SGTCid condition conc unit YIP1|YGR172C.score YIP1|YGR172C.strain.pval YIP1|YGR172C.strain.significant YIP1|YGR172C.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene SGTC_2809 7964133 12.99 µM 5.8160128457019 1.53448177232275e-10 yes 1 3.01339185038144e-09 3 1253665 SGTC_864 0469-0573 172 µM 4.31397598698903 1.42081386209973e-06 yes 2 8.0172185266761e-06 2 689425 SGTC_1266 0828-0227 32.9 µM 4.16820527394404 3.01438564949958e-06 yes 3 1.5350369750494e-05 9 3913820 SGTC_1203 3992-3522 103 µM 4.08106969590417 4.67276050344508e-06 yes 4 2.24144545355513e-05 11 5322312 SGTC_1988 st071872 53.4 µM 3.84594914939764 1.46236623298689e-05 yes 5 6.00433339449492e-05 1 16414116 SGTC_142 0335-0849 62.6745 µM 3.8210472590691 1.64429619515472e-05 yes 6 6.64430911380406e-05 20 3889043 YPR107C YTH1 SGTC_2196 6573537 42.6665 µM 3.51122837665421 6.67982928369962e-05 yes 7 0.000223020514548343 4 2903087 SGTC_1445 4239-0156 97.7 µM 3.31350053628583 0.000154666039681793 yes 8 0.000460679652063093 7 4008346 SGTC_2107 5363541 170.161 µM 3.23168183472867 0.000216199207569878 yes 9 0.000615319986731327 16 244052 SGTC_1895 st058434 18.3 µM 3.14262810635978 0.000308730399676933 yes 10 0.000837192130095286 11 5393175 SGTC_1079 idarubicin 2.36 µM 3.13288035654303 0.00032083980849865 yes 11 0.000865499931297519 12 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM 3.10962030936163 0.000351542549667167 yes 12 0.000936639888300124 21 1377 SGTC_2444 5485484 36.41 µM 3.0906979841095 0.00037851044080537 yes 13 0.00099843314814192 18 6790631 SGTC_1891 st059073 26.2 µM 3.03414312298878 0.000470991735707129 yes 14 0.00120609981409937 13 688754 SGTC_2531 methyl deoxycholate 70.07 µM 2.99393804140871 0.000549020701695908 yes 15 0.00137700932198056 18 16667744 Haematoxylin. SGTC_1920 st075728 45.7 µM 2.98863184726106 0.000560168279951797 yes 16 0.00140114782269669 14 3400306 SGTC_2859 9028643 45.46 µM 2.98828117421448 0.000560912317687452 yes 17 0.00140275660835881 6 17151580 SGTC_1927 st060202 13.8 µM 2.9624904429624 0.000618206597798528 yes 18 0.00152580641328434 18 688887 SGTC_875 0709-0210 25.7 µM 2.92860503824763 0.000701705842358623 yes 19 0.00170243384062651 23 6251364 SGTC_2504 purpurogallin 52.29 µM 2.91790073807727 0.000730170629913545 yes 20 0.00176198254810246 12 5281571 An antioxidant. SGTC_2060 5238662 140 µM 2.90843406141222 0.000756227116635598 yes 21 0.00181621885016825 17 790130 SGTC_1220 1838-0075 193 µM 2.88718602650533 0.000817859280933253 yes 22 0.00194352168631218 10 5529645 SGTC_325 2810-4341 181 µM 2.84462813180609 0.000955421721047635 yes 23 0.00222316493616415 16 774970 SGTC_2064 5220758 200 µM 2.83267243835474 0.000997723166098943 yes 24 0.00230803306823542 28 788518 SGTC_2983 9022671 12.99 µM 2.82854695543366 0.00101271426528988 no 25 0.00233799205010902 15 6405161 SGTC_884 0851-0618 334 µM 2.80833055329461 0.00108920875449755 no 26 0.00248995408829241 18 9642473 SGTC_415 dibenzyl ketone 100 µM 2.80150127948833 0.00111622293855365 no 27 0.00254327197104263 14 7593 SGTC_2663 amphotericin b 100 µM 2.77737286141927 0.00121665693384427 no 28 0.00274001372168493 25 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_3230 9131665 49.47 µM 2.74504648208769 0.00136418417118047 no 29 0.00302511637783614 4 15943720 SGTC_103 0844-0104 51.839 µM 2.7204225767631 0.00148733255716789 no 30 0.00325992689215459 75 5375804 SGTC_763 3453-1109 128 µM 2.69751242081881 0.00161093317844186 no 31 0.00349298392700294 23 1560353 SGTC_1923 st058458 19.1 µM 2.69523940475468 0.00162369302726758 no 32 0.00351690366979859 34 3534982 SGTC_2506 ethyl hematommate 54.16 µM 2.67039992703704 0.0017692577268316 no 33 0.00378804755301728 19 3940691 An allergen. SGTC_1398 3558-0053 112 µM 2.66650995658599 0.00179309988462118 no 34 0.00383216680667455 4 4532369 SGTC_2127 5253358 187.912 µM 2.63485675256498 0.00199824012841715 no 35 0.00420863988688351 24 20612 SGTC_2845 9003024 42.97 µM 2.61461845380334 0.00214033843505205 no 36 0.00446635900268302 34 2990173 SGTC_1845 st056753 3.01 µM 2.556968052106 0.00259674612842653 no 37 0.00527944572603647 33 5375839 SGTC_2994 9053520 71.4286 µM 2.54369494828128 0.0027135591407332 no 38 0.00548434151180053 28 4647384 SGTC_193 1273-0060 1.558 µM 2.52061025190981 0.00292806947092256 no 39 0.00585757657324896 19 2847393 YHR072W ERG7 SGTC_109 0132-0036 33.701 µM 2.51056177997329 0.00302612824613022 no 40 0.00602696140497586 20 67274 A color developer. SGTC_728 3030-5151 22.5 µM 2.48038440263186 0.00333864906204618 no 41 0.00656204054123447 13 3125388 SGTC_2505 galangin 7.89 µM 2.44248553221609 0.00377208417918101 no 42 0.00729325712964006 36 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_1454 4239-0054 42.6 µM 2.43949168904244 0.00380838468668732 no 43 0.00735397049150205 30 1340767 SGTC_2685 mycophenolic acid 18.85 µM 2.40984951185568 0.00418505530518663 no 44 0.00797955088440489 13 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_3153 9100258 49.47 µM 2.39016129271491 0.00445331974471914 no 45 0.00842048748430966 21 25236848 SGTC_1727 st034309 9.9045 µM 2.38324567095736 0.0045511328254139 no 46 0.00858036887380246 47 870305 SGTC_1038 k292-0204 154 µM 2.37603933388086 0.00465509398204698 no 47 0.0087497986266882 30 4454212 SGTC_1134 3477-0009 42.5 µM 2.37312793528917 0.00469769227468878 no 48 0.00881907668565553 57 3973534 SGTC_57 miconazole 162.5 nM 2.37196203237273 0.00471484852844466 no 49 0.0088469544105817 60 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_3016 9080866 49.47 µM 2.35978431917984 0.00489741185505407 no 50 0.00914278137517363 35 17066299 SGTC_1237 0330-0133 46.1 µM 2.35278642138828 0.00500514811031095 no 51 0.0093166665991667 43 X1237 YHR072W ERG7 SGTC_1749 st037932 54.2 µM 2.34638444052191 0.00510555356447472 no 52 0.009478271758116 41 594497 SGTC_1705 st027868 56.3335 µM 2.31734682899868 0.00558382797281668 no 53 0.0102424231355093 30 292948 SGTC_1620 st003704 16.5 µM 2.31182978932513 0.00567907015216287 no 54 0.0103935325504747 34 2834414 SGTC_320 4092-0846 5.34 µM 2.30854401115298 0.00573647622986049 no 55 0.0104844489547624 57 1359356 SGTC_455 paf C-16 10 µM 2.29665382234972 0.00594853810817643 no 56 0.0108192628333103 38 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis. SGTC_1049 3226-0134 66 µM 2.29255091068856 0.0060233105940993 no 57 0.0109369366592557 37 5702385 SGTC_3111 9122088 49.47 µM 2.29155695268071 0.00604154961977675 no 58 0.0109656109517413 20 16876704 SGTC_137 0438-0332 85.389 µM 2.28562869368768 0.0061513526431506 no 59 0.0111379950252294 88 2063393 YER012W | YPR107C PRE1 | YTH1 SGTC_899 1083-0020 478 µM 2.26142035711316 0.00661830542940753 no 60 0.0118666196748595 41 767123 SGTC_2524 avocatin b 10.57 µM 2.2574809286679 0.006697187576703 no 61 0.011989019928777 12 6710748 SGTC_1667 st014849 34.6 µM 2.25357333633045 0.00677625197865677 no 62 0.0121115111589994 30 5348460 SGTC_1748 st037455 53.6035 µM 2.25280118810533 0.00679197248462793 no 63 0.0121358436292282 35 580690 SGTC_2435 5706476 10.6 µM 2.22004646555282 0.00748921523677442 no 64 0.0132078068122701 28 5725375 SGTC_431 k089-0097 107 µM 2.21957809147281 0.00749962665653834 no 65 0.0132237104126039 54 5499420 SGTC_482 fipronil 114 µM 2.19159826898159 0.00814517875892604 no 66 0.0142042635261994 14 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels. SGTC_102 gallobenzophenone 83.616 µM 2.18333248253722 0.00834500456168349 no 67 0.0145056670616219 37 70837 SGTC_3248 9135562 49.47 µM 2.17778836780679 0.00848143377908033 no 68 0.0147108981545767 36 17650701 SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM 2.17103209700804 0.00865033475912956 no 69 0.0149643731010943 35 616764 SGTC_1499 4480-0877 67.3 µM 2.15511599142945 0.00905993066260108 no 70 0.0155763793184925 29 2861909 SGTC_61 0978-8327 98.565 µM 2.12037430770946 0.010013428478764 no 71 0.0169872458096311 44 6150059 YHR072W ERG7 SGTC_2502 avocadyne acetate 18.59 µM 2.11395941404175 0.0101987593595419 no 72 0.0172593669621229 43 3952079 SGTC_2795 7780010 54.55 µM 2.10345051975389 0.0105088371275606 no 73 0.01771320312599 51 953673 SGTC_1424 4048-1941 275 µM 2.09802290218554 0.0106721791641912 no 74 0.017951561152152 37 X1424 SGTC_117 lucigenin 22.078 µM 2.08349054210203 0.0111204551318508 no 75 0.0186032664535355 45 65100 An acridine derivative; a dye stuff and potential carcinogen. SGTC_2052 5265182 7.135 µM 2.07877917959656 0.0112692582581186 no 76 0.018818825704366 46 1239884 SGTC_3246 9135460 32.98 µM 2.07218972228574 0.0114802805017883 no 77 0.0191238757574508 36 41446951 SGTC_423 5-fluorouracil 457 µM 2.05976026028879 0.0118876805160834 no 78 0.0197107326957166 81 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_1268 0828-0275 2.46 µM 2.04328824940188 0.0124468672860045 no 79 0.020511956061932 53 745337 SGTC_2054 5233173 129 µM 2.03942750515249 0.0125811786342116 no 80 0.0207036898130644 19 6889 SGTC_1649 st011737 51.3 µM 2.00876435582773 0.0136931777846508 no 81 0.0222810650173014 34 1761035 SGTC_2201 6605497 169.863 µM 2.00147545563658 0.0139696546120385 no 82 0.0226705881223025 39 670741 SGTC_474 dl-dihydrosphingosine 5 µM 1.99995174160108 0.014028055216712 no 83 0.0227527375915204 47 3058739 A sphingolipid protein kinase C inhibitor. SGTC_3214 9129694 49.47 µM 1.99831571283541 0.0140909947538855 no 84 0.0228412215319317 56 17158655 SGTC_1685 st024049 53.0905 µM 1.99650137482029 0.014161078453529 no 85 0.0229396881296867 50 1941139 SGTC_2995 9067767 71.4286 µM 1.99540294319994 0.0142036541241085 no 86 0.0229994750999092 40 11673567 SGTC_855 0428-0020 25 µM 1.97122591560321 0.0151690828407716 no 87 0.0243490204488708 58 6812414 SGTC_2104 5389443 200 µM 1.94813100553449 0.0161434186787119 no 88 0.0256996448475854 60 2244536 SGTC_3212 9128307 49.47 µM 1.92150203758825 0.0173329483874122 no 89 0.0273342228678519 57 27243542 SGTC_1812 st052057 4.327 µM 1.91519582581537 0.0176253686765479 no 90 0.0277337673158551 71 3645418 SGTC_2117 5521686 200 µM 1.90263351469058 0.0182204483707826 no 91 0.0285441914009929 57 803312 SGTC_683 panaxydol 45 µM 1.90190181204668 0.0182556307553731 no 92 0.0285919961315825 36 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis. SGTC_413 propylparaben 100 µM 1.89940692213405 0.0183760277925403 no 93 0.0287554970351618 57 7175 A pharmaceutical preservative. SGTC_3202 9113761 49.47 µM 1.89460277813604 0.0186097693757145 no 94 0.0290725232358326 70 4798415 SGTC_3251 9135047 49.47 µM 1.88450739130877 0.0191092092499297 no 95 0.0297481879862468 40 17682963 SGTC_1334 1486-0610 236 µM 1.88344884021339 0.0191622320874381 no 96 0.0298197834113269 67 3742339 SGTC_200 k038-0079 37.545 µM 1.87800222460894 0.0194370346358191 no 97 0.0301904303803009 69 3436683 SGTC_977 1348-1378 135 µM 1.87344581632714 0.0196694878388114 no 98 0.0305034241481787 61 X977 SGTC_475 α-linolenic acid 10 µM 1.86983609232645 0.0198553160076069 no 99 0.0307532913262821 75 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_716 1683-5115 658 µM 1.86912096080625 0.019892307176091 no 100 0.0308029937157329 54 723597 SGTC_1736 st036774 51 µM 1.86826328629471 0.0199367486885757 no 101 0.0308626906750982 54 1272247 SGTC_807 1315-0151 48 µM 1.86600351320391 0.0200542453149762 no 102 0.0310204369858527 83 4011080 SGTC_2938 9059746 27.26 µM 1.85604120062143 0.0205792610577471 no 103 0.0317238428506834 69 6471769 SGTC_1416 3966-0321 25.3 µM 1.85482675002209 0.0206440520327124 no 104 0.0318104854038041 64 582530 YLR208W SEC13 SGTC_86 0417-1630 471.922 µM 1.85300334402737 0.0207416551951318 no 105 0.0319409396759591 109 3634867 SGTC_3117 9124945 49.47 µM 1.84109260567855 0.0213888722483931 no 106 0.0328039945423691 44 17592065 SGTC_410 α-linolenic acid 100 µM 1.83163722183755 0.0219147511231876 no 107 0.033502743709396 62 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_328 k915-0120 63.5 µM 1.83143936844091 0.0219258706989595 no 108 0.033517494866726 44 6624543 SGTC_2328 6201408 200 µM 1.82538793491553 0.022268276171572 no 109 0.0339712543433239 86 2890418 SGTC_252 miconazole 1.30953 nM 1.82423884678566 0.0223338015685164 no 110 0.0340579855376769 91 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_1906 st060206 94.7 µM 1.81426533710457 0.0229093910352993 no 111 0.0348184426968224 68 5133468 SGTC_1541 2',3',6-trimethoxyflavone 64 µM 1.80611852896153 0.0233887847659956 no 112 0.0354499135820137 70 688801 SGTC_1972 st070201 17.4 µM 1.80414972414434 0.02350589600498 no 113 0.0356039192135216 54 2829099 SGTC_208 k072-0098 12.366 µM 1.80065070219238 0.0237152472369493 no 114 0.0358789761494059 93 5948901 SGTC_1532 4',5'-dihydroxyflavone 78.7 µM 1.79360680343248 0.0241414503525779 no 115 0.0364379749324836 77 165521 SGTC_3328 9140624 29.0385 µM 1.79355995212521 0.0241443065706054 no 116 0.0364417167434583 64 4904392 SGTC_1276 0871-0068 94.2 µM 1.78861135831766 0.0244475925021565 no 117 0.0368387136717981 73 3414906 SGTC_913 3487-1245 167 µM 1.78499218127764 0.0246714212934849 no 118 0.0371312925569586 80 4016153 SGTC_2324 6149169 200 µM 1.78443045925408 0.0247063147771783 no 119 0.0371768726632005 62 2888231 SGTC_2284 7945075 39.21 µM 1.77721257267194 0.0251583769981461 no 120 0.0377666358135372 64 1245402 SGTC_80 0159-0065 512.242 µM 1.77301635285179 0.0254243619205538 no 121 0.0381129985936389 28 1548079 SGTC_2960 9079389 5.97 µM 1.76797663709186 0.0257469224892704 no 122 0.0385324047381754 50 16457355 SGTC_165 k038-0023 64.381 µM 1.76561848664629 0.0258990251538306 no 123 0.0387299382059979 84 46368543 SGTC_1138 3761-0006 1.03 µM 1.76213550636245 0.0261250550058665 no 124 0.0390232027593875 38 12061087 SGTC_1997 st073024 93.8 µM 1.75928945827118 0.0263109733850882 no 125 0.0392641781053242 57 686268 SGTC_2866 9034245 58.44 µM 1.75850931193219 0.0263621292314246 no 126 0.0393304442754605 44 6462273 SGTC_1072 oxiconazole 14.9 nM 1.74545934390855 0.0272302423210454 no 127 0.0404524717478958 89 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_2453 5731132 22.18 µM 1.74434142690675 0.0273057050156981 no 128 0.0405497859858182 85 1362040 SGTC_1232 0279-0259 161 µM 1.739989232541 0.0276011543178725 no 129 0.0409304543282533 62 1560000 SGTC_1399 3562-5772 25 µM 1.73835911606015 0.0277124987652239 no 130 0.0410737779322455 70 23847490 SGTC_2282 7944268 200 µM 1.73172399811925 0.02816957737328 no 131 0.0416613578542961 75 2970414 SGTC_1483 3453-0561 55.9 µM 1.72640698260962 0.0285403692488912 no 132 0.042137110232973 85 4546991 SGTC_190 3970-0790 3.722 µM 1.72624099257174 0.0285520099121225 no 133 0.0421520330589845 63 2832352 SGTC_673 1082-0474 110 µM 1.72616599068909 0.0285572709908597 no 134 0.0421587772762432 131 3098046 SGTC_1453 4237-0541 195 µM 1.71244321286834 0.0295335305250326 no 135 0.0434075106346605 82 739892 SGTC_2151 5563267 85.4165 µM 1.70825549131105 0.0298369112694121 no 136 0.0437944730245133 86 5310824 SGTC_312 4092-0653 6.84 µM 1.70753613392204 0.0298892846237456 no 137 0.0438612237891844 105 1148278 SGTC_576 1073-0113 22.7 µM 1.705203054868 0.0300596711473551 no 138 0.0440782802397633 117 5439563 SGTC_1968 st069590 43.6 µM 1.70263442055265 0.0302481910723008 no 139 0.0443182522036861 92 6384066 SGTC_1969 st069479 40.1 µM 1.69665014755543 0.0306911981610917 no 140 0.0448814114707176 65 3895485 SGTC_1278 0874-0585 172 µM 1.69499421664405 0.0308147289964294 no 141 0.0450382589491728 76 766306 SGTC_2532 xanthone 78.9 µM 1.69139656115655 0.031084529451088 no 142 0.0453805443245115 52 7020 An insecticide. SGTC_3118 9124250 49.47 µM 1.68085469653848 0.0318863738922198 no 143 0.0463955707212681 69 1504786 SGTC_1099 5-nonyloxytryptamine 2.85 µM 1.67848020356294 0.0320693225745058 no 144 0.0466266959623937 82 23581825 A 5-HT1D beta serotonin receptor agonist. SGTC_2069 5228469 200 µM 1.66715432127378 0.0329539171206485 no 145 0.0477418614979963 81 2835210 SGTC_3150 9097574 49.47 µM 1.6656388372394 0.033073793375052 no 146 0.0478926854112138 69 17217476 SGTC_3107 9121808 49.47 µM 1.66409447523854 0.0331963233082715 no 147 0.0480467754826603 56 662681 SGTC_2292 7671323 168.05 µM 1.66385070976938 0.0332156978265155 no 148 0.0480711336120088 119 937504 SGTC_1351 1496-0003 46.5 µM 1.66079680748114 0.0334592126896924 no 149 0.0483771312868461 67 3891978 SGTC_1954 st077032 68.9 µM 1.65525867647525 0.0339045662677393 no 150 0.0489360187108466 71 698907 SGTC_1528 arabinosylhypoxanthine 74.6 µM 1.65297412045598 0.0340896958988865 no 151 0.0491680653301298 81 804 An inhibitor of viral and cellular DNA polymerases. SGTC_1839 st053978 48 µM 1.6496630512984 0.0343594838411535 no 152 0.049505935647059 66 3788398 SGTC_1666 st014829 29 µM 1.64750764761314 0.0345360484934884 no 153 0.0497268727992933 68 3858230 SGTC_862 0452-0056 10.2 µM 1.6465710175387 0.0346130065934589 no 154 0.0498231258486539 52 1575396 YLR359W | YHR072W ADE13 | ERG7 SGTC_661 1304-0007 33.6 µM 1.63600078626883 0.0354913115698123 no 155 0.0509197114194046 81 3117130 SGTC_2235 salicylic acid 500 µM 1.62806828199175 0.0361623753413771 no 156 0.0517552040525343 70 338 A COX inhibitor and kinase inhibitor. SGTC_2874 9043904 71.43 µM 1.62634910650377 0.0363091732957355 no 157 0.0519377054243557 89 4463428 SGTC_2399 5884133 200 µM 1.62121330580107 0.0367506195011346 no 158 0.0524859500603689 96 722445 SGTC_2771 fluoxetine 41.05 µM 1.61386226997344 0.0373901038629741 no 159 0.053278652065924 66 3386 A selective serotonin reuptake inhibitor. SGTC_3289 9119912 71.43 µM 1.61360428654162 0.0374127105153941 no 160 0.0533066432411404 77 17014829 SGTC_885 0865-0106 16.8 µM 1.61048573401532 0.0376868681419373 no 161 0.0536459286938032 88 2793380 SGTC_2076 5212012 200 µM 1.6063728008948 0.0380509490562738 no 162 0.054096011661665 70 604802 SGTC_3058 9093861 49.47 µM 1.60487516318866 0.0381842319432941 no 163 0.0542606402096141 89 17217477 SGTC_1365 1672-3266 55.4 µM 1.59901471588717 0.0387094493323962 no 164 0.0549086664075381 100 6415873 SGTC_1491 4138-0063 26.5 µM 1.59506832547998 0.0390664325006813 no 165 0.0553484788120933 74 23883227 SGTC_223 busulfan 5 mM 1.59382730953747 0.0391792448545704 no 166 0.0554873595099806 72 2478 A DNA alkylator. SGTC_3014 9081533 49.47 µM 1.59346888164561 0.0392118764111159 no 167 0.055527521934702 101 21367265 SGTC_1694 st024011 44.9 µM 1.59271705540242 0.0392803951230419 no 168 0.0556118398311721 91 2787533 SGTC_2249 haloperidol 116.36 µM 1.58760956676375 0.0397484562710224 no 169 0.0561873267815306 129 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_732 3970-1727 52.7 µM 1.58675712400205 0.0398270157354927 no 170 0.0562838315182259 85 1275699 SGTC_925 2064-1272 59.6 µM 1.57915572879999 0.0405331402676854 no 171 0.057150170838531 92 6815817 SGTC_486 niguldipine 82 µM 1.57627775044244 0.0408031257199975 no 172 0.0574809034712907 77 1236 A calcium channel blocker. SGTC_1824 st053723 68.6 µM 1.57565418468577 0.0408618148202323 no 173 0.0575527607095512 78 675225 SGTC_1650 st011916 45.8 µM 1.57528650268739 0.040896452597787 no 174 0.0575951640228478 78 242528 SGTC_1827 berberine 7.24 µM 1.57251226613977 0.0411585702895131 no 175 0.0579158983614001 76 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_503 tyrphostin 8 294 µM 1.56322791913843 0.0420457037024079 no 176 0.0589994977363774 96 92970 A tyrosine kinase inhibitor. YOR207C RET1 SGTC_1186 1319-0216 26 µM 1.55896345802689 0.0424583347118685 no 177 0.0595025146433573 100 4565136 SGTC_2476 5806916 10.51 µM 1.55179377482507 0.0431594532679468 no 178 0.0603557879777308 79 2870194 SGTC_1872 amphotericin b 148 nM 1.55058318600244 0.0432787535839441 no 179 0.0605008020593438 85 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1 SGTC_1123 mangostin 811.285 nM 1.54642477877497 0.0436905833395144 no 180 0.0610010068441408 49 5281650 An antioxidant. SGTC_1950 st077106 7.18 µM 1.54558250601576 0.0437743820856981 no 181 0.0611027144187866 82 13831864 SGTC_2394 5221648 200 µM 1.54434214317504 0.0438980233301369 no 182 0.0612527340998796 107 788586 SGTC_1796 st049173 110.4 µM 1.54399656487701 0.0439325212235215 no 183 0.0612945824016275 84 94134 SGTC_1799 st045822 46.1415 µM 1.54345618353509 0.0439865094591474 no 184 0.0613600654302117 98 3674992 SGTC_167 3672-0051 66.205 µM 1.54103408193994 0.0442291536556815 no 185 0.0616542456726691 102 3237971 SGTC_1270 0831-1170 17.3 µM 1.54060389036199 0.044272362524561 no 186 0.061706610259705 93 6764716 SGTC_1231 0242-0792 125 µM 1.53948663105381 0.0443847400948478 no 187 0.0618427695911487 81 3707635 SGTC_2200 6600604 21.907 µM 1.53431561947737 0.0449078544960175 no 188 0.0624760124811448 102 2904777 SGTC_775 4577-0580 57.3 µM 1.53269173337427 0.0450731517710406 no 189 0.0626759134797869 92 2006902 SGTC_3231 9132313 49.47 µM 1.53044475113976 0.0453026818710568 no 190 0.0629533395475984 88 4905967 SGTC_1341 1486-1360 280 µM 1.5299812560461 0.0453501448547026 no 191 0.0630106843012642 86 3976547 SGTC_1059 3448-6867 171 µM 1.52554498972862 0.0458064551950667 no 192 0.0635616105019262 110 3934407 SGTC_1022 4477-0945 21.3 µM 1.52380069959682 0.0459868788936645 no 193 0.0637792523784451 82 4648966 SGTC_472 calcifediol 10 µM 1.52092260119498 0.0462858278499658 no 194 0.0641396307465999 69 5283731 A vitamin D metabolite. SGTC_1948 st076329 66.6 µM 1.5201537963438 0.0463659473753896 no 195 0.0642361633161662 68 24208413 SGTC_108 0509-0257 621.132 µM 1.51770882771781 0.0466214854040677 no 196 0.0645439088328652 111 536624 SGTC_1371 2421-0008 32.7 µM 1.51755667027773 0.0466374255516596 no 197 0.0645630985134004 124 2827552 SGTC_97 0535-0701 19.132 µM 1.51007766872925 0.0474263376284898 no 198 0.0655118034643337 96 2832013 YGL099W LSG1 SGTC_796 1234-0020 70.7 µM 1.50842088410467 0.0476025398866437 no 199 0.0657234206582986 87 46495034 SGTC_2441 5730946 39.09 µM 1.50557820078861 0.0479060860770835 no 200 0.0660877440088414 92 1774275 SGTC_163 TUB2.036 7.546 µM 1.50522092742709 0.0479443456548072 no 201 0.0661336432579222 127 15992207 YJR013W GPI14 SGTC_3216 9129716 49.47 µM 1.50479733509168 0.0479897388639012 no 202 0.0661880945595057 88 8056934 SGTC_1210 3013-0140 750 nM 1.50020323123499 0.0484842672332375 no 203 0.0667808832598043 94 905973 SGTC_490 phenamil 164 µM 1.49451596276348 0.0491021040688463 no 204 0.0675204064297169 90 4755 Irreversibly blocks amiloride-sensitive Na+ channels. SGTC_2669 eugenol 100 µM 1.49373197037765 0.0491877641694611 no 205 0.0676228444149097 56 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism. SGTC_739 1486-1183 203 µM 1.49219260045342 0.0493563050676935 no 206 0.0678243308111947 84 4346692 SGTC_1678 st019265 80.2 µM 1.48454392270519 0.0502005830440526 no 207 0.0688323398911865 86 5367020 SGTC_2313 7726885 200 µM 1.47571437988274 0.0511894796823693 no 208 0.0700102919889943 105 726423 SGTC_1544 7-methoxy-4-methylcoumarin 105 µM 1.47395961113838 0.0513878455453687 no 209 0.0702462330172495 109 390807 SGTC_127 0180-0333 59.125 µM 1.47368137443785 0.0514193545848652 no 210 0.0702837000058123 73 771601 SGTC_3287 9117173 37.0625 µM 1.47004401339095 0.051832684199769 no 211 0.0707749169764088 52 2789709 SGTC_305 1682-2595 20.8 µM 1.46985758930051 0.0518539393329904 no 212 0.0708001639912286 104 226033 SGTC_1455 4262-0120 131 µM 1.46868032723004 0.0519883248402749 no 213 0.0709597579193637 96 1529587 SGTC_2290 7904846 200 µM 1.46637485560461 0.0522522979162564 no 214 0.071273096286167 105 2962154 SGTC_1941 st076221 61.8 µM 1.46266439234706 0.0526793743030261 no 215 0.0717796170279665 112 2828568 SGTC_269 exalamide 29 µM 1.45773288929447 0.0532512748334915 no 216 0.072457091368388 111 3316 A derivative of salicylamide. SGTC_2687 chenodiol 100 µM 1.4569703287089 0.0533401457895966 no 217 0.0725622854036536 107 5702181 A cholesterol synthesis inhibitor. SGTC_2778 tioconazole 65.09 nM 1.4535420648932 0.0537411383415125 no 218 0.0730366546175909 130 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_3034 9090421 49.47 µM 1.45319099132522 0.0537823366482985 no 219 0.0730853663609079 67 17173761 SGTC_1041 0206-0046 107 µM 1.45016633707953 0.0541383150988516 no 220 0.0735060699331925 106 50494 SGTC_206 4546-0025 72.014 µM 1.44909326647747 0.0542650544237983 no 221 0.0736557691077988 104 6620745 YIL048W NEO1 SGTC_375 3970-0961 9.27 µM 1.44687172655873 0.0545281843704166 no 222 0.0739664265796954 100 2898222 SGTC_1019 4262-0212 3.4 µM 1.44498675492018 0.0547522399707653 no 223 0.0742308030199521 118 4677213 SGTC_2914 7968218 45.32 µM 1.44403786809209 0.0548653036938534 no 224 0.0743641618060773 75 2977111 SGTC_247 mechlorethamine 29.705 µM 1.4427106137715 0.0550237609260254 no 225 0.0745510040440105 79 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links. SGTC_427 1354-0053 47.3 µM 1.44156012926065 0.0551614064729924 no 226 0.0747132515133015 81 6813657 SGTC_1693 xanthone 101.9 µM 1.43591248644809 0.0558410472026152 no 227 0.0755136224913698 122 7020 An insecticide. SGTC_379 3970-0972 5.9 µM 1.42583664562292 0.0570699702664929 no 228 0.0769577501552623 98 2898042 YBL034C STU1 SGTC_645 0845-0943 5.41 µM 1.42334648823783 0.057376945548805 no 229 0.0773178683732396 102 1885106 SGTC_2065 5221596 34.26 µM 1.42131116048244 0.057628815139058 no 230 0.0776131602101944 118 788581 SGTC_2479 5617353 43.85 µM 1.41503025883727 0.0584115544399574 no 231 0.0785298121821879 127 2731746 SGTC_1668 st014914 51.6 µM 1.41379235914656 0.0585668045617076 no 232 0.0787114388455125 118 2839556 SGTC_1562 morin hydrate 59.1 µM 1.41136684455873 0.0588719374842977 no 233 0.0790682369638722 108 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase. SGTC_817 1391-0715 46 µM 1.4081097258089 0.0592836479679295 no 234 0.079549290781775 134 1353946 SGTC_737 1950-0117 57.9 µM 1.40810744804272 0.0592839366729594 no 235 0.0795496279651983 115 5393513 SGTC_3081 9117243 49.47 µM 1.4048557550441 0.0596972115024133 no 236 0.0800320878188036 144 45595589 SGTC_2523 spermine 47.74 µM 1.39981716480415 0.0603420473277369 no 237 0.0807840381880576 84 1103 A DNA binding polyamine. SGTC_718 1130-0073 349 µM 1.39288561724777 0.0612380354027283 no 238 0.0818271911963955 108 6740020 SGTC_1155 4088-0394 48.2 µM 1.39156788412572 0.0614095387474299 no 239 0.0820266448864856 119 2326248 SGTC_1397 3532-0190 20.1 µM 1.39106745501241 0.061474767952919 no 240 0.0821024863385904 78 5322280 SGTC_1204 4049-0315 18.3 µM 1.38407931313362 0.0623913127692675 no 241 0.0831670852261768 104 588402 SGTC_1058 3448-5425 97.3 µM 1.38312298432636 0.0625175667551108 no 242 0.0833135796297451 130 7279705 SGTC_1942 st076330 65.2 µM 1.38236279382099 0.0626180686938523 no 243 0.0834301670764518 110 24208414 SGTC_609 0986-0026 86.3 µM 1.38153490589031 0.0627276638647663 no 244 0.083557276456596 112 2848610 SGTC_1159 4092-0538 61.2 µM 1.38082829626587 0.0628213224980525 no 245 0.0836658804885773 122 717301 SGTC_2835 9006588 71.43 µM 1.37960900223847 0.062983191844289 no 246 0.0838535320914108 91 2345538 SGTC_356 1634-0012 32.5 µM 1.3757263392257 0.0635008061288879 no 247 0.0844531870771345 131 735457 SGTC_1659 st012954 42.1 µM 1.37428949564862 0.0636931949468414 no 248 0.0846759130474703 97 24207262 SGTC_595 3909-8003 73.7 µM 1.37259944883391 0.0639200669186251 no 249 0.0849384516744646 113 699517 SGTC_1658 st012944 20 µM 1.37240655023194 0.0639460015450302 no 250 0.0849684560702986 118 24207260 SGTC_3237 9133362 49.47 µM 1.36941498411836 0.0643492567483741 no 251 0.0854347965180706 114 43845137 SGTC_2163 5671233 125 µM 1.3688499433821 0.0644256441414711 no 252 0.0855230927519172 126 701023 SGTC_1363 1636-0063 10.4 µM 1.36765533563775 0.0645873741027962 no 253 0.0857099933732667 138 6072185 SGTC_1677 st019204 53.9 µM 1.36622947226482 0.064780824859673 no 254 0.0859334748555905 100 3945625 SGTC_1418 3966-3099 2.4 µM 1.36548187546212 0.0648824329803965 no 255 0.0860508229196335 135 740335 SGTC_218 alverine citrate 93.75 µM 1.36399801742829 0.0650844750341547 no 256 0.0862840948228593 118 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_1552 6-methylflavone 10.6 µM 1.36333166036564 0.0651753649039013 no 257 0.086389004130825 102 689013 SGTC_2493 resveratrol 26.09 µM 1.3628906200164 0.0652355761363454 no 258 0.086458492671015 71 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase. SGTC_3055 9094636 49.47 µM 1.36029674239098 0.065590568390693 no 259 0.0868680194180938 140 25236176 SGTC_1262 0737-0114 49.6 µM 1.35960300467906 0.0656857651903696 no 260 0.0869777934071227 126 765919 SGTC_453 enantio-paf c16 10 µM 1.35554288918598 0.0662450559624029 no 261 0.0876223267731581 144 13871343 A lipid and platelet activating factor SGTC_3129 9127257 49.47 µM 1.35311272649018 0.0665815769953399 no 262 0.0880098102678821 103 837894 SGTC_1709 st033179 39.1045 µM 1.35202220446625 0.0667330183967546 no 263 0.0881841060782212 100 573381 SGTC_2650 prasterone 100 µM 1.35133194843164 0.0668290123020939 no 264 0.0882945611244956 84 16759247 A steroid and weak partial agonist of the androgen receptor. SGTC_1938 st074717 56.4 µM 1.34652303572177 0.0675007553489744 no 265 0.0890669482303481 113 17250979 SGTC_2693 st077581 40.7 µM 1.34623333066291 0.0675413894466481 no 266 0.0891136395246882 117 25238761 SGTC_994 3910-0338 138 µM 1.34434911237942 0.0678061317311375 no 267 0.0894177605285976 126 3479481 SGTC_3245 9134821 49.47 µM 1.33808050458639 0.0686926742121418 no 268 0.0904350975814902 138 17014901 SGTC_1352 1496-0991 99 µM 1.33296396450872 0.0694228882285186 no 269 0.0912718148530732 126 3000039 SGTC_77 0828-0286 12.516 µM 1.33196130942556 0.0695666815431877 no 270 0.0914364513514433 107 745345 SGTC_7 0192-1582 4.227 µM 1.32884726654428 0.0700147367029247 no 271 0.0919491822359616 159 252616 SGTC_3001 9076041 71.4286 µM 1.32797108521515 0.0701412029338828 no 272 0.0920938296405009 98 16004211 SGTC_806 3966-4455 5.86 µM 1.32434154794199 0.0706669551944746 no 273 0.0926948188868292 107 714982 SGTC_1605 st000082 49.1 µM 1.32386305404835 0.0707364922089257 no 274 0.0927742651987344 129 1114022 SGTC_1486 3970-0793 4.53 µM 1.32293719054207 0.0708711923896858 no 275 0.0929281330882792 134 2844330 SGTC_32 0928-0142 34.1 µM 1.32099773647073 0.0711539944292982 no 276 0.0932510594783104 124 2244242 SGTC_2969 9091408 28.7 µM 1.31958353833804 0.0713607518112519 no 277 0.0934870509821948 125 4286311 SGTC_2473 5854593 8.94 µM 1.315680055951 0.0719338385570807 no 278 0.0941407254756974 136 2872951 SGTC_283 0987-0079 11.7 µM 1.31265155444753 0.0723808916864457 no 279 0.0946501945158806 102 411556 SGTC_564 3555-0129 330 µM 1.31263049209601 0.072384008248516 no 280 0.0946537448275633 113 563260 SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM 1.30673478184284 0.0732604359119473 no 281 0.0956514007877861 116 4213774 SGTC_2550 chrysin dimethyl ether 71.87 µM 1.30472102859197 0.0735616434639759 no 282 0.0959939291465212 87 88881 An O-methylated flavonoid and antioxidant. SGTC_2212 7123476 200 µM 1.30216383514422 0.0739454997699641 no 283 0.0964301925499589 96 1085715 SGTC_1691 st019933 84.6 µM 1.29820971993546 0.0745420562625402 no 284 0.0971076394876592 133 6176082 SGTC_605 1315-0399 119 µM 1.29598489804443 0.0748793258365973 no 285 0.0974903439434777 143 24020461 SGTC_1045 1348-1485 165 µM 1.29415396603343 0.0751577562741624 no 286 0.0978061219817662 122 6810614 SGTC_2503 beta-caryophyllene alcohol 24.72 µM 1.29400531916708 0.0751803956530435 no 287 0.0978317917476645 117 61125 An anti-inflammatory. SGTC_1860 st056228 74.6 µM 1.28933007344152 0.0758951066786232 no 288 0.0986416800652725 146 688679 SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM 1.28880862675124 0.0759751405771632 no 289 0.0987323130870127 144 688798 SGTC_2160 5660466 132.927 µM 1.28658973201635 0.0763164248277065 no 290 0.0991186622381507 145 2859134 SGTC_746 1095-0025 46.6 µM 1.2858211346115 0.0764349130658164 no 291 0.0992527462524972 129 6749286 SGTC_1936 st074407 74.3 µM 1.28408262906521 0.0767034401995719 no 292 0.0995565226879568 149 809813 SGTC_342 k048-0088 23.3 µM 1.28174853366266 0.0770650886670518 no 293 0.0999654367865497 128 6820570 SGTC_2756 carbadox 75.1 µM 1.2796826005985 0.0773862674137056 no 294 0.100328393161957 144 2553 A substituted quinoxaline antibiotic. YLR208W SEC13 SGTC_784 4579-0127 173 µM 1.27965479640259 0.0773905968953211 no 295 0.100333284531914 127 1948547 SGTC_274 sirtinol 40.1 µM 1.27934086567913 0.0774394928334727 no 296 0.100388523931276 130 6836442 NAD-dependent acetyltransferase inhibitor. SGTC_1807 st050092 58.9 µM 1.27581747276557 0.0779898855299051 no 297 0.10101002474935 137 5008496 SGTC_2605 digitonin 300 nM 1.27348804028463 0.0783553950249772 no 298 0.101422456908533 156 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_769 0302-0231 76 µM 1.27251361186826 0.0785086766025319 no 299 0.101595345429485 158 571869 YER009W NTF2 SGTC_3155 9099265 49.47 µM 1.27157787021176 0.0786560864407878 no 300 0.101761571833057 121 25236499 SGTC_2850 9015429 58.44 µM 1.25963001692689 0.0805567437737678 no 301 0.103901430954514 135 6457570 SGTC_2508 celastrol 40.54 µM 1.25710832414014 0.0809622906579134 no 302 0.104357206668164 102 122724 Celastrol is a natural product and antioxidant. SGTC_1315 1237-0019 3.69 µM 1.25672293866928 0.0810244051307308 no 303 0.104426989434215 124 825140 SGTC_2362 9071156 126 µM 1.25229383119851 0.0817408502129864 no 304 0.10523140793791 129 653133 SGTC_2024 5144227 134 µM 1.25098628790437 0.0819532665656608 no 305 0.105469740113266 124 3475211 SGTC_2434 5670830 169.91 µM 1.25082709222772 0.0819791570051201 no 306 0.105498784110028 142 1549830 SGTC_141 0443-0274 32.331 µM 1.24705010614133 0.0825952279662556 no 307 0.106189562888952 118 1627241 SGTC_354 2783-3500 4.88 µM 1.24602879275814 0.0827624132685503 no 308 0.106376912397099 154 6740761 SGTC_3354 9151612 71.43 µM 1.24173029560317 0.083468853704702 no 309 0.10716804411104 119 27261949 SGTC_1829 berberine 14.4 µM 1.24088551107184 0.0836082218727321 no 310 0.107324022962386 153 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_3185 9108267 49.47 µM 1.23966104148796 0.0838105387908816 no 311 0.107550396314553 132 4910486 SGTC_324 1315-0088 19.6 µM 1.23784825191815 0.084110737633838 no 312 0.107886166562176 136 6787421 SGTC_74 000s-0487 160.283 µM 1.23702046344446 0.0842480879751952 no 313 0.108039742820779 113 677548 SGTC_822 1487-0950 154 µM 1.23615768593705 0.0843914229409046 no 314 0.108199977912206 121 1958375 SGTC_877 0771-0151 33.1 µM 1.23583553954509 0.0844449886604802 no 315 0.108259850797197 131 6166523 SGTC_558 k064-0027 21.3 µM 1.23302650665274 0.0849131492795987 no 316 0.108782937484425 150 5088526 SGTC_2262 9014885 67.46 µM 1.23137921354993 0.085188594957315 no 317 0.109090533799253 120 6457424 SGTC_1071 trifluoperazine 6.31 µM 1.229757445237 0.0854604261028806 no 318 0.109393974042986 143 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM 1.22705171911872 0.0859153890589846 no 319 0.109901576361864 119 2724278 An inhibitor of dopamine biosynthesis. SGTC_1219 1469-0211 33.1 µM 1.22636195926017 0.0860316603482125 no 320 0.110031247319676 145 6822282 SGTC_1983 st071813 46.9 µM 1.22591091514522 0.0861077554943696 no 321 0.110116100403914 141 11838595 SGTC_1382 3002-2117 298 µM 1.22396811049919 0.086436099498267 no 322 0.110482128846492 138 1497314 SGTC_409 arachidonic acid 100 µM 1.22116460656852 0.0869115549333829 no 323 0.111011851034688 132 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes. SGTC_2926 9010726 65.15 µM 1.22096492462021 0.086945494041147 no 324 0.111049650226774 129 2994293 SGTC_2221 6807166 181.081 µM 1.21990988212426 0.0871249795782387 no 325 0.111249519613602 111 674925 SGTC_1698 5-fluorocytosine 1.055 µM 1.21966557350721 0.0871665811833881 no 326 0.111295838633219 136 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_606 k015-0008 38.6 µM 1.21827885365221 0.0874029970968218 no 327 0.1115590115509 142 1970475 SGTC_2999 9069765 71.4286 µM 1.2166776341535 0.0876765771533506 no 328 0.11186344596823 123 2097066 SGTC_1670 st016595 4.04 µM 1.21504824239905 0.0879556259803867 no 329 0.112173846109912 151 597879 SGTC_1610 st001799 48.1 µM 1.21118448130783 0.0886199782444597 no 330 0.112912354505619 123 621897 SGTC_456 gingerol 170 µM 1.21105587621265 0.0886421552759685 no 331 0.112936995262478 142 442793 A herb. SGTC_1907 st060210 83.7 µM 1.20715752320666 0.089316361678162 no 332 0.113685742672551 150 688793 SGTC_1390 3413-2614 145 µM 1.20450177694352 0.0897778435409505 no 333 0.114197847835483 168 3421432 SGTC_487 nimodipine 119 µM 1.20403893968848 0.08985845056456 no 334 0.114287264173214 107 4497 L-type voltage-gated calcium channels inhibitor SGTC_2106 5357045 167.29 µM 1.19845691807061 0.09083484697547 no 335 0.115369592692393 147 668842 SGTC_416 estradiol valerate 100 µM 1.19766817116594 0.090973445408075 no 336 0.115523112567347 154 13791 A steroid. SGTC_833 3852-0053 558 µM 1.19486707150285 0.0914669218844163 no 337 0.116069484999111 156 3123681 SGTC_900 1112-0045 141 µM 1.19479506005791 0.0914796344209242 no 338 0.116083555435592 139 56211 YIL048W NEO1 SGTC_323 4013-0906 34.3 µM 1.19336817762409 0.0917317991474339 no 339 0.116362606076457 134 2910086 SGTC_3298 9116858 71.43 µM 1.19025108330675 0.0922844558596079 no 340 0.116973860377773 161 2506942 SGTC_1744 st037937 38.9 µM 1.1891932816017 0.0924725616331276 no 341 0.117181808829545 143 1016152 SGTC_234 nsc-17383 10.7 µM 1.18787017232796 0.0927082454203662 no 342 0.117442281363566 148 408974 SGTC_865 0488-0499 301 µM 1.18721689769366 0.0928247761006896 no 343 0.117571038667096 131 9634651 SGTC_2553 4-methylesculetin 85.09 µM 1.18638465074811 0.0929733885738673 no 344 0.117735215261899 131 5319502 SGTC_1974 st069448 26.9 µM 1.18508348510516 0.0932060871510244 no 345 0.117992220032053 128 6323587 YNR016C ACC1 SGTC_776 4476-4378 112 µM 1.18283857682321 0.0936085746131218 no 346 0.118436564297544 145 2892008 SGTC_1379 2144-0755 36.5 µM 1.17954912355654 0.0942006535041944 no 347 0.119089794004208 158 5392327 SGTC_1272 0839-0021 27 µM 1.17683841980787 0.0946906339950905 no 348 0.119630002338732 155 5027250 SGTC_19 0279-0214 38.434 µM 1.17466685204429 0.0950845146916186 no 349 0.12006401298695 155 3566274 YBR002C RER2 SGTC_1973 st070275 50.2 µM 1.17304979083906 0.0953786014706478 no 350 0.120387919695749 115 17118334 SGTC_2374 9071832 200 µM 1.16849127587071 0.0962112390906806 no 351 0.121304328127519 128 17381698 SGTC_1227 3909-8010 46.6 µM 1.16503959457984 0.0968452531841414 no 352 0.122001482995122 125 15982272 SGTC_26 0302-0163 425.158 µM 1.1633803135473 0.0971511239444962 no 353 0.122337616619864 180 3100915 SGTC_1048 3161-0300 24.5 µM 1.16268229822823 0.0972800072583861 no 354 0.122479213141232 134 2165101 SGTC_1700 st030840 7.9285 µM 1.16150165865335 0.0974982890067839 no 355 0.122718974523259 173 5499307 SGTC_516 3992-2719 87.3 µM 1.16132003529648 0.0975319001747189 no 356 0.122755887345045 110 5350887 YDR037W KRS1 SGTC_1757 st041620 31.8375 µM 1.15816758062965 0.0981166469948886 no 357 0.123397827733988 126 5289815 SGTC_2799 7812892 81.82 µM 1.15490018843856 0.0987254199134653 no 358 0.124065651125464 183 20205235 SGTC_2112 5488546 200 µM 1.15372566484403 0.0989449284968909 no 359 0.124306329190921 165 600757 SGTC_1321 1326-2144 215 µM 1.15001666078062 0.0996404539496843 no 360 0.125068504611024 156 3513030 SGTC_1403 3909-7815 62.9 µM 1.14812836920347 0.0999959223392736 no 361 0.125457787174377 142 6615483 SGTC_2204 7233102 200 µM 1.1478218933127 0.100053703258507 no 362 0.125521048685781 129 2172480 SGTC_1010 4112-3296 15.2 µM 1.14391598453531 0.100792233464294 no 363 0.126329240650059 135 704384 SGTC_2176 5809774 33.9695 µM 1.13958588766966 0.101615606617822 no 364 0.127229433749726 126 2870539 SGTC_402 epigallocatechin gallate 10 µM 1.13761222844396 0.101992521023579 no 365 0.127641219084363 175 65064 An antioxidant. SGTC_275 trichlorophene 5.69 µM 1.13451608040575 0.102585847926765 no 366 0.128289066209762 142 62616 SGTC_514 4466-0038 2.65 nM 1.1328418001777 0.102907740126418 no 367 0.128640347102483 173 5722064 SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM 1.13111238301923 0.103241002596892 no 368 0.129003896492781 158 756377 SGTC_3226 9131256 49.47 µM 1.13092673137431 0.10327682459924 no 369 0.129042965554319 141 17178073 SGTC_1183 1254-0324 198 µM 1.1222617544866 0.10495880932248 no 370 0.130875581217978 138 5799357 SGTC_2518 prenyletin 46.28 µM 1.12002652142507 0.105395896928168 no 371 0.131351230229247 117 3873459 A coumarin with calcium channel inhibitory activity. SGTC_2360 9040895 200 µM 1.1188131356893 0.105633718518178 no 372 0.131609933301767 140 4914414 SGTC_3045 9092950 49.47 µM 1.11750508770788 0.105890528092403 no 373 0.131889212725527 137 44120432 SGTC_3075 9116269 49.47 µM 1.11592676278715 0.106201001580865 no 374 0.132226742474141 144 17015205 YNL244C SUI1 SGTC_3303 9125618 40.5795 µM 1.11496419829678 0.106390670868832 no 375 0.132432881996615 152 22695467 SGTC_297 0986-0032 24 µM 1.11403078179282 0.10657483015559 no 376 0.132632990685395 182 2847425 SGTC_1015 4130-4525 82 µM 1.11132453647923 0.107110061831112 no 377 0.13321434081783 171 1363237 SGTC_3215 9129942 49.47 µM 1.11095956000703 0.107182393681294 no 378 0.133292878303415 169 17682944 SGTC_1894 3',6'-dihydroxyflavone 78.7 µM 1.10983074233104 0.107406328199607 no 379 0.133535984614733 165 688662 SGTC_2474 5321570 43.32 µM 1.10977437243493 0.107417519677222 no 380 0.133548132630775 157 2841384 SGTC_451 chloral hydrate 100 µM 1.10939145341212 0.107493565299121 no 381 0.133630673857468 178 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1 SGTC_1160 4092-0570 10.5 µM 1.10587787095045 0.108193155427108 no 382 0.134389692053927 164 4994975 SGTC_1917 st066507 28.5 µM 1.10502420109373 0.108363623574343 no 383 0.134574551356929 175 3156428 SGTC_484 loperamide 105 µM 1.10499123910773 0.108370209580739 no 384 0.134581692660939 116 3955 An opioid-receptor agonist. SGTC_1066 ketoconazole 628 nM 1.10421471692732 0.108525446789034 no 385 0.134750003551712 167 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W SGTC_919 tnp00227 403.569 nM 1.10344261427964 0.108679959018096 no 386 0.134917499659721 157 1269246 A methoxyflavone. YNL221C POP1 SGTC_2130 NSC 7 2.4545 µM 1.09957319206159 0.109456686395808 no 387 0.135759063812307 163 21448 SGTC_2411 st077133 39.94 µM 1.09932680717065 0.109506279068464 no 388 0.135812771772608 176 1403142 YNL221C POP1 SGTC_1115 galangin 695.678 nM 1.09918848411989 0.109534127984212 no 389 0.135842930359193 183 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_2902 5787006 60.46 µM 1.09851489980163 0.109669815036461 no 390 0.135989857545442 156 591003 SGTC_262 fenpropimorph 62.5 µM 1.09771315563331 0.109831475897604 no 391 0.136164881671607 167 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_2586 curcumin 80 µM 1.09326178840064 0.110732145166461 no 392 0.137139437496114 163 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40 SGTC_2181 6316240 54.2555 µM 1.09221378671661 0.11094496058262 no 393 0.137369572016979 147 12779990 SGTC_2045 5106652 78.05 µM 1.09109232420491 0.111173017859396 no 394 0.137616130003824 139 673349 SGTC_2746 daunorubicin 9.88 µM 1.08790750895077 0.111822502066737 no 395 0.138317970435625 123 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_793 0488-0545 106 µM 1.08596917494197 0.112219115439787 no 396 0.138746315090688 173 292548 SGTC_2567 aureobasidin a 60 nM 1.08417233467623 0.112587674032066 no 397 0.139144197780497 194 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1 SGTC_905 2-aminofluorene 215 µM 1.08355681083243 0.112714125687908 no 398 0.139280674486397 158 1539 An established DNA mutagen. YPR165W RHO1 SGTC_157 1348-1695 65.819 µM 1.08258492198957 0.112913994492824 no 399 0.139496351431046 184 5380510 SGTC_100 0086-0128 49.5915 µM 1.08214056812978 0.113005460029155 no 400 0.139595035955344 172 93297 SGTC_3240 9133527 49.47 µM 1.08193115698407 0.113048583423363 no 401 0.139641559577504 155 17617455 SGTC_685 1278-0033 54.9 µM 1.08185028287264 0.113065240723916 no 402 0.139659529717078 178 3590572 SGTC_2747 doxorubicin 7.63 µM 1.076256590403 0.114221603148079 no 403 0.140906258490462 107 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_1524 corynanthine 62.1 µM 1.075888773172 0.114297934631968 no 404 0.140988501748681 159 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist. SGTC_2573 2',4'-dihydroxychalcone 15.04 µM 1.07558392610007 0.114361225719049 no 405 0.141056689664912 166 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_2063 5246145 200 µM 1.07421056287405 0.114646667126881 no 406 0.141364159613981 176 711240 SGTC_988 1497-1057 103 µM 1.07303408491028 0.114891590555858 no 407 0.141627911676854 171 3533044 SGTC_2583 asiatic acid 100 µM 1.07182082919599 0.115144560092388 no 408 0.141900257821777 202 5320556 A kinase inhibitor; arrests cells at G2/M. SGTC_2250 alverine citrate 130 µM 1.06869198516616 0.115798765644229 no 409 0.142604242106691 174 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1 SGTC_1119 parthenolide 318.541 nM 1.06687990191779 0.116178856441484 no 410 0.143013035755962 184 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs. SGTC_557 1315-0110 16.2 µM 1.06624942179994 0.116311309240867 no 411 0.143155453272537 152 6833801 SGTC_759 3486-0358 89.3 µM 1.0656488346059 0.116437581670797 no 412 0.143291207422674 182 875103 SGTC_352 k048-0007 5.11 µM 1.06304386661059 0.116986397264365 no 413 0.143881029304182 196 6811911 SGTC_2946 9065502 71.43 µM 1.06184044161791 0.117240553366878 no 414 0.144154063416276 122 16489101 SGTC_1759 st043059 70 µM 1.06168294134475 0.117273845396654 no 415 0.144189823050255 181 669426 SGTC_2182 6325192 200 µM 1.06093591677861 0.1174318408532 no 416 0.144359512616805 165 736248 SGTC_1618 st003135 44.5 µM 1.05766479814024 0.118125456275723 no 417 0.145104144659704 179 1270615 SGTC_1081 sertraline 6 µM 1.05666393496964 0.118338259296218 no 418 0.145332495061688 183 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1 SGTC_1797 st048695 56.8 µM 1.05590898692018 0.118498955183593 no 419 0.145504898941722 185 592262 YIL048W NEO1 SGTC_196 k015-0023 18.111 µM 1.05308860545561 0.119100656879346 no 420 0.146150192326974 149 5211998 SGTC_1261 0712-0010 12.7 µM 1.04804619473548 0.120181776328641 no 421 0.147308662051011 176 2840123 SGTC_3091 9116372 49.47 µM 1.04548805533268 0.120732891023834 no 422 0.147898729153412 165 17169793 SGTC_1493 4348-0038 111 µM 1.04514876239083 0.12080612026294 no 423 0.147977110035662 208 800424 SGTC_3096 9117468 49.47 µM 1.04501779302618 0.120834395604188 no 424 0.148007373021506 151 41316311 SGTC_1410 3909-8106 77.9 µM 1.04446620248939 0.120953531138183 no 425 0.148134874063473 188 1039210 SGTC_2750 bromebric acid 70.15 µM 1.04337415035894 0.121189642258819 no 426 0.148387520416703 170 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2 SGTC_2971 9092186 9.93 µM 1.04241378516852 0.121397549261412 no 427 0.148609939012923 155 25236400 SGTC_2467 5474540 200 µM 1.04229713082027 0.121422820532933 no 428 0.148636971092419 175 5413519 SGTC_2729 fluphenazine 10.66 µM 1.04165350170344 0.121562318834436 no 429 0.148786177083713 192 3372 An atypical antipsychotic. SGTC_1611 st001856 99.4 µM 1.0404732317946 0.121818419698262 no 430 0.149060047053924 193 647478 SGTC_1269 0831-0796 3.05 µM 1.03891644366979 0.122156798750522 no 431 0.149421799049021 182 927758 SGTC_2097 5376186 200 µM 1.0357859685881 0.122839226402473 no 432 0.150151002511226 165 742755 SGTC_726 3448-4391 34.2 µM 1.0355216137871 0.122896976576787 no 433 0.150212688956764 175 1356692 SGTC_3344 9148862 3.898 µM 1.0319861566671 0.123671152354434 no 434 0.151039301302474 178 4905352 SGTC_3027 9089541 49.47 µM 1.031641356514 0.123746837225986 no 435 0.151120079462782 187 9943819 SGTC_847 0342-0274 5.54 µM 1.03148698852097 0.123780732061397 no 436 0.151156253384436 192 18097 SGTC_2156 5649887 115 µM 1.03090045425529 0.123909577620289 no 437 0.151293751788823 178 54680440 YKL052C | YBR257W ASK1 | POP4 SGTC_116 0155-0182 31.788 µM 1.02978456639733 0.124154966815359 no 438 0.151555573630246 165 771486 SGTC_326 k292-0812 17.5 µM 1.02939184942865 0.124241408021469 no 439 0.151647788804722 172 3579357 SGTC_2773 thioridazine 9.09 µM 1.02904516649654 0.124317751620841 no 440 0.151729225560839 172 5452 An antipsychotic. SGTC_3235 9132602 49.47 µM 1.02828390827522 0.124485504606962 no 441 0.151908149129099 194 4912240 SGTC_365 0121-0052 13.6 µM 1.02816415618125 0.124511907912461 no 442 0.151936308011948 162 3101739 SGTC_1862 st057513 3.81 µM 1.02731427395549 0.124699405023907 no 443 0.152136251607263 173 5393163 SGTC_938 3126-1755 342 µM 1.02618285802595 0.12494931888838 no 444 0.152402699932462 167 1777771 SGTC_1638 st008370 60.6 µM 1.02521430888223 0.125163535567674 no 445 0.152631039054309 179 24207134 SGTC_2439 5492030 7.2 µM 1.02328461558865 0.125591095317467 no 446 0.153086647763834 176 5722370 SGTC_1924 st058459 75.1 µM 1.02291253019564 0.125673654878784 no 447 0.153174602252037 164 688683 SGTC_3149 9097855 49.47 µM 1.02002364320263 0.12631593914408 no 448 0.153858623881546 160 25236625 YMR079W SEC14 SGTC_2741 miltefosine 3.04 µM 1.01696833400125 0.126997709066295 no 449 0.154584246826239 140 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis. SGTC_2614 arthonioic acid 13.39 µM 1.0164452789488 0.127114681250913 no 450 0.154708696551769 163 6710684 SGTC_2626 ethyl orsellinate 100 µM 1.01582314308795 0.127253908728633 no 451 0.154856806604153 190 75653 A natural product. SGTC_671 0560-0003 407 µM 1.01362411885449 0.127746877310696 no 452 0.155381072221832 153 3238678 SGTC_515 4092-1064 102 µM 1.0124853063533 0.128002692827572 no 453 0.155653034364626 195 717353 SGTC_780 0109-0199 192 µM 1.01186795364653 0.12814151962975 no 454 0.155800596775453 193 610414 SGTC_3133 9127736 49.47 µM 1.01184589672977 0.128146481599204 no 455 0.15580587062461 168 27243420 SGTC_1935 st074532 41.6 µM 1.00846860439475 0.12890781927392 no 456 0.156614776225588 196 2829742 SGTC_1201 1889-3372 45.9 µM 1.00794410262011 0.12902633773955 no 457 0.156740648821604 179 5392199 SGTC_1368 1852-0141 284 µM 1.00523345603437 0.129640050210584 no 458 0.157392224443566 181 2838987 SGTC_1306 1185-0270 9.02 µM 1.0030096279045 0.130145050599022 no 459 0.157928107953706 185 1548076 SGTC_3316 9136639 10.545 µM 0.998924049828576 0.131076372644613 no 460 0.158915742434932 190 4903665 SGTC_3292 9120825 59.784 µM 0.998840771957724 0.131095403890098 no 461 0.158935915761991 189 24824900 SGTC_710 3448-4187 58 µM 0.996152149575882 0.131710852602618 no 462 0.159588112385572 190 3946412 SGTC_2029 5175081 200 µM 0.994032750138717 0.132197404450122 no 463 0.160103461733539 174 1380876 SGTC_619 1652-1634 108 µM 0.989393962215493 0.133266653877711 no 464 0.161235213728729 177 5400454 SGTC_3060 1327-0027 12.5 µM 0.988856851319969 0.133390842263841 no 465 0.161366592103103 185 16000455 YPR107C YTH1 SGTC_1508 1080-0625 72.9 µM 0.988102269751996 0.133565447697397 no 466 0.161551282136823 177 767111 SGTC_2921 7974240 10.71 µM 0.988005074948186 0.133587949385287 no 467 0.161575081377798 182 2979074 YDR527W RBA50 SGTC_2129 girgensonine 121.053 µM 0.985409159557274 0.134189897629571 no 468 0.162211566139507 210 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_1798 st045719 60.953 µM 0.983081417717685 0.134731243110051 no 469 0.162783684546214 193 3980186 SGTC_3095 9117207 49.47 µM 0.981072802922836 0.135199574547494 no 470 0.163278420573542 143 17015229 SGTC_1319 1306-0155 43.7 µM 0.976818923517812 0.1361950964624 no 471 0.164329402927081 191 3122360 SGTC_1533 dihydroergotamine mesylate 29.4 µM 0.97659122620265 0.136248524823897 no 472 0.164385782237066 235 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release. SGTC_2820 7989630 71.43 µM 0.974885653060431 0.136649187527694 no 473 0.164808491743336 140 2984098 SGTC_1762 st045503 25.4615 µM 0.974879724399608 0.136650581655676 no 474 0.164809962330416 179 4645554 SGTC_607 4491-0986 66.8 µM 0.973377195298604 0.13700421582256 no 475 0.165182934337374 171 698981 YDR232W HEM1 SGTC_1809 st050081 57.6 µM 0.972759892018013 0.137149684955914 no 476 0.165336325413664 212 5036894 SGTC_2807 7945238 51.95 µM 0.971924508858316 0.137346713143237 no 477 0.165544052946215 196 17148797 SGTC_2774 tamoxifen 10.92 µM 0.971771732173051 0.137382766982383 no 478 0.165582060858794 189 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  SGTC_2929 9013348 24.6 µM 0.970866785428227 0.137596458281688 no 479 0.165807309983382 171 2995952 SGTC_575 k072-0246 11.9 µM 0.969120795051245 0.138009391856586 no 480 0.166242461684134 186 6796779 SGTC_828 2074-0507 139 µM 0.967924173242768 0.138292885265713 no 481 0.166541120329857 187 X828 SGTC_2041 5107442 45.335 µM 0.966280867980688 0.138682849603129 no 482 0.166951828417518 212 793005 SGTC_457 grayanotoxin iii 135 µM 0.965893633648652 0.138774851141808 no 483 0.167048704164382 207 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity. SGTC_2111 5486399 200 µM 0.963910796385769 0.13924659723877 no 484 0.167545325269925 193 689674 SGTC_1113 artemisinin 1.17947 µM 0.963080222047596 0.139444526978919 no 485 0.167753633134131 223 2240 An anti-malaria and mitochondrial poison. SGTC_2571 chrysanthemic acid 100 µM 0.962829458343083 0.139504322733535 no 486 0.167816557378589 192 2743 An insecticide. SGTC_1742 st038235 28.8875 µM 0.957911150066471 0.14068064174136 no 487 0.169053781740808 208 564103 YBR002C RER2 SGTC_2808 7946468 45.46 µM 0.957617556306804 0.140751073272277 no 488 0.169127821499634 209 2970879 SGTC_3242 9133940 49.47 µM 0.956693047226245 0.140973014205507 no 489 0.169361104241168 170 17248444 SGTC_2066 5222451 176 µM 0.955991591149933 0.14114156653718 no 490 0.169538241416261 212 2281147 SGTC_566 0958-0068 16.5 µM 0.954854751113103 0.141415027029782 no 491 0.169825577495706 213 6815365 SGTC_91 0417-1751 58.384 µM 0.954627772514509 0.14146966843217 no 492 0.169882983664154 204 6795624 SGTC_220 paclitaxel 373.376 µM 0.953828019515559 0.141662309951865 no 493 0.170085351893272 173 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_1589 2',5'-dimethoxyflavone 47.2 µM 0.953617434667634 0.141713064386179 no 494 0.170138663634706 184 688667 SGTC_2363 9053361 176 µM 0.953094185507271 0.141839229414194 no 495 0.170271175948063 203 6469797 YMR079W SEC14 SGTC_2642 cholecalciferol 100 µM 0.952963681337031 0.141870708225401 no 496 0.170304236294616 174 9821465 A vitamin D precursor, similar to steriods. SGTC_777 1315-0167 517 µM 0.952415094380386 0.142003084201919 no 497 0.170443253642919 196 4221767 SGTC_253 dyclonine 31.25 µM 0.951938104447927 0.142118251501913 no 498 0.170564186647654 180 3180 An oral anasthetic. SGTC_1531 st059297 52.4 µM 0.951372808635705 0.142254821736255 no 499 0.170707579282673 199 7566702 SGTC_1877 wortmannin 25 µM 0.950656828818725 0.142427923256718 no 500 0.17088930506312 195 312145 A covalent inhibitor of PI 3-kinase. SGTC_1148 3909-7663 27.7 µM 0.949852700784559 0.142622506065985 no 501 0.171093551626521 181 4084526 SGTC_1498 4478-3555 97.6 µM 0.94984928332489 0.142623333405889 no 502 0.171094419986004 177 3437919 SGTC_2030 5175110 200 µM 0.946766965051053 0.143370859849753 no 503 0.171878769364467 189 2831986 SGTC_1786 berberine 21.6 µM 0.946483489557468 0.143439741165906 no 504 0.171951019736991 211 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_1260 0700-1617 7.75 µM 0.945100355974945 0.143776147299112 no 505 0.172303821807801 203 2853078 SGTC_628 1636-0253 16 µM 0.944277265417883 0.143976592062854 no 506 0.172513990229366 218 4456143 SGTC_2645 abamectin 100 µM 0.943557980005201 0.144151911722836 no 507 0.17269778678353 188 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels. SGTC_504 lovastatin 124 µM 0.943368255721182 0.144198179372949 no 508 0.172746287182338 195 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1 SGTC_2863 9028737 58.44 µM 0.942011313690771 0.144529385741232 no 509 0.173093423789533 190 6460917 SGTC_1291 0993-0025 5.79 µM 0.939176374240729 0.145222998912249 no 510 0.173820098470902 199 4353356 SGTC_1534 6-azauridine 81.6 µM 0.938648633964528 0.145352365867476 no 511 0.173955587054352 216 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1 SGTC_529 4076-0302 30.3 µM 0.934225332928258 0.146439713795128 no 512 0.175093835366742 201 5816522 SGTC_882 0843-0131 351 µM 0.931184999156087 0.147190255629795 no 513 0.17587893806511 224 5425421 SGTC_3071 9117417 49.47 µM 0.930715581077691 0.147306366355736 no 514 0.17600035386782 192 45595590 YGL055W OLE1 SGTC_1644 st010134 20.9 µM 0.928703129326176 0.147804842577382 no 515 0.176521479284581 216 3818134 SGTC_1737 st035557 69.7 µM 0.926575169583593 0.148333156857375 no 516 0.177073575965207 200 5716916 SGTC_2452 5863136 48.41 µM 0.925575915458176 0.148581679683748 no 517 0.177333207287034 209 2184096 SGTC_469 w7 172 µM 0.925000737345062 0.148724857441313 no 518 0.177482761951723 184 45115570 A P450 inhibitor. SGTC_2791 5663188 71.43 µM 0.92371333064794 0.149045662726564 no 519 0.177817794824683 225 54690634 SGTC_327 1273-0057 3.96 µM 0.922319793630851 0.149393434936014 no 520 0.178180896204497 202 3108138 SGTC_329 k048-0121 21.3 µM 0.919982837187871 0.149977862660465 no 521 0.178790864057476 197 6832902 SGTC_935 2996-0153 430 µM 0.91832599705857 0.150393128756406 no 522 0.179224110431167 214 23738523 SGTC_2604 4'-hydroxychalcone 11.32 µM 0.918215314999369 0.150420897091265 no 523 0.179253076141486 209 5282362 SGTC_3259 9138485 49.47 µM 0.916530081518138 0.150844116802058 no 524 0.179694468645777 179 17646153 SGTC_2707 st078556 66.6 µM 0.914803469109657 0.151278549523765 no 525 0.180147406644273 183 17250899 SGTC_2752 diclazuril 33.15 µM 0.913733388012644 0.151548209788577 no 526 0.180428477781706 195 456389 An antifungal agent for coccidioides. YHR062C RPP1 SGTC_2910 7948405 25.97 µM 0.912259483557382 0.15192015636564 no 527 0.180816068702842 185 2971328 SGTC_3343 9148379 18.9835 µM 0.910927942734279 0.152256697800449 no 528 0.181166670805455 200 1955036 SGTC_1960 st011366 51.8 µM 0.908783283391811 0.152799791416138 no 529 0.181732266113798 232 3972846 SGTC_2861 9024595 19.48 µM 0.907124811323543 0.15322064729918 no 530 0.182170399407366 172 16482810 SGTC_334 1502-1024 68.5 µM 0.906646893234321 0.153342066805442 no 531 0.18229677771459 190 3296216 SGTC_634 1611-4317 11.2 µM 0.905162651209196 0.153719558498265 no 532 0.182689612536213 219 2843522 SGTC_1054 3429-0080 167 µM 0.90461963435904 0.153857819171832 no 533 0.182833464943631 206 1162877 SGTC_1553 gossypol 38.6 µM 0.903419649613238 0.154163646073116 no 534 0.183151607579647 196 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_3272 9137413 49.47 µM 0.900359949367412 0.154945256720998 no 535 0.1839643636435 215 17614870 SGTC_1871 st057448 67.3 µM 0.899781107618673 0.155093417664132 no 536 0.184118375117786 219 691747 SGTC_1096 rimcazole 32.2 µM 0.899435824290874 0.1551818412743 no 537 0.184210282291824 203 18528119 A dopamine reuptake inhibitor. SGTC_2699 st077704 54.6 µM 0.897813227300061 0.155597817735311 no 538 0.18464256580432 195 645852 SGTC_3017 9080681 49.47 µM 0.897348227002229 0.155717162826214 no 539 0.18476656485754 211 16451914 SGTC_1249 0481-0015 10.2 µM 0.896616995816572 0.155904959728131 no 540 0.184961662902926 226 4227577 SGTC_2555 cholic acid 100 µM 0.894364222331867 0.156484461659181 no 541 0.185563524254271 177 6708657 Influences liver metabolism. SGTC_2192 5915882 198.485 µM 0.893176032509348 0.156790681409202 no 542 0.185881455517183 198 2876149 SGTC_373 0844-0104 25.9 µM 0.891937960332142 0.157110176058138 no 543 0.186213093251305 215 5375804 SGTC_363 0455-0021 3.06 µM 0.891710896192785 0.157168818247454 no 544 0.186273955834639 215 4597466 SGTC_2785 7756463 72.73 µM 0.890933293063322 0.15736975313864 no 545 0.186482479012755 259 2201551 SGTC_3336 9143619 71.43 µM 0.890354139874849 0.157519517662904 no 546 0.186637879467756 203 45595730 SGTC_848 0368-0089 85.6 µM 0.889352819554939 0.157778672214515 no 547 0.186906746399171 214 762535 SGTC_779 1360-0071 233 µM 0.888872135123324 0.1579031789435 no 548 0.187035901233866 225 7566 SGTC_199 4063-0024 41.6 µM 0.888578468740215 0.157979276055899 no 549 0.187114833453635 200 306215 SGTC_1761 st044296 37 µM 0.885839141107752 0.158690271522578 no 550 0.187852107341244 223 1826700 SGTC_3114 9122766 49.47 µM 0.885022771064863 0.158902566406503 no 551 0.188072175037198 178 17176985 SGTC_2344 7990960 76.95 µM 0.884092683949937 0.159144659834523 no 552 0.188323091113543 229 140813 SGTC_303 1348-1668 34.2 µM 0.882225818278147 0.159631317201851 no 553 0.18882735135943 213 5380509 SGTC_1098 clofazimine 15.1 µM 0.882151447784491 0.159650724364854 no 554 0.188847456838071 224 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2 SGTC_2933 9026794 32.47 µM 0.879237292189931 0.160412395950573 no 555 0.1896363141688 210 17586027 SGTC_700 3453-2283 142 µM 0.879016418847714 0.160470222164008 no 556 0.189696186763169 216 565664 SGTC_1721 st082152 9.2685 µM 0.877869892350544 0.160770609769115 no 557 0.19000716485918 208 5296051 SGTC_1529 apigenin 74 µM 0.875798133709295 0.161314336846937 no 558 0.190569892413317 212 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_961 1252-1571 372 µM 0.874793830291532 0.161578344520042 no 559 0.190843047411351 223 6813498 SGTC_911 3456-4043 236 µM 0.871113189730006 0.162548304438175 no 560 0.191846176516637 213 914281 SGTC_1630 st005209 31.3 µM 0.870733919420033 0.162648468486005 no 561 0.191949726737027 226 3367314 SGTC_2358 9037157 4 µM 0.868500967606235 0.163238997648358 no 562 0.19256007141265 233 2388925 SGTC_2003 4023581 200 µM 0.867323802971499 0.163550872142741 no 563 0.19288230911277 192 16641307 SGTC_1070 indatraline 8.81 µM 0.865272887001651 0.164095159384921 no 564 0.19344451425143 229 10314472 A monamine transport inhibitor. YGL099W LSG1 SGTC_2831 7999036 19.48 µM 0.862787504418433 0.164756321415455 no 565 0.194127155317369 217 2988270 SGTC_2296 7971656 126.45 µM 0.861785849509526 0.165023269092689 no 566 0.194402686585882 205 666570 SGTC_3018 9082602 49.47 µM 0.861454514121682 0.165111633775502 no 567 0.194493881389306 225 17332089 SGTC_2011 4012611 177 µM 0.859434551574957 0.165651005185996 no 568 0.195050407046709 202 2049887 SGTC_3199 9111318 49.47 µM 0.858428023672655 0.165920193608444 no 569 0.195328079430758 202 8548020 SGTC_3203 9113543 49.47 µM 0.858260816281694 0.165964939353808 no 570 0.195374230438587 215 17018012 SGTC_3349 9149703 23.001 µM 0.85559236765309 0.166680088053016 no 571 0.196111646554427 193 4910494 SGTC_1162 k048-0130 20.1 µM 0.854073137990955 0.167088131191809 no 572 0.196532233240178 218 6797406 SGTC_1345 1488-0192 31.4 µM 0.85042565920896 0.168070418373536 no 573 0.197544237702884 208 658348 SGTC_663 1486-0733 13.9 µM 0.848222182901895 0.168665624185042 no 574 0.198157122742366 225 722445 YPR165W RHO1 SGTC_505 gw-5074 63.9 µM 0.848011836890636 0.168722513869363 no 575 0.198215689313919 232 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases. SGTC_3002 9075603 71.4286 µM 0.846695057163721 0.169078927183935 no 576 0.198582557254515 240 20105405 SGTC_56 0957-0365 83.25 µM 0.846293251501735 0.169187780299182 no 577 0.198694585813762 202 6752360 SGTC_2763 lisinopril 49.32 µM 0.845714420391436 0.169344670432996 no 578 0.198856038310342 229 5362119 A lysine-analog of enalapril and an ACE inhibitor. SGTC_3313 9133968 57.047 µM 0.839549711642216 0.171021383343117 no 579 0.200580452687199 223 1494643 SGTC_2174 5790901 200 µM 0.838463653134144 0.171317872311926 no 580 0.20088517646496 227 786020 SGTC_1990 st072050 59.8 µM 0.838172825021217 0.17139732279133 no 581 0.200966823470646 242 17233948 SGTC_2469 5655019 90.81 µM 0.836173029169307 0.171944278761299 no 582 0.201528784521131 224 2788239 SGTC_2461 5755302 26.15 µM 0.835902427832035 0.172018375331252 no 583 0.201604898244482 240 2788904 SGTC_2760 etidronate 98.04 µM 0.834357836227906 0.17244170848355 no 584 0.20203968473687 225 3305 A chelator and antioxidant. SGTC_3119 9125183 49.47 µM 0.833871273111979 0.172575200533892 no 585 0.202176763345451 186 22695334 SGTC_2432 5630864 12.22 µM 0.832583590849275 0.172928803171715 no 586 0.202539808295072 233 5714970 SGTC_1171 0368-0077 21.4 µM 0.82973485844927 0.173712715408642 no 587 0.203344354128625 235 3239779 SGTC_897 1000-0139 31.4 µM 0.828733935583489 0.173988684532177 no 588 0.203627489274338 229 6151020 SGTC_2463 5473429 200 µM 0.827051273588795 0.174453246947635 no 589 0.204104000216449 222 5399405 SGTC_1132 3456-3614 2.5 µM 0.825845966283007 0.174786501435319 no 590 0.204445737623285 208 3125502 SGTC_2884 9058502 51.95 µM 0.825344739538376 0.174925204113775 no 591 0.20458794923944 220 6471554 SGTC_3040 9091894 49.47 µM 0.824579389984869 0.175137131261781 no 592 0.204805213177095 205 25236966 SGTC_2976 9009005 19.48 µM 0.823950954379614 0.175311268317288 no 593 0.204983713157142 210 2993148 SGTC_936 3005-4620 401 µM 0.823274234422419 0.175498907495087 no 594 0.205176031136105 230 777207 SGTC_459 nigericin 15.3 µM 0.822890013915435 0.175605499806646 no 595 0.205285270994241 240 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification. SGTC_2744 captopril 92.04 µM 0.821076337049383 0.176109212548644 no 596 0.205801393800289 184 44093 angiotensin-converting enzyme (ACE) inhibitor  SGTC_655 k060-0012 42 µM 0.82021265825505 0.176349403348253 no 597 0.206047443536385 243 5994525 SGTC_124 0136-0217 7.121 µM 0.818168883190451 0.176918606375158 no 598 0.206630380204089 245 3976905 SGTC_2087 5276107 200 µM 0.816455428916325 0.177396706873613 no 599 0.20711985281209 239 144405 SGTC_2798 7813637 45.45 µM 0.815422535624622 0.17768530597112 no 600 0.20741524455129 240 956368 SGTC_2962 9082311 13.18 µM 0.812381935202016 0.17853659376432 no 601 0.20828625432208 249 16459453 SGTC_184 1494-0393 24.714 µM 0.811901845768269 0.178671240562694 no 602 0.208423977628332 247 3090647 SGTC_2486 5283202 22.39 µM 0.811773880557553 0.178707140719825 no 603 0.208460696085334 228 1377751 SGTC_987 1497-1013 404 µM 0.811603954451107 0.178754819867136 no 604 0.208509460736624 223 1676435 SGTC_2186 6124449 200 µM 0.811357299008761 0.178824042557362 no 605 0.208580256804072 237 3834182 YLR033W RSC58 SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM 0.810595390503652 0.17903797514134 no 606 0.20879903241985 210 803109 SGTC_3247 9135149 49.47 µM 0.810072009780189 0.179185025930888 no 607 0.208949395104003 252 8934436 YOR116C RPO31 SGTC_939 1165-0479 45.3 µM 0.810051854162165 0.1791906904391 no 608 0.208955186911159 240 1377347 SGTC_378 3970-0959 8.33 µM 0.808305173635831 0.179682002980087 no 609 0.209457462480893 240 6615653 SGTC_177 1327-0068 8.361 µM 0.808053137943593 0.179752966295111 no 610 0.209529996480012 245 15389900 YOR207C | YLR033W RET1 | RSC58 SGTC_2576 guaiol 23.12 µM 0.807437156379014 0.179926476510031 no 611 0.209707333570138 224 227829 SGTC_1558 st069300 45.6 µM 0.807013767015221 0.180045798161931 no 612 0.209829275778266 232 24208000 SGTC_18 0111-0177 500 nM 0.806493244211867 0.180192562502784 no 613 0.209979250918865 237 721752 SGTC_1913 st060213 96.1 µM 0.80600831870542 0.180329357527935 no 614 0.210119026282187 243 688959 SGTC_2014 4013930 200 µM 0.805892910418376 0.180361923217387 no 615 0.210152299720586 241 64556 SGTC_665 3914-0008 307 µM 0.805346326615646 0.180516207305995 no 616 0.210309927687678 230 1069549 SGTC_1211 1056-0033 32.3 µM 0.804661036638861 0.180709760874463 no 617 0.210507654841359 234 6741922 SGTC_2351 9026858 72.31 µM 0.803609386738349 0.181007042233143 no 618 0.210811300150776 250 1409300 SGTC_382 3229-0966 23.2 µM 0.803161646912479 0.181133702689531 no 619 0.210940655031085 232 5722370 SGTC_810 3825-7150 143 µM 0.802810197240124 0.181233162651447 no 620 0.211042223667501 205 22330411 YGL099W LSG1 SGTC_1617 st002906 78 µM 0.802606488176518 0.181290827800564 no 621 0.211101108523367 239 5150859 SGTC_2608 thymoquinone 42.66 µM 0.801254417186564 0.181673857819164 no 622 0.211492186894166 239 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC). SGTC_1527 coumarin 137 µM 0.799974922496925 0.182036793558129 no 623 0.211862663397074 251 323 A hepatotoxic, DNA x-linker. SGTC_626 0214-0009 33 µM 0.798368039450789 0.182493236473577 no 624 0.212328472306887 246 3437874 SGTC_2566 crystal violet carbinol 226 nM 0.797329025922733 0.18278875352702 no 625 0.212629983554556 269 68050 Cationic dye that binds acidic phospholipids including cardiolipin. SGTC_346 4513-0042 7.16 µM 0.796783514134985 0.182944027946616 no 626 0.212788385621406 227 2827372 SGTC_2241 6772625 37.8075 µM 0.796235559228094 0.183100080614095 no 627 0.212947566433337 235 2285411 SGTC_1004 4084-0029 199 µM 0.795734568347954 0.183242830992514 no 628 0.213093164993931 230 716894 YLR208W SEC13 SGTC_1671 st016596 74.5 µM 0.793946560871698 0.183752864499557 no 629 0.213613271075218 251 2829167 SGTC_2949 9072542 2.23 µM 0.793788264173072 0.183798061594338 no 630 0.213659352956574 243 16457352 SGTC_1849 st056239 19.2 µM 0.793399310566012 0.183909145580673 no 631 0.213772606153085 244 5393181 SGTC_185 k048-0037 25.491 µM 0.792014723494349 0.184304918729607 no 632 0.214176045621708 227 6827589 SGTC_2278 7948257 134.34 µM 0.79151234140018 0.184448651569371 no 633 0.214322538628359 233 1247028 SGTC_1106 tegaserod maleate 11.7 µM 0.79079604401193 0.184653706682372 no 634 0.214531509402998 248 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation. SGTC_837 0091-0265 12.5 µM 0.790303450360211 0.184794804141738 no 635 0.214675286132956 243 759367 SGTC_1369 1866-0067 208 µM 0.790105884307597 0.184851413358631 no 636 0.214732966838797 237 3531355 SGTC_2488 5268135 45.7 µM 0.788348397510531 0.185355465800554 no 637 0.215246472877714 246 1270356 YLR208W SEC13 SGTC_552 k242-0005 476 µM 0.786339695795943 0.185932611325836 no 638 0.215834251249559 262 4088318 SGTC_2084 5306078 60.6385 µM 0.784479401552855 0.186468108734763 no 639 0.216379431939766 259 679340 SGTC_2308 7584454 197.62 µM 0.784019479776592 0.186600647243932 no 640 0.216514340105647 241 893577 SGTC_2588 indole-3-carbinol 100 µM 0.782843623662273 0.186939766109511 no 641 0.21685947340441 238 3712 Induces cell cycle arrest. SGTC_72 0744-0168 198.391 µM 0.781418012938316 0.187351425681668 no 642 0.217278340093382 259 677577 SGTC_1958 st076513 41.9 µM 0.780741351142126 0.187547014617639 no 643 0.217477317306277 253 732122 YGL099W LSG1 SGTC_532 1548-0774 215 µM 0.780731995580651 0.187549719724536 no 644 0.217480069112672 263 5932993 SGTC_1586 deoxycorticosterone acetate 53.7 µM 0.780345455191832 0.187661506735226 no 645 0.217593782083642 259 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE. SGTC_3042 9091578 49.47 µM 0.777504081820782 0.188484491282316 no 646 0.218430713588154 229 25236497 SGTC_134 0269-0018 6.916 µM 0.773648225899509 0.18960486715729 no 647 0.21956942245311 244 4378915 SGTC_2634 4'-methoxyflavone 100 µM 0.77263408026759 0.189900221266456 no 648 0.219869484604147 216 77793 From seeds of Psoralea corylifolia (Fabaceae) SGTC_152 4469-0003 551.229 µM 0.77258024624076 0.189915907489798 no 649 0.219885419418357 252 697280 SGTC_2329 6138490 200 µM 0.772386691533513 0.189972312273093 no 650 0.219942716879158 244 720019 SGTC_2716 st080858 38.6235 µM 0.771900288299024 0.190114103016278 no 651 0.220086743285305 241 5296050 SGTC_1805 st050013 60.3 µM 0.767190919808782 0.19149028531123 no 652 0.22148400540365 244 4037144 SGTC_1868 st057644 42.7 µM 0.76513216400545 0.192093812023719 no 653 0.222096424435057 245 688665 SGTC_2825 7998094 58.44 µM 0.763506311526572 0.192571254153113 no 654 0.222580749853034 237 2987815 SGTC_620 0109-0052 432 µM 0.763127787246235 0.192682514268764 no 655 0.222693594856345 266 493037 SGTC_2840 9008771 71.43 µM 0.761571160061713 0.193140468429995 no 656 0.223157996487835 199 2992978 SGTC_2786 7743617 45.45 µM 0.760629874501084 0.193417713384266 no 657 0.223439085393955 238 583674 SGTC_1708 st033234 31.827 µM 0.759135762646355 0.193858285309364 no 658 0.223885673948319 231 674664 SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM 0.758403586622019 0.194074406738988 no 659 0.224104705699792 260 688788 SGTC_1043 0916-0009 19.3 µM 0.757165779902292 0.194440112335077 no 660 0.224475274433858 248 3101130 SGTC_112 phenothiazine 287.218 µM 0.754667669145097 0.195179446762329 no 661 0.225224205044229 249 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.  SGTC_1688 st021091 57.6 µM 0.751259086196821 0.19619099380659 no 662 0.226248373458686 257 3656366 SGTC_2829 7992743 58.44 µM 0.751023037803988 0.196261162131138 no 663 0.226319395612694 238 16462845 SGTC_545 4218-0007 221 µM 0.750925523126573 0.196290154024053 no 664 0.226348739468611 258 2840508 SGTC_646 4092-0839 27.3 µM 0.750644644478607 0.19637367599941 no 665 0.226433272728292 262 877796 SGTC_39 0986-0283 58.349 µM 0.750414950959417 0.196441993591057 no 666 0.226502414556224 224 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2 SGTC_2927 9011802 47.9 µM 0.748537706227831 0.19700088099568 no 667 0.227067945170873 254 43912568 SGTC_2862 9027634 71.43 µM 0.747302788522782 0.197369061079598 no 668 0.227440404817905 250 5012562 SGTC_360 0957-0399 1.01 µM 0.746316571974785 0.197663391724381 no 669 0.227738101479158 262 6752301 YPR165W RHO1 SGTC_1037 k284-1091 78.7 µM 0.744666490447166 0.198156441901406 no 670 0.228236680742867 247 3334711 SGTC_1417 3966-0327 90.4 µM 0.744035074954288 0.198345307329753 no 671 0.228427627862414 254 651118 SGTC_3128 9127691 49.47 µM 0.739201235274873 0.199794774060391 no 672 0.229892405431859 252 41316314 SGTC_1925 st057770 10.1 µM 0.738380931622506 0.200041379728026 no 673 0.230141499323698 245 5989122 SGTC_488 nitrendipine 139 µM 0.738358891102778 0.200048008233267 no 674 0.23014819424329 252 4507 Dihydropyridine L-type calcium channel blocker. SGTC_561 1550-0330 72.9 µM 0.736940512212078 0.200474851644523 no 675 0.230579263066329 249 6812934 SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM 0.736564772794363 0.200588017308334 no 676 0.230693532041556 255 688761 SGTC_2310 7668677 200 µM 0.733935606319835 0.201380945596425 no 677 0.231493992439014 261 2197143 SGTC_2520 obtusaquinone 4.71 µM 0.732888322036572 0.201697317754847 no 678 0.231813273117834 259 5967872 SGTC_3195 9113082 49.47 µM 0.73270303851334 0.201753320685251 no 679 0.23186978516963 253 17018038 SGTC_1020 4335-0961 93.3 µM 0.732642926054358 0.201771491996204 no 680 0.231888121305335 266 669075 SGTC_563 tetrahydrosecaminediol 614 µM 0.731379179834352 0.20215373491032 no 681 0.232273789393495 258 334274 A psychoactive constituent of the cannabis plant. SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM 0.731097704802072 0.202238931087962 no 682 0.232359738074349 294 368090 SGTC_2736 butenafine 14.65 µM 0.730835890242133 0.20231819575924 no 683 0.232439699289187 262 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_3244 9134489 49.47 µM 0.730587152002881 0.202393518768146 no 684 0.232515681017738 273 16584271 SGTC_2691 st077356 60.2 µM 0.730163013827795 0.202521995122528 no 685 0.232645273771394 270 2839272 SGTC_2556 citropten 84.59 µM 0.728599804067755 0.202995930237588 no 686 0.233123249198854 231 2775 A potential DNA crosslinker. SGTC_1810 st050138 53 µM 0.726712263029161 0.20356907818744 no 687 0.233701119799073 281 3444541 SGTC_2431 5490079 200 µM 0.724739498414511 0.204169134384492 no 688 0.234305929314973 289 5722345 SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM 0.724171917652814 0.204341970483546 no 689 0.234480098381566 268 551469 SGTC_2804 7954240 19.48 µM 0.723949405263797 0.204409752308208 no 690 0.234548398556382 258 828705 SGTC_2628 lathosterol 100 µM 0.723474678553796 0.204554408502005 no 691 0.234694152691133 248 6710616 SGTC_147 4466-0538 29.23 µM 0.720904654592916 0.205338589453304 no 692 0.235484089441174 271 6742687 YHR072W ERG7 SGTC_1901 st060216 58.6 µM 0.719378647176645 0.205805057618786 no 693 0.235953824810989 255 688792 SGTC_1404 3909-7820 48.3 µM 0.719376627982382 0.205805675259971 no 694 0.235954446700975 256 23741373 SGTC_495 decylubiquinone 155 µM 0.719243542430507 0.205846386555694 no 695 0.235995437602814 270 2971 A Co-enzyme Q analog. A free radical scavenger. SGTC_3193 9111931 49.47 µM 0.719136489888527 0.20587913773765 no 696 0.236028413077287 298 17087244 SGTC_414 piperonyl butoxide 100 µM 0.718982550280873 0.205926238759828 no 697 0.236075835659679 253 5794 A potent inhibitor of cytochrome P450. SGTC_1886 st057356 49.9 µM 0.718976455359188 0.205928103759324 no 698 0.236077713367179 250 24207747 SGTC_1461 k072-0203 53.8 µM 0.717541702048635 0.206367406040178 no 699 0.236519957283875 266 5418714 SGTC_296 1222-0039 74.9 µM 0.712927732649482 0.20778390133973 no 700 0.237945238602251 253 5984176 SGTC_59 0330-0160 1.33 µM 0.710566196610649 0.208511112660077 no 701 0.238676548298802 281 4293482 SGTC_1340 1486-1359 257 µM 0.709589285408847 0.208812380938454 no 702 0.238979432938885 268 4309068 SGTC_1889 st059080 5.18 µM 0.709161861885183 0.208944274099105 no 703 0.23911201873996 256 176925 Isolated from Daphnopsis sellowiana. SGTC_3300 9124615 50.48 µM 0.708519802653411 0.209142491146312 no 704 0.23931125958236 248 24824903 SGTC_2220 6782180 200 µM 0.707094328389706 0.209582960282137 no 705 0.239753930151657 250 833803 SGTC_2738 aclarubicin 5.55 µM 0.705541649042876 0.21006335586014 no 706 0.240236611255115 231 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31 SGTC_2837 9008476 45.46 µM 0.705239812571292 0.210156818450351 no 707 0.240330504534276 274 2992805 SGTC_537 1334-0398 209 µM 0.704096471410355 0.21051107140646 no 708 0.240686348715546 265 5846986 SGTC_601 0986-0029 62.9 µM 0.70157813494727 0.211292588058934 no 709 0.241471145667611 267 24747981 SGTC_355 1311-2252 105 µM 0.701356681569712 0.211361393008791 no 710 0.241540224288257 282 5338538 SGTC_1124 fisetin 1.16336 µM 0.700098920126303 0.21175242486066 no 711 0.241932765093984 264 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster. SGTC_686 1319-0111 510 µM 0.699891378746715 0.211816989122798 no 712 0.241997570926077 317 4562600 SGTC_2828 7998861 71.43 µM 0.699807271644993 0.211843157367353 no 713 0.242023836469255 220 2988188 SGTC_2545 solidagenone 89.61 µM 0.699422236513096 0.211962977503951 no 714 0.242144097621084 224 6708572 An anti ulcer agent SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM 0.69907699731451 0.212070447133203 no 715 0.242251956528143 263 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_1782 st039423 80.636 µM 0.699003943039436 0.212093192307543 no 716 0.24227478332933 276 2068169 SGTC_1126 isoteolin 1.0172 µM 0.698833689912343 0.212146205515063 no 717 0.242327985756706 260 133323 SGTC_2013 4024628 200 µM 0.698658601885056 0.21220073228716 no 718 0.24238270564536 283 5230760 SGTC_1310 1188-0297 994 nM 0.698088033877221 0.212378478214133 no 719 0.242561070497557 260 1588352 SGTC_971 1315-0384 26.7 µM 0.697611738874271 0.21252692239008 no 720 0.242710019152126 282 6769120 SGTC_106 0092-0003 11.579 µM 0.696297956755704 0.212936695463409 no 721 0.243121126254292 260 1072148 SGTC_2377 9073351 62.6 µM 0.695283335177996 0.213253474649555 no 722 0.243438877911428 284 7337946 YHR072W ERG7 SGTC_945 3381-0768 11.3 µM 0.695191415033765 0.213282186986135 no 723 0.243467675860314 283 1126236 YIL048W NEO1 SGTC_2812 7970281 58.44 µM 0.694647414792758 0.213452157988809 no 724 0.243638145063459 281 2233435 SGTC_1013 4112-3890 241 µM 0.694212551595608 0.213588086260071 no 725 0.243774461163559 278 705171 SGTC_263 alizarin 107.927 µM 0.691867290340105 0.214322030150217 no 726 0.244510336898395 288 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. SGTC_372 0155-0182 15.9 µM 0.691672461125789 0.214383067408018 no 727 0.244571522508708 247 771486 SGTC_2680 butyl paraben 22.24 µM 0.690305437954292 0.21481162079855 no 728 0.245001064433257 303 7184 An antifungal and steroid mimetic. SGTC_525 k781-2675 26.7 µM 0.689488404934707 0.21506799309354 no 729 0.245257983746874 269 3651118 YDL195W SEC31 SGTC_649 1123-0311 367 µM 0.688804718726836 0.215282659687413 no 730 0.245473082882258 269 693629 YIL048W NEO1 SGTC_3011 9081274 71.4286 µM 0.688139027640608 0.215491795524898 no 731 0.245682617805902 278 6625322 SGTC_826 1683-5028 118 µM 0.686785634245451 0.215917345456733 no 732 0.246108911930737 272 722377 SGTC_2886 9058944 51.95 µM 0.684904465516155 0.216509652790058 no 733 0.246702103975626 232 4949929 SGTC_770 0389-1121 67.2 µM 0.684664539018933 0.216585263913121 no 734 0.246777815408148 277 6753108 SGTC_3173 9105693 49.47 µM 0.680567330695755 0.21787882570641 no 735 0.24807265223011 300 17096658 SGTC_1285 0929-0069 65.5 µM 0.679898025498094 0.218090559865539 no 736 0.248284515976954 268 1206237 SGTC_2547 epiafzelechin trimethyl ether 100 µM 0.67915966690426 0.218324276542392 no 737 0.248518349947105 247 6708630 An antioxidant. SGTC_2334 9017922 200 µM 0.678693572987435 0.218471886054015 no 738 0.248666019634321 286 3163164 SGTC_2049 5262831 67.185 µM 0.678374481907884 0.218572973666607 no 739 0.248767142253239 277 763417 SGTC_3089 9117425 49.47 µM 0.67731175098342 0.21890983948536 no 740 0.249104088365722 299 9401657 SGTC_1642 st009582 77.7 µM 0.675736851376329 0.219409602042683 no 741 0.249603867192146 292 6739311 SGTC_1502 4534-4282 27.7 µM 0.675545778853062 0.219470279605511 no 742 0.249664538380659 291 3278949 SGTC_1636 st007707 68.9 µM 0.674078335971387 0.219936606366085 no 743 0.250130755939788 298 403051 SGTC_2390 9097792 176.6 µM 0.673027359335494 0.220270936840663 no 744 0.250464942654423 264 4497149 SGTC_232 clozapine 119 µM 0.670738749482932 0.220999983163663 no 745 0.251193486484468 271 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_1245 0418-0076 17.2 µM 0.670732215229942 0.221002066652755 no 746 0.251195568166954 296 6790114 SGTC_1167 k781-0610 148 µM 0.670064266837691 0.221215105648697 no 747 0.251408411308386 268 4525169 SGTC_1570 verbenone 133 µM 0.668207444820347 0.221807947101256 no 748 0.252000591936411 285 29025 A natural terpanoid with antifungal properties. SGTC_1720 st037298 9.481 µM 0.667511256415038 0.222030458085991 no 749 0.252222811011608 298 597396 SGTC_580 1123-0028 41 µM 0.665846175209525 0.222563156527619 no 750 0.252754713574903 296 1677248 YPR107C YTH1 SGTC_1898 st060199 18.6 µM 0.665841989374419 0.222564496591801 no 751 0.25275605146461 274 688866 SGTC_2443 5493264 126.67 µM 0.665178342652297 0.222777016362369 no 752 0.252968215457909 289 5340055 SGTC_1179 1021-1431 9.29 µM 0.664391489951896 0.223029140187128 no 753 0.253219889061687 298 2840958 SGTC_1229 0139-0193 12.2 µM 0.664321209761872 0.223051667311234 no 754 0.253242374473926 285 3090752 SGTC_1767 st044992 70.3 µM 0.663715735705245 0.223245795420276 no 755 0.253436133045584 293 9600693 SGTC_2636 apigenin dimethyl ether 100 µM 0.661843164097386 0.223846790733139 no 756 0.254035869935223 296 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_3082 9117008 49.47 µM 0.66119275477717 0.224055752297994 no 757 0.25424435352659 291 41448529 SGTC_2607 solasodine 47.35 µM 0.661053694358341 0.224100443588283 no 758 0.25428893988798 292 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity. SGTC_58 0957-0393 9 µM 0.660053086059391 0.224422168718132 no 759 0.254609881574795 274 6997992 SGTC_66 0109-0187 42.4 µM 0.659596296301001 0.224569127224909 no 760 0.254756465830601 266 759417 SGTC_3187 9109394 49.47 µM 0.659548245575038 0.224584589288561 no 761 0.254771887920956 280 17098090 SGTC_2908 7930301 100 µM 0.657523757492666 0.225236590287359 no 762 0.255422100065705 279 2223178 SGTC_1388 3346-4487 254 µM 0.657455815783638 0.225258489982683 no 763 0.255443936179042 302 3345614 SGTC_2252 omeprazole 400 µM 0.656562104251217 0.225546672844283 no 764 0.255731261217627 270 4594 A proton pump inhibitor. SGTC_3004 9076122 71.4286 µM 0.655990237727039 0.225731184196014 no 765 0.255915202735151 296 44782551 SGTC_79 0052-0007 94.094 µM 0.65546646753411 0.225900252273786 no 766 0.256083734567685 273 2801472 SGTC_851 0394-0702 453 µM 0.655421349525244 0.225914819290332 no 767 0.256098254750279 298 762646 SGTC_1346 1488-2224 62.4 µM 0.655212613717142 0.22598221964603 no 768 0.256165437107307 283 3722427 SGTC_2782 7736369 71.43 µM 0.655125240356242 0.226010435696278 no 769 0.256193561260353 296 2950836 YOL077C BRX1 SGTC_707 0865-0008 204 µM 0.654437326857298 0.2262326576516 no 770 0.256415046354595 304 723043 SGTC_819 1013-0258 27.7 µM 0.654221614001613 0.226302366440097 no 771 0.256484519208793 288 5753198 SGTC_918 glabranin 770.725 nM 0.653903349807102 0.226405237407853 no 772 0.25658703782847 278 124049 Also referred to as licorice root. SGTC_1674 st016616 23.6 µM 0.653297149206258 0.226601249677665 no 773 0.256782364963942 280 625830 SGTC_3137 9097352 49.47 µM 0.652900106845906 0.226729683458352 no 774 0.256910340040452 316 44120435 SGTC_2536 dehydroabietamide 32.04 µM 0.652235229184758 0.226944847560912 no 775 0.257124718344674 278 3983547 SGTC_500 h-89 112 µM 0.651983777320087 0.227026251051214 no 776 0.257205818886449 300 449241 Protein kinase A inhibitor; also known to inhibit several other kinases. SGTC_226 1,3-diallylurea 8.28947 mM 0.651908570962676 0.227050601095987 no 777 0.257230077708014 282 74537 YKL182W FAS1 SGTC_3308 9128332 17.569 µM 0.650100168229586 0.227636562489686 no 778 0.257813760289618 262 17332805 YDL196W YDL196W SGTC_2661 dactinomycin 12.96 µM 0.64926792494013 0.227906513022798 no 779 0.258082607058048 280 45006140 An Actinomycin D Classic transcription inhibitor. SGTC_1946 st076057 65.1 µM 0.647356774346818 0.228527104431217 no 780 0.258700532416999 287 953009 SGTC_424 splitomicin 100 mM 0.646109639918581 0.228932586912664 no 781 0.259104176396133 302 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_548 1436-0017 110 µM 0.645273458351014 0.229204681682446 no 782 0.259374994783007 286 9677137 SGTC_270 tamoxifen 5.46 µM 0.643732518071495 0.22970658073857 no 783 0.259874449750197 307 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  YIL048W NEO1 SGTC_3265 9137266 49.47 µM 0.643595323813494 0.229751296047661 no 784 0.259918941675012 253 17224265 SGTC_824 1304-0008 100 µM 0.643273576241618 0.229856181377481 no 785 0.260023299416487 287 768245 SGTC_3086 9117350 49.47 µM 0.642739683061411 0.230030282420185 no 786 0.260196513529865 259 2679265 SGTC_2094 5332512 191.667 µM 0.641248263730384 0.230517020796683 no 787 0.260680698400576 290 755774 SGTC_3176 9106582 49.47 µM 0.640852495089802 0.230646280099152 no 788 0.260809261324915 258 17018027 SGTC_2594 a-mangostin 100 µM 0.639901097048148 0.230957175364767 no 789 0.261118450327786 298 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis. SGTC_2827 7993847 71.43 µM 0.638432280787305 0.23143761023359 no 790 0.261596161580505 270 2985692 SGTC_941 3237-0776 460 µM 0.638123295834471 0.231538746967646 no 791 0.261696711546326 290 760008 SGTC_1317 1273-0028 910 nM 0.637036000048476 0.231894835662794 no 792 0.262050697239007 289 5917803 YLR359W | YHR072W ADE13 | ERG7 SGTC_896 0964-0007 44.5 µM 0.634545690243696 0.232711558704335 no 793 0.26286237930145 292 6756758 SGTC_158 k038-0087 26.446 µM 0.633716415184318 0.232983882495647 no 794 0.2631329550932 290 X158 SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM 0.633432543981285 0.233077142974786 no 795 0.263225609246451 318 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis. SGTC_2708 st078559 56 µM 0.63329332832955 0.23312288720093 no 796 0.263271054634576 267 17250902 SGTC_1645 Cervolide 78 µM 0.633265289408886 0.233132100982994 no 797 0.26328020811054 310 23173 A fragrance. SGTC_380 3970-0968 6 µM 0.628800893662137 0.23460170818264 no 798 0.264739707451589 278 2891601 SGTC_192 3455-0609 60.9 µM 0.628494321442128 0.234702814479225 no 799 0.26484008272668 277 3769639 SGTC_2748 diazoxide 86.69 µM 0.62845927641353 0.234714373724294 no 800 0.264851558104597 249 3019 A potassium channel activatior. SGTC_2880 9042983 58.44 µM 0.627272340512407 0.235106058230846 no 801 0.265240365497444 307 6464714 SGTC_3352 9151559 45.5865 µM 0.626319452269668 0.235420768948381 no 802 0.265552714925812 276 17159339 SGTC_3132 9126706 49.47 µM 0.626044195748739 0.23551172127218 no 803 0.265642976613543 320 850858 SGTC_2533 agelasine 13.65 µM 0.623572711543072 0.236329235577552 no 804 0.266454118224716 296 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase. SGTC_2941 9056145 11.23 µM 0.621472435771463 0.237025188290585 no 805 0.267144412582271 293 2119517 SGTC_3314 9135860 59.4275 µM 0.619973991034813 0.237522404394687 no 806 0.267637455272189 299 25252478 SGTC_602 3130-1533 38.1 µM 0.619282669378728 0.237751992590715 no 807 0.26786507970125 312 720941 SGTC_584 0986-0246 15.4 µM 0.619043986422947 0.237831287554916 no 808 0.2679436910424 324 53315 YDR232W HEM1 SGTC_1996 st072960 66.8 µM 0.617568424259803 0.238321818878705 no 809 0.268429932074945 297 1719405 SGTC_2551 apiole 73.87 µM 0.617033810225342 0.238499680975212 no 810 0.268606212522767 287 10659 A possible DNA adduct former. SGTC_2037 5169046 200 µM 0.616902239426319 0.238543464737516 no 811 0.268649604813692 279 5718022 SGTC_1778 st046819 58.9 µM 0.616438854083618 0.238697703845099 no 812 0.268802458193684 308 671715 SGTC_3224 9130643 49.47 µM 0.616363219325213 0.238722884265261 no 813 0.268827411399222 293 17644395 SGTC_284 0988-0104 32.6 µM 0.615589460715865 0.238980568434138 no 814 0.269082754459722 303 4666532 SGTC_2711 st079103 59.1 µM 0.613697489271679 0.239611290142779 no 815 0.269707623898457 305 54693780 SGTC_1613 st002381 52.1 µM 0.610899380711754 0.240545751683638 no 816 0.27063309742741 296 551167 SGTC_1579 chlormadinone acetate 49.4 µM 0.610337058023768 0.240733785182587 no 817 0.27081927669553 325 45114258 A steroidal progestin. SGTC_2574 2',4'-dihydroxychalcone 14.64 µM 0.6099485542313 0.240863742580112 no 818 0.270947943644196 297 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_1631 benzylvanillin 81.9 µM 0.609344212265661 0.241065975285776 no 819 0.271148153742548 278 75506 SGTC_2309 7664088 163.95 µM 0.607569848966768 0.241660268722032 no 820 0.271736401572044 296 704922 SGTC_1652 st011932 78 µM 0.606917224958458 0.241879054164576 no 821 0.271952923163312 294 1551076 SGTC_93 0109-0045 59.227 µM 0.602787150724716 0.243266107481659 no 822 0.273325147892395 303 88733 SGTC_1169 aniline yellow 25.8 µM 0.602512323183111 0.243358558495059 no 823 0.27341658138869 307 6051 A DNA damaging agent. SGTC_518 1021-0119 62.6 µM 0.600432843878807 0.244058702922371 no 824 0.274108902252597 306 1097762 SGTC_130 0136-0219 337.655 µM 0.600400241497536 0.244069688532993 no 825 0.274119763452375 342 234244 SGTC_943 3253-1379 105 µM 0.599272184913913 0.24444995965173 no 826 0.274495696583605 319 668464 SGTC_866 0495-0101 262 µM 0.597726229560422 0.244971623738344 no 827 0.275011310418005 300 635694 SGTC_1772 st048439 82.2 µM 0.597620617609433 0.24500728306796 no 828 0.275046551984173 283 2927068 YDL195W SEC31 SGTC_370 0180-0345 38.7 µM 0.597466463274305 0.245059337495185 no 829 0.275097995611931 284 3989527 SGTC_1200 1643-0193 18.4 µM 0.596038176317025 0.245541920429653 no 830 0.275574861750543 316 5403974 SGTC_2048 5246248 200 µM 0.594794468628275 0.24596255403911 no 831 0.275990432716176 284 677046 SGTC_2629 bisabolol 100 µM 0.593215697339916 0.24649706573888 no 832 0.276518404339293 335 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer. SGTC_1440 4100-1550 40 µM 0.592817541941116 0.24663196416294 no 833 0.276651633343707 315 742806 SGTC_388 3',4'-dichloroisocoumarin 16.7 µM 0.592641784091448 0.246691524989385 no 834 0.276710454667151 303 1609 A potent and irreversible inhibitor of serine proteases. SGTC_2625 euphol 100 µM 0.591747551323911 0.246994681876701 no 835 0.277009824674342 299 6708538 A triterpene alcohol. SGTC_1251 0490-5699 265 µM 0.591216651309147 0.247174758351978 no 836 0.277187633618866 303 3883818 SGTC_1487 3970-0795 2.82 µM 0.591185537323781 0.247185314111536 no 837 0.277198056041504 296 3765103 SGTC_496 calpeptin 138 µM 0.590938692971309 0.247269067298104 no 838 0.277280749643847 288 73364 A calpain inhibitor. SGTC_2800 7887935 81.82 µM 0.590257860840142 0.247500149213706 no 839 0.277508892972118 316 2961002 SGTC_633 0437-0093 97.7 µM 0.589474251681691 0.247766257548942 no 840 0.277771589857806 310 2831118 SGTC_1273 0849-0096 14.1 µM 0.589275140629593 0.247833898638507 no 841 0.277838359126107 314 5286025 SGTC_1198 1612-1005 86.7 µM 0.589174831156688 0.247867979044359 no 842 0.2778719995542 316 6998509 SGTC_452 diindolylmethane 8 µM 0.586886594011666 0.248646092547202 no 843 0.278639936984621 313 3071 Inhibits expression of several cancer promoting factors. SGTC_1100 amiodarone 5.07 µM 0.586844389837646 0.248660456257636 no 844 0.27865411049903 286 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. SGTC_1329 1447-1697 50.6 µM 0.5859552217792 0.248963177199249 no 845 0.278952803214902 304 2840515 SGTC_1419 3993-2473 62.6 µM 0.585474079947182 0.249127065662703 no 846 0.279114495124195 308 704026 SGTC_2996 9066192 71.4286 µM 0.584131961925839 0.249584526426262 no 847 0.279565766278907 295 6472854 SGTC_979 1426-2828 121 µM 0.584085989133448 0.249600204147868 no 848 0.279581230353581 304 747872 SGTC_791 1348-1292 225 µM 0.583037379426797 0.249957944863103 no 849 0.279934068623745 312 5437054 SGTC_3254 9136651 49.47 µM 0.582792819398007 0.250041417382983 no 850 0.280016389707278 332 16454030 SGTC_1267 0828-0272 9.49 µM 0.582104290840144 0.250276503365334 no 851 0.280248217561771 303 745334 SGTC_751 0833-0568 350 µM 0.581070287239597 0.250629765761965 no 852 0.280596541563872 317 6954252 SGTC_813 k007-0158 173 µM 0.58106781569375 0.250630610470112 no 853 0.280597374402524 313 6523916 SGTC_3315 9136395 68.55 µM 0.580610487211665 0.250786939044103 no 854 0.280751501306208 332 16876844 SGTC_1863 st057641 20.1 µM 0.580545724357671 0.250809081099941 no 855 0.28077333071737 321 3921635 SGTC_3282 9108498 15.4605 µM 0.580108265047667 0.250958673083409 no 856 0.280920805242058 308 16459645 SGTC_1287 0971-0001 34.6 µM 0.579211341228098 0.251265529456712 no 857 0.281223289619491 303 4665869 SGTC_2768 sulfasalazine 50.2 µM 0.57917487855719 0.251278008293253 no 858 0.281235589851932 321 5384001 An antioxidant and salicylic acid derivative. SGTC_1423 4048-0112 5.59 µM 0.577818767044087 0.251742351024265 no 859 0.281693241742446 309 X1423 SGTC_1480 1070-0044 41.2 µM 0.576965390859331 0.252034785527095 no 860 0.281981417655881 305 3124987 SGTC_2119 5528445 120.635 µM 0.573847971959546 0.25310458241896 no 861 0.283035341459748 309 791935 SGTC_765 1319-0117 244 µM 0.572358651850537 0.25361651057633 no 862 0.283539511046838 298 3487746 YGL099W LSG1 SGTC_406 estrone 100 µM 0.572206413016919 0.253668870677115 no 863 0.283591071675931 328 5870 A steroid. SGTC_27 0485-0001 32.618 µM 0.571275775798538 0.253989071782321 no 864 0.283906359842631 317 2054479 SGTC_2843 9000894 45.46 µM 0.569018448657747 0.254766622655799 no 865 0.28467181005222 258 2242070 SGTC_1196 1588-0294 184 µM 0.56856870033372 0.254921690112557 no 866 0.284824435450547 330 6144269 SGTC_527 4476-4215 268 µM 0.568043176271855 0.255102946629113 no 867 0.285002825352837 297 4418754 SGTC_990 3985-0011 41.3 µM 0.567667816733181 0.25523245172434 no 868 0.285130274299593 327 5399565 YGL099W LSG1 SGTC_1676 st018489 23.4 µM 0.567098773789656 0.255428846254399 no 869 0.285323537976671 303 3696235 SGTC_2389 9091542 195.52 µM 0.566688510444938 0.255570489950758 no 870 0.28546291414419 313 3626624 YOL127W RPL25 SGTC_854 0422-0053 192 µM 0.56519544951571 0.256086316385584 no 871 0.285970415736236 318 3596728 SGTC_747 3448-8087 38.7 µM 0.564416967491169 0.256355483522874 no 872 0.28623519706852 329 5168703 SGTC_3038 9091290 49.47 µM 0.562489943188785 0.257022403125501 no 873 0.286891126850055 332 25236843 SGTC_1400 3771-8998 51.5 µM 0.558216053974701 0.258504758133985 no 874 0.288348429808787 304 670767 SGTC_371 0195-0006 7.36 µM 0.556562151431594 0.259079583447754 no 875 0.288913309647808 304 3928593 SGTC_1158 4092-0494 91.8 µM 0.5540317271114 0.259960327414857 no 876 0.289778566342725 321 1148199 SGTC_844 0330-0132 15.3 µM 0.552813611942741 0.260384856663788 no 877 0.290195523342185 329 2828079 SGTC_35 0133-0054 64.071 µM 0.552383145037119 0.260534965426349 no 878 0.290342938001012 323 99677 SGTC_2091 4-phenylthiadiazole 200 µM 0.55221114231699 0.260594957209651 no 879 0.290401850642262 316 270010 SGTC_2370 9071495 200 µM 0.551479283198674 0.260850297380535 no 880 0.290652582210089 337 21791103 SGTC_2331 7980721 200 µM 0.55107523225554 0.260991322851347 no 881 0.290791051576705 323 2981221 SGTC_3186 9110464 49.47 µM 0.550994838232197 0.261019387367208 no 882 0.290818606507573 329 17018021 SGTC_3125 9127534 49.47 µM 0.550526163591237 0.26118302651757 no 883 0.290979268333227 305 1639235 SGTC_2248 tofa 1.1 µM 0.550483612576614 0.261197885941464 no 884 0.29099385688872 320 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_1825 st052143 62.6 µM 0.550226014976834 0.261287851988347 no 885 0.291082181158953 328 674173 SGTC_3168 9103419 49.47 µM 0.547816638693498 0.262130097564324 no 886 0.291908906296223 326 16649256 SGTC_2916 7875993 68.79 µM 0.546469024458795 0.262601788997926 no 887 0.292371787225668 346 1299250 SGTC_1457 k015-0032 57.3 µM 0.545083279438876 0.263087279521335 no 888 0.292848120993346 327 4302660 SGTC_191 3914-0123 66.505 µM 0.544541230024147 0.263277309198651 no 889 0.293034542156139 339 3144412 SGTC_857 0438-0306 1.35 µM 0.543775923246074 0.26354572692066 no 890 0.293297839490341 305 4686136 SGTC_1293 1000-1278 195 µM 0.543747663371849 0.26355564124114 no 891 0.293307564160279 342 678847 SGTC_2055 5235184 200 µM 0.542945180643671 0.263837253081235 no 892 0.293583773515886 353 2836034 SGTC_3069 9117009 49.47 µM 0.542922383174895 0.263845255540256 no 893 0.293591622015898 300 41904981 SGTC_1069 diphenylcyclopropenone 8.49 µM 0.542617479242961 0.263952296037065 no 894 0.293696600835809 343 65057 A dermal irritant. YDR527W RBA50 SGTC_2514 salinomycin 42.74 µM 0.542118514502183 0.264127511843339 no 895 0.293868432512017 337 23682228 A polyether potassium ionophore. SGTC_2088 5278280 127.392 µM 0.541573148481614 0.26431908961188 no 896 0.294056296864321 321 791502 SGTC_62 0180-0423 3.232 µM 0.540854419096528 0.26457167497922 no 897 0.294303965122431 343 30102 YGL099W LSG1 SGTC_300 r073-0011 5.04 µM 0.538606026876501 0.265362626789029 no 898 0.295079364041815 318 2735780 SGTC_581 0958-0271 211 µM 0.537767802743036 0.265657808703052 no 899 0.295368681453417 304 4591145 SGTC_2620 irigenin 100 µM 0.537585119738397 0.265722162894285 no 900 0.295431752758499 328 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro. SGTC_1912 st060209 90.8 µM 0.537472437757654 0.265761861593408 no 901 0.295470659299817 351 688787 SGTC_2035 5154463 94.595 µM 0.537206361058921 0.265855614321621 no 902 0.295562538921283 351 2769623 SGTC_3320 9137005 35.139 µM 0.535730548529738 0.266375924333707 no 903 0.296072393826167 336 4908713 SGTC_1462 k081-0014 26.5 µM 0.535591073750257 0.266425123965189 no 904 0.296120599609817 305 3270634 SGTC_65 0798-0905 34.986 µM 0.534899781287235 0.266669044742841 no 905 0.296359579784894 363 3602145 SGTC_2031 5180455 200 µM 0.534819820222041 0.26669726608293 no 906 0.296387228072487 329 29949 SGTC_25 0118-0223 35.662 µM 0.534684824018171 0.266744914869204 no 907 0.296433908646392 339 5333628 SGTC_1738 st035555 74 µM 0.534284517301543 0.266886233979851 no 908 0.29657235121538 356 5331140 SGTC_1420 4'-methoxyflavone 42 µM 0.533528908013071 0.267153087560841 no 909 0.296833752754529 324 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13 SGTC_3024 9090631 49.47 µM 0.532465305284795 0.267528941258998 no 910 0.297201882593673 310 25236383 SGTC_2068 5226020 147 µM 0.530958854389442 0.268061743573705 no 911 0.297723646027836 332 1810509 SGTC_2017 5132927 60.65 µM 0.530834520006904 0.268105742072055 no 912 0.297766728248124 323 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis SGTC_835 0312-0010 67.2 µM 0.530413398789118 0.268254792221229 no 913 0.297912669081513 323 1626196 SGTC_178 4092-0806 87.505 µM 0.530348735900257 0.268277682466127 no 914 0.297935081089306 311 2169044 SGTC_1434 4073-0095 163 µM 0.529981526227141 0.268407690949346 no 915 0.29806236968697 328 24133745 SGTC_1246 0422-0085 105 µM 0.52849332695834 0.268934903555416 no 916 0.29857848870663 370 264295 SGTC_2595 hexamethylquercetagetin 100 µM 0.523757472592706 0.270616089629589 no 917 0.300223617984381 361 386331 SGTC_3177 9107506 49.47 µM 0.523640168909438 0.270657797914953 no 918 0.300264418609161 326 8897194 SGTC_1828 st055811 49 µM 0.521629856781192 0.271373079402916 no 919 0.300964035539415 356 5877589 SGTC_3334 9142812 21.919 µM 0.520989920981359 0.271600970000046 no 920 0.301186896328605 343 45283678 SGTC_2436 5633522 8.09 µM 0.519558246636584 0.272111155221365 no 921 0.301685752964751 325 5724242 SGTC_151 3013-0144 2.285 µM 0.518702771737152 0.272416235758385 no 922 0.30198401426668 352 906558 YHR107C CDC12 SGTC_2412 st077135 33.4 µM 0.516246408021371 0.273293170399117 no 923 0.302841160620131 360 13258915 SGTC_597 k018-0003 82.8 µM 0.513280437366277 0.274353897439259 no 924 0.303877583096684 350 6786234 SGTC_201 4262-0159 12.803 µM 0.511648942353719 0.274938238025411 no 925 0.304448362850366 339 1341029 SGTC_937 3122-0005 46.7 µM 0.509399679729225 0.275744844120099 no 926 0.30523605039471 328 759535 SGTC_2480 5767542 37.17 µM 0.50901322594389 0.275883546963941 no 927 0.305371476771107 344 2867358 SGTC_447 ml7 120 µM 0.506840681610752 0.276663936234522 no 928 0.306133304680219 354 4216 Selective myosin light chain kinase inhibitor. SGTC_2681 menadione 3.18 µM 0.506606528386032 0.276748109830631 no 929 0.306215463382193 346 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_969 1313-0238 134 µM 0.504875367195656 0.277370818086395 no 930 0.306823188147826 345 5212874 SGTC_38 0929-0051 58.268 µM 0.504095467505715 0.277651575982627 no 931 0.307097145922783 358 1379719 SGTC_578 3460-0051 92 µM 0.503804453770917 0.277756374245138 no 932 0.307199398821867 372 2876744 SGTC_906 1165-0455 526 µM 0.501220112422238 0.278687879518595 no 933 0.308108110554905 344 3252859 SGTC_2219 9098279 200 µM 0.499461886920134 0.279322486086995 no 934 0.308727015162937 328 902349 SGTC_1405 3909-7894 12 µM 0.498833017785103 0.279549637839661 no 935 0.308948512495645 341 7104060 SGTC_1882 5615643 20 µM 0.498027749246704 0.279840637127455 no 936 0.309232241857542 317 2253075 SGTC_2951 9072950 58.06 µM 0.497970039324743 0.279861497359623 no 937 0.309252579818421 338 16488155 SGTC_2737 bleomycin 30.5 nM 0.497733924967742 0.279946852761616 no 938 0.309335796632375 329 16211318 Bleomycin acts by induction of DNA strand breaks. SGTC_953 1188-0045 9.7 µM 0.49768608869373 0.279964147124838 no 939 0.309352657376102 352 6144426 SGTC_3243 9134147 49.47 µM 0.497270007997832 0.280114595624327 no 940 0.309499329328849 346 24282180 SGTC_2575 plumbagin 510 nM 0.495518407141679 0.280748377359869 no 941 0.310117115990091 327 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_2477 5967686 25.23 µM 0.494735194465979 0.281031991402358 no 942 0.310393527421335 349 776118 SGTC_1885 st057546 99.9 µM 0.494519897214576 0.281109978287312 no 943 0.31046952890779 333 702008 SGTC_3294 9122953 26.2835 µM 0.493020462861059 0.281653406468435 no 944 0.310999064361058 337 16459826 SGTC_1332 1480-0653 17.5 µM 0.492803608453174 0.281732041210756 no 945 0.311075680406461 338 5749438 SGTC_13 0199-0087 65 µM 0.492407967231661 0.281875534062569 no 946 0.311215484068605 342 4589825 SGTC_493 zm226600 134 µM 0.491315678287878 0.282271872805212 no 947 0.311601596316406 356 5240098 A potassium channel opener. YCR052W RSC6 SGTC_996 3970-0799 1.8 µM 0.489689445923932 0.282862450116036 no 948 0.31217683565001 349 6615648 YGL040C HEM2 SGTC_3142 9086498 49.47 µM 0.486093760431355 0.284170350279373 no 949 0.313450345309661 339 25236367 SGTC_2742 clothiapine 36.27 µM 0.485322656043914 0.284451209092596 no 950 0.313723743409119 349 16351 An atypical antipsychotic. YIL048W NEO1 SGTC_1451 4152-0210 104 µM 0.483481218822045 0.285122450443026 no 951 0.314377045984999 370 659563 SGTC_2442 5158906 48.48 µM 0.482575822206898 0.285452762587776 no 952 0.314698474850576 333 1893835 SGTC_265 mycophenolic acid 32.932 µM 0.482205427317289 0.285587944736396 no 953 0.314830010881131 345 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1 SGTC_2384 9036245 200 µM 0.479772676665037 0.286476576362375 no 954 0.315694521765146 322 6462766 SGTC_1855 st056195 39.6 µM 0.47949973314652 0.286576358576145 no 955 0.315791579004585 338 4028379 SGTC_385 1494-0393 12.4 µM 0.478805362929782 0.286830279514514 no 956 0.316038550552893 357 3090647 SGTC_687 k029-0044 34.9 µM 0.477480182893108 0.287315174003744 no 957 0.316510114520243 356 5829338 SGTC_1338 1486-1223 76 µM 0.477325095401079 0.287371947159918 no 958 0.316565321768213 351 3444526 SGTC_2428 5615643 7.78 µM 0.475598453639152 0.288004380164647 no 959 0.31718023863479 375 2253075 SGTC_2739 tacrine 100.86 µM 0.474792699054925 0.288299735996012 no 960 0.317467368681637 332 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders. SGTC_3032 9089427 49.47 µM 0.474282454733361 0.288486843995173 no 961 0.317649250690765 335 17173707 SGTC_126 0417-1624 672.48 µM 0.473466292351248 0.28878625191405 no 962 0.317940271949093 385 41912 YDL195W SEC31 SGTC_1298 1079-1278 263 µM 0.472846056048102 0.289013882436309 no 963 0.318161506534569 351 2840950 SGTC_639 0833-0042 114 µM 0.472622451871467 0.289095967233521 no 964 0.31824128072691 355 5978911 YPR085C | YHR062C ASA1 | RPP1 SGTC_1239 0337-0584 35.4 µM 0.469933231151 0.29008403438422 no 965 0.319201360680587 367 914301 YML130C ERO1 SGTC_1783 st039459 87.517 µM 0.469712248846638 0.290165297507628 no 966 0.319280307731746 407 729761 SGTC_164 4100-3994 89.624 µM 0.468901408963801 0.290463563766443 no 967 0.319570054578194 383 4615967 SGTC_795 0685-0265 78 µM 0.468484561396533 0.290616956363526 no 968 0.319719054460018 350 302754 SGTC_600 1495-0418 41.6 µM 0.468211329037195 0.290717521638698 no 969 0.31981673566168 346 5377768 SGTC_1093 fluphenazine 7.97 µM 0.467060636341083 0.291141221440881 no 970 0.320228248040562 366 6602611 An atypical antipsychotic. SGTC_182 3448-4371 550.524 µM 0.466976662463367 0.29117215298575 no 971 0.320258287565968 315 3491403 SGTC_2238 6671620 73.2395 µM 0.465739019485033 0.291628213204409 no 972 0.32070115949312 313 729941 SGTC_2140 5586273 200 µM 0.464956142917076 0.291916867961887 no 973 0.320981431982076 348 854421 SGTC_991 3996-0057 64.7 µM 0.464441151730414 0.292106823110481 no 974 0.321165856235559 324 715343 SGTC_2195 6536160 144.242 µM 0.464403550980955 0.292120694447522 no 975 0.321179323223987 340 3834386 SGTC_1551 6-bromo-3'-methylflavone 63.5 µM 0.462727463228851 0.292739333124479 no 976 0.321779865189244 351 688751 SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM 0.462522594230524 0.292814991330916 no 977 0.321853301701134 350 4330530 SGTC_702 1488-0190 94 µM 0.461230926719473 0.293292213597016 no 978 0.322316467759893 337 949357 SGTC_2298 7976326 193.81 µM 0.460354755733651 0.293616130676363 no 979 0.32263080225235 338 2235818 SGTC_462 ag-879 158 µM 0.457110217878502 0.294817063729041 no 980 0.323795913175793 370 6809654 Ag-879 is a 5-Lipoxygenase inhibitor. SGTC_967 1306-0166 352 µM 0.456519517572561 0.295035948931257 no 981 0.324008219537911 362 4437607 SGTC_2424 5537928 59.2 µM 0.455868299788184 0.295277345726459 no 982 0.324242343127396 348 5382802 SGTC_2743 auranofin 4.32 µM 0.455860425694339 0.295280265092653 no 983 0.324245174420173 311 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold. SGTC_2082 5219693 150 µM 0.455104514432893 0.295560585427338 no 984 0.32451702519612 340 2834649 SGTC_412 gemfibrozil 100 µM 0.454495461724871 0.295786534053938 no 985 0.32473612881257 352 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels. SGTC_722 3534-0461 190 µM 0.453267613771781 0.29624228670698 no 986 0.325178025217272 329 658262 SGTC_2793 7325131 81.82 µM 0.453141461099643 0.2962891303014 no 987 0.325223440884878 355 4176441 SGTC_2602 kawain 100 µM 0.452528510840839 0.296516782162928 no 988 0.325444143349581 333 5369129 SGTC_3090 9117696 49.47 µM 0.450714290950503 0.297191058965914 no 989 0.326097740546311 371 7923821 SGTC_1522 st012842 45.6 µM 0.450629297173247 0.29722266511285 no 990 0.326128373825666 361 3491067 YOR116C RPO31 SGTC_973 1325-0077 65.9 µM 0.449627501997789 0.297595312632253 no 991 0.32648952711429 373 2835149 SGTC_2954 9074818 52.69 µM 0.448585605624922 0.297983103056176 no 992 0.326865309738645 370 16648742 SGTC_450 aminopyrene 156 nM 0.447877910947765 0.298246635984601 no 993 0.327120655447827 377 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1 SGTC_1061 3448-9325 110 µM 0.44787713605036 0.298246924600791 no 994 0.327120935085563 384 723482 SGTC_3263 9137018 49.47 µM 0.447201419857297 0.298498648419394 no 995 0.327364818159209 353 43844957 SGTC_161 4065-0411 162.148 µM 0.447074807878428 0.298545825792522 no 996 0.327410523828508 369 1906281 YLR208W SEC13 SGTC_1806 st050005 60.3 µM 0.446371668973301 0.298807886763151 no 997 0.327664397068121 345 5194765 SGTC_401 neomycin 50 µM 0.446185464092673 0.298877303116977 no 998 0.327731640998675 340 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis. SGTC_1422 4031-0024 15.5 µM 0.443377631465552 0.299924937624089 no 999 0.328746306263066 383 782427 SGTC_3309 9129340 25.759 µM 0.442998967733211 0.300066348491114 no 1000 0.328883240678127 337 17158987 SGTC_2096 5468907 200 µM 0.441965235493177 0.300452546248164 no 1001 0.329257181401769 347 759785 SGTC_2128 5255449 168.493 µM 0.441896074480395 0.300478392505897 no 1002 0.329282205703438 324 736008 SGTC_2915 7971052 15.16 µM 0.441476676765722 0.300635147710932 no 1003 0.32943397137595 350 5741558 SGTC_2226 7298446 200 µM 0.440766292956725 0.300900746835711 no 1004 0.329691099055133 385 3283010 SGTC_2157 5649910 96.377 µM 0.44024303826583 0.30109644956035 no 1005 0.32988054573337 353 2858091 SGTC_1854 st056233 32.9 µM 0.438582701847493 0.301717812157914 no 1006 0.330481966656943 364 5393174 SGTC_1984 st072354 53.1 µM 0.438520207477096 0.301741211241993 no 1007 0.330504612453597 381 5762938 SGTC_1076 itraconazole 331 nM 0.437817125007696 0.302004514925663 no 1008 0.330759427954066 349 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1 SGTC_1975 st070967 30.8 µM 0.437675290059259 0.302057644478806 no 1009 0.330810842166546 384 261391 SGTC_931 2812-0076 566 µM 0.437171751839528 0.30224629733062 no 1010 0.330993397150082 363 3450959 SGTC_2230 bromochlorosalicylanilide 954.5 nM 0.437094092882046 0.302275397312639 no 1011 0.331021555551751 347 77254 SGTC_198 3454-2873 16.191 µM 0.436760671312089 0.30240034968334 no 1012 0.331142461911496 364 710957 SGTC_682 0kpi-0099 17 µM 0.436572904289416 0.302470727054728 no 1013 0.331210558320262 375 1714895 YML126C ERG13 SGTC_63 0099-0242 26.702 µM 0.436439535478788 0.30252071977255 no 1014 0.33125892982663 341 3898502 YLR359W ADE13 SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM 0.435036056560043 0.303047032152233 no 1015 0.331768127889323 359 279621 SGTC_464 bw-b 70c 158 µM 0.434397502803513 0.303286628872958 no 1016 0.331999905416632 384 5353454 SGTC_2717 st081029 62.2815 µM 0.433774280182676 0.303520554695612 no 1017 0.332226180165721 383 5292846 SGTC_933 2914-0560 114 µM 0.433118138427625 0.303766923713629 no 1018 0.332464473044365 334 463887 SGTC_725 1497-0963 19 µM 0.433095573467995 0.303775398022944 no 1019 0.332472669230468 375 3549977 SGTC_858 0438-0351 2.77 µM 0.432190571087596 0.304115360131967 no 1020 0.332801455860368 343 2799119 SGTC_1402 3909-7673 35.9 µM 0.429837343644077 0.305000137222842 no 1021 0.333656982992984 362 5328014 SGTC_968 1309-0633 340 µM 0.429081047247738 0.305284735529054 no 1022 0.333932122207747 369 3761976 SGTC_2854 9024559 71.43 µM 0.428818198314505 0.305383674545495 no 1023 0.334027767076063 364 3163529 SGTC_2466 5983409 37.09 µM 0.428755511622736 0.305407272554936 no 1024 0.33405057895841 370 2879657 SGTC_589 1227-0070 34.1 µM 0.427882856801974 0.305735861897174 no 1025 0.334368204409692 359 2841384 SGTC_2896 9052656 71.43 µM 0.427671321822725 0.305815536825239 no 1026 0.334445215944823 365 6469436 SGTC_955 1216-0110 33 µM 0.426051997140494 0.306425761885207 no 1027 0.335034978742232 372 3619719 SGTC_2375 9072683 200 µM 0.425061116802653 0.306799429528316 no 1028 0.335396061081827 384 16798029 SGTC_2346 9031566 143.75 µM 0.424785493278833 0.30690340473427 no 1029 0.335496526889459 380 4771086 SGTC_2898 9056270 58.44 µM 0.42322176516658 0.307493593664807 no 1030 0.336066734149676 362 19154699 SGTC_2335 9018011 154.17 µM 0.422837239484768 0.307638799441358 no 1031 0.33620700778616 394 6458208 SGTC_2379 9035213 200 µM 0.421723145088473 0.308059677324134 no 1032 0.336613554279477 384 646551 SGTC_2215 7188065 200 µM 0.420352965965327 0.308577644101788 no 1033 0.337113811114925 385 940217 SGTC_3164 9100705 49.47 µM 0.419467821734702 0.308912456580423 no 1034 0.337437133420138 379 17174235 SGTC_2698 st077697 67.5 µM 0.419441414227622 0.308922447860539 no 1035 0.337446781305013 352 3154499 SGTC_1234 0326-0494 15.5 µM 0.418813746387838 0.309159967587703 no 1036 0.337676128868626 390 1547813 SGTC_730 1436-0052 41.2 µM 0.418343475649568 0.309337977982805 no 1037 0.337848003616262 346 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2 SGTC_1456 k015-0012 13 µM 0.418249317623857 0.309373624761568 no 1038 0.337882420595466 379 2989616 SGTC_1421 4029-0249 71.4 µM 0.418113237273257 0.309425145856961 no 1039 0.337932163568111 375 2894095 SGTC_510 ag-490 170 µM 0.41683602426136 0.309908891269548 no 1040 0.338399175368395 353 5328779 SGTC_1176 0848-0131 83.3 µM 0.416229846957849 0.310138596678149 no 1041 0.338620910625405 386 6769040 SGTC_1174 0739-0097 51.1 µM 0.415000077908558 0.310604834150236 no 1042 0.339070923045277 376 728447 SGTC_2619 obliquin 87.91 µM 0.414486386063425 0.310799678276637 no 1043 0.339258967622204 380 6708593 A bioactive alkalod. YER133W GLC7 SGTC_3130 9127414 49.47 µM 0.414286135859544 0.310875647873352 no 1044 0.339332283051569 351 1494646 SGTC_1035 k081-0041 55.2 µM 0.41385498505969 0.311039242371665 no 1045 0.339490156248291 397 731709 SGTC_2890 9046729 58.44 µM 0.408667942538004 0.31301031709969 no 1046 0.341391681318282 360 903329 SGTC_3225 9130819 49.47 µM 0.407954047663042 0.313282017535571 no 1047 0.341653705876308 372 4547121 SGTC_254 nsc-64875 3.808 µM 0.406957494984925 0.313661463905267 no 1048 0.342019603409734 369 56993 SGTC_3278 9139605 49.47 µM 0.403393509939055 0.315020094855798 no 1049 0.343329380213968 376 7958859 SGTC_2489 cantharidin 73.42 µM 0.402762891712091 0.315260755095966 no 1050 0.343561331200821 375 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_2659 sanguinarine 24.21 µM 0.402575006516494 0.315332472116574 no 1051 0.343630449632807 380 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis. SGTC_1185 1319-0113 81.3 µM 0.402022126405646 0.315543550466483 no 1052 0.343833871211537 385 4672763 SGTC_2255 7941087 197.44 µM 0.401357548332065 0.315797352486406 no 1053 0.344078449743658 380 935561 SGTC_1238 0333-0287 48.8 µM 0.400514170571218 0.316119563088443 no 1054 0.344388924200297 364 7226 SGTC_2918 7977171 22.06 µM 0.400465642911345 0.316138107226041 no 1055 0.344406791984499 364 2236483 SGTC_121 0557-0495 61.343 µM 0.400209200046209 0.316236110807004 no 1056 0.344501219483222 410 3104427 SGTC_1509 1326-1131 80 µM 0.400067493420963 0.316290271709741 no 1057 0.344553402913605 363 768313 SGTC_1243 0416-0003 5.65 µM 0.398924565668875 0.316727247788785 no 1058 0.344974393862764 378 2141977 SGTC_547 1120-0019 610 nM 0.397038427756623 0.317448935070104 no 1059 0.345669561687536 365 3676939 SGTC_179 1273-0063 6.77 µM 0.396215156760541 0.317764158663216 no 1060 0.345973155438339 399 3108139 SGTC_2858 9025781 8.96 µM 0.395725967474447 0.317951527756337 no 1061 0.34615359838053 374 4894980 YPL153C RAD53 SGTC_2712 st079126 47.7 µM 0.393818476612827 0.318682579065691 no 1062 0.346857531082329 381 3152970 SGTC_2745 rifampicin 24.3 µM 0.391346644520216 0.319630966170727 no 1063 0.347770512576002 383 25141428 Inhibits bacterial DNA-dependent RNA polymerase. SGTC_2191 5911152 200 µM 0.389973175310031 0.320158446559608 no 1064 0.348278191346394 375 2875902 SGTC_2651 TUB2.036 5 µM 0.389523003751055 0.320331413982958 no 1065 0.348444648580676 376 15992207 YFL037W TUB2 SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM 0.388861904332364 0.320585496041692 no 1066 0.348689152246814 373 521171 SGTC_583 1488-1091 88.9 µM 0.388712004678689 0.320643119065341 no 1067 0.348744600483474 401 4303273 SGTC_36 0335-0881 14.2 µM 0.388404186330635 0.320761461268052 no 1068 0.348858473347314 367 23828853 SGTC_1494 4358-1428 177 µM 0.388180019286061 0.32084765480087 no 1069 0.348941409212053 381 1564571 SGTC_2641 levomentholum 100 µM 0.388176205170514 0.320849121434057 no 1070 0.348942820396162 385 16666 SGTC_3345 9148410 3.559 µM 0.387807898677075 0.320990758660382 no 1071 0.34907909990653 383 4903596 SGTC_1476 4112-3294 3.34 µM 0.387670706485482 0.321043524427406 no 1072 0.349129868269472 395 704369 SGTC_2147 5545932 89.7195 µM 0.387393633163806 0.321150101178254 no 1073 0.349232408277341 397 797404 SGTC_522 1273-0010 11.6 µM 0.386783693021196 0.321384767654282 no 1074 0.349458175270241 402 5705015 SGTC_1634 st006576 41 µM 0.386164230025516 0.321623170919768 no 1075 0.349687521632185 409 3915356 SGTC_1661 st013063 9.66 µM 0.384746826400957 0.322168941693609 no 1076 0.350212499159714 388 721395 SGTC_2570 licareol 100 µM 0.382351105402016 0.323092285077252 no 1077 0.351100476181374 370 443158 SGTC_3116 9124943 49.47 µM 0.381283504097389 0.323504104931239 no 1078 0.351496446334957 343 41905195 YPL160W CDC60 SGTC_1284 0929-0043 16 µM 0.380498420544849 0.323807083546809 no 1079 0.35178773438222 386 1239883 SGTC_1104 tacrolimus 29.8 µM 0.38019575912594 0.323923917524652 no 1080 0.351900053519634 385 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41 SGTC_468 gf-109203x 121 µM 0.379527095249562 0.324182098007525 no 1081 0.352148243773776 380 2396 A protein kinase C inhibitor. SGTC_2338 7999974 200 µM 0.379112682971515 0.324342150846476 no 1082 0.352302094218213 395 315925 SGTC_873 0591-4978 488 µM 0.378730176541473 0.324489909930364 no 1083 0.352444121079017 417 3305145 SGTC_3183 9108214 49.47 µM 0.378589124373311 0.324544404196515 no 1084 0.352496499762749 382 4974831 SGTC_2179 6298986 200 µM 0.378386906888845 0.324622535698765 no 1085 0.352571596615492 383 738374 SGTC_3162 9099653 49.47 µM 0.378028434414396 0.324761058974896 no 1086 0.352704735498755 362 25237511 SGTC_2185 6113692 200 µM 0.377022690708636 0.32514983438092 no 1087 0.35307837117988 382 874150 SGTC_2079 5212404 121 µM 0.376468291957121 0.325364221516625 no 1088 0.353284391966393 370 758462 SGTC_219 mitoxanthrone 164.414 µM 0.375396134832074 0.325778990819159 no 1089 0.353682939516523 381 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA.  YMR168C CEP3 SGTC_2654 protoveratrine a 100 µM 0.374568086809925 0.326099472991629 no 1090 0.353990855449548 406 5702278 A heart drug and vasodilator. SGTC_1479 0549-0158 134 µM 0.372656249810743 0.326839908089003 no 1091 0.354702151086708 346 5440202 SGTC_2973 9094665 17.96 µM 0.37226931088932 0.326989848734669 no 1092 0.354846172797102 415 25237061 YIL048W NEO1 SGTC_1149 3909-7961 23.3 µM 0.372149348484115 0.327036340402805 no 1093 0.354890827962073 376 735261 SGTC_2407 paclitaxel 400 µM 0.371870429909896 0.327144446225167 no 1094 0.354994661152756 434 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_154 3389-1638 511.116 µM 0.37178594900221 0.327177192973373 no 1095 0.355026113038128 412 5238686 SGTC_2103 5378138 10 µM 0.371712019085768 0.327205851005577 no 1096 0.355053637644517 385 244142 SGTC_1861 st057647 17.4 µM 0.37038807970188 0.327719232321133 no 1097 0.355546677141849 429 688668 SGTC_2121 5257820 149.641 µM 0.369694432593174 0.327988336607439 no 1098 0.355805090257079 376 791256 SGTC_1074 carmofur 3.8 µM 0.369598999148892 0.328025367540561 no 1099 0.355840648471818 373 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_2418 pentamidine 31.67 µM 0.368567981458971 0.328425539912656 no 1100 0.35622488247836 382 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_929 2805-0021 398 µM 0.367324070750003 0.328908605249685 no 1101 0.356688650635193 397 3098024 SGTC_2616 abietic acid 100 µM 0.366992065015939 0.329037586080004 no 1102 0.356812468441292 398 6708678 Abietic acid is an inhibitor of 5α-reductase. SGTC_333 3486-0131 40.1 µM 0.366981594169214 0.329041654228024 no 1103 0.356816373671343 398 6744690 SGTC_2398 5228213 48.84 µM 0.364535462029658 0.329992582923813 no 1104 0.357729098951998 404 80771 YMR134W ERG29 SGTC_2740 felodipine 17.08 µM 0.362149906086856 0.330921022049424 no 1105 0.35862000571938 415 3333 L-type calcium channel blocker SGTC_587 k089-0003 57 µM 0.361172821318777 0.331301596360244 no 1106 0.358985129117374 397 9659696 SGTC_2980 9014342 25.29 µM 0.360749995573176 0.331466340954589 no 1107 0.359143173364095 406 2996599 SGTC_998 3996-0085 177 µM 0.359650803816913 0.331894768965239 no 1108 0.359554143142813 385 715391 SGTC_1374 2889-5571 141 µM 0.359560765085771 0.331929872788936 no 1109 0.359587814354854 368 2853281 SGTC_1370 2001-0092 44.6 µM 0.358862589331965 0.332202123910319 no 1110 0.35984894368488 412 790957 SGTC_230 MPP+ 141.667 µM 0.358021661943718 0.332530158114721 no 1111 0.360163551357515 391 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death. SGTC_383 2324-0395 7.37 µM 0.357598854454738 0.332695137982963 no 1112 0.360321767855659 394 3146421 SGTC_3139 9095020 49.47 µM 0.357059354806987 0.332905698290024 no 1113 0.360523685829228 385 25236292 SGTC_1118 chelidonine 707.474 nM 0.355858270253227 0.333374656525132 no 1114 0.36097335412669 399 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor. SGTC_1870 st057514 26.5 µM 0.355640978285278 0.333459525082832 no 1115 0.361054725578051 373 5393161 SGTC_1311 1190-0148 100 µM 0.355404182208536 0.333552021142313 no 1116 0.361143408084408 401 1961333 SGTC_1177 0983-0204 23.6 µM 0.354594735872181 0.33386827927431 no 1117 0.361446610194624 389 766818 SGTC_2175 5807670 165.306 µM 0.35296519735779 0.334505312806875 no 1118 0.362057265939466 372 241186 SGTC_1609 st001574 46.4 µM 0.352273619754014 0.334775814628199 no 1119 0.362316535059514 441 3960012 SGTC_3261 9137475 49.47 µM 0.35133183916616 0.335144318073034 no 1120 0.362669705643171 391 17027690 SGTC_1084 voriconazole 435 nM 0.349901172326422 0.335704418391055 no 1121 0.363206433596211 410 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_114 0364-0001 490.298 µM 0.349426994601166 0.335890137704655 no 1122 0.363384385119505 368 4003655 SGTC_1448 4255-0083 152 µM 0.346182147196536 0.337162107796722 no 1123 0.364602915340612 413 5399660 SGTC_914 3820-6779 408 µM 0.34547962953286 0.33743773847267 no 1124 0.364866910955288 359 2893481 SGTC_1517 deoxycholic acid methyl ester 49.2 µM 0.344492649102194 0.337825124627307 no 1125 0.365237911646247 391 229346 A bile salt which induces apoptosis. SGTC_2638 epoxomicin 18 µM 0.34403886853684 0.33800328950936 no 1126 0.365408527702646 413 9915668 A protesome inhibitor. SGTC_2676 harmalol 100 µM 0.343588310353627 0.33818022511755 no 1127 0.365577958537304 387 5459187 A monoamine oxidase inhibitor SGTC_3277 9138724 49.47 µM 0.343192134506602 0.338335834148403 no 1128 0.365726960757939 408 15943418 SGTC_1157 4092-0394 27.6 µM 0.343179311735594 0.338340871108163 no 1129 0.3657317837564 367 3659885 SGTC_964 1287-0107 19.4 µM 0.34283083623689 0.338477768121149 no 1130 0.365862863143056 403 51516812 YPR165W RHO1 SGTC_136 0097-0015 404.482 µM 0.342820138270355 0.338481971106433 no 1131 0.365866887441071 364 4861337 SGTC_3297 9117502 71.43 µM 0.341970232634013 0.338815943761084 no 1132 0.366186647064255 370 7453720 SGTC_1793 st048256 72.231 µM 0.341893753756201 0.338846002557043 no 1133 0.366215425240145 415 672022 SGTC_1145 3546-0597 10.2 µM 0.341182457806754 0.339125615153483 no 1134 0.366483114250199 384 875334 SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM 0.341176445179842 0.339127979113345 no 1135 0.366485377318394 406 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_694 1315-0438 43.2 µM 0.341034057131945 0.339183963088808 no 1136 0.366538971533333 403 6793154 SGTC_610 4215-0184 155 µM 0.340879853691688 0.339244596632026 no 1137 0.366597015943752 408 5605015 SGTC_1503 4585-0012 61.3 µM 0.34027599799442 0.339482075689064 no 1138 0.366824345339704 389 2922052 SGTC_704 1310-0270 142 µM 0.339347518288994 0.339847344372772 no 1139 0.367173974811853 408 5718033 SGTC_2376 9072922 81.32 µM 0.338361190110656 0.340235535716533 no 1140 0.367545508459155 399 17087968 SGTC_699 0375-0592 111 µM 0.338094778037871 0.340340417172093 no 1141 0.367645882803026 381 762578 SGTC_693 4161-2696 114 µM 0.337670735011999 0.340507380461712 no 1142 0.367805665381692 397 805759 SGTC_1715 st032160 10.2275 µM 0.337352339241768 0.340632766605789 no 1143 0.367925654326704 417 5289825 SGTC_2430 5571206 200 µM 0.335323038114436 0.341432330797737 no 1144 0.368690708414798 402 1731771 SGTC_808 0711-0032 135 µM 0.33510847730238 0.34151691151921 no 1145 0.368771629131344 415 4252555 SGTC_2237 6667747 47.222 µM 0.335042287051026 0.341543005584953 no 1146 0.368796593683436 430 729940 YDL015C TSC13 SGTC_2122 5258151 111.688 µM 0.334721301894646 0.34166955773554 no 1147 0.368917665444338 381 2173356 SGTC_408 cantharidin 100 µM 0.332874449941555 0.342398046139921 no 1148 0.369614528316398 384 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_20 0481-0013 4.944 µM 0.331582676593389 0.342907933412411 no 1149 0.370102201140043 397 182045 SGTC_3338 9144300 39.5675 µM 0.330669217357681 0.343268665818065 no 1150 0.370447178223474 376 4901274 SGTC_14 0354-0009 295 µM 0.329913184120733 0.343567337491049 no 1151 0.370732780627065 426 1713507 SGTC_2544 sphondin 68.51 µM 0.32873740146239 0.344032025637885 no 1152 0.37117709090309 380 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31 SGTC_2730 imipramine 71.33 µM 0.32868761005673 0.344051709204932 no 1153 0.371195910108317 367 3696 A tricyclic antidepressant. SGTC_2692 st077426 47.7 µM 0.327823035023213 0.344393560836227 no 1154 0.371522734747714 436 25238571 SGTC_255 tunicamycin 200.472 nM 0.326707063425001 0.344835002247889 no 1155 0.371944728668084 395 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_632 0781-2353 4.65 µM 0.326672117568848 0.34484882908672 no 1156 0.371957945594589 409 6811515 YHR007C ERG11 SGTC_2081 5214970 32.255 µM 0.325582573991039 0.345280026791522 no 1157 0.372370099176425 398 2063512 SGTC_1883 5-benzylidenerhodanine 20 µM 0.32500509334903 0.345508652000847 no 1158 0.372588608424027 402 1273210 SGTC_2269 7935389 174.42 µM 0.324247506678019 0.345808666855107 no 1159 0.372875329039415 416 97605 SGTC_2142 5622915 118.518 µM 0.323327858358491 0.346172990502698 no 1160 0.373223479080415 387 5322196 SGTC_1696 st025591 34.7925 µM 0.321336680466307 0.346962293977348 no 1161 0.373977631066717 390 2787147 SGTC_1130 3454-2858 15.9 µM 0.320980166960336 0.347103686268493 no 1162 0.374112710394563 450 715628 YIL048W NEO1 SGTC_1802 st050112 57.9 µM 0.320756166582194 0.347192535102619 no 1163 0.374197589759695 392 4662563 SGTC_2819 7996655 46.38 µM 0.320708340205782 0.347211506327563 no 1164 0.374215713164255 443 6456960 SGTC_139 0099-0334 718.624 µM 0.319975221487246 0.347502359441509 no 1165 0.37449355712664 395 97690 SGTC_1353 1498-1206 8.11 µM 0.319935322246524 0.347518191404713 no 1166 0.374508680373285 416 6756808 SGTC_1312 1218-2183 165 µM 0.319026291351397 0.3478789656136 no 1167 0.374853288023651 406 6744073 SGTC_3312 9133330 71.43 µM 0.31832299401084 0.348158183281958 no 1168 0.375119972026152 420 17617324 SGTC_67 0335-0847 266 µM 0.318077910234876 0.348255503898204 no 1169 0.375212919617042 420 4552207 YOR254C SEC63 SGTC_1221 2958-7315 257 µM 0.317239432345032 0.348588531646845 no 1170 0.375530965652199 392 4562705 SGTC_1492 4158-0558 28.5 µM 0.316304731259392 0.348959915033153 no 1171 0.375885610174376 407 3967268 SGTC_608 k048-0125 159 µM 0.316265918635503 0.348975339527149 no 1172 0.375900338739517 416 6817652 YLR060W | YFL022C FRS1 | FRS2 SGTC_802 4112-3352 742 µM 0.315443523109469 0.349302225706565 no 1173 0.376212462817198 371 704594 SGTC_1921 5740136 50 µM 0.314894867342147 0.349520367870809 no 1174 0.376420739389691 431 1774243 SGTC_1592 4',5'-dihydroxyflavone 8.85 µM 0.313176133846926 0.350204047201935 no 1175 0.377073424743906 439 688669 SGTC_3337 9144342 33.5465 µM 0.312038794438822 0.350656726295934 no 1176 0.377505520260061 382 17682949 SGTC_160 3453-0671 289.699 µM 0.310119156823012 0.35142125337987 no 1177 0.378235172450401 394 5322268 SGTC_2667 digitoxin 100 µM 0.309370322774889 0.351719652051868 no 1178 0.378519921407024 403 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_295 k015-0027 31 µM 0.30832019775251 0.352138264358732 no 1179 0.37891934929085 402 3887424 SGTC_889 0919-1524 82.7 µM 0.308051132786076 0.35224555084034 no 1180 0.379021712270796 391 3905452 SGTC_2892 9047358 58.44 µM 0.306292696108663 0.352946995941866 no 1181 0.379690899911002 417 6466771 SGTC_1692 fluoroquinolonic acid 71 µM 0.305969370267512 0.353076025984173 no 1182 0.379813983531886 419 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2 SGTC_624 k048-0052 28 µM 0.304479162662531 0.353670943153661 no 1183 0.380381432702363 396 6835531 SGTC_1519 esterone 74 µM 0.302922614465849 0.354292726470547 no 1184 0.380974418361118 393 698 A steroid. SGTC_3163 9099914 49.47 µM 0.302805695221289 0.354339447087358 no 1185 0.381018971454923 447 16268368 SGTC_1051 3253-3903 78 µM 0.302374856556981 0.354511627980973 no 1186 0.381183159881939 431 5509239 SGTC_542 3381-0244 89.3 µM 0.301210064305909 0.354977275765765 no 1187 0.381627157898699 453 1112843 SGTC_3166 9102297 49.47 µM 0.300068210507004 0.355433963829075 no 1188 0.382062563420979 410 25237072 SGTC_2004 4023728 41.89 µM 0.298713271102602 0.355976145530189 no 1189 0.382579415128974 450 360084 YDR527W RBA50 SGTC_2040 5100729 123 µM 0.298015585287527 0.356255439624624 no 1190 0.382845634231136 405 11840 YJR013W | YDR381W GPI14 | YRA1 SGTC_42 0133-0086 60.653 µM 0.297406731250198 0.356499236057767 no 1191 0.38307800263243 456 162923 Model of phenazepam hydroxylation. SGTC_2966 9084041 48.03 µM 0.297162123729201 0.356597197959527 no 1192 0.383171368648001 384 17741380 SGTC_742 0kpi-0133 140 µM 0.295553929788322 0.357241492510892 no 1193 0.383785380592139 435 2728852 SGTC_3127 9126946 49.47 µM 0.29515492028129 0.3574014117609 no 1194 0.383937768544336 427 27243249 SGTC_3064 1327-0027 10 µM 0.294770826008016 0.35755537678526 no 1195 0.384084477090379 436 16000455 YPR107C YTH1 SGTC_1347 1493-0251 600 nM 0.294665038986294 0.357597785816141 no 1196 0.384124886391344 411 3986378 SGTC_211 3455-0679 143.504 µM 0.294613057818613 0.357618625226001 no 1197 0.384144742999876 398 748649 SGTC_222 nsc-310342 10.666 µM 0.293702351602184 0.357983798962621 no 1198 0.384492678604389 443 432556 SGTC_948 3448-0295 75.3 µM 0.290415858792239 0.359302691166951 no 1199 0.385749056349921 397 678569 SGTC_2320 7373003 200 µM 0.290415359624104 0.359302891614421 no 1200 0.385749247265977 392 5415828 SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM 0.289117518718074 0.35982418733284 no 1201 0.386245723904014 394 6312947 SGTC_344 k064-0035 6.43 µM 0.288600375980668 0.3600319775916 no 1202 0.386443603874079 435 5088750 SGTC_788 1182-0090 188 µM 0.286968875485126 0.360687792619113 no 1203 0.387068076059387 382 5715185 SGTC_1372 2752-0194 270 µM 0.286579437889353 0.36084439570861 no 1204 0.387217180259143 418 823334 SGTC_1213 1315-0166 115 µM 0.286577149842256 0.360845315861441 no 1205 0.387218056334267 387 768401 SGTC_1979 st071809 45.3 µM 0.284266095573226 0.361775131627249 no 1206 0.388103233315623 445 4976333 SGTC_2584 androsterone 48.74 µM 0.281290062510064 0.362973693360103 no 1207 0.389243965853494 406 2754130 A steroid. SGTC_1271 0832-2808 169 µM 0.280930455099782 0.363118612148401 no 1208 0.389381870555637 442 3663794 SGTC_2495 cafestol 54.53 µM 0.279761776778689 0.363589715023048 no 1209 0.389830139417806 425 16667697 An anti-infammatory. SGTC_3154 9100113 49.47 µM 0.279671393875811 0.363626157644708 no 1210 0.389864813618151 404 25237525 SGTC_71 0417-1750 47.813 µM 0.274929070278864 0.365539998498023 no 1211 0.391685366285458 444 6811472 SGTC_2515 chrysin 20.77 µM 0.274888731894381 0.365556292146246 no 1212 0.391700862216856 394 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor. SGTC_1976 st070609 63.5 µM 0.273533175161972 0.36610397515129 no 1213 0.392221697113256 451 682556 SGTC_2891 9063876 19.48 µM 0.272727509051437 0.366429616276049 no 1214 0.392531343435953 431 6472478 SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM 0.272637792860989 0.366465884501458 no 1215 0.392565828793007 397 2333 A French combination drug. SGTC_55 0767-0285 6.563 µM 0.272626910057457 0.36647028401114 no 1216 0.392570012012455 440 3116166 SGTC_1327 1436-0082 2.18 µM 0.271231750039457 0.367034440061682 no 1217 0.393106397452575 428 15992205 SGTC_21 0849-0113 22.993 µM 0.269206001287674 0.36785409617855 no 1218 0.393885581168049 414 1560156 SGTC_923 1900-2434 73.3 µM 0.268916323872874 0.367971354413026 no 1219 0.393997037452914 465 5910570 SGTC_1407 3909-7909 12.3 µM 0.267659324834367 0.368480316216362 no 1220 0.394480780886868 427 4411780 SGTC_3283 9109332 35.8195 µM 0.267383305462638 0.368592108035863 no 1221 0.394587025986699 416 17027281 SGTC_2401 5128683 200 µM 0.265956915689982 0.369169993493579 no 1222 0.395136195307432 429 708373 SGTC_2678 equilin 100 µM 0.26414182552747 0.369905784035447 no 1223 0.395835317946753 411 3247 Equilin is an estrone commonly used hormone replacement therapy SGTC_1053 3366-3204 134 µM 0.263638179384294 0.370110033704208 no 1224 0.396029368054851 410 3632071 YPR165W RHO1 SGTC_2635 hydroquinidine 100 µM 0.262847584351388 0.370430727076854 no 1225 0.396334028817286 406 442912 An experimental heart treatment. SGTC_1808 st050063 61.5 µM 0.262586064105327 0.370536828795341 no 1226 0.396434821232063 456 4011993 SGTC_758 0868-0029 16 µM 0.262148815687404 0.370714247413011 no 1227 0.396603356430077 410 762687 SGTC_986 1493-0483 84 µM 0.259839333122953 0.371651802075662 no 1228 0.397493854634724 445 40079 SGTC_3333 9141820 12.094 µM 0.258975218148442 0.372002793262986 no 1229 0.397827180705616 452 1939433 SGTC_1033 k072-0102 21.3 µM 0.258884808128911 0.372039522677362 no 1230 0.397862060028544 443 5965931 SGTC_1758 st042942 75.2445 µM 0.256965121448606 0.372819677043449 no 1231 0.398602849109797 432 669317 SGTC_540 1187-0821 17.3 µM 0.25472392984884 0.373731150192746 no 1232 0.399468166208751 468 847520 SGTC_2167 5876490 200 µM 0.254620654787574 0.373773168333118 no 1233 0.399508052329188 443 686534 SGTC_2356 9061756 188.97 µM 0.253000831421784 0.374432400165603 no 1234 0.400133785356802 423 20104043 SGTC_1962 st076595 64.5 µM 0.252867984964946 0.374486482018727 no 1235 0.400185114955586 418 279619 SGTC_623 k072-0108 16.9 µM 0.252502873049256 0.37463513196279 no 1236 0.400326196834519 443 5382803 SGTC_1017 4239-0030 168 µM 0.25216773163893 0.37477159625788 no 1237 0.400455709343787 400 1149593 SGTC_1001 4048-4355 44.4 µM 0.2490349637222 0.376047966261275 no 1238 0.401666868035712 437 21824233 SGTC_3105 9121040 49.47 µM 0.246528293390044 0.377070226218264 no 1239 0.402636652595878 444 41448907 SGTC_138 0850-0259 40.9225 µM 0.246139620735355 0.377228810487429 no 1240 0.402787076710671 438 6813004 SGTC_313 3474-0040 5.03 µM 0.245662246419166 0.377423614697099 no 1241 0.402971849838492 446 1043375 YIL048W NEO1 SGTC_631 k072-0230 41.5 µM 0.244299767045989 0.377979778967314 no 1242 0.403499331940393 415 5773147 SGTC_745 0469-0705 296 µM 0.24280318138211 0.378590976993155 no 1243 0.404078935462482 443 3486736 SGTC_1264 0783-0040 158 µM 0.242233880677454 0.378823556376452 no 1244 0.40429947182901 441 2855798 SGTC_1832 st054113 55 µM 0.242129825485526 0.378866071332492 no 1245 0.404339784139414 448 1251267 SGTC_2689 tacrolimus 100 µM 0.242016616433036 0.378912328045199 no 1246 0.404383643925935 459 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). SGTC_2223 6903751 107.57 µM 0.241255019644734 0.379223558136065 no 1247 0.404678735218913 442 5598863 SGTC_643 k048-0106 28.4 µM 0.240097725126584 0.379696641787698 no 1248 0.4051272488637 453 6763920 SGTC_411 enrofloxacin 100 µM 0.239427679896596 0.379970628039612 no 1249 0.405386984307712 456 71188 A bacterial gyrase inhibitor. SGTC_1318 1280-3875 124 µM 0.239238604115186 0.38004795337556 no 1250 0.405460284936233 432 373245 SGTC_1040 k898-0338 155 µM 0.238786032819952 0.380233058567468 no 1251 0.405635750590894 447 20969351 SGTC_1471 k673-0312 37 µM 0.238256878848474 0.380449521458882 no 1252 0.405840932031589 433 24099884 SGTC_3205 9113483 49.47 µM 0.238145244056622 0.380495193083738 no 1253 0.405884222147966 475 17018033 SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM 0.237600563706473 0.380718054631787 no 1254 0.406095456629859 413 5379071 SGTC_2177 5811945 192 µM 0.236468549930709 0.381181356222025 no 1255 0.406534554423985 455 5343475 SGTC_3151 9099821 49.47 µM 0.235825721082243 0.381444523979129 no 1256 0.40678395422315 419 17174189 SGTC_2450 5739737 12.93 µM 0.235820233588974 0.381446770740628 no 1257 0.406786083381541 452 2262825 SGTC_1406 3909-7906 11.9 µM 0.234026547418081 0.382181378927801 no 1258 0.407482184500151 451 X1406 SGTC_2700 st077718 96.8 µM 0.232858418030919 0.382660017259027 no 1259 0.407935674242571 423 904970 SGTC_2289 7946404 165.07 µM 0.230981789395435 0.38342933662789 no 1260 0.408664474739413 428 1246120 YPR165W RHO1 SGTC_73 0327-0325 16.231 µM 0.229290703599611 0.384122987174362 no 1261 0.409321489242085 439 53298 SGTC_1359 1582-0056 520 nM 0.228575361388046 0.384416518544783 no 1262 0.409599488189018 443 3661189 SGTC_908 3448-7491 47.7 µM 0.222916564878475 0.386740855584599 no 1263 0.411800221921213 430 1203031 SGTC_2919 7978188 46.38 µM 0.222091388412273 0.387080136702997 no 1264 0.412121370761286 427 2980291 SGTC_690 glyoxal 20.3 µM 0.221507344643608 0.387320325413062 no 1265 0.412348709216718 441 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins. SGTC_444 curcumin 90.4 µM 0.221432383216059 0.387351156517156 no 1266 0.412377890009114 438 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. SGTC_1646 st011709 75.6 µM 0.220734079505537 0.387638398000726 no 1267 0.412649747139771 459 5757843 SGTC_1525 8-methoxypsoralen 92.5 µM 0.218244922542995 0.388662791608161 no 1268 0.413619142719317 479 4114 Related to psoralen; DNA damaging agent. SGTC_1731 st035964 63 µM 0.217156177217147 0.389111100432465 no 1269 0.41404331762775 445 6739575 SGTC_1046 2001-0062 216 µM 0.217085401423531 0.389140248649451 no 1270 0.414070895336493 446 739778 SGTC_2851 9015922 71.43 µM 0.21690132818982 0.389216060067692 no 1271 0.414142621249639 478 2996893 SGTC_463 ikarugamyin 104 µM 0.216524724037208 0.389371179379199 no 1272 0.414289377615404 474 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis. SGTC_2126 5251174 33.877 µM 0.214327869650846 0.39027639134879 no 1273 0.41514569306329 417 790722 SGTC_2928 9011484 9.79 µM 0.214133095249302 0.390356676770247 no 1274 0.415221634015154 451 2994751 SGTC_764 1951-2361 146 µM 0.213888237654942 0.390457612966551 no 1275 0.415317106489173 450 5438930 SGTC_1222 0366-0074 1.18 µM 0.213751763975979 0.390513873907993 no 1276 0.415370321139345 463 286520 SGTC_666 0272-0154 136 µM 0.213428803486286 0.390647022712362 no 1277 0.415496258047272 446 6870312 SGTC_1328 1441-0025 69.2 µM 0.210755040470337 0.391749841760007 no 1278 0.416539211493035 433 4562601 SGTC_1436 4092-1007 8.32 µM 0.210508447956193 0.391851595167692 no 1279 0.41663542943359 432 2881121 SGTC_594 1487-1584 10.8 µM 0.210339414483405 0.391921349052509 no 1280 0.416701387495165 441 5013332 SGTC_3232 9132874 49.47 µM 0.210204239271083 0.391977133381062 no 1281 0.416754135510701 456 3784940 SGTC_3171 9103192 49.47 µM 0.210132068348816 0.392006917905125 no 1282 0.416782298631986 467 13018434 SGTC_183 3914-0051 30.55 µM 0.209930745706127 0.392090005944877 no 1283 0.416860862639732 458 1596232 SGTC_110 0850-0284 111.64 µM 0.208410119343834 0.392717743645963 no 1284 0.417454377854364 448 3906265 SGTC_1350 1495-0454 146 µM 0.207089629693788 0.393263088406649 no 1285 0.417969930428992 466 1069057 SGTC_672 1441-0018 53.7 µM 0.206714445745375 0.393418072680256 no 1286 0.418116437496458 426 251141 SGTC_956 1185-0240 191 µM 0.206475312825624 0.393516864617489 no 1287 0.418209823388905 439 1416193 SGTC_1521 st012942 49.4 µM 0.206305905094449 0.393586855441469 no 1288 0.418275983077488 457 24207259 SGTC_1012 4112-3522 18 µM 0.205735028826496 0.393822738342296 no 1289 0.418498947391089 442 3112398 SGTC_2952 9073731 13.78 µM 0.205265689839702 0.394016695791245 no 1290 0.418682274411137 413 16457353 SGTC_1789 tunicamycin 25 nM 0.204812157452969 0.394204146035353 no 1291 0.418859444045625 469 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_187 1488-2104 32.728 µM 0.20469904991166 0.394250898525926 no 1292 0.418903631375643 459 2852859 SGTC_3077 9117319 49.47 µM 0.202933926866778 0.394980701172594 no 1293 0.419593338081086 469 17154678 SGTC_1774 st048371 48.465 µM 0.202129616726243 0.395313371311661 no 1294 0.419907697451545 457 4242727 SGTC_1511 0906-3109 28.5 µM 0.201000093686813 0.395780681302422 no 1295 0.420349250405549 436 2882180 SGTC_2340 7987427 183.45 µM 0.200730642927321 0.395892181520137 no 1296 0.420454598882052 445 2239331 SGTC_1977 st070720 65.3 µM 0.20072387089392 0.395894983934876 no 1297 0.420457246650387 429 682188 SGTC_2906 7926292 26.41 µM 0.200676541850216 0.395914569872962 no 1298 0.420475751730945 461 2966319 SGTC_1606 st000094 49.2 µM 0.19878432988457 0.396697829126328 no 1299 0.421215727155787 461 1242210 SGTC_1939 st074455 53.6 µM 0.197484761370112 0.39723601222496 no 1300 0.421724102644983 483 1644229 SGTC_1089 terbinafine 2.25 µM 0.197235285043303 0.397339348896103 no 1301 0.421821709722183 445 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_2139 5578692 56.4705 µM 0.197227811303236 0.397342444737594 no 1302 0.421824633881064 451 650991 YMR113W FOL3 SGTC_2985 9022375 71.43 µM 0.197125643472089 0.397384766286633 no 1303 0.421864608271099 432 4939335 SGTC_87 0100-0052 35.5 µM 0.195883310156358 0.397899481443205 no 1304 0.422350750385156 464 200187 YGR083C | YDR527W GCD2 | RBA50 SGTC_2184 6075246 200 µM 0.195854939212484 0.397911237980703 no 1305 0.422361853710324 467 2267320 SGTC_740 k014-0057 261 µM 0.194989287008473 0.398269997126672 no 1306 0.422700667191017 482 4012779 SGTC_448 monastrol 171 µM 0.194520895107161 0.398464152397324 no 1307 0.422884018132008 469 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity SGTC_2350 9023895 38.85 µM 0.19447478229055 0.39848326819187 no 1308 0.422902069792798 466 2997209 SGTC_2400 5203494 178.7 µM 0.194170106306152 0.398609575933099 no 1309 0.42302134455081 451 6777674 SGTC_1987 st072290 61.9 µM 0.19377963522379 0.398771466773064 no 1310 0.423174216746361 470 54697379 SGTC_2873 9040596 71.43 µM 0.193470871419215 0.39889949378939 no 1311 0.4232951081548 474 6463863 SGTC_2189 6047310 154.431 µM 0.193095391290153 0.399055198976764 no 1312 0.423442130977016 489 711535 SGTC_3102 9121669 49.47 µM 0.192746677489806 0.399199819012534 no 1313 0.423578682735888 469 41905072 SGTC_523 1934-0222 13.7 µM 0.192727519988704 0.399207764492076 no 1314 0.423586184828627 482 1361595 SGTC_2172 5754775 163.918 µM 0.191779136928892 0.399601153845857 no 1315 0.423957606965769 474 2263357 SGTC_1331 1472-0049 76.2 µM 0.191535387446297 0.399702277630505 no 1316 0.42405307927011 485 24051409 SGTC_2522 biochanin a 4.94 µM 0.190432696643639 0.400159832384102 no 1317 0.424485039110475 465 5280373 A possible chelator. SGTC_794 k038-0031 316 µM 0.188962588768602 0.400770057701059 no 1318 0.425061069168623 460 6624242 SGTC_1383 3049-0032 20.7 µM 0.188629023929838 0.400908550499289 no 1319 0.425191791674354 481 712864 SGTC_2178 5812956 200 µM 0.188567899481118 0.400933930112233 no 1320 0.42521574695308 470 5403383 SGTC_2900 5328528 85.29 µM 0.187753152538521 0.401272262820459 no 1321 0.425535080709269 479 795359 SGTC_2998 9066762 71.4286 µM 0.187564145569896 0.401350760651012 no 1322 0.425609167515767 473 4945196 SGTC_156 3474-0145 5.642 µM 0.187083573438842 0.401550368411664 no 1323 0.425797553634024 464 2265471 SGTC_1005 4092-0690 4.4 µM 0.187053991549438 0.4015626562202 no 1324 0.425809150401944 452 1529343 SGTC_1226 3909-7979 35.4 µM 0.186973710871314 0.40159600392486 no 1325 0.425840622561995 478 6615510 SGTC_2806 7952793 58.44 µM 0.186905088079574 0.401624509640718 no 1326 0.425867524895164 439 2972490 SGTC_1574 spiramycin 23.7 µM 0.186016022007505 0.401993872473632 no 1327 0.426216098432954 463 6419898 An antibiotic and protein synthesis inhibitor. SGTC_2347 9049783 174.81 µM 0.18488508464151 0.402463847302523 no 1328 0.426659585019495 466 6467988 YPL169C MEX67 SGTC_950 1165-0508 94.1 µM 0.184098761920932 0.402790696455333 no 1329 0.426967988862023 449 6148369 SGTC_1792 st045773 43.6 µM 0.183449805882529 0.403060497872357 no 1330 0.427222549719512 457 2919270 SGTC_1477 0139-0234 16 µM 0.183362213802534 0.403096917540509 no 1331 0.427256911096345 459 620880 SGTC_881 0833-0569 170 µM 0.182935650486679 0.403274289128766 no 1332 0.427424254917324 423 5418700 SGTC_676 falcarinol 140 µM 0.181701844182897 0.403787436675336 no 1333 0.427908359308963 472 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer. SGTC_975 1335-0046 28.5 µM 0.18154305575213 0.40385348979877 no 1334 0.427970670485019 462 16486740 SGTC_1830 st055982 50.3 µM 0.18131240061595 0.403949443059228 no 1335 0.428061186530436 478 455313 An antimicrobial agent. SGTC_2991 9074669 71.4286 µM 0.181190988461232 0.403999953218906 no 1336 0.428108833849845 481 17333109 SGTC_2039 Aminomethylbenzodioxan 200 µM 0.179674366711929 0.404631036254612 no 1337 0.428704109160492 459 15053 SGTC_3029 9088683 49.47 µM 0.179539345485178 0.40468723213077 no 1338 0.428757112989478 438 25236615 SGTC_2543 pimpinellin 60.67 µM 0.178130907586892 0.405273541424908 no 1339 0.429310084720669 474 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo. SGTC_12 0849-0099 9.267 µM 0.177611004052483 0.4054900224332 no 1340 0.429514240984757 481 6071388 SGTC_2369 9071472 200 µM 0.177111178412183 0.405698170530794 no 1341 0.429710530815756 451 17296037 SGTC_1500 4488-1866 171 µM 0.176814576636934 0.405821700405168 no 1342 0.429827019477974 494 2900003 SGTC_1133 3473-0247 50 µM 0.175993429332738 0.406163743953013 no 1343 0.430149552255643 452 711311 SGTC_302 1094-0063 18.9 µM 0.175262659009629 0.406468201807584 no 1344 0.430436625690953 472 5440289 SGTC_825 1988-2224 89.6 µM 0.174909471276816 0.406615369252984 no 1345 0.430575383999634 457 1180859 SGTC_2776 terbinafine 19.92 µM 0.174563638445127 0.406759484815139 no 1346 0.430711261064626 455 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_1248 0469-0687 58.6 µM 0.174019766585688 0.406986152799372 no 1347 0.43092496387701 461 4017482 SGTC_2975 9084847 53.72 µM 0.173918853309297 0.407028213578251 no 1348 0.430964617816683 432 27211724 SGTC_2792 7535235 81.82 µM 0.17221574629449 0.407738232077439 no 1349 0.431633959536793 442 1281891 SGTC_392 N-ethylmaleimide 8.33 µM 0.171507893685029 0.408033422312966 no 1350 0.431912212070852 450 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides. SGTC_2406 ethylparaben 405.7 µM 0.17045580397021 0.408472263473584 no 1351 0.432325844486956 419 8434 A possible steroid mimic. SGTC_790 1575-0012 79.1 µM 0.170140899258473 0.408603636929073 no 1352 0.432449664721107 489 378741 YLR208W SEC13 SGTC_3097 9117246 49.47 µM 0.168662989965632 0.409220335187149 no 1353 0.43303086568901 475 16423892 SGTC_2986 9022445 71.43 µM 0.168408303852356 0.409326632709925 no 1354 0.433131037937653 490 6459286 SGTC_2321 7390090 138.78 µM 0.168246696208394 0.409394085829729 no 1355 0.433194603117823 459 649046 SGTC_1202 1988-0068 29.6 µM 0.168158897215927 0.409430733215774 no 1356 0.433229137844956 467 2850480 SGTC_689 0833-0039 98 µM 0.168039696678342 0.409480488904337 no 1357 0.433276024825847 490 5374726 SGTC_1281 0884-0031 11.8 µM 0.167110389524603 0.409868442435658 no 1358 0.433641595654773 451 1548255 SGTC_2225 6654152 15.4 µM 0.1660221825806 0.410322843276559 no 1359 0.434069746626135 475 97582 YGR029W | YLR033W ERV1 | RSC58 SGTC_3306 9127676 59.7925 µM 0.165808784547237 0.41041196569552 no 1360 0.434153716376073 439 41905287 SGTC_246 cycloheximide 667 µM 0.165056538291321 0.410726166689057 no 1361 0.434449740573619 468 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells. SGTC_2932 9016711 44.54 µM 0.16488547737186 0.410797624048576 no 1362 0.434517061659283 458 7117328 SGTC_3200 9114385 49.47 µM 0.16449584872687 0.410960394856195 no 1363 0.434670407236119 442 17018030 YLR208W SEC13 SGTC_2770 toltrazuril 17.5 µM 0.164372824212321 0.411011792619872 no 1364 0.43471882785735 470 68591 Kills coccidiodes. SGTC_280 3448-3607 3.04 µM 0.164138303786917 0.41110977590396 no 1365 0.434811134324477 471 626179 SGTC_1791 st048313 56.1 µM 0.163940657593945 0.411192357338135 no 1366 0.434888929974529 481 1204976 SGTC_1664 st014217 9.02 µM 0.162825410810616 0.411658408489474 no 1367 0.435327950162449 483 3982782 SGTC_89 0302-0250 142.109 µM 0.159913747741268 0.412875751131275 no 1368 0.436474509378768 491 4203518 YLR208W SEC13 SGTC_1446 4239-0190 62 µM 0.157078667531256 0.414061880836919 no 1369 0.437591424853944 488 1340085 SGTC_3093 9117344 49.47 µM 0.154838466801308 0.414999682529761 no 1370 0.438474332388602 444 24824913 SGTC_1841 st054148 70 µM 0.154271128863741 0.415237260890148 no 1371 0.4386979803013 470 675442 SGTC_3147 9097027 49.47 µM 0.153752293405203 0.415454555495957 no 1372 0.438902525393225 473 25236841 SGTC_3160 9100216 49.47 µM 0.151676790439017 0.416324059384767 no 1373 0.439720931946862 487 17191039 SGTC_341 1486-1430 230 µM 0.151545728716747 0.416378979715383 no 1374 0.439772620526155 482 2054753 YPL210C SRP72 SGTC_2511 berberine 10.47 µM 0.151058277118965 0.416583256594737 no 1375 0.439964872390913 455 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_2948 9070189 9.45 µM 0.150234182393622 0.416928662095053 no 1376 0.440289929139171 480 6473636 YDL196W YDL196W SGTC_679 0422-0091 41.4 µM 0.148347713803391 0.417719584835581 no 1377 0.441034180864224 492 627384 YHR062C RPP1 SGTC_332 4112-0506 40.9 µM 0.146156596105013 0.418638652837676 no 1378 0.441898884412727 497 2790355 SGTC_1194 1488-0194 225 µM 0.145659916026603 0.418847048082232 no 1379 0.44209493308583 467 1391452 SGTC_2865 9030313 51.95 µM 0.145415378207862 0.418949658752767 no 1380 0.442191461830462 495 42562754 SGTC_3031 9088762 49.47 µM 0.144420136094435 0.419367329746732 no 1381 0.442584358592702 452 205253 SGTC_483 fpl-64176 144 µM 0.143976568570964 0.419553510023687 no 1382 0.442759486204397 486 3423 SGTC_1878 temozolomide 1 mM 0.141972713827385 0.42039481943923 no 1383 0.443550779274705 493 5394 DNA alkylating agent. SGTC_2644 guaiazulene 100 µM 0.141002851649642 0.420802142610697 no 1384 0.443933844780765 488 3515 A coloring agent. SGTC_1811 st050069 61.5 µM 0.140963561370282 0.420818645550826 no 1385 0.443949364330125 504 3877702 SGTC_1080 nisoldipine 24.4 µM 0.140510738139066 0.421008853131826 no 1386 0.444128234425287 497 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class. SGTC_615 k087-0205 167 µM 0.139479718517835 0.421441999783075 no 1387 0.444535540775892 488 9642773 SGTC_2270 7924575 90.91 µM 0.138858345410431 0.421703093804425 no 1388 0.444781043774115 473 1262135 SGTC_3061 glucosamine 200 µM 0.138779260907843 0.4217363266986 no 1389 0.444812291389647 499 91431 and experimental redox chemotherapeutic SGTC_2268 7933382 153.85 µM 0.138017959309826 0.422056269374867 no 1390 0.445113111953268 424 935025 YOR257W CDC31 SGTC_2155 5570423 76 µM 0.137310861329071 0.422353478664234 no 1391 0.445392542827985 478 797402 SGTC_916 4466-0038 42 nM 0.137304076587342 0.422356330659219 no 1392 0.445395224152847 493 5722064 YGL116W CDC20 SGTC_2433 5607874 27.82 µM 0.137284580039239 0.422364526138628 no 1393 0.445402929187992 500 2252428 SGTC_3305 9127027 53.8275 µM 0.137095040755806 0.422444201752408 no 1394 0.445477836180701 466 41905295 SGTC_2012 4023501 200 µM 0.13635581266372 0.422754977402854 no 1395 0.445770001862935 488 3477460 SGTC_3279 9140807 49.47 µM 0.135770142479291 0.423001230592541 no 1396 0.446001497653894 492 45595718 SGTC_1717 st033143 58.0435 µM 0.134748216259992 0.423430985708631 no 1397 0.446405474868535 491 674616 SGTC_3065 9113888 49.47 µM 0.130188580699535 0.425349572374154 no 1398 0.448208614484911 476 16648368 SGTC_841 0251-0215 91.2 µM 0.129149246342418 0.425787148887212 no 1399 0.448619777659827 502 3888614 SGTC_3025 9087895 49.47 µM 0.12824518133294 0.426167849181403 no 1400 0.448977472856506 478 17173641 SGTC_839 0122-0028 230 µM 0.127245230560415 0.426589006951326 no 1401 0.449373153748177 501 759448 SGTC_692 k241-0027 77.8 µM 0.126101417206593 0.427070859173518 no 1402 0.449825822829642 491 3600480 SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM 0.125481368001829 0.427332111738935 no 1403 0.450071237313317 452 4174840 SGTC_992 3909-8734 162 µM 0.12528795761722 0.427413610119381 no 1404 0.450147792745718 476 4288319 SGTC_292 k038-0015 474 µM 0.123720692418004 0.42807413109427 no 1405 0.450768213677984 471 46368540 SGTC_3319 9138450 16.7555 µM 0.123679346240096 0.428091559100559 no 1406 0.450784582699291 502 2029690 SGTC_2925 9010536 32.5 µM 0.122789876631247 0.428466517194685 no 1407 0.451136745436216 475 2994177 SGTC_1926 methyl fluorone black 53.6 µM 0.121985278299305 0.428805753238558 no 1408 0.451455338704126 488 72721 Reacts with homocysteine. SGTC_2624 nerol 100 µM 0.121192158609316 0.429140201122817 no 1409 0.451769417430727 485 637566 A natural product oil. SGTC_2967 9089538 49.85 µM 0.120136698625009 0.42958535323794 no 1410 0.452187430803319 499 728216 SGTC_1333 1482-0047 286 µM 0.118568278739117 0.430247017198498 no 1411 0.452808698962412 511 3811116 SGTC_395 anisomycin 6.25 µM 0.118501042832161 0.43027538617425 no 1412 0.452835334429271 494 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_2726 cimetidine 79.27 µM 0.118204727424128 0.430400415391492 no 1413 0.452952722139047 506 2756 A P450 inhibitor, histamine H2-receptor antagonist. SGTC_1603 st002045 67.8 µM 0.118014991412225 0.430480477482466 no 1414 0.453027889731817 495 5887985 SGTC_970 1315-0089 19.5 µM 0.117695355673777 0.430615359264523 no 1415 0.453154523419746 491 6811083 YLR033W RSC58 SGTC_1296 1068-0102 11.9 µM 0.117376376213216 0.430749972176682 no 1416 0.453280901852029 499 767053 SGTC_528 3492-0019 172 µM 0.117247803536722 0.430804233565283 no 1417 0.453331843189407 494 2869262 SGTC_2860 9025725 38.96 µM 0.115811413273748 0.431410520391037 no 1418 0.453901002450102 503 40546248 SGTC_2368 9071271 200 µM 0.115563210454375 0.431515300885295 no 1419 0.453999360650311 491 27209959 SGTC_119 0121-0043 24.815 µM 0.115331759898279 0.431613013640964 no 1420 0.454091082779691 488 1092378 SGTC_2664 lyso-paf C-16 73.48 µM 0.1149536626504 0.431772646037057 no 1421 0.454240925164092 478 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_803 4488-1585 147 µM 0.114670798680112 0.431892078296496 no 1422 0.454353030244691 501 747204 SGTC_3039 9090270 49.47 µM 0.11427734785492 0.432058213447863 no 1423 0.454508969321236 499 17173750 SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM 0.113402285686247 0.43242775268781 no 1424 0.454855813843574 482 115019 SGTC_2277 7947813 106.88 µM 0.112275049800883 0.432903872111428 no 1425 0.455302662038371 502 1246798 SGTC_2606 farnesol 9.78 µM 0.111433008834093 0.433259595136044 no 1426 0.455636492893485 513 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_1475 4092-1048 11.7 µM 0.111288087267715 0.433320823199375 no 1427 0.455693950853754 479 2881759 SGTC_1 0258-0098 57.368 µM 0.110947804342576 0.433464595974733 no 1428 0.455828868594839 466 6790032 YDR047W HEM12 SGTC_1746 st038117 42 µM 0.110517396468445 0.433646460008779 no 1429 0.45599952699666 505 2898218 SGTC_2713 st079149 53.4 µM 0.109409792300365 0.434114530268732 no 1430 0.456438733621827 497 3103253 SGTC_2881 9058953 51.95 µM 0.109245353971807 0.434184029314543 no 1431 0.456503944141728 496 17122249 SGTC_1557 sumaresinolic acid 42.3 µM 0.108855786602325 0.434348686150352 no 1432 0.456658437678376 476 9982268 A natural terpine and antifungal of unknown mechanisn. SGTC_2646 retinol 96.75 µM 0.10817503536012 0.43463644379963 no 1433 0.456928423813643 493 445354 A vitamin A analog and teratogen. SGTC_1485 3909-9022 254 µM 0.107420775987016 0.434955314213896 no 1434 0.457227586508136 506 714516 SGTC_1654 st012436 41.8 µM 0.102489091447913 0.437041264793395 no 1435 0.459184235509172 498 4323132 SGTC_3188 9110789 49.47 µM 0.101851033526193 0.437311272824566 no 1436 0.459437458669048 483 849217 SGTC_2148 5546263 113.568 µM 0.101807616603845 0.437329646698195 no 1437 0.45945468994569 484 792097 SGTC_1583 clindamycin 39.6 µM 0.101789038332948 0.437337508991884 no 1438 0.459462063299636 499 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis. SGTC_2193 5925765 200 µM 0.101051657709541 0.437649587209059 no 1439 0.459754726543427 483 877370 SGTC_244 nsc-207895 1.295 µM 0.10092238236184 0.43770430382306 no 1440 0.459806037632234 489 42640 SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM 0.100407983193052 0.437922038336912 no 1441 0.460010216063252 511 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding. SGTC_1779 st039427 55 µM 0.0981643464518257 0.438871942233127 no 1442 0.460900896549058 495 1124498 SGTC_658 3253-0951 102 µM 0.0978544244837082 0.439003183832465 no 1443 0.461023945111377 500 1184878 SGTC_887 0885-0007 9.62 µM 0.096649551208266 0.439513470994768 no 1444 0.461502352241724 505 5719458 SGTC_2302 7771753 200 µM 0.0963357742478652 0.439646378144717 no 1445 0.461626949731771 500 2203047 SGTC_2208 7283366 200 µM 0.0962227835849476 0.439694239497925 no 1446 0.461671818043917 504 898663 SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM 0.0962081656276859 0.439700431536054 no 1447 0.461677622834159 496 4000243 SGTC_1172 0370-0043 85 µM 0.0956765107172724 0.439925645892648 no 1448 0.461888748515693 495 376585 SGTC_1335 1486-0900 202 µM 0.095086816167087 0.440175469160145 no 1449 0.4621229349001 499 X1335 SGTC_2662 daunorubicin 22.37 µM 0.0949251634170375 0.440243957284389 no 1450 0.462187134624193 497 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_2454 5-benzylidenerhodanine 10.36 µM 0.0943526588763567 0.440486527139988 no 1451 0.462414510356657 515 1273210 SGTC_2899 9053889 58.44 µM 0.0938173600134529 0.440713353177829 no 1452 0.462627120605867 514 6470052 SGTC_1756 st041558 35.5 µM 0.0933498426144092 0.440911473605534 no 1453 0.462812818119255 489 3955792 SGTC_869 0564-0080 44.1 µM 0.0929506099411734 0.441080668639731 no 1454 0.462971399414528 468 6843321 SGTC_723 4182-0001 115 µM 0.091327360039954 0.441768713312881 no 1455 0.46361623932953 497 744821 YLR208W SEC13 SGTC_2847 9005661 71.43 µM 0.0911278733657675 0.441853281619013 no 1456 0.463695492519519 520 2991449 SGTC_225 nsc-122657 1.016 µM 0.0905430388033928 0.442101225562921 no 1457 0.463927847181661 508 275685 SGTC_1604 st002052 72.4 µM 0.0879872407308105 0.443185035635426 no 1458 0.464943408615403 503 6254834 YHR062C RPP1 SGTC_1496 4469-0713 57.4 µM 0.0870988550230495 0.443561863904238 no 1459 0.465296467743931 517 746691 SGTC_266 formosanin C 406 nM 0.0864264193261472 0.443847126200188 no 1460 0.465563722957897 508 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1 SGTC_310 1273-0058 1.06 µM 0.0857045319473211 0.444153399390241 no 1461 0.465850649707097 496 2734232 SGTC_2780 5215298 71.43 µM 0.085312767090517 0.444319626371754 no 1462 0.46600637093384 506 2834131 SGTC_762 1165-0429 115 µM 0.0851848373901822 0.444373909442852 no 1463 0.466057222386208 516 5967793 SGTC_1955 wogonin 32.4 µM 0.0849888031342649 0.444457092631522 no 1464 0.466135146153063 502 5281703 A flavanone. SGTC_2256 7954252 200 µM 0.0837302199403112 0.444991205182477 no 1465 0.466635464733154 499 2972920 SGTC_1143 3454-2408 5.08 µM 0.0834712590114812 0.445101114417438 no 1466 0.466738414803686 512 X1143 SGTC_1909 st060837 51.5 µM 0.0831635917474815 0.445231701275253 no 1467 0.466860730998603 506 678937 SGTC_2393 9031399 185.94 µM 0.0824153356766144 0.445549317229637 no 1468 0.467158220714536 507 1526623 YDL150W RPC53 SGTC_2386 9075165 157.42 µM 0.0808482583276739 0.446214615311962 no 1469 0.467781314528905 508 16452277 SGTC_428 3448-4153 16.5 µM 0.0798852930304351 0.44662351464346 no 1470 0.468164243452602 491 3834874 SGTC_2660 2',4'-dihydroxychalcone 17.14 µM 0.0786495451266486 0.44714832743817 no 1471 0.468655689124208 510 5357218 A potent inhibitor of glutathione S-transferases. SGTC_1191 1487-1166 10.6 µM 0.0785590361475484 0.447186769566545 no 1472 0.468691685606212 521 3955771 SGTC_2943 9068529 45.32 µM 0.0785169080366027 0.447204662924572 no 1473 0.468708440537103 527 3270634 SGTC_749 1000-0129 128 µM 0.0778205341192373 0.447500454079933 no 1474 0.46898540605821 506 708470 SGTC_1615 st002656 86.5 µM 0.0774176525497893 0.447671595035172 no 1475 0.469145649111342 506 1584458 SGTC_3028 9087778 49.47 µM 0.0774127086568987 0.447673695222969 no 1476 0.469147615537903 516 17217395 SGTC_2 0422-0095 29 µM 0.0754165028821299 0.448521811598097 no 1477 0.46994166460038 481 6790840 SGTC_930 2810-3379 265 µM 0.075320444306386 0.448562629413605 no 1478 0.469979877740261 502 1015764 SGTC_3106 9121286 49.47 µM 0.0739838036052375 0.449130659517751 no 1479 0.47051163639443 500 15943471 SGTC_195 4234-0266 16.654 µM 0.0735271890720863 0.449324730234146 no 1480 0.470693304437807 525 2303354 SGTC_832 4083-0019 164 µM 0.0730676016707751 0.449520076723412 no 1481 0.470876161421471 516 1990758 SGTC_2697 mebhydrolin 72.4 µM 0.0721069541722872 0.449928437028165 no 1482 0.471258396002571 516 22530 H1 Histamine receptor antagonist. YIL048W NEO1 SGTC_2981 9013952 38.96 µM 0.0718368061458395 0.450043283447003 no 1483 0.471365890702447 521 2996344 SGTC_2318 6029776 164 µM 0.0711772793604596 0.450323681691348 no 1484 0.471628331994106 515 818325 SGTC_3213 9129884 49.47 µM 0.0709047919487669 0.450439537140054 no 1485 0.47173676477681 496 17190742 SGTC_1411 3909-8223 150 µM 0.0707281133490907 0.450514659118983 no 1486 0.471807072822588 516 X1411 SGTC_3198 9112019 49.47 µM 0.0697371012195181 0.450936060380708 no 1487 0.472201455574973 521 45595555 SGTC_2019 4016004 108 µM 0.0695143643630494 0.451030780869136 no 1488 0.472290099601915 504 45595336 SGTC_717 1532-0246 73.2 µM 0.069385097797455 0.451085753707215 no 1489 0.472341545282534 498 9561992 SGTC_1815 st051655 58.2 µM 0.0693393123385034 0.451105224988918 no 1490 0.472359767151413 516 5984156 SGTC_1836 st055642 81 µM 0.0675437675756255 0.45186891252756 no 1491 0.473074410035313 522 8571 SGTC_1305 1181-0477 144 µM 0.0674489561463981 0.451909243040964 no 1492 0.473112148261972 515 6252086 SGTC_656 4090-1979 187 µM 0.0673854199995548 0.451936270075332 no 1493 0.473137437980063 517 22330961 SGTC_3136 9095672 49.47 µM 0.066371528594241 0.452367589706928 no 1494 0.473541018548635 519 17217380 SGTC_3321 9137793 26.8275 µM 0.065936516298218 0.452552665590349 no 1495 0.473714184013034 520 4904192 SGTC_1101 ebselen 5.29 µM 0.063389436880791 0.453636525560792 no 1496 0.474728199241858 519 3194 A potent scavenger of hydrogen peroxide and hydroperoxides. SGTC_965 1291-5240 308 µM 0.0619583435992912 0.454245651476102 no 1497 0.475298002612314 514 2834598 SGTC_1376 2910-0861 41.3 µM 0.0606373555416044 0.454808008118473 no 1498 0.475824011413717 514 1112859 SGTC_95 0471-0001 561.058 µM 0.0590507348115137 0.455483566650854 no 1499 0.476455849023082 524 4015405 SGTC_508 roscovitine 141 µM 0.0589720692266206 0.455517064604309 no 1500 0.476487177455171 524 160355 A CDKinase inhibitor. SGTC_846 0335-0850 148 µM 0.0581748368767976 0.45585656570404 no 1501 0.476804682015834 510 6819598 SGTC_298 1391-0729 10 µM 0.0581260351825239 0.45587734893691 no 1502 0.476824118185794 515 3237558 SGTC_3204 9114183 49.47 µM 0.0577934209961632 0.456019002930276 no 1503 0.476956589353023 512 17027248 SGTC_3221 9128209 49.47 µM 0.0574955621761566 0.456145860025992 no 1504 0.477075220566568 521 16460723 SGTC_2232 chlorophetanol 41.5365 µM 0.0573512121271583 0.456207339847995 no 1505 0.477132713036917 525 15907 An antifungal of unknown mechanism. YFR051C RET2 SGTC_2965 9082772 38.63 µM 0.0564311887105359 0.456599209637738 no 1506 0.477499155767903 506 16459634 SGTC_1943 st076331 65.2 µM 0.055358762159021 0.457056046448021 no 1507 0.477926324229856 530 24208415 SGTC_713 1488-1073 324 µM 0.0546362059880282 0.457363876029747 no 1508 0.478214146809029 535 3312542 SGTC_2841 9004761 38.96 µM 0.0541991040059079 0.457550106398178 no 1509 0.478388267268385 520 2991039 SGTC_2199 6590217 200 µM 0.0538353660427119 0.457705086618697 no 1510 0.478533166168337 507 703109 SGTC_1919 st067113 52.3 µM 0.0530238219777202 0.45805088967056 no 1511 0.47885646360784 527 1268243 SGTC_664 1222-0054 14.9 µM 0.0512865659564178 0.458791249708613 no 1512 0.479548586415398 523 6813991 SGTC_850 0388-0143 75.9 µM 0.0512625034834539 0.458801505334332 no 1513 0.479558173342558 527 67273 SGTC_2137 5261020 140 µM 0.050039604625014 0.459322750940013 no 1514 0.480045413955449 509 763655 SGTC_16 erodoxin 22.806 µM 0.0496831892938934 0.459474681794749 no 1515 0.480187426457075 519 3967339 Erodoxin inhibits Ero1. YML130C ERO1 SGTC_337 1315-0038 354 µM 0.0494910918779964 0.459556570527902 no 1516 0.480263968076742 526 1626437 SGTC_3094 9117742 49.47 µM 0.0488730056161285 0.459820064619243 no 1517 0.480510250772031 528 17149698 SGTC_1153 4055-0057 267 µM 0.0487602538901886 0.459868133301464 no 1518 0.480555178637792 533 882706 SGTC_1725 st036284 20.55 µM 0.048450483363936 0.460000198696424 no 1519 0.480678613305212 487 707914 SGTC_512 prima-1 270 µM 0.048204286137468 0.460105163844601 no 1520 0.480776717158457 503 322968 A re-activator of the apoptotic function of mutant p53. SGTC_285 1486-1325 46 µM 0.0475978425530787 0.460363730350982 no 1521 0.481018375737902 516 22310230 SGTC_8 0354-0001 70 µM 0.0471614578492336 0.460549800026576 no 1522 0.481192272751103 526 4993152 SGTC_653 0203-0016 55.2 µM 0.0461120229362316 0.460997302910306 no 1523 0.481610481642725 526 295302 SGTC_3035 9091303 49.47 µM 0.0457013302560105 0.461172445076684 no 1524 0.481774151763988 530 25237002 SGTC_2821 7996764 71.43 µM 0.045185683252088 0.461392356255417 no 1525 0.48197965285234 519 2987135 SGTC_2254 7938975 95.19 µM 0.0450626660456425 0.461444821913799 no 1526 0.482028679677766 515 2969277 SGTC_377 3970-0964 33.1 µM 0.04298400757959 0.462331450543204 no 1527 0.482857141086738 526 16481235 SGTC_2751 anetholtrithion 17.25 µM 0.0418380245442117 0.462820337184794 no 1528 0.483313911167556 522 2194 A chloretic substance that stimulates the liver to produce bile. SGTC_559 1550-0661 158 µM 0.0415670694631484 0.462935937289826 no 1529 0.483421912651487 525 5830875 SGTC_1146 3579-1023 7 µM 0.0412779800583641 0.463059277662478 no 1530 0.483537143736832 522 X1146 SGTC_2592 piperlongumine 83.33 µM 0.0411111210697987 0.463130469885414 no 1531 0.483603654384225 523 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_1073 triclabendazole 3.09 µM 0.0393642319532599 0.463875869809018 no 1532 0.484299998280313 516 50248 An antihelmetic and likely tubulin inhibitor. SGTC_2491 paeonol 100 µM 0.0384651841415286 0.464259544309868 no 1533 0.484658394979862 530 11092 Increases levels of cortical cytochrome oxidase. SGTC_756 0508-1999 28.3 µM 0.038317309154689 0.464322654114787 no 1534 0.484717345105325 532 6753853 SGTC_2001 4023502 57.655 µM 0.0374657854993835 0.464686083174644 no 1535 0.485056810099727 528 108941 YCR052W RSC6 SGTC_829 1635-0120 117 µM 0.0374430068279444 0.464695805484503 no 1536 0.485065891103061 526 285054 SGTC_1794 st048918 76.9 µM 0.0368591857807149 0.464944997041542 no 1537 0.485298641322863 531 672303 SGTC_2315 7733312 200 µM 0.0362947696240603 0.46518591910693 no 1538 0.485523660214545 520 726316 SGTC_330 1488-0319 80.1 µM 0.0358057997005273 0.465394647130543 no 1539 0.485718604270887 539 6846614 SGTC_1956 st077085 54 µM 0.0352561327885646 0.465629296419884 no 1540 0.485937751264768 540 24208685 SGTC_2569 tetrandrine 100 µM 0.035208809148565 0.465649499139026 no 1541 0.485956618951505 525 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_421 streptovitacin 30 mM 0.0351125815011567 0.46569057951772 no 1542 0.485994984506076 511 91467 include heat shock SGTC_2818 7996756 12.99 µM 0.035017110700506 0.465731337153577 no 1543 0.486033048437162 536 2241621 SGTC_1097 itavastatin 7.23 µM 0.0345256315693196 0.465941161199172 no 1544 0.486229001746241 534 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49 SGTC_2879 9041815 71.43 µM 0.0344909850558314 0.465955952971753 no 1545 0.486242815478033 536 4942971 SGTC_1300 1094-0077 113 µM 0.0332402704749118 0.466489956811558 no 1546 0.486741492329146 528 5532636 SGTC_2714 st079313 56.9 µM 0.0327972396869945 0.46667912731092 no 1547 0.486918139720406 529 2939799 SGTC_1137 ixabepilone 100 µM 0.0323514608741572 0.466869478791787 no 1548 0.487095885408128 537 154225 A novel microtubule stabilizer. SGTC_2686 alizarin 95.37 µM 0.0316399436321051 0.467173318605543 no 1549 0.487379594456046 524 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1 SGTC_1444 4112-3581 28 µM 0.0313416730270416 0.467300695056366 no 1550 0.487498528224758 532 2877249 SGTC_349 k015-0014 24 µM 0.0305969078440529 0.467618761591081 no 1551 0.487795504089887 527 2196908 SGTC_3170 9103054 49.47 µM 0.0305670623287541 0.46763150813421 no 1552 0.487807405161233 526 16432970 SGTC_978 1416-0512 87.4 µM 0.0291230378391638 0.468248267345788 no 1553 0.488383231025116 534 6814003 SGTC_1788 fluconazole 20 µM 0.0256304604644425 0.469740298921459 no 1554 0.489776045054436 543 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11 SGTC_2501 sodium tetradecyl sulfate 13.37 µM 0.0255943086461234 0.469755745262744 no 1555 0.489790462813517 538 23665772 A membrane-active detergent. SGTC_17 0960-0276 49.807 µM 0.0255240669780597 0.469785757072146 no 1556 0.489818476033126 536 6821114 SGTC_1989 st071868 50.2 µM 0.0254066204840713 0.469835938236934 no 1557 0.489865315215549 539 16414057 SGTC_343 4130-2827 29.8 µM 0.0245099975319581 0.470219052540843 no 1558 0.490222904617113 525 1118244 SGTC_1745 st081495 74 µM 0.0244638094439888 0.470238788807155 no 1559 0.490241325474774 532 13842402 YBL026W LSM2 SGTC_1625 st003711 30.1 µM 0.0239196877490166 0.470471298632874 no 1560 0.490458335111178 533 24207034 YER133W GLC7 SGTC_1429 4049-0205 9.46 µM 0.0212556052832156 0.471609837340974 no 1561 0.4915208788407 530 22774478 SGTC_2451 5856223 45.7 µM 0.0211015194440091 0.471675695603487 no 1562 0.491582336412336 532 2179896 SGTC_2408 sulbentine 18.36 µM 0.020595289975419 0.471892070008989 no 1563 0.49178424886279 512 67686 An antifungal agent of unknown mechanism. YDL205C HEM3 SGTC_2848 9016370 25.97 µM 0.020593443121301 0.471892859413192 no 1564 0.491784985494754 544 7894410 SGTC_1561 5-methoxyflavone 52.9 µM 0.0193091426437187 0.472441836856963 no 1565 0.49229724525711 539 94525 SGTC_3046 9092212 49.47 µM 0.0192269289948522 0.472476981080392 no 1566 0.492330037669885 537 25236637 SGTC_2578 7,8-dihydroxyflavone 64.44 µM 0.019063800213359 0.472546715079026 no 1567 0.492395104711809 538 1880 Intensifies effect of antibiotics on Staphylococcus aureus. SGTC_1339 1486-1321 22.7 µM 0.0178157719508317 0.473080247648881 no 1568 0.492892911279855 535 3469382 SGTC_976 1348-1067 47.6 µM 0.017814896064706 0.473080622107614 no 1569 0.492893260652416 538 5310671 YGL099W LSG1 SGTC_301 4119-0100 24.5 µM 0.0174785170265371 0.47322443258995 no 1570 0.493027435579268 540 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1 SGTC_867 0518-0118 155 µM 0.0166386591168374 0.473583508121616 no 1571 0.493362441652968 537 6848158 SGTC_1554 st069299 38.7 µM 0.0149048080633332 0.474324871906646 no 1572 0.49405406203471 542 24207999 SGTC_347 4534-1311 26.2 µM 0.0145053942487812 0.474495666824299 no 1573 0.494213387864412 542 2862016 SGTC_2670 beta-carotene 100 µM 0.0142623324518261 0.474599605734847 no 1574 0.494310345461164 540 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.) SGTC_2789 5281112 71.43 µM 0.0134234990839537 0.474958323741012 no 1575 0.494644959486048 537 765948 SGTC_2471 5466956 24.79 µM 0.0117519006044474 0.47567322497927 no 1576 0.495311777886906 546 724419 SGTC_3351 9150312 21.596 µM 0.011682707264179 0.475702818959827 no 1577 0.495339380140962 541 4904905 SGTC_1540 guanosine 70.6 µM 0.0116382049560185 0.47572185266074 no 1578 0.49535713278634 544 6802 Guanosine is a purine nucleoside SGTC_2101 5377231 179.231 µM 0.0108202585089222 0.476071699349363 no 1579 0.495683425625394 540 2844213 SGTC_1585 2',4'-dihydroxychalcone 10.4 µM 0.00674577779767818 0.477814678998351 no 1580 0.497308844432733 545 5357218 A potent inhibitor of glutathione S-transferases. SGTC_1042 0350-0096 82 µM 0.00599210474978654 0.47813713244768 no 1581 0.49760951037194 543 3122515 SGTC_590 k048-0076 22.4 µM 0.00553457066531852 0.478332892022928 no 1582 0.497792037029934 544 6832814 SGTC_3062 9077494 49.47 µM 0.00550358394732566 0.478346150124733 no 1583 0.497804398753599 543 16459633 SGTC_1769 st044406 64.4 µM 0.00538920564346434 0.478395088693271 no 1584 0.497850028418179 546 670903 SGTC_393 acivicin 6.25 µM 0.00529292607841439 0.478436283682349 no 1585 0.497888437859545 546 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1 SGTC_2239 6685329 187.64 µM 0.0046735778200517 0.478701288755515 no 1586 0.498135518994272 545 805680 SGTC_1367 1812-0510 76.9 µM 0.00457627194205471 0.478742924592753 no 1587 0.498174338007951 542 1142582 YDR527W RBA50 SGTC_1851 st056236 18.9 µM 0.00415240550580578 0.478924293869286 no 1588 0.498343434638911 545 5393171 SGTC_3073 9114972 49.47 µM 0.00391506758676454 0.479025850897391 no 1589 0.498438117999035 547 41905075 SGTC_3054 9094397 49.47 µM 0.00275530474943537 0.47952213352555 no 1590 0.498900793830868 544 2598354 SGTC_2764 methyldopa 94.69 µM 0.00266774938883282 0.479559601281014 no 1591 0.498935723237669 544 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent. SGTC_1024 4507-0395 26 µM 0.00260013159656115 0.479588537233217 no 1592 0.498962698740335 547 4201836 SGTC_1739 st037196 92.5 µM 0.00245341458845925 0.47965132279883 no 1593 0.499021230171219 546 612214 SGTC_787 4152-0075 138 µM 0.0023921797615478 0.479677527566879 no 1594 0.499045659261004 546 9566539 SGTC_2783 7738165 71.43 µM 0.00229164865377073 0.47972054893485 no 1595 0.499085765260393 547 17201110 SGTC_1431 4049-0260 9.09 µM 0.0013298607247725 0.480132149150456 no 1596 0.499469462486221 547 3854841 SGTC_2305 7443522 69.23 µM 0.000413183975399069 0.480524463616638 no 1597 0.499835163447319 547 5415886 SGTC_2314 7727897 200 µM 0.000370668357538583 0.480542659686562 no 1598 0.499852124723557 546 900724 SGTC_212 3807-4682 38.772 µM -0.000530559011639494 0.480928381452553 no 1599 0.499788337587939 548 3125501 YBL034C STU1 SGTC_2345 9052315 157.45 µM -0.000934791163838517 0.481101397044693 no 1600 0.499627072335712 549 6469265 SGTC_2046 4110841 106 µM -0.00122136557730951 0.481224056051535 no 1601 0.499512745752527 549 44119630 YMR134W ERG29 SGTC_3211 9128781 49.47 µM -0.00173080740590296 0.481442110704626 no 1602 0.499309508091304 549 17194361 SGTC_336 4111-0029 111 µM -0.00182687412328205 0.481483230439112 no 1603 0.499271183076652 551 3131175 SGTC_1314 1222-0010 41.1 µM -0.00230193585609968 0.481686575470949 no 1604 0.499081661271262 550 3526027 SGTC_711 k292-0785 179 µM -0.00230492034944848 0.481687852966134 no 1605 0.499080470633838 551 4146315 SGTC_1355 1499-0035 1.68 µM -0.00256040991954305 0.481797214500459 no 1606 0.498978545343993 550 1548538 SGTC_426 0988-0037 14.6 µM -0.00317395774946771 0.482059847364037 no 1607 0.498733776183521 549 5383008 SGTC_429 1112-0049 25.5 µM -0.00365624271526584 0.482266297834965 no 1608 0.498541373443318 550 2836170 SGTC_2549 cedrol 20.94 µM -0.00515370421315697 0.482907342341856 no 1609 0.497943978590243 550 6708665 A sedative which affects the nervous system. SGTC_2364 9055074 200 µM -0.00571147045774573 0.483146126467236 no 1610 0.497721465339121 551 6470630 SGTC_3030 9087619 49.47 µM -0.00709333383032715 0.483737738928402 no 1611 0.497170192956572 552 25236973 SGTC_2009 4012297 12.05 µM -0.00806173537608316 0.48415235880069 no 1612 0.496783867742028 552 45595307 SGTC_1343 1487-0095 224 µM -0.00843876149222847 0.484313786705081 no 1613 0.496633461203291 553 4560101 YGL055W OLE1 SGTC_1850 st056238 17 µM -0.00896736694827883 0.48454011930483 no 1614 0.496422586126018 550 5393177 SGTC_1250 0485-0349 40.2 µM -0.00900342274801478 0.48455555747172 no 1615 0.496408202523709 557 6842794 YDL195W SEC31 SGTC_249 wiskostatin 11.211 µM -0.00901065228249322 0.484558652975387 no 1616 0.496405318473727 553 2775510 A n-wasp and actin depolymerizer. SGTC_1892 st058411 7.36 µM -0.0100673064261219 0.485011095444131 no 1617 0.495983793657837 553 3934738 SGTC_705 1124-0212 310 µM -0.0120213836442675 0.485847850582663 no 1618 0.495204277303564 552 9554485 SGTC_754 3474-0146 171 µM -0.0125601647961478 0.486078573101945 no 1619 0.494989350959131 553 24762078 SGTC_1373 2887-0003 58.5 µM -0.0126582390520191 0.486120571992688 no 1620 0.494950228102095 557 776948 SGTC_1804 st050076 49.1 µM -0.0141855996224098 0.486774661784672 no 1621 0.494340954334537 551 3895976 SGTC_2895 9054447 58.44 µM -0.0145116408037922 0.486914293082116 no 1622 0.494210896111779 552 2697450 SGTC_3324 9138759 60.749 µM -0.0164035151585179 0.487724543542298 no 1623 0.493456237718188 558 45595710 SGTC_1290 0986-0249 10.2 µM -0.0175664571568424 0.488222632786435 no 1624 0.492992357928647 554 53329 SGTC_143 4032-1194 15.74 µM -0.0177797938572951 0.488314007129847 no 1625 0.492907262189449 557 1806963 SGTC_404 fumagillin 50 µM -0.0193590438982323 0.488990435223376 no 1626 0.492277341257318 554 12015870 A methionine aminopeptidase binder. SGTC_1937 st074714 47.2 µM -0.0228304818712706 0.490477438291154 no 1627 0.490892746670129 570 17250970 SGTC_3348 9149464 3.537 µM -0.0228976219903014 0.490506199376384 no 1628 0.490865968638164 557 1951442 SGTC_3083 9117465 49.47 µM -0.0235729288150724 0.490795486021227 no 1629 0.490596632912669 560 16420915 SGTC_3256 9138902 49.47 µM -0.0240204723163682 0.490987206526613 no 1630 0.490418139435235 559 17228773 SGTC_311 1315-0136 58 µM -0.0244837939926931 0.491185688343883 no 1631 0.49023335518067 567 6759207 SGTC_1168 k815-0004 80.5 µM -0.0251806345700198 0.491484211137283 no 1632 0.489955441716629 557 642433 SGTC_1116 jasmonic acid  1.58368 µM -0.0252101581247345 0.491496858977443 no 1633 0.489943667260239 556 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid. SGTC_2402 5553605 200 µM -0.0255594947918481 0.491646514851537 no 1634 0.489804346989827 563 6758546 SGTC_2258 7960471 200 µM -0.0262394576202173 0.491937814369399 no 1635 0.48953317203872 559 2974708 SGTC_506 n9-isopropylolomoucine 153 µM -0.027567326216728 0.49250669225307 no 1636 0.489003620828924 560 6610355 SGTC_2311 7694451 200 µM -0.0276208334842349 0.492529615858354 no 1637 0.488982282642958 558 2163142 SGTC_757 1066-0008 322 µM -0.0277257391188691 0.492574559644494 no 1638 0.488940447371887 571 6842497 SGTC_3020 9089140 49.47 µM -0.0293861637047852 0.493285932730245 no 1639 0.488278303902141 557 17217859 SGTC_2718 lomofungin 53.02 µM -0.030359777406898 0.49370306658873 no 1640 0.48789006151823 563 5351222 A RNA synthesis inhibitor. SGTC_2460 5552655 174.22 µM -0.0304744402704619 0.493752193067172 no 1641 0.487844338810217 571 5401989 SGTC_539 4859-0462 2.54 µM -0.0306696014050621 0.493835808667829 no 1642 0.487766517158699 565 46499474 YNL221C | YBR257W POP1 | POP4 SGTC_3318 9139014 38.6185 µM -0.0308709787476873 0.493922087848861 no 1643 0.487686217245957 561 16643984 SGTC_652 0437-0092 114 µM -0.0312333032434021 0.494077324798513 no 1644 0.487541740357844 562 3091274 SGTC_1301 naphtanilide LB 4.81 µM -0.0312941286258405 0.494103385357574 no 1645 0.487517486397121 576 67238 An a1-adrenergic receptor antagonist or alpha blocker. SGTC_2790 5423970 71.43 µM -0.0313048136436174 0.494107963342684 no 1646 0.487513225779246 564 1376240 YKL165C | YIL048W MCD4 | NEO1 SGTC_3330 9141424 71.43 µM -0.0313375324403889 0.494121981683046 no 1647 0.487500179268837 561 27261020 SGTC_946 3434-1334 87.4 µM -0.031505923071477 0.494194128618676 no 1648 0.487433034281696 564 4047976 SGTC_1144 3486-0183 12.5 µM -0.0315407536566131 0.4942090518004 no 1649 0.487419145790991 582 6744069 SGTC_2183 6420625 130.508 µM -0.0321734003928545 0.494480111002471 no 1650 0.487166884302766 564 2897619 SGTC_2295 7971645 200 µM -0.0323759500231442 0.494566894482974 no 1651 0.487086120766315 569 2978226 YKL099C UTP11 SGTC_888 0916-0002 6.97 µM -0.0341033210963128 0.495307005955184 no 1652 0.4863973800876 572 2802138 YIL048W NEO1 SGTC_3003 9075612 71.4286 µM -0.0343606725605734 0.495417272515252 no 1653 0.486294771845171 569 6501993 SGTC_2010 4012422 159 µM -0.0344372839483 0.495450098019913 no 1654 0.486264226400856 574 952393 SGTC_1008 4106-0037 6 µM -0.0347957723312444 0.495603699116529 no 1655 0.486121295891394 568 2905394 SGTC_2777 climbazole 1.536 µM -0.0351616162828848 0.495760452516833 no 1656 0.485975434530515 563 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2 SGTC_562 3772-2733 112 µM -0.0355474785739536 0.49592578389711 no 1657 0.485821593925272 566 2876874 YIL048W NEO1 SGTC_1703 st026983 48.3 µM -0.0358189825375956 0.496042116300115 no 1658 0.485713348451252 570 1104023 SGTC_1933 st074711 15.9 µM -0.0360745336564352 0.496151613630755 no 1659 0.485611464152577 562 17250958 SGTC_1505 k297-0037 20.6 µM -0.0367631005844601 0.496446648940223 no 1660 0.485336947807564 565 4089396 SGTC_924 2046-0044 21.3 µM -0.0373194349887679 0.496685027039852 no 1661 0.485115154702932 561 3623589 SGTC_517 1365-0151 113 µM -0.0373661047546184 0.496705024150585 no 1662 0.485096549137211 579 768657 SGTC_842 0271-0008 11.1 µM -0.0374919872109224 0.496758962440017 no 1663 0.485046364468069 564 1221709 SGTC_2303 7774051 200 µM -0.0377446331848702 0.496867216715049 no 1664 0.484945644598795 565 2953184 SGTC_1944 st076371 56.9 µM -0.0383095317427511 0.497109266452617 no 1665 0.484720445567332 564 24208455 SGTC_1215 3852-0577 11.2 µM -0.0388602862926633 0.497345256740747 no 1666 0.48450088979166 569 2884876 SGTC_1173 0443-0020 122 µM -0.0389947450542674 0.49740287050234 no 1667 0.484447289134033 568 5331295 SGTC_2519 cryptotanshinone 88.04 µM -0.0392119454464889 0.497495938047966 no 1668 0.484360704936457 568 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE) SGTC_2882 9058044 58.44 µM -0.0397813125568978 0.497739905089924 no 1669 0.484133737427975 578 18076804 SGTC_2259 7964009 200 µM -0.0398519272990712 0.497770162728719 no 1670 0.484105588543657 581 313134 SGTC_1777 st045864 34.765 µM -0.0402382772766359 0.497935709658729 no 1671 0.483951580737296 567 4691462 SGTC_1430 4049-0248 69.1 µM -0.0418648925835471 0.498632700892179 no 1672 0.483303201753789 571 22774488 SGTC_1867 st057372 64 µM -0.0419440688495494 0.498666627392403 no 1673 0.48327164271446 578 688837 SGTC_738 1315-0003 72.4 µM -0.0420400164577846 0.498707740313458 no 1674 0.483233398889988 576 6251474 SGTC_1866 st057638 64 µM -0.0449815339052481 0.499968165819181 no 1675 0.482061013931651 572 688802 SGTC_3270 9137563 49.47 µM -0.0450002740093882 0.4999761958744 no 1676 0.482053545274556 562 17015724 SGTC_1265 0819-1001 68.8 µM -0.0451113795447156 0.4999761958744 no 1677 0.482009265546301 577 3106768 SGTC_2591 skatole 100 µM -0.0456357379024068 0.499751510555442 no 1678 0.481800292053598 575 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite. SGTC_34 0469-0683 81.75 µM -0.0463927016651896 0.499427154970483 no 1679 0.481498626739447 567 3690923 SGTC_1947 st076332 61.6 µM -0.0477485458299208 0.498846182901171 no 1680 0.480958322110764 560 24208416 SGTC_3101 9120531 49.47 µM -0.0481826059709425 0.498660190879512 no 1681 0.480785356255083 573 24824904 SGTC_1520 flindersine 88 µM -0.0486722459532008 0.498450383599461 no 1682 0.480590247086654 581 68230 Flindersine is a natural alkaloid of the quinoline subtype. SGTC_308 4092-1169 104 µM -0.0490710956141047 0.498279479646073 no 1683 0.480431319002934 572 2268590 YDL196W YDL196W SGTC_1216 1165-0504 9.65 µM -0.0492392328656269 0.498207434244506 no 1684 0.480364322932346 577 6304004 SGTC_2161 5662504 8.5105 µM -0.0500629190698227 0.497854492505767 no 1685 0.480036124480627 566 2859334 SGTC_3327 9140648 26.9345 µM -0.0511717357197419 0.497379377773213 no 1686 0.479594336977965 578 8029710 SGTC_2627 acetyl isogambogic acid 100 µM -0.051249762754474 0.497345944249967 no 1687 0.479563249485651 588 6857789 A caspase activator and apoptosis inducer. SGTC_1325 1431-0015 227 µM -0.051947402365928 0.49704701602012 no 1688 0.479285301806033 576 1103340 SGTC_1734 st037168 69.4 µM -0.0549700134551862 0.495751893290941 no 1689 0.478081176727384 595 708907 SGTC_287 k060-0039 29.6 µM -0.0550605048529024 0.49571312032884 no 1690 0.478045130474345 572 5861974 SGTC_2690 usnic acid 100 µM -0.0557601466215676 0.495413345341814 no 1691 0.47776644195519 579 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_3078 9116413 49.47 µM -0.0558103890869064 0.495391818087806 no 1692 0.477746429275427 571 17177322 SGTC_680 0417-1641 114 µM -0.0561667062918591 0.495239148201935 no 1693 0.477604501903415 570 2835990 SGTC_1837 st055472 66.5 µM -0.0575621073056254 0.494641272925896 no 1694 0.477048716795182 590 676091 SGTC_1018 4259-0013 28.1 µM -0.0579635724098497 0.494469262852264 no 1695 0.47688882236224 592 6801262 SGTC_2263 7948595 193.29 µM -0.058420126688407 0.494273650750883 no 1696 0.476706991685404 603 2971371 SGTC_2397 5161689 200 µM -0.0588382373122999 0.494094511159698 no 1697 0.476540476115661 593 2259942 SGTC_1361 1608-0041 5.61 µM -0.0591889251636256 0.493944259787473 no 1698 0.476400815308673 568 X1361 SGTC_3063 1327-0034 4 µM -0.0601662502007852 0.493525531810128 no 1699 0.476011612718417 574 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_3276 9139060 49.47 µM -0.0610618264475704 0.493141834774291 no 1700 0.475654985237941 607 4870619 SGTC_2877 9040724 71.43 µM -0.0611000315696546 0.493125466466147 no 1701 0.475639772005273 591 6463895 SGTC_1495 4469-0029 237 µM -0.0613831922691198 0.493004151640402 no 1702 0.475527018871154 584 793680 SGTC_2083 5306046 65.942 µM -0.0616661938815126 0.49288290561899 no 1703 0.475414331042815 575 539837 SGTC_3161 9100388 49.47 µM -0.0625093417863599 0.492521680774254 no 1704 0.475078611410153 576 25236368 SGTC_2420 aureobasidin a 50 nM -0.0625785424574038 0.492492033810414 no 1705 0.475051058279789 603 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1 SGTC_2499 avocadenofuran 51.48 µM -0.0626811746274166 0.492448064194235 no 1706 0.47501019419118 612 6857792 A insecticide and lysyl oxidase inhibitor. SGTC_1206 3978-0017 132 µM -0.0631794350618404 0.492234601054799 no 1707 0.474811810250806 606 3873677 SGTC_229 benomyl 22.8748 µM -0.0634510559024645 0.492118235056898 no 1708 0.474703666196005 580 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C SGTC_3138 9097216 49.47 µM -0.0641681913982987 0.491811007876424 no 1709 0.474418152382858 572 25237486 SGTC_2381 9035592 200 µM -0.0647757862339264 0.491550712676525 no 1710 0.474176260368753 601 4749657 SGTC_642 0335-0876 158 µM -0.065008867435267 0.491450861035515 no 1711 0.474083469999578 575 6812350 SGTC_2058 5236698 133 µM -0.0666592601548517 0.490743850931187 no 1712 0.473426483912209 583 766665 SGTC_3026 9090633 49.47 µM -0.0667660340498941 0.490698111145636 no 1713 0.473383981975442 588 25236842 SGTC_861 0443-0273 110 µM -0.0672487346233522 0.490491333479774 no 1714 0.473191844142758 590 6149169 SGTC_534 k292-0788 63.4 µM -0.0673994412679607 0.490426774789577 no 1715 0.473131856991371 604 4146317 SGTC_3238 9133470 49.47 µM -0.067411891993284 0.490421441243507 no 1716 0.473126901141926 594 3534688 SGTC_1506 4226-2149 212 µM -0.0676425562214764 0.490322631384133 no 1717 0.473035088996034 603 991114 SGTC_1515 3460-0031 42.1 µM -0.0676504730949072 0.490319240035882 no 1718 0.473031937838677 578 2876596 SGTC_2940 9060638 45.86 µM -0.0683044829296751 0.490039084515919 no 1719 0.472771627801963 587 4027022 SGTC_669 0108-0021 26.2 µM -0.0705790941875025 0.489064757743176 no 1720 0.471866374666428 621 17201 SGTC_3131 9127911 49.47 µM -0.0726536163948728 0.488176195602426 no 1721 0.471040879851785 609 45595681 SGTC_1743 st037606 46.3785 µM -0.0732597494533648 0.487916586758158 no 1722 0.470799710439225 585 590142 YLR208W | YDL195W SEC13 | SEC31 SGTC_1663 st014140 55.4 µM -0.0734872285379837 0.487819158010268 no 1723 0.470709203372897 598 4207120 SGTC_1581 himbacine 57.9 µM -0.0736323390313228 0.487757007912424 no 1724 0.470651469074669 609 5281825 An alkaloid muscarinic receptor antagonist. SGTC_394 menadione 8.33 µM -0.0743262689548225 0.487459805336917 no 1725 0.470375387616972 576 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_3112 9123419 49.47 µM -0.074406456947761 0.487425462144745 no 1726 0.470343485573123 579 17015854 SGTC_766 1391-0721 126 µM -0.0746089652932246 0.487338731582756 no 1727 0.470262920367567 622 1020919 YIL115C NUP159 SGTC_932 2857-0803 154 µM -0.0751374477311379 0.487112395203993 no 1728 0.47005267652096 623 674898 SGTC_3175 9106517 49.47 µM -0.0752132109280385 0.487079947978673 no 1729 0.470022536664004 586 41468073 SGTC_2348 9022543 33.42 µM -0.0760358870528552 0.486727624712875 no 1730 0.469695273543963 595 3162678 YDL140C RPO21 SGTC_499 genistein 192 µM -0.0765134862409501 0.486523090503997 no 1731 0.469505292479677 584 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger. SGTC_2728 chlorpromazine 9.18 µM -0.0771352573494663 0.486256819278738 no 1732 0.469257972616614 587 2726 A thorazine and dopamine antagonist. SGTC_2869 9037858 32.47 µM -0.0781467776091273 0.485823652535785 no 1733 0.46885564889333 575 27187042 SGTC_2788 5282734 71.43 µM -0.0786061553363632 0.485626937149834 no 1734 0.468672945720496 592 743706 SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM -0.0793066050434875 0.485326996325189 no 1735 0.468394376393318 592 6728940 SGTC_315 k915-0449 187 µM -0.0796574435342999 0.485176766255848 no 1736 0.46825485349366 596 20970215 YNL149C PGA2 SGTC_731 3966-0296 387 µM -0.0821274977614184 0.484119142564799 no 1737 0.467272663464497 595 660956 SGTC_1821 st053465 65.6 µM -0.0831300674905228 0.483689895389393 no 1738 0.466874059091217 597 675086 SGTC_2316 5844804 197.44 µM -0.0832318512929802 0.483646318013037 no 1739 0.466833593463703 612 776813 SGTC_2113 5491891 107.031 µM -0.0834731278438819 0.48354301945978 no 1740 0.466737671840279 603 789979 SGTC_1567 st069303 68.4 µM -0.0848060676013542 0.482972363507808 no 1741 0.466207784836552 586 5581319 SGTC_2447 5741742 33.78 µM -0.0849342258236448 0.48291749844236 no 1742 0.466156840906998 586 1776504 SGTC_150 3970-0969 77.2 µM -0.0872373085778702 0.481931595322576 no 1743 0.465241442214232 584 6615640 SGTC_533 1222-0222 6.71 µM -0.0874971667367797 0.481820362128199 no 1744 0.465138168706224 609 3982874 SGTC_3110 9122132 49.47 µM -0.0882790964623147 0.481485662943894 no 1745 0.464827426344132 584 918317 SGTC_1614 st002383 48.6 µM -0.0884839817374951 0.481397965478785 no 1746 0.464746007560295 587 1947235 SGTC_2218 6965428 192.983 µM -0.0885612919240362 0.481364874474563 no 1747 0.46471528586586 582 675684 SGTC_502 l-744,832 89.3 µM -0.0886515631880227 0.481326235915433 no 1748 0.464679413935754 608 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.  SGTC_2275 7947463 200 µM -0.0896196452445113 0.480911881535702 no 1749 0.464294736288824 584 1225414 SGTC_2391 6285546 200 µM -0.090791749510692 0.480410230075228 no 1750 0.46382903295598 576 846083 SGTC_733 4069-0007 56.1 µM -0.0915801673569054 0.48007281080575 no 1751 0.463515804688875 569 5717425 YNL287W SEC21 SGTC_1991 st073000 8.92 µM -0.0920130033466725 0.479887575996708 no 1752 0.463343854122236 617 4301969 YIL048W NEO1 SGTC_2396 5342950 42.78 µM -0.0923917581980479 0.479725489103388 no 1753 0.463193393713153 581 1886677 SGTC_1768 st044301 37.178 µM -0.0927915169378667 0.479554417302102 no 1754 0.463034595218507 584 3931349 SGTC_3067 9117431 49.47 µM -0.0928502007160617 0.479529304622333 no 1755 0.463011284414408 597 17150885 SGTC_2810 7959871 45.46 µM -0.094138312081543 0.478978100901543 no 1756 0.46249964342983 599 2974535 SGTC_481 bay k-8644 50 µM -0.0945705303996924 0.478793156636999 no 1757 0.462327979115778 633 2303 A calcium channel antagonist. SGTC_1910 st062352 60.4 µM -0.0948359863164618 0.478679571511007 no 1758 0.46222255136425 587 2245730 SGTC_2057 5236571 38.335 µM -0.0963965676236603 0.478011854430294 no 1759 0.461602809034989 593 54684039 YBR257W POP4 SGTC_1344 1488-0097 29.1 µM -0.0965322760562579 0.477953792522084 no 1760 0.461548920514349 578 747966 SGTC_2834 9001755 58.44 µM -0.0965970916266922 0.477926061796497 no 1761 0.461523183120281 634 2989575 SGTC_2767 sibutramine 71.45 µM -0.0977286277232861 0.477441962172821 no 1762 0.461073891363364 617 64765 A serotonin-norepinephrine reuptake inhibitor.  SGTC_2462 5162487 171.77 µM -0.098169466448217 0.47725336924065 no 1763 0.460898863784272 589 2259986 SGTC_1313 1220-0047 237 µM -0.0985101876801869 0.477107610542731 no 1764 0.460763591354597 587 3528706 SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM -0.0986447084136387 0.477050064143612 no 1765 0.46071018546411 666 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W SGTC_2085 5307070 144.047 µM -0.0989340996381708 0.476926267580426 no 1766 0.460595297057386 615 2840351 SGTC_890 0929-0006 47.2 µM -0.0996286913780616 0.476629142350546 no 1767 0.460319557359391 600 1378169 SGTC_1765 st044815 90.4 µM -0.100413948592151 0.476293248843442 no 1768 0.460007848180397 585 645695 SGTC_3084 9116877 49.47 µM -0.100476580095925 0.47626645896112 no 1769 0.45998298755487 596 27241325 SGTC_1031 k035-0009 16 µM -0.101893137801197 0.475660572100989 no 1770 0.459420748427708 631 5180959 SGTC_2273 7815444 169.05 µM -0.103659837083194 0.474905002496707 no 1771 0.458719650126521 596 2824616 SGTC_920 mycophenolic acid 780.421 nM -0.103844471665203 0.474826044430464 no 1772 0.458646386969488 591 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_1590 st077108 57.8 µM -0.104204549016981 0.474672061978189 no 1773 0.458503512017439 592 5489485 SGTC_2162 5663267 200 µM -0.104249824650059 0.474652700702816 no 1774 0.458485547495669 636 6456493 SGTC_1601 4'-hydroxyflavanone 55.5 µM -0.105006064386502 0.474329317847919 no 1775 0.458185498320802 619 165506 SGTC_3189 9110682 49.47 µM -0.105094856096181 0.474291349887178 no 1776 0.458150270471151 604 17122418 SGTC_674 0498-0004 451 µM -0.105110069385303 0.474284844600969 no 1777 0.458144234676419 593 4231473 SGTC_107 0358-0022 2.6945 µM -0.105620181870325 0.474066721673404 no 1778 0.457941855750408 630 521106 YGL093W | YPR107C SPC105 | YTH1 SGTC_1401 3807-4679 7.6 µM -0.107782795695189 0.473142080090127 no 1779 0.457083995212124 585 3291456 SGTC_3012 9080433 71.4286 µM -0.108217498528072 0.47295623697488 no 1780 0.456911582326511 588 17688859 SGTC_2287 7945887 168.79 µM -0.109385915312723 0.472456747513324 no 1781 0.456448202331621 609 1245853 SGTC_2075 5212009 200 µM -0.109777706148358 0.472289269510418 no 1782 0.456292836041879 586 780898 SGTC_399 oxolinic acid 75 µM -0.110075224412912 0.47216209327603 no 1783 0.45617485839588 599 4628 A DNA gyrase inhibitor. SGTC_1565 sinapyl alcohol 95.1 µM -0.112401265383056 0.471167909863374 no 1784 0.455252626028189 593 5280507 A phenol propionate derived from cinnamic acid. SGTC_2336 9001819 198.65 µM -0.112685097403429 0.471046608144369 no 1785 0.455140108269381 592 2989602 SGTC_3085 9117376 49.47 µM -0.113304191286275 0.470782034391804 no 1786 0.454894697237499 589 16480349 SGTC_210 3551-0445 56.827 µM -0.11364731566319 0.470635403529499 no 1787 0.454758688914146 628 2865180 YOR207C RET1 SGTC_586 0957-0265 8.15 µM -0.116966499039464 0.469217191306416 no 1788 0.453443300552488 606 6752309 YPR165W | YPR107C RHO1 | YTH1 SGTC_743 1275-0778 158 µM -0.11702678328616 0.469191436763004 no 1789 0.453419414655982 619 2849257 YMR203W TOM40 SGTC_2171 5739187 198.077 µM -0.117780751154585 0.468869338689749 no 1790 0.453120690864113 593 2262761 SGTC_1034 k072-0165 12.7 µM -0.11882378482299 0.468423784189648 no 1791 0.452707482308149 639 5835461 SGTC_1307 1187-1599 12.2 µM -0.118900641735303 0.468390954646823 no 1792 0.45267703666916 606 1538471 SGTC_1970 st070122 35.8 µM -0.120498434025051 0.467708504342931 no 1793 0.452044160037311 629 102928 SGTC_3255 9139072 49.47 µM -0.12063352549027 0.467650808292632 no 1794 0.451990656623711 601 17646060 SGTC_1982 st072467 71.9 µM -0.121425721873575 0.467312483815201 no 1795 0.451676922252629 620 3163533 SGTC_3048 9093155 49.47 µM -0.12197001009745 0.467080047511183 no 1796 0.451461384689937 586 25236002 SGTC_1835 st008666 49.2 µM -0.122558043372295 0.466828942659767 no 1797 0.45122854021465 607 690455 SGTC_2211 7117706 200 µM -0.123098946745979 0.466597975104453 no 1798 0.451014372656382 585 822771 SGTC_1254 0550-0035 264 µM -0.123187036231742 0.466560361661488 no 1799 0.450979495483266 624 15121435 SGTC_259 usnic acid 108.925 µM -0.123708351264606 0.466337770809005 no 1800 0.450773099552585 652 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_2131 toluylene red 5.2905 µM -0.123818247289336 0.466290848796406 no 1801 0.450729591872412 597 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain. SGTC_3260 9137109 49.47 µM -0.123891651077374 0.466259508037743 no 1802 0.450700531746679 596 17478346 SGTC_3190 9110366 49.47 µM -0.124171732317678 0.466139925417151 no 1803 0.450589651668742 621 17123768 SGTC_2366 9070441 60.58 µM -0.124933231982384 0.465814813359571 no 1804 0.450288204577812 616 6837235 SGTC_120 rhodamine 6G 52.259 µM -0.125111436208442 0.465738734743958 no 1805 0.450217664826206 600 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase SGTC_1591 genipin 88.4 µM -0.127533640374735 0.464704777186422 no 1806 0.449259024693769 605 442424 A DNA cross-linking agent. SGTC_1880 MG-132 525 µM -0.127754567978001 0.464610482369893 no 1807 0.449171602427156 602 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1 SGTC_2080 5212524 12.4 µM -0.128653978617369 0.46422662261117 no 1808 0.448815726208683 603 260183 SGTC_1846 st056244 14.8 µM -0.128892153176768 0.464124977574967 no 1809 0.448721492867352 624 5393182 SGTC_1036 k216-0215 33.5 µM -0.129050599047739 0.464057359406456 no 1810 0.448658805641983 603 622330 SGTC_3252 9135871 49.47 µM -0.129121304489079 0.464027185572602 no 1811 0.448630832288133 630 17682838 SGTC_2446 5162541 200 µM -0.129700188254964 0.463780152374833 no 1812 0.448401816810296 602 1549321 SGTC_1662 st014054 52 µM -0.132489426264456 0.462590068733975 no 1813 0.447298592958725 595 2838777 SGTC_180 1486-1293 102.781 µM -0.132865494252215 0.462429637256423 no 1814 0.447149878251737 626 4140536 SGTC_2115 tiliquinol 12.7705 µM -0.133424186581501 0.462191309102377 no 1815 0.446928959143916 624 71208 A bioactive hydroxyquinoline. SGTC_1680 diphenhydramine 100 µM -0.133443826121369 0.462182931472442 no 1816 0.446921193541581 599 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1 SGTC_1366 1683-0113 21.9 µM -0.134605343606161 0.461687493431321 no 1817 0.446461958238012 616 708623 SGTC_2352 9027995 87.8 µM -0.134817629213235 0.461596950731954 no 1818 0.446378033498096 618 2997347 SGTC_2968 9090663 33.37 µM -0.135607537988056 0.461260061412679 no 1819 0.446065773026689 663 25236811 SGTC_1182 1222-0449 220 µM -0.135800174136674 0.461177907954107 no 1820 0.445989626698025 599 658318 SGTC_1785 bathophenanthroline 24 µM -0.13686471443241 0.460723943864314 no 1821 0.445568865060987 605 72812 An iron chelator. SGTC_446 go6976 132 µM -0.137021842469351 0.460656942279651 no 1822 0.445506765077071 606 3501 A protein kinase C inhibitor. SGTC_2228 7354201 200 µM -0.137299882447353 0.460538384896419 no 1823 0.445396881675087 613 753451 SGTC_1834 st055981 52.8 µM -0.138042932739825 0.460221562456675 no 1824 0.445103243454668 623 471719 YDL150W RPC53 SGTC_288 1315-0019 35.1 µM -0.138375165578839 0.460079912883337 no 1825 0.444971961591752 611 6811474 SGTC_3262 9137218 49.47 µM -0.138547075859826 0.460006619835036 no 1826 0.444904033583432 598 17650664 SGTC_2484 5809818 12.04 µM -0.138695477501607 0.459943350664801 no 1827 0.444845395995069 618 2870548 SGTC_2108 5365811 200 µM -0.138696507676737 0.459942911466157 no 1828 0.444844988948632 595 780283 SGTC_2572 astragaloside iv 100 µM -0.140432856552969 0.459202716864557 no 1829 0.444158999645862 609 45006101 An anti-inflammatory agent. SGTC_2935 9038016 29.96 µM -0.141620048187241 0.458696705778018 no 1830 0.44369006519039 611 6463195 SGTC_1764 st044502 93.5 µM -0.141751741701282 0.458640578781544 no 1831 0.44363805179031 610 8407 SGTC_1235 benzylparaben 21.5 µM -0.142799051095085 0.458194251158818 no 1832 0.443224443258938 641 7180 SGTC_910 3454-3003 490 µM -0.14331347278469 0.457975041408528 no 1833 0.443021307961709 625 820824 SGTC_1831 st055328 12 µM -0.143480956499794 0.457903674576891 no 1834 0.442955175071324 606 1103068 SGTC_2361 9034121 116 µM -0.143543458054093 0.457877042258167 no 1835 0.442930496013687 624 6496917 SGTC_883 0850-0245 24.6 µM -0.144126338817321 0.457628682096656 no 1836 0.442700353243429 603 6823229 YPR165W RHO1 SGTC_314 1671-0008 2.74 µM -0.144906357881774 0.457296349009985 no 1837 0.442392403279348 624 3913060 SGTC_1569 carminic acid 40.6 µM -0.145232493477879 0.457157405284577 no 1838 0.442263655907413 594 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_2731 amoxapine 43.43 µM -0.145760767101134 0.456932355704249 no 1839 0.442055124180724 594 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine. SGTC_1568 digitonin 820 nM -0.147580342602193 0.456157305423253 no 1840 0.441336984768481 646 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1 SGTC_84 0443-0269 128.823 µM -0.148195362356671 0.455895374618099 no 1841 0.441094295855107 609 6150058 SGTC_489 paxilline 115 µM -0.148908042123178 0.455591875365428 no 1842 0.440813097636156 660 105008 A toxic potassium channel blocker. SGTC_871 0574-0004 149 µM -0.149233428831919 0.455453315952993 no 1843 0.440684721467915 611 9551173 SGTC_593 1203-0218 61.7 µM -0.149800889023317 0.455211687371156 no 1844 0.440460853967049 624 3666956 SGTC_2125 5246583 200 µM -0.150662510946987 0.454844834340015 no 1845 0.440120973759245 619 835267 SGTC_2974 9094440 9.66 µM -0.151155912336988 0.454634775998122 no 1846 0.439926363734493 617 25236134 SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM -0.151433990507651 0.454516393916957 no 1847 0.439816689041688 649 5393153 SGTC_466 geldanamycin 89.2 µM -0.152416271932749 0.45409825427465 no 1848 0.439429311934532 611 5288382 HSP90 inhibitor. SGTC_2285 7945142 200 µM -0.154341714466291 0.453278775816642 no 1849 0.43867015397882 631 2970608 SGTC_2229 7354935 190 µM -0.154687275469043 0.453131724190844 no 1850 0.438533930973385 611 318112 SGTC_1103 duloxetine 36.1 µM -0.154806326274968 0.453081064248255 no 1851 0.438487001846614 619 60835 A selective serotonin reuptake inhibitor. SGTC_1690 st023502 41.2 µM -0.15508487224818 0.452962536972859 no 1852 0.438377204044205 595 24207482 SGTC_2557 derrustone 83.84 µM -0.156428980732314 0.452390649123587 no 1853 0.437847447516951 672 629853 An antioxidant. SGTC_917 harmaline 728.087 nM -0.156606427550359 0.452315156858034 no 1854 0.437777518301889 614 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7 SGTC_3340 9146634 11.102 µM -0.156664707110791 0.452290363010548 no 1855 0.437754551596964 613 4907387 SGTC_2457 5731572 11.68 µM -0.159230676991807 0.451198909372827 no 1856 0.436743567721321 648 2865357 SGTC_1750 st081859 2.357 µM -0.160538945698411 0.450642569373419 no 1857 0.43622827261169 639 5291695 SGTC_789 1309-1135 70.6 µM -0.160591528513342 0.450620210601953 no 1858 0.436207563780786 599 3092424 SGTC_1713 st033146 12.748 µM -0.160928818097088 0.450476795217503 no 1859 0.436074732281035 660 674619 SGTC_959 1222-0044 107 µM -0.162019102063787 0.45001325127592 no 1860 0.435645405670207 634 6083612 SGTC_2341 7987486 176.74 µM -0.165005728122307 0.448743811696696 no 1861 0.43446973673534 614 1258686 SGTC_3342 9147791 14.508 µM -0.166610506004201 0.448061930560228 no 1862 0.433838263327591 622 1838168 SGTC_2823 7987624 58.44 µM -0.166651709487042 0.448044424929364 no 1863 0.433822052144936 644 2239440 SGTC_1449 4112-4002 201 µM -0.166728862507739 0.44801164612053 no 1864 0.433791697201887 616 2059539 SGTC_1242 0402-0103 60.1 µM -0.167690134172228 0.447603275353361 no 1865 0.433413529036147 618 432868 SGTC_1380 2291-0730 164 µM -0.167759606977894 0.44757376382143 no 1866 0.433386200510802 632 2999191 SGTC_2000 st075254 36.4 µM -0.167923507252669 0.447504141352168 no 1867 0.433321728303668 617 17234175 SGTC_2813 7971799 71.43 µM -0.168633788323453 0.447202442933116 no 1868 0.433042350958196 641 2234054 SGTC_2025 5147754 141 µM -0.169522886742731 0.446824833273924 no 1869 0.432692685931393 628 315777 YLR208W SEC13 SGTC_2291 7917025 104.35 µM -0.170315193445571 0.446488372706108 no 1870 0.432381131591402 626 2964612 SGTC_1510 1123-0200 71.5 µM -0.170784832816249 0.446288954054088 no 1871 0.432196477756766 674 5378812 YNL149C | YNL150W PGA2 | YNL150W SGTC_2534 helenine 20.12 µM -0.170982379316381 0.446205075754105 no 1872 0.43211881041461 600 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58 SGTC_895 0964-0006 13.7 µM -0.17129590021517 0.446071959634778 no 1873 0.43199555198797 644 6738897 SGTC_1068 loratadine 26.9 µM -0.171483188952165 0.445992442635797 no 1874 0.431921923961217 642 3957 A H1 histamine antagonist. SGTC_827 3253-0474 693 µM -0.171512653000726 0.445979933310684 no 1875 0.431910341099985 642 5402065 SGTC_3296 9122258 64.045 µM -0.171581367730481 0.445950759833852 no 1876 0.431883328299076 651 4730474 SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM -0.172179924462588 0.445696649405557 no 1877 0.431648040066295 679 6710655 SGTC_2705 st078069 42.8 µM -0.172212780637542 0.445682701336385 no 1878 0.431635125247752 655 1530061 SGTC_550 4123-0385 25.7 µM -0.173291132928679 0.445224957756025 no 1879 0.431211296575257 649 5731123 SGTC_1897 st060201 15 µM -0.173385118327014 0.445185065883871 no 1880 0.431174360901708 618 611878 SGTC_1437 4092-1038 11.6 µM -0.173489632860524 0.445140705597914 no 1881 0.431133288050729 628 3977136 SGTC_3144 9087057 49.47 µM -0.173997693124284 0.444925073628048 no 1882 0.430933637598994 706 17249618 SGTC_2526 patulin 37.61 µM -0.174349592973204 0.444775729127561 no 1883 0.430795363236171 627 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.  SGTC_2639 lactacystin 53 µM -0.17457094973376 0.444681790462673 no 1884 0.430708388388227 629 3870 A proteasome inhibitor. SGTC_1275 0867-0008 21.1 µM -0.174896257664223 0.444543742976541 no 1885 0.430580575452097 642 3422836 SGTC_2706 st078239 82.5 µM -0.175729290798214 0.444190268221722 no 1886 0.430253311325178 606 15434492 SGTC_381 3461-2219 42.7 µM -0.175956673635968 0.44409379225285 no 1887 0.43016399036343 660 2883159 SGTC_1447 4239-0816 81.9 µM -0.176843118610712 0.443717715348725 no 1888 0.429815809514104 637 1341554 SGTC_2876 9059903 25.97 µM -0.177147435610883 0.443588619629791 no 1889 0.429696291426476 610 6916095 SGTC_454 lyso-paf C-16 6.67 µM -0.177493505528168 0.443441818988906 no 1890 0.429560383042018 646 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_3236 9132701 49.47 µM -0.178045532914654 0.44320766858315 no 1891 0.429343608440342 654 24282524 SGTC_3299 9121982 43.1275 µM -0.17810988010189 0.443180376081288 no 1892 0.429318341448982 646 17594604 YPL160W CDC60 SGTC_123 0083-0120 66.675 µM -0.179347056176017 0.442655687292068 no 1893 0.428832600150613 629 16001701 SGTC_3339 9145883 14.936 µM -0.181768670230426 0.441628967925827 no 1894 0.427882136212879 634 2030670 SGTC_1514 1189-1591 158 µM -0.181919245313668 0.441565139765109 no 1895 0.427823050467218 678 767698 YMR146C TIF34 SGTC_922 1866-0035 480 µM -0.182102208401211 0.44148758450443 no 1896 0.42775125782906 652 3156169 SGTC_2992 9074591 71.4286 µM -0.182333306827506 0.441389628614969 no 1897 0.427660580849466 615 17741321 SGTC_387 norethindrone acetate 66.7 µM -0.183004016330819 0.441105354720922 no 1898 0.427397433631167 652 541197 SGTC_2839 9003951 25.97 µM -0.183454510626142 0.440914433989751 no 1899 0.427220704117721 625 2990634 SGTC_3087 9117406 49.47 µM -0.183844159404692 0.440749310830821 no 1900 0.427067856159971 616 42546093 SGTC_1573 oleylamine 1.06 µM -0.184218155398922 0.440590830608998 no 1901 0.426921158634881 650 5356789 An amine of the fatty acid oleic acid. SGTC_1199 1638-0010 4.46 µM -0.184538569132543 0.440455063354053 no 1902 0.426795486444803 628 3111136 SGTC_306 1672-3436 11.6 µM -0.185150618789043 0.440195742186441 no 1903 0.426555449917932 643 6797378 SGTC_2180 6301957 200 µM -0.185780571952005 0.439928862216308 no 1904 0.426308420314991 651 845462 SGTC_2802 7925815 54.55 µM -0.186544578821391 0.439605226960653 no 1905 0.426008861740843 632 1262923 SGTC_1122 capsaicin 818.572 nM -0.187209523726599 0.439323587445118 no 1906 0.425748178998652 644 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_435 c-PAF 6.7 µM -0.187432753786081 0.439229044526667 no 1907 0.425660671914064 633 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase SGTC_2597 laccaic acid a 100 µM -0.188475364955954 0.438787521388415 no 1908 0.425252012678192 652 5491415 A textile dye. SGTC_1884 5633444 25 µM -0.18880383841459 0.438648435778722 no 1909 0.425123281665835 633 5724239 SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM -0.190286830332549 0.438020586652629 no 1910 0.42454218649196 626 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1 SGTC_820 1582-0060 59.9 µM -0.190624780637444 0.437877531575441 no 1911 0.424409787025595 640 3848840 SGTC_1092 toremifene 6.32 µM -0.19152930171718 0.437494685888573 no 1912 0.424055462998205 672 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM -0.192161423399669 0.437227170109192 no 1913 0.42380788119624 624 279621 SGTC_2888 9058547 12.99 µM -0.192771857434201 0.436968859842293 no 1914 0.423568822291676 639 16476514 SGTC_2061 5245884 80.95 µM -0.193094557966549 0.436832317262971 no 1915 0.423442457284677 650 573863 SGTC_2327 6189656 200 µM -0.193337469314481 0.436729540424915 no 1916 0.423347341797868 669 5349088 SGTC_774 k060-0086 136 µM -0.193351710554328 0.436723515027429 no 1917 0.42334176557093 684 5911235 SGTC_2871 9038510 12.99 µM -0.193914044647598 0.436485606028253 no 1918 0.42312159319781 643 4945164 SGTC_1686 st019653 115.5 µM -0.19419968059832 0.436364769644127 no 1919 0.423009766477743 665 97252 SGTC_783 0848-0141 92.7 µM -0.195214405823696 0.435935545002098 no 1920 0.422612550900079 628 6755076 YHR007C | YLR033W ERG11 | RSC58 SGTC_396 dithiazanine 1.25 µM -0.196471988595516 0.435403697348428 no 1921 0.422120377621457 622 10578 An antihelmenthic. SGTC_51 1013-0126 23.419 µM -0.197081194944168 0.435146098225851 no 1922 0.421881999542411 634 1627850 SGTC_68 0986-0284 82.829 µM -0.197118420055877 0.435130358709594 no 1923 0.421867434549857 605 423278 YIL048W NEO1 SGTC_3009 9080819 71.4286 µM -0.198066524718721 0.43472951594916 no 1924 0.421496507675791 648 17027216 SGTC_2383 9036125 200 µM -0.198089879060032 0.434719642969954 no 1925 0.421487371637264 641 79580 SGTC_2513 baicalein 25.65 µM -0.198681861993547 0.434469397533197 no 1926 0.42125580659784 665 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2 SGTC_2154 5570129 200 µM -0.199567912508918 0.434094891736126 no 1927 0.420909262513146 644 673366 SGTC_2109 5483026 200 µM -0.201380761051786 0.433328842100718 no 1928 0.420200428756469 639 759335 SGTC_2816 7982706 58.44 µM -0.201719923106384 0.433185551193071 no 1929 0.420067843189914 644 2981853 SGTC_2674 ligustilide 100 µM -0.201939674328016 0.433092714268606 no 1930 0.419981942666112 622 5319022 A signalling regulator. SGTC_1381 2324-0066 62.1 µM -0.202189853919752 0.432987026955745 no 1931 0.419884152364486 668 10885928 SGTC_2822 7994718 71.43 µM -0.202369582985492 0.432911104128366 no 1932 0.419813902846282 627 1018011 SGTC_940 3232-1287 54.8 µM -0.202568404141618 0.432827119127284 no 1933 0.419736193904917 665 1585493 YIL048W NEO1 SGTC_878 0828-0289 13.7 µM -0.202648329499952 0.432793358326976 no 1934 0.419704956083995 621 745350 YLR208W SEC13 SGTC_1029 k015-0030 64.7 µM -0.202737383897383 0.432755741960815 no 1935 0.419670150888917 647 2208316 SGTC_768 0384-0033 77.3 µM -0.203022210966413 0.432635435775612 no 1936 0.419558835938103 637 3965305 YMR134W ERG29 SGTC_3275 9138069 49.47 µM -0.203262152731371 0.432534093236833 no 1937 0.419465067873127 624 17617007 SGTC_2455 5377712 9.75 µM -0.204007863991286 0.432219160703767 no 1938 0.419173676784954 618 2243908 SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM -0.20430199366705 0.432094954209801 no 1939 0.419058756054535 623 5355888 SGTC_591 4299-0174 154 µM -0.206092846850828 0.431338849388617 no 1940 0.418359193111879 651 5509088 SGTC_277 nystatin 15.5 µM -0.20873506852937 0.430223753728841 no 1941 0.417327531186545 665 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_1548 st061468 90.8 µM -0.208836389263275 0.430181004401677 no 1942 0.417287981538522 636 390799 SGTC_1635 st007035 42.4 µM -0.209053636368906 0.430089346083884 no 1943 0.417203183882851 639 3716403 SGTC_654 1124-0271 80.9 µM -0.209102566360989 0.430068702642567 no 1944 0.417184085661954 642 5403748 SGTC_1490 4089-0339 670 nM -0.209573288654888 0.429870115857323 no 1945 0.41700036461013 659 742542 SGTC_1716 st033144 30.6155 µM -0.210037401832157 0.429674334673625 no 1946 0.416819240813676 665 674617 SGTC_2753 fluvastatin 17.09 µM -0.211110410618224 0.429221763672836 no 1947 0.416400558401281 652 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5 SGTC_1255 0566-0045 221 µM -0.212727414660198 0.428539923590327 no 1948 0.415769791167882 650 2788469 SGTC_1292 0kpi-0043 232 µM -0.213230122815956 0.428327990625517 no 1949 0.415573736944035 667 3333905 SGTC_3281 9140613 49.47 µM -0.213525983526043 0.428203270583601 no 1950 0.415458362239021 634 16013766 SGTC_2984 9022109 38.96 µM -0.21416544570035 0.427933729908214 no 1951 0.415209020618504 652 6459207 SGTC_2612 dictamnine 15.46 µM -0.214570068565688 0.427763194069184 no 1952 0.415051266102405 656 68085 A quinoline derivative and established mutagen. YOR116C RPO31 SGTC_903 1134-0042 114 µM -0.215900785077662 0.427202434152985 no 1953 0.414532542564534 636 701009 SGTC_2135 5326629 150.42 µM -0.216248319748996 0.427056008265776 no 1954 0.414397095379018 643 5020077 SGTC_544 k015-0020 52.4 µM -0.216658992139155 0.426882993682143 no 1955 0.41423705419857 612 3008304 SGTC_2640 pentamidine 10.38 µM -0.217066127314652 0.426711483196775 no 1956 0.414078405544851 654 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_1240 0356-0016 42.1 µM -0.21802240815401 0.426308693185736 no 1957 0.41370582609204 641 4305613 SGTC_1787 fluconazole 80 µM -0.218714729787659 0.426017131976819 no 1958 0.413436137031438 649 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C SGTC_2582 agaric acid 100 µM -0.219879086942704 0.425526871129635 no 1959 0.412982661976917 651 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase. SGTC_2944 9067346 25.62 µM -0.221496335079179 0.424846108465415 no 1960 0.412352994961391 671 6473075 SGTC_2727 riluzole 51.77 µM -0.223223444103567 0.424119348540727 no 1961 0.411680803243773 640 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.  SGTC_2325 6158266 200 µM -0.223355732128891 0.424063692923117 no 1962 0.411629327335304 629 3623240 SGTC_3222 9128301 49.47 µM -0.223488063687417 0.424008020505588 no 1963 0.4115778360089 650 4911358 SGTC_2733 amorolfine 100 µM -0.224676215412115 0.423508228372426 no 1964 0.411115584463046 652 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_1180 1193-0155 285 µM -0.229672396935822 0.42140795658554 no 1965 0.409173172806219 671 2921347 SGTC_171 k064-0041 9.68 µM -0.23018541270095 0.421192422852348 no 1966 0.408973848260016 624 53325 SGTC_2288 7946289 167.31 µM -0.231195236493981 0.420768233804033 no 1967 0.408581565249106 684 1246052 SGTC_3122 9126309 49.47 µM -0.232726946211036 0.420124995795462 no 1968 0.40798672180429 658 17591206 SGTC_443 clozapine 122 µM -0.23386877190012 0.419645627359855 no 1969 0.407543428688599 650 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_1682 st012968 530 nM -0.234143510868572 0.419530302486552 no 1970 0.407436783911862 641 24207270 SGTC_2913 7966556 36.57 µM -0.235370166973428 0.419015483790373 no 1971 0.406960719505229 667 2976516 SGTC_3271 9137798 49.47 µM -0.236105565574758 0.418706908730245 no 1972 0.406675377653373 643 6498326 SGTC_1966 st070145 16.1 µM -0.236228759743184 0.418655221040142 no 1973 0.406627581951446 643 3748532 SGTC_2286 7945697 125 µM -0.236282772134007 0.418632559893052 no 1974 0.406606627176255 663 1245733 SGTC_2537 larixol 68.93 µM -0.236757498486299 0.418433397891973 no 1975 0.40642246272628 654 6708759 SGTC_2116 5511452 16.8835 µM -0.236769829192739 0.418428225067667 no 1976 0.406417679450792 676 870744 SGTC_3208 9114115 49.47 µM -0.237816237904752 0.417989300208837 no 1977 0.406011811956244 692 650895 SGTC_2485 5633444 17.78 µM -0.238300371392407 0.417786260903641 no 1978 0.405824066657752 635 5724239 SGTC_318 1488-0629 67.2 µM -0.238399986500842 0.417744486335782 no 1979 0.405785438947284 669 3662576 SGTC_3068 9116768 49.47 µM -0.238418437716334 0.417736748740372 no 1980 0.405778284227566 661 41904888 SGTC_2498 4'-Methoxychalcone 54.63 µM -0.240642996798652 0.416804104694664 no 1981 0.40491591130673 644 641818 YHR062C RPP1 SGTC_2870 9038528 12.99 µM -0.240751103336988 0.416758793026318 no 1982 0.404874014436065 672 6463316 SGTC_1697 st025554 27.742 µM -0.240852965972695 0.416716099433101 no 1983 0.404834538398127 635 1269519 SGTC_2231 micatex 6.853 µM -0.241839661160108 0.416302597698474 no 1984 0.404452202869051 658 20737 An antifungal of unknown mechanism. SGTC_1088 bifonazole 369 nM -0.241841958924933 0.416301634864893 no 1985 0.404451312612134 661 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase. SGTC_1109 tnp00067 928.257 nM -0.242320958444239 0.41610093042295 no 1986 0.404265737570872 644 676295 SGTC_2963 9082507 9 µM -0.242352323072136 0.416087789167899 no 1987 0.404253586969055 687 16459611 SGTC_1166 k206-0078 225 µM -0.242689063454131 0.415946706487484 no 1988 0.404123140157076 650 5404595 SGTC_213 1246-0773 967 nM -0.242897079601638 0.415859560261071 no 1989 0.404042563988042 668 6251622 SGTC_1114 scopoletin 1.73284 µM -0.246065922661403 0.414532520056411 no 1990 0.402815600967574 668 5280460 A coumarin with genotoxic properties. SGTC_3079 9117512 49.47 µM -0.246243902458255 0.414458014896259 no 1991 0.402746716178321 665 7185044 SGTC_2701 st077767 14.721 µM -0.246557188263954 0.414326875977366 no 1992 0.4026254702753 663 5721188 SGTC_3288 9119690 36.221 µM -0.246958471728989 0.414158915898425 no 1993 0.40247018175311 675 17595618 YKL019W RAM2 SGTC_2077 5212015 200 µM -0.247374800024046 0.413984675290265 no 1994 0.402309087453255 653 780900 SGTC_1523 st012844 44.7 µM -0.249113080394122 0.413257358122865 no 1995 0.401636655829096 678 4274103 SGTC_1323 1348-1351 11.2 µM -0.249171311883517 0.413232998513203 no 1996 0.40161413474789 644 6989654 SGTC_1587 estradiol valerate 56.1 µM -0.249355013663184 0.413156153902113 no 1997 0.401543090060182 684 13791 A steroid. SGTC_612 0302-0167 22.4 µM -0.250188311509533 0.412807617447685 no 1998 0.401220861974682 651 235821 SGTC_2293 7624732 200 µM -0.250894419480698 0.412512333408515 no 1999 0.40094786953021 653 894453 SGTC_949 1165-0505 146 µM -0.251577046763924 0.41222691571413 no 2000 0.400684001060804 649 6244267 SGTC_1188 1403-0014 4.57 µM -0.252291926566234 0.411928062470791 no 2001 0.400407714007354 658 9614867 SGTC_149 3970-0822 46.1 µM -0.252715675577805 0.41175093963366 no 2002 0.400243966819472 652 3114250 YBL034C STU1 SGTC_449 xestospongin c 11.1929 µM -0.253390415663696 0.411468942167158 no 2003 0.399983266620054 684 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1 SGTC_1915 st067105 30.6 µM -0.25401276049619 0.411208883044622 no 2004 0.399742849951743 676 69751 YOR207C | YOR116C RET1 | RPO31 SGTC_2618 avocadyne 43.43 µM -0.254443535613398 0.411028897965106 no 2005 0.399576460411375 648 3015189 SGTC_2682 pyrogallin 40.03 µM -0.256960700755251 0.409977559714109 no 2006 0.398604555436699 672 822798 An ATP competetive kinase inhibitor. SGTC_2016 5121758 140 µM -0.257281210096654 0.409843739621621 no 2007 0.398480848260305 688 2795203 SGTC_41 0478-0632 82.643 µM -0.258682878321903 0.409258634163385 no 2008 0.397939965569031 677 3750424 SGTC_1463 k081-0032 34.1 µM -0.258856763609298 0.409186062412555 no 2009 0.397872879502544 672 977755 SGTC_1623 st003709 20.3 µM -0.259330254401621 0.408988464836787 no 2010 0.397690219009351 631 16192618 SGTC_3184 9108758 49.47 µM -0.259689189739725 0.408838689047552 no 2011 0.397551765988365 657 902885 SGTC_2166 5933061 31.504 µM -0.260007526568684 0.408705865256592 no 2012 0.397428983928712 643 2877375 SGTC_3180 9109287 49.47 µM -0.261761953382054 0.407974031593028 no 2013 0.39675248666422 649 18891271 SGTC_2307 7538926 6.34 µM -0.263519390561806 0.407241263946428 no 2014 0.396075140024803 659 96582 SGTC_2264 7948757 110.76 µM -0.26390364819397 0.407081089950322 no 2015 0.395927082212219 644 2971411 SGTC_618 k072-0232 33.2 µM -0.264870904246464 0.406677967667816 no 2016 0.395554456536422 702 5872756 YGL099W LSG1 SGTC_3218 9131285 49.47 µM -0.265480643458735 0.406423898081101 no 2017 0.395319609662421 699 17156417 SGTC_695 3505-6186 243 µM -0.265794845934239 0.406292989787569 no 2018 0.395198606417616 678 1819379 SGTC_983 1491-0821 12.2 µM -0.266599076610075 0.405957965492672 no 2019 0.394888933334965 656 46495113 SGTC_350 k064-0020 19.8 µM -0.268014953264158 0.405368310795291 no 2020 0.394343904320456 672 2790705 SGTC_3021 9087658 49.47 µM -0.268795421669477 0.405043369348927 no 2021 0.394043558354519 654 25237042 SGTC_3007 9078383 71.4286 µM -0.269133338969741 0.40490270061933 no 2022 0.393913537905893 671 6496995 SGTC_1389 3405-0187 19 µM -0.270136161444764 0.404485316555881 no 2023 0.39352775154117 653 799890 SGTC_2622 2-methoxyxanthone 59.94 µM -0.270734415757259 0.404236369257068 no 2024 0.393297652514825 649 71034 A hepatoprotective. SGTC_1473 k844-0725 134 µM -0.272639825324268 0.403443743633258 no 2025 0.392565047539819 643 54682906 SGTC_2610 ononetin 44.17 µM -0.272707153850807 0.403415743074069 no 2026 0.392539167550193 683 259632 SGTC_1656 st012921 11 µM -0.274528038190349 0.402658662679936 no 2027 0.391839429810354 666 6732821 SGTC_2110 5483698 200 µM -0.276197084832515 0.401965033211205 no 2028 0.39119834807642 658 2848765 YHR062C RPP1 SGTC_85 0868-0259 160.055 µM -0.27656876160895 0.401810612147062 no 2029 0.391055626987669 685 83173 SGTC_1065 prochlorperazine maleate 2.48 µM -0.277609296811011 0.401378381147456 no 2030 0.390656147372828 673 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine. SGTC_1484 3473-2379 286 µM -0.278662089452999 0.400941181280316 no 2031 0.390252079339204 672 671917 SGTC_1865 st057639 52.2 µM -0.280988823628761 0.399975384346681 no 2032 0.389359486046474 658 688818 SGTC_1729 st035615 45.989 µM -0.281113296357818 0.399923734524274 no 2033 0.389311751600971 648 17385451 SGTC_1718 roemerine 11.9335 µM -0.281164322900917 0.399902561622093 no 2034 0.389292183751196 675 235224 An aporphine alkaloid with mutagenic activity. SGTC_202 3594-0513 34.79 µM -0.282374603982224 0.399400455213133 no 2035 0.388828143031863 670 708429 SGTC_1047 2043-3044 82 µM -0.283991319729681 0.39872999188809 no 2036 0.388208516377839 736 669592 SGTC_2095 5432005 200 µM -0.28422041498704 0.398635008603408 no 2037 0.388120735711002 687 783734 SGTC_403 arphamenine a 50 µM -0.284867464820152 0.398366773080289 no 2038 0.387872841487451 701 5487158 An arginine aminopeptidase inhibitor. SGTC_386 1509-0011 3.07 µM -0.285070174030462 0.398282749530473 no 2039 0.387795190028225 690 3107280 SGTC_1063 disulfiram 1.84 µM -0.285590487003298 0.398067099905851 no 2040 0.387595895203616 662 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_1751 st044839 27.194 µM -0.285938656653334 0.397922814420821 no 2041 0.387462552754031 654 5291326 SGTC_3249 9135183 49.47 µM -0.286266509724507 0.397786961119551 no 2042 0.387337003308044 707 4902779 SGTC_2382 9035899 200 µM -0.286471607781755 0.397701980422716 no 2043 0.387258468178162 704 6462679 SGTC_2246 7293507 91.5585 µM -0.287135711929512 0.397426847644097 no 2044 0.387004204389415 700 887656 SGTC_2380 9035439 200 µM -0.28813571297115 0.397012651901626 no 2045 0.386621428145981 668 6462575 SGTC_2732 terfenadine 20 µM -0.288177494122061 0.396995348869248 no 2046 0.386605437728182 675 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.  SGTC_1428 4049-0204 61.7 µM -0.289469545425398 0.396460365592553 no 2047 0.386111041003013 691 X1428 SGTC_2959 9079155 11 µM -0.29047600528258 0.396043768508942 no 2048 0.385726052418349 688 16189457 SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM -0.290534359928594 0.396019617803329 no 2049 0.38570373418876 706 689007 SGTC_2988 9073640 71.4286 µM -0.290539476725336 0.396017500180316 no 2050 0.385701777244466 701 9102229 SGTC_1364 1653-0028 37.6 µM -0.290614296771472 0.395986535718388 no 2051 0.385673162279012 658 5718652 SGTC_2765 myclobutanil 7.74 µM -0.291811221526765 0.395491274790888 no 2052 0.385215482476197 715 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11 SGTC_2652 actinonin 100 µM -0.293068382895102 0.394971270972275 no 2053 0.384734941518879 668 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase. SGTC_2015 5119600 184 µM -0.29427514772498 0.394472288745206 no 2054 0.384273830783037 709 2828786 SGTC_1156 4092-0367 4.88 µM -0.295027215006069 0.394161405793849 no 2055 0.383986544972598 666 1357585 SGTC_874 0599-0792 117 µM -0.297936902020096 0.392959261669955 no 2056 0.382875661233824 718 765305 SGTC_335 4077-0256 27.6 µM -0.298200037211809 0.392850596869158 no 2057 0.382775246696091 700 3121989 SGTC_2047 4141938 200 µM -0.298297847938183 0.392810206897063 no 2058 0.382737923332578 675 3807862 SGTC_1964 st076914 61 µM -0.299576800613734 0.392282182403512 no 2059 0.382249991141948 696 24208661 SGTC_856 0433-0016 11.3 µM -0.299629492064025 0.392260432618226 no 2060 0.382229892873734 679 3911780 SGTC_981 1488-1094 54.9 µM -0.299744449555269 0.392212982051189 no 2061 0.382186045371977 651 3449522 SGTC_2907 7721985 69.9 µM -0.299862329020443 0.392164327056406 no 2062 0.382141084929325 664 3267881 SGTC_588 3970-1144 52.9 µM -0.301384080146696 0.391536372731231 no 2063 0.381560816253225 668 1888707 SGTC_1576 erythromycin ethylsuccinate 23.2 µM -0.302322966304445 0.391149079887096 no 2064 0.381202936196645 667 3256 An antibiotic and ribosome inhibitor. SGTC_1472 k841-0093 193 µM -0.304070052192661 0.390428690164714 no 2065 0.380537261064552 698 X1472 SGTC_1702 st027038 51 µM -0.304444974772207 0.390274144296493 no 2066 0.380394453975151 690 5521182 SGTC_957 1187-1561 14.1 µM -0.305286724487882 0.389927232015176 no 2067 0.380073892981152 690 1538454 SGTC_1442 4112-3290 3 µM -0.307439473791508 0.389040413771378 no 2068 0.37925444315803 685 704353 SGTC_1848 st056003 16.4 µM -0.307699629975843 0.388933282295199 no 2069 0.379155450656093 652 146492 SGTC_1467 k284-1082 293 µM -0.30912719417745 0.388345566478675 no 2070 0.378612386812359 709 3334705 SGTC_3229 9132204 49.47 µM -0.309220842187216 0.388307021321997 no 2071 0.378576770264529 667 17682924 SGTC_22 0964-0034 14.468 µM -0.311368110745864 0.387423516434824 no 2072 0.377760396873207 694 138402 SGTC_1940 st075990 51.1 µM -0.312100688649251 0.387122226507434 no 2073 0.377482001595345 703 1084979 SGTC_45 0kpi-0036 14.9 µM -0.312309538142656 0.387036344678438 no 2074 0.377402645971844 698 2795021 SGTC_279 1273-0055 2.93 µM -0.313915993475564 0.386375932959619 no 2075 0.376792421459825 702 2847562 SGTC_781 4335-2806 94.4 µM -0.314639096132764 0.386078773650021 no 2076 0.376517845632856 719 845254 SGTC_1905 st060207 84.5 µM -0.315690548800082 0.385646798046105 no 2077 0.376118700547861 663 1948547 SGTC_1820 st053765 18.6 µM -0.315723918606893 0.385633090815213 no 2078 0.376106035102577 681 3690829 SGTC_215 1287-0124 461.5 µM -0.316423627359453 0.385345706146533 no 2079 0.375840492758997 687 5560863 SGTC_2758 dehydroepiandrosterone 69.35 µM -0.316842528670542 0.385173684939478 no 2080 0.375681546116367 720 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem] SGTC_1934 st074720 32.6 µM -0.318060270552585 0.384673749440942 no 2081 0.375219609715112 662 17250992 SGTC_2251 lansoprazole 556 µM -0.319850309328962 0.383939209650896 no 2082 0.374540903969181 716 3883 Gastric proton pump inhibitor. YBR192W RIM2 SGTC_2903 5923464 63.88 µM -0.320130139071824 0.383824419525985 no 2083 0.374434839623031 694 2876576 SGTC_551 k048-0028 34.9 µM -0.320305187744569 0.383752617262375 no 2084 0.37436849545533 721 6836383 SGTC_1813 st051246 8.6015 µM -0.32089449376314 0.383510922377238 no 2085 0.374145173398699 674 5291959 SGTC_2359 9039622 200 µM -0.321151601353652 0.383405487810731 no 2086 0.374047753722637 683 6463596 SGTC_915 methyl methanesulfonate (MMS) 110 mM -0.321171160577555 0.383397467326185 no 2087 0.374040342939379 694 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks. SGTC_2585 alliin 100 µM -0.321665160962543 0.383194913368782 no 2088 0.37385318685638 726 87310 A garlic compound which reacts with lipids. SGTC_1539 benzyladenosine 56 µM -0.322342303620895 0.382917317851291 no 2089 0.373596694152338 676 92208 A nucleotide analog. SGTC_64 000l-0018 272.079 µM -0.322350802362663 0.382913834162759 no 2090 0.373593475296579 699 6811119 SGTC_1932 st074806 40.9 µM -0.323718033952946 0.382353520708064 no 2091 0.373075758164138 681 17251235 SGTC_823 0417-1665 178 µM -0.324241065323811 0.382139239108398 no 2092 0.372877767173645 720 3429856 SGTC_2796 7949634 45.45 µM -0.326204471017028 0.381335170705268 no 2093 0.372134829436738 668 2971588 SGTC_460 trequinsin 123 µM -0.328083858057209 0.380565989696 no 2094 0.371424129263646 675 5537 A vasodilator. SGTC_3066 9117245 49.47 µM -0.328918922371024 0.380224372265221 no 2095 0.371108485703222 705 17176980 SGTC_1435 4092-0789 56.7 µM -0.329812669705272 0.379858851620296 no 2096 0.370770756758634 694 2248285 SGTC_1279 0874-0590 65.2 µM -0.330229331250149 0.379688483965602 no 2097 0.370613342837052 679 3523074 SGTC_2445 5742597 35.57 µM -0.330293987818857 0.379662048801724 no 2098 0.37058891765164 683 1774255 SGTC_2931 9014674 55.67 µM -0.331302008427061 0.379249987306678 no 2099 0.370208187194045 695 2996810 SGTC_1094 duloxetine 25.4 µM -0.331541228937568 0.379152218193276 no 2100 0.37011785200412 678 60834 A selective serotonin reuptake inhibitor. SGTC_2123 5259487 200 µM -0.33517954286094 0.377666200172549 no 2101 0.368744826407352 693 2173474 SGTC_709 3807-1509 243 µM -0.335839516317335 0.377396836500646 no 2102 0.368495944691939 719 1886677 YPL242C IQG1 SGTC_611 3453-1652 23.7 µM -0.33592433929329 0.377362220902496 no 2103 0.368463961209979 699 1560575 SGTC_805 3852-0218 479 µM -0.337016533981032 0.376916592837632 no 2104 0.368052218085246 697 6615355 SGTC_816 0325-0417 81.3 µM -0.337016993542224 0.376916405365809 no 2105 0.368052044868544 692 68101 SGTC_519 k048-0011 62.8 µM -0.337892445026875 0.376559329405623 no 2106 0.367722120536789 683 6836379 SGTC_3080 9117754 49.47 µM -0.338769306061398 0.376201784369644 no 2107 0.367391762815233 722 9550191 SGTC_479 n-linoleoylglycine 10 µM -0.339589489963707 0.375867445889254 no 2108 0.367082847031192 721 6433346 An anti-infammatory. SGTC_1000 4048-0884 8.67 µM -0.340082508929072 0.375666517228008 no 2109 0.366897196721796 705 13040088 SGTC_1888 azatryptophan 97.5 µM -0.340188094014779 0.375623490668638 no 2110 0.366857441842538 696 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides SGTC_785 1270-0111 65.3 µM -0.340779206973842 0.375382637155395 no 2111 0.366634902473149 666 6741994 SGTC_29 0299-0004 12.984 µM -0.341258565350131 0.375187354562574 no 2112 0.366454468842737 708 16871 A napthoquinone isolated from Swertia calycina. SGTC_2423 st077119 87.2 µM -0.342080441228657 0.374852610520592 no 2113 0.366145178083926 675 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae). SGTC_2207 7258803 200 µM -0.342406629025057 0.374719782729184 no 2114 0.366022450219202 717 3666799 SGTC_2173 5763948 167 µM -0.34273959479797 0.374584210188562 no 2115 0.36589718628375 684 2867177 SGTC_1710 st031758 61.5 µM -0.343118015200704 0.374430148862113 no 2116 0.365754839369963 708 5394341 SGTC_2512 diallyl trisulfide 49.23 µM -0.343388913288705 0.374319873992896 no 2117 0.365652949483584 710 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent SGTC_90 0870-0863 4.608 µM -0.343391028907094 0.374319012825563 no 2118 0.365652153796846 716 1738164 SGTC_3223 9129970 49.47 µM -0.344101650958466 0.374029787988433 no 2119 0.365384920675723 678 17248386 SGTC_1647 st011722 22.4 µM -0.347069382852173 0.372822682199964 no 2120 0.364269597219828 711 2854783 SGTC_2032 5185112 25.99 µM -0.347675529489686 0.37257628903085 no 2121 0.364041938065202 684 5718189 SGTC_2560 caryophyllene 100 µM -0.349176246056222 0.371966485736567 no 2122 0.363478499069069 686 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor. SGTC_1537 2',6'-dihydroxyflavanone 78 µM -0.350156674781427 0.37156827020586 no 2123 0.363110559737185 689 5106787 A p450 inhibitor. SGTC_2561 acetosyringone 100 µM -0.350368471912718 0.371482263722308 no 2124 0.363031092214487 717 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent. SGTC_3335 9143315 29.6265 µM -0.350378101065434 0.371478353672761 no 2125 0.363027479440174 679 4899691 SGTC_3196 9111891 49.47 µM -0.350841901523059 0.371290036844742 no 2126 0.362853479982232 713 18891510 SGTC_1550 gossypolone 36.6 µM -0.353308017728479 0.370289238500745 no 2127 0.36192876768246 701 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_2601 securinine 100 µM -0.353799628587351 0.370089837843709 no 2128 0.361744525929257 694 442872 A GABA receptor antagonist. SGTC_135 0933-0004 26.348 µM -0.354829988755405 0.369672030184171 no 2129 0.361358480276403 700 21230617 YGL099W LSG1 SGTC_2299 7976368 114.88 µM -0.355410123020084 0.369436855302174 no 2130 0.361141183099588 704 2979718 SGTC_2322 7413319 38.22 µM -0.356147222243976 0.369138120415188 no 2131 0.360865157191734 706 1840400 SGTC_271 rotenone 740 µM -0.35665568560386 0.368932094142027 no 2132 0.360674792127985 738 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria. SGTC_1140 3229-1848 2.98 µM -0.358439740972 0.368209503916466 no 2133 0.360007127818774 723 2849525 SGTC_256 clotrimazole 625 nM -0.35910016661423 0.367942131871816 no 2134 0.359760078484469 683 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C SGTC_1763 st044482 94.5 µM -0.359158940196065 0.367918340598663 no 2135 0.35973809553972 719 88505 SGTC_641 4092-0595 30 µM -0.359470430647535 0.367792259170254 no 2136 0.359621597246076 694 786260 SGTC_1214 0358-0031 63.7 µM -0.359479210447741 0.367788705592705 no 2137 0.359618313765387 737 4301366 SGTC_926 2268-1401 59.4 µM -0.362111596276764 0.366723773020232 no 2138 0.358634319147526 717 2931578 SGTC_2784 7567673 72.73 µM -0.36268995282587 0.366489935744552 no 2139 0.358418252948123 711 3471247 SGTC_907 3448-6986 75.5 µM -0.363285085590899 0.366249367350691 no 2140 0.358195966690591 721 590582 SGTC_1006 4099-6547 255 µM -0.364367202801727 0.365812081690838 no 2141 0.357791911501885 702 3146833 SGTC_2217 6934799 96.0675 µM -0.364494164970883 0.365760787445715 no 2142 0.357744515126081 714 675606 SGTC_921 1561-0023 372 µM -0.364957574014962 0.365573584984098 no 2143 0.35757153804478 710 24050882 SGTC_1014 4130-3005 69.3 µM -0.365002011631234 0.365555635287046 no 2144 0.357554952315126 720 743608 SGTC_1086 cerivastatin 2.18 µM -0.365403735227757 0.365393380343342 no 2145 0.357405026714851 689 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7 SGTC_1135 dihydrocapsaicin 536.708 nM -0.365537649226725 0.365339298236543 no 2146 0.357355054115218 719 107982 A Capsaicinoid. SGTC_2904 7225135 42.03 µM -0.365982987139161 0.365159464664094 no 2147 0.357188885254885 724 4446116 SGTC_2507 purpurin 79.67 µM -0.367053089827574 0.364727463769619 no 2148 0.356789708791775 678 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1 SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM -0.368145583411386 0.36428660078293 no 2149 0.356382341652204 687 6708739 YPR165W RHO1 SGTC_678 1218-2179 85.9 µM -0.368426807214846 0.364173145238033 no 2150 0.356277505894931 707 6820081 YOR116C RPO31 SGTC_577 r071-0003 38.6 µM -0.368613677227522 0.364097761902928 no 2151 0.356207849735049 694 4568517 YMR134W ERG29 SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM -0.369068899288123 0.363914147403003 no 2152 0.356038184912875 747 6708760 SGTC_720 r052-1644 49.9 µM -0.369141277703197 0.363884956338388 no 2153 0.356011211536913 724 1422863 YOR257W CDC31 SGTC_75 0159-0059 199.013 µM -0.370059742495625 0.363514597368861 no 2154 0.355668988479118 749 5377270 SGTC_1439 4092-1168 46 µM -0.37132451293199 0.363004803925534 no 2155 0.35519792116842 711 2886240 SGTC_476 mead acid 10 µM -0.374831706624105 0.361592424462598 no 2156 0.353892816050849 708 5312531 An omega 9 fatty acid. SGTC_876 0720-0963 56.8 µM -0.375151538852782 0.361463718492164 no 2157 0.353773884434252 753 765861 SGTC_3353 9151644 39.2805 µM -0.375335533896571 0.361389682834849 no 2158 0.353705471190287 710 4909158 SGTC_997 3996-0078 137 µM -0.377824274279267 0.360388778040203 no 2159 0.352780569894745 707 735687 SGTC_2830 7992007 71.43 µM -0.377825370769093 0.360388337271527 no 2160 0.352780162592732 714 1952075 SGTC_3088 9117578 49.47 µM -0.379678894994717 0.359643520409011 no 2161 0.352091894213605 709 678341 SGTC_168 3970-0862 530.542 µM -0.381082988146086 0.359079656630323 no 2162 0.351570835100748 708 3135186 SGTC_2042 p-Dimethylaminoacetophenone 200 µM -0.384345777495021 0.357770553804646 no 2163 0.350361091548534 718 75037 A free radical scavenger. SGTC_485 niflumic acid 177 µM -0.385100908892966 0.357467816068189 no 2164 0.350081327324261 716 4488 A COX2 inhibitor. SGTC_3302 9125395 16.351 µM -0.385384045078777 0.357354327791077 no 2165 0.349976450811956 706 17599668 SGTC_3257 9139206 32.98 µM -0.386012662576089 0.357102406813456 no 2166 0.349743645437428 725 4910041 SGTC_1164 k060-0068 93.7 µM -0.38781411462436 0.356380813029574 no 2167 0.349076799741412 702 5963676 SGTC_2120 5538279 151.968 µM -0.388484043563022 0.356112595698815 no 2168 0.348828930032165 717 2058197 SGTC_1733 st037357 54.9 µM -0.389169219410384 0.355838347642287 no 2169 0.348575485778472 750 1272339 YGL099W LSG1 SGTC_3123 9126162 49.47 µM -0.389197955476036 0.355826847391377 no 2170 0.348564857879616 675 25239884 SGTC_257 daunorubicin 18.5 µM -0.389219451727463 0.355818244619413 no 2171 0.348556907669746 719 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_1965 Pectolinarigenin 58.4 µM -0.389935746208582 0.355531626506888 no 2172 0.348292030167156 713 5320438 An anti-inflammatory. SGTC_1316 1272-0050 65.9 µM -0.389950775198084 0.355525613680485 no 2173 0.348286473410721 738 7340392 SGTC_1218 1348-1416 30.7 µM -0.390226811026958 0.355415183142868 no 2174 0.348184418857797 713 6787668 SGTC_2078 5212016 200 µM -0.390811737442036 0.355181218357018 no 2175 0.347968199193326 735 1899708 SGTC_1354 1498-1681 81 µM -0.39152051919031 0.354897785810189 no 2176 0.347706262295208 728 5754243 SGTC_104 0074-0074 590.992 µM -0.392085676956374 0.354671844137926 no 2177 0.347497455051845 719 3943124 SGTC_797 k781-0471 270 µM -0.392174550437608 0.354636318490768 no 2178 0.347464623426026 687 23738129 SGTC_2007 4011539 71.82 µM -0.392553522195801 0.354484845235389 no 2179 0.347324636591526 714 45595301 SGTC_1900 st060200 72.8 µM -0.392608238960438 0.354462977098675 no 2180 0.347304426708599 694 688945 SGTC_630 4356-0227 183 µM -0.392883631926285 0.354352920657183 no 2181 0.347202715671461 736 779312 SGTC_1629 st005085 44.9 µM -0.393515225676875 0.354100560150166 no 2182 0.346969490370074 734 24207091 SGTC_497 capsazepine 133 µM -0.393564395893656 0.354080916314327 no 2183 0.346951335973523 691 2733484 A calcium channel blocker. SGTC_3356 9151811 4.48 µM -0.395071058008213 0.353479183042196 no 2184 0.346395223749937 718 1859254 YPR165W RHO1 SGTC_2749 bexarotene 57.39 µM -0.39568190731518 0.353235325199714 no 2185 0.346169852178779 710 82146 An retinoic acid receptor inhibitor. SGTC_291 SEC14.278 35.5 µM -0.398491169789084 0.352114613396396 no 2186 0.345134083004403 710 1068044 SGTC_1816 st051957 91.6 µM -0.398628320311211 0.352059932093599 no 2187 0.345083545508429 736 674121 SGTC_2114 5491910 81.25 µM -0.398693112373521 0.352034100850543 no 2188 0.345059671761892 732 2849228 SGTC_3005 9076496 71.4286 µM -0.398991730222104 0.351915056973362 no 2189 0.34494964886665 728 21368410 SGTC_886 0866-0150 153 µM -0.399123983517477 0.351862338890824 no 2190 0.344900925590392 715 271463 SGTC_616 4092-0450 108 µM -0.400006876571778 0.351510477916529 no 2191 0.344575725957105 718 787165 SGTC_3194 9111903 49.47 µM -0.40174342221065 0.350818780579061 no 2192 0.343936432193569 757 17087251 SGTC_1637 st007924 17.4 µM -0.403859906841868 0.349976414986596 no 2193 0.343157870279177 698 683336 SGTC_1874 staurosporine 7.6 µM -0.403909480286263 0.349956693472238 no 2194 0.343139642343603 744 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1 SGTC_1993 st073995 70.8 µM -0.405464462979601 0.349338289477877 no 2195 0.342568067574127 703 3098394 SGTC_984 1492-0255 2.91 µM -0.405481428548159 0.349331544610516 no 2196 0.342561833418014 730 1585198 SGTC_367 0335-0881 7.1 µM -0.40583503504493 0.349190974896423 no 2197 0.342431907183091 753 23828853 SGTC_668 1682-0499 62.6 µM -0.406114489069955 0.349079897757893 no 2198 0.342329240105238 719 682214 SGTC_2894 9048625 32.47 µM -0.406462122500298 0.348941738775751 no 2199 0.342201541232905 745 4092861 SGTC_727 3032-0951 202 µM -0.407849465604262 0.348390570455515 no 2200 0.341692097586644 729 3652836 SGTC_1572 epiandrosterone 68.9 µM -0.40815529930818 0.34826911081909 no 2201 0.341579831705754 713 441302 A steroid. SGTC_492 tmb-8 126 µM -0.40839191382894 0.348175151753908 no 2202 0.341492984517431 720 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1 SGTC_2470 5664817 21.68 µM -0.410433502548618 0.347364829325479 no 2203 0.340743987121097 734 2859561 SGTC_2912 7964298 10.93 µM -0.410879842459882 0.34718776628378 no 2204 0.340580321933307 730 2975850 SGTC_1953 st076800 12.1 µM -0.41318310222083 0.346274593989138 no 2205 0.339736233724396 722 297591 SGTC_2330 7979373 200 µM -0.414757087118061 0.345651070189977 no 2206 0.339159868462244 711 1863007 SGTC_1128 3448-9350 235 µM -0.415163342371777 0.345490202712798 no 2207 0.339011166040866 687 619386 SGTC_294 k038-0071 157 µM -0.415388005985638 0.345401253212216 no 2208 0.338928942737628 732 24152826 SGTC_2817 7995342 71.43 µM -0.415924861100005 0.345188734487403 no 2209 0.338732493400067 755 18879975 SGTC_2233 sulbentine 40.3845 µM -0.416520472461722 0.344953013712056 no 2210 0.338514594939489 731 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58 SGTC_2581 avocatin a 64 µM -0.416536926127778 0.344946502817861 no 2211 0.338508576297197 766 6710728 A skin care supplement. SGTC_293 4049-0273 38.5 µM -0.417027779329054 0.344752288001856 no 2212 0.338329044416993 722 1380311 SGTC_553 k007-0256 45.7 µM -0.418719532011084 0.344083229626794 no 2213 0.337710559668426 740 6287000 SGTC_2266 7929956 200 µM -0.418720210433691 0.34408296142032 no 2214 0.337710311732907 738 2967153 SGTC_181 1447-1644 8.07 µM -0.41882679325736 0.344040826117042 no 2215 0.337671360975668 751 534600 SGTC_2478 5763493 32.33 µM -0.419630617149008 0.343723113459614 no 2216 0.337377659079031 704 1365576 YLR208W SEC13 SGTC_684 1140-0066 328 µM -0.4197117121741 0.343691066647513 no 2217 0.337348034003777 740 6813534 SGTC_1136 pergolide 1.05886 µM -0.421236219293915 0.343088827201157 no 2218 0.336791299403441 739 47811 A dopamine receptor agonist. SGTC_761 k216-0224 480 µM -0.421716628645199 0.34289912934483 no 2219 0.336615932770713 782 1340404 SGTC_2132 5317594 122.667 µM -0.422098861346958 0.34274822650225 no 2220 0.336476429509453 727 794577 SGTC_2715 st079500 56.4 µM -0.424132882949832 0.34194563122768 no 2221 0.335734452689982 735 28246688 SGTC_1530 rhein 70.4 µM -0.424324642546123 0.341870002445837 no 2222 0.335664534983498 709 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death. SGTC_2539 epi(13)torulosol 80 µM -0.425667454213838 0.341340583886312 no 2223 0.335175090256256 750 6708597 SGTC_272 doxorubicin 8.13 µM -0.426398598202375 0.341052453325532 no 2224 0.334908711339574 708 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_3043 9092303 49.47 µM -0.426422559344269 0.341043012242244 no 2225 0.334899982941063 724 25236084 SGTC_1450 4112-4260 37.6 µM -0.427650355019496 0.340559373917644 no 2226 0.334452849509731 732 1633175 SGTC_3109 9122853 49.47 µM -0.427780766942695 0.340508019021989 no 2227 0.334405370427187 746 1234709 SGTC_3120 9124077 49.47 µM -0.429038896654122 0.340012732265074 no 2228 0.333947459143257 732 18774327 YGL155W CDC43 SGTC_2766 oltipraz 83.91 µM -0.429739637168991 0.33973699200255 no 2229 0.333692523398233 756 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40 SGTC_2425 5628681 7.85 µM -0.431151034751121 0.339181869714874 no 2230 0.333179277280896 743 5714958 SGTC_2936 9038235 15.59 µM -0.431806789945257 0.338924070718824 no 2231 0.332940922088555 719 4749415 SGTC_1770 st043884 66.3 µM -0.434354929180268 0.337923030002475 no 2232 0.332015360763314 758 670149 SGTC_2815 7968870 71.43 µM -0.436494712735198 0.337083296651787 no 2233 0.331238917257388 754 2977326 YHR190W ERG9 SGTC_2546 rhodinyl acetate 100 µM -0.436742403631384 0.336986145524077 no 2234 0.331149086703203 725 6708682 SGTC_1724 st037281 8.293 µM -0.437409972803568 0.336724360838296 no 2235 0.330907026451713 705 574124 YDL195W SEC31 SGTC_3239 9133757 49.47 µM -0.437723886109532 0.336601288274628 no 2236 0.330793226066495 747 17036923 SGTC_3074 9116018 49.47 µM -0.438875114458856 0.336150088600117 no 2237 0.330376014695871 755 17027303 SGTC_1413 3910-0535 34.4 µM -0.441812416139218 0.334999945403565 no 2238 0.329312476547806 730 2876951 SGTC_2053 5265679 138 µM -0.444747512032734 0.333852209445606 no 2239 0.328251114811817 726 764595 SGTC_560 2332-1943 155 µM -0.444988978457665 0.333757855717056 no 2240 0.328163859536332 753 21177716 SGTC_1025 k007-0731 70 µM -0.44576299285432 0.333455478147883 no 2241 0.327884228212144 720 6256118 SGTC_1507 4075-3230 155 µM -0.447385565378112 0.332821952918272 no 2242 0.327298348070646 756 659771 SGTC_2540 epiandrosterone 100 µM -0.44745030061712 0.332796687255105 no 2243 0.327274982215642 731 441302 A steroid. SGTC_3141 9094609 49.47 µM -0.447680440567922 0.332706871560377 no 2244 0.327191919852387 748 25236309 YDL196W YDL196W SGTC_224 benfluorex 43.875 µM -0.449024155304121 0.33218265780097 no 2245 0.326707115814422 749 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis. SGTC_478 N-arachidonylglycine 10 µM -0.450253467110934 0.331703362660738 no 2246 0.326263843772621 710 5283389 SGTC_3146 9095609 49.47 µM -0.450567593311389 0.33158093245556 no 2247 0.326150613737545 726 17173999 SGTC_2648 atorvastatin 78.68 µM -0.453306835351132 0.330514080744055 no 2248 0.325163905758485 755 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11 SGTC_1129 3453-1384 223 µM -0.453608695864861 0.330396599231812 no 2249 0.32505524675971 787 1084452 SGTC_1903 st060211 78.3 µM -0.454375895796054 0.330098086869143 no 2250 0.324779149172831 733 688960 SGTC_2056 5235370 200 µM -0.456472168237245 0.329282993104719 no 2251 0.324025240063806 738 5511916 SGTC_384 k007-0144 5.16 µM -0.456845360535438 0.329137969618038 no 2252 0.323891099708396 725 6824886 SGTC_1170 0310-0127 64.8 µM -0.456904982880225 0.329114802602809 no 2253 0.323869671152467 771 774975 SGTC_1626 st003712 1.76 µM -0.457567441299769 0.328857440187962 no 2254 0.323631619716353 772 24207035 SGTC_2483 5729050 27.16 µM -0.458668965308387 0.328429682211289 no 2255 0.323235951807644 763 2865180 SGTC_509 pifithrin 175 µM -0.459834004794177 0.327977503685642 no 2256 0.322817686592332 757 4817 A p53 inhibitor. SGTC_2923 7992654 58.14 µM -0.460705432609605 0.327639447293699 no 2257 0.322504978429511 713 2985126 SGTC_188 3229-0966 278.469 µM -0.461332534739661 0.327396260490132 no 2258 0.322280023151859 747 5722370 SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM -0.461958769125619 0.327153483267497 no 2259 0.322055444088736 738 676296 Flavone; oxidizing agent. SGTC_714 4296-0578 26.1 µM -0.462291268065678 0.327024610490591 no 2260 0.321936230306699 742 1589775 SGTC_477 mead ethanolamide 10 µM -0.462330568892924 0.327009379303221 no 2261 0.321922140644625 721 16061185 SGTC_122 0236-0016 402.397 µM -0.462504106144371 0.326942127716918 no 2262 0.321859929208033 764 6808838 SGTC_2725 haloperidol 53.21 µM -0.463235770329943 0.326658644786617 no 2263 0.321597689551507 747 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_972 1319-0219 195 µM -0.464101147703315 0.326323483899836 no 2264 0.321287639759504 759 23903702 SGTC_2833 9001315 45.46 µM -0.464815194471696 0.32604703894329 no 2265 0.321031902850734 718 2989378 SGTC_2887 9044784 58.44 µM -0.465422170988571 0.325812121642587 no 2266 0.320814580038228 741 6465546 SGTC_3050 9093513 49.47 µM -0.465816780404301 0.325659433574586 no 2267 0.320673326394161 756 25236664 SGTC_366 0181-0206 4.31 µM -0.465996980407185 0.325589717669241 no 2268 0.320608830973981 761 274874 SGTC_3269 9137823 49.47 µM -0.466044048059842 0.325571509107011 no 2269 0.320591985872658 727 17682936 SGTC_2961 9083290 32.55 µM -0.467759295835051 0.324908233709026 no 2270 0.319978366016394 759 17741490 SGTC_2909 7941780 10.49 µM -0.469454143859042 0.324253391463068 no 2271 0.319372527425531 755 1243215 SGTC_1085 doxorubicin 7.67 µM -0.471428686637946 0.323491168063394 no 2272 0.318667317218841 766 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_175 3793-3120 23.7 µM -0.472115757998221 0.323226114555222 no 2273 0.318422082669762 797 5322297 SGTC_786 4544-0069 423 µM -0.472540014532845 0.323062492674322 no 2274 0.318270693629112 718 748821 YLR208W SEC13 SGTC_2658 polymyxin b sulfate 77.05 µM -0.473093033426918 0.322849262754379 no 2275 0.318073403399435 740 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides.  YIL048W NEO1 SGTC_934 2950-0684 338 µM -0.473707109533497 0.322612558958267 no 2276 0.317854391401521 763 1121253 SGTC_1869 3',7'-dimethoxyflavone 40.3 µM -0.474239699044326 0.32240732344656 no 2277 0.317664493409752 732 688664 SGTC_3159 9100096 49.47 µM -0.474257946774724 0.322400292568687 no 2278 0.317657987921258 709 25236875 SGTC_3019 9081971 49.47 µM -0.4749372800395 0.322138589666214 no 2279 0.317415839262785 745 16451803 SGTC_2855 9016525 58.44 µM -0.475348117198474 0.321980363611963 no 2280 0.317269434065946 731 43811474 SGTC_1142 3253-1408 9.78 µM -0.475455657435535 0.321938951878973 no 2281 0.317231115939293 760 256655 SGTC_236 1509-0011 5.31 µM -0.475511406378188 0.321917484874571 no 2282 0.317211252563645 786 3107280 SGTC_69 0096-0274 206.684 µM -0.475817135756552 0.321799769552021 no 2283 0.317102330399076 780 6741392 SGTC_1814 st052110 31.539 µM -0.4759503293892 0.321748491451538 no 2284 0.317054882475835 765 674163 SGTC_1687 st020778 55.3625 µM -0.476009579399853 0.321725681932595 no 2285 0.317033776652961 729 4259299 SGTC_1893 st059353 36.1 µM -0.476038765388645 0.321714446428629 no 2286 0.317023380345216 801 3112488 SGTC_1304 1165-0502 251 µM -0.47679057253913 0.321425085271364 no 2287 0.316755629779433 735 767425 SGTC_2224 6650123 117.647 µM -0.476961029903421 0.3213594934267 no 2288 0.316694935988389 747 2908370 SGTC_118 0083-0097 135.343 µM -0.476982526165853 0.321351222079239 no 2289 0.316687282285964 765 5207356 SGTC_1949 st076024 69.1 µM -0.477351878376974 0.321209116309555 no 2290 0.316555787410182 763 2921930 SGTC_3059 1327-0034 3 µM -0.477434693823701 0.321177257217148 no 2291 0.316526307061635 734 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_1995 st072814 61.1 µM -0.477531822012296 0.321139893691559 no 2292 0.316491733199268 728 5769371 SGTC_2563 tomatine 8.54 µM -0.47855500258275 0.320746403974099 no 2293 0.316127618129941 803 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties. SGTC_2365 9042475 200 µM -0.47857021925311 0.320740553540528 no 2294 0.316122204380331 737 6464479 SGTC_1952 st077036 64.1 µM -0.478954882114854 0.320592674971477 no 2295 0.315985363069556 761 2937007 SGTC_1673 st016611 27.3 µM -0.479086950484165 0.320541909591631 no 2296 0.315938386418843 782 5226799 SGTC_1784 st039334 36.3 µM -0.479285682634434 0.320465525839749 no 2297 0.315867703097185 766 3496984 SGTC_2883 9059145 45.46 µM -0.481532210697201 0.3196025903835 no 2298 0.315069146258274 778 16476510 SGTC_3192 9110362 49.47 µM -0.481545184726064 0.319597609634405 no 2299 0.315064536980002 756 16649480 SGTC_3135 9127742 49.47 µM -0.482603915408772 0.319191271081276 no 2300 0.314688499245732 739 3643468 SGTC_1723 st034307 2.5525 µM -0.484786786733486 0.318354175470915 no 2301 0.313913798260845 740 867466 SGTC_2797 7859098 81.82 µM -0.485337984375722 0.318142946514477 no 2302 0.313718307691356 740 972681 SGTC_418 lividomycin a 100 µM -0.485803377859746 0.317964645307938 no 2303 0.313553289574552 740 72394 An antibiotic. SGTC_859 0439-0102 54.6 µM -0.485988950101361 0.317893560771244 no 2304 0.313487500211237 761 610143 SGTC_3052 9092717 49.47 µM -0.487387967789758 0.317357874957254 no 2305 0.312991709346214 782 25237534 SGTC_891 0929-0073 133 µM -0.487961353703328 0.317138435092287 no 2306 0.312788607581866 780 5603632 SGTC_831 k061-1017 217 µM -0.488612903505751 0.316889159241163 no 2307 0.31255788797972 754 1240153 SGTC_928 2764-0428 58.7 µM -0.489151862896903 0.316683022047174 no 2308 0.312367093143987 770 662578 SGTC_3148 9097893 49.47 µM -0.490404158549187 0.316204273124788 no 2309 0.311923967285331 724 17174100 SGTC_98 0074-0023 107.663 µM -0.491403803494833 0.315822332795063 no 2310 0.311570437324178 773 3563821 SGTC_3228 9131799 49.47 µM -0.491606700366116 0.315744834757128 no 2311 0.311498702911519 754 17015818 SGTC_1336 1486-0901 104 µM -0.491907158046179 0.315630087489035 no 2312 0.311392488910383 740 5006114 SGTC_2724 maprotiline 69.64 µM -0.493415420103179 0.315054338467604 no 2313 0.31085954449443 761 4011 A tricyclic antidepressant. SGTC_2438 5259590 200 µM -0.494457111728871 0.314656955489073 no 2314 0.310491694162364 764 1201127 SGTC_2603 homopterocarpin 100 µM -0.495974000866246 0.314078678663472 no 2315 0.309956377177059 752 101795 A weak amylase inhibitor. SGTC_1766 st045414 44.774 µM -0.496523666496095 0.313869244634399 no 2316 0.309762497033299 768 253960 SGTC_2281 7943571 200 µM -0.496780543616127 0.313771389664006 no 2317 0.309671908499514 770 1244024 SGTC_430 0958-0115 16.4 µM -0.497465352030853 0.313510582233927 no 2318 0.3094304651297 747 6833180 SGTC_734 2023-0417 80 µM -0.497923678165718 0.313336082022001 no 2319 0.309268918705034 769 3935732 SGTC_3006 9075424 71.4286 µM -0.499758676096571 0.31263785525624 no 2320 0.308622505630112 759 7465181 SGTC_2464 5717415 7.67 µM -0.501214960143786 0.312084209213305 no 2321 0.308109923388226 754 5285744 SGTC_1747 st037496 66.6 µM -0.502625426792741 0.311548386217898 no 2322 0.307613824464515 770 723305 SGTC_863 0466-0191 129 µM -0.502819550513564 0.311474671644226 no 2323 0.307545573456234 776 765160 YPR165W RHO1 SGTC_1504 k297-0033 30 µM -0.503623741777816 0.311169376727767 no 2324 0.307262902770379 721 4388117 SGTC_1930 st074634 34.3 µM -0.504020505192167 0.31101880136519 no 2325 0.307123483843183 781 684253 YOR116C RPO31 SGTC_621 3584-0052 32.1 µM -0.505813824570018 0.310338615044403 no 2326 0.306493676304945 775 2273927 SGTC_1684 st024538 14.6195 µM -0.506817140693752 0.309958350866581 no 2327 0.306141564177719 756 6732859 SGTC_2917 7979103 53.79 µM -0.506952419751855 0.309907094647961 no 2328 0.306094101905896 775 2980565 SGTC_3126 9127922 49.47 µM -0.507386068198365 0.309742813418866 no 2329 0.305941979527989 812 45595682 SGTC_2665 lovastatin 100 µM -0.5093339907129 0.309005341119257 no 2330 0.305259068150582 768 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1 SGTC_1433 4060-0023 7.6 µM -0.509393342227558 0.30898288303645 no 2331 0.305238271053038 743 3840627 SGTC_2779 methotrexate 400 µM -0.510277414561801 0.308648442531373 no 2332 0.304928561704744 751 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2 SGTC_2387 9077560 195.08 µM -0.510410392502887 0.308598151307528 no 2333 0.304881988783909 739 5303272 SGTC_2558 carylophyllene oxide 100 µM -0.511813139878828 0.308067861984885 no 2334 0.304390896632416 788 6708694 An oxygenated terpenoid and antifungal agent. SGTC_2836 9010338 19.48 µM -0.512936155485771 0.307643609951406 no 2335 0.303997990635195 732 2994051 SGTC_268 camptothecin 39.6153 µM -0.514333917958659 0.307115923426162 no 2336 0.303509275910184 782 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_2388 9080168 200 µM -0.514405485449747 0.307088915835701 no 2337 0.303484262444495 776 15943073 SGTC_1050 3232-1156 69.3 µM -0.515166165783356 0.306801920831616 no 2338 0.303218454925354 780 700529 SGTC_812 4251-0442 148 µM -0.515222598370102 0.306780634250131 no 2339 0.303198739612976 772 5723007 SGTC_1224 0823-0416 294 µM -0.516787449990455 0.30619062614421 no 2340 0.302652270883343 775 3598164 SGTC_1190 1486-1332 13 µM -0.517937665748824 0.305757271589891 no 2341 0.302250880596441 775 4150046 SGTC_2517 totarol 10 µM -0.517996880146676 0.305734969364507 no 2342 0.302230223040905 764 460178 An antibacterial membrane disruptor. YGL001C ERG26 SGTC_3253 9135987 49.47 µM -0.518561488029737 0.305522354371073 no 2343 0.302033285568641 762 4182430 SGTC_1616 st002734 56.1 µM -0.518767743202074 0.305444700987988 no 2344 0.301961357319916 757 4026101 SGTC_635 k038-0028 24.7 µM -0.519825997063405 0.305046414795359 no 2345 0.301592429010687 784 4035102 SGTC_299 1273-0059 1.44 µM -0.520942350521488 0.304626512291936 no 2346 0.301203465943451 756 2848077 SGTC_647 0140-0236 81 µM -0.521257457394659 0.304508035289912 no 2347 0.301093716413392 763 990837 SGTC_1627 st003713 25.6 µM -0.521790989263316 0.304307479458721 no 2348 0.300907932079751 741 16195070 YER133W GLC7 SGTC_2027 5150920 200 µM -0.522692324610077 0.303968799165608 no 2349 0.300594190186966 761 786715 SGTC_1594 piperine 70.1 µM -0.522970841626296 0.30386417930375 no 2350 0.30049727229075 772 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_441 propafenone 146 µM -0.522980069077489 0.30386071345408 no 2351 0.300494061578908 759 4932 Slows the influx of sodium ions into the cardiac muscle. SGTC_48 0382-0018 55 µM -0.523509727391345 0.303661802262893 no 2352 0.300309791785106 751 762596 SGTC_245 methotrexate 289.6 µM -0.523731214935782 0.303578640685188 no 2353 0.300232750717784 747 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2 SGTC_96 0929-0093 37.281 µM -0.524560163468291 0.303267486986763 no 2354 0.29994449293363 758 6991579 SGTC_1695 st026914 34.495 µM -0.525293336914979 0.302992402248844 no 2355 0.299689644318248 769 3289191 SGTC_567 1080-0542 68.4 µM -0.52773398117832 0.302077484604103 no 2356 0.298841992214493 736 5950415 SGTC_1342 1486-1464 234 µM -0.527792106857609 0.302055710320099 no 2357 0.29882181806409 778 3253938 SGTC_2214 7179297 48.276 µM -0.528020656769362 0.30197010076738 no 2358 0.298742499396159 746 769744 SGTC_2754 granisetron 64.02 µM -0.528380136983268 0.301835469786213 no 2359 0.298617760493864 790 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients. SGTC_159 3970-0959 50 µM -0.528857969759962 0.301656555686262 no 2360 0.298451990169876 758 6615653 SGTC_1377 2944-0135 198 µM -0.529096238055317 0.301567359124809 no 2361 0.298369345493789 769 1894137 SGTC_3258 9138477 49.47 µM -0.529765399491847 0.301316919700699 no 2362 0.298137298874043 762 4970355 SGTC_1556 plumbagin 1.48 µM -0.530494808993342 0.301044038649393 no 2363 0.29788445358602 769 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_50 0929-0078 56.389 µM -0.531412789712841 0.300700769192284 no 2364 0.297566380285584 751 1377751 SGTC_166 k072-0058 166.424 µM -0.532240579855217 0.300391377131637 no 2365 0.29727969033908 786 5846229 SGTC_3036 9090181 49.47 µM -0.533178106002535 0.300041144312429 no 2366 0.296955147849407 774 25236586 SGTC_2036 5160441 105 µM -0.533524156223235 0.299911916591592 no 2367 0.296835396960444 782 134534 YIL048W NEO1 SGTC_407 eburnamonine 100 µM -0.534290187703201 0.299625942260162 no 2368 0.296570389949869 784 3195 SGTC_1052 3253-3998 198 µM -0.536265058783597 0.298889255258269 no 2369 0.295887687793278 760 5450317 SGTC_2922 7999257 32.47 µM -0.536752530492092 0.298707540183346 no 2370 0.295719282611619 784 2988377 SGTC_3157 9099274 49.47 µM -0.537159439841226 0.29855589485004 no 2371 0.295578742768693 776 17217662 SGTC_2440 5628896 157.78 µM -0.538651420976078 0.298000169173766 no 2372 0.295063699758903 791 5522048 SGTC_815 1582-0027 36.9 µM -0.539815810572893 0.297566790983318 no 2373 0.294662031204101 771 3128206 SGTC_331 k048-0133 24.5 µM -0.539960125198055 0.297513098068642 no 2374 0.29461226591324 758 6813582 SGTC_1632 st005650 90 µM -0.541170158340857 0.297063073859632 no 2375 0.294195152100693 763 2759605 SGTC_767 0929-0023 86 µM -0.542884213869747 0.296426131734969 no 2376 0.293604762805903 794 1204563 SGTC_2541 muurolladie-3-one 83.07 µM -0.543770337707904 0.296097094233075 no 2377 0.293299761550568 789 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils.  YMR203W TOM40 SGTC_1775 st081588 35.1725 µM -0.543874368078187 0.296058476437421 no 2378 0.293263964232754 802 1426443 YGL099W LSG1 SGTC_2529 gangaleoidin 93.61 µM -0.545232895368447 0.295554380961336 no 2379 0.292796674909844 791 4565183 SGTC_1055 3448-0672 86 µM -0.545452596173649 0.295472895811422 no 2380 0.292721137445128 774 748378 SGTC_1432 4049-0298 68.4 µM -0.545952406032227 0.295287559110303 no 2381 0.292549326692974 788 741646 SGTC_3152 9099253 49.47 µM -0.546117963132046 0.295226179949379 no 2382 0.292492426404901 780 25236131 SGTC_2842 9000675 19.48 µM -0.54687479528818 0.294945664431466 no 2383 0.292232376433498 768 2989072 SGTC_898 1000-0849 28.3 µM -0.54797092689687 0.294539607405495 no 2384 0.291855932892482 786 6751807 SGTC_1064 honokiol 6.76 µM -0.548546452590493 0.29432650983076 no 2385 0.291658371075132 788 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis. SGTC_2589 lobaric acid 100 µM -0.548846274700689 0.294215524122572 no 2386 0.291555475262628 774 73157 A novel microtubule depolymerizer. SGTC_1489 4065-0444 182 µM -0.549216936333243 0.294078342349081 no 2387 0.291428291471356 789 2877968 SGTC_2832 7992762 51.95 µM -0.54931689655928 0.294041352157582 no 2388 0.291393996910671 739 2985177 SGTC_2525 harmine 47.85 µM -0.549435100962411 0.293997613500467 no 2389 0.291353445530016 761 5280953 A monoamine oxidase inhibitor SGTC_1375 2910-0797 186 µM -0.550476883201802 0.293612257532291 no 2390 0.290996164076702 797 742508 SGTC_2456 5770359 74.46 µM -0.550733340291882 0.29351742975861 no 2391 0.290908242975872 803 3118787 SGTC_78 0336-0123 156.75 µM -0.550828019545893 0.293482424668905 no 2392 0.290875787256047 773 6765896 SGTC_1707 st032323 6.317 µM -0.553270989394704 0.29257987213577 no 2393 0.290038931521456 781 3132057 YMR211W DML1 SGTC_1773 st048542 73.5835 µM -0.554279116004787 0.292207797151416 no 2394 0.28969392025292 796 3237138 SGTC_1141 3253-0389 52.6 µM -0.554623289684454 0.29208082145295 no 2395 0.289576177779844 801 5402031 SGTC_2993 9054257 71.4286 µM -0.555776258608681 0.291655644857477 no 2396 0.28918190870721 784 6470217 YGL055W OLE1 SGTC_2205 7238770 200 µM -0.556427340251797 0.291415675131034 no 2397 0.288959376488319 769 279867 SGTC_1908 st060353 56.5 µM -0.556983188557868 0.291210878556611 no 2398 0.288769457708065 816 4227716 SGTC_1395 3486-0190 4.35 µM -0.557416842400793 0.29105114994639 no 2399 0.288621330391404 791 6748079 SGTC_2997 9067075 71.4286 µM -0.561522390617569 0.289540976713212 no 2400 0.287220735398954 790 27209819 SGTC_2427 5545055 42.75 µM -0.563146364193007 0.288944636114329 no 2401 0.286667611146117 774 5372858 SGTC_3022 9087993 49.47 µM -0.563203698412432 0.288923592937084 no 2402 0.286648092386166 786 17173644 SGTC_1547 harmine 94.2 µM -0.563272952445521 0.288898175834156 no 2403 0.286624516506438 771 5280953 A monoamine oxidase inhibitor YHR072W ERG7 SGTC_491 tetrandrine 80.3 µM -0.563414097797173 0.288846376969297 no 2404 0.286576469793457 790 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_2564 betulinic acid 100 µM -0.564632112254868 0.288399560163073 no 2405 0.286162009278174 805 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14 SGTC_113 0099-0221 2.5 µM -0.567052625768056 0.28751258666909 no 2406 0.285339213933607 793 89219 SGTC_2496 diffractaic acid 79.83 µM -0.567322036340558 0.287413943626468 no 2407 0.285247704026728 769 94870 An apoptosis inducer which activates caspases. SGTC_3191 9110352 49.47 µM -0.567702280695209 0.287274746715537 no 2408 0.285118571331314 794 17122424 SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM -0.568680583622961 0.286916763849861 no 2409 0.284786463386134 791 5711223 A potent inhibitor of glutathione S-transferases. SGTC_1699 st031318 29.054 µM -0.571161227623156 0.286009989541479 no 2410 0.283945178914089 779 5340658 SGTC_3332 9141069 11.198 µM -0.571239654116351 0.285981343754418 no 2411 0.283918600794951 791 17332883 SGTC_670 4204-0025 119 µM -0.571832166770981 0.285764968731427 no 2412 0.283717841422425 781 719039 SGTC_2587 piperic acid 92.2 µM -0.571906040059563 0.285737996988138 no 2413 0.283692815914043 786 5370536 SGTC_125 0133-0007 11.75 µM -0.573578025697345 0.285127865426537 no 2414 0.283126692628097 794 26541 SGTC_3207 9114163 49.47 µM -0.574156360334573 0.284916967457655 no 2415 0.282930998603956 833 849233 SGTC_203 k066-0004 30.888 µM -0.574294989273301 0.284866425496931 no 2416 0.282884099678606 786 6795412 SGTC_1192 1488-0095 21.4 µM -0.574900809471906 0.284645603053863 no 2417 0.282679191222536 806 915875 SGTC_131 0141-0277 33.849 µM -0.5750356434342 0.284596466977208 no 2418 0.282633595616724 809 1547771 SGTC_1184 1269-1718 139 µM -0.575702774535295 0.284353411249013 no 2419 0.28240804983285 779 5403821 SGTC_2144 5628481 200 µM -0.576159218647046 0.284187172240497 no 2420 0.282253783665581 784 2818399 SGTC_33 0986-0033 35.816 µM -0.576587203210126 0.284031340555438 no 2421 0.28210917293005 758 2848082 SGTC_1563 conessine 56.1 µM -0.578417182490742 0.283365495876147 no 2422 0.281491248044207 804 441082 An anti-amoebic, histamine inhibitor. SGTC_1209 2323-2347 50.3 µM -0.578871620989915 0.283200262837006 no 2423 0.281337900116291 785 5412760 SGTC_963 1269-2853 151 µM -0.57912716030881 0.28310736949778 no 2424 0.281251687407066 755 3668223 SGTC_3013 9080133 71.4286 µM -0.579185843130221 0.283086039255295 no 2425 0.281231891061102 784 17050193 SGTC_617 3770-0098 35 µM -0.579960514469657 0.282804531254875 no 2426 0.280970622779918 794 5962639 SGTC_2683 piperine 63.03 µM -0.580688535528166 0.282540098140351 no 2427 0.280725194896718 799 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_2018 5133068 143 µM -0.581600517080835 0.282209014386896 no 2428 0.280417897276128 812 785362 SGTC_321 4534-3890 65.3 µM -0.582414442603125 0.281913686460325 no 2429 0.280143777825907 791 699746 SGTC_989 1501-0895 10.3 µM -0.583371188612463 0.2815667274809 no 2430 0.279821724423555 802 2830112 SGTC_2970 9090938 41.86 µM -0.584560654643918 0.281135661199859 no 2431 0.279421584977506 762 17217104 SGTC_1030 k029-0042 36.7 µM -0.585056924834521 0.280955905588421 no 2432 0.279254720609085 781 6080581 SGTC_1107 amlodipine 47 µM -0.585369137746067 0.280842846424516 no 2433 0.279149767918579 773 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.  SGTC_3113 9123498 49.47 µM -0.58655240506468 0.280414559061771 no 2434 0.278752177959423 812 8897275 SGTC_3165 9101544 49.47 µM -0.587963704111508 0.279904148752129 no 2435 0.278278327744198 789 5002184 SGTC_543 3844-1095 191 µM -0.588320273813326 0.279775263112267 no 2436 0.278158669980199 800 4230703 SGTC_1911 st060208 74.3 µM -0.590012933564945 0.279163827591486 no 2437 0.277590989268321 805 688783 SGTC_3070 9117005 49.47 µM -0.591801076860338 0.27851860717822 no 2438 0.276991901009396 794 8779016 SGTC_701 4424-0219 185 µM -0.593983947792477 0.277731942183295 no 2439 0.27626142469767 802 2911779 SGTC_3108 9121785 49.47 µM -0.59499636276244 0.277367455875109 no 2440 0.275922951136994 785 17140271 SGTC_2367 9070478 135.38 µM -0.595299003375486 0.277258545621466 no 2441 0.275821810996174 776 572802 SGTC_1303 1160-0052 261 µM -0.595448025857881 0.277204925091498 no 2442 0.275772015535021 790 3562476 SGTC_1387 3342-1166 1.8 µM -0.595838450367308 0.277064468542625 no 2443 0.275641577190153 780 3418228 SGTC_357 1325-0123 420 µM -0.596547826361492 0.276809357279339 no 2444 0.275404656835977 815 1098503 SGTC_155 k072-0202 43.6 µM -0.598509339157366 0.276104542438421 no 2445 0.274750064634057 816 5857737 SGTC_1753 st043925 64 µM -0.599362791253494 0.275798153559879 no 2446 0.274465491962642 799 670181 SGTC_1902 st060212 70.5 µM -0.600719188096013 0.275311551802248 no 2447 0.274013518301871 776 688944 SGTC_1165 k072-0275 30.3 µM -0.600749661849557 0.275300624324227 no 2448 0.274003368173877 796 6153523 YGL055W OLE1 SGTC_2668 2',4'-dihydroxychalcone 15.08 µM -0.601301172011871 0.275102897099609 no 2449 0.273819704550997 828 5357218 A potent inhibitor of glutathione S-transferases. SGTC_2617 dihydrotanshinone i 20.83 µM -0.601839162428738 0.274910084382491 no 2450 0.27364060194248 802 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12 SGTC_3047 9092122 49.47 µM -0.602212986625163 0.274776147133499 no 2451 0.27351618611662 809 17173831 SGTC_1205 4161-2785 76 µM -0.603378428076718 0.274358788412843 no 2452 0.273128484768861 802 3498106 SGTC_1842 st055362 61.2 µM -0.606072029255395 0.273395376242915 no 2453 0.272233461891384 775 676032 SGTC_351 caspofungin 25 nM -0.606618879023264 0.273199990900936 no 2454 0.272051934207324 794 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1 SGTC_3304 9125678 46.087 µM -0.608859381787679 0.272400199087659 no 2455 0.271308824656588 807 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2 SGTC_2657 nystatin 74.44 µM -0.609637442391255 0.272122727261978 no 2456 0.271051001462727 792 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_1282 0886-0010 32.4 µM -0.609978193795395 0.272001252818222 no 2457 0.270938126366126 799 2836211 YNL267W PIK1 SGTC_2326 6164455 177.58 µM -0.612908537306633 0.270957729319133 no 2458 0.269968408972178 795 2888790 SGTC_2145 5634607 200 µM -0.613636135457264 0.270698934521509 no 2459 0.269727899643218 812 308662 SGTC_2475 5812728 15.03 µM -0.615133717761284 0.270166657669264 no 2460 0.26923320817138 806 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2 SGTC_1822 st052468 42 µM -0.615407608495482 0.270069366953422 no 2461 0.269142783990707 800 2873678 SGTC_3329 9141233 27.5565 µM -0.616148778420029 0.269806178531894 no 2462 0.268898165460467 814 4909101 YNL103W MET4 SGTC_2844 9010103 25.97 µM -0.617219286787048 0.269426269320116 no 2463 0.268545047995629 832 2480525 SGTC_801 0866-0028 10.1 µM -0.619213221096901 0.268719364157031 no 2464 0.267887951617356 806 6849771 SGTC_2492 derrusnin 100 µM -0.620960414464395 0.268100702425993 no 2465 0.267312834589278 820 1715307 Part of coumarin class of compounds. SGTC_2421 5690543 90.72 µM -0.622183717395717 0.267667971574973 no 2466 0.266910535702321 821 3397993 SGTC_2955 9076254 12.21 µM -0.623576463092026 0.267175730995233 no 2467 0.266452886016764 797 16459619 SGTC_2203 7227154 166.4 µM -0.623962002229312 0.26703955000894 no 2468 0.266326269856916 794 896304 SGTC_1643 st009866 20.2 µM -0.624145910029032 0.266974602039365 no 2469 0.266265882827362 791 3156273 YOR207C RET1 SGTC_3284 9108171 64.8615 µM -0.625870503246378 0.266365941679377 no 2470 0.265699941592363 800 8687505 SGTC_1843 st055809 45.5 µM -0.625977437449768 0.266328224542459 no 2471 0.265664870234505 810 16413835 SGTC_1819 st053448 58.6 µM -0.626183941853204 0.266255395302045 no 2472 0.26559714934535 838 2857616 SGTC_1091 telmisartan 47.6 µM -0.627415442343433 0.265821283494957 no 2473 0.265193473934291 826 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension. SGTC_1817 st052116 64.4 µM -0.627438773047564 0.265813062736175 no 2474 0.265185829335593 803 4361398 SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM -0.627887859267734 0.265654848758077 no 2475 0.265038702397457 817 23847180 SGTC_438 sphingosine 6.67 µM -0.628245979718739 0.265528716435606 no 2476 0.264921406847107 786 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes. SGTC_2465 5809242 33.21 µM -0.629262074499044 0.265171006786657 no 2477 0.264588747980941 845 2731748 SGTC_814 3342-0569 96 µM -0.629701906181522 0.265016242791449 no 2478 0.264444817589814 814 4346283 SGTC_2458 5808907 16.39 µM -0.630669485208568 0.264675941432844 no 2479 0.264128327622884 822 2731747 SGTC_3172 9105863 49.47 µM -0.630926039606307 0.264585747529579 no 2480 0.264044442416319 807 2348785 SGTC_3121 9125696 49.47 µM -0.631433928715684 0.26440724087566 no 2481 0.26387841872296 833 1235365 SGTC_1258 0671-0043 57.1 µM -0.632261657255983 0.264116452385724 no 2482 0.263607956918824 824 4298767 SGTC_1945 st075991 56.6 µM -0.632998979269213 0.263857561792015 no 2483 0.263367154775435 795 1084980 SGTC_170 4197-0004 226 µM -0.633618920785497 0.263639986338236 no 2484 0.263164774902768 825 218692 SGTC_1628 st004252 77.7 µM -0.634203029593453 0.263435070556129 no 2485 0.262974165337208 793 692968 SGTC_2920 7982904 15.77 µM -0.635076737259743 0.263128710167831 no 2486 0.262689184084322 809 6456808 SGTC_1127 asiatic acid 681.4 nM -0.635967013927611 0.262816727314776 no 2487 0.262398961054103 816 470603 A kinase inhibitor which arrests cells at G2/M. SGTC_1689 st020265 53.493 µM -0.639269546242665 0.261661063834704 no 2488 0.261323798133708 815 5758320 YPR016C TIF6 SGTC_1651 st011928 86.1 µM -0.639522233148359 0.261572747986473 no 2489 0.26124162740758 812 720198 SGTC_1994 st072947 40.9 µM -0.639967627111246 0.261417116930337 no 2490 0.261096823006387 828 5286565 YDL195W SEC31 SGTC_3233 9132340 49.47 µM -0.640904521905836 0.26108989929018 no 2491 0.260792358882822 854 17682950 SGTC_1474 0330-0125 5.35 µM -0.640997515469424 0.261057432069734 no 2492 0.260762148591323 817 X1474 SGTC_3099 9120367 49.47 µM -0.641326556753658 0.260942569217137 no 2493 0.260655269275036 823 24824940 SGTC_2143 5623677 140.463 µM -0.641535918214059 0.260869498136942 no 2494 0.26058727614418 794 5375313 SGTC_2857 9024691 58.44 µM -0.645434737864826 0.259510662478941 no 2495 0.259322748984278 835 16478292 SGTC_1241 0364-0022 50.8 µM -0.645931350080471 0.25933784358306 no 2496 0.259161907769373 823 4563895 SGTC_3220 9131269 49.47 µM -0.646349705884221 0.259192303739059 no 2497 0.259026452029061 823 17722206 SGTC_644 1498-1197 63.3 µM -0.64692544312379 0.258992082255388 no 2498 0.258840099022883 809 6741615 SGTC_2022 5136654 200 µM -0.650335754335558 0.257807736451706 no 2499 0.257737683269938 832 1713771 SGTC_712 r015-0009 80.6 µM -0.651808761485158 0.257297055546037 no 2500 0.257262274433362 813 6813872 YLR060W FRS1 SGTC_1111 tnp00062 510.699 nM -0.653011865847531 0.256880338413681 no 2501 0.256874314415547 811 676306 SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM -0.655005569604206 0.256190556790768 no 2502 0.256232084063784 833 4620898 SGTC_852 0418-0143 439 µM -0.655226686073881 0.256114114454053 no 2503 0.25616090758071 806 5369229 SGTC_2696 st077691 74.316 µM -0.656046206324295 0.255830901287819 no 2504 0.255897197324885 836 757133 SGTC_2814 7977482 42.97 µM -0.658392581612307 0.255020936210786 no 2505 0.255142950509114 820 6456762 SGTC_1007 4101-0031 70 µM -0.659554414344559 0.254620370558295 no 2506 0.254769908000091 831 1146276 SGTC_189 3970-0742 2.116 µM -0.659847795587175 0.254519273498997 no 2507 0.254675754011032 819 2891807 SGTC_1518 st038567 90.8 µM -0.660009927818879 0.254463412925538 no 2508 0.254623729204044 841 77966 SGTC_420 mitomycin C 81.9 mM -0.660433267793813 0.254317586878357 no 2509 0.254487914598262 814 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_1412 3909-8563 178 µM -0.661971130983309 0.253788214805625 no 2510 0.253994861718392 840 23767530 SGTC_2856 9022925 19.48 µM -0.662335400115042 0.253662908796765 no 2511 0.253878147197886 805 4944862 SGTC_1971 st069429 63.5 µM -0.662864163679544 0.253481075696727 no 2512 0.253708777547159 816 1246522 YGL099W LSG1 SGTC_3241 9133421 49.47 µM -0.66449891590308 0.252919344766881 no 2513 0.253185521280342 852 17018221 SGTC_2300 7976697 71.57 µM -0.664896366899499 0.252782872368008 no 2514 0.253058389824954 806 2236109 SGTC_2294 7971431 200 µM -0.665234904543044 0.252666659579165 no 2515 0.252950129298165 850 5741572 SGTC_258 haloperidol 50.781 µM -0.665447206614525 0.252593795142116 no 2516 0.252882249923252 837 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_1187 1391-0724 117 µM -0.666662797382345 0.252176804073661 no 2517 0.252493773583676 820 6997986 SGTC_1482 3346-2049 8.48 µM -0.666984113222218 0.252066641957244 no 2518 0.252391140609343 799 3826804 SGTC_798 1287-0182 476 µM -0.668340601707745 0.251601854161118 no 2519 0.251958100845904 845 1649755 SGTC_276 colchicine 750 µM -0.668360653196187 0.251594987107717 no 2520 0.251951702633921 834 2833 A microtubule depolymerizer. SGTC_2647 atorvastatin 60.16 µM -0.668800071083968 0.251444524084943 no 2521 0.251811510694333 804 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7 SGTC_942 3253-1115 227 µM -0.66927558464334 0.251281754974225 no 2522 0.251659849196172 855 46497897 SGTC_1324 1418-0026 34.4 µM -0.669505600439112 0.251203040167618 no 2523 0.251586504692659 822 1372513 SGTC_821 1114-0266 29.2 µM -0.670376443706228 0.2509051429077 no 2524 0.251308923638497 816 3123235 SGTC_1056 3448-1962 115 µM -0.672315858868161 0.250242382055545 no 2525 0.250691317895864 821 715507 SGTC_2198 6589944 200 µM -0.674732827533711 0.249417726889131 no 2526 0.249922762049388 812 5290268 SGTC_3010 9080089 71.4286 µM -0.675261914771815 0.249237398398553 no 2527 0.249754688098817 811 17027233 SGTC_23 0213-0011 39.996 µM -0.675464576953961 0.249168343535316 no 2528 0.249690324761516 838 627608 SGTC_1247 0448-0043 5.84 µM -0.675945867446437 0.249004389990635 no 2529 0.249537507366777 828 3089013 YGL099W LSG1 SGTC_1549 4'-methoxyflavonol 74.6 µM -0.676241004194781 0.248903878869725 no 2530 0.249443821335353 820 97141 SGTC_1546 5-methoxyflavanone 78.7 µM -0.676644193486265 0.248766604520698 no 2531 0.249315866119577 810 147795 SGTC_47 0149-0135 24.25 µM -0.678887218576855 0.24800365554905 no 2532 0.248604662411543 821 5239155 SGTC_752 1896-0090 130 µM -0.679661409644851 0.247740610116721 no 2533 0.248359438097929 828 772567 SGTC_3134 9127454 49.47 µM -0.679672319214665 0.247736904457602 no 2534 0.248355983423185 834 24262820 SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM -0.679996139401497 0.247626925768943 no 2535 0.248253452693281 836 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair. SGTC_748 act1.228 77.9 µM -0.68065151500219 0.247404421108309 no 2536 0.248046011123269 815 4421505 YNR035C ARC35 SGTC_44 0929-0055 61.211 µM -0.68097693397156 0.247293978776691 no 2537 0.247943042846431 819 1379590 SGTC_902 1120-0002 2.07 µM -0.681509996821468 0.24711312218409 no 2538 0.247774421699327 817 3280475 SGTC_1039 k821-0043 94 µM -0.681775122961346 0.24702319702194 no 2539 0.247690578457406 810 15992768 SGTC_11 0438-0307 1.3 µM -0.684237483562964 0.246188853604028 no 2540 0.24691260820316 832 4011476 SGTC_2371 9071574 200 µM -0.686375138043637 0.245465760456751 no 2541 0.246238289086402 836 45596039 SGTC_264 promethazine 12.5 mM -0.686619734936316 0.245383094770223 no 2542 0.24616119445706 854 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3 SGTC_944 3370-0224 231 µM -0.686705531942064 0.245354101755494 no 2543 0.246134155118525 816 4580514 SGTC_173 1273-0061 2.693 µM -0.687385256251803 0.245124470519581 no 2544 0.245919993049782 828 2847414 YPL266W DIM1 SGTC_2864 9034755 47.6 µM -0.687893325703547 0.244952904952391 no 2545 0.24575997994478 819 4930451 SGTC_3156 9099931 49.47 µM -0.688930527041443 0.244602862104981 no 2546 0.245433493870398 841 18111053 SGTC_2152 5568786 200 µM -0.689737066971122 0.24433085098887 no 2547 0.245179775641325 839 5399883 SGTC_3326 9140064 16.379 µM -0.690351562686003 0.244123717575947 no 2548 0.244986564645189 847 1868434 SGTC_2414 st077232 92.9 µM -0.692532111907664 0.243389465732423 no 2549 0.244301613498642 820 729801 SGTC_1178 0988-0033 191 µM -0.692955917546605 0.243246897163112 no 2550 0.244168608158436 827 5392207 SGTC_3015 9080845 49.47 µM -0.69501169716571 0.242555972226116 no 2551 0.243523985548455 824 5296973 SGTC_1294 1000-1494 117 µM -0.695083383819444 0.242531898321649 no 2552 0.243501523649033 825 712797 YDL207W GLE1 SGTC_217 ketoconazole 989 nM -0.695831545381982 0.242280726987511 no 2553 0.243267165649313 809 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4 SGTC_1193 1488-0126 41.5 µM -0.695871366255806 0.242267362354275 no 2554 0.24325469537091 828 1384710 SGTC_3295 9122362 53.5725 µM -0.695899032913636 0.242258077139473 no 2555 0.243246031502158 851 4730473 SGTC_2720 fluspirilene 36.88 µM -0.696923376241292 0.241914432796693 no 2556 0.242925373804518 844 3396 An atypical antipsychotic. SGTC_368 fentichlor 4.58 µM -0.696963872409523 0.241900852671421 no 2557 0.242912701693232 846 7329 A pesticide. SGTC_1899 st063254 59.6 µM -0.697049630413986 0.2418720956506 no 2558 0.242885867372593 823 3093813 SGTC_3227 9130768 49.47 µM -0.697512053196845 0.24171706452592 no 2559 0.242741199473702 843 17720899 SGTC_1752 st044819 83.042 µM -0.698557630173824 0.241366724995873 no 2560 0.242414265162858 827 441209 YML126C ERG13 SGTC_1309 pyrazolanthrone 13.4 µM -0.699068913329552 0.24119551078661 no 2561 0.242254482421759 851 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14 SGTC_2449 5812982 45.77 µM -0.699331578741266 0.241107577274522 no 2562 0.242172418211175 837 776185 SGTC_278 4092-0821 23.9 µM -0.699449006442105 0.241068271189 no 2563 0.24213573530378 834 877900 SGTC_1584 6-fluoro-dl-tryptophan 90 µM -0.699830011627985 0.240940762903914 no 2564 0.242016734918748 844 94937 An inhibitor of serotonin biosynthesis. SGTC_1257 0669-0121 16 µM -0.700991396965024 0.24055231679748 no 2565 0.24165419206359 840 4307855 SGTC_1740 st038286 13.222 µM -0.701391262130499 0.240418653691276 no 2566 0.241529436762547 824 716786 SGTC_3206 9114350 49.47 µM -0.702151933373835 0.240164495488625 no 2567 0.241292208923567 826 17087243 SGTC_2136 5328288 199.296 µM -0.702185878177017 0.24015315714362 no 2568 0.241281625630306 834 262395 SGTC_1914 st062367 72.6 µM -0.702416202065201 0.240076231374191 no 2569 0.241209822030023 851 978205 SGTC_2735 sertaconazole 140 nM -0.703328372427087 0.23977170800646 no 2570 0.240925566525901 869 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C SGTC_2615 purpurogallin-4-carboxylic acid 100 µM -0.703375591735965 0.23975594982323 no 2571 0.240910856749166 827 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase. SGTC_830 4076-0286 57.8 µM -0.703795878424791 0.239615715267518 no 2572 0.240779950411134 842 6866659 SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM -0.705964005696216 0.238893000873261 no 2573 0.240105260923133 843 16725076 SGTC_389 tpck 16.7 µM -0.709651921401034 0.237666429811595 no 2574 0.238960006774554 833 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.  SGTC_3158 9100007 49.47 µM -0.711191800949258 0.237155302686571 no 2575 0.238482694335793 847 19297233 SGTC_1236 0330-0013 258 µM -0.711285306865793 0.23712428503799 no 2576 0.238453727370899 845 4617066 SGTC_1117 retinoic acid 1.10837 µM -0.711848854181365 0.236937393136869 no 2577 0.23827918825045 840 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR). SGTC_2134 5324836 1.464 µM -0.717011467009186 0.235229065193452 no 2578 0.236683510593616 860 699272 SGTC_1478 0453-0656 35.7 µM -0.717966142411621 0.234913906308532 no 2579 0.236389081635291 854 5258496 SGTC_3098 9119039 49.47 µM -0.718079099579427 0.234876632161871 no 2580 0.236354258153432 844 17161528 SGTC_216 k038-0035 28.382 µM -0.718338697304945 0.234790981251903 no 2581 0.236274237667356 843 4444231 YPR107C YTH1 SGTC_1513 0337-0559 19 µM -0.718688128269226 0.234675718294302 no 2582 0.236166549822439 842 775073 SGTC_2165 5727197 32.143 µM -0.719578753664091 0.234382079024461 no 2583 0.235892198658867 845 1361712 SGTC_2472 5377652 49.4 µM -0.719738298985406 0.234329498400347 no 2584 0.235843070356235 865 1610903 SGTC_2426 5582046 32.21 µM -0.720517106621346 0.234072924056851 no 2585 0.235603335492399 835 2251934 SGTC_3273 9137859 49.47 µM -0.720894322227243 0.233948708182886 no 2586 0.235487268212344 881 2377234 SGTC_565 1418-0001 44.5 µM -0.721059272950268 0.233894401923717 no 2587 0.235436523649511 858 2862145 SGTC_1337 1486-1011 40.3 µM -0.724739266656069 0.232684665843975 no 2588 0.234306000418256 835 X1337 SGTC_1497 4476-2978 41.3 µM -0.724756326359043 0.232679065863501 no 2589 0.234300766548531 831 1528379 SGTC_467 ro 31-8220 72.8 µM -0.725840545763092 0.232323316099946 no 2590 0.233968263809854 846 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7 SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM -0.726820499975067 0.232002037934519 no 2591 0.233667961615622 848 5024745 SGTC_2312 7706453 155.7 µM -0.727198139940123 0.231878294669157 no 2592 0.23355229275527 843 976098 SGTC_2093 5331342 194.4 µM -0.727353963460777 0.231827245875479 no 2593 0.233504574199713 829 33839 SGTC_603 3794-0023 45.9 µM -0.728211106032692 0.231546552381668 no 2594 0.233242184183115 854 3802260 SGTC_1021 4476-0760 85.3 µM -0.728759078827203 0.231367203843815 no 2595 0.233074523559849 853 746768 SGTC_3310 9130229 44.1445 µM -0.729090235610299 0.231258855584441 no 2596 0.23297323354717 855 7761258 SGTC_2164 5685496 200 µM -0.730101098693688 0.230928295365198 no 2597 0.2326641949092 864 759046 SGTC_1090 efavirenz 20.7 µM -0.730529316878634 0.230788344220394 no 2598 0.232533349812517 838 64139 A non-nucleoside reverse transcriptase inhibitor. SGTC_3197 9113331 49.47 µM -0.730866815734539 0.230678075541617 no 2599 0.232430253486739 839 16610459 YLR208W | YDL195W SEC13 | SEC31 SGTC_1833 st055984 71 µM -0.731150272216433 0.230585486502124 no 2600 0.232343685218754 833 676288 SGTC_1427 4048-4900 550 nM -0.731701966851263 0.230405338939944 no 2601 0.232175247834797 849 24132586 SGTC_2149 5554786 194.827 µM -0.73174896751091 0.230389995221492 no 2602 0.232160901248521 866 745063 YPR165W RHO1 SGTC_554 4483-2211 187 µM -0.733099782409966 0.229949255776964 no 2603 0.231748786421333 857 747107 SGTC_698 k064-0052 127 µM -0.734264036049216 0.229569765885735 no 2604 0.231393916119261 877 5088751 SGTC_235 0330-0087 5 mM -0.738281229470074 0.228263054466201 no 2605 0.230171785226197 853 46494818 YHR062C RPP1 SGTC_99 0109-0120 622.8 µM -0.738403389054697 0.228223384045274 no 2606 0.230134677876897 858 759414 SGTC_2958 9077254 16.72 µM -0.739043409008014 0.228015605661995 no 2607 0.229940319320541 843 16457351 SGTC_2826 7992541 19.48 µM -0.739768846488561 0.227780225724292 no 2608 0.229720132660733 904 2985066 SGTC_2236 dapsone 200 µM -0.740806217684877 0.227443871558015 no 2609 0.22940547233446 830 2955 A bacterial DFR inhibitor. An anti-cancer agent. SGTC_1795 st049545 62.3 µM -0.741655876515086 0.227168589231318 no 2610 0.229147929870952 821 5291882 SGTC_2187 6125751 200 µM -0.744860247846248 0.226132091264858 no 2611 0.228178104331192 860 874498 SGTC_579 4491-1009 110 µM -0.745132549380129 0.226044134966361 no 2612 0.228095796876657 882 1271041 SGTC_2227 7312221 64.1025 µM -0.746446926328701 0.225619849256257 no 2613 0.22769874049207 874 887188 YOR168W | YOR169C GLN4 | YOR169C SGTC_440 fluspirilene 35.1 µM -0.746591630922153 0.225573165634569 no 2614 0.227655050881584 861 3396 An atypical antipsychotic. SGTC_1838 st055369 84.5 µM -0.746815611078013 0.22550091744474 no 2615 0.227587435481089 842 676036 SGTC_1931 st074438 57.1 µM -0.747871756193072 0.225160418396898 no 2616 0.227268757531655 876 2787313 SGTC_2099 5377090 177.372 µM -0.749296055672401 0.224701688714773 no 2617 0.226839392315743 855 2243829 SGTC_2339 9000433 200 µM -0.74998795886743 0.224479036185538 no 2618 0.226630978428983 843 2988954 SGTC_1683 st010134 710 nM -0.750638630061684 0.224269766273601 no 2619 0.226435083022614 876 3818134 SGTC_1790 st045711 43.5 µM -0.751684584867125 0.223933596862763 no 2620 0.226120381386405 814 585119 SGTC_2824 7998404 51.95 µM -0.753013307318118 0.22350695925352 no 2621 0.225720958723022 871 837851 SGTC_186 3455-3465 67.277 µM -0.753564103904081 0.223330240405104 no 2622 0.22555550275704 847 755278 SGTC_1916 st067606 49.2 µM -0.7543239295017 0.223086586760229 no 2623 0.225327368432914 830 19590279 SGTC_1622 st003707 19.4 µM -0.755622701370105 0.222670459645427 no 2624 0.224937720551403 828 10140899 SGTC_1726 st035556 14.5795 µM -0.75651662382217 0.222384303721983 no 2625 0.224669754629877 848 5919439 SGTC_1044 1222-0021 1.78 µM -0.756945969024996 0.222246939475231 no 2626 0.224541116714531 839 4306703 SGTC_879 0831-1030 162 µM -0.75699401116783 0.222231571935603 no 2627 0.224526725206893 859 1549252 SGTC_2416 tofa 880 nM -0.758271846689346 0.221823045331808 no 2628 0.224144128849208 851 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_755 1995-0008 37.3 µM -0.758494081143077 0.221752040341191 no 2629 0.224077627513824 833 689533 SGTC_2671 danthron 100 µM -0.759235565348802 0.221515226482982 no 2630 0.223855827218143 860 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin. SGTC_40 0327-0103 19.753 µM -0.763214152252152 0.220247024283058 no 2631 0.222667844999395 860 409036 SGTC_909 3448-9333 149 µM -0.764241435227896 0.21992024824268 no 2632 0.222361689210863 866 3344074 SGTC_2694 st077685 81.9 µM -0.764821221702996 0.219735942566734 no 2633 0.222189004530556 849 2838096 SGTC_405 ebelactone b 50 µM -0.765014500746385 0.21967452168769 no 2634 0.222131454954747 862 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).  SGTC_1392 3455-1037 33.9 µM -0.765027940425961 0.219670251146706 no 2635 0.22212745355504 832 981132 SGTC_3041 9091929 49.47 µM -0.766473019041451 0.219211346721475 no 2636 0.221697449974087 855 25236887 SGTC_1560 lithocholic acid 53.1 µM -0.767610542261321 0.21885049867176 no 2637 0.221359298662862 842 9903 A bile acid which acts as a detergent. SGTC_174 3553-0389 74.3 µM -0.767901960266012 0.218758109322533 no 2638 0.221272716370941 851 738071 SGTC_2600 tangeritin 87.95 µM -0.768663323566959 0.218516837395411 no 2639 0.221046601535575 875 68077 A bioactive flavone. SGTC_1512 0259-0544 12.2 µM -0.769155241300143 0.218361032832604 no 2640 0.220900578817347 855 18476 SGTC_2972 9093619 59.92 µM -0.76954470596625 0.218237723517938 no 2641 0.220785007833677 857 25236256 SGTC_390 dec-rvkr-cmk 16.7 µM -0.77285347102403 0.217191747357896 no 2642 0.219804552030015 856 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1 SGTC_2073 5212005 126 µM -0.772919669726122 0.217170850029072 no 2643 0.219784961515451 871 691789 SGTC_286 k060-0067 22.9 µM -0.773441812264901 0.217006062977859 no 2644 0.219630476385334 851 5985051 SGTC_3053 9095903 49.47 µM -0.774269485663039 0.21674499916644 no 2645 0.219385722341763 906 17174018 SGTC_2253 7938677 135.83 µM -0.774361360722908 0.216716031241896 no 2646 0.219358563330753 868 2301972 SGTC_3092 9117248 49.47 µM -0.776330307786124 0.216095766633657 no 2647 0.218776991195723 888 17141857 SGTC_237 nikkomycin 200 µM -0.776928523165717 0.215907518577917 no 2648 0.218600470929595 883 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine. SGTC_1957 st077035 62.4 µM -0.777807581362559 0.215631066615561 no 2649 0.218341228923158 876 705593 SGTC_1125 tnp00248 1.32998 µM -0.779729413281239 0.215027391732459 no 2650 0.217775081021469 873 24207736 SGTC_169 k015-0017 16.025 µM -0.779829486465725 0.214995984218254 no 2651 0.217745623913605 898 1840002 SGTC_2168 5727979 200 µM -0.780083788774555 0.214916184581458 no 2652 0.217670778933766 858 695210 SGTC_1391 3442-0225 151 µM -0.783449042110839 0.213861795007053 no 2653 0.216681733327502 852 5227075 SGTC_715 0868-0130 184 µM -0.783451790165799 0.213860935228609 no 2654 0.216680926739633 895 2876258 SGTC_3145 9085516 49.47 µM -0.783474188134118 0.213853927696233 no 2655 0.216674352725706 873 25236195 SGTC_1161 k007-0610 110 µM -0.784974686420461 0.213384779421234 no 2656 0.216234205194244 868 5843850 SGTC_1256 0570-0116 285 µM -0.78586552433416 0.213106532632072 no 2657 0.215973137019523 874 410638 SGTC_2267 7931562 200 µM -0.78798350640006 0.212445846626173 no 2658 0.21535317677277 862 934880 SGTC_549 1661-1316 519 µM -0.788154244441712 0.212392638559277 no 2659 0.215303244594408 866 2857282 SGTC_228 caffeine 993.056 µM -0.788825151587304 0.212183635377899 no 2660 0.215107103513072 842 2519 Caffeine is a phosphodiesterase inhibitor. SGTC_2734 clemastine 41.6 µM -0.789018341135081 0.212123474642892 no 2661 0.21505064339438 898 26987 Clemastine is a selective histamine H1 antagonist. SGTC_1393 3470-5649 58.2 µM -0.789854169809581 0.211863306001894 no 2662 0.214806469583256 846 4108395 SGTC_1121 fusaric acid 630.51 nM -0.790385908714358 0.211697888679446 no 2663 0.214651214538836 865 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler. SGTC_1277 0873-0036 22 µM -0.790527238522764 0.211653935462405 no 2664 0.214609960587637 870 5965735 SGTC_1152 3909-8331 15.9 µM -0.790573637200528 0.211639506754385 no 2665 0.214596417890685 860 16001939 SGTC_662 k832-1615 104 µM -0.793704737826119 0.210667151988665 no 2666 0.213683670713646 859 5878478 SGTC_2317 5986382 200 µM -0.79669792316605 0.209740081379952 no 2667 0.212813245205469 904 877883 SGTC_1263 0774-1208 64.8 µM -0.79691527801139 0.209672854241671 no 2668 0.212750118598975 876 906585 SGTC_433 pimozide 108 µM -0.798058257041714 0.209319543163229 no 2669 0.21241834188571 869 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic SGTC_1028 k015-0029 4.8 µM -0.798758002325776 0.209103414968136 no 2670 0.212215373531249 867 4588309 SGTC_3124 9127567 49.47 µM -0.80017527562566 0.208666068896648 no 2671 0.21180462627524 877 17592030 SGTC_88 0180-0332 8.668 µM -0.800363045049264 0.208608166969877 no 2672 0.211750242772921 863 3101745 SGTC_1286 0929-0070 131 µM -0.801123973209847 0.208373618688164 no 2673 0.211529939452382 872 1420408 SGTC_1608 st001473 40.5 µM -0.801192828192416 0.208352402524953 no 2674 0.211510011235399 888 7292267 SGTC_1060 3448-7350 82 µM -0.801367208063635 0.208298676865856 no 2675 0.211459546604124 879 570178 SGTC_3140 9094243 49.47 µM -0.802287907115047 0.208015149123614 no 2676 0.211193217984574 882 19291112 SGTC_697 0508-1955 564 µM -0.80279807216617 0.207858142786884 no 2677 0.211045728314366 856 6243113 SGTC_954 1189-0853 2.85 µM -0.804144013762212 0.207444257248217 no 2678 0.210656903964023 866 2828194 SGTC_1755 st041960 45.185 µM -0.80431083219127 0.20739299348055 no 2679 0.210608741663787 883 2257073 SGTC_772 k072-0172 35.3 µM -0.804341716084928 0.207383503595725 no 2680 0.21059982585565 846 5861980 SGTC_2213 7173844 200 µM -0.804727213727056 0.207265070956026 no 2681 0.210488555965984 877 892728 SGTC_1386 3228-0095 33.8 µM -0.805466577294555 0.207038035527199 no 2682 0.210275242932966 863 870181 SGTC_667 1498-1044 59 µM -0.805659235131155 0.206978900505585 no 2683 0.210219680271656 897 6739982 SGTC_3051 9093778 49.47 µM -0.806437986756407 0.206739969827818 no 2684 0.209995175618563 902 17217378 SGTC_1409 3909-8004 61.9 µM -0.807060745711132 0.206549017204811 no 2685 0.209815743184608 861 2119279 SGTC_250 brefeldin a 552.239 µM -0.807177467276962 0.206513239241169 no 2686 0.209782122813711 862 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.  SGTC_2633 5,7-dihydroxyisoflavone 100 µM -0.807218054291462 0.206500799206592 no 2687 0.209770432910102 892 5377381 SGTC_1330 1469-0054 61.8 µM -0.807436453462229 0.206433866865679 no 2688 0.209707535985713 870 7102664 SGTC_70 0141-0289 43.283 µM -0.809990978896077 0.205651941640892 no 2689 0.208972680265757 850 352408 SGTC_1023 4482-3888 16 µM -0.810482199026528 0.205501783824327 no 2690 0.208831545932287 875 3303168 SGTC_376 3970-0862 59.1 µM -0.810696435090128 0.205436315818519 no 2691 0.208770010542459 888 3135186 SGTC_31 0508-1974 57.237 µM -0.812927576734672 0.204755241812256 no 2692 0.208129791282555 848 6810525 SGTC_2979 9012552 45.46 µM -0.813036619262444 0.204721990157794 no 2693 0.208098531589996 892 17100905 SGTC_3209 9113616 49.47 µM -0.813481115550801 0.204586477775515 no 2694 0.207971134592405 866 16649353 SGTC_2497 7-hydroxyflavone 100 µM -0.813594669354628 0.204551867495203 no 2695 0.207938596343638 885 5281894 SGTC_2089 5281248 129.67 µM -0.814035022329775 0.204417684429548 no 2696 0.20781244393303 870 2737878 SGTC_2939 9044578 71.43 µM -0.814253516202992 0.204351125070728 no 2697 0.2077498665453 887 2653634 SGTC_1348 1493-0373 93.8 µM -0.815101263538335 0.204092999638481 no 2698 0.207507174224935 890 3010129 SGTC_251 melphalan 456.522 µM -0.815934044825336 0.20383962033382 no 2699 0.207268929599911 874 460612 A DNA alkylator. SGTC_1470 k295-0292 231 µM -0.818236528058831 0.203140050816446 no 2700 0.206611070551031 890 5045612 SGTC_2893 9048488 25.97 µM -0.819528408376495 0.202748163921877 no 2701 0.206242500333836 900 6467338 SGTC_1655 st012546 55.1 µM -0.821448945167437 0.202166412174877 no 2702 0.205695296929984 881 720985 YLR208W SEC13 SGTC_2206 7254556 146.969 µM -0.821941649678561 0.202017327680226 no 2703 0.205555053526679 865 4398905 SGTC_2274 7947094 46.08 µM -0.822026962084867 0.201991520196982 no 2704 0.205530775971842 871 2971028 SGTC_799 1310-0557 151 µM -0.823962802369215 0.201406448175376 no 2705 0.204980347015425 888 5354492 SGTC_2153 5569715 200 µM -0.824242077698541 0.201322126270587 no 2706 0.204901011396974 877 2054701 SGTC_2092 5303694 80.6725 µM -0.824674411484124 0.201191633004377 no 2707 0.204778231449588 875 1963699 SGTC_1621 st003705 32.4 µM -0.825869485472954 0.200831182368205 no 2708 0.204439066036993 871 24207032 SGTC_556 4058-0063 51.5 µM -0.826383807637382 0.200676175136365 no 2709 0.204293202910331 893 6615692 SGTC_1147 3809-1045 12.3 µM -0.826612102982 0.200607394144128 no 2710 0.204228477608245 862 325925 SGTC_546 peri-Naphthalide 147 µM -0.827263176826331 0.200411315888857 no 2711 0.204043955072866 858 223824 A penicillin ester. SGTC_706 4262-0057 46.9 µM -0.8280687813306 0.200168858392233 no 2712 0.203815774134307 889 883298 SGTC_636 0kpi-0074 126 µM -0.828381143076781 0.200074896378046 no 2713 0.203727341140725 884 616434 SGTC_2552 juarezic acid 87.02 µM -0.828766246931396 0.199959089201585 no 2714 0.20361834556072 874 1549512 SGTC_2242 6630449 61.2675 µM -0.82880184168982 0.199948387297058 no 2715 0.203608272965793 890 691249 YDR170C SEC7 SGTC_840 0245-0196 390 µM -0.830096300600736 0.1995594298975 no 2716 0.203242169267621 877 3827528 SGTC_339 3091-4833 71.4 µM -0.83034043297894 0.19948612437736 no 2717 0.203173166900539 877 3240077 SGTC_952 1185-0122 232 µM -0.832243166375106 0.198915347124012 no 2718 0.202635851557595 878 678600 SGTC_76 0433-0009 400.328 µM -0.83376536484228 0.198459431272606 no 2719 0.202206608076542 926 2841569 SGTC_1283 0922-0125 16.4 µM -0.83388829202588 0.198422640707704 no 2720 0.202171967696545 860 3360884 SGTC_1415 3966-0071 78.1 µM -0.834691183102445 0.198182446704462 no 2721 0.201945803598202 877 2893185 SGTC_2702 st077768 96.8 µM -0.840599469568425 0.196420319826168 no 2722 0.200286177993186 859 6484119 SGTC_1105 epirubicin 18.1 µM -0.840679877067293 0.196396404237866 no 2723 0.200263648362147 876 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_1032 k061-1018 98.7 µM -0.841309265546432 0.196209266314343 no 2724 0.200087350633225 906 4005393 SGTC_572 0960-0087 17.7 µM -0.841516838452614 0.196147571770407 no 2725 0.200029227942289 895 6796365 SGTC_3174 9107204 49.47 µM -0.843458288171453 0.195571106421284 no 2726 0.199486092335625 914 3938802 SGTC_2342 7990637 118.86 µM -0.843716100080353 0.195494633018472 no 2727 0.199414034283567 910 2033102 YER133W GLC7 SGTC_2378 9074213 121.43 µM -0.846190645753378 0.194761545491444 no 2728 0.198723199716427 881 657714 SGTC_2911 7942208 15.64 µM -0.846694340490146 0.19461253033058 no 2729 0.198582757038355 854 1243384 SGTC_999 SEC7.066 22.7 µM -0.846805865166597 0.194579545786657 no 2730 0.198551669268854 894 740511 YDR170C SEC7 SGTC_3076 9116187 49.47 µM -0.847080787314785 0.194498249329621 no 2731 0.198475046603368 880 27241210 SGTC_2034 5197015 53.07 µM -0.847118042406873 0.194487234321665 no 2732 0.198464664729447 877 780676 SGTC_273 hydroxyurea 18.1 mM -0.847502451965873 0.194373600236651 no 2733 0.19835756047704 908 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12 SGTC_1302 1159-0335 255 µM -0.848446905271821 0.19409458510885 no 2734 0.198094564910064 893 649284 SGTC_2930 9013230 14.89 µM -0.849453417571461 0.193797504921358 no 2735 0.197814520070421 853 2995857 SGTC_521 r062-0005 13.8 µM -0.850100005526139 0.193606805605081 no 2736 0.197634744279475 880 2832033 SGTC_2062 5245942 200 µM -0.850136453450361 0.193596059363383 no 2737 0.197624613325644 898 1376160 SGTC_2580 diallyl disulphide 81.36 µM -0.8503466473805 0.193534093254008 no 2738 0.197566194587284 886 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.  SGTC_317 4495-0002 170 µM -0.85087286626301 0.193379014639947 no 2739 0.19741998951556 882 15991618 SGTC_3350 9150499 3.57 µM -0.851333732313882 0.193243258042056 no 2740 0.197291995886463 893 4910996 YPR165W RHO1 SGTC_1139 k015-0024 46.9 µM -0.851383381076917 0.19322863655444 no 2741 0.197278210221972 899 2766652 SGTC_1564 D-Arginine 115 µM -0.852262792391922 0.192969763135089 no 2742 0.197034126107873 897 71070 D-isomer of arginine; arginine decarboxylase inhibitor. SGTC_1722 st034304 3.6505 µM -0.856706855193894 0.191664801240808 no 2743 0.195803456902036 905 4036148 YLR033W RSC58 SGTC_2141 5621638 7.665 µM -0.860302885120588 0.190612823307522 no 2744 0.194811051458687 883 2856238 SGTC_1181 1222-0449 220 µM -0.86076360955075 0.190478300188413 no 2745 0.194684125637776 904 658318 SGTC_442 cape 100 µM -0.861058920218935 0.190392105532479 no 2746 0.194602796424609 880 5281787 SGTC_3008 9078912 71.4286 µM -0.862865795796072 0.189865240333604 no 2747 0.194105629263054 910 16648731 SGTC_148 3253-0744 288.01 µM -0.865362223375301 0.18913878583557 no 2748 0.193420004208337 886 6893655 SGTC_2118 5526350 200 µM -0.866184323570963 0.188899931775961 no 2749 0.193194544366214 900 743594 SGTC_2459 5811157 9.22 µM -0.866636829983529 0.188768539312214 no 2750 0.193070513586866 888 2870684 YBR192W RIM2 SGTC_3210 9128157 49.47 µM -0.868384621953718 0.188261569136412 no 2751 0.192591905274021 904 17590849 SGTC_1633 st005664 67.9 µM -0.868553851457834 0.188212526527514 no 2752 0.192545602685592 915 2063822 SGTC_3049 9092223 49.47 µM -0.871060459892574 0.187487036333449 no 2753 0.191860571025561 891 8623917 SGTC_3219 9131112 49.47 µM -0.871088631875905 0.187478892321749 no 2754 0.191852880385448 874 17612988 YMR079W SEC14 SGTC_792 4534-1957 155 µM -0.87228740393953 0.187132551573223 no 2755 0.191525803756188 884 1717904 SGTC_3033 9090887 49.47 µM -0.873388845906964 0.186814679819771 no 2756 0.191225584296828 901 19325384 SGTC_893 0958-0369 48.9 µM -0.875517589925923 0.186201280555353 no 2757 0.190646171813991 897 6819948 SGTC_2150 5556613 200 µM -0.878205241356304 0.185428616746409 no 2758 0.189916174070411 917 743190 SGTC_1057 3448-5381 134 µM -0.879585478672665 0.185032591634282 no 2759 0.189541954147581 864 5497911 SGTC_569 4130-2812 160 µM -0.879851138589247 0.184956427409627 no 2760 0.189469978610641 895 743552 SGTC_3341 9147222 25.867 µM -0.880186412585618 0.184860332763657 no 2761 0.189379166464913 888 1939759 SGTC_2234 tolnaftate 200 µM -0.88039158734271 0.184801541853251 no 2762 0.189323606149532 913 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7 SGTC_2905 7799065 20.05 µM -0.880463383313388 0.184780972133613 no 2763 0.189304166523844 881 1296806 SGTC_304 1310-0298 97 µM -0.880607885907636 0.18473957610513 no 2764 0.189265044427731 901 1550234 SGTC_622 1348-1566 26.3 µM -0.88103746889089 0.184616546415907 no 2765 0.189148770122218 897 7340407 SGTC_3234 9132280 49.47 µM -0.88146000400269 0.184495584903431 no 2766 0.189034446371093 889 17612295 SGTC_2271 7849410 118.62 µM -0.888977398291302 0.182351784514863 no 2767 0.187007613411063 909 972430 SGTC_398 bronopol 33.3 µM -0.88936231381088 0.1822424353315 no 2768 0.186904195948687 883 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them. SGTC_3179 9107801 49.47 µM -0.889765888129423 0.1821278294592 no 2769 0.186795803331885 874 4818259 SGTC_2761 levamisole 97.89 µM -0.890551991021716 0.181904723605023 no 2770 0.186584782325957 883 26879 An alkaline phosphatase inhibitor. SGTC_1225 1216-0074 20.6 µM -0.892423646670559 0.1813742125967 no 2771 0.186082950596552 900 4241466 SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM -0.893070488228046 0.181191094209415 no 2772 0.185909712976812 924 91467 include heat shock SGTC_1985 st071382 65.5 µM -0.893866287444503 0.180965965405954 no 2773 0.185696718657633 931 6123237 SGTC_2710 st078562 53.7235 µM -0.894022173909973 0.180921886212118 no 2774 0.185655013647042 909 17250908 SGTC_573 3702-0553 84.7 µM -0.894880860822105 0.18067920047431 no 2775 0.185425389442753 896 1222756 SGTC_364 0083-0097 67.7 µM -0.896275478167881 0.180285483004056 no 2776 0.185052826247752 931 5207356 SGTC_461 N-acetylfarnesylcysteine 136 µM -0.899392618977415 0.17940742451912 no 2777 0.18422178464893 948 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ). SGTC_1826 st055655 41.6 µM -0.901199056943826 0.178899806824515 no 2778 0.18374124614704 901 676168 SGTC_818 4072-2707 53.5 µM -0.901244729445735 0.178886984360502 no 2779 0.183729106734131 907 882871 SGTC_1460 k062-0059 9.15 µM -0.901286781362281 0.178875178880101 no 2780 0.183717930087837 882 1373085 SGTC_2982 9019404 25.97 µM -0.90134861290752 0.178857821439483 no 2781 0.183701497139798 889 22333232 SGTC_1011 4112-3381 17.4 µM -0.903113861405588 0.178362725567679 no 2782 0.183232734007922 902 2877139 SGTC_2245 6637752 200 µM -0.90387672277015 0.17814903477189 no 2783 0.183030386631057 913 681890 SGTC_1801 st050089 28.441 µM -0.90562675600374 0.177659429941144 no 2784 0.182566721010984 900 5008493 YIL048W | YNL267W NEO1 | PIK1 SGTC_771 0250-0039 27.3 µM -0.906131638417793 0.177518337513693 no 2785 0.182433090519648 907 3005115 SGTC_696 1560-0013 611 µM -0.908181378251142 0.176946252082189 no 2786 0.181891200468062 895 1650269 SGTC_1669 st015249 58.4 µM -0.910463339650211 0.176310725436999 no 2787 0.181289103524675 920 722793 SGTC_2510 benzyl isothiocyanate 8.31 µM -0.910676167470326 0.176251526576301 no 2788 0.181233012471999 901 2346 DNA damaging agent; causes G2/M arrest. SGTC_2562 3',7'-dimethoxyflavone 64.92 µM -0.913165975607709 0.175559911628395 no 2789 0.180577627808242 891 688664 SGTC_555 4296-0685 37 µM -0.916323796273465 0.174685214887076 no 2790 0.179748545280023 910 2908540 YHR072W ERG7 SGTC_3217 9129673 49.47 µM -0.919750098328473 0.173739285947759 no 2791 0.17885168300377 914 17248312 SGTC_804 1595-0054 20.9 µM -0.92025248732668 0.173600861475512 no 2792 0.178720415796981 913 761523 Stimulates phospholipase C. SGTC_2596 sinensetin 100 µM -0.920544365049509 0.173520471929496 no 2793 0.178644180101937 926 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets. SGTC_2528 xanthyletin 44.79 µM -0.920722944119122 0.17347129900867 no 2794 0.178597547039973 931 65188 An natural product with antifungal activity of unknown mechanism. SGTC_744 1594-0068 283 µM -0.921061227648903 0.173378174731099 no 2795 0.17850923073556 911 668392 SGTC_1999 st074831 12.5 µM -0.921348236156826 0.173299190641574 no 2796 0.178434322469412 914 17112523 SGTC_2723 salbutamol 83.58 µM -0.921535135026196 0.173247768816113 no 2797 0.178385553134048 897 9884233 β2-adrenoceptor agonist SGTC_1704 st028805 70.8 µM -0.921990121147871 0.173122628278359 no 2798 0.17826686430209 904 2876101 SGTC_951 1171-0579 82.7 µM -0.92421360385423 0.172511904394553 no 2799 0.177687557080371 899 1616050 YPR165W | YDR526C RHO1 | YDR526C SGTC_2695 st077686 51.995 µM -0.925058655241308 0.172280154934223 no 2800 0.177467698853554 922 2876092 SGTC_1967 st070177 51.4 µM -0.925462541115201 0.17216946223365 no 2801 0.177362679964867 932 5729214 SGTC_2197 6588183 93.1375 µM -0.926193736398344 0.171969179582202 no 2802 0.177172653536029 887 884136 SGTC_1108 betulinic acid 729.144 nM -0.929299199857353 0.17112021631432 no 2803 0.176367024888183 886 64945 Apoptosis-inducing agent of unknown mechanism. SGTC_309 k408-0051 1.48 µM -0.929558288783191 0.171049508623336 no 2804 0.17629991617315 896 3640463 SGTC_1543 azetidyl-2-carboxylic acid 198 µM -0.9296368896026 0.1710280614502 no 2805 0.176279560335111 913 16486 A toxic proline analog. SGTC_338 4055-0136 114 µM -0.930338734079044 0.170836631055706 no 2806 0.176097864394337 917 2900563 SGTC_4 0960-0234 25.671 µM -0.931729197496077 0.170457782650027 no 2807 0.175738246631508 885 6821112 SGTC_2005 4024620 188 µM -0.934835466175195 0.169613387762067 no 2808 0.174936549445746 917 236743 SGTC_374 0880-0231 82.3 µM -0.934876768917163 0.169602178307243 no 2809 0.174925905275199 904 6833587 SGTC_2071 5230951 39.92 µM -0.938502971473789 0.168619889271914 no 2810 0.173992995310635 913 1799272 SGTC_3056 9094900 49.47 µM -0.939987356392425 0.16821884655838 no 2811 0.173612023080295 916 25236784 SGTC_358 0075-0058 9.45 µM -0.940862881043275 0.167982590203837 no 2812 0.173387565874536 952 1069125 SGTC_1233 0325-0408 14.2 µM -0.942092724429625 0.167651083422232 no 2813 0.173072584551474 910 12874 SGTC_282 k297-0036 65.7 µM -0.942828812201 0.167452871171746 no 2814 0.172884235917679 933 5061378 SGTC_2719 novobiocin 32.65 µM -0.942855937517327 0.167445569806278 no 2815 0.172877297643484 932 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication. SGTC_1062 mesoridazine 14.2 µM -0.943534378496518 0.167263019472813 no 2816 0.172703819711186 892 4078 A neuroleptic. SGTC_10 0279-0212 42.575 µM -0.943931479301599 0.167156229798157 no 2817 0.172602332203789 920 39851 YBR002C RER2 SGTC_1856 st057054 55.7 µM -0.945553172802528 0.166720574976663 no 2818 0.172188268979909 913 1266018 SGTC_1624 st003710 6.25 µM -0.950177728779913 0.165482253135074 no 2819 0.171010976514293 936 24207033 SGTC_3264 9137442 49.47 µM -0.95084587179145 0.165303836979729 no 2820 0.170841311266776 903 17015726 SGTC_132 0417-1715 25.805 µM -0.952309520369713 0.164913429861552 no 2821 0.170470015475484 924 6769098 SGTC_2100 5377183 190 µM -0.952358827513251 0.164900288298236 no 2822 0.170457516330418 893 2844202 SGTC_1760 st045453 10.4495 µM -0.953766636595533 0.164525358776909 no 2823 0.170100890511381 919 3323419 YIL048W NEO1 SGTC_2243 6634756 200 µM -0.954900968806559 0.164223664213019 no 2824 0.169813889897431 909 885676 SGTC_1481 3346-2004 36 µM -0.955766414969812 0.163993725810953 no 2825 0.169595129861602 928 2770522 SGTC_2703 st077852 53.4 µM -0.957880888046568 0.16343281536631 no 2826 0.169061412387002 921 6281836 SGTC_1077 5-fluorocytosine 377 nM -0.958182182550513 0.163352991927335 no 2827 0.168985450064561 931 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_1978 st071761 42 µM -0.959281280754017 0.163062017170308 no 2828 0.168708531491294 908 5147680 SGTC_1394 3474-0001 65.7 µM -0.959454394716544 0.163016217787929 no 2829 0.16866494190553 903 5017666 YIL048W NEO1 SGTC_2006 4011487 200 µM -0.959489302949845 0.163006983407874 no 2830 0.168656152992317 913 45595294 SGTC_3104 9120930 49.47 µM -0.959721693074518 0.162945517215787 no 2831 0.168597651185356 909 17014836 SGTC_736 0958-0254 92.6 µM -0.962010786673498 0.16234086714974 no 2832 0.168022092788535 930 6812352 SGTC_2020 4017018 200 µM -0.963204023139738 0.162026260864193 no 2833 0.167722573275239 948 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope. SGTC_2074 5212007 75.395 µM -0.963946374378623 0.161830734568239 no 2834 0.167536406040314 883 758611 SGTC_1526 st051518 75 µM -0.965002773171236 0.16155275713701 no 2835 0.167271711389825 925 673993 SGTC_2889 9059656 51.95 µM -0.966396793928199 0.16118641564237 no 2836 0.166922833872706 922 3949838 SGTC_2978 9011784 42.97 µM -0.967478418390338 0.160902543988741 no 2837 0.166652462459503 894 2994934 SGTC_650 1328-0195 38 µM -0.967702085482932 0.160843883447361 no 2838 0.166596588145727 927 2780821 SGTC_2621 lithochol-11-enic acid 100 µM -0.968925175577555 0.160523353997226 no 2839 0.166291261669113 944 6708711 SGTC_3346 9158254 43.5805 µM -0.970250706488169 0.16017644985878 no 2840 0.165960770671532 924 17639500 SGTC_115 0527-0192 112.043 µM -0.970446300020007 0.160125302682241 no 2841 0.16591203983387 937 4233931 SGTC_2373 9071805 200 µM -0.970610033237342 0.160082495102659 no 2842 0.165871253895047 946 10149009 SGTC_3169 9102970 49.47 µM -0.971469358160005 0.159857949770257 no 2843 0.165657302357979 944 17027839 SGTC_172 1112-0046 2.638 µM -0.973358692548954 0.159364983306647 no 2844 0.165187530667748 955 2802135 YIL048W NEO1 SGTC_1208 2323-2347 50.3 µM -0.973817825691599 0.159245336458243 no 2845 0.165073500316006 924 5412760 SGTC_2044 5102272 200 µM -0.97440507231806 0.159092389908016 no 2846 0.164927725979238 922 592666 SGTC_2265 7929201 200 µM -0.974633054203561 0.159033038678621 no 2847 0.164871155688963 915 1265108 SGTC_214 4373-3496 70 µM -0.974713826662089 0.159012014415481 no 2848 0.164851116228423 934 3779166 SGTC_1396 3511-0007 98.6 µM -0.975960905355815 0.158687643429513 no 2849 0.164541919101409 895 X1396 SGTC_2124 5246320 200 µM -0.977707857157243 0.158233983149655 no 2850 0.164109417306178 915 579342 SGTC_598 3937-0236 20.2 µM -0.978062240895091 0.158142058317524 no 2851 0.164021770759354 940 1379313 SGTC_2158 5657123 3.6195 µM -0.978662259989507 0.157986497202938 no 2852 0.163873442676209 954 2858827 SGTC_2721 ifenprodil 61.44 µM -0.980643966110137 0.157473433617479 no 2853 0.163384172532042 929 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor. SGTC_2990 9074105 71.4286 µM -0.9808399046997 0.157422764682569 no 2854 0.163335848191129 930 6502001 SGTC_3100 9120536 49.47 µM -0.984021329051422 0.15660156072494 no 2855 0.162552512930802 909 16421196 SGTC_1078 idebenone 36.1 µM -0.985611638340574 0.156192121837913 no 2856 0.16216186234886 943 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen. SGTC_2598 perillyl alcohol 100 µM -0.987504489145696 0.155705711149503 no 2857 0.161697691640573 937 10819 An apoptosis inducer. SGTC_176 1486-1328 72.834 µM -0.988743675746674 0.155387815849954 no 2858 0.16139428397246 919 22310231 SGTC_3274 9138298 49.47 µM -0.988950560938012 0.1553347842124 no 2859 0.161343665520998 953 17015756 SGTC_501 nsc-95397 161 µM -0.988985804950735 0.155325751176601 no 2860 0.161335043425983 920 262093 SGTC_319 1348-1596 45.5 µM -0.989658301607264 0.155153456790246 no 2861 0.16117058142547 924 5380505 SGTC_465 cgp-37157 41 µM -0.98972823991572 0.155135545764218 no 2862 0.161153483987476 890 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange. SGTC_1875 nocodazole 6 µM -0.992102318227413 0.154528359898495 no 2863 0.160573807899078 921 4122 A microtubule depolymerizer. YJL014W CCT3 SGTC_28 pentachloropyridine N-oxide 1.606 µM -0.993319011838726 0.154217792258077 no 2864 0.160277257691693 922 140250 A respiratory chain inhibitor. SGTC_3291 9121177 71.43 µM -0.993835667281676 0.154086038108899 no 2865 0.160151439278857 930 17015612 SGTC_2260 7964312 200 µM -0.997811608981226 0.153074611117207 no 2866 0.159185359896923 935 231951 SGTC_1887 st057648 70.8 µM -0.997833983054076 0.153068931929106 no 2867 0.159179934239223 949 688672 SGTC_2257 7960413 200 µM -0.999563164113457 0.152630438159508 no 2868 0.158760978514523 907 2974689 YIL048W NEO1 SGTC_2649 anisomycin 9.56 µM -1.00042791614835 0.152411463207357 no 2869 0.158551732904905 937 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_3023 9089636 49.47 µM -1.00234738268119 0.151926155866959 no 2870 0.158087922696956 951 17249241 SGTC_2568 diosmetin 100 µM -1.00338327439629 0.151664673682272 no 2871 0.15783798543637 932 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.  SGTC_2280 7785178 200 µM -1.00466615051305 0.151341261958418 no 2872 0.157528816311075 916 2954328 SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM -1.00625779400811 0.150940648284505 no 2873 0.157145788735613 899 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_571 k831-0106 44.2 µM -1.00653258760409 0.150871554766651 no 2874 0.157079721953374 912 4783639 SGTC_3347 9188721 44.724 µM -1.00731273505009 0.150675510898827 no 2875 0.156892255900186 933 44118411 YKL104C | YBL026W GFA1 | LSM2 SGTC_2487 5918373 44.05 µM -1.012841644071 0.149291009662271 no 2876 0.155567902897279 921 2876279 SGTC_2924 9010168 62.78 µM -1.01756823488571 0.14811417334372 no 2877 0.154441594763878 942 2993929 SGTC_261 5-fluorouridine 15.376 µM -1.01855169335993 0.147870092176823 no 2878 0.154207923835299 937 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_221 trifluoperazine 10.304 µM -1.0190211950011 0.147753663203396 no 2879 0.154096452179342 945 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1 SGTC_480 am 92016 50 µM -1.0199175295159 0.147531556948737 no 2880 0.153883787582156 957 2129 K+ channel blocker. SGTC_1660 st012960 28.1 µM -1.02164550919946 0.147104005605853 no 2881 0.15347435501892 930 24207266 SGTC_1928 4'-methoxychalcone 40.3 µM -1.0246531967653 0.146361801364714 no 2882 0.152763427133894 933 641818 SGTC_2283 7944793 200 µM -1.0248027967383 0.146324950475389 no 2883 0.152728123262884 905 2970533 SGTC_1009 4106-0057 9.87 µM -1.02550049786643 0.146153168380141 no 2884 0.15256354530835 922 2928005 SGTC_688 0527-0193 473 µM -1.02616262254734 0.145990270939911 no 2885 0.152407468202914 957 4007154 SGTC_1545 lovastatin 49.4 µM -1.02635792903384 0.145942244495349 no 2886 0.152361450487485 934 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12 SGTC_1675 st018485 24.5 µM -1.02823572822975 0.145481029857715 no 2887 0.151919477919185 946 3323024 SGTC_2385 9074692 200 µM -1.02996258005779 0.145057756216673 no 2888 0.151513785933083 926 17046906 SGTC_1959 st077091 55.8 µM -1.03045611456036 0.1449369370052 no 2889 0.15139797157032 918 821356 YKL052C ASK1 SGTC_2190 6049624 200 µM -1.03348884330367 0.144196000426204 no 2890 0.150687594466174 915 2265554 SGTC_582 0987-0078 156 µM -1.03421042545424 0.144020084907679 no 2891 0.150518900677927 950 1625765 SGTC_2357 9067248 200 µM -1.03471432348381 0.14389732476626 no 2892 0.150401172405759 977 9150235 SGTC_260 nsc-65238 3.989 µM -1.03861980730308 0.142948260790375 no 2893 0.149490795073865 943 3246252 SGTC_2964 9083345 53.42 µM -1.03915686458809 0.142818083145698 no 2894 0.149365894033675 912 17741579 SGTC_3355 9151058 44.0485 µM -1.03998070028612 0.142618548886519 no 2895 0.149174433641701 926 17015728 SGTC_2304 7443016 91.4 µM -1.04206841721918 0.142113745121229 no 2896 0.148689979978974 939 939854 SGTC_2875 9039966 71.43 µM -1.04302852858619 0.141881999490971 no 2897 0.148467540047112 954 6463691 SGTC_629 3448-6466 76.7 µM -1.04339293627762 0.141794108089391 no 2898 0.148383171858075 945 573744 SGTC_3280 9140961 49.47 µM -1.04394219355574 0.14166170254758 no 2899 0.148256067630801 957 4901226 SGTC_2759 disulfiram 3.38 µM -1.04720956490261 0.140875791888959 no 2900 0.147501467395154 905 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_985 1493-0307 8.71 µM -1.04839916748901 0.140590389104646 no 2901 0.147227368479584 959 3278274 SGTC_1252 0493-0875 34.8 µM -1.04972153117724 0.140273595925943 no 2902 0.146923080743818 928 3960963 SGTC_133 0724-0033 378.92 µM -1.05042804313511 0.140104538648848 no 2903 0.146760679015972 930 280309 SGTC_677 0929-0063 136 µM -1.05186200222037 0.13976184036616 no 2904 0.146431433725971 975 1539583 SGTC_1274 0865-0114 173 µM -1.0543200642911 0.139175720897197 no 2905 0.14586820282258 928 870624 SGTC_2838 9002687 71.43 µM -1.05497037117961 0.139020936887532 no 2906 0.145719437865857 947 6457060 SGTC_638 3970-0837 4.09 µM -1.05616656778296 0.138736528049589 no 2907 0.145446060978797 920 4118451 YLR208W SEC13 SGTC_2679 rapamycin 1 nM -1.05751134530963 0.13841726597711 no 2908 0.145139139772927 899 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2 SGTC_53 0973-0023 39.979 µM -1.05922731452773 0.138010607331094 no 2909 0.144748134125279 942 674768 SGTC_958 1222-0007 33 µM -1.05923296459658 0.138009269697912 no 2910 0.144746847857341 937 7312461 SGTC_1776 st049249 45.9 µM -1.05949096571984 0.137948198294194 no 2911 0.144688120743872 967 1822314 SGTC_2675 theaflavin digallate 100 µM -1.05962186087527 0.137917221173177 no 2912 0.144658332070504 963 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative. SGTC_2261 9010538 184.68 µM -1.05990190853928 0.137850962156754 no 2913 0.14459461365244 955 6457250 SGTC_2677 mitomycin C 100 µM -1.06046822752916 0.13771703798515 no 2914 0.144465818550438 975 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_691 1548-0686 185 µM -1.06095654214755 0.137601631741608 no 2915 0.144354825677189 924 46495133 SGTC_729 4092-0585 94.1 µM -1.06124820542384 0.137532732754368 no 2916 0.144288558658557 934 2169061 SGTC_625 k213-0058 121 µM -1.06207237202722 0.1373381689671 no 2917 0.144101415685953 947 3655420 SGTC_1555 citronellol 128 µM -1.0623852587476 0.137264353992839 no 2918 0.144030411584059 946 8842 A terpine precursor. SGTC_2722 naftopidil 47.16 µM -1.06314961002115 0.137084145286165 no 2919 0.143857054831313 946 4418 An a1-adrenergic receptor antagonist or alpha blocker.  SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM -1.06345400006314 0.137012425221968 no 2920 0.143788057625045 949 7104 SGTC_708 3448-5400 146 µM -1.06881522198071 0.13575342174824 no 2921 0.142576469444563 951 3462195 SGTC_1360 1598-0022 39.8 µM -1.06892838831951 0.135726931983097 no 2922 0.142550969487711 941 761525 SGTC_2244 6635614 200 µM -1.06906256250046 0.135695529329101 no 2923 0.142520739795794 965 836499 SGTC_3000 9075062 71.4286 µM -1.0700945286954 0.135454170235224 no 2924 0.142288380809784 904 17057871 SGTC_2372 9071633 200 µM -1.07091441060399 0.13526262383366 no 2925 0.142103957838388 954 21321366 SGTC_289 k017-0060 526 µM -1.07311037261118 0.134750503244968 no 2926 0.141610798800316 951 5512909 SGTC_660 4031-1742 102 µM -1.07393306502059 0.134558986071605 no 2927 0.141426341238752 906 6738706 SGTC_651 3253-0966 34.4 µM -1.07592025757103 0.134097152223929 no 2928 0.140981460620869 944 781462 SGTC_2937 9044753 11.33 µM -1.07696969483032 0.133853697467261 no 2929 0.140746902375856 909 6465530 YGL099W LSG1 SGTC_1230 0170-0365 3.77 µM -1.07889480832463 0.133407888260334 no 2930 0.140317311748688 916 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1 SGTC_1026 k007-1105 30.6 µM -1.08089496161799 0.132945784649692 no 2931 0.139871920050127 939 7066794 SGTC_2170 morpholine 200 µM -1.08158419526088 0.132786803774098 no 2932 0.139718665191994 950 121171 Reacts with secondary amines. SGTC_3325 9138760 55.175 µM -1.08336688012654 0.132376211309253 no 2933 0.139322805156503 925 43844959 SGTC_340 k038-0059 454 µM -1.08342495600383 0.132362849860155 no 2934 0.13930992177154 937 23733424 SGTC_2437 5741531 144.16 µM -1.08364889593607 0.132311336964468 no 2935 0.139260251172549 910 2262990 SGTC_1840 st055363 71 µM -1.08471558145156 0.132066157008692 no 2936 0.139023822307065 975 676033 SGTC_1600 coumarin 106 71.1 µM -1.08618467283618 0.131728996357709 no 2937 0.138698648484984 952 100336 A hepatotoxic, DNA x-linker. SGTC_1326 1431-2094 10.8 µM -1.08669647052579 0.13161167695123 no 2938 0.138585487175273 959 616278 SGTC_1259 0671-0132 43 µM -1.09091602033021 0.130647177381367 no 2939 0.137654918568646 945 X1259 SGTC_2950 9072895 21.46 µM -1.09202355002649 0.130394831304794 no 2940 0.137411375050473 920 17332245 SGTC_2102 5377816 72.7585 µM -1.09273931495706 0.130231926675774 no 2941 0.137254136406327 946 1379702 SGTC_1087 pterostilbene 9.05 µM -1.09400507794842 0.129944189964354 no 2942 0.136976375561117 966 5281727 Similar to reservatol, lowers cholesterol. SGTC_3267 9137951 49.47 µM -1.09647706778186 0.129383520216907 no 2943 0.136435026806282 997 16643986 SGTC_2757 clomiphene 4.22 µM -1.09693342597989 0.129280197616098 no 2944 0.136335247751195 962 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined. SGTC_1295 1013-0063 9.78 µM -1.09910971031833 0.128788258753962 no 2945 0.135860107467276 965 6826038 SGTC_6 0844-0013 19.835 µM -1.1005554491095 0.128462175064475 no 2946 0.135545092114249 976 1584900 SGTC_3301 9125354 19.7965 µM -1.10072500054247 0.128423970635083 no 2947 0.135508180976741 931 41905162 SGTC_2482 5981709 142.65 µM -1.10106612466647 0.128347130232829 no 2948 0.135433939546086 966 877755 SGTC_2395 5646831 180.19 µM -1.10234870112839 0.128058507298704 no 2949 0.135155052160532 981 6808628 SGTC_1582 3',3',6'-trihydroxyflavone 74 µM -1.10451285991751 0.127572521467353 no 2950 0.134685364096685 945 688803 SGTC_2105 5350118 200 µM -1.10553099320073 0.127344332455798 no 2951 0.134464786209509 955 2133313 SGTC_3181 9108277 49.47 µM -1.10719212448715 0.12697264134306 no 2952 0.134105435905399 968 17097298 SGTC_1468 k284-1086 134 µM -1.10741445395007 0.126922950742579 no 2953 0.134057389778379 948 15996457 SGTC_362 0310-0100 9.03 µM -1.10883070602275 0.12660673637833 no 2954 0.133751610681526 965 790235 SGTC_1488 4013-0813 75.9 µM -1.11107458459604 0.126106857441096 no 2955 0.13326812329268 928 2910057 SGTC_538 2922-0838 53.3 µM -1.11214043886687 0.12586989491438 no 2956 0.133038885986913 976 777039 SGTC_860 0443-0016 25.1 µM -1.11457898674589 0.125328921310535 no 2957 0.132515439600842 943 5337942 SGTC_1154 4088-0362 150 µM -1.11646167278268 0.124912373317393 no 2958 0.132112283643124 956 6618304 SGTC_2775 cyproheptadine 69.59 µM -1.11853237555981 0.12445534429128 no 2959 0.131669843561627 956 2913 A selective serotonin reuptake inhibitor. SGTC_419 nsc-638432 893 µM -1.12238015536837 0.123609200723041 no 2960 0.130850419204041 958 368090 SGTC_400 oxethazaine 37.5 µM -1.13189927220104 0.121533241431664 no 2961 0.128838392357244 955 4621 A local anesthetic. SGTC_2872 9044037 25.97 µM -1.13434321058017 0.121004236195498 no 2962 0.128325305178157 962 6465195 SGTC_2276 7947513 42.08 µM -1.13478848073508 0.120908029517258 no 2963 0.128231976930115 971 2105100 SGTC_980 1473-0395 201 µM -1.13603013137581 0.120640038360409 no 2964 0.127971977022809 958 768876 SGTC_83 0170-0301 39.027 µM -1.13812981448725 0.120187806189901 no 2965 0.127533140130115 975 3089716 SGTC_37 0566-0070 1.56 µM -1.13815384520036 0.120182637350152 no 2966 0.12752812373897 950 1626686 SGTC_1559 coumarin 343 70.1 µM -1.13865823006866 0.120074183806587 no 2967 0.127422865481959 956 108770 A hepatotoxic, DNA x-linker. SGTC_1228 0124-0032 52.5 µM -1.1402346404976 0.119735666543657 no 2968 0.127094279656272 952 X1228 SGTC_2038 4100038 30.985 µM -1.14225944068184 0.119301850512886 no 2969 0.126673097500202 936 3596803 SGTC_1771 st048882 4.1505 µM -1.14421741211254 0.118883408696835 no 2970 0.12626674187597 969 4580403 SGTC_1120 ficusin 1.78878 µM -1.14479027460813 0.118761177394759 no 2971 0.126148022483457 971 6199 A DNA cross-linker. SGTC_1217 1183-1422 255 µM -1.1459794933153 0.118507718069284 no 2972 0.125901818586793 951 2849664 SGTC_750 4073-0104 132 µM -1.14621267686805 0.118458064297764 no 2973 0.125853581928724 908 22330957 SGTC_2794 7785382 27.27 µM -1.14686895682651 0.118318395920378 no 2974 0.125717892180865 947 2205081 SGTC_3 0833-0587 95.581 µM -1.14955491127017 0.117747989101824 no 2975 0.125163619008553 963 5382644 SGTC_1501 4491-0275 38.4 µM -1.15100185153902 0.117441515255594 no 2976 0.1248657369105 961 5104718 SGTC_2050 5263056 171 µM -1.15118240737692 0.117403311719665 no 2977 0.124828600607706 947 763468 YGL055W OLE1 SGTC_2333 9017922 200 µM -1.15199882636517 0.117230676727367 no 2978 0.124660777802711 949 3163164 SGTC_574 1315-0397 40 µM -1.15462016885364 0.116677599384019 no 2979 0.124123001850148 977 6794277 SGTC_845 0330-0138 4.51 µM -1.15873984474661 0.115812131638047 no 2980 0.123281122125522 955 9039800 SGTC_530 4358-1714 28 µM -1.15984002241174 0.11558177792367 no 2981 0.12305697293291 943 1564641 SGTC_1288 0973-0013 65.5 µM -1.16108761262569 0.115320953242725 no 2982 0.12280313589091 973 4315430 SGTC_703 3875-0075 71.8 µM -1.16109829634543 0.115318721482624 no 2983 0.122800963748198 1001 2850814 SGTC_52 0329-0193 875 nM -1.16180252765154 0.115171679805904 no 2984 0.122657843552546 977 3739292 SGTC_1516 st013856 110 µM -1.16346426084936 0.114825242703478 no 2985 0.122320595158122 978 5281404 A mutagen and neurotoxin. SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM -1.16348741498442 0.114820420786267 no 2986 0.122315900633579 978 364106 SGTC_2852 9023854 51.95 µM -1.16564157781103 0.114372439959291 no 2987 0.121879695008178 961 19798528 SGTC_205 1486-1330 71.903 µM -1.16653526073898 0.114186954881191 no 2988 0.121699050433751 975 4118834 SGTC_3317 9138495 8.753 µM -1.16693754829816 0.114103529527325 no 2989 0.121617795486821 966 17020139 SGTC_966 1300-0360 30.2 µM -1.16711106128941 0.114067560256495 no 2990 0.121582760714003 928 70588 SGTC_724 3910-0327 137 µM -1.16721305019421 0.114046421709774 no 2991 0.121562170995165 974 2885483 SGTC_2247 cerulenin 830 nM -1.16818584234803 0.113844937937942 no 2992 0.121365904986071 945 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12 SGTC_1175 0741-0056 27.6 µM -1.17216869193748 0.11302265964562 no 2993 0.120564667722856 968 765927 SGTC_541 4513-1321 94 µM -1.17241509767328 0.112971927594518 no 2994 0.120515220453599 944 747515 SGTC_1961 st076550 68.7 µM -1.17376182815513 0.112694938750309 no 2995 0.120245218743417 969 1579337 SGTC_2349 9023730 187.07 µM -1.17380478185916 0.112686112233227 no 2996 0.120236614110852 986 4126287 SGTC_3250 9135583 49.47 µM -1.17392804886807 0.112660784950314 no 2997 0.120211923251876 977 7699353 SGTC_101 0490-5701 117.494 µM -1.17420510166476 0.112603874624706 no 2998 0.120156441543023 944 4661669 SGTC_2415 st077333 57.7 µM -1.17436770666892 0.112570482959468 no 2999 0.120123887187815 932 2766255 SGTC_1102 cgs 12066b 26.1 µM -1.17451493439492 0.11254025518856 no 3000 0.12009441680449 956 6438352 A 5-HT1B full agonist. SGTC_1384 3089-0840 101 µM -1.17519645623113 0.112400405410462 no 3001 0.119958063845053 961 1069836 SGTC_1349 flufenamic acid 69 µM -1.17816129930386 0.111793458163179 no 3002 0.119366153960993 968 3371 A non-steroidal anti-inflammatory. SGTC_2684 capsaicin 100 µM -1.17983106445776 0.111452666168201 no 3003 0.119033705852654 965 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_637 1181-0519 7.26 µM -1.18150103636155 0.111112576251572 no 3004 0.118701870993667 962 6252091 YGR060W ERG25 SGTC_2067 5224629 34.075 µM -1.18247587149955 0.110914394845027 no 3005 0.118508466948789 970 2835000 SGTC_2656 pseudo-anisatin 100 µM -1.1825717597905 0.110894914696196 no 3006 0.118489455068585 1012 6708809 A neurotoxin. SGTC_853 0419-0306 21 µM -1.18344435101716 0.110717756391039 no 3007 0.118316544475785 962 762713 SGTC_1657 st012939 43.4 µM -1.18388881287417 0.110627597283398 no 3008 0.118228539582209 949 24207257 SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM -1.1862069336428 0.110158219254007 no 3009 0.117770294365144 952 6708514 SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM -1.18767927711489 0.10986083880177 no 3010 0.117479895566772 972 66535 A nucleotide analog. SGTC_2023 5144124 124 µM -1.1880248003819 0.109791134378164 no 3011 0.1174118195333 958 2830192 SGTC_1003 4049-0218 100 µM -1.19016263267994 0.109360562764341 no 3012 0.116991238460377 971 295161 SGTC_2026 5148700 152 µM -1.19079374210698 0.109233685928151 no 3013 0.116867283090266 980 79838 SGTC_3268 9137683 49.47 µM -1.19197137872834 0.108997219344072 no 3014 0.116636234015188 1023 1953228 SGTC_2942 9052777 62.25 µM -1.19201786785674 0.108987891994775 no 3015 0.116627119626281 988 6469503 SGTC_1016 4226-1401 38 µM -1.19452654738422 0.108485413443412 no 3016 0.116136031248912 974 2901613 SGTC_675 1309-0189 238 µM -1.19489677750237 0.108411399182042 no 3017 0.116063681046967 966 4246530 SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM -1.19687303061382 0.108016932673632 no 3018 0.115678023748287 971 2374 Ca(2+)-ATPase inhibitor. SGTC_145 3737-0113 38.366 µM -1.1984869562979 0.107695555336389 no 3019 0.115363748988709 958 6849351 SGTC_1602 st001878 87.6 µM -1.20296171479204 0.106808111019863 no 3020 0.11449556815058 973 595405 YLR310C CDC25 SGTC_947 3447-0010 211 µM -1.20346190457721 0.106709241080176 no 3021 0.1143988124028 974 748350 SGTC_1112 tnp00069 1.16933 µM -1.20721187982983 0.105970106066778 no 3022 0.113675278257249 973 145826 SGTC_1881 5652484 16 µM -1.20990417528333 0.105441730310573 no 3023 0.113157832454804 979 2255129 SGTC_162 k030-0015 37.8 µM -1.21086376721304 0.105253867236309 no 3024 0.112973810526405 996 1809920 YMR134W ERG29 SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM -1.21138055809638 0.105152793448746 no 3025 0.112874793547724 995 6708561 SGTC_3201 9113999 49.47 µM -1.21512088277946 0.104423355301376 no 3026 0.112159994974742 977 16649224 SGTC_46 0329-0187a 2.197 µM -1.21568585252176 0.104313494413141 no 3027 0.112052307748046 968 46494817 SGTC_2853 9015042 58.44 µM -1.21605123932498 0.104242487938478 no 3028 0.111982701813074 956 6457456 SGTC_425 3825-7017 13.1 µM -1.219943240911 0.103488319329836 no 3029 0.111243196117303 963 3397440 SGTC_2301 7769476 200 µM -1.22014212774554 0.103449886868502 no 3030 0.111205500441633 973 977820 SGTC_1195 1502-0147 41.1 µM -1.22452567163408 0.10260544915657 no 3031 0.110376994039331 962 817940 SGTC_2885 9057732 51.95 µM -1.22728666045749 0.10207615573789 no 3032 0.109857433765576 973 6471414 SGTC_2337 9009472 200 µM -1.23078675673687 0.10140803137087 no 3033 0.109201314967387 966 5742383 SGTC_753 1322-0200 289 µM -1.23229382809853 0.101121333603939 no 3034 0.108919672246427 983 5403907 SGTC_2098 5376439 882.5 nM -1.23362621037078 0.100868360200803 no 3035 0.108671110795634 979 2844116 SGTC_894 0960-0238 55.9 µM -1.23797173104448 0.100046502939288 no 3036 0.107863271459797 990 6741907 YDL195W SEC31 SGTC_2953 9074162 66.49 µM -1.24018337615674 0.0996301025069301 no 3037 0.107453787842351 957 16451992 SGTC_2934 9036370 36.88 µM -1.24253938013102 0.0991879173124817 no 3038 0.10701881013253 948 6462800 SGTC_128 0906-2981 13.371 µM -1.24358358686387 0.0989923956503177 no 3039 0.106826429987905 984 6740226 SGTC_2188 6126565 140.678 µM -1.24599773286579 0.0985414405119865 no 3040 0.106382613754536 967 874518 SGTC_111 0083-0039 52.457 µM -1.24692014358357 0.0983695346879572 no 3041 0.106213389948917 958 759313 SGTC_2755 lomerizine 42.69 µM -1.24702911279878 0.0983492410650754 no 3042 0.106193411502396 966 3949 A calcium channel blocker. SGTC_2210 7115885 190.385 µM -1.24819790621803 0.0981317663803837 no 3043 0.105979295273344 1000 2927039 SGTC_3103 9120822 49.47 µM -1.24959573810809 0.0978721379274996 no 3044 0.105723630388998 983 17141819 SGTC_2565 isoliquiritigenin 100 µM -1.25057234757146 0.0976910448586109 no 3045 0.105545272298507 952 638278 Binds to benzodiazepine receptor 65X better than valium. SGTC_1929 genistein trimethyl ether 50.5 µM -1.25202974929749 0.0974212553464604 no 3046 0.105279511978625 952 136420 SGTC_2769 toremifene 3.73 µM -1.25724150123189 0.096460944525944 no 3047 0.10433309979855 989 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_1873 rapamycin 2 nM -1.26006154943107 0.0959442348901742 no 3048 0.103823579809301 969 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1 SGTC_2008 4012253 172 µM -1.26028589008833 0.0959032171463663 no 3049 0.103783124080751 958 603940 SGTC_2945 9067681 61.76 µM -1.26042588356264 0.0958776277135583 no 3050 0.103757884616884 1000 16456930 SGTC_960 1222-0186 7.7 µM -1.26053831721925 0.0958570795814846 no 3051 0.103737617144952 996 3126296 SGTC_1844 rapamycin 4 nM -1.26193616888891 0.0956018816557702 no 3052 0.103485877943032 933 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2 SGTC_2673 kobusone 100 µM -1.26281824571652 0.0954411033301174 no 3053 0.103327253004642 1019 6710676 An epoxy ketone and protein crosslinker. SGTC_1223 0764-0573 147 µM -1.26432972020031 0.0951660659945801 no 3054 0.103055853247904 984 1609797 SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM -1.26622029731313 0.0948228669753721 no 3055 0.102717111319426 991 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_2989 9073649 71.4286 µM -1.26891290520859 0.0943356498829819 no 3056 0.102236064507922 985 21367202 SGTC_834 0312-0008 75.7 µM -1.27040163900339 0.0940670630428596 no 3057 0.10197079986916 1004 6385573 YIL048W NEO1 SGTC_782 0083-0095 30.5 µM -1.27220442365591 0.0937425731962752 no 3058 0.101650248151419 990 3591729 An indicator and reagent. SGTC_2133 5320837 200 µM -1.27362546066639 0.0934873784919901 no 3059 0.101398092271563 1005 2841355 SGTC_3331 9141060 1.957 µM -1.27471895529183 0.0932913545756296 no 3060 0.10120436758394 971 4906567 YPR165W RHO1 SGTC_2332 7982454 138.89 µM -1.27619053703003 0.0930280329087741 no 3061 0.10094408647576 995 2981748 SGTC_2516 gossypol 71.55 µM -1.28002311104459 0.092344819630141 no 3062 0.10026850399675 1001 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_2846 9008642 19.48 µM -1.28144107649849 0.092092989542556 no 3063 0.100019392016148 1016 2992898 SGTC_1706 st031321 9.9705 µM -1.28263653228032 0.0918810724145394 no 3064 0.0998097225004792 979 6103185 SGTC_3115 9123671 49.47 µM -1.28776847823534 0.0909754403538424 no 3065 0.098913284048565 1017 3286988 SGTC_2138 5575593 77.673 µM -1.29556268104145 0.089612691716495 no 3066 0.0975630966437082 995 762213 SGTC_3037 9091026 49.47 µM -1.29586625056021 0.0895599240056159 no 3067 0.0975107842078519 989 25236398 YIL048W NEO1 SGTC_391 gliotoxin 8.33 µM -1.29645398312566 0.089457827576358 no 3068 0.0974095620204316 988 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion SGTC_1619 st003326 88.7 µM -1.29664357504412 0.0894249115841658 no 3069 0.0973769260174698 928 2849032 SGTC_592 k241-0073 46.5 µM -1.29691584873207 0.0893776565599839 no 3070 0.097330071359611 1002 4230158 SGTC_1002 4049-0206 172 µM -1.29702257566155 0.089359138415118 no 3071 0.0973117095965124 975 4662749 SGTC_2002 4023503 131 µM -1.29802851577305 0.0891847383773856 no 3072 0.0971387681561291 1000 4736863 YCR052W RSC6 SGTC_2811 7967822 32.47 µM -1.30483999224661 0.0880104902256371 no 3073 0.0959736690472164 980 2232244 SGTC_1082 camptothecin 424.86 nM -1.30643326100009 0.087737493646827 no 3074 0.0957026305015637 957 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_1438 4092-1045 4 µM -1.30905534615147 0.0872895919014151 no 3075 0.0952578018176783 989 1351342 SGTC_2448 5185112 27.17 µM -1.31252110907153 0.0867001962982344 no 3076 0.0946721842253513 961 5718189 SGTC_1859 st055998 20 µM -1.3192069359918 0.0855716004697797 no 3077 0.0935499700600033 1003 676301 SGTC_144 4161-2749 112.381 µM -1.32577871605876 0.0844730127705474 no 3078 0.0924565024812754 986 797501 YMR168C CEP3 SGTC_1754 st042065 16.137 µM -1.32592786007145 0.0844482041205705 no 3079 0.0924317968707643 954 1126236 YIL048W NEO1 SGTC_207 4185-0010 4.486 µM -1.33001956635182 0.0837697191189778 no 3080 0.0917559123369913 985 3761753 SGTC_982 1491-0518 27.5 µM -1.33058351909231 0.0836765266997104 no 3081 0.0916630441787289 995 3091256 SGTC_2977 9011197 71.43 µM -1.33065351024398 0.0836649661929166 no 3082 0.0916515233397527 971 2704722 SGTC_494 Boc-Gly-Val-Val-CHO 140 µM -1.33248839623659 0.0833623241960711 no 3083 0.0913498759949259 1000 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA. SGTC_1641 st009299 47.1 µM -1.3326952790817 0.0833282530902146 no 3084 0.0913159115706264 987 4046054 SGTC_417 st075190 100 µM -1.33376225599267 0.0831527010759342 no 3085 0.0911408922025996 1002 222757 SGTC_1443 4112-3303 14 µM -1.3347296614656 0.0829937722871918 no 3086 0.0909824209705201 1009 704433 SGTC_359 0081-0058 15.9 µM -1.33782523828068 0.082486755213247 no 3087 0.0904767063057129 998 3494159 SGTC_2947 9072639 7.68 µM -1.33813115369743 0.0824367769465507 no 3088 0.0904268434031176 1022 16488146 SGTC_1151 3909-8316 15.3 µM -1.3395393963887 0.0822070023652356 no 3089 0.0901975690183069 1015 800431 SGTC_1951 sophoraflavanone G 9.2 µM -1.3396506460635 0.08218887099744 no 3090 0.0901794750063086 985 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity. SGTC_995 3931-2021 34.6 µM -1.34050087548595 0.0820504008677955 no 3091 0.0900412799428689 1020 730143 SGTC_146 3448-8650 53.125 µM -1.34061437965574 0.0820319286490923 no 3092 0.0900228430507224 1016 2891488 YIL048W NEO1 SGTC_105 0111-0055 734.78 µM -1.34283321502547 0.0816714536504089 no 3093 0.0896629927960202 1002 5179370 SGTC_248 streptozotocin 5.23457 mM -1.3437582146533 0.0815215301490454 no 3094 0.0895132928184049 994 5300 DNA alkylating agent. SGTC_1741 st038134 10.228 µM -1.35106609062122 0.080344361724094 no 3095 0.0883371312910627 1010 1272587 SGTC_2355 9061122 103.12 µM -1.35507106307632 0.0797047044512942 no 3096 0.0876974585413162 1028 5302957 SGTC_2630 antimycin a 100 µM -1.35822716137154 0.0792033457987043 no 3097 0.0871958072518723 1009 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain. SGTC_2762 leflunomide 42.06 µM -1.35914787922285 0.0790575369723116 no 3098 0.0870498667165073 1019 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1 SGTC_536 3852-0578 10.6 µM -1.36165156190815 0.0786620710963167 no 3099 0.0866539372857596 1015 2869208 SGTC_993 3909-8757 62.7 µM -1.3653106088257 0.078086810260575 no 3100 0.0860777230097912 1001 4288324 YLR208W SEC13 SGTC_369 0957-0393 4.5 µM -1.36761550380166 0.0777260856261572 no 3101 0.0857162304689627 1001 6997992 SGTC_735 3076-0345 636 µM -1.36817781229616 0.0776382744970734 no 3102 0.0856282124577318 1000 2888990 SGTC_204 PMA1.184 62.41 µM -1.36824503210462 0.0776277823700648 no 3103 0.0856176950875656 1010 2252213 YGL008C PMA1 SGTC_1466 k213-0079 57.5 µM -1.36837698976842 0.0776071886472008 no 3104 0.0855970514926342 1025 3657981 SGTC_54 0159-0055 9 µM -1.37681553392746 0.0762988394565373 no 3105 0.0842846434616316 1010 3319099 SGTC_1426 4048-4480 71.7 µM -1.37820752282286 0.0760846416160734 no 3106 0.0840696126350553 1002 14224343 SGTC_2987 9018338 71.43 µM -1.37850555294939 0.0760388405965998 no 3107 0.0840236272939306 999 5055682 SGTC_2090 5301565 104.445 µM -1.38157875137086 0.0755677775242238 no 3108 0.0835505410143011 1001 2056344 SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM -1.38286513927097 0.0753712600964824 no 3109 0.0833531105843486 1012 16623 A steroid. SGTC_3266 9136860 49.47 µM -1.38344920927231 0.0752821622473292 no 3110 0.0832635853587026 967 4871271 YPR165W RHO1 SGTC_2468 5987765 72.9 µM -1.390172664491 0.0742622966344487 no 3111 0.0822382260356151 1010 26772094 SGTC_648 0375-0473 33.3 µM -1.39055917431931 0.0742039901361557 no 3112 0.0821795717833782 1010 1713139 SGTC_2422 chlorphenesin carbamate 384.24 µM -1.39079530009973 0.0741683868602177 no 3113 0.0821437543582333 999 2724 A muscle relaxant with antifungal properties. SGTC_2323 6148992 148.28 µM -1.39578112316307 0.073419662450155 no 3114 0.0813902082576416 989 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42 SGTC_2072 5231554 129 µM -1.39703370127351 0.0732324736011563 no 3115 0.0812017184578165 1001 789545 SGTC_1922 5578187 25 µM -1.39712218617185 0.0732192639856994 no 3116 0.0811884155855222 960 1350412 SGTC_153 4077-0274 519.67 µM -1.40078433816484 0.0726741510521583 no 3117 0.0806392867337916 986 3121976 SGTC_2051 5263410 176 µM -1.40481191485761 0.0720782389470905 no 3118 0.0800386075510677 1007 227584 SGTC_1378 2093-0007 380 nM -1.40532353859246 0.0720028090544587 no 3119 0.0799625459706326 1016 3618014 SGTC_535 2293-4129 48.2 µM -1.40841507985322 0.071548303004168 no 3120 0.0795040982486221 1029 396118 YIL048W NEO1 SGTC_2272 7805186 180 µM -1.40960416953626 0.0713740751627192 no 3121 0.079328297580673 1016 2956062 YPR165W RHO1 SGTC_836 0330-0104 1.35 µM -1.41148591264498 0.0710990240032447 no 3122 0.0790506932668898 978 46494820 SGTC_1803 st050068 52.4 µM -1.41198658354035 0.0710259790687453 no 3123 0.0789769558140441 999 3984059 YIL048W | YNL267W NEO1 | PIK1 SGTC_2653 dihydrofissinolide 100 µM -1.41306962653317 0.0708681666756024 no 3124 0.0788176264334086 1026 6857746 SGTC_2878 9043973 25.97 µM -1.41664074542381 0.0703497197781538 no 3125 0.0782939946986932 1027 6465167 SGTC_524 r073-0010 27.8 µM -1.42032545771109 0.0698178437219657 no 3126 0.0777564765042876 1016 2772106 SGTC_927 2425-1185 123 µM -1.42170051049772 0.0696201542778846 no 3127 0.0775566059364492 1010 730375 SGTC_974 1326-0144 138 µM -1.42260551975105 0.0694902776941595 no 3128 0.0774252714933226 1019 5411856 SGTC_901 1112-0062 60.1 µM -1.42346934483758 0.0693664855053828 no 3129 0.0773000712960929 999 1908457 SGTC_49 0717-0965 32.132 µM -1.42475781132639 0.0691821549553632 no 3130 0.077113610721935 1025 5889349 YGL099W LSG1 SGTC_3323 9138564 53.9225 µM -1.4259899918065 0.0690062300573665 no 3131 0.0769356154870935 1007 43912313 YNL103W MET4 SGTC_811 0416-0114 265 µM -1.4262224364733 0.0689730813992222 no 3132 0.076902072620972 1000 6612453 SGTC_348 k064-0012 10.7 µM -1.42893227566683 0.0685875394935291 no 3133 0.0765118498418572 1008 5066323 SGTC_1876 myriocin 605 nM -1.43832319602365 0.06726430082746 no 3134 0.0751711866578383 1006 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1 SGTC_1414 3917-0015 5.4 µM -1.43839814721411 0.0672538197009211 no 3135 0.0751605590209245 1012 6618702 SGTC_1980 st071811 45.7 µM -1.44217831515416 0.0667268394025504 no 3136 0.0746260381761862 1017 4974850 SGTC_1458 k015-0034 6.33 µM -1.44596795965871 0.0662017510780839 no 3137 0.0740930943650656 1027 3598957 SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM -1.44714480877603 0.0660393412953569 no 3138 0.0739281852095021 1044 442882 SGTC_719 2810-4230 27.3 µM -1.45455740173119 0.0650234606613872 no 3139 0.0728959156476409 1032 721079 SGTC_9 0092-0002 10.449 µM -1.46375628792223 0.0637796871319976 no 3140 0.0716302749054224 1017 759368 SGTC_322 k048-0136 19.3 µM -1.46824229133267 0.0631798900666479 no 3141 0.0710192101433682 1028 6823282 SGTC_2021 4019055 173 µM -1.46919822250145 0.0630526476678092 no 3142 0.0708895161438948 1011 44827708 YER133W GLC7 SGTC_316 k060-0003 58.6 µM -1.47515370477952 0.0622644135468189 no 3143 0.0700856123332753 1033 6152314 SGTC_585 0kpi-0023 191 µM -1.4772404673709 0.0619900469537807 no 3144 0.0698055948876732 1006 64601 SGTC_3182 9108849 49.47 µM -1.47873839150992 0.0617936829079753 no 3145 0.0696051236623104 1014 17133045 SGTC_843 0310-0051 143 µM -1.47934463259371 0.0617143484494826 no 3146 0.0695241149002188 1031 2065037 SGTC_1963 st076565 50.3 µM -1.48268800874456 0.0612782522994523 no 3147 0.0690786610054254 1036 4914280 SGTC_2297 7971671 152.32 µM -1.48432467606223 0.0610656518478754 no 3148 0.0688614034813674 1019 909016 SGTC_1571 st070080 73.4 µM -1.48555600904218 0.0609060840479009 no 3149 0.0686982991252467 1002 4315245 SGTC_1362 1611-0397 101 µM -1.48619943290597 0.0608228328638019 no 3150 0.0686131887547162 1021 27816 SGTC_397 arbidol 50 µM -1.49057311052097 0.0602592884986991 no 3151 0.0680368041916133 1023 131410 A RNA synthesis inhibitor. SGTC_1730 st033808 45.1 µM -1.49115646518596 0.0601844337058451 no 3152 0.0679602102545934 1012 1045166 SGTC_3322 9139058 2.11 µM -1.49613826469376 0.0595481419175807 no 3153 0.0673088141152944 1027 4908926 YPR165W RHO1 SGTC_2623 humulene 100 µM -1.49981518719835 0.0590819042336327 no 3154 0.0668311410965764 1026 6187145 An anti-inflammatory. SGTC_1719 st032227 49.2 µM -1.50361080658669 0.0586036241661339 no 3155 0.0663408034904718 998 3125804 SGTC_809 3998-0021 90 µM -1.50468452160122 0.0584688800213505 no 3156 0.0662026021901888 1015 715485 SGTC_1280 0880-0253 10.1 µM -1.50607199942978 0.0582951211608866 no 3157 0.0660243458583638 1013 6836607 SGTC_436 n,n-dimethylsphingosine 3.3 µM -1.51001651123449 0.0578033509485184 no 3158 0.0655196055631628 1024 5282309 SGTC_1998 st075797 76.8 µM -1.51232490620984 0.0575170751343958 no 3159 0.0652256140081429 1014 24208315 SGTC_1681 tripelennamine 100 µM -1.51499267099244 0.0571876225312395 no 3160 0.0648871300750446 1001 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist. SGTC_2353 9059630 146.67 µM -1.51567081339377 0.0571041133096104 no 3161 0.0648013056496249 1041 4779114 SGTC_2593 nobiletin 86.24 µM -1.5172768453878 0.0569067228494274 no 3162 0.0645984008331482 1008 72344 An anti-infammatory. SGTC_1588 farnesol 29.9 µM -1.52448214467479 0.0560277554416071 no 3163 0.0636941569245826 1018 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_526 4469-0568 170 µM -1.5252029234798 0.0559404207395339 no 3164 0.0636042458232081 1006 2901964 SGTC_657 3534-0529 86.7 µM -1.52554779945602 0.0558986711074254 no 3165 0.0635612603881018 1052 1049549 SGTC_1027 k015-0025 8.67 µM -1.52776955095823 0.0556303016214043 no 3166 0.0632848823825715 1022 3598955 SGTC_2159 5658611 73.75 µM -1.52824516943895 0.0555729831478831 no 3167 0.0632258388947136 1023 793844 SGTC_2704 st078022 71.1 µM -1.52873844428528 0.0555135860992002 no 3168 0.0631646488569366 1020 54697681 SGTC_1648 st011736 69.8 µM -1.53032382641924 0.0553230237081317 no 3169 0.0629682967304001 1036 2855514 SGTC_3072 9116419 49.47 µM -1.53652730602597 0.0545823286323835 no 3170 0.0622045530082932 1019 17170162 SGTC_1308 1187-1617 41.4 µM -1.5367229469163 0.0545590973072829 no 3171 0.062180584666543 1027 2882570 SGTC_15 0266-0086 27.098 µM -1.53682603457408 0.0545468593369443 no 3172 0.0621679580978237 1051 1712902 YIL048W NEO1 SGTC_1356 1502-0781 85.8 µM -1.53813337501748 0.0543918477060894 no 3173 0.0620080035339257 1024 567702 SGTC_2059 5238311 157 µM -1.54148759473239 0.0539957309288975 no 3174 0.0615990799127154 1016 703021 SGTC_2319 6033012 152.6 µM -1.54212861812285 0.0539202897928395 no 3175 0.0615211709252012 1024 847246 SGTC_1612 st002233 45.4 µM -1.54468374885359 0.0536204090189212 no 3176 0.0612113888128064 1011 1035021 SGTC_2429 5902844 64.44 µM -1.5478592167213 0.0532495658508114 no 3177 0.0608280977857709 1015 1927790 YGL093W | YPR107C SPC105 | YTH1 SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM -1.54829925577199 0.0531983371972647 no 3178 0.0607751317808198 1021 1241132 A phosphatase inhibitor. SGTC_1289 0976-0073 69.1 µM -1.55045022859597 0.0529484863678704 no 3179 0.0605167453686631 1028 3391136 SGTC_1679 SEC14.276 6.7 µM -1.55139279689835 0.0528392940259921 no 3180 0.0604037901849735 1010 1005053 YMR079W SEC14 SGTC_2655 perillic acid 100 µM -1.55220762802883 0.0527450434947669 no 3181 0.0603062757472794 1047 5702197 An apoptosis inducer. SGTC_1575 cyproterone acetate 48 µM -1.55772808247076 0.0521100076632085 no 3182 0.0596488602633917 1029 9880 An androgen receptor antagonist and liver toxin. SGTC_60 0986-0278 202 µM -1.55789684051724 0.0520906909655468 no 3183 0.0596288521542723 1044 3110598 SGTC_513 4245-1575 41.7 µM -1.5591887518534 0.051943002191414 no 3184 0.0594758561509253 1002 719745 SGTC_1163 k060-0048 49.9 µM -1.55971529860151 0.0518829039178087 no 3185 0.0594135876128265 1046 6809982 SGTC_1732 st034308 51.822 µM -1.56304332956307 0.0515043310039869 no 3186 0.0590212018069668 1006 830119 SGTC_2611 pyromycin 23.93 µM -1.57075297482661 0.0506357748349864 no 3187 0.0581200194630923 1029 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release. SGTC_3178 9107506 49.47 µM -1.57103252851323 0.0506045013070022 no 3188 0.0580875466308723 1027 8897194 SGTC_209 4077-0173 175.592 µM -1.5724918556461 0.0504414968330014 no 3189 0.0579182632460932 1033 15993494 SGTC_281 1672-3440 14.9 µM -1.5734448461171 0.0503352753378794 no 3190 0.057807924878788 1032 6833000 SGTC_24 0417-1663 219 µM -1.57780216644727 0.0498518719984852 no 3191 0.0573055329914985 1052 4329390 SGTC_3057 9095946 49.47 µM -1.57869934162372 0.0497528001355755 no 3192 0.0572025179584046 1046 24540043 SGTC_1244 0416-0015 52.5 µM -1.58050398611217 0.0495539954348918 no 3193 0.0569957473817051 1038 96201 SGTC_3167 9103034 49.47 µM -1.58107649947521 0.0494910583926409 no 3194 0.0569302736730076 1049 5127859 SGTC_2240 6690706 185.951 µM -1.58131902693414 0.0494644163201925 no 3195 0.056902555639682 1023 805876 SGTC_2405 ticlatone 3.52 µM -1.58207356459975 0.0493816022219457 no 3196 0.056816388825725 1022 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W SGTC_1800 st050079 29.0735 µM -1.5832718291399 0.0492503144946802 no 3197 0.0566797604442047 1015 3645560 SGTC_1297 1068-0111 14.1 µM -1.58382840129106 0.0491894285967691 no 3198 0.0566163871328318 1022 767057 SGTC_640 3381-0960 37.1 µM -1.58667029412177 0.0488794778443442 no 3199 0.0562936688260179 1041 1745025 SGTC_1879 gemcitabine 100 µM -1.59005761615352 0.0485120807418655 no 3200 0.0559109092340334 1036 60750 A nucleoside analog which inhibits DNA replication. SGTC_227 fluconazole 33.516 µM -1.59092718548729 0.0484181222262308 no 3201 0.0558129818184545 1032 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C SGTC_2709 st078560 56 µM -1.60104219960719 0.0473358364315832 no 3202 0.0546837864005709 1042 17250903 SGTC_2490 carminic acid 95.39 µM -1.60324985491195 0.0471022186234168 no 3203 0.0544397512872762 1026 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_345 1362-0200 395 µM -1.60540597605714 0.0468749473915163 no 3204 0.0542022450556156 1043 1419823 SGTC_1597 7-benzyloxygramine 47.5 µM -1.60546462432825 0.0468687777359909 no 3205 0.0541957961637518 1011 260807 SGTC_1459 k035-0031 35.7 µM -1.60700606286424 0.0467068555412318 no 3206 0.0540265190654047 999 3877128 YMR208W ERG12 SGTC_231 b-estradiol 524 µM -1.61009051678485 0.0463841932351992 no 3207 0.0536890485295787 1038 450 A steroid. SGTC_1665 st014639 11.4 µM -1.61087741971033 0.0463021630813183 no 3208 0.0536032212332284 1036 981133 YIL048W NEO1 SGTC_604 1000-0114 314 µM -1.61671305507184 0.0456974602897956 no 3209 0.0529701172773643 1057 1572745 SGTC_307 1501-1223 22.3 µM -1.61761473717885 0.0456045945587996 no 3210 0.0528728255450264 1040 2830329 SGTC_82 0054-0107 293.755 µM -1.61944533822651 0.0454165246515789 no 3211 0.0526757392685107 1044 3104697 SGTC_1131 3454-3128 32.3 µM -1.62264980478627 0.0450888103895599 no 3212 0.0523321436411025 1012 710982 SGTC_2222 6885208 172.143 µM -1.62411214082906 0.0449398939542872 no 3213 0.05217593865059 1057 609514 SGTC_2086 5274770 176.623 µM -1.62615807473204 0.0447322117773006 no 3214 0.0519580161856208 1034 689278 SGTC_1322 1348-1070 12 µM -1.629786475859 0.0443657951256569 no 3215 0.051573316544514 1036 6758089 SGTC_2781 5567276 71.43 µM -1.63384159526827 0.0439591522369612 no 3216 0.0511460579249559 1023 2853274 SGTC_507 nimesulide 162 µM -1.63526705521757 0.0438169247404048 no 3217 0.0509965383232521 1037 4495 A COX2 inhibitor. SGTC_2481 5478948 45.16 µM -1.63617453124024 0.0437265734476951 no 3218 0.0509015325736322 1031 77792 SGTC_659 k018-0002 107 µM -1.63922082323801 0.0434243733453534 no 3219 0.0505836393131038 1039 6797879 YHR007C ERG11 SGTC_800 3448-7362 155 µM -1.65343965772064 0.0420360585573833 no 3220 0.0491207086864477 1047 15991913 SGTC_1857 st056007 79.3 µM -1.65902945802171 0.0415002091865126 no 3221 0.0485549282270592 1041 619834 SGTC_2419 paclitaxel 166.5 µM -1.66668983976633 0.0407748735673926 no 3222 0.0477880471236783 1031 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_2028 5153890 36.43 µM -1.66839180467639 0.0406151249897125 no 3223 0.0476189870399324 1047 2830968 YPR165W RHO1 SGTC_511 blebbistatin 171 µM -1.67086594581097 0.0403838053365146 no 3224 0.0473740796275007 1050 3476986 A myosin inhibitor. SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM -1.67663870587892 0.0398482403092255 no 3225 0.0468065765699206 1028 17037758 SGTC_1992 st073643 23.3 µM -1.68091570260149 0.0394551790094936 no 3226 0.0463896447346395 1054 3161292 SGTC_2666 tannic acid 100 µM -1.6939690760895 0.0382750232865722 no 3227 0.0451355797291417 1028 16134267 A thiamine antagonist. SGTC_1385 3091-4834 14.1 µM -1.69575926103192 0.0381154404775367 no 3228 0.0449657402662102 1046 4072814 SGTC_531 3788-1495 174 µM -1.71507793600413 0.0364276043404546 no 3229 0.0431654694835894 1031 2896655 SGTC_3286 9117135 37.221 µM -1.72177828597321 0.0358566902058245 no 3230 0.0425548447588781 1048 3438150 SGTC_614 0462-0418 107 µM -1.72452345329334 0.035624910580396 no 3231 0.0423066943792234 1024 5188303 SGTC_2354 9060492 162 µM -1.73124676155557 0.0350624329472763 no 3232 0.0417038811892946 1043 6471895 SGTC_1408 3909-7976 48.8 µM -1.73394999638186 0.0348383417867892 no 3233 0.0414634778907584 1046 24152374 SGTC_1207 2099-0101 141 µM -1.73840743146746 0.0344714008114802 no 3234 0.0410695240851793 1045 5837381 SGTC_1735 st034310 56.75 µM -1.7509232885523 0.0334580268182879 no 3235 0.0399795623342786 1036 871153 SGTC_570 0987-0065 62.6 µM -1.75113892796142 0.0334407843748706 no 3236 0.0399609910949717 1022 3104428 SGTC_741 4582-0002 126 µM -1.76152077798681 0.0326192708153867 no 3237 0.0390751496988807 1042 2912688 SGTC_1357 1503-1303 39.5 µM -1.76289617017661 0.0325116955631824 no 3238 0.0389590015550775 1046 292895 SGTC_2417 cerulenin 830 nM -1.76323709483015 0.0324850757102287 no 3239 0.0389302549120207 1043 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1 SGTC_868 0527-0199 213 µM -1.76605652528379 0.0322656193143361 no 3240 0.0386931830852895 1053 2849450 SGTC_3143 9086658 49.47 µM -1.76892556089071 0.032043559320119 no 3241 0.0384531489536477 1025 25236626 SGTC_2404 5161160 200 µM -1.77106528069971 0.0318787702840574 no 3242 0.0382749233564281 1032 2831543 SGTC_2409 alverine citrate 63.97 µM -1.77519316709044 0.0315628416562602 no 3243 0.0379329987882623 1028 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_2957 9076800 11.52 µM -1.786401423971 0.0307180469779783 no 3244 0.0370171426161271 1055 16459615 SGTC_5 0352-0601 109.883 µM -1.7874892286057 0.0306370625552232 no 3245 0.0369292257536846 1035 762456 SGTC_1981 st071826 47 µM -1.79020362429797 0.0304357531698633 no 3246 0.036710591338046 1041 11838600 SGTC_2868 9035608 32.47 µM -1.79158217814952 0.0303339349955279 no 3247 0.0365999600165924 1055 6462614 SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM -1.79233916051708 0.0302781454276964 no 3248 0.0365393269765323 1071 6708784 An antioxidant flavonoid SGTC_1425 4048-4433 7.33 µM -1.79529777723456 0.0300609105820379 no 3249 0.0363031345028815 1072 23734946 SGTC_2897 9048598 12.99 µM -1.79660320106975 0.0299654722590614 no 3250 0.036199317933077 1073 6467404 SGTC_2343 7990716 14.84 µM -1.80145351600564 0.0296130689598428 no 3251 0.0358157138225044 1055 6456862 SGTC_520 3584-0023 682 µM -1.80842903716912 0.0291122933848233 no 3252 0.0352698760230542 1041 1340790 SGTC_962 1254-0300 21.5 µM -1.81755842961004 0.0284675396905347 no 3253 0.0345658250939045 1052 7340576 SGTC_2306 7482397 179.52 µM -1.81988714008086 0.0283049921734585 no 3254 0.034388096852221 1066 891448 SGTC_892 0929-0076 29 µM -1.82040047027651 0.0282692650475087 no 3255 0.034349020438678 1043 5751038 SGTC_1150 3909-7983 10.9 µM -1.82764646844677 0.027768944665396 no 3256 0.0338013134957629 1057 23965914 SGTC_1320 1313-0481 95.3 µM -1.83399851007752 0.0273364397017294 no 3257 0.0333271076581257 1052 6813365 YLR208W SEC13 SGTC_2043 5101342 149 µM -1.83940648213449 0.0269726570075915 no 3258 0.0329277107098384 1070 678451 SGTC_1818 st052136 56.3 µM -1.86397979307479 0.0253701801861002 no 3259 0.0311622710342994 1022 674169 SGTC_3307 9126885 69.2785 µM -1.87525108189581 0.0246622813291967 no 3260 0.0303790948416702 1065 24824909 SGTC_2643 anethole 100 µM -1.87797274716187 0.024493852203768 no 3261 0.0301924466889394 1063 637563 An anti-fungal, anti-helmenthic and channel blocker. SGTC_43 0570-0105 72.5 µM -1.8804206415546 0.0243431909845156 no 3262 0.0300253862773164 1054 1114046 YDL195W SEC31 SGTC_1864 st057645 30.4 µM -1.88290962460308 0.0241907994421623 no 3263 0.0298563083397154 1066 688666 SGTC_290 2043-6722 48.1 µM -1.88853527707193 0.0238493111835329 no 3264 0.0294770633256776 1058 773758 YLR208W SEC13 SGTC_361 000s-0510 1.45 µM -1.89436463767283 0.0234997415140344 no 3265 0.0290883134105664 1039 660 SGTC_2070 5230947 200 µM -1.89536634612382 0.023440108115717 no 3266 0.029021942011208 1069 2835538 SGTC_1441 4106-0040 13 µM -1.89763102106968 0.0233057573805437 no 3267 0.0288723525062395 1063 2904180 SGTC_1653 st012112 65 µM -1.89818510231224 0.0232729856432138 no 3268 0.0288358512996253 1050 720429 SGTC_681 1642-0006 26.6 µM -1.90052161792789 0.0231352162326094 no 3269 0.0286823503870528 1081 4446530 SGTC_838 0109-0203 71.4 µM -1.90443691193914 0.0229058959043678 no 3270 0.0284266528711363 1054 759422 SGTC_773 4358-1457 44.6 µM -1.91267476812329 0.0224296497212234 no 3271 0.0278948506481688 1074 1186886 SGTC_197 4544-0043 41.561 µM -1.92071494015772 0.0219729120226381 no 3272 0.0273838275220474 1064 896523 SGTC_1780 st038448 24.544 µM -1.92234273234045 0.0218814043095635 no 3273 0.0272813231843894 1053 728868 YDL195W SEC31 SGTC_2413 inermin 26.06 µM -1.93863031048085 0.0209833749325151 no 3274 0.0262731850059355 1030 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1 SGTC_1299 1079-1439 3.74 µM -1.95134611849695 0.0203041401879542 no 3275 0.0255079432055963 1063 323161 SGTC_1358 1509-0022 2.48 µM -1.95204337137821 0.0202674406728414 no 3276 0.0254665277765445 1064 3258434 SGTC_2216 7189485 200 µM -1.9596556670148 0.0198704171332805 no 3277 0.025018025084652 1065 731273 SGTC_2803 7707263 71.43 µM -1.96761349917378 0.0194624477492701 no 3278 0.0245562626656351 1055 2199229 SGTC_1596 piperlongumine 63 µM -1.97657050769354 0.0190117873785747 no 3279 0.0240450992834912 1052 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_2867 9039098 71.43 µM -2.00780803700914 0.0175089173792811 no 3280 0.022331847233005 1042 6463460 SGTC_912 3474-0017 2.18 µM -2.01193888769369 0.017317981979327 no 3281 0.0221131897278519 1070 3360550 SGTC_2956 9076196 2.52 µM -2.03100453958853 0.016459615460001 no 3282 0.0211272670504692 1084 16423868 SGTC_140 0062-0056 502.533 µM -2.0373166417623 0.016183579119164 no 3283 0.0208091606017464 1066 3758964 SGTC_2787 5284540 71.43 µM -2.04485992806167 0.0158589121758143 no 3284 0.0204343347606169 1065 736958 SGTC_129 0088-0017 176.636 µM -2.04534785930646 0.0158381050555134 no 3285 0.0204102877417196 1072 182446 SGTC_1852 st056254 31.4 µM -2.05683668922151 0.0153549022880528 no 3286 0.0198509687956333 1075 442583 SGTC_233 rapamycin 362 pM -2.06811410146159 0.0148929580480748 no 3287 0.019314647497517 1081 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C SGTC_3293 9120939 62.045 µM -2.08090592792202 0.0143834921526284 no 3288 0.01872125873048 1069 934087 SGTC_3290 9121031 71.43 µM -2.08570171316756 0.0141963936302643 no 3289 0.0185028255842784 1058 17014854 SGTC_3285 9112818 20.8695 µM -2.08958648901555 0.0140463771655298 no 3290 0.0183274806308033 1067 17017947 YPR165W RHO1 SGTC_1672 st016598 6.51 µM -2.09025212310991 0.0140208102902841 no 3291 0.0182975787827066 1066 4665860 YNL267W PIK1 SGTC_849 0386-0493 241 µM -2.09333350002365 0.0139029771873758 no 3292 0.0181596970863137 1073 726119 SGTC_2146 5545642 200 µM -2.11034629946839 0.0132676568326388 no 3293 0.0174142691615591 1070 825326 SGTC_2194 5927483 104.545 µM -2.12592843420393 0.012707925574506 no 3294 0.0167546094499226 1078 760979 SGTC_721 1187-1332 279 µM -2.12700093061364 0.0126701629768499 no 3295 0.0167100029353046 1081 25730 SGTC_1607 st000305 50.6 µM -2.14132999693015 0.0121748774661251 no 3296 0.0161237178727502 1073 5457690 SGTC_596 1155-0152 116 µM -2.16059912058341 0.0115353486076859 no 3297 0.0153631597097465 1072 280313 SGTC_1711 st032263 62.8 µM -2.19081824474826 0.0105911402853811 no 3298 0.0142324738989478 1072 3958979 SGTC_439 amiodarone 34.4 µM -2.20129302916508 0.0102799428403765 no 3299 0.0138576430231857 1067 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1 SGTC_1896 st058441 89 µM -2.22731470540884 0.00954113867604751 no 3300 0.0129631242008274 1065 688759 SGTC_1712 st032288 53.4 µM -2.24855926738419 0.00897281374415766 no 3301 0.0122702751885718 1077 2883011 SGTC_1847 st056231 15 µM -2.25603450597498 0.00878001335864697 no 3302 0.0120342351057853 1068 5393180 SGTC_1067 clotrimazole 1.36 µM -2.25771973978271 0.00873705304413449 no 3303 0.0119815688802315 1071 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_432 NS 1619 61.3 µM -2.27894511865923 0.00821154500634426 no 3304 0.0113351639498536 1064 4552 A K+/calcium channel activator. SGTC_3044 9093193 49.47 µM -2.28757627652166 0.00800592205840206 no 3305 0.0110811043764392 1070 25236277 SGTC_1853 st056710 91.2 µM -2.29210721633458 0.0078998026877063 no 3306 0.0109497285465829 1074 269167 SGTC_1189 1431-2119 7.28 µM -2.29303297727337 0.00787827324242814 no 3307 0.0109230532255987 1075 3107275 SGTC_2033 5192550 145 µM -2.29751848065405 0.00777468783037408 no 3308 0.0107946050251525 1069 182073 SGTC_1904 st060225 78 µM -2.29938068583249 0.00773203650840215 no 3309 0.0107416658568465 1060 66595 SGTC_627 1391-0720 175 µM -2.30533801422627 0.00759697182339902 no 3310 0.0105738250516944 1082 997839 SGTC_1714 st033236 13.627 µM -2.33720704797954 0.00690914135622094 no 3311 0.00971421044153418 1070 2916566 SGTC_1075 aripiprazole 15.2 µM -2.33816958150676 0.00688925137814455 no 3312 0.00968922640181564 1084 60795 An atypical antipschotic. YIL048W NEO1 SGTC_1469 k284-2957 126 µM -2.37229169368479 0.00621603866057322 no 3313 0.00883906410897232 1038 23884841 SGTC_2688 kanamycin b 96.69 µM -2.40116958953183 0.00569250923490452 no 3314 0.0081713802492196 1055 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis. SGTC_1452 4194-0072 190 µM -2.43044479238867 0.0052021035070676 no 3315 0.00754015165112044 1075 1343545 SGTC_2521 angolensin 13.4 µM -2.46007101482678 0.00474444830241989 no 3316 0.00694547632604663 1079 821428 A flavenoid. SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM -2.47377760311578 0.00454513420464919 no 3317 0.00668464461949154 1065 6857784 SGTC_194 1486-1323 56.904 µM -2.49609178145146 0.00423660756289286 no 3318 0.00627850533468007 1086 5178754 SGTC_2202 7226349 200 µM -2.52497668171205 0.00386509932643673 no 3319 0.00578529832241596 1078 844334 SGTC_2805 7950783 58.44 µM -2.54388213355437 0.00363802606124239 no 3320 0.0054814035082216 1072 1178958 YDL195W SEC31 SGTC_760 0568-0725 82.9 µM -2.54388974964516 0.00363793704929941 no 3321 0.00548128399797387 1079 3916171 SGTC_471 1-acyl-paf 4 µM -2.57133341511599 0.00332959995633547 no 3322 0.00506538705301717 1090 16759367 SGTC_2772 vinpocetine 57.06 µM -2.57911230345451 0.0032465837499478 no 3323 0.00495272890456923 1081 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor. SGTC_1197 1601-0112 267 µM -2.58623085108312 0.0031722511958813 no 3324 0.00485159593315125 1082 7350313 SGTC_458 nppb 133 µM -2.60165269875233 0.00301644356030898 no 3325 0.00463878763950224 1088 4549 A chloride channel blocker. SGTC_1701 st028638 40.4 µM -2.61281448388677 0.00290801285751455 no 3326 0.0044900016079488 1088 3490878 SGTC_904 1141-0088 396 µM -2.6228455934374 0.00281357773438388 no 3327 0.00435993906315874 1093 1378119 SGTC_872 0588-0139 234 µM -2.65171328035265 0.00255704978327136 no 3328 0.00400422580017136 1087 2047100 SGTC_1640 st009078 66.4 µM -2.68119754613808 0.00231704750066599 no 3329 0.00366795978372773 1088 690618 SGTC_1986 st071812 45 µM -2.69827060139103 0.0021875849603745 no 3330 0.00348503788539651 1088 11838594 SGTC_422 cantharidin 155 µM -2.83951493254073 0.0013433908946983 no 3331 0.00225910901791819 1082 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_1728 st035614 33.7865 µM -2.84205172583066 0.00133141760265336 no 3332 0.00224121091940335 1084 15945546 SGTC_1781 st038725 66.3 µM -2.86018738549906 0.00124862122641558 no 3333 0.00211695376732234 1091 4270275 YIL048W NEO1 SGTC_470 aa-861 153 µM -2.87323080715793 0.00119201491732982 no 3334 0.00203148582948712 1088 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor. SGTC_613 3914-0030 117 µM -2.90065681370323 0.00108057808117744 no 3335 0.00186190731696369 1079 1145395 SGTC_2279 7948423 32.93 µM -2.95603115498925 0.000884143996767294 yes 3336 0.00155812805680282 1089 1247112 SGTC_1253 0550-0034 176 µM -2.97474446117682 0.000825568395115666 yes 3337 0.00146616353564083 1089 5969915 SGTC_3311 9131146 2.8755 µM -2.99372033432516 0.00076983579248691 yes 3338 0.00137799217605925 1091 4900406 YPR165W RHO1 SGTC_778 3456-2434 196 µM -3.05304879513302 0.000617169865894358 yes 3339 0.00113264550152984 1003 5539063 SGTC_599 1935-0052 86.5 µM -3.05868252829708 0.00060423176431557 yes 3340 0.00111156301637801 1091 9557311 SGTC_1578 josamycin 24.2 µM -3.08094202200575 0.000555524340327855 yes 3341 0.00103173412039071 1091 5282165 A P450 substrate. SGTC_880 0833-0487 87.2 µM -3.11717580051484 0.00048393878246865 yes 3342 0.0009129632626315 1091 76075 SGTC_81 0411-0046 9.971 µM -3.14019400098024 0.000443005680628782 yes 3343 0.000844179935323043 1086 12925265 SGTC_445 e6 berbamine 66 µM -3.41057841215909 0.000150267081987706 yes 3344 0.000324126205774533 1087 6610268 A calcium/calmodulin antagonist. SGTC_1212 0520-0165 585 µM -3.4349419452755 0.000135786603213692 yes 3345 0.000296340392139237 1089 5403258 SGTC_870 0573-2213 57.6 µM -3.44607669842704 0.000129613713827152 yes 3346 0.000284394449846923 1093 3916321 SGTC_92 0063-0024 660.874 µM -3.56172680530591 7.93056026493333e-05 yes 3347 0.000184211821991333 1094 3594437 SGTC_568 1193-0097 7.48 µM -3.81426371836005 2.57812529863769e-05 yes 3348 6.82947746865777e-05 1081 3646150 SGTC_2849 9019321 12.99 µM -4.29978292583358 2.43960372161311e-06 yes 3349 8.54827437187417e-06 1088 16489627 SGTC_2801 7907800 81.82 µM -4.41753918106461 1.32396522821024e-06 yes 3350 4.99154889951801e-06 1092 6620925 SGTC_94 0334-0113 514.748 µM -4.58726038303228 5.33965848050035e-07 yes 3351 2.24550209113455e-06 1095 6795178 SGTC_2403 6032726 181.2 µM -5.18457474101033 1.69256530941687e-08 yes 3352 1.08254154250658e-07 1094 2881040