SGTCid condition conc unit YGR201C|YGR201C.score YGR201C|YGR201C.strain.pval YGR201C|YGR201C.strain.significant YGR201C|YGR201C.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene
SGTC_453 enantio-paf c16 10 µM 4.31099606124849 1.07259794387698e-06 yes 1 8.12604004163078e-06 119 13871343 A lipid and platelet activating factor
SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM 4.20748742188322 1.86873554875797e-06 yes 2 1.29112885713278e-05 18 688761
SGTC_1563 conessine 56.1 µM 4.07256216088896 3.78194477876109e-06 yes 3 2.32493924079086e-05 11 441082 An anti-amoebic, histamine inhibitor.
SGTC_2419 paclitaxel 166.5 µM 3.94703889728543 7.15001224627528e-06 yes 4 3.95618530551903e-05 41 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_1569 carminic acid 40.6 µM 3.91137513899833 8.53975539143818e-06 yes 5 4.5886048810539e-05 15 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_2468 5987765 72.9 µM 3.71815394962991 2.17903548102673e-05 yes 6 0.000100341981218377 21 26772094
SGTC_1587 estradiol valerate 56.1 µM 3.67085137905122 2.72273408379977e-05 yes 7 0.000120871941747385 17 13791 A steroid.
SGTC_2514 salinomycin 42.74 µM 3.61776494358763 3.48530987345756e-05 yes 8 0.000148579040504983 65 23682228 A polyether potassium ionophore.
SGTC_2206 7254556 146.969 µM 3.52245075404462 5.38572266858174e-05 yes 9 0.00021378823580942 6 4398905
SGTC_2917 7979103 53.79 µM 3.51538956431787 5.5598805823053e-05 yes 10 0.000219554672916701 45 2980565
SGTC_1572 epiandrosterone 68.9 µM 3.40975664411401 8.88920242271471e-05 yes 11 0.000325104346872431 44 441302 A steroid.
SGTC_2975 9084847 53.72 µM 3.39315270535549 9.55853542434759e-05 yes 12 0.00034546554726583 46 27211724
SGTC_1418 3966-3099 2.4 µM 3.31931548380249 0.000131503606974202 yes 13 0.000451192091287412 45 740335
SGTC_1924 st058459 75.1 µM 3.23657541257959 0.000186626267953426 yes 14 0.000604866287490342 28 688683
SGTC_1584 6-fluoro-dl-tryptophan 90 µM 3.2348239601532 0.000187998498565896 yes 15 0.000608588756378036 40 94937 An inhibitor of serotonin biosynthesis.
SGTC_1477 0139-0234 16 µM 3.17171644786624 0.000244218840352783 yes 16 0.00075770445826899 27 620880
SGTC_494 Boc-Gly-Val-Val-CHO 140 µM 3.14813417386601 0.000268988152596735 yes 17 0.000821581261308881 26 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA.
SGTC_2978 9011784 42.97 µM 3.10415584342727 0.000321542571824143 yes 18 0.000954113942154594 74 2994934
SGTC_3324 9138759 60.749 µM 3.09559762008662 0.000332820496028698 yes 19 0.000982083529625017 49 45595710
SGTC_3025 9087895 49.47 µM 3.04441545016469 0.000408312654381942 yes 20 0.00116566475255392 69 17173641
SGTC_2877 9040724 71.43 µM 3.0412157615974 0.000413523560212533 yes 21 0.00117812458848302 48 6463895
SGTC_1658 st012944 20 µM 3.01025307207852 0.000467233310884246 yes 22 0.00130515048815232 113 24207260
SGTC_2427 5545055 42.75 µM 3.00951157679307 0.00046859543959871 yes 23 0.00130834053196594 58 5372858
SGTC_1125 tnp00248 1.32998 µM 3.00743200482776 0.000472435270550774 yes 24 0.00131732528492526 98 24207736
SGTC_2963 9082507 9 µM 2.97023214865139 0.000546239670922736 yes 25 0.00148787390091942 72 16459611
SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM 2.94208075030836 0.000609028760359009 yes 26 0.0016300745123472 64 5024745
SGTC_536 3852-0578 10.6 µM 2.90772172696703 0.0006946801179492 yes 27 0.00182036073365404 71 2869208
SGTC_2297 7971671 152.32 µM 2.89321200925103 0.000734080856668056 yes 28 0.00190661903988885 69 909016
SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM 2.88649308046774 0.00075301474691225 yes 29 0.00194780656584547 64 6857784
SGTC_2516 gossypol 71.55 µM 2.81018250752528 0.00100198440504499 no 30 0.00247567068825676 72 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_647 0140-0236 81 µM 2.74951903036185 0.0012515514894071 no 31 0.00298413985611879 60 990837
SGTC_2511 berberine 10.47 µM 2.74643447709942 0.00126564497803782 no 32 0.00301234595031204 75 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_497 capsazepine 133 µM 2.73251060787922 0.00133108817219275 no 33 0.00314268237140383 62 2733484 A calcium channel blocker.
SGTC_2038 4100038 30.985 µM 2.72326203378425 0.00137625117460048 no 34 0.00323203826504116 114 3596803
SGTC_2395 5646831 180.19 µM 2.71099737684352 0.00143830148925314 no 35 0.0033540578468832 99 6808628
SGTC_2855 9016525 58.44 µM 2.70329847481962 0.00147854626686093 no 36 0.00343275328229164 94 43811474
SGTC_953 1188-0045 9.7 µM 2.68850683187159 0.00155876357228749 no 37 0.00358861834998375 104 6144426
SGTC_299 1273-0059 1.44 µM 2.68609759118448 0.0015721987915158 no 38 0.00361459851317678 85 2848077
SGTC_454 lyso-paf C-16 6.67 µM 2.65640446570439 0.00174667527950378 no 39 0.00394894125881568 98 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_2408 sulbentine 18.36 µM 2.65340619483637 0.00176523844504896 no 40 0.00398419577360482 135 67686 An antifungal agent of unknown mechanism. YDL205C HEM3
SGTC_457 grayanotoxin iii 135 µM 2.64423072261224 0.00182316709670263 no 41 0.00409384123666274 180 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity.
SGTC_1699 st031318 29.054 µM 2.63857890343317 0.00185970440218632 no 42 0.00416271618240693 90 5340658
SGTC_3209 9113616 49.47 µM 2.63708193100554 0.00186949274132803 no 43 0.00418113158356472 119 16649353
SGTC_2521 angolensin 13.4 µM 2.63666132664659 0.00187225138594421 no 44 0.00418631885666077 73 821428 A flavenoid.
SGTC_508 roscovitine 141 µM 2.63631512963579 0.00187452478587828 no 45 0.00419059278938608 53 160355 A CDKinase inhibitor.
SGTC_929 2805-0021 398 µM 2.62418137258873 0.00195580700922742 no 46 0.0043428759255557 90 3098024
SGTC_1476 4112-3294 3.34 µM 2.6199500762221 0.00198489613953293 no 47 0.00439713201385646 87 704369
SGTC_314 1671-0008 2.74 µM 2.57544231853624 0.00231555490987031 no 48 0.00500559849354473 168 3913060
SGTC_493 zm226600 134 µM 2.57339503522563 0.00233190071650093 no 49 0.00503530944360015 103 5240098 A potassium channel opener. YCR052W RSC6
SGTC_910 3454-3003 490 µM 2.57057969179292 0.00235454944637249 no 50 0.00507642322405981 110 820824
SGTC_2301 7769476 200 µM 2.56801318837951 0.00237536963162347 no 51 0.00511416322698939 88 977820
SGTC_669 0108-0021 26.2 µM 2.54134104806627 0.00260181535133201 no 52 0.00552140723873011 216 17201
SGTC_2987 9018338 71.43 µM 2.51497104405476 0.00284469212501318 no 53 0.00595210802021924 133 5055682
SGTC_703 3875-0075 71.8 µM 2.50887448131252 0.00290367612751255 no 54 0.00605582565053214 71 2850814
SGTC_2359 9039622 200 µM 2.50241117103967 0.00296741048778879 no 55 0.00616752876180906 117 6463596
SGTC_2227 7312221 64.1025 µM 2.47986471489803 0.00319972838144972 no 56 0.00657161195315428 46 887188 YOR168W | YOR169C GLN4 | YOR169C
SGTC_996 3970-0799 1.8 µM 2.47763687875558 0.00322355000226333 no 57 0.0066127834349766 242 6615648 YGL040C HEM2
SGTC_1028 k015-0029 4.8 µM 2.41448646790053 0.0039687161002741 no 58 0.00787870413992046 163 4588309
SGTC_2909 7941780 10.49 µM 2.38631090000962 0.00434836734649334 no 59 0.00850917853320595 126 1243215
SGTC_2976 9009005 19.48 µM 2.37793582905625 0.00446731130569783 no 60 0.00870492770327112 122 2993148
SGTC_1003 4049-0218 100 µM 2.37110015086639 0.00456653739666353 no 61 0.00886761234643165 166 295161
SGTC_317 4495-0002 170 µM 2.36273766596181 0.00469059910625805 no 62 0.00907025279446905 113 15991618
SGTC_488 nitrendipine 139 µM 2.35027425652274 0.00488108248951204 no 63 0.00937979150191795 154 4507 Dihydropyridine L-type calcium channel blocker.
SGTC_1151 3909-8316 15.3 µM 2.33365438214478 0.0051458058637969 no 64 0.00980691327488534 133 800431
SGTC_3207 9114163 49.47 µM 2.31479277330681 0.00546165248779764 no 65 0.0103121378099774 186 849233
SGTC_463 ikarugamyin 104 µM 2.31021418341266 0.00554087519702248 no 66 0.0104381495959453 46 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis.
SGTC_2930 9013230 14.89 µM 2.30702378591834 0.00559668007643894 no 67 0.0105267470648271 192 2995857
SGTC_597 k018-0003 82.8 µM 2.276380406163 0.00615862717130232 no 68 0.0114116256870996 128 6786234
SGTC_402 epigallocatechin gallate 10 µM 2.27338678751704 0.00621611840850184 no 69 0.0115014408237177 185 65064 An antioxidant.
SGTC_3042 9091578 49.47 µM 2.26922725510575 0.00629678944776217 no 70 0.0116272548227563 87 25236497
SGTC_113 0099-0221 2.5 µM 2.26547405458953 0.00637037403008806 no 71 0.0117418022131389 160 89219
SGTC_693 4161-2696 114 µM 2.25223733926029 0.00663600199629923 no 72 0.0121536387839655 98 805759
SGTC_310 1273-0058 1.06 µM 2.24180388041131 0.00685222845106872 no 73 0.0124870251713152 486 2734232
SGTC_2180 6301957 200 µM 2.23123124430425 0.00707766376735218 no 74 0.0128329076794978 103 845462
SGTC_2216 7189485 200 µM 2.23075795836228 0.00708790671845864 no 75 0.0128485830822897 97 731273
SGTC_1225 1216-0074 20.6 µM 2.22515510879576 0.00721016235209813 no 76 0.013035413638977 163 4241466
SGTC_329 k048-0121 21.3 µM 2.19310236032129 0.00794595473280689 no 77 0.0141500025060401 161 6832902
SGTC_3337 9144342 33.5465 µM 2.18729142862098 0.00808619940777447 no 78 0.0143606280300848 171 17682949
SGTC_2464 5717415 7.67 µM 2.18554767190492 0.00812870653702212 no 79 0.0144243572913699 172 5285744
SGTC_2438 5259590 200 µM 2.15110365280067 0.00900953009014544 no 80 0.0157340096317843 164 1201127
SGTC_698 k064-0052 127 µM 2.14910317039555 0.00906316405636455 no 81 0.0158131112524707 100 5088751
SGTC_63 0099-0242 26.702 µM 2.14402397259597 0.00920059798083807 no 82 0.0160154830072595 279 3898502 YLR359W ADE13
SGTC_850 0388-0143 75.9 µM 2.13696413122708 0.00939465293155065 no 83 0.0163004545636354 171 67273
SGTC_2465 5809242 33.21 µM 2.13063854835435 0.00957155652148027 no 84 0.0165594656265753 92 2731748
SGTC_76 0433-0009 400.328 µM 2.11279307665493 0.0100864152750237 no 85 0.01730924125839 138 2841569
SGTC_2458 5808907 16.39 µM 2.096348167308 0.0105820964890016 no 86 0.0180256584029231 142 2731747
SGTC_2040 5100729 123 µM 2.09012639137081 0.0107750926231223 no 87 0.0183032237617548 208 11840 YJR013W | YDR381W GPI14 | YRA1
SGTC_3296 9122258 64.045 µM 2.08521711904896 0.0109295314753552 no 88 0.0185247983262339 206 4730474
SGTC_2786 7743617 45.45 µM 2.08349482366028 0.0109841670500006 no 89 0.0186030715191757 175 583674
SGTC_2334 9017922 200 µM 2.07250075900276 0.0113385578113765 no 90 0.0191093827679727 169 3163164
SGTC_3347 9188721 44.724 µM 2.07158456338718 0.0113685347364952 no 91 0.0191521003709533 168 44118411 YKL104C | YBL026W GFA1 | LSM2
SGTC_3080 9117754 49.47 µM 2.07068117801553 0.0113981599273612 no 92 0.0191943001559073 214 9550191
SGTC_427 1354-0053 47.3 µM 2.05811107078794 0.0118173903838409 no 93 0.0197897362649073 210 6813657
SGTC_469 w7 172 µM 2.04742898853891 0.0121841044476639 no 94 0.0203079912706087 117 45115570 A P450 inhibitor.
SGTC_954 1189-0853 2.85 µM 2.02931952765358 0.0128283509723632 no 95 0.0212128777971433 236 2828194
SGTC_812 4251-0442 148 µM 2.029189525682 0.0128330803387976 no 96 0.021219495009045 164 5723007
SGTC_1439 4092-1168 46 µM 2.02454433435324 0.0130030612107218 no 97 0.0214570875814184 180 2886240
SGTC_2934 9036370 36.88 µM 2.02333633896996 0.0130475828551672 no 98 0.0215192413820458 244 6462800
SGTC_2046 4110841 106 µM 2.01913865466065 0.013203317934599 no 99 0.0217364050979135 201 44119630 YMR134W ERG29
SGTC_3015 9080845 49.47 µM 2.01790749540415 0.013249297760319 no 100 0.0218004481437337 172 5296973
SGTC_1746 st038117 42 µM 2.01488627174291 0.0133627173517374 no 101 0.0219582833753338 240 2898218
SGTC_2537 larixol 68.93 µM 2.0042221265494 0.0137697880741053 no 102 0.0225231356866568 250 6708759
SGTC_2316 5844804 197.44 µM 1.99901024585118 0.0139725970480802 no 103 0.0228036226477306 305 776813
SGTC_640 3381-0960 37.1 µM 1.99853244788166 0.0139913177194645 no 104 0.0228294828716443 210 1745025
SGTC_2821 7996764 71.43 µM 1.99654385759257 0.014069465402657 no 105 0.0229373784500627 279 2987135
SGTC_1582 3',3',6'-trihydroxyflavone 74 µM 1.99406170081444 0.0141675368506869 no 106 0.023072656024107 160 688803
SGTC_3253 9135987 49.47 µM 1.9704245137407 0.0151313370974984 no 107 0.0243948692042504 160 4182430
SGTC_2858 9025781 8.96 µM 1.96077404209591 0.0155407350831229 no 108 0.0249526936984354 365 4894980 YPL153C RAD53
SGTC_1975 st070967 30.8 µM 1.9570499344199 0.0157012445398324 no 109 0.0251707989103004 260 261391
SGTC_2653 dihydrofissinolide 100 µM 1.95684840213353 0.0157099710196438 no 110 0.0251826472298417 165 6857746
SGTC_213 1246-0773 967 nM 1.94647911213955 0.0161646172947658 no 111 0.0257986073197522 248 6251622
SGTC_2078 5212016 200 µM 1.93404666308925 0.0167245421582821 no 112 0.0265536954168479 184 1899708
SGTC_2100 5377183 190 µM 1.93311851227048 0.0167670013083327 no 113 0.0266108000350861 242 2844202
SGTC_1779 st039427 55 µM 1.92590406086409 0.0171001879896014 no 114 0.0270581771528301 304 1124498
SGTC_1 0258-0098 57.368 µM 1.92335193980493 0.0172194004124483 no 115 0.027217932858867 187 6790032 YDR047W HEM12
SGTC_873 0591-4978 488 µM 1.92252130593847 0.0172583530916761 no 116 0.0272700976631703 237 3305145
SGTC_2222 6885208 172.143 µM 1.9204387667982 0.0173563451232378 no 117 0.0274012503715229 142 609514
SGTC_1496 4469-0713 57.4 µM 1.91961564099486 0.0173952074003305 no 118 0.0274532334555895 227 746691
SGTC_851 0394-0702 453 µM 1.91953374820684 0.0173990778695538 no 119 0.0274584097471873 231 762646
SGTC_37 0566-0070 1.56 µM 1.9161767484774 0.0175583727389371 no 120 0.0276713009529049 272 1626686
SGTC_678 1218-2179 85.9 µM 1.91374516285498 0.0176745312432297 no 121 0.0278263626736542 150 6820081 YOR116C RPO31
SGTC_2367 9070478 135.38 µM 1.91238933211991 0.0177395845106366 no 122 0.0279131376386089 263 572802
SGTC_915 methyl methanesulfonate (MMS) 110 mM 1.90895890430291 0.0179050906912698 no 123 0.0281336966388443 271 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks.
SGTC_3108 9121785 49.47 µM 1.89856787016169 0.0184144801935666 no 124 0.0288106581149346 238 17140271
SGTC_1494 4358-1428 177 µM 1.89424590588896 0.0186299580630129 no 125 0.0290961887183618 258 1564571
SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM 1.88598534976837 0.0190477752908464 no 126 0.0296484644464148 255 521171
SGTC_2134 5324836 1.464 µM 1.8831522955579 0.019192893699882 no 127 0.0298398659110943 195 699272
SGTC_1395 3486-0190 4.35 µM 1.88252434519418 0.0192251863292442 no 128 0.0298824287932662 247 6748079
SGTC_2586 curcumin 80 µM 1.87767878744856 0.0194759278466469 no 129 0.0302125601520653 342 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40
SGTC_1929 genistein trimethyl ether 50.5 µM 1.8730269563536 0.0197192527772573 no 130 0.0305323313533409 259 136420
SGTC_1174 0739-0097 51.1 µM 1.87143570767033 0.0198030769987937 no 131 0.0306423567230822 273 728447
SGTC_460 trequinsin 123 µM 1.87075252242513 0.0198391587021586 no 132 0.0306896955567954 200 5537 A vasodilator.
SGTC_131 0141-0277 33.849 µM 1.86943785161452 0.019908748643925 no 133 0.03078096127405 289 1547771
SGTC_2394 5221648 200 µM 1.86863521045571 0.0199513368832163 no 134 0.0308367917840923 309 788586
SGTC_1548 st061468 90.8 µM 1.85769760168635 0.0205394336323088 no 135 0.0316059846450472 220 390799
SGTC_1903 st060211 78.3 µM 1.85167211420245 0.0208696423357384 no 136 0.0320364603388388 295 688960
SGTC_707 0865-0008 204 µM 1.8486069650316 0.0210393359877637 no 137 0.0322572931210623 236 723043
SGTC_1756 st041558 35.5 µM 1.84823968219642 0.0210597477205828 no 138 0.0322838385962753 260 3955792
SGTC_877 0771-0151 33.1 µM 1.83815099458044 0.0216270127374338 no 139 0.0330200793255607 272 6166523
SGTC_43 0570-0105 72.5 µM 1.82881297722088 0.0221635226147229 no 140 0.0337138151180248 437 1114046 YDL195W SEC31
SGTC_2228 7354201 200 µM 1.82752318831172 0.0222385021241719 no 141 0.0338105714916865 211 753451
SGTC_989 1501-0895 10.3 µM 1.82629378450893 0.0223101703732252 no 142 0.0339030104875546 218 2830112
SGTC_1878 temozolomide 1 mM 1.82134941031232 0.0226003739328834 no 143 0.0342768800264683 228 5394 DNA alkylating agent.
SGTC_2621 lithochol-11-enic acid 100 µM 1.82091762452811 0.0226258674411114 no 144 0.0343096898325309 318 6708711
SGTC_3107 9121808 49.47 µM 1.81854571127413 0.0227663427359206 no 145 0.0344903833867272 177 662681
SGTC_848 0368-0089 85.6 µM 1.8173865871875 0.0228352581489456 no 146 0.0345789700250371 281 762535
SGTC_1325 1431-0015 227 µM 1.81657007218558 0.0228839092784685 no 147 0.0346414847226654 251 1103340
SGTC_1243 0416-0003 5.65 µM 1.80647860902783 0.0234924411106951 no 148 0.0354218062453935 314 2141977
SGTC_2597 laccaic acid a 100 µM 1.79864321404221 0.0239742661439921 no 149 0.0360375684558438 332 5491415 A textile dye.
SGTC_1067 clotrimazole 1.36 µM 1.79504622330621 0.0241982231116593 no 150 0.0363231678373744 303 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_642 0335-0876 158 µM 1.79353189588386 0.0242930328772358 no 151 0.0364439576244559 318 6812350
SGTC_2818 7996756 12.99 µM 1.78624411426521 0.0247536836245136 no 152 0.0370298706055739 199 2241621
SGTC_2693 st077581 40.7 µM 1.7840154652676 0.0248960080920134 no 153 0.0372105760969099 380 25238761
SGTC_2756 carbadox 75.1 µM 1.77878125227209 0.025232972051901 no 154 0.0376378159910036 358 2553 A substituted quinoxaline antibiotic. YLR208W SEC13
SGTC_1234 0326-0494 15.5 µM 1.77866659076525 0.0252403962046991 no 155 0.0376472198152635 258 1547813
SGTC_1973 st070275 50.2 µM 1.76340012193542 0.0262453519626201 no 156 0.0389165146316943 258 17118334
SGTC_1486 3970-0793 4.53 µM 1.76235265257718 0.0263155138051886 no 157 0.0390048665034189 252 2844330
SGTC_2781 5567276 71.43 µM 1.76012100934003 0.0264655172078112 no 158 0.0391936456483321 324 2853274
SGTC_948 3448-0295 75.3 µM 1.74664725564456 0.0273864309714756 no 159 0.0403492723802774 347 678569
SGTC_1452 4194-0072 190 µM 1.74381926696383 0.0275830755893043 no 160 0.0405953048713611 324 1343545
SGTC_1898 st060199 18.6 µM 1.74306198970377 0.0276359323137545 no 161 0.040661393609173 268 688866
SGTC_2925 9010536 32.5 µM 1.74006633589497 0.0278458522879267 no 162 0.0409236852839979 399 2994177
SGTC_1753 st043925 64 µM 1.73900432562413 0.0279205907240308 no 163 0.0410170010291085 322 670181
SGTC_2429 5902844 64.44 µM 1.73890074353233 0.0279278891963168 no 164 0.0410261117146935 345 1927790 YGL093W | YPR107C SPC105 | YTH1
SGTC_2338 7999974 200 µM 1.73755255308517 0.0280230287440807 no 165 0.0411448431673083 320 315925
SGTC_2596 sinensetin 100 µM 1.73092473635456 0.0284946759748842 no 166 0.0417325945443301 304 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets.
SGTC_2132 5317594 122.667 µM 1.72569704301959 0.0288713302220631 no 167 0.0422009651516794 263 794577
SGTC_1921 5740136 50 µM 1.72516629282409 0.0289098010266563 no 168 0.042248754163679 374 1774243
SGTC_3300 9124615 50.48 µM 1.7214934464407 0.0291771921948304 no 169 0.0425806601901228 332 24824903
SGTC_1808 st050063 61.5 µM 1.72042173306849 0.0292556013411632 no 170 0.0426779046464982 298 4011993
SGTC_2587 piperic acid 92.2 µM 1.72025369976653 0.0292679109212328 no 171 0.0426931678163242 301 5370536
SGTC_1957 st077035 62.4 µM 1.71255758845316 0.0298363307834022 no 172 0.0433969807192441 287 705593
SGTC_3084 9116877 49.47 µM 1.70844489112374 0.0301438220497871 no 173 0.0437769118324063 245 27241325
SGTC_257 daunorubicin 18.5 µM 1.70834196807185 0.0301515507973 no 174 0.0437864541754039 258 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_714 4296-0578 26.1 µM 1.69560644344577 0.031120649189985 no 175 0.0449802183531903 188 1589775
SGTC_963 1269-2853 151 µM 1.69065431294443 0.0315043706183466 no 176 0.0454514224386829 323 3668223
SGTC_719 2810-4230 27.3 µM 1.69047813874956 0.0315180933988752 no 177 0.0454682585764935 252 721079
SGTC_334 1502-1024 68.5 µM 1.68246876006001 0.0321472078093154 no 178 0.0462389888854866 339 3296216
SGTC_1745 st081495 74 µM 1.68180606114735 0.0321997220697116 no 179 0.0463032265121759 416 13842402 YBL026W LSM2
SGTC_3124 9127567 49.47 µM 1.67725204659666 0.0325625141793791 no 180 0.0467466026860046 306 17592030
SGTC_2442 5158906 48.48 µM 1.67422455297468 0.0328055578204973 no 181 0.0470432378861071 349 1893835
SGTC_701 4424-0219 185 µM 1.67244632223941 0.0329490079456396 no 182 0.047218172127634 347 2911779
SGTC_2339 9000433 200 µM 1.66867402542665 0.0332550315511178 no 183 0.0475909997634522 313 2988954
SGTC_1412 3909-8563 178 µM 1.66633103890408 0.0334462796959544 no 184 0.0478237489015351 364 23767530
SGTC_391 gliotoxin 8.33 µM 1.66340944762675 0.033686024551023 no 185 0.0481152516219746 372 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion
SGTC_2545 solidagenone 89.61 µM 1.6613741859983 0.0338538717901784 no 186 0.0483191594664141 169 6708572 An anti ulcer agent
SGTC_1546 5-methoxyflavanone 78.7 µM 1.65764215021577 0.0341634386169104 no 187 0.0486948583400862 331 147795
SGTC_1777 st045864 34.765 µM 1.65736979362642 0.0341861210105114 no 188 0.0487223672691914 334 4691462
SGTC_78 0336-0123 156.75 µM 1.65148384761564 0.0346793465743744 no 189 0.0493199081362594 312 6765896
SGTC_3309 9129340 25.759 µM 1.65134642703818 0.0346909314780799 no 190 0.0493339286513699 347 17158987
SGTC_539 4859-0462 2.54 µM 1.64942040238007 0.0348536349320607 no 191 0.0495307688884616 321 46499474 YNL221C | YBR257W POP1 | POP4
SGTC_2805 7950783 58.44 µM 1.6478234642 0.0349890129574757 no 192 0.0496944512855909 410 1178958 YDL195W SEC31
SGTC_1431 4049-0260 9.09 µM 1.64654684081723 0.0350975469222254 no 193 0.0498256123423422 342 3854841
SGTC_1976 st070609 63.5 µM 1.64583319332046 0.0351583389660286 no 194 0.0498990531581949 356 682556
SGTC_2014 4013930 200 µM 1.64359890781597 0.0353492253750395 no 195 0.0501295398556556 424 64556
SGTC_1810 st050138 53 µM 1.64344035692045 0.0353628034232307 no 196 0.0501459280091634 285 3444541
SGTC_2566 crystal violet carbinol 226 nM 1.64150199167585 0.0355291480150279 no 197 0.0503466269930165 322 68050 Cationic dye that binds acidic phospholipids including cardiolipin.
SGTC_1470 k295-0292 231 µM 1.64047286470466 0.0356177249332569 no 198 0.050453442999932 349 5045612
SGTC_1093 fluphenazine 7.97 µM 1.6377369208315 0.0358540880898047 no 199 0.0507382926029974 392 6602611 An atypical antipsychotic.
SGTC_4 0960-0234 25.671 µM 1.63045277982811 0.036489649102297 no 200 0.0515029187120805 331 6821112
SGTC_3242 9133940 49.47 µM 1.62350111927464 0.0371047685943345 no 201 0.0522411621446388 329 17248444
SGTC_1679 SEC14.276 6.7 µM 1.62308683513422 0.0371416925977748 no 202 0.0522854217260987 427 1005053 YMR079W SEC14
SGTC_1793 st048256 72.231 µM 1.62212099752612 0.0372278916531997 no 203 0.0523887215331363 302 672022
SGTC_2436 5633522 8.09 µM 1.62031792316616 0.0373892497820259 no 204 0.0525820003672807 376 5724242
SGTC_1224 0823-0416 294 µM 1.61926199817951 0.0374840100274509 no 205 0.0526954517285784 345 3598164
SGTC_2214 7179297 48.276 µM 1.61917982495919 0.0374913925898503 no 206 0.0527042887753853 292 769744
SGTC_2549 cedrol 20.94 µM 1.60990421516898 0.0383323897534825 no 207 0.0537093843251314 306 6708665 A sedative which affects the nervous system.
SGTC_431 k089-0097 107 µM 1.60913242776099 0.0384030535211415 no 208 0.0537936939494998 455 5499420
SGTC_71 0417-1750 47.813 µM 1.60825407583475 0.0384836033414965 no 209 0.053889772094343 414 6811472
SGTC_1713 st033146 12.748 µM 1.60723510846226 0.0385772208693508 no 210 0.0540014015787364 373 674619
SGTC_820 1582-0060 59.9 µM 1.60091998953206 0.0391615687871423 no 211 0.054697320775313 408 3848840
SGTC_1623 st003709 20.3 µM 1.5949840035546 0.0397173842809868 no 212 0.0553579064837045 458 16192618
SGTC_2962 9082311 13.18 µM 1.58773202078596 0.0404051096342168 no 213 0.0561734745294616 351 16459453
SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM 1.58611101120513 0.0405601491796941 no 214 0.0563570647324681 376 688798
SGTC_1212 0520-0165 585 µM 1.58548289670092 0.0406203541139395 no 215 0.0564283299220468 395 5403258
SGTC_499 genistein 192 µM 1.58546269149337 0.0406222919916965 no 216 0.0564306235615235 279 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger.
SGTC_3325 9138760 55.175 µM 1.58464780296194 0.0407005103618327 no 217 0.0565231887163347 378 43844959
SGTC_62 0180-0423 3.232 µM 1.57748172508992 0.0413936335349988 no 218 0.0573423619225386 367 30102 YGL099W LSG1
SGTC_2876 9059903 25.97 µM 1.57558158244866 0.0415790165206363 no 219 0.0575611316927543 386 6916095
SGTC_1706 st031321 9.9705 µM 1.5576517478722 0.0433616138167277 no 220 0.0596579122913915 372 6103185
SGTC_143 4032-1194 15.74 µM 1.55392552874764 0.0437397132595325 no 221 0.060101090738493 487 1806963
SGTC_2404 5161160 200 µM 1.55245963265313 0.0438891848837979 no 222 0.0602761422006134 430 2831543
SGTC_713 1488-1073 324 µM 1.55137620779764 0.0439999219883502 no 223 0.0604057767567458 347 3312542
SGTC_2841 9004761 38.96 µM 1.55119137315515 0.0440188364589051 no 224 0.0604279144641171 366 2991039
SGTC_1906 st060206 94.7 µM 1.55106553042781 0.0440317179289874 no 225 0.0604429903222059 415 5133468
SGTC_2568 diosmetin 100 µM 1.54366859361524 0.0447942365874398 no 226 0.0613343192109317 422 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.
SGTC_260 nsc-65238 3.989 µM 1.5396705466974 0.0452107838182919 no 227 0.0618203398558594 361 3246252
SGTC_1512 0259-0544 12.2 µM 1.5384904595145 0.0453343283124843 no 228 0.0619643697314231 439 18476
SGTC_586 0957-0265 8.15 µM 1.53746674652372 0.0454417216745298 no 229 0.0620895261018117 319 6752309 YPR165W | YPR107C RHO1 | YTH1
SGTC_362 0310-0100 9.03 µM 1.53658258255477 0.0455346401227284 no 230 0.0621977802441066 431 790235
SGTC_330 1488-0319 80.1 µM 1.53410617737193 0.0457957035588198 no 231 0.062501766927435 385 6846614
SGTC_2333 9017922 200 µM 1.52510651798876 0.0467545949818596 no 232 0.0636162658741513 402 3163164
SGTC_2604 4'-hydroxychalcone 11.32 µM 1.52444398095363 0.0468258184857816 no 233 0.0636989202831863 388 5282362
SGTC_3264 9137442 49.47 µM 1.52037662147429 0.0472649735097258 no 234 0.0642081733634989 363 17015726
SGTC_1327 1436-0082 2.18 µM 1.51763243148463 0.0475631256296882 no 235 0.0645535431631247 392 15992205
SGTC_189 3970-0742 2.116 µM 1.51735559153182 0.0475932873478093 no 236 0.0645884648132739 368 2891807
SGTC_1314 1222-0010 41.1 µM 1.51654308505789 0.0476818984161211 no 237 0.0646910422236982 378 3526027
SGTC_3034 9090421 49.47 µM 1.51449228115799 0.0479061445301556 no 238 0.0649505150318826 360 17173761
SGTC_412 gemfibrozil 100 µM 1.51136719898693 0.0482494807046808 no 239 0.0653474607926756 340 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels.
SGTC_371 0195-0006 7.36 µM 1.50340419864705 0.0491332358416064 no 240 0.0663674222722831 348 3928593
SGTC_1315 1237-0019 3.69 µM 1.50229127475884 0.0492577743846127 no 241 0.0665109505160443 423 825140
SGTC_2811 7967822 32.47 µM 1.49812783078482 0.0497259094011185 no 242 0.067050020772361 443 2232244
SGTC_2635 hydroquinidine 100 µM 1.49603529224376 0.0499625298135466 no 243 0.0673222292713908 419 442912 An experimental heart treatment.
SGTC_2279 7948423 32.93 µM 1.47930963779668 0.0518862559752226 no 244 0.0695287890929704 389 1247112
SGTC_1066 ketoconazole 628 nM 1.47827022484078 0.0520077218266879 no 245 0.0696677319929227 478 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W
SGTC_2750 bromebric acid 70.15 µM 1.47543772496074 0.0523398747735129 no 246 0.0700474496544529 501 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2
SGTC_2856 9022925 19.48 µM 1.4753490338922 0.0523503022595809 no 247 0.0700593650087619 448 4944862
SGTC_1651 st011928 86.1 µM 1.46562768885484 0.0535032831487121 no 248 0.0713748718479875 433 720198
SGTC_3021 9087658 49.47 µM 1.46237710942343 0.0538932693966269 no 249 0.0718189493067214 368 25237042
SGTC_2076 5212012 200 µM 1.45741584295528 0.0544928294217922 no 250 0.0725008132149591 338 604802
SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM 1.45673033035147 0.0545760855918034 no 251 0.0725954169903255 717 16725076
SGTC_2170 morpholine 200 µM 1.45440643089613 0.0548590741276787 no 252 0.0729168290312538 405 121171 Reacts with secondary amines.
SGTC_3147 9097027 49.47 µM 1.45270571086736 0.0550669101454984 no 253 0.0731527403489709 456 25236841
SGTC_2736 butenafine 14.65 µM 1.44808157370305 0.0556351475261616 no 254 0.0737971190927929 499 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_1401 3807-4679 7.6 µM 1.43985070554257 0.0566580383948105 no 255 0.074954820993312 408 3291456
SGTC_1633 st005664 67.9 µM 1.43738869320491 0.0569668666677429 no 256 0.0753037898684347 474 2063822
SGTC_897 1000-0139 31.4 µM 1.43266920560982 0.0575625708092939 no 257 0.0759761969406886 447 6151020
SGTC_2898 9056270 58.44 µM 1.43024098302568 0.0578709696131291 no 258 0.0763239333342074 379 19154699
SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM 1.42920885966891 0.0580024481944231 no 259 0.0764721060079893 504 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis.
SGTC_829 1635-0120 117 µM 1.41686421142746 0.0595932466303962 no 260 0.0782613158849599 504 285054
SGTC_1269 0831-0796 3.05 µM 1.41611729291903 0.0596905848908507 no 261 0.078370582898487 463 927758
SGTC_762 1165-0429 115 µM 1.41554703669736 0.0597649843881389 no 262 0.078454083755255 467 5967793
SGTC_224 benfluorex 43.875 µM 1.4147031551572 0.0598752161817142 no 263 0.0785777744568353 338 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis.
SGTC_2079 5212404 121 µM 1.41343694146439 0.0600409136655444 no 264 0.0787636450814225 443 758462
SGTC_553 k007-0256 45.7 µM 1.41314501500107 0.0600791662251271 no 265 0.0788065449047788 492 6287000
SGTC_741 4582-0002 126 µM 1.41302487905292 0.0600949137702662 no 266 0.0788242045293535 486 2912688
SGTC_1328 1441-0025 69.2 µM 1.41044882258371 0.0604333641715073 no 267 0.0792035989234355 423 4562601
SGTC_884 0851-0618 334 µM 1.40467478538741 0.0611973928391676 no 268 0.080059003474421 505 9642473
SGTC_2160 5660466 132.927 µM 1.40303530362751 0.0614157015847882 no 269 0.0803031558580289 462 2859134
SGTC_426 0988-0037 14.6 µM 1.40153951439685 0.0616154068895351 no 270 0.0805263999661839 548 5383008
SGTC_502 l-744,832 89.3 µM 1.40099250858686 0.0616885650393287 no 271 0.0806081566597776 483 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.
SGTC_259 usnic acid 108.925 µM 1.39842856853685 0.0620323781469484 no 272 0.0809922045926478 489 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_2606 farnesol 9.78 µM 1.39326861459905 0.0627288360005072 no 273 0.0817692888666863 496 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_1282 0886-0010 32.4 µM 1.38527591352893 0.0638196514907129 no 274 0.0829840579326986 549 2836211 YNL267W PIK1
SGTC_3066 9117245 49.47 µM 1.38260167928583 0.0641878973667533 no 275 0.0833935169414371 499 17176980
SGTC_162 k030-0015 37.8 µM 1.37996745224968 0.0645522468579914 no 276 0.083798333197944 483 1809920 YMR134W ERG29
SGTC_2409 alverine citrate 63.97 µM 1.37938726608883 0.064632709985047 no 277 0.0838876916373778 510 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_1105 epirubicin 18.1 µM 1.3788671394883 0.0647049099520899 no 278 0.0839678607090682 481 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_186 3455-3465 67.277 µM 1.3759393476145 0.0651124926536621 no 279 0.0844202059658939 365 755278
SGTC_1056 3448-1962 115 µM 1.37499591435704 0.0652442531323896 no 280 0.084566355677885 462 715507
SGTC_1277 0873-0036 22 µM 1.37357054797361 0.0654437129392839 no 281 0.0847875227753905 539 5965735
SGTC_171 k064-0041 9.68 µM 1.36888829642552 0.0661022571552729 no 282 0.085517097342874 400 53325
SGTC_2595 hexamethylquercetagetin 100 µM 1.36842621368567 0.0661675249899259 no 283 0.0855893518060603 480 386331
SGTC_1986 st071812 45 µM 1.36800378466594 0.0662272355186319 no 284 0.0856554457262293 443 11838594
SGTC_1686 st019653 115.5 µM 1.36748291036215 0.0663009187775136 no 285 0.0857369951528 469 97252
SGTC_3038 9091290 49.47 µM 1.36665929811436 0.066417557102243 no 286 0.085866060602204 506 25236843
SGTC_840 0245-0196 390 µM 1.36633957425251 0.066462878542132 no 287 0.0859162025935409 555 3827528
SGTC_2356 9061756 188.97 µM 1.35918399343456 0.0674834715270988 no 288 0.0870441460695144 464 20104043
SGTC_1591 genipin 88.4 µM 1.35860309107633 0.0675668536452811 no 289 0.0871361975815425 458 442424 A DNA cross-linking agent.
SGTC_987 1497-1013 404 µM 1.35129341466647 0.0686228922398186 no 290 0.0883007303503414 465 1676435
SGTC_852 0418-0143 439 µM 1.3472666776195 0.0692100534782973 no 291 0.0889471800304981 591 5369229
SGTC_837 0091-0265 12.5 µM 1.34301366620171 0.0698344042586167 no 292 0.0896337743555283 551 759367
SGTC_1708 st033234 31.827 µM 1.33695440031179 0.0707313924730122 no 293 0.0906187609294808 559 674664
SGTC_286 k060-0067 22.9 µM 1.33664619199171 0.0707772538552785 no 294 0.090669076766169 492 5985051
SGTC_876 0720-0963 56.8 µM 1.3327589553775 0.0713576374885984 no 295 0.0913054595737042 562 765861
SGTC_2098 5376439 882.5 nM 1.3313852495672 0.0715636098393178 no 296 0.0915311401956553 555 2844116
SGTC_2058 5236698 133 µM 1.32790513804893 0.0720874565665258 no 297 0.0921047235684194 530 766665
SGTC_2159 5658611 73.75 µM 1.32420961120655 0.0726469416885582 no 298 0.0927167198604354 497 793844
SGTC_3048 9093155 49.47 µM 1.32043932586289 0.0732211658392462 no 299 0.0933441904970443 452 25236002
SGTC_413 propylparaben 100 µM 1.31616704800734 0.0738760344189958 no 300 0.0940589905099016 528 7175 A pharmaceutical preservative.
SGTC_1606 st000094 49.2 µM 1.31438781973052 0.0741500767589368 no 301 0.094357863647976 555 1242210
SGTC_737 1950-0117 57.9 µM 1.31423482535713 0.0741736776411755 no 302 0.094383596166048 521 5393513
SGTC_1515 3460-0031 42.1 µM 1.30976257439822 0.0748661041984743 no 303 0.0951380838124028 458 2876596
SGTC_1998 st075797 76.8 µM 1.30933981451143 0.0749318132327561 no 304 0.0952096343257769 585 24208315
SGTC_570 0987-0065 62.6 µM 1.30717224028558 0.0752694077478376 no 305 0.0955771105580443 425 3104428
SGTC_998 3996-0085 177 µM 1.30407728890735 0.0757534471701808 no 306 0.0961036157592118 603 715391
SGTC_188 3229-0966 278.469 µM 1.30280699074193 0.0759528021993164 no 307 0.0963203317581411 640 5722370
SGTC_2023 5144124 124 µM 1.30269884363288 0.0759697927677657 no 308 0.0963387984987037 540 2830192
SGTC_1984 st072354 53.1 µM 1.30246521264325 0.0760065074956014 no 309 0.0963787012150969 535 5762938
SGTC_2272 7805186 180 µM 1.30008310767608 0.0763816228277146 no 310 0.0967862433095162 529 2956062 YPR165W RHO1
SGTC_855 0428-0020 25 µM 1.29971355001041 0.0764399438893228 no 311 0.0968495822573969 508 6812414
SGTC_2681 menadione 3.18 µM 1.29524067187871 0.0771485118429655 no 312 0.097618609171368 543 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_1076 itraconazole 331 nM 1.29507235794616 0.077175272289161 no 313 0.0976476347409249 560 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1
SGTC_2449 5812982 45.77 µM 1.29311400299287 0.077487152266352 no 314 0.0979858163597579 506 776185
SGTC_1017 4239-0030 168 µM 1.28619374122109 0.078596915739488 no 315 0.0991877274106476 594 1149593
SGTC_2991 9074669 71.4286 µM 1.28480771236488 0.078820626338753 no 316 0.0994297433185292 626 17333109
SGTC_2691 st077356 60.2 µM 1.28431311544527 0.0789005729439395 no 317 0.0995162098026418 569 2839272
SGTC_187 1488-2104 32.728 µM 1.28262207591194 0.0791743765140667 no 318 0.0998122560658223 577 2852859
SGTC_1464 k208-0027 110 µM 1.28228312151157 0.0792293445490153 no 319 0.0998716733237717 580 X1464
SGTC_985 1493-0307 8.71 µM 1.28089633969631 0.0794545390961432 no 320 0.100115039328015 492 3278274
SGTC_2826 7992541 19.48 µM 1.28068788902359 0.0794884304942429 no 321 0.100151657685285 538 2985066
SGTC_2 0422-0095 29 µM 1.28050236723824 0.0795186031504308 no 322 0.100184256366793 444 6790840
SGTC_2217 6934799 96.0675 µM 1.28025332148357 0.0795591207624633 no 323 0.100228029244256 553 675606
SGTC_3219 9131112 49.47 µM 1.2794524413058 0.0796895230049668 no 324 0.100368888489334 541 17612988 YMR079W SEC14
SGTC_3316 9136639 10.545 µM 1.27369365674493 0.0806319549354413 no 325 0.101386002688293 546 4903665
SGTC_2448 5185112 27.17 µM 1.27357068519763 0.0806521707754573 no 326 0.101407803452392 512 5718189
SGTC_543 3844-1095 191 µM 1.27086647392314 0.08109769631542 no 327 0.101888077640645 597 4230703
SGTC_1940 st075990 51.1 µM 1.2676328032455 0.081632886965228 no 328 0.10246455589227 616 1084979
SGTC_1967 st070177 51.4 µM 1.26420779392429 0.0822026445594764 no 329 0.103077727063559 532 5729214
SGTC_3285 9112818 20.8695 µM 1.26116110993077 0.0827119795875368 no 330 0.103625403543214 618 17017947 YPR165W RHO1
SGTC_1726 st035556 14.5795 µM 1.25765521026553 0.0833010195296959 no 331 0.104258238563782 620 5919439
SGTC_2839 9003951 25.97 µM 1.25360920638508 0.083984717859161 no 332 0.104992041648458 540 2990634
SGTC_3250 9135583 49.47 µM 1.25271744337522 0.0841359740926027 no 333 0.105154277757853 545 7699353
SGTC_1059 3448-6867 171 µM 1.25167078444835 0.0843137637227641 no 334 0.105344925003448 576 3934407
SGTC_781 4335-2806 94.4 µM 1.24414772490232 0.0855999648640133 no 335 0.106722599508897 674 845254
SGTC_2139 5578692 56.4705 µM 1.23862320460936 0.086553795776558 no 336 0.107742535261428 523 650991 YMR113W FOL3
SGTC_2812 7970281 58.44 µM 1.23816174384563 0.0866338269738407 no 337 0.107828046733458 593 2233435
SGTC_223 busulfan 5 mM 1.2380529384075 0.0866527051699792 no 338 0.107848216159367 482 2478 A DNA alkylator.
SGTC_1191 1487-1166 10.6 µM 1.23580860131088 0.0870427930876314 no 339 0.10826485851356 689 3955771
SGTC_3091 9116372 49.47 µM 1.23454204423396 0.0872635113596392 no 340 0.108500494927469 543 17169793
SGTC_994 3910-0338 138 µM 1.23299919686177 0.0875329419480338 no 341 0.108788031907373 629 3479481
SGTC_476 mead acid 10 µM 1.23020020529077 0.0880233194964707 no 342 0.109311071519678 521 5312531 An omega 9 fatty acid.
SGTC_1448 4255-0083 152 µM 1.228857111974 0.0882593526870837 no 343 0.109562691974876 608 5399660
SGTC_571 k831-0106 44.2 µM 1.2274008759286 0.0885158020711103 no 344 0.109835978676583 563 4783639
SGTC_1520 flindersine 88 µM 1.22724780240775 0.088542791181668 no 345 0.109864733838181 617 68230 Flindersine is a natural alkaloid of the quinoline subtype.
SGTC_1817 st052116 64.4 µM 1.2229581372177 0.089301617327241 no 346 0.110672754130209 568 4361398
SGTC_1419 3993-2473 62.6 µM 1.21961590586193 0.0898961912174578 no 347 0.111305256922061 620 704026
SGTC_2622 2-methoxyxanthone 59.94 µM 1.21958862136982 0.0899010571323337 no 348 0.111310431020517 650 71034 A hepatoprotective.
SGTC_3194 9111903 49.47 µM 1.21797731478544 0.0901887646987903 no 349 0.111616296755047 590 17087251
SGTC_3155 9099265 49.47 µM 1.21780500313752 0.0902195723175636 no 350 0.111649041312828 557 25236499
SGTC_3197 9113331 49.47 µM 1.21627778815027 0.0904929649890975 no 351 0.111939559947207 607 16610459 YLR208W | YDL195W SEC13 | SEC31
SGTC_1007 4101-0031 70 µM 1.21552408660411 0.090628114486689 no 352 0.112083133920489 626 1146276
SGTC_2009 4012297 12.05 µM 1.21542848425508 0.0906452680606041 no 353 0.112101354788986 583 45595307
SGTC_1143 3454-2408 5.08 µM 1.21110325664874 0.0914238505192111 no 354 0.112927916716806 565 X1143
SGTC_2025 5147754 141 µM 1.21033520622573 0.0915626236965337 no 355 0.113075146767694 595 315777 YLR208W SEC13
SGTC_3213 9129884 49.47 µM 1.21010901172203 0.0916035227979695 no 356 0.113118532817492 526 17190742
SGTC_924 2046-0044 21.3 µM 1.20979736138967 0.0916598956703379 no 357 0.113178329485564 610 3623589
SGTC_2791 5663188 71.43 µM 1.2084608041839 0.0919019503469259 no 358 0.113435031842395 571 54690634
SGTC_860 0443-0016 25.1 µM 1.20531240196394 0.0924740062905956 no 359 0.114041361841241 613 5337942
SGTC_3257 9139206 32.98 µM 1.20385417953185 0.0927398522126627 no 360 0.114322972229926 549 4910041
SGTC_739 1486-1183 203 µM 1.197820589498 0.0938458338325666 no 361 0.115493434906818 641 4346692
SGTC_1647 st011722 22.4 µM 1.19724043823961 0.0939526888072146 no 362 0.115606426189003 583 2854783
SGTC_595 3909-8003 73.7 µM 1.19397972331815 0.0945549334693787 no 363 0.116242949904042 622 699517
SGTC_2618 avocadyne 43.43 µM 1.19200704306817 0.0949206608439077 no 364 0.116629241826442 605 3015189
SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM 1.18915001803628 0.0954521885216855 no 365 0.117190319389126 565 17037758
SGTC_3150 9097574 49.47 µM 1.18773867307029 0.0957155654676105 no 366 0.117468191208254 600 17217476
SGTC_3268 9137683 49.47 µM 1.18519830072648 0.0961909815314858 no 367 0.117969525828363 593 1953228
SGTC_408 cantharidin 100 µM 1.18145692185158 0.0968943164989963 no 368 0.118710628436344 652 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_1330 1469-0054 61.8 µM 1.18105863164552 0.0969694121431019 no 369 0.118789716139433 643 7102664
SGTC_471 1-acyl-paf 4 µM 1.18065802304978 0.0970449879990711 no 370 0.118869301738081 624 16759367
SGTC_484 loperamide 105 µM 1.17942945498251 0.0972770301630785 no 371 0.119113606012748 525 3955 An opioid-receptor agonist.
SGTC_132 0417-1715 25.805 µM 1.17817202356622 0.0975149450882379 no 372 0.119364016685657 671 6769098
SGTC_995 3931-2021 34.6 µM 1.17651414552545 0.0978292792335388 no 373 0.119694741587186 618 730143
SGTC_1089 terbinafine 2.25 µM 1.17523241435514 0.0980728044169128 no 374 0.119950872688447 625 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_52 0329-0193 875 nM 1.17265227726948 0.0985643693514082 no 375 0.120467638122944 632 3739292
SGTC_2231 micatex 6.853 µM 1.17223532322495 0.0986439759831607 no 376 0.12055129513482 610 20737 An antifungal of unknown mechanism.
SGTC_2093 5331342 194.4 µM 1.16976656480899 0.0991162862210249 no 377 0.121047461157206 657 33839
SGTC_170 4197-0004 226 µM 1.1695581289058 0.099156238698465 no 378 0.121089417853251 580 218692
SGTC_810 3825-7150 143 µM 1.16779176503277 0.0994952838312127 no 379 0.121445385323891 692 22330411 YGL099W LSG1
SGTC_1376 2910-0861 41.3 µM 1.16676763519929 0.0996922483145697 no 380 0.121652110264757 672 1112859
SGTC_1118 chelidonine 707.474 nM 1.16533961790065 0.0999673652943749 no 381 0.121940774219179 707 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor.
SGTC_2002 4023503 131 µM 1.16490536042142 0.100051137708747 no 382 0.122028651727203 766 4736863 YCR052W RSC6
SGTC_2065 5221596 34.26 µM 1.16487496818575 0.10005700257989 no 383 0.122034803646349 629 788581
SGTC_215 1287-0124 461.5 µM 1.15980596146864 0.10103869794413 no 384 0.123063908190141 597 5560863
SGTC_1889 st059080 5.18 µM 1.15711474084254 0.101562740861186 no 385 0.123612742455553 713 176925 Isolated from Daphnopsis sellowiana.
SGTC_2529 gangaleoidin 93.61 µM 1.15463488801727 0.102047375310427 no 386 0.124119986761007 653 4565183
SGTC_2580 diallyl disulphide 81.36 µM 1.15109740027736 0.102741610938948 no 387 0.124846083707794 622 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.
SGTC_335 4077-0256 27.6 µM 1.15088972887942 0.102782473069922 no 388 0.124888801921824 741 3121989
SGTC_3258 9138477 49.47 µM 1.14957422638262 0.103041590188439 no 389 0.125159639334435 658 4970355
SGTC_2251 lansoprazole 556 µM 1.14940606325041 0.103074747785507 no 390 0.125194290529131 518 3883 Gastric proton pump inhibitor. YBR192W RIM2
SGTC_1549 4'-methoxyflavonol 74.6 µM 1.14884841918083 0.103184756816279 no 391 0.125309244943549 675 97141
SGTC_254 nsc-64875 3.808 µM 1.14773799063937 0.103404070078353 no 392 0.125538371416363 651 56993
SGTC_2674 ligustilide 100 µM 1.14432545046268 0.1040801752762 no 393 0.126244346171613 625 5319022 A signalling regulator.
SGTC_1807 st050092 58.9 µM 1.14301165510473 0.104341321988434 no 394 0.126516875996375 645 5008496
SGTC_3126 9127922 49.47 µM 1.14194309845534 0.104554071842614 no 395 0.126738836242455 649 45595682
SGTC_461 N-acetylfarnesylcysteine 136 µM 1.14074190486703 0.104793604722082 no 396 0.126988671349967 614 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ).
SGTC_2054 5233173 129 µM 1.13301500902219 0.106343947515618 no 397 0.128603975215443 730 6889
SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM 1.13157656233147 0.106634380299832 no 398 0.128906249170267 760 551469
SGTC_2470 5664817 21.68 µM 1.13087298116863 0.10677664674064 no 399 0.129054278432263 685 2859561
SGTC_3201 9113999 49.47 µM 1.12453635126211 0.108064109102668 no 400 0.13039277909742 667 16649224
SGTC_85 0868-0259 160.055 µM 1.12106500846106 0.108774129227889 no 401 0.131130095924117 651 83173
SGTC_1283 0922-0125 16.4 µM 1.12008729459476 0.108974712587583 no 402 0.13133828216715 730 3360884
SGTC_2317 5986382 200 µM 1.11964820360581 0.109064880974285 no 403 0.131431852767642 714 877883
SGTC_2757 clomiphene 4.22 µM 1.11871624668652 0.109256438213452 no 404 0.131630605924918 779 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined.
SGTC_1131 3454-3128 32.3 µM 1.11834784474458 0.109332227283987 no 405 0.131709230088367 725 710982
SGTC_3310 9130229 44.1445 µM 1.11784312546118 0.109436121387834 no 406 0.131816999634248 673 7761258
SGTC_2899 9053889 58.44 µM 1.11649178453151 0.109714637628402 no 407 0.132105842430963 673 6470052
SGTC_1467 k284-1082 293 µM 1.11580155986564 0.10985709159014 no 408 0.132253542982255 742 3334705
SGTC_2457 5731572 11.68 µM 1.11570285538534 0.109877473836337 no 409 0.132274673964387 698 2865357
SGTC_2043 5101342 149 µM 1.11471657060508 0.110081288414891 no 410 0.132485948892333 680 678451
SGTC_405 ebelactone b 50 µM 1.11408622719331 0.110211690113776 no 411 0.132621098314982 715 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).
SGTC_315 k915-0449 187 µM 1.11358442028424 0.11031558012627 no 412 0.132728756613363 792 20970215 YNL149C PGA2
SGTC_81 0411-0046 9.971 µM 1.11254339409169 0.110531329630233 no 413 0.132952291630072 635 12925265
SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM 1.10884495909257 0.111300264740635 no 414 0.133748535779293 641 364106
SGTC_917 harmaline 728.087 nM 1.10666590443031 0.111755096975397 no 415 0.134219200918466 705 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7
SGTC_284 0988-0104 32.6 µM 1.10078173199804 0.112989933383766 no 416 0.1354958321469 732 4666532
SGTC_1880 MG-132 525 µM 1.09580822948118 0.114041228357786 no 417 0.136581353162751 652 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1
SGTC_847 0342-0274 5.54 µM 1.09370642080891 0.114487595234619 no 418 0.137041878662583 739 18097
SGTC_486 niguldipine 82 µM 1.09297670031729 0.114642858438684 no 419 0.137202014935701 647 1236 A calcium channel blocker.
SGTC_2798 7813637 45.45 µM 1.09210359132995 0.114828827352702 no 420 0.137393785538033 707 956368
SGTC_2842 9000675 19.48 µM 1.09022061030731 0.115230625444246 no 421 0.137807988284691 657 2989072
SGTC_1188 1403-0014 4.57 µM 1.08953419946106 0.115377342845303 no 422 0.137959191002928 777 9614867
SGTC_82 0054-0107 293.755 µM 1.08911913110859 0.115466126329331 no 423 0.138050677225476 705 3104697
SGTC_1568 digitonin 820 nM 1.08554166933495 0.11623336133428 no 424 0.138840909318172 762 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1
SGTC_1731 st035964 63 µM 1.08326485680806 0.116723534442109 no 425 0.139345439677783 693 6739575
SGTC_2705 st078069 42.8 µM 1.08260615057739 0.116865619716544 no 426 0.139491638058579 664 1530061
SGTC_1718 roemerine 11.9335 µM 1.08013024528722 0.117400777572445 no 427 0.140042092559471 745 235224 An aporphine alkaloid with mutagenic activity.
SGTC_3353 9151644 39.2805 µM 1.07799269094179 0.117864196046665 no 428 0.140518508976436 730 4909158
SGTC_1087 pterostilbene 9.05 µM 1.07638058932183 0.118214552297229 no 429 0.140878539896231 756 5281727 Similar to reservatol, lowers cholesterol.
SGTC_2103 5378138 10 µM 1.07322294788456 0.118902931412803 no 430 0.141585548445162 814 244142
SGTC_2104 5389443 200 µM 1.07162516703888 0.119252330975505 no 431 0.141944212359158 764 2244536
SGTC_32 0928-0142 34.1 µM 1.07039935148189 0.119520880697178 no 432 0.142219795539634 714 2244242
SGTC_1842 st055362 61.2 µM 1.07031954863345 0.119538378557701 no 433 0.142237749055923 767 676032
SGTC_2699 st077704 54.6 µM 1.06715808296114 0.120233027250066 no 434 0.142950228611083 726 645852
SGTC_1507 4075-3230 155 µM 1.0666660866048 0.120341385692925 no 435 0.143061323209963 662 659771
SGTC_360 0957-0399 1.01 µM 1.06639200971285 0.120401778862715 no 436 0.143123236078876 768 6752301 YPR165W RHO1
SGTC_3144 9087057 49.47 µM 1.06462781018175 0.120791033296785 no 437 0.143522194874835 717 17249618
SGTC_3087 9117406 49.47 µM 1.06184230901251 0.12140743037819 no 438 0.144153639469724 722 42546093
SGTC_2413 inermin 26.06 µM 1.05889047894328 0.12206304390035 no 439 0.144824830429726 770 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1
SGTC_2490 carminic acid 95.39 µM 1.05698350816203 0.122487909522053 no 440 0.145259557073023 656 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_1860 st056228 74.6 µM 1.05438186080072 0.123069218334623 no 441 0.145854061794359 717 688679
SGTC_2386 9075165 157.42 µM 1.0532866613039 0.123314505801477 no 442 0.146104815188315 741 16452277
SGTC_1117 retinoic acid 1.10837 µM 1.05324228329318 0.123324452183633 no 443 0.146114981937741 808 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR).
SGTC_3215 9129942 49.47 µM 1.05149458843658 0.123716607646106 no 444 0.146515746765924 706 17682944
SGTC_2868 9035608 32.47 µM 1.05117695362306 0.12378797359875 no 445 0.146588662930684 750 6462614
SGTC_382 3229-0966 23.2 µM 1.0488569445835 0.124310105523801 no 446 0.147121982095962 790 5722370
SGTC_2497 7-hydroxyflavone 100 µM 1.04768581715895 0.124574258967261 no 447 0.147391692067728 695 5281894
SGTC_2921 7974240 10.71 µM 1.04680442930147 0.124773318863722 no 448 0.147594893562489 736 2979074 YDR527W RBA50
SGTC_3195 9113082 49.47 µM 1.04665558296473 0.124806957473305 no 449 0.147629228179611 734 17018038
SGTC_2804 7954240 19.48 µM 1.04631032212548 0.124885009282474 no 450 0.147708890632514 801 828705
SGTC_1655 st012546 55.1 µM 1.04464618306442 0.125261693199791 no 451 0.148093263187467 727 720985 YLR208W SEC13
SGTC_2095 5432005 200 µM 1.04366432160269 0.12548431283364 no 452 0.148320361176857 716 783734
SGTC_606 k015-0008 38.6 µM 1.04355944111949 0.125508108931736 no 453 0.14834463309461 835 1970475
SGTC_1042 0350-0096 82 µM 1.04320803990175 0.125587860518802 no 454 0.148425975322782 722 3122515
SGTC_1996 st072960 66.8 µM 1.03557743482174 0.127328375349371 no 455 0.150199661869554 811 1719405
SGTC_993 3909-8757 62.7 µM 1.03498151682534 0.127465005094439 no 456 0.150338771556824 707 4288324 YLR208W SEC13
SGTC_3175 9106517 49.47 µM 1.031675177813 0.128224921524865 no 457 0.151112154696495 756 41468073
SGTC_2907 7721985 69.9 µM 1.03084312650094 0.128416651521294 no 458 0.151307195319749 746 3267881
SGTC_1475 4092-1048 11.7 µM 1.02877191476246 0.12889478589083 no 459 0.151793433607977 815 2881759
SGTC_2644 guaiazulene 100 µM 1.02734546393567 0.129224795884121 no 460 0.152128910754382 781 3515 A coloring agent.
SGTC_599 1935-0052 86.5 µM 1.02650287075678 0.129420005094151 no 461 0.152327305577206 790 9557311
SGTC_1719 st032227 49.2 µM 1.0261233058342 0.129508008166769 no 462 0.152416733041842 759 3125804
SGTC_2487 5918373 44.05 µM 1.02589452726296 0.129561071069025 no 463 0.152470651286766 821 2876279
SGTC_659 k018-0002 107 µM 1.02505739546796 0.129755363795833 no 464 0.152668053337151 801 6797879 YHR007C ERG11
SGTC_941 3237-0776 460 µM 1.02233422935813 0.130388787884011 no 465 0.153311368929865 754 760008
SGTC_3006 9075424 71.4286 µM 1.02010521892102 0.130908857959237 no 466 0.153839280943501 731 7465181
SGTC_3068 9116768 49.47 µM 1.01968424810418 0.131007239076884 no 467 0.153939117293553 717 41904888
SGTC_1558 st069300 45.6 µM 1.01872590564167 0.131231394732593 no 468 0.154166555177733 718 24208000
SGTC_695 3505-6186 243 µM 1.01724818033724 0.131577552550479 no 469 0.154517690572165 794 1819379
SGTC_1026 k007-1105 30.6 µM 1.01640966970323 0.131774254059114 no 470 0.154717171413792 830 7066794
SGTC_2281 7943571 200 µM 1.01633423231474 0.131791960435384 no 471 0.154735126232241 850 1244024
SGTC_2706 st078239 82.5 µM 1.01530044128526 0.132034773311135 no 472 0.154981317063698 792 15434492
SGTC_3273 9137859 49.47 µM 1.01471305477039 0.132172873764778 no 473 0.155121314649633 789 2377234
SGTC_1222 0366-0074 1.18 µM 1.01360275898943 0.132434187379373 no 474 0.155386170327645 846 286520
SGTC_1561 5-methoxyflavone 52.9 µM 1.01089602423225 0.133072721981952 no 475 0.156033098556795 757 94525
SGTC_569 4130-2812 160 µM 1.00410081682212 0.134685077956585 no 476 0.157665010882563 683 743552
SGTC_2444 5485484 36.41 µM 1.00203281686568 0.135178419614126 no 477 0.158163871714496 835 6790631
SGTC_2224 6650123 117.647 µM 1.00126758082564 0.135361287844326 no 478 0.158348730875218 770 2908370
SGTC_145 3737-0113 38.366 µM 1.00048877574309 0.135547572684365 no 479 0.158537013414385 906 6849351
SGTC_3100 9120536 49.47 µM 0.997766644524094 0.136200067362336 no 480 0.159196264033636 696 16421196
SGTC_1760 st045453 10.4495 µM 0.997541357114177 0.136254164886194 no 481 0.159250904878558 844 3323419 YIL048W NEO1
SGTC_1876 myriocin 605 nM 0.993979673231385 0.137111374166986 no 482 0.160116381768907 824 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1
SGTC_1990 st072050 59.8 µM 0.992430211756522 0.137485438870539 no 483 0.160493853677092 806 17233948
SGTC_3259 9138485 49.47 µM 0.988712453442814 0.138385804302764 no 484 0.161401924010488 877 17646153
SGTC_3083 9117465 49.47 µM 0.988370348735378 0.13846885655622 no 485 0.161485651827837 800 16420915
SGTC_438 sphingosine 6.67 µM 0.985469020265935 0.139174573272547 no 486 0.162196870707351 717 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes.
SGTC_2492 derrusnin 100 µM 0.984541031844689 0.13940081217911 no 487 0.162424783546323 744 1715307 Part of coumarin class of compounds.
SGTC_932 2857-0803 154 µM 0.984360997772679 0.139444732540183 no 488 0.162469023826415 869 674898
SGTC_2185 6113692 200 µM 0.984055035099287 0.139519395506793 no 489 0.162544226882458 758 874150
SGTC_1657 st012939 43.4 µM 0.983898244772416 0.139557667018923 no 490 0.162582773404169 782 24207257
SGTC_1970 st070122 35.8 µM 0.981321866934061 0.140187566907969 no 491 0.163217021343301 794 102928
SGTC_818 4072-2707 53.5 µM 0.979703985438819 0.140584109240539 no 492 0.163616129127724 797 882871
SGTC_3275 9138069 49.47 µM 0.97955800760558 0.1406199257799 no 493 0.163652170871107 817 17617007
SGTC_1294 1000-1494 117 µM 0.978285169347483 0.14093248673249 no 494 0.163966651430712 792 712797 YDL207W GLE1
SGTC_3151 9099821 49.47 µM 0.97671817536598 0.141317927972248 no 495 0.164354347266607 797 17174189
SGTC_1215 3852-0577 11.2 µM 0.97667960640396 0.141327423971649 no 496 0.164363897245701 909 2884876
SGTC_225 nsc-122657 1.016 µM 0.974647598118137 0.141828333039857 no 497 0.164867547260863 698 275685
SGTC_2226 7298446 200 µM 0.971004415859023 0.142729418507741 no 498 0.165773039804641 788 3283010
SGTC_636 0kpi-0074 126 µM 0.969210443551029 0.143174549240804 no 499 0.16622010071625 797 616434
SGTC_1209 2323-2347 50.3 µM 0.967650144259653 0.14356246136539 no 500 0.16660956251339 841 5412760
SGTC_2284 7945075 39.21 µM 0.966164373071771 0.143932503573951 no 501 0.166980968538786 922 1245402
SGTC_715 0868-0130 184 µM 0.965686836617692 0.144051574028919 no 502 0.167100454134929 821 2876258
SGTC_1487 3970-0795 2.82 µM 0.964079908713858 0.144452738281134 no 503 0.167502932361072 856 3765103
SGTC_3131 9127911 49.47 µM 0.961246473260597 0.145161928538146 no 504 0.168214127200573 799 45595681
SGTC_2916 7875993 68.79 µM 0.961128351840247 0.145191544340745 no 505 0.168243817902405 838 1299250
SGTC_146 3448-8650 53.125 µM 0.961083852702167 0.145202702369664 no 506 0.168255003967513 938 2891488 YIL048W NEO1
SGTC_3182 9108849 49.47 µM 0.959642698563756 0.145564379515869 no 507 0.168617535771666 868 17133045
SGTC_2539 epi(13)torulosol 80 µM 0.957733053580973 0.146044563229173 no 508 0.169098692407593 803 6708597
SGTC_2111 5486399 200 µM 0.956900855381083 0.14625415353868 no 509 0.169308649717141 878 689674
SGTC_115 0527-0192 112.043 µM 0.95663572121611 0.146320970366127 no 510 0.169375576194807 921 4233931
SGTC_2478 5763493 32.33 µM 0.956399820142582 0.146380437350918 no 511 0.169435137783481 865 1365576 YLR208W SEC13
SGTC_1101 ebselen 5.29 µM 0.956152888463385 0.146442702359564 no 512 0.169497498836464 914 3194 A potent scavenger of hydrogen peroxide and hydroperoxides.
SGTC_1710 st031758 61.5 µM 0.955525041601389 0.146601097026469 no 513 0.16965612395737 835 5394341
SGTC_2719 novobiocin 32.65 µM 0.95419486032999 0.146937057969011 no 514 0.169992507903206 810 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication.
SGTC_641 4092-0595 30 µM 0.953685556747681 0.147065828245889 no 515 0.170121416651018 871 786260
SGTC_1177 0983-0204 23.6 µM 0.95317249225092 0.147195625903742 no 516 0.170251340639487 899 766818
SGTC_773 4358-1457 44.6 µM 0.952598732276217 0.14734086954384 no 517 0.170396709898159 911 1186886
SGTC_392 N-ethylmaleimide 8.33 µM 0.948993553995197 0.148255694502166 no 518 0.171311945265467 817 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides.
SGTC_2940 9060638 45.86 µM 0.947488930846916 0.148638618734658 no 519 0.171694847033666 827 4027022
SGTC_2997 9067075 71.4286 µM 0.946838622139332 0.148804325742637 no 520 0.171860508946213 876 27209819
SGTC_1116 jasmonic acid 1.58368 µM 0.945919369353837 0.149038773683561 no 521 0.172094856670057 859 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid.
SGTC_3312 9133330 71.43 µM 0.94576251017695 0.149078803971254 no 522 0.1721348655875 923 17617324
SGTC_2480 5767542 37.17 µM 0.944241659973457 0.149467295608166 no 523 0.172523085431713 884 2867358
SGTC_2147 5545932 89.7195 µM 0.944227952932161 0.149470800055551 no 524 0.17252658689669 847 797404
SGTC_1396 3511-0007 98.6 µM 0.943065824942097 0.149768118055078 no 525 0.172823617392443 774 X1396
SGTC_292 k038-0015 474 µM 0.942650351302176 0.149874508203996 no 526 0.172929888128248 841 46368540
SGTC_345 1362-0200 395 µM 0.942508054258936 0.149910957729174 no 527 0.172966294740611 826 1419823
SGTC_2343 7990716 14.84 µM 0.942359738088049 0.149948955351273 no 528 0.173004246540373 874 6456862
SGTC_1502 4534-4282 27.7 µM 0.941689986466289 0.150120621264958 no 529 0.173175691618984 839 3278949
SGTC_2746 daunorubicin 9.88 µM 0.94146343745595 0.150178718317203 no 530 0.173233708813106 751 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_986 1493-0483 84 µM 0.940917942516764 0.150318668502421 no 531 0.173373456007476 844 40079
SGTC_3278 9139605 49.47 µM 0.940086836819074 0.150532060961074 no 532 0.173586510096195 840 7958859
SGTC_68 0986-0284 82.829 µM 0.937027380947461 0.151319336461972 no 533 0.174372236823211 709 423278 YIL048W NEO1
SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM 0.935338460637148 0.151755109474424 no 534 0.174806950219845 870 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair.
SGTC_1172 0370-0043 85 µM 0.934147251176964 0.152062964821759 no 535 0.175113970492177 879 376585
SGTC_1609 st001574 46.4 µM 0.931537288651551 0.152738930736272 no 536 0.175787852627234 881 3960012
SGTC_887 0885-0007 9.62 µM 0.931089056811936 0.152855220539948 no 537 0.17590374940528 888 5719458
SGTC_3224 9130643 49.47 µM 0.930704970520171 0.152954915044245 no 538 0.176003098920198 836 17644395
SGTC_1347 1493-0251 600 nM 0.930394482569426 0.153035537661922 no 539 0.176083437115395 941 3986378
SGTC_1281 0884-0031 11.8 µM 0.929017433193605 0.153393447616562 no 540 0.176440025890591 881 1548255
SGTC_2584 androsterone 48.74 µM 0.928854955031127 0.153435713982563 no 541 0.176482129936914 1015 2754130 A steroid.
SGTC_1075 aripiprazole 15.2 µM 0.927557641477989 0.153773468193318 no 542 0.176818539346369 927 60795 An atypical antipschotic. YIL048W NEO1
SGTC_677 0929-0063 136 µM 0.927138114835656 0.153882796740838 no 543 0.176927414457493 813 1539583
SGTC_666 0272-0154 136 µM 0.925728416049942 0.154250540682954 no 544 0.177293568267411 877 6870312
SGTC_3143 9086658 49.47 µM 0.924930054685944 0.154459064415472 no 545 0.177501145961327 931 25236626
SGTC_1656 st012921 11 µM 0.924874034322784 0.154473703348573 no 546 0.177515717275646 824 6732821
SGTC_35 0133-0054 64.071 µM 0.924600912920606 0.15454508706622 no 547 0.177586769002693 823 99677
SGTC_2832 7992762 51.95 µM 0.923976900225365 0.154708262443342 no 548 0.177749171399475 753 2985177
SGTC_656 4090-1979 187 µM 0.922889348364605 0.154992922380657 no 549 0.178032436027446 951 22330961
SGTC_2957 9076800 11.52 µM 0.921850381568926 0.155265188332909 no 550 0.178303311826245 791 16459615
SGTC_1741 st038134 10.228 µM 0.920381471496943 0.155650661202291 no 551 0.178686723828631 943 1272587
SGTC_605 1315-0399 119 µM 0.919969413672667 0.15575890710102 no 552 0.178794371515151 920 24020461
SGTC_2179 6298986 200 µM 0.918258320176849 0.156208935261448 no 553 0.179241821253126 862 738374
SGTC_1434 4073-0095 163 µM 0.916561456681696 0.156656065989659 no 554 0.179686244700918 932 24133745
SGTC_1653 st012112 65 µM 0.916068289282286 0.156786175542077 no 555 0.179815539318935 845 720429
SGTC_2107 5363541 170.161 µM 0.913934032316311 0.157350064006778 no 556 0.18037575492113 928 244052
SGTC_3073 9114972 49.47 µM 0.913850362268208 0.157372197453212 no 557 0.180397739539807 823 41905075
SGTC_1268 0828-0275 2.46 µM 0.913624362250156 0.157431992030417 no 558 0.180457130294063 940 745337
SGTC_1350 1495-0454 146 µM 0.912574486182121 0.157709961664378 no 559 0.18073318901101 933 1069057
SGTC_894 0960-0238 55.9 µM 0.909575642351852 0.15850572286476 no 560 0.181523174534194 930 6741907 YDL195W SEC31
SGTC_181 1447-1644 8.07 µM 0.907407075177197 0.159082803048101 no 561 0.182095784672571 913 534600
SGTC_2623 humulene 100 µM 0.907304096087982 0.159110241135709 no 562 0.182123004355199 762 6187145 An anti-inflammatory.
SGTC_2675 theaflavin digallate 100 µM 0.906946670189656 0.159205498921438 no 563 0.182217499768679 923 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative.
SGTC_3160 9100216 49.47 µM 0.906877205831471 0.159224016242496 no 564 0.18223586814714 914 17191039
SGTC_212 3807-4682 38.772 µM 0.905944544731414 0.159472775101251 no 565 0.182482602686924 1049 3125501 YBL034C STU1
SGTC_2372 9071633 200 µM 0.90449245530938 0.159860581733032 no 566 0.18286716658633 972 21321366
SGTC_2735 sertaconazole 140 nM 0.903596298576413 0.160100224104609 no 567 0.183104752349365 887 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C
SGTC_574 1315-0397 40 µM 0.898519474186488 0.161462255881622 no 568 0.184454333861684 1019 6794277
SGTC_6 0844-0013 19.835 µM 0.897117931230637 0.161839594685084 no 569 0.18482799571746 1102 1584900
SGTC_632 0781-2353 4.65 µM 0.896425250659451 0.162026297756189 no 570 0.185012843146403 945 6811515 YHR007C ERG11
SGTC_1141 3253-0389 52.6 µM 0.894662573788284 0.162502036925481 no 571 0.185483745555835 920 5402031
SGTC_3148 9097893 49.47 µM 0.894556051627303 0.162530815910297 no 572 0.185512226966108 889 17174100
SGTC_2703 st077852 53.4 µM 0.893032485355154 0.162942799176654 no 573 0.185919888170299 882 6281836
SGTC_2152 5568786 200 µM 0.88916500792058 0.163991639264058 no 574 0.186957202833344 906 5399883
SGTC_1946 st076057 65.1 µM 0.888634077791346 0.164135965977104 no 575 0.187099885163958 810 953009
SGTC_3230 9131665 49.47 µM 0.887553983933159 0.164429830179163 no 576 0.18739035774161 854 15943720
SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM 0.886616234601946 0.164685242720302 no 577 0.187642775159971 829 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding.
SGTC_3295 9122362 53.5725 µM 0.885508076168539 0.164987400355158 no 578 0.187941332865266 876 4730473
SGTC_3032 9089427 49.47 µM 0.883526286967628 0.16552866222261 no 579 0.188475993095471 906 17173707
SGTC_895 0964-0006 13.7 µM 0.882174623201436 0.165898483681751 no 580 0.188841191404705 930 6738897
SGTC_1478 0453-0656 35.7 µM 0.878133002890876 0.167007472689971 no 581 0.189935772386122 960 5258496
SGTC_2162 5663267 200 µM 0.874007086188029 0.168144511669449 no 582 0.191057197350777 977 6456493
SGTC_1912 st060209 90.8 µM 0.871114112841758 0.16894473402765 no 583 0.191845924525915 900 688787
SGTC_1859 st055998 20 µM 0.869812728571973 0.169305505040038 no 584 0.19220137714693 979 676301
SGTC_349 k015-0014 24 µM 0.869729080297444 0.169328710998535 no 585 0.192224238127535 884 2196908
SGTC_3208 9114115 49.47 µM 0.868349417951109 0.16971175563223 no 586 0.192601538234612 852 650895
SGTC_2482 5981709 142.65 µM 0.866912404231469 0.17011131350786 no 587 0.192995003258809 932 877755
SGTC_863 0466-0191 129 µM 0.866175246410836 0.170316512048249 no 588 0.19319703288866 985 765160 YPR165W RHO1
SGTC_649 1123-0311 367 µM 0.865445378087761 0.17051983760071 no 589 0.19339719184876 976 693629 YIL048W NEO1
SGTC_3165 9101544 49.47 µM 0.865143999241014 0.170603840560413 no 590 0.193479878825785 967 5002184
SGTC_627 1391-0720 175 µM 0.86497514359322 0.170650917068125 no 591 0.193526215865277 923 997839
SGTC_2690 usnic acid 100 µM 0.864930105217553 0.170663475052765 no 592 0.193538576352425 996 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_1985 st071382 65.5 µM 0.862324489863087 0.171391001964887 no 593 0.194254489950922 1005 6123237
SGTC_680 0417-1641 114 µM 0.860365870170976 0.17193918114493 no 594 0.194793696621831 894 2835990
SGTC_3024 9090631 49.47 µM 0.859582351137376 0.172158785866299 no 595 0.195009653571165 933 25236383
SGTC_1627 st003713 25.6 µM 0.858637553614031 0.172423831675699 no 596 0.195270256302464 1017 16195070 YER133W GLC7
SGTC_1060 3448-7350 82 µM 0.858617266342249 0.172429525754733 no 597 0.195275854443785 936 570178
SGTC_1962 st076595 64.5 µM 0.858150794642465 0.172560484610309 no 598 0.195404601187279 966 279619
SGTC_2305 7443522 69.23 µM 0.85748298892094 0.172748077027168 no 599 0.195589006080591 980 5415886
SGTC_779 1360-0071 233 µM 0.856643986374759 0.172983944292295 no 600 0.195820834213179 1021 7566
SGTC_564 3555-0129 330 µM 0.85349635371295 0.173870660296075 no 601 0.196692054424975 883 563260
SGTC_2874 9043904 71.43 µM 0.850341353341504 0.174762347221421 no 602 0.197567665819773 871 4463428
SGTC_309 k408-0051 1.48 µM 0.849735627491815 0.174933873020337 no 603 0.197736042941427 998 3640463
SGTC_2049 5262831 67.185 µM 0.848873928677714 0.1751780677181 no 604 0.197975723722981 971 763417
SGTC_2188 6126565 140.678 µM 0.848316009515275 0.175336290301636 no 605 0.198131001998641 941 874518
SGTC_1833 st055984 71 µM 0.846205462998951 0.175935648213376 no 606 0.198719067443352 942 676288
SGTC_1290 0986-0249 10.2 µM 0.844572605137885 0.176400240070076 no 607 0.199174754900359 973 53329
SGTC_336 4111-0029 111 µM 0.844470653830985 0.176429273672039 no 608 0.199203227676035 922 3131175
SGTC_219 mitoxanthrone 164.414 µM 0.844042202401247 0.176551320731054 no 609 0.199322911610493 922 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA. YMR168C CEP3
SGTC_1239 0337-0584 35.4 µM 0.843312600033159 0.176759275360419 no 610 0.199526818887538 1028 914301 YML130C ERO1
SGTC_1491 4138-0063 26.5 µM 0.842774590948033 0.176912720339489 no 611 0.199677260591225 982 23883227
SGTC_2980 9014342 25.29 µM 0.840444427010444 0.177578275286883 no 612 0.200329624156237 896 2996599
SGTC_1631 benzylvanillin 81.9 µM 0.838714364621206 0.17807344652145 no 613 0.200814807767412 965 75506
SGTC_1039 k821-0043 94 µM 0.836976493548163 0.17857172823202 no 614 0.201302890570359 1009 15992768
SGTC_1384 3089-0840 101 µM 0.836793375631784 0.17862428281863 no 615 0.201354360799554 947 1069836
SGTC_381 3461-2219 42.7 µM 0.836708567520108 0.17864862592812 no 616 0.201378201079082 1008 2883159
SGTC_415 dibenzyl ketone 100 µM 0.830659289030161 0.180390382301368 no 617 0.20308306545513 993 7593
SGTC_3345 9148410 3.559 µM 0.826428100153753 0.181614970013233 no 618 0.204280644334083 985 4903596
SGTC_1691 st019933 84.6 µM 0.826373508661817 0.181630803761742 no 619 0.204296123118937 1006 6176082
SGTC_2843 9000894 45.46 µM 0.826309029537223 0.181649506437709 no 620 0.204314406326918 894 2242070
SGTC_760 0568-0725 82.9 µM 0.825111320884885 0.18199713029297 no 621 0.204654196522426 1038 3916171
SGTC_930 2810-3379 265 µM 0.823679156074185 0.182413348562314 no 622 0.205060943012543 1062 1015764
SGTC_721 1187-1332 279 µM 0.821663198120571 0.183000236601167 no 623 0.205634304996485 904 25730
SGTC_524 r073-0010 27.8 µM 0.821399993600412 0.183076947868947 no 624 0.205709233603784 959 2772106
SGTC_1352 1496-0991 99 µM 0.820697392096503 0.183281820137933 no 625 0.205909328325378 1032 3000039
SGTC_1008 4106-0037 6 µM 0.820374020043285 0.183376160538718 no 626 0.206001460623835 1004 2905394
SGTC_1818 st052136 56.3 µM 0.819884555006333 0.183519014405608 no 627 0.206140961163912 960 674169
SGTC_489 paxilline 115 µM 0.817608397707288 0.184184238040839 no 628 0.206790415420047 999 105008 A toxic potassium channel blocker.
SGTC_1453 4237-0541 195 µM 0.816486175055481 0.184512767501419 no 629 0.207111063700712 1032 739892
SGTC_1611 st001856 99.4 µM 0.816044897186687 0.184642050890316 no 630 0.207237228819593 982 647478
SGTC_3041 9091929 49.47 µM 0.815276639129393 0.184867265657088 no 631 0.207456988789097 1088 25236887
SGTC_901 1112-0062 60.1 µM 0.814695920122939 0.185037616619421 no 632 0.207623194650036 1030 1908457
SGTC_1871 st057448 67.3 µM 0.811246845469031 0.186051393626293 no 633 0.208611964230259 1046 691747
SGTC_2793 7325131 81.82 µM 0.808965282968188 0.18672389543844 no 634 0.209267557951182 989 4176441
SGTC_1875 nocodazole 6 µM 0.808661818286778 0.186813456396948 no 635 0.209354848048042 1039 4122 A microtubule depolymerizer. YJL014W CCT3
SGTC_2326 6164455 177.58 µM 0.808469879433442 0.186870116671912 no 636 0.20941006935914 977 2888790
SGTC_15 0266-0086 27.098 µM 0.807067234214106 0.187284499747588 no 637 0.209813874159126 1128 1712902 YIL048W NEO1
SGTC_1905 st060207 84.5 µM 0.806579294287528 0.187428784794105 no 638 0.209954453477135 1003 1948547
SGTC_1348 1493-0373 93.8 µM 0.806240854206295 0.187528902708898 no 639 0.210051993221092 1018 3010129
SGTC_2941 9056145 11.23 µM 0.806115448327206 0.187566008877317 no 640 0.210088142441055 955 2119517
SGTC_3200 9114385 49.47 µM 0.805742519336154 0.187676381113061 no 641 0.210195663715551 1005 17018030 YLR208W SEC13
SGTC_2677 mitomycin C 100 µM 0.804752586141516 0.187969556751828 no 642 0.210481233692591 1031 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_3344 9148862 3.898 µM 0.803633495580397 0.188301323527168 no 643 0.210804336273358 1054 4905352
SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM 0.802445120705738 0.188654025632399 no 644 0.211147760804474 1009 756377
SGTC_3037 9091026 49.47 µM 0.801240781172795 0.18901188115009 no 645 0.211496133188413 1106 25236398 YIL048W NEO1
SGTC_159 3970-0959 50 µM 0.800995601212094 0.18908478472516 no 646 0.211567096198895 1187 6615653
SGTC_297 0986-0032 24 µM 0.794799117605217 0.190933037541694 no 647 0.213365182185486 1029 2847425
SGTC_706 4262-0057 46.9 µM 0.794030382617757 0.191163101777864 no 648 0.21358887200335 1052 883298
SGTC_2240 6690706 185.951 µM 0.793618486160016 0.191286442567721 no 649 0.213708783608725 935 805876
SGTC_940 3232-1287 54.8 µM 0.789954146347349 0.192385860880247 no 650 0.214777273846027 1054 1585493 YIL048W NEO1
SGTC_1090 efavirenz 20.7 µM 0.785746891760275 0.19365292502928 no 651 0.21600789283363 1050 64139 A non-nucleoside reverse transcriptase inhibitor.
SGTC_2116 5511452 16.8835 µM 0.785540925084591 0.193715084690043 no 652 0.216068242636306 1045 870744
SGTC_2607 solasodine 47.35 µM 0.783373805336384 0.19436984716622 no 653 0.216703816919091 1063 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity.
SGTC_436 n,n-dimethylsphingosine 3.3 µM 0.783207129974327 0.194420261346254 no 654 0.216752744314295 1168 5282309
SGTC_2755 lomerizine 42.69 µM 0.780951601894417 0.195103271806983 no 655 0.217415480316032 1101 3949 A calcium channel blocker.
SGTC_560 2332-1943 155 µM 0.780080701517387 0.19536738437597 no 656 0.21767168747079 1063 21177716
SGTC_1531 st059297 52.4 µM 0.778837910935704 0.195744653687386 no 657 0.218037601215594 1071 7566702
SGTC_720 r052-1644 49.9 µM 0.773538904061839 0.197358209791983 no 658 0.219601756932544 1006 1422863 YOR257W CDC31
SGTC_2713 st079149 53.4 µM 0.773184545554795 0.197466398726575 no 659 0.219706585509797 1067 3103253
SGTC_2090 5301565 104.445 µM 0.77291710260469 0.197548075277603 no 660 0.219785721197915 1092 2056344
SGTC_2165 5727197 32.143 µM 0.772729445194853 0.197605397672785 no 661 0.219841258314927 1117 1361712
SGTC_933 2914-0560 114 µM 0.771394810053324 0.19801336928894 no 662 0.220236475205243 1135 463887
SGTC_298 1391-0729 10 µM 0.770795044019398 0.198196871464625 no 663 0.220414212644894 1067 3237558
SGTC_2337 9009472 200 µM 0.770014592988074 0.198435808993611 no 664 0.220645618163244 1084 5742383
SGTC_811 0416-0114 265 µM 0.769264219575085 0.198665701967548 no 665 0.220868236768296 1071 6612453
SGTC_788 1182-0090 188 µM 0.768893259426684 0.198779412861006 no 666 0.220978339631712 1149 5715185
SGTC_1077 5-fluorocytosine 377 nM 0.7653662334087 0.199862515614241 no 667 0.222026747038831 1050 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_535 2293-4129 48.2 µM 0.764523043630553 0.200121972705388 no 668 0.222277804881014 1139 396118 YIL048W NEO1
SGTC_11 0438-0307 1.3 µM 0.76363024805054 0.200396914504272 no 669 0.222543809196831 1081 4011476
SGTC_1608 st001473 40.5 µM 0.763495504006616 0.200438429445695 no 670 0.222583971319992 1040 7292267
SGTC_2245 6637752 200 µM 0.763233731889436 0.200519096785557 no 671 0.22266200753697 1048 681890
SGTC_2534 helenine 20.12 µM 0.763207332981569 0.200527232919202 no 672 0.222669878113503 1078 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58
SGTC_554 4483-2211 187 µM 0.761596908830521 0.201023939896429 no 673 0.223150310159893 1052 747107
SGTC_1645 Cervolide 78 µM 0.760326534778455 0.201416284637242 no 674 0.223529712313084 1045 23173 A fragrance.
SGTC_2300 7976697 71.57 µM 0.759653235203772 0.201624413703211 no 675 0.223730944522109 996 2236109
SGTC_2042 p-Dimethylaminoacetophenone 200 µM 0.759387077154097 0.201706723483492 no 676 0.223810520824174 1085 75037 A free radical scavenger.
SGTC_1702 st027038 51 µM 0.75760545869451 0.202258209733028 no 677 0.224343605668197 1116 5521182
SGTC_2551 apiole 73.87 µM 0.757330618830711 0.202343364521617 no 678 0.224425905672929 984 10659 A possible DNA adduct former.
SGTC_759 3486-0358 89.3 µM 0.75718282801314 0.202389164034595 no 679 0.224470168290472 1132 875103
SGTC_2021 4019055 173 µM 0.755680436652734 0.202855098088015 no 680 0.224920408111882 1135 44827708 YER133W GLC7
SGTC_2157 5649910 96.377 µM 0.753292946895116 0.2035968430216 no 681 0.225636948104828 1098 2858091
SGTC_83 0170-0301 39.027 µM 0.748117364990708 0.205210335255163 no 682 0.227194684349617 1071 3089716
SGTC_2051 5263410 176 µM 0.746606138713294 0.205682890616717 no 683 0.227650670909528 1198 227584
SGTC_2119 5528445 120.635 µM 0.745381141858104 0.206066416534671 no 684 0.228020670440937 1107 791935
SGTC_1711 st032263 62.8 µM 0.745232697010207 0.2061129209115 no 685 0.228065529868071 1100 3958979
SGTC_3128 9127691 49.47 µM 0.743635407027181 0.206613708941729 no 686 0.228548538295738 1022 41316314
SGTC_3132 9126706 49.47 µM 0.740884260820417 0.207477945597524 no 687 0.229381809696994 1121 850858
SGTC_1954 st077032 68.9 µM 0.739978207772156 0.207763037382604 no 688 0.229656608746497 1075 698907
SGTC_566 0958-0068 16.5 µM 0.738656503499215 0.208179329535931 no 689 0.230057802166953 1102 6815365
SGTC_346 4513-0042 7.16 µM 0.736768897456403 0.20877471429212 no 690 0.230631450211859 1103 2827372
SGTC_201 4262-0159 12.803 µM 0.736189489337307 0.208957671070071 no 691 0.230807693922617 1087 1341029
SGTC_2889 9059656 51.95 µM 0.733780904135421 0.209719229498458 no 692 0.231541140334553 1176 3949838
SGTC_886 0866-0150 153 µM 0.731867155682804 0.210325489837105 no 693 0.232124827407457 1166 271463
SGTC_1032 k061-1018 98.7 µM 0.730600022737113 0.210727473138184 no 694 0.232511749073417 1218 4005393
SGTC_1126 isoteolin 1.0172 µM 0.728803137440797 0.211298286274444 no 695 0.233061046063068 1157 133323
SGTC_517 1365-0151 113 µM 0.727397626226745 0.211745403030731 no 696 0.233491204119443 1161 768657
SGTC_2564 betulinic acid 100 µM 0.726365347483605 0.212074140625504 no 697 0.233807414295753 1184 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14
SGTC_1152 3909-8331 15.9 µM 0.72524528995802 0.212431169451261 no 698 0.234150781378441 1142 16001939
SGTC_1262 0737-0114 49.6 µM 0.724035011446034 0.212817351523688 no 699 0.234522120437514 1193 765919
SGTC_3101 9120531 49.47 µM 0.723828485253984 0.212883291901461 no 700 0.234585519566324 1173 24824904
SGTC_783 0848-0141 92.7 µM 0.723638117360783 0.212944083763304 no 701 0.2346439668375 1131 6755076 YHR007C | YLR033W ERG11 | RSC58
SGTC_3225 9130819 49.47 µM 0.722740902673586 0.213230735611992 no 702 0.234919540532875 1147 4547121
SGTC_2824 7998404 51.95 µM 0.722225599516556 0.213395471918077 no 703 0.235077893390543 1103 837851
SGTC_1414 3917-0015 5.4 µM 0.721295553554848 0.213692984290861 no 704 0.235363846055714 1143 6618702
SGTC_2977 9011197 71.43 µM 0.721082585026038 0.213761144769563 no 705 0.235429352533273 1105 2704722
SGTC_916 4466-0038 42 nM 0.72098456181978 0.213792521305979 no 706 0.235459506636533 1209 5722064 YGL116W CDC20
SGTC_1145 3546-0597 10.2 µM 0.719498675592217 0.214268471383884 no 707 0.235916858980564 1129 875334
SGTC_1902 st060212 70.5 µM 0.718128363832749 0.214707947173492 no 708 0.236339071397689 1196 688944
SGTC_505 gw-5074 63.9 µM 0.716684438337373 0.215171598066535 no 709 0.236784415022424 1145 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases.
SGTC_3255 9139072 49.47 µM 0.716449441242274 0.215247111630123 no 710 0.236856937788606 1186 17646060
SGTC_955 1216-0110 33 µM 0.716055121617185 0.215373856172506 no 711 0.236978656727809 1131 3619719
SGTC_2770 toltrazuril 17.5 µM 0.715590754859115 0.215523171184644 no 712 0.237122041952874 1163 68591 Kills coccidiodes.
SGTC_1508 1080-0625 72.9 µM 0.715355553837797 0.215598821899761 no 713 0.237194684522373 1112 767111
SGTC_2433 5607874 27.82 µM 0.71470431882659 0.215808367276632 no 714 0.237395884259282 1179 2252428
SGTC_3265 9137266 49.47 µM 0.714481820335849 0.215879986802223 no 715 0.237464646870569 1122 17224265
SGTC_2243 6634756 200 µM 0.71389564122269 0.216068736571758 no 716 0.237645856418487 1188 885676
SGTC_1969 st069479 40.1 µM 0.713842727812011 0.216085779401052 no 717 0.237662217634833 1139 3895485
SGTC_1751 st044839 27.194 µM 0.712267507380783 0.216593497124125 no 718 0.238149570345787 1174 5291326
SGTC_2271 7849410 118.62 µM 0.71075021160189 0.217083196712909 no 719 0.238619519227938 1172 972430
SGTC_816 0325-0417 81.3 µM 0.710255944505799 0.217242856970713 no 720 0.238772717074559 1176 68101
SGTC_593 1203-0218 61.7 µM 0.710149391710484 0.217277284992085 no 721 0.238805750110328 1215 3666956
SGTC_1897 st060201 15 µM 0.70982359279496 0.217382572653516 no 722 0.238906768383454 1171 611878
SGTC_248 streptozotocin 5.23457 mM 0.709168347283649 0.217594415967599 no 723 0.23911000668382 1206 5300 DNA alkylating agent.
SGTC_2528 xanthyletin 44.79 µM 0.708287127658049 0.21787950532548 no 724 0.239383484589202 1207 65188 An natural product with antifungal activity of unknown mechanism.
SGTC_96 0929-0093 37.281 µM 0.707481356536834 0.218140374258125 no 725 0.239633697234286 1141 6991579
SGTC_3334 9142812 21.919 µM 0.706609583520245 0.218422813979201 no 726 0.239904565850029 1170 45283678
SGTC_777 1315-0167 517 µM 0.705855180730134 0.218667397634847 no 727 0.240139101076451 1147 4221767
SGTC_1843 st055809 45.5 µM 0.705408384747083 0.218812326906611 no 728 0.240278063759927 1160 16413835
SGTC_1055 3448-0672 86 µM 0.705304727883205 0.218845958458441 no 729 0.240310309424075 1157 748378
SGTC_266 formosanin C 406 nM 0.705268135795261 0.218857831500671 no 730 0.240321693084508 1167 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1
SGTC_2792 7535235 81.82 µM 0.70506639275797 0.218923297758877 no 731 0.240384459856537 1153 1281891
SGTC_1420 4'-methoxyflavone 42 µM 0.704228648364283 0.219195268966051 no 732 0.240645196383558 1182 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13
SGTC_1988 st071872 53.4 µM 0.70384852424339 0.219318739155994 no 733 0.240763555591027 1195 16414116
SGTC_216 k038-0035 28.382 µM 0.703483818646241 0.219437238733068 no 734 0.240877143704801 1137 4444231 YPR107C YTH1
SGTC_5 0352-0601 109.883 µM 0.701986714175378 0.219924060854081 no 735 0.241343724481935 1110 762456
SGTC_2847 9005661 71.43 µM 0.701958240080917 0.219933325942037 no 736 0.241352603344818 1095 2991449
SGTC_3089 9117425 49.47 µM 0.701241685601065 0.220166556877053 no 737 0.241576099560639 1148 9401657
SGTC_2215 7188065 200 µM 0.701128683555642 0.220203350796894 no 738 0.241611355607427 1194 940217
SGTC_2068 5226020 147 µM 0.700014729997104 0.220566247211293 no 739 0.241959052747251 1225 1810509
SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM 0.699949435832124 0.220587528937762 no 740 0.241979441362799 1197 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_1057 3448-5381 134 µM 0.699816018927124 0.220631017983114 no 741 0.242021104735901 1208 5497911
SGTC_1855 st056195 39.6 µM 0.6984286187011 0.221083550873285 no 742 0.242454591971727 1161 4028379
SGTC_3145 9085516 49.47 µM 0.696557850611129 0.221694585570043 no 743 0.243039770720802 1204 25236195
SGTC_1356 1502-0781 85.8 µM 0.695137771222172 0.222159058790689 no 744 0.243484482947867 1166 567702
SGTC_256 clotrimazole 625 nM 0.694192943732102 0.222468396179015 no 745 0.243780608589355 1179 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C
SGTC_421 streptovitacin 30 mM 0.69409109504621 0.222501756192604 no 746 0.243812541371489 1213 91467 include heat shock
SGTC_2912 7964298 10.93 µM 0.693572112561235 0.222671790534087 no 747 0.243975293840039 1232 2975850
SGTC_2088 5278280 127.392 µM 0.693571924606274 0.222671852127224 no 748 0.243975352793171 1237 791502
SGTC_1913 st060213 96.1 µM 0.692127051863235 0.223145626104076 no 749 0.244428772292686 1212 688959
SGTC_823 0417-1665 178 µM 0.691958492304103 0.223200934164693 no 750 0.24448169799151 1223 3429856
SGTC_1329 1447-1697 50.6 µM 0.691375114780615 0.223392413258967 no 751 0.24466491925375 1187 2840515
SGTC_674 0498-0004 451 µM 0.691316513792089 0.223411652733651 no 752 0.244683328140338 1177 4231473
SGTC_3062 9077494 49.47 µM 0.69026922589626 0.223755650054796 no 753 0.245012448393002 1169 16459633
SGTC_1297 1068-0111 14.1 µM 0.689942414103861 0.223863057869315 no 754 0.245115200862779 1182 767057
SGTC_2655 perillic acid 100 µM 0.689328386338115 0.224064939421364 no 755 0.245308319193612 1192 5702197 An apoptosis inducer.
SGTC_1134 3477-0009 42.5 µM 0.688856526596241 0.224220148869529 no 756 0.245456779709932 1239 3973534
SGTC_1386 3228-0095 33.8 µM 0.687554372330869 0.224648784737901 no 757 0.245866724855073 1189 870181
SGTC_532 1548-0774 215 µM 0.686769123495807 0.224907493055968 no 758 0.246114114962802 1297 5932993
SGTC_1527 coumarin 137 µM 0.686319131104305 0.225055823773032 no 759 0.246255943765834 1223 323 A hepatotoxic, DNA x-linker.
SGTC_385 1494-0393 12.4 µM 0.685651977182093 0.225275839294768 no 760 0.246466298255576 1222 3090647
SGTC_1465 k213-0056 144 µM 0.685394014180441 0.225360943558943 no 761 0.246547660126468 1133 24048857 YMR208W ERG12
SGTC_2234 tolnaftate 200 µM 0.684570771209507 0.225632660373046 no 762 0.246807408247367 1195 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7
SGTC_970 1315-0089 19.5 µM 0.684297442934763 0.225722915160126 no 763 0.246893680669256 1164 6811083 YLR033W RSC58
SGTC_626 0214-0009 33 µM 0.683915020672723 0.225849227767574 no 764 0.247014414236171 1233 3437874
SGTC_352 k048-0007 5.11 µM 0.682454016987144 0.226332159583828 no 765 0.24747595473754 1204 6811911
SGTC_950 1165-0508 94.1 µM 0.679671334968767 0.227253581004072 no 766 0.248356295097984 1196 6148369
SGTC_357 1325-0123 420 µM 0.679364214990285 0.227355406123002 no 767 0.248453558982342 1204 1098503
SGTC_984 1492-0255 2.91 µM 0.678785438031113 0.227547368510553 no 768 0.248636910896671 1167 1585198
SGTC_1310 1188-0297 994 nM 0.678398448021173 0.227675772007486 no 769 0.248759546432029 1181 1588352
SGTC_156 3474-0145 5.642 µM 0.67747929007804 0.227980912549866 no 770 0.249050952834345 1171 2265471
SGTC_2641 levomentholum 100 µM 0.67536288110498 0.228684388447688 no 771 0.249722621172203 1190 16666
SGTC_2202 7226349 200 µM 0.674780328807079 0.228878237463463 no 772 0.249907669974484 1185 844334
SGTC_1734 st037168 69.4 µM 0.673159314500041 0.229418128213619 no 773 0.25042297092223 1222 708907
SGTC_261 5-fluorouridine 15.376 µM 0.67305029197631 0.22945446456699 no 774 0.250457648070859 1255 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_2383 9036125 200 µM 0.672988346795547 0.229475111847446 no 775 0.250477352309603 1184 79580
SGTC_1687 st020778 55.3625 µM 0.672764966270817 0.229549576654548 no 776 0.250548414589512 1236 4259299
SGTC_602 3130-1533 38.1 µM 0.672484118515461 0.229643217605012 no 777 0.250637773619902 1245 720941
SGTC_2083 5306046 65.942 µM 0.672245025910064 0.229722953309614 no 778 0.250713860462498 1258 539837
SGTC_867 0518-0118 155 µM 0.672024939274959 0.229796364359709 no 779 0.250783909813856 1267 6848158
SGTC_1832 st054113 55 µM 0.670823676318785 0.230197283341794 no 780 0.251166431320814 1219 1251267
SGTC_1308 1187-1617 41.4 µM 0.670469128239218 0.230315687754351 no 781 0.251279390005394 1240 2882570
SGTC_2648 atorvastatin 78.68 µM 0.669033017279739 0.230795637678832 no 782 0.251737208216406 1249 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11
SGTC_1690 st023502 41.2 µM 0.668430717685381 0.230997093034604 no 783 0.251929346490367 1220 24207482
SGTC_507 nimesulide 162 µM 0.668216823345584 0.231068659382458 no 784 0.251997599073978 1281 4495 A COX2 inhibitor.
SGTC_657 3534-0529 86.7 µM 0.668003572508145 0.23114002273992 no 785 0.252065656031204 1275 1049549
SGTC_2813 7971799 71.43 µM 0.667665644848941 0.231253133772608 no 786 0.252173522253668 1267 2234054
SGTC_2336 9001819 198.65 µM 0.666574070148358 0.231618716177442 no 787 0.252522118232986 1304 2989602
SGTC_319 1348-1596 45.5 µM 0.665910019071074 0.231841272906867 no 788 0.252734308062385 1300 5380505
SGTC_1360 1598-0022 39.8 µM 0.665762033173752 0.231890886608656 no 789 0.252781608031394 1272 761525
SGTC_2762 leflunomide 42.06 µM 0.66450557844835 0.232312363346063 no 790 0.253183389875244 1245 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1
SGTC_129 0088-0017 176.636 µM 0.664206342090301 0.232412804745602 no 791 0.253279127445014 1176 182446
SGTC_112 phenothiazine 287.218 µM 0.6630633028098 0.232796698518077 no 792 0.253645006152035 1238 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.
SGTC_108 0509-0257 621.132 µM 0.662818146858462 0.232879080873551 no 793 0.253723514958847 1237 536624
SGTC_1100 amiodarone 5.07 µM 0.662455542422315 0.23300096037705 no 794 0.253839658889365 1278 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death.
SGTC_1497 4476-2978 41.3 µM 0.659126269560532 0.234121658089654 no 795 0.254907343956637 1268 1528379
SGTC_2306 7482397 179.52 µM 0.65788770029522 0.234539345036828 no 796 0.255305147343408 1283 891448
SGTC_1109 tnp00067 928.257 nM 0.655858641811389 0.235224501255023 no 797 0.255957540480506 1233 676295
SGTC_3333 9141820 12.094 µM 0.655275532918824 0.235421605042595 no 798 0.256145185372504 1253 1939433
SGTC_2267 7931562 200 µM 0.655068350143394 0.235491659373828 no 799 0.256211874218071 1196 934880
SGTC_2007 4011539 71.82 µM 0.654710318548162 0.235612747048774 no 800 0.25632714023883 1287 45595301
SGTC_2135 5326629 150.42 µM 0.654036717255122 0.23584065468423 no 801 0.256544075177772 1237 5020077
SGTC_1194 1488-0194 225 µM 0.653984076439772 0.235858470403567 no 802 0.2565610323086 1241 1391452
SGTC_2893 9048488 25.97 µM 0.653874871036471 0.235895432166893 no 803 0.256596212392742 1213 6467338
SGTC_870 0573-2213 57.6 µM 0.653585185043518 0.235993495026234 no 804 0.256689545747443 1257 3916321
SGTC_195 4234-0266 16.654 µM 0.653498443336664 0.236022862706646 no 805 0.256717496324102 1259 2303354
SGTC_776 4476-4378 112 µM 0.652917861241351 0.236219479150543 no 806 0.256904616717845 1255 2892008
SGTC_2491 paeonol 100 µM 0.651555535054963 0.236681190318599 no 807 0.257343970080639 1210 11092 Increases levels of cortical cytochrome oxidase.
SGTC_1991 st073000 8.92 µM 0.649537662124869 0.23736598659041 no 808 0.257995455594435 1336 4301969 YIL048W NEO1
SGTC_3235 9132602 49.47 µM 0.648586491340233 0.237689157938239 no 809 0.258302844668046 1296 4912240
SGTC_1061 3448-9325 110 µM 0.647919669407048 0.237915862308299 no 810 0.258518454075406 1237 723482
SGTC_2253 7938677 135.83 µM 0.647910168443371 0.237919093277395 no 811 0.258521526779017 1341 2301972
SGTC_209 4077-0173 175.592 µM 0.647719629615937 0.237983894421568 no 812 0.258583152873129 1220 15993494
SGTC_1732 st034308 51.822 µM 0.647196452136516 0.238161873777927 no 813 0.258752403608747 1230 830119
SGTC_821 1114-0266 29.2 µM 0.64662877740697 0.238355073093342 no 814 0.258936114281408 1273 3123235
SGTC_1257 0669-0121 16 µM 0.645997001026792 0.238570189293297 no 815 0.259140648805751 1304 4307855
SGTC_1620 st003704 16.5 µM 0.645130951079484 0.238865246882719 no 816 0.259421163920281 1258 2834414
SGTC_555 4296-0685 37 µM 0.640649967116688 0.240395072076422 no 817 0.260875063863081 1256 2908540 YHR072W ERG7
SGTC_2260 7964312 200 µM 0.640627749282597 0.240402670603972 no 818 0.260882283088737 1316 231951
SGTC_2261 9010538 184.68 µM 0.639866273810054 0.240663175246673 no 819 0.261129770891013 1214 6457250
SGTC_1433 4060-0023 7.6 µM 0.63976037947194 0.240699414405551 no 820 0.261164197256409 1305 3840627
SGTC_1853 st056710 91.2 µM 0.639700579727587 0.240719880385297 no 821 0.261183639249312 1397 269167
SGTC_2833 9001315 45.46 µM 0.639379847313809 0.240829664624419 no 822 0.261287927926436 1312 2989378
SGTC_1023 4482-3888 16 µM 0.639316562413683 0.240851329776504 no 823 0.261308508038162 1299 3303168
SGTC_1493 4348-0038 111 µM 0.639120665132298 0.24091840058972 no 824 0.26137221868539 1327 800424
SGTC_1391 3442-0225 151 µM 0.635791854561149 0.242059661908243 no 825 0.262456048621757 1268 5227075
SGTC_1941 st076221 61.8 µM 0.635517812412906 0.242153745934545 no 826 0.262545376609515 1274 2828568
SGTC_2349 9023730 187.07 µM 0.634953908055078 0.242347407678838 no 827 0.262729238304747 1320 4126287
SGTC_1062 mesoridazine 14.2 µM 0.631437359223663 0.243556987821181 no 828 0.263877297506378 1303 4078 A neuroleptic.
SGTC_180 1486-1293 102.781 µM 0.630602773772592 0.243844536492484 no 829 0.264150142384847 1354 4140536
SGTC_1435 4092-0789 56.7 µM 0.62892933943344 0.244421654322507 no 830 0.264697658577899 1342 2248285
SGTC_3267 9137951 49.47 µM 0.627676198848202 0.244854306776244 no 831 0.265108040149711 1328 16643986
SGTC_2073 5212005 126 µM 0.62690074743781 0.245122241186977 no 832 0.26536214865504 1204 691789
SGTC_591 4299-0174 154 µM 0.625569534868568 0.245582569957324 no 833 0.265798663205001 1292 5509088
SGTC_228 caffeine 993.056 µM 0.625417972771923 0.245635009040945 no 834 0.265848384617137 1307 2519 Caffeine is a phosphodiesterase inhibitor.
SGTC_1555 citronellol 128 µM 0.623735005883458 0.246217703938912 no 835 0.266400814777704 1293 8842 A terpine precursor.
SGTC_3003 9075612 71.4286 µM 0.62367663790566 0.246237926017883 no 836 0.266419984353047 1307 6501993
SGTC_2823 7987624 58.44 µM 0.623616741817346 0.246258678449404 no 837 0.266439656525459 1334 2239440
SGTC_1743 st037606 46.3785 µM 0.623300807337978 0.246368157017726 no 838 0.266543433683672 1335 590142 YLR208W | YDL195W SEC13 | SEC31
SGTC_1881 5652484 16 µM 0.622956788325644 0.246487397184944 no 839 0.266656459204212 1282 2255129
SGTC_1168 k815-0004 80.5 µM 0.622937961897655 0.246493923491072 no 840 0.266662645220934 1279 642433
SGTC_883 0850-0245 24.6 µM 0.622730630874434 0.246565802289229 no 841 0.266730775166602 1376 6823229 YPR165W RHO1
SGTC_980 1473-0395 201 µM 0.622489042934173 0.246649571649045 no 842 0.26681017319284 1248 768876
SGTC_983 1491-0821 12.2 µM 0.622300723707204 0.246714880930192 no 843 0.266872072705653 1287 46495113
SGTC_1560 lithocholic acid 53.1 µM 0.620593991380118 0.247307199293696 no 844 0.267433397045708 1267 9903 A bile acid which acts as a detergent.
SGTC_1886 st057356 49.9 µM 0.620390988548378 0.247377701613898 no 845 0.267500201912168 1251 24207747
SGTC_3226 9131256 49.47 µM 0.620362426289067 0.247387622069321 no 846 0.267509601953432 1217 17178073
SGTC_2774 tamoxifen 10.92 µM 0.619672320802971 0.247627379238937 no 847 0.267736771160897 1329 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.
SGTC_2031 5180455 200 µM 0.619646446618349 0.2476363708885 no 848 0.267745290325884 1273 29949
SGTC_1570 verbenone 133 µM 0.617402228141943 0.248416932037815 no 849 0.268484726361356 1337 29025 A natural terpanoid with antifungal properties.
SGTC_433 pimozide 108 µM 0.616378040813088 0.248773589698242 no 850 0.26882252144422 1259 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic
SGTC_1046 2001-0062 216 µM 0.615971213749873 0.248915336657532 no 851 0.268956759406901 1287 739778
SGTC_521 r062-0005 13.8 µM 0.613927109245884 0.24962819503601 no 852 0.269631747600755 1277 2832033
SGTC_383 2324-0395 7.37 µM 0.613715638142343 0.249702005044498 no 853 0.269701626343194 1348 3146421
SGTC_1804 st050076 49.1 µM 0.611406005340216 0.250508892888718 no 854 0.270465413972587 1338 3895976
SGTC_1304 1165-0502 251 µM 0.611329909034805 0.250535501203519 no 855 0.270490597139499 1338 767425
SGTC_3349 9149703 23.001 µM 0.610459679503078 0.250839897608985 no 856 0.270778672532926 1300 4910494
SGTC_1142 3253-1408 9.78 µM 0.607282586514107 0.251952868753203 no 857 0.271831696294101 1325 256655
SGTC_200 k038-0079 37.545 µM 0.606882157828061 0.252093328091025 no 858 0.271964559842225 1335 3436683
SGTC_2945 9067681 61.76 µM 0.605407314235725 0.252611018583956 no 859 0.272454196162988 1395 16456930
SGTC_3350 9150499 3.57 µM 0.604597735208347 0.252895429903579 no 860 0.2727231559332 1290 4910996 YPR165W RHO1
SGTC_1712 st032288 53.4 µM 0.604445700150692 0.25294885977632 no 861 0.272773679977581 1306 2883011
SGTC_2388 9080168 200 µM 0.603926333660432 0.253131426198609 no 862 0.272946310028199 1279 15943073
SGTC_2328 6201408 200 µM 0.603776547019183 0.253184091701454 no 863 0.272996107044821 1308 2890418
SGTC_1783 st039459 87.517 µM 0.602728895598632 0.253552610620669 no 864 0.27334452776319 1428 729761
SGTC_2974 9094440 9.66 µM 0.601329813269295 0.254045186982048 no 865 0.27381016811766 1446 25236134
SGTC_3149 9097855 49.47 µM 0.601271968766206 0.254065563157661 no 866 0.273829428273833 1381 25236625 YMR079W SEC14
SGTC_990 3985-0011 41.3 µM 0.598635145178668 0.254995314293229 no 867 0.274708107087575 1344 5399565 YGL099W LSG1
SGTC_1717 st033143 58.0435 µM 0.598009905485747 0.255216036311158 no 868 0.274916661842241 1406 674616
SGTC_3326 9140064 16.379 µM 0.596312209611505 0.2558158601459 no 869 0.2754833379873 1313 1868434
SGTC_2645 abamectin 100 µM 0.593883760271654 0.25667514857708 no 870 0.276294930760192 1321 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels.
SGTC_2075 5212009 200 µM 0.593307165608033 0.256879392795062 no 871 0.276487802074498 1338 780898
SGTC_384 k007-0144 5.16 µM 0.592623039453608 0.257121837008583 no 872 0.276716728344041 1375 6824886
SGTC_1796 st049173 110.4 µM 0.592401614545364 0.257200332209602 no 873 0.27679084272244 1310 94134
SGTC_1249 0481-0015 10.2 µM 0.591355424198642 0.257571375446802 no 874 0.277141150436138 1308 4227577
SGTC_1265 0819-1001 68.8 µM 0.591242466195739 0.257611453901272 no 875 0.277178986409982 1320 3106768
SGTC_2048 5246248 200 µM 0.590384522285678 0.257915965326515 no 876 0.277466442431185 1344 677046
SGTC_772 k072-0172 35.3 µM 0.589497357937875 0.258231044295614 no 877 0.277763841986612 1271 5861980
SGTC_2036 5160441 105 µM 0.588065903236779 0.258739849907736 no 878 0.278244029166713 1390 134534 YIL048W NEO1
SGTC_1872 amphotericin b 148 nM 0.587103958960885 0.259082060946791 no 879 0.278566944427935 1350 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1
SGTC_229 benomyl 22.8748 µM 0.585741048510728 0.259567315816009 no 880 0.279024772382535 1345 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C
SGTC_2660 2',4'-dihydroxychalcone 17.14 µM 0.584016411021707 0.260182033053664 no 881 0.279604635445356 1376 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_1602 st001878 87.6 µM 0.583764536515456 0.260271872121786 no 882 0.279689370416151 1389 595405 YLR310C CDC25
SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM 0.581330855954882 0.261140744457276 no 883 0.280508744239909 1361 442882
SGTC_291 SEC14.278 35.5 µM 0.581308417336331 0.261148762420406 no 884 0.280516304296862 1399 1068044
SGTC_220 paclitaxel 373.376 µM 0.580728276046581 0.26135610748686 no 885 0.280711800698791 1383 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_806 3966-4455 5.86 µM 0.580685587427399 0.261371367927663 no 886 0.280726188540893 1299 714982
SGTC_1346 1488-2224 62.4 µM 0.576866480737735 0.262738481842066 no 887 0.282014827715577 1381 3722427
SGTC_1146 3579-1023 7 µM 0.576644740263307 0.262817969807136 no 888 0.282089734585847 1476 X1146
SGTC_258 haloperidol 50.781 µM 0.574340632587044 0.263644657333604 no 889 0.282868659113852 1320 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_3211 9128781 49.47 µM 0.574239598118529 0.263680937684155 no 890 0.282902838360245 1368 17194361
SGTC_1993 st073995 70.8 µM 0.574207155047184 0.263692588169316 no 891 0.282913814042551 1404 3098394
SGTC_712 r015-0009 80.6 µM 0.573942368650224 0.26378768423485 no 892 0.28300340048535 1393 6813872 YLR060W FRS1
SGTC_3288 9119690 36.221 µM 0.572841967658811 0.264183072336453 no 893 0.283375850214603 1334 17595618 YKL019W RAM2
SGTC_322 k048-0136 19.3 µM 0.570567680595016 0.265001208200005 no 894 0.284146365908087 1372 6823282
SGTC_372 0155-0182 15.9 µM 0.570336509740352 0.26508443997754 no 895 0.284224741357774 1379 771486
SGTC_896 0964-0007 44.5 µM 0.569987284000741 0.265210201935675 no 896 0.284343161366468 1364 6756758
SGTC_174 3553-0389 74.3 µM 0.569864052890199 0.265254586724651 no 897 0.284384953802728 1395 738071
SGTC_624 k048-0052 28 µM 0.566491471239661 0.266470769109865 no 898 0.285529864546239 1365 6835531
SGTC_1333 1482-0047 286 µM 0.566446177556657 0.266487121581837 no 899 0.285545255587087 1355 3811116
SGTC_75 0159-0059 199.013 µM 0.565668301580566 0.266768038944035 no 900 0.285809643699971 1500 5377270
SGTC_1813 st051246 8.6015 µM 0.564514649241429 0.267184937265809 no 901 0.286201966659533 1379 5291959
SGTC_769 0302-0231 76 µM 0.564414997564062 0.267220964073278 no 902 0.286235867237967 1402 571869 YER009W NTF2
SGTC_1372 2752-0194 270 µM 0.563919766291763 0.267400040085071 no 903 0.286404368613411 1344 823334
SGTC_2608 thymoquinone 42.66 µM 0.563042015654371 0.26771758405025 no 904 0.286703136994752 1307 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC).
SGTC_1410 3909-8106 77.9 µM 0.562952974089322 0.267749807242099 no 905 0.286733453177702 1426 1039210
SGTC_757 1066-0008 322 µM 0.561554727013131 0.268256074095393 no 906 0.287209716718189 1449 6842497
SGTC_743 1275-0778 158 µM 0.560965526924044 0.268469551394909 no 907 0.287410519015314 1456 2849257 YMR203W TOM40
SGTC_95 0471-0001 561.058 µM 0.560867699132644 0.268505004348216 no 908 0.287443865636232 1300 4015405
SGTC_2948 9070189 9.45 µM 0.560209791692903 0.268743492213645 no 909 0.287668174478916 1377 6473636 YDL196W YDL196W
SGTC_1670 st016595 4.04 µM 0.559486581610831 0.269005774652823 no 910 0.287914843194936 1384 597879
SGTC_1539 benzyladenosine 56 µM 0.558816189692814 0.269249016532544 no 911 0.288143586128354 1362 92208 A nucleotide analog.
SGTC_1387 3342-1166 1.8 µM 0.558456615128388 0.269379528330831 no 912 0.288266311083587 1394 3418228
SGTC_448 monastrol 171 µM 0.558369737362863 0.269411066389896 no 913 0.288295966683227 1399 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity
SGTC_2414 st077232 92.9 µM 0.558251673726955 0.269453928400106 no 914 0.288336269840531 1352 729801
SGTC_2373 9071805 200 µM 0.558077440882094 0.269517188412923 no 915 0.288395752225805 1443 10149009
SGTC_2982 9019404 25.97 µM 0.557277293095477 0.269807799556201 no 916 0.288668993684802 1243 22333232
SGTC_3315 9136395 68.55 µM 0.556570313884317 0.270064702662219 no 917 0.288910520536037 1423 16876844
SGTC_592 k241-0073 46.5 µM 0.556076740031278 0.270244130745112 no 918 0.289079197600492 1475 4230158
SGTC_303 1348-1668 34.2 µM 0.555694397379265 0.270383164095202 no 919 0.289209893635186 1413 5380509
SGTC_1788 fluconazole 20 µM 0.555464489233901 0.270466784060875 no 920 0.289288496415168 1394 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11
SGTC_1949 st076024 69.1 µM 0.554814674649534 0.270703198188927 no 921 0.289510714340115 1379 2921930
SGTC_2287 7945887 168.79 µM 0.554289281411347 0.270894421025254 no 922 0.289690442325933 1435 1245853
SGTC_1024 4507-0395 26 µM 0.55378133169043 0.271079359161632 no 923 0.289864252954853 1435 4201836
SGTC_866 0495-0101 262 µM 0.552478035741236 0.271554160779313 no 924 0.290310439387273 1353 635694
SGTC_828 2074-0507 139 µM 0.551714100962785 0.271832661009139 no 925 0.290572123691766 1489 X828
SGTC_2425 5628681 7.85 µM 0.550979423119836 0.272100629316917 no 926 0.29082389015367 1443 5714958
SGTC_1482 3346-2049 8.48 µM 0.550163600963585 0.272398348220627 no 927 0.291103583367606 1418 3826804
SGTC_1588 farnesol 29.9 µM 0.549294291339165 0.272715764324868 no 928 0.291401752191488 1404 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM 0.548917241017173 0.272853495956626 no 929 0.291531122842755 1633 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W
SGTC_761 k216-0224 480 µM 0.548713270936981 0.272928017980227 no 930 0.29160111867426 1532 1340404
SGTC_1621 st003705 32.4 µM 0.545620363566452 0.274059270578751 no 931 0.292663461805518 1493 24207032
SGTC_3217 9129673 49.47 µM 0.544485812585449 0.274474820619015 no 932 0.293053604374913 1409 17248312
SGTC_51 1013-0126 23.419 µM 0.543803496407829 0.274724881030897 no 933 0.293288351273066 1532 1627850
SGTC_2493 resveratrol 26.09 µM 0.542511513209149 0.275198684357691 no 934 0.293733089146608 1376 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase.
SGTC_600 1495-0418 41.6 µM 0.541882417410795 0.275429535449638 no 935 0.293949754979991 1428 5377768
SGTC_3336 9143619 71.43 µM 0.539923753005668 0.276148890515349 no 936 0.294624808093133 1440 45595730
SGTC_470 aa-861 153 µM 0.537788833959454 0.276934027254955 no 937 0.295361420823889 1391 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor.
SGTC_1801 st050089 28.441 µM 0.537540651624585 0.277025369528899 no 938 0.295447106311721 1428 5008493 YIL048W | YNL267W NEO1 | PIK1
SGTC_3239 9133757 49.47 µM 0.5369163757414 0.277255196342827 no 939 0.295662689445864 1482 17036923
SGTC_2652 actinonin 100 µM 0.535336259133093 0.277837331810497 no 940 0.296208678869302 1418 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase.
SGTC_359 0081-0058 15.9 µM 0.535125816147797 0.277914906743011 no 941 0.296281429683403 1588 3494159
SGTC_2244 6635614 200 µM 0.534724348317522 0.27806292787556 no 942 0.29642024112078 1434 836499
SGTC_1854 st056233 32.9 µM 0.533823401089584 0.278395246929764 no 943 0.296731860916542 1443 5393174
SGTC_956 1185-0240 191 µM 0.533760173033657 0.278418576192136 no 944 0.296753735879879 1446 1416193
SGTC_3168 9103419 49.47 µM 0.533480493329494 0.278521781066855 no 945 0.296850505312836 1410 16649256
SGTC_1423 4048-0112 5.59 µM 0.532734511206251 0.278797147752144 no 946 0.297108686414251 1493 X1423
SGTC_3 0833-0587 95.581 µM 0.531220124112269 0.279356565326452 no 947 0.297633124587136 1373 5382644
SGTC_1196 1588-0294 184 µM 0.530816234834982 0.279505854882107 no 948 0.297773064352514 1398 6144269
SGTC_549 1661-1316 519 µM 0.529668701374959 0.279930228843264 no 949 0.298170826015994 1517 2857282
SGTC_2766 oltipraz 83.91 µM 0.528853061573293 0.28023205371596 no 950 0.298453692711059 1509 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40
SGTC_193 1273-0060 1.558 µM 0.528581400440241 0.280332616027059 no 951 0.298547932828362 1366 2847393 YHR072W ERG7
SGTC_1652 st011932 78 µM 0.526776047641667 0.281001357116976 no 952 0.299174559071123 1486 1551076
SGTC_103 0844-0104 51.839 µM 0.524782795463255 0.281740594365468 no 953 0.299867096434699 1475 5375804
SGTC_1202 1988-0068 29.6 µM 0.523521240373231 0.282208951099169 no 954 0.300305786949653 1388 2850480
SGTC_1882 5615643 20 µM 0.522923913102188 0.282430841580543 no 955 0.300513601413207 1390 2253075
SGTC_2629 bisabolol 100 µM 0.521311595271459 0.283030191412805 no 956 0.301074862382064 1504 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer.
SGTC_1437 4092-1038 11.6 µM 0.519954963308421 0.283534967163736 no 957 0.301547482680558 1411 3977136
SGTC_2895 9054447 58.44 µM 0.519853109432069 0.283572882367287 no 958 0.301582979764986 1464 2697450
SGTC_230 MPP+ 141.667 µM 0.519773296166067 0.283602594629953 no 959 0.301610796791979 1399 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death.
SGTC_2905 7799065 20.05 µM 0.519078639069975 0.28386125913971 no 960 0.301852951817186 1499 1296806
SGTC_1251 0490-5699 265 µM 0.518800438573337 0.28396488233527 no 961 0.301949956029806 1527 3883818
SGTC_1571 st070080 73.4 µM 0.518702075597557 0.28400152458017 no 962 0.301984257029659 1552 4315245
SGTC_3106 9121286 49.47 µM 0.516289789539043 0.284900858367828 no 963 0.302826013224947 1493 15943471
SGTC_2064 5220758 200 µM 0.516137239220677 0.284957776888573 no 964 0.302879280265724 1482 788518
SGTC_1286 0929-0070 131 µM 0.515312153789436 0.285265721017438 no 965 0.303167453670446 1511 1420408
SGTC_1775 st081588 35.1725 µM 0.515294055901865 0.285272477413671 no 966 0.303173776001922 1454 1426443 YGL099W LSG1
SGTC_2080 5212524 12.4 µM 0.512268429899215 0.286403089999546 no 967 0.304231578473706 1525 260183
SGTC_1266 0828-0227 32.9 µM 0.511812433056033 0.28657367063716 no 968 0.304391143997494 1506 3913820
SGTC_1628 st004252 77.7 µM 0.510289257066633 0.287143813852353 no 969 0.304924413971042 1568 692968
SGTC_1553 gossypol 38.6 µM 0.508809657215424 0.287698159652558 no 970 0.305442824800005 1425 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_746 1095-0025 46.6 µM 0.508760542764545 0.287716569505544 no 971 0.305460039843691 1551 6749286
SGTC_2273 7815444 169.05 µM 0.507808999826765 0.288073351646181 no 972 0.305793648809677 1576 2824616
SGTC_3266 9136860 49.47 µM 0.506383880176341 0.288608092122434 no 973 0.306293594292732 1415 4871271 YPR165W RHO1
SGTC_3178 9107506 49.47 µM 0.5062863918161 0.288644689270422 no 974 0.306327807331443 1486 8897194
SGTC_3075 9116269 49.47 µM 0.506207658912425 0.288674247212054 no 975 0.306355439471753 1510 17015205 YNL244C SUI1
SGTC_2761 levamisole 97.89 µM 0.506100802843758 0.288714365444871 no 976 0.306392943494108 1565 26879 An alkaline phosphatase inhibitor.
SGTC_1613 st002381 52.1 µM 0.505682364789223 0.28887148983859 no 977 0.306539825146274 1454 551167
SGTC_3190 9110366 49.47 µM 0.503667362230596 0.289628690616356 no 978 0.30724757359061 1539 17123768
SGTC_2715 st079500 56.4 µM 0.502823050753887 0.289946244045783 no 979 0.307544342885015 1423 28246688
SGTC_2872 9044037 25.97 µM 0.502297823166688 0.290143869379915 no 980 0.307729020120792 1546 6465195
SGTC_2854 9024559 71.43 µM 0.500171424945795 0.290944605285134 no 981 0.308477188533145 1444 3163529
SGTC_2421 5690543 90.72 µM 0.498248130020007 0.291669746964045 no 982 0.309154581292523 1517 3397993
SGTC_2239 6685329 187.64 µM 0.49721501921174 0.292059609174395 no 983 0.309518715610474 1480 805680
SGTC_1887 st057648 70.8 µM 0.496601858112912 0.292291110756091 no 984 0.309734921287303 1586 688672
SGTC_2030 5175110 200 µM 0.496545706598355 0.292312315264498 no 985 0.309754724067865 1549 2831986
SGTC_3141 9094609 49.47 µM 0.496311456765089 0.2924007827958 no 986 0.309837342186141 1431 25236309 YDL196W YDL196W
SGTC_2788 5282734 71.43 µM 0.496214091310601 0.292437557802653 no 987 0.309871685060917 1623 743706
SGTC_1933 st074711 15.9 µM 0.496172651272447 0.292453210389134 no 988 0.309886302350624 1447 17250958
SGTC_1211 1056-0033 32.3 µM 0.494916164350854 0.292927991052591 no 989 0.310329650005137 1504 6741922
SGTC_805 3852-0218 479 µM 0.494861719808249 0.292948571746223 no 990 0.310348866836931 1438 6615355
SGTC_2133 5320837 200 µM 0.494853949161665 0.292951509199053 no 991 0.310351609618852 1541 2841355
SGTC_92 0063-0024 660.874 µM 0.494813778505954 0.292966694692138 no 992 0.310365788703433 1491 3594437
SGTC_1762 st045503 25.4615 µM 0.494756640406777 0.292988294924226 no 993 0.310385957292453 1490 4645554
SGTC_1193 1488-0126 41.5 µM 0.494118490760257 0.293229588365227 no 994 0.310611249894832 1486 1384710
SGTC_1585 2',4'-dihydroxychalcone 10.4 µM 0.493838575346954 0.293335457415818 no 995 0.310710093764476 1521 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_2114 5491910 81.25 µM 0.493128055986553 0.293604268148746 no 996 0.310961054063552 1577 2849228
SGTC_689 0833-0039 98 µM 0.492205659234696 0.293953408470147 no 997 0.311286982087385 1545 5374726
SGTC_3012 9080433 71.4286 µM 0.490985446462978 0.294415571139182 no 998 0.311718370490461 1571 17688859
SGTC_1594 piperine 70.1 µM 0.49057151281151 0.294572427075732 no 999 0.311864769436479 1454 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_2663 amphotericin b 100 µM 0.490533963490481 0.294586657915376 no 1000 0.311878051250976 1492 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM 0.490379050825342 0.294645371712412 no 1001 0.311932849003498 1476 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_2294 7971431 200 µM 0.489365102205553 0.295029803878166 no 1002 0.312291619041514 1502 5741572
SGTC_1349 flufenamic acid 69 µM 0.48911366280998 0.29512517126507 no 1003 0.312380614546859 1461 3371 A non-steroidal anti-inflammatory.
SGTC_2205 7238770 200 µM 0.48837995059518 0.295403538990709 no 1004 0.312640370254412 1531 279867
SGTC_3014 9081533 49.47 µM 0.487415000240582 0.295769821393765 no 1005 0.312982132777173 1600 21367265
SGTC_468 gf-109203x 121 µM 0.487370200300452 0.295786831926562 no 1006 0.312998003760538 1498 2396 A protein kinase C inhibitor.
SGTC_3061 glucosamine 200 µM 0.486297311503148 0.296194341892533 no 1007 0.313378192562779 1522 91431 and experimental redox chemotherapeutic
SGTC_325 2810-4341 181 µM 0.486183243066882 0.296237683076853 no 1008 0.313418625520969 1602 774970
SGTC_522 1273-0010 11.6 µM 0.485605115413108 0.296457391867099 no 1009 0.313623584442854 1538 5705015
SGTC_868 0527-0199 213 µM 0.484865569203802 0.29673855418925 no 1010 0.313885853666697 1522 2849450
SGTC_1503 4585-0012 61.3 µM 0.483816840034156 0.297137471557146 no 1011 0.314257931337879 1568 2922052
SGTC_2044 5102272 200 µM 0.481546565218146 0.298001881283238 no 1012 0.315064046534803 1497 592666
SGTC_2374 9071832 200 µM 0.48139217136435 0.29806070851909 no 1013 0.315118899811245 1475 17381698
SGTC_2121 5257820 149.641 µM 0.481293008174115 0.298098494525995 no 1014 0.315154132806239 1566 791256
SGTC_128 0906-2981 13.371 µM 0.480301308698086 0.298476500334469 no 1015 0.315506579220828 1569 6740226
SGTC_909 3448-9333 149 µM 0.479167585019735 0.298908908441192 no 1016 0.315909706217501 1473 3344074
SGTC_766 1391-0721 126 µM 0.478995895920355 0.298974416359708 no 1017 0.315970774161983 1620 1020919 YIL115C NUP159
SGTC_1814 st052110 31.539 µM 0.478388264668545 0.299206310215624 no 1018 0.316186942318091 1581 674163
SGTC_2712 st079126 47.7 µM 0.478381953735416 0.299208719122018 no 1019 0.316189187797081 1471 3152970
SGTC_2097 5376186 200 µM 0.477230813654506 0.299648260646786 no 1020 0.316598885697153 1569 742755
SGTC_888 0916-0002 6.97 µM 0.477155582487621 0.299676996455909 no 1021 0.316625668778384 1557 2802138 YIL048W NEO1
SGTC_618 k072-0232 33.2 µM 0.474718780190411 0.300608448306756 no 1022 0.317493715118085 1525 5872756 YGL099W LSG1
SGTC_12 0849-0099 9.267 µM 0.47418789780821 0.300811547915913 no 1023 0.317682961347164 1563 6071388
SGTC_2182 6325192 200 µM 0.474071508951217 0.300856083059028 no 1024 0.317724457419447 1486 736248
SGTC_185 k048-0037 25.491 µM 0.47340121877304 0.301112621392269 no 1025 0.317963480256869 1570 6827589
SGTC_1027 k015-0025 8.67 µM 0.472382216751469 0.301502809972758 no 1026 0.3183269976562 1477 3598955
SGTC_3045 9092950 49.47 µM 0.471081586303293 0.302001167830069 no 1027 0.318791237027008 1638 44120432
SGTC_2740 felodipine 17.08 µM 0.471063848731627 0.302007966827766 no 1028 0.318797570139354 1607 3333 L-type calcium channel blocker
SGTC_1449 4112-4002 201 µM 0.471019194529182 0.302025083557402 no 1029 0.318813513936051 1456 2059539
SGTC_1640 st009078 66.4 µM 0.470145630235212 0.302360023480933 no 1030 0.319125487754945 1596 690618
SGTC_3063 1327-0034 4 µM 0.469336231922996 0.302670509654568 no 1031 0.319414660522634 1478 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_1214 0358-0031 63.7 µM 0.467778447657177 0.303268479229209 no 1032 0.319971517339569 1708 4301366
SGTC_651 3253-0966 34.4 µM 0.463267896181941 0.30500286575176 no 1033 0.321586177189669 1510 781462
SGTC_2918 7977171 22.06 µM 0.462848615752732 0.305164310023779 no 1034 0.321736440621356 1510 2236483
SGTC_1525 8-methoxypsoralen 92.5 µM 0.462403141678072 0.30533588172674 no 1035 0.3218961233914 1711 4114 Related to psoralen; DNA damaging agent.
SGTC_222 nsc-310342 10.666 µM 0.461890266130613 0.305533465678573 no 1036 0.322080007348074 1610 432556
SGTC_1874 staurosporine 7.6 µM 0.460047372113534 0.306243902915359 no 1037 0.32274110904398 1607 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1
SGTC_255 tunicamycin 200.472 nM 0.458988282042725 0.3066525131808 no 1038 0.323121290444236 1596 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_1630 st005209 31.3 µM 0.456882617527622 0.307465618882372 no 1039 0.323877709298768 1586 3367314
SGTC_2795 7780010 54.55 µM 0.453942876635363 0.308602388113321 no 1040 0.32493497097563 1553 953673
SGTC_899 1083-0020 478 µM 0.453938943703274 0.308603910172619 no 1041 0.32493638638036 1632 767123
SGTC_214 4373-3496 70 µM 0.453885139361428 0.308624732982584 no 1042 0.324955750029706 1608 3779166
SGTC_126 0417-1624 672.48 µM 0.453174446837338 0.30889983571621 no 1043 0.325211565584102 1594 41912 YDL195W SEC31
SGTC_2106 5357045 167.29 µM 0.451019440273633 0.309734674654976 no 1044 0.325987768936563 1624 668842
SGTC_1768 st044301 37.178 µM 0.450621652502688 0.309888883210411 no 1045 0.326131129159348 1515 3931349
SGTC_102 gallobenzophenone 83.616 µM 0.450610991052372 0.309893016746283 no 1046 0.326134971833022 1630 70837
SGTC_169 k015-0017 16.025 µM 0.449976629234742 0.310139007514332 no 1047 0.326363646123235 1645 1840002
SGTC_2878 9043973 25.97 µM 0.449951986851868 0.310148564973179 no 1048 0.326372530509369 1633 6465167
SGTC_1799 st045822 46.1415 µM 0.447597865155073 0.311062193119857 no 1049 0.327221722076695 1642 3674992
SGTC_1279 0874-0590 65.2 µM 0.446812911298973 0.311367090952827 no 1050 0.327505074107763 1574 3523074
SGTC_2015 5119600 184 µM 0.444917829399696 0.312103726456248 no 1051 0.328189568681846 1673 2828786
SGTC_2851 9015922 71.43 µM 0.442573187248384 0.313016150680288 no 1052 0.329037241143628 1640 2996893
SGTC_2481 5478948 45.16 µM 0.440592242146393 0.313787934943767 no 1053 0.329754110074857 1545 77792
SGTC_1626 st003712 1.76 µM 0.439933644826427 0.314044707946742 no 1054 0.329992583534345 1607 24207035
SGTC_1974 st069448 26.9 µM 0.438343382483032 0.314665088267019 no 1055 0.330568691072875 1663 6323587 YNR016C ACC1
SGTC_441 propafenone 146 µM 0.438208825254614 0.314717604694887 no 1056 0.33061745584128 1540 4932 Slows the influx of sodium ions into the cardiac muscle.
SGTC_1354 1498-1681 81 µM 0.438159564459132 0.314736831659921 no 1057 0.330635309122508 1596 5754243
SGTC_1643 st009866 20.2 µM 0.437974991016952 0.314808876926295 no 1058 0.330702206344441 1629 3156273 YOR207C RET1
SGTC_2666 tannic acid 100 µM 0.437830350258902 0.314865340040011 no 1059 0.330754634052388 1599 16134267 A thiamine antagonist.
SGTC_734 2023-0417 80 µM 0.437133081996851 0.315137591908804 no 1060 0.331007418348908 1608 3935732
SGTC_844 0330-0132 15.3 µM 0.436973851193711 0.315199778463018 no 1061 0.331065155933528 1631 2828079
SGTC_2355 9061122 103.12 µM 0.436003025552126 0.315579041351032 no 1062 0.331417267206814 1673 5302957
SGTC_1554 st069299 38.7 µM 0.434003988380582 0.316360597231134 no 1063 0.332142772403831 1600 24207999
SGTC_838 0109-0203 71.4 µM 0.43045074988145 0.317751818212052 no 1064 0.333433892625732 1585 759422
SGTC_2270 7924575 90.91 µM 0.429740063399636 0.318030387474016 no 1065 0.333692368355013 1718 1262135
SGTC_2005 4024620 188 µM 0.428993882805823 0.318322980269951 no 1066 0.333963838210268 1559 236743
SGTC_1299 1079-1439 3.74 µM 0.427945836810698 0.318734132142727 no 1067 0.334345277221199 1533 323161
SGTC_3110 9122132 49.47 µM 0.426665889917169 0.319236562269822 no 1068 0.334811349220527 1664 918317
SGTC_1216 1165-0504 9.65 µM 0.426160294278768 0.319435120266122 no 1069 0.334995523892543 1681 6304004
SGTC_2280 7785178 200 µM 0.423923654001024 0.320314116381247 no 1070 0.335810746406326 1602 2954328
SGTC_846 0335-0850 148 µM 0.421070709917354 0.321436783197631 no 1071 0.336851724480064 1603 6819598
SGTC_1763 st044482 94.5 µM 0.420489736780153 0.321665603394096 no 1072 0.337063862686066 1649 88505
SGTC_2624 nerol 100 µM 0.420464540683332 0.321675528578641 no 1073 0.337073064034563 1683 637566 A natural product oil.
SGTC_1436 4092-1007 8.32 µM 0.419636838397557 0.322001645755698 no 1074 0.337375386339714 1586 2881121
SGTC_2060 5238662 140 µM 0.417607119378354 0.322801941139131 no 1075 0.338117195336193 1580 790130
SGTC_2259 7964009 200 µM 0.416329842996306 0.323305978184876 no 1076 0.338584328944933 1647 313134
SGTC_1365 1672-3266 55.4 µM 0.414721423473644 0.32394115202373 no 1077 0.339172923693918 1681 6415873
SGTC_355 1311-2252 105 µM 0.413536141222376 0.32440955502633 no 1078 0.339606924462943 1571 5338538
SGTC_190 3970-0790 3.722 µM 0.411801831667554 0.325095424876572 no 1079 0.340242339367603 1668 2832352
SGTC_365 0121-0052 13.6 µM 0.40959829277094 0.325967716874606 no 1080 0.341050324747665 1644 3101739
SGTC_2894 9048625 32.47 µM 0.409382532307069 0.326053179040587 no 1081 0.341129478254771 1736 4092861
SGTC_101 0490-5701 117.494 µM 0.408932166012869 0.326231597412892 no 1082 0.341294721372518 1695 4661669
SGTC_1744 st037937 38.9 µM 0.408542900916176 0.326385841814435 no 1083 0.341437570478458 1668 1016152
SGTC_342 k048-0088 23.3 µM 0.407458380225323 0.326815734407092 no 1084 0.341835678179129 1564 6820570
SGTC_2172 5754775 163.918 µM 0.406769106726828 0.327089074746916 no 1085 0.342088789347372 1568 2263357
SGTC_1597 7-benzyloxygramine 47.5 µM 0.405835927620762 0.327459286832129 no 1086 0.342431579246023 1578 260807
SGTC_414 piperonyl butoxide 100 µM 0.404117045506705 0.32814164816401 no 1087 0.343063325496659 1575 5794 A potent inhibitor of cytochrome P450.
SGTC_3093 9117344 49.47 µM 0.403819180118424 0.32825995308736 no 1088 0.34317284558777 1629 24824913
SGTC_1034 k072-0165 12.7 µM 0.401603740018234 0.329140412135466 no 1089 0.343987838477539 1758 5835461
SGTC_1526 st051518 75 µM 0.400630219203614 0.329527608574857 no 1090 0.344346196741672 1615 673993
SGTC_1883 5-benzylidenerhodanine 20 µM 0.400403827037955 0.329617677284652 no 1091 0.344429552964369 1720 1273210
SGTC_681 1642-0006 26.6 µM 0.399777446038912 0.329866930544639 no 1092 0.344660222015686 1583 4446530
SGTC_2722 naftopidil 47.16 µM 0.399706019382121 0.329895357867067 no 1093 0.344686529037279 1671 4418 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_1305 1181-0477 144 µM 0.399155104830734 0.330114651103675 no 1094 0.344889460598868 1729 6252086
SGTC_898 1000-0849 28.3 µM 0.399048954862558 0.330156911136103 no 1095 0.344928566490612 1666 6751807
SGTC_1291 0993-0025 5.79 µM 0.398965786549823 0.330190023310976 no 1096 0.344959207045185 1713 4353356
SGTC_1385 3091-4834 14.1 µM 0.397771356948248 0.330665713548501 no 1097 0.345399366336388 1691 4072814
SGTC_628 1636-0253 16 µM 0.397442013312861 0.33079692519559 no 1098 0.345520769582239 1710 4456143
SGTC_1072 oxiconazole 14.9 nM 0.396655510817675 0.331110354607639 no 1099 0.345810755824207 1643 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_2891 9063876 19.48 µM 0.396156676743164 0.331309206533296 no 1100 0.345994724607447 1717 6472478
SGTC_2314 7727897 200 µM 0.395561004367352 0.331546723761153 no 1101 0.346214454746866 1575 900724
SGTC_2546 rhodinyl acetate 100 µM 0.394249218076109 0.332070021625953 no 1102 0.346698525679646 1756 6708682
SGTC_2896 9052656 71.43 µM 0.394247743945673 0.332070609870661 no 1103 0.346699069799256 1624 6469436
SGTC_804 1595-0054 20.9 µM 0.393442266110331 0.332392093811086 no 1104 0.346996428805946 1634 761523 Stimulates phospholipase C.
SGTC_1185 1319-0113 81.3 µM 0.391571543163825 0.333139216115023 no 1105 0.347687408713429 1696 4672763
SGTC_1240 0356-0016 42.1 µM 0.390330837976895 0.333635090017049 no 1106 0.348145961398173 1675 4305613
SGTC_1622 st003707 19.4 µM 0.389907800011064 0.333804232546833 no 1107 0.348302362965245 1679 10140899
SGTC_778 3456-2434 196 µM 0.389349702129064 0.334027427515835 no 1108 0.348508737064314 1805 5539063
SGTC_2430 5571206 200 µM 0.389144309784551 0.334109582978024 no 1109 0.34858469858271 1783 1731771
SGTC_1564 D-Arginine 115 µM 0.388402064742076 0.334406541909531 no 1110 0.348859258245006 1545 71070 D-isomer of arginine; arginine decarboxylase inhibitor.
SGTC_3081 9117243 49.47 µM 0.388273097945162 0.334458149786651 no 1111 0.34890697169891 1764 45595589
SGTC_1455 4262-0120 131 µM 0.387478276497419 0.334776277786316 no 1112 0.349201082086676 1726 1529587
SGTC_388 3',4'-dichloroisocoumarin 16.7 µM 0.387006735900278 0.3349650684131 no 1113 0.349375610626468 1671 1609 A potent and irreversible inhibitor of serine proteases.
SGTC_2848 9016370 25.97 µM 0.386079733240032 0.335336333871236 no 1114 0.349718809482903 1786 7894410
SGTC_155 k072-0202 43.6 µM 0.385864878851276 0.335422406238828 no 1115 0.349798371331719 1681 5857737
SGTC_2970 9090938 41.86 µM 0.385821618471067 0.335439737734273 no 1116 0.34981439170384 1787 17217104
SGTC_2913 7966556 36.57 µM 0.3838216032291 0.336241389790815 no 1117 0.350555337571262 1756 2976516
SGTC_304 1310-0298 97 µM 0.38176136177026 0.337067961199389 no 1118 0.351319190389451 1651 1550234
SGTC_3218 9131285 49.47 µM 0.38078946100824 0.337458162536071 no 1119 0.351679740037083 1778 17156417
SGTC_1009 4106-0057 9.87 µM 0.380434939097403 0.337600540493507 no 1120 0.351811291587172 1745 2928005
SGTC_807 1315-0151 48 µM 0.37993296253769 0.337802176813192 no 1121 0.351997589106935 1792 4011080
SGTC_1338 1486-1223 76 µM 0.379266212850097 0.338070071967851 no 1122 0.352245093472862 1720 3444526
SGTC_2258 7960471 200 µM 0.378874283692213 0.338227584527797 no 1123 0.352390610839602 1632 2974708
SGTC_1540 guanosine 70.6 µM 0.378700635755371 0.338297381018138 no 1124 0.352455090600749 1734 6802 Guanosine is a purine nucleoside
SGTC_2747 doxorubicin 7.63 µM 0.37753399766477 0.338766446451098 no 1125 0.352888401954046 1723 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_2354 9060492 162 µM 0.376903002954292 0.339020252219836 no 1126 0.353122844847572 1764 6471895
SGTC_692 k241-0027 77.8 µM 0.376454545600865 0.339200680201775 no 1127 0.353289500812952 1735 3600480
SGTC_1302 1159-0335 255 µM 0.375830954335684 0.339451631152393 no 1128 0.353521286897906 1634 649284
SGTC_2763 lisinopril 49.32 µM 0.375665930310481 0.339518053457731 no 1129 0.353582634684395 1701 5362119 A lysine-analog of enalapril and an ACE inhibitor.
SGTC_2723 salbutamol 83.58 µM 0.372414640318962 0.3408277147219 no 1130 0.354792077606333 1740 9884233 β2-adrenoceptor agonist
SGTC_3251 9135047 49.47 µM 0.370115607942296 0.341754954836375 no 1131 0.355648176576079 1773 17682963
SGTC_2739 tacrine 100.86 µM 0.369329122745164 0.342072377766709 no 1132 0.355941210396952 1676 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders.
SGTC_1317 1273-0028 910 nM 0.368740685137289 0.342309942345536 no 1133 0.35616051002873 1663 5917803 YLR359W | YHR072W ADE13 | ERG7
SGTC_1926 methyl fluorone black 53.6 µM 0.368287186196027 0.342493071952071 no 1134 0.356329553031018 1614 72721 Reacts with homocysteine.
SGTC_2022 5136654 200 µM 0.367705993043188 0.342727820516196 no 1135 0.356546235685234 1688 1713771
SGTC_1382 3002-2117 298 µM 0.366517151925024 0.343208192081524 no 1136 0.356989608162769 1795 1497314
SGTC_2541 muurolladie-3-one 83.07 µM 0.36639646969565 0.343256969981623 no 1137 0.357034626822149 1698 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils. YMR203W TOM40
SGTC_3311 9131146 2.8755 µM 0.365725997789031 0.343528011944335 no 1138 0.357284772344982 1663 4900406 YPR165W RHO1
SGTC_191 3914-0123 66.505 µM 0.362279099925947 0.344922707098463 no 1139 0.358571737387148 1640 3144412
SGTC_137 0438-0332 85.389 µM 0.362242289054159 0.344937613052866 no 1140 0.358585490130104 1679 2063393 YER012W | YPR107C PRE1 | YTH1
SGTC_2146 5545642 200 µM 0.361817386800715 0.345109687616491 no 1141 0.358744249206305 1676 825326
SGTC_394 menadione 8.33 µM 0.360192299670408 0.345768101671293 no 1142 0.359351666385061 1744 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_845 0330-0138 4.51 µM 0.359529670346555 0.346036704092254 no 1143 0.359599442910106 1777 9039800
SGTC_1715 st032160 10.2275 µM 0.358462147641223 0.346469596407939 no 1144 0.359998745064149 1768 5289825
SGTC_552 k242-0005 476 µM 0.35730991804198 0.34693706341918 no 1145 0.360429902946164 1687 4088318
SGTC_1021 4476-0760 85.3 µM 0.356567098715758 0.34723855363809 no 1146 0.360707955946597 1634 746768
SGTC_1943 st076331 65.2 µM 0.354879668118228 0.347923795033251 no 1147 0.361339870443272 1740 24208415
SGTC_918 glabranin 770.725 nM 0.354648936342738 0.348017530573927 no 1148 0.361426305081475 1735 124049 Also referred to as licorice root.
SGTC_1514 1189-1591 158 µM 0.354014643595456 0.348275261928367 no 1149 0.361663954495609 1769 767698 YMR146C TIF34
SGTC_2998 9066762 71.4286 µM 0.351575553429587 0.349266986251185 no 1150 0.362578300833267 1803 4945196
SGTC_2864 9034755 47.6 µM 0.351391064483902 0.349342040706288 no 1151 0.36264749252225 1762 4930451
SGTC_2029 5175081 200 µM 0.351375713831437 0.349348285979366 no 1152 0.36265324991257 1674 1380876
SGTC_300 r073-0011 5.04 µM 0.351245266286957 0.349401359020056 no 1153 0.362702176605925 1737 2735780
SGTC_2365 9042475 200 µM 0.349748667812901 0.350010465799952 no 1154 0.363263662948636 1674 6464479
SGTC_1451 4152-0210 104 µM 0.349610355446173 0.350066777635079 no 1155 0.363315569148448 1805 659563
SGTC_1114 scopoletin 1.73284 µM 0.347322258393581 0.350998820128866 no 1156 0.364174615311765 1818 5280460 A coumarin with genotoxic properties.
SGTC_140 0062-0056 502.533 µM 0.346844206262268 0.351193665262966 no 1157 0.364354182215494 1615 3758964
SGTC_3302 9125395 16.351 µM 0.346085418343926 0.35150301338256 no 1158 0.364639260786062 1721 17599668
SGTC_2601 securinine 100 µM 0.345997944090496 0.351538681843806 no 1159 0.364672129903837 1666 442872 A GABA receptor antagonist.
SGTC_2118 5526350 200 µM 0.345794186424563 0.35162177104403 no 1160 0.364748697257761 1748 743594
SGTC_587 k089-0003 57 µM 0.343904623525378 0.352392642573316 no 1161 0.365459007326117 1800 9659696
SGTC_2304 7443016 91.4 µM 0.343451566755555 0.352577563216449 no 1162 0.365629385680838 1691 939854
SGTC_3181 9108277 49.47 µM 0.341571461035823 0.353345323182616 no 1163 0.366336708776198 1673 17097298
SGTC_809 3998-0021 90 µM 0.340968502361236 0.353591674007872 no 1164 0.366563646926463 1828 715485
SGTC_1200 1643-0193 18.4 µM 0.340256605042398 0.353882612848461 no 1165 0.366831646845432 1805 5403974
SGTC_1153 4055-0057 267 µM 0.339519216357953 0.354184059510218 no 1166 0.367109311662238 1692 882706
SGTC_2967 9089538 49.85 µM 0.339513007945902 0.354186597915567 no 1167 0.367111649744451 1904 728216
SGTC_2927 9011802 47.9 µM 0.339312596933119 0.35426854253945 no 1168 0.367187126992598 1645 43912568
SGTC_688 0527-0193 473 µM 0.338296608259987 0.354684066617955 no 1169 0.36756983971242 1759 4007154
SGTC_2875 9039966 71.43 µM 0.337820138896548 0.354878995027651 no 1170 0.367749366270432 1824 6463691
SGTC_1428 4049-0204 61.7 µM 0.336907231263949 0.355252580830757 no 1171 0.368093416964978 1812 X1428
SGTC_1856 st057054 55.7 µM 0.335081680290302 0.356000061353081 no 1172 0.368781735921621 1844 1266018
SGTC_302 1094-0063 18.9 µM 0.335042987511986 0.356015910298675 no 1173 0.368796329492175 1726 5440289
SGTC_1825 st052143 62.6 µM 0.331821324089502 0.357336405998508 no 1174 0.370012090710988 1816 674173
SGTC_320 4092-0846 5.34 µM 0.331083260945312 0.357639164736534 no 1175 0.370290797562402 1793 1359356
SGTC_1331 1472-0049 76.2 µM 0.330148407051196 0.358022777041747 no 1176 0.370643914148139 1689 24051409
SGTC_1674 st016616 23.6 µM 0.329489865304615 0.358293092244391 no 1177 0.370892726507383 1638 625830
SGTC_1103 duloxetine 36.1 µM 0.329456830887078 0.358306653933113 no 1178 0.370905209100172 1828 60835 A selective serotonin reuptake inhibitor.
SGTC_1822 st052468 42 µM 0.328887414381429 0.358540445766499 no 1179 0.371120393745235 1721 2873678
SGTC_2207 7258803 200 µM 0.32887132386509 0.358547053004204 no 1180 0.371126474997857 1799 3666799
SGTC_3105 9121040 49.47 µM 0.327229452686069 0.359221475715643 no 1181 0.371747173010224 1825 41448907
SGTC_3185 9108267 49.47 µM 0.32658377496156 0.359486817687132 no 1182 0.371991358462041 1680 4910486
SGTC_2870 9038528 12.99 µM 0.325454887195218 0.359950898107512 no 1183 0.372418410240384 1719 6463316
SGTC_2721 ifenprodil 61.44 µM 0.32536732868111 0.359986901637236 no 1184 0.372451539689044 1820 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor.
SGTC_3104 9120930 49.47 µM 0.323943458455616 0.3605725625741 no 1185 0.372990420697484 1741 17014836
SGTC_127 0180-0333 59.125 µM 0.322884461253575 0.361008357584425 no 1186 0.373391372342388 1789 771601
SGTC_1922 5578187 25 µM 0.322527629710761 0.361155240398152 no 1187 0.373526504827403 1845 1350412
SGTC_2953 9074162 66.49 µM 0.321755640072994 0.361473085059813 no 1188 0.373818911326812 1907 16451992
SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM 0.321089283167199 0.361747515367991 no 1189 0.374071365735402 1840 6710655
SGTC_1115 galangin 695.678 nM 0.320041489739993 0.362179179068397 no 1190 0.374468439503099 1867 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_479 n-linoleoylglycine 10 µM 0.318511491341958 0.362809813520632 no 1191 0.375048489677765 1736 6433346 An anti-infammatory.
SGTC_2437 5741531 144.16 µM 0.318296971142962 0.362898264211964 no 1192 0.37512984080902 1877 2262990
SGTC_603 3794-0023 45.9 µM 0.317825571082528 0.363092656967877 no 1193 0.375308626367631 1849 3802260
SGTC_79 0052-0007 94.094 µM 0.317306504018693 0.363306747124347 no 1194 0.375505521340677 1849 2801472
SGTC_2364 9055074 200 µM 0.317179389889707 0.363359182091136 no 1195 0.375553743818577 1693 6470630
SGTC_961 1252-1571 372 µM 0.316716205211102 0.363550268843626 no 1196 0.37572947568621 1869 6813498
SGTC_1456 k015-0012 13 µM 0.316358459138831 0.363697880160443 no 1197 0.375865221885433 1922 2989616
SGTC_981 1488-1094 54.9 µM 0.315083179191418 0.364224244006614 no 1198 0.376349249804003 1733 3449522
SGTC_483 fpl-64176 144 µM 0.314773853450906 0.364351954922899 no 1199 0.37646668261821 1776 3423
SGTC_3028 9087778 49.47 µM 0.314765657751914 0.364355338875357 no 1200 0.376469794199252 1696 17217395
SGTC_573 3702-0553 84.7 µM 0.314687659502749 0.364387544389912 no 1201 0.376499407434898 1761 1222756
SGTC_1010 4112-3296 15.2 µM 0.314564741938697 0.364438299054317 no 1202 0.376546076454973 1916 704384
SGTC_2591 skatole 100 µM 0.312990579556194 0.365088506195369 no 1203 0.377143909635486 1753 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite.
SGTC_2942 9052777 62.25 µM 0.311593940739467 0.365665712284014 no 1204 0.377674569866051 1771 6469503
SGTC_534 k292-0788 63.4 µM 0.31100160716163 0.365910605232334 no 1205 0.377899699920238 1930 4146317
SGTC_1709 st033179 39.1045 µM 0.307324400372719 0.367432119705461 no 1206 0.379298232479587 1754 573381
SGTC_2576 guaiol 23.12 µM 0.303915909153371 0.368844309640664 no 1207 0.380595978493454 1926 227829
SGTC_1422 4031-0024 15.5 µM 0.303561132777416 0.368991401088124 no 1208 0.38073113326553 1875 782427
SGTC_2266 7929956 200 µM 0.301740300854914 0.369746625505309 no 1209 0.381425021837864 1734 2967153
SGTC_1219 1469-0211 33.1 µM 0.30143137012526 0.369874810319029 no 1210 0.381542788064707 1880 6822282
SGTC_2900 5328528 85.29 µM 0.301377371347612 0.369897217549326 no 1211 0.381563373845393 1726 795359
SGTC_1124 fisetin 1.16336 µM 0.301130356219418 0.369999724108821 no 1212 0.381657546900529 1745 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster.
SGTC_817 1391-0715 46 µM 0.299626166379298 0.370624133279917 no 1213 0.382231161390903 1727 1353946
SGTC_2319 6033012 152.6 µM 0.299048954368386 0.370863832257768 no 1214 0.382451346721216 1721 847246
SGTC_172 1112-0046 2.638 µM 0.298995221368528 0.370886148525734 no 1215 0.382471845835867 1771 2802135 YIL048W NEO1
SGTC_1590 st077108 57.8 µM 0.297850674131034 0.371361602332647 no 1216 0.382908568213266 1910 5489485
SGTC_644 1498-1197 63.3 µM 0.297751501780822 0.371402808551273 no 1217 0.382946416206901 1846 6741615
SGTC_1516 st013856 110 µM 0.297048648536389 0.371694887047066 no 1218 0.383214684120711 1800 5281404 A mutagen and neurotoxin.
SGTC_293 4049-0273 38.5 µM 0.296935863565635 0.371741762980723 no 1219 0.38325773757034 1795 1380311
SGTC_936 3005-4620 401 µM 0.295294306435624 0.372424245442537 no 1220 0.383884532757771 1913 777207
SGTC_2525 harmine 47.85 µM 0.293633547823686 0.373115118896403 no 1221 0.384518968895132 1846 5280953 A monoamine oxidase inhibitor
SGTC_1272 0839-0021 27 µM 0.293310995543329 0.373249347639264 no 1222 0.384642224921652 1817 5027250
SGTC_133 0724-0033 378.92 µM 0.292911336516064 0.373415685361356 no 1223 0.384794961714935 1839 280309
SGTC_2615 purpurogallin-4-carboxylic acid 100 µM 0.291944977169696 0.373817980661051 no 1224 0.385164346942629 1775 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase.
SGTC_2153 5569715 200 µM 0.28994104242756 0.374652656272699 no 1225 0.385930671124415 1817 2054701
SGTC_733 4069-0007 56.1 µM 0.289776126990372 0.374721372802141 no 1226 0.385993756268466 1829 5717425 YNL287W SEC21
SGTC_1378 2093-0007 380 nM 0.288620377667571 0.375203058900302 no 1227 0.386435949860913 1779 3618014
SGTC_1556 plumbagin 1.48 µM 0.288396866967592 0.375296234803422 no 1228 0.386521482850089 1857 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_742 0kpi-0133 140 µM 0.287338566081999 0.375737512121182 no 1229 0.386926547820818 1926 2728852
SGTC_1312 1218-2183 165 µM 0.28714093261394 0.375819936932426 no 1230 0.387002205751775 1865 6744073
SGTC_3047 9092122 49.47 µM 0.286138630255091 0.37623804329547 no 1231 0.387385972613656 1761 17173831
SGTC_1221 2958-7315 257 µM 0.285890198541025 0.376341698064024 no 1232 0.387481110507859 1832 4562705
SGTC_323 4013-0906 34.3 µM 0.284836221415419 0.376781554850258 no 1233 0.387884810242232 1932 2910086
SGTC_2779 methotrexate 400 µM 0.284567613450462 0.376893678748445 no 1234 0.387987713243616 1897 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2
SGTC_410 α-linolenic acid 100 µM 0.283505746210189 0.377337031117863 no 1235 0.388394588722804 1887 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_2892 9047358 58.44 µM 0.282563359350781 0.377730633332745 no 1236 0.388755785544701 1795 6466771
SGTC_1226 3909-7979 35.4 µM 0.282433534824655 0.377784866483276 no 1237 0.388805552067223 1911 6615510
SGTC_1829 berberine 14.4 µM 0.282115895854007 0.37791756776198 no 1238 0.388927322476535 1922 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_1198 1612-1005 86.7 µM 0.281078303645486 0.378351147049544 no 1239 0.389325170899546 1910 6998509
SGTC_1547 harmine 94.2 µM 0.280829997388173 0.378454929676981 no 1240 0.389420397254373 1790 5280953 A monoamine oxidase inhibitor YHR072W ERG7
SGTC_1951 sophoraflavanone G 9.2 µM 0.27944963199772 0.379032029880476 no 1241 0.389949893330527 1753 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity.
SGTC_2692 st077426 47.7 µM 0.277170058515499 0.379985659101357 no 1242 0.390824764567086 1909 25238571
SGTC_2296 7971656 126.45 µM 0.276707407860584 0.380179292167267 no 1243 0.391002391624962 1789 666570
SGTC_2274 7947094 46.08 µM 0.27038210587159 0.382829612414611 no 1244 0.393433152525768 1855 2971028
SGTC_1703 st026983 48.3 µM 0.270256929390217 0.382882117591455 no 1245 0.393481299087966 1948 1104023
SGTC_724 3910-0327 137 µM 0.269875258736764 0.383042222329015 no 1246 0.393628110916177 1784 2885483
SGTC_945 3381-0768 11.3 µM 0.269857804974707 0.383049544381173 no 1247 0.393634824968626 1937 1126236 YIL048W NEO1
SGTC_245 methotrexate 289.6 µM 0.268824718213403 0.383483010404679 no 1248 0.394032285454756 1882 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2
SGTC_1725 st036284 20.55 µM 0.267325335629407 0.384112385782157 no 1249 0.394609340673415 1975 707914
SGTC_2203 7227154 166.4 µM 0.265847865881233 0.38473286218757 no 1250 0.39517818877888 1858 896304
SGTC_2567 aureobasidin a 60 nM 0.265797640470911 0.384753959989714 no 1251 0.395197530252431 1852 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1
SGTC_3170 9103054 49.47 µM 0.264981240204412 0.385096946793461 no 1252 0.395511956776418 1817 16432970
SGTC_2045 5106652 78.05 µM 0.264672846154184 0.385226532987759 no 1253 0.395630748665494 1926 673349
SGTC_2602 kawain 100 µM 0.264625881763362 0.385246268399604 no 1254 0.395648839971583 1928 5369129
SGTC_2800 7887935 81.82 µM 0.263363328275233 0.385776930815843 no 1255 0.396135276465453 1858 2961002
SGTC_2230 bromochlorosalicylanilide 954.5 nM 0.261722809500306 0.386466774719295 no 1256 0.396767576947762 1960 77254
SGTC_514 4466-0038 2.65 nM 0.261404833484195 0.38660052635036 no 1257 0.396890165004886 1855 5722064
SGTC_1689 st020265 53.493 µM 0.260469091592627 0.386994209625016 no 1258 0.397250977011419 1961 5758320 YPR016C TIF6
SGTC_2510 benzyl isothiocyanate 8.31 µM 0.260454638719196 0.387000291119133 no 1259 0.397256550574402 1846 2346 DNA damaging agent; causes G2/M arrest.
SGTC_455 paf C-16 10 µM 0.259869914317873 0.387246355269169 no 1260 0.397482059530738 1839 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis.
SGTC_3134 9127454 49.47 µM 0.258614919438055 0.38777463600809 no 1261 0.397966185365429 1906 24262820
SGTC_136 0097-0015 404.482 µM 0.257306863485311 0.388325473576639 no 1262 0.398470947247748 1985 4861337
SGTC_10 0279-0212 42.575 µM 0.256494686046689 0.388667604083077 no 1263 0.398784441577767 1853 39851 YBR002C RER2
SGTC_3094 9117742 49.47 µM 0.255178169081319 0.389222371472821 no 1264 0.399292745797485 1880 17149698
SGTC_2726 cimetidine 79.27 µM 0.25450254517256 0.389507160568358 no 1265 0.399553669025479 1947 2756 A P450 inhibitor, histamine H2-receptor antagonist.
SGTC_2495 cafestol 54.53 µM 0.253475032344858 0.389940391654525 no 1266 0.399950576306327 1903 16667697 An anti-infammatory.
SGTC_1122 capsaicin 818.572 nM 0.252838949997027 0.390208652152118 no 1267 0.400196333800238 1920 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_2344 7990960 76.95 µM 0.252557822705904 0.390327231059971 no 1268 0.400304963058745 1833 140813
SGTC_2612 dictamnine 15.46 µM 0.252301034154114 0.390435552855117 no 1269 0.40040419442403 1865 68085 A quinoline derivative and established mutagen. YOR116C RPO31
SGTC_2318 6029776 164 µM 0.252092444197582 0.390523549170015 no 1270 0.400484805032683 1902 818325
SGTC_2178 5812956 200 µM 0.251511390673616 0.390768703512975 no 1271 0.400709378348414 1894 5403383
SGTC_962 1254-0300 21.5 µM 0.251102515918679 0.390941239337999 no 1272 0.400867425395392 1854 7340576
SGTC_1463 k081-0032 34.1 µM 0.251010240417099 0.390980180466468 no 1273 0.400903095948252 1879 977755
SGTC_2341 7987486 176.74 µM 0.25042845310627 0.391225725334137 no 1274 0.401128014038771 2008 1258686
SGTC_1244 0416-0015 52.5 µM 0.249892951623911 0.391451773471098 no 1275 0.401335067064862 1849 96201
SGTC_3102 9121669 49.47 µM 0.249546214148623 0.391598159311657 no 1276 0.401469148784928 1878 41905072
SGTC_1163 k060-0048 49.9 µM 0.248367572776337 0.392095873517425 no 1277 0.401925010414614 1841 6809982
SGTC_2141 5621638 7.665 µM 0.248047718776364 0.392230971293093 no 1278 0.402048742990013 1976 2856238
SGTC_9 0092-0002 10.449 µM 0.247375853873596 0.392514791345696 no 1279 0.402308679697168 1898 759368
SGTC_2911 7942208 15.64 µM 0.246298538929531 0.392970007454638 no 1280 0.402725570440971 1835 1243384
SGTC_2275 7947463 200 µM 0.246048117102707 0.393075843420239 no 1281 0.402822492545896 1987 1225414
SGTC_331 k048-0133 24.5 µM 0.245792728875655 0.393183786479835 no 1282 0.402921342974295 1840 6813582
SGTC_1748 st037455 53.6035 µM 0.244818919873076 0.39359545444646 no 1283 0.403298321846667 1898 580690
SGTC_3249 9135183 49.47 µM 0.243347787028017 0.394217586546867 no 1284 0.403867994023009 1920 4902779
SGTC_2077 5212015 200 µM 0.241404047763191 0.395039994494763 no 1285 0.404620987924598 1948 780900
SGTC_2656 pseudo-anisatin 100 µM 0.241304610835631 0.395082079475058 no 1286 0.40465951876845 1904 6708809 A neurotoxin.
SGTC_942 3253-1115 227 µM 0.241061694830876 0.395184894669175 no 1287 0.404753650248793 1973 46497897
SGTC_168 3970-0862 530.542 µM 0.240550235661521 0.395401395707974 no 1288 0.404951861910249 1897 3135186
SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM 0.239826907560518 0.395707636125625 no 1289 0.40523222320099 1894 1377
SGTC_197 4544-0043 41.561 µM 0.238688055236718 0.396189930352046 no 1290 0.405673739812909 1925 896523
SGTC_531 3788-1495 174 µM 0.238500587024283 0.396269336791414 no 1291 0.405746430053822 1836 2896655
SGTC_2883 9059145 45.46 µM 0.238051167705 0.396459716118771 no 1292 0.405920704286753 1853 16476510
SGTC_1228 0124-0032 52.5 µM 0.237518205092314 0.396685517368359 no 1293 0.406127398806598 1959 X1228
SGTC_2213 7173844 200 µM 0.236250876286889 0.397222587918195 no 1294 0.406619001532389 1885 892728
SGTC_34 0469-0683 81.75 µM 0.235584922783544 0.39750488491707 no 1295 0.406877387037352 1939 3690923
SGTC_1236 0330-0013 258 µM 0.234905372725865 0.397793000826507 no 1296 0.40714108970463 1874 4617066
SGTC_893 0958-0369 48.9 µM 0.234446457904077 0.397987603268642 no 1297 0.407319197629363 2032 6819948
SGTC_1834 st055981 52.8 µM 0.232723948906184 0.398718257801036 no 1298 0.407987885608816 1995 471719 YDL150W RPC53
SGTC_882 0843-0131 351 µM 0.232000741503761 0.39902513419342 no 1299 0.408268718938656 2020 5425421
SGTC_411 enrofloxacin 100 µM 0.231942665785183 0.399049779996089 no 1300 0.408291272741289 2050 71188 A bacterial gyrase inhibitor.
SGTC_1123 mangostin 811.285 nM 0.231763671581417 0.399125742944737 no 1301 0.40836078735111 1862 5281650 An antioxidant.
SGTC_621 3584-0052 32.1 µM 0.23087531734856 0.399502806079667 no 1302 0.408705833321526 2014 2273927
SGTC_1928 4'-methoxychalcone 40.3 µM 0.230799085045882 0.399535167354817 no 1303 0.408735446037191 2056 641818
SGTC_2145 5634607 200 µM 0.230602176648857 0.399618759874515 no 1304 0.408811938231894 1853 308662
SGTC_711 k292-0785 179 µM 0.230512347658265 0.399656896047377 no 1305 0.408846834884098 1906 4146315
SGTC_1426 4048-4480 71.7 µM 0.2300957910179 0.399833754313462 no 1306 0.409008667719365 1970 14224343
SGTC_3085 9117376 49.47 µM 0.228855231245937 0.40036058279912 no 1307 0.409490718704469 1917 16480349
SGTC_27 0485-0001 32.618 µM 0.22859335860032 0.400471815461202 no 1308 0.409592493487516 2004 2054479
SGTC_526 4469-0568 170 µM 0.228540579319968 0.40049423489291 no 1309 0.409613006485499 1829 2901964
SGTC_445 e6 berbamine 66 µM 0.228424047504409 0.40054373610503 no 1310 0.409658298181893 1897 6610268 A calcium/calmodulin antagonist.
SGTC_2128 5255449 168.493 µM 0.228317300018182 0.400589082462131 no 1311 0.409699788121869 1884 736008
SGTC_1442 4112-3290 3 µM 0.227595792424963 0.400895614159707 no 1312 0.409980245637796 1940 704353
SGTC_1787 fluconazole 80 µM 0.225128350244754 0.401944364351843 no 1313 0.410939713356434 1930 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C
SGTC_3056 9094900 49.47 µM 0.224812943364054 0.402078474511298 no 1314 0.411062398229102 1826 25236784
SGTC_490 phenamil 164 µM 0.22426307825631 0.402312303241098 no 1315 0.411276301901603 2008 4755 Irreversibly blocks amiloride-sensitive Na+ channels.
SGTC_1485 3909-9022 254 µM 0.224210603259899 0.402334619927674 no 1316 0.411296716641493 2003 714516
SGTC_2360 9040895 200 µM 0.222518320225503 0.403054488207394 no 1317 0.411955206629106 1874 4914414
SGTC_646 4092-0839 27.3 µM 0.22202595663965 0.403263993100236 no 1318 0.41214683854832 1976 877796
SGTC_1892 st058411 7.36 µM 0.219363343723842 0.404397437202231 no 1319 0.413183511044992 2018 3934738
SGTC_1229 0139-0193 12.2 µM 0.218879998974637 0.404603277955225 no 1320 0.413371763605762 2041 3090752
SGTC_3135 9127742 49.47 µM 0.218684614338141 0.404686493392322 no 1321 0.413447867446029 1875 3643468
SGTC_1038 k292-0204 154 µM 0.218553478418744 0.404742347350392 no 1322 0.413498947733569 1857 4454212
SGTC_1499 4480-0877 67.3 µM 0.217764411772551 0.405078470847723 no 1323 0.413806337200624 2012 2861909
SGTC_2441 5730946 39.09 µM 0.216854038149008 0.405466355212351 no 1324 0.414161048733193 1978 1774275
SGTC_764 1951-2361 146 µM 0.216745239026516 0.405512717649929 no 1325 0.414203445143401 1831 5438930
SGTC_585 0kpi-0023 191 µM 0.216105807520949 0.405785224588864 no 1326 0.414452636463701 2010 64601
SGTC_3173 9105693 49.47 µM 0.215159859478513 0.406188443584767 no 1327 0.414821342735591 1978 17096658
SGTC_1956 st077085 54 µM 0.213632805057666 0.406839574314475 no 1328 0.415416707593451 1893 24208685
SGTC_667 1498-1044 59 µM 0.21130916783079 0.407830858882027 no 1329 0.416323014773258 1928 6739982
SGTC_920 mycophenolic acid 780.421 nM 0.211025293800992 0.40795200269185 no 1330 0.416433767081056 1883 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_1253 0550-0034 176 µM 0.209133459012338 0.408759571187986 no 1331 0.417172027827265 1932 5969915
SGTC_177 1327-0068 8.361 µM 0.208269447975183 0.409128521144016 no 1332 0.417509292780189 2007 15389900 YOR207C | YLR033W RET1 | RSC58
SGTC_2752 diclazuril 33.15 µM 0.208225788014203 0.409147166958577 no 1333 0.417526336970286 2059 456389 An antifungal agent for coccidioides. YHR062C RPP1
SGTC_2155 5570423 76 µM 0.207966822592936 0.409257767278651 no 1334 0.417627436348131 1913 797402
SGTC_3027 9089541 49.47 µM 0.207254973232693 0.409561824857788 no 1335 0.417905368387322 1929 9943819
SGTC_2156 5649887 115 µM 0.207244163728898 0.409566442422366 no 1336 0.41790958912958 2040 54680440 YKL052C | YBR257W ASK1 | POP4
SGTC_1144 3486-0183 12.5 µM 0.207220022473926 0.40957675504129 no 1337 0.417919015499743 1950 6744069
SGTC_854 0422-0053 192 µM 0.206726893699964 0.409787422607084 no 1338 0.418111576462963 2018 3596728
SGTC_301 4119-0100 24.5 µM 0.206404073801567 0.409925347311317 no 1339 0.418237644456255 1915 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1
SGTC_491 tetrandrine 80.3 µM 0.204559299214866 0.410713740034015 no 1340 0.418958228707502 2021 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_1175 0741-0056 27.6 µM 0.204497982973565 0.410739950684595 no 1341 0.418982184022978 2023 765927
SGTC_184 1494-0393 24.714 µM 0.204123085266411 0.410900215630368 no 1342 0.419128657339465 1876 3090647
SGTC_928 2764-0428 58.7 µM 0.204061984716641 0.410926336902528 no 1343 0.419152530514598 1961 662578
SGTC_2405 ticlatone 3.52 µM 0.203828045308057 0.411026352663829 no 1344 0.4192439379499 1798 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W
SGTC_2863 9028737 58.44 µM 0.203748847351505 0.41106021335718 no 1345 0.419274884053521 2085 6460917
SGTC_374 0880-0231 82.3 µM 0.203563183790042 0.411139595488889 no 1346 0.419347432880125 2011 6833587
SGTC_768 0384-0033 77.3 µM 0.203311641793869 0.411247150343911 no 1347 0.419445728358925 1867 3965305 YMR134W ERG29
SGTC_2167 5876490 200 µM 0.203132614327611 0.411323703348078 no 1348 0.419515690278342 2054 686534
SGTC_363 0455-0021 3.06 µM 0.2015223138959 0.412012426979322 no 1349 0.420145091676426 1944 4597466
SGTC_2074 5212007 75.395 µM 0.201332275499642 0.412093724107525 no 1350 0.420219383516759 2092 758611
SGTC_1772 st048439 82.2 µM 0.201037770689317 0.412219718706585 no 1351 0.420334520098781 1923 2927068 YDL195W SEC31
SGTC_675 1309-0189 238 µM 0.200784184552418 0.412328214791182 no 1352 0.420433664998105 1933 4246530
SGTC_1797 st048695 56.8 µM 0.200724943772456 0.41235356175083 no 1353 0.420456827169963 2056 592262 YIL048W NEO1
SGTC_2578 7,8-dihydroxyflavone 64.44 µM 0.19927658103218 0.412973376588171 no 1354 0.421023198703889 1848 1880 Intensifies effect of antibiotics on Staphylococcus aureus.
SGTC_422 cantharidin 155 µM 0.198597369163902 0.413264114520787 no 1355 0.421288855861701 1856 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_1180 1193-0155 285 µM 0.198521325889033 0.413296667953293 no 1356 0.421318600567022 1939 2921347
SGTC_2517 totarol 10 µM 0.197800952655757 0.413605082704529 no 1357 0.421600400393784 1894 460178 An antibacterial membrane disruptor. YGL001C ERG26
SGTC_3103 9120822 49.47 µM 0.197501209609819 0.413733427976247 no 1358 0.421717667475426 2048 17141819
SGTC_3154 9100113 49.47 µM 0.196279856605103 0.414256487324275 no 1359 0.422195563415172 1915 25237525
SGTC_2006 4011487 200 µM 0.193931774209962 0.415262508874893 no 1360 0.423114651878521 2032 45595294
SGTC_1106 tegaserod maleate 11.7 µM 0.193393620160422 0.415493156216622 no 1361 0.423325355749293 1971 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation.
SGTC_2753 fluvastatin 17.09 µM 0.192572836770413 0.415844991665056 no 1362 0.423646759915017 1982 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5
SGTC_1857 st056007 79.3 µM 0.192227169504617 0.415993184943847 no 1363 0.423782132279142 2066 619834
SGTC_691 1548-0686 185 µM 0.192156403495402 0.416023524977178 no 1364 0.42380984721351 1920 46495133
SGTC_218 alverine citrate 93.75 µM 0.191716206282046 0.416212265209421 no 1365 0.423982255345274 2052 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_1091 telmisartan 47.6 µM 0.191253894280534 0.416410508245635 no 1366 0.424163340644568 2049 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension.
SGTC_2189 6047310 154.431 µM 0.190078528894398 0.416914609845475 no 1367 0.424623797405037 1969 711535
SGTC_447 ml7 120 µM 0.189873600791645 0.417002515321166 no 1368 0.424704089824344 2095 4216 Selective myosin light chain kinase inhibitor.
SGTC_2684 capsaicin 100 µM 0.18959250552421 0.417123100032992 no 1369 0.42481423021049 2003 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_252 miconazole 1.30953 nM 0.189563896127991 0.417135373376325 no 1370 0.424825440440135 2040 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_1287 0971-0001 34.6 µM 0.18835522721845 0.417653962258385 no 1371 0.425299097476783 1982 4665869
SGTC_1519 esterone 74 µM 0.187478732557463 0.418030118828516 no 1372 0.425642648504628 1855 698 A steroid.
SGTC_1673 st016611 27.3 µM 0.186504439581614 0.418448334539134 no 1373 0.426024598828132 2051 5226799
SGTC_1490 4089-0339 670 nM 0.1864455563634 0.4184736131472 no 1374 0.426047684938047 2073 742542
SGTC_3055 9094636 49.47 µM 0.184619348676933 0.419257772073646 no 1375 0.426763804386374 2028 25236176
SGTC_2543 pimpinellin 60.67 µM 0.184087946208173 0.419486012426669 no 1376 0.426972231207298 1927 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo.
SGTC_921 1561-0023 372 µM 0.183718524296978 0.419644697185697 no 1377 0.427117137987856 2004 24050882
SGTC_509 pifithrin 175 µM 0.181217314835777 0.420719431334192 no 1378 0.428098502166099 2088 4817 A p53 inhibitor.
SGTC_265 mycophenolic acid 32.932 µM 0.180464662546151 0.421042951405185 no 1379 0.428393897054736 2075 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1
SGTC_790 1575-0012 79.1 µM 0.179248657099201 0.42156575178375 no 1380 0.428871229758562 2101 378741 YLR208W SEC13
SGTC_2938 9059746 27.26 µM 0.178601546316838 0.42184402223879 no 1381 0.429125290113946 2027 6471769
SGTC_638 3970-0837 4.09 µM 0.178593840257083 0.421847336232556 no 1382 0.429128315745655 1938 4118451 YLR208W SEC13
SGTC_590 k048-0076 22.4 µM 0.178418886139046 0.421922576802616 no 1383 0.429197009134449 2092 6832814
SGTC_1870 st057514 26.5 µM 0.177858534740265 0.422163580060352 no 1384 0.429417038020685 1972 5393161
SGTC_107 0358-0022 2.6945 µM 0.177420616695948 0.422351945875479 no 1385 0.429589007210032 2085 521106 YGL093W | YPR107C SPC105 | YTH1
SGTC_2981 9013952 38.96 µM 0.176943489244556 0.422557197418038 no 1386 0.429776389032505 1861 2996344
SGTC_1989 st071868 50.2 µM 0.1767542262179 0.422638620754508 no 1387 0.429850722510515 2101 16414057
SGTC_1559 coumarin 343 70.1 µM 0.176645175558187 0.422685537222232 no 1388 0.429893553530943 2072 108770 A hepatotoxic, DNA x-linker.
SGTC_287 k060-0039 29.6 µM 0.176561414066134 0.422721574368324 no 1389 0.429926452472459 2101 5861974
SGTC_2772 vinpocetine 57.06 µM 0.175924932374419 0.422995432333509 no 1390 0.430176458812067 2073 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor.
SGTC_2459 5811157 9.22 µM 0.175893941452936 0.423008767699192 no 1391 0.430188632582929 2118 2870684 YBR192W RIM2
SGTC_2616 abietic acid 100 µM 0.175422210870821 0.423211763827355 no 1392 0.4303739447143 2133 6708678 Abietic acid is an inhibitor of 5α-reductase.
SGTC_2742 clothiapine 36.27 µM 0.175367739010241 0.423235205590619 no 1393 0.430395344138535 2106 16351 An atypical antipsychotic. YIL048W NEO1
SGTC_1425 4048-4433 7.33 µM 0.174393060168954 0.423654700874436 no 1394 0.430778283968349 2080 23734946
SGTC_3294 9122953 26.2835 µM 0.173822468934341 0.423900319734072 no 1395 0.431002492771315 2064 16459826
SGTC_2844 9010103 25.97 µM 0.173282379972166 0.424132835709477 no 1396 0.431214736463032 1973 2480525
SGTC_2717 st081029 62.2815 µM 0.172689967657687 0.424387908001579 no 1397 0.431447564982361 2112 5292846
SGTC_40 0327-0103 19.753 µM 0.171065452425496 0.425087530376471 no 1398 0.432086150191154 1977 409036
SGTC_2919 7978188 46.38 µM 0.170631536478716 0.425274442955162 no 1399 0.432256749519746 2105 2980291
SGTC_2718 lomofungin 53.02 µM 0.170207823807095 0.425456976605565 no 1400 0.432423349496481 2085 5351222 A RNA synthesis inhibitor.
SGTC_2592 piperlongumine 83.33 µM 0.169864754628281 0.425604781083768 no 1401 0.432558249987967 1963 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_2996 9066192 71.4286 µM 0.169028095771429 0.425965282576804 no 1402 0.432887271061476 1945 6472854
SGTC_2086 5274770 176.623 µM 0.168720756996545 0.426097724972561 no 1403 0.4330081455615 1992 689278
SGTC_2583 asiatic acid 100 µM 0.166754767334392 0.426945131233988 no 1404 0.433781505341923 2041 5320556 A kinase inhibitor; arrests cells at G2/M.
SGTC_2782 7736369 71.43 µM 0.166555733617613 0.427030940183263 no 1405 0.433859813259812 1981 2950836 YOL077C BRX1
SGTC_1754 st042065 16.137 µM 0.166478699178412 0.427064152791209 no 1406 0.433890122422299 2028 1126236 YIL048W NEO1
SGTC_2989 9073649 71.4286 µM 0.166390270423005 0.427102278579044 no 1407 0.43392491515212 2155 21367202
SGTC_2573 2',4'-dihydroxychalcone 15.04 µM 0.165849737218973 0.42733534260896 no 1408 0.434137601725255 2040 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_226 1,3-diallylurea 8.28947 mM 0.164210216246098 0.428042416737362 no 1409 0.4347828294394 2065 74537 YKL182W FAS1
SGTC_2380 9035439 200 µM 0.163595933014224 0.428307397526676 no 1410 0.435024623277414 2082 6462575
SGTC_1675 st018485 24.5 µM 0.162691405092124 0.428697638770284 no 1411 0.435380707285149 1974 3323024
SGTC_2342 7990637 118.86 µM 0.162626293414561 0.428725732650743 no 1412 0.435406341716642 2018 2033102 YER133W GLC7
SGTC_104 0074-0074 590.992 µM 0.161807952304217 0.429078854858194 no 1413 0.435728545269367 2123 3943124
SGTC_1119 parthenolide 318.541 nM 0.160244238992307 0.429753770120885 no 1414 0.436344340977392 2047 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs.
SGTC_2965 9082772 38.63 µM 0.159924369414412 0.42989185458847 no 1415 0.436470325783603 2144 16459634
SGTC_947 3447-0010 211 µM 0.158674601721142 0.430431448745566 no 1416 0.436962624760207 2122 748350
SGTC_2671 danthron 100 µM 0.158333250637337 0.430578851608462 no 1417 0.437097104187938 2036 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin.
SGTC_1586 deoxycorticosterone acetate 53.7 µM 0.157709947967751 0.430848032275286 no 1418 0.437342680628319 2103 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE.
SGTC_1080 nisoldipine 24.4 µM 0.157671372323127 0.430864692682983 no 1419 0.437357879928767 2026 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class.
SGTC_396 dithiazanine 1.25 µM 0.157019113250508 0.431146414994429 no 1420 0.437614892377003 1970 10578 An antihelmenthic.
SGTC_1910 st062352 60.4 µM 0.156739491304326 0.431267199431072 no 1421 0.43772508108294 2040 2245730
SGTC_2646 retinol 96.75 µM 0.156329599521868 0.431444266346896 no 1422 0.43788661305745 2081 445354 A vitamin A analog and teratogen.
SGTC_3331 9141060 1.957 µM 0.156207287662487 0.431497105850556 no 1423 0.437934816264759 1979 4906567 YPR165W RHO1
SGTC_736 0958-0254 92.6 µM 0.155815403957865 0.431666410362437 no 1424 0.438089264163492 2074 6812352
SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM 0.155644407940403 0.431740289268943 no 1425 0.438156659500411 2028 4213774
SGTC_3301 9125354 19.7965 µM 0.155204764435551 0.431930248398224 no 1426 0.438329946164359 2036 41905162
SGTC_964 1287-0107 19.4 µM 0.153165660469512 0.432811500109214 no 1427 0.439133818536782 2118 51516812 YPR165W RHO1
SGTC_1048 3161-0300 24.5 µM 0.152946626607278 0.432906181237569 no 1428 0.439220182864182 2105 2165101
SGTC_3098 9119039 49.47 µM 0.152846985809283 0.432949253949511 no 1429 0.439259471858972 2162 17161528
SGTC_1688 st021091 57.6 µM 0.151809997909479 0.433397570144703 no 1430 0.439668398172796 2164 3656366
SGTC_1749 st037932 54.2 µM 0.150182212869806 0.434101475604691 no 1431 0.440310429401481 2034 594497
SGTC_3252 9135871 49.47 µM 0.149994773877561 0.434182543582995 no 1432 0.440384369227849 2109 17682838
SGTC_2822 7994718 71.43 µM 0.149060210997319 0.434586786332674 no 1433 0.440753061043791 2135 1018011
SGTC_1831 st055328 12 µM 0.148552214060707 0.434806547811138 no 1434 0.440953491077965 2134 1103068
SGTC_3033 9090887 49.47 µM 0.148544946922805 0.434809691749956 no 1435 0.440956358434835 2023 19325384
SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM 0.148432992393129 0.434858126495653 no 1436 0.441000532143391 2062 6708784 An antioxidant flavonoid
SGTC_2474 5321570 43.32 µM 0.147998650024244 0.43504604472875 no 1437 0.441171916817423 2126 2841384
SGTC_1135 dihydrocapsaicin 536.708 nM 0.147738247431916 0.435158714952463 no 1438 0.441274672873384 1992 107982 A Capsaicinoid.
SGTC_2124 5246320 200 µM 0.146550162827783 0.435672838558173 no 1439 0.441743546563015 2056 579342
SGTC_1182 1222-0449 220 µM 0.146450763478976 0.435715856893737 no 1440 0.441782777899828 2085 658318
SGTC_1342 1486-1464 234 µM 0.145332152389072 0.43620002494097 no 1441 0.442224315134597 2065 3253938
SGTC_3164 9100705 49.47 µM 0.145216770046581 0.4362499712922 no 1442 0.442269862849822 2149 17174235
SGTC_2085 5307070 144.047 µM 0.145148418415348 0.436279559614251 no 1443 0.442296845333493 2017 2840351
SGTC_3019 9081971 49.47 µM 0.144390391445555 0.436607721168457 no 1444 0.442596101909233 2150 16451803
SGTC_1137 ixabepilone 100 µM 0.144005843310583 0.43677421467706 no 1445 0.442747927719987 2062 154225 A novel microtubule stabilizer.
SGTC_1498 4478-3555 97.6 µM 0.143562665701623 0.436966106223885 no 1446 0.442922911820523 2166 3437919
SGTC_1700 st030840 7.9285 µM 0.143511359939307 0.436988322073206 no 1447 0.442943170090445 2160 5499307
SGTC_1082 camptothecin 424.86 nM 0.142319001207032 0.437504679787561 no 1448 0.443414019249807 2011 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_676 falcarinol 140 µM 0.142164647352814 0.437571531400925 no 1449 0.443474977720183 2159 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer.
SGTC_1641 st009299 47.1 µM 0.141684941151894 0.437779306504713 no 1450 0.443664435076937 2167 4046054
SGTC_3245 9134821 49.47 µM 0.140142321316044 0.438447577309674 no 1451 0.444273771470753 2060 17014901
SGTC_153 4077-0274 519.67 µM 0.139708741014854 0.438635438199235 no 1452 0.444445059907521 2169 3121976
SGTC_2544 sphondin 68.51 µM 0.139212638281152 0.438850405653563 no 1453 0.444641060923824 2139 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31
SGTC_1714 st033236 13.627 µM 0.138425377494853 0.439191572496173 no 1454 0.444952120869233 2121 2916566
SGTC_1353 1498-1206 8.11 µM 0.138090645083767 0.439336645626999 no 1455 0.445084389543246 2116 6756808
SGTC_1543 azetidyl-2-carboxylic acid 198 µM 0.137933286555961 0.439404847678467 no 1456 0.445146571485049 2140 16486 A toxic proline analog.
SGTC_1457 k015-0032 57.3 µM 0.137280725148941 0.439687698848964 no 1457 0.445404452642948 2054 4302660
SGTC_2292 7671323 168.05 µM 0.136684131377267 0.439946317928697 no 1458 0.445640236562794 2041 937504
SGTC_70 0141-0289 43.283 µM 0.135471433421532 0.440472092584171 no 1459 0.446119574424678 2062 352408
SGTC_3052 9092717 49.47 µM 0.135347389496588 0.440525878728431 no 1460 0.446168609180448 2066 25237534
SGTC_1660 st012960 28.1 µM 0.135240153331261 0.4405723778179 no 1461 0.446211000466306 2074 24207266
SGTC_620 0109-0052 432 µM 0.135060429733359 0.440650310301358 no 1462 0.446282047973473 2173 493037
SGTC_203 k066-0004 30.888 µM 0.134737361736756 0.440790406148962 no 1463 0.446409766064777 2177 6795412
SGTC_1619 st003326 88.7 µM 0.134244650530369 0.441004080678826 no 1464 0.446604559707472 2172 2849032
SGTC_312 4092-0653 6.84 µM 0.13417376756589 0.441034821975016 no 1465 0.446632584387178 2139 1148278
SGTC_398 bronopol 33.3 µM 0.134112782987369 0.441061270715705 no 1466 0.446656695799737 2071 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them.
SGTC_1205 4161-2785 76 µM 0.133672539427915 0.441252210182447 no 1467 0.446830760305707 1971 3498106
SGTC_2547 epiafzelechin trimethyl ether 100 µM 0.133284968717128 0.441420316040778 no 1468 0.446984007379968 2186 6708630 An antioxidant.
SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM 0.133065139000572 0.441515670206788 no 1469 0.447070932486054 2016 2374 Ca(2+)-ATPase inhibitor.
SGTC_567 1080-0542 68.4 µM 0.128704382835774 0.443407901739776 no 1470 0.448795783628151 2184 5950415
SGTC_2634 4'-methoxyflavone 100 µM 0.128358885902465 0.443557876505293 no 1471 0.448932483121642 2052 77793 From seeds of Psoralea corylifolia (Fabaceae)
SGTC_1683 st010134 710 nM 0.127317024373912 0.444010181014492 no 1472 0.449344743227208 2067 3818134
SGTC_2507 purpurin 79.67 µM 0.127020060765543 0.444139115540746 no 1473 0.449462260478771 2069 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1
SGTC_2484 5809818 12.04 µM 0.126913359519518 0.444185444125087 no 1474 0.449504486389446 2101 2870548
SGTC_3189 9110682 49.47 µM 0.126844996790419 0.444215126920315 no 1475 0.449531540530531 2068 17122418
SGTC_1847 st056231 15 µM 0.126498437033504 0.444365606447402 no 1476 0.449668693087709 2183 5393180
SGTC_2197 6588183 93.1375 µM 0.126190979102394 0.444499114305854 no 1477 0.449790375958275 2147 884136
SGTC_2838 9002687 71.43 µM 0.125711517669403 0.444707324030804 no 1478 0.449980142209536 2005 6457060
SGTC_679 0422-0091 41.4 µM 0.124226433142553 0.445352329695742 no 1479 0.450567996859842 2116 627384 YHR062C RPP1
SGTC_1364 1653-0028 37.6 µM 0.123285630184845 0.445761016585529 no 1480 0.450940459736828 2106 5718652
SGTC_1809 st050081 57.6 µM 0.122359948951022 0.446163190824101 no 1481 0.45130697810881 2151 5036894
SGTC_1852 st056254 31.4 µM 0.122195138312177 0.446234800768184 no 1482 0.451372238333773 2104 442583
SGTC_2285 7945142 200 µM 0.121554376842836 0.446513227184787 no 1483 0.451625973732472 2102 2970608
SGTC_2016 5121758 140 µM 0.11986125025699 0.447249058341598 no 1484 0.452296530464348 2203 2795203
SGTC_988 1497-1057 103 µM 0.119783288281549 0.447282944932979 no 1485 0.452327410318186 2218 3533044
SGTC_827 3253-0474 693 µM 0.118209136627383 0.447967240401597 no 1486 0.452950975367886 2189 5402065
SGTC_3188 9110789 49.47 µM 0.118139708449205 0.447997424929555 no 1487 0.452978480474438 2180 849217
SGTC_3238 9133470 49.47 µM 0.117423036263905 0.448309022204344 no 1488 0.45326241502411 2203 3534688
SGTC_2964 9083345 53.42 µM 0.116777166197738 0.448589863211555 no 1489 0.453518319332791 2086 17741579
SGTC_1884 5633444 25 µM 0.115964457756885 0.448943286448824 no 1490 0.45384035515247 2122 5724239
SGTC_1625 st003711 30.1 µM 0.115926817848902 0.448959655932695 no 1491 0.453855270707667 2164 24207034 YER133W GLC7
SGTC_2143 5623677 140.463 µM 0.11561991820651 0.449093128912805 no 1492 0.453976888165015 2189 5375313
SGTC_1150 3909-7983 10.9 µM 0.114806682280678 0.449446839198745 no 1493 0.454299176194253 2063 23965914
SGTC_1729 st035615 45.989 µM 0.114121962224807 0.449744683726684 no 1494 0.454570556311335 2050 17385451
SGTC_1130 3454-2858 15.9 µM 0.110981366860199 0.45111116304221 no 1495 0.455815561267724 2031 715628 YIL048W NEO1
SGTC_1018 4259-0013 28.1 µM 0.11074915133224 0.451212223692076 no 1496 0.455907634277971 2108 6801262
SGTC_615 k087-0205 167 µM 0.109500131730467 0.451755853542129 no 1497 0.45640290864618 2142 9642773
SGTC_3236 9132701 49.47 µM 0.108175450567183 0.452332513573786 no 1498 0.456928259136332 2104 24282524
SGTC_1369 1866-0067 208 µM 0.108150670925847 0.452343301606021 no 1499 0.456938087124444 2195 3531355
SGTC_1925 st057770 10.1 µM 0.10795326039225 0.452429247253665 no 1500 0.457016384128415 1975 5989122
SGTC_2479 5617353 43.85 µM 0.107181602250884 0.452765221590723 no 1501 0.457322455310477 2170 2731746
SGTC_982 1491-0518 27.5 µM 0.106918034380744 0.452879984883169 no 1502 0.457427002917644 2125 3091256
SGTC_2582 agaric acid 100 µM 0.106295705569384 0.453150976242923 no 1503 0.457673869373821 2163 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase.
SGTC_3079 9117512 49.47 µM 0.106118134128832 0.453228303242137 no 1504 0.457744311715066 2232 7185044
SGTC_1830 st055982 50.3 µM 0.105315185180099 0.453577985356635 no 1505 0.458062856975668 2232 455313 An antimicrobial agent.
SGTC_3297 9117502 71.43 µM 0.104063110975703 0.454123332040572 no 1506 0.45855963252442 2264 7453720
SGTC_2670 beta-carotene 100 µM 0.103928552055909 0.454181944963325 no 1507 0.458613024265258 2222 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.)
SGTC_2668 2',4'-dihydroxychalcone 15.08 µM 0.102736887961948 0.454701068896636 no 1508 0.459085898086542 2175 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_774 k060-0086 136 µM 0.102124778925163 0.454967751735517 no 1509 0.459328816549791 2232 5911235
SGTC_3036 9090181 49.47 µM 0.102093577297546 0.454981346163206 no 1510 0.459341199475754 2202 25236586
SGTC_1108 betulinic acid 729.144 nM 0.101770780090066 0.455121990741191 no 1511 0.45946930965428 2171 64945 Apoptosis-inducing agent of unknown mechanism.
SGTC_2013 4024628 200 µM 0.099470809168834 0.456124262945807 no 1512 0.460382231919985 2166 5230760
SGTC_1241 0364-0022 50.8 µM 0.0972511709529749 0.457091792954334 no 1513 0.461263466024974 2178 4563895
SGTC_3319 9138450 16.7555 µM 0.0970688937739498 0.457171258112766 no 1514 0.46133584167518 2099 2029690
SGTC_2236 dapsone 200 µM 0.0969416615906206 0.457226726990872 no 1515 0.46138636171505 2247 2955 A bacterial DFR inhibitor. An anti-cancer agent.
SGTC_1800 st050079 29.0735 µM 0.0968103276259608 0.457283984979289 no 1516 0.461438511101412 2206 3645560
SGTC_1370 2001-0092 44.6 µM 0.0965503515276998 0.457397330005721 no 1517 0.461541742970772 2201 790957
SGTC_949 1165-0505 146 µM 0.095458657082878 0.457873327389522 no 1518 0.461975263559765 2141 6244267
SGTC_99 0109-0120 622.8 µM 0.0953081073067253 0.457938974414326 no 1519 0.462035051635529 2223 759414
SGTC_278 4092-0821 23.9 µM 0.0945842505371519 0.458254627162605 no 1520 0.462322529998291 2189 877900
SGTC_2557 derrustone 83.84 µM 0.0928434226882571 0.459013858647565 no 1521 0.463013976826221 2061 629853 An antioxidant.
SGTC_1040 k898-0338 155 µM 0.0926682139108636 0.459090281205581 no 1522 0.46308357497167 2266 20969351
SGTC_2794 7785382 27.27 µM 0.0923701412391155 0.459220298004833 no 1523 0.46320198091115 2290 2205081
SGTC_2136 5328288 199.296 µM 0.0905840310901422 0.45999947516702 no 1524 0.463911560551906 2170 262395
SGTC_2503 beta-caryophyllene alcohol 24.72 µM 0.0904332997625416 0.460065237650503 no 1525 0.463971447855414 2105 61125 An anti-inflammatory.
SGTC_339 3091-4833 71.4 µM 0.0893992602533121 0.460516407507719 no 1526 0.464382305675586 2180 3240077
SGTC_1819 st053448 58.6 µM 0.0882965025677193 0.460997616330953 no 1527 0.464820509323523 2168 2857616
SGTC_2385 9074692 200 µM 0.0873147936639904 0.461426051345321 no 1528 0.46521064764371 2098 17046906
SGTC_545 4218-0007 221 µM 0.0846993101300193 0.462567711512319 no 1529 0.466250222217329 2186 2840508
SGTC_2728 chlorpromazine 9.18 µM 0.0815705868887815 0.463933805492194 no 1530 0.467494095794517 2274 2726 A thorazine and dopamine antagonist.
SGTC_417 st075190 100 µM 0.081540311506059 0.463947026731949 no 1531 0.467506133823876 2263 222757
SGTC_1773 st048542 73.5835 µM 0.0815319131580636 0.463950694292058 no 1532 0.46750947316132 2161 3237138
SGTC_690 glyoxal 20.3 µM 0.0796480498378264 0.464773454579456 no 1533 0.468258589166934 2196 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins.
SGTC_1000 4048-0884 8.67 µM 0.0788940729437871 0.465102789583199 no 1534 0.46855843882693 2193 13040088
SGTC_1994 st072947 40.9 µM 0.0781412277596693 0.465431654111071 no 1535 0.468857856213147 2172 5286565 YDL195W SEC31
SGTC_2142 5622915 118.518 µM 0.077964705147586 0.465508767713466 no 1536 0.468928064357075 2170 5322196
SGTC_1213 1315-0166 115 µM 0.0779151747411187 0.465530405219975 no 1537 0.468947764204733 2047 768401
SGTC_2125 5246583 200 µM 0.0778380641590829 0.465564091411636 no 1538 0.46897843373323 2262 835267
SGTC_814 3342-0569 96 µM 0.077636026385152 0.465652353919652 no 1539 0.469058791971808 2266 4346283
SGTC_1492 4158-0558 28.5 µM 0.0774318746201866 0.465741541665 no 1540 0.469139992306704 2243 3967268
SGTC_562 3772-2733 112 µM 0.0765334902184869 0.466134039085967 no 1541 0.469497335379172 2258 2876874 YIL048W NEO1
SGTC_49 0717-0965 32.132 µM 0.0762154498717838 0.466272996447714 no 1542 0.469623845610369 2219 5889349 YGL099W LSG1
SGTC_2871 9038510 12.99 µM 0.0759986974519208 0.466367701708654 no 1543 0.46971006724271 2286 4945164
SGTC_2835 9006588 71.43 µM 0.0757182105097085 0.466490257210409 no 1544 0.469821643846339 2118 2345538
SGTC_2853 9015042 58.44 µM 0.075287761618927 0.466678343014305 no 1545 0.469992879329706 2254 6457456
SGTC_3000 9075062 71.4286 µM 0.0752071752605192 0.466713556269228 no 1546 0.470024937746406 2175 17057871
SGTC_2412 st077135 33.4 µM 0.0751723971937856 0.466728753077235 no 1547 0.470038773023431 2223 13258915
SGTC_2498 4'-Methoxychalcone 54.63 µM 0.0751392551038627 0.466743235065297 no 1548 0.4700519575161 2246 641818 YHR062C RPP1
SGTC_1147 3809-1045 12.3 µM 0.0748426228496803 0.466872855426478 no 1549 0.470169964382532 2169 325925
SGTC_2565 isoliquiritigenin 100 µM 0.0743848150234796 0.467072912092346 no 1550 0.470352095591767 2046 638278 Binds to benzodiazepine receptor 65X better than valium.
SGTC_808 0711-0032 135 µM 0.0741453059007374 0.467177578095333 no 1551 0.470447382775834 2266 4252555
SGTC_1044 1222-0021 1.78 µM 0.0730659598634958 0.467649282695149 no 1552 0.470876814661737 2199 4306703
SGTC_874 0599-0792 117 µM 0.0721771111480701 0.468037768743628 no 1553 0.471230480156903 2278 765305
SGTC_1178 0988-0033 191 µM 0.0715744812683954 0.468301175449217 no 1554 0.471470274486699 2227 5392207
SGTC_17 0960-0276 49.807 µM 0.0715563284588635 0.468309110173369 no 1555 0.471477497888511 2294 6821114
SGTC_2346 9031566 143.75 µM 0.0712712753808165 0.468433710581546 no 1556 0.471590928001147 2233 4771086
SGTC_2320 7373003 200 µM 0.0705924713666169 0.468730437072309 no 1557 0.471861051222258 2214 5415828
SGTC_2122 5258151 111.688 µM 0.0701306823082164 0.468932309468618 no 1558 0.472044822933121 2221 2173356
SGTC_227 fluconazole 33.516 µM 0.0688977524484083 0.469471327244429 no 1559 0.47253550377814 2202 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C
SGTC_144 4161-2749 112.381 µM 0.0676544822928039 0.470014922294832 no 1560 0.473030342056142 2228 797501 YMR168C CEP3
SGTC_2003 4023581 200 µM 0.0674158054693875 0.470119285395592 no 1561 0.473125343434469 2215 16641307
SGTC_3065 9113888 49.47 µM 0.067178059739639 0.470223243409768 no 1562 0.473219975726012 2262 16648368
SGTC_1811 st050069 61.5 µM 0.0669845248462246 0.470307871047694 no 1563 0.473297011455942 2294 3877702
SGTC_2291 7917025 104.35 µM 0.0651290353574918 0.4711192945357 no 1564 0.474035631315695 2249 2964612
SGTC_2937 9044753 11.33 µM 0.0647450116966172 0.471287246882544 no 1565 0.474188511914953 2288 6465530 YGL099W LSG1
SGTC_1051 3253-3903 78 µM 0.0639895038912375 0.471617682309848 no 1566 0.474489292180764 2296 5509239
SGTC_2799 7812892 81.82 µM 0.063766810397789 0.471715085200538 no 1567 0.474577952959478 2268 20205235
SGTC_2177 5811945 192 µM 0.0631594639920566 0.471980738254647 no 1568 0.474819761674492 2253 5343475
SGTC_749 1000-0129 128 µM 0.0627084926443685 0.472178000997349 no 1569 0.47499931727685 2287 708470
SGTC_1820 st053765 18.6 µM 0.0624363849307278 0.472297028967424 no 1570 0.475107660242414 2223 3690829
SGTC_3243 9134147 49.47 µM 0.0612984413947709 0.472794825846124 no 1571 0.475560766028318 2306 24282180
SGTC_2321 7390090 138.78 µM 0.0611691070856235 0.472851406238829 no 1572 0.475612266309857 2208 649046
SGTC_709 3807-1509 243 µM 0.0607550716109617 0.47303253965659 no 1573 0.475777135921536 2296 1886677 YPL242C IQG1
SGTC_944 3370-0224 231 µM 0.0603209134481264 0.473222482394127 no 1574 0.475950022875032 2262 4580514
SGTC_2697 mebhydrolin 72.4 µM 0.059973769239063 0.473374361201764 no 1575 0.476088263094432 2276 22530 H1 Histamine receptor antagonist. YIL048W NEO1
SGTC_1867 st057372 64 µM 0.0599015588781773 0.47340595439069 no 1576 0.476117019160624 2293 688837
SGTC_1379 2144-0755 36.5 µM 0.0577155324910707 0.474362454200609 no 1577 0.476987610590783 2286 5392327
SGTC_3254 9136651 49.47 µM 0.0566415938059795 0.474832412504444 no 1578 0.477415350322891 2319 16454030
SGTC_2426 5582046 32.21 µM 0.0561578789643482 0.475044098829406 no 1579 0.477608017948047 2289 2251934
SGTC_655 k060-0012 42 µM 0.0553866850307126 0.475381608104344 no 1580 0.477915201680465 2250 5994525
SGTC_2381 9035592 200 µM 0.0533933236248606 0.476254074284024 no 1581 0.478709262301162 2156 4749657
SGTC_2689 tacrolimus 100 µM 0.0528267473110988 0.476502077708743 no 1582 0.478934974989032 2250 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12).
SGTC_2472 5377652 49.4 µM 0.0517653354250839 0.476966706416182 no 1583 0.479357838412426 2201 1610903
SGTC_1936 st074407 74.3 µM 0.0513585473397435 0.477144784569803 no 1584 0.479519907792891 2316 809813
SGTC_2091 4-phenylthiadiazole 200 µM 0.0504936413577153 0.477523426467438 no 1585 0.479864508202207 2290 270010
SGTC_780 0109-0199 192 µM 0.0504739927177191 0.477532028562327 no 1586 0.479872336892932 2314 610414
SGTC_1920 st075728 45.7 µM 0.049371811499815 0.478014575674324 no 1587 0.480311495960866 2318 3400306
SGTC_2828 7998861 71.43 µM 0.0493414510748368 0.478027868263155 no 1588 0.480323593274069 2310 2988188
SGTC_2695 st077686 51.995 µM 0.0490597025901092 0.478151226289377 no 1589 0.480435858694161 2272 2876092
SGTC_1307 1187-1599 12.2 µM 0.0488421691076929 0.478246470473867 no 1590 0.48052253808497 2258 1538471
SGTC_2375 9072683 200 µM 0.0483604206302746 0.478457402145806 no 1591 0.480714501068818 2331 16798029
SGTC_2254 7938975 95.19 µM 0.0482931106330351 0.478486874044577 no 1592 0.480741322533863 2309 2969277
SGTC_45 0kpi-0036 14.9 µM 0.0479382391619667 0.478642257600747 no 1593 0.480882731982471 2287 2795021
SGTC_2168 5727979 200 µM 0.046918745371573 0.479088669789996 no 1594 0.481288993950026 2314 695210
SGTC_2264 7948757 110.76 µM 0.0467558032926197 0.479160020713879 no 1595 0.481353927172442 2328 2971411
SGTC_1720 st037298 9.481 µM 0.0465236529593244 0.479261678485404 no 1596 0.481446441079759 2284 597396
SGTC_39 0986-0283 58.349 µM 0.0463490578185533 0.479338133940363 no 1597 0.481516019405729 2309 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2
SGTC_3292 9120825 59.784 µM 0.0463208104812395 0.47935050356018 no 1598 0.481527276372466 2332 24824900
SGTC_1258 0671-0043 57.1 µM 0.0455377249337837 0.479693427668823 no 1599 0.481839352962485 2282 4298767
SGTC_2220 6782180 200 µM 0.0445769959141553 0.480114164843367 no 1600 0.482222239514806 2319 833803
SGTC_3018 9082602 49.47 µM 0.0444816695140891 0.480155912857184 no 1601 0.482260231561056 2277 17332089
SGTC_1380 2291-0730 164 µM 0.0437827443307717 0.480462012417986 no 1602 0.482538790961385 2270 2999191
SGTC_163 TUB2.036 7.546 µM 0.0436997658516692 0.480498354238008 no 1603 0.482571862931657 2334 15992207 YJR013W GPI14
SGTC_1260 0700-1617 7.75 µM 0.0417005968300935 0.481373972216645 no 1604 0.483368689087482 2281 2853078
SGTC_831 k061-1017 217 µM 0.0414502364555241 0.481483634218487 no 1605 0.483468482141785 2311 1240153
SGTC_3136 9095672 49.47 µM 0.0408139858672372 0.481762328828223 no 1606 0.483722094770008 2353 17217380
SGTC_1873 rapamycin 2 nM 0.0406385555786338 0.481839173514523 no 1607 0.483792023312493 2318 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1
SGTC_579 4491-1009 110 µM 0.0403154434685477 0.481980709838497 no 1608 0.483920820840598 2350 1271041
SGTC_1592 4',5'-dihydroxyflavone 8.85 µM 0.0392704908584979 0.482438457293449 no 1609 0.48433736667219 2325 688669
SGTC_1058 3448-5425 97.3 µM 0.0390130205723869 0.482551247200004 no 1610 0.484440003800867 2337 7279705
SGTC_2247 cerulenin 830 nM 0.0388156006822075 0.482637731799731 no 1611 0.484518703331082 2327 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12
SGTC_568 1193-0097 7.48 µM 0.0383190487037544 0.48285526211185 no 1612 0.484716651634946 2337 3646150
SGTC_2052 5265182 7.135 µM 0.0359595236084195 0.483888995411105 no 1613 0.485657316773115 2332 1239884
SGTC_1916 st067606 49.2 µM 0.0357544210968302 0.483978858241508 no 1614 0.485739088252047 2314 19590279
SGTC_114 0364-0001 490.298 µM 0.0357033227395112 0.484001246407258 no 1615 0.485759460539942 2235 4003655
SGTC_1303 1160-0052 261 µM 0.0349562270798846 0.484328583620956 no 1616 0.486057322626444 2341 3562476
SGTC_318 1488-0629 67.2 µM 0.0344694542713763 0.484541867031959 no 1617 0.486251399913809 2274 3662576
SGTC_2785 7756463 72.73 µM 0.0343317004271824 0.484602225789428 no 1618 0.486306323238762 2328 2201551
SGTC_289 k017-0060 526 µM 0.0334370708497984 0.484994228671783 no 1619 0.486663023958551 2342 5512909
SGTC_3280 9140961 49.47 µM 0.0327344442300522 0.485302111152406 no 1620 0.48694317803901 2327 4901226
SGTC_98 0074-0023 107.663 µM 0.0325373576670143 0.485388473680408 no 1621 0.487021762340483 2270 3563821
SGTC_1669 st015249 58.4 µM 0.0320970062838051 0.485581436330656 no 1622 0.487197345410615 2349 722793
SGTC_1148 3909-7663 27.7 µM 0.031882969615917 0.485675228748335 no 1623 0.48728269000656 2347 4084526
SGTC_139 0099-0334 718.624 µM 0.0305428627789636 0.486262491074903 no 1624 0.487817054879243 2356 97690
SGTC_1665 st014639 11.4 µM 0.0294237032130103 0.486752952655188 no 1625 0.488263334278268 2349 981133 YIL048W NEO1
SGTC_1045 1348-1485 165 µM 0.0286225913702203 0.48710404503922 no 1626 0.488582797078171 2353 6810614
SGTC_2371 9071574 200 µM 0.0279641247158584 0.487392629754078 no 1627 0.488845382139528 2360 45596039
SGTC_663 1486-0733 13.9 µM 0.0278457471020022 0.487444511551866 no 1628 0.488892589591265 2320 722445 YPR165W RHO1
SGTC_2461 5755302 26.15 µM 0.027369443958607 0.487653264843326 no 1629 0.489082534651764 2352 2788904
SGTC_2687 chenodiol 100 µM 0.0251273297601241 0.488635979145293 no 1630 0.48997670053251 2338 5702181 A cholesterol synthesis inhibitor.
SGTC_2767 sibutramine 71.45 µM 0.0248282984667693 0.488767049325793 no 1631 0.490095959550019 2366 64765 A serotonin-norepinephrine reuptake inhibitor.
SGTC_3289 9119912 71.43 µM 0.022257723337601 0.489893821924021 no 1632 0.491121186204511 2348 17014829
SGTC_2309 7664088 163.95 µM 0.0218385996791365 0.490077546304894 no 1633 0.491288351715059 2370 704922
SGTC_3020 9089140 49.47 µM 0.0213086951402684 0.490309834896463 no 1634 0.491499703848001 2352 17217859
SGTC_2720 fluspirilene 36.88 µM 0.0208299888730895 0.490519683076423 no 1635 0.491690637631952 2356 3396 An atypical antipsychotic.
SGTC_1002 4049-0206 172 µM 0.0207837639384195 0.49053994662011 no 1636 0.491709074721419 2367 4662749
SGTC_2867 9039098 71.43 µM 0.0206794682030151 0.490585666648665 no 1637 0.491750673759326 2379 6463460
SGTC_1506 4226-2149 212 µM 0.0196450690885769 0.491039121866649 no 1638 0.492163255413228 2297 991114
SGTC_3192 9110362 49.47 µM 0.0192188373391715 0.491225974821054 no 1639 0.492333265177087 2382 16649480
SGTC_475 α-linolenic acid 10 µM 0.0185150057071019 0.491534527171277 no 1640 0.492614003397272 2369 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_1359 1582-0056 520 nM 0.0183787492442398 0.491594261155777 no 1641 0.492668352613283 2357 3661189
SGTC_3307 9126885 69.2785 µM 0.0161986188167292 0.49255004148084 no 1642 0.493537968672192 2370 24824909
SGTC_3277 9138724 49.47 µM 0.0157923112102121 0.49272817370583 no 1643 0.493700041219312 2302 15943418
SGTC_938 3126-1755 342 µM 0.0155992585945153 0.492812811794784 no 1644 0.493777048583675 2370 1777771
SGTC_653 0203-0016 55.2 µM 0.0155504511550095 0.492834209993991 no 1645 0.493796517573391 2366 295302
SGTC_1392 3455-1037 33.9 µM 0.0146986661573501 0.493207653564019 no 1646 0.494136291748218 2364 981132
SGTC_2276 7947513 42.08 µM 0.014609516795555 0.49324673919474 no 1647 0.494171853379397 2341 2105100
SGTC_264 promethazine 12.5 mM 0.0142805600175722 0.493390963815563 no 1648 0.494303074455015 2382 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3
SGTC_3203 9113543 49.47 µM 0.0136398011760225 0.493671894373753 no 1649 0.494558675336266 2352 17018012
SGTC_3022 9087993 49.47 µM 0.0132669409089155 0.493835370501593 no 1650 0.494707411599901 2383 17173644
SGTC_792 4534-1957 155 µM 0.0127187908809418 0.494075702202073 no 1651 0.494926073361901 2319 1717904
SGTC_1411 3909-8223 150 µM 0.0121913544593505 0.49430695422968 no 1652 0.495136473728044 2373 X1411
SGTC_1523 st012844 44.7 µM 0.0120586003266551 0.494365159961533 no 1653 0.495189431071528 2322 4274103
SGTC_358 0075-0058 9.45 µM 0.0112536202536762 0.494718104072906 no 1654 0.495510549833725 2387 1069125
SGTC_1728 st035614 33.7865 µM 0.0111556654105914 0.494761052734366 no 1655 0.495549625709237 2328 15945546
SGTC_2308 7584454 197.62 µM 0.0109841500135525 0.49483625443739 no 1656 0.495618046260419 2377 893577
SGTC_3064 1327-0027 10 µM 0.00981369833238222 0.495349449041213 no 1657 0.496084963650202 2372 16000455 YPR107C YTH1
SGTC_2620 irigenin 100 µM 0.0094335550651975 0.495516127822303 no 1658 0.496236611848629 2381 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro.
SGTC_1332 1480-0653 17.5 µM 0.00937785063111886 0.49554055222551 no 1659 0.49625883371961 2393 5749438
SGTC_3109 9122853 49.47 µM 0.00914939365472879 0.495640722617417 no 1660 0.496349970956006 2343 1234709
SGTC_59 0330-0160 1.33 µM 0.00846939359188261 0.495938880458133 no 1661 0.4966212412003 2355 4293482
SGTC_2640 pentamidine 10.38 µM 0.0084464143718132 0.495948956136937 no 1662 0.496630408254863 2388 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_2769 toremifene 3.73 µM 0.00694779773429096 0.496606058564137 no 1663 0.497228252027719 2385 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_1981 st071826 47 µM 0.00651198472058435 0.496797152464033 no 1664 0.497402112326624 2356 11838600
SGTC_1016 4226-1401 38 µM 0.00639956160122783 0.49684644751575 no 1665 0.497446961727602 2386 2901613
SGTC_1927 st060202 13.8 µM 0.00597016783381846 0.497034727623823 no 1666 0.497618261778683 2394 688887
SGTC_3220 9131269 49.47 µM 0.00591231683366252 0.497060094118319 no 1667 0.49764134058128 2402 17722206
SGTC_1389 3405-0187 19 µM 0.00537356696542829 0.497296325605438 no 1668 0.49785626725772 2393 799890
SGTC_2256 7954252 200 µM 0.00498236113539893 0.497467862459722 no 1669 0.498012333710476 2364 2972920
SGTC_1784 st039334 36.3 µM 0.00346017668064128 0.498135317650646 no 1670 0.498619591978997 2397 3496984
SGTC_862 0452-0056 10.2 µM 0.00301181922911142 0.498331916788001 no 1671 0.498798459785121 2399 1575396 YLR359W | YHR072W ADE13 | ERG7
SGTC_1011 4112-3381 17.4 µM 0.00293291135447751 0.49836651694784 no 1672 0.498829939333501 2384 2877139
SGTC_50 0929-0078 56.389 µM 0.0028202396732493 0.498415922154524 no 1673 0.498874888644952 2387 1377751
SGTC_2810 7959871 45.46 µM 0.00217279114378975 0.498699821165409 no 1674 0.499133182428305 2400 2974535
SGTC_3074 9116018 49.47 µM 0.000442109525346449 0.499458708729821 no 1675 0.499823623823517 2401 17027303
SGTC_3308 9128332 17.569 µM -7.09642963445579e-05 0.499683687261045 no 1676 0.499971689341813 2406 17332805 YDL196W YDL196W
SGTC_1576 erythromycin ethylsuccinate 23.2 µM -0.00019145331462977 0.499736520693697 no 1677 0.499923621178538 2406 3256 An antibiotic and ribosome inhibitor.
SGTC_182 3448-4371 550.524 µM -0.000602460334996756 0.499916743883767 no 1678 0.499759653114644 2402 3491403
SGTC_2679 rapamycin 1 nM -0.00098219886890154 0.499916743883767 no 1679 0.499608159406435 2409 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2
SGTC_439 amiodarone 34.4 µM -0.00166858405797759 0.499615769664767 no 1680 0.499334331579758 2405 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1
SGTC_842 0271-0008 11.1 µM -0.00206207034215574 0.499443229276654 no 1681 0.499177353538353 2413 1221709
SGTC_2808 7946468 45.46 µM -0.00324382320737591 0.498925041454384 no 1682 0.498705904041928 2411 2970879
SGTC_3161 9100388 49.47 µM -0.00374379106609837 0.498705810616733 no 1683 0.498506446943678 2410 25236368
SGTC_2702 st077768 96.8 µM -0.00433407699769651 0.498446976727957 no 1684 0.498270958852221 2415 6484119
SGTC_2303 7774051 200 µM -0.00514929794027125 0.498089512408432 no 1685 0.497945736415471 2427 2953184
SGTC_2985 9022375 71.43 µM -0.00526306601467813 0.498039626627679 no 1686 0.497900350135541 2455 4939335
SGTC_1979 st071809 45.3 µM -0.00599777991434767 0.497717465170383 no 1687 0.497607246349532 2426 4976333
SGTC_3351 9150312 21.596 µM -0.00669233577863428 0.497412913798075 no 1688 0.497330164232423 2419 4904905
SGTC_3010 9080089 71.4286 µM -0.00780539117798444 0.496924860451529 no 1689 0.496886131062355 2414 17027233
SGTC_1427 4048-4900 550 nM -0.00798282690696996 0.496847058709571 no 1690 0.496815346653671 2429 24132586
SGTC_1600 coumarin 106 71.1 µM -0.00811482051937632 0.496789182433701 no 1691 0.496762690526631 2483 100336 A hepatotoxic, DNA x-linker.
SGTC_2017 5132927 60.65 µM -0.0097099253386201 0.496089769994981 no 1692 0.496126361112469 2426 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis
SGTC_2450 5739737 12.93 µM -0.0104428316254245 0.495768413337879 no 1693 0.495833988656796 2427 2262825
SGTC_612 0302-0167 22.4 µM -0.0117321497851032 0.495203094138016 no 1694 0.495319656780644 2430 235821
SGTC_3343 9148379 18.9835 µM -0.0117912824554721 0.495177166831451 no 1695 0.49529606788996 2423 1955036
SGTC_815 1582-0027 36.9 µM -0.0120106881513442 0.495080966404086 no 1696 0.495208543879875 2440 3128206
SGTC_2250 alverine citrate 130 µM -0.0123565132993999 0.494929336798487 no 1697 0.495070589846713 2422 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1
SGTC_1079 idarubicin 2.36 µM -0.0124206329526287 0.494901223139982 no 1698 0.495045011768936 2423 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_902 1120-0002 2.07 µM -0.0125537092518062 0.494842875094577 no 1699 0.494991926145681 2439 3280475
SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM -0.0137182857927216 0.494332264861573 no 1700 0.494527367433557 2427 5711223 A potent inhibitor of glutathione S-transferases.
SGTC_1605 st000082 49.1 µM -0.0143241477235462 0.494066627459455 no 1701 0.494285687254628 2493 1114022
SGTC_2233 sulbentine 40.3845 µM -0.014355442082016 0.494052906661068 no 1702 0.494273203895438 2420 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58
SGTC_2446 5162541 200 µM -0.0143714156570324 0.494045903158577 no 1703 0.494266832018314 2434 1549321
SGTC_533 1222-0222 6.71 µM -0.01490789952444 0.493810686630398 no 1704 0.49405282885718 2512 3982874
SGTC_397 arbidol 50 µM -0.0151582959816616 0.493700903286626 no 1705 0.493952946410848 2447 131410 A RNA synthesis inhibitor.
SGTC_1112 tnp00069 1.16933 µM -0.0160089425830081 0.493327951030806 no 1706 0.493613628730134 2505 145826
SGTC_1250 0485-0349 40.2 µM -0.0162181636492319 0.493236222316414 no 1707 0.493530172436293 2448 6842794 YDL195W SEC31
SGTC_1071 trifluoperazine 6.31 µM -0.0165798980674492 0.493077628076254 no 1708 0.493385880686742 2462 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels.
SGTC_3125 9127534 49.47 µM -0.0171595569215101 0.492823492108608 no 1709 0.493154663168057 2436 1639235
SGTC_3232 9132874 49.47 µM -0.0181462819434708 0.492390895589169 no 1710 0.492761078183981 2441 3784940
SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM -0.0183510082866379 0.492301141288816 no 1711 0.492679417788043 2445 4330530
SGTC_204 PMA1.184 62.41 µM -0.0210387443406473 0.491122845833945 no 1712 0.491607374496768 2432 2252213 YGL008C PMA1
SGTC_528 3492-0019 172 µM -0.0213184797139866 0.491000214956288 no 1713 0.491495801254363 2439 2869262
SGTC_3174 9107204 49.47 µM -0.0216725805609562 0.490844984834853 no 1714 0.491354568088432 2459 3938802
SGTC_1948 st076329 66.6 µM -0.0219408970181422 0.490727361649076 no 1715 0.491247550757661 2435 24208413
SGTC_2407 paclitaxel 400 µM -0.0231357968483982 0.490203557553367 no 1716 0.490770975782828 2627 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_1454 4239-0054 42.6 µM -0.0234284085325609 0.490075288924431 no 1717 0.490654272244924 2513 1340767
SGTC_106 0092-0003 11.579 µM -0.0240223433185192 0.489814936118276 no 1718 0.490417393228692 2491 1072148
SGTC_1270 0831-1170 17.3 µM -0.0240701874275638 0.489793963720218 no 1719 0.490398311708211 2447 6764716
SGTC_2420 aureobasidin a 50 nM -0.0244367845985187 0.48963326730552 no 1720 0.490252103606096 2470 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1
SGTC_3013 9080133 71.4286 µM -0.0249993073344457 0.489386690978283 no 1721 0.490027758051999 2477 17050193
SGTC_234 nsc-17383 10.7 µM -0.0252610807521397 0.489271946543938 no 1722 0.489923358538837 2454 408974
SGTC_3227 9130768 49.47 µM -0.0264714951866554 0.488741391303886 no 1723 0.489440634587388 2462 17720899
SGTC_1054 3429-0080 167 µM -0.0281535115930515 0.488004154279767 no 1724 0.488769857443022 2463 1162877
SGTC_1309 pyrazolanthrone 13.4 µM -0.028373864531994 0.487907575359597 no 1725 0.488681984444315 2455 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14
SGTC_1495 4469-0029 237 µM -0.0294346880532683 0.487442634970788 no 1726 0.488258953858348 2446 793680
SGTC_2411 st077133 39.94 µM -0.029799349563843 0.487282814120725 no 1727 0.488113538755261 2628 1403142 YNL221C POP1
SGTC_111 0083-0039 52.457 µM -0.0300019150595196 0.487194036260669 no 1728 0.488032762931419 2451 759313
SGTC_73 0327-0325 16.231 µM -0.0301483563682365 0.487129856198994 no 1729 0.487974367717438 2483 53298
SGTC_3346 9158254 43.5805 µM -0.0309082079022307 0.486796845455231 no 1730 0.487671372046236 2484 17639500
SGTC_3354 9151612 71.43 µM -0.0309665867639429 0.486771260850654 no 1731 0.487648093392949 2469 27261949
SGTC_2397 5161689 200 µM -0.03127327975595 0.486636853184219 no 1732 0.487525799823772 2477 2259942
SGTC_2288 7946289 167.31 µM -0.0321055041374886 0.486272139998998 no 1733 0.487193957003798 2473 1246052
SGTC_2904 7225135 42.03 µM -0.032473705006393 0.486110783662087 no 1734 0.487047142665971 2473 4446116
SGTC_1698 5-fluorocytosine 1.055 µM -0.0336117414038685 0.485612077483029 no 1735 0.486593379636611 2469 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_369 0957-0393 4.5 µM -0.0340054024456866 0.485439573968861 no 1736 0.486436421332738 2473 6997992
SGTC_151 3013-0144 2.285 µM -0.0365335956024134 0.484331778058562 no 1737 0.485428445582232 2553 906558 YHR107C CDC12
SGTC_542 3381-0244 89.3 µM -0.0371931756625361 0.484042784837574 no 1738 0.485165489940835 2474 1112843
SGTC_2906 7926292 26.41 µM -0.0372323586804121 0.484025617166448 no 1739 0.48514986899794 2514 2966319
SGTC_1735 st034310 56.75 µM -0.0378060469568407 0.483774264445818 no 1740 0.484921161523179 2647 871153
SGTC_634 1611-4317 11.2 µM -0.0399659523094003 0.482827993700247 no 1741 0.484060135357634 2475 2843522
SGTC_3180 9109287 49.47 µM -0.0407513829144588 0.482483914358391 no 1742 0.483747048973856 2530 18891271
SGTC_1908 st060353 56.5 µM -0.0417103738744697 0.48206381987404 no 1743 0.483364792001771 2499 4227716
SGTC_1020 4335-0961 93.3 µM -0.0421505860942126 0.481870987652727 no 1744 0.48318932705238 2472 669075
SGTC_2059 5238311 157 µM -0.0426140955075612 0.481667954825665 no 1745 0.483004579553748 2493 703021
SGTC_1368 1852-0141 284 µM -0.042692984823977 0.481633399104297 no 1746 0.482973135886097 2509 2838987
SGTC_992 3909-8734 162 µM -0.0429674319865466 0.481513184667581 no 1747 0.482863747687901 2508 4288319
SGTC_1362 1611-0397 101 µM -0.0438668811842489 0.481119216196251 no 1748 0.482505257431157 2493 27816
SGTC_2001 4023502 57.655 µM -0.0450778210998775 0.48058884061756 no 1749 0.482022639823445 2532 108941 YCR052W RSC6
SGTC_2733 amorolfine 100 µM -0.0455572022664124 0.48037888748339 no 1750 0.481831590686865 2508 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_2935 9038016 29.96 µM -0.0472479218621885 0.479638451926005 no 1751 0.481157817010572 2490 6463195
SGTC_1963 st076565 50.3 µM -0.0515809180592224 0.477741181721351 no 1752 0.479431312139755 2500 4914280
SGTC_1047 2043-3044 82 µM -0.0526401237788816 0.477277466988096 no 1753 0.479009323559725 2497 669592
SGTC_97 0535-0701 19.132 µM -0.0527882377396358 0.477212625906922 no 1754 0.47895031667921 2513 2832013 YGL099W LSG1
SGTC_65 0798-0905 34.986 µM -0.0528308683906256 0.477193963243806 no 1755 0.478933333208776 2541 3602145
SGTC_472 calcifediol 10 µM -0.0536279313976486 0.476845037681681 no 1756 0.47861580124493 2560 5283731 A vitamin D metabolite.
SGTC_643 k048-0106 28.4 µM -0.0542846659235603 0.476557556216625 no 1757 0.478354183179548 2585 6763920
SGTC_551 k048-0028 34.9 µM -0.0546849665580849 0.476382333072175 no 1758 0.478194723194444 2535 6836383
SGTC_1029 k015-0030 64.7 µM -0.0548930241742662 0.476291262048411 no 1759 0.478111844701877 2623 2208316
SGTC_2081 5214970 32.255 µM -0.0551806318471787 0.476165372397177 no 1760 0.477997279484864 2501 2063512
SGTC_2617 dihydrotanshinone i 20.83 µM -0.0556074747249219 0.475978542059394 no 1761 0.477827254875702 2534 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12
SGTC_77 0828-0286 12.516 µM -0.0570980733167714 0.475326144518363 no 1762 0.477233535595917 2501 745345
SGTC_274 sirtinol 40.1 µM -0.0574242999989581 0.475183372060334 no 1763 0.477103603168725 2529 6836442 NAD-dependent acetyltransferase inhibitor.
SGTC_2210 7115885 190.385 µM -0.0583565080211869 0.474775410700555 no 1764 0.476732328635436 2514 2927039
SGTC_1790 st045711 43.5 µM -0.0592935218374884 0.474365372837817 no 1765 0.476359160431633 2513 585119
SGTC_262 fenpropimorph 62.5 µM -0.0621992879851786 0.473093982253859 no 1766 0.475202064749686 2515 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_2453 5731132 22.18 µM -0.0632017389137533 0.47265543222427 no 1767 0.47480293004852 2551 1362040
SGTC_1264 0783-0040 158 µM -0.0632315870913155 0.47264237481465 no 1768 0.474791046118389 2517 2855798
SGTC_246 cycloheximide 667 µM -0.0635648860912845 0.472496571545572 no 1769 0.474658346007245 2512 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells.
SGTC_907 3448-6986 75.5 µM -0.0635926714073736 0.472484416890017 no 1770 0.474647283650959 2559 590582
SGTC_696 1560-0013 611 µM -0.0642925309189184 0.472178272607405 no 1771 0.474368650307757 2609 1650269
SGTC_2724 maprotiline 69.64 µM -0.0643170671122382 0.472167539871473 no 1772 0.474358882000234 2505 4011 A tricyclic antidepressant.
SGTC_1861 st057647 17.4 µM -0.065343083949319 0.471718752995842 no 1773 0.473950419794753 2619 688668
SGTC_2709 st078560 56 µM -0.0654908127275471 0.471654138348231 no 1774 0.473891610507418 2544 17250903
SGTC_2056 5235370 200 µM -0.06657349494606 0.471180610097239 no 1775 0.473460623444855 2571 5511916
SGTC_619 1652-1634 108 µM -0.0670820970452425 0.470958178921255 no 1776 0.473258173137782 2565 5400454
SGTC_1280 0880-0253 10.1 µM -0.0674894708843475 0.47078002527124 no 1777 0.473096021966041 2556 6836607
SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM -0.0677341376882624 0.470673029838874 no 1778 0.472998636879125 2562 6728940
SGTC_449 xestospongin c 11.1929 µM -0.0679855760908252 0.470563075319231 no 1779 0.47289855816442 2588 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1
SGTC_2454 5-benzylidenerhodanine 10.36 µM -0.0682741148023979 0.470436899525653 no 1780 0.472783714715799 2552 1273210
SGTC_1685 st024049 53.0905 µM -0.0692792029854132 0.469997405331992 no 1781 0.472383689785291 2590 1941139
SGTC_658 3253-0951 102 µM -0.0696366075366253 0.469841132079493 no 1782 0.472241449525517 2569 1184878
SGTC_512 prima-1 270 µM -0.0702203116758516 0.46958592052644 no 1783 0.472009153924842 2662 322968 A re-activator of the apoptotic function of mutant p53.
SGTC_2398 5228213 48.84 µM -0.0707633284112124 0.469348509845148 no 1784 0.471793059158211 2537 80771 YMR134W ERG29
SGTC_537 1334-0398 209 µM -0.0709985436263971 0.46924567549999 no 1785 0.471699457292575 2519 5846986
SGTC_1326 1431-2094 10.8 µM -0.0710971990695189 0.469202544683251 no 1786 0.471660198675108 2533 616278
SGTC_3210 9128157 49.47 µM -0.071339189954415 0.469096751094098 no 1787 0.471563902797654 2673 17590849
SGTC_581 0958-0271 211 µM -0.07143301983313 0.469055731128871 no 1788 0.47152656534856 2509 4591145
SGTC_2232 chlorophetanol 41.5365 µM -0.0719841021872809 0.468814819002464 no 1789 0.471307279821668 2550 15907 An antifungal of unknown mechanism. YFR051C RET2
SGTC_2191 5911152 200 µM -0.0723157387210938 0.468669845692566 no 1790 0.471175319900593 2541 2875902
SGTC_3123 9126162 49.47 µM -0.0731208072085854 0.468317931210417 no 1791 0.470854992109796 2542 25239884
SGTC_1537 2',6'-dihydroxyflavanone 78 µM -0.0733380536179052 0.468222971895275 no 1792 0.470768555403564 2543 5106787 A p450 inhibitor.
SGTC_2463 5473429 200 µM -0.0733506118501357 0.468217482694611 no 1793 0.470763558851056 2618 5399405
SGTC_2581 avocatin a 64 µM -0.0739552710919728 0.467953193436355 no 1794 0.470522988122372 2581 6710728 A skin care supplement.
SGTC_857 0438-0306 1.35 µM -0.0743905198303405 0.467762960201067 no 1795 0.47034982599125 2599 4686136
SGTC_1113 artemisinin 1.17947 µM -0.0750356070878828 0.467481026846951 no 1796 0.470093190689103 2532 2240 An anti-malaria and mitochondrial poison.
SGTC_1458 k015-0034 6.33 µM -0.076178151631442 0.466981721472611 no 1797 0.469638682322226 2578 3598957
SGTC_100 0086-0128 49.5915 µM -0.0790024678417952 0.465747686731601 no 1798 0.468515330073463 2554 93297
SGTC_1798 st045719 60.953 µM -0.0790463188451506 0.465728529380815 no 1799 0.468497890592802 2540 3980186
SGTC_1405 3909-7894 12 µM -0.0791307245097763 0.465691654988053 no 1800 0.468464322752151 2617 7104060
SGTC_2242 6630449 61.2675 µM -0.0794648857290619 0.465545672514178 no 1801 0.468331430195075 2731 691249 YDR170C SEC7
SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM -0.0810674720790432 0.464845627566925 no 1802 0.467694147019381 2527 4000243
SGTC_1031 k035-0009 16 µM -0.0813161071298402 0.464737028005291 no 1803 0.467595282386209 2657 5180959
SGTC_2780 5215298 71.43 µM -0.0816467077501419 0.464592631346593 no 1804 0.467463828920761 2570 2834131
SGTC_1755 st041960 45.185 µM -0.0830990875225423 0.463958329934467 no 1805 0.466886375694982 2640 2257073
SGTC_1469 k284-2957 126 µM -0.0831388128180685 0.463940981887485 no 1806 0.466870582245908 2591 23884841
SGTC_2332 7982454 138.89 µM -0.0839598332994982 0.463582457426664 no 1807 0.466544183673188 2525 2981748
SGTC_1794 st048918 76.9 µM -0.084016795674981 0.463557584104488 no 1808 0.466521538982476 2533 672303
SGTC_2593 nobiletin 86.24 µM -0.084787902941446 0.463220884684702 no 1809 0.466215005480552 2628 72344 An anti-infammatory.
SGTC_67 0335-0847 266 µM -0.0863587375546211 0.46253507081094 no 1810 0.465590623502121 2893 4552207 YOR254C SEC63
SGTC_1851 st056236 18.9 µM -0.0864797723893108 0.462482232561356 no 1811 0.465542517559507 2560 5393171
SGTC_1721 st082152 9.2685 µM -0.0878000416728614 0.461905906829656 no 1812 0.465017802322108 2567 5296051
SGTC_1301 naphtanilide LB 4.81 µM -0.0879851124167687 0.461825125862043 no 1813 0.464944254409629 2615 67238 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_2370 9071495 200 µM -0.088319419271536 0.461679209270967 no 1814 0.46481140245977 2620 21791103
SGTC_2329 6138490 200 µM -0.08873855234463 0.461496275444211 no 1815 0.464644846518724 2816 720019
SGTC_3152 9099253 49.47 µM -0.0888650469763919 0.461441067495823 no 1816 0.464594581043865 2624 25236131
SGTC_3049 9092223 49.47 µM -0.0900539264888604 0.460922223442777 no 1817 0.464122180864097 2661 8623917
SGTC_2611 pyromycin 23.93 µM -0.0907086009393638 0.460636542474687 no 1818 0.463862068124046 2602 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release.
SGTC_53 0973-0023 39.979 µM -0.0910994279286852 0.460466006571285 no 1819 0.463706793600487 2557 674768
SGTC_660 4031-1742 102 µM -0.0918469421858856 0.460139851785278 no 1820 0.463409823592595 2567 6738706
SGTC_1186 1319-0216 26 µM -0.0919912682890816 0.460076882624546 no 1821 0.463352488535705 2700 4565136
SGTC_3320 9137005 35.139 µM -0.0926635180297159 0.459783594763324 no 1822 0.4630854403311 2626 4908713
SGTC_2322 7413319 38.22 µM -0.0935386756093839 0.459401815459106 no 1823 0.462737812836297 2672 1840400
SGTC_2186 6124449 200 µM -0.0936377674312632 0.459358589931918 no 1824 0.462698453665579 2647 3834182 YLR033W RSC58
SGTC_865 0488-0499 301 µM -0.0942499029238327 0.459091576756391 no 1825 0.462455322182331 2559 9634651
SGTC_2825 7998094 58.44 µM -0.0945258545601822 0.458971212827132 no 1826 0.462345722711363 2642 2987815
SGTC_717 1532-0246 73.2 µM -0.0953474909359608 0.45861285573837 no 1827 0.462019411068329 2626 9561992
SGTC_2082 5219693 150 µM -0.0965319497702624 0.458096312729486 no 1828 0.461549050078551 2570 2834649
SGTC_541 4513-1321 94 µM -0.0966592557505639 0.458040798732595 no 1829 0.461498498731482 2588 747515
SGTC_1662 st014054 52 µM -0.096957883317221 0.457910580178594 no 1830 0.461379920524897 2561 2838777
SGTC_2123 5259487 200 µM -0.096978628754243 0.457901534159257 no 1831 0.461371683111674 2639 2173474
SGTC_308 4092-1169 104 µM -0.0978293103491065 0.457530614451904 no 1832 0.461033916359565 2598 2268590 YDL196W YDL196W
SGTC_1821 st053465 65.6 µM -0.0980015299803065 0.457455526622875 no 1833 0.46096553923458 2648 675086
SGTC_2512 diallyl trisulfide 49.23 µM -0.0986537334284022 0.457171179443092 no 1834 0.460706602480828 2555 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent
SGTC_1895 st058434 18.3 µM -0.0989395553369091 0.457046573918492 no 1835 0.460593131174839 2586 5393175
SGTC_839 0122-0028 230 µM -0.0998223538841654 0.456661740088459 no 1836 0.460242680427188 2587 759448
SGTC_2932 9016711 44.54 µM -0.100142036628678 0.456522392438808 no 1837 0.460115781321984 2606 7117328
SGTC_616 4092-0450 108 µM -0.100618750509745 0.456314605864279 no 1838 0.459926555746097 2635 787165
SGTC_1263 0774-1208 64.8 µM -0.101448465910113 0.455952984080853 no 1839 0.459597232330423 2607 906585
SGTC_341 1486-1430 230 µM -0.101724770242677 0.455832568142138 no 1840 0.459487570160708 2587 2054753 YPL210C SRP72
SGTC_1826 st055655 41.6 µM -0.101803273047377 0.455798356646137 no 1841 0.459456413817422 2625 676168
SGTC_3069 9117009 49.47 µM -0.10241037963729 0.455533790884585 no 1842 0.459215472615951 2591 41904981
SGTC_510 ag-490 170 µM -0.102583501415808 0.455458351240979 no 1843 0.45914676885632 2588 5328779
SGTC_24 0417-1663 219 µM -0.102735477097038 0.455392127556308 no 1844 0.459086457977648 2644 4329390
SGTC_196 k015-0023 18.111 µM -0.102971271679412 0.455289382084264 no 1845 0.458992885802192 2588 5211998
SGTC_3313 9133968 57.047 µM -0.103234307460101 0.455174770022192 no 1846 0.458888505973762 2574 1494643
SGTC_2092 5303694 80.6725 µM -0.103836697020465 0.454912306078301 no 1847 0.45864947192673 2623 1963699
SGTC_2368 9071271 200 µM -0.105339845912759 0.454257463164683 no 1848 0.458053073187652 2616 27209959
SGTC_650 1328-0195 38 µM -0.105891850482143 0.454017014921428 no 1849 0.457834080043375 2578 2780821
SGTC_2768 sulfasalazine 50.2 µM -0.107909262482841 0.453138392331192 no 1850 0.45703383481524 2615 5384001 An antioxidant and salicylic acid derivative.
SGTC_2678 equilin 100 µM -0.107960467767752 0.453116094389404 no 1851 0.457013525508385 2640 3247 Equilin is an estrone commonly used hormone replacement therapy
SGTC_710 3448-4187 58 µM -0.108297905133432 0.452969157031551 no 1852 0.456879692152725 2613 3946412
SGTC_2946 9065502 71.43 µM -0.109057229655681 0.452638532169498 no 1853 0.456578549136824 2581 16489101
SGTC_57 miconazole 162.5 nM -0.112242702460514 0.4512518749681 no 1854 0.455315485702734 2569 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_3276 9139060 49.47 µM -0.112743818575064 0.451033789536868 no 1855 0.455116830250278 2596 4870619
SGTC_2352 9027995 87.8 µM -0.113021500521184 0.450912948881266 no 1856 0.455006754739023 2657 2997347
SGTC_237 nikkomycin 200 µM -0.113043946154874 0.45090318126769 no 1857 0.45499785724761 2707 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine.
SGTC_2972 9093619 59.92 µM -0.113066608230309 0.450893319495832 no 1858 0.454988873981185 2613 25236256
SGTC_3322 9139058 2.11 µM -0.11342486880991 0.450737420591118 no 1859 0.454846862236891 2751 4908926 YPR165W RHO1
SGTC_1462 k081-0014 26.5 µM -0.113880526665299 0.450539149751625 no 1860 0.454666251299392 2606 3270634
SGTC_2028 5153890 36.43 µM -0.114549704693027 0.450247992061848 no 1861 0.454401023510631 2624 2830968 YPR165W RHO1
SGTC_387 norethindrone acetate 66.7 µM -0.115275667632658 0.449932157683279 no 1862 0.454113312095035 2665 541197
SGTC_684 1140-0066 328 µM -0.115319923775079 0.44991290481585 no 1863 0.454095773412897 2660 6813534
SGTC_1321 1326-2144 215 µM -0.115502567451356 0.449833450098948 no 1864 0.454023392783185 2731 3513030
SGTC_1357 1503-1303 39.5 µM -0.115606561580806 0.449788210864766 no 1865 0.453982181194828 2632 292895
SGTC_2434 5670830 169.91 µM -0.116559588040598 0.449373658436064 no 1866 0.453604531717278 2708 1549830
SGTC_943 3253-1379 105 µM -0.117233900531127 0.449080375816237 no 1867 0.453337351697399 2729 668464
SGTC_2496 diffractaic acid 79.83 µM -0.120167689233289 0.44780469205025 no 1868 0.452175156260945 2787 94870 An apoptosis inducer which activates caspases.
SGTC_2061 5245884 80.95 µM -0.120244496256136 0.447771301652185 no 1869 0.452144735272077 2635 573863
SGTC_2193 5925765 200 µM -0.12116617545051 0.447370648017977 no 1870 0.451779707382483 2715 877370
SGTC_753 1322-0200 289 µM -0.122372797440142 0.446846211075037 no 1871 0.451301890535663 2755 5403907
SGTC_3199 9111318 49.47 µM -0.122470936813053 0.446803560604116 no 1872 0.45126303088126 2709 8548020
SGTC_1648 st011736 69.8 µM -0.123827208764085 0.446214200481268 no 1873 0.45072604406338 2742 2855514
SGTC_1891 st059073 26.2 µM -0.124272793019661 0.446020600286698 no 1874 0.450549644157116 2734 688754
SGTC_409 arachidonic acid 100 µM -0.124417329157687 0.445957804096194 no 1875 0.450492426634823 2626 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes.
SGTC_2166 5933061 31.504 µM -0.124966119439448 0.445719385155382 no 1876 0.450275186401004 3103 2877375
SGTC_515 4092-1064 102 µM -0.125228639128533 0.445605341845055 no 1877 0.450171272480177 2729 717353
SGTC_1752 st044819 83.042 µM -0.125541511267635 0.445469430397005 no 1878 0.450047431867142 2678 441209 YML126C ERG13
SGTC_348 k064-0012 10.7 µM -0.126142498309996 0.445208380018869 no 1879 0.44980956367135 2600 5066323
SGTC_563 tetrahydrosecaminediol 614 µM -0.126270496574913 0.445152784554899 no 1880 0.449758904811692 2737 334274 A psychoactive constituent of the cannabis plant.
SGTC_2486 5283202 22.39 µM -0.126367241585549 0.445110764515457 no 1881 0.449720615836567 2695 1377751
SGTC_2422 chlorphenesin carbamate 384.24 µM -0.128372403967659 0.444239985738343 no 1882 0.448927134442983 2632 2724 A muscle relaxant with antifungal properties.
SGTC_2801 7907800 81.82 µM -0.12977124800233 0.443632670981272 no 1883 0.448373705645428 2709 6620925
SGTC_2223 6903751 107.57 µM -0.130834206040482 0.443171271146739 no 1884 0.44795323152918 2731 5598863
SGTC_2988 9073640 71.4286 µM -0.131022369402662 0.443089602794673 no 1885 0.447878805860583 2787 9102229
SGTC_3186 9110464 49.47 µM -0.131674685680162 0.442806497367182 no 1886 0.44762080452437 2749 17018021
SGTC_2636 apigenin dimethyl ether 100 µM -0.132058422151298 0.442639969274344 no 1887 0.447469041066475 2757 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_1697 st025554 27.742 µM -0.133540886393683 0.441996727538427 no 1888 0.446882815574868 2629 1269519
SGTC_2299 7976368 114.88 µM -0.133571020460071 0.441983653936879 no 1889 0.446870900562174 2736 2979718
SGTC_458 nppb 133 µM -0.133591344853198 0.441974836277201 no 1890 0.446862864322295 2721 4549 A chloride channel blocker.
SGTC_205 1486-1330 71.903 µM -0.13409619961756 0.441755816220473 no 1891 0.446663252384382 2631 4118834
SGTC_2744 captopril 92.04 µM -0.134741098479337 0.441476067043721 no 1892 0.44640828879092 2690 44093 angiotensin-converting enzyme (ACE) inhibitor
SGTC_3177 9107506 49.47 µM -0.135163611317361 0.441292802002647 no 1893 0.446241258492665 2692 8897194
SGTC_2518 prenyletin 46.28 µM -0.135282687604682 0.441241154904232 no 1894 0.446194186265337 2684 3873459 A coumarin with calcium channel inhibitory activity.
SGTC_1183 1254-0324 198 µM -0.135286607304505 0.441239454825192 no 1895 0.446192636775756 2764 5799357
SGTC_1923 st058458 19.1 µM -0.136685214495099 0.440632910693007 no 1896 0.445639808478914 2869 3534982
SGTC_3281 9140613 49.47 µM -0.136842639308361 0.440564647824839 no 1897 0.445577589676225 2683 16013766
SGTC_1828 st055811 49 µM -0.13742334661492 0.440312855629865 no 1898 0.445348089091169 2713 5877589
SGTC_2335 9018011 154.17 µM -0.137975927647273 0.440073281274138 no 1899 0.445129721258478 2763 6458208
SGTC_2229 7354935 190 µM -0.139087914140891 0.43959124038141 no 1900 0.444690339256606 2655 318112
SGTC_1322 1348-1070 12 µM -0.139212901646246 0.439537064473433 no 1901 0.44464095686955 2648 6758089
SGTC_1472 k841-0093 193 µM -0.140010836918991 0.439191225690251 no 1902 0.444325714053629 2757 X1472
SGTC_849 0386-0493 241 µM -0.140582371362093 0.438943541406557 no 1903 0.444099937765338 2661 726119
SGTC_207 4185-0010 4.486 µM -0.141322591731336 0.438622789718836 no 1904 0.443807551550605 2666 3761753
SGTC_3176 9106582 49.47 µM -0.14250957914481 0.438108529525401 no 1905 0.44333875676632 2655 17018027
SGTC_340 k038-0059 454 µM -0.142590000056486 0.438073691078174 no 1906 0.443306997787491 2646 23733424
SGTC_716 1683-5115 658 µM -0.143103345750901 0.437851320353135 no 1907 0.443104281306687 2645 723597
SGTC_2673 kobusone 100 µM -0.143300885508262 0.437765755445847 no 1908 0.443026278258175 2659 6710676 An epoxy ketone and protein crosslinker.
SGTC_69 0096-0274 206.684 µM -0.144280511932176 0.437341470550811 no 1909 0.442639483255429 2962 6741392
SGTC_2523 spermine 47.74 µM -0.144889247768679 0.437077857922471 no 1910 0.442399157945028 2729 1103 A DNA binding polyamine.
SGTC_1227 3909-8010 46.6 µM -0.144959235521195 0.437047551563435 no 1911 0.44237152855088 2675 15982272
SGTC_2731 amoxapine 43.43 µM -0.144992780970547 0.437033025718123 no 1912 0.442358285755473 2650 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine.
SGTC_263 alizarin 107.927 µM -0.145576339594201 0.436780346852408 no 1913 0.44212792362136 2641 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium.
SGTC_1138 3761-0006 1.03 µM -0.146303810983953 0.436465390383096 no 1914 0.441840778750793 2648 12061087
SGTC_1661 st013063 9.66 µM -0.148362894746176 0.435574135471617 no 1915 0.441028190826585 2672 721395
SGTC_2393 9031399 185.94 µM -0.150893360563649 0.434479295778327 no 1916 0.440029919010509 2799 1526623 YDL150W RPC53
SGTC_750 4073-0104 132 µM -0.150923899790704 0.434466085626411 no 1917 0.440017873563468 2739 22330957
SGTC_2416 tofa 880 nM -0.152046370209668 0.433980596893602 no 1918 0.439575181324305 2708 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_3304 9125678 46.087 µM -0.152938245873991 0.433594915509472 no 1919 0.439223487417093 2707 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2
SGTC_2151 5563267 85.4165 µM -0.153181693216234 0.4334896504718 no 1920 0.439127496991532 2721 5310824
SGTC_2055 5235184 200 µM -0.154478016055975 0.432929208581687 no 1921 0.438616421896214 2816 2836034
SGTC_2037 5169046 200 µM -0.155320517089126 0.432565040640251 no 1922 0.438284320798067 2795 5718022
SGTC_934 2950-0684 338 µM -0.156137626197305 0.432211902970763 no 1923 0.437962270318835 2902 1121253
SGTC_1868 st057644 42.7 µM -0.156858360943836 0.431900461245422 no 1924 0.4376782383473 2670 688665
SGTC_3115 9123671 49.47 µM -0.157077849608395 0.431805624862944 no 1925 0.437591747157141 2655 3286988
SGTC_601 0986-0029 62.9 µM -0.157430019516813 0.431653467951682 no 1926 0.437452978138392 2700 24747981
SGTC_878 0828-0289 13.7 µM -0.157507582686179 0.431619957727146 no 1927 0.437422416182992 2700 745350 YLR208W SEC13
SGTC_2183 6420625 130.508 µM -0.158242593674788 0.431302429623199 no 1928 0.437132820827505 2680 2897619
SGTC_208 k072-0098 12.366 µM -0.158620029734751 0.431139392759151 no 1929 0.436984123571881 2689 5948901
SGTC_1413 3910-0535 34.4 µM -0.158738192602044 0.431088353667618 no 1930 0.436937573160541 2803 2876951
SGTC_430 0958-0115 16.4 µM -0.159079433677019 0.430940964973178 no 1931 0.436803145710468 2718 6833180
SGTC_36 0335-0881 14.2 µM -0.159564272440619 0.43073157017297 no 1932 0.43661216238552 2676 23828853
SGTC_1111 tnp00062 510.699 nM -0.160451353795453 0.43034850310421 no 1933 0.436262769553663 2816 676306
SGTC_2969 9091408 28.7 µM -0.16196914895117 0.429693227994639 no 1934 0.43566507430523 2718 4286311
SGTC_3054 9094397 49.47 µM -0.162126422523093 0.429625339585536 no 1935 0.435603149643756 2733 2598354
SGTC_166 k072-0058 166.424 µM -0.162194152501022 0.42959610403382 no 1936 0.435576482229651 2691 5846229
SGTC_1742 st038235 28.8875 µM -0.162304931747833 0.429548287156737 no 1937 0.435532865601252 2828 564103 YBR002C RER2
SGTC_1443 4112-3303 14 µM -0.162430027475597 0.429494291940529 no 1938 0.435483613150232 2702 704433
SGTC_376 3970-0862 59.1 µM -0.162762947058579 0.429350599897782 no 1939 0.435352541565573 2802 3135186
SGTC_2379 9035213 200 µM -0.16359668555491 0.428990789583342 no 1940 0.435024327047866 2735 646551
SGTC_3214 9129694 49.47 µM -0.164481487901901 0.428609006558375 no 1941 0.434676059392976 2784 17158655
SGTC_3029 9088683 49.47 µM -0.165318434829019 0.428247934118558 no 1942 0.43434667478151 2829 25236615
SGTC_978 1416-0512 87.4 µM -0.165906945261075 0.42799407714771 no 1943 0.434115090858955 2743 6814003
SGTC_519 k048-0011 62.8 µM -0.166697491679832 0.427653117844457 no 1944 0.433804039635823 2829 6836379
SGTC_3031 9088762 49.47 µM -0.166770757544298 0.427621521320596 no 1945 0.433775214259065 2679 205253
SGTC_798 1287-0182 476 µM -0.167005575866319 0.427520257061658 no 1946 0.433682830818138 2756 1649755
SGTC_3120 9124077 49.47 µM -0.167074611078082 0.427490486870374 no 1947 0.43365567131632 2672 18774327 YGL155W CDC43
SGTC_60 0986-0278 202 µM -0.167149688497344 0.427458111554611 no 1948 0.433626135073802 2700 3110598
SGTC_1840 st055363 71 µM -0.168608616747621 0.426829081377376 no 1949 0.433052251211335 2749 676033
SGTC_344 k064-0035 6.43 µM -0.168949182487421 0.426682270086636 no 1950 0.432918306584898 2718 5088750
SGTC_1603 st002045 67.8 µM -0.170130214560344 0.426173228858427 no 1951 0.432453866050718 2753 5887985
SGTC_2688 kanamycin b 96.69 µM -0.170415459340015 0.426050302802285 no 1952 0.432341707586358 2820 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis.
SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM -0.170538518459354 0.42599727277104 no 1953 0.432293322329872 2680 1241132 A phosphatase inhibitor.
SGTC_2960 9079389 5.97 µM -0.171483207211466 0.425590221419237 no 1954 0.431921916783131 2831 16457355
SGTC_637 1181-0519 7.26 µM -0.171732169673609 0.425482960639554 no 1955 0.431824046888034 2717 6252091 YGR060W ERG25
SGTC_1480 1070-0044 41.2 µM -0.171755441565534 0.425472934665694 no 1956 0.431814898663901 2800 3124987
SGTC_923 1900-2434 73.3 µM -0.172329793739529 0.425225508107463 no 1957 0.431589131352334 2698 5910570
SGTC_2836 9010338 19.48 µM -0.173237493044585 0.424834538217535 no 1958 0.431232376983781 2737 2994051
SGTC_1659 st012954 42.1 µM -0.174348782933455 0.42435597722067 no 1959 0.430795681520776 2845 24207262
SGTC_2221 6807166 181.081 µM -0.174418423472418 0.42432599123012 no 1960 0.430768318198866 2729 674925
SGTC_1133 3473-0247 50 µM -0.17507051231158 0.424045234527362 no 1961 0.430512114085631 2802 711311
SGTC_3129 9127257 49.47 µM -0.175660780052038 0.423791128116625 no 1962 0.43028022454759 2747 837894
SGTC_2445 5742597 35.57 µM -0.176846779071806 0.423280659171206 no 1963 0.429814371858808 2735 1774255
SGTC_152 4469-0003 551.229 µM -0.1773170613694 0.423078279337483 no 1964 0.429629675051319 2724 697280
SGTC_2483 5729050 27.16 µM -0.177756336116124 0.422889261529458 no 1965 0.429457169937152 2807 2865180
SGTC_1337 1486-1011 40.3 µM -0.177817213587776 0.422863067646058 no 1966 0.429433264149742 2716 X1337
SGTC_321 4534-3890 65.3 µM -0.179552862626194 0.422116410022463 no 1967 0.428751806653097 2845 699746
SGTC_2771 fluoxetine 41.05 µM -0.180786386763556 0.421585931099871 no 1968 0.428267624414154 2901 3386 A selective serotonin reuptake inhibitor.
SGTC_1208 2323-2347 50.3 µM -0.182854955703712 0.420696659709459 no 1969 0.427455913524063 2853 5412760
SGTC_891 0929-0073 133 µM -0.183350767007401 0.420483571894865 no 1970 0.427261401584675 2873 5603632
SGTC_1716 st033144 30.6155 µM -0.184456099965863 0.42000861024374 no 1971 0.426827831667016 2846 674617
SGTC_3187 9109394 49.47 µM -0.184477394428819 0.419999461152881 no 1972 0.426819479721061 2766 17098090
SGTC_500 h-89 112 µM -0.184688664152777 0.419908692204616 no 1973 0.426736618957857 2912 449241 Protein kinase A inhibitor; also known to inhibit several other kinases.
SGTC_2149 5554786 194.827 µM -0.187458067819107 0.418719254103312 no 1974 0.425650748941968 2749 745063 YPR165W RHO1
SGTC_1529 apigenin 74 µM -0.187502784846339 0.418700054539326 no 1975 0.42563322020997 2966 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_2126 5251174 33.877 µM -0.187524648669354 0.418690667226642 no 1976 0.42562464981239 2859 790722
SGTC_1187 1391-0724 117 µM -0.188152994326274 0.418420904518412 no 1977 0.425378359699037 2779 6997986
SGTC_271 rotenone 740 µM -0.188711855894072 0.418181005100384 no 1978 0.425159329445401 2866 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria.
SGTC_33 0986-0033 35.816 µM -0.189365109937833 0.417900624932349 no 1979 0.424903333969966 2729 2848082
SGTC_1484 3473-2379 286 µM -0.190164902972417 0.417557406263378 no 1980 0.424589956308394 2736 671917
SGTC_771 0250-0039 27.3 µM -0.190213710869693 0.417536463148232 no 1981 0.424570833770963 2736 3005115
SGTC_361 000s-0510 1.45 µM -0.190258460855775 0.417517261458934 no 1982 0.424553301246157 2835 660
SGTC_763 3453-1109 128 µM -0.19030541058106 0.417497116099007 no 1983 0.424534907049541 2785 1560353
SGTC_2050 5263056 171 µM -0.191618310719763 0.416933859984864 no 1984 0.424020599209344 2871 763468 YGL055W OLE1
SGTC_3246 9135460 32.98 µM -0.192376186480413 0.416608796136131 no 1985 0.423723772220458 2838 41446951
SGTC_1466 k213-0079 57.5 µM -0.193889124585203 0.415960045884342 no 1986 0.423131349717545 2733 3657981
SGTC_2310 7668677 200 µM -0.194490724503222 0.41570214240633 no 1987 0.422895828919199 2940 2197143
SGTC_2039 Aminomethylbenzodioxan 200 µM -0.194514829097451 0.415691809618964 no 1988 0.422886392767331 2737 15053
SGTC_2866 9034245 58.44 µM -0.194946702854564 0.415506690492152 no 1989 0.422717335969493 2850 6462273
SGTC_2837 9008476 45.46 µM -0.195448686701571 0.41529154282056 no 1990 0.422520852494987 2957 2992805
SGTC_2625 euphol 100 µM -0.195598072383134 0.41522752179333 no 1991 0.422462384576701 2879 6708538 A triterpene alcohol.
SGTC_221 trifluoperazine 10.304 µM -0.19634120940732 0.414909074980467 no 1992 0.422171554303771 2769 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1
SGTC_661 1304-0007 33.6 µM -0.196842298100827 0.41469438152346 no 1993 0.421975474759253 2764 3117130
SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM -0.197581353783959 0.414377776676458 no 1994 0.421686312361513 2854 616764
SGTC_2995 9067767 71.4286 µM -0.198117328965177 0.414148204486351 no 1995 0.421476633499728 2844 11673567
SGTC_2190 6049624 200 µM -0.198220878782801 0.414103854769178 no 1996 0.421436126337805 2740 2265554
SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM -0.198225294590057 0.414101963531837 no 1997 0.421434398957593 2743 91467 include heat shock
SGTC_3263 9137018 49.47 µM -0.19847085335575 0.41399679679109 no 1998 0.421338343397483 2789 43844957
SGTC_3040 9091894 49.47 µM -0.198868500738254 0.413826507343276 no 1999 0.421182805054616 2769 25236966
SGTC_506 n9-isopropylolomoucine 153 µM -0.199330944488241 0.413628489727921 no 2000 0.421001937316345 2884 6610355
SGTC_726 3448-4391 34.2 µM -0.200803828292531 0.412997950035435 no 2001 0.420425984679214 2937 1356692
SGTC_2218 6965428 192.983 µM -0.200917337854321 0.412949366027505 no 2002 0.420381605249934 2753 675684
SGTC_2633 5,7-dihydroxyisoflavone 100 µM -0.201360433941295 0.412759726192365 no 2003 0.420208375338439 2916 5377381
SGTC_407 eburnamonine 100 µM -0.202151368679613 0.412421266201988 no 2004 0.41989919516918 2737 3195
SGTC_3172 9105863 49.47 µM -0.202524345658622 0.412261682963443 no 2005 0.419753413825035 2802 2348785
SGTC_351 caspofungin 25 nM -0.203856125862143 0.411691981358634 no 2006 0.419232965769879 2792 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1
SGTC_2669 eugenol 100 µM -0.204527420807504 0.411404888973278 no 2007 0.418970683075057 2806 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism.
SGTC_3327 9140648 26.9345 µM -0.204581717127872 0.411381670163512 no 2008 0.418949470447569 2887 8029710
SGTC_1064 honokiol 6.76 µM -0.207805597391838 0.410003596903017 no 2009 0.417690380967353 2862 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis.
SGTC_1551 6-bromo-3'-methylflavone 63.5 µM -0.208710818737865 0.409616851841679 no 2010 0.417336997001215 2936 688751
SGTC_906 1165-0455 526 µM -0.209623848545281 0.409226859777821 no 2011 0.416980632361794 2776 3252859
SGTC_2102 5377816 72.7585 µM -0.210276880286956 0.40894797850949 no 2012 0.416725789377118 2960 1379702
SGTC_1736 st036774 51 µM -0.210683252031398 0.40877445818164 no 2013 0.416567222110481 3056 1272247
SGTC_2984 9022109 38.96 µM -0.211443341158671 0.4084499489072 no 2014 0.416270669902048 2840 6459207
SGTC_520 3584-0023 682 µM -0.212136360856572 0.408154128670738 no 2015 0.416000326664973 2839 1340790
SGTC_881 0833-0569 170 µM -0.212494895148034 0.4080011063693 no 2016 0.415860479967189 2807 5418700
SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM -0.215504690688035 0.406717082234746 no 2017 0.41468692766996 2804 6708514
SGTC_1022 4477-0945 21.3 µM -0.215863784263271 0.406563954153992 no 2018 0.414546963756792 2804 4648966
SGTC_2109 5483026 200 µM -0.216476012544483 0.406302914931182 no 2019 0.414308360547306 2828 759335
SGTC_2783 7738165 71.43 µM -0.216768745523331 0.406178115428911 no 2020 0.414194285140338 2858 17201110
SGTC_1614 st002383 48.6 µM -0.218896122974969 0.405271447506383 no 2021 0.413365483327171 2808 1947235
SGTC_2790 5423970 71.43 µM -0.219127453693769 0.405172887111424 no 2022 0.413275382733582 2957 1376240 YKL165C | YIL048W MCD4 | NEO1
SGTC_2887 9044784 58.44 µM -0.22032822543861 0.4046613849872 no 2023 0.412807769749064 2801 6465546
SGTC_1230 0170-0365 3.77 µM -0.220816670688523 0.404453364700655 no 2024 0.412617591318035 2901 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1
SGTC_1217 1183-1422 255 µM -0.223170487845642 0.403451294814239 no 2025 0.411701410005776 2933 2849664
SGTC_2417 cerulenin 830 nM -0.223240467451259 0.403421512677323 no 2026 0.411674179034504 2789 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1
SGTC_3096 9117468 49.47 µM -0.223405012422575 0.403351487326758 no 2027 0.411610151779167 2952 41316311
SGTC_2664 lyso-paf C-16 73.48 µM -0.22377174814376 0.403195426876564 no 2028 0.411467457124897 2803 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_1767 st044992 70.3 µM -0.225167162633988 0.402601764349552 no 2029 0.410924616972864 2869 9600693
SGTC_1199 1638-0010 4.46 µM -0.225216113606158 0.402580942808034 no 2030 0.410905577295977 2796 3111136
SGTC_403 arphamenine a 50 µM -0.226138506852099 0.402188649940697 no 2031 0.410546848035231 2802 5487158 An arginine aminopeptidase inhibitor.
SGTC_2829 7992743 58.44 µM -0.226828614537936 0.401895212268368 no 2032 0.410278506193065 3011 16462845
SGTC_588 3970-1144 52.9 µM -0.227517214833241 0.401602470659163 no 2033 0.410010792349753 2949 1888707
SGTC_2650 prasterone 100 µM -0.228218562157597 0.401304366714496 no 2034 0.409738165831307 2809 16759247 A steroid and weak partial agonist of the androgen receptor.
SGTC_2117 5521686 200 µM -0.228517866635221 0.401177166417268 no 2035 0.409621833988879 2783 803312
SGTC_735 3076-0345 636 µM -0.228841004565323 0.401039848987932 no 2036 0.409496247637496 2961 2888990
SGTC_705 1124-0212 310 µM -0.229569183194875 0.400730454392494 no 2037 0.409213277789809 2914 9554485
SGTC_1035 k081-0041 55.2 µM -0.229689070175568 0.400679521778797 no 2038 0.40916669430059 2888 731709
SGTC_3329 9141233 27.5565 µM -0.231080270213086 0.400088610038661 no 2039 0.408626221219397 2970 4909101 YNL103W MET4
SGTC_3118 9124250 49.47 µM -0.231326535529514 0.399984032714242 no 2040 0.408530566653093 2878 1504786
SGTC_1562 morin hydrate 59.1 µM -0.231635325089213 0.399852914413433 no 2041 0.408410634071985 2993 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase.
SGTC_1500 4488-1866 171 µM -0.231894665840336 0.399742801801114 no 2042 0.408309913829627 2966 2900003
SGTC_729 4092-0585 94.1 µM -0.234534445222557 0.398622441846145 no 2043 0.407285047674085 2796 2169061
SGTC_2908 7930301 100 µM -0.235636999974914 0.398154748566348 no 2044 0.406857179972844 2824 2223178
SGTC_2759 disulfiram 3.38 µM -0.236498875777317 0.397789250850016 no 2045 0.406522789770534 2805 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_1738 st035555 74 µM -0.236956136633127 0.397595375549989 no 2046 0.40634540955643 2943 5331140
SGTC_2924 9010168 62.78 µM -0.237536471372449 0.397349354236804 no 2047 0.406120314311599 2918 2993929
SGTC_48 0382-0018 55 µM -0.237763587878051 0.397253083845316 no 2048 0.406032230759224 3093 762596
SGTC_1363 1636-0063 10.4 µM -0.238487645536152 0.396946211310758 no 2049 0.405751448197248 2834 6072185
SGTC_1692 fluoroquinolonic acid 71 µM -0.238801246021254 0.396813319895266 no 2050 0.405629851998039 2948 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2
SGTC_1693 xanthone 101.9 µM -0.238875158451428 0.396782000490786 no 2051 0.405601194341839 2865 7020 An insecticide.
SGTC_1170 0310-0127 64.8 µM -0.240860607348202 0.395940942839295 no 2052 0.4048315770841 2905 774975
SGTC_582 0987-0078 156 µM -0.240873149883676 0.395935631220497 no 2053 0.404826716402155 2870 1625765
SGTC_1096 rimcazole 32.2 µM -0.241457797062888 0.395688061356281 no 2054 0.404600160977963 2809 18528119 A dopamine reuptake inhibitor.
SGTC_2979 9012552 45.46 µM -0.242271868392251 0.395343411546067 no 2055 0.40428475515626 2938 17100905
SGTC_1654 st012436 41.8 µM -0.244416707612582 0.394435752907659 no 2056 0.403454051651226 2871 4323132
SGTC_2471 5466956 24.79 µM -0.24461618646485 0.394351365970033 no 2057 0.403376814888419 2855 724419
SGTC_3244 9134489 49.47 µM -0.245131862251687 0.394133239012107 no 2058 0.403177166440315 2913 16584271
SGTC_1165 k072-0275 30.3 µM -0.245992201745306 0.393769395847555 no 2059 0.40284413458287 2901 6153523 YGL055W OLE1
SGTC_503 tyrphostin 8 294 µM -0.246530326278721 0.393541866597142 no 2060 0.402635865865047 2968 92970 A tyrosine kinase inhibitor. YOR207C RET1
SGTC_958 1222-0007 33 µM -0.247250385204234 0.3932374689071 no 2061 0.40235722685527 3012 7312461
SGTC_972 1319-0219 195 µM -0.247951116078864 0.392941304605604 no 2062 0.402086114785037 2938 23903702
SGTC_937 3122-0005 46.7 µM -0.248237333400334 0.392820352505932 no 2063 0.401975391132645 2997 759535
SGTC_1964 st076914 61 µM -0.249378094078032 0.392338383283051 no 2064 0.401534164188025 2823 24208661
SGTC_1938 st074717 56.4 µM -0.249384573846178 0.392335646064169 no 2065 0.401531658281209 2801 17250979
SGTC_3352 9151559 45.5865 µM -0.249757349761561 0.392178185007663 no 2066 0.401387502272788 2930 17159339
SGTC_2897 9048598 12.99 µM -0.250582407012936 0.391829742507247 no 2067 0.401068492500734 2854 6467404
SGTC_3092 9117248 49.47 µM -0.251773046690382 0.391327058304276 no 2068 0.400608245974752 2843 17141857
SGTC_2389 9091542 195.52 µM -0.252127518339469 0.391177436540119 no 2069 0.400471250162498 2911 3626624 YOL127W RPL25
SGTC_3261 9137475 49.47 µM -0.252276706751836 0.39111446922754 no 2070 0.400413595649129 2831 17027690
SGTC_1544 7-methoxy-4-methylcoumarin 105 µM -0.253573647472834 0.390567195444457 no 2071 0.399912478799265 2863 390807
SGTC_3262 9137218 49.47 µM -0.253778226774725 0.390480888293714 no 2072 0.39983344770216 2784 17650664
SGTC_1634 st006576 41 µM -0.254397581631259 0.39021963009809 no 2073 0.399594209551372 3028 3915356
SGTC_3163 9099914 49.47 µM -0.254534668120921 0.39016181054415 no 2074 0.399541262255581 2947 16268368
SGTC_1102 cgs 12066b 26.1 µM -0.25546867749337 0.389767934158454 no 2075 0.399180566442831 2894 6438352 A 5-HT1B full agonist.
SGTC_459 nigericin 15.3 µM -0.25582780761749 0.389616517306156 no 2076 0.399041900432922 2971 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification.
SGTC_1968 st069590 43.6 µM -0.257425913729295 0.388942925440423 no 2077 0.398425000256878 3008 6384066
SGTC_3133 9127736 49.47 µM -0.258711720505813 0.388401207957068 no 2078 0.397928837859464 2944 27243420
SGTC_29 0299-0004 12.984 µM -0.259158395164285 0.388213072194365 no 2079 0.397756515264346 2875 16871 A napthoquinone isolated from Swertia calycina.
SGTC_875 0709-0210 25.7 µM -0.259170543605665 0.388207955735045 no 2080 0.397751828796211 2888 6251364
SGTC_2748 diazoxide 86.69 µM -0.260371798312708 0.387702129098584 no 2081 0.397288497306306 2951 3019 A potassium channel activatior.
SGTC_2561 acetosyringone 100 µM -0.260503337021517 0.387646752085096 no 2082 0.397237770790166 2839 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent.
SGTC_2377 9073351 62.6 µM -0.261267849107078 0.387324942323775 no 2083 0.396942979200353 2850 7337946 YHR072W ERG7
SGTC_3111 9122088 49.47 µM -0.261361820929334 0.387285391649312 no 2084 0.396906748250602 2912 16876704
SGTC_1403 3909-7815 62.9 µM -0.262289412701138 0.386895051495065 no 2085 0.396549161911297 2846 6615483
SGTC_406 estrone 100 µM -0.262724826299245 0.386711864396019 no 2086 0.3963813400873 3053 5870 A steroid.
SGTC_3140 9094243 49.47 µM -0.262861449913076 0.386654389343952 no 2087 0.396328685089976 2846 19291112
SGTC_2175 5807670 165.306 µM -0.264479687042361 0.385973816059876 no 2088 0.39570515755578 3003 241186
SGTC_890 0929-0006 47.2 µM -0.264525790782479 0.385954431587352 no 2089 0.395687397094778 2875 1378169
SGTC_2099 5377090 177.372 µM -0.267987245049548 0.384499867951886 no 2090 0.394354568368602 2962 2243829
SGTC_1132 3456-3614 2.5 µM -0.268178440971223 0.384419571243437 no 2091 0.394280984492263 3142 3125502
SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM -0.26899364058824 0.384077266877529 no 2092 0.393967288222961 2912 6708561
SGTC_1197 1601-0112 267 µM -0.270062176988004 0.383628722709529 no 2093 0.393556209837056 2872 7350313
SGTC_1995 st072814 61.1 µM -0.270094237942958 0.383615266749152 no 2094 0.393543877445251 2892 5769371
SGTC_3146 9095609 49.47 µM -0.271712060271054 0.382936450410613 no 2095 0.39292171365301 2952 17173999
SGTC_516 3992-2719 87.3 µM -0.272498256355654 0.382606702804452 no 2096 0.392619465896398 2821 5350887 YDR037W KRS1
SGTC_2754 granisetron 64.02 µM -0.273906777279843 0.382016151646045 no 2097 0.392078131592177 3030 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients.
SGTC_306 1672-3436 11.6 µM -0.274037390322104 0.381961403343214 no 2098 0.392027943881433 2985 6797378
SGTC_1334 1486-0610 236 µM -0.274735583748995 0.381668785758821 no 2099 0.391759695417259 2985 3742339
SGTC_1501 4491-0275 38.4 µM -0.275217735510628 0.381466752151124 no 2100 0.391574480975428 2972 5104718
SGTC_270 tamoxifen 5.46 µM -0.277366766711774 0.38056664795878 no 2101 0.39074924861103 3097 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen. YIL048W NEO1
SGTC_3205 9113483 49.47 µM -0.277605673596687 0.380466623580344 no 2102 0.390657538188064 3080 17018033
SGTC_686 1319-0111 510 µM -0.280992963582631 0.379049312208037 no 2103 0.389357898375461 3062 4562600
SGTC_2447 5741742 33.78 µM -0.281108444225806 0.379001021275766 no 2104 0.389313612329334 2984 1776504
SGTC_504 lovastatin 124 µM -0.282156724880029 0.378562744664891 no 2105 0.38891166960682 2931 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1
SGTC_1081 sertraline 6 µM -0.283472906664215 0.378012682188059 no 2106 0.388407173800808 3015 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1
SGTC_16 erodoxin 22.806 µM -0.284406197439642 0.377622788345623 no 2107 0.388049555074873 3010 3967339 Erodoxin inhibits Ero1. YML130C ERO1
SGTC_662 k832-1615 104 µM -0.285121294026375 0.377324132172691 no 2108 0.387775608290013 3003 5878478
SGTC_1488 4013-0813 75.9 µM -0.285168997455024 0.377304211704943 no 2109 0.387757335540281 2921 2910057
SGTC_2164 5685496 200 µM -0.286030184532021 0.376944644914957 no 2110 0.387427501495028 3002 759046
SGTC_2138 5575593 77.673 µM -0.286061618175923 0.376931522611768 no 2111 0.387415463966837 2922 762213
SGTC_1050 3232-1156 69.3 µM -0.286164464441475 0.376888589356782 no 2112 0.38737607969928 2947 700529
SGTC_26 0302-0163 425.158 µM -0.286662502475499 0.376680704528637 no 2113 0.387185375875593 2916 3100915
SGTC_1459 k035-0031 35.7 µM -0.288207152820256 0.376036183489097 no 2114 0.386594086913676 2873 3877128 YMR208W ERG12
SGTC_2237 6667747 47.222 µM -0.289914652545703 0.375324114124699 no 2115 0.385940765849939 2903 729940 YDL015C TSC13
SGTC_2196 6573537 42.6665 µM -0.290838567214229 0.374938995863739 no 2116 0.385587393660062 3027 2903087
SGTC_561 1550-0330 72.9 µM -0.291028758641122 0.374859733232686 no 2117 0.385514662395417 2925 6812934
SGTC_853 0419-0306 21 µM -0.293881068097863 0.373671663736862 no 2118 0.384424392560624 2901 762713
SGTC_2944 9067346 25.62 µM -0.294486720131693 0.37341954613293 no 2119 0.38419300478381 3096 6473075
SGTC_2563 tomatine 8.54 µM -0.295000561444901 0.373205689479833 no 2120 0.383996725406555 3096 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties.
SGTC_3279 9140807 49.47 µM -0.295041214311521 0.373188771747567 no 2121 0.38398119791413 2901 45595718
SGTC_3142 9086498 49.47 µM -0.295762201694648 0.372888772751858 no 2122 0.383705845440161 3045 25236367
SGTC_1972 st070201 17.4 µM -0.29825357396772 0.371852720395528 no 2123 0.38275481759727 3069 2829099
SGTC_550 4123-0385 25.7 µM -0.298407479811967 0.371788748047606 no 2124 0.382696090459749 2935 5731123
SGTC_3202 9113761 49.47 µM -0.300582695598563 0.370884979384665 no 2125 0.381866364245204 3087 4798415
SGTC_1644 st010134 20.9 µM -0.300957813871094 0.37072919534199 no 2126 0.38172333180515 3023 3818134
SGTC_3017 9080681 49.47 µM -0.304041535659628 0.36944935210004 no 2127 0.380548123608423 3006 16451914
SGTC_8 0354-0001 70 µM -0.304707208073438 0.36917326593442 no 2128 0.380294579641053 2968 4993152
SGTC_2639 lactacystin 53 µM -0.304826784401502 0.369123679060643 no 2129 0.380249040376943 3091 3870 A proteasome inhibitor.
SGTC_2605 digitonin 300 nM -0.306131103737735 0.368582935026666 no 2130 0.379752413341765 3082 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_3323 9138564 53.9225 µM -0.307249373625279 0.3681195303414 no 2131 0.379326783524465 3119 43912313 YNL103W MET4
SGTC_1575 cyproterone acetate 48 µM -0.307413797590436 0.368051410145308 no 2132 0.379264213685303 3008 9880 An androgen receptor antagonist and liver toxin.
SGTC_2973 9094665 17.96 µM -0.308353942182275 0.367661991714316 no 2133 0.378906512171132 3156 25237061 YIL048W NEO1
SGTC_732 3970-1727 52.7 µM -0.308919733179024 0.367427700272304 no 2134 0.378691292797102 3049 1275699
SGTC_117 lucigenin 22.078 µM -0.309723648337092 0.367094887591313 no 2135 0.378385558863076 3021 65100 An acridine derivative; a dye stuff and potential carcinogen.
SGTC_1550 gossypolone 36.6 µM -0.310318285680981 0.366848778017086 no 2136 0.378159463546043 2951 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_997 3996-0078 137 µM -0.310395657053282 0.366816759435298 no 2137 0.378130048168391 3016 735687
SGTC_1030 k029-0042 36.7 µM -0.311196095476796 0.366485568554476 no 2138 0.377825775568042 3009 6080581
SGTC_3341 9147222 25.867 µM -0.311256130181936 0.366460732488206 no 2139 0.377802957482798 3069 1939759
SGTC_765 1319-0117 244 µM -0.31127689668474 0.366452141616914 no 2140 0.377795064616968 2934 3487746 YGL099W LSG1
SGTC_966 1300-0360 30.2 µM -0.311788296535075 0.36624060231039 no 2141 0.377600709507345 2950 70588
SGTC_74 000s-0487 160.283 µM -0.313357280914787 0.36559184960173 no 2142 0.377004617936731 2929 677548
SGTC_796 1234-0020 70.7 µM -0.313636962054856 0.365476245734388 no 2143 0.37689839167009 2950 46495034
SGTC_378 3970-0959 8.33 µM -0.314822664557883 0.364986281317237 no 2144 0.376448151147918 3085 6615653
SGTC_596 1155-0152 116 µM -0.315402026745414 0.36474695324958 no 2145 0.376228214095335 2986 280313
SGTC_2154 5570129 200 µM -0.315453947530585 0.36472550792297 no 2146 0.376208505925659 2974 673366
SGTC_1642 st009582 77.7 µM -0.316031704250825 0.364486900245693 no 2147 0.375989221952914 3111 6739311
SGTC_1727 st034309 9.9045 µM -0.316550761594781 0.364272579580719 no 2148 0.37579225110236 3210 870305
SGTC_1084 voriconazole 435 nM -0.318336471029441 0.363535578136218 no 2149 0.37511486110084 3087 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_279 1273-0055 2.93 µM -0.320281001029591 0.362733602078495 no 2150 0.374377662098458 3033 2847562
SGTC_1900 st060200 72.8 µM -0.321559793432787 0.362206521726025 no 2151 0.373893103712565 2949 688945
SGTC_1980 st071811 45.7 µM -0.321962451431387 0.362040612039189 no 2152 0.373740570262951 3115 4974850
SGTC_1085 doxorubicin 7.67 µM -0.324034614143981 0.36118721643162 no 2153 0.372955914259168 3079 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_149 3970-0822 46.1 µM -0.324339990888642 0.361061508912597 no 2154 0.372840323154678 3024 3114250 YBL034C STU1
SGTC_2550 chrysin dimethyl ether 71.87 µM -0.324353529931557 0.361055935949108 no 2155 0.37283519862559 2908 88881 An O-methylated flavonoid and antioxidant.
SGTC_841 0251-0215 91.2 µM -0.325844619957029 0.360442351711562 no 2156 0.372270958806721 3028 3888614
SGTC_2293 7624732 200 µM -0.326759763390682 0.360065947539535 no 2157 0.371924797217624 2934 894453
SGTC_1965 Pectolinarigenin 58.4 µM -0.328424028448757 0.359381772825117 no 2158 0.371295538783713 3001 5320438 An anti-inflammatory.
SGTC_3269 9137823 49.47 µM -0.329001904134093 0.359144315024262 no 2159 0.371077124396865 2955 17682936
SGTC_2831 7999036 19.48 µM -0.330056435717027 0.358711132434488 no 2160 0.370678659805826 3232 2988270
SGTC_3321 9137793 26.8275 µM -0.331144853296326 0.358264220615024 no 2161 0.370267536498206 3039 4904192
SGTC_1288 0973-0013 65.5 µM -0.332708846296465 0.357622374192408 no 2162 0.369677035630678 3100 4315430
SGTC_2694 st077685 81.9 µM -0.332970996636668 0.35751482975848 no 2163 0.369578088228844 2947 2838096
SGTC_1827 berberine 7.24 µM -0.33461571566443 0.356840359447773 no 2164 0.368957494151114 2988 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_2992 9074591 71.4286 µM -0.334918908253038 0.356716074270391 no 2165 0.368843129150165 3107 17741321
SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM -0.336242878703912 0.356173528625859 no 2166 0.368343860388082 3104 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_2594 a-mangostin 100 µM -0.337026650680889 0.355852486269569 no 2167 0.36804840492922 3144 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis.
SGTC_28 pentachloropyridine N-oxide 1.606 µM -0.337196436981394 0.35578295323428 no 2168 0.367984411528795 3101 140250 A respiratory chain inhibitor.
SGTC_3332 9141069 11.198 µM -0.337452860058582 0.355677948704736 no 2169 0.367887771190887 2964 17332883
SGTC_1909 st060837 51.5 µM -0.337760165368307 0.355552122470158 no 2170 0.367771965450877 3033 678937
SGTC_791 1348-1292 225 µM -0.337891916142495 0.355498181903252 no 2171 0.36772231982374 3047 5437054
SGTC_2489 cantharidin 73.42 µM -0.338159480137756 0.35538864645608 no 2172 0.367621504582176 2964 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_294 k038-0071 157 µM -0.341938643228262 0.353842810875628 no 2173 0.366198533725305 3062 24152826
SGTC_275 trichlorophene 5.69 µM -0.342387124902376 0.353659522381687 no 2174 0.366029788242632 3096 62616
SGTC_105 0111-0055 734.78 µM -0.342521522895918 0.353604602313425 no 2175 0.365979224767357 3092 5179370
SGTC_2526 patulin 37.61 µM -0.343031416925597 0.353396268180034 no 2176 0.365787412614561 3167 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.
SGTC_2649 anisomycin 9.56 µM -0.343718033765422 0.353115797471354 no 2177 0.365529173810079 3064 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_290 2043-6722 48.1 µM -0.346527906174865 0.351968847472102 no 2178 0.364473007861486 3115 773758 YLR208W SEC13
SGTC_2817 7995342 71.43 µM -0.347183287583415 0.351701523233635 no 2179 0.3642268127352 2953 18879975
SGTC_198 3454-2873 16.191 µM -0.349505125084844 0.350755057091703 no 2180 0.363355061934513 3034 710957
SGTC_3241 9133421 49.47 µM -0.350235468261963 0.350457533482325 no 2181 0.36308099527372 3072 17018221
SGTC_370 0180-0345 38.7 µM -0.350499760427324 0.350349890032915 no 2182 0.362981834956143 2929 3989527
SGTC_2171 5739187 198.077 µM -0.350541161068928 0.350333029070902 no 2183 0.362966302596781 2951 2262761
SGTC_3086 9117350 49.47 µM -0.350954834024346 0.350164571459131 no 2184 0.362811116490784 3083 2679265
SGTC_1615 st002656 86.5 µM -0.351528418583557 0.349931042760497 no 2185 0.362595978103126 3042 1584458
SGTC_1078 idebenone 36.1 µM -0.3517989782906 0.349820907019305 no 2186 0.362494512425676 3096 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen.
SGTC_2603 homopterocarpin 100 µM -0.354248495662801 0.348824367066262 no 2187 0.361576331312954 3133 101795 A weak amylase inhibitor.
SGTC_58 0957-0393 9 µM -0.354333532591722 0.34878979007114 no 2188 0.361544470206732 3157 6997992
SGTC_94 0334-0113 514.748 µM -0.354914907414523 0.348553430024896 no 2189 0.361326670041634 3051 6795178
SGTC_2348 9022543 33.42 µM -0.355250855815367 0.348416875773781 no 2190 0.361200834338143 3152 3162678 YDL140C RPO21
SGTC_664 1222-0054 14.9 µM -0.355517484642973 0.348308512099706 no 2191 0.361100974254524 3054 6813991
SGTC_919 tnp00227 403.569 nM -0.356139019233113 0.348055955195545 no 2192 0.36086822862333 3032 1269246 A methoxyflavone. YNL221C POP1
SGTC_210 3551-0445 56.827 µM -0.356711741125681 0.347823292688893 no 2193 0.360653807451259 3161 2865180 YOR207C RET1
SGTC_613 3914-0030 117 µM -0.356784063940889 0.347793916345223 no 2194 0.360626733648403 2943 1145395
SGTC_2396 5342950 42.78 µM -0.35725618081466 0.34760217265698 no 2195 0.36045001545367 3119 1886677
SGTC_3030 9087619 49.47 µM -0.357378542197591 0.3475524836455 no 2196 0.360404219193174 3080 25236973
SGTC_3157 9099274 49.47 µM -0.357515919031242 0.34749670021932 no 2197 0.360352805478199 3181 17217662
SGTC_3046 9092212 49.47 µM -0.359046006435341 0.346875614299359 no 2198 0.359780336299723 3087 25236637
SGTC_1952 st077036 64.1 µM -0.359527304470904 0.346680332991529 no 2199 0.359600327686178 3014 2937007
SGTC_3043 9092303 49.47 µM -0.359759878821803 0.346585983136637 no 2200 0.359513354516981 3095 25236084
SGTC_1865 st057639 52.2 µM -0.360693340330769 0.346207395907844 no 2201 0.359164351851666 3019 688818
SGTC_1006 4099-6547 255 µM -0.361245174169645 0.345983658971586 no 2202 0.358958087411054 3134 3146833
SGTC_1450 4112-4260 37.6 µM -0.361904858145873 0.345716265547809 no 2203 0.358711564705424 3181 1633175
SGTC_389 tpck 16.7 µM -0.364744077960086 0.344566308277455 no 2204 0.357651226263672 3112 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.
SGTC_1581 himbacine 57.9 µM -0.364989134216548 0.344467121295927 no 2205 0.357559758605527 3035 5281825 An alkaloid muscarinic receptor antagonist.
SGTC_3198 9112019 49.47 µM -0.365210596563231 0.344377493192726 no 2206 0.357477104450811 3034 45595555
SGTC_2873 9040596 71.43 µM -0.365871581286508 0.344110037814304 no 2207 0.357230451563126 3160 6463863
SGTC_134 0269-0018 6.916 µM -0.366301229965632 0.343936230134435 no 2208 0.357070155951796 3116 4378915
SGTC_3099 9120367 49.47 µM -0.366373334340172 0.343907064663105 no 2209 0.357043257339974 3022 24824940
SGTC_1780 st038448 24.544 µM -0.368482056811023 0.343054519712243 no 2210 0.356256911001286 3217 728868 YDL195W SEC31
SGTC_192 3455-0609 60.9 µM -0.369439910776732 0.342667528001753 no 2211 0.3558999271095 3179 3769639
SGTC_282 k297-0036 65.7 µM -0.37000428526749 0.342439586936795 no 2212 0.355689648731517 3175 5061378
SGTC_1274 0865-0114 173 µM -0.370182608208865 0.342367577319209 no 2213 0.355623217116705 3096 870624
SGTC_2120 5538279 151.968 µM -0.372112887794039 0.341588467171501 no 2214 0.35490440059361 3081 2058197
SGTC_2555 cholic acid 100 µM -0.372904674103653 0.341269076863296 no 2215 0.35460969655533 3224 6708657 Influences liver metabolism.
SGTC_971 1315-0384 26.7 µM -0.374044175556736 0.340809624972398 no 2216 0.354185725167629 3081 6769120
SGTC_1415 3966-0071 78.1 µM -0.374145871188411 0.340768632318907 no 2217 0.354147896308806 3141 2893185
SGTC_2776 terbinafine 19.92 µM -0.375019949197166 0.340416376405186 no 2218 0.353822815144439 3120 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_41 0478-0632 82.643 µM -0.375580502920716 0.340190544896391 no 2219 0.353614393865072 3161 3750424
SGTC_110 0850-0284 111.64 µM -0.37730967092367 0.339494272569075 no 2220 0.352971743026902 2973 3906265
SGTC_2067 5224629 34.075 µM -0.377824306398151 0.339287153415495 no 2221 0.352780557963865 3211 2835000
SGTC_751 0833-0568 350 µM -0.378745715383513 0.338916446318986 no 2222 0.352438351015559 3160 6954252
SGTC_3119 9125183 49.47 µM -0.379503772487396 0.338611576886981 no 2223 0.352156901700497 3098 22695334
SGTC_2993 9054257 71.4286 µM -0.379698016162317 0.338533474504873 no 2224 0.352084796478188 3040 6470217 YGL055W OLE1
SGTC_2936 9038235 15.59 µM -0.381540472207009 0.33779299711824 no 2225 0.351401122879547 3036 4749415
SGTC_3260 9137109 49.47 µM -0.382291671015036 0.337491272513323 no 2226 0.351122515974744 3128 17478346
SGTC_3121 9125696 49.47 µM -0.382474640619275 0.337417797218414 no 2227 0.35105466776037 3115 1235365
SGTC_1019 4262-0212 3.4 µM -0.38319851621807 0.337127170536215 no 2228 0.350786289050911 3155 4677213
SGTC_46 0329-0187a 2.197 µM -0.384827567171567 0.336473483315741 no 2229 0.350182586717157 3169 46494817
SGTC_2096 5468907 200 µM -0.386141769197428 0.335946494965334 no 2230 0.349695838429273 3169 759785
SGTC_2749 bexarotene 57.39 µM -0.387281949999147 0.335489549337075 no 2231 0.349273743383189 3146 82146 An retinoic acid receptor inhibitor.
SGTC_2062 5245942 200 µM -0.387318937763598 0.335474729970493 no 2232 0.34926005362717 3108 1376160
SGTC_787 4152-0075 138 µM -0.387437197606215 0.335427350182673 no 2233 0.349216285106965 3116 9566539
SGTC_1524 corynanthine 62.1 µM -0.38761149838196 0.335357522849033 no 2234 0.349151779231719 3235 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist.
SGTC_1636 st007707 68.9 µM -0.387902794415913 0.335240838271314 no 2235 0.349043985047167 3287 403051
SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM -0.389689533558336 0.3345254715235 no 2236 0.348383068450302 3167 66535 A nucleotide analog.
SGTC_2686 alizarin 95.37 µM -0.390372062846231 0.334252361777434 no 2237 0.348130721512656 3126 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1
SGTC_326 k292-0812 17.5 µM -0.390963047220041 0.334015953999946 no 2238 0.347912275159301 3181 3579357
SGTC_443 clozapine 122 µM -0.391881042391363 0.333648864751041 no 2239 0.347573055466414 3161 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_558 k064-0027 21.3 µM -0.392182077145748 0.333528521178258 no 2240 0.347461842963383 3173 5088526
SGTC_2019 4016004 108 µM -0.39262031560738 0.333353358797319 no 2241 0.34729996620326 3157 45595336
SGTC_2708 st078559 56 µM -0.393198307152777 0.333122393163404 no 2242 0.347086509966253 3202 17250902
SGTC_485 niflumic acid 177 µM -0.393204949901539 0.333119739086209 no 2243 0.347084057035454 3200 4488 A COX2 inhibitor.
SGTC_3139 9095020 49.47 µM -0.393285208939672 0.333087672647691 no 2244 0.347054420734287 3010 25236292
SGTC_1682 st012968 530 nM -0.394369891867086 0.332654421685683 no 2245 0.346653984577065 3081 24207270
SGTC_316 k060-0003 58.6 µM -0.397927507598791 0.331234986726808 no 2246 0.345341811358371 3205 6152314
SGTC_1065 prochlorperazine maleate 2.48 µM -0.400192159309938 0.330332684709819 no 2247 0.3445074945737 3175 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine.
SGTC_965 1291-5240 308 µM -0.400978958069735 0.330019432005168 no 2248 0.344217807999332 3237 2834598
SGTC_2282 7944268 200 µM -0.401631897032002 0.329759564118148 no 2249 0.343977475811833 3308 2970414
SGTC_3097 9117246 49.47 µM -0.40253657269476 0.329399641520117 no 2250 0.343644589153054 3121 16423892
SGTC_178 4092-0806 87.505 µM -0.403227285301715 0.329124949857359 no 2251 0.343390514443939 3198 2169044
SGTC_1394 3474-0001 65.7 µM -0.404376675158196 0.328668049897215 no 2252 0.342967874795055 3148 5017666 YIL048W NEO1
SGTC_420 mitomycin C 81.9 mM -0.404614300652484 0.328573622058646 no 2253 0.342880522523113 3110 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_903 1134-0042 114 µM -0.405377360138449 0.328270470812251 no 2254 0.342600074999267 3125 701009
SGTC_2784 7567673 72.73 µM -0.405726218377774 0.328131912696184 no 2255 0.342471887890433 3202 3471247
SGTC_926 2268-1401 59.4 µM -0.406453024978922 0.327843318529748 no 2256 0.342204882865831 3177 2931578
SGTC_1616 st002734 56.1 µM -0.407206641563431 0.327544187419087 no 2257 0.341928112012236 3099 4026101
SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM -0.407793359353153 0.327311379628598 no 2258 0.341712694671393 3237 368090
SGTC_2387 9077560 195.08 µM -0.408017237399495 0.32722256321398 no 2259 0.341630509937442 3126 5303272
SGTC_366 0181-0206 4.31 µM -0.408281906975141 0.327117576689941 no 2260 0.341533360479972 3319 274874
SGTC_682 0kpi-0099 17 µM -0.409418368366705 0.326666931913598 no 2261 0.34111633101621 3220 1714895 YML126C ERG13
SGTC_511 blebbistatin 171 µM -0.40979732916148 0.326516717507858 no 2262 0.340977312807454 3276 3476986 A myosin inhibitor.
SGTC_1313 1220-0047 237 µM -0.409983854889387 0.326442791819144 no 2263 0.340908895522433 3177 3528706
SGTC_2701 st077767 14.721 µM -0.410257293622907 0.326334432244593 no 2264 0.340808608168039 3154 5721188
SGTC_1604 st002052 72.4 µM -0.41027136121025 0.326328857871911 no 2265 0.340803448994299 3259 6254834 YHR062C RPP1
SGTC_1481 3346-2004 36 µM -0.410667632412697 0.326171848780234 no 2266 0.340658131976001 3222 2770522
SGTC_2814 7977482 42.97 µM -0.411827136987829 0.325712611250805 no 2267 0.340233064757751 3267 6456762
SGTC_3222 9128301 49.47 µM -0.412061879896359 0.325619670290978 no 2268 0.340147034141579 3107 4911358
SGTC_1795 st049545 62.3 µM -0.413672579841278 0.32498224396048 no 2269 0.339556955502688 3231 5291882
SGTC_1672 st016598 6.51 µM -0.413871824317203 0.324903429516543 no 2270 0.339483989738985 3139 4665860 YNL267W PIK1
SGTC_2830 7992007 71.43 µM -0.41606010558237 0.324038335019165 no 2271 0.338683010818796 3008 1952075
SGTC_2208 7283366 200 µM -0.416983701520361 0.323673493931628 no 2272 0.338345164582828 3220 898663
SGTC_1285 0929-0069 65.5 µM -0.417507068544408 0.323466827401026 no 2273 0.338153777577021 3169 1206237
SGTC_3023 9089636 49.47 µM -0.418082292286524 0.323239746559585 no 2274 0.337943475630255 3250 17249241
SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM -0.419425693956544 0.32270966899692 no 2275 0.337452524698552 3158 115019
SGTC_88 0180-0332 8.668 µM -0.419976825061846 0.322492308547771 no 2276 0.337251191829293 3124 3101745
SGTC_1841 st054148 70 µM -0.4200219751613 0.322474504499422 no 2277 0.337234700179144 3206 675442
SGTC_202 3594-0513 34.79 µM -0.420074555738707 0.32245377090226 no 2278 0.337215494846261 3169 708429
SGTC_2778 tioconazole 65.09 nM -0.421305466016392 0.321968555695286 no 2279 0.336766019677702 3178 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_1049 3226-0134 66 µM -0.422599209888527 0.321458898934512 no 2280 0.336293851589054 3233 5702385
SGTC_3290 9121031 71.43 µM -0.422626357818665 0.321448207888908 no 2281 0.336283946373028 3171 17014854
SGTC_80 0159-0065 512.242 µM -0.4230383843392 0.321285967112497 no 2282 0.336133627994014 3242 1548079
SGTC_813 k007-0158 173 µM -0.424185623009225 0.320834406755503 no 2283 0.335715222503869 3195 6523916
SGTC_3156 9099931 49.47 µM -0.425824170128086 0.320189923806783 no 2284 0.335117986698591 3102 18111053
SGTC_1417 3966-0327 90.4 µM -0.426582654921813 0.319891775547305 no 2285 0.334841666723703 3212 651118
SGTC_1393 3470-5649 58.2 µM -0.426871669163634 0.319778199257056 no 2286 0.334736400837908 3196 4108395
SGTC_1624 st003710 6.25 µM -0.428190910973278 0.319259980723867 no 2287 0.334256066514063 3260 24207033
SGTC_1159 4092-0538 61.2 µM -0.428607223543657 0.319096519933499 no 2288 0.334104543892703 3178 717301
SGTC_1473 k844-0725 134 µM -0.428832981615176 0.319007893084982 no 2289 0.334022387476266 3229 54682906
SGTC_704 1310-0270 142 µM -0.429835867582499 0.318614310810768 no 2290 0.333657519894369 3195 5718033
SGTC_1663 st014140 55.4 µM -0.430508384541058 0.318350496293732 no 2291 0.333412934440907 3228 4207120
SGTC_999 SEC7.066 22.7 µM -0.430617361352906 0.318307755607891 no 2292 0.333373307690844 3138 740511 YDR170C SEC7
SGTC_572 0960-0087 17.7 µM -0.431195220145891 0.318081159919719 no 2293 0.333163214567736 3199 6796365
SGTC_1947 st076332 61.6 µM -0.431697594804825 0.317884219128954 no 2294 0.332980607873009 3283 24208416
SGTC_418 lividomycin a 100 µM -0.432153267637324 0.317705630915066 no 2295 0.33281501093523 3296 72394 An antibiotic.
SGTC_2815 7968870 71.43 µM -0.432277697578371 0.31765687145101 no 2296 0.332769797278124 3161 2977326 YHR190W ERG9
SGTC_1383 3049-0032 20.7 µM -0.432767764855818 0.317464863082665 no 2297 0.332591746962081 3294 712864
SGTC_1704 st028805 70.8 µM -0.434604653127815 0.316745607504974 no 2298 0.331924708471564 3227 2876101
SGTC_249 wiskostatin 11.211 µM -0.435435501660602 0.316420506003214 no 2299 0.331623172982724 3284 2775510 A n-wasp and actin depolymerizer.
SGTC_2455 5377712 9.75 µM -0.435585956536092 0.31636164989405 no 2300 0.331568580844869 3231 2243908
SGTC_1092 toremifene 6.32 µM -0.435820763153089 0.31626980570834 no 2301 0.331483389058504 3177 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_1893 st059353 36.1 µM -0.436120479903465 0.316152588507191 no 2302 0.331374659450956 3225 3112488
SGTC_327 1273-0057 3.96 µM -0.438396439643631 0.315263079519538 no 2303 0.33054946346394 3183 3108138
SGTC_548 1436-0017 110 µM -0.439442477949757 0.314854616890608 no 2304 0.330170476598056 3323 9677137
SGTC_2816 7982706 58.44 µM -0.44029622954663 0.314521407154203 no 2305 0.329861285600991 3252 2981853
SGTC_217 ketoconazole 989 nM -0.440682332281015 0.314370765135462 no 2306 0.329721494448095 3241 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4
SGTC_1157 4092-0394 27.6 µM -0.441230794224655 0.314156830112553 no 2307 0.329522960917435 3362 3659885
SGTC_725 1497-0963 19 µM -0.441803847492811 0.31393336959612 no 2308 0.329315577080795 3282 3549977
SGTC_3342 9147791 14.508 µM -0.442587893482098 0.313627743586201 no 2309 0.329031921564624 3186 1838168
SGTC_889 0919-1524 82.7 µM -0.443094049169516 0.313430508855254 no 2310 0.328848854657288 3248 3905452
SGTC_1838 st055369 84.5 µM -0.443314499914532 0.313344622030014 no 2311 0.328769134637625 3227 676036
SGTC_123 0083-0120 66.675 µM -0.443405508668439 0.313309168295117 no 2312 0.328736226067351 3200 16001701
SGTC_1036 k216-0215 33.5 µM -0.443781508472628 0.313162710596038 no 2313 0.328600279423483 3172 622330
SGTC_1139 k015-0024 46.9 µM -0.444165774253641 0.31301306361912 no 2314 0.328461367565611 3290 2766652
SGTC_19 0279-0214 38.434 µM -0.444946260762169 0.312709208804151 no 2315 0.328179295137789 3209 3566274 YBR002C RER2
SGTC_2501 sodium tetradecyl sulfate 13.37 µM -0.444991027770856 0.312691784209175 no 2316 0.328163119045389 3146 23665772 A membrane-active detergent.
SGTC_3076 9116187 49.47 µM -0.445598697784254 0.312455303149003 no 2317 0.327943575699069 3260 27241210
SGTC_2219 9098279 200 µM -0.44592086855212 0.312329958381192 no 2318 0.327827203657803 3274 902349
SGTC_2990 9074105 71.4286 µM -0.446369744913525 0.312155353344316 no 2319 0.327665091872796 3252 6502001
SGTC_617 3770-0098 35 µM -0.446819447093513 0.311980469379891 no 2320 0.327502714411191 3214 5962639
SGTC_2399 5884133 200 µM -0.447685991780792 0.311643599715961 no 2321 0.327189916408237 3191 722445
SGTC_1012 4112-3522 18 µM -0.449006223137095 0.311130662119968 no 2322 0.326713583706703 3326 3112398
SGTC_1015 4130-4525 82 µM -0.449590326135706 0.310903842758535 no 2323 0.326502932372865 3199 1363237
SGTC_179 1273-0063 6.77 µM -0.452558668660086 0.309752284917967 no 2324 0.325433283115694 3170 3108139
SGTC_1504 k297-0033 30 µM -0.453393307328426 0.30942882520076 no 2325 0.325132777416486 3126 4388117
SGTC_350 k064-0020 19.8 µM -0.454199522386284 0.30911652102856 no 2326 0.324842613387492 3349 2790705
SGTC_1184 1269-1718 139 µM -0.454396959268042 0.30904006075718 no 2327 0.324771570271024 3332 5403821
SGTC_718 1130-0073 349 µM -0.454907334062244 0.308842449116354 no 2328 0.324587953188236 3372 6740020
SGTC_272 doxorubicin 8.13 µM -0.454974621726795 0.308816400181771 no 2329 0.32456374834494 3278 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_2323 6148992 148.28 µM -0.456194263369121 0.308344409638281 no 2330 0.324125145121951 3189 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42
SGTC_977 1348-1378 135 µM -0.45739731923552 0.307879147816611 no 2331 0.323692745428971 3175 X977
SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM -0.457680762425609 0.307769575787936 no 2332 0.323590905506537 3213 2333 A French combination drug.
SGTC_1758 st042942 75.2445 µM -0.457696033041184 0.307763673037488 no 2333 0.323585419214835 3287 669317
SGTC_2246 7293507 91.5585 µM -0.463276912556843 0.305609764739786 no 2334 0.321582946184896 3298 887656
SGTC_2181 6316240 54.2555 µM -0.463325921644094 0.305590879579564 no 2335 0.32156538408614 3286 12779990
SGTC_2589 lobaric acid 100 µM -0.464112631596526 0.305287799600845 no 2336 0.3212835261152 3199 73157 A novel microtubule depolymerizer.
SGTC_1803 st050068 52.4 µM -0.464276590267665 0.305224651325704 no 2337 0.321224796886391 3347 3984059 YIL048W | YNL267W NEO1 | PIK1
SGTC_3299 9121982 43.1275 µM -0.464341775182332 0.305199547128099 no 2338 0.321201449196853 3233 17594604 YPL160W CDC60
SGTC_767 0929-0023 86 µM -0.464423042296335 0.305168250592105 no 2339 0.321172342234878 3336 1204563
SGTC_2347 9049783 174.81 µM -0.464428522246857 0.305166140275963 no 2340 0.321170379552917 3342 6467988 YPL169C MEX67
SGTC_435 c-PAF 6.7 µM -0.465898920257589 0.304600127668391 no 2341 0.320643927030773 3306 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase
SGTC_3127 9126946 49.47 µM -0.467065943120789 0.304151228473946 no 2342 0.320226349714266 3243 27243249
SGTC_423 5-fluorouracil 457 µM -0.470632283317721 0.302781254498181 no 2343 0.318951674741366 3120 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_2959 9079155 11 µM -0.470763810884323 0.302730782373433 no 2344 0.318904705187484 3350 16189457
SGTC_148 3253-0744 288.01 µM -0.47077973504736 0.302724671922797 no 2345 0.318899018737897 3322 6893655
SGTC_2725 haloperidol 53.21 µM -0.47078681119774 0.302721956666419 no 2346 0.318896491888953 3206 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_1607 st000305 50.6 µM -0.471182691667036 0.302570067020613 no 2347 0.318755138866856 3326 5457690
SGTC_708 3448-5400 146 µM -0.471984109167614 0.302262687358739 no 2348 0.318469065578873 3322 3462195
SGTC_206 4546-0025 72.014 µM -0.473605277838365 0.301641325072197 no 2349 0.317890705562481 3325 6620745 YIL048W NEO1
SGTC_960 1222-0186 7.7 µM -0.473852387994015 0.301546663054216 no 2350 0.317802586738802 3338 3126296
SGTC_2176 5809774 33.9695 µM -0.474150728154603 0.301432393853293 no 2351 0.317696213179908 3310 2870539
SGTC_687 k029-0044 34.9 µM -0.474277906545556 0.30138368835814 no 2352 0.317650872138625 3340 5829338
SGTC_487 nimodipine 119 µM -0.47589497602735 0.300764708596703 no 2353 0.31707460078644 3246 4497 L-type voltage-gated calcium channels inhibitor
SGTC_1424 4048-1941 275 µM -0.475983790825112 0.300730728806205 no 2354 0.317042962891921 3357 X1424
SGTC_1345 1488-0192 31.4 µM -0.477501213502618 0.300150443576996 no 2355 0.316502628466748 3352 658348
SGTC_3114 9122766 49.47 µM -0.479394995871319 0.299426943947771 no 2356 0.315828826386284 3287 17176985
SGTC_1293 1000-1278 195 µM -0.480573145474278 0.298977243655946 no 2357 0.315409952694955 3367 678847
SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM -0.481110991258241 0.298772049680814 no 2358 0.315218808367784 3289 676296 Flavone; oxidizing agent.
SGTC_2362 9071156 126 µM -0.483921489954206 0.297700856748274 no 2359 0.314220794200853 3371 653133
SGTC_885 0865-0106 16.8 µM -0.484551192908002 0.297461092385084 no 2360 0.313997371109793 3235 2793380
SGTC_390 dec-rvkr-cmk 16.7 µM -0.486353102780415 0.296775488694256 no 2361 0.31335841747606 3324 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1
SGTC_25 0118-0223 35.662 µM -0.486646364293268 0.296663974916938 no 2362 0.313254480448141 3389 5333628
SGTC_1971 st069429 63.5 µM -0.486741740706936 0.296627711817894 no 2363 0.313220680568964 3330 1246522 YGL099W LSG1
SGTC_160 3453-0671 289.699 µM -0.487489003204577 0.296343665182406 no 2364 0.312955916987566 3259 5322268
SGTC_2406 ethylparaben 405.7 µM -0.487995436832791 0.296151232446883 no 2365 0.312776536622273 3103 8434 A possible steroid mimic.
SGTC_2950 9072895 21.46 µM -0.488455625220802 0.295976421537331 no 2366 0.312613574903299 3345 17332245
SGTC_1052 3253-3998 198 µM -0.488697748313899 0.295884465710303 no 2367 0.31252784907835 3250 5450317
SGTC_3193 9111931 49.47 µM -0.490428131983039 0.295227666321468 no 2368 0.311915486918024 3247 17087244
SGTC_1786 berberine 21.6 µM -0.491114289782318 0.294967408290836 no 2369 0.311672807600563 3327 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_311 1315-0136 58 µM -0.491398895717668 0.294859488958143 no 2370 0.311572172562816 3413 6759207
SGTC_452 diindolylmethane 8 µM -0.492237495888981 0.294541607179682 no 2371 0.311275730168265 3345 3071 Inhibits expression of several cancer promoting factors.
SGTC_1707 st032323 6.317 µM -0.493056469514347 0.294231317804094 no 2372 0.310986343773645 3325 3132057 YMR211W DML1
SGTC_154 3389-1638 511.116 µM -0.495547139677027 0.293288592080531 no 2373 0.310106977741925 3296 5238686
SGTC_122 0236-0016 402.397 µM -0.496041650800483 0.293101584920347 no 2374 0.309932512582353 3343 6808838
SGTC_2330 7979373 200 µM -0.496198260655068 0.293042371972867 no 2375 0.309877269027975 3249 1863007
SGTC_3229 9132204 49.47 µM -0.496848468694406 0.2927965928217 no 2376 0.309647956436761 3268 17682924
SGTC_3070 9117005 49.47 µM -0.49916541369963 0.291921564911867 no 2377 0.308831428905341 3376 8779016
SGTC_3169 9102970 49.47 µM -0.499910869461284 0.291640291899842 no 2378 0.308568919197417 3377 17027839
SGTC_1218 1348-1416 30.7 µM -0.501080851970869 0.291199092725613 no 2379 0.308157111103506 3324 6787668
SGTC_379 3970-0972 5.9 µM -0.501637992551821 0.290989105185432 no 2380 0.307961094685796 3344 2898042 YBL034C STU1
SGTC_2572 astragaloside iv 100 µM -0.502098635435632 0.290815541292848 no 2381 0.307799070009706 3389 45006101 An anti-inflammatory agent.
SGTC_2184 6075246 200 µM -0.503641880445688 0.290234420802234 no 2382 0.307256528405441 3336 2267320
SGTC_1097 itavastatin 7.23 µM -0.504636521174012 0.289860169885394 no 2383 0.3069070768769 3334 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49
SGTC_1901 st060216 58.6 µM -0.505372956127263 0.289583219319757 no 2384 0.306648454893967 3278 688792
SGTC_1992 st073643 23.3 µM -0.506033588580546 0.289334881509553 no 2385 0.306416535193714 3322 3161292
SGTC_2657 nystatin 74.44 µM -0.506965556883743 0.288984716326209 no 2386 0.30608949295401 3367 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_84 0443-0269 128.823 µM -0.508397838293127 0.288446959245224 no 2387 0.305587184242692 3371 6150058
SGTC_607 4491-0986 66.8 µM -0.509257250918874 0.28812451513419 no 2388 0.305285959128923 3415 698981 YDR232W HEM1
SGTC_467 ro 31-8220 72.8 µM -0.509342903921452 0.28809238819806 no 2389 0.305255944873107 3290 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7
SGTC_280 3448-3607 3.04 µM -0.510013055897275 0.287841084342195 no 2390 0.305021157537962 3382 626179
SGTC_3016 9080866 49.47 µM -0.510582535901623 0.287627613412624 no 2391 0.304821703622804 3279 17066299
SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM -0.51117093343956 0.287407129830253 no 2392 0.30461568496398 3283 4174840
SGTC_1323 1348-1351 11.2 µM -0.51129085778293 0.287362201741068 no 2393 0.304573702835134 3303 6989654
SGTC_1156 4092-0367 4.88 µM -0.511649962532037 0.287227687710541 no 2394 0.304448005791164 3327 1357585
SGTC_1421 4029-0249 71.4 µM -0.51203240984705 0.287084462762872 no 2395 0.304314163567939 3433 2894095
SGTC_1140 3229-1848 2.98 µM -0.512348714179366 0.286966033647313 no 2396 0.304203488708909 3381 2849525
SGTC_648 0375-0473 33.3 µM -0.512618342868596 0.286865098872983 no 2397 0.304109159812957 3314 1713139
SGTC_313 3474-0040 5.03 µM -0.513905106770774 0.286383634140387 no 2398 0.303659168463355 3306 1043375 YIL048W NEO1
SGTC_3158 9100007 49.47 µM -0.514216782110869 0.286267073206951 no 2399 0.303550217902855 3281 19297233
SGTC_2956 9076196 2.52 µM -0.514378159471184 0.286206729849197 no 2400 0.303493813004946 3435 16423868
SGTC_623 k072-0108 16.9 µM -0.515248514769775 0.285881384669502 no 2401 0.303189685640693 3351 5382803
SGTC_935 2996-0153 430 µM -0.515745299470201 0.285695761773925 no 2402 0.303016155785171 3418 23738523
SGTC_1343 1487-0095 224 µM -0.517003721398476 0.285225810978626 no 2403 0.302576780514762 3409 4560101 YGL055W OLE1
SGTC_1552 6-methylflavone 10.6 µM -0.517220486080692 0.285144898596402 no 2404 0.302501126436164 3397 689013
SGTC_495 decylubiquinone 155 µM -0.517490118203894 0.285044267501463 no 2405 0.302407032676016 3356 2971 A Co-enzyme Q analog. A free radical scavenger.
SGTC_1316 1272-0050 65.9 µM -0.51814856870384 0.284798594252431 no 2406 0.302177307808477 3385 7340392
SGTC_2961 9083290 32.55 µM -0.518636592726251 0.2846165737315 no 2407 0.302007093095681 3384 17741490
SGTC_481 bay k-8644 50 µM -0.518820282103275 0.284548076667144 no 2408 0.301943036433864 3325 2303 A calcium channel antagonist.
SGTC_2391 6285546 200 µM -0.518893903786752 0.284520625633874 no 2409 0.301917364592614 3298 846083
SGTC_3072 9116419 49.47 µM -0.519643828905824 0.284241076034305 no 2410 0.301655921998976 3343 17170162
SGTC_1190 1486-1332 13 µM -0.520636893231044 0.283871093624715 no 2411 0.30130987178908 3366 4150046
SGTC_1404 3909-7820 48.3 µM -0.520899729332044 0.283773208316226 no 2412 0.301218311990476 3405 23741373
SGTC_2809 7964133 12.99 µM -0.521484806902746 0.283555372025294 no 2413 0.30101454335627 3321 1253665
SGTC_3051 9093778 49.47 µM -0.522111969579736 0.283321955608432 no 2414 0.300796186509609 3355 17217378
SGTC_770 0389-1121 67.2 µM -0.522641572675707 0.28312492054545 no 2415 0.300611852282181 3477 6753108
SGTC_2857 9024691 58.44 µM -0.523679021805245 0.282739135650049 no 2416 0.300250904498239 3388 16478292
SGTC_1866 st057638 64 µM -0.524147130088283 0.282565148055505 no 2417 0.300088105117823 3334 688802
SGTC_3008 9078912 71.4286 µM -0.525283381845671 0.282143037541293 no 2418 0.299693104009793 3343 16648731
SGTC_2741 miltefosine 3.04 µM -0.526173273627587 0.281812660350705 no 2419 0.299383910858221 3306 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis.
SGTC_3272 9137413 49.47 µM -0.526218794609472 0.281795765450926 no 2420 0.299368098470061 3361 17614870
SGTC_2859 9028643 45.46 µM -0.526288762308343 0.281769798218178 no 2421 0.299343794890712 3360 17151580
SGTC_1416 3966-0321 25.3 µM -0.526530690587351 0.281680019848501 no 2422 0.299259766966098 3369 582530 YLR208W SEC13
SGTC_1358 1509-0022 2.48 µM -0.528430379500099 0.280975534588723 no 2423 0.29860032832952 3391 3258434
SGTC_3271 9137798 49.47 µM -0.528511855483115 0.280945338889493 no 2424 0.298572060372695 3385 6498326
SGTC_758 0868-0029 16 µM -0.529595027139835 0.280544055260407 no 2425 0.298196371477209 3434 762687
SGTC_347 4534-1311 26.2 µM -0.531040376690466 0.280009027633876 no 2426 0.297695399860305 3387 2862016
SGTC_1983 st071813 46.9 µM -0.531861339556403 0.279705350779619 no 2427 0.297411017600749 3386 11838595
SGTC_1557 sumaresinolic acid 42.3 µM -0.534650718023224 0.278674746200429 no 2428 0.296445702751362 3352 9982268 A natural terpine and antifungal of unknown mechanisn.
SGTC_2773 thioridazine 9.09 µM -0.535197005471841 0.278473123566293 no 2429 0.296256818388922 3423 5452 An antipsychotic.
SGTC_1635 st007035 42.4 µM -0.536021321328273 0.278169021384477 no 2430 0.295971907450115 3419 3716403
SGTC_802 4112-3352 742 µM -0.53611859674181 0.278133145747471 no 2431 0.295938294136195 3449 704594
SGTC_2994 9053520 71.4286 µM -0.537061671264532 0.277785452404268 no 2432 0.295612507635415 3403 4647384
SGTC_466 geldanamycin 89.2 µM -0.53721137264811 0.277730279923437 no 2433 0.2955608082353 3322 5288382 HSP90 inhibitor.
SGTC_1836 st055642 81 µM -0.537477101336869 0.277632358734302 no 2434 0.295469049024565 3332 8571
SGTC_1849 st056239 19.2 µM -0.537588306996025 0.277591384385655 no 2435 0.295430652304745 3309 5393181
SGTC_1701 st028638 40.4 µM -0.537598049757234 0.277587794751432 no 2436 0.29542728846594 3437 3490878
SGTC_1098 clofazimine 15.1 µM -0.537978620507309 0.277447594572401 no 2437 0.295295904323712 3454 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2
SGTC_625 k213-0058 121 µM -0.538086461894469 0.277407872691068 no 2438 0.295258679216117 3428 3655420
SGTC_1567 st069303 68.4 µM -0.538326010851246 0.277319648098952 no 2439 0.295175998508187 3421 5581319
SGTC_1068 loratadine 26.9 µM -0.538433027391036 0.277280238917635 no 2440 0.295139065022411 3375 3957 A H1 histamine antagonist.
SGTC_1722 st034304 3.6505 µM -0.539215804085826 0.276992062227435 no 2441 0.294868978317525 3340 4036148 YLR033W RSC58
SGTC_1877 wortmannin 25 µM -0.540626618512026 0.276473046038522 no 2442 0.294382483438854 3466 312145 A covalent inhibitor of PI 3-kinase.
SGTC_927 2425-1185 123 µM -0.540988958413534 0.276339823957712 no 2443 0.294257596647643 3299 730375
SGTC_2265 7929201 200 µM -0.541955478622162 0.27598461606336 no 2444 0.293924588297529 3299 1265108
SGTC_251 melphalan 456.522 µM -0.542863175644617 0.275651230711436 no 2445 0.29361200588619 3412 460612 A DNA alkylator.
SGTC_285 1486-1325 46 µM -0.543069164494474 0.27557560125009 no 2446 0.293541091212519 3453 22310230
SGTC_1074 carmofur 3.8 µM -0.543129264934472 0.275553537105458 no 2447 0.293520402251979 3439 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_2439 5492030 7.2 µM -0.543614198596263 0.275375539478161 no 2448 0.293353493520952 3403 5722370
SGTC_176 1486-1328 72.834 µM -0.544762137428125 0.274954407695265 no 2449 0.292958561227923 3407 22310231
SGTC_2558 carylophyllene oxide 100 µM -0.545406602155335 0.274718119124439 no 2450 0.292736950345628 3469 6708694 An oxygenated terpenoid and antifungal agent.
SGTC_975 1335-0046 28.5 µM -0.545552551068883 0.274664621865186 no 2451 0.292686773978817 3370 16486740
SGTC_1390 3413-2614 145 µM -0.546454670493203 0.274334066007034 no 2452 0.292376719387726 3413 3421432
SGTC_2796 7949634 45.45 µM -0.547707812462878 0.273875214121199 no 2453 0.291946273452127 3406 2971588
SGTC_2888 9058547 12.99 µM -0.547881615451638 0.27381160419715 no 2454 0.291886596591514 3362 16476514
SGTC_2113 5491891 107.031 µM -0.548433095266197 0.273609817216312 no 2455 0.291697278532637 3396 789979
SGTC_1181 1222-0449 220 µM -0.549417324063573 0.27324986992647 no 2456 0.291359543931479 3510 658318
SGTC_1911 st060208 74.3 µM -0.549879171622016 0.273081046221327 no 2457 0.29120112551489 3429 688783
SGTC_244 nsc-207895 1.295 µM -0.550306777647917 0.272924785266699 no 2458 0.291054488155998 3340 42640
SGTC_1869 3',7'-dimethoxyflavone 40.3 µM -0.552137491834769 0.272256285286537 no 2459 0.290427078375603 3390 688664
SGTC_2369 9071472 200 µM -0.552487624414155 0.272128524316876 no 2460 0.290307155508338 3448 17296037
SGTC_2881 9058953 51.95 µM -0.552717199751766 0.272044770036286 no 2461 0.290228536933199 3369 17122249
SGTC_395 anisomycin 6.25 µM -0.553062483640048 0.271918826798019 no 2462 0.290110312497186 3400 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_1919 st067113 52.3 µM -0.553819928537279 0.271642648348763 no 2463 0.289851044138884 3445 1268243
SGTC_2628 lathosterol 100 µM -0.554190444213814 0.271507602349808 no 2464 0.2897242586816 3491 6710616
SGTC_2861 9024595 19.48 µM -0.55475626247481 0.271301436776572 no 2465 0.289530693552416 3347 16482810
SGTC_277 nystatin 15.5 µM -0.55490836395039 0.271246029308369 no 2466 0.289478670344825 3327 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_130 0136-0219 337.655 µM -0.555027382782479 0.271202677107291 no 2467 0.289437965442738 3408 234244
SGTC_2402 5553605 200 µM -0.556766142051447 0.270569734145564 no 2468 0.288843609809974 3508 6758546
SGTC_451 chloral hydrate 100 µM -0.557106591399472 0.270445890251826 no 2469 0.288727302168518 3459 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1
SGTC_332 4112-0506 40.9 µM -0.557353687279393 0.27035602291895 no 2470 0.288642900667158 3425 2790355
SGTC_2435 5706476 10.6 µM -0.559853525636083 0.269447686520417 no 2471 0.287789675362634 3478 5725375
SGTC_604 1000-0114 314 µM -0.560011383840264 0.269390378862618 no 2472 0.287735836450622 3487 1572745
SGTC_125 0133-0007 11.75 µM -0.561324867428755 0.268913778721157 no 2473 0.287288046098659 3516 26541
SGTC_3234 9132280 49.47 µM -0.561502853169761 0.268849228825556 no 2474 0.287227392913868 3463 17612295
SGTC_2536 dehydroabietamide 32.04 µM -0.562017718660684 0.26866254693763 no 2475 0.287051973486583 3489 3983547
SGTC_2588 indole-3-carbinol 100 µM -0.56392937120504 0.267969983059157 no 2476 0.286401100114685 3479 3712 Induces cell cycle arrest.
SGTC_1740 st038286 13.222 µM -0.564038305825347 0.267930544722813 no 2477 0.286364031506533 3495 716786
SGTC_1904 st060225 78 µM -0.564622032902389 0.267719263876244 no 2478 0.286165437866548 3465 66595
SGTC_2698 st077697 67.5 µM -0.566760915263029 0.266945810489725 no 2479 0.285438314158482 3383 3154499
SGTC_2760 etidronate 98.04 µM -0.567176079260277 0.266795811591034 no 2480 0.285297279108667 3407 3305 A chelator and antioxidant.
SGTC_2011 4012611 177 µM -0.569100461823585 0.266101088227871 no 2481 0.284643982491338 3412 2049887
SGTC_2255 7941087 197.44 µM -0.569801242351947 0.265848326455468 no 2482 0.284406256415051 3513 935561
SGTC_2954 9074818 52.69 µM -0.570700482754605 0.265524161311634 no 2483 0.284101345750422 3483 16648742
SGTC_859 0439-0102 54.6 µM -0.571040340950835 0.265401698831012 no 2484 0.283986148784471 3512 610143
SGTC_164 4100-3994 89.624 µM -0.571788910937105 0.265132064706825 no 2485 0.283732495372549 3530 4615967
SGTC_1162 k048-0130 20.1 µM -0.57492147746502 0.264005228864505 no 2486 0.282672201881129 3423 6797406
SGTC_3153 9100258 49.47 µM -0.575112553219762 0.263936574821971 no 2487 0.282607589299563 3389 25236848
SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM -0.575724638644172 0.263716712133486 no 2488 0.282400659411429 3506 7104
SGTC_2890 9046729 58.44 µM -0.576885888041991 0.263299845189943 no 2489 0.282008272126998 3361 903329
SGTC_1534 6-azauridine 81.6 µM -0.576939331503992 0.26328066808392 no 2490 0.281990219852332 3455 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1
SGTC_1782 st039423 80.636 µM -0.577405128582588 0.263113556425414 no 2491 0.281832905247172 3387 2068169
SGTC_2115 tiliquinol 12.7705 µM -0.578223144775334 0.262820212123403 no 2492 0.281556737353303 3420 71208 A bioactive hydroxyquinoline.
SGTC_1069 diphenylcyclopropenone 8.49 µM -0.578657761074112 0.262664424822377 no 2493 0.281410061018845 3461 65057 A dermal irritant. YDR527W RBA50
SGTC_150 3970-0969 77.2 µM -0.578763917132899 0.262626380586437 no 2494 0.281374240581254 3488 6615640
SGTC_1632 st005650 90 µM -0.579465800862328 0.26237491028621 no 2495 0.281137458032084 3451 2759605
SGTC_2955 9076254 12.21 µM -0.580878635235105 0.26186909537126 no 2496 0.280661126232467 3430 16459619
SGTC_2026 5148700 152 µM -0.582697981626464 0.261218480770691 no 2497 0.280048316103313 3437 79838
SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM -0.583162506904789 0.261052495571759 no 2498 0.279891954139048 3494 6708760
SGTC_2513 baicalein 25.65 µM -0.584378695017872 0.260618181507762 no 2499 0.279482778656089 3446 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2
SGTC_364 0083-0097 67.7 µM -0.585221324353915 0.260317487635139 no 2500 0.279199454098619 3510 5207356
SGTC_1565 sinapyl alcohol 95.1 µM -0.585710193514467 0.260143115718542 no 2501 0.279035141406594 3482 5280507 A phenol propionate derived from cinnamic acid.
SGTC_1289 0976-0073 69.1 µM -0.586564080210803 0.259838692292234 no 2502 0.278748256364261 3524 3391136
SGTC_1937 st074714 47.2 µM -0.587343800480702 0.259560870939217 no 2503 0.278486414902409 3377 17250970
SGTC_1982 st072467 71.9 µM -0.589804568321616 0.258685084151894 no 2504 0.277660839808264 3385 3163533
SGTC_1705 st027868 56.3335 µM -0.591825180905084 0.25796709398469 no 2505 0.276983829667623 3506 292948
SGTC_2806 7952793 58.44 µM -0.592479094073433 0.257734958715064 no 2506 0.276764908007214 3496 2972490
SGTC_1203 3992-3522 103 µM -0.592615675341702 0.257686486873565 no 2507 0.276719193071101 3673 5322312
SGTC_727 3032-0951 202 µM -0.592657808042439 0.257671535195697 no 2508 0.276705091637138 3446 3652836
SGTC_3283 9109332 35.8195 µM -0.595331309593042 0.256723708654853 no 2509 0.275811015585517 3411 17027281
SGTC_3256 9138902 49.47 µM -0.595607815869946 0.256625783590973 no 2510 0.275718627041666 3506 17228773
SGTC_699 0375-0592 111 µM -0.596851647971713 0.256185519484709 no 2511 0.275303215881813 3548 762578
SGTC_2903 5923464 63.88 µM -0.597415347110765 0.255986123528298 no 2512 0.275115054893144 3529 2876576
SGTC_1245 0418-0076 17.2 µM -0.597449282125465 0.255974122360644 no 2513 0.27510372951405 3506 6790114
SGTC_835 0312-0010 67.2 µM -0.597624359892846 0.255912210516117 no 2514 0.275045303186645 3473 1626196
SGTC_121 0557-0495 61.343 µM -0.597754999879543 0.255866018065252 no 2515 0.275001710459124 3558 3104427
SGTC_324 1315-0088 19.6 µM -0.598042681724181 0.255764313179428 no 2516 0.274905727072927 3487 6787421
SGTC_3071 9117417 49.47 µM -0.600581005358039 0.254867848711376 no 2517 0.274059546223043 3421 45595590 YGL055W OLE1
SGTC_1835 st008666 49.2 µM -0.601217628296918 0.254643269642709 no 2518 0.273847522321987 3444 690455
SGTC_1094 duloxetine 25.4 µM -0.602861720540178 0.254063769225872 no 2519 0.273300341568327 3508 60834 A selective serotonin reuptake inhibitor.
SGTC_991 3996-0057 64.7 µM -0.602876709620021 0.254058489143308 no 2520 0.273295355449849 3500 715343
SGTC_3303 9125618 40.5795 µM -0.603486891768119 0.253843594067271 no 2521 0.273092416573775 3502 22695467
SGTC_858 0438-0351 2.77 µM -0.606785392593581 0.252683576004406 no 2522 0.271996671708671 3509 2799119
SGTC_2469 5655019 90.81 µM -0.607208285622415 0.252535054988832 no 2523 0.271856347132442 3576 2788239
SGTC_2642 cholecalciferol 100 µM -0.607832910468902 0.252315769456409 no 2524 0.271649149715895 3506 9821465 A vitamin D precursor, similar to steriods.
SGTC_2928 9011484 9.79 µM -0.607917393918514 0.252286117765255 no 2525 0.271621131327616 3516 2994751
SGTC_124 0136-0217 7.121 µM -0.609238863013593 0.251822552615992 no 2526 0.271183062035393 3633 3976905
SGTC_2732 terfenadine 20 µM -0.611440428449527 0.251051253580196 no 2527 0.270454022438987 3514 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.
SGTC_3282 9108498 15.4605 µM -0.612471274184376 0.250690535968197 no 2528 0.270112998968535 3494 16459645
SGTC_3002 9075603 71.4286 µM -0.61321244900581 0.250431350875748 no 2529 0.269867937173672 3524 20105405
SGTC_830 4076-0286 57.8 µM -0.613556408664533 0.250311118184934 no 2530 0.269754248291449 3580 6866659
SGTC_635 k038-0028 24.7 µM -0.614109115430229 0.250117981094422 no 2531 0.269571612542036 3514 4035102
SGTC_429 1112-0049 25.5 µM -0.614786435460798 0.249881407152463 no 2532 0.26934788425742 3441 2836170
SGTC_1747 st037496 66.6 µM -0.615340170049729 0.249688087341226 no 2533 0.269165047171356 3520 723305
SGTC_1583 clindamycin 39.6 µM -0.615533708574421 0.249620537912066 no 2534 0.269101157562058 3473 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis.
SGTC_2882 9058044 58.44 µM -0.615601378730254 0.24959692175049 no 2535 0.269078820550376 3507 18076804
SGTC_482 fipronil 114 µM -0.616394900874806 0.249320079584179 no 2536 0.26881695897041 3570 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels.
SGTC_428 3448-4153 16.5 µM -0.616501992911225 0.249282730069003 no 2537 0.268781628501243 3488 3834874
SGTC_1930 st074634 34.3 µM -0.61703945532613 0.249095329131444 no 2538 0.268604350836978 3527 684253 YOR116C RPO31
SGTC_912 3474-0017 2.18 µM -0.618158628656881 0.248705339446187 no 2539 0.268235389175431 3573 3360550
SGTC_1977 st070720 65.3 µM -0.6182136275951 0.248686182776783 no 2540 0.268217264064843 3547 682188
SGTC_2066 5222451 176 µM -0.618530678402922 0.248575766196056 no 2541 0.268112790774652 3549 2281147
SGTC_3058 9093861 49.47 µM -0.618576783713334 0.248559711668241 no 2542 0.268097600046612 3586 17217477
SGTC_194 1486-1323 56.904 µM -0.618694471844704 0.24851873348431 no 2543 0.268058826252162 3522 5178754
SGTC_354 2783-3500 4.88 µM -0.618773194706151 0.248491324744092 no 2544 0.2680328916183 3498 6740761
SGTC_1757 st041620 31.8375 µM -0.620191993467841 0.247997621395538 no 2545 0.267565696060642 3541 5289815
SGTC_2803 7707263 71.43 µM -0.620923627875315 0.247743237225258 no 2546 0.267324937068445 3500 2199229
SGTC_1489 4065-0444 182 µM -0.62106121987813 0.247695413017353 no 2547 0.267279671870689 3528 2877968
SGTC_2485 5633444 17.78 µM -0.621236884729332 0.247634362620434 no 2548 0.267221887038721 3532 5724239
SGTC_1530 rhein 70.4 µM -0.621476804237954 0.247550994206645 no 2549 0.267142975868869 3579 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death.
SGTC_2704 st078022 71.1 µM -0.623328812339243 0.246907954229742 no 2550 0.26653423386383 3586 54697681
SGTC_419 nsc-638432 893 µM -0.624385337350287 0.246541516613008 no 2551 0.266187276075967 3514 368090
SGTC_3191 9110352 49.47 µM -0.625618780387412 0.246114086892657 no 2552 0.265782508750741 3548 17122424
SGTC_611 3453-1652 23.7 µM -0.62585002785901 0.246033996090845 no 2553 0.265706657201102 3572 1560575
SGTC_3166 9102297 49.47 µM -0.627332043093841 0.245521043509734 no 2554 0.265220801662492 3533 25237072
SGTC_2886 9058944 51.95 µM -0.627782070571171 0.245365394565642 no 2555 0.26507335652262 3410 4949929
SGTC_23 0213-0011 39.996 µM -0.629044339516684 0.244929102518382 no 2556 0.264660014257262 3594 627608
SGTC_1210 3013-0140 750 nM -0.631119384835274 0.244212789665125 no 2557 0.263981233588233 3595 905973
SGTC_2072 5231554 129 µM -0.631656020202395 0.244027725258645 no 2558 0.26380583604212 3638 789545
SGTC_13 0199-0087 65 µM -0.631848063896535 0.243961515335617 no 2559 0.263743081618947 3579 4589825
SGTC_3183 9108214 49.47 µM -0.632407049637529 0.243768851852109 no 2560 0.26356046430188 3499 4974831
SGTC_580 1123-0028 41 µM -0.632432639629166 0.243760033813716 no 2561 0.263552105748594 3634 1677248 YPR107C YTH1
SGTC_1429 4049-0205 9.46 µM -0.63475203815245 0.242961509331898 no 2562 0.262795074236237 3602 22774478
SGTC_3026 9090633 49.47 µM -0.635181016147108 0.242813975646772 no 2563 0.262655181516674 3544 25236842
SGTC_1545 lovastatin 49.4 µM -0.636907130380377 0.242220822500297 no 2564 0.262092668983753 3588 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12
SGTC_2460 5552655 174.22 µM -0.636986825252623 0.242193455539721 no 2565 0.262066712641414 3571 5401989
SGTC_2738 aclarubicin 5.55 µM -0.637073806001133 0.242163588545991 no 2566 0.26203838481838 3481 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31
SGTC_1724 st037281 8.293 µM -0.638487915281735 0.241678299343024 no 2567 0.261578059095343 3592 574124 YDL195W SEC31
SGTC_353 1988-1175 58.3 µM -0.640459250726684 0.241002665040718 no 2568 0.260937036553931 3460 2788357
SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM -0.640550629823093 0.240971371682033 no 2569 0.260907342259367 3536 4620898
SGTC_464 bw-b 70c 158 µM -0.640664314905357 0.240932442580312 no 2570 0.260870401900514 3607 5353454
SGTC_3291 9121177 71.43 µM -0.641874830126763 0.240518138926044 no 2571 0.260477229006381 3519 17015612
SGTC_2488 5268135 45.7 µM -0.641905945624688 0.240507494639417 no 2572 0.260467126779808 3572 1270356 YLR208W SEC13
SGTC_3240 9133527 49.47 µM -0.642660384842944 0.240249487396238 no 2573 0.260222245789989 3572 17617455
SGTC_1966 st070145 16.1 µM -0.645311234776014 0.239344132423136 no 2574 0.259362756786356 3544 3748532
SGTC_3340 9146634 11.102 µM -0.645734410522939 0.239199776274955 no 2575 0.25922568576778 3589 4907387
SGTC_747 3448-8087 38.7 µM -0.645816341479128 0.239171833013591 no 2576 0.259199151807212 3593 5168703
SGTC_1664 st014217 9.02 µM -0.646811200839188 0.238832670005796 no 2577 0.258877071125693 3642 3982782
SGTC_1179 1021-1431 9.29 µM -0.648242511208731 0.238345175918573 no 2578 0.258414055154459 3561 2840958
SGTC_3053 9095903 49.47 µM -0.648436332598037 0.238279203658333 no 2579 0.25835138868519 3641 17174018
SGTC_3233 9132340 49.47 µM -0.648699029910711 0.238189803615609 no 2580 0.258266465774362 3538 17682950
SGTC_2920 7982904 15.77 µM -0.649596721841146 0.237884443626761 no 2581 0.25797637557336 3551 6456808
SGTC_694 1315-0438 43.2 µM -0.649937090713307 0.237768719483394 no 2582 0.257866429182036 3543 6793154
SGTC_1961 st076550 68.7 µM -0.650315053954267 0.237640249587003 no 2583 0.257744367506625 3576 1579337
SGTC_1723 st034307 2.5525 µM -0.650523613436906 0.23756937642346 no 2584 0.257677026921696 3606 867466
SGTC_2000 st075254 36.4 µM -0.651085753116421 0.237378406605136 no 2585 0.257495566339816 3579 17234175
SGTC_1774 st048371 48.465 µM -0.653006693000256 0.236726462431299 no 2586 0.256875981829966 3573 4242727
SGTC_1154 4088-0362 150 µM -0.653054337224559 0.236710305073076 no 2587 0.256860624414467 3604 6618304
SGTC_843 0310-0051 143 µM -0.653198283801043 0.236661492843095 no 2588 0.256814228253795 3585 2065037
SGTC_231 b-estradiol 524 µM -0.653785494992674 0.236462427126883 no 2589 0.256625006397355 3549 450 A steroid.
SGTC_1248 0469-0687 58.6 µM -0.654154145409015 0.236337501036443 no 2590 0.256506250273072 3587 4017482
SGTC_2307 7538926 6.34 µM -0.654488356722092 0.236224276878817 no 2591 0.25639861302267 3595 96582
SGTC_3228 9131799 49.47 µM -0.654499526306244 0.236220493361414 no 2592 0.2563950161143 3575 17015818
SGTC_1233 0325-0408 14.2 µM -0.654916112140065 0.236079405432048 no 2593 0.256260882983206 3618 12874
SGTC_2012 4023501 200 µM -0.655925596142929 0.235737709329221 no 2594 0.255935999116394 3562 3477460
SGTC_283 0987-0079 11.7 µM -0.657513725517233 0.235200702374132 no 2595 0.255425324229261 3626 411556
SGTC_914 3820-6779 408 µM -0.658127939135769 0.234993194675439 no 2596 0.255227962128846 3575 2893481
SGTC_1235 benzylparaben 21.5 µM -0.658280707725808 0.234941598607085 no 2597 0.255178886169252 3592 7180
SGTC_544 k015-0020 52.4 µM -0.658989666931702 0.234702236656208 no 2598 0.25495120203615 3603 3008304
SGTC_3274 9138298 49.47 µM -0.659597417217816 0.234497152694946 no 2599 0.254756106073288 3594 17015756
SGTC_1232 0279-0259 161 µM -0.660715279740062 0.234120191521677 no 2600 0.254397461477672 3638 1560000
SGTC_3287 9117173 37.0625 µM -0.660789788442781 0.234095077926113 no 2601 0.254373566209746 3577 2789709
SGTC_3067 9117431 49.47 µM -0.661013816758569 0.234019576854515 no 2602 0.254301726432527 3602 17150885
SGTC_268 camptothecin 39.6153 µM -0.662292732159235 0.233588820602671 no 2603 0.253891816870411 3632 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_2290 7904846 200 µM -0.662514612287144 0.23351413311352 no 2604 0.253820736627207 3626 2962154
SGTC_400 oxethazaine 37.5 µM -0.662623905316946 0.233477348649624 no 2605 0.253785727980594 3584 4621 A local anesthetic.
SGTC_393 acivicin 6.25 µM -0.662634246250703 0.233473868395544 no 2606 0.253782415713125 3536 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1
SGTC_2286 7945697 125 µM -0.662762057954052 0.233430855584126 no 2607 0.253741478677932 3579 1245733
SGTC_1671 st016596 74.5 µM -0.663197648475224 0.233284298176213 no 2608 0.253601988672938 3647 2829167
SGTC_856 0433-0016 11.3 µM -0.663603610934704 0.23314775531698 no 2609 0.253472022792713 3620 3911780
SGTC_3179 9107801 49.47 µM -0.663949723858998 0.233031377510328 no 2610 0.253361244944936 3621 4818259
SGTC_2462 5162487 171.77 µM -0.666010818343352 0.232339018803506 no 2611 0.252702092779521 3591 2259986
SGTC_2910 7948405 25.97 µM -0.666769138980815 0.232084573526851 no 2612 0.252459804088708 3578 2971328
SGTC_1104 tacrolimus 29.8 µM -0.668932878945405 0.231359410317437 no 2613 0.251769147763012 3668 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41
SGTC_1896 st058441 89 µM -0.670140339140988 0.230955287968224 no 2614 0.251384165902156 3578 688759
SGTC_2807 7945238 51.95 µM -0.671835360685951 0.230388650218446 no 2615 0.250844257346284 3649 17148797
SGTC_2378 9074213 121.43 µM -0.672768090333586 0.230077174906828 no 2616 0.250547420682483 3622 657714
SGTC_957 1187-1561 14.1 µM -0.672896500252606 0.230034312216839 no 2617 0.250506569431003 3612 1538454
SGTC_2553 4-methylesculetin 85.09 µM -0.673094369625494 0.229968273002455 no 2618 0.250443627843219 3636 5319502
SGTC_2225 6654152 15.4 µM -0.673679830036455 0.229772936828805 no 2619 0.250257443936533 3590 97582 YGR029W | YLR033W ERV1 | RSC58
SGTC_2532 xanthone 78.9 µM -0.674362064865774 0.22954542957697 no 2620 0.250040577153814 3550 7020 An insecticide.
SGTC_1070 indatraline 8.81 µM -0.674490759476595 0.229502527485965 no 2621 0.249999679274407 3618 10314472 A monamine transport inhibitor. YGL099W LSG1
SGTC_2743 auranofin 4.32 µM -0.674570334613463 0.229476002284854 no 2622 0.249974392855984 3586 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold.
SGTC_1978 st071761 42 µM -0.674904290395383 0.229364701774406 no 2623 0.249868287254504 3591 5147680
SGTC_1408 3909-7976 48.8 µM -0.675210431264035 0.22926269798554 no 2624 0.249771040112342 3672 24152374
SGTC_235 0330-0087 5 mM -0.675657224877608 0.22911387543948 no 2625 0.24962915001329 3660 46494818 YHR062C RPP1
SGTC_2440 5628896 157.78 µM -0.675727441739371 0.229090491823428 no 2626 0.249606854847365 3652 5522048
SGTC_343 4130-2827 29.8 µM -0.675755163805909 0.229081260190726 no 2627 0.249598052864386 3657 1118244
SGTC_1510 1123-0200 71.5 µM -0.676197792103607 0.228933890289432 no 2628 0.249457537094492 3702 5378812 YNL149C | YNL150W PGA2 | YNL150W
SGTC_2929 9013348 24.6 µM -0.676850780968737 0.228716579519267 no 2629 0.249250317519611 3639 2995952
SGTC_404 fumagillin 50 µM -0.67722727822663 0.2285913361534 no 2630 0.249130881443076 3625 12015870 A methionine aminopeptidase binder.
SGTC_1367 1812-0510 76.9 µM -0.677527600320724 0.228491460393427 no 2631 0.24903563221471 3634 1142582 YDR527W RBA50
SGTC_2283 7944793 200 µM -0.681232715918748 0.227261297970253 no 2632 0.247862124960481 3633 2970533
SGTC_969 1313-0238 134 µM -0.68149151848347 0.227175510724507 no 2633 0.24778026583642 3662 5212874
SGTC_2400 5203494 178.7 µM -0.681703061101013 0.227105402650876 no 2634 0.247713365733026 3620 6777674
SGTC_3286 9117135 37.221 µM -0.682098761292025 0.226974295028443 no 2635 0.247588251914893 3620 3438150
SGTC_2506 ethyl hematommate 54.16 µM -0.685375767103443 0.225890164254537 no 2636 0.246553415823459 3642 3940691 An allergen.
SGTC_2432 5630864 12.22 µM -0.686631431395261 0.22547553048635 no 2637 0.246157508168053 3628 5714970
SGTC_589 1227-0070 34.1 µM -0.686875335332823 0.225395040797667 no 2638 0.246080645460625 3657 2841384
SGTC_1474 0330-0125 5.35 µM -0.688020844427482 0.225017233961758 no 2639 0.245719827545393 3657 X1474
SGTC_565 1418-0001 44.5 µM -0.688853813604935 0.224742733196855 no 2640 0.245457633433842 3688 2862145
SGTC_64 000l-0018 272.079 µM -0.690864370845512 0.224080947229967 no 2641 0.244825389183398 3619 6811119
SGTC_161 4065-0411 162.148 µM -0.691025836846501 0.224027847868379 no 2642 0.24477465228128 3670 1906281 YLR208W SEC13
SGTC_1247 0448-0043 5.84 µM -0.691373861500251 0.223913421541185 no 2643 0.244665312950841 3704 3089013 YGL099W LSG1
SGTC_1610 st001799 48.1 µM -0.692774101156407 0.223453375327053 no 2644 0.24422566385014 3599 621897
SGTC_1375 2910-0797 186 µM -0.692779022916547 0.223451759240568 no 2645 0.244224119260912 3664 742508
SGTC_1306 1185-0270 9.02 µM -0.692923673449216 0.223404265427653 no 2646 0.244178726134867 3663 1548076
SGTC_3044 9093193 49.47 µM -0.695399413641592 0.222592284507156 no 2647 0.243402513956827 3650 25236277
SGTC_109 0132-0036 33.701 µM -0.696295299598209 0.222298871402859 no 2648 0.243121958110159 3546 67274 A color developer.
SGTC_2041 5107442 45.335 µM -0.699785617915915 0.221157858174772 no 2649 0.242030598894692 3675 793005
SGTC_183 3914-0051 30.55 µM -0.70208587008541 0.220407722560415 no 2650 0.2413128068248 3673 1596232
SGTC_440 fluspirilene 35.1 µM -0.702404962797892 0.220303778490749 no 2651 0.241213325608296 3725 3396 An atypical antipsychotic.
SGTC_424 splitomicin 100 mM -0.702569385743486 0.220250228886496 no 2652 0.241162073364634 3703 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_2846 9008642 19.48 µM -0.702842307246615 0.220161359726166 no 2653 0.241077014126635 3680 2992898
SGTC_93 0109-0045 59.227 µM -0.703020450929377 0.220103363374064 no 2654 0.241021502325263 3755 88733
SGTC_1791 st048313 56.1 µM -0.703210863682827 0.220041382401134 no 2655 0.240962175014364 3618 1204976
SGTC_1879 gemcitabine 100 µM -0.703629333798902 0.219905202003891 no 2656 0.240831819293799 3688 60750 A nucleoside analog which inhibits DNA replication.
SGTC_1471 k673-0312 37 µM -0.70363933540333 0.219901947829426 no 2657 0.240828704209073 3671 24099884
SGTC_1617 st002906 78 µM -0.70399959170567 0.219784751376449 no 2658 0.240716513938476 3701 5150859
SGTC_1409 3909-8004 61.9 µM -0.704057433876871 0.219765937843979 no 2659 0.24069850349994 3700 2119279
SGTC_18 0111-0177 500 nM -0.705616989082331 0.219259031254544 no 2660 0.24021317809531 3771 721752
SGTC_2683 piperine 63.03 µM -0.706370916734442 0.219014221211136 no 2661 0.239978751119536 3659 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_1311 1190-0148 100 µM -0.709029347864165 0.218152249788135 no 2662 0.239153132449726 3737 1961333
SGTC_1629 st005085 44.9 µM -0.709160499747907 0.218109775684965 no 2663 0.23911244133609 3684 24207091
SGTC_3039 9090270 49.47 µM -0.709530261211973 0.217990052506294 no 2664 0.238997739717496 3666 17173750
SGTC_2999 9069765 71.4286 µM -0.710062019272902 0.217817943718604 no 2665 0.238832838799949 3715 2097066
SGTC_2390 9097792 176.6 µM -0.711706581560961 0.217286161060684 no 2666 0.238323245626499 3700 4497149
SGTC_1320 1313-0481 95.3 µM -0.712757905114895 0.216946600236663 no 2667 0.237997788988303 3711 6813365 YLR208W SEC13
SGTC_1888 azatryptophan 97.5 µM -0.713402203185021 0.216738653854879 no 2668 0.237798455082476 3669 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides
SGTC_2384 9036245 200 µM -0.71519817184212 0.216159616086039 no 2669 0.237243299269061 3704 6462766
SGTC_1997 st073024 93.8 µM -0.715538833780305 0.216049884527484 no 2670 0.23713807688868 3693 686268
SGTC_465 cgp-37157 41 µM -0.715657878405692 0.216011546343398 no 2671 0.237101312878259 3616 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange.
SGTC_1041 0206-0046 107 µM -0.715720211722414 0.215991473542916 no 2672 0.237082064012762 3732 50494
SGTC_1088 bifonazole 369 nM -0.715859575853409 0.215946598909567 no 2673 0.237039030721323 3643 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase.
SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM -0.716128911896627 0.215859889204955 no 2674 0.23695587646291 3756 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_2598 perillyl alcohol 100 µM -0.717615073352907 0.215381799234123 no 2675 0.236497330484776 3707 10819 An apoptosis inducer.
SGTC_1300 1094-0077 113 µM -0.7193060473726 0.21483857007632 no 2676 0.235976185332762 3666 5532636
SGTC_2033 5192550 145 µM -0.719316342457999 0.214835265196837 no 2677 0.235973014406299 3706 182073
SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM -0.720586316311295 0.214427810798053 no 2678 0.23558203766722 3768 5393153
SGTC_2499 avocadenofuran 51.48 µM -0.723772664887541 0.213407493123439 no 2679 0.234602656853451 3710 6857792 A insecticide and lysyl oxidase inhibitor.
SGTC_2424 5537928 59.2 µM -0.72382599501459 0.21339044011358 no 2680 0.234586284074452 3787 5382802
SGTC_1276 0871-0068 94.2 µM -0.72431379987993 0.213234494955822 no 2681 0.234436553379477 3701 3414906
SGTC_3184 9108758 49.47 µM -0.72474902272265 0.213095415732849 no 2682 0.23430300727607 3719 902885
SGTC_2173 5763948 167 µM -0.725374874673562 0.212895512116415 no 2683 0.23411104135011 3726 2867177
SGTC_578 3460-0051 92 µM -0.725680014319542 0.212798087044682 no 2684 0.234017478261234 3782 2876744
SGTC_3116 9124943 49.47 µM -0.726165551461801 0.212643118274884 no 2685 0.233868643708198 3640 41905195 YPL160W CDC60
SGTC_1522 st012842 45.6 µM -0.726746341120309 0.2124578343754 no 2686 0.23369067975904 3632 3491067 YOR116C RPO31
SGTC_1509 1326-1131 80 µM -0.728478821053743 0.211905698104674 no 2687 0.233160264332897 3669 768313
SGTC_869 0564-0080 44.1 µM -0.728805974583209 0.211801529533485 no 2688 0.233060178198167 3746 6843321
SGTC_2983 9022671 12.99 µM -0.729250854628222 0.211659923887134 no 2689 0.232924114256803 3717 6405161
SGTC_1013 4112-3890 241 µM -0.7315434554969 0.210931066446075 no 2690 0.232223635832309 3694 705171
SGTC_1256 0570-0116 285 µM -0.733368631652914 0.210351864941555 no 2691 0.231666812919096 3744 410638
SGTC_54 0159-0055 9 µM -0.733416372756593 0.210336727319605 no 2692 0.231652258103251 3751 3319099
SGTC_722 3534-0461 190 µM -0.733522740362738 0.210303002862584 no 2693 0.231619831675929 3713 658262
SGTC_833 3852-0053 558 µM -0.733992655054447 0.210154051728231 no 2694 0.231476607301247 3770 3123681
SGTC_2914 7968218 45.32 µM -0.735369631240446 0.209717941914996 no 2695 0.231057205906581 3701 2977111
SGTC_700 3453-2283 142 µM -0.73697435601116 0.209210372615518 no 2696 0.230568972123911 3788 565664
SGTC_2315 7733312 200 µM -0.737366196637325 0.209086544621329 no 2697 0.230449843158774 3700 726316
SGTC_2570 licareol 100 µM -0.741923805768425 0.207649439399395 no 2698 0.229066750728581 3758 443158
SGTC_1955 wogonin 32.4 µM -0.742329119234827 0.20752191916209 no 2699 0.228943976591997 3773 5281703 A flavanone.
SGTC_87 0100-0052 35.5 µM -0.743604887443396 0.207120837575162 no 2700 0.228557772778225 3812 200187 YGR083C | YDR527W GCD2 | RBA50
SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM -0.744614591708717 0.206803727658802 no 2701 0.228252372117604 3786 279621
SGTC_2986 9022445 71.43 µM -0.744906367969288 0.206712145327404 no 2702 0.22816416261851 3666 6459286
SGTC_2931 9014674 55.67 µM -0.745014230910295 0.206678295536409 no 2703 0.228131558458134 3761 2996810
SGTC_904 1141-0088 396 µM -0.745399087309184 0.206557545786691 no 2704 0.228015247735135 3734 1378119
SGTC_2638 epoxomicin 18 µM -0.745804495525445 0.206430393052133 no 2705 0.227892761954238 3762 9915668 A protesome inhibitor.
SGTC_892 0929-0076 29 µM -0.746037088407203 0.206357463273887 no 2706 0.227822505499349 3749 5751038
SGTC_911 3456-4043 236 µM -0.747302345733059 0.205961007830125 no 2707 0.227440538428009 3836 914281
SGTC_2101 5377231 179.231 µM -0.747930075222329 0.205764483000287 no 2708 0.22725116785776 3775 2844213
SGTC_880 0833-0487 87.2 µM -0.754119557290422 0.203832691388274 no 2709 0.225388717449618 3740 76075
SGTC_3247 9135149 49.47 µM -0.754895793828684 0.203591186353758 no 2710 0.225155754871711 3741 8934436 YOR116C RPO31
SGTC_2926 9010726 65.15 µM -0.755123984833071 0.203520223354477 no 2711 0.225087296591195 3779 2994293
SGTC_1907 st060210 83.7 µM -0.755820360788081 0.203303755098615 no 2712 0.224878453745235 3761 688793
SGTC_530 4358-1714 28 µM -0.755904827300019 0.203277508055555 no 2713 0.224853129747239 3838 1564641
SGTC_3090 9117696 49.47 µM -0.757291843260183 0.202846797363332 no 2714 0.224437518284817 3717 7923821
SGTC_1461 k072-0203 53.8 µM -0.758583538424221 0.202446177352258 no 2715 0.224050861522282 3700 5418714
SGTC_1004 4084-0029 199 µM -0.765287290829293 0.200374615095694 no 2716 0.22205024514162 3813 716894 YLR208W SEC13
SGTC_2716 st080858 38.6235 µM -0.766493153557705 0.200003340933486 no 2717 0.221691462025534 3768 5296050
SGTC_1292 0kpi-0043 232 µM -0.766575227177908 0.199978086255183 no 2718 0.221667054517629 3806 3333905
SGTC_2361 9034121 116 µM -0.766997161959031 0.199848283977341 no 2719 0.221541601455128 3785 6496917
SGTC_925 2064-1272 59.6 µM -0.767311375639961 0.199751653502164 no 2720 0.221448203271667 3781 6815817
SGTC_478 N-arachidonylglycine 10 µM -0.768841098221727 0.199281617901116 no 2721 0.220993823862166 3727 5283389
SGTC_2382 9035899 200 µM -0.768884258160525 0.19926836587909 no 2722 0.22098101164374 3796 6462679
SGTC_20 0481-0013 4.944 µM -0.769065492460236 0.199212724676782 no 2723 0.220927216082738 3786 182045
SGTC_1769 st044406 64.4 µM -0.770763207572666 0.198691959388981 no 2724 0.220423649502024 3786 670903
SGTC_2357 9067248 200 µM -0.77086642100744 0.198660325697127 no 2725 0.220393056149299 3796 9150235
SGTC_2643 anethole 100 µM -0.771174741662181 0.198565847167612 no 2726 0.2203016817426 3793 637563 An anti-fungal, anti-helmenthic and channel blocker.
SGTC_233 rapamycin 362 pM -0.771789191384331 0.198377642518714 no 2727 0.220119647219832 3792 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C
SGTC_1273 0849-0096 14.1 µM -0.773611085348187 0.197820233352462 no 2728 0.21958040732941 3807 5286025
SGTC_2257 7960413 200 µM -0.773852562669782 0.197746424361234 no 2729 0.219508992427319 3775 2974689 YIL048W NEO1
SGTC_1764 st044502 93.5 µM -0.77498255961135 0.197401255218655 no 2730 0.219174982614874 3828 8407
SGTC_425 3825-7017 13.1 µM -0.776440579420114 0.196956426887871 no 2731 0.218744446284805 3899 3397440
SGTC_2852 9023854 51.95 µM -0.776632096295682 0.196898041984657 no 2732 0.218687929761007 3871 19798528
SGTC_2533 agelasine 13.65 µM -0.776731832098282 0.196867641162648 no 2733 0.218658501109358 3824 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase.
SGTC_2869 9037858 32.47 µM -0.776901097113882 0.196816053400695 no 2734 0.218608561963427 3742 27187042
SGTC_1864 st057645 30.4 µM -0.777528814938986 0.196624812116938 no 2735 0.21842342041507 3819 688666
SGTC_1596 piperlongumine 63 µM -0.784588228979862 0.194481842853157 no 2736 0.216347516873275 3804 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_2915 7971052 15.16 µM -0.785084214945161 0.194331816797386 no 2737 0.216202097013091 3651 5741558
SGTC_1765 st044815 90.4 µM -0.786002731809526 0.194054169554309 no 2738 0.215932943352814 3858 645695
SGTC_1899 st063254 59.6 µM -0.789281580472444 0.193065019249321 no 2739 0.214973724904996 3753 3093813
SGTC_211 3455-0679 143.504 µM -0.790784953945395 0.19261251859951 no 2740 0.214534745721636 3849 748649
SGTC_1844 rapamycin 4 nM -0.792547603104256 0.192082804806225 no 2741 0.214020723328744 3760 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2
SGTC_2353 9059630 146.67 µM -0.79275803494807 0.192019625149559 no 2742 0.213959405291892 3863 4779114
SGTC_1650 st011916 45.8 µM -0.79337267068873 0.191835160916182 no 2743 0.213780364273117 3770 242528
SGTC_1167 k781-0610 148 µM -0.793764734121591 0.191717551687996 no 2744 0.213666203303465 3834 4525169
SGTC_1667 st014849 34.6 µM -0.794758826911556 0.191419546673763 no 2745 0.213376902752642 3879 5348460
SGTC_2351 9026858 72.31 µM -0.799252983533741 0.190075852699109 no 2746 0.212071867599241 3772 1409300
SGTC_547 1120-0019 610 nM -0.799855065636398 0.189896279382223 no 2747 0.211897387278285 3751 3676939
SGTC_1846 st056244 14.8 µM -0.800409753681278 0.189730933870206 no 2748 0.211736715859875 3865 5393182
SGTC_3050 9093513 49.47 µM -0.800871638958167 0.189593319278318 no 2749 0.211602980189437 3831 25236664
SGTC_1612 st002233 45.4 µM -0.80133732465158 0.189454634570397 no 2750 0.211468194208096 3839 1035021
SGTC_2775 cyproheptadine 69.59 µM -0.801437574712655 0.189424787515267 no 2751 0.211439184857284 3825 2913 A selective serotonin reuptake inhibitor.
SGTC_2035 5154463 94.595 µM -0.802178303405054 0.189204342981578 no 2752 0.211224912501975 3841 2769623
SGTC_2456 5770359 74.46 µM -0.803605037254754 0.188780185280017 no 2753 0.210812556520406 3822 3118787
SGTC_1340 1486-1359 257 µM -0.804949385021796 0.188381057063972 no 2754 0.210424444206379 3775 4309068
SGTC_2071 5230951 39.92 µM -0.807458493537537 0.187637512490227 no 2755 0.209701189265632 3874 1799272
SGTC_2651 TUB2.036 5 µM -0.807529800627483 0.187616408010062 no 2756 0.209680656255763 3890 15992207 YFL037W TUB2
SGTC_2626 ethyl orsellinate 100 µM -0.808098110395504 0.187448260020696 no 2757 0.20951705265965 3857 75653 A natural product.
SGTC_2418 pentamidine 31.67 µM -0.80946240912005 0.187044980075377 no 2758 0.209124608402799 3808 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_2707 st078556 66.6 µM -0.81147115211493 0.186452183332848 no 2759 0.208547576452792 3830 17250899
SGTC_2241 6772625 37.8075 µM -0.812218071213094 0.18623205842103 no 2760 0.208333255965463 3770 2285411
SGTC_1361 1608-0041 5.61 µM -0.812512143191634 0.186145436518938 no 2761 0.208248910799826 3800 X1361
SGTC_1999 st074831 12.5 µM -0.815054650101527 0.185397556830445 no 2762 0.207520514321404 3837 17112523
SGTC_2194 5927483 104.545 µM -0.817855763297508 0.184575770884375 no 2763 0.206719776169068 3864 760979
SGTC_1438 4092-1045 4 µM -0.823548788851455 0.182912554330786 no 2764 0.205097992211734 3836 1351342
SGTC_1815 st051655 58.2 µM -0.82625634000965 0.182124836057862 no 2765 0.204329347290094 3810 5984156
SGTC_1447 4239-0816 81.9 µM -0.827103033112923 0.181878940284172 no 2766 0.204089332607139 3869 1341554
SGTC_2150 5556613 200 µM -0.827306128122882 0.181819988523727 no 2767 0.204031785627233 3875 743190
SGTC_1005 4092-0690 4.4 µM -0.827349623888093 0.181807364696634 no 2768 0.204019462357276 3906 1529343
SGTC_3339 9145883 14.936 µM -0.827785161965882 0.181680988201316 no 2769 0.203896089664521 3784 2030670
SGTC_1638 st008370 60.6 µM -0.82799706387588 0.181619522251546 no 2770 0.203836081351817 3851 24207134
SGTC_3159 9100096 49.47 µM -0.828620359015937 0.181438799762189 no 2771 0.203659631987472 3828 25236875
SGTC_2765 myclobutanil 7.74 µM -0.830021229971306 0.181033032601645 no 2772 0.203263390285203 3904 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11
SGTC_2443 5493264 126.67 µM -0.830124843799667 0.181003043093659 no 2773 0.203234101003331 3899 5340055
SGTC_836 0330-0104 1.35 µM -0.830728785252827 0.180828303026948 no 2774 0.203063430575139 3867 46494820
SGTC_1761 st044296 37 µM -0.832057230324875 0.180444312562258 no 2775 0.202688320807856 3879 1826700
SGTC_1063 disulfiram 1.84 µM -0.832061958953765 0.180442946654204 no 2776 0.202686986336577 3861 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_748 act1.228 77.9 µM -0.836097871054667 0.179279502186026 no 2777 0.201549922984952 3831 4421505 YNR035C ARC35
SGTC_803 4488-1585 147 µM -0.837423065521031 0.178898515501737 no 2778 0.201177402548628 3906 747204
SGTC_147 4466-0538 29.23 µM -0.837630323989032 0.1788389758561 no 2779 0.201119178257785 3925 6742687 YHR072W ERG7
SGTC_1220 1838-0075 193 µM -0.837713866570138 0.178814979902521 no 2780 0.201095711833344 3809 5529645
SGTC_2004 4023728 41.89 µM -0.838240087180337 0.178663880035103 no 2781 0.200947938540786 3899 360084 YDR527W RBA50
SGTC_556 4058-0063 51.5 µM -0.838517133959698 0.178584360674849 no 2782 0.200870164439376 3941 6615692
SGTC_173 1273-0061 2.693 µM -0.840664042583635 0.17796889998484 no 2783 0.200268084955711 3893 2847414 YPL266W DIM1
SGTC_2729 fluphenazine 10.66 µM -0.840943680132765 0.177888834023695 no 2784 0.200189743242538 3813 3372 An atypical antipsychotic.
SGTC_1195 1502-0147 41.1 µM -0.842039756693388 0.17757522392575 no 2785 0.199882850100409 3881 817940
SGTC_974 1326-0144 138 µM -0.842172162293668 0.177537363589135 no 2786 0.199845796697872 3933 5411856
SGTC_2902 5787006 60.46 µM -0.843592945757078 0.177131422468137 no 2787 0.19944845378202 3852 591003
SGTC_1155 4088-0394 48.2 µM -0.843798485588458 0.177072744953529 no 2788 0.1993910109586 3874 2326248
SGTC_47 0149-0135 24.25 µM -0.844138596393809 0.176975677090618 no 2789 0.199295981068103 3919 5239155
SGTC_670 4204-0025 119 µM -0.844289989357648 0.176932480248818 no 2790 0.199253689342854 3903 719039
SGTC_2879 9041815 71.43 µM -0.844653837427524 0.176828691002015 no 2791 0.199152070249011 3900 4942971
SGTC_2313 7726885 200 µM -0.847430201502611 0.176037988673964 no 2792 0.198377688250353 3940 726423
SGTC_2289 7946404 165.07 µM -0.849064401569409 0.17557362036816 no 2793 0.197922728751659 3935 1246120 YPR165W RHO1
SGTC_2252 omeprazole 400 µM -0.851055750939591 0.17500881616653 no 2794 0.197369192017086 3849 4594 A proton pump inhibitor.
SGTC_288 1315-0019 35.1 µM -0.851366719414107 0.174920720703283 no 2795 0.197282836497714 3969 6811474
SGTC_2129 girgensonine 121.053 µM -0.851472532320835 0.174890750973155 no 2796 0.197253457610901 3932 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_1666 st014829 29 µM -0.852255548307311 0.174669076124355 no 2797 0.197036135985504 3905 3858230
SGTC_2860 9025725 38.96 µM -0.852670965066492 0.17455154249621 no 2798 0.196920898289367 3901 40546248
SGTC_639 0833-0042 114 µM -0.853466504044359 0.174326601331856 no 2799 0.196700327613016 3891 5978911 YPR085C | YHR062C ASA1 | RPP1
SGTC_1778 st046819 58.9 µM -0.853960744552171 0.17418694606051 no 2800 0.196563370169745 3954 671715
SGTC_273 hydroxyurea 18.1 mM -0.854878733108645 0.173927742989718 no 2801 0.196309142593056 3971 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12
SGTC_832 4083-0019 164 µM -0.855806874933969 0.173665922531363 no 2802 0.196052305924721 3973 1990758
SGTC_3298 9116858 71.43 µM -0.856340384705201 0.173515537779815 no 2803 0.195904764671475 3970 2506942
SGTC_2403 6032726 181.2 µM -0.856826634138068 0.173378546898279 no 2804 0.195770351888034 3980 2881040
SGTC_959 1222-0044 107 µM -0.857920925146916 0.173070504583031 no 2805 0.195468064401536 3877 6083612
SGTC_1850 st056238 17 µM -0.860213758954111 0.172426204428109 no 2806 0.194835610799011 3924 5393177
SGTC_1242 0402-0103 60.1 µM -0.861874873357535 0.171960378209548 no 2807 0.194378188622918 3857 432868
SGTC_2105 5350118 200 µM -0.862173113496656 0.171876827901455 no 2808 0.194296131323125 3915 2133313
SGTC_3314 9135860 59.4275 µM -0.863218791960136 0.171584091741575 no 2809 0.194008591748167 3869 25252478
SGTC_2764 methyldopa 94.69 µM -0.865710097650363 0.170887938810184 no 2810 0.193324580584331 3901 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent.
SGTC_1533 dihydroergotamine mesylate 29.4 µM -0.865761731812819 0.17087352966545 no 2811 0.19331041952855 4003 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release.
SGTC_3221 9128209 49.47 µM -0.869615231060329 0.169800357946496 no 2812 0.192255355670082 3971 16460723
SGTC_784 4579-0127 173 µM -0.872104893085607 0.169109308428522 no 2813 0.191575578517297 4018 1948547
SGTC_576 1073-0113 22.7 µM -0.8721320379051 0.169101783872723 no 2814 0.191568175020894 4073 5439563
SGTC_822 1487-0950 154 µM -0.87275083984127 0.168930310024464 no 2815 0.191399450103936 3939 1958375
SGTC_939 1165-0479 45.3 µM -0.873053212798607 0.168846561245668 no 2816 0.191317037061563 3891 1377347
SGTC_1344 1488-0097 29.1 µM -0.873448007864319 0.168737254310427 no 2817 0.19120946672144 3968 747966
SGTC_338 4055-0136 114 µM -0.874416148510101 0.168469397688336 no 2818 0.190945833139758 3879 2900563
SGTC_116 0155-0182 31.788 µM -0.876007623677759 0.16802967682294 no 2819 0.190512944651123 3864 771486
SGTC_2057 5236571 38.335 µM -0.878333196656816 0.167388455977045 no 2820 0.189881462813386 3937 54684039 YBR257W POP4
SGTC_141 0443-0274 32.331 µM -0.878511800797185 0.167339275463827 no 2821 0.189833018242604 3987 1627241
SGTC_1173 0443-0020 122 µM -0.881252450487838 0.166585776981941 no 2822 0.18909059803287 3940 5331295
SGTC_1942 st076330 65.2 µM -0.881795027286584 0.166436864120062 no 2823 0.188943830628147 3944 24208414
SGTC_401 neomycin 50 µM -0.883829575647783 0.165879237971513 no 2824 0.188394109127982 3928 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis.
SGTC_1445 4239-0156 97.7 µM -0.885329589605323 0.165468890509763 no 2825 0.187989447747633 4054 4008346
SGTC_2951 9072950 58.06 µM -0.886405663901854 0.165174921863643 no 2826 0.187699484112941 3933 16488155
SGTC_2680 butyl paraben 22.24 µM -0.886426836000005 0.165169141331647 no 2827 0.187693781760649 4003 7184 An antifungal and steroid mimetic.
SGTC_1255 0566-0045 221 µM -0.886537830853958 0.165138838999985 no 2828 0.187663888895073 4004 2788469
SGTC_824 1304-0008 100 µM -0.886555047459755 0.165134139074763 no 2829 0.187659252423947 3967 768245
SGTC_3196 9111891 49.47 µM -0.888904303564647 0.164493632608757 no 2830 0.187027256189749 3946 18891510
SGTC_2415 st077333 57.7 µM -0.889175446571276 0.16441981135523 no 2831 0.186954398222057 3927 2766255
SGTC_752 1896-0090 130 µM -0.891836785095019 0.163696376824963 no 2832 0.18624021087828 3927 772567
SGTC_789 1309-1135 70.6 µM -0.892948283303786 0.16339484971894 no 2833 0.185942434331974 3943 3092424
SGTC_1014 4130-3005 69.3 µM -0.893466490989191 0.163254393787881 no 2834 0.18580370457514 3976 743608
SGTC_2734 clemastine 41.6 µM -0.89534597245902 0.162745634238679 no 2835 0.185301086098004 3981 26987 Clemastine is a selective histamine H1 antagonist.
SGTC_2524 avocatin b 10.57 µM -0.895422829205402 0.162724851745115 no 2836 0.185280550741529 3920 6710748
SGTC_2084 5306078 60.6385 µM -0.895984080868669 0.162573138492248 no 2837 0.185130632734165 3904 679340
SGTC_3318 9139014 38.6185 µM -0.896307765570033 0.162485684377624 no 2838 0.185044206384169 3956 16643984
SGTC_1987 st072290 61.9 µM -0.900239037049237 0.161425965926453 no 2839 0.183996527955589 3993 54697379
SGTC_2676 harmalol 100 µM -0.900631516368628 0.16132041670552 no 2840 0.183892135911323 3906 5459187 A monoamine oxidase inhibitor
SGTC_1432 4049-0298 68.4 µM -0.904058265511036 0.160400775893567 no 2841 0.182982253344583 3995 741646
SGTC_513 4245-1575 41.7 µM -0.905186052315533 0.160098861105204 no 2842 0.182683414859712 3893 719745
SGTC_731 3966-0296 387 µM -0.907378018504616 0.159513123146883 no 2843 0.182103464745167 3978 660956
SGTC_2827 7993847 71.43 µM -0.907593070799583 0.159455732456064 no 2844 0.182046628303961 4060 2985692
SGTC_922 1866-0035 480 µM -0.90818694288192 0.159297316899072 no 2845 0.181889730717255 3930 3156169
SGTC_2519 cryptotanshinone 88.04 µM -0.909538581434061 0.158937151258191 no 2846 0.181532950993481 3969 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE)
SGTC_2849 9019321 12.99 µM -0.911502224263438 0.158414858840674 no 2847 0.18101540709427 4005 16489627
SGTC_2777 climbazole 1.536 µM -0.914060782584884 0.157736021124033 no 2848 0.180342454015335 3885 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2
SGTC_2161 5662504 8.5105 µM -0.914551222597578 0.157606115945715 no 2849 0.180213637799484 3963 2859334
SGTC_2248 tofa 1.1 µM -0.91604617898671 0.157210573550181 no 2850 0.179821337384867 3921 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_538 2922-0838 53.3 µM -0.916200288333226 0.157169835738844 no 2851 0.179780927154905 3952 777039
SGTC_2885 9057732 51.95 µM -0.917485892166318 0.156830265181518 no 2852 0.179444041144281 4060 6471414
SGTC_1324 1418-0026 34.4 µM -0.918563564944497 0.156545988334521 no 2853 0.179161948394113 4026 1372513
SGTC_557 1315-0110 16.2 µM -0.919311142551535 0.156348985966809 no 2854 0.178966425660894 3967 6833801
SGTC_673 1082-0474 110 µM -0.921584851398111 0.155750819994779 no 2855 0.178372581572994 4000 3098046
SGTC_1053 3366-3204 134 µM -0.922219629423523 0.155584092784974 no 2856 0.178207013079804 4031 3632071 YPR165W RHO1
SGTC_119 0121-0043 24.815 µM -0.923163153949522 0.155336489587894 no 2857 0.177961093611355 4012 1092378
SGTC_1601 4'-hydroxyflavanone 55.5 µM -0.923344755491304 0.15528886289852 no 2858 0.177913785702382 4056 165506
SGTC_2110 5483698 200 µM -0.924304121454876 0.155037420230416 no 2859 0.177663998771932 3982 2848765 YHR062C RPP1
SGTC_1430 4049-0248 69.1 µM -0.926227197402576 0.154534206367626 no 2860 0.177163960612908 4006 22774488
SGTC_1915 st067105 30.6 µM -0.92809339258239 0.154046909858647 no 2861 0.176679563372842 3963 69751 YOR207C | YOR116C RET1 | RPO31
SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM -0.933173898351808 0.152725456433173 no 2862 0.175365094547045 3955 279621
SGTC_2148 5546263 113.568 µM -0.934749585950937 0.152317147902921 no 2863 0.174958683039144 4000 792097
SGTC_745 0469-0705 296 µM -0.937533096894004 0.151597627882446 no 2864 0.17424220366468 4103 3486736
SGTC_577 r071-0003 38.6 µM -0.942750858212362 0.150254965953267 no 2865 0.172904176438697 4051 4568517 YMR134W ERG29
SGTC_2685 mycophenolic acid 18.85 µM -0.943882128996898 0.149964909990698 no 2866 0.172614942648041 3990 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_165 k038-0023 64.381 µM -0.944313966415 0.149854286121503 no 2867 0.172504615494545 4029 46368543
SGTC_2199 6590217 200 µM -0.944647153377789 0.149768970763032 no 2868 0.172419522604442 3926 703109
SGTC_1781 st038725 66.3 µM -0.94510412737988 0.149652011382872 no 2869 0.172302859191187 4007 4270275 YIL048W NEO1
SGTC_1541 2',3',6-trimethoxyflavone 64 µM -0.945617906106739 0.149520586015893 no 2870 0.172171753943261 4119 688801
SGTC_2802 7925815 54.55 µM -0.945743229341475 0.149488539834742 no 2871 0.172139783818158 3992 1262923
SGTC_2198 6589944 200 µM -0.945837886712004 0.149464338206141 no 2872 0.172115639107809 4020 5290268
SGTC_685 1278-0033 54.9 µM -0.947901136592323 0.148937464255378 no 2873 0.171589893141198 4072 3590572
SGTC_1252 0493-0875 34.8 µM -0.949078399278179 0.148637393741478 no 2874 0.171290369812711 4016 3960963
SGTC_672 1441-0018 53.7 µM -0.950301525368931 0.148326061553508 no 2875 0.170979532029615 4017 251141
SGTC_3204 9114183 49.47 µM -0.950410910747792 0.148298240072298 no 2876 0.170951751088095 4023 17027248
SGTC_1033 k072-0102 21.3 µM -0.951579439444875 0.148001250010531 no 2877 0.170655156476465 4017 5965931
SGTC_2968 9090663 33.37 µM -0.952189392103886 0.147846384350355 no 2878 0.170500469921903 4008 25236811
SGTC_1025 k007-0731 70 µM -0.952722313162003 0.147711165685939 no 2879 0.170365392420972 3992 6256118
SGTC_1399 3562-5772 25 µM -0.953017677151941 0.147636258328656 no 2880 0.170290557149875 3979 23847490
SGTC_2820 7989630 71.43 µM -0.953897436246875 0.147413293119459 no 2881 0.170067780673231 4012 2984098
SGTC_1862 st057513 3.81 µM -0.954169774341745 0.147344317801068 no 2882 0.169998855897936 4012 5393163
SGTC_797 k781-0471 270 µM -0.954789035047615 0.147187557593619 no 2883 0.169842196759077 4004 23738129
SGTC_755 1995-0008 37.3 µM -0.956424346315747 0.146774131061359 no 2884 0.169428944655605 4001 689533
SGTC_795 0685-0265 78 µM -0.958401966266654 0.146275206454427 no 2885 0.168930052060184 4065 302754
SGTC_90 0870-0863 4.608 µM -0.961449403834208 0.145508614605559 no 2886 0.168163126954595 4056 1738164
SGTC_2540 epiandrosterone 100 µM -0.963474625736779 0.145000661125702 no 2887 0.167654695989554 4076 441302 A steroid.
SGTC_175 3793-3120 23.7 µM -0.966149338315662 0.144331637731506 no 2888 0.166984729582591 4063 5322297
SGTC_1254 0550-0035 264 µM -0.966267613793697 0.144302101707782 no 2889 0.166955143664133 4121 15121435
SGTC_2376 9072922 81.32 µM -0.967012448536726 0.144116193484148 no 2890 0.166768905303383 4094 17087968
SGTC_2249 haloperidol 116.36 µM -0.968557532076095 0.143731061052874 no 2891 0.166383000457655 4037 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_2238 6671620 73.2395 µM -0.969252990116681 0.143557935827939 no 2892 0.166209489033453 3979 729941
SGTC_3223 9129970 49.47 µM -0.969754036873038 0.143433294030968 no 2893 0.166084554188927 4081 17248386
SGTC_1261 0712-0010 12.7 µM -0.969955327843091 0.143383240902972 no 2894 0.166034379841546 4080 2840123
SGTC_1863 st057641 20.1 µM -0.970185737686677 0.143325961537197 no 2895 0.165976959265936 4064 3921635
SGTC_1945 st075991 56.6 µM -0.97168760260534 0.142952979962548 no 2896 0.165602993092988 4078 1084980
SGTC_3095 9117207 49.47 µM -0.972727135976237 0.142695200852912 no 2897 0.165344467397962 4034 17015229
SGTC_2665 lovastatin 100 µM -0.9728482332131 0.142665192120244 no 2898 0.165314368235072 4079 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1
SGTC_2452 5863136 48.41 µM -0.972858736482189 0.142662589538643 no 2899 0.165311757776077 4019 2184096
SGTC_2363 9053361 176 µM -0.974742532346009 0.142196327111742 no 2900 0.164843994794464 4136 6469797 YMR079W SEC14
SGTC_1839 st053978 48 µM -0.974747944554566 0.142194989011559 no 2901 0.164842652131978 4068 3788398
SGTC_1397 3532-0190 20.1 µM -0.978940124596422 0.141161084477798 no 2902 0.163804782486626 4008 5322280
SGTC_2010 4012422 159 µM -0.982983404132677 0.140168743059674 no 2903 0.162807803336049 4052 952393
SGTC_1646 st011709 75.6 µM -0.987760014359324 0.139002539954359 no 2904 0.161635097365424 3993 5757843
SGTC_2884 9058502 51.95 µM -0.989218091898627 0.138647871939231 no 2905 0.161278224266351 4125 6471554
SGTC_2428 5615643 7.78 µM -0.989491240455659 0.13858149892575 no 2906 0.16121142674655 4124 2253075
SGTC_3162 9099653 49.47 µM -0.989671266646176 0.138537765773779 no 2907 0.161167411843544 4063 25237511
SGTC_967 1306-0166 352 µM -0.991269832168098 0.13814984416226 no 2908 0.160776919849429 4069 4437607
SGTC_583 1488-1091 88.9 µM -0.991855345226519 0.13800794404652 no 2909 0.160634047471647 4194 4303273
SGTC_2661 dactinomycin 12.96 µM -0.992329088929861 0.137893204210468 no 2910 0.160518508897643 4049 45006140 An Actinomycin D Classic transcription inhibitor.
SGTC_3248 9135562 49.47 µM -0.992960977957285 0.137740263189308 no 2911 0.160364485707788 4066 17650701
SGTC_2431 5490079 200 µM -0.99332863602954 0.137651329331795 no 2912 0.160274913372205 4131 5722345
SGTC_305 1682-2595 20.8 µM -0.994932418353621 0.137263844257149 no 2913 0.15988456727121 4099 226033
SGTC_2211 7117706 200 µM -0.998053430131309 0.136511923096988 no 2914 0.159126725282402 4015 822771
SGTC_2174 5790901 200 µM -0.999357280028599 0.13619863249311 no 2915 0.158810823326314 4103 786020
SGTC_2840 9008771 71.43 µM -1.0000542223626 0.136031372310447 no 2916 0.158642134062799 4031 2992978
SGTC_2451 5856223 45.7 µM -1.00085261015483 0.13583993895528 no 2917 0.158449035184142 4062 2179896
SGTC_730 1436-0052 41.2 µM -1.0034996416357 0.13520656743537 no 2918 0.157809924873492 4116 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2
SGTC_1128 3448-9350 235 µM -1.0042581624324 0.135025445315219 no 2919 0.157627096976158 4153 619386
SGTC_728 3030-5151 22.5 µM -1.00448673115119 0.134970899557346 no 2920 0.157572031862775 4147 3125388
SGTC_2089 5281248 129.67 µM -1.00487436052303 0.134878430035909 no 2921 0.157478675911228 4078 2737878
SGTC_3057 9095946 49.47 µM -1.00737517622466 0.134282901722277 no 2922 0.156877257921301 4124 24540043
SGTC_2585 alliin 100 µM -1.00794558338526 0.134147321899724 no 2923 0.15674029336638 4161 87310 A garlic compound which reacts with lipids.
SGTC_1511 0906-3109 28.5 µM -1.00929142655788 0.133827801815866 no 2924 0.156417445305248 4111 2882180
SGTC_2327 6189656 200 µM -1.00950801256503 0.133776430481881 no 2925 0.156365530433251 4176 5349088
SGTC_738 1315-0003 72.4 µM -1.0122152040228 0.13313546405374 no 2926 0.155717584088292 4159 6251474
SGTC_629 3448-6466 76.7 µM -1.01240099974615 0.133091551887286 no 2927 0.155673180271529 4108 573744
SGTC_1223 0764-0573 147 µM -1.01342946192107 0.132848658790545 no 2928 0.155427536410642 4094 1609797
SGTC_2262 9014885 67.46 µM -1.01512889461225 0.132447971064752 no 2929 0.1550221948352 4061 6457424
SGTC_295 k015-0027 31 µM -1.01740939657387 0.13191159012723 no 2930 0.154479356884487 4138 3887424
SGTC_14 0354-0009 295 µM -1.01789855937609 0.131796732999193 no 2931 0.154363083169838 4187 1713507
SGTC_2047 4141938 200 µM -1.01875976700262 0.131594686162516 no 2932 0.154158515270436 4093 3807862
SGTC_723 4182-0001 115 µM -1.01928325483006 0.131471975861256 no 2933 0.154034255682914 4131 744821 YLR208W SEC13
SGTC_976 1348-1067 47.6 µM -1.0193278530823 0.131461525278571 no 2934 0.154023672521084 4121 5310671 YGL099W LSG1
SGTC_2350 9023895 38.85 µM -1.02168998232259 0.130908833614504 no 2935 0.153463826959616 4132 2997209
SGTC_44 0929-0055 61.211 µM -1.02338103918985 0.130514147253042 no 2936 0.153063860371245 4021 1379590
SGTC_2195 6536160 144.242 µM -1.02783885601258 0.129477656086234 no 2937 0.15201281761559 4068 3834386
SGTC_2094 5332512 191.667 µM -1.02851345314873 0.129321303089841 no 2938 0.151854182920644 4148 755774
SGTC_1339 1486-1321 22.7 µM -1.0289161090847 0.129228040944178 no 2939 0.151759548917084 4137 3469382
SGTC_2144 5628481 200 µM -1.02965331037838 0.129057413090322 no 2940 0.151586390143161 4093 2818399
SGTC_2797 7859098 81.82 µM -1.03194095898459 0.128528923485997 no 2941 0.151049888366576 4117 972681
SGTC_1169 aniline yellow 25.8 µM -1.03359251251181 0.128148318603769 no 2942 0.150663350604962 4048 6051 A DNA damaging agent.
SGTC_2278 7948257 134.34 µM -1.03378580491582 0.128103825079677 no 2943 0.150618154590039 4123 1247028
SGTC_968 1309-0633 340 µM -1.03709641106226 0.127343429884778 no 2944 0.149845463817442 4186 3761976
SGTC_654 1124-0271 80.9 µM -1.03719877187348 0.127319969325202 no 2945 0.149821615162004 4112 5403748
SGTC_2556 citropten 84.59 µM -1.03830588387195 0.127066417177075 no 2946 0.149563835132025 4155 2775 A potential DNA crosslinker.
SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM -1.03972311250144 0.126742354853982 no 2947 0.149234279728525 4112 803109
SGTC_2466 5983409 37.09 µM -1.04024865295163 0.126622331605701 no 2948 0.149112196463562 4143 2879657
SGTC_905 2-aminofluorene 215 µM -1.04121236529865 0.126402444120017 no 2949 0.148888499045027 4142 1539 An established DNA mutagen. YPR165W RHO1
SGTC_1917 st066507 28.5 µM -1.04133654178544 0.12637413048789 no 2950 0.148859691450326 4098 3156428
SGTC_1267 0828-0272 9.49 µM -1.04161077542484 0.126311617798175 no 2951 0.148796085424098 4215 745334
SGTC_2727 riluzole 51.77 µM -1.04195449201575 0.126233296617812 no 2952 0.148716389105544 4146 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.
SGTC_598 3937-0236 20.2 µM -1.04228837661736 0.126157248224468 no 2953 0.148638999818991 4194 1379313
SGTC_1574 spiramycin 23.7 µM -1.04398648201206 0.125770967578913 no 2954 0.148245821965066 4101 6419898 An antibiotic and protein synthesis inhibitor.
SGTC_1246 0422-0085 105 µM -1.04462662364816 0.125625564157141 no 2955 0.148097784876842 4175 264295
SGTC_3270 9137563 49.47 µM -1.05013616095776 0.124378961836024 no 2956 0.146827757640974 4125 17015724
SGTC_1207 2099-0101 141 µM -1.05351780062105 0.123618121240928 no 2957 0.146051870170774 4155 5837381
SGTC_1678 st019265 80.2 µM -1.05459439727021 0.123376581413611 no 2958 0.145805433650521 4157 5367020
SGTC_1668 st014914 51.6 µM -1.05540756168443 0.123194363236588 no 2959 0.145619483011446 4149 2839556
SGTC_2018 5133068 143 µM -1.05574432013329 0.12311895587878 no 2960 0.145542521373577 4101 785362
SGTC_2737 bleomycin 30.5 nM -1.05701117594781 0.12283556979249 no 2961 0.145253243457191 4190 16211318 Bleomycin acts by induction of DNA strand breaks.
SGTC_2758 dehydroepiandrosterone 69.35 µM -1.05797820622368 0.122619560481828 no 2962 0.145032689192143 4163 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem]
SGTC_1513 0337-0559 19 µM -1.06015686379314 0.12213388213941 no 2963 0.144536620881022 4120 775073
SGTC_3059 1327-0034 3 µM -1.06211719947595 0.121698029182322 no 2964 0.144091241441773 4039 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_250 brefeldin a 552.239 µM -1.06308139220122 0.121484056015774 no 2965 0.143872521077785 4020 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.
SGTC_2020 4017018 200 µM -1.06453641141679 0.121161659791414 no 2966 0.143542884365984 4210 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope.
SGTC_1351 1496-0003 46.5 µM -1.06735166710959 0.120539578592269 no 2967 0.142906532579983 4178 3891978
SGTC_328 k915-0120 63.5 µM -1.06916447103007 0.120140199417699 no 2968 0.142497782512217 4148 6624543
SGTC_296 1222-0039 74.9 µM -1.06990686284771 0.119976912358665 no 2969 0.142330616841885 4170 5984176
SGTC_7 0192-1582 4.227 µM -1.07138773498157 0.119651665953001 no 2970 0.141997562677135 4205 252616
SGTC_2751 anetholtrithion 17.25 µM -1.07388323146167 0.119104983804596 no 2971 0.141437509888707 4169 2194 A chloretic substance that stimulates the liver to produce bile.
SGTC_2201 6605497 169.863 µM -1.07527308292412 0.118801278203898 no 2972 0.141126241810041 4100 670741
SGTC_3171 9103192 49.47 µM -1.07618287812061 0.118602769340252 no 2973 0.140922737813532 4231 13018434
SGTC_2467 5474540 200 µM -1.07687825544068 0.118451202580922 no 2974 0.140767329327485 4123 5413519
SGTC_444 curcumin 90.4 µM -1.07899981438473 0.117989626698472 no 2975 0.140293905199097 4110 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties.
SGTC_477 mead ethanolamide 10 µM -1.07909792932803 0.117968311195791 no 2976 0.140272037121815 4081 16061185
SGTC_2268 7933382 153.85 µM -1.08439995554069 0.116820492956291 no 2977 0.139093751722114 4204 935025 YOR257W CDC31
SGTC_473 2-arachidonoylglycerol 10 µM -1.08456122624842 0.116785704489613 no 2978 0.139058017931445 4012 5282280 An endocannabinoid.
SGTC_1932 st074806 40.9 µM -1.08547455941862 0.11658882364733 no 2979 0.138855762726427 4255 17251235
SGTC_1271 0832-2808 169 µM -1.08842126167316 0.115955228757254 no 2980 0.138204589567127 4211 3663794
SGTC_1204 4049-0315 18.3 µM -1.0903630413188 0.115539049115367 no 2981 0.137776627723615 4236 588402
SGTC_1680 diphenhydramine 100 µM -1.09058495795908 0.115491553610396 no 2982 0.13772777566533 4170 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1
SGTC_864 0469-0573 172 µM -1.09327245591012 0.114917465431543 no 2983 0.137137096333637 4174 689425
SGTC_356 1634-0012 32.5 µM -1.09654457588426 0.114221237434537 no 2984 0.136420263554552 4205 735457
SGTC_668 1682-0499 62.6 µM -1.0980806995694 0.113895425668688 no 2985 0.136084626155064 4166 682214
SGTC_3001 9076041 71.4286 µM -1.09914442119079 0.113670198774572 no 2986 0.135852538366453 4168 16004211
SGTC_2127 5253358 187.912 µM -1.1000435932337 0.113480060524529 no 2987 0.135656564293217 4089 20612
SGTC_1649 st011737 51.3 µM -1.10120715391097 0.113234351636231 no 2988 0.135403254427684 4198 1761035
SGTC_1129 3453-1384 223 µM -1.10272229841597 0.112914968080835 no 2989 0.135073890120545 4284 1084452
SGTC_2627 acetyl isogambogic acid 100 µM -1.10762204711067 0.111886533395556 no 2990 0.13401253889273 4224 6857789 A caspase activator and apoptosis inducer.
SGTC_2575 plumbagin 510 nM -1.11044412457262 0.111297241304677 no 2991 0.133403846564612 4124 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_276 colchicine 750 µM -1.11116413947876 0.111147247793325 no 2992 0.133248851933747 4270 2833 A microtubule depolymerizer.
SGTC_2358 9037157 4 µM -1.11404419612404 0.110548721927907 no 2993 0.132630113405598 4210 2388925
SGTC_1460 k062-0059 9.15 µM -1.11565248558401 0.110215498428302 no 2994 0.132285458195124 4091 1373085
SGTC_2070 5230947 200 µM -1.11606367192056 0.110130419975873 no 2995 0.132197440460154 4302 2835538
SGTC_3348 9149464 3.537 µM -1.11719991915409 0.109895564363315 no 2996 0.131954427589542 4163 1951442
SGTC_3137 9097352 49.47 µM -1.11838826733259 0.109650324542177 no 2997 0.131700601536833 4248 44120435
SGTC_2958 9077254 16.72 µM -1.11964259783105 0.109391894438275 no 2998 0.13143304765967 4288 16457351
SGTC_2137 5261020 140 µM -1.12205966327982 0.108895140073326 no 2999 0.13091853644122 4169 763655
SGTC_1824 st053723 68.6 µM -1.12436055922681 0.10842376945218 no 3000 0.13043004843656 4254 675225
SGTC_826 1683-5028 118 µM -1.12458229776203 0.108378420898647 no 3001 0.130383039280663 4258 722377
SGTC_834 0312-0008 75.7 µM -1.12788210396664 0.107705177773111 no 3002 0.129684856366372 4225 6385573 YIL048W NEO1
SGTC_1845 st056753 3.01 µM -1.12823754986252 0.107632838055576 no 3003 0.129609804830109 4189 5375839
SGTC_3328 9140624 29.0385 µM -1.12941312656482 0.107393836141742 no 3004 0.129361798994361 4236 4904392
SGTC_775 4577-0580 57.3 µM -1.13065627098119 0.107141513714087 no 3005 0.129099896691888 4277 2006902
SGTC_518 1021-0119 62.6 µM -1.13088231514421 0.107095679248121 no 3006 0.129052313848553 4185 1097762
SGTC_367 0335-0881 7.1 µM -1.13288622998901 0.106689968205476 no 3007 0.128631016666914 4182 23828853
SGTC_446 go6976 132 µM -1.13518726036603 0.106225472897931 no 3008 0.128148433075706 4255 3501 A protein kinase C inhibitor.
SGTC_1407 3909-7909 12.3 µM -1.13609328525673 0.106042980426332 no 3009 0.127958762483758 4227 4411780
SGTC_1335 1486-0900 202 µM -1.13736381969243 0.105787449789079 no 3010 0.12769311279218 4214 X1335
SGTC_2158 5657123 3.6195 µM -1.13740333259767 0.105779510072883 no 3011 0.127684857387482 4194 2858827
SGTC_1578 josamycin 24.2 µM -1.14141786136228 0.104975075134086 no 3012 0.126848037663631 4235 5282165 A P450 substrate.
SGTC_3077 9117319 49.47 µM -1.14296115658699 0.104667009647719 no 3013 0.126527359432388 4219 17154678
SGTC_2880 9042983 58.44 µM -1.14470589807226 0.104319521587617 no 3014 0.126165503695877 4214 6464714
SGTC_2862 9027634 71.43 µM -1.14529072408955 0.104203233146423 no 3015 0.126044373580482 4196 5012562
SGTC_756 0508-1999 28.3 µM -1.14661409077597 0.103940438165352 no 3016 0.12577057511231 4250 6753853
SGTC_3237 9133362 49.47 µM -1.14857392068156 0.103552137402282 no 3017 0.125365857940425 4222 43845137
SGTC_1579 chlormadinone acetate 49.4 µM -1.14955918247114 0.103357325773837 no 3018 0.125162738965271 4284 45114258 A steroidal progestin.
SGTC_1694 st024011 44.9 µM -1.15151458845431 0.10297147993616 no 3019 0.124760298541329 4270 2787533
SGTC_118 0083-0097 135.343 µM -1.15348709900775 0.102583320211461 no 3020 0.124355254896787 4236 5207356
SGTC_2131 toluylene red 5.2905 µM -1.15424253451312 0.102434944166267 no 3021 0.124200374392694 4213 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain.
SGTC_683 panaxydol 45 µM -1.15711005477964 0.101873151298657 no 3022 0.123613699600614 4237 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis.
SGTC_3078 9116413 49.47 µM -1.15742315350178 0.101811946337687 no 3023 0.123549759480724 4167 17177322
SGTC_2819 7996655 46.38 µM -1.15943158655207 0.101419971604563 no 3024 0.123140153916357 4204 6456960
SGTC_633 0437-0093 97.7 µM -1.1606451110251 0.101183668153105 no 3025 0.12289312603878 4193 2831118
SGTC_2658 polymyxin b sulfate 77.05 µM -1.16769505927027 0.0998188002220874 no 3026 0.121464895225683 4278 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides. YIL048W NEO1
SGTC_2531 methyl deoxycholate 70.07 µM -1.16806012172072 0.0997484922543577 no 3027 0.121391257249626 4207 16667744 Haematoxylin.
SGTC_913 3487-1245 167 µM -1.17030968231604 0.0993160439645587 no 3028 0.120938183433469 4203 4016153
SGTC_373 0844-0104 25.9 µM -1.17445144063524 0.0985234336344071 no 3029 0.120107125643243 4277 5375804
SGTC_1894 3',6'-dihydroxyflavone 78.7 µM -1.17448411528989 0.0985171991350788 no 3030 0.120100585403151 4253 688662
SGTC_3009 9080819 71.4286 µM -1.1752439211353 0.0983723055454508 no 3031 0.119948571546423 4283 17027216
SGTC_1440 4100-1550 40 µM -1.17532366781387 0.0983571070531427 no 3032 0.11993262454902 4258 742806
SGTC_253 dyclonine 31.25 µM -1.18040471084443 0.0973922803491015 no 3033 0.118919644610822 4374 3180 An oral anasthetic.
SGTC_1176 0848-0131 83.3 µM -1.18060473586907 0.0973544406358469 no 3034 0.118879890698939 4318 6769040
SGTC_2008 4012253 172 µM -1.18090946674576 0.0972968139375921 no 3035 0.118819345097872 4263 603940
SGTC_2850 9015429 58.44 µM -1.18265798730104 0.0969666404410283 no 3036 0.118472360483154 4284 6457570
SGTC_2324 6149169 200 µM -1.18270500942141 0.0969577726156904 no 3037 0.118463039092394 4171 2888231
SGTC_2508 celastrol 40.54 µM -1.18341385905897 0.096824163941577 no 3038 0.118322583679853 4202 122724 Celastrol is a natural product and antioxidant.
SGTC_1238 0333-0287 48.8 µM -1.18478397822549 0.0965662980992365 no 3039 0.118051434439534 4251 7226
SGTC_3317 9138495 8.753 µM -1.18749670142749 0.0960572339193719 no 3040 0.117515878460948 4187 17020139
SGTC_1402 3909-7673 35.9 µM -1.19108781318067 0.0953863718699444 no 3041 0.116809556783907 4297 5328014
SGTC_1388 3346-4487 254 µM -1.19224655432066 0.0951706430656849 no 3042 0.116582292037291 4339 3345614
SGTC_1505 k297-0037 20.6 µM -1.19447367524183 0.0947570178187749 no 3043 0.116146366110496 4275 4089396
SGTC_1086 cerivastatin 2.18 µM -1.19639522076766 0.0944012105225559 no 3044 0.115771182747052 4272 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7
SGTC_38 0929-0051 58.268 µM -1.19656828791168 0.0943692125835009 no 3045 0.115737433543855 4265 1379719
SGTC_1695 st026914 34.495 µM -1.19697275125525 0.0942944635859369 no 3046 0.115658587846671 4271 3289191
SGTC_31 0508-1974 57.237 µM -1.19745006942465 0.0942063064515448 no 3047 0.115565588991722 4207 6810525
SGTC_3082 9117008 49.47 µM -1.20002750052186 0.0937313243115973 no 3048 0.115064330091973 4329 41448529
SGTC_1149 3909-7961 23.3 µM -1.20130167568024 0.0934971669180305 no 3049 0.114817100337645 4335 735261
SGTC_2711 st079103 59.1 µM -1.20215676017649 0.0933402689797391 no 3050 0.114651399295495 4231 54693780
SGTC_1381 2324-0066 62.1 µM -1.20437624824015 0.0929339268732393 no 3051 0.114222094019481 4322 10885928
SGTC_2477 5967686 25.23 µM -1.20578264797266 0.0926771221031544 no 3052 0.113950653888593 4272 776118
SGTC_1374 2889-5571 141 µM -1.20920103104897 0.0920551235206113 no 3053 0.113292810854985 4330 2853281
SGTC_1518 st038567 90.8 µM -1.20920860822775 0.0920537482419211 no 3054 0.113291355697317 4228 77966
SGTC_22 0964-0034 14.468 µM -1.21077555971225 0.0917696690217514 no 3055 0.112990717249188 4301 138402
SGTC_825 1988-2224 89.6 µM -1.21094784423241 0.0917384745078901 no 3056 0.112957697173396 4280 1180859
SGTC_1960 st011366 51.8 µM -1.21121969466133 0.0916892681765626 no 3057 0.112905608290738 4310 3972846
SGTC_1759 st043059 70 µM -1.21135970408475 0.0916639333781737 no 3058 0.112878787970186 4294 669426
SGTC_1284 0929-0043 16 µM -1.21138793235581 0.0916588260820717 no 3059 0.112873381090284 4303 1239883
SGTC_3338 9144300 39.5675 µM -1.21193107300975 0.0915605975626202 no 3060 0.112769383220621 4294 4901274
SGTC_2787 5284540 71.43 µM -1.22422979423516 0.0893571750893854 no 3061 0.110432776317747 4331 736958
SGTC_1400 3771-8998 51.5 µM -1.22543376320535 0.0891436117783811 no 3062 0.110205916131707 4236 670767
SGTC_2331 7980721 200 µM -1.2257109893066 0.0890944904983548 no 3063 0.110153726645189 4251 2981221
SGTC_2667 digitoxin 100 µM -1.22705236308789 0.0888570989961733 no 3064 0.109901455350559 4238 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_2865 9030313 51.95 µM -1.22724016923069 0.0888238993612228 no 3065 0.109866167886899 4281 42562754
SGTC_2520 obtusaquinone 4.71 µM -1.22840754413833 0.0886177425021248 no 3066 0.109647008639551 4349 5967872
SGTC_2610 ononetin 44.17 µM -1.22968047761516 0.0883933505707741 no 3067 0.10940839008972 4283 259632
SGTC_1618 st003135 44.5 µM -1.23155281724255 0.088064065461531 no 3068 0.10905808763385 4283 1270615
SGTC_3060 1327-0027 12.5 µM -1.23561105516979 0.0873534910948912 no 3069 0.108301586691828 4233 16000455 YPR107C YTH1
SGTC_377 3970-0964 33.1 µM -1.2360293367452 0.0872804963781487 no 3070 0.10822382954065 4272 16481235
SGTC_1771 st048882 4.1505 µM -1.23626923642399 0.0872386518106702 no 3071 0.108179251125813 4358 4580403
SGTC_2311 7694451 200 µM -1.23914339649537 0.0867384898184199 no 3072 0.107646199142841 4302 2163142
SGTC_1677 st019204 53.9 µM -1.24014581072533 0.0865645544339297 no 3073 0.10746073367324 4342 3945625
SGTC_492 tmb-8 126 µM -1.24097455372977 0.0864209508591337 no 3074 0.107307574642264 4299 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1
SGTC_631 k072-0230 41.5 µM -1.24502826024162 0.0857210952170678 no 3075 0.106560681204932 4318 5773147
SGTC_1770 st043884 66.3 µM -1.25004789000013 0.0848603673859083 no 3076 0.10564102686394 4334 670149
SGTC_744 1594-0068 283 µM -1.25030123692777 0.0848170977852826 no 3077 0.105594763375952 4298 668392
SGTC_89 0302-0250 142.109 µM -1.25202421476279 0.0845232658600904 no 3078 0.105280520296209 4422 4203518 YLR208W SEC13
SGTC_1637 st007924 17.4 µM -1.25260589723337 0.0844242399368704 no 3079 0.105174583813929 4233 683336
SGTC_645 0845-0943 5.41 µM -1.25531756487746 0.0839637527608844 no 3080 0.104681750642487 4339 1885106
SGTC_594 1487-1584 10.8 µM -1.25612499774323 0.0838270020309803 no 3081 0.104535327095661 4278 5013332
SGTC_1681 tripelennamine 100 µM -1.25647198444256 0.083768286105496 no 3082 0.104472448553142 4260 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist.
SGTC_269 exalamide 29 µM -1.25922272880726 0.0833039071261333 no 3083 0.103974947090706 4269 3316 A derivative of salicylamide.
SGTC_652 0437-0092 114 µM -1.26223925737585 0.0827968863690002 no 3084 0.103431353256105 4274 3091274
SGTC_2845 9003024 42.97 µM -1.26369892622249 0.0825523791536983 no 3085 0.10316905534376 4383 2990173
SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM -1.26419197343539 0.0824699123828794 no 3086 0.103080565537775 4310 2724278 An inhibitor of dopamine biosynthesis.
SGTC_782 0083-0095 30.5 µM -1.26456832378656 0.0824070060074289 no 3087 0.103013057046623 4298 3591729 An indicator and reagent.
SGTC_337 1315-0038 354 µM -1.2675173506447 0.0819153309184383 no 3088 0.102485181806186 4314 1626437
SGTC_199 4063-0024 41.6 µM -1.26804091094253 0.0818282721340649 no 3089 0.102391670559238 4369 306215
SGTC_3284 9108171 64.8615 µM -1.2698012482734 0.081536070664537 no 3090 0.102077717988035 4320 8687505
SGTC_1733 st037357 54.9 µM -1.26987317724771 0.0815241478021725 no 3091 0.102064904512956 4251 1272339 YGL099W LSG1
SGTC_801 0866-0028 10.1 µM -1.270243148665 0.0814628425461015 no 3092 0.101999016050231 4352 6849771
SGTC_2562 3',7'-dimethoxyflavone 64.92 µM -1.27068301301757 0.0813900010916066 no 3093 0.101920720588476 4437 688664
SGTC_3122 9126309 49.47 µM -1.27445123608147 0.0807679959893239 no 3094 0.101251772057081 4419 17591206
SGTC_979 1426-2828 121 µM -1.27529003698002 0.0806300282627438 no 3095 0.101103301408591 4432 747872
SGTC_1406 3909-7906 11.9 µM -1.27616052167573 0.080487037406803 no 3096 0.100949390461353 4374 X1406
SGTC_480 am 92016 50 µM -1.28476394924654 0.0790840761873964 no 3097 0.099437391864547 4372 2129 K+ channel blocker.
SGTC_236 1509-0011 5.31 µM -1.28478713530441 0.0790803204204809 no 3098 0.0994333395487739 4392 3107280
SGTC_2619 obliquin 87.91 µM -1.28601626777805 0.0788814141312021 no 3099 0.0992186921589964 4313 6708593 A bioactive alkalod. YER133W GLC7
SGTC_1373 2887-0003 58.5 µM -1.2881111412342 0.0785432817451299 no 3100 0.0988536388025808 4301 776948
SGTC_1696 st025591 34.7925 µM -1.28958978078672 0.0783052775666691 no 3101 0.0985965628711384 4359 2787147
SGTC_21 0849-0113 22.993 µM -1.29002524122634 0.0782352895149228 no 3102 0.0985209471874772 4323 1560156
SGTC_3167 9103034 49.47 µM -1.29435870279926 0.0775413902366323 no 3103 0.0977707741581658 4442 5127859
SGTC_2971 9092186 9.93 µM -1.29747843700389 0.0770447404591184 no 3104 0.0972333098476485 4326 25236400
SGTC_2700 st077718 96.8 µM -1.29818683000332 0.0769323045313721 no 3105 0.0971115712952053 4350 904970
SGTC_1521 st012942 49.4 µM -1.29837719971346 0.0769021103805931 no 3106 0.0970788750123557 4307 24207259
SGTC_1259 0671-0132 43 µM -1.2991166432584 0.0767849141995364 no 3107 0.0969519511196951 4288 X1259
SGTC_702 1488-0190 94 µM -1.29938202864431 0.0767428857643253 no 3108 0.0969064280098225 4399 949357
SGTC_3231 9132313 49.47 µM -1.30166225961634 0.0763824916977916 no 3109 0.0965159331862774 4301 4905967
SGTC_2366 9070441 60.58 µM -1.30168531941443 0.0763788536492983 no 3110 0.0965119900559839 4333 6837235
SGTC_3112 9123419 49.47 µM -1.30588873583408 0.0757178980661823 no 3111 0.0957951988578513 4422 17015854
SGTC_1158 4092-0494 91.8 µM -1.3060508932722 0.0756924875884699 no 3112 0.0957676254839643 4441 1148199
SGTC_2212 7123476 200 µM -1.30694836387073 0.0755519691487556 no 3113 0.0956151244751321 4379 1085715
SGTC_2034 5197015 53.07 µM -1.3112122653904 0.0748870773583641 no 3114 0.0948930298123536 4367 780676
SGTC_386 1509-0011 3.07 µM -1.31214004576185 0.074742996935668 no 3115 0.0947364431890847 4383 3107280
SGTC_800 3448-7362 155 µM -1.31450697788368 0.0743763804633447 no 3116 0.0943378257152399 4448 15991913
SGTC_1676 st018489 23.4 µM -1.31610917370966 0.0741289951017959 no 3117 0.0940687011779567 4383 3696235
SGTC_1166 k206-0078 225 µM -1.31883339417312 0.0737098082984238 no 3118 0.0936124087013323 4404 5404595
SGTC_2922 7999257 32.47 µM -1.31904374174217 0.0736775167795587 no 3119 0.0935772446866891 4352 2988377
SGTC_158 k038-0087 26.446 µM -1.31906285040367 0.0736745838482396 no 3120 0.0935740507558961 4283 X158
SGTC_1295 1013-0063 9.78 µM -1.32076074702909 0.0734143349132305 no 3121 0.0932905758900619 4407 6826038
SGTC_1792 st045773 43.6 µM -1.32206244565278 0.073215290713181 no 3122 0.0930736789001102 4343 2919270
SGTC_1398 3558-0053 112 µM -1.32590207414732 0.0726305737634175 no 3123 0.0924360679433368 4338 4532369
SGTC_1037 k284-1091 78.7 µM -1.32825187058465 0.0722745036600361 no 3124 0.0920474568911451 4357 3334711
SGTC_973 1325-0077 65.9 µM -1.32958293870861 0.07207339819016 no 3125 0.091827861265722 4391 2835149
SGTC_1766 st045414 44.774 µM -1.33185613659416 0.0717309425701636 no 3126 0.0914537335338875 4394 253960
SGTC_697 0508-1955 564 µM -1.33398478384828 0.0714113963240498 no 3127 0.0911044216749648 4384 6243113
SGTC_754 3474-0146 171 µM -1.33718045202221 0.0709337248309265 no 3128 0.0905818705574033 4383 24762078
SGTC_1806 st050005 60.3 µM -1.33979492220561 0.0705447562280756 no 3129 0.0901560134773271 4451 5194765
SGTC_1446 4239-0190 62 µM -1.35613308061669 0.068151075453082 no 3130 0.0875284145921105 4415 1340085
SGTC_2939 9044578 71.43 µM -1.35667411497241 0.0680728952050812 no 3131 0.0874423903709577 4335 2653634
SGTC_232 clozapine 119 µM -1.35681574019793 0.06805244159343 no 3132 0.0874198824479705 4415 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_416 estradiol valerate 100 µM -1.36507912394025 0.0668672331449791 no 3133 0.0861140913106205 4416 13791 A steroid.
SGTC_1160 4092-0570 10.5 µM -1.36621174648237 0.066706034359812 no 3134 0.0859362558325931 4416 4994975
SGTC_609 0986-0026 86.3 µM -1.36756247746586 0.06651418697979 no 3135 0.0857245341617937 4383 2848610
SGTC_1837 st055472 66.5 µM -1.36806551968878 0.0664428480097403 no 3136 0.0856457841822933 4464 676091
SGTC_2325 6158266 200 µM -1.37120985344279 0.0659982756977852 no 3137 0.0851547737202614 4407 3623240
SGTC_3216 9129716 49.47 µM -1.37551750077829 0.0653929703176474 no 3138 0.0844855319205743 4346 8056934
SGTC_1319 1306-0155 43.7 µM -1.37927016738819 0.0648691676771536 no 3139 0.083905735485226 4462 3122360
SGTC_1171 0368-0077 21.4 µM -1.37997885743899 0.0647706143679257 no 3140 0.0837965773235428 4407 3239779
SGTC_1914 st062367 72.6 µM -1.38042018522328 0.0647093003086299 no 3141 0.0837286543725457 4402 978205
SGTC_1001 4048-4355 44.4 µM -1.38057867830697 0.0646872917282132 no 3142 0.083704271447758 4414 21824233
SGTC_951 1171-0579 82.7 µM -1.38080059368436 0.064656486004458 no 3143 0.0836701404615058 4364 1616050 YPR165W | YDR526C RHO1 | YDR526C
SGTC_799 1310-0557 151 µM -1.38231971309283 0.0644459116153175 no 3144 0.0834367778690187 4443 5354492
SGTC_786 4544-0069 423 µM -1.38282033415996 0.0643766343344654 no 3145 0.0833599812202738 4406 748821 YLR208W SEC13
SGTC_138 0850-0259 40.9225 µM -1.38646627700135 0.063873843064002 no 3146 0.0828022853876004 4354 6813004
SGTC_2200 6600604 21.907 µM -1.38765782488358 0.0637101872922548 no 3147 0.0826206321762815 4459 2904777
SGTC_1127 asiatic acid 681.4 nM -1.39053059161388 0.0633169621803167 no 3148 0.0821839082321614 4387 470603 A kinase inhibitor which arrests cells at G2/M.
SGTC_1785 bathophenanthroline 24 µM -1.39081385424414 0.0632782916750768 no 3149 0.0821409404173137 4358 72812 An iron chelator.
SGTC_2277 7947813 106.88 µM -1.39101138826953 0.0632513355691232 no 3150 0.0821109867022739 4456 1246798
SGTC_3088 9117578 49.47 µM -1.39108865684887 0.0632407936920475 no 3151 0.0820992720688475 4490 678341
SGTC_2560 caryophyllene 100 µM -1.39331275620852 0.0629379422390681 no 3152 0.0817626174324636 4459 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor.
SGTC_1107 amlodipine 47 µM -1.39336745952215 0.0629305076524356 no 3153 0.0817543503023525 4036 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.
SGTC_375 3970-0961 9.27 µM -1.39506112583681 0.062700664155485 no 3154 0.0814987037826947 4396 2898222
SGTC_2401 5128683 200 µM -1.39576679383846 0.0626050929011916 no 3155 0.0813923664631744 4431 708373
SGTC_2505 galangin 7.89 µM -1.39725864692764 0.0624034194776556 no 3156 0.0811679032178067 4324 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_2108 5365811 200 µM -1.3992810723584 0.0621308309126167 no 3157 0.0808643566277992 4438 780283
SGTC_785 1270-0111 65.3 µM -1.40205530346277 0.0617584238923697 no 3158 0.0804493663897349 4356 6741994
SGTC_622 1348-1566 26.3 µM -1.40336517370407 0.0615831963411486 no 3159 0.0802539862905063 4428 7340407
SGTC_2345 9052315 157.45 µM -1.40544658994141 0.0613055543463506 no 3160 0.0799442604482999 4447 6469265
SGTC_2696 st077691 74.316 µM -1.40784846952265 0.060986381934731 no 3161 0.0795879722552961 4456 757133
SGTC_3035 9091303 49.47 µM -1.40899593143594 0.0608343613441417 no 3162 0.0794181855925912 4517 25237002
SGTC_931 2812-0076 566 µM -1.40998825157592 0.0607031336579503 no 3163 0.0792715759875146 4361 3450959
SGTC_952 1185-0122 232 µM -1.41110289203762 0.060555994063444 no 3164 0.0791071386963221 4390 678600
SGTC_1073 triclabendazole 3.09 µM -1.41296671732084 0.0603105808651363 no 3165 0.0788327552068413 4471 50248 An antihelmetic and likely tubulin inhibitor.
SGTC_2340 7987427 183.45 µM -1.41495302472515 0.0600498977942073 no 3166 0.0785411347968148 4450 2239331
SGTC_3004 9076122 71.4286 µM -1.41622164941803 0.0598838656873605 no 3167 0.078355309595613 4449 44782551
SGTC_2515 chrysin 20.77 µM -1.41735960592077 0.0597352409891208 no 3168 0.0781889081740789 4450 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor.
SGTC_442 cape 100 µM -1.41892098300039 0.0595317852386835 no 3169 0.0779610270570751 4456 5281787
SGTC_2163 5671233 125 µM -1.42271891221957 0.059039162076299 no 3170 0.0774088279556907 4406 701023
SGTC_575 k072-0246 11.9 µM -1.42754168403295 0.0584182234585999 no 3171 0.0767119095147935 4537 6796779
SGTC_1479 0549-0158 134 µM -1.42754706129486 0.058417534002179 no 3172 0.0767111351410856 4505 5440202
SGTC_501 nsc-95397 161 µM -1.42764617026326 0.0584048276912715 no 3173 0.0766968636294882 4457 262093
SGTC_1318 1280-3875 124 µM -1.42837539702701 0.0583114035647573 no 3174 0.0765919183742246 4452 373245
SGTC_1935 st074532 41.6 µM -1.42861109331558 0.0582812326945109 no 3175 0.0765580219659951 4416 2829742
SGTC_2263 7948595 193.29 µM -1.43163487825739 0.0578952527025377 no 3176 0.0761241712053814 4470 2971371
SGTC_1161 k007-0610 110 µM -1.43312641373608 0.057705602706237 no 3177 0.0759108570903793 4393 5843850
SGTC_2130 NSC 7 2.4545 µM -1.43667242408842 0.0572566857202561 no 3178 0.0754055470124876 4507 21448
SGTC_946 3434-1334 87.4 µM -1.44303952481414 0.056457527531244 no 3179 0.0745046687219384 4431 4047976
SGTC_2947 9072639 7.68 µM -1.44536797788384 0.0561674796559247 no 3180 0.074177276508431 4411 16488146
SGTC_247 mechlorethamine 29.705 µM -1.45768262255752 0.0546529763401353 no 3181 0.0724640219870424 4429 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links.
SGTC_630 4356-0227 183 µM -1.45902823134749 0.0544894637999871 no 3182 0.0722786688049031 4416 779312
SGTC_879 0831-1030 162 µM -1.46254180941189 0.054064332910617 no 3183 0.0717963979957603 4473 1549252
SGTC_3130 9127414 49.47 µM -1.46360252263367 0.0539365074730535 no 3184 0.0716512914529871 4500 1494646
SGTC_2087 5276107 200 µM -1.46664533771478 0.0535711483987893 no 3185 0.0712362799561049 4443 144405
SGTC_2295 7971645 200 µM -1.46834263678344 0.053368202574816 no 3186 0.0710055874255368 4528 2978226 YKL099C UTP11
SGTC_474 dl-dihydrosphingosine 5 µM -1.47609705996731 0.05244874713065 no 3187 0.0699589190282378 4477 3058739 A sphingolipid protein kinase C inhibitor.
SGTC_2024 5144227 134 µM -1.47797714456277 0.0522277271678301 no 3188 0.0697069479297253 4451 3475211
SGTC_2745 rifampicin 24.3 µM -1.47847802085227 0.0521689698426927 no 3189 0.0696399379050991 4578 25141428 Inhibits bacterial DNA-dependent RNA polymerase.
SGTC_2476 5806916 10.51 µM -1.4818185363194 0.0517784387708776 no 3190 0.0691942927750686 4404 2870194
SGTC_2952 9073731 13.78 µM -1.49003486473496 0.0508277724152409 no 3191 0.0681075344738165 4486 16457353
SGTC_1776 st049249 45.9 µM -1.4915721397712 0.0506514557912365 no 3192 0.0679056731961848 4499 1822314
SGTC_1189 1431-2119 7.28 µM -1.50329399150062 0.0493229952707057 no 3193 0.0663816244307948 4479 3107275
SGTC_61 0978-8327 98.565 µM -1.50347242995366 0.0493029895523382 no 3194 0.0663586306295114 4419 6150059 YHR072W ERG7
SGTC_665 3914-0008 307 µM -1.50413124582815 0.0492291821884729 no 3195 0.0662737882140675 4464 1069549
SGTC_42 0133-0086 60.653 µM -1.50949771627937 0.0486312563070191 no 3196 0.0655858192332323 4387 162923 Model of phenazepam hydroxylation.
SGTC_3113 9123498 49.47 µM -1.50994148305598 0.0485820733579378 no 3197 0.0655291781831381 4596 8897275
SGTC_2710 st078562 53.7235 µM -1.50998930425846 0.0485767756787207 no 3198 0.0655230766942004 4454 17250908
SGTC_872 0588-0139 234 µM -1.51007897149855 0.0485668434998158 no 3199 0.0655116372728383 4457 2047100
SGTC_2682 pyrogallin 40.03 µM -1.51219546090947 0.0483328772548866 no 3200 0.0652420727118378 4503 822798 An ATP competetive kinase inhibitor.
SGTC_1444 4112-3581 28 µM -1.51224209049946 0.0483277327787378 no 3201 0.0652361434841163 4581 2877249
SGTC_3306 9127676 59.7925 µM -1.51423732559328 0.0481080156499963 no 3202 0.0649828290251784 4468 41905287
SGTC_2502 avocadyne acetate 18.59 µM -1.51668325804985 0.047839758708658 no 3203 0.0646733366227288 4446 3952079
SGTC_2923 7992654 58.14 µM -1.51959565527385 0.0475219057974234 no 3204 0.0643063152684764 4490 2985126
SGTC_2235 salicylic acid 500 µM -1.53278646874173 0.0461034142018798 no 3205 0.0626642378436379 4573 338 A COX inhibitor and kinase inhibitor.
SGTC_1684 st024538 14.6195 µM -1.53328343401996 0.04605064449517 no 3206 0.0626030172542678 4483 6732859
SGTC_91 0417-1751 58.384 µM -1.53801786133169 0.045550353867238 no 3207 0.062022123815574 4602 6795624
SGTC_1341 1486-1360 280 µM -1.53845019884355 0.0455048870244266 no 3208 0.0619692881697916 4509 3976547
SGTC_1730 st033808 45.1 µM -1.53971893542905 0.0453716707990247 no 3209 0.061814439583642 4438 1045166
SGTC_1848 st056003 16.4 µM -1.54004577373551 0.0453374039246942 no 3210 0.0617745981182929 4524 146492
SGTC_3005 9076496 71.4286 µM -1.54456677705076 0.0448655383424605 no 3211 0.061225543711625 4487 21368410
SGTC_1802 st050112 57.9 µM -1.54982981319283 0.0443212146325168 no 3212 0.06059118464467 4530 4662563
SGTC_819 1013-0258 27.7 µM -1.55116477612525 0.0441839971259113 no 3213 0.0604311005217757 4519 5753198
SGTC_1739 st037196 92.5 µM -1.55192139816029 0.044106378018208 no 3214 0.0603405160902992 4530 612214
SGTC_2069 5228469 200 µM -1.57415780379524 0.0418739027431477 no 3215 0.0577254859094431 4529 2835210
SGTC_1532 4',5'-dihydroxyflavone 78.7 µM -1.57568095180333 0.0417243932585196 no 3216 0.0575496747226738 4586 165521
SGTC_399 oxolinic acid 75 µM -1.58596425740619 0.0407262811396607 no 3217 0.0563737089044644 4514 4628 A DNA gyrase inhibitor.
SGTC_55 0767-0285 6.563 µM -1.58705350554617 0.040621701673318 no 3218 0.0562502634636513 4464 3116166
SGTC_2112 5488546 200 µM -1.58972943792531 0.0403657088502673 no 3219 0.0559479025630478 4499 600757
SGTC_86 0417-1630 471.922 µM -1.58998426539334 0.0403413992733756 no 3220 0.0559191758980113 4538 3634867
SGTC_1885 st057546 99.9 µM -1.59146023280547 0.0402008313221739 no 3221 0.0557530191022657 4573 702008
SGTC_167 3672-0051 66.205 µM -1.59605611418538 0.0397656760429606 no 3222 0.0552381328053443 4460 3237971
SGTC_135 0933-0004 26.348 µM -1.5994659015107 0.0394453054771928 no 3223 0.0548585596673143 4471 21230617 YGL099W LSG1
SGTC_608 k048-0125 159 µM -1.60348510052557 0.0390703764137134 no 3224 0.0544137980080481 4593 6817652 YLR060W | YFL022C FRS1 | FRS2
SGTC_496 calpeptin 138 µM -1.61297456613398 0.0381966603615104 no 3225 0.053375016789517 4538 73364 A calpain inhibitor.
SGTC_2714 st079313 56.9 µM -1.61831004930824 0.0377124505801734 no 3226 0.0527978980286288 4542 2939799
SGTC_900 1112-0045 141 µM -1.61943345649058 0.0376111395365955 no 3227 0.0526770165984453 4465 56211 YIL048W NEO1
SGTC_1355 1499-0035 1.68 µM -1.62925977811214 0.0367344227593114 no 3228 0.0516290185150449 4555 1548538
SGTC_2659 sanguinarine 24.21 µM -1.63368895304157 0.0363447477615173 no 3229 0.0511620895570816 4526 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis.
SGTC_2312 7706453 155.7 µM -1.63443397001107 0.0362795354266951 no 3230 0.0510838801393719 4544 976098
SGTC_462 ag-879 158 µM -1.63508126356285 0.0362229547449469 no 3231 0.0510160066740965 4569 6809654 Ag-879 is a 5-Lipoxygenase inhibitor.
SGTC_794 k038-0031 316 µM -1.63643309166448 0.0361050228561289 no 3232 0.0508744890972901 4544 6624242
SGTC_2569 tetrandrine 100 µM -1.63897689074642 0.0358839573660644 no 3233 0.0506090362977607 4556 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_2027 5150920 200 µM -1.64303720017591 0.0355334001008785 no 3234 0.0501876183750097 4519 786715
SGTC_908 3448-7491 47.7 µM -1.64629318320013 0.0352543192278185 no 3235 0.0498517061344802 4570 1203031
SGTC_2630 antimycin a 100 µM -1.64760387586112 0.0351424842542178 no 3236 0.0497169922863664 4493 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain.
SGTC_525 k781-2675 26.7 µM -1.64809924274422 0.0351002928950911 no 3237 0.0496661538459472 4508 3651118 YDL195W SEC31
SGTC_1441 4106-0040 13 µM -1.65743781375258 0.0343126562256886 no 3238 0.0487154958448168 4628 2904180
SGTC_2192 5915882 198.485 µM -1.65923205274108 0.0341630020641866 no 3239 0.0485345205416581 4565 2876149
SGTC_1959 st077091 55.8 µM -1.66256768835047 0.0338862090328122 no 3240 0.0481995017516581 4569 821356 YKL052C ASK1
SGTC_2647 atorvastatin 60.16 µM -1.66726815705647 0.0334992951776606 no 3241 0.0477305477149965 4565 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7
SGTC_3138 9097216 49.47 µM -1.66983427802401 0.0332896071243005 no 3242 0.0474760781961518 4496 25237486
SGTC_1298 1079-1278 263 µM -1.6736984843076 0.0329758878223478 no 3243 0.0470949359149841 4552 2840950
SGTC_2654 protoveratrine a 100 µM -1.6852114857725 0.0320556088638662 no 3244 0.0459738879206589 4589 5702278 A heart drug and vasodilator.
SGTC_1099 5-nonyloxytryptamine 2.85 µM -1.68588216003091 0.0320026595262798 no 3245 0.0459092493683734 4601 23581825 A 5-HT1D beta serotonin receptor agonist.
SGTC_1468 k284-1086 134 µM -1.6898164763698 0.0316935002312663 no 3246 0.0455315353266464 4590 15996457
SGTC_1737 st035557 69.7 µM -1.69238146063514 0.0314932753401063 no 3247 0.0452866324428705 4435 5716916
SGTC_2662 daunorubicin 22.37 µM -1.70519083293805 0.030508954117095 no 3248 0.0440794195750758 4475 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_3356 9151811 4.48 µM -1.7129919151654 0.0299220736657335 no 3249 0.0433570134899433 4623 1859254 YPR165W RHO1
SGTC_1164 k060-0068 93.7 µM -1.72263270023016 0.0292097579085181 no 3250 0.0424774838344367 4601 5963676
SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM -1.72396560389844 0.0291123928847596 no 3251 0.0423570263722675 4599 23847180
SGTC_1750 st081859 2.357 µM -1.72962280744882 0.0287021454476048 no 3252 0.0418488442092598 4504 5291695
SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM -1.73117695701769 0.0285902875757836 no 3253 0.0417101039474177 4576 16623 A steroid.
SGTC_2269 7935389 174.42 µM -1.73423620410543 0.0283711615172879 no 3254 0.0414380908233581 4616 97605
SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM -1.74750130272635 0.0274371218540634 no 3255 0.0402752095653251 4576 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1
SGTC_1296 1068-0102 11.9 µM -1.75159101707549 0.0271543757524917 no 3256 0.0399220791541179 4610 767053
SGTC_1275 0867-0008 21.1 µM -1.75226495362101 0.0271080166694341 no 3257 0.0398641296719787 4593 3422836
SGTC_3293 9120939 62.045 µM -1.75634893692148 0.0268284962442834 no 3258 0.0395144230528971 4595 934087
SGTC_2574 2',4'-dihydroxychalcone 14.64 µM -1.75679569723929 0.0267980651426985 no 3259 0.0394763193837484 4593 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_1483 3453-0561 55.9 µM -1.75908106325803 0.0266428478045151 no 3260 0.039281870422016 4643 4546991
SGTC_559 1550-0661 158 µM -1.768913936199 0.0259835604751483 no 3261 0.0384541190638144 4637 5830875
SGTC_3355 9151058 44.0485 µM -1.77149083129595 0.0258130561639404 no 3262 0.0382395580124084 4628 17015728
SGTC_2789 5281112 71.43 µM -1.77207455807473 0.0257745633101903 no 3263 0.0381910907985048 4620 765948
SGTC_66 0109-0187 42.4 µM -1.77651723678181 0.025483169922404 no 3264 0.0378238517282765 4461 759417
SGTC_1278 0874-0585 172 µM -1.77918653499731 0.0253094222774062 no 3265 0.037604592587738 4647 766306
SGTC_540 1187-0821 17.3 µM -1.78143097525881 0.025164098240007 no 3266 0.0374210358655013 4553 847520
SGTC_584 0986-0246 15.4 µM -1.78673106584262 0.0248236991573025 no 3267 0.036990482762333 4675 53315 YDR232W HEM1
SGTC_3011 9081274 71.4286 µM -1.79535406235782 0.0242781423108418 no 3268 0.0362986532881835 4634 6625322
SGTC_1237 0330-0133 46.1 µM -1.80073568479874 0.023942789373564 no 3269 0.0358722751271954 4585 X1237 YHR072W ERG7
SGTC_671 0560-0003 407 µM -1.80486827878672 0.0236879191193649 no 3270 0.0355476483488164 4599 3238678
SGTC_368 fentichlor 4.58 µM -1.80569933307163 0.0236369418379129 no 3271 0.035482658451016 4618 7329 A pesticide.
SGTC_2473 5854593 8.94 µM -1.81102865466288 0.0233122268832233 no 3272 0.035068208088787 4618 2872951
SGTC_3117 9124945 49.47 µM -1.81283648807548 0.0232029320975905 no 3273 0.0349285221855513 4555 17592065
SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM -1.81309551320523 0.0231873078027054 no 3274 0.0349085455434419 4560 5355888
SGTC_1816 st051957 91.6 µM -1.81920700502414 0.0228212269605017 no 3275 0.0344399272666442 4641 674121
SGTC_2834 9001755 58.44 µM -1.8230319916098 0.0225945957837438 no 3276 0.034149272845695 4492 2989575
SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM -1.82468175335798 0.0224974343694117 no 3277 0.0340245341710131 4583 6708739 YPR165W RHO1
SGTC_2504 purpurogallin 52.29 µM -1.84501779788368 0.0213284193646485 no 3278 0.0325174748220665 4599 5281571 An antioxidant.
SGTC_610 4215-0184 155 µM -1.84762539870787 0.0211823046743203 no 3279 0.032328276406872 4662 5605015
SGTC_1812 st052057 4.327 µM -1.85100403250656 0.0209942458836737 no 3280 0.0320844864884582 4665 3645418
SGTC_1789 tunicamycin 25 nM -1.85315905050186 0.0208750345637378 no 3281 0.03192978254135 4568 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_1950 st077106 7.18 µM -1.85827900519921 0.0205941049142854 no 3282 0.0315647018320302 4563 13831864
SGTC_2053 5265679 138 µM -1.87563481046412 0.0196655119121753 no 3283 0.0303527214975052 4563 764595
SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM -1.8788945810428 0.019495128681727 no 3284 0.0301294444618812 4623 5379071
SGTC_1043 0916-0009 19.3 µM -1.87964109234508 0.019456286619726 no 3285 0.0300785044612574 4656 3101130
SGTC_871 0574-0004 149 µM -1.88215108148329 0.0193261700296718 no 3286 0.02990775270349 4608 9551173
SGTC_1136 pergolide 1.05886 µM -1.9047337156622 0.0181883995867889 no 3287 0.0284073469870792 4606 47811 A dopamine receptor agonist.
SGTC_2949 9072542 2.23 µM -1.93114621152565 0.0169305726807545 no 3288 0.0267324867959299 4626 16457352
SGTC_3007 9078383 71.4286 µM -1.93673450763552 0.0166741955554573 no 3289 0.0263889026375056 4661 6496995
SGTC_614 0462-0418 107 µM -1.96042803958136 0.0156237701524333 no 3290 0.0249728906019806 4483 5188303
SGTC_2475 5812728 15.03 µM -1.96118824926703 0.0155910292662757 no 3291 0.0249285335571179 4642 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2
SGTC_1958 st076513 41.9 µM -1.96351822388884 0.0154910479002748 no 3292 0.0247929945256889 4617 732122 YGL099W LSG1
SGTC_157 1348-1695 65.819 µM -1.96660163678134 0.0153595822464342 no 3293 0.0246145773164354 4601 5380510
SGTC_72 0744-0168 198.391 µM -1.97906237650972 0.0148380147319634 no 3294 0.0239044918964572 4586 677577
SGTC_2423 st077119 87.2 µM -1.98073747022031 0.0147690753460262 no 3295 0.0238103611868395 4609 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae).
SGTC_2730 imipramine 71.33 µM -1.98822045669087 0.0144644631115989 no 3296 0.0233936567459233 4652 3696 A tricyclic antidepressant.
SGTC_1517 deoxycholic acid methyl ester 49.2 µM -2.05972630086927 0.0118163547871228 no 3297 0.0197123568001469 4689 229346 A bile salt which induces apoptosis.
SGTC_1371 2421-0008 32.7 µM -2.06002432617767 0.0118062632243842 no 3298 0.01969810765756 4693 2827552
SGTC_1573 oleylamine 1.06 µM -2.07294802959464 0.0113757822423663 no 3299 0.0190885582290066 4684 5356789 An amine of the fatty acid oleic acid.
SGTC_3335 9143315 29.6265 µM -2.08146667725234 0.0110995468771725 no 3300 0.0186956055572525 4700 4899691
SGTC_546 peri-Naphthalide 147 µM -2.08236099333702 0.0110708879555131 no 3301 0.0186547542736115 4678 223824 A penicillin ester.
SGTC_1377 2944-0135 198 µM -2.08563291580717 0.0109665849022978 no 3302 0.0185059436809414 4688 1894137
SGTC_1336 1486-0901 104 µM -2.08823852362189 0.0108841353358208 no 3303 0.0183881619327805 4708 5006114
SGTC_333 3486-0131 40.1 µM -2.09003742095608 0.0108275278778586 no 3304 0.0183072191636605 4706 6744690
SGTC_2933 9026794 32.47 µM -2.12497692264948 0.00977778117555131 no 3305 0.0167942692818578 4672 17586027
SGTC_142 0335-0849 62.6745 µM -2.13423411028616 0.00951500575063761 no 3306 0.016411810903572 4660 3889043 YPR107C YTH1
SGTC_281 1672-3440 14.9 µM -2.13566174681917 0.00947503515866207 no 3307 0.0163534972639406 4733 6833000
SGTC_523 1934-0222 13.7 µM -2.14604255396129 0.00918878597938037 no 3308 0.0159347918916865 4698 1361595
SGTC_2063 5246145 200 µM -2.14804055942155 0.00913456843636964 no 3309 0.0158552667645593 4695 711240
SGTC_2302 7771753 200 µM -2.15687050311318 0.00889830076767894 no 3310 0.0155078779071982 4671 2203047
SGTC_380 3970-0968 6 µM -2.15691690551746 0.00889707343152555 no 3311 0.0155060697331636 4663 2891601
SGTC_2298 7976326 193.81 µM -2.16250062972974 0.00875046344387408 no 3312 0.0152898043020767 4703 2235818
SGTC_2032 5185112 25.99 µM -2.17478746300452 0.00843528992502154 no 3313 0.0148230235050701 4648 5718189
SGTC_1528 arabinosylhypoxanthine 74.6 µM -2.18262876048901 0.00823939865741873 no 3314 0.014531580010692 4739 804 An inhibitor of viral and cellular DNA polymerases.
SGTC_1192 1488-0095 21.4 µM -2.1898654699699 0.00806216845356782 no 3315 0.0142669974396657 4749 915875
SGTC_3206 9114350 49.47 µM -2.20039130707307 0.00781036882199881 no 3316 0.013889572028148 4619 17087243
SGTC_2943 9068529 45.32 µM -2.21875952944095 0.00738750326224393 no 3317 0.0132515443390638 4683 3270634
SGTC_1944 st076371 56.9 µM -2.25461613664991 0.00661979376770054 no 3318 0.0120787168465452 4719 24208455
SGTC_1366 1683-0113 21.9 µM -2.25755746997367 0.00656006611246901 no 3319 0.0119866313571543 4734 708623
SGTC_527 4476-4215 268 µM -2.28924038113624 0.00594629499700182 no 3320 0.0110326947782055 4735 4418754
SGTC_1121 fusaric acid 630.51 nM -2.30650274248397 0.00563378491002068 no 3321 0.010541278533378 4726 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler.
SGTC_3305 9127027 53.8275 µM -2.3068762891132 0.0056271867055532 no 3322 0.010530858856026 4709 41905295
SGTC_529 4076-0302 30.3 µM -2.3110614934773 0.005553728444174 no 3323 0.0104147292603385 4730 5816522
SGTC_3330 9141424 71.43 µM -2.31440129152383 0.00549572107057955 no 3324 0.0103228600572403 4739 27261020
SGTC_2187 6125751 200 µM -2.31758082993893 0.00544099803730934 no 3325 0.0102360565244652 4747 874498
SGTC_861 0443-0273 110 µM -2.33528704707186 0.00514502317262339 no 3326 0.00976421518927753 4723 6149169
SGTC_2204 7233102 200 µM -2.34758074888001 0.00494803941119098 no 3327 0.00944788843696517 4772 2172480
SGTC_2614 arthonioic acid 13.39 µM -2.39333325243015 0.00427266379932899 no 3328 0.00834803428545739 4658 6710684
SGTC_2140 5586273 200 µM -2.41755639227821 0.00394955275447521 no 3329 0.00781255632892087 4753 854421
SGTC_120 rhodamine 6G 52.259 µM -2.50821218443938 0.00292569192325543 no 3330 0.00606718885709521 4756 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase
SGTC_2966 9084041 48.03 µM -2.54838987004515 0.00255389551522665 no 3331 0.00541107253706723 4742 17741380
SGTC_307 1501-1223 22.3 µM -2.57679547144884 0.00231739807257736 no 3332 0.00498604683232951 4775 2830329
SGTC_1201 1889-3372 45.9 µM -2.57999278809734 0.00229205943882189 no 3333 0.00494011892578399 4733 5392199
SGTC_3212 9128307 49.47 µM -2.59515242302398 0.00217530180142986 no 3334 0.00472744894318526 4694 27243542
SGTC_740 k014-0057 261 µM -2.64437848319571 0.00183239380574356 no 3335 0.0040920543383325 4771 4012779
SGTC_2552 juarezic acid 87.02 µM -2.66862843090933 0.00168222891326446 no 3336 0.00380808271903452 4760 1549512
SGTC_1206 3978-0017 132 µM -2.6915970661857 0.00155042090868344 no 3337 0.00355554008562374 4761 3873677
SGTC_1231 0242-0792 125 µM -2.70087136636117 0.00149992191131334 no 3338 0.00345790402550715 4768 3707635
SGTC_1939 st074455 53.6 µM -2.73841361785498 0.00131046808039866 no 3339 0.00308681882427884 4740 1644229
SGTC_1120 ficusin 1.78878 µM -2.77544466357892 0.00114527356189404 no 3340 0.00275631397717589 4768 6199 A DNA cross-linker.
SGTC_432 NS 1619 61.3 µM -2.93423171834295 0.000631518329715472 yes 3341 0.00167187238805045 4772 4552 A K+/calcium channel activator.
SGTC_2571 chrysanthemic acid 100 µM -2.96294528557144 0.000565349343602494 yes 3342 0.0015235536346405 4774 2743 An insecticide.
SGTC_456 gingerol 170 µM -2.9708361596305 0.000548322275828516 yes 3343 0.00148495088076748 4783 442793 A herb.
SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM -3.03660604034424 0.000423787273327464 yes 3344 0.00119628967983107 4800 688788
SGTC_793 0488-0545 106 µM -3.11725621038701 0.000306927690057815 yes 3345 0.000912714266865423 4786 292548
SGTC_450 aminopyrene 156 nM -3.15066413913485 0.000267951811738406 yes 3346 0.000814498476423209 4795 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1
SGTC_1805 st050013 60.3 µM -3.15388401942391 0.000264449701857061 yes 3347 0.000805565507083583 4782 4037144
SGTC_1953 st076800 12.1 µM -3.25621982591729 0.000173012539795234 yes 3348 0.00056453149804909 4785 297591
SGTC_2522 biochanin a 4.94 µM -3.36757071787538 0.000107567549445639 yes 3349 0.000379167874110854 4795 5280373 A possible chelator.
SGTC_1931 st074438 57.1 µM -3.46505164106485 7.01349297024021e-05 yes 3350 0.000265064836160019 4799 2787313
SGTC_2600 tangeritin 87.95 µM -3.62302629217124 3.42657156343273e-05 yes 3351 0.000145588106024188 4792 68077 A bioactive flavone.
SGTC_56 0957-0365 83.25 µM -3.73128828677711 2.06287652668603e-05 yes 3352 9.52515348050763e-05 4787 6752360
SGTC_1934 st074720 32.6 µM -4.20261313326045 1.93380950901552e-06 yes 3353 1.31925652456936e-05 4798 17250992
SGTC_1589 2',5'-dimethoxyflavone 47.2 µM -4.63609598471968 1.74528204034774e-07 yes 3354 1.77525572456429e-06 4810 688667
SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM -4.8502372098097 4.90525523217664e-08 yes 3355 6.16569557936184e-07 4808 6312947
SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM -5.27832626017699 3.30139613781344e-09 yes 3356 6.51845963980203e-08 4809 689007