SGTCid condition conc unit PBP1|YGR178C.score PBP1|YGR178C.strain.pval PBP1|YGR178C.strain.significant PBP1|YGR178C.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene
SGTC_1934 st074720 32.6 µM 13.4291717807947 1.03899138189259e-36 yes 1 2.03974219637542e-41 2 17250992
SGTC_15 0266-0086 27.098 µM 11.0152060986759 2.35919651691169e-25 yes 2 1.61398505062835e-28 3 1712902 YIL048W NEO1
SGTC_1754 st042065 16.137 µM 8.1677066802186 8.64192404165005e-15 yes 3 1.57153488141248e-16 53 1126236 YIL048W NEO1
SGTC_43 0570-0105 72.5 µM 7.39381836127516 1.90627086003888e-12 yes 4 7.13356379797833e-14 20 1114046 YDL195W SEC31
SGTC_1495 4469-0029 237 µM 6.19550888599131 2.92983228514858e-09 yes 5 2.90485072918991e-10 48 793680
SGTC_1803 st050068 52.4 µM 6.11939821886465 4.47879677956568e-09 yes 6 4.69647014434952e-10 79 3984059 YIL048W | YNL267W NEO1 | PIK1
SGTC_207 4185-0010 4.486 µM 5.66559727020157 5.07559495703073e-08 yes 7 7.32566403048499e-09 47 3761753
SGTC_1908 st060353 56.5 µM 5.65952471452513 5.23694080404084e-08 yes 8 7.5896394756852e-09 11 4227716
SGTC_1800 st050079 29.0735 µM 5.37370336564749 2.20458185420481e-07 yes 9 3.85678583094299e-08 62 3645560
SGTC_398 bronopol 33.3 µM 5.31313584267473 2.96300098662749e-07 yes 10 5.38773248114519e-08 12 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them.
SGTC_1801 st050089 28.441 µM 5.29291947780747 3.26805883273592e-07 yes 11 6.01894667892684e-08 63 5008493 YIL048W | YNL267W NEO1 | PIK1
SGTC_528 3492-0019 172 µM 5.04984819114382 1.03320903492185e-06 yes 12 2.21080653147152e-07 154 2869262
SGTC_2066 5222451 176 µM 5.04497312881019 1.05679704611524e-06 yes 13 2.26792554576319e-07 13 2281147
SGTC_1592 4',5'-dihydroxyflavone 8.85 µM 4.85119713021187 2.55025704376884e-06 yes 14 6.13592488381845e-07 3 688669
SGTC_2835 9006588 71.43 µM 4.84595756929297 2.6105825176603e-06 yes 15 6.30012229114746e-07 21 2345538
SGTC_1094 duloxetine 25.4 µM 4.79563933709277 3.26387487083183e-06 yes 16 8.1078403579357e-07 4 60834 A selective serotonin reuptake inhibitor.
SGTC_2550 chrysin dimethyl ether 71.87 µM 4.78728081851679 3.38653719637428e-06 yes 17 8.45281034058579e-07 3 88881 An O-methylated flavonoid and antioxidant.
SGTC_2562 3',7'-dimethoxyflavone 64.92 µM 4.76014828823644 3.81583252797974e-06 yes 18 9.67253863852247e-07 12 688664
SGTC_143 4032-1194 15.74 µM 4.7215910322772 4.51631299589308e-06 yes 19 1.17003426211877e-06 35 1806963
SGTC_445 e6 berbamine 66 µM 4.68921146377252 5.19793148247137e-06 yes 20 1.37129927409634e-06 74 6610268 A calcium/calmodulin antagonist.
SGTC_2424 5537928 59.2 µM 4.68835225621075 5.21729289365321e-06 yes 21 1.37706822503321e-06 21 5382802
SGTC_1469 k284-2957 126 µM 4.6497408672496 6.16207102595956e-06 yes 22 1.66176168972805e-06 4 23884841
SGTC_1760 st045453 10.4495 µM 4.56591112717447 8.80602073786959e-06 yes 23 2.4866472494025e-06 121 3323419 YIL048W NEO1
SGTC_1712 st032288 53.4 µM 4.45890484145113 1.37710705218004e-05 yes 24 4.11897407473305e-06 151 2883011
SGTC_2582 agaric acid 100 µM 4.45244585889858 1.41434451686656e-05 yes 25 4.24488254151459e-06 263 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase.
SGTC_2082 5219693 150 µM 4.43019934022311 1.55006267195665e-05 yes 26 4.70730109411984e-06 17 2834649
SGTC_628 1636-0253 16 µM 4.40513847247908 1.71775517195213e-05 yes 27 5.28581627478025e-06 26 4456143
SGTC_3037 9091026 49.47 µM 4.35395510452453 2.11525924509017e-05 yes 28 6.68515500306788e-06 101 25236398 YIL048W NEO1
SGTC_2038 4100038 30.985 µM 4.35303080572275 2.12318267399572e-05 yes 29 6.71341372999348e-06 37 3596803
SGTC_90 0870-0863 4.608 µM 4.31720349668303 2.45294063913205e-05 yes 30 7.90092317251818e-06 37 1738164
SGTC_649 1123-0311 367 µM 4.22511003629593 3.53761833793261e-05 yes 31 1.19412026883853e-05 59 693629 YIL048W NEO1
SGTC_2581 avocatin a 64 µM 4.11665381677423 5.39554965027e-05 yes 32 1.92206404668607e-05 47 6710728 A skin care supplement.
SGTC_3251 9135047 49.47 µM 4.06302340991813 6.6238426585804e-05 yes 33 2.4220584660945e-05 2 17682963
SGTC_2997 9067075 71.4286 µM 4.01387821862544 7.97662808262186e-05 yes 34 2.98645857684443e-05 52 27209819
SGTC_1497 4476-2978 41.3 µM 3.94190221007126 0.000104338484893345 yes 35 4.04189683281217e-05 8 1528379
SGTC_196 k015-0023 18.111 µM 3.91424036719842 0.000115549335016216 yes 36 4.53446302487761e-05 22 5211998
SGTC_2541 muurolladie-3-one 83.07 µM 3.81673564742974 0.000164738900671099 yes 37 6.76144600396254e-05 34 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils. YMR203W TOM40
SGTC_14 0354-0009 295 µM 3.77863754926643 0.000188819960654744 yes 38 7.8844371951178e-05 31 1713507
SGTC_1107 amlodipine 47 µM 3.77803640744067 0.00018922505088595 yes 39 7.90348872831901e-05 45 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.
SGTC_2752 diclazuril 33.15 µM 3.76313562755371 0.000199529630666797 yes 40 8.38980700565429e-05 134 456389 An antifungal agent for coccidioides. YHR062C RPP1
SGTC_1916 st067606 49.2 µM 3.71860690463341 0.000233533320327461 yes 41 0.0001001622552765 47 19590279
SGTC_3303 9125618 40.5795 µM 3.67064477701989 0.000276160561450746 yes 42 0.000120969691965537 57 22695467
SGTC_1932 st074806 40.9 µM 3.65696025940659 0.000289590888494784 yes 43 0.000127611965644246 34 17251235
SGTC_221 trifluoperazine 10.304 µM 3.65624449010746 0.000290309829441538 yes 44 0.000127968633314806 226 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1
SGTC_2126 5251174 33.877 µM 3.6507854192484 0.000295848005520579 yes 45 0.000130719799584053 50 790722
SGTC_2186 6124449 200 µM 3.63811212095267 0.000309086329092832 yes 46 0.000137321932738288 26 3834182 YLR033W RSC58
SGTC_198 3454-2873 16.191 µM 3.62292113734451 0.000325680459063662 yes 47 0.000145647327324918 22 710957
SGTC_1567 st069303 68.4 µM 3.62158664675851 0.000327177121572166 yes 48 0.000146400851371259 28 5581319
SGTC_146 3448-8650 53.125 µM 3.60596722209439 0.000345176736952303 yes 49 0.000155496196630045 165 2891488 YIL048W NEO1
SGTC_1406 3909-7906 11.9 µM 3.54168737883991 0.000429376443570315 yes 50 0.000198788182854633 18 X1406
SGTC_2858 9025781 8.96 µM 3.53617823837932 0.000437415236186909 yes 51 0.000202980347498319 121 4894980 YPL153C RAD53
SGTC_722 3534-0461 190 µM 3.53186292311639 0.000443809244172712 yes 52 0.000206321598578819 50 658262
SGTC_2275 7947463 200 µM 3.50631843338458 0.000483467193679142 yes 53 0.000227175650267044 51 1225414
SGTC_635 k038-0028 24.7 µM 3.46686316599029 0.000551214671249824 yes 54 0.000263284936697649 61 4035102
SGTC_976 1348-1067 47.6 µM 3.45719642078553 0.00056910160650361 yes 55 0.000272913423112373 51 5310671 YGL099W LSG1
SGTC_919 tnp00227 403.569 nM 3.45268028479022 0.000577640637752632 yes 56 0.000277523217658257 62 1269246 A methoxyflavone. YNL221C POP1
SGTC_1055 3448-0672 86 µM 3.43142249268607 0.000619447993890559 yes 57 0.000300212339992435 53 748378
SGTC_2113 5491891 107.031 µM 3.42692494822249 0.00062864395384693 yes 58 0.000305228883661861 43 789979
SGTC_1687 st020778 55.3625 µM 3.40781711751774 0.000669135632280339 yes 59 0.000327423839186701 202 4259299
SGTC_2131 toluylene red 5.2905 µM 3.38484864912525 0.000720988572190912 yes 60 0.000356087556324931 46 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain.
SGTC_854 0422-0053 192 µM 3.38477831953127 0.000721152883844328 yes 61 0.000356178799506149 29 3596728
SGTC_1855 st056195 39.6 µM 3.35933243183717 0.000782920064628843 yes 62 0.000390655092559293 39 4028379
SGTC_664 1222-0054 14.9 µM 3.34942373236623 0.0008082631554829 yes 63 0.000404899233095316 54 6813991
SGTC_2688 kanamycin b 96.69 µM 3.31827189238704 0.000892938800558133 yes 64 0.000452881349451648 473 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis.
SGTC_1377 2944-0135 198 µM 3.29854936241081 0.000950685765437175 yes 65 0.000485928955376062 65 1894137
SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM 3.26944928182898 0.00104217263223635 no 66 0.000538785266298754 28 803109
SGTC_2987 9018338 71.43 µM 3.24863771109403 0.00111248011474054 no 67 0.000579795319283608 50 5055682
SGTC_2518 prenyletin 46.28 µM 3.21821406506778 0.00122310265017934 no 68 0.000644957548803726 24 3873459 A coumarin with calcium channel inhibitory activity.
SGTC_2777 climbazole 1.536 µM 3.19231145791572 0.00132512389186853 no 69 0.00070569526870093 87 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2
SGTC_439 amiodarone 34.4 µM 3.19002802182775 0.00133448065567838 no 70 0.000711294996287043 134 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1
SGTC_2536 dehydroabietamide 32.04 µM 3.18177384080999 0.00136880940131339 no 71 0.000731880357665611 74 3983547
SGTC_2398 5228213 48.84 µM 3.12831568768568 0.00161138219446281 no 72 0.000879056190442366 90 80771 YMR134W ERG29
SGTC_1002 4049-0206 172 µM 3.12063729309953 0.00164927350300434 no 73 0.000902300772811828 80 4662749
SGTC_1524 corynanthine 62.1 µM 3.11514189382104 0.00167688854014374 no 74 0.000919282216643843 56 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist.
SGTC_2531 methyl deoxycholate 70.07 µM 3.11186719390586 0.00169354385021182 no 75 0.000929540562395767 62 16667744 Haematoxylin.
SGTC_2393 9031399 185.94 µM 3.0981218961839 0.00176510866599915 no 76 0.00097375653024125 70 1526623 YDL150W RPC53
SGTC_1605 st000082 49.1 µM 3.046652450039 0.00205819160845878 no 77 0.00115702550425201 60 1114022
SGTC_3349 9149703 23.001 µM 3.0105029239279 0.00228972535501117 no 78 0.00130407718410858 48 4910494
SGTC_2312 7706453 155.7 µM 2.98598707257529 0.00245991001496914 no 79 0.00141332296098514 74 976098
SGTC_7 0192-1582 4.227 µM 2.98385484166193 0.00247523936717456 no 80 0.00142320887080462 136 252616
SGTC_1930 st074634 34.3 µM 2.97160682782892 0.00256498014322032 no 81 0.00148122895577029 84 684253 YOR116C RPO31
SGTC_3249 9135183 49.47 µM 2.9655827851034 0.00261018803824232 no 82 0.0015105501198613 59 4902779
SGTC_2983 9022671 12.99 µM 2.94869359058994 0.00274079813321554 no 83 0.00159560100262606 47 6405161
SGTC_2116 5511452 16.8835 µM 2.93434932658691 0.00285632882987054 no 84 0.00167123896061369 55 870744
SGTC_70 0141-0289 43.283 µM 2.91204587105024 0.00304470427645692 no 85 0.00179534950368737 298 352408
SGTC_1230 0170-0365 3.77 µM 2.90574382910383 0.00309992194251586 no 86 0.00183190633852645 157 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1
SGTC_1188 1403-0014 4.57 µM 2.90336459321904 0.00312100185282541 no 87 0.00184588287973619 121 9614867
SGTC_1496 4469-0713 57.4 µM 2.89921150797852 0.00315810741169723 no 88 0.00187051219447934 66 746691
SGTC_2215 7188065 200 µM 2.86992773403396 0.00343121048385172 no 89 0.00205282809858417 35 940217
SGTC_2021 4019055 173 µM 2.86714117105176 0.00345827312335636 no 90 0.00207099103509339 229 44827708 YER133W GLC7
SGTC_2823 7987624 58.44 µM 2.86430701849875 0.0034859944791897 no 91 0.00208961361532453 101 2239440
SGTC_1039 k821-0043 94 µM 2.8529281515739 0.00359931337756343 no 92 0.00216592071960964 83 15992768
SGTC_3155 9099265 49.47 µM 2.85133583610104 0.00361543176183462 no 93 0.00217679802205321 81 25236499
SGTC_2827 7993847 71.43 µM 2.82990252161882 0.00383878559025696 no 94 0.00232810940511958 70 2985692
SGTC_1102 cgs 12066b 26.1 µM 2.81309011718007 0.00402255707569303 no 95 0.00245339488305545 42 6438352 A 5-HT1B full agonist.
SGTC_3152 9099253 49.47 µM 2.81289435691966 0.00402474248989042 no 96 0.00245488893157782 234 25236131
SGTC_607 4491-0986 66.8 µM 2.77247513208071 0.00449940014261458 no 97 0.00278158849389671 84 698981 YDR232W HEM1
SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM 2.76279884271769 0.00462019944450696 no 98 0.00286540366058077 109 4174840
SGTC_2003 4023581 200 µM 2.75556615453737 0.00471237428535926 no 99 0.00292953273921082 99 16641307
SGTC_1367 1812-0510 76.9 µM 2.74881161982179 0.00479993300019524 no 100 0.00299058751942822 95 1142582 YDR527W RBA50
SGTC_1919 st067113 52.3 µM 2.72828343584322 0.00507500906611517 no 101 0.00318324393153872 105 1268243
SGTC_2351 9026858 72.31 µM 2.72429012395894 0.00513012144960074 no 102 0.00322199359804707 90 1409300
SGTC_1941 st076221 61.8 µM 2.71872664835273 0.00520779194123678 no 103 0.0032766870548314 170 2828568
SGTC_1818 st052136 56.3 µM 2.70317950172242 0.00543041831243621 no 104 0.0034339822915334 142 674169
SGTC_658 3253-0951 102 µM 2.70067081390649 0.00546712323275144 no 105 0.00345998962234731 147 1184878
SGTC_2205 7238770 200 µM 2.6936245636975 0.00557139979083671 no 106 0.00353398646967921 50 279867
SGTC_3069 9117009 49.47 µM 2.68109236518265 0.00576123418661968 no 107 0.00366911290750166 46 41904981
SGTC_2362 9071156 126 µM 2.67927065089768 0.00578930166702865 no 108 0.00368913645819272 75 653133
SGTC_1877 wortmannin 25 µM 2.67569422527424 0.00584475744556086 no 109 0.00372873244630426 181 312145 A covalent inhibitor of PI 3-kinase.
SGTC_610 4215-0184 155 µM 2.67473943306015 0.00585964185194697 no 110 0.00373936757871525 83 5605015
SGTC_1049 3226-0134 66 µM 2.66191640025482 0.00606282510787928 no 111 0.00388485865174086 127 5702385
SGTC_1407 3909-7909 12.3 µM 2.65328940283129 0.00620301139524817 no 112 0.0039855747325374 76 4411780
SGTC_2381 9035592 200 µM 2.6481567466273 0.00628777104047676 no 113 0.0040465995274151 89 4749657
SGTC_699 0375-0592 111 µM 2.63211976493582 0.00655924673514457 no 114 0.0042426972517229 82 762578
SGTC_1705 st027868 56.3335 µM 2.62213562683275 0.00673344804210191 no 115 0.00436903248268848 74 292948
SGTC_108 0509-0257 621.132 µM 2.61829604269206 0.00680152112403456 no 116 0.00441850507880385 144 536624
SGTC_293 4049-0273 38.5 µM 2.61816141131837 0.00680391903533082 no 117 0.00442024883429594 66 1380311
SGTC_1333 1482-0047 286 µM 2.60597714950888 0.0070240483773285 no 118 0.00458062865867323 105 3811116
SGTC_232 clozapine 119 µM 2.59736692956928 0.00718337410203673 no 119 0.00469707559967827 147 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_2629 bisabolol 100 µM 2.58935138291869 0.00733455209488555 no 120 0.00480784595681456 112 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer.
SGTC_748 act1.228 77.9 µM 2.57542282392673 0.00760393254398946 no 121 0.00500588066877833 184 4421505 YNR035C ARC35
SGTC_481 bay k-8644 50 µM 2.57380807648755 0.00763571872301074 no 122 0.00502930261742515 96 2303 A calcium channel antagonist.
SGTC_96 0929-0093 37.281 µM 2.57100759136904 0.00769112350868499 no 123 0.00507015520685969 83 6991579
SGTC_1071 trifluoperazine 6.31 µM 2.56716201494161 0.00776778085338928 no 124 0.00512673462836532 103 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels.
SGTC_531 3788-1495 174 µM 2.56629157943243 0.0077852250583018 no 125 0.00513961896152022 121 2896655
SGTC_3185 9108267 49.47 µM 2.55914867343022 0.00792968128953271 no 126 0.00524644279430791 120 4910486
SGTC_3011 9081274 71.4286 µM 2.55820373622413 0.00794896691770734 no 127 0.00526072148392653 108 6625322
SGTC_1186 1319-0216 26 µM 2.55080598410782 0.0081013815737241 no 128 0.0053737068143562 109 4565136
SGTC_2620 irigenin 100 µM 2.54600227147327 0.00820172161967673 no 129 0.00544822396536119 130 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro.
SGTC_2938 9059746 27.26 µM 2.54157350997848 0.0082951952809324 no 130 0.00551773689498327 134 6471769
SGTC_1663 st014140 55.4 µM 2.53932373946265 0.00834303640741901 no 131 0.00555334974422866 114 4207120
SGTC_1498 4478-3555 97.6 µM 2.51180199478715 0.00894818724735113 no 132 0.00600582314956195 48 3437919
SGTC_3206 9114350 49.47 µM 2.49927293364638 0.00923618715894035 no 133 0.00622242115158048 103 17087243
SGTC_730 1436-0052 41.2 µM 2.48645115771971 0.00953928242774254 no 134 0.00645121396369826 88 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2
SGTC_355 1311-2252 105 µM 2.4721861948668 0.00988667911929118 no 135 0.00671447767024606 125 5338538
SGTC_2291 7917025 104.35 µM 2.43522616617334 0.0108386252758387 no 136 0.00744124216954425 181 2964612
SGTC_275 trichlorophene 5.69 µM 2.4320480677704 0.0109240879008744 no 137 0.00750685734748971 357 62616
SGTC_3263 9137018 49.47 µM 2.42988885577576 0.0109824855193236 no 138 0.00755172679946378 117 43844957
SGTC_2784 7567673 72.73 µM 2.42911381793167 0.011003513180426 no 139 0.00756788996750227 166 3471247
SGTC_3032 9089427 49.47 µM 2.41664037676695 0.0113467812192341 no 140 0.00783224242559658 110 17173707
SGTC_2755 lomerizine 42.69 µM 2.41180472917969 0.0114823397685584 no 141 0.00793689031074533 142 3949 A calcium channel blocker.
SGTC_1564 D-Arginine 115 µM 2.4115908637402 0.0114883674416149 no 142 0.00794154681671536 146 71070 D-isomer of arginine; arginine decarboxylase inhibitor.
SGTC_2130 NSC 7 2.4545 µM 2.39841177783599 0.0118651546211633 no 143 0.0082331712720679 169 21448
SGTC_502 l-744,832 89.3 µM 2.39390563768194 0.0119964209759908 no 144 0.00833501844920603 152 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.
SGTC_328 k915-0120 63.5 µM 2.39007513635726 0.0121089940490458 no 145 0.00842246312488224 127 6624543
SGTC_840 0245-0196 390 µM 2.38349391260725 0.0123045459800823 no 146 0.00857458404733584 131 3827528
SGTC_1530 rhein 70.4 µM 2.37984081132937 0.0124142691872075 no 147 0.00866005923271124 139 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death.
SGTC_1471 k673-0312 37 µM 2.3676207905982 0.0127874860223644 no 148 0.00895143748947889 107 24099884
SGTC_1528 arabinosylhypoxanthine 74.6 µM 2.35816609257184 0.0130828691535546 no 149 0.00918273686563497 158 804 An inhibitor of viral and cellular DNA polymerases.
SGTC_920 mycophenolic acid 780.421 nM 2.35231721917793 0.0132685368165688 no 150 0.00932842826167823 161 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_97 0535-0701 19.132 µM 2.34994410250042 0.0133445160797025 no 151 0.00938811526286319 127 2832013 YGL099W LSG1
SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM 2.34743835805878 0.0134251491961169 no 152 0.00945150034602533 144 6708514
SGTC_1128 3448-9350 235 µM 2.34391659945919 0.0135391878922194 no 153 0.00954121894753549 150 619386
SGTC_1051 3253-3903 78 µM 2.34017734293782 0.0136611836602321 no 154 0.00963729250788752 162 5509239
SGTC_3074 9116018 49.47 µM 2.33976161956106 0.0136748053246096 no 155 0.00964802582864062 116 17027303
SGTC_2697 mebhydrolin 72.4 µM 2.33566572891983 0.0138096396813482 no 156 0.0097543349876891 218 22530 H1 Histamine receptor antagonist. YIL048W NEO1
SGTC_2063 5246145 200 µM 2.33497214820029 0.0138325851171763 no 157 0.00977243788342839 155 711240
SGTC_2624 nerol 100 µM 2.32429686453769 0.0141899203312309 no 158 0.0100547943765061 115 637566 A natural product oil.
SGTC_2034 5197015 53.07 µM 2.31509203627515 0.0145043920194094 no 159 0.0103039478829002 131 780676
SGTC_2524 avocatin b 10.57 µM 2.29971844588273 0.0150429914125839 no 160 0.0107320881986296 118 6710748
SGTC_934 2950-0684 338 µM 2.29827697778235 0.0150943622173754 no 161 0.0107730149528117 154 1121253
SGTC_1770 st043884 66.3 µM 2.29447604411788 0.0152305426582351 no 162 0.010881584777974 138 670149
SGTC_900 1112-0045 141 µM 2.28982401850212 0.0153986512763464 no 163 0.0110157601163119 121 56211 YIL048W NEO1
SGTC_1129 3453-1384 223 µM 2.25294588999887 0.016788557892296 no 164 0.0121312804590415 195 1084452
SGTC_178 4092-0806 87.505 µM 2.24957032761384 0.0169209805288671 no 165 0.0122381169008774 291 2169044
SGTC_8 0354-0001 70 µM 2.21825764366352 0.0181925071179712 no 166 0.0132686352003416 271 4993152
SGTC_1075 aripiprazole 15.2 µM 2.216772287261 0.018254794332683 no 167 0.013319328084053 206 60795 An atypical antipschotic. YIL048W NEO1
SGTC_763 3453-1109 128 µM 2.21077532977545 0.0185081229686843 no 168 0.0135256995150372 163 1560353
SGTC_1304 1165-0502 251 µM 2.20445125421595 0.0187785068401203 no 169 0.0137463122523451 220 767425
SGTC_1098 clofazimine 15.1 µM 2.20425149302141 0.0187871020445455 no 170 0.0137533311179471 205 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2
SGTC_1122 capsaicin 818.572 nM 2.20363878701369 0.018813486073444 no 171 0.0137748786149627 168 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_1006 4099-6547 255 µM 2.20001423612684 0.0189702103347359 no 172 0.0139029425006035 176 3146833
SGTC_2659 sanguinarine 24.21 µM 2.1954407443466 0.0191695498008689 no 173 0.0140659985498222 163 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis.
SGTC_1615 st002656 86.5 µM 2.19346181331126 0.0192563535270078 no 174 0.0141370614909139 154 1584458
SGTC_955 1216-0110 33 µM 2.18820010395073 0.0194887794029541 no 175 0.0143275147740884 248 3619719
SGTC_2891 9063876 19.48 µM 2.18755064219623 0.0195176326688786 no 176 0.0143511752544052 86 6472478
SGTC_2778 tioconazole 65.09 nM 2.18602828925805 0.0195854076006724 no 177 0.014406767857297 242 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_547 1120-0019 610 nM 2.17910022333476 0.0198963738944525 no 178 0.0146621118412701 197 3676939
SGTC_579 4491-1009 110 µM 2.17675897647859 0.0200024035260523 no 179 0.0147492776856802 233 1271041
SGTC_3203 9113543 49.47 µM 2.17545770128984 0.020061542233693 no 180 0.0147979172828699 190 17018012
SGTC_1422 4031-0024 15.5 µM 2.17213117597239 0.0202133964694207 no 181 0.0149228850253385 140 782427
SGTC_1506 4226-2149 212 µM 2.1596328026996 0.0207926799280521 no 182 0.0154005534746949 214 991114
SGTC_3127 9126946 49.47 µM 2.15262053586112 0.0211238017751375 no 183 0.0156742566276065 144 27243249
SGTC_2387 9077560 195.08 µM 2.14775107391932 0.0213563550168355 no 184 0.0158667678161851 167 5303272
SGTC_403 arphamenine a 50 µM 2.14683421745519 0.0214003830723677 no 185 0.0159032410865119 190 5487158 An arginine aminopeptidase inhibitor.
SGTC_1492 4158-0558 28.5 µM 2.14645284852493 0.0214187192469094 no 186 0.0159184333981603 172 3967268
SGTC_1282 0886-0010 32.4 µM 2.13691086003364 0.0218818389115791 no 187 0.0163026212657777 203 2836211 YNL267W PIK1
SGTC_3150 9097574 49.47 µM 2.13555691926386 0.0219482324418948 no 188 0.016357773035323 142 17217476
SGTC_2389 9091542 195.52 µM 2.13166468940886 0.0221400446974005 no 189 0.0165172108033206 205 3626624 YOL127W RPL25
SGTC_2505 galangin 7.89 µM 2.12809689869733 0.0223171091965282 no 190 0.0166645252033972 129 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_1817 st052116 64.4 µM 2.1226501242539 0.0225897281808551 no 191 0.0168915906756952 164 4361398
SGTC_18 0111-0177 500 nM 2.12160168620742 0.0226425249739144 no 192 0.0169356003380711 285 721752
SGTC_1408 3909-7976 48.8 µM 2.12053371733898 0.0226964121956343 no 193 0.0169805305933611 210 24152374
SGTC_3219 9131112 49.47 µM 2.12022398382978 0.022712060832816 no 194 0.0169935803635792 190 17612988 YMR079W SEC14
SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM 2.10306461736733 0.0235933195976026 no 195 0.0177300606947602 231 6708561
SGTC_136 0097-0015 404.482 µM 2.08528475821885 0.0245366074184188 no 196 0.0185217300590091 207 4861337
SGTC_957 1187-1561 14.1 µM 2.07956980243918 0.0248464495348141 no 197 0.0187825045871178 209 1538454
SGTC_2967 9089538 49.85 µM 2.07185594531026 0.0252698619519513 no 198 0.0191394387403285 223 728216
SGTC_755 1995-0008 37.3 µM 2.07145480979879 0.0252920445839591 no 199 0.0191581566872356 181 689533
SGTC_2569 tetrandrine 100 µM 2.07119208207495 0.0253065821612921 no 200 0.0191704246264663 184 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_725 1497-0963 19 µM 2.07112486119796 0.0253103028350274 no 201 0.0191735645442902 168 3549977
SGTC_2546 rhodinyl acetate 100 µM 2.07075709834574 0.0253306666122968 no 202 0.0191907506546712 188 6708682
SGTC_2533 agelasine 13.65 µM 2.06765288212749 0.0255031008706782 no 203 0.0193363377754108 243 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase.
SGTC_69 0096-0274 206.684 µM 2.0663912224104 0.0255734644610949 no 204 0.0193957770365815 278 6741392
SGTC_194 1486-1323 56.904 µM 2.0609344403823 0.02587966731919 no 205 0.0196546475249742 186 5178754
SGTC_1505 k297-0037 20.6 µM 2.05853681991232 0.0260151746771654 no 206 0.0197693152804474 207 4089396
SGTC_2809 7964133 12.99 µM 2.0547270597244 0.0262317130370169 no 207 0.0199526873902871 255 1253665
SGTC_1982 st072467 71.9 µM 2.05066326166972 0.0264643492387738 no 208 0.0201498755233965 258 3163533
SGTC_892 0929-0076 29 µM 2.0468968721495 0.0266814969297458 no 209 0.0203341056400271 280 5751038
SGTC_1793 st048256 72.231 µM 2.04443399178305 0.0268242952015572 no 210 0.0204553460661138 137 672022
SGTC_2242 6630449 61.2675 µM 2.04353444080808 0.0268766101871526 no 211 0.0204997808044209 213 691249 YDR170C SEC7
SGTC_2249 haloperidol 116.36 µM 2.04233867985522 0.0269462836377522 no 212 0.0205589738939079 369 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_1207 2099-0101 141 µM 2.03124866366032 0.027599677665607 no 213 0.021114888063627 223 5837381
SGTC_2108 5365811 200 µM 2.02943262701769 0.0277079219198677 no 214 0.0212071223623056 214 780283
SGTC_444 curcumin 90.4 µM 2.02623721339747 0.0278992423336182 no 215 0.0213702409349763 221 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties.
SGTC_953 1188-0045 9.7 µM 2.02403721084484 0.0280316026774186 no 216 0.0214831616039719 239 6144426
SGTC_930 2810-3379 265 µM 2.01608181083019 0.0285146010152711 no 217 0.0218957108574338 231 1015764
SGTC_1962 st076595 64.5 µM 2.01360777361057 0.0286662118230092 no 218 0.0220253648201036 226 279619
SGTC_3166 9102297 49.47 µM 2.0134003707206 0.0286789520216959 no 219 0.0220362633224231 245 25237072
SGTC_278 4092-0821 23.9 µM 1.99127963166346 0.0300650547012723 no 220 0.0232250767242207 219 877900
SGTC_191 3914-0123 66.505 µM 1.98139876240447 0.0307019064317648 no 221 0.0237732862251365 102 3144412
SGTC_350 k064-0020 19.8 µM 1.98122551606116 0.0307131715584221 no 222 0.0237829944854839 258 2790705
SGTC_605 1315-0399 119 µM 1.97678573817953 0.0310030322522258 no 223 0.0240329272284576 250 24020461
SGTC_3047 9092122 49.47 µM 1.96421434903509 0.0318360842932262 no 224 0.024752619735663 229 17173831
SGTC_990 3985-0011 41.3 µM 1.96123183926047 0.0320364129652149 no 225 0.0249259921531696 193 5399565 YGL099W LSG1
SGTC_3059 1327-0034 3 µM 1.96085962242263 0.0320614868556259 no 226 0.0249477003057701 268 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_1500 4488-1866 171 µM 1.95259707230624 0.032622267480758 no 227 0.0254336791781138 234 2900003
SGTC_2475 5812728 15.03 µM 1.95173906276873 0.0326809615395486 no 228 0.0254845961694813 248 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2
SGTC_2993 9054257 71.4286 µM 1.94716696798185 0.0329951960086933 no 229 0.0257573602187497 308 6470217 YGL055W OLE1
SGTC_1575 cyproterone acetate 48 µM 1.93924157945216 0.0335457950877832 no 230 0.0262359644090551 247 9880 An androgen receptor antagonist and liver toxin.
SGTC_3117 9124945 49.47 µM 1.93250154646291 0.0340199747785864 no 231 0.0266488156810364 182 17592065
SGTC_2847 9005661 71.43 µM 1.92247626699429 0.0347354650290417 no 232 0.0272729285448669 126 2991449
SGTC_2867 9039098 71.43 µM 1.92099000690953 0.0348425816063119 no 233 0.0273664836687844 273 6463460
SGTC_1579 chlormadinone acetate 49.4 µM 1.91738178478153 0.0351037592532062 no 234 0.0275947233056037 237 45114258 A steroidal progestin.
SGTC_873 0591-4978 488 µM 1.91072305461909 0.0355899620949669 no 235 0.0280200902240575 246 3305145
SGTC_1619 st003326 88.7 µM 1.90953794880919 0.0356770713798058 no 236 0.0280963655646291 192 2849032
SGTC_848 0368-0089 85.6 µM 1.90933545914381 0.0356919725198864 no 237 0.0281094154070432 248 762535
SGTC_2745 rifampicin 24.3 µM 1.90694934740054 0.0358679501055494 no 238 0.0282635735244651 122 25141428 Inhibits bacterial DNA-dependent RNA polymerase.
SGTC_3182 9108849 49.47 µM 1.90481134911471 0.0360262323570902 no 239 0.0284022990448001 282 17133045
SGTC_1636 st007707 68.9 µM 1.9033304195772 0.0361362049092308 no 240 0.0284987219689666 298 403051
SGTC_3209 9113616 49.47 µM 1.90164137073615 0.036261967608468 no 241 0.0286090277482647 257 16649353
SGTC_683 panaxydol 45 µM 1.89681984713816 0.0366229395870019 no 242 0.0289258594727615 257 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis.
SGTC_2267 7931562 200 µM 1.8965766630773 0.0366412235876762 no 243 0.0289419165218135 225 934880
SGTC_828 2074-0507 139 µM 1.89132563714947 0.0370378511772995 no 244 0.0292904442219131 271 X828
SGTC_1343 1487-0095 224 µM 1.88813974632643 0.0372801979284603 no 245 0.0295035960997681 217 4560101 YGL055W OLE1
SGTC_2675 theaflavin digallate 100 µM 1.88743348602556 0.0373340973249607 no 246 0.0295510223668773 261 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative.
SGTC_3257 9139206 32.98 µM 1.88014438075306 0.0378941043802241 no 247 0.0300442016770004 166 4910041
SGTC_2666 tannic acid 100 µM 1.87907453036265 0.0379768727068341 no 248 0.0301171586481103 287 16134267 A thiamine antagonist.
SGTC_1456 k015-0012 13 µM 1.86695466762784 0.0389248572276253 no 249 0.0309539593297404 306 2989616
SGTC_2878 9043973 25.97 µM 1.86546933383437 0.0390423504103371 no 250 0.0310578233848772 222 6465167
SGTC_2615 purpurogallin-4-carboxylic acid 100 µM 1.85406413795396 0.0399541773076942 no 251 0.0318649922899948 325 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase.
SGTC_3302 9125395 16.351 µM 1.8491252597631 0.0403543665113276 no 252 0.0322198638666097 240 17599668
SGTC_695 3505-6186 243 µM 1.84582715527543 0.0406234146485238 no 253 0.0324586531674317 257 1819379
SGTC_27 0485-0001 32.618 µM 1.83790516127448 0.0412756150688605 no 254 0.0330381907251818 168 2054479
SGTC_734 2023-0417 80 µM 1.83520982964953 0.0414994415467938 no 255 0.0332373026286619 272 3935732
SGTC_747 3448-8087 38.7 µM 1.8351748129587 0.0415023558711492 no 256 0.0332398959018769 291 5168703
SGTC_841 0251-0215 91.2 µM 1.83449576844002 0.0415589033152221 no 257 0.0332902176791276 344 3888614
SGTC_954 1189-0853 2.85 µM 1.83382940765377 0.0416144551891014 no 258 0.0333396604845642 294 2828194
SGTC_418 lividomycin a 100 µM 1.82559084407976 0.042306253489572 no 259 0.0339559579950152 251 72394 An antibiotic.
SGTC_1655 st012546 55.1 µM 1.82531303494687 0.0423297425159357 no 260 0.0339769021244274 261 720985 YLR208W SEC13
SGTC_2276 7947513 42.08 µM 1.81355486516802 0.0433336186941254 no 261 0.0348731422770901 267 2105100
SGTC_313 3474-0040 5.03 µM 1.81070777457795 0.0435795631619226 no 262 0.0350930493770297 377 1043375 YIL048W NEO1
SGTC_2625 euphol 100 µM 1.80967154966205 0.0436693560652155 no 263 0.0351733685020158 320 6708538 A triterpene alcohol.
SGTC_2508 celastrol 40.54 µM 1.80688736700304 0.0439113558755463 no 264 0.0353899213306402 230 122724 Celastrol is a natural product and antioxidant.
SGTC_235 0330-0087 5 mM 1.80027580181057 0.0444903651458979 no 265 0.0359085499206294 314 46494818 YHR062C RPP1
SGTC_2266 7929956 200 µM 1.79751839599954 0.0447336561130302 no 266 0.036126680175141 308 2967153
SGTC_2887 9044784 58.44 µM 1.79749719770668 0.0447355306188011 no 267 0.036128361303113 305 6465546
SGTC_271 rotenone 740 µM 1.7756110321538 0.0467048642173063 no 268 0.0378985251907947 334 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria.
SGTC_825 1988-2224 89.6 µM 1.76949736623428 0.0472672325368147 no 269 0.0384054549576731 322 1180859
SGTC_2720 fluspirilene 36.88 µM 1.76452044420606 0.0477290331751266 no 270 0.0388221982115033 225 3396 An atypical antipsychotic.
SGTC_184 1494-0393 24.714 µM 1.76410277246571 0.047767952025871 no 271 0.0388573388963034 348 3090647
SGTC_164 4100-3994 89.624 µM 1.76317594091826 0.0478544053871857 no 272 0.0389354101160056 371 4615967
SGTC_197 4544-0043 41.561 µM 1.76264158197226 0.0479043064363543 no 273 0.0389804796112804 355 896523
SGTC_3142 9086498 49.47 µM 1.75950252968102 0.0481982881211223 no 274 0.0392460954771878 289 25236367
SGTC_183 3914-0051 30.55 µM 1.75709938806795 0.0484243236461912 no 275 0.03945043501369 296 1596232
SGTC_645 0845-0943 5.41 µM 1.74272213190181 0.0497943857774259 no 276 0.0406910818907846 285 1885106
SGTC_45 0kpi-0036 14.9 µM 1.73993544734991 0.0500634832128084 no 277 0.0409351767661307 280 2795021
SGTC_1999 st074831 12.5 µM 1.73980402408011 0.0500762027350414 no 278 0.0409467178283239 326 17112523
SGTC_1898 st060199 18.6 µM 1.7361065117804 0.0504351157727936 no 279 0.0412725015993287 275 688866
SGTC_655 k060-0012 42 µM 1.73523771965131 0.0505197450540114 no 280 0.0413493539896383 314 5994525
SGTC_1771 st048882 4.1505 µM 1.73448226179198 0.0505934263345227 no 281 0.0414162751973144 303 4580403
SGTC_2516 gossypol 71.55 µM 1.7289425540831 0.051136343326658 no 282 0.0419096884723587 324 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_762 1165-0429 115 µM 1.7248381306224 0.0515415778809276 no 283 0.0422783239516648 314 5967793
SGTC_383 2324-0395 7.37 µM 1.72099095266612 0.0519237288247849 no 284 0.0426262328231591 335 3146421
SGTC_1863 st057641 20.1 µM 1.71935779647096 0.0520866340350855 no 285 0.0427746209741767 341 3921635
SGTC_1023 4482-3888 16 µM 1.71445010683652 0.0525786138272383 no 286 0.0432230464026968 303 3303168
SGTC_1676 st018489 23.4 µM 1.71193082105777 0.0528325926562334 no 287 0.0434547089823216 346 3696235
SGTC_2463 5473429 200 µM 1.71005943513517 0.0530218834520459 no 288 0.0436274414821906 280 5399405
SGTC_911 3456-4043 236 µM 1.70997236136577 0.0530307040463686 no 289 0.0436354920285898 360 914281
SGTC_2007 4011539 71.82 µM 1.70972823973153 0.0530554398326848 no 290 0.0436580690818608 349 45595301
SGTC_1836 st055642 81 µM 1.70738859755629 0.0532929699087906 no 291 0.0438749241517378 347 8571
SGTC_773 4358-1457 44.6 µM 1.7037576157756 0.0536632703385168 no 292 0.0442131896409018 376 1186886
SGTC_1003 4049-0218 100 µM 1.69876286922131 0.0541759789663256 no 293 0.0446819361731664 353 295161
SGTC_49 0717-0965 32.132 µM 1.69488511145031 0.0545766959860119 no 294 0.0450486087133265 337 5889349 YGL099W LSG1
SGTC_1365 1672-3266 55.4 µM 1.69404838453816 0.0546634677607744 no 295 0.0451280446198123 337 6415873
SGTC_1450 4112-4260 37.6 µM 1.69225169397916 0.0548501599972201 no 296 0.0452989969699411 339 1633175
SGTC_562 3772-2733 112 µM 1.68904062001967 0.0551850741808132 no 297 0.0456058229596297 407 2876874 YIL048W NEO1
SGTC_1290 0986-0249 10.2 µM 1.68823784751679 0.0552690550386889 no 298 0.045682790336142 282 53329
SGTC_1070 indatraline 8.81 µM 1.68818548497405 0.0552745363733697 no 299 0.0456878143222027 346 10314472 A monamine transport inhibitor. YGL099W LSG1
SGTC_2544 sphondin 68.51 µM 1.68806651278848 0.0552869920315621 no 300 0.0456992309001491 302 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31
SGTC_2836 9010338 19.48 µM 1.68648333934284 0.0554529516794318 no 301 0.0458513707166078 325 2994051
SGTC_114 0364-0001 490.298 µM 1.68634836847447 0.0554671184743819 no 302 0.0458643599552424 363 4003655
SGTC_345 1362-0200 395 µM 1.68237397220543 0.0558855608504916 no 303 0.0462481726015776 313 1419823
SGTC_2036 5160441 105 µM 1.67104817026426 0.0570916610117102 no 304 0.0473560817846082 425 134534 YIL048W NEO1
SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM 1.67030551367579 0.0571714578867899 no 305 0.0474294664279396 377 23847180
SGTC_2667 digitoxin 100 µM 1.66768687603719 0.0574535256095516 no 306 0.0476889510144557 215 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_852 0418-0143 439 µM 1.66767123729224 0.0574552134265881 no 307 0.0476905040885202 420 5369229
SGTC_2825 7998094 58.44 µM 1.66559278671226 0.0576798782290495 no 308 0.0478972744136211 341 2987815
SGTC_803 4488-1585 147 µM 1.66332011829832 0.0579263265659094 no 309 0.0481241868362203 300 747204
SGTC_415 dibenzyl ketone 100 µM 1.6560661688398 0.0587184853782438 no 310 0.0488542098071708 321 7593
SGTC_2730 imipramine 71.33 µM 1.65566330356704 0.058762727799065 no 311 0.0488950113404697 424 3696 A tricyclic antidepressant.
SGTC_2814 7977482 42.97 µM 1.65393198833596 0.0589531576709018 no 312 0.0490706661407851 440 6456762
SGTC_176 1486-1328 72.834 µM 1.65277843349445 0.0590803073807958 no 313 0.0491879824114923 398 22310231
SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM 1.65088048565968 0.0592899752422408 no 314 0.0493814906211893 395 676296 Flavone; oxidizing agent.
SGTC_302 1094-0063 18.9 µM 1.64701928428129 0.0597183258246572 no 315 0.0497770410656242 283 5440289
SGTC_648 0375-0473 33.3 µM 1.64505918735021 0.0599366992502325 no 316 0.0499788029805256 388 1713139
SGTC_3242 9133940 49.47 µM 1.63675085556773 0.0608692772004596 no 317 0.0508412690511119 322 17248444
SGTC_1694 st024011 44.9 µM 1.63468858874244 0.0611025072140414 no 318 0.0510571729327893 383 2787533
SGTC_1403 3909-7815 62.9 µM 1.63364006681173 0.0612213562937537 no 319 0.0511672248010845 291 6615483
SGTC_1781 st038725 66.3 µM 1.62763011057851 0.0619060681814264 no 320 0.0518016702524763 468 4270275 YIL048W NEO1
SGTC_2322 7413319 38.22 µM 1.62495998460583 0.062212185631511 no 321 0.0520855427246214 545 1840400
SGTC_2407 paclitaxel 400 µM 1.62471953626187 0.0622398097585686 no 322 0.0521111663457821 407 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_2696 st077691 74.316 µM 1.62408752897319 0.0623124641153454 no 323 0.0521785645923641 335 757133
SGTC_3296 9122258 64.045 µM 1.62308821030265 0.0624274788469995 no 324 0.0522852747622826 369 4730474
SGTC_2522 biochanin a 4.94 µM 1.62192721809302 0.0625613088875006 no 325 0.0524094664435574 323 5280373 A possible chelator.
SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM 1.6208868408649 0.0626814252939493 no 326 0.0525209547609158 339 2724278 An inhibitor of dopamine biosynthesis.
SGTC_3328 9140624 29.0385 µM 1.62045452427298 0.0627313910940279 no 327 0.0525673377566252 361 4904392
SGTC_1620 st003704 16.5 µM 1.6203378275927 0.0627448838502817 no 328 0.0525798636463013 325 2834414
SGTC_490 phenamil 164 µM 1.6148734461175 0.0633792250218603 no 329 0.0531690518684716 253 4755 Irreversibly blocks amiloride-sensitive Na+ channels.
SGTC_2390 9097792 176.6 µM 1.60986637182882 0.0639648515421927 no 330 0.0537135158689731 332 4497149
SGTC_2000 st075254 36.4 µM 1.60731976977218 0.0642643115720918 no 331 0.0539921198316589 308 17234175
SGTC_2335 9018011 154.17 µM 1.59967403771244 0.0651699371746257 no 332 0.0548354571379633 412 6458208
SGTC_1354 1498-1681 81 µM 1.59872767303567 0.0652827180173668 no 333 0.0549405629761466 399 5754243
SGTC_2954 9074818 52.69 µM 1.594095844952 0.0658368909217091 no 334 0.0554572847127561 398 16648742
SGTC_2838 9002687 71.43 µM 1.59281449725561 0.0659908392068466 no 335 0.0556009059549406 347 6457060
SGTC_1935 st074532 41.6 µM 1.59046586415252 0.0662737411370399 no 336 0.0558649171126868 456 2829742
SGTC_3287 9117173 37.0625 µM 1.58363890120237 0.0671014094413884 no 337 0.0566379580250325 283 2789709
SGTC_270 tamoxifen 5.46 µM 1.57763983923935 0.0678352851326866 no 338 0.057324187237488 421 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen. YIL048W NEO1
SGTC_3343 9148379 18.9835 µM 1.57708664570429 0.0679032692162656 no 339 0.0573877947764026 368 1955036
SGTC_2893 9048488 25.97 µM 1.57705612143366 0.0679070219925521 no 340 0.0573913061472556 362 6467338
SGTC_1565 sinapyl alcohol 95.1 µM 1.57165502347935 0.068573579537229 no 341 0.0580152891111281 370 5280507 A phenol propionate derived from cinnamic acid.
SGTC_2257 7960413 200 µM 1.57062566526793 0.0687011847998278 no 342 0.0581348124112039 439 2974689 YIL048W NEO1
SGTC_1301 naphtanilide LB 4.81 µM 1.56398587127336 0.0695286969337088 no 343 0.0589104432421414 396 67238 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_866 0495-0101 262 µM 1.56164408758352 0.0698223753692358 no 344 0.0591859286455508 338 635694
SGTC_1076 itraconazole 331 nM 1.55792537992172 0.0702906916131382 no 345 0.0596254690162123 388 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1
SGTC_1370 2001-0092 44.6 µM 1.55698316636098 0.0704097321707601 no 346 0.0597372410709507 466 790957
SGTC_3348 9149464 3.537 µM 1.5552164747252 0.0706333561335301 no 347 0.0599472609671717 378 1951442
SGTC_2167 5876490 200 µM 1.55403438535422 0.0707832869519936 no 348 0.0600881074102159 398 686534
SGTC_250 brefeldin a 552.239 µM 1.55069495869169 0.071208165785578 no 349 0.0604874016138809 306 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.
SGTC_3236 9132701 49.47 µM 1.54474891712266 0.0719695305562709 no 350 0.0612035038313235 374 24282524
SGTC_634 1611-4317 11.2 µM 1.54441378942283 0.0720126272991679 no 351 0.0612440607889611 430 2843522
SGTC_1308 1187-1617 41.4 µM 1.54438900718691 0.0720158150299834 no 352 0.0612470607542863 447 2882570
SGTC_1600 coumarin 106 71.1 µM 1.54210476946723 0.0723101005710624 no 353 0.0615240680748266 415 100336 A hepatotoxic, DNA x-linker.
SGTC_2820 7989630 71.43 µM 1.5395383652496 0.0726418368384347 no 354 0.0618364596200831 321 2984098
SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM 1.53715679288178 0.0729507230275497 no 355 0.062127459065098 673 16725076
SGTC_978 1416-0512 87.4 µM 1.53270783191701 0.0735304381510999 no 356 0.0626739292994309 458 6814003
SGTC_3333 9141820 12.094 µM 1.53170827715902 0.0736611669463302 no 357 0.0627972194715002 368 1939433
SGTC_3077 9117319 49.47 µM 1.52397089856742 0.074679133872314 no 358 0.063757990501123 335 17154678
SGTC_581 0958-0271 211 µM 1.52382078223764 0.0746989895325661 no 359 0.0637767432946098 497 4591145
SGTC_2790 5423970 71.43 µM 1.51876118338223 0.075370573703978 no 360 0.0644113098799466 466 1376240 YKL165C | YIL048W MCD4 | NEO1
SGTC_867 0518-0118 155 µM 1.51633554745253 0.0756941672500486 no 361 0.0647172637299429 410 6848158
SGTC_2944 9067346 25.62 µM 1.51479881332453 0.0758997232463406 no 362 0.0649116805483487 441 6473075
SGTC_1644 st010134 20.9 µM 1.51158693474044 0.0763307215494159 no 363 0.0653194887450742 364 3818134
SGTC_1606 st000094 49.2 µM 1.50855262016164 0.0767396011090107 no 364 0.0657065749541199 425 1242210
SGTC_2545 solidagenone 89.61 µM 1.50092924739453 0.0777742114015847 no 365 0.0666869312377863 227 6708572 An anti ulcer agent
SGTC_1873 rapamycin 2 nM 1.4994592208144 0.0779749289109958 no 366 0.0668772701003314 491 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1
SGTC_843 0310-0051 143 µM 1.49820604909589 0.0781463471865474 no 367 0.0670398622483791 411 2065037
SGTC_2742 clothiapine 36.27 µM 1.49689192448153 0.0783264099413414 no 368 0.0672106909146756 346 16351 An atypical antipsychotic. YIL048W NEO1
SGTC_1219 1469-0211 33.1 µM 1.49466445213395 0.0786323389218904 no 369 0.0675010180306649 389 6822282
SGTC_2711 st079103 59.1 µM 1.48978929025233 0.0793050699310086 no 370 0.0681398239952353 367 54693780
SGTC_206 4546-0025 72.014 µM 1.48878117490096 0.0794447233478662 no 371 0.0682725005363491 498 6620745 YIL048W NEO1
SGTC_1547 harmine 94.2 µM 1.48682874356434 0.0797157212800849 no 372 0.0685300239326468 505 5280953 A monoamine oxidase inhibitor YHR072W ERG7
SGTC_1019 4262-0212 3.4 µM 1.48514301306535 0.0799502631042449 no 373 0.0687529720025531 521 4677213
SGTC_174 3553-0389 74.3 µM 1.48407330840775 0.0800993653981922 no 374 0.0688947367105243 382 738071
SGTC_2793 7325131 81.82 µM 1.47603376003066 0.0812267030178784 no 375 0.0699674147375392 386 4176441
SGTC_1678 st019265 80.2 µM 1.47354317577927 0.0815783601765401 no 376 0.0703023153668845 471 5367020
SGTC_3078 9116413 49.47 µM 1.46644278031936 0.0825871988292003 no 377 0.0712638494263736 402 17177322
SGTC_785 1270-0111 65.3 µM 1.46527023693824 0.0827546957294114 no 378 0.0714236017085561 452 6741994
SGTC_156 3474-0145 5.642 µM 1.4643009122291 0.0828933559037114 no 379 0.0715558740215496 440 2265471
SGTC_1511 0906-3109 28.5 µM 1.46380524502589 0.0829643277200944 no 380 0.0716235844705187 549 2882180
SGTC_2148 5546263 113.568 µM 1.46268347596914 0.0831251163237759 no 381 0.071777004849766 432 792097
SGTC_462 ag-879 158 µM 1.45538315467652 0.084177236170569 no 382 0.0727816086404225 487 6809654 Ag-879 is a 5-Lipoxygenase inhibitor.
SGTC_2338 7999974 200 µM 1.45432186749849 0.0843310170591986 no 383 0.0729285452658091 478 315925
SGTC_1541 2',3',6-trimethoxyflavone 64 µM 1.45378780289431 0.0844084829042797 no 384 0.0730025730556731 463 688801
SGTC_1404 3909-7820 48.3 µM 1.45091337349819 0.084826334918894 no 385 0.0734019917379715 431 23741373
SGTC_1024 4507-0395 26 µM 1.44719281004253 0.085369488813554 no 386 0.0739214648605445 450 4201836
SGTC_2850 9015429 58.44 µM 1.44631531030737 0.0854979712197726 no 387 0.0740443917151004 422 6457570
SGTC_443 clozapine 122 µM 1.44558201042944 0.0856054510931264 no 388 0.0741472376875287 355 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_2737 bleomycin 30.5 nM 1.44116435062985 0.0862550896305819 no 389 0.0747691285756485 516 16211318 Bleomycin acts by induction of DNA strand breaks.
SGTC_2044 5102272 200 µM 1.44030211964349 0.0863823138678846 no 390 0.0748909709959632 399 592666
SGTC_2576 guaiol 23.12 µM 1.43836135356251 0.0866691918217086 no 391 0.0751657760006266 484 227829
SGTC_1755 st041960 45.185 µM 1.4374561582227 0.0868032382093048 no 392 0.0752942108123181 443 2257073
SGTC_362 0310-0100 9.03 µM 1.43730049508166 0.0868263052798 no 393 0.0753163141265186 476 790235
SGTC_1537 2',6'-dihydroxyflavanone 78 µM 1.43659537086829 0.0869308520565805 no 394 0.0754164998586169 507 5106787 A p450 inhibitor.
SGTC_3258 9138477 49.47 µM 1.4347473547258 0.0872052983639624 no 395 0.075679552317072 433 4970355
SGTC_2490 carminic acid 95.39 µM 1.43460953892873 0.0872257910897474 no 396 0.0756991974247553 371 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_1287 0971-0001 34.6 µM 1.4312167017134 0.0877314286256954 no 397 0.0761840591529528 515 4665869
SGTC_19 0279-0214 38.434 µM 1.43112411300522 0.087745257788684 no 398 0.07619732382537 557 3566274 YBR002C RER2
SGTC_1669 st015249 58.4 µM 1.43052368627811 0.0878349777294495 no 399 0.0762833863085375 423 722793
SGTC_1319 1306-0155 43.7 µM 1.42558218590274 0.0885759714956692 no 400 0.076994490679683 519 3122360
SGTC_1072 oxiconazole 14.9 nM 1.42422065938976 0.0887809527011986 no 401 0.0771913031404521 501 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_2429 5902844 64.44 µM 1.42314339140895 0.0889433882269138 no 402 0.0773472959212883 491 1927790 YGL093W | YPR107C SPC105 | YTH1
SGTC_291 SEC14.278 35.5 µM 1.42193139675406 0.0891264028344478 no 403 0.0775230837883208 474 1068044
SGTC_804 1595-0054 20.9 µM 1.41891550150133 0.0895830276324322 no 404 0.0779618261928571 449 761523 Stimulates phospholipase C.
SGTC_376 3970-0862 59.1 µM 1.41627311904452 0.0899845281592176 no 405 0.0783477774872549 488 3135186
SGTC_414 piperonyl butoxide 100 µM 1.41589511690676 0.0900420733813959 no 406 0.0784031074292875 437 5794 A potent inhibitor of cytochrome P450.
SGTC_2065 5221596 34.26 µM 1.41583118753675 0.0900518083829783 no 407 0.0784124679986171 470 788581
SGTC_2770 toltrazuril 17.5 µM 1.41097058201042 0.0907942610207577 no 408 0.0791266442063377 487 68591 Kills coccidiodes.
SGTC_3126 9127922 49.47 µM 1.41009119801172 0.0909290699039617 no 409 0.0792563779810346 495 45595682
SGTC_2417 cerulenin 830 nM 1.40758652270122 0.0913138483979742 no 410 0.0796267702555986 433 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1
SGTC_1576 erythromycin ethylsuccinate 23.2 µM 1.40444981642982 0.0917974229041388 no 411 0.080092472696302 492 3256 An antibiotic and ribosome inhibitor.
SGTC_1381 2324-0066 62.1 µM 1.40313411845682 0.0920008230028909 no 412 0.0802884243912723 490 10885928
SGTC_819 1013-0258 27.7 µM 1.39992420853355 0.092498458433609 no 413 0.0807680079000297 490 5753198
SGTC_46 0329-0187a 2.197 µM 1.39292382071442 0.0935906377380079 no 414 0.0818214141303442 594 46494817
SGTC_1995 st072814 61.1 µM 1.39145405720884 0.0938211504862076 no 415 0.0820438910393853 443 5769371
SGTC_2467 5474540 200 µM 1.38251899077662 0.0952315200171973 no 416 0.0834062017559954 489 5413519
SGTC_2852 9023854 51.95 µM 1.38067963414161 0.0955237838290346 no 417 0.0836887429612862 514 19798528
SGTC_512 prima-1 270 µM 1.37643661397728 0.0962004934961828 no 418 0.084343249443318 515 322968 A re-activator of the apoptotic function of mutant p53.
SGTC_593 1203-0218 61.7 µM 1.37563430038273 0.096328847881811 no 419 0.0844674408835807 503 3666956
SGTC_1454 4239-0054 42.6 µM 1.37560171084431 0.0963340642253483 no 420 0.0844724883698342 553 1340767
SGTC_1558 st069300 45.6 µM 1.37393160390099 0.0966016627091967 no 421 0.0847314585266447 401 24208000
SGTC_1581 himbacine 57.9 µM 1.37372467388843 0.0966348567463316 no 422 0.0847635869217968 525 5281825 An alkaloid muscarinic receptor antagonist.
SGTC_2365 9042475 200 µM 1.37368423440767 0.0966413446989313 no 423 0.0847698667087634 516 6464479
SGTC_225 nsc-122657 1.016 µM 1.37254247659029 0.0968246559354569 no 424 0.0849473125904017 344 275685
SGTC_2989 9073649 71.4286 µM 1.37180596805471 0.0969430390760019 no 425 0.0850619244474724 596 21367202
SGTC_884 0851-0618 334 µM 1.36986577802586 0.0972554052851223 no 426 0.0853644020730079 530 9642473
SGTC_3003 9075612 71.4286 µM 1.36459106467641 0.0981083541327349 no 427 0.0861908073572052 492 6501993
SGTC_1215 3852-0577 11.2 µM 1.36321672951831 0.0983314887004046 no 428 0.0864071081473635 563 2884876
SGTC_205 1486-1330 71.903 µM 1.35403934470759 0.09983104601965 no 429 0.0878619128238595 441 4118834
SGTC_3261 9137475 49.47 µM 1.35252081177851 0.100080771904615 no 430 0.0881043828334913 294 17027690
SGTC_1174 0739-0097 51.1 µM 1.34772863443856 0.100871845759818 no 431 0.088872839378967 531 728447
SGTC_3010 9080089 71.4286 µM 1.34545184435406 0.101249282914283 no 432 0.0892396812471646 501 17027233
SGTC_337 1315-0038 354 µM 1.34101063237578 0.101988488660525 no 433 0.0899585002807169 510 1626437
SGTC_928 2764-0428 58.7 µM 1.340757410559 0.102030753527576 no 434 0.0899996140194002 547 662578
SGTC_1441 4106-0040 13 µM 1.33940694973462 0.102256372120836 no 435 0.0902191140928359 502 2904180
SGTC_845 0330-0138 4.51 µM 1.33826044214941 0.102448201318415 no 436 0.0904057760743573 514 9039800
SGTC_3213 9129884 49.47 µM 1.33569193886069 0.102878902755355 no 437 0.0908249926387794 444 17190742
SGTC_1807 st050092 58.9 µM 1.33147376341106 0.103589082543665 no 438 0.0915165861621898 503 5008496
SGTC_1286 0929-0070 131 µM 1.33075174567937 0.103710998502334 no 439 0.0916353551822031 550 1420408
SGTC_382 3229-0966 23.2 µM 1.32891577030871 0.104021480078096 no 440 0.0919378801521055 552 5722370
SGTC_2382 9035899 200 µM 1.32251355651411 0.10510942971927 no 441 0.092998599079995 547 6462679
SGTC_3326 9140064 16.379 µM 1.32243845202101 0.105122241162578 no 442 0.0930110958531243 496 1868434
SGTC_1848 st056003 16.4 µM 1.32198958101769 0.105198833849988 no 443 0.0930858101951769 557 146492
SGTC_268 camptothecin 39.6153 µM 1.31951777229486 0.105621332155107 no 444 0.0934980362836172 637 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_301 4119-0100 24.5 µM 1.31836228936024 0.10581925541843 no 445 0.0936911991627387 590 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1
SGTC_3199 9111318 49.47 µM 1.31647928222255 0.106142370851029 no 446 0.0940066138155435 514 8548020
SGTC_497 capsazepine 133 µM 1.31486245013274 0.106420380098477 no 447 0.0942780672590803 515 2733484 A calcium channel blocker.
SGTC_2202 7226349 200 µM 1.30844921024156 0.107528295316402 no 448 0.0953604953819405 471 844334
SGTC_781 4335-2806 94.4 µM 1.3078988249735 0.107623762633271 no 449 0.0954538140678954 616 845254
SGTC_115 0527-0192 112.043 µM 1.30426886787536 0.108254928317371 no 450 0.0960709630494042 643 4233931
SGTC_3260 9137109 49.47 µM 1.30372155005986 0.108350324893024 no 451 0.0961642695119992 426 17478346
SGTC_1749 st037932 54.2 µM 1.3035894246757 0.108373363187244 no 452 0.0961868041592847 515 594497
SGTC_3079 9117512 49.47 µM 1.29854464639271 0.109255643800384 no 453 0.0970501224740869 544 7185044
SGTC_759 3486-0358 89.3 µM 1.29647029363476 0.109619920310571 no 454 0.0974067540440948 595 875103
SGTC_1337 1486-1011 40.3 µM 1.29512560894134 0.109856525408797 no 455 0.0976384509757363 540 X1337
SGTC_2488 5268135 45.7 µM 1.29404029674302 0.110047759528823 no 456 0.0978257510402809 649 1270356 YLR208W SEC13
SGTC_2388 9080168 200 µM 1.29278611909 0.110269045397933 no 457 0.0980425212883343 503 15943073
SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM 1.29048923314902 0.110675132699044 no 458 0.0984404238742548 527 5355888
SGTC_75 0159-0059 199.013 µM 1.29045613651175 0.110680991976304 no 459 0.0984461660217915 538 5377270
SGTC_358 0075-0058 9.45 µM 1.28850242416991 0.111027262241871 no 460 0.0987855627699922 651 1069125
SGTC_1885 st057546 99.9 µM 1.28730740497133 0.111239446011506 no 461 0.0989935817865936 580 702008
SGTC_1206 3978-0017 132 µM 1.28692481104494 0.111307439472761 no 462 0.099060248229093 523 3873677
SGTC_1525 8-methoxypsoralen 92.5 µM 1.28499420884719 0.111650994232449 no 463 0.0993971538688748 625 4114 Related to psoralen; DNA damaging agent.
SGTC_1251 0490-5699 265 µM 1.2807095821978 0.11241616113848 no 464 0.100147846407538 627 3883818
SGTC_2363 9053361 176 µM 1.27657326757964 0.113158389033898 no 465 0.100876472324038 584 6469797 YMR079W SEC14
SGTC_1991 st073000 8.92 µM 1.27580918723577 0.113295878750921 no 466 0.101011489554507 625 4301969 YIL048W NEO1
SGTC_1144 3486-0183 12.5 µM 1.27447722010202 0.113535839681946 no 467 0.101247170412823 616 6744069
SGTC_1429 4049-0205 9.46 µM 1.27363891912712 0.113687049728424 no 468 0.101395706315405 600 22774478
SGTC_249 wiskostatin 11.211 µM 1.27249515823624 0.113893589125689 no 469 0.101598621645066 572 2775510 A n-wasp and actin depolymerizer.
SGTC_2153 5569715 200 µM 1.27162512363097 0.114050878209048 no 470 0.101753172928403 541 2054701
SGTC_2252 omeprazole 400 µM 1.27142047084307 0.114087898804257 no 471 0.101789551910084 459 4594 A proton pump inhibitor.
SGTC_1126 isoteolin 1.0172 µM 1.27034071420611 0.11428336272978 no 472 0.101981645694838 562 133323
SGTC_1833 st055984 71 µM 1.2680314279711 0.114702203471296 no 473 0.102393363727208 547 676288
SGTC_3265 9137266 49.47 µM 1.26514178878241 0.115227841178217 no 474 0.102910252537307 494 17224265
SGTC_1430 4049-0248 69.1 µM 1.25900057470274 0.116350635626488 no 475 0.104015062145606 636 22774488
SGTC_1886 st057356 49.9 µM 1.25816042101628 0.116504841941573 no 476 0.10416687277492 545 24207747
SGTC_2645 abamectin 100 µM 1.25642049898665 0.116824657394016 no 477 0.1044817766615 566 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels.
SGTC_2219 9098279 200 µM 1.25414938383425 0.117243047202737 no 478 0.104893856739639 544 902349
SGTC_1341 1486-1360 280 µM 1.25252617816623 0.117542727359764 no 479 0.105189097751814 589 3976547
SGTC_614 0462-0418 107 µM 1.25186004037361 0.11766586813762 no 480 0.105310433833601 516 5188303
SGTC_1750 st081859 2.357 µM 1.2504542423748 0.117926040500758 no 481 0.10556683026539 763 5291695
SGTC_1465 k213-0056 144 µM 1.24665415038324 0.118631363336083 no 482 0.106262168618533 564 24048857 YMR208W ERG12
SGTC_918 glabranin 770.725 nM 1.24563348659819 0.118821312234806 no 483 0.106449491308951 595 124049 Also referred to as licorice root.
SGTC_2340 7987427 183.45 µM 1.24413956864817 0.119099722466287 no 484 0.106724100161036 580 2239331
SGTC_893 0958-0369 48.9 µM 1.24185138507697 0.119527046378744 no 485 0.107145699862615 626 6819948
SGTC_1773 st048542 73.5835 µM 1.23711647445661 0.120414734584369 no 486 0.108021922219498 613 3237138
SGTC_246 cycloheximide 667 µM 1.23676396288245 0.120481007724945 no 487 0.108087362264075 516 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells.
SGTC_1342 1486-1464 234 µM 1.23292609657102 0.121204199598037 no 488 0.108801669025745 628 3253938
SGTC_2974 9094440 9.66 µM 1.23286977793926 0.121214834732742 no 489 0.108812176304404 628 25236134
SGTC_2756 carbadox 75.1 µM 1.22884142673086 0.121977246193973 no 490 0.10956563296572 616 2553 A substituted quinoxaline antibiotic. YLR208W SEC13
SGTC_2233 sulbentine 40.3845 µM 1.22708534176211 0.122310657265385 no 491 0.109895258299152 664 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58
SGTC_2197 6588183 93.1375 µM 1.22651602531827 0.122418885121202 no 492 0.110002274254089 542 884136
SGTC_3134 9127454 49.47 µM 1.22456380646227 0.122790514960562 no 493 0.110369805884218 594 24262820
SGTC_3081 9117243 49.47 µM 1.223970615634 0.122903592993722 no 494 0.110481656312922 575 45595589
SGTC_1009 4106-0057 9.87 µM 1.22191533972565 0.123295948220245 no 495 0.110869821958683 615 2928005
SGTC_947 3447-0010 211 µM 1.22141513643882 0.123391570414749 no 496 0.110964439518863 591 748350
SGTC_2286 7945697 125 µM 1.2161161464915 0.12440775175595 no 497 0.111970340276848 607 1245733
SGTC_277 nystatin 15.5 µM 1.21516071685107 0.124591594337684 no 498 0.112152399896013 628 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_2046 4110841 106 µM 1.21470465335548 0.124679416436214 no 499 0.112239378555976 606 44119630 YMR134W ERG29
SGTC_3332 9141069 11.198 µM 1.21127210115432 0.125341795965347 no 500 0.11289556872711 543 17332883
SGTC_2313 7726885 200 µM 1.21122971610331 0.125349990332888 no 501 0.112903688423919 604 726423
SGTC_851 0394-0702 453 µM 1.21109509953096 0.125376018443288 no 502 0.112929479661631 670 762646
SGTC_2174 5790901 200 µM 1.2104353995892 0.125503625952732 no 503 0.113055932614944 602 786020
SGTC_786 4544-0069 423 µM 1.21027881545889 0.125533927742037 no 504 0.113085961890052 649 748821 YLR208W SEC13
SGTC_1045 1348-1485 165 µM 1.20772389575205 0.126029071116312 no 505 0.113576741677778 665 6810614
SGTC_796 1234-0020 70.7 µM 1.20464144698724 0.126628259952686 no 506 0.114170874524546 610 46495034
SGTC_533 1222-0222 6.71 µM 1.20326028120077 0.126897383671658 no 507 0.114437807034645 660 3982874
SGTC_3270 9137563 49.47 µM 1.20208914156585 0.12712589499209 no 508 0.114664496449079 554 17015724
SGTC_2051 5263410 176 µM 1.20141353654768 0.127257848366002 no 509 0.114795413895871 641 227584
SGTC_1135 dihydrocapsaicin 536.708 nM 1.20033255457297 0.127469174621682 no 510 0.11500510564591 604 107982 A Capsaicinoid.
SGTC_298 1391-0729 10 µM 1.19851057872632 0.127825913310135 no 511 0.115359153576608 589 3237558
SGTC_159 3970-0959 50 µM 1.19808277359698 0.12790977705712 no 512 0.115442397222031 841 6615653
SGTC_1170 0310-0127 64.8 µM 1.19781133269466 0.127963008140045 no 513 0.115495237161902 641 774975
SGTC_2058 5236698 133 µM 1.19722773475396 0.128077507081444 no 514 0.115608901220579 602 766665
SGTC_1952 st077036 64.1 µM 1.19665368916034 0.128190201310221 no 515 0.115720782327637 626 2937007
SGTC_1258 0671-0043 57.1 µM 1.19632254727078 0.128255241011482 no 516 0.115785356628561 628 4298767
SGTC_541 4513-1321 94 µM 1.18974998238136 0.129550903547215 no 517 0.117072336919598 614 747515
SGTC_338 4055-0136 114 µM 1.18874002670534 0.129750798989612 no 518 0.117270992260467 629 2900563
SGTC_604 1000-0114 314 µM 1.18775667574106 0.129945633827642 no 519 0.117464643828192 675 1572745
SGTC_3141 9094609 49.47 µM 1.1877391641151 0.129949105303126 no 520 0.117468094448129 596 25236309 YDL196W YDL196W
SGTC_53 0973-0023 39.979 µM 1.18684743395382 0.130125965278276 no 521 0.117643902426675 607 674768
SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM 1.18564146793476 0.130365413619668 no 522 0.117881959332 612 6710655
SGTC_2022 5136654 200 µM 1.17380750123218 0.132731257890715 no 523 0.120236069371371 629 1713771
SGTC_672 1441-0018 53.7 µM 1.1734011484114 0.132813017652935 no 524 0.120317488457 606 251141
SGTC_1624 st003710 6.25 µM 1.17298263885218 0.1328972596442 no 525 0.120401383924652 695 24207033
SGTC_1569 carminic acid 40.6 µM 1.17256007449285 0.13298235514787 no 526 0.120486134023029 668 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_2595 hexamethylquercetagetin 100 µM 1.17236685128571 0.133021278700355 no 527 0.120524901133381 618 386331
SGTC_1950 st077106 7.18 µM 1.17049376434694 0.133399006330538 no 528 0.120901161044063 656 13831864
SGTC_2292 7671323 168.05 µM 1.16938780250582 0.133622381253759 no 529 0.121123710966517 634 937504
SGTC_2354 9060492 162 µM 1.16879828449589 0.13374155326284 no 530 0.121242455863668 712 6471895
SGTC_847 0342-0274 5.54 µM 1.16852109688076 0.133797612429633 no 531 0.121298317246721 663 18097
SGTC_62 0180-0423 3.232 µM 1.16753770824935 0.13399662587316 no 532 0.121496644712725 625 30102 YGL099W LSG1
SGTC_1289 0976-0073 69.1 µM 1.16656789429764 0.134193091256828 no 533 0.121692457612678 687 3391136
SGTC_577 r071-0003 38.6 µM 1.16597093630506 0.134314121630495 no 534 0.121813098232778 794 4568517 YMR134W ERG29
SGTC_2689 tacrolimus 100 µM 1.16572171327746 0.134364672579786 no 535 0.121863489144203 618 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12).
SGTC_2605 digitonin 300 nM 1.16374429901707 0.134766222828654 no 536 0.122263825618085 743 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_1892 st058411 7.36 µM 1.1630566916765 0.134906046865636 no 537 0.122403250930995 718 3934738
SGTC_1544 7-methoxy-4-methylcoumarin 105 µM 1.16164760271373 0.135192894068924 no 538 0.122689318743004 646 390807
SGTC_2111 5486399 200 µM 1.15761922548675 0.136015253278747 no 539 0.123509730020952 719 689674
SGTC_692 k241-0027 77.8 µM 1.15743456682395 0.136053031695806 no 540 0.123547429122575 642 3600480
SGTC_88 0180-0332 8.668 µM 1.15676721260927 0.13618962232871 no 541 0.123683740417043 655 3101745
SGTC_390 dec-rvkr-cmk 16.7 µM 1.15408618556284 0.136739306802917 no 542 0.12423241820664 686 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1
SGTC_1270 0831-1170 17.3 µM 1.15328378530297 0.136904115483117 no 543 0.124396961631023 717 6764716
SGTC_1921 5740136 50 µM 1.15111220739473 0.137350826534994 no 544 0.124843038258928 717 1774243
SGTC_2183 6420625 130.508 µM 1.15089664763074 0.13739522315702 no 545 0.124887378563338 723 2897619
SGTC_2482 5981709 142.65 µM 1.14689515615029 0.138221148559489 no 546 0.125712477435574 690 877755
SGTC_3116 9124943 49.47 µM 1.14681870278562 0.13823696175436 no 547 0.12572827889021 600 41905195 YPL160W CDC60
SGTC_1672 st016598 6.51 µM 1.14476445001782 0.138662313961563 no 548 0.126153372667779 653 4665860 YNL267W PIK1
SGTC_1866 st057638 64 µM 1.14394614892488 0.13883199889495 no 549 0.126322985316936 667 688802
SGTC_442 cape 100 µM 1.1436630967611 0.138890726192592 no 550 0.126381691682612 624 5281787
SGTC_335 4077-0256 27.6 µM 1.14363959789621 0.138895602467102 no 551 0.12638656631348 751 3121989
SGTC_3202 9113761 49.47 µM 1.14237335730393 0.139158533794193 no 552 0.12664943042418 725 4798415
SGTC_1357 1503-1303 39.5 µM 1.14055884336353 0.139535902731618 no 553 0.12702677621672 709 292895
SGTC_1474 0330-0125 5.35 µM 1.13724300816103 0.140227301723835 no 554 0.127718356165509 681 X1474
SGTC_505 gw-5074 63.9 µM 1.13598483682407 0.140490256376827 no 555 0.127981455197168 680 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases.
SGTC_1634 st006576 41 µM 1.13535845656861 0.140621293015292 no 556 0.128112579277169 670 3915356
SGTC_522 1273-0010 11.6 µM 1.13301158310855 0.141112988521951 no 557 0.128604694549148 651 5705015
SGTC_421 streptovitacin 30 mM 1.13019356817586 0.141704931985228 no 558 0.129197334682184 711 91467 include heat shock
SGTC_3339 9145883 14.936 µM 1.12938996152699 0.141874042861099 no 559 0.129366682833869 645 2030670
SGTC_543 3844-1095 191 µM 1.1291667400994 0.141921041790703 no 560 0.129413750717781 725 4230703
SGTC_253 dyclonine 31.25 µM 1.12899436982954 0.141957341299195 no 561 0.129450104378706 736 3180 An oral anasthetic.
SGTC_2069 5228469 200 µM 1.12863113914995 0.142033854738262 no 562 0.129526734518125 643 2835210
SGTC_1736 st036774 51 µM 1.12862991097314 0.142034113497322 no 563 0.129526993677731 710 1272247
SGTC_2485 5633444 17.78 µM 1.1285571199958 0.142049450071616 no 564 0.129542354063079 658 5724239
SGTC_889 0919-1524 82.7 µM 1.12828253416296 0.142107313568153 no 565 0.129600308649702 649 3905452
SGTC_1119 parthenolide 318.541 nM 1.12820400899115 0.142123864117575 no 566 0.129616885617673 748 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs.
SGTC_2744 captopril 92.04 µM 1.12802334956349 0.142161946195838 no 567 0.129655029099022 610 44093 angiotensin-converting enzyme (ACE) inhibitor
SGTC_134 0269-0018 6.916 µM 1.12784320042964 0.142199927582774 no 568 0.129693072580689 691 4378915
SGTC_2932 9016711 44.54 µM 1.12265054538166 0.143297662765673 no 569 0.130792969691345 732 7117328
SGTC_188 3229-0966 278.469 µM 1.12231232374829 0.143369361315378 no 570 0.130864834060672 796 5722370
SGTC_2353 9059630 146.67 µM 1.12144635683843 0.14355304533288 no 571 0.131048956606397 657 4779114
SGTC_1940 st075990 51.1 µM 1.12109696706141 0.143627200877438 no 572 0.131123294775565 750 1084979
SGTC_1874 staurosporine 7.6 µM 1.12034834775508 0.143786177136298 no 573 0.131282673362262 714 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1
SGTC_1664 st014217 9.02 µM 1.10878818490265 0.146256157481106 no 574 0.133760784312496 755 3982782
SGTC_1405 3909-7894 12 µM 1.10569054633083 0.146922820712592 no 575 0.13443024162305 697 7104060
SGTC_3175 9106517 49.47 µM 1.1050957040025 0.147051073557436 no 576 0.134559060951178 684 41468073
SGTC_2330 7979373 200 µM 1.10392673377638 0.147303331710586 no 577 0.134812460491693 694 1863007
SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM 1.10157289491668 0.147812158321705 no 578 0.135323698766028 719 442882
SGTC_2643 anethole 100 µM 1.10075438786932 0.147989369480657 no 579 0.135501784092391 747 637563 An anti-fungal, anti-helmenthic and channel blocker.
SGTC_1229 0139-0193 12.2 µM 1.10070723938735 0.1479995817094 no 580 0.135512047235285 749 3090752
SGTC_2601 securinine 100 µM 1.09933141367855 0.148297789400805 no 581 0.135811767494197 680 442872 A GABA receptor antagonist.
SGTC_2512 diallyl trisulfide 49.23 µM 1.09873807499555 0.148426518434401 no 582 0.135941164876981 661 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent
SGTC_2401 5128683 200 µM 1.09857996723469 0.148460833640421 no 583 0.135975659811095 642 708373
SGTC_1154 4088-0362 150 µM 1.09684993950199 0.148836659983888 no 584 0.136353497666924 770 6618304
SGTC_495 decylubiquinone 155 µM 1.09491387626593 0.149257998141189 no 585 0.136777184614239 676 2971 A Co-enzyme Q analog. A free radical scavenger.
SGTC_2588 indole-3-carbinol 100 µM 1.09421094366405 0.149411171603041 no 586 0.136931236436081 753 3712 Induces cell cycle arrest.
SGTC_333 3486-0131 40.1 µM 1.09284501299548 0.149709116497816 no 587 0.137230927167035 746 6744690
SGTC_470 aa-861 153 µM 1.09268321182947 0.149744435766663 no 588 0.137266456654176 737 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor.
SGTC_1720 st037298 9.481 µM 1.09238459469243 0.149809634928856 no 589 0.137332045692113 684 597396
SGTC_2602 kawain 100 µM 1.09227704978864 0.149833120594763 no 590 0.137355672373114 777 5369129
SGTC_2453 5731132 22.18 µM 1.08394620293776 0.1516598758256 no 591 0.139194326142766 765 1362040
SGTC_1733 st037357 54.9 µM 1.08306509252628 0.151853944216532 no 592 0.139389765897372 713 1272339 YGL099W LSG1
SGTC_1814 st052110 31.539 µM 1.08278209659928 0.15191631028888 no 593 0.139452577022961 690 674163
SGTC_2837 9008476 45.46 µM 1.08211273111709 0.152063891418243 no 594 0.139601219730494 719 2992805
SGTC_1718 roemerine 11.9335 µM 1.08201661846233 0.152085090069162 no 595 0.139622571838644 744 235224 An aporphine alkaloid with mutagenic activity.
SGTC_2348 9022543 33.42 µM 1.07854910506177 0.152851199069018 no 596 0.140394390043655 739 3162678 YDL140C RPO21
SGTC_2988 9073640 71.4286 µM 1.06979806496716 0.154796005873754 no 597 0.142355106751337 685 9102229
SGTC_16 erodoxin 22.806 µM 1.05848712336381 0.157333834384027 no 598 0.14491670910713 794 3967339 Erodoxin inhibits Ero1. YML130C ERO1
SGTC_1739 st037196 92.5 µM 1.05771063433011 0.157509052367787 no 599 0.14509369275986 797 612214
SGTC_2775 cyproheptadine 69.59 µM 1.05737568799116 0.157584673976498 no 600 0.145170081326621 758 2913 A selective serotonin reuptake inhibitor.
SGTC_2802 7925815 54.55 µM 1.05621925444833 0.157845947984612 no 601 0.145434027987784 741 1262923
SGTC_2032 5185112 25.99 µM 1.05439650914114 0.158258339622736 no 602 0.145850709918198 700 5718189
SGTC_2499 avocadenofuran 51.48 µM 1.05365171225175 0.158427051367395 no 603 0.146021202128093 700 6857792 A insecticide and lysyl oxidase inhibitor.
SGTC_2773 thioridazine 9.09 µM 1.0530480904288 0.158563870592691 no 604 0.146159476006154 769 5452 An antipsychotic.
SGTC_1445 4239-0156 97.7 µM 1.05258482682136 0.158668928229541 no 605 0.146265657141377 834 4008346
SGTC_2220 6782180 200 µM 1.05135815214375 0.158947330479492 no 606 0.14654706406238 643 833803
SGTC_2917 7979103 53.79 µM 1.04629500543661 0.160099831758886 no 607 0.147712425337514 808 2980565
SGTC_3039 9090270 49.47 µM 1.04496582566809 0.160403290149427 no 608 0.148019382225055 709 17173750
SGTC_1960 st011366 51.8 µM 1.0432214085076 0.160802119240947 no 609 0.148422880216958 750 3972846
SGTC_2651 TUB2.036 5 µM 1.04311289166546 0.16082695100629 no 610 0.148448005333462 924 15992207 YFL037W TUB2
SGTC_475 α-linolenic acid 10 µM 1.04160652717587 0.161171908968363 no 611 0.148797070628709 805 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_500 h-89 112 µM 1.03806927588756 0.161983836944679 no 612 0.149618902066667 819 449241 Protein kinase A inhibitor; also known to inhibit several other kinases.
SGTC_297 0986-0032 24 µM 1.03682658115375 0.162269711972156 no 613 0.149908342593729 724 2847425
SGTC_557 1315-0110 16.2 µM 1.03467727737073 0.162764922197454 no 614 0.150409825588526 775 6833801
SGTC_2501 sodium tetradecyl sulfate 13.37 µM 1.03407894220733 0.162902956295413 no 615 0.150549629876522 790 23665772 A membrane-active detergent.
SGTC_214 4373-3496 70 µM 1.03323282756892 0.163098282243243 no 616 0.15074747689171 940 3779166
SGTC_1710 st031758 61.5 µM 1.0328574109245 0.163184996078583 no 617 0.150835315999367 756 5394341
SGTC_2772 vinpocetine 57.06 µM 1.03186080763655 0.163415337071407 no 618 0.151068664159846 751 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor.
SGTC_400 oxethazaine 37.5 µM 1.03007095351811 0.16382954896717 no 619 0.151488349629593 739 4621 A local anesthetic.
SGTC_948 3448-0295 75.3 µM 1.02918648364223 0.164034486225533 no 620 0.151696026273801 809 678569
SGTC_2243 6634756 200 µM 1.02869066337626 0.164149443629945 no 621 0.151812529348792 733 885676
SGTC_810 3825-7150 143 µM 1.02743740459841 0.164440248308244 no 622 0.152107273030099 837 22330411 YGL099W LSG1
SGTC_2865 9030313 51.95 µM 1.01863801176602 0.166491445793895 no 623 0.15418742564538 728 42562754
SGTC_2435 5706476 10.6 µM 1.01828517413779 0.166574037592986 no 624 0.15427122601626 821 5725375
SGTC_3237 9133362 49.47 µM 1.01770099479654 0.166710839703914 no 625 0.154410037188179 789 43845137
SGTC_1775 st081588 35.1725 µM 1.0171681292003 0.166835688457218 no 626 0.154536727314026 816 1426443 YGL099W LSG1
SGTC_1281 0884-0031 11.8 µM 1.01588979517484 0.167135443993171 no 627 0.154840934459864 807 1548255
SGTC_1677 st019204 53.9 µM 1.0146726537099 0.167421173025864 no 628 0.155130946898318 743 3945625
SGTC_2726 cimetidine 79.27 µM 1.01396120575591 0.167588334070948 no 629 0.155300631989699 720 2756 A P450 inhibitor, histamine H2-receptor antagonist.
SGTC_1560 lithocholic acid 53.1 µM 1.01291257515553 0.167834915125474 no 630 0.155550960652187 717 9903 A bile acid which acts as a detergent.
SGTC_346 4513-0042 7.16 µM 1.0090373601261 0.168748180940945 no 631 0.156478358563462 813 2827372
SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM 1.00892549433257 0.168774591513446 no 632 0.156505183705605 778 7104
SGTC_2972 9093619 59.92 µM 1.00797050696349 0.169000164113181 no 633 0.156734310582276 769 25236256
SGTC_449 xestospongin c 11.1929 µM 1.00407298742428 0.169922783679645 no 634 0.157671717261487 814 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1
SGTC_2154 5570129 200 µM 1.00360833808682 0.170032990351937 no 635 0.157783716988833 834 673366
SGTC_2456 5770359 74.46 µM 1.00247758467259 0.170301376583362 no 636 0.158056493632084 826 3118787
SGTC_2308 7584454 197.62 µM 1.00196519404281 0.170423082664797 no 637 0.158180201748768 837 893577
SGTC_2684 capsaicin 100 µM 0.999208397397758 0.171078849255406 no 638 0.158846874400269 771 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_2600 tangeritin 87.95 µM 0.999203074512065 0.171080116983528 no 639 0.158848163405774 733 68077 A bioactive flavone.
SGTC_3086 9117350 49.47 µM 0.998102193774394 0.171342437996229 no 640 0.159114903227767 762 2679265
SGTC_736 0958-0254 92.6 µM 0.993745392304877 0.172383109805361 no 641 0.160173418817709 838 6812352
SGTC_3122 9126309 49.47 µM 0.993361984839646 0.172474883684835 no 642 0.160266790237666 831 17591206
SGTC_1839 st053978 48 µM 0.991470650674713 0.172928056560072 no 643 0.160727908321369 810 3788398
SGTC_2122 5258151 111.688 µM 0.991282125303308 0.172973269702143 no 644 0.160773919320966 800 2173356
SGTC_3105 9121040 49.47 µM 0.988780673107249 0.173573893895937 no 645 0.161385231094423 602 41448907
SGTC_2687 chenodiol 100 µM 0.98745286853203 0.173893251869952 no 646 0.161710338709445 759 5702181 A cholesterol synthesis inhibitor.
SGTC_3210 9128157 49.47 µM 0.983786437103267 0.174777025467882 no 647 0.162610264680947 722 17590849
SGTC_2179 6298986 200 µM 0.983397144646378 0.174871029470017 no 648 0.162706007529773 798 738374
SGTC_1795 st049545 62.3 µM 0.982371876467838 0.175118758570693 no 649 0.162958338091226 819 5291882
SGTC_2481 5478948 45.16 µM 0.982293435289698 0.175137720982064 no 650 0.162977653859363 786 77792
SGTC_821 1114-0266 29.2 µM 0.982291362043667 0.175138222187308 no 651 0.162978164406555 793 3123235
SGTC_226 1,3-diallylurea 8.28947 mM 0.982093500195337 0.175186059286426 no 652 0.163026893659797 782 74537 YKL182W FAS1
SGTC_2811 7967822 32.47 µM 0.981705404880737 0.175279913235128 no 653 0.163122500958629 807 2232244
SGTC_1513 0337-0559 19 µM 0.981190676236069 0.175404440378964 no 654 0.163249360588233 746 775073
SGTC_125 0133-0007 11.75 µM 0.980140923103848 0.175658578573975 no 655 0.163508280569947 931 26541
SGTC_2450 5739737 12.93 µM 0.977608710821186 0.176272569777271 no 656 0.164133943716454 762 2262825
SGTC_507 nimesulide 162 µM 0.97647470339702 0.176547974855848 no 657 0.16441463887819 834 4495 A COX2 inhibitor.
SGTC_836 0330-0104 1.35 µM 0.976267734836847 0.176598268597655 no 658 0.164465902326337 825 46494820
SGTC_1830 st055982 50.3 µM 0.976191397910626 0.176616820898451 no 659 0.164484812615344 833 455313 An antimicrobial agent.
SGTC_1190 1486-1332 13 µM 0.976060470096747 0.176648643390644 no 660 0.164517249515857 827 4150046
SGTC_933 2914-0560 114 µM 0.975893295423077 0.176689281086647 no 661 0.164558672472889 886 463887
SGTC_77 0828-0286 12.516 µM 0.97516394806817 0.176866643804152 no 662 0.164739471039462 819 745345
SGTC_2468 5987765 72.9 µM 0.972142791103198 0.177602526745098 no 663 0.165489758296778 869 26772094
SGTC_360 0957-0399 1.01 µM 0.970017949120943 0.178121244027075 no 664 0.166018772685195 853 6752301 YPR165W RHO1
SGTC_3052 9092717 49.47 µM 0.96765631739893 0.178698885904029 no 665 0.166608020494409 797 25237534
SGTC_1832 st054113 55 µM 0.963574558366711 0.179700038645138 no 666 0.167629633609848 812 1251267
SGTC_1169 aniline yellow 25.8 µM 0.963370933177158 0.179750074895429 no 667 0.167680703883477 814 6051 A DNA damaging agent.
SGTC_3238 9133470 49.47 µM 0.963002201727591 0.17984070452023 no 668 0.167773209178341 839 3534688
SGTC_3064 1327-0027 10 µM 0.960817108143268 0.18037836231872 no 669 0.168322067475168 695 16000455 YPR107C YTH1
SGTC_2792 7535235 81.82 µM 0.960606178633026 0.18043031634496 no 670 0.1683751104292 758 1281891
SGTC_1038 k292-0204 154 µM 0.95918236975886 0.180781260082343 no 671 0.168733440238281 778 4454212
SGTC_2311 7694451 200 µM 0.950987687934935 0.182809413891457 no 672 0.170805312972357 836 2163142
SGTC_1958 st076513 41.9 µM 0.949823756996713 0.183098630152717 no 673 0.171100906188036 845 732122 YGL099W LSG1
SGTC_2951 9072950 58.06 µM 0.949304281206009 0.183227802778406 no 674 0.171232938378607 949 16488155
SGTC_1933 st074711 15.9 µM 0.947666306075035 0.18363547296911 no 675 0.171649679560086 892 17250958
SGTC_2301 7769476 200 µM 0.946068550732739 0.184033677085291 no 676 0.172056811579337 817 977820
SGTC_1247 0448-0043 5.84 µM 0.94164576960482 0.185138755454518 no 677 0.173187014193391 876 3089013 YGL099W LSG1
SGTC_231 b-estradiol 524 µM 0.941489622268852 0.185177845686421 no 678 0.173227002482002 793 450 A steroid.
SGTC_2567 aureobasidin a 60 nM 0.940277036857703 0.185481581151182 no 679 0.173537737588722 824 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1
SGTC_584 0986-0246 15.4 µM 0.939175879239487 0.185757673271531 no 680 0.173820225522824 946 53315 YDR232W HEM1
SGTC_1198 1612-1005 86.7 µM 0.935783385469739 0.186609871122244 no 681 0.174692363754053 895 6998509
SGTC_582 0987-0078 156 µM 0.932762263789103 0.187370814202323 no 682 0.175471364514353 989 1625765
SGTC_334 1502-1024 68.5 µM 0.932111004027152 0.187535100802198 no 683 0.175639580874505 899 3296216
SGTC_131 0141-0277 33.849 µM 0.930302405265013 0.187991804051066 no 684 0.176107266413652 870 1547771
SGTC_1369 1866-0067 208 µM 0.926346885946164 0.188993033138028 no 685 0.177132868613773 934 3531355
SGTC_710 3448-4187 58 µM 0.924036339462294 0.189579400270023 no 686 0.177733698007335 950 3946412
SGTC_1388 3346-4487 254 µM 0.92319424563912 0.189793383615358 no 687 0.177952993542366 932 3345614
SGTC_3136 9095672 49.47 µM 0.922676224225536 0.189925091106846 no 688 0.178087979846383 781 17217380
SGTC_1236 0330-0013 258 µM 0.922400331561579 0.189995260034316 no 689 0.178159898446146 866 4617066
SGTC_1145 3546-0597 10.2 µM 0.921497681878599 0.190224946011532 no 690 0.178395325474337 901 875334
SGTC_1777 st045864 34.765 µM 0.920065549138889 0.190589712782866 no 691 0.178769253038749 893 4691462
SGTC_624 k048-0052 28 µM 0.918868280141845 0.190894988636372 no 692 0.179082236440735 845 6835531
SGTC_2969 9091408 28.7 µM 0.918583569840205 0.190967627291046 no 693 0.179156714530236 833 4286311
SGTC_823 0417-1665 178 µM 0.918053407222943 0.191102933810388 no 694 0.179295453024682 899 3429856
SGTC_1092 toremifene 6.32 µM 0.917860674643029 0.191152137010136 no 695 0.179345906041028 976 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_1463 k081-0032 34.1 µM 0.917208799928449 0.191318613351467 no 696 0.179516618199575 765 977755
SGTC_2087 5276107 200 µM 0.916934413182257 0.191388713047644 no 697 0.17958850480078 872 144405
SGTC_1762 st045503 25.4615 µM 0.916370851852423 0.191532739758273 no 698 0.179736208997835 901 4645554
SGTC_1097 itavastatin 7.23 µM 0.915543747695061 0.191744239064435 no 699 0.179953123485067 915 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49
SGTC_2926 9010726 65.15 µM 0.914504967420835 0.192010068702686 no 700 0.180225784457065 872 2994293
SGTC_2471 5466956 24.79 µM 0.914205412711412 0.192086768293441 no 701 0.180304460274227 873 724419
SGTC_791 1348-1292 225 µM 0.913915678041838 0.19216097134109 no 702 0.180380577431591 953 5437054
SGTC_789 1309-1135 70.6 µM 0.910835464425895 0.192950919089886 no 703 0.181191036662254 891 3092424
SGTC_369 0957-0393 4.5 µM 0.910681025276081 0.192990578504461 no 704 0.181231732317774 842 6997992
SGTC_459 nigericin 15.3 µM 0.910213885235617 0.193110568673254 no 705 0.181354861401478 954 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification.
SGTC_3091 9116372 49.47 µM 0.909609698244966 0.193265828423195 no 706 0.181514191073879 854 17169793
SGTC_2859 9028643 45.46 µM 0.908258884450601 0.193613226573747 no 707 0.181870729913527 879 17151580
SGTC_1013 4112-3890 241 µM 0.907238236259593 0.193875966150379 no 708 0.182140413918209 869 705171
SGTC_341 1486-1430 230 µM 0.907031751454763 0.193929146759519 no 709 0.182195003406565 879 2054753 YPL210C SRP72
SGTC_675 1309-0189 238 µM 0.905988318210307 0.194198021196785 no 710 0.182471017792918 858 4246530
SGTC_2416 tofa 880 nM 0.903272601942918 0.194898877338195 no 711 0.183190616922479 812 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_1148 3909-7663 27.7 µM 0.903195368805601 0.194918831681583 no 712 0.183211107686629 942 4084526
SGTC_2791 5663188 71.43 µM 0.90133410609383 0.195400092559332 no 713 0.183705352528345 880 54690634
SGTC_1700 st030840 7.9285 µM 0.900286619861893 0.195671254926106 no 714 0.183983869866 938 5499307
SGTC_1621 st003705 32.4 µM 0.89993766156023 0.195761640334285 no 715 0.184076713151395 966 24207032
SGTC_3235 9132602 49.47 µM 0.899925690281513 0.195764741523658 no 716 0.184079898727957 923 4912240
SGTC_968 1309-0633 340 µM 0.898258855542747 0.196196830253865 no 717 0.184523781157007 915 3761976
SGTC_199 4063-0024 41.6 µM 0.898076465315765 0.196244145819056 no 718 0.184572392523862 934 306215
SGTC_381 3461-2219 42.7 µM 0.896628563811096 0.196620004979747 no 719 0.18495857547779 935 2883159
SGTC_2432 5630864 12.22 µM 0.892068352710705 0.197806631830482 no 720 0.18617814827034 874 5714970
SGTC_336 4111-0029 111 µM 0.890481938803833 0.198220449931601 no 721 0.186603581109603 861 3131175
SGTC_3334 9142812 21.919 µM 0.88872099105319 0.19868040688293 no 722 0.187076523457221 880 45283678
SGTC_2664 lyso-paf C-16 73.48 µM 0.886977014609313 0.199136564703135 no 723 0.187545637833546 973 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_2700 st077718 96.8 µM 0.886455060338973 0.199273210634762 no 724 0.18768618017108 862 904970
SGTC_256 clotrimazole 625 nM 0.886043615940092 0.199380965230785 no 725 0.187797012267744 909 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C
SGTC_1426 4048-4480 71.7 µM 0.885072238622865 0.199635501736175 no 726 0.18805883561155 944 14224343
SGTC_2721 ifenprodil 61.44 µM 0.884512274081708 0.199782321802552 no 727 0.188209869805001 908 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor.
SGTC_997 3996-0078 137 µM 0.884051434153879 0.199903200571354 no 728 0.188334224138726 951 735687
SGTC_3153 9100258 49.47 µM 0.882564818817546 0.200293440931443 no 729 0.188735721937963 866 25236848
SGTC_2565 isoliquiritigenin 100 µM 0.878131501835456 0.201459912918138 no 730 0.189936179636059 761 638278 Binds to benzodiazepine receptor 65X better than valium.
SGTC_3034 9090421 49.47 µM 0.877327966454445 0.201671770054367 no 731 0.190154263118256 892 17173761
SGTC_2050 5263056 171 µM 0.87682142016108 0.201805392708652 no 732 0.190291821328338 981 763468 YGL055W OLE1
SGTC_1988 st071872 53.4 µM 0.87666358108773 0.201847040160241 no 733 0.190334696750476 965 16414116
SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM 0.876604593394888 0.201862605986351 no 734 0.190350721696452 932 364106
SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM 0.87529169046673 0.202209244212791 no 735 0.190707607130284 939 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_1709 st033179 39.1045 µM 0.875067511879017 0.202268468372462 no 736 0.190768586450872 950 573381
SGTC_1811 st050069 61.5 µM 0.875016982768782 0.202281818734397 no 737 0.190782332639705 945 3877702
SGTC_1021 4476-0760 85.3 µM 0.874569442714103 0.202400086880427 no 738 0.190904110178008 904 746768
SGTC_2941 9056145 11.23 µM 0.874015922999716 0.202546418680514 no 739 0.191054791172878 860 2119517
SGTC_135 0933-0004 26.348 µM 0.872994774437683 0.202816541554539 no 740 0.19133296299094 882 21230617 YGL099W LSG1
SGTC_1091 telmisartan 47.6 µM 0.872435706016625 0.202964522198634 no 741 0.191485364322902 958 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension.
SGTC_1759 st043059 70 µM 0.870201210542891 0.203556617683518 no 742 0.192095227255691 943 669426
SGTC_3345 9148410 3.559 µM 0.866965540493355 0.204415827484438 no 743 0.192980445421881 941 4903596
SGTC_1181 1222-0449 220 µM 0.866620601007892 0.204507550941817 no 744 0.193074961064296 952 658318
SGTC_3197 9113331 49.47 µM 0.863787236001221 0.205261902402769 no 745 0.193852390440116 943 16610459 YLR208W | YDL195W SEC13 | SEC31
SGTC_329 k048-0121 21.3 µM 0.86368655715504 0.20528873738737 no 746 0.193880050139651 930 6832902
SGTC_22 0964-0034 14.468 µM 0.862644769179253 0.205566538358329 no 747 0.194166403821812 993 138402
SGTC_982 1491-0518 27.5 µM 0.860354771800889 0.206177968116091 no 748 0.194796754587205 893 3091256
SGTC_1493 4348-0038 111 µM 0.85940080066827 0.206432996387841 no 749 0.195059714070649 1026 800424
SGTC_2285 7945142 200 µM 0.857605728900202 0.206913385312051 no 750 0.195555105286762 912 2970608
SGTC_1856 st057054 55.7 µM 0.856223139044276 0.207283838343748 no 751 0.195937182989636 991 1266018
SGTC_731 3966-0296 387 µM 0.855847051940902 0.207384675452139 no 752 0.196041192693101 960 660956
SGTC_175 3793-3120 23.7 µM 0.855525992781533 0.207470781316914 no 753 0.196130010499874 929 5322297
SGTC_352 k048-0007 5.11 µM 0.852838300590774 0.208192430425682 no 754 0.196874490507454 1005 6811911
SGTC_944 3370-0224 231 µM 0.851705582115165 0.208497010040632 no 755 0.197188760817108 964 4580514
SGTC_2170 morpholine 200 µM 0.849149183852786 0.209185371506641 no 756 0.197899142667295 967 121171 Reacts with secondary amines.
SGTC_2072 5231554 129 µM 0.84864734937799 0.209320657431032 no 757 0.198038775682947 1073 789545
SGTC_1218 1348-1416 30.7 µM 0.848433878205201 0.20937822118702 no 758 0.198098191037143 992 6787668
SGTC_739 1486-1183 203 µM 0.847909844112709 0.209519569554849 no 759 0.198244090891132 1015 4346692
SGTC_263 alizarin 107.927 µM 0.846709233398288 0.209843623328042 no 760 0.198578605434857 1021 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium.
SGTC_972 1319-0219 195 µM 0.846518608242019 0.209895101565736 no 761 0.19863174877894 932 23903702
SGTC_583 1488-1091 88.9 µM 0.84588435263211 0.210066435432124 no 762 0.198808631166152 1119 4303273
SGTC_2921 7974240 10.71 µM 0.845664584062689 0.21012582150958 no 763 0.198869942779501 954 2979074 YDR527W RBA50
SGTC_3009 9080819 71.4286 µM 0.843487057271919 0.210714767680577 no 764 0.199478050637241 975 17027216
SGTC_724 3910-0327 137 µM 0.84344743810742 0.210725492264995 no 765 0.199489125256323 997 2885483
SGTC_2211 7117706 200 µM 0.842816690861303 0.210896273517422 no 766 0.199665485870745 958 822771
SGTC_945 3381-0768 11.3 µM 0.837220435668365 0.212415067517878 no 767 0.201234336311545 1029 1126236 YIL048W NEO1
SGTC_1668 st014914 51.6 µM 0.835967221553764 0.212756056917379 no 768 0.201586671742953 1011 2839556
SGTC_413 propylparaben 100 µM 0.835654458468267 0.212841207020067 no 769 0.201674661250418 950 7175 A pharmaceutical preservative.
SGTC_1972 st070201 17.4 µM 0.834996562346599 0.213020384895346 no 770 0.201859821961447 992 2829099
SGTC_787 4152-0075 138 µM 0.831665044307185 0.213929073358716 no 771 0.202799018307324 978 9566539
SGTC_2713 st079149 53.4 µM 0.831589524041714 0.213949698018154 no 772 0.202820338625732 993 3103253
SGTC_742 0kpi-0133 140 µM 0.830946897023657 0.214125246922625 no 773 0.203001814465979 1023 2728852
SGTC_1984 st072354 53.1 µM 0.828896708162291 0.214685864893954 no 774 0.203581429128895 986 5762938
SGTC_160 3453-0671 289.699 µM 0.823933113833639 0.216046671878326 no 775 0.204988781910795 1048 5322268
SGTC_3297 9117502 71.43 µM 0.821400135502455 0.216743028107555 no 776 0.205709193202991 1017 7453720
SGTC_2030 5175110 200 µM 0.820717180928971 0.216931005156538 no 777 0.205903691060464 1025 2831986
SGTC_765 1319-0117 244 µM 0.820132349403221 0.217092049599374 no 778 0.206070331240955 1022 3487746 YGL099W LSG1
SGTC_3318 9139014 38.6185 µM 0.819488529914015 0.217269417351941 no 779 0.206253871726567 975 16643984
SGTC_657 3534-0529 86.7 µM 0.819431464191129 0.217285142595185 no 780 0.206270144734173 1033 1049549
SGTC_939 1165-0479 45.3 µM 0.818561159867398 0.217525048339439 no 781 0.206518417232053 1008 1377347
SGTC_1242 0402-0103 60.1 µM 0.818326235712065 0.21758983309427 no 782 0.206585464585767 966 432868
SGTC_364 0083-0097 67.7 µM 0.816499117823072 0.218094075155393 no 783 0.20710736393872 1004 5207356
SGTC_860 0443-0016 25.1 µM 0.81427167897369 0.218709706618275 no 784 0.207744665167194 1076 5337942
SGTC_2910 7948405 25.97 µM 0.814147011137361 0.218744192512445 no 785 0.207780368567425 1003 2971328
SGTC_1255 0566-0045 221 µM 0.811777234697079 0.219400320204951 no 786 0.208459733596726 1013 2788469
SGTC_2691 st077356 60.2 µM 0.81012703537884 0.219857883367282 no 787 0.208933583733149 1045 2839272
SGTC_1974 st069448 26.9 µM 0.808999757101301 0.220170766888795 no 788 0.20925764299457 1036 6323587 YNR016C ACC1
SGTC_1574 spiramycin 23.7 µM 0.807865932295034 0.220485724880372 no 789 0.209583882436617 1066 6419898 An antibiotic and protein synthesis inhibitor.
SGTC_1852 st056254 31.4 µM 0.8077673387966 0.220513124738852 no 790 0.209612265225294 1009 442583
SGTC_1711 st032263 62.8 µM 0.80776256339032 0.220514451908925 no 791 0.209613640011749 994 3958979
SGTC_1888 azatryptophan 97.5 µM 0.805776352648896 0.22106685181767 no 792 0.210185907708202 934 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides
SGTC_630 4356-0227 183 µM 0.804564727666614 0.221404214395884 no 793 0.210535451671926 1029 779312
SGTC_767 0929-0023 86 µM 0.803591499508103 0.221675411272465 no 794 0.210816466992904 1110 1204563
SGTC_973 1325-0077 65.9 µM 0.798284209721079 0.223157660628325 no 795 0.212352789578905 1086 2835149
SGTC_1032 k061-1018 98.7 µM 0.797719381549192 0.22331574050689 no 796 0.212516676976731 1123 4005393
SGTC_974 1326-0144 138 µM 0.797332253056653 0.223424123927597 no 797 0.212629046685913 1059 5411856
SGTC_276 colchicine 750 µM 0.796716917300202 0.223596459555665 no 798 0.212807728282274 1067 2833 A microtubule depolymerizer.
SGTC_2963 9082507 9 µM 0.796389956943191 0.223688061316148 no 799 0.212902706892168 988 16459611
SGTC_2012 4023501 200 µM 0.795152481883677 0.224034947532397 no 800 0.213262404559946 991 3477460
SGTC_1252 0493-0875 34.8 µM 0.794736436811542 0.224151640954511 no 801 0.213383416197401 1017 3960963
SGTC_171 k064-0041 9.68 µM 0.790801656293836 0.225256984213147 no 802 0.214529871629904 975 53325
SGTC_3057 9095946 49.47 µM 0.790499642695449 0.225341952078247 no 803 0.214618015404608 1103 24540043
SGTC_2188 6126565 140.678 µM 0.789948459561937 0.225497067546017 no 804 0.214778934472743 1007 874518
SGTC_3004 9076122 71.4286 µM 0.789096710962387 0.225736887787418 no 805 0.215027742073838 1049 44782551
SGTC_521 r062-0005 13.8 µM 0.788381734263449 0.225938309565852 no 806 0.215236725851763 1001 2832033
SGTC_671 0560-0003 407 µM 0.788341609072358 0.225949616563564 no 807 0.215248457717982 1020 3238678
SGTC_2946 9065502 71.43 µM 0.788314082224383 0.225957373621474 no 808 0.215256506275532 892 16489101
SGTC_488 nitrendipine 139 µM 0.786339201354673 0.226514287232266 no 809 0.215834396045432 1074 4507 Dihydropyridine L-type calcium channel blocker.
SGTC_2885 9057732 51.95 µM 0.785818899930411 0.226661140374786 no 810 0.215986796196001 1084 6471414
SGTC_3284 9108171 64.8615 µM 0.784940319569151 0.226909238346273 no 811 0.216244280372505 995 8687505
SGTC_1379 2144-0755 36.5 µM 0.78331601582154 0.227368320570312 no 812 0.216720780253196 1113 5392327
SGTC_265 mycophenolic acid 32.932 µM 0.783043393564045 0.227445423932058 no 813 0.216800815202496 1132 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1
SGTC_1015 4130-4525 82 µM 0.781335483162817 0.227928792252594 no 814 0.217302602929429 1068 1363237
SGTC_3338 9144300 39.5675 µM 0.779049715889378 0.228576607472158 no 815 0.217975214612696 1069 4901274
SGTC_754 3474-0146 171 µM 0.779003213583156 0.228589797535784 no 816 0.217988910865232 1034 24762078
SGTC_2149 5554786 194.827 µM 0.777377338406817 0.229051234673286 no 817 0.218468089226758 1111 745063 YPR165W RHO1
SGTC_1298 1079-1278 263 µM 0.775683356924547 0.229532556296812 no 818 0.218967984524857 1106 2840950
SGTC_1912 st060209 90.8 µM 0.775331610715579 0.229632571169417 no 819 0.219071867544435 1040 688787
SGTC_999 SEC7.066 22.7 µM 0.775284467989481 0.229645977500689 no 820 0.219085792601927 1104 740511 YDR170C SEC7
SGTC_2258 7960471 200 µM 0.77495254098219 0.229740382487558 no 821 0.219183851882947 1025 2974708
SGTC_728 3030-5151 22.5 µM 0.774652293313645 0.229825796116243 no 822 0.219272574049988 1044 3125388
SGTC_1977 st070720 65.3 µM 0.773924046288023 0.230033039664043 no 823 0.219487854303616 1023 682188
SGTC_3082 9117008 49.47 µM 0.773687427095589 0.230100398934724 no 824 0.219557828452535 1055 41448529
SGTC_169 k015-0017 16.025 µM 0.773319243058045 0.230205233204603 no 825 0.219666735056985 1063 1840002
SGTC_3065 9113888 49.47 µM 0.773013641885997 0.230292268332888 no 826 0.219757153583332 1045 16648368
SGTC_1329 1447-1697 50.6 µM 0.77129862532954 0.230781045827589 no 827 0.220264973496679 1047 2840515
SGTC_3341 9147222 25.867 µM 0.770845969374295 0.230910148767595 no 828 0.220399117996484 1030 1939759
SGTC_2716 st080858 38.6235 µM 0.770477627660074 0.231015234019853 no 829 0.220508310535748 1089 5296050
SGTC_3054 9094397 49.47 µM 0.767620990352746 0.231831117869841 no 830 0.221356194128291 1115 2598354
SGTC_879 0831-1030 162 µM 0.765620209899011 0.232403515001648 no 831 0.221951157852546 1094 1549252
SGTC_1249 0481-0015 10.2 µM 0.763363245268215 0.233050145497361 no 832 0.222623396685543 1077 4227577
SGTC_638 3970-0837 4.09 µM 0.763028808171318 0.233146048142823 no 833 0.222723107704103 1098 4118451 YLR208W SEC13
SGTC_3098 9119039 49.47 µM 0.762926250505725 0.23317546180336 no 834 0.222753689940882 1133 17161528
SGTC_2068 5226020 147 µM 0.762181304811193 0.233389174926603 no 835 0.222975901222369 1159 1810509
SGTC_1625 st003711 30.1 µM 0.762060992485216 0.233423700817741 no 836 0.22301180125563 1112 24207034 YER133W GLC7
SGTC_861 0443-0273 110 µM 0.761783621419235 0.233503308471461 no 837 0.223094578637864 1095 6149169
SGTC_936 3005-4620 401 µM 0.761772437320764 0.233506518710529 no 838 0.223097916737167 1113 777207
SGTC_2707 st078556 66.6 µM 0.761514773476115 0.233580484291851 no 839 0.22317482911183 1060 17250899
SGTC_1226 3909-7979 35.4 µM 0.760915051226259 0.233752692254911 no 840 0.223353903987862 1110 6615510
SGTC_397 arbidol 50 µM 0.758454957273188 0.234459834766303 no 841 0.224089334109693 1120 131410 A RNA synthesis inhibitor.
SGTC_1871 st057448 67.3 µM 0.757825509382811 0.234640956594376 no 842 0.224277724475467 1139 691747
SGTC_1201 1889-3372 45.9 µM 0.757456704070309 0.234747115206214 no 843 0.224388147684389 1057 5392199
SGTC_1346 1488-2224 62.4 µM 0.757246522913963 0.234807626590177 no 844 0.224451091375881 1107 3722427
SGTC_466 geldanamycin 89.2 µM 0.756159832864018 0.235120623331386 no 845 0.224776686057489 1004 5288382 HSP90 inhibitor.
SGTC_1273 0849-0096 14.1 µM 0.754706222117416 0.235539663412446 no 846 0.225212636167244 1094 5286025
SGTC_1397 3532-0190 20.1 µM 0.754586289158841 0.235574255513581 no 847 0.22524862644678 1038 5322280
SGTC_1589 2',5'-dimethoxyflavone 47.2 µM 0.752867650110071 0.236070267970195 no 848 0.225764724744683 1084 688667
SGTC_1846 st056244 14.8 µM 0.752497815131497 0.236177080375303 no 849 0.22587587164122 1101 5393182
SGTC_1316 1272-0050 65.9 µM 0.752264694310658 0.236244421905102 no 850 0.225945947584161 1106 7340392
SGTC_1271 0832-2808 169 µM 0.749981260741866 0.23690459529621 no 851 0.226632995508598 1139 3663794
SGTC_1339 1486-1321 22.7 µM 0.748456297543624 0.237346048238132 no 852 0.227092487995575 1099 3469382
SGTC_2114 5491910 81.25 µM 0.748390804898707 0.237365017443304 no 853 0.227112233590124 1114 2849228
SGTC_2653 dihydrofissinolide 100 µM 0.748310535085658 0.237388267823729 no 854 0.227136435722093 1127 6857746
SGTC_599 1935-0052 86.5 µM 0.746755920960888 0.237838812777157 no 855 0.227605453700599 1136 9557311
SGTC_1926 methyl fluorone black 53.6 µM 0.746440890899399 0.237930169200285 no 856 0.22770056282808 1005 72721 Reacts with homocysteine.
SGTC_3173 9105693 49.47 µM 0.745632893521834 0.238164570484554 no 857 0.227944603462367 1170 17096658
SGTC_2027 5150920 200 µM 0.744781695028787 0.238411641277567 no 858 0.228201851268326 1121 786715
SGTC_1944 st076371 56.9 µM 0.743023377237295 0.238922458670772 no 859 0.228733763633314 1104 24208455
SGTC_3181 9108277 49.47 µM 0.742071325226674 0.239199293463322 no 860 0.229022061104098 1103 17097298
SGTC_2931 9014674 55.67 µM 0.740844155838943 0.239556384471532 no 861 0.229393969335306 1135 2996810
SGTC_700 3453-2283 142 µM 0.74072311391994 0.239591621923866 no 862 0.229430670856121 1157 565664
SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM 0.740214786849606 0.239739635848706 no 863 0.229584838315214 1117 4330530
SGTC_2024 5144227 134 µM 0.738976676211174 0.240100355742537 no 864 0.229960580163074 1127 3475211
SGTC_1203 3992-3522 103 µM 0.738666216187068 0.240190853732585 no 865 0.230054852523731 1194 5322312
SGTC_1993 st073995 70.8 µM 0.736192498489617 0.240912597372137 no 866 0.23080677840778 1134 3098394
SGTC_2084 5306078 60.6385 µM 0.736115657302099 0.240935035798442 no 867 0.230830157470019 1089 679340
SGTC_674 0498-0004 451 µM 0.735758596616294 0.241039316145837 no 868 0.23093881114091 1102 4231473
SGTC_3222 9128301 49.47 µM 0.735662729294399 0.241067318583781 no 869 0.23096798845664 1182 4911358
SGTC_651 3253-0966 34.4 µM 0.735229154186253 0.241193986120431 no 870 0.231099973173913 1158 781462
SGTC_3112 9123419 49.47 µM 0.734630458339411 0.24136895258546 no 871 0.231282291508586 1193 17015854
SGTC_2414 st077232 92.9 µM 0.734263030410935 0.241476366063308 no 872 0.231394222511995 1067 729801
SGTC_1779 st039427 55 µM 0.734177697036989 0.24150131604278 no 873 0.231420222272513 1192 1124498
SGTC_2570 licareol 100 µM 0.733189184604379 0.241790441734051 no 874 0.231721525444006 1080 443158
SGTC_2455 5377712 9.75 µM 0.731509922678327 0.242282032024852 no 875 0.232233872953399 1099 2243908
SGTC_2238 6671620 73.2395 µM 0.731343958943554 0.242330645955661 no 876 0.232284543159178 1142 729941
SGTC_2008 4012253 172 µM 0.729228686974056 0.242950712063156 no 877 0.232930893058544 1160 603940
SGTC_294 k038-0071 157 µM 0.727967444941803 0.243320837810137 no 878 0.23331675749973 1147 24152826
SGTC_2141 5621638 7.665 µM 0.727468676117498 0.243467291207464 no 879 0.233469448669702 1145 2856238
SGTC_3171 9103192 49.47 µM 0.725988651613923 0.243902150698382 no 880 0.233922863783274 1202 13018434
SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM 0.725930004481388 0.243919390975596 no 881 0.23394084075655 1163 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_323 4013-0906 34.3 µM 0.724123861255798 0.244450657916835 no 882 0.234494848360328 1173 2910086
SGTC_145 3737-0113 38.366 µM 0.721740492354644 0.245152665645652 no 883 0.235227020872198 1224 6849351
SGTC_3305 9127027 53.8275 µM 0.721697686388498 0.245165283802068 no 884 0.235240182422638 1108 41905295
SGTC_2995 9067767 71.4286 µM 0.719356964004449 0.245855803157251 no 885 0.235960503040652 1137 11673567
SGTC_1862 st057513 3.81 µM 0.715821000716474 0.246900898168702 no 886 0.237050941642862 1169 5393163
SGTC_3114 9122766 49.47 µM 0.715440678889401 0.247013448151979 no 887 0.237168391973009 1111 17176985
SGTC_2328 6201408 200 µM 0.715172392578116 0.247092859577843 no 888 0.237251262914947 1118 2890418
SGTC_2589 lobaric acid 100 µM 0.714907860754698 0.247171173062833 no 889 0.237332989703177 1172 73157 A novel microtubule depolymerizer.
SGTC_2207 7258803 200 µM 0.711127043283921 0.248291916672427 no 890 0.238502756580622 1131 3666799
SGTC_1735 st034310 56.75 µM 0.710672892897292 0.248426722012702 no 891 0.238643480573056 1150 871153
SGTC_425 3825-7017 13.1 µM 0.71012100216872 0.248590592081275 no 892 0.238814551734746 1181 3397440
SGTC_1859 st055998 20 µM 0.709196664553089 0.248865179818271 no 893 0.239101221528519 1194 676301
SGTC_2504 purpurogallin 52.29 µM 0.708398228059979 0.249102496722041 no 894 0.239348996255742 1105 5281571 An antioxidant.
SGTC_676 falcarinol 140 µM 0.707775249826304 0.249287746264845 no 895 0.239542419279649 1208 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer.
SGTC_1667 st014849 34.6 µM 0.707217287002151 0.249453724907775 no 896 0.239715728658113 1215 5348460
SGTC_1778 st046819 58.9 µM 0.706503195326963 0.249666233252804 no 897 0.239937633157552 1229 671715
SGTC_3027 9089541 49.47 µM 0.706272682772926 0.249734852589117 no 898 0.240009289009914 1179 9943819
SGTC_1173 0443-0020 122 µM 0.704037560081497 0.250400726413891 no 899 0.240704691562709 1179 5331295
SGTC_1194 1488-0194 225 µM 0.703677000726181 0.250508230089027 no 900 0.240816973220799 1166 1391452
SGTC_872 0588-0139 234 µM 0.700859994279952 0.251348984499903 no 901 0.241695196472332 1209 2047100
SGTC_901 1112-0062 60.1 µM 0.69912684598438 0.251866994420085 no 902 0.242236381302817 1210 1908457
SGTC_694 1315-0438 43.2 µM 0.699049594907512 0.251890096626038 no 903 0.242260518646036 1118 6793154
SGTC_943 3253-1379 105 µM 0.6940184212551 0.253397092087412 no 904 0.243835328282101 1191 668464
SGTC_377 3970-0964 33.1 µM 0.693155991468888 0.253655891998517 no 905 0.244105831388625 1204 16481235
SGTC_3021 9087658 49.47 µM 0.692032468775927 0.253993249375717 no 906 0.24445846949812 1186 25237042
SGTC_1265 0819-1001 68.8 µM 0.691665287986909 0.254103552861672 no 907 0.244573775371792 1211 3106768
SGTC_1827 berberine 7.24 µM 0.688210796247173 0.255142533487178 no 908 0.245660023085738 1140 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_426 0988-0037 14.6 µM 0.687663727044251 0.255307274782906 no 909 0.245832283596812 1225 5383008
SGTC_61 0978-8327 98.565 µM 0.687660151549751 0.255308351669767 no 910 0.245833409657566 1235 6150059 YHR072W ERG7
SGTC_3164 9100705 49.47 µM 0.686534873371994 0.255647386994652 no 911 0.24618794055371 1204 17174235
SGTC_2936 9038235 15.59 µM 0.685940027548485 0.255826703179874 no 912 0.246375463795062 1222 4749415
SGTC_410 α-linolenic acid 100 µM 0.685239935844807 0.256037829790187 no 913 0.246596263499584 1254 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_1382 3002-2117 298 µM 0.684939660953694 0.25612841151368 no 914 0.2466909987163 1251 1497314
SGTC_1742 st038235 28.8875 µM 0.682074511096934 0.256993560044057 no 915 0.247595918452088 1192 564103 YBR002C RER2
SGTC_344 k064-0035 6.43 µM 0.681018644373562 0.257312768005223 no 916 0.247929846592206 1189 5088750
SGTC_126 0417-1624 672.48 µM 0.680738986610501 0.25739734820266 no 917 0.248018331328436 1313 41912 YDL195W SEC31
SGTC_2868 9035608 32.47 µM 0.679049604005624 0.257908595170206 no 918 0.248553216288076 1220 6462614
SGTC_1161 k007-0610 110 µM 0.677885222865827 0.258261270781134 no 919 0.248922235030469 1257 5843850
SGTC_2874 9043904 71.43 µM 0.676957538497596 0.258542432878305 no 920 0.249216447778494 1172 4463428
SGTC_31 0508-1974 57.237 µM 0.675287419403421 0.259049010998648 no 921 0.249746587616574 1198 6810525
SGTC_1012 4112-3522 18 µM 0.674594880628624 0.259259221309111 no 922 0.249966593195966 1230 3112398
SGTC_1041 0206-0046 107 µM 0.673352910844931 0.259636424286496 no 923 0.250361399375242 1231 50494
SGTC_1306 1185-0270 9.02 µM 0.672200654005763 0.259986633412425 no 924 0.250727982353921 1229 1548076
SGTC_729 4092-0585 94.1 µM 0.67058937220994 0.260476763654903 no 925 0.251241077379604 1219 2169061
SGTC_539 4859-0462 2.54 µM 0.669734836905964 0.260736894754742 no 926 0.25151341992823 1239 46499474 YNL221C | YBR257W POP1 | POP4
SGTC_1043 0916-0009 19.3 µM 0.668346172494819 0.261159906294004 no 927 0.251956323259707 1277 3101130
SGTC_2415 st077333 57.7 µM 0.667993611781702 0.261267358583924 no 928 0.252068835138435 1288 2766255
SGTC_1555 citronellol 128 µM 0.667949781382106 0.261280718655621 no 929 0.252082824483938 1221 8842 A terpine precursor.
SGTC_984 1492-0255 2.91 µM 0.667543845817632 0.261404469732604 no 930 0.252212406368983 1190 1585198
SGTC_26 0302-0163 425.158 µM 0.667025392622058 0.261562566019441 no 931 0.252377956959958 1253 3100915
SGTC_2804 7954240 19.48 µM 0.666095200234407 0.261846340372888 no 932 0.252675126127867 1240 828705
SGTC_590 k048-0076 22.4 µM 0.66361308107819 0.262604334045954 no 933 0.25346899141409 1249 6832814
SGTC_3329 9141233 27.5565 µM 0.66304263892347 0.262778695168315 no 934 0.253651623068036 1245 4909101 YNL103W MET4
SGTC_2431 5490079 200 µM 0.66278398064402 0.262857776062664 no 935 0.253734457369399 1267 5722345
SGTC_1410 3909-8106 77.9 µM 0.661908444432088 0.263125548428199 no 936 0.254014949791394 1273 1039210
SGTC_740 k014-0057 261 µM 0.661531290926196 0.263240939290039 no 937 0.2541358272331 1263 4012779
SGTC_2606 farnesol 9.78 µM 0.658393817554684 0.264201856287729 no 938 0.255142553519674 1280 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_834 0312-0008 75.7 µM 0.658081783269652 0.264297520908584 no 939 0.255242790384482 1271 6385573 YIL048W NEO1
SGTC_2138 5575593 77.673 µM 0.657169188626164 0.264577408721812 no 940 0.255536067399521 1251 762213
SGTC_2283 7944793 200 µM 0.655661335166446 0.265040189341963 no 941 0.256021025881666 1234 2970533
SGTC_1455 4262-0120 131 µM 0.654714878534145 0.265330879609725 no 942 0.256325672010108 1332 1529587
SGTC_1967 st070177 51.4 µM 0.654437181021659 0.265416201022599 no 943 0.256415093319359 1315 5729214
SGTC_1650 st011916 45.8 µM 0.654185490160931 0.265493544025395 no 944 0.25649615427372 1246 242528
SGTC_2225 6654152 15.4 µM 0.653081931331678 0.265832795566884 no 945 0.256851730078085 1220 97582 YGR029W | YLR033W ERV1 | RSC58
SGTC_2474 5321570 43.32 µM 0.652836442338239 0.265908292651166 no 946 0.256930863532889 1275 2841384
SGTC_3132 9126706 49.47 µM 0.652207567711801 0.26610174476607 no 947 0.257133639323439 1275 850858
SGTC_3040 9091894 49.47 µM 0.650869223720161 0.266513678351881 no 948 0.257565454897349 1201 25236966
SGTC_2094 5332512 191.667 µM 0.650699024732814 0.26656608760108 no 949 0.257620396439184 1315 755774
SGTC_1746 st038117 42 µM 0.650435677110686 0.266647190310538 no 950 0.25770541906802 1279 2898218
SGTC_1416 3966-0321 25.3 µM 0.649797560715407 0.266843761631618 no 951 0.257911497400723 1269 582530 YLR208W SEC13
SGTC_2556 citropten 84.59 µM 0.648715930195084 0.267177124332969 no 952 0.25826100286653 1257 2775 A potential DNA crosslinker.
SGTC_2115 tiliquinol 12.7705 µM 0.647878033671219 0.267435511693682 no 953 0.258531919615531 1270 71208 A bioactive hydroxyquinoline.
SGTC_846 0335-0850 148 µM 0.647854505932447 0.267442768907521 no 954 0.258539528953805 1249 6819598
SGTC_615 k087-0205 167 µM 0.646218862787201 0.267947532136233 no 955 0.259068812627622 1239 9642773
SGTC_2180 6301957 200 µM 0.644917288087604 0.268349543563858 no 956 0.259490393856797 1240 845462
SGTC_815 1582-0027 36.9 µM 0.644640614569652 0.268435037528006 no 957 0.259580054300943 1308 3128206
SGTC_3355 9151058 44.0485 µM 0.644460267219636 0.268490773435632 no 958 0.259638507332025 1271 17015728
SGTC_3246 9135460 32.98 µM 0.641062019958837 0.26954207989028 no 959 0.260741194441482 1225 41446951
SGTC_687 k029-0044 34.9 µM 0.640731720570594 0.269644373596834 no 960 0.26084850065386 1302 5829338
SGTC_3193 9111931 49.47 µM 0.640133967530749 0.269829547119719 no 961 0.261042753770956 1330 17087244
SGTC_339 3091-4833 71.4 µM 0.63748665257044 0.27065040399594 no 962 0.26190395067507 1255 3240077
SGTC_2109 5483026 200 µM 0.637279602678415 0.270714656807151 no 963 0.261971367366093 1312 759335
SGTC_542 3381-0244 89.3 µM 0.637217082761955 0.270734059813377 no 964 0.261991725975943 1298 1112843
SGTC_155 k072-0202 43.6 µM 0.636640645724541 0.27091298929525 no 965 0.262179471676024 1236 5857737
SGTC_3019 9081971 49.47 µM 0.636100415763678 0.271080733434693 no 966 0.262355487277476 1332 16451803
SGTC_1721 st082152 9.2685 µM 0.634286971458805 0.271644195600327 no 967 0.262946778771614 1243 5296051
SGTC_2551 apiole 73.87 µM 0.634218251256584 0.271665559376847 no 968 0.262969199064912 1198 10659 A possible DNA adduct former.
SGTC_402 epigallocatechin gallate 10 µM 0.633330255438474 0.271941695249601 no 969 0.263258999803553 1271 65064 An antioxidant.
SGTC_2023 5144124 124 µM 0.633111097378413 0.272009867272161 no 970 0.263330547939843 1276 2830192
SGTC_1578 josamycin 24.2 µM 0.632542064779476 0.272186912083902 no 971 0.263516365334432 1219 5282165 A P450 substrate.
SGTC_2727 riluzole 51.77 µM 0.630943494556129 0.27268458626587 no 972 0.264038735690814 1290 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.
SGTC_1628 st004252 77.7 µM 0.627767147845749 0.273674799179529 no 973 0.265078245075054 1322 692968
SGTC_3243 9134147 49.47 µM 0.626988165380086 0.273917915080971 no 974 0.265333496394508 1346 24282180
SGTC_2634 4'-methoxyflavone 100 µM 0.626891768031783 0.273948007554863 no 975 0.265365091850093 1299 77793 From seeds of Psoralea corylifolia (Fabaceae)
SGTC_2787 5284540 71.43 µM 0.625097054701852 0.274508563568277 no 976 0.265953680449753 1327 736958
SGTC_574 1315-0397 40 µM 0.621665221732403 0.27558202652244 no 977 0.267081012312009 1310 6794277
SGTC_1234 0326-0494 15.5 µM 0.618479625407618 0.276580311547675 no 978 0.268129612166018 1366 1547813
SGTC_1448 4255-0083 152 µM 0.617829216629567 0.276784350841176 no 979 0.268343961067108 1405 5399660
SGTC_1895 st058434 18.3 µM 0.617252797880184 0.276965240382483 no 980 0.26853399780341 1311 5393175
SGTC_1494 4358-1428 177 µM 0.616452591402689 0.277216454042818 no 981 0.268797926141075 1387 1564571
SGTC_391 gliotoxin 8.33 µM 0.613242103884061 0.278225461061269 no 982 0.269858134410912 1369 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion
SGTC_3347 9188721 44.724 µM 0.613100343512044 0.278270055421509 no 983 0.269904996551035 1310 44118411 YKL104C | YBL026W GFA1 | LSM2
SGTC_1100 amiodarone 5.07 µM 0.607148960632624 0.280145352887773 no 984 0.27187603020798 1362 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death.
SGTC_2343 7990716 14.84 µM 0.605603534108534 0.280633320816981 no 985 0.272389027489405 1339 6456862
SGTC_2748 diazoxide 86.69 µM 0.605419733197971 0.280691383245665 no 986 0.272450071339544 1324 3019 A potassium channel activatior.
SGTC_1522 st012842 45.6 µM 0.6042420277468 0.281063556447381 no 987 0.272841371337759 1263 3491067 YOR116C RPO31
SGTC_685 1278-0033 54.9 µM 0.604029151168522 0.281130854182736 no 988 0.272912130647438 1413 3590572
SGTC_2208 7283366 200 µM 0.603572003937951 0.28127540071691 no 989 0.273064115277709 1358 898663
SGTC_2260 7964312 200 µM 0.603359619332694 0.281342567345078 no 990 0.273134739613131 1383 231951
SGTC_779 1360-0071 233 µM 0.59905640071448 0.282705125010694 no 991 0.274567637226318 1461 7566
SGTC_516 3992-2719 87.3 µM 0.598925709342451 0.282746556281678 no 992 0.274611213156123 1271 5350887 YDR037W KRS1
SGTC_613 3914-0030 117 µM 0.597921372616596 0.283065044519619 no 993 0.274946199143077 1194 1145395
SGTC_83 0170-0301 39.027 µM 0.596335712897445 0.283568228070592 no 994 0.275475488873984 1309 3089716
SGTC_3290 9121031 71.43 µM 0.593705682593852 0.284403769513041 no 995 0.276354490820929 1323 17014854
SGTC_3100 9120536 49.47 µM 0.590966577542382 0.285275211777331 no 996 0.277271407624006 1279 16421196
SGTC_1020 4335-0961 93.3 µM 0.590148056709585 0.285535869638622 no 997 0.277545696357958 1297 669075
SGTC_923 1900-2434 73.3 µM 0.589938225879319 0.285602708493049 no 998 0.277616032631456 1316 5910570
SGTC_1313 1220-0047 237 µM 0.589001708570712 0.28590111451958 no 999 0.277930063731509 1408 3528706
SGTC_1698 5-fluorocytosine 1.055 µM 0.588633773815338 0.286018391495887 no 1000 0.278053486292664 1388 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_764 1951-2361 146 µM 0.588542529829076 0.286047478501626 no 1001 0.278084097939333 1310 5438930
SGTC_2905 7799065 20.05 µM 0.587028283990035 0.28653039900798 no 1002 0.278592355516104 1342 1296806
SGTC_450 aminopyrene 156 nM 0.586978228543845 0.286546369201065 no 1003 0.278609164380168 1366 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1
SGTC_832 4083-0019 164 µM 0.586345337139127 0.286748329654435 no 1004 0.278821735004517 1464 1990758
SGTC_3022 9087993 49.47 µM 0.584419032116231 0.287363443112017 no 1005 0.279469212582986 1423 17173644
SGTC_2123 5259487 200 µM 0.582722837197503 0.287905593413516 no 1006 0.280039948498583 1377 2173474
SGTC_1320 1313-0481 95.3 µM 0.581292642505384 0.288363097744036 no 1007 0.280521619238364 1373 6813365 YLR208W SEC13
SGTC_708 3448-5400 146 µM 0.581279202751881 0.28836739860583 no 1008 0.280526147471374 1353 3462195
SGTC_3204 9114183 49.47 µM 0.581060240873515 0.288437472958419 no 1009 0.280599926902813 1384 17027248
SGTC_1176 0848-0131 83.3 µM 0.580572074600745 0.288593729659663 no 1010 0.280764448824914 1420 6769040
SGTC_2924 9010168 62.78 µM 0.580169758405114 0.288722536654942 no 1011 0.280900072587126 1376 2993929
SGTC_3292 9120825 59.784 µM 0.57775136740631 0.289497387272338 no 1012 0.281715996706423 1400 24824900
SGTC_3101 9120531 49.47 µM 0.577352864267557 0.289625161033719 no 1013 0.281850554475103 1428 24824904
SGTC_1321 1326-2144 215 µM 0.57720354965012 0.289673043233552 no 1014 0.28190097972342 1386 3513030
SGTC_1345 1488-0192 31.4 µM 0.575493035335039 0.290221835726594 no 1015 0.282478949791255 1372 658348
SGTC_1384 3089-0840 101 µM 0.574530409984402 0.290530893454493 no 1016 0.2828044641236 1408 1069836
SGTC_3111 9122088 49.47 µM 0.573042839724512 0.291008791152188 no 1017 0.283307844061829 1302 16876704
SGTC_665 3914-0008 307 µM 0.569420306559997 0.292174101793662 no 1018 0.284535469657442 1328 1069549
SGTC_2227 7312221 64.1025 µM 0.568473221209377 0.292479121570632 no 1019 0.28485684201651 1403 887188 YOR168W | YOR169C GLN4 | YOR169C
SGTC_1117 retinoic acid 1.10837 µM 0.567279945322088 0.292863640436422 no 1020 0.285262000039047 1481 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR).
SGTC_1804 st050076 49.1 µM 0.566931058984332 0.292976109198417 no 1021 0.285380510748005 1409 3895976
SGTC_1036 k216-0215 33.5 µM 0.566672737444894 0.293059395945103 no 1022 0.285468273252614 1371 622330
SGTC_3029 9088683 49.47 µM 0.564715867855517 0.29369067653605 no 1023 0.28613351976243 1395 25236615
SGTC_3354 9151612 71.43 µM 0.564271761603437 0.293834031535426 no 1024 0.286284598126274 1441 27261949
SGTC_1571 st070080 73.4 µM 0.563417585995166 0.294109845579637 no 1025 0.286575282438593 1489 4315245
SGTC_1732 st034308 51.822 µM 0.563342769213125 0.294134009681387 no 1026 0.28660074998809 1371 830119
SGTC_311 1315-0136 58 µM 0.563202821584841 0.294179212013061 no 1027 0.28664839088705 1445 6759207
SGTC_1665 st014639 11.4 µM 0.561206254487526 0.294824441688734 no 1028 0.287328469851291 1452 981133 YIL048W NEO1
SGTC_1473 k844-0725 134 µM 0.560589449569335 0.295023906073978 no 1029 0.28753872274284 1429 54682906
SGTC_970 1315-0089 19.5 µM 0.56011879934863 0.295176148278779 no 1030 0.287699204179268 1328 6811083 YLR033W RSC58
SGTC_1601 4'-hydroxyflavanone 55.5 µM 0.559155758491134 0.295487777779463 no 1031 0.288027711898634 1478 165506
SGTC_2053 5265679 138 µM 0.55826461666442 0.295776276250528 no 1032 0.288331851405101 1356 764595
SGTC_3053 9095903 49.47 µM 0.556464166265767 0.296359548990502 no 1033 0.288946792188066 1452 17174018
SGTC_535 2293-4129 48.2 µM 0.555616393391708 0.29663437543055 no 1034 0.289236561118114 1451 396118 YIL048W NEO1
SGTC_2799 7812892 81.82 µM 0.553535627712991 0.297309401169382 no 1035 0.289948345681324 1444 20205235
SGTC_601 0986-0029 62.9 µM 0.551687652376351 0.297909494683968 no 1036 0.290581185577638 1410 24747981
SGTC_2596 sinensetin 100 µM 0.548643827655564 0.298899118638213 no 1037 0.291624951115173 1391 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets.
SGTC_1550 gossypolone 36.6 µM 0.547009713063961 0.299431025745963 no 1038 0.292186029548848 1397 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_2041 5107442 45.335 µM 0.546081633274975 0.299733308275736 no 1039 0.292504912166013 1442 793005
SGTC_1607 st000305 50.6 µM 0.545755739921266 0.299839486956528 no 1040 0.292616925514766 1459 5457690
SGTC_2918 7977171 22.06 µM 0.543417913196503 0.300601668445202 no 1041 0.293421047457279 1383 2236483
SGTC_139 0099-0334 718.624 µM 0.542981191161989 0.300744146071446 no 1042 0.293571376348283 1444 97690
SGTC_2251 lansoprazole 556 µM 0.542619245756977 0.300862251412712 no 1043 0.293695992572705 1349 3883 Gastric proton pump inhibitor. YBR192W RIM2
SGTC_435 c-PAF 6.7 µM 0.542595500959215 0.300870000239047 no 1044 0.293704168658696 1395 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase
SGTC_660 4031-1742 102 µM 0.541645970697303 0.301179941646576 no 1045 0.294031208301487 1388 6738706
SGTC_1140 3229-1848 2.98 µM 0.538492496989082 0.302210314927323 no 1046 0.295118541829292 1440 2849525
SGTC_2656 pseudo-anisatin 100 µM 0.538273377488903 0.30228196928715 no 1047 0.295194164084108 1431 6708809 A neurotoxin.
SGTC_208 k072-0098 12.366 µM 0.53650624878766 0.302860117185714 no 1048 0.295804359203763 1413 5948901
SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM 0.535457175097395 0.303203574508329 no 1049 0.296166881540283 1401 689007
SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM 0.534780286139361 0.303425274282626 no 1050 0.296400898283281 1409 4620898
SGTC_2904 7225135 42.03 µM 0.532828544838563 0.304064928392969 no 1051 0.29707613613665 1486 4446116
SGTC_1882 5615643 20 µM 0.532702359883574 0.304106304308007 no 1052 0.297119816151879 1375 2253075
SGTC_366 0181-0206 4.31 µM 0.531992790025271 0.304339018231892 no 1053 0.297365494569317 1554 274874
SGTC_2355 9061122 103.12 µM 0.531580871779234 0.304474149274237 no 1054 0.297508157931257 1488 5302957
SGTC_881 0833-0569 170 µM 0.531530253783885 0.304490756504677 no 1055 0.297525691074001 1385 5418700
SGTC_2794 7785382 27.27 µM 0.531292303621587 0.304568830844016 no 1056 0.297608118954988 1447 2205081
SGTC_738 1315-0003 72.4 µM 0.531288515209973 0.304570073939915 no 1057 0.297609431376022 1495 6251474
SGTC_1757 st041620 31.8375 µM 0.529807096005063 0.305056346635432 no 1058 0.298122842401488 1407 5289815
SGTC_1533 dihydroergotamine mesylate 29.4 µM 0.527519877493021 0.305807797413299 no 1059 0.298916308252678 1468 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release.
SGTC_749 1000-0129 128 µM 0.527067372549705 0.305956562037252 no 1060 0.299073401704795 1553 708470
SGTC_2563 tomatine 8.54 µM 0.526892956103785 0.306013911390487 no 1061 0.29913396283225 1537 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties.
SGTC_1658 st012944 20 µM 0.526887110038301 0.306015833700281 no 1062 0.299135992807867 1413 24207260
SGTC_805 3852-0218 479 µM 0.526125225094497 0.306266403262852 no 1063 0.299400601639646 1398 6615355
SGTC_295 k015-0027 31 µM 0.526020747868616 0.306300770917955 no 1064 0.29943689570309 1428 3887424
SGTC_808 0711-0032 135 µM 0.525816872364587 0.306367840422162 no 1065 0.299507725211641 1491 4252555
SGTC_3234 9132280 49.47 µM 0.525589522198959 0.306442640104116 no 1066 0.299586719136438 1424 17612295
SGTC_3033 9090887 49.47 µM 0.525456084384134 0.306486545768734 no 1067 0.299633087152875 1400 19325384
SGTC_2396 5342950 42.78 µM 0.525446233946434 0.306489787014161 no 1068 0.299636510188946 1458 1886677
SGTC_3252 9135871 49.47 µM 0.522058112269288 0.307605530994478 no 1069 0.300814934999722 1467 17682838
SGTC_2210 7115885 190.385 µM 0.521551961313391 0.307772365052412 no 1070 0.300991159044544 1439 2927039
SGTC_1611 st001856 99.4 µM 0.519773870781499 0.308358762177393 no 1071 0.30161059651923 1403 647478
SGTC_1443 4112-3303 14 µM 0.518222901961094 0.308870656397798 no 1072 0.30215137881718 1444 704433
SGTC_79 0052-0007 94.094 µM 0.514789209766474 0.31000526037645 no 1073 0.303350163138262 1532 2801472
SGTC_1180 1193-0155 285 µM 0.513752631177825 0.310348136288363 no 1074 0.303712474839408 1434 2921347
SGTC_2229 7354935 190 µM 0.513022947237902 0.3105895975538 no 1075 0.303967634487647 1481 318112
SGTC_650 1328-0195 38 µM 0.511674902150548 0.311035896663336 no 1076 0.304439277061126 1462 2780821
SGTC_3002 9075603 71.4286 µM 0.510207043689747 0.31152217876397 no 1077 0.304953209003949 1447 20105405
SGTC_1046 2001-0062 216 µM 0.509260916407315 0.311835792636765 no 1078 0.305284674653174 1453 739778
SGTC_2882 9058044 58.44 µM 0.506105214848613 0.312882802401663 no 1079 0.306391394941736 1391 18076804
SGTC_2729 fluphenazine 10.66 µM 0.505961879188721 0.31293039475071 no 1080 0.306441705534291 1410 3372 An atypical antipsychotic.
SGTC_1158 4092-0494 91.8 µM 0.504836279466003 0.313304240738264 no 1081 0.306836916049272 1561 1148199
SGTC_1402 3909-7673 35.9 µM 0.504555755347688 0.313397441243398 no 1082 0.306935446154067 1435 5328014
SGTC_868 0527-0199 213 µM 0.504100156470446 0.313548833461981 no 1083 0.307095498493631 1495 2849450
SGTC_2439 5492030 7.2 µM 0.502964571942121 0.313926316685711 no 1084 0.307494590429501 1491 5722370
SGTC_1184 1269-1718 139 µM 0.502846284357459 0.313965648243416 no 1085 0.307536174756818 1592 5403821
SGTC_3060 1327-0027 12.5 µM 0.498755611629034 0.31532712714292 no 1086 0.308975780933086 1483 16000455 YPR107C YTH1
SGTC_967 1306-0166 352 µM 0.498639623464378 0.315365767625829 no 1087 0.309016642909825 1562 4437607
SGTC_1899 st063254 59.6 µM 0.498606221480972 0.31537689559061 no 1088 0.309028410678653 1406 3093813
SGTC_2443 5493264 126.67 µM 0.498532556726502 0.315401437802823 no 1089 0.309054364015888 1583 5340055
SGTC_2960 9079389 5.97 µM 0.497292063884022 0.315814843718948 no 1090 0.309491553681102 1590 16457355
SGTC_1400 3771-8998 51.5 µM 0.494576117268065 0.316720762782931 no 1091 0.310449682041645 1524 670767
SGTC_1420 4'-methoxyflavone 42 µM 0.493191779498724 0.31718294004213 no 1092 0.31093854289161 1532 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13
SGTC_2655 perillic acid 100 µM 0.490569511805741 0.318059196209323 no 1093 0.311865477219069 1459 5702197 An apoptosis inducer.
SGTC_417 st075190 100 µM 0.490222278935976 0.318175303976341 no 1094 0.311988308663511 1586 222757
SGTC_1155 4088-0394 48.2 µM 0.489734102794924 0.318338570589566 no 1095 0.312161033265661 1454 2326248
SGTC_2102 5377816 72.7585 µM 0.487828590197135 0.318976191563633 no 1096 0.312835629324827 1587 1379702
SGTC_1819 st053448 58.6 µM 0.486628721958306 0.319377965625225 no 1097 0.313260732782096 1526 2857616
SGTC_185 k048-0037 25.491 µM 0.486529663116142 0.319411144815758 no 1098 0.313295839617419 1539 6827589
SGTC_3000 9075062 71.4286 µM 0.48623556544242 0.319509659661826 no 1099 0.31340007893394 1481 17057871
SGTC_98 0074-0023 107.663 µM 0.484726760120223 0.32001526925476 no 1100 0.313935090761318 1452 3563821
SGTC_2325 6158266 200 µM 0.484676590375284 0.320032087184165 no 1101 0.313952887331712 1488 3623240
SGTC_85 0868-0259 160.055 µM 0.483839709759699 0.320312681279454 no 1102 0.314249815393455 1529 83173
SGTC_2611 pyromycin 23.93 µM 0.483289835232556 0.320497102296979 no 1103 0.314444978203258 1473 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release.
SGTC_1099 5-nonyloxytryptamine 2.85 µM 0.481640745607434 0.32105045194874 no 1104 0.315030587989454 1468 23581825 A 5-HT1D beta serotonin receptor agonist.
SGTC_266 formosanin C 406 nM 0.480910663716616 0.321295556942499 no 1105 0.315289996739929 1515 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1
SGTC_213 1246-0773 967 nM 0.480409676595387 0.321463794691976 no 1106 0.315468057484515 1524 6251622
SGTC_1061 3448-9325 110 µM 0.480240849072015 0.321520497342323 no 1107 0.315528071787017 1492 723482
SGTC_100 0086-0128 49.5915 µM 0.478338576974767 0.322159684299186 no 1108 0.316204621768617 1409 93297
SGTC_59 0330-0160 1.33 µM 0.477309863872481 0.322505564034133 no 1109 0.316570744029868 1504 4293482
SGTC_3135 9127742 49.47 µM 0.474288669633806 0.323522254577254 no 1110 0.317647035058575 1500 3643468
SGTC_1613 st002381 52.1 µM 0.473224232822579 0.323880772832213 no 1111 0.318026605412376 1497 551167
SGTC_896 0964-0007 44.5 µM 0.472945312702801 0.32397474434537 no 1112 0.318126097915412 1520 6756758
SGTC_1310 1188-0297 994 nM 0.472304534180697 0.324190672752655 no 1113 0.318354717214844 1500 1588352
SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM 0.470735660457894 0.324719598609195 no 1114 0.318914757687013 1505 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_1784 st039334 36.3 µM 0.470480219719687 0.324805750715352 no 1115 0.319005981501466 1611 3496984
SGTC_2263 7948595 193.29 µM 0.470202762911326 0.324899338766019 no 1116 0.319105080187335 1510 2971371
SGTC_2768 sulfasalazine 50.2 µM 0.469382553424177 0.325176065560167 no 1117 0.319398108329832 1658 5384001 An antioxidant and salicylic acid derivative.
SGTC_1001 4048-4355 44.4 µM 0.468679574005002 0.325413317393218 no 1118 0.319649344646543 1488 21824233
SGTC_47 0149-0135 24.25 µM 0.467883982853145 0.325681910561124 no 1119 0.319933779135503 1413 5239155
SGTC_3045 9092950 49.47 µM 0.467648157449649 0.325761543089164 no 1120 0.32001811022832 1643 44120432
SGTC_37 0566-0070 1.56 µM 0.466895378213473 0.326015791589923 no 1121 0.320287366067221 1622 1626686
SGTC_1067 clotrimazole 1.36 µM 0.465515040020761 0.326482206027676 no 1122 0.320781334479045 1526 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_356 1634-0012 32.5 µM 0.465450058261076 0.326504169972506 no 1123 0.320804596710439 1589 735457
SGTC_2914 7968218 45.32 µM 0.465403309031809 0.326519971663196 no 1124 0.320821332478634 1592 2977111
SGTC_1747 st037496 66.6 µM 0.463550762266037 0.327146400676662 no 1125 0.321484818972623 1518 723305
SGTC_282 k297-0036 65.7 µM 0.462527698675851 0.327492553250704 no 1126 0.32185147189778 1558 5061378
SGTC_2080 5212524 12.4 µM 0.461811028058364 0.32773512644284 no 1127 0.322108420875512 1624 260183
SGTC_3230 9131665 49.47 µM 0.461438932549894 0.327861099170384 no 1128 0.322241862380316 1530 15943720
SGTC_1996 st072960 66.8 µM 0.461131026764482 0.327965355315831 no 1129 0.322352301386919 1553 1719405
SGTC_2543 pimpinellin 60.67 µM 0.457802721874354 0.3290931654992 no 1130 0.323547090064324 1491 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo.
SGTC_2640 pentamidine 10.38 µM 0.455481397333896 0.329880678761349 no 1131 0.324381473897531 1624 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_42 0133-0086 60.653 µM 0.454966939007339 0.330055311890793 no 1132 0.324566511949539 1446 162923 Model of phenazepam hydroxylation.
SGTC_935 2996-0153 430 µM 0.454740527720107 0.330132179051363 no 1133 0.324647960269327 1646 23738523
SGTC_2853 9015042 58.44 µM 0.454263570800977 0.330294130499796 no 1134 0.324819566341731 1459 6457456
SGTC_2101 5377231 179.231 µM 0.454208381733457 0.330312872084691 no 1135 0.324839425418829 1634 2844213
SGTC_292 k038-0015 474 µM 0.454007600768695 0.330381058626936 no 1136 0.324911678069798 1570 46368540
SGTC_2005 4024620 188 µM 0.453558466181787 0.330533608087936 no 1137 0.325073326619184 1524 236743
SGTC_2184 6075246 200 µM 0.453266672577 0.330632731461764 no 1138 0.325178364043043 1581 2267320
SGTC_290 2043-6722 48.1 µM 0.453001408126061 0.330722853092545 no 1139 0.325273863779862 1566 773758 YLR208W SEC13
SGTC_612 0302-0167 22.4 µM 0.452651017791608 0.330841910653389 no 1140 0.325400027880742 1636 235821
SGTC_2097 5376186 200 µM 0.452093733333454 0.331031303088982 no 1141 0.325600729009492 1618 742755
SGTC_2100 5377183 190 µM 0.451926535879169 0.331088133373135 no 1142 0.325660953576562 1653 2844202
SGTC_5 0352-0601 109.883 µM 0.451378154687016 0.331274555019386 no 1143 0.325858512559505 1552 762456
SGTC_2483 5729050 27.16 µM 0.448817856779212 0.332145478586172 no 1144 0.326781528073467 1687 2865180
SGTC_2994 9053520 71.4286 µM 0.447235001484372 0.332684364705529 no 1145 0.327352695958911 1665 4647384
SGTC_2059 5238311 157 µM 0.446179891164873 0.333043771244647 no 1146 0.327733653629086 1534 703021
SGTC_3137 9097352 49.47 µM 0.444693216598173 0.333550443595714 no 1147 0.328270736068649 1640 44120435
SGTC_1481 3346-2004 36 µM 0.443812991778658 0.333850575535549 no 1148 0.328588897335329 1558 2770522
SGTC_25 0118-0223 35.662 µM 0.443243200687208 0.334044914996586 no 1149 0.328794917212916 1612 5333628
SGTC_2329 6138490 200 µM 0.443219574428742 0.334052974199667 no 1150 0.328803460904427 1584 720019
SGTC_985 1493-0307 8.71 µM 0.441300318940171 0.334707910815448 no 1151 0.329497797628874 1667 3278274
SGTC_3196 9111891 49.47 µM 0.440676237289141 0.334920984158038 no 1152 0.329723700997147 1534 18891510
SGTC_813 k007-0158 173 µM 0.440604117298158 0.334945610721481 no 1153 0.329749810800652 1673 6523916
SGTC_640 3381-0960 37.1 µM 0.440470809343852 0.334991132795043 no 1154 0.329798074838992 1646 1745025
SGTC_2717 st081029 62.2815 µM 0.440308695883007 0.335046494655397 no 1155 0.329856771706705 1609 5292846
SGTC_120 rhodamine 6G 52.259 µM 0.439464857415434 0.335334723941774 no 1156 0.330162370265678 1545 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase
SGTC_2612 dictamnine 15.46 µM 0.439311656348123 0.335387063122096 no 1157 0.330217864640992 1561 68085 A quinoline derivative and established mutagen. YOR116C RPO31
SGTC_1956 st077085 54 µM 0.438985220699581 0.335498596331946 no 1158 0.330336122634346 1548 24208685
SGTC_797 k781-0471 270 µM 0.438118630593694 0.335794754325729 no 1159 0.330650144819841 1620 23738129
SGTC_217 ketoconazole 989 nM 0.437527056949689 0.335996983779543 no 1160 0.330864579080274 1519 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4
SGTC_1813 st051246 8.6015 µM 0.436551837778102 0.336330466102302 no 1161 0.331218198741619 1662 5291959
SGTC_575 k072-0246 11.9 µM 0.436075329760705 0.336493457877031 no 1162 0.331391037864446 1598 6796779
SGTC_3299 9121982 43.1275 µM 0.434185278528242 0.337140261066467 no 1163 0.332076951257216 1551 17594604 YPL160W CDC60
SGTC_2736 butenafine 14.65 µM 0.430730183611798 0.338323889273246 no 1164 0.333332284597213 1660 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_894 0960-0238 55.9 µM 0.430531467865897 0.338392013014199 no 1165 0.333404540599663 1602 6741907 YDL195W SEC31
SGTC_1237 0330-0133 46.1 µM 0.429784683098735 0.338648073079226 no 1166 0.333676137905731 1564 X1237 YHR072W ERG7
SGTC_374 0880-0231 82.3 µM 0.429058588895133 0.338897110227595 no 1167 0.333940293880335 1597 6833587
SGTC_2223 6903751 107.57 µM 0.427960794461557 0.339273767528943 no 1168 0.33433983214158 1631 5598863
SGTC_1512 0259-0544 12.2 µM 0.427254269945252 0.339516263682937 no 1169 0.33459706847602 1649 18476
SGTC_559 1550-0661 158 µM 0.426565970253018 0.339752568553293 no 1170 0.334847744074679 1649 5830875
SGTC_2514 salinomycin 42.74 µM 0.426315254066021 0.33983865929722 no 1171 0.334939072057804 1741 23682228 A polyether potassium ionophore.
SGTC_1087 pterostilbene 9.05 µM 0.424784579463427 0.340364442297099 no 1172 0.335496859998168 1696 5281727 Similar to reservatol, lowers cholesterol.
SGTC_1256 0570-0116 285 µM 0.424108756408266 0.340596684734815 no 1173 0.335743249901306 1544 410638
SGTC_1734 st037168 69.4 µM 0.420386367994724 0.341876941982553 no 1174 0.337101612495336 1584 708907
SGTC_2193 5925765 200 µM 0.416709610238958 0.343143292931397 no 1175 0.338445412079163 1648 877370
SGTC_3319 9138450 16.7555 µM 0.416476215774422 0.34322373845748 no 1176 0.338530783947869 1589 2029690
SGTC_1480 1070-0044 41.2 µM 0.415237901286734 0.343650674809189 no 1177 0.33898387781544 1660 3124987
SGTC_2152 5568786 200 µM 0.412519048479 0.344588758820968 no 1178 0.339979510923206 1603 5399883
SGTC_3274 9138298 49.47 µM 0.411977566084279 0.344775700544765 no 1179 0.340177933240935 1584 17015756
SGTC_2574 2',4'-dihydroxychalcone 14.64 µM 0.41135461481465 0.34499081552277 no 1180 0.340406263997677 1751 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_816 0325-0417 81.3 µM 0.411043739044464 0.345098184615832 no 1181 0.340520231399832 1582 68101
SGTC_2704 st078022 71.1 µM 0.409874836251114 0.345502007368582 no 1182 0.340948882718044 1743 54697681
SGTC_1483 3453-0561 55.9 µM 0.402946461613246 0.347899161909988 no 1183 0.343493805312971 1660 4546991
SGTC_2798 7813637 45.45 µM 0.402717555892638 0.347978465685833 no 1184 0.343578008676699 1673 956368
SGTC_1540 guanosine 70.6 µM 0.399357381437603 0.349143352798772 no 1185 0.344814946020192 1696 6802 Guanosine is a purine nucleoside
SGTC_761 k216-0224 480 µM 0.398851798172558 0.349318749084666 no 1186 0.34500120386276 1801 1340404
SGTC_2753 fluvastatin 17.09 µM 0.398196610042374 0.349546093969307 no 1187 0.345242632298581 1638 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5
SGTC_33 0986-0033 35.816 µM 0.39807731178886 0.349587495291736 no 1188 0.345286598959311 1637 2848082
SGTC_252 miconazole 1.30953 nM 0.397899729988525 0.349649126677499 no 1189 0.345352049541273 1646 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_2323 6148992 148.28 µM 0.397825198377514 0.349674994734568 no 1190 0.345379520723622 1583 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42
SGTC_1111 tnp00062 510.699 nM 0.396804797458646 0.350029220502588 no 1191 0.345755706351692 1748 676306
SGTC_2409 alverine citrate 63.97 µM 0.396058469777027 0.350288386144429 no 1192 0.346030947380567 1760 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_1322 1348-1070 12 µM 0.395189362140822 0.350590275549771 no 1193 0.346351571438773 1632 6758089
SGTC_479 n-linoleoylglycine 10 µM 0.393938538468474 0.351024921790179 no 1194 0.346813208318528 1632 6433346 An anti-infammatory.
SGTC_598 3937-0236 20.2 µM 0.392840017203818 0.351406805614014 no 1195 0.347218823187934 1691 1379313
SGTC_1917 st066507 28.5 µM 0.391832896603715 0.351757047275535 no 1196 0.347590843379294 1618 3156428
SGTC_746 1095-0025 46.6 µM 0.391671993599402 0.351813015434374 no 1197 0.347650292938139 1731 6749286
SGTC_2879 9041815 71.43 µM 0.389571994508261 0.352543768721376 no 1198 0.348426532146505 1621 4942971
SGTC_11 0438-0307 1.3 µM 0.388366920014515 0.352963354103737 no 1199 0.348872260396178 1741 4011476
SGTC_870 0573-2213 57.6 µM 0.38818331933387 0.353027296290578 no 1200 0.348940188229484 1590 3916321
SGTC_1722 st034304 3.6505 µM 0.385860056664026 0.353836771649712 no 1201 0.349800157091828 1603 4036148 YLR033W RSC58
SGTC_50 0929-0078 56.389 µM 0.383681026044945 0.354596594469847 no 1202 0.350607438648333 1699 1377751
SGTC_639 0833-0042 114 µM 0.382446921814011 0.355027180693238 no 1203 0.351064946055629 1613 5978911 YPR085C | YHR062C ASA1 | RPP1
SGTC_2273 7815444 169.05 µM 0.38230846431221 0.35507550089522 no 1204 0.351116288539155 1776 2824616
SGTC_1392 3455-1037 33.9 µM 0.382106096508574 0.355146129308452 no 1205 0.351191334978603 1722 981132
SGTC_2039 Aminomethylbenzodioxan 200 µM 0.377851454588975 0.356632191309031 no 1206 0.352770473549068 1652 15053
SGTC_1590 st077108 57.8 µM 0.37764761541832 0.356703443160232 no 1207 0.352846193782827 1790 5489485
SGTC_1464 k208-0027 110 µM 0.376726349307317 0.357025533475513 no 1208 0.35318848961112 1755 X1464
SGTC_2937 9044753 11.33 µM 0.376188980567208 0.357213453817317 no 1209 0.353388203501744 1618 6465530 YGL099W LSG1
SGTC_1417 3966-0327 90.4 µM 0.374711073866694 0.357730463164993 no 1210 0.353937677800757 1675 651118
SGTC_1504 k297-0033 30 µM 0.374400942903355 0.357838988042358 no 1211 0.354053020770121 1603 4388117
SGTC_2947 9072639 7.68 µM 0.37186608428027 0.358726447362612 no 1212 0.354996278988221 1607 16488146
SGTC_2781 5567276 71.43 µM 0.371556511289 0.358834881910827 no 1213 0.355111536714544 1731 2853274
SGTC_774 k060-0086 136 µM 0.370897297966441 0.359065823348591 no 1214 0.355357013880466 1849 5911235
SGTC_3280 9140961 49.47 µM 0.370684149941639 0.359140506273622 no 1215 0.355436398565119 1661 4901226
SGTC_1604 st002052 72.4 µM 0.370453067573981 0.359221479125385 no 1216 0.355522469788718 1689 6254834 YHR062C RPP1
SGTC_2583 asiatic acid 100 µM 0.369913928054906 0.359410421905897 no 1217 0.355723311668503 1693 5320556 A kinase inhibitor; arrests cells at G2/M.
SGTC_723 4182-0001 115 µM 0.369868994480572 0.359426170541082 no 1218 0.355740052268282 1641 744821 YLR208W SEC13
SGTC_1336 1486-0901 104 µM 0.369299362165403 0.359625839975197 no 1219 0.355952300461846 1707 5006114
SGTC_994 3910-0338 138 µM 0.369239525106543 0.359646816487572 no 1220 0.355974598678131 1752 3479481
SGTC_1130 3454-2858 15.9 µM 0.367678012766942 0.360194370447222 no 1221 0.356556668567811 1620 715628 YIL048W NEO1
SGTC_2359 9039622 200 µM 0.367202902442866 0.360361027803819 no 1222 0.35673383724407 1743 6463596
SGTC_814 3342-0569 96 µM 0.366970093422641 0.360442701337779 no 1223 0.356820663032402 1693 4346283
SGTC_3337 9144342 33.5465 µM 0.36634746913862 0.3606611602606 no 1224 0.357052906298557 1742 17682949
SGTC_3176 9106582 49.47 µM 0.364163642922294 0.361427754046627 no 1225 0.357867907222088 1712 17018027
SGTC_1284 0929-0043 16 µM 0.363571188654257 0.361635820820406 no 1226 0.358089122291101 1661 1239883
SGTC_2657 nystatin 74.44 µM 0.360481564401151 0.36272154217287 no 1227 0.359243520359369 1732 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_2685 mycophenolic acid 18.85 µM 0.360377922002 0.362757982227995 no 1228 0.359282267353068 1750 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_1826 st055655 41.6 µM 0.360106528087273 0.362853408612771 no 1229 0.359383735564253 1685 676168
SGTC_474 dl-dihydrosphingosine 5 µM 0.359929663053679 0.362915601735023 no 1230 0.359449866845141 1743 3058739 A sphingolipid protein kinase C inhibitor.
SGTC_680 0417-1641 114 µM 0.35752366462154 0.363762009667582 no 1231 0.360349906741695 1672 2835990
SGTC_1985 st071382 65.5 µM 0.355929491346572 0.364323191753657 no 1232 0.360946684635265 1704 6123237
SGTC_1438 4092-1045 4 µM 0.353293927174522 0.365251602763575 no 1233 0.361934048892888 1676 1351342
SGTC_3216 9129716 49.47 µM 0.352045909780707 0.365691508823646 no 1234 0.362401916263887 1625 8056934
SGTC_1828 st055811 49 µM 0.351986338054917 0.3657125113216 no 1235 0.36242425416535 1825 5877589
SGTC_1096 rimcazole 32.2 µM 0.351969501907677 0.365718447115632 no 1236 0.362430567382747 1698 18528119 A dopamine reuptake inhibitor.
SGTC_154 3389-1638 511.116 µM 0.351409674005997 0.365915839736604 no 1237 0.362640512907322 1579 5238686
SGTC_2132 5317594 122.667 µM 0.351259203833942 0.365968900849513 no 1238 0.362696948971741 1747 794577
SGTC_1990 st072050 59.8 µM 0.350042818301031 0.366397935527038 no 1239 0.363153281790647 1663 17233948
SGTC_1783 st039459 87.517 µM 0.349887085022812 0.366452876711369 no 1240 0.363211719916755 1833 729761
SGTC_460 trequinsin 123 µM 0.348088812166128 0.367087487881444 no 1241 0.363886743084937 1714 5537 A vasodilator.
SGTC_2436 5633522 8.09 µM 0.348022606465285 0.367110858843006 no 1242 0.363911602999589 1837 5724242
SGTC_2098 5376439 882.5 nM 0.347817167179516 0.367183383128776 no 1243 0.363988748085793 1822 2844116
SGTC_2150 5556613 200 µM 0.347205493634771 0.367399344500226 no 1244 0.36421847197528 1732 743190
SGTC_3269 9137823 49.47 µM 0.346789933417534 0.367546088781323 no 1245 0.364374570173477 1671 17682936
SGTC_1939 st074455 53.6 µM 0.346327163728139 0.367709526621815 no 1246 0.364548428290011 1838 1644229
SGTC_3139 9095020 49.47 µM 0.344352165371846 0.368407312053036 no 1247 0.365290728997165 1643 25236292
SGTC_907 3448-6986 75.5 µM 0.338359641178747 0.37052717607898 no 1248 0.367546092014013 1821 590582
SGTC_1063 disulfiram 1.84 µM 0.337064920862437 0.370985704701249 no 1249 0.368033980365327 1728 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM 0.336936723501895 0.371031116115984 no 1250 0.368082300466372 1852 756377
SGTC_2237 6667747 47.222 µM 0.336116402682365 0.371321741259328 no 1251 0.368391544860926 1680 729940 YDL015C TSC13
SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM 0.33605987451322 0.371341770893429 no 1252 0.368412857982749 1739 368090
SGTC_480 am 92016 50 µM 0.336041523318031 0.371348273349914 no 1253 0.368419777120338 1696 2129 K+ channel blocker.
SGTC_429 1112-0049 25.5 µM 0.334249335682809 0.371983483398107 no 1254 0.369095709076051 1658 2836170
SGTC_1183 1254-0324 198 µM 0.332986919240173 0.372431134534886 no 1255 0.36957207859587 1806 5799357
SGTC_1662 st014054 52 µM 0.332949228579607 0.372444502244817 no 1256 0.36958630414996 1744 2838777
SGTC_1062 mesoridazine 14.2 µM 0.332240723897175 0.372695815490479 no 1257 0.369853747670835 1728 4078 A neuroleptic.
SGTC_1872 amphotericin b 148 nM 0.331915030638041 0.372811360130716 no 1258 0.369976710194107 1818 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1
SGTC_1224 0823-0416 294 µM 0.331406028051045 0.372991959459789 no 1259 0.370168906101508 1800 3598164
SGTC_3180 9109287 49.47 µM 0.330506885853324 0.373311052503652 no 1260 0.370508495264821 1740 18891271
SGTC_2037 5169046 200 µM 0.328722493028721 0.373944565836925 no 1261 0.37118272567601 1771 5718022
SGTC_3239 9133757 49.47 µM 0.327943409696179 0.374221270882298 no 1262 0.371477225437923 1796 17036923
SGTC_2199 6590217 200 µM 0.32703634109209 0.374543513777765 no 1263 0.371820199461973 1804 703109
SGTC_2701 st077767 14.721 µM 0.325565247834646 0.375066316887582 no 1264 0.372376654513713 1736 5721188
SGTC_2043 5101342 149 µM 0.323262798580798 0.375885031304449 no 1265 0.373248112598419 1771 678451
SGTC_1629 st005085 44.9 µM 0.322123990879312 0.376290180118264 no 1266 0.373679382028708 1663 24207091
SGTC_3157 9099274 49.47 µM 0.321977895067999 0.376342165886477 no 1267 0.373734720353871 1883 17217662
SGTC_2861 9024595 19.48 µM 0.321817098656361 0.376399385212403 no 1268 0.373795629997095 1797 16482810
SGTC_1213 1315-0166 115 µM 0.320857522895726 0.37674090621867 no 1269 0.374159182553016 1630 768401
SGTC_2213 7173844 200 µM 0.320540650419332 0.376853704976356 no 1270 0.37427925999941 1751 892728
SGTC_2945 9067681 61.76 µM 0.320124219843333 0.377001959937333 no 1271 0.374437083099997 1776 16456930
SGTC_1297 1068-0111 14.1 µM 0.32005456570344 0.377026759531495 no 1272 0.374463483389969 1693 767057
SGTC_2366 9070441 60.58 µM 0.318724906515301 0.377500267295479 no 1273 0.374967563113785 1687 6837235
SGTC_2071 5230951 39.92 µM 0.317972463128364 0.377768303165833 no 1274 0.375252912476467 1832 1799272
SGTC_617 3770-0098 35 µM 0.317942356197728 0.37777902910176 no 1275 0.375264331359695 1768 5962639
SGTC_1582 3',3',6'-trihydroxyflavone 74 µM 0.317495487531369 0.377938242214223 no 1276 0.375433831464107 1719 688803
SGTC_1943 st076331 65.2 µM 0.317196902732861 0.378044635397403 no 1277 0.37554709996726 1896 24208415
SGTC_2373 9071805 200 µM 0.316683696028077 0.378227525307319 no 1278 0.375741810610861 1915 10149009
SGTC_1903 st060211 78.3 µM 0.316598760982891 0.378257795983453 no 1279 0.375774038023766 1864 688960
SGTC_315 k915-0449 187 µM 0.314294660098655 0.379079257335479 no 1280 0.37664862676113 1807 20970215 YNL149C PGA2
SGTC_2384 9036245 200 µM 0.314073796270366 0.379158028780164 no 1281 0.376732495416652 1839 6462766
SGTC_2327 6189656 200 µM 0.310700165485552 0.380361861610716 no 1282 0.378014285719192 1858 5349088
SGTC_2360 9040895 200 µM 0.309948872609793 0.380630108232189 no 1283 0.378299918313236 1725 4914414
SGTC_888 0916-0002 6.97 µM 0.308203002982963 0.381253686650139 no 1284 0.3789639337838 1840 2802138 YIL048W NEO1
SGTC_1172 0370-0043 85 µM 0.305876527435018 0.382085121259498 no 1285 0.379849329174884 1802 376585
SGTC_2547 epiafzelechin trimethyl ether 100 µM 0.30487824047433 0.3824420555785 no 1286 0.380229444436424 1819 6708630 An antioxidant.
SGTC_799 1310-0557 151 µM 0.304771252169738 0.382480314837887 no 1287 0.380270188979928 1803 5354492
SGTC_1153 4055-0057 267 µM 0.303938171511195 0.382778265578986 no 1288 0.380587497963808 1740 882706
SGTC_1353 1498-1206 8.11 µM 0.303244197884351 0.383026517765999 no 1289 0.380851884346239 1764 6756808
SGTC_2821 7996764 71.43 µM 0.301039177279779 0.383815628713909 no 1290 0.381692310101832 1803 2987135
SGTC_2182 6325192 200 µM 0.300212654145165 0.384111541012236 no 1291 0.382007476698786 1860 736248
SGTC_492 tmb-8 126 µM 0.29744603843105 0.385102537100198 no 1292 0.383062999823275 1898 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1
SGTC_1794 st048918 76.9 µM 0.297073670614668 0.385235975965596 no 1293 0.383205132628766 1902 672303
SGTC_2228 7354201 200 µM 0.295254781271113 0.385887974190634 no 1294 0.383899628390578 1871 753451
SGTC_2906 7926292 26.41 µM 0.295192269783874 0.385910387771573 no 1295 0.383923503425219 1771 2966319
SGTC_428 3448-4153 16.5 µM 0.29453689438211 0.386145396450597 no 1296 0.384173837692397 1688 3834874
SGTC_494 Boc-Gly-Val-Val-CHO 140 µM 0.292770468013337 0.386779020692359 no 1297 0.384848801377582 1793 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA.
SGTC_2764 methyldopa 94.69 µM 0.290777469749937 0.387494279612266 no 1298 0.385610758847054 1913 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent.
SGTC_2915 7971052 15.16 µM 0.285788690128931 0.389286352253641 no 1299 0.387519985495214 1879 5741558
SGTC_2919 7978188 46.38 µM 0.283201264175362 0.3902167399549 no 1300 0.388511279667933 1933 2980291
SGTC_727 3032-0951 202 µM 0.281600854499029 0.39079253121809 no 1301 0.389124792458583 1829 3652836
SGTC_1307 1187-1599 12.2 µM 0.2809275620702 0.39103483828358 no 1302 0.389382980050867 1790 1538471
SGTC_3224 9130643 49.47 µM 0.28040985903786 0.391221180015133 no 1303 0.389581536964024 1863 17644395
SGTC_3278 9139605 49.47 µM 0.280184242024197 0.391302396288414 no 1304 0.389668077867829 1899 7958859
SGTC_1942 st076330 65.2 µM 0.278367705035222 0.391956474900338 no 1305 0.390365053897572 1869 24208414
SGTC_65 0798-0905 34.986 µM 0.278233194261912 0.392004920225826 no 1306 0.39041667756254 1968 3602145
SGTC_3264 9137442 49.47 µM 0.276435132477234 0.392652669655529 no 1307 0.391106937881851 1914 17015726
SGTC_2846 9008642 19.48 µM 0.276025660933966 0.392800222894987 no 1308 0.391264178503457 1780 2992898
SGTC_3322 9139058 2.11 µM 0.274569394987674 0.393325113623066 no 1309 0.391823541084993 1879 4908926 YPR165W RHO1
SGTC_228 caffeine 993.056 µM 0.273060213684629 0.3938692816069 no 1310 0.39240346487875 1918 2519 Caffeine is a phosphodiesterase inhibitor.
SGTC_2444 5485484 36.41 µM 0.271808247851827 0.394320862349916 no 1311 0.39288473151916 1897 6790631
SGTC_597 k018-0003 82.8 µM 0.270995295604086 0.394614168184823 no 1312 0.393197325246718 1920 6786234
SGTC_2833 9001315 45.46 µM 0.269895560408808 0.395011037778202 no 1313 0.393620301379413 1805 2989378
SGTC_3160 9100216 49.47 µM 0.268019119384794 0.395688454303255 no 1314 0.394342300914321 1942 17191039
SGTC_969 1313-0238 134 µM 0.263691330191491 0.397252034154817 no 1315 0.396008888333236 1819 5212874
SGTC_1209 2323-2347 50.3 µM 0.262742112156753 0.397595197451985 no 1316 0.396374677980899 1993 5412760
SGTC_2418 pentamidine 31.67 µM 0.261225188723902 0.398143763245925 no 1317 0.396959427256288 1957 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_2973 9094665 17.96 µM 0.261121639069069 0.398181217315394 no 1318 0.396999352425998 1948 25237061 YIL048W NEO1
SGTC_2181 6316240 54.2555 µM 0.260633207788809 0.398357896304548 no 1319 0.39718768920334 1783 12779990
SGTC_389 tpck 16.7 µM 0.258793366449815 0.399023604174342 no 1320 0.397897338186303 1842 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.
SGTC_3109 9122853 49.47 µM 0.258779673517265 0.399028559777659 no 1321 0.39790262098526 1910 1234709
SGTC_151 3013-0144 2.285 µM 0.258318045070505 0.399195637047772 no 1322 0.398080730398382 1953 906558 YHR107C CDC12
SGTC_1957 st077035 62.4 µM 0.257999538714442 0.399310924881321 no 1323 0.398203631614658 1920 705593
SGTC_3130 9127414 49.47 µM 0.257577729122114 0.39946361828174 no 1324 0.3983664097237 1915 1494646
SGTC_3330 9141424 71.43 µM 0.257030834848615 0.399661614735043 no 1325 0.398577484868772 1949 27261020
SGTC_89 0302-0250 142.109 µM 0.256631715230343 0.399806127453775 no 1326 0.39873154476692 1913 4203518 YLR208W SEC13
SGTC_2886 9058944 51.95 µM 0.254957080460013 0.400412626447905 no 1327 0.399378124385267 1858 4949929
SGTC_2863 9028737 58.44 µM 0.254507123781232 0.40057562732611 no 1328 0.399551900634149 1995 6460917
SGTC_3068 9116768 49.47 µM 0.252576918509453 0.401275057776981 no 1329 0.400297584082345 1851 41904888
SGTC_2898 9056270 58.44 µM 0.250529390162911 0.40201734738997 no 1330 0.40108898957435 1888 19154699
SGTC_44 0929-0055 61.211 µM 0.25030772849974 0.402097727558751 no 1331 0.401174690096387 1827 1379590
SGTC_1472 k841-0093 193 µM 0.248590025926968 0.402720750411545 no 1332 0.401838962255564 1964 X1472
SGTC_926 2268-1401 59.4 µM 0.242993202456711 0.404752464344273 no 1333 0.404005331660297 1984 2931578
SGTC_2892 9047358 58.44 µM 0.242467981339406 0.404943258675973 no 1334 0.404208781957568 1858 6466771
SGTC_595 3909-8003 73.7 µM 0.242428130797204 0.404957735897199 no 1335 0.404224219570781 1911 699517
SGTC_2614 arthonioic acid 13.39 µM 0.241523970945913 0.405286241183059 no 1336 0.40457452008619 1885 6710684
SGTC_438 sphingosine 6.67 µM 0.241122342563738 0.405432184860836 no 1337 0.404730148354175 1706 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes.
SGTC_902 1120-0002 2.07 µM 0.239822599406328 0.405904575419621 no 1338 0.405233893183345 1838 3280475
SGTC_1192 1488-0095 21.4 µM 0.239301572674224 0.406093980665658 no 1339 0.405435873006948 1897 915875
SGTC_3095 9117207 49.47 µM 0.23863574935221 0.406336054801397 no 1340 0.405694020936765 2007 17015229
SGTC_2841 9004761 38.96 µM 0.235136458755231 0.407608882347145 no 1341 0.40705141093026 1760 2991039
SGTC_1211 1056-0033 32.3 µM 0.234079927167338 0.40799337624653 no 1342 0.407461464437224 2013 6741922
SGTC_486 niguldipine 82 µM 0.23291946713475 0.408415793990312 no 1343 0.407911970774772 1935 1236 A calcium channel blocker.
SGTC_2133 5320837 200 µM 0.232236281343488 0.408664529485924 no 1344 0.408177249763417 1960 2841355
SGTC_2679 rapamycin 1 nM 0.232105188897432 0.408712262066971 no 1345 0.408228157383047 1910 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2
SGTC_2635 hydroquinidine 100 µM 0.231982523617143 0.408756927426216 no 1346 0.408275793852746 1876 442912 An experimental heart treatment.
SGTC_697 0508-1955 564 µM 0.231272977081999 0.409015313507336 no 1347 0.408551369403573 2024 6243113
SGTC_3293 9120939 62.045 µM 0.231087733693543 0.409082777630732 no 1348 0.40862332216848 1943 934087
SGTC_20 0481-0013 4.944 µM 0.230946246014964 0.409134308097564 no 1349 0.408678281290743 1845 182045
SGTC_3300 9124615 50.48 µM 0.230092261312622 0.409445366587778 no 1350 0.409010039081099 1964 24824903
SGTC_2845 9003024 42.97 µM 0.22977159580476 0.409562181692245 no 1351 0.409134628747049 1977 2990173
SGTC_2971 9092186 9.93 µM 0.229738939207809 0.409574078601028 no 1352 0.409147317482292 1742 25236400
SGTC_2298 7976326 193.81 µM 0.228909772136389 0.40987617483922 no 1353 0.409469522575467 1969 2235818
SGTC_874 0599-0792 117 µM 0.228892047102293 0.409882633309603 no 1354 0.409476410994838 2044 765305
SGTC_2433 5607874 27.82 µM 0.228172639792112 0.410144784354563 no 1355 0.409756015360184 1868 2252428
SGTC_1638 st008370 60.6 µM 0.228054701041554 0.410187764909606 no 1356 0.409801857739212 1941 24207134
SGTC_3276 9139060 49.47 µM 0.225428116060109 0.411145252967633 no 1357 0.410823120515163 1922 4870619
SGTC_2403 6032726 181.2 µM 0.224430737312714 0.411508973705836 no 1358 0.4112110778566 1888 2881040
SGTC_2662 daunorubicin 22.37 µM 0.223814120312361 0.411733877594955 no 1359 0.411450971124272 1949 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_1047 2043-3044 82 µM 0.222686452700295 0.412145256224838 no 1360 0.411889772906382 1870 669592
SGTC_455 paf C-16 10 µM 0.22239327762912 0.412252223749597 no 1361 0.412003872239338 1910 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis.
SGTC_163 TUB2.036 7.546 µM 0.222390469713999 0.412253248273859 no 1362 0.412004965073699 2030 15992207 YJR013W GPI14
SGTC_3075 9116269 49.47 µM 0.220832712258047 0.41282171938207 no 1363 0.412611345805928 1931 17015205 YNL244C SUI1
SGTC_1164 k060-0068 93.7 µM 0.21993490995007 0.413149436769329 no 1364 0.412960923843351 1983 5963676
SGTC_750 4073-0104 132 µM 0.219896030719306 0.413163629903895 no 1365 0.412976063843445 1997 22330957
SGTC_2710 st078562 53.7235 µM 0.215233678899322 0.414866471667861 no 1366 0.414792567115805 1964 17250908
SGTC_2955 9076254 12.21 µM 0.213626080765374 0.415453991310664 no 1367 0.415419329677348 2038 16459619
SGTC_2282 7944268 200 µM 0.21141897648267 0.416260916757387 no 1368 0.41628017515205 1993 2970414
SGTC_1114 scopoletin 1.73284 µM 0.211189999648684 0.416344651803562 no 1369 0.416369506950323 2045 5280460 A coumarin with genotoxic properties.
SGTC_2980 9014342 25.29 µM 0.208306011047976 0.417399627838027 no 1370 0.417495019227414 1936 2996599
SGTC_1444 4112-3581 28 µM 0.207830485282094 0.417573634640525 no 1371 0.417680664242157 1947 2877249
SGTC_493 zm226600 134 µM 0.20712280309994 0.417832623173695 no 1372 0.417956976961534 1986 5240098 A potassium channel opener. YCR052W RSC6
SGTC_2513 baicalein 25.65 µM 0.206105656489 0.418204927965699 no 1373 0.418354190196162 1863 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2
SGTC_424 splitomicin 100 mM 0.205510030887787 0.418422978047043 no 1374 0.418586830919167 1842 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_3167 9103034 49.47 µM 0.20543483994563 0.418450506167704 no 1375 0.418616201184502 2000 5127859
SGTC_24 0417-1663 219 µM 0.204431874785215 0.418817739418798 no 1376 0.41900801181521 1915 4329390
SGTC_3158 9100007 49.47 µM 0.203974419161564 0.418985259195566 no 1377 0.419186744601838 1890 19297233
SGTC_1681 tripelennamine 100 µM 0.202868189251144 0.419390420100916 no 1378 0.419619029276567 2071 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist.
SGTC_1355 1499-0035 1.68 µM 0.201373625386896 0.419937945479249 no 1379 0.420203218334981 1912 1548538
SGTC_1507 4075-3230 155 µM 0.200862088104255 0.420125380050446 no 1380 0.420403206408379 2083 659771
SGTC_2241 6772625 37.8075 µM 0.200768820480054 0.420159556594894 no 1381 0.420439672071567 2095 2285411
SGTC_6 0844-0013 19.835 µM 0.199206984508684 0.420731957591818 no 1382 0.421050418035421 2051 1584900
SGTC_2423 st077119 87.2 µM 0.197990080136315 0.421178060037465 no 1383 0.421526412503452 2040 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae).
SGTC_2996 9066192 71.4286 µM 0.196049702385004 0.421889588218471 no 1384 0.422285631939379 1884 6472854
SGTC_560 2332-1943 155 µM 0.1951633206044 0.422214705617284 no 1385 0.422632546401621 1978 21177716
SGTC_1363 1636-0063 10.4 µM 0.194814263400324 0.422342751430944 no 1386 0.422769177825635 1952 6072185
SGTC_1132 3456-3614 2.5 µM 0.194539469505977 0.422443560762842 no 1387 0.422876746907607 2101 3125502
SGTC_618 k072-0232 33.2 µM 0.193865512303666 0.42269082638204 no 1388 0.423140594268021 1973 5872756 YGL099W LSG1
SGTC_2321 7390090 138.78 µM 0.193367543714632 0.422873543777725 no 1389 0.423335566037796 1890 649046
SGTC_1635 st007035 42.4 µM 0.193273256751581 0.42290814194251 no 1390 0.423372484730799 2027 3716403
SGTC_3298 9116858 71.43 µM 0.191541934415424 0.423543548099699 no 1391 0.424050514881347 2029 2506942
SGTC_244 nsc-207895 1.295 µM 0.191322622094245 0.423624051322767 no 1392 0.424136419289441 1939 42640
SGTC_2489 cantharidin 73.42 µM 0.190379500350301 0.42397028038511 no 1393 0.424505880126 2012 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_2163 5671233 125 µM 0.189824034933154 0.424174224563225 no 1394 0.424723510581289 2050 701023
SGTC_2347 9049783 174.81 µM 0.189603853712982 0.424255071723127 no 1395 0.424809783583257 2031 6467988 YPL169C MEX67
SGTC_3028 9087778 49.47 µM 0.189451030793207 0.424311187824523 no 1396 0.424869665885366 1965 17217395
SGTC_51 1013-0126 23.419 µM 0.185971833288257 0.425589151269156 no 1397 0.426233424881158 2130 1627850
SGTC_3120 9124077 49.47 µM 0.185725814244605 0.425679547660223 no 1398 0.426329891836487 2100 18774327 YGL155W CDC43
SGTC_643 k048-0106 28.4 µM 0.185532892335327 0.425750436955815 no 1399 0.42640554186588 2023 6763920
SGTC_1296 1068-0102 11.9 µM 0.185061966281341 0.425923489150679 no 1400 0.426590216394883 2068 767053
SGTC_732 3970-1727 52.7 µM 0.183562596358174 0.42647456066267 no 1401 0.42717830411192 2103 1275699
SGTC_1761 st044296 37 µM 0.181106934749424 0.427377412872 no 1402 0.428141820733391 1996 1826700
SGTC_121 0557-0495 61.343 µM 0.180481524836188 0.427607412991453 no 1403 0.428387278639388 2029 3104427
SGTC_964 1287-0107 19.4 µM 0.178283479760574 0.428415958520296 no 1404 0.429250176105655 2079 51516812 YPR165W RHO1
SGTC_1380 2291-0730 164 µM 0.176005932284219 0.429254065873935 no 1405 0.43014464095768 1949 2999191
SGTC_2920 7982904 15.77 µM 0.175064881541902 0.429600453458825 no 1406 0.430514326276262 1981 6456808
SGTC_1737 st035557 69.7 µM 0.174099048605791 0.429956019385599 no 1407 0.430893810442442 2054 5716916
SGTC_1491 4138-0063 26.5 µM 0.173554365206399 0.430156566568989 no 1408 0.431107849455006 2110 23883227
SGTC_909 3448-9333 149 µM 0.171622489749735 0.430868009459241 no 1409 0.431867162762859 1965 3344074
SGTC_1291 0993-0025 5.79 µM 0.170846203788072 0.43115395205404 no 1410 0.432172348877141 2085 4353356
SGTC_2411 st077133 39.94 µM 0.170758977508936 0.431186083849211 no 1411 0.432206643218163 2119 1403142 YNL221C POP1
SGTC_1927 st060202 13.8 µM 0.170701768441526 0.431207158365139 no 1412 0.432229136112306 2122 688887
SGTC_72 0744-0168 198.391 µM 0.170112434684343 0.431424266873164 no 1413 0.432460857291791 1994 677577
SGTC_2953 9074162 66.49 µM 0.168448572061314 0.432037339696788 no 1414 0.433115199500841 2140 16451992
SGTC_891 0929-0073 133 µM 0.166807857500303 0.432642043616562 no 1415 0.433760617961371 2078 5603632
SGTC_2317 5986382 200 µM 0.165871187926369 0.432987334634148 no 1416 0.434129161033693 2062 877883
SGTC_3020 9089140 49.47 µM 0.164714121016117 0.433413942873024 no 1417 0.434584500917771 1995 17217859
SGTC_809 3998-0021 90 µM 0.15787850981641 0.43593578594938 no 1418 0.437276266175674 2145 715485
SGTC_1937 st074714 47.2 µM 0.156778602226774 0.436341817973348 no 1419 0.4377096686188 1959 17250970
SGTC_527 4476-4215 268 µM 0.156526765865571 0.436434793080746 no 1420 0.4378089115752 2002 4418754
SGTC_548 1436-0017 110 µM 0.156395659192686 0.436483197556955 no 1421 0.437860579268545 2133 9677137
SGTC_113 0099-0221 2.5 µM 0.154390589909478 0.437223585574712 no 1422 0.438650886433356 2120 89219
SGTC_2834 9001755 58.44 µM 0.153606165833745 0.437513300483758 no 1423 0.438960137505631 1988 2989575
SGTC_2297 7971671 152.32 µM 0.153372599903496 0.437599570930732 no 1424 0.439052225664153 2103 909016
SGTC_2493 resveratrol 26.09 µM 0.153264945802478 0.437639335295068 no 1425 0.43909467161247 2037 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase.
SGTC_1679 SEC14.276 6.7 µM 0.153078513117586 0.437708199718183 no 1426 0.439168180102565 2144 1005053 YMR079W SEC14
SGTC_3096 9117468 49.47 µM 0.152891898482637 0.437777133239493 no 1427 0.439241762434644 2136 41316311
SGTC_1187 1391-0724 117 µM 0.151225990600679 0.438392585861756 no 1428 0.439898724265562 2026 6997986
SGTC_2484 5809818 12.04 µM 0.150879834768792 0.438520488340887 no 1429 0.440035253945379 2048 2870548
SGTC_2158 5657123 3.6195 µM 0.150492533096012 0.438663601569388 no 1430 0.440188020688493 2148 2858827
SGTC_2552 juarezic acid 87.02 µM 0.149589109761789 0.438997459902738 no 1431 0.440544400326564 2180 1549512
SGTC_1875 nocodazole 6 µM 0.147433860625556 0.439794102872407 no 1432 0.441394790312474 2168 4122 A microtubule depolymerizer. YJL014W CCT3
SGTC_830 4076-0286 57.8 µM 0.146740460334199 0.440050455852367 no 1433 0.441668440768554 2057 6866659
SGTC_2698 st077697 67.5 µM 0.14605501861396 0.44030389121922 no 1434 0.441938977742424 1997 3154499
SGTC_349 k015-0014 24 µM 0.144782765483449 0.440774359114295 no 1435 0.442441194994821 2013 2196908
SGTC_2404 5161160 200 µM 0.144341992466666 0.440937372590801 no 1436 0.442615210144046 2048 2831543
SGTC_1 0258-0098 57.368 µM 0.14375255686496 0.441155382393753 no 1437 0.442847933891227 2037 6790032 YDR047W HEM12
SGTC_2648 atorvastatin 78.68 µM 0.143057013641647 0.441412660300752 no 1438 0.44312257690905 2133 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11
SGTC_1035 k081-0041 55.2 µM 0.142891481895751 0.441473893299333 no 1439 0.443187943000356 2175 731709
SGTC_2939 9044578 71.43 µM 0.141359457593839 0.442040681254947 no 1440 0.443792990374564 2082 2653634
SGTC_2628 lathosterol 100 µM 0.141263502489753 0.442076184782 no 1441 0.443830890613465 2064 6710616
SGTC_937 3122-0005 46.7 µM 0.141257478731773 0.442078413596675 no 1442 0.443833269887746 2153 759535
SGTC_2677 mitomycin C 100 µM 0.140578429314989 0.442329676348793 no 1443 0.444101494951111 2097 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_2593 nobiletin 86.24 µM 0.137899096347944 0.443321312060485 no 1444 0.445160082297897 2032 72344 An anti-infammatory.
SGTC_602 3130-1533 38.1 µM 0.137772523746983 0.443368166100605 no 1445 0.445210100059532 2156 720941
SGTC_1724 st037281 8.293 µM 0.136904571544209 0.443689481793486 no 1446 0.445553112647079 2070 574124 YDL195W SEC31
SGTC_1876 myriocin 605 nM 0.136855411190367 0.443707682054308 no 1447 0.445572541920794 2185 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1
SGTC_2528 xanthyletin 44.79 µM 0.136184423216719 0.443956108640828 no 1448 0.445837744456108 2056 65188 An natural product with antifungal activity of unknown mechanism.
SGTC_1949 st076024 69.1 µM 0.135154292362153 0.444337547114474 no 1449 0.446244942414924 2154 2921930
SGTC_1766 st045414 44.774 µM 0.132903894006942 0.445171007032681 no 1450 0.447134693627264 2153 253960
SGTC_1931 st074438 57.1 µM 0.131993748100976 0.445508158690776 no 1451 0.447494618387647 2172 2787313
SGTC_517 1365-0151 113 µM 0.131715416761082 0.445611270779351 no 1452 0.447604695475859 2075 768657
SGTC_2375 9072683 200 µM 0.131412473662366 0.445723504850435 no 1453 0.447724510839562 2194 16798029
SGTC_3255 9139072 49.47 µM 0.129891651375531 0.446287003191972 no 1454 0.448326074783421 2079 17646060
SGTC_1168 k815-0004 80.5 µM 0.129655447239149 0.446374531818402 no 1455 0.448419516444256 2101 642433
SGTC_2264 7948757 110.76 µM 0.128659044264638 0.446743791080379 no 1456 0.448813721964267 2106 2971411
SGTC_1263 0774-1208 64.8 µM 0.128123527070583 0.446942268724272 no 1457 0.449025608790099 2185 906585
SGTC_2862 9027634 71.43 µM 0.127784920982265 0.447067772468702 no 1458 0.449159591769269 2030 5012562
SGTC_3018 9082602 49.47 µM 0.126952306546611 0.447376402046255 no 1459 0.449489073441408 2084 17332089
SGTC_1412 3909-8563 178 µM 0.125284306530594 0.447994784077697 no 1460 0.450149237931654 2204 23767530
SGTC_1409 3909-8004 61.9 µM 0.125229096681881 0.448015254339525 no 1461 0.450171091368504 2086 2119279
SGTC_2440 5628896 157.78 µM 0.125116308568455 0.448057073435561 no 1462 0.450215736189953 2091 5522048
SGTC_2843 9000894 45.46 µM 0.123257524244581 0.448746348377846 no 1463 0.450951587514521 2205 2242070
SGTC_3007 9078383 71.4286 µM 0.122352882962531 0.449081863827226 no 1464 0.451309776007984 2086 6496995
SGTC_2378 9074213 121.43 µM 0.1222426869058 0.449122736088134 no 1465 0.451353410337094 2195 657714
SGTC_3189 9110682 49.47 µM 0.121868870841161 0.449261390329648 no 1466 0.451501434648294 2079 17122418
SGTC_331 k048-0133 24.5 µM 0.121848591534935 0.449268912419732 no 1467 0.451509465074955 2145 6813582
SGTC_1066 ketoconazole 628 nM 0.121514230482158 0.449392937728842 no 1468 0.451641871965399 2153 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W
SGTC_842 0271-0008 11.1 µM 0.121316691099959 0.449466213787358 no 1469 0.451720100038652 2152 1221709
SGTC_2660 2',4'-dihydroxychalcone 17.14 µM 0.120770205019688 0.449668938518111 no 1470 0.45193652513948 2155 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_325 2810-4341 181 µM 0.120045094123847 0.449937946264198 no 1471 0.452223713137623 2199 774970
SGTC_1440 4100-1550 40 µM 0.119296075135673 0.450215847790405 no 1472 0.452520396441778 2169 742806
SGTC_818 4072-2707 53.5 µM 0.116943477771903 0.451088868173018 no 1473 0.453452422111168 2181 882871
SGTC_357 1325-0123 420 µM 0.115279282061724 0.451706574205166 no 1474 0.454111879695654 2192 1098503
SGTC_2437 5741531 144.16 µM 0.115254048550247 0.451715941130104 no 1475 0.454121879756687 2199 2262990
SGTC_117 lucigenin 22.078 µM 0.114208686051504 0.452104013421685 no 1476 0.454536183246124 1969 65100 An acridine derivative; a dye stuff and potential carcinogen.
SGTC_308 4092-1169 104 µM 0.114065803617969 0.452157059555032 no 1477 0.454592815006184 2148 2268590 YDL196W YDL196W
SGTC_2194 5927483 104.545 µM 0.113884808392036 0.452224256563339 no 1478 0.454664554178525 2196 760979
SGTC_203 k066-0004 30.888 µM 0.113768623323429 0.452267392615911 no 1479 0.45471060601051 2214 6795412
SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM 0.111455755403126 0.453126208115337 no 1480 0.455627474503142 2223 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair.
SGTC_1911 st060208 74.3 µM 0.111349454188809 0.453165685247427 no 1481 0.455669620213354 2171 688783
SGTC_1093 fluphenazine 7.97 µM 0.111199118007975 0.453221516455887 no 1482 0.455729225512048 2175 6602611 An atypical antipsychotic.
SGTC_2334 9017922 200 µM 0.110203413779789 0.453591320128926 no 1483 0.456124027480972 2180 3163164
SGTC_1857 st056007 79.3 µM 0.10997829423336 0.45367493491949 no 1484 0.456213294585101 2218 619834
SGTC_2578 7,8-dihydroxyflavone 64.44 µM 0.109940355266758 0.453689026562522 no 1485 0.456228338817172 2148 1880 Intensifies effect of antibiotics on Staphylococcus aureus.
SGTC_3049 9092223 49.47 µM 0.109922467108449 0.453695670768502 no 1486 0.456235432168809 2119 8623917
SGTC_864 0469-0573 172 µM 0.109238249459229 0.453949819721919 no 1487 0.456506761570645 2030 689425
SGTC_2339 9000433 200 µM 0.10883611334173 0.454099199817977 no 1488 0.45666623981896 2057 2988954
SGTC_1948 st076329 66.6 µM 0.107886602882271 0.454451936872873 no 1489 0.457042822219885 2226 24208413
SGTC_2871 9038510 12.99 µM 0.103706231584758 0.456005341563567 no 1490 0.458701240617379 2238 4945164
SGTC_2807 7945238 51.95 µM 0.103229573158892 0.456182508579461 no 1491 0.458890384649598 2156 17148797
SGTC_2553 4-methylesculetin 85.09 µM 0.101771018324141 0.45672468620077 no 1492 0.459469215103551 2175 5319502
SGTC_1228 0124-0032 52.5 µM 0.101655658431189 0.456767571517797 no 1493 0.459514999594592 2179 X1228
SGTC_2289 7946404 165.07 µM 0.101620916459068 0.45678048702798 no 1494 0.459528788231262 2160 1246120 YPR165W RHO1
SGTC_2966 9084041 48.03 µM 0.100199779785872 0.457308841009299 no 1495 0.460092860420715 2156 17741380
SGTC_632 0781-2353 4.65 µM 0.099795318434015 0.457459226564967 no 1496 0.460253412422956 2172 6811515 YHR007C ERG11
SGTC_3066 9117245 49.47 µM 0.0981526464077647 0.458070062127624 no 1497 0.460905541758817 2189 17176980
SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM 0.0963071968886748 0.458756419553913 no 1498 0.461638297684145 2173 521171
SGTC_2061 5245884 80.95 µM 0.0959550865202415 0.458887390062776 no 1499 0.461778121830643 2210 573863
SGTC_1014 4130-3005 69.3 µM 0.0956483912479323 0.459001471669257 no 1500 0.461899915348296 2176 743608
SGTC_2427 5545055 42.75 µM 0.0950971733872744 0.459206516956634 no 1501 0.462118821606368 2171 5372858
SGTC_2160 5660466 132.927 µM 0.0948595718426878 0.459294904738031 no 1502 0.462213184328934 2246 2859134
SGTC_423 5-fluorouracil 457 µM 0.0947410446349522 0.459338997615196 no 1503 0.462260257840343 2157 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_2943 9068529 45.32 µM 0.0946511113520973 0.459372453703711 no 1504 0.462295975523286 2245 3270634
SGTC_2295 7971645 200 µM 0.0942513675513714 0.459521165908804 no 1505 0.462454740469956 2166 2978226 YKL099C UTP11
SGTC_1646 st011709 75.6 µM 0.0939368477295708 0.459638177174669 no 1506 0.462579661491843 2248 5757843
SGTC_1478 0453-0656 35.7 µM 0.0937963045336832 0.459690464794629 no 1507 0.462635483649684 2222 5258496
SGTC_1159 4092-0538 61.2 µM 0.092470458462727 0.460183766088476 no 1508 0.463162130683749 2246 717301
SGTC_368 fentichlor 4.58 µM 0.0913810003572779 0.46058916153574 no 1509 0.463594929048201 2142 7329 A pesticide.
SGTC_3283 9109332 35.8195 µM 0.0910947515716004 0.460695683646516 no 1510 0.46370865147209 2254 17027281
SGTC_572 0960-0087 17.7 µM 0.0883664069074224 0.461711126359855 no 1511 0.464792730111406 2205 6796365
SGTC_906 1165-0455 526 µM 0.0881999556209125 0.461773084797758 no 1512 0.4648588762952 2255 3252859
SGTC_633 0437-0093 97.7 µM 0.0879430759131161 0.461868705376729 no 1513 0.464960959792602 2239 2831118
SGTC_2598 perillyl alcohol 100 µM 0.0867541001272119 0.462311316849714 no 1514 0.465433486397408 2189 10819 An apoptosis inducer.
SGTC_1088 bifonazole 369 nM 0.0859833336754746 0.462598269508407 no 1515 0.465739832977663 2241 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase.
SGTC_2234 tolnaftate 200 µM 0.0856528767116361 0.462721303024056 no 1516 0.465871181665227 2260 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7
SGTC_371 0195-0006 7.36 µM 0.0842519221387151 0.463242936483479 no 1517 0.466428068500816 2198 3928593
SGTC_1514 1189-1591 158 µM 0.083935715374757 0.463360682144097 no 1518 0.466553771489724 2245 767698 YMR146C TIF34
SGTC_1436 4092-1007 8.32 µM 0.0832645716215055 0.463610606032088 no 1519 0.466820585095132 2251 2881121
SGTC_1037 k284-1091 78.7 µM 0.0826013015403239 0.463857611992939 no 1520 0.467084283167162 2251 3334711
SGTC_1699 st031318 29.054 µM 0.0817125492646229 0.464188610769811 no 1521 0.467437649431689 2227 5340658
SGTC_80 0159-0065 512.242 µM 0.0813683489089783 0.464316808276483 no 1522 0.46757450976713 2259 1548079
SGTC_1375 2910-0797 186 µM 0.0811403817477199 0.464401716741584 no 1523 0.467665155776851 2196 742508
SGTC_1915 st067105 30.6 µM 0.0800397804554818 0.464811668549653 no 1524 0.468102808608733 2252 69751 YOR207C | YOR116C RET1 | RPO31
SGTC_1649 st011737 51.3 µM 0.0781215480845132 0.465526260493656 no 1525 0.46886568334073 2162 1761035
SGTC_2224 6650123 117.647 µM 0.0771220414820828 0.465898647159394 no 1526 0.469263229325977 2248 2908370
SGTC_1351 1496-0003 46.5 µM 0.0762752672258756 0.466214153637464 no 1527 0.469600051202006 2251 3891978
SGTC_2144 5628481 200 µM 0.0758846571958874 0.46635970136089 no 1528 0.469755431722087 2227 2818399
SGTC_971 1315-0384 26.7 µM 0.0748155947987073 0.466758074548232 no 1529 0.47018071686893 2183 6769120
SGTC_3316 9136639 10.545 µM 0.073742986111364 0.467157802687284 no 1530 0.470607446955874 2203 4903665
SGTC_342 k048-0088 23.3 µM 0.0733861610239851 0.467290787742139 no 1531 0.470749414901724 2261 6820570
SGTC_1387 3342-1166 1.8 µM 0.0722290411172827 0.467722059519048 no 1532 0.471209817028207 2201 3418228
SGTC_1026 k007-1105 30.6 µM 0.0721795437613386 0.467740508596382 no 1533 0.471229512209269 2277 7066794
SGTC_681 1642-0006 26.6 µM 0.0720419235554136 0.467791803939172 no 1534 0.47128427216802 2292 4446530
SGTC_322 k048-0136 19.3 µM 0.0705319674166818 0.46835464662357 no 1535 0.471885128789913 2224 6823282
SGTC_2361 9034121 116 µM 0.0690325784603942 0.468913612946343 no 1536 0.472481843742126 2200 6496917
SGTC_2377 9073351 62.6 µM 0.0687824344372663 0.469006871651484 no 1537 0.472581400129057 2217 7337946 YHR072W ERG7
SGTC_3325 9138760 55.175 µM 0.0685248956532404 0.469102889048312 no 1538 0.472683901392782 2242 43844959
SGTC_1240 0356-0016 42.1 µM 0.068218885035831 0.469216980386153 no 1539 0.472805696953095 2230 4305613
SGTC_1334 1486-0610 236 µM 0.0669853814324961 0.469676898709996 no 1540 0.473296670493267 2233 3742339
SGTC_3115 9123671 49.47 µM 0.0666509164392976 0.469801612745014 no 1541 0.473429805186871 2303 3286988
SGTC_3125 9127534 49.47 µM 0.0664836714119389 0.469863975546776 no 1542 0.473496378635586 2307 1639235
SGTC_835 0312-0010 67.2 µM 0.0664544725119904 0.469874863391524 no 1543 0.473508001606992 2273 1626196
SGTC_472 calcifediol 10 µM 0.0653896104539525 0.470271950275802 no 1544 0.473931898016746 2194 5283731 A vitamin D metabolite.
SGTC_2566 crystal violet carbinol 226 nM 0.0652454994338643 0.470325691531139 no 1545 0.473989267484996 2086 68050 Cationic dye that binds acidic phospholipids including cardiolipin.
SGTC_2913 7966556 36.57 µM 0.0642217037567816 0.470707496467744 no 1546 0.474396847983417 2287 2976516
SGTC_2129 girgensonine 121.053 µM 0.064021610402607 0.470782120598315 no 1547 0.47447650974571 2243 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_565 1418-0001 44.5 µM 0.0625352225737488 0.471336495788343 no 1548 0.475068306630386 2283 2862145
SGTC_1042 0350-0096 82 µM 0.062428995400632 0.471376117270787 no 1549 0.475110602498587 2240 3122515
SGTC_802 4112-3352 742 µM 0.0615624141913639 0.471699352387043 no 1550 0.47545565463571 2260 704594
SGTC_2621 lithochol-11-enic acid 100 µM 0.0607597501466673 0.471998763012001 no 1551 0.47577527289765 2294 6708711
SGTC_2230 bromochlorosalicylanilide 954.5 nM 0.0599684332942289 0.47229395638658 no 1552 0.476090388003841 2295 77254
SGTC_1904 st060225 78 µM 0.0594953472847619 0.472470443991458 no 1553 0.476278785621757 2300 66595
SGTC_992 3909-8734 162 µM 0.0589387703327197 0.472678085316286 no 1554 0.476500438725427 2264 4288319
SGTC_1688 st021091 57.6 µM 0.0588415321495311 0.472714362582268 no 1555 0.476539163939214 2310 3656366
SGTC_2280 7785178 200 µM 0.0583046077201858 0.472914680453015 no 1556 0.476752998665527 2266 2954328
SGTC_348 k064-0012 10.7 µM 0.0580399488129168 0.473013422959177 no 1557 0.476858403796031 2287 5066323
SGTC_1842 st055362 61.2 µM 0.0572794465801273 0.473297170572975 no 1558 0.477161296360539 2215 676032
SGTC_1738 st035555 74 µM 0.057072152827694 0.473374515381198 no 1559 0.477243859539856 2266 5331140
SGTC_646 4092-0839 27.3 µM 0.0569905113006641 0.473404977492686 no 1560 0.477276376871297 2272 877796
SGTC_2964 9083345 53.42 µM 0.0556429375860336 0.473907806945082 no 1561 0.477813129111647 2252 17741579
SGTC_715 0868-0130 184 µM 0.0544560264164166 0.47435072173636 no 1562 0.478285921204234 2300 2876258
SGTC_2203 7227154 166.4 µM 0.0538209444585724 0.474587725731004 no 1563 0.478538911218912 2315 896304
SGTC_1643 st009866 20.2 µM 0.0535829159577464 0.474676557068771 no 1564 0.478633734023367 2308 3156273 YOR207C RET1
SGTC_3259 9138485 49.47 µM 0.0527672772198773 0.474980959887279 no 1565 0.478958667078674 2306 17646153
SGTC_3170 9103054 49.47 µM 0.0527392376511509 0.474991424736461 no 1566 0.478969837693957 2262 16432970
SGTC_1081 sertraline 6 µM 0.0520567973855287 0.475246128480794 no 1567 0.479241718476748 2323 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1
SGTC_2236 dapsone 200 µM 0.0520264853980727 0.475257441906672 no 1568 0.479253794845658 2323 2955 A bacterial DFR inhibitor. An anti-cancer agent.
SGTC_3340 9146634 11.102 µM 0.0515169790312061 0.475447609338408 no 1569 0.479456786252795 2238 4907387
SGTC_3070 9117005 49.47 µM 0.0511190107389944 0.47559615035053 no 1570 0.47961534370882 2318 8779016
SGTC_2307 7538926 6.34 µM 0.0508558504558175 0.475694376358702 no 1571 0.479720193093962 2240 96582
SGTC_1573 oleylamine 1.06 µM 0.0486696042666099 0.476510461198388 no 1572 0.480591299719619 2287 5356789 An amine of the fatty acid oleic acid.
SGTC_140 0062-0056 502.533 µM 0.0478812164817016 0.476804775974311 no 1573 0.480905454647453 2317 3758964
SGTC_309 k408-0051 1.48 µM 0.0475852135857501 0.476915280741452 no 1574 0.481023408264479 2284 3640463
SGTC_468 gf-109203x 121 µM 0.0457379713124382 0.477604939027636 no 1575 0.481759549366955 2326 2396 A protein kinase C inhibitor.
SGTC_1837 st055472 66.5 µM 0.0452372419893513 0.477791895355052 no 1576 0.481959104903647 2292 676091
SGTC_2425 5628681 7.85 µM 0.043580410060363 0.478410538065308 no 1577 0.482619433683385 2300 5714958
SGTC_2057 5236571 38.335 µM 0.0428625806717974 0.47867858385571 no 1578 0.482905538809459 2311 54684039 YBR257W POP4
SGTC_2107 5363541 170.161 µM 0.0422903347937009 0.478892273994982 no 1579 0.483133625055977 2340 244052
SGTC_3151 9099821 49.47 µM 0.0422062419121806 0.478923676777776 no 1580 0.483167143334847 2283 17174189
SGTC_3162 9099653 49.47 µM 0.042130457299763 0.478951977117896 no 1581 0.48319735015257 2335 25237511
SGTC_1347 1493-0251 600 nM 0.0418810818156851 0.479045102456988 no 1582 0.483296748844178 2333 3986378
SGTC_2127 5253358 187.912 µM 0.0412745805762332 0.47927159553777 no 1583 0.48353849877918 2316 20612
SGTC_3240 9133527 49.47 µM 0.0408122399140697 0.479444257493526 no 1584 0.483722790724675 2316 17617455
SGTC_1612 st002233 45.4 µM 0.040640936683692 0.479508231975546 no 1585 0.483791074173129 2331 1035021
SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM 0.0405846828869473 0.479529240494987 no 1586 0.483813497690774 2285 2374 Ca(2+)-ATPase inhibitor.
SGTC_1502 4534-4282 27.7 µM 0.0404094074756678 0.479594699141266 no 1587 0.483883365147775 2303 3278949
SGTC_2506 ethyl hematommate 54.16 µM 0.040334755854416 0.479622578826968 no 1588 0.483913122575012 2168 3940691 An allergen.
SGTC_1971 st069429 63.5 µM 0.0400116418577481 0.479743251388519 no 1589 0.484041922433029 2340 1246522 YGL099W LSG1
SGTC_1723 st034307 2.5525 µM 0.0399919836776254 0.479750593139017 no 1590 0.484049758640193 2320 867466
SGTC_942 3253-1115 227 µM 0.0396559365681409 0.479876097883781 no 1591 0.484183715773106 2324 46497897
SGTC_87 0100-0052 35.5 µM 0.0393619652583524 0.479985890061957 no 1592 0.484300901860449 2328 200187 YGR083C | YDR527W GCD2 | RBA50
SGTC_202 3594-0513 34.79 µM 0.0392447470691884 0.480029669044795 no 1593 0.484347629047171 2329 708429
SGTC_1447 4239-0816 81.9 µM 0.0382495713600178 0.480401359751717 no 1594 0.484744348779756 2302 1341554
SGTC_2810 7959871 45.46 µM 0.0377423800229033 0.480590798510099 no 1595 0.484946542840335 2302 2974535
SGTC_558 k064-0027 21.3 µM 0.0370220761278627 0.48085984350582 no 1596 0.485233701800076 2307 5088526
SGTC_2074 5212007 75.395 µM 0.0351072564305995 0.481575101276567 no 1597 0.485997107592892 2356 758611
SGTC_2746 daunorubicin 9.88 µM 0.0345416985723727 0.481786370033826 no 1598 0.486222595760349 2343 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_1266 0828-0227 32.9 µM 0.0339066316078761 0.4820236105794 no 1599 0.486475802485996 2314 3913820
SGTC_1986 st071812 45 µM 0.0334722312339283 0.482185892227106 no 1600 0.486649004842117 2343 11838594
SGTC_2244 6635614 200 µM 0.0332479067693234 0.482269695669013 no 1601 0.486738447571391 2305 836499
SGTC_886 0866-0150 153 µM 0.032652997100957 0.482491946624767 no 1602 0.486975653381664 2349 271463
SGTC_544 k015-0020 52.4 µM 0.0322138190344626 0.482656021658831 no 1603 0.4871507679516 2306 3008304
SGTC_2788 5282734 71.43 µM 0.0315912208214441 0.48288862669684 no 1604 0.487399022333291 2344 743706
SGTC_2093 5331342 194.4 µM 0.0310405744085035 0.483094355127384 no 1605 0.487618590776003 2349 33839
SGTC_1090 efavirenz 20.7 µM 0.0307771651431454 0.483192769739287 no 1606 0.487723625683734 2277 64139 A non-nucleoside reverse transcriptase inhibitor.
SGTC_195 4234-0266 16.654 µM 0.0307051992705146 0.483219657709218 no 1607 0.487752322350396 2327 2303354
SGTC_858 0438-0351 2.77 µM 0.0300424458845064 0.483467279943415 no 1608 0.488016600757052 2327 2799119
SGTC_2671 danthron 100 µM 0.0299469247790834 0.483502969688631 no 1609 0.488054691026258 2324 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin.
SGTC_2067 5224629 34.075 µM 0.0296466896926247 0.483615147994955 no 1610 0.488174414335905 2313 2835000
SGTC_2446 5162541 200 µM 0.0291397560432616 0.483804559037135 no 1611 0.488376564256087 2356 1549321
SGTC_3352 9151559 45.5865 µM 0.0278609588367166 0.484282385859489 no 1612 0.488886523340712 2332 17159339
SGTC_1897 st060201 15 µM 0.0277070765865934 0.484339886008284 no 1613 0.488947889785893 2322 611878
SGTC_1587 estradiol valerate 56.1 µM 0.0270106230959552 0.484600129169907 no 1614 0.489225630559168 2360 13791 A steroid.
SGTC_1810 st050138 53 µM 0.0269414803497791 0.484625966038663 no 1615 0.489253204489293 2362 3444541
SGTC_2461 5755302 26.15 µM 0.0268879510558886 0.484645968605566 no 1616 0.489274551854427 2353 2788904
SGTC_1246 0422-0085 105 µM 0.0268200388762161 0.484671345755063 no 1617 0.489301635127111 2348 264295
SGTC_1435 4092-0789 56.7 µM 0.0267152022211038 0.484710520815537 no 1618 0.489343443920553 2362 2248285
SGTC_2458 5808907 16.39 µM 0.0266798425860967 0.484723733935789 no 1619 0.489357545347631 2361 2731747
SGTC_3084 9116877 49.47 µM 0.0264139543049551 0.484823091092459 no 1620 0.489463582053907 2360 27241325
SGTC_405 ebelactone b 50 µM 0.0259443330319565 0.484998581509829 no 1621 0.489650869644217 2315 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).
SGTC_1531 st059297 52.4 µM 0.0256940906728937 0.485092094510302 no 1622 0.489750668631206 2349 7566702
SGTC_1976 st070609 63.5 µM 0.0254416434736729 0.485186432267636 no 1623 0.489851347579187 2359 682556
SGTC_2341 7987486 176.74 µM 0.0247098030517591 0.48545992059505 no 1624 0.490143217882217 2353 1258686
SGTC_122 0236-0016 402.397 µM 0.0235451601853637 0.485895160987131 no 1625 0.490607707919229 2357 6808838
SGTC_3212 9128307 49.47 µM 0.0217833235467637 0.486553611306568 no 1626 0.491310398456717 2305 27243542
SGTC_647 0140-0236 81 µM 0.0202227483372188 0.487136874967497 no 1627 0.491932840523098 2347 990837
SGTC_702 1488-0190 94 µM 0.0187573360256495 0.487684596648962 no 1628 0.492517344374245 2374 949357
SGTC_1328 1441-0025 69.2 µM 0.0184205921607331 0.487810463464293 no 1629 0.492651662530195 2374 4562601
SGTC_2699 st077704 54.6 µM 0.0167864169725089 0.48842129613993 no 1630 0.49330350302875 2369 645852
SGTC_2646 retinol 96.75 µM 0.0158104909394247 0.488786097192371 no 1631 0.493692789462064 2364 445354 A vitamin A analog and teratogen.
SGTC_3063 1327-0034 4 µM 0.0153638274257539 0.488953063116564 no 1632 0.493870960775775 2365 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_419 nsc-638432 893 µM 0.0153172719386138 0.488970465992971 no 1633 0.493889531542698 2358 368090
SGTC_485 niflumic acid 177 µM 0.0152514809322523 0.488995059322121 no 1634 0.493915775291192 2375 4488 A COX2 inhibitor.
SGTC_2006 4011487 200 µM 0.0149865549259273 0.489094091707143 no 1635 0.494021453397095 2372 45595294
SGTC_2147 5545932 89.7195 µM 0.0143400041606147 0.489335782622266 no 1636 0.494279362101119 2370 797404
SGTC_3168 9103419 49.47 µM 0.0127837582769268 0.489917547865221 no 1637 0.494900157227802 2386 16649256
SGTC_1825 st052143 62.6 µM 0.0110303739878198 0.490573034214699 no 1638 0.495599606679819 2380 674173
SGTC_1146 3579-1023 7 µM 0.0102327806695944 0.490871215562812 no 1639 0.495917782386314 2386 X1146
SGTC_401 neomycin 50 µM 0.00996337713096241 0.490971933603509 no 1640 0.496025253368427 2333 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis.
SGTC_81 0411-0046 9.971 µM 0.00891629636580375 0.491363396093238 no 1641 0.496442959526142 2387 12925265
SGTC_2897 9048598 12.99 µM 0.0085323823524945 0.491506928611117 no 1642 0.49659611322846 2385 6467404
SGTC_230 MPP+ 141.667 µM 0.00772100083891569 0.491810280424027 no 1643 0.496919796922168 2376 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death.
SGTC_2587 piperic acid 92.2 µM 0.00722502904668673 0.491995712112473 no 1644 0.497117655513069 2385 5370536
SGTC_2754 granisetron 64.02 µM 0.00599824406514602 0.49245438427413 no 1645 0.497607061183485 2388 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients.
SGTC_641 4092-0595 30 µM 0.00386541753683856 0.493251831968344 no 1646 0.49845792535329 2395 786260
SGTC_981 1488-1094 54.9 µM 0.00289168092817921 0.493615913874443 no 1647 0.498846387824035 2399 3449522
SGTC_1264 0783-0040 158 µM 0.00267182462157307 0.493698119297981 no 1648 0.498934097460821 2398 2855798
SGTC_2610 ononetin 44.17 µM 0.00261867556824413 0.493717992047448 no 1649 0.498955300791171 2397 259632
SGTC_2294 7971431 200 µM 0.00135395633327091 0.49419088263557 no 1650 0.499459849737875 2402 5741572
SGTC_465 cgp-37157 41 µM 0.000469204339797112 0.494521704739598 no 1651 0.499812814557575 2404 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange.
SGTC_286 k060-0067 22.9 µM 0.00045570859905816 0.4945267510302 no 1652 0.499818198578586 2404 5985051
SGTC_272 doxorubicin 8.13 µM 0 0.494697148856711 no 1653 0.5 2405 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_1557 sumaresinolic acid 42.3 µM -0.000465607008966545 0.494871248879802 no 1654 0.499814249684783 2408 9982268 A natural terpine and antifungal of unknown mechanisn.
SGTC_453 enantio-paf c16 10 µM -0.00125835138155279 0.49516767451142 no 1655 0.499497990562781 2408 13871343 A lipid and platelet activating factor
SGTC_1078 idebenone 36.1 µM -0.00213281541169424 0.495494660119563 no 1656 0.49914913040107 2412 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen.
SGTC_1594 piperine 70.1 µM -0.00394724687982121 0.496173134226011 no 1657 0.498425280417679 2412 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_394 menadione 8.33 µM -0.00441968463505809 0.496349795747344 no 1658 0.498236806673292 2410 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_3156 9099931 49.47 µM -0.00452749258469696 0.496390109130779 no 1659 0.498193797954408 2418 18111053
SGTC_3119 9125183 49.47 µM -0.00502608784516029 0.496576552829745 no 1660 0.497994889495594 2411 22695334
SGTC_1788 fluconazole 20 µM -0.00540290165573875 0.496717458319004 no 1661 0.497844564579357 2430 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11
SGTC_1004 4084-0029 199 µM -0.00621347826619762 0.497020566127301 no 1662 0.497521196761257 2419 716894 YLR208W SEC13
SGTC_307 1501-1223 22.3 µM -0.00680194850251433 0.497240620349054 no 1663 0.497286436077769 2419 2830329
SGTC_1123 mangostin 811.285 nM -0.00682803881318336 0.497250376653424 no 1664 0.497276027791439 2432 5281650 An antioxidant.
SGTC_1772 st048439 82.2 µM -0.00712863735402003 0.497362783667325 no 1665 0.497156109244409 2424 2927068 YDL195W SEC31
SGTC_1124 fisetin 1.16336 µM -0.00817676363920113 0.49775472575894 no 1666 0.496737979617003 2436 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster.
SGTC_877 0771-0151 33.1 µM -0.00838937945621127 0.497834232760331 no 1667 0.496653161087994 2444 6166523
SGTC_545 4218-0007 221 µM -0.00909939377765389 0.498099740939177 no 1668 0.496369917190659 2428 2840508
SGTC_2020 4017018 200 µM -0.00915073167911297 0.498118938660236 no 1669 0.496349437183852 2417 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope.
SGTC_76 0433-0009 400.328 µM -0.00972038193421025 0.498331958687932 no 1670 0.49612218973124 2463 2841569
SGTC_1250 0485-0349 40.2 µM -0.0105863675856912 0.498655793871537 no 1671 0.495776729258832 2435 6842794 YDL195W SEC31
SGTC_1673 st016611 27.3 µM -0.010866926808505 0.498760709144336 no 1672 0.495664808762087 2440 5226799
SGTC_303 1348-1668 34.2 µM -0.0119872312349479 0.499179648371553 no 1673 0.495217901161961 2434 5380509
SGTC_2816 7982706 58.44 µM -0.0123985950167006 0.49933347861855 no 1674 0.495053802956409 2449 2981853
SGTC_1165 k072-0275 30.3 µM -0.0128763857722728 0.499512149478115 no 1675 0.494863207244902 2435 6153523 YGL055W OLE1
SGTC_3327 9140648 26.9345 µM -0.0128811023282912 0.49951391324472 no 1676 0.494861325767327 2433 8029710
SGTC_109 0132-0036 33.701 µM -0.0139957959167663 0.49993075558018 no 1677 0.494416667540864 2426 67274 A color developer.
SGTC_2302 7771753 200 µM -0.0141707821666905 0.499996192125652 no 1678 0.494346865049992 2445 2203047
SGTC_2586 curcumin 80 µM -0.0141911477175913 0.499996192125652 no 1679 0.494338741187569 2441 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40
SGTC_1515 3460-0031 42.1 µM -0.0155693503563651 0.499480809948399 no 1680 0.493788978795568 2436 2876596
SGTC_1523 st012844 44.7 µM -0.0164551900698013 0.499149548469553 no 1681 0.493435625193334 2478 4274103
SGTC_2161 5662504 8.5105 µM -0.0169308949665491 0.498971657928272 no 1682 0.493245872838633 2459 2859334
SGTC_2626 ethyl orsellinate 100 µM -0.0177525349531505 0.49866440495639 no 1683 0.492918135202734 2451 75653 A natural product.
SGTC_1627 st003713 25.6 µM -0.0186880728569904 0.498314560736296 no 1684 0.49254497153806 2448 16195070 YER133W GLC7
SGTC_2279 7948423 32.93 µM -0.021279590974391 0.497345470629125 no 1685 0.491511312098181 2440 1247112
SGTC_1697 st025554 27.742 µM -0.0215255590265382 0.497253492368405 no 1686 0.491413207514766 2443 1269519
SGTC_3093 9117344 49.47 µM -0.0216518364623027 0.497206271743882 no 1687 0.49136284184499 2546 24824913
SGTC_2045 5106652 78.05 µM -0.0222850642104665 0.496969480955974 no 1688 0.491110281479131 2446 673349
SGTC_2769 toremifene 3.73 µM -0.0250039531266407 0.495952785923389 no 1689 0.49002590522824 2484 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_2166 5933061 31.504 µM -0.0252833895784843 0.495848295480662 no 1690 0.489914461446459 2503 2877375
SGTC_261 5-fluorouridine 15.376 µM -0.0255878549363518 0.495734446234597 no 1691 0.489793036628272 2471 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_837 0091-0265 12.5 µM -0.0256523821493924 0.495710317509025 no 1692 0.489767302441981 2452 759367
SGTC_2916 7875993 68.79 µM -0.0312970497870251 0.493599671846504 no 1693 0.487516321592969 2470 1299250
SGTC_1462 k081-0014 26.5 µM -0.0322553193857175 0.493241373281024 no 1694 0.487134220306128 2440 3270634
SGTC_2412 st077135 33.4 µM -0.0324420689636409 0.49317154793515 no 1695 0.48705975697458 2657 13258915
SGTC_1534 6-azauridine 81.6 µM -0.0334852542986521 0.49278150664202 no 1696 0.486643812301761 2464 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1
SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM -0.0340216139126897 0.492580967377777 no 1697 0.486429957633192 2450 91467 include heat shock
SGTC_2358 9037157 4 µM -0.0342682148875673 0.492488766472053 no 1698 0.486331635410602 2504 2388925
SGTC_1570 verbenone 133 µM -0.0344645043829418 0.492415376662498 no 1699 0.486253373460981 2479 29025 A natural terpanoid with antifungal properties.
SGTC_1299 1079-1439 3.74 µM -0.03448952884816 0.492406020394495 no 1700 0.486243396075406 2475 323161
SGTC_1602 st001878 87.6 µM -0.0358997138735351 0.491878780506359 no 1701 0.485681162008813 2595 595405 YLR310C CDC25
SGTC_1503 4585-0012 61.3 µM -0.0359738099049248 0.491851077871119 no 1702 0.485651621050597 2511 2922052
SGTC_409 arachidonic acid 100 µM -0.0361980851364242 0.491767227265004 no 1703 0.485562206415122 2469 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes.
SGTC_2540 epiandrosterone 100 µM -0.0382769570970828 0.490990009555715 no 1704 0.484733431446198 2486 441302 A steroid.
SGTC_1901 st060216 58.6 µM -0.0410387734363677 0.489957516175465 no 1705 0.483632492576621 2472 688792
SGTC_2462 5162487 171.77 µM -0.0410569871260881 0.489950707280192 no 1706 0.483625232484654 2465 2259986
SGTC_3192 9110362 49.47 µM -0.0442019784869032 0.488775048401549 no 1707 0.482371702496073 2481 16649480
SGTC_2201 6605497 169.863 µM -0.0449807485665127 0.48848394368342 no 1708 0.482061326919682 2536 670741
SGTC_1272 0839-0021 27 µM -0.0454970311916742 0.488290960303754 no 1709 0.481855570607938 2536 5027250
SGTC_1050 3232-1156 69.3 µM -0.0455659339836584 0.488265205055612 no 1710 0.481828110849372 2517 700529
SGTC_3217 9129673 49.47 µM -0.0455754417585058 0.488261651138146 no 1711 0.481824321732442 2533 17248312
SGTC_2674 ligustilide 100 µM -0.0455918177987869 0.488255529929373 no 1712 0.481817795421516 2524 5319022 A signalling regulator.
SGTC_1488 4013-0813 75.9 µM -0.0457572941192302 0.488193676603353 no 1713 0.481751848744676 2485 2910057
SGTC_756 0508-1999 28.3 µM -0.0460738662914044 0.488075346013367 no 1714 0.481625687779869 2499 6753853
SGTC_52 0329-0193 875 nM -0.0471427528226236 0.487675817847477 no 1715 0.48119972668622 2645 3739292
SGTC_1120 ficusin 1.78878 µM -0.0471558576411775 0.487670919607289 no 1716 0.481194504427938 2605 6199 A DNA cross-linker.
SGTC_458 nppb 133 µM -0.0473100331353949 0.487613292959051 no 1717 0.481133065876195 2502 4549 A chloride channel blocker.
SGTC_1751 st044839 27.194 µM -0.0476322761392787 0.487492848037844 no 1718 0.481004654287915 2484 5291326
SGTC_1121 fusaric acid 630.51 nM -0.0482223740088593 0.487272289840855 no 1719 0.48076950952383 2522 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler.
SGTC_1232 0279-0259 161 µM -0.0485349167110449 0.48715547374912 no 1720 0.480644968854618 2503 1560000
SGTC_1182 1222-0449 220 µM -0.0503917421105352 0.486461488969908 no 1721 0.479905108434421 2530 658318
SGTC_573 3702-0553 84.7 µM -0.0506659937332177 0.48635899139874 no 1722 0.47979583744959 2498 1222756
SGTC_133 0724-0033 378.92 µM -0.0511452012449536 0.486179896700009 no 1723 0.479604908858486 2494 280309
SGTC_1138 3761-0006 1.03 µM -0.051455406777183 0.486063964762654 no 1724 0.479481317492614 2481 12061087
SGTC_1108 betulinic acid 729.144 nM -0.0519613304910045 0.485874890342721 no 1725 0.479279752782227 2511 64945 Apoptosis-inducing agent of unknown mechanism.
SGTC_1690 st023502 41.2 µM -0.0525333848767946 0.485661105315684 no 1726 0.479051847383061 2503 24207482
SGTC_1358 1509-0022 2.48 µM -0.0526278833432843 0.485625790262134 no 1727 0.479014200027602 2530 3258434
SGTC_2857 9024691 58.44 µM -0.0535193600382354 0.485292641794513 no 1728 0.478659052837097 2567 16478292
SGTC_1532 4',5'-dihydroxyflavone 78.7 µM -0.0536073980293015 0.485259742192239 no 1729 0.478623981107313 2495 165521
SGTC_1820 st053765 18.6 µM -0.0542735740324796 0.485010796963353 no 1730 0.478358601690115 2548 3690829
SGTC_161 4065-0411 162.148 µM -0.0560768553913983 0.484336953146879 no 1731 0.477640290820767 2561 1906281 YLR208W SEC13
SGTC_1654 st012436 41.8 µM -0.0587221616520058 0.483348545911489 no 1732 0.476586703674537 2512 4323132
SGTC_3205 9113483 49.47 µM -0.0592320580067036 0.483158036920016 no 1733 0.476383637931235 2574 17018033
SGTC_959 1222-0044 107 µM -0.0596165320386074 0.483014391129927 no 1734 0.476230525562716 2525 6083612
SGTC_2856 9022925 19.48 µM -0.0596794303241568 0.482990891510496 no 1735 0.476205477376149 2593 4944862
SGTC_2986 9022445 71.43 µM -0.0614954751041882 0.482312419315612 no 1736 0.47548230896588 2499 6459286
SGTC_1910 st062352 60.4 µM -0.0627589526582511 0.481840415683978 no 1737 0.47497922621715 2508 2245730
SGTC_1269 0831-0796 3.05 µM -0.0628108181776571 0.481821040561758 no 1738 0.474958575610449 2553 927758
SGTC_1584 6-fluoro-dl-tryptophan 90 µM -0.0639689575904796 0.481388411939257 no 1739 0.474497472209869 2671 94937 An inhibitor of serotonin biosynthesis.
SGTC_788 1182-0090 188 µM -0.0640570339005334 0.481355511494752 no 1740 0.47446240676275 2720 5715185
SGTC_772 k072-0172 35.3 µM -0.0647121594760037 0.481110796766135 no 1741 0.474201590627513 2542 5861980
SGTC_2309 7664088 163.95 µM -0.0648096738389335 0.481074371988181 no 1742 0.474162769518031 2533 704922
SGTC_1312 1218-2183 165 µM -0.0651686598379561 0.480940280435779 no 1743 0.474019856946794 2503 6744073
SGTC_566 0958-0068 16.5 µM -0.0653967844938117 0.480855070462736 no 1744 0.473929042101789 2548 6815365
SGTC_3211 9128781 49.47 µM -0.0659965089729796 0.480631063319172 no 1745 0.473690302416478 2643 17194361
SGTC_1025 k007-0731 70 µM -0.0673131265907334 0.480139306125441 no 1746 0.473166213541479 2530 6256118
SGTC_1437 4092-1038 11.6 µM -0.0705191385928839 0.478941987294585 no 1747 0.471890234037954 2536 3977136
SGTC_1011 4112-3381 17.4 µM -0.0717195015367128 0.478493747462894 no 1748 0.47141256807236 2688 2877139
SGTC_1394 3474-0001 65.7 µM -0.0717670138199873 0.478476005970058 no 1749 0.471393662131724 2583 5017666 YIL048W NEO1
SGTC_1645 Cervolide 78 µM -0.0719196730673265 0.478419001990613 no 1750 0.471332916873279 2592 23173 A fragrance.
SGTC_2015 5119600 184 µM -0.0724802124432803 0.478209696650724 no 1751 0.471109876114528 2587 2828786
SGTC_2723 salbutamol 83.58 µM -0.07254692574485 0.478184786310493 no 1752 0.471083331239061 2557 9884233 β2-adrenoceptor agonist
SGTC_1782 st039423 80.636 µM -0.073390309409938 0.477869879371217 no 1753 0.470747764385864 2578 2068169
SGTC_2385 9074692 200 µM -0.0747470561374564 0.477363319360885 no 1754 0.470207983491212 2555 17046906
SGTC_1231 0242-0792 125 µM -0.075014948755209 0.477263302273346 no 1755 0.470101409009262 2525 3707635
SGTC_536 3852-0578 10.6 µM -0.0751506439560117 0.477212641330877 no 1756 0.47004742683138 2648 2869208
SGTC_2952 9073731 13.78 µM -0.0777843933487962 0.476229421635346 no 1757 0.468999780567622 2560 16457353
SGTC_1861 st057647 17.4 µM -0.0779044511984486 0.476184605572199 no 1758 0.468952029315157 2694 688668
SGTC_2371 9071574 200 µM -0.0783355682231774 0.476023677575814 no 1759 0.468780562514879 2528 45596039
SGTC_3324 9138759 60.749 µM -0.0793715185946217 0.475636992538561 no 1760 0.468368561011071 2639 45595710
SGTC_388 3',4'-dichloroisocoumarin 16.7 µM -0.0801310880856596 0.475353485641825 no 1761 0.468066498761259 2648 1609 A potent and irreversible inhibitor of serine proteases.
SGTC_2875 9039966 71.43 µM -0.0804794475254443 0.475223465753964 no 1762 0.467927970852387 2645 6463691
SGTC_2460 5552655 174.22 µM -0.0815530340281764 0.474822782498 no 1763 0.46750107511972 2669 5401989
SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM -0.0829349053259542 0.474307078929529 no 1764 0.466951649598777 2532 6708784 An antioxidant flavonoid
SGTC_1459 k035-0031 35.7 µM -0.0834115251346877 0.474129218082763 no 1765 0.466762162357874 2542 3877128 YMR208W ERG12
SGTC_3129 9127257 49.47 µM -0.0841918566526075 0.473838031882672 no 1766 0.466451946325852 2579 837894
SGTC_2896 9052656 71.43 µM -0.0848663385651266 0.473586355464239 no 1767 0.466183826572128 2562 6469436
SGTC_1033 k072-0102 21.3 µM -0.0850230354406214 0.473527887042391 no 1768 0.466121538691425 2544 5965931
SGTC_3214 9129694 49.47 µM -0.0856326895437907 0.473300411789926 no 1769 0.465879205699091 2591 17158655
SGTC_549 1661-1316 519 µM -0.0873358056787047 0.472664988354607 no 1770 0.465202296963347 2591 2857282
SGTC_2310 7668677 200 µM -0.0880018003198673 0.472416528178597 no 1771 0.464937622623731 2644 2197143
SGTC_189 3970-0742 2.116 µM -0.0886222047889622 0.472185085814565 no 1772 0.46469108032382 2572 2891807
SGTC_1303 1160-0052 261 µM -0.0888864717857364 0.472086503655982 no 1773 0.464586067471983 2560 3562476
SGTC_3229 9132204 49.47 µM -0.0895387823974475 0.471843173042668 no 1774 0.464326866724157 2569 17682924
SGTC_2002 4023503 131 µM -0.0896536867655395 0.471800311495754 no 1775 0.464281210135602 2556 4736863 YCR052W RSC6
SGTC_508 roscovitine 141 µM -0.0909419542209544 0.471319785344321 no 1776 0.463769356822142 2567 160355 A CDKinase inhibitor.
SGTC_2669 eugenol 100 µM -0.091685523199971 0.471042451693777 no 1777 0.463473949876588 2552 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism.
SGTC_908 3448-7491 47.7 µM -0.0918651964564135 0.470975439918263 no 1778 0.463402571850331 2580 1203031
SGTC_2121 5257820 149.641 µM -0.0930077205192724 0.470549338123733 no 1779 0.462948713862229 2595 791256
SGTC_3253 9135987 49.47 µM -0.0932238171216843 0.470468749155982 no 1780 0.462862876726281 2653 4182430
SGTC_1212 0520-0165 585 µM -0.09349376377507 0.470368079572817 no 1781 0.462755651891308 2850 5403258
SGTC_588 3970-1144 52.9 µM -0.0946269437123592 0.469945510323707 no 1782 0.462305573935893 2682 1888707
SGTC_2806 7952793 58.44 µM -0.0952451464725791 0.469714993233678 no 1783 0.462060055627767 2679 2972490
SGTC_1040 k898-0338 155 µM -0.0966039742638031 0.46920834569361 no 1784 0.461520450126818 2573 20969351
SGTC_2607 solasodine 47.35 µM -0.0970198004985369 0.46905331217574 no 1785 0.46135533505151 2614 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity.
SGTC_1330 1469-0054 61.8 µM -0.0975759736182417 0.468845960122659 no 1786 0.461134501860044 2700 7102664
SGTC_3103 9120822 49.47 µM -0.0990383933409465 0.468300782344465 no 1787 0.46055389323056 2733 17141819
SGTC_1796 st049173 110.4 µM -0.0995103838350998 0.468124840895282 no 1788 0.460366521857179 2571 94134
SGTC_347 4534-1311 26.2 µM -0.0999270883943646 0.467969513271028 no 1789 0.460201105276055 2558 2862016
SGTC_2119 5528445 120.635 µM -0.100031482183271 0.467930600998668 no 1790 0.460159665809795 2684 791935
SGTC_1731 st035964 63 µM -0.100581170889151 0.46772571229516 no 1791 0.459941472174586 2652 6739575
SGTC_555 4296-0685 37 µM -0.101273377687585 0.467467714153809 no 1792 0.459666724523951 2568 2908540 YHR072W ERG7
SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM -0.103480020457754 0.466645349756326 no 1793 0.45879100286217 2638 688798
SGTC_317 4495-0002 170 µM -0.103749459317186 0.466544945848232 no 1794 0.458684087773608 2622 15991618
SGTC_1064 honokiol 6.76 µM -0.104399175788208 0.466302843761354 no 1795 0.458426288367474 2668 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis.
SGTC_2457 5731572 11.68 µM -0.10590501394299 0.465741775461147 no 1796 0.457828857946082 2691 2865357
SGTC_775 4577-0580 57.3 µM -0.106113262751764 0.465664188256564 no 1797 0.457746244202229 2799 2006902
SGTC_780 0109-0199 192 µM -0.106197374864364 0.465632850998485 no 1798 0.457712876862357 2754 610414
SGTC_1889 st059080 5.18 µM -0.106454366659479 0.465537106083265 no 1799 0.457610929866736 2575 176925 Isolated from Daphnopsis sellowiana.
SGTC_2984 9022109 38.96 µM -0.107237423955339 0.46524538242159 no 1800 0.45730031328763 2559 6459207
SGTC_2654 protoveratrine a 100 µM -0.107843238458942 0.465019702387444 no 1801 0.457060021773178 2598 5702278 A heart drug and vasodilator.
SGTC_1446 4239-0190 62 µM -0.108311530985824 0.464845260203802 no 1802 0.456874288012272 2611 1340085
SGTC_720 r052-1644 49.9 µM -0.108660197788425 0.464715383810328 no 1803 0.456736006214458 2684 1422863 YOR257W CDC31
SGTC_3346 9158254 43.5805 µM -0.108671196243561 0.464711287009666 no 1804 0.456731644295141 2689 17639500
SGTC_2762 leflunomide 42.06 µM -0.109710696633247 0.464324101768271 no 1805 0.456319408471493 2615 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1
SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM -0.110116783168814 0.464172854883528 no 1806 0.456158379028568 2832 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W
SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM -0.11237790533347 0.463330795459797 no 1807 0.455261886667052 2705 616764
SGTC_1529 apigenin 74 µM -0.11280860173452 0.463170419290327 no 1808 0.455091149340275 2731 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_719 2810-4230 27.3 µM -0.113739432904429 0.462823831030739 no 1809 0.454722176201128 2604 721079
SGTC_2231 micatex 6.853 µM -0.11403209376254 0.462714866693866 no 1810 0.454606176114547 2632 20737 An antifungal of unknown mechanism.
SGTC_1617 st002906 78 µM -0.115299454675535 0.462243031609464 no 1811 0.454103885293387 2606 5150859
SGTC_447 ml7 120 µM -0.115581732094441 0.462137947690841 no 1812 0.453992020768426 2652 4216 Selective myosin light chain kinase inhibitor.
SGTC_1499 4480-0877 67.3 µM -0.115669202694201 0.462105385390535 no 1813 0.453957357534775 2612 2861909
SGTC_3058 9093861 49.47 µM -0.115841234836529 0.462041344473184 no 1814 0.453889184904847 2721 17217477
SGTC_1395 3486-0190 4.35 µM -0.116615779283294 0.461753023725892 no 1815 0.453582266492294 2641 6748079
SGTC_2091 4-phenylthiadiazole 200 µM -0.117095156263142 0.461574587823254 no 1816 0.453392324037012 2645 270010
SGTC_2001 4023502 57.655 µM -0.118522786201153 0.461043234802252 no 1817 0.452826720782607 2704 108941 YCR052W RSC6
SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM -0.11902270227308 0.460857186227818 no 1818 0.452628684907374 2672 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_2681 menadione 3.18 µM -0.119365950606319 0.460729448017602 no 1819 0.452492717934865 2654 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_822 1487-0950 154 µM -0.119415122668911 0.460711149203403 no 1820 0.452473240433072 2624 1958375
SGTC_1458 k015-0034 6.33 µM -0.120429809121886 0.460333564007555 no 1821 0.452071339486768 2654 3598957
SGTC_1923 st058458 19.1 µM -0.121587346804868 0.459902864693721 no 1822 0.451612917460424 2816 3534982
SGTC_258 haloperidol 50.781 µM -0.122326238611218 0.45962796068051 no 1823 0.451320326317027 2636 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_2519 cryptotanshinone 88.04 µM -0.122660305748698 0.459503677638803 no 1824 0.45118804892868 2664 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE)
SGTC_1780 st038448 24.544 µM -0.124101023516609 0.458967732702189 no 1825 0.450617643888235 2828 728868 YDL195W SEC31
SGTC_2761 levamisole 97.89 µM -0.124909926255339 0.458666854672442 no 1826 0.450297429953302 2677 26879 An alkaline phosphatase inhibitor.
SGTC_3026 9090633 49.47 µM -0.12512211161075 0.458587934496681 no 1827 0.450213439161359 2623 25236842
SGTC_2380 9035439 200 µM -0.125290387554231 0.458525347138644 no 1828 0.45014683091988 2757 6462575
SGTC_2828 7998861 71.43 µM -0.127035722610123 0.457876260545916 no 1829 0.449456062514486 2674 2988188
SGTC_2760 etidronate 98.04 µM -0.127318087754543 0.457771260028302 no 1830 0.449344322424131 2675 3305 A chelator and antioxidant.
SGTC_987 1497-1013 404 µM -0.127322003303842 0.457769804009859 no 1831 0.449342772955745 2626 1676435
SGTC_2062 5245942 200 µM -0.127383761249092 0.457746839054798 no 1832 0.449318334089997 2609 1376160
SGTC_129 0088-0017 176.636 µM -0.129280032719758 0.457041771460374 no 1833 0.448568035209227 2648 182446
SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM -0.129619834478284 0.456915441319253 no 1834 0.448433604995974 2628 1377
SGTC_1805 st050013 60.3 µM -0.130018136866352 0.456767367591499 no 1835 0.448276038673989 2711 4037144
SGTC_3013 9080133 71.4286 µM -0.130559310400963 0.456566189410328 no 1836 0.448061966360201 2791 17050193
SGTC_2959 9079155 11 µM -0.131313531672983 0.456285830525609 no 1837 0.447763643877087 2785 16189457
SGTC_2877 9040724 71.43 µM -0.133642320677938 0.455420311775291 no 1838 0.446842708640303 2773 6463895
SGTC_2255 7941087 197.44 µM -0.13384668694037 0.455344366957399 no 1839 0.446761904237268 2746 935561
SGTC_2976 9009005 19.48 µM -0.13385985035857 0.45533947533801 no 1840 0.44675669962737 2744 2993148
SGTC_501 nsc-95397 161 µM -0.134044967051838 0.455270685381809 no 1841 0.44668350835074 2808 262093
SGTC_1125 tnp00248 1.32998 µM -0.134725248345144 0.455017902209705 no 1842 0.446414554945861 2799 24207736
SGTC_2026 5148700 152 µM -0.135074134281979 0.454888268053209 no 1843 0.446276630293497 2646 79838
SGTC_2326 6164455 177.58 µM -0.135469310033156 0.454741439978146 no 1844 0.446120413796464 2712 2888790
SGTC_1744 st037937 38.9 µM -0.135966737148008 0.454556629065789 no 1845 0.445923788315246 2774 1016152
SGTC_2256 7954252 200 µM -0.136269434862523 0.454444171490364 no 1846 0.445804142951869 2726 2972920
SGTC_1204 4049-0315 18.3 µM -0.139529145767813 0.453233364249513 no 1847 0.44451601310237 2917 588402
SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM -0.139978754032019 0.45306639282255 no 1848 0.444338388463212 2767 6708760
SGTC_1551 6-bromo-3'-methylflavone 63.5 µM -0.140328564901117 0.452936488982127 no 1849 0.444200198045563 2807 688751
SGTC_922 1866-0035 480 µM -0.140644388435258 0.45281921081746 no 1850 0.444075439921034 2664 3156169
SGTC_1005 4092-0690 4.4 µM -0.14127822605505 0.452583853475453 no 1851 0.443825075082857 2715 1529343
SGTC_1521 st012942 49.4 µM -0.141386011264302 0.452543832197846 no 1852 0.443782502326522 2903 24207259
SGTC_3183 9108214 49.47 µM -0.142017163797854 0.452309491266993 no 1853 0.443533224175109 2659 4974831
SGTC_440 fluspirilene 35.1 µM -0.142070820474469 0.4522895698185 no 1854 0.443512033120764 2916 3396 An atypical antipsychotic.
SGTC_1131 3454-3128 32.3 µM -0.143784103066417 0.451653532138534 no 1855 0.442835478170861 2849 710982
SGTC_3015 9080845 49.47 µM -0.143913824246559 0.451605379582488 no 1856 0.44278425957928 2770 5296973
SGTC_1979 st071809 45.3 µM -0.146056747976483 0.450810028960225 no 1857 0.441938295146243 2804 4976333
SGTC_233 rapamycin 362 pM -0.146952079935119 0.450477782936723 no 1858 0.44158492212533 2710 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C
SGTC_2520 obtusaquinone 4.71 µM -0.147154704635109 0.45040259635778 no 1859 0.441504955879823 2818 5967872
SGTC_1383 3049-0032 20.7 µM -0.147340060448014 0.450333819186933 no 1860 0.441431806923449 2810 712864
SGTC_107 0358-0022 2.6945 µM -0.147751181014038 0.45018127623841 no 1861 0.441269569129269 2740 521106 YGL093W | YPR107C SPC105 | YTH1
SGTC_726 3448-4391 34.2 µM -0.147949015581807 0.450107873949662 no 1862 0.441191502490546 2818 1356692
SGTC_2902 5787006 60.46 µM -0.149507951336442 0.449529524065503 no 1863 0.440576417812785 2692 591003
SGTC_1010 4112-3296 15.2 µM -0.150061556506471 0.44932416770363 no 1864 0.440358024972394 2816 704384
SGTC_503 tyrphostin 8 294 µM -0.150103790486636 0.449308501830394 no 1865 0.44034136474682 2725 92970 A tyrosine kinase inhibitor. YOR207C RET1
SGTC_3256 9138902 49.47 µM -0.150209739840042 0.449269202326906 no 1866 0.440299570900096 2642 17228773
SGTC_148 3253-0744 288.01 µM -0.150669127021211 0.449098808859712 no 1867 0.440118364115936 2648 6893655
SGTC_1701 st028638 40.4 µM -0.152485839927166 0.448425055566516 no 1868 0.439401878968896 2729 3490878
SGTC_534 k292-0788 63.4 µM -0.152512153942805 0.448415297735262 no 1869 0.439391502556348 2654 4146317
SGTC_1058 3448-5425 97.3 µM -0.152902007847744 0.448270734762586 no 1870 0.43923777624834 2654 7279705
SGTC_2056 5235370 200 µM -0.153124858219442 0.44818810198825 no 1871 0.439149906509556 2731 5511916
SGTC_3042 9091578 49.47 µM -0.15438918575237 0.4477193328153 no 1872 0.438651439974358 2653 25236497
SGTC_365 0121-0052 13.6 µM -0.154652146115115 0.447621845305065 no 1873 0.438547778923039 2800 3101739
SGTC_2649 anisomycin 9.56 µM -0.156150438752162 0.447066442597471 no 1874 0.437957220781987 2725 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_3227 9130768 49.47 µM -0.156297913395036 0.447011780755507 no 1875 0.437899100498425 2700 17720899
SGTC_2088 5278280 127.392 µM -0.156849549304488 0.446807324471123 no 1876 0.437681710703508 2764 791502
SGTC_1867 st057372 64 µM -0.157041028922116 0.446736358479571 no 1877 0.43760625642267 2698 688837
SGTC_2517 totarol 10 µM -0.157306413729798 0.446638004638304 no 1878 0.43750168288311 2747 460178 An antibacterial membrane disruptor. YGL001C ERG26
SGTC_871 0574-0004 149 µM -0.158152028182501 0.446324634733088 no 1879 0.437168501941624 2694 9551173
SGTC_2872 9044037 25.97 µM -0.160047178864756 0.445622447114761 no 1880 0.436421954916547 2668 6465195
SGTC_2165 5727197 32.143 µM -0.160386287189826 0.445496819269089 no 1881 0.436288395511476 3097 1361712
SGTC_2842 9000675 19.48 µM -0.161550479162264 0.445065568336322 no 1882 0.435829928407961 2755 2989072
SGTC_1659 st012954 42.1 µM -0.161876015233848 0.444944991813024 no 1883 0.435701745379831 2818 24207262
SGTC_229 benomyl 22.8748 µM -0.163624109767536 0.44429759593013 no 1884 0.435013531826379 2767 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C
SGTC_2262 9014885 67.46 µM -0.164700264990466 0.443899122353052 no 1885 0.43458995419874 2718 6457424
SGTC_1356 1502-0781 85.8 µM -0.164758343296429 0.443877619006669 no 1886 0.434567096550016 2691 567702
SGTC_2336 9001819 198.65 µM -0.164827560527771 0.44385199171705 no 1887 0.434539855284244 2897 2989602
SGTC_2594 a-mangostin 100 µM -0.165069965968974 0.443762244320933 no 1888 0.434444456186738 2853 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis.
SGTC_1774 st048371 48.465 µM -0.167225348661078 0.442964369859621 no 1889 0.43359636994849 2707 4242727
SGTC_2441 5730946 39.09 µM -0.16817215547816 0.442613956058752 no 1890 0.433223922826812 2832 1774275
SGTC_2965 9082772 38.63 µM -0.169148125371785 0.442252795970218 no 1891 0.432840065842706 2808 16459634
SGTC_3307 9126885 69.2785 µM -0.170523150349061 0.441744046059571 no 1892 0.432299364816897 2709 24824909
SGTC_3023 9089636 49.47 µM -0.17107197294256 0.441541012207657 no 1893 0.43208358666711 2697 17249241
SGTC_743 1275-0778 158 µM -0.17126914218915 0.441468074294194 no 1894 0.432006071450147 2828 2849257 YMR203W TOM40
SGTC_2927 9011802 47.9 µM -0.171929596849578 0.441223769810345 no 1895 0.431746439057885 2824 43912568
SGTC_1479 0549-0158 134 µM -0.172048309992237 0.441179859773 no 1896 0.431699774666193 2754 5440202
SGTC_1278 0874-0585 172 µM -0.173126711559086 0.440781009967642 no 1897 0.431275914591419 2767 766306
SGTC_2060 5238662 140 µM -0.174379559102704 0.440317716286644 no 1898 0.430783588836076 2816 790130
SGTC_2164 5685496 200 µM -0.175947612805712 0.439737976900924 no 1899 0.430167549587788 2738 759046
SGTC_914 3820-6779 408 µM -0.176126974553506 0.439671671650201 no 1900 0.430097094771192 2693 2893481
SGTC_511 blebbistatin 171 µM -0.176154630258081 0.439661448224923 no 1901 0.430086231573737 2855 3476986 A myosin inhibitor.
SGTC_1790 st045711 43.5 µM -0.176461179188186 0.439548129632729 no 1902 0.42996582229348 2834 585119
SGTC_2899 9053889 58.44 µM -0.177879820067824 0.439023780807902 no 1903 0.429408679673245 2742 6470052
SGTC_269 exalamide 29 µM -0.177892286719143 0.439019173438105 no 1904 0.429403784268649 2748 3316 A derivative of salicylamide.
SGTC_1112 tnp00069 1.16933 µM -0.177985469363343 0.438984735670756 no 1905 0.429367193652155 2842 145826
SGTC_1311 1190-0148 100 µM -0.178459002318805 0.438809737930171 no 1906 0.429181257864771 2834 1961333
SGTC_3016 9080866 49.47 µM -0.178752291245321 0.438701356750861 no 1907 0.42906610394166 2735 17066299
SGTC_2670 beta-carotene 100 µM -0.179548537064979 0.438407137472289 no 1908 0.428753504709208 2778 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.)
SGTC_1427 4048-4900 550 nM -0.179601728670806 0.438387483954251 no 1909 0.428732623734336 2849 24132586
SGTC_1374 2889-5571 141 µM -0.181463510238216 0.437699679050244 no 1910 0.428001886120472 2796 2853281
SGTC_2822 7994718 71.43 µM -0.182283132690789 0.43739694241216 no 1911 0.427680267544179 2680 1018011
SGTC_1366 1683-0113 21.9 µM -0.183334652239033 0.437008605702067 no 1912 0.42726772329842 2720 708623
SGTC_1331 1472-0049 76.2 µM -0.18495687905937 0.436409620234924 no 1913 0.426631428742623 2724 24051409
SGTC_153 4077-0274 519.67 µM -0.185238830999181 0.436305528100945 no 1914 0.426520856677015 2959 3121976
SGTC_656 4090-1979 187 µM -0.186896355108303 0.435693686205043 no 1915 0.425870948524475 2831 22330961
SGTC_1706 st031321 9.9705 µM -0.189553701389801 0.43471310165126 no 1916 0.424829435133898 2843 6103185
SGTC_1989 st071868 50.2 µM -0.189643254124456 0.434680062849923 no 1917 0.42479434516368 2883 16414057
SGTC_2627 acetyl isogambogic acid 100 µM -0.190321436813025 0.434429874893595 no 1918 0.424528628250387 2843 6857789 A caspase activator and apoptosis inducer.
SGTC_3118 9124250 49.47 µM -0.190377488044069 0.434409198242046 no 1919 0.424506668502844 2812 1504786
SGTC_3178 9107506 49.47 µM -0.190832061545537 0.43424151796204 no 1920 0.424328584389001 2866 8897194
SGTC_706 4262-0057 46.9 µM -0.192244821236504 0.433720463499213 no 1921 0.423775219180055 2744 883298
SGTC_1288 0973-0013 65.5 µM -0.192442549780999 0.433647546362978 no 1922 0.42369778265872 2845 4315430
SGTC_1364 1653-0028 37.6 µM -0.192630339787037 0.433578296391579 no 1923 0.423624241099832 2819 5718652
SGTC_2400 5203494 178.7 µM -0.193098463634298 0.433405678604643 no 1924 0.42344092792811 2704 6777674
SGTC_2350 9023895 38.85 µM -0.193243541540367 0.433352184596755 no 1925 0.423384120060568 2887 2997209
SGTC_850 0388-0143 75.9 µM -0.193653338893856 0.433201088222901 no 1926 0.423223665131352 2764 67273
SGTC_2278 7948257 134.34 µM -0.19437623896346 0.43293457157006 no 1927 0.422940646827643 2898 1247028
SGTC_2356 9061756 188.97 µM -0.196464505038536 0.432164847574179 no 1928 0.422123306061263 2826 20104043
SGTC_696 1560-0013 611 µM -0.196475190332156 0.432160909690082 no 1929 0.422119124730191 2950 1650269
SGTC_2870 9038528 12.99 µM -0.197274121499432 0.431866496248996 no 1930 0.421806514726319 2886 6463316
SGTC_1753 st043925 64 µM -0.197394458535596 0.431822154225612 no 1931 0.421759432880114 2844 670181
SGTC_23 0213-0011 39.996 µM -0.198294038132083 0.431490702648541 no 1932 0.421407507980215 2900 627608
SGTC_757 1066-0008 322 µM -0.198475066871943 0.431424008134719 no 1933 0.421336695231395 2913 6842497
SGTC_2693 st077581 40.7 µM -0.200391847162967 0.430717949247184 no 1934 0.420587067598661 2834 25238761
SGTC_938 3126-1755 342 µM -0.200728619250021 0.43059391979156 no 1935 0.420455390110595 2894 1777771
SGTC_2221 6807166 181.081 µM -0.200922996530562 0.430522335892356 no 1936 0.420379392874057 2823 674925
SGTC_1954 st077032 68.9 µM -0.200981284388599 0.430500870494368 no 1937 0.42035660418338 2833 698907
SGTC_2935 9038016 29.96 µM -0.201328602316615 0.430372969598328 no 1938 0.420220819504725 2859 6463195
SGTC_2040 5100729 123 µM -0.202073878570629 0.430098543994179 no 1939 0.419929484241939 2757 11840 YJR013W | YDR381W GPI14 | YRA1
SGTC_538 2922-0838 53.3 µM -0.202321575000512 0.430007344689729 no 1940 0.419832667161715 2876 777039
SGTC_2523 spermine 47.74 µM -0.202378907692514 0.429986235908083 no 1941 0.419810258229059 2878 1103 A DNA binding polyamine.
SGTC_924 2046-0044 21.3 µM -0.202630869534691 0.429893470833393 no 1942 0.419711780048605 2743 3623589
SGTC_2912 7964298 10.93 µM -0.203277253448987 0.429655508652155 no 1943 0.419459166739648 2848 2975850
SGTC_1335 1486-0900 202 µM -0.20489616541293 0.42905962871162 no 1944 0.41882662561035 2743 X1335
SGTC_2405 ticlatone 3.52 µM -0.20506851209497 0.428996201817687 no 1945 0.418759298658651 2669 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W
SGTC_758 0868-0029 16 µM -0.206376427242793 0.428514923751974 no 1946 0.418248441412472 2896 762687
SGTC_1768 st044301 37.178 µM -0.206539660571965 0.428454865664658 no 1947 0.418184693932823 2819 3931349
SGTC_1997 st073024 93.8 µM -0.207086616010491 0.428253637613174 no 1948 0.417971107208809 2862 686268
SGTC_3208 9114115 49.47 µM -0.207290689679125 0.428178562512536 no 1949 0.417891422401384 2848 650895
SGTC_504 lovastatin 124 µM -0.208031881544379 0.427905912993679 no 1950 0.417602037002642 2789 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1
SGTC_1552 6-methylflavone 10.6 µM -0.208078971119428 0.427888592122091 no 1951 0.417583653207524 2777 689013
SGTC_1947 st076332 61.6 µM -0.209953839815679 0.427199075873777 no 1952 0.416851850241859 2864 24208416
SGTC_960 1222-0186 7.7 µM -0.210719561019892 0.426917532135664 no 1953 0.416553054913041 2901 3126296
SGTC_1894 3',6'-dihydroxyflavone 78.7 µM -0.211244040586244 0.426724710656272 no 1954 0.416348423318126 2914 688662
SGTC_1656 st012921 11 µM -0.211355910235837 0.426683584776058 no 1955 0.416304779049222 2900 6732821
SGTC_2888 9058547 12.99 µM -0.212714547754137 0.426184181834941 no 1956 0.415774809486557 2794 16476514
SGTC_2379 9035213 200 µM -0.213436078956408 0.425919012134823 no 1957 0.415493420916653 2912 646551
SGTC_2739 tacrine 100.86 µM -0.213984877970392 0.425717345606026 no 1958 0.415279424846678 2878 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders.
SGTC_1434 4073-0095 163 µM -0.214358923368756 0.425579906713572 no 1959 0.415133585764681 2802 24133745
SGTC_2395 5646831 180.19 µM -0.21450933244828 0.425524643089597 no 1960 0.415074945049879 2942 6808628
SGTC_2305 7443522 69.23 µM -0.214979878535447 0.425351763498236 no 1961 0.414891503196305 2795 5415886
SGTC_12 0849-0099 9.267 µM -0.215128294859016 0.425297238014198 no 1962 0.414833647109936 2794 6071388
SGTC_3285 9112818 20.8695 µM -0.215854790536159 0.425030357221543 no 1963 0.414550469109683 2770 17017947 YPR165W RHO1
SGTC_288 1315-0019 35.1 µM -0.216428225199995 0.42481972819528 no 1964 0.414326983531954 2853 6811474
SGTC_2575 plumbagin 510 nM -0.216696852711079 0.424721065655974 no 1965 0.414222300451965 2746 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_399 oxolinic acid 75 µM -0.217684958412285 0.424358191039541 no 1966 0.413837292048837 2782 4628 A DNA gyrase inhibitor.
SGTC_506 n9-isopropylolomoucine 153 µM -0.218066595573061 0.42421805471928 no 1967 0.413688611973782 2935 6610355
SGTC_1389 3405-0187 19 µM -0.218296171787151 0.424133759455809 no 1968 0.413599178506321 2836 799890
SGTC_3273 9137859 49.47 µM -0.218324426920347 0.424123385041117 no 1969 0.413588171776138 2779 2377234
SGTC_487 nimodipine 119 µM -0.218828994843184 0.423938132099365 no 1970 0.413391629799095 2876 4497 L-type voltage-gated calcium channels inhibitor
SGTC_92 0063-0024 660.874 µM -0.218867624953887 0.423923949682882 no 1971 0.413376583286881 2733 3594437
SGTC_3145 9085516 49.47 µM -0.219098214401174 0.423839294569983 no 1972 0.413286770842017 2871 25236195
SGTC_1028 k015-0029 4.8 µM -0.219298411358118 0.423765800145231 no 1973 0.413208799668997 2783 4588309
SGTC_2734 clemastine 41.6 µM -0.219635141009896 0.423642189103351 no 1974 0.413077660513183 2774 26987 Clemastine is a selective histamine H1 antagonist.
SGTC_1279 0874-0590 65.2 µM -0.219890108508111 0.423548597359988 no 1975 0.412978370028983 2856 3523074
SGTC_180 1486-1293 102.781 µM -0.221863305962561 0.422824435632712 no 1976 0.412210148122706 2874 4140536
SGTC_316 k060-0003 58.6 µM -0.222323589557021 0.422655549370725 no 1977 0.412030994884702 2936 6152314
SGTC_1556 plumbagin 1.48 µM -0.222543798902118 0.422574755659268 no 1978 0.411945290691502 2783 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_2956 9076196 2.52 µM -0.222697624835533 0.4225183196229 no 1979 0.411885425026478 2912 16423868
SGTC_1614 st002383 48.6 µM -0.22354417709446 0.422207762942462 no 1980 0.411556002268297 2814 1947235
SGTC_2663 amphotericin b 100 µM -0.223558103462073 0.422202654475007 no 1981 0.411550583557622 2815 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_2992 9074591 71.4286 µM -0.223651483722686 0.422168401084144 no 1982 0.411514249995335 2890 17741321
SGTC_1439 4092-1168 46 µM -0.22429329707113 0.42193298950215 no 1983 0.411264545759317 2844 2886240
SGTC_941 3237-0776 460 µM -0.224790711187512 0.421750561489381 no 1984 0.411071046281759 2982 760008
SGTC_2047 4141938 200 µM -0.224796257871815 0.421748527322055 no 1985 0.411068888683388 2822 3807862
SGTC_895 0964-0006 13.7 µM -0.225406034346605 0.421524913244202 no 1986 0.410831708849935 2898 6738897
SGTC_589 1227-0070 34.1 µM -0.22681262103791 0.421009193666688 no 1987 0.410284724639224 2934 2841384
SGTC_1139 k015-0024 46.9 µM -0.226927359054012 0.42096713138227 no 1988 0.410240113754617 2883 2766652
SGTC_1553 gossypol 38.6 µM -0.227994988771251 0.420575787896785 no 1989 0.409825068159628 2779 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_3008 9078912 71.4286 µM -0.228531789985075 0.420379051122872 no 1990 0.409616422539607 2842 16648731
SGTC_168 3970-0862 530.542 µM -0.231631311897689 0.4192434718269 no 1991 0.408412192723893 2905 3135186
SGTC_2818 7996756 12.99 µM -0.232114796782042 0.419066396687525 no 1992 0.408224426264686 2769 2241621
SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM -0.232530650860453 0.418914104275469 no 1993 0.408062941797173 2916 5379071
SGTC_1238 0333-0287 48.8 µM -0.234981369126894 0.418016859580155 no 1994 0.407111596842951 2815 7226
SGTC_3218 9131285 49.47 µM -0.235374494571007 0.417872970038624 no 1995 0.406959040210408 2972 17156417
SGTC_380 3970-0968 6 µM -0.23721573287228 0.417199197080933 no 1996 0.406244715770251 2844 2891601
SGTC_2780 5215298 71.43 µM -0.237619795126351 0.417051369144433 no 1997 0.406087997956521 2966 2834131
SGTC_1360 1598-0022 39.8 µM -0.237876517075896 0.416957452391085 no 1998 0.405988434722296 2942 761525
SGTC_2430 5571206 200 µM -0.238468309524949 0.416740974645886 no 1999 0.405758945886075 2986 1731771
SGTC_2376 9072922 81.32 µM -0.239023401488972 0.416537944886225 no 2000 0.405543718417141 2961 17087968
SGTC_1000 4048-0884 8.67 µM -0.240006408318005 0.416178456163264 no 2001 0.405162644333581 2960 13040088
SGTC_1261 0712-0010 12.7 µM -0.240481839548253 0.416004614587288 no 2002 0.404978370093411 2979 2840123
SGTC_2159 5658611 73.75 µM -0.242071161196868 0.415423598110469 no 2003 0.404362511881884 2885 793844
SGTC_2004 4023728 41.89 µM -0.242483615794647 0.415272845129376 no 2004 0.404202725401346 2985 360084 YDR527W RBA50
SGTC_1193 1488-0126 41.5 µM -0.242630249670735 0.415219253158286 no 2005 0.404145922728926 2858 1384710
SGTC_2757 clomiphene 4.22 µM -0.243720798482077 0.414820727281462 no 2006 0.403723532078571 3054 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined.
SGTC_1789 tunicamycin 25 nM -0.24502161415904 0.41434547696148 no 2007 0.403219847846644 2962 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_1992 st073643 23.3 µM -0.245842515103749 0.414045626978946 no 2008 0.402902072256781 2805 3161292
SGTC_2813 7971799 71.43 µM -0.246375842732307 0.413850845561166 no 2009 0.402695652342115 2945 2234054
SGTC_2650 prasterone 100 µM -0.246698274378905 0.413733097652827 no 2010 0.402570871071765 2854 16759247 A steroid and weak partial agonist of the androgen receptor.
SGTC_741 4582-0002 126 µM -0.247435603576658 0.413463863636405 no 2011 0.402285561480885 2829 2912688
SGTC_187 1488-2104 32.728 µM -0.249563152111163 0.412687222793634 no 2012 0.401462598686324 2911 2852859
SGTC_422 cantharidin 155 µM -0.250332023587794 0.412406637651923 no 2013 0.401165296712132 2806 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_1983 st071813 46.9 µM -0.250601154089826 0.412308434120605 no 2014 0.401061244677446 2906 11838595
SGTC_457 grayanotoxin iii 135 µM -0.251306303214266 0.412051156991965 no 2015 0.400788651125551 2881 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity.
SGTC_1850 st056238 17 µM -0.251428313189839 0.412006644884483 no 2016 0.400741489925921 2809 5393177
SGTC_2998 9066762 71.4286 µM -0.25271577884219 0.411537016255097 no 2017 0.400243926917674 3020 4945196
SGTC_1905 st060207 84.5 µM -0.25432635853195 0.410949703843954 no 2018 0.39962171897587 2810 1948547
SGTC_3144 9087057 49.47 µM -0.255325618896234 0.410585414772348 no 2019 0.399235807249469 2879 17249618
SGTC_2925 9010536 32.5 µM -0.255667871685846 0.410460661251439 no 2020 0.399103652737435 2917 2994177
SGTC_204 PMA1.184 62.41 µM -0.255903618809881 0.4103747350544 no 2021 0.399012630120524 2840 2252213 YGL008C PMA1
SGTC_1487 3970-0795 2.82 µM -0.25653881770599 0.410143236260369 no 2022 0.398767405412253 2943 3765103
SGTC_2185 6113692 200 µM -0.256925275650015 0.410002406639146 no 2023 0.398618229110631 2992 874150
SGTC_259 usnic acid 108.925 µM -0.257448750258207 0.409811665117975 no 2024 0.398416186745957 3057 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_102 gallobenzophenone 83.616 µM -0.258791525550969 0.409322487873593 no 2025 0.397898048412806 3041 70837
SGTC_2848 9016370 25.97 µM -0.25910779249493 0.409207291346754 no 2026 0.397776036264469 2944 7894410
SGTC_571 k831-0106 44.2 µM -0.261495063657763 0.408338009429883 no 2027 0.396855377880887 2935 4783639
SGTC_3306 9127676 59.7925 µM -0.261531974715732 0.408324572459617 no 2028 0.396841147516958 2950 41905287
SGTC_875 0709-0210 25.7 µM -0.262729080050244 0.407888841015353 no 2029 0.396379700655165 2924 6251364
SGTC_784 4579-0127 173 µM -0.262900728661937 0.407826372381249 no 2030 0.396313547336338 3064 1948547
SGTC_1468 k284-1086 134 µM -0.26423308958809 0.407341561765226 no 2031 0.395800157526347 2908 15996457
SGTC_3110 9122132 49.47 µM -0.264868263798958 0.407110488709476 no 2032 0.39555547361251 3036 918317
SGTC_1809 st050081 57.6 µM -0.265353430285701 0.406934009451269 no 2033 0.39536860389416 3036 5036894
SGTC_1686 st019653 115.5 µM -0.265476967204147 0.406889075927013 no 2034 0.395321025493123 3010 97252
SGTC_703 3875-0075 71.8 µM -0.265702061968649 0.406807206378576 no 2035 0.395234337615102 2894 2850814
SGTC_478 N-arachidonylglycine 10 µM -0.265967644744494 0.406710616113351 no 2036 0.395132063772732 2938 5283389
SGTC_1970 st070122 35.8 µM -0.266840854069244 0.406393077117564 no 2037 0.394795848674425 3053 102928
SGTC_679 0422-0091 41.4 µM -0.268931582311139 0.405633042836424 no 2038 0.393991166399357 2869 627384 YHR062C RPP1
SGTC_3138 9097216 49.47 µM -0.269038492615649 0.40559418768382 no 2039 0.393950030747039 2823 25237486
SGTC_1841 st054148 70 µM -0.270438021842766 0.405085633008327 no 2040 0.393411646122559 2970 675442
SGTC_1259 0671-0132 43 µM -0.270622907909775 0.405018461899505 no 2041 0.393340537551377 2916 X1259
SGTC_3177 9107506 49.47 µM -0.270851012732346 0.404935592805128 no 2042 0.393252811624655 2996 8897194
SGTC_513 4245-1575 41.7 µM -0.271635452236188 0.404650643264689 no 2043 0.392951168548201 3003 719745
SGTC_2143 5623677 140.463 µM -0.272226084047583 0.40443612819308 no 2044 0.392724093377142 2882 5375313
SGTC_55 0767-0285 6.563 µM -0.273107909686663 0.404115906184942 no 2045 0.392385133365874 3003 3116166
SGTC_1864 st057645 30.4 µM -0.274727794533458 0.403527836363832 no 2046 0.391762687778744 2936 688666
SGTC_929 2805-0021 398 µM -0.275257561256995 0.403335561412329 no 2047 0.391559183356633 2965 3098024
SGTC_2923 7992654 58.14 µM -0.275297915465485 0.403320916105084 no 2048 0.391543682919292 2930 2985126
SGTC_2449 5812982 45.77 µM -0.27560813821931 0.403208334916132 no 2049 0.391424529145191 2948 776185
SGTC_3140 9094243 49.47 µM -0.278296047909918 0.402233217608737 no 2050 0.390392554825452 2899 19291112
SGTC_1707 st032323 6.317 µM -0.278417049131697 0.402189335160149 no 2051 0.390346116693777 2915 3132057 YMR211W DML1
SGTC_1309 pyrazolanthrone 13.4 µM -0.279570830278477 0.401770965497579 no 2052 0.389903394536845 2991 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14
SGTC_916 4466-0038 42 nM -0.279968859378338 0.401626663258958 no 2053 0.389750698234692 3094 5722064 YGL116W CDC20
SGTC_2617 dihydrotanshinone i 20.83 µM -0.279975410419118 0.401624288344124 no 2054 0.389748185194622 2907 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12
SGTC_1591 genipin 88.4 µM -0.280584114968366 0.401403633706004 no 2055 0.389514700602322 3038 442424 A DNA cross-linking agent.
SGTC_1200 1643-0193 18.4 µM -0.282463526320222 0.400722548112632 no 2056 0.38879405506022 2968 5403974
SGTC_2478 5763493 32.33 µM -0.283529292371663 0.400336455825597 no 2057 0.388385565214665 2893 1365576 YLR208W SEC13
SGTC_783 0848-0141 92.7 µM -0.284142743870666 0.40011426648116 no 2058 0.388150495714787 2877 6755076 YHR007C | YLR033W ERG11 | RSC58
SGTC_690 glyoxal 20.3 µM -0.284565709610226 0.399961089038168 no 2059 0.38798844262786 2930 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins.
SGTC_262 fenpropimorph 62.5 µM -0.285174144466289 0.399740770779263 no 2060 0.387755363997717 2885 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_876 0720-0963 56.8 µM -0.28544539205009 0.399642560528828 no 2061 0.387651467765986 3092 765861
SGTC_1368 1852-0141 284 µM -0.286310025068529 0.399329546411106 no 2062 0.387320340243055 3020 2838987
SGTC_2135 5326629 150.42 µM -0.286475272567428 0.399269730933165 no 2063 0.387257064918578 2952 5020077
SGTC_1157 4092-0394 27.6 µM -0.286721732777797 0.399180522870926 no 2064 0.387162697801571 3094 3659885
SGTC_1349 flufenamic acid 69 µM -0.287274701248567 0.398980391083051 no 2065 0.386950996050023 2890 3371 A non-steroidal anti-inflammatory.
SGTC_2269 7935389 174.42 µM -0.287484056808966 0.398904627500688 no 2066 0.386870853889533 2886 97605
SGTC_2824 7998404 51.95 µM -0.287974724983876 0.39872707476155 no 2067 0.386683043020461 2894 837851
SGTC_452 diindolylmethane 8 µM -0.288177543857046 0.398653689028346 no 2068 0.386605418693799 3027 3071 Inhibits expression of several cancer promoting factors.
SGTC_790 1575-0012 79.1 µM -0.289662427153335 0.398116524618719 no 2069 0.386037251651879 3082 378741 YLR208W SEC13
SGTC_3194 9111903 49.47 µM -0.290280399051246 0.397893026834658 no 2070 0.385800866440537 3125 17087251
SGTC_2990 9074105 71.4286 µM -0.291814098118088 0.397338489004215 no 2071 0.385214382718173 2984 6502001
SGTC_2306 7482397 179.52 µM -0.291852323337438 0.397324670600002 no 2072 0.385199768810648 3083 891448
SGTC_2840 9008771 71.43 µM -0.292955165193594 0.396926049191882 no 2073 0.384778210934283 3041 2992978
SGTC_1217 1183-1422 255 µM -0.294786116074318 0.396264491240369 no 2074 0.384078636583138 3063 2849664
SGTC_1197 1601-0112 267 µM -0.295553665376466 0.395987249551729 no 2075 0.383785481569202 2919 7350313
SGTC_2364 9055074 200 µM -0.296123757185452 0.395781364288826 no 2076 0.383567785785813 3014 6470630
SGTC_237 nikkomycin 200 µM -0.296571751898116 0.395619594063628 no 2077 0.38339673989401 3066 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine.
SGTC_3271 9137798 49.47 µM -0.296654433705389 0.395589739750574 no 2078 0.383365174184278 3043 6498326
SGTC_332 4112-0506 40.9 µM -0.296965328881543 0.395477488836053 no 2079 0.38324648962497 2924 2790355
SGTC_2694 st077685 81.9 µM -0.296985764558848 0.395470110693024 no 2080 0.383238688667413 2885 2838096
SGTC_668 1682-0499 62.6 µM -0.297719992035987 0.395205048422779 no 2081 0.382958441774748 2966 682214
SGTC_3005 9076496 71.4286 µM -0.298780213492507 0.394822385171645 no 2082 0.382553874536303 3033 21368410
SGTC_3320 9137005 35.139 µM -0.298960966972689 0.394757156352148 no 2083 0.382484914043973 2975 4908713
SGTC_446 go6976 132 µM -0.29945908923876 0.394577413385192 no 2084 0.382294891313702 3059 3501 A protein kinase C inhibitor.
SGTC_801 0866-0028 10.1 µM -0.300881308932161 0.394064341751171 no 2085 0.38175250179615 2895 6849771
SGTC_1963 st076565 50.3 µM -0.302273154696577 0.393562405570195 no 2086 0.381221920594088 2952 4914280
SGTC_2639 lactacystin 53 µM -0.302715567663864 0.393402896815853 no 2087 0.381053316420251 3084 3870 A proteasome inhibitor.
SGTC_2815 7968870 71.43 µM -0.30300867288341 0.393297229726717 no 2088 0.38094162606165 2935 2977326 YHR190W ERG9
SGTC_1280 0880-0253 10.1 µM -0.304380157337879 0.39280290169515 no 2089 0.380419141611778 2944 6836607
SGTC_2333 9017922 200 µM -0.305236421913772 0.392494363417439 no 2090 0.380093047246101 3081 3163164
SGTC_1399 3562-5772 25 µM -0.306342785112051 0.39209580702839 no 2091 0.379671833128627 2900 23847490
SGTC_2724 maprotiline 69.64 µM -0.306616467941513 0.39199723294457 no 2092 0.379567658723973 3052 4011 A tricyclic antidepressant.
SGTC_855 0428-0020 25 µM -0.307330176644827 0.391740204568647 no 2093 0.37929603437608 2969 6812414
SGTC_956 1185-0240 191 µM -0.308394630492113 0.391356949928885 no 2094 0.37889103362507 2960 1416193
SGTC_2454 5-benzylidenerhodanine 10.36 µM -0.308895655229412 0.391176593373612 no 2095 0.378700450963217 3134 1273210
SGTC_326 k292-0812 17.5 µM -0.309448823822776 0.390977493494308 no 2096 0.378490067781274 3029 3579357
SGTC_509 pifithrin 175 µM -0.309530768142762 0.390948002013689 no 2097 0.378458905466914 3042 4817 A p53 inhibitor.
SGTC_1109 tnp00067 928.257 nM -0.309748542195481 0.390869628925033 no 2098 0.378376092787982 2971 676295
SGTC_2502 avocadyne acetate 18.59 µM -0.309968656802441 0.390790418015704 no 2099 0.378292395745631 2885 3952079
SGTC_1221 2958-7315 257 µM -0.310342010076735 0.390656072677227 no 2100 0.378150443829196 3027 4562705
SGTC_2345 9052315 157.45 µM -0.310581399764015 0.390569938907239 no 2101 0.378059434597884 3039 6469265
SGTC_857 0438-0306 1.35 µM -0.31105697700219 0.390398839448305 no 2102 0.377878653575304 3051 4686136
SGTC_476 mead acid 10 µM -0.311135773779278 0.390370492608929 no 2103 0.377848703163167 2933 5312531 An omega 9 fatty acid.
SGTC_2849 9019321 12.99 µM -0.312412676382763 0.389911213121753 no 2104 0.377363458897314 3084 16489627
SGTC_321 4534-3890 65.3 µM -0.31351548913552 0.389514674335073 no 2105 0.376944527404214 3064 699746
SGTC_631 k072-0230 41.5 µM -0.313709374885062 0.389444970640057 no 2106 0.376870889922957 3061 5773147
SGTC_2196 6573537 42.6665 µM -0.314159180412667 0.389283275151564 no 2107 0.376700071793115 3070 2903087
SGTC_2300 7976697 71.57 µM -0.314397100530433 0.389197755695824 no 2108 0.376609729016261 2946 2236109
SGTC_532 1548-0774 215 µM -0.315552855252557 0.388782400612837 no 2109 0.37617096327707 3174 5932993
SGTC_693 4161-2696 114 µM -0.316273331436094 0.388523540194127 no 2110 0.37589752572541 3061 805759
SGTC_2198 6589944 200 µM -0.320678483432183 0.386941890462649 no 2111 0.374227027279353 3008 5290268
SGTC_678 1218-2179 85.9 µM -0.320853316840563 0.386879155850692 no 2112 0.374160776339401 3031 6820081 YOR116C RPO31
SGTC_2803 7707263 71.43 µM -0.320924865336835 0.386853483307816 no 2113 0.374133665000458 2972 2199229
SGTC_150 3970-0969 77.2 µM -0.321193476595111 0.386757106469197 no 2114 0.374031887692995 3078 6615640
SGTC_996 3970-0799 1.8 µM -0.326306760383944 0.384923815132076 no 2115 0.372096136934898 3041 6615648 YGL040C HEM2
SGTC_2459 5811157 9.22 µM -0.326498394728879 0.384855157212017 no 2116 0.372023651818705 2961 2870684 YBR192W RIM2
SGTC_2940 9060638 45.86 µM -0.326702581307239 0.38478200610531 no 2117 0.371946423848365 3072 4027022
SGTC_1572 epiandrosterone 68.9 µM -0.32758704359174 0.38446518940371 no 2118 0.371611959783047 2941 441302 A steroid.
SGTC_2492 derrusnin 100 µM -0.328568113011071 0.38411385803683 no 2119 0.371241076577492 2911 1715307 Part of coumarin class of compounds.
SGTC_74 000s-0487 160.283 µM -0.32953977776661 0.383765988414093 no 2120 0.370873866528287 2979 677548
SGTC_2190 6049624 200 µM -0.329643048540427 0.383729021528141 no 2121 0.370834845502352 3074 2265554
SGTC_2397 5161689 200 µM -0.330233728856739 0.38351760149031 no 2122 0.370611681545287 3183 2259942
SGTC_432 NS 1619 61.3 µM -0.330897249036523 0.383280151504742 no 2123 0.370361049991707 3158 4552 A K+/calcium channel activator.
SGTC_2470 5664817 21.68 µM -0.331567240069127 0.383040430317448 no 2124 0.370108030031845 2966 2859561
SGTC_838 0109-0203 71.4 µM -0.333083212901023 0.382498184312895 no 2125 0.36953573537181 2976 759422
SGTC_652 0437-0092 114 µM -0.333757548586016 0.382257056153869 no 2126 0.369281259783629 3010 3091274
SGTC_130 0136-0219 337.655 µM -0.338200415536333 0.380669526367611 no 2127 0.367606081367701 2947 234244
SGTC_1834 st055981 52.8 µM -0.339412825899546 0.380236654129474 no 2128 0.367149378891422 3155 471719 YDL150W RPC53
SGTC_66 0109-0187 42.4 µM -0.340820713463748 0.379734177996129 no 2129 0.36661927799247 2946 759417
SGTC_1831 st055328 12 µM -0.341611599466578 0.379451999178758 no 2130 0.366321603360602 3141 1103068
SGTC_1340 1486-1359 257 µM -0.341909204772625 0.379345833724447 no 2131 0.366209611128846 3012 4309068
SGTC_264 promethazine 12.5 mM -0.342430714845118 0.379159816130115 no 2132 0.366013388494364 3082 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3
SGTC_386 1509-0011 3.07 µM -0.342664099601325 0.379076579106075 no 2133 0.365925586825543 3002 3107280
SGTC_1411 3909-8223 150 µM -0.343958855639566 0.378614904348677 no 2134 0.365438614356973 3114 X1411
SGTC_281 1672-3440 14.9 µM -0.344748461437347 0.378333437383525 no 2135 0.36514174102576 3109 6833000
SGTC_3195 9113082 49.47 µM -0.345667350719149 0.378005966630729 no 2136 0.364796361866857 3110 17018038
SGTC_1680 diphenhydramine 100 µM -0.346242621339434 0.377800998160715 no 2137 0.364580193062844 3051 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1
SGTC_2839 9003951 25.97 µM -0.346265322038981 0.377792910624453 no 2138 0.364571663728671 3120 2990634
SGTC_41 0478-0632 82.643 µM -0.347330579553134 0.377413453594509 no 2139 0.364171489964941 3086 3750424
SGTC_110 0850-0284 111.64 µM -0.347365559433193 0.377400995361525 no 2140 0.36415835196005 2931 3906265
SGTC_157 1348-1695 65.819 µM -0.348252733605912 0.377085067191011 no 2141 0.363825193856954 3028 5380510
SGTC_2346 9031566 143.75 µM -0.348989615932957 0.376822721399239 no 2142 0.363548552673519 3091 4771086
SGTC_1267 0828-0272 9.49 µM -0.349840447959738 0.376519877829754 no 2143 0.363229220858774 3158 745334
SGTC_817 1391-0715 46 µM -0.350183242937256 0.376397885486721 no 2144 0.363100590886339 3061 1353946
SGTC_1633 st005664 67.9 µM -0.352820057210358 0.375459921370328 no 2145 0.362111673040142 2978 2063822
SGTC_167 3672-0051 66.205 µM -0.352835352248638 0.375454482780227 no 2146 0.362105939424966 2959 3237971
SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM -0.355156563520537 0.37462939695421 no 2147 0.36123615175035 3152 5024745
SGTC_2204 7233102 200 µM -0.355544083715503 0.374491706795715 no 2148 0.361091012664046 3035 2172480
SGTC_2712 st079126 47.7 µM -0.356282712066798 0.374229308407918 no 2149 0.360814427395044 3015 3152970
SGTC_564 3555-0129 330 µM -0.3565100360126 0.374148563088613 no 2150 0.360729318772631 3061 563260
SGTC_3061 glucosamine 200 µM -0.357200091294066 0.373903489725799 no 2151 0.360471008777881 3126 91431 and experimental redox chemotherapeutic
SGTC_853 0419-0306 21 µM -0.357563110805095 0.373774583677566 no 2152 0.360335144390066 3020 762713
SGTC_776 4476-4378 112 µM -0.358954178161531 0.373280754831413 no 2153 0.359814684209879 3113 2892008
SGTC_2686 alizarin 95.37 µM -0.35944748479848 0.373105680932832 no 2154 0.359630178612406 3079 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1
SGTC_966 1300-0360 30.2 µM -0.360892772374474 0.372592901149782 no 2155 0.359089803405673 3034 70588
SGTC_898 1000-0849 28.3 µM -0.362166104557955 0.37214131716577 no 2156 0.358613953656913 3128 6751807
SGTC_3046 9092212 49.47 µM -0.362240980024919 0.372114768240444 no 2157 0.358585979193962 3096 25236637
SGTC_977 1348-1378 135 µM -0.363102733287144 0.371809256367378 no 2158 0.358264071450633 3019 X977
SGTC_1285 0929-0069 65.5 µM -0.36313695087865 0.371797127088183 no 2159 0.358251291554262 3074 1206237
SGTC_2765 myclobutanil 7.74 µM -0.363459412869271 0.371682828640433 no 2160 0.358130863327215 3139 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11
SGTC_2829 7992743 58.44 µM -0.364191967967054 0.371423212455922 no 2161 0.357857332196793 3186 16462845
SGTC_1929 genistein trimethyl ether 50.5 µM -0.364196708152534 0.371421532733188 no 2162 0.357855562480983 3229 136420
SGTC_247 mechlorethamine 29.705 µM -0.364377506035481 0.371357467381772 no 2163 0.357788065109512 3035 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links.
SGTC_359 0081-0058 15.9 µM -0.364461847162393 0.371327582498936 no 2164 0.357756579511795 3418 3494159
SGTC_1845 st056753 3.01 µM -0.367609564346347 0.370212797166387 no 2165 0.356582191081862 3002 5375839
SGTC_3080 9117754 49.47 µM -0.368697871933434 0.369827618617915 no 2166 0.356176467562747 3266 9550191
SGTC_2702 st077768 96.8 µM -0.369020040304431 0.369713620416691 no 2167 0.356056393673323 3137 6484119
SGTC_983 1491-0821 12.2 µM -0.370701209390682 0.369118930334581 no 2168 0.355430044726217 3164 46495113
SGTC_2573 2',4'-dihydroxychalcone 15.04 µM -0.371158314846249 0.368957289748556 no 2169 0.355259809504896 3101 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_1243 0416-0003 5.65 µM -0.371393369166779 0.368874179397482 no 2170 0.355172281812484 3063 2141977
SGTC_1421 4029-0249 71.4 µM -0.371989256315385 0.368663513495636 no 2171 0.354950424255834 3208 2894095
SGTC_2391 6285546 200 µM -0.373917714062005 0.367982010427407 no 2172 0.354232768468139 3026 846083
SGTC_946 3434-1334 87.4 µM -0.375327428219923 0.367484090236506 no 2173 0.353708484952622 3188 4047976
SGTC_3147 9097027 49.47 µM -0.37721868107605 0.366816437364046 no 2174 0.353005549262578 3071 25236841
SGTC_312 4092-0653 6.84 µM -0.377389474820526 0.366756163300054 no 2175 0.352942093758444 3145 1148278
SGTC_3248 9135562 49.47 µM -0.377712411701185 0.366642206055037 no 2176 0.352822123244687 3119 17650701
SGTC_2604 4'-hydroxychalcone 11.32 µM -0.378388911174577 0.366403522545188 no 2177 0.352570852262186 3208 5282362
SGTC_2014 4013930 200 µM -0.378880439038836 0.36623013338484 no 2178 0.352388325285449 3165 64556
SGTC_2487 5918373 44.05 µM -0.379264843186884 0.366094551732536 no 2179 0.352245601970441 3220 2876279
SGTC_2771 fluoxetine 41.05 µM -0.3798623970619 0.365883824088598 no 2180 0.352023780775238 3252 3386 A selective serotonin reuptake inhibitor.
SGTC_3335 9143315 29.6265 µM -0.380305555974935 0.365727570020851 no 2181 0.351859305875879 3092 4899691
SGTC_2386 9075165 157.42 µM -0.380721464756151 0.365580944379428 no 2182 0.351704969858708 3110 16452277
SGTC_862 0452-0056 10.2 µM -0.381235977770527 0.365399583703488 no 2183 0.351514077459478 3154 1575396 YLR359W | YHR072W ADE13 | ERG7
SGTC_518 1021-0119 62.6 µM -0.381566101731755 0.365283234164542 no 2184 0.351391616006566 3105 1097762
SGTC_1227 3909-8010 46.6 µM -0.382359073233239 0.365003808403278 no 2185 0.351097521543497 3077 15982272
SGTC_1338 1486-1223 76 µM -0.382449099034778 0.364972089813452 no 2186 0.35106413872548 3131 3444526
SGTC_1185 1319-0113 81.3 µM -0.382617067408261 0.36491291236144 no 2187 0.351001856791808 3181 4672763
SGTC_1008 4106-0037 6 µM -0.3838649683011 0.36447336141791 no 2188 0.350539266064188 3003 2905394
SGTC_915 methyl methanesulfonate (MMS) 110 mM -0.384464919291973 0.364262102702891 no 2189 0.35031694600048 3149 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks.
SGTC_2680 butyl paraben 22.24 µM -0.385243070853013 0.363988156253369 no 2190 0.350028667663786 3137 7184 An antifungal and steroid mimetic.
SGTC_682 0kpi-0099 17 µM -0.386838058307499 0.363426861963179 no 2191 0.349438050005649 3176 1714895 YML126C ERG13
SGTC_3071 9117417 49.47 µM -0.388538643869345 0.362828729326373 no 2192 0.348808731086108 3098 45595590 YGL055W OLE1
SGTC_1143 3454-2408 5.08 µM -0.38866368947719 0.362784761273317 no 2193 0.348762473079428 3163 X1143
SGTC_2728 chlorpromazine 9.18 µM -0.389070285446323 0.362641808077992 no 2194 0.348612076949167 3076 2726 A thorazine and dopamine antagonist.
SGTC_2399 5884133 200 µM -0.38950952393436 0.362487399762671 no 2195 0.348449633381831 3093 722445
SGTC_3262 9137218 49.47 µM -0.392168009573118 0.3615533234453 no 2196 0.347467039712029 3083 17650664
SGTC_1838 st055369 84.5 µM -0.393180616510784 0.36119775389594 no 2197 0.347093042522242 3117 676036
SGTC_2168 5727979 200 µM -0.395126836536383 0.360514689776244 no 2198 0.346374642121115 3115 695210
SGTC_1510 1123-0200 71.5 µM -0.39553064704768 0.360373020207232 no 2199 0.346225654266421 3307 5378812 YNL149C | YNL150W PGA2 | YNL150W
SGTC_3035 9091303 49.47 µM -0.395895583316289 0.360245005446619 no 2200 0.34609102972096 3154 25237002
SGTC_975 1335-0046 28.5 µM -0.39765512220874 0.359628002858489 no 2201 0.345442211180713 3128 16486740
SGTC_1545 lovastatin 49.4 µM -0.398544715366819 0.359316195853868 no 2202 0.345114352095166 3183 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12
SGTC_2532 xanthone 78.9 µM -0.398566243431492 0.359308651315796 no 2203 0.345106419377775 3207 7020 An insecticide.
SGTC_3121 9125696 49.47 µM -0.400153402103715 0.358752580788479 no 2204 0.344521766708846 3149 1235365
SGTC_260 nsc-65238 3.989 µM -0.400242691039088 0.358721306756652 no 2205 0.344488886865542 3211 3246252
SGTC_361 000s-0510 1.45 µM -0.400750292863545 0.358543533911975 no 2206 0.344301989416073 3179 660
SGTC_2539 epi(13)torulosol 80 µM -0.401471869799288 0.3582908752361 no 2207 0.344036372420641 3205 6708597
SGTC_2117 5521686 200 µM -0.402504451545521 0.357929426789873 no 2208 0.343656406455346 3076 803312
SGTC_1896 st058441 89 µM -0.404371139457343 0.357276328302723 no 2209 0.342969909845319 3147 688759
SGTC_387 norethindrone acetate 66.7 µM -0.404590713491796 0.357199533321063 no 2210 0.342889192901194 3139 541197
SGTC_744 1594-0068 283 µM -0.404914334475328 0.357086358955744 no 2211 0.342770240646988 3128 668392
SGTC_3172 9105863 49.47 µM -0.406007490686301 0.356704161375499 no 2212 0.342368548277032 3150 2348785
SGTC_1791 st048313 56.1 µM -0.407652747146482 0.356129205523589 no 2213 0.341764316685737 3221 1204976
SGTC_1549 4'-methoxyflavonol 74.6 µM -0.408334687417938 0.355890988572792 no 2214 0.341513988177188 3171 97141
SGTC_3254 9136651 49.47 µM -0.408833525420833 0.355716768949329 no 2215 0.341330917485487 3147 16454030
SGTC_1824 st053723 68.6 µM -0.409123886520536 0.355615373945332 no 2216 0.341224373810731 3170 675225
SGTC_752 1896-0090 130 µM -0.411071407976237 0.354935557735557 no 2217 0.340510087348181 3130 772567
SGTC_2560 caryophyllene 100 µM -0.413047481754453 0.354246246590845 no 2218 0.339785913088615 3118 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor.
SGTC_2214 7179297 48.276 µM -0.413301323525703 0.354157733853959 no 2219 0.339692930147623 3150 769744
SGTC_86 0417-1630 471.922 µM -0.41561154607865 0.353352539127399 no 2220 0.338847138240584 3223 3634867
SGTC_149 3970-0822 46.1 µM -0.41571249972955 0.353317368121884 no 2221 0.338810196742912 3268 3114250 YBL034C STU1
SGTC_2480 5767542 37.17 µM -0.416229738138657 0.353137188302645 no 2222 0.338620950435701 3149 2867358
SGTC_1057 3448-5381 134 µM -0.41906080728571 0.352151570506667 no 2223 0.337585846507943 3235 5497911
SGTC_952 1185-0122 232 µM -0.419110186641258 0.352134388200373 no 2224 0.337567803151141 3121 678600
SGTC_1562 morin hydrate 59.1 µM -0.419197302176275 0.35210407574606 no 2225 0.337535971797673 3301 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase.
SGTC_1344 1488-0097 29.1 µM -0.419914989873661 0.351854387112609 no 2226 0.337273778428492 3235 747966
SGTC_1675 st018485 24.5 µM -0.420234259188008 0.3517433315791 no 2227 0.337157164921173 3167 3323024
SGTC_127 0180-0333 59.125 µM -0.42055657753383 0.351631228293098 no 2228 0.337039453620978 3218 771601
SGTC_1860 st056228 74.6 µM -0.421168839403778 0.351418317316405 no 2229 0.336815898317272 3242 688679
SGTC_1277 0873-0036 22 µM -0.421304090984369 0.351371290544925 no 2230 0.336766521649987 3248 5965735
SGTC_1703 st026983 48.3 µM -0.421358061532959 0.351352525701267 no 2231 0.336746819258373 3284 1104023
SGTC_766 1391-0721 126 µM -0.422279424520041 0.351032235939273 no 2232 0.336410537292186 3268 1020919 YIL115C NUP159
SGTC_627 1391-0720 175 µM -0.4224380618641 0.350977100138898 no 2233 0.336352650528378 3204 997839
SGTC_1786 berberine 21.6 µM -0.426400485465985 0.349600945649279 no 2234 0.334908023857046 3195 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_833 3852-0053 558 µM -0.428761555659594 0.348781880458561 no 2235 0.334048379487867 3309 3123681
SGTC_2796 7949634 45.45 µM -0.429066454811653 0.348676160923421 no 2236 0.333937431787253 3133 2971588
SGTC_2511 berberine 10.47 µM -0.429896142168522 0.3483885378966 no 2237 0.333635595944699 3150 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_393 acivicin 6.25 µM -0.430149075706702 0.348300872183878 no 2238 0.333543601471457 3109 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1
SGTC_166 k072-0058 166.424 µM -0.431275702921503 0.347910486372767 no 2239 0.333133957456922 3316 5846229
SGTC_1372 2752-0194 270 µM -0.432545879504193 0.347470552774707 no 2240 0.332672357252705 3219 823334
SGTC_1477 0139-0234 16 µM -0.432896340530103 0.347349204533658 no 2241 0.332545039342608 3218 620880
SGTC_904 1141-0088 396 µM -0.433842132784925 0.347021799081303 no 2242 0.332201541809487 3197 1378119
SGTC_979 1426-2828 121 µM -0.435859711284966 0.346323754554024 no 2243 0.331469258864598 3298 747872
SGTC_3231 9132313 49.47 µM -0.436107970796573 0.346237897391634 no 2244 0.331379197152375 3214 4905967
SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM -0.437028248032115 0.345919701039646 no 2245 0.331045431018821 3248 66535 A nucleotide analog.
SGTC_925 2064-1272 59.6 µM -0.438106396915212 0.345547057147062 no 2246 0.330654578734479 3176 6815817
SGTC_626 0214-0009 33 µM -0.439293449255626 0.345136945684378 no 2247 0.330224460086368 3293 3437874
SGTC_965 1291-5240 308 µM -0.440096632954268 0.34485955904126 no 2248 0.329933560241056 3292 2834598
SGTC_2978 9011784 42.97 µM -0.44070428536956 0.34464975625259 no 2249 0.329713546895684 3241 2994934
SGTC_2763 lisinopril 49.32 µM -0.443168593433736 0.343799400436529 no 2250 0.328821896878804 3278 5362119 A lysine-analog of enalapril and an ACE inhibitor.
SGTC_1726 st035556 14.5795 µM -0.443170487999841 0.343798746984115 no 2251 0.328821211749923 3348 5919439
SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM -0.444519204109462 0.343333681518679 no 2252 0.328333623806343 3264 4213774
SGTC_1152 3909-8331 15.9 µM -0.445571427018884 0.342971017716509 no 2253 0.327953427001823 3208 16001939
SGTC_1241 0364-0022 50.8 µM -0.447040945519237 0.34246476904844 no 2254 0.327422748243042 3195 4563895
SGTC_820 1582-0060 59.9 µM -0.448081682462358 0.342106406549362 no 2255 0.3270471236559 3195 3848840
SGTC_2534 helenine 20.12 µM -0.448899606285283 0.341824866231134 no 2256 0.326752040051262 3180 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58
SGTC_2652 actinonin 100 µM -0.450847505433128 0.341154727663131 no 2257 0.32604973002227 3169 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase.
SGTC_192 3455-0609 60.9 µM -0.452232274138791 0.340678628033927 no 2258 0.325550830023547 3321 3769639
SGTC_2618 avocadyne 43.43 µM -0.452717962399027 0.340511702804297 no 2259 0.325375921770018 3208 3015189
SGTC_2235 salicylic acid 500 µM -0.453736871769643 0.340161617409347 no 2260 0.325009112513345 3268 338 A COX inhibitor and kinase inhibitor.
SGTC_1457 k015-0032 57.3 µM -0.455187681634339 0.339663373786903 no 2261 0.324487110928695 3255 4302660
SGTC_280 3448-3607 3.04 µM -0.455467131360085 0.339567436049386 no 2262 0.324386604434429 3301 626179
SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM -0.458327545669679 0.338586027421022 no 2263 0.323358568537195 3214 2333 A French combination drug.
SGTC_1509 1326-1131 80 µM -0.458861760425866 0.338402859411328 no 2264 0.323166720256918 3292 768313
SGTC_1561 5-methoxyflavone 52.9 µM -0.459121319557653 0.338313877295886 no 2265 0.323073523829131 3269 94525
SGTC_1632 st005650 90 µM -0.459305748250626 0.338250656899738 no 2266 0.323007310232327 3276 2759605
SGTC_289 k017-0060 526 µM -0.462900509973256 0.337019319440058 no 2267 0.321717840976955 3216 5512909
SGTC_1928 4'-methoxychalcone 40.3 µM -0.463929487041876 0.336667177666987 no 2268 0.321349132921891 3388 641818
SGTC_905 2-aminofluorene 215 µM -0.464134287466972 0.336597106896066 no 2269 0.321275768827547 3259 1539 An established DNA mutagen. YPR165W RHO1
SGTC_2367 9070478 135.38 µM -0.464733614564269 0.336392084689648 no 2270 0.321061116523414 3252 572802
SGTC_2591 skatole 100 µM -0.465449842806359 0.336147135880475 no 2271 0.320804673840291 3309 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite.
SGTC_1543 azetidyl-2-carboxylic acid 198 µM -0.466220581929456 0.335883622141977 no 2272 0.320528809236483 3255 16486 A toxic proline analog.
SGTC_1802 st050112 57.9 µM -0.466332599795099 0.335845330230026 no 2273 0.320488723807149 3263 4662563
SGTC_1452 4194-0072 190 µM -0.466370304703706 0.335832441660017 no 2274 0.320475231631768 3352 1343545
SGTC_844 0330-0132 15.3 µM -0.466380135030033 0.335829081417084 no 2275 0.320471714025662 3343 2828079
SGTC_2171 5739187 198.077 µM -0.4664195851551 0.335815596543671 no 2276 0.320457597667623 3143 2262761
SGTC_1431 4049-0260 9.09 µM -0.468185301188346 0.335212254760756 no 2277 0.319826041329988 3269 3854841
SGTC_2428 5615643 7.78 µM -0.468204661683941 0.335205641668599 no 2278 0.319819119412141 3292 2253075
SGTC_1210 3013-0140 750 nM -0.469780617417528 0.334667503528482 no 2279 0.319255881836746 3321 905973
SGTC_3331 9141060 1.957 µM -0.474064117756224 0.333206543741907 no 2280 0.317727092676543 3211 4906567 YPR165W RHO1
SGTC_3226 9131256 49.47 µM -0.475390240436081 0.332754758585311 no 2281 0.317254424719714 3272 17178073
SGTC_2883 9059145 45.46 µM -0.476722965348763 0.332300968710556 no 2282 0.316779703656225 3183 16476510
SGTC_3314 9135860 59.4275 µM -0.476810356833071 0.332271220682531 no 2283 0.316748585044549 3351 25252478
SGTC_236 1509-0011 5.31 µM -0.476852506838511 0.332256873214447 no 2284 0.316733576612601 3403 3107280
SGTC_2048 5246248 200 µM -0.478095448002583 0.331833898244581 no 2285 0.316291135899348 3349 677046
SGTC_3191 9110352 49.47 µM -0.478721498119436 0.331620933438886 no 2286 0.316068384901188 3317 17122424
SGTC_711 k292-0785 179 µM -0.47929164296205 0.331427033389151 no 2287 0.315865583283704 3256 4146315
SGTC_477 mead ethanolamide 10 µM -0.479358638323362 0.33140425196169 no 2288 0.31584175654192 3250 16061185
SGTC_1268 0828-0275 2.46 µM -0.480635206462654 0.330970280814713 no 2289 0.315387894396799 3326 745337
SGTC_1332 1480-0653 17.5 µM -0.481573741931473 0.330651369114933 no 2290 0.315054391574012 3339 5749438
SGTC_3317 9138495 8.753 µM -0.481718904769863 0.330602054161688 no 2291 0.315002822300971 3316 17020139
SGTC_2880 9042983 58.44 µM -0.482444490670268 0.330355601050839 no 2292 0.314745111112003 3350 6464714
SGTC_215 1287-0124 461.5 µM -0.482852357578567 0.330217096929395 no 2293 0.314600285893335 3284 5560863
SGTC_2013 4024628 200 µM -0.4830981075153 0.330133655986984 no 2294 0.314513038871324 3376 5230760
SGTC_2526 patulin 37.61 µM -0.483254180241503 0.330080668069102 no 2295 0.314457634750991 3366 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.
SGTC_84 0443-0269 128.823 µM -0.485067854045765 0.329465161723369 no 2296 0.313814106962241 3346 6150058
SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM -0.485721080834601 0.329243589211528 no 2297 0.313582467544054 3411 5393153
SGTC_1883 5-benzylidenerhodanine 20 µM -0.486610832544686 0.328941884643613 no 2298 0.313267072734005 3338 1273210
SGTC_1674 st016616 23.6 µM -0.487168303227123 0.32875290950731 no 2299 0.313069532822864 3196 625830
SGTC_2177 5811945 192 µM -0.487685040887674 0.328577781417176 no 2300 0.312886474574856 3369 5343475
SGTC_2503 beta-caryophyllene alcohol 24.72 µM -0.488210605321496 0.328399700452261 no 2301 0.312700336689888 3362 61125 An anti-inflammatory.
SGTC_2555 cholic acid 100 µM -0.489802542391683 0.327860530377671 no 2302 0.312136815741284 3411 6708657 Influences liver metabolism.
SGTC_1415 3966-0071 78.1 µM -0.491985160385814 0.327121886752962 no 2303 0.311364917075502 3330 2893185
SGTC_2801 7907800 81.82 µM -0.492338542853299 0.327002358296013 no 2304 0.311240018655562 3333 6620925
SGTC_2908 7930301 100 µM -0.493247248233283 0.326695078340889 no 2305 0.310918948404769 3253 2223178
SGTC_1293 1000-1278 195 µM -0.494021921143321 0.326433214431262 no 2306 0.310645349061618 3393 678847
SGTC_1233 0325-0408 14.2 µM -0.49696605377476 0.325438785614433 no 2307 0.309606494939783 3373 12874
SGTC_1074 carmofur 3.8 µM -0.497318317384349 0.325319885852291 no 2308 0.309482298305153 3344 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_38 0929-0051 58.268 µM -0.497364206835952 0.325304398064902 no 2309 0.309466120785879 3337 1379719
SGTC_305 1682-2595 20.8 µM -0.49907859178356 0.324726005901244 no 2310 0.308862009301609 3342 226033
SGTC_2706 st078239 82.5 µM -0.499551598111216 0.324566499248689 no 2311 0.308695423176453 3376 15434492
SGTC_662 k832-1615 104 µM -0.499785878455591 0.324487507411441 no 2312 0.30861292753243 3340 5878478
SGTC_2695 st077686 51.995 µM -0.500640788949933 0.324199325940219 no 2313 0.308311975306945 3306 2876092
SGTC_1812 st052057 4.327 µM -0.503133949067211 0.323359509256466 no 2314 0.307435049740662 3297 3645418
SGTC_1305 1181-0477 144 µM -0.503382634143417 0.323275789369066 no 2315 0.307347639333327 3409 6252086
SGTC_2929 9013348 24.6 µM -0.503579861847583 0.323209398980217 no 2316 0.307278323475963 3322 2995952
SGTC_2265 7929201 200 µM -0.505144145494147 0.322683032564091 no 2317 0.306728798546828 3202 1265108
SGTC_1223 0764-0573 147 µM -0.505262535401471 0.322643209940158 no 2318 0.306687226427448 3340 1609797
SGTC_3267 9137951 49.47 µM -0.505584488801145 0.322534925278586 no 2319 0.306574186418916 3246 16643986
SGTC_737 1950-0117 57.9 µM -0.50589595100578 0.322430183511987 no 2320 0.306464847448595 3388 5393513
SGTC_1696 st025591 34.7925 µM -0.506769577602099 0.32213646645573 no 2321 0.30615825232606 3332 2787147
SGTC_2195 6536160 144.242 µM -0.507600968150032 0.321857052455146 no 2322 0.305866605767629 3255 3834386
SGTC_666 0272-0154 136 µM -0.508811597574743 0.321450363835688 no 2323 0.305442144695962 3323 6870312
SGTC_2017 5132927 60.65 µM -0.509174816766769 0.321328388749539 no 2324 0.305314846681636 3257 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis
SGTC_717 1532-0246 73.2 µM -0.509795112546231 0.321120127595308 no 2325 0.305097505057966 3342 9561992
SGTC_21 0849-0113 22.993 µM -0.509897055139818 0.321085906267964 no 2326 0.305061792592565 3318 1560156
SGTC_2212 7123476 200 µM -0.512033783637774 0.320368973374883 no 2327 0.304313682839916 3338 1085715
SGTC_1924 st058459 75.1 µM -0.515546386521594 0.319191852306833 no 2328 0.303085631928536 3372 688683
SGTC_186 3455-3465 67.277 µM -0.516577081320604 0.31884679737533 no 2329 0.302725708973893 3345 755278
SGTC_3092 9117248 49.47 µM -0.516582427658246 0.318845007942952 no 2330 0.302723842509544 3387 17141857
SGTC_1884 5633444 25 µM -0.516748281929284 0.318789498207676 no 2331 0.302665943548583 3408 5724239
SGTC_384 k007-0144 5.16 µM -0.517094925045347 0.318673493415918 no 2332 0.302544948060325 3343 6824886
SGTC_152 4469-0003 551.229 µM -0.51741510027234 0.318566361938941 no 2333 0.302433210431886 3422 697280
SGTC_2086 5274770 176.623 µM -0.517562837432077 0.318516933807814 no 2334 0.302381658030301 3353 689278
SGTC_2025 5147754 141 µM -0.517997798774598 0.318371428401115 no 2335 0.302229902573038 3341 315777 YLR208W SEC13
SGTC_3036 9090181 49.47 µM -0.51806773579212 0.318348035339978 no 2336 0.302205505148378 3376 25236586
SGTC_1413 3910-0535 34.4 µM -0.518217317998724 0.31829800438667 no 2337 0.302153326585084 3405 2876951
SGTC_1637 st007924 17.4 µM -0.518479743720139 0.318210238525659 no 2338 0.302061794740413 3342 683336
SGTC_701 4424-0219 185 µM -0.518785208125305 0.318108091626846 no 2339 0.301955267055897 3450 2911779
SGTC_3344 9148862 3.898 µM -0.51995016522755 0.317718658522396 no 2340 0.30154915481706 3445 4905352
SGTC_2561 acetosyringone 100 µM -0.520097759499964 0.317669333662652 no 2341 0.301497719959151 3260 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent.
SGTC_524 r073-0010 27.8 µM -0.521302292455888 0.317266909138172 no 2342 0.301078102138348 3299 2772106
SGTC_179 1273-0063 6.77 µM -0.521779826150854 0.317107428818786 no 2343 0.30091181872458 3282 3108139
SGTC_878 0828-0289 13.7 µM -0.521932633920447 0.317056403294253 no 2344 0.300858617829169 3352 745350 YLR208W SEC13
SGTC_3012 9080433 71.4286 µM -0.521993038622404 0.31703623393355 no 2345 0.300837588758156 3410 17688859
SGTC_274 sirtinol 40.1 µM -0.522143395709037 0.316986031488702 no 2346 0.300785246873888 3356 6836442 NAD-dependent acetyltransferase inhibitor.
SGTC_10 0279-0212 42.575 µM -0.522431679637613 0.316889786332409 no 2347 0.300684901779816 3368 39851 YBR002C RER2
SGTC_3223 9129970 49.47 µM -0.522917956492562 0.316727468240117 no 2348 0.30051567408766 3336 17248386
SGTC_91 0417-1751 58.384 µM -0.523097303420846 0.316667611552865 no 2349 0.300453270981507 3424 6795624
SGTC_1516 st013856 110 µM -0.523883855656136 0.316405157984828 no 2350 0.300179662170335 3376 5281404 A mutagen and neurotoxin.
SGTC_1202 1988-0068 29.6 µM -0.526047999332451 0.315683512653294 no 2351 0.299427428697818 3305 2850480
SGTC_3186 9110464 49.47 µM -0.526915764352619 0.315394348808613 no 2352 0.299126043003162 3439 17018021
SGTC_2515 chrysin 20.77 µM -0.527594935902779 0.315168108480911 no 2353 0.298890254295463 3381 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor.
SGTC_1758 st042942 75.2445 µM -0.528167480922243 0.314977440586464 no 2354 0.298691548852748 3401 669317
SGTC_1765 st044815 90.4 µM -0.529435295172849 0.314555410896185 no 2355 0.29825175961864 3372 645695
SGTC_1133 3473-0247 50 µM -0.532111383381179 0.313665390926883 no 2356 0.297324426857225 3308 711311
SGTC_2033 5192550 145 µM -0.533615672012595 0.313165566249317 no 2357 0.296803731561822 3327 182073
SGTC_3146 9095609 49.47 µM -0.535065976268014 0.312684003555269 no 2358 0.29630211801773 3363 17173999
SGTC_1546 5-methoxyflavanone 78.7 µM -0.53679390184597 0.312110675973874 no 2359 0.295704992219524 3432 147795
SGTC_3228 9131799 49.47 µM -0.536879733216094 0.312082208877491 no 2360 0.295675345569321 3371 17015818
SGTC_714 4296-0578 26.1 µM -0.537344794782154 0.311927984642674 no 2361 0.295514734380933 3357 1589775
SGTC_2854 9024559 71.43 µM -0.537655032846419 0.311825121479467 no 2362 0.295407614527057 3378 3163529
SGTC_13 0199-0087 65 µM -0.538322727367787 0.311603789120338 no 2363 0.295177131735729 3436 4589825
SGTC_3250 9135583 49.47 µM -0.538816077995265 0.311440293287229 no 2364 0.295006884264435 3443 7699353
SGTC_2894 9048625 32.47 µM -0.538968651807901 0.311389738025848 no 2365 0.294954242622839 3488 4092861
SGTC_2585 alliin 100 µM -0.540053124755386 0.31103050094917 no 2366 0.294580198106478 3521 87310 A garlic compound which reacts with lipids.
SGTC_1027 k015-0025 8.67 µM -0.540229494851584 0.310972094480938 no 2367 0.294519387163552 3397 3598955
SGTC_1829 berberine 14.4 µM -0.541478031668045 0.310558767037618 no 2368 0.294089067807266 3465 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_1622 st003707 19.4 µM -0.541479622153841 0.310558240660494 no 2369 0.294088519817513 3435 10140899
SGTC_2718 lomofungin 53.02 µM -0.542285051071037 0.310291730850321 no 2370 0.293811076079634 3460 5351222 A RNA synthesis inhibitor.
SGTC_1326 1431-2094 10.8 µM -0.542800072324154 0.310121366740624 no 2371 0.293633731713927 3338 616278
SGTC_686 1319-0111 510 µM -0.542913947400729 0.310083703453185 no 2372 0.293594526230206 3493 4562600
SGTC_2105 5350118 200 µM -0.543020190871641 0.310048566056008 no 2373 0.293557950379602 3407 2133313
SGTC_1086 cerivastatin 2.18 µM -0.546785539732546 0.308804392207017 no 2374 0.292263039335414 3419 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7
SGTC_1966 st070145 16.1 µM -0.547878162782147 0.308443769289448 no 2375 0.291887782042141 3338 3748532
SGTC_684 1140-0066 328 µM -0.549265817299651 0.30798603682436 no 2376 0.291411521053248 3437 6813534
SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM -0.550992279887775 0.307416961772885 no 2377 0.290819483396325 3358 6857784
SGTC_3163 9099914 49.47 µM -0.552461211136943 0.306933138652272 no 2378 0.29031620143247 3444 16268368
SGTC_2095 5432005 200 µM -0.553339007203511 0.306644178571652 no 2379 0.290015647721889 3368 783734
SGTC_2277 7947813 106.88 µM -0.553409884800772 0.30662085174496 no 2380 0.28999138589428 3522 1246798
SGTC_1657 st012939 43.4 µM -0.554453113852209 0.306277600862415 no 2381 0.289634392448818 3477 24207257
SGTC_2486 5283202 22.39 µM -0.554652591646034 0.306211986561056 no 2382 0.289566154560799 3366 1377751
SGTC_1653 st012112 65 µM -0.555813906349968 0.30583011837733 no 2383 0.289169038947641 3478 720429
SGTC_551 k048-0028 34.9 µM -0.555874682341828 0.305810139577574 no 2384 0.289148263438098 3482 6836383
SGTC_1776 st049249 45.9 µM -0.556197474371748 0.30570403832936 no 2385 0.289037932801002 3416 1822314
SGTC_1925 st057770 10.1 µM -0.556254655184202 0.305685244783704 no 2386 0.289018390407244 3344 5989122
SGTC_1583 clindamycin 39.6 µM -0.557929306742604 0.305135066330201 no 2387 0.288446329168514 3373 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis.
SGTC_496 calpeptin 138 µM -0.558119660838926 0.305072556541924 no 2388 0.288381337973068 3416 73364 A calpain inhibitor.
SGTC_673 1082-0474 110 µM -0.559336034245865 0.304673249802176 no 2389 0.287966203659905 3418 3098046
SGTC_1548 st061468 90.8 µM -0.559873098673438 0.30449701819481 no 2390 0.287782999549754 3425 390799
SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM -0.560806483708436 0.304190846444455 no 2391 0.287464733107178 3356 279621
SGTC_416 estradiol valerate 100 µM -0.560902571863972 0.304159335107887 no 2392 0.287431978336443 3468 13791 A steroid.
SGTC_1244 0416-0015 52.5 µM -0.561109761621219 0.304091393845581 no 2393 0.287361356981194 3390 96201
SGTC_807 1315-0151 48 µM -0.561468717968423 0.303973701590636 no 2394 0.287239024885386 3534 4011080
SGTC_3353 9151644 39.2805 µM -0.561971262659838 0.303808964659468 no 2395 0.287067799392451 3472 4909158
SGTC_1913 st060213 96.1 µM -0.56220136224056 0.303733550039298 no 2396 0.286989416701143 3511 688959
SGTC_451 chloral hydrate 100 µM -0.562462873572004 0.303647850432557 no 2397 0.286900346006658 3469 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1
SGTC_2819 7996655 46.38 µM -0.563137225328107 0.303426909141783 no 2398 0.286670722423306 3355 6456960
SGTC_3190 9110366 49.47 µM -0.563964503508877 0.303155961938467 no 2399 0.286389144937317 3407 17123768
SGTC_1936 st074407 74.3 µM -0.564456766980406 0.302994788925642 no 2400 0.286221657436943 3382 809813
SGTC_2134 5324836 1.464 µM -0.564775865695916 0.30289033263639 no 2401 0.286113112290847 3354 699272
SGTC_2636 apigenin dimethyl ether 100 µM -0.565406017540228 0.30268410113079 no 2402 0.285898816259653 3491 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_1077 5-fluorocytosine 377 nM -0.568004277544837 0.301834426802994 no 2403 0.285016031699412 3449 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_1501 4491-0275 38.4 µM -0.569203428845498 0.301442646203497 no 2404 0.28460904699989 3466 5104718
SGTC_2106 5357045 167.29 µM -0.569306274995385 0.301409055492937 no 2405 0.284574154562766 3439 668842
SGTC_248 streptozotocin 5.23457 mM -0.569558116583993 0.301326808309805 no 2406 0.284488721325056 3470 5300 DNA alkylating agent.
SGTC_1059 3448-6867 171 µM -0.57039288935321 0.301054258001522 no 2407 0.284205625635723 3477 3934407
SGTC_234 nsc-17383 10.7 µM -0.571032612665191 0.30084546587343 no 2408 0.283988768084706 3521 408974
SGTC_1034 k072-0165 12.7 µM -0.57113042555795 0.300813547576438 no 2409 0.283955617816345 3505 5835461
SGTC_3041 9091929 49.47 µM -0.573297800791957 0.300106682165354 no 2410 0.283221537104414 3556 25236887
SGTC_1352 1496-0991 99 µM -0.57486184066827 0.299597055053331 no 2411 0.282692369615834 3423 3000039
SGTC_427 1354-0053 47.3 µM -0.576292320930863 0.299131290689355 no 2412 0.28220880621431 3553 6813657
SGTC_2808 7946468 45.46 µM -0.576638385290142 0.29901866152949 no 2413 0.282091881521189 3441 2970879
SGTC_73 0327-0325 16.231 µM -0.577346604460379 0.298788226506554 no 2414 0.28185266839605 3518 53298
SGTC_2016 5121758 140 µM -0.577561705908068 0.298718254398432 no 2415 0.281780033564412 3483 2795203
SGTC_1508 1080-0625 72.9 µM -0.582308417456786 0.297176057624565 no 2416 0.280179478349119 3447 767111
SGTC_1878 temozolomide 1 mM -0.582600207397024 0.297081374531113 no 2417 0.28008123288214 3491 5394 DNA alkylating agent.
SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM -0.584883322047779 0.296341002014092 no 2418 0.279313086770733 3446 5711223 A potent inhibitor of glutathione S-transferases.
SGTC_2558 carylophyllene oxide 100 µM -0.585018383438905 0.296297230579033 no 2419 0.279267677915265 3558 6708694 An oxygenated terpenoid and antifungal agent.
SGTC_463 ikarugamyin 104 µM -0.586211384313241 0.295910725146499 no 2420 0.278866736152515 3507 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis.
SGTC_2732 terfenadine 20 µM -0.586620046166891 0.295778381161061 no 2421 0.278729458186806 3473 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.
SGTC_2476 5806916 10.51 µM -0.587137806423007 0.295610745029485 no 2422 0.278555579069178 3422 2870194
SGTC_2497 7-hydroxyflavone 100 µM -0.587956681526223 0.295345705625663 no 2423 0.278280684637365 3507 5281894
SGTC_1685 st024049 53.0905 µM -0.58828289521503 0.295240152855298 no 2424 0.278171212323604 3475 1941139
SGTC_2406 ethylparaben 405.7 µM -0.5883881191327 0.295206109318704 no 2425 0.278135905270072 3256 8434 A possible steroid mimic.
SGTC_1840 st055363 71 µM -0.590360380979012 0.29456834980379 no 2426 0.277474533137171 3456 676033
SGTC_1661 st013063 9.66 µM -0.59096980111486 0.294371413596112 no 2427 0.277270327657556 3512 721395
SGTC_2751 anetholtrithion 17.25 µM -0.59126145924772 0.294277184783882 no 2428 0.277172624394339 3480 2194 A chloretic substance that stimulates the liver to produce bile.
SGTC_998 3996-0085 177 µM -0.591331115008672 0.294254682484979 no 2429 0.277149292734567 3471 715391
SGTC_616 4092-0450 108 µM -0.591908225190867 0.294068277575931 no 2430 0.276956022817472 3506 787165
SGTC_2288 7946289 167.31 µM -0.592304665087221 0.293940260276613 no 2431 0.276823296282235 3548 1246052
SGTC_2731 amoxapine 43.43 µM -0.595831395867715 0.292802554000205 no 2432 0.275643933784474 3531 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine.
SGTC_1460 k062-0059 9.15 µM -0.595992022252432 0.292750785420125 no 2433 0.275590278113855 3442 1373085
SGTC_1300 1094-0077 113 µM -0.598293649879126 0.292009456754763 no 2434 0.274822006482817 3478 5532636
SGTC_1980 st071811 45.7 µM -0.598760313969918 0.29185925607437 no 2435 0.274666365199404 3574 4974850
SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM -0.599717803423853 0.291551190881636 no 2436 0.274347160552192 3568 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis.
SGTC_441 propafenone 146 µM -0.600297792415807 0.291364657461125 no 2437 0.27415389485665 3489 4932 Slows the influx of sodium ions into the cardiac muscle.
SGTC_2473 5854593 8.94 µM -0.600409635448553 0.291328693419563 no 2438 0.274116633917488 3472 2872951
SGTC_2332 7982454 138.89 µM -0.60042168384338 0.291324819283313 no 2439 0.274112620097408 3514 2981748
SGTC_2529 gangaleoidin 93.61 µM -0.601173780389137 0.291083031814231 no 2440 0.27386212303456 3514 4565183
SGTC_1610 st001799 48.1 µM -0.60133934361234 0.291029818375326 no 2441 0.273806994917659 3433 621897
SGTC_3207 9114163 49.47 µM -0.603580279333488 0.290310009882255 no 2442 0.273061363640436 3606 849233
SGTC_2630 antimycin a 100 µM -0.603892952880611 0.29020964267677 no 2443 0.272957407178193 3484 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain.
SGTC_1396 3511-0007 98.6 µM -0.60511383923569 0.289817897820445 no 2444 0.272551679722025 3492 X1396
SGTC_1902 st060212 70.5 µM -0.60515140283327 0.289805848752787 no 2445 0.272539201259576 3552 688944
SGTC_3113 9123498 49.47 µM -0.605258320064924 0.289771554789574 no 2446 0.272503685376624 3560 8897275
SGTC_2999 9069765 71.4286 µM -0.607281524764251 0.289122966155005 no 2447 0.271832048543467 3483 2097066
SGTC_1101 ebselen 5.29 µM -0.608999412810568 0.288572790854362 no 2448 0.27126241405336 3586 3194 A potent scavenger of hydrogen peroxide and hydroperoxides.
SGTC_2521 angolensin 13.4 µM -0.609851588589322 0.288300053969369 no 2449 0.270980062045888 3552 821428 A flavenoid.
SGTC_3350 9150499 3.57 µM -0.610531762040607 0.288082453299136 no 2450 0.270754804959646 3517 4910996 YPR165W RHO1
SGTC_670 4204-0025 119 µM -0.612311928182608 0.287513310833493 no 2451 0.270165699612726 3506 719039
SGTC_1127 asiatic acid 681.4 nM -0.614195825768972 0.286911583725041 no 2452 0.269542965707146 3501 470603 A kinase inhibitor which arrests cells at G2/M.
SGTC_949 1165-0505 146 µM -0.614259329313247 0.286891310748302 no 2453 0.269521986759793 3516 6244267
SGTC_2564 betulinic acid 100 µM -0.616441985022963 0.286194929052783 no 2454 0.268801425268108 3595 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14
SGTC_927 2425-1185 123 µM -0.621139792051935 0.284698811736278 no 2455 0.267253824828784 3519 730375
SGTC_251 melphalan 456.522 µM -0.62171948427427 0.284514455403034 no 2456 0.267063168711518 3582 460612 A DNA alkylator.
SGTC_484 loperamide 105 µM -0.623019437893304 0.284101245723278 no 2457 0.266635874235143 3504 3955 An opioid-receptor agonist.
SGTC_2638 epoxomicin 18 µM -0.625375853139702 0.28335295649827 no 2458 0.265862203206941 3534 9915668 A protesome inhibitor.
SGTC_223 busulfan 5 mM -0.626232111980363 0.283081282309949 no 2459 0.265581353731759 3533 2478 A DNA alkylator.
SGTC_1879 gemcitabine 100 µM -0.627798518421114 0.282584615933897 no 2460 0.265067968405982 3544 60750 A nucleoside analog which inhibits DNA replication.
SGTC_1518 st038567 90.8 µM -0.628647127359168 0.282315719363024 no 2461 0.26479004989175 3569 77966
SGTC_1371 2421-0008 32.7 µM -0.630104925110636 0.2818540782708 no 2462 0.264312968786381 3546 2827552
SGTC_733 4069-0007 56.1 µM -0.631118201569335 0.281533418253304 no 2463 0.263981620400563 3610 5717425 YNL287W SEC21
SGTC_489 paxilline 115 µM -0.631984713718245 0.281259342722396 no 2464 0.263698432976043 3558 105008 A toxic potassium channel blocker.
SGTC_3233 9132340 49.47 µM -0.632041399126085 0.281241417766067 no 2465 0.263679912849995 3496 17682950
SGTC_2146 5545642 200 µM -0.632064422751358 0.281234137434773 no 2466 0.263672390813587 3582 825326
SGTC_319 1348-1596 45.5 µM -0.633701103856578 0.280716833614221 no 2467 0.263137952209473 3623 5380505
SGTC_800 3448-7362 155 µM -0.633811331866686 0.280682010528423 no 2468 0.263101978476435 3643 15991913
SGTC_48 0382-0018 55 µM -0.634904554215391 0.280336754362638 no 2469 0.262745333317716 3689 762596
SGTC_529 4076-0302 30.3 µM -0.634974134766203 0.280314786734839 no 2470 0.262722642222483 3537 5816522
SGTC_1716 st033144 30.6155 µM -0.63732321790342 0.279573635410624 no 2471 0.261957165246654 3602 674617
SGTC_510 ag-490 170 µM -0.637740112567427 0.279442201843402 no 2472 0.261821434687759 3665 5328779
SGTC_2789 5281112 71.43 µM -0.638585922794975 0.279175637145923 no 2473 0.261546170739915 3568 765948
SGTC_181 1447-1644 8.07 µM -0.641501781533457 0.278257626773604 no 2474 0.260598361896766 3541 534600
SGTC_473 2-arachidonoylglycerol 10 µM -0.641680548590638 0.278201392809891 no 2475 0.260540310692324 3505 5282280 An endocannabinoid.
SGTC_777 1315-0167 517 µM -0.642876296272826 0.277825394312159 no 2476 0.260152185639022 3550 4221767
SGTC_2957 9076800 11.52 µM -0.643436160548633 0.277649432350702 no 2477 0.25997056304374 3506 16459615
SGTC_1053 3366-3204 134 µM -0.643631041347739 0.277588195268166 no 2478 0.259907358145426 3539 3632071 YPR165W RHO1
SGTC_395 anisomycin 6.25 µM -0.644804559894237 0.277219581985381 no 2479 0.259526923285938 3547 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_519 k048-0011 62.8 µM -0.645347324920471 0.277049175374732 no 2480 0.259351065353391 3570 6836379
SGTC_2035 5154463 94.595 µM -0.647563632792533 0.276353875506403 no 2481 0.25863361268774 3595 2769623
SGTC_2740 felodipine 17.08 µM -0.647623158119147 0.276335213037204 no 2482 0.258614357611184 3546 3333 L-type calcium channel blocker
SGTC_1476 4112-3294 3.34 µM -0.647691546597143 0.276313772542784 no 2483 0.258592236424921 3628 704369
SGTC_3342 9147791 14.508 µM -0.648217874941533 0.276148790484824 no 2484 0.258422021133939 3566 1838168
SGTC_4 0960-0234 25.671 µM -0.649344144294703 0.275795914380252 no 2485 0.258057979212619 3594 6821112
SGTC_3336 9143619 71.43 µM -0.649717186072237 0.275679083990453 no 2486 0.25793746028233 3626 45595730
SGTC_2495 cafestol 54.53 µM -0.651890478356204 0.274998929663707 no 2487 0.257235913898933 3620 16667697 An anti-infammatory.
SGTC_917 harmaline 728.087 nM -0.652941324925781 0.274670353117114 no 2488 0.256897053045573 3565 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7
SGTC_2738 aclarubicin 5.55 µM -0.654194554130111 0.274278749290662 no 2489 0.256493234849834 3504 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31
SGTC_396 dithiazanine 1.25 µM -0.655610299671647 0.273836694923715 no 2490 0.256037448403434 3564 10578 An antihelmenthic.
SGTC_1378 2093-0007 380 nM -0.657440649289978 0.273265706641555 no 2491 0.255448810744715 3602 3618014
SGTC_3201 9113999 49.47 µM -0.657516264396549 0.27324213075765 no 2492 0.255424508260125 3591 16649224
SGTC_950 1165-0508 94.1 µM -0.658490316793664 0.272938523017674 no 2493 0.255111558590664 3576 6148369
SGTC_2682 pyrogallin 40.03 µM -0.658553731629539 0.272918762700554 no 2494 0.255091191229495 3638 822798 An ATP competetive kinase inhibitor.
SGTC_2970 9090938 41.86 µM -0.661574185719964 0.271978399535714 no 2495 0.25412207796058 3627 17217104
SGTC_330 1488-0319 80.1 µM -0.662006234860422 0.271844020790806 no 2496 0.253983612951174 3599 6846614
SGTC_370 0180-0345 38.7 µM -0.662433340576157 0.271711212060249 no 2497 0.253846771153191 3555 3989527
SGTC_1314 1222-0010 41.1 µM -0.662621543259204 0.271652700597176 no 2498 0.253786484566038 3604 3526027
SGTC_172 1112-0046 2.638 µM -0.663592050685376 0.271351073327379 no 2499 0.253475723236879 3547 2802135 YIL048W NEO1
SGTC_1163 k060-0048 49.9 µM -0.663943134253087 0.271242000005625 no 2500 0.253363353794529 3633 6809982
SGTC_2315 7733312 200 µM -0.665321053389537 0.270814124604971 no 2501 0.25292258375788 3595 726316
SGTC_3038 9091290 49.47 µM -0.665801778916746 0.270664927649707 no 2502 0.252768903846805 3643 25236843
SGTC_1671 st016596 74.5 µM -0.666460315566055 0.270460612263002 no 2503 0.252558460528305 3651 2829167
SGTC_1880 MG-132 525 µM -0.668703879401315 0.269765110686267 no 2504 0.251842196179883 3575 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1
SGTC_1684 st024538 14.6195 µM -0.669045937755994 0.269659151825069 no 2505 0.251733087331533 3603 6732859
SGTC_2137 5261020 140 µM -0.669374064033756 0.269557528276493 no 2506 0.251628445961637 3616 763655
SGTC_2413 inermin 26.06 µM -0.66939209546139 0.269551944343591 no 2507 0.251622696301031 3694 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1
SGTC_3356 9151811 4.48 µM -0.669614251766752 0.269483152223675 no 2508 0.251551863270257 3604 1859254 YPR165W RHO1
SGTC_2120 5538279 151.968 µM -0.669758383218938 0.269438525705147 no 2509 0.251505913569796 3637 2058197
SGTC_1419 3993-2473 62.6 µM -0.671847869972478 0.268791987439292 no 2510 0.250840275095515 3659 704026
SGTC_1461 k072-0203 53.8 µM -0.672346787735755 0.268637725415881 no 2511 0.250681475130183 3576 5418714
SGTC_1118 chelidonine 707.474 nM -0.673028520540977 0.268427010161161 no 2512 0.250464573286911 3649 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor.
SGTC_367 0335-0881 7.1 µM -0.676204678406529 0.2674463955593 no 2513 0.24945535131663 3606 23828853
SGTC_2368 9071271 200 µM -0.676548925095794 0.267340220636006 no 2514 0.249346097125557 3624 27209959
SGTC_3288 9119690 36.221 µM -0.677450331334063 0.267062303527997 no 2515 0.24906013675663 3619 17595618 YKL019W RAM2
SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM -0.680111413302689 0.266242703834623 no 2516 0.248216959128301 3585 1241132 A phosphatase inhibitor.
SGTC_991 3996-0057 64.7 µM -0.680504629526708 0.266121703298753 no 2517 0.248092495739071 3638 715343
SGTC_2226 7298446 200 µM -0.680695496096015 0.266062979859321 no 2518 0.248032093399601 3635 3283010
SGTC_2673 kobusone 100 µM -0.682220546033748 0.265594007397835 no 2519 0.24754975239988 3704 6710676 An epoxy ketone and protein crosslinker.
SGTC_1527 coumarin 137 µM -0.682620849117398 0.265470978556646 no 2520 0.247423228094348 3677 323 A hepatotoxic, DNA x-linker.
SGTC_2749 bexarotene 57.39 µM -0.683857468898785 0.265091099506302 no 2521 0.247032586495668 3644 82146 An retinoic acid receptor inhibitor.
SGTC_2445 5742597 35.57 µM -0.686021579548107 0.264426968248393 no 2522 0.246349750260647 3623 1774255
SGTC_1702 st027038 51 µM -0.686245920090711 0.264358170166587 no 2523 0.246279022589734 3656 5521182
SGTC_793 0488-0545 106 µM -0.68751439632216 0.263969340503195 no 2524 0.245879315942213 3643 292548
SGTC_2758 dehydroepiandrosterone 69.35 µM -0.688042615908705 0.263807509840156 no 2525 0.245712972612328 3676 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem]
SGTC_677 0929-0063 136 µM -0.689208739973713 0.263450423557121 no 2526 0.245345958779736 3618 1539583
SGTC_144 4161-2749 112.381 µM -0.689573049084433 0.263338916743713 no 2527 0.245231360330329 3582 797501 YMR168C CEP3
SGTC_2018 5133068 143 µM -0.68985487987297 0.263252671222944 no 2528 0.245142726320786 3661 785362
SGTC_138 0850-0259 40.9225 µM -0.690244537571786 0.263133452406695 no 2529 0.245020209807699 3686 6813004
SGTC_3133 9127736 49.47 µM -0.690945440134922 0.262919075252365 no 2530 0.244799914353898 3666 27243420
SGTC_2175 5807670 165.306 µM -0.690976477246563 0.26290958434642 no 2531 0.244790161776664 3619 241186
SGTC_2319 6033012 152.6 µM -0.691136194973631 0.262860746685089 no 2532 0.244739978085949 3633 847246
SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM -0.692300532346151 0.262504861848089 no 2533 0.244374307929472 3667 688761
SGTC_324 1315-0088 19.6 µM -0.693204893152815 0.262228610275826 no 2534 0.244090488934949 3610 6787421
SGTC_1104 tacrolimus 29.8 µM -0.696668213147585 0.261172062462714 no 2535 0.243005227982768 3711 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41
SGTC_792 4534-1957 155 µM -0.697589922213963 0.260891247636205 no 2536 0.24271684292086 3667 1717904
SGTC_1442 4112-3290 3 µM -0.698714812258436 0.260548740703991 no 2537 0.242365137607348 3664 704353
SGTC_2692 st077426 47.7 µM -0.699246276754806 0.260387000764245 no 2538 0.242199067346555 3650 25238571
SGTC_2795 7780010 54.55 µM -0.699470819612604 0.260318681455591 no 2539 0.242128921480933 3666 953673
SGTC_1951 sophoraflavanone G 9.2 µM -0.699668189455686 0.260258637423461 no 2540 0.242067273402211 3694 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity.
SGTC_212 3807-4682 38.772 µM -0.700359256323678 0.260048456689956 no 2541 0.241851487129528 3767 3125501 YBL034C STU1
SGTC_1651 st011928 86.1 µM -0.701739749534883 0.259628856363121 no 2542 0.241420739515036 3674 720198
SGTC_1968 st069590 43.6 µM -0.7024620510653 0.25940945248186 no 2543 0.241195529964942 3631 6384066
SGTC_1695 st026914 34.495 µM -0.703073213462357 0.259223882684428 no 2544 0.241005062193921 3647 3289191
SGTC_1752 st044819 83.042 µM -0.705720650790841 0.258420823271408 no 2545 0.240180938027551 3658 441209 YML126C ERG13
SGTC_2549 cedrol 20.94 µM -0.705745751643065 0.25841321548635 no 2546 0.240173131708115 3623 6708665 A sedative which affects the nervous system.
SGTC_523 1934-0222 13.7 µM -0.706930279586295 0.258054330417242 no 2547 0.239804902955503 3685 1361595
SGTC_2304 7443016 91.4 µM -0.709556832613162 0.257259467532825 no 2548 0.238989498311677 3646 939854
SGTC_1205 4161-2785 76 µM -0.711477715666213 0.256678965392671 no 2549 0.23839412758891 3725 3498106
SGTC_1727 st034309 9.9045 µM -0.712082399028156 0.256496367775924 no 2550 0.23820687639721 3719 870305
SGTC_1486 3970-0793 4.53 µM -0.713171393027714 0.2561676925255 no 2551 0.237869852948432 3736 2844330
SGTC_1692 fluoroquinolonic acid 71 µM -0.713696120984016 0.256009399945307 no 2552 0.23770755277418 3701 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2
SGTC_385 1494-0393 12.4 µM -0.713703201974526 0.25600726420027 no 2553 0.237705363014804 3720 3090647
SGTC_2246 7293507 91.5585 µM -0.714129203966872 0.255878791985293 no 2554 0.237573644482647 3749 887656
SGTC_1844 rapamycin 4 nM -0.714249690886294 0.255842462059575 no 2555 0.237536397558149 3658 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2
SGTC_2096 5468907 200 µM -0.715378698451377 0.255502167900127 no 2556 0.237187535693974 3734 759785
SGTC_1386 3228-0095 33.8 µM -0.71621939291809 0.255248927875075 no 2557 0.236927945136217 3681 870181
SGTC_3289 9119912 71.43 µM -0.716572495329253 0.255142602977911 no 2558 0.236818960379987 3705 17014829
SGTC_2259 7964009 200 µM -0.717651014097317 0.254817986859265 no 2559 0.236486247240227 3705 313134
SGTC_3272 9137413 49.47 µM -0.717922009866839 0.25473645566258 no 2560 0.236402687992233 3660 17614870
SGTC_469 w7 172 µM -0.719160335317391 0.254364069645868 no 2561 0.236021067732251 3749 45115570 A P450 inhibitor.
SGTC_3282 9108498 15.4605 µM -0.719704392711254 0.254200552382328 no 2562 0.235853510539479 3694 16459645
SGTC_2733 amorolfine 100 µM -0.721136182078739 0.253770489503259 no 2563 0.235412865797339 3724 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_963 1269-2853 151 µM -0.721796701077687 0.253572219957122 no 2564 0.235209738993606 3718 3668223
SGTC_2719 novobiocin 32.65 µM -0.722074476856103 0.253488863660147 no 2565 0.235124344621029 3701 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication.
SGTC_2977 9011197 71.43 µM -0.722515121993339 0.253356662281741 no 2566 0.234988915765859 3711 2704722
SGTC_1348 1493-0373 93.8 µM -0.723236436472714 0.253140333353675 no 2567 0.234767318420881 3710 3010129
SGTC_691 1548-0686 185 µM -0.725292656844367 0.25252418734533 no 2568 0.234136254838617 3715 46495133
SGTC_354 2783-3500 4.88 µM -0.725474261418016 0.252469807573572 no 2569 0.234080564730673 3707 6740761
SGTC_520 3584-0023 682 µM -0.72748414634456 0.251868378864028 no 2570 0.233464711841082 3737 1340790
SGTC_3295 9122362 53.5725 µM -0.729616364033403 0.251231171541843 no 2571 0.232812358384553 3741 4730473
SGTC_3014 9081533 49.47 µM -0.729662458572003 0.251217405737215 no 2572 0.232798266922217 3720 21367265
SGTC_552 k242-0005 476 µM -0.731560534886307 0.250650905368851 no 2573 0.232218421819643 3758 4088318
SGTC_2052 5265182 7.135 µM -0.73159687495866 0.250640065906298 no 2574 0.232207328103664 3722 1239884
SGTC_1030 k029-0042 36.7 µM -0.732405282797916 0.250398999433956 no 2575 0.231960617662208 3736 6080581
SGTC_3051 9093778 49.47 µM -0.733304248511574 0.250131073071273 no 2576 0.231686442194952 3750 17217378
SGTC_1704 st028805 70.8 µM -0.734186345542769 0.249868322111432 no 2577 0.231417587132253 3745 2876101
SGTC_1821 st053465 65.6 µM -0.735437932343232 0.249495762502376 no 2578 0.231036413704463 3713 675086
SGTC_1748 st037455 53.6035 µM -0.737959434059007 0.248746084841209 no 2579 0.230269550224948 3732 580690
SGTC_2703 st077852 53.4 µM -0.738144513887543 0.248691105315929 no 2580 0.23021331809248 3710 6281836
SGTC_661 1304-0007 33.6 µM -0.7382779901019 0.248651459096796 no 2581 0.230172769266306 3747 3117130
SGTC_1248 0469-0687 58.6 µM -0.742242104022434 0.247475541088085 no 2582 0.228970331393022 3748 4017482
SGTC_2239 6685329 187.64 µM -0.742339873973847 0.247446576126349 no 2583 0.22894071936014 3791 805680
SGTC_2076 5212012 200 µM -0.743577630151849 0.247080039790979 no 2584 0.228566020347733 3652 604802
SGTC_3277 9138724 49.47 µM -0.743901837610651 0.246984080364872 no 2585 0.228467931793548 3698 15943418
SGTC_3275 9138069 49.47 µM -0.744000475016336 0.246954889469597 no 2586 0.228438093864746 3833 17617007
SGTC_1865 st057639 52.2 µM -0.744746671424095 0.246734118859749 no 2587 0.228212439539298 3743 688818
SGTC_1835 st008666 49.2 µM -0.744922194067757 0.246682203865829 no 2588 0.228159378636755 3681 690455
SGTC_1391 3442-0225 151 µM -0.744974748507339 0.246666660779184 no 2589 0.228143492657203 3707 5227075
SGTC_2568 diosmetin 100 µM -0.74597834690895 0.246369945096019 no 2590 0.227840247666678 3745 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.
SGTC_2049 5262831 67.185 µM -0.746941698282579 0.246085308567276 no 2591 0.227549377098242 3788 763417
SGTC_1151 3909-8316 15.3 µM -0.747084382640451 0.246043165348976 no 2592 0.227506313324463 3787 800431
SGTC_320 4092-0846 5.34 µM -0.747208353853868 0.246006552384232 no 2593 0.227468901118736 3737 1359356
SGTC_128 0906-2981 13.371 µM -0.747360344625512 0.245961668268934 no 2594 0.227423037860462 3704 6740226
SGTC_553 k007-0256 45.7 µM -0.747663187436083 0.245872249417255 no 2595 0.227331670488058 3799 6287000
SGTC_1981 st071826 47 µM -0.748182635373256 0.245718915312835 no 2596 0.227175001737173 3746 11838600
SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM -0.75009519129586 0.245154797127066 no 2597 0.226598687737759 3560 4000243
SGTC_642 0335-0876 158 µM -0.750801226551562 0.244946724548258 no 2598 0.226386145576611 3772 6812350
SGTC_2812 7970281 58.44 µM -0.751024087260368 0.244881065974593 no 2599 0.226319079824775 3780 2233435
SGTC_1893 st059353 36.1 µM -0.75275166438155 0.244372413675361 no 2600 0.225799578728018 3784 3112488
SGTC_190 3970-0790 3.722 µM -0.75453884827183 0.243846811065864 no 2601 0.225262863722611 3708 2832352
SGTC_1292 0kpi-0043 232 µM -0.755439093489228 0.243582284306958 no 2602 0.224992782032505 3786 3333905
SGTC_1073 triclabendazole 3.09 µM -0.75624712130954 0.243344986616023 no 2603 0.224750522756122 3840 50248 An antihelmetic and likely tubulin inhibitor.
SGTC_1423 4048-0112 5.59 µM -0.756646094560048 0.24322786417509 no 2604 0.224630958958296 3777 X1423
SGTC_173 1273-0061 2.693 µM -0.7567892900481 0.243185835192723 no 2605 0.224588055116275 3753 2847414 YPL266W DIM1
SGTC_1175 0741-0056 27.6 µM -0.757276770867202 0.243042785245216 no 2606 0.22444203229754 3833 765927
SGTC_2722 naftopidil 47.16 µM -0.757394834880774 0.243008146522245 no 2607 0.224406674827992 3705 4418 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_826 1683-5028 118 µM -0.758028877622723 0.242822170825936 no 2608 0.224216847625155 3822 722377
SGTC_1683 st010134 710 nM -0.758707909396046 0.24262308451638 no 2609 0.224013652226863 3783 3818134
SGTC_296 1222-0039 74.9 µM -0.758935605459486 0.242556345770322 no 2610 0.223945539238443 3735 5984176
SGTC_407 eburnamonine 100 µM -0.761180579511747 0.241898866276383 no 2611 0.223274608125631 3665 3195
SGTC_2982 9019404 25.97 µM -0.761256697444259 0.24187659078258 no 2612 0.223251879652986 3694 22333232
SGTC_3187 9109394 49.47 µM -0.761935159095124 0.241678091893962 no 2613 0.223049352242669 3736 17098090
SGTC_285 1486-1325 46 µM -0.762191850008821 0.241603014381203 no 2614 0.222972754794396 3775 22310230
SGTC_1691 st019933 84.6 µM -0.762472700847712 0.241520885030557 no 2615 0.222888965108301 3734 6176082
SGTC_318 1488-0629 67.2 µM -0.76286536465814 0.241406083579297 no 2616 0.222771846960106 3827 3662576
SGTC_3099 9120367 49.47 µM -0.76348503671734 0.241224973009992 no 2617 0.222587091397543 3789 24824940
SGTC_2261 9010538 184.68 µM -0.764119200608652 0.241039703421179 no 2618 0.222398105566116 3719 6457250
SGTC_1539 benzyladenosine 56 µM -0.765171118732247 0.240732558545689 no 2619 0.222084827590153 3757 92208 A nucleotide analog.
SGTC_932 2857-0803 154 µM -0.766698513503378 0.24028696079491 no 2620 0.221630393832883 3887 674898
SGTC_2537 larixol 68.93 µM -0.768040562045216 0.239895806629196 no 2621 0.221231543627884 3782 6708759
SGTC_2189 6047310 154.431 µM -0.768439613537733 0.239779565896425 no 2622 0.221113026734535 3729 711535
SGTC_2786 7743617 45.45 µM -0.768725447487989 0.239696323484709 no 2623 0.221028157389134 3747 583674
SGTC_1822 st052468 42 µM -0.769012181488418 0.239612834802165 no 2624 0.220943039536593 3794 2873678
SGTC_2140 5586273 200 µM -0.770953940070133 0.2390478685596 no 2625 0.220367116650882 3754 854421
SGTC_209 4077-0173 175.592 µM -0.771740232357114 0.238819299439009 no 2626 0.220134148469803 3740 15993494
SGTC_411 enrofloxacin 100 µM -0.77223471553427 0.238675618233808 no 2627 0.219987711914757 3831 71188 A bacterial gyrase inhibitor.
SGTC_1887 st057648 70.8 µM -0.772949372907518 0.238468044965413 no 2628 0.219776171629494 3827 688672
SGTC_1642 st009582 77.7 µM -0.772992176081818 0.238455615859356 no 2629 0.21976350549542 3751 6739311
SGTC_2240 6690706 185.951 µM -0.773446270341022 0.238323778657536 no 2630 0.219629157652984 3695 805876
SGTC_2477 5967686 25.23 µM -0.775859041358356 0.237623948819402 no 2631 0.218916109348118 3811 776118
SGTC_3030 9087619 49.47 µM -0.77586161232366 0.237623203706851 no 2632 0.218915350259478 3822 25236973
SGTC_3308 9128332 17.569 µM -0.775886132979995 0.237616097238661 no 2633 0.218908110505596 3781 17332805 YDL196W YDL196W
SGTC_2741 miltefosine 3.04 µM -0.776484198110318 0.2374428047623 no 2634 0.21873157369436 3753 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis.
SGTC_1167 k781-0610 148 µM -0.776913801928459 0.237318367656931 no 2635 0.218604813860235 3805 4525169
SGTC_2426 5582046 32.21 µM -0.777178873820598 0.237241605996755 no 2636 0.218526622274668 3780 2251934
SGTC_1586 deoxycorticosterone acetate 53.7 µM -0.778283469910623 0.236921875010349 no 2637 0.218200959120875 3747 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE.
SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM -0.77913716705199 0.236674930380238 no 2638 0.21794945910057 3713 17037758
SGTC_3076 9116187 49.47 µM -0.781471554616725 0.236000397446608 no 2639 0.217262600272266 3789 27241210
SGTC_2099 5377090 177.372 µM -0.781939488987969 0.235865313049936 no 2640 0.217125068115722 3822 2243829
SGTC_2216 7189485 200 µM -0.782995877085175 0.235560509233367 no 2641 0.216814766578847 3794 731273
SGTC_2623 humulene 100 µM -0.785502921320289 0.234838012468825 no 2642 0.216079379095482 3764 6187145 An anti-inflammatory.
SGTC_3241 9133421 49.47 µM -0.785537497184568 0.234828056735246 no 2643 0.216069247119703 3819 17018221
SGTC_1018 4259-0013 28.1 µM -0.785735408193154 0.234771074962552 no 2644 0.216011257349084 3902 6801262
SGTC_606 k015-0008 38.6 µM -0.786232966449062 0.2346278536828 no 2645 0.215865507973868 3848 1970475
SGTC_2469 5655019 90.81 µM -0.786497095645031 0.23455184419027 no 2646 0.215788159964077 3879 2788239
SGTC_2776 terbinafine 19.92 µM -0.788918497561112 0.233855663038033 no 2647 0.215079821849081 3838 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_735 3076-0345 636 µM -0.789321938023937 0.233739780608765 no 2648 0.214961933848027 3858 2888990
SGTC_2104 5389443 200 µM -0.789965414709311 0.233555017139684 no 2649 0.214773983337198 3864 2244536
SGTC_82 0054-0107 293.755 µM -0.790216258309119 0.233483013580856 no 2650 0.214700741314456 3803 3104697
SGTC_1914 st062367 72.6 µM -0.792109863013525 0.232939860118534 no 2651 0.214148309805952 3837 978205
SGTC_3161 9100388 49.47 µM -0.792798092403906 0.232742625381049 no 2652 0.21394773405118 3832 25236368
SGTC_2136 5328288 199.296 µM -0.795307053682792 0.232024386573874 no 2653 0.213217455718683 3847 262395
SGTC_1806 st050005 60.3 µM -0.796833100811792 0.231588130270175 no 2654 0.212773984127967 3837 5194765
SGTC_2933 9026794 32.47 µM -0.798948003225165 0.230984292471588 no 2655 0.212160281382668 3833 17586027
SGTC_119 0121-0043 24.815 µM -0.801174491483626 0.230349545978328 no 2656 0.211515318193633 3895 1092378
SGTC_1398 3558-0053 112 µM -0.801526039273347 0.230249412930598 no 2657 0.211413587811369 3741 4532369
SGTC_2342 7990637 118.86 µM -0.801689563894195 0.230202843723416 no 2658 0.211366277063477 3908 2033102 YER133W GLC7
SGTC_1978 st071761 42 µM -0.802195463624588 0.230058804906344 no 2659 0.211219950032692 3862 5147680
SGTC_2876 9059903 25.97 µM -0.803069965163188 0.229809937451815 no 2660 0.210967148210013 3770 6916095
SGTC_782 0083-0095 30.5 µM -0.803128437233345 0.229793302727335 no 2661 0.210950251371904 3822 3591729 An indicator and reagent.
SGTC_1196 1588-0294 184 µM -0.804807793577228 0.229315830345345 no 2662 0.210465301790197 3856 6144269
SGTC_1276 0871-0068 94.2 µM -0.810393108928875 0.227731828504234 no 2663 0.208857138578733 3843 3414906
SGTC_3087 9117406 49.47 µM -0.812484137345578 0.227140398641122 no 2664 0.208256942515225 3819 42546093
SGTC_2372 9071633 200 µM -0.812663919533353 0.227089589209002 no 2665 0.208205386481962 3910 21321366
SGTC_3043 9092303 49.47 µM -0.812679012318723 0.227085324028755 no 2666 0.20820105867538 3859 25236084
SGTC_1563 conessine 56.1 µM -0.813272565711425 0.226917623265707 no 2667 0.208030901287895 3912 441082 An anti-amoebic, histamine inhibitor.
SGTC_623 k072-0108 16.9 µM -0.814782286261988 0.226491386372576 no 2668 0.207598471074752 3853 5382803
SGTC_1068 loratadine 26.9 µM -0.817282128123906 0.22578660514661 no 2669 0.206883608835441 3909 3957 A H1 histamine antagonist.
SGTC_537 1334-0398 209 µM -0.8177184423898 0.225663722195158 no 2670 0.206758988614129 3820 5846986
SGTC_2011 4012611 177 µM -0.818967885583004 0.225312040133809 no 2671 0.206402368195172 3883 2049887
SGTC_2510 benzyl isothiocyanate 8.31 µM -0.819009815595762 0.225300243435005 no 2672 0.206390406709468 3824 2346 DNA damaging agent; causes G2/M arrest.
SGTC_9 0092-0002 10.449 µM -0.820948666039814 0.224755144368031 no 2673 0.205837754460261 3832 759368
SGTC_2448 5185112 27.17 µM -0.820974053483918 0.224748011766481 no 2674 0.205830523821254 3879 5718189
SGTC_1361 1608-0041 5.61 µM -0.821341035951704 0.224644922394361 no 2675 0.205726019786207 3821 X1361
SGTC_1275 0867-0008 21.1 µM -0.822422187958992 0.224341370977341 no 2676 0.205418327816558 3828 3422836
SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM -0.82247548733997 0.224326412313855 no 2677 0.20540316607672 3881 6728940
SGTC_1089 terbinafine 2.25 µM -0.823019966579355 0.224173634691234 no 2678 0.205248319567144 3873 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_1359 1582-0056 520 nM -0.823295880598924 0.224096237429189 no 2679 0.205169877819894 3952 3661189
SGTC_1390 3413-2614 145 µM -0.823299103691976 0.224095333401805 no 2680 0.205168961606922 3909 3421432
SGTC_1764 st044502 93.5 µM -0.824116630155696 0.223866096874087 no 2681 0.204936645864157 3922 8407
SGTC_2408 sulbentine 18.36 µM -0.824200345462969 0.223842630410673 no 2682 0.204912865393015 3864 67686 An antifungal agent of unknown mechanism. YDL205C HEM3
SGTC_71 0417-1750 47.813 µM -0.82455303213717 0.223743783211837 no 2683 0.204812697965922 3805 6811472
SGTC_863 0466-0191 129 µM -0.826644465346942 0.223158129113072 no 2684 0.204219303359788 3911 765160 YPR165W RHO1
SGTC_2800 7887935 81.82 µM -0.827160218654763 0.223013839429063 no 2685 0.204073128103518 3900 2961002
SGTC_2272 7805186 180 µM -0.828353930858568 0.222680084512643 no 2686 0.203735044304698 3878 2956062 YPR165W RHO1
SGTC_2218 6965428 192.983 µM -0.829122571224529 0.222465327952353 no 2687 0.203517526412466 3794 675684
SGTC_2866 9034245 58.44 µM -0.830539299255684 0.222069806662666 no 2688 0.203116969027868 3847 6462273
SGTC_2124 5246320 200 µM -0.83059105586338 0.222055364888026 no 2689 0.203102344584697 3894 579342
SGTC_1922 5578187 25 µM -0.831544946695697 0.221789294379785 no 2690 0.202832923998226 3851 1350412
SGTC_2142 5622915 118.518 µM -0.831598199125411 0.221774445951751 no 2691 0.202817889472695 3898 5322196
SGTC_2525 harmine 47.85 µM -0.831780216922539 0.221723698035977 no 2692 0.202766506211296 3890 5280953 A monoamine oxidase inhibitor
SGTC_93 0109-0045 59.227 µM -0.835224459362723 0.220764669004043 no 2693 0.201795670265577 3954 88733
SGTC_3097 9117246 49.47 µM -0.835817493849953 0.22059978209715 no 2694 0.201628791704999 3890 16423892
SGTC_431 k089-0097 107 µM -0.836119149418796 0.220515937066627 no 2695 0.201543938241133 3787 5499420
SGTC_1797 st048695 56.8 µM -0.836798719715647 0.220327117728696 no 2696 0.201352858588914 3858 592262 YIL048W NEO1
SGTC_32 0928-0142 34.1 µM -0.837511898392374 0.220129059981119 no 2697 0.201152445848476 3832 2244242
SGTC_1485 3909-9022 254 µM -0.838489831265117 0.219857643100857 no 2698 0.200877828200116 3924 714516
SGTC_2314 7727897 200 µM -0.84053397981354 0.219290927989792 no 2699 0.200304528899687 3906 900724
SGTC_2709 st078560 56 µM -0.841212346808345 0.21910304476399 no 2700 0.20011449241953 3858 17250903
SGTC_811 0416-0114 265 µM -0.841248673690679 0.219092986137622 no 2701 0.200104318931655 3964 6612453
SGTC_1647 st011722 22.4 µM -0.841691582166916 0.218970369640016 no 2702 0.199980305655567 3847 2854783
SGTC_3268 9137683 49.47 µM -0.843381086586693 0.218503003303345 no 2703 0.199507673114831 3918 1953228
SGTC_2421 5690543 90.72 µM -0.843641765433636 0.218430943096506 no 2704 0.199434809100886 3942 3397993
SGTC_698 k064-0052 127 µM -0.84406810848083 0.218313117359281 no 2705 0.19931567375769 3942 5088751
SGTC_1141 3253-0389 52.6 µM -0.844516420934716 0.218189259579194 no 2706 0.199190445619256 3841 5402031
SGTC_340 k038-0059 454 µM -0.848258673751683 0.217156947563509 no 2707 0.19814696367043 3889 23733424
SGTC_2222 6885208 172.143 µM -0.849144099919019 0.216913113438955 no 2708 0.197900556949013 3844 609514
SGTC_770 0389-1121 67.2 µM -0.850967464941996 0.216411482763675 no 2709 0.197393713083598 4043 6753108
SGTC_1520 flindersine 88 µM -0.851004256185345 0.216401367944394 no 2710 0.197383494245761 4043 68230 Flindersine is a natural alkaloid of the quinoline subtype.
SGTC_1318 1280-3875 124 µM -0.851370209957585 0.216300773132946 no 2711 0.197281867308303 3931 373245
SGTC_556 4058-0063 51.5 µM -0.854295600751735 0.215497603909258 no 2712 0.196470612055526 3959 6615692
SGTC_3083 9117465 49.47 µM -0.856382884318247 0.214925596876888 no 2713 0.195893014370991 3868 16420915
SGTC_3351 9150312 21.596 µM -0.856895802580553 0.214785169922992 no 2714 0.195751236367124 3855 4904905
SGTC_3266 9136860 49.47 µM -0.859215731790323 0.214150685024478 no 2715 0.195110752771606 3798 4871271 YPR165W RHO1
SGTC_3085 9117376 49.47 µM -0.859327186250832 0.214120230467185 no 2716 0.195080014643924 4012 16480349
SGTC_1137 ixabepilone 100 µM -0.860761784761074 0.213728456294706 no 2717 0.194684628253178 3873 154225 A novel microtubule stabilizer.
SGTC_491 tetrandrine 80.3 µM -0.861209218715818 0.213606352131316 no 2718 0.194561411825076 3925 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_1740 st038286 13.222 µM -0.863462002304242 0.212992188115328 no 2719 0.193941751205136 3975 716786
SGTC_619 1652-1634 108 µM -0.863595933029739 0.212955707794748 no 2720 0.193904949542666 3886 5400454
SGTC_1756 st041558 35.5 µM -0.86757346253927 0.211873963359413 no 2721 0.192813939657681 3985 3955792
SGTC_95 0471-0001 561.058 µM -0.868192938859253 0.211705777957996 no 2722 0.19264435956918 3917 4015405
SGTC_1799 st045822 46.1415 µM -0.868220964195885 0.211698171036401 no 2723 0.192636689859279 3860 3674992
SGTC_54 0159-0055 9 µM -0.868920504896481 0.211508346429485 no 2724 0.192445306625185 3901 3319099
SGTC_1239 0337-0584 35.4 µM -0.870101676781749 0.211188054594421 no 2725 0.192122420718154 4011 914301 YML130C ERO1
SGTC_1106 tegaserod maleate 11.7 µM -0.87058430551011 0.211057264669484 no 2726 0.191990584460131 3933 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation.
SGTC_1079 idarubicin 2.36 µM -0.872418444934971 0.210560655486569 no 2727 0.191490070854839 3921 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_689 0833-0039 98 µM -0.872782670168855 0.210462120008872 no 2728 0.191390773587678 3905 5374726
SGTC_1975 st070967 30.8 µM -0.874089779806457 0.210108724736441 no 2729 0.19103468140929 3889 261391
SGTC_351 caspofungin 25 nM -0.874223336074609 0.210072635580956 no 2730 0.190998319946616 3937 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1
SGTC_592 k241-0073 46.5 µM -0.875432997154922 0.209745930669183 no 2731 0.190669176128501 3930 4230158
SGTC_1080 nisoldipine 24.4 µM -0.876406536689234 0.20948321448558 no 2732 0.190404533015998 3927 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class.
SGTC_60 0986-0278 202 µM -0.876944664180326 0.209338080284494 no 2733 0.190258347435451 3880 3110598
SGTC_962 1254-0300 21.5 µM -0.878127676351227 0.209019227346906 no 2734 0.189937217527022 3919 7340576
SGTC_2019 4016004 108 µM -0.878201865969945 0.20899924082656 no 2735 0.189917089785978 3970 45595336
SGTC_2705 st078069 42.8 µM -0.879607252450298 0.208620845461507 no 2736 0.189536054320935 3994 1530061
SGTC_3312 9133330 71.43 µM -0.880461464102997 0.208391049447181 no 2737 0.189304686157239 3993 17617324
SGTC_430 0958-0115 16.4 µM -0.881042849679744 0.208234733244598 no 2738 0.189147313994628 3907 6833180
SGTC_586 0957-0265 8.15 µM -0.882888650405024 0.207738914487173 no 2739 0.18864821817386 3834 6752309 YPR165W | YPR107C RHO1 | YTH1
SGTC_1302 1159-0335 255 µM -0.884876014826067 0.207205849333326 no 2740 0.188111752772625 3955 649284
SGTC_2826 7992541 19.48 µM -0.885890644106836 0.206934010420009 no 2741 0.187838229086567 3976 2985066
SGTC_227 fluconazole 33.516 µM -0.886942922844141 0.206652307556719 no 2742 0.187554815457461 3946 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C
SGTC_540 1187-0821 17.3 µM -0.892118974992547 0.205269949278082 no 2743 0.186164582662613 3907 847520
SGTC_2658 polymyxin b sulfate 77.05 µM -0.894930100301439 0.204521494995348 no 2744 0.185412227503372 3974 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides. YIL048W NEO1
SGTC_2349 9023730 187.07 µM -0.895855475751561 0.204275472098911 no 2745 0.18516497826639 3986 4126287
SGTC_2344 7990960 76.95 µM -0.896223220251144 0.204177751470823 no 2746 0.185066778227487 3945 140813
SGTC_1189 1431-2119 7.28 µM -0.897155403291779 0.203930167537064 no 2747 0.1848179992679 3977 3107275
SGTC_1362 1611-0397 101 µM -0.898864207781689 0.203476781010065 no 2748 0.184362497355977 3925 27816
SGTC_2064 5220758 200 µM -0.899424981203854 0.20332812560523 no 2749 0.184213168956308 4028 788518
SGTC_2962 9082311 13.18 µM -0.900794279669879 0.202965410759039 no 2750 0.183848854787085 3966 16459453
SGTC_3094 9117742 49.47 µM -0.903068842484063 0.202363754317229 no 2751 0.183244679540332 3907 17149698
SGTC_880 0833-0487 87.2 µM -0.903312683772325 0.202299317951248 no 2752 0.183179983354721 3962 76075
SGTC_3073 9114972 49.47 µM -0.903528399463279 0.202242324156719 no 2753 0.183122761355626 3955 41905075
SGTC_621 3584-0052 32.1 µM -0.904157953963619 0.202076045800579 no 2754 0.182955825832858 3959 2273927
SGTC_2128 5255449 168.493 µM -0.90451891968398 0.201980744205302 no 2755 0.182860153375224 3969 736008
SGTC_193 1273-0060 1.558 µM -0.904968127719263 0.20186218259301 no 2756 0.182741136278336 3789 2847393 YHR072W ERG7
SGTC_2420 aureobasidin a 50 nM -0.906574827003383 0.201438459983514 no 2757 0.182315839306415 4114 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1
SGTC_1907 st060210 83.7 µM -0.907956375327523 0.201074541292363 no 2758 0.181950635292223 4031 688793
SGTC_2797 7859098 81.82 µM -0.908827203011091 0.200845356141586 no 2759 0.181720672445527 3975 972681
SGTC_1708 st033234 31.827 µM -0.909290898239209 0.20072338443262 no 2760 0.181598296872065 4082 674664
SGTC_1082 camptothecin 424.86 nM -0.910115427355067 0.200506607808965 no 2761 0.181380819677069 3896 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_1220 1838-0075 193 µM -0.912093285968848 0.199987183242728 no 2762 0.180859806207362 3903 5529645
SGTC_1136 pergolide 1.05886 µM -0.913366005514658 0.199653370280508 no 2763 0.180525039123803 3972 47811 A dopamine receptor agonist.
SGTC_654 1124-0271 80.9 µM -0.913908502031077 0.199511184525843 no 2764 0.18038246292103 3972 5403748
SGTC_1891 st059073 26.2 µM -0.914161355270113 0.199444933724695 no 2765 0.18031603345135 4075 688754
SGTC_1526 st051518 75 µM -0.914811776977984 0.199274575730183 no 2766 0.180145225547122 3997 673993
SGTC_2139 5578692 56.4705 µM -0.917219875348318 0.198644611528622 no 2767 0.179513716929428 3940 650991 YMR113W FOL3
SGTC_1393 3470-5649 58.2 µM -0.91818566265433 0.198392297098246 no 2768 0.179260836717895 3972 4108395
SGTC_869 0564-0080 44.1 µM -0.919985285774607 0.197922657115502 no 2769 0.178790224265923 4023 6843321
SGTC_2055 5235184 200 µM -0.922512487481583 0.197264278877844 no 2770 0.178130659879919 4066 2836034
SGTC_2844 9010103 25.97 µM -0.92355983061859 0.196991817253955 no 2771 0.177857768053815 4049 2480525
SGTC_2782 7736369 71.43 µM -0.924554022235952 0.196733393616126 no 2772 0.177598969280888 4031 2950836 YOL077C BRX1
SGTC_1428 4049-0204 61.7 µM -0.926355918901497 0.196265544043224 no 2773 0.177130522224658 4064 X1428
SGTC_806 3966-4455 5.86 µM -0.927362401923036 0.196004511797939 no 2774 0.176869202440149 3981 714982
SGTC_1453 4237-0541 195 µM -0.929407643366273 0.195474725865399 no 2775 0.176338934092754 3993 739892
SGTC_578 3460-0051 92 µM -0.930488783531278 0.195195026123624 no 2776 0.176059034457903 4084 2876744
SGTC_3055 9094636 49.47 µM -0.930558294566395 0.195177051379583 no 2777 0.176041048165097 4023 25236176
SGTC_1792 st045773 43.6 µM -0.934296882512502 0.194211778671082 no 2778 0.175075385996192 3947 2919270
SGTC_3107 9121808 49.47 µM -0.935911889863525 0.193795697870781 no 2779 0.17465927745857 3892 662681
SGTC_1881 5652484 16 µM -0.938127359167385 0.193225802463721 no 2780 0.174089481637019 3987 2255129
SGTC_3313 9133968 57.047 µM -0.938654769676246 0.193090285110362 no 2781 0.173954011426169 4002 1494643
SGTC_2472 5377652 49.4 µM -0.939873643411775 0.192777319390496 no 2782 0.17364118910092 4097 1610903
SGTC_620 0109-0052 432 µM -0.945493040448317 0.191338459654761 no 2783 0.172203611108244 4016 493037
SGTC_3048 9093155 49.47 µM -0.946238402820614 0.191148103530673 no 2784 0.172013501462502 3982 25236002
SGTC_1069 diphenylcyclopropenone 8.49 µM -0.947058258254395 0.190938856975776 no 2785 0.171804546663161 4060 65057 A dermal irritant. YDR527W RBA50
SGTC_216 k038-0035 28.382 µM -0.94761489897747 0.190796869175542 no 2786 0.171662769269216 3952 4444231 YPR107C YTH1
SGTC_1559 coumarin 343 70.1 µM -0.949210414560084 0.190390244524904 no 2787 0.171256802874456 4067 108770 A hepatotoxic, DNA x-linker.
SGTC_1467 k284-1082 293 µM -0.949630344354648 0.190283311977987 no 2788 0.171150057162838 4002 3334705
SGTC_201 4262-0159 12.803 µM -0.95070864571784 0.19000889819423 no 2789 0.170876149049454 4057 1341029
SGTC_3106 9121286 49.47 µM -0.952166665635644 0.189638237979331 no 2790 0.170506231838804 4057 15943471
SGTC_2284 7945075 39.21 µM -0.9532010545151 0.189375543851735 no 2791 0.170244106109699 4052 1245402
SGTC_2324 6149169 200 µM -0.953696231093822 0.189249867773122 no 2792 0.170118714247383 3938 2888231
SGTC_3179 9107801 49.47 µM -0.953974968284807 0.189179146718859 no 2793 0.170048156628793 4038 4818259
SGTC_2961 9083290 32.55 µM -0.955562171009706 0.188776752711423 no 2794 0.16964674058705 3967 17741490
SGTC_3244 9134489 49.47 µM -0.956665272664385 0.188497400895397 no 2795 0.16936811583135 4053 16584271
SGTC_2860 9025725 38.96 µM -0.95770961789744 0.18823316373024 no 2796 0.169104602764302 4053 40546248
SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM -0.957894547685147 0.188186397168376 no 2797 0.169057968046595 4040 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding.
SGTC_1964 st076914 61 µM -0.958890056498057 0.18793476793923 no 2798 0.168807067272839 4077 24208661
SGTC_1693 xanthone 101.9 µM -0.962540207365165 0.187013918129876 no 2799 0.167889158122593 4087 7020 An insecticide.
SGTC_1065 prochlorperazine maleate 2.48 µM -0.963117878605743 0.186868441106532 no 2800 0.167744185269957 4087 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine.
SGTC_3001 9076041 71.4286 µM -0.964674013802051 0.186476902538835 no 2801 0.167354057480729 4032 16004211
SGTC_375 3970-0961 9.27 µM -0.965926048126521 0.18616224782574 no 2802 0.16704059353292 4003 2898222
SGTC_2616 abietic acid 100 µM -0.967806049513805 0.185690394158338 no 2803 0.166570620990433 4076 6708678 Abietic acid is an inhibitor of 5α-reductase.
SGTC_2374 9071832 200 µM -0.969335552202819 0.185307058586127 no 2804 0.166188898192886 3959 17381698
SGTC_2948 9070189 9.45 µM -0.970599114465208 0.184990745938579 no 2805 0.165873973559118 4005 6473636 YDL196W YDL196W
SGTC_2909 7941780 10.49 µM -0.971498470837742 0.184765810917533 no 2806 0.165650057117924 4016 1243215
SGTC_162 k030-0015 37.8 µM -0.971599794968799 0.18474047973792 no 2807 0.165624842290669 4137 1809920 YMR134W ERG29
SGTC_2884 9058502 51.95 µM -0.973533766838485 0.184257397910213 no 2808 0.165144043187724 4108 6471554
SGTC_1946 st076057 65.1 µM -0.97421325056609 0.184087858210829 no 2809 0.164975333410183 3995 953009
SGTC_2070 5230947 200 µM -0.974232599748255 0.184083031770069 no 2810 0.164970530814851 4138 2835538
SGTC_406 estrone 100 µM -0.974580703987854 0.183996214451994 no 2811 0.164884144499257 4052 5870 A steroid.
SGTC_2078 5212016 200 µM -0.974787227041611 0.183944719582064 no 2812 0.1648329071319 3916 1899708
SGTC_3321 9137793 26.8275 µM -0.980073018315382 0.182629805431582 no 2813 0.163525038359266 4028 4904192
SGTC_603 3794-0023 45.9 µM -0.981087918621647 0.18237800817294 no 2814 0.163274693825594 4113 3802260
SGTC_1815 st051655 58.2 µM -0.98186732152818 0.182184785252697 no 2815 0.163082608355713 4024 5984156
SGTC_1616 st002734 56.1 µM -0.98298698228831 0.18190743253723 no 2816 0.162806922796995 4011 4026101
SGTC_1851 st056236 18.9 µM -0.984811304405181 0.181456093178974 no 2817 0.162358383429107 4078 5393171
SGTC_931 2812-0076 566 µM -0.988983466132944 0.180426533295366 no 2818 0.161335615585041 4036 3450959
SGTC_688 0527-0193 473 µM -0.9889862949061 0.180425836487603 no 2819 0.161334923565424 4113 4007154
SGTC_40 0327-0103 19.753 µM -0.990290726343225 0.180104697602876 no 2820 0.161016019022687 3942 409036
SGTC_3104 9120930 49.47 µM -0.9907059701867 0.180002543773814 no 2821 0.160914587501771 4107 17014836
SGTC_2419 paclitaxel 166.5 µM -0.990843918147944 0.179968615350864 no 2822 0.160880900215864 4009 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_39 0986-0283 58.349 µM -0.991626857993034 0.179776126689501 no 2823 0.160689791294216 4160 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2
SGTC_2715 st079500 56.4 µM -0.992050469852444 0.179672034084667 no 2824 0.160586453093738 4038 28246688
SGTC_1965 Pectolinarigenin 58.4 µM -0.992065995068174 0.179668219849306 no 2825 0.160582666612245 4046 5320438 An anti-inflammatory.
SGTC_1016 4226-1401 38 µM -0.99207418314485 0.179666208222931 no 2826 0.160580669626396 4048 2901613
SGTC_887 0885-0007 9.62 µM -0.992389275692278 0.179588807818533 no 2827 0.160503834188756 4154 5719458
SGTC_2247 cerulenin 830 nM -0.992816528597564 0.179483889440164 no 2828 0.160399686775785 4134 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12
SGTC_795 0685-0265 78 µM -0.994747491552579 0.179010193147587 no 2829 0.159929545037064 4103 302754
SGTC_3315 9136395 68.55 µM -0.9947994776209 0.178997451012075 no 2830 0.159916900186152 4088 16876844
SGTC_2597 laccaic acid a 100 µM -0.997998850366581 0.178214361776263 no 2831 0.159139958055767 4104 5491415 A textile dye.
SGTC_482 fipronil 114 µM -0.998580106455224 0.178072323703156 no 2832 0.158999070519453 4164 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels.
SGTC_273 hydroxyurea 18.1 mM -1.00217839672728 0.177194620213684 no 2833 0.158128719822041 4160 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12
SGTC_2572 astragaloside iv 100 µM -1.00242465774951 0.177134651706835 no 2834 0.158069269007135 4151 45006101 An anti-inflammatory agent.
SGTC_467 ro 31-8220 72.8 µM -1.00467283323675 0.176587777821012 no 2835 0.157527206838204 4032 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7
SGTC_1730 st033808 45.1 µM -1.0052456007155 0.176448621653296 no 2836 0.157389301183311 4041 1045166
SGTC_546 peri-Naphthalide 147 µM -1.0068978087286 0.176047599843885 no 2837 0.156991942565354 4021 223824 A penicillin ester.
SGTC_1626 st003712 1.76 µM -1.0094712454594 0.175424128912745 no 2838 0.156374342573882 4139 24207035
SGTC_2369 9071472 200 µM -1.01183096720462 0.174853666843999 no 2839 0.155809440368187 4170 17296037
SGTC_751 0833-0568 350 µM -1.01216884403031 0.174772081682869 no 2840 0.155728665088807 4138 6954252
SGTC_1870 st057514 26.5 µM -1.01256098006739 0.174677425165612 no 2841 0.155634952838316 4089 5393161
SGTC_1847 st056231 15 µM -1.01493277142903 0.174105599706019 no 2842 0.155068937653209 4109 5393180
SGTC_3323 9138564 53.9225 µM -1.01545571688124 0.173979680799307 no 2843 0.154944322657339 4124 43912313 YNL103W MET4
SGTC_454 lyso-paf C-16 6.67 µM -1.01694768671237 0.173620750953371 no 2844 0.154589158150886 4118 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_2507 purpurin 79.67 µM -1.01723659059339 0.17355130254589 no 2845 0.154520446601473 4118 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1
SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM -1.01800399395053 0.173366915489531 no 2846 0.154338029014913 4089 6312947
SGTC_1843 st055809 45.5 µM -1.01827652127342 0.173301464285568 no 2847 0.154273281485025 4170 16413835
SGTC_1262 0737-0114 49.6 µM -1.01972987231489 0.172952687655339 no 2848 0.153928295102699 4189 765919
SGTC_1868 st057644 42.7 µM -1.02060000251733 0.172744087132275 no 2849 0.153721994142028 4115 688665
SGTC_1254 0550-0035 264 µM -1.02194924187726 0.172420944739653 no 2850 0.153402462335876 4176 15121435
SGTC_1162 k048-0130 20.1 µM -1.02222778631981 0.17235428148198 no 2851 0.153336551251551 4073 6797406
SGTC_1717 st033143 58.0435 µM -1.02260612301731 0.172263761561869 no 2852 0.153247056696524 4194 674616
SGTC_1682 st012968 530 nM -1.02320734658135 0.172119976686092 no 2853 0.153104910053004 4135 24207270
SGTC_913 3487-1245 167 µM -1.02345121883366 0.172061675562928 no 2854 0.153047276518844 4053 4016153
SGTC_224 benfluorex 43.875 µM -1.02375861294802 0.171988206597475 no 2855 0.152974651560654 4137 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis.
SGTC_921 1561-0023 372 µM -1.0318629079838 0.170058460771926 no 2856 0.151068172124779 4098 24050882
SGTC_1631 benzylvanillin 81.9 µM -1.03234401104563 0.169944341446544 no 2857 0.150955495250281 4210 75506
SGTC_218 alverine citrate 93.75 µM -1.03254313796945 0.169897122213683 no 2858 0.150908875045359 4167 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_653 0203-0016 55.2 µM -1.03312781079125 0.169758526581778 no 2859 0.150772045039667 4168 295302
SGTC_105 0111-0055 734.78 µM -1.0337320328185 0.169615373053645 no 2860 0.150630726782294 4133 5179370
SGTC_2254 7938975 95.19 µM -1.03677457250565 0.168895705486636 no 2861 0.149920464251645 4218 2969277
SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM -1.03799168865976 0.168608364880532 no 2862 0.149636962267156 4151 551469
SGTC_585 0kpi-0023 191 µM -1.03938827963141 0.168279040693914 no 2863 0.149312096342566 4078 64601
SGTC_899 1083-0020 478 µM -1.04095719303361 0.167909575713905 no 2864 0.14894770792763 4196 767123
SGTC_412 gemfibrozil 100 µM -1.04168716828099 0.167737851248088 no 2865 0.148778370023306 4057 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels.
SGTC_448 monastrol 171 µM -1.04312115622413 0.167400839348577 no 2866 0.148446091723986 4047 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity
SGTC_2029 5175081 200 µM -1.04324453249804 0.167371864194849 no 2867 0.148417526641876 4096 1380876
SGTC_1849 st056239 19.2 µM -1.04418843116291 0.167150294745224 no 2868 0.148199109170735 4143 5393181
SGTC_1160 4092-0570 10.5 µM -1.0494313132531 0.165923032215904 no 2869 0.146989826334468 4137 4994975
SGTC_104 0074-0074 590.992 µM -1.04997634715483 0.165795784794018 no 2870 0.146864493810098 3922 3943124
SGTC_255 tunicamycin 200.472 nM -1.05071764658676 0.165622817130382 no 2871 0.14669414439721 4070 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_103 0844-0104 51.839 µM -1.05223728279795 0.165268604809249 no 2872 0.146345349069008 4055 5375804
SGTC_1327 1436-0082 2.18 µM -1.05531084355463 0.164553687558812 no 2873 0.145641591702983 4156 15992205
SGTC_17 0960-0276 49.807 µM -1.05542882684051 0.16452628438012 no 2874 0.145614622335301 4124 6821114
SGTC_1484 3473-2379 286 µM -1.05624765994995 0.164336181058133 no 2875 0.145427540795897 4263 671917
SGTC_2958 9077254 16.72 µM -1.05629738828382 0.1643246405332 no 2876 0.145416184406673 4229 16457351
SGTC_2253 7938677 135.83 µM -1.05759821774989 0.164022941855405 no 2877 0.145119327704914 4217 2301972
SGTC_436 n,n-dimethylsphingosine 3.3 µM -1.05962023623878 0.163554693200113 no 2878 0.144658701774418 4249 5282309
SGTC_3024 9090631 49.47 µM -1.06088967070379 0.163261168067378 no 2879 0.144370022016656 4129 25236383
SGTC_1294 1000-1494 117 µM -1.06191808038387 0.163023625035422 no 2880 0.144136438130759 4152 712797 YDL207W GLE1
SGTC_34 0469-0683 81.75 µM -1.06387482039922 0.162572276131771 no 2881 0.143692705514511 4114 3690923
SGTC_1115 galangin 695.678 nM -1.0656358169401 0.162166773918662 no 2882 0.143294150842249 4223 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_3143 9086658 49.47 µM -1.06581875783844 0.162124686169233 no 2883 0.143252789888806 4207 25236626
SGTC_2192 5915882 198.485 µM -1.06900196387458 0.161393490262531 no 2884 0.142534392241724 4110 2876149
SGTC_771 0250-0039 27.3 µM -1.0697331313566 0.161225842197137 no 2885 0.14236972437091 4123 3005115
SGTC_707 0865-0008 204 µM -1.07078874892454 0.160984002042802 no 2886 0.14213221347958 4176 723043
SGTC_2979 9012552 45.46 µM -1.071615947375 0.160794657859669 no 2887 0.141946283738511 4189 17100905
SGTC_596 1155-0152 116 µM -1.07200283416487 0.160706150122712 no 2888 0.141859379578682 4163 280313
SGTC_1955 wogonin 32.4 µM -1.07250281226522 0.160591817722929 no 2889 0.141747125741751 4231 5281703 A flavanone.
SGTC_526 4469-0568 170 µM -1.07470671283002 0.160088474600988 no 2890 0.141253028690423 4114 2901964
SGTC_284 0988-0104 32.6 µM -1.0766659751101 0.159641870834193 no 2891 0.14081475909737 4153 4666532
SGTC_2162 5663267 200 µM -1.07850585135474 0.159223223539831 no 2892 0.140404035950339 4168 6456493
SGTC_2735 sertaconazole 140 nM -1.08053231167203 0.158762953594525 no 2893 0.139952603100309 4305 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C
SGTC_2206 7254556 146.969 µM -1.0816071076284 0.158519189512593 no 2894 0.139713572463578 4169 4398905
SGTC_254 nsc-64875 3.808 µM -1.08510155666963 0.157728344637963 no 2895 0.138938338981712 4180 56993
SGTC_2603 homopterocarpin 100 µM -1.08551177913358 0.157635675573651 no 2896 0.138847524769649 4163 101795 A weak amylase inhibitor.
SGTC_2438 5259590 200 µM -1.08591163898372 0.157545381851985 no 2897 0.138759043523516 4188 1201127
SGTC_68 0986-0284 82.829 µM -1.08680359626671 0.157344088408751 no 2898 0.138561809042778 4236 423278 YIL048W NEO1
SGTC_2245 6637752 200 µM -1.08851348937446 0.156958679311085 no 2899 0.138184242406272 4244 681890
SGTC_35 0133-0054 64.071 µM -1.09127363188457 0.156337855982717 no 2900 0.137576248334735 4195 99677
SGTC_663 1486-0733 13.9 µM -1.09226627047445 0.156114983331054 no 2901 0.137358040647829 4193 722445 YPR165W RHO1
SGTC_2316 5844804 197.44 µM -1.09257566184256 0.156045559905133 no 2902 0.137290076745041 4198 776813
SGTC_3149 9097855 49.47 µM -1.09316243665394 0.155913951110653 no 2903 0.137161243201609 4199 25236625 YMR079W SEC14
SGTC_1323 1348-1351 11.2 µM -1.09370067728627 0.155793292497121 no 2904 0.137043138572801 4136 6989654
SGTC_1178 0988-0033 191 µM -1.09631447416057 0.15520822744116 no 2905 0.136470588661851 4228 5392207
SGTC_3090 9117696 49.47 µM -1.10075271741505 0.15421810975855 no 2906 0.135502147702863 4161 7923821
SGTC_989 1501-0895 10.3 µM -1.10227345245029 0.153879815430636 no 2907 0.13517140358388 4168 2830112
SGTC_515 4092-1064 102 µM -1.10319841740176 0.153674293213493 no 2908 0.134970504231165 4223 717353
SGTC_3279 9140807 49.47 µM -1.10343209743434 0.153622399541853 no 2909 0.134919782117312 4247 45595718
SGTC_287 k060-0039 29.6 µM -1.10745185037941 0.152731543691206 no 2910 0.134049309449286 4244 5861974
SGTC_64 000l-0018 272.079 µM -1.10847395082457 0.152505573747061 no 2911 0.133828591501727 4122 6811119
SGTC_3006 9075424 71.4286 µM -1.10978745907956 0.15221550413516 no 2912 0.133545312320678 4166 7465181
SGTC_3089 9117425 49.47 µM -1.10989912601999 0.152190860985684 no 2913 0.133521248581845 4208 9401657
SGTC_2592 piperlongumine 83.33 µM -1.11103710157073 0.151939878614286 no 2914 0.133276189852474 4221 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_1191 1487-1166 10.6 µM -1.11202566625765 0.15172207235136 no 2915 0.133063557517443 4242 3955771
SGTC_106 0092-0003 11.579 µM -1.11280928516332 0.151549568424538 no 2916 0.132895173369302 4124 1072148
SGTC_1641 st009299 47.1 µM -1.11516291946932 0.151032229414777 no 2917 0.132390306418882 4136 4046054
SGTC_2942 9052777 62.25 µM -1.11551374435433 0.150955217347323 no 2918 0.13231516598108 4271 6469503
SGTC_1149 3909-7961 23.3 µM -1.11676867521996 0.150679952528228 no 2919 0.13204662282113 4247 735261
SGTC_709 3807-1509 243 µM -1.11762835744553 0.15049157718926 no 2920 0.131862876148865 4284 1886677 YPL242C IQG1
SGTC_2083 5306046 65.942 µM -1.11984639443717 0.150006281168477 no 2921 0.13138961246426 4214 539837
SGTC_1324 1418-0026 34.4 µM -1.1211959769428 0.149711510055757 no 2922 0.131102225909304 4245 1372513
SGTC_222 nsc-310342 10.666 µM -1.12421707383705 0.149053054218511 no 2923 0.130460473965142 4224 432556
SGTC_554 4483-2211 187 µM -1.12576031016476 0.148717449489584 no 2924 0.130133494060144 4272 747107
SGTC_3184 9108758 49.47 µM -1.12666850151107 0.148520183072247 no 2925 0.129941332376055 4243 902885
SGTC_2851 9015922 71.43 µM -1.1277532795694 0.148284790013747 no 2926 0.129712064754405 4248 2996893
SGTC_1084 voriconazole 435 nM -1.1280982951653 0.148209975172981 no 2927 0.129639204535301 4223 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_2009 4012297 12.05 µM -1.12901268327624 0.148011817038359 no 2928 0.129446241654962 4210 45595307
SGTC_1769 st044406 64.4 µM -1.12912467244197 0.147987559927824 no 2929 0.129422622322252 4194 670903
SGTC_1938 st074717 56.4 µM -1.13040119672097 0.147711249872413 no 2930 0.129153605046986 4118 17250979
SGTC_3044 9093193 49.47 µM -1.13105374015472 0.147570137121582 no 2931 0.129016236578023 4251 25236277
SGTC_2783 7738165 71.43 µM -1.13220705784107 0.147320952677686 no 2932 0.128773696779406 4209 17201110
SGTC_56 0957-0365 83.25 µM -1.13241888582676 0.147275216047215 no 2933 0.128729184295311 4193 6752360
SGTC_1652 st011932 78 µM -1.13559330478155 0.146590954491035 no 2934 0.128063406107996 4169 1551076
SGTC_2690 usnic acid 100 µM -1.13642369836735 0.146412311720196 no 2935 0.127889641143823 4258 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_378 3970-0959 8.33 µM -1.13681105746475 0.146329029076634 no 2936 0.12780863993326 4260 6615653
SGTC_1906 st060206 94.7 µM -1.13709954563289 0.146267024465262 no 2937 0.127748336932738 4249 5133468
SGTC_2981 9013952 38.96 µM -1.14476871837069 0.144625161515519 no 2938 0.126152488365024 4212 2996344
SGTC_471 1-acyl-paf 4 µM -1.14486906847329 0.144603760571406 no 2939 0.126131699418772 4172 16759367
SGTC_2774 tamoxifen 10.92 µM -1.14978345734747 0.143558314341503 no 2940 0.125116535175631 4220 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.
SGTC_1029 k015-0030 64.7 µM -1.15074597812716 0.143354154639946 no 2941 0.124918377575558 4282 2208316
SGTC_2491 paeonol 100 µM -1.15097652816248 0.143305281929841 no 2942 0.12487094598058 4179 11092 Increases levels of cortical cytochrome oxidase.
SGTC_1385 3091-4834 14.1 µM -1.15200807196652 0.143086749891683 no 2943 0.124658878183594 4212 4072814
SGTC_1900 st060200 72.8 µM -1.15413917686856 0.142635989729565 no 2944 0.124221556958006 4233 688945
SGTC_1953 st076800 12.1 µM -1.15471783622599 0.14251376066141 no 2945 0.124102996519709 4236 297591
SGTC_300 r073-0011 5.04 µM -1.15476152673981 0.142504534877907 no 2946 0.124094048067281 4234 2735780
SGTC_2077 5212015 200 µM -1.15505071924555 0.142443478547874 no 2947 0.124034828621282 4122 780900
SGTC_2864 9034755 47.6 µM -1.15556337276316 0.142335287069343 no 2948 0.123929898512496 4171 4930451
SGTC_637 1181-0519 7.26 µM -1.15808068926525 0.141804834173534 no 2949 0.123415554830836 4239 6252091 YGR060W ERG25
SGTC_2465 5809242 33.21 µM -1.15826643815929 0.141765745981862 no 2950 0.123377661535401 4292 2731748
SGTC_1763 st044482 94.5 µM -1.15907014254308 0.141596702017741 no 2951 0.123213797522833 4231 88505
SGTC_220 paclitaxel 373.376 µM -1.16179700373086 0.141024176509644 no 2952 0.122658965717702 4200 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_2092 5303694 80.6725 µM -1.16444275813518 0.140470182621483 no 2953 0.122122314080532 4243 1963699
SGTC_778 3456-2434 196 µM -1.16474287476093 0.140407434706508 no 2954 0.122061544192375 4208 5539063
SGTC_3056 9094900 49.47 µM -1.16527050734711 0.140297164259127 no 2955 0.121954756641189 4240 25236784
SGTC_980 1473-0395 201 µM -1.16896398362051 0.139526908081983 no 2956 0.121209071302388 4145 768876
SGTC_3102 9121669 49.47 µM -1.17000276691805 0.139310794154335 no 2957 0.120999927680535 4295 41905072
SGTC_1418 3966-3099 2.4 µM -1.17013293842072 0.139283728658956 no 2958 0.120973737490634 4255 740335
SGTC_1449 4112-4002 201 µM -1.172060310023 0.138883404720202 no 2959 0.120586421697862 4311 2059539
SGTC_3123 9126162 49.47 µM -1.17229744366396 0.138834205155353 no 2960 0.120538828793784 4315 25239884
SGTC_306 1672-3436 11.6 µM -1.17312269493712 0.138663077768181 no 2961 0.120373303347395 4293 6797378
SGTC_1022 4477-0945 21.3 µM -1.17410861380645 0.138458822157268 no 2962 0.120175761845473 4213 4648966
SGTC_1156 4092-0367 4.88 µM -1.1754701851236 0.138177078821624 no 2963 0.11990332927882 4288 1357585
SGTC_2248 tofa 1.1 µM -1.17585015465292 0.138098523387072 no 2964 0.119827380122921 4249 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_483 fpl-64176 144 µM -1.17722633638062 0.13781426457365 no 2965 0.119552589769741 4371 3423
SGTC_433 pimozide 108 µM -1.17847426772313 0.137556842040366 no 2966 0.119303792507162 4179 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic
SGTC_669 0108-0021 26.2 µM -1.18038161813997 0.137164029499424 no 2967 0.118924234767688 4237 17201
SGTC_1424 4048-1941 275 µM -1.18158649147423 0.13691628509156 no 2968 0.118684908072163 4345 X1424
SGTC_373 0844-0104 25.9 µM -1.18652997534003 0.135903015263827 no 2969 0.117706535526352 4286 5375804
SGTC_2633 5,7-dihydroxyisoflavone 100 µM -1.18681171684955 0.135845421542537 no 2970 0.117650948066294 4285 5377381
SGTC_132 0417-1715 25.805 µM -1.18798819269051 0.135605106471058 no 2971 0.117419030767493 4269 6769098
SGTC_2178 5812956 200 µM -1.19003673722984 0.135187352086266 no 2972 0.117015976562184 4248 5403383
SGTC_831 k061-1017 217 µM -1.19154394143838 0.134880555822332 no 2973 0.116720058562946 4317 1240153
SGTC_1670 st016595 4.04 µM -1.19299555680415 0.134585526706265 no 2974 0.116435556590334 4300 597879
SGTC_890 0929-0006 47.2 µM -1.19595068347731 0.13398629056054 no 2975 0.115857902401142 4266 1378169
SGTC_2580 diallyl disulphide 81.36 µM -1.19744049378179 0.133684885225128 no 2976 0.115567454151157 4259 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.
SGTC_279 1273-0055 2.93 µM -1.20277586741209 0.132609305039866 no 2977 0.114531532947694 4313 2847562
SGTC_3200 9114385 49.47 µM -1.21011073483314 0.131140393004837 no 2978 0.113118202265078 4294 17018030 YLR208W SEC13
SGTC_3245 9134821 49.47 µM -1.21251394740006 0.130661569128355 no 2979 0.112657853459023 4305 17014901
SGTC_2232 chlorophetanol 41.5365 µM -1.21344939134571 0.130475515451532 no 2980 0.112479026175476 4355 15907 An antifungal of unknown mechanism. YFR051C RET2
SGTC_3128 9127691 49.47 µM -1.21444446019028 0.130277803973359 no 2981 0.112289023179119 4326 41316314
SGTC_1585 2',4'-dihydroxychalcone 10.4 µM -1.21473199454707 0.13022071203121 no 2982 0.112234162791978 4287 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_3311 9131146 2.8755 µM -1.21544807454713 0.130078604625698 no 2983 0.112097620899302 4249 4900406 YPR165W RHO1
SGTC_1767 st044992 70.3 µM -1.21555493393358 0.130057407388961 no 2984 0.112077255174347 4343 9600693
SGTC_2271 7849410 118.62 µM -1.21863989218801 0.129446488101184 no 2985 0.111490450503746 4241 972430
SGTC_2743 auranofin 4.32 µM -1.21879826926824 0.129415178181375 no 2986 0.111460384287973 4320 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold.
SGTC_1142 3253-1408 9.78 µM -1.22111346320002 0.128958081304065 no 2987 0.111021531442517 4326 256655
SGTC_827 3253-0474 693 µM -1.22221279615998 0.128741428645984 no 2988 0.110813583043932 4336 5402065
SGTC_3281 9140613 49.47 µM -1.22243709889211 0.128697254892206 no 2989 0.110771188530601 4308 16013766
SGTC_3169 9102970 49.47 µM -1.22803917470252 0.127597402958564 no 2990 0.109716131222691 4375 17027839
SGTC_2270 7924575 90.91 µM -1.22966210525221 0.127279998430387 no 2991 0.109411831437689 4285 1262135
SGTC_3198 9112019 49.47 µM -1.23387311494404 0.12645899335772 no 2992 0.108625094560497 4356 45595555
SGTC_353 1988-1175 58.3 µM -1.23450382482017 0.126336344572203 no 2993 0.108507611182653 4156 2788357
SGTC_1116 jasmonic acid 1.58368 µM -1.2394612581078 0.125375200768314 no 2994 0.107587363817428 4367 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid.
SGTC_1961 st076550 68.7 µM -1.23953972756327 0.12536002831185 no 2995 0.107572842900192 4338 1579337
SGTC_2678 equilin 100 µM -1.24040168466509 0.125193449017737 no 2996 0.107413429104383 4305 3247 Equilin is an estrone commonly used hormone replacement therapy
SGTC_1816 st051957 91.6 µM -1.24260648704784 0.124768058925802 no 2997 0.107006439134802 4305 674121
SGTC_1689 st020265 53.493 µM -1.24283744078438 0.124723557696121 no 2998 0.106963871256265 4334 5758320 YPR016C TIF6
SGTC_1350 1495-0454 146 µM -1.24395597731247 0.124508189887167 no 2999 0.106757882776093 4358 1069057
SGTC_124 0136-0217 7.121 µM -1.24580621115029 0.124152508967636 no 3000 0.106417774377998 4378 3976905
SGTC_587 k089-0003 57 µM -1.24689289747755 0.123943940761455 no 3001 0.106218385681897 4241 9659696
SGTC_2352 9027995 87.8 µM -1.24997949741195 0.123352866082093 no 3002 0.105653518493797 4269 2997347
SGTC_1630 st005209 31.3 µM -1.25015984343 0.123318391526383 no 3003 0.105620581327158 4312 3367314
SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM -1.25165218158807 0.123033378426869 no 3004 0.105348315744783 4280 6708739 YPR165W RHO1
SGTC_2725 haloperidol 53.21 µM -1.25213343521398 0.122941565104178 no 3005 0.105260623094526 4273 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_2103 5378138 10 µM -1.25481569994672 0.122430724007976 no 3006 0.104772835936845 4404 244142
SGTC_1105 epirubicin 18.1 µM -1.25532808641464 0.122333308985216 no 3007 0.104679841664364 4354 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_2922 7999257 32.47 µM -1.25599336879206 0.1222069065563 no 3008 0.104559187160155 4298 2988377
SGTC_2464 5717415 7.67 µM -1.25701296101775 0.122013363903313 no 3009 0.104374471173574 4298 5285744
SGTC_2250 alverine citrate 130 µM -1.25964533738067 0.121514672441711 no 3010 0.103898666324786 4214 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1
SGTC_1056 3448-1962 115 µM -1.26566639627318 0.120379402086158 no 3011 0.102816271967066 4319 715507
SGTC_2928 9011484 9.79 µM -1.27142521397588 0.119300586720504 no 3012 0.101788708665907 4342 2994751
SGTC_882 0843-0131 351 µM -1.27306006198135 0.118995573347509 no 3013 0.101498364793702 4337 5425421
SGTC_2949 9072542 2.23 µM -1.2817283945414 0.11738752400122 no 3014 0.0999689703222224 4360 16457352
SGTC_2661 dactinomycin 12.96 µM -1.29808176419912 0.114395866001629 no 3015 0.097129619965261 4328 45006140 An Actinomycin D Classic transcription inhibitor.
SGTC_713 1488-1073 324 µM -1.30077811457199 0.113907859965754 no 3016 0.0966672076198596 4392 3312542
SGTC_1618 st003135 44.5 µM -1.30406518358157 0.113314949986198 no 3017 0.09610567926438 4335 1270615
SGTC_1199 1638-0010 4.46 µM -1.30438570476623 0.113257253512653 no 3018 0.0960510533802822 4347 3111136
SGTC_1640 st009078 66.4 µM -1.31156454278676 0.111970490588256 no 3019 0.0948335515670577 4349 690618
SGTC_2714 st079313 56.9 µM -1.31428707791955 0.111485237035904 no 3020 0.0943748070910435 4366 2939799
SGTC_2402 5553605 200 µM -1.31434250613872 0.111475373392377 no 3021 0.0943654845184865 4451 6758546
SGTC_718 1130-0073 349 µM -1.31828930338321 0.110774631909147 no 3022 0.0937034101646515 4392 6740020
SGTC_986 1493-0483 84 µM -1.320712490414 0.110345969527251 no 3023 0.0932986238752879 4327 40079
SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM -1.32312442731295 0.109920479796491 no 3024 0.0928970012766745 4382 115019
SGTC_314 1671-0008 2.74 µM -1.32371392562669 0.10981666569551 no 3025 0.0927990358939435 4266 3913060
SGTC_794 k038-0031 316 µM -1.33138823472952 0.108471592174908 no 3026 0.0915306493275127 4376 6624242
SGTC_245 methotrexate 289.6 µM -1.33532326048464 0.107786516709807 no 3027 0.0908852844233101 4348 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2
SGTC_219 mitoxanthrone 164.414 µM -1.33799745877032 0.107322729465969 no 3028 0.0904486325928871 4328 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA. YMR168C CEP3
SGTC_1519 esterone 74 µM -1.33808673056506 0.107307271877224 no 3029 0.0904340829167735 4362 698 A steroid.
SGTC_1060 3448-7350 82 µM -1.33971676201813 0.107025310854726 no 3030 0.0901687229680481 4324 570178
SGTC_408 cantharidin 100 µM -1.34037020170879 0.106912429766624 no 3031 0.0900625092304396 4362 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_910 3454-3003 490 µM -1.3415589037222 0.106707302912907 no 3032 0.0898695293776539 4300 820824
SGTC_2028 5153890 36.43 µM -1.34251846959263 0.106541923948429 no 3033 0.0897139729502234 4379 2830968 YPR165W RHO1
SGTC_622 1348-1566 26.3 µM -1.34998556440135 0.105261306666075 no 3034 0.0885103066893055 4387 7340407
SGTC_3088 9117578 49.47 µM -1.35102621208528 0.105083722102549 no 3035 0.0883435181133361 4460 678341
SGTC_1260 0700-1617 7.75 µM -1.35278010717198 0.10478491408987 no 3036 0.0880629448571414 4379 2853078
SGTC_147 4466-0538 29.23 µM -1.35299898554021 0.104747667394728 no 3037 0.0880279772338177 4476 6742687 YHR072W ERG7
SGTC_1714 st033236 13.627 µM -1.35355565725683 0.104652981357332 no 3038 0.0879390909883244 4421 2916566
SGTC_2187 6125751 200 µM -1.35371099537026 0.104626570477354 no 3039 0.0879142994104238 4424 874498
SGTC_1134 3477-0009 42.5 µM -1.35555745970268 0.104313000824044 no 3040 0.0876200073850326 4455 3973534
SGTC_1660 st012960 28.1 µM -1.35581705386739 0.104268970776115 no 3041 0.0875786919150117 4431 24207266
SGTC_2320 7373003 200 µM -1.35674442807774 0.104111787846539 no 3042 0.0874312152535719 4416 5415828
SGTC_629 3448-6466 76.7 µM -1.36244165792114 0.103149918747243 no 3043 0.0865292722434871 4421 573744
SGTC_2903 5923464 63.88 µM -1.36335713066473 0.102995962328118 no 3044 0.0863849924090152 4422 2876576
SGTC_1451 4152-0210 104 µM -1.36699494676045 0.102385834883483 no 3045 0.0858134447105799 4447 659563
SGTC_111 0083-0039 52.457 µM -1.37507124511356 0.10104069739657 no 3046 0.0845546790258118 4369 759313
SGTC_1283 0922-0125 16.4 µM -1.37593996457492 0.1008967798552 no 3047 0.0844201104529882 4416 3360884
SGTC_1869 3',7'-dimethoxyflavone 40.3 µM -1.38280257417264 0.0997651275734633 no 3048 0.0833627047418262 4467 688664
SGTC_36 0335-0881 14.2 µM -1.38713102273181 0.099056146304601 no 3049 0.0827009069072302 4321 23828853
SGTC_2191 5911152 200 µM -1.38755365105311 0.0989871195847381 no 3050 0.0826365016532361 4449 2875902
SGTC_3286 9117135 37.221 µM -1.38846254198187 0.0988387921510443 no 3051 0.0824981216763138 4384 3438150
SGTC_1853 st056710 91.2 µM -1.39078403637318 0.0984606717095525 no 3052 0.0821454626621878 4471 269167
SGTC_3025 9087895 49.47 µM -1.39314080069882 0.0980778911019954 no 3053 0.081788608601261 4393 17173641
SGTC_3165 9101544 49.47 µM -1.39324840347345 0.0980604405537533 no 3054 0.0817723436542586 4419 5002184
SGTC_1432 4049-0298 68.4 µM -1.3945785897719 0.0978449046123819 no 3055 0.0815714775769967 4444 741646
SGTC_2968 9090663 33.37 µM -1.4020449285064 0.0966415429685848 no 3056 0.0804509153502401 4383 25236811
SGTC_2496 diffractaic acid 79.83 µM -1.4083036575346 0.0956412185251959 no 3057 0.0795205865490723 4428 94870 An apoptosis inducer which activates caspases.
SGTC_1147 3809-1045 12.3 µM -1.4103978299153 0.0953082166877124 no 3058 0.0792111229117104 4440 325925
SGTC_2895 9054447 58.44 µM -1.41148383968698 0.0951358628811938 no 3059 0.0790509986748749 4507 2697450
SGTC_2642 cholecalciferol 100 µM -1.41153316929243 0.0951280395421585 no 3060 0.0790437312082959 4435 9821465 A vitamin D precursor, similar to steriods.
SGTC_705 1124-0212 310 µM -1.41307016512482 0.0948845197934277 no 3061 0.0788175472603658 4437 9554485
SGTC_2608 thymoquinone 42.66 µM -1.41724911880524 0.0942247340681946 no 3062 0.0782050527567019 4411 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC).
SGTC_3291 9121177 71.43 µM -1.41793709440402 0.0941164396336565 no 3063 0.0781045656177019 4435 17015612
SGTC_721 1187-1332 279 µM -1.41822878753429 0.0940705518656731 no 3064 0.0780619898957925 4431 25730
SGTC_1325 1431-0015 227 µM -1.41964365472664 0.0938482059390916 no 3065 0.0778557247410246 4462 1103340
SGTC_3062 9077494 49.47 µM -1.4198453809392 0.0938165363514676 no 3066 0.0778263499865162 4403 16459633
SGTC_1257 0669-0121 16 µM -1.42048900725046 0.0937155443145564 no 3067 0.0777326833226822 4439 4307855
SGTC_57 miconazole 162.5 nM -1.4226949963333 0.0933700093963429 no 3068 0.077412295882186 4280 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_327 1273-0057 3.96 µM -1.42337281437495 0.0932640286731817 no 3069 0.0773140544919923 4356 3108138
SGTC_2747 doxorubicin 7.63 µM -1.42519336948211 0.0929798144867985 no 3070 0.0770506562319908 4494 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_379 3970-0972 5.9 µM -1.42590916185209 0.0928682447864128 no 3071 0.0769472822379477 4445 2898042 YBL034C STU1
SGTC_1623 st003709 20.3 µM -1.4267408178816 0.0927387399075869 no 3072 0.0768273077718633 4421 16192618
SGTC_2817 7995342 71.43 µM -1.42692810608989 0.0927095939564331 no 3073 0.0768003092578334 4433 18879975
SGTC_2172 5754775 163.918 µM -1.42965916755177 0.0922853532082728 no 3074 0.0764074324643983 4442 2263357
SGTC_3221 9128209 49.47 µM -1.43095526796154 0.0920845215566645 no 3075 0.0762215178470146 4476 16460723
SGTC_1470 k295-0292 231 µM -1.43105514004004 0.0920690597474741 no 3076 0.0762072063432578 4517 5045612
SGTC_257 daunorubicin 18.5 µM -1.44890756493545 0.0893359999891656 no 3077 0.0736816991217648 4489 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_1854 st056233 32.9 µM -1.46008456421661 0.0876558906250911 no 3078 0.0721334171612415 4388 5393174
SGTC_1798 st045719 60.953 µM -1.46137086845876 0.0874640581933234 no 3079 0.0719568454179513 4428 3980186
SGTC_865 0488-0499 301 µM -1.46215128046065 0.0873478246034482 no 3080 0.0718498794460771 4417 9634651
SGTC_1179 1021-1431 9.29 µM -1.4663153852985 0.0867295764978615 no 3081 0.0712811929701408 4497 2840958
SGTC_1195 1502-0147 41.1 µM -1.47157989227554 0.0859526387836547 no 3082 0.0705671793773592 4480 817940
SGTC_716 1683-5115 658 µM -1.47372171308927 0.0856380429377363 no 3083 0.0702782671037088 4474 723597
SGTC_1274 0865-0114 173 µM -1.47421237487027 0.085566094867229 no 3084 0.0702122095023966 4469 870624
SGTC_2054 5233173 129 µM -1.47541138701056 0.0853904684775365 no 3085 0.0700509879089597 4480 6889
SGTC_1214 0358-0031 63.7 µM -1.47815732273899 0.0849892725445779 no 3086 0.0696828369741838 4498 4301366
SGTC_760 0568-0725 82.9 µM -1.4826081861537 0.0843419811929197 no 3087 0.0690892704577726 4495 3916171
SGTC_2873 9040596 71.43 µM -1.4875721786117 0.0836244368484417 no 3088 0.0684318775278458 4449 6463863
SGTC_165 k038-0023 64.381 µM -1.49650178589588 0.0823452250189246 no 3089 0.0672614714318237 4479 46368543
SGTC_1609 st001574 46.4 µM -1.49670919758945 0.082315688326862 no 3090 0.0672344709922609 4487 3960012
SGTC_2303 7774051 200 µM -1.49882097946949 0.0820154117012215 no 3091 0.0669600402482011 4485 2953184
SGTC_1466 k213-0079 57.5 µM -1.49980290408672 0.0818760721519485 no 3092 0.0668327324313763 4482 3657981
SGTC_3148 9097893 49.47 µM -1.50628720310488 0.0809603965325909 no 3093 0.0659967308921651 4469 17174100
SGTC_2217 6934799 96.0675 µM -1.51152669649157 0.0802261687876387 no 3094 0.0653271560638201 4480 675606
SGTC_580 1123-0028 41 µM -1.51231670332572 0.0801159004905471 no 3095 0.0652266568923739 4551 1677248 YPR107C YTH1
SGTC_3124 9127567 49.47 µM -1.5182661772499 0.0792891568250786 no 3096 0.0644736552699814 4453 17592030
SGTC_912 3474-0017 2.18 µM -1.51919153520974 0.079161150832655 no 3097 0.064357145691273 4511 3360550
SGTC_2268 7933382 153.85 µM -1.52070858251981 0.0789516343080758 no 3098 0.0641664919962737 4540 935025 YOR257W CDC31
SGTC_569 4130-2812 160 µM -1.52259552726046 0.0786916184342821 no 3099 0.0639299647436019 4378 743552
SGTC_3174 9107204 49.47 µM -1.52355419773958 0.0785597650880245 no 3100 0.0638100560692538 4509 3938802
SGTC_1715 st032160 10.2275 µM -1.5235560823449 0.0785595060487453 no 3101 0.0638098205188229 4411 5289825
SGTC_3159 9100096 49.47 µM -1.52552422962776 0.0782893371519363 no 3102 0.0635641974179987 4451 25236875
SGTC_1315 1237-0019 3.69 µM -1.52557939163172 0.0782817751901664 no 3103 0.0635573238613069 4508 825140
SGTC_2318 6029776 164 µM -1.52657564300904 0.078145297974866 no 3104 0.0634332837688111 4527 818325
SGTC_2079 5212404 121 µM -1.52758518467143 0.0780071843012957 no 3105 0.0633077812365927 4459 758462
SGTC_2156 5649887 115 µM -1.53763365381101 0.0766425502758907 no 3106 0.0620691070239799 4543 54680440 YKL052C | YBR257W ASK1 | POP4
SGTC_499 genistein 192 µM -1.5384483012751 0.0765327175911861 no 3107 0.0619695199934535 4607 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger.
SGTC_2466 5983409 37.09 µM -1.5441748421127 0.0757640281253953 no 3108 0.0612729908743677 4512 2879657
SGTC_1017 4239-0030 168 µM -1.55286711869961 0.0746084967853909 no 3109 0.0602274418422915 4529 1149593
SGTC_182 3448-4371 550.524 µM -1.5565996897527 0.0741164452816337 no 3110 0.0597827787604577 4456 3491403
SGTC_961 1252-1571 372 µM -1.56165269296166 0.0734542802605823 no 3111 0.0591849144700252 4547 6813498
SGTC_1103 duloxetine 36.1 µM -1.5619627728101 0.0734137940132291 no 3112 0.0591483795098487 4582 60835 A selective serotonin reuptake inhibitor.
SGTC_1973 st070275 50.2 µM -1.56359066860341 0.0732015242168726 no 3113 0.0589568638419173 4504 17118334
SGTC_1725 st036284 20.55 µM -1.56428021951499 0.0731117517990878 no 3114 0.058875887665609 4540 707914
SGTC_995 3931-2021 34.6 µM -1.56500723982268 0.0730171925155896 no 3115 0.0587906058790975 4537 730143
SGTC_812 4251-0442 148 µM -1.56515331040681 0.0729982052653947 no 3116 0.0587734830382861 4549 5723007
SGTC_2422 chlorphenesin carbamate 384.24 µM -1.56762412242375 0.0726776045791259 no 3117 0.0584844395490796 4481 2724 A muscle relaxant with antifungal properties.
SGTC_3220 9131269 49.47 µM -1.56804563956576 0.0726230183736126 no 3118 0.0584352407695806 4538 17722206
SGTC_958 1222-0007 33 µM -1.56838063111864 0.0725796595749135 no 3119 0.0583961642966363 4574 7312461
SGTC_561 1550-0330 72.9 µM -1.57153516983338 0.0721723316442499 no 3120 0.0580291959020355 4493 6812934
SGTC_667 1498-1044 59 µM -1.57449478366136 0.0717917685389964 no 3121 0.0576865532676915 4517 6739982
SGTC_2085 5307070 144.047 µM -1.57672641180087 0.0715058329965496 no 3122 0.0574292451927792 4482 2840351
SGTC_1208 2323-2347 50.3 µM -1.58123118666421 0.0709313057112736 no 3123 0.0569125935206836 4552 5412760
SGTC_1150 3909-7983 10.9 µM -1.58299539153144 0.0707072723185569 no 3124 0.0567112573907313 4540 23965914
SGTC_2176 5809774 33.9695 µM -1.59248281281455 0.0695117944343957 no 3125 0.0556381309573329 4463 2870539
SGTC_768 0384-0033 77.3 µM -1.5984596324625 0.0687667051484207 no 3126 0.054970361206261 4508 3965305 YMR134W ERG29
SGTC_1745 st081495 74 µM -1.60026551172656 0.0685427942080456 no 3127 0.0547698471723139 4402 13842402 YBL026W LSM2
SGTC_798 1287-0182 476 µM -1.60193140480504 0.0683367392243461 no 3128 0.0545853894752201 4587 1649755
SGTC_2287 7945887 168.79 µM -1.60530356863894 0.0679210983792168 no 3129 0.05421350710541 4557 1245853
SGTC_2750 bromebric acid 70.15 µM -1.60552293347006 0.0678941280302755 no 3130 0.0541893851640573 4538 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2
SGTC_2708 st078559 56 µM -1.6116506338126 0.0671440802459683 no 3131 0.0535189928792125 4512 17250902
SGTC_343 4130-2827 29.8 µM -1.6118713918165 0.0671171789016691 no 3132 0.0534949643513491 4532 1118244
SGTC_1741 st038134 10.228 µM -1.61556830493912 0.0666679143419124 no 3133 0.053093840608654 4566 1272587
SGTC_1666 st014829 29 µM -1.61993240326763 0.0661405699140887 no 3134 0.0526233991515013 4586 3858230
SGTC_1517 deoxycholic acid methyl ester 49.2 µM -1.62339913686928 0.0657239678921596 no 3135 0.052252054558929 4545 229346 A bile salt which induces apoptosis.
SGTC_1998 st075797 76.8 µM -1.62341280295594 0.0657223296548424 no 3136 0.0522505948233148 4544 24208315
SGTC_1603 st002045 67.8 µM -1.62581444311983 0.0654349216603693 no 3137 0.0519945674583283 4544 5887985
SGTC_704 1310-0270 142 µM -1.62837327651275 0.0651297757238299 no 3138 0.0517228802515099 4537 5718033
SGTC_2950 9072895 21.46 µM -1.62898879063855 0.0650565394670565 no 3139 0.051657695965106 4489 17332245
SGTC_2452 5863136 48.41 µM -1.6304867621318 0.064878572068041 no 3140 0.0514993303870105 4521 2184096
SGTC_1608 st001473 40.5 µM -1.63966859727485 0.0637959653522281 no 3141 0.0505370458280794 4526 7292267
SGTC_2442 5158906 48.48 µM -1.64006377367683 0.0637496884450836 no 3142 0.0504959538395107 4559 1893835
SGTC_1295 1013-0063 9.78 µM -1.64086758641831 0.0636556389957315 no 3143 0.0504124523874158 4563 6826038
SGTC_712 r015-0009 80.6 µM -1.64311068321458 0.0633937582195446 no 3144 0.0501800174489372 4595 6813872 YLR060W FRS1
SGTC_3215 9129942 49.47 µM -1.65245233798031 0.062312132986947 no 3145 0.0492211868313229 4531 17682944
SGTC_3310 9130229 44.1445 µM -1.65606436937087 0.0618977923934142 no 3146 0.0488543919939167 4580 7761258
SGTC_1401 3807-4679 7.6 µM -1.65629831833122 0.0618710301435334 no 3147 0.0488307104472713 4501 3291456
SGTC_3301 9125354 19.7965 µM -1.6581081031407 0.0616643075051051 no 3148 0.0486478243222174 4542 41905162
SGTC_1253 0550-0034 176 µM -1.65896790284036 0.0615662860530061 no 3149 0.0485611301362979 4565 5969915
SGTC_2830 7992007 71.43 µM -1.66316474668443 0.0610895704597938 no 3150 0.0481397311287354 4477 1952075
SGTC_1969 st069479 40.1 µM -1.66716463895697 0.0606379162664397 no 3151 0.0477408359671898 4567 3895485
SGTC_3108 9121785 49.47 µM -1.66864629394971 0.0604712773561211 no 3152 0.0475937492556034 4451 17140271
SGTC_1007 4101-0031 70 µM -1.66889815283108 0.0604429869328709 no 3153 0.0475687828775753 4568 1146276
SGTC_1728 st035614 33.7865 µM -1.6767566278989 0.0595654642047255 no 3154 0.0467950410900372 4529 15945546
SGTC_2911 7942208 15.64 µM -1.67884239658145 0.0593342400201021 no 3155 0.046591381701751 4576 1243384
SGTC_1719 st032227 49.2 µM -1.67924766204159 0.0592893948542095 no 3156 0.0465518932730957 4562 3125804
SGTC_1425 4048-4433 7.33 µM -1.68288918571369 0.0588876287939445 no 3157 0.0461982727331676 4653 23734946
SGTC_112 phenothiazine 287.218 µM -1.69241737295379 0.0578464974784829 no 3158 0.0452832110971871 4546 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.
SGTC_2155 5570423 76 µM -1.69408082536179 0.0576662271675314 no 3159 0.0451249627033167 4585 797402
SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM -1.69519617537826 0.0575456029829278 no 3160 0.0450191061093426 4550 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1
SGTC_1166 k206-0078 225 µM -1.69568107421838 0.0574932235086174 no 3161 0.044973147292381 4602 5404595
SGTC_283 0987-0079 11.7 µM -1.70039642357574 0.0569858182264287 no 3162 0.0445281920481211 4581 411556
SGTC_2173 5763948 167 µM -1.70102553936174 0.056918388284402 no 3163 0.0444690957729826 4560 2867177
SGTC_461 N-acetylfarnesylcysteine 136 µM -1.7030305072752 0.0567039107608734 no 3164 0.0442811797033938 4643 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ).
SGTC_570 0987-0065 62.6 µM -1.71172026600907 0.0557816912690676 no 3165 0.0434741160101096 4497 3104428
SGTC_1808 st050063 61.5 µM -1.71579888768264 0.0553529394820951 no 3166 0.0430994289201112 4551 4011993
SGTC_2881 9058953 51.95 µM -1.7193843620453 0.0549781814025278 no 3167 0.0427722038966119 4562 17122249
SGTC_2785 7756463 72.73 µM -1.72374529402853 0.0545250770442924 no 3168 0.0423769171803825 4569 2201551
SGTC_903 1134-0042 114 µM -1.72578045971459 0.0543146348687425 no 3169 0.0421934582500278 4613 701009
SGTC_1048 3161-0300 24.5 µM -1.72733334275885 0.0541544947785491 no 3170 0.0420539071545544 4610 2165101
SGTC_3309 9129340 25.759 µM -1.73123569986789 0.053753715797062 no 3171 0.0417048672384668 4580 17158987
SGTC_2647 atorvastatin 60.16 µM -1.73621173008298 0.0532460801417596 no 3172 0.0412632019705304 4595 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7
SGTC_170 4197-0004 226 µM -1.73929987074916 0.0529329556759533 no 3173 0.0409910150274206 4609 218692
SGTC_576 1073-0113 22.7 µM -1.74570004735963 0.0522886556077606 no 3174 0.0404315434351889 4654 5439563
SGTC_2571 chrysanthemic acid 100 µM -1.74690066395001 0.0521684871781242 no 3175 0.0403272853250295 4592 2743 An insecticide.
SGTC_849 0386-0493 241 µM -1.74821146759082 0.0520375408220831 no 3176 0.0402137083039377 4626 726119
SGTC_3 0833-0587 95.581 µM -1.74958596048262 0.0519005126520949 no 3177 0.0400948920269788 4511 5382644
SGTC_885 0865-0106 16.8 µM -1.75072885549554 0.0517867917788424 no 3178 0.0399963132583548 4573 2793380
SGTC_2125 5246583 200 µM -1.7577642777891 0.0510911056981617 no 3179 0.039393812913279 4607 835267
SGTC_1568 digitonin 820 nM -1.75950203514761 0.0509204209473081 no 3180 0.0392461374386676 4582 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1
SGTC_1376 2910-0861 41.3 µM -1.7630565670785 0.050572704302592 no 3181 0.0389454747941907 4559 1112859
SGTC_563 tetrahydrosecaminediol 614 µM -1.76426595960454 0.0504548295039048 no 3182 0.0388436061137209 4656 334274 A psychoactive constituent of the cannabis plant.
SGTC_2676 harmalol 100 µM -1.76457668102534 0.0504245800646258 no 3183 0.0388174687216568 4591 5459187 A monoamine oxidase inhibitor
SGTC_1171 0368-0077 21.4 µM -1.76541200174247 0.0503433313246106 no 3184 0.0387472738848052 4588 3239779
SGTC_2584 androsterone 48.74 µM -1.76647941111049 0.0502396600039323 no 3185 0.038657726377825 4504 2754130 A steroid.
SGTC_420 mitomycin C 81.9 mM -1.76873011061114 0.0500216202356369 no 3186 0.0384694624300043 4604 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_2557 derrustone 83.84 µM -1.77169924719933 0.0497351358811447 no 3187 0.0382222473506571 4589 629853 An antioxidant.
SGTC_530 4358-1714 28 µM -1.77977839690518 0.0489622231296567 no 3188 0.03755611721361 4605 1564641
SGTC_856 0433-0016 11.3 µM -1.77985271559796 0.0489551580418454 no 3189 0.0375500338834764 4641 3911780
SGTC_2759 disulfiram 3.38 µM -1.78078185750316 0.0488668981308401 no 3190 0.0374740471928152 4523 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_2075 5212009 200 µM -1.78302724766176 0.0486541316719697 no 3191 0.0372909339853527 4573 780898
SGTC_1433 4060-0023 7.6 µM -1.78468178527301 0.0484978270336823 no 3192 0.0371564735348448 4641 3840627
SGTC_940 3232-1287 54.8 µM -1.78957564079925 0.0480378523987054 no 3193 0.0367610786948614 4609 1585493 YIL048W NEO1
SGTC_525 k781-2675 26.7 µM -1.79024982249828 0.0479747604322613 no 3194 0.0367068794284893 4571 3651118 YDL195W SEC31
SGTC_769 0302-0231 76 µM -1.80173910124532 0.0469097212965637 no 3195 0.0357932315436566 4560 571869 YER009W NTF2
SGTC_1787 fluconazole 80 µM -1.80402960540692 0.0466996790607846 no 3196 0.0356133329734485 4266 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C
SGTC_567 1080-0542 68.4 µM -1.80845005052339 0.0462964521276159 no 3197 0.0352682420854197 4537 5950415
SGTC_1482 3346-2049 8.48 µM -1.82305059064732 0.044984441578036 no 3198 0.0341478644777826 4658 3826804
SGTC_625 k213-0058 121 µM -1.83160630113927 0.0442296356172309 no 3199 0.0335050486804886 4681 3655420
SGTC_2779 methotrexate 400 µM -1.83226041078656 0.0441723510649158 no 3200 0.0334563161593564 4613 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2
SGTC_2118 5526350 200 µM -1.83887396661101 0.0435965131804342 no 3201 0.0329668628529397 4630 743594
SGTC_839 0122-0028 230 µM -1.84973241228344 0.042664227740069 no 3202 0.0321760632444079 4660 759448
SGTC_1235 benzylparaben 21.5 µM -1.85090412867031 0.0425645971805128 no 3203 0.0320916733462357 4681 7180
SGTC_611 3453-1652 23.7 µM -1.85101688481249 0.0425550195038982 no 3204 0.0320835620188913 4639 1560575
SGTC_2145 5634607 200 µM -1.85197073424644 0.0424740678044502 no 3205 0.032015012750836 4651 308662
SGTC_2479 5617353 43.85 µM -1.85303707261984 0.0423837168348472 no 3206 0.031938522583295 4634 2731746
SGTC_372 0155-0182 15.9 µM -1.85392433180376 0.0423086578166334 no 3207 0.0318749931488915 4526 771486
SGTC_951 1171-0579 82.7 µM -1.85671643970599 0.0420731567106182 no 3208 0.0316757536718846 4568 1616050 YPR165W | YDR526C RHO1 | YDR526C
SGTC_210 3551-0445 56.827 µM -1.8599110789 0.0418050066431133 no 3209 0.0314490538145617 4616 2865180 YOR207C RET1
SGTC_2337 9009472 200 µM -1.86265854436049 0.041575499698272 no 3210 0.0312551609461503 4600 5742383
SGTC_78 0336-0123 156.75 µM -1.86903124284221 0.0410470910205042 no 3211 0.0308092339002215 4533 6765896
SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM -1.87017709571854 0.0409526598745543 no 3212 0.0307296146231907 4637 16623 A steroid.
SGTC_2357 9067248 200 µM -1.88121964167063 0.0400516331109196 no 3213 0.0299710234595775 4604 9150235
SGTC_829 1635-0120 117 µM -1.88749795276277 0.0395465736472094 no 3214 0.0295466907216289 4632 285054
SGTC_3225 9130819 49.47 µM -1.89084103298805 0.0392797600083006 no 3215 0.0293227839290251 4619 4547121
SGTC_753 1322-0200 289 µM -1.89144049652932 0.0392320716357227 no 3216 0.0292827835085197 4697 5403907
SGTC_2668 2',4'-dihydroxychalcone 15.08 µM -1.89774726750954 0.0387332071247987 no 3217 0.0288646913582303 4702 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_2644 guaiazulene 100 µM -1.90391490854665 0.0382503577400688 no 3218 0.028460633568368 4690 3515 A coloring agent.
SGTC_2991 9074669 71.4286 µM -1.91060476550428 0.0377321862049829 no 3219 0.0280276957488766 4596 17333109
SGTC_2934 9036370 36.88 µM -1.91162749957683 0.0376534762972165 no 3220 0.0279619947630796 4622 6462800
SGTC_2766 oltipraz 83.91 µM -1.91698303938848 0.0372434983627896 no 3221 0.0276200431989355 4638 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40
SGTC_1414 3917-0015 5.4 µM -1.92814070637755 0.0364010672850979 no 3222 0.0269188134779178 4675 6618702
SGTC_304 1310-0298 97 µM -1.93088650965343 0.0361961612698614 no 3223 0.0267485444192467 4414 1550234
SGTC_1222 0366-0074 1.18 µM -1.93184242822478 0.036125047687314 no 3224 0.0266894787449918 4678 286520
SGTC_568 1193-0097 7.48 µM -1.94215210106827 0.0353653279202209 no 3225 0.0260593448696998 4479 3646150
SGTC_118 0083-0097 135.343 µM -1.94689595423519 0.035020181485541 no 3226 0.0257736048954159 4641 5207356
SGTC_1216 1165-0504 9.65 µM -1.95360867707507 0.0345365150136193 no 3227 0.0253737568377745 4696 6304004
SGTC_2 0422-0095 29 µM -1.96077803809673 0.0340260207884002 no 3228 0.024952460523382 4610 6790840
SGTC_99 0109-0120 622.8 µM -1.96661679150945 0.0336148715501311 no 3229 0.0246137030777666 4676 759414
SGTC_1475 4092-1048 11.7 µM -1.97013218627387 0.0333693050459488 no 3230 0.0244116114920849 4674 2881759
SGTC_94 0334-0113 514.748 µM -1.97187738273681 0.0332479448501853 no 3231 0.0243118028955595 4679 6795178
SGTC_2855 9016525 58.44 µM -1.97187738409043 0.0332479447561967 no 3232 0.0243118028182788 4627 43811474
SGTC_2619 obliquin 87.91 µM -1.98271901721992 0.0325021417718243 no 3233 0.0236994120731145 4654 6708593 A bioactive alkalod. YER133W GLC7
SGTC_3188 9110789 49.47 µM -1.98443577914337 0.0323853199894255 no 3234 0.0236036403598522 4652 849217
SGTC_2031 5180455 200 µM -2.00014156312131 0.0313325783388086 no 3235 0.022742489900346 4688 29949
SGTC_1225 1216-0074 20.6 µM -2.00772249647089 0.0308346544201423 no 3236 0.0223363943398832 4683 4241466
SGTC_3154 9100113 49.47 µM -2.00883084741711 0.0307624085483474 no 3237 0.0222775378219775 4655 25237525
SGTC_2290 7904846 200 µM -2.00990993702754 0.0306922047227397 no 3238 0.022220360923792 4703 2962154
SGTC_2090 5301565 104.445 µM -2.01542640896456 0.0303353815696817 no 3239 0.0219299948236852 4699 2056344
SGTC_211 3455-0679 143.504 µM -2.02933243181429 0.0294511269463643 no 3240 0.0212122210595252 4653 748649
SGTC_2641 levomentholum 100 µM -2.03161282119716 0.0293081844333237 no 3241 0.0210964338519253 4703 16666
SGTC_2498 4'-Methoxychalcone 54.63 µM -2.03806393195106 0.0289069245253014 no 3242 0.0207717698172767 4685 641818 YHR062C RPP1
SGTC_636 0kpi-0074 126 µM -2.04058880410304 0.0287511254595711 no 3243 0.0206458579752338 4709 616434
SGTC_158 k038-0087 26.446 µM -2.04563165948053 0.0284420418639456 no 3244 0.0203963120756743 4615 X158
SGTC_464 bw-b 70c 158 µM -2.05945194544954 0.0276091197595169 no 3245 0.0197254819761346 4685 5353454
SGTC_1648 st011736 69.8 µM -2.06008717915911 0.0275713294010518 no 3246 0.0196951036568011 4688 2855514
SGTC_2293 7624732 200 µM -2.0628249032845 0.0274089539043841 no 3247 0.0195646335387941 4596 894453
SGTC_1031 k035-0009 16 µM -2.08281974341616 0.0262470732403208 no 3248 0.018633828622199 4724 5180959
SGTC_67 0335-0847 266 µM -2.08639098487492 0.0260439482724164 no 3249 0.0184716104705592 4668 4552207 YOR254C SEC63
SGTC_2331 7980721 200 µM -2.11113411640856 0.0246724272932525 no 3250 0.0173803928770732 4670 2981221
SGTC_3031 9088762 49.47 µM -2.11130547537174 0.0246631442923298 no 3251 0.0173730318644063 4707 205253
SGTC_1554 st069299 38.7 µM -2.11979762248972 0.0242067581078055 no 3252 0.0170115579501831 4678 24207999
SGTC_988 1497-1057 103 µM -2.12778836833464 0.023783816426814 no 3253 0.0166773170989942 4710 3533044
SGTC_3247 9135149 49.47 µM -2.14897661189083 0.0226923231238299 no 3254 0.0158181269872724 4723 8934436 YOR116C RPO31
SGTC_883 0850-0245 24.6 µM -2.15445447827809 0.0224171053465278 no 3255 0.0156022741059902 4732 6823229 YPR165W RHO1
SGTC_2010 4012422 159 µM -2.15918229373258 0.0221818399565343 no 3256 0.0154180135872975 4682 952393
SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM -2.15922685764366 0.0221796323194004 no 3257 0.0154162856927722 4738 688788
SGTC_1959 st077091 55.8 µM -2.15925058151034 0.0221784571460923 no 3258 0.0154153659055195 4702 821356 YKL052C ASK1
SGTC_200 k038-0079 37.545 µM -2.16375621889556 0.0219562188126238 no 3259 0.0152415319191691 4730 3436683
SGTC_2665 lovastatin 100 µM -2.16639960412369 0.0218267124314413 no 3260 0.0151403320952362 4737 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1
SGTC_404 fumagillin 50 µM -2.17247980929116 0.0215312741331267 no 3261 0.0149097454773044 4721 12015870 A methionine aminopeptidase binder.
SGTC_2890 9046729 58.44 µM -2.17402439163553 0.0214567632434157 no 3262 0.0148516517138616 4709 903329
SGTC_1044 1222-0021 1.78 µM -2.17973377528786 0.0211832308942475 no 3263 0.0146386007023113 4660 4306703
SGTC_745 0469-0705 296 µM -2.18350373475771 0.0210042364804232 no 3264 0.0144993671122558 4741 3486736
SGTC_2447 5741742 33.78 µM -2.18449488126637 0.0209573907492096 no 3265 0.0144629515034884 4747 1776504
SGTC_2296 7971656 126.45 µM -2.18536421773116 0.0209163750929555 no 3266 0.014431076144876 4697 666570
SGTC_1909 st060837 51.5 µM -2.20060371224376 0.020208331722747 no 3267 0.0138820452847679 4681 678937
SGTC_28 pentachloropyridine N-oxide 1.606 µM -2.20065488903245 0.0202059886646199 no 3268 0.0138802323211013 4733 140250 A respiratory chain inhibitor.
SGTC_3232 9132874 49.47 µM -2.20229788903056 0.0201308885072921 no 3269 0.0138221366083316 4711 3784940
SGTC_591 4299-0174 154 µM -2.20972475660521 0.0197943593916392 no 3270 0.0135621352560695 4755 5509088
SGTC_550 4123-0385 25.7 µM -2.21775044428611 0.0194360763730605 no 3271 0.0132859263486982 4733 5731123
SGTC_2383 9036125 200 µM -2.22448172416034 0.0191398407459345 no 3272 0.013058025390235 4711 79580
SGTC_2900 5328528 85.29 µM -2.23023203578628 0.0188898250280947 no 3273 0.0128660212535598 4695 795359
SGTC_2089 5281248 129.67 µM -2.23355227250873 0.0187467348763398 no 3274 0.0127562736338977 4721 2737878
SGTC_101 0490-5701 117.494 µM -2.23604819905952 0.0186397777692727 no 3275 0.0126743070411318 4656 4661669
SGTC_1945 st075991 56.6 µM -2.24667896217742 0.0181900204742605 no 3276 0.0123302758513098 4716 1084980
SGTC_3050 9093513 49.47 µM -2.24888712068354 0.018097768711566 no 3277 0.012259839309981 4702 25236664
SGTC_2985 9022375 71.43 µM -2.24900836486415 0.0180927149806743 no 3278 0.0122559819422026 4704 4939335
SGTC_2451 5856223 45.7 µM -2.25703539590686 0.017760795921813 no 3279 0.0120029315573303 4711 2179896
SGTC_2200 6600604 21.907 µM -2.25721022728742 0.0177536248109746 no 3280 0.0119974708313276 4746 2904777
SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM -2.25994140347499 0.0176419196692073 no 3281 0.0119124439023448 4762 279621
SGTC_2889 9059656 51.95 µM -2.27617813030747 0.0169901465322548 no 3282 0.0114176751543336 4752 3949838
SGTC_1245 0418-0076 17.2 µM -2.27708006694235 0.0169545526469191 no 3283 0.0113907223903916 4718 6790114
SGTC_1054 3429-0080 167 µM -2.29253634550974 0.0163544249720708 no 3284 0.0109373563727281 4724 1162877
SGTC_2622 2-methoxyxanthone 59.94 µM -2.29796351413648 0.0161480617608907 no 3285 0.0107819329067672 4721 71034 A hepatoprotective.
SGTC_1085 doxorubicin 7.67 µM -2.29943834253989 0.0160923697666343 no 3286 0.0107400303937607 4752 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_594 1487-1584 10.8 µM -2.30003136829619 0.0160700225623647 no 3287 0.0107232214828189 4736 5013332
SGTC_1317 1273-0028 910 nM -2.30503560239896 0.0158825030909613 no 3288 0.0105822897817672 4739 5917803 YLR359W | YHR072W ADE13 | ERG7
SGTC_123 0083-0120 66.675 µM -2.3134449765764 0.0155716107476515 no 3289 0.0103490933363371 4721 16001701
SGTC_608 k048-0125 159 µM -2.32341384961232 0.0152098425054717 no 3290 0.0100784654045025 4756 6817652 YLR060W | YFL022C FRS1 | FRS2
SGTC_1588 farnesol 29.9 µM -2.33494224890336 0.0148005042401798 no 3291 0.00977321893341604 4752 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_2081 5214970 32.255 µM -2.3390629149804 0.0146565083112363 no 3292 0.00966608881155315 4722 2063512
SGTC_1373 2887-0003 58.5 µM -2.34609164178686 0.0144136716504549 no 3293 0.00948572113561651 4714 776948
SGTC_2157 5649910 96.377 µM -2.3520727982965 0.014209763639905 no 3294 0.00933456039352197 4731 2858091
SGTC_1490 4089-0339 670 nM -2.35230418206178 0.0142019255470941 no 3295 0.00932875525322085 4751 742542
SGTC_392 N-ethylmaleimide 8.33 µM -2.37035598463441 0.0136017942512785 no 3296 0.0088854828271157 4737 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides.
SGTC_2869 9037858 32.47 µM -2.37350058953504 0.0134995217681084 no 3297 0.00881018246025714 4729 27187042
SGTC_1597 7-benzyloxygramine 47.5 µM -2.37750533696239 0.0133702363097692 no 3298 0.00871509537121095 4661 260807
SGTC_2110 5483698 200 µM -2.37989112049367 0.01329372530943 no 3299 0.00865887704381988 4739 2848765 YHR062C RPP1
SGTC_142 0335-0849 62.6745 µM -2.38270455957375 0.0132039858101219 no 3300 0.00859299037073824 4704 3889043 YPR107C YTH1
SGTC_141 0443-0274 32.331 µM -2.39163179776542 0.012922692961167 no 3301 0.00838683018539955 4705 1627241
SGTC_1113 artemisinin 1.17947 µM -2.3987711368394 0.0127014796383227 no 3302 0.00822509635255928 4760 2240 An anti-malaria and mitochondrial poison.
SGTC_2370 9071495 200 µM -2.40548585737023 0.0124964210382062 no 3303 0.00807548854414557 4761 21791103
SGTC_3131 9127911 49.47 µM -2.42173488417743 0.0120120212642966 no 3304 0.00772330751224907 4726 45595681
SGTC_1052 3253-3998 198 µM -2.45661649915297 0.0110268665085053 no 3305 0.00701261595774447 4736 5450317
SGTC_2805 7950783 58.44 µM -2.45682213849175 0.0110212735617425 no 3306 0.00700860331355966 4733 1178958 YDL195W SEC31
SGTC_3072 9116419 49.47 µM -2.46149417214887 0.0108948675660261 no 3307 0.00691798227774562 4744 17170162
SGTC_2073 5212005 126 µM -2.47541839657303 0.0105255899125899 no 3308 0.00665400850177894 4739 691789
SGTC_859 0439-0102 54.6 µM -2.4999848172754 0.0099006212822106 no 3309 0.00620993145818591 4770 610143
SGTC_2274 7947094 46.08 µM -2.5194706788274 0.0094281900958452 no 3310 0.00587657143987152 4739 2971028
SGTC_1729 st035615 45.989 µM -2.52210312630993 0.00936590308893315 no 3311 0.00583277515458882 4737 17385451
SGTC_2151 5563267 85.4165 µM -2.52679405246792 0.00925580177915519 no 3312 0.00575544906807584 4779 5310824
SGTC_1785 bathophenanthroline 24 µM -2.54683901329193 0.00879798628109088 no 3313 0.00543517840145609 4715 72812 An iron chelator.
SGTC_1987 st072290 61.9 µM -2.5614005674461 0.00847797450813794 no 3314 0.00521255392910205 4771 54697379
SGTC_3067 9117431 49.47 µM -2.57077183182232 0.00827747102491674 no 3315 0.00507360783921264 4761 17150885
SGTC_3017 9080681 49.47 µM -2.59480104448138 0.00778226591485985 no 3316 0.00473228438973907 4765 16451914
SGTC_2394 5221648 200 µM -2.59530856559653 0.00777209401526296 no 3317 0.0047253016236645 4760 788586
SGTC_659 k018-0002 107 µM -2.60630232842715 0.00755460670598508 no 3318 0.00457628179377848 4762 6797879 YHR007C ERG11
SGTC_299 1273-0059 1.44 µM -2.61548249928757 0.0073771223861255 no 3319 0.00445507436208306 4588 2848077
SGTC_1596 piperlongumine 63 µM -2.62090435575315 0.00727403432594583 no 3320 0.00438484308295766 4780 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_993 3909-8757 62.7 µM -2.6250280995638 0.00719648033616932 no 3321 0.00433209083224611 4753 4288324 YLR208W SEC13
SGTC_2683 piperine 63.03 µM -2.63576909212104 0.00699789125218675 no 3322 0.00419734176152283 4788 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_644 1498-1197 63.3 µM -2.66617429178764 0.00646171772707681 no 3323 0.00383599534989986 4789 6741615
SGTC_29 0299-0004 12.984 µM -2.69239504479988 0.00602886101117193 no 3324 0.0035470430100941 4747 16871 A napthoquinone isolated from Swertia calycina.
SGTC_177 1327-0068 8.361 µM -2.74550465977793 0.00523009520148211 no 3325 0.00302089547257196 4782 15389900 YOR207C | YLR033W RET1 | RSC58
SGTC_2907 7721985 69.9 µM -2.7520004933666 0.005139164124926 no 3326 0.00296162158331219 4764 3267881
SGTC_63 0099-0242 26.702 µM -2.77747607677296 0.00479598054023252 no 3327 0.00273914363658227 4776 3898502 YLR359W ADE13
SGTC_514 4466-0038 2.65 nM -2.7861424714091 0.0046839809745441 no 3328 0.00266697112299432 4678 5722064
SGTC_2767 sibutramine 71.45 µM -2.85242193795526 0.00390177728021817 no 3329 0.00216937337232612 4778 64765 A serotonin-norepinephrine reuptake inhibitor.
SGTC_137 0438-0332 85.389 µM -2.8698579703221 0.00371648110327921 no 3330 0.00205328105152777 4740 2063393 YER012W | YPR107C PRE1 | YTH1
SGTC_3294 9122953 26.2835 µM -2.87194670175319 0.0036948216007024 no 3331 0.00203975882336927 4773 16459826
SGTC_1994 st072947 40.9 µM -2.88711298572204 0.00354091815656045 no 3332 0.0019439729349868 4791 5286565 YDL195W SEC31
SGTC_456 gingerol 170 µM -2.8925122268886 0.00348753320763283 no 3333 0.00191087153278999 4776 442793 A herb.
SGTC_897 1000-0139 31.4 µM -2.9302835275241 0.00313384950340863 no 3334 0.00169326427532097 4776 6151020
SGTC_609 0986-0026 86.3 µM -2.96161654862141 0.00286532361561324 no 3335 0.00153014323057204 4777 2848610
SGTC_2042 p-Dimethylaminoacetophenone 200 µM -3.00109879428063 0.00255657894704919 no 3336 0.00134503636028881 4784 75037 A free radical scavenger.
SGTC_1177 0983-0204 23.6 µM -3.09538788684081 0.00193726805809755 no 3337 0.000982778323718532 4798 766818
SGTC_2299 7976368 114.88 µM -3.1061800988562 0.0018758616489111 no 3338 0.000947606242095296 4782 2979718
SGTC_2281 7943571 200 µM -3.13461042140074 0.00172247216170736 no 3339 0.000860412379855571 4795 1244024
SGTC_1489 4065-0444 182 µM -3.14158586876816 0.00168662517853668 no 3340 0.000840177635117051 4802 2877968
SGTC_116 0155-0182 31.788 µM -3.15138911189623 0.00163739378736911 no 3341 0.000812479256321448 4768 771486
SGTC_824 1304-0008 100 µM -3.18234107829968 0.00149042300218337 no 3342 0.000730448325084749 4794 768245
SGTC_2975 9084847 53.72 µM -3.19024505219857 0.001454873479834 no 3343 0.000710761010884353 4782 27211724
SGTC_2112 5488546 200 µM -3.30609614329945 0.00101533616364611 no 3344 0.00047302810061522 4788 600757
SGTC_2831 7999036 19.48 µM -3.5432856043163 0.000469754906461462 yes 3345 0.000197587240384924 4790 2988270
SGTC_363 0455-0021 3.06 µM -3.54701893502286 0.00046391872587574 yes 3346 0.000194808293764759 4785 4597466
SGTC_3304 9125678 46.087 µM -3.5943508108191 0.000395524832017144 yes 3347 0.000162600710852167 4800 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2
SGTC_2832 7992762 51.95 µM -3.60982966733234 0.000375272624197637 yes 3348 0.000153199069918557 4777 2985177
SGTC_1743 st037606 46.3785 µM -3.63375072463586 0.000345860657517139 yes 3349 0.000139665372977995 4795 590142 YLR208W | YDL195W SEC13 | SEC31
SGTC_2930 9013230 14.89 µM -3.66249853896787 0.00031335133909357 yes 3350 0.000124883588850243 4788 2995857
SGTC_2434 5670830 169.91 µM -3.86914308080108 0.000151053282401735 yes 3351 5.46092687754165e-05 4806 1549830
SGTC_600 1495-0418 41.6 µM -3.95260463101048 0.000111371100523792 yes 3352 3.86525542954243e-05 4809 5377768
SGTC_1920 st075728 45.7 µM -4.01716396796411 8.76322486692138e-05 yes 3353 2.94513704794232e-05 4806 3400306
SGTC_310 1273-0058 1.06 µM -4.94126707662365 1.93305754331799e-06 yes 3354 3.88082508231067e-07 4702 2734232
SGTC_1713 st033146 12.748 µM -5.0758536293106 1.04454708285416e-06 yes 3355 1.92880088072611e-07 4806 674619
SGTC_58 0957-0393 9 µM -6.48427879278795 6.60547292119399e-10 yes 3356 4.45786134146533e-11 4737 6997992