0.547411962527525 0.27274459842964 no 2454 0.292047869323645 3457 17027839
SGTC_1909 st060837 51.5 µM -0.549131990671394 0.272073230353298 no 2455 0.29145743628422 3346 678937
SGTC_2396 5342950 42.78 µM -0.54996238038818 0.271749403765292 no 2456 0.291172588336516 3390 1886677
SGTC_839 0122-0028 230 µM -0.550063842260935 0.271709849893909 no 2457 0.291137792861669 3361 759448
SGTC_2323 6148992 148.28 µM -0.550746200156312 0.271443914127789 no 2458 0.29090383455963 3339 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42
SGTC_1611 st001856 99.4 µM -0.551071375300382 0.271317229053087 no 2459 0.290792373514421 3384 647478
SGTC_1841 st054148 70 µM -0.552523388926052 0.270751898467072 no 2460 0.290294907217385 3408 675442
SGTC_2389 9091542 195.52 µM -0.552906373495113 0.270602884380411 no 2461 0.290163761468544 3381 3626624 YOL127W RPL25
SGTC_2330 7979373 200 µM -0.553219971146474 0.270480898311151 no 2462 0.290056396620743 3366 1863007
SGTC_3212 9128307 49.47 µM -0.553833086228091 0.270242482627627 no 2463 0.289846541309249 3236 27243542
SGTC_2725 haloperidol 53.21 µM -0.555136401252021 0.269736025435575 no 2464 0.28940068306284 3405 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_1026 k007-1105 30.6 µM -0.555471498108595 0.269605886495235 no 2465 0.289286100018358 3452 7066794
SGTC_1668 st014914 51.6 µM -0.556251472440095 0.26930309585415 no 2466 0.28901947814108 3463 2839556
SGTC_2777 climbazole 1.536 µM -0.556474351839981 0.269216604093748 no 2467 0.288943311587431 3428 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2
SGTC_2017 5132927 60.65 µM -0.556914176939314 0.269045964126577 no 2468 0.28879303397162 3354 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis
SGTC_555 4296-0685 37 µM -0.557969276157245 0.268636836254111 no 2469 0.288432682133425 3423 2908540 YHR072W ERG7
SGTC_2452 5863136 48.41 µM -0.558015573880911 0.268618890897523 no 2470 0.288416874760238 3409 2184096
SGTC_518 1021-0119 62.6 µM -0.558024457671886 0.268615447540165 no 2471 0.288413841625429 3351 1097762
SGTC_1473 k844-0725 134 µM -0.558677468621295 0.26836240125555 no 2472 0.288190929541215 3520 54682906
SGTC_2921 7974240 10.71 µM -0.559821107510125 0.267919522267382 no 2473 0.287800732435104 3471 2979074 YDR527W RBA50
SGTC_582 0987-0078 156 µM -0.562668265391756 0.266818549598888 no 2474 0.286830398788846 3525 1625765
SGTC_1080 nisoldipine 24.4 µM -0.562787132641741 0.266772634369484 no 2475 0.286789921641214 3369 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class.
SGTC_2737 bleomycin 30.5 nM -0.564352722703508 0.266168261820321 no 2476 0.286257053537362 3465 16211318 Bleomycin acts by induction of DNA strand breaks.
SGTC_2529 gangaleoidin 93.61 µM -0.565864908662793 0.265585164013382 no 2477 0.285742808975656 3419 4565183
SGTC_1532 4',5'-dihydroxyflavone 78.7 µM -0.566375186431627 0.265388547579516 no 2478 0.285569379553563 3478 165521
SGTC_1054 3429-0080 167 µM -0.567233433979861 0.26505802070773 no 2479 0.285277797790116 3501 1162877
SGTC_1465 k213-0056 144 µM -0.568711235562877 0.264489382677942 no 2480 0.284776060847239 3376 24048857 YMR208W ERG12
SGTC_2922 7999257 32.47 µM -0.569970096634441 0.264005480103928 no 2481 0.284348990091057 3477 2988377
SGTC_136 0097-0015 404.482 µM -0.573133138487859 0.262791610119249 no 2482 0.28327727555439 3504 4861337
SGTC_1155 4088-0394 48.2 µM -0.573885431027465 0.262503326099738 no 2483 0.283022666241275 3387 2326248
SGTC_2344 7990960 76.95 µM -0.576214804322648 0.261611720975921 no 2484 0.2822349999319 3409 140813
SGTC_1039 k821-0043 94 µM -0.577157917495025 0.261251171784383 no 2485 0.281916391089444 3479 15992768
SGTC_1774 st048371 48.465 µM -0.577261857630115 0.261211451423242 no 2486 0.281881287936686 3403 4242727
SGTC_1993 st073995 70.8 µM -0.577859867121378 0.260982984478048 no 2487 0.281679366275253 3438 3098394
SGTC_1318 1280-3875 124 µM -0.57806859657052 0.260903264490793 no 2488 0.28160890388819 3467 373245
SGTC_205 1486-1330 71.903 µM -0.578316669170068 0.260808534474241 no 2489 0.28152517119104 3473 4118834
SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM -0.578533247565313 0.260725845433431 no 2490 0.281452078649261 3397 4174840
SGTC_1664 st014217 9.02 µM -0.580958800572484 0.259800698370507 no 2491 0.280634110499268 3547 3982782
SGTC_805 3852-0218 479 µM -0.583227909704418 0.258936757704266 no 2492 0.279869942569437 3426 6615355
SGTC_819 1013-0258 27.7 µM -0.5839903929431 0.258646783772041 no 2493 0.279613387802986 3465 5753198
SGTC_2068 5226020 147 µM -0.584634950993284 0.258401788224983 no 2494 0.279396600718472 3468 1810509
SGTC_2861 9024595 19.48 µM -0.5852808940834 0.258156386900605 no 2495 0.27917942973753 3422 16482810
SGTC_2486 5283202 22.39 µM -0.58576575409822 0.257972262338911 no 2496 0.279016470042761 3425 1377751
SGTC_2691 st077356 60.2 µM -0.586866434723504 0.257554534200273 no 2497 0.278646707075959 3538 2839272
SGTC_2662 daunorubicin 22.37 µM -0.586900957118892 0.257541438013366 no 2498 0.2786351134729 3423 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_1768 st044301 37.178 µM -0.5888621163891 0.256798033951436 no 2499 0.277976886343602 3447 3931349
SGTC_1782 st039423 80.636 µM -0.589128010834969 0.256697329101536 no 2500 0.277887702198136 3411 2068169
SGTC_215 1287-0124 461.5 µM -0.589342199015259 0.256616222435559 no 2501 0.277815871104818 3456 5560863
SGTC_473 2-arachidonoylglycerol 10 µM -0.589624567434417 0.256509318347491 no 2502 0.277721188641248 3395 5282280 An endocannabinoid.
SGTC_2714 st079313 56.9 µM -0.589730780428223 0.256469112337485 no 2503 0.277685577874087 3494 2939799
SGTC_301 4119-0100 24.5 µM -0.591303566971121 0.255874132100167 no 2504 0.277158520017841 3482 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1
SGTC_258 haloperidol 50.781 µM -0.591382040263753 0.255844464777561 no 2505 0.277132235590262 3465 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_3332 9141069 11.198 µM -0.591787299214266 0.255691282659745 no 2506 0.276996514564423 3461 17332883
SGTC_3022 9087993 49.47 µM -0.591809369402461 0.255682941817859 no 2507 0.276989124203449 3513 17173644
SGTC_631 k072-0230 41.5 µM -0.592084872179253 0.255578834812745 no 2508 0.276896878244597 3508 5773147
SGTC_689 0833-0039 98 µM -0.592636541642069 0.255370436501114 no 2509 0.276712209265037 3486 5374726
SGTC_1011 4112-3381 17.4 µM -0.592647651667957 0.255366240497156 no 2510 0.276708490851632 3565 2877139
SGTC_1773 st048542 73.5835 µM -0.594068179865412 0.254830036314248 no 2511 0.276233256214164 3430 3237138
SGTC_1597 7-benzyloxygramine 47.5 µM -0.59435528683373 0.254721734210875 no 2512 0.276137253877562 3491 260807
SGTC_1763 st044482 94.5 µM -0.594856732604824 0.254532637334931 no 2513 0.275969620591122 3480 88505
SGTC_2857 9024691 58.44 µM -0.594865213972464 0.254529439615446 no 2514 0.275966785700393 3494 16478292
SGTC_2853 9015042 58.44 µM -0.595839798048928 0.254162133600632 no 2515 0.275641126990836 3432 6457456
SGTC_70 0141-0289 43.283 µM -0.596273854737481 0.253998633711966 no 2516 0.275496147145374 3472 352408
SGTC_1486 3970-0793 4.53 µM -0.596554644714327 0.253892895526075 no 2517 0.275402380100289 3530 2844330
SGTC_1176 0848-0131 83.3 µM -0.601148245688266 0.252166351028215 no 2518 0.27387062589416 3523 6769040
SGTC_2864 9034755 47.6 µM -0.601365917779889 0.25208469104346 no 2519 0.273798146943072 3527 4930451
SGTC_3333 9141820 12.094 µM -0.602272930023795 0.251744574382929 no 2520 0.273496238414851 3461 1939433
SGTC_2774 tamoxifen 10.92 µM -0.604307171940982 0.250982644719152 no 2521 0.272819719490909 3556 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.
SGTC_2062 5245942 200 µM -0.605372823376966 0.250583990313666 no 2522 0.272465652089833 3590 1376160
SGTC_3275 9138069 49.47 µM -0.606537070193561 0.250148835657643 no 2523 0.272079086954526 3530 17617007
SGTC_3171 9103192 49.47 µM -0.607304964982905 0.249862043014909 no 2524 0.271824271997963 3576 13018434
SGTC_1730 st033808 45.1 µM -0.60817918676296 0.249535752052904 no 2525 0.271534318566852 3478 1045166
SGTC_206 4546-0025 72.014 µM -0.609412107884457 0.249075966682121 no 2526 0.271125657189405 3549 6620745 YIL048W NEO1
SGTC_440 fluspirilene 35.1 µM -0.610152490266569 0.248800077368992 no 2527 0.270880399117312 3626 3396 An atypical antipsychotic.
SGTC_272 doxorubicin 8.13 µM -0.610268658399247 0.248756804310769 no 2528 0.27084192746928 3538 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_556 4058-0063 51.5 µM -0.610293575805703 0.248747523006904 no 2529 0.270833675873912 3549 6615692
SGTC_1051 3253-3903 78 µM -0.610750448685543 0.248577378435466 no 2530 0.270682401068294 3486 5509239
SGTC_1743 st037606 46.3785 µM -0.611685534428853 0.248229335440177 no 2531 0.27037291720384 3545 590142 YLR208W | YDL195W SEC13 | SEC31
SGTC_1096 rimcazole 32.2 µM -0.612186947107359 0.24804281453689 no 2532 0.270207038312728 3467 18528119 A dopamine reuptake inhibitor.
SGTC_3204 9114183 49.47 µM -0.612204194941823 0.248036399831726 no 2533 0.27020133323644 3536 17027248
SGTC_3280 9140961 49.47 µM -0.612722692542295 0.24784360482378 no 2534 0.270029857612049 3469 4901226
SGTC_2089 5281248 129.67 µM -0.615147482689823 0.24694304836552 no 2535 0.269228663359052 3557 2737878
SGTC_2043 5101342 149 µM -0.615282883241332 0.246892812865072 no 2536 0.269183959758873 3483 678451
SGTC_3082 9117008 49.47 µM -0.615569479906802 0.246786499532954 no 2537 0.269089349808637 3492 41448529
SGTC_2603 homopterocarpin 100 µM -0.61565242554484 0.246755735335664 no 2538 0.269061971296589 3537 101795 A weak amylase inhibitor.
SGTC_2643 anethole 100 µM -0.616179503728664 0.246560292186792 no 2539 0.268888027173529 3519 637563 An anti-fungal, anti-helmenthic and channel blocker.
SGTC_2251 lansoprazole 556 µM -0.618020856702878 0.245878160966923 no 2540 0.268280795155336 3422 3883 Gastric proton pump inhibitor. YBR192W RIM2
SGTC_2237 6667747 47.222 µM -0.618898026336303 0.245553569045102 no 2541 0.267991769399431 3404 729940 YDL015C TSC13
SGTC_1161 k007-0610 110 µM -0.619759574019623 0.245234982149875 no 2542 0.267708043743799 3603 5843850
SGTC_1244 0416-0015 52.5 µM -0.619869389231528 0.245194390171822 no 2543 0.267671890179831 3551 96201
SGTC_1588 farnesol 29.9 µM -0.620005890197776 0.245143939136731 no 2544 0.26762695451389 3569 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_1221 2958-7315 257 µM -0.620344648780624 0.245018757397175 no 2545 0.267515452741115 3549 4562705
SGTC_2188 6126565 140.678 µM -0.620643861646101 0.244908217626981 no 2546 0.267416986855535 3515 874518
SGTC_2202 7226349 200 µM -0.620979862271893 0.244784119157866 no 2547 0.267306436535486 3498 844334
SGTC_131 0141-0277 33.849 µM -0.62251855705714 0.244216250337734 no 2548 0.266800472717681 3539 1547771
SGTC_202 3594-0513 34.79 µM -0.623448233272299 0.243873489682702 no 2549 0.266495005135436 3518 708429
SGTC_1121 fusaric acid 630.51 nM -0.623591169273906 0.243820813899567 no 2550 0.266448055753268 3521 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler.
SGTC_2805 7950783 58.44 µM -0.623829252884985 0.243733087283117 no 2551 0.266369863062817 3533 1178958 YDL195W SEC31
SGTC_3115 9123671 49.47 µM -0.624303905251219 0.243558243089096 no 2552 0.26621400985495 3630 3286988
SGTC_1278 0874-0585 172 µM -0.625627698117304 0.243070965404217 no 2553 0.265779583440133 3535 766306
SGTC_419 nsc-638432 893 µM -0.625947039241221 0.242953497443804 no 2554 0.265674839737994 3520 368090
SGTC_585 0kpi-0023 191 µM -0.627259796398159 0.242470929373235 no 2555 0.265244476149544 3518 64601
SGTC_2615 purpurogallin-4-carboxylic acid 100 µM -0.628872360471952 0.241878863936782 no 2556 0.264716311175728 3600 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase.
SGTC_2285 7945142 200 µM -0.629801370994511 0.241538126935036 no 2557 0.264412274278866 3573 2970608
SGTC_2112 5488546 200 µM -0.630468711594609 0.241293524648515 no 2558 0.264193983738184 3527 600757
SGTC_1437 4092-1038 11.6 µM -0.63100920340555 0.241095515315465 no 2559 0.264017253387361 3560 3977136
SGTC_1706 st031321 9.9705 µM -0.631079869250229 0.241069633394434 no 2560 0.263994151479227 3578 6103185
SGTC_1936 st074407 74.3 µM -0.631615309708633 0.240873573217156 no 2561 0.263819140052888 3553 809813
SGTC_2555 cholic acid 100 µM -0.631680146559764 0.240849838045637 no 2562 0.263797951815819 3579 6708657 Influences liver metabolism.
SGTC_3242 9133940 49.47 µM -0.632385421769161 0.240591736410347 no 2563 0.263567528797715 3608 17248444
SGTC_890 0929-0006 47.2 µM -0.632422770256048 0.240578072604179 no 2564 0.263555329402286 3515 1378169
SGTC_2996 9066192 71.4286 µM -0.63265623774458 0.240492668960387 no 2565 0.263479076827289 3543 6472854
SGTC_2008 4012253 172 µM -0.632760871382342 0.240454398779939 no 2566 0.263444906197614 3567 603940
SGTC_2482 5981709 142.65 µM -0.633069316480118 0.240341603027604 no 2567 0.263344189201134 3538 877755
SGTC_3026 9090633 49.47 µM -0.635765379305153 0.239356903971337 no 2568 0.262464677933952 3547 25236842
SGTC_3120 9124077 49.47 µM -0.636128223478748 0.239224548683779 no 2569 0.262346425599992 3598 18774327 YGL155W CDC43
SGTC_364 0083-0097 67.7 µM -0.636439523200417 0.239111027233426 no 2570 0.262244993555282 3585 5207356
SGTC_1670 st016595 4.04 µM -0.637154150142834 0.238850536144341 no 2571 0.262012219794934 3577 597879
SGTC_2000 st075254 36.4 µM -0.637335230451062 0.238784554603742 no 2572 0.261953253754457 3553 17234175
SGTC_658 3253-0951 102 µM -0.637430826347817 0.238749725657757 no 2573 0.261922127153113 3573 1184878
SGTC_2430 5571206 200 µM -0.637872546296457 0.23858882764823 no 2574 0.261778325102358 3623 1731771
SGTC_1175 0741-0056 27.6 µM -0.63836082938962 0.238411037936401 no 2575 0.261619411550739 3626 765927
SGTC_1378 2093-0007 380 nM -0.638618109352764 0.238317388416792 no 2576 0.26153569874959 3564 3618014
SGTC_1202 1988-0068 29.6 µM -0.639709110015934 0.237920489780435 no 2577 0.261180865850746 3495 2850480
SGTC_531 3788-1495 174 µM -0.642052054305669 0.237069368750393 no 2578 0.260419692570528 3563 2896655
SGTC_1292 0kpi-0043 232 µM -0.64233210709829 0.236967746080222 no 2579 0.260328785820052 3554 3333905
SGTC_635 k038-0028 24.7 µM -0.642629977624321 0.236859684177746 no 2580 0.260232113275767 3575 4035102
SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM -0.647827522379784 0.234978478923934 no 2581 0.25854825611376 3723 16725076
SGTC_200 k038-0079 37.545 µM -0.647887764605406 0.234956723288714 no 2582 0.258528772471943 3549 3436683
SGTC_1809 st050081 57.6 µM -0.648333484475091 0.234795792392689 no 2583 0.258384640632705 3655 5036894
SGTC_1269 0831-0796 3.05 µM -0.64839051298096 0.234775206170224 no 2584 0.258366202405558 3600 927758
SGTC_2051 5263410 176 µM -0.64974071331561 0.234288100717915 no 2585 0.257929860294433 3657 227584
SGTC_2450 5739737 12.93 µM -0.651355603761201 0.233706239633417 no 2586 0.257408481229713 3599 2262825
SGTC_738 1315-0003 72.4 µM -0.651431329645157 0.233678974521437 no 2587 0.257384046028324 3610 6251474
SGTC_2086 5274770 176.623 µM -0.651435447679457 0.23367749187334 no 2588 0.257382717257032 3579 689278
SGTC_1358 1509-0022 2.48 µM -0.652202343449971 0.233401471329452 no 2589 0.257135324194983 3608 3258434
SGTC_2476 5806916 10.51 µM -0.654855350543199 0.232447999647981 no 2590 0.25628044484346 3538 2870194
SGTC_2957 9076800 11.52 µM -0.65633214091404 0.231918191759115 no 2591 0.255805220887713 3537 16459615
SGTC_1752 st044819 83.042 µM -0.656944196399121 0.231698810255992 no 2592 0.255608399322894 3542 441209 YML126C ERG13
SGTC_421 streptovitacin 30 mM -0.657152066985878 0.231624328681699 no 2593 0.255541571396758 3626 91467 include heat shock
SGTC_3079 9117512 49.47 µM -0.657300593796537 0.231571118597457 no 2594 0.255493827381379 3637 7185044
SGTC_1172 0370-0043 85 µM -0.658234732790622 0.23123661730594 no 2595 0.255193654812214 3640 376585
SGTC_1214 0358-0031 63.7 µM -0.658955596533921 0.230978671089472 no 2596 0.254962141402875 3657 4301366
SGTC_2070 5230947 200 µM -0.660452003248842 0.230443725989726 no 2597 0.254481904825433 3676 2835538
SGTC_1897 st060201 15 µM -0.660772190825629 0.230329353291083 no 2598 0.254379209736677 3578 611878
SGTC_1184 1269-1718 139 µM -0.662695527192027 0.229642995753948 no 2599 0.253762787499987 3627 5403821
SGTC_3288 9119690 36.221 µM -0.662772630879681 0.229615504608845 no 2600 0.253738092412275 3586 17595618 YKL019W RAM2
SGTC_2889 9059656 51.95 µM -0.663323422921749 0.229419174587839 no 2601 0.253561719171545 3666 3949838
SGTC_2011 4012611 177 µM -0.663790491847197 0.2292527614486 no 2602 0.253412206016495 3626 2049887
SGTC_1021 4476-0760 85.3 µM -0.664838642158949 0.228879559872061 no 2603 0.253076851979343 3590 746768
SGTC_1327 1436-0082 2.18 µM -0.665704809131504 0.228571412275984 no 2604 0.252799899506348 3599 15992205
SGTC_1803 st050068 52.4 µM -0.666008824766679 0.228463310934344 no 2605 0.252702729902408 3701 3984059 YIL048W | YNL267W NEO1 | PIK1
SGTC_1495 4469-0029 237 µM -0.666297778840224 0.228360591786141 no 2606 0.252610392515829 3612 793680
SGTC_3294 9122953 26.2835 µM -0.668315118765225 0.227644179094509 no 2607 0.251966232299567 3628 16459826
SGTC_776 4476-4378 112 µM -0.668915174647979 0.22743132722328 no 2608 0.251774794846373 3614 2892008
SGTC_670 4204-0025 119 µM -0.67001154003683 0.227042714094046 no 2609 0.251425216871213 3629 719039
SGTC_596 1155-0152 116 µM -0.670757457631446 0.226778533395786 no 2610 0.251187526492485 3629 280313
SGTC_1665 st014639 11.4 µM -0.672407619020429 0.226194714494823 no 2611 0.250662116852367 3696 981133 YIL048W NEO1
SGTC_929 2805-0021 398 µM -0.673327961731812 0.225869471077067 no 2612 0.250369333762021 3656 3098024
SGTC_369 0957-0393 4.5 µM -0.673925792985451 0.225658342980121 no 2613 0.25017924646906 3615 6997992
SGTC_2924 9010168 62.78 µM -0.674512825404105 0.225451137259969 no 2614 0.249992667296544 3663 2993929
SGTC_2911 7942208 15.64 µM -0.675928506806574 0.224951885379766 no 2615 0.249543018782314 3619 1243384
SGTC_1697 st025554 27.742 µM -0.676297278967879 0.224821937745552 no 2616 0.24942596000884 3613 1269519
SGTC_1369 1866-0067 208 µM -0.676438327062358 0.224772246587558 no 2617 0.249381195048788 3655 3531355
SGTC_858 0438-0351 2.77 µM -0.677895838296529 0.224259131089295 no 2618 0.248918869443605 3647 2799119
SGTC_1275 0867-0008 21.1 µM -0.680992839657445 0.223171045518832 no 2619 0.247938010592875 3620 3422836
SGTC_400 oxethazaine 37.5 µM -0.681493796210027 0.222995324682799 no 2620 0.247779545456712 3626 4621 A local anesthetic.
SGTC_1852 st056254 31.4 µM -0.68197398211149 0.222826963574649 no 2621 0.247627701371764 3600 442583
SGTC_2984 9022109 38.96 µM -0.683036866562782 0.222454556432238 no 2622 0.247291773561529 3689 6459207
SGTC_119 0121-0043 24.815 µM -0.683810712805789 0.222183644220873 no 2623 0.247047350491657 3717 1092378
SGTC_1299 1079-1439 3.74 µM -0.684146046880403 0.222066307181399 no 2624 0.246941473758273 3621 323161
SGTC_2142 5622915 118.518 µM -0.684731475287491 0.221861544223769 no 2625 0.246756691684818 3642 5322196
SGTC_1663 st014140 55.4 µM -0.6848130434323 0.221833023020875 no 2626 0.246730951748025 3716 4207120
SGTC_1914 st062367 72.6 µM -0.68579364664304 0.22149030824018 no 2627 0.246421621641782 3650 978205
SGTC_1770 st043884 66.3 µM -0.685877271900906 0.221461095741018 no 2628 0.246395251775485 3647 670149
SGTC_232 clozapine 119 µM -0.686766489385853 0.221150604984874 no 2629 0.246114945055253 3619 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_2841 9004761 38.96 µM -0.68836430807214 0.220593316113708 no 2630 0.245611697111321 3574 2991039
SGTC_1268 0828-0275 2.46 µM -0.689264168861847 0.220279816210527 no 2631 0.245328521003063 3698 745337
SGTC_496 calpeptin 138 µM -0.689491953769184 0.22020049941877 no 2632 0.24525686748851 3619 73364 A calpain inhibitor.
SGTC_245 methotrexate 289.6 µM -0.690107187142945 0.219986351397982 no 2633 0.245063391889699 3650 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2
SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM -0.690311301466752 0.219915330491379 no 2634 0.244999221151652 3640 6708514
SGTC_2939 9044578 71.43 µM -0.690339264022288 0.219905602037145 no 2635 0.244990430812616 3652 2653634
SGTC_1591 genipin 88.4 µM -0.691075764831726 0.219649454934243 no 2636 0.244758964729246 3656 442424 A DNA cross-linking agent.
SGTC_2683 piperine 63.03 µM -0.691947543664615 0.219346481121681 no 2637 0.244485135947748 3634 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_2980 9014342 25.29 µM -0.692101049845586 0.219293157201306 no 2638 0.244436936214549 3666 2996599
SGTC_625 k213-0058 121 µM -0.692150088170928 0.219276124175766 no 2639 0.244421539645319 3720 3655420
SGTC_1442 4112-3290 3 µM -0.692362787450002 0.219202253778046 no 2640 0.244354764474924 3653 704353
SGTC_2187 6125751 200 µM -0.692850874452813 0.219032795394267 no 2641 0.244201570791598 3660 874498
SGTC_276 colchicine 750 µM -0.694135858801278 0.218587023547877 no 2642 0.243798506241372 3697 2833 A microtubule depolymerizer.
SGTC_2039 Aminomethylbenzodioxan 200 µM -0.694338676774854 0.218516712048639 no 2643 0.243734920600729 3645 15053
SGTC_2539 epi(13)torulosol 80 µM -0.694463482259991 0.218473451839983 no 2644 0.243695797173743 3650 6708597
SGTC_2652 actinonin 100 µM -0.698410721660549 0.217107802372747 no 2645 0.242460186571553 3654 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase.
SGTC_1762 st045503 25.4615 µM -0.698547160068419 0.217060686336506 no 2646 0.242417537805594 3710 4645554
SGTC_2478 5763493 32.33 µM -0.698975509433463 0.216912803599841 no 2647 0.242283668111126 3633 1365576 YLR208W SEC13
SGTC_3175 9106517 49.47 µM -0.699597039561841 0.216698331000373 no 2648 0.242089495949154 3677 41468073
SGTC_1106 tegaserod maleate 11.7 µM -0.701417028736883 0.216071009662902 no 2649 0.241521398950549 3711 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation.
SGTC_2328 6201408 200 µM -0.702555706316425 0.215679061114652 no 2650 0.241166337150348 3660 2890418
SGTC_3305 9127027 53.8275 µM -0.703792788803373 0.215253707780872 no 2651 0.240780912591649 3624 41905295
SGTC_353 1988-1175 58.3 µM -0.703890985314214 0.215219965166588 no 2652 0.240750332920422 3558 2788357
SGTC_391 gliotoxin 8.33 µM -0.704786720597637 0.214912311361423 no 2653 0.24047148689012 3731 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion
SGTC_3161 9100388 49.47 µM -0.705578041294854 0.214640732956138 no 2654 0.240225291946285 3707 25236368
SGTC_2385 9074692 200 µM -0.70558070801806 0.214639818083714 no 2655 0.240224462510184 3689 17046906
SGTC_349 k015-0014 24 µM -0.705909562567128 0.214527015365083 no 2656 0.240122190204518 3672 2196908
SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM -0.706513305839013 0.214320010869553 no 2657 0.239934490527039 3721 6708784 An antioxidant flavonoid
SGTC_2116 5511452 16.8835 µM -0.707550299605062 0.213964729751971 no 2658 0.239612283056649 3684 870744
SGTC_1382 3002-2117 298 µM -0.707665226957425 0.213925375974725 no 2659 0.239576588175141 3727 1497314
SGTC_2422 chlorphenesin carbamate 384.24 µM -0.709497981198787 0.213298368289886 no 2660 0.23900775191975 3709 2724 A muscle relaxant with antifungal properties.
SGTC_176 1486-1328 72.834 µM -0.709660226685984 0.21324291379463 no 2661 0.238957431006796 3713 22310231
SGTC_495 decylubiquinone 155 µM -0.710501718194304 0.212955432159282 no 2662 0.238696532914289 3669 2971 A Co-enzyme Q analog. A free radical scavenger.
SGTC_2622 2-methoxyxanthone 59.94 µM -0.71067196403251 0.212897298006644 no 2663 0.238643768439602 3700 71034 A hepatoprotective.
SGTC_3296 9122258 64.045 µM -0.712181830199666 0.212382126749124 no 2664 0.238176093444496 3718 4730474
SGTC_171 k064-0041 9.68 µM -0.712331370305465 0.212331142853135 no 2665 0.238129801342787 3672 53325
SGTC_2842 9000675 19.48 µM -0.713129742842399 0.212059068416302 no 2666 0.237882738097568 3673 2989072
SGTC_3310 9130229 44.1445 µM -0.714825039149683 0.211482011165473 no 2667 0.237358580515758 3746 7761258
SGTC_1371 2421-0008 32.7 µM -0.717802624325828 0.210470707932172 no 2668 0.236439497508646 3692 2827552
SGTC_55 0767-0285 6.563 µM -0.718958997353065 0.210078725394834 no 2669 0.236083091829493 3674 3116166
SGTC_1196 1588-0294 184 µM -0.720223119419822 0.209650709619065 no 2670 0.235693815702091 3713 6144269
SGTC_1476 4112-3294 3.34 µM -0.721158417587433 0.209334359810502 no 2671 0.235406026224669 3743 704369
SGTC_320 4092-0846 5.34 µM -0.721386506920152 0.209257254832293 no 2672 0.235335872994945 3701 1359356
SGTC_3185 9108267 49.47 µM -0.72308358551078 0.208684087162004 no 2673 0.23481426660872 3674 4910486
SGTC_2305 7443522 69.23 µM -0.724155030872641 0.208322696524285 no 2674 0.234485281392639 3669 5415886
SGTC_1300 1094-0077 113 µM -0.724798482626349 0.208105842527425 no 2675 0.234287833399759 3674 5532636
SGTC_2514 salinomycin 42.74 µM -0.724878113625793 0.208079014816828 no 2676 0.234263404431673 3790 23682228 A polyether potassium ionophore.
SGTC_1824 st053723 68.6 µM -0.724895597640868 0.208073124719561 no 2677 0.234258040924796 3695 675225
SGTC_3028 9087778 49.47 µM -0.726043940309605 0.20768648117907 no 2678 0.233905916964974 3698 17217395
SGTC_578 3460-0051 92 µM -0.726731228761245 0.207455276393324 no 2679 0.23369530949448 3785 2876744
SGTC_2934 9036370 36.88 µM -0.728522588017763 0.206853376157202 no 2680 0.233146873315814 3746 6462800
SGTC_386 1509-0011 3.07 µM -0.730081253351379 0.206330503495392 no 2681 0.232670259786063 3761 3107280
SGTC_1082 camptothecin 424.86 nM -0.730498541055704 0.206190652449008 no 2682 0.232542752218183 3674 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_770 0389-1121 67.2 µM -0.730688386173308 0.206127045792694 no 2683 0.232484755488117 3797 6753108
SGTC_3340 9146634 11.102 µM -0.733331645420397 0.205242644274009 no 2684 0.231678089250953 3746 4907387
SGTC_668 1682-0499 62.6 µM -0.73721444806272 0.203947603053194 no 2685 0.230495974288784 3761 682214
SGTC_1868 st057644 42.7 µM -0.737652623930717 0.203801763498684 no 2686 0.230362784151889 3742 688665
SGTC_458 nppb 133 µM -0.740861532701484 0.202735627458485 no 2687 0.229388700709447 3752 4549 A chloride channel blocker.
SGTC_2772 vinpocetine 57.06 µM -0.74233516637454 0.202247142339021 no 2688 0.228942145123052 3746 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor.
SGTC_404 fumagillin 50 µM -0.743580981782206 0.201834724922693 no 2689 0.228565006195245 3740 12015870 A methionine aminopeptidase binder.
SGTC_1252 0493-0875 34.8 µM -0.743934004840772 0.201717951033234 no 2690 0.228458200928803 3742 3960963
SGTC_1199 1638-0010 4.46 µM -0.74463847111425 0.201485046810155 no 2691 0.22824515220011 3733 3111136
SGTC_2093 5331342 194.4 µM -0.74473827564275 0.201452063382691 no 2692 0.228214977777324 3760 33839
SGTC_1160 4092-0570 10.5 µM -0.744745363505274 0.201449721107037 no 2693 0.228212834952231 3730 4994975
SGTC_445 e6 berbamine 66 µM -0.74582938909129 0.201091683014077 no 2694 0.227885242080247 3831 6610268 A calcium/calmodulin antagonist.
SGTC_609 0986-0026 86.3 µM -0.746341575319164 0.200922648101762 no 2695 0.227730551328522 3725 2848610
SGTC_427 1354-0053 47.3 µM -0.74940583852199 0.199913142681062 no 2696 0.226806316500247 3845 6813657
SGTC_633 0437-0093 97.7 µM -0.7503766428157 0.199593953642218 no 2697 0.226513947147419 3722 2831118
SGTC_3113 9123498 49.47 µM -0.750833265530533 0.199443927573379 no 2698 0.226376503355839 3779 8897275
SGTC_1846 st056244 14.8 µM -0.751091676263342 0.199359055300349 no 2699 0.226298742399714 3786 5393182
SGTC_724 3910-0327 137 µM -0.752841558292287 0.198784897487638 no 2700 0.225772565131795 3789 2885483
SGTC_2804 7954240 19.48 µM -0.753915524914028 0.198433010031584 no 2701 0.225449973886078 3778 828705
SGTC_2687 chenodiol 100 µM -0.755743708702163 0.197834866827751 no 2702 0.224901436290887 3783 5702181 A cholesterol synthesis inhibitor.
SGTC_576 1073-0113 22.7 µM -0.757001361841043 0.197424022371751 no 2703 0.224524523284882 3910 5439563
SGTC_1154 4088-0362 150 µM -0.758639083202359 0.196889793004801 no 2704 0.224034243207039 3772 6618304
SGTC_3147 9097027 49.47 µM -0.759168613603962 0.196717246102864 no 2705 0.22387584937882 3798 25236841
SGTC_2508 celastrol 40.54 µM -0.760381104875792 0.196322502240643 no 2706 0.223513407202914 3723 122724 Celastrol is a natural product and antioxidant.
SGTC_2895 9054447 58.44 µM -0.761741802789925 0.19588007986052 no 2707 0.223107060320364 3799 2697450
SGTC_2268 7933382 153.85 µM -0.762234699656891 0.19571996692412 no 2708 0.222959969771999 3807 935025 YOR257W CDC31
SGTC_1134 3477-0009 42.5 µM -0.763679005766324 0.195251255254011 no 2709 0.222529277376806 3802 3973534
SGTC_1076 itraconazole 331 nM -0.76460518422723 0.194951047567598 no 2710 0.22225334058627 3774 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1
SGTC_56 0957-0365 83.25 µM -0.764667675290666 0.194930802083047 no 2711 0.222234729627408 3737 6752360
SGTC_2589 lobaric acid 100 µM -0.766695442287872 0.194274552138969 no 2712 0.221631307053993 3797 73157 A novel microtubule depolymerizer.
SGTC_1785 bathophenanthroline 24 µM -0.768335989175364 0.193744604736463 no 2713 0.221143799314117 3728 72812 An iron chelator.
SGTC_1366 1683-0113 21.9 µM -0.770173027513005 0.193152231648213 no 2714 0.220598630708576 3799 708623
SGTC_1049 3226-0134 66 µM -0.77217868681251 0.192506748953464 no 2715 0.220004301487001 3824 5702385
SGTC_1987 st072290 61.9 µM -0.772256271606035 0.192481806307301 no 2716 0.219981329557884 3811 54697379
SGTC_1766 st045414 44.774 µM -0.772475156220157 0.192411447994682 no 2717 0.219916527861435 3817 253960
SGTC_1947 st076332 61.6 µM -0.772676544459936 0.192346727612099 no 2718 0.21985691571634 3745 24208416
SGTC_3272 9137413 49.47 µM -0.772902546393922 0.192274112951921 no 2719 0.219790028813092 3745 17614870
SGTC_2706 st078239 82.5 µM -0.772948838842662 0.192259241208439 no 2720 0.219776329670351 3783 15434492
SGTC_1357 1503-1303 39.5 µM -0.773699559699218 0.192018165591229 no 2721 0.219554240229873 3775 292895
SGTC_423 5-fluorouracil 457 µM -0.773901304631556 0.191953411697467 no 2722 0.219494579017515 3762 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_141 0443-0274 32.331 µM -0.774244408584579 0.191843316621326 no 2723 0.219393135664689 3848 1627241
SGTC_247 mechlorethamine 29.705 µM -0.775770524008497 0.191354085791759 no 2724 0.218942245402488 3712 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links.
SGTC_2834 9001755 58.44 µM -0.777046073092382 0.190945766851023 no 2725 0.218565794160405 3747 2989575
SGTC_2522 biochanin a 4.94 µM -0.777849990996984 0.190688697629574 no 2726 0.218328726428214 3766 5280373 A possible chelator.
SGTC_816 0325-0417 81.3 µM -0.778475328042028 0.190488880247471 no 2727 0.218144422961533 3829 68101
SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM -0.779620522379176 0.190123283470583 no 2728 0.217807136285729 3787 16623 A steroid.
SGTC_1786 berberine 21.6 µM -0.781728398216841 0.189451484274667 no 2729 0.217187104282139 3751 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_1764 st044502 93.5 µM -0.78212606486766 0.189324908288021 no 2730 0.217070245003984 3845 8407
SGTC_3157 9099274 49.47 µM -0.785310757090822 0.188313110039054 no 2731 0.216135695162853 3759 17217662
SGTC_95 0471-0001 561.058 µM -0.785556633362736 0.188235132446042 no 2732 0.216063639647337 3754 4015405
SGTC_1102 cgs 12066b 26.1 µM -0.78675001639801 0.187856944136293 no 2733 0.215714109310512 3819 6438352 A 5-HT1B full agonist.
SGTC_3279 9140807 49.47 µM -0.786886906949605 0.187813592939245 no 2734 0.215674036360887 3848 45595718
SGTC_1045 1348-1485 165 µM -0.787307961271981 0.18768029004425 no 2735 0.215550805176915 3826 6810614
SGTC_1370 2001-0092 44.6 µM -0.789518209609689 0.186981499770908 no 2736 0.214904595549797 3872 790957
SGTC_960 1222-0186 7.7 µM -0.791331414726239 0.186409441950651 no 2737 0.214375310536407 3862 3126296
SGTC_2959 9079155 11 µM -0.791764266387747 0.186273039717755 no 2738 0.21424907082663 3826 16189457
SGTC_1463 k081-0032 34.1 µM -0.792692091489144 0.185980867577252 no 2739 0.213978619550625 3610 977755
SGTC_2269 7935389 174.42 µM -0.792989766328646 0.185887190001432 no 2740 0.213891892586154 3777 97605
SGTC_327 1273-0057 3.96 µM -0.793508554143601 0.18572399864074 no 2741 0.213740793727947 3731 3108138
SGTC_2221 6807166 181.081 µM -0.793594946600841 0.185696831420388 no 2742 0.213715637647164 3750 674925
SGTC_367 0335-0881 7.1 µM -0.793754643492058 0.185646619168266 no 2743 0.213669141046082 3798 23828853
SGTC_889 0919-1524 82.7 µM -0.793789152274156 0.185635769947132 no 2744 0.213659094404587 3868 3905452
SGTC_2071 5230951 39.92 µM -0.794932747789964 0.185276457345467 no 2745 0.213326311836995 3858 1799272
SGTC_3353 9151644 39.2805 µM -0.795933715185467 0.18496231254222 no 2746 0.213035281752363 3895 4909158
SGTC_1407 3909-7909 12.3 µM -0.796995077806044 0.184629574989162 no 2747 0.21272694500082 3808 4411780
SGTC_158 k038-0087 26.446 µM -0.797450369743066 0.184486954955511 no 2748 0.212594757911686 3765 X158
SGTC_2925 9010536 32.5 µM -0.797789663394856 0.184380715915947 no 2749 0.212496280363842 3792 2994177
SGTC_1303 1160-0052 261 µM -0.797975891864666 0.184322420562606 no 2750 0.212442240215664 3801 3562476
SGTC_2828 7998861 71.43 µM -0.798384443827926 0.184194571163333 no 2751 0.212323713926512 3739 2988188
SGTC_1101 ebselen 5.29 µM -0.800320764556666 0.183589383432499 no 2752 0.211762487724013 3840 3194 A potent scavenger of hydrogen peroxide and hydroperoxides.
SGTC_1131 3454-3128 32.3 µM -0.800652255471564 0.183485901905382 no 2753 0.211666494986087 3911 710982
SGTC_580 1123-0028 41 µM -0.802947413515535 0.182770420041298 no 2754 0.211002564877546 3905 1677248 YPR107C YTH1
SGTC_1228 0124-0032 52.5 µM -0.803238565213775 0.182679782414469 no 2755 0.210918429535094 3912 X1228
SGTC_561 1550-0330 72.9 µM -0.803374765922441 0.182637391786872 no 2756 0.210879077792283 3782 6812934
SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM -0.805291254859825 0.182041561984931 no 2757 0.210325813545616 3873 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_751 0833-0568 350 µM -0.805676712660565 0.181921871445255 no 2758 0.210214640165993 3911 6954252
SGTC_2424 5537928 59.2 µM -0.805844338014295 0.181869836568709 no 2759 0.210166304587409 3892 5382802
SGTC_1374 2889-5571 141 µM -0.805935577054795 0.18184151772422 no 2760 0.210139998114266 3871 2853281
SGTC_144 4161-2749 112.381 µM -0.807942156536123 0.181219411501912 no 2761 0.209561940789388 3761 797501 YMR168C CEP3
SGTC_2707 st078556 66.6 µM -0.808753754852842 0.180968168155828 no 2762 0.209328400692744 3826 17250899
SGTC_467 ro 31-8220 72.8 µM -0.809760533717987 0.180656807011578 no 2763 0.209038909706663 3782 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7
SGTC_613 3914-0030 117 µM -0.809948539251334 0.180598700783492 no 2764 0.208984876398392 3591 1145395
SGTC_980 1473-0395 201 µM -0.811045452273591 0.180259915347021 no 2765 0.208669784628388 3761 768876
SGTC_3245 9134821 49.47 µM -0.811556168647515 0.180102314971587 no 2766 0.208523175309321 3859 17014901
SGTC_2785 7756463 72.73 µM -0.812138096482943 0.179922845142536 no 2767 0.208356197650393 3822 2201551
SGTC_2810 7959871 45.46 µM -0.812770400634749 0.179727966340726 no 2768 0.208174854510073 3845 2974535
SGTC_547 1120-0019 610 nM -0.813073393602459 0.179634629649773 no 2769 0.208087989955941 3769 3676939
SGTC_3165 9101544 49.47 µM -0.814032708388836 0.179339314593307 no 2770 0.207813106713145 3868 5002184
SGTC_791 1348-1292 225 µM -0.814489728469767 0.179198733145481 no 2771 0.207682227072307 3825 5437054
SGTC_1166 k206-0078 225 µM -0.820839825672742 0.177252591557371 no 2772 0.205868755169152 3884 5404595
SGTC_2734 clemastine 41.6 µM -0.821672296833642 0.176998453804689 no 2773 0.205631715080321 3866 26987 Clemastine is a selective histamine H1 antagonist.
SGTC_871 0574-0004 149 µM -0.822487369260459 0.176749850740679 no 2774 0.205399786192093 3843 9551173
SGTC_3192 9110362 49.47 µM -0.822554873830982 0.176729271254721 no 2775 0.205380584732894 3878 16649480
SGTC_2623 humulene 100 µM -0.822622361426462 0.176708698458145 no 2776 0.205361389167945 3839 6187145 An anti-inflammatory.
SGTC_757 1066-0008 322 µM -0.82439968891657 0.176167446246315 no 2777 0.204856245780183 3911 6842497
SGTC_3091 9116372 49.47 µM -0.824741884030236 0.176063357644171 no 2778 0.204759073639056 3951 17169793
SGTC_903 1134-0042 114 µM -0.826332543965714 0.175580023425276 no 2779 0.204307738642363 3870 701009
SGTC_3254 9136651 49.47 µM -0.826354688358931 0.175573300621558 no 2780 0.204301459559572 3856 16454030
SGTC_90 0870-0863 4.608 µM -0.826362935614484 0.175570796883635 no 2781 0.204299121064693 3857 1738164
SGTC_2812 7970281 58.44 µM -0.826410276410072 0.175556425395513 no 2782 0.204285697973258 3910 2233435
SGTC_1112 tnp00069 1.16933 µM -0.828580695009305 0.174898341026623 no 2783 0.203670857804221 3899 145826
SGTC_872 0588-0139 234 µM -0.829002572982351 0.17477060696638 no 2784 0.203551475642914 3852 2047100
SGTC_1365 1672-3266 55.4 µM -0.831194107278271 0.174108018538263 no 2785 0.202931991597551 3886 6415873
SGTC_1286 0929-0070 131 µM -0.831806871504788 0.173923041433346 no 2786 0.202758982328798 3974 1420408
SGTC_698 k064-0052 127 µM -0.831811564806444 0.173921625133718 no 2787 0.202757657551337 3925 5088751
SGTC_450 aminopyrene 156 nM -0.832704284557849 0.173652362091826 no 2788 0.202505763760585 3796 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1
SGTC_811 0416-0114 265 µM -0.833728778890368 0.173343680097573 no 2789 0.202216918534502 3951 6612453
SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM -0.833783789861154 0.173327115081003 no 2790 0.202201415755007 3913 115019
SGTC_2733 amorolfine 100 µM -0.835012463485373 0.17295739701379 no 2791 0.201855345486358 3921 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_286 k060-0067 22.9 µM -0.83601775359159 0.172655270931699 no 2792 0.201572457744371 3871 5985051
SGTC_38 0929-0051 58.268 µM -0.83622611804725 0.172592691989465 no 2793 0.201513853902372 3908 1379719
SGTC_3059 1327-0034 3 µM -0.836768404970822 0.172429892568118 no 2794 0.20136138008842 3814 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_256 clotrimazole 625 nM -0.83953356881185 0.171601289201705 no 2795 0.200584979972076 3826 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C
SGTC_2728 chlorpromazine 9.18 µM -0.841163837071094 0.171113960456918 no 2796 0.200128078249146 3896 2726 A thorazine and dopamine antagonist.
SGTC_3074 9116018 49.47 µM -0.843635305701971 0.170376865270888 no 2797 0.199436614508257 3936 17027303
SGTC_3235 9132602 49.47 µM -0.84416144891276 0.170220210334949 no 2798 0.199289596855346 3906 4912240
SGTC_338 4055-0136 114 µM -0.845086566157348 0.16994498794004 no 2799 0.199031254134209 3839 2900563
SGTC_355 1311-2252 105 µM -0.845464291058583 0.16983269683988 no 2800 0.198925830974226 3901 5338538
SGTC_955 1216-0110 33 µM -0.845671700640491 0.169771057786674 no 2801 0.198867957199373 3854 3619719
SGTC_422 cantharidin 155 µM -0.846885825984865 0.169410525576507 no 2802 0.198529381807111 3842 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_1568 digitonin 820 nM -0.850491857356651 0.168342620791579 no 2803 0.197525842794666 3879 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1
SGTC_2783 7738165 71.43 µM -0.85169718394999 0.167986638022128 no 2804 0.197191092002976 3902 17201110
SGTC_1727 st034309 9.9045 µM -0.851761961108392 0.167967520378096 no 2805 0.197173111412274 4029 870305
SGTC_999 SEC7.066 22.7 µM -0.852587141556346 0.167724107915518 no 2806 0.196944147863948 3895 740511 YDR170C SEC7
SGTC_17 0960-0276 49.807 µM -0.853207535261456 0.167541253293816 no 2807 0.196772112714664 3888 6821114
SGTC_637 1181-0519 7.26 µM -0.853432984879919 0.167474836178245 no 2808 0.196709618096377 3931 6252091 YGR060W ERG25
SGTC_589 1227-0070 34.1 µM -0.853814980926758 0.16736233944958 no 2809 0.196603756264286 3946 2841384
SGTC_2443 5493264 126.67 µM -0.855978706288483 0.166726047984784 no 2810 0.196004778888593 3938 5340055
SGTC_1863 st057641 20.1 µM -0.856866703900654 0.166465364934971 no 2811 0.195759277994998 3919 3921635
SGTC_2194 5927483 104.545 µM -0.857622757553078 0.166243623229158 no 2812 0.195550402253101 3909 760979
SGTC_1183 1254-0324 198 µM -0.858362328779854 0.166026900295929 no 2813 0.195346211125811 3997 5799357
SGTC_1037 k284-1091 78.7 µM -0.85836285986989 0.166026744731661 no 2814 0.195346064541633 3868 3334711
SGTC_638 3970-0837 4.09 µM -0.860083361659676 0.165523278253912 no 2815 0.194871546080882 3902 4118451 YLR208W SEC13
SGTC_1013 4112-3890 241 µM -0.863212103764494 0.164610255177481 no 2816 0.194010430036969 3868 705171
SGTC_2200 6600604 21.907 µM -0.863404152210568 0.164554318502868 no 2817 0.193957648646889 3885 2904777
SGTC_2950 9072895 21.46 µM -0.863458079180951 0.164538613767992 no 2818 0.193942829270322 3872 17332245
SGTC_89 0302-0250 142.109 µM -0.865367560457029 0.163983156472118 no 2819 0.193418540003562 4005 4203518 YLR208W SEC13
SGTC_330 1488-0319 80.1 µM -0.86556156745477 0.163926789097475 no 2820 0.193365319632385 3970 6846614
SGTC_2945 9067681 61.76 µM -0.865698595337806 0.163886984182495 no 2821 0.193327735265913 4010 16456930
SGTC_630 4356-0227 183 µM -0.865843355972322 0.163844939812035 no 2822 0.193288034782775 3903 779312
SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM -0.865953408560962 0.163812980752636 no 2823 0.1932578562815 3868 279621
SGTC_2992 9074591 71.4286 µM -0.868594958941084 0.163047093788791 no 2824 0.192534356366343 3881 17741321
SGTC_3043 9092303 49.47 µM -0.870054677981851 0.162624865260457 no 2825 0.192135262005024 3940 25236084
SGTC_1108 betulinic acid 729.144 nM -0.870360088257374 0.162536614398519 no 2826 0.192051825405245 3932 64945 Apoptosis-inducing agent of unknown mechanism.
SGTC_2098 5376439 882.5 nM -0.871433418787686 0.162226713776484 no 2827 0.191758772658478 3953 2844116
SGTC_1238 0333-0287 48.8 µM -0.871966059050246 0.162073068514543 no 2828 0.191613446946424 3919 7226
SGTC_2005 4024620 188 µM -0.872534306139649 0.161909256638841 no 2829 0.191458480655751 3910 236743
SGTC_74 000s-0487 160.283 µM -0.875544881351778 0.161043180960868 no 2830 0.190638750496684 3858 677548
SGTC_2263 7948595 193.29 µM -0.876169350731149 0.16086391427768 no 2831 0.190468987909451 3917 2971371
SGTC_818 4072-2707 53.5 µM -0.876570201587619 0.160748910534361 no 2832 0.190360065160899 3855 882871
SGTC_381 3461-2219 42.7 µM -0.877068272203277 0.160606089346861 no 2833 0.19022477831039 3933 2883159
SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM -0.878669267039986 0.160147567450414 no 2834 0.189790313417785 3920 6312947
SGTC_1759 st043059 70 µM -0.879785894588473 0.159828274527671 no 2835 0.189487653682114 3967 669426
SGTC_2072 5231554 129 µM -0.879843262928462 0.159811881651164 no 2836 0.189472112130238 3997 789545
SGTC_2868 9035608 32.47 µM -0.88317569591709 0.15886153401906 no 2837 0.188570675428416 3913 6462614
SGTC_3008 9078912 71.4286 µM -0.885774734471655 0.158122913012875 no 2838 0.187869463565244 3926 16648731
SGTC_952 1185-0122 232 µM -0.88785371212918 0.15753371341377 no 2839 0.187309723091776 3884 678600
SGTC_1519 esterone 74 µM -0.887857940820118 0.157532516439627 no 2840 0.187308585617842 3934 698 A steroid.
SGTC_295 k015-0027 31 µM -0.892428466655699 0.156242276471871 no 2841 0.186081659334367 3978 3887424
SGTC_2355 9061122 103.12 µM -0.892937622177116 0.156098976220118 no 2842 0.185945289104068 3986 5302957
SGTC_470 aa-861 153 µM -0.894198721965974 0.155744416603978 no 2843 0.185607787966153 3955 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor.
SGTC_3240 9133527 49.47 µM -0.895179998802051 0.155468897186568 no 2844 0.185345437425592 3907 17617455
SGTC_785 1270-0111 65.3 µM -0.896069035667184 0.155219554404203 no 2845 0.185107946711277 3911 6741994
SGTC_1902 st060212 70.5 µM -0.896365795697461 0.155136382711944 no 2846 0.18502871453588 3962 688944
SGTC_65 0798-0905 34.986 µM -0.899880828326752 0.154153477738776 no 2847 0.184091836871713 4054 3602145
SGTC_1719 st032227 49.2 µM -0.900577603869433 0.153959129380317 no 2848 0.183906473426299 3970 3125804
SGTC_3308 9128332 17.569 µM -0.90097586759246 0.153848116387211 no 2849 0.183800575411307 3995 17332805 YDL196W YDL196W
SGTC_157 1348-1695 65.819 µM -0.901417508624097 0.153725074261883 no 2850 0.183683187828162 3930 5380510
SGTC_2773 thioridazine 9.09 µM -0.90344871948718 0.153160013636855 no 2851 0.183143896430814 4003 5452 An antipsychotic.
SGTC_2850 9015429 58.44 µM -0.903848264152024 0.153049026904691 no 2852 0.183037932715408 4031 6457570
SGTC_543 3844-1095 191 µM -0.905215908331838 0.152669522211791 no 2853 0.182675507820279 3978 4230703
SGTC_3004 9076122 71.4286 µM -0.906668677400662 0.152267080698461 no 2854 0.182291016025433 4010 44782551
SGTC_1581 himbacine 57.9 µM -0.906901934655453 0.152202530185224 no 2855 0.182229329000678 3968 5281825 An alkaloid muscarinic receptor antagonist.
SGTC_2817 7995342 71.43 µM -0.90942588096539 0.151505227229655 no 2856 0.18156268276083 3990 18879975
SGTC_997 3996-0078 137 µM -0.909984535518953 0.151351172555914 no 2857 0.18141533271922 4020 735687
SGTC_1019 4262-0212 3.4 µM -0.91007618214261 0.151325910018011 no 2858 0.181391167268091 4003 4677213
SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM -0.911888959999354 0.150826791273741 no 2859 0.180913586880676 3987 364106
SGTC_2171 5739187 198.077 µM -0.915915442273763 0.149722089897104 no 2860 0.179855623364718 3924 2262761
SGTC_2626 ethyl orsellinate 100 µM -0.91611429839429 0.149667672177636 no 2861 0.179803474552966 3986 75653 A natural product.
SGTC_3335 9143315 29.6265 µM -0.916618491293381 0.149529757062059 no 2862 0.179671295599643 4002 4899691
SGTC_2712 st079126 47.7 µM -0.919031390646115 0.14887091570536 no 2863 0.179039576728049 3995 3152970
SGTC_2873 9040596 71.43 µM -0.919651547505179 0.148701895908521 no 2864 0.178877440071194 3996 6463863
SGTC_1984 st072354 53.1 µM -0.920522422643919 0.148464761061589 no 2865 0.178649910538375 3867 5762938
SGTC_2892 9047358 58.44 µM -0.921053409108498 0.148320300331149 no 2866 0.178511271625714 3988 6466771
SGTC_906 1165-0455 526 µM -0.921197442649568 0.14828113063339 no 2867 0.178473676604086 3970 3252859
SGTC_1608 st001473 40.5 µM -0.92332854152028 0.14770239027315 no 2868 0.17791800918251 3980 7292267
SGTC_1006 4099-6547 255 µM -0.923988012770586 0.147523605239319 no 2869 0.177746278485335 4042 3146833
SGTC_3258 9138477 49.47 µM -0.924941698866889 0.14726531403085 no 2870 0.177498117317783 4029 4970355
SGTC_3031 9088762 49.47 µM -0.92810047899323 0.146411972747018 no 2871 0.176677725592533 3986 205253
SGTC_2204 7233102 200 µM -0.928489745193871 0.146307043092757 no 2872 0.176576792384816 3896 2172480
SGTC_3056 9094900 49.47 µM -0.928959363150663 0.146180521236567 no 2873 0.176455073237095 3989 25236784
SGTC_2556 citropten 84.59 µM -0.930839946145171 0.145674601556809 no 2874 0.175968181460267 4040 2775 A potential DNA crosslinker.
SGTC_2789 5281112 71.43 µM -0.93169442678899 0.145445116196904 no 2875 0.175747233759211 4042 765948
SGTC_1364 1653-0028 37.6 µM -0.932654000089874 0.145187696406608 no 2876 0.17549932127762 4000 5718652
SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM -0.933360724061768 0.144998303368183 no 2877 0.175316876002943 4051 6708760
SGTC_2658 polymyxin b sulfate 77.05 µM -0.934113195920726 0.144796833361144 no 2878 0.175122752861435 4037 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides. YIL048W NEO1
SGTC_3119 9125183 49.47 µM -0.934131351906442 0.144791974530793 no 2879 0.17511807065456 3818 22695334
SGTC_2730 imipramine 71.33 µM -0.935586874574941 0.144402810737626 no 2880 0.174742967520506 3993 3696 A tricyclic antidepressant.
SGTC_3035 9091303 49.47 µM -0.936073592672678 0.144272834099457 no 2881 0.174617649151267 4072 25237002
SGTC_2735 sertaconazole 140 nM -0.937018399977982 0.14402075127132 no 2882 0.174374546628786 4126 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C
SGTC_1485 3909-9022 254 µM -0.93976556791899 0.143289471244987 no 2883 0.1736689120626 4045 714516
SGTC_3213 9129884 49.47 µM -0.939911831908006 0.14325060706163 no 2884 0.173631393860345 4025 17190742
SGTC_1513 0337-0559 19 µM -0.943057107160679 0.142416590333858 no 2885 0.172825846817618 4002 775073
SGTC_2752 diclazuril 33.15 µM -0.944481896354962 0.142039869295097 no 2886 0.172461724383245 3994 456389 An antifungal agent for coccidioides. YHR062C RPP1
SGTC_1328 1441-0025 69.2 µM -0.944579255560942 0.142014151702792 no 2887 0.172436860910822 3994 4562601
SGTC_2778 tioconazole 65.09 nM -0.945818196615099 0.141687158695911 no 2888 0.172120661377387 3925 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_2128 5255449 168.493 µM -0.947680627658167 0.141196568579955 no 2889 0.171646032991266 4018 736008
SGTC_393 acivicin 6.25 µM -0.947975136330958 0.141119096504376 no 2890 0.171571056015895 3873 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1
SGTC_2792 7535235 81.82 µM -0.952714206428317 0.139876422242812 no 2891 0.170367446690782 4040 1281891
SGTC_1165 k072-0275 30.3 µM -0.952834931057206 0.139844863399343 no 2892 0.170336856361115 4007 6153523 YGL055W OLE1
SGTC_2729 fluphenazine 10.66 µM -0.954763898481231 0.139341264983913 no 2893 0.16984855394637 3973 3372 An atypical antipsychotic.
SGTC_394 menadione 8.33 µM -0.957495530823541 0.138630226734007 no 2894 0.16915860054465 4025 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_2961 9083290 32.55 µM -0.959127458479956 0.138206620810627 no 2895 0.168747269560883 3970 17741490
SGTC_2943 9068529 45.32 µM -0.960842572157107 0.137762374017621 no 2896 0.168315664705167 4030 3270634
SGTC_2118 5526350 200 µM -0.961164544069532 0.137679085969117 no 2897 0.168234720356879 4086 743594
SGTC_1594 piperine 70.1 µM -0.965162250812647 0.136647816887437 no 2898 0.167231775593511 4022 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_2120 5538279 151.968 µM -0.966928753334299 0.136193807676144 no 2899 0.166789825751352 4023 2058197
SGTC_949 1165-0505 146 µM -0.969452619907421 0.135546940985772 no 2900 0.166159704535906 4077 6244267
SGTC_2786 7743617 45.45 µM -0.970326126071371 0.135323552621324 no 2901 0.165941979284526 4002 583674
SGTC_2904 7225135 42.03 µM -0.975267626937932 0.134064577831985 no 2902 0.164713762148549 4165 4446116
SGTC_1193 1488-0126 41.5 µM -0.979513129796262 0.132989372558342 no 2903 0.163663252181598 4032 1384710
SGTC_913 3487-1245 167 µM -0.981178874551319 0.132569136184423 no 2904 0.163252269973998 3996 4016153
SGTC_310 1273-0058 1.06 µM -0.981809798316564 0.132410205008077 no 2905 0.163096780048858 3943 2734232
SGTC_544 k015-0020 52.4 µM -0.982498409379193 0.132236892185301 no 2906 0.162927183098738 4074 3008304
SGTC_2617 dihydrotanshinone i 20.83 µM -0.983030895096362 0.132102980976142 no 2907 0.162796116660003 4051 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12
SGTC_2034 5197015 53.07 µM -0.984413582709476 0.131755695022814 no 2908 0.162456101171006 4083 780676
SGTC_2384 9036245 200 µM -0.984663077807462 0.131693097155426 no 2909 0.162394797307173 4017 6462766
SGTC_1671 st016596 74.5 µM -0.984986675711781 0.131611937603631 no 2910 0.162315307948722 4125 2829167
SGTC_2449 5812982 45.77 µM -0.986484428360609 0.131236745366733 no 2911 0.161947726396672 4002 776185
SGTC_529 4076-0302 30.3 µM -0.986709770883969 0.131180360275642 no 2912 0.161892469336457 4028 5816522
SGTC_787 4152-0075 138 µM -0.986729531400616 0.131175416607366 no 2913 0.161887624374129 4082 9566539
SGTC_262 fenpropimorph 62.5 µM -0.987324047471317 0.131026741285601 no 2914 0.161741902727366 4040 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_1661 st013063 9.66 µM -0.993897322808759 0.129390668731123 no 2915 0.160136428942714 4135 721395
SGTC_1124 fisetin 1.16336 µM -0.995852055926449 0.128906882920335 no 2916 0.159661016564621 4111 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster.
SGTC_619 1652-1634 108 µM -0.999025199431407 0.128124221214123 no 2917 0.158891242095948 4060 5400454
SGTC_2471 5466956 24.79 µM -1.00203339877424 0.127385296682424 no 2918 0.158163731195931 4053 724419
SGTC_1956 st077085 54 µM -1.00428700074143 0.126833674573671 no 2919 0.157620148763635 4137 24208685
SGTC_2510 benzyl isothiocyanate 8.31 µM -1.005680296885 0.126493465652701 no 2920 0.157284692043941 4087 2346 DNA damaging agent; causes G2/M arrest.
SGTC_583 1488-1091 88.9 µM -1.00583052700556 0.126456821126721 no 2921 0.157248549967172 4211 4303273
SGTC_244 nsc-207895 1.295 µM -1.00711725930875 0.126143260942584 no 2922 0.156939214047769 3881 42640
SGTC_2053 5265679 138 µM -1.01007063348903 0.125425612254591 no 2923 0.156230725294968 4028 764595
SGTC_2505 galangin 7.89 µM -1.01280766821428 0.124763081209951 no 2924 0.155576018632121 3993 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_1578 josamycin 24.2 µM -1.01307220045049 0.124699177959467 no 2925 0.155512837802176 4114 5282165 A P450 substrate.
SGTC_1747 st037496 66.6 µM -1.01403387640431 0.12446705793881 no 2926 0.155283293939371 4086 723305
SGTC_1470 k295-0292 231 µM -1.01449327572856 0.124356279279044 no 2927 0.155173718200921 4180 5045612
SGTC_1361 1608-0041 5.61 µM -1.01544846962452 0.124126166455214 no 2928 0.154946049186284 4074 X1361
SGTC_1573 oleylamine 1.06 µM -1.01816119571901 0.123474276940857 no 2929 0.154300678544295 4100 5356789 An amine of the fatty acid oleic acid.
SGTC_1950 st077106 7.18 µM -1.01942302232969 0.123171868628119 no 2930 0.154001090474689 4065 13831864
SGTC_731 3966-0296 387 µM -1.02152328514467 0.122669673141938 no 2931 0.15350329140976 4105 660956
SGTC_691 1548-0686 185 µM -1.02414588921325 0.122044599097707 no 2932 0.152883186169422 4109 46495133
SGTC_2350 9023895 38.85 µM -1.02493970930489 0.121855840985427 no 2933 0.152695818216715 4137 2997209
SGTC_1579 chlormadinone acetate 49.4 µM -1.02623916972991 0.121547292262645 no 2934 0.152389431213018 4143 45114258 A steroidal progestin.
SGTC_2562 3',7'-dimethoxyflavone 64.92 µM -1.02702666579686 0.121360573717907 no 2935 0.152203953956046 4197 688664
SGTC_1522 st012842 45.6 µM -1.02833150732502 0.121051634561225 no 2936 0.151896957502265 3966 3491067 YOR116C RPO31
SGTC_2235 salicylic acid 500 µM -1.03001487878688 0.120653891138143 no 2937 0.151501510559034 4142 338 A COX inhibitor and kinase inhibitor.
SGTC_1869 3',7'-dimethoxyflavone 40.3 µM -1.03059674270363 0.120516623785912 no 2938 0.151364982106522 4150 688664
SGTC_1386 3228-0095 33.8 µM -1.03519514815795 0.119435683372109 no 2939 0.150288892095391 4136 870181
SGTC_2023 5144124 124 µM -1.03524341725297 0.119424373223682 no 2940 0.150277623569881 4112 2830192
SGTC_2359 9039622 200 µM -1.03827403599088 0.118715768022488 no 2941 0.149571246457483 4074 6463596
SGTC_1778 st046819 58.9 µM -1.03863679514025 0.11863114883353 no 2942 0.149486843220323 4178 671715
SGTC_2582 agaric acid 100 µM -1.03972880869133 0.118376677037441 no 2943 0.149232956143555 3860 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase.
SGTC_925 2064-1272 59.6 µM -1.04112959733416 0.118050816704934 no 2944 0.148907702381623 4113 6815817
SGTC_2133 5320837 200 µM -1.04118009064362 0.118039082490277 no 2945 0.148895987023937 4184 2841355
SGTC_2731 amoxapine 43.43 µM -1.04189248796301 0.117873615353589 no 2946 0.148730763650587 4248 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine.
SGTC_3179 9107801 49.47 µM -1.04282702683568 0.117656800782057 no 2947 0.148514205791048 4125 4818259
SGTC_2404 5161160 200 µM -1.04463473709293 0.117238210441692 no 2948 0.148095909222892 4095 2831543
SGTC_150 3970-0969 77.2 µM -1.04630457163133 0.116852484630738 no 2949 0.147710217694706 4220 6615640
SGTC_319 1348-1596 45.5 µM -1.04657145048688 0.116790920039634 no 2950 0.147648637516123 4239 5380505
SGTC_3156 9099931 49.47 µM -1.04722121173639 0.116641126887523 no 2951 0.147498782166736 4173 18111053
SGTC_177 1327-0068 8.361 µM -1.04923391873973 0.116177990855971 no 2952 0.14703523560721 4141 15389900 YOR207C | YLR033W RET1 | RSC58
SGTC_3143 9086658 49.47 µM -1.04967747935792 0.116076100618095 no 2953 0.146933210665569 4191 25236626
SGTC_1615 st002656 86.5 µM -1.05015680706676 0.11596606565241 no 2954 0.146823012199235 4142 1584458
SGTC_860 0443-0016 25.1 µM -1.05069776110754 0.115841972653416 no 2955 0.146698712316964 4168 5337942
SGTC_1627 st003713 25.6 µM -1.05162437264879 0.115629630300533 no 2956 0.146485960543213 4176 16195070 YER133W GLC7
SGTC_1440 4100-1550 40 µM -1.0526342390299 0.115398524310433 no 2957 0.146254329276794 4141 742806
SGTC_577 r071-0003 38.6 µM -1.05276509021705 0.115368603306052 no 2958 0.146224334181549 4142 4568517 YMR134W ERG29
SGTC_1907 st060210 83.7 µM -1.05281511355207 0.115357166208583 no 2959 0.146212868394472 4179 688793
SGTC_285 1486-1325 46 µM -1.05378830070811 0.115134821644224 no 2960 0.145989925504216 4194 22310230
SGTC_3094 9117742 49.47 µM -1.05585358630766 0.114663974670691 no 2961 0.145517555929688 4084 17149698
SGTC_1479 0549-0158 134 µM -1.05665401071861 0.114481861619012 no 2962 0.14533476052374 4198 5440202
SGTC_1667 st014849 34.6 µM -1.05726810701743 0.114342281696467 no 2963 0.145194622211011 4192 5348460
SGTC_2969 9091408 28.7 µM -1.06063969015039 0.113578102489955 no 2964 0.144426838912408 4101 4286311
SGTC_2031 5180455 200 µM -1.06316468840797 0.11300819376025 no 2965 0.143853636432401 4110 29949
SGTC_2234 tolnaftate 200 µM -1.06371468777893 0.112884326450767 no 2966 0.143728984337279 4194 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7
SGTC_3351 9150312 21.596 µM -1.06414633413246 0.112787181746943 no 2967 0.143631206882314 4081 4904905
SGTC_2212 7123476 200 µM -1.06478814803855 0.112642847905327 no 2968 0.143485904842201 4121 1085715
SGTC_1504 k297-0033 30 µM -1.06494830631648 0.112606851404744 no 2969 0.143449661639224 4034 4388117
SGTC_396 dithiazanine 1.25 µM -1.06545943427603 0.112492027385375 no 2970 0.143334036685621 4149 10578 An antihelmenthic.
SGTC_1933 st074711 15.9 µM -1.06625584185125 0.112313282522682 no 2971 0.143154002581183 4145 17250958
SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM -1.06857856938545 0.111793131418437 no 2972 0.142629804731856 4119 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1
SGTC_708 3448-5400 146 µM -1.07195720374706 0.111039600230153 no 2973 0.141869627403168 4111 3462195
SGTC_1247 0448-0043 5.84 µM -1.07220975490607 0.110983420636762 no 2974 0.141812914950407 4202 3089013 YGL099W LSG1
SGTC_2600 tangeritin 87.95 µM -1.07345536891834 0.110706633657455 no 2975 0.141533426633017 4103 68077 A bioactive flavone.
SGTC_1399 3562-5772 25 µM -1.07454620702992 0.11046464590973 no 2976 0.141288973350382 4117 23847490
SGTC_678 1218-2179 85.9 µM -1.07536547760978 0.110283151284539 no 2977 0.141105565778103 4178 6820081 YOR116C RPO31
SGTC_2758 dehydroepiandrosterone 69.35 µM -1.07612408775345 0.110115285664535 no 2978 0.140935882088826 4180 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem]
SGTC_3247 9135149 49.47 µM -1.07957729533493 0.10935347443466 no 2979 0.140165228244972 4193 8934436 YOR116C RPO31
SGTC_1839 st053978 48 µM -1.07980547057688 0.109303270429857 no 2980 0.140114407295298 4184 3788398
SGTC_2680 butyl paraben 22.24 µM -1.0817730059435 0.108871052506713 no 2981 0.139676702035651 4254 7184 An antifungal and steroid mimetic.
SGTC_1533 dihydroergotamine mesylate 29.4 µM -1.08198876266452 0.108823731058763 no 2982 0.13962876061682 4266 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release.
SGTC_2781 5567276 71.43 µM -1.08356348471338 0.108478798551555 no 2983 0.139279194235331 4220 2853274
SGTC_1537 2',6'-dihydroxyflavanone 78 µM -1.08358100979672 0.108474964228029 no 2984 0.139275307264111 4175 5106787 A p450 inhibitor.
SGTC_2695 st077686 51.995 µM -1.08581362662893 0.107987285817248 no 2985 0.138780728206937 4199 2876092
SGTC_2517 totarol 10 µM -1.08583223043161 0.107983228765924 no 2986 0.138776612042549 4193 460178 An antibacterial membrane disruptor. YGL001C ERG26
SGTC_1258 0671-0043 57.1 µM -1.08638336712393 0.107863088614728 no 2987 0.138654708602955 4206 4298767
SGTC_2140 5586273 200 µM -1.08943564655685 0.107199476783271 no 2988 0.137980909542865 4151 854421
SGTC_1171 0368-0077 21.4 µM -1.09189021954638 0.106667954951396 no 2989 0.137440678563485 4135 3239779
SGTC_2388 9080168 200 µM -1.09711950067319 0.105541936474985 no 2990 0.136294578345519 4182 15943073
SGTC_510 ag-490 170 µM -1.09933638908247 0.105067178565549 no 2991 0.135810682797386 4313 5328779
SGTC_1567 st069303 68.4 µM -1.10149581674087 0.104606214156128 no 2992 0.135340462077802 4247 5581319
SGTC_2614 arthonioic acid 13.39 µM -1.10415057616386 0.104041523051512 no 2993 0.134763912493196 4062 6710684
SGTC_1478 0453-0656 35.7 µM -1.10941993441225 0.102927237544997 no 2994 0.133624533345182 4194 5258496
SGTC_2931 9014674 55.67 µM -1.10966890632588 0.10287480400389 no 2995 0.133570863186091 4165 2996810
SGTC_3057 9095946 49.47 µM -1.10976366786916 0.10285485230142 no 2996 0.133550439608183 4251 24540043
SGTC_1534 6-azauridine 81.6 µM -1.11034427222281 0.10273266952437 no 2997 0.13342535115507 4233 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1
SGTC_1910 st062352 60.4 µM -1.11232972405313 0.102315646838423 no 2998 0.132998204105112 4101 2245730
SGTC_2459 5811157 9.22 µM -1.11355992134354 0.102057875717595 no 2999 0.132734014188169 4178 2870684 YBR192W RIM2
SGTC_1617 st002906 78 µM -1.11680649329046 0.101379870391489 no 3000 0.13203853595519 4193 5150859
SGTC_1071 trifluoperazine 6.31 µM -1.11919823786298 0.100882488077475 no 3001 0.131527788522594 4281 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels.
SGTC_1903 st060211 78.3 µM -1.12446075561792 0.0997943745888347 no 3002 0.130408805085081 4244 688960
SGTC_3356 9151811 4.48 µM -1.12607566959958 0.0994621895310214 no 3003 0.130066745758117 4224 1859254 YPR165W RHO1
SGTC_710 3448-4187 58 µM -1.12824937979325 0.0990163381318637 no 3004 0.129607307486448 4191 3946412
SGTC_487 nimodipine 119 µM -1.12929618550083 0.098802149283552 no 3005 0.129386454755202 4186 4497 L-type voltage-gated calcium channels inhibitor
SGTC_62 0180-0423 3.232 µM -1.13251757776339 0.0981451416563037 no 3006 0.128708449306248 4187 30102 YGL099W LSG1
SGTC_1896 st058441 89 µM -1.13253452139607 0.0981416944600983 no 3007 0.12870488971418 4231 688759
SGTC_250 brefeldin a 552.239 µM -1.13351522465459 0.0979423206856359 no 3008 0.128498975690322 4100 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.
SGTC_2147 5545932 89.7195 µM -1.13663597782439 0.0973098570973321 no 3009 0.127845246668543 4252 797404
SGTC_2052 5265182 7.135 µM -1.1474783960557 0.0951357843237002 no 3010 0.125591978451146 4240 1239884
SGTC_1331 1472-0049 76.2 µM -1.150168968875 0.094601865273327 no 3011 0.125037142198207 4186 24051409
SGTC_3259 9138485 49.47 µM -1.15190943953081 0.0942576636660562 no 3012 0.124679144437822 4250 17646153
SGTC_926 2268-1401 59.4 µM -1.15250855401099 0.0941393946439673 no 3013 0.124556078365529 4215 2931578
SGTC_598 3937-0236 20.2 µM -1.15530215205699 0.0935893657518826 no 3014 0.123983357496247 4300 1379313
SGTC_3309 9129340 25.759 µM -1.16081651100829 0.0925106207589153 no 3015 0.122858263482493 4269 17158987
SGTC_2667 digitoxin 100 µM -1.16118205283729 0.0924394382031758 no 3016 0.122783935869967 4178 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_795 0685-0265 78 µM -1.16293857351386 0.0920979532719801 no 3017 0.122427212834664 4265 302754
SGTC_145 3737-0113 38.366 µM -1.1635847552129 0.0919725644563221 no 3018 0.122296166186174 4206 6849351
SGTC_2844 9010103 25.97 µM -1.16360064231946 0.0919694832237981 no 3019 0.122292945497037 4273 2480525
SGTC_346 4513-0042 7.16 µM -1.16578841190785 0.0915459049094646 no 3020 0.121850001777431 4219 2827372
SGTC_390 dec-rvkr-cmk 16.7 µM -1.16975352999369 0.090781898203276 no 3021 0.121050084674931 4299 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1
SGTC_3007 9078383 71.4286 µM -1.17130854927256 0.0904835691894026 no 3022 0.120737388113118 4238 6496995
SGTC_1944 st076371 56.9 µM -1.17344083301761 0.0900756767057669 no 3023 0.120309535320208 4230 24208455
SGTC_879 0831-1030 162 µM -1.1742416017205 0.089922848063084 no 3024 0.120149133503734 4269 1549252
SGTC_1401 3807-4679 7.6 µM -1.17425560400635 0.0899201774083226 no 3025 0.120146330049905 4195 3291456
SGTC_1460 k062-0059 9.15 µM -1.17817815975557 0.0891743477981504 no 3026 0.119362793795406 4151 1373085
SGTC_165 k038-0023 64.381 µM -1.17977781738062 0.0888715159756771 no 3027 0.119044297176078 4265 46368543
SGTC_1267 0828-0272 9.49 µM -1.1807474384014 0.0886883297267285 no 3028 0.118851535065355 4340 745334
SGTC_2933 9026794 32.47 µM -1.18087165150511 0.0886648830245884 no 3029 0.118826857253235 4211 17586027
SGTC_1150 3909-7983 10.9 µM -1.18093548865408 0.0886528347989076 no 3030 0.118814175932037 4248 23965914
SGTC_931 2812-0076 566 µM -1.18323681209466 0.0882193112836255 no 3031 0.1183576537153 4217 3450959
SGTC_2173 5763948 167 µM -1.18348121325727 0.0881733639514074 no 3032 0.118309243871583 4247 2867177
SGTC_2956 9076196 2.52 µM -1.18782747404722 0.0873592452603113 no 3033 0.117450693939398 4270 16423868
SGTC_1349 flufenamic acid 69 µM -1.18979425851737 0.0869926870965926 no 3034 0.117063633391614 4213 3371 A non-steroidal anti-inflammatory.
SGTC_764 1951-2361 146 µM -1.19530392752954 0.0859719445691079 no 3035 0.115984152918355 4285 5438930
SGTC_1164 k060-0068 93.7 µM -1.19670687316536 0.0857134667631771 no 3036 0.11571041356895 4287 5963676
SGTC_203 k066-0004 30.888 µM -1.19706728914045 0.0856471579767572 no 3037 0.115640164224438 4354 6795412
SGTC_2701 st077767 14.721 µM -1.20779354432323 0.0836912954628076 no 3038 0.113563342637415 4264 5721188
SGTC_1864 st057645 30.4 µM -1.20797268677196 0.0836589173006483 no 3039 0.113528884266708 4333 688666
SGTC_1675 st018485 24.5 µM -1.20937918839584 0.0834050334786798 no 3040 0.113258600194222 4326 3323024
SGTC_1458 k015-0034 6.33 µM -1.21000511051354 0.0832922363439655 no 3041 0.113138465943091 4318 3598957
SGTC_682 0kpi-0099 17 µM -1.21138982789068 0.0830431046171464 no 3042 0.112873018023683 4309 1714895 YML126C ERG13
SGTC_2903 5923464 63.88 µM -1.21237991982924 0.0828653159271794 no 3043 0.112683491909974 4301 2876576
SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM -1.21337194116471 0.0826874681333747 no 3044 0.11249382449529 4296 5379071
SGTC_2387 9077560 195.08 µM -1.21642207790845 0.0821424445333643 no 3045 0.111912088934239 4303 5303272
SGTC_3112 9123419 49.47 µM -1.21768333923888 0.0819178644835164 no 3046 0.111672165366208 4345 17015854
SGTC_2255 7941087 197.44 µM -1.21983493098186 0.0815358206943808 no 3047 0.111263728301329 4412 935561
SGTC_3278 9139605 49.47 µM -1.22302460880233 0.0809719253720364 no 3048 0.110660200849089 4297 7958859
SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM -1.225433849381 0.0805479567862069 no 3049 0.110205899905866 4309 521171
SGTC_2183 6420625 130.508 µM -1.22545704331962 0.0805438833740413 no 3050 0.110201532827698 4320 2897619
SGTC_441 propafenone 146 µM -1.22707355004996 0.0802603691896281 no 3051 0.109897474061254 4294 4932 Slows the influx of sodium ions into the cardiac muscle.
SGTC_2054 5233173 129 µM -1.22715302880266 0.0802464491313951 no 3052 0.109882539953937 4337 6889
SGTC_430 0958-0115 16.4 µM -1.22727945641932 0.080224310120614 no 3053 0.109858787126862 4253 6833180
SGTC_1733 st037357 54.9 µM -1.2286326351473 0.0799876411426692 no 3054 0.109604786890558 4213 1272339 YGL099W LSG1
SGTC_1319 1306-0155 43.7 µM -1.22964353095314 0.0798111817268687 no 3055 0.109415310689574 4352 3122360
SGTC_1439 4092-1168 46 µM -1.23046520050318 0.0796679702155719 no 3056 0.109261475333071 4311 2886240
SGTC_1484 3473-2379 286 µM -1.23214510965421 0.0793757784546163 no 3057 0.108947441625472 4434 671917
SGTC_2611 pyromycin 23.93 µM -1.23529309352164 0.0788304251945055 no 3058 0.108360721594937 4286 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release.
SGTC_21 0849-0113 22.993 µM -1.23637388199811 0.078643846672684 no 3059 0.10815980991418 4278 1560156
SGTC_1298 1079-1278 263 µM -1.23777487616885 0.0784024887907653 no 3060 0.107899773315304 4294 2840950
SGTC_2480 5767542 37.17 µM -1.2379704034421 0.0783688488132279 no 3061 0.107863517600948 4243 2867358
SGTC_681 1642-0006 26.6 µM -1.24307256406181 0.0774948988514943 no 3062 0.106920547424948 4333 4446530
SGTC_2009 4012297 12.05 µM -1.24618922368344 0.0769646988652064 no 3063 0.106347467191021 4303 45595307
SGTC_92 0063-0024 660.874 µM -1.24787179022854 0.0766796123849083 no 3064 0.106039006442573 4409 3594437
SGTC_2256 7954252 200 µM -1.24956722702048 0.0763931582417207 no 3065 0.105728840637629 4330 2972920
SGTC_1574 spiramycin 23.7 µM -1.24994391246903 0.0763296256758969 no 3066 0.105660018362204 4285 6419898 An antibiotic and protein synthesis inhibitor.
SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM -1.25017341228493 0.0762909374655272 no 3067 0.105618103504398 4328 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding.
SGTC_2528 xanthyletin 44.79 µM -1.25171357187524 0.0760316891961149 no 3068 0.105337126443399 4361 65188 An natural product with antifungal activity of unknown mechanism.
SGTC_361 000s-0510 1.45 µM -1.25201259192944 0.0759814343097919 no 3069 0.105282637842441 4247 660
SGTC_995 3931-2021 34.6 µM -1.25850055932759 0.0748972499092057 no 3070 0.104105392524539 4325 730143
SGTC_1326 1431-2094 10.8 µM -1.25886513788662 0.0748366783301153 no 3071 0.104039523896968 4319 616278
SGTC_2972 9093619 59.92 µM -1.26007467777434 0.0746359913767285 no 3072 0.103821212037979 4284 25236256
SGTC_3322 9139058 2.11 µM -1.26422427976653 0.0739506100417669 no 3073 0.103074769273643 4376 4908926 YPR165W RHO1
SGTC_1915 st067105 30.6 µM -1.26501345768127 0.0738208091291883 no 3074 0.102933251852069 4275 69751 YOR207C | YOR116C RET1 | RPO31
SGTC_3002 9075603 71.4286 µM -1.26582837707364 0.0736869571706145 no 3075 0.102787266594997 4277 20105405
SGTC_820 1582-0060 59.9 µM -1.27023245164175 0.0729667887633622 no 3076 0.102000920655796 4368 3848840
SGTC_2203 7227154 166.4 µM -1.27071816882327 0.0728876937228222 no 3077 0.101914464774642 4362 896304
SGTC_719 2810-4230 27.3 µM -1.27279014736564 0.0725510260959034 no 3078 0.101546259164541 4362 721079
SGTC_2442 5158906 48.48 µM -1.27385229351484 0.0723789046026356 no 3079 0.101357884130045 4352 1893835
SGTC_2420 aureobasidin a 50 nM -1.27449392622724 0.0722750792862912 no 3080 0.101244211919398 4432 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1
SGTC_1952 st077036 64.1 µM -1.27623481671457 0.0719939533371687 no 3081 0.100936262224454 4358 2937007
SGTC_347 4534-1311 26.2 µM -1.27828303240464 0.0716642736265581 no 3082 0.10057482416094 4349 2862016
SGTC_2552 juarezic acid 87.02 µM -1.27838848189606 0.0716473319328643 no 3083 0.100556241621554 4290 1549512
SGTC_2172 5754775 163.918 µM -1.27903472293118 0.0715435728630922 no 3084 0.100442414325781 4323 2263357
SGTC_2819 7996655 46.38 µM -1.28224508453456 0.071029832451806 no 3085 0.0998783426551902 4315 6456960
SGTC_629 3448-6466 76.7 µM -1.28330799918234 0.070860364549726 no 3086 0.0996920956550668 4360 573744
SGTC_654 1124-0271 80.9 µM -1.29200816717928 0.0694848914936346 no 3087 0.0981771581185262 4340 5403748
SGTC_1396 3511-0007 98.6 µM -1.29577456160481 0.0688958505274625 no 3088 0.0975265822834314 4387 X1396
SGTC_1120 ficusin 1.78878 µM -1.29859276685433 0.0684576239407765 no 3089 0.0970418607887053 4383 6199 A DNA cross-linker.
SGTC_1867 st057372 64 µM -1.30154526057242 0.068000825563532 no 3090 0.0965359413635998 4321 688837
SGTC_3233 9132340 49.47 µM -1.30747799006153 0.0670900563543369 no 3091 0.0955252126214034 4372 17682950
SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM -1.30854630620778 0.0669270596194858 no 3092 0.0953440395801522 4430 279621
SGTC_500 h-89 112 µM -1.31092501983705 0.0665652314900534 no 3093 0.0949415484697699 4348 449241 Protein kinase A inhibitor; also known to inhibit several other kinases.
SGTC_312 4092-0653 6.84 µM -1.31117220401602 0.0665277191114251 no 3094 0.0948997954841822 4266 1148278
SGTC_2963 9082507 9 µM -1.31193597589528 0.0664119133913473 no 3095 0.0947708688421652 4390 16459611
SGTC_61 0978-8327 98.565 µM -1.31639989474908 0.0657381979534028 no 3096 0.0940199288720477 4290 6150059 YHR072W ERG7
SGTC_2855 9016525 58.44 µM -1.31980610921286 0.0652276893069451 no 3097 0.0934498806900567 4326 43811474
SGTC_352 k048-0007 5.11 µM -1.3229555686252 0.0647584039275093 no 3098 0.0929250770276048 4321 6811911
SGTC_3095 9117207 49.47 µM -1.32430710088981 0.0645578245174232 no 3099 0.0927005365914491 4371 17015229
SGTC_1610 st001799 48.1 µM -1.32543504980461 0.0643907965961232 no 3100 0.0925134491766539 4336 621897
SGTC_2444 5485484 36.41 µM -1.32595958112422 0.0643132378921291 no 3101 0.092426542928631 4446 6790631
SGTC_1986 st071812 45 µM -1.32675274693012 0.0641960960401538 no 3102 0.0922952431052132 4323 11838594
SGTC_603 3794-0023 45.9 µM -1.33057810073319 0.0636334607489954 no 3103 0.0916639361082573 4414 3802260
SGTC_2040 5100729 123 µM -1.33076898885406 0.063605485637819 no 3104 0.0916325174185833 4413 11840 YJR013W | YDR381W GPI14 | YRA1
SGTC_1038 k292-0204 154 µM -1.33107471029361 0.0635607013666153 no 3105 0.0915822146888828 4335 4454212
SGTC_3289 9119912 71.43 µM -1.33145897222923 0.0635044467271039 no 3106 0.0915190181070793 4397 17014829
SGTC_3121 9125696 49.47 µM -1.33258165090704 0.0633403123568818 no 3107 0.0913345650057851 4498 1235365
SGTC_3116 9124943 49.47 µM -1.33746558125959 0.0626301276753475 no 3108 0.0905353549645759 4356 41905195 YPL160W CDC60
SGTC_2156 5649887 115 µM -1.33806558633263 0.0625433092014342 no 3109 0.090437528884367 4421 54680440 YKL052C | YBR257W ASK1 | POP4
SGTC_870 0573-2213 57.6 µM -1.33956959714015 0.0623260968434358 no 3110 0.0901926568023819 4391 3916321
SGTC_640 3381-0960 37.1 µM -1.34153076913797 0.0620437445924789 no 3111 0.0898740933335475 4452 1745025
SGTC_1705 st027868 56.3335 µM -1.34534620375777 0.0614972926001298 no 3112 0.0892567296228616 4334 292948
SGTC_2560 caryophyllene 100 µM -1.34546190418963 0.0614807807315718 no 3113 0.0892380579080888 4427 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor.
SGTC_2100 5377183 190 µM -1.3519542405028 0.0605597813958482 no 3114 0.0881949771251007 4424 2844202
SGTC_1443 4112-3303 14 µM -1.35213658939135 0.0605340701779607 no 3115 0.088165812109708 4439 704433
SGTC_560 2332-1943 155 µM -1.35706845238396 0.0598419107638994 no 3116 0.0873797306677274 4400 21177716
SGTC_1575 cyproterone acetate 48 µM -1.36399955029221 0.0588796669733518 no 3117 0.0862838536031367 4408 9880 An androgen receptor antagonist and liver toxin.
SGTC_1711 st032263 62.8 µM -1.36439414478123 0.0588252528674598 no 3118 0.0862217748630621 4393 3958979
SGTC_380 3970-0968 6 µM -1.36443521420936 0.0588195917108241 no 3119 0.0862153156224302 4293 2891601
SGTC_972 1319-0219 195 µM -1.36458155045814 0.0587994236754387 no 3120 0.0861923033662283 4401 23903702
SGTC_641 4092-0595 30 µM -1.37101695871297 0.0579178521527504 no 3121 0.0851848347632541 4468 786260
SGTC_1285 0929-0069 65.5 µM -1.37422735915859 0.0574819682102526 no 3122 0.0846855547892205 4461 1206237
SGTC_2666 tannic acid 100 µM -1.37918709119133 0.0568136509228281 no 3123 0.0839185385410956 4399 16134267 A thiamine antagonist.
SGTC_2267 7931562 200 µM -1.3867800385466 0.0558023850593606 no 3124 0.0827544228612603 4378 934880
SGTC_1017 4239-0030 168 µM -1.38791875912486 0.0556519570173001 no 3125 0.0825808924351063 4445 1149593
SGTC_1632 st005650 90 µM -1.39058538601139 0.0553009407454162 no 3126 0.0821755952063436 4446 2759605
SGTC_2151 5563267 85.4165 µM -1.39168549124617 0.0551566409564448 no 3127 0.0820088288561964 4485 5310824
SGTC_1325 1431-0015 227 µM -1.39204855226765 0.0551090839104075 no 3128 0.0819538479759897 4442 1103340
SGTC_3221 9128209 49.47 µM -1.39285190228376 0.0550039689381124 no 3129 0.0818322897737491 4454 16460723
SGTC_3210 9128157 49.47 µM -1.40055609299925 0.0540039348702097 no 3130 0.0806734292453594 4397 17590849
SGTC_3217 9129673 49.47 µM -1.4045688117601 0.0534887986454442 no 3131 0.080074768131377 4419 17248312
SGTC_3127 9126946 49.47 µM -1.40783740810063 0.0530720737063392 no 3132 0.0795896103178245 4397 27243249
SGTC_1614 st002383 48.6 µM -1.41345726943776 0.052361600228696 no 3133 0.0787606584592427 4475 1947235
SGTC_2423 st077119 87.2 µM -1.41419458576206 0.0522689503088423 no 3134 0.0786523886204878 4369 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae).
SGTC_2192 5915882 198.485 µM -1.41462911085975 0.052214409619159 no 3135 0.078588634441055 4414 2876149
SGTC_2607 solasodine 47.35 µM -1.41475584406832 0.0521985108459729 no 3136 0.0785700473330665 4404 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity.
SGTC_690 glyoxal 20.3 µM -1.4160783669658 0.0520328287017592 no 3137 0.0783762805617743 4243 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins.
SGTC_1304 1165-0502 251 µM -1.41666892046501 0.0519589807927971 no 3138 0.0782898739184242 4427 767425
SGTC_6 0844-0013 19.835 µM -1.41705847295381 0.0519103133871193 no 3139 0.0782329162278657 4567 1584900
SGTC_1092 toremifene 6.32 µM -1.41852462908411 0.0517274688374761 no 3140 0.0780188266546527 4440 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_2296 7971656 126.45 µM -1.42068419178296 0.0514590822429069 no 3141 0.0777042951172669 4452 666570
SGTC_278 4092-0821 23.9 µM -1.42080071510493 0.0514446324811665 no 3142 0.0776873513788712 4450 877900
SGTC_1148 3909-7663 27.7 µM -1.42217144441468 0.0512748939639091 no 3143 0.0774882431721559 4489 4084526
SGTC_667 1498-1044 59 µM -1.42731434494464 0.0506420129420919 no 3144 0.0767446538109832 4451 6739982
SGTC_2467 5474540 200 µM -1.43008094948822 0.0503041396102654 no 3145 0.076346893589159 4433 5413519
SGTC_2239 6685329 187.64 µM -1.43029592255454 0.0502779612908301 no 3146 0.0763160522881103 4478 805680
SGTC_3135 9127742 49.47 µM -1.43757101108198 0.0493984219742763 no 3147 0.0752779055052966 4518 3643468
SGTC_1965 Pectolinarigenin 58.4 µM -1.43779042445347 0.0493720875078503 no 3148 0.0752467635474287 4438 5320438 An anti-inflammatory.
SGTC_675 1309-0189 238 µM -1.44837619575243 0.0481148197930966 no 3149 0.0737559342059093 4477 4246530
SGTC_1402 3909-7673 35.9 µM -1.45085705662174 0.0478239062135462 no 3150 0.0734098339564443 4490 5328014
SGTC_947 3447-0010 211 µM -1.45203669379298 0.0476860731157681 no 3151 0.0732457013456702 4423 748350
SGTC_1307 1187-1599 12.2 µM -1.45245707611599 0.0476370310720392 no 3152 0.0731872780004064 4470 1538471
SGTC_3274 9138298 49.47 µM -1.45366050819732 0.0474968613093713 no 3153 0.0730202261194687 4448 17015756
SGTC_2136 5328288 199.296 µM -1.45448244399178 0.047401316376531 no 3154 0.0729062986683135 4439 262395
SGTC_2250 alverine citrate 130 µM -1.45516914475339 0.0473216098107803 no 3155 0.0728112203393328 4343 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1
SGTC_672 1441-0018 53.7 µM -1.4558546069101 0.0472421541670174 no 3156 0.0727164082078365 4468 251141
SGTC_3220 9131269 49.47 µM -1.4568226055555 0.04713013034807 no 3157 0.0725826770994005 4474 17722206
SGTC_1804 st050076 49.1 µM -1.45763164111434 0.0470366663484927 no 3158 0.0724710516658598 4493 3895976
SGTC_2117 5521686 200 µM -1.457827823408 0.0470140247514879 no 3159 0.0724440035383627 4448 803312
SGTC_1805 st050013 60.3 µM -1.45791554371904 0.0470039036894652 no 3160 0.0724319118293313 4413 4037144
SGTC_2400 5203494 178.7 µM -1.46402525993837 0.0463032599996028 no 3161 0.0715935233438608 4384 6777674
SGTC_2502 avocadyne acetate 18.59 µM -1.4649401876113 0.0461990644969802 no 3162 0.0714686185623921 4414 3952079
SGTC_2233 sulbentine 40.3845 µM -1.46661990311464 0.0460082622322066 no 3163 0.0712397413324672 4476 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58
SGTC_317 4495-0002 170 µM -1.46866316120416 0.0457770184046379 no 3164 0.0709620870505379 4489 15991618
SGTC_652 0437-0092 114 µM -1.47854630463386 0.0446716581227471 no 3165 0.0696308063625032 4435 3091274
SGTC_2578 7,8-dihydroxyflavone 64.44 µM -1.48017375610259 0.0444917176302581 no 3166 0.0694134411159716 4358 1880 Intensifies effect of antibiotics on Staphylococcus aureus.
SGTC_13 0199-0087 65 µM -1.48400420578234 0.0440705051119036 no 3167 0.0689039024143668 4594 4589825
SGTC_914 3820-6779 408 µM -1.48708686161241 0.0437338632696996 no 3168 0.0684959355463747 4419 2893481
SGTC_3011 9081274 71.4286 µM -1.50059784951876 0.0422827922014361 no 3169 0.0667298039503792 4495 6625322
SGTC_3123 9126162 49.47 µM -1.50228461694252 0.0421044016798624 no 3170 0.0665118098638714 4499 25239884
SGTC_729 4092-0585 94.1 µM -1.50473890646743 0.0418459273716603 no 3171 0.0661956080777407 4504 2169061
SGTC_707 0865-0008 204 µM -1.51001305873934 0.0412948250864188 no 3172 0.0655200460328472 4542 723043
SGTC_2801 7907800 81.82 µM -1.51364256521119 0.040919002269117 no 3173 0.0650582596239506 4482 6620925
SGTC_2413 inermin 26.06 µM -1.51639589572908 0.0406357590703708 no 3174 0.0647096381272908 4525 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1
SGTC_1949 st076024 69.1 µM -1.51889219806118 0.0403803344810419 no 3175 0.064394816590804 4468 2921930
SGTC_837 0091-0265 12.5 µM -1.51940485752094 0.040328040266286 no 3176 0.0643303100155854 4498 759367
SGTC_1695 st026914 34.495 µM -1.52013242733107 0.0402539183881709 no 3177 0.0642388480612859 4493 3289191
SGTC_167 3672-0051 66.205 µM -1.52121635244558 0.0401436977268794 no 3178 0.0641027765823499 4420 3237971
SGTC_438 sphingosine 6.67 µM -1.52213715131778 0.0400502575430769 no 3179 0.0639873594184176 4437 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes.
SGTC_1731 st035964 63 µM -1.52254013011263 0.0400094199757546 no 3180 0.0639368990648783 4422 6739575
SGTC_1616 st002734 56.1 µM -1.52296288472582 0.0399666147177006 no 3181 0.0638839956812265 4472 4026101
SGTC_2694 st077685 81.9 µM -1.53521502370159 0.0387421309757315 no 3182 0.0623655095786707 4431 2838096
SGTC_817 1391-0715 46 µM -1.53651041795006 0.0386144746215373 no 3183 0.0622066223368076 4501 1353946
SGTC_1025 k007-0731 70 µM -1.54793953886273 0.0375029670705963 no 3184 0.0608184269905486 4504 6256118
SGTC_792 4534-1957 155 µM -1.55309846650866 0.0370098795505404 no 3185 0.0601998062107518 4490 1717904
SGTC_2150 5556613 200 µM -1.55513109021314 0.0368170634903879 no 3186 0.0599574258960176 4555 743190
SGTC_3130 9127414 49.47 µM -1.5553355173776 0.0367977169367671 no 3187 0.059933091327732 4555 1494646
SGTC_1344 1488-0097 29.1 µM -1.5569360678531 0.0366465314218286 no 3188 0.0597428325350287 4549 747966
SGTC_2416 tofa 880 nM -1.55913816492504 0.0364393555764366 no 3189 0.0594818411688391 4473 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_767 0929-0023 86 µM -1.56727760518004 0.035681891022657 no 3190 0.0585249088203329 4563 1204563
SGTC_1737 st035557 69.7 µM -1.56742273157309 0.0356685034124431 no 3191 0.0585079570337424 4381 5716916
SGTC_677 0929-0063 136 µM -1.56977603965736 0.0354519896506142 no 3192 0.0582336118521839 4562 1539583
SGTC_1684 st024538 14.6195 µM -1.57220808216505 0.0352293655539541 no 3193 0.0579511508424861 4512 6732859
SGTC_1576 erythromycin ethylsuccinate 23.2 µM -1.57500101500549 0.0349751223706724 no 3194 0.0576281051329126 4531 3256 An antibiotic and ribosome inhibitor.
SGTC_2417 cerulenin 830 nM -1.57675287511535 0.0348164189134822 no 3195 0.0574261993826133 4535 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1
SGTC_2710 st078562 53.7235 µM -1.57919448811146 0.0345962164999656 no 3196 0.0571457269247155 4506 17250908
SGTC_3122 9126309 49.47 µM -1.58364362949579 0.0341979024677358 no 3197 0.0566374197222166 4640 17591206
SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM -1.58933476347604 0.0336939008966739 no 3198 0.055992417134019 4456 5355888
SGTC_1613 st002381 52.1 µM -1.59120769830948 0.0335293783737411 no 3199 0.055781420473675 4549 551167
SGTC_1826 st055655 41.6 µM -1.60207824616101 0.0325874961715794 no 3200 0.0545691539049539 4542 676168
SGTC_3118 9124250 49.47 µM -1.60725720742373 0.0321464987083187 no 3201 0.053998978662246 4513 1504786
SGTC_1461 k072-0203 53.8 µM -1.60767616009881 0.0321110405954674 no 3202 0.0539530612280513 4434 5418714
SGTC_1400 3771-8998 51.5 µM -1.60796565270485 0.0320865582212898 no 3203 0.0539213507490208 4512 670767
SGTC_313 3474-0040 5.03 µM -1.60812975154158 0.0320726872366862 no 3204 0.053903382223023 4570 1043375 YIL048W NEO1
SGTC_966 1300-0360 30.2 µM -1.61055431187258 0.0318683197833146 no 3205 0.0536384493594556 4541 70588
SGTC_3337 9144342 33.5465 µM -1.61328279614828 0.0316396219969744 no 3206 0.0533415412266458 4557 17682949
SGTC_2753 fluvastatin 17.09 µM -1.61759512803129 0.0312809352390186 no 3207 0.0528749398682612 4534 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5
SGTC_2383 9036125 200 µM -1.62492162840157 0.0306792522984511 no 3208 0.0520896295212763 4520 79580
SGTC_66 0109-0187 42.4 µM -1.62703363573951 0.0305075956659399 no 3209 0.0518649771341288 4420 759417
SGTC_1721 st082152 9.2685 µM -1.64206905395298 0.0293084279568746 no 3210 0.0502878470452746 4505 5296051
SGTC_1898 st060199 18.6 µM -1.65028147923943 0.0286701379349455 no 3211 0.049442689264375 4562 688866
SGTC_2352 9027995 87.8 µM -1.65330248424206 0.0284382652418917 no 3212 0.0491346588315635 4536 2997347
SGTC_901 1112-0062 60.1 µM -1.66824436132311 0.0273142508233547 no 3213 0.0476336139488933 4565 1908457
SGTC_3283 9109332 35.8195 µM -1.66835325833999 0.027306196987823 no 3214 0.0476228106272692 4407 17027281
SGTC_20 0481-0013 4.944 µM -1.67870028798741 0.0265499335169437 no 3215 0.0466052349033817 4631 182045
SGTC_1459 k035-0031 35.7 µM -1.68560141361422 0.0260553220795245 no 3216 0.0459362983840908 4335 3877128 YMR208W ERG12
SGTC_3041 9091929 49.47 µM -1.68993092911448 0.0257489726849656 no 3217 0.0455205848067996 4558 25236887
SGTC_880 0833-0487 87.2 µM -1.69827818870488 0.0251668406855268 no 3218 0.0447276346714239 4582 76075
SGTC_2122 5258151 111.688 µM -1.70655410644982 0.0246006131454719 no 3219 0.0439524807530865 4605 2173356
SGTC_2160 5660466 132.927 µM -1.70724484477827 0.0245538409464259 no 3220 0.0438882764867932 4545 2859134
SGTC_2148 5546263 113.568 µM -1.71445138937245 0.0240702975430253 no 3221 0.0432229287207788 4624 792097
SGTC_413 propylparaben 100 µM -1.71548818640326 0.0240013934579391 no 3222 0.0431278797416184 4575 7175 A pharmaceutical preservative.
SGTC_523 1934-0222 13.7 µM -1.71682235903621 0.0239129701450935 no 3223 0.0430058171719822 4568 1361595
SGTC_1340 1486-1359 257 µM -1.71805619385065 0.023831440632608 no 3224 0.0428931830068602 4567 4309068
SGTC_655 k060-0012 42 µM -1.71862465949224 0.0237939561811965 no 3225 0.0428413692621207 4594 5994525
SGTC_755 1995-0008 37.3 µM -1.71943455365711 0.0237406376293963 no 3226 0.0427676374975518 4579 689533
SGTC_408 cantharidin 100 µM -1.72078783737584 0.0236517697621121 no 3227 0.0426446651324685 4591 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_432 NS 1619 61.3 µM -1.72892649834096 0.0231231982595988 no 3228 0.0419111254193535 4553 4552 A K+/calcium channel activator.
SGTC_900 1112-0045 141 µM -1.73078168086592 0.023004114099221 no 3229 0.0417453552125014 4519 56211 YIL048W NEO1
SGTC_673 1082-0474 110 µM -1.73800793573706 0.0225451738199873 no 3230 0.0411047077385676 4581 3098046
SGTC_1850 st056238 17 µM -1.7380204652852 0.0225443848209281 no 3231 0.0411036038881002 4609 5393177
SGTC_2369 9071472 200 µM -1.74482336564014 0.0221194230449062 no 3232 0.0405078101290271 4611 17296037
SGTC_2431 5490079 200 µM -1.74547946883568 0.022078797594941 no 3233 0.0404507216198665 4622 5722345
SGTC_309 k408-0051 1.48 µM -1.74778480773613 0.0219365517024048 no 3234 0.0402506484836707 4529 3640463
SGTC_2248 tofa 1.1 µM -1.75510809166842 0.0214898077005324 no 3235 0.0396204102573931 4640 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_1963 st076565 50.3 µM -1.75933880048035 0.0212352430463873 no 3236 0.039259990000809 4634 4914280
SGTC_2304 7443016 91.4 µM -1.75974706525028 0.0212108129696634 no 3237 0.0392253509485047 4566 939854
SGTC_2399 5884133 200 µM -1.7707931400724 0.0205587957739871 no 3238 0.0382975535561272 4550 722445
SGTC_2673 kobusone 100 µM -1.7823731505129 0.0198935730979401 no 3239 0.0373442004734233 4717 6710676 An epoxy ketone and protein crosslinker.
SGTC_838 0109-0203 71.4 µM -1.78576884314281 0.0197020027912479 no 3240 0.0370683467083561 4648 759422
SGTC_709 3807-1509 243 µM -1.78769740770271 0.0195939004930222 no 3241 0.0369124201011922 4676 1886677 YPL242C IQG1
SGTC_1612 st002233 45.4 µM -1.79146517714592 0.019384157625313 no 3242 0.0366093389442735 4637 1035021
SGTC_2168 5727979 200 µM -1.79311499357865 0.0192929185069768 no 3243 0.0364772693318445 4547 695210
SGTC_455 paf C-16 10 µM -1.79772852287235 0.0190397134653482 no 3244 0.0361100195539156 4595 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis.
SGTC_2382 9035899 200 µM -1.807936665041 0.018489487152969 no 3245 0.0353081792316013 4619 6462679
SGTC_268 camptothecin 39.6153 µM -1.81020460687231 0.0183690989431317 no 3246 0.0351320317358909 4581 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_2760 etidronate 98.04 µM -1.81201425703628 0.0182735176006631 no 3247 0.034991996802365 4589 3305 A chelator and antioxidant.
SGTC_706 4262-0057 46.9 µM -1.8172387180681 0.0179999485723977 no 3248 0.0345902844265491 4631 883298
SGTC_2575 plumbagin 510 nM -1.81842033815567 0.0179385617968501 no 3249 0.0344999560882041 4561 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_1886 st057356 49.9 µM -1.8481399870279 0.0164522726977809 no 3250 0.0322910472041566 4633 24207747
SGTC_970 1315-0089 19.5 µM -1.84986087480264 0.016369538546688 no 3251 0.0321668021258163 4621 6811083 YLR033W RSC58
SGTC_2238 6671620 73.2395 µM -1.84993486577533 0.0163659893271332 no 3252 0.0321614689681408 4558 729941
SGTC_2668 2',4'-dihydroxychalcone 15.08 µM -1.87283363797735 0.0152987662756607 no 3253 0.030545680680311 4697 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_2146 5545642 200 µM -1.87290680210582 0.015295454533078 no 3254 0.0305406278664442 4621 825326
SGTC_1136 pergolide 1.05886 µM -1.87563973903361 0.0151721895955441 no 3255 0.0303523828844812 4596 47811 A dopamine receptor agonist.
SGTC_2865 9030313 51.95 µM -1.8891967888635 0.0145732605550003 no 3256 0.0294327324289388 4630 42562754
SGTC_2900 5328528 85.29 µM -1.89626777023551 0.0142690297665226 no 3257 0.0289623228955813 4634 795359
SGTC_3196 9111891 49.47 µM -1.90745521554805 0.0137988627409249 no 3258 0.0282308325517769 4629 18891510
SGTC_1195 1502-0147 41.1 µM -1.93250574886619 0.012794301034378 no 3259 0.0266485565877586 4676 817940
SGTC_1964 st076914 61 µM -1.95022257875781 0.0121226035967478 no 3260 0.0255747978842722 4689 24208661
SGTC_840 0245-0196 390 µM -1.9541970906556 0.0119761869518728 no 3261 0.0253389566307219 4720 3827528
SGTC_2145 5634607 200 µM -1.97240214434444 0.0113249678713402 no 3262 0.0242818586265226 4679 308662
SGTC_2176 5809774 33.9695 µM -1.97382421282078 0.0112754195107861 no 3263 0.0242008673325574 4624 2870539
SGTC_19 0279-0214 38.434 µM -1.99637590262017 0.0105144832158805 no 3264 0.0229465108759636 4730 3566274 YBR002C RER2
SGTC_1722 st034304 3.6505 µM -2.00232540895445 0.0103213524716315 no 3265 0.0226248724894602 4619 4036148 YLR033W RSC58
SGTC_481 bay k-8644 50 µM -2.0117768311625 0.0100209021128699 no 3266 0.0221217336543478 4666 2303 A calcium channel antagonist.
SGTC_771 0250-0039 27.3 µM -2.02235552811604 0.0096936964894517 no 3267 0.0215698179500854 4650 3005115
SGTC_1957 st077035 62.4 µM -2.02623986892322 0.00957591617310215 no 3268 0.0213701049372606 4697 705593
SGTC_2390 9097792 176.6 µM -2.0275368312504 0.00953686944337408 no 3269 0.0213037708679878 4710 4497149
SGTC_2759 disulfiram 3.38 µM -2.03239902617276 0.00939172316225707 no 3270 0.021056638303713 4603 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_1676 st018489 23.4 µM -2.04212610595929 0.00910713961138027 no 3271 0.0205695119655788 4650 3696235
SGTC_1488 4013-0813 75.9 µM -2.04327262700071 0.00907409860619779 no 3272 0.0205127288656758 4722 2910057
SGTC_1415 3966-0071 78.1 µM -2.05524706434569 0.00873523821416778 no 3273 0.0199275736959323 4632 2893185
SGTC_1629 st005085 44.9 µM -2.06947403576282 0.00834709795256379 no 3274 0.0192508126691847 4670 24207091
SGTC_2315 7733312 200 µM -2.07166191988397 0.00828877145462984 no 3275 0.0191484904906834 4633 726316
SGTC_1274 0865-0114 173 µM -2.07254030795172 0.00826545551489505 no 3276 0.0191075406243514 4699 870624
SGTC_1904 st060225 78 µM -2.07974178495521 0.0080764616716461 no 3277 0.018774611635338 4689 66595
SGTC_1231 0242-0792 125 µM -2.08386502141993 0.00796997121275246 no 3278 0.0185862234202929 4694 3707635
SGTC_711 k292-0785 179 µM -2.08565595434365 0.00792410285287983 no 3279 0.018504899457569 4655 4146315
SGTC_479 n-linoleoylglycine 10 µM -2.10015555544461 0.00756121692344051 no 3280 0.0178575797924015 4722 6433346 An anti-infammatory.
SGTC_2689 tacrolimus 100 µM -2.10049807878238 0.00755282440696209 no 3281 0.0178425247209349 4681 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12).
SGTC_409 arachidonic acid 100 µM -2.10459426849354 0.00745309335672771 no 3282 0.0176633204857751 4707 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes.
SGTC_2236 dapsone 200 µM -2.11885500161707 0.00711487633026592 no 3283 0.0170513614062961 4726 2955 A bacterial DFR inhibitor. An anti-cancer agent.
SGTC_1336 1486-0901 104 µM -2.12108489059093 0.00706323347371798 no 3284 0.0169573296103077 4719 5006114
SGTC_2154 5570129 200 µM -2.12405693551834 0.00699491712012817 no 3285 0.016832691472799 4733 673366
SGTC_722 3534-0461 190 µM -2.12414040520374 0.00699300690939379 no 3286 0.0168292023603057 4706 658262
SGTC_1609 st001574 46.4 µM -2.1251762374986 0.00696934008570468 no 3287 0.0167859550230635 4696 3960012
SGTC_741 4582-0002 126 µM -2.13542396749606 0.00673898224801851 no 3288 0.0163631973315696 4723 2912688
SGTC_1838 st055369 84.5 µM -2.14285803140748 0.00657610922256589 no 3289 0.0160622499187206 4702 676036
SGTC_2633 5,7-dihydroxyisoflavone 100 µM -2.14747715761333 0.00647667098051082 no 3290 0.0158776569009534 4698 5377381
SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM -2.15250766913128 0.00636989190573408 no 3291 0.015678695955998 4726 7104
SGTC_1732 st034308 51.822 µM -2.15375540415027 0.00634364948401758 no 3292 0.0156296793471149 4644 830119
SGTC_1926 methyl fluorone black 53.6 µM -2.15639543078828 0.00628843955332164 no 3293 0.01552640058261 4410 72721 Reacts with homocysteine.
SGTC_1857 st056007 79.3 µM -2.16350411894129 0.0061418874483258 no 3294 0.0152512136372712 4719 619834
SGTC_2241 6772625 37.8075 µM -2.1724112271242 0.00596253522282736 no 3295 0.0149123294660919 4565 2285411
SGTC_24 0417-1663 219 µM -2.17539138523443 0.00590357250901974 no 3296 0.0148003997615446 4726 4329390
SGTC_1290 0986-0249 10.2 µM -2.17830046148448 0.00584651550550986 no 3297 0.0146918374217831 4631 53329
SGTC_905 2-aminofluorene 215 µM -2.1828677864364 0.00575792119670294 no 3298 0.0145227739642992 4734 1539 An established DNA mutagen. YPR165W RHO1
SGTC_1493 4348-0038 111 µM -2.18293542609328 0.00575661816386422 no 3299 0.0145202828597468 4733 800424
SGTC_403 arphamenine a 50 µM -2.19103228655885 0.00560251563069851 no 3300 0.0142247280576954 4730 5487158 An arginine aminopeptidase inhibitor.
SGTC_1187 1391-0724 117 µM -2.20070165848908 0.00542329265364342 no 3301 0.0138785756679574 4749 6997986
SGTC_2572 astragaloside iv 100 µM -2.20609630729698 0.00532553280321435 no 3302 0.0136886286116898 4689 45006101 An anti-inflammatory agent.
SGTC_2433 5607874 27.82 µM -2.21419643803073 0.0051816873873549 no 3303 0.0134076343991429 4700 2252428
SGTC_2058 5236698 133 µM -2.22703821693592 0.00496071640476668 no 3304 0.0129723598704074 4714 766665
SGTC_1288 0973-0013 65.5 µM -2.23153810786727 0.00488529568871904 no 3305 0.0128227530884342 4747 4315430
SGTC_2674 ligustilide 100 µM -2.26048345611724 0.00442411658894756 no 3306 0.011895631034677 4770 5319022 A signalling regulator.
SGTC_1806 st050005 60.3 µM -2.26321965099923 0.00438260072082757 no 3307 0.0118110762189728 4761 5194765
SGTC_2091 4-phenylthiadiazole 200 µM -2.26598802003676 0.00434095129804139 no 3308 0.0117260583761643 4740 270010
SGTC_1966 st070145 16.1 µM -2.2766202329454 0.00418426128002816 no 3309 0.0114044567919655 4727 3748532
SGTC_748 act1.228 77.9 µM -2.2798008050982 0.00413838161290861 no 3310 0.0113097526222173 4735 4421505 YNR035C ARC35
SGTC_1249 0481-0015 10.2 µM -2.32893354606956 0.00348461886686114 no 3311 0.00993129322678772 4694 4227577
SGTC_1474 0330-0125 5.35 µM -2.33317488644245 0.00343278539136584 no 3312 0.00981948417355275 4778 X1474
SGTC_2679 rapamycin 1 nM -2.34253437701218 0.00332084624162959 no 3313 0.00957663470798524 4612 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2
SGTC_1341 1486-1360 280 µM -2.34648603521561 0.00327457806071338 no 3314 0.0094756881843725 4758 3976547
SGTC_1683 st010134 710 nM -2.36193242153113 0.00309923484848301 no 3315 0.00908997793582457 4715 3818134
SGTC_307 1501-1223 22.3 µM -2.39525011980672 0.00274948839135646 no 3316 0.00830451546885655 4760 2830329
SGTC_1472 k841-0093 193 µM -2.43411873360719 0.00238676395073741 no 3317 0.00746404868729073 4765 X1472
SGTC_614 0462-0418 107 µM -2.45880144013102 0.00217950224134876 no 3318 0.00697008467479776 4626 5188303
SGTC_2029 5175081 200 µM -2.49372889420851 0.001914047946181 no 3319 0.00632045260846716 4739 1380876
SGTC_833 3852-0053 558 µM -2.49585778124424 0.00189886007874598 no 3320 0.00628264841034012 4772 3123681
SGTC_2405 ticlatone 3.52 µM -2.50517380485328 0.00183367780378735 no 3321 0.00611956170230538 4641 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W
SGTC_1441 4106-0040 13 µM -2.5360780233633 0.0016317515831907 no 3322 0.00560508773047757 4791 2904180
SGTC_2414 st077232 92.9 µM -2.54156986042675 0.00159806454151259 no 3323 0.00551779450104349 4728 729801
SGTC_750 4073-0104 132 µM -2.55345890024268 0.00152729804293546 no 3324 0.00533294328372568 4552 22330957
SGTC_765 1319-0117 244 µM -2.59497791726353 0.00130200485096892 no 3325 0.00472984982863738 4768 3487746 YGL099W LSG1
SGTC_58 0957-0393 9 µM -2.60119954677947 0.00127099404829113 no 3326 0.0046449200023384 4351 6997992
SGTC_16 erodoxin 22.806 µM -2.61104546110884 0.00122329653431949 no 3327 0.0045132946736199 4790 3967339 Erodoxin inhibits Ero1. YML130C ERO1
SGTC_2357 9067248 200 µM -2.63794421492092 0.00110121720983613 no 3328 0.00417051509167259 4731 9150235
SGTC_1836 st055642 81 µM -2.66066788331965 0.00100689961924789 no 3329 0.00389929191662552 4765 8571
SGTC_1197 1601-0112 267 µM -2.66632564942262 0.000984598582753298 yes 3330 0.00383426856282467 4772 7350313
SGTC_836 0330-0104 1.35 µM -2.67389883859589 0.000955457056616664 yes 3331 0.00374875320654434 4788 46494820
SGTC_2087 5276107 200 µM -2.6808821777962 0.000929289372654168 yes 3332 0.00367141821610654 4775 144405
SGTC_2368 9071271 200 µM -2.70363831198448 0.000848519480134239 yes 3333 0.00342924489175384 4770 27209959
SGTC_664 1222-0054 14.9 µM -2.76392394558666 0.000664728766392648 yes 3334 0.00285554245462509 4774 6813991
SGTC_1704 st028805 70.8 µM -2.80831199096627 0.000553707897587759 yes 3335 0.0024900976287214 4801 2876101
SGTC_1335 1486-0900 202 µM -2.83003448765217 0.000505869365364996 yes 3336 0.00232714934063976 4787 X1335
SGTC_2135 5326629 150.42 µM -3.03257326286834 0.000211517177610463 yes 3337 0.00121239114818657 4779 5020077
SGTC_2815 7968870 71.43 µM -3.0383702329098 0.000206141634046418 yes 3338 0.00118930762097529 4767 2977326 YHR190W ERG9
SGTC_1227 3909-8010 46.6 µM -3.04471710135514 0.0002004026420364 yes 3339 0.00116449634594755 4797 15982272
SGTC_1848 st056003 16.4 µM -3.0472327371847 0.000198169527501146 yes 3340 0.00115479404653099 4785 146492
SGTC_1802 st050112 57.9 µM -3.12674750613182 0.000138472974096388 yes 3341 0.000883758281910128 4796 4662563
SGTC_35 0133-0054 64.071 µM -3.21642264499559 9.15156765096405e-05 yes 3342 0.000648997602322506 4771 99677
SGTC_2290 7904846 200 µM -3.2204643019022 8.98009879736943e-05 yes 3343 0.000639915654816043 4798 2962154
SGTC_501 nsc-95397 161 µM -3.28325707056111 6.6752079935884e-05 yes 3344 0.000513075219527837 4800 262093
SGTC_1638 st008370 60.6 µM -3.31647160128056 5.69401283438077e-05 yes 3345 0.000455809259344089 4779 24207134
SGTC_1192 1488-0095 21.4 µM -3.41718872031162 3.48497099743174e-05 yes 3346 0.000316357015756015 4804 915875
SGTC_3159 9100096 49.47 µM -3.41824239959613 3.46687266729858e-05 yes 3347 0.000315134738728475 4787 25236875
SGTC_2682 pyrogallin 40.03 µM -3.57002395979462 1.61274331352815e-05 yes 3348 0.000178474288847642 4810 822798 An ATP competetive kinase inhibitor.
SGTC_1709 st033179 39.1045 µM -3.97425945179696 1.81056973889906e-06 yes 3349 3.5299286137264e-05 4810 573381
SGTC_1107 amlodipine 47 µM -3.99180231698018 1.63857333999318e-06 yes 3350 3.27865125561215e-05 4632 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.
SGTC_2802 7925815 54.55 µM -4.04178183885454 1.2302365549413e-06 yes 3351 2.65232868629887e-05 4803 1262923
SGTC_42 0133-0086 60.653 µM -4.48455759434434 8.39512663852721e-08 yes 3352 3.65326847727817e-06 4800 162923 Model of phenazepam hydroxylation.
SGTC_2630 antimycin a 100 µM -4.80255933309299 1.03826910654023e-08 yes 3353 7.83251898251934e-07 4805 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain.
SGTC_36 0335-0881 14.2 µM -4.82979427520868 8.62636905639018e-09 yes 3354 6.83370929963617e-07 4805 23828853
SGTC_493 zm226600 134 µM -5.0755820510022 1.54845211537975e-09 yes 3355 1.93155802826521e-07 4807 5240098 A potassium channel opener. YCR052W RSC6
SGTC_502 l-744,832 89.3 µM -5.18036854909879 7.26343630788006e-10 yes 3356 1.10723967684108e-07 4810 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.